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["Supplementary Table S1. STROBE-MR Checklist. (Skrivankova et al., 2021)"]
["Item No.","Section","Checklist item"]
["Title and abstract"]
[1,"Title and abstract","Indicate mendelian randomization (MR) as the study’s design in the title and/or the abstract if that is a main purpose of the study."]
["Introduction"]
[2,"Background","Explain the scientific background and rationale for the reported study. What is the exposure? Is a potential causal relationship between exposure and outcome plausible? Justify why MR is a helpful method to address the study question."]
[3,"Objectives","State specific objectives clearly, including prespecified causal hypotheses (if any). State that MR is a method that, under specific assumptions, intends to estimate causal effects."]
["Methods"]
[4,"Study design and data sources","Present key elements of the study design early in the article. Consider including a table listing sources of data for all phases of the study. For each data source contributing to the analysis, describe the following:"]
[null,"a","Setting: Describe the study design and the underlying population, if possible. Describe the setting, locations, and relevant dates, including periods of recruitment, exposure, follow-up, and data collection, when available."]
[null,"b","Participants: Report the eligibility criteria and the sources and methods of selection of participants. Report the sample size and whether any power or sample size calculations were carried out prior to the main analysis."]
[null,"c","Describe measurement, quality control, and selection of genetic variants."]
[null,"d","For each exposure, outcome, and other relevant variables, describe methods of assessment and diagnostic criteria for diseases."]
[null,"e","Provide details of ethics committee approval and participant informed consent, if relevant."]
[5,"Assumptions","Explicitly state the 3 core instrumental variable (IV) assumptions for the main analysis (relevance, independence, and exclusion restriction), as well assumptions for any additional or sensitivity analysis."]
[6,"Statistical methods: main analysis","Describe statistical methods and statistics used."]
[null,"a","Describe how quantitative variables were handled in the analyses (ie, scale, units, model)."]
[null,"b","Describe how genetic variants were handled in the analyses and, if applicable, how their weights were selected."]
[null,"c","Describe the MR estimator (eg, 2-stage least squares, Wald ratio) and related statistics. Detail the included covariates and, in case of 2-sample MR, whether the same covariate set was used for adjustment in the 2 samples."]
[null,"d","Explain how missing data were addressed."]
[null,"e","If applicable, indicate how multiple testing was addressed."]
[7,"Assessment of assumptions","Describe any methods or prior knowledge used to assess the assumptions or justify their validity."]
[8,"Sensitivity analyses\nand additional analyses","Describe any sensitivity analyses or additional analyses performed (eg, comparison of effect estimates from different approaches, independent replication, bias analytic techniques, validation of instruments, simulations)."]
[9,"Software and\npreregistration"]
[null,"a","Name statistical software and package(s), including version and settings used."]
[null,"b","State whether the study protocol and details were preregistered (as well as when and where)."]
["Results"]
[10,"Descriptive data"]
[null,"a","Report the numbers of individuals at each stage of included studies and reasons for exclusion. Consider use of a flow diagram."]
[null,"b","Report summary statistics for phenotypic exposure(s), outcome(s), and other relevant variables (eg, means, SDs, proportions)."]
[null,"c","If the data sources include meta-analyses of previous studies, provide the assessments of heterogeneity across these studies."]
[null,"d","For 2-sample MR:\ni. Provide justification of the similarity of the genetic variant–exposure associations between the exposure and outcome samples.\nii. Provide information on the number of individuals who overlap between the exposure and outcome studies."]
[11,"Main results"]
[null,"a","Report the associations between genetic variant and exposure and between genetic variant and outcome, preferably on an interpretable scale."]
[null,"b","Report MR estimates of the relationship between exposure and outcome and the measures of uncertainty from the MR analysis, on an interpretable scale, such as odds ratio or relative risk per SD difference."]
[null,"c","If relevant, consider translating estimates of relative risk into absolute risk for a meaningful time period."]
[null,"d","Consider plots to visualize results (eg, forest plot, scatterplot of associations between genetic variants and outcome vs between genetic variants and exposure)."]
[12,"Assessment\nof assumptions"]
[null,"a","Report the assessment of the validity of the assumptions."]
[null,"b","Report any additional statistics (eg, assessments of heterogeneity across genetic variants, such as I2, Q statistic, or E-value)."]
[13,"Sensitivity analyses\nand additional analyses"]
[null,"a","Report any sensitivity analyses to assess the robustness of the main results to violations of the assumptions."]
[null,"b","Report results from other sensitivity analyses or additional analyses."]
[null,"c","Report any assessment of the direction of the causal relationship (eg, bidirectional MR)."]
[null,"d","When relevant, report and compare with estimates from non-MR analyses."]
[null,"e","Consider additional plots to visualize results (eg, leave-one-out analyses)."]
["Discussion"]
[14,"Key results","Summarize key results with reference to study objectives."]
[15,"Limitations","Discuss limitations of the study, taking into account the validity of the IV assumptions, other sources of potential bias, and imprecision. Discuss both direction and magnitude of any potential bias and any efforts to address them."]
[16,"Interpretation"]
[null,"a","Meaning: Give a cautious overall interpretation of results in the context of their limitations and in comparison with other studies."]
[null,"b","Mechanism: Discuss underlying biological mechanisms that could drive a potential causal relationship between the investigated exposure and the outcome, and whether the gene-environment equivalence assumption is reasonable. Use causal language carefully, clarifying that IV estimates may provide causal effects only under certain assumptions."]
[null,"c","Clinical relevance: Discuss whether the results have clinical or public policy relevance, and to what extent they inform effect sizes of possible interventions."]
[17,"Generalizability","Discuss the generalizability of the study results (a) to other populations, (b) across other exposure periods/timings, and (c) across other levels of exposure."]
["Other Information"]
[18,"Funding","Describe sources of funding and the role of funders in the present study and, if applicable, sources of funding for the databases and original study or studies on which the present study is based."]
[19,"Data and data sharing","Provide the data used to perform all analyses or report where and how the data can be accessed, and reference these sources in the article. Provide the statistical code needed to reproduce the results in the article or report whether the code is publicly accessible and, if so, where."]
[20,"Conflicts of interest","All authors should declare all potential conflicts of interest."]
["Reference:\nSkrivankova, V.W., Richmond, R.C., Woolf, B.A.R., Yarmolinsky, J., Davies, N.M., Swanson, S.A., et al. (2021). Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement. JAMA 326, 1614-1621. doi: 10.1001/jama.2021.18236 "]

{"sheet":"Table S2","index":1,"n_rows":210,"n_cols":6,"rows_kept":210,"merged":[[0,0,0,5],[1,0,1,1],[1,4,1,5]],"flags":["formulas_cached_only"]}
["Table S2.GWAS names corresponding to intestinal flora and circulating inflammatory proteins."]
["Gut microbiota",{"$nulls":3},"Circulating Inflammatory proteins"]
["GWASid","name",null,null,"GWASid","reportedTrait"]
["GCST90027651","k_Bacteria.p_Actinobacteria.c_Actinobacteria",null,null,"GCST90274759","Adenosine Deaminase levels"]
["GCST90027652","k_Bacteria.p_Bacteroidetes.c_Bacteroidia",null,null,"GCST90274760","Artemin levels"]
["GCST90027653","k_Bacteria.p_Firmicutes.c_Bacilli",null,null,"GCST90274761","Axin-1 levels"]
["GCST90027654","k_Bacteria.p_Firmicutes.c_Clostridia",null,null,"GCST90274762","beta-nerve growth factor levels"]
["GCST90027655","k_Bacteria.p_Firmicutes.c_Erysipelotrichia",null,null,"GCST90274763","Caspase 8 levels"]
["GCST90027656","k_Bacteria.p_Firmicutes.c_Negativicutes",null,null,"GCST90274765","C-C motif chemokine 19 levels"]
["GCST90027657","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria",null,null,"GCST90274766","C-C motif chemokine 20 levels"]
["GCST90027658","k_Bacteria.p_Proteobacteria.c_Deltaproteobacteria",null,null,"GCST90274767","C-C motif chemokine 23 levels"]
["GCST90027659","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria",null,null,"GCST90274768","C-C motif chemokine 25 levels"]
["GCST90027660","k_Bacteria.p_Verrucomicrobia.c_Verrucomicrobiae",null,null,"GCST90274769","C-C motif chemokine 28 levels"]
["GCST90027661","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Actinomycetales.f_Micrococcaceae",null,null,"GCST90274770","C-C motif chemokine 4 levels"]
["GCST90027662","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Bifidobacteriales.f_Bifidobacteriaceae",null,null,"GCST90274772","CD40L receptor levels"]
["GCST90027663","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae",null,null,"GCST90274775","CUB domain-containing protein 1 levels"]
["GCST90027664","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae",null,null,"GCST90274779","C-X-C motif chemokine 1 levels"]
["GCST90027665","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidales_noname",null,null,"GCST90274780","C-X-C motif chemokine 10 levels"]
["GCST90027666","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae",null,null,"GCST90274781","C-X-C motif chemokine 11 levels"]
["GCST90027667","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Prevotellaceae",null,null,"GCST90274782","C-X-C motif chemokine 5 levels"]
["GCST90027668","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae",null,null,"GCST90274783","C-X-C motif chemokine 6 levels"]
["GCST90027669","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales.f_Lactobacillaceae",null,null,"GCST90274784","C-X-C motif chemokine 9 levels"]
["GCST90027670","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales.f_Streptococcaceae",null,null,"GCST90274777","Cystatin D levels"]
["GCST90027671","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiaceae",null,null,"GCST90274785","Delta and Notch-like epidermal growth factor-related receptor levels"]
["GCST90027672","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiales_noname",null,null,"GCST90274764","Eotaxin levels"]
["GCST90027673","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Eubacteriaceae",null,null,"GCST90274758","Eukaryotic translation initiation factor 4E-binding protein 1 levels"]
["GCST90027674","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae",null,null,"GCST90274787","Fibroblast growth factor 19 levels"]
["GCST90027675","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Oscillospiraceae",null,null,"GCST90274788","Fibroblast growth factor 21 levels"]
["GCST90027676","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae",null,null,"GCST90274789","Fibroblast growth factor 23 levels"]
["GCST90027677","k_Bacteria.p_Firmicutes.c_Erysipelotrichia.o_Erysipelotrichales.f_Erysipelotrichaceae",null,null,"GCST90274790","Fibroblast growth factor 5 levels"]
["GCST90027678","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales.f_Acidaminococcaceae",null,null,"GCST90274791","Fms-related tyrosine kinase 3 ligand levels"]
["GCST90027679","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales.f_Veillonellaceae",null,null,"GCST90274778","Fractalkine levels"]
["GCST90027680","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Burkholderiales_noname",null,null,"GCST90274792","Glial cell line-derived neurotrophic factor levels"]
["GCST90027681","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Oxalobacteraceae",null,null,"GCST90274793","Hepatocyte growth factor levels"]
["GCST90027682","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Sutterellaceae",null,null,"GCST90274794","Interferon gamma levels"]
["GCST90027683","k_Bacteria.p_Proteobacteria.c_Deltaproteobacteria.o_Desulfovibrionales.f_Desulfovibrionaceae",null,null,"GCST90274795","Interleukin-10 levels"]
["GCST90027684","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Enterobacteriales.f_Enterobacteriaceae",null,null,"GCST90274796","Interleukin-10 receptor subunit alpha levels"]
["GCST90027685","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Pasteurellales.f_Pasteurellaceae",null,null,"GCST90274797","Interleukin-10 receptor subunit beta levels"]
["GCST90027686","k_Bacteria.p_Verrucomicrobia.c_Verrucomicrobiae.o_Verrucomicrobiales.f_Verrucomicrobiaceae",null,null,"GCST90274798","Interleukin-12 subunit beta levels"]
["GCST90027687","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Actinomycetales.f_Micrococcaceae.g_Rothia",null,null,"GCST90274799","Interleukin-13 levels"]
["GCST90027688","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Bifidobacteriales.f_Bifidobacteriaceae.g_Bifidobacterium",null,null,"GCST90274800","Interleukin-15 receptor subunit alpha levels"]
["GCST90027689","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae.g_Adlercreutzia",null,null,"GCST90274801","Interleukin-17A levels"]
["GCST90027690","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae.g_Collinsella",null,null,"GCST90274802","Interleukin-17C levels"]
["GCST90027691","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae.g_Eggerthella",null,null,"GCST90274803","Interleukin-18 levels"]
["GCST90027692","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae.g_Gordonibacter",null,null,"GCST90274804","interleukin-18 receptor 1 levels"]
["GCST90027693","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides",null,null,"GCST90274805","Interleukin-1-alpha levels"]
["GCST90027694","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidales_noname.g_Bacteroidales_noname",null,null,"GCST90274806","Interleukin-2 levels"]
["GCST90027695","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Barnesiella",null,null,"GCST90274811","Interleukin-2 receptor subunit beta levels"]
["GCST90027696","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Coprobacter",null,null,"GCST90274807","Interleukin-20 levels"]
["GCST90027697","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Odoribacter",null,null,"GCST90274808","Interleukin-20 receptor subunit alpha levels"]
["GCST90027698","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Parabacteroides",null,null,"GCST90274809","Interleukin-22 receptor subunit alpha-1 levels"]
["GCST90027699","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Prevotellaceae.g_Paraprevotella",null,null,"GCST90274810","Interleukin-24 levels"]
["GCST90027700","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Prevotellaceae.g_Prevotella",null,null,"GCST90274812","Interleukin-33 levels"]
["GCST90027701","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae.g_Alistipes",null,null,"GCST90274813","Interleukin-4 levels"]
["GCST90027702","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales.f_Lactobacillaceae.g_Lactobacillus",null,null,"GCST90274814","Interleukin-5 levels"]
["GCST90027703","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales.f_Streptococcaceae.g_Streptococcus",null,null,"GCST90274815","Interleukin-6 levels"]
["GCST90027704","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiaceae.g_Clostridium",null,null,"GCST90274816","Interleukin-7 levels"]
["GCST90027705","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiales_noname.g_Flavonifractor",null,null,"GCST90274817","Interleukin-8 levels"]
["GCST90027706","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiales_noname.g_Pseudoflavonifractor",null,null,"GCST90274818","Latency-associated peptide transforming growth factor beta 1 levels"]
["GCST90027707","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Eubacteriaceae.g_Eubacterium",null,null,"GCST90274819","Leukemia inhibitory factor levels"]
["GCST90027708","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Blautia",null,null,"GCST90274820","Leukemia inhibitory factor receptor levels"]
["GCST90027709","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Butyrivibrio",null,null,"GCST90274776","Macrophage colony-stimulating factor 1 levels"]
["GCST90027710","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Coprococcus",null,null,"GCST90274825","Macrophage inflammatory protein 1a levels"]
["GCST90027711","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Dorea",null,null,"GCST90274826","Matrix metalloproteinase-1 levels"]
["GCST90027712","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Lachnospiraceae_noname",null,null,"GCST90274827","Matrix metalloproteinase-10 levels"]
["GCST90027713","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Roseburia",null,null,"GCST90274822","Monocyte chemoattractant protein 2 levels"]
["GCST90027714","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Oscillospiraceae.g_Oscillibacter",null,null,"GCST90274821","Monocyte chemoattractant protein-1 levels"]
["GCST90027715","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Anaerotruncus",null,null,"GCST90274823","Monocyte chemoattractant protein-3 levels"]
["GCST90027716","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Faecalibacterium",null,null,"GCST90274824","Monocyte chemoattractant protein-4 levels"]
["GCST90027717","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Ruminococcaceae_noname",null,null,"GCST90274771","Natural killer cell receptor 2B4 levels"]
["GCST90027718","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Ruminococcus",null,null,"GCST90274829","Neurotrophin-3 levels"]
["GCST90027719","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Subdoligranulum",null,null,"GCST90274828","Neurturin levels"]
["GCST90027720","k_Bacteria.p_Firmicutes.c_Erysipelotrichia.o_Erysipelotrichales.f_Erysipelotrichaceae.g_Erysipelotrichaceae_noname",null,null,"GCST90274831","Oncostatin-M levels"]
["GCST90027721","k_Bacteria.p_Firmicutes.c_Erysipelotrichia.o_Erysipelotrichales.f_Erysipelotrichaceae.g_Holdemania",null,null,"GCST90274830","Osteoprotegerin levels"]
["GCST90027722","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales.f_Acidaminococcaceae.g_Phascolarctobacterium",null,null,"GCST90274832","Programmed cell death 1 ligand 1 levels"]
["GCST90027723","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales.f_Veillonellaceae.g_Dialister",null,null,"GCST90274786","Protein S100-A12 levels"]
["GCST90027724","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales.f_Veillonellaceae.g_Veillonella",null,null,"GCST90274835","Signaling lymphocytic activation molecule levels"]
