{"text_format":"3","workbook":"xls","n_sheets":9,"sheets":["G12C_V600E","G12C_WT","G12D_V600E","G12D_WT","G12V_V600E","G12V_WT","G13D_V600E","G13D_WT","MHB32_HCT116_DEP_filtered"],"not_rendered":{"external_links":1,"defined_names":3},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"G12C_V600E","index":0,"n_rows":17,"n_cols":9,"rows_kept":17,"merged":[[17,0,17,8]],"flags":["formulas_cached_only"]}
["Supplementary table 5A. Differentially expressed Proteins (DEPs) in RKO KRAS G12C as compared to RKO BRAF V600E."]
["Symbol","Name","Protein IDs","logFC","AveExpr","t","P","adjusted P","B"]
["TOP2A","DNA topoisomerase 2-alpha","P11388;P11388-2;P11388-3;P11388-4;J3KTB7",{"v":-1.22294151040346,"d":"-1.2"},{"v":17.6399082190929,"d":"17.6"},{"v":-6.12475122028777,"d":"-6.1"},{"v":5.43416602731613e-07,"d":"0.0"},{"v":0.000267964764769211,"d":"0.0"},{"v":6.15042120203321,"d":"6.2"}]
["LCP1","Plastin-2","P13796;Q5TBN3;P13796-2;Q5TBN5",{"v":1.44805927452587,"d":"1.4"},{"v":20.4507803397475,"d":"20.5"},{"v":5.23967592652593,"d":"5.2"},{"v":7.90780434149643e-06,"d":"0.0"},{"v":0.00159521980307096,"d":"0.0"},{"v":3.64989566741871,"d":"3.6"}]
["IFI16","Gamma-interferon-inducible protein 16","Q16666-2;Q16666;Q16666-3;Q16666-6;A0A0A0MRB1;H3BM18;X6RHM1;H3BR88;H3BVE6;X6RHR0;Q6K0P9-6;Q6K0P9-5;Q6K0P9-4;Q6K0P9-3;Q6K0P9-2;Q6K0P9",{"v":1.67581666102553,"d":"1.7"},{"v":16.6366690937998,"d":"16.6"},{"v":4.89720078134557,"d":"4.9"},{"v":2.2207577732438203e-05,"d":"0.0"},{"v":0.00281592085647316,"d":"0.0"},{"v":2.6854524362028203,"d":"2.7"}]
["S100A2","Protein S100-A2","P29034;R4GN49",{"v":1.9747307736645299,"d":"2.0"},{"v":18.3487726888154,"d":"18.3"},{"v":4.82867014166429,"d":"4.8"},{"v":2.7281264594429302e-05,"d":"0.0"},{"v":0.00310446800692505,"d":"0.0"},{"v":2.49338495089609,"d":"2.5"}]
["DNAJB11 ","DnaJ homolog subfamily B member 11","Q9UBS4;H7C2Y5",{"v":-1.18377935165935,"d":"-1.2"},{"v":13.8983819246695,"d":"13.9"},{"v":-4.71676082854431,"d":"-4.7"},{"v":3.81448356939705e-05,"d":"0.0"},{"v":0.00360184640020939,"d":"0.0"},{"v":2.18064282977351,"d":"2.2"}]
["CRABP2","Cellular retinoic acid-binding protein 2","P29373;Q5SYZ4",{"v":-1.68374219978497,"d":"-1.7"},{"v":15.9606891938136,"d":"16.0"},{"v":-4.40234468690581,"d":"-4.4"},{"v":9.71485254549155e-05,"d":"0.0"},{"v":0.00634036994071934,"d":"0.0"},{"v":1.30959753521506,"d":"1.3"}]
["SLC7A5","Large neutral amino acids transporter small subunit 1","Q01650;A0A0C4DGL4;H0YJ95;G3V4Z6;Q9UM01",{"v":-1.0543597708675,"d":"-1.1"},{"v":15.9299493981437,"d":"15.9"},{"v":-4.28432934730621,"d":"-4.3"},{"v":0.000137535345356027,"d":"0.0"},{"v":0.00735399834566321,"d":"0.0"},{"v":0.986286570555948,"d":"1.0"}]
[null,"??","Q5RHS7",{"v":1.4603448131022199,"d":"1.5"},{"v":16.9128438165901,"d":"16.9"},{"v":4.23281904120717,"d":"4.2"},{"v":0.000159965404489605,"d":"0.0"},{"v":0.00783306265144787,"d":"0.0"},{"v":0.84591009123548,"d":"0.8"}]
["S100A10","Protein S100-A10","P60903",{"v":1.19271187399887,"d":"1.2"},{"v":17.6293894507127,"d":"17.6"},{"v":4.14625297009787,"d":"4.1"},{"v":0.00020599925348061,"d":"0.0"},{"v":0.00942499677264893,"d":"0.0"},{"v":0.611101152402851,"d":"0.6"}]
["MT2A ","Metallothionein-2;Metallothionein-1G","P02795;P13640-2;P13640;H3BSF1;H3BSP9;P80294;P04731",{"v":1.5915638300883002,"d":"1.6"},{"v":17.652580771999,"d":"17.7"},{"v":3.77584601878738,"d":"3.8"},{"v":0.000598207692995138,"d":"0.0"},{"v":0.0192121786183785,"d":"0.0"},{"v":-0.375355416393594,"d":"-0.4"}]
["NXN ","Nucleoredoxin","Q6DKJ4;A0A0G2JQK5;I3L4V6;Q6DKJ4-3;A0A0C4DGI2;Q6DKJ4-2",{"v":-1.27620713038112,"d":"-1.3"},{"v":13.0023789430419,"d":"13.0"},{"v":-3.59778604579552,"d":"-3.6"},{"v":0.000987698732747475,"d":"0.0"},{"v":0.0265661028844442,"d":"0.0"},{"v":-0.836995683513869,"d":"-0.8"}]
["OCRL ","Inositol polyphosphate 5-phosphatase OCRL-1","Q01968-2;Q01968",{"v":1.06897433350229,"d":"1.1"},{"v":13.2399650349206,"d":"13.2"},{"v":3.4937442352076,"d":"3.5"},{"v":0.00131882602146552,"d":"0.0"},{"v":0.0312991972367059,"d":"0.0"},{"v":-1.1022996726973,"d":"-1.1"}]
["MT1E ","Metallothionein-1E;Metallothionein-1M","P04732;CON__P67983;Q8N339;H3BU80;Q93083;P07438;P04732-2",{"v":1.36984596817766,"d":"1.4"},{"v":15.044090159441,"d":"15.0"},{"v":3.43348309145493,"d":"3.4"},{"v":0.00155704489394276,"d":"0.0"},{"v":0.0338733590162646,"d":"0.0"},{"v":-1.25434509102037,"d":"-1.3"}]
["VAMP8 ","Vesicle-associated membrane protein 8","Q9BV40;C9JXZ5;B8ZZT4",{"v":1.06797192634329,"d":"1.1"},{"v":8.88818105984869,"d":"8.9"},{"v":3.40370958002205,"d":"3.4"},{"v":0.00168949839802898,"d":"0.0"},{"v":0.0350956812559654,"d":"0.0"},{"v":-1.32900933088267,"d":"-1.3"}]
["FLNA","Filamin-A","P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;H0Y5F3;H0Y5C6;H7C2E7",{"v":-1.36726601229939,"d":"-1.4"},{"v":19.4336119315063,"d":"19.4"},{"v":-3.20505292254559,"d":"-3.2"},{"v":0.00289219537873097,"d":"0.0"},{"v":0.0484360871351247,"d":"0.0"},{"v":-1.8189473978136301,"d":"-1.8"}]

{"sheet":"G12C_WT","index":1,"n_rows":49,"n_cols":13,"rows_kept":49,"merged":[[3,0,3,8],[4,1,4,8]],"flags":["formulas_cached_only"]}
["Supplementary table 5B. Differentially expressed Proteins (DEPs) in RKO KRAS G12C as compared to RKO BRAF WT."]
