positive correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0045926~negative regulation of growth 5 0.017266982 3.03E-05 "MT1M, MT1F, MT1G, MT1H, MT1E" 165 19 16792 26.7814992 0.031306281 0.015903157 0.015812196 GOTERM_BP_DIRECT GO:0071294~cellular response to zinc ion 5 0.017266982 3.03E-05 "MT1M, MT1F, MT1G, MT1H, MT1E" 165 19 16792 26.7814992 0.031306281 0.015903157 0.015812196 GOTERM_BP_DIRECT GO:0071276~cellular response to cadmium ion 4 0.013813586 5.62E-04 "MT1F, MT1G, MT1H, MT1E" 165 17 16792 23.94581105 0.445755161 0.17572971 0.174724583 GOTERM_BP_DIRECT GO:0043691~reverse cholesterol transport 4 0.013813586 6.70E-04 "SCARB1, APOA1, APOA4, APOA5" 165 18 16792 22.61548822 0.504978683 0.17572971 0.174724583 GOTERM_BP_DIRECT GO:0030300~regulation of intestinal cholesterol absorption 3 0.010360189 9.30E-04 "APOA1, APOA4, APOA5" 165 5 16792 61.06181818 0.62316675 0.195099729 0.19398381 GOTERM_BP_DIRECT GO:0033344~cholesterol efflux 4 0.013813586 0.001796384 "SCARB1, APOA1, APOA4, APOA5" 165 25 16792 16.28315152 0.848338113 0.267918578 0.266386155 GOTERM_BP_DIRECT GO:0070328~triglyceride homeostasis 4 0.013813586 0.002016233 "SCARB1, APOA1, APOA4, APOA5" 165 26 16792 15.65687646 0.87962741 0.267918578 0.266386155 GOTERM_BP_DIRECT GO:0010898~positive regulation of triglyceride catabolic process 3 0.010360189 0.002554038 "APOA1, APOA4, APOA5" 165 8 16792 38.16363636 0.931615766 0.267918578 0.266386155 GOTERM_BP_DIRECT GO:0034380~high-density lipoprotein particle assembly 3 0.010360189 0.002554038 "APOA1, APOA4, APOA5" 165 8 16792 38.16363636 0.931615766 0.267918578 0.266386155 GOTERM_BP_DIRECT GO:0031102~neuron projection regeneration 3 0.010360189 0.002554038 "APOA1, APOA4, APOA5" 165 8 16792 38.16363636 0.931615766 0.267918578 0.266386155 GOTERM_BP_DIRECT GO:0010873~positive regulation of cholesterol esterification 3 0.010360189 0.003262738 "APOA1, APOA4, APOA5" 165 9 16792 33.92323232 0.967554961 0.311146547 0.309366872 GOTERM_BP_DIRECT GO:0045723~positive regulation of fatty acid biosynthetic process 3 0.010360189 0.004052329 "APOA1, APOA4, APOA5" 165 10 16792 30.53090909 0.985871057 0.326991809 0.325121503 GOTERM_BP_DIRECT GO:0051006~positive regulation of lipoprotein lipase activity 3 0.010360189 0.004052329 "APOA1, APOA4, APOA5" 165 10 16792 30.53090909 0.985871057 0.326991809 0.325121503 GOTERM_BP_DIRECT GO:0042157~lipoprotein metabolic process 4 0.013813586 0.006005759 "SCARB1, APOA1, APOA4, APOA5" 165 38 16792 10.71259968 0.998198319 0.450002914 0.447429017 GOTERM_BP_DIRECT GO:0006810~transport 10 0.034533964 0.007271733 "GABRB3, SLC25A15, SLC7A6, CACNB4, CLCNKB, CLCNKA, SLC16A2, GRIN2C, SLC4A4, SLC27A4" 165 348 16792 2.92441658 0.999526765 0.492869705 0.490050622 GOTERM_BP_DIRECT GO:0001658~branching involved in ureteric bud morphogenesis 4 0.013813586 0.007944035 "PAX8, BCL2, PGF, WNT4" 165 42 16792 9.692352092 0.999767488 0.492869705 0.490050622 GOTERM_BP_DIRECT GO:0033700~phospholipid efflux 3 0.010360189 0.007987402 "APOA1, APOA4, APOA5" 165 14 16792 21.80779221 0.99977791 0.492869705 0.490050622 GOTERM_BP_DIRECT GO:0034375~high-density lipoprotein particle remodeling 3 0.010360189 0.0091575 "SCARB1, APOA1, APOA4" 165 15 16792 20.35393939 0.999935605 0.505590373 0.502698531 GOTERM_BP_DIRECT GO:0032469~endoplasmic reticulum calcium ion homeostasis 3 