{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["Supplementary Table 3"],"read":"whole","date_system":"1900"}

{"sheet":"Supplementary Table 3","index":0,"n_rows":45835,"n_cols":32,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
[null,"Level of evidence","Gene","Mapped_Gene","Pat Var","Cancer","Known Var","Predicts","Drugs_Original","Drugs","DrugClass","Evidence","Ref","Origin Database","Sample","Sample_Name","Sample_Type","Patient_Cancer","Patient_Cancer_Subtype","Patient_Variant_Type","Source_Publication_DOI","Publication_Name","Sequencing","VUS","FATHMM","Missense3D","SIFT","Score","Pipeline","CLINVAR_RESULT","DBSNP_RESULT","Exact Match"]
[0,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[10,"B3","FGFR3","FGFR3","ampl.","Cancer","ampl. (overexpr.)","sensitivity/response","R3Mab","R3Mab","fgfr inhibitor","preclinical",19381019,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[13,"B3","SMARCB1","SMARCB1","del.","Rhabdoid Cancer","del.","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",23620515,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[14,"B3","SMARCB1","SMARCB1","del.","Synovial Sarcoma","del. (underexpr.)","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",27391784,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[15,"B3","SOX10","SOX10","del.","Melanoma","loss","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24670642,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[18,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[21,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[22,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[25,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[26,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[27,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[28,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL10.csv","AITL10","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[29,"B2","BRCA1","BRCA1","del.","Prostate Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[30,"B2","BRCA1","BRCA1","del.","Her2-receptor Negative Breast Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","28578601, 28792849","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[31,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","23346317, 21862407","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[34,"B2","BRCA1","BRCA1","del.","Breast Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[35,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[36,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[37,"B2","ERCC1","ERCC1","ampl.","Bladder Carcinoma","ampl. (expr.)","sensitivity/response","Cisplatin","Cisplatin","platinum","clin. trials",26162296,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[38,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[39,"B2","PTEN","PTEN","del.","pancreatic","any variant (LoF)","response","AKT Inhibitors","AKT Inhibitors","pi3k/akt inhibitor","case report",22025163,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[40,"B2","PTEN","PTEN","del.","Pancreatic Carcinoma","loss","sensitivity/response","Akt Inhibitor MK2206","Akt Inhibitor MK2206","pi3k/akt inhibitor","case report",22025163,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[41,"B2","PTEN","PTEN","del.","endometrial","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","case report","21468130, 20944090","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[42,"B2","PTEN","PTEN","del.","prostate","any variant (LoF)","response","PI3K Beta Inhibitor","PI3K Beta Inhibitor","pi3k/akt inhibitor","case report","ASCO 2014 (abstr 2514 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[49,"B2","PTEN","PTEN","del.","Colorectal Cancer","loss","resistance","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",21163703,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[52,"B2","PTEN","PTEN","del.","Stomach Carcinoma","loss","resistance","Chemotherapy","Chemotherapy",null,"clin. trials",15900596,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[53,"B2","PTEN","PTEN","del.","Bladder Carcinoma","loss","resistance","Everolimus","Everolimus","mtor inhibitor","clin. trials",23989949,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[54,"B2","PTEN","PTEN","del.","Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",28330462,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[55,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",27091708,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[56,"B2","PTEN","PTEN","del.","Prostate Cancer","del.","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",23582881,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[59,"B2","PTEN","PTEN","del.","Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials","24387334, 21594665","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[60,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials","20813970, 21594665","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[61,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab Emtansine","Trastuzumab Emtansine","her2 inhibitor","clin. trials",26920887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[64,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","BRAF Inhibitors In BRAF Mutant Tumor","BRAF Inhibitors In BRAF Mutant Tumor","raf inhibitor","early trials","http://ascopubs.org/doi/abs/10.1200/PO.16.00054","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[65,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","PD1 Inhibitors","PD1 Inhibitors","pd1/pdl1 antibody","early trials",26645196,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[66,"B2","PTEN","PTEN","del.","prostate","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","early trials",23582881,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[67,"B2","PTEN","PTEN","del.","endometrial","any variant (LoF)","no response","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","early trials","21788564, 23238879","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[68,"B2","PTEN","PTEN","del.","cancer_unspecified","any variant (LoF)","response","Sirolimus","Sirolimus","mtor inhibitor","early trials","ASCO 2013 (abstr 2532)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[69,"B2","PTEN","PTEN","del.","colorectal","any variant (LoF)","resistance","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","late trials","21163703, 19398573","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[75,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[76,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[79,"B3","ASS1","ASS1","del.","Ovarian Cancer","loss","resistance","Platinum Compound","Platinum Compound","platinum","preclinical",19533750,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[80,"B3","BAP1","BAP1","del.","mesothelioma","any variant (LoF)","sensitivity","EZH2 Inhibitor","EZH2 Inhibitor","ezh2 inhibitor","preclinical",26437366,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[81,"B3","BAP1","BAP1","del.","melanoma","any variant (LoF)","sensitivity","HDAC Inhibitors","HDAC Inhibitors","hdac inhibitor","preclinical",22038994,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[82,"B3","BAP1","BAP1","del.","cancer_unspecified","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22683710,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[83,"B3","BAP1","BAP1","del.","renal","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22683710,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[84,"B3","BRCA1","BRCA1","del.","ovarian","del. (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22392482,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[87,"B3","CDK12","CDK12","del.","Ovarian Serous Carcinoma","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24240700,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[88,"B3","CDK12","CDK12","del.","ovarian","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical","24240700, 24554720","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[89,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[89,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","her2 inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[93,"B3","FGFR3","FGFR3","ampl.","Cancer","ampl. (overexpr.)","sensitivity/response","R3Mab","R3Mab","fgfr inhibitor","preclinical",19381019,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[96,"B3","PBRM1","PBRM1","del.","cancer_unspecified","any variant (LoF)","sensitivity","EZH2 Inhibitor In RAS Wt","EZH2 Inhibitor In RAS Wt","ezh2 inhibitor","preclinical",26552009,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[97,"B3","PTEN","PTEN","del.","breast","any variant (LoF)","sensitivity","ATM Inhibitor","ATM Inhibitor","atm inhibitor","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[98,"B3","PTEN","PTEN","del.","Breast Cancer","loss","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",25409150,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[99,"B3","PTEN","PTEN","del.","Cancer","loss","sensitivity/response","Capivasertib","Capivasertib","pi3k/akt inhibitor","preclinical",22294718,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[100,"B3","PTEN","PTEN","del.","Ovarian Cancer","loss","resistance","Cisplatin","Cisplatin","platinum","preclinical",15790433,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[101,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","mtor inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[101,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","pi3k/akt inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[106,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Lapatinib","Lapatinib","egfr inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[106,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Lapatinib","Lapatinib","her2 inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[109,"B3","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","MEK Inhibitors In BRAF Mutant Tumors","MEK Inhibitors In BRAF Mutant Tumors","mek inhibitor","preclinical",23039341,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[110,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","PI-103","PI-103","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[111,"B3","PTEN","PTEN","del.","breast","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","23085766, 22932669","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[112,"B3","PTEN","PTEN","del.","cancer_unspecified","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","21673091, 23287563, 21998291","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[113,"B3","PTEN","PTEN","del.","endometrial","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",22662154,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[114,"B3","PTEN","PTEN","del.","ovarian","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",21632463,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[115,"B3","PTEN","PTEN","del.","thyroid","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",21289267,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[116,"B3","PTEN","PTEN","del.","glioma","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","21325073, 21191045, 17804702","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[117,"B3","PTEN","PTEN","del.","lung","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",23136191,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[124,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","PI3Ka/Di","PI3Ka/Di","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[125,"B3","PTEN","PTEN","del.","Breast Cancer","loss","sensitivity/response","PI3Kbeta Inhibitor AZD8186","PI3Kbeta Inhibitor AZD8186","pi3k/akt inhibitor","preclinical",25398829,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[126,"B3","PTEN","PTEN","del.","Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[127,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[128,"B3","PTEN","PTEN","del.","Endometrial Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",23674493,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[129,"B3","PTEN","PTEN","del.","Prostate Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",11504908,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[130,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","preclinical","17936563, 19010894","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[133,"B3","PTEN","PTEN","del.","Melanoma","loss","sensitivity/response","Uprosertib","Uprosertib","pi3k/akt inhibitor","preclinical",24735930,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[134,"B3","PTEN","PTEN","del.","Melanoma","loss","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[135,"B3","SETD2","SETD2","del.","cancer_unspecified","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical","ENA 2014 (abstr 211)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[136,"B3","SMARCB1","SMARCB1","del.","Rhabdoid Cancer","del.","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",23620515,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[137,"B3","SMARCB1","SMARCB1","del.","Synovial Sarcoma","del. (underexpr.)","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",27391784,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL11.csv","AITL11","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[138,"B2","FGF19","FGF19","ampl.","Hepatocellular Carcinoma","ampl. (overexpr.)","sensitivity/response","Fisogatinib","Fisogatinib","fgfr inhibitor","clin. trials",31575541,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL12.csv","AITL12","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[139,"B2","FGF3","FGF3","ampl.","Breast Cancer","ampl.","sensitivity/response","Dovitinib","Dovitinib","multi TKI","clin. trials",23658459,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL12.csv","AITL12","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[140,"B2","FGF3","FGF3","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL12.csv","AITL12","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[141,"B2","FGF4","FGF4","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL12.csv","AITL12","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[142,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL13.csv","AITL13","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[143,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL13.csv","AITL13","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[144,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL13.csv","AITL13","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[147,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL13.csv","AITL13","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[148,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL13.csv","AITL13","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[153,"B2","ATM","ATM","del.","colorectal","any variant (LoF)","response","ATR Inhibitors","ATR Inhibitors","atr inhibitor","case report","ENA 2015 (abstract A48)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[156,"B2","ATM","ATM","del.","gastric","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","ENA 2014 (abstr 8LBA)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[159,"B2","AURKA","AURKA","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Cisplatin","Cisplatin","platinum","clin. trials",25082261,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[163,"B2","AURKA","AURKA","ampl.","Ovarian Serous Carcinoma","ampl. (overexpr.)","resistance","Platinum Compound","Platinum Compound","platinum","clin. trials",27209210,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[164,"B2","BRCA1","BRCA1","del.","Prostate Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[165,"B2","BRCA1","BRCA1","del.","Her2-receptor Negative Breast Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","28578601, 28792849","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[166,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","23346317, 21862407","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[169,"B2","BRCA1","BRCA1","del.","Breast Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[170,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[171,"B2","CHEK2","CHEK2","del.","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","AACR 2015 (abstr CT322), 26510020","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[172,"B2","CTAG2","CTAG2","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","Letetresgene Autoleucel","Letetresgene Autoleucel",null,"clin. trials",26193344,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[175,"B2","ERCC1","ERCC1","del.","Ovary Epithelial Cancer","del. (underexpr.)","sensitivity/response","Platinum Compound","Platinum Compound","platinum","clin. trials",30797591,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[178,"B2","RET","RET","ampl.","Papillary Adenocarcinoma","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",20696054,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[181,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[182,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[183,"B2","SMARCA4","SMARCA4","del.","ovarian_rhabdoid_tumor","any variant (LoF)","response","EZH2 Inhibitor","EZH2 Inhibitor","ezh2 inhibitor","case report","ESMO 2015 (abstract 302)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[186,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[187,"B3","ATM","ATM","del.","lymphoma","any variant (LoF)","sensitivity","DNA-PKc Inhibitors","DNA-PKc Inhibitors","dna-pk inhibitor","preclinical",23761041,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[190,"B3","ATM","ATM","del.","Gastric Adenocarcinoma","del. (underexpr.)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24841718,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[193,"B3","AURKA","AURKA","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","AURK Inhibitors","AURK Inhibitors","aurk inhibitor","preclinical",22302096,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[194,"B3","AURKA","AURKA","ampl.","prostate","ampl. (GoF)","sensitivity","AURK Inhibitors","AURK Inhibitors","aurk inhibitor","preclinical",22389870,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[195,"B3","AURKA","AURKA","ampl.","Cervical Adenocarcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",12559175,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[196,"B3","BIRC7","BIRC7","ampl.","Colon Cancer","ampl.","resistance","Cisplatin","Cisplatin","platinum","preclinical",23188704,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[197,"B3","BRCA1","BRCA1","del.","ovarian","del. (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22392482,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[200,"B3","CDK12","CDK12","del.","Ovarian Serous Carcinoma","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24240700,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[201,"B3","CDK12","CDK12","del.","ovarian","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical","24240700, 24554720","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[202,"B3","ERCC1","ERCC1","del.","lung","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",23934192,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[203,"B3","ERCC1","ERCC1","del.","lung","any variant (LoF)","sensitivity","Cisplatin","Cisplatin","platinum","preclinical","23275151, 23934192","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[207,"B3","FGFR3","FGFR3","ampl.","Cancer","ampl. (overexpr.)","sensitivity/response","R3Mab","R3Mab","fgfr inhibitor","preclinical",19381019,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[213,"B3","NOTCH1","NOTCH1","ampl.","Colorectal Cancer","ampl.","sensitivity/response","NOTCH1 Antibody (PF-06293622)","NOTCH1 Antibody","gamma secretase inhibitor","preclinical",26152787,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[214,"B3","PTP4A3","PTP4A3","ampl.","Colorectal Cancer","ampl. (overexpr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","preclinical",23867504,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[215,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","egfr inhibitor","preclinical",26686064,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[215,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","vegf inhibitor","preclinical",26686064,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[218,"B3","STAG2","STAG2","del.","Melanoma","del. (underexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",27500726,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[221,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[224,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[225,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[228,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[229,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[230,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[231,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL14.csv","AITL14","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[232,"B2","CCND1","CCND1","ampl.","melanoma","ampl. (GoF)","response","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","case report","ASCO 2014 (abstr 2528 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[236,"B2","CCND1","CCND1","ampl.","Mantle Cell Lymphoma","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","clin. trials",22383795,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[237,"B2","CCND1","CCND1","ampl.","Breast Cancer","ampl.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24367492,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[238,"B2","CCND1","CCND1","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",15138475,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[239,"B2","CCND1","CCND1","ampl.","lung","ampl. (GoF)","no response","Palbociclib","Palbociclib","cdk4/6 inhibitor","early trials","ASCO 2017 (abstr 9056)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[240,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[241,"B2","FANCA","FANCA","del.","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[242,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[243,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[244,"B2","RET","RET","ampl.","Papillary Adenocarcinoma","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",20696054,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[247,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[248,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[249,"B2","SMARCA4","SMARCA4","del.","ovarian_rhabdoid_tumor","any variant (LoF)","response","EZH2 Inhibitor","EZH2 Inhibitor","ezh2 inhibitor","case report","ESMO 2015 (abstract 302)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[252,"B2","SSTR5","SSTR5","ampl.","Neuroendocrine Tumor","ampl. (expr.)","sensitivity/response","Pasireotide","Pasireotide",null,"clin. trials",25376618,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[253,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[254,"B2","TUBB3","TUBB3","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Taxane Compound","Taxane Compound","alkaloid","clin. trials",23218766,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[255,"B3","AKT1","AKT1","ampl.","Melanoma","Q79K, E17K, ampl. (Overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical","24265152, 24265155","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[256,"B3","BIRC7","BIRC7","ampl.","Colon Cancer","ampl.","resistance","Cisplatin","Cisplatin","platinum","preclinical",23188704,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[257,"B3","CCND1","CCND1","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[258,"B3","CCND1","CCND1","ampl.","Breast Cancer","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",19874578,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[259,"B3","CCND1","CCND1","ampl.","Mantle Cell Lymphoma","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",16690963,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[260,"B3","CCND1","CCND1","ampl.","Ovarian Cancer","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",21278246,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[261,"B3","CCND1","CCND1","ampl.","Renal Cell Carcinoma","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",23898052,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[262,"B3","CDK12","CDK12","del.","Ovarian Serous Carcinoma","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24240700,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[263,"B3","CDK12","CDK12","del.","ovarian","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical","24240700, 24554720","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[264,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[264,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","her2 inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[268,"B3","FGFR3","FGFR3","ampl.","Cancer","ampl. (overexpr.)","sensitivity/response","R3Mab","R3Mab","fgfr inhibitor","preclinical",19381019,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[274,"B3","MYC","MYC","ampl.","myeloma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",21889194,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[275,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",23430699,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[276,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","CDK7 Inhibitors","CDK7 Inhibitors","cdk7 inhibitor","preclinical",25416950,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[280,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","FACT Inhibitor","FACT Inhibitor","fact inhibitor","preclinical",26537256,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[281,"B3","MYC","MYC","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","JQ-1","JQ-1","bet inhibitor","preclinical",21889194,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[282,"B3","MYC","MYC","ampl.","prostate","ampl. (GoF)","sensitivity","PIM Inhibitors","PIM Inhibitors","pim inhibitor","preclinical",25505253,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[283,"B3","MYC","MYC","ampl.","colorectal","ampl. (GoF)","sensitivity","Temozolomide","Temozolomide","alkylating agent","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[284,"B3","NOTCH1","NOTCH1","ampl.","Colorectal Cancer","ampl.","sensitivity/response","NOTCH1 Antibody (PF-06293622)","NOTCH1 Antibody","gamma secretase inhibitor","preclinical",26152787,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[285,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","egfr inhibitor","preclinical",26686064,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[285,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","vegf inhibitor","preclinical",26686064,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[290,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[293,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[294,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[297,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[298,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[299,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[300,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[301,"B3","TUBB3","TUBB3","ampl.","Cancer","ampl. (expr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",21576762,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL15.csv","AITL15","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[307,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[308,"B2","FOS","FOS","ampl.","Colon Adenocarcinoma","ampl. (overexpr.)","sensitivity/response","Irbesartan","Irbesartan",null,"case report",27022066,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[309,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[310,"B2","HIF1A","HIF1A","ampl.","Renal Cell Carcinoma","ampl. (expr.)","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",23881929,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[311,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[314,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[315,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[318,"B3","FOXA1","FOXA1","ampl.","colorectal","ampl. (GoF)","sensitivity","BCL2 Inhibitors","BCL2 Inhibitors","bcl2 inhibitor","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[321,"B3","PRKCH","PRKCH","ampl.","chronic_myeloid_leukemia","ampl. (GoF)","sensitivity","Trametinib (plus Imatinib In BCR-ABL)","Trametinib","mek inhibitor","preclinical",25186176,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL16.csv","AITL16","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[322,"B2","DNMT1","DNMT1","ampl.","Gastric Adenocarcinoma","ampl. (expr.)","resistance","Cisplatin","Cisplatin","platinum","clin. trials",21458988,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[323,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[328,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[329,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[330,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[333,"B3","DNMT1","DNMT1","ampl.","Ovarian Cancer","ampl. (expr.)","sensitivity/response","Decitabine","Decitabine","demethylating agent","preclinical",25968887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[334,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[334,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","her2 inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[337,"B3","MAPK1","MAPK1","ampl.","Lung Non-small Cell Carcinoma","ampl.","resistance","WZ4002","WZ4002","egfr inhibitor","preclinical",22961667,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[338,"B3","NOTCH1","NOTCH1","del.","Head And Neck Squamous Cell Carcinoma","(LoF)","sensitivity/response","Porcupine Inhibitor WNT974","Porcupine Inhibitor WNT974","wnt inhibitor","preclinical",24277854,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[339,"B3","RB1","RB1","del.","retinoblastoma","any variant (LoF)","sensitivity","HDAC Inhibitors","HDAC Inhibitors","hdac inhibitor","preclinical",18483379,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[340,"B3","RB1","RB1","del.","retinoblastoma","any variant (LoF)","sensitivity","MDM2/MDMX Inhibitors","MDM2/MDMX Inhibitors","mdm2/mdmx inhibitor","preclinical","17080083, 21515735","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[341,"B3","RB1","RB1","del.","Breast Cancer","(LoF)","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",20473330,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[342,"B3","RB1","RB1","del.","Glioblastoma","(LoF)","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",20354191,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[345,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[348,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[349,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[352,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[353,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[354,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[355,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[356,"B3","TSC2","TSC2","del.","lymphangioleiomyomatosis","any variant (LoF)","sensitivity","SRC Inhibitors","SRC Inhibitors","src inhibitor","preclinical",24691995,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL17.csv","AITL17","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[357,"B2","CTAG2","CTAG2","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","Letetresgene Autoleucel","Letetresgene Autoleucel",null,"clin. trials",26193344,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL18.csv","AITL18","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[358,"B2","FANCA","FANCA","del.","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL18.csv","AITL18","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[359,"B3","ERBB2","ERBB2","del.","breast","755-759del","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL19.csv","AITL19","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[359,"B3","ERBB2","ERBB2","del.","breast","755-759del","sensitivity","Neratinib","Neratinib","her2 inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL19.csv","AITL19","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[360,"B2","BRCA1","BRCA1","del.","Prostate Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[361,"B2","BRCA1","BRCA1","del.","Her2-receptor Negative Breast Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","28578601, 28792849","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[362,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","23346317, 21862407","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[365,"B2","BRCA1","BRCA1","del.","Breast Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[366,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[371,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[372,"B2","ERCC1","ERCC1","ampl.","Bladder Carcinoma","ampl. (expr.)","sensitivity/response","Cisplatin","Cisplatin","platinum","clin. trials",26162296,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[373,"B2","FGFR2","FGFR2","ampl.","breast","ampl. (GoF)","response","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","case report",25193991,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[374,"B2","FGFR2","FGFR2","ampl.","Breast Cancer","ampl.","sensitivity/response","Dovitinib","Dovitinib","multi TKI","clin. trials",23658459,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[375,"B2","FGFR2","FGFR2","ampl.","Stomach Carcinoma","ampl.","sensitivity/response","FGFR Inhibitor AZD4547","FGFR Inhibitor AZD4547","fgfr inhibitor","clin. trials",27179038,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[376,"B2","FGFR2","FGFR2","ampl.","gastric","ampl. (GoF)","response","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","early trials","ASCO 2015 (abstr 2508)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[377,"B2","FOS","FOS","ampl.","Colon Adenocarcinoma","ampl. (overexpr.)","sensitivity/response","Irbesartan","Irbesartan",null,"case report",27022066,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[378,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[379,"B2","HIF1A","HIF1A","ampl.","Renal Cell Carcinoma","ampl. (expr.)","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",23881929,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[382,"B2","PDCD4","PDCD4","ampl.","Lung Cancer","ampl. (expr.)","sensitivity/response","Paclitaxel","Paclitaxel","alkaloid","clin. trials",25928036,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[383,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[386,"B2","PTEN","PTEN","ampl.","Glioblastoma","ampl. (expr.)","sensitivity/response","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","egfr inhibitor","clin. trials",16282176,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[389,"B2","PTEN","PTEN","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials",16404430,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[390,"B2","RET","RET","ampl.","Papillary Adenocarcinoma","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",20696054,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[393,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[394,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[395,"B2","SMARCA4","SMARCA4","del.","ovarian_rhabdoid_tumor","any variant (LoF)","response","EZH2 Inhibitor","EZH2 Inhibitor","ezh2 inhibitor","case report","ESMO 2015 (abstract 302)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[398,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[401,"B3","AKT1","AKT1","ampl.","Melanoma","Q79K, E17K, ampl. (Overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical","24265152, 24265155","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[404,"B3","ASS1","ASS1","del.","Ovarian Cancer","loss","resistance","Platinum Compound","Platinum Compound","platinum","preclinical",19533750,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[405,"B3","BAP1","BAP1","del.","mesothelioma","any variant (LoF)","sensitivity","EZH2 Inhibitor","EZH2 Inhibitor","ezh2 inhibitor","preclinical",26437366,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[406,"B3","BAP1","BAP1","del.","melanoma","any variant (LoF)","sensitivity","HDAC Inhibitors","HDAC Inhibitors","hdac inhibitor","preclinical",22038994,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[407,"B3","BAP1","BAP1","del.","cancer_unspecified","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22683710,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[408,"B3","BAP1","BAP1","del.","renal","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22683710,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[409,"B3","BRCA1","BRCA1","del.","ovarian","del. (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22392482,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[412,"B3","CDK12","CDK12","del.","Ovarian Serous Carcinoma","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24240700,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[413,"B3","CDK12","CDK12","del.","ovarian","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical","24240700, 24554720","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[414,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[414,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","her2 inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[420,"B3","NOTCH1","NOTCH1","del.","Head And Neck Squamous Cell Carcinoma","(LoF)","sensitivity/response","Porcupine Inhibitor WNT974","Porcupine Inhibitor WNT974","wnt inhibitor","preclinical",24277854,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[421,"B3","PBRM1","PBRM1","del.","cancer_unspecified","any variant (LoF)","sensitivity","EZH2 Inhibitor In RAS Wt","EZH2 Inhibitor In RAS Wt","ezh2 inhibitor","preclinical",26552009,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[422,"B3","PRKCH","PRKCH","ampl.","chronic_myeloid_leukemia","ampl. (GoF)","sensitivity","Trametinib (plus Imatinib In BCR-ABL)","Trametinib","mek inhibitor","preclinical",25186176,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[423,"B3","PTEN","PTEN","ampl.","Glioblastoma","ampl. (expr.)","sensitivity/response","Dacomitinib","Dacomitinib","egfr inhibitor","preclinical",25939761,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[424,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","egfr inhibitor","preclinical",26686064,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[424,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","vegf inhibitor","preclinical",26686064,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[425,"B3","SETD2","SETD2","del.","cancer_unspecified","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical","ENA 2014 (abstr 211)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[426,"B3","SIRT1","SIRT1","ampl.","Pancreatic Cancer","ampl. (overexpr.)","resistance","Niacinamide","Niacinamide",null,"preclinical",24088390,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[429,"B3","STAG3","STAG3","del.","Melanoma","del. (underexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",27500726,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[432,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[435,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[436,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[439,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[440,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[441,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[442,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL1.csv","AITL1","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[443,"B2","FANCA","FANCA","del.","prostate","any variant","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL20.csv","AITL20","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[444,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL21.csv","AITL21","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[445,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL21.csv","AITL21","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[446,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL21.csv","AITL21","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[449,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL21.csv","AITL21","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[450,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL21.csv","AITL21","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[455,"B2","AKT2","AKT2","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials",22842582,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[456,"B2","DNMT1","DNMT1","ampl.","Gastric Adenocarcinoma","ampl. (expr.)","resistance","Cisplatin","Cisplatin","platinum","clin. trials",21458988,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[457,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[458,"B2","ERCC1","ERCC1","ampl.","Bladder Carcinoma","ampl. (expr.)","sensitivity/response","Cisplatin","Cisplatin","platinum","clin. trials",26162296,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[459,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[462,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[465,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[466,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[469,"B3","AKT2","AKT2","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","Allosteric AKT Inhibitors","Allosteric AKT Inhibitors","pi3k/akt inhibitor","preclinical","ENA 2014 (abstr 373)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[470,"B3","CBLC","CBLC","ampl.","Cancer","ampl. (expr.)","resistance","Olaparib","Olaparib","parp inhibitor","preclinical",25883215,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[471,"B3","CCNE1","CCNE1","ampl.","Ovarian Cancer","ampl. (overexpr.)","sensitivity/response","CDK Inhibitor SNS-032","CDK Inhibitor SNS-032","multi CDK inhibitor","preclinical",26204491,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[472,"B3","CCNE1","CCNE1","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK2 Inhibitors","CDK2 Inhibitors","cdk2/4 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[475,"B3","CCNE1","CCNE1","ampl.","Estrogen-receptor Positive Breast Cancer","ampl.","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",27020857,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[476,"B3","DNMT1","DNMT1","ampl.","Ovarian Cancer","ampl. (expr.)","sensitivity/response","Decitabine","Decitabine","demethylating agent","preclinical",25968887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[479,"B3","MAPK1","MAPK1","ampl.","Lung Non-small Cell Carcinoma","ampl.","resistance","WZ4002","WZ4002","egfr inhibitor","preclinical",22961667,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[480,"B3","PIK3R2","PIK3R2","ampl.","Melanoma","N561D, ampl. (Overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL27.csv","AITL27","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[483,"B2","AKT2","AKT2","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials",22842582,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[484,"B2","CTAG2","CTAG2","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","Letetresgene Autoleucel","Letetresgene Autoleucel",null,"clin. trials",26193344,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[485,"B2","DNMT1","DNMT1","ampl.","Gastric Adenocarcinoma","ampl. (expr.)","resistance","Cisplatin","Cisplatin","platinum","clin. trials",21458988,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[486,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[487,"B2","ERCC1","ERCC1","ampl.","Bladder Carcinoma","ampl. (expr.)","sensitivity/response","Cisplatin","Cisplatin","platinum","clin. trials",26162296,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[488,"B2","FOXP3","FOXP3","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Epirubicin","Epirubicin","anthracyclin","clin. trials",22431701,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[489,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[490,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[493,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[494,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[495,"B2","TIMP1","TIMP1","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","clin. trials",22544540,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[496,"B3","AKT2","AKT2","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","Allosteric AKT Inhibitors","Allosteric AKT Inhibitors","pi3k/akt inhibitor","preclinical","ENA 2014 (abstr 373)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[497,"B3","CASP8","CASP8","ampl.","Ewing Sarcoma Of Bone","ampl. (overexpr.)","sensitivity/response","Conatumumab","Conatumumab","dr5 antibody","preclinical",26291055,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[498,"B3","CBLC","CBLC","ampl.","Cancer","ampl. (expr.)","resistance","Olaparib","Olaparib","parp inhibitor","preclinical",25883215,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[499,"B3","CCNE1","CCNE1","ampl.","Ovarian Cancer","ampl. (overexpr.)","sensitivity/response","CDK Inhibitor SNS-032","CDK Inhibitor SNS-032","multi CDK inhibitor","preclinical",26204491,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[500,"B3","CCNE1","CCNE1","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK2 Inhibitors","CDK2 Inhibitors","cdk2/4 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[503,"B3","CCNE1","CCNE1","ampl.","Estrogen-receptor Positive Breast Cancer","ampl.","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",27020857,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[504,"B3","CFLAR","CFLAR","ampl.","Prostate Cancer","ampl. (expr.)","resistance","Bicalutamide","Bicalutamide","anti-androgen","preclinical",22623731,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[505,"B3","DNMT1","DNMT1","ampl.","Ovarian Cancer","ampl. (expr.)","sensitivity/response","Decitabine","Decitabine","demethylating agent","preclinical",25968887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[508,"B3","MAGEH1","MAGEH1","ampl.","Bile Duct Adenocarcinoma","ampl. (expr.)","resistance","Gemcitabine","Gemcitabine","antimetabolite","preclinical",20088962,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[509,"B3","PIK3R2","PIK3R2","ampl.","Melanoma","N561D, ampl. (Overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[510,"B3","TIMP1","TIMP1","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","preclinical",23881388,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL28.csv","AITL28","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[511,"B2","AGR2","AGR2","ampl.","Breast Cancer","ampl. (expr.)","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24167368,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[512,"B2","ALK","ALK","ampl.","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y, EML4::ALK L1196M, EML4::ALK T1151INST, EML4::ALK L1152R, EML4::ALK G1269A, EML4::ALK and ampl., ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","alk inhibitor","case report","20979473, 22277784, 21791641, 22235099, 23344087, 26775591","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[512,"B2","ALK","ALK","ampl.","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y, EML4::ALK L1196M, EML4::ALK T1151INST, EML4::ALK L1152R, EML4::ALK G1269A, EML4::ALK and ampl., ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","case report","20979473, 22277784, 21791641, 22235099, 23344087, 26775591","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[513,"B2","ALK","ALK","ampl.","lung_adeno","ampl. (GoF)","response","Brigatinib","Brigatinib","alk inhibitor","case report","ASCO 2017 (abstr 9065)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[513,"B2","ALK","ALK","ampl.","lung_adeno","ampl. (GoF)","response","Brigatinib","Brigatinib","egfr inhibitor","case report","ASCO 2017 (abstr 9065)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[514,"B2","ALK","ALK","ampl.","lung_adeno","ampl. (GoF)","resistance","Crizotinib","Crizotinib","alk inhibitor","case report",22277784,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[514,"B2","ALK","ALK","ampl.","lung_adeno","ampl. (GoF)","resistance","Crizotinib","Crizotinib","met inhibitor","case report",22277784,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[521,"B2","CDK6","CDK6","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","clin. trials",27252418,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[522,"B2","EGFR","EGFR","ampl.","head_neck","ampl. (GoF)","response","EGFR Inhibitors","EGFR Inhibitors","egfr inhibitor","case report",26763254,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[525,"B2","EGFR","EGFR","ampl.","Colorectal Cancer","ampl., ampl. (expr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials","18794099, 18003960, 14993230","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[526,"B2","EGFR","EGFR","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (overexpr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",23265711,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[531,"B2","EGFR","EGFR","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.), ampl.","sensitivity/response","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","egfr inhibitor","clin. trials","22056021, 26439803, 20826716","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[537,"B2","EGFR","EGFR","ampl.","Lung Non-small Cell Carcinoma","ampl. (Overexpr.), L858R, Exon 19 del., any mut., ampl. (Expr.), (GoF)","sensitivity/response","Gefitinib","Gefitinib","egfr inhibitor","clin. trials","16707605, 18509184, 20022809, 19692680, 15329413, 20038723, 12748244, 15118073","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[540,"B2","EGFR","EGFR","ampl.","Chordoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","egfr inhibitor","clin. trials",23559153,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[540,"B2","EGFR","EGFR","ampl.","Chordoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","clin. trials",23559153,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[541,"B2","EGFR","EGFR","ampl.","Esophagus Squamous Cell Carcinoma","ampl. (overexpr.)","sensitivity/response","Nimotuzumab","Nimotuzumab","egfr inhibitor","clin. trials",26459251,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[542,"B2","EGFR","EGFR","ampl.","Colorectal Cancer","ampl. (expr.)","sensitivity/response","Panitumumab","Panitumumab","egfr inhibitor","clin. trials",17470858,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[543,"B2","EGFR","EGFR","ampl.","glioma","ampl. (GoF)","no response","EGFR TKIs","EGFR TKIs","egfr inhibitor","early trials","16282176, 16278407","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[544,"B2","EGFR","EGFR","ampl.","lung","ampl. (GoF)","no response","Erlotinib","Erlotinib","egfr inhibitor","early trials","ASCO 2015 (abstr e19028)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[545,"B2","EGFR","EGFR","ampl.","head_neck","ampl. (GoF)","no response","Gefitinib","Gefitinib","egfr inhibitor","early trials","21274259, 22261807","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[546,"B2","EGFR","EGFR","ampl.","colorectal","ampl. (GoF)","response","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","late trials","18794099, 17664472","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[547,"B2","EGFR","EGFR","ampl.","esophageal","ampl. (GoF)","response","Gefitinib","Gefitinib","egfr inhibitor","late trials",24950987,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[548,"B2","EPAS1","EPAS1","ampl.","Renal Cell Carcinoma","ampl. (overexpr.)","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",23881929,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[549,"B2","EPHB4","EPHB4","ampl.","Colorectal Cancer","ampl. (expr.)","resistance","Bevacizumab","Bevacizumab","vegf inhibitor","clin. trials",23579861,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[550,"B2","FANCA","FANCA","del.","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[551,"B2","FLCN","FLCN","del.","renal","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","case report",23995526,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[552,"B2","FLCN","FLCN","del.","thyroid","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","case report",25295501,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[553,"B2","HGF","HGF","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-ampl","Trastuzumab In HER2-ampl","her2 inhibitor","early trials",22850551,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[554,"B2","HSPA5","HSPA5","ampl.","Colorectal Cancer","ampl. (expr.)","sensitivity/response","Fluorouracil","Fluorouracil","antimetabolite","clin. trials",23456958,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[555,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25232318,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[555,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25232318,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[556,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[556,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[557,"B2","MET","MET","ampl.","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[557,"B2","MET","MET","ampl.","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[558,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[558,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[559,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[559,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[562,"B2","MET","MET","ampl.","hepatocellular_carcinoma","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","case report","ENA 2015 (abstract A55)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[563,"B2","MET","MET","ampl.","Gastric Adenocarcinoma","ampl.","sensitivity/response","Onartuzumab","Onartuzumab","met inhibitor","case report",22389872,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[568,"B2","MET","MET","ampl.","glioma","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",22162573,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[568,"B2","MET","MET","ampl.","glioma","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[575,"B2","MET","MET","ampl.","Renal Cell Carcinoma","ampl.","sensitivity/response","Cabozantinib","Cabozantinib","multi TKI","clin. trials","27279544, 27462141","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[576,"B2","MET","MET","ampl.","Stomach Carcinoma","ampl. (overexpr.)","sensitivity/response","Rilotumumab","Rilotumumab","hgf antibody","clin. trials",28958504,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[577,"B2","MET","MET","ampl.","Skin Melanoma","ampl. (overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","clin. trials","26359985, 23802768","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[578,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","resistance","EGFR TKIs (EGFR Mut Disease)","EGFR TKIs","egfr inhibitor","early trials","ASCO 2015 (abstr 8089)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[579,"B2","MET","MET","ampl.","gastric","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","ASCO GI 2015 (abstr 1)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[580,"B2","MET","MET","ampl.","renal","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","23213094, AACR 2016 (abstr CT2006)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[581,"B2","MET","MET","ampl.","colorectal","ampl. (GoF)","resistance","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","early trials",23729478,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[582,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[582,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[583,"B2","MET","MET","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-amplified","Trastuzumab In HER2-amplified","her2 inhibitor","early trials",22850551,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[584,"B2","MGMT","MGMT","del.","Glioblastoma","RS16906252, del. (Underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials","25910840, 17442989, 21331613","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[585,"B2","MGMT","MGMT","del.","High Grade Glioma","del. (underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials",21365007,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[586,"B2","MGMT","MGMT","del.","Neuroendocrine Tumor","del. (underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials",19118063,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[587,"B2","MGMT","MGMT","del.","Oligodendroglioma","del. (underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials",16541434,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[588,"B2","MGMT","MGMT","del.","glioma","any variant (LoF)","increased benefit","Temozolomide","Temozolomide","alkylating agent","late trials",15758010,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[589,"B2","PIK3CA","PIK3CA","ampl.","Epithelial Ovarian Cancer","ampl.","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","case report",25370471,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[593,"B2","PTEN","PTEN","del.","pancreatic","any variant (LoF)","response","AKT Inhibitors","AKT Inhibitors","pi3k/akt inhibitor","case report",22025163,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[594,"B2","PTEN","PTEN","del.","Pancreatic Carcinoma","loss","sensitivity/response","Akt Inhibitor MK2206","Akt Inhibitor MK2206","pi3k/akt inhibitor","case report",22025163,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[595,"B2","PTEN","PTEN","del.","endometrial","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","case report","21468130, 20944090","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[596,"B2","PTEN","PTEN","del.","prostate","any variant (LoF)","response","PI3K Beta Inhibitor","PI3K Beta Inhibitor","pi3k/akt inhibitor","case report","ASCO 2014 (abstr 2514 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[603,"B2","PTEN","PTEN","del.","Colorectal Cancer","loss","resistance","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",21163703,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[606,"B2","PTEN","PTEN","del.","Stomach Carcinoma","loss","resistance","Chemotherapy","Chemotherapy",null,"clin. trials",15900596,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[607,"B2","PTEN","PTEN","del.","Bladder Carcinoma","loss","resistance","Everolimus","Everolimus","mtor inhibitor","clin. trials",23989949,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[608,"B2","PTEN","PTEN","del.","Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",28330462,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[609,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",27091708,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[610,"B2","PTEN","PTEN","del.","Prostate Cancer","del.","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",23582881,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[613,"B2","PTEN","PTEN","del.","Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials","24387334, 21594665","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[614,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials","20813970, 21594665","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[615,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab Emtansine","Trastuzumab Emtansine","her2 inhibitor","clin. trials",26920887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[618,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","BRAF Inhibitors In BRAF Mutant Tumor","BRAF Inhibitors In BRAF Mutant Tumor","raf inhibitor","early trials","http://ascopubs.org/doi/abs/10.1200/PO.16.00054","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[619,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","PD1 Inhibitors","PD1 Inhibitors","pd1/pdl1 antibody","early trials",26645196,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[620,"B2","PTEN","PTEN","del.","prostate","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","early trials",23582881,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[621,"B2","PTEN","PTEN","del.","endometrial","any variant (LoF)","no response","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","early