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["Acute myocardial infarction","COPD","rs248454","A","G","A","G",0.000729313,-0.0166,0.678165,0.5997,false,false,5,150579590,0.0191,"NA",0.3862,150579590,0.000157756,{"v":3.8e-6,"d":"3.80E-06"},463010,21.37244765]
["Acute myocardial infarction","COPD","rs2859266","C","A","C","A",-0.000772278,{"v":0.0008,"d":"8.00E-04"},0.746367,0.6864,false,false,12,121075606,0.0202,"NA",0.97,121075606,0.000168703,{"v":4.7e-6,"d":"4.70E-06"},463010,20.95558742]
["Acute myocardial infarction","COPD","rs36133328","G","A","G","A",-0.00104752,0.0095,0.153092,0.1649,false,false,1,104076990,0.0251,"NA",0.706801,104076990,0.000210769,{"v":6.7e-7,"d":"6.70E-07"},463010,24.70070228]
["Acute myocardial infarction","COPD","rs4527238","C","T","C","T",-0.000712039,0.0194,0.418624,0.4465,false,false,2,69319791,0.0186,"NA",0.2977,69319791,0.000149459,{"v":1.9e-6,"d":"1.90E-06"},463010,22.69663863]
["Acute myocardial infarction","COPD","rs660240","C","T","C","T",0.000845312,0.0123,0.784825,0.7867,false,false,1,109817838,0.0227,"NA",0.587,109817838,0.000178649,{"v":2.2e-6,"d":"2.20E-06"},463010,22.38881014]
["Acute myocardial infarction","COPD","rs7550876","A","C","A","C",0.000832413,-0.0062,0.23656,0.2491,false,false,1,222280229,0.0216,"NA",0.7728,222280229,0.000174466,{"v":1.8e-6,"d":"1.80E-06"},463010,22.764296]
["Acute myocardial infarction","COPD","rs816237","A","C","A","C",0.000731289,-0.021,0.328891,0.3629,false,false,7,56205384,0.0193,"NA",0.276,56205384,0.000156271,{"v":2.9e-6,"d":"2.90E-06"},463010,21.89875492]

{"sheet":"2.MR result","index":1,"n_rows":22,"n_cols":10,"rows_kept":22,"merged":[[0,0,0,9]]}
["Estimated association between COPD, ischemic stroke and acute myocardial infarction by mendelian randomization"]
["exposure","outcome","method","nsnp","b","se","pval","or","or_lci95","or_uci95"]
["COPD","Ischemic stroke (large artery atherosclerosis) ","MR Egger",19,0.123762001726245,0.120397904828243,0.318382119628231,1.13174648523396,0.893849473865679,1.43295951308228]
["COPD","Ischemic stroke (large artery atherosclerosis) ","Weighted median",19,0.106592465833076,0.0908127816312751,0.240490926124106,1.11248078815287,0.931088836106633,1.32921097967874]
["COPD","Ischemic stroke (large artery atherosclerosis) ","Inverse variance weighted",19,0.141969097171008,0.0614551761471068,0.0208812722198371,1.15254103120828,1.02175011081945,1.30007407344766]
["COPD","Ischemic stroke (large artery atherosclerosis) ","Simple mode",19,0.10875280606075,0.151813300125826,0.482961324490416,1.11488672303527,0.82795103552415,1.5012631808757]
["COPD","Ischemic stroke (large artery atherosclerosis) ","Weighted mode",19,0.10164811937971,0.11522474724437,0.389312556015049,1.10699387349506,0.883209908005188,1.38747926721446]
["COPD","Acute myocardial infarction","MR Egger",7,0.00119273977325895,0.00428401419046068,0.79183970428678,1.00119345137023,0.992821958051746,1.00963553327694]
["COPD","Acute myocardial infarction","Weighted median",7,0.00103158103296041,0.000823334329268707,0.210230850525904,1.00103211329568,0.999418015166503,1.00264881825477]
["COPD","Acute myocardial infarction","Inverse variance weighted",7,0.00136299644592304,0.000626212465796183,0.0295125249231828,1.00136392574774,1.00013562920977,1.0025937307935]
["COPD","Acute myocardial infarction","Simple mode",7,0.000962611379812435,0.00101232250557612,0.378373340459588,1.00096307483885,0.998978980863991,1.00295110946608]
["COPD","Acute myocardial infarction","Weighted mode",7,0.00102726835017351,0.00107744776610897,0.377188241224231,1.00102779617103,0.998916058617923,1.00314399799864]
["Ischemic stroke (large artery atherosclerosis) ","COPD","MR Egger",33,-0.00512139594416055,0.0439110180116458,0.907904617265633,0.99489169604476,0.912847000540153,1.08431038966346]
["Ischemic stroke (large artery atherosclerosis) ","COPD","Weighted median",33,-0.0280308984801696,0.0320069353141868,0.381151943744551,0.972358321942751,0.913232759473772,1.03531185937321]
["Ischemic stroke (large artery atherosclerosis) ","COPD","Inverse variance weighted",33,-0.0138943979645342,0.0248335020660528,0.575819059741051,0.986201683669274,0.939349126644282,1.03539113763441]
["Ischemic stroke (large artery atherosclerosis) ","COPD","Simple mode",33,0.0211949708923054,0.053731059437265,0.695855258999569,1.02142117962363,0.919322856387455,1.13485835681651]
["Ischemic stroke (large artery atherosclerosis) ","COPD","Weighted mode",33,-0.0116024489756944,0.0369237234966597,0.755387801105473,0.988464599874609,0.919456129778549,1.06265240239422]
["Acute myocardial infarction","COPD","MR Egger",8,28.0405008240906,74.3619708759324,0.719090135730376,1506034004033.04,{"v":7.57961754785664e-52,"d":"7.58E-52"},{"v":2.992418030307e+75,"d":"2.99E+75"}]
["Acute myocardial infarction","COPD","Weighted median",8,-8.33172336669756,11.4348608919953,0.466231196752665,0.000240756774942001,{"v":4.44660368047505e-14,"d":"4.45E-14"},1303552.75274455]
["Acute myocardial infarction","COPD","Inverse variance weighted",8,-10.5400695486823,9.22370926281696,0.253157002068668,{"v":2.64548897602837e-5,"d":"2.65E-05"},{"v":3.72499870849627e-13,"d":"3.72E-13"},1878.82264397156]
["Acute myocardial infarction","COPD","Simple mode",8,-5.66199981387896,18.0140945628508,0.762446624041169,0.0034755594716827,{"v":1.6110828278785e-18,"d":"1.61E-18"},7497760780623.43]
["Acute myocardial infarction","COPD","Weighted mode",8,-6.2303152435157,17.3048465731737,0.729440166210967,0.00196883113755009,{"v":3.66459251723435e-18,"d":"3.66E-18"},1057770005793.77]

