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["Additional file 7: Table S5 The 188 KEGG pathway analysis of the DEMs target genes."]
["Pathway","ko_id","count","P-Value","Corrected P-Value"]
["Jak-STAT signaling pathway","ko04630",20,{"v":1.45989848210348e-06,"d":"1.46E-06"},0.000274460914635455]
["Tight junction","ko04530",14,0.00056880980161389,0.106936242703411]
["Folate biosynthesis","ko00790",6,0.00259287073412784,0.487459698016034]
["Biotin metabolism","ko00780",1,0.103054567022539,1]
["African trypanosomiasis","ko05143",3,0.0171696058682398,1]
["NOD-like receptor signaling pathway","ko04621",3,0.0277719547484472,1]
["RIG-I-like receptor signaling pathway","ko04622",4,0.0141343363236119,1]
["Bladder cancer","ko05219",3,0.041090594881027,1]
["Drug metabolism - cytochrome P450","ko00982",4,0.0204307345744428,1]
["Collecting duct acid secretion","ko04966",1,0.278434324062695,1]
["Toxoplasmosis","ko05145",1,0.278434324062695,1]
["Phenylalanine, tyrosine and tryptophan biosynthesis","ko00400",1,0.278434324062695,1]
["Cholinergic synapse","ko04725",3,0.057024454928794,1]
["Non-homologous end-joining","ko03450",2,0.157249124406675,1]
["Asthma","ko05310",2,0.157249124406675,1]
["ECM-receptor interaction","ko04512",2,0.157249124406675,1]
["Ras signaling pathway","ko04014",5,0.0314551507491818,1]
["Neurotrophin signaling pathway","ko04722",3,0.0960216342397029,1]
["Rap1 signaling pathway","ko04015",4,0.0607226333779137,1]
["Bacterial invasion of epithelial cells","ko05100",5,0.0391820149504882,1]
["Endocrine and other factor-regulated calcium reabsorption","ko04961",1,0.35282805567172,1]
["Glyoxylate and dicarboxylate metabolism","ko00630",2,0.195968634248564,1]
["Synaptic vesicle cycle","ko04721",3,0.11862892296083,1]
["Salmonella infection","ko05132",7,0.0295785385217722,1]
["mRNA surveillance pathway","ko03015",10,0.0104101685249443,1]
["Non-alcoholic fatty liver disease (NAFLD)","ko04932",3,0.142969034168613,1]
["Amoebiasis","ko05146",9,0.0182513992237897,1]
["Progesterone-mediated oocyte maturation","ko04914",4,0.106666277547918,1]
["Thyroid hormone signaling pathway","ko04919",8,0.0272561666638367,1]
["Pancreatic secretion","ko04972",4,0.124662080907243,1]
["ABC transporters","ko02010",5,0.0937284275390239,1]
["RNA polymerase","ko03020",1,0.419561661207053,1]
["Sulfur metabolism","ko00920",1,0.419561661207053,1]
["Pyruvate metabolism","ko00620",2,0.275732230413587,1]
["Other glycan degradation","ko00511",2,0.275732230413587,1]
["Calcium signaling pathway","ko04020",1,0.419561661207053,1]
["Adherens junction","ko04520",2,0.275732230413587,1]
["Phenylalanine metabolism","ko00360",1,0.419561661207053,1]
["Fc gamma R-mediated phagocytosis","ko04666",2,0.275732230413587,1]
["Mismatch repair","ko03430",1,0.419561661207053,1]
["Hepatitis B","ko05161",1,0.419561661207053,1]
["Type I diabetes mellitus","ko04940",1,0.419561661207053,1]
["Circadian entrainment","ko04713",2,0.275732230413587,1]
["AMPK signaling pathway","ko04152",3,0.195790954840526,1]
["Regulation of actin cytoskeleton","ko04810",8,0.0546929464866484,1]
["Small cell lung cancer","ko05222",9,0.0477565352545446,1]
["Type II diabetes mellitus","ko04930",2,0.315667918452226,1]
["Glycosylphosphatidylinositol(GPI)-anchor biosynthesis","ko00563",4,0.185262061447114,1]
["beta-Alanine metabolism","ko00410",2,0.315667918452226,1]
["Aldosterone-regulated sodium reabsorption","ko04960",2,0.315667918452226,1]
["Inflammatory mediator regulation of TRP channels","ko04750",4,0.185262061447114,1]
["Natural killer cell mediated cytotoxicity","ko04650",6,0.117751465435248,1]
["Morphine addiction","ko05032",6,0.117751465435248,1]
["Glycosaminoglycan degradation","ko00531",1,0.479422863976178,1]
["PI3K-Akt signaling pathway","ko04151",2,0.355075717550515,1]
["ErbB signaling pathway","ko04012",1,0.479422863976178,1]
["Bile secretion","ko04976",8,0.11545305274489,1]
["Dorso-ventral axis formation","ko04320",1,0.479422863976178,1]
["Huntington's disease","ko05016",16,0.0352669472515047,1]