trials","21788564, 23238879","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[622,"B2","PTEN","PTEN","del.","cancer_unspecified","any variant (LoF)","response","Sirolimus","Sirolimus","mtor inhibitor","early trials","ASCO 2013 (abstr 2532)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[623,"B2","PTEN","PTEN","del.","colorectal","any variant (LoF)","resistance","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","late trials","21163703, 19398573","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[631,"B3","ABCB1","ABCB1","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",21883677,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[632,"B3","ALK","ALK","ampl.","Lung Non-small Cell Carcinoma","F1174L, EML4::ALK and ampl., ALK Fusion G1202R, EML4::ALK L1196M, EML4::ALK S1206Y, ALK Fusion I1171, EML4::ALK  V1180L, EML4::ALK C1156Y","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical","21030459, 22277784, 25228534, 24675041","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[632,"B3","ALK","ALK","ampl.","Lung Non-small Cell Carcinoma","F1174L, EML4::ALK and ampl., ALK Fusion G1202R, EML4::ALK L1196M, EML4::ALK S1206Y, ALK Fusion I1171, EML4::ALK  V1180L, EML4::ALK C1156Y","resistance","Crizotinib","Crizotinib","met inhibitor","preclinical","21030459, 22277784, 25228534, 24675041","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[633,"B3","ASNS","ASNS","ampl.","Ovarian Cancer","ampl.","resistance","Asparaginase","Asparaginase","asparaginase","preclinical",17088436,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[634,"B3","CASP8","CASP8","ampl.","Ewing Sarcoma Of Bone","ampl. (overexpr.)","sensitivity/response","Conatumumab","Conatumumab","dr5 antibody","preclinical",26291055,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[635,"B3","CDK6","CDK6","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK6 Inhibitors","CDK6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[636,"B3","CDK6","CDK6","ampl.","Glioblastoma Proneural Subtype","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",28903422,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[641,"B3","CDKN1B","CDKN1B","del.","cancer_unspecified","any variant (LoF)","sensitivity","CDK2/4 Inhibitors","CDK2/4 Inhibitors","cdk2/4 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[642,"B3","CFLAR","CFLAR","ampl.","Prostate Cancer","ampl. (expr.)","resistance","Bicalutamide","Bicalutamide","anti-androgen","preclinical",22623731,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[643,"B3","EGFR","EGFR","ampl.","Glioma","A289V, ampl., R108K, T263P","sensitivity/response","Lapatinib","Lapatinib","egfr inhibitor","preclinical","18334972, 20459769, 22588883","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[643,"B3","EGFR","EGFR","ampl.","Glioma","A289V, ampl., R108K, T263P","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","preclinical","18334972, 20459769, 22588883","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[646,"B3","ERBB4","ERBB4","ampl.","Breast Cancer","ampl. (expr.)","resistance","Lapatinib","Lapatinib","egfr inhibitor","preclinical",25590338,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[646,"B3","ERBB4","ERBB4","ampl.","Breast Cancer","ampl. (expr.)","resistance","Lapatinib","Lapatinib","her2 inhibitor","preclinical",25590338,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[647,"B3","ERBB4","ERBB4","ampl.","Breast Cancer","nuclear translocation, ampl. (expr.)","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","preclinical",25153719,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[648,"B3","HGF","HGF","ampl.","Glioblastoma","ampl. (expr.)","sensitivity/response","MET Tyrosine Kinase Inhibitor SGX523","MET Tyrosine Kinase Inhibitor SGX523","met inhibitor","preclinical",22203985,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[649,"B3","HSPB1","HSPB1","ampl.","Pancreatic Ductal Adenocarcinoma","ampl. (expr.)","sensitivity/response","Gemcitabine","Gemcitabine","antimetabolite","preclinical",22004109,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[650,"B3","IL6","IL6","ampl.","Rhabdomyosarcoma","ampl. (overexpr.)","resistance","Bazedoxifene","Bazedoxifene","anti-estrogen","preclinical",28672024,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[651,"B3","MET","MET","ampl.","Colorectal Cancer","ampl.","resistance","Anti-EGFR Monoclonal Antibody","Anti-EGFR Monoclonal Antibody","egfr inhibitor","preclinical",23729478,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[652,"B3","MET","MET","ampl.","colorectal","ampl. (GoF)","sensitivity","BCL2 Inhibitors","BCL2 Inhibitors","bcl2 inhibitor","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[653,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",21716144,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[653,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",21716144,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[654,"B3","MET","MET","ampl.","Uveal Melanoma","ampl. (overexpr.)","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",24140933,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[654,"B3","MET","MET","ampl.","Uveal Melanoma","ampl. (overexpr.)","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",24140933,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[657,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","resistance","Gefitinib","Gefitinib","egfr inhibitor","preclinical",17463250,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[658,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","sensitivity","MET Inhibitors","MET Inhibitors","met inhibitor","preclinical","22729845, 23327903","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[661,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","egfr inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[661,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","her2 inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[662,"B3","MYCN","MYCN","ampl.","Neuroblastoma","ampl.","sensitivity/response","FACT Complex-targeting Curaxin CBL0137","FACT Complex-targeting Curaxin CBL0137","fact inhibitor","preclinical",26537256,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[665,"B3","NOTCH1","NOTCH1","ampl.","Colorectal Cancer","ampl.","sensitivity/response","NOTCH1 Antibody (PF-06293622)","NOTCH1 Antibody","gamma secretase inhibitor","preclinical",26152787,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[666,"B3","PIK3CA","PIK3CA","ampl.","Stomach Carcinoma","ampl.","sensitivity/response","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",24608574,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[669,"B3","PIK3CA","PIK3CA","ampl.","breast","ampl. (GoF)","resistance","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",24366379,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[670,"B3","PIK3CA","PIK3CA","ampl.","Head And Neck Squamous Cell Carcinoma","ampl., H1047R","sensitivity/response","Taselisib","Taselisib","pi3k/akt inhibitor","preclinical",26589432,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[671,"B3","PIK3CA","PIK3CA","ampl.","Her2-receptor Positive Breast Cancer","E545K, ampl., H1047R, C420R, K111N, I391M","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","preclinical","18829560, 19010894, 26920887","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[672,"B3","PIK3CA","PIK3CA","ampl.","Melanoma","E545K, E545G, D350G, ampl.","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[673,"B3","PTEN","PTEN","del.","breast","any variant (LoF)","sensitivity","ATM Inhibitor","ATM Inhibitor","atm inhibitor","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[674,"B3","PTEN","PTEN","del.","Breast Cancer","loss","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",25409150,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[675,"B3","PTEN","PTEN","del.","Cancer","loss","sensitivity/response","Capivasertib","Capivasertib","pi3k/akt inhibitor","preclinical",22294718,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[676,"B3","PTEN","PTEN","del.","Ovarian Cancer","loss","resistance","Cisplatin","Cisplatin","platinum","preclinical",15790433,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[677,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","mtor inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[677,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","pi3k/akt inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[682,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Lapatinib","Lapatinib","egfr inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[682,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Lapatinib","Lapatinib","her2 inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[685,"B3","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","MEK Inhibitors In BRAF Mutant Tumors","MEK Inhibitors In BRAF Mutant Tumors","mek inhibitor","preclinical",23039341,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[686,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","PI-103","PI-103","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[687,"B3","PTEN","PTEN","del.","breast","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","23085766, 22932669","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[688,"B3","PTEN","PTEN","del.","cancer_unspecified","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","21673091, 23287563, 21998291","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[689,"B3","PTEN","PTEN","del.","endometrial","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",22662154,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[690,"B3","PTEN","PTEN","del.","ovarian","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",21632463,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[691,"B3","PTEN","PTEN","del.","thyroid","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",21289267,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[692,"B3","PTEN","PTEN","del.","glioma","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","21325073, 21191045, 17804702","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[693,"B3","PTEN","PTEN","del.","lung","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",23136191,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[700,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","PI3Ka/Di","PI3Ka/Di","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[701,"B3","PTEN","PTEN","del.","Breast Cancer","loss","sensitivity/response","PI3Kbeta Inhibitor AZD8186","PI3Kbeta Inhibitor AZD8186","pi3k/akt inhibitor","preclinical",25398829,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[702,"B3","PTEN","PTEN","del.","Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[703,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[704,"B3","PTEN","PTEN","del.","Endometrial Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",23674493,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[705,"B3","PTEN","PTEN","del.","Prostate Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",11504908,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[706,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","preclinical","17936563, 19010894","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[709,"B3","PTEN","PTEN","del.","Melanoma","loss","sensitivity/response","Uprosertib","Uprosertib","pi3k/akt inhibitor","preclinical",24735930,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[710,"B3","PTEN","PTEN","del.","Melanoma","loss","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[713,"B3","RAD23B","RAD23B","ampl.","Sarcoma","ampl. (expr.)","sensitivity/response","Vorinostat","Vorinostat","hdac inhibitor","preclinical",27499916,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[714,"B3","RASA1","RASA1","del.","Lung Non-small Cell Carcinoma","(LoF)","sensitivity/response","Trametinib","Trametinib","mek inhibitor","preclinical",29127119,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[715,"B3","RRM2","RRM2","ampl.","Pancreatic Cancer","ampl. (overexpr.)","resistance","Gemcitabine","Gemcitabine","antimetabolite","preclinical",17224927,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[716,"B3","SH2B3","SH2B3","del.","myeloproliferative_neoplasm","any variant (LoF)","sensitivity","JAK Inhibitors","JAK Inhibitors","jak inhibitor","preclinical",20404132,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL29.csv","AITL29","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[717,"B2","AGR2","AGR2","ampl.","Breast Cancer","ampl. (expr.)","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24167368,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[720,"B2","AKT2","AKT2","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials",22842582,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[727,"B2","CCND1","CCND1","ampl.","melanoma","ampl. (GoF)","response","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","case report","ASCO 2014 (abstr 2528 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[731,"B2","CCND1","CCND1","ampl.","Mantle Cell Lymphoma","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","clin. trials",22383795,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[732,"B2","CCND1","CCND1","ampl.","Breast Cancer","ampl.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24367492,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[733,"B2","CCND1","CCND1","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",15138475,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[734,"B2","CCND1","CCND1","ampl.","lung","ampl. (GoF)","no response","Palbociclib","Palbociclib","cdk4/6 inhibitor","early trials","ASCO 2017 (abstr 9056)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[735,"B2","CDK6","CDK6","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","clin. trials",27252418,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[736,"B2","DNMT1","DNMT1","ampl.","Gastric Adenocarcinoma","ampl. (expr.)","resistance","Cisplatin","Cisplatin","platinum","clin. trials",21458988,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[737,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[738,"B2","EGFR","EGFR","ampl.","head_neck","ampl. (GoF)","response","EGFR Inhibitors","EGFR Inhibitors","egfr inhibitor","case report",26763254,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[741,"B2","EGFR","EGFR","ampl.","Colorectal Cancer","ampl., ampl. (expr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials","18794099, 18003960, 14993230","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[742,"B2","EGFR","EGFR","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (overexpr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",23265711,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[747,"B2","EGFR","EGFR","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.), ampl.","sensitivity/response","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","egfr inhibitor","clin. trials","22056021, 26439803, 20826716","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[753,"B2","EGFR","EGFR","ampl.","Lung Non-small Cell Carcinoma","ampl. (Overexpr.), L858R, Exon 19 del., any mut., ampl. (Expr.), (GoF)","sensitivity/response","Gefitinib","Gefitinib","egfr inhibitor","clin. trials","16707605, 18509184, 20022809, 19692680, 15329413, 20038723, 12748244, 15118073","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[756,"B2","EGFR","EGFR","ampl.","Chordoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","egfr inhibitor","clin. trials",23559153,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[756,"B2","EGFR","EGFR","ampl.","Chordoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","clin. trials",23559153,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[757,"B2","EGFR","EGFR","ampl.","Esophagus Squamous Cell Carcinoma","ampl. (overexpr.)","sensitivity/response","Nimotuzumab","Nimotuzumab","egfr inhibitor","clin. trials",26459251,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[758,"B2","EGFR","EGFR","ampl.","Colorectal Cancer","ampl. (expr.)","sensitivity/response","Panitumumab","Panitumumab","egfr inhibitor","clin. trials",17470858,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[759,"B2","EGFR","EGFR","ampl.","glioma","ampl. (GoF)","no response","EGFR TKIs","EGFR TKIs","egfr inhibitor","early trials","16282176, 16278407","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[760,"B2","EGFR","EGFR","ampl.","lung","ampl. (GoF)","no response","Erlotinib","Erlotinib","egfr inhibitor","early trials","ASCO 2015 (abstr e19028)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[761,"B2","EGFR","EGFR","ampl.","head_neck","ampl. (GoF)","no response","Gefitinib","Gefitinib","egfr inhibitor","early trials","21274259, 22261807","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[762,"B2","EGFR","EGFR","ampl.","colorectal","ampl. (GoF)","response","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","late trials","18794099, 17664472","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[763,"B2","EGFR","EGFR","ampl.","esophageal","ampl. (GoF)","response","Gefitinib","Gefitinib","egfr inhibitor","late trials",24950987,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[764,"B2","EPHB4","EPHB4","ampl.","Colorectal Cancer","ampl. (expr.)","resistance","Bevacizumab","Bevacizumab","vegf inhibitor","clin. trials",23579861,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[765,"B2","ERCC1","ERCC1","ampl.","Bladder Carcinoma","ampl. (expr.)","sensitivity/response","Cisplatin","Cisplatin","platinum","clin. trials",26162296,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[766,"B2","FGF19","FGF19","ampl.","Hepatocellular Carcinoma","ampl. (overexpr.)","sensitivity/response","Fisogatinib","Fisogatinib","fgfr inhibitor","clin. trials",31575541,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[767,"B2","FGF3","FGF3","ampl.","Breast Cancer","ampl.","sensitivity/response","Dovitinib","Dovitinib","multi TKI","clin. trials",23658459,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[768,"B2","FGF3","FGF3","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[769,"B2","FGF4","FGF4","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[770,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[771,"B2","HGF","HGF","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-ampl","Trastuzumab In HER2-ampl","her2 inhibitor","early trials",22850551,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[772,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25232318,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[772,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25232318,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[773,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[773,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[774,"B2","MET","MET","ampl.","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[774,"B2","MET","MET","ampl.","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[775,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[775,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[776,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[776,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[779,"B2","MET","MET","ampl.","hepatocellular_carcinoma","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","case report","ENA 2015 (abstract A55)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[780,"B2","MET","MET","ampl.","Gastric Adenocarcinoma","ampl.","sensitivity/response","Onartuzumab","Onartuzumab","met inhibitor","case report",22389872,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[785,"B2","MET","MET","ampl.","glioma","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",22162573,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[785,"B2","MET","MET","ampl.","glioma","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[792,"B2","MET","MET","ampl.","Non-Small Cell Lung Cancer","ampl., D1010H, D1010N, D1010Y, Exon 14 del., Exon 14 splice any mut., Y1003C, Y1003F, Y1003N","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials","21623265, 25971939, 26729443","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[792,"B2","MET","MET","ampl.","Non-Small Cell Lung Cancer","ampl., D1010H, D1010N, D1010Y, Exon 14 del., Exon 14 splice any mut., Y1003C, Y1003F, Y1003N","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials","21623265, 25971939, 26729443","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[793,"B2","MET","MET","ampl.","Stomach Carcinoma","ampl. (overexpr.)","sensitivity/response","Rilotumumab","Rilotumumab","hgf antibody","clin. trials",28958504,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[794,"B2","MET","MET","ampl.","Skin Melanoma","ampl. (overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","clin. trials","26359985, 23802768","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[795,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","resistance","EGFR TKIs (EGFR Mut Disease)","EGFR TKIs","egfr inhibitor","early trials","ASCO 2015 (abstr 8089)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[796,"B2","MET","MET","ampl.","gastric","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","ASCO GI 2015 (abstr 1)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[797,"B2","MET","MET","ampl.","renal","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","23213094, AACR 2016 (abstr CT2006)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[798,"B2","MET","MET","ampl.","colorectal","ampl. (GoF)","resistance","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","early trials",23729478,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[799,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[799,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[800,"B2","MET","MET","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-amplified","Trastuzumab In HER2-amplified","her2 inhibitor","early trials",22850551,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[801,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[802,"B2","PGR","PGR","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",23280579,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[807,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[808,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[809,"B2","ROBO4","ROBO4","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[810,"B2","RSF1","RSF1","ampl.","Breast Cancer","ampl.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24367492,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[817,"B3","ABCB1","ABCB1","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",21883677,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[818,"B3","AKT2","AKT2","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","Allosteric AKT Inhibitors","Allosteric AKT Inhibitors","pi3k/akt inhibitor","preclinical","ENA 2014 (abstr 373)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[819,"B3","ASNS","ASNS","ampl.","Ovarian Cancer","ampl.","resistance","Asparaginase","Asparaginase","asparaginase","preclinical",17088436,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[820,"B3","CBLC","CBLC","ampl.","Cancer","ampl. (expr.)","resistance","Olaparib","Olaparib","parp inhibitor","preclinical",25883215,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[821,"B3","CCND1","CCND1","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[822,"B3","CCND1","CCND1","ampl.","Breast Cancer","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",19874578,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[823,"B3","CCND1","CCND1","ampl.","Mantle Cell Lymphoma","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",16690963,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[824,"B3","CCND1","CCND1","ampl.","Ovarian Cancer","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",21278246,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[825,"B3","CCND1","CCND1","ampl.","Renal Cell Carcinoma","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",23898052,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[826,"B3","CCNE1","CCNE1","ampl.","Ovarian Cancer","ampl. (overexpr.)","sensitivity/response","CDK Inhibitor SNS-032","CDK Inhibitor SNS-032","multi CDK inhibitor","preclinical",26204491,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[827,"B3","CCNE1","CCNE1","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK2 Inhibitors","CDK2 Inhibitors","cdk2/4 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[830,"B3","CCNE1","CCNE1","ampl.","Estrogen-receptor Positive Breast Cancer","ampl.","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",27020857,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[831,"B3","CDK6","CDK6","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK6 Inhibitors","CDK6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[832,"B3","CDK6","CDK6","ampl.","Glioblastoma Proneural Subtype","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",28903422,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[840,"B3","DNMT1","DNMT1","ampl.","Ovarian Cancer","ampl. (expr.)","sensitivity/response","Decitabine","Decitabine","demethylating agent","preclinical",25968887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[841,"B3","EGFR","EGFR","ampl.","Glioma","A289V, ampl., R108K, T263P","sensitivity/response","Lapatinib","Lapatinib","egfr inhibitor","preclinical","18334972, 20459769, 22588883","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[841,"B3","EGFR","EGFR","ampl.","Glioma","A289V, ampl., R108K, T263P","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","preclinical","18334972, 20459769, 22588883","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[846,"B3","HGF","HGF","ampl.","Glioblastoma","ampl. (expr.)","sensitivity/response","MET Tyrosine Kinase Inhibitor SGX523","MET Tyrosine Kinase Inhibitor SGX523","met inhibitor","preclinical",22203985,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[847,"B3","HSPB1","HSPB1","ampl.","Pancreatic Ductal Adenocarcinoma","ampl. (expr.)","sensitivity/response","Gemcitabine","Gemcitabine","antimetabolite","preclinical",22004109,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[848,"B3","IL6","IL6","ampl.","Rhabdomyosarcoma","ampl. (overexpr.)","resistance","Bazedoxifene","Bazedoxifene","anti-estrogen","preclinical",28672024,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[849,"B3","MET","MET","ampl.","Colorectal Cancer","ampl.","resistance","Anti-EGFR Monoclonal Antibody","Anti-EGFR Monoclonal Antibody","egfr inhibitor","preclinical",23729478,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[850,"B3","MET","MET","ampl.","colorectal","ampl. (GoF)","sensitivity","BCL2 Inhibitors","BCL2 Inhibitors","bcl2 inhibitor","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[851,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",21716144,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[851,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",21716144,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[852,"B3","MET","MET","ampl.","Uveal Melanoma","ampl. (overexpr.)","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",24140933,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[852,"B3","MET","MET","ampl.","Uveal Melanoma","ampl. (overexpr.)","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",24140933,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[855,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","resistance","Gefitinib","Gefitinib","egfr inhibitor","preclinical",17463250,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[856,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","sensitivity","MET Inhibitors","MET Inhibitors","met inhibitor","preclinical","22729845, 23327903","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[859,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","egfr inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[859,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","her2 inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[860,"B3","PAK1","PAK1","ampl.","melanoma","ampl. (GoF)","sensitivity","PAK Inhibitors","PAK Inhibitors","pak inhibitor","preclinical",23535073,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL32.csv","AITL32","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[861,"B2","BRCA1","BRCA1","del.","Prostate Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[862,"B2","BRCA1","BRCA1","del.","Her2-receptor Negative Breast Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","28578601, 28792849","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[863,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","23346317, 21862407","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[866,"B2","BRCA1","BRCA1","del.","Breast Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[867,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[868,"B2","PTEN","PTEN","del.","pancreatic","any variant (LoF)","response","AKT Inhibitors","AKT Inhibitors","pi3k/akt inhibitor","case report",22025163,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[869,"B2","PTEN","PTEN","del.","Pancreatic Carcinoma","loss","sensitivity/response","Akt Inhibitor MK2206","Akt Inhibitor MK2206","pi3k/akt inhibitor","case report",22025163,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[870,"B2","PTEN","PTEN","del.","endometrial","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","case report","21468130, 20944090","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[871,"B2","PTEN","PTEN","del.","prostate","any variant (LoF)","response","PI3K Beta Inhibitor","PI3K Beta Inhibitor","pi3k/akt inhibitor","case report","ASCO 2014 (abstr 2514 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[878,"B2","PTEN","PTEN","del.","Colorectal Cancer","loss","resistance","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",21163703,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[881,"B2","PTEN","PTEN","del.","Stomach Carcinoma","loss","resistance","Chemotherapy","Chemotherapy",null,"clin. trials",15900596,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[882,"B2","PTEN","PTEN","del.","Bladder Carcinoma","loss","resistance","Everolimus","Everolimus","mtor inhibitor","clin. trials",23989949,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[883,"B2","PTEN","PTEN","del.","Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",28330462,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[884,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",27091708,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[885,"B2","PTEN","PTEN","del.","Prostate Cancer","del.","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",23582881,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[888,"B2","PTEN","PTEN","del.","Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials","24387334, 21594665","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[889,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials","20813970, 21594665","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[890,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab Emtansine","Trastuzumab Emtansine","her2 inhibitor","clin. trials",26920887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[893,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","BRAF Inhibitors In BRAF Mutant Tumor","BRAF Inhibitors In BRAF Mutant Tumor","raf inhibitor","early trials","http://ascopubs.org/doi/abs/10.1200/PO.16.00054","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[894,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","PD1 Inhibitors","PD1 Inhibitors","pd1/pdl1 antibody","early trials",26645196,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[895,"B2","PTEN","PTEN","del.","prostate","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","early trials",23582881,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[896,"B2","PTEN","PTEN","del.","endometrial","any variant (LoF)","no response","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","early trials","21788564, 23238879","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[897,"B2","PTEN","PTEN","del.","cancer_unspecified","any variant (LoF)","response","Sirolimus","Sirolimus","mtor inhibitor","early trials","ASCO 2013 (abstr 2532)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[898,"B2","PTEN","PTEN","del.","colorectal","any variant (LoF)","resistance","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","late trials","21163703, 19398573","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[902,"B3","BRCA1","BRCA1","del.","ovarian","del. (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22392482,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[905,"B3","PTEN","PTEN","del.","breast","any variant (LoF)","sensitivity","ATM Inhibitor","ATM Inhibitor","atm inhibitor","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[906,"B3","PTEN","PTEN","del.","Breast Cancer","loss","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",25409150,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[907,"B3","PTEN","PTEN","del.","Cancer","loss","sensitivity/response","Capivasertib","Capivasertib","pi3k/akt inhibitor","preclinical",22294718,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[908,"B3","PTEN","PTEN","del.","Ovarian Cancer","loss","resistance","Cisplatin","Cisplatin","platinum","preclinical",15790433,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[909,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","mtor inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[909,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","pi3k/akt inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[914,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Lapatinib","Lapatinib","egfr inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[914,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Lapatinib","Lapatinib","her2 inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[917,"B3","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","MEK Inhibitors In BRAF Mutant Tumors","MEK Inhibitors In BRAF Mutant Tumors","mek inhibitor","preclinical",23039341,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[918,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","PI-103","PI-103","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[919,"B3","PTEN","PTEN","del.","breast","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","23085766, 22932669","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[920,"B3","PTEN","PTEN","del.","cancer_unspecified","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","21673091, 23287563, 21998291","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[921,"B3","PTEN","PTEN","del.","endometrial","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",22662154,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[922,"B3","PTEN","PTEN","del.","ovarian","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",21632463,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[923,"B3","PTEN","PTEN","del.","thyroid","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",21289267,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[924,"B3","PTEN","PTEN","del.","glioma","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","21325073, 21191045, 17804702","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[925,"B3","PTEN","PTEN","del.","lung","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",23136191,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[932,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","PI3Ka/Di","PI3Ka/Di","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[933,"B3","PTEN","PTEN","del.","Breast Cancer","loss","sensitivity/response","PI3Kbeta Inhibitor AZD8186","PI3Kbeta Inhibitor AZD8186","pi3k/akt inhibitor","preclinical",25398829,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[934,"B3","PTEN","PTEN","del.","Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[935,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[936,"B3","PTEN","PTEN","del.","Endometrial Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",23674493,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[937,"B3","PTEN","PTEN","del.","Prostate Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",11504908,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[938,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","preclinical","17936563, 19010894","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[941,"B3","PTEN","PTEN","del.","Melanoma","loss","sensitivity/response","Uprosertib","Uprosertib","pi3k/akt inhibitor","preclinical",24735930,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[942,"B3","PTEN","PTEN","del.","Melanoma","loss","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL33.csv","AITL33","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[945,"B2","AKT2","AKT2","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials",22842582,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[946,"B2","ALCAM","ALCAM","ampl.","Colorectal Cancer","ampl. (expr.)","resistance","Fluorouracil","Fluorouracil","antimetabolite","clin. trials",24708484,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[953,"B2","CCND1","CCND1","ampl.","melanoma","ampl. (GoF)","response","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","case report","ASCO 2014 (abstr 2528 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[957,"B2","CCND1","CCND1","ampl.","Mantle Cell Lymphoma","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","clin. trials",22383795,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[958,"B2","CCND1","CCND1","ampl.","Breast Cancer","ampl.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24367492,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[959,"B2","CCND1","CCND1","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",15138475,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[960,"B2","CCND1","CCND1","ampl.","lung","ampl. (GoF)","no response","Palbociclib","Palbociclib","cdk4/6 inhibitor","early trials","ASCO 2017 (abstr 9056)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[961,"B2","DNMT1","DNMT1","ampl.","Gastric Adenocarcinoma","ampl. (expr.)","resistance","Cisplatin","Cisplatin","platinum","clin. trials",21458988,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[962,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[963,"B2","ERCC1","ERCC1","ampl.","Bladder Carcinoma","ampl. (expr.)","sensitivity/response","Cisplatin","Cisplatin","platinum","clin. trials",26162296,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[964,"B2","FGF19","FGF19","ampl.","Hepatocellular Carcinoma","ampl. (overexpr.)","sensitivity/response","Fisogatinib","Fisogatinib","fgfr inhibitor","clin. trials",31575541,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[965,"B2","FGF3","FGF3","ampl.","Breast Cancer","ampl.","sensitivity/response","Dovitinib","Dovitinib","multi TKI","clin. trials",23658459,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[966,"B2","FGF3","FGF3","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[967,"B2","FGF4","FGF4","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[968,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[969,"B2","MITF","MITF","ampl.","melanoma","ampl. (GoF)","resistance","BRAF Inhibitors","BRAF Inhibitors","raf inhibitor","case report",24265153,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[970,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[971,"B2","PGR","PGR","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",23280579,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[979,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[980,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[981,"B2","ROBO4","ROBO4","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[982,"B2","RSF1","RSF1","ampl.","Breast Cancer","ampl.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24367492,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[983,"B3","AKT2","AKT2","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","Allosteric AKT Inhibitors","Allosteric AKT Inhibitors","pi3k/akt inhibitor","preclinical","ENA 2014 (abstr 373)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[984,"B3","CBLC","CBLC","ampl.","Cancer","ampl. (expr.)","resistance","Olaparib","Olaparib","parp inhibitor","preclinical",25883215,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[985,"B3","CCND1","CCND1","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[986,"B3","CCND1","CCND1","ampl.","Breast Cancer","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",19874578,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[987,"B3","CCND1","CCND1","ampl.","Mantle Cell Lymphoma","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",16690963,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[988,"B3","CCND1","CCND1","ampl.","Ovarian Cancer","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",21278246,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[989,"B3","CCND1","CCND1","ampl.","Renal Cell Carcinoma","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",23898052,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[993,"B3","DNMT1","DNMT1","ampl.","Ovarian Cancer","ampl. (expr.)","sensitivity/response","Decitabine","Decitabine","demethylating agent","preclinical",25968887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[998,"B3","MYD88","MYD88","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",26596839,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[999,"B3","PAK1","PAK1","ampl.","melanoma","ampl. (GoF)","sensitivity","PAK Inhibitors","PAK Inhibitors","pak inhibitor","preclinical",23535073,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1000,"B3","PIK3R2","PIK3R2","ampl.","Melanoma","N561D, ampl. (Overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL34.csv","AITL34","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1001,"B2","CD274","CD274","ampl.","basal_cell_carcinoma","ampl. (GoF)","response","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",27942391,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1002,"B2","CD274","CD274","ampl.","Lung Non-small Cell Carcinoma","ampl. (expr.)","sensitivity/response","Atezolizumab","Atezolizumab","pd1/pdl1 antibody","clin. trials",26970723,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1014,"B2","CD274","CD274","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Nivolumab","Nivolumab","pd1/pdl1 antibody","clin. trials",22658127,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1019,"B2","CD274","CD274","ampl.","Lung Non-small Cell Carcinoma","ampl. (expr.)","sensitivity/response","Pembrolizumab","Pembrolizumab","pd1/pdl1 antibody","clin. trials","27718847, 25891174","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1020,"B2","CD274","CD274","ampl.","Merkel Cell Carcinoma","ampl. (expr.)","sensitivity/response","Pembrolizumab","Pembrolizumab","pd1/pdl1 antibody","clin. trials",27093365,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1021,"B2","CD274","CD274","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (expr.)","resistance","Radiation Therapy","Radiation Therapy",null,"clin. trials",28476872,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1022,"B2","CDKN2A","CDKN2A","ampl.","Head And Neck Squamous Cell Carcinoma","p16 ampl. (Expr.)","resistance","Afatinib","Afatinib","egfr inhibitor","clin. trials",25892145,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1022,"B2","CDKN2A","CDKN2A","ampl.","Head And Neck Squamous Cell Carcinoma","p16 ampl. (Expr.)","resistance","Afatinib","Afatinib","her2 inhibitor","clin. trials",25892145,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1022,"B2","CDKN2A","CDKN2A","ampl.","Head And Neck Squamous Cell Carcinoma","p16 ampl. (Expr.)","resistance","Afatinib","Afatinib","her4 inhibitor","clin. trials",25892145,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1023,"B2","CDKN2A","CDKN2A","ampl.","Head And Neck Squamous Cell Carcinoma","p16 ampl. (Expr.)","resistance","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",24577089,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1024,"B2","CDKN2A","CDKN2A","ampl.","Oropharynx Cancer","p16 ampl. (Expr.)","resistance","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",26712222,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1025,"B2","CDKN2A","CDKN2A","ampl.","Head And Neck Squamous Cell Carcinoma","p16 ampl. (Expr.)","resistance","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","egfr inhibitor","clin. trials",24577117,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1026,"B2","CDKN2A","CDKN2A","ampl.","Head And Neck Squamous Cell Carcinoma","p16 ampl. (Expr.)","resistance","Panitumumab","Panitumumab","egfr inhibitor","clin. trials",23746666,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1027,"B2","CDKN2A","CDKN2A","ampl.","Head And Neck Squamous Cell Carcinoma","p16 ampl. (Expr.)","sensitivity/response","Panitumumab","Panitumumab","egfr inhibitor","clin. trials",23746666,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1032,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1033,"B2","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","sensitivity/response","FGFR Inhibitor AZD4547","FGFR Inhibitor AZD4547","fgfr inhibitor","case report",27179038,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1034,"B2","FGFR1","FGFR1","ampl.","lung_squamous","ampl. (GoF)","response","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","case report",27870574,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1035,"B2","FGFR1","FGFR1","ampl.","endometrial","ampl. (GoF)","sensitivity","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","case report","ASCO 2017 (abstr 2500)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1036,"B2","FGFR1","FGFR1","ampl.","Bladder Carcinoma","ampl.","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","case report",27870574,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1037,"B2","FGFR1","FGFR1","ampl.","Adenosquamous Lung Carcinoma","ampl.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","case report",24302556,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1038,"B2","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","case report",29223982,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1040,"B2","FGFR1","FGFR1","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Dovitinib","Dovitinib","multi TKI","clin. trials",27315356,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1041,"B2","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","resistance","Infigratinib","Infigratinib","fgfr inhibitor","clin. trials",27870574,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1042,"B2","FGFR1","FGFR1","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","clin. trials",27870574,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1043,"B2","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","sensitivity/response","Lucitanib","Lucitanib","fgfr inhibitor","clin. trials",25193991,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1043,"B2","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","sensitivity/response","Lucitanib","Lucitanib","vegf inhibitor","clin. trials",25193991,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1044,"B2","FGFR1","FGFR1","ampl.","breast","ampl. (GoF)","response","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","early trials",25193991,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1045,"B2","FGFR2","FGFR2","ampl.","breast","ampl. (GoF)","response","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","case report",25193991,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1046,"B2","FGFR2","FGFR2","ampl.","Breast Cancer","ampl.","sensitivity/response","Dovitinib","Dovitinib","multi TKI","clin. trials",23658459,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1047,"B2","FGFR2","FGFR2","ampl.","Stomach Carcinoma","ampl.","sensitivity/response","FGFR Inhibitor AZD4547","FGFR Inhibitor AZD4547","fgfr inhibitor","clin. trials",27179038,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1048,"B2","FGFR2","FGFR2","ampl.","gastric","ampl. (GoF)","response","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","early trials","ASCO 2015 (abstr 2508)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1049,"B2","FOXP3","FOXP3","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Epirubicin","Epirubicin","anthracyclin","clin. trials",22431701,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1050,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1051,"B2","NRG1","NRG1","ampl.","Lung Non-small Cell Carcinoma","ampl. (expr.)","sensitivity/response","Patritumab","Patritumab","her3 inhibitor","clin. trials",26137564,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1052,"B2","PDCD4","PDCD4","ampl.","Lung Cancer","ampl. (expr.)","sensitivity/response","Paclitaxel","Paclitaxel","alkaloid","clin. trials",25928036,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1055,"B2","PTEN","PTEN","ampl.","Glioblastoma","ampl. (expr.)","sensitivity/response","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","egfr inhibitor","clin. trials",16282176,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1058,"B2","PTEN","PTEN","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials",16404430,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1059,"B2","RET","RET","ampl.","Papillary Adenocarcinoma","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",20696054,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1062,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1063,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1064,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1067,"B2","TIMP1","TIMP1","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","clin. trials",22544540,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1068,"B3","CD274","CD274","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","preclinical",25079317,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1069,"B3","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","resistance","Afimoxifene","Afimoxifene","anti-estrogen","preclinical",20179196,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1074,"B3","FGFR1","FGFR1","ampl.","head_neck","ampl. (GoF)","sensitivity","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","preclinical",23418312,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1075,"B3","FGFR1","FGFR1","ampl.","Colorectal Cancer","ampl. (expr.)","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","preclinical",24135816,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1076,"B3","FGFR1","FGFR1","ampl.","Gastric Adenocarcinoma","ampl. (expr.)","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","preclinical",26637881,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1077,"B3","FGFR1","FGFR1","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (expr.)","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","preclinical",26015511,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1078,"B3","FGFR1","FGFR1","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","PD173074","PD173074","fgfr inhibitor","preclinical",21666749,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1078,"B3","FGFR1","FGFR1","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","PD173074","PD173074","vegf inhibitor","preclinical",21666749,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1079,"B3","FGFR1","FGFR1","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","PD173074","PD173074","fgfr inhibitor","preclinical",21160078,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1079,"B3","FGFR1","FGFR1","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","PD173074","PD173074","vegf inhibitor","preclinical",21160078,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1082,"B3","FGFR1","FGFR1","ampl.","Estrogen-receptor Positive Breast Cancer","ampl.","sensitivity/response","Ponatinib","Ponatinib","multi TKI","preclinical",22238366,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1083,"B3","FGFR1","FGFR1","ampl.","Ewing Sarcoma Of Bone","ampl.","sensitivity/response","Ponatinib","Ponatinib","multi TKI","preclinical",26179511,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1084,"B3","FGFR1","FGFR1","ampl.","Lung Cancer","ampl. (expr.)","sensitivity/response","Ponatinib","Ponatinib","multi TKI","preclinical",24771645,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1087,"B3","JAK2","JAK2","ampl.","breast","ampl. (GoF)","sensitivity","JAK Inhibitors","JAK Inhibitors","jak inhibitor","preclinical",27075627,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1090,"B3","LYN","LYN","ampl.","Chronic Myeloid Leukemia","ampl. (overexpr.)","resistance","Nilotinib","Nilotinib","bcr-abl inhibitor","preclinical",18191450,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1091,"B3","MAGEH1","MAGEH1","ampl.","Bile Duct Adenocarcinoma","ampl. (expr.)","resistance","Gemcitabine","Gemcitabine","antimetabolite","preclinical",20088962,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1092,"B3","MYC","MYC","ampl.","myeloma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",21889194,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1093,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",23430699,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1094,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","CDK7 Inhibitors","CDK7 Inhibitors","cdk7 inhibitor","preclinical",25416950,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1098,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","FACT Inhibitor","FACT Inhibitor","fact inhibitor","preclinical",26537256,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1099,"B3","MYC","MYC","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","JQ-1","JQ-1","bet inhibitor","preclinical",21889194,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1100,"B3","MYC","MYC","ampl.","prostate","ampl. (GoF)","sensitivity","PIM Inhibitors","PIM Inhibitors","pim inhibitor","preclinical",25505253,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1101,"B3","MYC","MYC","ampl.","colorectal","ampl. (GoF)","sensitivity","Temozolomide","Temozolomide","alkylating agent","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1102,"B3","NRG1","NRG1","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Anti-ErbB3 Monoclonal Antibody AV-203","Anti-ErbB3 Monoclonal Antibody AV-203","her3 inhibitor","preclinical",25542901,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1103,"B3","NRG1","NRG1","ampl.","Colorectal Cancer","ampl. (expr.)","resistance","Cetuximab","Cetuximab","egfr inhibitor","preclinical",21900593,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1104,"B3","NRG1","NRG1","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","egfr inhibitor","preclinical",21840482,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1104,"B3","NRG1","NRG1","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","preclinical",21840482,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1109,"B3","NRG1","NRG1","ampl.","Ovarian Cancer","ampl. (expr.)","sensitivity/response","Seribantumab","Seribantumab","her3 inhibitor","preclinical",20227043,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1110,"B3","PBK","PBK","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Gefitinib","Gefitinib","egfr inhibitor","preclinical",26745678,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1111,"B3","PTEN","PTEN","ampl.","Glioblastoma","ampl. (expr.)","sensitivity/response","Dacomitinib","Dacomitinib","egfr inhibitor","preclinical",25939761,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1112,"B3","PTP4A3","PTP4A3","ampl.","Colorectal Cancer","ampl. (overexpr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","preclinical",23867504,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1113,"B3","RAD23B","RAD23B","ampl.","Sarcoma","ampl. (expr.)","sensitivity/response","Vorinostat","Vorinostat","hdac inhibitor","preclinical",27499916,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1114,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","egfr inhibitor","preclinical",26686064,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1114,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","vegf inhibitor","preclinical",26686064,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1115,"B3","SIRT1","SIRT1","ampl.","Pancreatic Cancer","ampl. (overexpr.)","resistance","Niacinamide","Niacinamide",null,"preclinical",24088390,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1116,"B3","SMARCB1","SMARCB1","del.","Rhabdoid Cancer","del.","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",23620515,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1117,"B3","SMARCB1","SMARCB1","del.","Synovial Sarcoma","del. (underexpr.)","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",27391784,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1120,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1123,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1124,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1127,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1128,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1129,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1130,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1131,"B3","SYK","SYK","ampl.","Ovarian Cancer","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",26096845,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1132,"B3","SYK","SYK","ampl.","mantle_cell_lymphoma, chronic_lymphocytic_leukemia","ampl. (GoF)","sensitivity","SYK Inhibitors","SYK Inhibitors","syk inhibitor","preclinical","16409295, 19549911","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1133,"B3","TIMP1","TIMP1","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","preclinical",23881388,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1134,"B3","TSC2","TSC2","del.","lymphangioleiomyomatosis","any variant (LoF)","sensitivity","SRC Inhibitors","SRC Inhibitors","src inhibitor","preclinical",24691995,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL3.csv","AITL3","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1140,"B2","BRCA1","BRCA1","del.","Prostate Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1141,"B2","BRCA1","BRCA1","del.","Her2-receptor Negative Breast Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","28578601, 28792849","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1142,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","23346317, 21862407","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1145,"B2","BRCA1","BRCA1","del.","Breast Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1146,"B2","BRCA1","BRCA1","del.","Ovarian Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1147,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1155,"B3","ASS1","ASS1","del.","Ovarian Cancer","loss","resistance","Platinum Compound","Platinum Compound","platinum","preclinical",19533750,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1156,"B3","BAP1","BAP1","del.","mesothelioma","any variant (LoF)","sensitivity","EZH2 Inhibitor","EZH2 Inhibitor","ezh2 inhibitor","preclinical",26437366,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1157,"B3","BAP1","BAP1","del.","melanoma","any variant (LoF)","sensitivity","HDAC Inhibitors","HDAC Inhibitors","hdac inhibitor","preclinical",22038994,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1158,"B3","BAP1","BAP1","del.","cancer_unspecified","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22683710,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1159,"B3","BAP1","BAP1","del.","renal","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22683710,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1160,"B3","BRCA1","BRCA1","del.","ovarian","del. (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22392482,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1163,"B3","CCND3","CCND3","del.","T-cell Lymphoblastic Leukemia/lymphoma","loss","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",23079656,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1164,"B3","CDK12","CDK12","del.","Ovarian Serous Carcinoma","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24240700,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1165,"B3","CDK12","CDK12","del.","ovarian","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical","24240700, 24554720","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1166,"B3","PBRM1","PBRM1","del.","cancer_unspecified","any variant (LoF)","sensitivity","EZH2 Inhibitor In RAS Wt","EZH2 Inhibitor In RAS Wt","ezh2 inhibitor","preclinical",26552009,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1167,"B3","SMARCB1","SMARCB1","del.","Rhabdoid Cancer","del.","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",23620515,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1168,"B3","SMARCB1","SMARCB1","del.","Synovial Sarcoma","del. (underexpr.)","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",27391784,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1171,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1174,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1175,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1178,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1179,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1180,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1181,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL4.csv","AITL4","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1185,"B1","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., L858R","sensitivity/response","Afatinib","Afatinib","egfr inhibitor","approved",23982599,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1185,"B1","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., L858R","sensitivity/response","Afatinib","Afatinib","her2 inhibitor","approved",23982599,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1185,"B1","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., L858R","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","approved",23982599,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1186,"B1","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","L858R, Exon 19 del.","sensitivity/response","Erlotinib","Erlotinib","egfr inhibitor","approved",24868098,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1187,"B2","CCND1","CCND1","ampl.","melanoma","ampl. (GoF)","response","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","case report","ASCO 2014 (abstr 2528 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1191,"B2","CCND1","CCND1","ampl.","Mantle Cell Lymphoma","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","clin. trials",22383795,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1192,"B2","CCND1","CCND1","ampl.","Breast Cancer","ampl.