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["Table S3 Instrumental variables (IVs) used in MR analysis of the association between 196 bacterial traits and PE among European populations."]
[{"$nulls":6},"Gut microbiota",{"$nulls":5},"Pulmonary embolism (PE)"]
["Gut microbiota","SNP","Chr","Pos","R2","F","Effect allele","Other allele","beta","se","P-value","Samplesize","Effect allele","Other allele","beta","se","P-value","Samplesize"]
["class.Actinobacteria.id.419","rs10841473",12,20378911,1.371189670979225E-3,22.393437994876468,"G","C",-0.058376469,0.012335331,{"v":2.59e-06,"d":"2.59E-06"},16311,"G","C",{"v":9.93001e-05,"d":"9.93E-05"},1.49269E-4,0.51,463010]
["class.Actinobacteria.id.419","rs11655079",17,75348675,1.2462666024632355E-3,20.348228804346117,"T","C",-0.056067443,0.01242856,{"v":5.93E-6,"d":"5.93E-06"},16309,"T","C",{"v":-4.51887e-05,"d":"-4.52E-05"},0.00014535,0.760001,463010]
["class.Actinobacteria.id.419","rs11745923",5,475408,1.4576828296011593E-3,23.809513670052898,"G","T",0.056375863,0.011552908,{"v":1.58e-06,"d":"1.58E-06"},16312,"G","T",{"v":7.00889e-05,"d":"7.01E-05"},0.000133537,0.6,463010]
["class.Actinobacteria.id.419","rs12049045",1,114665485,1.2207233851226763E-3,19.933110502093868,"A","G",0.05104521,0.01143249,{"v":8.63e-06,"d":"8.63E-06"},16311,"A","G",-1.82967E-4,0.000135903,0.18,463010]
["class.Actinobacteria.id.419","rs1376754",2,161611969,1.2645567932842835E-3,20.48643517611184,"G","A",0.050924155,0.011250292,{"v":6.71e-06,"d":"6.71E-06"},16182,"G","A",{"v":5.91774E-5,"d":"5.92E-05"},0.000132858,0.66,463010]
["class.Actinobacteria.id.419","rs182549",2,136616754,5.2064402299783225E-3,85.36670322916939,"C","T",0.111489458,0.012065989,3.79E-20,16313,"C","T",-0.000264001,1.48028E-4,0.0749998,463010]
["class.Actinobacteria.id.419","rs4945008",11,71221248,1.2148587378950201E-3,19.839663262076503,"A","G",0.054074066,0.012139345,{"v":5.39e-06,"d":"5.39E-06"},16313,"A","G",{"v":-3.4742E-5,"d":"-3.47E-05"},1.5756E-4,0.83,463010]
["class.Actinobacteria.id.419","rs6660520",1,207003553,1.7130443135695212E-3,27.980832983896615,"A","G",0.071148271,0.013449539,{"v":1.11E-7,"d":"1.11E-07"},16308,"A","G",0.000119488,0.000165788,0.47,463010]
["class.Actinobacteria.id.419","rs8047955",16,81776768,1.4892505462844653E-3,24.316954945057823,"A","G",0.05758155,0.011676216,{"v":8.34e-07,"d":"8.34E-07"},16306,"A","G",0.000165951,1.37243E-4,0.23,463010]
["class.Actinobacteria.id.419","rs857444",6,14617591,0.00119402124914562,19.497767322058493,"C","T",0.050955263,0.011539048,{"v":8.92e-06,"d":"8.92E-06"},16312,"C","T",{"v":8.61124e-05,"d":"8.61E-05"},0.000137779,0.53,463010]
["class.Actinobacteria.id.419","rs961091",7,95654718,1.2145633322772002E-3,19.832401093267755,"G","A",0.050125533,0.01125498,{"v":8.68e-06,"d":"8.68E-06"},16311,"G","A",-0.000155519,0.000133768,0.24,463010]