["Prostate cancer","ko05215",3,0.281579244881395,1]
["Cell adhesion molecules (CAMs)","ko04514",7,0.135683193712836,1]
["Central carbon metabolism in cancer","ko05230",6,0.160369726843749,1]
["HTLV-I infection","ko05166",11,0.0863759612115967,1]
["Viral carcinogenesis","ko05203",12,0.0873150892467337,1]
["Aminoacyl-tRNA biosynthesis","ko00970",7,0.176018436011891,1]
["Amyotrophic lateral sclerosis (ALS)","ko05014",2,0.393640569074516,1]
["Alzheimer's disease","ko05010",4,0.277002232506916,1]
["Dilated cardiomyopathy","ko05414",12,0.101554379676549,1]
["Basal cell carcinoma","ko05217",8,0.174479891988307,1]
["Nitrogen metabolism","ko00910",3,0.34050090220625,1]
["Retinol metabolism","ko00830",3,0.34050090220625,1]
["Ubiquitin mediated proteolysis","ko04120",8,0.201255511479276,1]
["cGMP-PKG signaling pathway","ko04022",1,0.533118487237765,1]
["B cell receptor signaling pathway","ko04662",1,0.533118487237765,1]
["Alcoholism","ko05034",4,0.32537368137556,1]
["Influenza A","ko05164",5,0.290210782873375,1]
["Glycosphingolipid biosynthesis - globo series","ko00603",1,0.533118487237765,1]
["Pertussis","ko05133",1,0.533118487237765,1]
["Hedgehog signaling pathway","ko04340",1,0.533118487237765,1]
["Fatty acid metabolism","ko01212",3,0.369905047313124,1]
["p53 signaling pathway","ko04115",3,0.369905047313124,1]
["Proteoglycans in cancer","ko05205",10,0.191580177196739,1]
["Transcriptional misregulation in cancer","ko05202",12,0.171307210544728,1]
["Insulin signaling pathway","ko04910",6,0.27943861687661,1]
["Hippo signaling pathway","ko04390",5,0.311152888684644,1]
["Wnt signaling pathway","ko04310",5,0.311152888684644,1]
["Phosphatidylinositol signaling system","ko04070",4,0.349786730096736,1]
["Biosynthesis of amino acids","ko01230",7,0.269064955808431,1]
["Chronic myeloid leukemia","ko05220",3,0.399059202976168,1]
["Nicotine addiction","ko05033",3,0.399059202976168,1]
["Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate","ko00532",2,0.46732190944252,1]
["SNARE interactions in vesicular transport","ko04130",2,0.46732190944252,1]
["Fanconi anemia pathway","ko03460",5,0.353549739406012,1]
["Notch signaling pathway","ko04330",3,0.427827354495535,1]
["Purine metabolism","ko00230",4,0.398563236514072,1]
["Primary immunodeficiency","ko05340",4,0.398563236514072,1]
["MicroRNAs in cancer","ko05206",9,0.292506973535659,1]
["Axon guidance","ko04360",10,0.280502473064719,1]
["mTOR signaling pathway","ko04150",1,0.581282751950511,1]
["Arachidonic acid metabolism","ko00590",2,0.502117163289974,1]
["Non-small cell lung cancer","ko05223",3,0.456091241436477,1]
["Phototransduction","ko04744",2,0.502117163289974,1]
["Glutamatergic synapse","ko04724",2,0.502117163289974,1]
["Tryptophan metabolism","ko00380",1,0.581282751950511,1]
["Dopaminergic synapse","ko04728",2,0.502117163289974,1]
["Insulin secretion","ko04911",2,0.502117163289974,1]
["Sphingolipid metabolism","ko00600",2,0.502117163289974,1]
["Protein processing in endoplasmic reticulum","ko04141",13,0.295289455287012,1]
["Carbon metabolism","ko01200",3,0.483749473657264,1]
["Ovarian steroidogenesis","ko04913",2,0.535409173907416,1]
["Porphyrin and chlorophyll metabolism","ko00860",2,0.535409173907416,1]
["Protein digestion and absorption","ko04974",8,0.434833802405804,1]
["Fat digestion and absorption","ko04975",4,0.493540143058013,1]
["Endocytosis","ko04144",11,0.416242794685633,1]
["Viral myocarditis","ko05416",8,0.451046648740482,1]
["Glycerolipid metabolism","ko00561",1,0.624484724544694,1]
["Base excision repair","ko03410",2,0.567137915035669,1]
["Arrhythmogenic right ventricular cardiomyopathy (ARVC)","ko05412",2,0.567137915035669,1]
["TGF-beta signaling pathway","ko04350",2,0.567137915035669,1]
["FoxO signaling pathway","ko04068",1,0.624484724544694,1]
["Gap junction","ko04540",2,0.567137915035669,1]
["Ribosome biogenesis in eukaryotes","ko03008",5,0.500591042720834,1]
["Valine, leucine and isoleucine degradation","ko00280",1,0.624484724544694,1]
