{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Folha1"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Folha1","index":0,"n_rows":71,"n_cols":3,"rows_kept":71,"flags":["formulas_cached_only"]}
["Compound","SMILES","pIC50"]
["A1","COc1ccc(c(OC)c1)Nc2c3ccccc3sc2",4.06]
["A2","COc1ccc(c(OC)c1)Nc2c3ccccc3sc2C(=O)O",3.61]
["A3","COc1ccc(c(OC)c1)Nc2c3ccccc3sc2C(=O)OCC",3.77]
["A4","Oc1ccc(c(O)c1)Nc2c3ccccc3sc2C(=O)OCC",3.84]
["A5","Oc1ccccc1Nc2c3ccccc3sc2C(=O)OCC",3.91]
["A6","Fc1ccccc1Nc2c3ccccc3sc2",3.81]
["A7","COc1cc(OC)c(cc1)Nc3c(C)cc2c(sc(C)c2C)c3",4.07]
["A8","COc1ccc(cc1OC)Nc3c(C)cc2c(sc(C)c2C)c3",{"v":4.3,"d":"4.30"}]
["A9","COc1ccc(cc1)Nc3cc(C)c2c(sc(C)c2C)c3C",3.89]
["A10","COc1ccc(cc1)Nc3c(C)cc2c(sc(C)c2C)c3",4.14]
["A11","COc1cc(ccc1)Nc3c(C)cc2c(sc(C)c2C)c3",3.38]
["A12","O=Cc1ccc(cc1)Nc3c(C)cc2c(sc(C)c2C)c3",2.39]
["A13","N#Cc1ccc(cc1)Nc3cc(C)c2c(sc(C)c2C)c3C",2.29]
["A14","COc1cc(c(Br)cc1OC)Nc3c(C)cc2c(sc(C)c2C)c3",3.81]
["A15","COc1cc(Br)c(cc1)Nc3cc(C)c2c(sc(C)c2C)c3C",3.98]
["A16","COc1cc(Br)c(cc1)Nc3c(C)cc2c(sc(C)c2C)c3",3.69]
["A17","Brc1ccccc1Nc3c(C)cc2c(sc(C)c2C)c3",3.05]
["A18","Brc1ccccc1Nc3cc(C)c2c(sc(C)c2C)c3C",2.43]
["A19","Ic1ccccc1Nc3c(C)cc2c(sc(C)c2C)c3",2.91]
["A20","Cc1cc(c(C)c2sc(C)c(C)c12)Nc3ncccc3",{"v":2.1,"d":"2.10"}]
["A21","COc1ccc(cc1OC)Nc3cccc2c3sc(C)c2C",4.26]
["A22","COc1cc(ccc1)Nc3cccc2c3sc(C)c2C",2.81]
["A23","COc1ccc(cc1)Nc3cccc2c3sc(C)c2C",{"v":4.3,"d":"4.30"}]
["A24","N#Cc1cc(ccc1)Nc3cccc2c3sc(C)c2C",1.84]
["A25","Cc1c2cccc(c2sc1C)Nc3cccnc3",{"v":2.5,"d":"2.50"}]
["A26","Cc1c2cccc(c2sc1C)Nc3ccccn3",2.26]
["B1","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC(=C(C(=C4)F)F)F",{"v":4.7073,"d":"4.71"}]
["B2","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=CC=C4",{"v":4.4864,"d":"4.49"}]
["B3","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=CC=C4F",{"v":4.4284,"d":"4.43"}]
["B4","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=C(C=C4)F",{"v":4.5336,"d":"4.53"}]
["B5","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=C(C=CC=C4F)F",{"v":4.6615,"d":"4.66"}]
["B6","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=CC=C4C(F)(F)F",{"v":4.7073,"d":"4.71"}]
["B7","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=CC(=C4)C(F)(F)F",{"v":4.4495,"d":"4.45"}]
["B8","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F",{"v":4.0491,"d":"4.05"}]
["B9","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=CC=C4Cl",{"v":4.5157,"d":"4.52"}]
["B10","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=C(C=C(C=C4)Cl)Cl",{"v":4.5045,"d":"4.50"}]
["B11","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=C(C=CC(=C4)Cl)Cl",{"v":4.4552,"d":"4.46"}]
["B12","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC(=C(C=C4)Cl)Cl",{"v":4.4412,"d":"4.44"}]
["B13","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=CC=C4Br",{"v":4.443,"d":"4.44"}]
