positive correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0055085~transmembrane transport 11 0.038725576 1.68E-04 "SLC22A23, SLC5A8, ABCC8, BCL2, VDAC3, APOA1, KCNAB1, SLC25A42, SLC16A2, CYB561, SLC25A47" 168 244 16792 4.506049961 0.15406735 0.167301438 0.167301438 GOTERM_BP_DIRECT GO:0055114~oxidation-reduction process 15 0.052807604 0.002400799 "MIOX, ERO1B, HGD, FAXDC2, DIO1, HSD17B3, KCNAB1, CYP46A1, SOD3, QDPR, TPO, LDHD, MSRB2, BCO2, CYB561" 168 592 16792 2.53257722 0.908082167 1 1 GOTERM_BP_DIRECT GO:0032469~endoplasmic reticulum calcium ion homeostasis 3 0.010561521 0.009481993 "WFS1, BCL2, ITPR1" 168 15 16792 19.99047619 0.999922136 1 1 GOTERM_BP_DIRECT GO:1901379~regulation of potassium ion transmembrane transport 3 0.010561521 0.009481993 "DPP6, KCNIP3, KCNAB1" 168 15 16792 19.99047619 0.999922136 1 1 GOTERM_BP_DIRECT GO:0071276~cellular response to cadmium ion 3 0.010561521 0.012122742 "MT1F, MT1G, MT1H" 168 17 16792 17.63865546 0.999994504 1 1 GOTERM_BP_DIRECT GO:1903959~regulation of anion transmembrane transport 3 0.010561521 0.012122742 "CLCNKB, VDAC3, CLCNKA" 168 17 16792 17.63865546 0.999994504 1 1 GOTERM_BP_DIRECT GO:0071310~cellular response to organic substance 3 0.010561521 0.012122742 "CUX2, ABCC8, BCL2" 168 17 16792 17.63865546 0.999994504 1 1 GOTERM_BP_DIRECT GO:0071294~cellular response to zinc ion 3 0.010561521 0.015045922 "MT1F, MT1G, MT1H" 168 19 16792 15.78195489 0.99999971 1 1 GOTERM_BP_DIRECT GO:0045926~negative regulation of growth 3 0.010561521 0.015045922 "MT1F, MT1G, MT1H" 168 19 16792 15.78195489 0.99999971 1 1 GOTERM_BP_DIRECT GO:0042593~glucose homeostasis 5 0.017602535 0.01828421 "ERO1B, IRS1, WFS1, ADIPOR2, STXBP5L" 168 101 16792 4.948137671 0.999999989 1 1 GOTERM_BP_DIRECT GO:0006810~transport 9 0.031684563 0.023272129 "SLC25A15, CACNB4, CLCNKB, CLCNKA, SLC16A2, GRIN2C, SLC4A4, SLC25A47, SLC27A4" 168 348 16792 2.584975369 1 1 1 GOTERM_BP_DIRECT GO:0017157~regulation of exocytosis 3 0.010561521 0.027330081 "LGI3, HAP1, STXBP5L" 168 26 16792 11.53296703 1 1 1 GOTERM_BP_DIRECT GO:0033077~T cell differentiation in thymus 3 0.010561521 0.029326794 "BCL2, FZD8, RAG2" 168 27 16792 11.10582011 1 1 1 GOTERM_BP_DIRECT GO:0007015~actin filament organization 4 0.014082028 0.034975596 "BCL2, INPPL1, LMOD1, SORBS2" 168 72 16792 5.552910053 1 1 1 GOTERM_BP_DIRECT GO:0007275~multicellular organism development 11 0.038725576 0.035646428 "BEX3, CUX2, HLF, SPATA24, ZNF536, SPATA2, EBF4, KCTD15, WNT4, DLL3, TCFL5" 168 521 16792 2.110318984 1 1 1 GOTERM_BP_DIRECT GO:0007584~response to nutrient 4 0.014082028 0.037479044 "APOA1, ADIPOR2, AACS, SLC27A4" 168 74 16792 5.402831403 1 1 1 GOTERM_BP_DIRECT GO:0046676~negative regulation of insulin secretion 3 0.010561521 0.037864596 "ABCC8, IRS1, STXBP5L" 168 31 16792 9.67281106 1 1 1 GOTERM_BP_DIRECT GO:0002326~B cell lineage commitment 2 0.007041014 0.039194778 "BCL2, RAG2" 168 4 16792 49.97619048 1 1 1 GOTERM_BP_DIRECT GO:0002931~response to ischemia 3 0.010561521 0.042446288 "BCL2, HYOU1, PPARGC1A" 168 33 16792 9.086580087 1 1 1 GOTERM_BP_DIRECT GO:0006813~potassium ion transport 4 0.014082028 0.048378963 "SLC24A3, ABCC8, KCNK16, KCNAB1" 168 82 16792 4.8757259 1 1 1 GOTERM_BP_DIRECT GO:0045927~positive regulation of growth 2 0.007041014 0.048752467 "WFS1, TFCP2L1" 168 5 16792 39.98095238 1 1 1 GOTERM_BP_DIRECT