["Symbol","Name","Protein IDs","logFC","AveExpr","t","P","adjusted P","B"]
["IFI16","Gamma-interferon-inducible protein 16","Q16666-2;Q16666;Q16666-3;Q16666-6;A0A0A0MRB1;H3BM18;X6RHM1;H3BR88;H3BVE6;X6RHR0;Q6K0P9-6;Q6K0P9-5;Q6K0P9-4;Q6K0P9-3;Q6K0P9-2;Q6K0P9",{"v":1.17109335386449,"d":"1.2"},{"v":16.6366690937998,"d":"16.6"},{"v":3.42225938013062,"d":"3.4"},{"v":0.00160576077811447,"d":"0.0"},{"v":0.0445397895829501,"d":"0.0"},{"v":-1.23742153099984,"d":"-1.2"}]
{"$rows_empty":45}
[{"$nulls":12},"Supple table 5F:  Differentially expressed Proteins (DEPs) in RKO BRAFWt/-/-(KRAS G12D) as compared to RKO BRAFWt/-/- ."]

{"sheet":"G12D_V600E","index":2,"n_rows":28,"n_cols":9,"rows_kept":28,"merged":[[28,0,28,8]],"flags":["formulas_cached_only"]}
["Supplementary table 5C. Differentially expressed Proteins (DEPs) in RKO KRAS G12D as compared to RKO BRAF V600E."]
["Symbol","Name","Protein IDs","logFC","AveExpr","t","P","adjusted P","B"]
["LGALS1","Galectin-1","P09382;F8WEI7",{"v":1.65133723739995,"d":"1.7"},{"v":19.392729724959,"d":"19.4"},{"v":7.60262630550109,"d":"7.6"},{"v":6.77492982274162e-09,"d":"0.0"},{"v":1.3000260645229201e-05,"d":"0.0"},{"v":10.3307895282765,"d":"10.3"}]
["S100A10","Protein S100-A10","P60903",{"v":2.25731646077021,"d":"2.3"},{"v":17.6293894507127,"d":"17.6"},{"v":7.51308705089289,"d":"7.5"},{"v":8.787918417234731e-09,"d":"0.0"},{"v":1.3000260645229201e-05,"d":"0.0"},{"v":10.0850646472765,"d":"10.1"}]
["ANXA2","Annexin A2;Annexin;Putative annexin A2-like protein","P07355;P07355-2;H0YN42;H0YMD0;H0YMU9;H0YM50;A6NMY6;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YMM1;H0YKZ7;H0YLV6;H0YMT9;H0YKX9;H0YKL9;H0YMW4;H0YNA0;H0YN52;H0YKV8;H0YMD9;H0YNB8;H0YKN4;H0YLE2",{"v":1.11708629201476,"d":"1.1"},{"v":21.3577145853457,"d":"21.4"},{"v":7.31684366803734,"d":"7.3"},{"v":1.55870036802163e-08,"d":"0.0"},{"v":1.72937805832e-05,"d":"0.0"},{"v":9.54325746825653,"d":"9.5"}]
["PSAT1","Phosphoserine aminotransferase","Q9Y617;Q9Y617-2",{"v":-1.03914495073647,"d":"-1.0"},{"v":17.4948420149628,"d":"17.5"},{"v":-6.47703526238075,"d":"-6.5"},{"v":1.8829838268298598e-07,"d":"0.0"},{"v":5.96905873105067e-05,"d":"0.0"},{"v":7.1807724283488,"d":"7.2"}]
["CD63","Tetraspanin;CD63 antigen","F8VNT9;F8VV56;F8W022;F8VWK8;P08962-3;P08962-2;P08962",{"v":1.11479463636031,"d":"1.1"},{"v":16.0121484673804,"d":"16.0"},{"v":6.15289163451617,"d":"6.2"},{"v":4.991925217627059e-07,"d":"0.0"},{"v":0.00010070074598104,"d":"0.0"},{"v":6.25423848573408,"d":"6.3"}]
["ASNS","Asparagine synthetase [glutamine-hydrolyzing]","P08243-2;P08243;P08243-3;F8WEJ5;C9J057;C9JT45;C9JM09;C9JLN6",{"v":-1.06773694856696,"d":"-1.1"},{"v":17.751751290921298,"d":"17.8"},{"v":-5.85866732683479,"d":"-5.9"},{"v":1.21427186465959e-06,"d":"0.0"},{"v":0.000149692737093313,"d":"0.0"},{"v":5.40900390181862,"d":"5.4"}]
["GNG12","Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12","Q9UBI6",{"v":1.18728048815114,"d":"1.2"},{"v":16.9650888072936,"d":"17.0"},{"v":5.89467422234442,"d":"5.9"},{"v":1.08895742652842e-06,"d":"0.0"},{"v":0.000149692737093313,"d":"0.0"},{"v":5.5125882288270205,"d":"5.5"}]
["CTSZ","Cathepsin Z","Q9UBR2",{"v":1.05586065212715,"d":"1.1"},{"v":15.9865622380133,"d":"16.0"},{"v":5.86006380464684,"d":"5.9"},{"v":1.20915236762735e-06,"d":"0.0"},{"v":0.000149692737093313,"d":"0.0"},{"v":5.41302183302273,"d":"5.4"}]
["ITGB1","Integrin beta-1","P05556;P05556-2;P05556-5;P05556-4;P05556-3;E7EQW5;C9JPK5;Q5T3E6;E9PLR6;E7EUI6;E7ERX5;C9JJP8;Q5T3E5;E9PQJ2;H7C4N8;C9JNE0",{"v":1.06110875470083,"d":"1.1"},{"v":20.0830362216108,"d":"20.1"},{"v":5.65272753532403,"d":"5.7"},{"v":2.26498414705491e-06,"d":"0.0"},{"v":0.000231396545489224,"d":"0.0"},{"v":4.81614029859466,"d":"4.8"}]
["METTL7B","Methyltransferase-like protein 7B","A0A087WZT2;Q6UX53",{"v":1.01395860208068,"d":"1.0"},{"v":14.2522206551202,"d":"14.3"},{"v":5.53442062147465,"d":"5.5"},{"v":3.24092051485424e-06,"d":"0.0"},{"v":0.000287664104898463,"d":"0.0"},{"v":4.47545074170524,"d":"4.5"}]
["S100A2","Protein S100-A2","P29034;R4GN49",{"v":2.15612408533701,"d":"2.2"},{"v":18.3487726888154,"d":"18.3"},{"v":5.04776484938549,"d":"5.0"},{"v":1.4114924549912602e-05,"d":"0.0"},{"v":0.000720153352948322,"d":"0.0"},{"v":3.07736641655096,"d":"3.1"}]
["N/A",null,"Q5RHS7",{"v":1.65128049382943,"d":"1.7"},{"v":16.9128438165901,"d":"16.9"},{"v":4.58248297361457,"d":"4.6"},{"v":5.6940792057109306e-05,"d":"0.0"},{"v":0.00178891910721014,"d":"0.0"},{"v":1.75528289585613,"d":"1.8"}]
