{"text_format":"3","workbook":"xls","n_sheets":7,"sheets":["index","eTable 1","eTable 2","eTable 3","eTable 4","eTable 5","eTable 6"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"index","index":0,"n_rows":7,"n_cols":2,"rows_kept":7,"merged":[[0,0,0,12],[1,1,1,12],[2,1,2,12],[3,1,3,12],[4,1,4,12],[5,1,5,12],[6,1,6,12]],"flags":["formulas_cached_only"]}
["Supplementary tables of contents"]
["eTable 1","Associations between modifiable lifestyle factors and breast diseases in heterogeneity analysis and pleiotropy analysis."]
["eTable 2"," The complementary MR analyses results of the causal effects of  modifiable lifestyle factors in overall BC."]
["eTable 3"," The complementary MR analyses results of the causal effects of modifiable lifestyle factors  in ER+ BC."]
["eTable 4"," The complementary MR analyses results of the causal effects of modifiable lifestyle factors  in  ER- BC."]
["eTable 5"," The complementary MR analyses results of the causal effects of modifiable lifestyle factors  in benign neoplasm of breast."]
["eTable 6"," The complementary MR analyses results of the causal effects of modifiable lifestyle factors  in inflammatory disorders of breast."]

{"sheet":"eTable 1","index":1,"n_rows":52,"n_cols":9,"rows_kept":52,"merged":[[0,0,0,8],[1,0,2,0],[1,1,2,1],[1,2,1,5],[1,6,1,8],[4,0,5,0],[4,1,5,1],[6,0,7,0],[6,1,7,1],[8,0,9,0],[8,1,9,1],[10,0,11,0],[10,1,11,1],[13,0,14,0],[13,1,14,1],[15,0,16,0],[15,1,16,1],[17,0,18,0],[17,1,18,1],[19,0,20,0],[19,1,20,1],[21,0,22,0],[21,1,22,1],[24,0,25,0],[24,1,25,1],[26,0,27,0],[26,1,27,1],[28,0,29,0],[28,1,29,1],[30,0,31,0],[30,1,31,1],[33,0,34,0],[33,1,34,1],[35,0,36,0],[35,1,36,1],[37,0,38,0],[37,1,38,1],[39,0,40,0],[39,1,40,1],[41,0,42,0],[41,1,42,1],[44,0,45,0],[44,1,45,1],[46,0,47,0],[46,1,47,1],[48,0,49,0],[48,1,49,1],[50,0,51,0],[50,1,51,1]],"flags":["formulas_cached_only"]}
["Associations between modifiable lifestyle factors and breast diseases in heterogeneity analysis and pleiotropy analysis."]
["risk factor","SNP","Heterogeneity analysis",{"$nulls":3},"Pleiotropy analysis"]
[null,null,"Method","Q","DF","P","Egger intercept","SE","P"]
["(overall BC)"]
["Sleep duration",66,"MR Egger",223.0284,64,{"v":1.826671e-19,"d":"1.83E-19"},-3.970412e-05,0.006189155,0.9949015]
[null,null,"Inverse variance weighted",223.0286,65,3.444077e-19]
["Years of schooling",291,"MR Egger",620.0818,289,2.9684e-26,0.00271687,0.002478365,0.2738887]
[null,null,"Inverse variance weighted",622.6602,290,2.177925e-26]
["Fresh fruit intake",53,"MR Egger",133.9585,51,2.236668e-09,0.00532168,0.005347399,0.3243422]
[null,null,"Inverse variance weighted",136.5599,52,1.6058e-09]
["Body mass index",466,"MR Egger",1210.121,464,5.968599e-68,0.0052545,0.001398169,0.0001930145]
[null,null,"Inverse variance weighted",1246.955,465,9.843644e-73]
["(ER+ BC)"]
["Sleep duration",66,"MR Egger",182.5503,64,2.467793e-13,-0.000706993,0.006700063,0.916293]
[null,null,"Inverse variance weighted",182.582,65,4.174031e-13]
["Fresh fruit intake",53,"MR Egger",120.8467,51,1.339043e-07,0.00894378,0.006054889,0.1457932]
[null,null,"Inverse variance weighted",126.0168,52,4.392852e-08]
["Body mass index",466,"MR Egger",1039.329,464,4.419642e-46,0.004045198,0.001544843,0.009120159]
[null,null,"Inverse variance weighted",1054.687,465,9.042346e-48]
["Sleeplessness/insomnia",36,"MR Egger",63.25244,34,0.0016922909,0.01184516,0.006416989,0.07362804]
[null,null,"Inverse variance weighted",69.59139,35,0.0004491024]
["household income",45,"MR Egger",141.38,43,2.052605e-12,-0.006246923,0.00970424,0.5231685]
[null,null,"Inverse variance weighted",142.7425,44,2.330482e-12]
["(ER- BC)"]
["Years of schooling",291,"MR Egger",414.2931,289,1.807735e-06,0.005553637,0.003690993,0.1335073]
[null,null,"Inverse variance weighted",417.5386,290,1.303653e-06]
["Processed meat intake",23,"MR Egger",33.13154,21,0.04477878,0.01890022,0.01801465,0.3060303]
[null,null,"Inverse variance weighted",34.86815,22,0.0399914]
["Fresh fruit intake",53,"MR Egger",125.541,51,3.183046e-08,0.004257813,0.009420359,0.6531999]
[null,null,"Inverse variance weighted",126.0439,52,4.356491e-08]
["Body mass index",467,"MR Egger",765.5506,465,4.757176e-17,0.008215857,0.002020321,5.602108e-05]
[null,null,"Inverse variance weighted",792.7767,466,2.368785e-19]
["(Breast benign tumors)"]
["physical activity",19,"MR Egger",9.700968,17,0.9156795,-0.02615763,0.03518929,0.4674251]
[null,null,"Inverse variance weighted",10.253523,18,0.9233162]
["Years of schooling",305,"MR Egger",306.1222,303,0.439017,0.01301449,0.008316834,0.1186648]
[null,null,"Inverse variance weighted",308.5962,304,0.4158677]
["Processed meat intake",23,"MR Egger",26.18953,21,0.1993142,-0.02189772,0.04348984,0.6198442]
[null,null,"Inverse variance weighted",26.50571,22,0.2306037]
["pack years of smoking",10,"MR Egger",6.706854,8,0.56856569,-0.0786239,0.02779187,0.02218348]
[null,null,"Inverse variance weighted",14.710236,9,0.09920904]
["household income",45,"MR Egger",42.16283,43,0.507493,0.07076111,0.02817332,0.01585291]
[null,null,"Inverse variance weighted",48.47114,44,0.2973848]
["(Breast inflammatory diseases)"]
["pack years of smoking",10,"MR Egger",13.19695,8,0.1052504,0.03490056,0.05771466,0.5621273]
[null,null,"Inverse variance weighted",13.80017,9,0.1296132]
["Years of schooling",305,"MR Egger",287.3951,303,0.7316875,0.005528887,0.01339253,0.6800204]
[null,null,"Inverse variance weighted",287.5655,304,0.7427175]
["Body mass index",481,"MR Egger",483.7648,479,0.4305555,0.006937613,0.007102934,0.3291984]
[null,null,"Inverse variance weighted",484.7283,480,0.4310867]
["Fresh fruit intake",53,"MR Egger",49.766,51,0.5227194,-0.05214618,0.0272624,0.06140311]
[null,null,"Inverse variance weighted",53.42461,52,0.4192849]

{"sheet":"eTable 2","index":2,"n_rows":74,"n_cols":7,"rows_kept":74,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
[" The complementary MR analyses results of the causal effects of  modifiable lifestyle factors in overall BC."]