["GCST90027725","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Burkholderiales_noname.g_Burkholderiales_noname",null,null,"GCST90274834","SIR2-like protein 2 levels"]
["GCST90027726","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Oxalobacteraceae.g_Oxalobacter",null,null,"GCST90274837","STAM binding protein levels"]
["GCST90027727","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Sutterellaceae.g_Parasutterella",null,null,"GCST90274833","Stem cell factor levels"]
["GCST90027728","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Sutterellaceae.g_Sutterellaceae_unclassified",null,null,"GCST90274836","Sulfotransferase 1A1 levels"]
["GCST90027729","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Sutterellaceae.g_Sutterella",null,null,"GCST90274773","T-cell surface glycoprotein CD5 levels"]
["GCST90027730","k_Bacteria.p_Proteobacteria.c_Deltaproteobacteria.o_Desulfovibrionales.f_Desulfovibrionaceae.g_Bilophila",null,null,"GCST90274774","T-cell surface glycoprotein CD6 isoform levels"]
["GCST90027731","k_Bacteria.p_Proteobacteria.c_Deltaproteobacteria.o_Desulfovibrionales.f_Desulfovibrionaceae.g_Desulfovibrio",null,null,"GCST90274845","Thymic stromal lymphopoietin levels"]
["GCST90027732","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Enterobacteriales.f_Enterobacteriaceae.g_Escherichia",null,null,"GCST90274840","TNF-beta levels"]
["GCST90027733","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Pasteurellales.f_Pasteurellaceae.g_Haemophilus",null,null,"GCST90274844","TNF-related activation-induced cytokine levels"]
["GCST90027734","k_Bacteria.p_Verrucomicrobia.c_Verrucomicrobiae.o_Verrucomicrobiales.f_Verrucomicrobiaceae.g_Akkermansia",null,null,"GCST90274843","TNF-related apoptosis-inducing ligand levels"]
["GCST90027735","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Actinomycetales",null,null,"GCST90274838","Transforming growth factor-alpha levels"]
["GCST90027736","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Bifidobacteriales",null,null,"GCST90274839","Tumor necrosis factor levels"]
["GCST90027737","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales",null,null,"GCST90274846","Tumor necrosis factor ligand superfamily member 12 levels"]
["GCST90027738","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales",null,null,"GCST90274842","Tumor necrosis factor ligand superfamily member 14 levels"]
["GCST90027739","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales",null,null,"GCST90274841","Tumor necrosis factor receptor superfamily member 9 levels"]
["GCST90027740","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales",null,null,"GCST90274847","Urokinase-type plasminogen activator levels"]
["GCST90027741","k_Bacteria.p_Firmicutes.c_Erysipelotrichia.o_Erysipelotrichales",null,null,"GCST90274848","Vascular endothelial growth factor A levels"]
["GCST90027742","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales"]
["GCST90027743","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales"]
["GCST90027744","k_Bacteria.p_Proteobacteria.c_Deltaproteobacteria.o_Desulfovibrionales"]
["GCST90027745","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Enterobacteriales"]
["GCST90027746","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Pasteurellales"]
["GCST90027747","k_Bacteria.p_Verrucomicrobia.c_Verrucomicrobiae.o_Verrucomicrobiales"]
["GCST90027748","k_Bacteria.p_Actinobacteria"]
["GCST90027749","k_Bacteria.p_Bacteroidetes"]
["GCST90027750","k_Bacteria.p_Firmicutes"]
["GCST90027751","k_Bacteria.p_Proteobacteria"]
["GCST90027752","k_Bacteria.p_Verrucomicrobia"]
["GCST90027753","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Actinomycetales.f_Micrococcaceae.g_Rothia.s_Rothia_mucilaginosa"]
["GCST90027754","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Bifidobacteriales.f_Bifidobacteriaceae.g_Bifidobacterium.s_Bifidobacterium_adolescentis"]
["GCST90027755","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Bifidobacteriales.f_Bifidobacteriaceae.g_Bifidobacterium.s_Bifidobacterium_bifidum"]
["GCST90027756","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Bifidobacteriales.f_Bifidobacteriaceae.g_Bifidobacterium.s_Bifidobacterium_catenulatum"]
["GCST90027757","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Bifidobacteriales.f_Bifidobacteriaceae.g_Bifidobacterium.s_Bifidobacterium_longum"]
["GCST90027758","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae.g_Adlercreutzia.s_Adlercreutzia_equolifaciens"]
["GCST90027759","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae.g_Collinsella.s_Collinsella_aerofaciens"]
["GCST90027760","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae.g_Eggerthella.s_Eggerthella_unclassified"]
["GCST90027761","k_Bacteria.p_Actinobacteria.c_Actinobacteria.o_Coriobacteriales.f_Coriobacteriaceae.g_Gordonibacter.s_Gordonibacter_pamelaeae"]
["GCST90027762","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidales_noname.g_Bacteroidales_noname.s_Bacteroidales_bacterium_ph8"]
["GCST90027763","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Barnesiella.s_Barnesiella_intestinihominis"]
["GCST90027764","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Coprobacter.s_Coprobacter_fastidiosus"]
["GCST90027765","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Odoribacter.s_Odoribacter_splanchnicus"]
["GCST90027766","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Parabacteroides.s_Parabacteroides_distasonis"]
["GCST90027767","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Parabacteroides.s_Parabacteroides_goldsteinii"]
["GCST90027768","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Parabacteroides.s_Parabacteroides_johnsonii"]
["GCST90027769","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Parabacteroides.s_Parabacteroides_merdae"]
["GCST90027770","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Porphyromonadaceae.g_Parabacteroides.s_Parabacteroides_unclassified"]
["GCST90027771","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Prevotellaceae.g_Paraprevotella.s_Paraprevotella_clara"]
["GCST90027772","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Prevotellaceae.g_Paraprevotella.s_Paraprevotella_unclassified"]
["GCST90027773","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Prevotellaceae.g_Paraprevotella.s_Paraprevotella_xylaniphila"]
["GCST90027774","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Prevotellaceae.g_Prevotella.s_Prevotella_copri"]
["GCST90027775","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae.g_Alistipes.s_Alistipes_finegoldii"]
["GCST90027776","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae.g_Alistipes.s_Alistipes_indistinctus"]
["GCST90027777","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae.g_Alistipes.s_Alistipes_onderdonkii"]
["GCST90027778","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae.g_Alistipes.s_Alistipes_putredinis"]
["GCST90027779","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae.g_Alistipes.s_Alistipes_senegalensis"]
["GCST90027780","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae.g_Alistipes.s_Alistipes_shahii"]
["GCST90027781","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Rikenellaceae.g_Alistipes.s_Alistipes_sp_AP11"]
["GCST90027782","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales.f_Lactobacillaceae.g_Lactobacillus.s_Lactobacillus_delbrueckii"]
["GCST90027783","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales.f_Streptococcaceae.g_Streptococcus.s_Streptococcus_parasanguinis"]
["GCST90027784","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales.f_Streptococcaceae.g_Streptococcus.s_Streptococcus_salivarius"]
["GCST90027785","k_Bacteria.p_Firmicutes.c_Bacilli.o_Lactobacillales.f_Streptococcaceae.g_Streptococcus.s_Streptococcus_thermophilus"]
["GCST90027786","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiaceae.g_Clostridium.s_Clostridium_asparagiforme"]
["GCST90027787","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiaceae.g_Clostridium.s_Clostridium_leptum"]
["GCST90027788","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiales_noname.g_Flavonifractor.s_Flavonifractor_plautii"]
["GCST90027789","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Clostridiales_noname.g_Pseudoflavonifractor.s_Pseudoflavonifractor_capillosus"]
["GCST90027790","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Eubacteriaceae.g_Eubacterium.s_Eubacterium_eligens"]
["GCST90027791","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Eubacteriaceae.g_Eubacterium.s_Eubacterium_hallii"]
["GCST90027792","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Eubacteriaceae.g_Eubacterium.s_Eubacterium_ramulus"]
["GCST90027793","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Eubacteriaceae.g_Eubacterium.s_Eubacterium_rectale"]
["GCST90027794","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Eubacteriaceae.g_Eubacterium.s_Eubacterium_siraeum"]
["GCST90027795","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Eubacteriaceae.g_Eubacterium.s_Eubacterium_ventriosum"]
["GCST90027796","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Oscillospiraceae.g_Oscillibacter.s_Oscillibacter_unclassified"]
["GCST90027797","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Faecalibacterium.s_Faecalibacterium_prausnitzii"]
["GCST90027798","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Ruminococcaceae_noname.s_Ruminococcaceae_bacterium_D16"]
["GCST90027799","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Ruminococcus.s_Ruminococcus_bromii"]
["GCST90027800","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Ruminococcus.s_Ruminococcus_callidus"]
["GCST90027801","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Ruminococcus.s_Ruminococcus_lactaris"]
["GCST90027802","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Ruminococcaceae.g_Subdoligranulum.s_Subdoligranulum_unclassified"]
["GCST90027803","k_Bacteria.p_Firmicutes.c_Erysipelotrichia.o_Erysipelotrichales.f_Erysipelotrichaceae.g_Erysipelotrichaceae_noname.s_Eubacterium_biforme"]
["GCST90027804","k_Bacteria.p_Firmicutes.c_Erysipelotrichia.o_Erysipelotrichales.f_Erysipelotrichaceae.g_Holdemania.s_Holdemania_filiformis"]
["GCST90027805","k_Bacteria.p_Firmicutes.c_Erysipelotrichia.o_Erysipelotrichales.f_Erysipelotrichaceae.g_Holdemania.s_Holdemania_unclassified"]
["GCST90027806","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales.f_Acidaminococcaceae.g_Phascolarctobacterium.s_Phascolarctobacterium_succinatutens"]
["GCST90027807","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales.f_Veillonellaceae.g_Dialister.s_Dialister_invisus"]
["GCST90027808","k_Bacteria.p_Firmicutes.c_Negativicutes.o_Selenomonadales.f_Veillonellaceae.g_Veillonella.s_Veillonella_unclassified"]
["GCST90027809","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Burkholderiales_noname.g_Burkholderiales_noname.s_Burkholderiales_bacterium_1_1_47"]
["GCST90027810","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Oxalobacteraceae.g_Oxalobacter.s_Oxalobacter_formigenes"]
["GCST90027811","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Sutterellaceae.g_Parasutterella.s_Parasutterella_excrementihominis"]
["GCST90027812","k_Bacteria.p_Proteobacteria.c_Betaproteobacteria.o_Burkholderiales.f_Sutterellaceae.g_Sutterella.s_Sutterella_wadsworthensis"]
["GCST90027813","k_Bacteria.p_Proteobacteria.c_Deltaproteobacteria.o_Desulfovibrionales.f_Desulfovibrionaceae.g_Bilophila.s_Bilophila_unclassified"]
["GCST90027814","k_Bacteria.p_Proteobacteria.c_Deltaproteobacteria.o_Desulfovibrionales.f_Desulfovibrionaceae.g_Bilophila.s_Bilophila_wadsworthia"]
["GCST90027815","k_Bacteria.p_Proteobacteria.c_Deltaproteobacteria.o_Desulfovibrionales.f_Desulfovibrionaceae.g_Desulfovibrio.s_Desulfovibrio_piger"]
["GCST90027816","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Enterobacteriales.f_Enterobacteriaceae.g_Escherichia.s_Escherichia_coli"]
["GCST90027817","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Enterobacteriales.f_Enterobacteriaceae.g_Escherichia.s_Escherichia_unclassified"]
["GCST90027818","k_Bacteria.p_Proteobacteria.c_Gammaproteobacteria.o_Pasteurellales.f_Pasteurellaceae.g_Haemophilus.s_Haemophilus_parainfluenzae"]
["GCST90027819","k_Bacteria.p_Verrucomicrobia.c_Verrucomicrobiae.o_Verrucomicrobiales.f_Verrucomicrobiaceae.g_Akkermansia.s_Akkermansia_muciniphila"]
["GCST90027820","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_caccae"]
["GCST90027821","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_cellulosilyticus"]
["GCST90027822","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_clarus"]
["GCST90027823","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_coprocola"]
["GCST90027824","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_dorei"]
["GCST90027825","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_eggerthii"]
["GCST90027826","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_faecis"]
["GCST90027827","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_finegoldii"]
["GCST90027828","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_fragilis"]
["GCST90027829","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_intestinalis"]
["GCST90027830","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_massiliensis"]
["GCST90027831","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_nordii"]
["GCST90027832","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_ovatus"]
["GCST90027833","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_plebeius"]
["GCST90027834","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_salyersiae"]
["GCST90027835","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_stercoris"]
["GCST90027836","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_thetaiotaomicron"]
["GCST90027837","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_uniformis"]
["GCST90027838","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_vulgatus"]
["GCST90027839","k_Bacteria.p_Bacteroidetes.c_Bacteroidia.o_Bacteroidales.f_Bacteroidaceae.g_Bacteroides.s_Bacteroides_xylanisolvens"]
["GCST90027840","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Blautia.s_Ruminococcus_obeum"]
["GCST90027841","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Blautia.s_Ruminococcus_torques"]
["GCST90027842","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Butyrivibrio.s_Butyrivibrio_crossotus"]
["GCST90027843","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Coprococcus.s_Coprococcus_catus"]
["GCST90027844","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Coprococcus.s_Coprococcus_comes"]
["GCST90027845","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Coprococcus.s_Coprococcus_sp_ART55_1"]
["GCST90027846","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Dorea.s_Dorea_formicigenerans"]
["GCST90027847","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Dorea.s_Dorea_longicatena"]
["GCST90027848","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Dorea.s_Dorea_unclassified"]
["GCST90027849","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Lachnospiraceae_noname.s_Lachnospiraceae_bacterium_1_1_57FAA"]
["GCST90027850","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Lachnospiraceae_noname.s_Lachnospiraceae_bacterium_3_1_46FAA"]
["GCST90027851","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Lachnospiraceae_noname.s_Lachnospiraceae_bacterium_5_1_63FAA"]
["GCST90027852","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Lachnospiraceae_noname.s_Lachnospiraceae_bacterium_7_1_58FAA"]
["GCST90027853","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Lachnospiraceae_noname.s_Lachnospiraceae_bacterium_8_1_57FAA"]
["GCST90027854","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Roseburia.s_Roseburia_hominis"]
["GCST90027855","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Roseburia.s_Roseburia_intestinalis"]
["GCST90027856","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Roseburia.s_Roseburia_inulinivorans"]
["GCST90027857","k_Bacteria.p_Firmicutes.c_Clostridia.o_Clostridiales.f_Lachnospiraceae.g_Roseburia.s_Roseburia_unclassified"]

{"sheet":"Table S3","index":2,"n_rows":74,"n_cols":10,"rows_kept":74,"merged":[[0,0,0,5],[0,6,0,9],[1,0,2,0],[1,1,2,1],[1,2,2,2],[1,3,2,3],[1,4,1,6],[1,7,1,9]],"flags":["formulas_cached_only"]}
["Table S3.Instrumental variables used in MR analysis of the association between gut microbiota and IgA nephropathy."]
["Bacterial taxa(exposure)","SNP","Effect allele","Other allele","exposure(Bacterial)",null,null,"outcome(IgA nephropathy)"]
[{"$nulls":4},"beta.exposure","se.exposure","pval.exposure","beta.outcome","se.outcome","pval.outcome"]
["g_Roseburia","rs11748902","G","C",{"v":0.166532692452214,"d":"0.1665"},{"v":0.0370842946785559,"d":"0.0371"},{"v":7.10052086602456e-06,"d":"7.10E-06"},{"v":-0.0551616,"d":"-0.0552"},{"v":0.0954298,"d":"0.0954"},{"v":0.563242,"d":"0.5632"}]
["g_Roseburia","rs11789010","C","T",{"v":-0.0991024090578546,"d":"-0.0991"},{"v":0.0190993346376123,"d":"0.0191"},{"v":2.11666567864134e-07,"d":"2.12E-07"},{"v":0.142097,"d":"0.1421"},{"v":0.0661089,"d":"0.0661"},{"v":0.0315995,"d":"0.0316"}]
["g_Roseburia","rs1258842","T","A",{"v":-0.0766573521476261,"d":"-0.0767"},{"v":0.0167780733943133,"d":"0.0168"},{"v":4.90288867520394e-06,"d":"4.90E-06"},{"v":0.0593801,"d":"0.0594"},{"v":0.0567006,"d":"0.0567"},{"v":0.294982,"d":"0.2950"}]
["g_Roseburia","rs12653554","A","T",{"v":0.141552168473842,"d":"0.1416"},{"v":0.0318370466936701,"d":"0.0318"},{"v":8.74244068658094e-06,"d":"8.74E-06"},{"v":-0.0365742,"d":"-0.0366"},{"v":0.0866871,"d":"0.0867"},{"v":0.67309,"d":"0.6731"}]
["g_Roseburia","rs13019272","A","G",{"v":0.0744020545245705,"d":"0.0744"},{"v":0.016108596984723,"d":"0.0161"},{"v":3.86004123499347e-06,"d":"3.86E-06"},{"v":-0.0935872,"d":"-0.0936"},{"v":0.0560538,"d":"0.0561"},{"v":0.0949992,"d":"0.0950"}]
["g_Roseburia","rs2210174","T","C",{"v":-0.078342581385533,"d":"-0.0783"},{"v":0.0170577188074831,"d":"0.0171"},{"v":4.37351617373128e-06,"d":"4.37E-06"},{"v":0.0400008,"d":"0.0400"},{"v":0.0562813,"d":"0.0563"},{"v":0.477252,"d":"0.4773"}]
["g_Roseburia","rs57070158","C","A",{"v":-0.112350531053836,"d":"-0.1124"},{"v":0.0249713920196531,"d":"0.0250"},{"v":6.82193757978745e-06,"d":"6.82E-06"},{"v":0.22533,"d":"0.2253"},{"v":0.0719506,"d":"0.0720"},{"v":0.00173776,"d":"0.0017"}]
["g_Roseburia","rs61217796","G","A",{"v":-0.114004963051661,"d":"-0.1140"},{"v":0.0253115110883269,"d":"0.0253"},{"v":6.66624299204009e-06,"d":"6.67E-06"},{"v":-0.0361578,"d":"-0.0362"},{"v":0.112738,"d":"0.1127"},{"v":0.748419,"d":"0.7484"}]
["g_Roseburia","rs66973779","A","G",{"v":0.083770954582632,"d":"0.0838"},{"v":0.0184651950245712,"d":"0.0185"},{"v":5.71427029006992e-06,"d":"5.71E-06"},{"v":0.0325586,"d":"0.0326"},{"v":0.056261,"d":"0.0563"},{"v":0.562787,"d":"0.5628"}]
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["s_Roseburia_unclassified","rs7289868","T","G",{"v":0.123249195185075,"d":"0.1232"},{"v":0.0263400857861625,"d":"0.0263"},{"v":2.88067563801732e-06,"d":"2.88E-06"},{"v":-0.049015,"d":"-0.0490"},{"v":0.0558094,"d":"0.0558"},{"v":0.379805,"d":"0.3798"}]
