positive correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0070125~mitochondrial translational elongation 6 0.021212657 0.001204752 "GADD45GIP1, MRPL41, MRPL28, MRPL23, AURKAIP1, MRPL55" 158 85 16792 7.502010424 0.545968298 0.415796698 0.415796698 GOTERM_BP_DIRECT GO:0070126~mitochondrial translational termination 6 0.021212657 0.001269608 "GADD45GIP1, MRPL41, MRPL28, MRPL23, AURKAIP1, MRPL55" 158 86 16792 7.414777745 0.564874917 0.415796698 0.415796698 GOTERM_BP_DIRECT GO:0036498~IRE1-mediated unfolded protein response 4 0.014141771 0.017792058 "ZBTB17, CXXC1, SULT1A3, ARFGAP1" 158 59 16792 7.205320747 0.999992179 1 1 GOTERM_BP_DIRECT GO:0045732~positive regulation of protein catabolic process 4 0.014141771 0.018602791 "GGA1, RHBDD3, ATG4B, VPS28" 158 60 16792 7.085232068 0.999995446 1 1 GOTERM_BP_DIRECT GO:0006400~tRNA modification 3 0.010606328 0.026164964 "QTRT1, TRMT1, TRMT61A" 158 27 16792 11.80872011 0.999999971 1 1 GOTERM_BP_DIRECT "GO:0006890~retrograde vesicle-mediated transport, Golgi to ER" 4 0.014141771 0.041548173 "PICK1, USE1, COPE, ARFGAP1" 158 82 16792 5.184316147 1 1 1 GOTERM_BP_DIRECT GO:0090238~positive regulation of arachidonic acid secretion 2 0.007070886 0.045887783 "MIF, PLA2G6" 158 5 16792 42.51139241 1 1 1 negative correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0006511~ubiquitin-dependent protein catabolic process 12 0.03533673 5.07E-06 "RNF168, USP14, USP8, ITCH, USP38, USP32, USP9X, CUL3, USP12, USP1, RLIM, ARIH1" 184 182 16792 6.017200191 0.005130568 0.005143762 0.005118423 GOTERM_BP_DIRECT "GO:0006355~regulation of transcription, DNA-templated" 34 0.100120734 7.78E-05 "GTF2A1, RSC1A1, ATF2, ZNF791, ZNF570, PHF20, RSF1, SPTY2D1, AFF4, GMCL1, SBNO1, RBBP4, RBBP5, RB1CC1, ZNF41, ZNF845, BBX, ZNF426, ZNF268, ZNF146, ZNF562, PBRM1, NUP133, CSNK2A1, EAF1, ATRX, HIPK3, REST, CSDE1, ASXL2, RLIM, CNOT9, CLOCK, ZNF134" 184 1504 16792 2.063078168 0.075972062 0.039504948 0.039310342 GOTERM_BP_DIRECT GO:0007062~sister chromatid cohesion 8 0.02355782 1.34E-04 "RANBP2, STAG1, STAG2, NUP133, KIF2A, TAOK1, SMC3, WAPL" 184 103 16792 7.088222879 0.126901937 0.045232776 0.045009955 GOTERM_BP_DIRECT GO:0032206~positive regulation of telomere maintenance 4 0.01177891 1.97E-04 "RAD50, ATRX, DHX36, NBN" 184 11 16792 33.18577075 0.181243908 0.049987339 0.049741096 GOTERM_BP_DIRECT GO:0016579~protein deubiquitination 7 0.020613092 7.48E-04 "USP14, USP8, USP38, USP32, USP9X, USP12, USP1" 184 99 16792 6.452788757 0.531996698 0.151799201 0.151051422 GOTERM_BP_DIRECT "GO:0006351~transcription, DNA-templated" 37 0.108954916 0.001073176 "PHF3, RSC1A1, ZNF791, GTF3C3, ZNF570, GTF3C4, CCNT1, PHF20, SPTY2D1, NPAT, RBBP4, RBBP5, RB1CC1, DHX36, ZNF41, ZNF845, BBX, ZNF426, MAP3K7, ZNF268, ZNF562, SMARCC1, PBRM1, CSNK2A1, ZBTB38, EAF1, ATRX, CDC5L, REST, CNOT1, ASXL2, RLIM, NAA15, ATF6, CNOT9, CLOCK, ZNF134" 184 1955 16792 1.727187813 0.663735841 0.181545555 0.180651242 GOTERM_BP_DIRECT GO:0016569~covalent chromatin modification 7 0.020613092 0.001487801 "SMARCC1, PBRM1, NCOR1, ATRX, SMARCA5, TLK1, RSF1" 184 113 16792 5.653328203 0.779364378 0.215731174 0.214668458 GOTERM_BP_DIRECT