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24367492,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1193,"B2","CCND1","CCND1","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",15138475,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1194,"B2","CCND1","CCND1","ampl.","lung","ampl. (GoF)","no response","Palbociclib","Palbociclib","cdk4/6 inhibitor","early trials","ASCO 2017 (abstr 9056)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1195,"B2","CDKN1A","CDKN1A","ampl.","Colorectal Cancer","ampl. (expr.)","resistance","Fluorouracil","Fluorouracil","antimetabolite","clin. trials",24708484,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1196,"B2","EGFR","EGFR","del.","Lung Adenocarcinoma","S768I, K757R, E746G, V769-D770insASV, L747-S752delinsQ, Exon 19 del., P772-V774insPHV, EGFR::RAD51","sensitivity/response","Erlotinib","Erlotinib","egfr inhibitor","case report","25521405, 26773740, 15329413, 27566387, 24353160, 29290255","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1197,"B2","EGFR","EGFR","del.","Lung Adenocarcinoma","L858R, Exon 19 del.","sensitivity/response","Afatinib","Afatinib","egfr inhibitor","clin. trials","23816960, 22452895, 24439929, 25589191","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1197,"B2","EGFR","EGFR","del.","Lung Adenocarcinoma","L858R, Exon 19 del.","sensitivity/response","Afatinib","Afatinib","her2 inhibitor","clin. trials","23816960, 22452895, 24439929, 25589191","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1197,"B2","EGFR","EGFR","del.","Lung Adenocarcinoma","L858R, Exon 19 del.","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","clin. trials","23816960, 22452895, 24439929, 25589191","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1200,"B2","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., L858R, any mut.","sensitivity/response","Erlotinib","Erlotinib","egfr inhibitor","clin. trials","22285168, 15329413, 21783417","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1201,"B2","EGFR","EGFR","del.","Lung Adenocarcinoma","Exon 19 del., L858R","sensitivity/response","Gefitinib","Gefitinib","egfr inhibitor","clin. trials","22370314, 27022112","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1202,"B2","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","ampl. (Overexpr.), L858R, Exon 19 del., any mut., ampl. (Expr.), (GoF)","sensitivity/response","Gefitinib","Gefitinib","egfr inhibitor","clin. trials","16707605, 18509184, 20022809, 19692680, 15329413, 20038723, 12748244, 15118073","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1205,"B2","EGFR","EGFR","del.","glioma","exon 2-7 p.30-336 (GoF)","no response","EGFR TKIs","EGFR TKIs","egfr inhibitor","early trials",19204207,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1206,"B2","EGFR","EGFR","del.","lung","exon 19 p.729-761 (GoF)","response","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","early trials","ESMO 2012 (abstr 4380)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1209,"B2","EGFR","EGFR","del.","lung","exon 19 p.729-761 (GoF)","response","Afatinib","Afatinib","egfr inhibitor","late trials","22753918, 25589191","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1209,"B2","EGFR","EGFR","del.","lung","exon 19 p.729-761 (GoF)","response","Afatinib","Afatinib","her2 inhibitor","late trials","22753918, 25589191","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1209,"B2","EGFR","EGFR","del.","lung","exon 19 p.729-761 (GoF)","response","Afatinib","Afatinib","her4 inhibitor","late trials","22753918, 25589191","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1212,"B2","FGF19","FGF19","ampl.","Hepatocellular Carcinoma","ampl. (overexpr.)","sensitivity/response","Fisogatinib","Fisogatinib","fgfr inhibitor","clin. trials",31575541,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1213,"B2","FGF3","FGF3","ampl.","Breast Cancer","ampl.","sensitivity/response","Dovitinib","Dovitinib","multi TKI","clin. trials",23658459,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1214,"B2","FGF3","FGF3","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1215,"B2","FGF4","FGF4","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1221,"B2","NRG1","NRG1","ampl.","Lung Non-small Cell Carcinoma","ampl. (expr.)","sensitivity/response","Patritumab","Patritumab","her3 inhibitor","clin. trials",26137564,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1222,"B2","NT5E","NT5E","ampl.","Colorectal Cancer","ampl. (overexpr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",25520391,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1223,"B2","PGR","PGR","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",23280579,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1226,"B2","ROBO4","ROBO4","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1227,"B2","RSF1","RSF1","ampl.","Breast Cancer","ampl.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24367492,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1228,"B2","SGK1","SGK1","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","clin. trials",27451907,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1229,"B2","SLC29A1","SLC29A1","ampl.","Pancreatic Adenocarcinoma","ampl. (overexpr.)","sensitivity/response","Gemcitabine","Gemcitabine","antimetabolite","clin. trials",22705007,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1232,"B2","TYMS","TYMS","ampl.","Lung Adenocarcinoma","ampl.","resistance","Pemetrexed","Pemetrexed","antimetabolite","clin. trials",23645741,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1233,"B2","TYMS","TYMS","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Pemetrexed","Pemetrexed","antimetabolite","clin. trials","26502926, 23060591","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1234,"B2","TYMS","TYMS","ampl.","Gastric Adenocarcinoma","ampl. (overexpr.)","resistance","Raltitrexed","Raltitrexed","antimetabolite","clin. trials",22422354,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1239,"B2","VEGFA","VEGFA","ampl.","hepatocellular_carcinoma","ampl. (GoF)","response","Sorafenib","Sorafenib","multi TKI","early trials",24687604,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1240,"B3","ABCC10","ABCC10","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",18445659,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1241,"B3","ATR","ATR","del.","cancer_unspecified","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",23548269,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1242,"B3","BCL2","BCL2","ampl.","lymphoma","ampl. (GoF)","sensitivity","BCL2 Inhibitors","BCL2 Inhibitors","bcl2 inhibitor","preclinical",22649144,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1243,"B3","BRAF","BRAF","del.","cancer_unspecified","L485-P490 (GoF)","response","Pan-RAF Inhibitor","Pan-RAF Inhibitor","raf inhibitor","preclinical",26732095,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1244,"B3","BRAF","BRAF","del.","cancer_unspecified","L485-P490 (GoF)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",26732095,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1245,"B3","CCND1","CCND1","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1246,"B3","CCND1","CCND1","ampl.","Breast Cancer","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",19874578,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1247,"B3","CCND1","CCND1","ampl.","Mantle Cell Lymphoma","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",16690963,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1248,"B3","CCND1","CCND1","ampl.","Ovarian Cancer","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",21278246,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1249,"B3","CCND1","CCND1","ampl.","Renal Cell Carcinoma","ampl.","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",23898052,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1250,"B3","CCND3","CCND3","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1251,"B3","CD44","CD44","ampl.","Cancer","CD44s ampl. (Expr.)","sensitivity/response","RG7356","RG7356","anti-cd44 antibody","preclinical",25762343,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1258,"B3","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., L858R, T790M","sensitivity/response","Afatinib","Afatinib","egfr inhibitor","preclinical","25862853, 26515464, 18408761, 21732342","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1258,"B3","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., L858R, T790M","sensitivity/response","Afatinib","Afatinib","her2 inhibitor","preclinical","25862853, 26515464, 18408761, 21732342","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1258,"B3","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., L858R, T790M","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","preclinical","25862853, 26515464, 18408761, 21732342","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1259,"B3","EGFR","EGFR","del.","Epithelial Ovarian Cancer","exon 4 del.","resistance","Cisplatin","Cisplatin","platinum","preclinical",23764753,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1260,"B3","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., G719S, L858R, E746-A750del","sensitivity/response","Gefitinib","Gefitinib","egfr inhibitor","preclinical","16730237, 15118125, 24893891","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1261,"B3","EGFR","EGFR","del.","lung","exon 19 p.729-761 (GoF)","sensitivity","MEK Inhibitors (alone Or In Combination)","MEK Inhibitors","mek inhibitor","preclinical",23102728,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1264,"B3","LYN","LYN","ampl.","Chronic Myeloid Leukemia","ampl. (overexpr.)","resistance","Nilotinib","Nilotinib","bcr-abl inhibitor","preclinical",18191450,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1265,"B3","MAPK1","MAPK1","ampl.","Lung Non-small Cell Carcinoma","ampl.","resistance","WZ4002","WZ4002","egfr inhibitor","preclinical",22961667,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1266,"B3","MYC","MYC","ampl.","myeloma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",21889194,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1267,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",23430699,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1268,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","CDK7 Inhibitors","CDK7 Inhibitors","cdk7 inhibitor","preclinical",25416950,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1272,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","FACT Inhibitor","FACT Inhibitor","fact inhibitor","preclinical",26537256,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1273,"B3","MYC","MYC","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","JQ-1","JQ-1","bet inhibitor","preclinical",21889194,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1274,"B3","MYC","MYC","ampl.","prostate","ampl. (GoF)","sensitivity","PIM Inhibitors","PIM Inhibitors","pim inhibitor","preclinical",25505253,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1275,"B3","MYC","MYC","ampl.","colorectal","ampl. (GoF)","sensitivity","Temozolomide","Temozolomide","alkylating agent","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1276,"B3","NRG1","NRG1","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Anti-ErbB3 Monoclonal Antibody AV-203","Anti-ErbB3 Monoclonal Antibody AV-203","her3 inhibitor","preclinical",25542901,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1277,"B3","NRG1","NRG1","ampl.","Colorectal Cancer","ampl. (expr.)","resistance","Cetuximab","Cetuximab","egfr inhibitor","preclinical",21900593,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1278,"B3","NRG1","NRG1","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","egfr inhibitor","preclinical",21840482,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1278,"B3","NRG1","NRG1","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","preclinical",21840482,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1283,"B3","NRG1","NRG1","ampl.","Ovarian Cancer","ampl. (expr.)","sensitivity/response","Seribantumab","Seribantumab","her3 inhibitor","preclinical",20227043,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1284,"B3","PAK1","PAK1","ampl.","melanoma","ampl. (GoF)","sensitivity","PAK Inhibitors","PAK Inhibitors","pak inhibitor","preclinical",23535073,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1285,"B3","PBK","PBK","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Gefitinib","Gefitinib","egfr inhibitor","preclinical",26745678,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1286,"B3","PTP4A3","PTP4A3","ampl.","Colorectal Cancer","ampl. (overexpr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","preclinical",23867504,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1287,"B3","RRM1","RRM1","ampl.","Pancreatic Cancer","ampl. (overexpr.)","resistance","Gemcitabine","Gemcitabine","antimetabolite","preclinical",17224927,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1288,"B3","SGK1","SGK1","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",27451907,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1291,"B3","TSC2","TSC2","del.","lymphangioleiomyomatosis","any variant (LoF)","sensitivity","SRC Inhibitors","SRC Inhibitors","src inhibitor","preclinical",24691995,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL5.csv","AITL5","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1292,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL6.csv","AITL6","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1295,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL6.csv","AITL6","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1298,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL6.csv","AITL6","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1299,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL6.csv","AITL6","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1302,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL6.csv","AITL6","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1303,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL6.csv","AITL6","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1304,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL6.csv","AITL6","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1305,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL6.csv","AITL6","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1312,"B2","CDK6","CDK6","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","clin. trials",27252418,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1313,"B2","EPHB4","EPHB4","ampl.","Colorectal Cancer","ampl. (expr.)","resistance","Bevacizumab","Bevacizumab","vegf inhibitor","clin. trials",23579861,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1314,"B2","FGF19","FGF19","ampl.","Hepatocellular Carcinoma","ampl. (overexpr.)","sensitivity/response","Fisogatinib","Fisogatinib","fgfr inhibitor","clin. trials",31575541,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1315,"B2","FGF3","FGF3","ampl.","Breast Cancer","ampl.","sensitivity/response","Dovitinib","Dovitinib","multi TKI","clin. trials",23658459,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1316,"B2","FGF3","FGF3","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1317,"B2","FGF4","FGF4","ampl.","breast","ampl. (GoF)","response","Dovitinib","Dovitinib","multi TKI","early trials",23658459,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1318,"B2","HGF","HGF","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-ampl","Trastuzumab In HER2-ampl","her2 inhibitor","early trials",22850551,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1319,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25232318,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1319,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25232318,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1320,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1320,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1321,"B2","MET","MET","ampl.","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1321,"B2","MET","MET","ampl.","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1322,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1322,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1323,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1323,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1326,"B2","MET","MET","ampl.","hepatocellular_carcinoma","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","case report","ENA 2015 (abstract A55)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1327,"B2","MET","MET","ampl.","Gastric Adenocarcinoma","ampl.","sensitivity/response","Onartuzumab","Onartuzumab","met inhibitor","case report",22389872,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1332,"B2","MET","MET","ampl.","glioma","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",22162573,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1332,"B2","MET","MET","ampl.","glioma","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1339,"B2","MET","MET","ampl.","Renal Cell Carcinoma","ampl.","sensitivity/response","Cabozantinib","Cabozantinib","multi TKI","clin. trials","27279544, 27462141","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1340,"B2","MET","MET","ampl.","Stomach Carcinoma","ampl. (overexpr.)","sensitivity/response","Rilotumumab","Rilotumumab","hgf antibody","clin. trials",28958504,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1341,"B2","MET","MET","ampl.","Skin Melanoma","ampl. (overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","clin. trials","26359985, 23802768","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1342,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","resistance","EGFR TKIs (EGFR Mut Disease)","EGFR TKIs","egfr inhibitor","early trials","ASCO 2015 (abstr 8089)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1343,"B2","MET","MET","ampl.","gastric","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","ASCO GI 2015 (abstr 1)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1344,"B2","MET","MET","ampl.","renal","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","23213094, AACR 2016 (abstr CT2006)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1345,"B2","MET","MET","ampl.","colorectal","ampl. (GoF)","resistance","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","early trials",23729478,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1346,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1346,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1347,"B2","MET","MET","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-amplified","Trastuzumab In HER2-amplified","her2 inhibitor","early trials",22850551,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1348,"B2","MGMT","MGMT","del.","Glioblastoma","RS16906252, del. (Underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials","25910840, 17442989, 21331613","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1349,"B2","MGMT","MGMT","del.","High Grade Glioma","del. (underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials",21365007,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1350,"B2","MGMT","MGMT","del.","Neuroendocrine Tumor","del. (underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials",19118063,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1351,"B2","MGMT","MGMT","del.","Oligodendroglioma","del. (underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials",16541434,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1352,"B2","MGMT","MGMT","del.","glioma","any variant (LoF)","increased benefit","Temozolomide","Temozolomide","alkylating agent","late trials",15758010,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1353,"B2","PGR","PGR","ampl.","Breast Cancer","ampl. (expr.)","sensitivity/response","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",23280579,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1356,"B2","ROBO4","ROBO4","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1357,"B2","RSF1","RSF1","ampl.","Breast Cancer","ampl.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24367492,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1358,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1363,"B3","ABCB1","ABCB1","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",21883677,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1364,"B3","ASNS","ASNS","ampl.","Ovarian Cancer","ampl.","resistance","Asparaginase","Asparaginase","asparaginase","preclinical",17088436,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1365,"B3","CD44","CD44","ampl.","Cancer","CD44s ampl. (Expr.)","sensitivity/response","RG7356","RG7356","anti-cd44 antibody","preclinical",25762343,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1366,"B3","CDK6","CDK6","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK6 Inhibitors","CDK6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1367,"B3","CDK6","CDK6","ampl.","Glioblastoma Proneural Subtype","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",28903422,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1375,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1375,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","her2 inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1376,"B3","HGF","HGF","ampl.","Glioblastoma","ampl. (expr.)","sensitivity/response","MET Tyrosine Kinase Inhibitor SGX523","MET Tyrosine Kinase Inhibitor SGX523","met inhibitor","preclinical",22203985,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1377,"B3","MET","MET","ampl.","Colorectal Cancer","ampl.","resistance","Anti-EGFR Monoclonal Antibody","Anti-EGFR Monoclonal Antibody","egfr inhibitor","preclinical",23729478,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1378,"B3","MET","MET","ampl.","colorectal","ampl. (GoF)","sensitivity","BCL2 Inhibitors","BCL2 Inhibitors","bcl2 inhibitor","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1379,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",21716144,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1379,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",21716144,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1380,"B3","MET","MET","ampl.","Uveal Melanoma","ampl. (overexpr.)","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",24140933,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1380,"B3","MET","MET","ampl.","Uveal Melanoma","ampl. (overexpr.)","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",24140933,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1383,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","resistance","Gefitinib","Gefitinib","egfr inhibitor","preclinical",17463250,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1384,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","sensitivity","MET Inhibitors","MET Inhibitors","met inhibitor","preclinical","22729845, 23327903","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1387,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","egfr inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1387,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","her2 inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1388,"B3","NOTCH1","NOTCH1","del.","Head And Neck Squamous Cell Carcinoma","(LoF)","sensitivity/response","Porcupine Inhibitor WNT974","Porcupine Inhibitor WNT974","wnt inhibitor","preclinical",24277854,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1389,"B3","PAK1","PAK1","ampl.","melanoma","ampl. (GoF)","sensitivity","PAK Inhibitors","PAK Inhibitors","pak inhibitor","preclinical",23535073,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1390,"B3","RRM1","RRM1","ampl.","Pancreatic Cancer","ampl. (overexpr.)","resistance","Gemcitabine","Gemcitabine","antimetabolite","preclinical",17224927,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1393,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1396,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1397,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1400,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1401,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1402,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1403,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1404,"B3","TSC2","TSC2","del.","lymphangioleiomyomatosis","any variant (LoF)","sensitivity","SRC Inhibitors","SRC Inhibitors","src inhibitor","preclinical",24691995,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL7.csv","AITL7","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1408,"B2","ARID1A","ARID1A","del.","breast cancer","any mut. (LoF)","resistance","Trastuzumab (ANXA1 High)","Trastuzumab","her2 inhibitor","early trials",27172896,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL8.csv","AITL8","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1409,"B2","ECSCR","ECSCR","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Angiogenesis Inhibitor","Angiogenesis Inhibitor","vegf inhibitor","clin. trials",26956051,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL8.csv","AITL8","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1410,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL8.csv","AITL8","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1411,"B2","PDGFRB","PDGFRB","ampl.","Dermatofibrosarcoma Protuberans","ampl. (overexpr.)","sensitivity/response","Sunitinib","Sunitinib","multi TKI","case report",29760553,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL8.csv","AITL8","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1414,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL8.csv","AITL8","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1415,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL8.csv","AITL8","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1416,"B3","ARID1A","ARID1A","del.","Ovarian Clear Cell Carcinoma","(LoF), Q456*, P1175FS*5","sensitivity/response","Dasatinib","Dasatinib","bcr-abl inhibitor","preclinical",27364904,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL8.csv","AITL8","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1417,"B3","ARID1A","ARID1A","del.","Ovarian Clear Cell Carcinoma","(LoF)","sensitivity/response","GSK126","GSK126","ezh2 inhibitor","preclinical",25686104,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL8.csv","AITL8","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[1422,"B2","STK11","STK11","del.","lung_adeno","any variant (LoF)","resistance","PD1 Blockade (if KRAS Co-mutation)","PD1 Blockade","pd1/pdl1 antibody","early trials","ASCO 2017 (abstr 9016)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1425,"B3","SMARCA1","SMARCA1","del.","cancer_unspecified","any variant (LoF)","sensitivity","EZH2 Inhibitor In RAS Wt","EZH2 Inhibitor In RAS Wt","ezh2 inhibitor","preclinical",26552009,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1426,"B3","STAG2","STAG2","del.","Melanoma","del. (underexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",27500726,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1429,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1432,"B3","STK11","STK11","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","SB202190","SB202190","mapk inhibitor","preclinical",26391455,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1433,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","SRC Inhibitors (in Combination With PI3K/MEK Inhibitors)","SRC Inhibitors","src inhibitor","preclinical",20541700,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1436,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1437,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1438,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19165201,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1439,"B3","STK11","STK11","del.","lung_adeno","any variant (LoF)","sensitivity","Phenformin","Phenformin",null,"preclinical",23352126,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_AITL9.csv","AITL9","Patient","lymphoma","AITL","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1440,"B2","AGR2","AGR2","ampl.","Breast Cancer","ampl. (expr.)","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",24167368,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1441,"B2","AURKA","AURKA","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Cisplatin","Cisplatin","platinum","clin. trials",25082261,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1445,"B2","AURKA","AURKA","ampl.","Ovarian Serous Carcinoma","ampl. (overexpr.)","resistance","Platinum Compound","Platinum Compound","platinum","clin. trials",27209210,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1448,"B2","BIRC5","BIRC5","ampl.","Her2-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials",23204226,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1455,"B2","CDK6","CDK6","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","clin. trials",27252418,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1456,"B2","CHEK2","CHEK2","del.","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","AACR 2015 (abstr CT322), 26510020","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1457,"B2","EGFR","EGFR","ampl.","head_neck","ampl. (GoF)","response","EGFR Inhibitors","EGFR Inhibitors","egfr inhibitor","case report",26763254,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1460,"B2","EGFR","EGFR","ampl.","Colorectal Cancer","ampl., ampl. (expr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials","18794099, 18003960, 14993230","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1461,"B2","EGFR","EGFR","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (overexpr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",23265711,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1466,"B2","EGFR","EGFR","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.), ampl.","sensitivity/response","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","egfr inhibitor","clin. trials","22056021, 26439803, 20826716","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1472,"B2","EGFR","EGFR","ampl.","Lung Non-small Cell Carcinoma","ampl. (Overexpr.), L858R, Exon 19 del., any mut., ampl. (Expr.), (GoF)","sensitivity/response","Gefitinib","Gefitinib","egfr inhibitor","clin. trials","16707605, 18509184, 20022809, 19692680, 15329413, 20038723, 12748244, 15118073","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1475,"B2","EGFR","EGFR","ampl.","Chordoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","egfr inhibitor","clin. trials",23559153,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1475,"B2","EGFR","EGFR","ampl.","Chordoma","ampl. (expr.)","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","clin. trials",23559153,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1476,"B2","EGFR","EGFR","ampl.","Esophagus Squamous Cell Carcinoma","ampl. (overexpr.)","sensitivity/response","Nimotuzumab","Nimotuzumab","egfr inhibitor","clin. trials",26459251,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1477,"B2","EGFR","EGFR","ampl.","Colorectal Cancer","ampl. (expr.)","sensitivity/response","Panitumumab","Panitumumab","egfr inhibitor","clin. trials",17470858,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1478,"B2","EGFR","EGFR","ampl.","glioma","ampl. (GoF)","no response","EGFR TKIs","EGFR TKIs","egfr inhibitor","early trials","16282176, 16278407","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1479,"B2","EGFR","EGFR","ampl.","lung","ampl. (GoF)","no response","Erlotinib","Erlotinib","egfr inhibitor","early trials","ASCO 2015 (abstr e19028)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1480,"B2","EGFR","EGFR","ampl.","head_neck","ampl. (GoF)","no response","Gefitinib","Gefitinib","egfr inhibitor","early trials","21274259, 22261807","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1481,"B2","EGFR","EGFR","ampl.","colorectal","ampl. (GoF)","response","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","late trials","18794099, 17664472","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1482,"B2","EGFR","EGFR","ampl.","esophageal","ampl. (GoF)","response","Gefitinib","Gefitinib","egfr inhibitor","late trials",24950987,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1483,"B2","EPHB4","EPHB4","ampl.","Colorectal Cancer","ampl. (expr.)","resistance","Bevacizumab","Bevacizumab","vegf inhibitor","clin. trials",23579861,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1484,"B2","FLCN","FLCN","del.","renal","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","case report",23995526,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1485,"B2","FLCN","FLCN","del.","thyroid","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","case report",25295501,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1486,"B2","HGF","HGF","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-ampl","Trastuzumab In HER2-ampl","her2 inhibitor","early trials",22850551,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1487,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25232318,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1487,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25232318,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1488,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1488,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1489,"B2","MET","MET","ampl.","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1489,"B2","MET","MET","ampl.","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1490,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1490,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1491,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1491,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1494,"B2","MET","MET","ampl.","hepatocellular_carcinoma","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","case report","ENA 2015 (abstract A55)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1495,"B2","MET","MET","ampl.","Gastric Adenocarcinoma","ampl.","sensitivity/response","Onartuzumab","Onartuzumab","met inhibitor","case report",22389872,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1500,"B2","MET","MET","ampl.","glioma","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",22162573,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1500,"B2","MET","MET","ampl.","glioma","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1507,"B2","MET","MET","ampl.","Non-Small Cell Lung Cancer","ampl., D1010H, D1010N, D1010Y, Exon 14 del., Exon 14 splice any mut., Y1003C, Y1003F, Y1003N","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials","21623265, 25971939, 26729443","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1507,"B2","MET","MET","ampl.","Non-Small Cell Lung Cancer","ampl., D1010H, D1010N, D1010Y, Exon 14 del., Exon 14 splice any mut., Y1003C, Y1003F, Y1003N","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials","21623265, 25971939, 26729443","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1508,"B2","MET","MET","ampl.","Stomach Carcinoma","ampl. (overexpr.)","sensitivity/response","Rilotumumab","Rilotumumab","hgf antibody","clin. trials",28958504,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1509,"B2","MET","MET","ampl.","Skin Melanoma","ampl. (overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","clin. trials","26359985, 23802768","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1510,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","resistance","EGFR TKIs (EGFR Mut Disease)","EGFR TKIs","egfr inhibitor","early trials","ASCO 2015 (abstr 8089)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1511,"B2","MET","MET","ampl.","gastric","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","ASCO GI 2015 (abstr 1)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1512,"B2","MET","MET","ampl.","renal","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","23213094, AACR 2016 (abstr CT2006)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1513,"B2","MET","MET","ampl.","colorectal","ampl. (GoF)","resistance","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","early trials",23729478,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1514,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1514,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1515,"B2","MET","MET","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-amplified","Trastuzumab In HER2-amplified","her2 inhibitor","early trials",22850551,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1516,"B2","NTRK1","NTRK1","ampl.","Solid Tumor","ampl.","sensitivity/response","Larotrectinib","Larotrectinib","trk inhibitor","case report",30624546,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1517,"B2","NTRK1","NTRK1","ampl.","Cancer","fusion, ampl.","sensitivity/response","Entrectinib","Entrectinib","trk inhibitor","clin. trials",28183697,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1521,"B2","TOP1","TOP1","ampl.","Colorectal Cancer","ampl., ampl. (expr.)","sensitivity/response","Irinotecan","Irinotecan","topoisomerase inhibitor","clin. trials","24256029, 19775480","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1522,"B2","TYMS","TYMS","del.","Prostate Cancer","del. (underexpr.)","sensitivity/response","Pemetrexed","Pemetrexed","antimetabolite","case report",24782778,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1523,"B2","TYMS","TYMS","del.","Lung Non-small Cell Carcinoma","del. (underexpr.)","sensitivity/response","Pemetrexed","Pemetrexed","antimetabolite","clin. trials",21367480,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1528,"B3","ABCB1","ABCB1","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",21883677,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1529,"B3","ASNS","ASNS","ampl.","Ovarian Cancer","ampl.","resistance","Asparaginase","Asparaginase","asparaginase","preclinical",17088436,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1530,"B3","AURKA","AURKA","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","AURK Inhibitors","AURK Inhibitors","aurk inhibitor","preclinical",22302096,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1531,"B3","AURKA","AURKA","ampl.","prostate","ampl. (GoF)","sensitivity","AURK Inhibitors","AURK Inhibitors","aurk inhibitor","preclinical",22389870,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1532,"B3","AURKA","AURKA","ampl.","Cervical Adenocarcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",12559175,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1533,"B3","BCL2","BCL2","ampl.","lymphoma","ampl. (GoF)","sensitivity","BCL2 Inhibitors","BCL2 Inhibitors","bcl2 inhibitor","preclinical",22649144,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1534,"B3","BIRC7","BIRC7","ampl.","Colon Cancer","ampl.","resistance","Cisplatin","Cisplatin","platinum","preclinical",23188704,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1535,"B3","CDK6","CDK6","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK6 Inhibitors","CDK6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1536,"B3","CDK6","CDK6","ampl.","Glioblastoma Proneural Subtype","ampl. (overexpr.)","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",28903422,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1541,"B3","EGFR","EGFR","ampl.","Glioma","A289V, ampl., R108K, T263P","sensitivity/response","Lapatinib","Lapatinib","egfr inhibitor","preclinical","18334972, 20459769, 22588883","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1541,"B3","EGFR","EGFR","ampl.","Glioma","A289V, ampl., R108K, T263P","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","preclinical","18334972, 20459769, 22588883","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1544,"B3","HGF","HGF","ampl.","Glioblastoma","ampl. (expr.)","sensitivity/response","MET Tyrosine Kinase Inhibitor SGX523","MET Tyrosine Kinase Inhibitor SGX523","met inhibitor","preclinical",22203985,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1545,"B3","HSPB1","HSPB1","ampl.","Pancreatic Ductal Adenocarcinoma","ampl. (expr.)","sensitivity/response","Gemcitabine","Gemcitabine","antimetabolite","preclinical",22004109,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1546,"B3","IL6","IL6","ampl.","Rhabdomyosarcoma","ampl. (overexpr.)","resistance","Bazedoxifene","Bazedoxifene","anti-estrogen","preclinical",28672024,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1547,"B3","INPP4B","INPP4B","del.","breast","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",23551093,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1548,"B3","MCL1","MCL1","ampl.","cancer_unspecified","ampl. (GoF)","resistance","Anti-tubulin Agents","Anti-tubulin Agents","alkaloid","preclinical",21368834,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1549,"B3","MDM4","MDM4","ampl.","sarcoma","ampl. (GoF)","sensitivity","MDM2/MDMX Inhibitors","MDM2/MDMX Inhibitors","mdm2/mdmx inhibitor","preclinical",24336067,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1550,"B3","MET","MET","ampl.","Colorectal Cancer","ampl.","resistance","Anti-EGFR Monoclonal Antibody","Anti-EGFR Monoclonal Antibody","egfr inhibitor","preclinical",23729478,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1551,"B3","MET","MET","ampl.","colorectal","ampl. (GoF)","sensitivity","BCL2 Inhibitors","BCL2 Inhibitors","bcl2 inhibitor","preclinical",27397505,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1552,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",21716144,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1552,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",21716144,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1553,"B3","MET","MET","ampl.","Uveal Melanoma","ampl. (overexpr.)","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",24140933,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1553,"B3","MET","MET","ampl.","Uveal Melanoma","ampl. (overexpr.)","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",24140933,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1556,"B3","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl.","resistance","Gefitinib","Gefitinib","egfr inhibitor","preclinical",17463250,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1557,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","sensitivity","MET Inhibitors","MET Inhibitors","met inhibitor","preclinical","22729845, 23327903","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1560,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","egfr inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1560,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","her2 inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1561,"B3","MYC","MYC","ampl.","myeloma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",21889194,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1562,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",23430699,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS10.csv","PTCL-NOS10","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1616,"B3","AKT3","AKT3","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Akt Inhibitor MK2206","Akt Inhibitor MK2206","pi3k/akt inhibitor","preclinical",27297869,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS12.csv","PTCL-NOS12","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1694,"B2","CDK6","CDK6","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","clin. trials",27252418,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS13.csv","PTCL-NOS13","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1734,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","met inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS13.csv","PTCL-NOS13","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1821,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","FACT Inhibitor","FACT Inhibitor","fact inhibitor","preclinical",26537256,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS13.csv","PTCL-NOS13","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1859,"B3","PTEN","PTEN","del.","Endometrial Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",23674493,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS13.csv","PTCL-NOS13","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[1912,"B2","SGK1","SGK1","ampl.","Breast Cancer","ampl. (overexpr.)","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","clin. trials",27451907,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS15.csv","PTCL-NOS15","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2046,"B2","ERBB2","ERBB2","ampl.","endometrial","ampl. (GoF)","no response","Trastuzumab Alone","Trastuzumab Alone","her2 inhibitor","early trials",19840887,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS16.csv","PTCL-NOS16","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2135,"B3","CDKN2A","CDKN2A","del.","glioma","any variant (LoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical","22586120, 22711607","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS16.csv","PTCL-NOS16","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2193,"B3","NOTCH1","NOTCH1","del.","Head And Neck Squamous Cell Carcinoma","(LoF)","sensitivity/response","Porcupine Inhibitor WNT974","Porcupine Inhibitor WNT974","wnt inhibitor","preclinical",24277854,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS16.csv","PTCL-NOS16","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[2262,"B2","PTEN","PTEN","del.","prostate","any variant (LoF)","response","PI3K Beta Inhibitor","PI3K Beta Inhibitor","pi3k/akt inhibitor","case report","ASCO 2014 (abstr 2514 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS18.csv","PTCL-NOS18","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2353,"B3","PTEN","PTEN","del.","Prostate Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",11504908,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS18.csv","PTCL-NOS18","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2377,"B2","CDKN2A","CDKN2A","del.","melanoma","any variant (LoF)","response","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","case report","ASCO 2013 (abstr 2500)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS19.csv","PTCL-NOS19","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2488,"B3","FGFR1","FGFR1","ampl.","Ewing Sarcoma Of Bone","ampl.","sensitivity/response","Ponatinib","Ponatinib","multi TKI","preclinical",26179511,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS19.csv","PTCL-NOS19","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2538,"B3","PTEN","PTEN","del.","lung","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",23136191,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS19.csv","PTCL-NOS19","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2629,"B2","EGFR","EGFR","ampl.","Head And Neck Squamous Cell Carcinoma","ampl. (overexpr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",23265711,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS1.csv","PTCL-NOS1","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2670,"B2","MET","MET","ampl.","hepatocellular_carcinoma","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","case report","ENA 2015 (abstract A55)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS1.csv","PTCL-NOS1","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2732,"B3","CDKN2A","CDKN2A","del.","Skin Melanoma","loss","sensitivity/response","Alvocidib","Alvocidib","multi CDK inhibitor","preclinical",12777976,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS1.csv","PTCL-NOS1","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2806,"B3","STK11","STK11","del.","cancer_unspecified","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS1.csv","PTCL-NOS1","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2863,"B2","FGF19","FGF19","ampl.","Hepatocellular Carcinoma","ampl. (overexpr.)","sensitivity/response","Fisogatinib","Fisogatinib","fgfr inhibitor","clin. trials",31575541,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS20.csv","PTCL-NOS20","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[2971,"B3","CDKN2A","CDKN2A","del.","Skin Melanoma","loss","sensitivity/response","Alvocidib","Alvocidib","multi CDK inhibitor","preclinical",12777976,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS20.csv","PTCL-NOS20","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3009,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","egfr inhibitor","preclinical",22238368,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS20.csv","PTCL-NOS20","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3110,"B2","CDKN2A","CDKN2A","del.","Lung Non-small Cell Carcinoma","loss","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","clin. trials",174591,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS21.csv","PTCL-NOS21","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3157,"B2","ERBB2","ERBB2","ampl.","Her2-receptor Positive Breast Cancer","ampl.","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","clin. trials","22418700, 26596672, 26822398","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS21.csv","PTCL-NOS21","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3297,"B2","PTEN","PTEN","del.","Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",28330462,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS21.csv","PTCL-NOS21","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3363,"B3","ERBB2","ERBB2","ampl.","Her2-receptor Positive Breast Cancer","ampl.","sensitivity/response","A66","A66","pi3k/akt inhibitor","preclinical",22802530,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS21.csv","PTCL-NOS21","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3433,"B3","NOTCH1","NOTCH1","del.","Head And Neck Squamous Cell Carcinoma","(LoF)","sensitivity/response","Porcupine Inhibitor WNT974","Porcupine Inhibitor WNT974","wnt inhibitor","preclinical",24277854,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS21.csv","PTCL-NOS21","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[3474,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS21.csv","PTCL-NOS21","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3565,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS22.csv","PTCL-NOS22","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3598,"B3","ASNS","ASNS","ampl.","Ovarian Cancer","ampl.","resistance","Asparaginase","Asparaginase","asparaginase","preclinical",17088436,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS22.csv","PTCL-NOS22","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3706,"B2","NF2","NF2","del.","mesothelioma","any variant (LoF)","response","FAK Inhibitors","FAK Inhibitors","fak inhibitor","early trials","ENA 2012 (abstr 610)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS23.csv","PTCL-NOS23","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3758,"B2","SSTR5","SSTR5","ampl.","Neuroendocrine Tumor","ampl. (expr.)","sensitivity/response","Pasireotide","Pasireotide",null,"clin. trials",25376618,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS23.csv","PTCL-NOS23","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3825,"B3","PTEN","PTEN","del.","glioma","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","21325073, 21191045, 17804702","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS23.csv","PTCL-NOS23","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3890,"B3","DNMT1","DNMT1","ampl.","Ovarian Cancer","ampl. (expr.)","sensitivity/response","Decitabine","Decitabine","demethylating agent","preclinical",25968887,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS24.csv","PTCL-NOS24","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[3949,"B2","ERBB2","ERBB2","ampl.","Endometrial Serous Adenocarcinoma","ampl.","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","case report",18555254,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS25.csv","PTCL-NOS25","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4071,"B2","NTRK1","NTRK1","ampl.","Cancer","fusion, ampl.","sensitivity/response","Entrectinib","Entrectinib","trk inhibitor","clin. trials",28183697,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS25.csv","PTCL-NOS25","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4095,"B3","BRCA1","BRCA1","ampl.","Malignant Mesothelioma","ampl. (expr.)","sensitivity/response","Vinorelbine","Vinorelbine","alkaloid","preclinical",22190288,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS25.csv","PTCL-NOS25","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4188,"B2","FLCN","FLCN","del.","renal","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","case report",23995526,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS26.csv","PTCL-NOS26","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4227,"B1","ERBB2","ERBB2","ampl.","Esophagogastric Cancer","ampl.","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","approved",20728210,"OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS27.csv","PTCL-NOS27","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4336,"B3","ERBB2","ERBB2","ampl.","Uterine Corpus Endometrial Carcinoma","ampl.","sensitivity/response","Afatinib","Afatinib","egfr inhibitor","preclinical",25268372,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS27.csv","PTCL-NOS27","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4419,"B2","EGFR","EGFR","ampl.","Colorectal Cancer","ampl. (expr.)","sensitivity/response","Panitumumab","Panitumumab","egfr inhibitor","clin. trials",17470858,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS28.csv","PTCL-NOS28","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4463,"B2","MET","MET","ampl.","renal","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","23213094, AACR 2016 (abstr CT2006)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS28.csv","PTCL-NOS28","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4544,"B3","PIK3CA","PIK3CA","ampl.","breast","ampl. (GoF)","resistance","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",24366379,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS28.csv","PTCL-NOS28","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4569,"B2","CDK6","CDK6","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","clin. trials",27252418,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS29.csv","PTCL-NOS29","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4691,"B3","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","MEK Inhibitors In BRAF Mutant Tumors","MEK Inhibitors In BRAF Mutant Tumors","mek inhibitor","preclinical",23039341,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS29.csv","PTCL-NOS29","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4748,"B2","CDK6","CDK6","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","clin. trials",27252418,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS30.csv","PTCL-NOS30","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4870,"B2","TOP2A","TOP2A","ampl.","breast","ampl. (GoF)","response","Anthracyclines","Anthracyclines","anthracyclin","late trials",22864769,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS30.csv","PTCL-NOS30","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4924,"B3","MYC","MYC","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","JQ-1","JQ-1","bet inhibitor","preclinical",21889194,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS30.csv","PTCL-NOS30","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[4979,"B2","BRCA2","BRCA2","del.","Prostate Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials",26510020,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS32.csv","PTCL-NOS32","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[5127,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","early trials","ASCO 2014 (abstr 8001), ASCO 2015 (abstr 2595)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS32.csv","PTCL-NOS32","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5143,"B3","ABCB1","ABCB1","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",21883677,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS32.csv","PTCL-NOS32","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5241,"B3","RB1","RB1","del.","Glioblastoma","(LoF)","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",20354191,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS32.csv","PTCL-NOS32","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[5268,"B2","CDKN2A","CDKN2A","del.","melanoma","any variant (LoF)","response","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","case report","ASCO 2013 (abstr 2500)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS33.csv","PTCL-NOS33","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5378,"B2","SLC29A1","SLC29A1","ampl.","Pancreatic Adenocarcinoma","ampl. (overexpr.)","sensitivity/response","Gemcitabine","Gemcitabine","antimetabolite","clin. trials",22705007,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS34.csv","PTCL-NOS34","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5463,"B2","MET","MET","ampl.","lung_adeno","ampl. (GoF)","resistance","EGFR TKIs (EGFR Mut Disease)","EGFR TKIs","egfr inhibitor","early trials","ASCO 2015 (abstr 8089)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS35.csv","PTCL-NOS35","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5513,"B3","ERBB2","ERBB2","del.","breast","755-759del (GoF)","sensitivity","Neratinib","Neratinib","her2 inhibitor","preclinical",23220880,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS36.csv","PTCL-NOS36","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[5586,"B2","PTEN","PTEN","del.","prostate","any variant (LoF)","response","PI3K Beta Inhibitor","PI3K Beta Inhibitor","pi3k/akt inhibitor","case report","ASCO 2014 (abstr 2514 )","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS37.csv","PTCL-NOS37","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5665,"B3","BRCA1","BRCA1","del.","ovarian","del. (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",22392482,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS37.csv","PTCL-NOS37","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5727,"B3","PTEN","PTEN","del.","ovarian","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",21632463,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS37.csv","PTCL-NOS37","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5827,"B2","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","sensitivity/response","Lucitanib","Lucitanib","fgfr inhibitor","clin. trials",25193991,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS39.csv","PTCL-NOS39","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5860,"B2","NRG1","NRG1","ampl.","Lung Non-small Cell Carcinoma","ampl. (expr.)","sensitivity/response","Patritumab","Patritumab","her3 inhibitor","clin. trials",26137564,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS39.csv","PTCL-NOS39","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5952,"B2","CTAG2","CTAG2","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","Letetresgene Autoleucel","Letetresgene Autoleucel",null,"clin. trials",26193344,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS40.csv","PTCL-NOS40","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[5995,"B2","MITF","MITF","ampl.","melanoma","ampl. (GoF)","resistance","BRAF Inhibitors","BRAF Inhibitors","raf inhibitor","case report",24265153,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS43.csv","PTCL-NOS43","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6065,"B2","ERBB2","ERBB2","ampl.","Her2-receptor Positive Breast Cancer","ampl.","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","clin. trials","22418700, 26596672, 26822398","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS46.csv","PTCL-NOS46","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6156,"B3","BRCA1","BRCA1","ampl.","Malignant Mesothelioma","ampl. (expr.)","sensitivity/response","Vinorelbine","Vinorelbine","alkaloid","preclinical",22190288,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS46.csv","PTCL-NOS46","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6197,"B3","PARP1","PARP1","ampl.","Malignant Peripheral Nerve Sheath Tumor","ampl. (overexpr.)