["Exposure","Method","or","or_lci95","or_uci95","Estimate","P "]
["Pack years of smoking"]
[null,"MR Egger",1.325194143,0.948995382,1.85052483,"1.33(0.95-1.85)",0.136992008]
[null,"Weighted median",1.041941204,0.884684455,1.227151067,"1.04(0.88-1.23)",0.622582773]
[null,"Inverse variance weighted",0.998491455,0.849120461,1.174138689,"1(0.85-1.17)",0.9854312]
[null,"Simple mode",0.803974116306036,0.514351661103276,1.25667792790561,"0.8(0.51-1.26)",0.363357330507542]
[null,"Weighted mode",1.09542719712084,0.924579961818901,1.29784420357906,"1.1(0.92-1.3)",0.319543340528241]
["Alcoholic drinks per week"]
[null,"MR Egger",0.982872453,0.726620565,1.329494795,"0.98(0.73-1.33)",0.911495512]
[null,"Weighted median",0.953164618,0.808856432,1.123218847,"0.95(0.81-1.12)",0.566853505]
[null,"Inverse variance weighted",1.078383618,0.882254918,1.318112491,"1.08(0.88-1.32)",0.461230013]
[null,"Simple mode",1.35167449642134,0.800790742045957,2.28152480835128,"1.35(0.8-2.28)",0.267873997491151]
[null,"Weighted mode",0.924755582360585,0.775168057780106,1.10320965695629,"0.92(0.78-1.1)",0.391562666280474]
["Physical activity"]
[null,"MR Egger",1.870701934,0.653747441,5.35302397,"1.87(0.65-5.35)",0.25907629]
[null,"Weighted median",0.898761009,0.65643795,1.230537254,"0.9(0.66-1.23)",0.505498886]
[null,"Inverse variance weighted",0.907234885,0.703820522,1.169438957,"0.91(0.7-1.17)",0.452294195]
[null,"Simple mode",0.86922968596459,0.473696525791556,1.59503016345654,"0.87(0.47-1.6)",0.656310365784624]
[null,"Weighted mode",0.897059283988689,0.481323373693414,1.67188090787146,"0.9(0.48-1.67)",0.736313824884323]
["Sleep duration"]
[null,"MR Egger",1.332206271,0.476963027,3.720987684,"1.33(0.48-3.72)",0.586050444]
[null,"Weighted median",1.320339418,1.034913145,1.684485491,"1.32(1.03-1.68)",0.025341924]
[null,"Inverse variance weighted",1.327895704,1.012714436,1.741169018,"1.33(1.01-1.74)",0.040228963]
[null,"Simple mode",1.34400869621352,0.799235110947123,2.26011013624883,"1.34(0.8-2.26)",0.268990133861815]
[null,"Weighted mode",1.34400869621352,0.912863625804211,1.97878338498392,"1.34(0.91-1.98)",0.138959002409892]
["Sleeplessness/insomnia"]
[null,"MR Egger",0.43201024,0.173925005,1.073065069,"0.43(0.17-1.07)",0.079446531]
[null,"Weighted median",0.870364,0.632231485,1.198190077,"0.87(0.63-1.2)",0.394584137]
[null,"Inverse variance weighted",1.060191981,0.795668049,1.412658253,"1.06(0.8-1.41)",0.689791162]
[null,"Simple mode",0.774174871516365,0.363948219638923,1.6467912173935,"0.77(0.36-1.65)",0.510623382546058]
[null,"Weighted mode",0.745599599788538,0.397484958144567,1.39859069334301,"0.75(0.4-1.4)",0.366595620715946]
["Years of schooling"]
[null,"MR Egger",0.750037644,0.524376902,1.072809394,"0.75(0.52-1.07)",0.116320808]
[null,"Weighted median",0.868084635,0.781882755,0.963790197,"0.87(0.78-0.96)",0.008020797]
[null,"Inverse variance weighted",0.910335797,0.831618533,0.996504083,"0.91(0.83-1)",0.04176081]
[null,"Simple mode",0.862535763373296,0.608151376029306,1.22332690909196,"0.86(0.61-1.22)",0.407550505069577]
[null,"Weighted mode",0.862535763373296,0.604962085827256,1.2297761471789,"0.86(0.6-1.23)",0.414529216871707]
["household income"]
[null,"MR Egger",1.571175349,0.635957405,3.881693897,"1.57(0.64-3.88)",0.332990947]
[null,"Weighted median",1.153103706,0.958790964,1.386796712,"1.15(0.96-1.39)",0.13026866]
[null,"Inverse variance weighted",1.065429254,0.856352866,1.325551114,"1.07(0.86-1.33)",0.569598226]
[null,"Simple mode",1.24937211417812,0.827036863310996,1.88737739384048,"1.25(0.83-1.89)",0.295936926262004]
[null,"Weighted mode",1.23652305967552,0.889455360414568,1.71901744051176,"1.24(0.89-1.72)",0.213219536326231]
["Coffee intake"]
[null,"MR Egger",0.995097153,0.485340521,2.040254835,"1(0.49-2.04)",0.989373583]
[null,"Weighted median",0.918778314,0.70152072,1.203319541,"0.92(0.7-1.2)",0.538288361]
[null,"Inverse variance weighted",0.771548792,0.539273003,1.103870461,"0.77(0.54-1.1)",0.155832301]
[null,"Simple mode",0.747106560809747,0.413776755256961,1.34895981012355,"0.75(0.41-1.35)",0.34013644356513]
[null,"Weighted mode",1.07068917383107,0.83899092751795,1.36637390150389,"1.07(0.84-1.37)",0.58650517305]
["Processed meat intake"]
[null,"MR Egger",0.413072821,0.082061001,2.079296529,"0.41(0.08-2.08)",0.295784445]
