positive correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0071294~cellular response to zinc ion 5 0.017712282 2.62E-05 "MT1L, MT1F, MT1G, MT1H, MT1E" 159 19 16792 27.79212181 0.026469208 0.013412737 0.01338654 GOTERM_BP_DIRECT GO:0045926~negative regulation of growth 5 0.017712282 2.62E-05 "MT1L, MT1F, MT1G, MT1H, MT1E" 159 19 16792 27.79212181 0.026469208 0.013412737 0.01338654 GOTERM_BP_DIRECT GO:0006590~thyroid hormone generation 4 0.014169825 1.69E-04 "TPO, FOXE1, CPQ, DIO1" 159 12 16792 35.2033543 0.158879896 0.057668734 0.0575561 GOTERM_BP_DIRECT GO:0071276~cellular response to cadmium ion 4 0.014169825 5.04E-04 "MT1F, MT1G, MT1H, MT1E" 159 17 16792 24.84942656 0.40351518 0.129142787 0.128890555 GOTERM_BP_DIRECT GO:0030300~regulation of intestinal cholesterol absorption 3 0.010627369 8.64E-04 "APOA1, APOA4, APOA5" 159 5 16792 63.36603774 0.58714506 0.176855391 0.17650997 GOTERM_BP_DIRECT GO:0034380~high-density lipoprotein particle assembly 3 0.010627369 0.002373422 "APOA1, APOA4, APOA5" 159 8 16792 39.60377358 0.912250811 0.26394187 0.263426359 GOTERM_BP_DIRECT GO:0010898~positive regulation of triglyceride catabolic process 3 0.010627369 0.002373422 "APOA1, APOA4, APOA5" 159 8 16792 39.60377358 0.912250811 0.26394187 0.263426359 GOTERM_BP_DIRECT GO:0031102~neuron projection regeneration 3 0.010627369 0.002373422 "APOA1, APOA4, APOA5" 159 8 16792 39.60377358 0.912250811 0.26394187 0.263426359 GOTERM_BP_DIRECT GO:0001523~retinoid metabolic process 5 0.017712282 0.002596281 "RDH12, ALDH1A1, APOA1, APOA4, LRP2" 159 61 16792 8.656562532 0.930194938 0.26394187 0.263426359 GOTERM_BP_DIRECT GO:0042158~lipoprotein biosynthetic process 3 0.010627369 0.003032724 "APOA1, APOA4, P4HB" 159 9 16792 35.2033543 0.955409221 0.26394187 0.263426359 GOTERM_BP_DIRECT GO:0010873~positive regulation of cholesterol esterification 3 0.010627369 0.003032724 "APOA1, APOA4, APOA5" 159 9 16792 35.2033543 0.955409221 0.26394187 0.263426359 GOTERM_BP_DIRECT GO:0042632~cholesterol homeostasis 5 0.017712282 0.003093069 "APOA1, APOA4, LAMTOR1, LDLRAP1, APOA5" 159 64 16792 8.250786164 0.958089166 0.26394187 0.263426359 GOTERM_BP_DIRECT GO:0045723~positive regulation of fatty acid biosynthetic process 3 0.010627369 0.003767545 "APOA1, APOA4, APOA5" 159 10 16792 31.68301887 0.979042359 0.270858357 0.270329337 GOTERM_BP_DIRECT GO:0051006~positive regulation of lipoprotein lipase activity 3 0.010627369 0.003767545 "APOA1, APOA4, APOA5" 159 10 16792 31.68301887 0.979042359 0.270858357 0.270329337 GOTERM_BP_DIRECT GO:0055114~oxidation-reduction process 14 0.049594389 0.003967652 "HGD, DIO1, ECSIT, SOD3, PDIA5, FA2H, TPO, RDH12, SPR, AIFM2, PRDX1, ALDH1A1, MSRB2, CYB561" 159 592 16792 2.497535271 0.982938943 0.270858357 0.270329337 GOTERM_BP_DIRECT GO:0019430~removal