GO:0051453~regulation of intracellular pH 3 0.010561521 0.049682336 "SLC26A7, SLC26A4, SLC4A4" 168 36 16792 8.329365079 1 1 1 negative correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0098609~cell-cell adhesion 12 0.039632737 1.12E-04 "CAST, LAD1, LASP1, ATIC, CTTN, DOCK9, PERP, TACSTD2, SNX9, IQGAP1, PPL, SPTBN2" 173 271 16792 4.298018472 0.116720479 0.0938021 0.093547203 GOTERM_BP_DIRECT GO:0042060~wound healing 7 0.023119096 1.70E-04 "ERBB3, SDC4, FN1, TIMP1, TGFBR1, EREG, DCBLD2" 173 80 16792 8.493063584 0.171070477 0.0938021 0.093547203 GOTERM_BP_DIRECT GO:0007155~cell adhesion 15 0.049540921 2.76E-04 "CDSN, LAMB3, ITGA3, FN1, EMP2, PTPRF, CLDN10, CTNNA1, CYP1B1, ITGB8, CD47, NECTIN4, MFGE8, DSC2, ARF6" 173 459 16792 3.172012543 0.262745209 0.101593218 0.10131715 GOTERM_BP_DIRECT GO:2001237~negative regulation of extrinsic apoptotic signaling pathway 5 0.01651364 5.98E-04 "ACVR1, LGALS3, CTTN, SGMS1, TGFBR1" 173 38 16792 12.77152419 0.483301677 0.13252629 0.132166165 GOTERM_BP_DIRECT GO:0008360~regulation of cell shape 8 0.026421824 6.00E-04 "EPS8, ANXA1, RASA1, PALM, FN1, PLXNB2, MSN, ARAP1" 173 140 16792 5.546490504 0.484609488 0.13252629 0.132166165 GOTERM_BP_DIRECT GO:0010628~positive regulation of gene expression 10 0.033027281 0.001542361 "WNT10A, ERBB3, SGMS1, ITGA3, LCN2, FN1, ITGB8, CTSH, MSN, TGFBR1" 173 262 16792 3.70471694 0.818060406 0.248745511 0.248069572 GOTERM_BP_DIRECT GO:0050900~leukocyte migration 7 0.023119096 0.001606437 "LYN, GRB7, ITGA3, PROS1, FN1, MSN, CD47" 173 122 16792 5.569222022 0.830505051 0.248745511 0.248069572 GOTERM_BP_DIRECT GO:0008544~epidermis development 6 0.019816368 0.001802504 "CDSN, LAMB3, ELF3, BNC1, POU2F3, KLK7" 173 85 16792 6.851547093 0.863544907 0.248745511 0.248069572 GOTERM_BP_DIRECT GO:0001525~angiogenesis 9 0.029724552 0.002136625 "TNFRSF12A, TMPRSS6, CXCL17, FN1, CYP1B1, MFGE8, PLCD3, EPHB3, EREG" 173 223 16792 3.917364369 0.905707888 0.262092686 0.261380478 GOTERM_BP_DIRECT GO:0030198~extracellular matrix organization 8 0.026421824 0.004110113 "SPINT1, LAMB3, ELF3, TMPRSS6, ITGA3, FN1, ITGB8, CD47" 173 196 16792 3.961778931 0.989400151 0.416776082 0.415643539 GOTERM_BP_DIRECT GO:0002576~platelet degranulation 6 0.019816368 0.00415266 "LYN, SERPINA1, PROS1, FN1, FLNA, TIMP1" 173 103 16792 5.654189348 0.989888505 0.416776082 0.415643539 GOTERM_BP_DIRECT GO:0018108~peptidyl-tyrosine phosphorylation 7 0.023119096 0.004949099 "LYN, ERBB3, EPHA10, MST1R, MET, EPHB3, EREG" 173 153 16792 4.44081756 0.995819695 0.455317152 0.454079877 GOTERM_BP_DIRECT GO:0051764~actin crosslink formation 3 0.009908184 0.005399096 "EPS8, FLNA, PLS3" 173 11 16792 26.4718865 0.997462946 0.45850788 0.457261935 GOTERM_BP_DIRECT GO:0007162~negative regulation of cell adhesion 4 0.013210912 0.006355294 "ERBB3, RASA1, PLXNB2, MUC21" 173 37 16792 10.49336041 0.999122676 0.501160295 0.499798446 GOTERM_BP_DIRECT GO:0007165~signal transduction 22 0.072660017 0.007861965 "LYN, GRB7, UNC5CL, ANXA1, SDC4, IFNGR1, STAC, MST1R, ARAP1, IQGAP1, IL17RD, ADCY8, TGFBR1, RUNX1, EPS8, INPP4A, ERBB3, RASA1, S100A6, ZNF217, PDE5A, MET" 173 1161 16792 1.83927549 0.999835715 0.578640588 0.577068195 GOTERM_BP_DIRECT GO:0006811~ion transport 6 0.019816368 0.009922445 "GABRB2, CLDN10, LASP1, LCN2, TMC6, CLDN16" 173 127 16792 4.585681125 0.999983449 0.684648723 