["class.Alphaproteobacteria.id.2379","rs10803434",1,14238305,0.002370081838293039,21.649867750721896,"A","T",-0.069274224,0.01488663,{"v":3.55e-06,"d":"3.55E-06"},9115,"A","T",{"v":1.6022E-5,"d":"1.60E-05"},0.000132618,0.9,463010]
["class.Alphaproteobacteria.id.2379","rs12977163",19,28641647,2.2039467652961034E-3,20.128929962222504,"G","C",0.069023356,0.015382895,{"v":7.14e-06,"d":"7.14E-06"},9115,"G","C",-1.0131E-4,0.00013524,0.450001,463010]
["class.Alphaproteobacteria.id.2379","rs34569731",2,75630344,2.1924711730039624E-3,20.02389160469977,"A","G",0.070514454,0.015756373,{"v":7.38e-06,"d":"7.38E-06"},9115,"A","G",0.000189117,0.000151341,0.21,463010]
["class.Alphaproteobacteria.id.2379","rs55876211",3,84502332,0.00200405029491154,19.25141097315515,"C","T",-0.080810954,0.01841593,{"v":7.54e-06,"d":"7.54E-06"},9589,"C","T",-0.00014701,1.63399E-4,0.37,463010]
["class.Alphaproteobacteria.id.2379","rs62285697",3,176407911,2.1688773835624314E-3,19.807940590766698,"C","T",0.080525582,0.018091166,{"v":9.76e-06,"d":"9.76E-06"},9115,"C","T",-1.21348E-4,1.58701E-4,0.44,463010]
["class.Alphaproteobacteria.id.2379","rs9813022",3,13726736,2.4790173440615354E-3,23.83534357702329,"A","G",-0.075127704,0.015386652,{"v":1.05e-06,"d":"1.05E-06"},9593,"A","G",{"v":-9.31893e-05,"d":"-9.32E-05"},0.000143627,0.52,463010]
["class.Bacilli.id.1673","rs11730038",4,98049499,1.3799435508358578E-3,24.009651159047774,"G","A",-0.063074683,0.012871737,{"v":1.96e-06,"d":"1.96E-06"},17377,"G","A",-0.000123078,1.54592E-4,0.43,463010]
["class.Bacilli.id.1673","rs12797734",11,8332350,1.2033178075783746E-3,20.36057118595506,"T","C",0.057215761,0.012679292,{"v":7.21e-06,"d":"7.21E-06"},16902,"T","C",-0.000165698,0.000152059,0.28,463010]
["class.Bacilli.id.1673","rs1595463",2,231723657,1.1106307661042868E-3,19.2975400181603,"C","A",0.04768644,0.010854727,{"v":7.97e-06,"d":"7.97E-06"},17358,"C","A",{"v":7.35241e-05,"d":"7.35E-05"},0.000132496,0.58,463010]
["class.Bacilli.id.1673","rs1962325",3,4800550,1.3413043376141456E-3,23.308258943779407,"C","G",0.055421868,0.011478925,{"v":1.38e-06,"d":"1.38E-06"},17356,"C","G",{"v":-5.79843E-5,"d":"-5.80E-05"},1.42349E-4,0.68,463010]
["class.Bacilli.id.1673","rs28564647",9,101101172,1.1418779932062344E-3,19.852522388444466,"T","G",-0.061303431,0.013757893,{"v":7.81e-06,"d":"7.81E-06"},17368,"T","G",0.000149045,0.000165164,0.37,463010]
["class.Bacilli.id.1673","rs2952251",8,10143164,1.3438988567257108E-3,23.358788203806483,"A","G",-0.059886787,0.012390272,{"v":1.08E-6,"d":"1.08E-06"},17360,"A","G",-0.000240563,1.49753E-4,0.11,463010]
["class.Bacilli.id.1673","rs35344081",16,991253,1.3663680737681042E-3,23.76902341223463,"G","A",0.061952894,0.012706646,{"v":1.01e-06,"d":"1.01E-06"},17374,"G","A",1.98128E-4,0.000154882,0.2,463010]
["class.Bacilli.id.1673","rs4028634",17,40835649,0.001291106736284734,22.461980357096593,"T","C",0.052061417,0.010984163,{"v":2.21E-6,"d":"2.21E-06"},17377,"T","C",{"v":-4.18766e-05,"d":"-4.19E-05"},0.000134984,0.760001,463010]