["DNAJB11 ","DnaJ homolog subfamily B member 11","Q9UBS4;H7C2Y5",{"v":-1.19117456111242,"d":"-1.2"},{"v":13.8983819246695,"d":"13.9"},{"v":-4.54416638040804,"d":"-4.5"},{"v":6.38142231809718e-05,"d":"0.0"},{"v":0.00189442120284532,"d":"0.0"},{"v":1.6474785332800002,"d":"1.6"}]
["PROCR","Endothelial protein C receptor","A0A0U1RQQ4;Q9UNN8;A0A0U1RRC4",{"v":1.04117389121924,"d":"1.0"},{"v":16.7253708880129,"d":"16.7"},{"v":4.51609526106448,"d":"4.5"},{"v":6.93633788171013e-05,"d":"0.0"},{"v":0.00196558779963686,"d":"0.0"},{"v":1.56862843225434,"d":"1.6"}]
["LCP1","Plastin-2","P13796;Q5TBN3;P13796-2;Q5TBN5",{"v":1.2658581979907901,"d":"1.3"},{"v":20.4507803397475,"d":"20.5"},{"v":4.38539649642295,"d":"4.4"},{"v":0.000102134263006787,"d":"0.0"},{"v":0.00239445111120733,"d":"0.0"},{"v":1.20304381049529,"d":"1.2"}]
["JUN","Transcription factor AP-1","P05412",{"v":1.1879811785004901,"d":"1.2"},{"v":15.1831953990499,"d":"15.2"},{"v":4.19879147158851,"d":"4.2"},{"v":0.000176712500601166,"d":"0.0"},{"v":0.00328138107810868,"d":"0.0"},{"v":0.686046650564569,"d":"0.7"}]
["CGB","Choriogonadotropin subunit beta variant 1;Choriogonadotropin subunit beta variant 2","P0DN86;P0DN86-2;P0DN87;A6NKQ9-2;Q6NT52;A6NKQ9;K7ELM3;M0R0E6",{"v":1.5523052549873801,"d":"1.6"},{"v":15.4155834593281,"d":"15.4"},{"v":4.04214640087091,"d":"4.0"},{"v":0.000278741676472987,"d":"0.0"},{"v":0.00425105003500728,"d":"0.0"},{"v":0.257308050883791,"d":"0.3"}]
["HB?",null,"CON__P01966;G3V1N2;A0A2R8Y7C0;P69905;P02008",{"v":1.02062551236445,"d":"1.0"},{"v":15.9724979483331,"d":"16.0"},{"v":3.86748764483812,"d":"3.9"},{"v":0.000460758679462666,"d":"0.0"},{"v":0.00566439617577649,"d":"0.0"},{"v":-0.214156216314561,"d":"-0.2"}]
["TAGLN","Transgelin","Q01995;H0YCU9;E9PJ32",{"v":1.2316412642171999,"d":"1.2"},{"v":18.0948608218827,"d":"18.1"},{"v":3.7312860111384802,"d":"3.7"},{"v":0.000678692303336137,"d":"0.0"},{"v":0.00738244226030828,"d":"0.0"},{"v":-0.576355030109178,"d":"-0.6"}]
["CD44","CD44 antigen","P16070-18;P16070-12;P16070-14;P16070-13;P16070-11;P16070-10;P16070-16;P16070-8;P16070-17;P16070-6;P16070-4;P16070-3;P16070-7;P16070-5;P16070;H0YD13;H0Y2P0;H0YE40;H0YDW7;H0YCV9;H0Y5E4;P16070-15;P16070-9;H0YDX6;E9PKC6;H0YD17;J3KN83;Q86UZ1;P16070-19;H0YF08;H0YD90;H0YEV3;H0YEU1",{"v":1.09467470751218,"d":"1.1"},{"v":17.2974767449702,"d":"17.3"},{"v":3.67511225055133,"d":"3.7"},{"v":0.000795207664658825,"d":"0.0"},{"v":0.00822257177585173,"d":"0.0"},{"v":-0.72421027553228,"d":"-0.7"}]
["NXN","Nucleoredoxin","Q6DKJ4;A0A0G2JQK5;I3L4V6;Q6DKJ4-3;A0A0C4DGI2;Q6DKJ4-2",{"v":-1.3587486676915,"d":"-1.4"},{"v":13.0023789430419,"d":"13.0"},{"v":-3.66740621864045,"d":"-3.7"},{"v":0.000812629956258612,"d":"0.0"},{"v":0.00825274999056229,"d":"0.0"},{"v":-0.744420396255876,"d":"-0.7"}]
["CA9","Carbonic anhydrase 9","Q16790;A0A087WYS4",{"v":1.8034259364609602,"d":"1.8"},{"v":9.94180190318143,"d":"9.9"},{"v":3.60240511362582,"d":"3.6"},{"v":0.000975034637428392,"d":"0.0"},{"v":0.00945559747247686,"d":"0.0"},{"v":-0.914172615832138,"d":"-0.9"}]
["FLNA","Filamin-A","P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;H0Y5F3;H0Y5C6;H7C2E7",{"v":-1.56343653507069,"d":"-1.6"},{"v":19.4336119315063,"d":"19.4"},{"v":-3.50887714734743,"d":"-3.5"},{"v":0.00126475445803915,"d":"0.0"},{"v":0.0112937229069975,"d":"0.0"},{"v":-1.15606986630951,"d":"-1.2"}]
["CRABP2","Cellular retinoic acid-binding protein 2","P29373;Q5SYZ4",{"v":-1.3920821536228,"d":"-1.4"},{"v":15.9606891938136,"d":"16.0"},{"v":-3.4848094181002898,"d":"-3.5"},{"v":0.00135178848522029,"d":"0.0"},{"v":0.0117172603464993,"d":"0.0"},{"v":-1.21784970171034,"d":"-1.2"}]
[null,"??","CON__Q3SX09;CON__P02070;A0A2R8Y7R2;E9PFT6;P68871;P02042;A8MUF7;F8W6P5;E9PEW8;A0A2R8Y7X9;P69892;P69891;P02100",{"v":1.14989406496228,"d":"1.1"},{"v":17.8317681023989,"d":"17.8"},{"v":3.41118275860223,"d":"3.4"},{"v":0.00165527085170631,"d":"0.0"},{"v":0.013479067963069,"d":"0.0"},{"v":-1.40560292905974,"d":"-1.4"}]
["CTNNB1","Catenin beta-1","A0A2R8Y804;A0A2R8Y543;A0A2R8Y5C3;A0A2R8Y750;B4DGU4;A0A2R8YCH5;A0A2R8Y5A3;P35222;A0A2R8Y5Z1;A0A2R8Y7Z0;A0A2R8Y6G0;A0A2R8Y815;A0A2R8YG06",{"v":-1.17781176354075,"d":"-1.2"},{"v":15.2230781878714,"d":"15.2"},{"v":-2.80065124433925,"d":"-2.8"},{"v":0.00827247119106874,"d":"0.0"},{"v":0.0405671018187437,"d":"0.0"},{"v":-2.87909576260035,"d":"-2.9"}]

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["Supplementary table 5D. Differentially expressed Proteins (DEPs) in RKO KRAS G12D as compared to RKO BRAF WT."]