0.010360189 0.0091575 "WFS1, BCL2, ITPR1" 165 15 16792 20.35393939 0.999935605 0.505590373 0.502698531 GOTERM_BP_DIRECT GO:2001234~negative regulation of apoptotic signaling pathway 3 0.010360189 0.01039907 "CTH, BCL2, WNT4" 165 16 16792 19.08181818 0.999982716 0.545431208 0.542311487 GOTERM_BP_DIRECT GO:1903959~regulation of anion transmembrane transport 3 0.010360189 0.011710623 "CLCNKB, VDAC3, CLCNKA" 165 17 16792 17.95935829 0.9999957 0.584973476 0.581627584 GOTERM_BP_DIRECT GO:1902476~chloride transmembrane transport 5 0.017266982 0.013073691 "GABRB3, CLCNKB, CLCNKA, SLC26A7, SLC26A4" 165 93 16792 5.471489084 0.999998989 0.623377337 0.619811785 GOTERM_BP_DIRECT GO:0042632~cholesterol homeostasis 4 0.013813586 0.024686585 "SCARB1, APOA1, APOA4, APOA5" 165 64 16792 6.360606061 1 1 0.995229008 GOTERM_BP_DIRECT GO:0017157~regulation of exocytosis 3 0.010360189 0.026428599 "LGI3, HAP1, STXBP5L" 165 26 16792 11.74265734 1 1 0.995229008 GOTERM_BP_DIRECT GO:0033077~T cell differentiation in thymus 3 0.010360189 0.028362718 "BCL2, FZD8, RAG2" 165 27 16792 11.30774411 1 1 0.995229008 GOTERM_BP_DIRECT GO:0007275~multicellular organism development 11 0.037987361 0.032063679 "CUX2, DPY19L2, PAX8, TBX22, ZNF536, SPATA2, ID3, EBF4, KCTD15, WNT4, TCFL5" 165 521 16792 2.14868842 1 1 0.995229008 GOTERM_BP_DIRECT GO:0055085~transmembrane transport 7 0.024173775 0.032898656 "SLC22A23, SLC5A8, BCL2, VDAC3, APOA1, SLC16A2, CYB561" 165 244 16792 2.919622454 1 1 0.995229008 GOTERM_BP_DIRECT GO:0007507~heart development 6 0.020720378 0.03365438 "GATA5, ID3, FGF12, ADIPOR2, TDGF1, HSPB11" 165 183 16792 3.336711376 1 1 0.995229008 GOTERM_BP_DIRECT GO:0006898~receptor-mediated endocytosis 6 0.020720378 0.035971371 "SCARB1, APOA1, HYOU1, PLA2R1, LRP1B, HSP90B1" 165 186 16792 3.282893451 1 1 0.995229008 GOTERM_BP_DIRECT GO:0002326~B cell lineage commitment 2 0.006906793 0.038501015 "BCL2, RAG2" 165 4 16792 50.88484848 1 1 0.995229008 GOTERM_BP_DIRECT GO:0043524~negative regulation of neuron apoptotic process 5 0.017266982 0.040538451 "GABRB3, WFS1, BCL2, PPARGC1A, LGMN" 165 132 16792 3.854912764 1 1 0.995229008 GOTERM_BP_DIRECT GO:0002931~response to ischemia 3 0.010360189 0.041079132 "BCL2, HYOU1, PPARGC1A" 165 33 16792 9.251790634 1 1 0.995229008 GOTERM_BP_DIRECT GO:0007605~sensory perception of sound 5 0.017266982 0.041489462 "GABRB3, ADGRV1, WFS1, SLC26A4, OTOS" 165 133 16792 3.825928458 1 1 0.995229008 GOTERM_BP_DIRECT GO:0045927~positive regulation of growth 2 0.006906793 0.047893785 "WFS1, TFCP2L1" 165 5 16792 40.70787879 1 1 0.995229008 GOTERM_BP_DIRECT GO:0051453~regulation of intracellular pH 3 0.010360189 0.048098497 "SLC26A7, SLC26A4, SLC4A4" 165 36 16792 8.480808081 1 1 0.995229008 negative correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0001525~angiogenesis 11 0.03776435 1.18E-04 "TNFRSF12A, TMPRSS6, CXCL17, FN1, CYP1B1, PTK2B, COL8A1, MFGE8, PLCD3, EPHB3, EREG" 176 223 16792 4.706278027 0.128409372 0.137427294 0.137427294 GOTERM_BP_DIRECT GO:0007155~cell adhesion 15 0.051496842 3.30E-04 "CDSN, ITGA3, MYBPH, FN1, PTPRF, ICAM1, CLDN10, CYP1B1, COL8A1, CD47, PLXNC1, NECTIN4, MFGE8, DSC2, ARF6" 176 459 16792 3.117944147 0.318086796 0.191394889 0.191394889 GOTERM_BP_DIRECT GO:0008360~regulation of cell shape 8 0.027464982 6.65E-04 "EPS8, ANXA1, PALM, FN1, PTK2B, MSN, ARAP1, ICAM1" 