of superoxide radicals 3 0.010627369 0.005457917 "PRDX1, APOA4, SOD3" 159 12 16792 26.40251572 0.99631769 0.331557163 0.33090959 GOTERM_BP_DIRECT GO:0006810~transport 10 0.035424563 0.005736812 "SLC25A15, CACNB4, ABCB6, CLCNKA, ABCB8, SYPL2, LDLRAP1, GRIN2C, SLC4A4, SLC27A4" 159 348 16792 3.034771922 0.997236923 0.331557163 0.33090959 GOTERM_BP_DIRECT GO:0000302~response to reactive oxygen species 4 0.014169825 0.005828153 "PRDX1, P4HB, SOD3, PPARGC1A" 159 39 16792 10.83180132 0.997485014 0.331557163 0.33090959 GOTERM_BP_DIRECT GO:0033700~phospholipid efflux 3 0.010627369 0.007433093 "APOA1, APOA4, APOA5" 159 14 16792 22.63072776 0.999519131 0.400604585 0.399822154 GOTERM_BP_DIRECT GO:0055085~transmembrane transport 8 0.028339651 0.008390296 "SLC5A8, DMTN, ABCB6, BCL2, VDAC3, APOA1, ABCB8, CYB561" 159 244 16792 3.462625013 0.999820961 0.41564612 0.414834311 GOTERM_BP_DIRECT GO:0032469~endoplasmic reticulum calcium ion homeostasis 3 0.010627369 0.008523993 "WFS1, BCL2, TMCO1" 159 15 16792 21.12201258 0.999844051 0.41564612 0.414834311 GOTERM_BP_DIRECT GO:0043691~reverse cholesterol transport 3 0.010627369 0.012193662 "APOA1, APOA4, APOA5" 159 18 16792 17.60167715 0.999996501 0.56755956 0.566451046 GOTERM_BP_DIRECT GO:0071456~cellular response to hypoxia 5 0.017712282 0.012839972 "BCL2, HYOU1, P4HB, PPARGC1A, BMP7" 159 96 16792 5.500524109 0.99999821 0.57165787 0.57054135 GOTERM_BP_DIRECT GO:0042744~hydrogen peroxide catabolic process 3 0.010627369 0.014957734 "TPO, PRDX1, APOA4" 159 20 16792 15.84150943 0.999999801 0.638196659 0.636950181 GOTERM_BP_DIRECT GO:0036498~IRE1-mediated unfolded protein response 4 0.014169825 0.018091955 "WFS1, SRPRB, HYOU1, PDIA5" 159 59 16792 7.160004264 0.999999992 0.710371793 0.708984348 GOTERM_BP_DIRECT GO:1903445~protein transport from ciliary membrane to plasma membrane 2 0.007084913 0.018730506 "RILPL2, RILPL1" 159 2 16792 105.6100629 0.999999996 0.710371793 0.708984348 GOTERM_BP_DIRECT GO:0019518~L-threonine catabolic process to glycine 2 0.007084913 0.018730506 "TDH, GCAT" 159 2 16792 105.6100629 0.999999996 0.710371793 0.708984348 GOTERM_BP_DIRECT GO:0033344~cholesterol efflux 3 0.010627369 0.022905664 "APOA1, APOA4, APOA5" 159 25 16792 12.67320755 1 0.837692856 0.836056738 GOTERM_BP_DIRECT GO:0070328~triglyceride homeostasis 3 0.010627369 0.024663405 "APOA1, APOA4, APOA5" 159 26 16792 12.18577649 1 0.87087332 0.869172396 GOTERM_BP_DIRECT GO:0033077~T cell differentiation in thymus 3 0.010627369 0.026474446 "BCL2, FZD8, RAG2" 159 27 16792 11.73445143 1 0.874510718 0.872802689 GOTERM_BP_DIRECT GO:0001656~metanephros development 3 0.010627369 0.026474446 "BCL2, ID3, BMP7" 159 27 16792 11.73445143 1 0.874510718 0.872802689 GOTERM_BP_DIRECT GO:0019276~UDP-N-acetylgalactosamine metabolic process 2 