["Symbol","Name","Protein IDs","logFC","AveExpr","t","P","adjusted P","B"]
["LGALS1","Galectin-1","P09382;F8WEI7",{"v":1.3666395703877101,"d":"1.4"},{"v":19.392729724959,"d":"19.4"},{"v":6.29190071697747,"d":"6.3"},{"v":3.28390194114635e-07,"d":"0.0"},{"v":0.000728697840740376,"d":"0.0"},{"v":6.53676614695603,"d":"6.5"}]
[null,"??","CON__P01966;G3V1N2;A0A2R8Y7C0;P69905;P02008",{"v":1.1168728300356099,"d":"1.1"},{"v":15.9724979483331,"d":"16.0"},{"v":4.23220056591695,"d":"4.2"},{"v":0.000160255425752599,"d":"0.0"},{"v":0.0165398506858148,"d":"0.0"},{"v":0.879646476160381,"d":"0.9"}]
["S100A10","Protein S100-A10","P60903",{"v":1.24225341313556,"d":"1.2"},{"v":17.6293894507127,"d":"17.6"},{"v":4.13462542552484,"d":"4.1"},{"v":0.000213096735978255,"d":"0.0"},{"v":0.0193004758014591,"d":"0.0"},{"v":0.619674577191263,"d":"0.6"}]
["CD44","CD44 antigen","P16070-18;P16070-12;P16070-14;P16070-13;P16070-11;P16070-10;P16070-16;P16070-8;P16070-17;P16070-6;P16070-4;P16070-3;P16070-7;P16070-5;P16070;H0YD13;H0Y2P0;H0YE40;H0YDW7;H0YCV9;H0Y5E4;P16070-15;P16070-9;H0YDX6;E9PKC6;H0YD17;J3KN83;Q86UZ1;P16070-19;H0YF08;H0YD90;H0YEV3;H0YEU1",{"v":1.19134300957962,"d":"1.2"},{"v":17.2974767449702,"d":"17.3"},{"v":3.9996532842758,"d":"4.0"},{"v":0.00031517679213787,"d":"0.0"},{"v":0.022730330105858,"d":"0.0"},{"v":0.263079064456243,"d":"0.3"}]
[null,"??","CON__Q3SX09;CON__P02070;A0A2R8Y7R2;E9PFT6;P68871;P02042;A8MUF7;F8W6P5;E9PEW8;A0A2R8Y7X9;P69892;P69891;P02100",{"v":1.2812029387203099,"d":"1.3"},{"v":17.8317681023989,"d":"17.8"},{"v":3.80071304653321,"d":"3.8"},{"v":0.000557403377039423,"d":"0.0"},{"v":0.0305401998432217,"d":"0.0"},{"v":-0.255237341136583,"d":"-0.3"}]

{"sheet":"G12V_V600E","index":4,"n_rows":27,"n_cols":9,"rows_kept":27,"merged":[[27,0,27,8]],"flags":["formulas_cached_only"]}
["Supplementary table 5E. Differentially expressed Proteins (DEPs) in RKO KRAS G12V as compared to RKO BRAF V600E."]
["Symbol","Name","Protein IDs","logFC","AveExpr","t","P","adjusted P","B"]
["OCIAD2 ","OCIA domain-containing protein 2","Q56VL3;D6RD77;J3KPI9;Q56VL3-2",{"v":1.20002822358918,"d":"1.2"},{"v":17.0500138041342,"d":"17.1"},{"v":6.72737302250943,"d":"6.7"},{"v":8.90703583792478e-08,"d":"0.0"},{"v":5.64706072124431e-05,"d":"0.0"},{"v":7.86972477517837,"d":"7.9"}]
["SERPINE1 ","Plasminogen activator inhibitor 1","P05121;P05121-2",{"v":1.21946235115154,"d":"1.2"},{"v":16.0293424438735,"d":"16.0"},{"v":6.06005506405242,"d":"6.1"},{"v":6.60601216987603e-07,"d":"0.0"},{"v":0.000212293805700161,"d":"0.0"},{"v":5.98407048570451,"d":"6.0"}]
["ASNS ","Asparagine synthetase [glutamine-hydrolyzing]","P08243-2;P08243;P08243-3;F8WEJ5;C9J057;C9JT45;C9JM09;C9JLN6",{"v":-1.04160875994546,"d":"-1.0"},{"v":17.751751290921298,"d":"17.8"},{"v":-5.85644190858452,"d":"-5.9"},{"v":1.22247520322359e-06,"d":"0.0"},{"v":0.000319137938347428,"d":"0.0"},{"v":5.40396306146794,"d":"5.4"}]
["S100A2","Protein S100-A2","P29034;R4GN49",{"v":2.39187530302457,"d":"2.4"},{"v":18.3487726888154,"d":"18.3"},{"v":5.7379736325341195,"d":"5.7"},{"v":1.74969366097835e-06,"d":"0.0"},{"v":0.000388257023371095,"d":"0.0"},{"v":5.06590692736403,"d":"5.1"}]
["H1-0","Histone H1.0;Histone H1.0, N-terminally processed","P07305;P07305-2",{"v":-1.2160335838518601,"d":"-1.2"},{"v":17.6342627784821,"d":"17.6"},{"v":-5.69041684292824,"d":"-5.7"},{"v":2.02068338875153e-06,"d":"0.0"},{"v":0.000427037756156157,"d":"0.0"},{"v":4.9301340631018,"d":"4.9"}]
["TOP2A","DNA topoisomerase 2-alpha","P11388;P11388-2;P11388-3;P11388-4;J3KTB7",{"v":-1.14949527085485,"d":"-1.1"},{"v":17.6399082190929,"d":"17.6"},{"v":-5.64794325009555,"d":"-5.6"},{"v":2.29803942453805e-06,"d":"0.0"},{"v":0.000443421694178256,"d":"0.0"},{"v":4.80885365261385,"d":"4.8"}]
["S100A13","Protein S100-A13","Q99584",{"v":1.13946846294577,"d":"1.1"},{"v":17.2129103070602,"d":"17.2"},{"v":5.60913218801103,"d":"5.6"},{"v":2.58465992561041e-06,"d":"0.0"},{"v":0.000477946697910793,"d":"0.0"},{"v":4.69802149400509,"d":"4.7"}]
["UAP1","UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase","Q16222-3;Q16222;Q16222-2",{"v":1.28897693517531,"d":"1.3"},{"v":18.4517161957344,"d":"18.5"},{"v":5.48764732167781,"d":"5.5"},{"v":3.7340686612795303e-06,"d":"0.0"},{"v":0.000591849882812805,"d":"0.0"},{"v":4.35110385044129,"d":"4.4"}]
