{"text_format":"3","workbook":"xlsx","n_sheets":6,"sheets":["HCT116_Allproteins_3DsiKvssiC","HCT116_Signproteins_3DsiKvssiC","SW480_Allproteins_3DsiKvssiC","SW480_Signproteins_3DsiKvssiC","LS174T_Allproteins_3DsiKvssiC","LS174T_Signproteins_3DsiKvssiC"],"not_rendered":{"defined_names":6},"read":"whole","date_system":"1900"}

{"sheet":"HCT116_Allproteins_3DsiKvssiC","index":0,"n_rows":4645,"n_cols":38,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["3D siKRAS 3","3D siKRAS 1","3D siKRAS 2","3D NT 3","3D NT 1","3D NT 2","C: Only identified by site","C: Reverse","C: Potential contaminant","C: GOBP name","C: GOMF name","C: GOCC name","C: KEGG pathway name","C: Student's T-test Significant 3D siKRAS_3D NT","C: Student's T-test significant","N: Peptides","N: Razor + unique peptides","N: Unique peptides","N: Sequence coverage [%]","N: Unique + razor sequence coverage [%]","N: Unique sequence coverage [%]","N: Mol. weight [kDa]","N: Q-value","N: Score","N: Intensity","N: MS/MS Count","N: -Log Student's T-test p-value 3D siKRAS_3D NT","N: Student's T-test q-value 3D siKRAS_3D NT","N: Student's T-test Difference 3D siKRAS_3D NT","N: Student's T-test Test statistic 3D siKRAS_3D NT","T: Protein IDs","T: Majority protein IDs","T: id","T: Uniprot IDs","T: Uniprot name","T: Uniprot full protein name","T: Uniprot short protein name","T: Gene name"]
["22.4858","21.2949","20.7507",1,1,1,{"$nulls":3},"ATP biosynthetic process;cristae formation;mitochondrial ATP synthesis coupled proton transport;proton transport","transmembrane transporter activity","extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);mitochondrion;nucleoplasm;nucleus","Metabolic pathways;Oxidative phosphorylation;Thermogenesis",null,null,3,1,1,"39.4","13.8","13.8","10.918","0.0010079","3.6725",168510000,10,"5.63332",1,"20.5105","40.0328","sp|P56134|ATPK_HUMAN;tr|C9JU26|C9JU26_HUMAN","sp|P56134|ATPK_HUMAN;tr|C9JU26|C9JU26_HUMAN",1859,"P56134","ATPK_HUMAN","ATP synthase subunit f, mitochondrial",null,"ATP5J2"]
["18.9633","16.7211","18.1094",1,1,1,{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;humoral immune response;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;nucleoplasm;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex;spermatoproteasome complex","Proteasome",null,null,2,2,2,"9.9","9.9","9.9","28.936","0.001006","3.6442",20866000,5,"4.88026",1,"16.9312","25.9136","sp|P40306|PSB10_HUMAN;tr|J3QQN1|J3QQN1_HUMAN","sp|P40306|PSB10_HUMAN;tr|J3QQN1|J3QQN1_HUMAN",1516,"P40306","PSB10_HUMAN","Proteasome subunit beta type-10",null,"PSMB10"]
["16.8285","17.3978","16.1037",1,1,1,{"$nulls":3},"ribosomal large subunit assembly","RNA binding;rRNA binding","nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},5,5,5,"18.2","18.2","18.2","53.193",0,"33.09",66090000,13,"5.72177",1,"15.7767","42.1282","sp|Q9NQ55|SSF1_HUMAN;tr|A0A0A6YYI3|A0A0A6YYI3_HUMAN;tr|A0A0B4J1V8|A0A0B4J1V8_HUMAN;tr|A8MV53|A8MV53_HUMAN;tr|H7C446|H7C446_HUMAN;tr|C9J3W3|C9J3W3_HUMAN","sp|Q9NQ55|SSF1_HUMAN;tr|A0A0A6YYI3|A0A0A6YYI3_HUMAN;tr|A0A0B4J1V8|A0A0B4J1V8_HUMAN;tr|A8MV53|A8MV53_HUMAN;tr|H7C446|H7C446_HUMAN",4651,"Q9NQ55","SSF1_HUMAN","Suppressor of SWI4 1 homolog","sf-1","PPAN"]
["17.3073","15.0323","17.3852",1,1,1,{"$nulls":3},"negative regulation of peptidyl-lysine crotonylation;random inactivation of X chromosome;regulation of transcription, DNA-templated;spermatid development;spermatogenesis;transcription, DNA-templated","chromatin binding;crotonyl-CoA hydratase activity;methylated histone binding;protein binding, bridging;transcription corepressor activity","chromosome;nuclear body;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"4.7","4.7","4.7","66.481",0,"7.6303",23179000,7,"4.44894",1,"15.5749","20.1838","sp|Q9Y232|CDYL1_HUMAN;tr|C9JQG7|C9JQG7_HUMAN","sp|Q9Y232|CDYL1_HUMAN;tr|C9JQG7|C9JQG7_HUMAN",5199,"Q9Y232","CDYL_HUMAN","Chromodomain Y-like protein {ECO:0000303|PubMed:10192397}","DY-like {ECO:0000303|PubMed:10192397}","CDYL"]
["18.3204","13.47","17.3354",1,1,1,{"$nulls":3},"DNA recombination;DNA repair;forebrain morphogenesis;lateral ventricle development;midbrain development;protein deubiquitination;regulation of proteasomal protein catabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated;ubiquitin-dependent protein catabolic process","endopeptidase inhibitor activity;proteasome binding;RNA binding;thiol-dependent ubiquitin-specific protease activity","cytosol;cytosolic proteasome complex;Ino80 complex;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},15,1,1,"55.6","7.9","7.9","37.606","0.00042017","4.4894",20651000,2,"3.31424",1,"15.3753","10.3873","sp|Q9Y5K5|UCHL5_HUMAN;tr|Q5LJA9|Q5LJA9_HUMAN;tr|H0Y6Y4|H0Y6Y4_HUMAN;tr|H0Y4E0|H0Y4E0_HUMAN","sp|Q9Y5K5|UCHL5_HUMAN;tr|Q5LJA9|Q5LJA9_HUMAN;tr|H0Y6Y4|H0Y6Y4_HUMAN;tr|H0Y4E0|H0Y4E0_HUMAN",5354,"Q9Y5K5","UCHL5_HUMAN","Ubiquitin carboxyl-terminal hydrolase isozyme L5","CH-L5","UCHL5"]
["16.8943","15.046","16.6907",1,1,1,{"$nulls":3},"cardiac right ventricle formation;chromatin remodeling;covalent chromatin modification;muscle cell differentiation;neural retina development;nucleosome disassembly;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of neuroblast proliferation;positive regulation of smooth muscle cell differentiation;positive regulation of transcription, DNA-templated;regulation of lipid metabolic process;regulation of protein binding;regulation of transcription from RNA polymerase II promoter;secondary heart field specification;transcription, DNA-templated","chromatin binding;ligand-dependent nuclear receptor binding;ligand-dependent nuclear receptor transcription coactivator activity;nuclear hormone receptor binding;receptor binding;transcription coactivator activity;transcription factor binding","cytoplasm;nBAF complex;npBAF complex;nuclear chromatin;nucleoplasm;nucleus;SWI/SNF complex","Hepatocellular carcinoma;Thermogenesis",null,null,9,3,3,"20.3","7.9","7.9","55.015","0.00042535","4.77",44179000,0,"4.88571",1,"15.2103","25.9954","sp|Q6STE5|SMRD3_HUMAN","sp|Q6STE5|SMRD3_HUMAN",3050,"Q6STE5","SMRD3_HUMAN","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3",null,"SMARCD3"]
["15.5509","15.868","15.7321",1,1,1,{"$nulls":3},"activation of GTPase activity;intracellular protein transport;regulation of vesicle fusion","14-3-3 protein binding;GTPase activator activity;Rab GTPase binding","endomembrane system;intracellular",{"$nulls":3},1,1,1,"2.6","2.6","2.6","59.08","0.0011816","3.3252",12811000,2,"8.04107",1,"14.717","160.243","sp|Q9NU19|TB22B_HUMAN","sp|Q9NU19|TB22B_HUMAN",4726,"Q9NU19","TB22B_HUMAN","TBC1 domain family member 22B",null,"TBC1D22B"]
["16.106","13.7311","16.892",1,1,1,{"$nulls":4},"metal ion binding;RNA binding","nuclear speck;protein complex",{"$nulls":3},6,6,6,"11.1","11.1","11.1","106.38",0,"17.276",53208000,14,"3.97752",1,"14.5764","15.3415","sp|Q86VM9|ZCH18_HUMAN;tr|E7ERS3|E7ERS3_HUMAN;tr|H3BRH3|H3BRH3_HUMAN","sp|Q86VM9|ZCH18_HUMAN;tr|E7ERS3|E7ERS3_HUMAN",3231,"Q86VM9","ZCH18_HUMAN","Zinc finger CCCH domain-containing protein 18",null,"ZC3H18"]
["22.1941","18.8217","18.9338",1,"14.851",1,{"$nulls":5},"endosome;mitochondrial inner membrane",{"$nulls":3},5,5,5,"32.5","32.5","32.5","16.953",0,"21.611",84429000,11,"1.40967",1,"14.3662","3.02598","sp|Q56VL3|OCAD2_HUMAN;tr|D6RD77|D6RD77_HUMAN;tr|J3KPI9|J3KPI9_HUMAN","sp|Q56VL3|OCAD2_HUMAN",2796,"Q56VL3","OCAD2_HUMAN","OCIA domain-containing protein 2",null,"OCIAD2"]
["19.6269","21.4267","17.4532",1,"14.9105",1,{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of cysteine-type endopeptidase activity;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;nucleoplasm;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex;spermatoproteasome complex","Proteasome",null,null,4,4,4,"24.2","24.2","24.2","23.264",0,"9.2192",65397000,5,"1.35649",1,"13.8655","2.90255","sp|P28065|PSB9_HUMAN;tr|A2ACR1|A2ACR1_HUMAN;tr|A0A0G2JJA7|A0A0G2JJA7_HUMAN;tr|A2ACR0|A2ACR0_HUMAN;tr|A0A0G2JJQ0|A0A0G2JJQ0_HUMAN;tr|A0A0G2JJ13|A0A0G2JJ13_HUMAN;tr|A0A0G2JHI2|A0A0G2JHI2_HUMAN","sp|P28065|PSB9_HUMAN;tr|A2ACR1|A2ACR1_HUMAN;tr|A0A0G2JJA7|A0A0G2JJA7_HUMAN",1332,"P28065","PSB9_HUMAN","Proteasome subunit beta type-9",null,"PSMB9"]
["21.348","18.2936","20.3694",1,1,"18.393",{"$nulls":3},"positive regulation of epithelial cell migration;positive regulation of epithelial to mesenchymal transition;positive regulation of ERK1 and ERK2 cascade","protein homodimerization activity","extracellular exosome;Golgi membrane",{"$nulls":3},4,4,4,"35.1","35.1","35.1","17.218",0,"24.783",103800000,12,"1.05767",1,"13.206","2.25083","sp|Q9H4G4|GAPR1_HUMAN;tr|Q5VZR0|Q5VZR0_HUMAN;tr|A0A087WUM5|A0A087WUM5_HUMAN","sp|Q9H4G4|GAPR1_HUMAN;tr|Q5VZR0|Q5VZR0_HUMAN",4466,"Q9H4G4","GAPR1_HUMAN","Golgi-associated plant pathogenesis-related protein 1","APR-1;olgi-associated PR-1 protein","GLIPR2"]
["22.1299","19.3224","20.6759","21.092",1,1,{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"19.2","19.2","19.2","17.056",0,"7.8086",50006000,4,"0.899662",1,"13.0121","1.92879","tr|M0R3D4|M0R3D4_HUMAN;sp|Q9UI14|PRAF1_HUMAN;tr|M0QXH1|M0QXH1_HUMAN;tr|M0R1H9|M0R1H9_HUMAN","tr|M0R3D4|M0R3D4_HUMAN;sp|Q9UI14|PRAF1_HUMAN;tr|M0QXH1|M0QXH1_HUMAN;tr|M0R1H9|M0R1H9_HUMAN",5042,"M0R3D4","M0R3D4_HUMAN","PRA1 family protein {ECO:0000256|RuleBase:RU363107}"]
["20.6886","19.9579","18.45",1,"18.5824",1,{"$nulls":3},"mRNA splicing, via spliceosome;RNA metabolic process","RNA binding","cytosol;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus",{"$nulls":3},12,6,6,"39.2","22.3","22.3","49.263",0,"36.416",118320000,10,"1.02188",1,"12.838","2.17678","sp|P55795|HNRH2_HUMAN","sp|P55795|HNRH2_HUMAN",1854,"P55795","HNRH2_HUMAN","Heterogeneous nuclear ribonucleoprotein H2","nRNP H2","HNRNPH2"]
["18.2337","18.4712","18.553",1,1,"15.6958",{"$nulls":3},"cellular response to interferon-alpha;defense response to virus;negative regulation of apoptotic process;negative regulation of cell proliferation;response to virus;type I interferon signaling pathway","identical protein binding","cytoplasm;cytosol;mitochondrion",{"$nulls":3},4,4,4,11,11,11,"55.984",0,"9.6095",33038000,5,"1.20109",1,"12.5207","2.5555","sp|O14879|IFIT3_HUMAN","sp|O14879|IFIT3_HUMAN",302,"O14879","IFIT3_HUMAN","Interferon-induced protein with tetratricopeptide repeats 3","FIT-3","IFIT3"]
["18.8438","15.4956","19.4089",1,"14.7591",1,{"$nulls":3},"cellular response to exogenous dsRNA;cellular response to type I interferon;defense response to virus;intracellular transport of viral protein in host cell;negative regulation of defense response to virus by host;negative regulation of helicase activity;negative regulation of protein binding;negative regulation of viral genome replication;positive regulation of viral genome replication;response to virus;type I interferon signaling pathway;viral process","RNA binding","cytoplasm;cytosol;host cell","Hepatitis C",null,null,5,5,4,"13.4","13.4","11.3","55.36",0,"19.257",88617000,6,"1.22051",1,"12.3297","2.59784","sp|P09914|IFIT1_HUMAN","sp|P09914|IFIT1_HUMAN",1002,"P09914","IFIT1_HUMAN","Interferon-induced protein with tetratricopeptide repeats 1","FIT-1","IFIT1"]
["19.3425","16.7758","18.2615",1,"15.4742",1,{"$nulls":3},"metabolic process","catalytic activity",{"$nulls":4},6,6,6,"19.8","19.8","19.8","63.652",0,"16.502",45898000,9,"1.18469",1,"12.3019","2.51997","tr|E9PF16|E9PF16_HUMAN;sp|Q96CM8|ACSF2_HUMAN;tr|D6RF87|D6RF87_HUMAN","tr|E9PF16|E9PF16_HUMAN;sp|Q96CM8|ACSF2_HUMAN",3824,"E9PF16","E9PF16_HUMAN",null,null,"ACSF2"]
["21.8608","19.6767","15.0678",1,"18.1403",1,{"$nulls":3},"actin cytoskeleton organization;antigen processing and presentation of exogenous peptide antigen via MHC class II;barbed-end actin filament capping;blood coagulation;cytoskeleton organization;ER to Golgi vesicle-mediated transport;movement of cell or subcellular component;negative regulation of filopodium assembly;regulation of cell morphogenesis;regulation of lamellipodium assembly","actin binding;actin filament binding;cadherin binding","actin cytoskeleton;actin filament;cytoskeleton;cytosol;extracellular exosome;F-actin capping protein complex;sarcomere;WASH complex","Endocytosis",null,null,17,1,1,"64.3","4.7","4.7","31.35",0,"30.818",113370000,4,"0.938939",1,"12.155","2.00773","sp|P47756|CAPZB_HUMAN;tr|B1AK85|B1AK85_HUMAN","sp|P47756|CAPZB_HUMAN;tr|B1AK85|B1AK85_HUMAN",1613,"P47756","CAPZB_HUMAN","F-actin-capping protein subunit beta",null,"CAPZB"]
["19.9107","19.066","18.9664","19.8245",1,1,{"$nulls":9},1,1,1,"13.6","13.6","13.6","7.0879","0.0096416","2.2105",21968000,2,"0.893528",1,"12.0395","1.91652","tr|A0A0J9YXH7|A0A0J9YXH7_HUMAN;sp|Q99795|GPA33_HUMAN","tr|A0A0J9YXH7|A0A0J9YXH7_HUMAN;sp|Q99795|GPA33_HUMAN",4107,"A0A0J9YXH7","A0A0J9YXH7_HUMAN",null,null,"GPA33"]
["19.6422","19.1724","19.598","20.6176",1,1,{"$nulls":9},4,4,4,"38.7","38.7","38.7","14.844",0,"23.24",73213000,10,"0.847131",1,"11.9316","1.82415","tr|C9J6N5|C9J6N5_HUMAN;tr|C9JQ40|C9JQ40_HUMAN;tr|C9JW51|C9JW51_HUMAN;sp|Q9H098|F107B_HUMAN;tr|C9J3Q3|C9J3Q3_HUMAN;tr|X6RET8|X6RET8_HUMAN;tr|C9JP05|C9JP05_HUMAN;tr|F8WCJ2|F8WCJ2_HUMAN;tr|C9JYP1|C9JYP1_HUMAN;tr|C9J6Y8|C9J6Y8_HUMAN","tr|C9J6N5|C9J6N5_HUMAN;tr|C9JQ40|C9JQ40_HUMAN;tr|C9JW51|C9JW51_HUMAN;sp|Q9H098|F107B_HUMAN;tr|C9J3Q3|C9J3Q3_HUMAN;tr|X6RET8|X6RET8_HUMAN;tr|C9JP05|C9JP05_HUMAN",4381,"C9J6N5","C9J6N5_HUMAN",null,null,"FAM107B"]
["21.2946","16.2804","19.8632","20.9818",1,1,{"$nulls":3},"cell redox homeostasis",null,"cell",{"$nulls":3},1,1,1,"23.4","23.4","23.4","7.0271",0,"8.1894",18335000,2,"0.775424",1,"11.4854","1.68273","tr|M0QXH0|M0QXH0_HUMAN;sp|Q99757|THIOM_HUMAN","tr|M0QXH0|M0QXH0_HUMAN;sp|Q99757|THIOM_HUMAN",4106,"M0QXH0","M0QXH0_HUMAN",null,null,"TXN2"]
["18.7906","17.0233","16.4243",1,"16.3595",1,{"$nulls":3},"NADP metabolic process;regulation of apoptotic process","NADPH binding;NADPH:quinone reductase activity;protein homodimerization activity;quinone binding","cytosol;extracellular exosome","p53 signaling pathway",null,null,3,3,3,"12.3","12.3","12.3","35.536",0,"6.3224",18323000,2,"1.02577",1,"11.2929","2.18479","sp|Q53FA7|QORX_HUMAN;tr|H7BZH6|H7BZH6_HUMAN","sp|Q53FA7|QORX_HUMAN",2774,"Q53FA7","QORX_HUMAN","Quinone oxidoreductase PIG3",null,"TP53I3"]
["17.8701","15.0836","17.4189",1,"15.0723",1,{"$nulls":3},"DNA damage checkpoint;regulation of apoptotic process",null,"cytosol;nucleus",{"$nulls":3},1,1,1,"21.3","21.3","21.3","12.53","0.00041297","4.1455",5404600,1,"1.09424",1,"11.1001","2.32726","tr|B1AKZ5|B1AKZ5_HUMAN;sp|Q15121|PEA15_HUMAN","tr|B1AKZ5|B1AKZ5_HUMAN;sp|Q15121|PEA15_HUMAN",2562,"B1AKZ5","B1AKZ5_HUMAN",null,null,"PEA15"]
["17.7305","15.77","17.3275",1,"15.7095",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"20.8","20.8","20.8","14.164","0.0057185","2.3899",13253000,3,"1.05003",1,"11.0395","2.23496","tr|K7EQB1|K7EQB1_HUMAN;sp|Q9UNK0|STX8_HUMAN","tr|K7EQB1|K7EQB1_HUMAN;sp|Q9UNK0|STX8_HUMAN",5154,"K7EQB1","K7EQB1_HUMAN",null,null,"STX8"]
["16.065","16.8248","17.5306",1,"15.374",1,{"$nulls":5},"cytoplasm;cytosol;extracellular exosome;plasma membrane",{"$nulls":3},3,3,3,9,9,9,"63.964","0.00042726","4.8608",26227000,2,"1.07652",1,"11.0155","2.29013","sp|Q9BW04|SARG_HUMAN","sp|Q9BW04|SARG_HUMAN",4266,"Q9BW04","SARG_HUMAN","Specifically androgen-regulated gene protein",null,"SARG"]
["18.0909","17.1052","17.2011","17.5049",1,1,{"$nulls":9},2,2,2,"11.1","11.1","11.1","28.306","0.00042918","4.988",31665000,4,"0.929975",1,"10.9641","1.98966","tr|E9PJF5|E9PJF5_HUMAN;sp|Q9HCU9|BRMS1_HUMAN;tr|H0YCF7|H0YCF7_HUMAN;tr|G5E9I4|G5E9I4_HUMAN;tr|E9PPD1|E9PPD1_HUMAN","tr|E9PJF5|E9PJF5_HUMAN;sp|Q9HCU9|BRMS1_HUMAN;tr|H0YCF7|H0YCF7_HUMAN;tr|G5E9I4|G5E9I4_HUMAN;tr|E9PPD1|E9PPD1_HUMAN",4604,"E9PJF5","E9PJF5_HUMAN",null,null,"BRMS1"]
["17.0237","16.6824","16.9108",1,"16.0349",1,{"$nulls":3},"electron transport chain;fatty acid beta-oxidation using acyl-CoA dehydrogenase;respiratory electron transport chain;response to oxidative stress","4 iron, 4 sulfur cluster binding;electron transfer activity;electron-transferring-flavoprotein dehydrogenase activity;flavin adenine dinucleotide binding;metal ion binding;oxidoreductase activity;oxidoreductase activity, oxidizing metal ions with flavin as acceptor;quinone binding;ubiquinone binding","integral component of mitochondrial inner membrane;mitochondrial electron transfer flavoprotein complex;mitochondrial matrix;mitochondrial membrane",{"$nulls":3},4,4,4,"7.3","7.3","7.3","68.495","0.00042753","4.8759",33239000,1,"1.01696",1,"10.8606","2.16665","sp|Q16134|ETFD_HUMAN;tr|D6RAD5|D6RAD5_HUMAN","sp|Q16134|ETFD_HUMAN",2656,"Q16134","ETFD_HUMAN","Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial","TF-QO;TF-ubiquinone oxidoreductase","ETFDH"]
["16.8507","17.4805","15.9386",1,"15.9847",1,{"$nulls":3},"regulation of transcription, DNA-templated","metal ion binding","nucleoplasm;RSF complex",{"$nulls":3},3,3,3,6,6,6,"90.738",0,"8.6143",21888000,9,"1.00688",1,"10.7617","2.14594","tr|H0YCN2|H0YCN2_HUMAN;sp|Q96T23|RSF1_HUMAN;tr|H0YER1|H0YER1_HUMAN","tr|H0YCN2|H0YCN2_HUMAN;sp|Q96T23|RSF1_HUMAN;tr|H0YER1|H0YER1_HUMAN",4049,"H0YCN2","H0YCN2_HUMAN",null,null,"RSF1"]
["17.7711","16.46","16.2428",1,"16.211",1,{"$nulls":3},"mRNA processing;pseudouridine synthesis","pseudouridine synthase activity;RNA binding","cytosol;mitochondrial matrix",{"$nulls":3},3,3,3,10,10,10,"36.694","0.00021487","5.0186",51697000,1,"0.990144",1,"10.7543","2.11169","sp|O95900|TRUB2_HUMAN","sp|O95900|TRUB2_HUMAN",805,"O95900","TRUB2_HUMAN","Mitochondrial mRNA pseudouridine synthase TRUB2",null,"TRUB2"]
["16.3556","17.3855","16.3097",1,"15.9419",1,{"$nulls":3},"aging;behavioral response to cocaine;cerebellum development;copulation;exploration behavior;gamma-aminobutyric acid biosynthetic process;gamma-aminobutyric acid catabolic process;locomotory behavior;negative regulation of blood pressure;negative regulation of dopamine secretion;negative regulation of gamma-aminobutyric acid secretion;negative regulation of platelet aggregation;neurotransmitter catabolic process;positive regulation of aspartate secretion;positive regulation of dopamine metabolic process;positive regulation of heat generation;positive regulation of inhibitory postsynaptic potential;positive regulation of insulin secretion;positive regulation of prolactin secretion;positive regulation of uterine smooth muscle contraction;response to drug;response to ethanol;response to hypoxia;response to iron ion;response to nicotine","(S)-3-amino-2-methylpropionate transaminase activity;4-aminobutyrate transaminase activity;4-aminobutyrate:2-oxoglutarate transaminase activity;iron-sulfur cluster binding;metal ion binding;protein homodimerization activity;pyridoxal phosphate binding;succinate-semialdehyde dehydrogenase binding","4-aminobutyrate transaminase complex;extracellular exosome;mitochondrial matrix;mitochondrion;neuron projection","Alanine, aspartate and glutamate metabolism;beta-Alanine metabolism;Butanoate metabolism;GABAergic synapse;Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,2,2,2,5,5,5,"56.438",0,"6.2818",22264000,4,"1.00573",1,"10.703","2.1436","sp|P80404|GABT_HUMAN;tr|H3BRN4|H3BRN4_HUMAN;tr|H3BNQ7|H3BNQ7_HUMAN","sp|P80404|GABT_HUMAN;tr|H3BRN4|H3BRN4_HUMAN;tr|H3BNQ7|H3BNQ7_HUMAN",2072,"P80404","GABT_HUMAN","4-aminobutyrate aminotransferase, mitochondrial",null,"ABAT"]
["17.0002","13.3873","16.2596",1,"12.6178",1,{"$nulls":3},"cellular protein modification process;mannose metabolic process;neutrophil degranulation;oligosaccharide catabolic process;protein deglycosylation","alpha-mannosidase activity;carbohydrate binding;metal ion binding","azurophil granule lumen;extracellular exosome;extracellular region;extracellular space;lysosomal lumen","Lysosome;Other glycan degradation",null,null,4,4,4,7,7,7,"113.74",0,"11.491",16628000,3,"1.24503",1,"10.6764","2.65169","sp|O00754|MA2B1_HUMAN;tr|M0QZG6|M0QZG6_HUMAN;tr|M0R2P5|M0R2P5_HUMAN;tr|M0QZ24|M0QZ24_HUMAN","sp|O00754|MA2B1_HUMAN",264,"O00754","MA2B1_HUMAN","Lysosomal alpha-mannosidase","aman","MAN2B1"]
["16.2877","16.5046","16.1169",1,"15.2115",1,{"$nulls":3},"cell adhesion","structural molecule activity","extracellular matrix",{"$nulls":3},1,1,1,"2.5","2.5","2.5","70.733","0.0017398","3.1132",16237000,4,"1.04754",1,"10.5659","2.2298","tr|H7BXV5|H7BXV5_HUMAN;sp|P39060|COIA1_HUMAN","tr|H7BXV5|H7BXV5_HUMAN;sp|P39060|COIA1_HUMAN",1509,"H7BXV5","H7BXV5_HUMAN",null,null,"COL18A1"]
["17.8671","16.0351","16.5309","16.9037",1,1,{"$nulls":4},"phosphatase binding",{"$nulls":4},2,2,2,"6.4","6.4","6.4","68.041",0,"9.3714",33245000,8,"0.921222",1,"10.5098","1.97204","tr|A0A0G2JHC2|A0A0G2JHC2_HUMAN;sp|Q6NYC8|PPR18_HUMAN","tr|A0A0G2JHC2|A0A0G2JHC2_HUMAN;sp|Q6NYC8|PPR18_HUMAN",2990,"A0A0G2JHC2","A0A0G2JHC2_HUMAN",null,null,"PPP1R18"]
["16.6966","14.1156","17.1166",1,"14.4576",1,{"$nulls":3},"cellular response to hydrogen peroxide;cellular response to reactive nitrogen species;interleukin-4-mediated signaling pathway;mammary gland epithelial cell proliferation;mammary gland morphogenesis;negative regulation of transcription from RNA polymerase II promoter;negative regulation of type 2 immune response;positive regulation of isotype switching to IgE isotypes;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;regulation of cell proliferation;regulation of transcription from RNA polymerase II promoter;signal transduction;T-helper 1 cell lineage commitment","DNA binding transcription factor activity;identical protein binding;protein phosphatase binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;signal transducer activity;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytosol;membrane raft;nuclear chromatin;nuclear membrane;nucleoplasm","Hepatitis B;Inflammatory bowel disease (IBD);Jak-STAT signaling pathway;Necroptosis;Pathways in cancer;Th1 and Th2 cell differentiation;Th17 cell differentiation",null,null,3,3,3,"4.5","4.5","4.5","94.134",0,"5.6335",19540000,5,"1.07599",1,"10.4904","2.28901","sp|P42226|STAT6_HUMAN;tr|Q5FBW6|Q5FBW6_HUMAN;tr|G3V2L2|G3V2L2_HUMAN;tr|G3V2M3|G3V2M3_HUMAN;tr|G3V3E9|G3V3E9_HUMAN;tr|G3V2H4|G3V2H4_HUMAN;tr|G3V5I8|G3V5I8_HUMAN;tr|G3V568|G3V568_HUMAN;tr|G3V2X7|G3V2X7_HUMAN;tr|G3V370|G3V370_HUMAN;tr|H0YIY2|H0YIY2_HUMAN;tr|G3V5K5|G3V5K5_HUMAN;tr|H0YJH6|H0YJH6_HUMAN","sp|P42226|STAT6_HUMAN",1545,"P42226","STAT6_HUMAN","Signal transducer and activator of transcription 6",null,"STAT6"]
["17.6958","16.1478","16.5197","17.1799",1,1,{"$nulls":3},"ectodermal cell differentiation;embryonic ectodermal digestive tract development;endocytic recycling;Golgi to vacuole transport;lysosomal transport;protein transport;retrograde transport, endosome to Golgi","Rab GTPase binding;syntaxin binding","cytosol;EARP complex;endosome membrane;GARP complex;Golgi apparatus;membrane;perinuclear region of cytoplasm;recycling endosome;trans-Golgi network membrane",{"$nulls":3},3,3,3,"6.2","6.2","6.2","82.22",0,"10.733",30473000,4,"0.895329",1,"10.3945","1.92012","sp|Q8N1B4|VPS52_HUMAN","sp|Q8N1B4|VPS52_HUMAN",3374,"Q8N1B4","VPS52_HUMAN","Vacuolar protein sorting-associated protein 52 homolog",null,"VPS52"]
["16.7009","13.3151","16.2096",1,"13.2229",1,{"$nulls":3},"establishment of Sertoli cell barrier;histone H3-K9 trimethylation;histone H4-K20 trimethylation;positive regulation of transcription from RNA polymerase II promoter;regulation of gene expression by genetic imprinting;regulation of transcription from RNA polymerase II promoter;spermatogenesis;transcription, DNA-templated","histone deacetylase activity;transcription regulatory region DNA binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"3.4","3.4","3.4","147.81",0,"6.3278",26766000,9,"1.15462",1,"10.3342","2.45528","sp|Q4LE39|ARI4B_HUMAN;tr|X6RCR8|X6RCR8_HUMAN;tr|H0Y7Y8|H0Y7Y8_HUMAN;tr|H7C5R6|H7C5R6_HUMAN","sp|Q4LE39|ARI4B_HUMAN",2761,"Q4LE39","ARI4B_HUMAN","AT-rich interactive domain-containing protein 4B","RID domain-containing protein 4B","ARID4B"]
["17.7355","13.2294","16.0729",1,"14.1097",1,{"$nulls":3},"carbohydrate catabolic process;glycolipid catabolic process;glycoside catabolic process;glycosylceramide catabolic process;oligosaccharide metabolic process","alpha-galactosidase activity;alpha-N-acetylgalactosaminidase activity;protein homodimerization activity","cytoplasm;extracellular exosome;lysosome","Glycosphingolipid biosynthesis - globo and isoglobo series;Lysosome;Metabolic pathways",null,null,1,1,1,"4.9","4.9","4.9","46.564","0.0030263","2.7595",7698700,2,"1.06161",1,"10.3094","2.25903","sp|P17050|NAGAB_HUMAN","sp|P17050|NAGAB_HUMAN",1146,"P17050","NAGAB_HUMAN","Alpha-N-acetylgalactosaminidase",null,"NAGA"]
["16.2444","16.5124","16.7077",1,"16.8345",1,{"$nulls":3},"mRNA 3'-end processing;mRNA 3'-end processing by stem-loop binding and cleavage;mRNA cleavage;mRNA export from nucleus;mRNA polyadenylation;mRNA splicing, via spliceosome;termination of RNA polymerase II transcription","RNA binding","membrane;mRNA cleavage and polyadenylation specificity factor complex;nucleoplasm","mRNA surveillance pathway",null,null,7,7,7,"9.5","9.5","9.5","88.486",0,"7.0621",68064000,5,"0.902137",1,"10.21","1.93375","sp|Q9P2I0|CPSF2_HUMAN;tr|H0YJF4|H0YJF4_HUMAN","sp|Q9P2I0|CPSF2_HUMAN",4934,"Q9P2I0","CPSF2_HUMAN","Cleavage and polyadenylation specificity factor subunit 2",null,"CPSF2"]
["15.8141","15.1942","17.0716",1,1,"16.9465",{"$nulls":3},"biotin metabolic process;biotin transport;pantothenate metabolic process;pantothenate transmembrane transport;transmembrane transport;transport","sodium-dependent multivitamin transmembrane transporter activity","brush border membrane;integral component of plasma membrane;membrane;plasma membrane;vesicle membrane","Vitamin digestion and absorption",null,null,2,2,2,"3.8","3.8","3.8","68.641","0.00041399","4.181",10882000,3,"0.843608",1,"9.71115","1.81717","sp|Q9Y289|SC5A6_HUMAN","sp|Q9Y289|SC5A6_HUMAN",5212,"Q9Y289","SC5A6_HUMAN","Sodium-dependent multivitamin transporter","a(+)-dependent multivitamin transporter","SLC5A6"]
["17.5192","10.8516","14.4807",1,"11.7206",1,{"$nulls":4},"zinc ion binding",{"$nulls":4},3,3,3,"4.7","4.7","4.7","141.79",0,"29.747",27078000,3,"1.12474",1,"9.7103","2.39163","tr|A6NHN7|A6NHN7_HUMAN;sp|Q14202|ZMYM3_HUMAN;tr|A6NHB5|A6NHB5_HUMAN;tr|A6NC58|A6NC58_HUMAN;tr|A6NL54|A6NL54_HUMAN","tr|A6NHN7|A6NHN7_HUMAN;sp|Q14202|ZMYM3_HUMAN;tr|A6NHB5|A6NHB5_HUMAN;tr|A6NC58|A6NC58_HUMAN;tr|A6NL54|A6NL54_HUMAN",2455,"A6NHN7","A6NHN7_HUMAN",null,null,"ZMYM3"]
["14.4635","15.2003","16.6011",1,"15.397",1,{"$nulls":3},"mRNA export from nucleus;mRNA splicing, via spliceosome","RNA binding","nucleus;RES complex",{"$nulls":3},11,11,11,22,22,22,"70.52",0,"31.108",198330000,35,"0.929267",1,"9.62262","1.98823","sp|Q9BRD0|BUD13_HUMAN;tr|H7C462|H7C462_HUMAN","sp|Q9BRD0|BUD13_HUMAN",4158,"Q9BRD0","BUD13_HUMAN","BUD13 homolog",null,"BUD13"]
["15.7576","14.6039","15.2046",1,1,"14.8956",{"$nulls":3},"axon development;axon guidance;cell adhesion;cell migration;cell-matrix adhesion;chemotaxis;leukocyte migration;nervous system development;neuron projection development;positive regulation of axon extension;synapse organization","protein domain specific binding","axon;axonal growth cone;cell surface;dendrite;extracellular matrix;focal adhesion;integral component of membrane;neuronal cell body;plasma membrane","Axon guidance;Cell adhesion molecules (CAMs)",null,null,4,4,4,"4.3","4.3","4.3",140,0,"7.8912",35617000,5,"0.963757",1,"9.55683","2.05796","sp|P32004|L1CAM_HUMAN;tr|H0Y5C3|H0Y5C3_HUMAN","sp|P32004|L1CAM_HUMAN",1419,"P32004","L1CAM_HUMAN","Neural cell adhesion molecule L1","CAM-L1;-CAM-L1","L1CAM"]
["16.2107","16.4658","15.774","18.0862",1,1,{"$nulls":9},6,6,6,"11.9","11.9","11.9","94.659",0,"11.598",46044000,9,"0.763336",1,"9.45474","1.65902","sp|Q9Y2D5|AKAP2_HUMAN;tr|C9JVY5|C9JVY5_HUMAN","sp|Q9Y2D5|AKAP2_HUMAN;tr|C9JVY5|C9JVY5_HUMAN",5219,"Q9Y2D5","AKAP2_HUMAN","A-kinase anchor protein 2","KAP-2","AKAP2"]
["25.078","23.451","23.9232","23.1725",1,"19.9162",{"$nulls":3},"antibacterial humoral response;antimicrobial humoral immune response mediated by antimicrobial peptide;defense response to Gram-positive bacterium;innate immune response in mucosa;nucleosome assembly","DNA binding;protein heterodimerization activity","cytosol;extracellular exosome;extracellular space;nucleoplasm;nucleosome;nucleus","Alcoholism;Systemic lupus erythematosus;Viral carcinogenesis",null,null,7,1,1,"52.4","7.1","7.1","13.92","0.0021138","3.0199",2076200000,40,"0.612345",1,"9.4545","1.36444","sp|Q16778|H2B2E_HUMAN;sp|P33778|H2B1B_HUMAN;sp|P23527|H2B1O_HUMAN;sp|P06899|H2B1J_HUMAN;sp|Q8N257|H2B3B_HUMAN;sp|Q96A08|H2B1A_HUMAN;sp|Q6DRA6|H2B2D_HUMAN;sp|Q6DN03|H2B2C_HUMAN","sp|Q16778|H2B2E_HUMAN;sp|P33778|H2B1B_HUMAN;sp|P23527|H2B1O_HUMAN;sp|P06899|H2B1J_HUMAN;sp|Q8N257|H2B3B_HUMAN;sp|Q96A08|H2B1A_HUMAN",925,"Q16778","H2B2E_HUMAN","Histone H2B type 2-E",null,"HIST2H2BE"]
["15.9035","13.9578","17.4176",1,1,"17.5962",{"$nulls":9},3,3,3,"2.4","2.4","2.4","136.76","0.0019238","3.0372",43055000,3,"0.754316",1,"9.22757","1.64135","sp|Q6ZU35|K1211_HUMAN;tr|F5H1N7|F5H1N7_HUMAN","sp|Q6ZU35|K1211_HUMAN;tr|F5H1N7|F5H1N7_HUMAN",3088,"Q6ZU35","K1211_HUMAN","Uncharacterized protein KIAA1211",null,"KIAA1211"]
["15.8973","14.5689","15.5174",1,1,"16.4662",{"$nulls":5},"nucleus",{"$nulls":3},3,3,3,"3.3","3.3","3.3","160.74","0.0011974","3.5279",33899000,6,"0.821786",1,"9.17247","1.774","tr|F8VU51|F8VU51_HUMAN;tr|H0YIQ2|H0YIQ2_HUMAN;sp|P49750|YLPM1_HUMAN;tr|H0YI23|H0YI23_HUMAN","tr|F8VU51|F8VU51_HUMAN;tr|H0YIQ2|H0YIQ2_HUMAN;sp|P49750|YLPM1_HUMAN",5535,"F8VU51","F8VU51_HUMAN",null,null,"YLPM1"]
["15.1472","13.9665","15.1392","16.536",1,1,{"$nulls":3},"cornification;epidermis development;keratinocyte differentiation;peptide cross-linking","cadherin binding;intermediate filament binding;protein binding, bridging;structural molecule activity","cornified envelope;cytosol;desmosome;extracellular exosome;intermediate filament cytoskeleton",{"$nulls":3},6,6,6,"5.1","5.1","5.1","231.6",0,"22.004",43331000,11,"0.75903",1,"8.57229","1.65058","sp|Q92817|EVPL_HUMAN;tr|K7EKI0|K7EKI0_HUMAN","sp|Q92817|EVPL_HUMAN;tr|K7EKI0|K7EKI0_HUMAN",3719,"Q92817","EVPL_HUMAN","Envoplakin",null,"EVPL"]
["22.6211","23.1123",1,1,"19.2218",1,{"$nulls":3},"negative regulation of apoptotic process;oxidation-reduction process",null,"integral component of membrane;mitochondrial inner membrane;respiratory chain",{"$nulls":3},1,1,1,"27.4","27.4","27.4","11.528",0,"17.034",66770000,2,"0.37591",1,"8.50386","0.896183","sp|Q9BW72|HIG2A_HUMAN","sp|Q9BW72|HIG2A_HUMAN",4272,"Q9BW72","HIG2A_HUMAN","HIG1 domain family member 2A, mitochondrial",null,"HIGD2A"]
["14.1822","15.6791","12.4482",1,"15.1569",1,{"$nulls":3},"endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);negative regulation of cell proliferation;rRNA processing","RNA binding","90S preribosome;cytoplasm;nucleolus;nucleoplasm;plasma membrane;preribosome, small subunit precursor;small-subunit processome",{"$nulls":3},3,3,3,"1.2","1.2","1.2","318.38","0.00041649","4.306",34069000,2,"0.806035",1,"8.38421","1.74293","sp|O75691|UTP20_HUMAN","sp|O75691|UTP20_HUMAN",624,"O75691","UTP20_HUMAN","Small subunit processome component 20 homolog",null,"UTP20"]
["24.6383","23.8418","23.9842",1,"23.1045","23.5732",{"$nulls":3},"aging;ATP biosynthetic process;cristae formation;mitochondrial ATP synthesis coupled proton transport;response to hyperoxia","hydrogen ion transmembrane transporter activity;transmembrane transporter activity","extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial proton-transporting ATP synthase complex;proton-transporting ATP synthase complex, coupling factor F(o)","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,1,1,1,"4.4","4.4","4.4","24.817",0,"20.436",303210000,14,"0.481887",1,"8.26219","1.10879","sp|P00846|ATP6_HUMAN","sp|P00846|ATP6_HUMAN",836,"P00846","ATP6_HUMAN","ATP synthase subunit a",null,"MT-ATP6"]
["23.4176","23.0574","22.9701","21.1747",1,"22.8495",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"48.2","48.2","48.2","8.8131",0,"47.769",474480000,33,"0.507459",1,"8.14028","1.15925","tr|C9JAW5|C9JAW5_HUMAN;sp|Q9Y241|HIG1A_HUMAN;tr|C9JNU6|C9JNU6_HUMAN","tr|C9JAW5|C9JAW5_HUMAN;sp|Q9Y241|HIG1A_HUMAN;tr|C9JNU6|C9JNU6_HUMAN",5201,"C9JAW5","C9JAW5_HUMAN"]
["24.9615","24.4741","24.7098",1,"24.5573","24.5894",{"$nulls":9},1,1,1,"14.1","14.1","14.1","7.0662","0.001005","3.6316",492570000,8,"0.436169",1,"7.99954","1.01788","sp|Q9Y2S6|TMA7_HUMAN","sp|Q9Y2S6|TMA7_HUMAN",5239,"Q9Y2S6","TMA7_HUMAN","Translation machinery-associated protein 7",null,"TMA7"]
["19.7014","18.4774","20.1805",1,"15.3147","18.2052",{"$nulls":3},"protein import into mitochondrial inner membrane;protein targeting to mitochondrion","mitochondrion targeting sequence binding;protein channel activity","integral component of membrane;mitochondrial inner membrane;mitochondrial inner membrane protein insertion complex",{"$nulls":3},2,2,2,"25.8","25.8","25.8","20.031",0,"8.8175",18847000,3,"0.67536",1,"7.94646","1.48719","sp|Q9Y584|TIM22_HUMAN","sp|Q9Y584|TIM22_HUMAN",5346,"Q9Y584","TIM22_HUMAN","Mitochondrial import inner membrane translocase subunit Tim22",null,"TIMM22"]
["20.9066","19.7069",1,1,"15.9291",1,{"$nulls":3},"RNA processing",null,"exosome (RNase complex);nucleolus",{"$nulls":3},3,3,3,"7.6","7.6","7.6","46.977",0,"6.9731",84715000,6,"0.412108",1,"7.89481","0.969577","tr|D6RIY6|D6RIY6_HUMAN;sp|Q06265|EXOS9_HUMAN;tr|H0Y9L5|H0Y9L5_HUMAN;tr|D6R905|D6R905_HUMAN","tr|D6RIY6|D6RIY6_HUMAN;sp|Q06265|EXOS9_HUMAN",2204,"D6RIY6","D6RIY6_HUMAN"]
["20.9562","19.7245","20.6295",1,"18.8534","17.8864",{"$nulls":5},"cytosol;mitochondrion;nucleus",{"$nulls":3},5,5,5,"25.1","25.1","25.1","28.466",0,"18.883",97032000,8,"0.606303",1,"7.85682","1.35267","sp|Q9UFN0|NPS3A_HUMAN","sp|Q9UFN0|NPS3A_HUMAN",4996,"Q9UFN0","NPS3A_HUMAN","Protein NipSnap homolog 3A","ipSnap3A","NIPSNAP3A"]
["22.2669","17.5504","21.7007","21.2661","16.0246",1,{"$nulls":3},"blood coagulation;cellular protein metabolic process;chromatin organization;chromatin silencing at rDNA;interleukin-7-mediated signaling pathway;negative regulation of gene expression, epigenetic;nucleosome assembly;positive regulation of gene expression, epigenetic;regulation of gene silencing by miRNA;regulation of hematopoietic stem cell differentiation;regulation of megakaryocyte differentiation","histone binding;nucleosomal DNA binding;protein heterodimerization activity","extracellular exosome;extracellular region;nucleoplasm;nucleosome;nucleus","Alcoholism;Systemic lupus erythematosus;Transcriptional misregulation in cancer",null,null,5,1,1,"45.6","23.5","23.5","15.388",0,"58.72",44944000,3,"0.547719",1,"7.74246","1.23827","sp|Q71DI3|H32_HUMAN;sp|Q16695|H31T_HUMAN;sp|P68431|H31_HUMAN;tr|K7EMV3|K7EMV3_HUMAN;tr|B4DEB1|B4DEB1_HUMAN;sp|Q6NXT2|H3C_HUMAN;tr|K7ES00|K7ES00_HUMAN;tr|K7EP01|K7EP01_HUMAN","sp|Q71DI3|H32_HUMAN;sp|Q16695|H31T_HUMAN;sp|P68431|H31_HUMAN;tr|K7EMV3|K7EMV3_HUMAN;tr|B4DEB1|B4DEB1_HUMAN;sp|Q6NXT2|H3C_HUMAN;tr|K7ES00|K7ES00_HUMAN",3102,"Q71DI3","H32_HUMAN","Histone H3.2",null,"HIST2H3A;HIST2H3C;HIST2H3D"]
["22.3127","22.0117","21.1172",1,"20.6584","20.5849",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex I","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,4,4,4,"43.1","43.1","43.1","13.459",0,"13.028",103150000,9,"0.518263",1,"7.73277","1.1805","sp|Q16718|NDUA5_HUMAN;tr|F8WAS3|F8WAS3_HUMAN;tr|A0A087X1G1|A0A087X1G1_HUMAN;tr|H7BYD0|H7BYD0_HUMAN;tr|C9IZN5|C9IZN5_HUMAN;tr|A0A087WXR5|A0A087WXR5_HUMAN","sp|Q16718|NDUA5_HUMAN;tr|F8WAS3|F8WAS3_HUMAN;tr|A0A087X1G1|A0A087X1G1_HUMAN;tr|H7BYD0|H7BYD0_HUMAN;tr|C9IZN5|C9IZN5_HUMAN",2688,"Q16718","NDUA5_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5",null,"NDUFA5"]
["19.1756","16.8665","18.3101","15.1394","15.2234",1,{"$nulls":3},"angiogenesis;inositol phosphate metabolic process;intracellular signal transduction;labyrinthine layer blood vessel development;lipid catabolic process;regulation of cell proliferation","metal ion binding;phosphatidylinositol phospholipase C activity;signal transducer activity","cleavage furrow;cytosol;plasma membrane","AGE-RAGE signaling pathway in diabetic complications;Calcium signaling pathway;Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Thyroid hormone signaling pathway",null,null,18,18,18,"32.4","32.4","32.4","89.257",0,"122.62",576060000,71,"0.735679",1,"7.66317","1.60488","sp|Q8N3E9|PLCD3_HUMAN;tr|H0YGF8|H0YGF8_HUMAN;tr|F5GXC1|F5GXC1_HUMAN;tr|K7EQF2|K7EQF2_HUMAN","sp|Q8N3E9|PLCD3_HUMAN",3391,"Q8N3E9","PLCD3_HUMAN","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",null,"PLCD3"]
["20.092","20.7748","19.0518","19.0247","17.3311",1,{"$nulls":4},"growth factor activity",{"$nulls":4},2,2,2,"18.3","18.3","18.3","14.374",0,"23.55",211630000,22,"0.581235",1,"7.52096","1.30378","tr|E9PPJ5|E9PPJ5_HUMAN;sp|P21741|MK_HUMAN;tr|E9PLM6|E9PLM6_HUMAN","tr|E9PPJ5|E9PPJ5_HUMAN;sp|P21741|MK_HUMAN;tr|E9PLM6|E9PLM6_HUMAN",1231,"E9PPJ5","E9PPJ5_HUMAN",null,null,"MDK"]
["22.8414","22.7293",1,1,"22.0344",1,{"$nulls":3},"carbohydrate metabolic process;GPI anchor biosynthetic process;protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan;protein mannosylation;protein N-linked glycosylation via asparagine;protein O-linked mannosylation;regulation of protein stability",null,"dolichol-phosphate-mannose synthase complex;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;mannosyltransferase complex;membrane","Metabolic pathways;N-Glycan biosynthesis",null,null,1,1,1,"10.9","10.9","10.9","10.094","0.0013563","3.1545",58963000,4,"0.302682",1,"7.5121","0.744192","sp|Q9P2X0|DPM3_HUMAN","sp|Q9P2X0|DPM3_HUMAN",4944,"Q9P2X0","DPM3_HUMAN","Dolichol-phosphate mannosyltransferase subunit 3",null,"DPM3"]
["20.4979","18.6815","18.3473","19.5458","14.5054",1,{"$nulls":3},"carbohydrate metabolic process;N-acetylglucosamine catabolic process;N-acetylneuraminate catabolic process;UDP-N-acetylglucosamine biosynthetic process","metal ion binding;N-acetylglucosamine-6-phosphate deacetylase activity","cytosol;nucleus","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,4,4,4,"16.6","16.6","16.6","43.747","0.0037559","2.6687",70821000,3,"0.601563",1,"7.49184","1.34343","sp|Q9Y303|NAGA_HUMAN;tr|H3BTE3|H3BTE3_HUMAN;tr|H3BQ15|H3BQ15_HUMAN;tr|H3BSD5|H3BSD5_HUMAN;tr|H3BTZ6|H3BTZ6_HUMAN;tr|H3BSV9|H3BSV9_HUMAN","sp|Q9Y303|NAGA_HUMAN;tr|H3BTE3|H3BTE3_HUMAN",5260,"Q9Y303","NAGA_HUMAN","N-acetylglucosamine-6-phosphate deacetylase {ECO:0000305|PubMed:22692205}","lcNAc 6-P deacetylase {ECO:0000305}","AMDHD2"]
["22.8362","21.2678","21.3669",1,"21.1153","21.0932",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial ribosome",{"$nulls":3},3,3,3,"38.2","38.2","38.2","12.266",0,"5.7198",157800000,12,"0.479565",1,"7.42082","1.10419","sp|Q9BQC6|RT63_HUMAN","sp|Q9BQC6|RT63_HUMAN",4145,"Q9BQC6","RT63_HUMAN","Ribosomal protein 63, mitochondrial","MRP63","MRPL57"]
["24.0961","21.806","23.2246","23.0185",1,"23.0486",{"$nulls":3},"aerobic respiration;mitochondrial respiratory chain complex IV assembly",null,"integral component of membrane;mitochondrial membrane;mitochondrion","Thermogenesis",null,null,4,4,4,"33.9","33.9","33.9","13.291",0,"16.017",426750000,22,"0.425783",1,"7.35319","0.997071","sp|Q5RI15|COX20_HUMAN","sp|Q5RI15|COX20_HUMAN",2843,"Q5RI15","COX20_HUMAN","Cytochrome c oxidase protein 20 homolog",null,"COX20"]
["19.8229","18.1633","18.0906",1,"17.1561","15.9621",{"$nulls":3},"lipid storage;long-chain fatty acid transport;regulation of lipid metabolic process;response to drug;response to organic cyclic compound",null,"cytosol;endoplasmic reticulum;extracellular region;lipid droplet;nucleus;plasma membrane","PPAR signaling pathway",null,null,5,5,5,"15.6","15.6","15.6","48.075",0,"12.875",62710000,6,"0.630564",1,"7.31955","1.39993","sp|Q99541|PLIN2_HUMAN;tr|Q5SYF5|Q5SYF5_HUMAN;tr|Q5SYF3|Q5SYF3_HUMAN;tr|Q5SYF4|Q5SYF4_HUMAN","sp|Q99541|PLIN2_HUMAN",4074,"Q99541","PLIN2_HUMAN","Perilipin-2",null,"PLIN2"]
["22.9962",1,"20.9256",1,1,"21.0409",{"$nulls":9},1,1,1,22,22,22,"5.8668","0.00042105","4.555",48434000,3,"0.306888",1,"7.29363","0.753076","tr|F8VSA6|F8VSA6_HUMAN;tr|E9PS38|E9PS38_HUMAN;sp|Q15843|NEDD8_HUMAN;tr|S4R3E9|S4R3E9_HUMAN;tr|E9PL57|E9PL57_HUMAN","tr|F8VSA6|F8VSA6_HUMAN;tr|E9PS38|E9PS38_HUMAN;sp|Q15843|NEDD8_HUMAN;tr|S4R3E9|S4R3E9_HUMAN;tr|E9PL57|E9PL57_HUMAN",2651,"F8VSA6","F8VSA6_HUMAN",null,null,"NEDD8"]
["20.9024","20.6943",1,1,"18.8724",1,{"$nulls":9},1,1,1,"31.6","31.6","31.6","6.7215",0,"22.623",32769000,3,"0.336224",1,"7.24145","0.814481","tr|A0A087WU03|A0A087WU03_HUMAN","tr|A0A087WU03|A0A087WU03_HUMAN",5432,"A0A087WU03","A0A087WU03_HUMAN",null,null,"HNRNPDL"]
["22.5995","20.4087","21.8148",1,"20.3754","21.7882",{"$nulls":3},"autophagosome assembly;autophagy;cargo loading into COPII-coated vesicle;cell migration;COPII vesicle coating;defense response to bacterium;endocytosis;ER to Golgi vesicle-mediated transport;Golgi organization;growth hormone secretion;interleukin-8 secretion;melanosome transport;positive regulation of glycoprotein metabolic process;positive regulation of ubiquitin protein ligase activity;post-translational protein modification;retrograde vesicle-mediated transport, Golgi to ER;substrate adhesion-dependent cell spreading;vesicle transport along microtubule;vesicle-mediated transport;virion assembly","cadherin binding;GTP binding;GTPase activity","cytosol;early endosome;endoplasmic reticulum membrane;extracellular exosome;Golgi apparatus;Golgi membrane;melanosome;transport vesicle membrane","Legionellosis",null,null,12,5,5,"66.3","28.8","28.8","22.677",0,"87.804",440720000,36,"0.463168",1,"7.21982","1.07168","sp|P62820|RAB1A_HUMAN;tr|E7END7|E7END7_HUMAN","sp|P62820|RAB1A_HUMAN;tr|E7END7|E7END7_HUMAN",1992,"P62820","RAB1A_HUMAN","Ras-related protein Rab-1A",null,"RAB1A"]
["21.7021","21.6716",1,1,"20.8526",1,{"$nulls":3},"ER to Golgi vesicle-mediated transport;regulation of fibroblast apoptotic process",null,"COPII-coated ER to Golgi transport vesicle;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi apparatus;integral component of Golgi membrane;membrane",{"$nulls":3},2,2,2,"34.1","34.1","34.1","8.9687",0,"17.171",63179000,9,"0.305715",1,"7.17369","0.7506","sp|Q9Y5U9|IR3IP_HUMAN","sp|Q9Y5U9|IR3IP_HUMAN",5370,"Q9Y5U9","IR3IP_HUMAN","Immediate early response 3-interacting protein 1",null,"IER3IP1"]
["19.0733","18.9658","16.7407","16.8542","15.4114",1,{"$nulls":4},"RNA binding",{"$nulls":4},6,6,6,"17.4","17.4","17.4","44.638",0,"11.477",43410000,14,"0.631196",1,"7.17145","1.40117","tr|K7EQ03|K7EQ03_HUMAN;tr|K7EP90|K7EP90_HUMAN;sp|Q9BTD8|RBM42_HUMAN;tr|K7EML2|K7EML2_HUMAN;tr|K7ER08|K7ER08_HUMAN","tr|K7EQ03|K7EQ03_HUMAN;tr|K7EP90|K7EP90_HUMAN;sp|Q9BTD8|RBM42_HUMAN",4204,"K7EQ03","K7EQ03_HUMAN",null,null,"RBM42"]
["18.0892","16.1634","17.5185","13.9035","15.3868",1,{"$nulls":3},"cellular protein modification process;endocytosis;peptidyl-serine phosphorylation;regulation of cell shape;signal transduction;Wnt signaling pathway","ATP binding;protein kinase activity;protein serine/threonine kinase activity","cytoplasm;nucleus","Hedgehog signaling pathway",null,null,6,6,3,"14.1","14.1","9.4","51.388",0,"10.17",80488000,17,"0.710246",1,"7.16025","1.5552","sp|Q9Y6M4|KC1G3_HUMAN;tr|H0YBN6|H0YBN6_HUMAN;tr|K7ESB6|K7ESB6_HUMAN;tr|K7EP38|K7EP38_HUMAN;tr|A0A087WW97|A0A087WW97_HUMAN;tr|A0A087WZK4|A0A087WZK4_HUMAN;tr|A0A087WXD7|A0A087WXD7_HUMAN;tr|A0A087WWF5|A0A087WWF5_HUMAN","sp|Q9Y6M4|KC1G3_HUMAN;tr|H0YBN6|H0YBN6_HUMAN",5416,"Q9Y6M4","KC1G3_HUMAN","Casein kinase I isoform gamma-3","KI-gamma 3","CSNK1G3"]
["20.4915","18.7748","19.5088",1,"17.4477","18.8786",{"$nulls":3},"catabolic process;lipid catabolic process;low-density lipoprotein particle clearance;xenobiotic metabolic process","serine hydrolase activity;sterol esterase activity","endoplasmic reticulum membrane;integral component of membrane;membrane","Bile secretion;Cholesterol metabolism;Cortisol synthesis and secretion;Cushing syndrome",null,null,6,6,6,"22.1","22.1","22.1","45.807",0,"12.705",102300000,12,"0.549524",1,"7.14962","1.2418","sp|Q6PIU2|NCEH1_HUMAN;tr|A0A0A0MTJ9|A0A0A0MTJ9_HUMAN;tr|H7C046|H7C046_HUMAN","sp|Q6PIU2|NCEH1_HUMAN;tr|A0A0A0MTJ9|A0A0A0MTJ9_HUMAN;tr|H7C046|H7C046_HUMAN",3032,"Q6PIU2","NCEH1_HUMAN","Neutral cholesterol ester hydrolase 1","CEH","NCEH1"]
["21.0157","22.2049","21.5269",1,"21.2917","21.0398",{"$nulls":3},"protein transport",null,"integral component of membrane",{"$nulls":3},2,2,2,"13.5","13.5","13.5","25.728",0,"13.631",122050000,7,"0.457566",1,"7.13869","1.06055","sp|Q969E2|SCAM4_HUMAN;tr|K7EJJ4|K7EJJ4_HUMAN;tr|C9JWM2|C9JWM2_HUMAN","sp|Q969E2|SCAM4_HUMAN;tr|K7EJJ4|K7EJJ4_HUMAN;tr|C9JWM2|C9JWM2_HUMAN",3756,"Q969E2","SCAM4_HUMAN","Secretory carrier-associated membrane protein 4","ecretory carrier membrane protein 4","SCAMP4"]
["21.154","15.7181","17.8113",1,"15.5325","16.792",{"$nulls":3},"response to oxidative stress","glutathione peroxidase activity","cytosol",{"$nulls":3},4,4,4,"27.7","27.7","27.7","21.938",0,"10.158",56743000,7,"0.60039",1,"7.11964","1.34114","tr|A0A087WUQ6|A0A087WUQ6_HUMAN;sp|P07203|GPX1_HUMAN","tr|A0A087WUQ6|A0A087WUQ6_HUMAN;sp|P07203|GPX1_HUMAN",929,"A0A087WUQ6","A0A087WUQ6_HUMAN","Glutathione peroxidase {ECO:0000256|RuleBase:RU000499}",null,"GPX1"]
["20.5534","20.103",1,1,"18.333",1,{"$nulls":3},"caveola assembly",null,"caveola;Golgi membrane;integral component of membrane",{"$nulls":3},1,1,1,"15.9","15.9","15.9","12.953","0.0087687","2.248",27993000,3,"0.339484",1,"7.10781","0.821248","tr|E9PCT3|E9PCT3_HUMAN;sp|P51636|CAV2_HUMAN","tr|E9PCT3|E9PCT3_HUMAN;sp|P51636|CAV2_HUMAN",1746,"E9PCT3","E9PCT3_HUMAN","Caveolin {ECO:0000256|RuleBase:RU000680}",null,"CAV2"]
["21.4477","21.0419","20.1648",1,"20.7774","19.6734",{"$nulls":3},"cell adhesion;extracellular matrix organization;integrin-mediated signaling pathway;leukocyte migration;neutrophil degranulation;opsonization;positive regulation of cell proliferation;positive regulation of cell-cell adhesion;positive regulation of inflammatory response;positive regulation of phagocytosis;positive regulation of T cell activation;response to bacterium","thrombospondin receptor activity","extracellular exosome;integral component of plasma membrane;plasma membrane;specific granule membrane;tertiary granule membrane","ECM-receptor interaction",null,null,4,4,4,"11.8","11.8","11.8","35.213",0,"9.599",205770000,8,"0.477258",1,"7.0679","1.09963","sp|Q08722|CD47_HUMAN;tr|H7BYS8|H7BYS8_HUMAN","sp|Q08722|CD47_HUMAN",2236,"Q08722","CD47_HUMAN","Leukocyte surface antigen CD47",null,"CD47"]
["21.7134",1,"21.1103",1,1,"20.6622",{"$nulls":5},"endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},1,1,1,19,19,19,"18.038",0,"24.89",36809000,3,"0.303788",1,"7.05383","0.746531","tr|I3L1T3|I3L1T3_HUMAN;sp|Q9GZP9|DERL2_HUMAN","tr|I3L1T3|I3L1T3_HUMAN;sp|Q9GZP9|DERL2_HUMAN",4363,"I3L1T3","I3L1T3_HUMAN","Derlin {ECO:0000256|RuleBase:RU363059}",null,"DERL2"]
["19.7878","18.9245","19.1175",1,"17.7728","17.9062",{"$nulls":5},"Golgi apparatus;integral component of membrane",{"$nulls":3},6,6,6,"17.8","17.8","17.8","48.864",0,"12.593",83276000,6,"0.556081",1,"7.05028","1.25463","sp|Q6P4E1|CASC4_HUMAN;tr|H0YMR0|H0YMR0_HUMAN;tr|H0YM51|H0YM51_HUMAN","sp|Q6P4E1|CASC4_HUMAN;tr|H0YMR0|H0YMR0_HUMAN",3013,"Q6P4E1","CASC4_HUMAN","Protein CASC4",null,"CASC4"]
["21.6179","19.785","20.897","20.6066","19.5542",1,{"$nulls":9},1,1,1,"32.7","32.7","32.7","5.7044",0,"13.569",39733000,6,"0.478849",1,"7.04637","1.10278","tr|C9JL85|C9JL85_HUMAN;sp|P58546|MTPN_HUMAN","tr|C9JL85|C9JL85_HUMAN;sp|P58546|MTPN_HUMAN",1885,"C9JL85","C9JL85_HUMAN",null,null,"MTPN"]
["21.3357","18.9693","19.4192",1,"18.3991","19.2081",{"$nulls":3},"aging;ATP-dependent chromatin remodeling;brain development;embryonic organ development;heart development;histone acetylation;in utero embryonic development;methylation-dependent chromatin silencing;negative regulation of transcription from RNA polymerase II promoter;regulation of DNA methylation;regulation of signal transduction by p53 class mediator;response to estradiol;response to nutrient levels;tissue development;transcription, DNA-templated","chromatin binding;DNA binding;histone deacetylase activity;methyl-CpG binding","cytoplasm;heterochromatin;nuclear chromatin;nucleoplasm;NuRD complex;protein complex",{"$nulls":3},7,7,7,"23.4","23.4","23.4","32.844",0,"44.461",407320000,25,"0.516203",1,"7.03901","1.17645","sp|O95983|MBD3_HUMAN;tr|K7EIE8|K7EIE8_HUMAN;tr|A0A087WT34|A0A087WT34_HUMAN;tr|A0A087X1H1|A0A087X1H1_HUMAN;tr|A0A0A0MTS6|A0A0A0MTS6_HUMAN","sp|O95983|MBD3_HUMAN;tr|K7EIE8|K7EIE8_HUMAN",808,"O95983","MBD3_HUMAN","Methyl-CpG-binding domain protein 3",null,"MBD3"]
["20.5904","18.633","19.708",1,"17.2803","19.5436",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"17.7","17.7","17.7","16.805",0,"7.3908",27519000,4,"0.527694",1,"7.03584","1.19902","tr|H0Y870|H0Y870_HUMAN;tr|H0Y861|H0Y861_HUMAN;tr|Q8TDQ4|Q8TDQ4_HUMAN;tr|Q5SSC2|Q5SSC2_HUMAN;sp|Q9H0R3|TM222_HUMAN","tr|H0Y870|H0Y870_HUMAN;tr|H0Y861|H0Y861_HUMAN;tr|Q8TDQ4|Q8TDQ4_HUMAN;tr|Q5SSC2|Q5SSC2_HUMAN;sp|Q9H0R3|TM222_HUMAN",4395,"H0Y870","H0Y870_HUMAN",null,null,"TMEM222"]
["21.6309","18.9615",1,1,"18.5231",1,{"$nulls":5},"cytosol;nucleus;plasma membrane",{"$nulls":3},1,1,1,"14.2","14.2","14.2","10.897",0,"11.368",36103000,1,"0.331744",1,"7.0231","0.805164","sp|Q9GZP8|IMUP_HUMAN","sp|Q9GZP8|IMUP_HUMAN",4362,"Q9GZP8","IMUP_HUMAN","Immortalization up-regulated protein",null,"IMUP"]
["20.1777","20.0419","19.4574",1,"18.8406","18.8179",{"$nulls":9},2,2,2,"9.3","9.3","9.3","26.189","0.00021701","5.2606",58253000,5,"0.517027",1,"7.00619","1.17807","tr|F6UTR7|F6UTR7_HUMAN;sp|Q9NVA1|UQCC1_HUMAN;tr|B1AKV4|B1AKV4_HUMAN;tr|B1AKV6|B1AKV6_HUMAN;tr|B1AKV3|B1AKV3_HUMAN","tr|F6UTR7|F6UTR7_HUMAN;sp|Q9NVA1|UQCC1_HUMAN;tr|B1AKV4|B1AKV4_HUMAN;tr|B1AKV6|B1AKV6_HUMAN;tr|B1AKV3|B1AKV3_HUMAN",4753,"F6UTR7","F6UTR7_HUMAN",null,null,"UQCC1"]
["20.7349","19.5325",1,1,"18.2643",1,{"$nulls":5},"BRCA1-A complex;BRISC complex;cytosol",{"$nulls":3},3,3,3,"14.8","14.8","14.8","31.972",0,"13.576",66609000,3,"0.336147",1,"7.00104","0.814321","tr|F8W733|F8W733_HUMAN;sp|Q9NXR7|BRE_HUMAN;tr|C9J2G0|C9J2G0_HUMAN;tr|A0A075B7D2|A0A075B7D2_HUMAN","tr|F8W733|F8W733_HUMAN;sp|Q9NXR7|BRE_HUMAN;tr|C9J2G0|C9J2G0_HUMAN",4832,"F8W733","F8W733_HUMAN",null,null,"BABAM2"]
["21.4151","20.2949","20.388","20.0334",1,"20.0816",{"$nulls":3},"glutathione biosynthetic process;glutathione derivative biosynthetic process;leukotriene biosynthetic process;lipid metabolic process;membrane lipid catabolic process;positive regulation of inflammatory response;response to lipopolysaccharide;response to organonitrogen compound;xenobiotic metabolic process","enzyme activator activity;glutathione peroxidase activity;glutathione transferase activity;leukotriene-C4 synthase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;intracellular membrane-bounded organelle;membrane;nuclear envelope;organelle membrane;plasma membrane","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Fluid shear stress and atherosclerosis;Glutathione metabolism;Hepatocellular carcinoma;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pathways in cancer;Platinum drug resistance",null,null,1,1,1,"9.5","9.5","9.5","16.62","0.0019246","3.0388",68254000,15,"0.477084",1,"6.99433","1.09928","sp|Q99735|MGST2_HUMAN","sp|Q99735|MGST2_HUMAN",4103,"Q99735","MGST2_HUMAN","Microsomal glutathione S-transferase 2","icrosomal GST-2","MGST2"]
["19.414","21.142","19.1695","18.5206",1,"19.2772",{"$nulls":9},1,1,1,"16.2","16.2","16.2","9.116","0.0011744","3.2632",27741000,5,"0.50894",1,"6.97587","1.16216","tr|K7ELP6|K7ELP6_HUMAN;sp|Q53F19|NCBP3_HUMAN","tr|K7ELP6|K7ELP6_HUMAN;sp|Q53F19|NCBP3_HUMAN",2773,"K7ELP6","K7ELP6_HUMAN",null,null,"NCBP3"]
["21.4357","19.4182","20.24","19.6479","19.5437",1,{"$nulls":3},"mRNA processing;regulation of alternative mRNA splicing, via spliceosome;RNA splicing","RNA binding","nuclear speck;nucleoplasm;spliceosomal complex",{"$nulls":3},5,5,5,"16.5","16.5","16.5","59.38",0,"29.304",125050000,21,"0.48707",1,"6.96744","1.11903","sp|Q8WXA9|SREK1_HUMAN","sp|Q8WXA9|SREK1_HUMAN",3642,"Q8WXA9","SREK1_HUMAN","Splicing regulatory glutamine/lysine-rich protein 1",null,"SREK1"]
[1,"20.0603","21.1037","19.3662",1,1,{"$nulls":5},"endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},1,1,1,"4.1","4.1","4.1","21.862","0.0057259","2.3978",59990000,3,"0.316944",1,"6.93257","0.774232","tr|A8MT72|A8MT72_HUMAN;tr|Q2NKQ5|Q2NKQ5_HUMAN;sp|Q16799|RTN1_HUMAN","tr|A8MT72|A8MT72_HUMAN;tr|Q2NKQ5|Q2NKQ5_HUMAN;sp|Q16799|RTN1_HUMAN",2697,"A8MT72","A8MT72_HUMAN","Reticulon {ECO:0000256|RuleBase:RU210713}",null,"RTN1"]
["19.1963",1,"17.297",1,"14.7036",1,{"$nulls":3},"apoptotic process;central nervous system development;mRNA 3'-end processing;mRNA export from nucleus;negative regulation of apoptotic process;RNA export from nucleus;RNA splicing;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus","RNA binding","nuclear body;nuclear speck;nucleoplasm;nucleus;THO complex;THO complex part of transcription export complex;transcription export complex","RNA transport",null,null,6,6,6,"23.2","23.2","23.2","37.535",0,"23.547",137080000,16,"0.398036",1,"6.92987","0.941158","sp|Q86W42|THOC6_HUMAN","sp|Q86W42|THOC6_HUMAN",3237,"Q86W42","THOC6_HUMAN","THO complex subunit 6 homolog",null,"THOC6"]
["21.8891",1,"21.4188",1,1,"21.6317",{"$nulls":9},4,4,4,"33.9","33.9","33.9","19.291",0,"17.363",162120000,5,"0.285739",1,"6.89209","0.708183","sp|Q9GZN8|CT027_HUMAN;tr|H7BYU9|H7BYU9_HUMAN","sp|Q9GZN8|CT027_HUMAN;tr|H7BYU9|H7BYU9_HUMAN",4360,"Q9GZN8","CT027_HUMAN","UPF0687 protein C20orf27",null,"C20orf27"]
["20.0198","18.8111","20.1977",1,"19.0134","18.4196",{"$nulls":3},"regulation of cell proliferation","hydrolase activity","cytoplasm;extracellular exosome;nucleoplasm",{"$nulls":3},2,2,2,"13.4","13.4","13.4",21,0,"28.89",52532000,4,"0.507273",1,"6.86523","1.15888","sp|O75884|RBBP9_HUMAN;tr|A0A087WYQ5|A0A087WYQ5_HUMAN","sp|O75884|RBBP9_HUMAN;tr|A0A087WYQ5|A0A087WYQ5_HUMAN",645,"O75884","RBBP9_HUMAN","Putative hydrolase RBBP9",null,"RBBP9"]
["22.1079","21.2966","20.1888","21.3071","20.7481",1,{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit",{"$nulls":3},2,2,2,"41.5","41.5","41.5","13.664",0,"28.6",62250000,9,"0.438056",1,"6.84602","1.02165","sp|Q86TS9|RM52_HUMAN;tr|G3V3U6|G3V3U6_HUMAN;tr|G5E9P5|G5E9P5_HUMAN","sp|Q86TS9|RM52_HUMAN;tr|G3V3U6|G3V3U6_HUMAN;tr|G5E9P5|G5E9P5_HUMAN",3209,"Q86TS9","RM52_HUMAN","39S ribosomal protein L52, mitochondrial","52mt;RP-L52","MRPL52"]
["22.3288","20.7725","21.5991","22.002",1,"21.1628",{"$nulls":3},"cellular response to gamma radiation;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;negative regulation of cell death;regulation of ion transmembrane transport","voltage-gated ion channel activity","extracellular exosome;integral component of membrane;nuclear outer membrane;sarcoplasmic reticulum membrane",{"$nulls":3},1,1,1,"4.9","4.9","4.9","26.21",0,"14.048",231320000,7,"0.424738",1,"6.8452","0.994974","sp|Q9BVC6|TM109_HUMAN","sp|Q9BVC6|TM109_HUMAN",4248,"Q9BVC6","TM109_HUMAN","Transmembrane protein 109",null,"TMEM109"]
["21.3446","20.9552","20.9332",1,"21.0986","20.6137",{"$nulls":5},"nuclear body;nuclear membrane;nucleolus;nucleus",{"$nulls":3},2,2,2,"46.6","46.6","46.6","6.6846","0.000424","4.6853",47426000,3,"0.443755",1,"6.84027","1.03303","tr|B8ZZJ0|B8ZZJ0_HUMAN;tr|B9A032|B9A032_HUMAN;sp|P63165|SUMO1_HUMAN;tr|B8ZZN6|B8ZZN6_HUMAN","tr|B8ZZJ0|B8ZZJ0_HUMAN;tr|B9A032|B9A032_HUMAN;sp|P63165|SUMO1_HUMAN;tr|B8ZZN6|B8ZZN6_HUMAN",2024,"B8ZZJ0","B8ZZJ0_HUMAN",null,null,"SUMO1"]
["20.2043","16.2398","17.7197",1,"15.6456","17.017",{"$nulls":3},"cellular amino acid metabolic process;response to toxic substance;xenobiotic metabolic process","alpha-amino-acid esterase activity;hydrolase activity","extracellular exosome;mitochondrial outer membrane;mitochondrion",{"$nulls":3},2,2,2,"9.6","9.6","9.6","32.542",0,"14.002",35802000,4,"0.579562",1,"6.83371","1.30051","sp|Q86WA6|BPHL_HUMAN;tr|Q49AI2|Q49AI2_HUMAN;tr|B4DML3|B4DML3_HUMAN","sp|Q86WA6|BPHL_HUMAN;tr|Q49AI2|Q49AI2_HUMAN;tr|B4DML3|B4DML3_HUMAN",3241,"Q86WA6","BPHL_HUMAN","Valacyclovir hydrolase","ACVase;alacyclovirase","BPHL"]
["19.4716","18.1091","18.7893",1,"16.9104","18.0073",{"$nulls":3},"animal organ regeneration;hyperosmotic salinity response;mitochondrial electron transport, ubiquinol to cytochrome c;proton transport;response to cadmium ion;response to calcium ion;response to cobalamin;response to copper ion;response to drug;response to ethanol;response to glucagon;response to heat;response to hyperoxia;response to hypoxia;response to mercury ion;response to toxic substance","metal ion binding;protein complex binding;ubiquinol-cytochrome-c reductase activity","integral component of mitochondrial inner membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrion","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,1,1,1,"2.4","2.4","2.4","42.717","0.0071639","2.3202",11743000,3,"0.547276",1,"6.81743","1.2374","sp|P00156|CYB_HUMAN","sp|P00156|CYB_HUMAN",818,"P00156","CYB_HUMAN","Cytochrome b",null,"MT-CYB"]
["20.1368","23.0692","21.5704",1,"22.2236","21.1067",{"$nulls":9},2,2,2,25,25,25,"13.389",0,"6.5713",95660000,5,"0.417759",1,"6.81537","0.980952","tr|K7EM09|K7EM09_HUMAN;tr|K7EPR0|K7EPR0_HUMAN;tr|K7ELQ9|K7ELQ9_HUMAN;sp|Q6UW68|TM205_HUMAN","tr|K7EM09|K7EM09_HUMAN;tr|K7EPR0|K7EPR0_HUMAN;tr|K7ELQ9|K7ELQ9_HUMAN;sp|Q6UW68|TM205_HUMAN",3056,"K7EM09","K7EM09_HUMAN",null,null,"TMEM205"]
["21.094","22.687","22.6587",1,"22.3573","22.6984",{"$nulls":3},"chemotaxis;cytokine-mediated signaling pathway;ion transport","chemokine binding;ion transmembrane transporter activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;membrane;plasma membrane",{"$nulls":3},2,2,2,"18.4","18.4","18.4","16.691",0,"8.141",168090000,5,"0.399559",1,"6.79467","0.944242","sp|Q04941|PLP2_HUMAN","sp|Q04941|PLP2_HUMAN",2191,"Q04941","PLP2_HUMAN","Proteolipid protein 2",null,"PLP2"]
["19.6001","19.241","18.4176","18.3119",1,"17.5699",{"$nulls":3},"Golgi ribbon formation;protein transport",null,"cis-Golgi network;endoplasmic reticulum exit site;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus;integral component of membrane",{"$nulls":3},2,2,2,"9.6","9.6","9.6","26.005",0,"5.8525",31202000,2,"0.528016",1,"6.79228","1.19965","sp|Q9Y3A6|TMED5_HUMAN;tr|M0R072|M0R072_HUMAN;tr|B1AKT3|B1AKT3_HUMAN","sp|Q9Y3A6|TMED5_HUMAN;tr|M0R072|M0R072_HUMAN;tr|B1AKT3|B1AKT3_HUMAN",5280,"Q9Y3A6","TMED5_HUMAN","Transmembrane emp24 domain-containing protein 5",null,"TMED5"]
["22.0965","20.932","19.2375","21.4784","19.4706",1,{"$nulls":3},"vacuolar transport",null,"intracellular",{"$nulls":3},2,2,2,"18.6","18.6","18.6","12.939",0,"7.2238",74247000,7,"0.442641",1,"6.77237","1.03081","tr|I3L3E4|I3L3E4_HUMAN;sp|Q96FZ7|CHMP6_HUMAN;tr|I3L4G8|I3L4G8_HUMAN;tr|I3L4A1|I3L4A1_HUMAN","tr|I3L3E4|I3L3E4_HUMAN;sp|Q96FZ7|CHMP6_HUMAN;tr|I3L4G8|I3L4G8_HUMAN;tr|I3L4A1|I3L4A1_HUMAN",3883,"I3L3E4","I3L3E4_HUMAN",null,null,"CHMP6"]
["20.8139","18.7145","19.101",1,"18.7965","18.5729",{"$nulls":9},3,3,3,"19.4","19.4","19.4","26.928",0,"7.207",53249000,5,"0.497064",1,"6.75337","1.13876","sp|Q7Z309|F122B_HUMAN;tr|G1UD79|G1UD79_HUMAN","sp|Q7Z309|F122B_HUMAN;tr|G1UD79|G1UD79_HUMAN",3149,"Q7Z309","F122B_HUMAN","Protein FAM122B",null,"FAM122B"]
["19.1303","17.559","17.5304",1,"16.3599","16.6748",{"$nulls":9},1,1,1,"2.9","2.9","2.9","30.955","0.0087719","2.2523",27443000,2,"0.576157",1,"6.72833","1.29387","tr|A0A0M3HER4|A0A0M3HER4_HUMAN;sp|Q8TD08|MK15_HUMAN","tr|A0A0M3HER4|A0A0M3HER4_HUMAN;sp|Q8TD08|MK15_HUMAN",3556,"A0A0M3HER4"]
["21.6797",1,"18.9024",1,1,"19.3986",{"$nulls":3},"vesicle-mediated transport",null,"integral component of membrane",{"$nulls":3},2,2,2,"20.3","20.3","20.3","8.2139",0,"9.1154",23196000,4,"0.307355",1,"6.72783","0.754062","tr|G3V1U5|G3V1U5_HUMAN;tr|F5H6U7|F5H6U7_HUMAN;sp|Q9Y3E0|GOT1B_HUMAN","tr|G3V1U5|G3V1U5_HUMAN;tr|F5H6U7|F5H6U7_HUMAN;sp|Q9Y3E0|GOT1B_HUMAN",5295,"G3V1U5","G3V1U5_HUMAN"]
["18.5324","17.7275","18.9547","16.9516","17.0903",1,{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,"13.5","13.5","13.5","27.354","0.00041195","4.1139",31026000,2,"0.55691",1,"6.72422","1.25626","sp|Q9H3H3|CK068_HUMAN","sp|Q9H3H3|CK068_HUMAN",4444,"Q9H3H3","CK068_HUMAN","UPF0696 protein C11orf68",null,"C11orf68"]
["18.8867","16.66","17.2276",1,"15.7277","15.8901",{"$nulls":3},"acylglycerol acyl-chain remodeling;cellular protein metabolic process;lipid homeostasis;lipid particle organization;lipid storage;negative regulation of sequestering of triglyceride;positive regulation of triglyceride catabolic process;post-translational protein modification;triglyceride catabolic process","acylglycerol O-acyltransferase activity;lipoprotein lipase activity;triglyceride lipase activity","cytoplasm;cytosol;endoplasmic reticulum lumen;endoplasmic reticulum membrane;integral component of membrane;lipid droplet;membrane;nucleoplasm;plasma membrane","Glycerolipid metabolism;Metabolic pathways;Regulation of lipolysis in adipocytes;Thermogenesis",null,null,3,3,3,"11.1","11.1","11.1","55.315",0,"9.2739",21669000,5,"0.604291",1,"6.71881","1.34875","sp|Q96AD5|PLPL2_HUMAN","sp|Q96AD5|PLPL2_HUMAN",3788,"Q96AD5","PLPL2_HUMAN","Patatin-like phospholipase domain-containing protein 2",null,"PNPLA2"]
["19.274","20.7652","19.8416",1,"19.7429","19.0055",{"$nulls":3},"regulated exocytosis;synaptic vesicle membrane organization",null,"cell junction;extracellular exosome;integral component of membrane;lipid droplet;neuromuscular junction;synaptic vesicle membrane",{"$nulls":3},3,3,3,"12.5","12.5","12.5","24.81",0,"11.834",46212000,7,"0.473553",1,"6.71081","1.09229","sp|O43760|SNG2_HUMAN;tr|K7ELD9|K7ELD9_HUMAN;tr|K7ENG9|K7ENG9_HUMAN;tr|K7ELS8|K7ELS8_HUMAN","sp|O43760|SNG2_HUMAN;tr|K7ELD9|K7ELD9_HUMAN;tr|K7ENG9|K7ENG9_HUMAN;tr|K7ELS8|K7ELS8_HUMAN",451,"O43760","SNG2_HUMAN","Synaptogyrin-2 {ECO:0000305}",null,"SYNGR2"]
["20.1895","20.8077","19.3547","19.1127","20.1337",1,{"$nulls":3},"sphingomyelin catabolic process","sphingomyelin phosphodiesterase activity","extracellular space",{"$nulls":3},4,4,4,15,15,15,"45.314",0,"11.162",107990000,9,"0.4653",1,"6.70186","1.07592","tr|F8VWW8|F8VWW8_HUMAN;sp|Q92485|ASM3B_HUMAN;tr|Q5T0Y8|Q5T0Y8_HUMAN","tr|F8VWW8|F8VWW8_HUMAN;sp|Q92485|ASM3B_HUMAN;tr|Q5T0Y8|Q5T0Y8_HUMAN",3663,"F8VWW8","F8VWW8_HUMAN",null,null,"SMPDL3B"]
["21.8936",1,"20.5273","21.329",1,1,{"$nulls":3},"protein folding","chaperone binding;unfolded protein binding","cytoplasm;cytosol;mitochondrion;nucleus;prefoldin complex",{"$nulls":3},2,2,2,"20.1","20.1","20.1","15.314","0.00021561","5.0703",33832000,3,"0.282054",1,"6.69727","0.700301","sp|Q9NQP4|PFD4_HUMAN;tr|E9PQY2|E9PQY2_HUMAN","sp|Q9NQP4|PFD4_HUMAN;tr|E9PQY2|E9PQY2_HUMAN",4657,"Q9NQP4","PFD4_HUMAN","Prefoldin subunit 4",null,"PFDN4"]
["21.4963","19.4609","21.0521",1,"19.8662","21.067",{"$nulls":3},"carbohydrate metabolic process;generation of precursor metabolites and energy;glucosamine catabolic process;N-acetylglucosamine metabolic process;single fertilization","glucosamine-6-phosphate deaminase activity","cytoplasm;cytosol;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,10,10,6,"57.4","57.4","36.7","32.668",0,"64.587",370520000,33,"0.43984",1,"6.69201","1.02521","sp|P46926|GNPI1_HUMAN;tr|D6R9P4|D6R9P4_HUMAN;tr|D6RAY7|D6RAY7_HUMAN;tr|D6RFF8|D6RFF8_HUMAN;tr|D6RB13|D6RB13_HUMAN;tr|D6R917|D6R917_HUMAN;tr|V9GYK3|V9GYK3_HUMAN;tr|D6RFK5|D6RFK5_HUMAN;tr|V9GYW0|V9GYW0_HUMAN","sp|P46926|GNPI1_HUMAN;tr|D6R9P4|D6R9P4_HUMAN;tr|D6RAY7|D6RAY7_HUMAN;tr|D6RFF8|D6RFF8_HUMAN;tr|D6RB13|D6RB13_HUMAN;tr|D6R917|D6R917_HUMAN",1604,"P46926","GNPI1_HUMAN","Glucosamine-6-phosphate isomerase 1",null,"GNPDA1"]
["20.6153","19.0624","20.3827","20.7421","18.2475",1,{"$nulls":5},"actin cytoskeleton;cytosol",{"$nulls":3},10,3,3,31,"14.7","14.7","28.524",0,"13.283",152280000,7,"0.464647",1,"6.69023","1.07462","tr|F5H7S3|F5H7S3_HUMAN;tr|H7BYY1|H7BYY1_HUMAN;tr|H0YK48|H0YK48_HUMAN;tr|B7Z596|B7Z596_HUMAN;tr|H0YN06|H0YN06_HUMAN","tr|F5H7S3|F5H7S3_HUMAN;tr|H7BYY1|H7BYY1_HUMAN;tr|H0YK48|H0YK48_HUMAN;tr|B7Z596|B7Z596_HUMAN",5483,"F5H7S3","F5H7S3_HUMAN",null,null,"TPM1"]
["18.4908","18.607","19.1147",1,"16.2925","18.8688",{"$nulls":4},"metal ion binding",{"$nulls":4},6,3,3,"25.1","14.1","14.1","28.14",0,"16.002",56930000,9,"0.527073",1,"6.68372","1.1978","tr|O95205|O95205_HUMAN;sp|Q5VZF2|MBNL2_HUMAN;tr|C9J4T8|C9J4T8_HUMAN;tr|B1AKI6|B1AKI6_HUMAN;sp|Q9NUK0|MBNL3_HUMAN","tr|O95205|O95205_HUMAN;sp|Q5VZF2|MBNL2_HUMAN",2910,"O95205","O95205_HUMAN",null,null,"MBLL"]
["19.867","21.0253","21.0643",1,"20.8493","20.0621",{"$nulls":3},"cell division;cell separation after cytokinesis;ESCRT III complex disassembly;establishment of protein localization;mitotic metaphase plate congression;multivesicular body assembly;nucleus organization;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;vacuolar transport;viral budding via host ESCRT complex","identical protein binding;protein domain specific binding","cytosol;endosome membrane;ESCRT III complex;extracellular exosome;late endosome membrane;membrane coat;midbody;nucleus","Endocytosis;Necroptosis",null,null,2,2,2,"8.5","8.5","8.5","22.109",0,"5.3644",83053000,5,"0.441129",1,"6.68175","1.02779","sp|Q7LBR1|CHM1B_HUMAN","sp|Q7LBR1|CHM1B_HUMAN",3136,"Q7LBR1","CHM1B_HUMAN","Charged multivesicular body protein 1b",null,"CHMP1B"]
["20.9917","21.3031",1,1,"21.2643",1,{"$nulls":4},"ATP binding",{"$nulls":4},2,1,1,"26.6","10.1","10.1","12.421","0.0057291","2.4083",48475000,3,"0.28235",1,"6.67682","0.700935","tr|A0A087WW00|A0A087WW00_HUMAN;tr|C9J9H9|C9J9H9_HUMAN;sp|Q9Y2X8|UB2D4_HUMAN;sp|P51668|UB2D1_HUMAN","tr|A0A087WW00|A0A087WW00_HUMAN;tr|C9J9H9|C9J9H9_HUMAN;sp|Q9Y2X8|UB2D4_HUMAN;sp|P51668|UB2D1_HUMAN",1751,"A0A087WW00","A0A087WW00_HUMAN",null,null,"UBE2D1"]
["18.2229","17.069","20.1318","17.1754","17.223",1,{"$nulls":9},1,1,1,"5.9","5.9","5.9","31.371",0,"13.37",24912000,2,"0.538195",1,"6.67509","1.21962","tr|B4DMI0|B4DMI0_HUMAN;tr|E9PBM2|E9PBM2_HUMAN;sp|Q8WUF8|F172A_HUMAN","tr|B4DMI0|B4DMI0_HUMAN;tr|E9PBM2|E9PBM2_HUMAN;sp|Q8WUF8|F172A_HUMAN",3601,"B4DMI0","B4DMI0_HUMAN",null,null,"FAM172A"]
["20.5374","20.121",1,"19.7329",1,1,{"$nulls":3},"mRNA 5'-splice site recognition;mRNA splicing, via spliceosome;spliceosomal snRNP assembly","pre-mRNA 5'-splice site binding;protein homodimerization activity;RNA binding;single-stranded RNA binding;zinc ion binding","Cajal body;commitment complex;nucleoplasm;prespliceosome;U1 snRNP","Spliceosome",null,null,2,2,2,"18.9","18.9","18.9","17.394","0.00042079","4.5327",70196000,3,"0.300788",1,"6.64185","0.740185","sp|P09234|RU1C_HUMAN;tr|A0A0A0MRR7|A0A0A0MRR7_HUMAN","sp|P09234|RU1C_HUMAN;tr|A0A0A0MRR7|A0A0A0MRR7_HUMAN",985,"P09234","RU1C_HUMAN","U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}","1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153};1C {ECO:0000255|HAMAP-Rule:MF_03153};1-C {ECO:0000255|HAMAP-Rule:MF_03153}","SNRPC"]
["20.8318","18.3931","20.3986","20.6361","18.0845",1,{"$nulls":5},"cytoplasm",{"$nulls":3},1,1,1,"29.5","29.5","29.5","5.1538","0.0028458","2.8188",15322000,1,"0.46149",1,"6.63432","1.06835","tr|D6RAX1|D6RAX1_HUMAN;tr|D6RCT8|D6RCT8_HUMAN;tr|A6NFV8|A6NFV8_HUMAN;sp|Q96EV8|DTBP1_HUMAN","tr|D6RAX1|D6RAX1_HUMAN;tr|D6RCT8|D6RCT8_HUMAN;tr|A6NFV8|A6NFV8_HUMAN;sp|Q96EV8|DTBP1_HUMAN",3866,"D6RAX1","D6RAX1_HUMAN",null,null,"DTNBP1"]
["19.2249","17.853","18.4008",1,"16.5629","18.0323",{"$nulls":9},1,1,1,"19.5","19.5","19.5","9.5175",0,"7.7458",13742000,4,"0.53486",1,"6.62783","1.21308","tr|J3KRR0|J3KRR0_HUMAN;tr|J3QQM5|J3QQM5_HUMAN;sp|Q9BT23|LIMD2_HUMAN","tr|J3KRR0|J3KRR0_HUMAN;tr|J3QQM5|J3QQM5_HUMAN;sp|Q9BT23|LIMD2_HUMAN",4195,"J3KRR0","J3KRR0_HUMAN"]
["19.3254","15.8554",1,1,"14.3584",1,{"$nulls":3},"cell redox homeostasis;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;negative regulation of protein phosphorylation;positive regulation of ATPase activity;protein folding in endoplasmic reticulum;response to endoplasmic reticulum stress;ubiquitin-dependent ERAD pathway","ATPase activator activity;ATPase binding;chaperone binding;disulfide oxidoreductase activity;Hsp70 protein binding;misfolded protein binding;oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;protein disulfide oxidoreductase activity","endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;membrane","Protein processing in endoplasmic reticulum",null,null,3,3,3,"4.5","4.5","4.5","91.079","0.0010117","3.7319",30738000,2,"0.388342",1,"6.60743","0.921499","sp|Q8IXB1|DJC10_HUMAN;tr|E7EP04|E7EP04_HUMAN","sp|Q8IXB1|DJC10_HUMAN",3317,"Q8IXB1","DJC10_HUMAN","DnaJ homolog subfamily C member 10",null,"DNAJC10"]
["19.8548","15.4589",1,1,"14.5224",1,{"$nulls":3},"mRNA processing;RNA splicing;transcription from RNA polymerase II promoter","protein domain specific binding;RNA binding","nucleus",{"$nulls":3},6,6,6,"6.5","6.5","6.5","139.27",0,"14.551",111990000,11,"0.381842",1,"6.59708","0.908278","sp|Q9H7N4|SFR19_HUMAN","sp|Q9H7N4|SFR19_HUMAN",4509,"Q9H7N4","SFR19_HUMAN","Splicing factor, arginine/serine-rich 19",null,"SCAF1"]
["18.7196","17.5985","18.3959",1,"17.1239","16.8183",{"$nulls":3},"androgen receptor signaling pathway;atrial cardiac muscle cell development;heart trabecula formation;negative regulation of apoptotic process;negative regulation of transcription from RNA polymerase II promoter;osteoblast differentiation;positive regulation of transcription, DNA-templated;regulation of lipid metabolic process;response to hormone;transcription, DNA-templated;ventricular cardiac muscle cell development","androgen receptor binding;identical protein binding;metal ion binding;transcription coactivator activity;transcription factor binding","focal adhesion;M band;nucleoplasm;nucleus;Z disc","Osteoclast differentiation",null,null,4,4,4,"17.9","17.9","17.9","32.193",0,"14.91",40290000,4,"0.546246",1,"6.5906","1.23539","sp|Q14192|FHL2_HUMAN;tr|J3KNW4|J3KNW4_HUMAN;tr|A0A0A0MSG2|A0A0A0MSG2_HUMAN","sp|Q14192|FHL2_HUMAN;tr|J3KNW4|J3KNW4_HUMAN;tr|A0A0A0MSG2|A0A0A0MSG2_HUMAN",2452,"Q14192","FHL2_HUMAN","Four and a half LIM domains protein 2","HL-2","FHL2"]
["22.5531","19.9105","19.788","22.3034","19.1815",1,{"$nulls":3},"intracellular protein transport","SNAP receptor activity","intracellular;membrane",{"$nulls":3},2,2,2,"42.3","42.3","42.3","10.509",0,"32.97",49662000,7,"0.418753",1,"6.58892","0.982951","tr|K7EQ84|K7EQ84_HUMAN;tr|K7EPP9|K7EPP9_HUMAN;tr|K7ELY2|K7ELY2_HUMAN;tr|K7EIY4|K7EIY4_HUMAN;tr|Q5U8S2|Q5U8S2_HUMAN;sp|O60499|STX10_HUMAN;tr|K7EJ05|K7EJ05_HUMAN;tr|X6R2W0|X6R2W0_HUMAN","tr|K7EQ84|K7EQ84_HUMAN;tr|K7EPP9|K7EPP9_HUMAN;tr|K7ELY2|K7ELY2_HUMAN;tr|K7EIY4|K7EIY4_HUMAN;tr|Q5U8S2|Q5U8S2_HUMAN;sp|O60499|STX10_HUMAN;tr|K7EJ05|K7EJ05_HUMAN;tr|X6R2W0|X6R2W0_HUMAN",498,"K7EQ84","K7EQ84_HUMAN",null,null,"STX10"]
["20.3668","19.1725","19.7514",1,"17.9738","20.5919",{"$nulls":3},"transcription, DNA-templated","DNA binding;DNA-directed 5'-3' RNA polymerase activity;protein dimerization activity","nucleus",{"$nulls":3},4,4,4,"39.1","39.1","39.1","15.237",0,"9.023",56365000,4,"0.461817",1,"6.57502","1.069","sp|Q9Y2S0|RPAC2_HUMAN;tr|Q7Z776|Q7Z776_HUMAN;tr|A0A087X0U2|A0A087X0U2_HUMAN","sp|Q9Y2S0|RPAC2_HUMAN",5237,"Q9Y2S0","RPAC2_HUMAN","DNA-directed RNA polymerases I and III subunit RPAC2","NA polymerases I and III subunit AC2","POLR1D"]
["20.3822","17.8287",1,1,"17.5148",1,{"$nulls":3},"bone mineralization;inositol phosphate metabolic process;ossification;polyphosphate metabolic process","acid phosphatase activity;bisphosphoglycerate 3-phosphatase activity;inositol hexakisphosphate 2-phosphatase activity;inositol phosphate phosphatase activity;inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity;inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity;protein histidine phosphatase activity","endoplasmic reticulum;endoplasmic reticulum lumen;extracellular exosome","Glycolysis / Gluconeogenesis;Inositol phosphate metabolism;Metabolic pathways",null,null,4,4,4,"12.9","12.9","12.9","55.051",0,"22.579",69038000,8,"0.32949",1,"6.56535","0.800469","sp|Q9UNW1|MINP1_HUMAN","sp|Q9UNW1|MINP1_HUMAN",5163,"Q9UNW1","MINP1_HUMAN","Multiple inositol polyphosphate phosphatase 1 {ECO:0000312|HGNC:HGNC:7102}",null,"MINPP1"]
["19.005","18.1585","16.5776",1,"16.5829","16.4913",{"$nulls":4},"5'-3' exonuclease activity;endonuclease activity;metal ion binding;nucleic acid binding","mitochondrial inner membrane;protein complex",{"$nulls":3},4,4,4,"16.6","16.6","16.6","41.084",0,"13.181",95892000,15,"0.555762",1,"6.55563","1.25401","sp|Q9Y2C4|EXOG_HUMAN;tr|F8WE28|F8WE28_HUMAN;tr|F8WE38|F8WE38_HUMAN;tr|H7C0W6|H7C0W6_HUMAN","sp|Q9Y2C4|EXOG_HUMAN",5217,"Q9Y2C4","EXOG_HUMAN","Nuclease EXOG, mitochondrial",null,"EXOG"]
["18.3204","16.0202","18.3405",1,"15.8093","16.2048",{"$nulls":3},"chitin catabolic process;oligosaccharide catabolic process","chitin binding;chitinase activity","extracellular exosome;extracellular space;lysosome",{"$nulls":3},2,2,2,6,6,6,"43.759","0.00021626","5.1294",18663000,3,"0.576696",1,"6.55562","1.29492","sp|Q01459|DIAC_HUMAN","sp|Q01459|DIAC_HUMAN",2137,"Q01459","DIAC_HUMAN","Di-N-acetylchitobiase",null,"CTBS"]
["20.2899","16.2857","18.6566",1,"16.2893","18.2799",{"$nulls":5},"integral component of membrane;microtubule cytoskeleton;plasma membrane",{"$nulls":3},4,4,4,"24.4","24.4","24.4","29.34",0,"15.628",45330000,8,"0.515167",1,"6.55431","1.17441","sp|Q8IUW5|RELL1_HUMAN;tr|D6RBN9|D6RBN9_HUMAN","sp|Q8IUW5|RELL1_HUMAN;tr|D6RBN9|D6RBN9_HUMAN",3283,"Q8IUW5","RELL1_HUMAN","RELT-like protein 1",null,"RELL1"]
["19.2463","14.302","18.1907",1,"13.6362","17.4422",{"$nulls":3},"aging;cerebellum development;in utero embryonic development;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;response to ethanol;response to hypoxia;response to nicotine","NADH dehydrogenase (ubiquinone) activity","integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I","Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,3,3,3,"8.3","8.3","8.3","51.58",0,"6.0144",17339000,5,"0.559997",1,"6.55357","1.26229","sp|P03905|NU4M_HUMAN","sp|P03905|NU4M_HUMAN",858,"P03905","NU4M_HUMAN","NADH-ubiquinone oxidoreductase chain 4",null,"MT-ND4"]
["12.8854","11.5941","13.4293","16.2668",1,1,{"$nulls":3},"axonogenesis;cellular response to magnesium ion;cytoskeletal anchoring at plasma membrane;ER to Golgi vesicle-mediated transport;establishment of protein localization;Golgi to plasma membrane protein transport;magnesium ion homeostasis;maintenance of protein location in plasma membrane;membrane assembly;mitotic cytokinesis;negative regulation of delayed rectifier potassium channel activity;neuromuscular junction development;neuronal action potential;plasma membrane organization;positive regulation of cation channel activity;positive regulation of cell communication by electrical coupling;positive regulation of gene expression;positive regulation of homotypic cell-cell adhesion;positive regulation of membrane depolarization during cardiac muscle cell action potential;positive regulation of membrane potential;positive regulation of protein targeting to membrane;positive regulation of sodium ion transmembrane transporter activity;positive regulation of sodium ion transport;protein localization to plasma membrane;regulation of potassium ion transport;signal transduction","cadherin binding;cytoskeletal protein binding;ion channel binding;protein binding, bridging;spectrin binding;structural constituent of cytoskeleton","axon initial segment;basolateral plasma membrane;cell surface;costamere;cytosol;dendrite;endoplasmic reticulum;Golgi apparatus;intercalated disc;lateral plasma membrane;lysosome;neuromuscular junction;neuron projection;node of Ranvier;plasma membrane;postsynaptic membrane;sarcolemma;sarcoplasmic reticulum;spectrin-associated cytoskeleton;T-tubule;Z disc","Proteoglycans in cancer",null,null,6,6,5,"1.9","1.9","1.7","480.4",0,"12.215",51220000,6,"0.56869",1,"6.54731","1.27928","sp|Q12955|ANK3_HUMAN;tr|A0A087WTF3|A0A087WTF3_HUMAN;tr|A0A087WUY3|A0A087WUY3_HUMAN;tr|A0A087WZ65|A0A087WZ65_HUMAN;tr|A0A087WWI5|A0A087WWI5_HUMAN;tr|H0YA66|H0YA66_HUMAN;tr|H0YAH5|H0YAH5_HUMAN;tr|A0A087WTE8|A0A087WTE8_HUMAN;tr|D6RHY3|D6RHY3_HUMAN;tr|A0A087WVC2|A0A087WVC2_HUMAN;tr|A0A087X0B4|A0A087X0B4_HUMAN;tr|H0Y3A4|H0Y3A4_HUMAN","sp|Q12955|ANK3_HUMAN;tr|A0A087WTF3|A0A087WTF3_HUMAN;tr|A0A087WUY3|A0A087WUY3_HUMAN;tr|A0A087WZ65|A0A087WZ65_HUMAN",2285,"Q12955","ANK3_HUMAN","Ankyrin-3 {ECO:0000303|PubMed:7836469}","NK-3 {ECO:0000303|PubMed:7836469}","ANK3"]
["18.4636","17.6556",1,1,"15.5303",1,{"$nulls":3},"regulation of transcription, DNA-templated;vesicle-mediated transport","DNA binding;zinc ion binding","Golgi apparatus;integral component of membrane;nucleus",{"$nulls":3},3,3,3,"11.3","11.3","11.3","34.114","0.0084141","2.27",35893000,3,"0.364936",1,"6.52962","0.873732","sp|O95159|ZFPL1_HUMAN;tr|E9PQA5|E9PQA5_HUMAN;tr|E9PQ47|E9PQ47_HUMAN;tr|E9PNY1|E9PNY1_HUMAN;tr|H0YCU8|H0YCU8_HUMAN;tr|E9PMQ3|E9PMQ3_HUMAN","sp|O95159|ZFPL1_HUMAN;tr|E9PQA5|E9PQA5_HUMAN;tr|E9PQ47|E9PQ47_HUMAN;tr|E9PNY1|E9PNY1_HUMAN",715,"O95159","ZFPL1_HUMAN","Zinc finger protein-like 1",null,"ZFPL1"]
["20.2571","21.5156","20.7216",1,"21.2024","20.7225",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},3,3,3,"38.7","38.7","38.7","10.474",0,"9.3209",129890000,12,"0.416592",1,"6.52312","0.978607","tr|D6RAN8|D6RAN8_HUMAN;sp|Q9P0M9|RM27_HUMAN;tr|H7C5U8|H7C5U8_HUMAN","tr|D6RAN8|D6RAN8_HUMAN;sp|Q9P0M9|RM27_HUMAN;tr|H7C5U8|H7C5U8_HUMAN",4910,"D6RAN8","D6RAN8_HUMAN"]
["19.6558","17.3142",1,1,"16.4342",1,{"$nulls":3},"protein folding","peptidyl-prolyl cis-trans isomerase activity",{"$nulls":4},4,4,4,22,22,22,"27.409",0,"10.604",33361000,1,"0.345879",1,"6.51197","0.834493","tr|C9JN15|C9JN15_HUMAN;tr|C9JM79|C9JM79_HUMAN;sp|Q13427|PPIG_HUMAN;tr|E9PG73|E9PG73_HUMAN","tr|C9JN15|C9JN15_HUMAN;tr|C9JM79|C9JM79_HUMAN;sp|Q13427|PPIG_HUMAN;tr|E9PG73|E9PG73_HUMAN",2353,"C9JN15","C9JN15_HUMAN","Peptidyl-prolyl cis-trans isomerase {ECO:0000256|RuleBase:RU363019}","PIase {ECO:0000256|RuleBase:RU363019}","PPIG"]
["20.217",1,"19.5655",1,1,"19.2738",{"$nulls":4},"actin filament binding;calcium ion binding",{"$nulls":4},1,1,1,"10.3","10.3","10.3","11.341","0.00042735","4.868",30389000,2,"0.301682",1,"6.50292","0.742077","tr|Q5JUP3|Q5JUP3_HUMAN;sp|Q9BQI0|AIF1L_HUMAN","tr|Q5JUP3|Q5JUP3_HUMAN;sp|Q9BQI0|AIF1L_HUMAN",4151,"Q5JUP3","Q5JUP3_HUMAN",null,null,"AIF1L"]
["18.4045","18.9966","20.0551",1,"18.1971","18.7848",{"$nulls":3},"glycosaminoglycan catabolic process;heparan sulfate proteoglycan catabolic process","metal ion binding;N-sulfoglucosamine sulfohydrolase activity;sulfuric ester hydrolase activity","extracellular exosome;lysosomal lumen;lysosome","Glycosaminoglycan degradation;Lysosome;Metabolic pathways",null,null,3,3,3,"7.8","7.8","7.8","56.695",0,"19.933",76403000,5,"0.482058",1,"6.49142","1.10913","sp|P51688|SPHM_HUMAN;tr|I3NI22|I3NI22_HUMAN","sp|P51688|SPHM_HUMAN",1753,"P51688","SPHM_HUMAN","N-sulphoglucosamine sulphohydrolase",null,"SGSH"]
["19.8793","19.2769","20.0564",1,"19.1081","19.637",{"$nulls":3},"cellular response to DNA damage stimulus;peptidyl-serine ADP-ribosylation;regulation of protein ADP-ribosylation","histone binding","nucleus",{"$nulls":3},8,8,8,"27.2","27.2","27.2","39.436",0,"13.9",103430000,8,"0.456529",1,"6.48919","1.05849","sp|Q9NWY4|CD027_HUMAN;sp|A8MVJ9|YI028_HUMAN","sp|Q9NWY4|CD027_HUMAN",4802,"Q9NWY4","HPF1_HUMAN","Histone PARylation factor 1 {ECO:0000303|PubMed:27067600, ECO:0000312|HGNC:HGNC:26051}",null,"HPF1"]
["18.9259","18.6858","18.6382",1,"17.2703","18.5989",{"$nulls":4},"oxidoreductase activity","integral component of membrane",{"$nulls":3},2,2,2,"13.3","13.3","13.3","22.62","0.00021654","5.1814",26645000,2,"0.498538",1,"6.46024","1.14167","tr|K7ERC8|K7ERC8_HUMAN;sp|Q06136|KDSR_HUMAN","tr|K7ERC8|K7ERC8_HUMAN;sp|Q06136|KDSR_HUMAN",2201,"K7ERC8","K7ERC8_HUMAN",null,null,"KDSR"]
["19.3744","17.4198",1,1,"16.4332",1,{"$nulls":4},"RNA binding",{"$nulls":4},4,1,1,"12.4","3.7","3.7","43.647","0.006984","2.3258",16994000,2,"0.343862",1,"6.45366","0.830319","tr|A0A0D9SEM4|A0A0D9SEM4_HUMAN;sp|Q08170|SRSF4_HUMAN","tr|A0A0D9SEM4|A0A0D9SEM4_HUMAN;sp|Q08170|SRSF4_HUMAN",2222,"A0A0D9SEM4","A0A0D9SEM4_HUMAN",null,null,"SRSF4"]
["18.6921","17.3344","18.0954","17.9243",1,"15.864",{"$nulls":3},"glutamate metabolic process","D-glutamate cyclase activity","mitochondrial matrix","D-Glutamine and D-glutamate metabolism;Metabolic pathways",null,null,5,5,5,"12.5","12.5","12.5","66.436",0,"15.615",59356000,8,"0.531013",1,"6.44452","1.20553","sp|Q7Z3D6|CN159_HUMAN;tr|H0YB62|H0YB62_HUMAN;tr|H0YB09|H0YB09_HUMAN;tr|H0YB11|H0YB11_HUMAN;tr|A0A0C4DGD4|A0A0C4DGD4_HUMAN","sp|Q7Z3D6|CN159_HUMAN;tr|H0YB62|H0YB62_HUMAN;tr|H0YB09|H0YB09_HUMAN",3153,"Q7Z3D6","GLUCM_HUMAN","D-glutamate cyclase, mitochondrial {ECO:0000305}",null,"DGLUCY"]
["20.2585","14.593","18.719",1,"15.1339","18.1358",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;immune response;interferon-gamma-mediated signaling pathway;regulation of immune response;type I interferon signaling pathway;viral process","peptide antigen binding","cell surface;early endosome membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;integral component of plasma membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},13,4,0,"44.3","18.9",0,"40.885",0,"17.98",63209000,8,"0.507729",1,"6.43362","1.15978","sp|P30508|1C12_HUMAN;sp|Q29960|1C16_HUMAN;sp|P30510|1C14_HUMAN;sp|P04222|1C03_HUMAN;sp|P30501|1C02_HUMAN;tr|A0A0G2JKJ1|A0A0G2JKJ1_HUMAN","sp|P30508|1C12_HUMAN;sp|Q29960|1C16_HUMAN;sp|P30510|1C14_HUMAN;sp|P04222|1C03_HUMAN;sp|P30501|1C02_HUMAN",1385,"P30508","1C12_HUMAN","HLA class I histocompatibility antigen, Cw-12 alpha chain",null,"HLA-C"]
["21.0034",1,"19.0506",1,1,"19.7888",{"$nulls":5},"cytosol;nucleus",{"$nulls":3},1,1,1,"23.3","23.3","23.3","11.852","0.0010042","3.6211",10653000,1,"0.290819",1,"6.42173","0.719017","tr|A0A087WTY9|A0A087WTY9_HUMAN;sp|Q9Y605|MOFA1_HUMAN","tr|A0A087WTY9|A0A087WTY9_HUMAN;sp|Q9Y605|MOFA1_HUMAN",5379,"A0A087WTY9","A0A087WTY9_HUMAN",null,null,"MRFAP1"]
["17.174","18.507",1,1,"15.4215",1,{"$nulls":3},"DNA-templated transcription, initiation;intracellular estrogen receptor signaling pathway;negative regulation of histone acetylation;negative regulation of protein kinase activity;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of transcription from RNA polymerase II promoter;regulation of signal transduction by p53 class mediator;regulation of transcription initiation from RNA polymerase II promoter;RNA polymerase II transcriptional preinitiation complex assembly;spermine transport;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","histone acetyltransferase binding;protein heterodimerization activity;thyroid hormone receptor binding;transcription coactivator activity;transcription factor binding;transcription regulatory region DNA binding;vitamin D receptor binding","Golgi apparatus;MLL1 complex;nucleoplasm;transcription factor complex;transcription factor TFIID complex;transcription factor TFTC complex","Basal transcription factors",null,null,4,4,4,14,14,14,"40.259",0,"9.3579",69528000,11,"0.361887",1,"6.41982","0.867477","sp|Q15545|TAF7_HUMAN","sp|Q15545|TAF7_HUMAN",2612,"Q15545","TAF7_HUMAN","Transcription initiation factor TFIID subunit 7",null,"TAF7"]
["20.0899","16.9351","16.3158",1,"17.1512","15.9356",{"$nulls":3},"asparagine catabolic process via L-aspartate;L-phenylalanine catabolic process","asparaginase activity;beta-aspartyl-peptidase activity","cytoplasm;cytosol;nucleus","Alanine, aspartate and glutamate metabolism;Metabolic pathways",null,null,3,3,3,"18.2","18.2","18.2","32.054",0,"18.688",34830000,5,"0.531125",1,"6.41804","1.20575","sp|Q7L266|ASGL1_HUMAN","sp|Q7L266|ASGL1_HUMAN",3117,"Q7L266","ASGL1_HUMAN","Isoaspartyl peptidase/L-asparaginase",null,"ASRGL1"]
["19.5783","17.4078","17.4822","17.3768","16.8413",1,{"$nulls":3},"epithelial cell differentiation;fructosamine metabolic process;fructoselysine metabolic process;post-translational protein modification","fructosamine-3-kinase activity;kinase activity","cytosol",{"$nulls":3},2,2,2,"9.4","9.4","9.4","35.171","0.00041451","4.2017",29902000,2,"0.520125",1,"6.41672","1.18416","sp|Q9H479|FN3K_HUMAN","sp|Q9H479|FN3K_HUMAN",4458,"Q9H479","FN3K_HUMAN","Fructosamine-3-kinase",null,"FN3K"]
["18.6141","18.5507","19.1716","18.2651","17.8216",1,{"$nulls":3},"cell death;cellular response to tumor necrosis factor;cellular response to virus;inner ear receptor cell differentiation;necrotic cell death;negative regulation of cell proliferation;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of MAPK cascade;pyroptosis;sensory perception of sound","cardiolipin binding;phosphatidylinositol-4,5-bisphosphate binding","cytosol;membrane;plasma membrane",{"$nulls":3},7,7,7,"18.1","18.1","18.1","54.554",0,"25.179",100970000,12,"0.491856",1,"6.41656","1.12849","sp|O60443|DFNA5_HUMAN;tr|H7C3W1|H7C3W1_HUMAN;tr|H7C147|H7C147_HUMAN","sp|O60443|DFNA5_HUMAN;tr|H7C3W1|H7C3W1_HUMAN",494,"O60443","GSDME_HUMAN","Gasdermin-E {ECO:0000305|PubMed:28459430}",null,"GSDME"]
["18.7175","16.5611","16.9409",1,"15.1401","16.8397",{"$nulls":3},"alcohol metabolic process;aldehyde catabolic process;cellular response to oxidative stress;ethanol catabolic process;lipid metabolic process;neutrophil degranulation;oxidation-reduction process;sphingolipid biosynthetic process","3-chloroallyl aldehyde dehydrogenase activity;aldehyde dehydrogenase (NAD) activity;aldehyde dehydrogenase [NAD(P)+] activity","cytoplasm;cytosol;extracellular exosome;plasma membrane;secretory granule membrane;specific granule membrane;vesicle","beta-Alanine metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Glycolysis / Gluconeogenesis;Histidine metabolism;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Phenylalanine metabolism;Tyrosine metabolism",null,null,4,3,3,"11.1","8.5","8.5","51.839","0.00041254","4.1412",33074000,4,"0.562058",1,"6.41324","1.26632","sp|P43353|AL3B1_HUMAN;sp|P48448|AL3B2_HUMAN;tr|A0A087X2D4|A0A087X2D4_HUMAN","sp|P43353|AL3B1_HUMAN;sp|P48448|AL3B2_HUMAN",1572,"P43353","AL3B1_HUMAN","Aldehyde dehydrogenase family 3 member B1",null,"ALDH3B1"]
["19.575","17.2492","19.2568",1,"16.6966","19.183",{"$nulls":5},"nuclear speck;nucleolus;nucleus;plasma membrane",{"$nulls":3},1,1,1,"7.4","7.4","7.4","29.647","0.002305","3.0178",32854000,4,"0.485216",1,"6.40046","1.11537","sp|Q15527|SURF2_HUMAN","sp|Q15527|SURF2_HUMAN",2609,"Q15527","SURF2_HUMAN","Surfeit locus protein 2","urf-2","SURF2"]
["18.2599","16.219","17.3855",1,"15.8209","15.8613",{"$nulls":3},"actin filament bundle assembly;locomotory behavior;negative regulation of cytoskeleton organization;parallel actin filament bundle assembly;positive regulation of filopodium assembly;sensory perception of sound","actin filament binding;SH3 domain binding","brush border;cytoplasm;filamentous actin;microvillus;stereocilium tip",{"$nulls":3},4,4,4,"8.5","8.5","8.5","91.732",0,"11.443",27343000,8,"0.570784",1,"6.39407","1.28337","sp|B1AK53|ESPN_HUMAN;tr|A0A0J9YWQ8|A0A0J9YWQ8_HUMAN;tr|A0A0A0MSQ4|A0A0A0MSQ4_HUMAN;tr|A0A0J9YY76|A0A0J9YY76_HUMAN;tr|H0Y7L4|H0Y7L4_HUMAN","sp|B1AK53|ESPN_HUMAN;tr|A0A0J9YWQ8|A0A0J9YWQ8_HUMAN;tr|A0A0A0MSQ4|A0A0A0MSQ4_HUMAN",194,"B1AK53","ESPN_HUMAN","Espin",null,"ESPN"]
["20.7546","18.5375","19.3089","19.2311",1,"19.2008",{"$nulls":4},"ubiquitin-protein transferase activity","anaphase-promoting complex",{"$nulls":3},1,1,1,"32.4","32.4","32.4","7.4424",0,"11.407",13199000,2,"0.45043",1,"6.38968","1.04635","tr|F8WEU8|F8WEU8_HUMAN;sp|Q9UBF6|RBX2_HUMAN","tr|F8WEU8|F8WEU8_HUMAN;sp|Q9UBF6|RBX2_HUMAN",4955,"F8WEU8","F8WEU8_HUMAN",null,null,"RNF7"]
["20.0678","17.3226",1,1,"17.2389",1,{"$nulls":3},"transmembrane transport",null,"integral component of membrane",{"$nulls":3},1,1,1,"7.9","7.9","7.9","18.967","0.00041374","4.1751",16264000,6,"0.326164",1,"6.38382","0.79353","tr|H3BT44|H3BT44_HUMAN;tr|H3BPQ9|H3BPQ9_HUMAN;sp|Q9H2V7|SPNS1_HUMAN;tr|H3BR82|H3BR82_HUMAN;tr|H3BMF4|H3BMF4_HUMAN","tr|H3BT44|H3BT44_HUMAN;tr|H3BPQ9|H3BPQ9_HUMAN;sp|Q9H2V7|SPNS1_HUMAN;tr|H3BR82|H3BR82_HUMAN;tr|H3BMF4|H3BMF4_HUMAN",4439,"H3BT44","H3BT44_HUMAN",null,null,"SPNS1"]
["17.9544",1,"17.6152",1,1,"15.4824",{"$nulls":3},"canonical glycolysis;galactose catabolic process;glycogen biosynthetic process;glycogen catabolic process","glucose-1,6-bisphosphate synthase activity;metal ion binding;phosphoglucomutase activity","cytosol","Metabolic pathways;Starch and sucrose metabolism",null,null,3,3,3,"6.6","6.6","6.6","70.441",0,"5.4895",28158000,5,"0.358689",1,"6.3624","0.860906","sp|Q6PCE3|PGM2L_HUMAN","sp|Q6PCE3|PGM2L_HUMAN",3025,"Q6PCE3","PGM2L_HUMAN","Glucose 1,6-bisphosphate synthase",null,"PGM2L1"]
["16.5511","17.5178","16.4577","14.4105","16.0674",1,{"$nulls":4},"aminopeptidase activity;manganese ion binding;metalloexopeptidase activity","cytoplasm;nucleus",{"$nulls":3},2,2,2,"6.7","6.7","6.7","55.86",0,"15.246",21139000,4,"0.5935",1,"6.34959","1.32771","sp|Q8NDH3|PEPL1_HUMAN","sp|Q8NDH3|PEPL1_HUMAN",3482,"Q8NDH3","PEPL1_HUMAN","Probable aminopeptidase NPEPL1",null,"NPEPL1"]
["20.664","17.9603","19.0646","19.2893","18.3709",1,{"$nulls":3},"cell differentiation;cell redox homeostasis;negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway","peptide disulfide oxidoreductase activity;protein-disulfide reductase (glutathione) activity","endoplasmic reticulum lumen","Glutathione metabolism;Metabolic pathways",null,null,6,6,6,"53.5","53.5","53.5","19.206",0,"11.201",51310000,8,"0.455783",1,"6.34288","1.057","sp|O95881|TXD12_HUMAN","sp|O95881|TXD12_HUMAN",804,"O95881","TXD12_HUMAN","Thioredoxin domain-containing protein 12",null,"TXNDC12"]
["18.1212","17.1339",1,1,"15.2674",1,{"$nulls":4},"symporter activity","integral component of membrane",{"$nulls":3},1,1,1,"2.8","2.8","2.8","47.099","0.0010121","3.7329",34894000,2,"0.361156",1,"6.32922","0.865974","tr|A0A087X0U3|A0A087X0U3_HUMAN;tr|A0A087WT87|A0A087WT87_HUMAN;sp|P43003|EAA1_HUMAN","tr|A0A087X0U3|A0A087X0U3_HUMAN;tr|A0A087WT87|A0A087WT87_HUMAN;sp|P43003|EAA1_HUMAN",1563,"A0A087X0U3","A0A087X0U3_HUMAN","Amino acid transporter {ECO:0000256|RuleBase:RU361216}",null,"SLC1A3"]
["20.3673","17.3638","18.2624","19.7149","16.3051",1,{"$nulls":4},"metal ion transmembrane transporter activity","membrane",{"$nulls":3},2,2,2,"18.9","18.9","18.9","19.293",0,"8.0283",67410000,8,"0.470427",1,"6.32454","1.08609","tr|J3QLB2|J3QLB2_HUMAN;tr|J3KRX2|J3KRX2_HUMAN;tr|J3QS49|J3QS49_HUMAN;sp|Q8N1S5|S39AB_HUMAN;tr|A0A0J9YXZ0|A0A0J9YXZ0_HUMAN;tr|A0A0J9YXE3|A0A0J9YXE3_HUMAN;tr|J3QQP1|J3QQP1_HUMAN;tr|J3QRN3|J3QRN3_HUMAN;tr|A0A0J9YXX3|A0A0J9YXX3_HUMAN;tr|J3KS66|J3KS66_HUMAN;tr|J3QLA9|J3QLA9_HUMAN","tr|J3QLB2|J3QLB2_HUMAN;tr|J3KRX2|J3KRX2_HUMAN;tr|J3QS49|J3QS49_HUMAN;sp|Q8N1S5|S39AB_HUMAN;tr|A0A0J9YXZ0|A0A0J9YXZ0_HUMAN;tr|A0A0J9YXE3|A0A0J9YXE3_HUMAN;tr|J3QQP1|J3QQP1_HUMAN;tr|J3QRN3|J3QRN3_HUMAN;tr|A0A0J9YXX3|A0A0J9YXX3_HUMAN;tr|J3KS66|J3KS66_HUMAN;tr|J3QLA9|J3QLA9_HUMAN",3380,"J3QLB2","J3QLB2_HUMAN",null,null,"SLC39A11"]
["17.2715","17.4605","17.4368","15.8674","16.3468",1,{"$nulls":3},"DNA repair;global genome nucleotide-excision repair;intra-S DNA damage checkpoint;mismatch repair;nucleotide-excision repair;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, preincision complex assembly;regulation of mitotic cell cycle phase transition;response to auditory stimulus;response to drug;response to UV-B;UV-damage excision repair","bubble DNA binding;damaged DNA binding;heteroduplex DNA loop binding;single-stranded DNA binding","cytoplasm;extracellular exosome;intracellular membrane-bounded organelle;mitochondrion;nucleolus;nucleoplasm;nucleotide-excision repair factor 2 complex;nucleus;plasma membrane;XPC complex","Nucleotide excision repair",null,null,14,14,14,"22.3","22.3","22.3","105.95",0,"150.37",392320000,51,"0.555815",1,"6.31818","1.25411","sp|Q01831|XPC_HUMAN;tr|E7EUB5|E7EUB5_HUMAN","sp|Q01831|XPC_HUMAN",2147,"Q01831","XPC_HUMAN","DNA repair protein complementing XP-C cells",null,"XPC"]
["18.6912","17.1512","17.065",1,"16.1685","16.8106",{"$nulls":3},"mRNA splicing, via spliceosome","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;spliceosomal complex",{"$nulls":3},4,4,4,"7.3","7.3","7.3","88.559",0,"9.12",57356000,9,"0.535775",1,"6.30938","1.21487","sp|Q8IX18|DHX40_HUMAN;tr|J3KSW6|J3KSW6_HUMAN;tr|J3KSX9|J3KSX9_HUMAN;tr|J3KS08|J3KS08_HUMAN;tr|J3KTK0|J3KTK0_HUMAN;tr|F5H625|F5H625_HUMAN","sp|Q8IX18|DHX40_HUMAN;tr|J3KSW6|J3KSW6_HUMAN;tr|J3KSX9|J3KSX9_HUMAN",3316,"Q8IX18","DHX40_HUMAN","Probable ATP-dependent RNA helicase DHX40",null,"DHX40"]
["18.1407","18.0045",1,1,"16.2292",1,{"$nulls":3},"cellular response to calcium ion",null,"cytoplasm;extracellular exosome;nucleus;plasma membrane",{"$nulls":3},6,5,5,"11.9","10.2","10.2","61.189",0,"8.0909",31423000,4,"0.342167",1,"6.30533","0.82681","sp|Q96FN4|CPNE2_HUMAN;tr|H3BPR8|H3BPR8_HUMAN;tr|H3BUC8|H3BUC8_HUMAN","sp|Q96FN4|CPNE2_HUMAN",3877,"Q96FN4","CPNE2_HUMAN","Copine-2 {ECO:0000305}",null,"CPNE2"]
["17.8204","17.484","17.8394","16.989","16.2821",1,{"$nulls":4},"actin filament binding;metal ion binding","actin cytoskeleton",{"$nulls":3},14,1,1,"49.1","3.6","3.6","47.401",0,"6.7525",37706000,5,"0.531157",1,"6.2909","1.20582","tr|H0Y704|H0Y704_HUMAN","tr|H0Y704|H0Y704_HUMAN",5565,"H0Y704","H0Y704_HUMAN",null,null,"ZNF185"]
["19.326","19.2308",1,1,"18.7057",1,{"$nulls":3},"plasma membrane ATP synthesis coupled electron transport;respiratory chain complex IV assembly","copper ion binding;RNA binding","mitochondrial intermembrane space;mitochondrion;plasma membrane","Thermogenesis",null,null,2,2,2,"21.6","21.6","21.6","14.116",0,"6.9391",61191000,5,"0.301066",1,"6.28371","0.740773","sp|Q5JTJ3|COA6_HUMAN;tr|X6R5Z6|X6R5Z6_HUMAN","sp|Q5JTJ3|COA6_HUMAN;tr|X6R5Z6|X6R5Z6_HUMAN",2828,"Q5JTJ3","COA6_HUMAN","Cytochrome c oxidase assembly factor 6 homolog",null,"COA6"]
[1,"19.2923","19.4741",1,1,"18.9896",{"$nulls":3},"cytidine to uridine editing","RNA binding",{"$nulls":4},1,1,1,"33.9","33.9","33.9","5.9175","0.0023037","3.0159",11087000,1,"0.295986",1,"6.25893","0.730005","tr|D6RCT1|D6RCT1_HUMAN;tr|D6RBP6|D6RBP6_HUMAN;tr|D6RA49|D6RA49_HUMAN;tr|D6RFL5|D6RFL5_HUMAN;tr|D6R9M7|D6R9M7_HUMAN;tr|D6REZ6|D6REZ6_HUMAN;tr|D6RBS9|D6RBS9_HUMAN;tr|D6R9D6|D6R9D6_HUMAN;sp|A0AV96|RBM47_HUMAN","tr|D6RCT1|D6RCT1_HUMAN;tr|D6RBP6|D6RBP6_HUMAN;tr|D6RA49|D6RA49_HUMAN;tr|D6RFL5|D6RFL5_HUMAN;tr|D6R9M7|D6R9M7_HUMAN;tr|D6REZ6|D6REZ6_HUMAN;tr|D6RBS9|D6RBS9_HUMAN;tr|D6R9D6|D6R9D6_HUMAN;sp|A0AV96|RBM47_HUMAN",163,"D6RCT1","D6RCT1_HUMAN",null,null,"RBM47"]
["17.8083","16.4248",1,1,"14.4902",1,{"$nulls":3},"cell proliferation;cell surface receptor signaling pathway;cell-cell adhesion;negative regulation of branching involved in ureteric bud morphogenesis;negative regulation of cell motility;negative regulation of epithelial cell migration;negative regulation of ruffle assembly;negative regulation of stress fiber assembly;negative regulation of substrate adhesion-dependent cell spreading;positive regulation of stem cell differentiation;regulation of epithelial cell proliferation;ureteric bud morphogenesis;visual perception","receptor activity","basal plasma membrane;cytosol;extracellular exosome;extracellular space;integral component of plasma membrane;lateral plasma membrane;membrane;nucleus",{"$nulls":3},1,1,1,5,5,5,"35.709","0.0053853","2.4789",9467300,1,"0.373046",1,"6.24761","0.890334","sp|P09758|TACD2_HUMAN","sp|P09758|TACD2_HUMAN",999,"P09758","TACD2_HUMAN","Tumor-associated calcium signal transducer 2",null,"TACSTD2"]
["18.8881","15.7066","15.3704",1,"15.1558","15.1253",{"$nulls":3},"negative regulation of DNA binding transcription factor activity;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;proteasome-mediated ubiquitin-dependent protein catabolic process;protein polyubiquitination;protein ubiquitination;random inactivation of X chromosome;regulation of dosage compensation by inactivation of X chromosome;transcription, DNA-templated;ubiquitin-dependent protein catabolic process","metal ion binding;transcription corepressor activity;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytosol;nucleoplasm;nucleus;transcriptional repressor complex",{"$nulls":3},2,2,2,"4.6","4.6","4.6","68.548","0.0011993","3.5605",26244000,2,"0.571851",1,"6.22797","1.28546","sp|Q9NVW2|RNF12_HUMAN","sp|Q9NVW2|RNF12_HUMAN",4779,"Q9NVW2","RNF12_HUMAN","E3 ubiquitin-protein ligase RLIM",null,"RLIM"]
["19.3888","18.311",1,"18.0626",1,1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"5.3","5.3","5.3","27.55","0.00041876","4.4087",25688000,4,"0.307429",1,"6.21243","0.754217","sp|Q5SWH9|TMM69_HUMAN","sp|Q5SWH9|TMM69_HUMAN",2854,"Q5SWH9","TMM69_HUMAN","Transmembrane protein 69",null,"TMEM69"]
["17.5258","20.9341","19.1314",1,"20.413","17.5522",{"$nulls":5},"mitochondrion",{"$nulls":3},3,3,3,"19.6","19.6","19.6","12.114",0,"9.3107",62112000,5,"0.433624",1,"6.20873","1.01278","sp|Q53S33|BOLA3_HUMAN","sp|Q53S33|BOLA3_HUMAN",2789,"Q53S33","BOLA3_HUMAN","BolA-like protein 3 {ECO:0000305}",null,"BOLA3"]
["18.7728","18.6028",1,1,"17.7516",1,{"$nulls":3},"cell cycle;cell division;mRNA splicing, via spliceosome;RNA splicing, via transesterification reactions;spliceosomal complex assembly",null,"cytosol;nuclear membrane;nucleoplasm;nucleus;spliceosomal complex;U4/U6 x U5 tri-snRNP complex;U5 snRNP","Spliceosome",null,null,2,2,2,"16.2","16.2","16.2","16.786","0.00041494","4.2143",21960000,3,"0.312299",1,"6.20799","0.764475","sp|P83876|TXN4A_HUMAN;tr|K7EPA6|K7EPA6_HUMAN;tr|K7EJU2|K7EJU2_HUMAN;tr|K7ESL1|K7ESL1_HUMAN;tr|K7EMX5|K7EMX5_HUMAN;tr|O14835|O14835_HUMAN;tr|K7ES07|K7ES07_HUMAN","sp|P83876|TXN4A_HUMAN;tr|K7EPA6|K7EPA6_HUMAN;tr|K7EJU2|K7EJU2_HUMAN;tr|K7ESL1|K7ESL1_HUMAN;tr|K7EMX5|K7EMX5_HUMAN;tr|O14835|O14835_HUMAN;tr|K7ES07|K7ES07_HUMAN",2091,"P83876","TXN4A_HUMAN","Thioredoxin-like protein 4A",null,"TXNL4A"]
[1,"19.3115","18.9885",1,1,"18.7321",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;mRNA processing;negative regulation of mitotic nuclear division;positive regulation of proteolysis",null,"intracellular membrane-bounded organelle;mitochondrial inner membrane;mitochondrion;nucleoplasm;nucleus;ribosome",{"$nulls":3},1,1,1,5,5,5,"22.354","0.0058997","2.3851",186070000,5,"0.296794",1,"6.1893","0.731719","sp|Q9NWT8|AKIP_HUMAN","sp|Q9NWT8|AKIP_HUMAN",4796,"Q9NWT8","AKIP_HUMAN","Aurora kinase A-interacting protein","URKA-interacting protein","AURKAIP1"]
["18.2102","16.6684",1,1,"15.3133",1,{"$nulls":4},"RNA binding","nucleolus",{"$nulls":3},3,3,3,"8.1","8.1","8.1","51.588","0.00041675","4.3162",47983000,6,"0.353455",1,"6.18844","0.850133","sp|Q1ED39|KNOP1_HUMAN;tr|H3BPL4|H3BPL4_HUMAN","sp|Q1ED39|KNOP1_HUMAN;tr|H3BPL4|H3BPL4_HUMAN",2709,"Q1ED39","KNOP1_HUMAN","Lysine-rich nucleolar protein 1",null,"KNOP1"]
["18.8343","17.8352","17.063",1,"17.4871","16.7276",{"$nulls":3},"N-terminal peptidyl-methionine acetylation","peptide alpha-N-acetyltransferase activity","cytoplasm;cytosol;NatC complex;nucleus",{"$nulls":3},5,5,5,"22.7","22.7","22.7","39.319",0,"13.366",49085000,12,"0.499465",1,"6.1726","1.1435","sp|Q147X3|NAA30_HUMAN;tr|J3KNC2|J3KNC2_HUMAN","sp|Q147X3|NAA30_HUMAN",2509,"Q147X3","NAA30_HUMAN","N-alpha-acetyltransferase 30",null,"NAA30"]
["19.8494",1,"19.2507",1,1,"19.5837",{"$nulls":3},"rRNA processing;tRNA 5'-leader removal","ribonuclease P activity;RNA binding","multimeric ribonuclease P complex;nucleoplasm;nucleus","RNA transport",null,null,3,3,3,"36.3","36.3","36.3","13.693",0,"26.272",60113000,13,"0.284273",1,"6.17214","0.705048","sp|O95059|RPP14_HUMAN","sp|O95059|RPP14_HUMAN",707,"O95059","RPP14_HUMAN","Ribonuclease P protein subunit p14",null,"RPP14"]
["19.4133","15.1894",1,1,"15.0892",1,{"$nulls":4},"extracellularly glutamate-gated ion channel activity;ionotropic glutamate receptor activity","cell junction;integral component of membrane;postsynaptic membrane",{"$nulls":3},1,1,1,"2.2","2.2","2.2","82.108","0.0057206","2.3912",39980000,1,"0.351996",1,"6.17116","0.847123","tr|F8W7L6|F8W7L6_HUMAN;sp|P42262|GRIA2_HUMAN","tr|F8W7L6|F8W7L6_HUMAN;sp|P42262|GRIA2_HUMAN",1546,"F8W7L6","F8W7L6_HUMAN",null,null,"GRIA2"]
["19.5266",1,"19.2223",1,1,"19.2379",{"$nulls":4},"GTPase activator activity","cytosol;Golgi apparatus;plasma membrane",{"$nulls":3},3,1,1,"13.1","4.4","4.4","27.131","0.0041206","2.6225",32765000,1,"0.288921",1,"6.17031","0.714973","tr|E9PN48|E9PN48_HUMAN","tr|E9PN48|E9PN48_HUMAN",5521,"E9PN48","E9PN48_HUMAN",null,null,"ARFGAP2"]
["20.7657",1,"20.2963",1,1,"21.5612",{"$nulls":9},2,2,2,"38.9","38.9","38.9","7.8036","0.0011874","3.424",68148000,5,"0.259806",1,"6.16691","0.652313","tr|S4R329|S4R329_HUMAN;tr|H0YK61|H0YK61_HUMAN;tr|H0YNK0|H0YNK0_HUMAN;tr|H0YNK8|H0YNK8_HUMAN;tr|H0YLP8|H0YLP8_HUMAN;sp|Q5J8M3|EMC4_HUMAN","tr|S4R329|S4R329_HUMAN;tr|H0YK61|H0YK61_HUMAN;tr|H0YNK0|H0YNK0_HUMAN;tr|H0YNK8|H0YNK8_HUMAN;tr|H0YLP8|H0YLP8_HUMAN;sp|Q5J8M3|EMC4_HUMAN",2819,"S4R329","S4R329_HUMAN",null,null,"EMC4"]
["17.8266","18.9621","18.6646","18.0348",1,"17.9243",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;endosomal transport;retrograde transport, endosome to Golgi","actin binding;alpha-tubulin binding","cytosol;early endosome;early endosome membrane;recycling endosome;recycling endosome membrane;WASH complex",{"$nulls":3},1,1,1,"3.8","3.8","3.8","47.989",0,"19.763",36976000,8,"0.470999",1,"6.16472","1.08723","sp|Q9NQA3|WASH6_HUMAN","sp|Q9NQA3|WASH6_HUMAN",4653,"Q9NQA3","WASH6_HUMAN","WAS protein family homolog 6",null,"WASH6P"]
[1,"17.3474","17.7637",1,"15.6259",1,{"$nulls":3},"calcium ion-regulated exocytosis of neurotransmitter;exocytosis;intracellular protein transport;regulation of calcium ion-dependent exocytosis;vesicle fusion","calcium ion binding;calcium-dependent phospholipid binding;clathrin binding;neurexin family protein binding;Rab GTPase binding;syntaxin binding","exocytic vesicle;extracellular exosome;extrinsic component of plasma membrane;melanosome;microvillus membrane;plasma membrane;presynapse",{"$nulls":3},7,7,7,"17.3","17.3","17.3","61.856",0,"12.486",71005000,12,"0.346933",1,"6.16174","0.836671","sp|Q8IYJ3|SYTL1_HUMAN;tr|A0A087X1N4|A0A087X1N4_HUMAN","sp|Q8IYJ3|SYTL1_HUMAN;tr|A0A087X1N4|A0A087X1N4_HUMAN",3341,"Q8IYJ3","SYTL1_HUMAN","Synaptotagmin-like protein 1",null,"SYTL1"]
["19.9254","21.322","18.2222",1,"19.8619","20.1317",{"$nulls":3},"purine nucleobase metabolic process;purine nucleotide metabolic process","GMP reductase activity;metal ion binding","GMP reductase complex",{"$nulls":3},4,4,4,"14.9","14.9","14.9","33.921",0,"7.7828",130740000,9,"0.408802",1,"6.15866","0.962913","tr|H0YMB3|H0YMB3_HUMAN;tr|H0YLV5|H0YLV5_HUMAN;tr|A0A087WWM4|A0A087WWM4_HUMAN;sp|Q9P2T1|GMPR2_HUMAN;tr|F8WAN9|F8WAN9_HUMAN;tr|H0YNJ6|H0YNJ6_HUMAN;tr|H0YLB8|H0YLB8_HUMAN;tr|H0YK13|H0YK13_HUMAN;tr|H0YNS9|H0YNS9_HUMAN;tr|H0YK71|H0YK71_HUMAN;tr|H0YL68|H0YL68_HUMAN;tr|H0YKE1|H0YKE1_HUMAN;tr|H0YMR9|H0YMR9_HUMAN;tr|H0YMV5|H0YMV5_HUMAN;tr|H0YNH0|H0YNH0_HUMAN","tr|H0YMB3|H0YMB3_HUMAN;tr|H0YLV5|H0YLV5_HUMAN;tr|A0A087WWM4|A0A087WWM4_HUMAN;sp|Q9P2T1|GMPR2_HUMAN;tr|F8WAN9|F8WAN9_HUMAN;tr|H0YNJ6|H0YNJ6_HUMAN;tr|H0YLB8|H0YLB8_HUMAN;tr|H0YK13|H0YK13_HUMAN;tr|H0YNS9|H0YNS9_HUMAN;tr|H0YK71|H0YK71_HUMAN",4941,"H0YMB3","H0YMB3_HUMAN","GMP reductase {ECO:0000256|HAMAP-Rule:MF_03195}","MPR {ECO:0000256|HAMAP-Rule:MF_03195}","GMPR2"]
["18.851","17.9346","18.8941",1,"17.6662","18.5511",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","cytosolic small ribosomal subunit;mitochondrial inner membrane;mitochondrial small ribosomal subunit","Ribosome",null,null,3,3,3,"17.9","17.9","17.9","22.184","0.00021584","5.0872",54660000,3,"0.465563",1,"6.15418","1.07644","sp|Q9NVS2|RT18A_HUMAN;tr|Q5QPA5|Q5QPA5_HUMAN","sp|Q9NVS2|RT18A_HUMAN;tr|Q5QPA5|Q5QPA5_HUMAN",4772,"Q9NVS2","RT18A_HUMAN","39S ribosomal protein S18a, mitochondrial","18mt-a;rps18a;RP-S18-a","MRPS18A"]
["18.9619","16.4074","17.5331","17.4089","16.0741",1,{"$nulls":3},"inflammatory response;intracellular signal transduction;negative regulation of apoptotic process;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of apoptotic process;positive regulation of CREB transcription factor activity;positive regulation of neuron projection development;positive regulation of neutrophil chemotaxis;positive regulation of phagocytosis;positive regulation of respiratory burst;regulation of dendrite development;regulation of granulocyte chemotaxis","ATP binding;calmodulin binding;calmodulin-dependent protein kinase activity","cytoplasm;nucleus","Aldosterone synthesis and secretion;Calcium signaling pathway;Glioma;Oxytocin signaling pathway",null,null,3,3,3,"10.6","10.6","10.6","42.913",0,"6.1837",34802000,5,"0.505619",1,"6.13978","1.15562","sp|Q8IU85|KCC1D_HUMAN;tr|A0A087WUR6|A0A087WUR6_HUMAN;tr|H7C071|H7C071_HUMAN;sp|Q14012|KCC1A_HUMAN","sp|Q8IU85|KCC1D_HUMAN;tr|A0A087WUR6|A0A087WUR6_HUMAN",3274,"Q8IU85","KCC1D_HUMAN","Calcium/calmodulin-dependent protein kinase type 1D",null,"CAMK1D"]
["21.0101","17.2558","18.3644",1,"18.9659","18.2562",{"$nulls":9},4,4,4,"39.4","39.4","39.4","13.847",0,"6.6651",55493000,4,"0.440407",1,"6.13608","1.02635","tr|A6NCC9|A6NCC9_HUMAN;tr|E9PME3|E9PME3_HUMAN;tr|C9JHT9|C9JHT9_HUMAN;tr|C9JJV1|C9JJV1_HUMAN;sp|Q9Y5U2|TSSC4_HUMAN;tr|E9PL88|E9PL88_HUMAN;tr|C9JDU0|C9JDU0_HUMAN","tr|A6NCC9|A6NCC9_HUMAN;tr|E9PME3|E9PME3_HUMAN;tr|C9JHT9|C9JHT9_HUMAN;tr|C9JJV1|C9JJV1_HUMAN;sp|Q9Y5U2|TSSC4_HUMAN",5369,"A6NCC9","A6NCC9_HUMAN",null,null,"TSSC4"]
["18.7974","18.0862","17.3083",1,"17.354","17.4947",{"$nulls":9},1,1,1,"5.2","5.2","5.2","34.647","0.0011945","3.4985",19106000,1,"0.484209",1,"6.11444","1.11338","tr|Q5T063|Q5T063_HUMAN;sp|Q9NZJ6|COQ3_HUMAN","tr|Q5T063|Q5T063_HUMAN;sp|Q9NZJ6|COQ3_HUMAN",4876,"Q5T063"]
["19.2529",1,"19.143",1,1,"19.0765",{"$nulls":3},"cellular protein modification process;methionine metabolic process;protein repair;response to oxidative stress","peptide-methionine (S)-S-oxide reductase activity","actin cytoskeleton;cytosol;extracellular exosome;membrane;mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,14,14,14,"26.132",0,"7.2493",26347000,5,"0.288557",1,"6.10644","0.714197","sp|Q9UJ68|MSRA_HUMAN","sp|Q9UJ68|MSRA_HUMAN",5056,"Q9UJ68","MSRA_HUMAN","Mitochondrial peptide methionine sulfoxide reductase",null,"MSRA"]
["20.0385","17.614","17.4322","18.33","17.4367",1,{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA processing;mRNA splice site selection;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;response to alkaloid;response to toxic substance;RNA export from nucleus;termination of RNA polymerase II transcription","protein domain specific binding;RNA binding","nucleolus;nucleoplasm","Herpes simplex virus 1 infection;Spliceosome",null,null,7,7,7,"36.7","36.7","36.7","25.542",0,"17.473",105740000,16,"0.463316",1,"6.10598","1.07198","sp|Q13242|SRSF9_HUMAN;tr|H0YIB4|H0YIB4_HUMAN;tr|S4R3G0|S4R3G0_HUMAN","sp|Q13242|SRSF9_HUMAN;tr|H0YIB4|H0YIB4_HUMAN;tr|S4R3G0|S4R3G0_HUMAN",2328,"Q13242","SRSF9_HUMAN","Serine/arginine-rich splicing factor 9",null,"SRSF9"]
["19.3025",1,"17.8956",1,1,"17.8984",{"$nulls":3},"aerobic respiration;mitochondrial fission",null,"mitochondrion",{"$nulls":3},3,3,3,"17.8","17.8","17.8","31.957",0,"8.0222",19961000,5,"0.305006",1,"6.09992","0.749104","sp|Q9H019|MFR1L_HUMAN;tr|C9JF50|C9JF50_HUMAN;tr|E9PPF9|E9PPF9_HUMAN;tr|E9PLU1|E9PLU1_HUMAN;tr|E9PRK5|E9PRK5_HUMAN;tr|E9PLD2|E9PLD2_HUMAN;tr|E9PPQ0|E9PPQ0_HUMAN;tr|E9PRW1|E9PRW1_HUMAN;tr|E9PSD6|E9PSD6_HUMAN","sp|Q9H019|MFR1L_HUMAN;tr|C9JF50|C9JF50_HUMAN;tr|E9PPF9|E9PPF9_HUMAN;tr|E9PLU1|E9PLU1_HUMAN;tr|E9PRK5|E9PRK5_HUMAN;tr|E9PLD2|E9PLD2_HUMAN",4375,"Q9H019","MFR1L_HUMAN","Mitochondrial fission regulator 1-like",null,"MTFR1L"]
["18.569","18.3192","18.2547",1,"17.7525","18.0925",{"$nulls":3},"beta-catenin-TCF complex assembly;brain development;canonical Wnt signaling pathway;developmental growth;in utero embryonic development;kidney development;lens development in camera-type eye;mammary gland development;palate development;positive regulation of chromatin binding;post-embryonic development;regulation of histone H3-K4 methylation;regulation of mammary gland epithelial cell proliferation;spermatid nucleus differentiation","chromatin binding;histone acetyltransferase regulator activity;histone binding;metal ion binding","nucleoplasm",{"$nulls":3},2,2,2,"8.1","8.1","8.1","41.244","0.001183","3.3513",28323000,4,"0.46784",1,"6.09931","1.08096","sp|Q9BRQ0|PYGO2_HUMAN;tr|Q5T171|Q5T171_HUMAN","sp|Q9BRQ0|PYGO2_HUMAN;tr|Q5T171|Q5T171_HUMAN",4167,"Q9BRQ0","PYGO2_HUMAN","Pygopus homolog 2",null,"PYGO2"]
["20.1107","18.6136","18.8528","19.7199","18.5866",1,{"$nulls":4},"nucleic acid binding",{"$nulls":4},2,2,2,"9.6","9.6","9.6","27.374",0,"5.896",45965000,4,"0.428275",1,"6.09024","1.00207","tr|F6UGJ8|F6UGJ8_HUMAN;sp|O43414|ERI3_HUMAN;tr|F6QUN3|F6QUN3_HUMAN;tr|H0Y4B0|H0Y4B0_HUMAN","tr|F6UGJ8|F6UGJ8_HUMAN;sp|O43414|ERI3_HUMAN;tr|F6QUN3|F6QUN3_HUMAN;tr|H0Y4B0|H0Y4B0_HUMAN",418,"F6UGJ8","F6UGJ8_HUMAN",null,null,"ERI3"]
["18.017","16.9715","17.5421",1,"15.4943","17.7671",{"$nulls":3},"cornification;positive regulation of sodium ion transport","endopeptidase activity;serine-type endopeptidase activity;serine-type peptidase activity;sodium channel regulator activity","anchored component of plasma membrane;extracellular exosome;extracellular region;extracellular space;extrinsic component of plasma membrane;integral component of membrane;plasma membrane",{"$nulls":3},2,2,2,"7.6","7.6","7.6","36.431","0.00042096","4.5397",16861000,1,"0.506684",1,"6.08971","1.15772","sp|Q16651|PRSS8_HUMAN;tr|H3BVC8|H3BVC8_HUMAN;tr|H3BUJ8|H3BUJ8_HUMAN","sp|Q16651|PRSS8_HUMAN;tr|H3BVC8|H3BVC8_HUMAN;tr|H3BUJ8|H3BUJ8_HUMAN",2684,"Q16651","PRSS8_HUMAN","Prostasin",null,"PRSS8"]
["18.9293","16.8805","17.4565","17.8684","16.144",1,{"$nulls":3},"positive regulation of transcription from RNA polymerase II promoter;post-translational protein modification;protein ubiquitination","ligand-dependent nuclear receptor transcription coactivator activity","Cul4-RING E3 ubiquitin ligase complex;cytosol;focal adhesion;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"5.8","5.8","5.8","96.291",0,"8.1808",54289000,6,"0.491714",1,"6.08463","1.12821","sp|Q58WW2|DCAF6_HUMAN","sp|Q58WW2|DCAF6_HUMAN",2799,"Q58WW2","DCAF6_HUMAN","DDB1- and CUL4-associated factor 6",null,"DCAF6"]
["17.8823","18.4449","17.2765",1,"17.8091","16.5465",{"$nulls":9},3,3,3,"24.8","24.8","24.8","13.303",0,"6.4051",75316000,8,"0.489189",1,"6.08271","1.12322","tr|A0A087WYP2|A0A087WYP2_HUMAN;sp|Q8IZQ5|SELH_HUMAN;tr|H0YE28|H0YE28_HUMAN","tr|A0A087WYP2|A0A087WYP2_HUMAN;sp|Q8IZQ5|SELH_HUMAN;tr|H0YE28|H0YE28_HUMAN",3360,"A0A087WYP2","A0A087WYP2_HUMAN",null,null,"SELENOH"]