["class.Bacilli.id.1673","rs4459992",4,7431487,1.2199503079841413E-3,21.2042054235417,"T","C",0.053585401,0.011636181,{"v":4.3e-06,"d":"4.30E-06"},17362,"T","C",-0.000162327,0.000142203,0.25,463010]
["class.Bacteroidia.id.912","rs11146701",10,39062269,1.1066827972553838E-3,20.183884357999368,"A","G",0.047359582,0.010540996,{"v":7.08E-6,"d":"7.08E-06"},18220,"A","G",{"v":3.11793e-05,"d":"3.12E-05"},0.00013314,0.81,463010]
["class.Bacteroidia.id.912","rs17343978",22,27433885,1.1477349568295488E-3,21.06445363838658,"A","C",-0.055205684,0.012027767,{"v":8.36e-06,"d":"8.36E-06"},18334,"A","C",{"v":-9.76057e-05,"d":"-9.76E-05"},1.50896E-4,0.52,463010]
["class.Bacteroidia.id.912","rs2032750",2,53831026,1.2674614356387223E-3,22.65416737108619,"T","C",-0.050839276,0.010680731,{"v":1.92e-06,"d":"1.92E-06"},17853,"T","C",{"v":-4.99256E-6,"d":"-4.99E-06"},0.000131785,0.97,463010]
["class.Bacteroidia.id.912","rs4916508",3,195936789,1.070742862810785E-3,19.639179243425563,"G","A",-0.046672941,0.010531247,{"v":8.47e-06,"d":"8.47E-06"},18324,"G","A",-0.000194326,0.000131899,0.14,463010]
["class.Bacteroidia.id.912","rs7546249",1,176792690,0.00125014895026578,22.9451652816125,"T","A",-0.056711256,0.01183859,{"v":1.55E-6,"d":"1.55E-06"},18333,"T","A",-1.24556E-4,0.000147168,0.4,463010]
["class.Bacteroidia.id.912","rs929878",16,74290641,1.1099432809603784E-3,20.37008987095048,"C","T",-0.054853206,0.012152954,{"v":4.73e-06,"d":"4.73E-06"},18334,"C","T",-1.15908E-4,0.000148976,0.44,463010]
["class.Betaproteobacteria.id.2867","rs11128180",3,70592215,1.2347451092058908E-3,21.200821488415787,"A","G",0.059294412,0.012876923,{"v":3.67E-6,"d":"3.67E-06"},17151,"A","G",{"v":2.75338e-05,"d":"2.75E-05"},1.54353E-4,0.86,463010]
["class.Betaproteobacteria.id.2867","rs12467854",2,239888758,1.3885984004518934E-3,23.689056936668926,"G","C",0.06413625,0.013176625,{"v":1.1e-06,"d":"1.10E-06"},17038,"G","C",{"v":-3.45421e-05,"d":"-3.45E-05"},1.60493E-4,0.83,463010]
["class.Betaproteobacteria.id.2867","rs1928341",1,153240013,1.3195985813222154E-3,22.658376433910604,"A","G",0.052558097,0.011040784,{"v":2.02e-06,"d":"2.02E-06"},17150,"A","G",{"v":9.84087e-06,"d":"9.84E-06"},1.32865E-4,0.94,463010]
["class.Betaproteobacteria.id.2867","rs2321387",13,58689340,1.1899276402354564E-3,20.427997085484037,"G","A",-0.049459619,0.010942399,{"v":5.8e-06,"d":"5.80E-06"},17149,"G","A",-1.72106E-4,0.000132512,0.19,463010]
["class.Betaproteobacteria.id.2867","rs2367850",3,193456274,1.4397018668776066E-3,24.099312530099244,"G","C",0.064005972,0.013037436,{"v":9.12e-07,"d":"9.12E-07"},16717,"G","C",{"v":-3.83612e-06,"d":"-3.84E-06"},0.000169244,0.98,463010]
["class.Betaproteobacteria.id.2867","rs2613606",7,111285025,1.2885851136613885E-3,22.1200066999585,"C","T",-0.051310589,0.010909103,{"v":2.2e-06,"d":"2.20E-06"},17146,"C","T",-0.000315553,0.000132363,0.017,463010]