["Lysosome","ko04142",9,0.473723699345603,1]
["Other types of O-glycan biosynthesis","ko00514",2,0.59727164467204,1]
["Sphingolipid signaling pathway","ko04071",2,0.59727164467204,1]
["N-Glycan biosynthesis","ko00510",2,0.625801727168231,1]
["Oocyte meiosis","ko04114",1,0.663235001670367,1]
["Oxytocin signaling pathway","ko04921",2,0.625801727168231,1]
["cAMP signaling pathway","ko04024",1,0.663235001670367,1]
["GABAergic synapse","ko04727",1,0.663235001670367,1]
["Circadian rhythm","ko04710",1,0.663235001670367,1]
["Protein export","ko03060",1,0.663235001670367,1]
["Neuroactive ligand-receptor interaction","ko04080",11,0.601690424625995,1]
["Lysine degradation","ko00310",4,0.622217218535476,1]
["MAPK signaling pathway","ko04010",3,0.633155102644303,1]
["Glycerophospholipid metabolism","ko00564",3,0.633155102644303,1]
["Chemokine signaling pathway","ko04062",2,0.652738219784554,1]
["Pantothenate and CoA biosynthesis","ko00770",1,0.69799170999218,1]
["Acute myeloid leukemia","ko05221",1,0.69799170999218,1]
["Tuberculosis","ko05152",4,0.695567087322657,1]
["Choline metabolism in cancer","ko05231",8,0.722599260149183,1]
["Melanoma","ko05218",2,0.70194219451015,1]
["Systemic lupus erythematosus","ko05322",7,0.742982311563961,1]
["Hepatitis C","ko05160",3,0.714572673692252,1]
["Rheumatoid arthritis","ko05323",4,0.743504593803165,1]
["Alanine, aspartate and glutamate metabolism","ko00250",1,0.729165891123244,1]
["Cytokine-cytokine receptor interaction","ko04060",2,0.724292281153207,1]
["Carbohydrate digestion and absorption","ko04973",1,0.729165891123244,1]
["Salivary secretion","ko04970",2,0.724292281153207,1]
["Autoimmune thyroid disease","ko05320",1,0.729165891123244,1]
["Mineral absorption","ko04978",3,0.749706876406599,1]
["RNA degradation","ko03018",4,0.77213306033147,1]
["Ether lipid metabolism","ko00565",1,0.757126334627312,1]
["Steroid biosynthesis","ko00100",1,0.757126334627312,1]
["Vascular smooth muscle contraction","ko04270",1,0.757126334627312,1]
["RNA transport","ko03013",6,0.828540587469246,1]
["Hematopoietic cell lineage","ko04640",3,0.781289546859019,1]
["Mucin type O-Glycan biosynthesis","ko00512",2,0.782976378125046,1]
["Signaling pathways regulating pluripotency of stem cells","ko04550",3,0.809511850830591,1]
["Glutathione metabolism","ko00480",1,0.782203915586157,1]
["TNF signaling pathway","ko04668",1,0.782203915586157,1]
["Osteoclast differentiation","ko04380",1,0.804695487453561,1]
["Thyroid hormone synthesis","ko04918",1,0.804695487453561,1]
["Glycosphingolipid biosynthesis - lacto and neolacto series","ko00601",1,0.804695487453561,1]
["Phagosome","ko04145",1,0.804695487453561,1]
["Taste transduction","ko04742",5,0.897941985412343,1]
["Spliceosome","ko03040",6,0.932243668579229,1]
["Staphylococcus aureus infection","ko05150",1,0.824867375731124,1]
["Pathways in cancer","ko05200",3,0.893466600138831,1]
["Vitamin digestion and absorption","ko04977",1,0.842958513345105,1]
["Nicotinate and nicotinamide metabolism","ko00760",1,0.873733899408249,1]
["Chemical carcinogenesis","ko05204",3,0.942617460638712,1]
["Parkinson's disease","ko05012",1,0.873733899408249,1]
["Maturity onset diabetes of the young","ko04950",1,0.886782961105089,1]
["Ribosome","ko03010",6,0.988143704040706,1]
["Nucleotide excision repair","ko03420",3,0.961617984462152,1]
["Peroxisome","ko04146",3,0.964628479618784,1]
["PPAR signaling pathway","ko03320",1,0.908979439919006,1]
["Gastric acid secretion","ko04971",1,0.908979439919006,1]
["Herpes simplex infection","ko05168",4,0.987852868759848,1]
["Renal cell carcinoma","ko05211",1,0.926829264785925,1]
["Glycosaminoglycan biosynthesis - heparan sulfate / heparin","ko00534",1,0.926829264785925,1]
["Cell cycle","ko04110",1,0.934396773859405,1]
["Epstein-Barr virus infection","ko05169",3,0.987094262520849,1]
["Serotonergic synapse","ko04726",1,0.952723666713938,1]
["Amino sugar and nucleotide sugar metabolism","ko00520",1,0.98232349957489,1]
["Olfactory transduction","ko04740",16,1,1]