["18.2782","21.4004","19.5056",1,"20.4797","19.4581",{"$nulls":3},"IRE1-mediated unfolded protein response;protein targeting to ER","P-P-bond-hydrolysis-driven protein transmembrane transporter activity;protein transporter activity","cytosol;endoplasmic reticulum membrane;integral component of membrane;membrane","Phagosome;Protein export;Protein processing in endoplasmic reticulum;Vibrio cholerae infection",null,null,1,1,1,"17.6","17.6","17.6","7.7412",0,"9.2334",71725000,0,"0.402961",1,"6.08209","0.951121","sp|P60059|SC61G_HUMAN","sp|P60059|SC61G_HUMAN",1888,"P60059","SC61G_HUMAN","Protein transport protein Sec61 subunit gamma",null,"SEC61G"]
["19.6324","16.2629",1,1,"16.6549",1,{"$nulls":3},"negative regulation of lipid kinase activity;negative regulation of protein localization to plasma membrane;positive regulation of protein dephosphorylation;protein dephosphorylation;signal transduction","kinase binding;phosphoprotein phosphatase activity;protein phosphatase regulator activity","centrosome;chromosome, centromeric region;cytoplasm;cytosol;M band;nucleus;protein phosphatase type 2A complex;Z disc","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Dopaminergic synapse;Human papillomavirus infection;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway",null,null,5,5,4,"11.5","11.5","9.9","56.193","0.0011802","3.3118",36526000,4,"0.321772",1,"6.08012","0.784348","sp|Q15172|2A5A_HUMAN","sp|Q15172|2A5A_HUMAN",2568,"Q15172","2A5A_HUMAN","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform",null,"PPP2R5A"]
["18.3412","19.8051","17.5332",1,"18.6951","17.7504",{"$nulls":3},"dendrite morphogenesis;lysosomal transport;lysosome localization;lysosome organization;positive regulation of dendrite development",null,"endosome;extracellular exosome;integral component of membrane;late endosome membrane;lysosomal membrane;lysosome",{"$nulls":3},3,3,3,"13.5","13.5","13.5","31.127",0,"6.1582",41015000,3,"0.452525",1,"6.078","1.05052","sp|Q9NUM4|T106B_HUMAN;tr|C9JZ87|C9JZ87_HUMAN;tr|F2Z3N7|F2Z3N7_HUMAN","sp|Q9NUM4|T106B_HUMAN;tr|C9JZ87|C9JZ87_HUMAN",4733,"Q9NUM4","T106B_HUMAN","Transmembrane protein 106B",null,"TMEM106B"]
["17.9178",1,"21.0097",1,1,"19.7013",{"$nulls":4},"RNA binding",{"$nulls":4},5,5,5,"17.5","17.5","17.5","32.915",0,"7.7466",108740000,7,"0.277232",1,"6.07539","0.68996","tr|H0YCB3|H0YCB3_HUMAN;sp|Q8N9N2|ASCC1_HUMAN;tr|H0YER2|H0YER2_HUMAN;tr|H0YE76|H0YE76_HUMAN;tr|E9PM82|E9PM82_HUMAN;tr|E9PKM6|E9PKM6_HUMAN;tr|E9PR40|E9PR40_HUMAN;tr|E9PQZ6|E9PQZ6_HUMAN","tr|H0YCB3|H0YCB3_HUMAN;sp|Q8N9N2|ASCC1_HUMAN;tr|H0YER2|H0YER2_HUMAN;tr|H0YE76|H0YE76_HUMAN",3439,"H0YCB3","H0YCB3_HUMAN",null,null,"ASCC1"]
["18.9976",1,"19.1119",1,1,"18.9186",{"$nulls":3},"tetrahydrobiopterin biosynthetic process","6-pyruvoyltetrahydropterin synthase activity",{"$nulls":4},1,1,1,"15.6","15.6","15.6","8.9132","0.0057174","2.3871",11622000,0,"0.288994",1,"6.06366","0.715128","tr|E9PNN3|E9PNN3_HUMAN;sp|Q03393|PTPS_HUMAN","tr|E9PNN3|E9PNN3_HUMAN;sp|Q03393|PTPS_HUMAN",2176,"E9PNN3","E9PNN3_HUMAN",null,null,"PTS"]
["19.3975","18.0872",18,1,"17.9604","18.3414",{"$nulls":3},"translation","methyltransferase activity","mitochondrion;ribosome",{"$nulls":3},10,10,10,"23.9","23.9","23.9","50.733",0,"48.34",452510000,43,"0.455622",1,"6.06098","1.05668","sp|Q9H7H0|MET17_HUMAN;tr|G3V353|G3V353_HUMAN;tr|G3V4P2|G3V4P2_HUMAN;tr|G3V3X6|G3V3X6_HUMAN;tr|H0YJW1|H0YJW1_HUMAN;tr|G3V4H5|G3V4H5_HUMAN;tr|B4E298|B4E298_HUMAN","sp|Q9H7H0|MET17_HUMAN",4507,"Q9H7H0","MET17_HUMAN","Methyltransferase-like protein 17, mitochondrial",null,"METTL17"]
["15.2448","14.6744",1,1,"10.8613",1,{"$nulls":3},"histone methylation;regulation of transcription, DNA-templated;transcription, DNA-templated","histone-lysine N-methyltransferase activity;metal ion binding","chromosome;nucleoplasm;nucleus","Lysine degradation",null,null,15,15,15,"13.4","13.4","13.4","161.61",0,"55.516",258060000,44,"0.455333",1,"6.0193","1.05611","sp|Q9BZ95|NSD3_HUMAN;tr|E9PKA2|E9PKA2_HUMAN;tr|H0YE68|H0YE68_HUMAN","sp|Q9BZ95|NSD3_HUMAN",4325,"Q9BZ95","NSD3_HUMAN","Histone-lysine N-methyltransferase NSD3",null,"NSD3"]
[1,"17.7524","17.9973",1,"16.7138",1,{"$nulls":4},"exo-alpha-sialidase activity","integral component of membrane",{"$nulls":3},1,1,1,"5.2","5.2","5.2",29,"0.0080571","2.2852",12929000,1,"0.320723",1,"6.01198","0.782154","tr|E9PIF4|E9PIF4_HUMAN;sp|Q99519|NEUR1_HUMAN","tr|E9PIF4|E9PIF4_HUMAN;sp|Q99519|NEUR1_HUMAN",4070,"E9PIF4","E9PIF4_HUMAN",null,null,"NEU1"]
[1,"16.4165","18.2285",1,"15.6141",1,{"$nulls":3},"negative regulation of cell differentiation;negative regulation of cell migration;positive regulation of cell proliferation",null,"Sin3 complex",{"$nulls":3},3,3,3,"20.8","20.8","20.8","24.852",0,"7.664",41740000,4,"0.339314",1,"6.01031","0.820896","sp|Q9NP50|FA60A_HUMAN","sp|Q9NP50|FA60A_HUMAN",4619,"Q9NP50","SHCAF_HUMAN","SIN3-HDAC complex-associated factor {ECO:0000312|HGNC:HGNC:30702}",null,"SINHCAF"]
["18.3233","17.974",1,1,"17.2686",1,{"$nulls":3},"apoptotic process;cell cycle arrest;cell growth;cellular protein localization;cellular response to amino acid starvation;cellular response to amino acid stimulus;positive regulation of TOR signaling;regulation of autophagy;regulation of macroautophagy;regulation of TOR signaling;regulation of TORC1 signaling;response to amino acid;RNA splicing;small GTPase mediated signal transduction;transcription, DNA-templated","GDP binding;GTP binding;GTPase activity;GTPase binding;magnesium ion binding;protein heterodimerization activity","cytoplasm;cytosol;EGO complex;Gtr1-Gtr2 GTPase complex;intracellular membrane-bounded organelle;lysosome;nucleus","Autophagy - animal;mTOR signaling pathway",null,null,3,3,3,"8.5","8.5","8.5","44.223","0.0010126","3.7441",37481000,2,"0.31143",1,"6.00957","0.762647","sp|Q9HB90|RRAGC_HUMAN;sp|Q9NQL2|RRAGD_HUMAN","sp|Q9HB90|RRAGC_HUMAN;sp|Q9NQL2|RRAGD_HUMAN",4571,"Q9HB90","RRAGC_HUMAN","Ras-related GTP-binding protein C","ag C;agC","RRAGC"]
["19.3537","17.1648","17.5727","18.6219","16.4507",1,{"$nulls":3},"cell redox homeostasis;oxidation-reduction process;protein folding;response to endoplasmic reticulum stress","protein disulfide isomerase activity","endoplasmic reticulum;integral component of membrane",{"$nulls":3},3,3,3,"10.3","10.3","10.3","38.952",0,"8.0362",28257000,3,"0.464741",1,"6.00621","1.07481","sp|Q9H1E5|TMX4_HUMAN","sp|Q9H1E5|TMX4_HUMAN",4414,"Q9H1E5","TMX4_HUMAN","Thioredoxin-related transmembrane protein 4",null,"TMX4"]
["20.0603","16.0586",1,1,1,"17.1295",{"$nulls":9},5,5,5,"26.4","26.4","26.4","39.97",0,"17.391",93485000,15,"0.309238",1,"5.99645","0.75803","tr|F6WFU6|F6WFU6_HUMAN;sp|Q9NZJ7|MTCH1_HUMAN;tr|H0Y8C3|H0Y8C3_HUMAN","tr|F6WFU6|F6WFU6_HUMAN;sp|Q9NZJ7|MTCH1_HUMAN;tr|H0Y8C3|H0Y8C3_HUMAN",4877,"F6WFU6"]
["19.0064","18.6797","16.0599","17.2217","17.562",1,{"$nulls":3},"mRNA splicing, via spliceosome","peptidyl-prolyl cis-trans isomerase activity","catalytic step 2 spliceosome;nuclear body;nucleoplasm",{"$nulls":3},6,6,6,"12.2","12.2","12.2","73.574",0,"17.311",96943000,15,"0.467367",1,"5.98743","1.08002","sp|Q96BP3|PPWD1_HUMAN;tr|F5H7P7|F5H7P7_HUMAN;tr|D6RB19|D6RB19_HUMAN;tr|D6RHV0|D6RHV0_HUMAN;tr|D6RA12|D6RA12_HUMAN;tr|D6RDA4|D6RDA4_HUMAN;tr|H0Y8N5|H0Y8N5_HUMAN","sp|Q96BP3|PPWD1_HUMAN;tr|F5H7P7|F5H7P7_HUMAN;tr|D6RB19|D6RB19_HUMAN;tr|D6RHV0|D6RHV0_HUMAN",3810,"Q96BP3","PPWD1_HUMAN","Peptidylprolyl isomerase domain and WD repeat-containing protein 1",null,"PPWD1"]
["18.4523",1,"20.0051",1,1,"19.522",{"$nulls":9},4,4,4,"33.1","33.1","33.1","16.324",0,"7.5298",50114000,6,"0.276893",1,"5.97847","0.689232","tr|H3BSW0|H3BSW0_HUMAN;sp|Q8N9N7|LRC57_HUMAN","tr|H3BSW0|H3BSW0_HUMAN;sp|Q8N9N7|LRC57_HUMAN",3440,"H3BSW0","H3BSW0_HUMAN",null,null,"LRRC57"]
["19.3252","18.8045","18.7843","19.222",1,"18.7711",{"$nulls":3},"negative regulation of defense response to virus;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interferon-beta production;negative regulation of NF-kappaB import into nucleus;N-terminal protein myristoylation;peptidyl-threonine dephosphorylation;protein dephosphorylation","magnesium ion binding;manganese ion binding;protein serine/threonine phosphatase activity","cytosol;membrane;nucleolus","MAPK signaling pathway",null,null,6,6,4,"16.1","16.1","11.5","52.642",0,"15.354",103870000,15,"0.424815",1,"5.97364","0.995128","sp|O75688|PPM1B_HUMAN;tr|B8ZZF0|B8ZZF0_HUMAN;tr|C9JIR6|C9JIR6_HUMAN","sp|O75688|PPM1B_HUMAN;tr|B8ZZF0|B8ZZF0_HUMAN;tr|C9JIR6|C9JIR6_HUMAN",623,"O75688","PPM1B_HUMAN","Protein phosphatase 1B",null,"PPM1B"]
["18.3566","17.8399",1,1,"17.3032",1,{"$nulls":3},"covalent chromatin modification;gamete generation;meiotic cell cycle;multicellular organism development;positive regulation of transcription, DNA-templated;positive regulation of Wnt signaling pathway;rRNA transcription;Wnt signaling pathway","methylated histone binding","cytosol;nuclear membrane;nucleolus;nucleoplasm;nucleus;spindle",{"$nulls":3},4,4,4,"24.8","24.8","24.8","29.6",0,"6.7426",42279000,5,"0.308867",1,"5.96442","0.757248","sp|Q9Y657|SPIN1_HUMAN;sp|Q5JUX0|SPIN3_HUMAN","sp|Q9Y657|SPIN1_HUMAN",5388,"Q9Y657","SPIN1_HUMAN","Spindlin-1",null,"SPIN1"]
["18.3878",1,"19.2269",1,1,"18.7398",{"$nulls":9},5,5,5,"16.8","16.8","16.8","53.567",0,"7.5167",35911000,5,"0.286984",1,"5.95831","0.71084","tr|E7ENA2|E7ENA2_HUMAN;tr|D3YTF8|D3YTF8_HUMAN;tr|D3YTF9|D3YTF9_HUMAN;sp|Q9NNW7|TRXR2_HUMAN;tr|A0A096LNN4|A0A096LNN4_HUMAN;tr|A0A096LPK7|A0A096LPK7_HUMAN;tr|A0A096LPH4|A0A096LPH4_HUMAN;tr|A0A096LP96|A0A096LP96_HUMAN;tr|A0A096LPB7|A0A096LPB7_HUMAN;tr|A0A096LPD9|A0A096LPD9_HUMAN;tr|E7EWK1|E7EWK1_HUMAN","tr|E7ENA2|E7ENA2_HUMAN;tr|D3YTF8|D3YTF8_HUMAN;tr|D3YTF9|D3YTF9_HUMAN;sp|Q9NNW7|TRXR2_HUMAN;tr|A0A096LNN4|A0A096LNN4_HUMAN;tr|A0A096LPK7|A0A096LPK7_HUMAN",4617,"E7ENA2"]
["19.6298",1,"19.1218",1,1,"19.8809",{"$nulls":3},"gluconeogenesis;glucose homeostasis;histone H3-K9 acetylation;positive regulation of CREB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;protein homotetramerization;toxin transport;transcription, DNA-templated;viral process","cAMP response element binding protein binding;chromatin binding","cytoplasm;extracellular exosome;nucleoplasm;nucleus","AMPK signaling pathway;Glucagon signaling pathway;Human T-cell leukemia virus 1 infection;Insulin resistance;PI3K-Akt signaling pathway",null,null,1,1,1,"1.7","1.7","1.7","73.301","0.0026646","2.8766",44878000,2,"0.271762",1,"5.95688","0.678189","sp|Q53ET0|CRTC2_HUMAN","sp|Q53ET0|CRTC2_HUMAN",2770,"Q53ET0","CRTC2_HUMAN","CREB-regulated transcription coactivator 2",null,"CRTC2"]
["21.1052",1,"17.801","20.049",1,1,{"$nulls":3},"cellular iron ion homeostasis;Fc-epsilon receptor signaling pathway;G2/M transition of mitotic cell cycle;histone H2A monoubiquitination;maintenance of protein location in nucleus;negative regulation of G2/M transition of mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein polyubiquitination;protein ubiquitination;SCF complex assembly;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;Wnt signaling pathway","beta-catenin binding;cullin family protein binding;protein domain specific binding;ubiquitin-protein transferase activity","Cul7-RING ubiquitin ligase complex;cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;SCF ubiquitin ligase complex","Cell cycle;Circadian rhythm;Human immunodeficiency virus 1 infection;Oocyte meiosis;Pathways in cancer;Protein processing in endoplasmic reticulum;TGF-beta signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway",null,null,4,4,4,"28.2","28.2","28.2","18.658",0,"26.041",47938000,5,"0.267704",1,"5.95241","0.66943","sp|P63208|SKP1_HUMAN;tr|E5RJR5|E5RJR5_HUMAN;tr|E7ERH2|E7ERH2_HUMAN;tr|F8W8N3|F8W8N3_HUMAN;tr|E5RGM3|E5RGM3_HUMAN","sp|P63208|SKP1_HUMAN;tr|E5RJR5|E5RJR5_HUMAN;tr|E7ERH2|E7ERH2_HUMAN;tr|F8W8N3|F8W8N3_HUMAN",2028,"P63208","SKP1_HUMAN","S-phase kinase-associated protein 1",null,"SKP1"]
["18.1692",1,"18.6328",1,1,"17.9514",{"$nulls":3},"nervous system development",null,"integral component of membrane;mitochondrion",{"$nulls":3},1,1,1,5,5,5,"22.049","0.00081599","3.8971",30870000,3,"0.298202",1,"5.95018","0.734705","sp|A0PJW6|TM223_HUMAN","sp|A0PJW6|TM223_HUMAN",168,"A0PJW6","TM223_HUMAN","Transmembrane protein 223",null,"TMEM223"]
["18.5811","17.2071",1,1,"16.9423",1,{"$nulls":3},"positive regulation of gene expression, epigenetic;regulation of transcription, DNA-templated;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription from RNA polymerase I promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter","DNA binding","intracellular membrane-bounded organelle;microtubule cytoskeleton;nucleoplasm;nucleus;RNA polymerase I transcription factor complex",{"$nulls":3},2,2,2,"4.9","4.9","4.9","52.675","0.0057227","2.3938",49878000,1,"0.313629",1,"5.94867","0.767271","sp|Q15573|TAF1A_HUMAN;tr|Q5JRA7|Q5JRA7_HUMAN","sp|Q15573|TAF1A_HUMAN;tr|Q5JRA7|Q5JRA7_HUMAN",2616,"Q15573","TAF1A_HUMAN","TATA box-binding protein-associated factor RNA polymerase I subunit A",null,"TAF1A"]
["18.867",1,"17.8006",1,1,"17.8381",{"$nulls":3},"neutrophil degranulation","nucleic acid binding;transferase activity;zinc ion binding","extracellular region;ficolin-1-rich granule lumen",{"$nulls":3},2,2,2,"11.5","11.5","11.5","41.945",0,"10.604",20739000,5,"0.299411",1,"5.94321","0.737268","sp|Q9P0J7|KCMF1_HUMAN","sp|Q9P0J7|KCMF1_HUMAN",4905,"Q9P0J7","KCMF1_HUMAN","E3 ubiquitin-protein ligase KCMF1",null,"KCMF1"]
["18.3014","17.9119","15.6004",1,"17.9302","15.072",{"$nulls":3},"transcription initiation from RNA polymerase II promoter","RNA polymerase II transcription cofactor activity","cytoplasm;mediator complex;membrane;nucleoplasm;nucleus",{"$nulls":3},7,7,7,"13.1","13.1","13.1","86.753",0,"33.11",103380000,17,"0.487676",1,"5.93718","1.12023","sp|Q96RN5|MED15_HUMAN;tr|G3V1P5|G3V1P5_HUMAN;tr|F8WDM6|F8WDM6_HUMAN;tr|F2Z2B7|F2Z2B7_HUMAN;tr|H7C308|H7C308_HUMAN","sp|Q96RN5|MED15_HUMAN;tr|G3V1P5|G3V1P5_HUMAN",4019,"Q96RN5","MED15_HUMAN","Mediator of RNA polymerase II transcription subunit 15",null,"MED15"]
["18.653",1,"18.2595",1,1,"18.1055",{"$nulls":3},"box C/D snoRNA 3'-end processing;histone glutamine methylation;rRNA methylation;tRNA processing","histone-glutamine methyltransferase activity;RNA binding;rRNA methyltransferase activity","box C/D snoRNP complex;Cajal body;fibrillar center;nucleus;small-subunit processome",{"$nulls":3},5,2,2,15,"3.6","3.6","34.803","0.00021598","5.1082",96940000,8,"0.295289",1,"5.93566","0.728525","sp|A6NHQ2|FBLL1_HUMAN","sp|A6NHQ2|FBLL1_HUMAN",185,"A6NHQ2","FBLL1_HUMAN","rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1",null,"FBLL1"]
["19.3051","16.7396",1,1,"17.2431",1,{"$nulls":3},"apoptotic process;FMN biosynthetic process;positive regulation of NAD(P)H oxidase activity;reactive oxygen species metabolic process;riboflavin biosynthetic process;riboflavin metabolic process","ATP binding;metal ion binding;riboflavin kinase activity","cytoplasm;cytosol;mitochondrion","Metabolic pathways;Riboflavin metabolism",null,null,2,2,2,"20.6","20.6","20.6","17.623",0,"5.7805",8150700,2,"0.306966",1,"5.93387","0.753241","sp|Q969G6|RIFK_HUMAN;tr|H7C4G0|H7C4G0_HUMAN","sp|Q969G6|RIFK_HUMAN;tr|H7C4G0|H7C4G0_HUMAN",3759,"Q969G6","RIFK_HUMAN","Riboflavin kinase",null,"RFK"]
["18.8739","18.0703","18.8225",1,"18.2833","18.7121",{"$nulls":4},"protein homodimerization activity","endosome;extracellular exosome;integral component of membrane;late endosome;lysosomal membrane;lysosome;nucleoplasm;perinuclear region of cytoplasm",{"$nulls":3},2,2,2,"9.6","9.6","9.6","30.922","0.0004128","4.1447",52331000,10,"0.434431",1,"5.92375","1.0144","sp|Q8IY95|TM192_HUMAN","sp|Q8IY95|TM192_HUMAN",3335,"Q8IY95","TM192_HUMAN","Transmembrane protein 192",null,"TMEM192"]
["19.1533","15.2769","18.8117",1,"15.2406","19.2743",{"$nulls":4},"RNA binding",{"$nulls":4},7,1,1,"63.6","12.1","12.1","15.46",0,"14.082",19796000,3,"0.447436",1,"5.90899","1.04038","tr|J3KTC1|J3KTC1_HUMAN","tr|J3KTC1|J3KTC1_HUMAN",5588,"J3KTC1","J3KTC1_HUMAN",null,null,"MSI2"]
["20.4641","17.7704","18.0817","20.0091","17.6243",1,{"$nulls":3},"intraciliary transport involved in cilium assembly;microtubule-based movement;visual behavior","dynein intermediate chain binding;microtubule motor activity","centrosome;ciliary tip;cilium;cytoplasm;cytoplasmic dynein complex;membrane;microtubule;outer dynein arm",{"$nulls":3},2,2,2,"29.2","29.2","29.2","10.921",0,"5.9463",22631000,3,"0.415325",1,"5.8943","0.976057","sp|Q9NP97|DLRB1_HUMAN;tr|B1AKR6|B1AKR6_HUMAN;sp|Q8TF09|DLRB2_HUMAN;tr|H3BQI1|H3BQI1_HUMAN","sp|Q9NP97|DLRB1_HUMAN;tr|B1AKR6|B1AKR6_HUMAN;sp|Q8TF09|DLRB2_HUMAN;tr|H3BQI1|H3BQI1_HUMAN",4628,"Q9NP97","DLRB1_HUMAN","Dynein light chain roadblock-type 1",null,"DYNLRB1"]
["18.2017",1,"18.2885",1,1,"17.8093",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding","intracellular membrane-bounded organelle;nucleolus;nucleus","Spliceosome",null,null,1,1,1,5,5,5,"32.688","0.0011837","3.3676",22913000,2,"0.297959",1,"5.89364","0.734191","sp|Q13595|TRA2A_HUMAN","sp|Q13595|TRA2A_HUMAN",2387,"Q13595","TRA2A_HUMAN","Transformer-2 protein homolog alpha","RA-2 alpha;RA2-alpha","TRA2A"]
["18.8976","16.3817",1,1,"16.6298",1,{"$nulls":3},"cell cycle;negative regulation of fat cell proliferation;positive regulation of cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of vascular associated smooth muscle cell apoptotic process;transcription initiation from RNA polymerase II promoter","core promoter binding;DNA binding transcription factor activity;protein dimerization activity;sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytosol;nucleoplasm;RNA polymerase II transcription factor complex","Bladder cancer;Breast cancer;Cell cycle;Cellular senescence;Chronic myeloid leukemia;Cushing syndrome;Endocrine resistance;Epstein-Barr virus infection;Gastric cancer;Glioma;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Human cytomegalovirus infection;Human T-cell leukemia virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Melanoma;MicroRNAs in cancer;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Prostate cancer;Small cell lung cancer",null,null,2,2,2,"4.3","4.3","4.3","49.161","0.00041425","4.1875",38379000,5,"0.314744",1,"5.88316","0.769614","sp|O00716|E2F3_HUMAN","sp|O00716|E2F3_HUMAN",262,"O00716","E2F3_HUMAN","Transcription factor E2F3","2F-3","E2F3"]
["18.1301","14.905","17.0852","15.3379",1,"16.1469",{"$nulls":3},"calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;multicellular organism development",null,"cytoplasm;nucleus;plasma membrane",{"$nulls":3},4,4,4,"7.4","7.4","7.4","96.827",0,"8.4344",42808000,9,"0.514559",1,"5.8785","1.17322","tr|C9JJX6|C9JJX6_HUMAN;tr|E9PDC3|E9PDC3_HUMAN;sp|O00192|ARVC_HUMAN","tr|C9JJX6|C9JJX6_HUMAN;tr|E9PDC3|E9PDC3_HUMAN;sp|O00192|ARVC_HUMAN",210,"C9JJX6","C9JJX6_HUMAN",null,null,"ARVCF"]
["20.0359","15.7176","17.3233","19.5304","14.9186",1,{"$nulls":3},"3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;blood coagulation;bone development;skeletal system development;sulfate assimilation","adenylylsulfate kinase activity;ATP binding;nucleotidyltransferase activity;sulfate adenylyltransferase (ATP) activity","cytosol","Metabolic pathways;Purine metabolism;Selenocompound metabolism;Sulfur metabolism",null,null,10,9,9,"18.9","16.6","16.6","69.5",0,"20.201",140930000,9,"0.441734",1,"5.87598","1.029","sp|O95340|PAPS2_HUMAN","sp|O95340|PAPS2_HUMAN",742,"O95340","PAPS2_HUMAN","Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2","APS synthase 2;APSS 2","PAPSS2"]
["19.1045","18.667",1,"19.1578",1,1,{"$nulls":3},"miRNA loading onto RISC involved in gene silencing by miRNA;pre-miRNA processing;production of siRNA involved in RNA interference;regulation of viral transcription","double-stranded RNA binding;siRNA binding","RISC complex",{"$nulls":3},2,2,2,"30.7","30.7","30.7","9.3606","0.00042427","4.7045",10954000,1,"0.277715",1,"5.87121","0.690997","tr|F8VYK6|F8VYK6_HUMAN;tr|F8VZZ7|F8VZZ7_HUMAN;tr|F8VP94|F8VP94_HUMAN;tr|F8VYK3|F8VYK3_HUMAN;sp|Q15633|TRBP2_HUMAN;tr|F8VTT7|F8VTT7_HUMAN;tr|F8VZ57|F8VZ57_HUMAN","tr|F8VYK6|F8VYK6_HUMAN;tr|F8VZZ7|F8VZZ7_HUMAN;tr|F8VP94|F8VP94_HUMAN;tr|F8VYK3|F8VYK3_HUMAN;sp|Q15633|TRBP2_HUMAN;tr|F8VTT7|F8VTT7_HUMAN;tr|F8VZ57|F8VZ57_HUMAN",2622,"F8VYK6","F8VYK6_HUMAN",null,null,"TARBP2"]
["16.7244","16.1296",1,1,"14.2416",1,{"$nulls":3},"ameboidal-type cell migration;cell cycle;cell division;centromere complex assembly;metabolic process;pericentric heterochromatin assembly;positive regulation of cytokinesis;regulation of chromosome organization","carbon-sulfur lyase activity","condensed chromosome kinetochore;cytosol;kinetochore;microtubule cytoskeleton;nucleoplasm;nucleus;spindle midzone",{"$nulls":3},2,2,2,"13.5","13.5","13.5","29.946","0.0028436","2.7902",30842000,5,"0.361179",1,"5.8708","0.866023","sp|Q7Z7K6|CENPV_HUMAN;tr|A0A0M3HER2|A0A0M3HER2_HUMAN","sp|Q7Z7K6|CENPV_HUMAN;tr|A0A0M3HER2|A0A0M3HER2_HUMAN",3199,"Q7Z7K6","CENPV_HUMAN","Centromere protein V","ENP-V","CENPV"]
["17.6487","14.2604","16.9753",1,"14.1853","16.1074",{"$nulls":3},"selenocysteine incorporation","RNA binding","cytoplasm;nucleus",{"$nulls":3},1,1,1,7,7,7,"32.498","0.001182","3.3354",5616800,1,"0.531593",1,"5.86394","1.20667","sp|Q9NX07|TSAP1_HUMAN","sp|Q9NX07|TSAP1_HUMAN",4806,"Q9NX07","TSAP1_HUMAN","tRNA selenocysteine 1-associated protein 1",null,"TRNAU1AP"]
["17.7982","16.6001",1,1,"15.8384",1,{"$nulls":4},"metal ion binding","nucleolus",{"$nulls":3},1,1,1,"4.6","4.6","4.6","45.341","0.00042212","4.6091",19636000,3,"0.328524",1,"5.85331","0.798454","tr|J3QT87|J3QT87_HUMAN;sp|Q96SW2|CRBN_HUMAN","tr|J3QT87|J3QT87_HUMAN;sp|Q96SW2|CRBN_HUMAN",4044,"J3QT87","J3QT87_HUMAN",null,null,"CRBN"]
["17.8598","17.2455","17.081",1,"16.6254","17.02",{"$nulls":3},"retrograde transport, endosome to Golgi",null,"cytosol;Golgi membrane;integral component of membrane",{"$nulls":3},1,1,1,"2.2","2.2","2.2","63.535","0.00081185","3.8115",32860000,6,"0.481093",1,"5.84698","1.10722","sp|Q96K49|TM87B_HUMAN","sp|Q96K49|TM87B_HUMAN",3953,"Q96K49","TM87B_HUMAN","Transmembrane protein 87B {ECO:0000305}",null,"TMEM87B"]
["18.4217",1,"17.5419",1,1,"17.497",{"$nulls":3},"DNA repair;global genome nucleotide-excision repair;histone H2A monoubiquitination;nucleotide-excision repair;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;post-translational protein modification;protein autoubiquitination;protein deubiquitination;protein polyubiquitination;pyrimidine dimer repair;response to UV;UV-damage excision repair","damaged DNA binding;DNA binding;protein complex binding","cell junction;Cul4B-RING E3 ubiquitin ligase complex;Cul4-RING E3 ubiquitin ligase complex;nucleoplasm;protein complex","Basal cell carcinoma;Breast cancer;Chronic myeloid leukemia;Colorectal cancer;Endometrial cancer;Epstein-Barr virus infection;Gastric cancer;Glioma;Hepatitis B;Hepatocellular carcinoma;Melanoma;Non-small cell lung cancer;Nucleotide excision repair;p53 signaling pathway;Pancreatic cancer;Pathways in cancer;Small cell lung cancer;Thyroid cancer;Transcriptional misregulation in cancer;Ubiquitin mediated proteolysis",null,null,5,5,5,"16.9","16.9","16.9","47.863",0,"41.042",22735000,6,"0.299457",1,"5.82219","0.737365","sp|Q92466|DDB2_HUMAN;tr|A0A087X0X5|A0A087X0X5_HUMAN;tr|A0A087WYT8|A0A087WYT8_HUMAN;tr|A0A087WW71|A0A087WW71_HUMAN","sp|Q92466|DDB2_HUMAN;tr|A0A087X0X5|A0A087X0X5_HUMAN",3662,"Q92466","DDB2_HUMAN","DNA damage-binding protein 2",null,"DDB2"]
["17.915","16.891","17.923",1,"16.9886","17.2802",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated",null,"nuclear speck;Sin3-type complex",{"$nulls":3},4,4,4,"4.2","4.2","4.2","110.32",0,"14.142",112470000,13,"0.46728",1,"5.82006","1.07985","sp|Q9H0E3|SP130_HUMAN;tr|H7BXF5|H7BXF5_HUMAN;tr|C9J683|C9J683_HUMAN","sp|Q9H0E3|SP130_HUMAN;tr|H7BXF5|H7BXF5_HUMAN",4388,"Q9H0E3","SP130_HUMAN","Histone deacetylase complex subunit SAP130",null,"SAP130"]
["18.1495","15.174",1,1,"14.877",1,{"$nulls":3},"apoptotic process;multicellular organismal lipid catabolic process;negative regulation of peptidyl-lysine acetylation;steroid biosynthetic process","hydrolase activity;nucleotide binding","mitochondrion;nucleolus",{"$nulls":3},1,1,1,"12.3","12.3","12.3","17.162","0.0071652","2.3218",4345000,1,"0.342504",1,"5.81552","0.827509","sp|Q9BX68|HINT2_HUMAN","sp|Q9BX68|HINT2_HUMAN",4287,"Q9BX68","HINT2_HUMAN","Histidine triad nucleotide-binding protein 2, mitochondrial","INT-2","HINT2"]
["18.6083",1,"17.195",1,1,"17.3621",{"$nulls":9},2,2,2,"16.6","16.6","16.6","17.574",0,"6.1489",21850000,1,"0.300897",1,"5.81373","0.740415","tr|B9A054|B9A054_HUMAN;sp|Q8TEB9|RHBL4_HUMAN","tr|B9A054|B9A054_HUMAN;sp|Q8TEB9|RHBL4_HUMAN",3575,"B9A054","B9A054_HUMAN",null,null,"RHBDD1"]
["17.3202","15.618","17.7677",1,"15.4715","16.7934",{"$nulls":3},"neuron differentiation","RNA binding","extracellular region;nucleus",{"$nulls":3},1,1,1,"6.9","6.9","6.9","32.407","0.0011902","3.4538",12480000,2,"0.497572",1,"5.81368","1.13977","sp|Q9NPE2|NGRN_HUMAN","sp|Q9NPE2|NGRN_HUMAN",4634,"Q9NPE2","NGRN_HUMAN","Neugrin",null,"NGRN"]
["18.3016","17.561",1,1,"17.437",1,{"$nulls":9},4,4,4,"20.1","20.1","20.1","24.605",0,"7.9999",45503000,5,"0.299841",1,"5.80855","0.73818","tr|Q5VXN0|Q5VXN0_HUMAN;sp|Q9H7B2|RPF2_HUMAN","tr|Q5VXN0|Q5VXN0_HUMAN;sp|Q9H7B2|RPF2_HUMAN",4502,"Q5VXN0","Q5VXN0_HUMAN",null,null,"RPF2"]
["18.2024","20.4867",1,1,"20.2704",1,{"$nulls":3},"metabolic process","hydrolase activity","mitochondrion",{"$nulls":3},3,3,3,"19.1","19.1","19.1",28,"0.00042599","4.7961",74172000,3,"0.260073",1,"5.80624","0.652893","sp|Q9BSH5|HDHD3_HUMAN","sp|Q9BSH5|HDHD3_HUMAN",4184,"Q9BSH5","HDHD3_HUMAN","Haloacid dehalogenase-like hydrolase domain-containing protein 3",null,"HDHD3"]
["18.8033",1,"17.7623",1,1,"18.1507",{"$nulls":3},"positive regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter;RNA polymerase II transcriptional preinitiation complex assembly;transcription initiation from RNA polymerase II promoter","RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly;transcription coactivator activity;transcription factor binding","core mediator complex;mediator complex;membrane;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"13.8","13.8","13.8","28.424",0,"7.9204",117050000,12,"0.288816",1,"5.80496","0.714749","sp|O75586|MED6_HUMAN;tr|G3V4A5|G3V4A5_HUMAN;tr|A0A087WYL7|A0A087WYL7_HUMAN","sp|O75586|MED6_HUMAN;tr|G3V4A5|G3V4A5_HUMAN;tr|A0A087WYL7|A0A087WYL7_HUMAN",610,"O75586","MED6_HUMAN","Mediator of RNA polymerase II transcription subunit 6",null,"MED6"]
["17.8885","15.3346",1,1,"14.81",1,{"$nulls":3},"intracellular protein transport","Ran GTPase binding","intracellular",{"$nulls":3},8,1,1,"60.4","13.2","13.2","20.487","0.00041938","4.4433",3989200,1,"0.344079",1,"5.80435","0.830769","tr|H0Y3V4|H0Y3V4_HUMAN","tr|H0Y3V4|H0Y3V4_HUMAN",5558,"H0Y3V4","H0Y3V4_HUMAN",null,null,"IPO5"]
["18.2901",1,"17.1761",1,1,"17.0545",{"$nulls":3},"actin filament organization;cell migration;dendritic spine development;ephrin receptor signaling pathway;epidermal growth factor receptor signaling pathway;immunological synapse formation;lamellipodium assembly;negative regulation of cell proliferation;negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;negative regulation of peptidyl-serine phosphorylation;negative regulation of PERK-mediated unfolded protein response;negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;positive regulation of actin filament polymerization;positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;positive regulation of T cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of translation in response to endoplasmic reticulum stress;regulation of epidermal growth factor-activated receptor activity;signal complex assembly;signal transduction;T cell activation;vascular endothelial growth factor receptor signaling pathway","cytoskeletal adaptor activity;phosphotyrosine residue binding;protein complex binding;receptor signaling complex scaffold activity;scaffold protein binding;SH3/SH2 adaptor activity","cytoplasm;cytosol;endoplasmic reticulum;postsynaptic density;vesicle membrane","Axon guidance;ErbB signaling pathway;Pathogenic Escherichia coli infection;T cell receptor signaling pathway",null,null,4,3,3,"18.9","16.8","16.8","42.915",0,"5.9047",15795000,3,"0.305525",1,"5.80388","0.750199","sp|O43639|NCK2_HUMAN","sp|O43639|NCK2_HUMAN",436,"O43639","NCK2_HUMAN","Cytoplasmic protein NCK2",null,"NCK2"]
["20.8794","18.3258",1,"20.8192",1,1,{"$nulls":3},"histone H3 acetylation;negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","DNA binding;protein heterodimerization activity;TBP-class protein binding;transcription corepressor activity;transcription factor binding","Ada2/Gcn5/Ada3 transcription activator complex;nucleus",{"$nulls":3},3,3,3,29,29,29,"19.443",0,"21.482",45038000,2,"0.253012",1,"5.79536","0.637513","sp|Q01658|NC2B_HUMAN","sp|Q01658|NC2B_HUMAN",2143,"Q01658","NC2B_HUMAN","Protein Dr1",null,"DR1"]
["18.613","17.2827","18.119","18.7135","17.032",1,{"$nulls":3},"tRNA (guanine-N7)-methylation;tRNA modification",null,"cytosol;nucleoplasm;nucleus;tRNA methyltransferase complex",{"$nulls":3},1,1,1,"2.7","2.7","2.7","45.489","0.0048498","2.5432",37119000,3,"0.435885",1,"5.75642","1.01731","sp|P57081|WDR4_HUMAN","sp|P57081|WDR4_HUMAN",1875,"P57081","WDR4_HUMAN","tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 {ECO:0000255|HAMAP-Rule:MF_03056}",null,"WDR4"]
["20.4106","17.9846","18.6131","19.8191","18.9632",1,{"$nulls":9},6,4,4,"58.6","39.8","39.8","14.277",0,"13.683",64860000,8,"0.392227",1,"5.74201","0.929387","tr|E9PLP0|E9PLP0_HUMAN;tr|C9JLN0|C9JLN0_HUMAN","tr|E9PLP0|E9PLP0_HUMAN",5519,"E9PLP0","E9PLP0_HUMAN",null,null,"CARS"]
["18.0612",1,"17.4691",1,1,"17.3707",{"$nulls":3},"protein import into mitochondrial inner membrane",null,"integral component of membrane;mitochondrial inner membrane;mitochondrial inner membrane protein insertion complex;mitochondrial intermembrane space",{"$nulls":3},2,2,2,"14.2","14.2","14.2","29.233","0.00081549","3.8829",24049000,2,"0.29699",1,"5.71988","0.732134","sp|Q9BSF4|CS052_HUMAN","sp|Q9BSF4|CS052_HUMAN",4182,"Q9BSF4","TIM29_HUMAN","Mitochondrial import inner membrane translocase subunit Tim29 {ECO:0000303|PubMed:27554484}","IM29 {ECO:0000303|PubMed:27554484}","TIMM29"]
["17.5599",1,"18.616","18.0186",1,1,{"$nulls":4},"calcium-activated potassium channel activity;potassium channel activity","integral component of membrane;nuclear membrane;nucleus;sarcoplasmic reticulum membrane",{"$nulls":3},2,2,2,"8.2","8.2","8.2","32.509","0.00041745","4.3453",18380000,2,"0.287017",1,"5.71912","0.71091","sp|Q9NVV0|TM38B_HUMAN;tr|A0A0A0MRS4|A0A0A0MRS4_HUMAN","sp|Q9NVV0|TM38B_HUMAN;tr|A0A0A0MRS4|A0A0A0MRS4_HUMAN",4777,"Q9NVV0","TM38B_HUMAN","Trimeric intracellular cation channel type B","RICB;RIC-B","TMEM38B"]
["17.8778",1,"18.493",1,1,"18.2412",{"$nulls":3},"peroxisome membrane biogenesis;peroxisome organization;protein import into peroxisome membrane;transmembrane transport","lipid binding;protein dimerization activity","cytosol;endoplasmic reticulum;integral component of peroxisomal membrane;membrane;nucleoplasm;peroxisomal membrane;peroxisome;protein complex;protein-lipid complex","Peroxisome",null,null,1,1,1,"2.7","2.7","2.7","42.139","0.0019268","3.0615",40493000,4,"0.283549",1,"5.70988","0.703501","sp|P56589|PEX3_HUMAN","sp|P56589|PEX3_HUMAN",1870,"P56589","PEX3_HUMAN","Peroxisomal biogenesis factor 3",null,"PEX3"]
["18.5724",1,"19.0941",1,1,"19.605",{"$nulls":9},1,1,1,"42.6","42.6","42.6","7.0578",0,"10.807",5570900,2,"0.264237",1,"5.68717","0.661928","tr|K7ENN3|K7ENN3_HUMAN;tr|K7EN61|K7EN61_HUMAN;tr|K7EIZ9|K7EIZ9_HUMAN;sp|Q92624|APBP2_HUMAN","tr|K7ENN3|K7ENN3_HUMAN;tr|K7EN61|K7EN61_HUMAN;tr|K7EIZ9|K7EIZ9_HUMAN;sp|Q92624|APBP2_HUMAN",3697,"K7ENN3","K7ENN3_HUMAN",null,null,"APPBP2"]
["18.0662","16.9418","17.9174","17.854","17.0206",1,{"$nulls":5},"cytosol;mitochondrion",{"$nulls":3},2,2,2,"8.9","8.9","8.9","31.932","0.00041771","4.3555",19613000,3,"0.444333",1,"5.6836","1.03419","tr|H0YBZ4|H0YBZ4_HUMAN;sp|Q15390|MTFR1_HUMAN","tr|H0YBZ4|H0YBZ4_HUMAN;sp|Q15390|MTFR1_HUMAN",2593,"H0YBZ4","H0YBZ4_HUMAN",null,null,"MTFR1"]
["18.1426","17.0002","17.6144",1,"16.8467","17.9126",{"$nulls":3},"post-translational protein modification;protein polyubiquitination;ubiquitin-dependent protein catabolic process","ubiquitin-protein transferase activity","cytosol;ubiquitin ligase complex",{"$nulls":3},1,1,1,"4.9","4.9","4.9","37.026","0.0012012","3.5778",29744000,3,"0.444345",1,"5.66593","1.03421","sp|Q9NXK8|FXL12_HUMAN","sp|Q9NXK8|FXL12_HUMAN",4831,"Q9NXK8","FXL12_HUMAN","F-box/LRR-repeat protein 12",null,"FBXL12"]
["17.8532","17.3052","15.7927",1,"17.4527","15.5022",{"$nulls":3},"muscle cell differentiation;negative regulation of T cell proliferation;neural tube closure;positive regulation of cytokine secretion;positive regulation of interleukin-2 biosynthetic process;positive regulation of phosphorylation;regulation of gene expression, epigenetic;regulation of proteasomal ubiquitin-dependent protein catabolic process;vasculogenesis","hepatocyte growth factor receptor binding;ubiquitin protein ligase binding;ubiquitin-protein transferase inhibitor activity","Cul2-RING ubiquitin ligase complex;Cul3-RING ubiquitin ligase complex;Cul4A-RING E3 ubiquitin ligase complex;cullin-RING ubiquitin ligase complex;cytoplasm;intracellular",{"$nulls":3},5,5,5,"10.9","10.9","10.9","68.207",0,"11.835",43184000,6,"0.46939",1,"5.66541","1.08404","sp|Q92990|GLMN_HUMAN;tr|M0QXG8|M0QXG8_HUMAN;tr|M0QX84|M0QX84_HUMAN","sp|Q92990|GLMN_HUMAN;tr|M0QXG8|M0QXG8_HUMAN",3747,"Q92990","GLMN_HUMAN","Glomulin",null,"GLMN"]
["18.371","17.2426","16.6073","17.6862","16.5585",1,{"$nulls":4},"RNA binding","nuclear body;nucleoplasm",{"$nulls":3},2,2,2,"6.8","6.8","6.8","48.848",0,"24.065",25753000,8,"0.450381",1,"5.65874","1.04625","tr|H7BXE3|H7BXE3_HUMAN;sp|Q9NWH9|SLTM_HUMAN;tr|H0YLW7|H0YLW7_HUMAN;tr|H0YMW8|H0YMW8_HUMAN;tr|H0YNF3|H0YNF3_HUMAN;tr|H0YMR6|H0YMR6_HUMAN;tr|H0YLE6|H0YLE6_HUMAN;tr|H0YL55|H0YL55_HUMAN;tr|H7C3F4|H7C3F4_HUMAN","tr|H7BXE3|H7BXE3_HUMAN;sp|Q9NWH9|SLTM_HUMAN;tr|H0YLW7|H0YLW7_HUMAN;tr|H0YMW8|H0YMW8_HUMAN;tr|H0YNF3|H0YNF3_HUMAN;tr|H0YMR6|H0YMR6_HUMAN;tr|H0YLE6|H0YLE6_HUMAN;tr|H0YL55|H0YL55_HUMAN;tr|H7C3F4|H7C3F4_HUMAN",4789,"H7BXE3","H7BXE3_HUMAN",null,null,"SLTM"]
["17.0951","15.147","16.6424",1,"14.8534","16.1046",{"$nulls":3},"endocytosis;endosome to lysosome transport;endosome transport via multivesicular body sorting pathway;extrinsic apoptotic signaling pathway via death domain receptors;glucose import;Golgi to endosome transport;G-protein coupled receptor signaling pathway;multicellular organism development;myotube differentiation;negative regulation of fat cell differentiation;negative regulation of lipoprotein lipase activity;neuropeptide signaling pathway;neurotrophin TRK receptor signaling pathway;ossification;plasma membrane to endosome transport;positive regulation of epithelial cell apoptotic process;regulation of gene expression;response to insulin;vesicle organization","enzyme binding;nerve growth factor binding;nerve growth factor receptor activity;neurotensin receptor activity, non-G-protein coupled","cell surface;clathrin-coated pit;clathrin-coated vesicle;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;dendrite;early endosome;endoplasmic reticulum membrane;endosome membrane;Golgi apparatus;Golgi cisterna membrane;integral component of membrane;lysosomal membrane;neuronal cell body;nuclear membrane;perinuclear region of cytoplasm;plasma membrane;trans-Golgi network transport vesicle","Cholesterol metabolism;Lysosome;Neurotrophin signaling pathway",null,null,2,2,2,"3.5","3.5","3.5","92.067",0,"7.1194",33541000,5,"0.506444",1,"5.64216","1.15725","sp|Q99523|SORT_HUMAN;tr|A0A0J9YVX1|A0A0J9YVX1_HUMAN;tr|A0A0J9YX61|A0A0J9YX61_HUMAN","sp|Q99523|SORT_HUMAN;tr|A0A0J9YVX1|A0A0J9YVX1_HUMAN;tr|A0A0J9YX61|A0A0J9YX61_HUMAN",4071,"Q99523","SORT_HUMAN","Sortilin",null,"SORT1"]
["17.4183","15.5465","17.1355",1,"15.0279","17.1533",{"$nulls":3},"intracellular protein transport;protein folding","unfolded protein binding","endoplasmic reticulum;endoplasmic reticulum lumen;extracellular space","Protein processing in endoplasmic reticulum",null,null,2,2,2,"5.6","5.6","5.6","52.084","0.00041468","4.2045",16388000,3,"0.480292",1,"5.63968","1.10563","sp|Q9H173|SIL1_HUMAN;tr|D6REA1|D6REA1_HUMAN","sp|Q9H173|SIL1_HUMAN;tr|D6REA1|D6REA1_HUMAN",4408,"Q9H173","SIL1_HUMAN","Nucleotide exchange factor SIL1",null,"SIL1"]
["18.054",1,"17.7414",1,1,"17.9026",{"$nulls":3},"regulation of GTPase activity;signal transduction",{"$nulls":5},7,5,5,"7.2","6.1","6.1","160.33",0,"8.5047",169810000,14,"0.285071",1,"5.63094","0.706755","tr|E7EWC2|E7EWC2_HUMAN;tr|F5H7S7|F5H7S7_HUMAN;sp|Q13576|IQGA2_HUMAN","tr|E7EWC2|E7EWC2_HUMAN;tr|F5H7S7|F5H7S7_HUMAN;sp|Q13576|IQGA2_HUMAN",2385,"E7EWC2","E7EWC2_HUMAN",null,null,"IQGAP2"]
["16.9281","17.6452",1,1,"16.6873",1,{"$nulls":3},"adult locomotory behavior;behavioral fear response;cardiolipin metabolic process;catecholamine secretion;cellular biogenic amine metabolic process;cerebellum development;chromatin silencing;dendrite development;excitatory postsynaptic potential;glucocorticoid metabolic process;glutamine metabolic process;histone acetylation;histone methylation;inositol metabolic process;locomotory behavior;long-term memory;long-term synaptic potentiation;mitochondrial electron transport, ubiquinol to cytochrome c;mitotic spindle organization;negative regulation of histone acetylation;negative regulation of histone methylation;negative regulation of neuron apoptotic process;negative regulation of smooth muscle cell differentiation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation;negative regulation of transcription, DNA-templated;neurological system process involved in regulation of systemic arterial blood pressure;neuron maturation;pathogenesis;phosphatidylcholine metabolic process;positive regulation of cell proliferation;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of histone H3-K9 trimethylation;positive regulation of microtubule nucleation;positive regulation of synapse assembly;positive regulation of transcription, DNA-templated;post-embryonic development;proprioception;protein localization;regulation of gene expression by genetic imprinting;regulation of respiratory gaseous exchange by neurological system process;respiratory gaseous exchange;response to hypoxia;response to radiation;sensory perception of pain;social behavior;startle response;synapse assembly;transcription, DNA-templated;ventricular system development;visual learning","chromatin binding;DNA binding;double-stranded methylated DNA binding;methyl-CpG binding;mRNA binding;protein domain specific binding;protein N-terminus binding;RNA binding;siRNA binding;transcription corepressor activity;transcription factor binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytosol;extracellular space;heterochromatin;mitochondrion;nucleus;postsynapse",{"$nulls":3},7,7,4,"20.2","20.2","11.9","52.44",0,"16.222",79060000,12,"0.303754",1,"5.62867","0.746458","sp|P51608|MECP2_HUMAN;tr|A0A087WXF0|A0A087WXF0_HUMAN;tr|A0A087X1U4|A0A087X1U4_HUMAN;tr|A0A087WVW7|A0A087WVW7_HUMAN;tr|A0A0D9SFX7|A0A0D9SFX7_HUMAN;tr|A0A0D9SEX1|A0A0D9SEX1_HUMAN;tr|C9JH89|C9JH89_HUMAN","sp|P51608|MECP2_HUMAN;tr|A0A087WXF0|A0A087WXF0_HUMAN;tr|A0A087X1U4|A0A087X1U4_HUMAN;tr|A0A087WVW7|A0A087WVW7_HUMAN",1743,"P51608","MECP2_HUMAN","Methyl-CpG-binding protein 2","eCp2;eCp-2 protein","MECP2"]
["17.1861","16.1765","17.6323",1,"15.6021","17.5126",{"$nulls":3},"ion transport;transport","inorganic phosphate transmembrane transporter activity;receptor activity;sodium:inorganic phosphate symporter activity;sodium:phosphate symporter activity;sodium-dependent phosphate transmembrane transporter activity;virus receptor activity","extracellular exosome;integral component of plasma membrane;membrane;plasma membrane",{"$nulls":3},2,2,2,"6.1","6.1","6.1","70.392","0.00041999","4.4759",15064000,3,"0.464982",1,"5.62673","1.07529","sp|Q08357|S20A2_HUMAN","sp|Q08357|S20A2_HUMAN",2229,"Q08357","S20A2_HUMAN","Sodium-dependent phosphate transporter 2",null,"SLC20A2"]
["19.7532","18.6742","17.0401","18.938","18.6782",1,{"$nulls":3},"cell cycle;mRNA methylation;mRNA processing;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA splicing",null,"nuclear membrane;nuclear speck;nucleoplasm;nucleus;RNA N6-methyladenosine methyltransferase complex",{"$nulls":3},5,5,5,"17.7","17.7","17.7","44.243",0,"53.473",146380000,15,"0.396456",1,"5.61712","0.937959","sp|Q15007|FL2D_HUMAN;tr|A0A087X1R4|A0A087X1R4_HUMAN","sp|Q15007|FL2D_HUMAN",2533,"Q15007","FL2D_HUMAN","Pre-mRNA-splicing regulator WTAP",null,"WTAP"]
["17.0987",1,"16.1247",1,1,"15.4088",{"$nulls":3},"axon guidance;insulin receptor signaling pathway;MAPK cascade","protein tyrosine phosphatase activity;Ras guanyl-nucleotide exchange factor activity;transmembrane receptor protein tyrosine phosphatase activity","extracellular exosome;integral component of plasma membrane;intracellular;plasma membrane;receptor complex",{"$nulls":3},4,4,4,"8.4","8.4","8.4","90.599",0,"11.641",14524000,3,"0.324879",1,"5.60486","0.790846","sp|P18433|PTPRA_HUMAN","sp|P18433|PTPRA_HUMAN",1177,"P18433","PTPRA_HUMAN","Receptor-type tyrosine-protein phosphatase alpha",{"$f":"-PTP-alpha,rotein-tyrosine phosphatase alpha","v":{"$error":"#NAME?"}},"PTPRA"]
["20.1935","16.8837",1,"19.2807",1,1,{"$nulls":5},"cytosol",{"$nulls":3},2,2,2,22,22,22,"21.556",0,"14.224",44104000,4,"0.2628",1,"5.59885","0.658814","tr|H0YNN4|H0YNN4_HUMAN;tr|H0YNB7|H0YNB7_HUMAN;tr|H0YL22|H0YL22_HUMAN;sp|Q9Y375|CIA30_HUMAN","tr|H0YNN4|H0YNN4_HUMAN;tr|H0YNB7|H0YNB7_HUMAN;tr|H0YL22|H0YL22_HUMAN;sp|Q9Y375|CIA30_HUMAN",5270,"H0YNN4","H0YNN4_HUMAN",null,null,"NDUFAF1"]
["19.7544","19.2607","18.209","20.2977","19.1378",1,{"$nulls":3},"cell-cell signaling;transmembrane receptor protein tyrosine kinase signaling pathway","structural molecule activity","cell surface;focal adhesion;integral component of plasma membrane","Cell adhesion molecules (CAMs)",null,null,5,5,5,"18.2","18.2","18.2","29.082",0,"11.521",73140000,10,"0.374483",1,"5.59618","0.89327","sp|O95297|MPZL1_HUMAN;tr|Q9UEL6|Q9UEL6_HUMAN","sp|O95297|MPZL1_HUMAN",737,"O95297","MPZL1_HUMAN","Myelin protein zero-like protein 1",null,"MPZL1"]
["21.3836","13.3263","19.1575",1,"17.677","18.435",{"$nulls":3},"adaptive immune response;antigen processing and presentation;antigen processing and presentation of exogenous peptide antigen via MHC class II;cellular response to thyroid hormone stimulus;collagen catabolic process;extracellular matrix disassembly;macrophage apoptotic process;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of keratinocyte differentiation;toll-like receptor signaling pathway","collagen binding;cysteine-type endopeptidase activity;cysteine-type peptidase activity;fibronectin binding;histone binding;proteoglycan binding;serine-type endopeptidase activity;serpin family protein binding","endolysosome lumen;extracellular exosome;extracellular region;extracellular space;lysosomal lumen;lysosome;nucleus","Antigen processing and presentation;Apoptosis;Autophagy - animal;Fluid shear stress and atherosclerosis;Lysosome;Phagosome;Proteoglycans in cancer;Rheumatoid arthritis",null,null,3,3,3,"13.2","13.2","13.2","37.564",0,"10.185",56149000,2,"0.379909",1,"5.58513","0.90434","sp|P07711|CATL1_HUMAN;sp|Q5NE16|CATL3_HUMAN;tr|Q5T8F0|Q5T8F0_HUMAN;tr|Q5QP40|Q5QP40_HUMAN;sp|P43235|CATK_HUMAN;sp|O60911|CATL2_HUMAN","sp|P07711|CATL1_HUMAN",940,"P07711","CATL1_HUMAN","Cathepsin L1",null,"CTSL"]
[1,"17.9261","17.7678",1,"17.9714",1,{"$nulls":3},"RNA methylation","methyltransferase activity",{"$nulls":4},4,4,4,"21.7","21.7","21.7","16.93",0,"9.4575",63344000,7,"0.28158",1,"5.57419","0.699286","tr|E9PGN6|E9PGN6_HUMAN;sp|Q9UI43|MRM2_HUMAN","tr|E9PGN6|E9PGN6_HUMAN;sp|Q9UI43|MRM2_HUMAN",5046,"E9PGN6","E9PGN6_HUMAN",null,null,"MRM2"]
["17.3043",1,"17.2806","16.8682",1,1,{"$nulls":4},"ATP binding;metal ion binding;sodium:potassium-exchanging ATPase activity","integral component of membrane",{"$nulls":3},17,3,1,"22.7","4.5","1.6","108.28",0,"5.9571",34698000,4,"0.298352",1,"5.57222","0.735024","tr|M0R116|M0R116_HUMAN;sp|P13637|AT1A3_HUMAN;tr|A0A0A0MT26|A0A0A0MT26_HUMAN;sp|Q13733|AT1A4_HUMAN","tr|M0R116|M0R116_HUMAN;sp|P13637|AT1A3_HUMAN;tr|A0A0A0MT26|A0A0A0MT26_HUMAN",1081,"M0R116","M0R116_HUMAN","Sodium/potassium-transporting ATPase subunit alpha {ECO:0000256|RuleBase:RU362084}",null,"ATP1A3"]
["19.4885","15.9943","17.6236","18.9732",1,"16.4172",{"$nulls":3},"astrocyte development;cell cycle arrest;cell dedifferentiation;cell division;cellular response to phorbol 13-acetate 12-myristate;dentate gyrus development;G1/S transition of mitotic cell cycle;generation of neurons;gliogenesis;lateral ventricle development;negative regulation of cell cycle;negative regulation of cell differentiation;negative regulation of cell proliferation;negative regulation of cellular senescence;negative regulation of epithelial cell proliferation;negative regulation of monocyte differentiation;negative regulation of myeloid cell differentiation;negative regulation of osteoblast differentiation;positive regulation of cell-matrix adhesion;positive regulation of fibroblast proliferation;protein phosphorylation;regulation of cell motility;regulation of erythrocyte differentiation;regulation of G2/M transition of mitotic cell cycle;regulation of gene expression;response to virus;signal transduction;type B pancreatic cell development","ATP binding;cyclin binding;cyclin-dependent protein serine/threonine kinase activity;FBXO family protein binding","centrosome;cyclin-dependent protein kinase holoenzyme complex;cytoplasm;cytosol;nucleoplasm;nucleus;ruffle","Breast cancer;Cell cycle;Cellular senescence;Chronic myeloid leukemia;Cushing syndrome;Epstein-Barr virus infection;Glioma;Hepatitis C;Hepatocellular carcinoma;Human cytomegalovirus infection;Human papillomavirus infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;Melanoma;MicroRNAs in cancer;Non-small cell lung cancer;p53 signaling pathway;Pancreatic cancer;Pathways in cancer;PI3K-Akt signaling pathway;Small cell lung cancer;Viral carcinogenesis",null,null,4,3,3,"17.2","14.7","14.7","36.938",0,"11.477",33896000,6,"0.41574",1,"5.57199","0.976891","sp|Q00534|CDK6_HUMAN","sp|Q00534|CDK6_HUMAN",2117,"Q00534","CDK6_HUMAN","Cyclin-dependent kinase 6",null,"CDK6"]
["19.6784","17.9829","17.1621","19.6298","17.4787",1,{"$nulls":3},"mRNA cis splicing, via spliceosome;mRNA splicing, via spliceosome","nucleic acid binding;proline-rich region binding;zinc ion binding","nuclear speck;nucleoplasm;spliceosomal complex",{"$nulls":3},2,2,2,"7.4","7.4","7.4","42.506","0.0004215","4.5826",48280000,2,"0.397194",1,"5.57165","0.939454","sp|O75554|WBP4_HUMAN","sp|O75554|WBP4_HUMAN",607,"O75554","WBP4_HUMAN","WW domain-binding protein 4","BP-4","WBP4"]
["16.4356","16.7625","14.4907",1,"15.4777","14.5232",{"$nulls":3},"mannose metabolic process","alpha-mannosidase activity;carbohydrate binding;metal ion binding",{"$nulls":4},2,2,2,"3.1","3.1","3.1","107.51",0,"5.7328",14376000,3,"0.516191",1,"5.56263","1.17643","tr|H0YA68|H0YA68_HUMAN;tr|E9PCD7|E9PCD7_HUMAN;sp|Q9Y2E5|MA2B2_HUMAN","tr|H0YA68|H0YA68_HUMAN;tr|E9PCD7|E9PCD7_HUMAN;sp|Q9Y2E5|MA2B2_HUMAN",5220,"H0YA68","H0YA68_HUMAN","Alpha-mannosidase {ECO:0000256|RuleBase:RU361199}",null,"MAN2B2"]
["17.1677","18.4433","18.2178","18.2325",1,"17.9302",{"$nulls":3},"cleavage furrow formation;endocytosis;endosomal transport;mitotic cytokinesis;positive regulation of GTPase activity;protein transport","phosphatidylinositol-4,5-bisphosphate binding","cytoplasmic vesicle;cytoplasmic vesicle membrane;endosome membrane;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane",{"$nulls":3},8,8,8,"19.1","19.1","19.1","68.894",0,"52.782",298940000,36,"0.413936",1,"5.55537","0.973259","sp|Q96RF0|SNX18_HUMAN","sp|Q96RF0|SNX18_HUMAN",4016,"Q96RF0","SNX18_HUMAN","Sorting nexin-18",null,"SNX18"]
["18.5795","17.476","16.6569","17.6417","17.4418",1,{"$nulls":3},"basement membrane organization;cell adhesion;establishment of epithelial cell polarity;keratinocyte migration;keratinocyte proliferation;negative regulation of canonical Wnt signaling pathway;negative regulation of catenin import into nucleus;negative regulation of gene expression;negative regulation of stem cell proliferation;negative regulation of timing of anagen;positive regulation of cell adhesion mediated by integrin;positive regulation of cell-matrix adhesion;positive regulation of transforming growth factor beta receptor signaling pathway;positive regulation of transforming growth factor-beta secretion",null,"cell junction;cytosol;filamentous actin;focal adhesion;ruffle membrane",{"$nulls":3},6,5,5,12,"10.5","10.5","77.436",0,"11.063",64548000,5,"0.427302",1,"5.54294","1.00012","sp|Q9BQL6|FERM1_HUMAN;tr|G3V1L6|G3V1L6_HUMAN","sp|Q9BQL6|FERM1_HUMAN;tr|G3V1L6|G3V1L6_HUMAN",4152,"Q9BQL6","FERM1_HUMAN","Fermitin family homolog 1",null,"FERMT1"]
["17.3375","17.3283",1,1,"17.0391",1,{"$nulls":3},"mitochondrial ornithine transport;mitochondrial transport;urea cycle","L-ornithine transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane",{"$nulls":3},2,2,2,"9.3","9.3","9.3","32.736","0.0010085","3.6843",14852000,2,"0.294256",1,"5.54223","0.726331","sp|Q9Y619|ORNT1_HUMAN;tr|Q5VZD9|Q5VZD9_HUMAN","sp|Q9Y619|ORNT1_HUMAN;tr|Q5VZD9|Q5VZD9_HUMAN",5385,"Q9Y619","ORNT1_HUMAN","Mitochondrial ornithine transporter 1",null,"SLC25A15"]
["18.2177","17.6584","17.2458","18.3051","17.2056",1,{"$nulls":3},"lysosome localization",null,"BORC complex;lysosomal membrane",{"$nulls":3},3,3,3,"13.7","13.7","13.7","37.226",0,"7.8868",25219000,5,"0.421536",1,"5.53705","0.988544","sp|Q96GS4|CQ059_HUMAN","sp|Q96GS4|CQ059_HUMAN",3902,"Q96GS4","BORC6_HUMAN","BLOC-1-related complex subunit 6 {ECO:0000305}",null,"BORCS6"]
["18.3235","13.0701","17.3591",1,"13.1618","18.0073",{"$nulls":3},"cerebellum morphogenesis;ether lipid biosynthetic process;membrane organization;paranodal junction assembly;phosphatidic acid biosynthetic process;response to drug;response to fatty acid;response to nutrient;response to starvation;synapse assembly","glycerone-phosphate O-acyltransferase activity;palmitoyl-CoA hydrolase activity;receptor binding","membrane;mitochondrion;peroxisomal matrix;peroxisomal membrane;peroxisome","Glycerophospholipid metabolism;Peroxisome",null,null,4,4,4,"9.3","9.3","9.3","77.187",0,"27.442",44047000,8,"0.447748",1,"5.52788","1.041","sp|O15228|GNPAT_HUMAN;tr|Q5TBH8|Q5TBH8_HUMAN;tr|Q5TBH6|Q5TBH6_HUMAN","sp|O15228|GNPAT_HUMAN;tr|Q5TBH8|Q5TBH8_HUMAN;tr|Q5TBH6|Q5TBH6_HUMAN",348,"O15228","GNPAT_HUMAN","Dihydroxyacetone phosphate acyltransferase","AP-AT;HAP-AT","GNPAT"]
[1,"18.0577","16.5875",1,"17.0857",1,{"$nulls":3},"lysine catabolic process;negative regulation of transcription from RNA polymerase II promoter;sensory perception of sound;thyroid hormone metabolic process;thyroid hormone transport","NADP binding;oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor;protein homodimerization activity;thiomorpholine-carboxylate dehydrogenase activity;thyroid hormone binding;transcription corepressor activity","cytoplasm;cytosol;extracellular exosome;mitochondrion;nucleus;peroxisomal matrix",{"$nulls":3},3,3,3,"11.8","11.8","11.8","33.775",0,"7.4516",27789000,4,"0.291978",1,"5.51986","0.721486","sp|Q14894|CRYM_HUMAN;tr|I3NI53|I3NI53_HUMAN;tr|I3L2W5|I3L2W5_HUMAN;tr|I3L325|I3L325_HUMAN;tr|I3L3J9|I3L3J9_HUMAN;tr|I3L3Y1|I3L3Y1_HUMAN","sp|Q14894|CRYM_HUMAN;tr|I3NI53|I3NI53_HUMAN;tr|I3L2W5|I3L2W5_HUMAN;tr|I3L325|I3L325_HUMAN",2513,"Q14894","CRYM_HUMAN","Ketimine reductase mu-crystallin",null,"CRYM"]
["17.2165","13.6624",1,1,"13.3796",1,{"$nulls":4},"metallocarboxypeptidase activity;zinc ion binding",{"$nulls":4},3,3,3,"13.9","13.9","13.9","35.634",0,"5.6214",5043400,3,"0.356468",1,"5.49975","0.856337","tr|B7Z5J4|B7Z5J4_HUMAN;sp|Q9UI42|CBPA4_HUMAN","tr|B7Z5J4|B7Z5J4_HUMAN;sp|Q9UI42|CBPA4_HUMAN",5045,"B7Z5J4","B7Z5J4_HUMAN",null,null,"CPA4"]
["17.6445","13.0002","17.4764",1,"12.5407","18.0828",{"$nulls":4},"potassium:chloride symporter activity","integral component of membrane",{"$nulls":3},3,3,3,"3.7","3.7","3.7","115.05",0,"5.6365",33140000,7,"0.45034",1,"5.4992","1.04617","tr|I3L4N6|I3L4N6_HUMAN;sp|Q9UP95|S12A4_HUMAN;tr|H0YMQ9|H0YMQ9_HUMAN;tr|H0YKQ8|H0YKQ8_HUMAN;tr|B3KXX3|B3KXX3_HUMAN;sp|Q9UHW9|S12A6_HUMAN","tr|I3L4N6|I3L4N6_HUMAN;sp|Q9UP95|S12A4_HUMAN",5170,"I3L4N6","I3L4N6_HUMAN",null,null,"SLC12A4"]
[1,"13.924","18.2937",1,"14.7291",1,{"$nulls":4},"transcription cofactor activity","fibrillar center;SAGA complex",{"$nulls":3},7,7,7,"14.4","14.4","14.4","80.343",0,"19.076",142370000,23,"0.326458",1,"5.49618","0.794144","tr|F6S7C4|F6S7C4_HUMAN;sp|Q8NEM7|SP20H_HUMAN;tr|B4E2D5|B4E2D5_HUMAN;tr|R4GND2|R4GND2_HUMAN;tr|H7C5F9|H7C5F9_HUMAN;tr|C9JQS2|C9JQS2_HUMAN","tr|F6S7C4|F6S7C4_HUMAN;sp|Q8NEM7|SP20H_HUMAN;tr|B4E2D5|B4E2D5_HUMAN;tr|R4GND2|R4GND2_HUMAN;tr|H7C5F9|H7C5F9_HUMAN",3492,"F6S7C4","F6S7C4_HUMAN",null,null,"SUPT20H"]
["16.8664",1,"17.0085","16.3907",1,1,{"$nulls":3},"bile acid and bile salt transport;camera-type eye development;cardiac muscle cell proliferation;cholesterol metabolic process;embryo implantation;in utero embryonic development;maternal placenta development;modulation by virus of host morphology or physiology;negative regulation of transcription from RNA polymerase II promoter;peroxisome proliferator activated receptor signaling pathway;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;positive regulation of translational initiation by iron;protein homotetramerization;regulation of branching involved in prostate gland morphogenesis;regulation of lipid metabolic process;response to retinoic acid;retinoic acid receptor signaling pathway;secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;transcription initiation from RNA polymerase II promoter;ventricular cardiac muscle cell differentiation;ventricular cardiac muscle tissue morphogenesis;vitamin metabolic process","9-cis retinoic acid receptor activity;chromatin DNA binding;DBD domain binding;DNA binding;DNA binding transcription factor activity;double-stranded DNA binding;enzyme binding;LBD domain binding;ligand-dependent nuclear receptor binding;nuclear receptor activity;peptide binding;protein heterodimerization activity;retinoic acid binding;retinoic acid receptor activity;retinoic acid-responsive element binding;RNA polymerase II regulatory region sequence-specific DNA binding;sequence-specific DNA binding;steroid hormone receptor activity;transcription coactivator activity;vitamin D receptor binding;zinc ion binding","nuclear chromatin;nucleoplasm;nucleus;protein complex;receptor complex;RNA polymerase II transcription factor complex","Adipocytokine signaling pathway;Bile secretion;Gastric cancer;Hepatitis C;Non-alcoholic fatty liver disease (NAFLD);Non-small cell lung cancer;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;PI3K-Akt signaling pathway;PPAR signaling pathway;Small cell lung cancer;Th17 cell differentiation;Thyroid cancer;Thyroid hormone signaling pathway;Transcriptional misregulation in cancer",null,null,2,1,1,"6.7","4.5","4.5","50.811","0.0011851","3.3773",14543000,3,"0.302592",1,"5.49474","0.744003","sp|P19793|RXRA_HUMAN","sp|P19793|RXRA_HUMAN",1199,"P19793","RXRA_HUMAN","Retinoic acid receptor RXR-alpha",null,"RXRA"]
["16.1201",1,"16.5511","15.2001",1,1,{"$nulls":3},"cell cycle;chromosome segregation;double-strand break repair;hematopoietic progenitor cell differentiation;post-translational protein acetylation;protein localization to chromatin;regulation of DNA replication","lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;metal ion binding;N-acetyltransferase activity","cell junction;chromatin;chromocenter;Golgi apparatus;nuclear pericentric heterochromatin;nucleoplasm;nucleus;site of double-strand break;XY body",{"$nulls":3},3,3,1,"7.3","7.3","2.5","68.306",0,"8.3659",24007000,5,"0.323496",1,"5.49038","0.787956","sp|Q56NI9|ESCO2_HUMAN;tr|E5RFE4|E5RFE4_HUMAN","sp|Q56NI9|ESCO2_HUMAN",2794,"Q56NI9","ESCO2_HUMAN","N-acetyltransferase ESCO2",null,"ESCO2"]
["16.8243","15.7027","17.6178",1,"15.0386","17.6357",{"$nulls":3},"cell morphogenesis involved in neuron differentiation;negative regulation of cytoplasmic translation;neuron migration","metal ion binding;mRNA CDS binding;RNA binding","cytoplasm;polysome",{"$nulls":3},3,3,3,"5.3","5.3","5.3","88.084","0.0057322","2.4118",32501000,2,"0.455501",1,"5.49015","1.05644","sp|Q9C0B0|UNK_HUMAN;tr|A0A0A0MRZ1|A0A0A0MRZ1_HUMAN;tr|E9PDK2|E9PDK2_HUMAN","sp|Q9C0B0|UNK_HUMAN",4346,"Q9C0B0","UNK_HUMAN","RING finger protein unkempt homolog",null,"UNK"]
["15.9089","21.0698","21.0693","19.8223","20.7652",1,{"$nulls":3},"positive regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","protein dimerization activity;RNA polymerase II regulatory region sequence-specific DNA binding","nucleus",{"$nulls":3},1,1,1,"12.9","12.9","12.9","10.058","0.00061678","4.0776",59128000,4,"0.340565",1,"5.48684","0.823491","tr|H0YM62|H0YM62_HUMAN;tr|D6RG14|D6RG14_HUMAN;tr|D6RB91|D6RB91_HUMAN;tr|D6RG21|D6RG21_HUMAN;tr|D6RCM6|D6RCM6_HUMAN;tr|Q05BX2|Q05BX2_HUMAN;tr|D6RJA7|D6RJA7_HUMAN;tr|A0A0D9SET2|A0A0D9SET2_HUMAN;tr|D6R942|D6R942_HUMAN;tr|D6RC63|D6RC63_HUMAN;tr|D8L7E9|D8L7E9_HUMAN;tr|D6RJG6|D6RJG6_HUMAN;tr|A0A0D9SFD0|A0A0D9SFD0_HUMAN;tr|A0A0D9SGI5|A0A0D9SGI5_HUMAN;sp|Q06413|MEF2C_HUMAN;sp|Q02078|MEF2A_HUMAN;sp|Q14814|MEF2D_HUMAN","tr|H0YM62|H0YM62_HUMAN;tr|D6RG14|D6RG14_HUMAN;tr|D6RB91|D6RB91_HUMAN;tr|D6RG21|D6RG21_HUMAN;tr|D6RCM6|D6RCM6_HUMAN;tr|Q05BX2|Q05BX2_HUMAN;tr|D6RJA7|D6RJA7_HUMAN;tr|A0A0D9SET2|A0A0D9SET2_HUMAN;tr|D6R942|D6R942_HUMAN;tr|D6RC63|D6RC63_HUMAN;tr|D8L7E9|D8L7E9_HUMAN;tr|D6RJG6|D6RJG6_HUMAN;tr|A0A0D9SFD0|A0A0D9SFD0_HUMAN;tr|A0A0D9SGI5|A0A0D9SGI5_HUMAN;sp|Q06413|MEF2C_HUMAN;sp|Q02078|MEF2A_HUMAN;sp|Q14814|MEF2D_HUMAN",2151,"H0YM62","H0YM62_HUMAN",null,null,"MEF2A"]
["18.2447","15.4789","16.5365","17.3892","15.4455",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"5.9","5.9","5.9","50.552","0.0011825","3.345",18670000,0,"0.450487",1,"5.47514","1.04646","tr|K7EPA3|K7EPA3_HUMAN;sp|Q9NX61|T161A_HUMAN;tr|K7EQ34|K7EQ34_HUMAN;tr|U3KQT6|U3KQT6_HUMAN","tr|K7EPA3|K7EPA3_HUMAN;sp|Q9NX61|T161A_HUMAN;tr|K7EQ34|K7EQ34_HUMAN;tr|U3KQT6|U3KQT6_HUMAN",4816,"K7EPA3","K7EPA3_HUMAN",null,null,"TMEM161A"]
["18.0313","17.2194",1,"17.8507",1,1,{"$nulls":3},"ribosomal large subunit biogenesis;ribosome assembly","RNA binding","cytosol;nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},3,3,3,"21.7","21.7","21.7","20.462",0,"6.3596",13966000,1,"0.278418",1,"5.46666","0.692506","sp|Q9Y221|NIP7_HUMAN;tr|J3QRD6|J3QRD6_HUMAN;tr|J3QRR4|J3QRR4_HUMAN;tr|J3QLW7|J3QLW7_HUMAN","sp|Q9Y221|NIP7_HUMAN;tr|J3QRD6|J3QRD6_HUMAN;tr|J3QRR4|J3QRR4_HUMAN;tr|J3QLW7|J3QLW7_HUMAN",5194,"Q9Y221","NIP7_HUMAN","60S ribosome subunit biogenesis protein NIP7 homolog",null,"NIP7"]
["16.9866","15.552",1,1,"15.1967",1,{"$nulls":3},"CDP-diacylglycerol biosynthetic process","glycerol-3-phosphate O-acyltransferase activity;sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity","mitochondrial outer membrane;plasma membrane",{"$nulls":3},14,14,14,"34.1","34.1","34.1","80.139",0,"44.484",151790000,34,"0.32085",1,"5.4473","0.782419","tr|Q5VW52|Q5VW52_HUMAN;sp|Q9HCL2|GPAT1_HUMAN","tr|Q5VW52|Q5VW52_HUMAN;sp|Q9HCL2|GPAT1_HUMAN",4598,"Q5VW52","Q5VW52_HUMAN","Glycerol-3-phosphate acyltransferase 1, mitochondrial {ECO:0000256|PIRNR:PIRNR000437}"]
["16.7055",1,"17.0454",1,1,"16.4109",{"$nulls":3},"mitochondrial tRNA thio-modification;tRNA wobble position uridine thiolation","ATP binding;sulfurtransferase activity;tRNA binding","mitochondrion;nucleoplasm",{"$nulls":3},4,4,4,"9.7","9.7","9.7","47.744",0,"8.756",17812000,3,"0.299973",1,"5.44667","0.73846","sp|O75648|MTU1_HUMAN","sp|O75648|MTU1_HUMAN",618,"O75648","MTU1_HUMAN","Mitochondrial tRNA-specific 2-thiouridylase 1",null,"TRMU"]
["16.9065","14.8513","16.8617","17.0178","14.2648",1,{"$nulls":3},"acetyl-CoA biosynthetic process;acyl-CoA metabolic process;fatty acid biosynthetic process;fatty acid oxidation;malonyl-CoA catabolic process;positive regulation of fatty acid oxidation;regulation of fatty acid beta-oxidation;regulation of glucose metabolic process;response to ischemia","identical protein binding;malonyl-CoA decarboxylase activity;receptor binding","cytoplasm;cytosol;mitochondrial matrix;mitochondrion;peroxisomal matrix;peroxisome","AMPK signaling pathway;beta-Alanine metabolism;Metabolic pathways;Peroxisome;Propanoate metabolism",null,null,3,3,3,"8.7","8.7","8.7","55.003","0.0004158","4.2653",16110000,4,"0.472954",1,"5.44562","1.0911","sp|O95822|DCMC_HUMAN","sp|O95822|DCMC_HUMAN",797,"O95822","DCMC_HUMAN","Malonyl-CoA decarboxylase, mitochondrial","CD","MLYCD"]
["17.2954","15.9235","17.7126",1,"16.3075","17.2914",{"$nulls":3},"androgen metabolic process;B cell receptor signaling pathway;cellular response to hydrogen peroxide;establishment of protein localization;estrogen metabolic process;face morphogenesis;Leydig cell differentiation;luteinization;multicellular organism growth;negative regulation of protein kinase B signaling;palate development;phosphatidylinositol 3-kinase signaling;phosphatidylinositol biosynthetic process;platelet-derived growth factor receptor signaling pathway;post-embryonic development;ruffle organization;skeletal system morphogenesis;spermatogenesis","PDZ domain binding;phosphatidylinositol-3,4-bisphosphate binding","cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;plasma membrane;ruffle membrane",{"$nulls":3},5,5,5,"16.1","16.1","16.1","45.553",0,"10.43",37073000,5,"0.440669",1,"5.44422","1.02687","sp|Q9HB21|PKHA1_HUMAN;tr|Q5RGS4|Q5RGS4_HUMAN","sp|Q9HB21|PKHA1_HUMAN;tr|Q5RGS4|Q5RGS4_HUMAN",4567,"Q9HB21","PKHA1_HUMAN","Pleckstrin homology domain-containing family A member 1","H domain-containing family A member 1","PLEKHA1"]
["17.2072","16.6648",1,1,"16.5502",1,{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;nucleotide metabolic process","5'-nucleotidase activity;magnesium ion binding;nucleotide binding","cytosol","Metabolic pathways;Nicotinate and nicotinamide metabolism;Purine metabolism;Pyrimidine metabolism",null,null,2,2,2,"5.7","5.7","5.7","34.389","0.0030189","2.7229",13557000,2,"0.297342",1,"5.44061","0.732881","sp|Q969T7|5NT3B_HUMAN;tr|E5RJR6|E5RJR6_HUMAN;tr|U3KQB1|U3KQB1_HUMAN;tr|E5RH64|E5RH64_HUMAN;tr|C9J758|C9J758_HUMAN","sp|Q969T7|5NT3B_HUMAN;tr|E5RJR6|E5RJR6_HUMAN;tr|U3KQB1|U3KQB1_HUMAN;tr|E5RH64|E5RH64_HUMAN;tr|C9J758|C9J758_HUMAN",3768,"Q969T7","5NT3B_HUMAN","7-methylguanosine phosphate-specific 5'-nucleotidase {ECO:0000305|PubMed:23223233}",{"$f":"-methylguanosine nucleotidase","v":{"$error":"#NAME?"}},"NT5C3B"]
["18.3338","17.594",1,"18.6212",1,1,{"$nulls":3},"post-translational protein modification;protein ubiquitination",null,"Cul4-RING E3 ubiquitin ligase complex;nucleoplasm",{"$nulls":3},3,3,3,"18.1","18.1","18.1","24.193",0,"6.8227",16265000,5,"0.266322",1,"5.43554","0.666443","sp|Q9NXF7|DCA16_HUMAN","sp|Q9NXF7|DCA16_HUMAN",4825,"Q9NXF7","DCA16_HUMAN","DDB1- and CUL4-associated factor 16",null,"DCAF16"]
["17.3679",1,"16.6035",1,1,"16.6686",{"$nulls":3},"heparan sulfate proteoglycan biosynthetic process;IRE1-mediated unfolded protein response;N-acetylglucosamine metabolic process;UDP-N-acetylgalactosamine metabolic process","alpha-1,4-N-acetylgalactosaminyltransferase activity;glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;glycosaminoglycan binding;manganese ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane","Glycosaminoglycan biosynthesis - heparan sulfate / heparin;Metabolic pathways",null,null,3,3,3,"12.4","12.4","12.4","37.465",0,"15.888",38803000,4,"0.295045",1,"5.43429","0.728005","sp|Q9UBQ6|EXTL2_HUMAN;tr|C9IYF5|C9IYF5_HUMAN;tr|F5GZK1|F5GZK1_HUMAN;tr|C9JEG3|C9JEG3_HUMAN","sp|Q9UBQ6|EXTL2_HUMAN;tr|C9IYF5|C9IYF5_HUMAN;tr|F5GZK1|F5GZK1_HUMAN;tr|C9JEG3|C9JEG3_HUMAN",4969,"Q9UBQ6","EXTL2_HUMAN","Exostosin-like 2",null,"EXTL2"]
["17.1205",1,"16.2422",1,1,"16.0687",{"$nulls":3},"axon guidance;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;leukocyte migration;negative regulation of translation;positive regulation of cell migration;stress granule assembly","identical protein binding;phosphatidylinositol binding;protein kinase binding;RNA binding;SH3/SH2 adaptor activity","cell projection;cytoplasmic stress granule;cytosol;focal adhesion;plasma membrane",{"$nulls":3},3,3,3,9,9,9,"59.68","0.00061513","3.9762",23814000,0,"0.304847",1,"5.43136","0.748768","sp|Q14451|GRB7_HUMAN","sp|Q14451|GRB7_HUMAN",2473,"Q14451","GRB7_HUMAN","Growth factor receptor-bound protein 7",null,"GRB7"]
["16.097","18.0466","16.3443","17.0178",1,"16.1986",{"$nulls":3},"cellular zinc ion homeostasis;nucleotide-excision repair;positive regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;zinc II ion transport","cation transmembrane transporter activity;chromatin binding;DNA binding transcription factor activity;ligand-dependent nuclear receptor binding;ligand-dependent nuclear receptor transcription coactivator activity","cytoplasmic vesicle;cytoskeleton;endoplasmic reticulum;integral component of membrane;nucleus",{"$nulls":3},2,2,2,"3.7","3.7","3.7","63.514",0,"6.4815",57440000,5,"0.444384",1,"5.42385","1.03429","sp|Q6PML9|ZNT9_HUMAN","sp|Q6PML9|ZNT9_HUMAN",3043,"Q6PML9","ZNT9_HUMAN","Zinc transporter 9","nT-9","SLC30A9"]
[1,"15.3566","17.2762",1,"15.3722",1,{"$nulls":3},"neutrophil degranulation","RNA binding","extracellular region;ficolin-1-rich granule lumen;secretory granule lumen",{"$nulls":3},5,5,5,"20.2","20.2","20.2","29.411",0,"20.47",83458000,16,"0.315769",1,"5.42021","0.771767","sp|Q9BU76|MMTA2_HUMAN","sp|Q9BU76|MMTA2_HUMAN",4220,"Q9BU76","MMTA2_HUMAN","Multiple myeloma tumor-associated protein 2","MMTAG2","MMTAG2"]
["17.7822","14.6485","16.1341","17.3966","13.9202",1,{"$nulls":5},"nucleoplasm",{"$nulls":3},2,2,2,"3.3","3.3","3.3","78.77",0,"7.758",26937000,2,"0.461487",1,"5.41603","1.06835","tr|J3KMX1|J3KMX1_HUMAN;sp|Q99567|NUP88_HUMAN;tr|I3L245|I3L245_HUMAN","tr|J3KMX1|J3KMX1_HUMAN;sp|Q99567|NUP88_HUMAN;tr|I3L245|I3L245_HUMAN",4078,"J3KMX1","J3KMX1_HUMAN",null,null,"NUP88"]
["17.338","17.1917",1,1,"17.2918",1,{"$nulls":3},"vesicle-mediated transport","guanyl-nucleotide exchange factor activity","aggresome;cytosol;intracellular membrane-bounded organelle;lysosomal membrane;vesicle",{"$nulls":3},4,4,4,"9.1","9.1","9.1","55.866",0,"8.0575",273200000,7,"0.28441",1,"5.41263","0.705341","sp|P86791|CCZ1_HUMAN;sp|P86790|CCZ1B_HUMAN;tr|F8WD66|F8WD66_HUMAN","sp|P86791|CCZ1_HUMAN;sp|P86790|CCZ1B_HUMAN",2104,"P86791","CCZ1_HUMAN","Vacuolar fusion protein CCZ1 homolog",null,"CCZ1"]
["16.922",1,"17.0359","16.7385",1,1,{"$nulls":9},1,1,1,4,4,4,"43.937","0.0008185","3.9478",14584000,6,"0.292765",1,"5.40645","0.72316","tr|F8VX22|F8VX22_HUMAN;tr|F8VW41|F8VW41_HUMAN;sp|Q86VP3|PACS2_HUMAN","tr|F8VX22|F8VX22_HUMAN;tr|F8VW41|F8VW41_HUMAN;sp|Q86VP3|PACS2_HUMAN",3233,"F8VX22"]
["18.092",1,"17.4626","18.3505",1,1,{"$nulls":3},"angiogenesis;blood vessel development;cell adhesion;negative regulation of Notch signaling pathway;positive regulation of endothelial cell proliferation;vasculogenesis","calcium ion binding","extracellular matrix;extracellular region;extracellular space",{"$nulls":3},2,2,2,"9.9","9.9","9.9","29.617","0.0048435","2.5228",13656000,2,"0.268528",1,"5.40136","0.671212","sp|Q9UHF1|EGFL7_HUMAN","sp|Q9UHF1|EGFL7_HUMAN",5022,"Q9UHF1","EGFL7_HUMAN","Epidermal growth factor-like protein 7","GF-like protein 7","EGFL7"]
["17.6526","16.0667","15.8417","16.7906","15.5824",1,{"$nulls":3},"glutathione biosynthetic process;glutathione metabolic process","5-oxoprolinase (ATP-hydrolyzing) activity;ATP binding","cytosol","Glutathione metabolism;Metabolic pathways",null,null,7,7,7,"7.8","7.8","7.8","137.46",0,"24.386",53935000,13,"0.455672",1,"5.39598","1.05678","sp|O14841|OPLA_HUMAN;tr|A0A087WY99|A0A087WY99_HUMAN","sp|O14841|OPLA_HUMAN",300,"O14841","OPLA_HUMAN","5-oxoprolinase",null,"OPLAH"]
["18.1986","16.4825","17.6168","17.5961",1,"17.5467",{"$nulls":3},"cell differentiation;fatty acid metabolic process;negative regulation of sequestering of triglyceride;phosphatidic acid biosynthetic process;positive regulation of lipoprotein lipase activity;positive regulation of triglyceride catabolic process","1-acylglycerol-3-phosphate O-acyltransferase activity;lysophosphatidic acid acyltransferase activity","cytosol;lipid droplet","Regulation of lipolysis in adipocytes",null,null,3,3,3,12,12,12,"39.095","0.00042799","4.921",25866000,3,"0.41274",1,"5.38507","0.970851","sp|Q8WTS1|ABHD5_HUMAN;tr|F8W7B5|F8W7B5_HUMAN;tr|H7BZY9|H7BZY9_HUMAN","sp|Q8WTS1|ABHD5_HUMAN",3590,"Q8WTS1","ABHD5_HUMAN","1-acylglycerol-3-phosphate O-acyltransferase ABHD5",null,"ABHD5"]
["17.1085",1,"17.1313","17.1021",1,1,{"$nulls":3},"chromatin assembly or disassembly",null,"nucleolus;nucleus",{"$nulls":3},5,5,5,"12.8","12.8","12.8","61.956",0,"80.124",61377000,6,"0.285785",1,"5.37925","0.708281","sp|Q9BW71|HIRP3_HUMAN","sp|Q9BW71|HIRP3_HUMAN",4271,"Q9BW71","HIRP3_HUMAN","HIRA-interacting protein 3",null,"HIRIP3"]
["17.1807","15.3001","15.3226","16.3011","14.4008",1,{"$nulls":3},"muscle contraction;muscle organ development;neuromuscular junction development;positive regulation of cell-matrix adhesion;regulation of sodium ion transmembrane transporter activity;response to denervation involved in regulation of muscle adaptation","actin binding;actin filament binding;integrin binding;protein kinase binding;vinculin binding;zinc ion binding","cell junction;cortical actin cytoskeleton;cytoplasm;cytoskeleton;dystrophin-associated glycoprotein complex;extracellular exosome;filopodium;filopodium membrane;growth cone;membrane;neuromuscular junction;nucleoplasm;plasma membrane;postsynaptic membrane;protein complex;sarcolemma",{"$nulls":3},15,15,15,"6.2","6.2","6.2","394.46",0,"44.879",163950000,20,"0.480203",1,"5.36716","1.10546","sp|P46939|UTRO_HUMAN;tr|Q5T097|Q5T097_HUMAN;tr|A0A0D9SG57|A0A0D9SG57_HUMAN","sp|P46939|UTRO_HUMAN",1606,"P46939","UTRO_HUMAN","Utrophin",null,"UTRN"]
["18.5165","16.2051",1,1,1,"17.6347",{"$nulls":3},"histone H2A acetylation;histone H3-K14 acetylation;histone H4-K12 acetylation;histone H4-K5 acetylation;histone H4-K8 acetylation;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;transcription, DNA-templated",null,"condensed chromosome kinetochore;cytosol;kinetochore;MOZ/MORF histone acetyltransferase complex;NuA4 histone acetyltransferase complex;nuclear body;nucleolus;nucleoplasm",{"$nulls":3},2,2,2,"17.8","17.8","17.8","21.635",0,"9.422",60833000,10,"0.275831",1,"5.36228","0.68695","sp|Q9HAF1|EAF6_HUMAN;tr|B1AK63|B1AK63_HUMAN","sp|Q9HAF1|EAF6_HUMAN;tr|B1AK63|B1AK63_HUMAN",4557,"Q9HAF1","EAF6_HUMAN","Chromatin modification-related protein MEAF6","YST/Esa1-associated factor 6","MEAF6"]
["16.7855","16.0812",1,1,"15.7879",1,{"$nulls":3},"mRNA processing;negative regulation of phosphatase activity","metal ion binding;RNA binding",{"$nulls":4},16,1,1,"17.9","1.5","1.5","113.6","0.0028388","2.7725",18169000,3,"0.306345",1,"5.35956","0.75193","sp|Q5T8P6|RBM26_HUMAN;tr|E2PSN0|E2PSN0_HUMAN","sp|Q5T8P6|RBM26_HUMAN",2878,"Q5T8P6","RBM26_HUMAN","RNA-binding protein 26",null,"RBM26"]
["18.7417",1,"17.6315","19.3026",1,1,{"$nulls":3},"protein folding","unfolded protein binding","cytosol;peroxisomal membrane",{"$nulls":3},4,4,4,"23.3","23.3","23.3","33.526",0,"58.132",36037000,13,"0.253975",1,"5.35687","0.639614","sp|Q99614|TTC1_HUMAN;tr|H0YB37|H0YB37_HUMAN","sp|Q99614|TTC1_HUMAN;tr|H0YB37|H0YB37_HUMAN",4088,"Q99614","TTC1_HUMAN","Tetratricopeptide repeat protein 1","PR repeat protein 1","TTC1"]
["17.7079","15.6426","17.0924",1,"15.8056","17.5681",{"$nulls":3},"amyloid precursor protein metabolic process;cholesterol homeostasis;cholesterol metabolic process;cholesterol transport;low-density lipoprotein particle clearance;membrane organization;positive regulation of cholesterol metabolic process;positive regulation of receptor-mediated endocytosis;positive regulation of receptor-mediated endocytosis involved in cholesterol transport;receptor internalization;receptor-mediated endocytosis;receptor-mediated endocytosis involved in cholesterol transport;regulation of protein binding;regulation of protein localization to plasma membrane","amyloid-beta binding;AP-2 adaptor complex binding;clathrin adaptor activity;clathrin binding;low-density lipoprotein particle receptor binding;phosphatidylinositol-4,5-bisphosphate binding;phosphotyrosine residue binding;receptor signaling complex scaffold activity;signaling adaptor activity","axon;basal plasma membrane;clathrin-coated vesicle membrane;cytoplasmic side of plasma membrane;cytosol;early endosome;neurofilament;plasma membrane;recycling endosome","Cholesterol metabolism;Endocytosis",null,null,1,1,1,"5.2","5.2","5.2","33.885","0.0011998","3.5629",22734000,2,"0.43359",1,"5.35644","1.01272","sp|Q5SW96|ARH_HUMAN","sp|Q5SW96|ARH_HUMAN",2853,"Q5SW96","ARH_HUMAN","Low density lipoprotein receptor adapter protein 1 {ECO:0000305}",null,"LDLRAP1"]
["17.0889","15.7191","15.2477","16.3962","14.6192",1,{"$nulls":4},"calcium ion binding",{"$nulls":4},4,4,4,"4.8","4.8","4.8","128.11",0,"8.0772",33388000,9,"0.473633",1,"5.34675","1.09245","tr|J3KN75|J3KN75_HUMAN;sp|Q0IIM8|TBC8B_HUMAN;tr|H0Y552|H0Y552_HUMAN","tr|J3KN75|J3KN75_HUMAN;sp|Q0IIM8|TBC8B_HUMAN;tr|H0Y552|H0Y552_HUMAN",2247,"J3KN75","J3KN75_HUMAN",null,null,"TBC1D8B"]
["17.6646","16.6447","17.2659",1,"16.7032","17.8372",{"$nulls":3},"ubiquitin-dependent ERAD pathway",null,"endoplasmic reticulum;integral component of membrane;nucleolus",{"$nulls":3},1,1,1,"6.3","6.3","6.3","30.529","0.00041606","4.2754",24953000,7,"0.418419",1,"5.34495","0.98228","tr|A0A087WV67|A0A087WV67_HUMAN;sp|O00124|UBXN8_HUMAN;tr|A0A087WT23|A0A087WT23_HUMAN","tr|A0A087WV67|A0A087WV67_HUMAN;sp|O00124|UBXN8_HUMAN;tr|A0A087WT23|A0A087WT23_HUMAN",200,"A0A087WV67","A0A087WV67_HUMAN",null,null,"UBXN8"]
["19.419","16.7044","19.0181","19.9058",1,"18.2757",{"$nulls":4},"metal ion binding;superoxide dismutase activity",{"$nulls":4},1,1,1,"19.1","19.1","19.1","7.2852","0.0011966","3.5253",32492000,7,"0.363636",1,"5.32","0.871066","tr|E9PP76|E9PP76_HUMAN;tr|J3KNF4|J3KNF4_HUMAN;sp|O14618|CCS_HUMAN","tr|E9PP76|E9PP76_HUMAN;tr|J3KNF4|J3KNF4_HUMAN;sp|O14618|CCS_HUMAN",276,"E9PP76","E9PP76_HUMAN",null,null,"CCS"]
["16.5261","16.0604","16.4179",1,"15.6006","16.4698",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"4.4","4.4","4.4","67.909","0.00041545","4.2382",12436000,4,"0.4563",1,"5.31131","1.05803","sp|Q5TGY1|TMCO4_HUMAN","sp|Q5TGY1|TMCO4_HUMAN",2887,"Q5TGY1","TMCO4_HUMAN","Transmembrane and coiled-coil domain-containing protein 4",null,"TMCO4"]
["16.1966","13.3083",1,1,"12.5727",1,{"$nulls":3},"defense response to virus;innate immune response;positive regulation of innate immune response;positive regulation of interferon-beta production;positive regulation of type I interferon production;transcription from RNA polymerase III promoter","DNA binding;DNA-directed 5'-3' RNA polymerase activity;metal ion binding;ribonucleoside binding","cytosol;DNA-directed RNA polymerase III complex;nucleoplasm","Cytosolic DNA-sensing pathway;RNA polymerase",null,null,1,1,1,"2.3","2.3","2.3","127.78","0.00042337","4.6445",5511700,1,"0.366995",1,"5.31075","0.877952","sp|Q9NW08|RPC2_HUMAN","sp|Q9NW08|RPC2_HUMAN",4782,"Q9NW08","RPC2_HUMAN","DNA-directed RNA polymerase III subunit RPC2","NA polymerase III subunit C2","POLR3B"]
["16.4178","15.1925","17.9601",1,"14.9032","17.747",{"$nulls":4},"hydrolase activity;metal ion binding","extracellular exosome",{"$nulls":3},3,3,3,"14.7","14.7","14.7","31.371",0,"6.4917",15656000,1,"0.434033",1,"5.30671","1.0136","sp|Q68D91|MBLC2_HUMAN","sp|Q68D91|MBLC2_HUMAN",2933,"Q68D91","MBLC2_HUMAN","Metallo-beta-lactamase domain-containing protein 2",null,"MBLAC2"]
["18.5861","16.9034","17.8478","18.7496","17.668",1,{"$nulls":3},"cell surface receptor signaling pathway;phosphatidylinositol biosynthetic process;phospholipid metabolic process;positive regulation of autophagosome assembly;regulation of autophagy;regulation of phosphatidylinositol 3-kinase signaling","1-phosphatidylinositol-3-phosphate 4-kinase activity;1-phosphatidylinositol-4-phosphate 5-kinase activity;1-phosphatidylinositol-5-phosphate 4-kinase activity;ATP binding;protein homodimerization activity;signal transducer activity, downstream of receptor","autophagosome;cytosol;endoplasmic reticulum membrane;nucleoplasm;plasma membrane","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Regulation of actin cytoskeleton",null,null,9,5,5,"24.8","14.7","14.7","47.377",0,"36.887",368700000,38,"0.38781",1,"5.30655","0.920419","sp|P78356|PI42B_HUMAN;tr|A0A087WT35|A0A087WT35_HUMAN","sp|P78356|PI42B_HUMAN",2059,"P78356","PI42B_HUMAN","Phosphatidylinositol 5-phosphate 4-kinase type-2 beta",null,"PIP4K2B"]
["16.7606","17.7531","17.621","18.401","16.8282",1,{"$nulls":5},"nucleus",{"$nulls":3},4,4,4,"14.2","14.2","14.2","41.918",0,"30.789",174690000,13,"0.403703",1,"5.3018","0.95262","tr|B0QXZ6|B0QXZ6_HUMAN;sp|O95503|CBX6_HUMAN","tr|B0QXZ6|B0QXZ6_HUMAN;sp|O95503|CBX6_HUMAN",765,"B0QXZ6","B0QXZ6_HUMAN",null,null,"CBX6"]
["16.317",1,"15.8298",1,1,"15.2815",{"$nulls":3},"glycosaminoglycan biosynthetic process;O-glycan processing","carbohydrate binding;metal ion binding;polypeptide N-acetylgalactosaminyltransferase activity","Golgi membrane;integral component of membrane","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,1,1,1,"1.5","1.5","1.5","106.26","0.0050195","2.4959",17253000,0,"0.312023",1,"5.28841","0.763893","sp|Q7Z7M9|GALT5_HUMAN","sp|Q7Z7M9|GALT5_HUMAN",3200,"Q7Z7M9","GALT5_HUMAN","Polypeptide N-acetylgalactosaminyltransferase 5",null,"GALNT5"]
["18.906","17.5937","17.9424","20.3515","17.2541",1,{"$nulls":3},"DNA repair","DNA 5'-adenosine monophosphate hydrolase activity;DNA binding",{"$nulls":4},2,2,2,"12.1","12.1","12.1","22.763",0,"5.5323",50554000,5,"0.366893",1,"5.27881","0.877743","tr|F8W6G5|F8W6G5_HUMAN;tr|A0A0A0MRW7|A0A0A0MRW7_HUMAN;sp|Q7Z2E3|APTX_HUMAN;tr|C9J8U3|C9J8U3_HUMAN;tr|C9JZ40|C9JZ40_HUMAN","tr|F8W6G5|F8W6G5_HUMAN;tr|A0A0A0MRW7|A0A0A0MRW7_HUMAN;sp|Q7Z2E3|APTX_HUMAN;tr|C9J8U3|C9J8U3_HUMAN;tr|C9JZ40|C9JZ40_HUMAN",3142,"F8W6G5","F8W6G5_HUMAN",null,null,"APTX"]
["13.6093","15.3644","15.8445","12.6149","15.3693",1,{"$nulls":3},"cell adhesion;cell-cell junction assembly;cytoskeletal anchoring at plasma membrane","actin binding;actin filament binding;structural constituent of cytoskeleton;structural molecule activity","actin cytoskeleton;cell-cell junction;cytoplasm;focal adhesion;plasma membrane;ruffle;synapse","Focal adhesion;Human T-cell leukemia virus 1 infection;Platelet activation;Rap1 signaling pathway",null,null,10,3,3,"4.1",1,1,"271.61","0.0019249","3.0451",62659000,8,"0.520389",1,"5.27796","1.18468","sp|Q9Y4G6|TLN2_HUMAN;tr|H0YMT1|H0YMT1_HUMAN;tr|H0YN01|H0YN01_HUMAN","sp|Q9Y4G6|TLN2_HUMAN;tr|H0YMT1|H0YMT1_HUMAN",5327,"Q9Y4G6","TLN2_HUMAN","Talin-2",null,"TLN2"]
["17.9847",1,"17.6333","18.8078",1,1,{"$nulls":3},"intracellular distribution of mitochondria",null,"cytoplasm",{"$nulls":3},30,2,2,"35.4",3,3,"138.23","0.00021505","5.0322",92018000,6,"0.256712",1,"5.27006","0.645581","tr|I3L2B0|I3L2B0_HUMAN","tr|I3L2B0|I3L2B0_HUMAN",5582,"I3L2B0","I3L2B0_HUMAN",null,null,"CLUH"]
[1,"15.9223","16.231",1,1,"15.3449",{"$nulls":3},"angiogenesis;cell adhesion;positive regulation of angiogenesis;positive regulation of endothelial cell proliferation;vasculogenesis","nucleic acid binding","cytoplasm;extracellular region;perinuclear region of cytoplasm",{"$nulls":3},1,1,1,"1.8","1.8","1.8","80.976",0,"9.3647",8118500,3,"0.309966",1,"5.26944","0.759565","sp|Q8N302|AGGF1_HUMAN","sp|Q8N302|AGGF1_HUMAN",3385,"Q8N302","AGGF1_HUMAN","Angiogenic factor with G patch and FHA domains 1",null,"AGGF1"]
["17.8145","16.8094","18.4906","19.5466","16.7606",1,{"$nulls":5},"endoplasmic reticulum;Golgi apparatus",{"$nulls":3},4,4,4,"24.1","24.1","24.1","33.874",0,"8.3997",46590000,6,"0.382337",1,"5.26911","0.909287","tr|R4GNG2|R4GNG2_HUMAN;sp|Q9UKV5|AMFR_HUMAN;tr|H3BRK9|H3BRK9_HUMAN","tr|R4GNG2|R4GNG2_HUMAN;sp|Q9UKV5|AMFR_HUMAN;tr|H3BRK9|H3BRK9_HUMAN",5100,"R4GNG2","R4GNG2_HUMAN",null,null,"AMFR"]
["15.7605","13.9944",1,1,"13.0118",1,{"$nulls":3},"motor neuron migration",null,"membrane",{"$nulls":3},2,2,2,"2.7","2.7","2.7","170.67",0,"5.5589",13109000,2,"0.355718",1,"5.24773","0.854793","sp|Q5SYE7|NHSL1_HUMAN","sp|Q5SYE7|NHSL1_HUMAN",2856,"Q5SYE7","NHSL1_HUMAN","NHS-like protein 1",null,"NHSL1"]
["16.1631","17.276","15.407","15.7072","16.4092",1,{"$nulls":9},2,2,2,"2.8","2.8","2.8","106.01",0,"5.926",34288000,5,"0.446093",1,"5.24323","1.0377","tr|A0A0A0MTP7|A0A0A0MTP7_HUMAN;tr|F8VXG7|F8VXG7_HUMAN;sp|Q99590|SCAFB_HUMAN","tr|A0A0A0MTP7|A0A0A0MTP7_HUMAN;tr|F8VXG7|F8VXG7_HUMAN;sp|Q99590|SCAFB_HUMAN",4084,"A0A0A0MTP7","A0A0A0MTP7_HUMAN",null,null,"SCAF11"]
["15.5535","13.8098",1,1,"12.6599",1,{"$nulls":3},"carbohydrate metabolic process;cellular protein modification process;glycosaminoglycan biosynthetic process;glycosaminoglycan metabolic process;negative regulation of fibroblast proliferation;protein N-linked glycosylation;proteoglycan metabolic process;supramolecular fiber organization","beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;galactosyltransferase activity;manganese ion binding;xylosylprotein 4-beta-galactosyltransferase activity","Golgi apparatus;Golgi cisterna membrane;Golgi membrane;integral component of membrane","Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate;Glycosaminoglycan biosynthesis - heparan sulfate / heparin;Metabolic pathways",null,null,2,2,2,"7.6","7.6","7.6","37.405","0.00042608","4.7974",8052500,3,"0.36336",1,"5.23444","0.870499","sp|Q9UBV7|B4GT7_HUMAN;tr|H0Y9D6|H0Y9D6_HUMAN;tr|D6RJI5|D6RJI5_HUMAN","sp|Q9UBV7|B4GT7_HUMAN;tr|H0Y9D6|H0Y9D6_HUMAN;tr|D6RJI5|D6RJI5_HUMAN",4979,"Q9UBV7","B4GT7_HUMAN","Beta-1,4-galactosyltransferase 7","4Gal-T7;eta-1,4-GalTase 7;eta4Gal-T7","B4GALT7"]
["16.2356","16.7348","16.2947",1,"15.9728","16.634",{"$nulls":3},"cytoplasmic sequestering of transcription factor;double-strand break repair via homologous recombination;replication fork processing","histone binding;transcription corepressor activity","cytoplasm;nuclear body;nuclear replication fork;nucleoplasm",{"$nulls":3},2,2,2,"1.7","1.7","1.7","150.93","0.00042159","4.5909",61404000,11,"0.438225",1,"5.21942","1.02199","sp|Q96HA7|TONSL_HUMAN;tr|A0A087X1F6|A0A087X1F6_HUMAN","sp|Q96HA7|TONSL_HUMAN;tr|A0A087X1F6|A0A087X1F6_HUMAN",3908,"Q96HA7","TONSL_HUMAN","Tonsoku-like protein",null,"TONSL"]
["17.3834","17.3765","19.2919",1,"18.2656","19.1743",{"$nulls":3},"animal organ regeneration;cell cycle G1/S phase transition;cell division;cellular response to cocaine;cellular response to estradiol stimulus;cellular response to hypoxia;cellular response to insulin-like growth factor stimulus;cellular response to leptin stimulus;cellular response to luteinizing hormone stimulus;cellular response to nitric oxide;cellular response to platelet-derived growth factor stimulus;cochlea development;G2/M transition of mitotic cell cycle;histone phosphorylation;positive regulation of fibroblast proliferation;positive regulation of transcription, DNA-templated;protein deubiquitination;Ras protein signal transduction;regulation of cell cycle;response to glucagon;viral process","protein domain specific binding;protein kinase binding","cyclin A2-CDK2 complex;cyclin-dependent protein kinase holoenzyme complex;cytoplasm;cytosol;female pronucleus;male pronucleus;nucleoplasm;nucleus","AMPK signaling pathway;Cell cycle;Cellular senescence;Epstein-Barr virus infection;Hepatitis B;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Progesterone-mediated oocyte maturation;Viral carcinogenesis",null,null,2,2,2,9,9,9,"48.55","0.0053773","2.4535",72688000,4,"0.365602",1,"5.20396","0.875097","sp|P20248|CCNA2_HUMAN;sp|P78396|CCNA1_HUMAN","sp|P20248|CCNA2_HUMAN;sp|P78396|CCNA1_HUMAN",1206,"P20248","CCNA2_HUMAN","Cyclin-A2 {ECO:0000312|HGNC:HGNC:1578}","yclin-A {ECO:0000303|PubMed:1967822}","CCNA2"]
["16.7918",1,"16.8284",1,1,"17.0413",{"$nulls":5},"cytosol",{"$nulls":3},1,1,1,"2.1","2.1","2.1","68.456","0.0013576","3.1717",13091000,1,"0.278037",1,"5.19296","0.691688","tr|E9PD99|E9PD99_HUMAN;sp|Q96II8|LRCH3_HUMAN","tr|E9PD99|E9PD99_HUMAN;sp|Q96II8|LRCH3_HUMAN",3927,"E9PD99","E9PD99_HUMAN",null,null,"LRCH3"]
["16.4388","16.1401","17.0798",1,"16.1009","16.9904",{"$nulls":4},"flavin adenine dinucleotide binding;tRNA dihydrouridine synthase activity","cytosol",{"$nulls":3},2,2,2,7,7,7,"51.388","0.00041623","4.2901",23033000,4,"0.426621",1,"5.18915","0.998751","tr|E7EUN9|E7EUN9_HUMAN;sp|Q9NX74|DUS2L_HUMAN","tr|E7EUN9|E7EUN9_HUMAN;sp|Q9NX74|DUS2L_HUMAN",4819,"E7EUN9","E7EUN9_HUMAN",null,null,"DUS2"]
["16.4194",1,"16.0157",1,1,"15.9524",{"$nulls":9},2,2,2,"1.2","1.2","1.2","237.3","0.0024933","3.0025",147900000,11,"0.293925",1,"5.1609","0.725626","sp|Q5THK1|PR14L_HUMAN;tr|C9J9V0|C9J9V0_HUMAN;tr|H7BZH1|H7BZH1_HUMAN","sp|Q5THK1|PR14L_HUMAN;tr|C9J9V0|C9J9V0_HUMAN;tr|H7BZH1|H7BZH1_HUMAN",2889,"Q5THK1","PR14L_HUMAN","Protein PRR14L",null,"PRR14L"]
["16.609","16.4296","17.3181",1,"16.7909","17.0925",{"$nulls":3},"dolichol-linked oligosaccharide biosynthetic process;protein glycosylation","chitobiosyldiphosphodolichol beta-mannosyltransferase activity;mannosyltransferase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane","Metabolic pathways;N-Glycan biosynthesis",null,null,4,4,4,"11.2","11.2","11.2","52.518",0,"5.7183",20377000,3,"0.411933",1,"5.15777","0.969226","sp|Q9BT22|ALG1_HUMAN;tr|K7EID2|K7EID2_HUMAN;tr|K7EPU3|K7EPU3_HUMAN","sp|Q9BT22|ALG1_HUMAN;tr|K7EID2|K7EID2_HUMAN",4194,"Q9BT22","ALG1_HUMAN","Chitobiosyldiphosphodolichol beta-mannosyltransferase",null,"ALG1"]
["19.8919","15.8026",1,"19.2466",1,1,{"$nulls":5},"cytosol;extracellular exosome;Golgi apparatus;nucleoplasm",{"$nulls":3},4,4,4,"18.2","18.2","18.2","39.933",0,"14.396",24226000,5,"0.243104",1,"5.1493","0.615797","sp|Q96A49|SYAP1_HUMAN","sp|Q96A49|SYAP1_HUMAN",3780,"Q96A49","SYAP1_HUMAN","Synapse-associated protein 1",null,"SYAP1"]
["16.7263","14.7036","16.1521",1,"14.0544","17.1055",{"$nulls":3},"positive regulation of rRNA processing;positive regulation of transcription from RNA polymerase I promoter;rRNA processing;transcription, DNA-templated","RNA binding","cytoplasm;endoplasmic reticulum;fibrillar center;nucleolus;nucleoplasm","Ribosome biogenesis in eukaryotes",null,null,9,9,9,"27.6","27.6","27.6","58.414",0,"33.297",111700000,16,"0.443818",1,"5.14067","1.03316","sp|Q8TED0|UTP15_HUMAN;tr|H0Y8P4|H0Y8P4_HUMAN;tr|D6RF65|D6RF65_HUMAN","sp|Q8TED0|UTP15_HUMAN;tr|H0Y8P4|H0Y8P4_HUMAN",3576,"Q8TED0","UTP15_HUMAN","U3 small nucleolar RNA-associated protein 15 homolog",null,"UTP15"]
["19.2387","15.9968","18.5265",1,"17.4652","19.9063",{"$nulls":3},"cellular protein modification process;cellular response to starvation;nucleocytoplasmic transport;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;post-translational protein modification;protein polyubiquitination;regulation of skeletal muscle fiber development;ubiquitin-dependent protein catabolic process","ubiquitin-protein transferase activity","cytosol;nucleus;Z disc",{"$nulls":3},6,6,6,"25.1","25.1","25.1","44.508",0,"36.158",144400000,12,"0.354578",1,"5.13014","0.852446","sp|Q8NEZ5|FBX22_HUMAN;tr|H3BTH6|H3BTH6_HUMAN;tr|H3BVA4|H3BVA4_HUMAN;tr|H3BUC1|H3BUC1_HUMAN;tr|H3BTR7|H3BTR7_HUMAN;tr|H3BRE0|H3BRE0_HUMAN","sp|Q8NEZ5|FBX22_HUMAN;tr|H3BTH6|H3BTH6_HUMAN;tr|H3BVA4|H3BVA4_HUMAN",3498,"Q8NEZ5","FBX22_HUMAN","F-box only protein 22",null,"FBXO22"]
[1,"17.1435","16.1275",1,"16.928",1,{"$nulls":4},"metal ion binding",{"$nulls":4},3,3,3,"7.8","7.8","7.8","49.203","0.0084157","2.2727",15501000,2,"0.275802",1,"5.11435","0.686888","tr|H3BRF9|H3BRF9_HUMAN;sp|Q96K21|ANCHR_HUMAN;tr|H3BN64|H3BN64_HUMAN;tr|H3BRM1|H3BRM1_HUMAN;tr|H3BUW6|H3BUW6_HUMAN","tr|H3BRF9|H3BRF9_HUMAN;sp|Q96K21|ANCHR_HUMAN;tr|H3BN64|H3BN64_HUMAN;tr|H3BRM1|H3BRM1_HUMAN",3951,"H3BRF9","H3BRF9_HUMAN",null,null,"ZFYVE19"]
["17.1291",1,"16.1286",1,"16.9187",1,{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},6,6,6,"11.1","11.1","11.1","102.13",0,"23.214",94310000,14,"0.275887",1,"5.11299","0.687069","tr|A0A087WWP4|A0A087WWP4_HUMAN;sp|Q96T37|RBM15_HUMAN","tr|A0A087WWP4|A0A087WWP4_HUMAN;sp|Q96T37|RBM15_HUMAN",4050,"A0A087WWP4","A0A087WWP4_HUMAN",null,null,"RBM15"]
["16.2985","16.8687","16.4083","17.2539","16.01",1,{"$nulls":4},"heme binding;iron ion binding;monooxygenase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen","integral component of membrane;membrane",{"$nulls":3},2,2,2,"6.1","6.1","6.1","52.432","0.0011772","3.275",23654000,4,"0.415623",1,"5.10392","0.976655","sp|Q6UW02|CP20A_HUMAN;tr|E9PHG5|E9PHG5_HUMAN;tr|Q8WZ13|Q8WZ13_HUMAN;tr|F8WBE2|F8WBE2_HUMAN;tr|C9J8K7|C9J8K7_HUMAN","sp|Q6UW02|CP20A_HUMAN;tr|E9PHG5|E9PHG5_HUMAN;tr|Q8WZ13|Q8WZ13_HUMAN;tr|F8WBE2|F8WBE2_HUMAN;tr|C9J8K7|C9J8K7_HUMAN",3055,"Q6UW02","CP20A_HUMAN","Cytochrome P450 20A1",null,"CYP20A1"]
["15.5751","15.7236",1,1,"15.0115",1,{"$nulls":9},14,2,2,"13.4","2.4","2.4","142.58",0,"6.9127",48668000,8,"0.307378",1,"5.0957","0.75411","tr|E7EVJ5|E7EVJ5_HUMAN;sp|Q96F07|CYFP2_HUMAN;tr|H7C229|H7C229_HUMAN;tr|E7EW33|E7EW33_HUMAN;tr|A0A087WVE1|A0A087WVE1_HUMAN;tr|A0A087WTQ3|A0A087WTQ3_HUMAN;tr|A0A087WWZ1|A0A087WWZ1_HUMAN;tr|A0A087X0D6|A0A087X0D6_HUMAN;tr|A0A087WV63|A0A087WV63_HUMAN;tr|A0A0G2JRF5|A0A0G2JRF5_HUMAN;tr|A0A087WWY5|A0A087WWY5_HUMAN;tr|A0A087WZL7|A0A087WZL7_HUMAN","tr|E7EVJ5|E7EVJ5_HUMAN;sp|Q96F07|CYFP2_HUMAN;tr|H7C229|H7C229_HUMAN;tr|E7EW33|E7EW33_HUMAN",5507,"E7EVJ5","E7EVJ5_HUMAN",null,null,"CYFIP2"]
["16.5687","15.6791",1,"15.9743",1,1,{"$nulls":3},"cellular metabolic process",{"$nulls":5},19,1,1,"47.3","3.8","3.8","57.495",0,"6.5318",39093000,10,"0.289953",1,"5.09117","0.717173","tr|A0A087WTA5|A0A087WTA5_HUMAN","tr|A0A087WTA5|A0A087WTA5_HUMAN",5431,"A0A087WTA5","A0A087WTA5_HUMAN",null,null,"EIF2B4"]
["14.6018","12.9388","14.1171",1,"12.1467","13.2802",{"$nulls":3},"innate immune response;negative regulation of gene expression;negative regulation of interferon-gamma-mediated signaling pathway;negative regulation of tyrosine phosphorylation of STAT protein;positive regulation of interleukin-4-mediated signaling pathway;positive regulation of tyrosine phosphorylation of STAT protein;protein ADP-ribosylation;protein poly-ADP-ribosylation;regulation of transcription, DNA-templated;transcription, DNA-templated","enzyme binding;NAD+ ADP-ribosyltransferase activity;NAD+ binding;RNA binding","cytoplasm;cytosol;membrane;nucleus",{"$nulls":3},5,5,5,"4.1","4.1","4.1","202.8",0,"9.486",35352000,7,"0.571905",1,"5.0769","1.28556","sp|Q460N5|PAR14_HUMAN;tr|H7C5R8|H7C5R8_HUMAN","sp|Q460N5|PAR14_HUMAN;tr|H7C5R8|H7C5R8_HUMAN",2747,"Q460N5","PAR14_HUMAN","Poly [ADP-ribose] polymerase 14","ARP-14","PARP14"]
["16.5762","17.4306","16.6887",1,"18.9124","15.5796",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA processing","RNA binding","nuclear membrane;nucleolus;nucleoplasm;nucleus;Pwp2p-containing subcomplex of 90S preribosome;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,11,11,11,"29.9","29.9","29.9","62.003",0,"93.49",629410000,56,"0.387758",1,"5.06785","0.920314","sp|Q9Y5J1|UTP18_HUMAN;tr|J3KSR7|J3KSR7_HUMAN;tr|J3QRG0|J3QRG0_HUMAN;tr|J3QR85|J3QR85_HUMAN;tr|J3QLD6|J3QLD6_HUMAN","sp|Q9Y5J1|UTP18_HUMAN",5353,"Q9Y5J1","UTP18_HUMAN","U3 small nucleolar RNA-associated protein 18 homolog",null,"UTP18"]
["18.8559","16.6552","19.3535","19.1826",1,"19.5248",{"$nulls":3},"apoptotic process;L-methionine salvage from methylthioadenosine;negative regulation of apoptotic process;protein homotetramerization;pyroptosis;regulation of ERK1 and ERK2 cascade","identical protein binding;methylthioribulose 1-phosphate dehydratase activity;zinc ion binding","cytoplasm","Cysteine and methionine metabolism;Metabolic pathways",null,null,4,4,4,"25.2","25.2","25.2","27.125",0,"16.583",57882000,13,"0.338041",1,"5.05241","0.818255","sp|Q96GX9|MTNB_HUMAN;tr|S4R3D6|S4R3D6_HUMAN","sp|Q96GX9|MTNB_HUMAN;tr|S4R3D6|S4R3D6_HUMAN",3903,"Q96GX9","MTNB_HUMAN","Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}","TRu-1-P dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}","APIP"]
["17.4651","15.9237",1,1,"17.2755",1,{"$nulls":3},"cytokinesis;microtubule bundle formation;mitotic spindle elongation;positive regulation of cell proliferation","identical protein binding;kinesin binding;microtubule binding;protein kinase binding","contractile ring;cytosol;microtubule cytoskeleton;midbody;nucleoplasm;nucleus;plasma membrane;spindle;spindle microtubule;spindle pole",{"$nulls":3},14,14,14,"30.5","30.5","30.5","71.606",0,"36.662",226390000,37,"0.266707",1,"5.03775","0.667275","sp|O43663|PRC1_HUMAN;tr|H0YL53|H0YL53_HUMAN;tr|G3V3N7|G3V3N7_HUMAN;tr|H0YM42|H0YM42_HUMAN;tr|H0YNE4|H0YNE4_HUMAN;tr|H0YLA0|H0YLA0_HUMAN","sp|O43663|PRC1_HUMAN",438,"O43663","PRC1_HUMAN","Protein regulator of cytokinesis 1 {ECO:0000312|HGNC:HGNC:9341}",null,"PRC1"]
[1,"15.1291","15.6433",1,"14.6907",1,{"$nulls":3},"cell motility;cytoskeleton organization;Fc-gamma receptor signaling pathway involved in phagocytosis;inositol lipid-mediated signaling;lipid catabolic process;phosphatidic acid biosynthetic process;small GTPase mediated signal transduction;synaptic vesicle recycling","N-acylphosphatidylethanolamine-specific phospholipase D activity;phosphatidylinositol binding;phospholipase D activity","endoplasmic reticulum membrane;Golgi apparatus;plasma membrane;presynapse","cAMP signaling pathway;Choline metabolism in cancer;Endocytosis;Ether lipid metabolism;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;Glycerophospholipid metabolism;GnRH signaling pathway;Metabolic pathways;Parathyroid hormone synthesis, secretion and action;Phospholipase D signaling pathway;Ras signaling pathway;Sphingolipid signaling pathway",null,null,5,5,5,"7.7","7.7","7.7","105.99",0,"14.038",43432000,12,"0.309809",1,"5.02724","0.759233","sp|O14939|PLD2_HUMAN;tr|I3L1F3|I3L1F3_HUMAN;tr|I3L222|I3L222_HUMAN","sp|O14939|PLD2_HUMAN",312,"O14939","PLD2_HUMAN","Phospholipase D2","LD 2;PLD2","PLD2"]
["17.4794","17.4789","20.2357","18.8442",1,"20.2908",{"$nulls":3},"apoptotic process;positive regulation of cell death;regulation of transcription, DNA-templated;transcription, DNA-templated",null,"intermediate filament cytoskeleton;nucleoplasm;nucleus",{"$nulls":3},9,9,9,"41.2","41.2","41.2","33.87",0,"26.933",379150000,38,"0.32949",1,"5.01967","0.800468","sp|Q9UHR5|S30BP_HUMAN;tr|J3QQJ0|J3QQJ0_HUMAN;tr|X6R3T8|X6R3T8_HUMAN;tr|J3QLH3|J3QLH3_HUMAN;tr|F5H478|F5H478_HUMAN;tr|J3KRU5|J3KRU5_HUMAN;tr|J3KS14|J3KS14_HUMAN;tr|J3QLM2|J3QLM2_HUMAN;tr|J3KRR6|J3KRR6_HUMAN","sp|Q9UHR5|S30BP_HUMAN;tr|J3QQJ0|J3QQJ0_HUMAN;tr|X6R3T8|X6R3T8_HUMAN;tr|J3QLH3|J3QLH3_HUMAN;tr|F5H478|F5H478_HUMAN;tr|J3KRU5|J3KRU5_HUMAN",5032,"Q9UHR5","S30BP_HUMAN","SAP30-binding protein",null,"SAP30BP"]
[1,"14.5097","15.6733","14.1285",1,1,{"$nulls":3},"histone exchange;nucleosome assembly;regulation of chromatin assembly;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;histone binding;RNA polymerase I core binding","nucleolus",{"$nulls":3},4,4,4,"9.8","9.8","9.8","75.598",0,"9.8524",73000000,13,"0.319981",1,"5.01816","0.7806","sp|Q68D10|SPT2_HUMAN","sp|Q68D10|SPT2_HUMAN",2932,"Q68D10","SPT2_HUMAN","Protein SPT2 homolog",null,"SPTY2D1"]
["13.6148","15.9292","17.1153","13.9239",1,"16.6987",{"$nulls":3},"activation of GTPase activity;regulation of small GTPase mediated signal transduction","GTPase activator activity;protein heterodimerization activity","cytoplasm;nucleus",{"$nulls":3},7,7,7,"3.7","3.7","3.7","229.83",0,"9.448",70778000,8,"0.434008",1,"5.01223","1.01355","sp|Q6GYQ0|RGPA1_HUMAN;tr|H0YJB5|H0YJB5_HUMAN;tr|H0YJ04|H0YJ04_HUMAN","sp|Q6GYQ0|RGPA1_HUMAN",2955,"Q6GYQ0","RGPA1_HUMAN","Ral GTPase-activating protein subunit alpha-1",null,"RALGAPA1"]
["16.0348","14.7289","14.3297","13.3485",1,"15.7582",{"$nulls":3},"DNA metabolic process","actin filament binding;ATP binding;DNA binding;DNA-dependent ATPase activity;motor activity","myosin complex",{"$nulls":3},8,8,8,"6.1","6.1","6.1","231.1",0,"19.493",44914000,9,"0.470385",1,"4.99555","1.08601","tr|A0A0D9SFK2|A0A0D9SFK2_HUMAN;sp|Q92614|MY18A_HUMAN;tr|H0YEV9|H0YEV9_HUMAN","tr|A0A0D9SFK2|A0A0D9SFK2_HUMAN;sp|Q92614|MY18A_HUMAN",3691,"A0A0D9SFK2","A0A0D9SFK2_HUMAN",null,null,"MYO18A"]
["15.9878","15.7749","16.4724",1,"16.31","15.9448",{"$nulls":3},"intracellular signal transduction","ATP binding;metal ion binding;protein serine/threonine kinase activity;signal transducer activity, downstream of receptor","intracellular",{"$nulls":3},5,5,2,"13.3","13.3","6.8","59.741",0,"12.722",75769000,14,"0.421878",1,"4.99344","0.989232","tr|H7C155|H7C155_HUMAN;sp|P04049|RAF1_HUMAN;tr|H7C4S5|H7C4S5_HUMAN","tr|H7C155|H7C155_HUMAN;sp|P04049|RAF1_HUMAN",861,"H7C155","H7C155_HUMAN",null,null,"RAF1"]
["16.1425","16.0407","16.8543",1,"15.8562","17.2013",{"$nulls":3},"mitochondrial threonyl-tRNA aminoacylation","aminoacyl-tRNA editing activity;ATP binding;protein homodimerization activity;threonine-tRNA ligase activity","mitochondrial matrix;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,5,5,5,"11.7","11.7","11.7","81.035",0,"6.7131",29203000,7,"0.407754",1,"4.99336","0.960799","sp|Q9BW92|SYTM_HUMAN;tr|U3KQG0|U3KQG0_HUMAN;tr|F6S7Q7|F6S7Q7_HUMAN;tr|Q5T5E9|Q5T5E9_HUMAN;tr|U3KQ50|U3KQ50_HUMAN","sp|Q9BW92|SYTM_HUMAN;tr|U3KQG0|U3KQG0_HUMAN;tr|F6S7Q7|F6S7Q7_HUMAN",4276,"Q9BW92","SYTM_HUMAN","Threonine--tRNA ligase, mitochondrial",null,"TARS2"]
["16.9893","15.6322",1,1,"16.6441",1,{"$nulls":3},"maturation of 5.8S rRNA;maturation of LSU-rRNA",null,"PeBoW complex;preribosome, large subunit precursor",{"$nulls":3},8,8,8,"22.5","22.5","22.5","54.665",0,"52.791",156960000,20,"0.274104",1,"4.99244","0.683235","sp|Q9Y2I8|WDR37_HUMAN;tr|C9JGR9|C9JGR9_HUMAN;tr|E7EQ49|E7EQ49_HUMAN;tr|A0A087WTQ2|A0A087WTQ2_HUMAN","sp|Q9Y2I8|WDR37_HUMAN;tr|C9JGR9|C9JGR9_HUMAN;tr|E7EQ49|E7EQ49_HUMAN;tr|A0A087WTQ2|A0A087WTQ2_HUMAN",5225,"Q9Y2I8","WDR37_HUMAN","WD repeat-containing protein 37",null,"WDR37"]
["14.9679","13.6054",1,1,"12.6598",1,{"$nulls":9},3,2,2,"3.2","2.5","2.5","146.68",0,"6.3562",15678000,4,"0.349407",1,"4.97117","0.841783","tr|E9PFH7|E9PFH7_HUMAN;sp|Q9UPT6|JIP3_HUMAN;tr|A0A087WYG2|A0A087WYG2_HUMAN","tr|E9PFH7|E9PFH7_HUMAN;sp|Q9UPT6|JIP3_HUMAN;tr|A0A087WYG2|A0A087WYG2_HUMAN",5179,"E9PFH7","E9PFH7_HUMAN",null,null,"MAPK8IP3"]
["16.6981","15.5712","17.8604","18.4609","15.8103",1,{"$nulls":3},"mRNA 3'-end processing;mRNA splicing, via spliceosome;pre-mRNA cleavage required for polyadenylation;termination of RNA polymerase II transcription","mRNA binding;RNA binding","intracellular;mRNA cleavage and polyadenylation specificity factor complex;nucleoplasm","mRNA surveillance pathway",null,null,3,3,3,"9.6","9.6","9.6","64.436","0.0024947","3.0077",32031000,3,"0.380231",1,"4.95282","0.904998","sp|Q9H0L4|CSTFT_HUMAN;tr|E9PID8|E9PID8_HUMAN;sp|P33240|CSTF2_HUMAN;tr|E7EWR4|E7EWR4_HUMAN","sp|Q9H0L4|CSTFT_HUMAN;tr|E9PID8|E9PID8_HUMAN;sp|P33240|CSTF2_HUMAN;tr|E7EWR4|E7EWR4_HUMAN",4392,"Q9H0L4","CSTFT_HUMAN","Cleavage stimulation factor subunit 2 tau variant",null,"CSTF2T"]
["18.6212","16.6043","18.3676","18.806",1,"18.9417",{"$nulls":3},"apoptotic process;defense response to virus;inflammatory response;innate immune response;negative regulation of alpha-beta T cell proliferation;negative regulation of apoptotic process;negative regulation of defense response to virus;negative regulation of JNK cascade;negative regulation of NF-kappaB transcription factor activity;negative regulation of type I interferon production;Notch signaling pathway;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of protein catabolic process;positive regulation of receptor catabolic process;positive regulation of T cell anergy;proteasome-mediated ubiquitin-dependent protein catabolic process;protein autoubiquitination;protein K29-linked ubiquitination;protein K48-linked ubiquitination;protein K63-linked ubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of cell growth;regulation of hematopoietic stem cell differentiation;regulation of protein deubiquitination;ubiquitin-dependent protein catabolic process;viral entry into host cell","arrestin family protein binding;CXCR chemokine receptor binding;ligase activity;ribonucleoprotein complex binding;ubiquitin protein ligase activity;ubiquitin-like protein ligase binding;ubiquitin-like protein transferase activity;ubiquitin-protein transferase activity","cell cortex;cytoplasm;cytosol;early endosome membrane;extracellular exosome;membrane;nucleoplasm;plasma membrane;protein complex","Endocytosis;Non-alcoholic fatty liver disease (NAFLD);TNF signaling pathway;Ubiquitin mediated proteolysis",null,null,8,8,8,"10.6","10.6","10.6","102.8",0,"20.479",130890000,12,"0.341721",1,"4.94849","0.825887","sp|Q96J02|ITCH_HUMAN","sp|Q96J02|ITCH_HUMAN",3934,"Q96J02","ITCH_HUMAN","E3 ubiquitin-protein ligase Itchy homolog","tch","ITCH"]
["16.2883","13.782","17.1994","15.5819","15.8501",1,{"$nulls":3},"covalent chromatin modification;erythrocyte maturation;granulocyte differentiation;macrophage differentiation;transcription, DNA-templated","DNA binding transcription factor activity;zinc ion binding","nucleolus;nucleus",{"$nulls":3},5,5,5,"8.7","8.7","8.7","88.336",0,"39.709",115160000,16,"0.420747",1,"4.94587","0.986959","sp|Q96JM7|LMBL3_HUMAN;tr|E9PLL7|E9PLL7_HUMAN","sp|Q96JM7|LMBL3_HUMAN",3943,"Q96JM7","LMBL3_HUMAN","Lethal(3)malignant brain tumor-like protein 3","(3)mbt-like protein 3;-l(3)mbt-like protein 3","L3MBTL3"]
["16.4515","15.1871","14.8548","16.2685","14.4152",1,{"$nulls":3},"cytoskeleton organization;negative regulation of apoptotic process;regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity","cytosol;perinuclear region of cytoplasm;plasma membrane","Bacterial invasion of epithelial cells",null,null,10,10,10,"17.4","17.4","17.4","89.374",0,"20.491",227810000,22,"0.437738",1,"4.93658","1.02101","sp|A1A4S6|RHG10_HUMAN;tr|H0Y8W5|H0Y8W5_HUMAN","sp|A1A4S6|RHG10_HUMAN",169,"A1A4S6","RHG10_HUMAN","Rho GTPase-activating protein 10",null,"ARHGAP10"]
["16.0465","15.151","16.3327",1,"15.0591","16.6707",{"$nulls":3},"isoprenoid biosynthetic process;protein heterotetramerization;regulation of body fluid levels;ubiquinone biosynthetic process","protein heterodimerization activity;trans-hexaprenyltranstransferase activity;trans-octaprenyltranstransferase activity","cytosol;mitochondrial matrix;transferase complex","Terpenoid backbone biosynthesis",null,null,2,2,2,7,7,7,"44.128","0.00021603","5.1107",13474000,3,"0.421651",1,"4.93347","0.988776","sp|Q86YH6|DLP1_HUMAN","sp|Q86YH6|DLP1_HUMAN",3269,"Q86YH6","DLP1_HUMAN","Decaprenyl-diphosphate synthase subunit 2",null,"PDSS2"]
["16.5442","15.9782","16.359","17.5312",1,"15.5602",{"$nulls":9},2,2,2,"5.1","5.1","5.1","63.512","0.0011969","3.527",28588000,3,"0.40005",1,"4.93005","0.945234","tr|A8DPD7|A8DPD7_HUMAN;sp|Q9C0D3|ZY11B_HUMAN","tr|A8DPD7|A8DPD7_HUMAN;sp|Q9C0D3|ZY11B_HUMAN",4351,"A8DPD7","A8DPD7_HUMAN"]
["17.0684","16.1931","18.463",1,"16.7993","19.156",{"$nulls":3},"endosome to lysosome transport via multivesicular body sorting pathway;ERAD pathway;macroautophagy",null,"cytoplasm;cytosol;early endosome membrane;extracellular exosome;extrinsic component of membrane;late endosome membrane;lysosomal membrane;microtubule organizing center;nucleus;protein complex","Protein processing in endoplasmic reticulum",null,null,6,6,6,24,24,24,"49.753",0,"31.747",94051000,11,"0.357257",1,"4.92311","0.857961","sp|Q9BZV1|UBXN6_HUMAN;tr|K7EP32|K7EP32_HUMAN","sp|Q9BZV1|UBXN6_HUMAN;tr|K7EP32|K7EP32_HUMAN",4341,"Q9BZV1","UBXN6_HUMAN","UBX domain-containing protein 6 {ECO:0000305}",null,"UBXN6"]
["24.002","15.3692","20.4567","23.7557",1,"20.3079",{"$nulls":3},"regulation of translational initiation","ribosome binding;translation initiation factor activity","eukaryotic translation initiation factor 3 complex",{"$nulls":3},4,4,4,"31.4","31.4","31.4","15.875",0,"15.627",306770000,12,"0.261149",1,"4.92146","0.65523","tr|K7ES31|K7ES31_HUMAN;tr|K7ERF1|K7ERF1_HUMAN;sp|Q9UBQ5|EIF3K_HUMAN;tr|K7EQM4|K7EQM4_HUMAN;tr|A0A087WVB9|A0A087WVB9_HUMAN","tr|K7ES31|K7ES31_HUMAN;tr|K7ERF1|K7ERF1_HUMAN;sp|Q9UBQ5|EIF3K_HUMAN",4968,"K7ES31","K7ES31_HUMAN",null,null,"EIF3K"]
[1,"16.704","18.5408","19.5612",1,1,{"$nulls":3},"protein transport;vesicle-mediated transport",null,"integral component of membrane;membrane",{"$nulls":3},1,1,1,17,17,17,"17.804","0.00042872","4.9643",7570200,2,"0.230584",1,"4.89456","0.588123","sp|Q8WV19|SFT2A_HUMAN","sp|Q8WV19|SFT2A_HUMAN",3611,"Q8WV19","SFT2A_HUMAN","Vesicle transport protein SFT2A",null,"SFT2D1"]
["17.0531","14.9054",1,1,"16.3738",1,{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},2,1,1,"8.8","4.6","4.6","28.856","0.0026641","2.8766",7723200,1,"0.271182",1,"4.86159","0.67694","tr|J3KT43|J3KT43_HUMAN;sp|Q9UHQ1|NARF_HUMAN;tr|E7EP87|E7EP87_HUMAN;tr|A0A088AWN8|A0A088AWN8_HUMAN;tr|J3QRB0|J3QRB0_HUMAN;tr|J3KS48|J3KS48_HUMAN;tr|E9PH27|E9PH27_HUMAN","tr|J3KT43|J3KT43_HUMAN;sp|Q9UHQ1|NARF_HUMAN;tr|E7EP87|E7EP87_HUMAN;tr|A0A088AWN8|A0A088AWN8_HUMAN;tr|J3QRB0|J3QRB0_HUMAN;tr|J3KS48|J3KS48_HUMAN;tr|E9PH27|E9PH27_HUMAN",5028,"J3KT43","J3KT43_HUMAN",null,null,"NARF"]
[1,"15.9201","15.2449",1,"15.6032",1,{"$nulls":4},"phosphatidylinositol binding",{"$nulls":4},3,3,3,6,6,6,"64.079","0.0023033","3.0153",34400000,3,"0.284398",1,"4.85392","0.705316","tr|C9J715|C9J715_HUMAN;sp|Q9Y2I1|NISCH_HUMAN","tr|C9J715|C9J715_HUMAN;sp|Q9Y2I1|NISCH_HUMAN",5224,"C9J715","C9J715_HUMAN",null,null,"NISCH"]
["16.383","14.1585","15.3231",1,"13.753","16.6833",{"$nulls":3},"cellular sodium ion homeostasis;excretion;ion transmembrane transport;negative regulation of potassium ion transmembrane transport;negative regulation of potassium ion transmembrane transporter activity;negative regulation of protein localization to cell surface;negative regulation of sodium ion transmembrane transport;negative regulation of sodium ion transmembrane transporter activity;negative regulation of transcription from RNA polymerase II promoter;positive regulation of caveolin-mediated endocytosis;positive regulation of dendrite extension;positive regulation of endocytosis;positive regulation of protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K48-linked ubiquitination;protein monoubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of ion transmembrane transport;regulation of membrane depolarization;regulation of membrane potential;regulation of membrane repolarization;regulation of potassium ion transmembrane transporter activity;regulation of protein catabolic process;response to metal ion;sodium ion transport;ventricular cardiac muscle cell action potential;viral life cycle;water homeostasis","ion channel binding;potassium channel inhibitor activity;potassium channel regulator activity;sodium channel inhibitor activity;sodium channel regulator activity;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;Golgi apparatus;intracellular;multivesicular body;nucleoplasm","Aldosterone-regulated sodium reabsorption;Endocytosis;Tight junction;Ubiquitin mediated proteolysis",null,null,3,3,3,"4.3","4.3","4.3","111.93",0,"7.2058",20630000,5,"0.422364",1,"4.8094","0.990209","sp|Q96PU5|NED4L_HUMAN;tr|H0Y8H4|H0Y8H4_HUMAN;tr|K7ERN1|K7ERN1_HUMAN","sp|Q96PU5|NED4L_HUMAN",3997,"Q96PU5","NED4L_HUMAN","E3 ubiquitin-protein ligase NEDD4-like",null,"NEDD4L"]
[1,"17.1489","17.4844",1,1,"19.2322",{"$nulls":4},"RNA binding","chromosome;fibrillar center;nucleolus",{"$nulls":3},11,11,11,"40.1","40.1","40.1","33.231",0,"36.454",268980000,30,"0.230774",1,"4.80036","0.588545","sp|Q6PK04|CC137_HUMAN;tr|I3L0U5|I3L0U5_HUMAN;tr|I3L4F6|I3L4F6_HUMAN","sp|Q6PK04|CC137_HUMAN;tr|I3L0U5|I3L0U5_HUMAN",3039,"Q6PK04","CC137_HUMAN","Coiled-coil domain-containing protein 137",null,"CCDC137"]
[1,"15.1637","16.4527","16.3063",1,1,{"$nulls":4},"ATP binding",{"$nulls":4},5,5,5,"18.4","18.4","18.4","38.615","0.00021692","5.2574",16824000,4,"0.268434",1,"4.77004","0.671008","sp|Q96EK9|KTI12_HUMAN","sp|Q96EK9|KTI12_HUMAN",3856,"Q96EK9","KTI12_HUMAN","Protein KTI12 homolog",null,"KTI12"]
[1,"14.9675","16.7543",1,1,"16.6323",{"$nulls":4},"hydrolase activity",{"$nulls":4},2,2,2,"11.1","11.1","11.1","21.809","0.00042034","4.4977",4980400,1,"0.259462",1,"4.69654","0.651565","tr|K7EIN2|K7EIN2_HUMAN;sp|Q9BRJ7|SDOS_HUMAN;tr|K7ENA3|K7ENA3_HUMAN;sp|Q96DE0|NUD16_HUMAN","tr|K7EIN2|K7EIN2_HUMAN;sp|Q9BRJ7|SDOS_HUMAN;tr|K7ENA3|K7ENA3_HUMAN;sp|Q96DE0|NUD16_HUMAN",4163,"K7EIN2","K7EIN2_HUMAN",null,null,"NUDT16L1"]
["22.2324","15.3529","21.4032","22.132",1,"21.8201",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;mRNA splicing, via spliceosome;RNA processing","U6 snRNA binding","catalytic step 2 spliceosome;cytosol;Lsm1-7-Pat1 complex;nucleoplasm;spliceosomal tri-snRNP complex;U12-type spliceosomal complex;U2-type prespliceosome;U6 snRNP","RNA degradation;Spliceosome",null,null,2,2,2,32,32,32,"11.602",0,"24.393",102530000,3,"0.253732",1,"4.67877","0.639085","sp|Q9UK45|LSM7_HUMAN;tr|A0A087X2I5|A0A087X2I5_HUMAN","sp|Q9UK45|LSM7_HUMAN;tr|A0A087X2I5|A0A087X2I5_HUMAN",5077,"Q9UK45","LSM7_HUMAN","U6 snRNA-associated Sm-like protein LSm7",null,"LSM7"]
["18.6964","13.2608","17.3007","17.0296",1,"17.1953",{"$nulls":3},"fatty acid beta-oxidation;fatty acid biosynthetic process;fatty acid metabolic process","trans-2-enoyl-CoA reductase (NADPH) activity","mitochondrial matrix;mitochondrion;nucleus","Fatty acid biosynthesis;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways",null,null,3,3,3,"16.4","16.4","16.4","40.461",0,"7.2446",13943000,4,"0.345342",1,"4.67766","0.833382","sp|Q9BV79|MECR_HUMAN;tr|H3BM30|H3BM30_HUMAN","sp|Q9BV79|MECR_HUMAN",4242,"Q9BV79","MECR_HUMAN","Enoyl-[acyl-carrier-protein] reductase, mitochondrial {ECO:0000305}",null,"MECR"]
["15.8653","15.1505","16.6233","16.7494",1,"15.9877",{"$nulls":9},2,2,2,3,3,3,"129.6",0,"8.8473",37792000,3,"0.378103",1,"4.63403","0.900657","tr|A0A075B6T1|A0A075B6T1_HUMAN;sp|Q9C0C7|AMRA1_HUMAN;tr|H0YE34|H0YE34_HUMAN","tr|A0A075B6T1|A0A075B6T1_HUMAN;sp|Q9C0C7|AMRA1_HUMAN;tr|H0YE34|H0YE34_HUMAN",4349,"A0A075B6T1","A0A075B6T1_HUMAN",null,null,"AMBRA1"]
["15.9861","15.2054",1,"16.3331",1,1,{"$nulls":3},"cellular response to electrical stimulus;cytoskeleton organization;movement of cell or subcellular component;negative regulation of adenylate cyclase activity;negative regulation of dopamine receptor signaling pathway;positive regulation of filopodium assembly;protein localization to plasma membrane;regulation of cell shape;synapse maturation","D3 dopamine receptor binding","apicolateral plasma membrane;axon;basolateral plasma membrane;cytoplasmic vesicle;dendritic spine membrane;filopodium membrane;integral component of plasma membrane;intracellular membrane-bounded organelle;nucleus;plasma membrane;postsynaptic density",{"$nulls":3},3,3,3,"13.4","13.4","13.4","42.075",0,"10.197",21486000,6,"0.260724",1,"4.61943","0.654307","sp|O75781|PALM_HUMAN;tr|A0A087WWY4|A0A087WWY4_HUMAN;tr|A0A087WTK8|A0A087WTK8_HUMAN","sp|O75781|PALM_HUMAN",630,"O75781","PALM_HUMAN","Paralemmin-1",null,"PALM"]