["B14","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=C(C=C4)Br",{"v":4.147,"d":"4.15"}]
["B15","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=C(C=C(C=C4)Br)Br",{"v":4.4447,"d":"4.44"}]
["B16","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC=CC=C4[N+](=O)[O-]",{"v":4.3204,"d":"4.32"}]
["B17","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=CC(=CC=C4)[N+](=O)[O-]",{"v":4.4167,"d":"4.42"}]
["B18","C1COC2=C(O1)C=CC(=C2)C3=NN(C(=S)O3)CNC4=C(C=C(C=C4)[N+](=O)[O-])Cl",{"v":5.0625,"d":"5.06"}]
["B19","CC1=CC=CC=C1NCN2C(=S)OC(=N2)C3=CC4=C(C=C3)OCCO4",{"v":4.0791,"d":"4.08"}]
["B20","CC1=CC=C(C=C1)NCN2C(=S)OC(=N2)C3=CC4=C(C=C3)OCCO4",{"v":4.5991,"d":"4.60"}]
["B21","COC1=CC=C(C=C1)NCN2C(=S)OC(=N2)C3=CC4=C(C=C3)OCCO4",{"v":4.4983,"d":"4.50"}]
["B22","CCOC1=CC=CC=C1NCN2C(=S)OC(=N2)C3=CC4=C(C=C3)OCCO4",{"v":4.6498,"d":"4.65"}]
["B23","C1CCC(CC1)NCN2C(=S)OC(=N2)C3=CC4=C(C=C3)OCCO4",{"v":4.025,"d":"4.03"}]
["B24","CC1CCC2(C(C1(C)CC3=CC(=O)C=C(C3=O)NCC4=CC(=C(C=C4)O)OC)CCC=C2C)C",{"v":4.0223,"d":"4.02"}]
["C1","C1=CC=C(C(=C1)C(=O)NC2=CC(=O)C3C(C2O)O3)O",{"v":4.2441,"d":"4.24"}]
["C2","CC1=C(C2=C(CCC(O2)(C)C(=O)NC3=CC=CC=C3NC(=O)CCCCC4CCSS4)C(=C1O)C)C",{"v":4.2757,"d":"4.28"}]
["C3","CC1=C(C2=C(CCC(O2)(C)C(=O)NC3=CC=C(C=C3)N)C(=C1O)C)C",{"v":4.4685,"d":"4.47"}]
["C4","CC1=C(C2=C(CCC(O2)(C)C(=O)NC3=CC=CC=C3NC(=O)CCCCC(CCS)S)C(=C1O)C)C",{"v":4.1805,"d":"4.18"}]
["C5","CC1=C(C2=C(CCC(O2)(C)C(=O)NC3=CC=C(C=C3)OC4=CC=C(C=C4)NC(=O)CCCCC5CCSS5)C(=C1O)C)C",{"v":4.2596,"d":"4.26"}]
["C6","CC1=C(C2=C(CCC(O2)(C)C(=O)NC3=CC=C(C=C3)NC(=O)CCCCC4CCSS4)C(=C1O)C)C",{"v":4.4815,"d":"4.48"}]
["C7","CC(=CCCC(=CCCC(=CCOC1=C(C=C(C=C1)NC(=O)C2CCCC2)CC=C)C)C)C",{"v":3.3359,"d":"3.34"}]
["C8","CC(=CCCC(=CCCC(=CCOC1=C(C=C(C=C1)NC(=O)C2CCCCC2)CC=C)C)C)C",{"v":3.2765,"d":"3.28"}]
["C9","CC(=CCCC(=CCOC1=C(C=C(C=C1)NC(=O)C23CC4CC(C2)CC(C4)C3)CC=C)C)C",{"v":3.9179,"d":"3.92"}]
["C10","CC(=CCCC(=CCCC(=CCOC1=C(C=C(C=C1)NC(=O)C2CCC2)CC=C)C)C)C",{"v":3.8554,"d":"3.86"}]
["C11","CCOC(=O)C1=CC(=CC=C1)NC(=O)C2=CC=C(C=C2)C=CC3=CC(=C(C=C3)O)O",{"v":3.8975,"d":"3.90"}]
["C12","C1=CC=C(C=C1)NC(=O)C2=CC=C(C=C2)C=CC3=CC(=C(C=C3)O)O",{"v":3.699,"d":"3.70"}]
["C13","C1CCC(CC1)NC(=O)C2=CC=C(C=C2)C=CC3=CC(=C(C=C3)O)O",{"v":3.893,"d":"3.89"}]
["C14","COC1=C(C=C2CCC(OC2=C1)C(=O)NC3=CC=CC=C3)O",{"v":4.6038,"d":"4.60"}]
["C15","COC1=C(C=C2CCC(OC2=C1)C(=O)NC3=CC=C(C=C3)[N+](=O)[O-])O",{"v":4.3969,"d":"4.40"}]
["C16","CCN1CCC2=C(C1)C(=NN2C(=O)NC3=CC=C(C=C3)Br)C(C)(C)C",{"v":4.0915,"d":"4.09"}]
["C17","CCN1CCC2=C(C1)C(=NN2C(=O)NC3=C(C=C(C=C3)C)C)C(C)(C)C",{"v":3.8729,"d":"3.87"}]
["C18","CCN1CCC2=C(C1)C(=NN2C(=O)NC3=C(C=CC=C3C)C)C(C)(C)C",{"v":3.9914,"d":"3.99"}]
["C19","C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=CC(=C(C(=C3)F)O)F",{"v":4.3036,"d":"4.30"}]
["C20","COC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=CC(=C(C(=C3)F)O)F",{"v":4.2449,"d":"4.24"}]