["s_Roseburia_unclassified","rs76776955","C","G",{"v":-0.207417146438158,"d":"-0.2074"},{"v":0.0451064830321944,"d":"0.0451"},{"v":4.25770864344392e-06,"d":"4.26E-06"},{"v":-0.163576,"d":"-0.1636"},{"v":0.0905793,"d":"0.0906"},{"v":0.0709365,"d":"0.0709"}]
["s_Roseburia_unclassified","rs7720468","A","G",{"v":-0.165603747888035,"d":"-0.1656"},{"v":0.0374082018830476,"d":"0.0374"},{"v":9.55806941006715e-06,"d":"9.56E-06"},{"v":0.101304,"d":"0.1013"},{"v":0.0829849,"d":"0.0830"},{"v":0.222178,"d":"0.2222"}]
["s_Roseburia_unclassified","rs8013597","G","A",{"v":0.15299569014426,"d":"0.1530"},{"v":0.0309649925336987,"d":"0.0310"},{"v":7.77530154798993e-07,"d":"7.78E-07"},{"v":-0.14968,"d":"-0.1497"},{"v":0.0632176,"d":"0.0632"},{"v":0.0178991,"d":"0.0179"}]
["s_Roseburia_unclassified","rs856250","G","A",{"v":0.177245461304903,"d":"0.1772"},{"v":0.039917623866478,"d":"0.0399"},{"v":8.98415480064333e-06,"d":"8.98E-06"},{"v":-0.132849,"d":"-0.1328"},{"v":0.067837,"d":"0.0678"},{"v":0.050188,"d":"0.0502"}]
["s_Roseburia_unclassified","rs894795","T","C",{"v":0.118868783864967,"d":"0.1189"},{"v":0.0265787888684343,"d":"0.0266"},{"v":7.73764108859105e-06,"d":"7.74E-06"},{"v":0.0207701,"d":"0.0208"},{"v":0.0555262,"d":"0.0555"},{"v":0.70836,"d":"0.7084"}]

{"sheet":"Table S4","index":3,"n_rows":38,"n_cols":12,"rows_kept":38,"merged":[[0,0,0,5],[0,6,0,9]],"flags":["formulas_cached_only"]}
["Table S4.Specific results of causality from gut microbiota to IgA nephropathy positivity"]
["Outcome","Exposure","Method","nSNP","Beta","SE","P value","OR","OR_lci95","OR_uci95","R2","F statistic"]
["IgA nephropathy","g_Roseburia","MR Egger",14,{"v":-0.012967373,"d":"-0.0130"},{"v":0.86582112,"d":"0.8658"},{"v":0.988296685,"d":"0.9883"},{"v":0.987116341,"d":"0.9871"},{"v":0.180869994,"d":"0.1809"},{"v":5.387287561,"d":"5.3873"},{"v":0.002799654,"d":"0.0028"},{"v":21.71948078,"d":"21.7195"}]
["IgA nephropathy","g_Roseburia","Weighted median",14,{"v":-0.275018016,"d":"-0.2750"},{"v":0.257058618,"d":"0.2571"},{"v":0.284680084,"d":"0.2847"},{"v":0.759558439,"d":"0.7596"},{"v":0.458932147,"d":"0.4589"},{"v":1.25711181,"d":"1.2571"},{"v":0.002799654,"d":"0.0028"},{"v":21.71948078,"d":"21.7195"}]
["IgA nephropathy","g_Roseburia","Inverse variance weighted",14,{"v":-0.448446599,"d":"-0.4484"},{"v":0.207096978,"d":"0.2071"},{"v":0.030357508,"d":"0.0304"},{"v":0.638619414,"d":"0.6386"},{"v":0.425556874,"d":"0.4256"},{"v":0.958355463,"d":"0.9584"},{"v":0.002799654,"d":"0.0028"},{"v":21.71948078,"d":"21.7195"}]
["IgA nephropathy","g_Roseburia","Simple mode",14,{"v":-0.257290859,"d":"-0.2573"},{"v":0.401430789,"d":"0.4014"},{"v":0.532701826,"d":"0.5327"},{"v":0.773143305,"d":"0.7731"},{"v":0.352010173,"d":"0.3520"},{"v":1.698105957,"d":"1.6981"},{"v":0.002799654,"d":"0.0028"},{"v":21.71948078,"d":"21.7195"}]
["IgA nephropathy","g_Roseburia","Weighted mode",14,{"v":-0.267986441,"d":"-0.2680"},{"v":0.410151274,"d":"0.4102"},{"v":0.524896998,"d":"0.5249"},{"v":0.764918152,"d":"0.7649"},{"v":0.342363261,"d":"0.3424"},{"v":1.709002823,"d":"1.7090"},{"v":0.002799654,"d":"0.0028"},{"v":21.71948078,"d":"21.7195"}]
["IgA nephropathy","g_Roseburia","BWMR",14,{"v":-0.456341690255374,"d":"-0.4563"},null,{"v":0.0385042280724385,"d":"0.0385"},{"v":0.633597306082067,"d":"0.6336"},{"v":0.411252065341886,"d":"0.4113"},{"v":0.976154480685024,"d":"0.9762"},{"v":0.002799654,"d":"0.0028"},{"v":21.71948078,"d":"21.7195"}]
["IgA nephropathy","g_Faecalibacterium","MR Egger",8,{"v":-0.63008684,"d":"-0.6301"},{"v":1.28766594,"d":"1.2877"},{"v":0.641984647,"d":"0.6420"},{"v":0.532545553,"d":"0.5325"},{"v":0.042684813,"d":"0.0427"},{"v":6.644160865,"d":"6.6442"},{"v":0.002771332,"d":"0.0028"},{"v":21.49883797,"d":"21.4988"}]
["IgA nephropathy","g_Faecalibacterium","Weighted median",8,{"v":-0.626150245,"d":"-0.6262"},{"v":0.349802436,"d":"0.3498"},{"v":0.073452126,"d":"0.0735"},{"v":0.534646101,"d":"0.5346"},{"v":0.269344777,"d":"0.2693"},{"v":1.061265994,"d":"1.0613"},{"v":0.002771332,"d":"0.0028"},{"v":21.49883797,"d":"21.4988"}]
["IgA nephropathy","g_Faecalibacterium","Inverse variance weighted",8,{"v":-0.583990976,"d":"-0.5840"},{"v":0.270025507,"d":"0.2700"},{"v":0.03056232,"d":"0.0306"},{"v":0.557668279,"d":"0.5577"},{"v":0.328492599,"d":"0.3285"},{"v":0.946730337,"d":"0.9467"},{"v":0.002771332,"d":"0.0028"},{"v":21.49883797,"d":"21.4988"}]
["IgA nephropathy","g_Faecalibacterium","Simple mode",8,{"v":-0.520703802,"d":"-0.5207"},{"v":0.569708543,"d":"0.5697"},{"v":0.391120242,"d":"0.3911"},{"v":0.59410227,"d":"0.5941"},{"v":0.194498166,"d":"0.1945"},{"v":1.814708669,"d":"1.8147"},{"v":0.002771332,"d":"0.0028"},{"v":21.49883797,"d":"21.4988"}]
["IgA nephropathy","g_Faecalibacterium","Weighted mode",8,{"v":-0.202505426,"d":"-0.2025"},{"v":0.528123508,"d":"0.5281"},{"v":0.712770771,"d":"0.7128"},{"v":0.816682051,"d":"0.8167"},{"v":0.290071596,"d":"0.2901"},{"v":2.299327412,"d":"2.2993"},{"v":0.002771332,"d":"0.0028"},{"v":21.49883797,"d":"21.4988"}]
["IgA nephropathy","g_Faecalibacterium","BWMR",8,{"v":-0.600457771326777,"d":"-0.6005"},null,{"v":0.0362099895742406,"d":"0.0362"},{"v":0.548560463357445,"d":"0.5486"},{"v":0.312753429873034,"d":"0.3128"},{"v":0.962159174660679,"d":"0.9622"},{"v":0.002771332,"d":"0.0028"},{"v":21.49883797,"d":"21.4988"}]
["IgA nephropathy","s_Odoribacter_splanchnicus","MR Egger",14,{"v":-0.67419169,"d":"-0.6742"},{"v":0.590785843,"d":"0.5908"},{"v":0.276058373,"d":"0.2761"},{"v":0.509568143,"d":"0.5096"},{"v":0.160071939,"d":"0.1601"},{"v":1.622143727,"d":"1.6221"},{"v":0.002832495,"d":"0.0028"},{"v":21.97531077,"d":"21.9753"}]
["IgA nephropathy","s_Odoribacter_splanchnicus","Weighted median",14,{"v":-0.385983845,"d":"-0.3860"},{"v":0.228659373,"d":"0.2287"},{"v":0.091405501,"d":"0.0914"},{"v":0.679781508,"d":"0.6798"},{"v":0.434240732,"d":"0.4342"},{"v":1.064162949,"d":"1.0642"},{"v":0.002832495,"d":"0.0028"},{"v":21.97531077,"d":"21.9753"}]
["IgA nephropathy","s_Odoribacter_splanchnicus","Inverse variance weighted",14,{"v":-0.39035484,"d":"-0.3904"},{"v":0.169671367,"d":"0.1697"},{"v":0.021411286,"d":"0.0214"},{"v":0.67681667,"d":"0.6768"},{"v":0.485337517,"d":"0.4853"},{"v":0.943839676,"d":"0.9438"},{"v":0.002832495,"d":"0.0028"},{"v":21.97531077,"d":"21.9753"}]
["IgA nephropathy","s_Odoribacter_splanchnicus","Simple mode",14,{"v":-0.238402812,"d":"-0.2384"},{"v":0.402943998,"d":"0.4029"},{"v":0.564230983,"d":"0.5642"},{"v":0.787885257,"d":"0.7879"},{"v":0.357659791,"d":"0.3577"},{"v":1.73562473,"d":"1.7356"},{"v":0.002832495,"d":"0.0028"},{"v":21.97531077,"d":"21.9753"}]
["IgA nephropathy","s_Odoribacter_splanchnicus","Weighted mode",14,{"v":-0.32817633,"d":"-0.3282"},{"v":0.355445181,"d":"0.3554"},{"v":0.372679577,"d":"0.3727"},{"v":0.720236009,"d":"0.7202"},{"v":0.35885069,"d":"0.3589"},{"v":1.445559182,"d":"1.4456"},{"v":0.002832495,"d":"0.0028"},{"v":21.97531077,"d":"21.9753"}]
["IgA nephropathy","s_Odoribacter_splanchnicus","BWMR",14,{"v":-0.41578755459701,"d":"-0.4158"},null,{"v":0.025368272838248,"d":"0.0254"},{"v":0.659820431413042,"d":"0.6598"},{"v":0.45827146579172,"d":"0.4583"},{"v":0.950011148867734,"d":"0.9500"},{"v":0.002832495,"d":"0.0028"},{"v":21.97531077,"d":"21.9753"}]
["IgA nephropathy","s_Paraprevotella_unclassified","MR Egger",9,{"v":-0.976302567,"d":"-0.9763"},{"v":1.670642301,"d":"1.6706"},{"v":0.577299675,"d":"0.5773"},{"v":0.376701355,"d":"0.3767"},{"v":0.014253376,"d":"0.0143"},{"v":9.955810423,"d":"9.9558"},{"v":0.002714407,"d":"0.0027"},{"v":21.2136242,"d":"21.2136"}]
["IgA nephropathy","s_Paraprevotella_unclassified","Weighted median",9,{"v":0.190444427,"d":"0.1904"},{"v":0.249844755,"d":"0.2498"},{"v":0.445910182,"d":"0.4459"},{"v":1.20978714,"d":"1.2098"},{"v":0.741373084,"d":"0.7414"},{"v":1.974154384,"d":"1.9742"},{"v":0.002714407,"d":"0.0027"},{"v":21.2136242,"d":"21.2136"}]
["IgA nephropathy","s_Paraprevotella_unclassified","Inverse variance weighted",9,{"v":0.401496188,"d":"0.4015"},{"v":0.194061045,"d":"0.1941"},{"v":0.03855388,"d":"0.0386"},{"v":1.494058418,"d":"1.4941"},{"v":1.021361498,"d":"1.0214"},{"v":2.185524479,"d":"2.1855"},{"v":0.002714407,"d":"0.0027"},{"v":21.2136242,"d":"21.2136"}]
["IgA nephropathy","s_Paraprevotella_unclassified","Simple mode",9,{"v":0.176611885,"d":"0.1766"},{"v":0.350671631,"d":"0.3507"},{"v":0.6280881,"d":"0.6281"},{"v":1.193167917,"d":"1.1932"},{"v":0.600072672,"d":"0.6001"},{"v":2.372462111,"d":"2.3725"},{"v":0.002714407,"d":"0.0027"},{"v":21.2136242,"d":"21.2136"}]
["IgA nephropathy","s_Paraprevotella_unclassified","Weighted mode",9,{"v":0.176611885,"d":"0.1766"},{"v":0.336400574,"d":"0.3364"},{"v":0.613814291,"d":"0.6138"},{"v":1.193167917,"d":"1.1932"},{"v":0.617094417,"d":"0.6171"},{"v":2.307020836,"d":"2.3070"},{"v":0.002714407,"d":"0.0027"},{"v":21.2136242,"d":"21.2136"}]
["IgA nephropathy","s_Paraprevotella_unclassified","BWMR",9,{"v":0.420463065214843,"d":"0.4205"},null,{"v":0.0283740634651322,"d":"0.0284"},{"v":1.52266648627521,"d":"1.5227"},{"v":1.04552013172048,"d":"1.0455"},{"v":2.21756918693703,"d":"2.2176"},{"v":0.002714407,"d":"0.0027"},{"v":21.2136242,"d":"21.2136"}]
["IgA nephropathy","s_Lachnospiraceae_bacterium_7_1_58FAA","MR Egger",11,{"v":0.025728038,"d":"0.0257"},{"v":1.204369573,"d":"1.2044"},{"v":0.983422807,"d":"0.9834"},{"v":1.026061861,"d":"1.0261"},{"v":0.096826329,"d":"0.0968"},{"v":10.87310601,"d":"10.8731"},{"v":0.003023114,"d":"0.0030"},{"v":23.4587508,"d":"23.4588"}]
["IgA nephropathy","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted median",11,{"v":0.595138513,"d":"0.5951"},{"v":0.28016872,"d":"0.2802"},{"v":0.033652195,"d":"0.0337"},{"v":1.813282091,"d":"1.8133"},{"v":1.047082601,"d":"1.0471"},{"v":3.140145712,"d":"3.1401"},{"v":0.003023114,"d":"0.0030"},{"v":23.4587508,"d":"23.4588"}]
["IgA nephropathy","s_Lachnospiraceae_bacterium_7_1_58FAA","Inverse variance weighted",11,{"v":0.478662083,"d":"0.4787"},{"v":0.2185611,"d":"0.2186"},{"v":0.028519832,"d":"0.0285"},{"v":1.613913674,"d":"1.6139"},{"v":1.051567941,"d":"1.0516"},{"v":2.476984363,"d":"2.4770"},{"v":0.003023114,"d":"0.0030"},{"v":23.4587508,"d":"23.4588"}]
["IgA nephropathy","s_Lachnospiraceae_bacterium_7_1_58FAA","Simple mode",11,{"v":0.561429558,"d":"0.5614"},{"v":0.456900741,"d":"0.4569"},{"v":0.247286745,"d":"0.2473"},{"v":1.753176979,"d":"1.7532"},{"v":0.715985121,"d":"0.7160"},{"v":4.292867867,"d":"4.2929"},{"v":0.003023114,"d":"0.0030"},{"v":23.4587508,"d":"23.4588"}]
["IgA nephropathy","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted mode",11,{"v":0.541647712,"d":"0.5416"},{"v":0.455031665,"d":"0.4550"},{"v":0.261398963,"d":"0.2614"},{"v":1.718836677,"d":"1.7188"},{"v":0.704537055,"d":"0.7045"},{"v":4.193391254,"d":"4.1934"},{"v":0.003023114,"d":"0.0030"},{"v":23.4587508,"d":"23.4588"}]
["IgA nephropathy","s_Lachnospiraceae_bacterium_7_1_58FAA","BWMR",11,{"v":0.498589371613551,"d":"0.4986"},null,{"v":0.0311512215702309,"d":"0.0312"},{"v":1.6463971772758,"d":"1.6464"},{"v":1.04617903872385,"d":"1.0462"},{"v":2.59097493355268,"d":"2.5910"},{"v":0.003023114,"d":"0.0030"},{"v":23.4587508,"d":"23.4588"}]
["IgA nephropathy","s_Roseburia_unclassified","MR Egger",14,{"v":-0.109392021,"d":"-0.1094"},{"v":0.632936264,"d":"0.6329"},{"v":0.865663888,"d":"0.8657"},{"v":0.896378949,"d":"0.8964"},{"v":0.259253975,"d":"0.2593"},{"v":3.099259016,"d":"3.0993"},{"v":0.002716433,"d":"0.0027"},{"v":21.07202626,"d":"21.0720"}]
["IgA nephropathy","s_Roseburia_unclassified","Weighted median",14,{"v":-0.385831026,"d":"-0.3858"},{"v":0.173331845,"d":"0.1733"},{"v":0.026016369,"d":"0.0260"},{"v":0.679885399,"d":"0.6799"},{"v":0.484052725,"d":"0.4841"},{"v":0.954945881,"d":"0.9549"},{"v":0.002716433,"d":"0.0027"},{"v":21.07202626,"d":"21.0720"}]
["IgA nephropathy","s_Roseburia_unclassified","Inverse variance weighted",14,{"v":-0.296828008,"d":"-0.2968"},{"v":0.142606421,"d":"0.1426"},{"v":0.037392817,"d":"0.0374"},{"v":0.743171821,"d":"0.7432"},{"v":0.561953264,"d":"0.5620"},{"v":0.982829695,"d":"0.9828"},{"v":0.002716433,"d":"0.0027"},{"v":21.07202626,"d":"21.0720"}]
["IgA nephropathy","s_Roseburia_unclassified","Simple mode",14,{"v":-0.449461023,"d":"-0.4495"},{"v":0.299519464,"d":"0.2995"},{"v":0.157348922,"d":"0.1573"},{"v":0.637971911,"d":"0.6380"},{"v":0.354687141,"d":"0.3547"},{"v":1.147513155,"d":"1.1475"},{"v":0.002716433,"d":"0.0027"},{"v":21.07202626,"d":"21.0720"}]
["IgA nephropathy","s_Roseburia_unclassified","Weighted mode",14,{"v":-0.443470998,"d":"-0.4435"},{"v":0.294290368,"d":"0.2943"},{"v":0.155741805,"d":"0.1557"},{"v":0.641804847,"d":"0.6418"},{"v":0.360493945,"d":"0.3605"},{"v":1.142636286,"d":"1.1426"},{"v":0.002716433,"d":"0.0027"},{"v":21.07202626,"d":"21.0720"}]
["IgA nephropathy","s_Roseburia_unclassified","BWMR",14,{"v":-0.312692977896394,"d":"-0.3127"},null,{"v":0.0351696608898626,"d":"0.0352"},{"v":0.731474456923577,"d":"0.7315"},{"v":0.546810438092405,"d":"0.5468"},{"v":0.978501586396606,"d":"0.9785"},{"v":0.002716433,"d":"0.0027"},{"v":21.07202626,"d":"21.0720"}]

{"sheet":"Table S5","index":4,"n_rows":9,"n_cols":12,"rows_kept":9,"merged":[[0,0,0,11],[1,0,2,0],[1,1,2,1],[1,2,1,5],[1,6,1,11]],"flags":["formulas_cached_only"]}
["Table S5.Results of sensitivity analysis of causal relationship between gut microbiota and IgA nephropathy"]
["Outcome","Exposure","Pleiotropy",{"$nulls":3},"Heterogenenity"]
[null,null,"MR_PRESSO_Global_Pval","MR_egger_intercept","MR_egger_se","MR_egger_Pval","IVW_Q","IVW_Q_df","IVW_Q_pval","MR_egger_Q","MR_egger_Q_df","MR_egger_Q_pval"]
["IgA nephropathy","g_Roseburia",0.191,{"v":-0.0469644628062975,"d":"-0.0470"},{"v":0.0905004598992725,"d":"0.0905"},{"v":0.613237703272962,"d":"0.6132"},{"v":17.47236277,"d":"17.4724"},13,{"v":0.178600032,"d":"0.1786"},{"v":17.08885958,"d":"17.0889"},12,{"v":0.146285174,"d":"0.1463"}]
["IgA nephropathy","g_Faecalibacterium",0.725,{"v":0.0045042841251624,"d":"0.0045"},{"v":0.123027363847522,"d":"0.1230"},{"v":0.971982038752785,"d":"0.9720"},{"v":4.579887681,"d":"4.5799"},7,{"v":0.711077323,"d":"0.7111"},{"v":4.578547239,"d":"4.5785"},6,{"v":0.598885267,"d":"0.5989"}]
["IgA nephropathy","s_Odoribacter_splanchnicus",{"v":0.38,"d":"0.380"},{"v":0.0332720993346493,"d":"0.0333"},{"v":0.0661539046350539,"d":"0.0662"},{"v":0.624103000133935,"d":"0.6241"},{"v":14.49442981,"d":"14.4944"},13,{"v":0.339967423,"d":"0.3400"},{"v":14.19519672,"d":"14.1952"},12,{"v":0.288417492,"d":"0.2884"}]
["IgA nephropathy","s_Paraprevotella_unclassified",0.623,{"v":0.158410661514102,"d":"0.1584"},{"v":0.190779703835675,"d":"0.1908"},{"v":0.433752820223265,"d":"0.4338"},{"v":6.223419426,"d":"6.2234"},8,{"v":0.622221267,"d":"0.6222"},{"v":5.53396673,"d":"5.5340"},7,{"v":0.595090064,"d":"0.5951"}]
["IgA nephropathy","s_Lachnospiraceae_bacterium_7_1_58FAA",0.392,{"v":0.0473478745059638,"d":"0.0473"},{"v":0.123612594482355,"d":"0.1236"},{"v":0.710584310504556,"d":"0.7106"},{"v":11.21396027,"d":"11.2140"},10,{"v":0.341093389,"d":"0.3411"},{"v":11.03408586,"d":"11.0341"},9,{"v":0.273379761,"d":"0.2734"}]
["IgA nephropathy","s_Roseburia_unclassified",0.161,{"v":-0.0307697922889417,"d":"-0.0308"},{"v":0.101028897679079,"d":"0.1010"},{"v":0.765915318561062,"d":"0.7659"},{"v":18.25612724,"d":"18.2561"},13,{"v":0.148034379,"d":"0.1480"},{"v":18.11609077,"d":"18.1161"},12,{"v":0.112210804,"d":"0.1122"}]

{"sheet":"Table S6","index":5,"n_rows":133,"n_cols":10,"rows_kept":133,"merged":[[0,0,0,9],[1,0,2,0],[1,1,2,1],[1,2,2,2],[1,3,2,3],[1,4,1,6],[1,7,1,9]],"flags":["formulas_cached_only"]}
["Table S6.Instrumental variables used in MR analysis of the association between circulating inflammatory proteins and IgA nephropathy."]
["exposure(Inflammatory proteins)","SNP","Effect allele","Other allele","exposure(Inflammatory proteins)",null,null,"outcome(IgA nephropathy)"]
[{"$nulls":4},"beta.exposure","se.exposure","pval.exposure","beta.outcome","se.outcome","pval.outcome"]
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["Interleukin-10 receptor subunit alpha levels","rs958402","T","C",{"v":0.06,"d":"0.0600"},0.0134,{"v":7.55e-06,"d":"7.55E-06"},{"v":-0.100265,"d":"-0.1003"},{"v":0.0562108,"d":"0.0562"},{"v":0.0744681,"d":"0.0745"}]
["Leukemia inhibitory factor levels","rs10152968","A","G",0.0678,0.0153,{"v":9.36e-06,"d":"9.36E-06"},{"v":0.165376,"d":"0.1654"},{"v":0.0657551,"d":"0.0658"},{"v":0.011902,"d":"0.0119"}]
["Leukemia inhibitory factor levels","rs11127419","T","C",0.0707,0.0153,{"v":3.82e-06,"d":"3.82E-06"},{"v":0.024521,"d":"0.0245"},{"v":0.0607244,"d":"0.0607"},{"v":0.686354,"d":"0.6864"}]
["Leukemia inhibitory factor levels","rs111417524","T","C",0.3026,0.0674,{"v":7.14e-06,"d":"7.14E-06"},{"v":-0.336789,"d":"-0.3368"},{"v":0.435415,"d":"0.4354"},{"v":0.439233,"d":"0.4392"}]
["Leukemia inhibitory factor levels","rs11442499","CT","C",-0.0707,0.0157,{"v":6.69e-06,"d":"6.69E-06"},{"v":-0.00334648,"d":"-0.0033"},{"v":0.0578175,"d":"0.0578"},{"v":0.953844,"d":"0.9538"}]
["Leukemia inhibitory factor levels","rs11608349","A","T",-0.3084,0.0661,{"v":3.08e-06,"d":"3.08E-06"},{"v":0.327231,"d":"0.3272"},{"v":0.423565,"d":"0.4236"},{"v":0.439782,"d":"0.4398"}]
["Leukemia inhibitory factor levels","rs116794364","C","G",-0.3015,0.0631,{"v":1.77e-06,"d":"1.77E-06"},{"v":-0.108533,"d":"-0.1085"},{"v":0.241052,"d":"0.2411"},{"v":0.652534,"d":"0.6525"}]
["Leukemia inhibitory factor levels","rs117844161","A","G",0.1842,0.0408,{"v":6.34e-06,"d":"6.34E-06"},0.1906,{"v":0.196024,"d":"0.1960"},{"v":0.330886,"d":"0.3309"}]
["Leukemia inhibitory factor levels","rs11883375","A","G",-0.1011,0.0197,{"v":2.87e-07,"d":"2.87E-07"},{"v":-0.142019,"d":"-0.1420"},{"v":0.0901054,"d":"0.0901"},{"v":0.114994,"d":"0.1150"}]
["Leukemia inhibitory factor levels","rs12595568","T","G",-0.0652,0.0146,{"v":7.98e-06,"d":"7.98E-06"},{"v":4.8538e-05,"d":"0.0000"},{"v":0.0612681,"d":"0.0613"},{"v":0.999368,"d":"0.9994"}]
["Leukemia inhibitory factor levels","rs13105239","A","C",0.0575,{"v":0.013,"d":"0.0130"},{"v":9.73e-06,"d":"9.73E-06"},{"v":0.0378027,"d":"0.0378"},{"v":0.0559057,"d":"0.0559"},{"v":0.498922,"d":"0.4989"}]
["Leukemia inhibitory factor levels","rs1348602","T","G",-0.0782,0.0173,{"v":6.18e-06,"d":"6.18E-06"},{"v":0.127754,"d":"0.1278"},{"v":0.230004,"d":"0.2300"},{"v":0.578591,"d":"0.5786"}]
["Leukemia inhibitory factor levels","rs145344087","C","G",0.2548,0.0556,{"v":4.59e-06,"d":"4.59E-06"},{"v":0.186731,"d":"0.1867"},{"v":0.243477,"d":"0.2435"},{"v":0.443121,"d":"0.4431"}]
["Leukemia inhibitory factor levels","rs147461732","A","G",0.2606,0.0583,{"v":7.82e-06,"d":"7.82E-06"},{"v":0.571182,"d":"0.5712"},{"v":0.420979,"d":"0.4210"},{"v":0.174847,"d":"0.1748"}]
["Leukemia inhibitory factor levels","rs1534627","T","C",{"v":0.06,"d":"0.0600"},0.0132,{"v":5.48e-06,"d":"5.48E-06"},{"v":0.0713663,"d":"0.0714"},{"v":0.0557943,"d":"0.0558"},{"v":0.200863,"d":"0.2009"}]
["Leukemia inhibitory factor levels","rs190222173","A","C",-0.3456,0.0781,{"v":9.64e-06,"d":"9.64E-06"},{"v":-0.239539,"d":"-0.2395"},{"v":0.459285,"d":"0.4593"},{"v":0.601985,"d":"0.6020"}]
["Leukemia inhibitory factor levels","rs234592","A","G",-0.0635,0.0136,{"v":3.02e-06,"d":"3.02E-06"},{"v":-0.0303117,"d":"-0.0303"},{"v":0.0572165,"d":"0.0572"},{"v":0.59627,"d":"0.5963"}]