["16.4226","16.0172","15.8033",1,"16.3906","17.0386",{"$nulls":3},"endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosome assembly;rRNA processing","ATP binding;GTP binding;GTPase activity;RNA binding;U3 snoRNA binding","90S preribosome;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes",null,null,12,12,12,"11.5","11.5","11.5","145.81",0,"30.403",168740000,22,"0.366996",1,"4.60461","0.877955","sp|Q14692|BMS1_HUMAN","sp|Q14692|BMS1_HUMAN",2498,"Q14692","BMS1_HUMAN","Ribosome biogenesis protein BMS1 homolog",null,"BMS1"]
["14.0812","13.6522","12.4626","14.6908","10.7438",1,{"$nulls":3},"angiogenesis;branching involved in salivary gland morphogenesis;branching involved in ureteric bud morphogenesis;cell differentiation;cell migration;cell proliferation;cell recognition;cilium assembly;cytoskeleton organization;embryo development;endothelial cell differentiation;extracellular matrix organization;focal adhesion assembly;hair follicle development;integrin-mediated signaling pathway;lung development;morphogenesis of a polarized epithelium;morphogenesis of embryonic epithelium;muscle organ development;neural crest cell migration;odontogenesis of dentin-containing tooth;protein localization to plasma membrane;regulation of cell adhesion;regulation of cell migration;regulation of cell proliferation;regulation of embryonic development;substrate adhesion-dependent cell spreading","integrin binding;structural molecule activity","basal lamina;basement membrane;extracellular exosome;extracellular matrix;extracellular region;extracellular space;laminin-10 complex;laminin-11 complex;laminin-5 complex;nucleus;synaptic cleft","Amoebiasis;ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Pathways in cancer;PI3K-Akt signaling pathway;Small cell lung cancer;Toxoplasmosis",null,null,8,8,8,"2.9","2.9","2.9","399.73",0,"22.678",60665000,16,"0.487334",1,"4.58713","1.11956","sp|O15230|LAMA5_HUMAN","sp|O15230|LAMA5_HUMAN",349,"O15230","LAMA5_HUMAN","Laminin subunit alpha-5",null,"LAMA5"]
["17.4596","16.1129","15.5578","18.5325","15.8746",1,{"$nulls":3},"cellular response to insulin stimulus;insulin receptor signaling pathway via phosphatidylinositol 3-kinase;intracellular protein transmembrane transport;positive regulation of glucose import in response to insulin stimulus;positive regulation of glucose transport;positive regulation of protein targeting to membrane;positive regulation of vesicle fusion;protein localization to plasma membrane;vesicle fusion","calcium ion binding;calcium-dependent phospholipid binding","cell cortex;cytoplasmic vesicle membrane;cytosol;microtubule organizing center;plasma membrane;ruffle membrane",{"$nulls":3},16,16,16,"25.3","25.3","25.3","110.45",0,"112.48",536130000,44,"0.345664",1,"4.57439","0.834048","sp|Q86YS7|C2CD5_HUMAN;tr|H0YFE9|H0YFE9_HUMAN;tr|H0YGU7|H0YGU7_HUMAN;tr|H0YFC4|H0YFC4_HUMAN","sp|Q86YS7|C2CD5_HUMAN",3271,"Q86YS7","C2CD5_HUMAN","C2 domain-containing protein 5",null,"C2CD5"]
["18.2718","15.6925","19.058","19.5269",1,"18.8862",{"$nulls":3},"cell cycle;cell division;double-strand break repair;double-strand break repair via nonhomologous end joining;histone H2A K63-linked deubiquitination;positive regulation of DNA repair;protein deubiquitination;protein K63-linked deubiquitination;response to ionizing radiation;response to X-ray;signal transduction involved in G2 DNA damage checkpoint","enzyme regulator activity;Lys63-specific deubiquitinase activity;metal ion binding;metallopeptidase activity;polyubiquitin modification-dependent protein binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity","BRCA1-A complex;BRISC complex;cytoplasm;cytosol;nuclear ubiquitin ligase complex;nucleoplasm;nucleus;spindle pole;ubiquitin ligase complex","Homologous recombination;NOD-like receptor signaling pathway",null,null,3,3,3,"13.6","13.6","13.6","36.072",0,"8.564",77306000,7,"0.299235",1,"4.53644","0.736895","sp|P46736|BRCC3_HUMAN;tr|X6RJS7|X6RJS7_HUMAN;tr|A0A087WZR3|A0A087WZR3_HUMAN;tr|H9KVA9|H9KVA9_HUMAN;tr|A0A0D9SF50|A0A0D9SF50_HUMAN;tr|A0A0A0MS96|A0A0A0MS96_HUMAN","sp|P46736|BRCC3_HUMAN;tr|X6RJS7|X6RJS7_HUMAN;tr|A0A087WZR3|A0A087WZR3_HUMAN;tr|H9KVA9|H9KVA9_HUMAN;tr|A0A0D9SF50|A0A0D9SF50_HUMAN",1595,"P46736","BRCC3_HUMAN","Lys-63-specific deubiquitinase BRCC36",null,"BRCC3"]
["15.9337","15.3595","15.1928",1,"16.1962","15.6902",{"$nulls":3},"cell adhesion;N-acetylglucosamine biosynthetic process;N-acetylneuraminate metabolic process;UDP-N-acetylglucosamine metabolic process","ATP binding;hydrolase activity, hydrolyzing O-glycosyl compounds;metal ion binding;N-acylmannosamine kinase activity;UDP-N-acetylglucosamine 2-epimerase activity","cytoplasm;cytosol","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,4,4,4,"7.2","7.2","7.2","79.274",0,"12.326",30166000,4,"0.382091",1,"4.53325","0.908785","sp|Q9Y223|GLCNE_HUMAN","sp|Q9Y223|GLCNE_HUMAN",5196,"Q9Y223","GLCNE_HUMAN","Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase",null,"GNE"]
["15.0394","13.6279","15.0307","15.4701","13.654",1,{"$nulls":3},"calcium ion import;cell adhesion;negative regulation of cell-matrix adhesion;negative regulation of cellular response to growth factor stimulus;negative regulation of keratinocyte proliferation;negative regulation of wound healing;neurotransmitter secretion;positive regulation of calcium ion import;positive regulation of transcription from RNA polymerase II promoter","ATP binding;calmodulin binding;guanylate kinase activity;neurexin family protein binding;protein serine/threonine kinase activity","actin cytoskeleton;basement membrane;basolateral plasma membrane;cell-cell junction;ciliary membrane;cytoplasm;cytosol;focal adhesion;nuclear lamina;nuclear matrix;nucleolus;plasma membrane;presynaptic membrane;vesicle",{"$nulls":3},6,6,6,"8.3","8.3","8.3","105.12",0,"7.0932",23663000,4,"0.42175",1,"4.52464","0.988976","sp|O14936|CSKP_HUMAN;tr|Q5JS79|Q5JS79_HUMAN;tr|Q5JS72|Q5JS72_HUMAN;tr|Q5JS74|Q5JS74_HUMAN","sp|O14936|CSKP_HUMAN;tr|Q5JS79|Q5JS79_HUMAN;tr|Q5JS72|Q5JS72_HUMAN;tr|Q5JS74|Q5JS74_HUMAN",311,"O14936","CSKP_HUMAN","Peripheral plasma membrane protein CASK","CASK","CASK"]
["18.9294","12.4699","19.4001","16.3741",1,"19.8652",{"$nulls":3},"DNA damage checkpoint","ATP binding;protein serine/threonine kinase activity","intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},4,4,4,"17.4","17.4","17.4","49.019",0,"29.824",57167000,8,"0.294912",1,"4.52004","0.727724","tr|J3KN87|J3KN87_HUMAN;sp|O14757|CHK1_HUMAN;tr|E7EPP6|E7EPP6_HUMAN;tr|E9PJI4|E9PJI4_HUMAN;tr|E9PKQ3|E9PKQ3_HUMAN;tr|E9PM65|E9PM65_HUMAN;tr|E9PQW7|E9PQW7_HUMAN;tr|E9PPA5|E9PPA5_HUMAN","tr|J3KN87|J3KN87_HUMAN;sp|O14757|CHK1_HUMAN;tr|E7EPP6|E7EPP6_HUMAN;tr|E9PJI4|E9PJI4_HUMAN;tr|E9PKQ3|E9PKQ3_HUMAN",292,"J3KN87","J3KN87_HUMAN",null,null,"CHEK1"]
["15.4304","14.6847","15.431","16.1382",1,"14.8604",{"$nulls":3},"brown fat cell differentiation;cell adhesion;endodermal cell differentiation;epidermis development;extracellular matrix disassembly;extracellular matrix organization;hemidesmosome assembly","protein complex binding;structural molecule activity","extracellular region;laminin-5 complex","Amoebiasis;ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Pathways in cancer;PI3K-Akt signaling pathway;Small cell lung cancer;Toxoplasmosis",null,null,3,3,3,"4.4","4.4","4.4","129.57",0,"21.019",43145000,8,"0.39274",1,"4.51585","0.930428","sp|Q13751|LAMB3_HUMAN;tr|Q5THA1|Q5THA1_HUMAN","sp|Q13751|LAMB3_HUMAN",2407,"Q13751","LAMB3_HUMAN","Laminin subunit beta-3",null,"LAMB3"]
["16.991","15.0137",1,"17.5417",1,1,{"$nulls":3},"multicellular organism development","DNA binding transcription factor activity;sequence-specific DNA binding","nucleoplasm",{"$nulls":3},3,3,2,12,12,"8.7","27.502",0,"7.0667",77568000,9,"0.236443",1,"4.48768","0.601106","tr|I3L3R1|I3L3R1_HUMAN;sp|P17481|HXB8_HUMAN;tr|I3L383|I3L383_HUMAN;sp|P31273|HXC8_HUMAN;tr|A0A0A0MSX5|A0A0A0MSX5_HUMAN;tr|V9GYH0|V9GYH0_HUMAN;tr|A0A0A0MTF4|A0A0A0MTF4_HUMAN;sp|Q00444|HXC5_HUMAN;sp|P17509|HXB6_HUMAN;sp|P31268|HXA7_HUMAN;sp|P31267|HXA6_HUMAN;sp|P09630|HXC6_HUMAN;sp|P17482|HXB9_HUMAN;sp|P31274|HXC9_HUMAN;sp|P09067|HXB5_HUMAN;sp|P20719|HXA5_HUMAN;sp|P13378|HXD8_HUMAN;tr|A0A087X222|A0A087X222_HUMAN;sp|P28356|HXD9_HUMAN","tr|I3L3R1|I3L3R1_HUMAN;sp|P17481|HXB8_HUMAN;tr|I3L383|I3L383_HUMAN;sp|P31273|HXC8_HUMAN",1155,"I3L3R1","I3L3R1_HUMAN"]
[1,"15.1185","14.5853",1,"15.3805",1,{"$nulls":4},"GTP binding;GTPase activator activity;GTPase activity","mitochondrion;nucleolus;nucleus",{"$nulls":3},9,9,9,"12.3","12.3","12.3","108.53",0,"21.862",112240000,13,"0.266624",1,"4.4411","0.667094","tr|J3KNM6|J3KNM6_HUMAN;tr|F8VVT9|F8VVT9_HUMAN;sp|Q99490|AGAP2_HUMAN;tr|H0YHB1|H0YHB1_HUMAN","tr|J3KNM6|J3KNM6_HUMAN;tr|F8VVT9|F8VVT9_HUMAN;sp|Q99490|AGAP2_HUMAN",4066,"J3KNM6","J3KNM6_HUMAN",null,null,"AGAP2"]
[1,"15.0567","15.3639",1,1,"16.133",{"$nulls":3},"negative regulation of transcription, DNA-templated;positive regulation of transcription from RNA polymerase II promoter","RNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nucleolus;nucleus",{"$nulls":3},3,3,3,"4.6","4.6","4.6","77.672","0.0019324","3.1002",9349500,0,"0.254168",1,"4.42922","0.640036","sp|O15226|NKRF_HUMAN;tr|A0A087WXT2|A0A087WXT2_HUMAN","sp|O15226|NKRF_HUMAN",347,"O15226","NKRF_HUMAN","NF-kappa-B-repressing factor","FkB-repressing factor","NKRF"]
[1,"15.6621","15.6452","17.0445",1,1,{"$nulls":3},"cell adhesion;cellular response to DNA damage stimulus;embryonic cleavage;negative regulation of amyloid precursor protein biosynthetic process;negative regulation of apoptotic process;negative regulation of reactive oxygen species metabolic process;negative regulation of superoxide anion generation;positive regulation of transcription from RNA polymerase II promoter;regulation of mitotic cell cycle;ribosome biogenesis","DNA binding transcription factor activity;leucine zipper domain binding;RNA binding;tau protein binding","cytoplasm;Golgi apparatus;nucleolus;nucleus",{"$nulls":3},8,8,8,"22.1","22.1","22.1","63.132",0,"52.444",217520000,26,"0.240639",1,"4.42094","0.61037","sp|Q9NY61|AATF_HUMAN;tr|A0A087WWS8|A0A087WWS8_HUMAN;tr|A0A087WTH8|A0A087WTH8_HUMAN;tr|A0A087WW41|A0A087WW41_HUMAN","sp|Q9NY61|AATF_HUMAN",4845,"Q9NY61","AATF_HUMAN","Protein AATF",null,"AATF"]
["16.0779","15.1437","14.5523",1,"15.8825","15.7067",{"$nulls":3},"translation","GTP binding;GTPase activity","mitochondrial inner membrane",{"$nulls":3},12,12,12,"27.5","27.5","27.5","74.327",0,"108.82",278570000,32,"0.371679",1,"4.39488","0.88754","sp|Q8N442|GUF1_HUMAN","sp|Q8N442|GUF1_HUMAN",3395,"Q8N442","GUF1_HUMAN","Translation factor GUF1, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03137}",null,"GUF1"]
["15.4391","15.736","15.9536","17.5489","15.3998",1,{"$nulls":3},"anion transmembrane transport;signal transduction;transmembrane transport","volume-sensitive anion channel activity","cytoplasm;endoplasmic reticulum membrane;integral component of plasma membrane;ion channel complex;plasma membrane",{"$nulls":3},4,4,4,"8.2","8.2","8.2","90.246",0,"9.7695",30033000,4,"0.351104",1,"4.39332","0.845284","sp|Q6NSJ5|LRC8E_HUMAN;tr|M0R2K8|M0R2K8_HUMAN;tr|M0R2D8|M0R2D8_HUMAN;tr|M0QZ48|M0QZ48_HUMAN","sp|Q6NSJ5|LRC8E_HUMAN",2974,"Q6NSJ5","LRC8E_HUMAN","Volume-regulated anion channel subunit LRRC8E",null,"LRRC8E"]
["17.2807","16.0704","16.4651","19.4892","16.1575",1,{"$nulls":3},"cell cycle arrest;cellular response to transforming growth factor beta stimulus;dephosphorylation;negative regulation of BMP signaling pathway;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of NF-kappaB import into nucleus;negative regulation of SMAD protein complex assembly;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transforming growth factor beta receptor signaling pathway;N-terminal protein myristoylation;peptidyl-threonine dephosphorylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of protein export from nucleus;positive regulation of transcription, DNA-templated;positive regulation of Wnt signaling pathway;protein dephosphorylation;Wnt signaling pathway","calmodulin-dependent protein phosphatase activity;magnesium ion binding;manganese ion binding;protein serine/threonine phosphatase activity;R-SMAD binding;signal transducer activity","cytosol;membrane;nucleoplasm;nucleus;plasma membrane","MAPK signaling pathway",null,null,4,2,2,11,"5.2","5.2","42.447","0.0010087","3.6868",72206000,3,"0.314941",1,"4.3898","0.770029","sp|P35813|PPM1A_HUMAN;tr|E9PKB5|E9PKB5_HUMAN;tr|E9PL75|E9PL75_HUMAN;tr|E9PJN3|E9PJN3_HUMAN","sp|P35813|PPM1A_HUMAN;tr|E9PKB5|E9PKB5_HUMAN;tr|E9PL75|E9PL75_HUMAN;tr|E9PJN3|E9PJN3_HUMAN",1474,"P35813","PPM1A_HUMAN","Protein phosphatase 1A",null,"PPM1A"]
["16.5699","14.796",1,1,"17.3559",1,{"$nulls":3},"blastocyst formation;cytoplasmic translation;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","RNA binding;structural constituent of ribosome","cytosolic large ribosomal subunit;nucleolus",{"$nulls":3},5,5,1,"21.5","21.5","4.5","28.661",0,"10.076",72344000,16,"0.231644",1,"4.3367","0.590475","sp|Q6DKI1|RL7L_HUMAN","sp|Q6DKI1|RL7L_HUMAN",2945,"Q6DKI1","RL7L_HUMAN","60S ribosomal protein L7-like 1",null,"RPL7L1"]
["15.0374","13.2916","16.145","15.7016","14.8062",1,{"$nulls":3},"transcription from RNA polymerase II promoter","DNA binding;DNA-directed 5'-3' RNA polymerase activity","nucleus",{"$nulls":3},4,4,4,"4.8","4.8","4.8","152.75","0.0010028","3.5986",22015000,3,"0.375226",1,"4.32205","0.894787","sp|Q9BWH6|RPAP1_HUMAN;tr|H3BRE8|H3BRE8_HUMAN","sp|Q9BWH6|RPAP1_HUMAN;tr|H3BRE8|H3BRE8_HUMAN",4280,"Q9BWH6","RPAP1_HUMAN","RNA polymerase II-associated protein 1",null,"RPAP1"]
[1,"13.9778","18.1481",1,1,"18.3004",{"$nulls":9},3,3,3,"8.5","8.5","8.5","63.569",0,"9.5934",85618000,9,"0.214568",1,"4.27518","0.552311","tr|H0YE03|H0YE03_HUMAN;tr|H7C3G7|H7C3G7_HUMAN;sp|Q2TBE0|C19L2_HUMAN","tr|H0YE03|H0YE03_HUMAN;tr|H7C3G7|H7C3G7_HUMAN;sp|Q2TBE0|C19L2_HUMAN",2726,"H0YE03","H0YE03_HUMAN",null,null,"CWF19L2"]
["17.625","14.5193","16.3479","17.8009",1,"17.1123",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding;zinc ion binding","catalytic step 2 spliceosome;nuclear body;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"9.2","9.2","9.2","78.576",0,"7.2709",51256000,7,"0.307223",1,"4.19302","0.753784","sp|Q6NZY4|ZCHC8_HUMAN;tr|F5H803|F5H803_HUMAN;tr|F5H6J5|F5H6J5_HUMAN;tr|F5GX80|F5GX80_HUMAN;tr|F5GXQ6|F5GXQ6_HUMAN","sp|Q6NZY4|ZCHC8_HUMAN;tr|F5H803|F5H803_HUMAN;tr|F5H6J5|F5H6J5_HUMAN;tr|F5GX80|F5GX80_HUMAN;tr|F5GXQ6|F5GXQ6_HUMAN",2992,"Q6NZY4","ZCHC8_HUMAN","Zinc finger CCHC domain-containing protein 8",null,"ZCCHC8"]
["17.3648","14.6664","16.2523","17.4715",1,"17.3047",{"$nulls":5},"mitochondrion",{"$nulls":3},6,6,6,"18.8","18.8","18.8","37.001",0,"17.787",59769000,14,"0.30801",1,"4.16909","0.755442","sp|Q3SXM5|HSDL1_HUMAN;tr|H3BQI7|H3BQI7_HUMAN;tr|H3BT52|H3BT52_HUMAN;tr|H3BNH5|H3BNH5_HUMAN","sp|Q3SXM5|HSDL1_HUMAN",2742,"Q3SXM5","HSDL1_HUMAN","Inactive hydroxysteroid dehydrogenase-like protein 1",null,"HSDL1"]
["19.063","16.0084","16.9166","19.5915",1,"18.8999",{"$nulls":3},"glutaminyl-tRNAGln biosynthesis via transamidation;mitochondrial translation","ATP binding;glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity","glutamyl-tRNA(Gln) amidotransferase complex;mitochondrion",{"$nulls":3},5,5,5,"14.9","14.9","14.9","57.653",0,"35.918",72352000,9,"0.271247",1,"4.16553","0.67708","tr|D6REA0|D6REA0_HUMAN;sp|O75879|GATB_HUMAN;tr|D6RDU9|D6RDU9_HUMAN","tr|D6REA0|D6REA0_HUMAN;sp|O75879|GATB_HUMAN;tr|D6RDU9|D6RDU9_HUMAN",642,"D6REA0","D6REA0_HUMAN","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial {ECO:0000256|HAMAP-Rule:MF_03147}","lu-AdT subunit B {ECO:0000256|HAMAP-Rule:MF_03147}"]
[1,"13.3062","14.9081",1,1,"14.7469",{"$nulls":3},"cell division;cellular response to DNA damage stimulus;cellular senescence;double-strand break repair via homologous recombination;positive regulation of chromosome segregation;positive regulation of maintenance of mitotic sister chromatid cohesion;sister chromatid cohesion;telomere maintenance via recombination","ATP binding","cell junction;chromosome, telomeric region;interchromatin granule;nuclear speck;nucleoplasm;nucleus;PML body;sex chromosome;site of double-strand break;Smc5-Smc6 complex",{"$nulls":3},4,4,4,"3.9","3.9","3.9","128.81",0,"7.3122",14520000,2,"0.260877",1,"4.1558","0.65464","sp|Q8IY18|SMC5_HUMAN","sp|Q8IY18|SMC5_HUMAN",3329,"Q8IY18","SMC5_HUMAN","Structural maintenance of chromosomes protein 5","MC protein 5;MC-5;SMC5","SMC5"]
["13.5828","17.7852","14.963","15.0849","17.8609",1,{"$nulls":3},"defense response to virus;innate immune response;positive regulation of MDA-5 signaling pathway;positive regulation of RIG-I signaling pathway;response to virus","ATP binding;double-stranded DNA binding;double-stranded RNA binding;helicase activity;single-stranded RNA binding","cytoplasm;cytosol;intermediate filament cytoskeleton",{"$nulls":3},24,24,23,"18.6","18.6","17.8","197.85",0,"81.636",505400000,63,"0.314762",1,"4.12842","0.769651","sp|Q8IY21|DDX60_HUMAN;tr|H0Y8Z7|H0Y8Z7_HUMAN;tr|D6R944|D6R944_HUMAN","sp|Q8IY21|DDX60_HUMAN",3330,"Q8IY21","DDX60_HUMAN","Probable ATP-dependent RNA helicase DDX60",null,"DDX60"]
["17.3144","14.1829","15.313","17.041","16.4375",1,{"$nulls":3},"blood coagulation;regulation of protein kinase A signaling","protein kinase A regulatory subunit binding;RNA binding","cytosol;integral component of membrane;membrane;mitochondrial outer membrane;mitochondrion",{"$nulls":3},4,4,4,"6.6","6.6","6.6","97.34",0,"8.2967",40627000,3,"0.315604",1,"4.11057","0.771421","sp|Q92667|AKAP1_HUMAN;tr|I3L0W0|I3L0W0_HUMAN;tr|I3L3K1|I3L3K1_HUMAN;tr|I3L364|I3L364_HUMAN;tr|I3L0K6|I3L0K6_HUMAN;tr|I3L2A2|I3L2A2_HUMAN;tr|I3L2N7|I3L2N7_HUMAN;tr|I3NI36|I3NI36_HUMAN","sp|Q92667|AKAP1_HUMAN;tr|I3L0W0|I3L0W0_HUMAN",3700,"Q92667","AKAP1_HUMAN","A-kinase anchor protein 1, mitochondrial",null,"AKAP1"]
["16.8311","14.342","16.3775","17.2192",1,"17.1352",{"$nulls":3},"adaptive immune response;immune response;mucosal immune response;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interleukin-8 production;negative regulation of protein localization to nucleus;negative regulation of transcription from RNA polymerase II promoter;protein deubiquitination;protein deubiquitination involved in ubiquitin-dependent protein catabolic process;protein K11-linked deubiquitination;protein K48-linked deubiquitination;protein K63-linked deubiquitination","cysteine-type peptidase activity;DNA binding;K63-linked polyubiquitin modification-dependent protein binding;Lys48-specific deubiquitinase activity;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;zinc ion binding","cytoplasm;cytosol;nucleus",{"$nulls":3},3,3,3,"5.2","5.2","5.2","92.525",0,"11.725",33022000,6,"0.303737",1,"4.0654","0.746423","sp|Q6GQQ9|OTU7B_HUMAN;tr|Q5SZ59|Q5SZ59_HUMAN;sp|Q8TE49|OTU7A_HUMAN","sp|Q6GQQ9|OTU7B_HUMAN;tr|Q5SZ59|Q5SZ59_HUMAN",2954,"Q6GQQ9","OTU7B_HUMAN","OTU domain-containing protein 7B",null,"OTUD7B"]
["14.7954","13.8466","14.2453","15.4113",1,"14.3047",{"$nulls":3},"inflammatory response;negative regulation of MHC class II biosynthetic process;negative regulation of transcription from RNA polymerase II promoter;transcription from RNA polymerase II promoter;viral process","DNA binding transcription factor activity;ligase activity;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;zinc ion binding","cytosol;nucleolus;nucleus;plasma membrane","Human papillomavirus infection",null,null,1,1,1,"1.7","1.7","1.7","124.39",0,"5.6655",10377000,3,"0.365386",1,"4.05711","0.874656","sp|Q12986|NFX1_HUMAN","sp|Q12986|NFX1_HUMAN",2291,"Q12986","NFX1_HUMAN","Transcriptional repressor NF-X1",null,"NFX1"]
["13.8341","12.7189","13.1362","13.9937","12.7962",1,{"$nulls":4},"ubiquitin-protein transferase activity",{"$nulls":4},3,3,3,1,1,1,"484.35",0,"20.472",41868000,6,"0.404251",1,"3.9664","0.953728","tr|J3KPF0|J3KPF0_HUMAN;sp|Q9Y4D8|HECD4_HUMAN;tr|F8VWT9|F8VWT9_HUMAN","tr|J3KPF0|J3KPF0_HUMAN;sp|Q9Y4D8|HECD4_HUMAN;tr|F8VWT9|F8VWT9_HUMAN",5586,"J3KPF0","J3KPF0_HUMAN",null,null,"HECTD4"]
["19.4842","11.1762","16.3935","17.5005",1,"16.8798",{"$nulls":4},"DNA binding;transcription coactivator activity","cytosol;nucleoplasm",{"$nulls":3},1,1,1,"4.4","4.4","4.4","51.233",0,"10.353",16917000,2,"0.262154",1,"3.89121","0.657413","tr|Q5JTV1|Q5JTV1_HUMAN;sp|Q9UKD1|GMEB2_HUMAN","tr|Q5JTV1|Q5JTV1_HUMAN;sp|Q9UKD1|GMEB2_HUMAN",5084,"Q5JTV1","Q5JTV1_HUMAN"]
["16.5736","18.0273","20.942","21.6558",1,"21.3492",{"$nulls":5},"intracellular",{"$nulls":3},5,5,5,"18.8","18.8","18.8","49.193",0,"8.978",259760000,4,"0.214889",1,"3.84599","0.553033","tr|M0R366|M0R366_HUMAN;sp|Q9BTV5|FSD1_HUMAN;tr|M0R1R0|M0R1R0_HUMAN;tr|M0R2F6|M0R2F6_HUMAN","tr|M0R366|M0R366_HUMAN;sp|Q9BTV5|FSD1_HUMAN",4213,"M0R366","M0R366_HUMAN",null,null,"FSD1"]
["13.0081","12.1722","13.247","13.3529","12.5491",1,{"$nulls":3},"positive regulation of canonical Wnt signaling pathway;protein deubiquitination;protein K48-linked deubiquitination;ubiquitin-dependent protein catabolic process;Wnt signaling pathway","cysteine-type endopeptidase activity;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity","cytosol",{"$nulls":3},3,3,3,"1.5","1.5","1.5","404.23","0.00061589","4.0465",13178000,1,"0.407136",1,"3.84175","0.959551","sp|Q70CQ2|UBP34_HUMAN;tr|A0A0C4DG73|A0A0C4DG73_HUMAN;tr|H7C150|H7C150_HUMAN;tr|H7C183|H7C183_HUMAN","sp|Q70CQ2|UBP34_HUMAN;tr|A0A0C4DG73|A0A0C4DG73_HUMAN",3096,"Q70CQ2","UBP34_HUMAN","Ubiquitin carboxyl-terminal hydrolase 34",null,"USP34"]
["15.086","14.4054",1,"16.9763",1,1,{"$nulls":3},"cilium assembly;determination of left/right symmetry;heart development;intraciliary transport involved in cilium assembly;keratinocyte development;negative regulation of epithelial cell proliferation;non-motile cilium assembly;Notch signaling pathway;positive regulation of cell adhesion mediated by integrin;positive regulation of transcription from RNA polymerase II promoter","beta-tubulin binding;chromatin binding","centrosome;ciliary tip;cilium;cytoplasmic vesicle;intraciliary transport particle B;motile cilium;nucleus",{"$nulls":3},2,2,2,"4.5","4.5","4.5","69.239","0.001359","3.1796",12473000,1,"0.211835",1,"3.83836","0.546152","sp|Q96LB3|IFT74_HUMAN","sp|Q96LB3|IFT74_HUMAN",3967,"Q96LB3","IFT74_HUMAN","Intraflagellar transport protein 74 homolog",null,"IFT74"]
["14.2773","12.4824",1,1,"14.2926",1,{"$nulls":3},"negative regulation of angiogenesis;negative regulation of cell proliferation;negative regulation of vascular endothelial growth factor receptor signaling pathway;positive regulation of apoptotic process;reelin-mediated signaling pathway","GTPase activator activity",{"$nulls":4},10,9,9,17,"16.4","16.4","118.06",0,"28.919",96943000,18,"0.249114",1,"3.82237","0.628988","tr|H0Y3A3|H0Y3A3_HUMAN;sp|Q5VWQ8|DAB2P_HUMAN","tr|H0Y3A3|H0Y3A3_HUMAN;sp|Q5VWQ8|DAB2P_HUMAN",2905,"H0Y3A3","H0Y3A3_HUMAN",null,null,"DAB2IP"]
["18.7044","18.8283","18.3889","17.0607","12.5616","14.8842",{"$nulls":5},"cytoskeleton",{"$nulls":3},18,18,18,"13.1","13.1","13.1","204.49",0,"78.548",375690000,31,"1.36169",1,"3.80508","2.9145","tr|K7EKI8|K7EKI8_HUMAN;sp|O60437|PEPL_HUMAN;tr|K7EQ71|K7EQ71_HUMAN","tr|K7EKI8|K7EKI8_HUMAN;sp|O60437|PEPL_HUMAN;tr|K7EQ71|K7EQ71_HUMAN",493,"K7EKI8","K7EKI8_HUMAN",null,null,"PPL"]
["15.3722","13.5305","16.7564","17.1849",1,"16.7138",{"$nulls":3},"negative regulation of protein ubiquitination;protein deubiquitination;protein localization to cell surface;regulation of protein stability;spliceosomal tri-snRNP complex assembly;ubiquitin-dependent protein catabolic process","adenosine receptor binding;identical protein binding;metal ion binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity","cytoplasm;cytosol;lysosome;nucleus;plasma membrane",{"$nulls":3},9,7,7,"14.3","11.9","11.9","108.56",0,"13.46",25371000,7,"0.265319",1,"3.58682","0.664271","sp|Q13107|UBP4_HUMAN;tr|H7C189|H7C189_HUMAN;tr|C9JNU9|C9JNU9_HUMAN","sp|Q13107|UBP4_HUMAN;tr|H7C189|H7C189_HUMAN",2305,"Q13107","UBP4_HUMAN","Ubiquitin carboxyl-terminal hydrolase 4",null,"USP4"]
["18.7443","13.1321","16.7406","18.7635",1,"18.2596",{"$nulls":3},"fatty acid elongation, saturated fatty acid;very long-chain fatty acid biosynthetic process","3-oxo-arachidoyl-CoA synthase activity;3-oxo-cerotoyl-CoA synthase activity;3-oxo-lignoceronyl-CoA synthase activity;fatty acid elongase activity;very-long-chain 3-ketoacyl-CoA synthase activity","endoplasmic reticulum;integral component of membrane",{"$nulls":3},1,1,1,5,5,5,"30.742",0,"21.123",82285000,9,"0.227918",1,"3.53128","0.582193","tr|A0A0A0MTI6|A0A0A0MTI6_HUMAN;sp|Q9NYP7|ELOV5_HUMAN","tr|A0A0A0MTI6|A0A0A0MTI6_HUMAN;sp|Q9NYP7|ELOV5_HUMAN",4856,"A0A0A0MTI6","A0A0A0MTI6_HUMAN","Elongation of very long chain fatty acids protein {ECO:0000256|RuleBase:RU361115}"]
["14.1246","13.7404",1,"16.3011",1,1,{"$nulls":3},"cellular response to DNA damage stimulus;DNA metabolic process;DNA repair;DNA replication;DNA replication initiation;mitotic DNA replication checkpoint;mitotic G2 DNA damage checkpoint;regulation of signal transduction by p53 class mediator;response to ionizing radiation","DNA binding;identical protein binding;protein C-terminus binding","actin cytoskeleton;chromosome;condensed nuclear chromosome;cytoplasm;male germ cell nucleus;microtubule organizing center;nuclear body;nucleoplasm;nucleus;PML body;spindle pole","Homologous recombination",null,null,4,4,4,"4.6","4.6","4.6","170.68",0,"8.9975",35212000,8,"0.203474",1,"3.52129","0.527216","sp|Q92547|TOPB1_HUMAN","sp|Q92547|TOPB1_HUMAN",3678,"Q92547","TOPB1_HUMAN","DNA topoisomerase 2-binding protein 1",null,"TOPBP1"]
["14.73","15.9807","16.9338","19.6614",1,"17.4044",{"$nulls":3},"actin filament organization;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;cell adhesion;cell chemotaxis;cell division;cell migration;cell proliferation;cellular response to hepatocyte growth factor stimulus;epidermal growth factor receptor signaling pathway;G-protein coupled receptor signaling pathway;hepatocyte growth factor receptor signaling pathway;insulin receptor signaling pathway;integrin-mediated signaling pathway;neurotrophin TRK receptor signaling pathway;platelet-derived growth factor receptor signaling pathway;positive regulation of cell migration;positive regulation of endothelial cell migration;regulation of apoptotic process;regulation of cell growth;T cell receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway","protein kinase binding;SH3 domain binding;signal transducer activity","actin cytoskeleton;cytoplasm;cytosol;focal adhesion;lamellipodium;ruffle","Bacterial invasion of epithelial cells;Chemokine signaling pathway;Focal adhesion;Human cytomegalovirus infection;Leukocyte transendothelial migration;Rap1 signaling pathway;Regulation of actin cytoskeleton;Yersinia infection",null,null,6,6,6,"12.5","12.5","12.5","93.371",0,"12.721",56682000,7,"0.209019",1,"3.19287","0.53979","sp|P56945|BCAR1_HUMAN;tr|H3BN62|H3BN62_HUMAN","sp|P56945|BCAR1_HUMAN",1872,"P56945","BCAR1_HUMAN","Breast cancer anti-estrogen resistance protein 1",null,"BCAR1"]
["17.0628","23.75","17.3191","14.7104","16.7382","17.1773",{"$nulls":3},"7-methylguanosine mRNA capping;DNA repair;global genome nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;phosphorylation of RNA polymerase II C-terminal domain;positive regulation of transcription from RNA polymerase II promoter;regulation of cyclin-dependent protein serine/threonine kinase activity;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase I promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair","chromatin binding","core TFIIH complex;holo TFIIH complex;nucleoplasm","Basal transcription factors;Nucleotide excision repair;Viral carcinogenesis",null,null,14,14,14,"40.3","40.3","40.3","62.031",0,"201.2",1005600000,53,"0.614318",1,"3.16866","1.36829","sp|P32780|TF2H1_HUMAN;tr|E9PM51|E9PM51_HUMAN;tr|E9PI26|E9PI26_HUMAN;tr|E9PL58|E9PL58_HUMAN;tr|F5H0Y9|F5H0Y9_HUMAN","sp|P32780|TF2H1_HUMAN",1427,"P32780","TF2H1_HUMAN","General transcription factor IIH subunit 1",null,"GTF2H1"]
["19.8849","18.1711","19.3074","17.8145","13.6773","16.4664",{"$nulls":3},"cellular response to insulin stimulus;Golgi to plasma membrane protein transport;neutrophil degranulation;phagosome maturation;receptor internalization;regulated exocytosis","GDP binding;GTP binding;GTPase activity","cytosol;early endosome;early endosome membrane;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane;secretory granule membrane;trans-Golgi network membrane","Endocytosis",null,null,3,3,1,18,18,"6.7","21.569","0.0002164","5.1643",46473000,2,"1.11849",1,"3.13508","2.3784","sp|Q13636|RAB31_HUMAN;tr|J3QR51|J3QR51_HUMAN","sp|Q13636|RAB31_HUMAN;tr|J3QR51|J3QR51_HUMAN",2399,"Q13636","RAB31_HUMAN","Ras-related protein Rab-31",null,"RAB31"]
["16.1602","11.745","15.7538","18.1665",1,"15.6697",{"$nulls":3},"signal transduction",null,"cytosol;perinuclear region of cytoplasm",{"$nulls":3},6,6,6,13,13,13,"76.992",0,"11.508",43229000,8,"0.2052",1,"2.94092","0.531137","sp|Q8IUC4|RHPN2_HUMAN;sp|A8MT19|RHN2P_HUMAN","sp|Q8IUC4|RHPN2_HUMAN",3275,"Q8IUC4","RHPN2_HUMAN","Rhophilin-2",null,"RHPN2"]
["20.1683","18.766","20.0487","18.3894","14.8719","17.6662",{"$nulls":3},"antimicrobial humoral response;cell morphogenesis;central nervous system myelin maintenance;chaperone-mediated protein complex assembly;chaperone-mediated protein folding;chaperone-mediated protein transport involved in chaperone-mediated autophagy;complement activation;complement activation, classical pathway;innate immune response;intrinsic apoptotic signaling pathway;lipid metabolic process;microglial cell activation;microglial cell proliferation;negative regulation of amyloid fibril formation;negative regulation of amyloid-beta formation;negative regulation of cell death;negative regulation of cellular response to thapsigargin;negative regulation of cellular response to tunicamycin;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of protein homooligomerization;negative regulation of release of cytochrome c from mitochondria;negative regulation of response to endoplasmic reticulum stress;platelet degranulation;positive regulation of amyloid fibril formation;positive regulation of amyloid-beta formation;positive regulation of apoptotic process;positive regulation of gene expression;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of neurofibrillary tangle assembly;positive regulation of neuron death;positive regulation of NF-kappaB transcription factor activity;positive regulation of nitric oxide biosynthetic process;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein homooligomerization;positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;positive regulation of receptor-mediated endocytosis;positive regulation of tau-protein kinase activity;positive regulation of tumor necrosis factor production;protein import;protein stabilization;protein targeting to lysosome involved in chaperone-mediated autophagy;regulation of amyloid-beta clearance;regulation of complement activation;regulation of neuron death;regulation of neuronal signal transduction;release of cytochrome c from mitochondria;response to misfolded protein;response to virus;reverse cholesterol transport","amyloid-beta binding;chaperone binding;low-density lipoprotein particle receptor binding;misfolded protein binding;protein complex binding;ubiquitin protein ligase binding","apical dendrite;blood microparticle;cell surface;chromaffin granule;cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;extracellular matrix;extracellular region;extracellular space;Golgi apparatus;intracellular;mitochondrial membrane;mitochondrion;neurofibrillary tangle;nucleus;perinuclear region of cytoplasm;platelet alpha granule lumen;protein complex;spherical high-density lipoprotein particle","Complement and coagulation cascades",null,null,5,5,5,"16.9","16.9","16.9","52.494",0,"19.259",111170000,13,"1.08584",1,"2.68521","2.30963","sp|P10909|CLUS_HUMAN;tr|H0YAS8|H0YAS8_HUMAN;tr|H0YC35|H0YC35_HUMAN;tr|E7ERK6|E7ERK6_HUMAN;tr|H0YLK8|H0YLK8_HUMAN","sp|P10909|CLUS_HUMAN;tr|H0YAS8|H0YAS8_HUMAN;tr|H0YC35|H0YC35_HUMAN",1030,"P10909","CLUS_HUMAN","Clusterin",null,"CLU"]
["22.9532","21.0376",1,1,"18.368","17.6484",{"$nulls":3},"cellular respiration;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;response to drug;response to hydroperoxide;response to organic cyclic compound","NADH dehydrogenase (ubiquinone) activity","dendrite;integral component of membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial respiratory chain complex I;neuronal cell body","Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,2,2,2,"8.5","8.5","8.5","35.66",0,"32.816",92478000,6,"0.106221",1,"2.65812","0.294494","sp|P03886|NU1M_HUMAN","sp|P03886|NU1M_HUMAN",857,"P03886","NU1M_HUMAN","NADH-ubiquinone oxidoreductase chain 1",null,"MT-ND1"]
["20.2042","18.9195","19.8764","17.1129","16.79","17.1493",{"$nulls":3},"apoptotic DNA fragmentation;DNA metabolic process;erythrocyte differentiation","deoxyribonuclease II activity;DNA binding","extracellular exosome;intracellular;lysosome","Lysosome",null,null,4,4,4,"17.5","17.5","17.5","39.58",0,"9.0516",64232000,6,"2.56162",1,"2.64931","6.59139","sp|O00115|DNS2A_HUMAN;tr|K7ENE5|K7ENE5_HUMAN","sp|O00115|DNS2A_HUMAN;tr|K7ENE5|K7ENE5_HUMAN",198,"O00115","DNS2A_HUMAN","Deoxyribonuclease-2-alpha",null,"DNASE2"]
["24.9618","21.0217","23.9334","19.5051","19.0684","23.5702",{"$nulls":3},"histone H3-K27 trimethylation;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;nucleosome assembly;nucleosome positioning","ADP binding;AMP binding;ATP binding;calcium ion binding;chromatin DNA binding;dATP binding;double-stranded DNA binding;GTP binding;RNA binding","extracellular exosome;nuclear heterochromatin;nuclear nucleosome;nucleus",{"$nulls":3},7,1,1,"26.5","7.3","7.3","21.865",0,"9.0386",3462200000,15,"0.628356",1,"2.59104","1.39563","sp|P10412|H14_HUMAN;sp|P16402|H13_HUMAN;sp|P22492|H1T_HUMAN;sp|Q02539|H11_HUMAN;sp|P16401|H15_HUMAN","sp|P10412|H14_HUMAN;sp|P16402|H13_HUMAN",1017,"P10412","H14_HUMAN","Histone H1.4",null,"HIST1H1E"]
["21.5709","20.9526","21.2066","19.0589","18.4936","18.8804",{"$nulls":3},"chromatin silencing;covalent chromatin modification;dosage compensation;establishment of protein localization to chromatin;negative regulation of cell cycle G2/M phase transition;negative regulation of gene expression, epigenetic;negative regulation of histone H3-K27 methylation;negative regulation of histone H3-K4 methylation;negative regulation of histone phosphorylation;negative regulation of protein localization to chromosome, telomeric region;negative regulation of protein serine/threonine kinase activity;negative regulation of response to oxidative stress;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;nucleosome assembly;positive regulation of gene expression, epigenetic;positive regulation of keratinocyte differentiation;positive regulation of maintenance of mitotic sister chromatid cohesion;positive regulation of response to oxidative stress;regulation of gene expression, epigenetic;regulation of lipid metabolic process;regulation of response to oxidative stress","chromatin DNA binding;core promoter sequence-specific DNA binding;DNA binding;double-stranded methylated DNA binding;enzyme binding;nucleosomal DNA binding;protein heterodimerization activity;protein kinase binding;protein serine/threonine kinase inhibitor activity;rDNA binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription regulatory region DNA binding","Barr body;condensed chromosome;extracellular exosome;nuclear chromatin;nuclear chromosome;nuclear chromosome, telomeric region;nucleolus;nucleosome;nucleus;pericentric heterochromatin;sex chromatin","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,12,12,10,43,43,36,"39.617",0,"80.332",872350000,108,"3.23787",1,"2.43237","9.92656","sp|O75367|H2AY_HUMAN;tr|B4DJC3|B4DJC3_HUMAN;tr|D6RCF2|D6RCF2_HUMAN","sp|O75367|H2AY_HUMAN;tr|B4DJC3|B4DJC3_HUMAN",573,"O75367","H2AY_HUMAN","Core histone macro-H2A.1","H2A1;istone macroH2A1","H2AFY"]
["20.1127","20.2243","20.0126","17.5156","15.975","19.5914",{"$nulls":3},"antigen processing and presentation of endogenous peptide antigen via MHC class I",null,"integral component of membrane",{"$nulls":3},3,3,3,"7.4","7.4","7.4","47.606",0,"7.4275",89616000,9,"1.08516",1,"2.42258","2.30821","tr|A0A0G2JKZ1|A0A0G2JKZ1_HUMAN;sp|O15533|TPSN_HUMAN;tr|A2AB90|A2AB90_HUMAN;tr|A0A0G2JH37|A0A0G2JH37_HUMAN;tr|A0A0A0MSV9|A0A0A0MSV9_HUMAN;tr|Q6P1N7|Q6P1N7_HUMAN;tr|C9JA35|C9JA35_HUMAN;tr|A0A0A0MT98|A0A0A0MT98_HUMAN","tr|A0A0G2JKZ1|A0A0G2JKZ1_HUMAN;sp|O15533|TPSN_HUMAN;tr|A2AB90|A2AB90_HUMAN;tr|A0A0G2JH37|A0A0G2JH37_HUMAN;tr|A0A0A0MSV9|A0A0A0MSV9_HUMAN;tr|Q6P1N7|Q6P1N7_HUMAN;tr|C9JA35|C9JA35_HUMAN",384,"A0A0G2JKZ1","A0A0G2JKZ1_HUMAN",null,null,"TAPBP"]
["19.3901",1,"19.6924","14.3026",1,"17.5812",{"$nulls":3},"proteolysis involved in cellular protein catabolic process","serine-type carboxypeptidase activity","extracellular exosome",{"$nulls":3},6,6,6,"15.1","15.1","15.1","54.163",0,"17.935",54619000,9,"0.108461",1,"2.3996","0.300166","sp|Q9H3G5|CPVL_HUMAN;tr|H7C0X5|H7C0X5_HUMAN;tr|A0A087WVP6|A0A087WVP6_HUMAN;tr|H7C218|H7C218_HUMAN;tr|A0A087WXJ9|A0A087WXJ9_HUMAN;tr|C9JLV0|C9JLV0_HUMAN;tr|C9J6L4|C9J6L4_HUMAN;tr|C9JI22|C9JI22_HUMAN","sp|Q9H3G5|CPVL_HUMAN;tr|H7C0X5|H7C0X5_HUMAN;tr|A0A087WVP6|A0A087WVP6_HUMAN",4443,"Q9H3G5","CPVL_HUMAN","Probable serine carboxypeptidase CPVL",null,"CPVL"]
["25.2993","21.7551","20.6084","21.1699","21.5071","18.0916",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of protein kinase activity;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational elongation;translational initiation;viral transcription","protein kinase activator activity;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion","Ribosome",null,null,3,3,3,"74.6","74.6","74.6","11.514",0,"32.066",207120000,5,"0.574106",1,"2.29807","1.28986","sp|P05386|RLA1_HUMAN","sp|P05386|RLA1_HUMAN",901,"P05386","RLA1_HUMAN","60S acidic ribosomal protein P1",null,"RPLP1"]
["29.9701","28.5271","28.2377","27.0452","26.3196","26.5838",{"$nulls":3},"chromatin silencing","DNA binding;protein heterodimerization activity","extracellular exosome;nuclear chromatin;nucleosome;nucleus","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,6,6,1,55,55,"22.5","13.988",0,"188.2",51158000000,334,"1.76541",1,"2.26211","3.92586","sp|Q16777|H2A2C_HUMAN;sp|Q6FI13|H2A2A_HUMAN;sp|Q96QV6|H2A1A_HUMAN;REV__tr|H0Y672|H0Y672_HUMAN;REV__tr|E7EQ67|E7EQ67_HUMAN;REV__tr|H7BY63|H7BY63_HUMAN","sp|Q16777|H2A2C_HUMAN;sp|Q6FI13|H2A2A_HUMAN;sp|Q96QV6|H2A1A_HUMAN",2695,"Q16777","H2A2C_HUMAN","Histone H2A type 2-C",null,"HIST2H2AC"]
["22.4225","18.5126","21.7509","19.7052","15.3529","20.9836",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome","Ribosome",null,null,3,3,3,"19.1","19.1","19.1","21.405",0,"71.999",151790000,15,"0.457551",1,"2.21479","1.06052","sp|Q9BYC8|RM32_HUMAN","sp|Q9BYC8|RM32_HUMAN",4308,"Q9BYC8","RM32_HUMAN","39S ribosomal protein L32, mitochondrial","32mt;RP-L32","MRPL32"]
["20.4389","18.5604","19.7007","15.9336","16.9353","19.2623",{"$nulls":3},"aging;ATP-dependent chromatin remodeling;cellular protein complex assembly;cellular response to organic cyclic compound;chromatin silencing at rDNA;embryonic organ development;heart development;maternal behavior;methylation-dependent chromatin silencing;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of chromatin binding;positive regulation of Wnt signaling pathway;regulation of cell proliferation;regulation of DNA methylation;response to estradiol;response to mechanical stimulus;response to nutrient levels;transcription, DNA-templated","C2H2 zinc finger domain binding;chromatin binding;methyl-CpG binding;mRNA binding;protein domain specific binding;satellite DNA binding;siRNA binding","cytosol;heterochromatin;histone deacetylase complex;nuclear chromatin;nucleoplasm;nucleus;protein complex",{"$nulls":3},7,7,7,"25.1","25.1","25.1","43.254",0,"51.616",160020000,22,"0.906471",1,"2.18962","1.94243","sp|Q9UBB5|MBD2_HUMAN;tr|X6RBL6|X6RBL6_HUMAN","sp|Q9UBB5|MBD2_HUMAN",4947,"Q9UBB5","MBD2_HUMAN","Methyl-CpG-binding domain protein 2",null,"MBD2"]
["16.5227","17.4276","17.3052","15.5019","14.1477","15.1272",{"$nulls":3},"attachment of mitotic spindle microtubules to kinetochore;protein localization to kinetochore;protein localization to microtubule;sister chromatid biorientation","metal ion binding;nucleic acid binding","condensed chromosome;condensed chromosome kinetochore;cytoplasm;nuclear body;nucleoplasm;nucleus;spindle",{"$nulls":3},11,11,11,17,17,17,"89.098",0,"35.168",255950000,30,"1.92466",1,"2.15956","4.37792","sp|Q96JM3|CHAP1_HUMAN;tr|S4R3K0|S4R3K0_HUMAN","sp|Q96JM3|CHAP1_HUMAN",3942,"Q96JM3","CHAP1_HUMAN","Chromosome alignment-maintaining phosphoprotein 1",null,"CHAMP1"]
["20.7534","17.9882","18.5291","16.2418","17.0159","17.5702",{"$nulls":3},"glomerular filtration;protein processing","aminopeptidase activity;manganese ion binding;metallopeptidase activity","extracellular exosome;mitochondrion",{"$nulls":3},5,5,5,"16.4","16.4","16.4","57.033",0,"32.828",95459000,8,"1.08603",1,"2.14759","2.31004","sp|Q9NQH7|XPP3_HUMAN","sp|Q9NQH7|XPP3_HUMAN",4656,"Q9NQH7","XPP3_HUMAN","Probable Xaa-Pro aminopeptidase 3","-Pro aminopeptidase 3","XPNPEP3"]
["19.0787","18.2544","18.7099","16.3152","14.5548","18.7354",{"$nulls":3},"endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA processing","endoribonuclease activity","nucleolus;nucleoplasm","Ribosome biogenesis in eukaryotes",null,null,5,5,5,"16.6","16.6","16.6","40.842",0,"13.344",149140000,27,"0.80327",1,"2.14589","1.73748","sp|Q9Y2P8|RCL1_HUMAN;tr|Q5VZU3|Q5VZU3_HUMAN;tr|Q5VZU2|Q5VZU2_HUMAN;tr|Q5VYW8|Q5VYW8_HUMAN","sp|Q9Y2P8|RCL1_HUMAN",5231,"Q9Y2P8","RCL1_HUMAN","RNA 3'-terminal phosphate cyclase-like protein",null,"RCL1"]
["16.1038","15.9296","15.4397","13.0548","13.2968","14.7233",{"$nulls":3},"angiogenesis","ATPase activity;metal ion binding;ubiquitin-protein transferase activity","cytosol;nucleolus",{"$nulls":3},17,17,17,"4.2","4.2","4.2","591.4",0,"36.197",130050000,22,"1.72915",1,"2.13275","3.82754","tr|A0A0A0MTR7|A0A0A0MTR7_HUMAN;sp|Q63HN8|RN213_HUMAN;tr|A0A0A0MTC1|A0A0A0MTC1_HUMAN","tr|A0A0A0MTR7|A0A0A0MTR7_HUMAN;sp|Q63HN8|RN213_HUMAN;tr|A0A0A0MTC1|A0A0A0MTC1_HUMAN",2919,"A0A0A0MTR7","A0A0A0MTR7_HUMAN",null,null,"RNF213"]
["21.0356","20.3317","20.9655","19.2652","18.827","17.9451",{"$nulls":3},"cell cycle;nucleobase-containing compound metabolic process;positive regulation of Notch signaling pathway;pyrimidine nucleoside metabolic process;pyrimidine nucleotide biosynthetic process","methyl-CpG binding;RNA binding","methylosome;midbody",{"$nulls":3},2,2,2,"21.2","21.2","21.2","12.259",0,"8.1375",64522000,5,"2.02559",1,"2.09849","4.68282","sp|P84090|ERH_HUMAN;tr|G3V279|G3V279_HUMAN","sp|P84090|ERH_HUMAN;tr|G3V279|G3V279_HUMAN",2097,"P84090","ERH_HUMAN","Enhancer of rudimentary homolog",null,"ERH"]
["21.0251","20.2179",1,1,"18.6448","16.3479",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"21.5","21.5","21.5","11.896","0.0013574","3.1666",53712000,3,"0.086208",1,"2.0834","0.242999","tr|B1AH87|B1AH87_HUMAN;sp|P30536|TSPOA_HUMAN","tr|B1AH87|B1AH87_HUMAN;sp|P30536|TSPOA_HUMAN",1389,"B1AH87","B1AH87_HUMAN",null,null,"TSPO"]
["19.9136","19.9034","18.683","16.9153","16.9164","18.5113",{"$nulls":3},"bone development;chaperone-mediated protein folding;collagen metabolic process;negative regulation of cell proliferation;negative regulation of post-translational protein modification;protein folding;protein hydroxylation;protein stabilization;regulation of protein secretion","iron ion binding;L-ascorbic acid binding;procollagen-proline 3-dioxygenase activity;protein complex binding","endoplasmic reticulum;endoplasmic reticulum lumen;extracellular exosome;macromolecular complex;membrane;proteinaceous extracellular matrix",{"$nulls":3},7,7,7,"10.7","10.7","10.7","83.393",0,"25.186",145440000,14,"1.42428",1,"2.05231","3.06035","sp|Q32P28|P3H1_HUMAN;tr|H7C2W6|H7C2W6_HUMAN;tr|E2QRI1|E2QRI1_HUMAN","sp|Q32P28|P3H1_HUMAN",2731,"Q32P28","P3H1_HUMAN","Prolyl 3-hydroxylase 1 {ECO:0000312|HGNC:HGNC:19316}",null,"P3H1"]
["20.9649","18.6381","19.5237","20.5329","17.4323","15.0285",{"$nulls":3},"transport",null,"endosome;endosome membrane;extracellular exosome;integral component of plasma membrane",{"$nulls":3},3,3,3,6,6,6,"75.775",0,"16.297",132370000,18,"0.518353",1,"2.04433","1.18067","sp|Q99805|TM9S2_HUMAN","sp|Q99805|TM9S2_HUMAN",4110,"Q99805","TM9S2_HUMAN","Transmembrane 9 superfamily member 2",null,"TM9SF2"]
["25.1622","23.4127","23.0095","22.0897","21.4292","21.9412",{"$nulls":3},"macroautophagy;protein import into mitochondrial matrix;protein import into mitochondrial outer membrane;protein targeting to mitochondrion","protein transmembrane transporter activity","integral component of membrane;integral component of mitochondrial outer membrane;membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrial outer membrane translocase complex",{"$nulls":3},6,6,6,"66.2","66.2","66.2","15.521",0,"158.69",579480000,44,"1.38015",1,"2.04145","2.95715","sp|Q9NS69|TOM22_HUMAN","sp|Q9NS69|TOM22_HUMAN",4708,"Q9NS69","TOM22_HUMAN","Mitochondrial import receptor subunit TOM22 homolog","Tom22","TOMM22"]
["21.2209","19.0193",1,"18.0131","16.1266",1,{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;metal ion binding;RNA binding","catalytic step 2 spliceosome;nuclear matrix;nuclear speck;nucleoplasm;precatalytic spliceosome;U12-type spliceosomal complex;U2 snRNP","Spliceosome",null,null,6,6,6,"55.5","55.5","55.5","12.405",0,"13.986",72883000,10,"0.0862177",1,"2.03348","0.243024","sp|Q7RTV0|PHF5A_HUMAN","sp|Q7RTV0|PHF5A_HUMAN",3140,"Q7RTV0","PHF5A_HUMAN","PHD finger-like domain-containing protein 5A","HD finger-like domain protein 5A","PHF5A"]
["21.8201","17.7839","20.1684","18.35","17.2162","18.1591",{"$nulls":3},"cellular response to leukemia inhibitory factor;glucosamine metabolic process;liver development;N-acetylglucosamine metabolic process;UDP-N-acetylglucosamine biosynthetic process","glucosamine 6-phosphate N-acetyltransferase activity;identical protein binding;monosaccharide binding","cytosol;endoplasmic reticulum-Golgi intermediate compartment;endosome membrane;Golgi membrane;late endosome","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,6,6,6,"56.5","56.5","56.5","20.749",0,"17.48",90725000,10,"0.757918",1,"2.01574","1.6484","sp|Q96EK6|GNA1_HUMAN;tr|G3V4W4|G3V4W4_HUMAN;tr|G3V5E4|G3V5E4_HUMAN","sp|Q96EK6|GNA1_HUMAN;tr|G3V4W4|G3V4W4_HUMAN;tr|G3V5E4|G3V5E4_HUMAN",3854,"Q96EK6","GNA1_HUMAN","Glucosamine 6-phosphate N-acetyltransferase",null,"GNPNAT1"]
["23.3203",1,"17.9842",1,"17.235","18.1844",{"$nulls":4},"hydrolase activity",{"$nulls":4},2,2,2,14,14,14,"25.029","0.0048381","2.5023",202220000,1,"0.0791454",1,"1.96169","0.224456","tr|F5GXT0|F5GXT0_HUMAN;tr|F8W7U8|F8W7U8_HUMAN;sp|P49959|MRE11_HUMAN;tr|F5H742|F5H742_HUMAN;tr|F5H256|F5H256_HUMAN","tr|F5GXT0|F5GXT0_HUMAN;tr|F8W7U8|F8W7U8_HUMAN;sp|P49959|MRE11_HUMAN;tr|F5H742|F5H742_HUMAN;tr|F5H256|F5H256_HUMAN",1697,"F5GXT0","F5GXT0_HUMAN",null,null,"MRE11"]
["18.7449","18.7225","17.9044","14.1713","18.0813","17.2475",{"$nulls":3},"cellular response to estradiol stimulus;RNA secondary structure unwinding","ATP binding;ATP-dependent RNA helicase activity;RNA binding","chromosome;cytoplasm;membrane;nucleolus",{"$nulls":3},17,17,17,"34.9","34.9","34.9","75.406",0,"93.908",1041300000,98,"0.734909",1,"1.95728","1.60337","sp|Q9NVP1|DDX18_HUMAN;tr|H7C452|H7C452_HUMAN","sp|Q9NVP1|DDX18_HUMAN",4769,"Q9NVP1","DDX18_HUMAN","ATP-dependent RNA helicase DDX18",null,"DDX18"]
["25.0574","22.6622","22.7512","21.2528","22.2362","21.1338",{"$nulls":3},"spliceosomal snRNP assembly",null,"spliceosomal complex",{"$nulls":3},3,3,3,"31.2","31.2","31.2","7.1013",0,"10.334",395040000,23,"1.06744",1,"1.94932","2.27118","tr|Q49AN9|Q49AN9_HUMAN;tr|F5H013|F5H013_HUMAN;sp|P62308|RUXG_HUMAN;sp|A8MWD9|RUXGL_HUMAN;tr|C9JVQ0|C9JVQ0_HUMAN","tr|Q49AN9|Q49AN9_HUMAN;tr|F5H013|F5H013_HUMAN;sp|P62308|RUXG_HUMAN;sp|A8MWD9|RUXGL_HUMAN",192,"Q49AN9","Q49AN9_HUMAN"]
["19.3094","17.1137","18.6041","17.5789","15.2347","16.4395",{"$nulls":3},"activation of innate immune response;apoptotic process;cellular response to exogenous dsRNA;cellular response to interferon-beta;cellular response to organic cyclic compound;defense response to virus;innate immune response;interferon-beta production;neutrophil degranulation;positive regulation of defense response to virus by host;positive regulation of protein binding;positive regulation of protein import into nucleus, translocation;positive regulation of transcription factor import into nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;regulation of type I interferon production;viral process","cyclic-di-GMP binding;cyclic-GMP-AMP binding;identical protein binding;protein homodimerization activity;protein kinase binding;transcription factor binding;ubiquitin protein ligase binding","cytoplasmic vesicle membrane;cytosol;endoplasmic reticulum membrane;Golgi apparatus;integral component of membrane;mitochondrial outer membrane;nucleoplasm;perinuclear region of cytoplasm;peroxisome;plasma membrane;secretory granule membrane","Cytosolic DNA-sensing pathway;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway",null,null,3,3,3,"12.4","12.4","12.4","42.192",0,"8.5495",31430000,2,"0.962479",1,"1.92471","2.05537","sp|Q86WV6|STING_HUMAN;tr|J3QTB1|J3QTB1_HUMAN","sp|Q86WV6|STING_HUMAN",3247,"Q86WV6","STING_HUMAN","Stimulator of interferon genes protein {ECO:0000303|PubMed:18724357}","STING {ECO:0000303|PubMed:18724357, ECO:0000303|PubMed:26669264}","TMEM173"]
["21.232","17.2627","19.9009","19.9465","13.1423","19.5437",{"$nulls":4},"RNA binding","cytosol;nucleoplasm",{"$nulls":3},9,6,2,"35.3","26.8","8.8","42.835",0,"19.067",145600000,18,"0.315115",1,"1.92105","0.770393","tr|F8W8I6|F8W8I6_HUMAN;sp|P31483|TIA1_HUMAN;tr|E5RGV5|E5RGV5_HUMAN;tr|E5RG67|E5RG67_HUMAN;tr|F8WE16|F8WE16_HUMAN","tr|F8W8I6|F8W8I6_HUMAN;sp|P31483|TIA1_HUMAN;tr|E5RGV5|E5RGV5_HUMAN",1406,"F8W8I6","F8W8I6_HUMAN",null,null,"TIA1"]
["20.9306","20.2008","21.9885","15.4021","20.1935","21.8108",{"$nulls":3},"fatty-acyl-CoA biosynthetic process;monounsaturated fatty acid biosynthetic process;unsaturated fatty acid biosynthetic process","metal ion binding;oxidoreductase activity;stearoyl-CoA 9-desaturase activity","endoplasmic reticulum membrane;integral component of membrane","AMPK signaling pathway;Biosynthesis of unsaturated fatty acids;Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway",null,null,5,5,5,"13.6","13.6","13.6","37.61",0,"89.848",604290000,24,"0.405192",1,"1.90452","0.955628","sp|Q86SK9|SCD5_HUMAN","sp|Q86SK9|SCD5_HUMAN",3203,"Q86SK9","SCD5_HUMAN","Stearoyl-CoA desaturase 5 {ECO:0000305}",null,"SCD5"]
["28.7408","28.5397","28.3186","26.8564","26.3343","26.7021",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular protein metabolic process;CENP-A containing nucleosome assembly;chromatin silencing at rDNA;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;DNA-templated transcription, initiation;double-strand break repair via nonhomologous end joining;negative regulation of gene expression, epigenetic;negative regulation of megakaryocyte differentiation;nucleosome assembly;positive regulation of gene expression, epigenetic;protein heterotetramerization;regulation of gene silencing by miRNA;regulation of hematopoietic stem cell differentiation;regulation of megakaryocyte differentiation;telomere capping;telomere organization","DNA binding;histone binding;protein domain specific binding;protein heterodimerization activity;RNA binding","extracellular exosome;extracellular matrix;extracellular region;membrane;nuclear chromosome;nuclear chromosome, telomeric region;nuclear nucleosome;nucleoplasm;nucleosome;nucleus;protein complex","Alcoholism;Systemic lupus erythematosus;Viral carcinogenesis",null,null,12,12,12,66,66,66,"11.367",0,"98.526",34093000000,508,"3.19041",1,"1.90208","9.64988","sp|P62805|H4_HUMAN","sp|P62805|H4_HUMAN",1991,"P62805","H4_HUMAN","Histone H4",null,"HIST1H4A;HIST1H4B;HIST1H4C;HIST1H4D;HIST1H4E;HIST1H4F;HIST1H4H;HIST1H4I;HIST1H4J;HIST1H4K;HIST1H4L;HIST2H4A;HIST2H4B;HIST4H4"]
["22.0739","20.858","19.3022","19.8568","18.1905","18.5568",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,3,3,3,"24.8","24.8","24.8","16.402",0,"11.31",72401000,8,"0.924805",1,"1.87667","1.97925","sp|P17568|NDUB7_HUMAN","sp|P17568|NDUB7_HUMAN",1158,"P17568","NDUB7_HUMAN","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7",null,"NDUFB7"]
["20.0886","18.6792","20.1017","15.0452","18.1981","20.0596",{"$nulls":3},"mitochondrial respiratory chain complex I assembly","oxidoreductase activity","integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion",{"$nulls":3},6,6,6,"16.9","16.9","16.9","53.811",0,"20.939",165890000,8,"0.53162",1,"1.85554","1.20672","sp|Q96CU9|FXRD1_HUMAN;tr|E9PP78|E9PP78_HUMAN","sp|Q96CU9|FXRD1_HUMAN",3830,"Q96CU9","FXRD1_HUMAN","FAD-dependent oxidoreductase domain-containing protein 1 {ECO:0000312|HGNC:HGNC:26927}",null,"FOXRED1"]
["21.6267","18.7204","19.6158","17.7975","17.351","19.2612",{"$nulls":3},"cristae formation",null,"extracellular exosome;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion",{"$nulls":3},12,12,12,"30.1","30.1","30.1","63.277",0,"224.14",584310000,61,"0.829092",1,"1.85105","1.78844","sp|Q9NVH1|DJC11_HUMAN;tr|B1AK20|B1AK20_HUMAN;tr|Q5TH61|Q5TH61_HUMAN","sp|Q9NVH1|DJC11_HUMAN;tr|B1AK20|B1AK20_HUMAN",4761,"Q9NVH1","DJC11_HUMAN","DnaJ homolog subfamily C member 11",null,"DNAJC11"]
["22.736","18.9735","20.2745","20.4182","16.8623","19.1744",{"$nulls":3},"protein methylation","methyltransferase activity",{"$nulls":4},11,2,2,"49.1","10.9","10.9","32.693",0,"52.773",250130000,22,"0.535628",1,"1.84302","1.21458","tr|A0A087X1W2|A0A087X1W2_HUMAN","tr|A0A087X1W2|A0A087X1W2_HUMAN",5440,"A0A087X1W2","A0A087X1W2_HUMAN",null,null,"PRMT1"]
["18.9989","17.2928","18.6946","17.3202","16.08","16.1217",{"$nulls":3},"anatomical structure morphogenesis;angiogenesis;cell adhesion;glomerular filtration;positive regulation of cell migration;vascular wound healing",null,"external side of plasma membrane;extracellular region;extracellular space;focal adhesion;integral component of membrane;nucleus;plasma membrane",{"$nulls":3},10,10,10,"17.8","17.8","17.8","71.607",0,"55.404",145710000,20,"1.28559",1,"1.8215","2.74181","sp|P43121|MUC18_HUMAN","sp|P43121|MUC18_HUMAN",1566,"P43121","MUC18_HUMAN","Cell surface glycoprotein MUC18",null,"MCAM"]
["23.0029","20.5625","21.7881","19.054","20.0684","20.8592",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion",{"$nulls":3},3,3,3,"28.3","28.3","28.3","12.629",0,"10.139",154090000,21,"0.955693",1,"1.79062","2.04161","sp|Q9Y291|RT33_HUMAN;tr|C9JBY7|C9JBY7_HUMAN","sp|Q9Y291|RT33_HUMAN;tr|C9JBY7|C9JBY7_HUMAN",5213,"Q9Y291","RT33_HUMAN","28S ribosomal protein S33, mitochondrial","33mt;RP-S33","MRPS33"]
["23.0642","21.2393","21.186","20.7484","18.8027","20.6077",{"$nulls":3},"glutathione derivative biosynthetic process;leukotriene biosynthetic process;lipid metabolic process;response to organonitrogen compound;xenobiotic metabolic process","glutathione peroxidase activity;glutathione transferase activity;leukotriene-C4 synthase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;intracellular membrane-bounded organelle;membrane;nuclear envelope;organelle membrane","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Fluid shear stress and atherosclerosis;Glutathione metabolism;Hepatocellular carcinoma;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pathways in cancer;Platinum drug resistance",null,null,4,4,4,"32.9","32.9","32.9","16.516",0,"23.161",330780000,27,"0.945181",1,"1.77695","2.02034","sp|O14880|MGST3_HUMAN;tr|Q5VV89|Q5VV89_HUMAN;tr|Q5VV87|Q5VV87_HUMAN","sp|O14880|MGST3_HUMAN;tr|Q5VV89|Q5VV89_HUMAN;tr|Q5VV87|Q5VV87_HUMAN",303,"O14880","MGST3_HUMAN","Microsomal glutathione S-transferase 3","icrosomal GST-3","MGST3"]
["21.2066","19.651","19.5087","17.7163","19.1676","18.1653",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process",null,"mitochondrion",{"$nulls":3},2,2,2,"18.1","18.1","18.1","18.919",0,"8.0735",48633000,3,"1.20263",1,"1.77234","2.55885","tr|A0A024RBT2|A0A024RBT2_HUMAN;sp|Q9NR28|DBLOH_HUMAN;tr|F5GXT8|F5GXT8_HUMAN;tr|F5H796|F5H796_HUMAN","tr|A0A024RBT2|A0A024RBT2_HUMAN;sp|Q9NR28|DBLOH_HUMAN;tr|F5GXT8|F5GXT8_HUMAN;tr|F5H796|F5H796_HUMAN",4675,"A0A024RBT2","A0A024RBT2_HUMAN",null,null,"DIABLO"]
["28.7819","27.4114","26.6147","27.0433","25.2889","25.1816",{"$nulls":3},"antibacterial humoral response;antimicrobial humoral immune response mediated by antimicrobial peptide;defense response to Gram-positive bacterium;innate immune response in mucosa","DNA binding;protein heterodimerization activity","cytosol;extracellular space;nucleoplasm;nucleosome",{"$nulls":3},8,8,2,"53.2","53.2","7.9","13.906",0,"155.36",31360000000,370,"0.944025",1,"1.76473","2.018","tr|B2R4S9|B2R4S9_HUMAN;sp|Q99880|H2B1L_HUMAN;sp|Q99879|H2B1M_HUMAN;sp|Q99877|H2B1N_HUMAN;sp|Q93079|H2B1H_HUMAN;sp|Q5QNW6|H2B2F_HUMAN;sp|P62807|H2B1C_HUMAN;sp|P58876|H2B1D_HUMAN;sp|P57053|H2BFS_HUMAN;sp|O60814|H2B1K_HUMAN;tr|U3KQK0|U3KQK0_HUMAN","tr|B2R4S9|B2R4S9_HUMAN;sp|Q99880|H2B1L_HUMAN;sp|Q99879|H2B1M_HUMAN;sp|Q99877|H2B1N_HUMAN;sp|Q93079|H2B1H_HUMAN;sp|Q5QNW6|H2B2F_HUMAN;sp|P62807|H2B1C_HUMAN;sp|P58876|H2B1D_HUMAN;sp|P57053|H2BFS_HUMAN;sp|O60814|H2B1K_HUMAN;tr|U3KQK0|U3KQK0_HUMAN",524,"B2R4S9","B2R4S9_HUMAN","Histone H2B {ECO:0000256|RuleBase:RU000451}",null,"HIST1H2BC"]
["23.4086",1,"23.7399","18.1885",1,"23.6695",{"$nulls":3},"negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;positive regulation of transcription from RNA polymerase II promoter;ribosomal large subunit export from nucleus;transcription, DNA-templated","DNA binding;ribosomal large subunit binding;zinc ion binding","nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},5,5,5,53,53,53,"15.199",0,"11.279",420740000,18,"0.0601534",1,"1.76348","0.173539","sp|O00488|ZN593_HUMAN;tr|A9J4F5|A9J4F5_HUMAN","sp|O00488|ZN593_HUMAN;tr|A9J4F5|A9J4F5_HUMAN",247,"O00488","ZN593_HUMAN","Zinc finger protein 593",null,"ZNF593"]
["19.6406","14.5804","18.6218","16.7713","14.4551","16.3736",{"$nulls":3},"cell proliferation;endocytosis;lipid tube assembly;membrane organization;muscle cell differentiation;nucleus localization;nucleus organization;positive regulation of apoptotic process;positive regulation of astrocyte differentiation;regulation of cell cycle arrest;regulation of endocytosis;regulation of neuron differentiation;viral process","actin filament binding;identical protein binding;RNA polymerase binding;tau protein binding","actin cytoskeleton;axon;axon initial segment;cytoplasm;cytosol;I band;lipid tube;membrane;node of Ranvier;nuclear envelope;T-tubule;Z disc","Endocytosis;Fc gamma R-mediated phagocytosis",null,null,3,3,3,"9.6","9.6","9.6","64.699",0,"17.04",88470000,6,"0.440432",1,"1.74757","1.0264","sp|O00499|BIN1_HUMAN","sp|O00499|BIN1_HUMAN",248,"O00499","BIN1_HUMAN","Myc box-dependent-interacting protein 1",null,"BIN1"]
["18.302",1,"18.0487","17.6209",1,"13.5234",{"$nulls":4},"NADPH-adrenodoxin reductase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},29,1,0,"67.2","4.9",0,"53.808",0,"6.8159",24330000,2,"0.0806092",1,"1.73543","0.228315","tr|A0A0C4DFN8|A0A0C4DFN8_HUMAN;tr|A0A0A0MSZ4|A0A0A0MSZ4_HUMAN;tr|A0A0A0MTR6|A0A0A0MTR6_HUMAN;tr|A0A0C4DGN7|A0A0C4DGN7_HUMAN;tr|A0A0A0MT64|A0A0A0MT64_HUMAN;tr|A0A0A0MTN9|A0A0A0MTN9_HUMAN;tr|J3QKZ8|J3QKZ8_HUMAN;tr|J3QQW7|J3QQW7_HUMAN","tr|A0A0C4DFN8|A0A0C4DFN8_HUMAN;tr|A0A0A0MSZ4|A0A0A0MSZ4_HUMAN;tr|A0A0A0MTR6|A0A0A0MTR6_HUMAN;tr|A0A0C4DGN7|A0A0C4DGN7_HUMAN;tr|A0A0A0MT64|A0A0A0MT64_HUMAN;tr|A0A0A0MTN9|A0A0A0MTN9_HUMAN",5450,"A0A0C4DFN8","A0A0C4DFN8_HUMAN","NADPH:adrenodoxin oxidoreductase, mitochondrial {ECO:0000256|PIRNR:PIRNR000362}",null,"FDXR"]
["19.1812","18.1175","16.7333","15.9328","16.6913","16.2132",{"$nulls":3},"cellular response to DNA damage stimulus;negative regulation of cell growth;positive regulation of cell growth;positive regulation of signal transduction;regulation of protein stability","p53 binding;RNA binding","granular component;nucleolus;nucleoplasm",{"$nulls":3},9,9,9,"24.8","24.8","24.8","61.124",0,"36.145",101670000,21,"1.09664",1,"1.73159","2.33231","sp|Q9NXV6|CARF_HUMAN;tr|J3KNE1|J3KNE1_HUMAN;tr|D6RGD2|D6RGD2_HUMAN","sp|Q9NXV6|CARF_HUMAN",4837,"Q9NXV6","CARF_HUMAN","CDKN2A-interacting protein",null,"CDKN2AIP"]
["18.173","16.1222","16.5827","17.0382","14.4969","14.1618",{"$nulls":3},"artery development;neural fold bending;ventricular septum development",null,"extracellular exosome;membrane;nucleus",{"$nulls":3},17,17,17,"21.2","21.2","21.2","120.27",0,"40.31",130550000,26,"0.717616",1,"1.72699","1.56959","sp|Q86V48|LUZP1_HUMAN;tr|E5RFK8|E5RFK8_HUMAN;tr|E5RHU7|E5RHU7_HUMAN","sp|Q86V48|LUZP1_HUMAN",3227,"Q86V48","LUZP1_HUMAN","Leucine zipper protein 1",null,"LUZP1"]
["24.6607","22.3569","22.8349","22.4576","20.5496","21.6917",{"$nulls":3},"regulation of transcription, DNA-templated;response to hypoxia;response to oxidative stress","cadherin binding involved in cell-cell adhesion;metal ion binding;transcription coactivator activity","cell-cell adherens junction;cytoskeleton;focal adhesion;transcription factor complex;Z disc",{"$nulls":3},13,13,13,"61.1","61.1","61.1","36.071",0,"323.31",1596500000,60,"0.89552",1,"1.71785","1.9205","sp|O00151|PDLI1_HUMAN","sp|O00151|PDLI1_HUMAN",203,"O00151","PDLI1_HUMAN","PDZ and LIM domain protein 1",null,"PDLIM1"]
["23.9932","22.1897","22.8025","21.4471","20.3875","22.0144",{"$nulls":5},"nucleus",{"$nulls":3},6,5,5,"49.1","39.9","39.9","20.03",0,"113.44",480630000,35,"1.13017",1,"1.71214","2.40315","tr|J3KS05|J3KS05_HUMAN;sp|P83916|CBX1_HUMAN;tr|B5MD17|B5MD17_HUMAN;tr|K7ELA4|K7ELA4_HUMAN;tr|C9JWS9|C9JWS9_HUMAN","tr|J3KS05|J3KS05_HUMAN;sp|P83916|CBX1_HUMAN;tr|B5MD17|B5MD17_HUMAN;tr|K7ELA4|K7ELA4_HUMAN;tr|C9JWS9|C9JWS9_HUMAN",2093,"J3KS05","J3KS05_HUMAN",null,null,"CBX1"]
["21.2146","16.1937",1,1,"15.79","16.4968",{"$nulls":3},"angiogenesis;negative regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;viral genome replication","DNA binding;DNA binding transcription factor activity;sequence-specific DNA binding;transcription corepressor activity","cytosol;nucleoplasm;nucleus",{"$nulls":3},6,5,5,"13.7","10.4","10.4","60.49",0,"9.6147",3477000000,8,"0.0759627",1,"1.70719","0.216032","sp|Q9NZI7|UBIP1_HUMAN;tr|C9JWL3|C9JWL3_HUMAN;tr|F8WEP8|F8WEP8_HUMAN","sp|Q9NZI7|UBIP1_HUMAN;tr|C9JWL3|C9JWL3_HUMAN",4874,"Q9NZI7","UBIP1_HUMAN","Upstream-binding protein 1",null,"UBP1"]
["24.5179","22.9414","23.5331","22.8825","21.3919","21.6416",{"$nulls":4},"RNA binding","intracellular ribonucleoprotein complex;viral nucleocapsid",{"$nulls":3},11,11,1,"45.2","45.2","6.2","31.948",0,"126.42",1773500000,101,"1.22114",1,"1.69214","2.59921","tr|B2R5W2|B2R5W2_HUMAN;tr|G3V4C1|G3V4C1_HUMAN;tr|G3V4W0|G3V4W0_HUMAN;tr|B4DY08|B4DY08_HUMAN;tr|G3V5X6|G3V5X6_HUMAN;tr|G3V3K6|G3V3K6_HUMAN;tr|G3V251|G3V251_HUMAN;tr|G3V2D6|G3V2D6_HUMAN;tr|B4DSU6|B4DSU6_HUMAN;tr|G3V5V7|G3V5V7_HUMAN;tr|A0A0G2JPF8|A0A0G2JPF8_HUMAN;tr|A0A0G2JNQ3|A0A0G2JNQ3_HUMAN;sp|P0DMR1|HNRC4_HUMAN;sp|O60812|HNRC1_HUMAN;sp|B7ZW38|HNRC3_HUMAN;sp|B2RXH8|HNRC2_HUMAN;tr|G3V4M8|G3V4M8_HUMAN;tr|G3V2H6|G3V2H6_HUMAN","tr|B2R5W2|B2R5W2_HUMAN;tr|G3V4C1|G3V4C1_HUMAN;tr|G3V4W0|G3V4W0_HUMAN;tr|B4DY08|B4DY08_HUMAN;tr|G3V5X6|G3V5X6_HUMAN;tr|G3V3K6|G3V3K6_HUMAN;tr|G3V251|G3V251_HUMAN;tr|G3V2D6|G3V2D6_HUMAN",5476,"B2R5W2","B2R5W2_HUMAN",null,null,"HNRNPC"]
["19.2088","17.9047","18.0241","19.124","13.386","17.599",{"$nulls":3},"cellular response to oxidative stress;peptidyl-serine phosphorylation;protein autophosphorylation;protein phosphorylation;regulation of cell shape;regulation of interleukin-1-mediated signaling pathway;regulation of MAPK cascade;viral process","ATP binding;protein domain specific binding;protein kinase binding;protein serine/threonine kinase activity","cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;mitochondrial membrane;nucleus;protein complex",{"$nulls":3},14,14,14,"38.6","38.6","38.6","58.14",0,"56.305",348710000,52,"0.402055",1,"1.67616","0.94929","sp|Q86Y07|VRK2_HUMAN;tr|E7ERS5|E7ERS5_HUMAN;tr|E9PBU1|E9PBU1_HUMAN","sp|Q86Y07|VRK2_HUMAN",3261,"Q86Y07","VRK2_HUMAN","Serine/threonine-protein kinase VRK2",null,"VRK2"]
["23.8505","20.8398","21.6104","20.53","19.8515","20.9079",{"$nulls":3},"oocyte maturation;spindle assembly involved in female meiosis","GTP binding;GTPase activity;structural constituent of cytoskeleton","cytoplasm;extracellular exosome;meiotic spindle;microtubule;microtubule cytoskeleton","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,9,1,1,"24.3","7.2","7.2","49.775",0,"171.77",633070000,23,"0.809765",1,"1.67043","1.75028","sp|Q3ZCM7|TBB8_HUMAN;tr|A0A075B736|A0A075B736_HUMAN;tr|Q5SQY0|Q5SQY0_HUMAN","sp|Q3ZCM7|TBB8_HUMAN;tr|A0A075B736|A0A075B736_HUMAN;tr|Q5SQY0|Q5SQY0_HUMAN",2745,"Q3ZCM7","TBB8_HUMAN","Tubulin beta-8 chain {ECO:0000305}",null,"TUBB8"]
["21.2258","19.0501","19.4423","18.9896","18.2406","17.4852",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;RNA export from nucleus;RNA splicing;RNA splicing, via transesterification reactions;termination of RNA polymerase II transcription","DNA binding;RNA binding","catalytic step 2 spliceosome;cytosol;nuclear matrix;nuclear speck;nucleoplasm;nucleus","mRNA surveillance pathway;RNA transport",null,null,18,18,18,23,23,23,"102.33",0,"209.31",2014700000,124,"0.979392",1,"1.66764","2.08976","sp|Q8IYB3|SRRM1_HUMAN;tr|A9Z1X7|A9Z1X7_HUMAN;tr|E9PCT1|E9PCT1_HUMAN;tr|M0R088|M0R088_HUMAN;tr|M0R1E7|M0R1E7_HUMAN;tr|M0QXG5|M0QXG5_HUMAN","sp|Q8IYB3|SRRM1_HUMAN;tr|A9Z1X7|A9Z1X7_HUMAN;tr|E9PCT1|E9PCT1_HUMAN;tr|M0R088|M0R088_HUMAN",3336,"Q8IYB3","SRRM1_HUMAN","Serine/arginine repetitive matrix protein 1",null,"SRRM1"]
["24.0008","23.1619","20.5835","20.5208","22.0554","20.1749",{"$nulls":3},"ATP-dependent chromatin remodeling;cell junction assembly;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component;negative regulation of protein binding;platelet aggregation;positive regulation of gene expression, epigenetic;postsynaptic actin cytoskeleton organization;protein deubiquitination;retina homeostasis;substantia nigra development;vascular endothelial growth factor receptor signaling pathway","ATP binding;identical protein binding;kinesin binding;nitric-oxide synthase binding;structural constituent of cytoskeleton;structural constituent of postsynaptic actin cytoskeleton;Tat protein binding","actin cytoskeleton;blood microparticle;cortical cytoskeleton;cytoplasm;cytoplasmic ribonucleoprotein granule;cytoskeleton;cytosol;dense body;extracellular exosome;extracellular space;focal adhesion;intracellular ribonucleoprotein complex;membrane;myelin sheath;NuA4 histone acetyltransferase complex;nuclear chromatin;nucleoplasm;nucleus;plasma membrane;protein complex;vesicle","Adherens junction;Apoptosis;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Dilated cardiomyopathy (DCM);Fluid shear stress and atherosclerosis;Focal adhesion;Gastric acid secretion;Hepatocellular carcinoma;Hippo signaling pathway;Hypertrophic cardiomyopathy (HCM);Influenza A;Leukocyte transendothelial migration;Oxytocin signaling pathway;Pathogenic Escherichia coli infection;Phagosome;Platelet activation;Proteoglycans in cancer;Rap1 signaling pathway;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis;Thermogenesis;Thyroid hormone signaling pathway;Tight junction;Vibrio cholerae infection;Viral myocarditis;Yersinia infection",null,null,29,1,1,"81.3","4.5","4.5","41.736",0,"86.086",1366500000,32,"0.636617",1,"1.66507","1.41172","sp|P60709|ACTB_HUMAN;tr|G5E9R0|G5E9R0_HUMAN;tr|E7EVS6|E7EVS6_HUMAN;tr|C9JZR7|C9JZR7_HUMAN;tr|C9JTX5|C9JTX5_HUMAN","sp|P60709|ACTB_HUMAN",1897,"P60709","ACTB_HUMAN","Actin, cytoplasmic 1",null,"ACTB"]
["17.6103","19.251","16.2208","14.4605","15.1686","18.5347",{"$nulls":3},"angiogenesis involved in wound healing;cell-matrix adhesion;glycosaminoglycan catabolic process;heparan sulfate proteoglycan catabolic process;neutrophil degranulation;positive regulation of blood coagulation;positive regulation of hair follicle development;positive regulation of osteoblast proliferation;positive regulation of protein kinase B signaling;positive regulation of vascular endothelial growth factor production;proteoglycan metabolic process;regulation of hair follicle development;vascular wound healing","beta-glucuronidase activity;heparanase activity;protein dimerization activity;syndecan binding","extracellular region;intracellular membrane-bounded organelle;lysosomal lumen;lysosomal membrane;lysosome;membrane raft;nucleoplasm;nucleus;proteinaceous extracellular matrix;specific granule lumen","Glycosaminoglycan degradation;Metabolic pathways;Proteoglycans in cancer",null,null,10,10,10,"25.2","25.2","25.2","61.148",0,"25.433",340660000,32,"0.462439",1,"1.63942","1.07024","sp|Q9Y251|HPSE_HUMAN","sp|Q9Y251|HPSE_HUMAN",5202,"Q9Y251","HPSE_HUMAN","Heparanase",null,"HPSE"]
["22.713","21.8285","21.3009","19.1163","20.9308","20.8794",{"$nulls":9},7,7,5,"13.1","13.1","9.9","84.109",0,"71.76",6334600000,114,"1.06232",1,"1.63861","2.2605","tr|G3V325|G3V325_HUMAN;sp|O75127|PTCD1_HUMAN;tr|C9JJT5|C9JJT5_HUMAN;tr|C9JGL8|C9JGL8_HUMAN;tr|C9JWL7|C9JWL7_HUMAN;tr|C9JQN9|C9JQN9_HUMAN","tr|G3V325|G3V325_HUMAN;sp|O75127|PTCD1_HUMAN",5548,"G3V325","G3V325_HUMAN",null,null,"ATP5MF-PTCD1"]
["20.3483","19.4532","20.0188","17.8398","17.986","19.1184",{"$nulls":9},4,4,4,"16.6","16.6","16.6","34.815",0,"6.6373",91629000,7,"1.55523",1,"1.62537","3.37762","tr|Q9UFM8|Q9UFM8_HUMAN;sp|Q9Y639|NPTN_HUMAN;tr|H3BU51|H3BU51_HUMAN;tr|H3BQ94|H3BQ94_HUMAN","tr|Q9UFM8|Q9UFM8_HUMAN;sp|Q9Y639|NPTN_HUMAN;tr|H3BU51|H3BU51_HUMAN",5387,"Q9UFM8","Q9UFM8_HUMAN",null,null,"DKFZp566H1924"]
["20.6369","19.9012","17.5392","16.6208","19.3227","17.2613",{"$nulls":3},"bicarbonate transport;platelet degranulation;positive regulation of protein targeting to mitochondrion;sterol biosynthetic process","cytochrome-b5 reductase activity, acting on NAD(P)H;oxidoreductase activity","endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;membrane;mitochondrion;plasma membrane;platelet alpha granule membrane","Amino sugar and nucleotide sugar metabolism",null,null,7,7,7,"29.2","29.2","29.2","34.094",0,"20.578",94825000,7,"0.58432",1,"1.62412","1.3098","sp|Q9UHQ9|NB5R1_HUMAN;tr|H7C0R7|H7C0R7_HUMAN","sp|Q9UHQ9|NB5R1_HUMAN;tr|H7C0R7|H7C0R7_HUMAN",5030,"Q9UHQ9","NB5R1_HUMAN","NADH-cytochrome b5 reductase 1","5R.1","CYB5R1"]
["20.9725","20.1672","20.3694","19.4266","18.0253","19.1897",{"$nulls":3},"hemidesmosome assembly","actin binding;ankyrin binding;cadherin binding;RNA binding;structural constituent of muscle","brush border;costamere;cytosol;extracellular exosome;extracellular matrix;focal adhesion;hemidesmosome;intermediate filament cytoskeleton;plasma membrane;sarcolemma;sarcoplasm",{"$nulls":3},133,133,131,"38.5","38.5","37.8","531.78",0,"323.31",3428400000,308,"1.51201",1,"1.62249","3.27101","sp|Q15149|PLEC_HUMAN;tr|E9PMV1|E9PMV1_HUMAN;tr|H0YDN1|H0YDN1_HUMAN;tr|E9PKG0|E9PKG0_HUMAN;tr|E9PQ28|E9PQ28_HUMAN;tr|E9PIA2|E9PIA2_HUMAN","sp|Q15149|PLEC_HUMAN",2565,"Q15149","PLEC_HUMAN","Plectin","CN;LTN","PLEC"]
["19.885","17.3511","20.339","16.4809","16.8387","19.4227",{"$nulls":3},"cellular response to oxidative stress","glutathione peroxidase activity;peroxidase activity","endoplasmic reticulum lumen;integral component of membrane","Arachidonic acid metabolism;Glutathione metabolism;Metabolic pathways;Thyroid hormone synthesis",null,null,5,5,5,"30.1","30.1","30.1","23.881",0,"14.756",147770000,24,"0.542115",1,"1.61095","1.2273","sp|Q8TED1|GPX8_HUMAN;tr|E7ETY7|E7ETY7_HUMAN;tr|J3KNB5|J3KNB5_HUMAN","sp|Q8TED1|GPX8_HUMAN;tr|E7ETY7|E7ETY7_HUMAN",3577,"Q8TED1","GPX8_HUMAN","Probable glutathione peroxidase 8","Px-8;SHPx-8","GPX8"]
["24.0309","22.4358","22.3278","20.6901","20.8891","22.3835",{"$nulls":3},"cellular respiration;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;negative regulation of cell growth;negative regulation of intrinsic apoptotic signaling pathway;reactive oxygen species metabolic process;substantia nigra development","electron transfer activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity","mitochondrial matrix;mitochondrial membrane;mitochondrial respiratory chain complex I;mitochondrion;myelin sheath;nuclear body","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,14,14,14,"49.2","49.2","49.2","30.241",0,"116.87",1119500000,64,"0.983978",1,"1.61061","2.0991","sp|O75489|NDUS3_HUMAN;tr|E9PS48|E9PS48_HUMAN;tr|G3V194|G3V194_HUMAN;tr|E9PKL8|E9PKL8_HUMAN","sp|O75489|NDUS3_HUMAN",597,"O75489","NDUS3_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial",null,"NDUFS3"]
["25.751","24.1143","24.1574","22.7666","22.6036","23.8435",{"$nulls":3},"ATP synthesis coupled electron transport;lactation;mitochondrial electron transport, cytochrome c to oxygen;response to cold","copper ion binding;cytochrome-c oxidase activity","extracellular exosome;integral component of membrane;membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex IV;mitochondrion;respiratory chain complex IV","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,7,7,7,"32.2","32.2","32.2","25.565",0,"73.611",1381600000,72,"1.13478",1,"1.60301","2.41296","sp|P00403|COX2_HUMAN","sp|P00403|COX2_HUMAN",825,"P00403","COX2_HUMAN","Cytochrome c oxidase subunit 2",null,"MT-CO2"]
["18.7599","17.9592",1,"15.4169","16.5126",1,{"$nulls":3},"amino acid transmembrane transport;bone development;sodium ion transport","amino acid transmembrane transporter activity","Golgi apparatus;integral component of membrane",{"$nulls":3},5,5,5,8,8,8,"119.76",0,"22.295",83521000,11,"0.0732071",1,"1.59656","0.208705","sp|Q9HBR0|S38AA_HUMAN","sp|Q9HBR0|S38AA_HUMAN",4579,"Q9HBR0","S38AA_HUMAN","Putative sodium-coupled neutral amino acid transporter 10",null,"SLC38A10"]
["20.0239","17.8632","18.1033","16.6141","16.9937","17.5946",{"$nulls":3},"Golgi organization;Golgi to plasma membrane protein transport;Golgi vesicle budding;positive regulation of protein secretion;retrograde vesicle-mediated transport, Golgi to ER","phosphatidylinositol-4-phosphate binding","cytosol;Golgi cisterna;Golgi cisterna membrane;Golgi membrane;trans-Golgi network;trans-Golgi network membrane",{"$nulls":3},3,3,3,"22.1","22.1","22.1","32.767",0,"8.3214",48965000,6,"1.01086",1,"1.59603","2.15412","sp|Q9H4A5|GLP3L_HUMAN;tr|Q5T5I6|Q5T5I6_HUMAN","sp|Q9H4A5|GLP3L_HUMAN;tr|Q5T5I6|Q5T5I6_HUMAN",4462,"Q9H4A5","GLP3L_HUMAN","Golgi phosphoprotein 3-like",null,"GOLPH3L"]
["21.0946","20.1333","20.6801","19.5883","17.3845","20.1552",{"$nulls":3},"membrane organization;positive regulation of neuron projection development;protein targeting to lysosome;regulation of endosome organization;regulation of glucosylceramidase activity;regulation of lysosome organization","enzyme binding;receptor activity;virus receptor activity","clathrin-coated vesicle membrane;extracellular exosome;focal adhesion;integral component of membrane;late endosome membrane;lysosomal lumen;lysosomal membrane;membrane;plasma membrane","Lysosome",null,null,6,6,6,"15.7","15.7","15.7","54.29",0,"24.347",243690000,21,"0.830277",1,"1.59336","1.79078","sp|Q14108|SCRB2_HUMAN;tr|D6RDG0|D6RDG0_HUMAN","sp|Q14108|SCRB2_HUMAN",2431,"Q14108","SCRB2_HUMAN","Lysosome membrane protein 2",null,"SCARB2"]
["20.4463","18.0077","20.0177","16.4773","16.9356","20.3087",{"$nulls":3},"cell adhesion;positive regulation of synapse assembly",null,"cell surface;endoplasmic reticulum;integral component of plasma membrane",{"$nulls":3},4,4,4,"13.3","13.3","13.3","46.031",0,"6.3203",102340000,4,"0.483925",1,"1.58333","1.11282","sp|Q13641|TPBG_HUMAN","sp|Q13641|TPBG_HUMAN",2400,"Q13641","TPBG_HUMAN","Trophoblast glycoprotein",null,"TPBG"]
["23.0491","22.5588","22.129","19.583","21.3276","22.0841",{"$nulls":3},"brain development;cAMP-mediated signaling;cellular respiration;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;positive regulation of fibroblast proliferation;reactive oxygen species metabolic process;regulation of protein phosphorylation;response to cAMP","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,5,5,5,"39.4","39.4","39.4","20.108",0,"26.241",431620000,27,"0.939565",1,"1.58071","2.009","sp|O43181|NDUS4_HUMAN;tr|H0Y9M8|H0Y9M8_HUMAN","sp|O43181|NDUS4_HUMAN",393,"O43181","NDUS4_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial",null,"NDUFS4"]
["19.5926","18.1793","18.74","19.2117","17.5985","14.9651",{"$nulls":3},"cellular response to DNA damage stimulus;defense response to virus;double-strand break repair;endosome to lysosome transport;histone H2A ubiquitination;histone H2B ubiquitination;histone monoubiquitination;innate immune response;negative regulation of ubiquitin-protein transferase activity;positive regulation of chromatin binding;positive regulation of defense response to virus by host;positive regulation of double-strand break repair via nonhomologous end joining;positive regulation of NAD+ ADP-ribosyltransferase activity;positive regulation of protein binding;positive regulation of protein localization to early endosome;positive regulation of protein localization to nucleus;positive regulation of receptor catabolic process;positive regulation of transcription, DNA-templated;protein autoubiquitination;protein K48-linked ubiquitination;protein polyubiquitination;protein transport;protein ubiquitination involved in ubiquitin-dependent protein catabolic process","enzyme activator activity;enzyme binding;enzyme inhibitor activity;histone binding;metal ion binding;RNA binding;STAT family protein binding;ubiquitin-like protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;cytosol;early endosome membrane;lysosomal membrane;lysosome;nucleoplasm;nucleus;protein complex","Notch signaling pathway",null,null,16,16,16,"27.7","27.7","27.7","83.553",0,"147.98",497500000,46,"0.533672",1,"1.57888","1.21075","sp|Q8TDB6|DTX3L_HUMAN","sp|Q8TDB6|DTX3L_HUMAN",3562,"Q8TDB6","DTX3L_HUMAN","E3 ubiquitin-protein ligase DTX3L",null,"DTX3L"]
["21.9326","19.8924","20.0089","18.3179","19.4563","19.3265",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;negative regulation of ERBB signaling pathway;negative regulation of multicellular organism growth;negative regulation of neuron apoptotic process;proteolysis;proteolysis involved in cellular protein catabolic process;receptor catabolic process;renal system process;response to acidic pH;toll-like receptor signaling pathway;vacuolar protein processing;vitamin D metabolic process","cysteine-type endopeptidase activity;peptidase activity","apical part of cell;endolysosome lumen;extracellular exosome;late endosome;lysosomal lumen;lysosome","Antigen processing and presentation;Lysosome",null,null,4,4,4,"9.9","9.9","9.9","49.411",0,"90.981",323600000,15,"0.982048",1,"1.57773","2.09517","sp|Q99538|LGMN_HUMAN;tr|G3V2T4|G3V2T4_HUMAN;tr|G3V4E4|G3V4E4_HUMAN;tr|H0YJN9|H0YJN9_HUMAN","sp|Q99538|LGMN_HUMAN;tr|G3V2T4|G3V2T4_HUMAN;tr|G3V4E4|G3V4E4_HUMAN",4073,"Q99538","LGMN_HUMAN","Legumain",null,"LGMN"]
["20.9074","20.3892","19.9884","19.699","18.2953","18.5612",{"$nulls":3},"cell differentiation;multicellular organism development;negative regulation of transcription, DNA-templated","transcription corepressor activity","cytosol;microtubule;nucleus",{"$nulls":3},14,14,14,"23.8","23.8","23.8","80.642",0,"54.689",445070000,49,"1.44755",1,"1.57652","3.11549","sp|Q96AQ6|PBIP1_HUMAN;tr|F2Z2Z8|F2Z2Z8_HUMAN;tr|Q5T173|Q5T173_HUMAN","sp|Q96AQ6|PBIP1_HUMAN",3793,"Q96AQ6","PBIP1_HUMAN","Pre-B-cell leukemia transcription factor-interacting protein 1",null,"PBXIP1"]
["20.6753","17.5805","16.6814","17.0107","16.4709","16.7431",{"$nulls":3},"mitochondrion organization","calcium ion binding;GTP binding;GTPase activity","integral component of mitochondrial outer membrane",{"$nulls":3},5,4,4,"9.9",8,8,"68.449",0,"7.1907",102420000,9,"0.573137",1,"1.57083","1.28797","tr|H7BXZ6|H7BXZ6_HUMAN;sp|Q8IXI2|MIRO1_HUMAN;tr|K7EIQ7|K7EIQ7_HUMAN","tr|H7BXZ6|H7BXZ6_HUMAN;sp|Q8IXI2|MIRO1_HUMAN",3320,"H7BXZ6","H7BXZ6_HUMAN","Mitochondrial Rho GTPase {ECO:0000256|PIRNR:PIRNR037488}"]
["24.9014","24.5203","24.1279","22.763","22.987","23.1018",{"$nulls":3},"angiogenesis;angiotensin-activated signaling pathway involved in heart process;apoptotic signaling pathway;beta-catenin destruction complex disassembly;calcium ion homeostasis;calcium ion transport;caveola assembly;caveolin-mediated endocytosis;cellular calcium ion homeostasis;cellular response to exogenous dsRNA;cellular response to hyperoxia;cellular response to peptide hormone stimulus;cellular response to starvation;cellular response to transforming growth factor beta stimulus;cholesterol homeostasis;cholesterol transport;inactivation of MAPK activity;lactation;leukocyte migration;lipid storage;maintenance of protein location in cell;mammary gland development;mammary gland involution;membrane depolarization;negative regulation of anoikis;negative regulation of BMP signaling pathway;negative regulation of canonical Wnt signaling pathway;negative regulation of cytokine-mediated signaling pathway;negative regulation of endothelial cell proliferation;negative regulation of epithelial cell differentiation;negative regulation of inward rectifier potassium channel activity;negative regulation of JAK-STAT cascade;negative regulation of MAPK cascade;negative regulation of necroptotic process;negative regulation of nitric oxide biosynthetic process;negative regulation of nitric-oxide synthase activity;negative regulation of peptidyl-serine phosphorylation;negative regulation of peptidyl-tyrosine autophosphorylation;negative regulation of pinocytosis;negative regulation of potassium ion transmembrane transport;negative regulation of protein binding;negative regulation of protein tyrosine kinase activity;negative regulation of protein ubiquitination;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transforming growth factor beta receptor signaling pathway;negative regulation of tyrosine phosphorylation of STAT protein;nitric oxide homeostasis;positive regulation of calcium ion transport into cytosol;positive regulation of canonical Wnt signaling pathway;positive regulation of catalytic activity;positive regulation of cell adhesion molecule production;positive regulation of ER-associated ubiquitin-dependent protein catabolic process;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of gap junction assembly;positive regulation of gene expression;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein binding;positive regulation of protein ubiquitination;positive regulation of toll-like receptor 3 signaling pathway;positive regulation of vasoconstriction;posttranscriptional regulation of gene expression;protein homooligomerization;protein localization;protein localization to basolateral plasma membrane;protein localization to plasma membrane raft;receptor internalization;receptor internalization involved in canonical Wnt signaling pathway;receptor-mediated endocytosis of virus by host cell;regulation of blood coagulation;regulation of cardiac muscle cell action potential involved in regulation of contraction;regulation of cell communication by electrical coupling involved in cardiac conduction;regulation of cytosolic calcium ion concentration;regulation of entry of bacterium into host cell;regulation of fatty acid metabolic process;regulation of heart rate by cardiac conduction;regulation of membrane repolarization during action potential;regulation of nitric-oxide synthase activity;regulation of peptidase activity;regulation of ruffle assembly;regulation of smooth muscle contraction;regulation of the force of heart contraction by chemical signal;regulation of ventricular cardiac muscle cell action potential;response to bacterium;response to calcium ion;response to estrogen;response to hypoxia;response to ischemia;response to progesterone;skeletal muscle tissue development;T cell costimulation;triglyceride metabolic process;vasculogenesis;vasoconstriction;vesicle organization","ATPase binding;cholesterol binding;enzyme binding;identical protein binding;inward rectifier potassium channel inhibitor activity;ion channel binding;nitric-oxide synthase binding;patched binding;peptidase activator activity;protein binding, bridging;protein complex scaffold activity;protein heterodimerization activity;protein kinase binding;Rac GTPase binding;receptor binding;structural molecule activity","acrosomal membrane;apical plasma membrane;basolateral plasma membrane;caveola;cell cortex;cilium;cytoplasmic vesicle;early endosome membrane;endocytic vesicle membrane;endoplasmic reticulum;endoplasmic reticulum membrane;endosome;focal adhesion;Golgi membrane;integral component of plasma membrane;intracellular;lipid droplet;membrane;membrane raft;perinuclear region of cytoplasm;plasma membrane;protein complex","Bacterial invasion of epithelial cells;Endocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;Proteoglycans in cancer;Viral myocarditis",null,null,4,4,2,"30.3","30.3","12.9","20.471",0,"51.606",1415400000,35,"2.5155",1,"1.56592","6.4054","sp|Q03135|CAV1_HUMAN;tr|E9PCT5|E9PCT5_HUMAN;sp|P56539|CAV3_HUMAN","sp|Q03135|CAV1_HUMAN;tr|E9PCT5|E9PCT5_HUMAN",2172,"Q03135","CAV1_HUMAN","Caveolin-1",null,"CAV1"]
["24.1608","21.5708","23.0289","23.0434","17.9436","23.1021",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity;protein complex binding","mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,7,7,7,"46.5","46.5","46.5","20.105",0,"60.558",604580000,39,"0.345673",1,"1.55713","0.834067","sp|P51970|NDUA8_HUMAN","sp|P51970|NDUA8_HUMAN",1762,"P51970","NDUA8_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8",null,"NDUFA8"]
["23.5328","21.5825","20.4255","21.1042","19.68","20.0946",{"$nulls":3},"cholesterol biosynthetic process;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding transcription factor activity;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;zinc ion binding","cytosol;endoplasmic reticulum;nucleus",{"$nulls":3},5,5,5,"34.5","34.5","34.5","19.463",0,"81.407",313930000,20,"0.709245",1,"1.55399","1.55325","sp|P62633|CNBP_HUMAN;tr|D6RAT4|D6RAT4_HUMAN","sp|P62633|CNBP_HUMAN",1984,"P62633","CNBP_HUMAN","Cellular nucleic acid-binding protein","NBP","CNBP"]
["19.9606","18.9266","19.0488","17.5427","17.6277","18.1538",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;RNA splicing;RNA splicing, via transesterification reactions;spliceosomal tri-snRNP complex assembly","identical protein binding;RNA binding","Cajal body;cytosol;nuclear speck;nucleoplasm;nucleus;protein complex;spliceosomal complex;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,15,15,15,"32.8","32.8","32.8","77.528",0,"45.827",549150000,62,"1.81613",1,"1.53726","4.06616","sp|O43395|PRPF3_HUMAN","sp|O43395|PRPF3_HUMAN",414,"O43395","PRPF3_HUMAN","U4/U6 small nuclear ribonucleoprotein Prp3",null,"PRPF3"]
["19.8196","20.3689",1,"19.8458","15.7449",1,{"$nulls":3},"basement membrane organization;cellular response to BMP stimulus;epithelial cell morphogenesis involved in placental branching;establishment or maintenance of cell polarity;movement of cell or subcellular component;negative regulation of cell motility;negative regulation of cell-cell adhesion;negative regulation of neural precursor cell proliferation;neural tube closure","endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity","cytoplasm;extracellular region;integral component of membrane;plasma membrane",{"$nulls":3},3,3,3,"15.1","15.1","15.1","28.228",0,"7.7906",143860000,11,"0.062175",1,"1.5326","0.179035","sp|O43291|SPIT2_HUMAN;tr|K7EM91|K7EM91_HUMAN;tr|K7EKC8|K7EKC8_HUMAN;tr|K7EKQ0|K7EKQ0_HUMAN","sp|O43291|SPIT2_HUMAN;tr|K7EM91|K7EM91_HUMAN",402,"O43291","SPIT2_HUMAN","Kunitz-type protease inhibitor 2",null,"SPINT2"]
["21.2716","20.0667","20.5082","19.4322","18.5204","19.3589",{"$nulls":9},17,14,14,"31.6","28.5","28.5","69.948",0,"43.45",501540000,46,"1.52526",1,"1.51169","3.30347","tr|J9JID7|J9JID7_HUMAN;sp|Q03252|LMNB2_HUMAN","tr|J9JID7|J9JID7_HUMAN;sp|Q03252|LMNB2_HUMAN",2175,"J9JID7"]
["20.1577","19.6639","20.0922","18.6677","18.6575","18.0562",{"$nulls":3},"cell-cell signaling;cellular protein metabolic process;constitutive protein ectodomain proteolysis;extracellular matrix disassembly;in utero embryonic development;integrin-mediated signaling pathway;membrane protein ectodomain proteolysis;monocyte activation;negative regulation of cell adhesion;neutrophil degranulation;Notch receptor processing;Notch signaling pathway;PMA-inducible membrane protein ectodomain proteolysis;positive regulation of cell growth;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of T cell chemotaxis;post-translational protein modification;protein phosphorylation;protein processing;response to tumor necrosis factor","endopeptidase activity;integrin binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;protein homodimerization activity;protein kinase binding;receptor binding;SH3 domain binding","cell surface;cytoplasm;endoplasmic reticulum lumen;extracellular exosome;focal adhesion;Golgi apparatus;Golgi membrane;Golgi-associated vesicle;integral component of membrane;membrane;nucleus;perinuclear endoplasmic reticulum;plasma membrane;postsynaptic density;specific granule membrane;tertiary granule membrane;tetraspanin-enriched microdomain","Alzheimer disease;Epithelial cell signaling in Helicobacter pylori infection",null,null,12,12,12,"22.9","22.9","22.9","84.141",0,"38.81",300270000,30,"2.39306",1,"1.51082","5.93312","sp|O14672|ADA10_HUMAN;tr|H3BS53|H3BS53_HUMAN;tr|H0YNC5|H0YNC5_HUMAN","sp|O14672|ADA10_HUMAN",284,"O14672","ADA10_HUMAN","Disintegrin and metalloproteinase domain-containing protein 10","DAM 10","ADAM10"]
["18.1495","14.0975","11.8563","13.8154","12.6182","13.1445",{"$nulls":3},"centrosome localization;cytoskeletal anchoring at nuclear membrane;establishment or maintenance of cell polarity;fibroblast migration;nuclear envelope organization;nuclear migration;nuclear migration along microfilament;nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;positive regulation of cell migration;protein localization to nucleus;regulation of cilium assembly","actin binding;actin filament binding","aggresome;cytoplasm;extracellular exosome;filopodium membrane;focal adhesion;integral component of membrane;intermediate filament cytoskeleton;lamellipodium membrane;LINC complex;mitochondrion;nuclear envelope;nuclear lumen;nuclear membrane;nuclear outer membrane;nucleoplasm;nucleus;sarcoplasmic reticulum;sarcoplasmic reticulum membrane;Z disc",{"$nulls":3},22,22,22,"4.5","4.5","4.5","796.43",0,"33.835",239650000,24,"0.331645",1,"1.50842","0.804958","sp|Q8WXH0|SYNE2_HUMAN;tr|G3V5X4|G3V5X4_HUMAN;tr|A0A0A0MRE3|A0A0A0MRE3_HUMAN;tr|A0A0C4DGK3|A0A0C4DGK3_HUMAN;tr|A0A0C4DH87|A0A0C4DH87_HUMAN;tr|G3V5D3|G3V5D3_HUMAN;tr|G3V5N1|G3V5N1_HUMAN;tr|G3V3D4|G3V3D4_HUMAN;tr|G3V4T3|G3V4T3_HUMAN","sp|Q8WXH0|SYNE2_HUMAN;tr|G3V5X4|G3V5X4_HUMAN;tr|A0A0A0MRE3|A0A0A0MRE3_HUMAN;tr|A0A0C4DGK3|A0A0C4DGK3_HUMAN",3647,"Q8WXH0","SYNE2_HUMAN","Nesprin-2",null,"SYNE2"]
["21.2129","19.6395","20.795","19.5138","18.1365","19.4841",{"$nulls":3},"androgen receptor signaling pathway;circadian rhythm;intracellular steroid hormone receptor signaling pathway;mRNA processing;mRNA stabilization;nuclear-transcribed mRNA catabolic process;positive regulation of circadian rhythm;positive regulation of mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of alternative mRNA splicing, via spliceosome;RNA splicing;transcription initiation from RNA polymerase II promoter","ATP binding;core promoter sequence-specific DNA binding;ligand-dependent nuclear receptor transcription coactivator activity;phosphoprotein binding;receptor activity;RNA binding;RNA polymerase II transcription cofactor activity;thyroid hormone receptor binding;transcription coactivator activity;transcription cofactor activity;vitamin D receptor binding","extracellular exosome;mediator complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},18,18,17,"21.8","21.8","21.8","108.66",0,"114.59",740640000,70,"1.08127",1,"1.50434","2.30006","sp|Q9Y2W1|TR150_HUMAN","sp|Q9Y2W1|TR150_HUMAN",5247,"Q9Y2W1","TR150_HUMAN","Thyroid hormone receptor-associated protein 3",null,"THRAP3"]
["22.7216","21.7816","22.2094","20.8074","20.0668","21.3504",{"$nulls":4},"RNA binding;zinc ion binding",{"$nulls":4},7,7,6,"42.3","42.3","42.3","15.763",0,"21.202",380610000,25,"1.50242",1,"1.49602","3.24759","tr|A0A0B4J1Z1|A0A0B4J1Z1_HUMAN;tr|C9JAB2|C9JAB2_HUMAN;sp|Q16629|SRSF7_HUMAN","tr|A0A0B4J1Z1|A0A0B4J1Z1_HUMAN;tr|C9JAB2|C9JAB2_HUMAN;sp|Q16629|SRSF7_HUMAN",2679,"A0A0B4J1Z1","A0A0B4J1Z1_HUMAN",null,null,"SRSF7"]
["19.3568","18.3645","18.7871","17.2962","17.4266","17.2997",{"$nulls":4},"oxidoreductase activity",{"$nulls":4},10,10,10,"16.2","16.2","16.2","88.569",0,"23.238",174430000,14,"2.16922",1,"1.49532","5.14388","tr|A8MT40|A8MT40_HUMAN;sp|Q8NCN5|PDPR_HUMAN;tr|B7ZAR9|B7ZAR9_HUMAN;tr|H3BQG3|H3BQG3_HUMAN;tr|H3BUH3|H3BUH3_HUMAN","tr|A8MT40|A8MT40_HUMAN;sp|Q8NCN5|PDPR_HUMAN",3474,"A8MT40","A8MT40_HUMAN",null,null,"PDPR"]
["20.0331","18.1536","17.8238","17.3132","16.2765","17.9489",{"$nulls":3},"cell differentiation;DNA dealkylation involved in DNA repair;mRNA export from nucleus;mRNA processing;oxidative single-stranded RNA demethylation;response to hypoxia;spermatogenesis","metal ion binding;oxidative RNA demethylase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;RNA binding","cytosol;Golgi apparatus;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"16.5","16.5","16.5","44.255",0,"13.395",65876000,4,"0.818641",1,"1.49061","1.76779","sp|Q6P6C2|ALKB5_HUMAN;tr|K7ER58|K7ER58_HUMAN","sp|Q6P6C2|ALKB5_HUMAN",3020,"Q6P6C2","ALKB5_HUMAN","RNA demethylase ALKBH5 {ECO:0000303|PubMed:24616105}",null,"ALKBH5"]
["19.3478","18.3181","19.1802","15.194","17.5772","19.6198",{"$nulls":3},"carbohydrate metabolic process;chondroitin sulfate metabolic process;chondroitin sulfate proteoglycan biosynthetic process;dermatan sulfate proteoglycan biosynthetic process;glycosaminoglycan biosynthetic process;glycosaminoglycan metabolic process;heparan sulfate proteoglycan biosynthetic process;positive regulation of catalytic activity;positive regulation of intracellular protein transport;protein glycosylation","galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;glucuronosyltransferase activity;metal ion binding;protein phosphatase activator activity","cis-Golgi network;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of membrane;membrane","Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate;Glycosaminoglycan biosynthesis - heparan sulfate / heparin;Metabolic pathways",null,null,12,12,12,"37.3","37.3","37.3","37.121",0,"85.541",716100000,67,"0.49094",1,"1.48505","1.12668","sp|O94766|B3GA3_HUMAN;tr|G3V150|G3V150_HUMAN;tr|E9PNA1|E9PNA1_HUMAN;tr|A0A087WXU9|A0A087WXU9_HUMAN;sp|Q9NPZ5|B3GA2_HUMAN","sp|O94766|B3GA3_HUMAN;tr|G3V150|G3V150_HUMAN",674,"O94766","B3GA3_HUMAN","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3",null,"B3GAT3"]
["21.3118","20.981","20.8362","19.7212","19.2069","19.7974",{"$nulls":3},"cellular response to interleukin-1;membrane protein ectodomain proteolysis;mRNA splice site selection;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;osteoblast differentiation;positive regulation of mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;protein homooligomerization;protein oligomerization;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;transcription from RNA polymerase II promoter","chromatin binding;core promoter binding;identical protein binding;mRNA binding;protein domain specific binding;RNA binding;single-stranded RNA binding","catalytic step 2 spliceosome;extracellular exosome;extracellular space;intracellular ribonucleoprotein complex;membrane;nuclear euchromatin;nucleoplasm;nucleus;supraspliceosomal complex","Spliceosome",null,null,6,6,6,"17.1","17.1","17.1","42.331",0,"48.361",330240000,18,"2.49016",1,"1.46785","6.30514","sp|P38159|RBMX_HUMAN;tr|H0Y6E7|H0Y6E7_HUMAN;tr|H3BT71|H3BT71_HUMAN;tr|H3BR27|H3BR27_HUMAN;sp|Q96E39|RMXL1_HUMAN;tr|H3BNC1|H3BNC1_HUMAN;tr|H3BUY5|H3BUY5_HUMAN;sp|O75526|RMXL2_HUMAN;sp|Q8N7X1|RMXL3_HUMAN","sp|P38159|RBMX_HUMAN;tr|H0Y6E7|H0Y6E7_HUMAN;tr|H3BT71|H3BT71_HUMAN;tr|H3BR27|H3BR27_HUMAN;sp|Q96E39|RMXL1_HUMAN",1500,"P38159","RBMX_HUMAN","RNA-binding motif protein, X chromosome",null,"RBMX"]
["20.7326","19.4912","20.2938","18.6824","17.6661","19.7735",{"$nulls":3},"aspartate transport;ATP biosynthetic process;cellular respiration;gluconeogenesis;L-glutamate transport;malate-aspartate shuttle;mitochondrial transport;response to calcium ion","acidic amino acid transmembrane transporter activity;calcium ion binding;L-aspartate transmembrane transporter activity;L-glutamate transmembrane transporter activity;transporter activity","integral component of membrane;integral component of plasma membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},17,12,12,"35.7",28,28,"74.175",0,"76.692",367500000,37,"0.968308",1,"1.46517","2.0672","sp|Q9UJS0|CMC2_HUMAN;tr|R4GN64|R4GN64_HUMAN","sp|Q9UJS0|CMC2_HUMAN",5062,"Q9UJS0","CMC2_HUMAN","Calcium-binding mitochondrial carrier protein Aralar2",null,"SLC25A13"]
["17.3857","17.4529","18.3423","15.6633","14.2357","18.9002",{"$nulls":4},"RNA binding",{"$nulls":4},7,7,7,"30.6","30.6","30.6","34.861",0,"15.79",67250000,11,"0.443743",1,"1.46056","1.03301","tr|E5RJN7|E5RJN7_HUMAN;tr|A0A0A0MTC4|A0A0A0MTC4_HUMAN;tr|A0A0A0MTD1|A0A0A0MTD1_HUMAN;tr|F8VPI7|F8VPI7_HUMAN;tr|E7EPX0|E7EPX0_HUMAN;tr|A0A0A0MTC6|A0A0A0MTC6_HUMAN;tr|E7EVJ4|E7EVJ4_HUMAN;tr|E9PH62|E9PH62_HUMAN;tr|A0A0A0MTC5|A0A0A0MTC5_HUMAN;sp|Q9NUL3|STAU2_HUMAN;tr|G5EA18|G5EA18_HUMAN;tr|E7EVI1|E7EVI1_HUMAN;tr|E5RJ67|E5RJ67_HUMAN;tr|H0YBY0|H0YBY0_HUMAN;tr|E5RFK1|E5RFK1_HUMAN","tr|E5RJN7|E5RJN7_HUMAN;tr|A0A0A0MTC4|A0A0A0MTC4_HUMAN;tr|A0A0A0MTD1|A0A0A0MTD1_HUMAN;tr|F8VPI7|F8VPI7_HUMAN;tr|E7EPX0|E7EPX0_HUMAN;tr|A0A0A0MTC6|A0A0A0MTC6_HUMAN;tr|E7EVJ4|E7EVJ4_HUMAN;tr|E9PH62|E9PH62_HUMAN;tr|A0A0A0MTC5|A0A0A0MTC5_HUMAN;sp|Q9NUL3|STAU2_HUMAN;tr|G5EA18|G5EA18_HUMAN;tr|E7EVI1|E7EVI1_HUMAN;tr|E5RJ67|E5RJ67_HUMAN",4731,"E5RJN7","E5RJN7_HUMAN",null,null,"STAU2"]
["20.9285","20.1169",1,"19.1734","17.494",1,{"$nulls":3},"mitochondrial ATP synthesis coupled proton transport;mitochondrial electron transport, cytochrome c to oxygen;respiratory gaseous exchange","cytochrome-c oxidase activity;metal ion binding","extracellular exosome;mitochondrial inner membrane;mitochondrial respiratory chain complex IV;mitochondrion","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,4,4,4,"28.7","28.7","28.7","13.696","0.00021617","5.1129",49470000,4,"0.0578949",1,"1.45936","0.167376","sp|P10606|COX5B_HUMAN","sp|P10606|COX5B_HUMAN",1022,"P10606","COX5B_HUMAN","Cytochrome c oxidase subunit 5B, mitochondrial",null,"COX5B"]
["20.8164","20.1462","21.3831","19.1519","19.129","19.6983",{"$nulls":5},"fibrillar center;intracellular membrane-bounded organelle",{"$nulls":3},3,3,3,"19.1","19.1","19.1","32.57",0,"15.103",123550000,10,"1.64732",1,"1.45551","3.61153","tr|A0A0A0MT32|A0A0A0MT32_HUMAN;sp|P38571|LICH_HUMAN;tr|Q5T073|Q5T073_HUMAN;tr|Q5T770|Q5T770_HUMAN","tr|A0A0A0MT32|A0A0A0MT32_HUMAN;sp|P38571|LICH_HUMAN;tr|Q5T073|Q5T073_HUMAN",1502,"A0A0A0MT32","A0A0A0MT32_HUMAN",null,null,"LIPA"]
["18.7679","17.7429","17.7398","16.3552","17.5696","15.9778",{"$nulls":3},"autophagy;cell death;cellular response to unfolded protein;defense response to Gram-negative bacterium;G2/M transition of mitotic cell cycle;Golgi organization;Golgi ribbon formation;Golgi to plasma membrane protein transport;innate immune response;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of receptor recycling;parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization;positive regulation of autophagy;positive regulation of xenophagy;protein targeting to Golgi;regulation of I-kappaB kinase/NF-kappaB signaling;signal transduction","identical protein binding;K63-linked polyubiquitin modification-dependent protein binding;metal ion binding;polyubiquitin modification-dependent protein binding;protein binding, bridging;protein C-terminus binding;Rab GTPase binding","autophagosome;cytoplasm;cytoplasmic vesicle;cytosol;Golgi apparatus;Golgi membrane;nucleoplasm;nucleus;perinuclear region of cytoplasm;recycling endosome membrane;trans-Golgi network","Mitophagy - animal",null,null,4,4,4,"9.5","9.5","9.5","65.92",0,"24.532",82090000,10,"1.1559",1,"1.44937","2.45803","sp|Q96CV9|OPTN_HUMAN;tr|A0A087WY28|A0A087WY28_HUMAN;tr|H7C1H4|H7C1H4_HUMAN","sp|Q96CV9|OPTN_HUMAN",3831,"Q96CV9","OPTN_HUMAN","Optineurin",null,"OPTN"]
["18.8893","19.0356","18.4061","16.5581","18.7351","16.6911",{"$nulls":4},"RNA binding","integral component of membrane;nuclear membrane;nucleolus",{"$nulls":3},24,24,24,"23.8","23.8","23.8","143.7",0,"146.95",1483600000,114,"0.927904",1,"1.44894","1.98549","sp|Q5JTH9|RRP12_HUMAN;tr|A0A087X1U8|A0A087X1U8_HUMAN;tr|A0A087X0G0|A0A087X0G0_HUMAN;tr|H7C1M8|H7C1M8_HUMAN","sp|Q5JTH9|RRP12_HUMAN",2827,"Q5JTH9","RRP12_HUMAN","RRP12-like protein",null,"RRP12"]
["20.4835","18.3865","19.9875","17.0687","18.1824","19.2689",{"$nulls":3},"cell cycle;cell division;cell proliferation;signal transduction","identical protein binding;microtubule binding","cytoplasm;microtubule cytoskeleton;microtubule plus-end",{"$nulls":3},5,4,4,"23.2","20.8","20.8","37.031",0,"12.476",119580000,13,"0.739657",1,"1.44582","1.61266","sp|Q15555|MARE2_HUMAN;tr|M0QX52|M0QX52_HUMAN;tr|K7EL66|K7EL66_HUMAN;tr|K7ERD8|K7ERD8_HUMAN","sp|Q15555|MARE2_HUMAN",2614,"Q15555","MARE2_HUMAN","Microtubule-associated protein RP/EB family member 2",null,"MAPRE2"]
["19.0997","16.6485","18.6979","16.7293","16.0441","17.3381",{"$nulls":3},"7-methylguanosine mRNA capping;aging;apoptotic process;bone mineralization;cell proliferation;central nervous system myelin formation;chromosome segregation;embryonic cleavage;embryonic organ development;erythrocyte maturation;extracellular matrix organization;global genome nucleotide-excision repair;hair cell differentiation;hair follicle maturation;hematopoietic stem cell differentiation;in utero embryonic development;multicellular organism growth;nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;positive regulation of DNA binding;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;post-embryonic development;protein phosphorylation;regulation of mitotic cell cycle phase transition;response to hypoxia;response to oxidative stress;spinal cord development;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair;UV protection;viral process","4 iron, 4 sulfur cluster binding;5'-3' DNA helicase activity;ATP binding;ATP-dependent DNA helicase activity;DNA binding;DNA-dependent ATPase activity;metal ion binding;protein C-terminus binding;protein N-terminus binding","core TFIIH complex;cytoplasm;cytosol;holo TFIIH complex;MMXD complex;nucleoplasm;nucleus;spindle;transcription factor TFIID complex","Basal transcription factors;Nucleotide excision repair",null,null,8,8,8,"17.4","17.4","17.4","86.908",0,"59.024",168970000,27,"0.78816",1,"1.44486","1.70775","sp|P18074|ERCC2_HUMAN;tr|E7EVE9|E7EVE9_HUMAN;tr|A8MX75|A8MX75_HUMAN;tr|K7EKF3|K7EKF3_HUMAN;tr|K7EIT8|K7EIT8_HUMAN;tr|K7ENL1|K7ENL1_HUMAN;tr|B4E0F6|B4E0F6_HUMAN","sp|P18074|ERCC2_HUMAN;tr|E7EVE9|E7EVE9_HUMAN;tr|A8MX75|A8MX75_HUMAN",1171,"P18074","ERCC2_HUMAN","General transcription and DNA repair factor IIH helicase subunit XPD","FIIH subunit XPD","ERCC2"]
["24.8868","21.9371","23.2468","22.2062","20.7265","22.8148",{"$nulls":3},"leukocyte migration;negative regulation of cell-cell adhesion mediated by cadherin;positive regulation of cell proliferation;positive regulation of stem cell proliferation;positive regulation of transcription from RNA polymerase II promoter;signal transduction involved in regulation of gene expression;stem cell differentiation;ureteric bud development","cadherin binding involved in cell-cell adhesion;protein complex binding","apical plasma membrane;basolateral plasma membrane;bicellular tight junction;cell surface;extracellular exosome;integral component of plasma membrane;lateral plasma membrane;plasma membrane",{"$nulls":3},8,8,8,36,36,36,"34.932",0,"149.07",1533900000,76,"0.613266",1,"1.44109","1.36624","sp|P16422|EPCAM_HUMAN;tr|B5MCA4|B5MCA4_HUMAN;tr|C9JKY3|C9JKY3_HUMAN","sp|P16422|EPCAM_HUMAN;tr|B5MCA4|B5MCA4_HUMAN;tr|C9JKY3|C9JKY3_HUMAN",1136,"P16422","EPCAM_HUMAN","Epithelial cell adhesion molecule","p-CAM","EPCAM"]
["23.433","18.7111","19.6108","20.9853","17.212","19.2453",{"$nulls":3},"mRNA transport;negative regulation of vascular endothelial growth factor production;positive regulation of protein import into nucleus;protein export from nucleus;protein import into nucleus;protein import into nucleus, translocation;protein localization to nuclear pore","identical protein binding;nucleocytoplasmic transporter activity;protein transporter activity;Ran GTPase binding","cytosol;extracellular exosome;nuclear inner membrane;nuclear membrane;nuclear outer membrane;nuclear pore central transport channel;nucleoplasm",{"$nulls":3},5,5,5,"56.7","56.7","56.7","14.478",0,"19.447",122050000,11,"0.325995",1,"1.43742","0.793177","sp|P61970|NTF2_HUMAN;tr|H3BRV9|H3BRV9_HUMAN","sp|P61970|NTF2_HUMAN;tr|H3BRV9|H3BRV9_HUMAN",1948,"P61970","NTF2_HUMAN","Nuclear transport factor 2 {ECO:0000303|PubMed:7744965}","TF-2","NUTF2"]
["19.1696","19.0962","19.1103","16.0228","18.1533","18.8953",{"$nulls":3},"cell adhesion;cell-matrix adhesion;signal transduction","laminin binding;laminin receptor activity;protein C-terminus binding;transmembrane signaling receptor activity","external side of plasma membrane;extracellular exosome;extracellular matrix;extracellular region;integral component of plasma membrane;plasma membrane",{"$nulls":3},9,9,9,"22.6","22.6","22.6","67.404",0,"26.428",176070000,18,"0.766974",1,"1.43487","1.66615","sp|P50895|BCAM_HUMAN;tr|A0A087WXM8|A0A087WXM8_HUMAN;tr|K7ENU8|K7ENU8_HUMAN","sp|P50895|BCAM_HUMAN;tr|A0A087WXM8|A0A087WXM8_HUMAN",1720,"P50895","BCAM_HUMAN","Basal cell adhesion molecule",null,"BCAM"]
["19.109","15.0705","18.3692","17.4227","14.3931","16.453",{"$nulls":3},"carbohydrate metabolic process;glycosaminoglycan catabolic process;hyaluronan catabolic process;neutrophil degranulation","beta-glucuronidase activity;hydrolase activity, hydrolyzing O-glycosyl compounds;protein domain specific binding;receptor binding","azurophil granule lumen;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;intracellular membrane-bounded organelle;lysosomal lumen;lysosome;membrane","Drug metabolism - other enzymes;Glycosaminoglycan degradation;Lysosome;Metabolic pathways;Pentose and glucuronate interconversions;Porphyrin and chlorophyll metabolism",null,null,6,6,6,"13.5","13.5","13.5","74.731",0,"13.561",43796000,9,"0.393946",1,"1.42668","0.932873","sp|P08236|BGLR_HUMAN;tr|F8WBK6|F8WBK6_HUMAN;tr|F2Z3L6|F2Z3L6_HUMAN","sp|P08236|BGLR_HUMAN",958,"P08236","BGLR_HUMAN","Beta-glucuronidase",null,"GUSB"]
["21.0265","19.1389","19.9574","19.2538","18.4918","18.107",{"$nulls":3},"branched-chain amino acid catabolic process;brown fat cell differentiation;thymine catabolic process;thymine metabolic process;valine catabolic process;valine metabolic process","fatty-acyl-CoA binding;malonate-semialdehyde dehydrogenase (acetylating) activity;methylmalonate-semialdehyde dehydrogenase (acylating) activity;RNA binding","extracellular exosome;mitochondrial matrix;mitochondrion;nucleoplasm","beta-Alanine metabolism;Carbon metabolism;Inositol phosphate metabolism;Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,12,12,12,"28.6","28.6","28.6","57.839",0,"39.8",225670000,30,"1.0414",1,"1.42345","2.21707","sp|Q02252|MMSA_HUMAN;tr|G3V4Z4|G3V4Z4_HUMAN","sp|Q02252|MMSA_HUMAN;tr|G3V4Z4|G3V4Z4_HUMAN",2156,"Q02252","MMSA_HUMAN","Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial","alonate-semialdehyde dehydrogenase [acylating];MSDH","ALDH6A1"]
["27.4147","28.0561","27.7597","26.0826","26.5846","26.296",{"$nulls":4},"DNA binding;protein heterodimerization activity","nucleosome;nucleus",{"$nulls":3},5,5,1,47,47,"24.2","14.914",0,"179.58",15071000000,138,"2.42066",1,"1.42242","6.03694","tr|K7EK07|K7EK07_HUMAN;sp|P84243|H33_HUMAN","tr|K7EK07|K7EK07_HUMAN;sp|P84243|H33_HUMAN",2101,"K7EK07","K7EK07_HUMAN","Histone H3 {ECO:0000256|RuleBase:RU004471}",null,"H3F3B"]
["18.8475","16.9184","18.396","17.525","15.7578","16.6121",{"$nulls":3},"carbohydrate metabolic process;O-glycan processing;protein O-linked glycosylation","carbohydrate binding;metal ion binding;polypeptide N-acetylgalactosaminyltransferase activity","extracellular exosome;Golgi membrane;integral component of membrane;membrane","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,6,6,6,"11.9","11.9","11.9","75.388",0,"13.237",68111000,8,"0.853395",1,"1.4223","1.83658","sp|Q86SF2|GALT7_HUMAN;tr|H0YAK0|H0YAK0_HUMAN;tr|H0YAH3|H0YAH3_HUMAN;tr|E9PBY3|E9PBY3_HUMAN","sp|Q86SF2|GALT7_HUMAN;tr|H0YAK0|H0YAK0_HUMAN;tr|H0YAH3|H0YAH3_HUMAN",3202,"Q86SF2","GALT7_HUMAN","N-acetylgalactosaminyltransferase 7",null,"GALNT7"]
["18.2866","16.8037","16.7324","17.2547","16.6847","13.6425",{"$nulls":3},"axon extension;cellular process;dendrite development;establishment of monopolar cell polarity;microtubule bundle formation;mitochondrion transport along microtubule;negative regulation of intracellular transport;positive regulation of axon extension","microtubule binding;structural molecule activity","cell junction;cytosol;dendritic spine;microtubule;microtubule associated complex;photoreceptor outer segment;plasma membrane;postsynaptic density",{"$nulls":3},21,21,20,13,13,"12.6","270.63",0,"66.512",331050000,78,"0.502231",1,"1.4136","1.14895","sp|P46821|MAP1B_HUMAN;tr|D6RA40|D6RA40_HUMAN;tr|D6RA32|D6RA32_HUMAN","sp|P46821|MAP1B_HUMAN",1603,"P46821","MAP1B_HUMAN","Microtubule-associated protein 1B","AP-1B","MAP1B"]