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",26650448,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS46.csv","PTCL-NOS46","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6356,"B2","MET","MET","ampl.","gastric","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","ASCO GI 2015 (abstr 1)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS48.csv","PTCL-NOS48","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6381,"B3","BRCA1","BRCA1","ampl.","Malignant Mesothelioma","ampl. (expr.)","sensitivity/response","Vinorelbine","Vinorelbine","alkaloid","preclinical",22190288,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS48.csv","PTCL-NOS48","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6483,"B2","EGFR","EGFR","ampl.","Colorectal Cancer","ampl., ampl. (expr.)","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials","18794099, 18003960, 14993230","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS4.csv","PTCL-NOS4","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6533,"B2","MET","MET","ampl.","Non-Small Cell Lung Cancer","ampl., D1010H, D1010N, D1010Y, Exon 14 del., Exon 14 splice any mut., Y1003C, Y1003F, Y1003N","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials","21623265, 25971939, 26729443","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS4.csv","PTCL-NOS4","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6606,"B3","CDKN1B","CDKN1B","del.","cancer_unspecified","any variant (LoF)","sensitivity","CDK2/4 Inhibitors","CDK2/4 Inhibitors","cdk2/4 inhibitor","preclinical",22471707,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS4.csv","PTCL-NOS4","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6657,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","pi3k/akt inhibitor","preclinical",19010894,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS4.csv","PTCL-NOS4","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6757,"B3","SUZ12","SUZ12","del.","cancer_unspecified","any variant (LoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",25119042,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS53.csv","PTCL-NOS53","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6861,"B2","ERBB2","ERBB2","ampl.","endometrial","ampl. (GoF)","no response","Trastuzumab Alone","Trastuzumab Alone","her2 inhibitor","early trials",19840887,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS56.csv","PTCL-NOS56","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[6878,"B3","ERBB2","ERBB2","ampl.","Uterine Corpus Endometrial Carcinoma","ampl.","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","preclinical",25268372,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS56.csv","PTCL-NOS56","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7002,"B3","EGFR","EGFR","ampl.","Glioma","A289V, ampl., R108K, T263P","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","preclinical","18334972, 20459769, 22588883","OncoKB","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS57.csv","PTCL-NOS57","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7039,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","PI3Ka/Di","PI3Ka/Di","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS57.csv","PTCL-NOS57","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7127,"B3","PAK1","PAK1","ampl.","melanoma","ampl. (GoF)","sensitivity","PAK Inhibitors","PAK Inhibitors","pak inhibitor","preclinical",23535073,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS59.csv","PTCL-NOS59","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7162,"B2","ERBB2","ERBB2","ampl.","gastric","ampl. (GoF)","response","Afatinib","Afatinib","egfr inhibitor","case report","AACR 2014 (abstr CT228)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS60.csv","PTCL-NOS60","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7253,"B3","ERBB2","ERBB2","ampl.","Colorectal Cancer","ampl.","sensitivity/response","Afatinib","Afatinib","her2 inhibitor","preclinical",26296355,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS60.csv","PTCL-NOS60","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7395,"B2","MET","MET","ampl.","Glioblastoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",22162573,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS65.csv","PTCL-NOS65","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7398,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",24192513,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS65.csv","PTCL-NOS65","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7522,"B2","CDK6","CDK6","ampl.","Estrogen-receptor Positive Breast Cancer","ampl. (overexpr.)","resistance","Fulvestrant","Fulvestrant","anti-estrogen","clin. trials",27252418,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS7.csv","PTCL-NOS7","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7552,"B2","EGFR","EGFR","ampl.","colorectal","ampl. (GoF)","response","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","late trials","18794099, 17664472","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS7.csv","PTCL-NOS7","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7691,"B2","MET","MET","ampl.","renal","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","23213094, AACR 2016 (abstr CT2006)","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS7.csv","PTCL-NOS7","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7706,"B2","PTEN","PTEN","del.","Pancreatic Carcinoma","loss","sensitivity/response","Akt Inhibitor MK2206","Akt Inhibitor MK2206","pi3k/akt inhibitor","case report",22025163,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS7.csv","PTCL-NOS7","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7837,"B3","FGFR1","FGFR1","ampl.","Lung Cancer","ampl. (expr.)","sensitivity/response","Ponatinib","Ponatinib","multi TKI","preclinical",24771645,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS7.csv","PTCL-NOS7","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7903,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","PI3Ka/Di","PI3Ka/Di","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS7.csv","PTCL-NOS7","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[7966,"B2","EGFR","EGFR","ampl.","head_neck","ampl. (GoF)","response","EGFR Inhibitors","EGFR Inhibitors","egfr inhibitor","case report",26763254,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS8.csv","PTCL-NOS8","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8016,"B2","ERBB2","ERBB2","ampl.","Lung Non-small Cell Carcinoma","ampl., Y772-A775DUP","sensitivity/response","Dacomitinib","Dacomitinib","egfr inhibitor","clin. trials",25899785,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS8.csv","PTCL-NOS8","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8088,"B2","KIT","KIT","ampl.","Mucosal Melanoma","ampl.","resistance","Imatinib","Imatinib","bcr-abl inhibitor","clin. trials",23775962,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS8.csv","PTCL-NOS8","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8169,"B2","TOP2A","TOP2A","ampl.","breast","ampl. (GoF)","response","Anthracyclines","Anthracyclines","anthracyclin","late trials",22864769,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS8.csv","PTCL-NOS8","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8260,"B3","NF2","NF2","del.","meningioma, PEComa","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical","19451225, 22426462, 22927055","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS8.csv","PTCL-NOS8","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8295,"B3","PTEN","PTEN","del.","Prostate Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",11504908,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS8.csv","PTCL-NOS8","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8390,"B3","RB1","RB1","del.","retinoblastoma","any variant (LoF)","sensitivity","MDM2/MDMX Inhibitors","MDM2/MDMX Inhibitors","mdm2/mdmx inhibitor","preclinical","17080083, 21515735","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-NOS9.csv","PTCL-NOS9","Patient","lymphoma","NOS","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8459,"B2","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","sensitivity/response","Lucitanib","Lucitanib","vegf inhibitor","clin. trials",25193991,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH1.csv","PTCL-TFH1","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8477,"B3","AKT1","AKT1","ampl.","Melanoma","Q79K, E17K, ampl. (Overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical","24265152, 24265155","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH1.csv","PTCL-TFH1","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8529,"B3","NRG1","NRG1","ampl.","Cancer","ampl. (expr.)","sensitivity/response","Anti-ErbB3 Monoclonal Antibody AV-203","Anti-ErbB3 Monoclonal Antibody AV-203","her3 inhibitor","preclinical",25542901,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH1.csv","PTCL-TFH1","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8610,"B2","MET","MET","ampl.","Gastric Adenocarcinoma","ampl.","sensitivity/response","Onartuzumab","Onartuzumab","met inhibitor","case report",22389872,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH2.csv","PTCL-TFH2","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8726,"B2","EGFR","EGFR","del.","Lung Adenocarcinoma","L858R, Exon 19 del.","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","clin. trials","23816960, 22452895, 24439929, 25589191","CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH3.csv","PTCL-TFH3","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8762,"B3","PBRM1","PBRM1","del.","cancer_unspecified","any variant (LoF)","sensitivity","EZH2 Inhibitor In RAS Wt","EZH2 Inhibitor In RAS Wt","ezh2 inhibitor","preclinical",26552009,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH3.csv","PTCL-TFH3","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8856,"B2","PTEN","PTEN","del.","Pancreatic Carcinoma","loss","sensitivity/response","Akt Inhibitor MK2206","Akt Inhibitor MK2206","pi3k/akt inhibitor","case report",22025163,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH6.csv","PTCL-TFH6","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8880,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","BRAF Inhibitors In BRAF Mutant Tumor","BRAF Inhibitors In BRAF Mutant Tumor","raf inhibitor","early trials","http://ascopubs.org/doi/abs/10.1200/PO.16.00054","GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH6.csv","PTCL-TFH6","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[8947,"B3","RB1","RB1","del.","Breast Cancer","(LoF)","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",20473330,"CIVIC","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH6.csv","PTCL-TFH6","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0]
[9017,"B3","CD274","CD274","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","preclinical",25079317,"GDKD","Heavican_et_al_19_CNV_Microarr_CNV_NA_PTCL-TFH9.csv","PTCL-TFH9","Patient","lymphoma","NOS (TFH)","CNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Microarray",{"$nulls":5},"NONE","NONE",0,"x"]
[9115,"B3","CDKN2A","CDKN2A","del.","cancer_unspecified","any variant (LoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Kataoka_et_al_15_WGS_Deletions_CNV_ATLL_ATL035.csv","ATL035","Patient","lymphoma","ATLL","CNV","10.1038/ng.3415","Kataoka_et_al_15","WGS",{"$nulls":5},"NONE","NONE",0,"x"]
[9215,"B3","STK11","STK11","del.","Peutz-Jeghers Syndrome","loss","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical","18281551, 19541609","CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_10.csv",10,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9262,"B3","MYC","MYC","ampl.","myeloma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",21889194,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_11.csv",11,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9367,"B3","FGFR1","FGFR1","ampl.","Ewing Sarcoma Of Bone","ampl.","sensitivity/response","Ponatinib","Ponatinib","multi TKI","preclinical",26179511,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_13.csv",13,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9384,"B3","MYC","MYC","ampl.","prostate","ampl. (GoF)","sensitivity","PIM Inhibitors","PIM Inhibitors","pim inhibitor","preclinical",25505253,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_13.csv",13,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9505,"B3","MYC","MYC","ampl.","neuroblastoma","ampl. (GoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",23430699,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_14.csv",14,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9576,"B3","PTEN","PTEN","del.","endometrial","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",22662154,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_15.csv",15,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9645,"B2","CDKN2A","CDKN2A","del.","Lung Non-small Cell Carcinoma","loss","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","clin. trials",174591,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_17.csv",17,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9693,"B3","RB1","RB1","del.","retinoblastoma","any variant (LoF)","sensitivity","HDAC Inhibitors","HDAC Inhibitors","hdac inhibitor","preclinical",18483379,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_17.csv",17,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9731,"B2","HGF","HGF","ampl.","breast","ampl. (GoF)","resistance","Trastuzumab In HER2-ampl","Trastuzumab In HER2-ampl","her2 inhibitor","early trials",22850551,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_18.csv",18,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9818,"B3","MYC","MYC","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","JQ-1","JQ-1","bet inhibitor","preclinical",21889194,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_18.csv",18,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9847,"B2","CTAG1B","CTAG1A","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","Letetresgene Autoleucel","Letetresgene Autoleucel",null,"clin. trials",26193344,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_19.csv",19,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[9969,"B3","ERCC1","ERCC1","del.","lung","any variant (LoF)","sensitivity","Cisplatin","Cisplatin","platinum","preclinical","23275151, 23934192","GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_1.csv",1,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10010,"B3","ATM","ATM","del.","Gastric Adenocarcinoma","del. (underexpr.)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24841718,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_20.csv",20,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10065,"B2","PIK3CA","PIK3CA","ampl.","Epithelial Ovarian Cancer","ampl.","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","case report",25370471,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_22.csv",22,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10137,"B2","ATM","ATM","del.","gastric","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","ENA 2014 (abstr 8LBA)","GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_23.csv",23,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10182,"B2","ATM","ATM","del.","colorectal","any variant (LoF)","response","ATR Inhibitors","ATR Inhibitors","atr inhibitor","case report","ENA 2015 (abstract A48)","GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_24.csv",24,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10258,"B2","FGFR1","FGFR1","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","clin. trials",27870574,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_25.csv",25,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10356,"B2","PTEN","PTEN","del.","Bladder Carcinoma","loss","resistance","Everolimus","Everolimus","mtor inhibitor","clin. trials",23989949,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_26.csv",26,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10404,"B3","FOXA1","FOXA1","ampl.","colorectal","ampl. (GoF)","sensitivity","BCL2 Inhibitors","BCL2 Inhibitors","bcl2 inhibitor","preclinical",27397505,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_26.csv",26,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10428,"B3","PTEN","PTEN","del.","breast","any variant (LoF)","sensitivity","ATM Inhibitor","ATM Inhibitor","atm inhibitor","preclinical",27397505,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_26.csv",26,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10497,"B2","MGMT","MGMT","del.","High Grade Glioma","del. (underexpr.)","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","clin. trials",21365007,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_27.csv",27,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10556,"B3","FGFR1","FGFR1","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","PD173074","PD173074","vegf inhibitor","preclinical",21160078,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_27.csv",27,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10620,"B3","RB1","RB1","del.","Glioblastoma","(LoF)","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",20354191,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_27.csv",27,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0]
[10703,"B3","MAGEH1","MAGEH1","ampl.","Bile Duct Adenocarcinoma","ampl. (expr.)","resistance","Gemcitabine","Gemcitabine","antimetabolite","preclinical",20088962,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_28.csv",28,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10787,"B2","MET","MET","ampl.","Lung Non-small Cell Carcinoma","ampl., EXON 14 any mut. and ampl., EXON 14 SKIPPING any mut., MET::ATXN7L1","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","21623265, 26729443, 27664533, 26892698, 30339198","CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_29.csv",29,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10830,"B3","FGFR1","FGFR1","ampl.","Breast Cancer","ampl.","resistance","Afimoxifene","Afimoxifene","anti-estrogen","preclinical",20179196,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_29.csv",29,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10927,"B3","AKT3","AKT3","ampl.","Melanoma","E17K, ampl. (Overexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_30.csv",30,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[10957,"B2","CCND1","CCND1","ampl.","lung","ampl. (GoF)","no response","Palbociclib","Palbociclib","cdk4/6 inhibitor","early trials","ASCO 2017 (abstr 9056)","GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_31.csv",31,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11051,"B2","ERBB2","ERBB2","ampl.","endometrial","ampl. (GoF)","no response","Trastuzumab Alone","Trastuzumab Alone","her2 inhibitor","early trials",19840887,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_31.csv",31,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11112,"B3","CCND1","CCND1","ampl.","cancer_unspecified","ampl. (GoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_31.csv",31,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11188,"B3","MAPK1","MAPK1","ampl.","Lung Non-small Cell Carcinoma","ampl.","resistance","WZ4002","WZ4002","egfr inhibitor","preclinical",22961667,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_31.csv",31,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11303,"B3","FGFR1","FGFR1","ampl.","head_neck","ampl. (GoF)","sensitivity","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","preclinical",23418312,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_32.csv",32,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11328,"B3","NF2","NF2","del.","Thyroid Gland Carcinoma","loss","sensitivity/response","Selumetinib","Selumetinib","mek inhibitor","preclinical",26359368,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_32.csv",32,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11419,"B3","FGFR1","FGFR1","ampl.","Ewing Sarcoma Of Bone","ampl.","sensitivity/response","Ponatinib","Ponatinib","multi TKI","preclinical",26179511,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_34.csv",34,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11443,"B3","ATM","ATM","del.","Gastric Adenocarcinoma","del. (underexpr.)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24841718,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_35.csv",35,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11553,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","PD1 Inhibitors","PD1 Inhibitors","pd1/pdl1 antibody","early trials",26645196,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_37.csv",37,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11595,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","her2 inhibitor","preclinical",22238368,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_37.csv",37,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11658,"B2","EGFR","EGFR","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.), ampl.","sensitivity/response","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","egfr inhibitor","clin. trials","22056021, 26439803, 20826716","CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_39.csv",39,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11729,"B3","IL6","IL6","ampl.","Rhabdomyosarcoma","ampl. (overexpr.)","resistance","Bazedoxifene","Bazedoxifene","anti-estrogen","preclinical",28672024,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_39.csv",39,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11777,"B3","ASS1","ASS1","del.","Ovarian Cancer","loss","resistance","Platinum Compound","Platinum Compound","platinum","preclinical",19533750,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_3.csv",3,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11866,"B2","VEGFA","VEGFA","ampl.","hepatocellular_carcinoma","ampl. (GoF)","response","Sorafenib","Sorafenib","multi TKI","early trials",24687604,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_40.csv",40,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[11897,"B3","MYC","MYC","ampl.","prostate","ampl. (GoF)","sensitivity","PIM Inhibitors","PIM Inhibitors","pim inhibitor","preclinical",25505253,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_40.csv",40,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[12007,"B2","CD274","CD274","ampl.","Lung Non-small Cell Carcinoma","ampl. (expr.)","sensitivity/response","Pembrolizumab","Pembrolizumab","pd1/pdl1 antibody","clin. trials","27718847, 25891174","CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_7.csv",7,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[12047,"B3","FGFR1","FGFR1","ampl.","Gastric Adenocarcinoma","ampl. (expr.)","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","preclinical",26637881,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_7.csv",7,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[12110,"B2","TSC1","TSC1","del.","Bladder Carcinoma","(LoF)","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",22923433,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_8.csv",8,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0]
[12174,"B3","SMARCB1","SMARCB1","del.","Rhabdoid Cancer","del.","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",23620515,"CIVIC","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_8.csv",8,"Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[12242,"B2","ATM","ATM","del.","colorectal","any variant (LoF)","response","ATR Inhibitors","ATR Inhibitors","atr inhibitor","case report","ENA 2015 (abstract A48)","GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_index1.csv","index1","Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[12316,"B2","FANCA","FANCA","del.","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Kiel_et_al_14_CNV_aCGH_CNV_T-PLL_PLL_index2.csv","index2","Patient","lymphoma","T-PLL","CNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","aCGH",{"$nulls":5},"NONE","NONE",0,"x"]
[12444,"B3","PTEN","PTEN","del.","breast","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","23085766, 22932669","GDKD","Maura_et_al_21_CNV_B11-2264.csv","B11-2264","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[12474,"B3","CDKN2A","CDKN2A","del.","glioma","any variant (LoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical","22586120, 22711607","GDKD","Maura_et_al_21_CNV_B12-5470.csv","B12-5470","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH + WGS",{"$nulls":5},"NONE","NONE",0,"x"]
[12515,"B2","PTEN","PTEN","del.","Prostate Cancer","del.","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",23582881,"CIVIC","Maura_et_al_21_CNV_I01-314114.csv","I01-314114","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[12606,"B2","PTEN","PTEN","del.","Colorectal Cancer","loss","resistance","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",21163703,"CIVIC","Maura_et_al_21_CNV_S07-16858.csv","S07-16858","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[12675,"B3","PTEN","PTEN","del.","Melanoma","loss","sensitivity/response","Uprosertib","Uprosertib","pi3k/akt inhibitor","preclinical",24735930,"CIVIC","Maura_et_al_21_CNV_S07-16858.csv","S07-16858","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[12767,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","mtor inhibitor","preclinical",19010894,"CIVIC","Maura_et_al_21_CNV_S10-10646.csv","S10-10646","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH + WGS",{"$nulls":5},"NONE","NONE",0,"x"]
[12831,"B2","PTEN","PTEN","del.","melanoma","any variant (LoF)","resistance","PD1 Inhibitors","PD1 Inhibitors","pd1/pdl1 antibody","early trials",26645196,"GDKD","Maura_et_al_21_CNV_S13-6917.csv","S13-6917","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","WGS",{"$nulls":5},"NONE","NONE",0,"x"]
[12912,"B2","PTEN","PTEN","del.","Stomach Carcinoma","loss","resistance","Chemotherapy","Chemotherapy",null,"clin. trials",15900596,"CIVIC","Maura_et_al_21_CNV_S15-8245.csv","S15-8245","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[12960,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","PI3Ka/Di","PI3Ka/Di","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Maura_et_al_21_CNV_S15-8245.csv","S15-8245","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13004,"B2","PTEN","PTEN","del.","cancer_unspecified","any variant (LoF)","response","Sirolimus","Sirolimus","mtor inhibitor","early trials","ASCO 2013 (abstr 2532)","GDKD","Maura_et_al_21_CNV_S15-8552.csv","S15-8552","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH + WGS",{"$nulls":5},"NONE","NONE",0,"x"]
[13091,"B3","PTEN","PTEN","del.","Breast Cancer","loss","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",25409150,"CIVIC","Maura_et_al_21_CNV_S15-9252.csv","S15-9252","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13144,"B2","CDKN2A","CDKN2A","del.","Lung Non-small Cell Carcinoma","loss","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","clin. trials",174591,"CIVIC","Maura_et_al_21_CNV_TO-12023.csv","TO-12023","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13238,"B3","PTEN","PTEN","del.","Melanoma","loss","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Maura_et_al_21_CNV_TO-3199.csv","TO-3199","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13316,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Maura_et_al_21_CNV_TO-4519.csv","TO-4519","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13402,"B3","PTEN","PTEN","del.","Endometrial Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",23674493,"CIVIC","Maura_et_al_21_CNV_TO-5058.csv","TO-5058","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13442,"B3","CDKN2A","CDKN2A","del.","Dermatofibrosarcoma Protuberans","loss","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",25852058,"CIVIC","Maura_et_al_21_CNV_TO-9355.csv","TO-9355","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13545,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials","20813970, 21594665","CIVIC","Maura_et_al_21_CNV_TO-9823.csv","TO-9823","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13586,"B3","PTEN","PTEN","del.","glioma","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors (alone Or In Combination)","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","21325073, 21191045, 17804702","GDKD","Maura_et_al_21_CNV_TO-9823.csv","TO-9823","Patient","lymphoma","NOS","CNV","10.3324/haematol.2020.262659","Maura_et_al_21","FISH",{"$nulls":5},"NONE","NONE",0,"x"]
[13659,"B2","MET","MET","ampl.","Lung Squamous Cell Carcinoma","ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",24192513,"CIVIC","Ng_et_al_2018_Supp_7_CNV_DERL-2-1.csv","DERL-2-1","Cell line","lymphoma","HS-TCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[13717,"B3","EGFR","EGFR","del.","Lung Non-small Cell Carcinoma","Exon 19 del., L858R, T790M","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","preclinical","25862853, 26515464, 18408761, 21732342","CIVIC","Ng_et_al_2018_Supp_7_CNV_DERL-2-1.csv","DERL-2-1","Cell line","lymphoma","HS-TCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[13776,"B3","STAG2","STAG2","del.","Melanoma","del. (underexpr.)","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",27500726,"CIVIC","Ng_et_al_2018_Supp_7_CNV_DERL-2-1.csv","DERL-2-1","Cell line","lymphoma","HS-TCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[13884,"B2","HAVCR2","HAVCR2","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.)","resistance","PD1 Inhibitor","PD1 Inhibitor","pd1/pdl1 antibody","case report",26883990,"CIVIC","Ng_et_al_2018_Supp_7_CNV_DL-40-1.csv","DL-40-1","Cell line","lymphoma","ALCL Alk-","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[13943,"B2","TSC1","TSC1","del.","renal","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","case report","24622468, 26859683, ASCO 2015 (abstr 11010), ASCO 2015 (abstr 4519)","GDKD","Ng_et_al_2018_Supp_7_CNV_DL-40-1.csv","DL-40-1","Cell line","lymphoma","ALCL Alk-","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14026,"B3","PTEN","PTEN","del.","endometrial","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",22662154,"GDKD","Ng_et_al_2018_Supp_7_CNV_DL-40-1.csv","DL-40-1","Cell line","lymphoma","ALCL Alk-","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14073,"B2","NTRK1","NTRK1","ampl.","Cancer","fusion, ampl.","sensitivity/response","Entrectinib","Entrectinib","trk inhibitor","clin. trials",28183697,"CIVIC","Ng_et_al_2018_Supp_7_CNV_FEPD-1.csv","FEPD-1","Cell line","lymphoma","ALCL Alk-","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14148,"B3","FGFR1","FGFR1","ampl.","Gastric Adenocarcinoma","ampl. (expr.)","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","preclinical",26637881,"CIVIC","Ng_et_al_2018_Supp_7_CNV_HH.csv","HH","Cell line","lymphoma","CTCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14190,"B3","PIK3CA","PIK3CA","ampl.","Melanoma","E545K, E545G, D350G, ampl.","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Ng_et_al_2018_Supp_7_CNV_HH.csv","HH","Cell line","lymphoma","CTCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14275,"B2","TOP1","TOP1","ampl.","Colorectal Cancer","ampl., ampl. (expr.)","sensitivity/response","Irinotecan","Irinotecan","topoisomerase inhibitor","clin. trials","24256029, 19775480","CIVIC","Ng_et_al_2018_Supp_7_CNV_Karpas-384-1.csv","Karpas-384-1","Cell line","lymphoma","CTCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14327,"B3","MET","MET","ampl.","gastric","ampl. (GoF)","resistance","Lapatinib In HER2-amplified","Lapatinib In HER2-amplified","her2 inhibitor","preclinical",22238368,"GDKD","Ng_et_al_2018_Supp_7_CNV_Karpas-384-1.csv","Karpas-384-1","Cell line","lymphoma","CTCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14459,"B2","CTAG2","CTAG2","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","Letetresgene Autoleucel","Letetresgene Autoleucel",null,"clin. trials",26193344,"CIVIC","Ng_et_al_2018_Supp_7_CNV_KHYG-1-1.csv","KHYG-1-1","Cell line","lymphoma","NKT","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14534,"B2","ERBB2","ERBB2","ampl.","ovarian","ampl. (GoF)","response","Trastuzumab","Trastuzumab","her2 inhibitor","early trials","20003286, 12525520","GDKD","Ng_et_al_2018_Supp_7_CNV_KHYG-1-1.csv","KHYG-1-1","Cell line","lymphoma","NKT","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14620,"B3","CDKN2A","CDKN2A","del.","cancer_unspecified","any variant (LoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Ng_et_al_2018_Supp_7_CNV_KHYG-1-1.csv","KHYG-1-1","Cell line","lymphoma","NKT","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14658,"B3","FGFR1","FGFR1","ampl.","head_neck","ampl. (GoF)","sensitivity","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","preclinical",23418312,"GDKD","Ng_et_al_2018_Supp_7_CNV_KHYG-1-1.csv","KHYG-1-1","Cell line","lymphoma","NKT","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14749,"B2","MET","MET","ampl.","colorectal","ampl. (GoF)","resistance","Anti-EGFR MAbs","Anti-EGFR MAbs","egfr inhibitor","early trials",23729478,"GDKD","Ng_et_al_2018_Supp_7_CNV_Ki-JK-1.csv","KIJK-1","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14777,"B3","CDKN2C","CDKN2C","del.","cancer_unspecified","any variant (LoF)","sensitivity","CDK2 Inhibitors","CDK2 Inhibitors","cdk2/4 inhibitor","preclinical","22471707, 22997239","GDKD","Ng_et_al_2018_Supp_7_CNV_Ki-JK-1.csv","KIJK-1","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14831,"B2","HDAC2","HDAC2","del.","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Ng_et_al_2018_Supp_7_CNV_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[14945,"B2","ERBB2","ERBB2","ampl.","bladder","ampl. (GoF)","response","Afatinib","Afatinib","her2 inhibitor","case report",27044931,"GDKD","Ng_et_al_2018_Supp_7_CNV_MTA-1.csv","MTA-1","Cell line","lymphoma","NKT","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15045,"B3","BRCA1","BRCA1","ampl.","Malignant Mesothelioma","ampl. (expr.)","sensitivity/response","Vinorelbine","Vinorelbine","alkaloid","preclinical",22190288,"CIVIC","Ng_et_al_2018_Supp_7_CNV_MTA-1.csv","MTA-1","Cell line","lymphoma","NKT","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15158,"B2","ERBB2","ERBB2","ampl.","gastric","ampl. (GoF)","response","Afatinib","Afatinib","egfr inhibitor","case report","AACR 2014 (abstr CT228)","GDKD","Ng_et_al_2018_Supp_7_CNV_My-La-1.csv","My-La-1","Cell line","lymphoma","CTCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15217,"B2","ERBB2","ERBB2","ampl.","gastric","ampl. (GoF)","response","Pertuzumab","Pertuzumab","her2 inhibitor","early trials",24960402,"GDKD","Ng_et_al_2018_Supp_7_CNV_My-La-1.csv","My-La-1","Cell line","lymphoma","CTCL","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15334,"B3","CBLC","CBLC","ampl.","Cancer","ampl. (expr.)","resistance","Olaparib","Olaparib","parp inhibitor","preclinical",25883215,"CIVIC","Ng_et_al_2018_Supp_7_CNV_NKL-1.csv","NKL-1","Cell line","lymphoma","NKT","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15364,"B3","SMARCA1","SMARCA1","del.","cancer_unspecified","any variant (LoF)","sensitivity","EZH2 Inhibitor In RAS Wt","EZH2 Inhibitor In RAS Wt","ezh2 inhibitor","preclinical",26552009,"GDKD","Ng_et_al_2018_Supp_7_CNV_NKL-1.csv","NKL-1","Cell line","lymphoma","NKT","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15457,"B3","RET","RET","ampl.","Breast Cancer","ampl. (overexpr.)","sensitivity/response","Vandetanib","Vandetanib","egfr inhibitor","preclinical",26686064,"CIVIC","Ng_et_al_2018_Supp_7_CNV_OCILY12-1.csv","OCI-Ly12-1","Cell line","lymphoma","NOS","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15521,"B3","LYN","LYN","ampl.","Chronic Myeloid Leukemia","ampl. (overexpr.)","resistance","Nilotinib","Nilotinib","bcr-abl inhibitor","preclinical",18191450,"CIVIC","Ng_et_al_2018_Supp_7_CNV_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15589,"B2","CDKN2A","CDKN2A","del.","Lung Non-small Cell Carcinoma","loss","resistance","Palbociclib","Palbociclib","cdk4/6 inhibitor","clin. trials",174591,"CIVIC","Ng_et_al_2018_Supp_7_CNV_SMZ-1-1.csv","SMZ-1-1","Cell line","lymphoma","NOS","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15702,"B2","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",27091708,"CIVIC","Ng_et_al_2018_Supp_7_CNV_SMZ-1-1.csv","SMZ-1-1","Cell line","lymphoma","NOS","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15731,"B3","CDKN2A","CDKN2A","del.","cancer_unspecified","any variant (LoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical",22471707,"GDKD","Ng_et_al_2018_Supp_7_CNV_SMZ-1-1.csv","SMZ-1-1","Cell line","lymphoma","NOS","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15851,"B2","MET","MET","ampl.","Cancer","ampl.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25232318,"CIVIC","Ng_et_al_2018_Supp_7_CNV_SR786.csv","SR786","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15880,"B2","NTRK1","NTRK1","ampl.","Solid Tumor","ampl.","sensitivity/response","Larotrectinib","Larotrectinib","trk inhibitor","case report",30624546,"CIVIC","Ng_et_al_2018_Supp_7_CNV_SR786.csv","SR786","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[15980,"B3","AURKA","AURKA","ampl.","Cervical Adenocarcinoma","ampl. (overexpr.)","resistance","Paclitaxel","Paclitaxel","alkaloid","preclinical",12559175,"CIVIC","Ng_et_al_2018_Supp_7_CNV_SUDHL1.csv","SUDHL1","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16033,"B2","EGFR","EGFR","ampl.","Lung Non-small Cell Carcinoma","ampl. (overexpr.), ampl.","sensitivity/response","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor","egfr inhibitor","clin. trials","22056021, 26439803, 20826716","CIVIC","Ng_et_al_2018_Supp_7_CNV_SUP-M2.csv","SUP-M2","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16099,"B3","MAGEH1","MAGEH1","ampl.","Bile Duct Adenocarcinoma","ampl. (expr.)","resistance","Gemcitabine","Gemcitabine","antimetabolite","preclinical",20088962,"CIVIC","Ng_et_al_2018_Supp_7_CNV_SUP-M2.csv","SUP-M2","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16167,"B2","RICTOR","RICTOR","ampl.","Lung Small Cell Carcinoma","ampl.","sensitivity/response","Vistusertib","Vistusertib","mtor inhibitor","case report",173496,"CIVIC","Ng_et_al_2018_Supp_7_CNV_SUPM2.csv","SUP-M2","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16211,"B3","MYC","MYC","ampl.","Multiple Myeloma","ampl. (overexpr.)","sensitivity/response","JQ-1","JQ-1","bet inhibitor","preclinical",21889194,"CIVIC","Ng_et_al_2018_Supp_7_CNV_SUPM2.csv","SUP-M2","Cell line","lymphoma","ALCL Alk+","CNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16332,"B2","MET","MET","ampl.","renal","ampl. (GoF)","response","MET Inhibitors","MET Inhibitors","met inhibitor","early trials","23213094, AACR 2016 (abstr CT2006)","GDKD","Schrader_CNAs_WES_CNV_T-PLL_TP005.csv","TP005","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16352,"B2","PTEN","PTEN","del.","Bladder Carcinoma","loss","resistance","Everolimus","Everolimus","mtor inhibitor","clin. trials",23989949,"CIVIC","Schrader_CNAs_WES_CNV_T-PLL_TP005.csv","TP005","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16448,"B3","PTEN","PTEN","del.","Melanoma","loss","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Schrader_CNAs_WES_CNV_T-PLL_TP005.csv","TP005","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16490,"B2","RICTOR","RICTOR","ampl.","lung","ampl. (GoF)","response","MTORC1/2 Inhibitors","MTORC1/2 Inhibitors","mtor inhibitor","case report",26370156,"GDKD","Schrader_CNAs_WES_CNV_T-PLL_TP007.csv","TP007","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16601,"B2","NF2","NF2","del.","mesothelioma","any variant (LoF)","response","FAK Inhibitors","FAK Inhibitors","fak inhibitor","early trials","ENA 2012 (abstr 610)","GDKD","Schrader_CNAs_WES_CNV_T-PLL_TP009.csv","TP009","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16673,"B2","FGFR1","FGFR1","ampl.","Adenosquamous Lung Carcinoma","ampl.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","case report",24302556,"CIVIC","Schrader_CNAs_WES_CNV_T-PLL_TP011.csv","TP011","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16735,"B2","FANCA","FANCA","del.","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Schrader_CNAs_WES_CNV_T-PLL_TP014.csv","TP014","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16797,"B3","PTEN","PTEN","del.","Her2-receptor Positive Breast Cancer","loss","resistance","Dactolisib","Dactolisib","mtor inhibitor","preclinical",19010894,"CIVIC","Schrader_CNAs_WES_CNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16875,"B3","SMARCA1","SMARCA1","del.","cancer_unspecified","any variant (LoF)","sensitivity","EZH2 Inhibitor In RAS Wt","EZH2 Inhibitor In RAS Wt","ezh2 inhibitor","preclinical",26552009,"GDKD","Schrader_CNAs_WES_CNV_T-PLL_TP016.csv","TP016","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16921,"B2","PTEN","PTEN","del.","Pancreatic Carcinoma","loss","sensitivity/response","Akt Inhibitor MK2206","Akt Inhibitor MK2206","pi3k/akt inhibitor","case report",22025163,"CIVIC","Schrader_CNAs_WES_CNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[16969,"B3","PTEN","PTEN","del.","Breast Cancer","loss","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",25409150,"CIVIC","Schrader_CNAs_WES_CNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","CNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[17052,"B3","CDKN2A","CDKN2A","del.","Skin Melanoma","loss","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",24495407,"CIVIC","Watatani_et_al_19_CNAs_targeted_CNV_PTCL_NOS_PTCL016.csv","PTCL016","Patient","lymphoma","NOS","CNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[17150,"B3","NOTCH1","NOTCH1","ampl.","Colorectal Cancer","ampl.","sensitivity/response","NOTCH1 Antibody (PF-06293622)","NOTCH1 Antibody","gamma secretase inhibitor","preclinical",26152787,"CIVIC","Watatani_et_al_19_CNAs_targeted_CNV_PTCL_NOS_PTCL062.csv","PTCL062","Patient","lymphoma","NOS","CNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[17208,"B3","CDKN2A","CDKN2A","del.","glioma","any variant (LoF)","sensitivity","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","preclinical","22586120, 22711607","GDKD","Watatani_et_al_19_CNAs_targeted_CNV_PTCL_NOS_PTCL073.csv","PTCL073","Patient","lymphoma","NOS","CNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[17278,"B3","ATM","ATM","del.","lymphoma","any variant (LoF)","sensitivity","DNA-PKc Inhibitors","DNA-PKc Inhibitors","dna-pk inhibitor","preclinical",23761041,"GDKD","Watatani_et_al_19_CNAs_targeted_CNV_PTCL_NOS_PTCL100.csv","PTCL100","Patient","lymphoma","NOS","CNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[17365,"B2","CDKN2A","CDKN2A","del.","melanoma","any variant (LoF)","response","CDK4/6 Inhibitors","CDK4/6 Inhibitors","cdk4/6 inhibitor","case report","ASCO 2013 (abstr 2500)","GDKD","Watatani_et_al_19_CNAs_WES_CNV_PTCL_NOS_PTCL008.csv","PTCL008","Patient","lymphoma","NOS","CNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[17387,"B3","CDKN2A","CDKN2A","del.","Ovarian Cancer","loss","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",21278246,"CIVIC","Watatani_et_al_19_CNAs_WES_CNV_PTCL_NOS_PTCL014.csv","PTCL014","Patient","lymphoma","NOS","CNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[17470,"B1","IDH2","IDH2","R172M","Acute Myeloid Leukemia","any mut.","sensitivity/response","Enasidenib","Enasidenib","idh2 inhibitor","approved",28588020,"CIVIC","Abate_et_al_17_RNAseq_SNV_AITL_tp43.csv","tp43","Patient","lymphoma","AITL","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic/Likely_pathogenic|_risk_factor",-1,"x"]
[17510,"B2","ATM","ATM","L546P","Prostate Cancer","S2289*, N2875H, any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Abate_et_al_17_RNAseq_SNV_AITL_tp48.csv","tp48","Patient","lymphoma","AITL","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[17580,"B2","TP53","TP53","R248Q","myelodisplastic_syndrome","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Abate_et_al_17_RNAseq_SNV_AITL_tp55.csv","tp55","Patient","lymphoma","AITL","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic",0,"x"]
[17640,"B3","TP53","TP53","I195T","Cancer","deleterious any mut.","resistance","Rebemadlin","Rebemadlin","mdm2/mdmx inhibitor","preclinical",17671205,"CIVIC","Abate_et_al_17_RNAseq_SNV_ALCL_bcn20.csv","bcn20","Patient","lymphoma","ALCL","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq",{"$nulls":5},"NONE","Pathogenic",0,"x"]
[17731,"B3","TP53","TP53","Y220C","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Abate_et_al_17_RNAseq_SNV_ALCL_gps4.csv","gps4","Patient","lymphoma","ALCL","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic","0.00003"]
[17812,"B3","TP53","TP53","A70G","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Abate_et_al_17_RNAseq_SNV_ALCL_gps9.csv","gps9","Patient","lymphoma","ALCL","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq",{"$nulls":5},"NONE","None",-1,"x"]
[17875,"B2","TP53","TP53","V272M","Stomach Carcinoma","R175H, R282L, R213P","sensitivity/response","EAP Protocol","EAP Protocol",null,"case report",14514923,"CIVIC","Abate_et_al_17_RNAseq_SNV_NKTCL_nk09.csv","nk09","Patient","lymphoma","NKT","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq",{"$nulls":5},"NONE","Pathogenic","0.00011"]
[18083,"B2","JAK1","JAK1","G1097D","melanoma","any variant (LoF)","resistance","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",27433843,"GDKD","Abate_et_al_17_RNAseq_SNV_PTCL_NOS_bcn29.csv","bcn29","Patient","lymphoma","NOS","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[18118,"B3","TP53","TP53","V218E","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Abate_et_al_17_RNAseq_SNV_PTCL_NOS_bcn29.csv","bcn29","Patient","lymphoma","NOS","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq",{"$nulls":5},"NONE","None",-1]
[18199,"B2","TP53","TP53","R213*","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Abate_et_al_17_RNAseq_SNV_PTCL_NOS_spF469.csv","spF469","Patient","lymphoma","NOS","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq",{"$nulls":5},"NONE","NONE",0,"x"]
[18250,"B3","TP53","TP53","R280K","Glioblastoma","M237I","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Abate_et_al_17_RNAseq_SNV_PTCL_NOS_spF623.csv","spF623","Patient","lymphoma","NOS","SNV","10.1073/pnas.1608839114","Abate_et_al_17","RNA seq","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Conflicting_interpretations_of_pathogenicity",-1]
[18275,"B2","KIT","KIT","L15V","Thymic Carcinoma","V560DEL","sensitivity/response","Imatinib","Imatinib","bcr-abl inhibitor","case report",15201427,"CIVIC","Crescenzo_et_al_15_WES+RNAseq_SNV_ALCL_Alk+_GPS-56-57.csv","GPS-56-57","Patient","lymphoma","ALCL Alk+","SNV","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","None",-1]
[18296,"B2","KIT","KIT","L15V","Systemic Mastocytosis","D816V","sensitivity/response","Midostaurin","Midostaurin","multi TKI","clin. trials",27355533,"CIVIC","Crescenzo_et_al_15_WES+RNAseq_SNV_ALCL_Alk+_GPS-56-57.csv","GPS-56-57","Patient","lymphoma","ALCL Alk+","SNV","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","None",-1]
[18345,"B2","TP53","TP53","C176F","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Crescenzo_et_al_15_WES+RNAseq_SNV_ALCL_Alk+_GPS-56-57.csv","GPS-56-57","Patient","lymphoma","ALCL Alk+","SNV","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES + RNA seq","{'FATHMM': 'CANCER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.95', 'Pipeline': 'deleterious'}","CANCER","Damaging","deleterious","-0.95","deleterious","Likely_pathogenic",-1,"x"]
[18649,"B3","JAK1","JAK1","G1097S","Hepatocellular Carcinoma","S703I","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical",26701727,"CIVIC","Crescenzo_et_al_15_WES+RNAseq_SNV_ALCL_Alk-_GPS-78-46.csv","GPS-78-46","Patient","lymphoma","ALCL Alk-","SNV","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","None",-1]
[18682,"B3","ARID1A","ARID1A","Y417*","cancer_unspecified","any variant (LoF)","sensitivity","ATR Inhibitors","ATR Inhibitors","atr inhibitor","preclinical",27958275,"GDKD","Crescenzo_et_al_15_WES_SNV_ALCL_Alk-_GPS-68-69.csv","GPS-68-69","Patient","lymphoma","ALCL Alk-","SNV","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[18747,"B2","DNMT3A","DNMT3A","R882C","Acute Myeloid Leukemia","any mut.","sensitivity/response","Decitabine","Decitabine","demethylating agent","clin. trials",22124213,"CIVIC","DepMap_Portal_OCI-AML3.csv","OCI-AML3","Cell line","lymphoma","AML","SNV","https://depmap.org/portal/cell_line/ACH-000336?tab=mutation","DepMap_Portal",null,"{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic","0.00005","x"]
[18785,"B2","NRAS","NRAS","Q61L","Melanoma","any mut.","sensitivity/response","Trametinib","Trametinib","mek inhibitor","clin. trials",22805292,"CIVIC","DepMap_Portal_OCI-AML3.csv","OCI-AML3","Cell line","lymphoma","AML","SNV","https://depmap.org/portal/cell_line/ACH-000336?tab=mutation","DepMap_Portal",null,"{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Pathogenic/Likely_pathogenic",-1,"x"]
[18932,"B2","ROS1","ROS1","V917F","lung_adeno","S1986Y, S1986F (GoF)","response","Lorlatinib","Lorlatinib","alk inhibitor","case report",27401242,"GDKD","Dobashi_et_al_16_targeted_SNV_NKTCL_12.csv",12,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","NONE",0]
[19085,"B3","TP53","TP53","Y104N","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Dobashi_et_al_16_targeted_SNV_NKTCL_12.csv",12,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[19177,"B3","SMO","SMO","T349A","Medulloblastoma","D473H","sensitivity/response","Patidegib","Patidegib","hedgehog inhibitor","preclinical",22550175,"CIVIC","Dobashi_et_al_16_targeted_SNV_NKTCL_14.csv",14,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[19253,"B2","BRCA2","BRCA2","Q3262R","Peritoneal Serous Carcinoma","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Dobashi_et_al_16_targeted_SNV_NKTCL_18.csv",18,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Uncertain_significance",-1,"x"]
[19278,"B3","BRCA2","BRCA2","Q3262R","Pancreatic Cancer","(LoF)","sensitivity/response","Mitomycin","Mitomycin","antimetabolite","preclinical",16243825,"CIVIC","Dobashi_et_al_16_targeted_SNV_NKTCL_18.csv",18,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Uncertain_significance",-1]
[19332,"B3","ALK","ALK","R606G","Neuroblastoma","F1174L, F1245C, R1275Q","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","preclinical",26554404,"CIVIC","Dobashi_et_al_16_targeted_SNV_NKTCL_22.csv",22,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1]
[19357,"B3","ROS1","ROS1","R1569W","lung_adeno","G2032R (GoF)","sensitivity","Cabozantinib","Cabozantinib","multi TKI","preclinical",25351743,"GDKD","Dobashi_et_al_16_targeted_SNV_NKTCL_23.csv",23,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","NONE",0]
[19466,"B2","TP53","TP53","D149E","Breast Cancer","R249","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","clin. trials",9569050,"CIVIC","Dobashi_et_al_16_targeted_SNV_NKTCL_4.csv",4,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[19604,"B1","BRCA2","BRCA2","Q1994K","Ovarian Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","approved",30345884,"CIVIC","Dobashi_et_al_16_targeted_SNV_NKTCL_8.csv",8,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[19665,"B2","TP53","TP53","R81X","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Dobashi_et_al_16_targeted_SNV_NKTCL_9.csv",9,"Patient","lymphoma","NKT","SNV","10.1002/gcc.22348","Dobashi_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[19688,"B2","CHEK2","CHEK2","R180H","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","AACR 2015 (abstr CT322), 26510020","GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_(TFH)_PTCL-TFH13.csv","PTCL-TFH13","Patient","lymphoma","NOS (TFH)","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.00003","x"]
[19778,"B3","MTOR","MTOR","L2427R","Clear Cell Renal Cell Carcinoma","E1799K","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical",24631838,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_(TFH)_PTCL-TFH2.csv","PTCL-TFH2","Patient","lymphoma","NOS (TFH)","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1]
[20688,"B2","TP53","TP53","V235D","Breast Cancer","R249","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","clin. trials",9569050,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS17.csv","PTCL-NOS17","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1]
[21131,"B2","TP53","TP53","V142L","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS17.csv","PTCL-NOS17","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[21869,"B3","TP53","TP53","V235V274L","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS17.csv","PTCL-NOS17","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[22247,"B3","PIK3CA","PIK3CA","P124S","Lung Adenocarcinoma","H1047R","sensitivity/response","Dactolisib","Dactolisib","mtor inhibitor","preclinical",19029981,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS18.csv","PTCL-NOS18","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[22358,"B2","TP53","TP53","E194fsE167fsE287fsE326fs","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS20.csv","PTCL-NOS20","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[22580,"B2","ATM","ATM","P260T","gastric","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","ENA 2014 (abstr 8LBA)","GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS23.csv","PTCL-NOS23","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Uncertain_significance",-1,"x"]
[22905,"B2","TP53","TP53","R136H","breast","any mut. (LoF)","resistance","CDK4/CDK6 Inhibitor Abemaciclib","CDK4/CDK6 Inhibitor Abemaciclib","cdk4/6 inhibitor","early trials",27217383,"GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS23.csv","PTCL-NOS23","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[23172,"B3","TP53","TP53","R16H","Cancer","deleterious any mut.","resistance","Rebemadlin","Rebemadlin","mdm2/mdmx inhibitor","preclinical",17671205,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS23.csv","PTCL-NOS23","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[23502,"B3","EZH2","EZH2","V582M","Skin Melanoma","Y646","sensitivity/response","GSK126","GSK126","ezh2 inhibitor","preclinical",26304929,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS28.csv","PTCL-NOS28","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[23564,"B3","MTOR","MTOR","R32W","Endometrial Adenocarcinoma","S2215Y","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical",24631838,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS28.csv","PTCL-NOS28","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[23720,"B2","MTOR","MTOR","P315L","bladder","E2014K (GoF), E2419K (GoF), N1421D (GoF)","response","Everolimus","Everolimus","mtor inhibitor","case report","24625776, ASCO 2015 (abstr 11010)","GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS39.csv","PTCL-NOS39","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[23746,"B2","PTPRD","PTPRD","P1132L","sarcoma","any mut. (GoF)","response","IGF-1R Antibodies","IGF-1R Antibodies","igf1r inhibitor","case report",23800680,"GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS39.csv","PTCL-NOS39","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[26408,"B2","TP53","TP53","Y197H","germ-cell tumor","any mut. (lof) (lof) (lof) (lof) (lof) (LoF)","resistance","Cisplatin","Cisplatin","platinum","early trials",27646943,"GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS39.csv","PTCL-NOS39","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[26431,"B2","TP53","TP53","Y104H","acute_myeloid_leukemia","any mut. (lof) (lof) (lof) (lof) (lof) (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS39.csv","PTCL-NOS39","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[26567,"B3","PTPRD","PTPRD","G1405R","Head And Neck Carcinoma","any mut.","sensitivity/response","JSI-124","JSI-124","jak inhibitor","preclinical",26267899,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS39.csv","PTCL-NOS39","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[27516,"B3","TP53","TP53","Y77H","head_neck","any variant (lof) (lof) (lof) (lof) (lof) (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS39.csv","PTCL-NOS39","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[27761,"B2","MTOR","MTOR","P862S","Bladder Cancer","E2014K, E2419K","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials","23551593, 24625776","OncoKB","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS41.csv","PTCL-NOS41","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[27835,"B2","DNMT3A","DNMT3A","R693H","Acute Myeloid Leukemia","R882","resistance","Daunorubicin","Daunorubicin","anthracyclin","clin. trials",22081665,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS66.csv","PTCL-NOS66","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}",null,"-","deleterious","-0.93","deleterious","NONE",0]
[27893,"B3","ATM","ATM","M1644I","Mantle Cell Lymphoma","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",20124459,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS66.csv","PTCL-NOS66","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","None",-1,"x"]
[28259,"B2","TP53","TP53","R43H","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS7.csv","PTCL-NOS7","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[28629,"B3","TP53","TP53","R43H","thymic_lymphoma","any variant (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Heavican_et_al_19_SNV_targeted_SNV_NOS_PTCL-NOS7.csv","PTCL-NOS7","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-09-872549","Heavican_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[28704,"B2","TP53","TP53","D281N","Sarcoma","deleterious any mut.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",26646755,"CIVIC","Jiang_et_al_15_targeted_SNV_NKTCL_E15.csv","E15","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted",{"$nulls":5},"NONE","Pathogenic",0,"x"]