GO:0016925~protein sumoylation 7 0.020613092 0.001777161 "RNF168, RANBP2, STAG1, STAG2, NUP133, NUP155, SMC3" 184 117 16792 5.460052025 0.835595122 0.225477298 0.224366572 GOTERM_BP_DIRECT GO:0006974~cellular response to DNA damage stimulus 9 0.026502547 0.002039107 "RNF168, ATF2, RAD50, RNF169, RBBP5, ZBTB38, TAOK1, TLK1, TRIP12" 184 208 16792 3.948787625 0.874041994 0.229965964 0.228833127 GOTERM_BP_DIRECT GO:0006338~chromatin remodeling 6 0.017668365 0.00248595 "SMARCC1, PBRM1, RBBP4, ATRX, SMARCA5, RSF1" 184 86 16792 6.367037412 0.920052185 0.252323964 0.251080989 GOTERM_BP_DIRECT GO:0045732~positive regulation of protein catabolic process 5 0.014723637 0.004138365 "GSK3B, CSNK2A1, CSNK2A3, RHBDD1, ZNF268" 184 60 16792 7.605072464 0.985141097 0.367034857 0.365226804 GOTERM_BP_DIRECT GO:0006468~protein phosphorylation 13 0.038281457 0.004339328 "MAP3K2, GSK3B, CCNT1, CSNK2A1, CSNK2A3, ADAM10, HIPK3, LATS1, PIK3CA, WNK1, TAOK1, TLK1, SCYL2" 184 456 16792 2.601735317 0.987893371 0.367034857 0.365226804 GOTERM_BP_DIRECT GO:0006303~double-strand break repair via nonhomologous end joining 5 0.014723637 0.004929308 "RNF168, RAD50, RIF1, PRKDC, NBN" 184 63 16792 7.242926156 0.993366476 0.371815298 0.369983696 GOTERM_BP_DIRECT GO:0051301~cell division 11 0.032392002 0.005128487 "LATS1, STAG1, STAG2, KIF2A, CCNT1, USP9X, REEP3, CLTC, PRPF40A, SMC3, WAPL" 184 350 16792 2.868198758 0.994586221 0.371815298 0.369983696 GOTERM_BP_DIRECT GO:0006302~double-strand break repair 5 0.014723637 0.005815837 "RNF168, RAD50, PRKDC, SMARCA5, NBN" 184 66 16792 6.91370224 0.997315623 0.37708466 0.3752271 GOTERM_BP_DIRECT GO:0031122~cytoplasmic microtubule organization 4 0.01177891 0.005944192 "PCM1, SLK, SLAIN2, TUBGCP4" 184 34 16792 10.73657289 0.997645337 0.37708466 0.3752271 GOTERM_BP_DIRECT GO:0090307~mitotic spindle assembly 4 0.01177891 0.006980715 "KIF2A, CLTC, TUBGCP4, KPNB1" 184 36 16792 10.14009662 0.999183327 0.41678976 0.414736609 GOTERM_BP_DIRECT GO:1900034~regulation of cellular response to heat 5 0.014723637 0.009095787 "RANBP2, GSK3B, BAG4, NUP133, NUP155" 184 75 16792 6.084057971 0.999906211 0.512901339 0.510374732 GOTERM_BP_DIRECT GO:0006366~transcription from RNA polymerase II promoter 13 0.038281457 0.010647332 "KDM5A, ATF2, GTF2A1, SUPT16H, CCNT1, TCF12, ASH1L, AFF4, STAG1, REST, NCOR1, TRIP11, CLOCK" 184 513 16792 2.312653615 0.999980884 0.558741813 0.55598939 GOTERM_BP_DIRECT GO:0043066~negative regulation of apoptotic process 12 0.03533673 0.011340697 "GSK3B, MED1, ITCH, BAG4, PRKDC, API5, RHBDD1, NAA15, IL6ST, ZNF268, HIPK3, MTDH" 184 455 16792 2.406880076 0.999990617 0.558741813 0.55598939 GOTERM_BP_DIRECT GO:1901796~regulation of signal transduction by p53 class mediator 6 0.017668365 0.011560175 "SUPT16H, RAD50, CSNK2A1, RBBP4, PHF20, NBN" 184 124 16792 4.415848527 0.99999251 0.558741813 0.55598939 GOTERM_BP_DIRECT GO:0006281~DNA repair 8 0.02355782 0.014674459 "SUPT16H, RAD50, TAOK1, ATRX, CDC5L, TRIP12, NBN, SMC3" 184 235 16792 3.106753006 0.999999696 0.677026186 0.673691082 GOTERM_BP_DIRECT GO:0016032~viral process 9 0.026502547 0.016961822 "RANBP2, NCKAP1, RAD50, NUP133, CCNT1, NUP155, IL6ST, PDZD8, WAPL" 