["20.7548","17.9144","20.6035","19.7043","15.6773","19.6895",{"$nulls":3},"mRNA splicing, via spliceosome;RNA processing;RNA splicing;RNA splicing, via transesterification reactions","U4 snRNA binding;U6 snRNA binding","Cajal body;nuclear speck;nucleoplasm;nucleus;spliceosomal complex;spliceosomal snRNP complex;U4/U6 snRNP;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,11,11,11,"29.3","29.3","29.3","58.449",0,"42.315",658220000,65,"0.358707",1,"1.40056","0.860942","sp|O43172|PRP4_HUMAN","sp|O43172|PRP4_HUMAN",391,"O43172","PRP4_HUMAN","U4/U6 small nuclear ribonucleoprotein Prp4",null,"PRPF4"]
["23.3335","22.8143","23.4875","22.0461","21.4605","21.9365",{"$nulls":3},"base-excision repair;cell division;chondrocyte differentiation;chondrocyte proliferation;chromatin organization;chromosome breakage;chromosome condensation;DNA damage response, detection of DNA damage;endodermal cell differentiation;epithelial to mesenchymal transition;fat cell differentiation;heterochromatin assembly;histone H2A-S139 phosphorylation;mesenchymal cell differentiation;mesodermal cell differentiation;mesodermal-endodermal cell signaling;mitotic G2 DNA damage checkpoint;multicellular organism development;negative regulation by host of viral transcription;negative regulation of apoptotic process;negative regulation of cellular senescence;negative regulation of DNA binding;negative regulation of double-strand break repair via nonhomologous end joining;negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;oncogene-induced cell senescence;positive regulation of angiogenesis;positive regulation of apoptotic process;positive regulation of cell cycle arrest;positive regulation of cell proliferation in bone marrow;positive regulation of cellular response to X-ray;positive regulation of cellular senescence;positive regulation of gene expression;positive regulation of response to DNA damage stimulus;positive regulation of stem cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription regulatory region DNA binding;positive regulation of transcription, DNA-templated;regulation of cell cycle process;regulation of cellular response to drug;regulation of growth;regulation of stem cell population maintenance;regulation of transcription, DNA-templated;response to virus;senescence-associated heterochromatin focus assembly;stem cell differentiation","5'-deoxyribose-5-phosphate lyase activity;AT DNA binding;C2H2 zinc finger domain binding;cAMP response element binding;core promoter binding;DNA binding;DNA binding, bending;DNA-(apurinic or apyrimidinic site) lyase activity;DNA-dependent protein kinase activity;MH1 domain binding;MH2 domain binding;nucleosomal DNA binding;SMAD binding;transcription factor binding;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nuclear chromosome;nucleoplasm;nucleus;protein-DNA complex;senescence-associated heterochromatin focus;SMAD protein complex","MicroRNAs in cancer;Transcriptional misregulation in cancer",null,null,4,4,4,"56.9","56.9","56.9","11.832",0,"110.53",1106800000,66,"2.1695",1,"1.3974","5.14484","sp|P52926|HMGA2_HUMAN;tr|F5H2U8|F5H2U8_HUMAN;tr|F5H2A4|F5H2A4_HUMAN;tr|F5H6H0|F5H6H0_HUMAN","sp|P52926|HMGA2_HUMAN;tr|F5H2U8|F5H2U8_HUMAN;tr|F5H2A4|F5H2A4_HUMAN;tr|F5H6H0|F5H6H0_HUMAN",1786,"P52926","HMGA2_HUMAN","High mobility group protein HMGI-C",null,"HMGA2"]
["23.9721","22.3057","22.788","22.9359","19.7246","22.2374",{"$nulls":3},"adenylate cyclase-activating dopamine receptor signaling pathway;cardiac muscle cell apoptotic process;cell proliferation;cellular response to catecholamine stimulus;cellular response to glucagon stimulus;cellular response to hypoxia;cellular response to prostaglandin E stimulus;G-protein coupled acetylcholine receptor signaling pathway;G-protein coupled receptor signaling pathway;phospholipase C-activating G-protein coupled receptor signaling pathway;platelet activation;positive regulation of cytosolic calcium ion concentration;protein folding;protein heterotrimerization;Ras protein signal transduction;retina development in camera-type eye;rhodopsin mediated signaling pathway;sensory perception of taste;signal transduction;Wnt signaling pathway, calcium modulating pathway","alkylglycerophosphoethanolamine phosphodiesterase activity;GTPase activity;GTPase binding;protein complex binding;signal transducer activity;spectrin binding;type 1 angiotensin receptor binding","cell body;cytosol;dendrite;extracellular exosome;extracellular vesicle;heterotrimeric G-protein complex;intracellular;lysosomal membrane;membrane;myelin sheath;photoreceptor disc membrane;photoreceptor inner segment;photoreceptor outer segment membrane;plasma membrane","Alcoholism;Apelin signaling pathway;Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Dopaminergic synapse;GABAergic synapse;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Morphine addiction;Olfactory transduction;Pathways in cancer;Phototransduction;PI3K-Akt signaling pathway;Ras signaling pathway;Relaxin signaling pathway;Retrograde endocannabinoid signaling;Serotonergic synapse",null,null,12,7,7,"53.2",35,35,"37.377",0,"162.52",991940000,37,"0.564163",1,"1.38933","1.27044","sp|P62873|GBB1_HUMAN;tr|B1AKQ8|B1AKQ8_HUMAN;tr|F6UT28|F6UT28_HUMAN;tr|F6X3N5|F6X3N5_HUMAN;tr|B3KVK2|B3KVK2_HUMAN;tr|F5H8J8|F5H8J8_HUMAN;tr|F5H100|F5H100_HUMAN;tr|F5H0S8|F5H0S8_HUMAN;tr|E9PCP0|E9PCP0_HUMAN;sp|P16520|GBB3_HUMAN","sp|P62873|GBB1_HUMAN;tr|B1AKQ8|B1AKQ8_HUMAN;tr|F6UT28|F6UT28_HUMAN;tr|F6X3N5|F6X3N5_HUMAN",2002,"P62873","GBB1_HUMAN","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1",null,"GNB1"]
["20.6196","18.5239","18.9502","18.3092","17.4179","18.2026",{"$nulls":3},"aging;COPII vesicle coating;ER to Golgi vesicle-mediated transport;immune response;neutrophil degranulation;positive regulation of apoptotic signaling pathway;positive regulation of proteolysis involved in cellular protein catabolic process;proteolysis;proteolysis involved in cellular protein catabolic process;response to organic substance;T cell mediated cytotoxicity","chaperone binding;chloride ion binding;cysteine-type endopeptidase activity;cysteine-type peptidase activity;identical protein binding;peptidase activator activity involved in apoptotic process;phosphatase binding;protein self-association;serine-type endopeptidase activity","azurophil granule lumen;centrosome;COPII-coated ER to Golgi transport vesicle;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;extracellular region;extracellular space;Golgi membrane;intracellular membrane-bounded organelle;lysosome;membrane;nucleoplasm","Apoptosis;Lysosome",null,null,7,7,7,22,22,22,"51.853",0,"17.921",94136000,11,"0.928735",1,"1.38802","1.98716","sp|P53634|CATC_HUMAN;tr|H0YCY8|H0YCY8_HUMAN","sp|P53634|CATC_HUMAN;tr|H0YCY8|H0YCY8_HUMAN",1803,"P53634","CATC_HUMAN","Dipeptidyl peptidase 1",null,"CTSC"]
["19.7858",1,"19.0303","16.6614",1,"18.0086",{"$nulls":3},"ribosomal large subunit biogenesis;rRNA processing",null,"cytoplasm;nucleolus",{"$nulls":3},4,4,4,"21.1","21.1","21.1","42.07",0,"14.226",52592000,12,"0.0582043",1,"1.38205","0.168221","sp|Q9H6Y2|WDR55_HUMAN;tr|D6RGJ8|D6RGJ8_HUMAN;tr|G3V1J0|G3V1J0_HUMAN","sp|Q9H6Y2|WDR55_HUMAN;tr|D6RGJ8|D6RGJ8_HUMAN",4498,"Q9H6Y2","WDR55_HUMAN","WD repeat-containing protein 55",null,"WDR55"]
["21.5158","20.3065","20.8103","20.3279","19.0002","19.1706",{"$nulls":3},"lipid metabolic process",null,"lysosome",{"$nulls":3},8,8,8,"25.7","25.7","25.7","41.796",0,"46.092",279470000,20,"1.18869",1,"1.37795","2.52861","tr|E7EMM4|E7EMM4_HUMAN;sp|Q13510|ASAH1_HUMAN","tr|E7EMM4|E7EMM4_HUMAN;sp|Q13510|ASAH1_HUMAN",2373,"E7EMM4","E7EMM4_HUMAN",null,null,"ASAH1"]
["20.7934","19.0985","19.6573","18.066","18.6476","18.7446",{"$nulls":9},4,4,4,"22.8","22.8","22.8","25.085",0,"11.985",61918000,6,"1.18327",1,"1.36367","2.5169","tr|H7C5G1|H7C5G1_HUMAN;sp|Q2TAA2|IAH1_HUMAN;tr|C9JDY4|C9JDY4_HUMAN;tr|C9J5J2|C9J5J2_HUMAN;tr|C9JE02|C9JE02_HUMAN","tr|H7C5G1|H7C5G1_HUMAN;sp|Q2TAA2|IAH1_HUMAN",2721,"H7C5G1","H7C5G1_HUMAN",null,null,"IAH1"]
["18.8292","16.9511","19.3352","16.9835","16.631","17.4153",{"$nulls":4},"ATP binding;biotin carboxylase activity;metal ion binding","mitochondrion",{"$nulls":3},13,13,13,"33.6","33.6","33.6","68.331",0,"66.873",383310000,31,"0.831034",1,"1.36189","1.79228","tr|E9PHF7|E9PHF7_HUMAN;sp|Q96RQ3|MCCA_HUMAN;tr|F5GYT8|F5GYT8_HUMAN;tr|E9PG35|E9PG35_HUMAN;tr|G5E9X5|G5E9X5_HUMAN","tr|E9PHF7|E9PHF7_HUMAN;sp|Q96RQ3|MCCA_HUMAN;tr|F5GYT8|F5GYT8_HUMAN;tr|E9PG35|E9PG35_HUMAN;tr|G5E9X5|G5E9X5_HUMAN",4022,"E9PHF7","E9PHF7_HUMAN",null,null,"MCCC1"]
["19.4245","19.5543","21.2886","19.2658","16.5584","20.3614",{"$nulls":3},"chromatin silencing","DNA binding;protein heterodimerization activity","extracellular exosome;nuclear chromatin;nucleosome;nucleus","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,6,1,0,"55.5","22.7",0,"13.936",0,"83.902",632290000,21,"0.458762",1,"1.36058","1.06293","sp|Q99878|H2A1J_HUMAN;sp|Q96KK5|H2A1H_HUMAN;sp|Q9BTM1|H2AJ_HUMAN;sp|Q93077|H2A1C_HUMAN;sp|Q7L7L0|H2A3_HUMAN;sp|P20671|H2A1D_HUMAN;sp|P0C0S8|H2A1_HUMAN;sp|P04908|H2A1B_HUMAN;tr|H0YFX9|H0YFX9_HUMAN;sp|P16104|H2AX_HUMAN","sp|Q99878|H2A1J_HUMAN;sp|Q96KK5|H2A1H_HUMAN;sp|Q9BTM1|H2AJ_HUMAN;sp|Q93077|H2A1C_HUMAN;sp|Q7L7L0|H2A3_HUMAN;sp|P20671|H2A1D_HUMAN;sp|P0C0S8|H2A1_HUMAN;sp|P04908|H2A1B_HUMAN;tr|H0YFX9|H0YFX9_HUMAN;sp|P16104|H2AX_HUMAN",885,"Q99878","H2A1J_HUMAN","Histone H2A type 1-J",null,"HIST1H2AJ"]
["23.7557",1,"24.2127","21.6604",1,"22.2319",{"$nulls":3},"nucleosome assembly","nucleosomal DNA binding;protein heterodimerization activity","nucleosome;nucleus",{"$nulls":3},4,1,1,25,"8.1","8.1","15.43",0,"17.836",824320000,31,"0.0447626",1,"1.35868","0.131048","tr|Q5TEC6|Q5TEC6_HUMAN","tr|Q5TEC6|Q5TEC6_HUMAN",5616,"Q5TEC6","Q5TEC6_HUMAN","Histone H3 {ECO:0000256|RuleBase:RU004471}"]
["17.7585","15.9011","19.4648","16.0396","15.1642","17.8489",{"$nulls":3},"oxidative phosphorylation;regulation of transcription, DNA-templated;transcription from mitochondrial promoter","DNA polymerase processivity factor activity;RNA binding","intracellular ribonucleoprotein complex;mitochondrial matrix;mitochondrial nucleoid;mitochondrion",{"$nulls":3},8,8,8,"27.8","27.8","27.8","41.676",0,"37.26",262360000,33,"0.450237",1,"1.35726","1.04596","sp|Q96QE5|TEFM_HUMAN;tr|J3KTG7|J3KTG7_HUMAN","sp|Q96QE5|TEFM_HUMAN",4008,"Q96QE5","TEFM_HUMAN","Transcription elongation factor, mitochondrial",null,"TEFM"]
["21.3344","19.4237","19.9725","19.3902","19.0188","18.276",{"$nulls":3},"cellular protein metabolic process;fucose metabolic process;glycoside catabolic process;neutrophil degranulation;post-translational protein modification;regulation of entry of bacterium into host cell;response to bacterium","alpha-L-fucosidase activity","azurophil granule lumen;endoplasmic reticulum lumen;extracellular exosome;extracellular region;extracellular space","Other glycan degradation",null,null,8,8,8,"17.8","17.8","17.8","54.066",0,"55.158",210260000,20,"0.963182",1,"1.34855","2.0568","sp|Q9BTY2|FUCO2_HUMAN;tr|Q7Z6V2|Q7Z6V2_HUMAN","sp|Q9BTY2|FUCO2_HUMAN",4217,"Q9BTY2","FUCO2_HUMAN","Plasma alpha-L-fucosidase",null,"FUCA2"]
["17.2366","18.3893","17.2862","15.341","15.9678","17.5753",{"$nulls":3},"apoptotic process;cell cycle;mRNA splicing, via spliceosome;positive regulation of cell migration;positive regulation of cell proliferation;regulation of transcription, DNA-templated;transcription, DNA-templated","core promoter binding;ligand-dependent nuclear receptor transcription coactivator activity;RNA binding;transcription coactivator activity;transcription corepressor activity","nucleoplasm;perinuclear region of cytoplasm",{"$nulls":3},15,15,15,"14.2","14.2","14.2","132.82",0,"40.856",221850000,31,"0.812914",1,"1.34263","1.75649","sp|Q8IX12|CCAR1_HUMAN;tr|A0A0C4DGG8|A0A0C4DGG8_HUMAN;tr|F5H2E6|F5H2E6_HUMAN;tr|F5H1H2|F5H1H2_HUMAN;tr|F5H3E1|F5H3E1_HUMAN;tr|F5H7M9|F5H7M9_HUMAN;tr|H0YFJ7|H0YFJ7_HUMAN","sp|Q8IX12|CCAR1_HUMAN;tr|A0A0C4DGG8|A0A0C4DGG8_HUMAN",3315,"Q8IX12","CCAR1_HUMAN","Cell division cycle and apoptosis regulator protein 1",null,"CCAR1"]
["20.2275","19.3388","21.2907","19.7721","15.5311","21.5266",{"$nulls":9},2,2,2,"27.7","27.7","27.7","12.586","0.0060785","2.3692",55584000,4,"0.290811",1,"1.34236","0.719001","tr|E9PMF1|E9PMF1_HUMAN;tr|E9PPI6|E9PPI6_HUMAN;tr|E9PMM8|E9PMM8_HUMAN;tr|E9PJH1|E9PJH1_HUMAN;tr|E9PIA0|E9PIA0_HUMAN;sp|Q9BUB5|MKNK1_HUMAN","tr|E9PMF1|E9PMF1_HUMAN;tr|E9PPI6|E9PPI6_HUMAN;tr|E9PMM8|E9PMM8_HUMAN;tr|E9PJH1|E9PJH1_HUMAN;tr|E9PIA0|E9PIA0_HUMAN;sp|Q9BUB5|MKNK1_HUMAN",5520,"E9PMF1"]
["20.2563","16.5396","18.5803","17.8099","15.8522","17.6876",{"$nulls":3},"negative regulation by host of symbiont molecular function;positive regulation of exocytosis;protein transport;regulation of protein localization;retrograde transport, endosome to Golgi","GDP binding;GTP binding;GTPase activity;identical protein binding","cytosol;endoplasmic reticulum membrane;extracellular exosome;late endosome;lysosome;melanosome;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane;trans-Golgi network membrane;transport vesicle","Measles",null,null,4,4,4,"28.4","28.4","28.4","22.837",0,"13.421",33056000,5,"0.465365",1,"1.34214","1.07605","sp|P51151|RAB9A_HUMAN","sp|P51151|RAB9A_HUMAN",1732,"P51151","RAB9A_HUMAN","Ras-related protein Rab-9A",null,"RAB9A"]
["23.0474","21.4672",1,"20.0899","20.4003",1,{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell cycle;cell division;clathrin coat assembly;clathrin-dependent endocytosis;intracellular protein transport;low-density lipoprotein particle clearance;low-density lipoprotein particle receptor catabolic process;membrane organization;microtubule-based movement","clathrin heavy chain binding;GTPase binding;peptide binding;protein complex binding;structural molecule activity","clathrin coat;clathrin coat of coated pit;clathrin coat of trans-Golgi network vesicle;clathrin complex;clathrin vesicle coat;clathrin-coated endocytic vesicle;cytoplasmic vesicle;cytosol;endolysosome membrane;membrane;plasma membrane;spindle;synaptic vesicle membrane;trans-Golgi network membrane","Bacterial invasion of epithelial cells;Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Huntington disease;Lysosome;Synaptic vesicle cycle",null,null,4,4,4,"10.9","10.9","10.9","27.076","0.0026677","2.9128",255310000,2,"0.0480345",1,"1.34146","0.14018","sp|P09496|CLCA_HUMAN;tr|F8WF69|F8WF69_HUMAN;tr|C9J8P9|C9J8P9_HUMAN","sp|P09496|CLCA_HUMAN;tr|F8WF69|F8WF69_HUMAN",991,"P09496","CLCA_HUMAN","Clathrin light chain A","ca","CLTA"]
["17.9316","17.4879","20.4016","16.5916","17.4163","17.7918",{"$nulls":9},6,6,6,"11.3","11.3","11.3","73.041",0,"11.566",121530000,15,"0.618992",1,"1.34049","1.37739","tr|F8W9X7|F8W9X7_HUMAN;sp|Q567U6|CCD93_HUMAN;tr|H7C050|H7C050_HUMAN","tr|F8W9X7|F8W9X7_HUMAN;sp|Q567U6|CCD93_HUMAN",2792,"F8W9X7","F8W9X7_HUMAN",null,null,"CCDC93"]
["18.4195","15.573","18.4337","17.7227","12.6641","18.0385",{"$nulls":3},"maturation of SSU-rRNA;rRNA processing","RNA binding","cytosol;nucleolus;nucleoplasm;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,23,23,23,"38.9","38.9","38.9","87.977",0,"118.14",656740000,81,"0.268962",1,"1.33361","0.672148","sp|Q9BVJ6|UT14A_HUMAN;tr|X6RJY0|X6RJY0_HUMAN;sp|Q5TAP6|UT14C_HUMAN","sp|Q9BVJ6|UT14A_HUMAN",4252,"Q9BVJ6","UT14A_HUMAN","U3 small nucleolar RNA-associated protein 14 homolog A",null,"UTP14A"]
["22.5128","21.3503","20.7967","21.5091","18.5265","20.6244",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,2,2,2,"38.5","38.5","38.5","7.6191",0,"7.0104",164640000,20,"0.583749",1,"1.33324","1.30868","sp|O75394|RM33_HUMAN","sp|O75394|RM33_HUMAN",582,"O75394","RM33_HUMAN","39S ribosomal protein L33, mitochondrial","33mt;RP-L33","MRPL33"]
["25.5972","24.4608","23.8419","23.808","22.6431","23.4546",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;oxidation-reduction process;oxidative phosphorylation;protein processing;response to activity;response to alkaloid","metalloendopeptidase activity;protein complex binding;ubiquinol-cytochrome-c reductase activity;ubiquitin protein ligase binding;zinc ion binding","cytosol;mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrial respiratory chain complex III;mitochondrion;myelin sheath","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,22,22,21,"55.8","55.8","54.4","52.645",0,"294.11",4119100000,165,"1.00933",1,"1.33137","2.15098","sp|P31930|QCR1_HUMAN","sp|P31930|QCR1_HUMAN",1410,"P31930","QCR1_HUMAN","Cytochrome b-c1 complex subunit 1, mitochondrial",null,"UQCRC1"]
["17.0154","15.3934","14.3137","15.9914","12.4065","14.3414",{"$nulls":3},"cilium assembly;platelet degranulation;positive regulation of smooth muscle cell proliferation;prostaglandin secretion;response to drug;response to organic cyclic compound;response to organonitrogen compound;transmembrane transport","15-hydroxyprostaglandin dehydrogenase (NAD+) activity;ATP binding;ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;ATPase activity, coupled to transmembrane movement of substances;ATPase-coupled anion transmembrane transporter activity","basolateral plasma membrane;integral component of plasma membrane;membrane;plasma membrane;platelet dense granule membrane","ABC transporters;Antifolate resistance;Bile secretion;cAMP signaling pathway",null,null,6,6,6,"6.8","6.8","6.8","149.52",0,"8.9593",35788000,9,"0.437949",1,"1.32773","1.02144","sp|O15439|MRP4_HUMAN","sp|O15439|MRP4_HUMAN",377,"O15439","MRP4_HUMAN","Multidrug resistance-associated protein 4",null,"ABCC4"]
["24.7347","22.4614","22.6009","22.257","21.1146","22.4454",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA processing;mRNA splicing, via spliceosome;positive regulation of protein targeting to mitochondrion;regulation of autophagy of mitochondrion;RNA export from nucleus;RNA splicing;termination of RNA polymerase II transcription","metal ion binding;pre-mRNA 3'-splice site binding;RNA binding","Cajal body;catalytic step 2 spliceosome;nuclear speck;nucleoplasm;spliceosomal complex;U2AF","Shigellosis;Spliceosome",null,null,9,9,9,"48.3","48.3","48.3","27.872",0,"187.04",1346300000,65,"0.717877",1,"1.3267","1.5701","sp|Q01081|U2AF1_HUMAN;sp|Q8WU68|U2AF4_HUMAN;tr|M0QYK5|M0QYK5_HUMAN;tr|M0R2N4|M0R2N4_HUMAN;tr|K7EJH3|K7EJH3_HUMAN;tr|K7EJM7|K7EJM7_HUMAN","sp|Q01081|U2AF1_HUMAN",2127,"Q01081","U2AF1_HUMAN","Splicing factor U2AF 35 kDa subunit",null,"U2AF1"]
["23.2764","20.4282","17.2186","18.7223","19.5632","18.6581",{"$nulls":3},"apoptotic process;autophagosome maturation;cell cycle;cell separation after cytokinesis;endosomal transport;macroautophagy;multivesicular body assembly;multivesicular body sorting pathway;multivesicular body-lysosome fusion;negative regulation of viral release from host cell;positive regulation of viral release from host cell;protein heterooligomerization;protein polymerization;protein transport;regulation of centrosome duplication;regulation of early endosome to late endosome transport;regulation of viral process;viral budding via host ESCRT complex;viral life cycle","identical protein binding;phosphatidylcholine binding;protein homodimerization activity;ubiquitin-specific protease binding","cytoplasmic vesicle;cytosol;ESCRT III complex;extracellular exosome;intracellular;late endosome;late endosome membrane;plasma membrane","Endocytosis;Necroptosis",null,null,3,3,3,"13.5","13.5","13.5","25.073","0.00081867","3.951",129730000,3,"0.304401",1,"1.32656","0.747827","sp|Q9Y3E7|CHMP3_HUMAN","sp|Q9Y3E7|CHMP3_HUMAN",5297,"Q9Y3E7","CHMP3_HUMAN","Charged multivesicular body protein 3",null,"CHMP3"]
["20.0922","17.9751","19.4433","17.886","17.0737","18.5722",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;interferon-gamma-mediated signaling pathway;regulation of immune response;type I interferon signaling pathway;viral process","peptide antigen binding","cell surface;early endosome membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},11,2,2,"40.3","9.4","9.4","40.274","0.00021575","5.0783",88877000,7,"0.805468",1,"1.32624","1.74181","sp|P30466|1B18_HUMAN","sp|P30466|1B18_HUMAN",1383,"P30466","1B18_HUMAN","HLA class I histocompatibility antigen, B-18 alpha chain",null,"HLA-B"]
["24.379","23.3403","23.6957","22.748","22.5225","22.1675",{"$nulls":3},"hemopoiesis;positive regulation of cell proliferation","zinc ion binding","cell cortex",{"$nulls":3},8,8,8,"53.8","53.8","53.8","22.492",0,"76.827",961270000,49,"1.7204",1,"1.32563","3.80407","sp|P52943|CRIP2_HUMAN;tr|H0YFA4|H0YFA4_HUMAN;tr|H0YHD8|H0YHD8_HUMAN","sp|P52943|CRIP2_HUMAN;tr|H0YFA4|H0YFA4_HUMAN;tr|H0YHD8|H0YHD8_HUMAN",1787,"P52943","CRIP2_HUMAN","Cysteine-rich protein 2","RP-2","CRIP2"]
["23.9498","22.2867","22.6798","22.0298","21.5263","21.3902",{"$nulls":3},"C21-steroid hormone biosynthetic process;cholesterol metabolic process;generation of precursor metabolites and energy;oxidation-reduction process;steroid biosynthetic process;sterol metabolic process;ubiquinone biosynthetic process","ferredoxin-NADP+ reductase activity;NADPH-adrenodoxin reductase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},30,30,2,"67.2","67.2","4.9","53.836",0,"247.97",1841800000,98,"1.15623",1,"1.32335","2.45874","sp|P22570|ADRO_HUMAN;tr|J3KS64|J3KS64_HUMAN","sp|P22570|ADRO_HUMAN",1246,"P22570","ADRO_HUMAN","NADPH:adrenodoxin oxidoreductase, mitochondrial","drenodoxin reductase;R","FDXR"]
["23.0312","20.8837","21.1231","20.4008","19.9739","20.6996",{"$nulls":3},"malate transmembrane transport;mitochondrial transport;oxaloacetate transport;phosphate ion transmembrane transport;succinate transmembrane transport;sulfate transport;thiosulfate transport;translation","antiporter activity;malate transmembrane transporter activity;oxaloacetate transmembrane transporter activity;structural constituent of ribosome;succinate transmembrane transporter activity;sulfate transmembrane transporter activity;thiosulfate transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane;mitochondrion;nucleoplasm;ribosome",{"$nulls":3},11,11,3,"37.8","37.8","15.8","48.099",0,"148.69",1072600000,93,"0.863836",1,"1.32122","1.85732","tr|B4DLN1|B4DLN1_HUMAN;sp|P52815|RM12_HUMAN;tr|F6QW41|F6QW41_HUMAN","tr|B4DLN1|B4DLN1_HUMAN",5478,"B4DLN1","B4DLN1_HUMAN"]
["22.0357","18.1114",1,"18.1541","18.0301",1,{"$nulls":9},1,1,1,"29.7","29.7","29.7","7.0202","0.0024904","2.9832",20656000,1,"0.0528005",1,"1.32095","0.153384","tr|B8ZZF8|B8ZZF8_HUMAN;sp|Q9Y4Y9|LSM5_HUMAN","tr|B8ZZF8|B8ZZF8_HUMAN;sp|Q9Y4Y9|LSM5_HUMAN",5337,"B8ZZF8","B8ZZF8_HUMAN",null,null,"LSM5"]
["20.659","20.6681","20.7882","19.2887","20.0478","18.8248",{"$nulls":3},"box H/ACA snoRNA 3'-end processing;cell proliferation;mRNA pseudouridine synthesis;positive regulation of establishment of protein localization to telomere;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;regulation of telomerase RNA localization to Cajal body;RNA processing;rRNA processing;rRNA pseudouridine synthesis;snRNA pseudouridine synthesis;telomerase RNA stabilization;telomere maintenance via telomerase","box H/ACA snoRNA binding;pseudouridine synthase activity;RNA binding;telomerase activity;telomerase RNA binding","box H/ACA scaRNP complex;box H/ACA snoRNP complex;box H/ACA telomerase RNP complex;cytoplasm;fibrillar center;nucleolus;nucleoplasm;nucleus;telomerase holoenzyme complex","Ribosome biogenesis in eukaryotes",null,null,18,18,18,"40.1","40.1","40.1","57.673",0,"71.446",1115300000,97,"1.6707",1,"1.31801","3.67244","sp|O60832|DKC1_HUMAN;tr|C9IYT0|C9IYT0_HUMAN;tr|H7C0M1|H7C0M1_HUMAN;tr|H7C2Q9|H7C2Q9_HUMAN;tr|H7BZF2|H7BZF2_HUMAN;tr|H7C2Q2|H7C2Q2_HUMAN","sp|O60832|DKC1_HUMAN;tr|C9IYT0|C9IYT0_HUMAN;tr|H7C0M1|H7C0M1_HUMAN",529,"O60832","DKC1_HUMAN","H/ACA ribonucleoprotein complex subunit 4",null,"DKC1"]
["22.0739","22.2869","21.0795","19.5811","20.2403","21.6662",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;mitochondrial translation","NADH dehydrogenase (ubiquinone) activity;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrial ribosome;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,6,6,6,"51.3","51.3","51.3","12.551",0,"38.134",337370000,22,"0.851263",1,"1.31761","1.83235","sp|O95182|NDUA7_HUMAN;tr|M0R0N0|M0R0N0_HUMAN;tr|M0R1K9|M0R1K9_HUMAN","sp|O95182|NDUA7_HUMAN;tr|M0R0N0|M0R0N0_HUMAN",719,"O95182","NDUA7_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7",null,"NDUFA7"]
["16.1868","16.3452","16.5014","15.0869","15.6651","14.3364",{"$nulls":3},"benzylpenicillin metabolic process;canalicular bile acid transport;cellular chloride ion homeostasis;cellular response to dexamethasone stimulus;cellular response to hormone stimulus;cellular response to interleukin-1;cellular response to interleukin-6;cellular response to lipopolysaccharide;cellular response to tumor necrosis factor;drug transmembrane transport;female pregnancy;mercury ion transport;prostaglandin transport;response to antineoplastic agent;response to arsenic-containing substance;response to estrogen;response to glucagon;response to heat;response to methotrexate;response to oxidative stress;thyroid hormone transport;transmembrane transport;transport","ATP binding;ATPase activity, coupled to transmembrane movement of substances;ATPase-coupled anion transmembrane transporter activity;bilirubin transmembrane transporter activity;organic anion transmembrane transporter activity;protein domain specific binding","apical plasma membrane;brush border membrane;cell surface;integral component of plasma membrane;intercellular canaliculus;plasma membrane","ABC transporters;Antifolate resistance;Bile secretion;Platinum drug resistance",null,null,20,20,19,"16.6","16.6",16,"174.21",0,"66.435",573140000,67,"1.53489",1,"1.31495","3.32721","sp|Q92887|MRP2_HUMAN","sp|Q92887|MRP2_HUMAN",3730,"Q92887","MRP2_HUMAN","Canalicular multispecific organic anion transporter 1",null,"ABCC2"]
["18.711","16.6143","17.815","17.888","13.7856","17.5373",{"$nulls":3},"apoptotic process;negative regulation of cell proliferation;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of intracellular estrogen receptor signaling pathway;negative regulation of programmed cell death;negative regulation of transcription from RNA polymerase II promoter;negative regulation of vitamin D receptor signaling pathway;transcription, DNA-templated",null,"cytoplasm;mitochondrion",{"$nulls":3},10,10,10,"15.7","15.7","15.7","91.173",0,"36.117",131540000,22,"0.380425",1,"1.30978","0.905393","sp|Q63ZY3|KANK2_HUMAN;tr|K7ERU2|K7ERU2_HUMAN;tr|K7EL48|K7EL48_HUMAN;tr|K7ES05|K7ES05_HUMAN;tr|K7EIU4|K7EIU4_HUMAN","sp|Q63ZY3|KANK2_HUMAN",2920,"Q63ZY3","KANK2_HUMAN","KN motif and ankyrin repeat domain-containing protein 2",null,"KANK2"]
["22.221","23.4754","23.7743","19.0577","23.0976","23.3917",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial oxoglutarate dehydrogenase complex;mitochondrial small ribosomal subunit;mitochondrion",{"$nulls":3},3,3,3,"44.7","44.7","44.7","11.466",0,"32.871",334860000,18,"0.370712",1,"1.30796","0.885561","sp|P82909|RT36_HUMAN;tr|D6R941|D6R941_HUMAN","sp|P82909|RT36_HUMAN",2079,"P82909","RT36_HUMAN","28S ribosomal protein S36, mitochondrial","36mt;RP-S36","MRPS36"]
["16.0775",1,"16.2276","15.3274","13.0541",1,{"$nulls":3},"signal transduction","GTPase activator activity",{"$nulls":4},9,6,6,"12.4",10,10,"116.84",0,"16.833",36832000,9,"0.0678503",1,"1.30785","0.194366","tr|G5EA48|G5EA48_HUMAN;sp|Q7Z6B7|SRGP1_HUMAN;tr|A0A075B7C8|A0A075B7C8_HUMAN","tr|G5EA48|G5EA48_HUMAN;sp|Q7Z6B7|SRGP1_HUMAN",3181,"G5EA48","G5EA48_HUMAN"]
["20.5264","19.6031","20.2069","18.8557","18.6594","18.9001",{"$nulls":3},"chromatin organization;growth;hormone metabolic process;intracellular estrogen receptor signaling pathway;positive regulation of transcription from RNA polymerase II promoter;regulation of mRNA processing;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","chromatin binding;core promoter binding;double-stranded DNA binding;RNA binding;sequence-specific DNA binding","nucleoplasm;nucleus",{"$nulls":3},8,8,8,"13.6","13.6","13.6","102.64",0,"74.846",293220000,32,"2.01737",1,"1.30708","4.65744","sp|Q15424|SAFB1_HUMAN;sp|Q14151|SAFB2_HUMAN;tr|K7ES42|K7ES42_HUMAN","sp|Q15424|SAFB1_HUMAN;sp|Q14151|SAFB2_HUMAN",2600,"Q15424","SAFB1_HUMAN","Scaffold attachment factor B1","AF-B;AF-B1","SAFB"]
["19.6568","18.0928","17.6492","17.5471","16.9459","16.9959",{"$nulls":3},"choline catabolic process;choline transport;phosphatidylcholine biosynthetic process;transmembrane transport","choline transmembrane transporter activity","extracellular exosome;integral component of membrane;membrane;mitochondrial outer membrane;mitochondrion;nucleoplasm;plasma membrane","Choline metabolism in cancer",null,null,3,3,3,"6.5","6.5","6.5","73.301",0,"10.869",63433000,5,"0.955297",1,"1.30331","2.04081","sp|Q8WWI5|CTL1_HUMAN","sp|Q8WWI5|CTL1_HUMAN",3635,"Q8WWI5","CTL1_HUMAN","Choline transporter-like protein 1",null,"SLC44A1"]
["20.8487","19.0968","17.9195","20.9291","18.241","14.807",{"$nulls":3},"autophagosome assembly;autophagy;autophagy of mitochondrion;autophagy of nucleus;C-terminal protein lipidation;macroautophagy;positive regulation of protein catabolic process;protein delipidation;protein targeting to membrane;proteolysis","cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity","cytoplasm;cytosol","Autophagy - animal;Autophagy - other",null,null,6,6,6,"21.1","21.1","21.1","44.294",0,"23.133",140570000,17,"0.263048",1,"1.29592","0.659351","sp|Q9Y4P1|ATG4B_HUMAN;tr|C9JIK8|C9JIK8_HUMAN;tr|H7C2A6|H7C2A6_HUMAN;tr|C9JQ72|C9JQ72_HUMAN;tr|F2Z2K8|F2Z2K8_HUMAN;tr|C9J3C0|C9J3C0_HUMAN;tr|H0Y2Y0|H0Y2Y0_HUMAN;tr|C9JVD5|C9JVD5_HUMAN","sp|Q9Y4P1|ATG4B_HUMAN;tr|C9JIK8|C9JIK8_HUMAN;tr|H7C2A6|H7C2A6_HUMAN;tr|C9JQ72|C9JQ72_HUMAN",5330,"Q9Y4P1","ATG4B_HUMAN","Cysteine protease ATG4B",null,"ATG4B"]
["17.3995","14.4309","16.577","15.6823","16.0132","12.8273",{"$nulls":3},"microtubule cytoskeleton organization;mitotic cytokinesis;mRNA processing;negative regulation of apoptotic process;regulation of cell cycle;regulation of mRNA splicing, via spliceosome;regulation of RNA splicing;RNA splicing","DNA binding;RNA binding;RS domain binding","nuclear speck",{"$nulls":3},15,15,15,"8.7","8.7","8.7","263.83",0,"42.291",235860000,35,"0.409145",1,"1.29491","0.963605","sp|P18583|SON_HUMAN;tr|J3QSZ5|J3QSZ5_HUMAN;tr|H7C1M2|H7C1M2_HUMAN","sp|P18583|SON_HUMAN",1179,"P18583","SON_HUMAN","Protein SON",null,"SON"]
["20.3847",1,"18.9266","17.674",1,"17.7542",{"$nulls":3},"Golgi apparatus mannose trimming;N-glycan processing;protein glycosylation","calcium ion binding;mannosidase activity;mannosyl-oligosaccharide 1,2-alpha-mannosidase activity","cytosol;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of membrane;membrane","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,8,8,8,"20.7","20.7","20.7","72.968",0,"69.988",87605000,14,"0.0533246",1,"1.29436","0.154829","sp|P33908|MA1A1_HUMAN","sp|P33908|MA1A1_HUMAN",1435,"P33908","MA1A1_HUMAN","Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA",null,"MAN1A1"]
["24.9542","22.3728","25.4447","23.2383","21.42","24.2313",{"$nulls":3},"chromatin silencing","DNA binding;protein heterodimerization activity","extracellular exosome;nuclear chromatin;nucleosome;nucleus","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,6,4,4,"53.9","46.9","46.9","13.509",0,"243.79",1224200000,62,"0.441092",1,"1.29401","1.02772","sp|Q71UI9|H2AV_HUMAN;sp|P0C0S5|H2AZ_HUMAN;tr|C9J0D1|C9J0D1_HUMAN;tr|C9J386|C9J386_HUMAN","sp|Q71UI9|H2AV_HUMAN;sp|P0C0S5|H2AZ_HUMAN;tr|C9J0D1|C9J0D1_HUMAN;tr|C9J386|C9J386_HUMAN",1005,"Q71UI9","H2AV_HUMAN","Histone H2A.V",null,"H2AFV"]
["21.6105","19.0672","20.4996","18.3215","18.7219","20.2778",{"$nulls":3},"quinone metabolic process","NADP binding;NADPH:quinone reductase activity","cytosol",{"$nulls":3},7,7,7,"26.1","26.1","26.1","38.696",0,"36.372",246600000,19,"0.608264",1,"1.28539","1.35649","sp|O95825|QORL1_HUMAN;tr|A6NMA8|A6NMA8_HUMAN;tr|A6NND8|A6NND8_HUMAN;tr|A6NHJ8|A6NHJ8_HUMAN;tr|C9JAL0|C9JAL0_HUMAN;tr|C9JQD0|C9JQD0_HUMAN;tr|A0A0C4DG14|A0A0C4DG14_HUMAN;tr|C9K0F7|C9K0F7_HUMAN;tr|F8WF64|F8WF64_HUMAN;tr|C9JZK8|C9JZK8_HUMAN;tr|H7C3I5|H7C3I5_HUMAN;tr|H7C3S0|H7C3S0_HUMAN;tr|H7C0X3|H7C0X3_HUMAN","sp|O95825|QORL1_HUMAN;tr|A6NMA8|A6NMA8_HUMAN;tr|A6NND8|A6NND8_HUMAN;tr|A6NHJ8|A6NHJ8_HUMAN;tr|C9JAL0|C9JAL0_HUMAN",798,"O95825","QORL1_HUMAN","Quinone oxidoreductase-like protein 1",null,"CRYZL1"]
["16.4321",1,"19.1754",1,"14.8062","16.9459",{"$nulls":3},"lipid metabolic process;proteolysis;regulation of lipid metabolic process","identical protein binding;peptidase activity","cytosol;mitochondrion",{"$nulls":3},7,7,7,"20.3","20.3","20.3","60.693",0,"18.388",265280000,14,"0.058951",1,"1.28512","0.170261","sp|P83111|LACTB_HUMAN","sp|P83111|LACTB_HUMAN",2088,"P83111","LACTB_HUMAN","Serine beta-lactamase-like protein LACTB, mitochondrial {ECO:0000305}",null,"LACTB"]
["17.8436","17.4332","19.2071","15.8491","15.9678","18.8117",{"$nulls":3},"bile acid biosynthetic process;fatty acid alpha-oxidation;fatty acid beta-oxidation;long-chain fatty acid import;long-chain fatty acid metabolic process;methyl-branched fatty acid metabolic process;neutrophil degranulation;very long-chain fatty acid catabolic process","ATP binding;decanoate--CoA ligase activity;enzyme binding;fatty acid transmembrane transporter activity;long-chain fatty acid-CoA ligase activity;phytanate-CoA ligase activity;pristanate-CoA ligase activity;receptor binding;very long-chain fatty acid-CoA ligase activity","endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular exosome;integral component of endoplasmic reticulum membrane;integral component of peroxisomal membrane;mitochondrion;peroxisomal membrane;plasma membrane;specific granule membrane","Insulin resistance;Peroxisome;PPAR signaling pathway",null,null,3,3,3,"6.3","6.3","6.3","70.311",0,"7.82",62094000,4,"0.508339",1,"1.28505","1.16098","sp|O14975|S27A2_HUMAN;tr|G3V1R7|G3V1R7_HUMAN","sp|O14975|S27A2_HUMAN;tr|G3V1R7|G3V1R7_HUMAN",318,"O14975","S27A2_HUMAN","Very long-chain acyl-CoA synthetase","LACS;LCS","SLC27A2"]
["18.3367","16.3344","19.2841","17.343","15.5388","17.2232",{"$nulls":3},"cerebellar Purkinje cell layer development;glycosaminoglycan catabolic process;inner ear receptor cell development;locomotor rhythm;lysosome organization;middle ear morphogenesis;nervous system development;retinal rod cell development","alpha-N-acetylglucosaminidase activity","extracellular exosome;lysosomal lumen;lysosome","Glycosaminoglycan degradation;Lysosome;Metabolic pathways",null,null,8,8,8,"18.7","18.7","18.7","82.265",0,"17.687",60022000,10,"0.541646",1,"1.28344","1.22638","sp|P54802|ANAG_HUMAN;tr|K7ENX5|K7ENX5_HUMAN","sp|P54802|ANAG_HUMAN",1826,"P54802","ANAG_HUMAN","Alpha-N-acetylglucosaminidase",null,"NAGLU"]
["22.7795","22.5755","23.225","21.4935","21.3177","21.9236",{"$nulls":3},"mRNA splicing, via spliceosome;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA processing","pre-mRNA intronic binding;RNA binding;transcription regulatory region DNA binding","cytoplasm;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus;ribonucleoprotein granule",{"$nulls":3},16,16,8,"41.6","41.6","24.4","64.132",0,"150.46",944940000,65,"2.08619",1,"1.28176","4.87334","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN;tr|M0R1W6|M0R1W6_HUMAN;tr|M0R076|M0R076_HUMAN;tr|M0QYL7|M0QYL7_HUMAN;tr|B4DVF8|B4DVF8_HUMAN","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN",1109,"P14866","HNRPL_HUMAN","Heterogeneous nuclear ribonucleoprotein L","nRNP L","HNRNPL"]
["22.4961","20.4069","21.3946","20.0781","19.8091","20.5772",{"$nulls":3},"dephosphorylation;phosphate-containing compound metabolic process;protein dephosphorylation;purine ribonucleoside monophosphate biosynthetic process","inorganic diphosphatase activity;magnesium ion binding;phosphatase activity;protein histidine phosphatase activity;protein homodimerization activity","cytosol;nuclear speck;nucleus","Oxidative phosphorylation",null,null,8,8,8,"41.5","41.5","41.5","29.165",0,"36.511",243890000,20,"0.927172",1,"1.27772","1.98401","sp|Q9H008|LHPP_HUMAN;tr|Q5T1Z0|Q5T1Z0_HUMAN","sp|Q9H008|LHPP_HUMAN;tr|Q5T1Z0|Q5T1Z0_HUMAN",4374,"Q9H008","LHPP_HUMAN","Phospholysine phosphohistidine inorganic pyrophosphate phosphatase","LHPP","LHPP"]
["17.1615","16.1698","17.667","16.2435","14.2832","16.6471",{"$nulls":3},"blastocyst growth;cell cycle arrest;cell proliferation;DNA damage checkpoint;DNA damage response, signal transduction by p53 class mediator;DNA double-strand break processing;DNA duplex unwinding;DNA replication;DNA synthesis involved in DNA repair;double-strand break repair;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;intrinsic apoptotic signaling pathway;isotype switching;meiotic cell cycle;mitotic cell cycle checkpoint;mitotic G2 DNA damage checkpoint;negative regulation of telomere capping;neuromuscular process controlling balance;positive regulation of kinase activity;positive regulation of protein autophosphorylation;positive regulation of telomere maintenance;regulation of DNA-dependent DNA replication initiation;regulation of signal transduction by p53 class mediator;strand displacement;t-circle formation;telomere maintenance;telomere maintenance via telomere trimming;telomeric 3' overhang formation","damaged DNA binding;protein N-terminus binding;transcription factor binding","cytosol;Mre11 complex;nuclear chromosome, telomeric region;nuclear inclusion body;nucleolus;nucleoplasm;nucleus;PML body;replication fork;site of double-strand break","Cellular senescence;Homologous recombination",null,null,4,4,4,"9.2","9.2","9.2","84.958",0,"8.9052",35284000,4,"0.679801",1,"1.27483","1.49584","sp|O60934|NBN_HUMAN;tr|A0A0C4DG07|A0A0C4DG07_HUMAN;tr|E2QRP0|E2QRP0_HUMAN;tr|E5RGU1|E5RGU1_HUMAN","sp|O60934|NBN_HUMAN;tr|A0A0C4DG07|A0A0C4DG07_HUMAN",538,"O60934","NBN_HUMAN","Nibrin",null,"NBN"]
["22.9528","20.3761","20.9556","20.3768","19.9788","20.1158",{"$nulls":3},"autophagosome maturation;cellular response to starvation;chaperone-mediated autophagy;lysosomal protein catabolic process;muscle cell cellular homeostasis;negative regulation of protein homooligomerization;neutrophil degranulation;platelet degranulation;protein import;protein stabilization;protein targeting;protein targeting to lysosome involved in chaperone-mediated autophagy;regulation of protein stability","enzyme binding;protein domain specific binding","autolysosome;azurophil granule membrane;chaperone-mediated autophagy translocation complex;extracellular exosome;extracellular space;ficolin-1-rich granule membrane;integral component of autophagosome membrane;late endosome;late endosome membrane;lysosomal lumen;lysosomal membrane;lysosome;membrane;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;platelet dense granule membrane;trans-Golgi network","Autophagy - animal;Lysosome;Phagosome;Tuberculosis",null,null,3,3,2,"7.1","7.1","4.9","44.96",0,"20.382",365200000,16,"0.738654",1,"1.27106","1.6107","sp|P13473|LAMP2_HUMAN","sp|P13473|LAMP2_HUMAN",1078,"P13473","LAMP2_HUMAN","Lysosome-associated membrane glycoprotein 2","AMP-2;ysosome-associated membrane protein 2","LAMP2"]
["17.9419","15.4386","16.6711","16.1893","14.7035","15.35",{"$nulls":3},"covalent chromatin modification;regulation of transcription, DNA-templated;transcription, DNA-templated","lysine-acetylated histone binding;nucleic acid binding",{"$nulls":4},12,12,12,36,36,36,"66.999",0,"64.069",309230000,23,"0.686872",1,"1.26955","1.50962","sp|Q9H8M2|BRD9_HUMAN;tr|H0YBR9|H0YBR9_HUMAN;tr|H0YAW8|H0YAW8_HUMAN;tr|H0YBF1|H0YBF1_HUMAN;tr|C9JBY0|C9JBY0_HUMAN","sp|Q9H8M2|BRD9_HUMAN",4521,"Q9H8M2","BRD9_HUMAN","Bromodomain-containing protein 9",null,"BRD9"]
["20.9459","18.3368","20.0603","19.5445","16.7272","19.2707",{"$nulls":3},"cellular protein metabolic process;nucleus organization;post-translational protein modification;regulation of lipid metabolic process",null,"endoplasmic reticulum lumen;extracellular exosome;extracellular space;Golgi apparatus;integral component of plasma membrane",{"$nulls":3},11,11,11,"27.2","27.2","27.2","45.333",0,"45.097",521520000,40,"0.464344",1,"1.26685","1.07402","sp|Q8NBJ4|GOLM1_HUMAN;tr|F8WAT9|F8WAT9_HUMAN;tr|C9JYM4|C9JYM4_HUMAN;tr|C9J941|C9J941_HUMAN","sp|Q8NBJ4|GOLM1_HUMAN",3453,"Q8NBJ4","GOLM1_HUMAN","Golgi membrane protein 1",null,"GOLM1"]
["20.1378","16.5675","18.3832","17.6503","16.3492","17.2932",{"$nulls":3},"exocyst localization;exocytosis;protein transport","cadherin binding;SNARE binding","cytosol;exocyst;Golgi apparatus;growth cone;midbody;perinuclear region of cytoplasm;secretory granule membrane",{"$nulls":3},18,18,18,"28.4","28.4","28.4","86.844",0,"75.318",751260000,95,"0.502177",1,"1.2653","1.14884","sp|O60645|EXOC3_HUMAN;tr|D6RB59|D6RB59_HUMAN;tr|H0Y995|H0Y995_HUMAN;tr|D6RBR9|D6RBR9_HUMAN","sp|O60645|EXOC3_HUMAN;tr|D6RB59|D6RB59_HUMAN",512,"O60645","EXOC3_HUMAN","Exocyst complex component 3",null,"EXOC3"]
["21.3661","19.4317","18.5559","19.8244","16.8742","18.8632",{"$nulls":9},8,8,8,"25.8","25.8","25.8","53.458",0,"41.556",163110000,21,"0.453214",1,"1.26396","1.05189","tr|J3KND1|J3KND1_HUMAN;sp|Q96ER3|SAAL1_HUMAN;tr|E9PRZ1|E9PRZ1_HUMAN;tr|E9PMD2|E9PMD2_HUMAN;tr|H0YDM3|H0YDM3_HUMAN;tr|H0YEK5|H0YEK5_HUMAN;tr|H0YCN7|H0YCN7_HUMAN;tr|E9PL53|E9PL53_HUMAN","tr|J3KND1|J3KND1_HUMAN;sp|Q96ER3|SAAL1_HUMAN;tr|E9PRZ1|E9PRZ1_HUMAN;tr|E9PMD2|E9PMD2_HUMAN",3861,"J3KND1","J3KND1_HUMAN"]
["22.6321","20.0862","20.6574","19.4219","19.4338","20.7341",{"$nulls":3},"protein import into mitochondrial matrix;protein targeting to mitochondrion","P-P-bond-hydrolysis-driven protein transmembrane transporter activity","integral component of mitochondrial inner membrane;mitochondrial inner membrane;mitochondrial inner membrane presequence translocase complex;mitochondrion;nucleoplasm",{"$nulls":3},3,3,3,"32.2","32.2","32.2","18.023",0,"46.521",87492000,12,"0.64333",1,"1.26193","1.4248","sp|Q99595|TI17A_HUMAN","sp|Q99595|TI17A_HUMAN",4085,"Q99595","TI17A_HUMAN","Mitochondrial import inner membrane translocase subunit Tim17-A",null,"TIMM17A"]
["22.0787","18.2345","22.3455","22.2918","14.4261","22.1562",{"$nulls":3},"cellular copper ion homeostasis;copper ion transport;generation of precursor metabolites and energy;mitochondrial respiratory chain complex IV assembly;negative regulation of proteasomal protein catabolic process;respiratory chain complex IV assembly","copper ion binding","host cell mitochondrial intermembrane space;mitochondrial inner membrane;mitochondrion;myofibril",{"$nulls":3},6,6,6,"25.9","25.9","25.9","33.814",0,"75.154",391230000,23,"0.162462",1,"1.26148","0.432132","sp|O75880|SCO1_HUMAN;tr|J3QL56|J3QL56_HUMAN","sp|O75880|SCO1_HUMAN;tr|J3QL56|J3QL56_HUMAN",643,"O75880","SCO1_HUMAN","Protein SCO1 homolog, mitochondrial",null,"SCO1"]
["17.7755","17.3364","16.474","17.437","15.6418","14.7243",{"$nulls":3},"calcium ion transport into cytosol;G-protein coupled receptor signaling pathway;long-term synaptic potentiation;memory;platelet activation;positive regulation of cytosolic calcium ion concentration;protein heterooligomerization;protein homooligomerization;regulation of cardiac conduction;regulation of insulin secretion;response to calcium ion;sensory perception of bitter taste;sensory perception of sweet taste;sensory perception of umami taste","calcium ion binding;calcium-release channel activity;inositol 1,3,4,5 tetrakisphosphate binding;inositol 1,4,5 trisphosphate binding;inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;inositol hexakisphosphate binding;phosphatidylinositol binding","apical part of cell;brush border;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of plasma membrane;membrane;myelin sheath;neuronal cell body;nuclear outer membrane;nucleolus;nucleoplasm;plasma membrane;platelet dense tubular network membrane;receptor complex","Aldosterone synthesis and secretion;Alzheimer disease;Apelin signaling pathway;Apoptosis;Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholinergic synapse;Circadian entrainment;Cortisol synthesis and secretion;C-type lectin receptor signaling pathway;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Insulin secretion;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;NOD-like receptor signaling pathway;Oocyte meiosis;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Phosphatidylinositol signaling system;Platelet activation;Proteoglycans in cancer;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Taste transduction;Thyroid hormone synthesis;Vascular smooth muscle contraction",null,null,10,10,10,"5.7","5.7","5.7","304.1",0,"26.016",141340000,20,"0.644487",1,"1.26093","1.42705","sp|Q14573|ITPR3_HUMAN","sp|Q14573|ITPR3_HUMAN",2483,"Q14573","ITPR3_HUMAN","Inositol 1,4,5-trisphosphate receptor type 3",null,"ITPR3"]
["19.3276","16.0301","17.0955","17.3667","14.1924","17.1136",{"$nulls":3},"endocytosis;intracellular protein transport",null,"AP-1 adaptor complex;cytoplasm;Golgi apparatus",{"$nulls":3},6,6,6,"7.8","7.8","7.8","140.65",0,"13.811",118570000,17,"0.375437",1,"1.26011","0.895219","sp|Q9UMZ2|SYNRG_HUMAN;tr|A0A087WZS7|A0A087WZS7_HUMAN","sp|Q9UMZ2|SYNRG_HUMAN",5145,"Q9UMZ2","SYNRG_HUMAN","Synergin gamma",null,"SYNRG"]
["22.1416","21.4298","22.251","21.964","18.3032","21.777",{"$nulls":5},"integral component of membrane;mitochondrion;nucleoplasm",{"$nulls":3},3,3,3,"18.1","18.1","18.1","20.038",0,"8.2471",223320000,17,"0.444321",1,"1.25943","1.03416","tr|E7EWP0|E7EWP0_HUMAN;sp|O43674|NDUB5_HUMAN;tr|H0Y886|H0Y886_HUMAN","tr|E7EWP0|E7EWP0_HUMAN;sp|O43674|NDUB5_HUMAN;tr|H0Y886|H0Y886_HUMAN",441,"E7EWP0","E7EWP0_HUMAN",null,null,"NDUFB5"]
["19.04","18.6649","17.3111","16.8653","16.6461","17.7414",{"$nulls":3},"neutrophil degranulation;signal transduction","cytokine activity;growth factor activity;RNA binding","azurophil granule lumen;endoplasmic reticulum;endosome;extracellular exosome;extracellular region;lysosome",{"$nulls":3},4,4,4,"8.3","8.3","8.3","63.544",0,"8.2593",47252000,5,"0.942382",1,"1.2544","2.01469","sp|P28799|GRN_HUMAN;tr|K7EKL3|K7EKL3_HUMAN;tr|K7EQ05|K7EQ05_HUMAN;tr|K7EMR1|K7EMR1_HUMAN","sp|P28799|GRN_HUMAN;tr|K7EKL3|K7EKL3_HUMAN;tr|K7EQ05|K7EQ05_HUMAN",1347,"P28799","GRN_HUMAN","Granulins",null,"GRN"]
["21.5334","18.9835","17.4695","18.4874","18.2079","17.528",{"$nulls":3},"endocytic recycling;endosome organization;Golgi ribbon formation;Golgi vesicle transport;intracellular protein transport;regulation of cellular protein localization;regulation of protein localization;retrograde transport, endosome to Golgi;vesicle docking;vesicle fusion","SNAP receptor activity;syntaxin binding","clathrin-coated vesicle;cytosol;early endosome;Golgi apparatus;Golgi membrane;integral component of membrane;integral component of synaptic vesicle membrane;nucleoplasm;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;SNARE complex;terminal bouton;trans-Golgi network;trans-Golgi network membrane","SNARE interactions in vesicular transport",null,null,4,4,4,"32.2","32.2","32.2","29.176",0,"29.2",83036000,11,"0.441519",1,"1.25436","1.02857","sp|O43752|STX6_HUMAN","sp|O43752|STX6_HUMAN",450,"O43752","STX6_HUMAN","Syntaxin-6",null,"STX6"]
["21.1503","18.1142","16.521","17.8857","17.5911","16.5542",{"$nulls":3},"cellular response to tumor necrosis factor;ceramide biosynthetic process;glycerophospholipid catabolic process;glycosphingolipid metabolic process;sphingomyelin catabolic process","metal ion binding;sphingomyelin phosphodiesterase activity;sphingomyelin phosphodiesterase D activity","endoplasmic reticulum;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;integral component of membrane;trans-Golgi network","Metabolic pathways;Sphingolipid metabolism",null,null,7,7,7,"8.8","8.8","8.8","93.351",0,"9.8276",190650000,10,"0.369702",1,"1.25155","0.883495","sp|Q9NXE4|NSMA3_HUMAN;tr|H7C1Q6|H7C1Q6_HUMAN;tr|H7BXF4|H7BXF4_HUMAN;tr|B1PBA3|B1PBA3_HUMAN;tr|H7C0W5|H7C0W5_HUMAN;tr|H7C235|H7C235_HUMAN;tr|H7C2J2|H7C2J2_HUMAN;tr|F8WF03|F8WF03_HUMAN;tr|F2Z2I0|F2Z2I0_HUMAN;tr|F2Z2W5|F2Z2W5_HUMAN;tr|C9J647|C9J647_HUMAN;tr|H7C2E2|H7C2E2_HUMAN","sp|Q9NXE4|NSMA3_HUMAN;tr|H7C1Q6|H7C1Q6_HUMAN;tr|H7BXF4|H7BXF4_HUMAN;tr|B1PBA3|B1PBA3_HUMAN;tr|H7C0W5|H7C0W5_HUMAN;tr|H7C235|H7C235_HUMAN",4823,"Q9NXE4","NSMA3_HUMAN","Sphingomyelin phosphodiesterase 4",null,"SMPD4"]
["25.8436","24.4687","24.5576","23.9852","23.4509","23.6845",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;autophagy;collagen catabolic process;neutrophil degranulation;protein catabolic process;proteolysis","aspartic-type endopeptidase activity;cysteine-type endopeptidase activity;serine-type endopeptidase activity","extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;lysosomal lumen;lysosome;melanosome;membrane raft;specific granule lumen;tertiary granule lumen","Apoptosis;Autophagy - animal;Estrogen signaling pathway;Lysosome;Sphingolipid signaling pathway;Tuberculosis",null,null,17,17,17,"47.1","47.1","47.1","44.552",0,"307.63",3895800000,154,"1.24739",1,"1.24977","2.65689","sp|P07339|CATD_HUMAN;tr|C9JH19|C9JH19_HUMAN;tr|H7C469|H7C469_HUMAN;tr|H7C1V0|H7C1V0_HUMAN;tr|F8WD96|F8WD96_HUMAN;tr|F8W787|F8W787_HUMAN","sp|P07339|CATD_HUMAN;tr|C9JH19|C9JH19_HUMAN;tr|H7C469|H7C469_HUMAN",934,"P07339","CATD_HUMAN","Cathepsin D",null,"CTSD"]
["14.9728","16.4286","16.3145","11.8076","15.2168","16.9424",{"$nulls":3},"histone acetylation","kinase activity","Golgi apparatus;histone acetyltransferase complex;nucleoplasm",{"$nulls":3},47,47,0,"16.2","16.2",0,"436.13",0,"175.23",676920000,100,"0.325081",1,"1.24969","0.791269","tr|F2Z2U4|F2Z2U4_HUMAN","tr|F2Z2U4|F2Z2U4_HUMAN",5526,"F2Z2U4","F2Z2U4_HUMAN",null,null,"TRRAP"]
["25.1782","25.158","24.7143","24.2187","23.3265","23.7618",{"$nulls":3},"cellular protein localization;cellular response to hypoxia;establishment or maintenance of microtubule cytoskeleton polarity;IRE1-mediated unfolded protein response;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;muscle organ development;negative regulation of cardiac muscle hypertrophy in response to stress;negative regulation of cell proliferation;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of mesenchymal cell proliferation;negative regulation of release of cytochrome c from mitochondria;nuclear envelope organization;positive regulation of cell aging;protein localization to nucleus;regulation of cell migration;regulation of protein localization to nucleus;regulation of telomere maintenance;sterol regulatory element binding protein import into nucleus;ventricular cardiac muscle cell development","identical protein binding;structural molecule activity","cytosol;extracellular matrix;intermediate filament;lamin filament;nuclear envelope;nuclear lamina;nuclear membrane;nuclear speck;nucleoplasm;nucleus;perinuclear region of cytoplasm","Apoptosis;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM)",null,null,41,41,40,"58.6","58.6","58.6","74.139",0,"323.31",9549300000,366,"1.8553",1,"1.24783","4.17681","sp|P02545|LMNA_HUMAN;tr|Q3BDU5|Q3BDU5_HUMAN;tr|Q5TCI8|Q5TCI8_HUMAN;tr|H0YAB0|H0YAB0_HUMAN;tr|A0A0C4DGC5|A0A0C4DGC5_HUMAN","sp|P02545|LMNA_HUMAN;tr|Q3BDU5|Q3BDU5_HUMAN;tr|Q5TCI8|Q5TCI8_HUMAN",849,"P02545","LMNA_HUMAN","Prelamin-A/C",null,"LMNA"]
["21.288","20.2113","21.0256","20.6147","18.4225","19.7529",{"$nulls":3},"protein N-linked glycosylation via arginine",null,"integral component of membrane;oligosaccharyltransferase complex",{"$nulls":3},1,1,1,"12.5","12.5","12.5","14.678","0.00042194","4.5975",95549000,14,"0.804813",1,"1.24499","1.74052","sp|Q8N6L1|KTAP2_HUMAN","sp|Q8N6L1|KTAP2_HUMAN",3425,"Q8N6L1","KTAP2_HUMAN","Keratinocyte-associated protein 2","CP-2","KRTCAP2"]
["21.6777","17.5671","19.9231","20.4829","15.7069","19.2493",{"$nulls":3},"chaperone-mediated protein folding;protein folding","calcium ion binding;FK506 binding;peptidyl-prolyl cis-trans isomerase activity","cytoplasm;endoplasmic reticulum",{"$nulls":3},8,8,8,"16.3","16.3","16.3","63.083",0,"29.144",225980000,17,"0.266827",1,"1.24295","0.667533","sp|O95302|FKBP9_HUMAN;tr|C9J4P8|C9J4P8_HUMAN;sp|Q75LS8|FKB9L_HUMAN","sp|O95302|FKBP9_HUMAN",740,"O95302","FKBP9_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP9","PIase FKBP9","FKBP9"]
["22.7797","21.2906","22.6421","21.5803","20.3956","21.0378",{"$nulls":3},"platelet aggregation","RNA binding;zinc ion binding","extracellular exosome;focal adhesion;nucleus",{"$nulls":3},4,4,4,"29.5","29.5","29.5","20.567",0,"18.944",512230000,28,"0.986992",1,"1.23288","2.10525","sp|P21291|CSRP1_HUMAN;tr|E9PND2|E9PND2_HUMAN;tr|E9PP21|E9PP21_HUMAN;tr|E9PS42|E9PS42_HUMAN","sp|P21291|CSRP1_HUMAN;tr|E9PND2|E9PND2_HUMAN;tr|E9PP21|E9PP21_HUMAN;tr|E9PS42|E9PS42_HUMAN",1223,"P21291","CSRP1_HUMAN","Cysteine and glycine-rich protein 1",null,"CSRP1"]
["21.5523","21.1391","18.6293","18.5794","20.99","18.0659",{"$nulls":3},"positive regulation of ubiquitin-protein transferase activity;post-translational protein modification;protein neddylation","cullin family protein binding;ubiquitin conjugating enzyme binding;ubiquitin-like protein binding","cytosol;nucleus;ubiquitin ligase complex",{"$nulls":3},6,6,6,"27.8","27.8","27.8","30.124",0,"106.15",184640000,23,"0.406042",1,"1.22845","0.957344","sp|Q96GG9|DCNL1_HUMAN;tr|C9JVE2|C9JVE2_HUMAN;tr|C9J8R4|C9J8R4_HUMAN;tr|C9JRU6|C9JRU6_HUMAN;tr|C9J0B2|C9J0B2_HUMAN;tr|C9JUW4|C9JUW4_HUMAN;tr|F8WC32|F8WC32_HUMAN","sp|Q96GG9|DCNL1_HUMAN;tr|C9JVE2|C9JVE2_HUMAN;tr|C9J8R4|C9J8R4_HUMAN;tr|C9JRU6|C9JRU6_HUMAN;tr|C9J0B2|C9J0B2_HUMAN;tr|C9JUW4|C9JUW4_HUMAN",3897,"Q96GG9","DCNL1_HUMAN","DCN1-like protein 1",null,"DCUN1D1"]
["23.0051","22.3344","22.0287","21.3083","20.8612","21.5274",{"$nulls":3},"ATP transport;cellular response to calcium ion;cellular response to oxidative stress;mitochondrial transport;regulation of cell death","ADP transmembrane transporter activity;ATP transmembrane transporter activity;calcium ion binding","integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},21,21,21,"51.8","51.8","51.8","53.354",0,"90.651",1027500000,82,"1.60775",1,"1.22377","3.50989","sp|Q6NUK1|SCMC1_HUMAN;tr|J3KN42|J3KN42_HUMAN;tr|H3BMI3|H3BMI3_HUMAN","sp|Q6NUK1|SCMC1_HUMAN",2977,"Q6NUK1","SCMC1_HUMAN","Calcium-binding mitochondrial carrier protein SCaMC-1",null,"SLC25A24"]
["21.5977","18.9987",1,"19.4148","17.5231",1,{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of androgen receptor activity;regulation of transcription from RNA polymerase II promoter","DNA binding transcription factor activity;ligand-dependent nuclear receptor transcription coactivator activity;nuclear hormone receptor binding","nucleoplasm;nucleus;spliceosomal complex","Spliceosome",null,null,4,4,4,"25.7","25.7","25.7",17,0,"17.498",82916000,12,"0.0478811",1,"1.21952","0.139753","sp|P41223|BUD31_HUMAN;tr|C9JNV2|C9JNV2_HUMAN;tr|F8WCN7|F8WCN7_HUMAN;tr|C9JCD9|C9JCD9_HUMAN","sp|P41223|BUD31_HUMAN;tr|C9JNV2|C9JNV2_HUMAN",1532,"P41223","BUD31_HUMAN","Protein BUD31 homolog",null,"BUD31"]
["23.5502","21.7491","22.2084","21.6245","20.4764","21.7494",{"$nulls":3},"carbohydrate biosynthetic process;CMP-N-acetylneuraminate biosynthetic process","N-acetylneuraminate synthase activity;N-acylneuraminate cytidylyltransferase activity;N-acylneuraminate-9-phosphate synthase activity","cytoplasm;cytosol;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,10,10,10,"44.8","44.8","44.8","40.307",0,"92.034",703070000,33,"0.837575",1,"1.2191","1.80522","sp|Q9NR45|SIAS_HUMAN;tr|Q5TBR1|Q5TBR1_HUMAN;tr|Q5TBR0|Q5TBR0_HUMAN","sp|Q9NR45|SIAS_HUMAN",4678,"Q9NR45","SIAS_HUMAN","Sialic acid synthase",null,"NANS"]
["24.0018","24.6157","24.2279","24.2162","20.8372","24.1388",{"$nulls":3},"generation of precursor metabolites and energy;mitochondrial electron transport, cytochrome c to oxygen","cytochrome-c oxidase activity","integral component of membrane;mitochondrial inner membrane;mitochondrion","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,3,3,3,"29.3","29.3","29.3","8.7813",0,"7.5922",1120200000,38,"0.467132",1,"1.21775","1.07955","sp|P09669|COX6C_HUMAN","sp|P09669|COX6C_HUMAN",998,"P09669","COX6C_HUMAN","Cytochrome c oxidase subunit 6C",null,"COX6C"]
["20.6289","17.741","20.1673","18.1631","17.3047","19.4176",{"$nulls":4},"GTPase activator activity",{"$nulls":4},3,3,3,"19.2","19.2","19.2","20.147",0,"7.7246",70255000,3,"0.48819",1,"1.21725","1.12125","tr|D6RBS5|D6RBS5_HUMAN;sp|Q8IZ81|ELMD2_HUMAN;tr|V9GY58|V9GY58_HUMAN;tr|D6RHX2|D6RHX2_HUMAN","tr|D6RBS5|D6RBS5_HUMAN;sp|Q8IZ81|ELMD2_HUMAN;tr|V9GY58|V9GY58_HUMAN",3352,"D6RBS5","D6RBS5_HUMAN",null,null,"ELMOD2"]
["19.6971","17.1776","20.2725","18.668","16.9449","17.8936",{"$nulls":5},"nucleoplasm",{"$nulls":3},3,3,3,"20.7","20.7","20.7","22.703",0,"8.6975",49106000,9,"0.493112",1,"1.2136","1.13097","tr|G3V4C6|G3V4C6_HUMAN;sp|Q9Y224|CN166_HUMAN;tr|H0YJB9|H0YJB9_HUMAN;tr|G3V4E7|G3V4E7_HUMAN","tr|G3V4C6|G3V4C6_HUMAN;sp|Q9Y224|CN166_HUMAN;tr|H0YJB9|H0YJB9_HUMAN",5197,"G3V4C6","G3V4C6_HUMAN",null,null,"RTRAF"]
["19.7814","18.8441","19.354","18.644","17.7702","17.9416",{"$nulls":3},"signal transduction","GTPase activator activity","cytosol;nucleoplasm",{"$nulls":3},17,17,14,"22.1","22.1","19.7","120.74",0,"89.73",444230000,54,"1.47195",1,"1.20792","3.17387","tr|B7ZM87|B7ZM87_HUMAN;tr|A2RUF3|A2RUF3_HUMAN;sp|O75044|SRGP2_HUMAN;tr|A0A075B7B5|A0A075B7B5_HUMAN;sp|P0DMP2|SRG2B_HUMAN;sp|P0DJJ0|SRG2C_HUMAN;tr|Q5VZB4|Q5VZB4_HUMAN;tr|A0A075B743|A0A075B743_HUMAN;tr|A0A075B7E6|A0A075B7E6_HUMAN;tr|E9PDX4|E9PDX4_HUMAN;tr|A0A075B7E9|A0A075B7E9_HUMAN;tr|A0A087WW56|A0A087WW56_HUMAN;tr|A0A087X0L1|A0A087X0L1_HUMAN;tr|A0A087X1G6|A0A087X1G6_HUMAN","tr|B7ZM87|B7ZM87_HUMAN;tr|A2RUF3|A2RUF3_HUMAN;sp|O75044|SRGP2_HUMAN;tr|A0A075B7B5|A0A075B7B5_HUMAN",541,"B7ZM87","B7ZM87_HUMAN"]
["18.1564","17.5847","16.9608","16.8848","17.7524","14.4539",{"$nulls":5},"bicellular tight junction;nucleus;plasma membrane","Tight junction",null,null,14,14,14,"20.6","20.6","20.6","101.4",0,"41.37",519650000,45,"0.503212",1,"1.20361","1.15088","sp|O95049|ZO3_HUMAN;tr|K7ESC0|K7ESC0_HUMAN","sp|O95049|ZO3_HUMAN",705,"O95049","ZO3_HUMAN","Tight junction protein ZO-3",null,"TJP3"]
["24.0131","21.243","21.0565","21.4531","20.4253","20.8268",{"$nulls":5},"integral component of membrane",{"$nulls":3},5,5,5,"32.8","32.8","32.8","21.127",0,"155.03",454100000,35,"0.52842",1,"1.20243","1.20045","tr|Q5T8U5|Q5T8U5_HUMAN;sp|O15260|SURF4_HUMAN;tr|B7Z1G8|B7Z1G8_HUMAN","tr|Q5T8U5|Q5T8U5_HUMAN;sp|O15260|SURF4_HUMAN;tr|B7Z1G8|B7Z1G8_HUMAN",354,"Q5T8U5","Q5T8U5_HUMAN"]
["21.0409","20.83","20.3557","20.0551","18.8716","19.6977",{"$nulls":3},"apoptotic process;cellular response to leukemia inhibitory factor;negative regulation of transcription, DNA-templated;positive regulation of apoptotic process;positive regulation of DNA-templated transcription, initiation;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of response to DNA damage stimulus;regulation of DNA-templated transcription in response to stress;transcription, DNA-templated","DNA binding;RNA binding","cytoplasm;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},14,13,13,"18.6","17.4","17.4","106.12",0,"74.251",561300000,58,"1.38405",1,"1.20075","2.96618","sp|Q9NYF8|BCLF1_HUMAN;tr|E9PK91|E9PK91_HUMAN;tr|E9PK09|E9PK09_HUMAN;tr|E9PQN2|E9PQN2_HUMAN;tr|E9PKI6|E9PKI6_HUMAN;tr|E9PJA7|E9PJA7_HUMAN;tr|H0YF14|H0YF14_HUMAN;tr|H0YF00|H0YF00_HUMAN;tr|H0YF63|H0YF63_HUMAN","sp|Q9NYF8|BCLF1_HUMAN;tr|E9PK91|E9PK91_HUMAN;tr|E9PK09|E9PK09_HUMAN;tr|E9PQN2|E9PQN2_HUMAN;tr|E9PKI6|E9PKI6_HUMAN;tr|E9PJA7|E9PJA7_HUMAN",4850,"Q9NYF8","BCLF1_HUMAN","Bcl-2-associated transcription factor 1","tf","BCLAF1"]
["19.9316","19.131","19.222","19.2592","17.1486","18.2751",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear mRNA surveillance;nuclear polyadenylation-dependent mRNA catabolic process;nuclear polyadenylation-dependent rRNA catabolic process;nuclear polyadenylation-dependent tRNA catabolic process;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';regulation of mRNA stability;RNA catabolic process;rRNA processing;U1 snRNA 3'-end processing;U4 snRNA 3'-end processing;U5 snRNA 3'-end processing","3'-5'-exoribonuclease activity;AU-rich element binding;RNA binding","cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);nuclear exosome (RNase complex);nucleolus;nucleoplasm","RNA degradation",null,null,4,4,4,"16.5","16.5","16.5","31.821",0,"14.596",86124000,15,"0.844292",1,"1.20055","1.81852","sp|Q15024|EXOS7_HUMAN","sp|Q15024|EXOS7_HUMAN",2541,"Q15024","EXOS7_HUMAN","Exosome complex component RRP42",null,"EXOSC7"]
["22.184","21.6439","21.0629","20.9353","20.08","20.2741",{"$nulls":3},"mRNA 3'-splice site recognition;mRNA processing;mRNA splicing, via spliceosome;positive regulation of neuron projection development;RNA splicing","RNA binding;zinc ion binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;small nuclear ribonucleoprotein complex;spliceosomal complex;U2 snRNP;U2-type prespliceosome","Spliceosome",null,null,7,7,7,"21.1","21.1","21.1","49.255",0,"36.445",360100000,26,"1.35373",1,"1.20045","2.89621","sp|Q15428|SF3A2_HUMAN;tr|K7EMT0|K7EMT0_HUMAN","sp|Q15428|SF3A2_HUMAN",2602,"Q15428","SF3A2_HUMAN","Splicing factor 3A subunit 2",null,"SF3A2"]
["17.69","19.3072","21.4268","17.8446","18.5679","18.411",{"$nulls":3},"establishment of endothelial intestinal barrier;negative regulation of cell migration;neutrophil degranulation;positive regulation of protein autophosphorylation;Rap protein signal transduction;regulation of protein tyrosine kinase activity","GDP binding;GTP binding;GTPase activity;transcription coactivator activity","bicellular tight junction;cell-cell contact zone;cytoplasm;cytosol;extracellular exosome;plasma membrane;recycling endosome membrane;tertiary granule membrane","Tight junction",null,null,5,1,1,"31.1","4.9","4.9","20.745","0.0053813","2.461",150100000,5,"0.470936",1,"1.20017","1.0871","sp|Q9Y3L5|RAP2C_HUMAN;tr|A0A087X2C3|A0A087X2C3_HUMAN","sp|Q9Y3L5|RAP2C_HUMAN",5302,"Q9Y3L5","RAP2C_HUMAN","Ras-related protein Rap-2c",null,"RAP2C"]
["20.1762","16.6835","18.5266","17.1428","16.5747","18.0683",{"$nulls":3},"histone H3-K4 methylation",null,"Set1C/COMPASS complex",{"$nulls":3},7,7,7,"19.4","19.4","19.4","55.324",0,"24.718",152500000,21,"0.473585",1,"1.20014","1.09235","tr|F5H8F7|F5H8F7_HUMAN;sp|Q9UBL3|ASH2L_HUMAN;tr|H0YBF6|H0YBF6_HUMAN;tr|H0YAQ0|H0YAQ0_HUMAN","tr|F5H8F7|F5H8F7_HUMAN;sp|Q9UBL3|ASH2L_HUMAN",4960,"F5H8F7","F5H8F7_HUMAN",null,null,"ASH2L"]
["23.4105","21.4208","24.4135","22.2137","21.6567","21.7834",{"$nulls":3},"intracellular protein transport;organelle assembly;organelle localization;positive regulation of receptor localization to synapse;positive regulation of T cell mediated cytotoxicity;regulation of protein localization to plasma membrane;vesicle docking;vesicle fusion","chloride channel inhibitor activity;SNAP receptor activity;SNARE binding;syntaxin binding","azurophil granule;early endosome;early endosome membrane;endocytic vesicle;endosome;extracellular exosome;immunological synapse;integral component of membrane;late endosome;lysosomal membrane;lysosome;perinuclear region of cytoplasm;plasma membrane;recycling endosome;SNARE complex;tertiary granule;vesicle","Phagosome;SNARE interactions in vesicular transport",null,null,10,10,10,"49.8","49.8","49.8","29.815",0,"84.487",742270000,45,"0.598138",1,"1.19698","1.33675","sp|O15400|STX7_HUMAN","sp|O15400|STX7_HUMAN",375,"O15400","STX7_HUMAN","Syntaxin-7",null,"STX7"]
["20.5906","21.006","20.9192","19.7415","19.9239","19.2618",{"$nulls":3},"anastral spindle assembly;astral microtubule organization;cell division;chromosome segregation;establishment of mitotic spindle orientation;meiotic cell cycle;microtubule bundle formation;nucleus organization;positive regulation of BMP signaling pathway;positive regulation of chromosome segregation;positive regulation of chromosome separation;positive regulation of hair follicle development;positive regulation of intracellular transport;positive regulation of keratinocyte differentiation;positive regulation of microtubule polymerization;positive regulation of mitotic spindle elongation;positive regulation of protein localization to cell cortex;positive regulation of protein localization to spindle pole body;positive regulation of spindle assembly;regulation of metaphase plate congression;regulation of mitotic spindle organization","disordered domain specific binding;dynein complex binding;microtubule binding;microtubule minus-end binding;microtubule plus-end binding;phosphatidylinositol binding;protein complex binding;protein C-terminus binding;protein domain specific binding;structural molecule activity;tubulin binding","cell cortex;cell cortex region;centrosome;chromosome;cortical microtubule;cytoplasmic microtubule bundle;cytosol;dendrite;extracellular exosome;extrinsic component of plasma membrane;Golgi membrane;lateral cell cortex;lateral plasma membrane;microtubule bundle;microtubule minus-end;microtubule plus-end;mitotic spindle;mitotic spindle astral microtubule;mitotic spindle midzone;mitotic spindle pole;neuronal cell body;nuclear matrix;nucleoplasm;nucleus;protein complex;spindle;spindle microtubule;spindle pole;spindle pole centrosome",{"$nulls":3},61,61,61,"41.2","41.2","41.2","238.26",0,"323.31",2539400000,259,"2.15635",1,"1.19619","5.10122","sp|Q14980|NUMA1_HUMAN;tr|A0A087WY61|A0A087WY61_HUMAN;tr|H0YFY6|H0YFY6_HUMAN;tr|F5H4J1|F5H4J1_HUMAN;tr|F5H6Y5|F5H6Y5_HUMAN;tr|K4DIE0|K4DIE0_HUMAN;tr|F5H763|F5H763_HUMAN;tr|F5H0Z7|F5H0Z7_HUMAN;tr|F5H2F3|F5H2F3_HUMAN;tr|F5H3L6|F5H3L6_HUMAN;tr|F5H1L0|F5H1L0_HUMAN;tr|F5GZW1|F5GZW1_HUMAN;tr|F5H7R5|F5H7R5_HUMAN;tr|F5H4Y4|F5H4Y4_HUMAN;tr|F5GWA2|F5GWA2_HUMAN;tr|F5GWK2|F5GWK2_HUMAN;tr|F5H073|F5H073_HUMAN;tr|F5H068|F5H068_HUMAN;tr|F8W6T3|F8W6T3_HUMAN","sp|Q14980|NUMA1_HUMAN;tr|A0A087WY61|A0A087WY61_HUMAN",2520,"Q14980","NUMA1_HUMAN","Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}",null,"NUMA1"]
["21.8239","20.9401","21.519","20.6519","19.197","20.8542",{"$nulls":3},"cellular response to retinoic acid;cellular response to transforming growth factor beta stimulus;cellular response to tumor necrosis factor;mRNA processing;mRNA splicing, via spliceosome;negative regulation of chaperone-mediated autophagy;negative regulation of protein refolding;positive regulation of mRNA splicing, via spliceosome;regulation of ATPase activity;regulation of RNA splicing;RNA splicing","mRNA binding;RNA binding;U1 snRNA binding;U1 snRNP binding","commitment complex;cytoplasm;nuclear speck;nucleoplasm;nucleus;precatalytic spliceosome;spliceosomal complex;U1 snRNP;U2-type prespliceosome","Spliceosome",null,null,11,11,11,"34.8","34.8","34.8","51.556",0,"56.451",797350000,48,"0.958649",1,"1.19329","2.0476","sp|P08621|RU17_HUMAN;tr|M0QYR1|M0QYR1_HUMAN;tr|M0QX04|M0QX04_HUMAN","sp|P08621|RU17_HUMAN",969,"P08621","RU17_HUMAN","U1 small nuclear ribonucleoprotein 70 kDa","1 snRNP 70 kDa;1-70K;nRNP70","SNRNP70"]
["24.4778","22.9754","23.5504","23.1626","21.742","22.5239",{"$nulls":3},"cellular response to glucagon stimulus;G-protein coupled receptor signaling pathway;protein folding","calcium channel regulator activity;GTPase activity;GTPase binding;protein complex binding;signal transducer activity","cell body;cytosol;extracellular exosome;extracellular space;focal adhesion;lysosomal membrane;membrane;myelin sheath;perinuclear region of cytoplasm;plasma membrane;protein complex;vesicle","Alcoholism;Apelin signaling pathway;Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Dopaminergic synapse;GABAergic synapse;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Morphine addiction;Pathways in cancer;PI3K-Akt signaling pathway;Ras signaling pathway;Relaxin signaling pathway;Retrograde endocannabinoid signaling;Serotonergic synapse",null,null,13,13,8,"51.2","51.2","32.9","37.331",0,"246.8",1628000000,61,"0.927837",1,"1.19169","1.98535","sp|P62879|GBB2_HUMAN;tr|C9JXA5|C9JXA5_HUMAN;tr|C9JIS1|C9JIS1_HUMAN;tr|C9JZN1|C9JZN1_HUMAN;tr|E7EP32|E7EP32_HUMAN;sp|Q9HAV0|GBB4_HUMAN;tr|C9JD14|C9JD14_HUMAN;tr|H7C5J5|H7C5J5_HUMAN","sp|P62879|GBB2_HUMAN;tr|C9JXA5|C9JXA5_HUMAN;tr|C9JIS1|C9JIS1_HUMAN;tr|C9JZN1|C9JZN1_HUMAN;tr|E7EP32|E7EP32_HUMAN",2004,"P62879","GBB2_HUMAN","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2",null,"GNB2"]
["19.3105",1,"18.8721","16.0211",1,"18.5885",{"$nulls":3},"brain development;glycosylation;lysosomal lumen acidification;neurogenesis;neuron maturation;positive regulation of GTP binding;protein catabolic process;retrograde transport, endosome to Golgi;signal peptide processing","mannose binding","cytosol;endoplasmic reticulum;extracellular exosome;Golgi apparatus;integral component of membrane;lysosomal membrane;lysosome;perinuclear region of cytoplasm","Lysosome",null,null,3,3,3,"8.1","8.1","8.1","41.496","0.00021683","5.2357",48857000,4,"0.0501608",1,"1.19102","0.146085","sp|O75503|CLN5_HUMAN;tr|A0A024R644|A0A024R644_HUMAN;tr|A0A087WZY0|A0A087WZY0_HUMAN","sp|O75503|CLN5_HUMAN;tr|A0A024R644|A0A024R644_HUMAN",599,"O75503","CLN5_HUMAN","Ceroid-lipofuscinosis neuronal protein 5","rotein CLN5","CLN5"]
["21.331","19.4207","18.6091","20.2294","18.149","17.4233",{"$nulls":3},"carbohydrate metabolic process","beta-N-acetylhexosaminidase activity;N-acetyl-beta-D-galactosaminidase activity",{"$nulls":4},7,7,7,"16.9","16.9","16.9","58.44",0,"20.819",167860000,12,"0.436241",1,"1.18635","1.01802","tr|H3BS10|H3BS10_HUMAN;sp|P06865|HEXA_HUMAN;tr|H3BP20|H3BP20_HUMAN;tr|H3BU85|H3BU85_HUMAN;tr|H3BTD4|H3BTD4_HUMAN","tr|H3BS10|H3BS10_HUMAN;sp|P06865|HEXA_HUMAN;tr|H3BP20|H3BP20_HUMAN;tr|H3BU85|H3BU85_HUMAN;tr|H3BTD4|H3BTD4_HUMAN",924,"H3BS10","H3BS10_HUMAN","Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093}",null,"HEXA"]
["18.9476","15.996","17.8147","18.8981","13.9299","16.3777",{"$nulls":3},"neutrophil degranulation","ATP binding","ficolin-1-rich granule membrane;mitochondrial inner membrane;mitochondrion;plasma membrane;secretory granule membrane",{"$nulls":3},22,4,2,"37.8","9.4","4.3","72.572",0,"21.419",130430000,17,"0.285736",1,"1.18419","0.708175","sp|Q5T9A4|ATD3B_HUMAN","sp|Q5T9A4|ATD3B_HUMAN",2879,"Q5T9A4","ATD3B_HUMAN","ATPase family AAA domain-containing protein 3B",null,"ATAD3B"]
["20.499","19.5195","20.4849","20.0215","16.9737","19.9565",{"$nulls":3},"activation of phospholipase D activity;adenylate cyclase-activating G-protein coupled receptor signaling pathway;branching involved in blood vessel morphogenesis;cell differentiation;G-protein coupled receptor signaling pathway;in utero embryonic development;movement of cell or subcellular component;platelet activation;positive regulation of apoptotic process;positive regulation of cytosolic calcium ion concentration;regulation of cell migration;regulation of cell shape;regulation of small GTPase mediated signal transduction;Rho protein signal transduction;signal transduction","D5 dopamine receptor binding;G-protein beta/gamma-subunit complex binding;GTP binding;GTPase activity;guanyl-nucleotide exchange factor activity;metal ion binding;Rho guanyl-nucleotide exchange factor activity;signal transducer activity;type 1 angiotensin receptor binding","brush border membrane;cytosol;extracellular exosome;focal adhesion;heterotrimeric G-protein complex;melanosome;membrane;nucleus;plasma membrane","Apelin signaling pathway;cGMP-PKG signaling pathway;Human cytomegalovirus infection;Long-term depression;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;Phospholipase D signaling pathway;Platelet activation;Regulation of actin cytoskeleton;Sphingolipid signaling pathway;Vascular smooth muscle contraction",null,null,8,8,8,26,26,26,"44.049",0,"36.501",268680000,31,"0.488014",1,"1.18396","1.1209","sp|Q14344|GNA13_HUMAN","sp|Q14344|GNA13_HUMAN",2468,"Q14344","GNA13_HUMAN","Guanine nucleotide-binding protein subunit alpha-13"," alpha-13;-protein subunit alpha-13","GNA13"]
["21.9876","21.2493","21.7414","19.8595","19.9446","21.6375",{"$nulls":3},"cellular response to hypoxia;heterochromatin organization;nucleosome assembly;regulation of cell proliferation;regulation of nucleus size;regulation of transcription, DNA-templated","DNA binding;nucleosome binding","chromosome;nuclear speck;nucleosome;nucleus",{"$nulls":3},19,19,19,"43.8","43.8","43.8","61.206",0,"148.32",3784300000,215,"0.888503",1,"1.17885","1.90648","sp|Q5SSJ5|HP1B3_HUMAN;tr|X6RGJ2|X6RGJ2_HUMAN;tr|B0QZK4|B0QZK4_HUMAN;tr|Q5SWC8|Q5SWC8_HUMAN;tr|B0QZK8|B0QZK8_HUMAN;tr|B0QZK9|B0QZK9_HUMAN","sp|Q5SSJ5|HP1B3_HUMAN;tr|X6RGJ2|X6RGJ2_HUMAN;tr|B0QZK4|B0QZK4_HUMAN;tr|Q5SWC8|Q5SWC8_HUMAN",2849,"Q5SSJ5","HP1B3_HUMAN","Heterochromatin protein 1-binding protein 3",null,"HP1BP3"]
["22.0772","19.9942","21.3323","20.1243","19.1879","20.556",{"$nulls":3},"angiogenesis involved in wound healing;blood coagulation, intrinsic pathway;energy homeostasis;glucose homeostasis;negative regulation of systemic arterial blood pressure;neutrophil degranulation;plasma kallikrein-kinin cascade;proteolysis;regulation of blood vessel endothelial cell migration;regulation of reactive oxygen species metabolic process;regulation of thyroid hormone mediated signaling pathway","dipeptidyl-peptidase activity;serine-type carboxypeptidase activity","azurophil granule membrane;basal part of cell;extracellular exosome;ficolin-1-rich granule membrane;plasma membrane","Protein digestion and absorption;Renin-angiotensin system",null,null,6,6,6,"16.7","16.7","16.7","55.799",0,"76.645",312830000,23,"0.739408",1,"1.17853","1.61217","sp|P42785|PCP_HUMAN;tr|E9PNF7|E9PNF7_HUMAN;tr|E9PL49|E9PL49_HUMAN;tr|E9PLY4|E9PLY4_HUMAN;tr|E9PQB5|E9PQB5_HUMAN;tr|E9PL85|E9PL85_HUMAN;tr|E9PNJ1|E9PNJ1_HUMAN;tr|E9PQN3|E9PQN3_HUMAN;tr|E9PKN6|E9PKN6_HUMAN;tr|E9PIG4|E9PIG4_HUMAN","sp|P42785|PCP_HUMAN",1561,"P42785","PCP_HUMAN","Lysosomal Pro-X carboxypeptidase",null,"PRCP"]
["21.3227","19.9103","20.6545","19.7961","18.6291","19.9279",{"$nulls":3},"protein folding","cyclosporin A binding;peptidyl-prolyl cis-trans isomerase activity","cytoplasm;extracellular exosome",{"$nulls":3},2,2,2,"9.9","9.9","9.9","22.763",0,"5.6894",123980000,11,"0.950024",1,"1.17809","2.03013","sp|P45877|PPIC_HUMAN","sp|P45877|PPIC_HUMAN",1577,"P45877","PPIC_HUMAN","Peptidyl-prolyl cis-trans isomerase C","PIase C","PPIC"]
["25.2018","23.6834","23.3494","23.4807","22.4291","22.803",{"$nulls":3},"intracellular cholesterol transport",null,"intracellular",{"$nulls":3},7,7,7,"56.1","56.1","56.1","16.23",0,"35.83",1143700000,40,"0.841048",1,"1.17393","1.8121","tr|J3KMY5|J3KMY5_HUMAN;sp|P61916|NPC2_HUMAN;tr|G3V3E8|G3V3E8_HUMAN;tr|E7EMS2|E7EMS2_HUMAN;tr|G3V3D1|G3V3D1_HUMAN;tr|H0YIZ1|H0YIZ1_HUMAN;tr|G3V2V8|G3V2V8_HUMAN","tr|J3KMY5|J3KMY5_HUMAN;sp|P61916|NPC2_HUMAN;tr|G3V3E8|G3V3E8_HUMAN;tr|E7EMS2|E7EMS2_HUMAN;tr|G3V3D1|G3V3D1_HUMAN;tr|H0YIZ1|H0YIZ1_HUMAN;tr|G3V2V8|G3V2V8_HUMAN",1941,"J3KMY5","J3KMY5_HUMAN",null,null,"NPC2"]
["20.4559","19.7112","20.0856","18.3088","19.1551","19.2686",{"$nulls":3},"cellular response to stimulus;oligodendrocyte development;regulation of molecular function;response to glucose;response to heat;response to peptide hormone;translational initiation","identical protein binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex;membrane;plasma membrane","Herpes simplex virus 1 infection;RNA transport",null,null,12,12,12,"44.9","44.9","44.9","33.712",0,"34.987",288450000,38,"1.46614",1,"1.17341","3.15991","sp|Q14232|EI2BA_HUMAN;tr|F5H0D0|F5H0D0_HUMAN;tr|H0YGG4|H0YGG4_HUMAN","sp|Q14232|EI2BA_HUMAN;tr|F5H0D0|F5H0D0_HUMAN",2457,"Q14232","EI2BA_HUMAN","Translation initiation factor eIF-2B subunit alpha",null,"EIF2B1"]
["18.5385","17.0614","18.1176","20.5395","11.8387","17.8289",{"$nulls":3},"fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA dehydrogenase","acyl-CoA dehydrogenase activity;flavin adenine dinucleotide binding;hydrolase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},8,8,8,"11.1","11.1","11.1","118.83",0,"31.73",210690000,15,"0.169485",1,"1.1701","0.448696","sp|Q6JQN1|ACD10_HUMAN;tr|F8W1I9|F8W1I9_HUMAN;tr|F8W1A9|F8W1A9_HUMAN;tr|D6RFF6|D6RFF6_HUMAN;tr|F8VXK4|F8VXK4_HUMAN;tr|F8W0Q4|F8W0Q4_HUMAN;tr|F8W179|F8W179_HUMAN","sp|Q6JQN1|ACD10_HUMAN;tr|F8W1I9|F8W1I9_HUMAN",2968,"Q6JQN1","ACD10_HUMAN","Acyl-CoA dehydrogenase family member 10","CAD-10","ACAD10"]
["24.0936","23.1688","23.6046","22.7113","22.2174","22.432",{"$nulls":3},"embryonic camera-type eye development;embryonic eye morphogenesis;face development;Harderian gland development;inner ear morphogenesis;locomotory behavior;neuromuscular process controlling balance;nucleus accumbens development;olfactory pit development;optic cup morphogenesis involved in camera-type eye development;positive regulation of apoptotic process;protein homotetramerization;retinal metabolic process;retinoic acid biosynthetic process;retinoic acid metabolic process;retinol metabolic process;righting reflex","aldehyde dehydrogenase (NAD) activity;aldehyde dehydrogenase [NAD(P)+] activity;NAD+ binding;protein homodimerization activity;retinal dehydrogenase activity;thyroid hormone binding","cytoplasm;cytosol;extracellular exosome;nucleus;plasma membrane","beta-Alanine metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Glycolysis / Gluconeogenesis;Histidine metabolism;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Phenylalanine metabolism;Tyrosine metabolism",null,null,27,27,23,"55.9","55.9","50.4","56.108",0,"210.1",2434700000,131,"1.74023",1,"1.16877","3.85741","sp|P47895|AL1A3_HUMAN;tr|H0Y2X5|H0Y2X5_HUMAN;tr|H0YKF9|H0YKF9_HUMAN;tr|H0YNQ3|H0YNQ3_HUMAN;tr|H0YLT1|H0YLT1_HUMAN","sp|P47895|AL1A3_HUMAN;tr|H0Y2X5|H0Y2X5_HUMAN",1614,"P47895","AL1A3_HUMAN","Aldehyde dehydrogenase family 1 member A3",null,"ALDH1A3"]
["18.7616","17.1013","19.2531","15.617","16.7454","19.262",{"$nulls":3},"signal transduction",null,"cytoplasm;cytosol;plasma membrane",{"$nulls":3},5,4,4,"13.4","11.5","11.5","59.241",0,"29.464",107630000,9,"0.389866",1,"1.16384","0.924595","sp|Q9BTT6|LRRC1_HUMAN;tr|Q5T0G3|Q5T0G3_HUMAN","sp|Q9BTT6|LRRC1_HUMAN",4210,"Q9BTT6","LRRC1_HUMAN","Leucine-rich repeat-containing protein 1",null,"LRRC1"]
["21.5161","21.281","20.985","19.4979","19.7929","21.0088",{"$nulls":3},"blood coagulation;negative regulation of G0 to G1 transition;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;viral process","chromatin binding;histone deacetylase binding;identical protein binding;macromolecular complex binding;methylated histone binding;protein binding, bridging;protein homodimerization activity;repressing transcription factor binding;ribonucleoprotein complex binding","chromocenter;histone deacetylase complex;histone methyltransferase complex;kinetochore;macromolecular complex;nuclear chromosome, telomeric region;nuclear envelope;nuclear heterochromatin;nuclear pericentric heterochromatin;nucleolus;nucleoplasm;nucleus;pericentric heterochromatin;ribonucleoprotein complex;transcriptional repressor complex",{"$nulls":3},4,4,4,"23.6","23.6","23.6","22.225",0,"7.081",187840000,12,"1.12044",1,"1.16083","2.38252","sp|P45973|CBX5_HUMAN;tr|F8VNY3|F8VNY3_HUMAN","sp|P45973|CBX5_HUMAN;tr|F8VNY3|F8VNY3_HUMAN",1580,"P45973","CBX5_HUMAN","Chromobox protein homolog 5",null,"CBX5"]
["20.0674","18.822","20.1044","19.9715","17.576","17.9661",{"$nulls":3},"acylglycerol metabolic process;CDP-diacylglycerol biosynthetic process;hematopoietic progenitor cell differentiation;phosphatidic acid biosynthetic process;phospholipid biosynthetic process","1-acylglycerol-3-phosphate O-acyltransferase activity","endoplasmic reticulum membrane;integral component of membrane;mitochondrial outer membrane;mitochondrion;nuclear envelope","Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phospholipase D signaling pathway",null,null,7,7,7,"22.5","22.5","22.5","42.072",0,"75.612",425800000,35,"0.609702",1,"1.16005","1.35929","sp|Q9NUQ2|PLCE_HUMAN;tr|H0YC22|H0YC22_HUMAN;tr|E5RH21|E5RH21_HUMAN","sp|Q9NUQ2|PLCE_HUMAN",4737,"Q9NUQ2","PLCE_HUMAN","1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon",null,"AGPAT5"]
["20.5652","17.4251","19.2697","18.3379","16.2968","19.1508",{"$nulls":3},"mRNA splicing, via spliceosome;neutrophil degranulation;positive regulation of viral genome replication;protein folding;regulation of transcription, DNA-templated;transcription-coupled nucleotide-excision repair","cyclosporin A binding;peptidyl-prolyl cis-trans isomerase activity;RNA binding","catalytic step 2 spliceosome;cytosol;extracellular region;ficolin-1-rich granule lumen;nuclear speck;nucleoplasm;nucleus;secretory granule lumen","Spliceosome",null,null,6,5,5,"31.6","29.2","29.2","33.43",0,"13.857",90439000,10,"0.392542",1,"1.15815","0.930025","sp|Q9UNP9|PPIE_HUMAN;tr|E9PKY5|E9PKY5_HUMAN;tr|E9PEQ6|E9PEQ6_HUMAN;tr|E9PIB0|E9PIB0_HUMAN;tr|E9PK21|E9PK21_HUMAN","sp|Q9UNP9|PPIE_HUMAN;tr|E9PKY5|E9PKY5_HUMAN;tr|E9PEQ6|E9PEQ6_HUMAN",5159,"Q9UNP9","PPIE_HUMAN","Peptidyl-prolyl cis-trans isomerase E","PIase E","PPIE"]
["20.5269","19.7996","19.8752","19.2267","18.6347","18.8708",{"$nulls":3},"bicellular tight junction assembly",null,"bicellular tight junction;integral component of membrane",{"$nulls":3},7,7,7,"18.6","18.6","18.6","59.129",0,"30.979",158700000,19,"1.79847",1,"1.15651","4.01694","tr|A0A0G2JMZ8|A0A0G2JMZ8_HUMAN;sp|Q16625|OCLN_HUMAN","tr|A0A0G2JMZ8|A0A0G2JMZ8_HUMAN;sp|Q16625|OCLN_HUMAN",2678,"A0A0G2JMZ8","A0A0G2JMZ8_HUMAN",null,null,"OCLN"]
["19.32","18.5077","19.4989","17.4572","17.3346","19.0679",{"$nulls":3},"cis assembly of pre-catalytic spliceosome;mRNA splicing, via spliceosome;RNA secondary structure unwinding;RNA splicing;RNA splicing, via transesterification reactions","ATP binding;ATP-dependent RNA helicase activity;RNA binding","catalytic step 2 spliceosome;cytoplasm;extracellular exosome;nucleolus;nucleoplasm;nucleus;U5 snRNP","Spliceosome",null,null,23,23,23,29,29,29,"95.581",0,"81.076",1134500000,127,"0.843115",1,"1.15563","1.81619","sp|Q9BUQ8|DDX23_HUMAN;tr|H0YI52|H0YI52_HUMAN;tr|F8VVA2|F8VVA2_HUMAN","sp|Q9BUQ8|DDX23_HUMAN",4234,"Q9BUQ8","DDX23_HUMAN","Probable ATP-dependent RNA helicase DDX23",null,"DDX23"]
["17.9697","16.8766","17.771","17.3993","15.0577","16.7001",{"$nulls":3},"positive regulation of proteasomal protein catabolic process;response to endoplasmic reticulum stress",null,"endoplasmic reticulum;integral component of membrane",{"$nulls":3},7,7,7,"8.7","8.7","8.7","104.01",0,"10.736",189620000,23,"0.679749",1,"1.15341","1.49574","sp|Q6ZXV5|TMTC3_HUMAN;tr|F8VRY4|F8VRY4_HUMAN;tr|F8VR71|F8VR71_HUMAN;tr|F8W044|F8W044_HUMAN","sp|Q6ZXV5|TMTC3_HUMAN",3093,"Q6ZXV5","TMTC3_HUMAN","Transmembrane and TPR repeat-containing protein 3",null,"TMTC3"]
["23.8606","22.3397","22.9964","21.9055","21.5215","22.3101",{"$nulls":3},"AMP metabolic process;blood coagulation;GTP metabolic process;ITP metabolic process;UTP metabolic process","ATP binding;GTP binding;nucleoside triphosphate adenylate kinase activity","mitochondrial matrix;mitochondrion","Purine metabolism",null,null,15,15,15,"67.4","67.4","67.4","25.565",0,"86.837",1048400000,51,"1.09362",1,"1.15316","2.32597","sp|Q9UIJ7|KAD3_HUMAN","sp|Q9UIJ7|KAD3_HUMAN",5053,"Q9UIJ7","KAD3_HUMAN","GTP:AMP phosphotransferase AK3, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03169}",null,"AK3"]
["24.1286","22.2116","22.9623","22.4812","21.1113","22.2608",{"$nulls":3},"cell adhesion;cellular defense response;platelet degranulation;signal transduction","scavenger receptor activity","blood microparticle;extracellular exosome;extracellular matrix;extracellular region;extracellular space;membrane;platelet dense granule lumen;proteinaceous extracellular matrix",{"$nulls":3},14,14,14,"35.9","35.9","35.9","65.33",0,"240.89",1754200000,85,"0.753704",1,"1.14974","1.64015","sp|Q08380|LG3BP_HUMAN;tr|K7EP36|K7EP36_HUMAN;tr|K7ESM3|K7ESM3_HUMAN;tr|K7EKQ5|K7EKQ5_HUMAN;tr|K7ERZ6|K7ERZ6_HUMAN;tr|K7EJY8|K7EJY8_HUMAN;tr|K7EJD3|K7EJD3_HUMAN;tr|K7ES75|K7ES75_HUMAN;tr|K7EN99|K7EN99_HUMAN","sp|Q08380|LG3BP_HUMAN",2232,"Q08380","LG3BP_HUMAN","Galectin-3-binding protein",null,"LGALS3BP"]
["19.2079","17.0847",1,1,"16.1927","16.6544",{"$nulls":9},1,1,1,"6.5","6.5","6.5","24.974","0.001003","3.5989",22966000,1,"0.0511801",1,"1.14853","0.148907","tr|H0YHD0|H0YHD0_HUMAN;sp|Q5PSV4|BRM1L_HUMAN","tr|H0YHD0|H0YHD0_HUMAN;sp|Q5PSV4|BRM1L_HUMAN",2838,"H0YHD0","H0YHD0_HUMAN",null,null,"BRMS1L"]
["22.3499","20.6314","21.0131","21.0712","19.3422","20.1386",{"$nulls":3},"circadian rhythm;mRNA destabilization;mRNA processing;mRNA splicing, via spliceosome;negative regulation of catalytic activity;RNA metabolic process","mRNA 3'-UTR binding;RNA binding","axon terminus;catalytic step 2 spliceosome;dendrite;endoplasmic reticulum;growth cone;intracellular ribonucleoprotein complex;nucleoplasm;spliceosomal complex",{"$nulls":3},20,15,15,"41.5",34,34,"70.942",0,"83.008",709780000,55,"0.727879",1,"1.14748","1.58963","sp|O43390|HNRPR_HUMAN;tr|B4DT28|B4DT28_HUMAN","sp|O43390|HNRPR_HUMAN;tr|B4DT28|B4DT28_HUMAN",413,"O43390","HNRPR_HUMAN","Heterogeneous nuclear ribonucleoprotein R","nRNP R","HNRNPR"]
["24.3308","23.1342","23.5948","22.7603","21.9319","22.928",{"$nulls":3},"ATP metabolic process;cardiac muscle contraction;cell adhesion;cell communication by electrical coupling involved in cardiac conduction;cellular calcium ion homeostasis;cellular potassium ion homeostasis;cellular sodium ion homeostasis;ion transmembrane transport;leukocyte migration;membrane repolarization;membrane repolarization during cardiac muscle cell action potential;positive regulation of ATPase activity;positive regulation of calcium:sodium antiporter activity;positive regulation of potassium ion import;positive regulation of potassium ion transmembrane transporter activity;positive regulation of sodium ion export across plasma membrane;potassium ion import;potassium ion import across plasma membrane;protein localization to plasma membrane;protein stabilization;protein transport into plasma membrane raft;regulation of cardiac conduction;regulation of cardiac muscle contraction by calcium ion signaling;regulation of gene expression;relaxation of cardiac muscle;response to hypoxia;sodium ion export across plasma membrane","ATPase activator activity;ATPase binding;MHC class II protein complex binding;protein C-terminus binding;protein kinase binding;sodium:potassium-exchanging ATPase activity","apical plasma membrane;basolateral plasma membrane;caveola;extracellular exosome;extracellular vesicle;intercalated disc;intracellular;membrane;myelin sheath;plasma membrane;sarcolemma;sodium:potassium-exchanging ATPase complex","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Aldosterone-regulated sodium reabsorption;Bile secretion;cAMP signaling pathway;Carbohydrate digestion and absorption;Cardiac muscle contraction;cGMP-PKG signaling pathway;Endocrine and other factor-regulated calcium reabsorption;Gastric acid secretion;Insulin secretion;Mineral absorption;Pancreatic secretion;Protein digestion and absorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Thyroid hormone signaling pathway;Thyroid hormone synthesis",null,null,8,8,8,"37.3","37.3","37.3","35.061",0,"81.84",1373000000,73,"1.15947",1,"1.14654","2.46568","sp|P05026|AT1B1_HUMAN;tr|V9GYR2|V9GYR2_HUMAN","sp|P05026|AT1B1_HUMAN;tr|V9GYR2|V9GYR2_HUMAN",888,"P05026","AT1B1_HUMAN","Sodium/potassium-transporting ATPase subunit beta-1",null,"ATP1B1"]
["19.6313","18.4411","18.0763","18.158","17.0095","17.5507",{"$nulls":9},5,5,5,"28.4","28.4","28.4","24.064",0,"13.888",63839000,8,"0.929743",1,"1.14349","1.98919","tr|Q5SZ82|Q5SZ82_HUMAN;tr|A0A087WXU0|A0A087WXU0_HUMAN;sp|Q9NWS8|RMND1_HUMAN","tr|Q5SZ82|Q5SZ82_HUMAN;tr|A0A087WXU0|A0A087WXU0_HUMAN;sp|Q9NWS8|RMND1_HUMAN",4793,"Q5SZ82","Q5SZ82_HUMAN",null,null,"RMND1"]
["20.2049","18.1193","19.3743","18.3104","17.1747","18.7931",{"$nulls":3},"chaperone-mediated protein folding;histone peptidyl-prolyl isomerization","calcium ion binding;FK506 binding;peptidyl-prolyl cis-trans isomerase activity","cytoplasm;endoplasmic reticulum lumen;nucleolus",{"$nulls":3},10,10,10,"21.3","21.3","21.3","64.244",0,"17.635",155360000,19,"0.668997",1,"1.14007","1.47479","sp|Q96AY3|FKB10_HUMAN;tr|H0Y827|H0Y827_HUMAN;tr|K7ESG6|K7ESG6_HUMAN;tr|K7EM43|K7EM43_HUMAN;tr|K7ELI6|K7ELI6_HUMAN","sp|Q96AY3|FKB10_HUMAN;tr|H0Y827|H0Y827_HUMAN",3796,"Q96AY3","FKB10_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP10","PIase FKBP10","FKBP10"]
["20.1363","16.6918","18.2281","16.9584","16.2048","18.4775",{"$nulls":4},"nucleic acid binding","midbody;nucleoplasm",{"$nulls":3},3,3,3,"5.8","5.8","5.8","89.054","0.0011781","3.2851",144940000,7,"0.401895",1,"1.13848","0.948966","tr|B9EGQ5|B9EGQ5_HUMAN;tr|M0QXA7|M0QXA7_HUMAN;sp|O95785|WIZ_HUMAN","tr|B9EGQ5|B9EGQ5_HUMAN;tr|M0QXA7|M0QXA7_HUMAN;sp|O95785|WIZ_HUMAN",789,"B9EGQ5","B9EGQ5_HUMAN"]
["22.8891","22.1687","21.3806","21.5505","20.76","20.721",{"$nulls":4},"4 iron, 4 sulfur cluster binding;FMN binding;metal ion binding;NAD binding;NADH dehydrogenase (ubiquinone) activity","cytosol;mitochondrial inner membrane;mitochondrion;respiratory chain",{"$nulls":3},19,19,19,"54.9","54.9","54.9","50.054",0,"97.596",835940000,56,"1.04061",1,"1.13569","2.21545","tr|G3V0I5|G3V0I5_HUMAN;sp|P49821|NDUV1_HUMAN;tr|B4DE93|B4DE93_HUMAN;tr|E9PQP1|E9PQP1_HUMAN;tr|E9PMX3|E9PMX3_HUMAN;tr|E9PLC6|E9PLC6_HUMAN;tr|E9PPR0|E9PPR0_HUMAN;tr|E9PJL9|E9PJL9_HUMAN;tr|H0YE81|H0YE81_HUMAN;tr|E9PPS5|E9PPS5_HUMAN;tr|H0YD04|H0YD04_HUMAN;tr|E9PPD6|E9PPD6_HUMAN","tr|G3V0I5|G3V0I5_HUMAN;sp|P49821|NDUV1_HUMAN;tr|B4DE93|B4DE93_HUMAN",1688,"G3V0I5","G3V0I5_HUMAN","NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial {ECO:0000256|RuleBase:RU364066}"]
["19.403","16.33","18.9048","18.5325","14.3049","18.3977",{"$nulls":9},7,7,7,"10.5","10.5","10.5","108.34",0,"63.429",166180000,24,"0.269845",1,"1.1342","0.674055","tr|A0A087X0S5|A0A087X0S5_HUMAN;sp|P12109|CO6A1_HUMAN","tr|A0A087X0S5|A0A087X0S5_HUMAN;sp|P12109|CO6A1_HUMAN",1059,"A0A087X0S5","A0A087X0S5_HUMAN",null,null,"COL6A1"]
["20.6364","18.0399","18.984","18.0894","17.5176","18.6516",{"$nulls":3},"protein folding in endoplasmic reticulum",null,"ER membrane protein complex;integral component of membrane",{"$nulls":3},11,11,11,"16.1","16.1","16.1","111.76",0,"35.453",242560000,32,"0.616289",1,"1.13389","1.37213","sp|Q8N766|EMC1_HUMAN;tr|H7C4E3|H7C4E3_HUMAN","sp|Q8N766|EMC1_HUMAN",3430,"Q8N766","EMC1_HUMAN","ER membrane protein complex subunit 1",null,"EMC1"]
["18.185","17.3005","17.2818","16.7461","14.9625","17.6609",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding",{"$nulls":4},15,15,15,"25.8","25.8","25.8","86.604",0,"111.78",629970000,65,"0.598804",1,"1.13261","1.33805","tr|B7Z6D5|B7Z6D5_HUMAN;sp|Q96GQ7|DDX27_HUMAN;tr|A0A087X059|A0A087X059_HUMAN;tr|A0A087WYH5|A0A087WYH5_HUMAN","tr|B7Z6D5|B7Z6D5_HUMAN;sp|Q96GQ7|DDX27_HUMAN",3901,"B7Z6D5","B7Z6D5_HUMAN",null,null,"DDX27"]
["23.5051","22.2294","22.0129","21.6273","21.0302","21.7115",{"$nulls":3},"apoptotic process;BMP signaling pathway;cell aging;cellular response to lipopolysaccharide;epithelial to mesenchymal transition involved in cardiac fibroblast development;interleukin-12-mediated signaling pathway;negative regulation of apoptotic process;negative regulation of cell cycle;negative regulation of cytokine production involved in inflammatory response;negative regulation of JUN kinase activity;negative regulation of myofibroblast differentiation;negative regulation of transcription, DNA-templated;negative regulation of vascular smooth muscle cell differentiation;positive regulation of endothelial cell apoptotic process;positive regulation of inflammatory response;positive regulation of NIK/NF-kappaB signaling;positive regulation of smooth muscle cell apoptotic process","RNA binding","cytoplasm;cytosol;nucleus","MicroRNAs in cancer;Proteoglycans in cancer",null,null,14,14,14,"39.9","39.9","39.9","51.735",0,"129.32",1000400000,51,"1.03181",1,"1.12615","2.19724","sp|Q53EL6|PDCD4_HUMAN;tr|Q5VZS7|Q5VZS7_HUMAN","sp|Q53EL6|PDCD4_HUMAN",2768,"Q53EL6","PDCD4_HUMAN","Programmed cell death protein 4",null,"PDCD4"]
["22.9379","21.7029","22.5709","21.6758","20.8984","21.2603",{"$nulls":3},"cardiac muscle contraction;diaphragm contraction;glucose metabolic process;glycogen catabolic process;heart morphogenesis;locomotory behavior;lysosome organization;maltose metabolic process;muscle cell cellular homeostasis;neuromuscular process controlling balance;neuromuscular process controlling posture;neutrophil degranulation;regulation of the force of heart contraction;sucrose metabolic process;tissue development;vacuolar sequestering","alpha-1,4-glucosidase activity;carbohydrate binding;maltose alpha-glucosidase activity;oligo-1,6-glucosidase activity","azurophil granule membrane;extracellular exosome;ficolin-1-rich granule membrane;lysosomal lumen;lysosomal membrane;lysosome;membrane;plasma membrane;tertiary granule membrane","Galactose metabolism;Lysosome;Metabolic pathways;Starch and sucrose metabolism",null,null,18,18,18,31,31,31,"105.32",0,"196.47",1399200000,79,"1.23098",1,"1.12573","2.62078","sp|P10253|LYAG_HUMAN;tr|I3L3L3|I3L3L3_HUMAN;tr|I3L0S5|I3L0S5_HUMAN","sp|P10253|LYAG_HUMAN",1015,"P10253","LYAG_HUMAN","Lysosomal alpha-glucosidase",null,"GAA"]
[1,"19.0672","20.7223",1,"16.0231","20.3916",{"$nulls":3},"intracellular protein transport",null,"endoplasmic reticulum;integral component of membrane",{"$nulls":3},3,3,3,"14.3","14.3","14.3","26.953",0,"17.684",97573000,12,"0.0445408",1,"1.12489","0.130427","tr|C9JTE9|C9JTE9_HUMAN;sp|Q9UHQ4|BAP29_HUMAN;tr|C9JGJ9|C9JGJ9_HUMAN;tr|F8WB99|F8WB99_HUMAN;tr|C9IYK6|C9IYK6_HUMAN;tr|H7C5E2|H7C5E2_HUMAN;tr|C9JP06|C9JP06_HUMAN;tr|F8WDG1|F8WDG1_HUMAN;tr|B7Z2L0|B7Z2L0_HUMAN;tr|H0Y7N8|H0Y7N8_HUMAN","tr|C9JTE9|C9JTE9_HUMAN;sp|Q9UHQ4|BAP29_HUMAN;tr|C9JGJ9|C9JGJ9_HUMAN;tr|F8WB99|F8WB99_HUMAN;tr|C9IYK6|C9IYK6_HUMAN;tr|H7C5E2|H7C5E2_HUMAN",5029,"C9JTE9","C9JTE9_HUMAN",null,null,"BCAP29"]
["19.4757","17.1583","19.1733","17.3626","16.6409","18.4382",{"$nulls":3},"peptide hormone processing","metalloendopeptidase activity","integral component of membrane",{"$nulls":3},7,7,7,"14.2","14.2","14.2","83.573",0,"24.805",114770000,11,"0.555206",1,"1.12184","1.25292","tr|B4DKB2|B4DKB2_HUMAN;sp|P42892|ECE1_HUMAN;tr|E9PN99|E9PN99_HUMAN;tr|E9PHZ1|E9PHZ1_HUMAN","tr|B4DKB2|B4DKB2_HUMAN;sp|P42892|ECE1_HUMAN",1562,"B4DKB2","B4DKB2_HUMAN",null,null,"ECE1"]
["22.0241","19.67","21.2598","22.4633","17.1607","19.9827",{"$nulls":3},"DNA replication;DNA replication initiation;G1/S transition of mitotic cell cycle;histone H3 acetylation;telomere maintenance via semi-conservative replication","DNA binding;DNA-directed DNA polymerase activity;protein heterodimerization activity","Ada2/Gcn5/Ada3 transcription activator complex;epsilon DNA polymerase complex;nucleoplasm;nucleus","Base excision repair;DNA replication;Nucleotide excision repair",null,null,3,3,3,"30.6","30.6","30.6","16.859",0,"60.424",192890000,14,"0.264989",1,"1.11571","0.663557","sp|Q9NRF9|DPOE3_HUMAN","sp|Q9NRF9|DPOE3_HUMAN",4688,"Q9NRF9","DPOE3_HUMAN","DNA polymerase epsilon subunit 3",null,"POLE3"]
["19.0282","17.9945","17.6351","17.6758","15.9148","17.7243",{"$nulls":3},"acyl-CoA metabolic process;fatty acid metabolic process;negative regulation of protein kinase B signaling;protein kinase B signaling;regulation of mitochondrial membrane permeability involved in apoptotic process","acyl-CoA hydrolase activity;myristoyl-CoA hydrolase activity;palmitoyl-CoA hydrolase activity","cytosol;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;plasma membrane;ruffle membrane","Fatty acid elongation;PI3K-Akt signaling pathway",null,null,2,2,2,10,10,10,"27.129","0.0028463","2.8206",24919000,2,"0.698603",1,"1.11431","1.53249","sp|Q5T1C6|THEM4_HUMAN","sp|Q5T1C6|THEM4_HUMAN",2862,"Q5T1C6","THEM4_HUMAN","Acyl-coenzyme A thioesterase THEM4","cyl-CoA thioesterase THEM4","THEM4"]
["22.0762","22.7255","22.7512","20.3735","21.8286","22.0093",{"$nulls":3},"apoptotic process;CTP biosynthetic process;GTP biosynthetic process;nucleobase-containing small molecule interconversion;regulation of apoptotic process;UTP biosynthetic process","ATP binding;metal ion binding;nucleoside diphosphate kinase activity","cytosol;extracellular exosome;intracellular;mitochondrion","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,8,8,8,"49.7","49.7","49.7","19.015",0,"28.42",411240000,35,"0.92458",1,"1.11388","1.9788","sp|Q13232|NDK3_HUMAN;tr|H3BPR2|H3BPR2_HUMAN;tr|H3BPD9|H3BPD9_HUMAN;tr|H3BMQ7|H3BMQ7_HUMAN;tr|H3BRA8|H3BRA8_HUMAN","sp|Q13232|NDK3_HUMAN;tr|H3BPR2|H3BPR2_HUMAN",2327,"Q13232","NDK3_HUMAN","Nucleoside diphosphate kinase 3","DK 3;DP kinase 3","NME3"]
["21.2685","16.4527","21.1822","18.2803","16.076","21.2128",{"$nulls":3},"cellular response to glucose stimulus;cellular response to hypoxia;excitatory postsynaptic potential;lactation;nucleobase-containing compound metabolic process;nucleoside transport;sleep;uridine transport","nucleoside transmembrane transporter activity","apical plasma membrane;basolateral plasma membrane;integral component of plasma membrane;membrane;plasma membrane;postsynapse","Alcoholism",null,null,2,2,2,"6.4","6.4","6.4","50.219",0,"47.319",175760000,14,"0.196025",1,"1.11145","0.510226","sp|Q99808|S29A1_HUMAN","sp|Q99808|S29A1_HUMAN",4111,"Q99808","S29A1_HUMAN","Equilibrative nucleoside transporter 1",null,"SLC29A1"]
["22.7211","21.5804","20.5748","19.2249","20.7302","21.6082",{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},11,11,11,"55.7","55.7","55.7","23.864",0,"194.86",2513500000,137,"0.520504",1,"1.10436","1.1849","sp|Q96EY4|TMA16_HUMAN;tr|H0Y9X1|H0Y9X1_HUMAN;tr|D6RA57|D6RA57_HUMAN;tr|D6RE67|D6RE67_HUMAN;tr|D6RC31|D6RC31_HUMAN","sp|Q96EY4|TMA16_HUMAN;tr|H0Y9X1|H0Y9X1_HUMAN;tr|D6RA57|D6RA57_HUMAN",3868,"Q96EY4","TMA16_HUMAN","Translation machinery-associated protein 16",null,"TMA16"]
["20.4361","18.0044","19.0281","18.4254","17.6288","18.1044",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;cellular response to organic substance;epithelial cell differentiation involved in prostate gland development;ganglioside GM1 transport to membrane;glycosphingolipid metabolic process;lipid transport;negative regulation of hydrogen peroxide-induced cell death;neutrophil degranulation;platelet degranulation;positive regulation of MAPK cascade;prostate gland growth;regulation of autophagy;regulation of lipid metabolic process","beta-galactosidase activity;enzyme activator activity;ganglioside GM1 binding;ganglioside GM2 binding;ganglioside GM3 binding;ganglioside GP1c binding;ganglioside GT1b binding;G-protein coupled receptor binding;identical protein binding;lipid binding;phospholipid binding;protein homodimerization activity","azurophil granule membrane;extracellular exosome;extracellular matrix;extracellular region;extracellular space;integral component of membrane;intracellular membrane-bounded organelle;lysosomal lumen;lysosomal membrane;lysosome;mitochondrion;plasma membrane","Lysosome",null,null,5,5,5,"14.3","14.3","14.3","58.112",0,"19.38",160260000,12,"0.675328",1,"1.10333","1.48712","sp|P07602|SAP_HUMAN;tr|C9JIZ6|C9JIZ6_HUMAN;tr|A0A0J9YXB8|A0A0J9YXB8_HUMAN;tr|Q5BJH1|Q5BJH1_HUMAN","sp|P07602|SAP_HUMAN;tr|C9JIZ6|C9JIZ6_HUMAN",938,"P07602","SAP_HUMAN","Prosaposin",null,"PSAP"]
["24.0678","23.8843","23.7043","22.8773","23.011","22.4582",{"$nulls":3},"negative regulation of cell proliferation","cadherin binding;RNA binding;zinc ion binding","cell junction;cytosol;focal adhesion;nucleus;plasma membrane;protein complex",{"$nulls":3},18,18,18,"54.2","54.2","54.2","47.996",0,"139.53",2793800000,76,"2.30322",1,"1.1033","5.60537","sp|Q9UGI8|TES_HUMAN;tr|F8W7T0|F8W7T0_HUMAN;tr|H7BYK1|H7BYK1_HUMAN;tr|F8WDI4|F8WDI4_HUMAN","sp|Q9UGI8|TES_HUMAN",5000,"Q9UGI8","TES_HUMAN","Testin",null,"TES"]
["23.2931","22.2694","22.1212","21.3842","21.2772","21.7147",{"$nulls":3},"bone morphogenesis;leukocyte migration;negative regulation of protein processing;negative regulation of transforming growth factor beta receptor signaling pathway;regulation of chondrocyte differentiation","fibroblast growth factor binding;receptor binding","extracellular exosome;Golgi apparatus;Golgi membrane;integral component of membrane;membrane;plasma membrane;proteinaceous extracellular matrix","Cell adhesion molecules (CAMs)",null,null,36,36,36,"39.1","39.1","39.1","134.55",0,"274.15",3895100000,221,"1.31941",1,"1.10249","2.81795","sp|Q92896|GSLG1_HUMAN;tr|H3BM42|H3BM42_HUMAN;tr|H3BQT1|H3BQT1_HUMAN;tr|H3BQU9|H3BQU9_HUMAN;tr|H3BRD8|H3BRD8_HUMAN","sp|Q92896|GSLG1_HUMAN;tr|H3BM42|H3BM42_HUMAN",3733,"Q92896","GSLG1_HUMAN","Golgi apparatus protein 1",null,"GLG1"]
["23.7638","23.309","22.9314","22.5432","21.6279","22.5332",{"$nulls":3},"cristae formation;inner mitochondrial membrane organization;mitochondrial fusion;negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","phosphatase binding;protein complex scaffold activity;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytoplasm;extracellular exosome;MICOS complex;mitochondrial inner membrane;mitochondrion;nucleus",{"$nulls":3},7,7,7,"28.2","28.2","28.2","26.152",0,"56.338",1042400000,41,"1.32922",1,"1.09993","2.8402","sp|Q9NX63|MIC19_HUMAN;tr|C9JRZ6|C9JRZ6_HUMAN;tr|F8WAR4|F8WAR4_HUMAN;tr|F8WD73|F8WD73_HUMAN","sp|Q9NX63|MIC19_HUMAN;tr|C9JRZ6|C9JRZ6_HUMAN;tr|F8WAR4|F8WAR4_HUMAN",4818,"Q9NX63","MIC19_HUMAN","MICOS complex subunit MIC19",null,"CHCHD3"]
["21.6848","20.5081","19.6735","19.4072","19.8223","19.3403",{"$nulls":5},"nuclear body;nucleoplasm",{"$nulls":3},5,5,5,"27.7","27.7","27.7","28.683",0,"41.632",209700000,29,"0.84691",1,"1.0989","1.82371","tr|A0A087WT99|A0A087WT99_HUMAN;sp|Q9H0W9|CK054_HUMAN;tr|E9PPB5|E9PPB5_HUMAN;tr|E9PQS1|E9PQS1_HUMAN;tr|E9PR95|E9PR95_HUMAN;tr|E9PSC3|E9PSC3_HUMAN;tr|E9PLC5|E9PLC5_HUMAN;tr|E9PLB3|E9PLB3_HUMAN;tr|E9PIP1|E9PIP1_HUMAN;tr|E9PJU8|E9PJU8_HUMAN","tr|A0A087WT99|A0A087WT99_HUMAN;sp|Q9H0W9|CK054_HUMAN;tr|E9PPB5|E9PPB5_HUMAN;tr|E9PQS1|E9PQS1_HUMAN;tr|E9PR95|E9PR95_HUMAN;tr|E9PSC3|E9PSC3_HUMAN;tr|E9PLC5|E9PLC5_HUMAN;tr|E9PLB3|E9PLB3_HUMAN;tr|E9PIP1|E9PIP1_HUMAN",4404,"A0A087WT99","A0A087WT99_HUMAN",null,null,"C11orf54"]
["22.1449","21.2729","21.8835","20.7135","20.4733","20.8185",{"$nulls":3},"neutrophil degranulation;proteolysis","dipeptidyl-peptidase activity;serine-type peptidase activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region;Golgi apparatus;intracellular membrane-bounded organelle;vesicle",{"$nulls":3},14,14,14,"47.4","47.4","47.4","54.341",0,"129.27",523470000,37,"1.7759",1,"1.09873","3.9546","sp|Q9UHL4|DPP2_HUMAN;tr|R4GMR2|R4GMR2_HUMAN;tr|R4GNE8|R4GNE8_HUMAN;tr|R4GN05|R4GN05_HUMAN;tr|R4GMU5|R4GMU5_HUMAN;tr|R4GMV4|R4GMV4_HUMAN","sp|Q9UHL4|DPP2_HUMAN",5026,"Q9UHL4","DPP2_HUMAN","Dipeptidyl peptidase 2",null,"DPP7"]
["21.2457","19.1875","19.7588","18.2538","18.088","20.5552",{"$nulls":3},"ADP transport;apoptotic mitochondrial changes;generation of precursor metabolites and energy;mitochondrial genome maintenance;negative regulation of necroptotic process;regulation of insulin secretion;regulation of mitochondrial membrane permeability;transport;viral process","adenine transmembrane transporter activity;ATP:ADP antiporter activity","integral component of mitochondrial membrane;integral component of plasma membrane;mitochondrial inner membrane;mitochondrion;myelin sheath;nucleus","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Necroptosis;Parkinson disease",null,null,15,4,4,"51.7","13.4","13.4","33.064",0,"14.346",488370000,39,"0.47379",1,"1.09836","1.09276","sp|P12235|ADT1_HUMAN;tr|V9GYG0|V9GYG0_HUMAN;sp|Q9H0C2|ADT4_HUMAN","sp|P12235|ADT1_HUMAN;tr|V9GYG0|V9GYG0_HUMAN",1061,"P12235","ADT1_HUMAN","ADP/ATP translocase 1",null,"SLC25A4"]
["20.3585","19.7823","20.5641","19.2319","17.8905","20.2893",{"$nulls":5},"integral component of membrane",{"$nulls":3},8,8,8,"17.8","17.8","17.8","72.54",0,"31.317",198590000,25,"0.681267",1,"1.09773","1.49869","tr|A0A0C4DFM1|A0A0C4DFM1_HUMAN;sp|Q92544|TM9S4_HUMAN;tr|F8WCN2|F8WCN2_HUMAN;tr|F2Z2L1|F2Z2L1_HUMAN","tr|A0A0C4DFM1|A0A0C4DFM1_HUMAN;sp|Q92544|TM9S4_HUMAN",3676,"A0A0C4DFM1","A0A0C4DFM1_HUMAN","Transmembrane 9 superfamily member {ECO:0000256|RuleBase:RU363079}"]
["18.066","20.3878","17.7169","18.4189","16.7491","17.7128",{"$nulls":5},"integral component of membrane",{"$nulls":3},10,10,10,"8.6","8.6","8.6","151.72",0,"39.392",230250000,18,"0.494161",1,"1.09664","1.13304","tr|G3V599|G3V599_HUMAN;sp|O15320|CTGE5_HUMAN;sp|Q96RT6|CTGE2_HUMAN;sp|Q8IX94|CTGE4_HUMAN;sp|Q86UF2|CTGE6_HUMAN;sp|P0CG41|CTGE8_HUMAN;sp|A4D2H0|CTGEF_HUMAN;tr|G3V3C4|G3V3C4_HUMAN;tr|G3V5K6|G3V5K6_HUMAN;sp|Q8IX95|CTGE3_HUMAN;sp|Q96PC5|MIA2_HUMAN;sp|A4FU28|CTGE9_HUMAN","tr|G3V599|G3V599_HUMAN;sp|O15320|CTGE5_HUMAN;sp|Q96RT6|CTGE2_HUMAN",5550,"G3V599","G3V599_HUMAN",null,null,"CTAGE5"]
["23.8077","21.7479","23.3691","22.7421","20.1449","22.7534",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;interferon-gamma-mediated signaling pathway;regulation of immune response;type I interferon signaling pathway;viral process","peptide antigen binding","cell surface;early endosome membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},13,9,3,"42.5","32.6","6.4","40.414",0,"240.48",1301800000,56,"0.438733",1,"1.09474","1.023","sp|P30483|1B45_HUMAN;sp|P30488|1B50_HUMAN;sp|P30487|1B49_HUMAN;sp|P30481|1B44_HUMAN;sp|P30485|1B47_HUMAN","sp|P30483|1B45_HUMAN;sp|P30488|1B50_HUMAN;sp|P30487|1B49_HUMAN;sp|P30481|1B44_HUMAN;sp|P30485|1B47_HUMAN",1384,"P30483","1B45_HUMAN","HLA class I histocompatibility antigen, B-45 alpha chain",null,"HLA-B"]
["22.5925",1,"22.3962","20.3036",1,"21.4036",{"$nulls":3},"intrinsic apoptotic signaling pathway in response to oxidative stress;L-glutamate transport;negative regulation of L-glutamate transport;negative regulation of mitochondrial membrane potential;positive regulation of apoptotic process;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of stress-activated MAPK cascade",null,"cytoskeleton;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;membrane;plasma membrane",{"$nulls":3},4,4,4,"20.2","20.2","20.2","21.614",0,"55.962",167000000,13,"0.0380307",1,"1.09381","0.112085","sp|O75915|PRAF3_HUMAN;tr|F8WF90|F8WF90_HUMAN;tr|C9JQU6|C9JQU6_HUMAN;tr|F8WF33|F8WF33_HUMAN","sp|O75915|PRAF3_HUMAN",649,"O75915","PRAF3_HUMAN","PRA1 family protein 3",null,"ARL6IP5"]
["18.414","17.6846","16.6552","17.9946","15.6489","15.8335",{"$nulls":3},"intra-Golgi vesicle-mediated transport",null,"Golgi apparatus;Golgi membrane;integral component of Golgi membrane;nucleoplasm",{"$nulls":3},14,14,14,"28.5","28.5","28.5","77.454",0,"53.005",273540000,30,"0.52864",1,"1.09231","1.20088","sp|Q13948|CASP_HUMAN;sp|P39880|CUX1_HUMAN","sp|Q13948|CASP_HUMAN;sp|P39880|CUX1_HUMAN",2423,"Q13948","CASP_HUMAN","Protein CASP",null,"CUX1"]
["18.6618","18.6858","19.1678","18.6183","17.9578","16.6668",{"$nulls":3},"phosphatidylinositol biosynthetic process;phosphatidylinositol dephosphorylation","phosphatase activity;phosphatidylinositol bisphosphate phosphatase activity;phosphatidylinositol phosphate 4-phosphatase activity;phosphatidylinositol-3-phosphatase activity;phosphatidylinositol-4-phosphate phosphatase activity","AMPA glutamate receptor complex;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;integral component of endoplasmic reticulum membrane","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,9,9,9,"17.4","17.4","17.4","66.966",0,"26.823",140180000,16,"0.849731",1,"1.09083","1.82931","sp|Q9NTJ5|SAC1_HUMAN;tr|E9PGZ4|E9PGZ4_HUMAN;tr|C9JV50|C9JV50_HUMAN;tr|F8WDN7|F8WDN7_HUMAN;tr|F8WCQ2|F8WCQ2_HUMAN;tr|C9J3E3|C9J3E3_HUMAN","sp|Q9NTJ5|SAC1_HUMAN;tr|E9PGZ4|E9PGZ4_HUMAN",4721,"Q9NTJ5","SAC1_HUMAN","Phosphatidylinositide phosphatase SAC1",null,"SACM1L"]
["20.2921",1,"17.0778","17.1261",1,"16.9761",{"$nulls":3},"acylglycerol acyl-chain remodeling;diacylglycerol metabolic process;fatty acid homeostasis;lipid storage;long-chain fatty-acyl-CoA metabolic process;neutrophil degranulation;triglyceride biosynthetic process;triglyceride metabolic process;very-low-density lipoprotein particle assembly","2-acylglycerol O-acyltransferase activity;diacylglycerol O-acyltransferase activity;retinol O-fatty-acyltransferase activity;transferase activity, transferring acyl groups","endoplasmic reticulum membrane;integral component of membrane;plasma membrane;specific granule membrane","Fat digestion and absorption;Glycerolipid metabolism;Metabolic pathways;Retinol metabolism",null,null,5,5,5,"15.4","15.4","15.4","55.278",0,"23.232",190730000,17,"0.0464983",1,"1.08923","0.135899","sp|O75907|DGAT1_HUMAN;tr|A0A0A0MR74|A0A0A0MR74_HUMAN","sp|O75907|DGAT1_HUMAN;tr|A0A0A0MR74|A0A0A0MR74_HUMAN",647,"O75907","DGAT1_HUMAN","Diacylglycerol O-acyltransferase 1",null,"DGAT1"]
["24.0812","22.691","23.3525","22.8625","21.5389","22.4629",{"$nulls":3},"fatty acid beta-oxidation","isomerase activity;receptor binding","extracellular exosome;membrane;mitochondrion;peroxisome","Peroxisome",null,null,12,12,9,"59.1","59.1","42.7","35.816",0,"323.31",1414600000,81,"0.903724",1,"1.08679","1.93693","sp|Q13011|ECH1_HUMAN;tr|M0R248|M0R248_HUMAN;tr|M0QZW4|M0QZW4_HUMAN;tr|M0R280|M0R280_HUMAN;tr|M0QXS7|M0QXS7_HUMAN","sp|Q13011|ECH1_HUMAN;tr|M0R248|M0R248_HUMAN",2294,"Q13011","ECH1_HUMAN","Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial",null,"ECH1"]
["23.6701","22.1311","23.4743","22.8282","20.3631","22.8295",{"$nulls":3},"branched-chain amino acid catabolic process;valine catabolic process","3-hydroxyisobutyrate dehydrogenase activity;NAD binding;phosphogluconate dehydrogenase (decarboxylating) activity","mitochondrial matrix","Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,9,9,9,"44.9","44.9","44.9","35.329",0,"125.1",946570000,53,"0.496474",1,"1.08489","1.1376","sp|P31937|3HIDH_HUMAN;tr|H7BZL2|H7BZL2_HUMAN","sp|P31937|3HIDH_HUMAN",1411,"P31937","3HIDH_HUMAN","3-hydroxyisobutyrate dehydrogenase, mitochondrial","IBADH","HIBADH"]
["17.424",1,"17.2479","16.4665","14.9542",1,{"$nulls":3},"developmental process;mRNA processing;nucleocytoplasmic transport;regulation of alternative mRNA splicing, via spliceosome;RNA splicing","mRNA binding;RNA binding","intracellular ribonucleoprotein complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},9,9,9,"15.8","15.8","15.8","66.389",0,"34.81",213630000,34,"0.0507171",1,"1.0837","0.147626","sp|Q9H0G5|NSRP1_HUMAN;tr|A0A024QZ33|A0A024QZ33_HUMAN;tr|K7ERM9|K7ERM9_HUMAN;tr|J3KT62|J3KT62_HUMAN;tr|K7EQJ6|K7EQJ6_HUMAN;tr|J3QLV5|J3QLV5_HUMAN;tr|J3QRI6|J3QRI6_HUMAN;tr|K7EMD8|K7EMD8_HUMAN","sp|Q9H0G5|NSRP1_HUMAN;tr|A0A024QZ33|A0A024QZ33_HUMAN",4389,"Q9H0G5","NSRP1_HUMAN","Nuclear speckle splicing regulatory protein 1",null,"NSRP1"]
["24.3132","21.7911","22.2143","22.9894","20.6574","21.4413",{"$nulls":3},"cellular protein modification process;glycoprotein catabolic process;negative regulation of cell proliferation;post-translational protein modification;protein polyubiquitination;protein ubiquitination;proteolysis;regulation of protein ubiquitination;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;ubiquitin-dependent ERAD pathway","amyloid-beta binding;carbohydrate binding;ubiquitin-protein transferase activity","cytoplasm;cytosol;dendritic spine;endoplasmic reticulum;extracellular exosome;organelle membrane;SCF ubiquitin ligase complex","Protein processing in endoplasmic reticulum;Ubiquitin mediated proteolysis",null,null,7,7,7,"32.8","32.8","32.8","33.327",0,"82.075",868460000,30,"0.445933",1,"1.07681","1.03738","sp|Q9UK22|FBX2_HUMAN;tr|R4GNH2|R4GNH2_HUMAN","sp|Q9UK22|FBX2_HUMAN",5075,"Q9UK22","FBX2_HUMAN","F-box only protein 2",null,"FBXO2"]