[28748,"B3","TP53","TP53","V225-spliceV225-splice","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Jiang_et_al_15_targeted_SNV_NKTCL_E18.csv","E18","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[28823,"B3","TP53","TP53","C135F","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Jiang_et_al_15_targeted_SNV_NKTCL_E26.csv","E26","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[28942,"B3","TP53","TP53","R273H","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Jiang_et_al_15_targeted_SNV_NKTCL_E50.csv","E50","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '-0.12', 'Pipeline': 'deleterious'}","CANCER","Neutral","tolerated","-0.12","deleterious","Pathogenic","0.00006"]
[28994,"B3","TP53","TP53","R280T","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Jiang_et_al_15_targeted_SNV_NKTCL_E55.csv","E55","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted",{"$nulls":5},"NONE","Likely_pathogenic",-1,"x"]
[29117,"B3","ARID1A","ARID1A","N935S","cancer_unspecified","any mut. (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",26069190,"GDKD","Jiang_et_al_15_targeted_SNV_NKTCL_E71.csv","E71","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted",{"$nulls":5},"NONE","None","0.00013","x"]
[29220,"B3","NRAS","NRAS","G13V","Melanoma","any mut.","sensitivity/response","Binimetinib","Binimetinib","mek inhibitor","preclinical",24588908,"CIVIC","Jiang_et_al_15_targeted_SNV_NKTCL_L12.csv","L12","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic/Likely_pathogenic",-1,"x"]
[29290,"B2","TP53","TP53","R248Q","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Jiang_et_al_15_targeted_SNV_NKTCL_L18.csv","L18","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic",0,"x"]
[29315,"B3","ARID1A","ARID1A","Q1127*","Ovarian Clear Cell Carcinoma","(LoF), Q456*, P1175FS*5","sensitivity/response","Dasatinib","Dasatinib","bcr-abl inhibitor","preclinical",27364904,"CIVIC","Jiang_et_al_15_targeted_SNV_NKTCL_L19.csv","L19","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0]
[29400,"B3","ARID1A","ARID1A","W2048*","Ovarian Clear Cell Carcinoma","(LoF)","sensitivity/response","GSK126","GSK126","ezh2 inhibitor","preclinical",25686104,"CIVIC","Jiang_et_al_15_WES_SNV_NKTCL_L08.csv","L08","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[29502,"B3","TP53","TP53","Q136*","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Jiang_et_al_15_WES_SNV_NKTCL_L16.csv","L16","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[29556,"B3","TP53","TP53","R248Q","thymic_lymphoma","any variant (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Jiang_et_al_15_WES_SNV_NKTCL_L18.csv","L18","Patient","lymphoma","NKT","SNV","10.1038/ng.3358","Jiang_et_al_15","WES","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic",0,"x"]
[29650,"B2","TP53","TP53","V65G","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL001.csv","ATL001","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[29748,"B3","SETD2","SETD2","G121S","cancer_unspecified","any variant","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical","ENA 2014 (abstr 211)","GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL014.csv","ATL014","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","None",0,"x"]
[29781,"B3","TP53","TP53","V40fsV40fs","thymic_lymphoma","any variant (lof) (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL027.csv","ATL027","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[29842,"B2","TP53","TP53","E12fsE12fs","breast","any mut. (lof) (LoF)","resistance","CDK4/CDK6 Inhibitor Abemaciclib","CDK4/CDK6 Inhibitor Abemaciclib","cdk4/6 inhibitor","early trials",27217383,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL032.csv","ATL032","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[29936,"B2","TP53","TP53","41-48del41-48del","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL047.csv","ATL047","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[29994,"B3","TP53","TP53","R64*","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL052.csv","ATL052","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30126,"B2","TP53","TP53","Q4*","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL083.csv","ATL083","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30138,"B3","TP53","TP53","Q4*","Cancer","deleterious any mut.","resistance","Rebemadlin","Rebemadlin","mdm2/mdmx inhibitor","preclinical",17671205,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL083.csv","ATL083","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30320,"B2","TP53","TP53","D149N","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL108.csv","ATL108","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30388,"B3","TP53","TP53","D149N","thymic_lymphoma","any variant (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL108.csv","ATL108","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30508,"B3","GATA3","GATA3","frame-shift-del","breast","any variant (GoF)","sensitivity","Aromatase Inhhibitors","Aromatase Inhhibitors","anti-estrogen","preclinical",24758297,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL133.csv","ATL133","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30550,"B2","TP53","TP53","G113fs","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL134.csv","ATL134","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30737,"B2","TP53","TP53","R141C","Gastric Adenocarcinoma","any mut.","sensitivity/response","Chemotherapy","Chemotherapy",null,"clin. trials",24740294,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL166.csv","ATL166","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[30789,"B2","TP53","TP53","R49P","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL167.csv","ATL167","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30850,"B3","JAK3","JAK3","L857P","megakaryoblastic_leukemia","R657Q, I87T, Q501H","sensitivity","JAK Inhibitors","JAK Inhibitors","jak inhibitor","preclinical",18397343,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL173.csv","ATL173","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","None",-1]
[30940,"B3","TP53","TP53","S109fsS109fs","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL210.csv","ATL210","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[30989,"B2","TP53","TP53","M114V","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL219.csv","ATL219","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[31084,"B3","CDKN2A","CDKN2A","R80*","Dermatofibrosarcoma Protuberans","loss","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",25852058,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL235.csv","ATL235","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0]
[31176,"B3","GATA3","GATA3","frame-shift-del","breast","any variant (GoF)","sensitivity","Aromatase Inhhibitors","Aromatase Inhhibitors","anti-estrogen","preclinical",24758297,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL238.csv","ATL238","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[31325,"B3","JAK1","JAK1","S703I","acute_lymphocytic_leukemia","S646F (GoF)","sensitivity","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical",22955920,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL244.csv","ATL244","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Pathogenic",-1]
[31389,"B2","TP53","TP53","G134E","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL254.csv","ATL254","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[31456,"B2","JAK1","JAK1","S703I","melanoma","any variant (LoF)","resistance","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",27433843,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL263.csv","ATL263","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Pathogenic",-1,"x"]
[31518,"B2","TP53","TP53","V25delinsRV","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL273.csv","ATL273","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[31582,"B2","TP53","TP53","V142L","Breast Cancer","R249","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","clin. trials",9569050,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL280.csv","ATL280","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1]
[31712,"B2","TP53","TP53","G55Dframe-shift-del","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL289.csv","ATL289","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[31756,"B3","TP53","TP53","G55Dframe-shift-del","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL289.csv","ATL289","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[31880,"B2","TP53","TP53","Y102C","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL307.csv","ATL307","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[31952,"B3","TP53","TP53","V25G","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL311.csv","ATL311","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[32027,"B3","GATA3","GATA3","frame-shift-del","breast","any variant","sensitivity","Aromatase Inhhibitors","Aromatase Inhhibitors","anti-estrogen","preclinical",24758297,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL318.csv","ATL318","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[32115,"B2","IDH2","IDH2","R172K","acute_myeloid_leukemia","R140Q switch-of-function, R172K switch-of-function","response","IDH2 Inhibitor","IDH2 Inhibitor","idh2 inhibitor","early trials","AACR 2014 (abstr CT103)","GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL323.csv","ATL323","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic/Likely_pathogenic|_risk_factor",-1,"x"]
[32307,"B3","TP53","TP53","S7fs","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL328.csv","ATL328","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[32366,"B3","TP53","TP53","G134E","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL336.csv","ATL336","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[32409,"B3","TP53","TP53","S83R","Glioblastoma","M237I","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL340.csv","ATL340","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0]
[32519,"B3","TP53","TP53","Y104C","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL344.csv","ATL344","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0]
[32613,"B2","TP53","TP53","R141C","Breast Cancer","R249","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","clin. trials",9569050,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL354.csv","ATL354","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","None",-1]
[32768,"B3","TP53","TP53","E126*G67E","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL359.csv","ATL359","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[32858,"B2","TP53","TP53","R81*","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL382.csv","ATL382","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[32987,"B2","B2M","B2M","L60fsL60fs","melanoma","any variant (lof) (LoF)","resistance","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",27433843,"GDKD","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL402.csv","ATL402","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[33039,"B2","TP53","TP53","P20L","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Kataoka_et_al_15_targeted_NGS_SNV_ATLL_ATL418.csv","ATL418","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[33138,"B2","TP53","TP53","V65G","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL001.csv","ATL001","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[33170,"B3","FGFR2","FGFR2","W241C","Endometrial Cancer","any mut.","sensitivity/response","Ponatinib","Ponatinib","multi TKI","preclinical",26574622,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL002.csv","ATL002","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[33256,"B3","ERBB2","ERBB2","P197L","Breast Cancer","V773A, N857S","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","preclinical",22046346,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL012.csv","ATL012","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",0]
[33311,"B2","BRCA2","BRCA2","A2889T","Breast Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials",28792849,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL015.csv","ATL015","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1,"x"]
[33403,"B2","EGFR","EGFR","G339R","lung","K757R, E746G (GoF)","response","Erlotinib","Erlotinib","egfr inhibitor","case report",26773740,"GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL020.csv","ATL020","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1]
[33449,"B2","EGFR","EGFR","G339R","lung","L858R (GoF), L861Q (GoF), G719A (GoF), G719S (GoF), G719C (GoF), G719D (GoF), L747S (GoF), S768I (GoF), L861P (GoF), L861R (GoF), exon 19 p.729-761 (GoF)","response","Irreversible EGFR TKIs","Irreversible EGFR TKIs","egfr inhibitor","late trials",22753918,"GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL020.csv","ATL020","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1]
[33503,"B2","MTOR","MTOR","Q1554E","Thyroid Gland Carcinoma","F2108L","resistance","Everolimus","Everolimus","mtor inhibitor","case report",25295501,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL022.csv","ATL022","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1]
[33586,"B2","JAK1","JAK1","G1097A","melanoma","any variant (LoF)","resistance","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",27433843,"GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL031.csv","ATL031","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1,"x"]
[33640,"B2","ATM","ATM","V2441F","bladder","any variant (LoF)","response","Cisplatin","Cisplatin","platinum","early trials",26238431,"GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL032.csv","ATL032","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Uncertain_significance",-1,"x"]
[33744,"B2","KIT","KIT","R135H","Melanoma","S628N","sensitivity/response","Imatinib","Imatinib","bcr-abl inhibitor","case report",25317746,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL039.csv","ATL039","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance",0]
[33750,"B2","KIT","KIT","R135H","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","case report",27371698,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL039.csv","ATL039","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance",0,"x"]
[33781,"B2","KIT","KIT","R135H","gastrointestinal_stromal_tumor","exon 11 p.550-592 (GoF), exon 17 p.788-828, exon 18 p.829-860 (GoF)","response","Ponatinib","Ponatinib","multi TKI","early trials","25239608, ASCO 2015 (abstr 10535), ASCO 2015 (abstr 10517)","GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL039.csv","ATL039","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance",0]
[33838,"B3","KIT","KIT","R135H","acute_myeloid_leukemia","exon 8 p.416-422 (GoF)","sensitivity","Imatinib","Imatinib","bcr-abl inhibitor","preclinical",15618474,"GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL039.csv","ATL039","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance",0]
[33878,"B2","KIT","KIT","R49H","Thymic Carcinoma","V560DEL","sensitivity/response","Imatinib","Imatinib","pdgfr inhibitor","case report",15201427,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL043.csv","ATL043","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance","0.00005"]
[33901,"B2","KIT","KIT","R49H","Gastrointestinal Stromal Tumor","wildtype, exon 11 any mut., exon 9 any mut.","sensitivity/response","Regorafenib","Regorafenib","multi TKI","clin. trials","27371698, 23177515, 22614970","CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL043.csv","ATL043","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance","0.00005","x"]
[33991,"B3","U2AF1","U2AF1","N38I","Chronic Myelomonocytic Leukemia","oncogenic any mut.s","sensitivity/response","H3B-8800","H3B-8800",null,"preclinical",29457796,"OncoKB","Kataoka_et_al_15_WES_SNV_ATLL_ATL043.csv","ATL043","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1,"x"]
[34024,"B3","TP53","TP53","13-14del","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL046.csv","ATL046","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[34093,"B2","TP53","TP53","R64*","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL052.csv","ATL052","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[34113,"B3","TP53","TP53","R64*","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL052.csv","ATL052","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[34199,"B2","PDGFRA","PDGFRA","C13S","Gastrointestinal Stromal Tumor","V561D, Exon 18 any mut., any mut.","sensitivity/response","Imatinib","Imatinib","pdgfr inhibitor","case report","18955451, 14645423","CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL059.csv","ATL059","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1,"x"]
[34235,"B3","SMARCB1","SMARCB1","Q359*","Synovial Sarcoma","del. (underexpr.)","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","preclinical",27391784,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL060.csv","ATL060","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[34298,"B2","EGFR","EGFR","V802A","Lung Non-small Cell Carcinoma","any mut.","sensitivity/response","Afatinib","Afatinib","egfr inhibitor","clin. trials","27083334, 22452896","CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL065.csv","ATL065","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1,"x"]
[34413,"B2","TP53","TP53","Y88H","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL069.csv","ATL069","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[34446,"B2","PDGFRA","PDGFRA","M628I","Gastrointestinal Stromal Tumor","D842V","resistance","Sunitinib","Sunitinib","multi TKI","case report",18955458,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL071.csv","ATL071","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1]
[34491,"B2","MET","MET","H148Q","cancer_unspecified","exon 14 skipping (GoF)","response","Crizotinib","Crizotinib","met inhibitor","early trials","ASCO 2016 (abstr 108), ASCO 2017 (abstr 8511)","GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL074.csv","ATL074","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1]
[34524,"B2","TP53","TP53","H61R","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL074.csv","ATL074","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[34561,"B1","KIT","KIT","T847M","melanoma","exon 11 p.550-592, exon 13 p.627-664 (GoF)","response","Imatinib","Imatinib","pdgfr inhibitor","NCCN guidelines","NCCN","GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL077.csv","ATL077","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance",0]
[34597,"B2","KIT","KIT","T847M","Gastrointestinal Stromal Tumor","wildtype, exon 11 any mut., exon 9 any mut.","sensitivity/response","Regorafenib","Regorafenib","multi TKI","clin. trials","27371698, 23177515, 22614970","CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL077.csv","ATL077","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance",0,"x"]
[34667,"B3","KIT","KIT","T847M","gastrointestinal_stromal_tumor","V559I, H687Y, T670, V654A, A829P, D816, N822, Y823D (GoF)","resistance","Imatinib","Imatinib","bcr-abl inhibitor","preclinical","23582185, 21689725, 17259998","GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL077.csv","ATL077","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","Uncertain_significance",0]
[34715,"B2","TP53","TP53","Q4*","acute_myeloid_leukemia","wild type (LoF)","response","HDM2 Inhibitor","HDM2 Inhibitor","mdm2/mdmx inhibitor","early trials","AACR 2017 (abstr CT152)","GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL083.csv","ATL083","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[34754,"B2","KDR","KDR","E979D","Colorectal Adenocarcinoma","R961W","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",27004155,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL085.csv","ATL085","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1]
[34810,"B2","KIT","KIT","R177H","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","case report",27371698,"CIVIC","Kataoka_et_al_15_WES_SNV_ATLL_ATL090.csv","ATL090","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1,"x"]
[34824,"B2","KIT","KIT","R177H","Melanoma","D816, Exon 17 any mut.s, Oncogenic any mut.s, T670I, V654A","sensitivity/response","Imatinib","Imatinib","kit inhibitor","clin. trials","21642685, 23775962","OncoKB","Kataoka_et_al_15_WES_SNV_ATLL_ATL090.csv","ATL090","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1,"x"]
[34898,"B3","KIT","KIT","R177H","acute_myeloid_leukemia","exon 8 p.416-422 (GoF)","sensitivity","Imatinib","Imatinib","pdgfr inhibitor","preclinical",15618474,"GDKD","Kataoka_et_al_15_WES_SNV_ATLL_ATL090.csv","ATL090","Patient","lymphoma","ATLL","SNV","10.1038/ng.3415","Kataoka_et_al_15","WES",{"$nulls":5},"NONE","None",-1]
[34936,"B3","NF1","NF1","Q282R","malignant_peripheral_nerve_sheat_tumor, leukemia","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical","18483311, 20505189, 24509877","GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-10.csv","PLL-10","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance",0,"x"]
[35062,"B3","ZRSR2","ZRSR2","C299R","Chronic Myelomonocytic Leukemia","oncogenic any mut.s","sensitivity/response","H3B-8800","H3B-8800",null,"preclinical",29457796,"OncoKB","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-12.csv","PLL-12","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': '-', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}","-","-","deleterious","-0.93","deleterious","None",-1,"x"]
[35103,"B3","ATM","ATM","I2899M","Mantle Cell Lymphoma","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",20124459,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-14.csv","PLL-14","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Uncertain_significance",-1,"x"]
[35186,"B3","LRP1B","LRP1B","A1444T","Ovarian Cancer","exon 12-22 del.","resistance","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22896685,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-16.csv","PLL-16","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None","0.00003"]
[35242,"B3","ATM","ATM",-574,"Mantle Cell Lymphoma","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",20124459,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-19.csv","PLL-19","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[35290,"B2","MTOR","MTOR","V1885I","Renal Cell Carcinoma","Q2223K","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",24622468,"OncoKB","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-1.csv","PLL-1","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","Conflicting_interpretations_of_pathogenicity","0.00055"]
[35472,"B2","PDGFRA","PDGFRA","L221F","Gastrointestinal Stromal Tumor","D842V","resistance","Imatinib","Imatinib","bcr-abl inhibitor","case report",14645423,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-21.csv","PLL-21","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES",{"$nulls":5},"NONE","Benign/Likely_benign","0.00456"]
[35481,"B2","TSC2","TSC2","G676A","gastric","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","case report",26859683,"GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-21.csv","PLL-21","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Likely_benign","0.0057","x"]
[35582,"B3","ATM","ATM","L2427P","lymphoma","any variant (LoF)","sensitivity","DNA-PKc Inhibitors","DNA-PKc Inhibitors","dna-pk inhibitor","preclinical",23761041,"GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-23.csv","PLL-23","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance",-1,"x"]
[35632,"B2","ATM","ATM","L694R","bladder","any variant (LoF)","response","Cisplatin","Cisplatin","platinum","early trials",26238431,"GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-25.csv","PLL-25","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[35734,"B3","ATM","ATM","D2016G","glioma","any variant (LoF)","sensitivity","Temozolomide","Temozolomide","alkylating agent","preclinical",23960094,"GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-29.csv","PLL-29","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic/Likely_pathogenic",-1,"x"]
[35786,"B2","HLA-C","HLA-C","E299K","Colorectal Cancer","copy-neutral loss of heterozygosity","resistance","Therapeutic Tumor Infiltrating Lymphocytes","Therapeutic Tumor Infiltrating Lymphocytes",null,"case report",27959684,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-2.csv","PLL-2","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES",{"$nulls":5},"NONE","None","0.09089"]
[35885,"B3","ZRSR2","ZRSR2","C299R","Myelodysplastic Syndromes","oncogenic any mut.s","sensitivity/response","H3B-8800","H3B-8800",null,"preclinical",29457796,"OncoKB","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-2.csv","PLL-2","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': '-', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}","-","-","deleterious","-0.93","deleterious","None",-1,"x"]
[35944,"B3","ABL1","ABL1","G706S","Lung Non-small Cell Carcinoma","R351W","sensitivity/response","Imatinib","Imatinib","pdgfr inhibitor","preclinical",26758680,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-31.csv","PLL-31","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Benign","0.00262"]
[35974,"B3","NF1","NF1","V185M","malignant_peripheral_nerve_sheat_tumor, leukemia","any variant (LoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",23221341,"GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-31.csv","PLL-31","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1,"x"]
[36052,"B2","ERBB2","ERBB2","A356D","Lung Adenocarcinoma","Kinase Domain any mut., Y772-A775DUP, G776L, G778-P780DUP","sensitivity/response","Afatinib","Afatinib","her2 inhibitor","case report","22325357, 26559459","CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-34.csv","PLL-34","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","None",-1,"x"]
[36084,"B3","ERBB2","ERBB2","A356D","Stomach Carcinoma","T862A","sensitivity/response","Lapatinib","Lapatinib","her2 inhibitor","preclinical",22046346,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-34.csv","PLL-34","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","None",-1]
[36189,"B3","CDKN2C","CDKN2C",-46,"cancer_unspecified","any variant (lof) (LoF)","sensitivity","CDK2 Inhibitors","CDK2 Inhibitors","cdk2/4 inhibitor","preclinical","22471707, 22997239","GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-36.csv","PLL-36","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[36294,"B3","ATM","ATM","G2891R","Mantle Cell Lymphoma","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",20124459,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-3.csv","PLL-3","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[36528,"B3","EZH2","EZH2","L110R","Skin Melanoma","Y646","sensitivity/response","GSK126","GSK126","ezh2 inhibitor","preclinical",26304929,"CIVIC","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-40.csv","PLL-40","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}",null,"-","deleterious","-0.93","deleterious","None",-1]
[36558,"B2","ATM","ATM","L2427R","colorectal","any variant (LoF)","response","ATR Inhibitors","ATR Inhibitors","atr inhibitor","case report","ENA 2015 (abstract A48)","GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-5.csv","PLL-5","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance",-1,"x"]
[36624,"R1(OncoKB)","ALK","ALK","V597L","Non-Small Cell Lung Cancer","G1202R, I1171N","resistance","Alectinib","Alectinib","alk inhibitor","unspecified","24736079, 27130468, 27432227, 29373100, 29376144, 29650534, 23239810, 25393796, 25393798, 25736571, 27565911, 29376144, 29650534","OncoKB","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-5.csv","PLL-5","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES",{"$nulls":5},"NONE","None",-1]
[36653,"B2","ATM","ATM","V2727G","gastric","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","ENA 2014 (abstr 8LBA)","GDKD","Kiel_et_al_14_SNV_WES_SNV_T-PLL_PLL-8.csv","PLL-8","Patient","lymphoma","T-PLL","SNV","10.1182/blood-2014-03-559542","Kiel_et_al_14","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance",-1,"x"]
[36735,"B2","TP53","TP53","R273C","Stomach Carcinoma","R175H, R282L, R213P","sensitivity/response","EAP Protocol","EAP Protocol",null,"case report",14514923,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_11.csv",11,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic/Likely_pathogenic",0]
[36784,"B3","ATM","ATM","S49C","Mantle Cell Lymphoma","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",20124459,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_12.csv",12,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Benign","0.00847","x"]
[36871,"B2","IDH1","IDH1","M18I","High Grade Glioma","R132","sensitivity/response","Bevacizumab","Bevacizumab","vegf inhibitor","clin. trials",22199315,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_24.csv",24,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[36915,"B3","NOTCH1","NOTCH1","A1387V","Head And Neck Squamous Cell Carcinoma","(LoF)","sensitivity/response","Porcupine Inhibitor WNT974","Porcupine Inhibitor WNT974","wnt inhibitor","preclinical",24277854,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_28.csv",28,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[36969,"B3","TP53","TP53","S17fs","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_34.csv",34,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[37071,"B2","BRAF","BRAF","R726H","Gastrointestinal Stromal Tumor","exon 15 any mut.","resistance","Regorafenib","Regorafenib","multi TKI","case report",22614970,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_37.csv",37,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0,"x"]
[37168,"B2","BRAF","BRAF","R726H","Melanoma","L505H","resistance","Vemurafenib","Vemurafenib","raf inhibitor","clin. trials",25515853,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_37.csv",37,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[37297,"B2","ATM","ATM","I1294T","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_39.csv",39,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[37327,"B3","ATM","ATM","L1956H","lymphoma","any variant (LoF)","sensitivity","DNA-PKc Inhibitors","DNA-PKc Inhibitors","dna-pk inhibitor","preclinical",23761041,"GDKD","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_40.csv",40,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Uncertain_significance",-1,"x"]
[37391,"B3","IDH1","IDH1","G97D","High Grade Glioma","R132C","sensitivity/response","AGI-5198","AGI-5198","idh1 inhibitor","preclinical",23558169,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_44.csv",44,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[37476,"B2","BRAF","BRAF","G759R","Melanoma","V600","resistance","Refametinib","Refametinib","mek inhibitor","case report",23434733,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_47.csv",47,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[37550,"B2","BRAF","BRAF","G759R","Colorectal Cancer","V600","resistance","Panitumumab","Panitumumab","egfr inhibitor","clin. trials",23325582,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_47.csv",47,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[37744,"B3","FAT1","FAT1","G3909R","head_neck","any mut. (LoF)","sensitivity","BET Inhibitors","BET Inhibitors","bet inhibitor","preclinical",27397505,"GDKD","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_64.csv",64,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[37750,"B3","NOTCH1","NOTCH1","G766C","Head And Neck Squamous Cell Carcinoma","(LoF)","sensitivity/response","Porcupine Inhibitor WNT974","Porcupine Inhibitor WNT974","wnt inhibitor","preclinical",24277854,"CIVIC","Laginestra_et_al_19_targeted_SNV_NOS_PTCL_NOS_66.csv",66,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[37882,"B3","CDK12","CDK12","P1266L","Ovarian Serous Carcinoma","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",24240700,"CIVIC","Laginestra_et_al_19_WES_SNV_NOS_PTCL-NOS_21.csv",21,"Patient","lymphoma","NOS","SNV","10.1038/s41379-019-0279-8","Laginestra_et_al_19","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[38490,"B2","TP53","TP53","Y234Q","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Lobello_et_al_21_SNV_ALK+1_ALK+1R.csv","ALK+1_ALK+1R","Patient","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[38614,"B2","BRAF","BRAF","A404fs","Gastrointestinal Stromal Tumor","exon 15 any mut.","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",27371698,"CIVIC","Lobello_et_al_21_SNV_ALK-11.csv","ALK-11","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[38639,"B3","ARID1A","ARID1A","G285fsG285fs","cancer_unspecified","any variant (lof) (LoF)","sensitivity","ATR Inhibitors","ATR Inhibitors","atr inhibitor","preclinical",27958275,"GDKD","Lobello_et_al_21_SNV_ALK-11.csv","ALK-11","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[38750,"B2","TP53","TP53","C176F","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Lobello_et_al_21_SNV_ALK-1.csv","ALK-1","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing","{'FATHMM': 'CANCER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.95', 'Pipeline': 'deleterious'}","CANCER","Damaging","deleterious","-0.95","deleterious","Likely_pathogenic",-1,"x"]
[38811,"B2","ALK","ALK","S252F","Neuroblastoma","F1245C","resistance","Crizotinib","Crizotinib","alk inhibitor","case report",23598171,"CIVIC","Lobello_et_al_21_SNV_ALK-22.csv","ALK-22","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","Uncertain_significance",-1]
[38816,"B2","ALK","ALK","S252F","lung_adeno","L1196M (GoF), L1152R (GoF), C1156Y (GoF), F1174L (GoF), G1202R (GoF), S1206Y (GoF), G1269A (GoF)","resistance","Crizotinib","Crizotinib","alk inhibitor","case report",22277784,"GDKD","Lobello_et_al_21_SNV_ALK-22.csv","ALK-22","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","Uncertain_significance",-1]
[38876,"B2","ALK","ALK","R551Q","lung_adeno","L1198F (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",26698910,"GDKD","Lobello_et_al_21_SNV_ALK-5.csv","ALK-5","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","Uncertain_significance","0.00005"]
[38887,"B3","ALK","ALK","R551Q","Neuroblastoma","F1174L, F1245C, R1275Q","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","preclinical",26554404,"CIVIC","Lobello_et_al_21_SNV_ALK-5.csv","ALK-5","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","Uncertain_significance","0.00005"]
[38958,"B2","TP53","TP53","H214fs","Breast Cancer","any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","case report",10786679,"CIVIC","Lobello_et_al_21_SNV_ALK-9.csv","ALK-9","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[38996,"B3","TP53","TP53","H214fsH214fs","thymic_lymphoma","any variant (lof) (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Lobello_et_al_21_SNV_ALK-9.csv","ALK-9","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[39136,"B2","TP53","TP53","R248Q","Stomach Carcinoma","R175H, R282L, R213P","sensitivity/response","EAP Protocol","EAP Protocol",null,"case report",14514923,"CIVIC","Lobello_et_al_21_SNV_CA3.csv","CA3","Patient","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic",0]
[39236,"B2","FBXW7","FBXW7","R367*","Cancer","any mut.","sensitivity/response","MTOR Inhibitor","MTOR Inhibitor","mtor inhibitor","clin. trials",24586741,"CIVIC","Lobello_et_al_21_SNV_CA4.csv","CA4","Patient","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[39308,"B2","TP53","TP53","R273C","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Lobello_et_al_21_SNV_CA7.csv","CA7","Patient","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic/Likely_pathogenic",0,"x"]
[39354,"B2","TP53","TP53","S215C","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Lobello_et_al_21_SNV_DEL.csv","DEL","Cell Line","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","None",-1,"x"]
[39399,"B3","JAK1","JAK1","G1097V","Hepatocellular Carcinoma","S703I","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical",26701727,"CIVIC","Lobello_et_al_21_SNV_FE-PD.csv","FE-PD","Cell Line","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[39478,"B2","KIT","KIT","I857S","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","case report",27371698,"CIVIC","Lobello_et_al_21_SNV_HK-10R.csv","HK-10R","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","None",-1,"x"]
[39511,"B2","KIT","KIT","I857S","gastrointestinal_stromal_tumor","exon 14 p.664-714 (GoF), exon 13 p.627-664 (GoF)","decreased sensitivity","Imatinib","Imatinib","kit inhibitor","late trials",18955458,"GDKD","Lobello_et_al_21_SNV_HK-10R.csv","HK-10R","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","None",-1]
[39559,"B2","POLE","POLE","frame-shift-delframe-shift-del","colorectal","any variant (lof) (LoF)","response","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",28188185,"GDKD","Lobello_et_al_21_SNV_HK-10R.csv","HK-10R","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[39666,"B2","JAK2","JAK2","L1078S","Polycythemia Vera","V617F","sensitivity/response","Peginterferon Alfa-2b","Peginterferon Alfa-2b","interferon","clin. trials",16709929,"CIVIC","Lobello_et_al_21_SNV_HK-10.csv","HK-10","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","None",-1]
[39705,"B2","MET","MET","H748R","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Lobello_et_al_21_SNV_HK-3.csv","HK-3","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","None",-1,"x"]
[39734,"B3","MET","MET","H748R","cancer_unspecified","Y1230C (GoF), Y1235D (GoF)","reduced sensitivity","Crizotinib","Crizotinib","met inhibitor","preclinical",17483355,"GDKD","Lobello_et_al_21_SNV_HK-3.csv","HK-3","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","None",-1]
[39805,"B2","JAK1","JAK1","G1097D","colorectal","any variant (LoF)","resistance","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",27903500,"GDKD","Lobello_et_al_21_SNV_HK-5.csv","HK-5","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[39922,"B2","BRAF","BRAF","D594N","Gastrointestinal Stromal Tumor","exon 15 any mut.","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",27371698,"CIVIC","Lobello_et_al_21_SNV_HK-7.csv","HK-7","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","Likely_pathogenic",0,"x"]
[40132,"B3","BRAF","BRAF","D594N","Solid Tumor","G466V","sensitivity/response","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",28783719,"CIVIC","Lobello_et_al_21_SNV_HK-7.csv","HK-7","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","Likely_pathogenic",0]
[40167,"B2","IDH1","IDH1","R132C","Acute Myeloid Leukemia","any mut.","sensitivity/response","Venetoclax","Venetoclax","bcl2 inhibitor","case report",30725494,"CIVIC","Lobello_et_al_21_SNV_HK-9.csv","HK-9","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","Pathogenic/Likely_pathogenic",0,"x"]
[40285,"B3","MTOR","MTOR","D608Y","Breast Cancer","F2108L, A2034V","resistance","Sirolimus","Sirolimus","mtor inhibitor","preclinical",27279227,"CIVIC","Lobello_et_al_21_SNV_KARPAS-299.csv","KARPAS-299","Cell Line","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","None",-1]
[40295,"B3","TP53","TP53","R273C","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Lobello_et_al_21_SNV_KARPAS-299.csv","KARPAS-299","Cell Line","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic/Likely_pathogenic",0,"x"]
[40433,"B3","TP53","TP53","R273H","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Lobello_et_al_21_SNV_SU-DHL-1.csv","SU-DHL-1","Cell Line","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '-0.12', 'Pipeline': 'deleterious'}","CANCER","Neutral","tolerated","-0.12","deleterious","Pathogenic","0.00006"]
[40508,"B2","SMARCA4","SMARCA4","P197S","ovarian_rhabdoid_tumor","any variant (LoF)","response","EZH2 Inhibitor","EZH2 Inhibitor","ezh2 inhibitor","case report","ESMO 2015 (abstract 302)","GDKD","Lobello_et_al_21_SNV_V15.csv","V15","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","Benign","0.00163","x"]
[40587,"B2","BRCA2","BRCA2","L771*","melanoma","any variant (LoF)","response","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",26997480,"GDKD","Lobello_et_al_21_SNV_V9.csv","V9","Patient","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[40650,"B3","STAG2","STAG2","R440*","glioma","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",24356817,"GDKD","Lobello_et_al_21_SNV_V9.csv","V9","Patient","lymphoma","ALCL Alk+","SNV","10.1038/s41375-020-01093-1","Lobell_et_al_21","targeted Sequencing",{"$nulls":5},"NONE","NONE",0,"x"]
[40729,"B2","BRAF","BRAF","P341A","Melanoma","V600D","sensitivity/response","BRAF Inhibitor","BRAF Inhibitor","raf inhibitor","case report",31580757,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_003.csv",3,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[40882,"B2","BRAF","BRAF","P341A","thyroid","V600E (GoF)","response","MEK-inhibitor Enhanced Radioiodine Uptake","MEK-inhibitor Enhanced Radioiodine Uptake",null,"early trials",23406027,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_003.csv",3,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[40966,"B3","BRAF","BRAF","P341A","Skin Melanoma","D594G, G469E","sensitivity/response","Sorafenib","Sorafenib","multi TKI","preclinical",18794803,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_003.csv",3,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[41548,"B2","TP53","TP53","V134L","myelodisplastic_syndrome","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_004.csv",4,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[41766,"B3","TP53","TP53","V173L","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_004.csv",4,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","None",-1,"x"]
[41829,"B3","TP53","TP53","V134L","thymic_lymphoma","any variant (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_004.csv",4,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[42140,"B2","TP53","TP53","G22V","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_007.csv",7,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","None",-1,"x"]
[42285,"B3","TP53","TP53","G115V","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_007.csv",7,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[42615,"B2","EZH2","EZH2","V582E","Follicular Lymphoma","activating any mut.","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","clin. trials",33035457,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_013.csv",13,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[42691,"B3","SETD2","SETD2","frame-shift-delframe-shift-delM1783R","cancer_unspecified","any variant (lof) (lof) (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical","ENA 2014 (abstr 211)","GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_013.csv",13,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[42844,"B3","KRAS","KRAS","A59G","Colorectal Cancer","G13D","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","preclinical",20978259,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_015.csv",15,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[43059,"B2","DNMT3A","DNMT3A","V31F","Acute Myeloid Leukemia","R882","sensitivity/response","Idarubicin","Idarubicin","anthracyclin","clin. trials",22081665,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_018.csv",18,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0]
[43154,"B2","BRCA2","BRCA2","A938E","pancreatic","any variant (LoF)","response","Platinum","Platinum","platinum","case report",25719666,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_021.csv",21,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Conflicting_interpretations_of_pathogenicity","0.00014","x"]
[43223,"B2","MET","MET","H1192R","Lung Adenocarcinoma","exon 14 skipping any mut.","sensitivity/response","Capmatinib","Capmatinib","met inhibitor","case report",25971938,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_021.csv",21,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","None",-1,"x"]
[43280,"B2","MET","MET","H1192R","Non-Small Cell Lung Cancer","ampl., D1010H, D1010N, D1010Y, Exon 14 del., Exon 14 splice any mut., Y1003C, Y1003F, Y1003N","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials","21623265, 25971939, 26729443","OncoKB","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_021.csv",21,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","None",-1,"x"]
[43605,"B2","TP53","TP53","V14L","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_022.csv",22,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","None",-1,"x"]
[43961,"B3","TP53","TP53","V173L","Cancer","deleterious any mut.","resistance","Rebemadlin","Rebemadlin","mdm2/mdmx inhibitor","preclinical",17671205,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_022.csv",22,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","None",-1,"x"]
[44114,"B2","BRCA2","BRCA2","S976T","Ovarian Cancer","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_023.csv",23,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","Benign/Likely_benign","0.00076","x"]
[44210,"B2","BRCA2","BRCA2","S976T","breast","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","early trials",25847936,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_023.csv",23,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","Benign/Likely_benign","0.00076","x"]
[44326,"B2","IDH2","IDH2","R131C","Acute Myeloid Leukemia","any mut.","sensitivity/response","Venetoclax","Venetoclax","bcl2 inhibitor","case report",30725494,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_025.csv",25,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[44376,"B3","IDH2","IDH2","R209C","biliary_tract","R172 (GoF)","sensitivity","Dasatinib","Dasatinib","bcr-abl inhibitor","preclinical",27231123,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_025.csv",25,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0]
[45297,"B2","TP53","TP53","V233L","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_026.csv",26,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","None",-1,"x"]
[45682,"B2","TP53","TP53","V272L","breast","any mut. (LoF)","resistance","CDK4/CDK6 Inhibitor Abemaciclib","CDK4/CDK6 Inhibitor Abemaciclib","cdk4/6 inhibitor","early trials",27217383,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_026.csv",26,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","Likely_pathogenic",-1,"x"]
[46701,"B3","TP53","TP53","R123W","Cancer","deleterious any mut.","resistance","Rebemadlin","Rebemadlin","mdm2/mdmx inhibitor","preclinical",17671205,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_026.csv",26,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[47118,"B2","TP53","TP53","R174Q","Stomach Carcinoma","R175H, R282L, R213P","sensitivity/response","EAP Protocol","EAP Protocol",null,"case report",14514923,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_027.csv",27,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0]
[47615,"B3","TP53","TP53","R213Q","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_027.csv",27,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","Pathogenic",0,"x"]
[47677,"B3","TP53","TP53","R54Q","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_027.csv",27,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[48128,"B2","KDR","KDR","V15A","Colorectal Adenocarcinoma","R961W","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",27004155,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_045.csv",45,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","None",-1]
[48157,"B3","EZH2","EZH2","D620E","Skin Melanoma","Y646","sensitivity/response","GSK126","GSK126","ezh2 inhibitor","preclinical",26304929,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_045.csv",45,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0]
[48303,"B2","KRAS","KRAS","G12R","Colorectal Cancer","exon 2 any mut.","sensitivity/response","Regorafenib","Regorafenib","multi TKI","clin. trials",24559322,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_047.csv",47,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic",-1,"x"]
[48445,"B2","BRCA2","BRCA2","A938E","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_049.csv",49,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Conflicting_interpretations_of_pathogenicity","0.00014","x"]
[48502,"B3","BRCA2","BRCA2","N255H","Pancreatic Cancer","(LoF)","sensitivity/response","Mitomycin","Mitomycin","antimetabolite","preclinical",16243825,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_050.csv",50,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance",-1]
[48687,"B2","BRAF","BRAF","G469R","Colorectal Cancer","V600E","sensitivity/response","Vemurafenib","Vemurafenib","raf inhibitor","clin. trials",26460303,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_051.csv",51,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic/Likely_pathogenic",-1]
[48736,"B2","BRCA2","BRCA2","frame-shift-del","Ovarian Cancer","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_051.csv",51,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[49222,"B3","BRAF","BRAF","G469R","Melanoma","V600D","sensitivity/response","Vemurafenib","Vemurafenib","raf inhibitor","preclinical","18287029, 20551065","CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_051.csv",51,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic/Likely_pathogenic",-1]
[49335,"B3","TP53","TP53","R243W","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_051.csv",51,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0]
[49538,"B2","KRAS","KRAS","G13C","Colorectal Cancer","G13D","sensitivity/response","Cetuximab","Cetuximab","egfr inhibitor","clin. trials",20978259,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_055.csv",55,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic",-1]
[49688,"B2","POLE","POLE","S1892N","colorectal","any variant (LoF)","response","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",28188185,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_062.csv",62,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1,"x"]
[49965,"B2","TP53","TP53","R203L","Sarcoma","deleterious any mut.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",26646755,"CIVIC","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_063.csv",63,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[50350,"B3","TP53","TP53","R176L","thymic_lymphoma","any variant (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","McKinney_et_al_17_WES_SNV_HSTLCL_HSTL_063.csv",63,"Patient","lymphoma","HS-TCL","SNV","10.1158/2159-8290.CD-16-0330","McKinney_et_al_17","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[50604,"B2","JAK1","JAK1","R454W","melanoma","any variant (LoF)","resistance","PD1 Blockade","PD1 Blockade","pd1/pdl1 antibody","case report",27433843,"GDKD","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_009.csv",9,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[50855,"B2","TP53","TP53","P113L","Sarcoma","deleterious any mut.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",26646755,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_017.csv",17,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq",{"$nulls":5},"NONE","None",-1,"x"]
[50999,"B3","TP53","TP53","P152L","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_017.csv",17,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic",0,"x"]
[51369,"B2","TP53","TP53","R209W","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_024.csv",24,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq",{"$nulls":5},"NONE","NONE",0,"x"]
[51640,"B3","TP53","TP53","R89W","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_024.csv",24,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq",{"$nulls":5},"NONE","NONE",0,"x"]
[51783,"B3","TP53","TP53","frame-shift-delframe-shift-del","Cancer","deleterious any mut.","resistance","Rebemadlin","Rebemadlin","mdm2/mdmx inhibitor","preclinical",17671205,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_033.csv",33,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq",{"$nulls":5},"NONE","NONE",0,"x"]
[52176,"B2","TP53","TP53","V14L","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_035.csv",35,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq",{"$nulls":5},"NONE","None",-1,"x"]
[52354,"B3","TP53","TP53","V14L","Vulva Squamous Cell Carcinoma","R158H","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_035.csv",35,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq",{"$nulls":5},"NONE","None",-1]
[52764,"B3","TP53","TP53","C141Y","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_039.csv",39,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq",{"$nulls":5},"NONE","Pathogenic",-1,"x"]
[52864,"B2","NRAS","NRAS","A146T","Melanoma","Q61L, Q61R","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","case report",21576590,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_061.csv",61,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[52993,"B2","KRAS","KRAS","G12D","Lung Non-small Cell Carcinoma","any mut.","resistance","MEK Inhibitor RO4987655","MEK Inhibitor RO4987655","mek inhibitor","clin. trials",24947927,"CIVIC","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_066.csv",66,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic","0.00001","x"]
[53073,"B3","KRAS","KRAS","G12D","endometrial","any variant (GoF)","resistance","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",22662154,"GDKD","Moffitt_et_al_17_WES+RNAseq_SNV_EATL_EATL_066.csv",66,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic","0.00001","x"]
[53194,"B2","KRAS","KRAS","G12D","Colorectal Cancer","Q61H","resistance","Cetuximab","Cetuximab","egfr inhibitor","case report",22722830,"CIVIC","Moffit_et_al_17_WES_SNV_EATL_EATL_002.csv",2,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic","0.00001"]
[53293,"B3","JAK3","JAK3","M511I","lymphoma","A572V (GoF), A573V (GoF)","sensitivity","JAK Inhibitors","JAK Inhibitors","jak inhibitor","preclinical",22705984,"GDKD","Moffit_et_al_17_WES_SNV_EATL_EATL_002.csv",2,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[53466,"B2","KRAS","KRAS","G13D","Colorectal Cancer","exon 2 any mut.","sensitivity/response","Regorafenib","Regorafenib","multi TKI","clin. trials",24559322,"CIVIC","Moffit_et_al_17_WES_SNV_EATL_EATL_019.csv",19,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0,"x"]
[53720,"B2","TP53","TP53","G245C","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Moffit_et_al_17_WES_SNV_EATL_EATL_019.csv",19,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES",{"$nulls":5},"NONE","Pathogenic",-1,"x"]
[53972,"B3","KRAS","KRAS","G13D","Cancer","any mut.","sensitivity/response","Trametinib","Trametinib","mek inhibitor","preclinical",22169769,"CIVIC","Moffit_et_al_17_WES_SNV_EATL_EATL_019.csv",19,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0,"x"]
[54114,"B3","TP53","TP53","G113C","Glioblastoma","M237I","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Moffit_et_al_17_WES_SNV_EATL_EATL_019.csv",19,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES",{"$nulls":5},"NONE","Uncertain_significance",-1]
[54636,"B2","TP53","TP53","R136H","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Moffit_et_al_17_WES_SNV_EATL_EATL_036.csv",36,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[54814,"B3","TP53","TP53","R175H","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Moffit_et_al_17_WES_SNV_EATL_EATL_036.csv",36,"Patient","lymphoma","EATL","SNV","10.1084/jem.20160894","Moffitt_et_al_17","WES",{"$nulls":5},"NONE","Pathogenic","0.00003","x"]
[54971,"B1","KRAS","KRAS","A146T","lung","any variant (GoF)","resistance","EGFR TKIs","EGFR TKIs","egfr inhibitor","NCCN guidelines",20921461,"GDKD","Moon_et_al_21_SNV_4.csv",4,"Patient","lymphoma","NKT","SNV","10.1038/s43018-020-00161-w","Moon_et_al_21","targeted sequencing",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",0,"x"]
[55076,"B3","ATR","ATR","H1449Y","cancer_unspecified","any variant (LoF)","sensitivity","PARP Inhibitors","PARP Inhibitors","parp inhibitor","preclinical",23548269,"GDKD","Moon_et_al_21_SNV_4.csv",4,"Patient","lymphoma","NKT","SNV","10.1038/s43018-020-00161-w","Moon_et_al_21","targeted sequencing",{"$nulls":5},"NONE","None",0,"x"]
[55187,"B2","IDH2","IDH2","R172K","Acute Myeloid Leukemia","any mut.","sensitivity/response","Venetoclax","Venetoclax","bcl2 inhibitor","case report",30725494,"CIVIC","Moon_et_al_21_SNV_5.csv",5,"Patient","lymphoma","AITL","SNV","10.1038/s43018-020-00161-w","Moon_et_al_21","targeted sequencing","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic/Likely_pathogenic|_risk_factor",-1,"x"]
[55290,"B3","PTEN","PTEN","R130X","Melanoma","loss","resistance","Vemurafenib","Vemurafenib","raf inhibitor","preclinical",24265155,"CIVIC","Nguyen_et_al_17_targeted_SNV_AITL_PTCL02.csv","PTCL02","Patient","lymphoma","AITL","SNV","10.1038/bcj.2016.122","Nguyen_et_al_17","Targeted",{"$nulls":5},"NONE","NONE",0]
[55325,"B2","TP53","TP53","C176F","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Ng_et_al_2018_Supp_8_SNV_DL40.csv","DL-40","Cell line","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'CANCER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.95', 'Pipeline': 'deleterious'}","CANCER","Damaging","deleterious","-0.95","deleterious","Likely_pathogenic",-1,"x"]
[55535,"B2","TP53","TP53","R64X","Sarcoma","deleterious any mut.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",26646755,"CIVIC","Ng_et_al_2018_Supp_8_SNV_H9.csv","H9","Cell line","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[55607,"B3","ARID1A","ARID1A","1AA1AA","cancer_unspecified","any variant (lof) (LoF)","sensitivity","ATR Inhibitors","ATR Inhibitors","atr inhibitor","preclinical",27958275,"GDKD","Ng_et_al_2018_Supp_8_SNV_H9.csv","H9","Cell line","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[55835,"B2","TP53","TP53","frame-shift-delP153fs","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Ng_et_al_2018_Supp_8_SNV_HH.csv","HH","Cell line","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[55981,"B3","ATM","ATM","N1983S","Chronic Lymphocytic Leukemia","T2666A, any mut., R3008C, c.902-1G>T, c.7089+1del, c.7515+1-2del, K293*, F1025L, D1930V, E2187*, L2427P, F2732V, K468FS, D1682H, A2062V, C2488Y","resistance","Doxorubicin","Doxorubicin","anthracyclin","preclinical",23585524,"CIVIC","Ng_et_al_2018_Supp_8_SNV_HUT102.csv","HUT-102","Cell line","lymphoma","ATLL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","None",-1,"x"]
[56098,"B2","NRAS","NRAS","Q61K","Melanoma","G13D","sensitivity/response","Tanespimycin","Tanespimycin","hsp90 inhibitor","case report",18375819,"CIVIC","Ng_et_al_2018_Supp_8_SNV_HUT78.csv","HUT78","Cell line","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0]
[56206,"B2","TP53","TP53","R273C","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Ng_et_al_2018_Supp_8_SNV_Karpas299.csv","Karpas-299","Cell line","lymphoma","ALCL Alk+","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic/Likely_pathogenic",0,"x"]
[56271,"B2","NRAS","NRAS","Q61K","melanoma","any variant (GoF)","response","MEK Inhibitors","MEK Inhibitors","mek inhibitor","late trials","23414587, ASCO 2016 (abstr 9500)","GDKD","Ng_et_al_2018_Supp_8_SNV_Karpas384.csv","Karpas-384","Cell line","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0,"x"]
[56422,"B2","TP53","TP53","R248W","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Ng_et_al_2018_Supp_8_SNV_KHYG1.csv","KHYG-1","Cell line","lymphoma","NKT","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic","0.00006","x"]
[56483,"B3","KRAS","KRAS","G12A","Lung Non-small Cell Carcinoma","G12V","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",20609353,"CIVIC","Ng_et_al_2018_Supp_8_SNV_KHYG1.csv","KHYG-1","Cell line","lymphoma","NKT","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Conflicting_interpretations_of_pathogenicity",-1]
[56579,"B2","MET","MET","L515M","Lung Adenocarcinoma","exon 14 skipping any mut., ampl.","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","25971939, 26724472, 26729443, 26845194, 25922291, 25769807","CIVIC","Ng_et_al_2018_Supp_8_SNV_KIJK.csv","KIJK","Cell line","lymphoma","ALCL Alk+","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","None",-1,"x"]