["S100A10","Protein S100-A10","P60903",{"v":1.59077068018292,"d":"1.6"},{"v":17.6293894507127,"d":"17.6"},{"v":5.42535548465854,"d":"5.4"},{"v":4.50911399828173e-06,"d":"0.0"},{"v":0.000661178566898142,"d":"0.0"},{"v":4.1732670799225104,"d":"4.2"}]
["DNAJB11","DnaJ homolog subfamily B member 11","Q9UBS4;H7C2Y5",{"v":-1.38473870335819,"d":"-1.4"},{"v":13.8983819246695,"d":"13.9"},{"v":-5.41304072730519,"d":"-5.4"},{"v":4.68038404745177e-06,"d":"0.0"},{"v":0.000661178566898142,"d":"0.0"},{"v":4.13811663957594,"d":"4.1"}]
["CRIP2 ","Cysteine-rich protein 2","P52943;H0YFA4;P52943-2;H0YHD8",{"v":1.14381436802549,"d":"1.1"},{"v":15.9902631358744,"d":"16.0"},{"v":5.3181389481481,"d":"5.3"},{"v":6.23746131578251e-06,"d":"0.0"},{"v":0.00078435096983984,"d":"0.0"},{"v":3.86734337919658,"d":"3.9"}]
[" GLRX","Glutaredoxin-1","P35754",{"v":1.83458734949552,"d":"1.8"},{"v":17.7214789096186,"d":"17.7"},{"v":5.01918514403069,"d":"5.0"},{"v":1.53845556332588e-05,"d":"0.0"},{"v":0.00142243037292505,"d":"0.0"},{"v":3.01654547696866,"d":"3.0"}]
["N/A",null,"Q5RHS7",{"v":1.76529940192694,"d":"1.8"},{"v":16.9128438165901,"d":"16.9"},{"v":5.01987650248744,"d":"5.0"},{"v":1.5352542580003202e-05,"d":"0.0"},{"v":0.00142243037292505,"d":"0.0"},{"v":3.01850757653023,"d":"3.0"}]
["SLC7A5","Large neutral amino acids transporter small subunit 1","Q01650;A0A0C4DGL4;H0YJ95;G3V4Z6;Q9UM01",{"v":-1.2522415111060101,"d":"-1.3"},{"v":15.9299493981437,"d":"15.9"},{"v":-4.99209092745501,"d":"-5.0"},{"v":1.66927682999349e-05,"d":"0.0"},{"v":0.00149677198935875,"d":"0.0"},{"v":2.93967623710168,"d":"2.9"}]
["JUN","Transcription factor AP-1","P05412",{"v":1.35205437435772,"d":"1.4"},{"v":15.1831953990499,"d":"15.2"},{"v":4.89670063163315,"d":"4.9"},{"v":2.2240980503226002e-05,"d":"0.0"},{"v":0.00173751058837918,"d":"0.0"},{"v":2.66946502721267,"d":"2.7"}]
["CRABP2","Cellular retinoic acid-binding protein 2","P29373;Q5SYZ4",{"v":-1.87026839096332,"d":"-1.9"},{"v":15.9606891938136,"d":"16.0"},{"v":-4.79747532234715,"d":"-4.8"},{"v":2.9956386911096304e-05,"d":"0.0"},{"v":0.00201434007744615,"d":"0.0"},{"v":2.38918420849385,"d":"2.4"}]
["LGALS1","Galectin-1","P09382;F8WEI7",{"v":1.0081083783801,"d":"1.0"},{"v":19.392729724959,"d":"19.4"},{"v":4.7558674658446805,"d":"4.8"},{"v":3.39328225805651e-05,"d":"0.0"},{"v":0.00217751399651152,"d":"0.0"},{"v":2.27192808062481,"d":"2.3"}]
["LCP1 ","Plastin-2","P13796;Q5TBN3;P13796-2;Q5TBN5",{"v":1.15460735119688,"d":"1.2"},{"v":20.4507803397475,"d":"20.5"},{"v":4.09876269254108,"d":"4.1"},{"v":0.000236528948099957,"d":"0.0"},{"v":0.00882113841737487,"d":"0.0"},{"v":0.450901546376002,"d":"0.5"}]
["FLNA","Filamin-A","P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;H0Y5F3;H0Y5C6;H7C2E7",{"v":-1.71231203815615,"d":"-1.7"},{"v":19.4336119315063,"d":"19.4"},{"v":-3.93790709579719,"d":"-3.9"},{"v":0.000376530707756784,"d":"0.0"},{"v":0.0116044672293376,"d":"0.0"},{"v":0.0171122149487601,"d":"0.0"}]
["MT2A ","Metallothionein-2;Metallothionein-1G","P02795;P13640-2;P13640;H3BSF1;H3BSP9;P80294;P04731",{"v":1.68658954891504,"d":"1.7"},{"v":17.652580771999,"d":"17.7"},{"v":3.92554525441727,"d":"3.9"},{"v":0.000390143483366114,"d":"0.0"},{"v":0.0117053896956886,"d":"0.0"},{"v":-0.0159758691221015,"d":"-0.0"}]
["IFI16","Gamma-interferon-inducible protein 16","Q16666-2;Q16666;Q16666-3;Q16666-6;A0A0A0MRB1;H3BM18;X6RHM1;H3BR88;H3BVE6;X6RHR0;Q6K0P9-6;Q6K0P9-5;Q6K0P9-4;Q6K0P9-3;Q6K0P9-2;Q6K0P9",{"v":1.31011746792062,"d":"1.3"},{"v":16.6366690937998,"d":"16.6"},{"v":3.75605560082595,"d":"3.8"},{"v":0.000632739857828577,"d":"0.0"},{"v":0.0165182322884896,"d":"0.0"},{"v":-0.465708598787997,"d":"-0.5"}]
["FOSL1","Fos-related antigen 1","P15407;E9PPX2;E9PKL5;P15407-2",{"v":1.13716971760361,"d":"1.1"},{"v":15.9224175436383,"d":"15.9"},{"v":3.63057751585825,"d":"3.6"},{"v":0.000901123305533684,"d":"0.0"},{"v":0.0211597102114206,"d":"0.0"},{"v":-0.793555212533107,"d":"-0.8"}]
["TMSB4X ","Thymosin beta-4;Hematopoietic system regulatory peptide","P62328;CON__P21752;O14604",{"v":1.21073151234433,"d":"1.2"},{"v":16.7118098604205,"d":"16.7"},{"v":3.50621468800832,"d":"3.5"},{"v":0.00127411041538694,"d":"0.0"},{"v":0.0257522000054162,"d":"0.0"},{"v":-1.11374785386786,"d":"-1.1"}]