[null,"Weighted median",1.273124414,0.911827171,1.777580034,"1.27(0.91-1.78)",0.156198891]
[null,"Inverse variance weighted",1.284510596,0.926831947,1.780222916,"1.28(0.93-1.78)",0.132665164]
[null,"Simple mode",1.77598497397228,0.850199685732277,3.70986096643715,"1.78(0.85-3.71)",0.140712758221568]
[null,"Weighted mode",1.65610708870154,0.837573943174097,3.27456544177305,"1.66(0.84-3.27)",0.161055642195209]
["Tea intake"]
[null,"MR Egger",1.025889501,0.558870882,1.883170695,"1.03(0.56-1.88)",0.934710155]
[null,"Weighted median",1.185037796,0.970128215,1.447555648,"1.19(0.97-1.45)",0.096323223]
[null,"Inverse variance weighted",1.257362265,0.963561179,1.640746742,"1.26(0.96-1.64)",0.091674803]
[null,"Simple mode",1.26149970295649,0.864511392555842,1.84078719408722,"1.26(0.86-1.84)",0.235704182732598]
[null,"Weighted mode",1.20900128782771,0.964593015970757,1.51533764993938,"1.21(0.96-1.52)",0.10777421267177]
["Fresh fruit intake"]
[null,"MR Egger",0.370394476,0.118432765,1.158396227,"0.37(0.12-1.16)",0.093857609]
[null,"Weighted median",0.661353366,0.458578122,0.953792285,"0.66(0.46-0.95)",0.026880992]
[null,"Inverse variance weighted",0.644309981,0.461547411,0.89944249,"0.64(0.46-0.9)",0.009803784]
[null,"Simple mode",0.724611353330463,0.354122219697558,1.48271298486675,"0.72(0.35-1.48)",0.381948992245419]
[null,"Weighted mode",0.724611353330463,0.426944110301011,1.22981345967091,"0.72(0.43-1.23)",0.238079775660746]
["Body mass index"]
[null,"MR Egger",0.651349259,0.550427621,0.770775013,"0.65(0.55-0.77)",8.5e-07]
[null,"Weighted median",0.897295493,0.833971248,0.965428008,"0.9(0.83-0.97)",0.003704872]
[null,"Inverse variance weighted",0.877788288,0.822417727,0.93688676,"0.88(0.82-0.94)",8.82e-05]
[null,"Simple mode",1.035387321,0.752734882,1.424175935,"1.04(0.75-1.42)",0.830804325]
[null,"Weighted mode",1.06915541,0.642808079,1.778280842,"1.07(0.64-1.78)",0.796826543]

{"sheet":"eTable 3","index":3,"n_rows":74,"n_cols":7,"rows_kept":74,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
[" The complementary MR analyses results of the causal effects of modifiable lifestyle factors  in ER+ BC."]
["Exposure","Method","or","or_lci95","or_uci95","Estimate","P"]
["Pack years of smoking"]
[null,"MR Egger",1.367259806,0.959853093,1.947589053,"1.37(0.96-1.95)",0.12132903]
[null,"Weighted median",1.063174801,0.873372353,1.294225371,"1.06(0.87-1.29)",0.541489808]
[null,"Inverse variance weighted",0.982981656,0.836501059,1.155112629,"0.98(0.84-1.16)",0.834843763]
[null,"Simple mode",0.929247707082649,0.613046689138618,1.40854084430609,"0.93(0.61-1.41)",0.737448098244964]
[null,"Weighted mode",1.09367386908484,0.886070042034477,1.34991871429556,"1.09(0.89-1.35)",0.426002074625719]
["Alcoholic drinks per week"]
[null,"MR Egger",0.957542162,0.692517127,1.323991791,"0.96(0.69-1.32)",0.794786858]
[null,"Weighted median",0.903513557,0.751459681,1.086334728,"0.9(0.75-1.09)",0.280494379]
[null,"Inverse variance weighted",1.023165985,0.82541214,1.26829808,"1.02(0.83-1.27)",0.834449761]
[null,"Simple mode",1.02064071687026,0.583835944746155,1.78424689727927,"1.02(0.58-1.78)",0.943308634788156]
[null,"Weighted mode",0.893454880449159,0.735832441892317,1.08484157255361,"0.89(0.74-1.08)",0.263978941083969]
["Physical activity"]
[null,"MR Egger",1.661913157,0.498942229,5.535621525,"1.66(0.5-5.54)",0.419444537]
[null,"Weighted median",1.073298238,0.730017699,1.578001614,"1.07(0.73-1.58)",0.719058524]
[null,"Inverse variance weighted",0.955537824,0.721056227,1.266270921,"0.96(0.72-1.27)",0.75154281]
[null,"Simple mode",1.3311921300676,0.66300062100875,2.67280667770375,"1.33(0.66-2.67)",0.43166555929899]
[null,"Weighted mode",1.37472421873196,0.707737520682423,2.67029318404078,"1.37(0.71-2.67)",0.359904705092522]
["Sleep duration"]
[null,"MR Egger",1.583836695,0.520633173,4.818245942,"1.58(0.52-4.82)",0.420873561]
[null,"Weighted median",1.52414491,1.131248565,2.05349892,"1.52(1.13-2.05)",0.005591753]
[null,"Inverse variance weighted",1.494953916,1.115698334,2.00312857,"1.49(1.12-2)",0.007074326]
[null,"Simple mode",1.31522684513269,0.681261812750735,2.53914372093334,"1.32(0.68-2.54)",0.417239991026093]
[null,"Weighted mode",1.48296574780727,0.92386930287753,2.38040965569466,"1.48(0.92-2.38)",0.107507734821986]
["Sleeplessness/insomnia"]
