positive correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT GO:0070125~mitochondrial translational elongation 13 0.046332597 1.35E-11 "GADD45GIP1, MRPS26, MRPS34, MRPL23, MRPL34, MRPL43, MRPL54, MRPL55, MRPL52, MRPL53, MRPL2, AURKAIP1, CHCHD1" 152 85 16792 16.89597523 8.74E-09 5.04E-09 5.01E-09 GOTERM_BP_DIRECT GO:0070126~mitochondrial translational termination 13 0.046332597 1.55E-11 "GADD45GIP1, MRPS26, MRPS34, MRPL23, MRPL34, MRPL43, MRPL54, MRPL55, MRPL52, MRPL53, MRPL2, AURKAIP1, CHCHD1" 152 86 16792 16.6995104 1.01E-08 5.04E-09 5.01E-09 GOTERM_BP_DIRECT GO:0032981~mitochondrial respiratory chain complex I assembly 9 0.032076413 9.05E-08 "NDUFB8, NDUFB7, NDUFS7, NDUFS6, NDUFB11, NDUFA2, NDUFB2, NDUFB1, NDUFAF3" 152 63 16792 15.78195489 5.87E-05 1.96E-05 1.95E-05 GOTERM_BP_DIRECT "GO:0006120~mitochondrial electron transport, NADH to ubiquinone" 8 0.028512367 2.59E-07 "NDUFB8, NDUFB7, NDUFS7, NDUFS6, NDUFB11, NDUFA2, NDUFB2, NDUFB1" 152 49 16792 18.03651987 1.68E-04 4.20E-05 4.18E-05 GOTERM_BP_DIRECT GO:0032543~mitochondrial translation 6 0.021384275 1.66E-05 "MRPL2, MRPS34, PTRH1, MRPL23, CHCHD1, MRPL57" 152 36 16792 18.4122807 0.010693841 0.002150268 0.002140329 GOTERM_BP_DIRECT GO:1902600~hydrogen ion transmembrane transport 5 0.01782023 0.002203107 "COX8A, SURF1, COX4I1, UQCR11, UQCR10" 152 61 16792 9.055220017 0.761024401 0.238302749 0.237201195 GOTERM_BP_DIRECT GO:0051604~protein maturation 3 0.010692138 0.007811224 "STUB1, LMF2, LMF1" 152 15 16792 22.09473684 0.993838209 0.633685584 0.630756374 GOTERM_BP_DIRECT "GO:0006122~mitochondrial electron transport, ubiquinol to cytochrome c" 3 0.010692138 0.007811224 "UQCC3, UQCR11, UQCR10" 152 15 16792 22.09473684 0.993838209 0.633685584 0.630756374 GOTERM_BP_DIRECT GO:0033617~mitochondrial respiratory chain complex IV assembly 3 0.010692138 0.008874783 "CHCHD5, SURF1, COX14" 152 16 16792 20.71381579 0.996928056 0.639970486 0.637012225 GOTERM_BP_DIRECT "GO:0006123~mitochondrial electron transport, cytochrome c to oxygen" 3 0.010692138 0.013725726 "COX8A, COX4I1, COX5B" 152 20 16792 16.57105263 0.999872793 0.802910846 0.799199394 GOTERM_BP_DIRECT GO:0032091~negative regulation of protein binding 4 0.014256184 0.014636107 "DNAJB2, PIN1, STUB1, PARK7" 152 57 16792 7.752539243 0.999930141 0.802910846 0.799199394 GOTERM_BP_DIRECT GO:0006888~ER to Golgi vesicle-mediated transport 6 0.021384275 0.014845809 "BCAP31, NAPA, TRAPPC6A, DCTN3, COPE, LMF1" 152 160 16792 4.142763158 0.999939154 0.802910846 0.799199394 GOTERM_BP_DIRECT GO:0006412~translation 7 0.024948321 0.026953413 "MRPL52, MRPL2, MRPL34, MRPL23, MRPL57, MRPL43, MRPL55" 152 253 16792 3.056584148 0.99999998 1 0.99691358 GOTERM_BP_DIRECT GO:0042177~negative regulation of protein catabolic process 3 0.010692138 0.033408545 "PIN1, PARK7, RILP" 152 32 16792 10.35690789 1 1 0.99691358 GOTERM_BP_DIRECT GO:0009060~aerobic respiration 3 0.010692138 0.035358039 "CHCHD5, SURF1, UQCR10" 152 33 16792 10.0430622 1 1 0.99691358 negative correlation Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_DIRECT "GO:0045893~positive regulation of