["MT1E ","Metallothionein-1E;Metallothionein-1M","P04732;CON__P67983;Q8N339;H3BU80;Q93083;P07438;P04732-2",{"v":1.38775561754528,"d":"1.4"},{"v":15.044090159441,"d":"15.0"},{"v":3.41253048934023,"d":"3.4"},{"v":0.00164916941452379,"d":"0.0"},{"v":0.0304958910902357,"d":"0.0"},{"v":-1.35158311190325,"d":"-1.4"}]
["NXN","Nucleoredoxin","Q6DKJ4;A0A0G2JQK5;I3L4V6;Q6DKJ4-3;A0A0C4DGI2;Q6DKJ4-2",{"v":-1.20638514396394,"d":"-1.2"},{"v":13.0023789430419,"d":"13.0"},{"v":-3.3365721140141,"d":"-3.3"},{"v":0.00202897566495735,"d":"0.0"},{"v":0.0350373307435048,"d":"0.0"},{"v":-1.54215147921786,"d":"-1.5"}]

{"sheet":"G12V_WT","index":5,"n_rows":3,"n_cols":9,"rows_kept":3,"merged":[[3,0,3,8]],"flags":["formulas_cached_only"]}
["Supplementary table 5F. Differentially expressed Proteins (DEPs) in RKO KRAS G12V as compared to RKO BRAF WT."]
["Symbol","Name","Protein IDs","logFC","AveExpr","t","P","adjusted P","B"]
["GLRX","Glutaredoxin-1","P35754",{"v":1.50510820337617,"d":"1.5"},{"v":17.7214789096186,"d":"17.7"},{"v":4.11777435215704,"d":"4.1"},{"v":0.000223809370111637,"d":"0.0"},{"v":0.0373444125352186,"d":"0.0"},{"v":0.586103041843476,"d":"0.6"}]

{"sheet":"G13D_V600E","index":6,"n_rows":34,"n_cols":9,"rows_kept":34,"merged":[[0,0,0,8],[34,0,34,8]],"flags":["formulas_cached_only"]}
["Supplementary table 5G:  Differentially expressed proteins between RKO KRAS G13D and RKO BRAF V600E."]
["Symbol","Name","Protein IDs","logFC","AveExpr","t","P","adjusted P","B"]
["PHGDH ","D-3-phosphoglycerate dehydrogenase","A0A286YF22;O43175;A0A2C9F2M7;A0A286YFA2;A0A286YFL2;A0A286YFM8;A0A286YF78;A0A286YER3;A0A286YFC8;A0A286YFB2;A0A286YF34;A0A286YFF3;A0A286YFE1;A0A286YFK5",{"v":-1.00981913882242,"d":"-1.0"},{"v":18.3642861481892,"d":"18.4"},{"v":-8.33332744120693,"d":"-8.3"},{"v":8.38318193347037e-10,"d":"0.0"},{"v":3.72045614207415e-06,"d":"0.0"},{"v":12.2586750491394,"d":"12.3"}]
["PSAT1","Phosphoserine aminotransferase","Q9Y617;Q9Y617-2",{"v":-1.12047724123602,"d":"-1.1"},{"v":17.4948420149628,"d":"17.5"},{"v":-6.98398293427426,"d":"-7.0"},{"v":4.15520372289521e-08,"d":"0.0"},{"v":2.8177645342174303e-05,"d":"0.0"},{"v":8.59938074932478,"d":"8.6"}]
["AHNAK2","Protein AHNAK2","Q8IVF2-3;Q8IVF2;Q8IVF2-2",{"v":1.47258489981111,"d":"1.5"},{"v":16.6556843742877,"d":"16.7"},{"v":6.77831388266844,"d":"6.8"},{"v":7.6527156240638e-08,"d":"0.0"},{"v":4.24534399244939e-05,"d":"0.0"},{"v":8.02362207866816,"d":"8.0"}]
["S100A10","Protein S100-A10","P60903",{"v":1.9770904864991499,"d":"2.0"},{"v":17.6293894507127,"d":"17.6"},{"v":6.58040340851987,"d":"6.6"},{"v":1.3815814380777099e-07,"d":"0.0"},{"v":6.81273158020986e-05,"d":"0.0"},{"v":7.4660675259213605,"d":"7.5"}]
["ASNS","Asparagine synthetase [glutamine-hydrolyzing]","P08243-2;P08243;P08243-3;F8WEJ5;C9J057;C9JT45;C9JM09;C9JLN6",{"v":-1.14416640365269,"d":"-1.1"},{"v":17.751751290921298,"d":"17.8"},{"v":-6.27803536679966,"d":"-6.3"},{"v":3.42383768952562e-07,"d":"0.0"},{"v":0.000123541927188885,"d":"0.0"},{"v":6.608591323236,"d":"6.6"}]
["CTSZ","Cathepsin Z","Q9UBR2",{"v":1.12391414670411,"d":"1.1"},{"v":15.9865622380133,"d":"16.0"},{"v":6.23776309625957,"d":"6.2"},{"v":3.86523283564239e-07,"d":"0.0"},{"v":0.000123541927188885,"d":"0.0"},{"v":6.49394856881942,"d":"6.5"}]
[" LGALS1","Galectin-1","P09382;F8WEI7",{"v":1.3303658521952,"d":"1.3"},{"v":19.392729724959,"d":"19.4"},{"v":6.12489938140355,"d":"6.1"},{"v":5.4317374524535e-07,"d":"0.0"},{"v":0.000150662817587429,"d":"0.0"},{"v":6.17220562061657,"d":"6.2"}]
["ASMTL","N-acetylserotonin O-methyltransferase-like protein","O95671-3;O95671-2;O95671",{"v":-1.06992135869255,"d":"-1.1"},{"v":15.4924467181638,"d":"15.5"},{"v":-5.9621951385628,"d":"-6.0"},{"v":8.878554185986609e-07,"d":"0.0"},{"v":0.000207384334091624,"d":"0.0"},{"v":5.70738014482209,"d":"5.7"}]
["SERPINE1","Plasminogen activator inhibitor 1","P05121;P05121-2",{"v":1.19958232006244,"d":"1.2"},{"v":16.0293424438735,"d":"16.0"},{"v":5.81759629203059,"d":"5.8"},{"v":1.3749571723989398e-06,"d":"0.0"},{"v":0.000285949899399321,"d":"0.0"},{"v":5.29353758227402,"d":"5.3"}]