["17.9602","18.3659","19.4402","16.6059","18.0608","17.8698",{"$nulls":3},"adherens junction maintenance;bundle of His cell-Purkinje myocyte adhesion involved in cell communication;cardiac muscle cell action potential;cardiac muscle cell action potential involved in contraction;cell communication by electrical coupling involved in cardiac conduction;cell-cell adhesion;cell-cell signaling involved in cardiac conduction;cornification;desmosome assembly;gap junction assembly;heart development;intermediate filament bundle assembly;keratinization;lipid homeostasis;maintenance of animal organ identity;negative regulation of cell migration;negative regulation of cell proliferation;positive regulation of sodium ion transport;protein localization to plasma membrane;regulation of bicellular tight junction assembly;regulation of heart rate by cardiac conduction;regulation of ventricular cardiac muscle cell action potential;ventricular cardiac muscle cell action potential;ventricular cardiac muscle tissue morphogenesis","alpha-catenin binding;cadherin binding;cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;intermediate filament binding;ion channel binding;protein complex scaffold activity;protein kinase C binding;sodium channel regulator activity","adherens junction;cell junction;cell-cell junction;cornified envelope;desmosome;integral component of membrane;intercalated disc;intermediate filament;nucleoplasm;nucleus;plasma membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC)",null,null,13,13,13,"19.2","19.2","19.2","97.414",0,"37.303",322120000,27,"0.781785",1,"1.0766","1.69522","sp|Q99959|PKP2_HUMAN;tr|B8QGS9|B8QGS9_HUMAN;tr|A0A087WXY2|A0A087WXY2_HUMAN","sp|Q99959|PKP2_HUMAN;tr|B8QGS9|B8QGS9_HUMAN",4121,"Q99959","PKP2_HUMAN","Plakophilin-2",null,"PKP2"]
["22.7536","21.2978","21.1718","21.2223","20.4026","20.3712",{"$nulls":3},"angiogenesis;cell death;cellular iron ion homeostasis;cellular response to arsenic-containing substance;cellular response to cadmium ion;cellular response to cisplatin;cellular response to heat;cellular response to hypoxia;cellular response to nutrient;endothelial cell proliferation;erythrocyte homeostasis;excretion;heme catabolic process;heme oxidation;intracellular signal transduction;intrinsic apoptotic signaling pathway in response to DNA damage;iron ion homeostasis;liver regeneration;low-density lipoprotein particle clearance;negative regulation of DNA binding;negative regulation of DNA binding transcription factor activity;negative regulation of epithelial cell apoptotic process;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of leukocyte migration;negative regulation of macroautophagy;negative regulation of mast cell cytokine production;negative regulation of mast cell degranulation;negative regulation of muscle cell apoptotic process;negative regulation of neuron apoptotic process;negative regulation of smooth muscle cell proliferation;negative regulation of vascular smooth muscle cell proliferation;positive regulation of angiogenesis;positive regulation of apoptotic process;positive regulation of blood vessel diameter;positive regulation of chemokine biosynthetic process;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of macroautophagy;positive regulation of smooth muscle cell proliferation;protein homooligomerization;regulation of angiogenesis;regulation of blood pressure;regulation of DNA binding transcription factor activity;regulation of transcription from RNA polymerase II promoter in response to iron;regulation of transcription from RNA polymerase II promoter in response to oxidative stress;response to estrogen;response to hydrogen peroxide;response to nicotine;response to oxidative stress;small GTPase mediated signal transduction;smooth muscle hyperplasia;wound healing involved in inflammatory response","enzyme binding;heme binding;heme oxygenase (decyclizing) activity;metal ion binding;phospholipase D activity;protein homodimerization activity;signal transducer activity","caveola;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular space;membrane;nucleolus;nucleus;perinuclear region of cytoplasm","Ferroptosis;Fluid shear stress and atherosclerosis;Hepatocellular carcinoma;HIF-1 signaling pathway;Metabolic pathways;MicroRNAs in cancer;Mineral absorption;Pathways in cancer;Porphyrin and chlorophyll metabolism",null,null,9,9,9,"44.8","44.8","44.8","32.818",0,"79.62",315070000,24,"0.864113",1,"1.0757","1.85787","sp|P09601|HMOX1_HUMAN;tr|B1AHA8|B1AHA8_HUMAN","sp|P09601|HMOX1_HUMAN;tr|B1AHA8|B1AHA8_HUMAN",994,"P09601","HMOX1_HUMAN","Heme oxygenase 1","O-1","HMOX1"]
["19.4533","16.7614","18.9426","17.7404","15.5855","18.6095",{"$nulls":3},"interferon-gamma-mediated signaling pathway;microtubule cytoskeleton organization;negative regulation of microtubule depolymerization;pattern specification process;positive regulation of stress-activated MAPK cascade;protein localization to microtubule","identical protein binding;microtubule binding;phosphoprotein binding;protein heterodimerization activity;protein homodimerization activity;transferase activity;ubiquitin protein ligase binding;zinc ion binding","cytosol;microtubule;microtubule associated complex;spindle","Ubiquitin mediated proteolysis",null,null,5,5,5,"10.2","10.2","10.2","75.25",0,"10.829",79510000,7,"0.367997",1,"1.07396","0.880005","sp|O15344|TRI18_HUMAN;tr|C9J453|C9J453_HUMAN;tr|A0A087X255|A0A087X255_HUMAN;tr|C9JZJ7|C9JZJ7_HUMAN;tr|A0A087X0X0|A0A087X0X0_HUMAN","sp|O15344|TRI18_HUMAN;tr|C9J453|C9J453_HUMAN;tr|A0A087X255|A0A087X255_HUMAN;tr|C9JZJ7|C9JZJ7_HUMAN;tr|A0A087X0X0|A0A087X0X0_HUMAN",364,"O15344","TRI18_HUMAN","E3 ubiquitin-protein ligase Midline-1",null,"MID1"]
["22.1456","21.1066","21.6016","20.7854","20.1003","20.7561",{"$nulls":9},12,12,12,"39.5","39.5","39.5","42.846",0,"117.93",547640000,47,"1.33836",1,"1.07066","2.86104","tr|A0A087WXI1|A0A087WXI1_HUMAN;sp|Q6NVY1|HIBCH_HUMAN;tr|B9A058|B9A058_HUMAN;tr|F8W8A6|F8W8A6_HUMAN;tr|H7C1A5|H7C1A5_HUMAN;tr|B8ZZZ0|B8ZZZ0_HUMAN;tr|H7C126|H7C126_HUMAN;tr|H7BYI7|H7BYI7_HUMAN;tr|H7C400|H7C400_HUMAN","tr|A0A087WXI1|A0A087WXI1_HUMAN;sp|Q6NVY1|HIBCH_HUMAN;tr|B9A058|B9A058_HUMAN",2982,"A0A087WXI1"]
["21.2215","17.3556","18.8475","19.0767","16.7324","18.4172",{"$nulls":3},"apoptotic process;cellular response to DNA damage stimulus;cellular response to dsRNA;defense response to virus;interferon-gamma-mediated signaling pathway;lipopolysaccharide-mediated signaling pathway;macrophage apoptotic process;MDA-5 signaling pathway;negative regulation of type I interferon production;positive regulation of cytokine secretion;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-beta production;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;positive regulation of type I interferon-mediated signaling pathway;programmed necrotic cell death;regulation of type I interferon production;response to exogenous dsRNA;transcription from RNA polymerase II promoter;TRIF-dependent toll-like receptor signaling pathway;type I interferon biosynthetic process;type I interferon signaling pathway;viral process","DNA binding;identical protein binding;protein domain specific binding;protein homodimerization activity;RNA polymerase II proximal promoter sequence-specific DNA binding;sequence-specific DNA binding;transcription cofactor activity;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytoplasm;cytosol;nucleoplasm;nucleus","Cytosolic DNA-sensing pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;NOD-like receptor signaling pathway;Pertussis;RIG-I-like receptor signaling pathway;Toll-like receptor signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,5,5,5,23,23,23,"47.219",0,"17.144",201260000,5,"0.331638",1,"1.06611","0.804944","sp|Q14653|IRF3_HUMAN;tr|M0QYT9|M0QYT9_HUMAN;tr|M0R205|M0R205_HUMAN;tr|M0QZB8|M0QZB8_HUMAN;tr|M0QZB7|M0QZB7_HUMAN;tr|M0R0X9|M0R0X9_HUMAN;tr|M0QXC8|M0QXC8_HUMAN;tr|M0R0R8|M0R0R8_HUMAN;tr|M0R3C2|M0R3C2_HUMAN;tr|M0R007|M0R007_HUMAN;tr|M0QX56|M0QX56_HUMAN;tr|M0R3E9|M0R3E9_HUMAN;tr|M0QYX3|M0QYX3_HUMAN","sp|Q14653|IRF3_HUMAN;tr|M0QYT9|M0QYT9_HUMAN;tr|M0R205|M0R205_HUMAN;tr|M0QZB8|M0QZB8_HUMAN;tr|M0QZB7|M0QZB7_HUMAN;tr|M0R0X9|M0R0X9_HUMAN;tr|M0QXC8|M0QXC8_HUMAN",2485,"Q14653","IRF3_HUMAN","Interferon regulatory factor 3","RF-3","IRF3"]
["19.3331",1,"17.8307",1,"15.9599","18.0091",{"$nulls":5},"centrosome;cytosol;nucleoplasm",{"$nulls":3},4,4,4,"16.1","16.1","16.1","53.305",0,"28.977",54410000,4,"0.0457738",1,"1.06492","0.133876","tr|E5RIH5|E5RIH5_HUMAN;sp|Q6NXR4|TTI2_HUMAN;tr|E5RHM7|E5RHM7_HUMAN","tr|E5RIH5|E5RIH5_HUMAN;sp|Q6NXR4|TTI2_HUMAN",2988,"E5RIH5","E5RIH5_HUMAN",null,null,"TTI2"]
["19.6698","18.6691","17.9919","18.6488","17.8583","16.6308",{"$nulls":3},"actin filament bundle assembly;negative regulation of actin filament depolymerization;ruffle organization","actin filament binding;actin monomer binding;cadherin binding;metal ion binding","actin cytoskeleton;brush border;cleavage furrow;cytoplasm;focal adhesion;stress fiber",{"$nulls":3},9,9,9,"17.4","17.4","17.4","85.225",0,"21.029",242290000,30,"0.627951",1,"1.06427","1.39485","sp|Q9UHB6|LIMA1_HUMAN;tr|F8VQE1|F8VQE1_HUMAN;tr|F8VRN8|F8VRN8_HUMAN;tr|F8VS07|F8VS07_HUMAN;tr|F8VTU2|F8VTU2_HUMAN","sp|Q9UHB6|LIMA1_HUMAN;tr|F8VQE1|F8VQE1_HUMAN;tr|F8VRN8|F8VRN8_HUMAN;tr|F8VS07|F8VS07_HUMAN",5016,"Q9UHB6","LIMA1_HUMAN","LIM domain and actin-binding protein 1",null,"LIMA1"]
["19.1602","18.837","18.5126","16.1929","18.8211","18.3068",{"$nulls":3},"immune response;negative regulation of cell cycle G1/S phase transition;negative regulation of cell division","polysaccharide binding;scavenger receptor activity","extracellular exosome;integral component of membrane;plasma membrane",{"$nulls":3},7,7,7,"12.8","12.8","12.8","90.207",0,"38.7",218640000,31,"0.572884",1,"1.06299","1.28747","sp|Q9UGT4|SUSD2_HUMAN","sp|Q9UGT4|SUSD2_HUMAN",5006,"Q9UGT4","SUSD2_HUMAN","Sushi domain-containing protein 2",null,"SUSD2"]
["17.7635","15.8808","16.0775","16.866","14.4525","15.2156",{"$nulls":4},"kinase activity",{"$nulls":4},5,5,5,"13.4","13.4","13.4","73.314",0,"8.7161",40136000,12,"0.499182",1,"1.06257","1.14294","tr|B4DKV7|B4DKV7_HUMAN;sp|Q8TE68|ES8L1_HUMAN;tr|K7EN83|K7EN83_HUMAN;tr|K7EKX9|K7EKX9_HUMAN;tr|K7ELW3|K7ELW3_HUMAN","tr|B4DKV7|B4DKV7_HUMAN;sp|Q8TE68|ES8L1_HUMAN;tr|K7EN83|K7EN83_HUMAN;tr|K7EKX9|K7EKX9_HUMAN",3571,"B4DKV7","B4DKV7_HUMAN",null,null,"EPS8L1"]
["20.9806","19.8119","20.242","19.3874","18.7676","19.6952",{"$nulls":3},"cellular response to glucose stimulus;cellular response to tumor necrosis factor;gluconeogenesis;NADH oxidation;oxaloacetate metabolic process;positive regulation of insulin secretion;pyruvate metabolic process;response to dexamethasone;response to lipopolysaccharide","GTP binding;metal ion binding;phosphoenolpyruvate carboxykinase (GTP) activity;phosphoenolpyruvate carboxykinase activity","extracellular exosome;mitochondrial matrix;mitochondrion","Adipocytokine signaling pathway;AMPK signaling pathway;Citrate cycle (TCA cycle);FoxO signaling pathway;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;Insulin resistance;Insulin signaling pathway;Metabolic pathways;PI3K-Akt signaling pathway;PPAR signaling pathway;Proximal tubule bicarbonate reclamation;Pyruvate metabolism",null,null,17,17,17,"33.1","33.1","33.1","70.729",0,"76.869",570690000,51,"1.1426",1,"1.06148","2.42962","sp|Q16822|PCKGM_HUMAN;tr|B4DW73|B4DW73_HUMAN;tr|H0YML5|H0YML5_HUMAN;tr|H0YM31|H0YM31_HUMAN;tr|A0A0A0MS74|A0A0A0MS74_HUMAN;tr|H0YNG4|H0YNG4_HUMAN;tr|H0YMA5|H0YMA5_HUMAN;tr|H0YMU6|H0YMU6_HUMAN;sp|P35558|PCKGC_HUMAN","sp|Q16822|PCKGM_HUMAN;tr|B4DW73|B4DW73_HUMAN;tr|H0YML5|H0YML5_HUMAN;tr|H0YM31|H0YM31_HUMAN;tr|A0A0A0MS74|A0A0A0MS74_HUMAN",2698,"Q16822","PCKGM_HUMAN","Phosphoenolpyruvate carboxykinase [GTP], mitochondrial","EPCK-M","PCK2"]
["25.7223","25.2533","24.4232","24.7357","23.5713","23.9102",{"$nulls":3},"actin filament bundle assembly;bicellular tight junction assembly;negative regulation of cellular component movement;negative regulation of substrate adhesion-dependent cell spreading;peroxisome proliferator activated receptor signaling pathway;platelet degranulation;positive regulation of cell migration;positive regulation of cellular component movement;positive regulation of NIK/NF-kappaB signaling;positive regulation of pinocytosis;positive regulation of sodium:proton antiporter activity;protein localization to bicellular tight junction;protein transport;regulation of apoptotic process;regulation of nucleic acid-templated transcription;response to hypoxia;retinoic acid receptor signaling pathway;vesicle transport along actin filament","actin binding;actin filament binding;calcium ion binding;chromatin DNA binding;integrin binding;ion channel binding;ligand-dependent nuclear receptor transcription coactivator activity;nuclear hormone receptor binding;nucleoside binding;protein homodimerization activity;protein N-terminus binding;retinoic acid receptor binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding","brush border;cell-cell junction;cortical cytoskeleton;cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;focal adhesion;intracellular;intracellular ribonucleoprotein complex;neuron projection;nuclear body;nucleus;perinuclear region of cytoplasm;platelet alpha granule lumen;protein complex;pseudopodium;stress fiber;Z disc","Adherens junction;Amoebiasis;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Systemic lupus erythematosus;Tight junction;Viral carcinogenesis",null,null,60,60,42,"71.5","71.5","50.9","104.85",0,"323.31",17951000000,629,"0.967055",1,"1.06051","2.06466","sp|O43707|ACTN4_HUMAN;tr|F5GXS2|F5GXS2_HUMAN;tr|H7C144|H7C144_HUMAN;tr|K7EJH8|K7EJH8_HUMAN;tr|K7EP19|K7EP19_HUMAN","sp|O43707|ACTN4_HUMAN;tr|F5GXS2|F5GXS2_HUMAN",446,"O43707","ACTN4_HUMAN","Alpha-actinin-4 {ECO:0000305}",null,"ACTN4"]
["20.9032","19.3069","19.7556","18.6314","18.7487","19.4052",{"$nulls":3},"branched-chain amino acid catabolic process;cellular nitrogen compound metabolic process","dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity;ubiquitin protein ligase binding","mitochondrial alpha-ketoglutarate dehydrogenase complex;mitochondrial matrix;mitochondrial nucleoid;mitochondrion","Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,19,19,19,"54.1","54.1","54.1","53.486",0,"198.53",942820000,63,"0.930027",1,"1.06013","1.98976","sp|P11182|ODB2_HUMAN;tr|Q5VVL7|Q5VVL7_HUMAN","sp|P11182|ODB2_HUMAN;tr|Q5VVL7|Q5VVL7_HUMAN",1040,"P11182","ODB2_HUMAN","Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial",null,"DBT"]
["20.5516","18.6975","20.0564","18.4745","18.1045","19.551",{"$nulls":3},"Golgi organization;negative regulation of neuron projection development;negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of protein refolding;negative regulation of protein ubiquitination;negative regulation of ubiquitin-protein transferase activity;neuron death;protein folding;regulation of cellular response to heat;regulation of inclusion body assembly;regulation of ubiquitin-protein transferase activity","adenyl-nucleotide exchange factor activity;chaperone binding;protein kinase binding;ubiquitin protein ligase binding","cytosol;inclusion body;membrane;mitochondrion;nucleus;perinuclear region of cytoplasm",{"$nulls":3},7,7,7,"24.6","24.6","24.6","51.199",0,"69.13",195900000,21,"0.683897",1,"1.05848","1.50382","sp|Q9UL15|BAG5_HUMAN;tr|G3V274|G3V274_HUMAN","sp|Q9UL15|BAG5_HUMAN",5106,"Q9UL15","BAG5_HUMAN","BAG family molecular chaperone regulator 5","AG-5","BAG5"]
["23.3802","22.5594","23.7677","21.6466","21.7313","23.1582",{"$nulls":5},"mitochondrion",{"$nulls":3},11,10,10,"57.3","52.7","52.7","30.376",0,"223.8",1222700000,58,"0.806643",1,"1.05707","1.74413","tr|A0A096LPI6|A0A096LPI6_HUMAN;tr|A0A0B4J2D5|A0A0B4J2D5_HUMAN;sp|P30042|ES1_HUMAN;tr|A0A096LNH5|A0A096LNH5_HUMAN;tr|H7C1F6|H7C1F6_HUMAN;tr|A0A0B4J2H4|A0A0B4J2H4_HUMAN;tr|H7C2G3|H7C2G3_HUMAN;tr|A0A096LP73|A0A096LP73_HUMAN;tr|F2Z2Q0|F2Z2Q0_HUMAN;tr|A0A096LP12|A0A096LP12_HUMAN;tr|A0A096LNJ1|A0A096LNJ1_HUMAN","tr|A0A096LPI6|A0A096LPI6_HUMAN;tr|A0A0B4J2D5|A0A0B4J2D5_HUMAN;sp|P30042|ES1_HUMAN;tr|A0A096LNH5|A0A096LNH5_HUMAN;tr|H7C1F6|H7C1F6_HUMAN;tr|A0A0B4J2H4|A0A0B4J2H4_HUMAN;tr|H7C2G3|H7C2G3_HUMAN",5444,"A0A096LPI6","A0A096LPI6_HUMAN"]
["21.0221","17.9365","18.9771","19.9549","16.3414","18.4696",{"$nulls":5},"integral component of membrane",{"$nulls":3},5,5,5,"16.4","16.4","16.4","40.99",0,"16.257",95082000,20,"0.31128",1,"1.05659","0.762331","tr|E9PHY0|E9PHY0_HUMAN;sp|P11117|PPAL_HUMAN;tr|E9PP23|E9PP23_HUMAN;tr|E9PQY3|E9PQY3_HUMAN;tr|B7Z7D2|B7Z7D2_HUMAN;tr|E9PKW9|E9PKW9_HUMAN;tr|E9PQW9|E9PQW9_HUMAN;tr|B7Z6U3|B7Z6U3_HUMAN","tr|E9PHY0|E9PHY0_HUMAN;sp|P11117|PPAL_HUMAN;tr|E9PP23|E9PP23_HUMAN;tr|E9PQY3|E9PQY3_HUMAN;tr|B7Z7D2|B7Z7D2_HUMAN",1033,"E9PHY0","E9PHY0_HUMAN",null,null,"ACP2"]
["21.2982","20.4911","19.6059","20.0344","18.9128","19.2828",{"$nulls":3},"cell adhesion;cell migration;epithelial tube formation;glomerular visceral epithelial cell development;negative regulation of cell adhesion;negative regulation of cell-cell adhesion;positive regulation of cell migration;positive regulation of cell-cell adhesion mediated by integrin;regulation of microvillus assembly",null,"apical plasma membrane;cytoplasm;extracellular exosome;extracellular space;filopodium;integral component of plasma membrane;intracellular membrane-bounded organelle;lamellipodium;membrane raft;microtubule organizing center;microvillus membrane;nucleolus;plasma membrane;ruffle;slit diaphragm",{"$nulls":3},4,4,4,"8.1","8.1","8.1","58.635",0,"18.316",278990000,18,"0.829534",1,"1.0551","1.78931","sp|O00592|PODXL_HUMAN","sp|O00592|PODXL_HUMAN",258,"O00592","PODXL_HUMAN","Podocalyxin",null,"PODXL"]
["20.9778","19.0879","19.2561","18.3996","18.8283","18.9348",{"$nulls":4},"metal ion binding","cytosol;plasma membrane",{"$nulls":3},3,3,3,"22.3","22.3","22.3","20.885",0,"19.639",96150000,12,"0.775656",1,"1.05309","1.68319","tr|A0A096LNV3|A0A096LNV3_HUMAN;tr|A0A096LP02|A0A096LP02_HUMAN;sp|Q9Y508|RN114_HUMAN;tr|A0A096LNT1|A0A096LNT1_HUMAN;tr|A0A096LNN8|A0A096LNN8_HUMAN;tr|A0A096LPF9|A0A096LPF9_HUMAN","tr|A0A096LNV3|A0A096LNV3_HUMAN;tr|A0A096LP02|A0A096LP02_HUMAN;sp|Q9Y508|RN114_HUMAN;tr|A0A096LNT1|A0A096LNT1_HUMAN;tr|A0A096LNN8|A0A096LNN8_HUMAN;tr|A0A096LPF9|A0A096LPF9_HUMAN",5339,"A0A096LNV3","A0A096LNV3_HUMAN",null,null,"RNF114"]
["23.6162","22.1303","21.838","22.2122","21.6865","20.5325",{"$nulls":3},"epithelial cell differentiation;glutathione derivative biosynthetic process;glutathione metabolic process","glutathione peroxidase activity;glutathione transferase activity;protein disulfide oxidoreductase activity;receptor binding","extracellular exosome;intracellular;membrane;mitochondrial inner membrane;mitochondrial matrix;peroxisome","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Glutathione metabolism;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Peroxisome",null,null,8,8,8,"50.4","50.4","50.4","25.497",0,"58.477",730510000,36,"0.640012",1,"1.05106","1.41834","sp|Q9Y2Q3|GSTK1_HUMAN;tr|E9PFN5|E9PFN5_HUMAN;tr|C9JNT3|C9JNT3_HUMAN","sp|Q9Y2Q3|GSTK1_HUMAN;tr|E9PFN5|E9PFN5_HUMAN",5232,"Q9Y2Q3","GSTK1_HUMAN","Glutathione S-transferase kappa 1",null,"GSTK1"]
["21.0115","18.9403","19.4352","19.893","17.8301","18.5203",{"$nulls":3},"ammonia assimilation cycle;cell proliferation;cellular amino acid biosynthetic process;cellular response to starvation;glutamate catabolic process;glutamine biosynthetic process;neurotransmitter uptake;positive regulation of epithelial cell proliferation;positive regulation of insulin secretion;positive regulation of synaptic transmission, glutamatergic;protein homooligomerization;response to glucose","ATP binding;dynein light chain binding;glutamate binding;glutamate decarboxylase activity;glutamate-ammonia ligase activity;identical protein binding;magnesium ion binding;manganese ion binding","axon terminus;cytosol;extracellular exosome;glial cell projection;mitochondrion;myelin sheath;nucleus;perikaryon;protein complex;rough endoplasmic reticulum","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;GABAergic synapse;Glutamatergic synapse;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Necroptosis;Nitrogen metabolism",null,null,7,7,7,"19.6","19.6","19.6","42.064",0,"26.594",198190000,19,"0.530183",1,"1.04787","1.2039","sp|P15104|GLNA_HUMAN;tr|A0A087WYJ1|A0A087WYJ1_HUMAN","sp|P15104|GLNA_HUMAN",1113,"P15104","GLNA_HUMAN","Glutamine synthetase","S","GLUL"]
["19.6813","19.6414","16.9037","19.3676","16.376","17.344",{"$nulls":3},"glycosaminoglycan biosynthetic process","heparan sulfate 2-O-sulfotransferase activity","Golgi membrane;integral component of membrane;membrane","Glycosaminoglycan biosynthesis - heparan sulfate / heparin",null,null,10,10,10,"39.3","39.3","39.3","41.881",0,"59.4",853020000,75,"0.33962",1,"1.04623","0.821531","sp|Q7LGA3|HS2ST_HUMAN;tr|K7EP71|K7EP71_HUMAN","sp|Q7LGA3|HS2ST_HUMAN",3138,"Q7LGA3","HS2ST_HUMAN","Heparan sulfate 2-O-sulfotransferase 1","OST;-O-sulfotransferase","HS2ST1"]
["21.2714","19.2346","19.3527","19.233","19.064","18.426",{"$nulls":9},4,4,4,"22.7","22.7","22.7","33.422",0,"22.536",101490000,6,"0.673661",1,"1.04525","1.48388","tr|G3V4S9|G3V4S9_HUMAN;sp|Q9UN36|NDRG2_HUMAN;tr|G3V5L7|G3V5L7_HUMAN;tr|G3V5H8|G3V5H8_HUMAN;tr|G3V578|G3V578_HUMAN;tr|H0YJT9|H0YJT9_HUMAN;tr|A0A0A0MS87|A0A0A0MS87_HUMAN;tr|G3V2A6|G3V2A6_HUMAN;tr|G3V5S0|G3V5S0_HUMAN;tr|G3V392|G3V392_HUMAN;tr|G3V5G0|G3V5G0_HUMAN;tr|G3V2I9|G3V2I9_HUMAN;tr|G3V4X3|G3V4X3_HUMAN;tr|G3V5B5|G3V5B5_HUMAN;tr|G3V239|G3V239_HUMAN;tr|G3V5P9|G3V5P9_HUMAN;tr|G3V5D7|G3V5D7_HUMAN;tr|G3V420|G3V420_HUMAN;tr|G3V2S0|G3V2S0_HUMAN;tr|G3V3C3|G3V3C3_HUMAN;tr|G3V2Y3|G3V2Y3_HUMAN;tr|G3V5G7|G3V5G7_HUMAN;tr|G3V552|G3V552_HUMAN;tr|G3V3X3|G3V3X3_HUMAN;tr|G3V3P6|G3V3P6_HUMAN;tr|G3V237|G3V237_HUMAN;tr|G3V4T9|G3V4T9_HUMAN;tr|G3V2T2|G3V2T2_HUMAN;tr|G3V5A6|G3V5A6_HUMAN;tr|G3V280|G3V280_HUMAN;tr|G3V3P1|G3V3P1_HUMAN;tr|G3V5V9|G3V5V9_HUMAN;tr|G3V3D5|G3V3D5_HUMAN;tr|G3V3X2|G3V3X2_HUMAN;tr|G3V285|G3V285_HUMAN;tr|G3V4S2|G3V4S2_HUMAN;tr|G3V271|G3V271_HUMAN;tr|G3V358|G3V358_HUMAN;tr|G3V5B7|G3V5B7_HUMAN;tr|G3V383|G3V383_HUMAN","tr|G3V4S9|G3V4S9_HUMAN;sp|Q9UN36|NDRG2_HUMAN;tr|G3V5L7|G3V5L7_HUMAN;tr|G3V5H8|G3V5H8_HUMAN;tr|G3V578|G3V578_HUMAN;tr|H0YJT9|H0YJT9_HUMAN;tr|A0A0A0MS87|A0A0A0MS87_HUMAN;tr|G3V2A6|G3V2A6_HUMAN;tr|G3V5S0|G3V5S0_HUMAN;tr|G3V392|G3V392_HUMAN;tr|G3V5G0|G3V5G0_HUMAN;tr|G3V2I9|G3V2I9_HUMAN",5146,"G3V4S9","G3V4S9_HUMAN",null,null,"NDRG2"]
["27.0837","26.683","26.4111","25.8414","25.1168","26.0899",{"$nulls":3},"histone H3-K27 trimethylation;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;nucleosome assembly;nucleosome positioning","chromatin DNA binding;RNA binding","nuclear euchromatin;nucleosome;nucleus;transcriptionally active chromatin",{"$nulls":3},9,9,3,"33.3","33.3","13.6","21.364",0,"52.055",41162000000,306,"1.38574",1,"1.04318","2.97012","sp|P16403|H12_HUMAN","sp|P16403|H12_HUMAN",1135,"P16403","H12_HUMAN","Histone H1.2",null,"HIST1H1C"]
["17.587",1,"17.4277","16.2174","15.6752",1,{"$nulls":3},"angiogenesis;cardiac epithelial to mesenchymal transition;cell-matrix adhesion;collagen catabolic process;extracellular matrix disassembly;extracellular matrix organization;immune response to tumor cell;innate immune response;integrin-mediated signaling pathway;male gonad development;negative regulation of cell growth;negative regulation of cell migration;negative regulation of cell-matrix adhesion;negative regulation of receptor binding;protein kinase C signaling;tissue regeneration","integrin binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;SH3 domain binding","acrosomal vesicle;adherens junction;cell projection;cell surface;extracellular exosome;integral component of membrane;plasma membrane",{"$nulls":3},2,2,2,"3.1","3.1","3.1","92.958",0,"24.96",47205000,10,"0.0480307",1,"1.0407","0.140169","sp|Q13444|ADA15_HUMAN","sp|Q13444|ADA15_HUMAN",2361,"Q13444","ADA15_HUMAN","Disintegrin and metalloproteinase domain-containing protein 15","DAM 15","ADAM15"]
["25.2146","23.7801","23.5681","23.7497","22.7532","22.9474",{"$nulls":3},"cell proliferation;cellular response to antibiotic;cellular response to UV-B;heart development;immune response;intrinsic apoptotic signaling pathway in response to DNA damage;prostate gland stromal morphogenesis;regulation of gene expression;response to organic substance;response to zinc ion","AT DNA binding;DNA binding, bending;peptide binding;zinc ion binding","cytoplasm",{"$nulls":3},2,2,2,"28.6","28.6","28.6","8.5328",0,"13.11",419660000,7,"0.798504",1,"1.03753","1.7281","sp|P50238|CRIP1_HUMAN;tr|K4DIB9|K4DIB9_HUMAN;tr|H3BRQ4|H3BRQ4_HUMAN","sp|P50238|CRIP1_HUMAN;tr|K4DIB9|K4DIB9_HUMAN;tr|H3BRQ4|H3BRQ4_HUMAN",1701,"P50238","CRIP1_HUMAN","Cysteine-rich protein 1","RP-1","CRIP1"]
[1,"14.9126","17.1037","16.4397","12.4796",1,{"$nulls":3},"chromatin remodeling","DNA binding","cytosol;nucleoplasm;plasma membrane;SWI/SNF superfamily-type complex",{"$nulls":3},11,9,9,"9.7","7.5","7.5","190.69",0,"57.991",202030000,29,"0.0518643",1,"1.03232","0.150799","tr|H0Y7H8|H0Y7H8_HUMAN;sp|Q8NFD5|ARI1B_HUMAN;tr|H0Y2R3|H0Y2R3_HUMAN;tr|H0Y3S9|H0Y3S9_HUMAN;tr|A0A0J9YY80|A0A0J9YY80_HUMAN","tr|H0Y7H8|H0Y7H8_HUMAN;sp|Q8NFD5|ARI1B_HUMAN",3503,"H0Y7H8","H0Y7H8_HUMAN",null,null,"ARID1B"]
["17.9593","14.8727","15.1545","16.1863","13.1503","15.5575",{"$nulls":3},"lactate metabolic process;mitochondrial magnesium ion transmembrane transport;transmembrane transport","magnesium ion transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},2,2,2,"8.8","8.8","8.8","50.317",0,"7.4284",15248000,6,"0.311461",1,"1.03085","0.762712","sp|Q9HD23|MRS2_HUMAN;tr|H7BZ29|H7BZ29_HUMAN;tr|A0A0A0MQX2|A0A0A0MQX2_HUMAN","sp|Q9HD23|MRS2_HUMAN;tr|H7BZ29|H7BZ29_HUMAN;tr|A0A0A0MQX2|A0A0A0MQX2_HUMAN",4607,"Q9HD23","MRS2_HUMAN","Magnesium transporter MRS2 homolog, mitochondrial",null,"MRS2"]
["28.0425","26.761","26.3443","26.6391","25.3331","26.0893",{"$nulls":3},"cellular response to interleukin-6;DNA biosynthetic process;histone deacetylation;mitochondrial calcium ion transmembrane transport;mitochondrion organization;negative regulation of androgen receptor signaling pathway;negative regulation of cell growth;negative regulation of cell proliferation;negative regulation of ERK1 and ERK2 cascade;negative regulation of glucocorticoid receptor signaling pathway;negative regulation of protein catabolic process;negative regulation of transcription by competitive promoter binding;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;osteoblast differentiation;positive regulation of cell death;positive regulation of complement activation;positive regulation of ERK1 and ERK2 cascade;positive regulation of gene expression;positive regulation of G-protein coupled receptor protein signaling pathway;positive regulation of transcription, DNA-templated;progesterone receptor signaling pathway;protein stabilization;regulation of apoptotic process;regulation of transcription, DNA-templated;signal transduction","complement component C3a binding;complement component C3b binding;enzyme binding;histone deacetylase binding;protein C-terminus binding;proteinase activated receptor binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcription regulatory region DNA binding","cell surface;cytoplasm;early endosome;extracellular exosome;integral component of plasma membrane;membrane;mitochondrial inner membrane;mitochondrion;myelin sheath;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},21,21,21,"84.9","84.9","84.9","29.804",0,"323.31",16791000000,266,"0.742248",1,"1.0288","1.61773","sp|P35232|PHB_HUMAN;tr|C9JW96|C9JW96_HUMAN;tr|C9JZ20|C9JZ20_HUMAN;tr|E7ESE2|E7ESE2_HUMAN;tr|E9PCW0|E9PCW0_HUMAN;tr|D6RBK0|D6RBK0_HUMAN","sp|P35232|PHB_HUMAN;tr|C9JW96|C9JW96_HUMAN;tr|C9JZ20|C9JZ20_HUMAN;tr|E7ESE2|E7ESE2_HUMAN;tr|E9PCW0|E9PCW0_HUMAN",1449,"P35232","PHB_HUMAN","Prohibitin",null,"PHB"]
["19.7627","19.168","18.4527","17.929","19.122","17.2478",{"$nulls":3},"cellular amino acid biosynthetic process;L-proline biosynthetic process","pyrroline-5-carboxylate reductase activity","cytosol","Arginine and proline metabolism;Biosynthesis of amino acids;Metabolic pathways",null,null,6,6,6,"29.2","29.2","29.2","28.663",0,"22.13",64696000,6,"0.704542",1,"1.0282","1.54407","sp|Q53H96|P5CR3_HUMAN;tr|A0A0A0MQS1|A0A0A0MQS1_HUMAN;tr|B5MD87|B5MD87_HUMAN;tr|F8WEI0|F8WEI0_HUMAN","sp|Q53H96|P5CR3_HUMAN;tr|A0A0A0MQS1|A0A0A0MQS1_HUMAN;tr|B5MD87|B5MD87_HUMAN",2783,"Q53H96","P5CR3_HUMAN","Pyrroline-5-carboxylate reductase 3 {ECO:0000312|HGNC:HGNC:25846}","5C reductase 3;5CR 3","PYCR3"]
["19.851","20.3924","20.2918","19.2875","18.8664","19.2974",{"$nulls":3},"maturation of LSU-rRNA;positive regulation of cell proliferation;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;ribosomal large subunit assembly;rRNA base methylation","RNA binding;rRNA (cytosine-C5-)-methyltransferase activity","nucleolus;nucleoplasm",{"$nulls":3},14,14,14,"20.1","20.1","20.1","89.301",0,"57.276",490310000,56,"2.03147",1,"1.02798","4.70106","sp|P46087|NOP2_HUMAN;tr|A0A087WV73|A0A087WV73_HUMAN;tr|F5GWB7|F5GWB7_HUMAN;tr|F5H709|F5H709_HUMAN;tr|F5H5X6|F5H5X6_HUMAN;tr|F5H359|F5H359_HUMAN;tr|F5GYR3|F5GYR3_HUMAN;tr|F5H8G6|F5H8G6_HUMAN","sp|P46087|NOP2_HUMAN;tr|A0A087WV73|A0A087WV73_HUMAN",1586,"P46087","NOP2_HUMAN","Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase",null,"NOP2"]
["24.6501","23.5683","23.0733","22.9234","22.8116","22.4816",{"$nulls":3},"cotranslational protein targeting to membrane;IRE1-mediated unfolded protein response;positive regulation of cell proliferation",null,"endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Protein processing in endoplasmic reticulum",null,null,5,5,5,29,29,29,"32.235",0,"100.79",1631200000,82,"0.992967",1,"1.02503","2.11746","sp|P43307|SSRA_HUMAN;tr|C9J3L8|C9J3L8_HUMAN;tr|C9J5W0|C9J5W0_HUMAN;tr|E9PAL7|E9PAL7_HUMAN;tr|C9IZQ1|C9IZQ1_HUMAN;tr|C9JBX5|C9JBX5_HUMAN","sp|P43307|SSRA_HUMAN;tr|C9J3L8|C9J3L8_HUMAN;tr|C9J5W0|C9J5W0_HUMAN;tr|E9PAL7|E9PAL7_HUMAN;tr|C9IZQ1|C9IZQ1_HUMAN",1571,"P43307","SSRA_HUMAN","Translocon-associated protein subunit alpha","RAP-alpha","SSR1"]
["24.9992","24.0315","24.198","23.4837","23.3037","23.3855",{"$nulls":3},"autophagic cell death;establishment of protein localization to organelle;Golgi to lysosome transport;granzyme-mediated apoptotic signaling pathway;neutrophil degranulation;positive regulation of natural killer cell degranulation;positive regulation of natural killer cell mediated cytotoxicity;protein stabilization;regulation of organelle transport along microtubule","enzyme binding;protein domain specific binding;virus receptor activity","alveolar lamellar body;autolysosome;azurophil granule membrane;cytolytic granule;cytoplasm;cytosol;dendrite;endosome membrane;external side of plasma membrane;extracellular exosome;ficolin-1-rich granule membrane;integral component of plasma membrane;late endosome;lysosomal membrane;lysosome;melanosome;membrane;multivesicular body;neuronal cell body;perinuclear region of cytoplasm;phagolysosome membrane;plasma membrane;sarcolemma;synaptic vesicle","Autophagy - animal;Lysosome;Phagosome;Tuberculosis",null,null,8,8,8,"16.5","16.5","16.5","44.882",0,"159.99",3027000000,39,"1.54794",1,"1.01862","3.35951","sp|P11279|LAMP1_HUMAN","sp|P11279|LAMP1_HUMAN",1044,"P11279","LAMP1_HUMAN","Lysosome-associated membrane glycoprotein 1","AMP-1;ysosome-associated membrane protein 1","LAMP1"]
["19.9083","18.9106","18.8282","19.2021","16.9579","18.4394",{"$nulls":3},"cellular calcium ion homeostasis;mRNA splicing, via spliceosome;negative regulation of cell proliferation;nervous system development;positive regulation of NFAT protein import into nucleus;release of sequestered calcium ion into cytosol","ion channel binding;RNA binding","cytoplasm;membrane;nucleoplasm;perinuclear region of cytoplasm;sarcoplasmic reticulum membrane","Spliceosome",null,null,13,13,13,"20.5","20.5","20.5","103.7",0,"38.75",326440000,41,"0.612262",1,"1.01595","1.36428","sp|Q8IWX8|CHERP_HUMAN;tr|J3QK89|J3QK89_HUMAN","sp|Q8IWX8|CHERP_HUMAN;tr|J3QK89|J3QK89_HUMAN",3312,"Q8IWX8","CHERP_HUMAN","Calcium homeostasis endoplasmic reticulum protein",null,"CHERP"]
["22.4499","21.4565","21.2988","21.1188","20.3334","20.7072",{"$nulls":4},"RNA binding","intracellular ribonucleoprotein complex;nucleoplasm;viral nucleocapsid",{"$nulls":3},6,5,5,"21.2",19,19,"40.04",0,"28.339",624730000,26,"1.12142",1,"1.01527","2.38461","tr|A0A087WUK2|A0A087WUK2_HUMAN;sp|O14979|HNRDL_HUMAN","tr|A0A087WUK2|A0A087WUK2_HUMAN;sp|O14979|HNRDL_HUMAN",320,"A0A087WUK2","A0A087WUK2_HUMAN",null,null,"HNRNPDL"]
["20.4566","17.8103","19.5858","18.9203","17.0384","18.865",{"$nulls":3},"chromatin maintenance;DNA duplex unwinding;DNA recombination;mitochondrial mRNA catabolic process;mitochondrial mRNA surveillance;mitochondrial ncRNA surveillance;mitochondrial RNA 3'-end processing;mitochondrial RNA surveillance;mitochondrion morphogenesis;negative regulation of apoptotic process;positive regulation of cell growth;positive regulation of mitochondrial RNA catabolic process;RNA catabolic process","3'-5' RNA helicase activity;ATP binding;ATP-dependent RNA helicase activity;DNA binding;DNA helicase activity;double-stranded RNA binding;helicase activity;protein homodimerization activity;RNA binding","mitochondrial degradosome;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleus",{"$nulls":3},15,15,15,"22.5","22.5","22.5","87.99",0,"45.39",227730000,28,"0.434985",1,"1.00969","1.01551","sp|Q8IYB8|SUV3_HUMAN;tr|B1AR60|B1AR60_HUMAN","sp|Q8IYB8|SUV3_HUMAN",3338,"Q8IYB8","SUV3_HUMAN","ATP-dependent RNA helicase SUPV3L1, mitochondrial",null,"SUPV3L1"]
["24.2086","22.9243","23.8965","22.9915","21.8417","23.1689",{"$nulls":3},"aerobic respiration;aging;cellular response to growth factor stimulus;cellular response to oxidative stress;cholesterol metabolic process;hemoglobin metabolic process;hydrogen peroxide catabolic process;negative regulation of apoptotic process;negative regulation of NF-kappaB transcription factor activity;neutrophil degranulation;osteoblast differentiation;positive regulation of cell division;positive regulation of NF-kappaB transcription factor activity;positive regulation of phosphatidylinositol 3-kinase signaling;protein homotetramerization;protein tetramerization;response to activity;response to cadmium ion;response to drug;response to estradiol;response to ethanol;response to fatty acid;response to hydrogen peroxide;response to hyperoxia;response to hypoxia;response to inactivity;response to insulin;response to L-ascorbic acid;response to lead ion;response to light intensity;response to ozone;response to phenylpropanoid;response to reactive oxygen species;response to vitamin A;response to vitamin E;triglyceride metabolic process;ureteric bud development;UV protection","aminoacylase activity;antioxidant activity;catalase activity;enzyme binding;heme binding;metal ion binding;NADP binding;oxidoreductase activity, acting on peroxide as acceptor;protein homodimerization activity;receptor binding","cytosol;endoplasmic reticulum;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;Golgi apparatus;intracellular membrane-bounded organelle;lysosome;membrane;mitochondrial intermembrane space;mitochondrion;peroxisomal matrix;peroxisomal membrane;peroxisome;plasma membrane;secretory granule lumen","Amyotrophic lateral sclerosis (ALS);Carbon metabolism;FoxO signaling pathway;Glyoxylate and dicarboxylate metabolism;Longevity regulating pathway;Longevity regulating pathway - multiple species;Metabolic pathways;Peroxisome;Tryptophan metabolism",null,null,28,28,28,"56.5","56.5","56.5","59.755",0,"295.92",2892400000,131,"0.823129",1,"1.00912","1.77665","sp|P04040|CATA_HUMAN","sp|P04040|CATA_HUMAN",860,"P04040","CATA_HUMAN","Catalase",null,"CAT"]
["22.5282","20.7705","21.2079","20.6331","20.1143","20.7413",{"$nulls":3},"cellular protein modification process;endomitotic cell cycle;negative regulation of transcription, DNA-templated;NIK/NF-kappaB signaling;post-translational protein modification;protein neddylation;proteolysis;regulation of cell cycle","acid-amino acid ligase activity;ATP binding;identical protein binding;ligand-dependent nuclear receptor binding;NEDD8 activating enzyme activity;NEDD8 transferase activity;protein heterodimerization activity","cytoplasm;cytosol;nucleus","Ubiquitin mediated proteolysis",null,null,11,11,11,"39.1","39.1","39.1","51.852",0,"98.165",449060000,33,"0.828874",1,"1.00598","1.78801","sp|Q8TBC4|UBA3_HUMAN;tr|F8W8D4|F8W8D4_HUMAN;tr|F8WF86|F8WF86_HUMAN","sp|Q8TBC4|UBA3_HUMAN;tr|F8W8D4|F8W8D4_HUMAN",3543,"Q8TBC4","UBA3_HUMAN","NEDD8-activating enzyme E1 catalytic subunit",null,"UBA3"]
["18.4405","18.4887","17.0685","16.6918","17.7915","16.5019",{"$nulls":3},"activation of protein kinase activity;cell cycle;lymphocyte aggregation;neutrophil degranulation;protein autophosphorylation;protein phosphorylation;regulation of apoptotic process;regulation of lymphocyte migration;regulation of mitotic cell cycle;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;identical protein binding;protein homodimerization activity;protein serine/threonine kinase activity","cytoplasm;extracellular exosome;plasma membrane;specific granule membrane","Progesterone-mediated oocyte maturation",null,null,7,6,6,"9.1","8.2","8.2","112.13",0,"32.445",124780000,18,"0.749846",1,"1.00419","1.6326","sp|O94804|STK10_HUMAN","sp|O94804|STK10_HUMAN",676,"O94804","STK10_HUMAN","Serine/threonine-protein kinase 10",null,"STK10"]
["19.5489","18.5763","18.0416","18.7329","16.4272","17.9946",{"$nulls":3},"autophagy of mitochondrion;negative regulation of cyclin-dependent protein serine/threonine kinase activity;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of hydrogen peroxide-induced neuron death;negative regulation of lymphocyte differentiation;negative regulation of oxidative stress-induced neuron death;positive regulation of autophagy of mitochondrion;post-translational protein modification;protein polyubiquitination;protein targeting to mitochondrion;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of locomotion;regulation of neuron projection development;regulation of protein stability;ubiquitin-dependent protein catabolic process","protein heterodimerization activity;protein kinase binding;ubiquitin binding;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","classical Lewy body;cytoplasm;cytosol;glial cytoplasmic inclusion;Lewy body core;Lewy body corona;Lewy neurite;mitochondrion;nucleus;protein complex;SCF ubiquitin ligase complex;ubiquitin ligase complex",{"$nulls":3},3,3,3,"7.5","7.5","7.5","58.502",0,"6.9263",55432000,3,"0.548084",1,"1.00408","1.23898","sp|Q9Y3I1|FBX7_HUMAN","sp|Q9Y3I1|FBX7_HUMAN",5300,"Q9Y3I1","FBX7_HUMAN","F-box only protein 7",null,"FBXO7"]
["20.089","17.6393","19.5714","18.596","16.7602","18.9347",{"$nulls":3},"nitrogen compound metabolic process","nitrilase activity","extracellular exosome;mitochondrion;nucleus",{"$nulls":3},6,6,6,19,19,19,"35.896",0,"16.776",113600000,7,"0.425728",1,"1.00292","0.99696","sp|Q86X76|NIT1_HUMAN","sp|Q86X76|NIT1_HUMAN",3252,"Q86X76","NIT1_HUMAN","Deaminated glutathione amidase","GSH amidase","NIT1"]
["20.3151","18.365","19.2549","19.4559","15.7818","19.7025",{"$nulls":3},"protein complex assembly","beta-catenin binding;cadherin binding;phosphatase binding;protein complex scaffold activity;protein C-terminus binding;receptor binding","apical plasma membrane;endomembrane system;extracellular exosome;focal adhesion;nucleus;plasma membrane","Aldosterone-regulated sodium reabsorption",null,null,7,7,7,"25.8","25.8","25.8","37.413",0,"22.634",213140000,18,"0.291057",1,"0.998286","0.719524","sp|Q15599|NHRF2_HUMAN;tr|H3BN50|H3BN50_HUMAN;tr|H3BQS0|H3BQS0_HUMAN;tr|H3BUQ9|H3BUQ9_HUMAN;tr|H3BMF5|H3BMF5_HUMAN","sp|Q15599|NHRF2_HUMAN;tr|H3BN50|H3BN50_HUMAN;tr|H3BQS0|H3BQS0_HUMAN",2618,"Q15599","NHRF2_HUMAN","Na(+)/H(+) exchange regulatory cofactor NHE-RF2","HERF-2","SLC9A3R2"]
["21.2572","19.3542","20.1715","19.7524","18.3028","19.7335",{"$nulls":3},"cellular carbohydrate metabolic process;galactose catabolic process;glycosaminoglycan catabolic process;glycosphingolipid metabolic process;keratan sulfate catabolic process;neutrophil degranulation;response to cortisone;response to Thyroglobulin triiodothyronine","beta-galactosidase activity;exo-alpha-sialidase activity;galactoside binding","azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;Golgi apparatus;intracellular membrane-bounded organelle;lysosomal lumen;perinuclear region of cytoplasm;vacuole","Galactose metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - ganglio series;Lysosome;Metabolic pathways;Other glycan degradation;Sphingolipid metabolism",null,null,10,10,10,"18.2","18.2","18.2","76.074",0,"29.237",330450000,23,"0.612871",1,"0.99808","1.36547","sp|P16278|BGAL_HUMAN;tr|E7EQ29|E7EQ29_HUMAN;tr|C9J539|C9J539_HUMAN;tr|F8WF40|F8WF40_HUMAN;tr|C9JF15|C9JF15_HUMAN;tr|C9JWX1|C9JWX1_HUMAN;tr|C9J4G9|C9J4G9_HUMAN","sp|P16278|BGAL_HUMAN;tr|E7EQ29|E7EQ29_HUMAN",1133,"P16278","BGAL_HUMAN","Beta-galactosidase",null,"GLB1"]
["21.932","20.0795","21.1984","20.0503","19.6709","20.4978",{"$nulls":3},"DNA metabolic process;gene silencing by RNA;rRNA 3'-end processing;rRNA processing","3'-5' exonuclease activity;3'-5'-exoribonuclease activity;histone pre-mRNA stem-loop binding;metal ion binding;ribosome binding;rRNA binding","cytoplasm;histone pre-mRNA 3'end processing complex;nucleolus;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"17.5","17.5","17.5","40.063",0,"18.086",689340000,69,"0.780114",1,"0.99696","1.69194","sp|Q8IV48|ERI1_HUMAN;tr|E5RIV7|E5RIV7_HUMAN","sp|Q8IV48|ERI1_HUMAN",3287,"Q8IV48","ERI1_HUMAN","3'-5' exoribonuclease 1",null,"ERI1"]
["21.3474","18.7946","19.3445","18.1033","18.8866","19.5079",{"$nulls":3},"carbohydrate metabolic process;glucosamine catabolic process;N-acetylglucosamine metabolic process","glucosamine-6-phosphate deaminase activity","cytosol;nucleus","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,9,5,5,"56.5","34.8","34.8","31.084",0,"56.074",122300000,14,"0.496482",1,"0.996201","1.13762","sp|Q8TDQ7|GNPI2_HUMAN","sp|Q8TDQ7|GNPI2_HUMAN",3566,"Q8TDQ7","GNPI2_HUMAN","Glucosamine-6-phosphate isomerase 2",null,"GNPDA2"]
["21.4582","21.1088","20.7063","20.5609","19.8216","19.9027",{"$nulls":3},"protein targeting to mitochondrion",null,"integral component of membrane;mitochondrial outer membrane",{"$nulls":3},7,7,7,"19.5","19.5","19.5","51.462",0,"33.356",326890000,21,"1.44907",1,"0.996098","3.1191","tr|A0A0A0MRK6|A0A0A0MRK6_HUMAN;sp|Q13505|MTX1_HUMAN;tr|A0A0C4DFQ1|A0A0C4DFQ1_HUMAN","tr|A0A0A0MRK6|A0A0A0MRK6_HUMAN;sp|Q13505|MTX1_HUMAN;tr|A0A0C4DFQ1|A0A0C4DFQ1_HUMAN",2370,"A0A0A0MRK6","A0A0A0MRK6_HUMAN"]
["17.6717","18.2412","17.1495","18.0788","15.5181","16.4795",{"$nulls":3},"adenosine to inosine editing;base conversion or substitution editing;cellular response to virus;defense response to virus;definitive hemopoiesis;erythrocyte differentiation;hematopoietic progenitor cell differentiation;hematopoietic stem cell homeostasis;in utero embryonic development;innate immune response;miRNA loading onto RISC involved in gene silencing by miRNA;mRNA processing;negative regulation of apoptotic process;negative regulation of protein kinase activity by regulation of protein phosphorylation;negative regulation of RNA interference;negative regulation of type I interferon-mediated signaling pathway;negative regulation of viral genome replication;osteoblast differentiation;positive regulation of viral genome replication;pre-miRNA processing;protein export from nucleus;protein import into nucleus;response to interferon-alpha;response to virus;somatic diversification of immune receptors via somatic mutation;type I interferon signaling pathway","DNA binding;double-stranded RNA adenosine deaminase activity;metal ion binding;RNA binding","cytoplasm;membrane;nucleolus;nucleoplasm;nucleus;supraspliceosomal complex","Cytosolic DNA-sensing pathway;Influenza A;Measles",null,null,7,7,7,"7.5","7.5","7.5","136.06",0,"19.844",187180000,21,"0.542398",1,"0.995343","1.22785","sp|P55265|DSRAD_HUMAN;tr|H0YCK3|H0YCK3_HUMAN","sp|P55265|DSRAD_HUMAN;tr|H0YCK3|H0YCK3_HUMAN",1847,"P55265","DSRAD_HUMAN","Double-stranded RNA-specific adenosine deaminase","RADA {ECO:0000303|PubMed:7972084}","ADAR"]
["26.3198","25.3436","25.6606","25.0944","24.2826","24.9625",{"$nulls":3},"DNA replication;mitochondrion morphogenesis;mitochondrion organization;positive regulation of helicase activity","chromatin binding;RNA binding;single-stranded DNA binding","extracellular exosome;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleus","DNA replication;Homologous recombination;Mismatch repair",null,null,8,8,8,"56.1","56.1","56.1","17.259",0,"233.53",3556900000,103,"1.22339",1,"0.994826","2.60413","sp|Q04837|SSBP_HUMAN;tr|A0A0G2JLD8|A0A0G2JLD8_HUMAN;tr|E7EUY5|E7EUY5_HUMAN;tr|C9K0U8|C9K0U8_HUMAN","sp|Q04837|SSBP_HUMAN;tr|A0A0G2JLD8|A0A0G2JLD8_HUMAN;tr|E7EUY5|E7EUY5_HUMAN;tr|C9K0U8|C9K0U8_HUMAN",2188,"Q04837","SSBP_HUMAN","Single-stranded DNA-binding protein, mitochondrial","tSSB;t-SSB","SSBP1"]
["23.5679","22.3969","22.8925","22.2848","21.7707","21.8215",{"$nulls":3},"alcohol metabolic process;carbohydrate metabolic process;ethanol catabolic process;ethanol oxidation","aldehyde dehydrogenase (NAD) activity;aldehyde dehydrogenase [NAD(P)+] activity;electron transfer activity;NAD binding","extracellular exosome;mitochondrial matrix","Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Fatty acid degradation;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Lysine degradation;Metabolic pathways;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,23,21,19,"55.1","53.4","50.5","56.381",0,"148.71",1740600000,105,"1.23836",1,"0.993424","2.63699","sp|P05091|ALDH2_HUMAN;tr|F8VP50|F8VP50_HUMAN;tr|S4R3S4|S4R3S4_HUMAN;tr|H0YKL3|H0YKL3_HUMAN","sp|P05091|ALDH2_HUMAN",891,"P05091","ALDH2_HUMAN","Aldehyde dehydrogenase, mitochondrial",null,"ALDH2"]
["19.6005","17.7982","18.1726","17.1674","17.1366","18.2901",{"$nulls":3},"cellular protein metabolic process;intracellular protein transport;positive regulation of protein catabolic process;vesicle-mediated transport","ADP-ribosylation factor binding","clathrin adaptor complex;early endosome membrane;endosome membrane;Golgi apparatus;recycling endosome membrane;trans-Golgi network","Lysosome",null,null,10,10,9,18,18,17,"78.314",0,"24.227",138780000,20,"0.675159",1,"0.992371","1.48679","sp|Q9NZ52|GGA3_HUMAN;tr|J3KSS7|J3KSS7_HUMAN;tr|J3QRS8|J3QRS8_HUMAN;tr|B7Z1E9|B7Z1E9_HUMAN;tr|J3QS87|J3QS87_HUMAN;tr|J3KSG3|J3KSG3_HUMAN;tr|J3QRP3|J3QRP3_HUMAN;tr|J3KS27|J3KS27_HUMAN;tr|J3QRK7|J3QRK7_HUMAN;tr|J3KTR5|J3KTR5_HUMAN","sp|Q9NZ52|GGA3_HUMAN;tr|J3KSS7|J3KSS7_HUMAN",4868,"Q9NZ52","GGA3_HUMAN","ADP-ribosylation factor-binding protein GGA3",null,"GGA3"]
["23.0709","21.0876","22.6546","23.0533","18.1204","22.6652",{"$nulls":4},"peptidyl-prolyl cis-trans isomerase activity",{"$nulls":4},5,5,5,"71.1","71.1","71.1","9.8329",0,"48.217",210670000,21,"0.229164",1,"0.991391","0.584965","tr|K7EN45|K7EN45_HUMAN;sp|Q13526|PIN1_HUMAN;tr|K7EMU7|K7EMU7_HUMAN","tr|K7EN45|K7EN45_HUMAN;sp|Q13526|PIN1_HUMAN;tr|K7EMU7|K7EMU7_HUMAN",2375,"K7EN45","K7EN45_HUMAN","Peptidyl-prolyl cis-trans isomerase {ECO:0000256|RuleBase:RU363014}",null,"PIN1"]
["21.6759","21.4416","20.8802","20.8377","19.8021","20.3902",{"$nulls":5},"integral component of membrane;mitochondrion",{"$nulls":3},9,9,9,"25.5","25.5","25.5","45.811",0,"111.32",362070000,26,"1.21784",1,"0.989243","2.592","sp|Q96ER9|CCD51_HUMAN;tr|C9JSW8|C9JSW8_HUMAN;tr|C9JPZ8|C9JPZ8_HUMAN","sp|Q96ER9|CCD51_HUMAN",3862,"Q96ER9","CCD51_HUMAN","Coiled-coil domain-containing protein 51",null,"CCDC51"]
["21.2163","20.9933","20.3577","19.1192","20.0975","20.3854",{"$nulls":5},"mitochondrion;nuclear body",{"$nulls":3},3,3,3,"31.7","31.7","31.7","11.909",0,"9.7359",116690000,13,"1.0047",1,"0.988344","2.14148","tr|Q5TAQ0|Q5TAQ0_HUMAN;tr|V5IRT4|V5IRT4_HUMAN;sp|Q9BRT2|UQCC2_HUMAN","tr|Q5TAQ0|Q5TAQ0_HUMAN;tr|V5IRT4|V5IRT4_HUMAN;sp|Q9BRT2|UQCC2_HUMAN",4173,"Q5TAQ0","Q5TAQ0_HUMAN",null,null,"UQCC2"]
["20.1192","19.9415",1,"18.8154","18.2856",1,{"$nulls":9},1,1,1,"17.2","17.2","17.2","9.8382","0.0011788","3.3003",15708000,3,"0.0388146",1,"0.98654","0.114305","tr|H0Y362|H0Y362_HUMAN;sp|Q8NEW0|ZNT7_HUMAN","tr|H0Y362|H0Y362_HUMAN;sp|Q8NEW0|ZNT7_HUMAN",3494,"H0Y362","H0Y362_HUMAN",null,null,"SLC30A7"]
["22.3136","19.9631","18.2997","20.8155","18.8757","17.9342",{"$nulls":9},4,4,4,"26.4","26.4","26.4","23.889",0,"52.743",151030000,10,"0.273931",1,"0.983712","0.682862","sp|Q6P1X6|CH082_HUMAN;tr|H0YF29|H0YF29_HUMAN","sp|Q6P1X6|CH082_HUMAN;tr|H0YF29|H0YF29_HUMAN",3006,"Q6P1X6","CH082_HUMAN","UPF0598 protein C8orf82",null,"C8orf82"]
["20.482","17.714","18.5956","18.9554","16.7798","18.1074",{"$nulls":3},"mitochondrial fission;mitochondrial fragmentation involved in apoptotic process;mitochondrial fusion;mitochondrion morphogenesis;peroxisome fission;positive regulation of mitochondrial fission;positive regulation of protein targeting to membrane;positive regulation of release of cytochrome c from mitochondria;protein homooligomerization;protein targeting to mitochondrion;regulation of mitochondrion organization;regulation of peroxisome organization;release of cytochrome c from mitochondria","protein homodimerization activity","cell junction;integral component of mitochondrial membrane;mitochondrial outer membrane;mitochondrion;peroxisome;synaptic vesicle",{"$nulls":3},3,3,3,"19.3","19.3","19.3","38.464",0,"45.913",73903000,8,"0.403151",1,"0.98301","0.951505","sp|Q9GZY8|MFF_HUMAN;tr|C9JHF5|C9JHF5_HUMAN;tr|A0A0A0MS29|A0A0A0MS29_HUMAN;tr|C9JU19|C9JU19_HUMAN;tr|E9PQX8|E9PQX8_HUMAN;tr|H7C433|H7C433_HUMAN","sp|Q9GZY8|MFF_HUMAN;tr|C9JHF5|C9JHF5_HUMAN;tr|A0A0A0MS29|A0A0A0MS29_HUMAN",4372,"Q9GZY8","MFF_HUMAN","Mitochondrial fission factor",null,"MFF"]
["23.0592","21.0716","22.283","22.6689","19.0102","21.7902",{"$nulls":3},"cristae formation",null,"MICOS complex;mitochondrial crista junction;mitochondrial inner membrane;mitochondrion;nucleoplasm",{"$nulls":3},3,3,3,"41.5","41.5","41.5","13.087",0,"60.169",208740000,26,"0.323641",1,"0.981502","0.788258","sp|Q5XKP0|MIC13_HUMAN;tr|K7EIR2|K7EIR2_HUMAN","sp|Q5XKP0|MIC13_HUMAN",2916,"Q5XKP0","MIC13_HUMAN","MICOS complex subunit MIC13 {ECO:0000305}",null,"MIC13"]
["20.8984","19.8819","19.1588","19.1801","19.2637","18.5583",{"$nulls":3},"positive regulation of transcription, DNA-templated","DNA binding;metal ion binding;RNA binding","cytoplasm;nucleoplasm;nucleus","Basal transcription factors;Transcriptional misregulation in cancer",null,null,7,5,5,"20.1","16.2","16.2","61.829",0,"193.72",655150000,22,"0.822458",1,"0.979001","1.77533","sp|Q92804|RBP56_HUMAN;tr|A0A075B7D9|A0A075B7D9_HUMAN;tr|A0A075B7F4|A0A075B7F4_HUMAN;tr|A0A075B7F2|A0A075B7F2_HUMAN","sp|Q92804|RBP56_HUMAN;tr|A0A075B7D9|A0A075B7D9_HUMAN",3718,"Q92804","RBP56_HUMAN","TATA-binding protein-associated factor 2N",null,"TAF15"]
["19.0586","17.6126","19.6048","18.5773","15.8454","18.9168",{"$nulls":9},4,3,3,"21.5","17.1","17.1","25.411",0,"5.9554",68920000,2,"0.357772",1,"0.97881","0.859021","tr|C9JRD2|C9JRD2_HUMAN;tr|C9JXB9|C9JXB9_HUMAN;sp|P25686|DNJB2_HUMAN;tr|C9J1G2|C9J1G2_HUMAN;tr|E7ETU0|E7ETU0_HUMAN;tr|C9JX00|C9JX00_HUMAN","tr|C9JRD2|C9JRD2_HUMAN;tr|C9JXB9|C9JXB9_HUMAN;sp|P25686|DNJB2_HUMAN;tr|C9J1G2|C9J1G2_HUMAN;tr|E7ETU0|E7ETU0_HUMAN;tr|C9JX00|C9JX00_HUMAN",1293,"C9JRD2","C9JRD2_HUMAN",null,null,"DNAJB2"]
["21.153","19.3971","18.8954","20.0356","18.599","17.8812",{"$nulls":3},"nitrate assimilation;sulfide oxidation, using sulfide:quinone oxidoreductase","heme binding;molybdenum ion binding;molybdopterin cofactor binding;sulfite oxidase activity","mitochondrial intermembrane space;mitochondrial matrix","Metabolic pathways;Sulfur metabolism",null,null,10,10,10,"31.6","31.6","31.6","60.282",0,"110.8",238210000,28,"0.45088",1,"0.976561","1.04724","sp|P51687|SUOX_HUMAN","sp|P51687|SUOX_HUMAN",1752,"P51687","SUOX_HUMAN","Sulfite oxidase, mitochondrial",null,"SUOX"]
["22.8433","19.866","20.8052","21.6581","19.4031","19.5254",{"$nulls":3},"ubiquitin-dependent protein catabolic process",{"$nulls":5},3,3,3,"51.7","51.7","51.7","9.9601",0,"12.525",135730000,14,"0.354997",1,"0.976009","0.853308","tr|E5RHG8|E5RHG8_HUMAN;sp|Q15369|ELOC_HUMAN;tr|R4GMY8|R4GMY8_HUMAN","tr|E5RHG8|E5RHG8_HUMAN;sp|Q15369|ELOC_HUMAN;tr|R4GMY8|R4GMY8_HUMAN",2588,"E5RHG8","E5RHG8_HUMAN",null,null,"ELOC"]
["17.9744","16.4157","16.3491","17.5636","14.1185","16.1297",{"$nulls":3},"glycoside catabolic process;glycosphingolipid catabolic process;glycosphingolipid metabolic process;glycosylceramide catabolic process;negative regulation of nitric oxide biosynthetic process;negative regulation of nitric-oxide synthase activity;neutrophil degranulation;oligosaccharide metabolic process","alpha-galactosidase activity;catalytic activity;galactoside binding;hydrolase activity;protein homodimerization activity;raffinose alpha-galactosidase activity;receptor binding","azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;Golgi apparatus;lysosomal lumen;lysosome","Galactose metabolism;Glycerolipid metabolism;Glycosphingolipid biosynthesis - globo and isoglobo series;Lysosome;Metabolic pathways;Sphingolipid metabolism",null,null,4,4,4,10,10,10,"48.766",0,"8.4574",36574000,5,"0.35942",1,"0.97583","0.862407","sp|P06280|AGAL_HUMAN","sp|P06280|AGAL_HUMAN",909,"P06280","AGAL_HUMAN","Alpha-galactosidase A",null,"GLA"]
["24.8884","23.8745","23.7499","23.8239","22.2169","23.5453",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA processing;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;negative regulation of protein ubiquitination;positive regulation of protein targeting to mitochondrion;positive regulation of RNA splicing;regulation of autophagy of mitochondrion;RNA export from nucleus;termination of RNA polymerase II transcription","C2H2 zinc finger domain binding;enzyme binding;poly-pyrimidine tract binding;pre-mRNA 3'-splice site binding;RNA binding","commitment complex;nuclear speck;nucleoplasm;nucleus;spliceosomal complex;U2AF;U2-type prespliceosome","Spliceosome",null,null,14,14,14,"51.8","51.8","51.8","53.5",0,"164.13",2427700000,144,"0.728773",1,"0.975557","1.59138","sp|P26368|U2AF2_HUMAN;tr|K7ENG2|K7ENG2_HUMAN;tr|K7ELP8|K7ELP8_HUMAN","sp|P26368|U2AF2_HUMAN;tr|K7ENG2|K7ENG2_HUMAN",1305,"P26368","U2AF2_HUMAN","Splicing factor U2AF 65 kDa subunit",null,"U2AF2"]
["23.3264","21.5313","22.4668","22.1937","20.2771","21.9282",{"$nulls":3},"creatine metabolic process","ATP binding;creatine kinase activity","extracellular exosome;mitochondrial inner membrane;mitochondrion","Arginine and proline metabolism;Metabolic pathways",null,null,15,15,15,47,47,47,"47.036",0,"272.35",885050000,63,"0.543674",1,"0.975131","1.23035","sp|P12532|KCRU_HUMAN;tr|F8WCN3|F8WCN3_HUMAN;tr|C9JSQ1|C9JSQ1_HUMAN;tr|C9J995|C9J995_HUMAN;tr|C9J8F6|C9J8F6_HUMAN;tr|C9JJX8|C9JJX8_HUMAN;tr|C9J6W7|C9J6W7_HUMAN;tr|C9JT96|C9JT96_HUMAN;sp|P17540|KCRS_HUMAN","sp|P12532|KCRU_HUMAN;tr|F8WCN3|F8WCN3_HUMAN",1067,"P12532","KCRU_HUMAN","Creatine kinase U-type, mitochondrial",null,"CKMT1A;CKMT1B"]
["21.2273","20.3726","20.5513","18.45","20.2174","20.5605",{"$nulls":3},"cell differentiation;cell proliferation;regulation of myeloid cell differentiation;transcription, DNA-templated","mRNA binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;single-stranded DNA binding;SMAD binding;transcription factor binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","DNA replication factor A complex;nucleus",{"$nulls":3},3,3,3,"27.6","27.6","27.6","33.24",0,"11.06",127150000,12,"0.622721",1,"0.97444","1.38466","sp|Q96QR8|PURB_HUMAN","sp|Q96QR8|PURB_HUMAN",4010,"Q96QR8","PURB_HUMAN","Transcriptional activator protein Pur-beta",null,"PURB"]
["20.2388","18.8745","19.7366","18.5118","18.2218","19.2122",{"$nulls":3},"immunoglobulin biosynthetic process;O-glycan processing;protein O-linked glycosylation;protein O-linked glycosylation via serine;protein O-linked glycosylation via threonine","carbohydrate binding;manganese ion binding;polypeptide N-acetylgalactosaminyltransferase activity","endoplasmic reticulum membrane;extracellular exosome;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;Golgi stack;integral component of Golgi membrane;membrane;perinuclear region of cytoplasm","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,10,10,9,"22.1","22.1","20.3","64.732",0,"39.235",204400000,27,"0.912871",1,"0.96806","1.95527","sp|Q10471|GALT2_HUMAN","sp|Q10471|GALT2_HUMAN",2250,"Q10471","GALT2_HUMAN","Polypeptide N-acetylgalactosaminyltransferase 2",null,"GALNT2"]
["23.5455","22.1377","22.6725","22.1971","21.2421","22.0167",{"$nulls":3},"positive regulation of cell motility;regulation of transcription, DNA-templated;rRNA transcription;termination of RNA polymerase I transcription;transcription initiation from RNA polymerase I promoter","identical protein binding;RNA binding;rRNA primary transcript binding","caveola;cytoplasm;cytosol;endoplasmic reticulum;intracellular membrane-bounded organelle;membrane raft;mitochondrion;nucleoplasm;nucleus;plasma membrane;protein complex",{"$nulls":3},18,18,18,"46.7","46.7","46.7","43.476",0,"323.31",5307000000,321,"0.893999",1,"0.966612","1.91746","sp|Q6NZI2|PTRF_HUMAN","sp|Q6NZI2|PTRF_HUMAN",2991,"Q6NZI2","CAVN1_HUMAN","Caveolae-associated protein 1 {ECO:0000312|HGNC:HGNC:9688}",null,"CAVIN1"]
["20.9805","18.573","20.7534","19.7118","17.5312","20.1658",{"$nulls":3},"learning;memory;negative regulation of synaptic transmission, glutamatergic;positive regulation of receptor internalization","ATP binding;ATPase activity","cell junction;membrane;mitochondrion;nucleus;peroxisomal membrane;postsynaptic membrane",{"$nulls":3},7,7,7,"24.9","24.9","24.9","40.744",0,"30.275",220340000,16,"0.360156",1,"0.965983","0.863922","sp|Q8NBU5|ATAD1_HUMAN","sp|Q8NBU5|ATAD1_HUMAN",3464,"Q8NBU5","ATAD1_HUMAN","ATPase family AAA domain-containing protein 1",null,"ATAD1"]
["15.7145","14.9816","15.5622","14.8896","13.0712","15.4037",{"$nulls":3},"valyl-tRNA aminoacylation","aminoacyl-tRNA editing activity;ATP binding;valine-tRNA ligase activity",{"$nulls":4},2,2,2,"2.5","2.5","2.5","118.37","0.0013635","3.2094",18631000,2,"0.57934",1,"0.964579","1.30008","tr|B7ZL25|B7ZL25_HUMAN;tr|A0A0A0MTG1|A0A0A0MTG1_HUMAN;tr|B4E0K6|B4E0K6_HUMAN;tr|A0A0G2JIA5|A0A0G2JIA5_HUMAN;sp|Q5ST30|SYVM_HUMAN;tr|A0A0G2JL52|A0A0G2JL52_HUMAN","tr|B7ZL25|B7ZL25_HUMAN;tr|A0A0A0MTG1|A0A0A0MTG1_HUMAN;tr|B4E0K6|B4E0K6_HUMAN;tr|A0A0G2JIA5|A0A0G2JIA5_HUMAN;sp|Q5ST30|SYVM_HUMAN;tr|A0A0G2JL52|A0A0G2JL52_HUMAN",2850,"B7ZL25","B7ZL25_HUMAN"]
["21.6129","19.7572","21.0564","19.4572","19.358","20.7208",{"$nulls":3},"cellular response to DNA damage stimulus",null,"nucleus",{"$nulls":3},6,6,6,"38.9","38.9","38.9","24.178",0,"49.28",198120000,24,"0.615104",1,"0.963464","1.36982","sp|Q9GZP4|PITH1_HUMAN;tr|X6R8S9|X6R8S9_HUMAN;tr|X6RHB9|X6RHB9_HUMAN","sp|Q9GZP4|PITH1_HUMAN;tr|X6R8S9|X6R8S9_HUMAN",4361,"Q9GZP4","PITH1_HUMAN","PITH domain-containing protein 1",null,"PITHD1"]
["19.5887","18.8737","18.3337","17.3576","18.3516","18.1979",{"$nulls":3},"proteolysis;regulation of cellular protein metabolic process","dipeptidase activity","extracellular exosome;nucleoplasm",{"$nulls":3},3,3,3,"8.9","8.9","8.9","47.776",0,"10.623",73238000,11,"0.944467",1,"0.963025","2.0189","sp|Q8IYS1|P20D2_HUMAN","sp|Q8IYS1|P20D2_HUMAN",3344,"Q8IYS1","P20D2_HUMAN","Peptidase M20 domain-containing protein 2",null,"PM20D2"]
["17.107","14.0223","18.1748","15.887","14.8282","15.7049",{"$nulls":3},"anterograde axonal transport;antigen processing and presentation of exogenous peptide antigen via MHC class II;determination of left/right symmetry;intraciliary transport involved in cilium assembly;microtubule-based movement;mitotic centrosome separation;mitotic spindle assembly;mitotic spindle organization;plus-end-directed vesicle transport along microtubule;positive regulation of cytokinesis;retrograde vesicle-mediated transport, Golgi to ER","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;microtubule binding;microtubule motor activity;Rho GTPase binding","axon cytoplasm;centrosome;ciliary tip;cilium;cytosol;extracellular exosome;intraciliary transport particle;kinesin II complex;membrane;microtubule;microtubule cytoskeleton;midbody;plus-end kinesin complex;spindle",{"$nulls":3},4,4,4,7,7,7,"85.124",0,"6.813",55030000,5,"0.30394",1,"0.96132","0.746851","sp|O15066|KIF3B_HUMAN;tr|F8WAR6|F8WAR6_HUMAN;tr|F8WER6|F8WER6_HUMAN;tr|A0A087WX26|A0A087WX26_HUMAN;sp|O14782|KIF3C_HUMAN;tr|H3BTL6|H3BTL6_HUMAN;tr|B7Z896|B7Z896_HUMAN;tr|F5H3M2|F5H3M2_HUMAN;sp|Q9BVG8|KIFC3_HUMAN;tr|A0A0A0MRS8|A0A0A0MRS8_HUMAN;sp|Q9P2E2|KIF17_HUMAN","sp|O15066|KIF3B_HUMAN;tr|F8WAR6|F8WAR6_HUMAN;tr|F8WER6|F8WER6_HUMAN;tr|A0A087WX26|A0A087WX26_HUMAN;sp|O14782|KIF3C_HUMAN",328,"O15066","KIF3B_HUMAN","Kinesin-like protein KIF3B",null,"KIF3B"]
["20.0772","19.2309","18.8532","18.7167","18.1243","18.4381",{"$nulls":9},2,2,2,"16.4","16.4","16.4","17.789",0,"7.6427",41584000,10,"1.12881",1,"0.960738","2.40028","tr|B1AMU7|B1AMU7_HUMAN;tr|B1AMU3|B1AMU3_HUMAN;sp|Q9Y3B2|EXOS1_HUMAN;tr|R4GNH9|R4GNH9_HUMAN;tr|R4GMQ7|R4GMQ7_HUMAN;tr|B1AMU4|B1AMU4_HUMAN","tr|B1AMU7|B1AMU7_HUMAN;tr|B1AMU3|B1AMU3_HUMAN;sp|Q9Y3B2|EXOS1_HUMAN;tr|R4GNH9|R4GNH9_HUMAN;tr|R4GMQ7|R4GMQ7_HUMAN;tr|B1AMU4|B1AMU4_HUMAN",5281,"B1AMU7","B1AMU7_HUMAN",null,null,"EXOSC1"]
["18.4204","17.1691","15.7769","18.2967","14.885","15.3035",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding","cytosol;nucleus",{"$nulls":3},5,5,4,"8.9","8.9","7.8","91.43",0,"31.559",64990000,10,"0.295361",1,"0.960374","0.728678","tr|E7EWK3|E7EWK3_HUMAN;sp|Q9H2U1|DHX36_HUMAN;tr|A0A0G2JRP3|A0A0G2JRP3_HUMAN;tr|A0A0G2JQU7|A0A0G2JQU7_HUMAN","tr|E7EWK3|E7EWK3_HUMAN;sp|Q9H2U1|DHX36_HUMAN",4437,"E7EWK3","E7EWK3_HUMAN",null,null,"DHX36"]
["20.1259","16.5035","18.6817","19.014","15.5737","17.8454",{"$nulls":3},"acrosome assembly;adherens junction organization;adhesion of symbiont to host;cell part morphogenesis;cell recognition;cilium organization;coreceptor-mediated virion attachment to host cell;cytoskeleton organization;establishment of mitochondrion localization;fertilization;fusion of virus membrane with host plasma membrane;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;homophilic cell adhesion via plasma membrane adhesion molecules;positive regulation of immunoglobulin mediated immune response;positive regulation of mast cell activation;positive regulation of natural killer cell mediated cytotoxicity;positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;positive regulation of T cell receptor signaling pathway;regulation of immune response;regulation of viral entry into host cell;sperm mitochondrion organization;spermatid development;spermatid nucleus differentiation;susceptibility to natural killer cell mediated cytotoxicity;susceptibility to T cell mediated cytotoxicity","cell adhesion molecule binding;coreceptor activity;identical protein binding;protein heterodimerization activity;protein homodimerization activity;receptor binding;virus receptor activity","cell surface;cell-cell adherens junction;cell-cell contact zone;cell-cell junction;extracellular exosome;focal adhesion;integral component of membrane;integral component of plasma membrane;plasma membrane;zonula adherens","Adherens junction;Cell adhesion molecules (CAMs)",null,null,9,9,9,"23.8","23.8","23.8","57.741",0,"26.88",99452000,13,"0.262219",1,"0.959335","0.657552","sp|Q92692|PVRL2_HUMAN;tr|K7EKE8|K7EKE8_HUMAN","sp|Q92692|PVRL2_HUMAN;tr|K7EKE8|K7EKE8_HUMAN",3704,"Q92692","NECT2_HUMAN","Nectin-2",null,"NECTIN2"]
["24.5931","23.2957","23.8843","23.621","22.1254","23.1533",{"$nulls":3},"cardiolipin acyl-chain remodeling;fatty acid beta-oxidation","3-hydroxyacyl-CoA dehydrogenase activity;acetyl-CoA C-acyltransferase activity;enoyl-CoA hydratase activity;long-chain-3-hydroxyacyl-CoA dehydrogenase activity;RNA binding","endoplasmic reticulum;extracellular exosome;mitochondrial envelope;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrial outer membrane;mitochondrion","Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,22,22,22,"58.6","58.6","58.6","51.294",0,"323.31",10979000000,423,"0.760228",1,"0.957818","1.65293","sp|P55084|ECHB_HUMAN;tr|F5GZQ3|F5GZQ3_HUMAN;tr|B5MD38|B5MD38_HUMAN;tr|C9JEY0|C9JEY0_HUMAN;tr|C9JE81|C9JE81_HUMAN;tr|C9K0M0|C9K0M0_HUMAN","sp|P55084|ECHB_HUMAN;tr|F5GZQ3|F5GZQ3_HUMAN;tr|B5MD38|B5MD38_HUMAN",1838,"P55084","ECHB_HUMAN","Trifunctional enzyme subunit beta, mitochondrial",null,"HADHB"]
["21.141","19.2514","19.8033","18.4388","19.5769","19.3068",{"$nulls":5},"integral component of membrane",{"$nulls":3},5,5,5,"8.1","8.1","8.1","67.887",0,"10.397",171660000,16,"0.659447",1,"0.957706","1.45619","sp|Q9HD45|TM9S3_HUMAN;tr|Q5TB53|Q5TB53_HUMAN","sp|Q9HD45|TM9S3_HUMAN;tr|Q5TB53|Q5TB53_HUMAN",4612,"Q9HD45","TM9S3_HUMAN","Transmembrane 9 superfamily member 3",null,"TM9SF3"]
["20.3565","16.1932","20.1312","17.8228","15.9667","20.0222",{"$nulls":3},"transcription, DNA-templated;transforming growth factor beta receptor signaling pathway","DNA binding;DNA binding transcription factor activity","centrosome;cytosol;nucleoplasm;transcription factor complex",{"$nulls":3},5,5,5,"20.2","20.2","20.2","50.052",0,"21.204",101630000,10,"0.206712",1,"0.956423","0.534566","tr|K7EIU8|K7EIU8_HUMAN;sp|Q13485|SMAD4_HUMAN;tr|K7ES96|K7ES96_HUMAN;tr|K7ELK2|K7ELK2_HUMAN;tr|K7EL18|K7EL18_HUMAN;tr|K7EIJ2|K7EIJ2_HUMAN;tr|K7ENG8|K7ENG8_HUMAN;tr|A0A087WUF3|A0A087WUF3_HUMAN","tr|K7EIU8|K7EIU8_HUMAN;sp|Q13485|SMAD4_HUMAN;tr|K7ES96|K7ES96_HUMAN",2367,"K7EIU8","K7EIU8_HUMAN","Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195}","AD homolog {ECO:0000256|RuleBase:RU361195};others against DPP homolog {ECO:0000256|RuleBase:RU361195}","SMAD4"]
["22.2636","15.093",1,1,"15.4254","19.0687",{"$nulls":9},12,2,2,"59.4","14.6","14.6","22.692",0,"74.564",250530000,15,"0.0388846",1,"0.954201","0.114504","tr|B1ALG6|B1ALG6_HUMAN","tr|B1ALG6|B1ALG6_HUMAN",5473,"B1ALG6","B1ALG6_HUMAN",null,null,"HELLS"]
["19.1082","17.5734","17.3023","17.1232","16.8627","17.1357",{"$nulls":3},"adaptive immune response;antigen processing and presentation of endogenous peptide antigen via MHC class I;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of peptide antigen via MHC class I;cytosol to ER transport;defense response;peptide transport;protein transport;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;viral process","ADP binding;ATP binding;MHC class I protein binding;MHC class Ib protein binding;peptide antigen binding;peptide transporter activity;peptide-transporting ATPase activity;protein homodimerization activity;TAP1 binding;TAP2 binding","endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;integral component of endoplasmic reticulum membrane;integral component of membrane;membrane;microtubule organizing center;mitochondrion;phagocytic vesicle membrane;TAP complex","ABC transporters;Antigen processing and presentation;Epstein-Barr virus infection;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Phagosome;Primary immunodeficiency",null,null,3,3,3,"6.8","6.8","6.8","87.217",0,"19.737",89977000,8,"0.77204",1,"0.954114","1.67609","sp|Q03518|TAP1_HUMAN","sp|Q03518|TAP1_HUMAN",2179,"Q03518","TAP1_HUMAN","Antigen peptide transporter 1","PT1","TAP1"]
["18.3348","20.8674","21.3072","20.9084","19.3556","17.3837",{"$nulls":5},"MICOS complex",{"$nulls":3},3,3,3,"35.7","35.7","35.7","15.303",0,"11.151",92088000,7,"0.278358",1,"0.953904","0.692378","tr|J3QTB2|J3QTB2_HUMAN;sp|Q9BRQ6|MIC25_HUMAN;tr|J3QTA6|J3QTA6_HUMAN;tr|H0Y922|H0Y922_HUMAN","tr|J3QTB2|J3QTB2_HUMAN;sp|Q9BRQ6|MIC25_HUMAN;tr|J3QTA6|J3QTA6_HUMAN",4168,"J3QTB2","J3QTB2_HUMAN","MICOS complex subunit {ECO:0000256|RuleBase:RU363001}",null,"CHCHD6"]
["23.3279","20.9666","21.6756","21.6446","20.3217","21.1424",{"$nulls":9},8,8,8,"21.9","21.9","21.9","60.457",0,"117.1",667080000,48,"0.525185",1,"0.953795","1.1941","tr|A0A0C4DGZ9|A0A0C4DGZ9_HUMAN;sp|O14773|TPP1_HUMAN;tr|E7EV34|E7EV34_HUMAN","tr|A0A0C4DGZ9|A0A0C4DGZ9_HUMAN;sp|O14773|TPP1_HUMAN",293,"A0A0C4DGZ9"]
[1,"17.1672","16.6693",1,"13.9673","17.0081",{"$nulls":5},"cis-Golgi network;endocytic vesicle;endosome membrane;Golgi apparatus;Golgi cisterna membrane;Golgi lumen;Golgi membrane;integral component of membrane;membrane;transport vesicle",{"$nulls":3},7,7,7,"12.1","12.1","12.1","81.879",0,"31.355",176170000,12,"0.0450724",1,"0.953693","0.131915","sp|O00461|GOLI4_HUMAN;tr|F8W785|F8W785_HUMAN","sp|O00461|GOLI4_HUMAN;tr|F8W785|F8W785_HUMAN",242,"O00461","GOLI4_HUMAN","Golgi integral membrane protein 4",null,"GOLIM4"]
["23.5424","22.2171","22.3361","22.3591","20.6964","22.1791",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,3,3,3,"28.6","28.6","28.6","11.402",0,"9.5001",362070000,17,"0.636318",1,"0.953657","1.41114","sp|O43676|NDUB3_HUMAN;tr|C9JKQ2|C9JKQ2_HUMAN","sp|O43676|NDUB3_HUMAN;tr|C9JKQ2|C9JKQ2_HUMAN",442,"O43676","NDUB3_HUMAN","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3",null,"NDUFB3"]
["22.3423","21.2362","21.638","19.9523","20.5786","21.8249",{"$nulls":3},"ubiquitin-dependent ERAD pathway","ubiquitin protein ligase binding","cytosol;endoplasmic reticulum;plasma membrane",{"$nulls":3},9,9,7,"38.2","38.2","31.1","37.725",0,"41.153",718170000,36,"0.678853",1,"0.953562","1.49399","tr|E5RHW4|E5RHW4_HUMAN;sp|O94905|ERLN2_HUMAN;tr|E5RJ09|E5RJ09_HUMAN","tr|E5RHW4|E5RHW4_HUMAN;sp|O94905|ERLN2_HUMAN",690,"E5RHW4","E5RHW4_HUMAN",null,null,"ERLIN2"]
["18.2047","17.3028",1,"16.7832","15.8717",1,{"$nulls":3},"protein targeting to mitochondrion",null,"mitochondrial outer membrane",{"$nulls":3},4,4,4,"15.4","15.4","15.4","35.093",0,"6.7811",28315000,4,"0.0427767",1,"0.950893","0.125479","sp|Q5HYI7|MTX3_HUMAN","sp|Q5HYI7|MTX3_HUMAN",2815,"Q5HYI7","MTX3_HUMAN","Metaxin-3",null,"MTX3"]
["21.6424","20.3107","21.1343","20.3882","19.3302","20.5179",{"$nulls":3},"mRNA processing;regulation of alternative mRNA splicing, via spliceosome;regulation of apoptotic process;RNA splicing","mRNA binding;RNA binding","cytoplasm;nuclear speck;spliceosomal complex","Spliceosome",null,null,34,34,34,"38.7","38.7","38.7","100.18",0,"323.31",4308000000,250,"0.814044",1,"0.950361","1.75872","sp|P49756|RBM25_HUMAN;tr|E9PQU5|E9PQU5_HUMAN;tr|H0YE46|H0YE46_HUMAN;tr|E9PSE8|E9PSE8_HUMAN","sp|P49756|RBM25_HUMAN",1678,"P49756","RBM25_HUMAN","RNA-binding protein 25",null,"RBM25"]
["20.9595","20.5561","19.9084","20.1071","18.7054","19.7605",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;cellular response to reactive oxygen species;cytolysis in other organism;defense response to bacterium;defense response to Gram-negative bacterium;defense response to Gram-positive bacterium;killing of cells of other organism;positive regulation of cell proliferation;positive regulation of reactive oxygen species metabolic process;replicative cell aging",null,"integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},1,1,1,"21.5","21.5","21.5","8.1828",0,"9.7345",38643000,9,"0.847155",1,"0.950347","1.8242","sp|P60602|ROMO1_HUMAN","sp|P60602|ROMO1_HUMAN",1895,"P60602","ROMO1_HUMAN","Reactive oxygen species modulator 1","OS modulator 1","ROMO1"]
["21.5868","20.6258","20.7094","20.7249","19.8117","19.5369",{"$nulls":3},"cell differentiation;multicellular organism development","metal ion binding","focal adhesion;nucleus",{"$nulls":3},5,5,5,"36.3","36.3","36.3","20.954",0,"24.461",195950000,13,"0.939453",1,"0.949471","2.00877","sp|Q16527|CSRP2_HUMAN;tr|F8VW96|F8VW96_HUMAN;tr|F8VQR7|F8VQR7_HUMAN","sp|Q16527|CSRP2_HUMAN;tr|F8VW96|F8VW96_HUMAN;tr|F8VQR7|F8VQR7_HUMAN",2666,"Q16527","CSRP2_HUMAN","Cysteine and glycine-rich protein 2",null,"CSRP2"]
["18.7238","18.1461","17.5379","19.4133","15.5416","16.6047",{"$nulls":3},"mRNA processing;RNA splicing","RNA binding;RNA polymerase core enzyme binding","nuclear matrix;nucleoplasm;spliceosomal complex",{"$nulls":3},7,7,5,"8.5","8.5",7,"140.52",0,"25.661",130920000,19,"0.323604",1,"0.949434","0.788182","sp|Q9UPN6|SCAF8_HUMAN;tr|A0A0A0MT33|A0A0A0MT33_HUMAN","sp|Q9UPN6|SCAF8_HUMAN;tr|A0A0A0MT33|A0A0A0MT33_HUMAN",5172,"Q9UPN6","SCAF8_HUMAN","Protein SCAF8",null,"SCAF8"]
["17.9194","17.2937","18.2374","17.264","16.2707","17.0702",{"$nulls":3},"adaptive immune response;angiogenesis;cell adhesion;cell death;cellular response to vascular endothelial growth factor stimulus;endothelial tube morphogenesis;intracellular signal transduction;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of angiogenesis;positive regulation of blood vessel endothelial cell migration;positive regulation of cell adhesion;positive regulation of CREB transcription factor activity;positive regulation of DNA binding transcription factor activity;positive regulation of DNA biosynthetic process;positive regulation of endothelial cell chemotaxis;positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;positive regulation of endothelial cell migration;positive regulation of endothelial cell proliferation;positive regulation of ERK1 and ERK2 cascade;positive regulation of fibroblast growth factor receptor signaling pathway;positive regulation of histone deacetylase activity;positive regulation of interleukin-2 production;positive regulation of interleukin-8 production;positive regulation of intracellular signal transduction;positive regulation of NF-kappaB transcription factor activity;positive regulation of peptidyl-serine phosphorylation;positive regulation of T cell receptor signaling pathway;positive regulation of transcription from RNA polymerase II promoter;positive regulation of vascular endothelial growth factor receptor signaling pathway;protein autophosphorylation;protein kinase D signaling;protein phosphorylation;sphingolipid biosynthetic process;T cell receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway","ATP binding;metal ion binding;protein kinase activity;protein kinase C activity;protein kinase C binding;protein serine/threonine kinase activity","cytoplasm;cytosol;Golgi apparatus;nucleoplasm;nucleus;plasma membrane","Aldosterone synthesis and secretion;Rap1 signaling pathway",null,null,6,6,6,"12.3","12.3","12.3","96.749",0,"14.331",76230000,11,"1.08385",1,"0.948538","2.30545","sp|Q9BZL6|KPCD2_HUMAN;tr|B4DTS2|B4DTS2_HUMAN;tr|M0R2Z8|M0R2Z8_HUMAN;tr|M0QZC2|M0QZC2_HUMAN;sp|O94806|KPCD3_HUMAN;sp|Q15139|KPCD1_HUMAN;tr|F8WBA3|F8WBA3_HUMAN","sp|Q9BZL6|KPCD2_HUMAN;tr|B4DTS2|B4DTS2_HUMAN",4339,"Q9BZL6","KPCD2_HUMAN","Serine/threonine-protein kinase D2",null,"PRKD2"]
["22.694","21.9778","21.7893","21.5835","20.526","21.5062",{"$nulls":3},"exocytosis;muscle contraction;muscle organ development;muscle system process;negative regulation of insulin receptor signaling pathway;negative regulation of insulin-like growth factor receptor signaling pathway;negative regulation of myotube differentiation;plasma membrane repair;proteasome-mediated ubiquitin-dependent protein catabolic process;protein homooligomerization","phosphatidylserine binding;ubiquitin conjugating enzyme binding;ubiquitin protein ligase activity;zinc ion binding","cytoplasmic vesicle membrane;sarcolemma",{"$nulls":3},17,17,17,"53.2","53.2","53.2","52.73",0,"187.05",1020900000,63,"1.01659",1,"0.948474","2.16588","sp|Q6ZMU5|TRI72_HUMAN","sp|Q6ZMU5|TRI72_HUMAN",3079,"Q6ZMU5","TRI72_HUMAN","Tripartite motif-containing protein 72",null,"TRIM72"]
["19.112","21.4921","19.0777","19.0114","18.9899","18.842",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","cadherin binding","mitochondrion;nucleoplasm",{"$nulls":3},4,4,4,"11.4","11.4","11.4","33.216",0,"7.5468",340010000,9,"0.518687",1,"0.946168","1.18133","sp|Q9NWB6|ARGL1_HUMAN;tr|X6R9F1|X6R9F1_HUMAN","sp|Q9NWB6|ARGL1_HUMAN",4788,"Q9NWB6","ARGL1_HUMAN","Arginine and glutamate-rich protein 1",null,"ARGLU1"]
["23.7872","22.6971","22.7501","23.3104","21.7157","21.3738",{"$nulls":3},"fatty acid beta-oxidation","dodecenoyl-CoA delta-isomerase activity;enoyl-CoA hydratase activity;intramolecular oxidoreductase activity","extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Fatty acid degradation",null,null,8,8,8,"36.1","36.1","36.1","32.816",0,"71.215",880530000,40,"0.610523",1,"0.944855","1.36089","sp|P42126|ECI1_HUMAN;tr|Q96DC0|Q96DC0_HUMAN;tr|H3BS70|H3BS70_HUMAN","sp|P42126|ECI1_HUMAN;tr|Q96DC0|Q96DC0_HUMAN;tr|H3BS70|H3BS70_HUMAN",1541,"P42126","ECI1_HUMAN","Enoyl-CoA delta isomerase 1, mitochondrial",null,"ECI1"]
["18.4646","17.37","18.7884","18.2848","17.0884","16.4154",{"$nulls":3},"apoptotic process;cellular response to DNA damage stimulus;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;hemostasis;learning or memory;locomotory behavior;megakaryocyte development;mRNA localization resulting in posttranscriptional regulation of gene expression;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;platelet alpha granule organization;platelet formation;positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;positive regulation of fat cell differentiation;regulation of cytoplasmic translation;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;mRNA 3'-UTR binding;p53 binding;RNA binding;zinc ion binding","cytoplasm;dendrite;neuronal cell body;nucleolus;nucleoplasm",{"$nulls":3},3,3,3,"11.4","11.4","11.4","40.453",0,"7.0154",54237000,6,"0.609809",1,"0.94482","1.3595","sp|Q96PM9|Z385A_HUMAN;tr|F8VRY0|F8VRY0_HUMAN;tr|H0YI55|H0YI55_HUMAN;tr|H0YIX3|H0YIX3_HUMAN;tr|F8VWV6|F8VWV6_HUMAN;tr|F8VSJ1|F8VSJ1_HUMAN;tr|F8VQ24|F8VQ24_HUMAN","sp|Q96PM9|Z385A_HUMAN;tr|F8VRY0|F8VRY0_HUMAN;tr|H0YI55|H0YI55_HUMAN",3995,"Q96PM9","Z385A_HUMAN","Zinc finger protein 385A",null,"ZNF385A"]
["24.2994","21.2474","23.013","22.7354","20.0655","22.934",{"$nulls":3},"regulation of stem cell differentiation",null,"endosome;membrane;mitochondrion",{"$nulls":3},7,7,7,"37.1","37.1","37.1","27.626",0,"43.31",812120000,48,"0.298702",1,"0.941647","0.735765","sp|Q9NX40|OCAD1_HUMAN;tr|D6RG39|D6RG39_HUMAN;tr|D6RIT9|D6RIT9_HUMAN;tr|D6RDK6|D6RDK6_HUMAN;tr|D6RBN5|D6RBN5_HUMAN;tr|D6R918|D6R918_HUMAN;tr|D6RBC5|D6RBC5_HUMAN;tr|D6RDI5|D6RDI5_HUMAN;tr|D6RA54|D6RA54_HUMAN;tr|D6RC55|D6RC55_HUMAN;tr|D6RF07|D6RF07_HUMAN;tr|D6RI08|D6RI08_HUMAN;tr|D6RDK1|D6RDK1_HUMAN;tr|D6RIV2|D6RIV2_HUMAN;tr|D6R9T5|D6R9T5_HUMAN","sp|Q9NX40|OCAD1_HUMAN;tr|D6RG39|D6RG39_HUMAN;tr|D6RIT9|D6RIT9_HUMAN;tr|D6RDK6|D6RDK6_HUMAN;tr|D6RBN5|D6RBN5_HUMAN",4810,"Q9NX40","OCAD1_HUMAN","OCIA domain-containing protein 1",null,"OCIAD1"]
["20.0115","17.5269","19.5411","19.2823","15.8746","19.1024",{"$nulls":3},"cytoplasmic translation;tRNA methylation;tRNA modification","tRNA (cytosine-2'-O-)-methyltransferase activity;tRNA (guanosine-2'-O-)-methyltransferase activity;tRNA methyltransferase activity","cytoplasm;cytosol",{"$nulls":3},4,4,4,"18.2","18.2","18.2","36.079",0,"17.581",64436000,10,"0.28166",1,"0.940091","0.699458","sp|Q9UET6|TRM7_HUMAN;tr|B7Z4K4|B7Z4K4_HUMAN","sp|Q9UET6|TRM7_HUMAN;tr|B7Z4K4|B7Z4K4_HUMAN",4991,"Q9UET6","TRM7_HUMAN","Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03162}",null,"FTSJ1"]
["19.004","18.3857","18.5582","17.5178","17.599","18.0127",{"$nulls":3},"choline transport;neutrophil degranulation;phosphatidylcholine biosynthetic process;positive regulation of I-kappaB kinase/NF-kappaB signaling;transmembrane transport","choline transmembrane transporter activity;signal transducer activity","extracellular exosome;integral component of membrane;lysosomal membrane;plasma membrane;specific granule membrane","Choline metabolism in cancer",null,null,3,3,3,"3.7","3.7","3.7","80.123","0.00041964","4.4539",84227000,6,"1.76363",1,"0.939486","3.921","sp|Q8IWA5|CTL2_HUMAN;tr|K7ER17|K7ER17_HUMAN;tr|K7EPV6|K7EPV6_HUMAN;tr|K7EMR2|K7EMR2_HUMAN;tr|K7ESF5|K7ESF5_HUMAN","sp|Q8IWA5|CTL2_HUMAN;tr|K7ER17|K7ER17_HUMAN;tr|K7EPV6|K7EPV6_HUMAN",3299,"Q8IWA5","CTL2_HUMAN","Choline transporter-like protein 2",null,"SLC44A2"]
["25.2474","24.2828","24.4525","24.3975","23.3048","23.4672",{"$nulls":3},"actomyosin structure organization;epithelial cell differentiation;negative regulation of ATPase activity","actin binding;cadherin binding involved in cell-cell adhesion;calmodulin binding;microtubule binding","actin cytoskeleton;cell-cell adherens junction;cytosol;dendritic spine;focal adhesion;neuronal cell body;postsynaptic density",{"$nulls":3},15,15,14,"59.6","59.6","56.2","36.413",0,"281.27",2961000000,99,"0.972079",1,"0.937721","2.07487","sp|Q15417|CNN3_HUMAN;tr|E9PDU6|E9PDU6_HUMAN","sp|Q15417|CNN3_HUMAN;tr|E9PDU6|E9PDU6_HUMAN",2598,"Q15417","CNN3_HUMAN","Calponin-3",null,"CNN3"]
["16.9435","17.9737","17.2391","16.5441","16.5235","16.2813",{"$nulls":3},"dendrite morphogenesis;negative regulation of phosphatase activity;regulation of Rho protein signal transduction;synapse assembly","cytoskeletal protein binding;Rac guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity","cell junction;cytoskeleton;cytosol;dendrite;dendritic spine;extrinsic component of cytoplasmic side of plasma membrane;filopodium",{"$nulls":3},18,18,18,"22.4","22.4","22.4","118.63",0,"97.638",585020000,65,"1.37531",1,"0.935823","2.94594","sp|Q9Y4F1|FARP1_HUMAN;tr|C9JME2|C9JME2_HUMAN;tr|M0QYB0|M0QYB0_HUMAN;tr|M0QXT1|M0QXT1_HUMAN;tr|M0R262|M0R262_HUMAN;tr|H0Y783|H0Y783_HUMAN","sp|Q9Y4F1|FARP1_HUMAN;tr|C9JME2|C9JME2_HUMAN",5325,"Q9Y4F1","FARP1_HUMAN","FERM, ARHGEF and pleckstrin domain-containing protein 1",null,"FARP1"]
["24.7207","24.1501","23.9174","23.7546","23.2492","22.9788",{"$nulls":3},"epithelial cell differentiation;negative regulation of apoptotic process;negative regulation of interleukin-8 secretion;negative regulation of NF-kappaB transcription factor activity;Notch signaling pathway;regulation of transcription from RNA polymerase II promoter;signal transduction","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;identical protein binding;NF-kappaB binding;phospholipase inhibitor activity","cell surface;cytoplasm;extracellular exosome;nuclear membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;vesicle membrane",{"$nulls":3},24,24,24,"70.8","70.8","70.8","35.882",0,"323.31",3366900000,136,"1.32801",1,"0.935214","2.83745","sp|P09525|ANXA4_HUMAN;tr|Q6P452|Q6P452_HUMAN","sp|P09525|ANXA4_HUMAN;tr|Q6P452|Q6P452_HUMAN",992,"P09525","ANXA4_HUMAN","Annexin A4",null,"ANXA4"]
["20.7548","18.1914","19.3689","18.5722","18.7626","18.1755",{"$nulls":4},"microtubule binding;microtubule plus-end binding","cytoplasmic microtubule;microtubule associated complex;microtubule plus-end",{"$nulls":3},15,14,14,"20.9","19.8","19.8","115.84",0,"52.961",1681400000,44,"0.543013",1,"0.93497","1.22906","sp|Q9UDT6|CLIP2_HUMAN;tr|H7C4L6|H7C4L6_HUMAN","sp|Q9UDT6|CLIP2_HUMAN",4982,"Q9UDT6","CLIP2_HUMAN","CAP-Gly domain-containing linker protein 2",null,"CLIP2"]
["22.4097","20.9178","21.4539","20.9332","20.3654","20.6781",{"$nulls":3},"glycosphingolipid metabolic process;intracellular protein transport;negative regulation of chaperone-mediated autophagy;neutrophil degranulation;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of chaperone-mediated autophagy;regulation of protein stability","carboxypeptidase activity;enzyme activator activity;exo-alpha-sialidase activity;serine-type carboxypeptidase activity","azurophil granule lumen;endoplasmic reticulum;extracellular exosome;extracellular region;intracellular membrane-bounded organelle;lysosomal lumen;lysosome;membrane;nucleoplasm","Lysosome;Renin-angiotensin system",null,null,5,5,5,"12.7","12.7","12.7","54.465",0,"24.646",367970000,19,"0.937768",1,"0.934916","2.00537","sp|P10619|PPGB_HUMAN;tr|X6R5C5|X6R5C5_HUMAN;tr|X6R8A1|X6R8A1_HUMAN;tr|Q5JZH0|Q5JZH0_HUMAN","sp|P10619|PPGB_HUMAN;tr|X6R5C5|X6R5C5_HUMAN;tr|X6R8A1|X6R8A1_HUMAN",1023,"P10619","PPGB_HUMAN","Lysosomal protective protein",null,"CTSA"]
["21.0122","21.4881","21.3058","18.9895","21.4032","20.6109",{"$nulls":3},"arginine catabolic process;citrulline metabolic process;negative regulation of cell proliferation;negative regulation of cellular response to hypoxia;negative regulation of vascular permeability;nitric oxide mediated signal transduction;positive regulation of angiogenesis;positive regulation of nitric oxide biosynthetic process;regulation of nitric-oxide synthase activity;regulation of systemic arterial blood pressure","amino acid binding;catalytic activity;dimethylargininase activity;metal ion binding","cytosol;extracellular exosome;mitochondrion",{"$nulls":3},9,9,8,"36.5","36.5","33.7","31.121",0,"34.175",526240000,27,"0.57457",1,"0.934181","1.29077","sp|O94760|DDAH1_HUMAN;tr|B4DYP1|B4DYP1_HUMAN","sp|O94760|DDAH1_HUMAN;tr|B4DYP1|B4DYP1_HUMAN",670,"O94760","DDAH1_HUMAN","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1","DAH-1;imethylarginine dimethylaminohydrolase 1","DDAH1"]
["21.5031","20.4836","20.3994","20.3612","19.2465","19.9765",{"$nulls":3},"apoptotic process;apoptotic signaling pathway;regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding","centrosome;cytosol;intracellular membrane-bounded organelle;nuclear chromatin;nucleoplasm",{"$nulls":3},14,14,14,"40.7","40.7","40.7","44.155",0,"174.69",1529200000,130,"0.903362",1,"0.933926","1.9362","sp|Q92785|REQU_HUMAN;tr|J3KMZ8|J3KMZ8_HUMAN;tr|E9PN04|E9PN04_HUMAN","sp|Q92785|REQU_HUMAN;tr|J3KMZ8|J3KMZ8_HUMAN",3713,"Q92785","REQU_HUMAN","Zinc finger protein ubi-d4",null,"DPF2"]
["22.6299","22.0386","21.0106","20.0717","21.5432","21.2665",{"$nulls":3},"cholesterol biosynthetic process;sterol biosynthetic process","chromo shadow domain binding;delta14-sterol reductase activity;DNA binding;lamin binding;oxidoreductase activity, acting on the CH-CH group of donors;RNA binding","integral component of membrane;integral component of nuclear inner membrane;membrane;nuclear envelope;nuclear membrane",{"$nulls":3},12,12,12,19,19,19,"70.702",0,"97.772",1555400000,84,"0.643954",1,"0.932563","1.42601","sp|Q14739|LBR_HUMAN;tr|C9JXK0|C9JXK0_HUMAN;tr|C9JES9|C9JES9_HUMAN","sp|Q14739|LBR_HUMAN;tr|C9JXK0|C9JXK0_HUMAN",2503,"Q14739","LBR_HUMAN","Lamin-B receptor",null,"LBR"]
["18.7822","17.4687","16.8234","17.4976","16.5222","16.2581",{"$nulls":3},"anion homeostasis;arginine biosynthetic process;carbamoyl phosphate biosynthetic process;cellular response to ammonia;cellular response to cAMP;cellular response to fibroblast growth factor stimulus;cellular response to glucagon stimulus;cellular response to oleic acid;citrulline biosynthetic process;'de novo' pyrimidine nucleobase biosynthetic process;glutamine metabolic process;hepatocyte differentiation;homocysteine metabolic process;midgut development;nitric oxide metabolic process;response to amine;response to amino acid;response to dexamethasone;response to drug;response to food;response to growth hormone;response to lipopolysaccharide;response to starvation;response to toxic substance;response to zinc ion;triglyceride catabolic process;urea cycle;vasodilation","ATP binding;calcium ion binding;carbamoyl-phosphate synthase (ammonia) activity;carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;endopeptidase activity;glutamate binding;modified amino acid binding;phospholipid binding;protein complex binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrial nucleoid;nucleolus;protein complex","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Nitrogen metabolism",null,null,14,12,12,"12.5","11.5","11.5","164.94",0,"28.016",161600000,18,"0.606812",1,"0.93217","1.35366","sp|P31327|CPSM_HUMAN;tr|Q5R211|Q5R211_HUMAN;tr|C9JTA4|C9JTA4_HUMAN;tr|E7EWJ3|E7EWJ3_HUMAN","sp|P31327|CPSM_HUMAN",1403,"P31327","CPSM_HUMAN","Carbamoyl-phosphate synthase [ammonia], mitochondrial",null,"CPS1"]
["22.9781","21.4028","22.4441","21.8639","20.5291","21.6394",{"$nulls":3},"aromatic compound catabolic process;epoxide metabolic process;response to organic cyclic compound;response to toxic substance;xenobiotic metabolic process","cis-stilbene-oxide hydrolase activity;epoxide hydrolase activity","endoplasmic reticulum membrane;integral component of membrane;organelle membrane","Bile secretion;Chemical carcinogenesis;Metabolism of xenobiotics by cytochrome P450",null,null,18,18,18,"41.1","41.1","41.1","52.948",0,"83.086",897960000,57,"0.682828",1,"0.930883","1.50174","sp|P07099|HYEP_HUMAN;tr|B1AQP8|B1AQP8_HUMAN;tr|B1AQP9|B1AQP9_HUMAN","sp|P07099|HYEP_HUMAN",927,"P07099","HYEP_HUMAN","Epoxide hydrolase 1",null,"EPHX1"]
["17.6795","15.1122","15.5215","17.0294","13.6582","14.8395",{"$nulls":3},"chondroitin sulfate biosynthetic process","glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;metal ion binding;N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity","cytosol;Golgi cisterna membrane;Golgi membrane;integral component of membrane;mitochondrial matrix","Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate;Metabolic pathways",null,null,2,2,2,"3.5","3.5","3.5","85.466","0.00081583","3.8966",24208000,1,"0.296931",1,"0.928692","0.732009","sp|Q8IZ52|CHSS2_HUMAN","sp|Q8IZ52|CHSS2_HUMAN",3349,"Q8IZ52","CHSS2_HUMAN","Chondroitin sulfate synthase 2",null,"CHPF"]
["27.9857","26.6486","27.0787","26.535","25.954","26.4381",{"$nulls":3},"aerobic respiration;gluconeogenesis;internal protein amino acid acetylation;malate metabolic process;NADH metabolic process;oxaloacetate metabolic process;tricarboxylic acid cycle","L-malate dehydrogenase activity;malate dehydrogenase (NADP+) activity;protein self-association;RNA binding","extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;myelin sheath;nucleus","Carbon metabolism;Citrate cycle (TCA cycle);Cysteine and methionine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Pyruvate metabolism",null,null,16,16,16,"61.5","61.5","61.5","35.503",0,"323.31",24614000000,415,"1.0059",1,"0.928597","2.14394","sp|P40926|MDHM_HUMAN;tr|G3XAL0|G3XAL0_HUMAN","sp|P40926|MDHM_HUMAN;tr|G3XAL0|G3XAL0_HUMAN",1524,"P40926","MDHM_HUMAN","Malate dehydrogenase, mitochondrial",null,"MDH2"]
["17.9508","16.5265","17.6889","16.2939","15.8012","17.2922",{"$nulls":3},"calcium ion export;calcium ion import across plasma membrane;calcium ion transmembrane import into cytosol;calcium ion transmembrane transport;cellular calcium ion homeostasis;cellular response to epinephrine stimulus;flagellated sperm motility;hippocampus development;ion transmembrane transport;negative regulation of adrenergic receptor signaling pathway involved in heart process;negative regulation of arginine catabolic process;negative regulation of calcineurin-NFAT signaling cascade;negative regulation of cardiac muscle hypertrophy in response to stress;negative regulation of citrulline biosynthetic process;negative regulation of nitric oxide biosynthetic process;negative regulation of nitric oxide mediated signal transduction;negative regulation of nitric-oxide synthase activity;negative regulation of peptidyl-cysteine S-nitrosylation;negative regulation of the force of heart contraction;neural retina development;positive regulation of cAMP-dependent protein kinase activity;positive regulation of peptidyl-serine phosphorylation;regulation of cardiac conduction;regulation of cell cycle G1/S phase transition;regulation of sodium ion transmembrane transport;regulation of transcription from RNA polymerase II promoter;response to hydrostatic pressure;spermatogenesis","ATP binding;calcium-transporting ATPase activity;calmodulin binding;metal ion binding;nitric-oxide synthase binding;nitric-oxide synthase inhibitor activity;PDZ domain binding;protein kinase binding;protein phosphatase 2B binding;scaffold protein binding","basolateral plasma membrane;caveola;integral component of plasma membrane;intracellular membrane-bounded organelle;membrane;neuron projection;plasma membrane;protein complex;sperm flagellum;sperm principal piece;T-tubule;Z disc","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Calcium signaling pathway;cAMP signaling pathway;cGMP-PKG signaling pathway;Pancreatic secretion;Salivary secretion",null,null,10,4,4,12,"5.2","5.2","137.92",0,"21.639",126670000,20,"0.679314",1,"0.9263","1.49489","sp|P23634|AT2B4_HUMAN","sp|P23634|AT2B4_HUMAN",1272,"P23634","AT2B4_HUMAN","Plasma membrane calcium-transporting ATPase 4 {ECO:0000305}","MCA4 {ECO:0000303|PubMed:1531651, ECO:0000312|EMBL:AAA50819.1}","ATP2B4"]
["19.3198","16.3949","17.0793","18.112","15.3805","16.5305",{"$nulls":3},"blastocyst growth;cell division;chromosome organization;intestinal epithelial structure maintenance;mitotic cell cycle;mitotic DNA damage checkpoint;mitotic DNA replication checkpoint;negative regulation of apoptotic process;nuclear DNA replication;ovarian follicle development;preantral ovarian follicle growth;replication fork protection;transcription-coupled nucleotide-excision repair","nucleic acid binding;zinc ion binding","chromosome;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"17.2","17.2","17.2","41.998",0,"7.4249",29001000,9,"0.319073",1,"0.923712","0.778696","sp|Q96NB3|ZN830_HUMAN","sp|Q96NB3|ZN830_HUMAN",3983,"Q96NB3","ZN830_HUMAN","Zinc finger protein 830 {ECO:0000312|HGNC:HGNC:28291}",null,"ZNF830"]
["24.128","22.6807","23.0069","22.9651","22.2651","21.8145",{"$nulls":3},"cellular response to thyroid hormone stimulus;collagen catabolic process;decidualization;epithelial cell differentiation;neutrophil degranulation;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of apoptotic process;regulation of catalytic activity;toll-like receptor signaling pathway;viral entry into host cell","collagen binding;cysteine-type endopeptidase activity;cysteine-type peptidase activity;peptidase activity;proteoglycan binding;serine-type endopeptidase activity","endolysosome lumen;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;intracellular;intracellular membrane-bounded organelle;lysosome;melanosome;mitochondrion;nucleolus;perinuclear region of cytoplasm","Antigen processing and presentation;Apoptosis;Autophagy - animal;Lysosome;NOD-like receptor signaling pathway;Renin secretion",null,null,9,9,9,"37.5","37.5","37.5","37.821",0,"186.37",1251600000,57,"0.771319",1,"0.92362","1.67468","sp|P07858|CATB_HUMAN;tr|E9PKQ7|E9PKQ7_HUMAN;tr|E9PNL5|E9PNL5_HUMAN;tr|E9PHZ5|E9PHZ5_HUMAN;tr|E9PLY3|E9PLY3_HUMAN;tr|E9PSG5|E9PSG5_HUMAN;tr|E9PQM1|E9PQM1_HUMAN;tr|R4GMQ5|R4GMQ5_HUMAN;tr|E9PR54|E9PR54_HUMAN;tr|E9PJ67|E9PJ67_HUMAN;tr|E9PCB3|E9PCB3_HUMAN;tr|E9PS78|E9PS78_HUMAN","sp|P07858|CATB_HUMAN",945,"P07858","CATB_HUMAN","Cathepsin B",null,"CTSB"]
["25.6085","24.3653","25.0552","24.7253","22.6748","24.8677",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;oxidative phosphorylation;protein processing involved in protein targeting to mitochondrion","metalloendopeptidase activity;protein complex binding;zinc ion binding","extracellular exosome;mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrial respiratory chain complex IV;mitochondrion;myelin sheath;nucleoplasm","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,22,22,22,"71.5","71.5","71.5","48.442",0,"323.31",6393400000,341,"0.507074",1,"0.920399","1.15849","sp|P22695|QCR2_HUMAN;tr|H3BRG4|H3BRG4_HUMAN;tr|H3BSJ9|H3BSJ9_HUMAN;tr|H3BP04|H3BP04_HUMAN;tr|H3BUE4|H3BUE4_HUMAN;tr|H3BUI9|H3BUI9_HUMAN;tr|A0A087WVZ4|A0A087WVZ4_HUMAN","sp|P22695|QCR2_HUMAN;tr|H3BRG4|H3BRG4_HUMAN;tr|H3BSJ9|H3BSJ9_HUMAN",1252,"P22695","QCR2_HUMAN","Cytochrome b-c1 complex subunit 2, mitochondrial",null,"UQCRC2"]
["19.9334","18.8598","19.5997","19.419","18.1976","18.017",{"$nulls":3},"chromatin silencing;mitochondrion organization;negative regulation of cardiac muscle cell apoptotic process;negative regulation of reactive oxygen species metabolic process;peptidyl-lysine demalonylation;peptidyl-lysine desuccinylation;protein ADP-ribosylation;protein deacetylation;protein deglutarylation;protein demalonylation;protein desuccinylation;regulation of ketone biosynthetic process;response to nutrient levels","NAD+ ADP-ribosyltransferase activity;NAD+ binding;NAD-dependent protein deacetylase activity;protein-glutaryllysine deglutarylase activity;protein-malonyllysine demalonylase activity;protein-succinyllysine desuccinylase activity;zinc ion binding","cytosol;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;nucleus",{"$nulls":3},4,4,4,"20.6","20.6","20.6","33.881",0,"13.611",112760000,14,"0.78155",1,"0.919778","1.69476","sp|Q9NXA8|SIR5_HUMAN","sp|Q9NXA8|SIR5_HUMAN",4822,"Q9NXA8","SIR5_HUMAN","NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}",null,"SIRT5"]
["22.5171","18.7319","20.9037","20.6841","18.4554","20.2544",{"$nulls":3},"exocytosis;negative regulation of neuron apoptotic process;neurotransmitter secretion;neutrophil degranulation;regulated exocytosis;synaptic vesicle exocytosis","ATP-dependent protein binding","azurophil granule membrane;clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;extracellular exosome;lysosomal membrane;melanosome;membrane;mitochondrion;plasma membrane;specific granule membrane;synaptic vesicle;terminal bouton","Protein processing in endoplasmic reticulum",null,null,3,3,3,"36.9","36.9","36.9","22.149",0,"27.988",115190000,16,"0.287488",1,"0.919629","0.711916","sp|Q9H3Z4|DNJC5_HUMAN","sp|Q9H3Z4|DNJC5_HUMAN",4454,"Q9H3Z4","DNJC5_HUMAN","DnaJ homolog subfamily C member 5 {ECO:0000305}",null,"DNAJC5"]
["19.6944","17.3642","19.7002","18.0654","17.3656","18.5717",{"$nulls":3},"acylglycerol catabolic process;adult walking behavior;glycerophospholipid catabolic process;monoacylglycerol catabolic process;phosphatidylserine catabolic process;protein depalmitoylation;response to auditory stimulus","acylglycerol lipase activity;lysophospholipase activity;palmitoyl-(protein) hydrolase activity","AMPA glutamate receptor complex;dendrite cytoplasm;integral component of membrane;plasma membrane",{"$nulls":3},8,8,8,"27.9","27.9","27.9","45.096",0,"17.937",159110000,18,"0.466028",1,"0.91866","1.07736","sp|Q8N2K0|ABD12_HUMAN;tr|I3L294|I3L294_HUMAN;tr|Q5T712|Q5T712_HUMAN;tr|I3L440|I3L440_HUMAN;tr|I3L1V0|I3L1V0_HUMAN;tr|I3L380|I3L380_HUMAN","sp|Q8N2K0|ABD12_HUMAN;tr|I3L294|I3L294_HUMAN;tr|Q5T712|Q5T712_HUMAN",3383,"Q8N2K0","ABD12_HUMAN","Monoacylglycerol lipase ABHD12 {ECO:0000305}",null,"ABHD12"]
["18.3394",1,"17.9879",1,"16.1102","17.4631",{"$nulls":3},"cell division;chromosome segregation",null,"cytosol;MIS12/MIND type complex;nucleus",{"$nulls":3},1,1,1,"8.1","8.1","8.1","32.219","0.00081649","3.9055",17984000,3,"0.0401008",1,"0.918022","0.117941","tr|Q5JW54|Q5JW54_HUMAN;sp|Q9H410|DSN1_HUMAN","tr|Q5JW54|Q5JW54_HUMAN;sp|Q9H410|DSN1_HUMAN",4455,"Q5JW54","Q5JW54_HUMAN",null,null,"DSN1"]
["20.718","19.3077","20.3447","19.1425","18.5567","19.9286",{"$nulls":3},"actin filament organization;cell adhesion",{"$nulls":5},5,5,5,"30.5","30.5","30.5","24.987",0,"11.169",117630000,12,"0.721613",1,"0.914232","1.57739","tr|H0YB51|H0YB51_HUMAN;sp|O60504|VINEX_HUMAN;tr|E5RJP2|E5RJP2_HUMAN;tr|H0YAZ3|H0YAZ3_HUMAN","tr|H0YB51|H0YB51_HUMAN;sp|O60504|VINEX_HUMAN;tr|E5RJP2|E5RJP2_HUMAN;tr|H0YAZ3|H0YAZ3_HUMAN",500,"H0YB51","H0YB51_HUMAN",null,null,"SORBS3"]
["21.393","19.6696","19.3634","19.1561","19.3041","19.2358",{"$nulls":5},"integral component of membrane",{"$nulls":3},6,6,6,"25.8","25.8","25.8","41.767",0,"39.077",153590000,17,"0.649751",1,"0.910049","1.4373","tr|A0A0C4DGH0|A0A0C4DGH0_HUMAN;sp|Q5ZPR3|CD276_HUMAN;tr|H0YL10|H0YL10_HUMAN;tr|H0YK40|H0YK40_HUMAN;tr|H0YK59|H0YK59_HUMAN;tr|H0YLT8|H0YLT8_HUMAN;tr|H0YN85|H0YN85_HUMAN;tr|H0YN29|H0YN29_HUMAN","tr|A0A0C4DGH0|A0A0C4DGH0_HUMAN;sp|Q5ZPR3|CD276_HUMAN;tr|H0YL10|H0YL10_HUMAN;tr|H0YK40|H0YK40_HUMAN;tr|H0YK59|H0YK59_HUMAN",2918,"A0A0C4DGH0","A0A0C4DGH0_HUMAN",null,null,"CD276"]
["21.2945","19.8202","20.4554","19.8885","18.5831","20.3793",{"$nulls":3},"aspartate transport;gluconeogenesis;L-glutamate transport;malate-aspartate shuttle;response to calcium ion","acidic amino acid transmembrane transporter activity;calcium ion binding;L-aspartate transmembrane transporter activity;L-glutamate transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane;mitochondrion;myelin sheath",{"$nulls":3},20,20,15,"34.1","34.1","26.4","74.761",0,"46.861",617880000,77,"0.590938",1,"0.906413","1.32271","sp|O75746|CMC1_HUMAN;tr|F8W9J0|F8W9J0_HUMAN;tr|H0YFB2|H0YFB2_HUMAN;tr|B4DGK6|B4DGK6_HUMAN","sp|O75746|CMC1_HUMAN",629,"O75746","CMC1_HUMAN","Calcium-binding mitochondrial carrier protein Aralar1",null,"SLC25A12"]
["18.2997","17.9565","18.126","17.0152","17.2265","17.4214",{"$nulls":4},"nucleic acid binding","cytosol;nucleoplasm;plasma membrane",{"$nulls":3},7,7,7,"9.1","9.1","9.1","145.44",0,"38.392",144490000,24,"2.38493",1,"0.906387","5.90282","tr|S4R3H4|S4R3H4_HUMAN;tr|E7EQT4|E7EQT4_HUMAN;sp|Q9UKV3|ACINU_HUMAN;tr|G3V3B0|G3V3B0_HUMAN;tr|G3V3T3|G3V3T3_HUMAN","tr|S4R3H4|S4R3H4_HUMAN;tr|E7EQT4|E7EQT4_HUMAN;sp|Q9UKV3|ACINU_HUMAN",5625,"S4R3H4","S4R3H4_HUMAN",null,null,"ACIN1"]
["20.0647","18.6105","17.8476","18.583","17.867","17.3608",{"$nulls":3},"base-excision repair;base-excision repair, DNA ligation;cerebellum morphogenesis;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;hippocampus development;negative regulation of protection from non-homologous end joining at telomere;negative regulation of protein ADP-ribosylation;nucleotide-excision repair, DNA gap filling;positive regulation of DNA ligase activity;positive regulation of single strand break repair;replication-born double-strand break repair via sister chromatid exchange;response to drug;response to hydroperoxide;response to hypoxia;response to organic substance;single strand break repair;telomeric DNA-containing double minutes formation;transcription-coupled nucleotide-excision repair;voluntary musculoskeletal movement","3' overhang single-stranded DNA endodeoxyribonuclease activity;DNA ligase activity;enzyme binding;oxidized DNA binding","ERCC4-ERCC1 complex;nuclear chromatin;nuclear chromosome, telomeric region;nucleolus;nucleoplasm;nucleus","Base excision repair",null,null,8,8,1,"19.3","19.3",3,"69.476",0,"34.227",271000000,37,"0.538649",1,"0.904027","1.22051","sp|P18887|XRCC1_HUMAN;tr|M0R0D2|M0R0D2_HUMAN","sp|P18887|XRCC1_HUMAN;tr|M0R0D2|M0R0D2_HUMAN",1187,"P18887","XRCC1_HUMAN","DNA repair protein XRCC1",null,"XRCC1"]
["23.7429","23.1543","23.4386","22.6775","21.9231","23.0251",{"$nulls":3},"cellular protein metabolic process;neutrophil degranulation;post-translational protein modification","RNA binding","azurophil granule membrane;cytoplasmic ribonucleoprotein granule;cytoskeleton;cytosol;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular exosome;extracellular matrix;integral component of membrane;lamellar body;lipid droplet;membrane;nuclear speck;perinuclear region of cytoplasm;plasma membrane;rough endoplasmic reticulum;specific granule membrane","Protein processing in endoplasmic reticulum",null,null,36,36,36,60,60,60,"66.022",0,"323.31",16399000000,640,"1.15748",1,"0.903369","2.46141","sp|Q07065|CKAP4_HUMAN","sp|Q07065|CKAP4_HUMAN",2213,"Q07065","CKAP4_HUMAN","Cytoskeleton-associated protein 4",null,"CKAP4"]
["21.4455","20.6294","21.0202","20.5695","18.8966","20.9255",{"$nulls":3},"calcium-mediated signaling;glucose homeostasis;mitochondrial calcium ion transmembrane transport;mitochondrial calcium uptake;positive regulation of insulin secretion;positive regulation of mitochondrial calcium ion concentration;protein complex oligomerization","calcium channel activity;identical protein binding;uniporter activity","calcium channel complex;integral component of mitochondrial inner membrane;mitochondrial inner membrane;mitochondrion;uniplex complex","Calcium signaling pathway;Cellular senescence;NOD-like receptor signaling pathway",null,null,8,8,8,"26.8","26.8","26.8","39.866",0,"24.983",391510000,24,"0.604053",1,"0.901183","1.34828","sp|Q8NE86|MCU_HUMAN;tr|S4R468|S4R468_HUMAN","sp|Q8NE86|MCU_HUMAN;tr|S4R468|S4R468_HUMAN",3488,"Q8NE86","MCU_HUMAN","Calcium uniporter protein, mitochondrial {ECO:0000303|PubMed:21685886}","sMCU {ECO:0000303|PubMed:27135929}","MCU"]
["23.3531","21.5672","21.9483","22.1217","20.2688","21.7762",{"$nulls":4},"NAD+ kinase activity","intracellular membrane-bounded organelle;mitochondrion",{"$nulls":3},16,16,16,"58.1","58.1","58.1","43.796",0,"184.09",2702100000,130,"0.500312",1,"0.900639","1.14517","tr|E9PC15|E9PC15_HUMAN;sp|Q53H12|AGK_HUMAN;tr|A0A0G2JLG5|A0A0G2JLG5_HUMAN;tr|E9PG39|E9PG39_HUMAN;tr|A0A0G2JLD0|A0A0G2JLD0_HUMAN","tr|E9PC15|E9PC15_HUMAN;sp|Q53H12|AGK_HUMAN;tr|A0A0G2JLG5|A0A0G2JLG5_HUMAN;tr|E9PG39|E9PG39_HUMAN",2781,"E9PC15","E9PC15_HUMAN",null,null,"AGK"]
["22.4629","22.3641","20.9278","21.2236","20.8699","20.9644",{"$nulls":3},"cardiovascular system development;fatty acid metabolic process;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;mitochondrion morphogenesis;multicellular organism aging;multicellular organism growth;muscle contraction;reproductive system development","electron transfer activity;NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex I","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,5,5,5,54,54,54,"13.711",0,"57.359",246790000,19,"0.820966",1,"0.898947","1.77238","sp|O75380|NDUS6_HUMAN;tr|D6RBT3|D6RBT3_HUMAN","sp|O75380|NDUS6_HUMAN;tr|D6RBT3|D6RBT3_HUMAN",577,"O75380","NDUS6_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial",null,"NDUFS6"]
["23.4846","21.0135","22.2997","22.111","20.0212","21.9716",{"$nulls":3},"transmembrane transport",null,"integral component of membrane",{"$nulls":3},11,11,11,"41.2","41.2","41.2","33.281",0,"169.64",1034400000,103,"0.384904",1,"0.897987","0.91451","tr|E9PJH7|E9PJH7_HUMAN;sp|Q9H936|GHC1_HUMAN;tr|A0A0D9SFE1|A0A0D9SFE1_HUMAN;tr|A0A0D9SEI9|A0A0D9SEI9_HUMAN;tr|K4DIB8|K4DIB8_HUMAN;tr|K4DIA8|K4DIA8_HUMAN;tr|E9PS95|E9PS95_HUMAN;tr|K4DIB6|K4DIB6_HUMAN;tr|K4DIB3|K4DIB3_HUMAN;sp|Q9H1K4|GHC2_HUMAN;tr|A0A0D9SFA8|A0A0D9SFA8_HUMAN;tr|K4DIB0|K4DIB0_HUMAN;tr|K4DIA2|K4DIA2_HUMAN;tr|A0A0D9SG84|A0A0D9SG84_HUMAN;tr|E9PI74|E9PI74_HUMAN;tr|E9PQ36|E9PQ36_HUMAN;tr|E9PJY0|E9PJY0_HUMAN;tr|A0A0A6YYN8|A0A0A6YYN8_HUMAN","tr|E9PJH7|E9PJH7_HUMAN;sp|Q9H936|GHC1_HUMAN;tr|A0A0D9SFE1|A0A0D9SFE1_HUMAN;tr|A0A0D9SEI9|A0A0D9SEI9_HUMAN;tr|K4DIB8|K4DIB8_HUMAN;tr|K4DIA8|K4DIA8_HUMAN",4530,"E9PJH7","E9PJH7_HUMAN",null,null,"SLC25A22"]
["21.0424","19.9161","19.4279","20.0548","18.7194","18.9202",{"$nulls":3},"mRNA splicing, via spliceosome","C2H2 zinc finger domain binding;protein N-terminus binding;RNA binding","Cajal body;catalytic step 2 spliceosome;nuclear speck;nucleoplasm",{"$nulls":3},40,40,40,"21.7","21.7","21.7","299.61",0,"187.38",2347600000,240,"0.639007",1,"0.897315","1.41638","sp|Q9UQ35|SRRM2_HUMAN;tr|I3L4D8|I3L4D8_HUMAN;tr|I3L182|I3L182_HUMAN;tr|I3L1I8|I3L1I8_HUMAN;tr|A0A087X1W1|A0A087X1W1_HUMAN;tr|I3L1C0|I3L1C0_HUMAN;tr|I3L4U6|I3L4U6_HUMAN;tr|I3L3Q8|I3L3Q8_HUMAN","sp|Q9UQ35|SRRM2_HUMAN",5186,"Q9UQ35","SRRM2_HUMAN","Serine/arginine repetitive matrix protein 2",null,"SRRM2"]
["22.3296","19.1522","20.4994","20.3337","18.7454","20.2116",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular signal transduction;protein phosphorylation;transcription initiation from RNA polymerase II promoter","ATP binding;protein homodimerization activity;protein serine/threonine kinase activity","cell cortex;cytosol;endomembrane system;lamellipodium;membrane;nucleoplasm",{"$nulls":3},7,7,7,"22.1","22.1","22.1","59.844",0,"36.816",229420000,26,"0.354327",1,"0.896833","0.851929","sp|Q9UHY1|NRBP_HUMAN;tr|F8W6G1|F8W6G1_HUMAN;tr|C9JHZ6|C9JHZ6_HUMAN;tr|C9JDW7|C9JDW7_HUMAN","sp|Q9UHY1|NRBP_HUMAN;tr|F8W6G1|F8W6G1_HUMAN",5037,"Q9UHY1","NRBP_HUMAN","Nuclear receptor-binding protein",null,"NRBP1"]
["19.2536",1,"18.0995","16.1174",1,"18.5486",{"$nulls":3},"DNA-templated transcription, initiation;histone H3 acetylation;positive regulation of DNA binding transcription factor activity;regulation of signal transduction by p53 class mediator;RNA polymerase II transcriptional preinitiation complex assembly;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","DNA binding;protein heterodimerization activity;RNA polymerase II activating transcription factor binding;TBP-class protein binding;transcription coactivator activity;transcription factor binding","nucleoplasm;nucleus;PCAF complex;SAGA complex;STAGA complex;transcription factor TFIID complex;transcription factor TFTC complex","Basal transcription factors",null,null,3,3,3,18,18,18,"17.924",0,"7.3418",101220000,8,"0.0376933",1,"0.895683","0.111128","sp|Q16514|TAF12_HUMAN","sp|Q16514|TAF12_HUMAN",2665,"Q16514","TAF12_HUMAN","Transcription initiation factor TFIID subunit 12",null,"TAF12"]
["21.4133","21.5068",1,"19.5658","20.6773",1,{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding","catalytic step 2 spliceosome;mitochondrion;nuclear speck;nucleoplasm;nucleus;spliceosomal complex","Spliceosome",null,null,2,2,2,"15.3","15.3","15.3","26.624",0,"10.752",103410000,8,"0.0322255",1,"0.892337","0.0955356","sp|Q9P013|CWC15_HUMAN","sp|Q9P013|CWC15_HUMAN",4895,"Q9P013","CWC15_HUMAN","Spliceosome-associated protein CWC15 homolog",null,"CWC15"]
["17.5468","15.5388","15.8201","15.6048","15.1112","15.5147",{"$nulls":3},"DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;gene silencing by RNA;nuclear-transcribed mRNA poly(A) tail shortening;regulation of transcription, DNA-templated;regulation of translation;transcription, DNA-templated",null,"CCR4-NOT complex;cytosol;membrane;nucleus","RNA degradation",null,null,3,3,3,5,5,5,"82.309",0,"6.767",55368000,8,"0.620677",1,"0.89164","1.38068","sp|Q9H9A5|CNO10_HUMAN;tr|H7C0K1|H7C0K1_HUMAN;tr|H7C1X9|H7C1X9_HUMAN;tr|E9PCN5|E9PCN5_HUMAN","sp|Q9H9A5|CNO10_HUMAN;tr|H7C0K1|H7C0K1_HUMAN",4537,"Q9H9A5","CNO10_HUMAN","CCR4-NOT transcription complex subunit 10",null,"CNOT10"]
["23.7273","22.5253","22.2727","22.9148","20.9647","21.9715",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;actin filament network formation;actin filament organization;focal adhesion assembly;negative regulation of cellular component movement;platelet degranulation;platelet formation;platelet morphogenesis;regulation of apoptotic process","actin filament binding;calcium ion binding;double-stranded RNA binding;integrin binding;ion channel binding;ligand-dependent nuclear receptor transcription coactivator activity;protein homodimerization activity;vinculin binding","brush border;cell projection;cell-cell junction;cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;fascia adherens;focal adhesion;intracellular;plasma membrane;platelet alpha granule lumen;pseudopodium;ruffle;stress fiber;Z disc","Adherens junction;Amoebiasis;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Systemic lupus erythematosus;Tight junction;Viral carcinogenesis",null,null,48,31,31,"66.9","48.3","48.3","103.06",0,"323.31",3623800000,192,"0.547641",1,"0.891453","1.23812","sp|P12814|ACTN1_HUMAN;tr|H9KV75|H9KV75_HUMAN;tr|G3V2W4|G3V2W4_HUMAN;tr|G3V2N5|G3V2N5_HUMAN;tr|H0YJW3|H0YJW3_HUMAN;tr|H7C5W8|H7C5W8_HUMAN;sp|P35609|ACTN2_HUMAN;tr|H0YJ11|H0YJ11_HUMAN;tr|G3V2X9|G3V2X9_HUMAN;sp|Q08043|ACTN3_HUMAN;tr|G3V5M4|G3V5M4_HUMAN;tr|F6THM6|F6THM6_HUMAN;tr|A0A087WSZ2|A0A087WSZ2_HUMAN;tr|G3V2E8|G3V2E8_HUMAN;tr|D6RH00|D6RH00_HUMAN;tr|G3V380|G3V380_HUMAN","sp|P12814|ACTN1_HUMAN;tr|H9KV75|H9KV75_HUMAN",1069,"P12814","ACTN1_HUMAN","Alpha-actinin-1",null,"ACTN1"]