transcription, DNA-templated" 19 0.055953117 8.77E-06 "KMT2E, KDM5A, ATF7IP, MED1, SMARCC1, NFYA, ZNF281, SMARCA5, RSF1, FOXN3, ELK3, PHF8, MED14, REST, SP1, KAT6A, PHIP, NAA15, BPTF" 178 515 16792 3.480397076 0.009231371 0.009274204 0.009212843 GOTERM_BP_DIRECT GO:0000209~protein polyubiquitination 10 0.029449009 1.48E-04 "NPEPPS, UBE3C, SMURF2, TNKS, SMURF1, RLIM, TRIP12, ARIH1, BIRC2, RC3H2" 178 184 16792 5.127015144 0.144641915 0.058010924 0.057627109 GOTERM_BP_DIRECT "GO:0006355~regulation of transcription, DNA-templated" 32 0.094236829 2.18E-04 "ZNF28, RSC1A1, PRDM4, TRRAP, POGK, ZBTB43, BAZ2A, RSF1, CBL, BACH1, ZNF426, ZNF623, ASCC3, ZNF146, ZKSCAN1, BPTF, ZBTB39, ZNF121, NFYA, CSNK2A1, ZNF184, ZFP69B, CDYL, BAZ1B, PTPN14, CNOT6, REST, SP1, KAT6A, RLIM, ADNP, BIRC2" 178 1504 16792 2.007171886 0.206332987 0.058010924 0.057627109 GOTERM_BP_DIRECT GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process 9 0.026504108 2.20E-04 "UBE3C, SMURF2, SMURF1, GAN, TRIP12, ARIH1, CBL, ANAPC1, CUL4B" 178 153 16792 5.549239921 0.207433116 0.058010924 0.057627109 GOTERM_BP_DIRECT "GO:0006351~transcription, DNA-templated" 38 0.111906234 2.74E-04 "ZNF28, KMT2E, PHF3, KDM5B, RSC1A1, TRRAP, ZBTB43, BAZ2A, CHD1, PHF8, ZNF426, EPC2, ZNF623, ASCC3, ZKSCAN1, BPTF, ATF7IP, ZBTB39, ZNF121, SMARCC1, CSNK2A1, ZNF184, ZNF281, ZFP69B, CDC5L, CDYL, FOXN3, BAZ1B, PTPN14, CNOT6, REST, POLR3A, KAT6A, RLIM, NAA15, ADNP, BIRC2, RCOR1" 178 1955 16792 1.833661887 0.251807057 0.058010924 0.057627109 GOTERM_BP_DIRECT GO:0006468~protein phosphorylation 15 0.044173514 3.47E-04 "CDK19, DYRK2, ROCK1, CSNK2A1, MAML1, ROCK2, CSNK2A3, ADAM10, OXSR1, STK35, PIK3CA, WNK1, PAK2, SCYL2, MAP4K4" 178 456 16792 3.103193377 0.307066202 0.061126205 0.060721778 GOTERM_BP_DIRECT GO:0006281~DNA repair 10 0.029449009 8.87E-04 "WRN, SUPT16H, MRE11, TRRAP, USP3, BOD1L1, CDC5L, TRIP12, EPC2, BACH1" 178 235 16792 4.014343772 0.608924963 0.13406277 0.133175776 GOTERM_BP_DIRECT GO:0032508~DNA duplex unwinding 5 0.014724505 0.00116578 "WRN, MRE11, G3BP1, ASCC3, CHD1" 178 44 16792 10.72012257 0.708907574 0.154174369 0.153154312 GOTERM_BP_DIRECT GO:0016567~protein ubiquitination 12 0.035338811 0.001518309 "MED1, RNF169, CAND1, SMURF1, GAN, KBTBD2, RLIM, ARIH1, CBL, BACH1, DCAF7, MIB1" 178 359 16792 3.153328534 0.799630414 0.178485663 0.177304756 GOTERM_BP_DIRECT GO:0006338~chromatin remodeling 6 0.017669405 0.002151028 "SMARCC1, SMARCA5, BAZ2A, RSF1, CHD1, BPTF" 178 86 16792 6.58165665 0.897535446 0.22757872 0.226073001 GOTERM_BP_DIRECT GO:0048511~rhythmic process 5 0.014724505 0.00250297 "KDM5B, NFYA, CSNK2A1, ROCK2, SP1" 178 54 16792 8.73491469 0.929451975 0.240740177 0.239147378 GOTERM_BP_DIRECT GO:2000145~regulation of cell motility 4 0.011779604 0.003107473 "ROCK1, ROCK2, ABL2, EGFR" 178 28 16792 13.47672552 0.962851252 0.273975531 0.272162838 GOTERM_BP_DIRECT GO:1990090~cellular response to nerve growth factor stimulus 4 0.011779604 0.00416635 "KIDINS220, CDC5L, CBL, BPTF" 178 31 16792 12.17252628 0.987932102 0.339076783 0.336833364 GOTERM_BP_DIRECT GO:0006302~double-strand break repair 5 0.014724505 0.005173793 "WRN, MRE11, SMARCA5, BAZ1B, BACH1" 178 66 16792 7.146748383 0.995864231 0.382287417 0.379758106 GOTERM_BP_DIRECT GO:0016573~histone acetylation 4 0.011779604 0.005419954 "TRRAP, KAT6A, EPC2, CDYL" 178 34 16792 11.09847984 0.996816925 0.382287417 0.379758106 GOTERM_BP_DIRECT GO:0006974~cellular response to DNA damage stimulus 8 0.023559207 0.006598846 "WRN, RNF169, MRE11, DYRK2, BOD1L1, TRIP12, CBL, BAZ1B" 178 208 16792 3.628349179 0.999092408 0.406197198 0.403509693 GOTERM_BP_DIRECT "GO:0045892~negative regulation of transcription, DNA-templated" 13 0.038283712 0.006722655 "ATF7IP, KDM5B, SMURF2, ZNF281, ARID4A, RSF1, PTPRK, FOXN3, ELK3, REST, KAT6A, RLIM, RCOR1" 178 499 16792 2.457679404 0.999204536 0.406197198 0.403509693 GOTERM_BP_DIRECT GO:0016569~covalent chromatin modification 6 0.017669405 0.006910727 "SMARCC1, NCOR1, SMARCA5, RSF1, CHD1, BPTF" 178 113 16792 5.009048424 0.999348954 0.406197198 0.403509693 GOTERM_BP_DIRECT GO:1901796~regulation of signal transduction by p53 class mediator 6 0.017669405 0.010111469 "WRN, SUPT16H, MRE11, DYRK2, CSNK2A1, KAT6A" 178 124 16792 4.564697354 0.999978606 0.563049144 0.559323867 GOTERM_BP_DIRECT GO:0030307~positive regulation of cell growth 5 0.014724505 0.011974282 "ADAM17, CSNK2A1, CSNK2A3, ADAM10, EGFR" 178 84 16792 5.615302301 0.999997084 0.633439505 0.629248507 GOTERM_BP_DIRECT GO:0006511~ubiquitin-dependent protein catabolic process 7 0.020614306 0.012787683 "USP25, UBE2H, SMURF2, USP3, RLIM, ARIH1, CUL4B" 178 182 16792 3.628349179 0.99999878 0.644255635 0.639993074 GOTERM_BP_DIRECT GO:0016032~viral process 9 0.026504108 0.014144725 "ATF7IP, DYNC1I2, MRE11, SP1, TPR, CDK13, PAK2, BICD1, RCOR1" 178 299 16792 2.839577618 0.999999715 0.680232701 0.675732106 GOTERM_BP_DIRECT GO:0007420~brain development 7 0.020614306 0.015455591 "MED1, WRN, C2CD3, SPATA5, PAFAH1B2, BPTF, PHF8" 178 190 16792 3.475576582 0.99999993 0.688061175 0.683508786 GOTERM_BP_DIRECT GO:0007264~small GTPase mediated signal transduction 8 0.023559207 0.01561749 "ARL10, MFHAS1, ARHGAP32, ARL5B, DOCK7, ITSN1, RAPGEF5, RALGPS2" 178 246 16792 3.067872476 0.999999941 0.688061175 0.683508786 GOTERM_BP_DIRECT GO:0007179~transforming growth factor beta receptor signaling pathway 5 0.014724505 0.016258534 "ITGB1, SMURF1, PTPRK, CBL, SKIL" 178 92 16792 5.127015144 0.999999971 0.688061175 0.683508786 GOTERM_BP_DIRECT GO:0001892~embryonic placenta development 3 0.008834703 0.018532807 "MED1, EGFR, BPTF" 178 20 16792 14.1505618 0.999999997 0.730274986 0.725443299 GOTERM_BP_DIRECT GO:0006357~regulation of transcription from RNA polymerase II promoter 11 0.03239391 0.018688142 "MED14, SMARCC1, ZMYM4, TCF12, SMARCA5, ATP2B4, ARID4A, CDC5L, EPC2, CHD1, BRWD3" 178 441 16792 2.353079059 0.999999998 0.730274986 0.725443299 GOTERM_BP_DIRECT GO:0006366~transcription from RNA polymerase II promoter 12 0.035338811 0.020256771 "KDM5A, REST, SUPT16H, NCOR1, NFYA, PRDM4, TCF12, HIVEP1, ARID4A, ERCC6, BACH1, ELK3" 178 513 16792 2.20671529 1 0.730274986 0.725443299 GOTERM_BP_DIRECT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 15 0.044173514 0.020319819 "KDM5A, ATF7IP, MED1, SMURF2, USP3, ZNF281, BACH1, REST, NCOR1, TPR, HIVEP1, RLIM, SKIL, RCOR1, BPTF" 178 720 16792 1.965355805 1 0.730274986 0.725443299 GOTERM_BP_DIRECT GO:0007173~epidermal growth factor receptor signaling pathway 4 0.011779604 0.021221765 "ADAM17, PIK3CA, CBL, EGFR" 178 56 16792 6.738362761 1 0.730274986 0.725443299 GOTERM_BP_DIRECT GO:0031175~neuron projection development 5 0.014724505 0.021397471 "DOCK7, PTPRK, PPP1R9A, CAMSAP1, CUL4B" 178 100 16792 4.716853933 1 0.730274986 0.725443299 GOTERM_BP_DIRECT GO:0006509~membrane protein ectodomain proteolysis 3 0.008834703 0.022224794 "ADAM17, DAG1, ADAM10" 178 22 16792 12.86414709 1 0.734807241 0.729945567 GOTERM_BP_DIRECT GO:0018108~peptidyl-tyrosine phosphorylation 6 0.017669405 0.02308058 "MAP2K4, DYRK2, PEAK1, ABL2, BAZ1B, EGFR" 178 153 16792 3.69949328 1 0.73997737 0.735081489 GOTERM_BP_DIRECT GO:0007249~I-kappaB kinase/NF-kappaB signaling 4 0.011779604 0.025414705 "ROCK1, ROCK2, TAB3, BIRC2" 178 60 16792 6.289138577 1 0.790845824 0.785613384 GOTERM_BP_DIRECT GO:0022604~regulation of cell morphogenesis 3 0.008834703 0.028276378 "ZMYM4, PHIP, CAMSAP1" 178 25 16792 11.32044944 1 0.831011335 0.82551315 GOTERM_BP_DIRECT GO:0006306~DNA methylation 3 0.008834703 0.028276378 "KMT2E, ATF7IP, BAZ2A" 178 25 16792 11.32044944 1 0.831011335 0.82551315 GOTERM_BP_DIRECT GO:0030512~negative regulation of transforming growth factor beta receptor signaling pathway 4 0.011779604 0.030020077 "ADAM17, SMURF2, SMURF1, SKIL" 178 64 16792 5.896067416 1 0.858411945 0.852732471 GOTERM_BP_DIRECT GO:0051088~PMA-inducible membrane protein ectodomain proteolysis 2 0.005889802 0.031291895 "ADAM17, ADAM10" 178 3 16792 62.89138577 1 0.871232231 0.865467934 GOTERM_BP_DIRECT GO:0051301~cell division 9 0.026504108 0.032379589 "CDK19, KIF2A, TNKS, TPR, KNL1, CDK13, CKAP5, ANAPC1, SMC2" 178 350 16792 2.425810594 1 0.878400136 0.872588415 GOTERM_BP_DIRECT GO:0007219~Notch signaling pathway 5 0.014724505 0.033462939 "ADAM17, MAML2, MAML1, ADAM10, MIB1" 178 115 16792 4.101612115 1 0.88509474 0.879238726 GOTERM_BP_DIRECT GO:0016477~cell migration 6 0.017669405 0.035689282 "ITGB1, PEAK1, ABL2, PTPRK, LAMC1, AVL9" 178 172 16792 3.290828325 1 0.920957574 0.914864282 GOTERM_BP_DIRECT GO:0033138~positive regulation of peptidyl-serine phosphorylation 4 0.011779604 0.037694601 "BAG4, PIK3CA, DOCK7, ATP2B4" 178 70 16792 5.390690209 1 0.949544938 0.943262505 GOTERM_BP_DIRECT GO:0006611~protein export from nucleus 3 0.008834703 0.039625253 "SMURF1, TPR, XPO7" 178 30 16792 9.433707865 1 0.972749204 0.966313245 GOTERM_BP_DIRECT GO:0048010~vascular endothelial growth factor receptor signaling pathway 4 0.011779604 0.040454598 "PIK3CA, ROCK1, ROCK2, PAK2" 178 72 16792 5.240948814 1 0.972749204 0.966313245 GOTERM_BP_DIRECT GO:1903347~negative regulation of bicellular tight junction assembly 2 0.005889802 0.041504614 "ROCK1, ROCK2" 178 4 16792 47.16853933 1 0.975819582 0.969363308 GOTERM_BP_DIRECT GO:0071364~cellular response to epidermal growth factor stimulus 3 0.008834703 0.047125552 "MED1, BAG4, EGFR" 178 33 16792 8.576098059 1 1 0.994323557