["CD63","Tetraspanin;CD63 antigen","F8VNT9;F8VV56;F8W022;F8VWK8;P08962-3;P08962-2;P08962",{"v":1.01275090825159,"d":"1.0"},{"v":16.0121484673804,"d":"16.0"},{"v":5.5896811735429,"d":"5.6"},{"v":2.74149054592311e-06,"d":"0.0"},{"v":0.000467911352706744,"d":"0.0"},{"v":4.64048862316179,"d":"4.6"}]
["ITGB1","Integrin beta-1","P05556;P05556-2;P05556-5;P05556-4;P05556-3;E7EQW5;C9JPK5;Q5T3E6;E9PLR6;E7EUI6;E7ERX5;C9JJP8;Q5T3E5;E9PQJ2;H7C4N8;C9JNE0",{"v":1.04922888842315,"d":"1.0"},{"v":20.0830362216108,"d":"20.1"},{"v":5.58944123509675,"d":"5.6"},{"v":2.74348340193589e-06,"d":"0.0"},{"v":0.000467911352706744,"d":"0.0"},{"v":4.63980095525168,"d":"4.6"}]
["CRIP2","Cysteine-rich protein 2","P52943;H0YFA4;P52943-2;H0YHD8",{"v":1.24010380267103,"d":"1.2"},{"v":15.9902631358744,"d":"16.0"},{"v":5.62687829889889,"d":"5.6"},{"v":2.44941690750383e-06,"d":"0.0"},{"v":0.000467911352706744,"d":"0.0"},{"v":4.74709629232665,"d":"4.7"}]
["CPT1A","Carnitine O-palmitoyltransferase 1, liver isoform","P50416-2;P50416;H3BMD2;H3BUJ0;H3BP22;H3BUV7",{"v":-1.04456686874404,"d":"-1.0"},{"v":15.9905975898086,"d":"16.0"},{"v":-5.40765046365839,"d":"-5.4"},{"v":4.75737918785088e-06,"d":"0.0"},{"v":0.000611814292904169,"d":"0.0"},{"v":4.11891025386121,"d":"4.1"}]
["DNAJB11","DnaJ homolog subfamily B member 11","Q9UBS4;H7C2Y5",{"v":-1.4116924357534,"d":"-1.4"},{"v":13.8983819246695,"d":"13.9"},{"v":-5.3854116058658,"d":"-5.4"},{"v":5.0886391863141505e-06,"d":"0.0"},{"v":0.000627316130801727,"d":"0.0"},{"v":4.05522201183137,"d":"4.1"}]
["S100A2","Protein S100-A2","P29034;R4GN49",{"v":2.13232601547667,"d":"2.1"},{"v":18.3487726888154,"d":"18.3"},{"v":4.99205049540131,"d":"5.0"},{"v":1.66948008407415e-05,"d":"0.0"},{"v":0.00137206529872613,"d":"0.0"},{"v":2.93175393848112,"d":"2.9"}]
["FASTKD5","FAST kinase domain-containing protein 5","Q7L8L6",{"v":1.02774568894901,"d":"1.0"},{"v":15.0250222810828,"d":"15.0"},{"v":4.96747218737839,"d":"5.0"},{"v":1.79769839790311e-05,"d":"0.0"},{"v":0.00142764415592465,"d":"0.0"},{"v":2.8618398575637,"d":"2.9"}]
["CRABP2","Cellular retinoic acid-binding protein 2","P29373;Q5SYZ4",{"v":-1.8646896885320001,"d":"-1.9"},{"v":15.9606891938136,"d":"16.0"},{"v":-4.66789131052357,"d":"-4.7"},{"v":4.41417565233494e-05,"d":"0.0"},{"v":0.00225173695920258,"d":"0.0"},{"v":2.0138811553619,"d":"2.0"}]
["JUN","Transcription factor AP-1","P05412",{"v":1.28195488901982,"d":"1.3"},{"v":15.1831953990499,"d":"15.2"},{"v":4.53093142584278,"d":"4.5"},{"v":6.63737125884792e-05,"d":"0.0"},{"v":0.00279817083013115,"d":"0.0"},{"v":1.62947542807792,"d":"1.6"}]
["LCP1","Plastin-2","P13796;Q5TBN3;P13796-2;Q5TBN5",{"v":1.2936192677461,"d":"1.3"},{"v":20.4507803397475,"d":"20.5"},{"v":4.48157101125812,"d":"4.5"},{"v":7.684419169424359e-05,"d":"0.0"},{"v":0.0030449510958844,"d":"0.0"},{"v":1.49154962210517,"d":"1.5"}]
["FLNA","Filamin-A","P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;H0Y5F3;H0Y5C6;H7C2E7",{"v":-1.9568151243482,"d":"-2.0"},{"v":19.4336119315063,"d":"19.4"},{"v":-4.391750939285,"d":"-4.4"},{"v":0.000100236110542795,"d":"0.0"},{"v":0.00383489533266312,"d":"0.0"},{"v":1.24149641842418,"d":"1.2"}]
["UAP1","UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase","Q16222-3;Q16222;Q16222-2",{"v":1.03829375901365,"d":"1.0"},{"v":18.4517161957344,"d":"18.5"},{"v":4.31386589743769,"d":"4.3"},{"v":0.000126098873685998,"d":"0.0"},{"v":0.00458710492965951,"d":"0.0"},{"v":1.02571703651335,"d":"1.0"}]
["MT1E","Metallothionein-1E;Metallothionein-1M","P04732;CON__P67983;Q8N339;H3BU80;Q93083;P07438;P04732-2",{"v":1.7515467084693799,"d":"1.8"},{"v":15.044090159441,"d":"15.0"},{"v":4.20330224621201,"d":"4.2"},{"v":0.000174397353525274,"d":"0.0"},{"v":0.00544224099198175,"d":"0.0"},{"v":0.721238365770573,"d":"0.7"}]
["TAGLN","Transgelin","Q01995;H0YCU9;E9PJ32",{"v":1.39404982712155,"d":"1.4"},{"v":18.0948608218827,"d":"18.1"},{"v":4.22330655028407,"d":"4.2"},{"v":0.000164483584690067,"d":"0.0"},{"v":0.00544224099198175,"d":"0.0"},{"v":0.776159183343099,"d":"0.8"}]
["N/A",null,"Q5RHS7",{"v":1.51417613436349,"d":"1.5"},{"v":16.9128438165901,"d":"16.9"},{"v":4.20200346379854,"d":"4.2"},{"v":0.000175060885197662,"d":"0.0"},{"v":0.00544224099198175,"d":"0.0"},{"v":0.717675289967586,"d":"0.7"}]