["Leukemia inhibitory factor levels","rs332426","A","G",{"v":0.112,"d":"0.1120"},0.0238,{"v":2.53e-06,"d":"2.53E-06"},{"v":0.138368,"d":"0.1384"},{"v":0.10292,"d":"0.1029"},{"v":0.178812,"d":"0.1788"}]
["Leukemia inhibitory factor levels","rs34084384","A","AT",0.1331,0.0291,{"v":4.79e-06,"d":"4.79E-06"},{"v":0.137372,"d":"0.1374"},{"v":0.0578643,"d":"0.0579"},{"v":0.0175946,"d":"0.0176"}]
["Leukemia inhibitory factor levels","rs35337966","A","AT",-0.0783,0.0175,{"v":7.67e-06,"d":"7.67E-06"},{"v":0.0712845,"d":"0.0713"},{"v":0.839726,"d":"0.8397"},{"v":0.932349,"d":"0.9323"}]
["Leukemia inhibitory factor levels","rs4326609","A","T",-0.0707,0.0155,{"v":5.08e-06,"d":"5.08E-06"},{"v":0.029993,"d":"0.0300"},{"v":0.0665618,"d":"0.0666"},{"v":0.652275,"d":"0.6523"}]
["Leukemia inhibitory factor levels","rs4699986","T","G",0.0629,0.0139,{"v":6.03e-06,"d":"6.03E-06"},{"v":-0.0694027,"d":"-0.0694"},{"v":0.0580614,"d":"0.0581"},{"v":0.231957,"d":"0.2320"}]
["Leukemia inhibitory factor levels","rs62213023","T","C",-0.1676,0.0374,{"v":7.42e-06,"d":"7.42E-06"},{"v":-0.213443,"d":"-0.2134"},{"v":0.144008,"d":"0.1440"},{"v":0.138297,"d":"0.1383"}]
["Leukemia inhibitory factor levels","rs7225483","T","G",0.0671,0.0143,{"v":2.7e-06,"d":"2.70E-06"},{"v":0.108698,"d":"0.1087"},{"v":0.0557543,"d":"0.0558"},{"v":0.0512248,"d":"0.0512"}]
["Leukemia inhibitory factor levels","rs74992559","A","G",0.1725,0.0367,{"v":2.6e-06,"d":"2.60E-06"},{"v":-0.212765,"d":"-0.2128"},{"v":0.209945,"d":"0.2099"},{"v":0.310854,"d":"0.3109"}]
["Leukemia inhibitory factor levels","rs80092539","A","T",0.0993,0.0213,{"v":3.13e-06,"d":"3.13E-06"},{"v":0.0719687,"d":"0.0720"},{"v":0.0975001,"d":"0.0975"},{"v":0.46043,"d":"0.4604"}]
["Leukemia inhibitory factor levels","rs825264","A","G",-0.2119,0.0453,{"v":2.9e-06,"d":"2.90E-06"},{"v":-0.234394,"d":"-0.2344"},{"v":0.117242,"d":"0.1172"},{"v":0.0455837,"d":"0.0456"}]
["Leukemia inhibitory factor levels","rs9482537","C","G",0.1084,0.0243,{"v":8.16e-06,"d":"8.16E-06"},{"v":-0.0178333,"d":"-0.0178"},{"v":0.0951337,"d":"0.0951"},{"v":0.851303,"d":"0.8513"}]
["Leukemia inhibitory factor levels","rs9648464","T","C",0.0606,0.0135,{"v":7.16e-06,"d":"7.16E-06"},{"v":-0.0462274,"d":"-0.0462"},{"v":0.055924,"d":"0.0559"},{"v":0.408458,"d":"0.4085"}]
["Transforming growth factor-alpha levels","rs113302946","A","G",-0.2866,0.0637,{"v":6.82e-06,"d":"6.82E-06"},{"v":-0.58532,"d":"-0.5853"},{"v":0.669605,"d":"0.6696"},{"v":0.382049,"d":"0.3820"}]
["Transforming growth factor-alpha levels","rs12539643","C","G",0.1913,0.0407,{"v":2.6e-06,"d":"2.60E-06"},{"v":-0.0488755,"d":"-0.0489"},{"v":0.129544,"d":"0.1295"},{"v":0.705958,"d":"0.7060"}]
["Transforming growth factor-alpha levels","rs1280389","A","T",0.0574,0.0126,{"v":5.22e-06,"d":"5.22E-06"},{"v":-0.00764192,"d":"-0.0076"},{"v":0.0588787,"d":"0.0589"},{"v":0.896732,"d":"0.8967"}]
["Transforming growth factor-alpha levels","rs146328951","A","G",-0.4926,0.0993,{"v":7.02e-07,"d":"7.02E-07"},{"v":-0.285103,"d":"-0.2851"},{"v":0.692828,"d":"0.6928"},{"v":0.680702,"d":"0.6807"}]
["Transforming growth factor-alpha levels","rs151255930","T","C",-0.2518,0.0561,{"v":7.18e-06,"d":"7.18E-06"},{"v":-0.51688,"d":"-0.5169"},{"v":0.413713,"d":"0.4137"},{"v":0.211531,"d":"0.2115"}]
["Transforming growth factor-alpha levels","rs17256127","T","G",0.1205,0.0264,{"v":5.01e-06,"d":"5.01E-06"},{"v":0.0267988,"d":"0.0268"},{"v":0.0654305,"d":"0.0654"},{"v":0.682117,"d":"0.6821"}]
["Transforming growth factor-alpha levels","rs181758547","T","C",-0.3071,{"v":0.069,"d":"0.0690"},{"v":8.56e-06,"d":"8.56E-06"},{"v":-0.279387,"d":"-0.2794"},0.2929,{"v":0.340152,"d":"0.3402"}]
["Transforming growth factor-alpha levels","rs2019137","A","G",-0.0507,0.0114,{"v":8.69e-06,"d":"8.69E-06"},{"v":-0.092181,"d":"-0.0922"},{"v":0.0563292,"d":"0.0563"},{"v":0.101741,"d":"0.1017"}]
["Transforming growth factor-alpha levels","rs2283438","T","C",-0.0577,{"v":0.012,"d":"0.0120"},{"v":1.52e-06,"d":"1.52E-06"},{"v":0.0946109,"d":"0.0946"},{"v":0.0564587,"d":"0.0565"},{"v":0.0937864,"d":"0.0938"}]
["Transforming growth factor-alpha levels","rs4974444","A","G",-0.0816,0.0176,{"v":3.55e-06,"d":"3.55E-06"},{"v":-0.0941673,"d":"-0.0942"},{"v":0.0809251,"d":"0.0809"},{"v":0.244572,"d":"0.2446"}]
["Transforming growth factor-alpha levels","rs60830384","A","T",0.1138,0.0213,{"v":9.16e-08,"d":"9.16E-08"},{"v":0.115202,"d":"0.1152"},{"v":0.117751,"d":"0.1178"},0.3279]
["Transforming growth factor-alpha levels","rs62373966","T","G",0.1407,0.0273,{"v":2.55e-07,"d":"2.55E-07"},{"v":0.153124,"d":"0.1531"},{"v":0.0940962,"d":"0.0941"},{"v":0.103671,"d":"0.1037"}]
["Transforming growth factor-alpha levels","rs6917605","T","C",0.0554,0.0116,{"v":1.79e-06,"d":"1.79E-06"},{"v":-0.000973547,"d":"-0.0010"},{"v":0.0557001,"d":"0.0557"},{"v":0.986055,"d":"0.9861"}]
["Transforming growth factor-alpha levels","rs7026097","A","T",0.0832,{"v":0.016,"d":"0.0160"},{"v":1.99e-07,"d":"1.99E-07"},{"v":0.0384968,"d":"0.0385"},{"v":0.0702851,"d":"0.0703"},{"v":0.583882,"d":"0.5839"}]
["Transforming growth factor-alpha levels","rs7125631","T","C",-0.0609,0.0128,{"v":1.96e-06,"d":"1.96E-06"},{"v":-0.0703083,"d":"-0.0703"},{"v":0.062488,"d":"0.0625"},{"v":0.260527,"d":"0.2605"}]
["Transforming growth factor-alpha levels","rs7137828","T","C",-0.0622,0.0133,{"v":2.92e-06,"d":"2.92E-06"},{"v":-0.114273,"d":"-0.1143"},{"v":0.0563022,"d":"0.0563"},{"v":0.0423926,"d":"0.0424"}]
["Transforming growth factor-alpha levels","rs72823987","A","G",-0.1005,0.0223,{"v":6.58e-06,"d":"6.58E-06"},{"v":0.133284,"d":"0.1333"},{"v":0.123081,"d":"0.1231"},{"v":0.278853,"d":"0.2789"}]
["Transforming growth factor-alpha levels","rs7304709","T","C",0.0537,0.0117,{"v":4.44e-06,"d":"4.44E-06"},{"v":-0.0532767,"d":"-0.0533"},{"v":0.056792,"d":"0.0568"},{"v":0.348192,"d":"0.3482"}]
["Transforming growth factor-alpha levels","rs73072534","T","C",-0.1306,0.0294,{"v":8.91e-06,"d":"8.91E-06"},{"v":0.207877,"d":"0.2079"},{"v":0.133908,"d":"0.1339"},{"v":0.12057,"d":"0.1206"}]
["Transforming growth factor-alpha levels","rs75510105","A","G",0.1933,0.0385,{"v":5.15e-07,"d":"5.15E-07"},{"v":0.00653741,"d":"0.0065"},{"v":0.252976,"d":"0.2530"},{"v":0.979383,"d":"0.9794"}]
["Transforming growth factor-alpha levels","rs79045618","A","G",0.1619,0.0324,{"v":5.83e-07,"d":"5.83E-07"},{"v":-0.0678627,"d":"-0.0679"},{"v":0.120541,"d":"0.1205"},{"v":0.573445,"d":"0.5734"}]
["Transforming growth factor-alpha levels","rs7936674","A","G",-0.0546,0.0123,{"v":9.04e-06,"d":"9.04E-06"},{"v":0.0239246,"d":"0.0239"},{"v":0.0560811,"d":"0.0561"},{"v":0.669666,"d":"0.6697"}]
["Transforming growth factor-alpha levels","rs7945680","T","G",{"v":0.061,"d":"0.0610"},0.0114,{"v":8.75e-08,"d":"8.75E-08"},{"v":0.0968864,"d":"0.0969"},{"v":0.0561549,"d":"0.0562"},{"v":0.0844656,"d":"0.0845"}]
["Transforming growth factor-alpha levels","rs822335","T","C",-0.1295,{"v":0.012,"d":"0.0120"},{"v":3.77e-27,"d":"3.77E-27"},{"v":-0.104055,"d":"-0.1041"},{"v":0.0582565,"d":"0.0583"},{"v":0.0740764,"d":"0.0741"}]

{"sheet":"Table S7","index":6,"n_rows":32,"n_cols":12,"rows_kept":32,"merged":[[0,0,0,9]],"flags":["formulas_cached_only"]}
["Table S7.Specific results of MR analysis of circulating inflammatory proteins to IgA nephropathy"]
["Outcome","Exposure","Method","nSNP","Beta","SE","P value","OR","OR_lci95","OR_uci95","R2","F statistic"]
["IgA nephropathy","T-cell surface glycoprotein CD5 levels","MR Egger",29,{"v":0.330728248028619,"d":"0.3307"},{"v":0.463495529621462,"d":"0.4635"},{"v":0.481626989071314,"d":"0.4816"},{"v":1.39198146719739,"d":"1.3920"},{"v":0.561174713304229,"d":"0.5612"},{"v":3.45277924875164,"d":"3.4528"},{"v":0.002310288,"d":"0.0023"},{"v":31.4825283415324,"d":"31.4825"}]
["IgA nephropathy","T-cell surface glycoprotein CD5 levels","Weighted median",29,{"v":0.505771201609709,"d":"0.5058"},{"v":0.214635041941276,"d":"0.2146"},{"v":0.0184518342790844,"d":"0.0185"},{"v":1.65826388323585,"d":"1.6583"},{"v":1.08881126592598,"d":"1.0888"},{"v":2.52554248151155,"d":"2.5255"},{"v":0.002310288,"d":"0.0023"},{"v":31.4825283415324,"d":"31.4825"}]
["IgA nephropathy","T-cell surface glycoprotein CD5 levels","Inverse variance weighted",29,{"v":0.375468416085629,"d":"0.3755"},{"v":0.182337807382592,"d":"0.1823"},{"v":0.0394759218096641,"d":"0.0395"},{"v":1.45567311564866,"d":"1.4557"},{"v":1.01825086151049,"d":"1.0183"},{"v":2.08100410195473,"d":"2.0810"},{"v":0.002310288,"d":"0.0023"},{"v":31.4825283415324,"d":"31.4825"}]
["IgA nephropathy","T-cell surface glycoprotein CD5 levels","Simple mode",29,{"v":0.596104436905868,"d":"0.5961"},{"v":0.351959318181426,"d":"0.3520"},{"v":0.101425086930129,"d":"0.1014"},{"v":1.81503442940468,"d":"1.8150"},{"v":0.910523266380925,"d":"0.9105"},{"v":3.61808434947356,"d":"3.6181"},{"v":0.002310288,"d":"0.0023"},{"v":31.4825283415324,"d":"31.4825"}]
["IgA nephropathy","T-cell surface glycoprotein CD5 levels","Weighted mode",29,{"v":0.631274768185281,"d":"0.6313"},{"v":0.296913124445986,"d":"0.2969"},{"v":0.0424453350306027,"d":"0.0424"},{"v":1.88000562373405,"d":"1.8800"},{"v":1.05056177433437,"d":"1.0506"},{"v":3.36431538974569,"d":"3.3643"},{"v":0.002310288,"d":"0.0023"},{"v":31.4825283415324,"d":"31.4825"}]
["IgA nephropathy","T-cell surface glycoprotein CD5 levels","BWMR",29,{"v":0.432702683982444,"d":"0.4327"},null,{"v":0.0102771031062813,"d":"0.0103"},{"v":1.54141786434485,"d":"1.5414"},{"v":1.10764502369521,"d":"1.1076"},{"v":2.14506360945402,"d":"2.1451"},{"v":0.002310288,"d":"0.0023"},{"v":31.4825283415324,"d":"31.4825"}]
["IgA nephropathy","Fibroblast growth factor 23 levels","MR Egger",28,{"v":0.646400367163888,"d":"0.6464"},{"v":0.336068115567144,"d":"0.3361"},{"v":0.0654424685698471,"d":"0.0654"},{"v":1.90865798064232,"d":"1.9087"},{"v":0.987782112613216,"d":"0.9878"},{"v":3.68803528688326,"d":"3.6880"},{"v":0.001865741,"d":"0.0019"},{"v":24.5872610985124,"d":"24.5873"}]
["IgA nephropathy","Fibroblast growth factor 23 levels","Weighted median",28,{"v":0.379769641565861,"d":"0.3798"},{"v":0.262084524701198,"d":"0.2621"},{"v":0.147327816716241,"d":"0.1473"},{"v":1.46194777864103,"d":"1.4619"},{"v":0.874663509771009,"d":"0.8747"},{"v":2.44355833254436,"d":"2.4436"},{"v":0.001865741,"d":"0.0019"},{"v":24.5872610985124,"d":"24.5873"}]
["IgA nephropathy","Fibroblast growth factor 23 levels","Inverse variance weighted",28,{"v":0.387625985964924,"d":"0.3876"},{"v":0.178217276366198,"d":"0.1782"},{"v":0.0296286826244937,"d":"0.0296"},{"v":1.47347857954628,"d":"1.4735"},{"v":1.03906380920403,"d":"1.0391"},{"v":2.08951472002947,"d":"2.0895"},{"v":0.001865741,"d":"0.0019"},{"v":24.5872610985124,"d":"24.5873"}]
["IgA nephropathy","Fibroblast growth factor 23 levels","Simple mode",28,{"v":0.446097324547843,"d":"0.4461"},{"v":0.425301165127461,"d":"0.4253"},{"v":0.303524012521848,"d":"0.3035"},{"v":1.5622034998846,"d":"1.5622"},{"v":0.678756413289277,"d":"0.6788"},{"v":3.59551634028038,"d":"3.5955"},{"v":0.001865741,"d":"0.0019"},{"v":24.5872610985124,"d":"24.5873"}]
["IgA nephropathy","Fibroblast growth factor 23 levels","Weighted mode",28,{"v":0.433455570067012,"d":"0.4335"},{"v":0.311518401142275,"d":"0.3115"},{"v":0.175454802818448,"d":"0.1755"},{"v":1.54257881338177,"d":"1.5426"},{"v":0.837678841347864,"d":"0.8377"},{"v":2.84064641249085,"d":"2.8406"},{"v":0.001865741,"d":"0.0019"},{"v":24.5872610985124,"d":"24.5873"}]
["IgA nephropathy","Fibroblast growth factor 23 levels","BWMR",28,{"v":0.398034209086936,"d":"0.3980"},null,{"v":0.0373677071464577,"d":"0.0374"},{"v":1.48889496277331,"d":"1.4889"},{"v":1.02354704623838,"d":"1.0235"},{"v":2.16580978697432,"d":"2.1658"},{"v":0.001865741,"d":"0.0019"},{"v":24.5872610985124,"d":"24.5873"}]
["IgA nephropathy","Interleukin-10 receptor subunit alpha levels","MR Egger",19,{"v":-0.501978097796944,"d":"-0.5020"},{"v":0.357113204471274,"d":"0.3571"},{"v":0.177839576638585,"d":"0.1778"},{"v":0.605332068606917,"d":"0.6053"},{"v":0.300616480276394,"d":"0.3006"},{"v":1.21891824741953,"d":"1.2189"},{"v":0.001930064,"d":"0.0019"},{"v":21.4971003244045,"d":"21.4971"}]
["IgA nephropathy","Interleukin-10 receptor subunit alpha levels","Weighted median",19,{"v":-0.361388811833846,"d":"-0.3614"},{"v":0.265030354772059,"d":"0.2650"},{"v":0.172701310349691,"d":"0.1727"},{"v":0.696708057460274,"d":"0.6967"},{"v":0.414431197558424,"d":"0.4144"},{"v":1.17124897978184,"d":"1.1712"},{"v":0.001930064,"d":"0.0019"},{"v":21.4971003244045,"d":"21.4971"}]
["IgA nephropathy","Interleukin-10 receptor subunit alpha levels","Inverse variance weighted",19,{"v":-0.525965762546384,"d":"-0.5260"},{"v":0.193859109112865,"d":"0.1939"},{"v":0.00666501256738531,"d":"0.0067"},{"v":0.590984338134054,"d":"0.5910"},{"v":0.404165991074764,"d":"0.4042"},{"v":0.864156053781225,"d":"0.8642"},{"v":0.001930064,"d":"0.0019"},{"v":21.4971003244045,"d":"21.4971"}]
["IgA nephropathy","Interleukin-10 receptor subunit alpha levels","Simple mode",19,{"v":-0.272875671609709,"d":"-0.2729"},{"v":0.42470805916842,"d":"0.4247"},{"v":0.528646980065754,"d":"0.5286"},{"v":0.76118741895264,"d":"0.7612"},{"v":0.331110385726628,"d":"0.3311"},{"v":1.74988859229004,"d":"1.7499"},{"v":0.001930064,"d":"0.0019"},{"v":21.4971003244045,"d":"21.4971"}]
["IgA nephropathy","Interleukin-10 receptor subunit alpha levels","Weighted mode",19,{"v":-0.310802104311639,"d":"-0.3108"},{"v":0.30531057931331,"d":"0.3053"},{"v":0.322172819597684,"d":"0.3222"},{"v":0.732858891134644,"d":"0.7329"},{"v":0.402842005518339,"d":"0.4028"},{"v":1.33323274871505,"d":"1.3332"},{"v":0.001930064,"d":"0.0019"},{"v":21.4971003244045,"d":"21.4971"}]
["IgA nephropathy","Interleukin-10 receptor subunit alpha levels","BWMR",19,{"v":-0.545966125960126,"d":"-0.5460"},null,{"v":0.00586361759021391,"d":"0.0059"},{"v":0.579281853665046,"d":"0.5793"},{"v":0.392844718686302,"d":"0.3928"},{"v":0.854198745773575,"d":"0.8542"},{"v":0.001930064,"d":"0.0019"},{"v":21.4971003244045,"d":"21.4971"}]
["IgA nephropathy","Leukemia inhibitory factor levels","MR Egger",26,{"v":0.891609940035373,"d":"0.8916"},{"v":0.393961655950384,"d":"0.3940"},{"v":0.0329485921195053,"d":"0.0329"},{"v":2.43905322151574,"d":"2.4391"},{"v":1.12687137078904,"d":"1.1269"},{"v":5.27920113297478,"d":"5.2792"},{"v":0.00200266,"d":"0.0020"},{"v":20.9935916729394,"d":"20.9936"}]
["IgA nephropathy","Leukemia inhibitory factor levels","Weighted median",26,{"v":0.729277379179486,"d":"0.7293"},{"v":0.234889940510057,"d":"0.2349"},{"v":0.00190432139652054,"d":"0.0019"},{"v":2.07358165287597,"d":"2.0736"},{"v":1.30851524776679,"d":"1.3085"},{"v":3.28596925292395,"d":"3.2860"},{"v":0.00200266,"d":"0.0020"},{"v":20.9935916729394,"d":"20.9936"}]
["IgA nephropathy","Leukemia inhibitory factor levels","Inverse variance weighted",26,{"v":0.630458693120837,"d":"0.6305"},{"v":0.170777031526867,"d":"0.1708"},{"v":0.000222754351985998,"d":"0.0002"},{"v":1.87847202387492,"d":"1.8785"},{"v":1.34411487555048,"d":"1.3441"},{"v":2.62526455786421,"d":"2.6253"},{"v":0.00200266,"d":"0.0020"},{"v":20.9935916729394,"d":"20.9936"}]
["IgA nephropathy","Leukemia inhibitory factor levels","Simple mode",26,{"v":0.877231415331557,"d":"0.8772"},{"v":0.450243313086993,"d":"0.4502"},{"v":0.062682591645418,"d":"0.0627"},{"v":2.40423415777841,"d":"2.4042"},{"v":0.994768255179033,"d":"0.9948"},{"v":5.81074220586998,"d":"5.8107"},{"v":0.00200266,"d":"0.0020"},{"v":20.9935916729394,"d":"20.9936"}]
["IgA nephropathy","Leukemia inhibitory factor levels","Weighted mode",26,{"v":0.962586160988041,"d":"0.9626"},{"v":0.370038861208286,"d":"0.3700"},{"v":0.0153792247980337,"d":"0.0154"},{"v":2.61845948230077,"d":"2.6185"},{"v":1.2678340765789,"d":"1.2678"},{"v":5.40790801186841,"d":"5.4079"},{"v":0.00200266,"d":"0.0020"},{"v":20.9935916729394,"d":"20.9936"}]
["IgA nephropathy","Leukemia inhibitory factor levels","BWMR",26,{"v":0.642290281621401,"d":"0.6423"},null,{"v":0.000489341370448204,"d":"0.0005"},{"v":1.90082933229837,"d":"1.9008"},{"v":1.32474169911539,"d":"1.3247"},{"v":2.72743898145472,"d":"2.7274"},{"v":0.00200266,"d":"0.0020"},{"v":20.9935916729394,"d":"20.9936"}]
["IgA nephropathy","Transforming growth factor-alpha levels","MR Egger",27,{"v":0.467422442592938,"d":"0.4674"},{"v":0.403252830775945,"d":"0.4033"},{"v":0.257355314951801,"d":"0.2574"},{"v":1.59587542679219,"d":"1.5959"},{"v":0.724007805390873,"d":"0.7240"},{"v":3.51766701805677,"d":"3.5177"},{"v":0.001773426,"d":"0.0018"},{"v":23.771670494519,"d":"23.7717"}]
["IgA nephropathy","Transforming growth factor-alpha levels","Weighted median",27,{"v":0.42218271294592,"d":"0.4222"},{"v":0.248104580543694,"d":"0.2481"},{"v":0.0888243602818625,"d":"0.0888"},{"v":1.52528718894039,"d":"1.5253"},{"v":0.937909079429469,"d":"0.9379"},{"v":2.48051869820993,"d":"2.4805"},{"v":0.001773426,"d":"0.0018"},{"v":23.771670494519,"d":"23.7717"}]
["IgA nephropathy","Transforming growth factor-alpha levels","Inverse variance weighted",27,{"v":0.493188265157587,"d":"0.4932"},{"v":0.176364087630086,"d":"0.1764"},{"v":0.00516720175115211,"d":"0.0052"},{"v":1.63752878198509,"d":"1.6375"},{"v":1.15895026727021,"d":"1.1590"},{"v":2.3137321656999,"d":"2.3137"},{"v":0.001773426,"d":"0.0018"},{"v":23.771670494519,"d":"23.7717"}]
["IgA nephropathy","Transforming growth factor-alpha levels","Simple mode",27,{"v":0.388049565282568,"d":"0.3880"},{"v":0.435177136435304,"d":"0.4352"},{"v":0.380729611931313,"d":"0.3807"},{"v":1.47410284680158,"d":"1.4741"},{"v":0.628199415615315,"d":"0.6282"},{"v":3.4590595739732,"d":"3.4591"},{"v":0.001773426,"d":"0.0018"},{"v":23.771670494519,"d":"23.7717"}]
["IgA nephropathy","Transforming growth factor-alpha levels","Weighted mode",27,{"v":0.34407943145137,"d":"0.3441"},{"v":0.392942197173217,"d":"0.3929"},{"v":0.389239078867638,"d":"0.3892"},{"v":1.41069068426601,"d":"1.4107"},{"v":0.653059343873901,"d":"0.6531"},{"v":3.04727009167356,"d":"3.0473"},{"v":0.001773426,"d":"0.0018"},{"v":23.771670494519,"d":"23.7717"}]
["IgA nephropathy","Transforming growth factor-alpha levels","BWMR",27,{"v":0.506788674610316,"d":"0.5068"},null,{"v":0.00612694051923234,"d":"0.0061"},{"v":1.65995198061604,"d":"1.6600"},{"v":1.15533296577877,"d":"1.1553"},{"v":2.38497529246365,"d":"2.3850"},{"v":0.001773426,"d":"0.0018"},{"v":23.771670494519,"d":"23.7717"}]

{"sheet":"Table S8","index":7,"n_rows":8,"n_cols":12,"rows_kept":8,"merged":[[0,0,0,9],[1,0,2,0],[1,1,2,1],[1,2,1,5],[1,6,1,11]],"flags":["formulas_cached_only"]}
["Table S8.Sensitivity analysis of circulating inflammatory proteins to causality of IgA nephropathy"]
["Outcome","Exposure","Pleiotropy",{"$nulls":3},"Heterogenenity"]
[null,null,"MR_PRESSO_Global_Pval","MR_egger_intercept","MR_egger_se","MR_egger_Pval","IVW_Q","IVW_Q_df","IVW_Q_pval","MR_egger_Q","MR_egger_Q_df","MR_egger_Q_pval"]
["IgA nephropathy","T-cell surface glycoprotein CD5 levels",0.069,{"v":0.00485722526412184,"d":"0.0049"},{"v":0.0461068391376526,"d":"0.0461"},{"v":0.916879084719436,"d":"0.9169"},{"v":40.3965858695685,"d":"40.3966"},28,{"v":0.0609342217779782,"d":"0.0609"},{"v":40.3799881579936,"d":"40.3800"},27,{"v":0.0471899043402611,"d":"0.0472"}]