[null,"MR Egger",0.334182391,0.109564196,1.019291655,"0.33(0.11-1.02)",0.062445489]
[null,"Weighted median",0.641197826,0.431854346,0.95202157,"0.64(0.43-0.95)",0.027537237]
[null,"Inverse variance weighted",0.909511065,0.642090387,1.288308305,"0.91(0.64-1.29)",0.593390795]
[null,"Simple mode",0.484006581538814,0.214331123402704,1.09299278263352,"0.48(0.21-1.09)",0.0895763635364864]
[null,"Weighted mode",0.498392638624012,0.284596827583925,0.872796876702204,"0.5(0.28-0.87)",0.020085231552816]
["Years of schooling"]
[null,"MR Egger",0.791434799,0.534384211,1.172132386,"0.79(0.53-1.17)",0.244028154]
[null,"Weighted median",0.952084389,0.848882088,1.067833446,"0.95(0.85-1.07)",0.401577724]
[null,"Inverse variance weighted",0.944189415,0.855042729,1.042630528,"0.94(0.86-1.04)",0.256393084]
[null,"Simple mode",0.931944007583314,0.613066601515134,1.41668071808836,"0.93(0.61-1.42)",0.74174263620207]
[null,"Weighted mode",0.995870650856059,0.67478397222626,1.46974201234277,"1(0.67-1.47)",0.983390003100614]
["household income"]
[null,"MR Egger",1.507174548,0.566654234,4.008749923,"1.51(0.57-4.01)",0.41564133]
[null,"Weighted median",1.285255081,1.049499834,1.573969399,"1.29(1.05-1.57)",0.015211765]
[null,"Inverse variance weighted",1.103528783,0.872126255,1.396329679,"1.1(0.87-1.4)",0.411945893]
[null,"Simple mode",1.30387873697569,0.841721598827556,2.01978868441229,"1.3(0.84-2.02)",0.241076959567946]
[null,"Weighted mode",1.30387873697569,0.885339571572901,1.92027987376291,"1.3(0.89-1.92)",0.186025360970134]
["Coffee intake"]
[null,"MR Egger",0.965743263,0.473680153,1.968965859,"0.97(0.47-1.97)",0.924158215]
[null,"Weighted median",0.876992396,0.640155546,1.201451222,"0.88(0.64-1.2)",0.413778587]
[null,"Inverse variance weighted",0.756851854,0.531381323,1.07799184,"0.76(0.53-1.08)",0.122630632]
[null,"Simple mode",0.791723756606687,0.412317855817832,1.5202506947755,"0.79(0.41-1.52)",0.487561081242001]
[null,"Weighted mode",1.02510208359001,0.781462207086925,1.3447026257326,"1.03(0.78-1.34)",0.858925183442323]
["Processed meat intake"]
[null,"MR Egger",0.564633142,0.087683631,3.63591907,"0.56(0.09-3.64)",0.553932686]
[null,"Weighted median",0.911974573,0.614309834,1.353873202,"0.91(0.61-1.35)",0.647608992]
[null,"Inverse variance weighted",1.165207079,0.808640268,1.679000654,"1.17(0.81-1.68)",0.412004316]
[null,"Simple mode",0.729071988508111,0.268404301794233,1.98039286581431,"0.73(0.27-1.98)",0.541773318934752]
[null,"Weighted mode",0.830471718970713,0.354676670904465,1.94454085252183,"0.83(0.35-1.94)",0.672849490851636]
["Tea intake"]
[null,"MR Egger",0.994979093,0.547809858,1.807166082,"0.99(0.55-1.81)",0.986899362]
[null,"Weighted median",1.148302649,0.909153578,1.45035889,"1.15(0.91-1.45)",0.245790748]
[null,"Inverse variance weighted",1.180635736,0.910331718,1.531200896,"1.18(0.91-1.53)",0.210647106]
[null,"Simple mode",1.25446914445485,0.810137393258521,1.9425011701529,"1.25(0.81-1.94)",0.315951367372351]
[null,"Weighted mode",1.18380633830113,0.890277402834371,1.57411323946929,"1.18(0.89-1.57)",0.253045196377837]
["Fresh fruit intake"]
[null,"MR Egger",0.256793088,0.070642565,0.933469652,"0.26(0.07-0.93)",0.044068469]
[null,"Weighted median",0.647746559,0.435164511,0.964176982,"0.65(0.44-0.96)",0.032374674]
[null,"Inverse variance weighted",0.650789239,0.443849258,0.954212778,"0.65(0.44-0.95)",0.027804255]
[null,"Simple mode",0.665759246337633,0.304954140134773,1.45344927564573,"0.67(0.3-1.45)",0.311849905720387]
[null,"Weighted mode",0.653286816933099,0.364828533426117,1.16981986351408,"0.65(0.36-1.17)",0.158039006479101]
["Body mass index"]
[null,"MR Egger",0.707482508,0.587431539,0.852067799,"0.71(0.59-0.85)",0.000294951]
[null,"Weighted median",0.867651747,0.798221772,0.943120797,"0.87(0.8-0.94)",0.000849362]
[null,"Inverse variance weighted",0.890068008,0.828660278,0.956026347,"0.89(0.83-0.96)",0.001408261]
[null,"Simple mode",0.922879997540848,0.669180704724677,1.27276157822186,"0.92(0.67-1.27)",0.62481864350959]
[null,"Weighted mode",0.784690928419481,0.578415446486161,1.06452871700507,"0.78(0.58-1.06)",0.119877857922043]

{"sheet":"eTable 4","index":4,"n_rows":74,"n_cols":7,"rows_kept":74,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
[" The complementary MR analyses results of the causal effects of modifiable lifestyle factors  in  ER- BC."]