0.007084913 0.027964609 "CSGALNACT1, B4GALNT2" 159 3 16792 70.4067086 1 0.894867478 0.89311969 GOTERM_BP_DIRECT GO:0006898~receptor-mediated endocytosis 6 0.021254738 0.031375215 "APOA1, HYOU1, LRP2, LDLRAP1, PLA2R1, LRP1B" 159 186 16792 3.406776222 1 0.959458858 0.957584915 GOTERM_BP_DIRECT GO:0007584~response to nutrient 4 0.014169825 0.032600313 "APOA1, TNFRSF11B, AACS, SLC27A4" 159 74 16792 5.708652048 1 0.959458858 0.957584915 GOTERM_BP_DIRECT GO:0007623~circadian rhythm 4 0.014169825 0.033730975 "ID1, ID4, ID3, PPARGC1A" 159 75 16792 5.632536688 1 0.959458858 0.957584915 GOTERM_BP_DIRECT GO:0034976~response to endoplasmic reticulum stress 4 0.014169825 0.033730975 "WFS1, HYOU1, P4HB, PDIA5" 159 75 16792 5.632536688 1 0.959458858 0.957584915 GOTERM_BP_DIRECT GO:0002326~B cell lineage commitment 2 0.007084913 0.03711236 "BCL2, RAG2" 159 4 16792 52.80503145 1 1 0.999022483 GOTERM_BP_DIRECT GO:0002931~response to ischemia 3 0.010627369 0.038397025 "BCL2, HYOU1, PPARGC1A" 159 33 16792 9.600914808 1 1 0.999022483 GOTERM_BP_DIRECT GO:0045927~positive regulation of growth 2 0.007084913 0.046174562 "WFS1, TFCP2L1" 159 5 16792 42.24402516 1 1 0.999022483 GOTERM_BP_DIRECT GO:0006695~cholesterol biosynthetic process 3 0.010627369 0.049597828 "APOA1, APOA4, APOA5" 159 38 16792 8.337636544 1 1 0.999022483 GOTERM_BP_DIRECT GO:0042157~lipoprotein metabolic process 3 0.010627369 0.049597828 "APOA1, APOA4, APOA5" 159 38 16792 8.337636544 1 1 0.999022483 negative correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0007165~signal transduction 31 0.101204662 5.30E-06 "CNTNAP1, SDC4, RASGRF1, ARHGAP19, NOD1, IQGAP3, CORO1C, EPS8, PPP3CB, FGF20, TP53BP2, PTK2B, STAT6, SRGAP2, PLEKHG5, ACTL6A, HMGA2, IL17RD, HPCAL4, TGFBR1, ARHGAP23, INPP4A, AFDN, DLG4, DLC1, RASA1, PPP1R1B, ZNF217, PDE5A, MET, SKAP2" 180 1161 16792 2.490917791 0.005807904 0.00582482 0.00582482 GOTERM_BP_DIRECT GO:0043547~positive regulation of GTPase activity 15 0.048969998 0.002976038 "DOCK9, PLEKHG5, RASGRF1, ARHGAP19, SIPA1L2, ARHGAP23, AFDN, DLG4, RASGEF1B, RASA1, DLC1, FGF20, FYN, SRGAP2, LLGL1" 180 565 16792 2.476696165 0.962203623 1 1 GOTERM_BP_DIRECT GO:0000165~MAPK cascade 9 0.029381999 0.007153156 "MAP3K1, DLG4, RASA1, RASGRF1, PEA15, FGF20, PTK2B, FYN, IL17RD" 180 262 16792 3.204580153 0.999625369 1 1 GOTERM_BP_DIRECT GO:0010628~positive regulation of gene expression 9 0.029381999 0.007153156 "WNT10A, DNMT1, PLAG1, ITGB8, CTSH, HMGA2, MSN, IQGAP3, TGFBR1" 180 262 16792 3.204580153 0.999625369 1 1 GOTERM_BP_DIRECT GO:0007411~axon guidance 7 0.022852666 0.007198587 "NGFR, DRAXIN, NRP2, RANBP9, FYN, SLIT2, EPHB3" 180 159 16792 4.107058001 0.999643743 1 1 GOTERM_BP_DIRECT GO:2000310~regulation of N-methyl-D-aspartate selective glutamate receptor activity 3 0.009794 0.010830964 "DLG4, RASGRF1, PTK2B" 180 15 16792 18.65777778 0.999993657 1 1 GOTERM_BP_DIRECT GO:0030900~forebrain development 4 0.013058666 0.012924724 "DRAXIN, DLC1, FYN, SSTR3" 180 46 16792 8.112077295 0.999999382 1 1 GOTERM_BP_DIRECT GO:0051056~regulation of small GTPase mediated signal transduction 6 0.019587999 0.014419947 "PLEKHG5, DLC1, ARHGAP19, SIPA1L2, SRGAP2, ARHGAP23" 180 134 16792 4.177114428 0.999999883 1 1 GOTERM_BP_DIRECT GO:0043065~positive regulation of apoptotic process 9 0.029381999 0.015297902 "NGFR, USP27X, PNMA1, PLEKHG5, CYP1B1, HMGA2, ANO6, IRF5, SLIT2" 180 300 16792 2.798666667 0.999999956 1 1 GOTERM_BP_DIRECT GO:0008360~regulation of cell shape 6 0.019587999 0.01712336 "EPS8, RASA1, DLC1, PTK2B, MSN, FYN" 180 140 16792 3.998095238 0.999999994 1 1 GOTERM_BP_DIRECT GO:0031290~retinal ganglion cell axon guidance 3 0.009794 0.017154317 "NRCAM, SLIT2, EPHB3" 180 19 16792 14.72982456 0.999999994 1 1 GOTERM_BP_DIRECT GO:0030336~negative regulation of cell migration 5 0.016323333 0.018762177 "DLC1, PKP2, CYP1B1, EPPK1, SLIT2" 180 95 16792 4.90994152 0.999999999 1 1 GOTERM_BP_DIRECT GO:0006357~regulation of transcription from RNA polymerase II promoter 11 0.035911332 0.020039581 "KLF12, CBFB, ACTL6A, NRIP1, CHD4, STAT6, IRF5, IKZF3, MAMLD1, RUNX2, TRAK2" 180 441 16792 2.326933736 1 1 1 GOTERM_BP_DIRECT GO:0018108~peptidyl-tyrosine phosphorylation 6 0.019587999 0.024101074 "PEAK1, FGF20, PTK2B, FYN, MET, EPHB3" 180 153 16792 3.6583878 1 1 1 GOTERM_BP_DIRECT GO:0042981~regulation of apoptotic process 7 0.022852666 0.026869779 "NGFR, RASSF5, PEA15, TP53BP2, FYN, NOD1, IKZF3" 180 213 16792 3.065832029 1 1 1 GOTERM_BP_DIRECT GO:0009967~positive regulation of signal transduction 4 0.013058666 0.027303525 "EPS8, LASP1, CNTNAP1, SKAP2" 180 61 16792 6.117304189 1 1 1 GOTERM_BP_DIRECT GO:0035556~intracellular signal transduction 10 0.032646665 0.029041489 "PRKD3, RASA1, RASSF5, RASGRF1, PPP1R1B, FYN, NOD1, DEF8, CORO2A, TGFBR1" 180 403 16792 2.314860766 1 1 1 GOTERM_BP_DIRECT GO:0034334~adherens junction maintenance 2 0.006529333 0.031641693 "AFDN, PKP2" 180 3 16792 62.19259259 1 1 1 GOTERM_BP_DIRECT GO:0048863~stem cell differentiation 3 0.009794 0.033312791 "HMGA2, RUNX2, PHF19" 180 27 16792 10.3654321 1 1 1 GOTERM_BP_DIRECT GO:0006461~protein complex assembly 5 0.016323333 0.035607771 "DLG4, RANBP9, PTK2B, LLGL1, SKAP2" 180 116 16792 4.021072797 1 1 1 GOTERM_BP_DIRECT GO:0072675~osteoclast fusion 2 0.006529333 0.04196608 "DCSTAMP, CD109" 180 4 16792 46.64444444 1 1 1 GOTERM_BP_DIRECT GO:0006493~protein O-linked glycosylation 3 0.009794 0.045480665 "GALNT7, GCNT4, TRAK2" 180 32 16792 8.745833333 1 1 1 GOTERM_BP_DIRECT GO:0001843~neural tube closure 4 0.013058666 0.049120149 "SDC4, DLC1, SEMA4C, PRICKLE1" 180 77 16792 4.846176046 1 1 1