["IgA nephropathy","Fibroblast growth factor 23 levels",0.179,{"v":-0.029756653717793,"d":"-0.0298"},{"v":0.0327219887541555,"d":"0.0327"},{"v":0.37150397974306,"d":"0.3715"},{"v":33.8854715979261,"d":"33.8855"},27,{"v":0.169401985873071,"d":"0.1694"},{"v":32.8409179739632,"d":"32.8409"},26,{"v":0.166763508224259,"d":"0.1668"}]
["IgA nephropathy","Interleukin-10 receptor subunit alpha levels",0.247,{"v":-0.00310686749512594,"d":"-0.0031"},{"v":0.0383677335874751,"d":"0.0384"},{"v":0.936406696917576,"d":"0.9364"},{"v":22.2409947197286,"d":"22.2410"},18,{"v":0.22146129640475,"d":"0.2215"},{"v":22.2324193870771,"d":"22.2324"},17,{"v":0.175945190590603,"d":"0.1759"}]
["IgA nephropathy","Leukemia inhibitory factor levels",0.542,{"v":-0.0263878416220274,"d":"-0.0264"},{"v":0.0358729978155624,"d":"0.0359"},{"v":0.469108262389005,"d":"0.4691"},{"v":24.1260097524173,"d":"24.1260"},25,{"v":0.512102336612637,"d":"0.5121"},{"v":23.584916154553,"d":"23.5849"},24,{"v":0.485526623364354,"d":"0.4855"}]
["IgA nephropathy","Transforming growth factor-alpha levels",0.328,{"v":0.00275379562378846,"d":"0.0028"},{"v":0.0387582977890604,"d":"0.0388"},{"v":0.943922915769288,"d":"0.9439"},{"v":21.2169312980532,"d":"21.2169"},26,{"v":0.730681278889316,"d":"0.7307"},{"v":21.2118831274847,"d":"21.2119"},25,{"v":0.680737340655942,"d":"0.6807"}]

{"sheet":"Table S9","index":8,"n_rows":32,"n_cols":12,"rows_kept":32,"merged":[[0,0,0,9]],"flags":["formulas_cached_only"]}
["Table S9. Specific results of inverse MR analysis of IgA nephropathy to gut microbiota"]
["Outcome","Exposure","Method","nSNP","Beta","SE","P value","OR","OR_lci95","OR_uci95","R2","F statistic"]
["g_Roseburia","IgA nephropathy","MR Egger",6,{"v":0.0894154830754556,"d":"0.0894"},{"v":0.0910177392480959,"d":"0.0910"},{"v":0.381525385299487,"d":"0.3815"},{"v":1.09353490719938,"d":"1.0935"},{"v":0.914864524018417,"d":"0.9149"},{"v":1.30709909704564,"d":"1.3071"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Roseburia","IgA nephropathy","Weighted median",6,{"v":-0.00578915167138162,"d":"-0.0058"},{"v":0.0300368386126568,"d":"0.0300"},{"v":0.847166470060062,"d":"0.8472"},{"v":0.994227573177363,"d":"0.9942"},{"v":0.937384849996121,"d":"0.9374"},{"v":1.05451722125682,"d":"1.0545"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Roseburia","IgA nephropathy","Inverse variance weighted",6,{"v":-0.0141458961830303,"d":"-0.0141"},{"v":0.0238651356309856,"d":"0.0239"},{"v":0.553353044654745,"d":"0.5534"},{"v":0.985953686889434,"d":"0.9860"},{"v":0.94089703894499,"d":"0.9409"},{"v":1.03316795829315,"d":"1.0332"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Roseburia","IgA nephropathy","Simple mode",6,{"v":-0.0123049513638313,"d":"-0.0123"},{"v":0.0452077771120101,"d":"0.0452"},{"v":0.796360711064267,"d":"0.7964"},{"v":0.98777044498389,"d":"0.9878"},{"v":0.904012406659412,"d":"0.9040"},{"v":1.07928878497269,"d":"1.0793"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Roseburia","IgA nephropathy","Weighted mode",6,{"v":0.0101839549049893,"d":"0.0102"},{"v":0.0401432181549965,"d":"0.0401"},{"v":0.809836200388712,"d":"0.8098"},{"v":1.01023598785749,"d":"1.0102"},{"v":0.933796492435742,"d":"0.9338"},{"v":1.09293273152086,"d":"1.0929"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Faecalibacterium","IgA nephropathy","MR Egger",6,{"v":-0.0599219587545165,"d":"-0.0599"},{"v":0.0911134071532789,"d":"0.0911"},{"v":0.546676006612909,"d":"0.5467"},{"v":0.941838032929355,"d":"0.9418"},{"v":0.787805350496101,"d":"0.7878"},{"v":1.12598737710227,"d":"1.1260"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Faecalibacterium","IgA nephropathy","Weighted median",6,{"v":-0.00143816452713875,"d":"-0.0014"},{"v":0.030881420093744,"d":"0.0309"},{"v":0.962855509188917,"d":"0.9629"},{"v":0.99856286913588,"d":"0.9986"},{"v":0.939915080294837,"d":"0.9399"},{"v":1.06087009829026,"d":"1.0609"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Faecalibacterium","IgA nephropathy","Inverse variance weighted",6,{"v":0.0170722560511012,"d":"0.0171"},{"v":0.023885678418946,"d":"0.0239"},{"v":0.474764379388941,"d":"0.4748"},{"v":1.01721881988492,"d":"1.0172"},{"v":0.970694316193376,"d":"0.9707"},{"v":1.06597320110601,"d":"1.0660"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Faecalibacterium","IgA nephropathy","Simple mode",6,{"v":0.000440379690919646,"d":"0.0004"},{"v":0.0466016357371145,"d":"0.0466"},{"v":0.992825655646027,"d":"0.9928"},{"v":1.00044047667229,"d":"1.0004"},{"v":0.913110088903131,"d":"0.9131"},{"v":1.0961231942652,"d":"1.0961"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["g_Faecalibacterium","IgA nephropathy","Weighted mode",6,{"v":-0.0108236030126329,"d":"-0.0108"},{"v":0.0403744921345336,"d":"0.0404"},{"v":0.799345715982026,"d":"0.7993"},{"v":0.989234761417523,"d":"0.9892"},{"v":0.913969929832203,"d":"0.9140"},{"v":1.07069760312185,"d":"1.0707"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["s_Odoribacter_splanchnicus","IgA nephropathy","MR Egger",6,{"v":0.0826960775390653,"d":"0.0827"},{"v":0.103852085346449,"d":"0.1039"},{"v":0.4704516541244,"d":"0.4705"},{"v":1.08621163426411,"d":"1.0862"},{"v":0.886163321363578,"d":"0.8862"},{"v":1.33142016371791,"d":"1.3314"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["s_Odoribacter_splanchnicus","IgA nephropathy","Weighted median",6,{"v":-0.0340382025389772,"d":"-0.0340"},{"v":0.0354717355408518,"d":"0.0355"},{"v":0.337263309582385,"d":"0.3373"},{"v":0.966534579857241,"d":"0.9665"},{"v":0.901619395479681,"d":"0.9016"},{"v":1.03612355584121,"d":"1.0361"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["s_Odoribacter_splanchnicus","IgA nephropathy","Inverse variance weighted",6,{"v":-0.0385898255215717,"d":"-0.0386"},{"v":0.0271742061575319,"d":"0.0272"},{"v":0.155581405135753,"d":"0.1556"},{"v":0.962145275656893,"d":"0.9621"},{"v":0.912240817406359,"d":"0.9122"},{"v":1.01477977503885,"d":"1.0148"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["s_Odoribacter_splanchnicus","IgA nephropathy","Simple mode",6,{"v":-0.0428750169823637,"d":"-0.0429"},{"v":0.047040888889546,"d":"0.0470"},{"v":0.403864223933039,"d":"0.4039"},{"v":0.958031120205151,"d":"0.9580"},{"v":0.87365024636166,"d":"0.8737"},{"v":1.05056185939835,"d":"1.0506"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["s_Odoribacter_splanchnicus","IgA nephropathy","Weighted mode",6,{"v":-0.0452147711917916,"d":"-0.0452"},{"v":0.0473478392721412,"d":"0.0473"},{"v":0.383459017245763,"d":"0.3835"},{"v":0.955792183161486,"d":"0.9558"},{"v":0.871084287233034,"d":"0.8711"},{"v":1.04873743078804,"d":"1.0487"},{"v":5.47201666e-05,"d":"0.0001"},{"v":22.5557292988249,"d":"22.5557"}]
["s_Paraprevotella_unclassified","IgA nephropathy","MR Egger",6,{"v":-0.0736623348454584,"d":"-0.0737"},{"v":0.124336661655436,"d":"0.1243"},{"v":0.585422505349434,"d":"0.5854"},{"v":0.928985326860797,"d":"0.9290"},{"v":0.728067007545016,"d":"0.7281"},{"v":1.18534932716245,"d":"1.1853"},{"v":5.47201666e-05,"d":"0.0001"},{"v":23.5557292988249,"d":"23.5557"}]
["s_Paraprevotella_unclassified","IgA nephropathy","Weighted median",6,{"v":-0.00561825338481816,"d":"-0.0056"},{"v":0.0429159533277624,"d":"0.0429"},{"v":0.895844182534064,"d":"0.8958"},{"v":0.994397499485717,"d":"0.9944"},{"v":0.914174760362672,"d":"0.9142"},{"v":1.08166012655081,"d":"1.0817"},{"v":5.47201666e-05,"d":"0.0001"},{"v":24.5557292988249,"d":"24.5557"}]
["s_Paraprevotella_unclassified","IgA nephropathy","Inverse variance weighted",6,{"v":0.0317104280874707,"d":"0.0317"},{"v":0.0326623795660752,"d":"0.0327"},{"v":0.331620587557386,"d":"0.3316"},{"v":1.03221856052148,"d":"1.0322"},{"v":0.968208486905161,"d":"0.9682"},{"v":1.10046045980323,"d":"1.1005"},{"v":5.47201666e-05,"d":"0.0001"},{"v":25.5557292988249,"d":"25.5557"}]
["s_Paraprevotella_unclassified","IgA nephropathy","Simple mode",6,{"v":-0.00661447769368731,"d":"-0.0066"},{"v":0.0720338332801973,"d":"0.0720"},{"v":0.930402863211743,"d":"0.9304"},{"v":0.993407349811528,"d":"0.9934"},{"v":0.862602936162143,"d":"0.8626"},{"v":1.14404683926796,"d":"1.1440"},{"v":5.47201666e-05,"d":"0.0001"},{"v":26.5557292988249,"d":"26.5557"}]
["s_Paraprevotella_unclassified","IgA nephropathy","Weighted mode",6,{"v":-0.0168108522759364,"d":"-0.0168"},{"v":0.0547001483461745,"d":"0.0547"},{"v":0.770982795759522,"d":"0.7710"},{"v":0.983329661613292,"d":"0.9833"},{"v":0.883359397029238,"d":"0.8834"},{"v":1.09461361554578,"d":"1.0946"},{"v":5.47201666e-05,"d":"0.0001"},{"v":27.5557292988249,"d":"27.5557"}]
["s_Lachnospiraceae_bacterium_7_1_58FAA","IgA nephropathy","MR Egger",6,{"v":-0.0162309268859536,"d":"-0.0162"},{"v":0.0930121043835558,"d":"0.0930"},{"v":0.869946172795739,"d":"0.8699"},{"v":0.983900084836253,"d":"0.9839"},{"v":0.819931358414943,"d":"0.8199"},{"v":1.18065904786493,"d":"1.1807"},{"v":5.47201666e-05,"d":"0.0001"},{"v":28.5557292988249,"d":"28.5557"}]
["s_Lachnospiraceae_bacterium_7_1_58FAA","IgA nephropathy","Weighted median",6,{"v":0.0189716495226292,"d":"0.0190"},{"v":0.029209180409228,"d":"0.0292"},{"v":0.516008900948058,"d":"0.5160"},{"v":1.01915275474072,"d":"1.0192"},{"v":0.962445012733723,"d":"0.9624"},{"v":1.07920174529801,"d":"1.0792"},{"v":5.47201666e-05,"d":"0.0001"},{"v":29.5557292988249,"d":"29.5557"}]
["s_Lachnospiraceae_bacterium_7_1_58FAA","IgA nephropathy","Inverse variance weighted",6,{"v":0.0237639597933241,"d":"0.0238"},{"v":0.0243661244038269,"d":"0.0244"},{"v":0.329418010304708,"d":"0.3294"},{"v":1.0240485727242,"d":"1.0240"},{"v":0.976291915012329,"d":"0.9763"},{"v":1.07414131283186,"d":"1.0741"},{"v":5.47201666e-05,"d":"0.0001"},{"v":30.5557292988249,"d":"30.5557"}]
["s_Lachnospiraceae_bacterium_7_1_58FAA","IgA nephropathy","Simple mode",6,{"v":0.016844004700775,"d":"0.0168"},{"v":0.0394924306653561,"d":"0.0395"},{"v":0.687474390719772,"d":"0.6875"},{"v":1.01698666481156,"d":"1.0170"},{"v":0.941236201813547,"d":"0.9412"},{"v":1.09883350684107,"d":"1.0988"},{"v":5.47201666e-05,"d":"0.0001"},{"v":31.5557292988249,"d":"31.5557"}]
["s_Lachnospiraceae_bacterium_7_1_58FAA","IgA nephropathy","Weighted mode",6,{"v":0.0192629628162894,"d":"0.0193"},{"v":0.0393197366578614,"d":"0.0393"},{"v":0.644938105756135,"d":"0.6449"},{"v":1.01944969073505,"d":"1.0194"},{"v":0.943835184252029,"d":"0.9438"},{"v":1.10112198536378,"d":"1.1011"},{"v":5.47201666e-05,"d":"0.0001"},{"v":32.5557292988249,"d":"32.5557"}]
["s_Roseburia_unclassified","IgA nephropathy","MR Egger",6,{"v":-0.0274672521117593,"d":"-0.0275"},{"v":0.216937959018962,"d":"0.2169"},{"v":0.905355768576081,"d":"0.9054"},{"v":0.972906542666503,"d":"0.9729"},{"v":0.635930720384161,"d":"0.6359"},{"v":1.48844380436832,"d":"1.4884"},{"v":5.47201666e-05,"d":"0.0001"},{"v":33.5557292988249,"d":"33.5557"}]
["s_Roseburia_unclassified","IgA nephropathy","Weighted median",6,{"v":-0.0476792662931492,"d":"-0.0477"},{"v":0.0562458976290834,"d":"0.0562"},{"v":0.39660884103849,"d":"0.3966"},{"v":0.95343953823989,"d":"0.9534"},{"v":0.853917046082648,"d":"0.8539"},{"v":1.06456119742469,"d":"1.0646"},{"v":5.47201666e-05,"d":"0.0001"},{"v":34.5557292988249,"d":"34.5557"}]
["s_Roseburia_unclassified","IgA nephropathy","Inverse variance weighted",6,{"v":-0.0636119987399595,"d":"-0.0636"},{"v":0.0511064768468263,"d":"0.0511"},{"v":0.213243722404586,"d":"0.2132"},{"v":0.938369017267575,"d":"0.9384"},{"v":0.84892817705326,"d":"0.8489"},{"v":1.03723310919443,"d":"1.0372"},{"v":5.47201666e-05,"d":"0.0001"},{"v":35.5557292988249,"d":"35.5557"}]
["s_Roseburia_unclassified","IgA nephropathy","Simple mode",6,{"v":-0.0507949768082562,"d":"-0.0508"},{"v":0.0838690789827209,"d":"0.0839"},{"v":0.571187332290837,"d":"0.5712"},{"v":0.950473519672119,"d":"0.9505"},{"v":0.806397588908443,"d":"0.8064"},{"v":1.12029093839525,"d":"1.1203"},{"v":5.47201666e-05,"d":"0.0001"},{"v":36.5557292988249,"d":"36.5557"}]
["s_Roseburia_unclassified","IgA nephropathy","Weighted mode",6,{"v":-0.0978530905242758,"d":"-0.0979"},{"v":0.0698539276712533,"d":"0.0699"},{"v":0.220171927042346,"d":"0.2202"},{"v":0.906782108853343,"d":"0.9068"},{"v":0.790755241137189,"d":"0.7908"},{"v":1.03983350366926,"d":"1.0398"},{"v":5.47201666e-05,"d":"0.0001"},{"v":37.5557292988249,"d":"37.5557"}]

{"sheet":"Table S10","index":9,"n_rows":27,"n_cols":12,"rows_kept":27,"merged":[[0,0,0,9]],"flags":["formulas_cached_only"]}
["Table S10 .Specific results of inverse MR analysis of IgA nephropathy to circulating inflammatory proteins"]
["Outcome","Exposure","Method","nSNP","Beta","SE","P value","OR","OR_lci95","OR_uci95","R2","F statistic"]
["T-cell surface glycoprotein CD5 levels","IgA nephropathy","MR Egger",13,{"v":-0.0316216854104814,"d":"-0.0316"},{"v":0.0386836561044383,"d":"0.0387"},{"v":0.431025061657499,"d":"0.4310"},{"v":0.968873051565249,"d":"0.9689"},{"v":0.898128925509679,"d":"0.8981"},{"v":1.04518957511211,"d":"1.0452"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["T-cell surface glycoprotein CD5 levels","IgA nephropathy","Weighted median",13,{"v":-0.018050226242614,"d":"-0.0181"},{"v":0.0170014114050905,"d":"0.0170"},{"v":0.288376500201569,"d":"0.2884"},{"v":0.982111703338819,"d":"0.9821"},{"v":0.949924289718438,"d":"0.9499"},{"v":1.01538976134716,"d":"1.0154"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["T-cell surface glycoprotein CD5 levels","IgA nephropathy","Inverse variance weighted",13,{"v":-0.017069292706068,"d":"-0.0171"},{"v":0.0134652930679079,"d":"0.0135"},{"v":0.204922597716466,"d":"0.2049"},{"v":0.983075562308765,"d":"0.9831"},{"v":0.957469638930186,"d":"0.9575"},{"v":1.00936627326223,"d":"1.0094"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["T-cell surface glycoprotein CD5 levels","IgA nephropathy","Simple mode",13,{"v":0.00958600156165001,"d":"0.0096"},{"v":0.0273676450690087,"d":"0.0274"},{"v":0.732209122962725,"d":"0.7322"},{"v":1.00963209443902,"d":"1.0096"},{"v":0.956901725697324,"d":"0.9569"},{"v":1.06526818663483,"d":"1.0653"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["T-cell surface glycoprotein CD5 levels","IgA nephropathy","Weighted mode",13,{"v":-0.0174607906471106,"d":"-0.0175"},{"v":0.0259547099027122,"d":"0.0260"},{"v":0.513858825309287,"d":"0.5139"},{"v":0.98269076557871,"d":"0.9827"},{"v":0.933950329983644,"d":"0.9340"},{"v":1.03397483758112,"d":"1.0340"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Fibroblast growth factor 23 levels","IgA nephropathy","MR Egger",13,{"v":0.0202886862559101,"d":"0.0203"},{"v":0.0395624144351879,"d":"0.0396"},{"v":0.618213320215753,"d":"0.6182"},{"v":1.02049590064764,"d":"1.0205"},{"v":0.94435450720748,"d":"0.9444"},{"v":1.10277642060306,"d":"1.1028"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Fibroblast growth factor 23 levels","IgA nephropathy","Weighted median",13,{"v":-0.00116780773533608,"d":"-0.0012"},{"v":0.0163571077359735,"d":"0.0164"},{"v":0.94308377673011,"d":"0.9431"},{"v":0.998832873886757,"d":"0.9988"},{"v":0.967318238512641,"d":"0.9673"},{"v":1.03137423676711,"d":"1.0314"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Fibroblast growth factor 23 levels","IgA nephropathy","Inverse variance weighted",13,{"v":-0.00175804258438373,"d":"-0.0018"},{"v":0.0138118958895956,"d":"0.0138"},{"v":0.898715094671697,"d":"0.8987"},{"v":0.998243501867277,"d":"0.9982"},{"v":0.971582242545941,"d":"0.9716"},{"v":1.02563637475407,"d":"1.0256"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Fibroblast growth factor 23 levels","IgA nephropathy","Simple mode",13,{"v":-0.012276389692059,"d":"-0.0123"},{"v":0.0291048716742062,"d":"0.0291"},{"v":0.680629955393031,"d":"0.6806"},{"v":0.987798657762026,"d":"0.9878"},{"v":0.933026254953289,"d":"0.9330"},{"v":1.04578642143925,"d":"1.0458"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Fibroblast growth factor 23 levels","IgA nephropathy","Weighted mode",13,{"v":-0.00375943710575363,"d":"-0.0038"},{"v":0.022544492877534,"d":"0.0225"},{"v":0.870338703204406,"d":"0.8703"},{"v":0.996247620730655,"d":"0.9962"},{"v":0.953184644654879,"d":"0.9532"},{"v":1.0412560959486,"d":"1.0413"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Interleukin-10 receptor subunit alpha levels","IgA nephropathy","MR Egger",13,{"v":-0.0358456976871802,"d":"-0.0358"},{"v":0.0455241892419461,"d":"0.0455"},{"v":0.447682518773884,"d":"0.4477"},{"v":0.964789151195696,"d":"0.9648"},{"v":0.88243238682867,"d":"0.8824"},{"v":1.05483221168948,"d":"1.0548"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Interleukin-10 receptor subunit alpha levels","IgA nephropathy","Weighted median",13,{"v":0.0169947106979008,"d":"0.0170"},{"v":0.0209285208044366,"d":"0.0209"},{"v":0.416771019238658,"d":"0.4168"},{"v":1.01713994235058,"d":"1.0171"},{"v":0.976261117353698,"d":"0.9763"},{"v":1.05973047982215,"d":"1.0597"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Interleukin-10 receptor subunit alpha levels","IgA nephropathy","Inverse variance weighted",13,{"v":0.0134475305285299,"d":"0.0134"},{"v":0.0167273587474474,"d":"0.0167"},{"v":0.421440682851995,"d":"0.4214"},{"v":1.01353835523321,"d":"1.0135"},{"v":0.980847688816329,"d":"0.9808"},{"v":1.04731856866433,"d":"1.0473"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Interleukin-10 receptor subunit alpha levels","IgA nephropathy","Simple mode",13,{"v":0.0247387712105463,"d":"0.0247"},{"v":0.0365935976673783,"d":"0.0366"},{"v":0.511833776179906,"d":"0.5118"},{"v":1.02504731367764,"d":"1.0250"},{"v":0.954102014113734,"d":"0.9541"},{"v":1.10126797735959,"d":"1.1013"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Interleukin-10 receptor subunit alpha levels","IgA nephropathy","Weighted mode",13,{"v":0.0145997822191044,"d":"0.0146"},{"v":0.0323598995992096,"d":"0.0324"},{"v":0.659912545199979,"d":"0.6599"},{"v":1.01470687960429,"d":"1.0147"},{"v":0.952347184573973,"d":"0.9523"},{"v":1.08114988755585,"d":"1.0811"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Leukemia inhibitory factor levels","IgA nephropathy","MR Egger",13,{"v":0.00420853960855431,"d":"0.0042"},{"v":0.0523380616587767,"d":"0.0523"},{"v":0.937354951799061,"d":"0.9374"},{"v":1.00421740794793,"d":"1.0042"},{"v":0.906309824960408,"d":"0.9063"},{"v":1.1127018318153,"d":"1.1127"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Leukemia inhibitory factor levels","IgA nephropathy","Weighted median",13,{"v":0.0126703573815176,"d":"0.0127"},{"v":0.0220589669401637,"d":"0.0221"},{"v":0.56570675961955,"d":"0.5657"},{"v":1.0127509664484,"d":"1.0128"},{"v":0.96989717542393,"d":"0.9699"},{"v":1.05749820293461,"d":"1.0575"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Leukemia inhibitory factor levels","IgA nephropathy","Inverse variance weighted",13,{"v":0.0179813245583139,"d":"0.0180"},{"v":0.0181713418354163,"d":"0.0182"},{"v":0.322397530371534,"d":"0.3224"},{"v":1.01814396192405,"d":"1.0181"},{"v":0.982520072483163,"d":"0.9825"},{"v":1.05505949062448,"d":"1.0551"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Leukemia inhibitory factor levels","IgA nephropathy","Simple mode",13,{"v":0.0158958347321098,"d":"0.0159"},{"v":0.0351436980128472,"d":"0.0351"},{"v":0.659113669438911,"d":"0.6591"},{"v":1.01602284560188,"d":"1.0160"},{"v":0.948393466891158,"d":"0.9484"},{"v":1.08847483541703,"d":"1.0885"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Leukemia inhibitory factor levels","IgA nephropathy","Weighted mode",13,{"v":0.0211213274941982,"d":"0.0211"},{"v":0.0361853318264136,"d":"0.0362"},{"v":0.570232027054703,"d":"0.5702"},{"v":1.02134596146676,"d":"1.0213"},{"v":0.951417859942036,"d":"0.9514"},{"v":1.09641369678304,"d":"1.0964"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Transforming growth factor-alpha levels","IgA nephropathy","MR Egger",13,{"v":-0.0380331818813938,"d":"-0.0380"},{"v":0.0344173820404167,"d":"0.0344"},{"v":0.292719224061591,"d":"0.2927"},{"v":0.962680996794564,"d":"0.9627"},{"v":0.8998823461704,"d":"0.8999"},{"v":1.02986207645181,"d":"1.0299"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Transforming growth factor-alpha levels","IgA nephropathy","Weighted median",13,{"v":0.0244514009356398,"d":"0.0245"},{"v":0.0167180219371545,"d":"0.0167"},{"v":0.143583053041646,"d":"0.1436"},{"v":1.02475278787032,"d":"1.0248"},{"v":0.991718559570293,"d":"0.9917"},{"v":1.05888738908245,"d":"1.0589"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Transforming growth factor-alpha levels","IgA nephropathy","Inverse variance weighted",13,{"v":0.0147631349271915,"d":"0.0148"},{"v":0.0124810127128085,"d":"0.0125"},{"v":0.236869583816173,"d":"0.2369"},{"v":1.01487264826,"d":"1.0149"},{"v":0.990347239887454,"d":"0.9903"},{"v":1.04000541497275,"d":"1.0400"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Transforming growth factor-alpha levels","IgA nephropathy","Simple mode",13,{"v":0.0322000325074497,"d":"0.0322"},{"v":0.0257905844541138,"d":"0.0258"},{"v":0.23565068300681,"d":"0.2357"},{"v":1.03272406302913,"d":"1.0327"},{"v":0.981817814270278,"d":"0.9818"},{"v":1.08626974868252,"d":"1.0863"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]