["Exposure","Method","or","or_lci95","or_uci95","Estimate","P"]
["Pack years of smoking"]
[null,"MR Egger",0.779197287,0.522768356,1.16141003,"0.78(0.52-1.16)",0.230038669]
[null,"Weighted median",0.838270249,0.628901247,1.117340783,"0.84(0.63-1.12)",0.228880417]
[null,"Inverse variance weighted",1.061222914,0.798867369,1.409738483,"1.06(0.8-1.41)",0.681717453]
[null,"Simple mode",1.09033068033943,0.648840709806653,1.83222318593987,"1.09(0.65-1.83)",0.751463837679657]
[null,"Weighted mode",1.03708285812026,0.745035571143827,1.44361007214146,"1.04(0.75-1.44)",0.833967597941922]
["Alcoholic drinks per week"]
[null,"MR Egger",0.779197287,0.522768356,1.16141003,"0.78(0.52-1.16)",0.230038669]
[null,"Weighted median",0.838270249,0.628901247,1.117340783,"0.84(0.63-1.12)",0.228880417]
[null,"Inverse variance weighted",1.061222914,0.798867369,1.409738483,"1.06(0.8-1.41)",0.681717453]
[null,"Simple mode",1.09710475564784,0.57047784597573,2.10987832981741,"1.1(0.57-2.11)",0.783041117457421]
[null,"Weighted mode",0.864403556247157,0.653631242918321,1.1431422780782,"0.86(0.65-1.14)",0.314762068998699]
["Physical activity"]
[null,"MR Egger",2.502943839,0.268822162,23.30435781,"2.5(0.27-23.3)",0.431396086]
[null,"Weighted median",0.700356021,0.384181593,1.276736225,"0.7(0.38-1.28)",0.24500817]
[null,"Inverse variance weighted",0.694389357,0.413592938,1.165824015,"0.69(0.41-1.17)",0.16770066]
[null,"Simple mode",0.414380176503396,0.126273654053993,1.35983180312153,"0.41(0.13-1.36)",0.163422170820038]
[null,"Weighted mode",0.566901888762914,0.198422335467212,1.61966519911295,"0.57(0.2-1.62)",0.303305424451525]
["Sleep duration"]
[null,"MR Egger",0.667011506,0.167502864,2.656099954,"0.67(0.17-2.66)",0.567716433]
[null,"Weighted median",1.240522366,0.823487368,1.868754518,"1.24(0.82-1.87)",0.30253824]
[null,"Inverse variance weighted",1.287757936,0.89254559,1.857967281,"1.29(0.89-1.86)",0.176311974]
[null,"Simple mode",1.57657998778498,0.698758640687696,3.55717169441773,"1.58(0.7-3.56)",0.276865903220155]
[null,"Weighted mode",1.35090472495202,0.675857784842155,2.70018873323167,"1.35(0.68-2.7)",0.397765791873394]
["Sleeplessness/insomnia"]
[null,"MR Egger",0.386454134,0.109815007,1.359985326,"0.39(0.11-1.36)",0.147807416]
[null,"Weighted median",1.055420484,0.606741444,1.835893046,"1.06(0.61-1.84)",0.848546963]
[null,"Inverse variance weighted",1.311937648,0.886114249,1.942391057,"1.31(0.89-1.94)",0.175069988]
[null,"Simple mode",0.739659650696455,0.186874722389947,2.92761049686961,"0.74(0.19-2.93)",0.670096486785506]
[null,"Weighted mode",0.595670697847628,0.171896048852066,2.06417531202036,"0.6(0.17-2.06)",0.419434289683406]
["Years of schooling"]
[null,"MR Egger",0.492031511,0.288618835,0.838805297,"0.49(0.29-0.84)",0.009639384]
[null,"Weighted median",0.75981915,0.634769676,0.90950334,"0.76(0.63-0.91)",0.002754117]
[null,"Inverse variance weighted",0.731288111,0.639036521,0.836857181,"0.73(0.64-0.84)",5.4e-06]
[null,"Simple mode",0.705556330618494,0.361840637394785,1.37577066871209,"0.71(0.36-1.38)",0.306846119697393]
[null,"Weighted mode",0.81470312503367,0.447791920166235,1.48225359156374,"0.81(0.45-1.48)",0.502674354803275]
["household income"]
[null,"MR Egger",1.017401681,0.324283906,3.191975183,"1.02(0.32-3.19)",0.976544072]
[null,"Weighted median",1.054972414,0.772235389,1.44122739,"1.05(0.77-1.44)",0.73671809]
[null,"Inverse variance weighted",0.881595549,0.671041969,1.158214758,"0.88(0.67-1.16)",0.36541325]
[null,"Simple mode",1.3123393506477,0.668946436562879,2.57454779205859,"1.31(0.67-2.57)",0.433423003315888]
[null,"Weighted mode",1.20088062901202,0.655117934756822,2.20130484699923,"1.2(0.66-2.2)",0.556837847769829]
["Coffee intake"]
[null,"MR Egger",1.129610901,0.449616669,2.838019304,"1.13(0.45-2.84)",0.796970877]
[null,"Weighted median",1.064290377,0.67994067,1.665901243,"1.06(0.68-1.67)",0.785188873]
[null,"Inverse variance weighted",0.672165733,0.422484437,1.069404535,"0.67(0.42-1.07)",0.093588047]
[null,"Simple mode",0.331094990688667,0.109899752511451,0.997489897419981,"0.33(0.11-1)",0.0574551937237145]
[null,"Weighted mode",1.25178653847775,0.870440613103769,1.80020269542192,"1.25(0.87-1.8)",0.233831203977029]
["Processed meat intake"]
[null,"MR Egger",0.51349166,0.048046638,5.487869635,"0.51(0.05-5.49)",0.587156134]
[null,"Weighted median",1.944894473,1.095270815,3.453588336,"1.94(1.1-3.45)",0.023169638]
[null,"Inverse variance weighted",1.780171192,1.11466779,2.843008026,"1.78(1.11-2.84)",0.015757287]
[null,"Simple mode",2.81959890041093,1.03083270653611,7.71234547447879,"2.82(1.03-7.71)",0.0558204563907689]
[null,"Weighted mode",2.64485041766488,1.03594433486976,6.75251893018128,"2.64(1.04-6.75)",0.0542010548638678]
["Tea intake"]
[null,"MR Egger",1.138216876,0.453020001,2.85978026,"1.14(0.45-2.86)",0.784519449]
[null,"Weighted median",1.237925762,0.875791614,1.749800028,"1.24(0.88-1.75)",0.226723711]
[null,"Inverse variance weighted",1.305122777,0.87506209,1.946542402,"1.31(0.88-1.95)",0.191672542]
[null,"Simple mode",1.30075825968499,0.615268228646217,2.74997467992389,"1.3(0.62-2.75)",0.49537395908582]
[null,"Weighted mode",1.21952969663905,0.865086886283838,1.71919457405411,"1.22(0.87-1.72)",0.264396536532665]
["Fresh fruit intake"]
[null,"MR Egger",0.353751621,0.047502085,2.634415079,"0.35(0.05-2.63)",0.315175672]
[null,"Weighted median",0.488255833,0.269161487,0.885690449,"0.49(0.27-0.89)",0.018299035]
[null,"Inverse variance weighted",0.550731371,0.307040251,0.987834796,"0.55(0.31-0.99)",0.045385931]
[null,"Simple mode",0.463009033477182,0.129801983650428,1.65157233389297,"0.46(0.13-1.65)",0.240724828319275]
[null,"Weighted mode",0.477839843600422,0.189334109714688,1.20596820338476,"0.48(0.19-1.21)",0.124003401912633]
["Body mass index"]
[null,"MR Egger",0.526026433,0.412354664,0.671033536,"0.53(0.41-0.67)",3.46e-07]
[null,"Weighted median",0.803553622,0.706203965,0.914322851,"0.8(0.71-0.91)",0.000901922]
[null,"Inverse variance weighted",0.839127136,0.763585604,0.922141993,"0.84(0.76-0.92)",0.000268363]
[null,"Simple mode",0.940408085246293,0.573059537467965,1.54323819598943,"0.94(0.57-1.54)",0.808016554529181]
[null,"Weighted mode",0.761233428276081,0.50149167228938,1.1555053938973,"0.76(0.5-1.16)",0.200756308108565]

{"sheet":"eTable 5","index":5,"n_rows":74,"n_cols":7,"rows_kept":74,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
[" The complementary MR analyses results of the causal effects of modifiable lifestyle factors  in benign neoplasm of breast."]