{"sheet":"3. heterogeneity-Q","index":2,"n_rows":10,"n_cols":6,"rows_kept":10,"merged":[[0,0,0,5]]}
["Detection of heterogeneity by Q statistics"]
["exposure","outcome","method","Q","Q_df","Q_pval"]
["COPD","Ischemic stroke (large artery atherosclerosis) ","MR Egger",15.5199430290506,17,0.558084219722924]
["COPD","Ischemic stroke (large artery atherosclerosis) ","Inverse variance weighted",15.5508695051449,18,0.623860254581426]
["COPD","Acute myocardial infarction","MR Egger",2.14935365932595,5,0.828116966171013]
["COPD","Acute myocardial infarction","Inverse variance weighted",2.1509675963459,6,0.905303523674002]
["Ischemic stroke (large artery atherosclerosis) ","COPD","MR Egger",43.0586662073302,31,0.0734106063319255]
["Ischemic stroke (large artery atherosclerosis) ","COPD","Inverse variance weighted",43.1413582224876,32,0.0903103687271875]
["Acute myocardial infarction","COPD","MR Egger",1.97016759073682,6,0.922421721419168]
["Acute myocardial infarction","COPD","Inverse variance weighted",2.24354916692403,7,0.945140481379704]

{"sheet":"4. Egger intercept ","index":3,"n_rows":6,"n_cols":5,"rows_kept":6,"merged":[[0,0,0,4]]}
["Detection of horizontal pleiotropy by Egger intercept"]
["exposure","outcome","egger_intercept","se","pval"]
["COPD","Ischemic stroke (large artery atherosclerosis) ",0.00313241218959041,0.0178120410227243,0.862482329624334]
["COPD","Acute myocardial infarction",{"v":1.74347264684263e-5,"d":"1.74E-05"},0.000433982129441607,0.96950932831301]
["Ischemic stroke (large artery atherosclerosis) ","COPD",-0.0032222704378147,0.0132062537803578,0.808841707374383]
["Acute myocardial infarction","COPD",-0.0303679546719242,0.0580805768327224,0.619809853549571]

{"sheet":"5. MR-PRESSO global test","index":4,"n_rows":6,"n_cols":4,"rows_kept":6,"merged":[[0,0,0,3]]}
["Detection of pleiotropy by MR-PRESSO global test"]
["exposure","outcome","Global Test RSSobs","P"]
["COPD","Ischemic stroke (large artery atherosclerosis) ",17.07994,0.6358]
["COPD","Acute myocardial infarction",2.785657,0.9212]
["Ischemic stroke (large artery atherosclerosis) ","COPD",45.17402,0.111]
["Acute myocardial infarction","COPD",2.902857,0.9462]