["21.6133","19.3033","21.1122","18.6054","19.8951","20.8568",{"$nulls":3},"spermatogenesis","RNA binding","nucleus",{"$nulls":3},6,6,6,"18.6","18.6","18.6","40.241",0,"9.697",500750000,12,"0.392341",1,"0.890486","0.929617","sp|Q14320|FA50A_HUMAN;tr|B0S8I6|B0S8I6_HUMAN;sp|Q9Y247|FA50B_HUMAN","sp|Q14320|FA50A_HUMAN;tr|B0S8I6|B0S8I6_HUMAN",2466,"Q14320","FA50A_HUMAN","Protein FAM50A",null,"FAM50A"]
["22.9776","22.09","22.4912","21.4314","21.4335","22.0239",{"$nulls":5},"integral component of membrane",{"$nulls":3},5,5,5,"39.4","39.4","39.4","21.233",0,"39.611",461400000,26,"1.28932",1,"0.890001","2.75014","tr|A0A0A6YYA0|A0A0A6YYA0_HUMAN;sp|Q9Y3B3|TMED7_HUMAN;tr|G3V2Y2|G3V2Y2_HUMAN","tr|A0A0A6YYA0|A0A0A6YYA0_HUMAN;sp|Q9Y3B3|TMED7_HUMAN",5282,"A0A0A6YYA0","A0A0A6YYA0_HUMAN",null,null,"TMED7-TICAM2"]
["19.89","17.2369","18.1391","17.6675","17.9619","16.9681",{"$nulls":3},"cell cycle;cell division;DNA replication","DNA binding","nucleus",{"$nulls":3},6,6,6,"17.3","17.3","17.3","49.741",0,"12.253",87340000,6,"0.461379",1,"0.889474","1.06813","sp|Q6IQ49|SDE2_HUMAN","sp|Q6IQ49|SDE2_HUMAN",2967,"Q6IQ49","SDE2_HUMAN","Replication stress response regulator SDE2 {ECO:0000305}",null,"SDE2"]
["19.7844","17.7684","18.8246","17.7634","17.1579","18.795",{"$nulls":3},"branched-chain amino acid catabolic process;cellular nitrogen compound metabolic process","3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;alpha-ketoacid dehydrogenase activity;carboxy-lyase activity;metal ion binding","mitochondrial alpha-ketoglutarate dehydrogenase complex;mitochondrial matrix;mitochondrion","Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,6,6,6,"19.6","19.6","19.6","50.47",0,"11.069",230310000,6,"0.516792",1,"0.887021","1.17761","sp|P12694|ODBA_HUMAN;tr|F5H5P2|F5H5P2_HUMAN;tr|F5GXU9|F5GXU9_HUMAN;tr|M0R0C8|M0R0C8_HUMAN;tr|H0YH31|H0YH31_HUMAN","sp|P12694|ODBA_HUMAN;tr|F5H5P2|F5H5P2_HUMAN;tr|F5GXU9|F5GXU9_HUMAN;tr|M0R0C8|M0R0C8_HUMAN",1068,"P12694","ODBA_HUMAN","2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial",null,"BCKDHA"]
["22.8092","21.8222","22.1152","21.6615","20.8796","21.552",{"$nulls":3},"negative regulation of cell migration;neutrophil degranulation;platelet activation;platelet aggregation;positive regulation of protein autophosphorylation;Rap protein signal transduction;regulation of protein tyrosine kinase activity;signal transduction","GDP binding;GTP binding;GTPase activity;protein domain specific binding","bicellular tight junction;cell-cell contact zone;cytosol;extracellular exosome;membrane;membrane raft;plasma membrane;recycling endosome membrane;specific granule membrane;tertiary granule membrane",{"$nulls":3},10,10,6,"62.8","62.8","36.6","20.504",0,"138.55",416120000,29,"1.09063",1,"0.884538","2.31968","sp|P61225|RAP2B_HUMAN;tr|F6U784|F6U784_HUMAN","sp|P61225|RAP2B_HUMAN",1925,"P61225","RAP2B_HUMAN","Ras-related protein Rap-2b",null,"RAP2B"]
["22.8612","21.4182","21.9949","21.2896","20.8713","21.461",{"$nulls":3},"peptide metabolic process;regulation of gluconeogenesis;regulation of skeletal muscle fiber differentiation","metal ion binding;metalloendopeptidase activity;peptide binding","extracellular region;mitochondrial intermembrane space;plasma membrane","Renin-angiotensin system",null,null,21,21,21,"34.9","34.9","34.9","80.651",0,"103.81",1139200000,59,"0.908051",1,"0.884127","1.9456","sp|Q9BYT8|NEUL_HUMAN;tr|E9PCB6|E9PCB6_HUMAN;tr|H0YAK4|H0YAK4_HUMAN;tr|H0YAF7|H0YAF7_HUMAN","sp|Q9BYT8|NEUL_HUMAN;tr|E9PCB6|E9PCB6_HUMAN;tr|H0YAK4|H0YAK4_HUMAN",4319,"Q9BYT8","NEUL_HUMAN","Neurolysin, mitochondrial",null,"NLN"]
["22.347","20.7594","21.2896","21.3598","19.6562","20.7278",{"$nulls":3},"glycosaminoglycan metabolic process","metal ion binding;N-acetylglucosamine-6-sulfatase activity","lysosome",{"$nulls":3},9,9,9,"20.6","20.6","20.6","56.374",0,"28.731",493080000,20,"0.577515",1,"0.884091","1.29652","tr|H7C3P4|H7C3P4_HUMAN;sp|P15586|GNS_HUMAN;tr|F6S8M0|F6S8M0_HUMAN;tr|H0YFA9|H0YFA9_HUMAN;tr|F5H4C6|F5H4C6_HUMAN","tr|H7C3P4|H7C3P4_HUMAN;sp|P15586|GNS_HUMAN;tr|F6S8M0|F6S8M0_HUMAN;tr|H0YFA9|H0YFA9_HUMAN",1124,"H7C3P4","H7C3P4_HUMAN","N-acetylglucosamine-6-sulfatase {ECO:0000256|PIRNR:PIRNR036666}"]
["21.8729","22.7574","20.8735","19.9696","21.8276","21.057",{"$nulls":9},2,2,2,"51.2","51.2","51.2","4.7756",0,"5.9442",126710000,10,"0.504366",1,"0.883181","1.15316","tr|F8VQW0|F8VQW0_HUMAN;tr|F8VX73|F8VX73_HUMAN;tr|F8VPI1|F8VPI1_HUMAN;tr|F8W201|F8W201_HUMAN;tr|F8W086|F8W086_HUMAN;tr|F8VR05|F8VR05_HUMAN;tr|F8VQQ5|F8VQQ5_HUMAN;tr|F8VSI7|F8VSI7_HUMAN;tr|F8VVJ4|F8VVJ4_HUMAN;sp|P55061|BI1_HUMAN;tr|F8W1G3|F8W1G3_HUMAN","tr|F8VQW0|F8VQW0_HUMAN;tr|F8VX73|F8VX73_HUMAN;tr|F8VPI1|F8VPI1_HUMAN;tr|F8W201|F8W201_HUMAN;tr|F8W086|F8W086_HUMAN;tr|F8VR05|F8VR05_HUMAN;tr|F8VQQ5|F8VQQ5_HUMAN;tr|F8VSI7|F8VSI7_HUMAN;tr|F8VVJ4|F8VVJ4_HUMAN;sp|P55061|BI1_HUMAN;tr|F8W1G3|F8W1G3_HUMAN",1835,"F8VQW0","F8VQW0_HUMAN",null,null,"TMBIM6"]
["17.9949","17.9611","18.7614","18.3766","16.6423","17.0593",{"$nulls":3},"cell adhesion;mRNA splicing, via spliceosome;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;RNA binding;structural molecule activity","catalytic step 2 spliceosome;cell-cell junction;desmosome;intermediate filament;membrane;nuclear speck;plasma membrane","mRNA surveillance pathway;RNA transport",null,null,9,9,9,18,18,18,"81.613",0,"33.434",134010000,17,"0.684743",1,"0.879716","1.50547","sp|Q9H307|PININ_HUMAN;tr|G3V5F0|G3V5F0_HUMAN;tr|G3V579|G3V579_HUMAN","sp|Q9H307|PININ_HUMAN",4441,"Q9H307","PININ_HUMAN","Pinin",null,"PNN"]
["19.1325","16.402","18.8335","17.5257","16.2445","17.9595",{"$nulls":3},"prolyl-tRNA aminoacylation","ATP binding;proline-tRNA ligase activity","mitochondrial matrix","Aminoacyl-tRNA biosynthesis",null,null,5,5,5,"15.2","15.2","15.2","53.262",0,"35.751",117720000,17,"0.365043",1,"0.879473","0.873953","sp|Q7L3T8|SYPM_HUMAN","sp|Q7L3T8|SYPM_HUMAN",3122,"Q7L3T8","SYPM_HUMAN","Probable proline--tRNA ligase, mitochondrial",null,"PARS2"]
["23.7189","23.6526","23.7342","23.1673","22.1935","23.1077",{"$nulls":3},"positive regulation of protein localization to plasma membrane;retrograde vesicle-mediated transport, Golgi to ER;skeletal muscle acetylcholine-gated channel clustering","acetylcholine receptor binding","cell surface;endoplasmic reticulum-Golgi intermediate compartment;Golgi apparatus;integral component of Golgi membrane;plasma membrane",{"$nulls":3},7,7,7,"34.2","34.2","34.2","22.958",0,"69.526",2115300000,58,"1.30287",1,"0.879072","2.7806","sp|O15258|RER1_HUMAN;tr|Q9P0H9|Q9P0H9_HUMAN;tr|Q5T092|Q5T092_HUMAN;tr|A0A0A0MR06|A0A0A0MR06_HUMAN;tr|Q5T091|Q5T091_HUMAN;tr|Q5T093|Q5T093_HUMAN","sp|O15258|RER1_HUMAN;tr|Q9P0H9|Q9P0H9_HUMAN;tr|Q5T092|Q5T092_HUMAN;tr|A0A0A0MR06|A0A0A0MR06_HUMAN;tr|Q5T091|Q5T091_HUMAN;tr|Q5T093|Q5T093_HUMAN",353,"O15258","RER1_HUMAN","Protein RER1",null,"RER1"]
["22.4914","20.3742","21.7376","21.1361","19.7916","21.0411",{"$nulls":3},"prenylated protein catabolic process;prenylcysteine catabolic process;prenylcysteine metabolic process","chloride-transporting ATPase activity;prenylcysteine oxidase activity","extracellular exosome;lysosome;plasma membrane;vacuolar membrane;very-low-density lipoprotein particle","Terpenoid backbone biosynthesis",null,null,14,14,14,"38.2","38.2","38.2","56.639",0,"83.391",632100000,39,"0.508639",1,"0.878145","1.16157","sp|Q9UHG3|PCYOX_HUMAN;tr|F8W8W4|F8W8W4_HUMAN;tr|C9K055|C9K055_HUMAN;tr|C9JM55|C9JM55_HUMAN;tr|C9JGT6|C9JGT6_HUMAN","sp|Q9UHG3|PCYOX_HUMAN;tr|F8W8W4|F8W8W4_HUMAN",5023,"Q9UHG3","PCYOX_HUMAN","Prenylcysteine oxidase 1",null,"PCYOX1"]
["23.8199","22.4665","22.4481","22.4821","22.0408","21.5792",{"$nulls":3},"biosynthetic process","arylesterase activity;strictosidine synthase activity","cell surface;endoplasmic reticulum;extracellular exosome;integral component of membrane;membrane",{"$nulls":3},15,15,15,45,45,45,"46.48",0,"104.18",1582800000,72,"0.77175",1,"0.877476","1.67552","sp|Q9HDC9|APMAP_HUMAN;tr|H0Y512|H0Y512_HUMAN","sp|Q9HDC9|APMAP_HUMAN;tr|H0Y512|H0Y512_HUMAN",4615,"Q9HDC9","APMAP_HUMAN","Adipocyte plasma membrane-associated protein",null,"APMAP"]
["21.306","17.98","18.9721","19.0261","17.6401","18.963",{"$nulls":3},"carbohydrate metabolic process;cytoplasmic mRNA processing body assembly;deadenylation-dependent decapping of nuclear-transcribed mRNA;defense response to virus;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;gene silencing by miRNA;gene silencing by RNA;negative regulation of cell proliferation;negative regulation of gene expression;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of type I interferon-mediated signaling pathway;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of cell proliferation;positive regulation of mRNA catabolic process;positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral genome replication;regulation of tyrosine phosphorylation of STAT protein;signal transduction;transcription, DNA-templated","3'-5'-exoribonuclease activity;DNA binding transcription factor activity;exoribonuclease activity;metal ion binding;poly(A)-specific ribonuclease activity;RNA binding;signal transducer activity;transcription factor binding;transcriptional repressor activity, RNA polymerase II transcription factor binding","CCR4-NOT complex;CCR4-NOT core complex;cytoplasm;cytosol;host cell PML body;membrane;nuclear body;nuclear speck;nucleus;P-body","RNA degradation",null,null,5,5,5,27,27,27,"32.745",0,"12.545",91453000,6,"0.333133",1,"0.876299","0.808055","sp|Q9UIV1|CNOT7_HUMAN;tr|H0YAV9|H0YAV9_HUMAN;tr|E5RGH2|E5RGH2_HUMAN;tr|H0YBT3|H0YBT3_HUMAN","sp|Q9UIV1|CNOT7_HUMAN;tr|H0YAV9|H0YAV9_HUMAN",5055,"Q9UIV1","CNOT7_HUMAN","CCR4-NOT transcription complex subunit 7",null,"CNOT7"]
["20.8853","21.0806","20.5941","20.4916","19.7286","19.7169",{"$nulls":3},"cellular nitrogen compound metabolic process;mitochondrial acetyl-CoA biosynthetic process from pyruvate;pyruvate metabolic process;regulation of acetyl-CoA biosynthetic process from pyruvate","transferase activity, transferring acyl groups","mitochondrial matrix;pyruvate dehydrogenase complex","Metabolic pathways",null,null,10,10,10,"28.9","28.9","28.9","54.122",0,"64.096",360780000,34,"1.39308",1,"0.874306","2.98718","sp|O00330|ODPX_HUMAN;tr|H0YD97|H0YD97_HUMAN;tr|E9PLU0|E9PLU0_HUMAN;tr|E9PRI6|E9PRI6_HUMAN","sp|O00330|ODPX_HUMAN",227,"O00330","ODPX_HUMAN","Pyruvate dehydrogenase protein X component, mitochondrial",null,"PDHX"]
["18.7114","18.1045","17.4669","17.2084","17.6312","16.822",{"$nulls":3},"defense response to virus;interferon-beta production;protein K63-linked ubiquitination;regulation of type I interferon production;response to type I interferon","RNA binding;ubiquitin-protein transferase activity;zinc ion binding","cytoplasm;cytosol",{"$nulls":3},5,5,5,"7.5","7.5","7.5","81.487",0,"12.556",104160000,11,"0.954226",1,"0.873737","2.03864","sp|Q9BRZ2|TRI56_HUMAN;sp|Q15834|CC85B_HUMAN;tr|C9JI91|C9JI91_HUMAN","sp|Q9BRZ2|TRI56_HUMAN",4178,"Q9BRZ2","TRI56_HUMAN","E3 ubiquitin-protein ligase TRIM56",null,"TRIM56"]
["21.3959","20.4745","20.4635","19.8834","19.2667","20.5633",{"$nulls":3},"aerobic respiration;ATP biosynthetic process;mitochondrial respiratory chain complex IV assembly;oxidation-reduction process;oxidative phosphorylation;respiratory chain complex IV assembly","cytochrome-c oxidase activity","integral component of membrane;mitochondrial respiratory chain",{"$nulls":3},4,4,4,"21.3","21.3","21.3","33.331",0,"10.955",252660000,25,"0.834614",1,"0.873526","1.79936","sp|Q15526|SURF1_HUMAN;tr|A0A087WYS9|A0A087WYS9_HUMAN","sp|Q15526|SURF1_HUMAN;tr|A0A087WYS9|A0A087WYS9_HUMAN",2608,"Q15526","SURF1_HUMAN","Surfeit locus protein 1",null,"SURF1"]
["22.4547","20.6071","21.7468","21.0614","19.5411","21.5925",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","hydrolase activity;structural constituent of ribosome","cell junction;mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion;nucleoplasm",{"$nulls":3},8,8,8,"41.9","41.9","41.9","31.705",0,"171.12",525230000,49,"0.460478",1,"0.871201","1.06634","sp|Q9H2W6|RM46_HUMAN;tr|A0A087WT90|A0A087WT90_HUMAN;tr|A0A087WT51|A0A087WT51_HUMAN","sp|Q9H2W6|RM46_HUMAN",4440,"Q9H2W6","RM46_HUMAN","39S ribosomal protein L46, mitochondrial","46mt;RP-L46","MRPL46"]
["22.0105","21.1916","21.8196","21.243","19.5416","21.631",{"$nulls":3},"positive regulation of cell growth",null,"nucleus",{"$nulls":3},16,15,15,27,"25.8","25.8","74.316",0,"139.67",1584200000,90,"0.560452",1,"0.868668","1.26318","sp|Q7Z4V5|HDGR2_HUMAN;tr|M0R0J3|M0R0J3_HUMAN;tr|K7EPS6|K7EPS6_HUMAN;tr|A0A087WX58|A0A087WX58_HUMAN;tr|A0A087WZ99|A0A087WZ99_HUMAN;tr|A0A087WT54|A0A087WT54_HUMAN;tr|A0A024R216|A0A024R216_HUMAN;sp|Q9Y3E1|HDGR3_HUMAN;tr|K7EJP7|K7EJP7_HUMAN;tr|K7ERA4|K7ERA4_HUMAN","sp|Q7Z4V5|HDGR2_HUMAN",3172,"Q7Z4V5","HDGR2_HUMAN","Hepatoma-derived growth factor-related protein 2","RP-2","HDGFL2"]
["21.4364","20.7274","20.9362","20.4416","19.7487","20.3104",{"$nulls":3},"dATP catabolic process;defense response to virus;deoxyribonucleotide catabolic process;dGTP catabolic process;immune response;protein homotetramerization;regulation of innate immune response;type I interferon signaling pathway","dGTP binding;dGTPase activity;identical protein binding;nucleic acid binding;ribonuclease activity;RNA binding;triphosphoric monoester hydrolase activity;zinc ion binding","intracellular;nucleoplasm;nucleus;plasma membrane","Human immunodeficiency virus 1 infection",null,null,18,18,18,"31.9","31.9","31.9","72.2",0,"60.93",650470000,67,"1.35439",1,"0.866454","2.89772","sp|Q9Y3Z3|SAMH1_HUMAN","sp|Q9Y3Z3|SAMH1_HUMAN",5310,"Q9Y3Z3","SAMH1_HUMAN","Deoxynucleoside triphosphate triphosphohydrolase SAMHD1","NTPase","SAMHD1"]
["21.0542","18.4822","19.6986","20.3592","16.697","19.5801",{"$nulls":3},"canonical glycolysis;glucose metabolic process","ADP-specific glucokinase activity;metal ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular region;membrane","Carbon metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways",null,null,6,6,6,"22.1","22.1","22.1","54.088",0,"49.853",118290000,21,"0.257389",1,"0.86628","0.647057","sp|Q9BRR6|ADPGK_HUMAN;tr|H3BRS6|H3BRS6_HUMAN;tr|H3BTH4|H3BTH4_HUMAN;tr|H3BN66|H3BN66_HUMAN;tr|H3BU35|H3BU35_HUMAN","sp|Q9BRR6|ADPGK_HUMAN;tr|H3BRS6|H3BRS6_HUMAN",4170,"Q9BRR6","ADPGK_HUMAN","ADP-dependent glucokinase","DPGK;DP-GK","ADPGK"]
["20.5451","19.1296","20.19","19.83","18.083","19.3532",{"$nulls":3},"determination of ventral identity;dorsal/ventral pattern formation;negative regulation of JNK cascade;negative regulation of JUN kinase activity;regulation of protein homodimerization activity","phosphatidylinositol binding;protein domain specific binding","cytoplasm;membrane",{"$nulls":3},7,7,7,"34.6","34.6","34.6","35.023",0,"25.053",131660000,23,"0.572895",1,"0.866176","1.2875","sp|Q96BJ3|AIDA_HUMAN","sp|Q96BJ3|AIDA_HUMAN",3803,"Q96BJ3","AIDA_HUMAN","Axin interactor, dorsalization-associated protein",null,"AIDA"]
["21.8236","20.0128","21.1004","20.2081","19.1209","21.0119",{"$nulls":3},"dephosphorylation of RNA polymerase II C-terminal domain;snRNA transcription from RNA polymerase II promoter","identical protein binding","DNA-directed RNA polymerase II, holoenzyme;nucleoplasm",{"$nulls":3},9,7,7,"42.3","30.4","30.4","35.719",0,"33.592",293180000,21,"0.497166",1,"0.865281","1.13896","sp|Q96P16|RPR1A_HUMAN;tr|A0A0C4DGQ6|A0A0C4DGQ6_HUMAN;tr|K7ER50|K7ER50_HUMAN;tr|K7EP82|K7EP82_HUMAN","sp|Q96P16|RPR1A_HUMAN;tr|A0A0C4DGQ6|A0A0C4DGQ6_HUMAN",3986,"Q96P16","RPR1A_HUMAN","Regulation of nuclear pre-mRNA domain-containing protein 1A",null,"RPRD1A"]
["19.5427","17.3537","18.4248","17.6764","16.9887","18.0637",{"$nulls":3},"NAD biosynthesis via nicotinamide riboside salvage pathway","ADP-dependent NAD(P)H-hydrate dehydratase activity;ATP binding;ATP-dependent NAD(P)H-hydrate dehydratase activity","mitochondrial matrix",{"$nulls":3},3,3,3,"12.1","12.1","12.1","36.576","0.00042026","4.4899",51189000,7,"0.540612",1,"0.864153","1.22435","sp|Q8IW45|NNRD_HUMAN","sp|Q8IW45|NNRD_HUMAN",3298,"Q8IW45","NNRD_HUMAN","ATP-dependent (S)-NAD(P)H-hydrate dehydratase {ECO:0000255|HAMAP-Rule:MF_03157}",null,"NAXD"]
["21.0666","19.6255","20.797","19.5648","19.5905","19.7449",{"$nulls":3},"biotin metabolic process;branched-chain amino acid catabolic process;coenzyme A metabolic process;leucine catabolic process;protein heterooligomerization","ATP binding;methylcrotonoyl-CoA carboxylase activity","3-methylcrotonyl-CoA carboxylase complex, mitochondrial;cytosol;methylcrotonoyl-CoA carboxylase complex;mitochondrial matrix;mitochondrion","Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,22,22,22,"56.1","56.1","56.1","61.332",0,"108.59",679400000,58,"0.902922",1,"0.862979","1.93532","sp|Q9HCC0|MCCB_HUMAN;tr|D6RDF7|D6RDF7_HUMAN;tr|D6R9R1|D6R9R1_HUMAN;tr|D6RD67|D6RD67_HUMAN;tr|A0A0G2JM88|A0A0G2JM88_HUMAN","sp|Q9HCC0|MCCB_HUMAN;tr|D6RDF7|D6RDF7_HUMAN",4588,"Q9HCC0","MCCB_HUMAN","Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial","CCase subunit beta","MCCC2"]
["19.3001","18.72","19.6899","19.8522","16.6648","18.6197",{"$nulls":5},"mitochondrion;nucleus",{"$nulls":3},4,4,4,28,28,28,"23.128",0,"8.0001",102050000,8,"0.370173",1,"0.857751","0.884458","sp|Q8WW59|SPRY4_HUMAN","sp|Q8WW59|SPRY4_HUMAN",3632,"Q8WW59","SPRY4_HUMAN","SPRY domain-containing protein 4",null,"SPRYD4"]
["20.0319","16.3303","17.1599","16.2569","17.7261","16.9687",{"$nulls":3},"activation of blood coagulation via clotting cascade;bleb assembly;blood coagulation;bone mineralization involved in bone maturation;calcium activated galactosylceramide scrambling;calcium activated phosphatidylcholine scrambling;calcium activated phosphatidylserine scrambling;calcium ion transmembrane transport;cation transport;chloride transmembrane transport;chloride transport;dendritic cell chemotaxis;ion transmembrane transport;negative regulation of cell volume;neutrophil degranulation;phosphatidylserine exposure on blood platelet;phospholipid scrambling;pore complex assembly;positive regulation of apoptotic process;positive regulation of bone mineralization;positive regulation of endothelial cell apoptotic process;positive regulation of ion transmembrane transport;positive regulation of monocyte chemotaxis;positive regulation of phagocytosis, engulfment;positive regulation of potassium ion export;purinergic nucleotide receptor signaling pathway;sodium ion transmembrane transport","calcium activated cation channel activity;intracellular calcium activated chloride channel activity;phospholipid scramblase activity;protein homodimerization activity;voltage-gated chloride channel activity;voltage-gated ion channel activity","cell surface;chloride channel complex;cytosol;extracellular exosome;intracellular;membrane;plasma membrane;specific granule membrane;tertiary granule membrane",{"$nulls":3},2,2,2,"3.5","3.5","3.5","106.16",0,"24.789",270480000,14,"0.28871",1,"0.856726","0.714523","sp|Q4KMQ2|ANO6_HUMAN","sp|Q4KMQ2|ANO6_HUMAN",2759,"Q4KMQ2","ANO6_HUMAN","Anoctamin-6",null,"ANO6"]
["21.3006","19.8726","20.6069","19.8783","19.264","20.072",{"$nulls":3},"cell growth;rRNA modification;rRNA processing;snoRNA localization","ATPase binding;RNA binding;snoRNA binding;TFIID-class transcription factor binding","box C/D snoRNP complex;Cajal body;cytosol;fibrillar center;membrane;nucleolus;nucleoplasm;nucleus;pre-snoRNP complex;small nucleolar ribonucleoprotein complex;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,20,20,20,"46.3","46.3","46.3","59.578",0,"261.6",1924100000,177,"0.827914",1,"0.855288","1.78611","sp|Q9Y2X3|NOP58_HUMAN;tr|H7BZ72|H7BZ72_HUMAN;tr|F8WED0|F8WED0_HUMAN","sp|Q9Y2X3|NOP58_HUMAN",5251,"Q9Y2X3","NOP58_HUMAN","Nucleolar protein 58",null,"NOP58"]
["21.8519","20.9521","21.1083","20.8945","19.6198","20.8336",{"$nulls":3},"actin filament capping;axon guidance;ER to Golgi vesicle-mediated transport;MAPK cascade;neutrophil degranulation","actin binding;cadherin binding;calcium ion binding;calmodulin binding;Ras guanyl-nucleotide exchange factor activity;structural constituent of cytoskeleton","cytosol;extracellular exosome;extracellular region;extracellular vesicle;intracellular membrane-bounded organelle;membrane;microtubule cytoskeleton;specific granule lumen;spectrin;tertiary granule lumen","Apoptosis",null,null,85,85,85,"44.7","44.7","44.7","284.54",0,"323.31",3156800000,265,"0.790242",1,"0.854826","1.71184","sp|Q13813|SPTN1_HUMAN;tr|A0A0D9SGF6|A0A0D9SGF6_HUMAN;tr|A0A0D9SF54|A0A0D9SF54_HUMAN;tr|A0A0D9SFF6|A0A0D9SFF6_HUMAN;tr|A0A0D9SFH4|A0A0D9SFH4_HUMAN","sp|Q13813|SPTN1_HUMAN;tr|A0A0D9SGF6|A0A0D9SGF6_HUMAN;tr|A0A0D9SF54|A0A0D9SF54_HUMAN",2410,"Q13813","SPTN1_HUMAN","Spectrin alpha chain, non-erythrocytic 1",null,"SPTAN1"]
["18.5856","16.8966",1,"18.0088","14.9094",1,{"$nulls":3},"cell adhesion;leukocyte migration;neutrophil degranulation","SH3 domain binding","extracellular exosome;ficolin-1-rich granule membrane;integral component of membrane;membrane;plasma membrane;tertiary granule membrane","Osteoclast differentiation",null,null,3,3,3,"8.9","8.9","8.9","54.966",0,"6.0892",62274000,8,"0.0378331",1,"0.85469","0.111524","sp|P78324|SHPS1_HUMAN;sp|Q5TFQ8|SIRBL_HUMAN;tr|H3BU43|H3BU43_HUMAN;tr|H3BSK5|H3BSK5_HUMAN;tr|H3BQ21|H3BQ21_HUMAN","sp|P78324|SHPS1_HUMAN;sp|Q5TFQ8|SIRBL_HUMAN",2053,"P78324","SHPS1_HUMAN","Tyrosine-protein phosphatase non-receptor type substrate 1","HP substrate 1;HPS-1","SIRPA"]
["20.7332","18.3901","19.0249","19.1638","18.3522","18.0687",{"$nulls":3},"adult locomotory behavior;developmental growth;microtubule cytoskeleton organization;mitotic spindle organization;muscle atrophy;peripheral nervous system neuron axonogenesis;post-chaperonin tubulin folding pathway;post-embryonic development;protein folding","chaperone binding","cytoplasm;microtubule",{"$nulls":3},12,12,12,"30.6","30.6","30.6","59.345",0,"77.188",214030000,20,"0.480356",1,"0.854525","1.10576","sp|Q15813|TBCE_HUMAN","sp|Q15813|TBCE_HUMAN",2646,"Q15813","TBCE_HUMAN","Tubulin-specific chaperone E",null,"TBCE"]
["19.2102","17.5118","18.6826","18.7131","15.4623","18.6662",{"$nulls":3},"heart formation;meiotic attachment of telomere to nuclear envelope;negative regulation of BMP signaling pathway;negative regulation of MAPK cascade;negative regulation of protein kinase B signaling;neurogenesis;nuclear envelope organization;protein localization to chromatin;skeletal muscle cell differentiation","chromatin DNA binding","integral component of membrane;integral component of nuclear inner membrane;membrane;nuclear inner membrane;nuclear membrane",{"$nulls":3},11,11,11,"28.8","28.8","28.8","56.974",0,"49.132",354570000,40,"0.291118",1,"0.854344","0.719654","sp|Q8NC56|LEMD2_HUMAN;tr|H7C2Z0|H7C2Z0_HUMAN;tr|H0Y9B7|H0Y9B7_HUMAN;tr|D6R958|D6R958_HUMAN;tr|D6RBV0|D6RBV0_HUMAN;tr|H0Y8H8|H0Y8H8_HUMAN","sp|Q8NC56|LEMD2_HUMAN",3468,"Q8NC56","LEMD2_HUMAN","LEM domain-containing protein 2","LEM2","LEMD2"]
["22.1499","21.4761","22.0331","20.9722","21.0094","21.1193",{"$nulls":3},"guanine catabolic process;guanine metabolic process;nervous system development;nucleobase-containing compound metabolic process;purine nucleotide catabolic process","guanine deaminase activity;zinc ion binding","cytosol;extracellular exosome;intracellular","Metabolic pathways;Purine metabolism",null,null,15,15,15,"44.9","44.9","44.9","51.002",0,"140.35",650100000,51,"1.79685",1,"0.852709","4.01243","sp|Q9Y2T3|GUAD_HUMAN;tr|Q5SZC6|Q5SZC6_HUMAN;tr|H0YDZ7|H0YDZ7_HUMAN;tr|Q5SZC3|Q5SZC3_HUMAN;tr|Q5SZC5|Q5SZC5_HUMAN","sp|Q9Y2T3|GUAD_HUMAN;tr|Q5SZC6|Q5SZC6_HUMAN",5242,"Q9Y2T3","GUAD_HUMAN","Guanine deaminase","uanase;uanine aminase","GDA"]
["24.9886","23.5845","24.0462","23.6991","22.4685","23.8956",{"$nulls":3},"cellular response to leukemia inhibitory factor;chromosome segregation;negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of cell proliferation;regulation of insulin secretion;transport;viral process","adenine transmembrane transporter activity;ATP:ADP antiporter activity;RNA binding;ubiquitin protein ligase binding","extracellular exosome;extracellular matrix;integral component of plasma membrane;membrane;membrane raft;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrion;MMXD complex;myelin sheath;nucleus","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Necroptosis;Parkinson disease",null,null,17,6,6,"48.3","21.8","21.8","32.852",0,"30.035",9110500000,208,"0.630841",1,"0.852026","1.40048","sp|P05141|ADT2_HUMAN","sp|P05141|ADT2_HUMAN",895,"P05141","ADT2_HUMAN","ADP/ATP translocase 2",null,"SLC25A5"]
["22.5884","22.6965","22.3806","20.6741","22.2169","22.22",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial ribosome;mitochondrial small ribosomal subunit","Ribosome",null,null,3,3,3,"28.9","28.9","28.9","15.139",0,"34.595",380660000,31,"0.747493",1,"0.851529","1.62799","sp|O60783|RT14_HUMAN","sp|O60783|RT14_HUMAN",523,"O60783","RT14_HUMAN","28S ribosomal protein S14, mitochondrial","14mt;RP-S14","MRPS14"]
["23.1788","21.0786","22.1006","21.9836","20.5028","21.3195",{"$nulls":3},"cell redox homeostasis;glycoprotein metabolic process;neutrophil degranulation;protein folding;response to endoplasmic reticulum stress;response to unfolded protein","protein disulfide isomerase activity","cell surface;endoplasmic reticulum lumen;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular region;specific granule lumen",{"$nulls":3},13,13,13,"39.4","39.4","39.4","46.971",0,"135.62",691850000,50,"0.500736",1,"0.850691","1.146","sp|Q9BS26|ERP44_HUMAN","sp|Q9BS26|ERP44_HUMAN",4179,"Q9BS26","ERP44_HUMAN","Endoplasmic reticulum resident protein 44","R protein 44;Rp44","ERP44"]
["22.1687","21.5693","21.6533","21.3826","20.1837","21.2782",{"$nulls":3},"co-translational protein modification;post-translational protein modification;protein N-linked glycosylation via asparagine","dolichyl-diphosphooligosaccharide-protein glycotransferase activity;metal ion binding","endoplasmic reticulum membrane;integral component of membrane;membrane;oligosaccharyltransferase complex","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,14,14,13,20,20,19,"80.529",0,"50.106",861370000,63,"0.929807",1,"0.848915","1.98932","sp|P46977|STT3A_HUMAN;tr|A0A0C4DH80|A0A0C4DH80_HUMAN;tr|E9PN73|E9PN73_HUMAN;tr|E9PI32|E9PI32_HUMAN;tr|H0YET6|H0YET6_HUMAN","sp|P46977|STT3A_HUMAN",1609,"P46977","STT3A_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A","ligosaccharyl transferase subunit STT3A;TT3-A","STT3A"]
["23.0388",1,"22.5192","21.4216",1,"21.5907",{"$nulls":3},"detection of calcium ion;Fc-epsilon receptor signaling pathway;glycogen catabolic process;inositol phosphate metabolic process;MAPK cascade;muscle contraction;negative regulation of peptidyl-threonine phosphorylation;negative regulation of ryanodine-sensitive calcium-release channel activity;platelet degranulation;positive regulation of cAMP biosynthetic process;positive regulation of cyclic nucleotide metabolic process;positive regulation of cyclic-nucleotide phosphodiesterase activity;positive regulation of peptidyl-threonine phosphorylation;positive regulation of phosphoprotein phosphatase activity;positive regulation of protein autophosphorylation;positive regulation of protein dephosphorylation;positive regulation of protein serine/threonine kinase activity;positive regulation of ryanodine-sensitive calcium-release channel activity;protein methylation;regulation of cardiac muscle contraction;regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;regulation of cell communication by electrical coupling involved in cardiac conduction;regulation of heart rate;regulation of nitric-oxide synthase activity;regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;regulation of rhodopsin mediated signaling pathway;regulation of ryanodine-sensitive calcium-release channel activity;response to calcium ion;Wnt signaling pathway, calcium modulating pathway","adenylate cyclase binding;calcium channel inhibitor activity;calcium ion binding;disordered domain specific binding;inositol-1,4,5-trisphosphate 3-kinase activity;ion channel binding;ligand-gated ion channel activity;protein kinase binding;protein phosphatase activator activity;protein serine/threonine kinase activator activity;Ras guanyl-nucleotide exchange factor activity;titin binding","catalytic complex;cytoplasm;cytosol;extracellular region;nucleoplasm;plasma membrane;protein complex;sarcomere;spindle pole","Adrenergic signaling in cardiomyocytes;Alcoholism;Aldosterone synthesis and secretion;Alzheimer disease;Amphetamine addiction;Apelin signaling pathway;Calcium signaling pathway;cAMP signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Circadian entrainment;C-type lectin receptor signaling pathway;Dopaminergic synapse;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;Gastric acid secretion;Glioma;Glucagon signaling pathway;GnRH signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term potentiation;Melanogenesis;Neurotrophin signaling pathway;Olfactory transduction;Oocyte meiosis;Oxytocin signaling pathway;Pathways in cancer;Pertussis;Phosphatidylinositol signaling system;Phototransduction;Rap1 signaling pathway;Ras signaling pathway;Renin secretion;Salivary secretion;Tuberculosis;Vascular smooth muscle contraction",null,null,5,5,5,"35.6","35.6","35.6","16.837",0,"49.342",318170000,27,"0.028595",1,"0.84856","0.0850903","sp|P62158|CALM_HUMAN;tr|H0Y7A7|H0Y7A7_HUMAN;tr|E7ETZ0|E7ETZ0_HUMAN;tr|E7EMB3|E7EMB3_HUMAN;tr|F8WBR5|F8WBR5_HUMAN;tr|M0QZ52|M0QZ52_HUMAN;tr|G3V479|G3V479_HUMAN;tr|G3V361|G3V361_HUMAN;tr|Q96HY3|Q96HY3_HUMAN;sp|P27482|CALL3_HUMAN;tr|G3V226|G3V226_HUMAN;tr|C9J7T9|C9J7T9_HUMAN;sp|P02585|TNNC2_HUMAN","sp|P62158|CALM_HUMAN;tr|H0Y7A7|H0Y7A7_HUMAN;tr|E7ETZ0|E7ETZ0_HUMAN;tr|E7EMB3|E7EMB3_HUMAN;tr|F8WBR5|F8WBR5_HUMAN;tr|M0QZ52|M0QZ52_HUMAN;tr|G3V479|G3V479_HUMAN",1956,"P62158","CALM1_HUMAN","Calmodulin-1 {ECO:0000312|HGNC:HGNC:1442}",null,"CALM1"]
["20.183","20.005","19.9611","19.2695","19.0959","19.2427",{"$nulls":3},"actin cytoskeleton reorganization;activation of protein kinase activity;apoptotic process;branching morphogenesis of an epithelial tube;cellular response to insulin stimulus;cerebellum development;ephrin receptor signaling pathway;establishment of cell polarity;exocytosis;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;hepatocyte growth factor receptor signaling pathway;negative regulation of cell growth involved in cardiac muscle cell development;negative regulation of cell proliferation involved in contact inhibition;neuron projection morphogenesis;positive regulation of axon extension;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of fibroblast migration;positive regulation of glucose import in response to insulin stimulus;positive regulation of intracellular estrogen receptor signaling pathway;positive regulation of JUN kinase activity;positive regulation of microtubule polymerization;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein phosphorylation;positive regulation of protein targeting to membrane;positive regulation of stress fiber assembly;positive regulation of vascular associated smooth muscle cell migration;positive regulation of vascular smooth muscle cell proliferation;protein autophosphorylation;protein phosphorylation;regulation of apoptotic process;regulation of axonogenesis;regulation of mitotic cell cycle;response to hypoxia;Rho protein signal transduction;stimulatory C-type lectin receptor signaling pathway;T cell costimulation;T cell receptor signaling pathway;wound healing","ATP binding;collagen binding;identical protein binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;Rac GTPase binding","axon;cell-cell junction;cytoplasm;cytosol;dendrite;focal adhesion;intercalated disc;invadopodium;lamellipodium;nuclear membrane;plasma membrane;protein complex;ruffle;ruffle membrane;Z disc","Axon guidance;cAMP signaling pathway;Chemokine signaling pathway;C-type lectin receptor signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Fc gamma R-mediated phagocytosis;Focal adhesion;Hippo signaling pathway - multiple species;Human immunodeficiency virus 1 infection;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;Proteoglycans in cancer;Ras signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway",null,null,13,9,7,"33.9","22.9","18.9","60.646",0,"34.881",243340000,34,"3.2113",1,"0.846987","9.7708","sp|Q13153|PAK1_HUMAN;tr|B3KNX7|B3KNX7_HUMAN;tr|E9PM17|E9PM17_HUMAN;tr|H0YCG5|H0YCG5_HUMAN;tr|H0YCM0|H0YCM0_HUMAN;tr|E9PJF8|E9PJF8_HUMAN;tr|E9PRP6|E9PRP6_HUMAN;tr|E9PMP2|E9PMP2_HUMAN;tr|E9PQW5|E9PQW5_HUMAN;tr|E9PKH9|E9PKH9_HUMAN","sp|Q13153|PAK1_HUMAN;tr|B3KNX7|B3KNX7_HUMAN;tr|E9PM17|E9PM17_HUMAN",2316,"Q13153","PAK1_HUMAN","Serine/threonine-protein kinase PAK 1 {ECO:0000303|PubMed:8805275}",null,"PAK1"]
["22.7366","17.4685","21.9124","21.1763","17.7461","20.6546",{"$nulls":3},"cyanate catabolic process;epithelial cell differentiation;rRNA import into mitochondrion;rRNA transport","5S rRNA binding;thiosulfate sulfurtransferase activity","extracellular exosome;extracellular space;mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Cysteine and methionine metabolism;Metabolic pathways;Sulfur metabolism;Sulfur relay system",null,null,8,8,8,"32.7","32.7","32.7","33.429",0,"46.745",466980000,25,"0.163059",1,"0.846853","0.433547","sp|Q16762|THTR_HUMAN;tr|B1AH48|B1AH48_HUMAN","sp|Q16762|THTR_HUMAN",2691,"Q16762","THTR_HUMAN","Thiosulfate sulfurtransferase",null,"TST"]
["21.0915","21.6443","21.9389","20.7359","20.7082","20.6931",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;neutrophil degranulation","NADH dehydrogenase (ubiquinone) activity","azurophil granule membrane;cytoplasm;integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion;plasma membrane","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,5,5,5,"30.3","30.3","30.3","14.187",0,"8.0615",182960000,9,"1.56458",1,"0.845822","3.40095","sp|O95298|NDUC2_HUMAN;tr|E9PRJ5|E9PRJ5_HUMAN;tr|E9PM14|E9PM14_HUMAN;sp|E9PQ53|NDUCR_HUMAN;tr|A0A087WUM3|A0A087WUM3_HUMAN;tr|E9PRQ4|E9PRQ4_HUMAN;tr|A0A087WY27|A0A087WY27_HUMAN","sp|O95298|NDUC2_HUMAN",738,"O95298","NDUC2_HUMAN","NADH dehydrogenase [ubiquinone] 1 subunit C2",null,"NDUFC2"]
["19.4694",1,"18.715","18.4591",1,"17.1888",{"$nulls":3},"cell adhesion;cell proliferation;ectopic germ cell programmed cell death;embryonic hemopoiesis;extrinsic apoptotic signaling pathway in absence of ligand;male gonad development;MAPK cascade;negative regulation of mast cell apoptotic process;neural crest cell migration;ovarian follicle development;positive regulation of DNA replication;positive regulation of hematopoietic stem cell proliferation;positive regulation of leukocyte migration;positive regulation of MAP kinase activity;positive regulation of mast cell proliferation;positive regulation of melanocyte differentiation;positive regulation of myeloid leukocyte differentiation;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of protein kinase B signaling;positive regulation of Ras protein signal transduction;signal transduction","cytokine activity;growth factor activity;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;Ras guanyl-nucleotide exchange factor activity;stem cell factor receptor binding","cytoplasm;cytoskeleton;extracellular region;extracellular space;filopodium;integral component of membrane;lamellipodium;plasma membrane","Hematopoietic cell lineage;MAPK signaling pathway;Melanogenesis;Pathways in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Rap1 signaling pathway;Ras signaling pathway",null,null,2,2,2,"10.6","10.6","10.6","30.898",0,"20.054",36263000,7,"0.0346712",1,"0.845494","0.10253","sp|P21583|SCF_HUMAN;tr|S4R384|S4R384_HUMAN","sp|P21583|SCF_HUMAN;tr|S4R384|S4R384_HUMAN",1228,"P21583","SCF_HUMAN","Kit ligand",null,"KITLG"]
["21.3973","18.9758","21.9958","19.6045","21.3759","18.8532",{"$nulls":3},"GDP-mannose biosynthetic process;mannose metabolic process;protein glycosylation;protein N-linked glycosylation;protein targeting to ER","phosphomannomutase activity","cytosol;extracellular exosome;neuronal cell body;nucleus","Amino sugar and nucleotide sugar metabolism;Fructose and mannose metabolism;Metabolic pathways",null,null,10,10,9,"42.3","42.3","39.4","28.082",0,"24.056",405200000,17,"0.287191",1,"0.845086","0.711283","sp|O15305|PMM2_HUMAN;tr|H3BV55|H3BV55_HUMAN;tr|H3BPH4|H3BPH4_HUMAN;tr|H3BRM0|H3BRM0_HUMAN;tr|H3BR08|H3BR08_HUMAN;tr|H3BM92|H3BM92_HUMAN;tr|H3BV34|H3BV34_HUMAN;tr|H3BT06|H3BT06_HUMAN;tr|H3BNY9|H3BNY9_HUMAN","sp|O15305|PMM2_HUMAN;tr|H3BV55|H3BV55_HUMAN;tr|H3BPH4|H3BPH4_HUMAN;tr|H3BRM0|H3BRM0_HUMAN",361,"O15305","PMM2_HUMAN","Phosphomannomutase 2","MM 2","PMM2"]
["26.1135","25.5833","24.6484","24.1635","25.1121","24.5343",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},7,7,7,"36.2","36.2","36.2","20.51",0,"64.992",3492400000,67,"0.763105",1,"0.845056","1.65857","tr|E7EQV9|E7EQV9_HUMAN;sp|P61313|RL15_HUMAN;tr|E7ENU7|E7ENU7_HUMAN;tr|E7EX53|E7EX53_HUMAN;tr|E7ERA2|E7ERA2_HUMAN","tr|E7EQV9|E7EQV9_HUMAN;sp|P61313|RL15_HUMAN;tr|E7ENU7|E7ENU7_HUMAN;tr|E7EX53|E7EX53_HUMAN",1929,"E7EQV9","E7EQV9_HUMAN","Ribosomal protein L15 {ECO:0000256|RuleBase:RU000663}",null,"RPL15"]
["23.2703","21.4978","22.9181","21.7394","20.9791","22.4344",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},11,11,11,"58.3","58.3","58.3","33.792",0,"97.109",724070000,58,"0.544286",1,"0.844406","1.23155","tr|K7ES61|K7ES61_HUMAN;sp|Q9BYD3|RM04_HUMAN;tr|X6RAY8|X6RAY8_HUMAN;tr|K7ELQ0|K7ELQ0_HUMAN;tr|K7EKI4|K7EKI4_HUMAN;tr|K7ELF1|K7ELF1_HUMAN;tr|K7EJ73|K7EJ73_HUMAN","tr|K7ES61|K7ES61_HUMAN;sp|Q9BYD3|RM04_HUMAN;tr|X6RAY8|X6RAY8_HUMAN;tr|K7ELQ0|K7ELQ0_HUMAN",4312,"K7ES61","K7ES61_HUMAN",null,null,"MRPL4"]
["22.4712","19.832","20.3555","20.8491","19.1086","20.1691",{"$nulls":3},"mRNA splicing, via spliceosome;ribonucleoprotein complex localization;spliceosomal tri-snRNP complex assembly","ribonucleoprotein complex binding;RNA binding;snRNP binding;U4 snRNA binding;U4atac snRNA binding","Cajal body;MLL1 complex;nuclear speck;nucleoplasm;nucleus;precatalytic spliceosome;U2-type spliceosomal complex;U4 snRNP;U4/U6 x U5 tri-snRNP complex;U4atac snRNP","Spliceosome",null,null,13,13,13,"40.1","40.1","40.1","55.455",0,"94.667",683230000,79,"0.37094",1,"0.843982","0.886027","sp|Q8WWY3|PRP31_HUMAN;tr|E7EVX8|E7EVX8_HUMAN;tr|E7EU94|E7EU94_HUMAN;tr|E7ESX0|E7ESX0_HUMAN;tr|E7EN72|E7EN72_HUMAN","sp|Q8WWY3|PRP31_HUMAN;tr|E7EVX8|E7EVX8_HUMAN",3639,"Q8WWY3","PRP31_HUMAN","U4/U6 small nuclear ribonucleoprotein Prp31",null,"PRPF31"]
["19.3847","17.8784","18.4884","17.325","16.9624","18.933",{"$nulls":3},"blood coagulation;inositol phosphate metabolic process;inositol trisphosphate metabolic process;neural tube development;signal transduction","ATP binding;catalytic activity;inositol tetrakisphosphate 1-kinase activity;inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity;inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity;inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity;inositol-1,3,4-trisphosphate 5-kinase activity;inositol-1,3,4-trisphosphate 6-kinase activity;inositol-3,4,6-trisphosphate 1-kinase activity;isomerase activity;magnesium ion binding","apical plasma membrane;cytosol","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,7,7,7,28,28,28,"45.621",0,"33.002",141290000,8,"0.492329",1,"0.843698","1.12942","sp|Q13572|ITPK1_HUMAN;tr|G3V4M9|G3V4M9_HUMAN;tr|G3V588|G3V588_HUMAN;tr|G3V5A3|G3V5A3_HUMAN;tr|G3V3C0|G3V3C0_HUMAN","sp|Q13572|ITPK1_HUMAN;tr|G3V4M9|G3V4M9_HUMAN",2383,"Q13572","ITPK1_HUMAN","Inositol-tetrakisphosphate 1-kinase",null,"ITPK1"]
["20.0167","18.4653","19.2762","18.4392","17.6787","19.1155",{"$nulls":3},"antigen processing and presentation of peptide antigen via MHC class I;immune response",null,"integral component of membrane;MHC class I protein complex","Allograft rejection;Antigen processing and presentation;Autoimmune thyroid disease;Cell adhesion molecules (CAMs);Cellular senescence;Endocytosis;Epstein-Barr virus infection;Graft-versus-host disease;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Natural killer cell mediated cytotoxicity;Phagosome;Type I diabetes mellitus;Viral carcinogenesis;Viral myocarditis",null,null,6,4,4,"21.5",14,14,"40.057",0,"11.947",85020000,8,"0.619338",1,"0.841577","1.37807","tr|Q6DU44|Q6DU44_HUMAN;sp|P13747|HLAE_HUMAN","tr|Q6DU44|Q6DU44_HUMAN;sp|P13747|HLAE_HUMAN",1088,"Q6DU44","Q6DU44_HUMAN"]
["18.9501",1,"18.1555",1,"16.084","18.4969",{"$nulls":3},"chromosome segregation","metal ion binding","cytosol;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"12.5","12.5","12.5","18.355","0.00041894","4.4175",17494000,3,"0.0355324",1,"0.841573","0.104986","sp|Q9H5X1|FA96A_HUMAN;tr|H0YKV4|H0YKV4_HUMAN","sp|Q9H5X1|FA96A_HUMAN;tr|H0YKV4|H0YKV4_HUMAN",4483,"Q9H5X1","FA96A_HUMAN","MIP18 family protein FAM96A",null,"FAM96A"]
["22.6424","23.4427","22.1513","21.8321","21.7639","22.1185",{"$nulls":3},"translation","structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;nucleus;plasma membrane","Ribosome",null,null,4,4,1,"30.2","30.2","7.5","12.469",0,"30.749",1805600000,59,"1.007",1,"0.84066","2.1462","sp|Q969Q0|RL36L_HUMAN;tr|R4GN19|R4GN19_HUMAN","sp|Q969Q0|RL36L_HUMAN;tr|R4GN19|R4GN19_HUMAN",3764,"Q969Q0","RL36L_HUMAN","60S ribosomal protein L36a-like",null,"RPL36AL"]
["19.2657","18.04","18.7849","17.4921","17.081","18.9976",{"$nulls":3},"cellular localization;early endosome to recycling endosome transport;forebrain development;negative regulation of phosphatase activity","actin filament binding;actin-dependent ATPase activity;ATP binding;calcium-dependent protein binding;calmodulin binding;microfilament motor activity;protein domain specific binding","apical dendrite;axolemma;axon;basolateral plasma membrane;brush border;cytoplasmic vesicle;cytosol;endosome;extracellular exosome;myelin sheath;myosin complex;neuron projection;neuronal cell body;plasma membrane raft;smooth endoplasmic reticulum",{"$nulls":3},23,23,23,"26.9","26.9","26.9","116.2",0,"81.774",651420000,80,"0.543403",1,"0.83999","1.22982","sp|O94832|MYO1D_HUMAN;tr|J3QRN6|J3QRN6_HUMAN;tr|K7EIG7|K7EIG7_HUMAN;tr|J3KRL0|J3KRL0_HUMAN;tr|J3QRR2|J3QRR2_HUMAN","sp|O94832|MYO1D_HUMAN;tr|J3QRN6|J3QRN6_HUMAN;tr|K7EIG7|K7EIG7_HUMAN",679,"O94832","MYO1D_HUMAN","Unconventional myosin-Id",null,"MYO1D"]
["21.3364","18.5884","19.0086","19.2895","18.2866","18.8389",{"$nulls":3},"actin cytoskeleton organization;ribosomal large subunit biogenesis;ribosomal large subunit export from nucleus",null,"nucleolus;nucleus",{"$nulls":3},19,19,16,"32.3","32.3","27.8","79.87",0,"147.87",1170000000,90,"0.392599",1,"0.839444","0.930141","sp|Q9NVU7|SDA1_HUMAN;tr|E7EW05|E7EW05_HUMAN;tr|F8W8T7|F8W8T7_HUMAN","sp|Q9NVU7|SDA1_HUMAN;tr|E7EW05|E7EW05_HUMAN",4776,"Q9NVU7","SDA1_HUMAN","Protein SDA1 homolog",null,"SDAD1"]
["20.5829","17.7577","19.6986","19.6303","16.8983","18.9925",{"$nulls":3},"4-hydroxyproline catabolic process;glyoxylate metabolic process;proline catabolic process;proline catabolic process to glutamate;proline metabolic process","1-pyrroline-5-carboxylate dehydrogenase activity;aldehyde dehydrogenase (NAD) activity;electron transfer activity;identical protein binding","mitochondrial matrix","Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Metabolic pathways",null,null,12,12,12,30,30,30,"61.719",0,"72.782",236740000,35,"0.289058",1,"0.839357","0.715265","sp|P30038|AL4A1_HUMAN;tr|Q5TF55|Q5TF55_HUMAN","sp|P30038|AL4A1_HUMAN",1364,"P30038","AL4A1_HUMAN","Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","5C dehydrogenase","ALDH4A1"]
["21.1718","20.0321","19.557","20.5716","18.6047","19.0696",{"$nulls":3},"activation of MAPKK activity;cellular response to cAMP;cellular response to drug;cellular response to glucose stimulus;cellular response to nerve growth factor stimulus;establishment of endothelial barrier;liver regeneration;negative regulation of collagen biosynthetic process;negative regulation of synaptic vesicle exocytosis;nerve growth factor signaling pathway;neutrophil degranulation;positive regulation of ERK1 and ERK2 cascade;positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;positive regulation of glucose import;positive regulation of GTPase activity;positive regulation of neuron projection development;positive regulation of protein kinase activity;positive regulation of vasculogenesis;protein transport;Rap protein signal transduction;regulation of cell junction assembly;regulation of insulin secretion;response to antineoplastic agent;signal transduction","GTP binding;GTPase activity;protein complex binding;protein transporter activity;Rap guanyl-nucleotide exchange factor activity","cell junction;cytoplasm;cytosol;early endosome;extracellular exosome;guanyl-nucleotide exchange factor complex;late endosome;myelin sheath;neuron projection;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;specific granule membrane","cAMP signaling pathway;Chemokine signaling pathway;Cushing syndrome;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;MAPK signaling pathway;Neurotrophin signaling pathway;Pancreatic secretion;Platelet activation;Rap1 signaling pathway;Ras signaling pathway;Renal cell carcinoma;Tight junction",null,null,8,2,2,"46.7","14.1","14.1","20.987",0,"8.2621",137660000,4,"0.476945",1,"0.838323","1.09901","sp|P62834|RAP1A_HUMAN;tr|A0A075B6Q0|A0A075B6Q0_HUMAN","sp|P62834|RAP1A_HUMAN;tr|A0A075B6Q0|A0A075B6Q0_HUMAN",1995,"P62834","RAP1A_HUMAN","Ras-related protein Rap-1A",null,"RAP1A"]
["24.0861","23.0007","23.5249","22.9099","21.7869","23.4",{"$nulls":3},"mitochondrial ATP synthesis coupled proton transport;mitochondrial electron transport, ubiquinol to cytochrome c;response to glucagon","electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity;electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity;heme binding;metal ion binding","integral component of membrane;membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrion;nucleus","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,12,12,12,"55.4","55.4","55.4","35.422",0,"243.94",2127500000,169,"0.665431",1,"0.838322","1.46784","sp|P08574|CY1_HUMAN","sp|P08574|CY1_HUMAN",965,"P08574","CY1_HUMAN","Cytochrome c1, heme protein, mitochondrial",null,"CYC1"]
["20.2922","18.7795","19.3669","19.4403","17.695","18.7924",{"$nulls":4},"ATP binding",{"$nulls":4},3,1,1,"25.2","12.2","12.2","16.21","0.00081783","3.936",44532000,11,"0.550218",1,"0.836997","1.24316","tr|C9J2P0|C9J2P0_HUMAN;tr|H7C061|H7C061_HUMAN;tr|B7Z306|B7Z306_HUMAN;sp|P51965|UB2E1_HUMAN","tr|C9J2P0|C9J2P0_HUMAN;tr|H7C061|H7C061_HUMAN;tr|B7Z306|B7Z306_HUMAN;sp|P51965|UB2E1_HUMAN",1761,"C9J2P0","C9J2P0_HUMAN",null,null,"UBE2E1"]
["24.7228","23.5409","23.0609","22.6974","22.9303","23.2038",{"$nulls":3},"actomyosin structure organization;cellular response to mechanical stimulus;cytoskeleton organization;interleukin-12-mediated signaling pathway;neutrophil degranulation;regulation of actin filament-based process","actin binding;cadherin binding;calmodulin binding","cell-cell junction;cytoskeleton;extracellular exosome;extracellular region;focal adhesion;membrane;specific granule lumen;stress fiber;tertiary granule lumen",{"$nulls":3},14,13,13,"74.4","70.9","70.9","33.697",0,"171.97",1692200000,68,"0.74009",1,"0.831017","1.61351","sp|Q99439|CNN2_HUMAN;tr|B4DUT8|B4DUT8_HUMAN;tr|B4DDF4|B4DDF4_HUMAN;tr|A0A087X271|A0A087X271_HUMAN;tr|A0A087X1X5|A0A087X1X5_HUMAN;tr|H3BVI6|H3BVI6_HUMAN;tr|K7ES69|K7ES69_HUMAN;tr|H3BQH0|H3BQH0_HUMAN;tr|A0A087WV51|A0A087WV51_HUMAN;tr|U3KPS3|U3KPS3_HUMAN","sp|Q99439|CNN2_HUMAN;tr|B4DUT8|B4DUT8_HUMAN;tr|B4DDF4|B4DDF4_HUMAN;tr|A0A087X271|A0A087X271_HUMAN;tr|A0A087X1X5|A0A087X1X5_HUMAN;tr|H3BVI6|H3BVI6_HUMAN;tr|K7ES69|K7ES69_HUMAN",4060,"Q99439","CNN2_HUMAN","Calponin-2",null,"CNN2"]
["19.9446","20.8356","19.71","18.3258","20.2924","19.3885",{"$nulls":3},"viral process","RNA binding","nucleolus;nucleus",{"$nulls":3},15,15,15,55,55,55,"40.235",0,"143.04",1077100000,72,"0.552298",1,"0.827855","1.24723","sp|Q9H6F5|CCD86_HUMAN;tr|H0YG79|H0YG79_HUMAN","sp|Q9H6F5|CCD86_HUMAN",4486,"Q9H6F5","CCD86_HUMAN","Coiled-coil domain-containing protein 86",null,"CCDC86"]
["20.1817","20.4472","17.4508","18.674","19.2547","17.668",{"$nulls":4},"oxidoreductase activity","mitochondrion;nucleoplasm",{"$nulls":3},5,5,5,"25.8","25.8","25.8","29.012",0,"32.715",224970000,19,"0.318723",1,"0.827666","0.777964","tr|E9PCG9|E9PCG9_HUMAN;sp|Q02338|BDH_HUMAN;tr|C9K0G7|C9K0G7_HUMAN;tr|H7C2W1|H7C2W1_HUMAN;tr|C9JM78|C9JM78_HUMAN;tr|C9JQ90|C9JQ90_HUMAN;tr|A0A0G2JRX6|A0A0G2JRX6_HUMAN","tr|E9PCG9|E9PCG9_HUMAN;sp|Q02338|BDH_HUMAN;tr|C9K0G7|C9K0G7_HUMAN;tr|H7C2W1|H7C2W1_HUMAN;tr|C9JM78|C9JM78_HUMAN;tr|C9JQ90|C9JQ90_HUMAN;tr|A0A0G2JRX6|A0A0G2JRX6_HUMAN",2157,"E9PCG9","E9PCG9_HUMAN",null,null,"BDH1"]
["16.5112","15.9029","16.6639","14.7647","15.675","16.156",{"$nulls":3},"BMP signaling pathway;endosomal transport;protein targeting to lysosome;regulation of endocytosis;signal transduction;vesicle organization","1-phosphatidylinositol binding;metal ion binding;phosphatidylinositol-3,4,5-trisphosphate binding;protein transporter activity","cytosol;early endosome;early endosome membrane;intracellular membrane-bounded organelle","Endocytosis;TGF-beta signaling pathway",null,null,4,4,4,"3.9","3.9","3.9","168.9",0,"9.0666",45720000,7,"0.815828",1,"0.827403","1.76224","sp|Q7Z3T8|ZFY16_HUMAN","sp|Q7Z3T8|ZFY16_HUMAN",3157,"Q7Z3T8","ZFY16_HUMAN","Zinc finger FYVE domain-containing protein 16",null,"ZFYVE16"]
["21.3259","20.0731","20.6414","20.3337","19.4844","19.7409",{"$nulls":3},"proteolysis","enzyme activator activity;metal ion binding;metalloendopeptidase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},23,23,23,"28.8","28.8","28.8","117.41",0,"74.099",616090000,62,"0.873155",1,"0.827124","1.87586","sp|Q5JRX3|PREP_HUMAN;tr|A0A0A0MRX9|A0A0A0MRX9_HUMAN;tr|H0Y7L7|H0Y7L7_HUMAN;tr|B1APQ0|B1APQ0_HUMAN;tr|H0Y4F7|H0Y4F7_HUMAN;tr|B1APQ1|B1APQ1_HUMAN","sp|Q5JRX3|PREP_HUMAN;tr|A0A0A0MRX9|A0A0A0MRX9_HUMAN",2822,"Q5JRX3","PREP_HUMAN","Presequence protease, mitochondrial","PreP","PITRM1"]
["21.0005","19.9315","20.318","19.5948","19.1921","19.9826",{"$nulls":3},"'de novo' pyrimidine nucleobase biosynthetic process;'de novo' UMP biosynthetic process;female pregnancy;lactation;positive regulation of apoptotic process;pyrimidine nucleoside biosynthetic process;regulation of mitochondrial fission;response to caffeine;response to drug;response to L-arginine;response to starvation","dihydroorotate dehydrogenase activity;drug binding;FMN binding;ubiquinone binding","cytosol;integral component of membrane;mitochondrial inner membrane;mitochondrion;neuronal cell body;nucleoplasm","Metabolic pathways;Pyrimidine metabolism",null,null,9,9,9,"33.7","33.7","33.7","42.867",0,"38.915",268840000,27,"1.00241",1,"0.826862","2.13678","sp|Q02127|PYRD_HUMAN;tr|I3NI32|I3NI32_HUMAN;tr|J3QRQ3|J3QRQ3_HUMAN;tr|I3L449|I3L449_HUMAN;tr|J3QRJ4|J3QRJ4_HUMAN","sp|Q02127|PYRD_HUMAN;tr|I3NI32|I3NI32_HUMAN",2153,"Q02127","PYRD_HUMAN","Dihydroorotate dehydrogenase (quinone), mitochondrial","HOdehase","DHODH"]
["22.4841","21.6735","22.0017","21.6417","20.6776","21.363",{"$nulls":3},"carnitine metabolic process;carnitine shuttle;cellular response to fatty acid;circadian rhythm;eating behavior;epithelial cell differentiation;fatty acid beta-oxidation;glucose metabolic process;long-chain fatty acid metabolic process;positive regulation of fatty acid beta-oxidation;protein homooligomerization;regulation of insulin secretion;regulation of lipid metabolic process;response to drug;response to organic cyclic compound;triglyceride metabolic process","carnitine O-palmitoyltransferase activity;identical protein binding;palmitoleoyltransferase activity","integral component of mitochondrial outer membrane;membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion","Adipocytokine signaling pathway;AMPK signaling pathway;Fatty acid degradation;Fatty acid metabolism;Glucagon signaling pathway;Insulin resistance;PPAR signaling pathway;Thermogenesis",null,null,24,24,24,"37.3","37.3","37.3","88.367",0,"176.14",2493700000,168,"1.04617",1,"0.82568","2.22696","sp|P50416|CPT1A_HUMAN;tr|H3BP22|H3BP22_HUMAN;tr|H3BUV7|H3BUV7_HUMAN;tr|H3BMD2|H3BMD2_HUMAN;tr|H3BUJ0|H3BUJ0_HUMAN","sp|P50416|CPT1A_HUMAN",1706,"P50416","CPT1A_HUMAN","Carnitine O-palmitoyltransferase 1, liver isoform","PT1-L","CPT1A"]
["20.6217","19.1649","20.6095","19.603","18.9078","19.4102",{"$nulls":3},"apoptotic process;central nervous system development;Fc-gamma receptor signaling pathway involved in phagocytosis;positive regulation of actin filament polymerization;positive regulation of Arp2/3 complex-mediated actin nucleation;positive regulation of lamellipodium assembly;Rac protein signal transduction;vascular endothelial growth factor receptor signaling pathway;viral process","protein complex binding","cytosol;extracellular exosome;filamentous actin;focal adhesion;integral component of membrane;lamellipodium;lamellipodium membrane;ruffle;SCAR complex","Regulation of actin cytoskeleton",null,null,12,12,12,"12.1","12.1","12.1","128.79",0,"64.17",674540000,64,"0.716894",1,"0.825027","1.56818","sp|Q9Y2A7|NCKP1_HUMAN","sp|Q9Y2A7|NCKP1_HUMAN",5216,"Q9Y2A7","NCKP1_HUMAN","Nck-associated protein 1","AP 1","NCKAP1"]
["21.3568","20.4448","20.5574","20.2334","19.8846","19.7685",{"$nulls":3},"cell adhesion","metal ion binding","cytosol;focal adhesion;nucleus;plasma membrane",{"$nulls":3},13,13,13,"35.6","35.6","35.6","65.746",0,"61.688",337130000,50,"1.21296",1,"0.82417","2.58135","sp|Q93052|LPP_HUMAN;tr|A0A087WZF1|A0A087WZF1_HUMAN;tr|C9JUT4|C9JUT4_HUMAN;tr|C9JXK9|C9JXK9_HUMAN;tr|C9JE51|C9JE51_HUMAN;tr|C9J2R5|C9J2R5_HUMAN;tr|C9JIY7|C9JIY7_HUMAN;tr|C9JT42|C9JT42_HUMAN;tr|C9J3U9|C9J3U9_HUMAN;tr|C9J1K7|C9J1K7_HUMAN;tr|C9J5C8|C9J5C8_HUMAN;tr|C9J4E3|C9J4E3_HUMAN","sp|Q93052|LPP_HUMAN;tr|A0A087WZF1|A0A087WZF1_HUMAN;tr|C9JUT4|C9JUT4_HUMAN;tr|C9JXK9|C9JXK9_HUMAN",3753,"Q93052","LPP_HUMAN","Lipoma-preferred partner",null,"LPP"]
["17.3092","15.7716","16.9714","15.4003","15.0147","17.1657",{"$nulls":3},"blastocyst development;cerebral cortex development;generation of catalytic spliceosome for first transesterification step;mRNA splicing, via spliceosome;transcription, DNA-templated;transcription-coupled nucleotide-excision repair",null,"catalytic step 1 spliceosome;catalytic step 2 spliceosome;membrane;nucleoplasm;nucleus;post-mRNA release spliceosomal complex;prespliceosome;Prp19 complex","Spliceosome",null,null,5,5,5,"8.1","8.1","8.1","100.01",0,"12.079",48728000,8,"0.435805",1,"0.82388","1.01715","sp|Q9HCS7|SYF1_HUMAN","sp|Q9HCS7|SYF1_HUMAN",4602,"Q9HCS7","SYF1_HUMAN","Pre-mRNA-splicing factor SYF1",null,"XAB2"]
["18.4904",1,"20.0544",1,"17.3788","18.6966",{"$nulls":3},"alcohol metabolic process;cellular ketone metabolic process;oxidation-reduction process;protein tetramerization;steroid metabolic process","3-keto sterol reductase activity;alcohol dehydrogenase [NAD(P)+] activity;carbonyl reductase (NADPH) activity;NADP-retinol dehydrogenase activity;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;receptor binding","endoplasmic reticulum membrane;extracellular exosome;mitochondrion;nucleus;peroxisomal membrane;peroxisome","Metabolic pathways;Peroxisome;Retinol metabolism",null,null,4,4,4,"11.2","11.2","11.2","29.537",0,"7.7654",33741000,5,"0.0332935",1,"0.823132","0.0985943","sp|Q9BTZ2|DHRS4_HUMAN;tr|F5GWZ1|F5GWZ1_HUMAN;sp|P0CG22|DR4L1_HUMAN","sp|Q9BTZ2|DHRS4_HUMAN;tr|F5GWZ1|F5GWZ1_HUMAN",4218,"Q9BTZ2","DHRS4_HUMAN","Dehydrogenase/reductase SDR family member 4",null,"DHRS4"]
["28.4174","26.9063","27.7482","27.3529","26.082","27.1683",{"$nulls":3},"angiogenesis;ATP biosynthetic process;cristae formation;generation of precursor metabolites and energy;lipid metabolic process;mitochondrial ATP synthesis coupled proton transport;mitochondrion organization;negative regulation of cell adhesion involved in substrate-bound cell migration;osteoblast differentiation;positive regulation of blood vessel endothelial cell migration;proton transport;regulation of intracellular pH","angiostatin binding;ATP binding;MHC class I protein binding;proton-transporting ATP synthase activity, rotational mechanism;proton-transporting ATPase activity, rotational mechanism;transmembrane transporter activity;transporter activity","cell surface;extracellular exosome;extracellular matrix;membrane;mitochondrial matrix;mitochondrial membrane;mitochondrial nucleoid;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase, catalytic core;mitochondrion;myelin sheath;nucleus;plasma membrane;proton-transporting ATP synthase complex","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,26,26,26,"70.9","70.9","70.9","56.559",0,"323.31",46899000000,913,"0.62775",1,"0.822948","1.39445","sp|P06576|ATPB_HUMAN;tr|H0YH81|H0YH81_HUMAN;tr|F8W079|F8W079_HUMAN;tr|F8W0P7|F8W0P7_HUMAN;tr|H0YI37|H0YI37_HUMAN","sp|P06576|ATPB_HUMAN;tr|H0YH81|H0YH81_HUMAN;tr|F8W079|F8W079_HUMAN",914,"P06576","ATPB_HUMAN","ATP synthase subunit beta, mitochondrial",null,"ATP5B"]
["21.7312","21.3576","21.1712","19.7332","20.9401","21.1202",{"$nulls":3},"defense response to virus;DNA deamination;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;histone mRNA catabolic process;maturation of 5.8S rRNA;nuclear mRNA surveillance;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';polyadenylation-dependent snoRNA 3'-end processing;positive regulation of cell growth;regulation of mRNA stability;rRNA 3'-end processing;rRNA catabolic process;rRNA processing;U4 snRNA 3'-end processing","3'-5'-exoribonuclease activity;AU-rich element binding","cytoplasm;cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);intermediate filament cytoskeleton;nuclear exosome (RNase complex);nucleolus;nucleoplasm;nucleus;transcriptionally active chromatin","RNA degradation",null,null,7,7,7,"33.5","33.5","33.5","26.383",0,"23.489",197130000,18,"0.817855",1,"0.822196","1.76624","sp|Q9NPD3|EXOS4_HUMAN;tr|E9PI41|E9PI41_HUMAN;tr|E9PPI9|E9PPI9_HUMAN","sp|Q9NPD3|EXOS4_HUMAN;tr|E9PI41|E9PI41_HUMAN",4632,"Q9NPD3","EXOS4_HUMAN","Exosome complex component RRP41",null,"EXOSC4"]
["17.154","18.915","19.9593","17.2916","17.5472","18.7243",{"$nulls":5},"integral component of membrane",{"$nulls":3},4,4,4,"22.4","22.4","22.4","30.292",0,"23.211",116620000,13,"0.369792",1,"0.821727","0.883679","tr|K7EK00|K7EK00_HUMAN;sp|Q96ND0|F210A_HUMAN;tr|K7EPG9|K7EPG9_HUMAN;tr|K7ERQ2|K7ERQ2_HUMAN","tr|K7EK00|K7EK00_HUMAN;sp|Q96ND0|F210A_HUMAN",3984,"K7EK00","K7EK00_HUMAN",null,null,"FAM210A"]
["19.7113","20.2357","19.357","18.9863","18.5559","19.2976",{"$nulls":3},"cristae formation",null,"MICOS complex;mitochondrion",{"$nulls":3},8,8,8,"42.2","42.2","42.2","29.205",0,"25.179",387900000,41,"1.15736",1,"0.821408","2.46115","tr|A0A087WYF7|A0A087WYF7_HUMAN;sp|Q6UXV4|MIC27_HUMAN;tr|A0A087WUX8|A0A087WUX8_HUMAN","tr|A0A087WYF7|A0A087WYF7_HUMAN;sp|Q6UXV4|MIC27_HUMAN;tr|A0A087WUX8|A0A087WUX8_HUMAN",3064,"A0A087WYF7","A0A087WYF7_HUMAN","MICOS complex subunit {ECO:0000256|RuleBase:RU363021}",null,"APOOL"]
["22.3489","21.5299","21.1809","21.2685","20.1201","21.2076",{"$nulls":4},"pyridoxal phosphate binding","cytoplasm;extracellular exosome;intracellular;mitochondrion",{"$nulls":3},10,10,10,"42.2","42.2","42.2","30.344",0,"52.492",451170000,33,"0.740139",1,"0.821194","1.6136","sp|O94903|PROSC_HUMAN;tr|E5RFX7|E5RFX7_HUMAN;tr|E5RG77|E5RG77_HUMAN;tr|H0YBG2|H0YBG2_HUMAN;tr|E5RFZ4|E5RFZ4_HUMAN","sp|O94903|PROSC_HUMAN;tr|E5RFX7|E5RFX7_HUMAN;tr|E5RG77|E5RG77_HUMAN",689,"O94903","PLPHP_HUMAN","Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225}","LP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225}"]
["21.9151","20.7893","21.1377","21.211","19.1845","20.9895",{"$nulls":3},"actin filament capping;axon guidance;common-partner SMAD protein phosphorylation;ER to Golgi vesicle-mediated transport;Golgi to plasma membrane protein transport;MAPK cascade;membrane assembly;mitotic cytokinesis;plasma membrane organization;positive regulation of interleukin-2 secretion;positive regulation of protein localization to plasma membrane;protein localization to plasma membrane;regulation of protein localization to plasma membrane;SMAD protein import into nucleus","actin binding;ankyrin binding;cadherin binding;calmodulin binding;GTPase binding;phospholipid binding;protein complex binding;Ras guanyl-nucleotide exchange factor activity;RNA binding;structural constituent of cytoskeleton","axolemma;cuticular plate;cytoplasm;cytosol;extracellular exosome;M band;nucleolus;postsynaptic density;protein complex;spectrin;spectrin-associated cytoskeleton",{"$nulls":3},77,77,72,"43.7","43.7","41.5","274.61",0,"323.31",3158500000,273,"0.494126",1,"0.819052","1.13297","sp|Q01082|SPTB2_HUMAN;tr|A0A087WUZ3|A0A087WUZ3_HUMAN;tr|F8W6C1|F8W6C1_HUMAN;tr|E9PJZ2|E9PJZ2_HUMAN;sp|P11277|SPTB1_HUMAN","sp|Q01082|SPTB2_HUMAN;tr|A0A087WUZ3|A0A087WUZ3_HUMAN",2128,"Q01082","SPTB2_HUMAN","Spectrin beta chain, non-erythrocytic 1",null,"SPTBN1"]
["20.497","19.058","19.3362","18.7216","17.8085","19.9046",{"$nulls":3},"phosphatidylcholine acyl-chain remodeling;phosphatidylethanolamine acyl-chain remodeling;phosphatidylserine acyl-chain remodeling;phospholipid biosynthetic process;regulation of plasma lipoprotein particle levels","1-acylglycerol-3-phosphate O-acyltransferase activity;1-acylglycerophosphocholine O-acyltransferase activity;2-acylglycerol-3-phosphate O-acyltransferase activity","endoplasmic reticulum membrane;integral component of membrane;membrane","Ferroptosis;Glycerophospholipid metabolism",null,null,3,3,3,"9.9","9.9","9.9","56.034",0,"45.065",103340000,12,"0.473393",1,"0.818851","1.09197","sp|Q6P1A2|MBOA5_HUMAN;tr|F5H0M4|F5H0M4_HUMAN;tr|F5H680|F5H680_HUMAN;tr|F5H7K7|F5H7K7_HUMAN;tr|B7Z3N5|B7Z3N5_HUMAN;tr|F5GYT3|F5GYT3_HUMAN","sp|Q6P1A2|MBOA5_HUMAN;tr|F5H0M4|F5H0M4_HUMAN",2995,"Q6P1A2","MBOA5_HUMAN","Lysophospholipid acyltransferase 5","PLAT 5","LPCAT3"]
["24.0902","22.3535","23.3768","23.1978","21.4496","22.7169",{"$nulls":3},"cardiolipin acyl-chain remodeling;fatty acid beta-oxidation;response to drug;response to insulin","3-hydroxyacyl-CoA dehydrogenase activity;acetyl-CoA C-acetyltransferase activity;enoyl-CoA hydratase activity;fatty-acyl-CoA binding;long-chain-3-hydroxyacyl-CoA dehydrogenase activity;long-chain-enoyl-CoA hydratase activity;NAD binding;protein complex binding","extracellular matrix;mitochondrial fatty acid beta-oxidation multienzyme complex;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrion","beta-Alanine metabolism;Butanoate metabolism;Carbon metabolism;Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Lysine degradation;Metabolic pathways;Propanoate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,36,36,36,"60.2","60.2","60.2","82.999",0,"323.31",14459000000,671,"0.492112",1,"0.818706","1.12899","sp|P40939|ECHA_HUMAN;tr|H0YFD6|H0YFD6_HUMAN","sp|P40939|ECHA_HUMAN",1527,"P40939","ECHA_HUMAN","Trifunctional enzyme subunit alpha, mitochondrial",null,"HADHA"]
["19.9317","20.0475","19.2989","18.9728","18.7548","19.0966",{"$nulls":3},"mitochondrial respiratory chain complex I assembly;mitochondrial respiratory chain complex IV assembly;protein import into mitochondrial matrix",null,"integral component of membrane;mitochondrial inner membrane presequence translocase complex",{"$nulls":3},6,6,6,"26.6","26.6","26.6","28.202",0,"14.543",354760000,34,"1.49544",1,"0.81797","3.23063","sp|Q9BVV7|TIM21_HUMAN;tr|J3QRI1|J3QRI1_HUMAN;tr|J3KRJ3|J3KRJ3_HUMAN","sp|Q9BVV7|TIM21_HUMAN;tr|J3QRI1|J3QRI1_HUMAN",4264,"Q9BVV7","TIM21_HUMAN","Mitochondrial import inner membrane translocase subunit Tim21",null,"TIMM21"]
["23.1177","22.0756","22.7931","21.5152","21.7908","22.2266",{"$nulls":3},"2-oxoglutarate metabolic process;carbohydrate metabolic process;glyoxylate cycle;isocitrate metabolic process;mitochondrion organization;NADP biosynthetic process;negative regulation of glial cell migration;negative regulation of glial cell proliferation;negative regulation of matrix metallopeptidase secretion;tricarboxylic acid cycle","isocitrate dehydrogenase (NADP+) activity;magnesium ion binding;NAD binding","cytosol;extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;peroxisome","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Glutathione metabolism;Metabolic pathways;Peroxisome",null,null,18,17,17,"47.8","45.8","45.8","50.909",0,"145.86",1388600000,83,"1.03532",1,"0.817963","2.2045","sp|P48735|IDHP_HUMAN;tr|H0YL11|H0YL11_HUMAN","sp|P48735|IDHP_HUMAN;tr|H0YL11|H0YL11_HUMAN",1638,"P48735","IDHP_HUMAN","Isocitrate dehydrogenase [NADP], mitochondrial","DH","IDH2"]
["20.2398","19.3502","20.178","19.6908","17.3817","20.2425",{"$nulls":5},"integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},37,4,1,"64.2","9.7",2,"73.253",0,"45.027",340420000,24,"0.371336",1,"0.81766","0.886839","tr|C9J406|C9J406_HUMAN;tr|H7C463|H7C463_HUMAN","tr|C9J406|C9J406_HUMAN;tr|H7C463|H7C463_HUMAN",5486,"C9J406","C9J406_HUMAN","MICOS complex subunit MIC60 {ECO:0000256|RuleBase:RU363000}",null,"IMMT"]
["23.5397","23.3789","21.1847","22.4114","21.9961","21.2433",{"$nulls":3},"hydrogen ion transmembrane transport;mitochondrial electron transport, cytochrome c to oxygen;mitochondrial electron transport, NADH to ubiquinone","NADH dehydrogenase (ubiquinone) activity;protein complex binding","extracellular exosome;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrial respiratory chain complex IV;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,4,4,4,"46.9","46.9","46.9","9.3697",0,"11.273",357100000,13,"0.417969",1,"0.817481","0.981377","sp|O00483|NDUA4_HUMAN","sp|O00483|NDUA4_HUMAN",245,"O00483","NDUA4_HUMAN","Cytochrome c oxidase subunit NDUFA4",null,"NDUFA4"]
["21.5804","19.9126","20.3549","20.1644","19.106","20.1284",{"$nulls":3},"protein deubiquitination;spliceosomal complex assembly","thiol-dependent ubiquitinyl hydrolase activity;zinc ion binding",{"$nulls":4},16,16,16,"35.8","35.8","35.8","62.043",0,"115.31",1271200000,135,"0.601619",1,"0.816379","1.34354","tr|B9A018|B9A018_HUMAN;sp|Q53GS9|SNUT2_HUMAN;tr|A0A087X1B2|A0A087X1B2_HUMAN;tr|F8WC91|F8WC91_HUMAN;tr|A0A087WW31|A0A087WW31_HUMAN;tr|C9JIU2|C9JIU2_HUMAN;tr|C9J0X5|C9J0X5_HUMAN","tr|B9A018|B9A018_HUMAN;sp|Q53GS9|SNUT2_HUMAN;tr|A0A087X1B2|A0A087X1B2_HUMAN",2780,"B9A018","B9A018_HUMAN",null,null,"USP39"]
["22.675","19.17","20.8392","22.3205","18.7939","19.121",{"$nulls":3},"activation of NF-kappaB-inducing kinase activity;COP9 signalosome assembly;negative regulation of cell proliferation;nucleotide-excision repair, DNA damage recognition;post-translational protein modification;protein deneddylation;transcription-coupled nucleotide-excision repair",null,"COP9 signalosome;cytosol;extracellular exosome;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},5,5,5,"50.7","50.7","50.7","23.225",0,"58.988",161320000,19,"0.20883",1,"0.816233","0.539361","sp|Q99627|CSN8_HUMAN;tr|E9PGT6|E9PGT6_HUMAN;tr|H7C3S9|H7C3S9_HUMAN","sp|Q99627|CSN8_HUMAN;tr|E9PGT6|E9PGT6_HUMAN",4091,"Q99627","CSN8_HUMAN","COP9 signalosome complex subunit 8","GN8;ignalosome subunit 8","COPS8"]
["19.5764","18.9499","18.449","18.3566","18.0728","18.0977",{"$nulls":3},"nervous system development","heparin binding;serine-type endopeptidase inhibitor activity;transition metal ion binding","integral component of membrane",{"$nulls":3},7,7,7,"14.6","14.6","14.6","80.832",0,"56.266",146490000,17,"1.13371",1,"0.816069","2.41069","tr|E9PG40|E9PG40_HUMAN;sp|P05067|A4_HUMAN;tr|A0A0A0MRG2|A0A0A0MRG2_HUMAN;tr|H7C0V9|H7C0V9_HUMAN;tr|H7C2L2|H7C2L2_HUMAN","tr|E9PG40|E9PG40_HUMAN;sp|P05067|A4_HUMAN;tr|A0A0A0MRG2|A0A0A0MRG2_HUMAN;tr|H7C0V9|H7C0V9_HUMAN",889,"E9PG40","E9PG40_HUMAN",null,null,"APP"]
["25.8128","24.3363","25.2143","24.9953","23.6611","24.2636",{"$nulls":3},"cell proliferation;IRE1-mediated unfolded protein response;negative regulation of transcription from RNA polymerase II promoter;signal transduction;transcription, DNA-templated","DNA binding;growth factor activity;heparin binding;nucleotide binding;RNA binding;RNA polymerase II transcription corepressor activity;transcription corepressor binding","cytoplasm;extracellular matrix;extracellular region;extracellular space;nucleoplasm;transcriptional repressor complex",{"$nulls":3},15,14,14,"64.6","61.2","61.2","26.788",0,"323.31",4666700000,167,"0.636829",1,"0.814461","1.41214","sp|P51858|HDGF_HUMAN","sp|P51858|HDGF_HUMAN",1758,"P51858","HDGF_HUMAN","Hepatoma-derived growth factor","DGF","HDGF"]
["21.5512","20.7646","21.8249","19.4815","20.5552","21.6647",{"$nulls":3},"bicellular tight junction assembly;cellular response to insulin stimulus;cortical actin cytoskeleton organization;endocytic recycling;endosomal transport;endothelial cell chemotaxis;establishment of Sertoli cell barrier;neuron projection development;post-translational protein modification;protein kinase A signaling;protein localization to cell leading edge;protein localization to plasma membrane;protein transport;trans-Golgi network to recycling endosome transport","GTP binding;GTPase activity;protein kinase A catalytic subunit binding","bicellular tight junction;cell junction;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;endocytic vesicle;extracellular exosome;insulin-responsive compartment;lamellipodium;lateral plasma membrane;neuron projection;plasma membrane;recycling endosome;recycling endosome membrane;trans-Golgi network","Tight junction",null,null,8,6,5,"42.9",34,30,"22.774",0,"23.204",417160000,32,"0.503763",1,"0.813119","1.15197","sp|P51153|RAB13_HUMAN;tr|A0A087WWB9|A0A087WWB9_HUMAN","sp|P51153|RAB13_HUMAN",1733,"P51153","RAB13_HUMAN","Ras-related protein Rab-13",null,"RAB13"]
["21.8259","20.2441","21.5807","21.1533","19.0684","20.9901",{"$nulls":3},"innate immune response;toll-like receptor signaling pathway","receptor binding","endoplasmic reticulum lumen",{"$nulls":3},5,5,5,"21.2","21.2","21.2","30.748",0,"32.468",298110000,22,"0.416753",1,"0.812997","0.97893","sp|Q9BT09|CNPY3_HUMAN;tr|A0A0C4DFY8|A0A0C4DFY8_HUMAN","sp|Q9BT09|CNPY3_HUMAN",4193,"Q9BT09","CNPY3_HUMAN","Protein canopy homolog 3",null,"CNPY3"]
["20.2674","17.3619","18.7464","18.6397","17.6644","17.6382",{"$nulls":3},"urea cycle","identical protein binding","cytosol;nucleus;perinuclear region of cytoplasm",{"$nulls":3},6,6,6,"24.1","24.1","24.1","33.344",0,"16.376",87619000,8,"0.377675",1,"0.811113","0.899786","sp|Q9HBL8|NMRL1_HUMAN;tr|I3L543|I3L543_HUMAN;tr|I3L0Y6|I3L0Y6_HUMAN;tr|I3L3I6|I3L3I6_HUMAN;tr|I3L3Z0|I3L3Z0_HUMAN;tr|I3L1Y8|I3L1Y8_HUMAN","sp|Q9HBL8|NMRL1_HUMAN;tr|I3L543|I3L543_HUMAN;tr|I3L0Y6|I3L0Y6_HUMAN;tr|I3L3I6|I3L3I6_HUMAN",4576,"Q9HBL8","NMRL1_HUMAN","NmrA-like family domain-containing protein 1",null,"NMRAL1"]
["21.8731","18.9778","21.0917","20.517","17.9164","21.078",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;response to hydrogen peroxide;response to hypoxia;response to organonitrogen compound","NADH dehydrogenase (ubiquinone) activity","integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I;neuron projection","Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,4,4,4,"12.4","12.4","12.4","67.026",0,"28.149",165500000,21,"0.246014",1,"0.810399","0.622192","sp|P03915|NU5M_HUMAN","sp|P03915|NU5M_HUMAN",859,"P03915","NU5M_HUMAN","NADH-ubiquinone oxidoreductase chain 5",null,"MT-ND5"]
["16.3968","14.9716","15.1678","16.1487","13.8071","14.1505",{"$nulls":3},"Golgi to endosome transport;mitochondrion organization;negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization",null,"cytoplasm;cytosol;extracellular exosome;mitochondrial outer membrane",{"$nulls":3},14,14,14,5,5,5,"422.39",0,"30.84",103730000,21,"0.400806",1,"0.80998","0.946764","sp|Q709C8|VP13C_HUMAN","sp|Q709C8|VP13C_HUMAN",3094,"Q709C8","VP13C_HUMAN","Vacuolar protein sorting-associated protein 13C",null,"VPS13C"]
["25.6215","23.7612","24.6524","24.7197","22.4551","24.4309",{"$nulls":3},"ion transport;macroautophagy;protein import into mitochondrial matrix;protein targeting to mitochondrion","porin activity;protein channel activity;protein transmembrane transporter activity","cytosol;extracellular exosome;integral component of membrane;integral component of mitochondrial outer membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrial outer membrane translocase complex;mitochondrion;pore complex","Amyotrophic lateral sclerosis (ALS)",null,null,9,9,9,"42.1","42.1","42.1","37.893",0,"280.16",2024400000,67,"0.381839",1,"0.809835","0.908272","sp|O96008|TOM40_HUMAN;tr|K7EJ57|K7EJ57_HUMAN;tr|K7EKG4|K7EKG4_HUMAN","sp|O96008|TOM40_HUMAN;tr|K7EJ57|K7EJ57_HUMAN",813,"O96008","TOM40_HUMAN","Mitochondrial import receptor subunit TOM40 homolog",null,"TOMM40"]
["19.405","18.2267","20.6815","19.3846","17.6039","18.9075",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;protein localization to pericentriolar material","DNA binding transcription factor activity;RNA binding;sequence-specific DNA binding","cis-Golgi network;endoplasmic reticulum-Golgi intermediate compartment;Golgi apparatus;Golgi membrane;Golgi stack;integral component of membrane;membrane",{"$nulls":3},78,78,77,"34.2","34.2","33.9","376.01",0,"323.31",2069000000,237,"0.382198",1,"0.805723","0.909003","sp|Q14789|GOGB1_HUMAN;tr|E7EU81|E7EU81_HUMAN;tr|H0Y867|H0Y867_HUMAN;tr|H7C5I7|H7C5I7_HUMAN;REV__sp|Q8N884|CGAS_HUMAN","sp|Q14789|GOGB1_HUMAN;tr|E7EU81|E7EU81_HUMAN",2507,"Q14789","GOGB1_HUMAN","Golgin subfamily B member 1",null,"GOLGB1"]
["25.5633","24.0571","24.1541","24.4565","23.0778","23.8231",{"$nulls":3},"histone mRNA metabolic process;mRNA splicing, via spliceosome;nuclear import;protein methylation;RNA splicing;spliceosomal complex assembly;spliceosomal snRNP assembly;termination of RNA polymerase II transcription","enzyme binding;histone pre-mRNA DCP binding;RNA binding;telomerase RNA binding;U1 snRNP binding;U2 snRNA binding;U7 snRNA binding","catalytic step 2 spliceosome;commitment complex;cytosol;extracellular exosome;methylosome;nuclear body;nucleoplasm;pICln-Sm protein complex;precatalytic spliceosome;prespliceosome;small nuclear ribonucleoprotein complex;SMN-Sm protein complex;spliceosomal complex;spliceosomal tri-snRNP complex;U1 snRNP;U12-type spliceosomal complex;U2 snRNP;U4 snRNP;U5 snRNP;U7 snRNP","Spliceosome;Systemic lupus erythematosus",null,null,5,5,5,"53.2","53.2","53.2","13.916",0,"82.904",1884700000,78,"0.569565",1,"0.805701","1.28099","sp|P62318|SMD3_HUMAN;tr|H3BT13|H3BT13_HUMAN","sp|P62318|SMD3_HUMAN;tr|H3BT13|H3BT13_HUMAN",1976,"P62318","SMD3_HUMAN","Small nuclear ribonucleoprotein Sm D3","m-D3","SNRPD3"]
["20.6779","20.8441","19.8812","19.9241","20.4576","18.6049",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;ER to Golgi vesicle-mediated transport",null,"centrosome;condensed chromosome kinetochore;cytosol;dynactin complex","Vasopressin-regulated water reabsorption",null,null,2,2,2,"14.7","14.7","14.7","20.747",0,"6.6799",81562000,3,"0.572815",1,"0.805493","1.28734","sp|O00399|DCTN6_HUMAN;tr|E5RK00|E5RK00_HUMAN","sp|O00399|DCTN6_HUMAN;tr|E5RK00|E5RK00_HUMAN",228,"O00399","DCTN6_HUMAN","Dynactin subunit 6",null,"DCTN6"]
["18.3295","16.1278","17.3187","17.0881","15.0732","17.2026",{"$nulls":3},"DNA methylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;regulation of RNA polymerase II transcriptional preinitiation complex assembly;transcription, DNA-templated;viral process","ATPase activity;transcription corepressor activity","cytosol;nuclear body;nucleoplasm;nucleus;transcription factor complex",{"$nulls":3},6,6,6,"7.8","7.8","7.8","136.39",0,"17.854",78817000,10,"0.356102",1,"0.804003","0.855584","sp|Q6VMQ6|MCAF1_HUMAN;tr|A8MV73|A8MV73_HUMAN;tr|F5GYR7|F5GYR7_HUMAN;tr|F5H592|F5H592_HUMAN","sp|Q6VMQ6|MCAF1_HUMAN",3065,"Q6VMQ6","MCAF1_HUMAN","Activating transcription factor 7-interacting protein 1",null,"ATF7IP"]
["20.1153","17.6265","19.6168","18.5712","18.0582","18.318",{"$nulls":3},"Cajal body organization",{"$nulls":5},5,5,5,"17.9","17.9","17.9","39.079",0,"10.035",106270000,8,"0.44608",1,"0.803726","1.03767","tr|E9PMJ2|E9PMJ2_HUMAN;tr|J3KP39|J3KP39_HUMAN;sp|Q9BPY3|F118B_HUMAN;tr|G3V179|G3V179_HUMAN;tr|E9PMW3|E9PMW3_HUMAN;tr|E9PIM5|E9PIM5_HUMAN","tr|E9PMJ2|E9PMJ2_HUMAN;tr|J3KP39|J3KP39_HUMAN;sp|Q9BPY3|F118B_HUMAN;tr|G3V179|G3V179_HUMAN",4131,"E9PMJ2","E9PMJ2_HUMAN",null,null,"FAM118B"]
["20.9516","20.4468","18.8619","20.0414","19.5443","18.2636",{"$nulls":3},"genitalia development;protein folding;protein targeting to mitochondrion;visual perception",null,"integral component of membrane;mitochondrial inner membrane;mitochondrion;protein complex",{"$nulls":3},8,8,8,"62.9","62.9","62.9","12.498",0,"88.897",277740000,23,"0.415749",1,"0.803666","0.97691","sp|Q96DA6|TIM14_HUMAN;tr|F2Z3A7|F2Z3A7_HUMAN;tr|G5E9V2|G5E9V2_HUMAN","sp|Q96DA6|TIM14_HUMAN;tr|F2Z3A7|F2Z3A7_HUMAN;tr|G5E9V2|G5E9V2_HUMAN",3838,"Q96DA6","TIM14_HUMAN","Mitochondrial import inner membrane translocase subunit TIM14",null,"DNAJC19"]
["24.5287","22.7158","22.0055","23.1088","21.8126","21.9208",{"$nulls":3},"regulation of cellular respiration","2 iron, 2 sulfur cluster binding;identical protein binding;metal ion binding","extracellular exosome;integral component of membrane;mitochondrial outer membrane;mitochondrion",{"$nulls":3},4,4,4,"44.4","44.4","44.4","12.199",0,"52.556",443960000,29,"0.395042",1,"0.802615","0.935095","sp|Q9NZ45|CISD1_HUMAN","sp|Q9NZ45|CISD1_HUMAN",4867,"Q9NZ45","CISD1_HUMAN","CDGSH iron-sulfur domain-containing protein 1",null,"CISD1"]
["22.6966","21.0117","21.7549","21.8432","19.605","21.6094",{"$nulls":3},"mitochondrial ATP synthesis coupled electron transport;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;response to oxidative stress","4 iron, 4 sulfur cluster binding;electron transfer activity;metal ion binding;NAD binding;NADH dehydrogenase (ubiquinone) activity;quinone binding;ubiquitin protein ligase binding","mitochondrial matrix;mitochondrial respiratory chain complex I;mitochondrion;nucleoplasm","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,13,13,13,"40.2","40.2","40.2","52.545",0,"83.649",761580000,86,"0.392914",1,"0.801875","0.93078","sp|O75306|NDUS2_HUMAN","sp|O75306|NDUS2_HUMAN",564,"O75306","NDUS2_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial",null,"NDUFS2"]
["21.8605","20.3524","21.7887","20.94","19.5097","21.1467",{"$nulls":3},"cellular response to lipopolysaccharide;MAPK cascade;modification by virus of host mRNA processing;mRNA 3'-end processing;mRNA splicing, via spliceosome;muscle contraction;poly(A)+ mRNA export from nucleus;positive regulation of polynucleotide adenylyltransferase activity;RNA processing;termination of RNA polymerase II transcription","RNA binding;RNA polymerase binding","cytoplasm;intracellular ribonucleoprotein complex;nuclear inclusion body;nuclear speck;nucleoplasm;nucleus","Influenza A;mRNA surveillance pathway",null,null,6,6,6,"38.6","38.6","38.6","32.749",0,"46.423",264890000,20,"0.491041",1,"0.801709","1.12688","sp|Q86U42|PABP2_HUMAN;tr|B4DEH8|B4DEH8_HUMAN;tr|G3V4T2|G3V4T2_HUMAN;tr|H0YJH9|H0YJH9_HUMAN","sp|Q86U42|PABP2_HUMAN;tr|B4DEH8|B4DEH8_HUMAN;tr|G3V4T2|G3V4T2_HUMAN",3212,"Q86U42","PABP2_HUMAN","Polyadenylate-binding protein 2","ABP-2;oly(A)-binding protein 2","PABPN1"]
["20.8612","19.0631","20.3591","20.2984","17.6135","19.9699",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;cellular response to cytokine stimulus;negative regulation of cell migration;negative regulation of neuron projection development;neuron development;positive regulation of filopodium assembly;positive regulation of neuron projection development;protein homooligomerization;response to axon injury","chondroitin sulfate binding;filamin binding;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;SH3 domain binding","cell body;cytosol;exocytic vesicle;extracellular space;filamentous actin;growth cone;lamellipodium",{"$nulls":3},14,11,10,"39.1","31.4","30.2","61.963",0,"48.889",313070000,36,"0.329171",1,"0.800544","0.799804","sp|Q14195|DPYL3_HUMAN;tr|H0YBT4|H0YBT4_HUMAN;tr|D6RF19|D6RF19_HUMAN;tr|H0YB87|H0YB87_HUMAN;sp|Q14117|DPYS_HUMAN","sp|Q14195|DPYL3_HUMAN",2453,"Q14195","DPYL3_HUMAN","Dihydropyrimidinase-related protein 3","RP-3","DPYSL3"]
["19.1059","17.6822","19.0218","18.1888","16.9069","18.3127",{"$nulls":3},"negative regulation of chromatin binding;negative regulation of transcription from RNA polymerase II promoter;positive regulation of G1/S transition of mitotic cell cycle;RNA methylation;snRNA metabolic process;snRNA modification","RNA binding;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity",{"$nulls":4},6,6,6,"15.4","15.4","15.4","74.354",0,"71.117",119660000,19,"0.550213",1,"0.8005","1.24315","sp|Q7L2J0|MEPCE_HUMAN","sp|Q7L2J0|MEPCE_HUMAN",3120,"Q7L2J0","MEPCE_HUMAN","7SK snRNA methylphosphate capping enzyme","ePCE","MEPCE"]
["13.9167","13.017","13.756","14.2561","11.6224","12.4108",{"$nulls":9},2,2,2,1,1,1,"333.2","0.0019264","3.0607",9731700,3,"0.410421",1,"0.800138","0.966179","tr|D6RGG3|D6RGG3_HUMAN;sp|Q99715|COCA1_HUMAN;tr|H0Y4P7|H0Y4P7_HUMAN;tr|A0A087X0A8|A0A087X0A8_HUMAN","tr|D6RGG3|D6RGG3_HUMAN;sp|Q99715|COCA1_HUMAN;tr|H0Y4P7|H0Y4P7_HUMAN;tr|A0A087X0A8|A0A087X0A8_HUMAN",4098,"D6RGG3","D6RGG3_HUMAN",null,null,"COL12A1"]
["23.3246","23.7705","23.7701","22.3952","23.3302","22.7418",{"$nulls":3},"protein homotetramerization;visual perception;xenobiotic catabolic process","mRNA 3'-UTR binding;NADPH binding;NADPH:quinone reductase activity;zinc ion binding","cytosol;extracellular exosome",{"$nulls":3},14,14,14,"59.3","59.3","59.3","35.206",0,"116.89",1935900000,66,"1.20891",1,"0.799339","2.5725","sp|Q08257|QOR_HUMAN;tr|A6NP24|A6NP24_HUMAN;tr|C9JH92|C9JH92_HUMAN","sp|Q08257|QOR_HUMAN;tr|A6NP24|A6NP24_HUMAN;tr|C9JH92|C9JH92_HUMAN",2227,"Q08257","QOR_HUMAN","Quinone oxidoreductase",null,"CRYZ"]
["24.9584","22.7661","24.5904","24.4147","21.1451","24.358",{"$nulls":3},"mitochondrial electron transport, ubiquinol to cytochrome c;response to antibiotic;response to drug;response to hormone","2 iron, 2 sulfur cluster binding;metal ion binding;protein complex binding;ubiquinol-cytochrome-c reductase activity","integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrial respiratory chain complex IV;mitochondrion","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,10,10,10,"34.3","34.3","34.3","29.668",0,"165.9",2233100000,93,"0.24793",1,"0.798989","0.626395","sp|P47985|UCRI_HUMAN;sp|P0C7P4|UCRIL_HUMAN","sp|P47985|UCRI_HUMAN;sp|P0C7P4|UCRIL_HUMAN",1618,"P47985","UCRI_HUMAN","Cytochrome b-c1 complex subunit Rieske, mitochondrial",null,"UQCRFS1"]
["23.3298","22.4193","22.41","21.9455","21.5415","22.2754",{"$nulls":4},"RNA binding","cytosol;nucleoplasm",{"$nulls":3},5,5,5,"25.1","25.1","25.1","35.02",0,"45.89",479690000,24,"1.00876",1,"0.798913","2.14981","tr|K7EQ02|K7EQ02_HUMAN;tr|K7EQ55|K7EQ55_HUMAN;tr|K7EK33|K7EK33_HUMAN;sp|Q96EP5|DAZP1_HUMAN","tr|K7EQ02|K7EQ02_HUMAN;tr|K7EQ55|K7EQ55_HUMAN;tr|K7EK33|K7EK33_HUMAN;sp|Q96EP5|DAZP1_HUMAN",3860,"K7EQ02","K7EQ02_HUMAN",null,null,"DAZAP1"]
["22.2828","19.802","21.0787","20.7716","18.954","21.0435",{"$nulls":3},"cell redox homeostasis;IRE1-mediated unfolded protein response;oxidation-reduction process;protein folding;response to endoplasmic reticulum stress","oxidoreductase activity;peptide disulfide oxidoreductase activity;protein disulfide isomerase activity","endoplasmic reticulum lumen;endoplasmic reticulum membrane",{"$nulls":3},19,19,19,"45.7","45.7","45.7","59.594",0,"112.19",1475000000,136,"0.339745",1,"0.798134","0.82179","sp|Q14554|PDIA5_HUMAN;tr|C9JY10|C9JY10_HUMAN;tr|H7C4F9|H7C4F9_HUMAN","sp|Q14554|PDIA5_HUMAN",2480,"Q14554","PDIA5_HUMAN","Protein disulfide-isomerase A5",null,"PDIA5"]
["17.3957","18.1823","18.9651","18.1014","15.3867","18.6659",{"$nulls":3},"enzyme-directed rRNA 2'-O-methylation;rRNA 2'-O-methylation","RNA binding;rRNA (guanosine-2'-O-)-methyltransferase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},2,2,2,"6.5","6.5","6.5","38.638","0.0011924","3.4767",37470000,3,"0.290414",1,"0.7964","0.718155","sp|Q6IN84|MRM1_HUMAN;tr|A0A087WZC1|A0A087WZC1_HUMAN","sp|Q6IN84|MRM1_HUMAN;tr|A0A087WZC1|A0A087WZC1_HUMAN",2963,"Q6IN84","MRM1_HUMAN","rRNA methyltransferase 1, mitochondrial {ECO:0000303|PubMed:24036117}",null,"MRM1"]
["19.3608","18.3103","18.8739","18.876","16.9619","18.3185",{"$nulls":3},"O-glycan processing;protein O-linked glycosylation;protein O-linked glycosylation via serine;protein O-linked glycosylation via threonine","carbohydrate binding;manganese ion binding;polypeptide N-acetylgalactosaminyltransferase activity","endoplasmic reticulum membrane;extracellular region;Golgi cisterna membrane;Golgi membrane;integral component of membrane;membrane;perinuclear region of cytoplasm","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,4,4,4,"9.7","9.7","9.7","64.218",0,"7.1327",105050000,11,"0.546358",1,"0.79616","1.23561","sp|Q10472|GALT1_HUMAN;tr|K7EJV8|K7EJV8_HUMAN","sp|Q10472|GALT1_HUMAN;tr|K7EJV8|K7EJV8_HUMAN",2251,"Q10472","GALT1_HUMAN","Polypeptide N-acetylgalactosaminyltransferase 1",null,"GALNT1"]
["26.0354","23.1742","25.3342","25.2792","21.8701","25.0144",{"$nulls":3},"mitochondrial transport;transport","phosphate:proton symporter activity;protein complex binding","extracellular exosome;integral component of plasma membrane;membrane;mitochondrial inner membrane;mitochondrion;myelin sheath",{"$nulls":3},11,11,11,32,32,32,"40.094",0,"117.86",14055000000,320,"0.222257",1,"0.793338","0.569563","sp|Q00325|MPCP_HUMAN;tr|F8VVM2|F8VVM2_HUMAN;tr|F8VZL5|F8VZL5_HUMAN;tr|F8VWR4|F8VWR4_HUMAN;tr|F8VWQ0|F8VWQ0_HUMAN","sp|Q00325|MPCP_HUMAN;tr|F8VVM2|F8VVM2_HUMAN",2115,"Q00325","MPCP_HUMAN","Phosphate carrier protein, mitochondrial",null,"SLC25A3"]
["26.9768","25.4224","26.1927","26.0126","24.2726","25.9332",{"$nulls":3},"anion transport;binding of sperm to zona pellucida;negative regulation of intrinsic apoptotic signaling pathway;negative regulation of protein polymerization","nucleotide binding;porin activity;voltage-gated anion channel activity","acrosomal vesicle;extracellular exosome;membrane raft;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrial outer membrane;mitochondrion;myelin sheath;nucleus;pore complex;synaptic vesicle","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholesterol metabolism;Ferroptosis;Human T-cell leukemia virus 1 infection;Huntington disease;Necroptosis;NOD-like receptor signaling pathway;Parkinson disease",null,null,15,15,15,"64.6","64.6","64.6","31.566",0,"323.31",10545000000,275,"0.474374",1,"0.791202","1.09391","sp|P45880|VDAC2_HUMAN;tr|A0A0A0MR02|A0A0A0MR02_HUMAN;tr|Q5JSD2|Q5JSD2_HUMAN;tr|Q5JSD1|Q5JSD1_HUMAN;tr|A2A3S1|A2A3S1_HUMAN","sp|P45880|VDAC2_HUMAN;tr|A0A0A0MR02|A0A0A0MR02_HUMAN;tr|Q5JSD2|Q5JSD2_HUMAN;tr|Q5JSD1|Q5JSD1_HUMAN",1578,"P45880","VDAC2_HUMAN","Voltage-dependent anion-selective channel protein 2","DAC-2;VDAC2","VDAC2"]
["24.423","22.762","23.5667","23.1582","22.2038","23.0239",{"$nulls":3},"mesoderm development;phagocytosis;positive regulation of skeletal muscle acetylcholine-gated channel clustering;protein folding;protein localization to cell surface;Wnt signaling pathway","identical protein binding;low-density lipoprotein particle receptor binding","endoplasmic reticulum;plasma membrane",{"$nulls":3},12,12,12,"48.3","48.3","48.3","26.076",0,"132.42",909050000,48,"0.628733",1,"0.788624","1.39637","sp|Q14696|MESD_HUMAN;tr|H0YLI4|H0YLI4_HUMAN","sp|Q14696|MESD_HUMAN",2500,"Q14696","MESD_HUMAN","LRP chaperone MESD {ECO:0000305}",null,"MESD"]
["23.4008","21.9805","21.944","21.9189","21.1016","21.9427",{"$nulls":3},"dephosphorylation of RNA polymerase II C-terminal domain;positive regulation of cell proliferation;positive regulation of transcription from RNA polymerase II promoter;regulation of cell cycle process;snRNA transcription from RNA polymerase II promoter","identical protein binding;RNA polymerase II core binding","centrosome;cytosol;DNA-directed RNA polymerase II, holoenzyme;nucleoplasm;nucleus",{"$nulls":3},10,10,8,"48.2","48.2","36.8","36.899",0,"78.727",576230000,41,"0.642038",1,"0.787384","1.42228","sp|Q9NQG5|RPR1B_HUMAN;tr|E9PIQ9|E9PIQ9_HUMAN;tr|A2A2M0|A2A2M0_HUMAN;tr|E9PQF3|E9PQF3_HUMAN;tr|A0A087WUK3|A0A087WUK3_HUMAN;tr|A0A087X2D2|A0A087X2D2_HUMAN;tr|K7EQR8|K7EQR8_HUMAN","sp|Q9NQG5|RPR1B_HUMAN",4655,"Q9NQG5","RPR1B_HUMAN","Regulation of nuclear pre-mRNA domain-containing protein 1B",null,"RPRD1B"]
["21.6854","21.3549","20.4129","19.8911","21.0898","20.119",{"$nulls":3},"antigen processing and presentation of peptide antigen via MHC class I;immune response",null,"integral component of membrane;MHC class I protein complex",{"$nulls":3},14,10,0,"45.1","31.7",0,"40.71",0,"36.216",403330000,33,"0.672342",1,"0.784416","1.4813","tr|O19617|O19617_HUMAN","tr|O19617|O19617_HUMAN",5603,"O19617","O19617_HUMAN"]
["23.0408","20.7863","22.52","22.9277","18.9597","22.1088",{"$nulls":3},"fatty acid beta-oxidation;negative regulation of insulin secretion;response to activity;response to drug;response to insulin","3-hydroxyacyl-CoA dehydrogenase activity;NAD+ binding","cytoplasm;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;nucleoplasm","Butanoate metabolism;Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Lysine degradation;Metabolic pathways;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,11,11,11,"53.8","53.8","53.8","34.293",0,"118.87",584680000,51,"0.219974",1,"0.783621","0.564452","sp|Q16836|HCDH_HUMAN;tr|E9PF18|E9PF18_HUMAN;tr|A0A0A0MSE2|A0A0A0MSE2_HUMAN","sp|Q16836|HCDH_HUMAN;tr|E9PF18|E9PF18_HUMAN;tr|A0A0A0MSE2|A0A0A0MSE2_HUMAN",2699,"Q16836","HCDH_HUMAN","Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial","CDH","HADH"]
["22.601","21.5905","21.6731","21.3374","20.6919","21.4858",{"$nulls":3},"calcium ion transmembrane transport;endoplasmic reticulum calcium ion homeostasis;ER overload response","calcium channel activity","endoplasmic reticulum;Golgi membrane;integral component of endoplasmic reticulum membrane",{"$nulls":3},4,4,4,"24.5","24.5","24.5","21.175",0,"95.258",822800000,75,"0.901234",1,"0.783147","1.93194","sp|Q9UM00|TMCO1_HUMAN;tr|J9JIE6|J9JIE6_HUMAN;tr|J3QQY2|J3QQY2_HUMAN;tr|J3KS45|J3KS45_HUMAN;tr|J3KTQ7|J3KTQ7_HUMAN","sp|Q9UM00|TMCO1_HUMAN;tr|J9JIE6|J9JIE6_HUMAN;tr|J3QQY2|J3QQY2_HUMAN;tr|J3KS45|J3KS45_HUMAN",5139,"Q9UM00","TMCO1_HUMAN","Calcium load-activated calcium channel {ECO:0000305|PubMed:27212239}","LAC channel {ECO:0000305|PubMed:27212239}","TMCO1"]
["23.6135","23.1446","23.277","23.0798","21.8798","22.7291",{"$nulls":3},"mRNA splicing, via spliceosome;regulation of mRNA polyadenylation","identical protein binding;RNA binding;snRNA stem-loop binding;U1 snRNA binding;U1 snRNP binding","nucleoplasm;spliceosomal complex;U1 snRNP","Spliceosome",null,null,8,8,6,"37.6","37.6","32.3","31.279",0,"46.499",1367500000,56,"0.957011",1,"0.782129","2.04428","sp|P09012|SNRPA_HUMAN;tr|M0R268|M0R268_HUMAN;tr|M0R0G9|M0R0G9_HUMAN;tr|M0QXK2|M0QXK2_HUMAN;tr|M0R221|M0R221_HUMAN;tr|M0R2B8|M0R2B8_HUMAN;tr|M0QZG7|M0QZG7_HUMAN","sp|P09012|SNRPA_HUMAN;tr|M0R268|M0R268_HUMAN;tr|M0R0G9|M0R0G9_HUMAN;tr|M0QXK2|M0QXK2_HUMAN;tr|M0R221|M0R221_HUMAN;tr|M0R2B8|M0R2B8_HUMAN;tr|M0QZG7|M0QZG7_HUMAN",979,"P09012","SNRPA_HUMAN","U1 small nuclear ribonucleoprotein A","1 snRNP A;1A;1-A","SNRPA"]
["22.2218","22.9487","23.1139","20.7963","22.4493","22.6945",{"$nulls":3},"RNA phosphodiester bond hydrolysis, exonucleolytic;rRNA catabolic process","3'-5' exonuclease activity;5'-3' exonuclease activity;RNA binding",{"$nulls":4},4,4,4,"26.7","26.7","26.7","18.419",0,"21.322",350780000,26,"0.523672",1,"0.781429","1.19112","sp|Q9BQ61|CS043_HUMAN;tr|K7ELS0|K7ELS0_HUMAN;tr|K7ERU7|K7ERU7_HUMAN;tr|K7EN60|K7EN60_HUMAN","sp|Q9BQ61|CS043_HUMAN;tr|K7ELS0|K7ELS0_HUMAN;tr|K7ERU7|K7ERU7_HUMAN;tr|K7EN60|K7EN60_HUMAN",4137,"Q9BQ61","TRIR_HUMAN","Telomerase RNA component interacting RNase {ECO:0000303|PubMed:28322335, ECO:0000312|HGNC:HGNC:28424}",null,"TRIR"]
["19.0312","15.6562","18.3217","17.6153","14.5085","18.5533",{"$nulls":3},"protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan","mannosyltransferase activity","integral component of membrane;membrane;nuclear inner membrane",{"$nulls":3},5,5,5,"10.8","10.8","10.8","77.318",0,"10.511",100520000,20,"0.185847",1,"0.777315","0.486819","sp|Q2PZI1|D19L1_HUMAN;tr|F5H1L7|F5H1L7_HUMAN;tr|H7C3M5|H7C3M5_HUMAN;tr|H7C1I8|H7C1I8_HUMAN;sp|Q6NUT2|D19L2_HUMAN","sp|Q2PZI1|D19L1_HUMAN",2719,"Q2PZI1","D19L1_HUMAN","Probable C-mannosyltransferase DPY19L1",null,"DPY19L1"]
["18.9917","14.6096","18.0369","16.2275","14.4345","18.646",{"$nulls":3},"RNA secondary structure unwinding;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;membrane;nucleolus;nucleoplasm",{"$nulls":3},12,12,12,"31.1","31.1","31.1","67.497",0,"270.48",460590000,46,"0.161676",1,"0.776747","0.430273","sp|Q9Y2R4|DDX52_HUMAN;tr|A0A087X1P7|A0A087X1P7_HUMAN;tr|A0A087WTD6|A0A087WTD6_HUMAN;tr|A0A087X069|A0A087X069_HUMAN;tr|A0A087X121|A0A087X121_HUMAN","sp|Q9Y2R4|DDX52_HUMAN",5234,"Q9Y2R4","DDX52_HUMAN","Probable ATP-dependent RNA helicase DDX52",null,"DDX52"]
["23.948","24.0738","24.0552","23.0961","22.6585","23.9928",{"$nulls":3},"nucleosome assembly","cadherin binding;DNA binding;RNA binding","nucleolus;nucleosome;nucleus",{"$nulls":3},10,10,10,"39.9","39.9","39.9","22.487",0,"133.53",9606600000,213,"0.918997",1,"0.776519","1.96757","sp|Q92522|H1X_HUMAN","sp|Q92522|H1X_HUMAN",3668,"Q92522","H1X_HUMAN","Histone H1x",null,"H1FX"]
["19.2706","15.7413","17.2057","17.0542","15.2609","17.5762",{"$nulls":3},"defense response to virus;interferon-gamma-mediated signaling pathway;negative regulation of viral genome replication;nucleobase-containing compound metabolic process;regulation of ribonuclease activity;response to virus;type I interferon signaling pathway","2'-5'-oligoadenylate synthetase activity;ATP binding;double-stranded RNA binding;metal ion binding","cytoplasm;cytosol;extracellular space;intracellular membrane-bounded organelle;nucleoplasm;plasma membrane","Epstein-Barr virus infection;Hepatitis C;Herpes simplex virus 1 infection;Influenza A;Measles;NOD-like receptor signaling pathway",null,null,12,12,12,"16.9","16.9","16.9","121.17",0,"48.145",143090000,19,"0.247263",1,"0.775433","0.624932","sp|Q9Y6K5|OAS3_HUMAN;tr|F8VS35|F8VS35_HUMAN;tr|F8VWK9|F8VWK9_HUMAN","sp|Q9Y6K5|OAS3_HUMAN",5413,"Q9Y6K5","OAS3_HUMAN","2'-5'-oligoadenylate synthase 3","2-5')oligo(A) synthase 3;-5A synthase 3","OAS3"]
["19.017","16.1395","18.5018","17.4759","15.8377","18.0186",{"$nulls":3},"phospholipid biosynthetic process","phosphatidylserine decarboxylase activity","integral component of membrane;mitochondrial inner membrane;nucleus","Glycerophospholipid metabolism;Metabolic pathways",null,null,8,8,8,"21.8","21.8","21.8","46.671",0,"20.025",120850000,13,"0.283583",1,"0.775355","0.703574","sp|Q9UG56|PISD_HUMAN;tr|H0Y7P7|H0Y7P7_HUMAN;tr|B1AKM8|B1AKM8_HUMAN;tr|B1AKM6|B1AKM6_HUMAN","sp|Q9UG56|PISD_HUMAN;tr|H0Y7P7|H0Y7P7_HUMAN;tr|B1AKM8|B1AKM8_HUMAN;tr|B1AKM6|B1AKM6_HUMAN",4998,"Q9UG56","PISD_HUMAN","Phosphatidylserine decarboxylase proenzyme, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03208}",null,"PISD"]
["24.0416","22.4879","22.4216","22.6809","21.7449","22.2009",{"$nulls":3},"aerobic respiration;respiratory electron transport chain;succinate metabolic process;tricarboxylic acid cycle","2 iron, 2 sulfur cluster binding;3 iron, 4 sulfur cluster binding;4 iron, 4 sulfur cluster binding;electron transfer activity;metal ion binding;succinate dehydrogenase (ubiquinone) activity;ubiquinone binding","extracellular exosome;mitochondrial inner membrane;mitochondrial membrane;mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);mitochondrion;nucleoplasm;plasma membrane","Alzheimer disease;Carbon metabolism;Citrate cycle (TCA cycle);Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,12,12,12,"38.6","38.6","38.6","31.629",0,"70.255",1336500000,60,"0.581223",1,"0.774796","1.30376","sp|P21912|SDHB_HUMAN;tr|A0A087WWT1|A0A087WWT1_HUMAN;tr|A0A087WXX8|A0A087WXX8_HUMAN","sp|P21912|SDHB_HUMAN;tr|A0A087WWT1|A0A087WWT1_HUMAN;tr|A0A087WXX8|A0A087WXX8_HUMAN",1233,"P21912","SDHB_HUMAN","Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial",null,"SDHB"]
["16.9341","15.5615","16.3823","14.6143","15.228","16.7124",{"$nulls":3},"regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;transcription initiation from RNA polymerase II promoter","transcription coactivator activity","nucleoplasm;transcription factor complex",{"$nulls":3},13,13,13,"10.5","10.5","10.5","156.47",0,"35.388",222370000,39,"0.450842",1,"0.774402","1.04717","sp|Q9ULK4|MED23_HUMAN;tr|Q5JWT2|Q5JWT2_HUMAN","sp|Q9ULK4|MED23_HUMAN;tr|Q5JWT2|Q5JWT2_HUMAN",5126,"Q9ULK4","MED23_HUMAN","Mediator of RNA polymerase II transcription subunit 23",null,"MED23"]
["16.8952","16.5243","16.2384","15.224","15.6686","16.4424",{"$nulls":3},"cellular response to hydroxyurea;chromatin remodeling;chromosome organization involved in meiotic cell cycle;covalent chromatin modification;DNA damage response, signal transduction by p53 class mediator;DNA methylation;DNA recombination;DNA repair;DNA replication-independent nucleosome assembly;forebrain development;meiotic spindle organization;multicellular organism growth;negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric;negative regulation of telomeric RNA transcription from RNA pol II promoter;nucleosome assembly;positive regulation of nuclear cell cycle DNA replication;positive regulation of telomere maintenance;positive regulation of telomeric RNA transcription from RNA pol II promoter;positive regulation of transcription from RNA polymerase II promoter;post-embryonic forelimb morphogenesis;protein localization to chromosome, telomeric region;regulation of histone H3-K9 trimethylation;regulation of transcription, DNA-templated;replication fork processing;seminiferous tubule development;Sertoli cell development;spermatogenesis;transcription, DNA-templated","ATP binding;chromatin binding;chromo shadow domain binding;DNA binding;DNA helicase activity;DNA translocase activity;helicase activity;histone binding;metal ion binding;methylated histone binding","condensed nuclear chromosome, centromeric region;nuclear body;nuclear chromosome, telomeric region;nuclear heterochromatin;nuclear pericentric heterochromatin;nuclear subtelomeric heterochromatin;nucleoplasm;nucleus;pericentric heterochromatin;PML body;SWI/SNF superfamily-type complex;telomeric heterochromatin",{"$nulls":3},17,17,17,"8.9","8.9","8.9","282.58",0,"51.873",346640000,52,"0.894615",1,"0.774332","1.91869","sp|P46100|ATRX_HUMAN;tr|A0A096LNW1|A0A096LNW1_HUMAN;tr|A0A096LNL9|A0A096LNL9_HUMAN;tr|A0A087WWG0|A0A087WWG0_HUMAN;tr|A0A096LNN3|A0A096LNN3_HUMAN;tr|A0A096LPG6|A0A096LPG6_HUMAN;tr|A0A096LNX6|A0A096LNX6_HUMAN;tr|A0A096LNL6|A0A096LNL6_HUMAN;tr|A0A096LP59|A0A096LP59_HUMAN","sp|P46100|ATRX_HUMAN",1587,"P46100","ATRX_HUMAN","Transcriptional regulator ATRX",null,"ATRX"]
["22.8458","20.2593","21.2418","21.3289","19.8391","20.858",{"$nulls":4},"oxidoreductase activity","membrane;mitochondrion;peroxisome",{"$nulls":3},16,16,16,55,55,55,"45.394",0,"81.768",776750000,60,"0.37118",1,"0.773622","0.88652","sp|Q6YN16|HSDL2_HUMAN","sp|Q6YN16|HSDL2_HUMAN",3075,"Q6YN16","HSDL2_HUMAN","Hydroxysteroid dehydrogenase-like protein 2",null,"HSDL2"]
["19.499","18.083","18.179","18.2427","18.278","16.9197",{"$nulls":3},"Golgi organization;Golgi vesicle transport;retrograde transport, vesicle recycling within Golgi","protein homodimerization activity;Rab GTPase binding","cis-Golgi network;Golgi apparatus;Golgi cisterna;Golgi membrane;integral component of membrane;membrane;transport vesicle",{"$nulls":3},9,9,9,"21.6","21.6","21.6","83.023",0,"35.84",159040000,28,"0.5334",1,"0.77349","1.21022","sp|Q8TBA6|GOGA5_HUMAN;tr|H0YK03|H0YK03_HUMAN","sp|Q8TBA6|GOGA5_HUMAN",3541,"Q8TBA6","GOGA5_HUMAN","Golgin subfamily A member 5",null,"GOLGA5"]
["26.9028","26.3679","26.378","26.3287","25.1464","25.8549",{"$nulls":5},"extracellular exosome;integral component of membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrion",{"$nulls":3},3,3,3,"44.8","44.8","44.8","6.4575",0,"148.8",2540400000,67,"0.935569",1,"0.772929","2.00093","sp|Q96IX5|USMG5_HUMAN","sp|Q96IX5|USMG5_HUMAN",3931,"Q96IX5","USMG5_HUMAN","Up-regulated during skeletal muscle growth protein 5",null,"USMG5"]
["23.7986","22.4903","23.0695","23.0015","21.4941","22.5455",{"$nulls":3},"actin cytoskeleton organization;cellular response to interferon-gamma;cytoskeletal anchoring at plasma membrane;epithelial cell morphogenesis;keratinocyte development;signal transduction;skeletal muscle tissue development","actin binding;cadherin binding;identical protein binding;RNA binding","actin cytoskeleton;brush border;cell cortex;cytoplasm;cytosol;extracellular exosome;extracellular matrix;focal adhesion;integral component of membrane;phagocytic vesicle;plasma membrane;stress fiber;Z disc","Focal adhesion;MAPK signaling pathway;Proteoglycans in cancer;Salmonella infection",null,null,128,120,116,"69.8","67.4","65.3","278.16",0,"323.31",11576000000,637,"0.589572",1,"0.772476","1.32005","sp|O75369|FLNB_HUMAN;tr|E7EN95|E7EN95_HUMAN;tr|A0A0A0MT44|A0A0A0MT44_HUMAN;tr|H7C5L4|H7C5L4_HUMAN;tr|A0A0C4DGA1|A0A0C4DGA1_HUMAN","sp|O75369|FLNB_HUMAN;tr|E7EN95|E7EN95_HUMAN",575,"O75369","FLNB_HUMAN","Filamin-B","LN-B","FLNB"]
["21.1253","18.5422","20.7292","19.9438","17.9361","20.2007",{"$nulls":3},"inner mitochondrial membrane organization;mitochondrial calcium ion homeostasis;mitochondrial calcium ion transmembrane transport;mitochondrial calcium uptake;mitochondrial respiratory chain complex III biogenesis;mitochondrial respiratory chain complex IV biogenesis;protein insertion into mitochondrial membrane;protein insertion into mitochondrial membrane from inner side","ribosome binding","mitochondrial inner membrane;mitochondrial matrix",{"$nulls":3},4,4,4,"16.2","16.2","16.2","32.544",0,"15.131",300830000,22,"0.290119",1,"0.772031","0.717527","sp|Q8WWC4|CB047_HUMAN;tr|H7C0V0|H7C0V0_HUMAN","sp|Q8WWC4|CB047_HUMAN;tr|H7C0V0|H7C0V0_HUMAN",3633,"Q8WWC4","MAIP1_HUMAN","m-AAA protease-interacting protein 1, mitochondrial {ECO:0000303|PubMed:27642048}",null,"MAIP1"]
["15.7563","15.1496","17.7414","15.6332","14.1636","16.5352",{"$nulls":4},"actin binding;cadherin binding","actin cytoskeleton;cytosol;focal adhesion",{"$nulls":3},12,11,11,"15.8","14.9","14.9","116.53",0,"38.32",179610000,23,"0.30028",1,"0.771736","0.739109","sp|Q6WCQ1|MPRIP_HUMAN;tr|J3KSW8|J3KSW8_HUMAN;tr|H0Y2S9|H0Y2S9_HUMAN;tr|H0Y7E2|H0Y7E2_HUMAN;tr|H7C3G6|H7C3G6_HUMAN;tr|K7EL39|K7EL39_HUMAN;tr|J3KSK7|J3KSK7_HUMAN;tr|J3QRL2|J3QRL2_HUMAN","sp|Q6WCQ1|MPRIP_HUMAN;tr|J3KSW8|J3KSW8_HUMAN;tr|H0Y2S9|H0Y2S9_HUMAN",3068,"Q6WCQ1","MPRIP_HUMAN","Myosin phosphatase Rho-interacting protein",{"$f":"-RIP","v":{"$error":"#NAME?"}},"MPRIP"]
["25.6862","25.1645","24.781","24.9072","23.8823","24.5278",{"$nulls":3},"ATP biosynthetic process;cristae formation;mitochondrial ATP synthesis coupled proton transport","hydrogen ion transmembrane transporter activity;transmembrane transporter activity","mitochondrial inner membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);mitochondrion","Metabolic pathways;Oxidative phosphorylation;Thermogenesis",null,null,4,4,4,"52.2","52.2","52.2","7.9331",0,"13.052",752410000,32,"0.904723",1,"0.771459","1.93893","sp|P56385|ATP5I_HUMAN","sp|P56385|ATP5I_HUMAN",1866,"P56385","ATP5I_HUMAN","ATP synthase subunit e, mitochondrial","TPase subunit e","ATP5I"]
["24.1476","23.7299","23.5975","23.5301","22.4706","23.1623",{"$nulls":3},"cellular nitrogen compound metabolic process;generation of precursor metabolites and energy;L-lysine catabolic process to acetyl-CoA via saccharopine;lysine catabolic process;tricarboxylic acid cycle","dihydrolipoyllysine-residue succinyltransferase activity","extracellular exosome;membrane;mitochondrial matrix;myelin sheath;nucleus;oxoglutarate dehydrogenase complex","Carbon metabolism;Citrate cycle (TCA cycle);Lysine degradation;Metabolic pathways;Tryptophan metabolism",null,null,17,17,17,"42.6","42.6","42.6","48.755",0,"206.37",2535300000,103,"1.02793",1,"0.770713","2.18925","sp|P36957|ODO2_HUMAN;tr|Q86SW4|Q86SW4_HUMAN;tr|H0YJF9|H0YJF9_HUMAN;tr|G3V3F0|G3V3F0_HUMAN;tr|G3V5M3|G3V5M3_HUMAN","sp|P36957|ODO2_HUMAN;tr|Q86SW4|Q86SW4_HUMAN",1492,"P36957","ODO2_HUMAN","Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial",null,"DLST"]
["21.6982","19.7107","19.9041","19.8459","19.4444","19.7118",{"$nulls":3},"cellular response to stimulus;central nervous system development;myelination;oligodendrocyte development;ovarian follicle development;regulation of molecular function;regulation of translational initiation;response to glucose;response to heat;response to peptide hormone;translational initiation","ATP binding;GTP binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex","Herpes simplex virus 1 infection;RNA transport",null,null,9,9,9,"31.1","31.1","31.1","38.989",0,"64.533",517350000,44,"0.526572",1,"0.770331","1.19682","sp|P49770|EI2BB_HUMAN;tr|H0YJJ8|H0YJJ8_HUMAN;tr|G3V5E5|G3V5E5_HUMAN;tr|H0YK01|H0YK01_HUMAN","sp|P49770|EI2BB_HUMAN;tr|H0YJJ8|H0YJJ8_HUMAN;tr|G3V5E5|G3V5E5_HUMAN",1681,"P49770","EI2BB_HUMAN","Translation initiation factor eIF-2B subunit beta",null,"EIF2B2"]
["17.9999","16.7185","15.8079","16.5092","16.1628","15.5476",{"$nulls":5},"nuclear body;nucleoplasm",{"$nulls":3},12,12,12,"9.5","9.5","9.5","209.02",0,"34.909",142110000,23,"0.480517",1,"0.768924","1.10608","tr|A6NNK5|A6NNK5_HUMAN;sp|Q12888|TP53B_HUMAN;tr|C9JXV0|C9JXV0_HUMAN;tr|M0R142|M0R142_HUMAN;tr|H7C3N7|H7C3N7_HUMAN;tr|H7BZY0|H7BZY0_HUMAN","tr|A6NNK5|A6NNK5_HUMAN;sp|Q12888|TP53B_HUMAN",2274,"A6NNK5","A6NNK5_HUMAN",null,null,"TP53BP1"]
["25.1319","23.7894","24.3968","23.9944","23.2967","23.7228",{"$nulls":3},"inositol biosynthetic process;inositol phosphate metabolic process;phospholipid biosynthetic process","inositol-3-phosphate synthase activity","cytoplasm;cytosol","Inositol phosphate metabolism;Metabolic pathways",null,null,20,20,20,"48.2","48.2","48.2","61.067",0,"224.76",3590700000,156,"0.811336",1,"0.768059","1.75338","sp|Q9NPH2|INO1_HUMAN;tr|J3QS51|J3QS51_HUMAN;tr|J3KRH4|J3KRH4_HUMAN;tr|J3QKW9|J3QKW9_HUMAN;tr|J3QRY0|J3QRY0_HUMAN;tr|J3QRH1|J3QRH1_HUMAN;tr|J3QLD7|J3QLD7_HUMAN","sp|Q9NPH2|INO1_HUMAN",4640,"Q9NPH2","INO1_HUMAN","Inositol-3-phosphate synthase 1","PS 1","ISYNA1"]
["18.7116","16.9062","17.4733","17.3553","15.654","17.7789",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;metaphase/anaphase transition of mitotic cell cycle;mitotic cell cycle;mitotic metaphase plate congression;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K11-linked ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of exit from mitosis;regulation of mitotic metaphase/anaphase transition;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;ubiquitin-dependent protein catabolic process","ubiquitin-protein transferase activity","anaphase-promoting complex;cytosol;intracellular;nucleoplasm","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis",null,null,8,8,8,"16.1","16.1","16.1","68.833",0,"23.206",61585000,16,"0.384542",1,"0.767661","0.913775","sp|Q9UJX2|CDC23_HUMAN;tr|D6RBY8|D6RBY8_HUMAN;tr|D6RCF8|D6RCF8_HUMAN;tr|H0Y936|H0Y936_HUMAN","sp|Q9UJX2|CDC23_HUMAN",5067,"Q9UJX2","CDC23_HUMAN","Cell division cycle protein 23 homolog",null,"CDC23"]
["22.7348","20.3379","19.7872","22.3906","19.2839","18.889",{"$nulls":5},"integral component of membrane;mitochondrial proton-transporting ATP synthase complex",{"$nulls":3},2,2,2,"24.1","24.1","24.1","6.662","0.0041199","2.6213",156730000,20,"0.207035",1,"0.765452","0.535298","sp|P56378|68MP_HUMAN;tr|A0A0A0MTQ5|A0A0A0MTQ5_HUMAN;tr|G3V556|G3V556_HUMAN","sp|P56378|68MP_HUMAN;tr|A0A0A0MTQ5|A0A0A0MTQ5_HUMAN;tr|G3V556|G3V556_HUMAN",1864,"P56378","68MP_HUMAN","6.8 kDa mitochondrial proteolipid",null,"MP68"]
["21.8208","20.448","20.6447","20.6265","19.8037","20.1873",{"$nulls":3},"DNA damage response, detection of DNA damage;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleolus","Ribosome",null,null,13,13,13,"37.9","37.9","37.9","45.834",0,"59.593",664020000,53,"0.713557",1,"0.765357","1.56167","sp|P82933|RT09_HUMAN;tr|H7BZC4|H7BZC4_HUMAN","sp|P82933|RT09_HUMAN",2085,"P82933","RT09_HUMAN","28S ribosomal protein S9, mitochondrial","9mt;RP-S9","MRPS9"]
["22.3084","20.9922","21.6824","21.3316","20.2435","21.1129",{"$nulls":4},"oxidoreductase activity","membrane",{"$nulls":3},8,8,8,"34.8","34.8","34.8","38.298",0,"87.906",459860000,26,"0.689802",1,"0.76501","1.51533","sp|Q9Y394|DHRS7_HUMAN;tr|A0A087X0Z7|A0A087X0Z7_HUMAN;tr|H0YJ66|H0YJ66_HUMAN;tr|H0YJR8|H0YJR8_HUMAN;tr|H0YJE4|H0YJE4_HUMAN","sp|Q9Y394|DHRS7_HUMAN;tr|A0A087X0Z7|A0A087X0Z7_HUMAN;tr|H0YJ66|H0YJ66_HUMAN;tr|H0YJR8|H0YJR8_HUMAN",5275,"Q9Y394","DHRS7_HUMAN","Dehydrogenase/reductase SDR family member 7",null,"DHRS7"]