[56612,"B3","MET","MET","L515M","cancer_unspecified","V1110I (GoF), H1112R (GoF), M1250I (GoF), R988C (GoF), T1010I (GoF)","sensitivity","Crizotinib","Crizotinib","met inhibitor","preclinical",17483355,"GDKD","Ng_et_al_2018_Supp_8_SNV_KIJK.csv","KIJK","Cell line","lymphoma","ALCL Alk+","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","None",-1]
[57040,"B2","ATM","ATM","E2932V","colorectal","any variant (LoF)","response","ATR Inhibitors","ATR Inhibitors","atr inhibitor","case report","ENA 2015 (abstract A48)","GDKD","Ng_et_al_2018_Supp_8_SNV_L82.csv","L82","Cell line","lymphoma","ALCL Alk+","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[57091,"B3","CDKN2A","CDKN2A","R21K","Skin Melanoma","loss","sensitivity/response","Alvocidib","Alvocidib","multi CDK inhibitor","preclinical",12777976,"CIVIC","Ng_et_al_2018_Supp_8_SNV_L82.csv","L82","Cell line","lymphoma","ALCL Alk+","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}",null,"-","deleterious","-0.93","deleterious","NONE",0]
[57194,"B2","TP53","TP53","frame-shift-del","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Ng_et_al_2018_Supp_8_SNV_MOTN1.csv","MOTN-1","Cell line","lymphoma","T-LGL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[57233,"B2","ATM","ATM","N1983S","gastric","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","ENA 2014 (abstr 8LBA)","GDKD","Ng_et_al_2018_Supp_8_SNV_MT2.csv","MT2","Cell line","lymphoma","ATLL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","None",-1,"x"]
[57278,"B3","CCND3","CCND3","S178A","T-cell Lymphoblastic Leukemia/lymphoma","loss","sensitivity/response","Palbociclib","Palbociclib","cdk4/6 inhibitor","preclinical",23079656,"CIVIC","Ng_et_al_2018_Supp_8_SNV_MT2.csv","MT2","Cell line","lymphoma","ATLL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","None",-1]
[57443,"B3","TP53","TP53","S215G","Vulva Squamous Cell Carcinoma","R158H","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Ng_et_al_2018_Supp_8_SNV_MTA.csv","MTA","Cell line","lymphoma","NKT","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Conflicting_interpretations_of_pathogenicity",-1]
[57483,"B2","TP53","TP53","frame-shift-del","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Ng_et_al_2018_Supp_8_SNV_NKL.csv","NKL","Cell line","lymphoma","NKT","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[57603,"B2","ATM","ATM","N1983S","Prostate Cancer","S2289*, N2875H, any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Ng_et_al_2018_Supp_8_SNV_SeAx.csv","SeAx","Cell line","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","None",-1,"x"]
[57729,"B2","TP53","TP53","G245S","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Ng_et_al_2018_Supp_8_SNV_SeAx.csv","SeAx","Cell line","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","Pathogenic","0.00002","x"]
[57852,"B3","PTEN","PTEN","I5V","Her2-receptor Positive Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Ng_et_al_2018_Supp_8_SNV_SeAx.csv","SeAx","Cell line","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Uncertain_significance",-1]
[57951,"B2","TP53","TP53","F113S","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Ng_et_al_2018_Supp_8_SNV_SMZ1.csv","SMZ-1","Cell line","lymphoma","NOS","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","NONE",0,"x"]
[58040,"B3","STK11","STK11","frame-shift-delframe-shift-del","cancer_unspecified","any variant (lof) (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19541609,"GDKD","Ng_et_al_2018_Supp_8_SNV_SR786.csv","SR786","Cell line","lymphoma","ALCL Alk+","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[58103,"B3","ATM","ATM","N1983S","Melanoma","any mut.","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","preclinical",23960094,"CIVIC","Ng_et_al_2018_Supp_8_SNV_ST1.csv","ST1","Cell line","lymphoma","ATLL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","None",-1,"x"]
[58230,"B2","TP53","TP53","R273H","myelodisplastic_syndrome","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Ng_et_al_2018_Supp_8_SNV_SUDHL1.csv","SUDHL1","Cell line","lymphoma","ALCL Alk+","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '-0.12', 'Pipeline': 'deleterious'}","CANCER","Neutral","tolerated","-0.12","deleterious","Pathogenic","0.00006","x"]
[58322,"B2","NRAS","NRAS","Q61K","Melanoma","Q61","resistance","Vemurafenib","Vemurafenib","raf inhibitor","clin. trials",23569304,"CIVIC","Ng_et_al_2018_Supp_8_SNV_TLBR-3.csv","TLBR-3","Cell line","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0]
[58464,"B2","KRAS","KRAS","G12R","gastrointestinal_stromal_tumor","G12 (GoF)","resistance","Imatinib","Imatinib","pdgfr inhibitor","case report",24687822,"GDKD","Ng_et_al_2018_Supp_9_SNV_DFTL-20763.csv","DFTL-20763","PDX","lymphoma","T-PLL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic",-1]
[58578,"B3","ATM","ATM","S2859F","lymphoma","any variant (LoF)","sensitivity","DNA-PKc Inhibitors","DNA-PKc Inhibitors","dna-pk inhibitor","preclinical",23761041,"GDKD","Ng_et_al_2018_Supp_9_SNV_DFTL-20763.csv","DFTL-20763","PDX","lymphoma","T-PLL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Uncertain_significance",0,"x"]
[58737,"B3","KRAS","KRAS","G12R","acute_myeloid_leukemia","any variant (GoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",22507781,"GDKD","Ng_et_al_2018_Supp_9_SNV_DFTL-20763.csv","DFTL-20763","PDX","lymphoma","T-PLL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Pathogenic",-1,"x"]
[58942,"B3","ATM","ATM","V2079I","Mantle Cell Lymphoma","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",20124459,"CIVIC","Ng_et_al_2018_Supp_9_SNV_DFTL-22685.csv","DFTL-22685","PDX","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","Benign/Likely_benign","0.00255","x"]
[59003,"B3","ATM","ATM","S2146T","glioma","any variant (LoF)","sensitivity","Temozolomide","Temozolomide","alkylating agent","preclinical",23960094,"GDKD","Ng_et_al_2018_Supp_9_SNV_DFTL-22685.csv","DFTL-22685","PDX","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","Benign/Likely_benign","0.00052","x"]
[59188,"B3","ATM","ATM","N1983S","All Solid Tumors","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",26510020,"OncoKB","Ng_et_al_2018_Supp_9_SNV_DFTL-47880.csv","DFTL-47880","PDX","lymphoma","AITL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[59298,"B2","ALK","ALK","T901A","lung_adeno","L1196M (GoF), E1408V (GoF)","response","Brigatinib","Brigatinib","alk inhibitor","case report","ASCO 2017 (abstr 9065)","GDKD","Ng_et_al_2018_Supp_9_SNV_DFTL-51398.csv","DFTL-51398","PDX","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","None",-1]
[59374,"B2","KIT","KIT","E306Kframe-shift-delM541L","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","case report",27371698,"CIVIC","Ng_et_al_2018_Supp_9_SNV_DFTL-51398.csv","DFTL-51398","PDX","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[59454,"B2","KIT","KIT","E306K","Melanoma","exon 11 any mut., any mut.","sensitivity/response","Imatinib","Imatinib","bcr-abl inhibitor","clin. trials","23775962, 21690468","CIVIC","Ng_et_al_2018_Supp_9_SNV_DFTL-51398.csv","DFTL-51398","PDX","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","Uncertain_significance",0,"x"]
[59597,"B2","KRAS","KRAS","I187V","Colorectal Cancer","G12D","sensitivity/response","Therapeutic Tumor Infiltrating Lymphocytes","Therapeutic Tumor Infiltrating Lymphocytes",null,"case report",27959684,"CIVIC","Ng_et_al_2018_Supp_9_SNV_DFTL-51398.csv","DFTL-51398","PDX","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",0]
[59689,"B3","ALK","ALK","T901A","Inflammatory Myofibroblastic Tumor","F1174L","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical",21030459,"CIVIC","Ng_et_al_2018_Supp_9_SNV_DFTL-51398.csv","DFTL-51398","PDX","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","None",-1]
[59698,"B3","ALK","ALK","T901A","lung_adeno","C1156Y (GoF)","sensitivity","Lorlatinib","Lorlatinib","ros inhibitor","preclinical",27401242,"GDKD","Ng_et_al_2018_Supp_9_SNV_DFTL-51398.csv","DFTL-51398","PDX","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","None",-1]
[60091,"B3","KRAS","KRAS","I187V","Cancer","any mut.","sensitivity/response","Trametinib","Trametinib","mek inhibitor","preclinical",22169769,"CIVIC","Ng_et_al_2018_Supp_9_SNV_DFTL-51398.csv","DFTL-51398","PDX","lymphoma","ALCL Alk-","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",0,"x"]
[60173,"B3","ARID1A","ARID1A","frame-shift-delframe-shift-del","cancer_unspecified","any mut. (lof) (LoF)","sensitivity","EZH2 Inhibitors In RAS Wt","EZH2 Inhibitors In RAS Wt","ezh2 inhibitor","preclinical",26552009,"GDKD","Ng_et_al_2018_Supp_9_SNV_DFTL-58239.csv","DFTL-58239","PDX","lymphoma","CTCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[60353,"B3","ALK","ALK","T1012M","Neuroblastoma","F1174L, R1275Q","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical","21948233, 22072639","CIVIC","Ng_et_al_2018_Supp_9_SNV_DFTL-78024.csv","DFTL-78024","PDX","lymphoma","AITL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","Benign/Likely_benign","0.00067"]
[60425,"B3","ARID1A","ARID1A","frame-shift-del","Ovarian Clear Cell Carcinoma","(LoF)","sensitivity/response","GSK126","GSK126","ezh2 inhibitor","preclinical",25686104,"CIVIC","Ng_et_al_2018_Supp_9_SNV_DFTL-82248.csv","DFTL-82248","PDX","lymphoma","NOS","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","NONE",0]
[60663,"B2","PLCG2","PLCG2","N571S","chronic_lymphocytic_leukemia","R665W, L845F (GoF)","resistance","Ibrutinib","Ibrutinib","btk inhibitor","early trials",24869598,"GDKD","Ng_et_al_2018_Supp_9_SNV_DFTL81777.csv","CBTL-81777","PDX","lymphoma","HS-TCL","SNV","10.1038/s41467-018-04356-9","Ng_et_al_2018","Targeted",{"$nulls":5},"NONE","Benign","0.00751"]
[60736,"B1","IDH2","IDH2","R172K","Acute Myeloid Leukemia","any mut., oncogenic any mut.s","sensitivity/response","Enasidenib","Enasidenib","idh2 inhibitor","approved",28588020,"CIVIC, OncoKB","Odejide_et_al_14_targeted_SNV_AITL_105.csv",105,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic/Likely_pathogenic|_risk_factor",-1,"x"]
[60811,"B2","DNMT3A","DNMT3A","G308D","Acute Myeloid Leukemia","R882","sensitivity/response","Idarubicin","Idarubicin","anthracyclin","clin. trials",22081665,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_118.csv",118,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[60861,"B2","TP53","TP53","M133R","Sarcoma","deleterious any mut.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",26646755,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_23.csv",23,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'CANCER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.95', 'Pipeline': 'deleterious'}","CANCER","Damaging","deleterious","-0.95","deleterious","None",-1,"x"]
[60955,"B3","TP53","TP53","R248Q","Vulva Squamous Cell Carcinoma","R158H","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_40.csv",40,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic",0]
[60990,"B2","KIT","KIT","Y774H","Melanoma","D820Y","resistance","Imatinib","Imatinib","kit inhibitor","case report",21642685,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_58.csv",58,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1]
[61015,"B2","KIT","KIT","Y774H","Systemic Mastocytosis","D816V","sensitivity/response","Midostaurin","Midostaurin","multi TKI","clin. trials",27355533,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_58.csv",58,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1]
[61040,"B3","KIT","KIT","Y774H","Gastrointestinal Stromal Tumor","V654A, T670I","resistance","Imatinib","Imatinib","bcr-abl inhibitor","preclinical","16954519, 25239608","CIVIC","Odejide_et_al_14_targeted_SNV_AITL_58.csv",58,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1]
[61117,"B2","DNMT3A","DNMT3A","R736C","Acute Myeloid Leukemia","any mut.","sensitivity/response","Decitabine","Decitabine","demethylating agent","clin. trials",22124213,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_68.csv",68,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Conflicting_interpretations_of_pathogenicity","0.00006","x"]
[61205,"B2","ABL1","ABL1","T1084S","Chronic Myeloid Leukemia","BCR::ABL F359V, BCR::ABL M244V, BCR::ABL L248V, BCR::ABL G250E, BCR::ABL Q252H, BCR::ABL E255V, BCR::ABL Y253F, BCR::ABL E255K, BCR::ABL E355G, BCR::ABL T315I, BCR::ABL F317L, BCR::ABL S417Y, BCR::ABL M351T, BCR::ABL H396R, BCR::ABL D363G, BCR::ABL E98G, BCR::ABL L364I, BCR::ABL F486S, BCR::ABL E459K, Double Ph, P-Loop any mut.","resistance","Imatinib","Imatinib","bcr-abl inhibitor","case report","12623848, 15930265, 22371878, 16775234","CIVIC","Odejide_et_al_14_targeted_SNV_AITL_84.csv",84,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}",null,"-","deleterious","-0.93","deleterious","NONE",0,"x"]
[61276,"B2","JAK2","JAK2","V617F","Polycythemia Vera","V617F","sensitivity/response","Peginterferon Alfa-2b","Peginterferon Alfa-2b","interferon","clin. trials",16709929,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_85.csv",85,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity","0.00049","x"]
[61418,"B3","KRAS","KRAS","Q22K","Ovarian Cancer","any mut.","sensitivity/response","Decitabine","Decitabine","demethylating agent","preclinical",25968887,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_89.csv",89,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Likely_pathogenic",-1,"x"]
[61460,"B3","KRAS","KRAS","Q22K","Cancer","any mut.","sensitivity/response","Trametinib","Trametinib","mek inhibitor","preclinical",22169769,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_89.csv",89,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Likely_pathogenic",-1,"x"]
[61566,"B3","TP53","TP53","R248Q","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Odejide_et_al_14_targeted_SNV_AITL_99.csv",99,"Patient","lymphoma","AITL","SNV","10.1182/blood-2013-10-531509","Odejide_et_al_14","Targeted","{'FATHMM': 'CANCER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.58', 'Pipeline': 'deleterious'}","CANCER","Neutral","deleterious","-0.58","deleterious","Pathogenic",0,"x"]
[61593,"B2","ALK","ALK","Q286R","lung_adeno","L1198F (GoF)","resistance","Lorlatinib","Lorlatinib","alk inhibitor","case report",26698910,"GDKD","Palomero_et_al_14_WES_SNV_AITL_35.csv",35,"Patient","lymphoma","AITL","SNV","10.1038/ng.2873","Palomero_et_al_14","WES",{"$nulls":5},"NONE","None",-1]
[61647,"B3","ATM","ATM","R3008H","lymphoma","any variant (LoF)","sensitivity","DNA-PKc Inhibitors","DNA-PKc Inhibitors","dna-pk inhibitor","preclinical",23761041,"GDKD","Palomero_et_al_14_WES_SNV_NOS_33.csv",33,"Patient","lymphoma","NOS","SNV","10.1038/ng.2873","Palomero_et_al_14","WES",{"$nulls":5},"NONE","Pathogenic/Likely_pathogenic",0,"x"]
[61709,"B2","DNMT3A","DNMT3A","R882C","Acute Myeloid Leukemia","any mut.","sensitivity/response","Decitabine","Decitabine","demethylating agent","clin. trials",22124213,"CIVIC","Sakata_et_al_14_targeted_SNV_AITL_PTCL56.csv","PTCL56","Patient","lymphoma","AITL","SNV","10.1038/ng.2872","Sakata_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic","0.00005","x"]
[61731,"B2","IDH2","IDH2","R172M","Acute Myeloid Leukemia","any mut.","sensitivity/response","Venetoclax","Venetoclax","bcl2 inhibitor","case report",30725494,"CIVIC","Sakata_et_al_14_targeted_SNV_AITL_PTCL61.csv","PTCL61","Patient","lymphoma","AITL","SNV","10.1038/ng.2872","Sakata_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic/Likely_pathogenic|_risk_factor",-1,"x"]
[61893,"B2","DNMT3A","DNMT3A","R736H","Acute Myeloid Leukemia","R882","sensitivity/response","Idarubicin","Idarubicin","anthracyclin","clin. trials",22081665,"CIVIC","Sakata_et_al_14_targeted_SNV_PTCL_NOS_PTCL43.csv","PTCL43","Patient","lymphoma","NOS","SNV","10.1038/ng.2872","Sakata_et_al_14","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Pathogenic",0]
[61934,"B2","PTEN","PTEN","R130X","Breast Cancer","loss","resistance","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials","24387334, 21594665","CIVIC","Sakata_et_al_14_WES_SNV_AITL_PTCL2.csv","PTCL2","Patient","lymphoma","AITL","SNV","10.1038/ng.2872","Sakata_et_al_14","WES",{"$nulls":5},"NONE","NONE",0]
[62029,"B2","IDH2","IDH2","V8A","acute_myeloid_leukemia","R140Q switch-of-function, R172K switch-of-function","response","IDH2 Inhibitor","IDH2 Inhibitor","idh2 inhibitor","early trials","AACR 2014 (abstr CT103)","GDKD","Schatz_et_al_15_targeted_SNV_PTCL_NOS_T06.csv","T06","Patient","lymphoma","NOS","SNV","10.1038/leu.2014.261","Schatz_et_al_15","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance","0.00125"]
[62072,"B2","BRCA2","BRCA2","K436E","Her2-receptor Negative Breast Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials",28578601,"CIVIC","Schatz_et_al_15_targeted_SNV_PTCL_NOS_T39.csv","T39","Patient","lymphoma","NOS","SNV","10.1038/leu.2014.261","Schatz_et_al_15","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[62178,"B3","NF1","NF1","P678fsP678fs","glioma","any variant (lof) (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19573811,"GDKD","Schatz_et_al_15_targeted_SNV_PTCL_NOS_T69.csv","T69","Patient","lymphoma","NOS","SNV","10.1038/leu.2014.261","Schatz_et_al_15","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[62193,"B2","ATM","ATM","A3006T","bladder","any variant (LoF)","response","Cisplatin","Cisplatin","platinum","early trials",26238431,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP001.csv","TP001","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Uncertain_significance",-1,"x"]
[62257,"B3","ATM","ATM","L2427P","glioma","any variant (LoF)","sensitivity","Temozolomide","Temozolomide","alkylating agent","preclinical",23960094,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP003.csv","TP003","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance",-1,"x"]
[62376,"B3","SH2B3","SH2B3","P269R","myeloproliferative_neoplasm","any variant (LoF)","sensitivity","JAK Inhibitors","JAK Inhibitors","jak inhibitor","preclinical",20404132,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP008.csv","TP008","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[62393,"B2","ALK","ALK","L609M","Neuroblastoma","R1275Q, F1174L","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",23598171,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP010.csv","TP010","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[62480,"B3","ATM","ATM","Q1906X","lymphoma","any variant (LoF)","sensitivity","DNA-PKc Inhibitors","DNA-PKc Inhibitors","dna-pk inhibitor","preclinical",23761041,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP011.csv","TP011","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[62504,"B3","ATM","ATM","2436-2439del","All Solid Tumors","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",26510020,"OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP013.csv","TP013","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[63434,"B1","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 17 any mut.s","sensitivity/response","Regorafenib","Regorafenib","multi TKI","approved",23177515,"OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[64696,"B2","BRCA1","BRCA1","P824L","Pancreatic Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials",25366685,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[65952,"B2","BRCA1","BRCA1","K1136R","breast","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","20609467, 25366685","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",0,"x"]
[66785,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","T417-D419delinsY, F506-F508DUP, K484-G487DEL, Exon 13 any mut., V559D","sensitivity/response","Imatinib","Imatinib","kit inhibitor","case report","18955451, 14645423, 22114577","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[66873,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","wildtype, exon 11 any mut., exon 9 any mut.","sensitivity/response","Regorafenib","Regorafenib","multi TKI","clin. trials","27371698, 23177515, 22614970","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[66957,"B2","MET","MET","R988C","Lung Non-small Cell Carcinoma","D1228N","resistance","Crizotinib","Crizotinib","alk inhibitor","case report",27343442,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1]
[67006,"B2","MET","MET","R988C","Non-Small Cell Lung Cancer","ampl., D1010H, D1010N, D1010Y, Exon 14 del., Exon 14 splice any mut., Y1003C, Y1003F, Y1003N","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials","21623265, 25971939, 26729443","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[67567,"B3","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","N822K, T670I","resistance","Regorafenib","Regorafenib","multi TKI","preclinical",25239608,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP015.csv","TP015","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[68558,"B2","ATM","ATM","R2453P","gastric","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","ENA 2014 (abstr 8LBA)","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP016.csv","TP016","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Uncertain_significance",-1,"x"]
[69541,"B2","BRCA1","BRCA1","P824L","Ovarian Cancer","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP016.csv","TP016","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[70964,"B2","BRCA1","BRCA1","S1634G","Pancreatic Cancer","any mut.","sensitivity/response","Veliparib","Veliparib","parp inhibitor","clin. trials",29223478,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP016.csv","TP016","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[71873,"B2","BRCA2","BRCA2","N372H","Triple-receptor Negative Breast Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials",21862407,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP016.csv","TP016","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","NONE",0,"x"]
[71933,"B2","RET","RET","K965E","Thyroid Gland Medullary Carcinoma","M918T","sensitivity/response","Sorafenib","Sorafenib","multi TKI","clin. trials",20368568,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP016.csv","TP016","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[72370,"B2","ALK","ALK","D1529E","inflammatory_myofibroblastic_tumor","G1128A (GoF)","resistance","Crizotinib","Crizotinib","met inhibitor","case report","http://ascopubs.org/doi/full/10.1200/PO.17.00015","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP017.csv","TP017","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[72381,"B2","ATM","ATM","L319R","bladder","any variant (LoF)","response","Cisplatin","Cisplatin","platinum","early trials",26238431,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP017.csv","TP017","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[72776,"B3","ALK","ALK","D1529E","Neuroblastoma","F1174L","sensitivity/response","AZD3463","AZD3463","igf1r inhibitor","preclinical",26786851,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP017.csv","TP017","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[72807,"B3","ATM","ATM","L319R","Glioblastoma","any mut.","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","preclinical",23960094,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP017.csv","TP017","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[73835,"B1","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 17 any mut.s","sensitivity/response","Regorafenib","Regorafenib","multi TKI","approved",23177515,"OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[103240,"B2","ALK","ALK","D1529E","Neuroblastoma","I1171T","sensitivity/response","Ceritinib","Ceritinib","alk inhibitor","case report",29907598,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP028.csv","TP028","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[75143,"B2","BRCA1","BRCA1","P824L","Pancreatic Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials",25366685,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[76498,"B2","BRCA1","BRCA1","S1634G","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","19553641, 25366685, 26510020","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[77195,"B2","BRCA2","BRCA2","N372H","Pancreatic Cancer","any mut.","sensitivity/response","Iniparib","Iniparib","parp inhibitor","case report",21508395,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","NONE",0,"x"]
[77298,"B2","KIT","KIT","M537L","melanoma","exon 11 p.550-592, exon 13 p.627-664 (GoF)","response","Dasatinib","Dasatinib","bcr-abl inhibitor","case report",19671763,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[77342,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 11 any mut., exon 9 any mut., ampl. (expr.)","sensitivity/response","Imatinib","Imatinib","kit inhibitor","clin. trials","14645423, 16624552, 18955451","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[77414,"B2","KIT","KIT","M537L","gastrointestinal_stromal_tumor","exon 14 p.664-714 (GoF), exon 13 p.627-664 (GoF)","decreased sensitivity","Imatinib","Imatinib","kit inhibitor","late trials",18955458,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[77501,"B2","MET","MET","T992I","Lung Non-small Cell Carcinoma","exon 14 skipping any mut.","sensitivity/response","Tepotinib","Tepotinib","met inhibitor","clin. trials",160289,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.01111","x"]
[77621,"B3","ALK","ALK","D1529E","Neuroblastoma","F1174L, R1275Q","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical","21948233, 22072639","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[78201,"B3","KIT","KIT","M537L","gastrointestinal_stromal_tumor","exon 17 p.788-828 (GoF)","sensitivity","Sorafenib","Sorafenib","multi TKI","preclinical",23840364,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[78212,"B3","MET","MET","T992I","Cancer","exon 14 skipping any mut.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",26547802,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP018.csv","TP018","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.01111","x"]
[79453,"B2","BRCA1","BRCA1","S408I","Her2-receptor Negative Breast Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","28578601, 28792849","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP019.csv","TP019","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[79676,"B2","BRCA1","BRCA1","S408I","Ovarian Cancer","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP019.csv","TP019","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[80937,"B2","BRCA2","BRCA2","N372H","Ovarian Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","23346317, 21862407","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP019.csv","TP019","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","NONE",0,"x"]
[80987,"B2","PTCH1","PTCH1","P1249L","Medulloblastoma","any mut.","sensitivity/response","Sonidegib","Sonidegib","hedgehog inhibitor","clin. trials",24651015,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP019.csv","TP019","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[82208,"B2","ALK","ALK","D1529E","lung_adeno","L1196M (GoF), E1408V (GoF)","response","Brigatinib","Brigatinib","alk inhibitor","case report","ASCO 2017 (abstr 9065)","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[106682,"B1","ALK","ALK","D1529E","lung_adeno","L1196M (GoF), S1206Y (GoF), G1269A (GoF), I1171T (GoF)","response","Ceritinib","Ceritinib","alk inhibitor","FDA-approved","24670165, 24327273, 24670165, 25228534","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP033.csv","TP033","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[83108,"B2","BRCA1","BRCA1","P824L","Triple-receptor Negative Breast Cancer","any mut.","resistance","Olaparib","Olaparib","parp inhibitor","clin. trials",21862407,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[84603,"B2","BRCA1","BRCA1","S1634G","Ovarian Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1]
[85500,"B2","BRCA1","BRCA1","S1566G","ovarian","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","late trials","22406760, 22711857","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[85745,"B2","ERBB2","ERBB2","A1186D","Breast Cancer","any mut.","sensitivity/response","Neratinib","Neratinib","egfr inhibitor","clin. trials",28679771,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[85901,"B2","KIT","KIT","M537L","melanoma","D820Y (GoF)","response","Nilotinib","Nilotinib","bcr-abl inhibitor","case report",25695690,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[85945,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","wildtype, exon 11 any mut., exon 9 any mut.","sensitivity/response","Regorafenib","Regorafenib","multi TKI","clin. trials","27371698, 23177515, 22614970","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[86035,"B3","ALK","ALK","K1491R","Neuroblastoma","F1174L","sensitivity/response","AZD3463","AZD3463","alk inhibitor","preclinical",26786851,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[86116,"B3","ALK","ALK","K1491R","glioma","F1174L (GoF)","reduced sensitivity","Crizotinib","Crizotinib","met inhibitor","preclinical",22072639,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[86198,"B3","BRCA1","BRCA1","E991G","Endometrioid Ovary Carcinoma","W1815X","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",23415752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[86665,"B3","ERBB2","ERBB2","A1201D","breast","T798I (GoF)","sensitivity","Afatinib","Afatinib","her2 inhibitor","preclinical",28274957,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[87019,"R1(OncoKB)","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","T670I, V654A","resistance","Imatinib","Imatinib","pdgfr inhibitor","unspecified","16551858, 1675110, 16954519, 17545544, 17699867, 23840364, 16551858, 16954519, 18955458, 23840364","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP020.csv","TP020","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[87251,"B2","KDR","KDR","V297I","Colorectal Adenocarcinoma","R961W","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",27004155,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP021.csv","TP021","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","NONE",0]
[87281,"B2","MET","MET","R970C","Head And Neck Cancer","R1004G","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",31391294,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP021.csv","TP021","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.0049"]
[87461,"B2","PIK3CA","PIK3CA","I391M","gastric","any variant (GoF)","response","PI3K Alpha Inhibitors","PI3K Alpha Inhibitors","pi3k/akt inhibitor","case report","ASCO 2015 (abstr 2501)","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP021.csv","TP021","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","NONE",0,"x"]
[87501,"B2","PIK3CA","PIK3CA","I391M","Colorectal Cancer","E542K","resistance","Regorafenib","Regorafenib","multi TKI","clin. trials",26184520,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP021.csv","TP021","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","NONE",0]
[87625,"B3","ALK","ALK","D1529E","Inflammatory Myofibroblastic Tumor","F1174L","resistance","Crizotinib","Crizotinib","met inhibitor","preclinical",21030459,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP021.csv","TP021","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[87666,"B3","ALK","ALK","K1491R","lung_adeno","F1174L (GoF)","sensitivity","Novel ALK Inhibiors","Novel ALK Inhibiors","alk inhibitor","preclinical",24327273,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP021.csv","TP021","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[87838,"B3","PIK3CA","PIK3CA","I391M","Head And Neck Cancer","H1047R","sensitivity/response","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",25550549,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP021.csv","TP021","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","NONE",0]
[89006,"B1","BRCA1","BRCA1","S1634G","Ovarian Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","approved",30345884,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP022.csv","TP022","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[89348,"B2","BRCA1","BRCA1","K1136R","pancreatic","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","case report","25366685, 25719666","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP022.csv","TP022","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",0,"x"]
[92512,"B2","BRCA1","BRCA1","S1566G","Ovarian Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP022.csv","TP022","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[92659,"B2","BRCA1","BRCA1","S1634G","Pancreatic Cancer","any mut.","sensitivity/response","Veliparib","Veliparib","parp inhibitor","clin. trials",29223478,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP022.csv","TP022","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[94028,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","case report",27371698,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP022.csv","TP022","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[94088,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 11 any mut., exon 9 any mut., ampl. (expr.)","sensitivity/response","Imatinib","Imatinib","bcr-abl inhibitor","clin. trials","14645423, 16624552, 18955451","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP022.csv","TP022","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[94164,"B2","KIT","KIT","M537L","gastrointestinal_stromal_tumor","exon 9 p.449-514 (GoF)","decreased sensitivity","Imatinib (low Dose)","Imatinib","kit inhibitor","late trials","18955458, 18955451, 16624552","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP022.csv","TP022","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[129602,"B2","ALK","ALK","D1529E","Lung Non-small Cell Carcinoma","fusion, any mut.","sensitivity/response","Ceritinib","Ceritinib","alk inhibitor","clin. trials","26973324, 24670165","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP071.csv","TP071","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[94965,"B2","ALK","ALK","K1491R","Neuroblastoma","R1275Q, F1174L","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",23598171,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP023.csv","TP023","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[95163,"B2","BRCA1","BRCA1","E991G","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","19553641, 25366685, 26510020","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP023.csv","TP023","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[95210,"B2","BRCA2","BRCA2","N372H","Pancreatic Cancer","any mut.","sensitivity/response","Platinum Compound","Platinum Compound","platinum","clin. trials",25072261,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP023.csv","TP023","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","NONE",0,"x"]
[95386,"B3","ALK","ALK","D1529E","glioma","F1174L (GoF)","reduced sensitivity","Crizotinib","Crizotinib","alk inhibitor","preclinical",22072639,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP023.csv","TP023","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[95434,"B3","ATM","ATM","Y2437D","Hematologic Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",20739657,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP023.csv","TP023","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0,"x"]
[95503,"B2","ATM","ATM","V2951I","bladder","any variant (LoF)","response","Cisplatin","Cisplatin","platinum","early trials",26238431,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP024.csv","TP024","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[96274,"B1","BRCA1","BRCA1","K1136R","Ovarian Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","approved",30345884,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",0,"x"]
[96439,"B2","ATM","ATM","L2877F","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[98446,"B2","BRCA1","BRCA1","S1566G","Ovarian Carcinoma","any mut.","sensitivity/response","Platinum Compound","Platinum Compound","platinum","clin. trials",24240112,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[98946,"B2","BRCA1","BRCA1","S1566G","breast","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","20609467, 25366685","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[99827,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","D820Y, N822K","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",22614970,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[99887,"B2","KIT","KIT","M537L","Melanoma","exon 11 any mut., any mut.","sensitivity/response","Imatinib","Imatinib","kit inhibitor","clin. trials","23775962, 21690468","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[100086,"B3","ALK","ALK","D1529E","Neuroblastoma","F1174L","sensitivity/response","Alectinib","Alectinib","alk inhibitor","preclinical",21575866,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[100433,"B3","FBXW7","FBXW7","R361L","Cancer","(LoF)","sensitivity/response","Sirolimus","Sirolimus","mtor inhibitor","preclinical",18787170,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}",null,"-","deleterious","-0.93","deleterious","None",-1]
[100697,"R1(OncoKB)","ALK","ALK","D1529E","Non-Small Cell Lung Cancer","C1156Y, G1269A, L1196M","resistance","Crizotinib","Crizotinib","alk inhibitor","unspecified","20979473, 22235099, 23434628, 24675041, 26144315, 26698910, 27045755, 22235099, 23344087, 23434628, 24675041, 27045755, 28434515, 22235099, 22277784, 23344087, 23434628, 24675041, 27432227, 28434515","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP025.csv","TP025","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[100964,"B2","BRCA1","BRCA1","E991G","cancer_unspecified","any variant (LoF)","response","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","case report",25964244,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP026.csv","TP026","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[101597,"B2","SMO","SMO","V157M","Medulloblastoma","D473H","resistance","Vismodegib","Vismodegib","hedgehog inhibitor","case report",19726788,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP026.csv","TP026","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[101646,"B3","ALK","ALK","K1491R","Inflammatory Myofibroblastic Tumor","F1174L","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical",21030459,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP026.csv","TP026","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[101685,"B3","ALK","ALK","D1529E","lung_adeno","F1174L (GoF)","sensitivity","Novel ALK Inhibiors","Novel ALK Inhibiors","alk inhibitor","preclinical",24327273,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP026.csv","TP026","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[102028,"B2","BRCA1","BRCA1","P824L","Prostate Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP027.csv","TP027","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[102562,"B2","BRCA2","BRCA2","N372H","Ovarian Cancer","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP027.csv","TP027","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","NONE",0,"x"]
[102690,"B2","KIT","KIT","M537L","melanoma","D820Y (GoF)","response","Imatinib","Imatinib","kit inhibitor","case report",23775962,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP027.csv","TP027","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[102782,"B2","KIT","KIT","M537L","gastrointestinal_stromal_tumor","exon 17 p.788-828 (GoF)","response","Nilotinib","Nilotinib","bcr-abl inhibitor","early trials","22119758, 21456006","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP027.csv","TP027","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[103127,"B3","KIT","KIT","M537L","acute_myeloid_leukemia","exon 8 p.416-422 (GoF)","sensitivity","Imatinib","Imatinib","pdgfr inhibitor","preclinical",15618474,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP027.csv","TP027","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[103205,"A2","EZH2","EZH2","Y726D","Follicular Lymphoma","oncogenic any mut.s","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","clin. trials",null,"OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP028.csv","TP028","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[103421,"B3","ALK","ALK","D1529E","lung_adeno","F1174L (GoF)","sensitivity","Novel ALK Inhibiors","Novel ALK Inhibiors","alk inhibitor","preclinical",24327273,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP028.csv","TP028","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[103503,"B3","EZH2","EZH2","Y687D","Skin Melanoma","Y646","sensitivity/response","GSK126","GSK126","ezh2 inhibitor","preclinical",26304929,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP028.csv","TP028","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1]
[103708,"B2","BRCA1","BRCA1","R1300G","Ovarian Cancer","any mut.","sensitivity/response","Rucaparib","Rucaparib","parp inhibitor","clin. trials",27908594,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP030.csv","TP030","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[103798,"B2","FCGR3A","FCGR3A","N231Y","Breast Cancer","F212V","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","clin. trials",24989892,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP030.csv","TP030","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[103857,"B3","ALK","ALK","V476A","Neuroblastoma","exon 4-11 del.","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","preclinical",27049722,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP030.csv","TP030","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[104003,"B1","BRCA2","BRCA2","N372H","Ovarian Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","approved",30345884,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP031.csv","TP031","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","NONE",0,"x"]
[104057,"B2","ALK","ALK","D1529E","lung_adeno","L1198F (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",26698910,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP031.csv","TP031","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[104222,"B3","ALK","ALK","K1491R","Neuroblastoma","exon 4-11 del.","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","preclinical",27049722,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP031.csv","TP031","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[104257,"B3","ALK","ALK","D1529E","glioma","R1275Q (GoF), G1128A (GoF), I1171N (GoF), R1192P (GoF), F1245C (GoF)","sensitivity","Crizotinib","Crizotinib","met inhibitor","preclinical",22072639,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP031.csv","TP031","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[104392,"B2","ALK","ALK","K1491R","Neuroblastoma","R1275Q, F1174L","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",23598171,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[104432,"B2","ERBB2","ERBB2","G213S","Lung Adenocarcinoma","Kinase Domain any mut., Y772-A775DUP, G776L, G778-P780DUP","sensitivity/response","Afatinib","Afatinib","her2 inhibitor","case report","22325357, 26559459","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[104723,"B2","ERBB2","ERBB2","A1186D","breast","V659E (GoF)","response","Lapatinib","Lapatinib","her2 inhibitor","case report",23950206,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1]
[104867,"B2","ERBB2","ERBB2","A1186D","lung_adeno","G776L (GoF)","response","Trastuzumab-based Therapy","Trastuzumab-based Therapy","her2 inhibitor","case report",16775247,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1]
[105524,"B3","ALK","ALK","K1491R","Neuroblastoma","F1174L","sensitivity/response","Alectinib","Alectinib","alk inhibitor","preclinical",21575866,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[105560,"B3","ALK","ALK","K1491R","acute_lymphocytic_leukemia","F856S (GoF), A348D (GoF)","sensitivity","Crizotinib","Crizotinib","alk inhibitor","preclinical",26032424,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[105577,"B3","ERBB2","ERBB2","G228S","cancer_unspecified","E321G (GoF), C334S (GoF)","sensitivity","ERBB2 TKIs","ERBB2 TKIs","her2 inhibitor","preclinical",22908275,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[106261,"B3","ERBB2","ERBB2","G228S","breast","T798I (GoF)","sensitivity","Afatinib","Afatinib","her2 inhibitor","preclinical",28274957,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[106404,"B3","ERBB2","ERBB2","G213S","breast","K753E (GoF), L755S (GoF)","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical","27697991, 23220880","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP032.csv","TP032","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[106843,"B2","ALK","ALK","V476A","Neuroblastoma","R1275Q, F1174L","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",23598171,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP033.csv","TP033","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[107202,"B2","BRCA1","BRCA1","E991G","Ovarian Carcinoma","any mut.","sensitivity/response","Platinum Compound","Platinum Compound","platinum","clin. trials",24240112,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP033.csv","TP033","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[107489,"B3","ALK","ALK","D1529E","Neuroblastoma","F1174L","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical",22072639,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP033.csv","TP033","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[107580,"B3","CSF1R","CSF1R","G413S","myeloproliferative_neoplasm","Y571D (GoF)","sensitivity","Imatinib","Imatinib","kit inhibitor","preclinical",18971950,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP033.csv","TP033","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","Benign","0.01375"]
[107691,"B2","KIT","KIT","M537L","Melanoma","S628N","sensitivity/response","Imatinib","Imatinib","kit inhibitor","case report",25317746,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP046.csv","TP046","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[107743,"B2","KIT","KIT","M537L","melanoma","D820Y (GoF)","response","Imatinib","Imatinib","kit inhibitor","case report",23775962,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP046.csv","TP046","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[107791,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","clin. trials",22614970,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP046.csv","TP046","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[107906,"B3","ATM","ATM","T1953A","Glioblastoma","any mut.","sensitivity/response","Temozolomide","Temozolomide","alkylating agent","preclinical",23960094,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP046.csv","TP046","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0,"x"]
[108160,"B3","KIT","KIT","M537L","acute_myeloid_leukemia","exon 8 p.416-422 (GoF)","sensitivity","Imatinib","Imatinib","pdgfr inhibitor","preclinical",15618474,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP046.csv","TP046","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[109227,"B2","BRCA1","BRCA1","S509G","cancer_unspecified","any variant (LoF)","response","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","case report",25964244,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP047.csv","TP047","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[110272,"B2","BRCA1","BRCA1","E991G","Pancreatic Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials",25366685,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP047.csv","TP047","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[112227,"B2","BRCA1","BRCA1","S509G","ovarian","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","late trials","22406760, 22711857","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP047.csv","TP047","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[112409,"B3","BRCA1","BRCA1","S509G","Endometrioid Ovary Carcinoma","W1815X","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",23415752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP047.csv","TP047","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[114578,"B2","BRCA1","BRCA1","S1634G","Her2-receptor Negative Breast Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","28578601, 28792849","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP067.csv","TP067","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[115641,"B2","BRCA1","BRCA1","E991G","Ovarian Cancer","any mut.","sensitivity/response","Rucaparib","Rucaparib","parp inhibitor","clin. trials",27908594,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP067.csv","TP067","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[116876,"B2","RNF43","RNF43","R482W","colorectal","any variant (GoF)","response","Porcupine Inhibitors","Porcupine Inhibitors","wnt inhibitor","case report","ENA 2015 (abstract C45)","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP067.csv","TP067","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[117257,"B3","SETD2","SETD2","P1962L","cancer_unspecified","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical","ENA 2014 (abstr 211)","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP067.csv","TP067","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","NONE",0,"x"]
[117359,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","N822K, Y823D, C809G, D820A, D820G, D816H, T670I","resistance","Imatinib","Imatinib","kit inhibitor","case report",16954519,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP068.csv","TP068","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[117435,"B2","KIT","KIT","M537L","thymic","D820E (GoF)","response","Sorafenib","Sorafenib","multi TKI","case report",19461405,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP068.csv","TP068","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[117495,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","V654A, Exon 9 any mut., V569-L576DEL","sensitivity/response","Sunitinib","Sunitinib","multi TKI","clin. trials","16638875, 22439647, 18955458, 26772734","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP068.csv","TP068","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[117685,"B3","KIT","KIT","M537L","Cancer","V560D","sensitivity/response","Imatinib Mesylate","Imatinib Mesylate","bcr-abl inhibitor","preclinical",18955458,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP068.csv","TP068","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[117877,"B3","KIT","KIT","M537L","gastrointestinal_stromal_tumor","exon 17 p.788-828 (GoF)","sensitivity","Sorafenib","Sorafenib","multi TKI","preclinical",23840364,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP068.csv","TP068","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[119376,"B2","BRCA1","BRCA1","S1634G","cancer_unspecified","any variant (LoF)","response","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","case report",25964244,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP069.csv","TP069","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[120603,"B2","BRCA1","BRCA1","E991G","Her2-receptor Negative Breast Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","28578601, 28792849","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP069.csv","TP069","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[122405,"B2","BRCA1","BRCA1","P824L","Ovarian Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP069.csv","TP069","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[123696,"B2","BRCA1","BRCA1","S1634G","ovarian","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","late trials","22406760, 22711857","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP069.csv","TP069","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[123927,"B3","BRCA1","BRCA1","D825Y","Endometrioid Ovary Carcinoma","W1815X","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",23415752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP069.csv","TP069","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.00003"]
[124408,"R1(OncoKB)","PDGFRA","PDGFRA","G79D","Gastrointestinal Stromal Tumor","D842V","resistance","Imatinib","Imatinib","kit inhibitor","unspecified","12949711, 15685537, 15928335, 17087936, 18794084, 18955458, 22718859, 22745105, 23752188, 24963404, 25905001","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP069.csv","TP069","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[125302,"B2","ALK","ALK","K1491R","lung_adeno","L1198F (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",26698910,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[125434,"B2","BRCA1","BRCA1","P824L","pancreatic","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","case report","25366685, 25719666","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[126566,"B2","BRCA1","BRCA1","S1566G","Pancreatic Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials",25366685,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[128530,"B2","BRCA1","BRCA1","K1136R","ovarian","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","late trials","22406760, 22711857","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",0,"x"]
[128705,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","D820Y, N822K","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",22614970,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[128773,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","clin. trials",22614970,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[128877,"B3","ALK","ALK","D1529E","Neuroblastoma","F1174L, R1275Q","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical","21948233, 22072639","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[129256,"B3","FLT3","FLT3","D7G","Cancer","D835Y","sensitivity/response","Gilteritinib","Gilteritinib","flt3 inhibitor","preclinical",28516360,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0]
[129272,"B3","FLT3","FLT3","D7G","acute_myeloid_leukemia","F691 (GoF)","sensitivity","Novel FLT3 Inhibitors","Novel FLT3 Inhibitors","flt3 inhibitor","preclinical","25847190, 25847190","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP070.csv","TP070","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0]
[129579,"B2","ALK","ALK","K1491R","inflammatory_myofibroblastic_tumor","G1128A (GoF)","resistance","Crizotinib","Crizotinib","met inhibitor","case report","http://ascopubs.org/doi/full/10.1200/PO.17.00015","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP071.csv","TP071","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[129611,"B2","KDR","KDR","Q472H","Colorectal Adenocarcinoma","R961W","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",27004155,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP071.csv","TP071","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","NONE",0]
[129939,"B2","TP53","TP53","T97K","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP071.csv","TP071","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[130131,"B3","ALK","ALK","K1491R","Neuroblastoma","F1174L","sensitivity/response","AZD3463","AZD3463","igf1r inhibitor","preclinical",26786851,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP071.csv","TP071","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[130179,"B3","ALK","ALK","K1491R","lung_adeno","C1156Y (GoF)","sensitivity","Lorlatinib","Lorlatinib","alk inhibitor","preclinical",27401242,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP071.csv","TP071","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[130410,"B3","TP53","TP53","T256K","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP071.csv","TP071","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1]
[130573,"R1(OncoKB)","ALK","ALK","K1491R","Non-Small Cell Lung Cancer","C1156Y, G1269A, L1196M","resistance","Crizotinib","Crizotinib","met inhibitor","unspecified","20979473, 22235099, 23434628, 24675041, 26144315, 26698910, 27045755, 22235099, 23344087, 23434628, 24675041, 27045755, 28434515, 22235099, 22277784, 23344087, 23434628, 24675041, 27432227, 28434515","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP071.csv","TP071","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[131459,"B2","BRCA1","BRCA1","P824L","Prostate Cancer","(LoF)","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP073.csv","TP073","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[132441,"B2","BRCA1","BRCA1","P824L","Peritoneal Serous Carcinoma","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP073.csv","TP073","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[133957,"B2","BRCA1","BRCA1","E991G","breast","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","20609467, 25366685","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP073.csv","TP073","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[134766,"B2","FLT3","FLT3","D7G","Acute Myeloid Leukemia","TKD any mut., D835","resistance","Sorafenib","Sorafenib","multi TKI","clin. trials","22368270, 18230792","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP073.csv","TP073","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0,"x"]
[134838,"B2","PIK3CA","PIK3CA","I391M","Colorectal Cancer","E542K","resistance","Regorafenib","Regorafenib","multi TKI","clin. trials",26184520,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP073.csv","TP073","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","NONE",0]
[134954,"B3","ATM","ATM","G3051V","Chronic Lymphocytic Leukemia","T2666A, any mut., R3008C, c.902-1G>T, c.7089+1del, c.7515+1-2del, K293*, F1025L, D1930V, E2187*, L2427P, F2732V, K468FS, D1682H, A2062V, C2488Y","resistance","Doxorubicin","Doxorubicin","anthracyclin","preclinical",23585524,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP073.csv","TP073","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0,"x"]
[134960,"B3","ATM","ATM","G3051V","glioma","any variant (LoF)","sensitivity","Temozolomide","Temozolomide","alkylating agent","preclinical",23960094,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP073.csv","TP073","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0,"x"]
[135406,"B3","SMO","SMO","A401V","Basal Cell Carcinoma","D473H, L412F","resistance","Vismodegib","Vismodegib","hedgehog inhibitor","preclinical",25759020,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP073.csv","TP073","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[136026,"B1","BRCA1","BRCA1","P824L","Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","approved",19553641,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP074.csv","TP074","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[137414,"B2","BRCA1","BRCA1","P824L","Ovarian Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","23346317, 21862407","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP074.csv","TP074","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[138467,"B2","BRCA1","BRCA1","S509G","Breast Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP074.csv","TP074","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[139647,"B3","ATM","ATM","P1054R","glioma","any variant (LoF)","sensitivity","Temozolomide","Temozolomide","alkylating agent","preclinical",23960094,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP074.csv","TP074","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","NONE",0,"x"]
[219827,"B1","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Ceritinib","Ceritinib","alk inhibitor","approved",28602779,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_KIJK.csv","KIJK","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[140105,"B2","ATM","ATM","F858L","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP076.csv","TP076","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'tolerated', 'Score': '0.07', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Damaging","tolerated","0.07","neutral","NONE",0,"x"]
