Term ES NES pvalue FDR FWER FATTY_ACID_METABOLISM -0.8306 -2.0259 0.0261 0.024 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION -0.742 -1.8885 0.0043 0.038 0.114 PRIMARY_BILE_ACID_BIOSYNTHESIS -0.9122 -1.9148 0.0412 0.09 TRYPTOPHAN_METABOLISM -0.6121 -1.7428 0.0221 0.07 0.393 COMPLEMENT_AND_COAGULATION_CASCADES -0.6684 -1.8126 0.0225 0.0702 0.23 PEROXISOME -0.5729 -1.7277 0.0328 0.0712 0.424 PROPANOATE_METABOLISM -0.673 -1.7462 0.0296 0.0769 0.383 RETINOL_METABOLISM -0.6183 -1.6946 0.039 0.078 0.518 LIMONENE_AND_PINENE_DEGRADATION -0.8166 -1.7043 0.0082 0.0789 0.49 BETA_ALANINE_METABOLISM -0.6503 -1.6774 0.0387 0.0824 0.575 ARGININE_AND_PROLINE_METABOLISM -0.4966 -1.6651 0.0356 0.0845 0.606 GLYCINE_SERINE_AND_THREONINE_METABOLISM -0.7419 -1.7734 0.02 0.0847 0.325 DRUG_METABOLISM_CYTOCHROME_P450 -0.6301 -1.748 0.02 0.0871 0.378 PPAR_SIGNALING_PATHWAY -0.5228 -1.6186 0.0573 0.1018 0.699 BUTANOATE_METABOLISM -0.609 -1.6242 0.0693 0.105 0.687 LINOLEIC_ACID_METABOLISM -0.529 -1.5491 0.0448 0.1473 0.82 ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM -0.477 -1.5148 0.063 0.1522 0.87 TYROSINE_METABOLISM -0.4768 -1.5183 0.0573 0.1578 0.864 METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 -0.5229 -1.4975 0.1011 0.1615 0.89 HISTIDINE_METABOLISM -0.5045 -1.5198 0.0671 0.1655 0.861 CELL_CYCLE 0.6212 1.9359 0.0022 0.2522 0.087 STEROID_HORMONE_BIOSYNTHESIS -0.4881 -1.3911 0.1613 0.2625 0.967 DNA_REPLICATION 0.7056 1.74 0.0236 0.3407 0.426 OOCYTE_MEIOSIS 0.4472 1.7184 0.0126 0.3469 0.479 PHENYLALANINE_METABOLISM -0.4686 -1.304 0.163 0.3626 0.984 BASE_EXCISION_REPAIR 0.5885 1.7479 0.0173 0.4001 0.413 PYRUVATE_METABOLISM -0.3823 -1.2159 0.2462 0.427 0.995 GLYCOLYSIS_GLUCONEOGENESIS -0.3283 -1.2222 0.2186 0.4349 0.995 P53_SIGNALING_PATHWAY 0.4682 1.6171 0.0173 0.4422 0.698 NITROGEN_METABOLISM -0.407 -1.2281 0.2026 0.4438 0.995 MISMATCH_REPAIR 0.643 1.6665 0.0539 0.4487 0.599 CITRATE_CYCLE_TCA_CYCLE -0.4014 -1.188 0.3146 0.4502 0.998 RENIN_ANGIOTENSIN_SYSTEM -0.4453 -1.2341 0.2295 0.4532 0.994 DRUG_METABOLISM_OTHER_ENZYMES -0.3915 -1.1634 0.3013 0.4703 0.998 NON_HOMOLOGOUS_END_JOINING 0.637 1.6232 0.0105 0.471 0.687 ARACHIDONIC_ACID_METABOLISM -0.3218 -1.1328 0.2756 0.4817 0.999 RNA_DEGRADATION 0.4789 1.5013 0.06 0.4822 0.897 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM -0.3949 -1.1433 0.2899 0.4826 0.999 PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0.439 1.5522 0.0187 0.4862 0.824 SPLICEOSOME 0.4675 1.5869 0.0632 0.494 0.756 SULFUR_METABOLISM 0.5379 1.526 0.0322 0.4963 0.866 NUCLEOTIDE_EXCISION_REPAIR 0.5292 1.6322 0.0425 0.4989 0.672 PENTOSE_PHOSPHATE_PATHWAY 0.4672 1.5041 0.0473 0.5008 0.893 PROXIMAL_TUBULE_BICARBONATE_RECLAMATION -0.3518 -1.1075 0.3185 0.5038 GLYCOSAMINOGLYCAN_BIOSYNTHESIS_KERATAN_SULFATE 0.567 1.5576 0.0478 0.5071 