["Exposure","Method","or","or_lci95","or_uci95","Estimate","P"]
["Pack years of smoking"]
[null,"MR Egger",9.564801553,2.038347268,44.88216025,"9.56(2.04-44.88)",0.021058317]
[null,"Weighted median",2.572529934,1.059409823,6.246789601,"2.57(1.06-6.25)",0.03684293]
[null,"Inverse variance weighted",1.272573134,0.546512381,2.963230911,"1.27(0.55-2.96)",0.576200883]
[null,"Simple mode",1.53981664544243,0.275460451491195,8.60753436199668,"1.54(0.28-8.61)",0.634757065548748]
[null,"Weighted mode",2.38919647831579,0.964187427538309,5.92028027846251,"2.39(0.96-5.92)",0.0926246833664455]
["Alcoholic drinks per week"]
[null,"MR Egger",1.007849594,0.174595202,5.817804801,"1.01(0.17-5.82)",0.993079483]
[null,"Weighted median",1.15081357,0.374531674,3.536074423,"1.15(0.37-3.54)",0.806252784]
[null,"Inverse variance weighted",0.69188351,0.319563299,1.497990518,"0.69(0.32-1.5)",0.349995385]
[null,"Simple mode",0.963355259169925,0.121891428966431,7.61377041224075,"0.96(0.12-7.61)",0.971977648523306]
[null,"Weighted mode",1.35325918147561,0.316773789594633,5.78112985481377,"1.35(0.32-5.78)",0.685667955353647]
["Physical activity"]
[null,"MR Egger",16.64393719,0.178371098,1553.057913,"16.64(0.18-1553.06)",0.240935599]
[null,"Weighted median",2.719120334,0.654803303,11.29135323,"2.72(0.65-11.29)",0.168484034]
[null,"Inverse variance weighted",3.127888233,1.072406986,9.123108042,"3.13(1.07-9.12)",0.036798075]
[null,"Simple mode",1.68865568936765,0.120195152004853,23.7244014394076,"1.69(0.12-23.72)",0.702128874900808]
[null,"Weighted mode",2.54186783157361,0.224795067441486,28.7421434408055,"2.54(0.22-28.74)",0.460676699942369]
["Sleep duration"]
[null,"MR Egger",0.382557052,0.020256495,7.224838247,"0.38(0.02-7.22)",0.523752345]
[null,"Weighted median",1.398594238,0.439315721,4.452528672,"1.4(0.44-4.45)",0.570169877]
[null,"Inverse variance weighted",1.282124053,0.609264322,2.698077054,"1.28(0.61-2.7)",0.512674052]
[null,"Simple mode",2.98897815275611,0.246984227206286,36.1723114820264,"2.99(0.25-36.17)",0.39242160443325]
[null,"Weighted mode",1.81832850971952,0.258830323389159,12.7740773413464,"1.82(0.26-12.77)",0.549746784911054]
["Sleeplessness/insomnia"]
[null,"MR Egger",3.033516878,0.109493277,84.04374155,"3.03(0.11-84.04)",0.516634721]
[null,"Weighted median",2.657944291,0.578859199,12.20446676,"2.66(0.58-12.2)",0.208748201]
[null,"Inverse variance weighted",1.185709626,0.385579458,3.64621944,"1.19(0.39-3.65)",0.766307186]
[null,"Simple mode",0.549255091822509,0.0305556652924348,9.87316600720997,"0.55(0.03-9.87)",0.686647294908058]
[null,"Weighted mode",2.78374030764642,0.34397530324106,22.5283909263239,"2.78(0.34-22.53)",0.343291011349142]
["Years of schooling"]
[null,"MR Egger",0.317032804,0.045954314,2.187167849,"0.32(0.05-2.19)",0.244617716]
[null,"Weighted median",0.464883702,0.217220159,0.994920809,"0.46(0.22-0.99)",0.048482208]
[null,"Inverse variance weighted",0.469789576,0.28671276,0.769767783,"0.47(0.29-0.77)",0.002712208]
[null,"Simple mode",0.467015117283724,0.103882791653474,2.09951153891845,"0.47(0.1-2.1)",0.321579021564457]
[null,"Weighted mode",0.508746982616261,0.158954336918266,1.6282883332352,"0.51(0.16-1.63)",0.255764752089665]
["household income"]
[null,"MR Egger",0.029317005,0.001610726,0.533602009,"0.03(0-0.53)",0.021594674]
[null,"Weighted median",0.870914263,0.384775672,1.971256781,"0.87(0.38-1.97)",0.740175975]
[null,"Inverse variance weighted",1.123309944,0.618127202,2.041368228,"1.12(0.62-2.04)",0.702804171]
[null,"Simple mode",0.869213488722586,0.169098419351352,4.46800207757974,"0.87(0.17-4.47)",0.867500129025104]
[null,"Weighted mode",0.841749834604351,0.20815432526713,3.40393015205022,"0.84(0.21-3.4)",0.810163145008785]
["Coffee intake"]
[null,"MR Egger",0.868985037,0.195827924,3.856114993,"0.87(0.2-3.86)",0.854489426]
[null,"Weighted median",0.829921097,0.303259131,2.271222719,"0.83(0.3-2.27)",0.716645987]
[null,"Inverse variance weighted",0.908933137,0.433376351,1.906332557,"0.91(0.43-1.91)",0.800518735]
[null,"Simple mode",1.00980039383203,0.142047010402031,7.17858709238102,"1.01(0.14-7.18)",0.99227632539873]
[null,"Weighted mode",0.844596314625687,0.273021788460164,2.61276925443398,"0.84(0.27-2.61)",0.771058364875125]
["Processed meat intake"]
[null,"MR Egger",16.25461858,0.052694847,5014.012554,"16.25(0.05-5014.01)",0.351173431]