["19.8474","18.133","19.1264","18.6949","17.861","18.2561",{"$nulls":3},"apoptotic process;cellular response to dsRNA;cellular response to interleukin-1;cellular response to interleukin-6;cellular response to lipopolysaccharide;cellular response to mechanical stimulus;cellular response to nicotine;cellular response to peptide hormone stimulus;cellular response to tumor necrosis factor;Fc-epsilon receptor signaling pathway;I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;membrane protein intracellular domain proteolysis;negative regulation of apoptotic process;negative regulation of calcidiol 1-monooxygenase activity;negative regulation of cellular protein metabolic process;negative regulation of cholesterol transport;negative regulation of gene expression;negative regulation of inflammatory response;negative regulation of interleukin-12 biosynthetic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of vitamin D biosynthetic process;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of hyaluronan biosynthetic process;positive regulation of lipid storage;positive regulation of macrophage derived foam cell differentiation;positive regulation of miRNA metabolic process;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;response to muscle stretch;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;transcription from RNA polymerase II promoter","actinin binding;chromatin binding;DNA binding transcription factor activity;identical protein binding;protein heterodimerization activity;protein homodimerization activity;RNA polymerase II distal enhancer sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor binding;transcription regulatory region DNA binding;transcription regulatory region sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytoplasm;cytosol;extracellular region;I-kappaB/NF-kappaB complex;mitochondrion;nucleoplasm;nucleus;secretory granule lumen;specific granule lumen","Acute myeloid leukemia;Adipocytokine signaling pathway;AGE-RAGE signaling pathway in diabetic complications;Amoebiasis;Antifolate resistance;Apoptosis;B cell receptor signaling pathway;cAMP signaling pathway;Cellular senescence;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Chronic myeloid leukemia;Cocaine addiction;C-type lectin receptor signaling pathway;Cytosolic DNA-sensing pathway;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fluid shear stress and atherosclerosis;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;IL-17 signaling pathway;Inflammatory bowel disease (IBD);Influenza A;Insulin resistance;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Longevity regulating pathway;MAPK signaling pathway;Measles;MicroRNAs in cancer;Neurotrophin signaling pathway;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Pertussis;PI3K-Akt signaling pathway;Prolactin signaling pathway;Prostate cancer;Ras signaling pathway;Relaxin signaling pathway;RIG-I-like receptor signaling pathway;Salmonella infection;Shigellosis;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Viral carcinogenesis;Yersinia infection",null,null,12,12,12,"16.4","16.4","16.4","105.35",0,"50.164",211220000,20,"0.622875",1,"0.764878","1.38496","sp|P19838|NFKB1_HUMAN;tr|D6RF93|D6RF93_HUMAN;tr|D6RH30|D6RH30_HUMAN;tr|D6RC45|D6RC45_HUMAN","sp|P19838|NFKB1_HUMAN;tr|D6RF93|D6RF93_HUMAN",1200,"P19838","NFKB1_HUMAN","Nuclear factor NF-kappa-B p105 subunit",null,"NFKB1"]
["24.0377","22.3264",1,"21.4393","22.6305",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"14.5","14.5","14.5","9.369","0.0010073","3.6558",103820000,4,"0.0250851",1,"0.764753","0.0749195","tr|A0A087WUD3|A0A087WUD3_HUMAN;sp|Q9NRP0|OSTC_HUMAN","tr|A0A087WUD3|A0A087WUD3_HUMAN;sp|Q9NRP0|OSTC_HUMAN",4696,"A0A087WUD3","A0A087WUD3_HUMAN",null,null,"OSTC"]
["20.7379","19.2448","19.4716","19.5599","17.8988","19.7015",{"$nulls":3},"biotin metabolic process;fatty acid catabolic process;short-chain fatty acid catabolic process","ATP binding;CoA carboxylase activity;propionyl-CoA carboxylase activity","cytosol;mitochondrial matrix;mitochondrion","Carbon metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,16,16,16,"41.6","41.6","41.6","58.215",0,"174.52",702390000,47,"0.44248",1,"0.76473","1.03049","sp|P05166|PCCB_HUMAN;tr|E9PDR0|E9PDR0_HUMAN;tr|E7EX59|E7EX59_HUMAN;tr|E7EUY3|E7EUY3_HUMAN;tr|E7ETT1|E7ETT1_HUMAN;tr|C9JQS9|C9JQS9_HUMAN;tr|E7ETT4|E7ETT4_HUMAN;tr|E9PEC3|E9PEC3_HUMAN;tr|F8WBI9|F8WBI9_HUMAN;tr|E7ENC1|E7ENC1_HUMAN;tr|H7C5C9|H7C5C9_HUMAN;tr|C9JVW9|C9JVW9_HUMAN;tr|C9JAW3|C9JAW3_HUMAN;tr|C9JVY9|C9JVY9_HUMAN","sp|P05166|PCCB_HUMAN;tr|E9PDR0|E9PDR0_HUMAN;tr|E7EX59|E7EX59_HUMAN;tr|E7EUY3|E7EUY3_HUMAN;tr|E7ETT1|E7ETT1_HUMAN;tr|C9JQS9|C9JQS9_HUMAN;tr|E7ETT4|E7ETT4_HUMAN;tr|E9PEC3|E9PEC3_HUMAN;tr|F8WBI9|F8WBI9_HUMAN",898,"P05166","PCCB_HUMAN","Propionyl-CoA carboxylase beta chain, mitochondrial","CCase subunit beta","PCCB"]
["21.6054","19.7642","20.9715","20.3489","19.1344","20.5652",{"$nulls":3},"adherens junction organization;cell-cell adhesion;cellular response to indole-3-methanol;cellular response to lithium ion;entry of bacterium into host cell;extracellular matrix disassembly;extracellular matrix organization;homophilic cell adhesion via plasma membrane adhesion molecules;negative regulation of cell-cell adhesion;neuron projection development;pituitary gland development;positive regulation of transcription factor import into nucleus;positive regulation of transcription, DNA-templated;protein localization to plasma membrane;response to drug;response to toxic substance;synapse assembly","ankyrin binding;beta-catenin binding;cadherin binding;calcium ion binding;cell adhesion molecule binding;gamma-catenin binding;GTPase activating protein binding;identical protein binding","actin cytoskeleton;apical junction complex;catenin complex;cell junction;cell-cell adherens junction;cytoplasmic side of plasma membrane;endosome;extracellular exosome;extracellular region;flotillin complex;integral component of membrane;lamellipodium;lateral plasma membrane;perinuclear region of cytoplasm;plasma membrane;trans-Golgi network","Adherens junction;Apelin signaling pathway;Bacterial invasion of epithelial cells;Bladder cancer;Cell adhesion molecules (CAMs);Endometrial cancer;Gastric cancer;Hippo signaling pathway;Melanoma;Pathogenic Escherichia coli infection;Pathways in cancer;Rap1 signaling pathway;Thyroid cancer",null,null,13,12,12,"24.5","23.7","23.7","97.455",0,"128.1",510780000,50,"0.473297",1,"0.7642","1.09178","sp|P12830|CADH1_HUMAN;tr|A0A087WXI5|A0A087WXI5_HUMAN;tr|A0A087WX17|A0A087WX17_HUMAN;tr|A0A087WU43|A0A087WU43_HUMAN;tr|H3BNC6|H3BNC6_HUMAN;tr|H3BVI7|H3BVI7_HUMAN;tr|J3QKP1|J3QKP1_HUMAN","sp|P12830|CADH1_HUMAN;tr|A0A087WXI5|A0A087WXI5_HUMAN;tr|A0A087WX17|A0A087WX17_HUMAN;tr|A0A087WU43|A0A087WU43_HUMAN",1070,"P12830","CADH1_HUMAN","Cadherin-1",null,"CDH1"]
["23.7647","21.5552","21.9011","21.7947","20.951","22.1857",{"$nulls":3},"error-free translesion synthesis;Golgi organization;negative regulation of RIG-I signaling pathway;negative regulation of type I interferon production;retrograde protein transport, ER to cytosol;ubiquitin-dependent ERAD pathway;ubiquitin-dependent protein catabolic process","metal ion binding;ubiquitin binding;ubiquitin protein ligase binding","cytosol;endoplasmic reticulum;nuclear outer membrane-endoplasmic reticulum membrane network;nucleoplasm;nucleus;UFD1-NPL4 complex;VCP-NPL4-UFD1 AAA ATPase complex","Protein processing in endoplasmic reticulum",null,null,25,25,25,"54.4","54.4","54.4","68.119",0,"226.58",1376300000,93,"0.418513",1,"0.763235","0.982469","sp|Q8TAT6|NPL4_HUMAN;tr|I3L4U9|I3L4U9_HUMAN;tr|A0A0D9SFI9|A0A0D9SFI9_HUMAN;tr|I3L3I1|I3L3I1_HUMAN;tr|I3L283|I3L283_HUMAN;tr|I3L281|I3L281_HUMAN","sp|Q8TAT6|NPL4_HUMAN",3532,"Q8TAT6","NPL4_HUMAN","Nuclear protein localization protein 4 homolog","rotein NPL4","NPLOC4"]
["19.7771","18.5878","19.1582","19.236","16.6143","19.3838",{"$nulls":3},"spliceosomal tri-snRNP complex assembly",null,"spliceosomal complex",{"$nulls":3},9,9,9,"34.6","34.6","34.6","43.472",0,"45.783",354690000,37,"0.325639",1,"0.763017","0.792434","sp|Q9Y312|AAR2_HUMAN;tr|A2A2Q9|A2A2Q9_HUMAN","sp|Q9Y312|AAR2_HUMAN;tr|A2A2Q9|A2A2Q9_HUMAN",5262,"Q9Y312","AAR2_HUMAN","Protein AAR2 homolog",null,"AAR2"]
["18.7586","17.358","16.3594","18.6184","16.5914","14.9789",{"$nulls":3},"mRNA 3'-end processing;mRNA 3'-end processing by stem-loop binding and cleavage;mRNA cleavage;mRNA export from nucleus;mRNA polyadenylation;mRNA splicing, via spliceosome;termination of RNA polymerase II transcription","5'-3' exonuclease activity;endoribonuclease activity;metal ion binding;RNA binding","intracellular ribonucleoprotein complex;mRNA cleavage and polyadenylation specificity factor complex;nucleoplasm","mRNA surveillance pathway",null,null,10,10,10,18,18,18,"77.485",0,"22.839",148650000,25,"0.23781",1,"0.762441","0.604127","sp|Q9UKF6|CPSF3_HUMAN;tr|G5E9W3|G5E9W3_HUMAN;tr|C9JZH6|C9JZH6_HUMAN","sp|Q9UKF6|CPSF3_HUMAN;tr|G5E9W3|G5E9W3_HUMAN",5087,"Q9UKF6","CPSF3_HUMAN","Cleavage and polyadenylation specificity factor subunit 3",null,"CPSF3"]
["23.1021","20.4956","22.0125","21.266","20.4405","21.6203",{"$nulls":3},"negative regulation of ATP citrate synthase activity;negative regulation of lyase activity;negative regulation of T cell receptor signaling pathway;peptidyl-histidine dephosphorylation;positive regulation of cell motility;positive regulation of insulin secretion involved in cellular response to glucose stimulus;protein dephosphorylation;regulation of actin cytoskeleton reorganization","calcium channel inhibitor activity;ion channel binding;protein histidine phosphatase activity","cytosol;extracellular exosome",{"$nulls":3},4,4,4,"51.2","51.2","51.2","13.832",0,"30.487",234840000,22,"0.384671",1,"0.761104","0.914037","sp|Q9NRX4|PHP14_HUMAN","sp|Q9NRX4|PHP14_HUMAN",4703,"Q9NRX4","PHP14_HUMAN","14 kDa phosphohistidine phosphatase {ECO:0000303|PubMed:12383260}",null,"PHPT1"]
["18.428","16.5555","17.6848","17.5899","15.6618","17.1379",{"$nulls":3},"cell chemotaxis;cobalamin metabolic process;drug transmembrane transport;glutathione transmembrane transport;leukotriene metabolic process;phospholipid translocation;response to drug;sphingolipid translocation;transmembrane transport;transport;xenobiotic transport","ATP binding;ATPase activity;ATPase activity, coupled to transmembrane movement of substances;ATPase-coupled anion transmembrane transporter activity;cobalamin-transporting ATPase activity;glutathione S-conjugate-exporting ATPase activity;glutathione transmembrane transporter activity;phospholipid-translocating ATPase activity;sphingolipid-translocating ATPase activity;transporter activity;xenobiotic transmembrane transporting ATPase activity","basolateral plasma membrane;extracellular exosome;integral component of plasma membrane;membrane;plasma membrane","ABC transporters;Antifolate resistance;MicroRNAs in cancer;Sphingolipid signaling pathway;Vitamin digestion and absorption",null,null,10,10,10,"9.9","9.9","9.9","171.59",0,"24.939",139890000,16,"0.403901",1,"0.759564","0.953019","sp|P33527|MRP1_HUMAN;tr|I3L4X2|I3L4X2_HUMAN;tr|A0A0A0MS99|A0A0A0MS99_HUMAN","sp|P33527|MRP1_HUMAN;tr|I3L4X2|I3L4X2_HUMAN;tr|A0A0A0MS99|A0A0A0MS99_HUMAN",1434,"P33527","MRP1_HUMAN","Multidrug resistance-associated protein 1",null,"ABCC1"]
["27.2675","26.1203","26.519","26.6345","24.6397","26.359",{"$nulls":3},"anion transport;apoptotic process;behavioral fear response;epithelial cell differentiation;learning;macroautophagy;mitochondrial calcium ion transmembrane transport;negative regulation of reactive oxygen species metabolic process;neuron-neuron synaptic transmission;regulation of autophagy of mitochondrion;viral process","identical protein binding;ion channel binding;porin activity;protein complex binding;protein kinase binding;voltage-gated anion channel activity","extracellular exosome;membrane;membrane raft;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrial outer membrane;mitochondrial permeability transition pore complex;mitochondrion;myelin sheath;nucleus;plasma membrane;pore complex;synaptic vesicle","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholesterol metabolism;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Necroptosis;NOD-like receptor signaling pathway;Parkinson disease",null,null,19,19,19,"80.6","80.6","80.6","30.772",0,"323.31",13899000000,376,"0.461837",1,"0.75787","1.06904","sp|P21796|VDAC1_HUMAN;tr|C9JI87|C9JI87_HUMAN","sp|P21796|VDAC1_HUMAN;tr|C9JI87|C9JI87_HUMAN",1232,"P21796","VDAC1_HUMAN","Voltage-dependent anion-selective channel protein 1","DAC-1;VDAC1","VDAC1"]
["21.1584","18.7165","20.2657","19.6678","17.9767","20.224",{"$nulls":3},"mRNA splicing, via spliceosome;protein folding","peptidyl-prolyl cis-trans isomerase activity","catalytic step 2 spliceosome;nucleoplasm",{"$nulls":3},7,7,7,"28.4","28.4","28.4","53.846",0,"73.963",173380000,11,"0.315296",1,"0.757381","0.770775","sp|Q6UX04|CWC27_HUMAN;tr|D6REK3|D6REK3_HUMAN","sp|Q6UX04|CWC27_HUMAN;tr|D6REK3|D6REK3_HUMAN",3060,"Q6UX04","CWC27_HUMAN","Peptidyl-prolyl cis-trans isomerase CWC27 homolog","PIase CWC27","CWC27"]
["17.9399","17.3499","17.4527","15.5827","16.8538","18.0339",{"$nulls":3},"negative regulation of transcription, DNA-templated;regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding;methyl-CpG binding","cytosol;nucleoplasm;nucleus",{"$nulls":3},13,13,13,"20.4","20.4","20.4","118.87",0,"52.546",350570000,47,"0.445432",1,"0.757357","1.03638","sp|Q9ULJ3|ZBT21_HUMAN;tr|E7EVF9|E7EVF9_HUMAN","sp|Q9ULJ3|ZBT21_HUMAN",5124,"Q9ULJ3","ZBT21_HUMAN","Zinc finger and BTB domain-containing protein 21",null,"ZBTB21"]
["22.3873","20.947","21.767","21.3093","20.3251","21.1954",{"$nulls":3},"cellular response to DNA damage stimulus;protein de-ADP-ribosylation;purine nucleoside metabolic process","deacetylase activity;hydrolase activity, acting on glycosyl bonds","mitochondrion;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"25.8","25.8","25.8","35.505",0,"46.717",359250000,19,"0.659146",1,"0.757186","1.4556","sp|Q9BQ69|MACD1_HUMAN","sp|Q9BQ69|MACD1_HUMAN",4139,"Q9BQ69","MACD1_HUMAN","O-acetyl-ADP-ribose deacetylase MACROD1",null,"MACROD1"]
[18,"15.1105","15.8002","15.9431","15.3853","15.3144",{"$nulls":3},"cell proliferation;DNA dealkylation involved in DNA repair;DNA duplex unwinding;regulation of transcription, DNA-templated;transcription, DNA-templated","ATP binding;ATP-dependent 3'-5' DNA helicase activity;RNA binding","activating signal cointegrator 1 complex;cytosol;intracellular;membrane;nucleoplasm;nucleus",{"$nulls":3},12,12,12,"6.8","6.8","6.8","251.46",0,"26.837",154840000,18,"0.351392",1,"0.755926","0.845878","sp|Q8N3C0|ASCC3_HUMAN;tr|E5RFZ0|E5RFZ0_HUMAN;tr|J3KNJ4|J3KNJ4_HUMAN","sp|Q8N3C0|ASCC3_HUMAN",3389,"Q8N3C0","ASCC3_HUMAN","Activating signal cointegrator 1 complex subunit 3",null,"ASCC3"]
["22.3725","21.2902","20.9481","21.2888","19.7031","21.3528",{"$nulls":3},"circadian rhythm;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;sodium ion transport;ubiquinone-6 biosynthetic process","coenzyme binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity;protein complex binding","mitochondrial matrix;mitochondrial membrane;mitochondrial respiratory chain complex I;mitochondrion;nucleoplasm;nucleus","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,17,17,17,"48.8","48.8","48.8","42.509",0,"70.075",920230000,65,"0.475215",1,"0.755401","1.09558","sp|Q16795|NDUA9_HUMAN;tr|F5H0J3|F5H0J3_HUMAN;tr|H3BRM9|H3BRM9_HUMAN;tr|F5GY40|F5GY40_HUMAN","sp|Q16795|NDUA9_HUMAN",2696,"Q16795","NDUA9_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial",null,"NDUFA9"]
["17.8585","16.5717","18.0153","16.4181","16.1911","17.5705",{"$nulls":3},"cellular response to DNA damage stimulus;chromatin remodeling;covalent chromatin modification;negative regulation of DNA damage checkpoint;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;regulation of inflammatory response;regulation of phosphorylation of RNA polymerase II C-terminal domain;regulation of transcription involved in G1/S transition of mitotic cell cycle;transcription, DNA-templated;viral process","chromatin binding;lysine-acetylated histone binding;p53 binding;RNA polymerase II core binding","chromosome;condensed nuclear chromosome;cytosol;nucleoplasm;nucleus",{"$nulls":3},7,4,3,"5.4",4,"3.4","152.22",0,"9.3694",112750000,15,"0.531778",1,"0.755222","1.20703","sp|O60885|BRD4_HUMAN","sp|O60885|BRD4_HUMAN",535,"O60885","BRD4_HUMAN","Bromodomain-containing protein 4",null,"BRD4"]
["20.5716","19.5598","20.1165","19.4595","19.251","19.272",{"$nulls":3},"establishment of integrated proviral latency;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;negative regulation of viral genome replication;nuclear transport;response to virus","DNA binding;enzyme binding;identical protein binding;LEM domain binding;protein C-terminus binding;protein homodimerization activity;protein N-terminus binding","chromosome;cytoplasm;cytosol;extracellular exosome;nuclear envelope;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"29.2","29.2","29.2","10.058",0,"19.303",83184000,10,"1.18351",1,"0.755182","2.51741","sp|O75531|BAF_HUMAN","sp|O75531|BAF_HUMAN",604,"O75531","BAF_HUMAN","Barrier-to-autointegration factor",null,"BANF1"]
["25.9994","24.8404","25.4653","25.2113","24.0813","24.7472",{"$nulls":3},"2-oxoglutarate metabolic process;4-hydroxyproline catabolic process;aspartate biosynthetic process;aspartate catabolic process;aspartate metabolic process;cellular amino acid biosynthetic process;fatty acid transport;gluconeogenesis;glutamate catabolic process to 2-oxoglutarate;glutamate catabolic process to aspartate;glutamate metabolic process;glyoxylate metabolic process;oxaloacetate metabolic process;response to ethanol","4-hydroxyglutamate transaminase activity;amino acid binding;enzyme binding;kynurenine-oxoglutarate transaminase activity;L-aspartate:2-oxoglutarate aminotransferase activity;L-phenylalanine:2-oxoglutarate aminotransferase activity;phospholipid binding;protein homodimerization activity;pyridoxal phosphate binding;RNA binding","cell surface;extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;myelin sheath;perikaryon;plasma membrane;protein complex","2-Oxocarboxylic acid metabolism;Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Fat digestion and absorption;Metabolic pathways;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Tyrosine metabolism",null,null,24,24,24,"64.7","64.7","64.7","47.517",0,"323.31",8774700000,238,"0.73873",1,"0.755071","1.61085","sp|P00505|AATM_HUMAN","sp|P00505|AATM_HUMAN",830,"P00505","AATM_HUMAN","Aspartate aminotransferase, mitochondrial","AspAT","GOT2"]
["22.5274","21.3655","22.1398","21.4872","20.4805","21.801",{"$nulls":3},"activation of MAPKK activity;adenosine receptor signaling pathway;adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;cell cycle;cell division;cell proliferation;gamma-aminobutyric acid signaling pathway;G-protein coupled acetylcholine receptor signaling pathway;G-protein coupled receptor signaling pathway;intracellular signal transduction;negative regulation of adenylate cyclase activity;negative regulation of synaptic transmission;positive regulation of cell proliferation;protein folding;regulation of calcium ion transport;response to nutrient;signal transduction","G-protein beta/gamma-subunit complex binding;G-protein coupled receptor binding;GTP binding;GTPase activity;metal ion binding;signal transducer activity","cell body;centrosome;cytoplasm;cytosol;dendrite;extracellular exosome;extracellular vesicle;heterotrimeric G-protein complex;membrane;membrane raft;midbody;nucleoplasm;plasma membrane","Adrenergic signaling in cardiomyocytes;Alcoholism;Apelin signaling pathway;Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Leukocyte transendothelial migration;Long-term depression;Melanogenesis;Morphine addiction;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Serotonergic synapse;Sphingolipid signaling pathway;Toxoplasmosis",null,null,13,13,8,"44.8","44.8","29.9","40.45",0,"86.077",948290000,67,"0.650235",1,"0.754654","1.43825","sp|P04899|GNAI2_HUMAN;sp|P11488|GNAT1_HUMAN;sp|P19087|GNAT2_HUMAN;sp|A8MTJ3|GNAT3_HUMAN;tr|A0A087WTB6|A0A087WTB6_HUMAN;tr|A2A2R6|A2A2R6_HUMAN;tr|Q5JWD1|Q5JWD1_HUMAN;tr|H0Y7E8|H0Y7E8_HUMAN;tr|A0A087WZE5|A0A087WZE5_HUMAN;sp|P38405|GNAL_HUMAN","sp|P04899|GNAI2_HUMAN",884,"P04899","GNAI2_HUMAN","Guanine nucleotide-binding protein G(i) subunit alpha-2",null,"GNAI2"]
["20.3928","18.5776","20.2836","19.2007","17.8664","19.9231",{"$nulls":3},"protein import into mitochondrial matrix;protein targeting to mitochondrion","P-P-bond-hydrolysis-driven protein transmembrane transporter activity;protein channel activity","integral component of mitochondrial inner membrane;mitochondrial inner membrane;mitochondrial inner membrane presequence translocase complex;mitochondrial intermembrane space;mitochondrion",{"$nulls":3},2,2,2,"27.8","27.8","27.8","21.943",0,"13.819",90256000,10,"0.376126",1,"0.754608","0.896625","sp|O14925|TIM23_HUMAN;sp|Q5SRD1|TI23B_HUMAN;tr|B4DDK6|B4DDK6_HUMAN","sp|O14925|TIM23_HUMAN;sp|Q5SRD1|TI23B_HUMAN;tr|B4DDK6|B4DDK6_HUMAN",309,"O14925","TIM23_HUMAN","Mitochondrial import inner membrane translocase subunit Tim23",null,"TIMM23"]
["23.6824","22.6531","22.5664","22.6817","21.9769","21.9865",{"$nulls":3},"angiotensin maturation;COPII vesicle coating;epithelial tube branching involved in lung morphogenesis;ER to Golgi vesicle-mediated transport;negative regulation of neuron projection development;negative regulation of plasminogen activation;negative regulation of protein binding;neutrophil degranulation;positive regulation of neural precursor cell proliferation;positive regulation of neuron apoptotic process;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of neuron death","carboxypeptidase activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity","cell cortex region;cell surface;COPII-coated ER to Golgi transport vesicle;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;Golgi membrane;growth cone;intracellular membrane-bounded organelle;lysosome;plasma membrane;specific granule lumen","Apoptosis;Lysosome",null,null,6,6,6,"27.1","27.1","27.1","33.868",0,"43.626",591690000,21,"0.814117",1,"0.752266","1.75886","sp|Q9UBR2|CATZ_HUMAN","sp|Q9UBR2|CATZ_HUMAN",4971,"Q9UBR2","CATZ_HUMAN","Cathepsin Z",null,"CTSZ"]
["17.7253","14.7504","16.0337","15.0427","15.6077","15.6033",{"$nulls":3},"N-terminal protein myristoylation","glycylpeptide N-tetradecanoyltransferase activity","cytosol;Golgi apparatus;plasma membrane",{"$nulls":3},4,2,2,"10.1","5.8","5.8","56.716","0.0011811","3.3221",27822000,2,"0.354784",1,"0.751944","0.85287","tr|Q5VUC6|Q5VUC6_HUMAN;sp|O60551|NMT2_HUMAN","tr|Q5VUC6|Q5VUC6_HUMAN;sp|O60551|NMT2_HUMAN",504,"Q5VUC6","Q5VUC6_HUMAN","Glycylpeptide N-tetradecanoyltransferase {ECO:0000256|RuleBase:RU000586}"]
["20.6108","18.8852","18.5655","19.4169","17.9579","18.4316",{"$nulls":3},"post-translational protein modification;protein ubiquitination",null,"Cul4-RING E3 ubiquitin ligase complex;cytoplasm;cytosol;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},9,9,9,"16.8","16.8","16.8","66.851",0,"20.177",171570000,13,"0.417362",1,"0.75171","0.980154","sp|Q5TAQ9|DCAF8_HUMAN;tr|G3V3G9|G3V3G9_HUMAN;tr|V9GY54|V9GY54_HUMAN;tr|Q5TAQ8|Q5TAQ8_HUMAN","sp|Q5TAQ9|DCAF8_HUMAN;tr|G3V3G9|G3V3G9_HUMAN;tr|V9GY54|V9GY54_HUMAN",2881,"Q5TAQ9","DCAF8_HUMAN","DDB1- and CUL4-associated factor 8",null,"DCAF8"]
["25.1642","24.1484","24.058","24.3264","23.272","23.5174",{"$nulls":3},"G-quadruplex DNA unwinding;interleukin-12-mediated signaling pathway;miRNA transport;mRNA export from nucleus;mRNA processing;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;negative regulation of transcription from RNA polymerase II promoter;positive regulation of telomerase RNA reverse transcriptase activity;positive regulation of telomere maintenance via telomere lengthening;primary miRNA processing;RNA metabolic process;RNA transport","G-rich strand telomeric DNA binding;identical protein binding;miRNA binding;mRNA 3'-UTR binding;N6-methyladenosine-containing RNA binding;pre-mRNA intronic binding;RNA binding;single-stranded telomeric DNA binding","Cajal body;catalytic step 2 spliceosome;chromosome, telomeric region;cytoplasm;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nuclear matrix;nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},18,18,17,"54.4","54.4","54.4","37.429",0,"218.49",3709600000,174,"0.72129",1,"0.751608","1.57676","sp|P22626|ROA2_HUMAN;tr|A0A087WUI2|A0A087WUI2_HUMAN","sp|P22626|ROA2_HUMAN;tr|A0A087WUI2|A0A087WUI2_HUMAN",1248,"P22626","ROA2_HUMAN","Heterogeneous nuclear ribonucleoproteins A2/B1","nRNP A2/B1","HNRNPA2B1"]
["22.1403","20.6108","21.0228","21.2604","20.0674","20.1936",{"$nulls":3},"activation of innate immune response;innate immune response;posttranscriptional regulation of gene expression","identical protein binding;miRNA binding;RNA binding;structural molecule activity;zinc ion binding","membrane;nuclear inner membrane;nuclear matrix",{"$nulls":3},18,18,18,"33.4","33.4","33.4","94.622",0,"260.64",938920000,90,"0.561708",1,"0.750855","1.26564","sp|P43243|MATR3_HUMAN;tr|A8MXP9|A8MXP9_HUMAN;tr|D6REM6|D6REM6_HUMAN;tr|D6R991|D6R991_HUMAN;tr|B3KM87|B3KM87_HUMAN;tr|H0Y8T4|H0Y8T4_HUMAN;tr|Q68E03|Q68E03_HUMAN;tr|D6RBI2|D6RBI2_HUMAN;tr|D6RE02|D6RE02_HUMAN;tr|D6RIA2|D6RIA2_HUMAN;tr|D6RB45|D6RB45_HUMAN;tr|A0A0K0K1G4|A0A0K0K1G4_HUMAN;tr|D6R9F3|D6R9F3_HUMAN;tr|D6RAM9|D6RAM9_HUMAN;tr|D6RAY2|D6RAY2_HUMAN;tr|D6RBS2|D6RBS2_HUMAN;tr|D6RCM3|D6RCM3_HUMAN;tr|D6REK4|D6REK4_HUMAN;tr|D6R8Z5|D6R8Z5_HUMAN;tr|D6RBK5|D6RBK5_HUMAN","sp|P43243|MATR3_HUMAN;tr|A8MXP9|A8MXP9_HUMAN;tr|D6REM6|D6REM6_HUMAN;tr|D6R991|D6R991_HUMAN;tr|B3KM87|B3KM87_HUMAN",1567,"P43243","MATR3_HUMAN","Matrin-3",null,"MATR3"]
["22.1224","21.6755","23.0306","21.6994","20.0047","22.872",{"$nulls":3},"endothelial cell differentiation;multicellular organism development;positive regulation of DNA binding;positive regulation of transcription, DNA-templated;regulation of lipid metabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated","calmodulin binding;RNA binding;sequence-specific DNA binding;transcription coactivator activity","cytoplasm;cytosol;extracellular exosome;intracellular;nucleolus;nucleus",{"$nulls":3},5,5,5,"28.4","28.4","28.4","16.368",0,"65.652",384120000,32,"0.335791",1,"0.750809","0.813581","sp|O60869|EDF1_HUMAN","sp|O60869|EDF1_HUMAN",531,"O60869","EDF1_HUMAN","Endothelial differentiation-related factor 1","DF-1","EDF1"]
["19.8311","16.841","17.698","18.2829","16.1614","17.6743",{"$nulls":3},"autophagosome assembly;autophagy of mitochondrion;autophagy of nucleus;macroautophagy;protein lipidation;protein lipidation involved in autophagosome assembly;protein localization to phagophore assembly site;xenophagy","phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-3-phosphate binding;phosphatidylinositol-5-phosphate binding","cytosol;extrinsic component of membrane;phagophore assembly site;phagophore assembly site membrane;protein complex","Autophagy - animal;Autophagy - other",null,null,2,2,2,15,15,15,"49.408",0,"21.914",42475000,9,"0.276557",1,"0.750467","0.68851","sp|Q9Y4P8|WIPI2_HUMAN","sp|Q9Y4P8|WIPI2_HUMAN",5332,"Q9Y4P8","WIPI2_HUMAN","WD repeat domain phosphoinositide-interacting protein 2","IPI-2","WIPI2"]
["29.0984","27.5832","27.9621","28.074","26.8394","27.4806",{"$nulls":3},"animal organ regeneration;cellular response to cell-matrix adhesion;cellular response to epidermal growth factor stimulus;cellular response to glucocorticoid stimulus;cellular response to insulin stimulus;cellular response to lipopolysaccharide;cellular response to oxidative stress;central nervous system development;common myeloid progenitor cell proliferation;glutathione derivative biosynthetic process;glutathione metabolic process;linoleic acid metabolic process;negative regulation of acute inflammatory response;negative regulation of apoptotic process;negative regulation of biosynthetic process;negative regulation of ERK1 and ERK2 cascade;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of fibroblast proliferation;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interleukin-1 beta production;negative regulation of JUN kinase activity;negative regulation of leukocyte proliferation;negative regulation of MAP kinase activity;negative regulation of MAPK cascade;negative regulation of monocyte chemotactic protein-1 production;negative regulation of nitric-oxide synthase biosynthetic process;negative regulation of protein kinase activity;negative regulation of smooth muscle cell chemotaxis;negative regulation of stress-activated MAPK cascade;negative regulation of tumor necrosis factor production;negative regulation of tumor necrosis factor-mediated signaling pathway;negative regulation of vascular smooth muscle cell proliferation;neutrophil degranulation;nitric oxide storage;oligodendrocyte development;positive regulation of superoxide anion generation;regulation of ERK1 and ERK2 cascade;regulation of stress-activated MAPK cascade;response to amino acid;response to estradiol;response to ethanol;response to L-ascorbic acid;response to reactive oxygen species;xenobiotic metabolic process","dinitrosyl-iron complex binding;drug binding;glutathione binding;glutathione peroxidase activity;glutathione transferase activity;JUN kinase binding;kinase regulator activity;nitric oxide binding;S-nitrosoglutathione binding","cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;intracellular;mitochondrion;nucleus;plasma membrane;secretory granule lumen;TRAF2-GSTP1 complex;vesicle","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Fluid shear stress and atherosclerosis;Glutathione metabolism;Hepatocellular carcinoma;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pathways in cancer;Platinum drug resistance;Prostate cancer",null,null,12,12,12,"58.1","58.1","58.1","23.356",0,"323.31",29503000000,293,"0.577705",1,"0.749875","1.29689","sp|P09211|GSTP1_HUMAN;tr|A8MX94|A8MX94_HUMAN;tr|A0A087X2E9|A0A087X2E9_HUMAN;tr|A0A087X243|A0A087X243_HUMAN","sp|P09211|GSTP1_HUMAN;tr|A8MX94|A8MX94_HUMAN",984,"P09211","GSTP1_HUMAN","Glutathione S-transferase P",null,"GSTP1"]
["18.0582","17.3889","17.2296","16.8295","16.9036","16.6963",{"$nulls":3},"cellular response to DNA damage stimulus;DNA replication;embryonic organ development;in utero embryonic development;mRNA processing;multicellular organism growth;protein polyubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of DNA replication;somite development","protein kinase binding;RNA binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity;zinc ion binding","chromosome;cytosol;microtubule organizing center;nucleolus;protein complex",{"$nulls":3},10,10,10,"7.4","7.4","7.4","201.56",0,"31.128",310170000,38,"1.34241",1,"0.749107","2.87028","sp|Q7Z6E9|RBBP6_HUMAN;tr|H3BUN0|H3BUN0_HUMAN;tr|I3L3Y2|I3L3Y2_HUMAN;tr|H3BSK8|H3BSK8_HUMAN;tr|A0A087WY32|A0A087WY32_HUMAN","sp|Q7Z6E9|RBBP6_HUMAN;tr|H3BUN0|H3BUN0_HUMAN",3182,"Q7Z6E9","RBBP6_HUMAN","E3 ubiquitin-protein ligase RBBP6",null,"RBBP6"]
["21.8926","20.6512","21.0066","20.1504","20.3304","20.8262",{"$nulls":3},"positive regulation of core promoter binding;positive regulation of viral transcription;regulation of transcription, DNA-templated;RNA polymerase II transcriptional preinitiation complex assembly;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;viral process","core promoter binding;metal ion binding;TBP-class protein binding;thyroid hormone receptor binding;transcription factor binding","nuclear body;nucleoplasm;nucleus;transcription factor TFIID complex;transcriptional preinitiation complex","Basal transcription factors;Viral carcinogenesis",null,null,12,12,12,"51.6","51.6","51.6","34.833",0,"68.697",466880000,51,"0.823386",1,"0.747815","1.77716","sp|Q00403|TF2B_HUMAN;tr|B1APE1|B1APE1_HUMAN;tr|B1APE2|B1APE2_HUMAN","sp|Q00403|TF2B_HUMAN;tr|B1APE1|B1APE1_HUMAN",2116,"Q00403","TF2B_HUMAN","Transcription initiation factor IIB",null,"GTF2B"]
["21.3345","20.0129","20.7563","19.9893","19.6286","20.2439",{"$nulls":3},"intracellular protein transport;vesicle-mediated transport","lipid binding","clathrin adaptor complex;plasma membrane",{"$nulls":3},13,13,13,"38.9","38.9","38.9","49.526",0,"71.285",1110400000,74,"0.820001",1,"0.747318","1.77047","tr|A0A087WY71|A0A087WY71_HUMAN;sp|Q96CW1|AP2M1_HUMAN;tr|E9PFW3|E9PFW3_HUMAN;tr|C9JJ47|C9JJ47_HUMAN;tr|C9JTK4|C9JTK4_HUMAN;tr|C9JGT8|C9JGT8_HUMAN;tr|C9JJD3|C9JJD3_HUMAN;tr|C9JPV8|C9JPV8_HUMAN;tr|H7C4C3|H7C4C3_HUMAN","tr|A0A087WY71|A0A087WY71_HUMAN;sp|Q96CW1|AP2M1_HUMAN;tr|E9PFW3|E9PFW3_HUMAN;tr|C9JJ47|C9JJ47_HUMAN",3832,"A0A087WY71","A0A087WY71_HUMAN",null,null,"AP2M1"]
["18.5861","19.5913","19.0794","18.4327","18.5507","18.0354",{"$nulls":3},"biotin metabolic process;short-chain fatty acid catabolic process","ATP binding;biotin binding;biotin carboxylase activity;enzyme binding;metal ion binding;propionyl-CoA carboxylase activity","cytosol;mitochondrial matrix","Carbon metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,29,29,29,"45.1","45.1","45.1","80.058",0,"102.27",772970000,58,"1.06428",1,"0.745996","2.26458","sp|P05165|PCCA_HUMAN;tr|H0Y5U0|H0Y5U0_HUMAN;tr|Q5JTW6|Q5JTW6_HUMAN;tr|Q5JVH2|Q5JVH2_HUMAN;tr|H0Y4B9|H0Y4B9_HUMAN;tr|H0Y798|H0Y798_HUMAN","sp|P05165|PCCA_HUMAN",897,"P05165","PCCA_HUMAN","Propionyl-CoA carboxylase alpha chain, mitochondrial","CCase subunit alpha","PCCA"]
["23.5727","22.2391","22.5445","22.3667","20.8845","22.8699",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,6,6,6,"46.2","46.2","46.2","12.517",0,"17.929",386770000,18,"0.444959",1,"0.745083","1.03544","sp|O43920|NDUS5_HUMAN","sp|O43920|NDUS5_HUMAN",472,"O43920","NDUS5_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 5",null,"NDUFS5"]
["22.6503","22.1224","21.7048","21.5815","21.2603","21.4048",{"$nulls":3},"protein targeting to ER;signal peptide processing","peptidase activity","endoplasmic reticulum membrane;integral component of membrane;organelle membrane;signal peptidase complex","Protein export",null,null,7,7,7,"35.8","35.8","35.8","25.003",0,111,500070000,25,"1.20959",1,"0.743598","2.57398","sp|Q15005|SPCS2_HUMAN;tr|A0A087WUC6|A0A087WUC6_HUMAN;tr|E9PI68|E9PI68_HUMAN;tr|E9PL01|E9PL01_HUMAN;tr|E9PRB9|E9PRB9_HUMAN;tr|H0YE04|H0YE04_HUMAN","sp|Q15005|SPCS2_HUMAN;tr|A0A087WUC6|A0A087WUC6_HUMAN;tr|E9PI68|E9PI68_HUMAN;tr|E9PL01|E9PL01_HUMAN;tr|E9PRB9|E9PRB9_HUMAN",2531,"Q15005","SPCS2_HUMAN","Signal peptidase complex subunit 2",null,"SPCS2"]
["19.0229","16.4959","18.4946","18.2996","15.5131","17.9713",{"$nulls":4},"RNA binding","mitochondrion",{"$nulls":3},3,3,3,"13.4","13.4","13.4","49.996",0,"12.264",51071000,9,"0.252334",1,"0.743167","0.636031","sp|Q96I51|WBS16_HUMAN;tr|A0A087WT38|A0A087WT38_HUMAN","sp|Q96I51|WBS16_HUMAN",3923,"Q96I51","RCC1L_HUMAN","RCC1-like G exchanging factor-like protein","CC1 like","RCC1L"]
["19.7637","15.5247","18.1884","18.0648","14.3482","18.8349",{"$nulls":3},"activation of store-operated calcium channel activity;cellular calcium ion homeostasis;detection of calcium ion;enamel mineralization;positive regulation of angiogenesis;regulation of calcium ion transport;regulation of cardiac conduction;regulation of store-operated calcium entry;store-operated calcium entry","calcium channel regulator activity;calcium ion binding;identical protein binding;microtubule plus-end binding;protease binding","cortical endoplasmic reticulum;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;integral component of plasma membrane;microtubule;plasma membrane;sarcoplasmic reticulum membrane","Calcium signaling pathway;Platelet activation",null,null,8,8,8,18,18,18,"77.422",0,"20.625",122490000,16,"0.14902",1,"0.743003","0.400076","sp|Q13586|STIM1_HUMAN;tr|G0XQ39|G0XQ39_HUMAN;tr|E9PNJ4|E9PNJ4_HUMAN;tr|H0YDB2|H0YDB2_HUMAN;tr|E9PIQ8|E9PIQ8_HUMAN;tr|E9PRE4|E9PRE4_HUMAN;tr|E9PR07|E9PR07_HUMAN;tr|E9PJ19|E9PJ19_HUMAN;tr|E9PMB4|E9PMB4_HUMAN;tr|E9PRZ7|E9PRZ7_HUMAN;tr|E9PR09|E9PR09_HUMAN;tr|E9PN27|E9PN27_HUMAN","sp|Q13586|STIM1_HUMAN;tr|G0XQ39|G0XQ39_HUMAN;tr|E9PNJ4|E9PNJ4_HUMAN;tr|H0YDB2|H0YDB2_HUMAN",2386,"Q13586","STIM1_HUMAN","Stromal interaction molecule 1",null,"STIM1"]
["19.4065","18.8003","16.9528","18.7454","17.897","16.289",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;cell proliferation;mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K11-linked ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of mitotic nuclear division;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle",null,"anaphase-promoting complex;centrosome;cytoplasm;cytosol;nucleoplasm;spindle","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis",null,null,7,7,7,"14.2","14.2","14.2","71.655",0,"16.371",123150000,22,"0.291392",1,"0.742722","0.720237","sp|Q13042|CDC16_HUMAN;tr|Q5T8C6|Q5T8C6_HUMAN","sp|Q13042|CDC16_HUMAN;tr|Q5T8C6|Q5T8C6_HUMAN",2296,"Q13042","CDC16_HUMAN","Cell division cycle protein 16 homolog",null,"CDC16"]
["25.2035","23.748","23.1604","23.3262","23.3716","23.1866",{"$nulls":3},"ribosomal small subunit assembly","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit",{"$nulls":3},13,13,0,"43.7","43.7",0,"32.596",0,"53.354",5788000000,282,"0.537132",1,"0.742486","1.21753","tr|S4R435|S4R435_HUMAN;tr|F6U211|F6U211_HUMAN","tr|S4R435|S4R435_HUMAN;tr|F6U211|F6U211_HUMAN",5627,"S4R435","S4R435_HUMAN",null,null,"RPS10-NUDT3"]
["21.2613","20.4966","21.6496","21.0336","19.5499","20.6022",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;adenylate cyclase-modulating G-protein coupled receptor signaling pathway;cell cycle;cell division;cellular response to forskolin;G-protein coupled receptor signaling pathway;negative regulation of synaptic transmission;positive regulation of protein localization to cell cortex;protein folding;regulation of cAMP-mediated signaling;regulation of mitotic spindle organization;response to peptide hormone","GDP binding;G-protein beta/gamma-subunit complex binding;G-protein coupled receptor binding;G-protein coupled serotonin receptor binding;GTP binding;GTPase activating protein binding;GTPase activity;magnesium ion binding;signal transducer activity","cell cortex region;centrosome;cytoplasm;extracellular exosome;heterotrimeric G-protein complex;lysosomal membrane;membrane raft;midbody;nucleolus;nucleus;plasma membrane","Adrenergic signaling in cardiomyocytes;Alcoholism;Apelin signaling pathway;Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Leukocyte transendothelial migration;Long-term depression;Melanogenesis;Morphine addiction;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Serotonergic synapse;Sphingolipid signaling pathway;Toxoplasmosis",null,null,9,4,4,"29.9",15,15,"40.361",0,"19.603",313310000,24,"0.595993",1,"0.74058","1.33257","sp|P63096|GNAI1_HUMAN;tr|C9JPP4|C9JPP4_HUMAN;tr|C9JL77|C9JL77_HUMAN","sp|P63096|GNAI1_HUMAN;tr|C9JPP4|C9JPP4_HUMAN",2021,"P63096","GNAI1_HUMAN","Guanine nucleotide-binding protein G(i) subunit alpha-1",null,"GNAI1"]
["15.1574","13.4662","14.7569","14.5598","13.1908","13.4083",{"$nulls":3},"protein complex assembly;ribosomal large subunit assembly;rRNA processing","ATP binding;ATPase activity;unfolded protein binding","cytosol;intermediate filament cytoskeleton;membrane;nucleolus;nucleoplasm;nucleus;preribosome, large subunit precursor","Ribosome biogenesis in eukaryotes",null,null,17,17,17,"4.1","4.1","4.1","632.81",0,"31.109",155690000,23,"0.48524",1,"0.740536","1.11542","sp|Q9NU22|MDN1_HUMAN;tr|Q5T795|Q5T795_HUMAN","sp|Q9NU22|MDN1_HUMAN",4727,"Q9NU22","MDN1_HUMAN","Midasin",null,"MDN1"]
["23.9475","22.1957","23.313","22.9075","21.1809","23.1507",{"$nulls":3},"mRNA 3'-end processing;mRNA polyadenylation;mRNA processing;mRNA splicing, via spliceosome;protein tetramerization;termination of RNA polymerase II transcription","AU-rich element binding;histone deacetylase binding;hydrolase activity;identical protein binding;mRNA binding;protein homodimerization activity;RNA binding","centrosome;microtubule organizing center;mRNA cleavage factor complex;nuclear body;nucleoplasm;nucleus;paraspeckles","mRNA surveillance pathway",null,null,9,9,9,"46.7","46.7","46.7","26.227",0,"99.481",1106200000,59,"0.387143",1,"0.73907","0.919064","sp|O43809|CPSF5_HUMAN;tr|H3BND3|H3BND3_HUMAN;tr|H3BV41|H3BV41_HUMAN","sp|O43809|CPSF5_HUMAN;tr|H3BND3|H3BND3_HUMAN;tr|H3BV41|H3BV41_HUMAN",458,"O43809","CPSF5_HUMAN","Cleavage and polyadenylation specificity factor subunit 5",null,"NUDT21"]
["24.1292","22.9495","22.6762","23.6147","21.3537","22.5698",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone",null,"mitochondrial matrix;mitochondrial respiratory chain complex I;mitochondrion",{"$nulls":3},12,12,12,"41.1","41.1","41.1","40.836",0,"153.73",2012400000,107,"0.394591",1,"0.738866","0.93418","tr|A0A087WXC5|A0A087WXC5_HUMAN;sp|O95299|NDUAA_HUMAN;tr|E7ESZ7|E7ESZ7_HUMAN;tr|C9J6X0|C9J6X0_HUMAN;tr|Q8N1B9|Q8N1B9_HUMAN;tr|H7C2W5|H7C2W5_HUMAN;tr|H7C1Y7|H7C1Y7_HUMAN;tr|H7C2X4|H7C2X4_HUMAN","tr|A0A087WXC5|A0A087WXC5_HUMAN;sp|O95299|NDUAA_HUMAN;tr|E7ESZ7|E7ESZ7_HUMAN;tr|C9J6X0|C9J6X0_HUMAN",739,"A0A087WXC5","A0A087WXC5_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|PIRNR:PIRNR000543}",null,"NDUFA10"]
["21.3146","19.9047","21.0205","20.9446","18.424","20.6551",{"$nulls":3},"cellular amino acid metabolic process","identical protein binding;L-serine ammonia-lyase activity;L-threonine ammonia-lyase activity;pyridoxal phosphate binding","extracellular exosome;mitochondrion","Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways;Valine, leucine and isoleucine biosynthesis",null,null,7,7,7,"30.1","30.1","30.1","34.674",0,"50.699",206390000,23,"0.337183",1,"0.738715","0.816473","sp|Q96GA7|SDSL_HUMAN;tr|F8VYZ3|F8VYZ3_HUMAN;tr|H0YID3|H0YID3_HUMAN;tr|F8VZ97|F8VZ97_HUMAN;tr|H0YIA2|H0YIA2_HUMAN","sp|Q96GA7|SDSL_HUMAN;tr|F8VYZ3|F8VYZ3_HUMAN",3890,"Q96GA7","SDSL_HUMAN","Serine dehydratase-like",null,"SDSL"]
["23.6199","21.3159","22.0895","22.695","20.4688","21.6491",{"$nulls":3},"brain development;G1 to G0 transition;kidney development;lung development;negative regulation of epithelial cell proliferation;negative regulation of translation;organonitrogen compound catabolic process;response to lipid;response to salt","deaminase activity;endoribonuclease activity, producing 3'-phosphomonoesters;long-chain fatty acid binding;platinum binding;protein homodimerization activity;RNA binding;transition metal ion binding;xenon atom binding","cytoplasm;cytosol;extracellular exosome;mitochondrial matrix;nucleus;peroxisome",{"$nulls":3},4,4,4,"40.9","40.9","40.9","14.494",0,"106.45",301250000,19,"0.32438",1,"0.737429","0.789803","sp|P52758|UK114_HUMAN;tr|H0YBX3|H0YBX3_HUMAN;tr|H0YB34|H0YB34_HUMAN","sp|P52758|UK114_HUMAN;tr|H0YBX3|H0YBX3_HUMAN;tr|H0YB34|H0YB34_HUMAN",1781,"P52758","RIDA_HUMAN","2-iminobutanoate/2-iminopropanoate deaminase {ECO:0000305|PubMed:22094463}",null,"RIDA"]
["22.1664","20.7146","20.8611","21.1338","19.9004","20.4992",{"$nulls":3},"vesicle-mediated transport",null,"endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus;integral component of membrane;membrane",{"$nulls":3},9,9,9,"33.2","33.2","33.2","43.222",0,"30.982",225250000,11,"0.560383",1,"0.736225","1.26305","sp|Q9Y282|ERGI3_HUMAN;tr|H0Y5K5|H0Y5K5_HUMAN;tr|H0Y621|H0Y621_HUMAN;tr|H0Y802|H0Y802_HUMAN;tr|H0Y6Z0|H0Y6Z0_HUMAN;tr|A6PVJ2|A6PVJ2_HUMAN;tr|A0A0C4DH46|A0A0C4DH46_HUMAN","sp|Q9Y282|ERGI3_HUMAN;tr|H0Y5K5|H0Y5K5_HUMAN;tr|H0Y621|H0Y621_HUMAN",5210,"Q9Y282","ERGI3_HUMAN","Endoplasmic reticulum-Golgi intermediate compartment protein 3",null,"ERGIC3"]
["21.8448","21.1182","21.7446","20.8901","20.0713","21.5414",{"$nulls":3},"actin cytoskeleton reorganization;axis elongation;canonical Wnt signaling pathway;cell adhesion;cell migration;cellular response to retinoic acid;cochlea morphogenesis;convergent extension;coronary vasculature development;establishment of epithelial cell apical/basal polarity;establishment of planar polarity;lung-associated mesenchyme development;planar cell polarity pathway involved in neural tube closure;positive regulation of neuron projection development;signal transduction;ventricular septum development;wound healing","ATP binding;coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway;protein kinase activity","cell-cell junction;focal adhesion;integral component of plasma membrane",{"$nulls":3},37,37,37,"45.5","45.5","45.5","118.39",0,"251.74",2411100000,195,"0.694205",1,"0.734905","1.52391","sp|Q13308|PTK7_HUMAN;tr|H0Y8F1|H0Y8F1_HUMAN;tr|Q86X91|Q86X91_HUMAN;tr|C9JQR6|C9JQR6_HUMAN;tr|H7C5L0|H7C5L0_HUMAN;tr|F8WDG7|F8WDG7_HUMAN;tr|C9J9E8|C9J9E8_HUMAN","sp|Q13308|PTK7_HUMAN",2336,"Q13308","PTK7_HUMAN","Inactive tyrosine-protein kinase 7",null,"PTK7"]
["16.9938",1,"17.121","15.2547",1,"16.6563",{"$nulls":3},"regulation of transcription from RNA polymerase II promoter","translation elongation factor activity","elongin complex",{"$nulls":3},17,17,17,"25.4","25.4","25.4","87.229",0,"90.874",890440000,81,"0.0338816",1,"0.73459","0.100276","tr|A0A024RAC6|A0A024RAC6_HUMAN;sp|Q14241|ELOA1_HUMAN","tr|A0A024RAC6|A0A024RAC6_HUMAN;sp|Q14241|ELOA1_HUMAN",5430,"A0A024RAC6","A0A024RAC6_HUMAN",null,null,"ELOA"]
["17.9813","17.3434","17.0772","16.5206","16.1816","17.4974",{"$nulls":3},"double-strand break repair via nonhomologous end joining;intra-S DNA damage checkpoint","FHA domain binding;protein C-terminus binding","chromosome;focal adhesion;nuclear body;nucleoplasm;nucleus",{"$nulls":3},11,11,11,"12.7","12.7","12.7","226.66",0,"26.475",104800000,28,"0.701972",1,"0.73412","1.53906","sp|Q14676|MDC1_HUMAN;tr|H0Y6Z8|H0Y6Z8_HUMAN","sp|Q14676|MDC1_HUMAN",2489,"Q14676","MDC1_HUMAN","Mediator of DNA damage checkpoint protein 1",null,"MDC1"]
["24.9017","24.0699","23.9009","24.1694","22.7764","23.7243",{"$nulls":3},"protein targeting to ER;proteolysis;signal peptide processing","peptidase activity","endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;organelle membrane;signal peptidase complex","Protein export",null,null,2,2,2,"26.5","26.5","26.5","11.805",0,"7.6158",383180000,19,"0.644783",1,"0.734102","1.42763","sp|Q9Y6A9|SPCS1_HUMAN;tr|C9JBL1|C9JBL1_HUMAN;tr|X6R2S6|X6R2S6_HUMAN","sp|Q9Y6A9|SPCS1_HUMAN;tr|C9JBL1|C9JBL1_HUMAN;tr|X6R2S6|X6R2S6_HUMAN",5399,"Q9Y6A9","SPCS1_HUMAN","Signal peptidase complex subunit 1",null,"SPCS1"]
["26.085","24.8349","25.2394","24.7782","24.161","25.0215",{"$nulls":3},"3'-UTR-mediated mRNA destabilization;cellular response to amino acid stimulus;cellular response to estradiol stimulus;cellular response to nitric oxide;cellular response to putrescine;cerebellum development;circadian regulation of translation;hepatocyte dedifferentiation;liver development;mRNA splicing, via spliceosome;mRNA stabilization;mRNA transcription from RNA polymerase II promoter;positive regulation of gene expression;positive regulation of telomerase RNA reverse transcriptase activity;positive regulation of telomere capping;positive regulation of transcription, DNA-templated;positive regulation of translation;regulation of circadian rhythm;regulation of mRNA stability;regulation of telomere maintenance;regulation of transcription, DNA-templated;response to calcium ion;response to drug;response to electrical stimulus;response to rapamycin;response to sodium phosphate;RNA catabolic process;RNA metabolic process;RNA processing;transcription, DNA-templated","AT DNA binding;chromatin binding;histone deacetylase binding;mRNA 3'-UTR AU-rich region binding;RNA binding;telomeric DNA binding;transcription factor binding","cytosol;extracellular exosome;intracellular ribonucleoprotein complex;nucleoplasm;nucleus",{"$nulls":3},13,13,12,"36.6","36.6","34.4","38.434",0,"219.36",4500200000,119,"0.750476",1,"0.732886","1.63383","sp|Q14103|HNRPD_HUMAN;tr|H0Y8G5|H0Y8G5_HUMAN;tr|H0YA96|H0YA96_HUMAN;tr|D6RAF8|D6RAF8_HUMAN;tr|D6RD83|D6RD83_HUMAN;tr|D6RF44|D6RF44_HUMAN;tr|D6RBQ9|D6RBQ9_HUMAN","sp|Q14103|HNRPD_HUMAN;tr|H0Y8G5|H0Y8G5_HUMAN;tr|H0YA96|H0YA96_HUMAN;tr|D6RAF8|D6RAF8_HUMAN",2430,"Q14103","HNRPD_HUMAN","Heterogeneous nuclear ribonucleoprotein D0","nRNP D0","HNRNPD"]
["22.8039","21.3212","21.2613","21.5529","20.8541","20.7874",{"$nulls":3},"cytoplasmic mRNA processing body assembly;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process;RNA splicing;spliceosomal complex assembly;spliceosomal snRNP assembly","PH domain binding;RNA binding;U6 snRNA binding","cytosol;membrane;neuron projection;nucleoplasm;P-body;protein complex;spliceosomal complex;spliceosomal tri-snRNP complex;U6 snRNP","RNA degradation;Spliceosome",null,null,4,4,4,"26.6","26.6","26.6","15.35",0,"9.2124",284290000,24,"0.580855",1,"0.730706","1.30304","sp|Q9Y4Z0|LSM4_HUMAN;tr|V9GZ56|V9GZ56_HUMAN;tr|U3KQS7|U3KQS7_HUMAN;tr|M0QXB0|M0QXB0_HUMAN;tr|U3KQK1|U3KQK1_HUMAN","sp|Q9Y4Z0|LSM4_HUMAN;tr|V9GZ56|V9GZ56_HUMAN;tr|U3KQS7|U3KQS7_HUMAN;tr|M0QXB0|M0QXB0_HUMAN;tr|U3KQK1|U3KQK1_HUMAN",5338,"Q9Y4Z0","LSM4_HUMAN","U6 snRNA-associated Sm-like protein LSm4",null,"LSM4"]
["22.235","20.709","20.6822","20.4246","20.0893","20.9207",{"$nulls":3},"protein folding in endoplasmic reticulum",null,"cytoplasm;endoplasmic reticulum;ER membrane protein complex;mitochondrion;nucleus",{"$nulls":3},7,7,7,"32.7","32.7","32.7","34.833",0,"19.638",305140000,17,"0.573165",1,"0.730552","1.28802","sp|Q15006|EMC2_HUMAN;tr|H0YAS9|H0YAS9_HUMAN;tr|E5RGJ2|E5RGJ2_HUMAN","sp|Q15006|EMC2_HUMAN",2532,"Q15006","EMC2_HUMAN","ER membrane protein complex subunit 2",null,"EMC2"]
["21.8785","20.4412","20.1704","20.748","18.7528","20.799",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,7,7,7,38,38,38,"24.915",0,"20.318",263820000,20,"0.3542",1,"0.730084","0.851667","sp|Q96A35|RM24_HUMAN;tr|X6RJ73|X6RJ73_HUMAN;tr|X6RHI2|X6RHI2_HUMAN;tr|X6RIR5|X6RIR5_HUMAN","sp|Q96A35|RM24_HUMAN",3779,"Q96A35","RM24_HUMAN","39S ribosomal protein L24, mitochondrial","24mt;RP-L24","MRPL24"]
["18.2809","17.244","18.3211","17.4494","16.8012","17.4079",{"$nulls":3},"mRNA 3'-end processing;mRNA cleavage;mRNA export from nucleus;mRNA polyadenylation;mRNA splicing, via spliceosome;pre-mRNA cleavage required for polyadenylation;termination of RNA polymerase II transcription;tRNA splicing, via endonucleolytic cleavage and ligation","enzyme binding;mRNA 3'-UTR AU-rich region binding","mRNA cleavage and polyadenylation specificity factor complex;nucleoplasm","mRNA surveillance pathway",null,null,12,12,12,"10.7","10.7","10.7","160.88",0,"43.643",276880000,30,"0.823962",1,"0.729219","1.7783","sp|Q10570|CPSF1_HUMAN;tr|A0A087X101|A0A087X101_HUMAN;tr|E9PIM1|E9PIM1_HUMAN","sp|Q10570|CPSF1_HUMAN",2253,"Q10570","CPSF1_HUMAN","Cleavage and polyadenylation specificity factor subunit 1",null,"CPSF1"]
["23.4238","21.2433","23.3005","22.8089","20.6608","22.3106",{"$nulls":3},"mRNA splicing, via spliceosome;RNA metabolic process","RNA binding","catalytic step 2 spliceosome;intracellular ribonucleoprotein complex;nucleoplasm;nucleus","Spliceosome",null,null,11,11,11,"35.7","35.7","35.7","39.594",0,"101.54",1168400000,77,"0.309968",1,"0.729132","0.759568","sp|P51991|ROA3_HUMAN;tr|H7C1J8|H7C1J8_HUMAN","sp|P51991|ROA3_HUMAN",1763,"P51991","ROA3_HUMAN","Heterogeneous nuclear ribonucleoprotein A3","nRNP A3","HNRNPA3"]
["26.0315","24.3913","25.2325","25.1437","23.4532","24.8789",{"$nulls":3},"embryonic forelimb morphogenesis;epidermis development;positive regulation of collateral sprouting;regulation of retinoic acid receptor signaling pathway;regulation of transcription, DNA-templated;retinoic acid metabolic process;signal transduction","retinal binding;retinoic acid binding;retinoid binding;retinol binding","cytosol;endoplasmic reticulum;extracellular exosome;nucleoplasm",{"$nulls":3},10,10,10,"63.8","63.8","63.8","15.693",0,"145.92",3301300000,88,"0.441027",1,"0.72646","1.02759","sp|P29373|RABP2_HUMAN;tr|Q5SYZ4|Q5SYZ4_HUMAN;tr|B5MCB5|B5MCB5_HUMAN;sp|P29762|RABP1_HUMAN","sp|P29373|RABP2_HUMAN;tr|Q5SYZ4|Q5SYZ4_HUMAN",1358,"P29373","RABP2_HUMAN","Cellular retinoic acid-binding protein 2",null,"CRABP2"]
["18.9045","16.3981","18.0509","18.6536","15.0046","17.518",{"$nulls":3},"G-protein coupled receptor signaling pathway;intracellular signal transduction;positive regulation of apoptotic process;regulation of Rho protein signal transduction;regulation of small GTPase mediated signal transduction","G-protein coupled receptor binding;GTPase activator activity;guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity","cytoplasm;cytosol;extracellular exosome;membrane","Axon guidance;C-type lectin receptor signaling pathway;Human cytomegalovirus infection;Pathways in cancer;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Tuberculosis;Vascular smooth muscle contraction;Yersinia infection",null,null,13,13,13,"14.6","14.6","14.6","173.23",0,"38.497",181160000,40,"0.216235",1,"0.725773","0.55606","sp|Q9NZN5|ARHGC_HUMAN;tr|E9PMR6|E9PMR6_HUMAN","sp|Q9NZN5|ARHGC_HUMAN;tr|E9PMR6|E9PMR6_HUMAN",4886,"Q9NZN5","ARHGC_HUMAN","Rho guanine nucleotide exchange factor 12",null,"ARHGEF12"]
["20.2423","18.0674","19.6642","18.7013","17.1782","19.9252",{"$nulls":3},"face morphogenesis;leukocyte differentiation;negative regulation of cell migration;positive regulation of angiogenesis;Ras protein signal transduction;regulation of ERK1 and ERK2 cascade;regulation of protein kinase B signaling","GDP binding;GTP binding;GTPase activity;protein complex binding","extracellular exosome;focal adhesion;intracellular;plasma membrane","Apelin signaling pathway;Autophagy - animal;Axon guidance;cAMP signaling pathway;Cellular senescence;C-type lectin receptor signaling pathway;MAPK signaling pathway;Mitophagy - animal;Phospholipase D signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton",null,null,5,3,3,33,"20.6","20.6","23.48",0,"20.21",69849000,7,"0.283856",1,"0.723035","0.704156","sp|P10301|RRAS_HUMAN","sp|P10301|RRAS_HUMAN",1016,"P10301","RRAS_HUMAN","Ras-related protein R-Ras",null,"RRAS"]
["20.2007","18.7917","20.9471","19.3572","18.392","20.022",{"$nulls":3},"fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA dehydrogenase","acyl-CoA dehydrogenase activity;butyryl-CoA dehydrogenase activity;flavin adenine dinucleotide binding","mitochondrial matrix;mitochondrion;nucleoplasm;nucleus","beta-Alanine metabolism;Butanoate metabolism;Carbon metabolism;Fatty acid degradation;Fatty acid metabolism;Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,8,8,8,"27.7","27.7","27.7","44.297",0,"24.079",181690000,26,"0.385403",1,"0.722764","0.915525","sp|P16219|ACADS_HUMAN;tr|E9PE82|E9PE82_HUMAN","sp|P16219|ACADS_HUMAN;tr|E9PE82|E9PE82_HUMAN",1131,"P16219","ACADS_HUMAN","Short-chain specific acyl-CoA dehydrogenase, mitochondrial","CAD","ACADS"]
["22.0771","20.7104","21.4708","21.0754","20.0226","20.9922",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;cellular response to glucagon stimulus;intracellular signal transduction;negative regulation of cAMP-dependent protein kinase activity;renal water homeostasis","cAMP binding;cAMP-dependent protein kinase inhibitor activity;cAMP-dependent protein kinase regulator activity;protein domain specific binding;protein kinase A catalytic subunit binding;ubiquitin protein ligase binding","cAMP-dependent protein kinase complex;centrosome;ciliary base;cytoplasm;cytosol;extracellular exosome;focal adhesion;membrane;nucleotide-activated protein kinase complex;plasma membrane;plasma membrane raft;protein complex","Insulin signaling pathway",null,null,12,12,10,"42.1","42.1","35.4","45.518",0,"93.868",510460000,45,"0.625209",1,"0.7227","1.3895","sp|P13861|KAP2_HUMAN;tr|H7C330|H7C330_HUMAN;tr|C9J830|C9J830_HUMAN;tr|H7C1L0|H7C1L0_HUMAN","sp|P13861|KAP2_HUMAN",1093,"P13861","KAP2_HUMAN","cAMP-dependent protein kinase type II-alpha regulatory subunit",null,"PRKAR2A"]
["23.4885","21.3709","22.0191","22.6934","20.4943","21.5227",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"35.8","35.8","35.8","17.963",0,"157.81",226750000,22,"0.334085",1,"0.722693","0.810035","tr|E9PJK1|E9PJK1_HUMAN;tr|E9PRJ8|E9PRJ8_HUMAN;tr|H0YDL9|H0YDL9_HUMAN;tr|H0YDJ9|H0YDJ9_HUMAN;sp|P60033|CD81_HUMAN;tr|E9PIF1|E9PIF1_HUMAN;tr|A6NMH8|A6NMH8_HUMAN;tr|E9PM31|E9PM31_HUMAN;tr|H0YEE2|H0YEE2_HUMAN","tr|E9PJK1|E9PJK1_HUMAN;tr|E9PRJ8|E9PRJ8_HUMAN;tr|H0YDL9|H0YDL9_HUMAN;tr|H0YDJ9|H0YDJ9_HUMAN;sp|P60033|CD81_HUMAN;tr|E9PIF1|E9PIF1_HUMAN;tr|A6NMH8|A6NMH8_HUMAN",1887,"E9PJK1","E9PJK1_HUMAN","Tetraspanin {ECO:0000256|RuleBase:RU361218}",null,"CD81"]
["24.3257","23.2693","23.2929","23.6574","21.7872","23.2757",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;response to oxidative stress","NADH dehydrogenase (ubiquinone) activity","extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion;nuclear membrane","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,7,7,7,"42.6","42.6","42.6","15.208",0,"33.558",849460000,63,"0.467836",1,"0.722543","1.08095","sp|O95168|NDUB4_HUMAN;tr|F2Z3P9|F2Z3P9_HUMAN;tr|C9JXQ9|C9JXQ9_HUMAN","sp|O95168|NDUB4_HUMAN;tr|F2Z3P9|F2Z3P9_HUMAN;tr|C9JXQ9|C9JXQ9_HUMAN",717,"O95168","NDUB4_HUMAN","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4",null,"NDUFB4"]
["18.5047","17.8685","18.1527","17.4569","17.16","17.7413",{"$nulls":3},"cell adhesion;cell migration;negative regulation of receptor binding;neuron projection regeneration;peptidyl-tyrosine dephosphorylation;regulation of axon regeneration;transmembrane receptor protein tyrosine phosphatase signaling pathway","chondroitin sulfate proteoglycan binding;heparin binding;protein complex binding;protein tyrosine phosphatase activity;transmembrane receptor protein tyrosine phosphatase activity","extracellular exosome;integral component of plasma membrane;neuron projection;neuronal cell body;plasma membrane","Adherens junction;Cell adhesion molecules (CAMs);Insulin resistance;Insulin signaling pathway",null,null,28,28,23,"21.9","21.9","18.7","212.88",0,"73.31",326490000,59,"1.35607",1,"0.722541","2.90156","sp|P10586|PTPRF_HUMAN;tr|H0Y6Z7|H0Y6Z7_HUMAN;tr|H0Y4H1|H0Y4H1_HUMAN;tr|H0Y7Z9|H0Y7Z9_HUMAN;tr|H0Y380|H0Y380_HUMAN;tr|A2A437|A2A437_HUMAN","sp|P10586|PTPRF_HUMAN;tr|H0Y6Z7|H0Y6Z7_HUMAN;tr|H0Y4H1|H0Y4H1_HUMAN;tr|H0Y7Z9|H0Y7Z9_HUMAN",1019,"P10586","PTPRF_HUMAN","Receptor-type tyrosine-protein phosphatase F",null,"PTPRF"]
["17.3874","16.4695","17.8848","15.9583","16.1321","17.4853",{"$nulls":4},"SUMO transferase activity;zinc ion binding",{"$nulls":4},2,2,2,"4.9","4.9","4.9","59.642",0,"6.8197",52742000,7,"0.49507",1,"0.721996","1.13483","tr|A0A087WUY7|A0A087WUY7_HUMAN;sp|O75928|PIAS2_HUMAN;tr|B4DGW0|B4DGW0_HUMAN;sp|O75925|PIAS1_HUMAN","tr|A0A087WUY7|A0A087WUY7_HUMAN;sp|O75928|PIAS2_HUMAN;tr|B4DGW0|B4DGW0_HUMAN;sp|O75925|PIAS1_HUMAN",650,"A0A087WUY7","A0A087WUY7_HUMAN",null,null,"PIAS2"]
["25.6231","23.79","23.304","24.4121","23.2419","22.8972",{"$nulls":3},"chaperone-mediated protein folding","FK506 binding;peptidyl-prolyl cis-trans isomerase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome",{"$nulls":3},4,4,4,"48.6","48.6","48.6","15.649",0,"112.03",1306100000,28,"0.357068",1,"0.721985","0.857572","sp|P26885|FKBP2_HUMAN;tr|F5H0N4|F5H0N4_HUMAN","sp|P26885|FKBP2_HUMAN;tr|F5H0N4|F5H0N4_HUMAN",1314,"P26885","FKBP2_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP2","PIase FKBP2","FKBP2"]
["22.6909","21.6577","22.9088","21.1705","20.9251","22.9971",{"$nulls":3},"positive regulation of apoptotic process;protein localization to mitochondrion",null,"extracellular exosome;integral component of membrane;membrane;mitochondrial inner membrane;mitochondrion;nucleus",{"$nulls":3},9,9,2,"43.9","43.9","9.2","33.331",0,"120.23",1024900000,103,"0.40276",1,"0.72159","0.950713","sp|Q9Y6C9|MTCH2_HUMAN","sp|Q9Y6C9|MTCH2_HUMAN",5401,"Q9Y6C9","MTCH2_HUMAN","Mitochondrial carrier homolog 2",null,"MTCH2"]
["24.17","23.8794","23.7641","23.3444","22.9837","23.3253",{"$nulls":3},"2-oxoglutarate metabolic process;aging;branched-chain amino acid catabolic process;cell redox homeostasis;cellular nitrogen compound metabolic process;dihydrolipoamide metabolic process;gastrulation;lipoate metabolic process;lysine catabolic process;mitochondrial acetyl-CoA biosynthetic process from pyruvate;mitochondrial electron transport, NADH to ubiquinone;proteolysis;pyruvate metabolic process;regulation of acetyl-CoA biosynthetic process from pyruvate;regulation of membrane potential;sperm capacitation;tricarboxylic acid cycle","dihydrolipoyl dehydrogenase activity;electron transfer activity;flavin adenine dinucleotide binding;lipoamide binding;NAD binding","acrosomal matrix;mitochondrial matrix;mitochondrion;motile cilium;myelin sheath;nucleoplasm;oxoglutarate dehydrogenase complex;pyruvate dehydrogenase complex","Carbon metabolism;Citrate cycle (TCA cycle);Glycine, serine and threonine metabolism;Glycolysis / Gluconeogenesis;Glyoxylate and dicarboxylate metabolism;Lysine degradation;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,14,14,14,"43.4","43.4","43.4","54.177",0,"173.51",3069100000,121,"1.89095",1,"0.72005","4.27935","sp|P09622|DLDH_HUMAN;tr|E9PEX6|E9PEX6_HUMAN;tr|F8WDM5|F8WDM5_HUMAN;tr|F2Z2E3|F2Z2E3_HUMAN","sp|P09622|DLDH_HUMAN;tr|E9PEX6|E9PEX6_HUMAN",995,"P09622","DLDH_HUMAN","Dihydrolipoyl dehydrogenase, mitochondrial",null,"DLD"]
["18.3483",1,"18.4471","17.683",1,"16.9565",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;apoptotic process;cell surface receptor signaling pathway;cellular response to mechanical stimulus;cellular response to oxidised low-density lipoprotein particle stimulus;defense response to Gram-positive bacterium;inflammatory response;MyD88-dependent toll-like receptor signaling pathway;negative regulation of apoptotic process;positive regulation of cytokine production involved in inflammatory response;positive regulation of gene expression;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interleukin-17 production;positive regulation of interleukin-23 production;positive regulation of interleukin-6 production;positive regulation of NF-kappaB transcription factor activity;positive regulation of type I interferon production;regulation of inflammatory response;response to interleukin-1;signal transduction;toll-like receptor 9 signaling pathway;toll-like receptor signaling pathway;type I interferon signaling pathway","death receptor binding;identical protein binding;protein self-association;TIR domain binding","cytoplasm;cytosol;endosome membrane;nucleus;plasma membrane","African trypanosomiasis;Chagas disease (American trypanosomiasis);Epstein-Barr virus infection;Hepatitis B;Herpes simplex virus 1 infection;Human immunodeficiency virus 1 infection;Influenza A;Legionellosis;Leishmaniasis;Malaria;MAPK signaling pathway;Measles;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Pertussis;Salmonella infection;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;Yersinia infection",null,null,2,2,2,"8.1","8.1","8.1","33.233","0.00041632","4.2925",42949000,5,"0.030418",1,"0.718615","0.0903446","sp|Q99836|MYD88_HUMAN;tr|A0A0A0MS70|A0A0A0MS70_HUMAN;tr|H0Y4G9|H0Y4G9_HUMAN;tr|A0A0A0MST0|A0A0A0MST0_HUMAN;tr|A0A0A0MSI9|A0A0A0MSI9_HUMAN","sp|Q99836|MYD88_HUMAN;tr|A0A0A0MS70|A0A0A0MS70_HUMAN;tr|H0Y4G9|H0Y4G9_HUMAN;tr|A0A0A0MST0|A0A0A0MST0_HUMAN;tr|A0A0A0MSI9|A0A0A0MSI9_HUMAN",4115,"Q99836","MYD88_HUMAN","Myeloid differentiation primary response protein MyD88",null,"MYD88"]
["20.4271","19.0243","19.5396","20.7762","17.4501","18.6102",{"$nulls":4},"aminoacyl-tRNA hydrolase activity",{"$nulls":4},5,5,5,"32.6","32.6","32.6","18.43",0,"38.775",283150000,20,"0.272247",1,"0.718149","0.679236","tr|A0A096LP22|A0A096LP22_HUMAN;sp|Q86Y79|PTH_HUMAN;tr|C9J7Z1|C9J7Z1_HUMAN;tr|A0A096LP34|A0A096LP34_HUMAN;tr|A0A096LPA3|A0A096LPA3_HUMAN","tr|A0A096LP22|A0A096LP22_HUMAN;sp|Q86Y79|PTH_HUMAN;tr|C9J7Z1|C9J7Z1_HUMAN;tr|A0A096LP34|A0A096LP34_HUMAN;tr|A0A096LPA3|A0A096LPA3_HUMAN",3265,"A0A096LP22","A0A096LP22_HUMAN",null,null,"PTRH1"]
["25.4814","23.8391","24.4573","24.5281","23.1006","23.9951",{"$nulls":3},"fatty acid beta-oxidation using acyl-CoA dehydrogenase;respiratory electron transport chain","electron transfer activity;flavin adenine dinucleotide binding;oxidoreductase activity","extracellular exosome;mitochondrial matrix;mitochondrion",{"$nulls":3},15,15,15,"65.2","65.2","65.2","35.079",0,"197.68",4236500000,142,"0.493304",1,"0.717997","1.13135","sp|P13804|ETFA_HUMAN;tr|H0YLU7|H0YLU7_HUMAN;tr|H0YK49|H0YK49_HUMAN;tr|H0YL12|H0YL12_HUMAN;tr|H0YNX6|H0YNX6_HUMAN;tr|H0YKF0|H0YKF0_HUMAN;tr|H0YL83|H0YL83_HUMAN;tr|J3KN60|J3KN60_HUMAN;tr|H0YM12|H0YM12_HUMAN","sp|P13804|ETFA_HUMAN;tr|H0YLU7|H0YLU7_HUMAN;tr|H0YK49|H0YK49_HUMAN;tr|H0YL12|H0YL12_HUMAN;tr|H0YNX6|H0YNX6_HUMAN;tr|H0YKF0|H0YKF0_HUMAN",1091,"P13804","ETFA_HUMAN","Electron transfer flavoprotein subunit alpha, mitochondrial","lpha-ETF","ETFA"]
["22.3691","19.9413","21.0362","21.3078","19.3889","20.4966",{"$nulls":3},"copper ion homeostasis;copper ion transport;protein tetramerization","copper ion binding","cytoplasm;cytosol;nucleolus;nucleoplasm;nucleus",{"$nulls":3},7,7,7,"43.6","43.6","43.6","29.341",0,"38.37",246550000,22,"0.329989",1,"0.717799","0.801508","sp|Q9NTM9|CUTC_HUMAN;tr|Q5TCZ7|Q5TCZ7_HUMAN;tr|A0A0B4J226|A0A0B4J226_HUMAN","sp|Q9NTM9|CUTC_HUMAN;tr|Q5TCZ7|Q5TCZ7_HUMAN;tr|A0A0B4J226|A0A0B4J226_HUMAN",4723,"Q9NTM9","CUTC_HUMAN","Copper homeostasis protein cutC homolog",null,"CUTC"]
["23.671","22.914","21.0857","22.5899","21.3107","21.6175",{"$nulls":3},"macroautophagy;positive regulation of mitophagy in response to mitochondrial depolarization;positive regulation of protein targeting to mitochondrion;protein import into mitochondrial matrix;protein import into mitochondrial outer membrane;protein targeting to mitochondrion;regulation of protein stability","protein transmembrane transporter activity","integral component of mitochondrial outer membrane;mitochondrial outer membrane;mitochondrial outer membrane translocase complex;mitochondrion","Mitophagy - animal",null,null,3,3,3,"45.5","45.5","45.5","6.2484",0,"11.601",602550000,43,"0.346383",1,"0.717551","0.835534","sp|Q9P0U1|TOM7_HUMAN;tr|B5MD00|B5MD00_HUMAN;tr|A0A087WZY2|A0A087WZY2_HUMAN;tr|A6NIV2|A6NIV2_HUMAN","sp|Q9P0U1|TOM7_HUMAN;tr|B5MD00|B5MD00_HUMAN",4913,"Q9P0U1","TOM7_HUMAN","Mitochondrial import receptor subunit TOM7 homolog",null,"TOMM7"]
["24.7216","24.1216","24.3721","23.8842","23.1552","24.0242",{"$nulls":3},"defense response to virus;negative regulation of transcription, DNA-templated;negative regulation of translation;negative regulation of viral genome replication;positive regulation of transcription, DNA-templated;protein phosphorylation;transcription, DNA-templated","DNA binding;double-stranded RNA binding;RNA binding","cytoplasm;extracellular region;intracellular ribonucleoprotein complex;membrane;mitochondrion;nucleolus;nucleoplasm;nucleus",{"$nulls":3},37,37,33,"57.8","57.8",54,"95.337",0,"323.31",5789800000,250,"1.05075",1,"0.717198","2.23644","sp|Q12906|ILF3_HUMAN;tr|K7EKJ9|K7EKJ9_HUMAN;tr|K7EQR9|K7EQR9_HUMAN;tr|K7ER69|K7ER69_HUMAN;tr|K7EKY0|K7EKY0_HUMAN;tr|K7ERM6|K7ERM6_HUMAN;tr|K7ENK6|K7ENK6_HUMAN;tr|K7EM82|K7EM82_HUMAN;tr|K7EJ09|K7EJ09_HUMAN;tr|K7EPG3|K7EPG3_HUMAN;tr|K7ELV3|K7ELV3_HUMAN;tr|K7EQ75|K7EQ75_HUMAN","sp|Q12906|ILF3_HUMAN",2279,"Q12906","ILF3_HUMAN","Interleukin enhancer-binding factor 3",null,"ILF3"]
["22.513","19.5071","20.9027","21.707","19.1468","19.9184",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intra-Golgi vesicle-mediated transport;protein transport;retrograde vesicle-mediated transport, Golgi to ER","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;nucleoplasm;transport vesicle",{"$nulls":3},8,8,8,"46.8","46.8","46.8","34.482",0,"71.006",266200000,28,"0.245834",1,"0.716867","0.621796","sp|O14579|COPE_HUMAN;tr|M0QXB4|M0QXB4_HUMAN;tr|A0A087X0I4|A0A087X0I4_HUMAN;tr|M0R061|M0R061_HUMAN","sp|O14579|COPE_HUMAN;tr|M0QXB4|M0QXB4_HUMAN;tr|A0A087X0I4|A0A087X0I4_HUMAN",273,"O14579","COPE_HUMAN","Coatomer subunit epsilon",null,"COPE"]
["19.5332","18.5323","19.3905","18.9975","18.3814","17.9295",{"$nulls":5},"extracellular space;Golgi apparatus;microtubule;microtubule cytoskeleton;microtubule organizing center;mitochondrion;nucleolus;plasma membrane;spindle",{"$nulls":3},17,17,17,"18.4","18.4","18.4","141.4",0,"77.257",538390000,61,"0.747198",1,"0.715846","1.62741","sp|Q9ULD2|MTUS1_HUMAN;tr|H0YC63|H0YC63_HUMAN","sp|Q9ULD2|MTUS1_HUMAN",5116,"Q9ULD2","MTUS1_HUMAN","Microtubule-associated tumor suppressor 1",null,"MTUS1"]
["26.6874","25.77","26.4458","25.9059","25.1351","25.7211",{"$nulls":3},"animal organ regeneration;defense response to bacterium;hippocampus development;neutrophil degranulation;phagocytosis;positive regulation of angiogenesis;positive regulation of DNA binding transcription factor activity;positive regulation of DNA metabolic process;positive regulation of endothelial cell migration;response to glucocorticoid;response to growth factor","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;phospholipase A2 inhibitor activity","axon;cytoplasm;cytosol;dendrite;extracellular exosome;membrane;neuronal cell body;phagocytic vesicle membrane;plasma membrane;specific granule",{"$nulls":3},23,23,23,"64.1","64.1","64.1","36.375",0,"323.31",14839000000,266,"0.927319",1,"0.713689","1.98431","sp|P12429|ANXA3_HUMAN;tr|D6RA82|D6RA82_HUMAN;tr|D6RFG5|D6RFG5_HUMAN;tr|D6RCA8|D6RCA8_HUMAN;tr|D6RAZ8|D6RAZ8_HUMAN;tr|D6RFJ9|D6RFJ9_HUMAN","sp|P12429|ANXA3_HUMAN;tr|D6RA82|D6RA82_HUMAN",1066,"P12429","ANXA3_HUMAN","Annexin A3",null,"ANXA3"]
["23.2968","21.4083","20.9506","21.7615","21.1416","20.6165",{"$nulls":3},"NAD biosynthesis via nicotinamide riboside salvage pathway;NADH metabolic process;NADP metabolic process;nicotinamide nucleotide metabolic process;protein homotetramerization","metal ion binding;NADHX epimerase activity;NADPHX epimerase activity;nucleotide binding;protein homodimerization activity","cell body;cilium;cytosol;extracellular exosome;extracellular region;extracellular space;intracellular membrane-bounded organelle;mitochondrial matrix;mitochondrion;nucleoplasm",{"$nulls":3},6,6,6,"26.4","26.4","26.4","31.674",0,"37.246",440500000,33,"0.378057",1,"0.712034","0.900565","sp|Q8NCW5|NNRE_HUMAN;tr|Q5T3I4|Q5T3I4_HUMAN;tr|Q5T3I3|Q5T3I3_HUMAN","sp|Q8NCW5|NNRE_HUMAN;tr|Q5T3I4|Q5T3I4_HUMAN",3475,"Q8NCW5","NNRE_HUMAN","NAD(P)H-hydrate epimerase {ECO:0000255|HAMAP-Rule:MF_03159}",null,"NAXE"]
["18.4326","18.0554","18.4199","17.1394","17.336","18.2968",{"$nulls":3},"axonogenesis;brain morphogenesis;cell-cell adhesion;dendrite morphogenesis;positive regulation of muscle cell differentiation;prepulse inhibition;radial glia guided migration of Purkinje cell;regulation of synapse structural plasticity","actin filament binding;cadherin binding;identical protein binding;structural constituent of cytoskeleton","actin cytoskeleton;adherens junction;axon;basolateral plasma membrane;cell-cell adherens junction;cytoplasm;cytosol;lamellipodium;nucleus;postsynaptic density","Adherens junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Endometrial cancer;Gastric cancer;Hippo signaling pathway;Leukocyte transendothelial migration;Pathways in cancer",null,null,11,2,2,"13.5","3.8","3.8","105.31",0,"25.496",233950000,24,"0.875959",1,"0.711859","1.88145","sp|P26232|CTNA2_HUMAN;tr|C9IZ88|C9IZ88_HUMAN;tr|C9J144|C9J144_HUMAN","sp|P26232|CTNA2_HUMAN",1303,"P26232","CTNA2_HUMAN","Catenin alpha-2",null,"CTNNA2"]
["19.5763","18.4985","17.9503","18.2738","17.7801","17.8379",{"$nulls":3},"membrane biogenesis;phosphatidylserine metabolic process;phospholipid biosynthetic process;positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity;positive regulation of serine C-palmitoyltransferase activity;sphingolipid metabolic process","enzyme binding;L-serine transmembrane transporter activity;protein binding, bridging","endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;plasma membrane",{"$nulls":3},2,2,2,"6.6","6.6","6.6","50.494",0,"7.2448",50682000,5,"0.638444",1,"0.711053","1.41528","sp|Q9NRX5|SERC1_HUMAN","sp|Q9NRX5|SERC1_HUMAN",4704,"Q9NRX5","SERC1_HUMAN","Serine incorporator 1",null,"SERINC1"]
["17.9006","16.2705","16.537","16.7108","16.3342","15.5341",{"$nulls":5},"cytosol;intracellular membrane-bounded organelle",{"$nulls":3},6,6,6,"6.5","6.5","6.5","148.82",0,"13.703",73088000,13,"0.507093",1,"0.709669","1.15853","tr|C9JKF1|C9JKF1_HUMAN;sp|Q5K651|SAMD9_HUMAN","tr|C9JKF1|C9JKF1_HUMAN;sp|Q5K651|SAMD9_HUMAN",2836,"C9JKF1","C9JKF1_HUMAN",null,null,"SAMD9"]
["24.7095","22.6913","22.9608","23.5861","22.04","22.6075",{"$nulls":3},"ATP biosynthetic process;ATP hydrolysis coupled cation transmembrane transport;ATP synthesis coupled proton transport;cristae formation;mitochondrial ATP synthesis coupled proton transport","hydrogen ion transmembrane transporter activity;transmembrane transporter activity","cytosol;extracellular exosome;mitochondrial inner membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase, stator stalk;mitochondrion;myelin sheath;nucleoplasm","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,8,8,8,59,59,59,"18.491",0,"40.03",955320000,35,"0.383969",1,"0.709339","0.912608","sp|O75947|ATP5H_HUMAN;tr|F5H608|F5H608_HUMAN","sp|O75947|ATP5H_HUMAN;tr|F5H608|F5H608_HUMAN",656,"O75947","ATP5H_HUMAN","ATP synthase subunit d, mitochondrial","TPase subunit d","ATP5H"]
["26.1213","23.4775","25.474","25.3241","22.697","24.9255",{"$nulls":4},"DNA binding","nucleus",{"$nulls":3},5,5,5,34,34,34,"17.522",0,"47.685",1698000000,50,"0.245624",1,"0.708741","0.621336","tr|E9PES6|E9PES6_HUMAN;tr|E7ES08|E7ES08_HUMAN;tr|E7EQU1|E7EQU1_HUMAN;sp|O15347|HMGB3_HUMAN","tr|E9PES6|E9PES6_HUMAN;tr|E7ES08|E7ES08_HUMAN;tr|E7EQU1|E7EQU1_HUMAN;sp|O15347|HMGB3_HUMAN",365,"E9PES6","E9PES6_HUMAN",null,null,"HMGB3"]
["24.7309","23.2771","23.742","23.9788","22.1748","23.4702",{"$nulls":3},"actin filament organization;adherens junction organization;aging;apical junction assembly;axon regeneration;cell adhesion;cellular protein localization;cellular response to indole-3-methanol;epithelial cell-cell adhesion;establishment or maintenance of cell polarity;gap junction assembly;male gonad development;negative regulation of cell motility;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;negative regulation of integrin-mediated signaling pathway;negative regulation of neuroblast proliferation;odontogenesis of dentin-containing tooth;ovarian follicle development;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;positive regulation of muscle cell differentiation;positive regulation of smoothened signaling pathway;protein heterooligomerization;response to estrogen","actin filament binding;beta-catenin binding;cadherin binding;gamma-catenin binding;identical protein binding;protein heterodimerization activity;RNA binding;structural molecule activity;vinculin binding","acrosomal vesicle;actin cytoskeleton;catenin complex;cell junction;cell-cell junction;cytosol;flotillin complex;focal adhesion;Golgi apparatus;intercalated disc;intracellular membrane-bounded organelle;lamellipodium;plasma membrane;zonula adherens","Adherens junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Endometrial cancer;Gastric cancer;Hippo signaling pathway;Leukocyte transendothelial migration;Pathways in cancer",null,null,43,43,34,"66.3","66.3","57.5","100.07",0,"323.31",7061900000,304,"0.442967",1,"0.708735","1.03146","sp|P35221|CTNA1_HUMAN;tr|G3XAM7|G3XAM7_HUMAN;tr|E5RIB1|E5RIB1_HUMAN;tr|E5RG03|E5RG03_HUMAN;tr|E5RGY6|E5RGY6_HUMAN;tr|E5RHV7|E5RHV7_HUMAN;tr|E5RJ41|E5RJ41_HUMAN;tr|E5RJL0|E5RJL0_HUMAN;tr|E5RIE0|E5RIE0_HUMAN;tr|E5RJP7|E5RJP7_HUMAN;tr|E5RGD2|E5RGD2_HUMAN;tr|E5RFK9|E5RFK9_HUMAN;tr|E5RFM5|E5RFM5_HUMAN;tr|H0YBB8|H0YBB8_HUMAN;tr|E5RGY7|E5RGY7_HUMAN;tr|A0A0A0MRI5|A0A0A0MRI5_HUMAN;tr|E5RFG3|E5RFG3_HUMAN;tr|E5RFM3|E5RFM3_HUMAN;tr|A0A0A0MTJ6|A0A0A0MTJ6_HUMAN;tr|A0A087WZL6|A0A087WZL6_HUMAN;tr|E5RGU3|E5RGU3_HUMAN;tr|E5RHJ5|E5RHJ5_HUMAN;tr|E5RJZ2|E5RJZ2_HUMAN;tr|E5RGG4|E5RGG4_HUMAN;tr|E5RJ43|E5RJ43_HUMAN;tr|E5RGS1|E5RGS1_HUMAN;tr|E5RIT8|E5RIT8_HUMAN;tr|B9A010|B9A010_HUMAN;sp|Q9UI47|CTNA3_HUMAN","sp|P35221|CTNA1_HUMAN;tr|G3XAM7|G3XAM7_HUMAN",1446,"P35221","CTNA1_HUMAN","Catenin alpha-1",null,"CTNNA1"]
["24.2221","22.8497","23.4148","23.0635","22.0172","23.2798",{"$nulls":3},"protein glycosylation","dolichyl-diphosphooligosaccharide-protein glycotransferase activity","integral component of membrane;oligosaccharyltransferase complex",{"$nulls":3},3,3,3,"37.6","37.6","37.6","9.5541",0,"24.739",667910000,29,"0.564815",1,"0.708729","1.27171","tr|F5GXX5|F5GXX5_HUMAN;sp|P61803|DAD1_HUMAN;tr|F5H895|F5H895_HUMAN;tr|A0A0B4J239|A0A0B4J239_HUMAN","tr|F5GXX5|F5GXX5_HUMAN;sp|P61803|DAD1_HUMAN;tr|F5H895|F5H895_HUMAN;tr|A0A0B4J239|A0A0B4J239_HUMAN",1940,"F5GXX5","F5GXX5_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 {ECO:0000256|RuleBase:RU361136}","ligosaccharyl transferase subunit DAD1 {ECO:0000256|RuleBase:RU361136}","DAD1"]
["21.7699","21.3003","21.9381","20.9194","20.3107","21.6567",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;mRNA splicing, via spliceosome;mRNA stabilization;multicellular organism development;negative regulation of gene silencing by miRNA;positive regulation of translation;regulation of mRNA stability;regulation of stem cell population maintenance","AU-rich element binding;double-stranded RNA binding;mRNA 3'-UTR AU-rich region binding;mRNA 3'-UTR binding;mRNA binding;protein homodimerization activity;protein kinase binding;RNA binding","cytoplasm;cytosol;membrane;nucleoplasm;nucleus;ribonucleoprotein complex","AMPK signaling pathway;IL-17 signaling pathway",null,null,10,10,10,"41.1","41.1","41.1","36.091",0,"37.857",544500000,50,"0.749303",1,"0.707136","1.63153","sp|Q15717|ELAV1_HUMAN;tr|M0QZR9|M0QZR9_HUMAN;tr|M0R055|M0R055_HUMAN;tr|B1AM48|B1AM48_HUMAN;sp|Q12926|ELAV2_HUMAN;tr|B1APY9|B1APY9_HUMAN;sp|P26378|ELAV4_HUMAN;tr|B1APY8|B1APY8_HUMAN;tr|A0A0A0MRX1|A0A0A0MRX1_HUMAN","sp|Q15717|ELAV1_HUMAN;tr|M0QZR9|M0QZR9_HUMAN",2634,"Q15717","ELAV1_HUMAN","ELAV-like protein 1",null,"ELAVL1"]
["25.2708","22.8264","23.8643","23.8643","22.5186","23.4584",{"$nulls":3},"adenine salvage;AMP salvage;cellular response to insulin stimulus;grooming behavior;lactation;neutrophil degranulation;purine ribonucleoside salvage;purine-containing compound salvage","adenine binding;adenine phosphoribosyltransferase activity;AMP binding","cytoplasm;cytosol;extracellular exosome;extracellular region;nucleoplasm;secretory granule lumen","Metabolic pathways;Purine metabolism",null,null,10,10,10,"71.1","71.1","71.1","19.608",0,"280.93",1834300000,69,"0.362915",1,"0.706745","0.869587","sp|P07741|APT_HUMAN;tr|H3BQF1|H3BQF1_HUMAN;tr|H3BQZ9|H3BQZ9_HUMAN;tr|H3BQB1|H3BQB1_HUMAN;tr|H3BSW3|H3BSW3_HUMAN","sp|P07741|APT_HUMAN;tr|H3BQF1|H3BQF1_HUMAN;tr|H3BQZ9|H3BQZ9_HUMAN;tr|H3BQB1|H3BQB1_HUMAN",943,"P07741","APT_HUMAN","Adenine phosphoribosyltransferase","PRT","APRT"]
["29.9898","29.0365","29.3826","29.1884","28.1678","28.9334",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic mitochondrial changes;B cell activation;B cell cytokine production;B cell proliferation;chaperone-mediated protein complex assembly;chaperone-mediated protein folding;'de novo' protein folding;interaction with symbiont;isotype switching to IgG isotypes;MyD88-dependent toll-like receptor signaling pathway;negative regulation of apoptotic process;positive regulation of apoptotic process;positive regulation of interferon-alpha production;positive regulation of interferon-gamma production;positive regulation of interleukin-10 production;positive regulation of interleukin-12 production;positive regulation of interleukin-6 production;positive regulation of macrophage activation;positive regulation of T cell activation;positive regulation of T cell mediated immune response to tumor cell;protein import into mitochondrial intermembrane space;protein maturation;protein refolding;protein stabilization;regulation of transcription from RNA polymerase II promoter;response to cold;response to unfolded protein;T cell activation;viral process","apolipoprotein A-I binding;apolipoprotein binding;ATP binding;ATPase activity;chaperone binding;DNA replication origin binding;double-stranded RNA binding;enzyme binding;high-density lipoprotein particle binding;lipopolysaccharide binding;p53 binding;protein binding involved in protein folding;RNA binding;single-stranded DNA binding;ubiquitin protein ligase binding;unfolded protein binding","cell surface;clathrin-coated pit;coated vesicle;cytoplasm;cytosol;early endosome;extracellular exosome;extracellular matrix;extracellular space;lipopolysaccharide receptor complex;membrane;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;myelin sheath;plasma membrane;protein complex;secretory granule","Legionellosis;RNA degradation;Tuberculosis;Type I diabetes mellitus",null,null,43,43,43,"72.6","72.6","72.6","61.054",0,"323.31",{"v":1800100000000000,"d":"1.80E+15"},2087,"0.786771",1,"0.706436","1.70502","sp|P10809|CH60_HUMAN;tr|E7ESH4|E7ESH4_HUMAN;tr|E7EXB4|E7EXB4_HUMAN;tr|C9JL25|C9JL25_HUMAN;tr|C9JL19|C9JL19_HUMAN;tr|C9JCQ4|C9JCQ4_HUMAN;tr|C9J0S9|C9J0S9_HUMAN","sp|P10809|CH60_HUMAN",1029,"P10809","CH60_HUMAN","60 kDa heat shock protein, mitochondrial",null,"HSPD1"]
["26.3878","24.1397","24.8842","25.0624","23.6619","24.57",{"$nulls":3},"cell redox homeostasis;cellular response to oxidative stress;cellular response to reactive oxygen species;hydrogen peroxide catabolic process;inflammatory response;NADPH oxidation;negative regulation of apoptotic process;negative regulation of oxidoreductase activity;negative regulation of transcription from RNA polymerase III promoter;positive regulation of collagen biosynthetic process;reactive nitrogen species metabolic process;regulation of apoptosis involved in tissue homeostasis;response to oxidative stress","antioxidant activity;cysteine-type endopeptidase inhibitor activity involved in apoptotic process;peroxidase activity;peroxiredoxin activity;peroxynitrite reductase activity;protein dimerization activity;receptor binding;RNA polymerase III regulatory region DNA binding;thioredoxin peroxidase activity","cytoplasm;cytoplasmic vesicle;cytosol;extracellular exosome;extracellular space;intracellular membrane-bounded organelle;mitochondrial matrix;mitochondrion;nucleus;perinuclear region of cytoplasm;peroxisomal matrix;peroxisome","Peroxisome",null,null,10,10,10,"56.1","56.1","56.1","22.086",0,"287.63",4361100000,144,"0.381252",1,"0.705786","0.907077","sp|P30044|PRDX5_HUMAN","sp|P30044|PRDX5_HUMAN",1368,"P30044","PRDX5_HUMAN","Peroxiredoxin-5, mitochondrial",null,"PRDX5"]
["18.1404","16.2333","17.2575","17.4398","15.8368","16.2379",{"$nulls":3},"phosphatidylglycerol acyl-chain remodeling;phospholipid biosynthetic process;positive regulation of fatty acid biosynthetic process","1-acylglycerol-3-phosphate O-acyltransferase activity;2-acylglycerol-3-phosphate O-acyltransferase activity","cytoplasm;endoplasmic reticulum membrane;integral component of membrane;membrane","Glycerophospholipid metabolism",null,null,2,2,2,"6.5","6.5","6.5","43.089","0.00041982","4.4679",31012000,1,"0.409366",1,"0.705535","0.96405","sp|Q92604|LGAT1_HUMAN","sp|Q92604|LGAT1_HUMAN",3688,"Q92604","LGAT1_HUMAN","Acyl-CoA:lysophosphatidylglycerol acyltransferase 1",null,"LPGAT1"]
["20.6227","20.3119","20.756","20.2585","18.9181","20.3978",{"$nulls":4},"RNA binding","mRNA cleavage factor complex",{"$nulls":3},9,9,9,"33.4","33.4","33.4","41.265",0,"52.044",280310000,43,"0.65133",1,"0.705409","1.44038","tr|F5H669|F5H669_HUMAN;sp|Q8N684|CPSF7_HUMAN;tr|F5H6M0|F5H6M0_HUMAN;tr|F5H047|F5H047_HUMAN;tr|J3QT54|J3QT54_HUMAN;tr|C9J286|C9J286_HUMAN;tr|C9J323|C9J323_HUMAN;tr|C9JM38|C9JM38_HUMAN;tr|F5H5B7|F5H5B7_HUMAN;tr|F5H1W4|F5H1W4_HUMAN;tr|F5H2K8|F5H2K8_HUMAN;tr|F5H6P5|F5H6P5_HUMAN;tr|F5H6A8|F5H6A8_HUMAN;tr|F5GXA3|F5GXA3_HUMAN","tr|F5H669|F5H669_HUMAN;sp|Q8N684|CPSF7_HUMAN;tr|F5H6M0|F5H6M0_HUMAN;tr|F5H047|F5H047_HUMAN;tr|J3QT54|J3QT54_HUMAN",3423,"F5H669","F5H669_HUMAN",null,null,"CPSF7"]
["23.6659","23.541","23.0294","22.8701","22.7987","22.4536",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"13.5","13.5","13.5","14.265",0,"10.891",259110000,9,"1.40712",1,"0.704663","3.01999","tr|F8VNT9|F8VNT9_HUMAN;tr|F8VV56|F8VV56_HUMAN;tr|F8W022|F8W022_HUMAN;tr|F8VWK8|F8VWK8_HUMAN;sp|P08962|CD63_HUMAN","tr|F8VNT9|F8VNT9_HUMAN;tr|F8VV56|F8VV56_HUMAN;tr|F8W022|F8W022_HUMAN;tr|F8VWK8|F8VWK8_HUMAN;sp|P08962|CD63_HUMAN",977,"F8VNT9","F8VNT9_HUMAN",null,null,"CD63"]
["20.0617","18.7664","19.4944","20.1836","17.4017","18.6245",{"$nulls":3},"cellular respiration;heme a biosynthetic process;heme biosynthetic process;hydrogen ion transmembrane transport;mitochondrial electron transport, cytochrome c to oxygen;oxidation-reduction process;respiratory chain complex IV assembly;respiratory gaseous exchange","cytochrome-c oxidase activity;oxidoreductase activity, acting on the CH-CH group of donors","cytochrome complex;integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrion;nucleus","Metabolic pathways;Oxidative phosphorylation;Porphyrin and chlorophyll metabolism;Thermogenesis",null,null,6,6,6,"18.8","18.8","18.8","46.03",0,"18.444",179780000,20,"0.325923",1,"0.704221","0.793026","sp|Q7KZN9|COX15_HUMAN","sp|Q7KZN9|COX15_HUMAN",3113,"Q7KZN9","COX15_HUMAN","Cytochrome c oxidase assembly protein COX15 homolog",null,"COX15"]
["19.8825","18.1712","20.0927","19.9221","17.3421","18.7773",{"$nulls":3},"mRNA 3'-end processing;mRNA splicing, via spliceosome;termination of RNA polymerase II transcription","RNA binding","nucleoplasm","mRNA surveillance pathway",null,null,6,6,6,"20.9","20.9","20.9","48.357",0,"20.815",106160000,19,"0.295332",1,"0.701633","0.728615","sp|Q05048|CSTF1_HUMAN;tr|A0A0A0MSZ9|A0A0A0MSZ9_HUMAN;tr|A3KFI9|A3KFI9_HUMAN","sp|Q05048|CSTF1_HUMAN;tr|A0A0A0MSZ9|A0A0A0MSZ9_HUMAN",2192,"Q05048","CSTF1_HUMAN","Cleavage stimulation factor subunit 1",null,"CSTF1"]
["20.3941","20.0807","21.0574","18.4401","19.8305","21.1678",{"$nulls":3},"cell division;centriole replication;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;global genome nucleotide-excision repair;mitotic cell cycle;nucleotide-excision repair;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, preincision complex assembly;regulation of cytokinesis;regulation of G2/M transition of mitotic cell cycle;spermatogenesis","calcium ion binding;G-protein beta/gamma-subunit complex binding;heterotrimeric G-protein binding;microtubule binding","centriole;centrosome;ciliary basal body;cytosol;intracellular;nucleoplasm;photoreceptor connecting cilium;XPC complex","Nucleotide excision repair",null,null,8,8,8,"57.6","57.6","57.6","19.738",0,"294.75",680720000,40,"0.344861",1,"0.697914","0.832388","sp|P41208|CETN2_HUMAN;sp|Q12798|CETN1_HUMAN","sp|P41208|CETN2_HUMAN",1530,"P41208","CETN2_HUMAN","Centrin-2",null,"CETN2"]
["23.4695","22.3714","23.3786","22.6488","21.6755","22.805",{"$nulls":3},"autophagy of mitochondrion;calcium-mediated signaling using intracellular calcium source;cellular response to glucose stimulus;cellular response to peptide;cellular response to thapsigargin;cellular response to toxic substance;mitochondrial fission;mitochondrial fragmentation involved in apoptotic process;mitochondrial fusion;mitochondrion morphogenesis;negative regulation of endoplasmic reticulum calcium ion concentration;peroxisome fission;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cytosolic calcium ion concentration;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial calcium ion concentration;positive regulation of mitochondrial fission;positive regulation of neuron apoptotic process;positive regulation of protein targeting to membrane;protein homooligomerization;protein targeting to mitochondrion;regulation of mitochondrion organization;release of cytochrome c from mitochondria;response to flavonoid;response to fluoride;response to hypobaric hypoxia;response to muscle activity;response to nutrient levels","protein complex binding;receptor binding","endoplasmic reticulum;integral component of mitochondrial outer membrane;integral component of peroxisomal membrane;membrane;mitochondrion;peroxisome;protein complex","Mitophagy - animal",null,null,3,3,3,"26.3","26.3","26.3","16.937",0,"65.78",436720000,25,"0.629139",1,"0.696733","1.39716","sp|Q9Y3D6|FIS1_HUMAN","sp|Q9Y3D6|FIS1_HUMAN",5293,"Q9Y3D6","FIS1_HUMAN","Mitochondrial fission 1 protein",null,"FIS1"]
["23.1121","21.5192","22.8403","22.0716","20.5931","22.7248",{"$nulls":3},"box C/D snoRNP assembly;maturation of LSU-rRNA;maturation of SSU-rRNA;mRNA splicing, via spliceosome;rRNA processing;single fertilization","ATPase binding;box C/D snoRNA binding;RNA binding;U3 snoRNA binding;U4 snRNA binding;U4atac snRNA binding","box C/D snoRNP complex;dense fibrillar component;nucleolus;nucleoplasm;nucleus;precatalytic spliceosome;protein complex;small-subunit processome;U4/U6 x U5 tri-snRNP complex","Ribosome biogenesis in eukaryotes;Spliceosome",null,null,5,5,5,"39.8","39.8","39.8","14.173",0,"62.959",556390000,33,"0.362024",1,"0.694009","0.867757","sp|P55769|NH2L1_HUMAN;tr|B1AHD1|B1AHD1_HUMAN","sp|P55769|NH2L1_HUMAN;tr|B1AHD1|B1AHD1_HUMAN",1851,"P55769","NH2L1_HUMAN","NHP2-like protein 1",null,"SNU13"]
["24.334","22.1966","22.2217","23.3789","21.5148","21.7788",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;retrograde vesicle-mediated transport, Golgi to ER;toxin transport",null,"COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi membrane;transport vesicle",{"$nulls":3},5,5,5,35,35,35,"20.198",0,"36.823",280500000,19,"0.308294",1,"0.693271","0.756041","sp|P61923|COPZ1_HUMAN;tr|F8VVA7|F8VVA7_HUMAN;tr|F8W651|F8W651_HUMAN;tr|F8VXB1|F8VXB1_HUMAN;tr|F8VUC5|F8VUC5_HUMAN;tr|F8W156|F8W156_HUMAN;tr|F8VYZ4|F8VYZ4_HUMAN;tr|F8VYK5|F8VYK5_HUMAN;tr|F8VXR1|F8VXR1_HUMAN","sp|P61923|COPZ1_HUMAN;tr|F8VVA7|F8VVA7_HUMAN;tr|F8W651|F8W651_HUMAN;tr|F8VXB1|F8VXB1_HUMAN;tr|F8VUC5|F8VUC5_HUMAN;tr|F8W156|F8W156_HUMAN;tr|F8VYZ4|F8VYZ4_HUMAN",1942,"P61923","COPZ1_HUMAN","Coatomer subunit zeta-1",null,"COPZ1"]
["23.6218","21.0612","22.3768","22.106","20.8214","22.0528",{"$nulls":3},"cell redox homeostasis;cyclooxygenase pathway;neutrophil degranulation;positive regulation of transcription, DNA-templated","DNA binding;electron transfer activity;glutathione binding;heme binding;lyase activity;prostaglandin-E synthase activity;protein disulfide oxidoreductase activity","azurophil granule lumen;cytosol;extracellular region;Golgi membrane;integral component of membrane;mitochondrion;nucleus;perinuclear region of cytoplasm","Arachidonic acid metabolism;Metabolic pathways",null,null,15,15,15,48,48,48,"41.943",0,"213.24",1302400000,82,"0.336718",1,"0.693219","0.815507","sp|Q9H7Z7|PGES2_HUMAN;tr|A6NHH0|A6NHH0_HUMAN;tr|X6RJ95|X6RJ95_HUMAN","sp|Q9H7Z7|PGES2_HUMAN;tr|A6NHH0|A6NHH0_HUMAN",4512,"Q9H7Z7","PGES2_HUMAN","Prostaglandin E synthase 2",null,"PTGES2"]
["23.3098","22.4586","22.7566","22.4208","21.5683","22.4645",{"$nulls":3},"alternative mRNA splicing, via spliceosome;androgen receptor signaling pathway;defense response to virus;epithelial to mesenchymal transition;gene silencing by RNA;intracellular estrogen receptor signaling pathway;miRNA metabolic process;myoblast differentiation;positive regulation of transcription from RNA polymerase II promoter;regulation of alternative mRNA splicing, via spliceosome;regulation of skeletal muscle cell differentiation;regulation of transcription from RNA polymerase II promoter;RNA processing;RNA secondary structure unwinding;rRNA processing;transcription, DNA-templated","ATP binding;ATP-dependent RNA helicase activity;RNA binding;RNA helicase activity;RNA-dependent ATPase activity;transcription coactivator activity","cytoplasm;cytosol;membrane;nuclear speck;nucleolus;nucleoplasm;nucleus",{"$nulls":3},31,23,23,"48.4","36.8","36.8","80.272",0,"241.85",2712100000,165,"0.834485",1,"0.690454","1.7991","sp|Q92841|DDX17_HUMAN;tr|H3BLZ8|H3BLZ8_HUMAN","sp|Q92841|DDX17_HUMAN;tr|H3BLZ8|H3BLZ8_HUMAN",3723,"Q92841","DDX17_HUMAN","Probable ATP-dependent RNA helicase DDX17",null,"DDX17"]
["21.1716","20.362","20.2672","20.3884","19.6539","19.6953",{"$nulls":3},"cell junction assembly;muscle fiber development","actin filament binding;ankyrin binding;cytoskeletal protein binding;identical protein binding","costamere;cytoplasm;cytoskeleton;cytosol;focal adhesion;plasma membrane;sarcolemma;sarcoplasm;Z disc","Focal adhesion;MAPK signaling pathway;Proteoglycans in cancer;Salmonella infection",null,null,72,58,58,"35.4","30.2","30.2","291.02",0,"277.58",2112200000,168,"0.857056",1,"0.687731","1.84385","sp|Q14315|FLNC_HUMAN","sp|Q14315|FLNC_HUMAN",2464,"Q14315","FLNC_HUMAN","Filamin-C","LNc;LN-C","FLNC"]
["22.6955","21.3597","21.5655","21.972","20.6344","20.956",{"$nulls":3},"seryl-tRNA aminoacylation","ATP binding;serine-tRNA ligase activity","cytoplasm",{"$nulls":3},18,18,18,"49.2","49.2","49.2","58.182",0,"189.04",950340000,82,"0.520811",1,"0.686087","1.1855","tr|M0QWZ7|M0QWZ7_HUMAN;sp|Q9NP81|SYSM_HUMAN;tr|M0R2C6|M0R2C6_HUMAN;tr|M0R259|M0R259_HUMAN;tr|B4DJM9|B4DJM9_HUMAN;tr|M0QX29|M0QX29_HUMAN;tr|M0R1C0|M0R1C0_HUMAN;tr|M0R2H5|M0R2H5_HUMAN","tr|M0QWZ7|M0QWZ7_HUMAN;sp|Q9NP81|SYSM_HUMAN;tr|M0R2C6|M0R2C6_HUMAN;tr|M0R259|M0R259_HUMAN",4626,"M0QWZ7","M0QWZ7_HUMAN"]
["17.3381","17.3509","16.3303","15.496","15.7462","17.7386",{"$nulls":3},"transmembrane transport","actin binding;calmodulin binding;structural constituent of cytoskeleton","brush border;cell cortex;cell-cell junction;condensed nuclear chromosome;cytoskeleton;cytosol;membrane;nucleoplasm;plasma membrane;postsynaptic density",{"$nulls":3},12,12,12,"26.2","26.2","26.2","79.154",0,"26.616",190270000,29,"0.360467",1,"0.679501","0.864561","sp|Q9UEY8|ADDG_HUMAN;tr|A0A087WX08|A0A087WX08_HUMAN","sp|Q9UEY8|ADDG_HUMAN;tr|A0A087WX08|A0A087WX08_HUMAN",4994,"Q9UEY8","ADDG_HUMAN","Gamma-adducin",null,"ADD3"]
["19.6316",1,"18.0475","19.2248",1,"16.4233",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic mitochondrial changes;establishment of protein localization to membrane;extrinsic apoptotic signaling pathway via death domain receptors;hepatocyte apoptotic process;mitochondrial ATP synthesis coupled electron transport;mitochondrial outer membrane permeabilization;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;neuron apoptotic process;positive regulation of apoptotic process;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of fibroblast apoptotic process;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial membrane potential;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of protein homooligomerization;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;positive regulation of protein oligomerization;positive regulation of release of cytochrome c from mitochondria;protein homooligomerization;protein targeting to mitochondrion;regulation of apoptotic process;regulation of cell proliferation;regulation of G1/S transition of mitotic cell cycle;release of cytochrome c from mitochondria;signal transduction in response to DNA damage","death receptor binding;protein heterodimerization activity;ubiquitin protein ligase binding","cytosol;extracellular exosome;integral component of mitochondrial membrane;membrane;mitochondrial outer membrane;mitochondrion","Alzheimer disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Apoptosis - multiple species;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;Natural killer cell mediated cytotoxicity;Necroptosis;Non-alcoholic fatty liver disease (NAFLD);p53 signaling pathway;Pathways in cancer;Platinum drug resistance;Sphingolipid signaling pathway;Tuberculosis;Viral myocarditis",null,null,3,3,3,"22.1","22.1","22.1","21.994",0,"8.5571",18564000,4,"0.0276269",1,"0.676971","0.0822923","sp|P55957|BID_HUMAN","sp|P55957|BID_HUMAN",1858,"P55957","BID_HUMAN","BH3-interacting domain death agonist",null,"BID"]
["20.1203","20.0351","20.5037","19.517","19.0983","20.0158",{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;RNA localization;RNA splicing;RNA splicing, via transesterification reactions;spliceosomal complex assembly;spliceosomal tri-snRNP complex assembly","androgen receptor binding;ribonucleoprotein complex binding;RNA binding;transcription coactivator activity","catalytic step 2 spliceosome;membrane;nuclear speck;nucleoplasm;nucleus;spliceosomal complex;U4/U6 x U5 tri-snRNP complex;U5 snRNP","Spliceosome",null,null,38,38,38,"45.9","45.9","45.9","106.92",0,"319.01",3735400000,283,"1.05239",1,"0.676037","2.23987","sp|O94906|PRP6_HUMAN","sp|O94906|PRP6_HUMAN",691,"O94906","PRP6_HUMAN","Pre-mRNA-processing factor 6",null,"PRPF6"]
["18.9796","18.0593","18.0706","18.3199","17.2877","17.4863",{"$nulls":3},"activation of GTPase activity;autophagy;intracellular protein transport;macroautophagy;positive regulation of receptor internalization;regulation of vesicle fusion;response to starvation;retrograde transport, endosome to Golgi","AP-2 adaptor complex binding;GTPase activator activity;Rab GTPase binding;retromer complex binding","autophagosome;cytosol;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;retromer complex",{"$nulls":3},6,6,6,"14.7","14.7","14.7","89.003",0,"60.202",103810000,14,"0.697139",1,"0.671904","1.52964","sp|Q92609|TBCD5_HUMAN;tr|C9J3F6|C9J3F6_HUMAN;tr|C9JMP7|C9JMP7_HUMAN;tr|C9JIU4|C9JIU4_HUMAN;tr|F2Z3I5|F2Z3I5_HUMAN;tr|C9JNM0|C9JNM0_HUMAN;tr|C9JED7|C9JED7_HUMAN;tr|F2Z3C3|F2Z3C3_HUMAN;tr|C9K0P2|C9K0P2_HUMAN;tr|C9J397|C9J397_HUMAN;tr|C9JWX0|C9JWX0_HUMAN;tr|C9JW04|C9JW04_HUMAN;tr|C9JDR8|C9JDR8_HUMAN","sp|Q92609|TBCD5_HUMAN;tr|C9J3F6|C9J3F6_HUMAN",3689,"Q92609","TBCD5_HUMAN","TBC1 domain family member 5",null,"TBC1D5"]
["20.7423","19.1184","16.0939","19.8121","18.4186","15.711",{"$nulls":3},"rRNA 2'-O-methylation","RNA binding;rRNA (guanosine-2'-O-)-methyltransferase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},3,3,3,"13.1","13.1","13.1","47.019",0,"10.718",89740000,6,"0.136219",1,"0.670961","0.369087","sp|Q9HC36|MRM3_HUMAN;tr|I3L0T6|I3L0T6_HUMAN;tr|I3L443|I3L443_HUMAN","sp|Q9HC36|MRM3_HUMAN",4584,"Q9HC36","MRM3_HUMAN","rRNA methyltransferase 3, mitochondrial {ECO:0000303|PubMed:25009282}",null,"MRM3"]
["21.4754","22.9496","21.164","20.237","22.1976","21.1444",{"$nulls":3},"oxidation-reduction process",null,"mitochondrial inner membrane;respiratory chain",{"$nulls":3},5,5,5,"43.8","43.8","43.8","15.136",0,"20.067",544310000,34,"0.35246",1,"0.670017","0.848081","tr|A0A0C4DGS0|A0A0C4DGS0_HUMAN;sp|P56556|NDUA6_HUMAN;tr|R4GN43|R4GN43_HUMAN","tr|A0A0C4DGS0|A0A0C4DGS0_HUMAN;sp|P56556|NDUA6_HUMAN;tr|R4GN43|R4GN43_HUMAN",1869,"A0A0C4DGS0","A0A0C4DGS0_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 {ECO:0000256|PIRNR:PIRNR006643}",null,"NDUFA6"]
["21.9663","20.0254","20.7826","20.2463","19.6507","20.8776",{"$nulls":3},"CUT catabolic process;DNA deamination;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);isotype switching;nuclear polyadenylation-dependent rRNA catabolic process;nuclear polyadenylation-dependent tRNA catabolic process;nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';polyadenylation-dependent snoRNA 3'-end processing;positive regulation of isotype switching;regulation of mRNA stability;rRNA processing;U4 snRNA 3'-end processing","3'-5'-exoribonuclease activity;RNA binding","cytoplasm;cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);nuclear exosome (RNase complex);nucleolus;nucleoplasm;nucleus;transcriptionally active chromatin","RNA degradation",null,null,7,7,7,"44.7","44.7","44.7","29.572",0,"81.154",210970000,23,"0.427173",1,"0.666567","0.999858","sp|Q9NQT5|EXOS3_HUMAN","sp|Q9NQT5|EXOS3_HUMAN",4662,"Q9NQT5","EXOS3_HUMAN","Exosome complex component RRP40",null,"EXOSC3"]
["20.5915","18.9628","18.7336","19.07","18.7167","18.5072",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;eosinophil chemotaxis;epithelial cell differentiation;innate immune response;killing of cells of other organism;macrophage chemotaxis;monocyte chemotaxis;mononuclear cell migration;mRNA processing;negative regulation of endocytosis;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of immunological synapse formation;negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;negative regulation of T cell receptor signaling pathway;neutrophil chemotaxis;neutrophil degranulation;positive chemotaxis;positive regulation of calcium ion import;positive regulation of mononuclear cell migration;regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of myeloid cell differentiation;regulation of T cell apoptotic process;regulation of T cell proliferation;RNA splicing","carbohydrate binding;chemoattractant activity;IgE binding;laminin binding;oligosaccharide binding;RNA binding","cytoplasm;extracellular exosome;extracellular matrix;extracellular region;extracellular space;ficolin-1-rich granule membrane;immunological synapse;membrane;mitochondrial inner membrane;nucleus;other organism cell;plasma membrane;secretory granule membrane;spliceosomal complex",{"$nulls":3},5,5,5,"21.2","21.2","21.2","26.152",0,"10.102",55748000,6,"0.474519",1,"0.664693","1.0942","sp|P17931|LEG3_HUMAN;tr|G3V3R6|G3V3R6_HUMAN","sp|P17931|LEG3_HUMAN;tr|G3V3R6|G3V3R6_HUMAN",1167,"P17931","LEG3_HUMAN","Galectin-3","al-3","LGALS3"]
["20.269","18.6789","18.1715","19.9505","16.6124","18.5681",{"$nulls":3},"box C/D snoRNA 3'-end processing;histone glutamine methylation;osteoblast differentiation;rRNA methylation;rRNA processing;snoRNA localization;tRNA processing","ATPase binding;histone-glutamine methyltransferase activity;RNA binding;rRNA methyltransferase activity;TFIID-class transcription factor binding","box C/D snoRNP complex;Cajal body;chromosome;dense fibrillar component;extracellular exosome;fibrillar center;granular component;membrane;nucleolus;nucleoplasm;nucleus;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,8,8,5,"32.4","32.4","20.6","33.784",0,"28.077",472050000,59,"0.223909",1,"0.662821","0.573254","sp|P22087|FBRL_HUMAN;tr|M0R299|M0R299_HUMAN;tr|M0QXL5|M0QXL5_HUMAN;tr|M0R0P1|M0R0P1_HUMAN;tr|M0R2Q4|M0R2Q4_HUMAN;tr|M0R2U2|M0R2U2_HUMAN;tr|M0R1H0|M0R1H0_HUMAN;tr|M0R2B0|M0R2B0_HUMAN","sp|P22087|FBRL_HUMAN;tr|M0R299|M0R299_HUMAN;tr|M0QXL5|M0QXL5_HUMAN;tr|M0R0P1|M0R0P1_HUMAN;tr|M0R2Q4|M0R2Q4_HUMAN",1240,"P22087","FBRL_HUMAN","rRNA 2'-O-methyltransferase fibrillarin",null,"FBL"]
["21.9034","22.4429","21.235","19.3447","22.8107","21.4507",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","rRNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,8,8,8,"30.3","30.3","30.3","28.449",0,"44.609",1472600000,100,"0.24367",1,"0.658412","0.617043","sp|Q9NX20|RM16_HUMAN;tr|E9PI14|E9PI14_HUMAN","sp|Q9NX20|RM16_HUMAN",4808,"Q9NX20","RM16_HUMAN","39S ribosomal protein L16, mitochondrial","16mt;RP-L16","MRPL16"]
["18.8569","18.5692","19.1191","19.4485","16.9305","18.1926",{"$nulls":9},2,2,2,"7.7","7.7","7.7","38.37","0.0004223","4.611",79014000,6,"0.370039",1,"0.657861","0.884185","tr|A0A0D9SFR5|A0A0D9SFR5_HUMAN;tr|H3BQ06|H3BQ06_HUMAN;sp|Q9ULP9|TBC24_HUMAN","tr|A0A0D9SFR5|A0A0D9SFR5_HUMAN;tr|H3BQ06|H3BQ06_HUMAN;sp|Q9ULP9|TBC24_HUMAN",5128,"A0A0D9SFR5","A0A0D9SFR5_HUMAN",null,null,"TBC1D24"]
["24.9039","23.0147","23.2724","23.9111","22.4002","22.9108",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cilium assembly;ER to Golgi vesicle-mediated transport;intraciliary transport involved in cilium assembly;macroautophagy;positive regulation of ATP-dependent microtubule motor activity, plus-end-directed;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;sister chromatid cohesion;transport along microtubule","cytoskeletal protein binding;dynein intermediate chain binding;dynein light intermediate chain binding;motor activity;protein heterodimerization activity;protein homodimerization activity;scaffold protein binding","centrosome;ciliary tip;cilium;cytoplasmic dynein complex;cytosol;membrane;microtubule;mitochondrion;myosin complex;myosin V complex;nucleus;plasma membrane","Vasopressin-regulated water reabsorption",null,null,4,4,2,"57.3","57.3","32.6","10.35",0,"45.341",494770000,25,"0.371697",1,"0.656294","0.887576","sp|Q96FJ2|DYL2_HUMAN","sp|Q96FJ2|DYL2_HUMAN",3876,"Q96FJ2","DYL2_HUMAN","Dynein light chain 2, cytoplasmic",null,"DYNLL2"]
["20.8283","19.9755","20.6229","19.8029","19.3374","20.3237",{"$nulls":3},"alternative mRNA splicing, via spliceosome;DNA repair;mRNA splicing, via spliceosome;regulation of RNA splicing","RNA binding","nucleoplasm;protein complex;spliceosomal complex","Spliceosome",null,null,14,14,14,"45.1","45.1","45.1","44.961",0,"48.249",648750000,76,"0.78693",1,"0.654249","1.70533","sp|Q96I25|SPF45_HUMAN;tr|Q5W011|Q5W011_HUMAN;tr|Q5W010|Q5W010_HUMAN;tr|Q5W012|Q5W012_HUMAN;tr|H0Y6J6|H0Y6J6_HUMAN","sp|Q96I25|SPF45_HUMAN;tr|Q5W011|Q5W011_HUMAN;tr|Q5W010|Q5W010_HUMAN;tr|Q5W012|Q5W012_HUMAN",3921,"Q96I25","SPF45_HUMAN","Splicing factor 45",null,"RBM17"]
["25.359","22.3048","25.1105","25.0651","20.9513","24.7953",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;mitochondrial respiratory chain complex III assembly","ubiquinol-cytochrome-c reductase activity","extracellular exosome;mitochondrial inner membrane;mitochondrial respiratory chain complex III","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,2,2,2,"38.1","38.1","38.1","7.3084",0,"23.438",1634600000,74,"0.147475",1,"0.654197","0.396362","sp|Q9UDW1|QCR9_HUMAN;tr|Q9NZY4|Q9NZY4_HUMAN","sp|Q9UDW1|QCR9_HUMAN;tr|Q9NZY4|Q9NZY4_HUMAN",4983,"Q9UDW1","QCR9_HUMAN","Cytochrome b-c1 complex subunit 9",null,"UQCR10"]
["16.7581","13.936","15.7135","16.2465","13.3071","14.9045",{"$nulls":3},"mRNA splicing, via spliceosome;transcription-coupled nucleotide-excision repair","RNA binding","catalytic step 2 spliceosome;membrane;nucleoplasm","Spliceosome",null,null,4,4,4,"3.4","3.4","3.4","171.29",0,"7.6407",47392000,4,"0.213162",1,"0.649861","0.549143","sp|O60306|AQR_HUMAN","sp|O60306|AQR_HUMAN",484,"O60306","AQR_HUMAN","Intron-binding protein aquarius",null,"AQR"]
["20.4545","20.0828","19.9398","20.4034","18.5317","19.5959",{"$nulls":3},"cell cycle arrest;intrinsic apoptotic signaling pathway;maturation of 5S rRNA;mRNA cis splicing, via spliceosome;mRNA splicing, via spliceosome;positive regulation of cytotoxic T cell differentiation;spliceosomal snRNP assembly","RNA binding","Cajal body;catalytic step 2 spliceosome;cytoplasm;cytosol;Golgi apparatus;nuclear speck;nucleoplasm;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,30,30,30,"51.8","51.8","51.8","90.254",0,"323.31",2769600000,228,"0.503565",1,"0.648695","1.15158","sp|O43290|SNUT1_HUMAN;tr|E9PQI8|E9PQI8_HUMAN","sp|O43290|SNUT1_HUMAN",401,"O43290","SNUT1_HUMAN","U4/U6.U5 tri-snRNP-associated protein 1",null,"SART1"]
["20.374","16.6276","19.5871","19.4712","16.2397","18.9356",{"$nulls":4},"identical protein binding","cell junction;extracellular exosome;synaptic vesicle;synaptic vesicle membrane",{"$nulls":3},2,2,2,"16.9","16.9","16.9","30.211",0,"20.838",59076000,5,"0.160217",1,"0.647381","0.426813","sp|Q5T0D9|TPRGL_HUMAN","sp|Q5T0D9|TPRGL_HUMAN",2857,"Q5T0D9","TPRGL_HUMAN","Tumor protein p63-regulated gene 1-like protein",null,"TPRG1L"]
["19.8812","17.5885","18.5728","19.8172","16.5433","17.7434",{"$nulls":3},"retrograde transport, endosome to Golgi",null,"cytosol;Golgi cisterna membrane;integral component of membrane",{"$nulls":3},6,6,6,"11.2","11.2","11.2","63.429",0,"21.039",101550000,17,"0.215776",1,"0.646159","0.555028","sp|Q8NBN3|TM87A_HUMAN;tr|H3BMU0|H3BMU0_HUMAN;tr|H3BM87|H3BM87_HUMAN;tr|H3BSZ0|H3BSZ0_HUMAN;tr|H3BUZ1|H3BUZ1_HUMAN;tr|H3BPJ4|H3BPJ4_HUMAN","sp|Q8NBN3|TM87A_HUMAN",3459,"Q8NBN3","TM87A_HUMAN","Transmembrane protein 87A {ECO:0000305}",null,"TMEM87A"]
["20.3806","19.3916","19.6434","20.0145","18.7591","18.7138",{"$nulls":3},"cell cycle;cell division;cell migration;cytoskeleton organization;mRNA splicing, via spliceosome;regulation of cell shape;regulation of cytokinesis","proline-rich region binding;RNA binding","cytosol;membrane;nuclear matrix;nuclear speck;nucleoplasm;U1 snRNP;U2-type prespliceosome","Spliceosome",null,null,25,25,19,"27.8","27.8","21.8","108.8",0,"173.47",2107500000,169,"0.547327",1,"0.642684","1.2375","sp|O75400|PR40A_HUMAN;tr|F5H578|F5H578_HUMAN;tr|H7C2N3|H7C2N3_HUMAN","sp|O75400|PR40A_HUMAN",584,"O75400","PR40A_HUMAN","Pre-mRNA-processing factor 40 homolog A",null,"PRPF40A"]
["22.8267","20.6549","21.7073","21.5693","20.2634","21.4282",{"$nulls":3},"regulation of cell motility;regulation of microtubule-based process",null,"cytosol;nucleus",{"$nulls":3},10,10,10,"49.5","49.5","49.5","33.733",0,"184.28",500730000,45,"0.356024",1,"0.642654","0.855423","sp|Q9Y316|MEMO1_HUMAN;tr|B5MCI6|B5MCI6_HUMAN","sp|Q9Y316|MEMO1_HUMAN",5265,"Q9Y316","MEMO1_HUMAN","Protein MEMO1",null,"MEMO1"]
["21.0348","18.9488","18.8552","19.0145","18.7695","19.1426",{"$nulls":4},"zinc ion binding",{"$nulls":4},5,5,5,"25.4","25.4","25.4","30.787",0,"13.385",103070000,6,"0.370701",1,"0.637433","0.885539","sp|Q8TCF1|ZFAN1_HUMAN;tr|E5RK75|E5RK75_HUMAN;tr|E5RJ74|E5RJ74_HUMAN;tr|E5RGE5|E5RGE5_HUMAN;tr|E5RI74|E5RI74_HUMAN;tr|E5RIS3|E5RIS3_HUMAN","sp|Q8TCF1|ZFAN1_HUMAN",3552,"Q8TCF1","ZFAN1_HUMAN","AN1-type zinc finger protein 1",null,"ZFAND1"]
["23.3149","21.7483","22.4771","22.2115","20.892","22.5251",{"$nulls":3},"RNA splicing","RNA binding","nuclear speck",{"$nulls":3},6,6,6,"18.5","18.5","18.5","42.316",0,"15.91",478220000,49,"0.39969",1,"0.637248","0.944507","tr|Q5T760|Q5T760_HUMAN;sp|Q05519|SRS11_HUMAN;tr|B4DWT1|B4DWT1_HUMAN;tr|Q5T757|Q5T757_HUMAN;tr|S4R3C4|S4R3C4_HUMAN","tr|Q5T760|Q5T760_HUMAN;sp|Q05519|SRS11_HUMAN;tr|B4DWT1|B4DWT1_HUMAN",2196,"Q5T760","Q5T760_HUMAN",null,null,"SRSF11"]
["21.2698","19.9197","20.7074","20.6432","18.7865","20.5584",{"$nulls":3},"hydrogen sulfide metabolic process;sulfide oxidation, using sulfide:quinone oxidoreductase","quinone binding;sulfide:quinone oxidoreductase activity","mitochondrial inner membrane","Metabolic pathways;Sulfur metabolism",null,null,16,16,16,46,46,46,"49.96",0,"103.14",1586900000,143,"0.369261",1,"0.636252","0.882594","sp|Q9Y6N5|SQRD_HUMAN;tr|H3BNX3|H3BNX3_HUMAN;tr|H3BMS6|H3BMS6_HUMAN;tr|H3BNP9|H3BNP9_HUMAN;tr|A0A0K0K1E6|A0A0K0K1E6_HUMAN;tr|H3BV36|H3BV36_HUMAN","sp|Q9Y6N5|SQRD_HUMAN;tr|H3BNX3|H3BNX3_HUMAN",5419,"Q9Y6N5","SQOR_HUMAN","Sulfide:quinone oxidoreductase, mitochondrial {ECO:0000305}","QOR {ECO:0000312|HGNC:HGNC:20390}","SQOR"]
["24.2425","22.7475","23.1894","23.5182","22.0579","22.6984",{"$nulls":3},"acyl-CoA metabolic process;protein homotetramerization","acyl-CoA hydrolase activity","cytoplasm;cytosol;extracellular exosome;mitochondrion;nucleus;spindle",{"$nulls":3},5,5,5,"43.6","43.6","43.6","14.96",0,"17.416",426290000,19,"0.445507",1,"0.634938","1.03653","sp|Q9NPJ3|ACO13_HUMAN","sp|Q9NPJ3|ACO13_HUMAN",4643,"Q9NPJ3","ACO13_HUMAN","Acyl-coenzyme A thioesterase 13","cyl-CoA thioesterase 13","ACOT13"]
["22.9931","22.1311","22.7254","22.4908","21.1299","22.3329",{"$nulls":5},"integral component of membrane;synaptic vesicle",{"$nulls":3},4,4,1,"19.6","19.6","4.9","24.784",0,"16.658",542430000,35,"0.561439",1,"0.632","1.26511","tr|C9JYN0|C9JYN0_HUMAN","tr|C9JYN0|C9JYN0_HUMAN",5491,"C9JYN0","C9JYN0_HUMAN",null,null,"SYPL1"]
["25.3178","24.551","24.5548","24.399","23.4663","24.6676",{"$nulls":3},"mRNA splicing, via spliceosome;nuclear import;RNA splicing;spliceosomal complex assembly;spliceosomal snRNP assembly","RNA binding","catalytic step 2 spliceosome;cytosol;extracellular exosome;methylosome;nucleoplasm;pICln-Sm protein complex;precatalytic spliceosome;small nuclear ribonucleoprotein complex;SMN-Sm protein complex;spliceosomal complex;U1 snRNP;U12-type spliceosomal complex;U2 snRNP;U4 snRNP;U4/U6 x U5 tri-snRNP complex;U5 snRNP","Spliceosome",null,null,8,8,8,"61.9","61.9","61.9","13.527",0,"72.773",2355500000,125,"0.63991",1,"0.63026","1.41814","sp|P62316|SMD2_HUMAN;tr|K7ERG4|K7ERG4_HUMAN;tr|K7EJB5|K7EJB5_HUMAN","sp|P62316|SMD2_HUMAN;tr|K7ERG4|K7ERG4_HUMAN",1975,"P62316","SMD2_HUMAN","Small nuclear ribonucleoprotein Sm D2","m-D2","SNRPD2"]