["class.Betaproteobacteria.id.2867","rs320161",9,104899117,1.2057111338210757E-3,20.561669175829625,"A","G",0.057228557,0.012619964,{"v":7.33e-06,"d":"7.33E-06"},17035,"A","G",{"v":1.47565E-5,"d":"1.48E-05"},0.000149248,0.92,463010]
["class.Betaproteobacteria.id.2867","rs56386628",8,112732674,1.2249863265197671E-3,21.02814976411446,"C","T",-0.062225169,0.013568762,{"v":5.87e-06,"d":"5.87E-06"},17147,"C","T",{"v":9.96122e-05,"d":"9.96E-05"},0.000164355,0.54,463010]
["class.Betaproteobacteria.id.2867","rs9964679",18,26569901,1.2356165028450162E-3,21.215802002364395,"A","G",0.052911029,0.011486591,{"v":4.85e-06,"d":"4.85E-06"},17151,"A","G",-2.09108E-4,1.44585E-4,0.15,463010]
["class.Clostridia.id.1859","rs10774377",12,5942519,1.1655923303597966E-3,21.387905809808725,"A","G",0.052659008,0.011385834,{"v":3.24e-06,"d":"3.24E-06"},18330,"A","G",-1.06069E-4,0.000143107,0.46,463010]
["class.Clostridia.id.1859","rs112334273",21,40703251,1.3876608089485535E-3,25.31136522454098,"G","A",0.064100812,0.012740366,{"v":3.81e-07,"d":"3.81E-07"},18217,"G","A",{"v":2.98264E-5,"d":"2.98E-05"},1.60099E-4,0.85,463010]
["class.Clostridia.id.1859","rs13105690",4,7420184,1.0917177251230604E-3,20.041799631207436,"T","C",-0.052909681,0.011817976,{"v":8.78e-06,"d":"8.78E-06"},18340,"T","C",-1.45122E-4,1.48329E-4,0.33,463010]
["class.Clostridia.id.1859","rs13179700",5,149077788,1.1890255693714725E-3,21.827926803090563,"T","C",0.051193667,0.010956865,{"v":3.37e-06,"d":"3.37E-06"},18338,"T","C",{"v":-8.18859e-06,"d":"-8.19E-06"},1.38343E-4,0.95,463010]
["class.Clostridia.id.1859","rs1842454",5,105060362,1.0058683103406204E-3,18.464185614211882,"G","A",-0.054720208,0.012733828,{"v":8.72e-06,"d":"8.72E-06"},18340,"G","A",1.66639E-4,0.000156461,0.29,463010]
["class.Clostridia.id.1859","rs6934062",6,163743050,1.1407813334997471E-3,20.394197592229904,"G","C",0.052440576,0.01161154,{"v":6.53e-06,"d":"6.53E-06"},17859,"G","C",-0.000188151,0.000144307,0.19,463010]
["class.Clostridia.id.1859","rs72915163",18,48792829,0.001266475833114484,23.224918681728234,"T","C",-0.058102511,0.012055746,{"v":1.34e-06,"d":"1.34E-06"},18317,"T","C",2.56369E-4,0.000151393,0.0899995,463010]
["class.Coriobacteriia.id.809","rs11073596",15,86433579,1.134777379060325E-3,19.909566493716163,"T","G",0.051021228,0.011433922,{"v":8.14E-6,"d":"8.14E-06"},17527,"T","G",{"v":-1.22782E-5,"d":"-1.23E-05"},0.000143403,0.93,463010]
["class.Coriobacteriia.id.809","rs11250875",10,1922731,1.2153436654814562E-3,21.523156787298603,"T","C",0.060749978,0.013093887,{"v":4.83e-06,"d":"4.83E-06"},17690,"T","C",0.000241435,0.000162937,0.14,463010]
["class.Coriobacteriia.id.809","rs13307134",7,105084680,1.1438841987223393E-3,20.06952779833333,"C","T",0.056568602,0.012626474,{"v":7.8e-06,"d":"7.80E-06"},17527,"C","T",{"v":-8.61174e-05,"d":"-8.61E-05"},1.54551E-4,0.58,463010]