[null,"Weighted median",3.562024036,0.80784073,15.70608508,"3.56(0.81-15.71)",0.093325557]
[null,"Inverse variance weighted",3.840645533,1.246256086,11.83589655,"3.84(1.25-11.84)",0.019110399]
[null,"Simple mode",4.88497200884451,0.273690606124956,87.1895161659273,"4.88(0.27-87.19)",0.292383811534551]
[null,"Weighted mode",8.83834772109551,0.619593486286212,126.076842587899,"8.84(0.62-126.08)",0.122316066761184]
["Tea intake"]
[null,"MR Egger",0.580188737,0.130295026,2.583513587,"0.58(0.13-2.58)",0.479331778]
[null,"Weighted median",0.73734586,0.285923316,1.901485073,"0.74(0.29-1.9)",0.528426338]
[null,"Inverse variance weighted",0.73961624,0.37718322,1.450308905,"0.74(0.38-1.45)",0.379994374]
[null,"Simple mode",0.228919080503853,0.0367156045539063,1.42729354603952,"0.23(0.04-1.43)",0.122418135267154]
[null,"Weighted mode",0.793087863740028,0.262254684136742,2.3983875128185,"0.79(0.26-2.4)",0.683618109679035]
["Fresh fruit intake"]
[null,"MR Egger",0.076032106,0.001864474,3.100542449,"0.08(0-3.1)",0.179217695]
[null,"Weighted median",0.680006531,0.132853606,3.480589636,"0.68(0.13-3.48)",0.64342233]
[null,"Inverse variance weighted",0.62151354,0.209216195,1.846315393,"0.62(0.21-1.85)",0.391912741]
[null,"Simple mode",0.0957846835804575,0.00182069213764944,5.03913067942015,"0.1(0-5.04)",0.251293160879079]
[null,"Weighted mode",0.0565595668709637,0.000712007038921216,4.4929114878947,"0.06(0-4.49)",0.203837622383421]
["Body mass index"]
[null,"MR Egger",0.627494662,0.361250848,1.089961595,"0.63(0.36-1.09)",0.098737534]
[null,"Weighted median",0.834996416,0.604820771,1.152769627,"0.83(0.6-1.15)",0.273095373]
[null,"Inverse variance weighted",0.86423661,0.701174941,1.065219069,"0.86(0.7-1.07)",0.171391352]
[null,"Simple mode",1.00360466824636,0.367110028174647,2.74365245518904,"1(0.37-2.74)",0.994407768172402]
[null,"Weighted mode",0.911268018741552,0.507655423842375,1.63577372166321,"0.91(0.51-1.64)",0.755709552717724]

{"sheet":"eTable 6","index":6,"n_rows":74,"n_cols":7,"rows_kept":74,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
[" The complementary MR analyses results of the causal effects of modifiable lifestyle factors  in inflammatory disorders of breast."]
["Exposure","Method","or","or_lci95","or_uci95","Estimate","P"]
["Pack years of smoking"]
[null,"MR Egger",1.704378368,0.068615242,42.33615658,"1.7(0.07-42.34)",0.753283715]
[null,"Weighted median",3.414143879,0.821522314,14.1887545,"3.41(0.82-14.19)",0.091122987]
[null,"Inverse variance weighted",4.175035749,1.110340666,15.69871665,"4.18(1.11-15.7)",0.03443919]
[null,"Simple mode",1.98846909651445,0.208117039820078,18.9989697682194,"1.99(0.21-19)",0.565279657532445]
[null,"Weighted mode",3.12420718867757,0.750597309705723,13.0038709592649,"3.12(0.75-13)",0.151859524140442]
["Alcoholic drinks per week"]
[null,"MR Egger",17.72616564,0.997739413,314.9288723,"17.73(1-314.93)",0.058941086]
[null,"Weighted median",3.817175787,0.644710409,22.60058283,"3.82(0.64-22.6)",0.139879438]
[null,"Inverse variance weighted",3.296437134,0.939622499,11.56474838,"3.3(0.94-11.56)",0.062497753]
[null,"Simple mode",4.32110879581675,0.1589851334759,117.444825293148,"4.32(0.16-117.44)",0.391344318593153]
[null,"Weighted mode",3.09524424605275,0.277731135338335,34.4957252669979,"3.1(0.28-34.5)",0.365008417761058]
["Physical activity"]
[null,"MR Egger",0.054025286,3.59e-05,81.22595151,"0.05(0-81.23)",0.44503914]
[null,"Weighted median",1.82015092,0.181748576,18.22819985,"1.82(0.18-18.23)",0.610411416]
[null,"Inverse variance weighted",0.798391789,0.141635715,4.500485251,"0.8(0.14-4.5)",0.798578633]
[null,"Simple mode",3.11650154002896,0.0531514987407361,182.733922450225,"3.12(0.05-182.73)",0.590940857197181]
[null,"Weighted mode",2.77576232562916,0.0499543542242349,154.237935972442,"2.78(0.05-154.24)",0.624468354414475]
["Sleep duration"]
[null,"MR Egger",2.10589104,0.007871209,563.4175198,"2.11(0.01-563.42)",0.794771484]
[null,"Weighted median",0.552396552,0.079013414,3.861900586,"0.55(0.08-3.86)",0.549723688]
[null,"Inverse variance weighted",0.2500169,0.061179233,1.021726605,"0.25(0.06-1.02)",0.05359773]
[null,"Simple mode",0.0949968984003968,0.00100620143013093,8.96879137263905,"0.09(0-8.97)",0.313933897289746]