["Transforming growth factor-alpha levels","IgA nephropathy","Weighted mode",13,{"v":0.0230039259682057,"d":"0.0230"},{"v":0.0248124947455393,"d":"0.0248"},{"v":0.372140663982101,"d":"0.3721"},{"v":1.023270556867,"d":"1.0233"},{"v":0.974697060217535,"d":"0.9747"},{"v":1.07426468724264,"d":"1.0743"},{"v":5.90255e-05,"d":"0.0001"},{"v":24.33057866,"d":"24.3306"}]

{"sheet":"Table S11","index":10,"n_rows":153,"n_cols":15,"rows_kept":153,"merged":[[0,0,0,9],[6,13,6,14]],"flags":["formulas_cached_only"]}
["Table S11.Analytical results of Mendelian randomisation analysis of positive gut flora to positive circulating inflammatory proteins and results of mediation analysis"]
["Outcome","Exposure","Method","nSNP","Beta","SE","P value","OR","OR_lci95","OR_uci95","R2","F statistic",null,"beta_all","beta_direct"]
["T-cell surface glycoprotein CD5 levels","s_Odoribacter_splanchnicus","MR Egger",14,{"v":0.0819128431184895,"d":"0.0819"},{"v":0.135387522966419,"d":"0.1354"},{"v":0.556430956471038,"d":"0.5564"},{"v":1.08536120900876,"d":"1.0854"},{"v":0.832396239697236,"d":"0.8324"},{"v":1.41520215714746,"d":"1.4152"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["T-cell surface glycoprotein CD5 levels","s_Odoribacter_splanchnicus","Weighted median",14,{"v":0.0675375485304248,"d":"0.0675"},{"v":0.047714464632206,"d":"0.0477"},{"v":0.156935925660122,"d":"0.1569"},{"v":1.06987043090614,"d":"1.0699"},{"v":0.974351846222826,"d":"0.9744"},{"v":1.17475298411403,"d":"1.1748"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["T-cell surface glycoprotein CD5 levels","s_Odoribacter_splanchnicus","Inverse variance weighted",14,{"v":0.0747903271616329,"d":"0.0748"},{"v":0.0364545896297328,"d":"0.0365"},{"v":0.0402083091968656,"d":"0.0402"},{"v":1.07765817154698,"d":"1.0777"},{"v":1.00334491326616,"d":"1.0033"},{"v":1.15747547961496,"d":"1.1575"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"},"positive",{"v":-0.39035484,"d":"-0.3904"},{"v":-0.418436246,"d":"-0.4184"}]
["T-cell surface glycoprotein CD5 levels","s_Odoribacter_splanchnicus","Simple mode",14,{"v":0.067656480836589,"d":"0.0677"},{"v":0.0795301484740407,"d":"0.0795"},{"v":0.410330470975911,"d":"0.4103"},{"v":1.06999768063068,"d":"1.0700"},{"v":0.915557041725275,"d":"0.9156"},{"v":1.25049012172699,"d":"1.2505"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"},null,"The direct effect exceeded the total effect, suggesting a role of nonmediation and ruling out this result"]
["T-cell surface glycoprotein CD5 levels","s_Odoribacter_splanchnicus","Weighted mode",14,{"v":0.0644139830828813,"d":"0.0644"},{"v":0.0760167202281146,"d":"0.0760"},{"v":0.412120246965938,"d":"0.4121"},{"v":1.06653383434651,"d":"1.0665"},{"v":0.918899253771789,"d":"0.9189"},{"v":1.23788806567947,"d":"1.2379"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Interleukin-10 receptor subunit alpha levels","s_Roseburia_unclassified","MR Egger",14,{"v":0.126741746699393,"d":"0.1267"},{"v":0.116470340336768,"d":"0.1165"},{"v":0.297884464146467,"d":"0.2979"},{"v":1.13512383044901,"d":"1.1351"},{"v":0.903444932078577,"d":"0.9034"},{"v":1.42621433216602,"d":"1.4262"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Interleukin-10 receptor subunit alpha levels","s_Roseburia_unclassified","Weighted median",14,{"v":-0.0660694719824682,"d":"-0.0661"},{"v":0.040778579390392,"d":"0.0408"},{"v":0.105189228470051,"d":"0.1052"},{"v":0.936065831683625,"d":"0.9361"},{"v":0.864161602629344,"d":"0.8642"},{"v":1.01395299048179,"d":"1.0140"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Interleukin-10 receptor subunit alpha levels","s_Roseburia_unclassified","Inverse variance weighted",14,{"v":-0.0592720274737459,"d":"-0.0593"},{"v":0.0285430921281559,"d":"0.0285"},{"v":0.0378402976065783,"d":"0.0378"},{"v":0.942450361892694,"d":"0.9425"},{"v":0.891173194679373,"d":"0.8912"},{"v":0.996677963312431,"d":"0.9967"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"},"positive",{"v":-0.296828,"d":"-0.2968"},{"v":-0.3280031,"d":"-0.3280"}]
["Interleukin-10 receptor subunit alpha levels","s_Roseburia_unclassified","Simple mode",14,{"v":-0.0580768233267453,"d":"-0.0581"},{"v":0.0738727588068156,"d":"0.0739"},{"v":0.445860128437625,"d":"0.4459"},{"v":0.94357745589311,"d":"0.9436"},{"v":0.816386462125238,"d":"0.8164"},{"v":1.09058449224153,"d":"1.0906"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"},null,"The direct effect exceeded the total effect, suggesting a role of nonmediation and ruling out this result"]
["Interleukin-10 receptor subunit alpha levels","s_Roseburia_unclassified","Weighted mode",14,{"v":-0.0567624889511777,"d":"-0.0568"},{"v":0.0698637718792458,"d":"0.0699"},{"v":0.431147342289384,"d":"0.4311"},{"v":0.944818447539743,"d":"0.9448"},{"v":0.823908761255901,"d":"0.8239"},{"v":1.08347178812697,"d":"1.0835"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Transforming growth factor-alpha levels","s_Odoribacter_splanchnicus","MR Egger",14,{"v":-0.109599952896327,"d":"-0.1096"},{"v":0.135684313989711,"d":"0.1357"},{"v":0.434950720749581,"d":"0.4350"},{"v":0.896192582840896,"d":"0.8962"},{"v":0.686917412755255,"d":"0.6869"},{"v":1.16922519450704,"d":"1.1692"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Transforming growth factor-alpha levels","s_Odoribacter_splanchnicus","Weighted median",14,{"v":-0.0884084932384803,"d":"-0.0884"},{"v":0.049546941610702,"d":"0.0495"},{"v":0.0743687507061066,"d":"0.0744"},{"v":0.915386870991726,"d":"0.9154"},{"v":0.830671807634921,"d":"0.8307"},{"v":1.00874149800482,"d":"1.0087"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Transforming growth factor-alpha levels","s_Odoribacter_splanchnicus","Inverse variance weighted",14,{"v":-0.0849621828900243,"d":"-0.0850"},{"v":0.0366789942088959,"d":"0.0367"},{"v":0.0205379844668433,"d":"0.0205"},{"v":0.918547020538337,"d":"0.9185"},{"v":0.85482969968516,"d":"0.8548"},{"v":0.98701370489421,"d":"0.9870"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"},"positive",{"v":-0.3903548,"d":"-0.3904"},{"v":-0.3484525,"d":"-0.3485"}]
["Transforming growth factor-alpha levels","s_Odoribacter_splanchnicus","Simple mode",14,{"v":-0.128832747576664,"d":"-0.1288"},{"v":0.0883792505096091,"d":"0.0884"},{"v":0.168647211665089,"d":"0.1686"},{"v":0.879120988365989,"d":"0.8791"},{"v":0.739296605026558,"d":"0.7393"},{"v":1.04539058739196,"d":"1.0454"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"},null,"The direct effect did not exceed the total effect, and mediation played a role and was included in this result"]
["Transforming growth factor-alpha levels","s_Odoribacter_splanchnicus","Weighted mode",14,{"v":-0.123839662417446,"d":"-0.1238"},{"v":0.0867257192575179,"d":"0.0867"},{"v":0.176888112557211,"d":"0.1769"},{"v":0.883521491226548,"d":"0.8835"},{"v":0.745409108675787,"d":"0.7454"},{"v":1.04722388869909,"d":"1.0472"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
[]
["T-cell surface glycoprotein CD5 levels","g_Roseburia","MR Egger",14,{"v":-0.151798073988961,"d":"-0.1518"},{"v":0.172786042065378,"d":"0.1728"},{"v":0.396905364417643,"d":"0.3969"},{"v":0.859161750331605,"d":"0.8592"},{"v":0.612345436832406,"d":"0.6123"},{"v":1.20546160521956,"d":"1.2055"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["T-cell surface glycoprotein CD5 levels","g_Roseburia","Weighted median",14,{"v":-0.0349394460813002,"d":"-0.0349"},{"v":0.0573728745797147,"d":"0.0574"},{"v":0.54253176978607,"d":"0.5425"},{"v":0.965663889219804,"d":"0.9657"},{"v":0.862957116559827,"d":"0.8630"},{"v":1.08059453830168,"d":"1.0806"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["T-cell surface glycoprotein CD5 levels","g_Roseburia","Inverse variance weighted",14,{"v":-0.0331287817622276,"d":"-0.0331"},{"v":0.0405436855678342,"d":"0.0405"},{"v":0.413863724535607,"d":"0.4139"},{"v":0.967413966291149,"d":"0.9674"},{"v":0.89351299060826,"d":"0.8935"},{"v":1.04742716895259,"d":"1.0474"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["T-cell surface glycoprotein CD5 levels","g_Roseburia","Simple mode",14,{"v":-0.0057187144690059,"d":"-0.0057"},{"v":0.0948234307451856,"d":"0.0948"},{"v":0.952826755150081,"d":"0.9528"},{"v":0.99429760625258,"d":"0.9943"},{"v":0.825659648060289,"d":"0.8257"},{"v":1.197379249576,"d":"1.1974"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["T-cell surface glycoprotein CD5 levels","g_Roseburia","Weighted mode",14,{"v":-0.0210809684029213,"d":"-0.0211"},{"v":0.0968533421055464,"d":"0.0969"},{"v":0.831074200364295,"d":"0.8311"},{"v":0.979139681983524,"d":"0.9791"},{"v":0.809844100037434,"d":"0.8098"},{"v":1.18382601884792,"d":"1.1838"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["T-cell surface glycoprotein CD5 levels","g_Faecalibacterium","MR Egger",8,{"v":0.077420014074723,"d":"0.0774"},{"v":0.246897141328051,"d":"0.2469"},{"v":0.764461249712926,"d":"0.7645"},{"v":1.08049580454541,"d":"1.0805"},{"v":0.665978172549678,"d":"0.6660"},{"v":1.75301718849224,"d":"1.7530"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["T-cell surface glycoprotein CD5 levels","g_Faecalibacterium","Weighted median",8,{"v":-0.0356018417819486,"d":"-0.0356"},{"v":0.0682830573074241,"d":"0.0683"},{"v":0.602097783210809,"d":"0.6021"},{"v":0.965024449415783,"d":"0.9650"},{"v":0.84414024248808,"d":"0.8441"},{"v":1.10321975081455,"d":"1.1032"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["T-cell surface glycoprotein CD5 levels","g_Faecalibacterium","Inverse variance weighted",8,{"v":0.00574065679152078,"d":"0.0057"},{"v":0.0549850104538572,"d":"0.0550"},{"v":0.916848723089291,"d":"0.9168"},{"v":1.00575716593772,"d":"1.0058"},{"v":0.903002493969446,"d":"0.9030"},{"v":1.12020452168241,"d":"1.1202"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["T-cell surface glycoprotein CD5 levels","g_Faecalibacterium","Simple mode",8,{"v":-0.0509996288394044,"d":"-0.0510"},{"v":0.103193461429707,"d":"0.1032"},{"v":0.636285140858341,"d":"0.6363"},{"v":0.95027902323849,"d":"0.9503"},{"v":0.776266947657554,"d":"0.7763"},{"v":1.16329855951237,"d":"1.1633"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["T-cell surface glycoprotein CD5 levels","g_Faecalibacterium","Weighted mode",8,{"v":-0.0492033922572214,"d":"-0.0492"},{"v":0.0984140453299997,"d":"0.0984"},{"v":0.632431820167962,"d":"0.6324"},{"v":0.951987483123027,"d":"0.9520"},{"v":0.78498166268931,"d":"0.7850"},{"v":1.15452399858366,"d":"1.1545"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["T-cell surface glycoprotein CD5 levels","s_Paraprevotella_unclassified","MR Egger",9,{"v":-0.298772939989609,"d":"-0.2988"},{"v":0.33012918821854,"d":"0.3301"},{"v":0.395535717807915,"d":"0.3955"},{"v":0.74172780703968,"d":"0.7417"},{"v":0.388358596307258,"d":"0.3884"},{"v":1.41662923124952,"d":"1.4166"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["T-cell surface glycoprotein CD5 levels","s_Paraprevotella_unclassified","Weighted median",9,{"v":-0.00530170649354134,"d":"-0.0053"},{"v":0.0510271150650816,"d":"0.0510"},{"v":0.917248874478208,"d":"0.9172"},{"v":0.994712322748406,"d":"0.9947"},{"v":0.900041098211392,"d":"0.9000"},{"v":1.0993415822831,"d":"1.0993"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["T-cell surface glycoprotein CD5 levels","s_Paraprevotella_unclassified","Inverse variance weighted",9,{"v":-0.0254575953006694,"d":"-0.0255"},{"v":0.0393079209063469,"d":"0.0393"},{"v":0.517214307330791,"d":"0.5172"},{"v":0.974863716892077,"d":"0.9749"},{"v":0.902577138615851,"d":"0.9026"},{"v":1.05293966116853,"d":"1.0529"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["T-cell surface glycoprotein CD5 levels","s_Paraprevotella_unclassified","Simple mode",9,{"v":0.0327147557683085,"d":"0.0327"},{"v":0.0769361887212262,"d":"0.0769"},{"v":0.681883681753417,"d":"0.6819"},{"v":1.03325576695487,"d":"1.0333"},{"v":0.88862480504209,"d":"0.8886"},{"v":1.20142660196722,"d":"1.2014"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["T-cell surface glycoprotein CD5 levels","s_Paraprevotella_unclassified","Weighted mode",9,{"v":0.0372028855808147,"d":"0.0372"},{"v":0.073974666677621,"d":"0.0740"},{"v":0.628575475300092,"d":"0.6286"},{"v":1.03790357514789,"d":"1.0379"},{"v":0.897818397481421,"d":"0.8978"},{"v":1.19984602044988,"d":"1.1998"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["T-cell surface glycoprotein CD5 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","MR Egger",11,{"v":0.0668324955922042,"d":"0.0668"},{"v":0.337935929095123,"d":"0.3379"},{"v":0.847622196503402,"d":"0.8476"},{"v":1.06911638146893,"d":"1.0691"},{"v":0.551274766447583,"d":"0.5513"},{"v":2.07339407985384,"d":"2.0734"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["T-cell surface glycoprotein CD5 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted median",11,{"v":-0.0817288543465927,"d":"-0.0817"},{"v":0.0671887706575581,"d":"0.0672"},{"v":0.223830126139765,"d":"0.2238"},{"v":0.921521791452558,"d":"0.9215"},{"v":0.807817716070135,"d":"0.8078"},{"v":1.05123024071956,"d":"1.0512"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["T-cell surface glycoprotein CD5 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Inverse variance weighted",11,{"v":-0.0120969256662177,"d":"-0.0121"},{"v":0.0614931346960934,"d":"0.0615"},{"v":0.844046706423934,"d":"0.8440"},{"v":0.987975947994002,"d":"0.9880"},{"v":0.875794793335676,"d":"0.8758"},{"v":1.11452646355312,"d":"1.1145"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["T-cell surface glycoprotein CD5 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Simple mode",11,{"v":-0.0603558514510739,"d":"-0.0604"},{"v":0.112817598752468,"d":"0.1128"},{"v":0.604350951959861,"d":"0.6044"},{"v":0.941429464929272,"d":"0.9414"},{"v":0.754667257813344,"d":"0.7547"},{"v":1.17441087878259,"d":"1.1744"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["T-cell surface glycoprotein CD5 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted mode",11,{"v":-0.0655392808732177,"d":"-0.0655"},{"v":0.101052160728426,"d":"0.1011"},{"v":0.531227697699349,"d":"0.5312"},{"v":0.936562257053787,"d":"0.9366"},{"v":0.76827962588196,"d":"0.7683"},{"v":1.14170522266648,"d":"1.1417"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["T-cell surface glycoprotein CD5 levels","s_Roseburia_unclassified","MR Egger",14,{"v":0.0132967776342199,"d":"0.0133"},{"v":0.103542334837284,"d":"0.1035"},{"v":0.899944720556884,"d":"0.8999"},{"v":1.01338557290914,"d":"1.0134"},{"v":0.827251764967519,"d":"0.8273"},{"v":1.24139997382866,"d":"1.2414"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["T-cell surface glycoprotein CD5 levels","s_Roseburia_unclassified","Weighted median",14,{"v":0.025214253863421,"d":"0.0252"},{"v":0.034146317871356,"d":"0.0341"},{"v":0.460260513286116,"d":"0.4603"},{"v":1.02553482178531,"d":"1.0255"},{"v":0.95914546729355,"d":"0.9591"},{"v":1.09651946087166,"d":"1.0965"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["T-cell surface glycoprotein CD5 levels","s_Roseburia_unclassified","Inverse variance weighted",14,{"v":0.0207892472734488,"d":"0.0208"},{"v":0.0254062712736022,"d":"0.0254"},{"v":0.413201736302931,"d":"0.4132"},{"v":1.0210068489838,"d":"1.0210"},{"v":0.971409621422406,"d":"0.9714"},{"v":1.07313636048343,"d":"1.0731"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["T-cell surface glycoprotein CD5 levels","s_Roseburia_unclassified","Simple mode",14,{"v":0.0259181048069065,"d":"0.0259"},{"v":0.0562938226414672,"d":"0.0563"},{"v":0.652830301413728,"d":"0.6528"},{"v":1.02625689952494,"d":"1.0263"},{"v":0.919047209375078,"d":"0.9190"},{"v":1.14597293052952,"d":"1.1460"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["T-cell surface glycoprotein CD5 levels","s_Roseburia_unclassified","Weighted mode",14,{"v":0.0295809707104185,"d":"0.0296"},{"v":0.0588028483505455,"d":"0.0588"},{"v":0.62334148447406,"d":"0.6233"},{"v":1.03002283377603,"d":"1.0300"},{"v":0.917894689688896,"d":"0.9179"},{"v":1.15584832336224,"d":"1.1558"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Fibroblast growth factor 23 levels","g_Roseburia","MR Egger",14,{"v":-0.0680171721387837,"d":"-0.0680"},{"v":0.170789870344297,"d":"0.1708"},{"v":0.697440058649894,"d":"0.6974"},{"v":0.934244430464449,"d":"0.9342"},{"v":0.668468958539857,"d":"0.6685"},{"v":1.30568913440698,"d":"1.3057"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Fibroblast growth factor 23 levels","g_Roseburia","Weighted median",14,{"v":0.0269873641930378,"d":"0.0270"},{"v":0.0550892010595649,"d":"0.0551"},{"v":0.624215394458679,"d":"0.6242"},{"v":1.02735482122427,"d":"1.0274"},{"v":0.922205246711199,"d":"0.9222"},{"v":1.14449351969832,"d":"1.1445"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Fibroblast growth factor 23 levels","g_Roseburia","Inverse variance weighted",14,{"v":0.0526305505556095,"d":"0.0526"},{"v":0.0401623552307273,"d":"0.0402"},{"v":0.1900453981527,"d":"0.1900"},{"v":1.05404015862503,"d":"1.0540"},{"v":0.974249677588288,"d":"0.9742"},{"v":1.14036543357604,"d":"1.1404"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Fibroblast growth factor 23 levels","g_Roseburia","Simple mode",14,{"v":0.0161656624752688,"d":"0.0162"},{"v":0.0955006980243331,"d":"0.0955"},{"v":0.868187707909126,"d":"0.8682"},{"v":1.01629703374343,"d":"1.0163"},{"v":0.842808336512879,"d":"0.8428"},{"v":1.22549767966125,"d":"1.2255"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Fibroblast growth factor 23 levels","g_Roseburia","Weighted