0.682788265 GOTERM_BP_DIRECT GO:0031532~actin cytoskeleton reorganization 4 0.013210912 0.012311973 "EPS8, ANXA1, CTTN, FLNA" 173 47 16792 8.260730537 0.999998851 0.755134322 0.753082327 GOTERM_BP_DIRECT GO:0045860~positive regulation of protein kinase activity 4 0.013210912 0.012311973 "SDC4, SNX9, IQGAP1, EREG" 173 47 16792 8.260730537 0.999998851 0.755134322 0.753082327 GOTERM_BP_DIRECT "GO:0045892~negative regulation of transcription, DNA-templated" 12 0.039632737 0.013899145 "ELF3, TMPRSS6, BASP1, HMGA1, ZNF217, AHR, PRICKLE1, RUNX2, EREG, ARNTL, RUNX1, GATAD2A" 173 499 16792 2.3341944 0.999999805 0.807613475 0.805418873 GOTERM_BP_DIRECT GO:0007173~epidermal growth factor receptor signaling pathway 4 0.013210912 0.019691191 "EPS8, GRB7, IQGAP1, EREG" 173 56 16792 6.93311313 1 1 0.998186763 GOTERM_BP_DIRECT GO:0034394~protein localization to cell surface 3 0.009908184 0.021066112 "FLNA, EMP2, ARF6" 173 22 16792 13.23594325 1 1 0.998186763 GOTERM_BP_DIRECT GO:0008284~positive regulation of cell proliferation 11 0.036330009 0.02195593 "LYN, BNC1, FN1, CTSH, EMP2, CD47, TIMP1, MST1R, TGFBR1, RUNX2, EREG" 173 466 16792 2.291200476 1 1 0.998186763 GOTERM_BP_DIRECT GO:0007010~cytoskeleton organization 6 0.019816368 0.025110907 "PALM, MICAL2, MSN, WTIP, PPL, SPTBN2" 173 161 16792 3.617276415 1 1 0.998186763 GOTERM_BP_DIRECT GO:0051491~positive regulation of filopodium assembly 3 0.009908184 0.028860091 "PALM, ARAP1, TGFBR1" 173 26 16792 11.19964429 1 1 0.998186763 GOTERM_BP_DIRECT GO:0043547~positive regulation of GTPase activity 12 0.039632737 0.031176304 "TBC1D2, ERBB3, DOCK9, RASGEF1B, RASA1, SNX9, ASAP2, ARAP1, IQGAP1, LLGL1, EREG, SPTBN2" 173 565 16792 2.061527444 1 1 0.998186763 GOTERM_BP_DIRECT GO:0010951~negative regulation of endopeptidase activity 5 0.01651364 0.035876117 "CAST, SERPINA1, SPINT1, PROS1, TIMP1" 173 121 16792 4.010891893 1 1 0.998186763 GOTERM_BP_DIRECT GO:0071773~cellular response to BMP stimulus 3 0.009908184 0.037617066 "ACVR1, SPINT1, RUNX2" 173 30 16792 9.706358382 1 1 0.998186763 GOTERM_BP_DIRECT "GO:0045893~positive regulation of transcription, DNA-templated" 11 0.036330009 0.039544451 "ACVR1, ELF3, SERTAD2, NRIP1, HMGA1, AHR, TGFBR1, RUNX2, CREB5, ARNTL, RUNX1" 173 515 16792 2.073202761 1 1 0.998186763 GOTERM_BP_DIRECT GO:0022617~extracellular matrix disassembly 4 0.013210912 0.043115485 "LAMB3, FN1, TIMP1, KLK7" 173 76 16792 5.108609674 1 1 0.998186763 GOTERM_BP_DIRECT GO:0001843~neural tube closure 4 0.013210912 0.044536943 "SDC4, SPINT1, PLXNB2, PRICKLE1" 173 77 16792 5.042264094 1 1 0.998186763 GOTERM_BP_DIRECT GO:0030036~actin cytoskeleton organization 5 0.01651364 0.044749892 "SPECC1, INF2, FLII, SHROOM4, AMOT" 173 130 16792 3.733214762 1 1 0.998186763 GOTERM_BP_DIRECT GO:0071526~semaphorin-plexin signaling pathway 3 0.009908184 0.044762732 "PLXNB2, FLNA, MET" 173 33 16792 8.823962165 1 1 0.998186763 GOTERM_BP_DIRECT GO:0043588~skin development 3 0.009908184 0.047247572 "WNT10A, GJB3, ITGA3" 173 34 16792 8.564433866 1 1 0.998186763 GOTERM_BP_DIRECT GO:0001932~regulation of protein phosphorylation 3 0.009908184 0.047247572 "LYN, FN1, PLXNB2" 173 34 16792 8.564433866 1 1 0.998186763 GOTERM_BP_DIRECT GO:0017158~regulation of calcium ion-dependent exocytosis 3 0.009908184 0.04978174 "SYT12, C2CD4A, SYTL5" 173 35 16792 8.319735756 1 1 0.998186763