176 140 16792 5.451948052 0.538081368 0.25736989 0.25736989 GOTERM_BP_DIRECT GO:0042060~wound healing 6 0.020598737 0.001485551 "ERBB3, SDC4, FN1, TIMP1, TGFBR1, EREG" 176 80 16792 7.155681818 0.822006326 0.407210613 0.407210613 GOTERM_BP_DIRECT GO:0050900~leukocyte migration 7 0.024031859 0.001753706 "GRB7, ITGA3, PROS1, FN1, MSN, CD47, ICAM1" 176 122 16792 5.474292101 0.869690185 0.407210613 0.407210613 GOTERM_BP_DIRECT GO:0051491~positive regulation of filopodium assembly 4 0.013732491 0.002425133 "PALM, ARAP1, ESPN, TGFBR1" 176 26 16792 14.67832168 0.940334396 0.469263327 0.469263327 GOTERM_BP_DIRECT GO:0030198~extracellular matrix organization 8 0.027464982 0.004515875 "SPINT1, ELF3, TMPRSS6, ITGA3, FN1, COL8A1, CD47, ICAM1" 176 196 16792 3.894248609 0.994777632 0.748990053 0.748990053 GOTERM_BP_DIRECT GO:0098609~cell-cell adhesion 9 0.030898105 0.007592893 "LAD1, ATIC, CTTN, PPP1R13L, DOCK9, PERP, TACSTD2, VASN, SPTBN2" 176 271 16792 3.168567595 0.999856473 1 1 GOTERM_BP_DIRECT GO:0030838~positive regulation of actin filament polymerization 4 0.013732491 0.011457476 "CTTN, PTK2B, ICAM1, ARF6" 176 45 16792 8.480808081 0.999998453 1 1 GOTERM_BP_DIRECT GO:0008544~epidermis development 5 0.017165614 0.011996558 "CDSN, ELF3, BNC1, POU2F3, KLK7" 176 85 16792 5.612299465 0.999999179 1 1 GOTERM_BP_DIRECT GO:0031532~actin cytoskeleton reorganization 4 0.013732491 0.01289626 "EPS8, ANXA1, CTTN, FLNA" 176 47 16792 8.119922631 0.999999715 1 1 GOTERM_BP_DIRECT GO:0007165~signal transduction 21 0.072095578 0.018366273 "GRB7, UNC5CL, RTKN, ANXA1, SDC4, STAC, NOD1, ARAP1, ADCY8, TGFBR1, ARHGAP23, RUNX1, EPS8, ERBB3, PPP1R1B, ADORA1, PTK2B, ZNF217, PDE5A, RIN1, MET" 176 1161 16792 1.72574583 1 1 1 GOTERM_BP_DIRECT GO:0007173~epidermal growth factor receptor signaling pathway 4 0.013732491 0.020601883 "EPS8, GRB7, PTK2B, EREG" 176 56 16792 6.814935065 1 1 1 GOTERM_BP_DIRECT GO:0018108~peptidyl-tyrosine phosphorylation 6 0.020598737 0.021990412 "ERBB3, EPHA10, PTK2B, MET, EPHB3, EREG" 176 153 16792 3.741532977 1 1 1 GOTERM_BP_DIRECT GO:0002576~platelet degranulation 5 0.017165614 0.0227053 "SERPINA1, PROS1, FN1, FLNA, TIMP1" 176 103 16792 4.631509267 1 1 1 GOTERM_BP_DIRECT GO:0048041~focal adhesion assembly 3 0.010299368 0.025646901 "CTTN, RCC2, PTK2B" 176 24 16792 11.92613636 1 1 1 GOTERM_BP_DIRECT GO:2001235~positive regulation of apoptotic signaling pathway 3 0.010299368 0.027689088 "CTSH, CTSC, TGFBR1" 176 25 16792 11.44909091 1 1 1 GOTERM_BP_DIRECT GO:0045766~positive regulation of angiogenesis 5 0.017165614 0.032292487 "CTSH, CYP1B1, PTK2B, CHI3L1, RUNX1" 176 115 16792 4.148221344 1 1 1 GOTERM_BP_DIRECT GO:0034698~response to gonadotropin 2 0.006866246 0.04104298 "ITGA3, ICAM1" 176 4 16792 47.70454545 1 1 1 GOTERM_BP_DIRECT GO:0055118~negative regulation of cardiac muscle contraction 2 0.006866246 0.04104298 "ADORA1, PDE5A" 176 4 16792 47.70454545 1 1 1 GOTERM_BP_DIRECT GO:0030334~regulation of cell migration 4 0.013732491 0.042112551 "RCC2, FLNA, PLXNC1, AMOT" 176 74 16792 5.157248157 1 1 1 GOTERM_BP_DIRECT GO:0071526~semaphorin-plexin signaling pathway 3 0.010299368 0.046174928 "SEMA4C, FLNA, MET" 176 33 16792 8.673553719 1 1 1 GOTERM_BP_DIRECT GO:0090630~activation of GTPase activity 4 0.013732491 0.049500269 "PLEKHG4, TBC1D2, RCC2, PTK2B" 176 79 16792 4.830840046 1 1 1