["class.Coriobacteriia.id.809","rs1397793",5,90471451,1.121662389908922E-3,19.679206809295085,"G","A",-0.049885455,0.011244635,{"v":9.77e-06,"d":"9.77E-06"},17527,"G","A",{"v":6.68435e-06,"d":"6.68E-06"},1.43769E-4,0.96,463010]
["class.Coriobacteriia.id.809","rs1816223",12,11494021,1.1662289951448824E-3,20.650008646966473,"A","G",-0.058626474,0.012900576,{"v":4.84e-06,"d":"4.84E-06"},17688,"A","G",-0.000354293,1.62733E-4,0.0290001,463010]
["class.Coriobacteriia.id.809","rs240104",1,176571431,0.001285801521275367,22.627055638977154,"T","C",-0.060342897,0.012684911,{"v":1.52e-06,"d":"1.52E-06"},17577,"T","C",{"v":4.86297E-5,"d":"4.86E-05"},0.000158705,0.760001,463010]
["class.Coriobacteriia.id.809","rs62448869",7,24464799,1.1336152066599658E-3,19.88915314316658,"T","A",-0.048605943,0.010898242,{"v":7.87e-06,"d":"7.87E-06"},17527,"T","A",0.000124441,0.000132706,0.35,463010]
["class.Deltaproteobacteria.id.3087","rs1035691",11,10658735,1.3555108669870018E-3,20.585581788542488,"A","G",-0.055175977,0.012160175,{"v":9.65e-06,"d":"9.65E-06"},15168,"A","G",0.000161494,1.36885E-4,0.24,463010]
["class.Deltaproteobacteria.id.3087","rs11599763",10,11855599,1.4147932276439652E-3,21.487153970366997,"T","C",-0.054421883,0.011739659,{"v":3.94e-06,"d":"3.94E-06"},15168,"T","C",1.88183E-4,0.000134968,0.16,463010]
["class.Deltaproteobacteria.id.3087","rs2838334",21,45064961,1.3483946538959174E-3,20.47736489032948,"G","A",0.056172159,0.012412391,{"v":5.45e-06,"d":"5.45E-06"},15168,"G","A",{"v":9.13004e-05,"d":"9.13E-05"},1.41085E-4,0.52,463010]
["class.Deltaproteobacteria.id.3087","rs3935584",2,233929283,1.3489037039239539E-3,20.482404557675956,"C","T",-0.052348451,0.011566041,{"v":7.5e-06,"d":"7.50E-06"},15166,"C","T",-0.000123952,0.000132494,0.35,463010]
["class.Deltaproteobacteria.id.3087","rs62020470",15,96161065,1.3483980701155251E-3,20.477416840721038,"A","G",-0.058541133,0.012935848,{"v":4.85e-06,"d":"4.85E-06"},15168,"A","G",-1.13937E-4,1.4579E-4,0.43,463010]
["class.Deltaproteobacteria.id.3087","rs9928243",16,71541641,1.377586312920946E-3,20.91991542460254,"C","A",-0.053845737,0.011771796,{"v":5.02e-06,"d":"5.02E-06"},15167,"C","A",1.31944E-4,1.33583E-4,0.32,463010]
["class.Erysipelotrichia.id.2147","rs1074800",5,3002546,1.1487695394769397E-3,20.456663790918654,"A","G",0.049243827,0.010887044,{"v":6.15e-06,"d":"6.15E-06"},17789,"A","G",{"v":-9.71002e-05,"d":"-9.71E-05"},1.37997E-4,0.48,463010]
["class.Erysipelotrichia.id.2147","rs10781552",10,133897233,1.270681589885386E-3,22.630369433102313,"C","T",-0.055221236,0.011607425,{"v":2.33e-06,"d":"2.33E-06"},17789,"C","T",{"v":9.4191e-05,"d":"9.42E-05"},0.000142202,0.51,463010]
["class.Erysipelotrichia.id.2147","rs1884466",1,64139196,1.0842283811211277E-3,19.757631005828124,"C","T",-0.047536345,0.01069386,{"v":9.53e-06,"d":"9.53E-06"},18205,"C","T",{"v":2.04122e-05,"d":"2.04E-05"},1.35563E-4,0.88,463010]
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