[140178,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","case report",27371698,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP076.csv","TP076","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[140278,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","V654A, Exon 9 any mut., V569-L576DEL","sensitivity/response","Sunitinib","Sunitinib","multi TKI","clin. trials","16638875, 22439647, 18955458, 26772734","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP076.csv","TP076","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[140344,"B3","ALK","ALK","K1491R","Neuroblastoma","F1174L","sensitivity/response","Alectinib","Alectinib","alk inhibitor","preclinical",21575866,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP076.csv","TP076","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[140440,"B3","EZH2","EZH2","D176H","Skin Melanoma","Y646","sensitivity/response","GSK126","GSK126","ezh2 inhibitor","preclinical",26304929,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP076.csv","TP076","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1]
[140655,"B3","KIT","KIT","M537L","acute_myeloid_leukemia","exon 8 p.416-422 (GoF)","sensitivity","Imatinib","Imatinib","kit inhibitor","preclinical",15618474,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP076.csv","TP076","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[140896,"B2","ALK","ALK","K1491R","lung_adeno","L1198F (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",26698910,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP079.csv","TP079","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[141401,"B2","BRCA1","BRCA1","P824L","breast","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","early trials",25847936,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP079.csv","TP079","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[141612,"B3","ALK","ALK","K1491R","Inflammatory Myofibroblastic Tumor","F1174L","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical",21030459,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP079.csv","TP079","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[141823,"B3","NF1","NF1","V1453F","Malignant Peripheral Nerve Sheath Tumor","loss","sensitivity/response","JQ1 Compound","JQ1 Compound","bet inhibitor","preclinical",24373973,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP079.csv","TP079","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Uncertain_significance",-1]
[141869,"R1(OncoKB)","ALK","ALK","K1491R","Non-Small Cell Lung Cancer","C1156Y, G1269A, L1196M","resistance","Crizotinib","Crizotinib","alk inhibitor","unspecified","20979473, 22235099, 23434628, 24675041, 26144315, 26698910, 27045755, 22235099, 23344087, 23434628, 24675041, 27045755, 28434515, 22235099, 22277784, 23344087, 23434628, 24675041, 27432227, 28434515","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP079.csv","TP079","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[143730,"B2","BRCA1","BRCA1","S1566G","Ovarian Cancer","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP081.csv","TP081","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[144718,"B2","BRCA1","BRCA1","P824L","Ovarian Carcinoma","any mut.","sensitivity/response","Platinum Compound","Platinum Compound","platinum","clin. trials",24240112,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP081.csv","TP081","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[146055,"B2","FGFR3","FGFR3","F386L","bladder","any variant (GoF)","response","FGFR Inhibitors","FGFR Inhibitors","fgfr inhibitor","early trials",27870574,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP081.csv","TP081","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1,"x"]
[146086,"B3","ALK","ALK","V476A","Neuroblastoma","exon 4-11 del.","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","preclinical",27049722,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP081.csv","TP081","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[146484,"B3","FLT3","FLT3","D7G","Acute Myeloid Leukemia","F691L","resistance","Midostaurin","Midostaurin","multi TKI","preclinical",22858906,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP081.csv","TP081","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0]
[146490,"B3","FLT3","FLT3","D7G","Acute Myeloid Leukemia","Y842C","resistance","Sunitinib","Sunitinib","multi TKI","preclinical",22858906,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP081.csv","TP081","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","NONE",0]
[147336,"B1","IDH2","IDH2","D225N","Acute Myeloid Leukemia","any mut.","sensitivity/response","Enasidenib","Enasidenib","idh2 inhibitor","approved",28588020,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP084.csv","TP084","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.0004","x"]
[149569,"B2","BRCA1","BRCA1","S1566G","Breast Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP084.csv","TP084","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[149869,"B2","BRCA1","BRCA1","S1566G","breast","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","20609467, 25366685","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP084.csv","TP084","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[150782,"B2","KDR","KDR","V297I","Colorectal Adenocarcinoma","R961W","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",27004155,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP084.csv","TP084","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","NONE",0]
[150850,"B2","PIK3CA","PIK3CA","I391M","Her2-receptor Positive Breast Cancer","any mut.","resistance","Trastuzumab Emtansine","Trastuzumab Emtansine","her2 inhibitor","clin. trials",26920887,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP084.csv","TP084","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","NONE",0,"x"]
[151223,"B3","ESR1","ESR1","S343L","Breast Cancer","L536Q, D538G, Y537C, Y537N, Y537S","resistance","Hormone Therapy","Hormone Therapy","anti-estrogen","preclinical",24185512,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP084.csv","TP084","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1]
[151339,"B3","PIK3CA","PIK3CA","I391M","Head And Neck Cancer","any mut., H1047R","sensitivity/response","Dactolisib","Dactolisib","mtor inhibitor","preclinical","23619167, 25855885","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP084.csv","TP084","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","NONE",0,"x"]
[151570,"B2","ALK","ALK","K1491R","Neuroblastoma","F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","case report",23598171,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t1.csv","TP092t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[152030,"B2","BRCA1","BRCA1","P824L","Ovarian Cancer","any mut.","sensitivity/response","Rucaparib","Rucaparib","parp inhibitor","clin. trials",27908594,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t1.csv","TP092t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[152156,"B2","BRCA1","BRCA1","E991G","breast","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","early trials",25847936,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t1.csv","TP092t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[152351,"B3","ALK","ALK","K1491R","Neuroblastoma","F1174L, F1245C, R1275Q","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","preclinical",26554404,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t1.csv","TP092t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[152387,"B3","ALK","ALK","K1491R","acute_lymphocytic_leukemia","F856S (GoF), A348D (GoF)","sensitivity","Crizotinib","Crizotinib","met inhibitor","preclinical",26032424,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t1.csv","TP092t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[152712,"B1","BRCA1","BRCA1","P824L","Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","approved",19553641,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t2.csv","TP092t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[152844,"B2","ALK","ALK","D1529E","lung_adeno","L1198F (GoF)","resistance","Lorlatinib","Lorlatinib","ros inhibitor","case report",26698910,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t2.csv","TP092t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[152918,"B2","BRAF","BRAF","V600E","Melanoma","L597R, V600K","sensitivity/response","Vemurafenib","Vemurafenib","raf inhibitor","case report","23715574, 26989536","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t2.csv","TP092t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[153018,"B2","BRAF","BRAF","V600E","Langerhans Cell Sarcoma","V600E","sensitivity/response","Vemurafenib","Vemurafenib","raf inhibitor","clin. trials",31513482,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t2.csv","TP092t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[153270,"B2","BRCA1","BRCA1","P824L","Peritoneal Serous Carcinoma","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t2.csv","TP092t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[153663,"B3","ALK","ALK","K1491R","Neuroblastoma","F1174L","sensitivity/response","AZD3463","AZD3463","alk inhibitor","preclinical",26786851,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t2.csv","TP092t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[153707,"B3","ALK","ALK","D1529E","Neuroblastoma","F1174L, R1275Q","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical","21948233, 22072639","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t2.csv","TP092t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[153843,"B3","BRAF","BRAF","V600E","melanoma","V600E (GoF)","sensitivity","ERK Inhibitors","ERK Inhibitors","erk inhibitor","preclinical","23614898, 22997239","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP092t2.csv","TP092t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[154797,"B2","ALK","ALK","K1491R","lung_adeno","L1196M (GoF), E1408V (GoF)","response","Brigatinib","Brigatinib","egfr inhibitor","case report","ASCO 2017 (abstr 9065)","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t1.csv","TP093t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[155748,"B2","BRCA1","BRCA1","E991G","Ovarian Cancer","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t1.csv","TP093t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[155971,"B2","BRCA1","BRCA1","S1634G","Ovarian Cancer","(LoF), any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","23346317, 21862407","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t1.csv","TP093t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[157328,"B2","BRCA1","BRCA1","S1566G","breast","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","20609467, 25366685","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t1.csv","TP093t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[158170,"B3","ALK","ALK","D1529E","glioma","F1174L (GoF)","reduced sensitivity","Crizotinib","Crizotinib","alk inhibitor","preclinical",22072639,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t1.csv","TP093t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[158198,"B3","BRCA1","BRCA1","P824L","Endometrioid Ovary Carcinoma","W1815X","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",23415752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t1.csv","TP093t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[159491,"B2","BRCA1","BRCA1","S1634G","pancreatic","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","case report","25366685, 25719666","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t2.csv","TP093t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[161592,"B2","BRCA1","BRCA1","K1136R","Breast Cancer","(LoF)","sensitivity/response","Talazoparib","Talazoparib","parp inhibitor","clin. trials",28242752,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t2.csv","TP093t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",0]
[161891,"B2","BRCA1","BRCA1","S1634G","breast","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials","20609467, 25366685","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t2.csv","TP093t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[162748,"B3","ALK","ALK","D1529E","Neuroblastoma","F1174L","sensitivity/response","AZD3463","AZD3463","alk inhibitor","preclinical",26786851,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t2.csv","TP093t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[162793,"B3","ALK","ALK","K1491R","glioma","R1275Q (GoF), G1128A (GoF), I1171N (GoF), R1192P (GoF), F1245C (GoF)","sensitivity","Crizotinib","Crizotinib","met inhibitor","preclinical",22072639,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP093t2.csv","TP093t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[163345,"B1","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 17 any mut.s","sensitivity/response","Regorafenib","Regorafenib","multi TKI","approved",23177515,"OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t1.csv","TP094t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[163408,"B2","ATM","ATM","L1238X","prostate","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",26510020,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t1.csv","TP094t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[163965,"B2","BRCA2","BRCA2","N372H","breast","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","early trials",20609467,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t1.csv","TP094t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","NONE",0,"x"]
[164087,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Regorafenib","Regorafenib","multi TKI","clin. trials",22614970,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t1.csv","TP094t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[164127,"B2","KIT","KIT","M537L","melanoma","exon 17 p.788-828, exon 18 p.829-860 (GoF)","resistance","Imatinib","Imatinib","kit inhibitor","early trials","21690468, 21642685","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t1.csv","TP094t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[164309,"B3","ALK","ALK","K1491R","lung_adeno","F1174L (GoF)","sensitivity","Novel ALK Inhibiors","Novel ALK Inhibiors","alk inhibitor","preclinical",24327273,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t1.csv","TP094t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[164314,"B3","ATM","ATM","L1238X","All Solid Tumors","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","preclinical",26510020,"OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t1.csv","TP094t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[164859,"B2","ALK","ALK","D1529E","Neuroblastoma","F1245V","sensitivity/response","Entrectinib","Entrectinib","trk inhibitor","case report",28183697,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t2.csv","TP094t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[164918,"B2","BRCA1","BRCA1","P824L","pancreatic","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","case report","25366685, 25719666","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t2.csv","TP094t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[165414,"B2","BRCA1","BRCA1","P824L","ovarian","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","late trials","22406760, 22711857","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t2.csv","TP094t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[165511,"B2","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","D820Y, N822K","sensitivity/response","Regorafenib","Regorafenib","multi TKI","case report",22614970,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t2.csv","TP094t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[165554,"B2","KIT","KIT","M537L","Mastocytosis","D816","sensitivity/response","Avapritinib","Avapritinib","pdgfr inhibitor","clin. trials","29233825, 30274985","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t2.csv","TP094t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[165757,"B3","ALK","ALK","K1491R","Neuroblastoma","exon 4-11 del.","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","preclinical",27049722,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t2.csv","TP094t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[165772,"B3","ALK","ALK","D1529E","Neuroblastoma","F1174L, F1245C, R1275Q","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","preclinical",26554404,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t2.csv","TP094t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[165891,"B3","KIT","KIT","M537L","Gastrointestinal Stromal Tumor","V654A, T670I","resistance","Imatinib","Imatinib","pdgfr inhibitor","preclinical","16954519, 25239608","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP094t2.csv","TP094t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[166315,"B2","BRCA1","BRCA1","E991G","pancreatic","any variant (LoF)","response","PARP Inhibitors","PARP Inhibitors","parp inhibitor","case report","25366685, 25719666","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP095t1.csv","TP095t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[166919,"B2","FGFR3","FGFR3","S446F","Bladder Carcinoma","any mut.","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","clin. trials",27870574,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP095t1.csv","TP095t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[167153,"B3","PTPRD","PTPRD","R995C","Head And Neck Carcinoma","any mut.","sensitivity/response","JSI-124","JSI-124","jak inhibitor","preclinical",26267899,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP095t1.csv","TP095t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'tolerated', 'Score': '0.44', 'Pipeline': 'neutral'}","PASSENGER/OTHER","Neutral","tolerated","0.44","neutral","NONE",0,"x"]
[167624,"B2","BRCA1","BRCA1","E991G","Ovarian Carcinoma","any mut.","sensitivity/response","Platinum Compound","Platinum Compound","platinum","clin. trials",24240112,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP095t2.csv","TP095t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[168144,"B3","PIK3R1","PIK3R1","M326I","glioma","any variant (LoF)","sensitivity","AKT Inhibitors","AKT Inhibitors","pi3k/akt inhibitor","preclinical",23166678,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP095t2.csv","TP095t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","None",-1,"x"]
[168867,"B1","BRCA1","BRCA1","S509G","Ovarian Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","approved",30345884,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t1.csv","TP096t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[170065,"B2","BRCA1","BRCA1","S1566G","Peritoneal Serous Carcinoma","oncogenic any mut.s","sensitivity/response","Olaparib","Olaparib","parp inhibitor","clin. trials","24882434, 25366685, 30285518, 30345884","OncoKB","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t1.csv","TP096t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[171141,"B2","BRCA1","BRCA1","E991G","Ovarian Cancer","any mut.","sensitivity/response","Rucaparib","Rucaparib","parp inhibitor","clin. trials",27908594,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t1.csv","TP096t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[172346,"B2","KIT","KIT","M537L","Melanoma","D820Y","resistance","Imatinib","Imatinib","pdgfr inhibitor","case report",21642685,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t1.csv","TP096t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[172442,"B2","KIT","KIT","M537L","Melanoma","exon 11 any mut., any mut.","sensitivity/response","Imatinib","Imatinib","kit inhibitor","clin. trials","23775962, 21690468","CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t1.csv","TP096t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[172601,"B3","ATM","ATM","G2891D","lymphoma","any variant (LoF)","sensitivity","DNA-PKc Inhibitors","DNA-PKc Inhibitors","dna-pk inhibitor","preclinical",23761041,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t1.csv","TP096t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Uncertain_significance",0,"x"]
[172957,"B3","KIT","KIT","M537L","Cancer","V560D","sensitivity/response","Imatinib Mesylate","Imatinib Mesylate","kit inhibitor","preclinical",18955458,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t1.csv","TP096t1","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[173774,"B1","BRCA1","BRCA1","S509G","Cancer","any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","approved",19553641,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t2.csv","TP096t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[174848,"B2","BRCA1","BRCA1","E991G","Triple-receptor Negative Breast Cancer","any mut.","resistance","Olaparib","Olaparib","parp inhibitor","clin. trials",21862407,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t2.csv","TP096t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[176048,"B2","BRCA1","BRCA1","E991G","Ovarian Carcinoma","any mut.","sensitivity/response","Platinum Compound","Platinum Compound","platinum","clin. trials",24240112,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t2.csv","TP096t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[177246,"B2","BRCA1","BRCA1","K1136R","ovarian","any variant (LoF)","response","Platinum Agents","Platinum Agents","platinum","late trials","22406760, 22711857","GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t2.csv","TP096t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",0,"x"]
[177409,"B2","KIT","KIT","M537L","melanoma","D820Y (GoF)","response","Imatinib","Imatinib","pdgfr inhibitor","case report",23775962,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t2.csv","TP096t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[177590,"B2","TSC1","TSC1","H732Y","bladder","any variant (LoF)","response","Everolimus","Everolimus","mtor inhibitor","early trials",22923433,"GDKD","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t2.csv","TP096t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.00368","x"]
[177940,"B3","KIT","KIT","M537L","Melanoma","L576P","sensitivity/response","Dasatinib","Dasatinib","bcr-abl inhibitor","preclinical",19671763,"CIVIC","Schrader_et_al_WES_SNV_SNV_T-PLL_TP096t2.csv","TP096t2","Patient","lymphoma","T-PLL","SNV","10.1038/s41467-017-02688-6","Schrader_et_al_18","WES",{"$nulls":5},"NONE","NONE",0]
[178254,"B1","KIT","KIT","L939V","Gastrointestinal Stromal Tumor","exon 17 any mut.s","sensitivity/response","Regorafenib","Regorafenib","multi TKI","approved",23177515,"OncoKB","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS11.csv","JS11","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[178356,"B2","KIT","KIT","L939V","Melanoma","D820Y","resistance","Imatinib","Imatinib","pdgfr inhibitor","case report",21642685,"CIVIC","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS11.csv","JS11","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1]
[178469,"B2","KIT","KIT","L935V","melanoma","D820Y (GoF)","response","Imatinib","Imatinib","kit inhibitor","case report",23775962,"GDKD","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS11.csv","JS11","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1]
[178536,"B2","KIT","KIT","L939V","Melanoma","D816, Exon 17 any mut.s, Oncogenic any mut.s, T670I, V654A","sensitivity/response","Imatinib","Imatinib","kit inhibitor","clin. trials","21642685, 23775962","OncoKB","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS11.csv","JS11","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[178629,"B2","KIT","KIT","L935V","gastrointestinal_stromal_tumor","exon 11 p.550-592 (GoF)","response","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","early trials",22898035,"GDKD","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS11.csv","JS11","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1]
[179029,"B3","KIT","KIT","L935V","Cancer","N822K","sensitivity/response","Imatinib","Imatinib","kit inhibitor","preclinical",14645423,"CIVIC","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS11.csv","JS11","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1]
[179388,"B3","KIT","KIT","L939V","acute_myeloid_leukemia","exon 8 p.416-422 (GoF)","sensitivity","Imatinib","Imatinib","pdgfr inhibitor","preclinical",15618474,"GDKD","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS11.csv","JS11","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1]
[180076,"B2","TP53","TP53","L91I","Sarcoma","deleterious any mut.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",26646755,"CIVIC","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS5.csv","JS5","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[180325,"B2","TP53","TP53","E126K","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS5.csv","JS5","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[180940,"B3","TP53","TP53","L91I","thymic_lymphoma","any variant (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS5.csv","JS5","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[181334,"B2","TP53","TP53","R116Q","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS9.csv","JS9","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[181702,"B3","TP53","TP53","R248Qc.G626A","Cancer","deleterious any mut.","resistance","Rebemadlin","Rebemadlin","mdm2/mdmx inhibitor","preclinical",17671205,"CIVIC","Song_et_al_18_targeted_SNV_ALCL_Alk+_JS9.csv","JS9","Patient","lymphoma","ALCL Alk+","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[181884,"B3","TP53","TP53","Y103X","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Song_et_al_18_targeted_SNV_ALCL_Alk-_JS13.csv","JS13","Patient","lymphoma","ALCL Alk-","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[182171,"B3","FGFR3","FGFR3","P778R","myeloma","K650 (GoF)","sensitivity","Bortezomib","Bortezomib","proteasome inhibitor","preclinical","19331127, 21273588","GDKD","Song_et_al_18_targeted_SNV_ALCL_Alk-_JS14.csv","JS14","Patient","lymphoma","ALCL Alk-","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Uncertain_significance",0]
[182268,"B2","EGFR","EGFR","K593Q","Non-Small Cell Lung Cancer","exon 20 insertion","sensitivity/response","Poziotinib","Poziotinib","her2 inhibitor","clin. trials","27188206, 29686424","OncoKB","Song_et_al_18_targeted_SNV_ALCL_Alk-_JS17.csv","JS17","Patient","lymphoma","ALCL Alk-","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[182285,"B3","EGFR","EGFR","K593Q","Colorectal Cancer","S492R, K467T","resistance","Cetuximab","Cetuximab","egfr inhibitor","preclinical",26888827,"CIVIC","Song_et_al_18_targeted_SNV_ALCL_Alk-_JS17.csv","JS17","Patient","lymphoma","ALCL Alk-","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","None",-1]
[182739,"B2","TP53","TP53","R116Q","breast","any mut. (LoF)","resistance","CDK4/CDK6 Inhibitor Abemaciclib","CDK4/CDK6 Inhibitor Abemaciclib","cdk4/6 inhibitor","early trials",27217383,"GDKD","Song_et_al_18_targeted_SNV_ALCL_Alk-_JS21.csv","JS21","Patient","lymphoma","ALCL Alk-","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[182863,"B3","TP53","TP53","R89Q","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Song_et_al_18_targeted_SNV_ALCL_Alk-_JS21.csv","JS21","Patient","lymphoma","ALCL Alk-","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[183267,"B2","ERBB2","ERBB2","Y396D","Lung Adenocarcinoma","kinase domain any mut.","sensitivity/response","Trastuzumab","Trastuzumab","her2 inhibitor","case report",26598547,"CIVIC","Song_et_al_18_targeted_SNV_CTCL_JS27.csv","JS27","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[183374,"B2","ERBB2","ERBB2","Y381D","Lung Non-small Cell Carcinoma","exon 20 insertion","sensitivity/response","Trastuzumab Deruxtecan","Trastuzumab Deruxtecan","alkaloid","clin. trials",34534430,"CIVIC","Song_et_al_18_targeted_SNV_CTCL_JS27.csv","JS27","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[183476,"B2","PTEN","PTEN","R111H","prostate","any variant (LoF)","response","PI3K Beta Inhibitor","PI3K Beta Inhibitor","pi3k/akt inhibitor","case report","ASCO 2014 (abstr 2514 )","GDKD","Song_et_al_18_targeted_SNV_CTCL_JS27.csv","JS27","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[183755,"B3","ERBB2","ERBB2","Y381D","cancer_unspecified","E321G (GoF), C334S (GoF)","sensitivity","ERBB2 TKIs","ERBB2 TKIs","her2 inhibitor","preclinical",22908275,"GDKD","Song_et_al_18_targeted_SNV_CTCL_JS27.csv","JS27","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[184047,"B3","PTEN","PTEN","R308H","Breast Cancer","loss","resistance","Alpelisib","Alpelisib","pi3k/akt inhibitor","preclinical",25409150,"CIVIC","Song_et_al_18_targeted_SNV_CTCL_JS27.csv","JS27","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Uncertain_significance",0]
[184218,"B3","PTEN","PTEN","R308H","endometrial","any variant (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical",22662154,"GDKD","Song_et_al_18_targeted_SNV_CTCL_JS27.csv","JS27","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Uncertain_significance",0,"x"]
[184337,"B3","PTEN","PTEN","R481H","Breast Cancer","loss","sensitivity/response","Pictilisib","Pictilisib","pi3k/akt inhibitor","preclinical",20453058,"CIVIC","Song_et_al_18_targeted_SNV_CTCL_JS27.csv","JS27","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[184509,"B2","EGFR","EGFR","P990S","Lung Adenocarcinoma","L858R, Exon 19 del.","sensitivity/response","Afatinib","Afatinib","egfr inhibitor","clin. trials","23816960, 22452895, 24439929, 25589191","CIVIC","Song_et_al_18_targeted_SNV_CTCL_JS28.csv","JS28","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Uncertain_significance","0.00005"]
[184551,"B2","JAK2","JAK2","R923H","Polycythemia Vera","V617F","sensitivity/response","Peginterferon Alfa-2b","Peginterferon Alfa-2b","interferon","clin. trials",16709929,"CIVIC","Song_et_al_18_targeted_SNV_CTCL_JS28.csv","JS28","Patient","lymphoma","CTCL","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None","0.00011"]
[184710,"B2","ERBB2","ERBB2","T298K","breast","V659E (GoF)","response","Lapatinib","Lapatinib","egfr inhibitor","case report",23950206,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS105.csv","JS105","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[184817,"B2","ERBB2","ERBB2","T328K","lung","A775-G776insYVMA, G776delinsVC, V659E, S310F (GoF)","response","Ado-trastuzumab Emtansine","Ado-trastuzumab Emtansine","her2 inhibitor","early trials","ASCO 2017 (abstr 8510)","GDKD","Song_et_al_18_targeted_SNV_NKTL_JS105.csv","JS105","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",0]
[185070,"B3","ERBB2","ERBB2","T298K","breast","K753E (GoF), L755S (GoF)","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical","27697991, 23220880","GDKD","Song_et_al_18_targeted_SNV_NKTL_JS105.csv","JS105","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[185374,"B2","TP53","TP53","R150W","Gastric Adenocarcinoma","any mut.","sensitivity/response","Chemotherapy","Chemotherapy",null,"clin. trials",24740294,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS109.csv","JS109","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[185695,"B3","TP53","TP53","R123W","Vulva Squamous Cell Carcinoma","R158H","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS109.csv","JS109","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[186001,"B2","TP53","TP53","C176Y","Breast Cancer","any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","case report",10786679,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS110.csv","JS110","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Pathogenic",-1,"x"]
[186369,"B3","TP53","TP53","C176Y","Vulva Squamous Cell Carcinoma","R158H","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS110.csv","JS110","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Pathogenic",-1]
[186719,"B2","TP53","TP53","H34R","Gastric Adenocarcinoma","any mut.","sensitivity/response","Chemotherapy","Chemotherapy",null,"clin. trials",24740294,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS111.csv","JS111","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Uncertain_significance","0.00011","x"]
[187006,"B3","TP53","TP53","H61R","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS111.csv","JS111","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[187164,"B2","KIT","KIT","K86N","Melanoma","S628N","sensitivity/response","Imatinib","Imatinib","kit inhibitor","case report",25317746,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS115.csv","JS115","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1]
[187183,"B2","KIT","KIT","K86N","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Imatinib","Imatinib","kit inhibitor","clin. trials",18955451,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS115.csv","JS115","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[187416,"B2","TP53","TP53","C110Y","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS115.csv","JS115","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[187530,"B2","TP53","TP53","C203Y","breast","any mut. (LoF)","resistance","CDK4/CDK6 Inhibitor Abemaciclib","CDK4/CDK6 Inhibitor Abemaciclib","cdk4/6 inhibitor","early trials",27217383,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS115.csv","JS115","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[187826,"B3","TP53","TP53","C203Y","Vulva Squamous Cell Carcinoma","R158H","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS115.csv","JS115","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[187947,"B2","ALK","ALK","R510W","inflammatory_myofibroblastic_tumor","G1128A (GoF)","resistance","Crizotinib","Crizotinib","met inhibitor","case report","http://ascopubs.org/doi/full/10.1200/PO.17.00015","GDKD","Song_et_al_18_targeted_SNV_NKTL_JS119.csv","JS119","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Likely_benign","0.00004"]
[188008,"B2","ERBB2","ERBB2","V1113I","Lung Adenocarcinoma","Kinase Domain any mut., Y772-A775DUP, G776L, G778-P780DUP","sensitivity/response","Afatinib","Afatinib","her4 inhibitor","case report","22325357, 26559459","CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS133.csv","JS133","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[188105,"B2","ERBB2","ERBB2","V1128I","breast","L869R (GoF)","response","Neratinib","Neratinib","her2 inhibitor","case report",28274957,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS133.csv","JS133","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Uncertain_significance","0.00009"]
[188440,"B3","ERBB2","ERBB2","V1113I","breast","K753E (GoF), L755S (GoF)","sensitivity","Neratinib","Neratinib","egfr inhibitor","preclinical","27697991, 23220880","GDKD","Song_et_al_18_targeted_SNV_NKTL_JS133.csv","JS133","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1]
[189216,"B2","TP53","TP53","C135F","Gastric Adenocarcinoma","any mut.","sensitivity/response","Chemotherapy","Chemotherapy",null,"clin. trials",24740294,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS134.csv","JS134","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[189702,"B2","TP53","TP53","R234C","myelodisplastic_syndrome","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS134.csv","JS134","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Pathogenic/Likely_pathogenic",-1,"x"]
[190095,"B3","TP53","TP53","R114C","Glioblastoma","M237I","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS134.csv","JS134","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[190291,"B3","TP53","TP53","R114C","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS134.csv","JS134","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[190849,"B2","TP53","TP53","I3N","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS39.csv","JS39","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[191076,"B3","TP53","TP53","I30N","Cancer","Deleterious any mut., R248Q, R248W, R175H, R273C, R273H, G245S, Y220C, V157F, R249S, R280K, R280T, R158L","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS39.csv","JS39","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Likely_benign","0.00007","x"]
[191372,"B2","MET","MET","V136I","Histiocytic And Dendritic Cell Cancer","exon 14 skipping any mut.","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25971938,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS53.csv","JS53","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.59', 'Pipeline': 'neutral'}","PASSENGER/OTHER","-","tolerated","0.59","neutral","Conflicting_interpretations_of_pathogenicity","0.00037","x"]
[191423,"B3","JAK1","JAK1","N226S","Hepatocellular Carcinoma","S703I","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical",26701727,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS59.csv","JS59","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Uncertain_significance",0]
[191501,"B2","EGFR","EGFR","S1042I","Lung Adenocarcinoma","L858R, Exon 19 del.","sensitivity/response","Afatinib","Afatinib","egfr inhibitor","clin. trials","23816960, 22452895, 24439929, 25589191","CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS62.csv","JS62","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1]
[191541,"B3","ALK","ALK","R292H","Neuroblastoma","F1174L","sensitivity/response","AZD3463","AZD3463","alk inhibitor","preclinical",26786851,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS62.csv","JS62","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.00037"]
[191551,"B3","ALK","ALK","R292H","acute_lymphocytic_leukemia","F856S (GoF), A348D (GoF)","sensitivity","Crizotinib","Crizotinib","alk inhibitor","preclinical",26032424,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS62.csv","JS62","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.00037"]
[191704,"B2","TP53","TP53","G113D","Stomach Carcinoma","R175H, R282L, R213P","sensitivity/response","EAP Protocol","EAP Protocol",null,"case report",14514923,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS67.csv","JS67","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[192145,"B3","TP53","TP53","G86D","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS67.csv","JS67","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[192402,"B2","FGFR2","FGFR2","R332C","Cholangiocarcinoma","any mut., fusion","sensitivity/response","Infigratinib","Infigratinib","fgfr inhibitor","case report",27870574,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS71.csv","JS71","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}",null,"-","deleterious","-0.93","deleterious","NONE",0,"x"]
[192799,"B3","FGFR2","FGFR2","R422C","Endometrial Cancer","N550K","sensitivity/response","PD173074","PD173074","fgfr inhibitor","preclinical",18757403,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS71.csv","JS71","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.93', 'Pipeline': 'deleterious'}",null,"-","deleterious","-0.93","deleterious","NONE",0]
[193050,"B2","FGFR2","FGFR2","R336Q","Head And Neck Squamous Cell Carcinoma","P253R","sensitivity/response","Pazopanib","Pazopanib","multi TKI","case report",23786770,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS74.csv","JS74","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","NONE",0]
[193408,"B3","FGFR2","FGFR2","R313Q","Endometrial Cancer","N550K","sensitivity/response","PD173074","PD173074","vegf inhibitor","preclinical",18757403,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS74.csv","JS74","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': '', 'Missense3D': '-', 'SIFT': 'tolerated', 'Score': '0.46', 'Pipeline': 'neutral'}",null,"-","tolerated","0.46","neutral","None",-1]
[193850,"B2","TP53","TP53","E141K","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS75.csv","JS75","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[194008,"B2","TP53","TP53","E48K","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS75.csv","JS75","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[194451,"B2","TP53","TP53","F134V","Sarcoma","deleterious any mut.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",26646755,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS76.csv","JS76","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[194585,"B3","TP53","TP53","F95V","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS76.csv","JS76","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[194694,"B2","KIT","KIT","D131N","Gastrointestinal Stromal Tumor","exon 9 any mut.","reduced sensitivity","Imatinib","Imatinib","kit inhibitor","clin. trials",18955451,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS78.csv","JS78","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[194704,"B2","KIT","KIT","D131N","Gastrointestinal Stromal Tumor","exon 17 any mut.s","sensitivity/response","Sorafenib","Sorafenib","multi TKI","clin. trials","22270258, 23140824","OncoKB","Song_et_al_18_targeted_SNV_NKTL_JS78.csv","JS78","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[194735,"B2","PDGFRA","PDGFRA","V484M","Gastrointestinal Stromal Tumor","D842V","resistance","Imatinib","Imatinib","pdgfr inhibitor","clin. trials","15928335, 16954519, 26130666","CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS83.csv","JS83","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.00011"]
[195868,"B2","TP53","TP53","S307P","germ-cell tumor","any mut. (LoF)","resistance","Cisplatin","Cisplatin","platinum","early trials",27646943,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS83.csv","JS83","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[195964,"B2","TP53","TP53","S187P","myelodisplastic_syndrome","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Song_et_al_18_targeted_SNV_NKTL_JS83.csv","JS83","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[196521,"B3","TP53","TP53","C135F","Cancer","deleterious any mut.","resistance","Rebemadlin","Rebemadlin","mdm2/mdmx inhibitor","preclinical",17671205,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS83.csv","JS83","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[196814,"B2","ALK","ALK","R291C","Neuroblastoma","F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","case report",23598171,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS84.csv","JS84","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Uncertain_significance",0]
[196855,"B3","PDGFRA","PDGFRA","T474M","Gastrointestinal Stromal Tumor","D842V","resistance","Imatinib","Imatinib","bcr-abl inhibitor","preclinical",12949711,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS85.csv","JS85","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Uncertain_significance","0.00007"]
[196977,"B2","PTEN","PTEN","H291R","Cancer","loss","sensitivity/response","Everolimus","Everolimus","mtor inhibitor","clin. trials",28330462,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS92.csv","JS92","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[197196,"B3","PTEN","PTEN","H118R","Breast Cancer","loss","sensitivity/response","PI3Kbeta Inhibitor AZD8186","PI3Kbeta Inhibitor AZD8186","pi3k/akt inhibitor","preclinical",25398829,"CIVIC","Song_et_al_18_targeted_SNV_NKTL_JS92.csv","JS92","Patient","lymphoma","NKT","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Uncertain_significance",-1]
[197269,"B3","ALK","ALK","S737L","Neuroblastoma","F1174L, R1275Q","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical","21948233, 22072639","CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS137.csv","JS137","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Likely_benign","0.00006"]
[197462,"B2","TP53","TP53","A138V","breast","any mut. (LoF)","resistance","CDK4/CDK6 Inhibitor Abemaciclib","CDK4/CDK6 Inhibitor Abemaciclib","cdk4/6 inhibitor","early trials",27217383,"GDKD","Song_et_al_18_targeted_SNV_PTCL_NOS_JS139.csv","JS139","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[197690,"B2","TP53","TP53","F209S","Stomach Carcinoma","R175H, R282L, R213P","sensitivity/response","EAP Protocol","EAP Protocol",null,"case report",14514923,"CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS141.csv","JS141","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1]
[197916,"B2","TP53","TP53","F302S","Breast Cancer","R249","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","clin. trials",9569050,"CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS141.csv","JS141","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[198253,"B3","TP53","TP53","F341S","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Song_et_al_18_targeted_SNV_PTCL_NOS_JS141.csv","JS141","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[198795,"B3","TP53","TP53","G113D","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS142.csv","JS142","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[199213,"B2","TP53","TP53","I156T","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS146.csv","JS146","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[199406,"B2","TP53","TP53","I195T","myelodisplastic_syndrome","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Song_et_al_18_targeted_SNV_PTCL_NOS_JS146.csv","JS146","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Pathogenic",0,"x"]
[199693,"B3","FLT3","FLT3","N289T","Acute Myeloid Leukemia","Y842C","resistance","FLT3/ABL/Aurora Kinase Inhibitor KW-2449","FLT3/ABL/Aurora Kinase Inhibitor KW-2449","aurk inhibitor","preclinical",22858906,"CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS147.csv","JS147","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[199720,"B2","PDGFRA","PDGFRA","R487C","hypereosinophilic_syndrome","T674I (GoF)","resistance","Imatinib","Imatinib","pdgfr inhibitor","case report",12660384,"GDKD","Song_et_al_18_targeted_SNV_PTCL_NOS_JS148.csv","JS148","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","Uncertain_significance","0.00005"]
[199829,"B2","JAK2","JAK2","P823A","Childhood B-cell Acute Lymphoblastic Leukemia","F694L","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","case report",27860260,"CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS159.csv","JS159","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",0]
[200107,"B2","TP53","TP53","E258D","Sarcoma","deleterious any mut.","sensitivity/response","Pazopanib","Pazopanib","multi TKI","clin. trials",26646755,"CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS159.csv","JS159","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[200430,"B3","TP53","TP53","E258D","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Song_et_al_18_targeted_SNV_PTCL_NOS_JS159.csv","JS159","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[200641,"B2","TP53","TP53","Q126X","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Song_et_al_18_targeted_SNV_PTCL_NOS_JS160.csv","JS160","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[200857,"B3","TP53","TP53","Q33X","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Song_et_al_18_targeted_SNV_PTCL_NOS_JS160.csv","JS160","Patient","lymphoma","NOS","SNV","10.1182/blood-2018-01-829424","Song_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[200999,"B2","TP53","TP53","M237I","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_121.csv",121,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","Likely_pathogenic",-1,"x"]
[201055,"B3","TP53","TP53","L130F","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_14.csv",14,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","Uncertain_significance",-1]
[201099,"B3","RB1","RB1","A18S","retinoblastoma","any variant (LoF)","sensitivity","MDM2/MDMX Inhibitors","MDM2/MDMX Inhibitors","mdm2/mdmx inhibitor","preclinical","17080083, 21515735","GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_18.csv",18,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Benign","0.00085","x"]
[201183,"B2","TP53","TP53","Q100*","germ-cell tumor","any mut. (LoF)","resistance","Cisplatin","Cisplatin","platinum","early trials",27646943,"GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_53.csv",53,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","NONE",0,"x"]
[201330,"B2","NRAS","NRAS","K117Q","Melanoma","any mut.","resistance","MEK Inhibitor RO4987655","MEK Inhibitor RO4987655","mek inhibitor","case report",24947927,"CIVIC","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_62.csv",62,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","None",-1,"x"]
[201391,"B3","KRAS","KRAS","G13D","lung","any variant (GoF)","sensitivity","HSP90 Inhibitors (in Combination)","HSP90 Inhibitors","hsp90 inhibitor","preclinical","23012248, 21907929","GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_62.csv",62,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0,"x"]
[201455,"B3","NRAS","NRAS","K117Q","acute_lymphocytic_leukemia","any variant (GoF)","sensitivity","MEK Inhibitors","MEK Inhibitors","mek inhibitor","preclinical",18701506,"GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_62.csv",62,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","None",-1,"x"]
[201556,"B2","ATM","ATM","A749T","Prostate Cancer","S2289*, N2875H, any mut.","sensitivity/response","Olaparib","Olaparib","parp inhibitor","case report",26510020,"CIVIC","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_73.csv",73,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[201635,"B2","KRAS","KRAS","G13D","Lung Adenocarcinoma","any mut.","sensitivity/response","Salirasib","Salirasib","ras inhibitor","clin. trials",21847063,"CIVIC","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_73.csv",73,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0,"x"]
[201813,"B3","NF1","NF1","E230K","glioma","any variant (LoF)","sensitivity","MTOR Inhibitors","MTOR Inhibitors","mtor inhibitor","preclinical",19573811,"GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_77.csv",77,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","None",-1,"x"]
[201828,"B3","PTEN","PTEN","Y174N","Ovarian Cancer","loss","resistance","Cisplatin","Cisplatin","platinum","preclinical",15790433,"CIVIC","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_77.csv",77,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","Likely_pathogenic",-1]
[201982,"B2","KRAS","KRAS","G13D","Colorectal Cancer","any mut.","sensitivity/response","MEK Inhibitor RO4987655","MEK Inhibitor RO4987655","mek inhibitor","clin. trials",24947927,"CIVIC","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_7.csv",7,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0,"x"]
[202049,"B3","KRAS","KRAS","G13D","lung","any variant (GoF)","sensitivity","JAK/TBK1/ikk Inhibitor","JAK/TBK1/ikk Inhibitor",null,"preclinical",24444711,"GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_7.csv",7,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Conflicting_interpretations_of_pathogenicity",0,"x"]
[202178,"B3","ARID1A","ARID1A","G36A","ovarian","any variant (LoF)","sensitivity","EZH2 Inhibitor","EZH2 Inhibitor","ezh2 inhibitor","preclinical",25686104,"GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_96.csv",96,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","None",-1,"x"]
[202215,"B2","ARID1A","ARID1A","G36A","breast cancer","any mut. (LoF)","resistance","Trastuzumab (ANXA1 High)","Trastuzumab","her2 inhibitor","early trials",27172896,"GDKD","Ungewickel_15_WES+RNA_mutations_SNV_CTCL_99.csv",99,"Patient","lymphoma","CTCL","SNV","10.1038/ng.3370","Ungewickell_et_al_15","WES + RNA seq",{"$nulls":5},"NONE","None",-1,"x"]
[202408,"B2","PTEN","PTEN","R303X","melanoma","any variant (LoF)","resistance","BRAF Inhibitors In BRAF Mutant Tumor","BRAF Inhibitors In BRAF Mutant Tumor","raf inhibitor","early trials","http://ascopubs.org/doi/abs/10.1200/PO.16.00054","GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_AITL_AITL002.csv","AITL002","Patient","lymphoma","AITL","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[202584,"B3","PTEN","PTEN","R303X","Breast Cancer","loss","sensitivity/response","PI3Kbeta Inhibitor AZD8186","PI3Kbeta Inhibitor AZD8186","pi3k/akt inhibitor","preclinical",25398829,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_AITL_AITL002.csv","AITL002","Patient","lymphoma","AITL","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[202611,"B3","PTEN","PTEN","R130XR303X","Prostate Cancer","loss","sensitivity/response","Temsirolimus","Temsirolimus","mtor inhibitor","preclinical",11504908,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_AITL_AITL002.csv","AITL002","Patient","lymphoma","AITL","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[202787,"B3","IDH2","IDH2","R172S","Acute Myeloid Leukemia","any mut.","sensitivity/response","Enasidenib","Enasidenib","idh2 inhibitor","preclinical",28193778,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_AITL_AITL010.csv","AITL010","Patient","lymphoma","AITL","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","None",-1,"x"]
[202889,"B1","DNMT3A","DNMT3A","R693C","acute_myeloid_leukemia","any variant (LoF)","response","Daunorubicin","Daunorubicin","anthracyclin","FDA-approved",22417203,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_AITL_AITL015.csv","AITL015","Patient","lymphoma","AITL","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[203276,"B2","TP53","TP53","P119S","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL004.csv","PTCL004","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[203436,"B3","TP53","TP53","P119S","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL004.csv","PTCL004","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[203880,"B2","TP53","TP53","Q60X","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL005.csv","PTCL005","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[204111,"B2","EZH2","EZH2","N143K","Diffuse Large B-cell Lymphoma","Y646H","sensitivity/response","Tazemetostat","Tazemetostat","ezh2 inhibitor","case report",29650362,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL006.csv","PTCL006","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[204450,"B2","TP53","TP53","R37Q","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL008.csv","PTCL008","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[204660,"B3","TP53","TP53","R196Q","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL008.csv","PTCL008","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","Uncertain_significance",0]
[204834,"B2","DNMT3A","DNMT3A","Q402X","Acute Myeloid Leukemia","any mut.","sensitivity/response","Decitabine","Decitabine","demethylating agent","clin. trials",22124213,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL011.csv","PTCL011","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[205272,"B2","TP53","TP53","A161D","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL016.csv","PTCL016","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity",-1,"x"]
[205397,"B3","TP53","TP53","A29D","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL016.csv","PTCL016","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","Likely_benign",-1,"x"]
[205779,"B2","ARID1A","ARID1A","G655X","breast cancer","any mut. (LoF)","resistance","Trastuzumab (ANXA1 High)","Trastuzumab","her2 inhibitor","early trials",27172896,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL024.csv","PTCL024","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[205835,"B2","DNMT3A","DNMT3A","Q816X","Acute Myeloid Leukemia","any mut.","sensitivity/response","Decitabine","Decitabine","demethylating agent","clin. trials",22124213,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL030.csv","PTCL030","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[206581,"B2","TP53","TP53","S260C122-125del95-98del215-218del254-257del","germ-cell tumor","any mut. (LoF)","resistance","Cisplatin","Cisplatin","platinum","early trials",27646943,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL030.csv","PTCL030","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[207157,"B3","TP53","TP53","S260C122-125del95-98del215-218del254-257del","thymic_lymphoma","any variant (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL030.csv","PTCL030","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[207264,"B3","IDH2","IDH2","R120G","Acute Myeloid Leukemia","any mut.","sensitivity/response","Enasidenib","Enasidenib","idh2 inhibitor","preclinical",28193778,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL034.csv","PTCL034","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[207393,"B3","PTEN","PTEN","R52fsR52fs","breast","any variant (lof) (LoF)","sensitivity","PI3K Pathway Inhibitors","PI3K Pathway Inhibitors","pi3k/akt inhibitor","preclinical","23085766, 22932669","GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL042.csv","PTCL042","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[207839,"B3","TP53","TP53","Y234C","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL043.csv","PTCL043","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","Pathogenic/Likely_pathogenic",-1,"x"]
[207981,"B3","TP53","TP53","Y75C","Vulva Squamous Cell Carcinoma","R158H","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL043.csv","PTCL043","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[208271,"B2","ALK","ALK","Q594X","Neuroblastoma","F1245C","resistance","Crizotinib","Crizotinib","alk inhibitor","case report",23598171,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL060.csv","PTCL060","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[208275,"B2","ALK","ALK","Q594X","inflammatory_myofibroblastic_tumor","G1128A (GoF)","resistance","Crizotinib","Crizotinib","met inhibitor","case report","http://ascopubs.org/doi/full/10.1200/PO.17.00015","GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL060.csv","PTCL060","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[208448,"B3","TP53","TP53","N213fsN186fsN306fsN345fs","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL065.csv","PTCL065","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[208460,"B3","TP53","TP53","N213fsN186fsN306fsN345fs","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL065.csv","PTCL065","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[208595,"B3","IDH2","IDH2","R172K","Acute Myeloid Leukemia","any mut.","sensitivity/response","Enasidenib","Enasidenib","idh2 inhibitor","preclinical",28193778,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL070.csv","PTCL070","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","Pathogenic/Likely_pathogenic|_risk_factor",-1,"x"]
[209631,"B3","TP53","TP53","Q35fsQ8fsQ128fsQ167fsP45S","Breast Cancer","R175H, any mut.","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","preclinical",22698404,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL074.csv","PTCL074","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[209875,"B3","TP53","TP53","P177S","head_neck","any variant (lof) (lof) (lof) (lof) (lof) (lof) (lof) (lof) (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL074.csv","PTCL074","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[210225,"B2","DNMT3A","DNMT3A","I695T","Acute Myeloid Leukemia","any mut.","sensitivity/response","Decitabine","Decitabine","demethylating agent","clin. trials",22124213,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL080.csv","PTCL080","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","None",-1,"x"]
[210939,"B2","TP53","TP53","E248D","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL087.csv","PTCL087","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[211291,"B2","TP53","TP53","K93R","Breast Cancer","dna binding domain any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","clin. trials",10786679,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL087.csv","PTCL087","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[212601,"B3","TP53","TP53","R24fsR24fsR117fsR117fsR156fsR156fsE155D","thymic_lymphoma","any variant (lof) (lof) (lof) (lof) (lof) (lof) (lof) (lof) (lof) (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL087.csv","PTCL087","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[212604,"B3","TP53","TP53","E248D","thymic_lymphoma","any variant (lof) (lof) (lof) (lof) (lof) (lof) (lof) (lof) (lof) (LoF)","sensitivity","Pramlintide","Pramlintide",null,"preclinical",25409149,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL087.csv","PTCL087","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[212814,"B2","TP53","TP53","P20fsP20fsP113fsP113fsP152fsP152fs","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL101.csv","PTCL101","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[212945,"B3","JAK3","JAK3","Q501H","lymphoma","A572V, A573V","sensitivity","JAK Inhibitors","JAK Inhibitors","jak inhibitor","preclinical",22705984,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL107.csv","PTCL107","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","Uncertain_significance",0]