[null,"Weighted mode",1.02913971499546,0.0336452583415922,31.4792813367004,"1.03(0.03-31.48)",0.986916928155605]
["Sleeplessness/insomnia"]
[null,"MR Egger",35.51997033,0.338988117,3721.865842,"35.52(0.34-3721.87)",0.141017773]
[null,"Weighted median",6.975306179,0.573214307,84.88081286,"6.98(0.57-84.88)",0.127631046]
[null,"Inverse variance weighted",2.874444135,0.5823679,14.1876451,"2.87(0.58-14.19)",0.194888226]
[null,"Simple mode",10.3467479604703,0.0924862057804108,1157.52605974211,"10.35(0.09-1157.53)",0.337760208152926]
[null,"Weighted mode",9.59715130950427,0.308085114903019,298.960607968721,"9.6(0.31-298.96)",0.205209786198384]
["Years of schooling"]
[null,"MR Egger",0.317032804,0.045954314,2.187167849,"0.32(0.05-2.19)",0.244617716]
[null,"Weighted median",0.464883702,0.221211666,0.976968621,"0.46(0.22-0.98)",0.043228669]
[null,"Inverse variance weighted",0.469789576,0.28671276,0.769767783,"0.47(0.29-0.77)",0.002712208]
[null,"Simple mode",0.448202323079464,0.0467677568321725,4.29538074991947,"0.45(0.05-4.3)",0.486981244807915]
[null,"Weighted mode",0.479345910542136,0.0638426048498334,3.59904647521707,"0.48(0.06-3.6)",0.475215606731879]
["household income"]
[null,"MR Egger",0.466421138,0.004184492,51.98926226,"0.47(0-51.99)",0.7526846]
[null,"Weighted median",0.826266077,0.228108806,2.992938514,"0.83(0.23-2.99)",0.771349075]
[null,"Inverse variance weighted",0.654636001,0.260496621,1.645120356,"0.65(0.26-1.65)",0.367505934]
[null,"Simple mode",0.94906440307722,0.0907464045443156,9.92571822224049,"0.95(0.09-9.93)",0.965380300804865]
[null,"Weighted mode",1.04539714429559,0.105527145409284,10.3561522967647,"1.05(0.11-10.36)",0.969902147694488]
["Coffee intake"]
[null,"MR Egger",0.577794972,0.051746135,6.451632151,"0.58(0.05-6.45)",0.658567471]
[null,"Weighted median",1.359358026,0.245738137,7.519607115,"1.36(0.25-7.52)",0.724992546]
[null,"Inverse variance weighted",2.367763283,0.713577933,7.856609214,"2.37(0.71-7.86)",0.158971825]
[null,"Simple mode",1.0802956141628,0.0475482905285746,24.5442812140225,"1.08(0.05-24.54)",0.961603282128146]
[null,"Weighted mode",1.24011026938972,0.214325906714152,7.17539705686126,"1.24(0.21-7.18)",0.811443398019227]
["Processed meat intake"]
[null,"MR Egger",0.0045002,{"v":3.92e-07,"d":"3.92E-07"},51.64250522,"0(0-51.64)",0.269990746]
[null,"Weighted median",0.702314283,0.070569685,6.989479285,"0.7(0.07-6.99)",0.763088725]
[null,"Inverse variance weighted",0.46409966,0.072149365,2.985313803,"0.46(0.07-2.99)",0.418896961]
[null,"Simple mode",0.650488731687687,0.00870368816507386,48.6156652246128,"0.65(0.01-48.62)",0.846889344795002]
[null,"Weighted mode",0.78152908070746,0.0125057830206188,48.8404207065177,"0.78(0.01-48.84)",0.908045943757206]
["Tea intake"]
[null,"MR Egger",1.186853085,0.137777584,10.22387103,"1.19(0.14-10.22)",0.876922461]
[null,"Weighted median",1.480865312,0.34175786,6.416712913,"1.48(0.34-6.42)",0.599701044]
[null,"Inverse variance weighted",0.893588134,0.335154851,2.382480068,"0.89(0.34-2.38)",0.822079674]
[null,"Simple mode",1.61207271873671,0.122816306021721,21.1598812460259,"1.61(0.12-21.16)",0.718171864021946]
[null,"Weighted mode",1.30778209608536,0.284129799404795,6.01941089749897,"1.31(0.28-6.02)",0.732321747247074]
["Fresh fruit intake"]
[null,"MR Egger",418.2030854,1.223156441,142985.6515,"418.2(1.22-142985.65)",0.047834509]
[null,"Weighted median",0.482876192,0.037280203,6.254510441,"0.48(0.04-6.25)",0.577466806]
[null,"Inverse variance weighted",1.806386199,0.320057436,10.19514228,"1.81(0.32-10.2)",0.503037289]
[null,"Simple mode",0.272461750661402,0.00115789833769893,64.1121963444589,"0.27(0-64.11)",0.642676294038526]
[null,"Weighted mode",0.444673593930419,0.00538499516104213,36.7195511278284,"0.44(0.01-36.72)",0.720394092894408]
["Body mass index"]
[null,"MR Egger",1.323409941,0.560723446,3.123489637,"1.32(0.56-3.12)",0.522764666]
[null,"Weighted median",1.969367976,1.163966731,3.332062781,"1.97(1.16-3.33)",0.011540275]
[null,"Inverse variance weighted",1.966744537,1.421498448,2.721131407,"1.97(1.42-2.72)",{"v":4.44e-05,"d":"4.44E-05"}]
[null,"Simple mode",1.7788677781253,0.294020051440518,10.7624311898082,"1.78(0.29-10.76)",0.530861959615338]
[null,"Weighted mode",1.03122377575791,0.323742516683671,3.28477855359192,"1.03(0.32-3.28)",0.958538054889605]