0.816 FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0.4578 1.5113 0.0574 0.5094 0.882 BLADDER_CANCER 0.4645 1.5685 0.0248 0.5105 0.79 PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0.4237 1.5325 0.0333 0.5127 0.858 PYRIMIDINE_METABOLISM 0.4662 1.7492 0.0042 0.5272 0.41 FOLATE_BIOSYNTHESIS -0.4451 -1.0785 0.3548 0.5305 PURINE_METABOLISM 0.3568 1.4655 0.0271 0.5567 0.935 SPHINGOLIPID_METABOLISM 0.4424 1.4526 0.0672 0.5654 0.943 ALPHA_LINOLENIC_ACID_METABOLISM -0.3439 -1.0273 0.4156 0.5745 UBIQUITIN_MEDIATED_PROTEOLYSIS 0.3969 1.4184 0.0994 0.5856 0.96 BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS -0.3797 -1.0308 0.4266 0.5864 VASOPRESSIN_REGULATED_WATER_REABSORPTION 0.4001 1.4091 0.1036 0.5864 0.963 LYSOSOME 0.3619 1.4247 0.1097 0.5928 0.957 AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 0.4226 1.426 0.0702 0.6156 0.954 TAURINE_AND_HYPOTAURINE_METABOLISM -0.3772 -0.9425 0.5513 0.6378 MATURITY_ONSET_DIABETES_OF_THE_YOUNG -0.3414 -0.9751 0.482 0.6381 AMINOACYL_TRNA_BIOSYNTHESIS 0.3526 0.9928 0.4611 0.6451 LONG_TERM_POTENTIATION 0.2681 0.9966 0.4606 0.6461 HUNTINGTONS_DISEASE 0.2202 1.0003 0.4298 0.6467 ASCORBATE_AND_ALDARATE_METABOLISM -0.3967 -0.9457 0.5254 0.6501 PRIMARY_IMMUNODEFICIENCY 0.4099 1.0027 0.4725 0.6501 TGF_BETA_SIGNALING_PATHWAY 0.2956 1.004 0.4649 0.6548 JAK_STAT_SIGNALING_PATHWAY 0.2781 0.9819 0.4778 0.656 INSULIN_SIGNALING_PATHWAY 0.2481 1.0067 0.4449 0.6575 DORSO_VENTRAL_AXIS_FORMATION 0.3633 1.0189 0.4644 0.658 HOMOLOGOUS_RECOMBINATION 0.6599 1.769 0.013 0.6588 0.361 INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 0.3897 1.0076 0.4664 0.663 BASAL_CELL_CARCINOMA 0.312 1.0114 0.4233 0.6642 WNT_SIGNALING_PATHWAY 0.2749 1.0189 0.4467 0.6657 GLUTATHIONE_METABOLISM 0.3119 1.1056 0.3268 0.6665 0.999 MELANOGENESIS 0.2753 1.0223 0.4177 0.6671 ADIPOCYTOKINE_SIGNALING_PATHWAY -0.2504 -0.946 0.5245 0.6677 B_CELL_RECEPTOR_SIGNALING_PATHWAY 0.3568 1.1349 0.3423 0.6711 0.998 GLIOMA 0.2732 0.9673 0.5136 0.6731 HEDGEHOG_SIGNALING_PATHWAY 0.3167 1.0225 0.4182 0.6747 RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.3168 1.1214 0.3333 0.6758 0.999 OTHER_GLYCAN_DEGRADATION 0.3935 1.1059 0.3583 0.6759 0.999 CYSTEINE_AND_METHIONINE_METABOLISM 0.338 1.1105 0.3211 0.6775 0.999 NEUROTROPHIN_SIGNALING_PATHWAY 0.299 1.0897 0.408 0.678 TYPE_II_DIABETES_MELLITUS 0.2862 0.9476 0.5182 0.6782 GNRH_SIGNALING_PATHWAY 0.2807 1.0299 0.4528 0.6784 COLORECTAL_CANCER 0.348 1.1364 0.3498 0.6784 0.998 LONG_TERM_DEPRESSION 0.2845 1.0589 0.3867 0.6789 MAPK_SIGNALING_PATHWAY 0.2839 1.1148 0.3347 0.6793 0.999 O_GLYCAN_BIOSYNTHESIS 0.3468 1.024 0.4343 0.6803 ALZHEIMERS_DISEASE 0.2277 1.0663 0.3805 0.683 ADHERENS_JUNCTION 0.3274 1.1236 0.3347 0.683 0.999 RIBOFLAVIN_METABOLISM 0.3335 0.9404 0.5205 0.6831 CELL_ADHESION_MOLECULES_CAMS 0.2867 0.9487 