[213316,"B3","TP53","TP53","E48delinsDE","head_neck","any variant (lof) (lof) (lof) (lof) (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL110.csv","PTCL110","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[213604,"B2","TP53","TP53","M27I","Lung Non-small Cell Carcinoma","deleterious any mut., wildtype","sensitivity/response","Adjuvant Chemotherapy","Adjuvant Chemotherapy",null,"clin. trials",26899019,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL111.csv","PTCL111","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[213990,"B3","TP53","TP53","W52X","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL111.csv","PTCL111","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[214077,"B2","ALK","ALK","W444C","lung_adeno","L1196M (GoF), L1152R (GoF), C1156Y (GoF), F1174L (GoF), G1202R (GoF), S1206Y (GoF), G1269A (GoF)","resistance","Crizotinib","Crizotinib","met inhibitor","case report",22277784,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL112.csv","PTCL112","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1]
[214324,"B3","ALK","ALK","W444C","Neuroblastoma","F1174L, R1275Q","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical","21948233, 22072639","CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL112.csv","PTCL112","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1]
[214501,"B2","TP53","TP53","H46fsH19fsH139fsH178fs","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL113.csv","PTCL113","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0,"x"]
[214716,"B2","TP53","TP53","P113L","Breast Cancer","any mut.","resistance","Tamoxifen","Tamoxifen","anti-estrogen","case report",10786679,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL116.csv","PTCL116","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","None",-1,"x"]
[214940,"B3","TP53","TP53","P20L","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL116.csv","PTCL116","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1,"x"]
[215061,"B2","TP53","TP53","V274F","Stomach Carcinoma","R175H, R282L, R213P","sensitivity/response","EAP Protocol","EAP Protocol",null,"case report",14514923,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL120.csv","PTCL120","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","Uncertain_significance",-1]
[215540,"B3","TP53","TP53","V142F","cancer_unspecified","R248Q, R175H (GoF)","sensitivity","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","preclinical",26009011,"GDKD","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL120.csv","PTCL120","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[215709,"B2","MYD88","MYD88","Y244H","Waldenstroem's Macroglobulinemia","L265P","sensitivity/response","Ibrutinib","Ibrutinib","btk inhibitor","clin. trials",25853747,"CIVIC","Watatani_et_al_19_Somatic_mut_targeted_SNV_PTCL_NOS_PTCL121.csv","PTCL121","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","Targeted",{"$nulls":5},"NONE","NONE",0]
[215858,"B1","IDH2","IDH2","R42K","Acute Myeloid Leukemia","any mut.","sensitivity/response","Enasidenib","Enasidenib","idh2 inhibitor","approved",28588020,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_AITL_35T.csv","35T","Patient","lymphoma","AITL","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","None",-1,"x"]
[215907,"B3","ALK","ALK","Q286R","Neuroblastoma","F1174L, F1245C, R1275Q","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","preclinical",26554404,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_AITL_35T.csv","35T","Patient","lymphoma","AITL","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","None",-1]
[216191,"B2","TP53","TP53","C44F","Breast Cancer","R249","sensitivity/response","Doxorubicin","Doxorubicin","anthracyclin","clin. trials",9569050,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_ALCL_Alk+_GPS-56-57.csv","GPS-56-57","Patient","lymphoma","ALCL Alk+","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[216480,"B3","TP53","TP53","C17F","Glioblastoma","M237I","resistance","MDM2 Inhibitor AMGMDS3","MDM2 Inhibitor AMGMDS3","mdm2/mdmx inhibitor","preclinical",25730903,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_ALCL_Alk+_GPS-56-57.csv","GPS-56-57","Patient","lymphoma","ALCL Alk+","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[216780,"B2","ALK","ALK","G558R","lung_adeno","L1198F (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",26698910,"GDKD","Watatani_et_al_19_Somatic_mut_WES_SNV_ALCL_Alk-_GPS-93-94.csv","GPS-93-94","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","None",-1]
[216795,"B3","ALK","ALK","G558R","glioma","F1174L (GoF)","reduced sensitivity","Crizotinib","Crizotinib","met inhibitor","preclinical",22072639,"GDKD","Watatani_et_al_19_Somatic_mut_WES_SNV_ALCL_Alk-_GPS-93-94.csv","GPS-93-94","Patient","lymphoma","ALCL Alk-","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","None",-1]
[217101,"B2","TP53","TP53","P278S","Chronic Lymphocytic Leukemia","any mut.","sensitivity/response","Alemtuzumab","Alemtuzumab","cd52 antibody","clin. trials",14726385,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL004.csv","PTCL004","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","Conflicting_interpretations_of_pathogenicity","0.00005","x"]
[217163,"B2","TP53","TP53","P119S","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL004.csv","PTCL004","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","None",-1,"x"]
[217571,"B2","ERBB2","ERBB2","frame-shift-del","cancer_unspecified","S310, L755, V777, P780-Y781insGSP, A775-G776insYVMA (lof) (GoF)","response","Neratinib","Neratinib","her2 inhibitor","early trials","AACR 2017 (abstr CT001)","GDKD","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL005.csv","PTCL005","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[217744,"B2","PIK3CA","PIK3CA","R38H","Colorectal Cancer","E542K","resistance","Regorafenib","Regorafenib","multi TKI","clin. trials",26184520,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL005.csv","PTCL005","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Likely_pathogenic",-1]
[217899,"B2","TP53","TP53","Q60X","Leukemia","deleterious any mut.","resistance","RG7112","RG7112","mdm2/mdmx inhibitor","clin. trials",26459177,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL005.csv","PTCL005","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[218058,"B3","PIK3CA","PIK3CA","R38H","Cervical Cancer","E545K","resistance","Cisplatin","Cisplatin","platinum","preclinical",27489350,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL005.csv","PTCL005","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Damaging', 'SIFT': 'deleterious', 'Score': '-0.4', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Damaging","deleterious","-0.4","deleterious","Likely_pathogenic",-1]
[218126,"B3","TP53","TP53","Q33X","Lung Non-small Cell Carcinoma","any mut.","resistance","Docetaxel","Docetaxel","alkaloid","preclinical",22425996,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL005.csv","PTCL005","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[218397,"B2","BTK","BTK","R562Q","chronic_lymphocytic_leukemia","C481S (GoF)","resistance","Ibrutinib","Ibrutinib","btk inhibitor","early trials","24869598, 27199251","GDKD","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL008.csv","PTCL008","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","None",-1]
[218442,"B2","EGFR","EGFR","R675G","Lung Adenocarcinoma","exon 20 insertion","resistance","Afatinib","Afatinib","egfr inhibitor","clin. trials",26051236,"CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL008.csv","PTCL008","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance",-1]
[218869,"B2","TP53","TP53","R37Q","acute_myeloid_leukemia","any mut. (LoF)","response","Decitabine","Decitabine","demethylating agent","early trials",27959731,"GDKD","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL008.csv","PTCL008","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[218907,"B3","EGFR","EGFR","R675G","Cancer","L858R, W731L, Y801H, G598V","sensitivity/response","Erlotinib","Erlotinib","egfr inhibitor","preclinical","17877814, 21132006, 20942962, 17177598","CIVIC","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL008.csv","PTCL008","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': '-', 'SIFT': 'deleterious', 'Score': '-0.1', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","-","deleterious","-0.1","deleterious","Uncertain_significance",-1]
[219122,"B3","TP53","TP53","R64Q","head_neck","any variant (LoF)","sensitivity","WEE1 Inhibitors","WEE1 Inhibitors","wee1 inhibitor","preclinical",25125259,"GDKD","Watatani_et_al_19_Somatic_mut_WES_SNV_PTCL_NOS_PTCL008.csv","PTCL008","Patient","lymphoma","NOS","SNV","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[219319,"B3","IDH2","IDH2","R172S","biliary_tract","R172 (GoF)","sensitivity","Dasatinib","Dasatinib","bcr-abl inhibitor","preclinical",27231123,"GDKD","Yoo_et_al_14_SNVs_WES+RNAseq_SNV_AITL_5.csv",5,"Patient","lymphoma","AITL","SNV","10.1038/ng.2916","Yoo_et_al_14","WES + RNA seq","{'FATHMM': 'PASSENGER/OTHER', 'Missense3D': 'Neutral', 'SIFT': 'deleterious', 'Score': '-0.02', 'Pipeline': 'deleterious'}","PASSENGER/OTHER","Neutral","deleterious","-0.02","deleterious","None",-1]
[219346,"B1","ROS1",null,"NCOR2-ROS1","Lung Non-small Cell Carcinoma","fusion, rearrangement","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","approved","30980071, 29596029","CIVIC","Crescenzo_et_al_15_Fusions_RNA_Fusion_ALCL_Alk-_GPS-99.csv","GPS-99","Patient","lymphoma","ALCL Alk-","Fusion","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15",{"$nulls":6},"NONE","NONE",0,"x"]
[219408,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","clin. trials",28475456,"CIVIC","Crescenzo_et_al_15_Fusions_WES_Fusion_ALCL_Alk+_GPS-25-26.csv","GPS-25-26","Patient","lymphoma","ALCL Alk+","Fusion","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[219431,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion G1202R, ALK Fusion G1269A","resistance","Alectinib","Alectinib","alk inhibitor","preclinical",25727400,"CIVIC","Crescenzo_et_al_15_Fusions_WES_Fusion_ALCL_Alk+_GPS-25-26.csv","GPS-25-26","Patient","lymphoma","ALCL Alk+","Fusion","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[219496,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","clin. trials",28475456,"CIVIC","Crescenzo_et_al_15_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[219536,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","preclinical",26554404,"CIVIC","Crescenzo_et_al_15_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[219584,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","clin. trials",28475456,"CIVIC","Crescenzo_et_al_15_Fusions_WES_Fusion_ALCL_Alk+_GPS-74-75.csv","GPS-74-75","Patient","lymphoma","ALCL Alk+","Fusion","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[219635,"B1","ALK",null,"TRAF1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Alectinib","Alectinib","alk inhibitor","approved","26708155, 28586279, 28501140","CIVIC","Crescenzo_et_al_15_Fusions_WES_Fusion_ALCL_Alk-_GPS-56-57.csv","GPS-56-57","Patient","lymphoma","ALCL Alk-","Fusion","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[219672,"B2","ALK",null,"TRAF1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","clin. trials",28475456,"CIVIC","Crescenzo_et_al_15_Fusions_WES_Fusion_ALCL_Alk-_GPS-56-57.csv","GPS-56-57","Patient","lymphoma","ALCL Alk-","Fusion","10.1016/J.CCELL.2015.03.006","Crescenzo_et_al_15","WES",{"$nulls":5},"NONE","NONE",0]
[219724,"B1","PDGFRB",null,"CD53-PDGFRB","Myelodysplastic/Myeloproliferative Neoplasms","fusions","sensitivity/response","Imatinib","Imatinib","kit inhibitor","approved","12181402, 12676775, 14504092, 1516603, 16960151, 18950453, 22897847, 24687085, 26355392","OncoKB","Ng_et_al_2018_Supp_2_Fusion_DERL-2-1.csv","DERL-2-1","Cell line","lymphoma","HS-TCL","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[219754,"B2","ALK",null,"NPM1-ALK","Lung Adenocarcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25922291,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_KARPAS299.csv","Karpas-299","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[219828,"B1","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","approved","20979469, 23724913, 25470694","CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_KIJK.csv","KIJK","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[219845,"B2","ALK",null,"NPM1-ALK","Vagina Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",26942346,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_KIJK.csv","KIJK","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[219906,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK T1151INST, ALK Fusion G1202R","sensitivity/response","Tanespimycin","Tanespimycin","hsp90 inhibitor","preclinical",22277784,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_KIJK.csv","KIJK","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[219941,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Retaspimycin Hydrochloride","Retaspimycin Hydrochloride","hsp90 inhibitor","case report",20940188,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_SR786.csv","SR786","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220022,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK, EML4::ALK C1156Y-L1198F, EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","20979473, 26698910, 20979469","CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_SUDHL1.csv","SUDHL1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220065,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK L1196M","sensitivity/response","Alectinib","Alectinib","alk inhibitor","preclinical",21575866,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_SUDHL1.csv","SUDHL1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220113,"B2","ALK",null,"NPM1-ALK","Diffuse Large B-cell Lymphoma","fusion, cltc::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","24330038, 26221234","CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_SUPM2.csv","SUP-M2","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220138,"B2","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials",23598171,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_fh_SUPM2.csv","SUP-M2","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220205,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y, EML4::ALK L1196M, EML4::ALK T1151INST, EML4::ALK L1152R, EML4::ALK G1269A, EML4::ALK and ampl., ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","case report","20979473, 22277784, 21791641, 22235099, 23344087, 26775591","CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220228,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Alectinib","Alectinib","alk inhibitor","clin. trials","23639470, 25153538","CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220257,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion G1269A","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220257,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion G1269A","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220258,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK  V1180L","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","preclinical",25228534,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220258,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK  V1180L","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","preclinical",25228534,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220262,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical",22034911,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220262,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","preclinical",22034911,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220263,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","F1174L, EML4::ALK and ampl., ALK Fusion G1202R, EML4::ALK L1196M, EML4::ALK S1206Y, ALK Fusion I1171, EML4::ALK  V1180L, EML4::ALK C1156Y","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical","21030459, 22277784, 25228534, 24675041","CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220263,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","F1174L, EML4::ALK and ampl., ALK Fusion G1202R, EML4::ALK L1196M, EML4::ALK S1206Y, ALK Fusion I1171, EML4::ALK  V1180L, EML4::ALK C1156Y","resistance","Crizotinib","Crizotinib","met inhibitor","preclinical","21030459, 22277784, 25228534, 24675041","CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220264,"B3","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",18089725,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220264,"B3","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",18089725,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220265,"B3","ALK",null,"NPM1-ALK","Cancer","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220265,"B3","ALK",null,"NPM1-ALK","Cancer","npm::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220266,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",22912387,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220266,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",22912387,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220269,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","preclinical",26554404,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220269,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","preclinical",26554404,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220272,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK T1151INST","resistance","TAE684","TAE684","alk inhibitor","preclinical",22277784,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220273,"B3","ALK",null,"NPM1-ALK","Diffuse Large B-cell Lymphoma","cltc::alk","sensitivity/response","TAE684","TAE684","alk inhibitor","preclinical",21494621,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220274,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK e6-e20, ALK Fusion I1171, EML4::ALK  V1180L","sensitivity/response","TAE684","TAE684","alk inhibitor","preclinical","18451166, 18594010, 25228534","CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220275,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK T1151INST, ALK Fusion G1202R","sensitivity/response","Tanespimycin","Tanespimycin","hsp90 inhibitor","preclinical",22277784,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220276,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","WHI-P154","WHI-P154","egfr inhibitor","preclinical",17625570,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220276,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","WHI-P154","WHI-P154","jak inhibitor","preclinical",17625570,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_L82-1.csv","L82-1","Cell line","lymphoma","ALCL Alk+","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220277,"B2","JAK2",null,"JAK2-PCM1","B-lymphoblastic Leukemia/lymphoma, BCR-ABL1<U+2013>like","GOLGA5::JAK2, SSBP2::JAK2","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","case report","29773603, 25207766","CIVIC","Ng_et_al_2018_Supp_2_Fusion_MAC2A-1.csv","MAC2A-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220278,"B2","JAK2",null,"JAK2-PCM1","Chronic Eosinophilic Leukemia, NOS","PCM1-JAK2 Fusion","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","clin. trials","22875628, 22899477, 23400675, 23630205, 25207766, 25260694, 25515960, 26202607","OncoKB","Ng_et_al_2018_Supp_2_Fusion_MAC2A-1.csv","MAC2A-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220279,"B2","JAK2",null,"PCM1-JAK2","Chronic Eosinophilic Leukemia, NOS","PCM1-JAK2 Fusion","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","clin. trials","22875628, 22899477, 23400675, 23630205, 25207766, 25260694, 25515960, 26202607","OncoKB","Ng_et_al_2018_Supp_2_Fusion_MAC2A-1.csv","MAC2A-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220280,"B3","BCR-JAK2",null,"JAK2-PCM1","acute_lymphocytic_leukemia","rearrangement (GoF)","sensitivity","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical",22897847,"GDKD","Ng_et_al_2018_Supp_2_Fusion_MAC2A-1.csv","MAC2A-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220281,"B3","JAK2",null,"JAK2-PCM1","acute_lymphocytic_leukemia","rearrangement (GoF)","sensitivity","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical","22875628, 22899477","GDKD","Ng_et_al_2018_Supp_2_Fusion_MAC2A-1.csv","MAC2A-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220282,"B2","BRD4",null,"TRBV7-4-TRBC2","NUT_midline_carcinoma","BRD4-NUT fusion (GoF)","response","BET Inhibitors","BET Inhibitors","bet inhibitor","case report","ENA 2015 (abstract A49)","GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY12-1.csv","OCI-Ly12-1","Cell line","lymphoma","NOS","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220283,"B2","BRD4",null,"TRBV7-4-TRBC2","NUT Midline Carcinoma","BRD4::NUTM1","sensitivity/response","Birabresib","Birabresib","bet inhibitor","case report",26976114,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY12-1.csv","OCI-Ly12-1","Cell line","lymphoma","NOS","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220284,"B2","CTLA4",null,"TRBV7-4-TRBC2","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY12-1.csv","OCI-Ly12-1","Cell line","lymphoma","NOS","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220285,"B3","BRD4",null,"TRBV7-4-TRBC2","NUT Midline Carcinoma","BRD4::NUTM1","sensitivity/response","JQ1","JQ1","bet inhibitor","preclinical",20871596,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY12-1.csv","OCI-Ly12-1","Cell line","lymphoma","NOS","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220291,"B1","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Alectinib","Alectinib","alk inhibitor","approved","26708155, 28586279, 28501140","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220296,"B1","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","approved","20979469, 23724913, 25470694","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220296,"B1","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","approved","20979469, 23724913, 25470694","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220297,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","ALK Fusion I1171","resistance","Alectinib","Alectinib","alk inhibitor","case report","25228534, 25736571","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220298,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Alectinib","Alectinib","alk inhibitor","case report",26938871,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220303,"B2","ALK",null,"NPM1-ALK","Lung Adenocarcinoma","ALK Fusion G1202R","resistance","Crizotinib","Crizotinib","alk inhibitor","case report",22277784,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220303,"B2","ALK",null,"NPM1-ALK","Lung Adenocarcinoma","ALK Fusion G1202R","resistance","Crizotinib","Crizotinib","met inhibitor","case report",22277784,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220304,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y, EML4::ALK L1196M, EML4::ALK T1151INST, EML4::ALK L1152R, EML4::ALK G1269A, EML4::ALK and ampl., ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","alk inhibitor","case report","20979473, 22277784, 21791641, 22235099, 23344087, 26775591","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220304,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y, EML4::ALK L1196M, EML4::ALK T1151INST, EML4::ALK L1152R, EML4::ALK G1269A, EML4::ALK and ampl., ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","case report","20979473, 22277784, 21791641, 22235099, 23344087, 26775591","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220305,"B2","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",21345110,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220305,"B2","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",21345110,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220306,"B2","ALK",null,"NPM1-ALK","Cancer","EML4::ALK e20-e20","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25408655,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220306,"B2","ALK",null,"NPM1-ALK","Cancer","EML4::ALK e20-e20","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25408655,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220307,"B2","ALK",null,"NPM1-ALK","Diffuse Large B-cell Lymphoma","fusion, cltc::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","24330038, 26221234","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220307,"B2","ALK",null,"NPM1-ALK","Diffuse Large B-cell Lymphoma","fusion, cltc::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","24330038, 26221234","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220308,"B2","ALK",null,"NPM1-ALK","Epithelioid Inflammatory Myofibroblastic Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25028698,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220308,"B2","ALK",null,"NPM1-ALK","Epithelioid Inflammatory Myofibroblastic Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25028698,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220309,"B2","ALK",null,"NPM1-ALK","Inflammatory Myofibroblastic Tumor","RANBP2::ALK","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",20979472,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220309,"B2","ALK",null,"NPM1-ALK","Inflammatory Myofibroblastic Tumor","RANBP2::ALK","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",20979472,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220310,"B2","ALK",null,"NPM1-ALK","Lung Adenocarcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25922291,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220310,"B2","ALK",null,"NPM1-ALK","Lung Adenocarcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25922291,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220311,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK, EML4::ALK C1156Y-L1198F, EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","20979473, 26698910, 20979469","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220311,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK, EML4::ALK C1156Y-L1198F, EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","20979473, 26698910, 20979469","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220312,"B2","ALK",null,"NPM1-ALK","Thyroid Gland Anaplastic Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",24687827,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220312,"B2","ALK",null,"NPM1-ALK","Thyroid Gland Anaplastic Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",24687827,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220313,"B2","ALK",null,"NPM1-ALK","Vagina Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",26942346,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220313,"B2","ALK",null,"NPM1-ALK","Vagina Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",26942346,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220317,"B2","ALK",null,"NPM1-ALK","Colorectal Cancer","cad::alk","sensitivity/response","Entrectinib","Entrectinib","trk inhibitor","case report",26633560,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220318,"B2","ALK",null,"NPM1-ALK","Lung Acinar Adenocarcinoma","EML4::ALK","resistance","Erlotinib","Erlotinib","egfr inhibitor","case report",23181703,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220319,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y-L1198F","resistance","Lorlatinib","Lorlatinib","alk inhibitor","case report",26698910,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220319,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y-L1198F","resistance","Lorlatinib","Lorlatinib","ros inhibitor","case report",26698910,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220320,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","case report",26698910,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220320,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","case report",26698910,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220321,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Retaspimycin Hydrochloride","Retaspimycin Hydrochloride","hsp90 inhibitor","case report",20940188,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220323,"B2","ALK",null,"NPM1-ALK","inflammatory_myofibroblastic_tumor","rearrangement (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",20979472,"GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220323,"B2","ALK",null,"NPM1-ALK","inflammatory_myofibroblastic_tumor","rearrangement (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",20979472,"GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220324,"B2","ALK",null,"NPM1-ALK","thyroid","rearrangement (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",24687827,"GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220324,"B2","ALK",null,"NPM1-ALK","thyroid","rearrangement (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",24687827,"GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220327,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Alectinib","Alectinib","alk inhibitor","clin. trials","23639470, 25153538","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220328,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","clin. trials",28475456,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220328,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","clin. trials",28475456,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220332,"B2","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials",23598171,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220332,"B2","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials",23598171,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220333,"B2","ALK",null,"NPM1-ALK","Inflammatory Myofibroblastic Tumor","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials",23598171,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220333,"B2","ALK",null,"NPM1-ALK","Inflammatory Myofibroblastic Tumor","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials",23598171,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220334,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials","24478318, 27022118, 21933749, 26466010","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220334,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials","24478318, 27022118, 21933749, 26466010","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220337,"B2","ALK",null,"NPM1-ALK","Cancer","fusion","sensitivity/response","Entrectinib","Entrectinib","trk inhibitor","clin. trials",28183697,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220338,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","clin. trials",30413378,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220338,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","clin. trials",30413378,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220339,"B2","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Pemetrexed","Pemetrexed","antimetabolite","clin. trials",21642865,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220340,"B2","ALK",null,"NPM1-ALK","lung_adeno","rearrangement (GoF)","response","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","early trials",23553849,"GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220341,"B2","ALK",null,"NPM1-ALK","lymphoma","rearrangement (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","early trials",24491302,"GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220341,"B2","ALK",null,"NPM1-ALK","lymphoma","rearrangement (GoF)","response","Crizotinib","Crizotinib","met inhibitor","early trials",24491302,"GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220342,"B2","ALK",null,"NPM1-ALK","lung_adeno","rearrangement (GoF)","response","Novel ALK Inhibitors","Novel ALK Inhibitors","alk inhibitor","early trials",23639470,"GDKD","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220351,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion G1202R, ALK Fusion G1269A","resistance","Alectinib","Alectinib","alk inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220352,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK  V1180L, EML4::ALK T1151INST","resistance","Alectinib","Alectinib","alk inhibitor","preclinical","25228534, 22277784","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220353,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK L1196M","sensitivity/response","Alectinib","Alectinib","alk inhibitor","preclinical",21575866,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220354,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK e6-e20","sensitivity/response","Alvespimycin","Alvespimycin","hsp90 inhibitor","preclinical",22912387,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220355,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion G1202R","resistance","Brigatinib","Brigatinib","alk inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220355,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion G1202R","resistance","Brigatinib","Brigatinib","egfr inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220356,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion G1269A","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220356,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion G1269A","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220357,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK  V1180L","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","preclinical",25228534,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220357,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK  V1180L","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","preclinical",25228534,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220361,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical",22034911,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220361,"B3","ALK",null,"NPM1-ALK","Cancer","ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","preclinical",22034911,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220362,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","F1174L, EML4::ALK and ampl., ALK Fusion G1202R, EML4::ALK L1196M, EML4::ALK S1206Y, ALK Fusion I1171, EML4::ALK  V1180L, EML4::ALK C1156Y","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical","21030459, 22277784, 25228534, 24675041","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220362,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","F1174L, EML4::ALK and ampl., ALK Fusion G1202R, EML4::ALK L1196M, EML4::ALK S1206Y, ALK Fusion I1171, EML4::ALK  V1180L, EML4::ALK C1156Y","resistance","Crizotinib","Crizotinib","met inhibitor","preclinical","21030459, 22277784, 25228534, 24675041","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220363,"B3","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",18089725,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220363,"B3","ALK",null,"NPM1-ALK","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",18089725,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220364,"B3","ALK",null,"NPM1-ALK","Cancer","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220364,"B3","ALK",null,"NPM1-ALK","Cancer","npm::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",25727400,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220365,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",22912387,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220365,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",22912387,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220368,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","preclinical",26554404,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220368,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","preclinical",26554404,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220371,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK T1151INST","resistance","TAE684","TAE684","alk inhibitor","preclinical",22277784,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220372,"B3","ALK",null,"NPM1-ALK","Diffuse Large B-cell Lymphoma","cltc::alk","sensitivity/response","TAE684","TAE684","alk inhibitor","preclinical",21494621,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220373,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK e6-e20, ALK Fusion I1171, EML4::ALK  V1180L","sensitivity/response","TAE684","TAE684","alk inhibitor","preclinical","18451166, 18594010, 25228534","CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220374,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK T1151INST, ALK Fusion G1202R","sensitivity/response","Tanespimycin","Tanespimycin","hsp90 inhibitor","preclinical",22277784,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220375,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","WHI-P154","WHI-P154","egfr inhibitor","preclinical",17625570,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220375,"B3","ALK",null,"NPM1-ALK","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","WHI-P154","WHI-P154","jak inhibitor","preclinical",17625570,"CIVIC","Ng_et_al_2018_Supp_2_Fusion_OCILY132-1.csv","OCI-Ly13.2-1","Cell line","lymphoma","ALCL Alk-","Fusion","10.1038/s41467-018-04356-9","Ng_et_al_2018","WES",{"$nulls":5},"NONE","NONE",0]
[220376,"B2","JAK2",null,"TRIM22-JAK2","B-lymphoblastic Leukemia/lymphoma, BCR-ABL1<U+2013>like","GOLGA5::JAK2, SSBP2::JAK2","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","case report","29773603, 25207766","CIVIC","Schrader_et_al_Fusions_RNAseq_Fusion_T-PLL_TP034.csv","TP034","Patient","lymphoma","T-PLL","Fusion","10.1038/s41467-017-02688-6","Schrader_et_al_18","RNA seq",{"$nulls":5},"NONE","NONE",0]
[220377,"B3","BCR-JAK2",null,"TRIM22-JAK2","acute_lymphocytic_leukemia","rearrangement (GoF)","sensitivity","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical",22897847,"GDKD","Schrader_et_al_Fusions_RNAseq_Fusion_T-PLL_TP034.csv","TP034","Patient","lymphoma","T-PLL","Fusion","10.1038/s41467-017-02688-6","Schrader_et_al_18","RNA seq",{"$nulls":5},"NONE","NONE",0,"x"]
[220378,"B3","JAK2",null,"TRIM22-JAK2","acute_lymphocytic_leukemia","rearrangement (GoF)","sensitivity","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical","22875628, 22899477","GDKD","Schrader_et_al_Fusions_RNAseq_Fusion_T-PLL_TP034.csv","TP034","Patient","lymphoma","T-PLL","Fusion","10.1038/s41467-017-02688-6","Schrader_et_al_18","RNA seq",{"$nulls":5},"NONE","NONE",0,"x"]
[220379,"B2","CTLA4",null,"CTLA4-CD28","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Vallois_et_al_18_targeted_Fusion_AITL_AITL1.csv","AITL1","Patient","lymphoma","AITL","Fusion","10.3324/haematol.2017.186767","Vallois_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[220380,"B2","CTLA4",null,"CTLA4-CD28","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Vallois_et_al_18_targeted_Fusion_AITL_AITL2.csv","AITL2","Patient","lymphoma","AITL","Fusion","10.3324/haematol.2017.186767","Vallois_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[220381,"B2","CTLA4",null,"CTLA4-CD28","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Vallois_et_al_18_targeted_Fusion_CTCL_CTCL1.csv","CTCL1","Patient","lymphoma","CTCL","Fusion","10.3324/haematol.2017.186767","Vallois_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[220382,"B2","CTLA4",null,"CTLA4-CD28","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Vallois_et_al_18_targeted_Fusion_CTCL_CTCL2.csv","CTCL2","Patient","lymphoma","CTCL","Fusion","10.3324/haematol.2017.186767","Vallois_et_al_18","Targeted",{"$nulls":5},"NONE","NONE",0]
[220386,"B1","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Alectinib","Alectinib","alk inhibitor","approved","26708155, 28586279, 28501140","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220391,"B1","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","approved","20979469, 23724913, 25470694","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220391,"B1","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","approved","20979469, 23724913, 25470694","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220392,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","ALK Fusion I1171","resistance","Alectinib","Alectinib","alk inhibitor","case report","25228534, 25736571","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220393,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Alectinib","Alectinib","alk inhibitor","case report",26938871,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220398,"B2","ALK",null,"ALK-GABRA2","Lung Adenocarcinoma","ALK Fusion G1202R","resistance","Crizotinib","Crizotinib","alk inhibitor","case report",22277784,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220398,"B2","ALK",null,"ALK-GABRA2","Lung Adenocarcinoma","ALK Fusion G1202R","resistance","Crizotinib","Crizotinib","met inhibitor","case report",22277784,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220399,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y, EML4::ALK L1196M, EML4::ALK T1151INST, EML4::ALK L1152R, EML4::ALK G1269A, EML4::ALK and ampl., ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","alk inhibitor","case report","20979473, 22277784, 21791641, 22235099, 23344087, 26775591","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220399,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y, EML4::ALK L1196M, EML4::ALK T1151INST, EML4::ALK L1152R, EML4::ALK G1269A, EML4::ALK and ampl., ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","case report","20979473, 22277784, 21791641, 22235099, 23344087, 26775591","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220400,"B2","ALK",null,"ALK-GABRA2","Anaplastic Large Cell Lymphoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",21345110,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220400,"B2","ALK",null,"ALK-GABRA2","Anaplastic Large Cell Lymphoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",21345110,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220401,"B2","ALK",null,"ALK-GABRA2","Cancer","EML4::ALK e20-e20","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25408655,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220401,"B2","ALK",null,"ALK-GABRA2","Cancer","EML4::ALK e20-e20","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25408655,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220402,"B2","ALK",null,"ALK-GABRA2","Diffuse Large B-cell Lymphoma","fusion, cltc::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","24330038, 26221234","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220402,"B2","ALK",null,"ALK-GABRA2","Diffuse Large B-cell Lymphoma","fusion, cltc::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","24330038, 26221234","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220403,"B2","ALK",null,"ALK-GABRA2","Epithelioid Inflammatory Myofibroblastic Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25028698,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220403,"B2","ALK",null,"ALK-GABRA2","Epithelioid Inflammatory Myofibroblastic Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25028698,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220404,"B2","ALK",null,"ALK-GABRA2","Inflammatory Myofibroblastic Tumor","RANBP2::ALK","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",20979472,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220404,"B2","ALK",null,"ALK-GABRA2","Inflammatory Myofibroblastic Tumor","RANBP2::ALK","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",20979472,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220405,"B2","ALK",null,"ALK-GABRA2","Lung Adenocarcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",25922291,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220405,"B2","ALK",null,"ALK-GABRA2","Lung Adenocarcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",25922291,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220406,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK, EML4::ALK C1156Y-L1198F, EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report","20979473, 26698910, 20979469","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220406,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK, EML4::ALK C1156Y-L1198F, EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report","20979473, 26698910, 20979469","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220407,"B2","ALK",null,"ALK-GABRA2","Thyroid Gland Anaplastic Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",24687827,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220407,"B2","ALK",null,"ALK-GABRA2","Thyroid Gland Anaplastic Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",24687827,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220408,"B2","ALK",null,"ALK-GABRA2","Vagina Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","case report",26942346,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220408,"B2","ALK",null,"ALK-GABRA2","Vagina Sarcoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","case report",26942346,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220412,"B2","ALK",null,"ALK-GABRA2","Colorectal Cancer","cad::alk","sensitivity/response","Entrectinib","Entrectinib","trk inhibitor","case report",26633560,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220413,"B2","ALK",null,"ALK-GABRA2","Lung Acinar Adenocarcinoma","EML4::ALK","resistance","Erlotinib","Erlotinib","egfr inhibitor","case report",23181703,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220414,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y-L1198F","resistance","Lorlatinib","Lorlatinib","alk inhibitor","case report",26698910,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220414,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y-L1198F","resistance","Lorlatinib","Lorlatinib","ros inhibitor","case report",26698910,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220415,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","case report",26698910,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220415,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK C1156Y","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","case report",26698910,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220416,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Retaspimycin Hydrochloride","Retaspimycin Hydrochloride","hsp90 inhibitor","case report",20940188,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220418,"B2","ALK",null,"ALK-GABRA2","inflammatory_myofibroblastic_tumor","rearrangement (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",20979472,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220418,"B2","ALK",null,"ALK-GABRA2","inflammatory_myofibroblastic_tumor","rearrangement (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",20979472,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220419,"B2","ALK",null,"ALK-GABRA2","thyroid","rearrangement (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","case report",24687827,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220419,"B2","ALK",null,"ALK-GABRA2","thyroid","rearrangement (GoF)","response","Crizotinib","Crizotinib","met inhibitor","case report",24687827,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220422,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Alectinib","Alectinib","alk inhibitor","clin. trials","23639470, 25153538","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220423,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","clin. trials",28475456,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220423,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","clin. trials",28475456,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220427,"B2","ALK",null,"ALK-GABRA2","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials",23598171,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220427,"B2","ALK",null,"ALK-GABRA2","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials",23598171,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220428,"B2","ALK",null,"ALK-GABRA2","Inflammatory Myofibroblastic Tumor","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials",23598171,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220428,"B2","ALK",null,"ALK-GABRA2","Inflammatory Myofibroblastic Tumor","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials",23598171,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220429,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","clin. trials","24478318, 27022118, 21933749, 26466010","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220429,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","clin. trials","24478318, 27022118, 21933749, 26466010","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220432,"B2","ALK",null,"ALK-GABRA2","Cancer","fusion","sensitivity/response","Entrectinib","Entrectinib","trk inhibitor","clin. trials",28183697,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220433,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","clin. trials",30413378,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220433,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","clin. trials",30413378,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220434,"B2","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","fusion","sensitivity/response","Pemetrexed","Pemetrexed","antimetabolite","clin. trials",21642865,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220435,"B2","ALK",null,"ALK-GABRA2","lung_adeno","rearrangement (GoF)","response","HSP90 Inhibitors","HSP90 Inhibitors","hsp90 inhibitor","early trials",23553849,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220436,"B2","ALK",null,"ALK-GABRA2","lymphoma","rearrangement (GoF)","response","Crizotinib","Crizotinib","alk inhibitor","early trials",24491302,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220436,"B2","ALK",null,"ALK-GABRA2","lymphoma","rearrangement (GoF)","response","Crizotinib","Crizotinib","met inhibitor","early trials",24491302,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220437,"B2","ALK",null,"ALK-GABRA2","lung_adeno","rearrangement (GoF)","response","Novel ALK Inhibitors","Novel ALK Inhibitors","alk inhibitor","early trials",23639470,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220446,"B3","ALK",null,"ALK-GABRA2","Cancer","ALK Fusion G1202R, ALK Fusion G1269A","resistance","Alectinib","Alectinib","alk inhibitor","preclinical",25727400,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220447,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK  V1180L, EML4::ALK T1151INST","resistance","Alectinib","Alectinib","alk inhibitor","preclinical","25228534, 22277784","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220448,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK L1196M","sensitivity/response","Alectinib","Alectinib","alk inhibitor","preclinical",21575866,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220449,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK e6-e20","sensitivity/response","Alvespimycin","Alvespimycin","hsp90 inhibitor","preclinical",22912387,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220450,"B3","ALK",null,"ALK-GABRA2","Cancer","ALK Fusion G1202R","resistance","Brigatinib","Brigatinib","alk inhibitor","preclinical",25727400,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220450,"B3","ALK",null,"ALK-GABRA2","Cancer","ALK Fusion G1202R","resistance","Brigatinib","Brigatinib","egfr inhibitor","preclinical",25727400,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220451,"B3","ALK",null,"ALK-GABRA2","Cancer","ALK Fusion G1269A","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","preclinical",25727400,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220451,"B3","ALK",null,"ALK-GABRA2","Cancer","ALK Fusion G1269A","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","preclinical",25727400,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220452,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK  V1180L","sensitivity/response","Brigatinib","Brigatinib","alk inhibitor","preclinical",25228534,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220452,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK  V1180L","sensitivity/response","Brigatinib","Brigatinib","egfr inhibitor","preclinical",25228534,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220456,"B3","ALK",null,"ALK-GABRA2","Cancer","ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical",22034911,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220456,"B3","ALK",null,"ALK-GABRA2","Cancer","ALK Fusion F1245C","resistance","Crizotinib","Crizotinib","met inhibitor","preclinical",22034911,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220457,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","F1174L, EML4::ALK and ampl., ALK Fusion G1202R, EML4::ALK L1196M, EML4::ALK S1206Y, ALK Fusion I1171, EML4::ALK  V1180L, EML4::ALK C1156Y","resistance","Crizotinib","Crizotinib","alk inhibitor","preclinical","21030459, 22277784, 25228534, 24675041","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220457,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","F1174L, EML4::ALK and ampl., ALK Fusion G1202R, EML4::ALK L1196M, EML4::ALK S1206Y, ALK Fusion I1171, EML4::ALK  V1180L, EML4::ALK C1156Y","resistance","Crizotinib","Crizotinib","met inhibitor","preclinical","21030459, 22277784, 25228534, 24675041","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220458,"B3","ALK",null,"ALK-GABRA2","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",18089725,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220458,"B3","ALK",null,"ALK-GABRA2","Anaplastic Large Cell Lymphoma","npm::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",18089725,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220459,"B3","ALK",null,"ALK-GABRA2","Cancer","npm::alk","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",25727400,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220459,"B3","ALK",null,"ALK-GABRA2","Cancer","npm::alk","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",25727400,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220460,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","alk inhibitor","preclinical",22912387,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220460,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK e20-e20, EML4::ALK e6-e20","sensitivity/response","Crizotinib","Crizotinib","met inhibitor","preclinical",22912387,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220463,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","Lorlatinib","Lorlatinib","alk inhibitor","preclinical",26554404,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220463,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","Lorlatinib","Lorlatinib","ros inhibitor","preclinical",26554404,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220466,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK T1151INST","resistance","TAE684","TAE684","alk inhibitor","preclinical",22277784,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220467,"B3","ALK",null,"ALK-GABRA2","Diffuse Large B-cell Lymphoma","cltc::alk","sensitivity/response","TAE684","TAE684","alk inhibitor","preclinical",21494621,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220468,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK e6-e20, ALK Fusion I1171, EML4::ALK  V1180L","sensitivity/response","TAE684","TAE684","alk inhibitor","preclinical","18451166, 18594010, 25228534","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220469,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK T1151INST, ALK Fusion G1202R","sensitivity/response","Tanespimycin","Tanespimycin","hsp90 inhibitor","preclinical",22277784,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220470,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","WHI-P154","WHI-P154","egfr inhibitor","preclinical",17625570,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220470,"B3","ALK",null,"ALK-GABRA2","Lung Non-small Cell Carcinoma","EML4::ALK","sensitivity/response","WHI-P154","WHI-P154","jak inhibitor","preclinical",17625570,"CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk+_GPS-27-28.csv","GPS-27-28","Patient","lymphoma","ALCL Alk+","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220471,"B2","JAK2",null,"STAM-JAK2","B-lymphoblastic Leukemia/lymphoma, BCR-ABL1<U+2013>like","GOLGA5::JAK2, SSBP2::JAK2","sensitivity/response","Ruxolitinib","Ruxolitinib","jak inhibitor","case report","29773603, 25207766","CIVIC","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk-_GPS-38-39.csv","GPS-38-39","Patient","lymphoma","ALCL Alk-","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0]
[220472,"B3","BCR-JAK2",null,"STAM-JAK2","acute_lymphocytic_leukemia","rearrangement (GoF)","sensitivity","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical",22897847,"GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk-_GPS-38-39.csv","GPS-38-39","Patient","lymphoma","ALCL Alk-","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220473,"B3","JAK2",null,"STAM-JAK2","acute_lymphocytic_leukemia","rearrangement (GoF)","sensitivity","Ruxolitinib","Ruxolitinib","jak inhibitor","preclinical","22875628, 22899477","GDKD","Watatani_et_al_19_SVs_Fusions_WES_Fusion_ALCL_Alk-_GPS-38-39.csv","GPS-38-39","Patient","lymphoma","ALCL Alk-","Fusion","10.1038/s41375-019-0473-1","Watatani_et_al_19","WES",{"$nulls":5},"NONE","NONE",0,"x"]
[220474,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_10.csv",10,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220475,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_12.csv",12,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220476,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_14.csv",14,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220477,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_16.csv",16,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220478,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_17.csv",17,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220479,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_18.csv",18,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220480,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_19.csv",19,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220481,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_20.csv",20,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220482,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_26.csv",26,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220483,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_29.csv",29,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220484,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_31.csv",31,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220485,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_32.csv",32,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220486,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_33.csv",33,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220487,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_38.csv",38,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220488,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_3.csv",3,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220489,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_40.csv",40,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220490,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_41.csv",41,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220491,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_42.csv",42,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220492,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_4.csv",4,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220493,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_5.csv",5,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220494,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_6.csv",6,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220495,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_7.csv",7,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
[220496,"B2","CTLA4",null,"CD28-CTLA4","Sezary's Disease","CTLA4::CD28","sensitivity/response","Ipilimumab","Ipilimumab","ctla4 antibody","case report",25802883,"CIVIC","Yoo_et_al_16_targeted_Fusion_AITL_8.csv",8,"Patient","lymphoma","AITL","Fusion","10.3324/haematol.2015.139253","Yoo_et_al_16","Targeted",{"$nulls":5},"NONE","NONE",0]
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