mode",14,{"v":0.0130033627223535,"d":"0.0130"},{"v":0.080648526392604,"d":"0.0806"},{"v":0.874387112280257,"d":"0.8744"},{"v":1.01308827408867,"d":"1.0131"},{"v":0.86496369069437,"d":"0.8650"},{"v":1.18657911556036,"d":"1.1866"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Fibroblast growth factor 23 levels","g_Faecalibacterium","MR Egger",8,{"v":-0.101468690901751,"d":"-0.1015"},{"v":0.246280067417636,"d":"0.2463"},{"v":0.694650284796624,"d":"0.6947"},{"v":0.903509466966058,"d":"0.9035"},{"v":0.557564201275108,"d":"0.5576"},{"v":1.46409930018894,"d":"1.4641"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Fibroblast growth factor 23 levels","g_Faecalibacterium","Weighted median",8,{"v":0.0466484162979384,"d":"0.0466"},{"v":0.0700237820663184,"d":"0.0700"},{"v":0.505296299876864,"d":"0.5053"},{"v":1.04775357123566,"d":"1.0478"},{"v":0.913384638274954,"d":"0.9134"},{"v":1.20188965309334,"d":"1.2019"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Fibroblast growth factor 23 levels","g_Faecalibacterium","Inverse variance weighted",8,{"v":0.0424705791013933,"d":"0.0425"},{"v":0.0547162672138513,"d":"0.0547"},{"v":0.437632929210653,"d":"0.4376"},{"v":1.04338535858726,"d":"1.0434"},{"v":0.937279916305598,"d":"0.9373"},{"v":1.16150254323737,"d":"1.1615"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Fibroblast growth factor 23 levels","g_Faecalibacterium","Simple mode",8,{"v":0.0444685581727876,"d":"0.0445"},{"v":0.103050163030584,"d":"0.1031"},{"v":0.679066480007311,"d":"0.6791"},{"v":1.04547210464041,"d":"1.0455"},{"v":0.854268474739548,"d":"0.8543"},{"v":1.27947121297492,"d":"1.2795"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Fibroblast growth factor 23 levels","g_Faecalibacterium","Weighted mode",8,{"v":0.0418011233834546,"d":"0.0418"},{"v":0.105200034444722,"d":"0.1052"},{"v":0.702947598215437,"d":"0.7029"},{"v":1.04268709204828,"d":"1.0427"},{"v":0.848410276021669,"d":"0.8484"},{"v":1.28145120662864,"d":"1.2815"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Fibroblast growth factor 23 levels","s_Odoribacter_splanchnicus","MR Egger",14,{"v":0.0672617810163534,"d":"0.0673"},{"v":0.135541782447785,"d":"0.1355"},{"v":0.628687082568922,"d":"0.6287"},{"v":1.06957543607389,"d":"1.0696"},{"v":0.820041678496046,"d":"0.8200"},{"v":1.3950408173774,"d":"1.3950"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Fibroblast growth factor 23 levels","s_Odoribacter_splanchnicus","Weighted median",14,{"v":-0.00125248082356492,"d":"-0.0013"},{"v":0.0469217985835734,"d":"0.0469"},{"v":0.978704643013711,"d":"0.9787"},{"v":0.998748303203181,"d":"0.9987"},{"v":0.910993783060965,"d":"0.9110"},{"v":1.0949560707205,"d":"1.0950"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Fibroblast growth factor 23 levels","s_Odoribacter_splanchnicus","Inverse variance weighted",14,{"v":-0.0232600103547397,"d":"-0.0233"},{"v":0.0361004104071584,"d":"0.0361"},{"v":0.519371650043255,"d":"0.5194"},{"v":0.977008418439438,"d":"0.9770"},{"v":0.910267456189853,"d":"0.9103"},{"v":1.04864283921235,"d":"1.0486"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Fibroblast growth factor 23 levels","s_Odoribacter_splanchnicus","Simple mode",14,{"v":-0.00866576592628104,"d":"-0.0087"},{"v":0.0829859190027632,"d":"0.0830"},{"v":0.918426360246463,"d":"0.9184"},{"v":0.991371673597826,"d":"0.9914"},{"v":0.842553457970381,"d":"0.8426"},{"v":1.16647529710418,"d":"1.1665"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Fibroblast growth factor 23 levels","s_Odoribacter_splanchnicus","Weighted mode",14,{"v":-0.00358250414974859,"d":"-0.0036"},{"v":0.0812337518417983,"d":"0.0812"},{"v":0.965493966855254,"d":"0.9655"},{"v":0.996423905361924,"d":"0.9964"},{"v":0.849760564706814,"d":"0.8498"},{"v":1.168400418204,"d":"1.1684"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Fibroblast growth factor 23 levels","s_Paraprevotella_unclassified","MR Egger",9,{"v":-0.278713858901974,"d":"-0.2787"},{"v":0.314079364578982,"d":"0.3141"},{"v":0.404321099768457,"d":"0.4043"},{"v":0.756756411348114,"d":"0.7568"},{"v":0.408889874998662,"d":"0.4089"},{"v":1.40057336004798,"d":"1.4006"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Fibroblast growth factor 23 levels","s_Paraprevotella_unclassified","Weighted median",9,{"v":0.0852916264510221,"d":"0.0853"},{"v":0.0542959274471434,"d":"0.0543"},{"v":0.116213777216348,"d":"0.1162"},{"v":1.08903461169274,"d":"1.0890"},{"v":0.979093249399721,"d":"0.9791"},{"v":1.21132117517088,"d":"1.2113"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Fibroblast growth factor 23 levels","s_Paraprevotella_unclassified","Inverse variance weighted",9,{"v":0.0583961080692117,"d":"0.0584"},{"v":0.0381969939909897,"d":"0.0382"},{"v":0.126310502940872,"d":"0.1263"},{"v":1.06013484051762,"d":"1.0601"},{"v":0.983664888744068,"d":"0.9837"},{"v":1.14254955416197,"d":"1.1425"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Fibroblast growth factor 23 levels","s_Paraprevotella_unclassified","Simple mode",9,{"v":0.10172905655134,"d":"0.1017"},{"v":0.075258216967296,"d":"0.0753"},{"v":0.213434859520756,"d":"0.2134"},{"v":1.10708347407415,"d":"1.1071"},{"v":0.955254913771417,"d":"0.9553"},{"v":1.28304372047582,"d":"1.2830"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Fibroblast growth factor 23 levels","s_Paraprevotella_unclassified","Weighted mode",9,{"v":0.0979639229450072,"d":"0.0980"},{"v":0.0755229218379292,"d":"0.0755"},{"v":0.230738437993031,"d":"0.2307"},{"v":1.10292299417723,"d":"1.1029"},{"v":0.95117139760656,"d":"0.9512"},{"v":1.27888531356788,"d":"1.2789"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Fibroblast growth factor 23 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","MR Egger",11,{"v":0.330308784644192,"d":"0.3303"},{"v":0.225804731025345,"d":"0.2258"},{"v":0.177546107963185,"d":"0.1775"},{"v":1.39139770438222,"d":"1.3914"},{"v":0.893804249418907,"d":"0.8938"},{"v":2.16600846663995,"d":"2.1660"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Fibroblast growth factor 23 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted median",11,{"v":-0.0236690316674221,"d":"-0.0237"},{"v":0.0576294663273469,"d":"0.0576"},{"v":0.681284766467994,"d":"0.6813"},{"v":0.976608882888474,"d":"0.9766"},{"v":0.872299207842,"d":"0.8723"},{"v":1.09339192511273,"d":"1.0934"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Fibroblast growth factor 23 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Inverse variance weighted",11,{"v":-0.0385476440761542,"d":"-0.0385"},{"v":0.0432084387252578,"d":"0.0432"},{"v":0.372322020752638,"d":"0.3723"},{"v":0.962185861191294,"d":"0.9622"},{"v":0.884054838313139,"d":"0.8841"},{"v":1.04722194976383,"d":"1.0472"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Fibroblast growth factor 23 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Simple mode",11,{"v":0.00432974271481151,"d":"0.0043"},{"v":0.098716864721741,"d":"0.0987"},{"v":0.965879280269841,"d":"0.9659"},{"v":1.0043391295935,"d":"1.0043"},{"v":0.827657951384439,"d":"0.8277"},{"v":1.2187366599274,"d":"1.2187"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Fibroblast growth factor 23 levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted mode",11,{"v":0.012164033204889,"d":"0.0122"},{"v":0.0976396521792239,"d":"0.0976"},{"v":0.903324107009558,"d":"0.9033"},{"v":1.0122383159438,"d":"1.0122"},{"v":0.835930598855606,"d":"0.8359"},{"v":1.22573142993864,"d":"1.2257"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Fibroblast growth factor 23 levels","s_Roseburia_unclassified","MR Egger",14,{"v":0.198759531258172,"d":"0.1988"},{"v":0.102928716477054,"d":"0.1029"},{"v":0.0774413649036719,"d":"0.0774"},{"v":1.21988858555355,"d":"1.2199"},{"v":0.997023684996824,"d":"0.9970"},{"v":1.49257052119938,"d":"1.4926"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Fibroblast growth factor 23 levels","s_Roseburia_unclassified","Weighted median",14,{"v":0.0154722228901674,"d":"0.0155"},{"v":0.0341773530181506,"d":"0.0342"},{"v":0.650761931122769,"d":"0.6508"},{"v":1.01559253744105,"d":"1.0156"},{"v":0.949789033522165,"d":"0.9498"},{"v":1.08595505496735,"d":"1.0860"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Fibroblast growth factor 23 levels","s_Roseburia_unclassified","Inverse variance weighted",14,{"v":0.0440840976481558,"d":"0.0441"},{"v":0.0252166597043791,"d":"0.0252"},{"v":0.0804271147248589,"d":"0.0804"},{"v":1.04507023914223,"d":"1.0451"},{"v":0.994673680040471,"d":"0.9947"},{"v":1.0980202117104,"d":"1.0980"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Fibroblast growth factor 23 levels","s_Roseburia_unclassified","Simple mode",14,{"v":-0.00308069515871273,"d":"-0.0031"},{"v":0.0542937880979616,"d":"0.0543"},{"v":0.955614193381636,"d":"0.9556"},{"v":0.996924045313385,"d":"0.9969"},{"v":0.896285283581194,"d":"0.8963"},{"v":1.1088629595177,"d":"1.1089"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Fibroblast growth factor 23 levels","s_Roseburia_unclassified","Weighted mode",14,{"v":-0.00308069515871273,"d":"-0.0031"},{"v":0.0543188096889614,"d":"0.0543"},{"v":0.955634615802614,"d":"0.9556"},{"v":0.996924045313385,"d":"0.9969"},{"v":0.896241328750807,"d":"0.8962"},{"v":1.10891734206149,"d":"1.1089"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Interleukin-10 receptor subunit alpha levels","g_Roseburia","MR Egger",14,{"v":-0.15924188670451,"d":"-0.1592"},{"v":0.230124505718516,"d":"0.2301"},{"v":0.502119067778477,"d":"0.5021"},{"v":0.852790055442947,"d":"0.8528"},{"v":0.543195537535188,"d":"0.5432"},{"v":1.33883809495632,"d":"1.3388"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Interleukin-10 receptor subunit alpha levels","g_Roseburia","Weighted median",14,{"v":-0.0679384466884389,"d":"-0.0679"},{"v":0.0654802282967256,"d":"0.0655"},{"v":0.299483619397028,"d":"0.2995"},{"v":0.934317982173127,"d":"0.9343"},{"v":0.821782354814427,"d":"0.8218"},{"v":1.0622643412795,"d":"1.0623"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Interleukin-10 receptor subunit alpha levels","g_Roseburia","Inverse variance weighted",14,{"v":-0.0552413766663342,"d":"-0.0552"},{"v":0.0525872627092201,"d":"0.0526"},{"v":0.29350177268519,"d":"0.2935"},{"v":0.946256716093905,"d":"0.9463"},{"v":0.853583071076038,"d":"0.8536"},{"v":1.04899195297309,"d":"1.0490"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Interleukin-10 receptor subunit alpha levels","g_Roseburia","Simple mode",14,{"v":-0.0584074669816727,"d":"-0.0584"},{"v":0.122278912262135,"d":"0.1223"},{"v":0.640825106569165,"d":"0.6408"},{"v":0.943265519567112,"d":"0.9433"},{"v":0.742246311266272,"d":"0.7422"},{"v":1.19872585002989,"d":"1.1987"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Interleukin-10 receptor subunit alpha levels","g_Roseburia","Weighted mode",14,{"v":-0.0584074669816727,"d":"-0.0584"},{"v":0.114028641982786,"d":"0.1140"},{"v":0.617089543846226,"d":"0.6171"},{"v":0.943265519567112,"d":"0.9433"},{"v":0.754346396047262,"d":"0.7543"},{"v":1.17949770167453,"d":"1.1795"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Interleukin-10 receptor subunit alpha levels","g_Faecalibacterium","MR Egger",8,{"v":0.0360546407223986,"d":"0.0361"},{"v":0.37470272035709,"d":"0.3747"},{"v":0.926477707947141,"d":"0.9265"},{"v":1.03671249166281,"d":"1.0367"},{"v":0.497399033271876,"d":"0.4974"},{"v":2.16078584491788,"d":"2.1608"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Interleukin-10 receptor subunit alpha levels","g_Faecalibacterium","Weighted median",8,{"v":-0.0278348480084634,"d":"-0.0278"},{"v":0.0879966060080639,"d":"0.0880"},{"v":0.751761688300279,"d":"0.7518"},{"v":0.972548971938335,"d":"0.9725"},{"v":0.818478462590861,"d":"0.8185"},{"v":1.15562173722233,"d":"1.1556"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Interleukin-10 receptor subunit alpha levels","g_Faecalibacterium","Inverse variance weighted",8,{"v":-0.0961935283094673,"d":"-0.0962"},{"v":0.078489071596277,"d":"0.0785"},{"v":0.220362083273715,"d":"0.2204"},{"v":0.908288219574812,"d":"0.9083"},{"v":0.778775777240308,"d":"0.7788"},{"v":1.0593389187602,"d":"1.0593"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Interleukin-10 receptor subunit alpha levels","g_Faecalibacterium","Simple mode",8,{"v":0.000202011616044495,"d":"0.0002"},{"v":0.157670651774206,"d":"0.1577"},{"v":0.999013478793253,"d":"0.9990"},{"v":1.00020203202177,"d":"1.0002"},{"v":0.734303780673101,"d":"0.7343"},{"v":1.36238452148979,"d":"1.3624"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Interleukin-10 receptor subunit alpha levels","g_Faecalibacterium","Weighted mode",8,{"v":0.00298878219454868,"d":"0.0030"},{"v":0.147598753704873,"d":"0.1476"},{"v":0.984409546781902,"d":"0.9844"},{"v":1.00299325305709,"d":"1.0030"},{"v":0.751033684720812,"d":"0.7510"},{"v":1.33948115263566,"d":"1.3395"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Interleukin-10 receptor subunit alpha levels","s_Odoribacter_splanchnicus","MR Egger",14,{"v":-0.278375191048101,"d":"-0.2784"},{"v":0.169725905969313,"d":"0.1697"},{"v":0.126906711268003,"d":"0.1269"},{"v":0.757012743821184,"d":"0.7570"},{"v":0.542787181534998,"d":"0.5428"},{"v":1.0557881869779,"d":"1.0558"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Interleukin-10 receptor subunit alpha levels","s_Odoribacter_splanchnicus","Weighted median",14,{"v":-0.0816009758047503,"d":"-0.0816"},{"v":0.058154057624362,"d":"0.0582"},{"v":0.160561297681494,"d":"0.1606"},{"v":0.921639641850632,"d":"0.9216"},{"v":0.822355143853461,"d":"0.8224"},{"v":1.03291094581142,"d":"1.0329"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Interleukin-10 receptor subunit alpha levels","s_Odoribacter_splanchnicus","Inverse variance weighted",14,{"v":-0.0766516562664024,"d":"-0.0767"},{"v":0.0465876221998361,"d":"0.0466"},{"v":0.0999033521540273,"d":"0.0999"},{"v":0.926212437716816,"d":"0.9262"},{"v":0.845384778770362,"d":"0.8454"},{"v":1.01476806931528,"d":"1.0148"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Interleukin-10 receptor subunit alpha levels","s_Odoribacter_splanchnicus","Simple mode",14,{"v":-0.133821980221683,"d":"-0.1338"},{"v":0.0927215774132106,"d":"0.0927"},{"v":0.172607440482617,"d":"0.1726"},{"v":0.874745772791911,"d":"0.8747"},{"v":0.729383026079177,"d":"0.7294"},{"v":1.04907865916564,"d":"1.0491"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Interleukin-10 receptor subunit alpha levels","s_Odoribacter_splanchnicus","Weighted mode",14,{"v":-0.112728093467104,"d":"-0.1127"},{"v":0.100156911982696,"d":"0.1002"},{"v":0.280721444974353,"d":"0.2807"},{"v":0.893393546635081,"d":"0.8934"},{"v":0.734154603590108,"d":"0.7342"},{"v":1.08717159201365,"d":"1.0872"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Interleukin-10 receptor subunit alpha levels","s_Paraprevotella_unclassified","MR Egger",9,{"v":-0.0491586911549608,"d":"-0.0492"},{"v":0.353417475240696,"d":"0.3534"},{"v":0.89329210018129,"d":"0.8933"},{"v":0.952030038964,"d":"0.9520"},{"v":0.476228764445232,"d":"0.4762"},{"v":1.90320548181425,"d":"1.9032"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Interleukin-10 receptor subunit alpha levels","s_Paraprevotella_unclassified","Weighted median",9,{"v":-0.0185482329498876,"d":"-0.0185"},{"v":0.0575896727305057,"d":"0.0576"},{"v":0.747395362706132,"d":"0.7474"},{"v":0.981622726890146,"d":"0.9816"},{"v":0.876845920346628,"d":"0.8768"},{"v":1.09891961128853,"d":"1.0989"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Interleukin-10 receptor subunit alpha levels","s_Paraprevotella_unclassified","Inverse variance weighted",9,{"v":-0.0104050605442405,"d":"-0.0104"},{"v":0.0433202106063265,"d":"0.0433"},{"v":0.810183338596444,"d":"0.8102"},{"v":0.989648884834459,"d":"0.9896"},{"v":0.909088642249812,"d":"0.9091"},{"v":1.07734809317412,"d":"1.0773"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Interleukin-10 receptor subunit alpha levels","s_Paraprevotella_unclassified","Simple mode",9,{"v":-0.0447416624319223,"d":"-0.0447"},{"v":0.0941514181882377,"d":"0.0942"},{"v":0.647341196481574,"d":"0.6473"},{"v":0.956244483801215,"d":"0.9562"},{"v":0.795107111401297,"d":"0.7951"},{"v":1.15003815170098,"d":"1.1500"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Interleukin-10 receptor subunit alpha levels","s_Paraprevotella_unclassified","Weighted mode",9,{"v":-0.0378466392126272,"d":"-0.0378"},{"v":0.0954857653447419,"d":"0.0955"},{"v":0.702202457074664,"d":"0.7022"},{"v":0.962860594627686,"d":"0.9629"},{"v":0.798517225458734,"d":"0.7985"},{"v":1.1610275835367,"d":"1.1610"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Interleukin-10 receptor subunit alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","MR Egger",11,{"v":-0.387047346372105,"d":"-0.3870"},{"v":0.256800689629211,"d":"0.2568"},{"v":0.166031048752089,"d":"0.1660"},{"v":0.679058943188104,"d":"0.6791"},{"v":0.410501088665627,"d":"0.4105"},{"v":1.1233126075808,"d":"1.1233"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Interleukin-10 receptor subunit alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted median",11,{"v":-0.0150241067247061,"d":"-0.0150"},{"v":0.0664607842712963,"d":"0.0665"},{"v":0.821154967280804,"d":"0.8212"},{"v":0.985088192066969,"d":"0.9851"},{"v":0.864773856419425,"d":"0.8648"},{"v":1.12214163153322,"d":"1.1221"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Interleukin-10 receptor subunit alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Inverse variance weighted",11,{"v":-0.00261057781421,"d":"-0.0026"},{"v":0.0493112817023922,"d":"0.0493"},{"v":0.957779090610863,"d":"0.9578"},{"v":0.997392826780754,"d":"0.9974"},{"v":0.905506620775591,"d":"0.9055"},{"v":1.09860317759095,"d":"1.0986"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Interleukin-10 receptor subunit alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Simple mode",11,{"v":-0.00975062687021899,"d":"-0.0098"},{"v":0.107235737887825,"d":"0.1072"},{"v":0.929346145858243,"d":"0.9293"},{"v":0.990296756361502,"d":"0.9903"},{"v":0.802572830859888,"d":"0.8026"},{"v":1.22192980867467,"d":"1.2219"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Interleukin-10 receptor subunit alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted mode",11,{"v":-0.0115298614730968,"d":"-0.0115"},{"v":0.104831574190285,"d":"0.1048"},{"v":0.914597491349874,"d":"0.9146"},{"v":0.988536352655466,"d":"0.9885"},{"v":0.804930173044026,"d":"0.8049"},{"v":1.21402346842814,"d":"1.2140"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Leukemia inhibitory factor levels","g_Roseburia","MR Egger",14,{"v":0.116310767381415,"d":"0.1163"},{"v":0.232288469416782,"d":"0.2323"},{"v":0.625627601164988,"d":"0.6256"},{"v":1.12334491685283,"d":"1.1233"},{"v":0.712500523091938,"d":"0.7125"},{"v":1.77109175547405,"d":"1.7711"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Leukemia inhibitory factor levels","g_Roseburia","Weighted median",14,{"v":-0.0667939123472164,"d":"-0.0668"},{"v":0.0657373984096591,"d":"0.0657"},{"v":0.309595228447269,"d":"0.3096"},{"v":0.935387953381941,"d":"0.9354"},{"v":0.822308859323021,"d":"0.8223"},{"v":1.06401702159986,"d":"1.0640"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Leukemia