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["Table S1. Summary of immune checkpoint genes collections."]
["Symbol","Type","Role with Immunity","Expression pattern demenstrate from FANTOM5 data","Family","Ligand receptor pairs"]
["BTN2A2","Ligand","Inhibit","TIC-ICGs","BTN","NA"]
["BTNL3","Ligand","TwoSide","TIC-ICGs","BTN","NA"]
["BTNL9","Ligand","TwoSide","TIC-ICGs","BTN","NA"]
["CEACAM1","Ligand&Receptor","Activate","TIC-ICGs","Other","NA"]
["IDO1","Ligand","Inhibit","TIC-ICGs","Other","NA"]
["TDO2","Ligand","Inhibit","TIC-ICGs","Other","NA"]
["VTCN1","Ligand","Inhibit","TIC-ICGs","Other","NA"]
["ADORA2A","Receptor","Inhibit","IC-ICGs","Other","NA"]
["BTN3A1","Ligand","Activate","IC-ICGs","BTN","NA"]
["C10orf54","Ligand","Inhibit","IC-ICGs","Other","NA"]
["CD276","Ligand","Inhibit","TC-ICGs","Other","NA"]
["CD274","Ligand","TwoSide","TIC-ICGs","Other","Pair 1"]
["PDCD1LG2","Ligand","TwoSide","TIC-ICGs","Other","Pair 1"]
["PDCD1","Receptor","Inhibit","IC-ICGs","Other","Pair 1"]
["CD28","Receptor","Activate","IC-ICGs","Other","Pair 2"]
["CD80","Ligand","TwoSide","IC-ICGs","Other","Pair 2"]
["CD86","Ligand","TwoSide","IC-ICGs","Other","Pair 2"]
["CTLA4","Receptor","Inhibit","IC-ICGs","Other","Pair 2"]
["ICOS","Receptor","Activate","IC-ICGs","Other","Pair 3"]
["ICOSLG","Ligand","Activate","N","Other","Pair 3"]
["CD160","Ligand","Inhibit","TIC-ICGs","Other","Pair 4"]
["BTLA","Receptor","Inhibit","IC-ICGs","Other","Pair 4"]
["TNFRSF14","Ligand","TwoSide","IC-ICGs","Other","Pair 4"]
["TNFSF14","Ligand","Activate","IC-ICGs","Other","Pair 4"]
["TNFSF9","Ligand","Activate","TIC-ICGs","Other","Pair 5"]
["TNFRSF9","Receptor","Activate","IC-ICGs","Other","Pair 5"]
["TNFSF4","Ligand","Activate","TIC-ICGs","Other","Pair 6"]
["TNFRSF4","Receptor","Activate","IC-ICGs","Other","Pair 6"]
["CD70","Ligand","Activate","TIC-ICGs","Other","Pair 7"]
["CD27","Receptor","Activate","IC-ICGs","Other","Pair 7"]
["CD40","Receptor","Activate","IC-ICGs","Other","Pair 8"]
["CD40LG","Ligand","Activate","IC-ICGs","Other","Pair 8"]
["HAVCR2","Receptor","Inhibit","TIC-ICGs","Other","Pair 9"]
["LGALS9","Ligand","Inhibit","IC-ICGs","Other","Pair 9"]
["TNFSF18","Ligand","Activate","TIC-ICGs","Other","Pair 10"]
["TNFRSF18","Receptor","Activate","IC-ICGs","Other","Pair 10"]
["CD47","Ligand","Inhibit","TIC-ICGs","Other","Pair 11"]
["SIRPA","Receptor","Inhibit","IC-ICGs","Other","Pair 11"]
["CD226","Receptor","Activate","IC-ICGs","Other","Pair 12"]
["CD96","Receptor","Activate","IC-ICGs","Other","Pair 12"]
["TIGIT","Receptor","Inhibit","IC-ICGs","Other","Pair 12"]
["PVR","Ligand","TwoSide","TC-ICGs","Other","Pair 12"]
["BTN2A1","Ligand","TwoSide","TIC-ICGs","BTN","Pair 13"]
["CD209","Ligand","TwoSide","TIC-ICGs","Other","Pair 13"]
["HLA-DOB","Ligand","TwoSide","TIC-ICGs","MHC class II","Pair 14"]
["HLA-G","Ligand","TwoSide","TIC-ICGs","MHC class I","Pair 14"]
["KIR2DL1","Receptor","Inhibit","TIC-ICGs","KIR_inhibit","Pair 14"]
["KIR2DL2","Receptor","Inhibit","TIC-ICGs","KIR_inhibit","Pair 14"]
["KIR2DL3","Receptor","Inhibit","TIC-ICGs","KIR_inhibit","Pair 14"]
["KIR2DL4","Receptor","Activate","TIC-ICGs","KIR_activate","Pair 14"]
["KIR2DS2","Receptor","Activate","TIC-ICGs","KIR_activate","Pair 14"]
["KIR3DL2","Receptor","Inhibit","TIC-ICGs","KIR_inhibit","Pair 14"]
["HLA-A","Ligand","TwoSide","IC-ICGs","MHC class I","Pair 14"]
["HLA-B","Ligand","TwoSide","IC-ICGs","MHC class I","Pair 14"]
["HLA-C","Ligand","TwoSide","IC-ICGs","MHC class I","Pair 14"]
["HLA-DMA","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DMB","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DOA","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DPA1","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DPB1","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DQA1","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DQB1","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DRA","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DRB1","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DRB4","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-DRB5","Ligand","TwoSide","IC-ICGs","MHC class II","Pair 14"]
["HLA-E","Ligand","TwoSide","IC-ICGs","MHC class I","Pair 14"]
["HLA-F","Ligand","TwoSide","IC-ICGs","MHC class I","Pair 14"]
["LAG3","Receptor","Inhibit","IC-ICGs","Other","Pair 14"]
["HLA-DRB3","Ligand","TwoSide","N","MHC class II","Pair 14"]
["KIR2DL5A","Receptor","Inhibit","N","KIR_inhibit","Pair 14"]
["KIR2DL5B","Receptor","Inhibit","N","KIR_inhibit","Pair 14"]
["KIR2DS1","Receptor","Activate","N","KIR_activate","Pair 14"]
["KIR2DS3","Receptor","Activate","N","KIR_activate","Pair 14"]
["KIR2DS4","Receptor","Activate","N","KIR_activate","Pair 14"]
["KIR2DS5","Receptor","Activate","N","KIR_activate","Pair 14"]
["KIR3DL1","Receptor","Inhibit","N","KIR_inhibit","Pair 14"]
["KIR3DL3","Receptor","Inhibit","N","KIR_inhibit","Pair 14"]
["KIR3DS1","Receptor","Activate","N","KIR_activate","Pair 14"]