0.5159 0.6836 FRUCTOSE_AND_MANNOSE_METABOLISM 0.3126 1.0765 0.3584 0.6836 FOCAL_ADHESION 0.3024 1.0606 0.4196 0.6849 HEMATOPOIETIC_CELL_LINEAGE 0.3135 0.9517 0.5337 0.6853 GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR_BIOSYNTHESIS 0.371 1.0695 0.3933 0.6864 CIRCADIAN_RHYTHM_MAMMAL 0.4261 1.03 0.4528 0.6866 NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0.325 1.08 0.3712 0.6867 SELENOAMINO_ACID_METABOLISM 0.3133 1.0344 0.4086 0.6872 ACUTE_MYELOID_LEUKEMIA 0.3219 1.0899 0.3653 0.6875 GAP_JUNCTION 0.3247 1.1369 0.3347 0.6888 0.998 MELANOMA 0.2665 0.9526 0.5515 0.6906 CHEMOKINE_SIGNALING_PATHWAY 0.2996 1.0353 0.431 0.6946 GLYCEROLIPID_METABOLISM 0.2369 0.877 0.6876 0.6977 PANCREATIC_CANCER 0.3514 1.1371 0.3404 0.6998 0.998 ERBB_SIGNALING_PATHWAY 0.3224 1.1424 0.3018 0.7007 0.998 ECM_RECEPTOR_INTERACTION 0.3347 1.0364 0.4294 0.7016 GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE 0.2914 0.8781 0.6054 0.7023 T_CELL_RECEPTOR_SIGNALING_PATHWAY 0.3639 1.1465 0.3298 0.7034 0.998 ASTHMA 0.3481 0.881 0.5736 0.7042 SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 0.3907 1.3506 0.1194 0.7057 0.986 ETHER_LIPID_METABOLISM 0.2655 0.8838 0.6406 0.7066 GLYCEROPHOSPHOLIPID_METABOLISM 0.2629 1.039 0.3747 0.7067 CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0.2704 0.9163 0.5662 0.7081 TIGHT_JUNCTION 0.2327 0.9205 0.6093 0.7083 HYPERTROPHIC_CARDIOMYOPATHY_HCM 0.2692 0.912 0.5594 0.7087 FC_EPSILON_RI_SIGNALING_PATHWAY 0.331 1.1491 0.2775 0.7099 0.998 DILATED_CARDIOMYOPATHY 0.2666 0.8852 0.5784 0.7108 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS 0.3766 0.8885 0.585 0.7121 STARCH_AND_SUCROSE_METABOLISM -0.2761 -0.8812 0.5861 0.7136 ENDOMETRIAL_CANCER 0.2657 0.8909 0.6066 0.7151 PROTEASOME 0.2675 0.8591 0.578 0.7178 EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0.319 1.1509 0.2774 0.7186 0.998 TASTE_TRANSDUCTION 0.2662 0.8922 0.6178 0.7197 ONE_CARBON_POOL_BY_FOLATE -0.2946 -0.8521 0.6475 0.7201 CARDIAC_MUSCLE_CONTRACTION 0.2354 0.8531 0.6639 0.7208 ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0.262 0.8947 0.5971 0.7229 VIRAL_MYOCARDITIS 0.276 0.8982 0.5584 0.7237 ANTIGEN_PROCESSING_AND_PRESENTATION 0.2766 0.8463 0.6052 0.724 CYTOSOLIC_DNA_SENSING_PATHWAY 0.4069 1.353 0.155 0.7247 0.986 PANTOTHENATE_AND_COA_BIOSYNTHESIS -0.3031 -0.8601 0.6241 0.7263 LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0.3166 1.151 0.2934 0.7315 0.997 RNA_POLYMERASE 0.3869 1.1681 0.3116 0.7338 0.997 ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0.2434 0.8347 0.7121 0.7351 TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.3438 1.1736 0.2923 0.7358 0.996 GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE 0.4098 1.1601 0.2954 0.7384 0.997 THYROID_CANCER 0.3579 1.1786 0.275 0.7385 0.996 GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES 0.4302 1.1535 0.3072 0.7392 0.997 LYSINE_DEGRADATION -0.2676 -0.8259 0.6654 0.742 APOPTOSIS 0.3437 1.1821 0.2782 0.746 0.996 VIBRIO_CHOLERAE_INFECTION 0.3068 1.1932 0.2452 0.7514 0.996 NOTCH_SIGNALING_PATHWAY 0.3729 1.184 0.2804 0.7568 0.996 VEGF_SIGNALING_PATHWAY 0.3226 1.2033 0.2055 0.7584 0.996 GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIO_SERIES 0.4423 1.2103 0.2341 0.7585 0.995 NON_SMALL_CELL_LUNG_CANCER 0.3578 1.2169 0.2038 0.7599 0.994 NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.3848 1.1937 0.2879 0.767 0.996 OLFACTORY_TRANSDUCTION -0.1787 -0.7928 0.8264 0.7719 PROSTATE_CANCER 0.222 0.7944 0.7298 0.7748 CHRONIC_MYELOID_LEUKEMIA 0.3677 1.2251 0.2684 0.7751 0.994 GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES 0.3875 1.218 0.2112 0.7755 0.994 BASAL_TRANSCRIPTION_FACTORS 0.3982 1.2386 0.2369 0.7767 0.993 AXON_GUIDANCE 0.3462 1.2306 0.2041 0.7795 0.994 PRION_DISEASES 0.2416 0.795 0.7126 0.7804 PATHWAYS_IN_CANCER 0.3408 1.3181 0.1373 0.7804 0.991 LEISHMANIA_INFECTION 0.4568 1.3088 0.244 0.7814 0.992 AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0.1942 0.7975 0.8127 0.783 RENAL_CELL_CARCINOMA 0.3726 1.24 0.2247 0.7937 0.993 N_GLYCAN_BIOSYNTHESIS 0.344 1.2753 0.1983 0.8056 0.993 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0.3813 1.2426 0.2463 0.8073 0.993 ENDOCYTOSIS 0.3273 1.265 0.1845 0.8109 0.993 ABC_TRANSPORTERS -0.2245 -0.7448 0.8427 0.8195 REGULATION_OF_ACTIN_CYTOSKELETON 0.3258 1.2451 0.2084 0.8231 0.993 MTOR_SIGNALING_PATHWAY 0.3784 1.2528 0.1904 0.8231 0.993 SMALL_CELL_LUNG_CANCER 0.3918 1.285 0.1809 0.8267 0.993 INOSITOL_PHOSPHATE_METABOLISM 0.4129 1.2764 0.1818 0.828 0.993 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS -0.2852 -0.7239 0.7582 0.8281 TYPE_I_DIABETES_MELLITUS 0.2957 0.7422 0.7077 0.8429 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM -0.2297 -0.6758 0.7983 0.851 TERPENOID_BACKBONE_BIOSYNTHESIS -0.2935 -0.6886 0.771 0.8542 ALLOGRAFT_REJECTION 0.3145 0.7175 0.724 0.869 SYSTEMIC_LUPUS_ERYTHEMATOSUS 0.255 0.7067 0.722 0.8767 AUTOIMMUNE_THYROID_DISEASE 0.2661 0.6903 0.752 0.8838 GALACTOSE_METABOLISM 0.2139 0.6843 0.8891 0.8842 GLYCOSAMINOGLYCAN_DEGRADATION 0.2248 0.6936 0.864 0.8867 GRAFT_VERSUS_HOST_DISEASE 0.3033 0.6753 0.7475 0.888 NICOTINATE_AND_NICOTINAMIDE_METABOLISM 0.211 0.6618 0.9291 0.8976 RIBOSOME 0.2858 0.6464 0.7816 0.9085 VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0.1703 0.6352 0.9329 0.9131 STEROID_BIOSYNTHESIS -0.2562 -0.5835 0.8596 0.9203 PROTEIN_EXPORT 0.1757 0.6041 0.875 0.9223 CALCIUM_SIGNALING_PATHWAY 0.1615 0.6168 0.9858 0.9243 REGULATION_OF_AUTOPHAGY 0.1795 0.6067 0.9434 0.9269 NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 0.1391 0.5321 0.9942 0.9661 PARKINSONS_DISEASE 0.0658 0.2435 OXIDATIVE_PHOSPHORYLATION 0.0819 0.2963