184 299 16792 2.746982696 0.999999971 0.700332824 0.696882908 GOTERM_BP_DIRECT GO:0016567~protein ubiquitination 10 0.029447275 0.017327203 "RNF168, MED1, ITCH, RNF169, FEM1B, CUL3, RLIM, UBR1, ARIH1, PJA2" 184 359 16792 2.542085503 0.99999998 0.700332824 0.696882908 GOTERM_BP_DIRECT GO:0046827~positive regulation of protein export from nucleus 3 0.008834182 0.017883754 "GSK3B, PPM1A, CTDSPL2" 184 19 16792 14.40961098 0.999999989 0.700332824 0.696882908 GOTERM_BP_DIRECT GO:0075733~intracellular transport of virus 4 0.01177891 0.018083376 "RANBP2, NUP133, NUP155, KPNB1" 184 51 16792 7.15771526 0.999999991 0.700332824 0.696882908 GOTERM_BP_DIRECT GO:0007050~cell cycle arrest 6 0.017668365 0.019175205 "PPM1A, CUL3, NBN, SKIL, EIF4G2, UHMK1" 184 141 16792 3.883441258 0.999999997 0.700332824 0.696882908 GOTERM_BP_DIRECT GO:0007067~mitotic nuclear division 8 0.02355782 0.019319526 "LATS1, STAG1, PBRM1, STAG2, USP9X, REEP3, CLTC, SMC3" 184 248 16792 2.943899018 0.999999997 0.700332824 0.696882908 GOTERM_BP_DIRECT GO:0017148~negative regulation of translation 4 0.01177891 0.025359709 "CNOT1, CAPRIN1, EPRS, CNOT9" 184 58 16792 6.293853073 1 0.856609336 0.852389586 GOTERM_BP_DIRECT GO:0043044~ATP-dependent chromatin remodeling 3 0.008834182 0.025719136 "SMARCC1, RBBP4, SMARCA5" 184 23 16792 11.90359168 1 0.856609336 0.852389586 GOTERM_BP_DIRECT GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process 6 0.017668365 0.026162453 "ITCH, HECTD1, CUL3, SPOPL, TRIP12, ARIH1" 184 153 16792 3.57885763 1 0.856609336 0.852389586 GOTERM_BP_DIRECT GO:0070423~nucleotide-binding oligomerization domain containing signaling pathway 3 0.008834182 0.030068413 "ITCH, TAB2, MAP3K7" 184 25 16792 10.95130435 1 0.953732483 0.949034294 GOTERM_BP_DIRECT GO:0007049~cell cycle 7 0.020613092 0.031794401 "CCNT1, RBBP4, RIF1, RB1CC1, TLK1, PRPF40A, APPL1" 184 217 16792 2.943899018 1 0.977918704 0.973101371 GOTERM_BP_DIRECT GO:0035329~hippo signaling 3 0.008834182 0.034686541 "LATS1, MOB1A, PJA2" 184 27 16792 10.14009662 1 1 0.996055227 GOTERM_BP_DIRECT GO:0033138~positive regulation of peptidyl-serine phosphorylation 4 0.01177891 0.040961678 "LATS1, GSK3B, BAG4, PIK3CA" 184 70 16792 5.214906832 1 1 0.996055227 GOTERM_BP_DIRECT GO:0045773~positive regulation of axon extension 3 0.008834182 0.042088279 "GSK3B, GOLGA4, EIF4G2" 184 30 16792 9.126086957 1 1 0.996055227 GOTERM_BP_DIRECT GO:0000972~transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery 2 0.005889455 0.042888514 "NUP133, NUP155" 184 4 16792 45.63043478 1 1 0.996055227 GOTERM_BP_DIRECT GO:0031860~telomeric 3' overhang formation 2 0.005889455 0.042888514 "RAD50, NBN" 184 4 16792 45.63043478 1 1 0.996055227 GOTERM_BP_DIRECT GO:0006886~intracellular protein transport 7 0.020613092 0.044655782 "SEC24B, CLTC, TLK1, RAB3GAP2, VPS35, KPNB1, ARCN1" 184 236 16792 2.706890199 1 1 0.996055227 GOTERM_BP_DIRECT GO:0001889~liver development 4 0.01177891 0.047021331 "MED1, PIK3CA, RB1CC1, NF1" 184 74 16792 4.933019976 1 1 0.996055227 GOTERM_BP_DIRECT GO:0006409~tRNA export from nucleus 3 0.008834182 0.047320182 "RANBP2, NUP133, NUP155" 184 32 16792 8.555706522 1 1 0.996055227