["HMGA1","High mobility group protein HMG-I/HMG-Y","P17096-2",{"v":1.00782187362248,"d":"1.0"},{"v":15.0437856271966,"d":"15.0"},{"v":4.11409473595141,"d":"4.1"},{"v":0.000226217779839892,"d":"0.0"},{"v":0.00623574227906486,"d":"0.0"},{"v":0.477288371952333,"d":"0.5"}]
["GLRN","Glutaredoxin-1","P35754",{"v":1.5079002914125401,"d":"1.5"},{"v":17.7214789096186,"d":"17.7"},{"v":4.02599097535916,"d":"4.0"},{"v":0.000292081406478339,"d":"0.0"},{"v":0.00712029200598997,"d":"0.0"},{"v":0.237998169885116,"d":"0.2"}]
["MT1E","Metallothionein-2;Metallothionein-1G","P02795;P13640-2;P13640;H3BSF1;H3BSP9;P80294;P04731",{"v":1.74134371933238,"d":"1.7"},{"v":17.652580771999,"d":"17.7"},{"v":3.95530918506813,"d":"4.0"},{"v":0.00035814938399264,"d":"0.0"},{"v":0.00796206945383747,"d":"0.0"},{"v":0.0472925841984688,"d":"0.0"}]
["NXN","Nucleoredoxin","Q6DKJ4;A0A0G2JQK5;I3L4V6;Q6DKJ4-3;A0A0C4DGI2;Q6DKJ4-2",{"v":-1.41809736606035,"d":"-1.4"},{"v":13.0023789430419,"d":"13.0"},{"v":-3.82759462628462,"d":"-3.8"},{"v":0.000516334742882671,"d":"0.0"},{"v":0.0101817258678862,"d":"0.0"},{"v":-0.294198766807971,"d":"-0.3"}]
["FOSL1","Fos-related antigen 1","P15407;E9PPX2;E9PKL5;P15407-2",{"v":1.16079876086275,"d":"1.2"},{"v":15.9224175436383,"d":"15.9"},{"v":3.61670189703646,"d":"3.6"},{"v":0.000936823221397768,"d":"0.0"},{"v":0.0143862334137138,"d":"0.0"},{"v":-0.848398971574611,"d":"-0.8"}]
["TMSB4X","Thymosin beta-4;Hematopoietic system regulatory peptide","P62328;CON__P21752;O14604",{"v":1.23121184954103,"d":"1.2"},{"v":16.7118098604205,"d":"16.7"},{"v":3.4795957814424,"d":"3.5"},{"v":0.00137138741090561,"d":"0.0"},{"v":0.0190194291549972,"d":"0.0"},{"v":-1.20142622692921,"d":"-1.2"}]
["CTNNB1","Catenin beta-1","A0A2R8Y804;A0A2R8Y543;A0A2R8Y5C3;A0A2R8Y750;B4DGU4;A0A2R8YCH5;A0A2R8Y5A3;P35222;A0A2R8Y5Z1;A0A2R8Y7Z0;A0A2R8Y6G0;A0A2R8Y815;A0A2R8YG06",{"v":-1.41984870863985,"d":"-1.4"},{"v":15.2230781878714,"d":"15.2"},{"v":-3.37617705623135,"d":"-3.4"},{"v":0.00182155132151131,"d":"0.0"},{"v":0.0228362846465175,"d":"0.0"},{"v":-1.46351662863196,"d":"-1.5"}]
["FTH1","Ferritin;Ferritin heavy chain;Ferritin heavy chain, N-terminally processed","G3V192;P02794;G3V1D1;E9PPQ4;E9PRK8;E9PKY7",{"v":-1.12038383640304,"d":"-1.1"},{"v":14.5794202571385,"d":"14.6"},{"v":-3.26620121145922,"d":"-3.3"},{"v":0.00245447468914023,"d":"0.0"},{"v":0.0275352402414885,"d":"0.0"},{"v":-1.73795695768423,"d":"-1.7"}]

{"sheet":"G13D_WT","index":7,"n_rows":4,"n_cols":9,"rows_kept":4,"merged":[[4,0,4,8]],"flags":["formulas_cached_only"]}
["Supplementary table 5H: Differentially expressed Proteins (DEPs) in RKO KRAS G13D as compared to RKO BRAF WT."]
["Symbol","Name","Protein IDs","logFC","AveExpr","t","P","adjusted P","B"]
["AHNAK2","Protein AHNAK2","Q8IVF2-3;Q8IVF2;Q8IVF2-2",{"v":1.24032466892868,"d":"1.2"},{"v":16.6556843742877,"d":"16.7"},{"v":5.70921915842938,"d":"5.7"},{"v":1.9088524836786997e-06,"d":"0.0"},{"v":0.00328067107014549,"d":"0.0"},{"v":4.88292363239636,"d":"4.9"}]
["LGALS1","Galectin-1","P09382;F8WEI7",{"v":1.04566818518297,"d":"1.0"},{"v":19.392729724959,"d":"19.4"},{"v":4.81417379287994,"d":"4.8"},{"v":2.84936013465449e-05,"d":"0.0"},{"v":0.0105070930026822,"d":"0.0"},{"v":2.44511891302649,"d":"2.4"}]

{"sheet":"MHB32_HCT116_DEP_filtered","index":8,"n_rows":4,"n_cols":8,"rows_kept":4,"merged":[[4,0,4,7]],"flags":["formulas_cached_only"]}
["Supplementary table 5I:  Differentially expressed Proteins (DEPs) in HCT116 BRAF V600E as compared to HCT116 KRAS G13D ."]
["Protein.names","Proteins.IDs","logFC","AveExpr","t","P.Value","adj.P.Val","B"]
["NAD(P)H dehydrogenase [quinone] 1","P15559-2;P15559;B4DLR8;P15559-3;H3BNV2;H3BRK3",{"v":1.03471830777079,"d":"1.0"},{"v":17.7934850452227,"d":"17.8"},{"v":5.22159615968837,"d":"5.2"},{"v":8.35196793185174e-06,"d":"0.0"},{"v":0.018533016840779,"d":"0.0"},{"v":3.38245102922671,"d":"3.4"}]
["Keratin, type II cytoskeletal 7","CON__P08729;CON__Q3KNV1;P08729;CON__Q9DCV7;A0A1W2PRP1;CON__Q14CN4-1;CON__Q6IME9;Q14CN4-3;Q14CN4-2;Q14CN4",{"v":2.69466798108324,"d":"2.7"},{"v":17.5676404458425,"d":"17.6"},{"v":4.5584098736789205,"d":"4.6"},{"v":6.11684553032496e-05,"d":"0.0"},{"v":0.0452442674393037,"d":"0.0"},{"v":1.67117635144665,"d":"1.7"}]