inhibitory factor levels","g_Roseburia","Inverse variance weighted",14,{"v":-0.00175579127517946,"d":"-0.0018"},{"v":0.0531909018197944,"d":"0.0532"},{"v":0.973667218735876,"d":"0.9737"},{"v":0.998245749224591,"d":"0.9982"},{"v":0.899415690892586,"d":"0.8994"},{"v":1.10793550294418,"d":"1.1079"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Leukemia inhibitory factor levels","g_Roseburia","Simple mode",14,{"v":-0.117693521629221,"d":"-0.1177"},{"v":0.116640461559068,"d":"0.1166"},{"v":0.331373886729266,"d":"0.3314"},{"v":0.888968460474367,"d":"0.8890"},{"v":0.707294022389082,"d":"0.7073"},{"v":1.11730751102466,"d":"1.1173"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Leukemia inhibitory factor levels","g_Roseburia","Weighted mode",14,{"v":-0.11315486795216,"d":"-0.1132"},{"v":0.111288466157636,"d":"0.1113"},{"v":0.327813009944179,"d":"0.3278"},{"v":0.89301235041246,"d":"0.8930"},{"v":0.718003911899237,"d":"0.7180"},{"v":1.11067787343908,"d":"1.1107"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Leukemia inhibitory factor levels","g_Faecalibacterium","MR Egger",8,{"v":-0.364392089566794,"d":"-0.3644"},{"v":0.419500399238452,"d":"0.4195"},{"v":0.418432696057415,"d":"0.4184"},{"v":0.694618788562696,"d":"0.6946"},{"v":0.305253447487682,"d":"0.3053"},{"v":1.58063820538432,"d":"1.5806"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Leukemia inhibitory factor levels","g_Faecalibacterium","Weighted median",8,{"v":0.0639695516152214,"d":"0.0640"},{"v":0.0918520791176112,"d":"0.0919"},{"v":0.486152709269099,"d":"0.4862"},{"v":1.06605993846412,"d":"1.0661"},{"v":0.890421330291015,"d":"0.8904"},{"v":1.276343854012,"d":"1.2763"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Leukemia inhibitory factor levels","g_Faecalibacterium","Inverse variance weighted",8,{"v":0.00427373371323088,"d":"0.0043"},{"v":0.0925939905719231,"d":"0.0926"},{"v":0.963186209090904,"d":"0.9632"},{"v":1.00428287913688,"d":"1.0043"},{"v":0.837603460650446,"d":"0.8376"},{"v":1.20413077155179,"d":"1.2041"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Leukemia inhibitory factor levels","g_Faecalibacterium","Simple mode",8,{"v":0.163983952194887,"d":"0.1640"},{"v":0.150642482797167,"d":"0.1506"},{"v":0.31239835489946,"d":"0.3124"},{"v":1.17819540749073,"d":"1.1782"},{"v":0.876976297222453,"d":"0.8770"},{"v":1.58287564057176,"d":"1.5829"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Leukemia inhibitory factor levels","g_Faecalibacterium","Weighted mode",8,{"v":0.15449926977936,"d":"0.1545"},{"v":0.149374140333604,"d":"0.1494"},{"v":0.335395401547414,"d":"0.3354"},{"v":1.16707342583608,"d":"1.1671"},{"v":0.87086000397282,"d":"0.8709"},{"v":1.56404057492491,"d":"1.5640"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Leukemia inhibitory factor levels","s_Odoribacter_splanchnicus","MR Egger",14,{"v":0.1540978517331,"d":"0.1541"},{"v":0.176343644425761,"d":"0.1763"},{"v":0.399350501437789,"d":"0.3994"},{"v":1.16660503551809,"d":"1.1666"},{"v":0.825690154591374,"d":"0.8257"},{"v":1.64827847507725,"d":"1.6483"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Leukemia inhibitory factor levels","s_Odoribacter_splanchnicus","Weighted median",14,{"v":-0.00952588838759233,"d":"-0.0095"},{"v":0.0633811945898121,"d":"0.0634"},{"v":0.880531731392301,"d":"0.8805"},{"v":0.9905193391624,"d":"0.9905"},{"v":0.874806088975524,"d":"0.8748"},{"v":1.12153833131604,"d":"1.1215"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Leukemia inhibitory factor levels","s_Odoribacter_splanchnicus","Inverse variance weighted",14,{"v":0.00868448637197915,"d":"0.0087"},{"v":0.0468293076954222,"d":"0.0468"},{"v":0.852876240538076,"d":"0.8529"},{"v":1.00872230592561,"d":"1.0087"},{"v":0.920258236285362,"d":"0.9203"},{"v":1.10569039249147,"d":"1.1057"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Leukemia inhibitory factor levels","s_Odoribacter_splanchnicus","Simple mode",14,{"v":-0.121592048125618,"d":"-0.1216"},{"v":0.124419259244411,"d":"0.1244"},{"v":0.346268716802745,"d":"0.3463"},{"v":0.885509540103971,"d":"0.8855"},{"v":0.693881698512257,"d":"0.6939"},{"v":1.13005883754591,"d":"1.1301"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Leukemia inhibitory factor levels","s_Odoribacter_splanchnicus","Weighted mode",14,{"v":-0.108821262788035,"d":"-0.1088"},{"v":0.118208144500206,"d":"0.1182"},{"v":0.374032223429938,"d":"0.3740"},{"v":0.896890710917716,"d":"0.8969"},{"v":0.711407963071544,"d":"0.7114"},{"v":1.13073368458991,"d":"1.1307"},{"v":0.002832495,"d":"0.0028"},{"v":21.9753107668269,"d":"21.9753"}]
["Leukemia inhibitory factor levels","s_Paraprevotella_unclassified","MR Egger",9,{"v":-0.286274118731483,"d":"-0.2863"},{"v":0.447818131982273,"d":"0.4478"},{"v":0.542995930213144,"d":"0.5430"},{"v":0.751056709014355,"d":"0.7511"},{"v":0.312235472144744,"d":"0.3122"},{"v":1.8066050480452,"d":"1.8066"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Leukemia inhibitory factor levels","s_Paraprevotella_unclassified","Weighted median",9,{"v":0.00253243234491671,"d":"0.0025"},{"v":0.0581323449564055,"d":"0.0581"},{"v":0.965252567123696,"d":"0.9653"},{"v":1.00253564166026,"d":"1.0025"},{"v":0.894574615381778,"d":"0.8946"},{"v":1.12352585856711,"d":"1.1235"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Leukemia inhibitory factor levels","s_Paraprevotella_unclassified","Inverse variance weighted",9,{"v":0.0430124515850791,"d":"0.0430"},{"v":0.0533397999951072,"d":"0.0533"},{"v":0.420020493704388,"d":"0.4200"},{"v":1.04395089361306,"d":"1.0440"},{"v":0.940321391404255,"d":"0.9403"},{"v":1.15900103755798,"d":"1.1590"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Leukemia inhibitory factor levels","s_Paraprevotella_unclassified","Simple mode",9,{"v":-0.00615273610950984,"d":"-0.0062"},{"v":0.0807847997121511,"d":"0.0808"},{"v":0.94116040653487,"d":"0.9412"},{"v":0.993866153211117,"d":"0.9939"},{"v":0.848325439730444,"d":"0.8483"},{"v":1.16437617479977,"d":"1.1644"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Leukemia inhibitory factor levels","s_Paraprevotella_unclassified","Weighted mode",9,{"v":-0.018183694875488,"d":"-0.0182"},{"v":0.0781208241219761,"d":"0.0781"},{"v":0.821789492466466,"d":"0.8218"},{"v":0.981980630979664,"d":"0.9820"},{"v":0.842568335082568,"d":"0.8426"},{"v":1.14446024075273,"d":"1.1445"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Leukemia inhibitory factor levels","s_Lachnospiraceae_bacterium_7_1_58FAA","MR Egger",11,{"v":0.201996965476004,"d":"0.2020"},{"v":0.256081259760061,"d":"0.2561"},{"v":0.450506661079797,"d":"0.4505"},{"v":1.22384429432084,"d":"1.2238"},{"v":0.740875781786841,"d":"0.7409"},{"v":2.02165449804461,"d":"2.0217"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Leukemia inhibitory factor levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted median",11,{"v":0.00243635951972521,"d":"0.0024"},{"v":0.0666208091267078,"d":"0.0666"},{"v":0.970827426845897,"d":"0.9708"},{"v":1.00243932985536,"d":"1.0024"},{"v":0.879729833204448,"d":"0.8797"},{"v":1.14226501377194,"d":"1.1423"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Leukemia inhibitory factor levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Inverse variance weighted",11,{"v":-0.0362599512022898,"d":"-0.0363"},{"v":0.0492256261483019,"d":"0.0492"},{"v":0.461361248311214,"d":"0.4614"},{"v":0.964389566668835,"d":"0.9644"},{"v":0.875690834972633,"d":"0.8757"},{"v":1.06207259360979,"d":"1.0621"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Leukemia inhibitory factor levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Simple mode",11,{"v":0.0394147692026449,"d":"0.0394"},{"v":0.110616542831073,"d":"0.1106"},{"v":0.729004819757771,"d":"0.7290"},{"v":1.04020183787463,"d":"1.0402"},{"v":0.837450053438858,"d":"0.8375"},{"v":1.29204107047892,"d":"1.2920"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Leukemia inhibitory factor levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted mode",11,{"v":0.0473215981554933,"d":"0.0473"},{"v":0.103033429998904,"d":"0.1030"},{"v":0.655852146755877,"d":"0.6559"},{"v":1.04845913739152,"d":"1.0485"},{"v":0.856737314697912,"d":"0.8567"},{"v":1.28308472611279,"d":"1.2831"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Leukemia inhibitory factor levels","s_Roseburia_unclassified","MR Egger",14,{"v":-0.0289459491414576,"d":"-0.0289"},{"v":0.116488561550156,"d":"0.1165"},{"v":0.807958851316325,"d":"0.8080"},{"v":0.971468971779531,"d":"0.9715"},{"v":0.773164435062458,"d":"0.7732"},{"v":1.22063550822037,"d":"1.2206"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Leukemia inhibitory factor levels","s_Roseburia_unclassified","Weighted median",14,{"v":-0.0478639500083429,"d":"-0.0479"},{"v":0.0361256971604166,"d":"0.0361"},{"v":0.185195011642422,"d":"0.1852"},{"v":0.953263469742747,"d":"0.9533"},{"v":0.888100544649623,"d":"0.8881"},{"v":1.02320761789927,"d":"1.0232"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Leukemia inhibitory factor levels","s_Roseburia_unclassified","Inverse variance weighted",14,{"v":-0.0435809555393729,"d":"-0.0436"},{"v":0.0285300828907332,"d":"0.0285"},{"v":0.126625806949809,"d":"0.1266"},{"v":0.957355047759463,"d":"0.9574"},{"v":0.90529002409757,"d":"0.9053"},{"v":1.01241443413027,"d":"1.0124"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Leukemia inhibitory factor levels","s_Roseburia_unclassified","Simple mode",14,{"v":-0.0538805352623695,"d":"-0.0539"},{"v":0.0590068088916905,"d":"0.0590"},{"v":0.377801074084543,"d":"0.3778"},{"v":0.947545297990885,"d":"0.9475"},{"v":0.844058156723089,"d":"0.8441"},{"v":1.0637206507551,"d":"1.0637"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Leukemia inhibitory factor levels","s_Roseburia_unclassified","Weighted mode",14,{"v":-0.0516966118019216,"d":"-0.0517"},{"v":0.0602168826698898,"d":"0.0602"},{"v":0.406163876467159,"d":"0.4062"},{"v":0.949616925711806,"d":"0.9496"},{"v":0.843899639640693,"d":"0.8439"},{"v":1.06857766402447,"d":"1.0686"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Transforming growth factor-alpha levels","g_Roseburia","MR Egger",14,{"v":-0.139086197551568,"d":"-0.1391"},{"v":0.174636279404708,"d":"0.1746"},{"v":0.441252333620137,"d":"0.4413"},{"v":0.870153020165705,"d":"0.8702"},{"v":0.617934196601459,"d":"0.6179"},{"v":1.22531862238373,"d":"1.2253"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Transforming growth factor-alpha levels","g_Roseburia","Weighted median",14,{"v":0.0173363933328382,"d":"0.0173"},{"v":0.0538178371362761,"d":"0.0538"},{"v":0.747353459435526,"d":"0.7474"},{"v":1.01748754078698,"d":"1.0175"},{"v":0.915626665818626,"d":"0.9156"},{"v":1.13068014978695,"d":"1.1307"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Transforming growth factor-alpha levels","g_Roseburia","Inverse variance weighted",14,{"v":0.0122308373165629,"d":"0.0122"},{"v":0.0408581764696136,"d":"0.0409"},{"v":0.764674087541499,"d":"0.7647"},{"v":1.01230593988406,"d":"1.0123"},{"v":0.934399512565036,"d":"0.9344"},{"v":1.09670788794768,"d":"1.0967"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Transforming growth factor-alpha levels","g_Roseburia","Simple mode",14,{"v":-0.000150755339429209,"d":"-0.0002"},{"v":0.0874317066264833,"d":"0.0874"},{"v":0.998650415943627,"d":"0.9987"},{"v":0.999849256023586,"d":"0.9998"},{"v":0.842386031300049,"d":"0.8424"},{"v":1.1867463343713,"d":"1.1867"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Transforming growth factor-alpha levels","g_Roseburia","Weighted mode",14,{"v":0.00870412286213335,"d":"0.0087"},{"v":0.0878489693711491,"d":"0.0878"},{"v":0.922585868970221,"d":"0.9226"},{"v":1.00874211388571,"d":"1.0087"},{"v":0.84918360384521,"d":"0.8492"},{"v":1.19828108752804,"d":"1.1983"},{"v":0.002799654,"d":"0.0028"},{"v":21.7194807841711,"d":"21.7195"}]
["Transforming growth factor-alpha levels","g_Faecalibacterium","MR Egger",8,{"v":0.172213006869049,"d":"0.1722"},{"v":0.246372881629794,"d":"0.2464"},{"v":0.510729033894104,"d":"0.5107"},{"v":1.18793084369613,"d":"1.1879"},{"v":0.732949964173955,"d":"0.7329"},{"v":1.92534246317211,"d":"1.9253"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Transforming growth factor-alpha levels","g_Faecalibacterium","Weighted median",8,{"v":0.0646403239878655,"d":"0.0646"},{"v":0.0687961978605431,"d":"0.0688"},{"v":0.347427128662105,"d":"0.3474"},{"v":1.06677526190121,"d":"1.0668"},{"v":0.932207151143092,"d":"0.9322"},{"v":1.22076885809011,"d":"1.2208"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Transforming growth factor-alpha levels","g_Faecalibacterium","Inverse variance weighted",8,{"v":0.00940112189479852,"d":"0.0094"},{"v":0.0550062862333478,"d":"0.0550"},{"v":0.864294569023427,"d":"0.8643"},{"v":1.00944545124756,"d":"1.0094"},{"v":0.906276167159957,"d":"0.9063"},{"v":1.12435939062329,"d":"1.1244"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Transforming growth factor-alpha levels","g_Faecalibacterium","Simple mode",8,{"v":0.0743424778910358,"d":"0.0743"},{"v":0.105021464742708,"d":"0.1050"},{"v":0.50190301325949,"d":"0.5019"},{"v":1.07717565117716,"d":"1.0772"},{"v":0.876779631982939,"d":"0.8768"},{"v":1.32337401687214,"d":"1.3234"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Transforming growth factor-alpha levels","g_Faecalibacterium","Weighted mode",8,{"v":0.0743424778910358,"d":"0.0743"},{"v":0.0970815552222832,"d":"0.0971"},{"v":0.468840440212111,"d":"0.4688"},{"v":1.07717565117716,"d":"1.0772"},{"v":0.890530995200284,"d":"0.8905"},{"v":1.30293879690058,"d":"1.3029"},{"v":0.002771333,"d":"0.0028"},{"v":21.4988379688505,"d":"21.4988"}]
["Transforming growth factor-alpha levels","s_Paraprevotella_unclassified","MR Egger",9,{"v":-0.0445241555549466,"d":"-0.0445"},{"v":0.317539764276067,"d":"0.3175"},{"v":0.892438691015915,"d":"0.8924"},{"v":0.956452496173753,"d":"0.9565"},{"v":0.51329626107474,"d":"0.5133"},{"v":1.78220931421084,"d":"1.7822"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Transforming growth factor-alpha levels","s_Paraprevotella_unclassified","Weighted median",9,{"v":0.0380609617957525,"d":"0.0381"},{"v":0.0509520540930322,"d":"0.0510"},{"v":0.455066198119663,"d":"0.4551"},{"v":1.03879455772994,"d":"1.0388"},{"v":0.940066121447454,"d":"0.9401"},{"v":1.14789173713421,"d":"1.1479"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Transforming growth factor-alpha levels","s_Paraprevotella_unclassified","Inverse variance weighted",9,{"v":0.00372075026065028,"d":"0.0037"},{"v":0.038460133339763,"d":"0.0385"},{"v":0.92293045825728,"d":"0.9229"},{"v":1.00372768084489,"d":"1.0037"},{"v":0.930846295856367,"d":"0.9308"},{"v":1.08231537449199,"d":"1.0823"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Transforming growth factor-alpha levels","s_Paraprevotella_unclassified","Simple mode",9,{"v":0.0425088254069919,"d":"0.0425"},{"v":0.0715499407286035,"d":"0.0715"},{"v":0.568851330392662,"d":"0.5689"},{"v":1.04342526498567,"d":"1.0434"},{"v":0.906894585920692,"d":"0.9069"},{"v":1.20051029139745,"d":"1.2005"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Transforming growth factor-alpha levels","s_Paraprevotella_unclassified","Weighted mode",9,{"v":0.0425088254069919,"d":"0.0425"},{"v":0.0730001290139312,"d":"0.0730"},{"v":0.576395748205384,"d":"0.5764"},{"v":1.04342526498567,"d":"1.0434"},{"v":0.904320516788024,"d":"0.9043"},{"v":1.20392743877736,"d":"1.2039"},{"v":0.002734651,"d":"0.0027"},{"v":21.2136241967536,"d":"21.2136"}]
["Transforming growth factor-alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","MR Egger",11,{"v":-0.159944761531819,"d":"-0.1599"},{"v":0.231381986630198,"d":"0.2314"},{"v":0.506840170854113,"d":"0.5068"},{"v":0.852190861383876,"d":"0.8522"},{"v":0.541477667491958,"d":"0.5415"},{"v":1.34119892255202,"d":"1.3412"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Transforming growth factor-alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted median",11,{"v":-0.0262745905312705,"d":"-0.0263"},{"v":0.0605240764900608,"d":"0.0605"},{"v":0.664202761110482,"d":"0.6642"},{"v":0.97406758314791,"d":"0.9741"},{"v":0.865107259382168,"d":"0.8651"},{"v":1.09675146780899,"d":"1.0968"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Transforming growth factor-alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Inverse variance weighted",11,{"v":0.00979388239543379,"d":"0.0098"},{"v":0.0441725844831026,"d":"0.0442"},{"v":0.82453297081374,"d":"0.8245"},{"v":1.00984199941748,"d":"1.0098"},{"v":0.92608951254594,"d":"0.9261"},{"v":1.10116878549244,"d":"1.1012"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Transforming growth factor-alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Simple mode",11,{"v":-0.0381268702033493,"d":"-0.0381"},{"v":0.0894273836492101,"d":"0.0894"},{"v":0.678888690922724,"d":"0.6789"},{"v":0.962590809052231,"d":"0.9626"},{"v":0.807829270110734,"d":"0.8078"},{"v":1.14700110525188,"d":"1.1470"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Transforming growth factor-alpha levels","s_Lachnospiraceae_bacterium_7_1_58FAA","Weighted mode",11,{"v":-0.041208367832089,"d":"-0.0412"},{"v":0.0964560428638053,"d":"0.0965"},{"v":0.678268682814342,"d":"0.6783"},{"v":0.959629153267893,"d":"0.9596"},{"v":0.794325293693102,"d":"0.7943"},{"v":1.1593337378445,"d":"1.1593"},{"v":0.003023114,"d":"0.0030"},{"v":23.458750801318,"d":"23.4588"}]
["Transforming growth factor-alpha levels","s_Roseburia_unclassified","MR Egger",14,{"v":0.245268705786724,"d":"0.2453"},{"v":0.15707833524845,"d":"0.1571"},{"v":0.144393004810039,"d":"0.1444"},{"v":1.27796466357304,"d":"1.2780"},{"v":0.939314588082348,"d":"0.9393"},{"v":1.73870788558238,"d":"1.7387"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Transforming growth factor-alpha levels","s_Roseburia_unclassified","Weighted median",14,{"v":-0.0172918750844791,"d":"-0.0173"},{"v":0.040222665316352,"d":"0.0402"},{"v":0.667265649731177,"d":"0.6673"},{"v":0.982856771362356,"d":"0.9829"},{"v":0.908347468425587,"d":"0.9083"},{"v":1.06347787228074,"d":"1.0635"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Transforming growth factor-alpha levels","s_Roseburia_unclassified","Inverse variance weighted",14,{"v":0.0108551227712329,"d":"0.0109"},{"v":0.0405648878273995,"d":"0.0406"},{"v":0.789008013052091,"d":"0.7890"},{"v":1.01091425337941,"d":"1.0109"},{"v":0.933651480720197,"d":"0.9337"},{"v":1.09457077805665,"d":"1.0946"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Transforming growth factor-alpha levels","s_Roseburia_unclassified","Simple mode",14,{"v":-0.0841308212506118,"d":"-0.0841"},{"v":0.0866128548364599,"d":"0.0866"},{"v":0.349104282684882,"d":"0.3491"},{"v":0.919310982815673,"d":"0.9193"},{"v":0.775775568306312,"d":"0.7758"},{"v":1.08940358223787,"d":"1.0894"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]
["Transforming growth factor-alpha levels","s_Roseburia_unclassified","Weighted mode",14,{"v":-0.0695971917909102,"d":"-0.0696"},{"v":0.0796435306766151,"d":"0.0796"},{"v":0.398050938787717,"d":"0.3981"},{"v":0.932769471443393,"d":"0.9328"},{"v":0.797958640424822,"d":"0.7980"},{"v":1.09035586906306,"d":"1.0904"},{"v":0.002716433,"d":"0.0027"},{"v":21.0720262637775,"d":"21.0720"}]