["23.3147","22.3408","22.7249","22.5962","21.6418","22.2595",{"$nulls":3},"actin cytoskeleton organization;actin filament branching;actin filament bundle assembly;cell migration;cellular response to platelet-derived growth factor stimulus;endothelial cell chemotaxis;negative regulation of Arp2/3 complex-mediated actin nucleation;negative regulation of smooth muscle cell chemotaxis;positive regulation of lamellipodium morphogenesis;protein localization to cell leading edge;regulation of Arp2/3 complex-mediated actin nucleation;ruffle organization;wound healing","actin filament binding;Arp2/3 complex binding;cadherin binding;identical protein binding","actin filament;cell leading edge;cell periphery;cytoplasm;cytosol;extracellular exosome;focal adhesion;lamellipodium;perinuclear region of cytoplasm;plasma membrane;stress fiber",{"$nulls":3},16,16,15,"36.2","36.2","34.8","54.234",0,"179.38",1151500000,78,"0.72168",1,"0.627656","1.57753","sp|Q9BR76|COR1B_HUMAN;tr|A0A087WW53|A0A087WW53_HUMAN;tr|F5H390|F5H390_HUMAN;tr|F5H0D2|F5H0D2_HUMAN","sp|Q9BR76|COR1B_HUMAN",4156,"Q9BR76","COR1B_HUMAN","Coronin-1B",null,"CORO1B"]
["23.6196","21.1197","22.1533","22.7968","20.5874","21.6292",{"$nulls":3},"astrocyte cell migration;cellular calcium ion homeostasis;cellular protein metabolic process;chondroitin sulfate catabolic process;ganglioside catabolic process;glycosphingolipid metabolic process;hyaluronan catabolic process;keratan sulfate catabolic process;lipid storage;locomotory behavior;lysosome organization;male courtship behavior;myelination;neuromuscular process controlling balance;neutrophil degranulation;oligosaccharide catabolic process;oogenesis;penetration of zona pellucida;phospholipid biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;regulation of cell shape;sensory perception of sound;skeletal system development","acetylglucosaminyltransferase activity;beta-N-acetylhexosaminidase activity;N-acetyl-beta-D-galactosaminidase activity;protein heterodimerization activity;protein homodimerization activity","acrosomal vesicle;azurophil granule;azurophil granule lumen;extracellular exosome;extracellular region;lysosomal lumen;membrane","Amino sugar and nucleotide sugar metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - ganglio series;Glycosphingolipid biosynthesis - globo and isoglobo series;Lysosome;Metabolic pathways;Other glycan degradation",null,null,15,15,15,"32.2","32.2","32.2","63.111",0,"80.842",1337300000,73,"0.258022",1,"0.626418","0.648433","sp|P07686|HEXB_HUMAN;tr|Q5URX0|Q5URX0_HUMAN;tr|H0YA83|H0YA83_HUMAN;tr|H0Y9B6|H0Y9B6_HUMAN;tr|D6REQ8|D6REQ8_HUMAN;tr|H0Y9M3|H0Y9M3_HUMAN","sp|P07686|HEXB_HUMAN;tr|Q5URX0|Q5URX0_HUMAN",939,"P07686","HEXB_HUMAN","Beta-hexosaminidase subunit beta",null,"HEXB"]
["18.5078","18.0304","16.8883","16.2755","17.5318","17.742",{"$nulls":3},"mRNA processing","metal ion binding;RNA binding","cytoplasm;nuclear speck",{"$nulls":3},7,6,6,8,"6.9","6.9","118.72",0,"13.001",71406000,10,"0.398891",1,"0.625753","0.942889","sp|Q9P2N5|RBM27_HUMAN;tr|U3KPZ7|U3KPZ7_HUMAN","sp|Q9P2N5|RBM27_HUMAN;tr|U3KPZ7|U3KPZ7_HUMAN",4937,"Q9P2N5","RBM27_HUMAN","RNA-binding protein 27",null,"RBM27"]
["23.3742","20.4291","18.7785","21.7241","20.0042","18.9774",{"$nulls":3},"cell division;cytoskeleton-dependent intracellular transport;microtubule-based process","GTP binding;GTPase activity;structural constituent of cytoskeleton;structural molecule activity","cytoplasm;microtubule;microtubule cytoskeleton;nucleus;vesicle","Apoptosis;Gap junction;Pathogenic Escherichia coli infection;Phagosome;Tight junction",null,null,29,3,3,"66.4","13.4","13.4","49.895",0,"146.07",455950000,30,"0.148851",1,"0.625413","0.39967","sp|Q9BQE3|TBA1C_HUMAN;tr|F5H5D3|F5H5D3_HUMAN;tr|F8VVB9|F8VVB9_HUMAN;tr|F8VRZ4|F8VRZ4_HUMAN;tr|F8VS66|F8VS66_HUMAN;tr|F8VWV9|F8VWV9_HUMAN;tr|F8VX09|F8VX09_HUMAN;sp|A6NHL2|TBAL3_HUMAN;tr|C9K0S6|C9K0S6_HUMAN;tr|F8VRK0|F8VRK0_HUMAN;sp|Q9H853|TBA4B_HUMAN;tr|F8VXZ7|F8VXZ7_HUMAN;tr|F8W0F6|F8W0F6_HUMAN","sp|Q9BQE3|TBA1C_HUMAN;tr|F5H5D3|F5H5D3_HUMAN",4146,"Q9BQE3","TBA1C_HUMAN","Tubulin alpha-1C chain",null,"TUBA1C"]
["26.4872","25.1974","26.5223","26.0039","24.7397","25.5951",{"$nulls":3},"aging;antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;chaperone-mediated protein folding;clathrin-dependent endocytosis;interleukin-12-mediated signaling pathway;protein folding;protein folding in endoplasmic reticulum;protein secretion;synaptic vesicle endocytosis","apolipoprotein binding;calcium ion binding;carbohydrate binding;ionotropic glutamate receptor binding;RNA binding;unfolded protein binding","axon;dendrite cytoplasm;dendritic spine;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;ER-mitochondrion membrane contact site;extracellular exosome;extracellular matrix;integral component of lumenal side of endoplasmic reticulum membrane;melanosome;membrane;myelin sheath;neuronal cell body;protein complex;ribosome;rough endoplasmic reticulum;smooth endoplasmic reticulum","Antigen processing and presentation;Human T-cell leukemia virus 1 infection;Phagosome;Protein processing in endoplasmic reticulum;Thyroid hormone synthesis",null,null,29,29,29,48,48,48,"67.567",0,"323.31",18459000000,377,"0.470454",1,"0.622757","1.08614","sp|P27824|CALX_HUMAN;tr|H0Y9Q7|H0Y9Q7_HUMAN;tr|D6RGY2|D6RGY2_HUMAN;tr|D6RB85|D6RB85_HUMAN;tr|D6RDP7|D6RDP7_HUMAN;tr|D6RAU8|D6RAU8_HUMAN;tr|D6RFL1|D6RFL1_HUMAN;tr|H0Y9H1|H0Y9H1_HUMAN;tr|D6RAQ8|D6RAQ8_HUMAN;tr|D6RHJ3|D6RHJ3_HUMAN;tr|D6RD16|D6RD16_HUMAN","sp|P27824|CALX_HUMAN",1331,"P27824","CALX_HUMAN","Calnexin",null,"CANX"]
["21.9043","18.0315","20.945","21.9433","16.1391","20.9322",{"$nulls":3},"apoptotic process;cellular response to oxidative stress;nucleobase-containing compound metabolic process","bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity;GTP binding","mitochondrial matrix","Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,8,8,8,68,68,68,"16.829",0,"36.921",145520000,12,"0.104955",1,"0.622047","0.29128","sp|P50583|AP4A_HUMAN","sp|P50583|AP4A_HUMAN",1715,"P50583","AP4A_HUMAN","Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]",null,"NUDT2"]
["26.8125","25.5927","26.5053","26.035","25.0007","26.0152",{"$nulls":3},"heme biosynthetic process;protoporphyrinogen IX biosynthetic process;response to arsenic-containing substance;response to insecticide;response to iron ion;response to lead ion;response to methylmercury","coproporphyrinogen oxidase activity;protein homodimerization activity;structural constituent of eye lens","cytosol;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrion","Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,22,22,22,"56.6","56.6","56.6","50.151",0,"323.31",16616000000,325,"0.54747",1,"0.619879","1.23778","sp|P36551|HEM6_HUMAN;tr|H0YA22|H0YA22_HUMAN;tr|D6RER6|D6RER6_HUMAN","sp|P36551|HEM6_HUMAN",1484,"P36551","HEM6_HUMAN","Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial","oprogen oxidase;oproporphyrinogenase;OX","CPOX"]
["22.5025","21.0725","22.2589","21.877","20.3035","21.795",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;negative regulation of protein catabolic process;protein complex assembly;RNA splicing;RNA splicing, via transesterification reactions","protein complex binding;RNA binding","catalytic step 2 spliceosome;nucleolus;nucleoplasm;nucleus;small nuclear ribonucleoprotein complex;spliceosomal complex;U12-type spliceosomal complex","Spliceosome",null,null,28,28,28,"29.4","29.4","29.4","135.58",0,"203.32",2546000000,222,"0.385969",1,"0.61942","0.916677","sp|Q15393|SF3B3_HUMAN;tr|I3L4G7|I3L4G7_HUMAN;tr|J3QRB2|J3QRB2_HUMAN;tr|J3QL37|J3QL37_HUMAN;tr|H3BMB0|H3BMB0_HUMAN;tr|J3QKV4|J3QKV4_HUMAN","sp|Q15393|SF3B3_HUMAN",2595,"Q15393","SF3B3_HUMAN","Splicing factor 3B subunit 3",null,"SF3B3"]
["20.0178","20.4542","21.1128","19.5436","19.1057","21.0859",{"$nulls":3},"mitochondrial proton-transporting ATP synthase complex assembly",null,"integral component of mitochondrial membrane;mitochondrial inner membrane;mitochondrion;nucleoplasm",{"$nulls":3},6,6,6,"28.1","28.1","28.1","28.969",0,"22.943",169780000,15,"0.381277",1,"0.616523","0.907127","sp|Q9BUB7|TMM70_HUMAN;tr|D4PHA6|D4PHA6_HUMAN","sp|Q9BUB7|TMM70_HUMAN",4221,"Q9BUB7","TMM70_HUMAN","Transmembrane protein 70, mitochondrial",null,"TMEM70"]
["26.3851","25.8012","25.708","24.7711","25.6331","25.6448",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;endoplasmic reticulum;membrane","Ribosome",null,null,6,6,6,"35.1","35.1","35.1","16.561",0,"64.883",18369000000,245,"0.791996",1,"0.615073","1.71529","sp|P46776|RL27A_HUMAN;tr|E9PJD9|E9PJD9_HUMAN;tr|E9PLL6|E9PLL6_HUMAN;tr|E9PLX7|E9PLX7_HUMAN","sp|P46776|RL27A_HUMAN;tr|E9PJD9|E9PJD9_HUMAN;tr|E9PLL6|E9PLL6_HUMAN",1596,"P46776","RL27A_HUMAN","60S ribosomal protein L27a",null,"RPL27A"]
["17.2132","16.3124",1,1,"15.8485","15.8331",{"$nulls":9},3,3,3,"15.4","15.4","15.4","25.874","0.0004231","4.6387",16165000,2,"0.0286051",1,"0.614673","0.0851194","tr|K7ERA3|K7ERA3_HUMAN;sp|Q92791|SC65_HUMAN","tr|K7ERA3|K7ERA3_HUMAN;sp|Q92791|SC65_HUMAN",3714,"K7ERA3","K7ERA3_HUMAN",null,null,"P3H4"]
["22.4586","20.9494","21.843","21.6872","20.313","21.4114",{"$nulls":3},"cellular amino acid metabolic process;cellular response to drug;dihydrobiopterin metabolic process;liver development;L-phenylalanine catabolic process;response to aluminum ion;response to glucagon;response to lead ion;tetrahydrobiopterin biosynthetic process","6,7-dihydropteridine reductase activity;electron transfer activity;NADH binding;NADPH binding;protein homodimerization activity","cytoplasm;cytosol;extracellular exosome;mitochondrion;neuron projection","Folate biosynthesis;Metabolic pathways",null,null,8,8,8,"43.9","43.9","43.9","25.789",0,"54.38",411970000,29,"0.432535",1,"0.613153","1.0106","sp|P09417|DHPR_HUMAN;tr|B7Z415|B7Z415_HUMAN;tr|D6RGG7|D6RGG7_HUMAN;tr|H0Y8F7|H0Y8F7_HUMAN;tr|D6RHJ7|D6RHJ7_HUMAN","sp|P09417|DHPR_HUMAN;tr|B7Z415|B7Z415_HUMAN;tr|D6RGG7|D6RGG7_HUMAN",987,"P09417","DHPR_HUMAN","Dihydropteridine reductase",null,"QDPR"]
["19.9515","18.39","18.7104","19.1908","17.904","18.1228",{"$nulls":3},"microtubule bundle formation;mitotic cell cycle;positive regulation of microtubule polymerization;protein transport into plasma membrane raft;sister chromatid cohesion","identical protein binding;metal ion binding;microtubule binding;microtubule plus-end binding;protein homodimerization activity;tubulin binding;zinc ion binding","centrosome;cytoplasmic microtubule;cytoplasmic vesicle membrane;cytosol;endosome;intermediate filament;kinetochore;microtubule;microtubule cytoskeleton;microtubule plus-end;nuclear envelope;ruffle","mTOR signaling pathway",null,null,19,19,2,"17.5","17.5","1.3","162.24",0,"52.48",598650000,48,"0.420165",1,"0.611451","0.985791","sp|P30622|CLIP1_HUMAN;tr|F5H0N7|F5H0N7_HUMAN;tr|F5H6A0|F5H6A0_HUMAN;tr|F6VGP8|F6VGP8_HUMAN;tr|F5H1T5|F5H1T5_HUMAN;tr|F5H367|F5H367_HUMAN;tr|F5H270|F5H270_HUMAN","sp|P30622|CLIP1_HUMAN;tr|F5H0N7|F5H0N7_HUMAN",1391,"P30622","CLIP1_HUMAN","CAP-Gly domain-containing linker protein 1",null,"CLIP1"]
["18.387","19.0276","18.8728","18.178","18.9389","17.3429",{"$nulls":3},"hyaluronan catabolic process;regulation of G2/M transition of mitotic cell cycle","hyaluronic acid binding","cell surface;cytosol;membrane;plasma membrane","ECM-receptor interaction",null,null,21,21,20,34,34,33,"84.099",0,"137.75",738790000,54,"0.538008",1,"0.609204","1.21925","sp|O75330|HMMR_HUMAN;tr|E5RIH2|E5RIH2_HUMAN;tr|E5RI30|E5RI30_HUMAN","sp|O75330|HMMR_HUMAN",567,"O75330","HMMR_HUMAN","Hyaluronan mediated motility receptor",null,"HMMR"]
["17.8174","16.6695","15.7277","17.2261","15.3448","15.8224",{"$nulls":3},"DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;interferon-gamma-mediated signaling pathway;maintenance of protein location;negative regulation of cellular component movement;negative regulation of DNA binding;negative regulation of DNA binding transcription factor activity;negative regulation of endothelial cell migration;negative regulation of protein export from nucleus;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of viral transcription;positive regulation of DNA binding transcription factor activity;positive regulation of transcription, DNA-templated;regulation of angiogenesis;regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of Fas signaling pathway;response to cytokine;response to interferon-gamma;response to retinoic acid;response to type I interferon;retinoic acid receptor signaling pathway;telomere maintenance;transcription, DNA-templated;type I interferon signaling pathway;viral process","chromo shadow domain binding;DNA binding;identical protein binding;kinase binding;protein domain specific binding;protein homodimerization activity;transcription coactivator activity;transcription corepressor activity;transcription factor binding","cytoplasm;nuclear body;nuclear chromosome, telomeric region;nuclear periphery;nucleolus;nucleoplasm;nucleus;PML body","Herpes simplex virus 1 infection;Viral carcinogenesis",null,null,5,4,4,"7.8","6.9","6.9","100.42",0,"18.413",34237000,4,"0.297942",1,"0.607104","0.734154","sp|P23497|SP100_HUMAN;tr|E9PHV6|E9PHV6_HUMAN;tr|C9JBL0|C9JBL0_HUMAN;tr|H7C4B4|H7C4B4_HUMAN;tr|H7BYP4|H7BYP4_HUMAN;tr|U5Y3L1|U5Y3L1_HUMAN;sp|Q9H930|SP14L_HUMAN","sp|P23497|SP100_HUMAN;tr|E9PHV6|E9PHV6_HUMAN",1266,"P23497","SP100_HUMAN","Nuclear autoantigen Sp-100",null,"SP100"]
["20.1197","19.4976","20.6749","19.4949","20.1127","18.8662",{"$nulls":3},"cobalamin biosynthetic process;cobalamin metabolic process","ATP binding;cob(I)yrinic acid a,c-diamide adenosyltransferase activity;cobalamin binding","mitochondrial matrix","Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,6,6,6,36,36,36,"27.388",0,"15.533",138970000,15,"0.540552",1,"0.606115","1.22423","sp|Q96EY8|MMAB_HUMAN;tr|F5H4Z7|F5H4Z7_HUMAN;tr|S4R3P5|S4R3P5_HUMAN;tr|A0A087X114|A0A087X114_HUMAN;tr|S4R3Z1|S4R3Z1_HUMAN;tr|F5H079|F5H079_HUMAN","sp|Q96EY8|MMAB_HUMAN;tr|F5H4Z7|F5H4Z7_HUMAN;tr|S4R3P5|S4R3P5_HUMAN",3871,"Q96EY8","MMAB_HUMAN","Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial",null,"MMAB"]
["21.4511","21.3077","20.9618","21.3382","20.86","19.7107",{"$nulls":3},"antigen processing and presentation;endosome organization;neutrophil degranulation;plasma membrane to endosome transport;protein transport;regulation of endocytosis","GDP binding;GTP binding;GTPase activity;GTP-dependent protein binding","anchored component of synaptic vesicle membrane;early endosome;early endosome membrane;endocytic vesicle;endosome;extracellular exosome;intracellular;intracellular membrane-bounded organelle;melanosome;membrane;plasma membrane;secretory granule membrane","Amoebiasis;Endocytosis;Phagosome;Ras signaling pathway;Tuberculosis;Vasopressin-regulated water reabsorption",null,null,7,4,4,"42.3","27.4","27.4","23.707",0,"12.485",233430000,18,"0.526899",1,"0.603914","1.19746","sp|P61020|RAB5B_HUMAN;tr|F8VUA5|F8VUA5_HUMAN;tr|F8VVZ0|F8VVZ0_HUMAN;tr|F8WCY6|F8WCY6_HUMAN;tr|F8WD79|F8WD79_HUMAN;tr|F8VPW9|F8VPW9_HUMAN;tr|F8VWZ7|F8VWZ7_HUMAN","sp|P61020|RAB5B_HUMAN;tr|F8VUA5|F8VUA5_HUMAN",1911,"P61020","RAB5B_HUMAN","Ras-related protein Rab-5B",null,"RAB5B"]
["20.4319","16.7534","19.3315","17.6173","17.1646","19.9263",{"$nulls":3},"cellular response to DNA damage stimulus;mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;regulation of gene expression;RNA export from nucleus;RNA secondary structure unwinding;termination of RNA polymerase II transcription","ATP binding;ATPase activity;ATP-dependent RNA helicase activity;identical protein binding;RNA binding","cytoplasm;membrane;nuclear speck;nucleolus;nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},14,4,4,"33.7","14.3","14.3","49.129",0,"18.039",121980000,14,"0.163732",1,"0.602873","0.435139","sp|O00148|DX39A_HUMAN;tr|K7EQN7|K7EQN7_HUMAN;tr|K7EN69|K7EN69_HUMAN;tr|K7EPJ3|K7EPJ3_HUMAN;tr|K7ENP6|K7ENP6_HUMAN;tr|K7EL56|K7EL56_HUMAN;tr|K7EIL8|K7EIL8_HUMAN;tr|A0A0D9SEM9|A0A0D9SEM9_HUMAN;tr|F6SXL5|F6SXL5_HUMAN","sp|O00148|DX39A_HUMAN;tr|K7EQN7|K7EQN7_HUMAN",202,"O00148","DX39A_HUMAN","ATP-dependent RNA helicase DDX39A",null,"DDX39A"]
["22.9927","21.2159","21.7635","21.8954","20.8856","21.3867",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;retrograde vesicle-mediated transport, Golgi to ER;toxin transport","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi membrane;transport vesicle",{"$nulls":3},29,29,29,"46.8","46.8","46.8","102.49",0,"139.59",1940000000,117,"0.427773",1,"0.601458","1.00106","sp|P35606|COPB2_HUMAN;tr|H0Y938|H0Y938_HUMAN;tr|H0YAC7|H0YAC7_HUMAN;tr|D6R997|D6R997_HUMAN;tr|D6RBZ7|D6RBZ7_HUMAN;tr|D6RCL6|D6RCL6_HUMAN;tr|D6RBG7|D6RBG7_HUMAN;tr|D6RBT6|D6RBT6_HUMAN","sp|P35606|COPB2_HUMAN",1466,"P35606","COPB2_HUMAN","Coatomer subunit beta'",null,"COPB2"]
["22.6366","21.2871","22.0587","21.3035","20.9598","21.9181",{"$nulls":3},"cardiovascular system development;cell differentiation;cell redox homeostasis;negative regulation of protein ubiquitination;negative regulation of Wnt signaling pathway;Wnt signaling pathway","protein-disulfide reductase activity;thioredoxin-disulfide reductase activity","cytoplasm;cytosol;nucleus",{"$nulls":3},12,12,12,"37.2","37.2","37.2","48.392",0,"130.14",767370000,67,"0.552725",1,"0.600342","1.24807","sp|Q6DKJ4|NXN_HUMAN;tr|A0A0G2JQK5|A0A0G2JQK5_HUMAN;tr|I3L4V6|I3L4V6_HUMAN;tr|A0A0C4DGI2|A0A0C4DGI2_HUMAN","sp|Q6DKJ4|NXN_HUMAN",2946,"Q6DKJ4","NXN_HUMAN","Nucleoredoxin",null,"NXN"]
["25.8985","24.2296","24.8708","24.9835","23.5457","24.6733",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;aggresome assembly;ATP metabolic process;autophagosome maturation;autophagy;cellular response to DNA damage stimulus;DNA repair;double-strand break repair;endoplasmic reticulum stress-induced pre-emptive quality control;endoplasmic reticulum unfolded protein response;endosome to lysosome transport via multivesicular body sorting pathway;ER to Golgi vesicle-mediated transport;ERAD pathway;ER-associated misfolded protein catabolic process;error-free translesion synthesis;establishment of protein localization;flavin adenine dinucleotide catabolic process;macroautophagy;NADH metabolic process;neutrophil degranulation;positive regulation of ATP biosynthetic process;positive regulation of Lys63-specific deubiquitinase activity;positive regulation of mitochondrial membrane potential;positive regulation of oxidative phosphorylation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein catabolic process;positive regulation of protein complex assembly;positive regulation of protein K63-linked deubiquitination;proteasomal protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein folding;protein hexamerization;protein homooligomerization;protein methylation;protein N-linked glycosylation via asparagine;protein ubiquitination;regulation of aerobic respiration;regulation of apoptotic process;retrograde protein transport, ER to cytosol;translesion synthesis;transmembrane transport;ubiquitin-dependent ERAD pathway;viral genome replication","ADP binding;ATP binding;ATPase activity;BAT3 complex binding;deubiquitinase activator activity;identical protein binding;K48-linked polyubiquitin modification-dependent protein binding;lipid binding;MHC class I protein binding;polyubiquitin modification-dependent protein binding;protein domain specific binding;protein phosphatase binding;RNA binding;ubiquitin protein ligase binding;ubiquitin-like protein ligase binding;ubiquitin-specific protease binding","ATPase complex;azurophil granule lumen;cytoplasm;cytosol;Derlin-1 retrotranslocation complex;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular membrane-bounded organelle;lipid droplet;myelin sheath;nucleoplasm;nucleus;perinuclear region of cytoplasm;proteasome complex;protein complex;secretory granule lumen;site of double-strand break;VCP-NPL4-UFD1 AAA ATPase complex;VCP-NSFL1C complex","Legionellosis;Protein processing in endoplasmic reticulum",null,null,60,60,60,"80.5","80.5","80.5","89.321",0,"323.31",12588000000,460,"0.385769",1,"0.598803","0.916271","sp|P55072|TERA_HUMAN;tr|C9IZA5|C9IZA5_HUMAN;tr|C9JUP7|C9JUP7_HUMAN","sp|P55072|TERA_HUMAN",1836,"P55072","TERA_HUMAN","Transitional endoplasmic reticulum ATPase","ER ATPase","VCP"]
["22.2558","22.2753","22.2","21.2911","21.4657","22.1838",{"$nulls":5},"integral component of membrane",{"$nulls":3},16,16,16,"60.1","60.1","60.1","32.182",0,"166.6",1580400000,114,"1.02224",1,"0.596841","2.17752","tr|I3L1P8|I3L1P8_HUMAN;sp|Q02978|M2OM_HUMAN","tr|I3L1P8|I3L1P8_HUMAN;sp|Q02978|M2OM_HUMAN",2168,"I3L1P8","I3L1P8_HUMAN",null,null,"SLC25A11"]
["22.2222","20.176","21.074","21.4484","19.2338","21.0038",{"$nulls":3},"mRNA processing;regulation of transcription, DNA-templated;RNA processing;RNA splicing;transcription, DNA-templated","RNA binding","microtubule cytoskeleton;microtubule organizing center;nuclear speck;nucleoplasm;protein complex",{"$nulls":3},14,14,14,"39.6","39.6","39.6","59.379",0,"124.51",1319800000,132,"0.26439",1,"0.59536","0.66226","sp|Q14498|RBM39_HUMAN;tr|G3XAC6|G3XAC6_HUMAN;tr|H0Y4X3|H0Y4X3_HUMAN;tr|Q5QP23|Q5QP23_HUMAN;tr|Q5QP22|Q5QP22_HUMAN;tr|F8WF24|F8WF24_HUMAN;tr|F2Z3E6|F2Z3E6_HUMAN;tr|F2Z2Z5|F2Z2Z5_HUMAN;tr|A0A087X122|A0A087X122_HUMAN;tr|F8WF73|F8WF73_HUMAN;tr|A8MYG5|A8MYG5_HUMAN;tr|G3V546|G3V546_HUMAN;tr|G3V5Z6|G3V5Z6_HUMAN;tr|H0YJJ3|H0YJJ3_HUMAN;tr|G3XAP0|G3XAP0_HUMAN;sp|Q86U06|RBM23_HUMAN","sp|Q14498|RBM39_HUMAN;tr|G3XAC6|G3XAC6_HUMAN;tr|H0Y4X3|H0Y4X3_HUMAN",2476,"Q14498","RBM39_HUMAN","RNA-binding protein 39",null,"RBM39"]
["20.586","19.9347","20.6391","19.7886","19.4037","20.1864",{"$nulls":3},"fatty acid biosynthetic process;fatty acid metabolic process;long-chain fatty-acyl-CoA biosynthetic process;malonate catabolic process","acid-thiol ligase activity;ATP binding;malonyl-CoA synthetase activity;very long-chain fatty acid-CoA ligase activity","mitochondrial matrix;mitochondrion","Fatty acid biosynthesis;Fatty acid metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,15,15,15,"31.9","31.9","31.9","64.129",0,"68.451",374060000,44,"0.863141",1,"0.593715","1.85594","sp|Q4G176|ACSF3_HUMAN;tr|F5H5A1|F5H5A1_HUMAN;tr|F5H755|F5H755_HUMAN;tr|F5H362|F5H362_HUMAN;tr|F5H2G6|F5H2G6_HUMAN;tr|H0YGC7|H0YGC7_HUMAN;tr|F5H3B2|F5H3B2_HUMAN;tr|F5GX20|F5GX20_HUMAN;tr|H0YH37|H0YH37_HUMAN;tr|H0YGJ0|H0YGJ0_HUMAN","sp|Q4G176|ACSF3_HUMAN;tr|F5H5A1|F5H5A1_HUMAN;tr|F5H755|F5H755_HUMAN;tr|F5H362|F5H362_HUMAN",2756,"Q4G176","ACSF3_HUMAN","Acyl-CoA synthetase family member 3, mitochondrial",null,"ACSF3"]
["18.7524","17.2892","17.6762","17.3785","16.9448","17.6142",{"$nulls":3},"fatty acid transport;lipid metabolic process;long-chain fatty acid import;long-chain fatty acid metabolic process;long-chain fatty acid transport;medium-chain fatty acid transport;response to nutrient;skin development;transport;very long-chain fatty acid catabolic process","fatty acid transmembrane transporter activity;long-chain fatty acid-CoA ligase activity;nucleotide binding;very long-chain fatty acid-CoA ligase activity","brush border membrane;endoplasmic reticulum membrane;integral component of membrane;membrane;microvillus;plasma membrane","Fat digestion and absorption;Insulin resistance;PPAR signaling pathway",null,null,7,7,7,"14.3","14.3","14.3","72.063",0,"15.417",130260000,10,"0.547289",1,"0.593499","1.23743","sp|Q6P1M0|S27A4_HUMAN","sp|Q6P1M0|S27A4_HUMAN",2998,"Q6P1M0","S27A4_HUMAN","Long-chain fatty acid transport protein 4","ATP-4;atty acid transport protein 4","SLC27A4"]
["21.6825","20.2927","20.3592","20.8404","19.6015","20.1146",{"$nulls":4},"oxidoreductase activity",{"$nulls":4},9,9,9,"19.4","19.4","19.4","67.152",0,"32.132",271770000,19,"0.43992",1,"0.592583","1.02537","tr|F5H4B6|F5H4B6_HUMAN;sp|Q8IZ83|A16A1_HUMAN;tr|M0QY06|M0QY06_HUMAN","tr|F5H4B6|F5H4B6_HUMAN;sp|Q8IZ83|A16A1_HUMAN",3353,"F5H4B6","F5H4B6_HUMAN",null,null,"ALDH16A1"]
["23.4684","22.281","22.8504","22.9004","21.6475","22.2806",{"$nulls":3},"malate metabolic process;pyruvate metabolic process;regulation of NADP metabolic process","electron transfer activity;malate dehydrogenase (decarboxylating) (NAD+) activity;malate dehydrogenase (decarboxylating) (NADP+) activity;malic enzyme activity;metal ion binding;NAD binding;oxaloacetate decarboxylase activity","mitochondrial matrix;mitochondrion","Carbon metabolism;Pyruvate metabolism",null,null,21,21,21,"52.7","52.7","52.7","65.443",0,"281.19",1991600000,98,"0.520363",1,"0.590398","1.18462","sp|P23368|MAOM_HUMAN;tr|Q6TCH8|Q6TCH8_HUMAN;tr|E9PMB9|E9PMB9_HUMAN;sp|Q16798|MAON_HUMAN","sp|P23368|MAOM_HUMAN",1260,"P23368","MAOM_HUMAN","NAD-dependent malic enzyme, mitochondrial","AD-ME","ME2"]
["22.7947","20.9361","21.634","21.3433","20.9792","21.2796",{"$nulls":3},"cell division;circadian regulation of gene expression;entrainment of circadian clock by photoperiod;G2/M transition of mitotic cell cycle;glycogen metabolic process;protein dephosphorylation;regulation of cell adhesion;regulation of circadian rhythm","metal ion binding;myosin phosphatase activity;myosin-light-chain-phosphatase activity;phosphatase activity;protein kinase binding","cytosol;extracellular exosome;focal adhesion;nucleolus;nucleoplasm;nucleus;PTW/PP1 phosphatase complex","Adrenergic signaling in cardiomyocytes;Alcoholism;Amphetamine addiction;cAMP signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Dopaminergic synapse;Focal adhesion;Herpes simplex virus 1 infection;Hippo signaling pathway;Inflammatory mediator regulation of TRP channels;Insulin resistance;Insulin signaling pathway;Long-term potentiation;mRNA surveillance pathway;Oocyte meiosis;Oxytocin signaling pathway;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Vascular smooth muscle contraction",null,null,14,6,6,"61.2","34.3","34.3","37.186",0,"55.857",591470000,26,"0.458063",1,"0.587598","1.06154","sp|P62140|PP1B_HUMAN;tr|C9J9S3|C9J9S3_HUMAN;tr|C9JP48|C9JP48_HUMAN;tr|E7ETD8|E7ETD8_HUMAN","sp|P62140|PP1B_HUMAN",1955,"P62140","PP1B_HUMAN","Serine/threonine-protein phosphatase PP1-beta catalytic subunit","P-1B;PP1CD","PPP1CB"]
["20.5691","19.4352","19.7853","20.1074","18.4394","19.4871",{"$nulls":3},"activation of adenylate cyclase activity;adenylate cyclase-activating adrenergic receptor signaling pathway;adenylate cyclase-activating dopamine receptor signaling pathway;adenylate cyclase-activating G-protein coupled receptor signaling pathway;bone development;cellular response to catecholamine stimulus;cellular response to glucagon stimulus;cellular response to prostaglandin E stimulus;cognition;developmental growth;G-protein coupled receptor signaling pathway;hair follicle placode formation;intracellular transport;platelet aggregation;positive regulation of cAMP biosynthetic process;positive regulation of cAMP-mediated signaling;positive regulation of GTPase activity;regulation of insulin secretion;renal water homeostasis;sensory perception of smell","G-protein beta/gamma-subunit complex binding;GTP binding;GTPase activity;metal ion binding;signal transducer activity","cytoplasm;cytosol;extracellular exosome;heterotrimeric G-protein complex;intrinsic component of membrane;membrane;plasma membrane;trans-Golgi network membrane","Adrenergic signaling in cardiomyocytes;Alcoholism;Aldosterone synthesis and secretion;Amoebiasis;Amphetamine addiction;Bile secretion;Calcium signaling pathway;cAMP signaling pathway;Chagas disease (American trypanosomiasis);Circadian entrainment;Cocaine addiction;Cortisol synthesis and secretion;Cushing syndrome;Dilated cardiomyopathy (DCM);Dopaminergic synapse;Endocrine and other factor-regulated calcium reabsorption;Endocrine resistance;Estrogen signaling pathway;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Inflammatory mediator regulation of TRP channels;Insulin secretion;Long-term depression;Melanogenesis;Morphine addiction;Ovarian steroidogenesis;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;Phospholipase D signaling pathway;Platelet activation;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Salivary secretion;Serotonergic synapse;Thermogenesis;Thyroid hormone synthesis;Vascular smooth muscle contraction;Vasopressin-regulated water reabsorption;Vibrio cholerae infection",null,null,9,8,8,"28.9","26.1","26.1","45.664",0,"24.075",223450000,26,"0.422379",1,"0.585243","0.990239","sp|P63092|GNAS2_HUMAN;sp|Q5JWF2|GNAS1_HUMAN;tr|S4R3E3|S4R3E3_HUMAN;tr|A0A0A0MR13|A0A0A0MR13_HUMAN;tr|Q5JWE9|Q5JWE9_HUMAN;tr|H0Y7F4|H0Y7F4_HUMAN;tr|S4R3V9|S4R3V9_HUMAN","sp|P63092|GNAS2_HUMAN;sp|Q5JWF2|GNAS1_HUMAN",2020,"P63092","GNAS2_HUMAN","Guanine nucleotide-binding protein G(s) subunit alpha isoforms short",null,"GNAS"]
["17.7724","16.3178","16.2265","16.7398","16.1381","15.6885",{"$nulls":3},"7-methylguanosine mRNA capping;apoptotic process;DNA repair;DNA topological change;embryonic organ development;global genome nucleotide-excision repair;hair cell differentiation;nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;positive regulation of apoptotic process;positive regulation of transcription from RNA polymerase II promoter;protein localization;protein phosphorylation;regulation of mitotic cell cycle phase transition;response to hypoxia;response to oxidative stress;response to UV;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair;UV protection;viral process","3'-5' DNA helicase activity;ATP binding;ATPase activity;ATP-dependent DNA helicase activity;damaged DNA binding;DNA binding;helicase activity;protein C-terminus binding;protein N-terminus binding;transcription factor binding","core TFIIH complex;holo TFIIH complex;nucleoplasm;nucleus;transcription factor TFIID complex","Basal transcription factors;Nucleotide excision repair",null,null,22,22,22,38,38,38,"89.277",0,"92.176",561230000,81,"0.42499",1,"0.583439","0.99548","sp|P19447|ERCC3_HUMAN;tr|H7C309|H7C309_HUMAN","sp|P19447|ERCC3_HUMAN",1194,"P19447","ERCC3_HUMAN","General transcription and DNA repair factor IIH helicase subunit XPB","FIIH subunit XPB","ERCC3"]
["18.97","17.6091","18.3113","17.7009","17.476","17.9687",{"$nulls":3},"mitochondrial fission;peroxisome fission","GTP binding;GTPase activity","cytosol;intracellular membrane-bounded organelle",{"$nulls":3},25,1,1,"53.1","2.9","2.9","79.621",0,"96.346",124140000,11,"0.626282",1,"0.581591","1.39159","tr|G8JLD5|G8JLD5_HUMAN","tr|G8JLD5|G8JLD5_HUMAN",5556,"G8JLD5","G8JLD5_HUMAN",null,null,"DNM1L"]
["22.0761","22.0968","21.7869","21.8922","20.8891","21.4364",{"$nulls":3},"mRNA splicing, via spliceosome","snRNA stem-loop binding;snRNP binding;U1 snRNA binding","catalytic step 2 spliceosome;fibrillar center;nuclear speck;nucleoplasm;spliceosomal complex;U1 snRNP;U2 snRNP","Spliceosome",null,null,8,6,6,"46.7",40,40,"25.486",0,"25.424",462250000,19,"0.881833",1,"0.580695","1.89316","sp|P08579|RU2B_HUMAN","sp|P08579|RU2B_HUMAN",967,"P08579","RU2B_HUMAN","U2 small nuclear ribonucleoprotein B''","2 snRNP B''","SNRPB2"]
["19.164","18.2679","19.572","18.5669","17.1867","19.5124",{"$nulls":3},"mRNA 3'-end processing;mRNA cleavage;mRNA polyadenylation;mRNA splicing, via spliceosome;termination of RNA polymerase II transcription","mRNA binding;RNA binding","nucleoplasm;nucleus","mRNA surveillance pathway",null,null,6,6,6,"12.3","12.3","12.3","82.921",0,"29.623",205620000,19,"0.303161",1,"0.579308","0.745206","sp|Q12996|CSTF3_HUMAN;tr|H0YE74|H0YE74_HUMAN;tr|E9PJ06|E9PJ06_HUMAN;tr|E9PLP8|E9PLP8_HUMAN","sp|Q12996|CSTF3_HUMAN",2292,"Q12996","CSTF3_HUMAN","Cleavage stimulation factor subunit 3",null,"CSTF3"]
["23.4586",1,"19.8799","23.3373","18.2681",1,{"$nulls":9},2,2,2,"48.4","48.4","48.4","7.0801",0,"23.73",88352000,8,"0.0198135",1,"0.577706","0.0595069","tr|H7C4M9|H7C4M9_HUMAN;tr|C9JZG9|C9JZG9_HUMAN;tr|C9JZY6|C9JZY6_HUMAN;sp|P62256|UBE2H_HUMAN","tr|H7C4M9|H7C4M9_HUMAN;tr|C9JZG9|C9JZG9_HUMAN;tr|C9JZY6|C9JZY6_HUMAN;sp|P62256|UBE2H_HUMAN",1963,"H7C4M9","H7C4M9_HUMAN",null,null,"UBE2H"]
["22.9145","21.6868","22.5939","22.2837","21.0024","22.1908",{"$nulls":3},"protein import into mitochondrial matrix;protein targeting to mitochondrion","ATP binding;chaperone binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},17,17,17,"44.9","44.9","44.9","51.355",0,"124.71",1550500000,98,"0.445556",1,"0.572796","1.03663","sp|O43615|TIM44_HUMAN;tr|M0QXU7|M0QXU7_HUMAN;tr|M0R301|M0R301_HUMAN;tr|M0QXM9|M0QXM9_HUMAN;tr|M0R124|M0R124_HUMAN","sp|O43615|TIM44_HUMAN;tr|M0QXU7|M0QXU7_HUMAN",433,"O43615","TIM44_HUMAN","Mitochondrial import inner membrane translocase subunit TIM44",null,"TIMM44"]
["24.957","22.1132","23.5063","23.6538","21.9874","23.2177",{"$nulls":3},"camera-type eye development;cellular protein metabolic process;in utero embryonic development;post-translational protein modification","calcium ion binding","endoplasmic reticulum;endoplasmic reticulum lumen",{"$nulls":3},16,16,16,"57.7","57.7","57.7","38.89",0,"323.31",1909900000,87,"0.234096",1,"0.572491","0.595913","sp|Q15293|RCN1_HUMAN;tr|E9PP27|E9PP27_HUMAN","sp|Q15293|RCN1_HUMAN",2580,"Q15293","RCN1_HUMAN","Reticulocalbin-1",null,"RCN1"]
["21.4823","19.9898","20.9308","20.5789","19.5245","20.5888",{"$nulls":3},"actin filament-based movement;actomyosin structure organization;mitochondrion morphogenesis;neuronal action potential;regulation of cell shape;sensory perception of sound;skeletal muscle contraction;skeletal muscle tissue development;vocalization behavior","actin filament binding;actin-dependent ATPase activity;ATP binding;ATPase activity;calmodulin binding;microfilament motor activity","actomyosin;axon;brush border;cytosol;extracellular exosome;growth cone;membrane;myelin sheath;myosin II complex;myosin II filament;stress fiber","Regulation of actin cytoskeleton;Tight junction",null,null,59,49,29,"38.2","34.3","20.9","227.87",0,"323.31",2227300000,179,"0.435612",1,"0.57023","1.01676","sp|Q7Z406|MYH14_HUMAN;tr|A0A0C4DFM8|A0A0C4DFM8_HUMAN;tr|A1L2Z2|A1L2Z2_HUMAN","sp|Q7Z406|MYH14_HUMAN",3160,"Q7Z406","MYH14_HUMAN","Myosin-14",null,"MYH14"]
["20.1138","16.885","17.2442","18.1712","16.7345","17.6313",{"$nulls":3},"activation of GTPase activity;axonogenesis;establishment of neuroblast polarity;interkinetic nuclear migration;microtubule cytoskeleton organization;neuron projection development;positive regulation of peptidyl-serine phosphorylation;positive regulation of vascular associated smooth muscle cell migration;regulation of neurogenesis;small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity;Rac GTPase binding","axon;basal part of cell;focal adhesion;growth cone;intracellular;neuron projection",{"$nulls":3},14,14,12,"8.7","8.7","7.8","242.56",0,"58.329",335960000,28,"0.198105",1,"0.568658","0.514982","sp|Q96N67|DOCK7_HUMAN;tr|H0Y7L2|H0Y7L2_HUMAN;tr|A0A0C4DGY6|A0A0C4DGY6_HUMAN","sp|Q96N67|DOCK7_HUMAN;tr|H0Y7L2|H0Y7L2_HUMAN",3981,"Q96N67","DOCK7_HUMAN","Dedicator of cytokinesis protein 7",null,"DOCK7"]
["19.6864","19.6193","19.8017","19.168","18.7551","19.4838",{"$nulls":3},"enzyme-directed rRNA pseudouridine synthesis","pseudouridine synthase activity;RNA binding",{"$nulls":4},6,6,6,16,16,16,"61.311",0,"22.241",191030000,19,"1.22383",1,"0.566853","2.6051","sp|Q8IZ73|RUSD2_HUMAN;tr|A0A087WXE2|A0A087WXE2_HUMAN","sp|Q8IZ73|RUSD2_HUMAN;tr|A0A087WXE2|A0A087WXE2_HUMAN",3351,"Q8IZ73","RUSD2_HUMAN","RNA pseudouridylate synthase domain-containing protein 2",null,"RPUSD2"]
["19.7179","18.446","18.9969","19.5032","17.9184","18.0394",{"$nulls":3},"cellular homeostasis;mitochondrial outer membrane permeabilization;mitochondrion transport along microtubule;regulation of small GTPase mediated signal transduction","calcium ion binding;GTP binding;GTPase activity","cytosol;extracellular exosome;integral component of mitochondrial outer membrane;membrane;plasma membrane","Mitophagy - animal",null,null,7,7,6,"17.8","17.8",16,"68.117",0,"32.938",142710000,25,"0.378514",1,"0.566587","0.901497","sp|Q8IXI1|MIRO2_HUMAN;tr|H3BST5|H3BST5_HUMAN;tr|I3L2C6|I3L2C6_HUMAN;tr|H3BUX4|H3BUX4_HUMAN;tr|H3BMP9|H3BMP9_HUMAN;tr|H3BVI5|H3BVI5_HUMAN;tr|H3BU27|H3BU27_HUMAN","sp|Q8IXI1|MIRO2_HUMAN;tr|H3BST5|H3BST5_HUMAN;tr|I3L2C6|I3L2C6_HUMAN",3319,"Q8IXI1","MIRO2_HUMAN","Mitochondrial Rho GTPase 2","IRO-2;Miro-2","RHOT2"]
["24.1984","22.5498","23.399","23.1674","22.129","23.1574",{"$nulls":3},"anaerobic respiration;mitochondrial electron transport, succinate to ubiquinone;nervous system development;oxidation-reduction process;respiratory electron transport chain;succinate metabolic process;tricarboxylic acid cycle","electron transfer activity;flavin adenine dinucleotide binding;succinate dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);mitochondrion;myelin sheath;nucleolus","Alzheimer disease;Carbon metabolism;Citrate cycle (TCA cycle);Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,24,24,24,"56.9","56.9","56.9","72.691",0,"323.31",2604200000,134,"0.407682",1,"0.564436","0.960654","sp|P31040|SDHA_HUMAN;tr|D6RFM5|D6RFM5_HUMAN;tr|A0A087X1I3|A0A087X1I3_HUMAN;tr|H0Y8X1|H0Y8X1_HUMAN","sp|P31040|SDHA_HUMAN;tr|D6RFM5|D6RFM5_HUMAN;tr|A0A087X1I3|A0A087X1I3_HUMAN",1397,"P31040","SDHA_HUMAN","Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",null,"SDHA"]
["20.8484","19.0185","17.1372","19.7499","18.4315","17.1381",{"$nulls":3},"histidyl-tRNA aminoacylation;translation;tRNA aminoacylation for protein translation","ATP binding;histidine-tRNA ligase activity;protein homodimerization activity;RNA binding","mitochondrial matrix;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,13,6,6,"26.7","12.8","12.8","56.888",0,"22.971",188210000,13,"0.160986",1,"0.561546","0.428637","sp|P49590|SYHM_HUMAN;tr|B4DQ67|B4DQ67_HUMAN;tr|D6RJE6|D6RJE6_HUMAN;tr|D6RB22|D6RB22_HUMAN","sp|P49590|SYHM_HUMAN;tr|B4DQ67|B4DQ67_HUMAN",1667,"P49590","SYHM_HUMAN","Probable histidine--tRNA ligase, mitochondrial",null,"HARS2"]
["22.1461","21.9852","20.9235","21.0642","20.9448","21.3675",{"$nulls":3},"dopamine catabolic process;hydrogen peroxide biosynthetic process;negative regulation of serotonin secretion;neurotransmitter catabolic process;positive regulation of dopamine metabolic process;response to aluminum ion;response to corticosterone;response to drug;response to ethanol;response to lipopolysaccharide;response to selenium ion;response to toxic substance;substantia nigra development","electron transfer activity;flavin adenine dinucleotide binding;primary amine oxidase activity;protein homodimerization activity","extracellular exosome;integral component of membrane;mitochondrial envelope;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion","Alcoholism;Amphetamine addiction;Arginine and proline metabolism;Cocaine addiction;Dopaminergic synapse;Drug metabolism - cytochrome P450;Glycine, serine and threonine metabolism;Histidine metabolism;Metabolic pathways;Phenylalanine metabolism;Serotonergic synapse;Tryptophan metabolism;Tyrosine metabolism",null,null,10,10,9,"26.3","26.3","24.2","58.762",0,"74.733",868040000,51,"0.623331",1,"0.559397","1.38585","sp|P27338|AOFB_HUMAN","sp|P27338|AOFB_HUMAN",1317,"P27338","AOFB_HUMAN","Amine oxidase [flavin-containing] B",null,"MAOB"]
["20.3209","18.7951","20.1337","18.5128","18.7712","20.2892",{"$nulls":5},"Golgi apparatus;integral component of membrane",{"$nulls":3},3,3,3,"11.5","11.5","11.5","44.772",0,"58.319",186260000,22,"0.311123",1,"0.558844","0.762","sp|Q96K37|S35E1_HUMAN;tr|H7C1I0|H7C1I0_HUMAN","sp|Q96K37|S35E1_HUMAN;tr|H7C1I0|H7C1I0_HUMAN",3952,"Q96K37","S35E1_HUMAN","Solute carrier family 35 member E1",null,"SLC35E1"]
["27.2219","25.7319","27.0441","26.711","25.1449","26.4716",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of peptide antigen via MHC class I;ATF6-mediated unfolded protein response;cardiac muscle cell differentiation;cellular calcium ion homeostasis;cellular response to lithium ion;cellular senescence;chaperone-mediated protein folding;cortical actin cytoskeleton organization;glucocorticoid receptor signaling pathway;negative regulation of cell cycle arrest;negative regulation of intracellular steroid hormone receptor signaling pathway;negative regulation of neuron differentiation;negative regulation of retinoic acid receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of translation;negative regulation of trophoblast cell migration;peptide antigen assembly with MHC class I protein complex;positive regulation of cell cycle;positive regulation of cell proliferation;positive regulation of dendritic cell chemotaxis;positive regulation of DNA replication;positive regulation of endothelial cell migration;positive regulation of gene expression;positive regulation of NIK/NF-kappaB signaling;positive regulation of phagocytosis;positive regulation of substrate adhesion-dependent cell spreading;protein export from nucleus;protein folding;protein folding in endoplasmic reticulum;protein localization to nucleus;protein maturation by protein folding;protein stabilization;receptor-mediated endocytosis;regulation of apoptotic process;regulation of meiotic nuclear division;regulation of transcription, DNA-templated;response to drug;response to estradiol;response to testosterone;sequestering of calcium ion;spermatogenesis;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane","androgen receptor binding;calcium ion binding;carbohydrate binding;chaperone binding;complement component C1q binding;DNA binding;hormone binding;integrin binding;iron ion binding;mRNA binding;peptide binding;protein binding involved in protein folding;RNA binding;ubiquitin protein ligase binding;unfolded protein binding;zinc ion binding","acrosomal vesicle;cell surface;cytoplasm;cytosol;endocytic vesicle lumen;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment membrane;external side of plasma membrane;extracellular exosome;extracellular region;extracellular space;focal adhesion;Golgi apparatus;integral component of lumenal side of endoplasmic reticulum membrane;intracellular;membrane;MHC class I peptide loading complex;nucleus;perinuclear region of cytoplasm;phagocytic vesicle membrane;polysome;proteinaceous extracellular matrix;sarcoplasmic reticulum lumen;smooth endoplasmic reticulum","Antigen processing and presentation;Chagas disease (American trypanosomiasis);Epstein-Barr virus infection;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human T-cell leukemia virus 1 infection;Phagosome;Protein processing in endoplasmic reticulum",null,null,23,23,23,"78.2","78.2","78.2","48.141",0,"323.31",17046000000,519,"0.340194",1,"0.556773","0.822721","sp|P27797|CALR_HUMAN;tr|K7EJB9|K7EJB9_HUMAN;tr|K7EL50|K7EL50_HUMAN","sp|P27797|CALR_HUMAN;tr|K7EJB9|K7EJB9_HUMAN",1329,"P27797","CALR_HUMAN","Calreticulin",null,"CALR"]
["22.3032","21.3771","21.6352","21.7287","21.1772","20.7425",{"$nulls":3},"axonogenesis;interleukin-12-mediated signaling pathway;lipid metabolic process;phospholipid transport;visual perception","phosphatidylcholine binding;phosphatidylcholine transporter activity;phosphatidylglycerol binding;phosphatidylinositol binding;phosphatidylinositol transporter activity","cytosol;extracellular exosome;myelin sheath",{"$nulls":3},10,8,8,"39.3",33,33,"31.806",0,"160.99",559100000,39,"0.630536",1,"0.555674","1.39988","sp|Q00169|PIPNA_HUMAN;tr|F5GWE5|F5GWE5_HUMAN;tr|I3L459|I3L459_HUMAN;tr|I3L4H1|I3L4H1_HUMAN;tr|I3L4C0|I3L4C0_HUMAN;tr|I3L2X8|I3L2X8_HUMAN;tr|I3L471|I3L471_HUMAN;tr|I3L4U7|I3L4U7_HUMAN;tr|I3L3W1|I3L3W1_HUMAN;tr|I3NI10|I3NI10_HUMAN","sp|Q00169|PIPNA_HUMAN;tr|F5GWE5|F5GWE5_HUMAN;tr|I3L459|I3L459_HUMAN;tr|I3L4H1|I3L4H1_HUMAN;tr|I3L4C0|I3L4C0_HUMAN",2114,"Q00169","PIPNA_HUMAN","Phosphatidylinositol transfer protein alpha isoform","I-TP-alpha;tdIns transfer protein alpha;tdInsTP alpha","PITPNA"]
["20.0601","18.4232","19.8642","19.3217","18.6302","18.7481",{"$nulls":3},"glucose homeostasis;intracellular protein transport;positive regulation of protein modification process;regulation of glucose import",null,"cytoplasmic side of plasma membrane;cytosol;endomembrane system;endoplasmic reticulum-Golgi intermediate compartment membrane;extrinsic component of membrane;intracellular membrane-bounded organelle;nucleoplasm;perinuclear region of cytoplasm;plasma membrane;vesicle membrane","Transcriptional misregulation in cancer",null,null,8,8,8,"27.5","27.5","27.5","60.182",0,"26.59",206890000,24,"0.418879",1,"0.549171","0.983204","sp|Q9BZE9|ASPC1_HUMAN;tr|J3KRY8|J3KRY8_HUMAN;tr|J3QR12|J3QR12_HUMAN;tr|J3QL04|J3QL04_HUMAN;tr|J3KRF7|J3KRF7_HUMAN","sp|Q9BZE9|ASPC1_HUMAN;tr|J3KRY8|J3KRY8_HUMAN;tr|J3QR12|J3QR12_HUMAN;tr|J3QL04|J3QL04_HUMAN",4329,"Q9BZE9","ASPC1_HUMAN","Tether containing UBX domain for GLUT4",null,"ASPSCR1"]
["18.8452","18.2479","18.852","18.3678","17.9829","17.9472",{"$nulls":9},2,2,2,"10.4","10.4","10.4","24.322",0,"5.8716",89964000,3,"1.06947",1,"0.549063","2.27539","tr|B7ZBC9|B7ZBC9_HUMAN;tr|B7ZBC8|B7ZBC8_HUMAN;sp|O75449|KTNA1_HUMAN","tr|B7ZBC9|B7ZBC9_HUMAN;tr|B7ZBC8|B7ZBC8_HUMAN;sp|O75449|KTNA1_HUMAN",593,"B7ZBC9","B7ZBC9_HUMAN",null,null,"KATNA1"]
["21.547","20.2651","20.2868","20.8368","19.666","19.9526",{"$nulls":3},"androgen metabolic process;estrogen biosynthetic process;fatty acid biosynthetic process;fatty-acyl-CoA biosynthetic process;oxidation-reduction process;protein heterotetramerization","3-hydroxyacyl-CoA dehydrogenase activity;3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity;estradiol 17-beta-dehydrogenase activity;NADH binding;testosterone dehydrogenase (NAD+) activity","mitochondrial envelope;mitochondrial matrix;plasma membrane","Fatty acid biosynthesis;Fatty acid metabolism;Metabolic pathways;Steroid hormone biosynthesis",null,null,5,5,5,"26.4","26.4","26.4","26.973",0,"18.758",231170000,14,"0.424277",1,"0.547817","0.994049","sp|Q92506|DHB8_HUMAN","sp|Q92506|DHB8_HUMAN",3666,"Q92506","DHB8_HUMAN","Estradiol 17-beta-dehydrogenase 8",null,"HSD17B8"]
["22.0538","20.1335","21.0412","20.7541","20.315","20.5212",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;antigen processing and presentation, exogenous lipid antigen via MHC class Ib;endosome to melanosome transport;eye pigment biosynthetic process;intracellular protein transport;melanosome organization;neurotransmitter receptor transport, postsynaptic endosome to lysosome;positive regulation of NK T cell differentiation;protein localization to membrane;regulation of sequestering of zinc ion;synaptic vesicle budding from endosome;synaptic vesicle membrane organization","transporter activity","AP-3 adaptor complex;axon cytoplasm;endosome membrane;Golgi apparatus;Golgi membrane;lysosomal membrane;membrane;plasma membrane;presynaptic endosome;terminal bouton","Lysosome",null,null,38,38,38,"42.2","42.2","42.2","130.16",0,"323.31",3868600000,261,"0.407237",1,"0.546058","0.959756","sp|O14617|AP3D1_HUMAN;tr|A0A087WYN6|A0A087WYN6_HUMAN;tr|K7ELX8|K7ELX8_HUMAN;tr|K7ERW8|K7ERW8_HUMAN","sp|O14617|AP3D1_HUMAN",275,"O14617","AP3D1_HUMAN","AP-3 complex subunit delta-1",null,"AP3D1"]
["20.5476",1,"20.4777","19.39",1,"20.0036",{"$nulls":3},"mitochondrion organization",null,"integral component of mitochondrial inner membrane;integral component of plasma membrane;mitochondrion",{"$nulls":3},2,2,2,"12.5","12.5","12.5","21.541",0,"5.4973",64977000,9,"0.0201072",1,"0.543927","0.0603701","sp|P17152|TMM11_HUMAN","sp|P17152|TMM11_HUMAN",1149,"P17152","TMM11_HUMAN","Transmembrane protein 11, mitochondrial",null,"TMEM11"]
["26.8644","26.2187","26.2366","25.1985","25.8545","26.6355",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;endoplasmic reticulum;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus","Ribosome",null,null,13,13,13,"56.2","56.2","56.2","24.205",0,"323.31",33783000000,539,"0.510747",1,"0.543766","1.16572","sp|P62241|RS8_HUMAN;tr|Q5JR95|Q5JR95_HUMAN","sp|P62241|RS8_HUMAN;tr|Q5JR95|Q5JR95_HUMAN",1959,"P62241","RS8_HUMAN","40S ribosomal protein S8",null,"RPS8"]
["23.2404","22.0356","22.5912","22.7474","21.319","22.1731",{"$nulls":3},"membrane protein proteolysis;membrane protein proteolysis involved in retrograde protein transport, ER to cytosol;protein homotetramerization","aspartic endopeptidase activity, intramembrane cleaving;peptidase activity;protein homodimerization activity;ubiquitin protein ligase binding","cell surface;Derlin-1 retrotranslocation complex;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi-associated vesicle membrane;integral component of cytoplasmic side of endoplasmic reticulum membrane;integral component of lumenal side of endoplasmic reticulum membrane;lysosomal membrane;membrane;plasma membrane;rough endoplasmic reticulum",{"$nulls":3},7,7,7,"20.7","20.7","20.7","41.488",0,"83.244",878970000,34,"0.428076",1,"0.542555","1.00167","sp|Q8TCT9|HM13_HUMAN;tr|A0A075B6F6|A0A075B6F6_HUMAN;tr|A0A0C4DGU3|A0A0C4DGU3_HUMAN","sp|Q8TCT9|HM13_HUMAN;tr|A0A075B6F6|A0A075B6F6_HUMAN",3555,"Q8TCT9","HM13_HUMAN","Minor histocompatibility antigen H13",null,"HM13"]
["18.3379","17.0304","17.4225","18.1323","16.1056","16.9298",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;cell-cell signaling;female pregnancy;membrane organization;peptide catabolic process;protein catabolic process;protein polyubiquitination;proteolysis;regulation of blood pressure;signal transduction;SMAD protein signal transduction","aminopeptidase activity;metalloaminopeptidase activity;metallopeptidase activity;peptide binding;zinc ion binding","cytoplasmic vesicle membrane;cytosol;early endosome lumen;extracellular region;integral component of plasma membrane;intracellular;lysosomal membrane;membrane;perinuclear region of cytoplasm;plasma membrane","Renin-angiotensin system",null,null,8,8,8,"9.5","9.5","9.5","117.35",0,"22.104",109300000,18,"0.313938",1,"0.541014","0.767921","sp|Q9UIQ6|LCAP_HUMAN","sp|Q9UIQ6|LCAP_HUMAN",5054,"Q9UIQ6","LCAP_HUMAN","Leucyl-cystinyl aminopeptidase","ystinyl aminopeptidase","LNPEP"]
["23.9774","23.6926","23.8118","23.0254","23.3711","23.4671",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;maturation of SSU-rRNA;mRNA splicing, via spliceosome;RNA splicing;tRNA processing","RNA binding","cytosol;extracellular exosome;nucleolus;nucleoplasm;P-body;small nuclear ribonucleoprotein complex;small nucleolar ribonucleoprotein complex;spliceosomal complex;U4/U6 x U5 tri-snRNP complex;U6 snRNP","RNA degradation;Spliceosome",null,null,5,5,5,55,55,55,"9.1275",0,"15.312",624430000,22,"1.57406",1,"0.539418","3.42469","sp|P62312|LSM6_HUMAN","sp|P62312|LSM6_HUMAN",1973,"P62312","LSM6_HUMAN","U6 snRNA-associated Sm-like protein LSm6",null,"LSM6"]
["24.6948","22.4774","23.5211","24.1132","21.7612","23.2009",{"$nulls":3},"camera-type eye development;gluconeogenesis;glycerol catabolic process;glycerophosphate shuttle;multicellular organism growth","calcium ion binding;glycerol-3-phosphate dehydrogenase activity;sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity","glycerol-3-phosphate dehydrogenase complex;mitochondrial inner membrane","Glycerophospholipid metabolism",null,null,37,37,37,"66.3","66.3","66.3","80.852",0,"323.31",4601800000,193,"0.224812",1,"0.53933","0.575271","sp|P43304|GPDM_HUMAN;tr|F5GYK7|F5GYK7_HUMAN;tr|E9PDK4|E9PDK4_HUMAN;tr|E7EM56|E7EM56_HUMAN","sp|P43304|GPDM_HUMAN",1570,"P43304","GPDM_HUMAN","Glycerol-3-phosphate dehydrogenase, mitochondrial","PDH-M;PD-M","GPD2"]
["23.1669","22.1933","22.2193","22.4441","21.6205","21.9049",{"$nulls":3},"glutathione metabolic process;hydrogen sulfide metabolic process;sulfide oxidation, using sulfide:quinone oxidoreductase","iron ion binding;sulfur dioxygenase activity","cytoplasm;mitochondrial matrix;mitochondrion;nucleoplasm","Metabolic pathways;Sulfur metabolism",null,null,6,6,6,"29.5","29.5","29.5","27.873",0,"31.129",724770000,27,"0.598698",1,"0.536688","1.33784","sp|O95571|ETHE1_HUMAN;tr|M0QXB5|M0QXB5_HUMAN;tr|M0QY80|M0QY80_HUMAN;tr|M0QX80|M0QX80_HUMAN","sp|O95571|ETHE1_HUMAN;tr|M0QXB5|M0QXB5_HUMAN",769,"O95571","ETHE1_HUMAN","Persulfide dioxygenase ETHE1, mitochondrial",null,"ETHE1"]
["20.4506","20.0469","19.9538","19.9641","19.1717","19.7081",{"$nulls":3},"cellular protein localization;positive regulation of transcription from RNA polymerase II promoter",null,"integral component of mitochondrial outer membrane;nucleus",{"$nulls":3},10,10,10,38,38,38,"42.5",0,"47.64",297050000,47,"0.895954",1,"0.535782","1.92137","sp|Q9UH62|ARMX3_HUMAN;tr|H3BM63|H3BM63_HUMAN;tr|H3BV87|H3BV87_HUMAN","sp|Q9UH62|ARMX3_HUMAN",5011,"Q9UH62","ARMX3_HUMAN","Armadillo repeat-containing X-linked protein 3",null,"ARMCX3"]
["22.8686","21.6491","21.2364","21.4699","21.1552","21.5219",{"$nulls":3},"activation of MAPK activity;Bergmann glial cell differentiation;cell cycle arrest;cell motility;cellular senescence;cerebellar cortex formation;chemotaxis;epithelial cell proliferation involved in lung morphogenesis;ERK1 and ERK2 cascade;face development;heart development;keratinocyte differentiation;labyrinthine layer development;MAPK cascade;movement of cell or subcellular component;negative regulation of cell proliferation;negative regulation of gene expression;neuron differentiation;peptidyl-threonine phosphorylation;placenta blood vessel development;positive regulation of axonogenesis;positive regulation of ERK1 and ERK2 cascade;positive regulation of gene expression;positive regulation of production of miRNAs involved in gene silencing by miRNA;positive regulation of protein serine/threonine kinase activity;positive regulation of transcription, DNA-templated;protein phosphorylation;proteolysis in other organism;regulation of apoptotic process;regulation of axon regeneration;regulation of early endosome to late endosome transport;regulation of Golgi inheritance;regulation of mitotic cell cycle;regulation of stress-activated MAPK cascade;signal transduction;thymus development;thyroid gland development;trachea formation","ATP binding;MAP kinase kinase activity;protein C-terminus binding;protein kinase activity;protein N-terminus binding;protein serine/threonine kinase activator activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity;signal transducer, downstream of receptor, with protein tyrosine phosphatase activity","cytosol;early endosome;endoplasmic reticulum;extracellular exosome;focal adhesion;Golgi apparatus;late endosome;microtubule organizing center;mitochondrion;nucleus;plasma membrane","Acute myeloid leukemia;Alcoholism;Apelin signaling pathway;Apoptosis;Autophagy - animal;B cell receptor signaling pathway;Bladder cancer;Breast cancer;cAMP signaling pathway;Cellular senescence;Central carbon metabolism in cancer;cGMP-PKG signaling pathway;Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;Cushing syndrome;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Focal adhesion;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;MicroRNAs in cancer;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-small cell lung cancer;Oocyte meiosis;Osteoclast differentiation;Oxytocin signaling pathway;Pancreatic cancer;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prion diseases;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Serotonergic synapse;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid cancer;Thyroid hormone signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Yersinia infection",null,null,16,10,10,42,"27.7","27.7","43.439",0,"201.98",648640000,28,"0.459646",1,"0.535738","1.06469","sp|Q02750|MP2K1_HUMAN;tr|H3BRW9|H3BRW9_HUMAN","sp|Q02750|MP2K1_HUMAN",2161,"Q02750","MP2K1_HUMAN","Dual specificity mitogen-activated protein kinase kinase 1","AP kinase kinase 1;APKK 1;KK1","MAP2K1"]
["24.0108","22.6373","22.7016","23.1745","22.1993","22.3804",{"$nulls":3},"citrate metabolic process;generation of precursor metabolites and energy;isocitrate metabolic process;liver development;response to isolation stress;tricarboxylic acid cycle","3 iron, 4 sulfur cluster binding;4 iron, 4 sulfur cluster binding;aconitate hydratase activity;iron ion binding","mitochondrial matrix;mitochondrion;myelin sheath","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Metabolic pathways",null,null,28,28,28,"47.1","47.1","47.1","85.424",0,"323.31",3021500000,163,"0.421102",1,"0.531839","0.987673","sp|Q99798|ACON_HUMAN;tr|A2A274|A2A274_HUMAN","sp|Q99798|ACON_HUMAN;tr|A2A274|A2A274_HUMAN",4109,"Q99798","ACON_HUMAN","Aconitate hydratase, mitochondrial","conitase","ACO2"]
["18.9696","18.3811","18.6955","18.7904","16.9879","18.6749",{"$nulls":3},"protein folding in endoplasmic reticulum",null,"ER membrane protein complex;integral component of membrane",{"$nulls":3},3,3,1,13,13,"5.4","29.952",0,"6.5094",33032000,4,"0.36558",1,"0.531","0.875052","sp|Q9P0I2|EMC3_HUMAN;tr|S4R3U9|S4R3U9_HUMAN","sp|Q9P0I2|EMC3_HUMAN",4902,"Q9P0I2","EMC3_HUMAN","ER membrane protein complex subunit 3",null,"EMC3"]
["23.0516","18.8482","21.2933","21.9881","18.3269","21.2886",{"$nulls":4},"translation elongation factor activity",{"$nulls":4},4,4,4,"45.1","45.1","45.1","12.527",0,"49.804",190520000,14,"0.116275",1,"0.529856","0.319821","tr|B8ZZU8|B8ZZU8_HUMAN;sp|Q15370|ELOB_HUMAN;tr|I3L0M9|I3L0M9_HUMAN;tr|A0A0B4J296|A0A0B4J296_HUMAN","tr|B8ZZU8|B8ZZU8_HUMAN;sp|Q15370|ELOB_HUMAN;tr|I3L0M9|I3L0M9_HUMAN;tr|A0A0B4J296|A0A0B4J296_HUMAN",2589,"B8ZZU8","B8ZZU8_HUMAN",null,null,"ELOB"]
["21.0301","20.7097","21.4421","19.5711","20.5747","21.4519",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;cell redox homeostasis;cellular response to angiotensin;cellular response to gamma radiation;cellular response to glucose stimulus;cellular response to L-glutamine;cellular response to mechanical stimulus;cellular response to organic cyclic compound;cellular response to oxidative stress;cellular response to tumor necrosis factor;cytochrome complex assembly;hydrogen peroxide biosynthetic process;inflammatory response;innate immune response;negative regulation of glomerular filtration by angiotensin;neutrophil degranulation;oxidation-reduction process;positive regulation of cell growth;positive regulation of defense response to bacterium;positive regulation of endothelial cell proliferation;positive regulation of interleukin-6 production;positive regulation of mucus secretion;positive regulation of NAD(P)H oxidase activity;positive regulation of phagocytosis;positive regulation of reactive oxygen species biosynthetic process;positive regulation of smooth muscle cell proliferation;positive regulation of superoxide anion generation;positive regulation of toll-like receptor 2 signaling pathway;positive regulation of tumor necrosis factor production;regulation of release of sequestered calcium ion into cytosol;respiratory burst;response to activity;response to aldosterone;response to drug;response to hypoxia;response to interleukin-1;response to nutrient levels;smooth muscle hypertrophy;superoxide anion generation;superoxide metabolic process;vascular endothelial growth factor receptor signaling pathway","electron transfer activity;heme binding;metal ion binding;protein heterodimerization activity;SH3 domain binding;superoxide-generating NADPH oxidase activity","apical plasma membrane;dendrite;endoplasmic reticulum membrane;endosome;focal adhesion;Golgi apparatus;membrane;mitochondrion;NADPH oxidase complex;neuronal cell body;nucleus;perinuclear endoplasmic reticulum;phagocytic vesicle membrane;plasma membrane;secretory granule;specific granule membrane;stress fiber;tertiary granule membrane","Fluid shear stress and atherosclerosis;Leishmaniasis;Leukocyte transendothelial migration;NOD-like receptor signaling pathway;Osteoclast differentiation;Phagosome",null,null,3,3,3,"16.4","16.4","16.4","21.012",0,"10.17",246300000,10,"0.380442",1,"0.528087","0.905426","sp|P13498|CY24A_HUMAN;tr|H3BR52|H3BR52_HUMAN;tr|H3BPX1|H3BPX1_HUMAN;tr|H3BNP7|H3BNP7_HUMAN","sp|P13498|CY24A_HUMAN",1080,"P13498","CY24A_HUMAN","Cytochrome b-245 light chain",null,"CYBA"]
["23.2888","21.8454","22.6037","22.589","21.33","22.2364",{"$nulls":3},"mitochondrial calcium ion transmembrane transport;protein processing involved in protein targeting to mitochondrion;proteolysis","metalloendopeptidase activity;zinc ion binding","extracellular space;mitochondrial inner membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},18,18,18,"43.2","43.2","43.2","58.252",0,"168.95",2106100000,96,"0.397885",1,"0.527522","0.940854","sp|Q10713|MPPA_HUMAN;tr|Q5SXN9|Q5SXN9_HUMAN","sp|Q10713|MPPA_HUMAN",2254,"Q10713","MPPA_HUMAN","Mitochondrial-processing peptidase subunit alpha",null,"PMPCA"]
["19.107","17.4972","18.4471","17.9833","16.7686","18.7214",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosomal small subunit assembly","snoRNA binding","Pwp2p-containing subcomplex of 90S preribosome;small-subunit processome",{"$nulls":3},12,12,11,"18.4","18.4",17,"102.45",0,"103.43",641990000,69,"0.288568",1,"0.526007","0.71422","tr|A0A0B4J2E5|A0A0B4J2E5_HUMAN;sp|Q15269|PWP2_HUMAN;tr|C9J544|C9J544_HUMAN;tr|A0A0J9YX21|A0A0J9YX21_HUMAN","tr|A0A0B4J2E5|A0A0B4J2E5_HUMAN;sp|Q15269|PWP2_HUMAN",2574,"A0A0B4J2E5","A0A0B4J2E5_HUMAN",null,null,"LOC102724159"]
["22.9173","23.3719","23.4127","22.356","22.3355","23.438",{"$nulls":3},"fatty-acyl-CoA biosynthetic process;gluconeogenesis;mitochondrial citrate transport;mitochondrial transport","citrate transmembrane transporter activity;tricarboxylic acid transmembrane transporter activity","extracellular exosome;integral component of membrane;mitochondrial inner membrane;nucleus",{"$nulls":3},10,10,10,"38.3","38.3","38.3","34.012",0,"65.534",6565400000,174,"0.58929",1,"0.524158","1.3195","sp|P53007|TXTP_HUMAN;tr|B4DP62|B4DP62_HUMAN","sp|P53007|TXTP_HUMAN;tr|B4DP62|B4DP62_HUMAN",1790,"P53007","TXTP_HUMAN","Tricarboxylate transport protein, mitochondrial",null,"SLC25A1"]
["19.3255",1,"20.7395","19.4643",1,"19.0304",{"$nulls":3},"phospholipid biosynthetic process","phosphotransferase activity, for other substituted phosphate groups","integral component of membrane",{"$nulls":3},3,3,3,"13.4","13.4","13.4","45.078",0,"37.285",59052000,10,"0.019805",1,"0.523396","0.0594817","tr|A0A087WW58|A0A087WW58_HUMAN;sp|Q9C0D9|EPT1_HUMAN;tr|C9JAG1|C9JAG1_HUMAN","tr|A0A087WW58|A0A087WW58_HUMAN;sp|Q9C0D9|EPT1_HUMAN;tr|C9JAG1|C9JAG1_HUMAN",4352,"A0A087WW58","A0A087WW58_HUMAN",null,null,"SELENOI"]
["17.235","17.8532","17.3487","17.2852","16.5842","16.9998",{"$nulls":4},"protein-cysteine S-palmitoyltransferase activity","integral component of membrane",{"$nulls":3},1,1,1,"6.5","6.5","6.5","33.743",0,"5.9798",23065000,9,"0.873765",1,"0.522622","1.87708","tr|B4DRN8|B4DRN8_HUMAN;sp|Q5W0Z9|ZDH20_HUMAN","tr|B4DRN8|B4DRN8_HUMAN;sp|Q5W0Z9|ZDH20_HUMAN",2914,"B4DRN8","B4DRN8_HUMAN","Palmitoyltransferase {ECO:0000256|RuleBase:RU079119}",null,"ZDHHC20"]
["26.0044","24.8014","25.1775","24.7223","24.6487","25.053",{"$nulls":3},"autophagy;COPII vesicle coating;ER to Golgi vesicle-mediated transport;positive regulation of glycoprotein metabolic process;post-translational protein modification;protein transport;regulation of autophagosome assembly;retrograde vesicle-mediated transport, Golgi to ER;virion assembly","GTP binding;GTPase activity","cytosol;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;Golgi apparatus;Golgi membrane;mitochondrion;phagophore assembly site membrane;transport vesicle","Legionellosis",null,null,12,12,5,"70.1","70.1","31.8","22.171",0,"271.13",5602000000,144,"0.620689",1,"0.51976","1.3807","sp|Q9H0U4|RAB1B_HUMAN;tr|E9PLD0|E9PLD0_HUMAN;tr|A0A087WTI1|A0A087WTI1_HUMAN;sp|Q92928|RAB1C_HUMAN","sp|Q9H0U4|RAB1B_HUMAN;tr|E9PLD0|E9PLD0_HUMAN;tr|A0A087WTI1|A0A087WTI1_HUMAN",4400,"Q9H0U4","RAB1B_HUMAN","Ras-related protein Rab-1B",null,"RAB1B"]
["20.2795","18.0033","19.6516","19.988","16.1754","20.2163",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;activation of MAPK activity;angiogenesis;apoptotic process;cartilage condensation;cell morphogenesis;cell surface receptor signaling pathway;cellular response to ionizing radiation;cellular response to lipopolysaccharide;cellular response to lipoteichoic acid;cellular response to tumor necrosis factor;cellular response to vascular endothelial growth factor stimulus;cellular response to virus;chemotaxis;chondrocyte differentiation;DNA damage checkpoint;fatty acid oxidation;glucose metabolic process;intracellular signal transduction;lipopolysaccharide-mediated signaling pathway;movement of cell or subcellular component;myoblast differentiation involved in skeletal muscle regeneration;negative regulation of canonical Wnt signaling pathway;neutrophil degranulation;osteoclast differentiation;p38MAPK cascade;peptidyl-serine phosphorylation;placenta development;positive regulation of brown fat cell differentiation;positive regulation of cardiac muscle cell proliferation;positive regulation of cyclase activity;positive regulation of cytokine secretion involved in immune response;positive regulation of erythrocyte differentiation;positive regulation of gene expression;positive regulation of glucose import;positive regulation of interleukin-12 secretion;positive regulation of macrophage chemotaxis;positive regulation of metallopeptidase activity;positive regulation of muscle cell differentiation;positive regulation of myoblast differentiation;positive regulation of myoblast fusion;positive regulation of myotube differentiation;positive regulation of protein import into nucleus;positive regulation of reactive oxygen species metabolic process;positive regulation of transcription from RNA polymerase II promoter;Ras protein signal transduction;regulation of cytokine production involved in inflammatory response;regulation of DNA binding transcription factor activity;regulation of ossification;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;response to muramyl dipeptide;response to muscle stretch;signal transduction;signal transduction in response to DNA damage;skeletal muscle tissue development;stress-induced premature senescence;striated muscle cell differentiation;transcription, DNA-templated;transmembrane receptor protein serine/threonine kinase signaling pathway;vascular endothelial growth factor receptor signaling pathway","ATP binding;enzyme binding;MAP kinase activity;MAP kinase kinase activity;mitogen-activated protein kinase p38 binding;NFAT protein binding;protein phosphatase binding;protein serine/threonine kinase activity","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;mitochondrion;nuclear speck;nucleoplasm;nucleus;secretory granule lumen;spindle pole","Adrenergic signaling in cardiomyocytes;AGE-RAGE signaling pathway in diabetic complications;Amyotrophic lateral sclerosis (ALS);Cellular senescence;Chagas disease (American trypanosomiasis);C-type lectin receptor signaling pathway;Dopaminergic synapse;Endocrine resistance;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;FoxO signaling pathway;GnRH signaling pathway;Hepatitis B;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;IL-17 signaling pathway;Inflammatory mediator regulation of TRP channels;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Leukocyte transendothelial migration;MAPK signaling pathway;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Oocyte meiosis;Osteoclast differentiation;PD-L1 expression and PD-1 checkpoint pathway in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Relaxin signaling pathway;Retrograde endocannabinoid signaling;RIG-I-like receptor signaling pathway;Salmonella infection;Shigellosis;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thermogenesis;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;VEGF signaling pathway;Yersinia infection",null,null,10,10,10,"43.6","43.6","43.6","41.293",0,"47.248",123350000,21,"0.128888",1,"0.518229","0.351122","sp|Q16539|MK14_HUMAN;tr|B4E0K5|B4E0K5_HUMAN;tr|B5TY33|B5TY33_HUMAN;tr|E7EX54|E7EX54_HUMAN;tr|H7C4E2|H7C4E2_HUMAN","sp|Q16539|MK14_HUMAN;tr|B4E0K5|B4E0K5_HUMAN;tr|B5TY33|B5TY33_HUMAN",2670,"Q16539","MK14_HUMAN","Mitogen-activated protein kinase 14","AP kinase 14;APK 14","MAPK14"]
["20.6105","18.9751","19.8139","19.1085","18.8446","19.8933",{"$nulls":3},"regulation of actin polymerization or depolymerization;regulation of axonogenesis;regulation of lamellipodium assembly","actin binding;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity","cytoplasm;cytoskeleton;nucleus","Axon guidance;Regulation of actin cytoskeleton",null,null,9,9,9,"22.2","22.2","22.2","72.995",0,"31.535",280170000,37,"0.383745",1,"0.517701","0.912153","sp|Q8TE77|SSH3_HUMAN;tr|A0A087WWG1|A0A087WWG1_HUMAN;tr|C9JUG3|C9JUG3_HUMAN;tr|E9PIT5|E9PIT5_HUMAN","sp|Q8TE77|SSH3_HUMAN",3572,"Q8TE77","SSH3_HUMAN","Protein phosphatase Slingshot homolog 3",null,"SSH3"]
["23.153","22.1098","22.1131","22.5787","21.6356","21.6127",{"$nulls":3},"adipose tissue development;brain development;cellular ketone body metabolic process;heart development;ketone body catabolic process;ketone catabolic process;positive regulation of insulin secretion involved in cellular response to glucose stimulus;response to activity;response to drug;response to ethanol;response to hormone;response to nutrient;response to starvation","3-oxoacid CoA-transferase activity;protein homodimerization activity","mitochondrial matrix;mitochondrion;nucleoplasm","Butanoate metabolism;Metabolic pathways;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation",null,null,16,16,16,"44.2","44.2","44.2","56.157",0,"323.31",1119000000,79,"0.475532",1,"0.516303","1.09621","sp|P55809|SCOT1_HUMAN;tr|E9PDW2|E9PDW2_HUMAN;sp|Q9BYC2|SCOT2_HUMAN","sp|P55809|SCOT1_HUMAN;tr|E9PDW2|E9PDW2_HUMAN",1855,"P55809","SCOT1_HUMAN","Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial",null,"OXCT1"]
["23.2624","22.7953","23.2935","22.6483","22.1123","23.0471",{"$nulls":3},"adherens junction assembly;androgen receptor signaling pathway;anterior/posterior axis specification;beta-catenin destruction complex disassembly;beta-catenin-TCF complex assembly;bone resorption;branching involved in blood vessel morphogenesis;branching involved in ureteric bud morphogenesis;canonical Wnt signaling pathway;canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;canonical Wnt signaling pathway involved in negative regulation of apoptotic process;canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation;canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition;catenin import into nucleus;cell adhesion;cell fate specification;cell maturation;cell morphogenesis involved in differentiation;cell-cell adhesion;cell-matrix adhesion;cellular response to growth factor stimulus;cellular response to indole-3-methanol;central nervous system vasculogenesis;chemical synaptic transmission;chromatin-mediated maintenance of transcription;cranial ganglion development;cranial skeletal system development;dorsal root ganglion development;dorsal/ventral axis specification;ectoderm development;embryonic axis specification;embryonic brain development;embryonic digit morphogenesis;embryonic foregut morphogenesis;embryonic forelimb morphogenesis;embryonic heart tube development;embryonic hindlimb morphogenesis;embryonic skeletal limb joint morphogenesis;endodermal cell fate commitment;endothelial tube morphogenesis;entry of bacterium into host cell;epithelial cell differentiation involved in prostate gland development;epithelial to mesenchymal transition;epithelial tube branching involved in lung morphogenesis;fungiform papilla formation;gastrulation with mouth forming second;genitalia morphogenesis;glial cell fate determination;hair cell differentiation;hair follicle morphogenesis;hair follicle placode formation;hindbrain development;in utero embryonic development;layer formation in cerebral cortex;lens morphogenesis in camera-type eye;lung cell differentiation;lung induction;lung-associated mesenchyme development;male genitalia development;mesenchymal cell proliferation involved in lung development;metanephros morphogenesis;midbrain dopaminergic neuron differentiation;negative regulation of angiogenesis;negative regulation of apoptotic signaling pathway;negative regulation of cell death;negative regulation of cell proliferation;negative regulation of chondrocyte differentiation;negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;negative regulation of mitotic cell cycle, embryonic;negative regulation of oligodendrocyte differentiation;negative regulation of osteoclast differentiation;negative regulation of oxidative stress-induced neuron death;negative regulation of protein sumoylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;nephron tubule formation;neural plate development;neuron migration;neuron projection extension;odontogenesis of dentin-containing tooth;oocyte development;osteoclast differentiation;oviduct development;pancreas development;positive regulation of apoptotic process;positive regulation of chromatin-mediated maintenance of transcription;positive regulation of core promoter binding;positive regulation of determination of dorsal identity;positive regulation of DNA binding transcription factor activity;positive regulation of DNA-templated transcription, initiation;positive regulation of endothelial cell differentiation;positive regulation of epithelial cell proliferation involved in prostate gland development;positive regulation of epithelial to mesenchymal transition;positive regulation of fibroblast growth factor receptor signaling pathway;positive regulation of heparan sulfate proteoglycan biosynthetic process;positive regulation of histone H3-K4 methylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of MAPK cascade;positive regulation of mesenchymal cell proliferation;positive regulation of muscle cell differentiation;positive regulation of neuroblast proliferation;positive regulation of neuron apoptotic process;positive regulation of osteoblast differentiation;positive regulation of skeletal muscle tissue development;positive regulation of telomerase activity;positive regulation of telomere maintenance via telomerase;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;proteasome-mediated ubiquitin-dependent protein catabolic process;protein localization to cell surface;proximal/distal pattern formation;regulation of angiogenesis;regulation of calcium ion import;regulation of centriole-centriole cohesion;regulation of centromeric sister chromatid cohesion;regulation of euchromatin binding;regulation of fibroblast proliferation;regulation of myelination;regulation of nephron tubule epithelial cell differentiation;regulation of neurogenesis;regulation of protein localization to cell surface;regulation of secondary heart field cardioblast proliferation;regulation of smooth muscle cell proliferation;regulation of T cell proliferation;regulation of timing of anagen;renal inner medulla development;renal outer medulla development;renal vesicle formation;response to drug;response to estradiol;smooth muscle cell differentiation;stem cell population maintenance;sympathetic ganglion development;synapse organization;synaptic vesicle transport;T cell differentiation in thymus;thymus development;trachea formation;transcription, DNA-templated;Wnt signaling pathway;Wnt signaling pathway, calcium modulating pathway","alpha-catenin binding;androgen receptor binding;cadherin binding;chromatin binding;disordered domain specific binding;DNA binding transcription factor activity;enzyme binding;estrogen receptor binding;ion channel binding;I-SMAD binding;kinase binding;nuclear hormone receptor binding;protein C-terminus binding;protein heterodimerization activity;protein kinase binding;protein phosphatase binding;repressing transcription factor binding;RNA polymerase II activating transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription factor binding;signal transducer activity;SMAD binding;transcription coactivator activity;transcription factor binding;transcription regulatory region DNA binding","adherens junction;apical part of cell;basolateral plasma membrane;beta-catenin destruction complex;beta-catenin-TCF complex;beta-catenin-TCF7L2 complex;bicellular tight junction;catenin complex;cell cortex;cell junction;cell periphery;cell-cell adherens junction;cell-cell junction;centrosome;cytoplasm;cytosol;extracellular exosome;fascia adherens;flotillin complex;focal adhesion;intracellular;lamellipodium;lateral plasma membrane;membrane;microvillus membrane;nuclear euchromatin;nucleoplasm;nucleus;perinuclear region of cytoplasm;plasma membrane;protein complex;protein-DNA complex;Scrib-APC-beta-catenin complex;spindle pole;synapse;transcription factor complex;Wnt signalosome;Z disc","Adherens junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Basal cell carcinoma;Breast cancer;Colorectal cancer;Cushing syndrome;Endometrial cancer;Fluid shear stress and atherosclerosis;Focal adhesion;Gastric cancer;Hepatitis C;Hepatocellular carcinoma;Hippo signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Melanogenesis;Pathogenic Escherichia coli infection;Pathways in cancer;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Signaling pathways regulating pluripotency of stem cells;Thyroid cancer;Thyroid hormone signaling pathway;Wnt signaling pathway",null,null,27,23,23,"48.8","42.6","42.6","85.496",0,"291.39",3386200000,171,"0.749821",1,"0.514468","1.63255","sp|P35222|CTNB1_HUMAN;tr|B4DGU4|B4DGU4_HUMAN;tr|E7EMJ5|E7EMJ5_HUMAN;tr|E9PDF9|E9PDF9_HUMAN;tr|E7EV28|E7EV28_HUMAN","sp|P35222|CTNB1_HUMAN;tr|B4DGU4|B4DGU4_HUMAN",1447,"P35222","CTNB1_HUMAN","Catenin beta-1",null,"CTNNB1"]
["19.0358","18.2805","18.8076","18.5689","17.3007","18.7125",{"$nulls":3},"endocytic recycling;endocytosis;positive regulation of histamine secretion by mast cell;protein transport;vesicle organization","epidermal growth factor receptor binding;insulin receptor binding;leptin receptor binding;phosphatidylinositol binding;transferrin receptor binding","cytoplasm;cytoplasmic dynein complex;early endosome membrane;extrinsic component of membrane;membrane;plasma membrane;protein complex;SNARE complex","Endocytosis",null,null,7,7,7,"18.9","18.9","18.9","51.908",0,"53.774",132440000,19,"0.439873",1,"0.513911","1.02528","sp|O95219|SNX4_HUMAN;tr|F8W9T3|F8W9T3_HUMAN","sp|O95219|SNX4_HUMAN",725,"O95219","SNX4_HUMAN","Sorting nexin-4",null,"SNX4"]
["22.1217","20.477","21.3567","20.8984","20.2646","21.2519",{"$nulls":3},"ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;microtubule-based process;platelet degranulation;regulation of G2/M transition of mitotic cell cycle","enzyme binding;GTP binding;GTPase activity;structural constituent of cytoskeleton","cytosol;extracellular exosome;extracellular region;microtubule;microtubule cytoskeleton","Apoptosis;Gap junction;Pathogenic Escherichia coli infection;Phagosome;Tight junction",null,null,27,4,4,"61.8","12.1","12.1","49.924",0,"21.496",663130000,45,"0.389322",1,"0.513501","0.92349","sp|P68366|TBA4A_HUMAN;tr|C9JEV8|C9JEV8_HUMAN;tr|C9JDS9|C9JDS9_HUMAN;tr|C9JQ00|C9JQ00_HUMAN;tr|C9JJQ8|C9JJQ8_HUMAN;tr|C9JDL2|C9JDL2_HUMAN","sp|P68366|TBA4A_HUMAN",2045,"P68366","TBA4A_HUMAN","Tubulin alpha-4A chain",null,"TUBA4A"]
["18.9415","18.4965","19.5523","18.7796","17.4683","19.2035",{"$nulls":3},"gamma-aminobutyric acid catabolic process","succinate-semialdehyde dehydrogenase [NAD(P)+] activity","mitochondrion",{"$nulls":3},6,6,6,15,15,15,"53.867",0,"16.819",127830000,18,"0.352154",1,"0.512985","0.84745","tr|C9J8Q5|C9J8Q5_HUMAN;sp|P51649|SSDH_HUMAN","tr|C9J8Q5|C9J8Q5_HUMAN;sp|P51649|SSDH_HUMAN",1748,"C9J8Q5","C9J8Q5_HUMAN",null,null,"ALDH5A1"]
["20.0787","18.7408",1,"19.1419","18.1459",1,{"$nulls":3},"brain development;copper ion transport;generation of precursor metabolites and energy;heart development;mitochondrial respiratory chain complex IV assembly;positive regulation of cell proliferation;positive regulation of cytochrome-c oxidase activity","copper chaperone activity;copper ion binding;cuprous ion binding","cytoplasm;mitochondrial intermembrane space","Metabolic pathways;Oxidative phosphorylation;Thermogenesis",null,null,1,1,1,"25.4","25.4","25.4","6.9151","0.00041356","4.1727",18643000,6,"0.0199719",1,"0.510574","0.0599725","sp|Q14061|COX17_HUMAN;tr|C9J8T6|C9J8T6_HUMAN","sp|Q14061|COX17_HUMAN;tr|C9J8T6|C9J8T6_HUMAN",2429,"Q14061","COX17_HUMAN","Cytochrome c oxidase copper chaperone",null,"COX17"]
["21.9825","21.2286","21.6947","21.4025","20.5619","21.4128",{"$nulls":3},"long-chain fatty acid metabolic process;medium-chain fatty acid metabolic process;mitochondrial respiratory chain complex I assembly","flavin adenine dinucleotide binding;long-chain-acyl-CoA dehydrogenase activity;medium-chain-acyl-CoA dehydrogenase activity","dendrite;mitochondrial inner membrane;mitochondrial membrane;mitochondrion;nucleus",{"$nulls":3},19,19,19,"37.8","37.8","37.8","68.76",0,"141.21",997150000,68,"0.643768",1,"0.509535","1.42565","sp|Q9H845|ACAD9_HUMAN;tr|H0Y8Z9|H0Y8Z9_HUMAN;tr|D6RCD8|D6RCD8_HUMAN","sp|Q9H845|ACAD9_HUMAN;tr|H0Y8Z9|H0Y8Z9_HUMAN",4516,"Q9H845","ACAD9_HUMAN","Acyl-CoA dehydrogenase family member 9, mitochondrial","CAD-9","ACAD9"]
["16.8579","18.7939","18.6012","16.2213","18.3336","18.1718",{"$nulls":3},"activation of cysteine-type endopeptidase activity;activation of GTPase activity;intracellular protein transport;positive regulation of proteolysis;regulation of vesicle fusion;retrograde transport, endosome to Golgi","cadherin binding;GTPase activator activity;guanyl-nucleotide exchange factor activity;PDZ domain binding;Rab GTPase binding","cytosol;endomembrane system;extracellular exosome;intracellular;microvillus;plasma membrane",{"$nulls":3},8,8,8,"25.8","25.8","25.8","57.117",0,"44.059",250650000,18,"0.215849",1,"0.508782","0.555192","sp|Q9BXI6|TB10A_HUMAN;tr|B5MD46|B5MD46_HUMAN;tr|H0Y2U5|H0Y2U5_HUMAN;tr|H7C1Q1|H7C1Q1_HUMAN;tr|F8WDN6|F8WDN6_HUMAN;tr|H7C471|H7C471_HUMAN;tr|H0Y5R9|H0Y5R9_HUMAN;tr|F8WCD1|F8WCD1_HUMAN;tr|F8W9Y7|F8W9Y7_HUMAN","sp|Q9BXI6|TB10A_HUMAN;tr|B5MD46|B5MD46_HUMAN;tr|H0Y2U5|H0Y2U5_HUMAN;tr|H7C1Q1|H7C1Q1_HUMAN",4292,"Q9BXI6","TB10A_HUMAN","TBC1 domain family member 10A",null,"TBC1D10A"]
["21.7839","19.1952","20.9784","20.2374","19.5138","20.6824",{"$nulls":3},"metal ion transport","metal ion binding","cytoplasm;mitochondrion;nucleus",{"$nulls":3},6,6,6,"42.9","42.9","42.9","31.28",0,"59.158",183970000,12,"0.238989",1,"0.507987","0.606731","sp|Q9NVT9|ARMC1_HUMAN;tr|E5RJ86|E5RJ86_HUMAN","sp|Q9NVT9|ARMC1_HUMAN;tr|E5RJ86|E5RJ86_HUMAN",4774,"Q9NVT9","ARMC1_HUMAN","Armadillo repeat-containing protein 1",null,"ARMC1"]
["22.5758","21.2092","22.0912","22.0948","20.4222","21.8367",{"$nulls":3},"cell division;cellular response to heat;cellular response to interferon-alpha;intracellular transport of virus;MAPK import into nucleus;mitotic nuclear envelope disassembly;mitotic spindle assembly checkpoint;mRNA export from nucleus;mRNA export from nucleus in response to heat stress;negative regulation of RNA export from nucleus;negative regulation of transcription from RNA polymerase II promoter;negative regulation of translational initiation;nuclear pore organization;positive regulation of heterochromatin assembly;positive regulation of intracellular protein transport;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of protein export from nucleus;positive regulation of protein import into nucleus;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of mitotic sister chromatid separation;regulation of mitotic spindle assembly;response to epidermal growth factor;RNA export from nucleus;RNA import into nucleus;tRNA export from nucleus;viral process;viral transcription","chromatin binding;dynein complex binding;heat shock protein binding;mitogen-activated protein kinase binding;mRNA binding;nucleocytoplasmic transporter activity;protein homodimerization activity;RNA binding;tubulin binding","cytoplasm;cytoplasmic dynein complex;extrinsic component of membrane;host cell;kinetochore;mitotic spindle;nuclear envelope;nuclear inclusion body;nuclear membrane;nuclear periphery;nuclear pore;nuclear pore nuclear basket;nucleoplasm;nucleus","Pathways in cancer;RNA transport;Thyroid cancer",null,null,66,66,66,"34.7","34.7","34.7","267.29",0,"323.31",3636400000,262,"0.316651",1,"0.507469","0.773618","sp|P12270|TPR_HUMAN;tr|Q5SWX9|Q5SWX9_HUMAN","sp|P12270|TPR_HUMAN",1064,"P12270","TPR_HUMAN","Nucleoprotein TPR",null,"TPR"]
["22.1569","21.7321","22.2051","21.9555","20.8599","21.7613",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of gene expression;positive regulation of cell cycle G1/S phase transition;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of gene expression;positive regulation of I-kappaB phosphorylation;positive regulation of metallopeptidase activity;positive regulation of NF-kappaB transcription factor activity;positive regulation of proteasomal protein catabolic process;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein localization to endoplasmic reticulum;positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding;positive regulation of transcription from RNA polymerase II promoter;protein K69-linked ufmylation;regulation of intracellular estrogen receptor signaling pathway;response to endoplasmic reticulum stress","RNA polymerase II repressing transcription factor binding;ubiquitin-like protein ligase binding","cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;nucleolus",{"$nulls":3},11,11,11,"55.7","55.7","55.7","35.61",0,"104.62",1333500000,100,"0.614654",1,"0.505788","1.36894","sp|Q96HY6|DDRGK_HUMAN;tr|A0A0A0MRX2|A0A0A0MRX2_HUMAN","sp|Q96HY6|DDRGK_HUMAN;tr|A0A0A0MRX2|A0A0A0MRX2_HUMAN",3918,"Q96HY6","DDRGK_HUMAN","DDRGK domain-containing protein 1 {ECO:0000305}",null,"DDRGK1"]
["22.3729","22.3445","22.7181","21.4083","21.862","22.6538",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion","Ribosome",null,null,4,4,4,"35.2","35.2","35.2","15.947",0,"80.397",1817500000,89,"0.586772",1,"0.503787","1.31458","sp|Q6P1L8|RM14_HUMAN","sp|Q6P1L8|RM14_HUMAN",2997,"Q6P1L8","RM14_HUMAN","39S ribosomal protein L14, mitochondrial","14mt;RP-L14","MRPL14"]
["26.5465","24.4077","26.1651","25.4473","23.9156","26.2469",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;rRNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;focal adhesion;membrane","Ribosome",null,null,10,10,10,"40.9","40.9","40.9","28.024",0,"255.76",8809100000,120,"0.204658",1,"0.503157","0.529905","sp|P62917|RL8_HUMAN;tr|E9PKZ0|E9PKZ0_HUMAN;tr|E9PKU4|E9PKU4_HUMAN;tr|G3V1A1|G3V1A1_HUMAN;tr|E9PP36|E9PP36_HUMAN","sp|P62917|RL8_HUMAN;tr|E9PKZ0|E9PKZ0_HUMAN;tr|E9PKU4|E9PKU4_HUMAN;tr|G3V1A1|G3V1A1_HUMAN;tr|E9PP36|E9PP36_HUMAN",2011,"P62917","RL8_HUMAN","60S ribosomal protein L8",null,"RPL8"]
["22.8879","21.56","22.7737","22.4025","21.1935","22.1262",{"$nulls":3},"peptide metabolic process","aminopeptidase activity;identical protein binding;metalloaminopeptidase activity;zinc ion binding","blood microparticle;cytoplasm;cytosol;nucleus",{"$nulls":3},13,13,13,"42.5","42.5","42.5","52.428",0,"106.34",865960000,45,"0.373612",1,"0.499788","0.891491","sp|Q9ULA0|DNPEP_HUMAN;tr|E7ETB3|E7ETB3_HUMAN;tr|E7EMB6|E7EMB6_HUMAN;tr|C9JBE1|C9JBE1_HUMAN;tr|F8WAN0|F8WAN0_HUMAN;tr|B9ZVU2|B9ZVU2_HUMAN;tr|E7EPX3|E7EPX3_HUMAN;tr|C9J1E2|C9J1E2_HUMAN;tr|E5RJ35|E5RJ35_HUMAN;tr|C9JRG3|C9JRG3_HUMAN","sp|Q9ULA0|DNPEP_HUMAN;tr|E7ETB3|E7ETB3_HUMAN;tr|E7EMB6|E7EMB6_HUMAN;tr|C9JBE1|C9JBE1_HUMAN",5112,"Q9ULA0","DNPEP_HUMAN","Aspartyl aminopeptidase",null,"DNPEP"]
["22.1843","22.1799","22.0664","21.3913","21.4325","22.117",{"$nulls":3},"axonogenesis;cristae formation;mitochondrial calcium ion homeostasis;mitochondrial calcium ion transmembrane transport;mitochondrial calcium uptake;mitochondrial fusion;mitochondrial protein processing;muscle fiber development;myelination;nerve development;neuromuscular junction development;protein autoprocessing;protein processing;proteolysis;regulation of multicellular organism growth;righting reflex","ATP binding;metalloendopeptidase activity;metallopeptidase activity;unfolded protein binding;zinc ion binding","m-AAA complex;mitochondrial inner membrane;mitochondrion",{"$nulls":3},27,27,26,"40.3","40.3","39.3","88.583",0,"291.77",3854600000,259,"0.97581",1,"0.496614","2.08246","sp|Q9Y4W6|AFG32_HUMAN;tr|K7EP56|K7EP56_HUMAN;tr|B7Z651|B7Z651_HUMAN","sp|Q9Y4W6|AFG32_HUMAN",5335,"Q9Y4W6","AFG32_HUMAN","AFG3-like protein 2",null,"AFG3L2"]
["20.61","18.767","19.4496","20.4197","17.5858","19.3381",{"$nulls":3},"exocytosis","dipeptidase activity","extracellular exosome",{"$nulls":3},4,4,4,"18.1","18.1","18.1","46.596",0,"25.519",111880000,10,"0.192281",1,"0.49435","0.501643","sp|Q96FV2|SCRN2_HUMAN;tr|J3QL71|J3QL71_HUMAN;tr|J3QQM9|J3QQM9_HUMAN;tr|J3QRJ1|J3QRJ1_HUMAN;tr|J3KT79|J3KT79_HUMAN;tr|J3QR84|J3QR84_HUMAN","sp|Q96FV2|SCRN2_HUMAN;tr|J3QL71|J3QL71_HUMAN;tr|J3QQM9|J3QQM9_HUMAN;tr|J3QRJ1|J3QRJ1_HUMAN",3879,"Q96FV2","SCRN2_HUMAN","Secernin-2",null,"SCRN2"]
["17.3129","16.3659","17.8437","16.4935","16.3567","17.191",{"$nulls":3},"chemotaxis;doxorubicin transport;drug transmembrane transport;endocytosis;positive regulation of GTPase activity;regulation of GTPase activity;regulation of small GTPase mediated signal transduction;signal transduction;small GTPase mediated signal transduction;transmembrane transport","ATPase activity, coupled to movement of substances;drug transmembrane transporter activity;GTPase activator activity;Rac GTPase binding;Ral GTPase binding;transmembrane transporter activity","cytosol;membrane","Pancreatic cancer;Pathways in cancer;Ras signaling pathway",null,null,5,5,5,"11.9","11.9","11.9","76.063",0,"16.084",70532000,16,"0.41755",1,"0.493717","0.980532","sp|Q15311|RBP1_HUMAN;tr|E7ENF8|E7ENF8_HUMAN","sp|Q15311|RBP1_HUMAN",2581,"Q15311","RBP1_HUMAN","RalA-binding protein 1","alBP1","RALBP1"]
["22.7436","21.816","22.7917","22.3248","21.5579","21.9893",{"$nulls":3},"branched-chain amino acid catabolic process;fatty acid metabolic process","acyl-CoA dehydrogenase activity;flavin adenine dinucleotide binding","extracellular exosome;mitochondrial matrix;mitochondrion","Fatty acid degradation;Fatty acid metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,13,13,13,"42.1","42.1","42.1","47.485",0,"128.61",1046300000,71,"0.565413",1,"0.49311","1.27288","sp|P45954|ACDSB_HUMAN","sp|P45954|ACDSB_HUMAN",1579,"P45954","ACDSB_HUMAN","Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial","BCAD","ACADSB"]
["17.7907","17.3882","17.8582","17.247","16.9444","17.3688",{"$nulls":3},"actin cytoskeleton reorganization;calcium ion transport;calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;cellular calcium ion homeostasis;cellular manganese ion homeostasis;epidermis development;Golgi calcium ion homeostasis;Golgi calcium ion transport;ion transmembrane transport;manganese ion transport;positive regulation of I-kappaB kinase/NF-kappaB signaling","ATP binding;calcium ion binding;calcium-transporting ATPase activity;manganese ion binding;manganese-transporting ATPase activity;metal ion binding;signal transducer activity","Golgi apparatus;Golgi membrane;integral component of membrane;membrane;trans-Golgi network",{"$nulls":3},7,7,7,"12.5","12.5","12.5","100.58",0,"24.612",89885000,13,"1.19584",1,"0.492304","2.5441","sp|P98194|AT2C1_HUMAN;tr|B4E2Q0|B4E2Q0_HUMAN;tr|H0Y9V7|H0Y9V7_HUMAN;tr|H0Y9S7|H0Y9S7_HUMAN;tr|D6RGE9|D6RGE9_HUMAN;tr|D6REJ1|D6REJ1_HUMAN;tr|D6RHV9|D6RHV9_HUMAN;tr|H0Y8X9|H0Y8X9_HUMAN","sp|P98194|AT2C1_HUMAN;tr|B4E2Q0|B4E2Q0_HUMAN;tr|H0Y9V7|H0Y9V7_HUMAN",2110,"P98194","AT2C1_HUMAN","Calcium-transporting ATPase type 2C member 1","TPase 2C1","ATP2C1"]
["23.79","22.7435","23.6494","23.1764","22.3559","23.1783",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process;cellular response to aldosterone;cellular response to estradiol stimulus;cellular response to hydrogen peroxide;cellular response to nitric oxide;cellular response to oxygen-glucose deprivation;chromosome condensation;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;mitochondrial respiratory chain complex I assembly;neuron apoptotic process;neuron differentiation;positive regulation of apoptotic process;positive regulation of neuron apoptotic process;regulation of apoptotic DNA fragmentation;response to ischemia;response to L-glutamate;response to toxic substance","DNA binding;FAD binding;NAD(P)H oxidase activity;oxidoreductase activity, acting on NAD(P)H;protein dimerization activity","cytosol;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrion;nucleus;perinuclear region of cytoplasm","Apoptosis;Necroptosis",null,null,19,19,19,"43.1","43.1","43.1","66.9",0,"196.95",3023800000,129,"0.502151",1,"0.490793","1.14879","sp|O95831|AIFM1_HUMAN;tr|E9PMA0|E9PMA0_HUMAN","sp|O95831|AIFM1_HUMAN",799,"O95831","AIFM1_HUMAN","Apoptosis-inducing factor 1, mitochondrial",null,"AIFM1"]
["22.148","21.2672","21.7186","21.8666","20.6188","21.1813",{"$nulls":3},"actin filament-based movement;actomyosin structure organization;cell adhesion;mitotic cytokinesis;positive regulation of protein secretion;regulation of cell shape","actin binding;actin filament binding;actin-dependent ATPase activity;ADP binding;ATP binding;ATPase activity;calmodulin binding;microfilament motor activity;mRNA 5'-UTR binding;RNA stem-loop binding","actomyosin;cell cortex;cleavage furrow;cytoplasm;cytosol;extracellular exosome;lamellipodium;midbody;myosin complex;myosin II complex;myosin II filament;nucleus;polysome;stress fiber","Regulation of actin cytoskeleton;Tight junction",null,null,80,66,59,"46.6","38.9","36.4",229,0,"323.31",3546800000,258,"0.481484",1,"0.489057","1.10799","sp|P35580|MYH10_HUMAN;tr|E7ERA5|E7ERA5_HUMAN","sp|P35580|MYH10_HUMAN",1465,"P35580","MYH10_HUMAN","Myosin-10",null,"MYH10"]
["26.0784","24.4068","25.4307","24.9917","24.5762","24.8845",{"$nulls":3},"base-excision repair;DNA unwinding involved in DNA replication;establishment of integrated proviral latency;negative regulation of cell proliferation;negative regulation of chromatin silencing;negative regulation of transcription, DNA-templated;nuclear transport;nucleosome disassembly;oncogene-induced cell senescence;positive regulation of cellular senescence;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;protein complex assembly;regulation of transcription, DNA-templated;response to virus;senescence-associated heterochromatin focus assembly","5'-deoxyribose-5-phosphate lyase activity;AT DNA binding;chromatin binding;DNA binding;DNA binding transcription factor activity;DNA-(apurinic or apyrimidinic site) lyase activity;enhancer sequence-specific DNA binding;enzyme binding;ligand-dependent nuclear receptor transcription coactivator activity;peroxisome proliferator activated receptor binding;retinoic acid receptor binding;retinoid X receptor binding;transcription factor binding;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding","cytosol;focal adhesion;nucleoplasm;nucleus;RNA polymerase II transcription factor complex;senescence-associated heterochromatin focus;transcription factor complex",{"$nulls":3},5,5,5,"37.4","37.4","37.4","11.676",0,"144.34",9639400000,229,"0.412897",1,"0.487816","0.971168","sp|P17096|HMGA1_HUMAN","sp|P17096|HMGA1_HUMAN",1148,"P17096","HMGA1_HUMAN","High mobility group protein HMG-I/HMG-Y","MG-I(Y)","HMGA1"]
["23.0196","21.231","22.16","22.4607","20.5922","21.9006",{"$nulls":3},"mitotic DNA replication checkpoint;neuron apoptotic process;post-translational protein modification;protein neddylation;regulation of apoptotic process;regulation of neuron apoptotic process;signal transduction","NEDD8 activating enzyme activity;protein heterodimerization activity;ubiquitin protein ligase binding","cytoplasm;cytosol;plasma membrane","Alzheimer disease",null,null,17,17,17,"47.6","47.6","47.6","60.246",0,"297.31",1038700000,66,"0.25486",1,"0.485721","0.641545","sp|Q13564|ULA1_HUMAN;tr|J3QRA5|J3QRA5_HUMAN;tr|H3BMR3|H3BMR3_HUMAN;tr|J3KTE3|J3KTE3_HUMAN;tr|J3KRK3|J3KRK3_HUMAN;tr|J3QLH4|J3QLH4_HUMAN;tr|H3BQW6|H3BQW6_HUMAN","sp|Q13564|ULA1_HUMAN",2382,"Q13564","ULA1_HUMAN","NEDD8-activating enzyme E1 regulatory subunit",null,"NAE1"]
["20.2755","20.0863","19.6108","20.0816","18.6258","19.8104",{"$nulls":4},"ATP binding","mitochondrion",{"$nulls":3},30,1,0,"51.9","1.7",0,"64.243",0,"9.1263",733780000,21,"0.423336",1,"0.484919","0.992161","tr|H0Y2W2|H0Y2W2_HUMAN;tr|Q5SV16|Q5SV16_HUMAN","tr|H0Y2W2|H0Y2W2_HUMAN",5557,"H0Y2W2","H0Y2W2_HUMAN",null,null,"ATAD3A"]
["15.3772","15.2155",1,"16.5224","12.6156",1,{"$nulls":3},"7-methylguanosine cap hypermethylation;7-methylguanosine RNA capping;regulation of lipid metabolic process;regulation of transcription, DNA-templated;ribonucleoprotein complex biogenesis;ribonucleoprotein complex import into nucleus;spliceosomal snRNP assembly;transcription, DNA-templated","RNA methyltransferase activity;RNA trimethylguanosine synthase activity","Cajal body;cytoplasm;cytosol;extracellular space;nucleolus;nucleoplasm;nucleus;small nuclear ribonucleoprotein complex","RNA transport",null,null,6,6,6,"11.5","11.5","11.5","96.619",0,"11.637",50165000,12,"0.0243346",1,"0.484884","0.0727354","sp|Q96RS0|TGS1_HUMAN","sp|Q96RS0|TGS1_HUMAN",4023,"Q96RS0","TGS1_HUMAN","Trimethylguanosine synthase",null,"TGS1"]
["18.359","16.7668","17.7231","17.6594","15.3487","18.3908",{"$nulls":3},"cell division;meiotic cell cycle;negative regulation of DNA endoreduplication;regulation of mitotic spindle assembly;sister chromatid cohesion",null,"chromatin;chromosome;chromosome, centromeric region;cohesin complex;cytosol;membrane;mitotic spindle pole;nuclear matrix;nucleoplasm;nucleus","Cell cycle",null,null,6,6,5,"7.4","7.4","6.6","141.32",0,"19.026",152660000,12,"0.178877",1,"0.483344","0.470657","sp|Q8N3U4|STAG2_HUMAN;tr|B1AMT1|B1AMT1_HUMAN;tr|B1AMT2|B1AMT2_HUMAN;tr|B1AMT3|B1AMT3_HUMAN;tr|B1AMT4|B1AMT4_HUMAN","sp|Q8N3U4|STAG2_HUMAN",3393,"Q8N3U4","STAG2_HUMAN","Cohesin subunit SA-2",null,"STAG2"]
["26.1443","24.9085","25.7223","25.2876","24.427","25.6134",{"$nulls":3},"cellular response to interleukin-4;circadian rhythm;GMP biosynthetic process;GTP biosynthetic process;lymphocyte proliferation;neutrophil degranulation;protein homotetramerization;purine ribonucleoside monophosphate biosynthetic process;retina development in camera-type eye","DNA binding;IMP dehydrogenase activity;metal ion binding;nucleotide binding;RNA binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleus;peroxisomal membrane;secretory granule lumen","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism",null,null,28,28,26,"67.7","67.7","64.8","55.804",0,"323.31",13465000000,395,"0.403365",1,"0.482353","0.951938","sp|P12268|IMDH2_HUMAN;tr|H0Y4R1|H0Y4R1_HUMAN;tr|E7ETK5|E7ETK5_HUMAN","sp|P12268|IMDH2_HUMAN;tr|H0Y4R1|H0Y4R1_HUMAN",1063,"P12268","IMDH2_HUMAN","Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}","MP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156};MPD 2 {ECO:0000255|HAMAP-Rule:MF_03156};MPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}","IMPDH2"]
["20.5759","18.9932","18.9403","20.1268","17.9932","18.9447",{"$nulls":3},"cell cycle G2/M phase transition;mitotic chromosome condensation;mRNA processing;nuclear envelope disassembly;positive regulation of histone deacetylation;positive regulation of transcription from RNA polymerase II promoter;regulation of histone phosphorylation;regulation of mRNA export from nucleus;RNA splicing;transcription, DNA-templated","DEAD/H-box RNA helicase binding;DNA binding;histone deacetylase binding;lamin binding;metal ion binding;protein kinase A regulatory subunit binding;RNA binding","chromatin;cytoplasm;intracellular ribonucleoprotein complex;nuclear matrix;nuclear speck;nucleus;PML body",{"$nulls":3},9,9,9,"21.2","21.2","21.2","71.648",0,"67.401",347590000,30,"0.2309",1,"0.481534","0.588824","sp|Q9ULX6|AKP8L_HUMAN;tr|V9GZ50|V9GZ50_HUMAN;tr|M0R1Y5|M0R1Y5_HUMAN;tr|M0QYT7|M0QYT7_HUMAN;tr|M0R010|M0R010_HUMAN","sp|Q9ULX6|AKP8L_HUMAN;tr|V9GZ50|V9GZ50_HUMAN",5138,"Q9ULX6","AKP8L_HUMAN","A-kinase anchor protein 8-like","KAP8-like protein","AKAP8L"]
["24.9121","22.9363","23.9405","24.2046","22.2635","23.8799",{"$nulls":3},"actin filament depolymerization;actin filament fragmentation;actin filament severing;actin polymerization or depolymerization;positive regulation of actin filament depolymerization","actin filament binding","actin cytoskeleton;cortical actin cytoskeleton;extracellular exosome",{"$nulls":3},8,8,8,"57.6","57.6","57.6","18.506",0,"155.84",1713200000,57,"0.226921",1,"0.480253","0.579974","sp|P60981|DEST_HUMAN;tr|F6RFD5|F6RFD5_HUMAN","sp|P60981|DEST_HUMAN;tr|F6RFD5|F6RFD5_HUMAN",1905,"P60981","DEST_HUMAN","Destrin",null,"DSTN"]
["24.7336","24.0537","24.5648","23.9375","23.7318","24.2492",{"$nulls":3},"2-oxoglutarate metabolic process;female gonad development;glutathione metabolic process;glyoxylate cycle;isocitrate metabolic process;NADPH regeneration;neutrophil degranulation;regulation of phospholipid biosynthetic process;regulation of phospholipid catabolic process;response to oxidative stress;response to steroid hormone;tricarboxylic acid cycle","(R)-2-hydroxyglutarate dehydrogenase activity;cadherin binding;identical protein binding;isocitrate dehydrogenase (NADP+) activity;magnesium ion binding;NAD binding;NADP binding;protein homodimerization activity;receptor binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;mitochondrion;peroxisomal matrix;peroxisome;secretory granule lumen;tertiary granule lumen","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Central carbon metabolism in cancer;Citrate cycle (TCA cycle);Glutathione metabolism;Metabolic pathways;Peroxisome",null,null,19,19,18,"58.7","58.7","56.5","46.659",0,"323.31",5581100000,158,"0.876814",1,"0.477879","1.88315","sp|O75874|IDHC_HUMAN;tr|C9J4N6|C9J4N6_HUMAN;tr|C9JJE5|C9JJE5_HUMAN;tr|C9JLU6|C9JLU6_HUMAN","sp|O75874|IDHC_HUMAN",641,"O75874","IDHC_HUMAN","Isocitrate dehydrogenase [NADP] cytoplasmic","DH","IDH1"]
["18.7795","17.8959","15.0688","17.1269","16.3852","16.8023",{"$nulls":3},"activation of MAPKK activity;cell adhesion;cell adhesion mediated by integrin;cell migration;cell-cell adhesion mediated by integrin;cell-matrix adhesion;cellular response to lipopolysaccharide;integrin-mediated signaling pathway;keratinocyte differentiation;membrane protein ectodomain proteolysis;monocyte activation;PMA-inducible membrane protein ectodomain proteolysis;positive regulation of cell adhesion mediated by integrin;positive regulation of keratinocyte migration;positive regulation of macrophage fusion;positive regulation of membrane protein ectodomain proteolysis;positive regulation of protein secretion;response to calcium ion;response to glucocorticoid;response to hydrogen peroxide;response to laminar fluid shear stress;response to manganese ion;response to tumor necrosis factor;transforming growth factor beta receptor signaling pathway","collagen binding;integrin binding;laminin binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;protein kinase C binding;SH3 domain binding","basolateral plasma membrane;cell surface;extracellular exosome;extracellular space;focal adhesion;integral component of membrane;intrinsic component of external side of plasma membrane",{"$nulls":3},5,5,5,"7.4","7.4","7.4","90.555",0,"10.348",94445000,11,"0.156629",1,"0.47663","0.418281","sp|Q13443|ADAM9_HUMAN;tr|F8WC54|F8WC54_HUMAN;tr|A0AVL1|A0AVL1_HUMAN;tr|A0A0J9YY58|A0A0J9YY58_HUMAN","sp|Q13443|ADAM9_HUMAN;tr|F8WC54|F8WC54_HUMAN;tr|A0AVL1|A0AVL1_HUMAN",2360,"Q13443","ADAM9_HUMAN","Disintegrin and metalloproteinase domain-containing protein 9","DAM 9","ADAM9"]
["24.0057","22.2671","23.2496","23.3495","21.8296","22.9199",{"$nulls":3},"carbohydrate metabolic process;ethanol catabolic process;ethanol oxidation","aldehyde dehydrogenase (NAD) activity;NAD binding","intracellular membrane-bounded organelle;mitochondrial matrix;mitochondrion;nucleoplasm","Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Fatty acid degradation;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Lysine degradation;Metabolic pathways;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,25,22,22,"48.4","45.1","45.1","57.206",0,"288.62",2015100000,105,"0.282446",1,"0.474478","0.70114","sp|P30837|AL1B1_HUMAN","sp|P30837|AL1B1_HUMAN",1394,"P30837","AL1B1_HUMAN","Aldehyde dehydrogenase X, mitochondrial",null,"ALDH1B1"]
["28.4873","25.9336","26.2228","26.8823","25.6882","26.652",{"$nulls":3},"erythrocyte homeostasis;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleoplasm;ribosome","Ribosome",null,null,10,10,10,"62.2","62.2","62.2","15.55",0,"323.31",37550000000,504,"0.20668",1,"0.473747","0.534492","sp|P08708|RS17_HUMAN;tr|H0YN88|H0YN88_HUMAN;tr|A0A075B716|A0A075B716_HUMAN;tr|H0YN73|H0YN73_HUMAN;tr|H3BNC9|H3BNC9_HUMAN","sp|P08708|RS17_HUMAN;tr|H0YN88|H0YN88_HUMAN;tr|A0A075B716|A0A075B716_HUMAN",972,"P08708","RS17_HUMAN","40S ribosomal protein S17 {ECO:0000305}",null,"RPS17"]
["23.6042","22.4833","23.4594","23.4206","21.7704","22.945",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of viral transcription;response to virus;RNA metabolic process;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","DNA binding;phosphatase activator activity;protein domain specific binding;protein phosphatase binding;RNA binding;transcription coactivator activity;transcription factor binding","cell junction;intracellular membrane-bounded organelle;nucleoplasm;nucleus;protein complex;transcription factor TFIID complex;transcription factor TFIIF complex","Basal transcription factors",null,null,23,23,23,"50.7","50.7","50.7","58.24",0,"323.31",4348500000,281,"0.319262",1,"0.470306","0.779093","sp|P35269|T2FA_HUMAN;tr|M0QXD6|M0QXD6_HUMAN;tr|M0R0R9|M0R0R9_HUMAN;tr|M0R0Z3|M0R0Z3_HUMAN","sp|P35269|T2FA_HUMAN;tr|M0QXD6|M0QXD6_HUMAN;tr|M0R0R9|M0R0R9_HUMAN",1458,"P35269","T2FA_HUMAN","General transcription factor IIF subunit 1",null,"GTF2F1"]
["20.2525","18.0697","19.5563","19.1573","17.9245","19.3881",{"$nulls":3},"cellular protein metabolic process;intracellular protein transport;positive regulation of protein catabolic process;toxin transport;vesicle-mediated transport","ADP-ribosylation factor binding;protein heterodimerization activity","clathrin adaptor complex;early endosome membrane;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;membrane;nucleoplasm;protein complex","Lysosome",null,null,8,7,7,"16.9","15.8","15.8","70.383",0,"84.421",156170000,13,"0.234096",1,"0.469519","0.595912","sp|Q9UJY5|GGA1_HUMAN;tr|B0QYR6|B0QYR6_HUMAN;tr|B0QYS5|B0QYS5_HUMAN;tr|B0QYR9|B0QYR9_HUMAN;tr|B0QYS0|B0QYS0_HUMAN;tr|B0QYS1|B0QYS1_HUMAN;tr|A0A087WYN2|A0A087WYN2_HUMAN;tr|B0QYS2|B0QYS2_HUMAN;tr|B0QYS3|B0QYS3_HUMAN;tr|B0QYR5|B0QYR5_HUMAN;tr|H3BPI3|H3BPI3_HUMAN","sp|Q9UJY5|GGA1_HUMAN;tr|B0QYR6|B0QYR6_HUMAN",5073,"Q9UJY5","GGA1_HUMAN","ADP-ribosylation factor-binding protein GGA1",null,"GGA1"]
["16.6018","15.9028","17.2264","16.253","15.4496","16.6224",{"$nulls":9},2,2,2,"7.3","7.3","7.3","43.196","0.0024899","2.9824",20261000,1,"0.382036",1,"0.468644","0.908673","tr|A0A0A0MQT4|A0A0A0MQT4_HUMAN;sp|Q5QP82|DCA10_HUMAN","tr|A0A0A0MQT4|A0A0A0MQT4_HUMAN;sp|Q5QP82|DCA10_HUMAN",2841,"A0A0A0MQT4","A0A0A0MQT4_HUMAN",null,null,"DCAF10"]
["22.0731","21.5242","21.7895","21.0725","20.9963","21.9164",{"$nulls":3},"cap-independent translational initiation;cell differentiation;circadian regulation of translation;entrainment of circadian clock by photoperiod;IRES-dependent translational initiation of linear mRNA;miRNA mediated inhibition of translation;mRNA processing;negative regulation of translation;negative regulation of translation in response to stress;negative regulation of translational initiation;positive regulation of muscle cell differentiation;regulation of alternative mRNA splicing, via spliceosome;regulation of nucleocytoplasmic transport;response to arsenic-containing substance;RNA processing;RNA splicing","cyclin binding;miRNA binding;mRNA 3'-UTR binding;mRNA binding;pre-mRNA intronic binding;pre-mRNA intronic pyrimidine-rich binding;RNA binding;zinc ion binding","cytoplasm;cytoplasmic stress granule;cytosol;nuclear speck;nucleolus;nucleoplasm;nucleus",{"$nulls":3},11,11,2,"36.3","36.3","12.1","40.313",0,"83.933",624480000,45,"0.628371",1,"0.467178","1.39566","sp|Q9BWF3|RBM4_HUMAN;tr|E9PB51|E9PB51_HUMAN;tr|E9PLB0|E9PLB0_HUMAN;tr|E9PM61|E9PM61_HUMAN;tr|D6R9K7|D6R9K7_HUMAN;tr|U3KQD5|U3KQD5_HUMAN;tr|J3QRR5|J3QRR5_HUMAN","sp|Q9BWF3|RBM4_HUMAN;tr|E9PB51|E9PB51_HUMAN",4279,"Q9BWF3","RBM4_HUMAN","RNA-binding protein 4",null,"RBM4"]
["23.0844","21.6984","22.7467","23.016","20.7852","22.3287",{"$nulls":3},"endosome to lysosome transport;membrane organization;receptor-mediated endocytosis;secretion of lysosomal enzymes","mannose binding;mannose transmembrane transporter activity;retromer complex binding;transmembrane signaling receptor activity","clathrin-coated vesicle membrane;endosome;integral component of plasma membrane;late endosome;lysosomal membrane;membrane;perinuclear region of cytoplasm;plasma membrane;trans-Golgi network;trans-Golgi network membrane;transport vesicle","Lysosome;Phagosome",null,null,3,3,3,"19.1","19.1","19.1","30.993",0,"31.485",634120000,39,"0.234929",1,"0.466548","0.597756","sp|P20645|MPRD_HUMAN;tr|F5GX30|F5GX30_HUMAN;tr|F5GXE0|F5GXE0_HUMAN;tr|H0YGE9|H0YGE9_HUMAN;tr|F5GXU0|F5GXU0_HUMAN;tr|H0YGT2|H0YGT2_HUMAN;tr|F5H883|F5H883_HUMAN;tr|H0YF90|H0YF90_HUMAN","sp|P20645|MPRD_HUMAN;tr|F5GX30|F5GX30_HUMAN",1214,"P20645","MPRD_HUMAN","Cation-dependent mannose-6-phosphate receptor","D Man-6-P receptor;D-MPR","M6PR"]
["22.4539","21.3756","20.5803","21.614","20.8961","20.5093",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","cytosol;mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion","Ribosome",null,null,4,4,4,"43.1","43.1","43.1","15.345",0,"20.102",325750000,33,"0.297547",1,"0.463498","0.733317","sp|Q9Y3D3|RT16_HUMAN;tr|A6ND22|A6ND22_HUMAN","sp|Q9Y3D3|RT16_HUMAN;tr|A6ND22|A6ND22_HUMAN",5292,"Q9Y3D3","RT16_HUMAN","28S ribosomal protein S16, mitochondrial","16mt;RP-S16","MRPS16"]
["23.2683","21.4552","22.5139","22.8922","20.6672","22.2901",{"$nulls":5},"integral component of membrane",{"$nulls":3},4,4,4,18,18,18,"25.223",0,"25.235",648750000,40,"0.211744",1,"0.462612","0.545945","tr|D6RAA6|D6RAA6_HUMAN;sp|P57088|TMM33_HUMAN;tr|H0Y8N0|H0Y8N0_HUMAN;tr|J3KN43|J3KN43_HUMAN;tr|D6RBY2|D6RBY2_HUMAN","tr|D6RAA6|D6RAA6_HUMAN;sp|P57088|TMM33_HUMAN;tr|H0Y8N0|H0Y8N0_HUMAN",1876,"D6RAA6","D6RAA6_HUMAN",null,null,"TMEM33"]
["18.9611","17.6038","17.0902","19.2377","16.6157","16.4141",{"$nulls":3},"carbohydrate metabolic process;chitin catabolic process;innate immune response;negative regulation of cytokine production involved in inflammatory response;platelet degranulation","chitin binding;chitinase activity;oligosaccharide binding","extracellular exosome;extracellular region;extracellular space;late endosome;lysosomal lumen;lysosome;membrane;nucleus;trans-Golgi network",{"$nulls":3},4,4,4,"11.7","11.7","11.7","44.94",0,"6.8832",56310000,3,"0.16302",1,"0.462518","0.433454","sp|Q9BWS9|CHID1_HUMAN;tr|E9PI70|E9PI70_HUMAN;tr|E9PIP0|E9PIP0_HUMAN;tr|E9PRL3|E9PRL3_HUMAN;tr|E9PPH0|E9PPH0_HUMAN;tr|E9PPA0|E9PPA0_HUMAN;tr|H0YDL6|H0YDL6_HUMAN;tr|E9PKF1|E9PKF1_HUMAN;tr|H0YCC4|H0YCC4_HUMAN;tr|H0YC89|H0YC89_HUMAN","sp|Q9BWS9|CHID1_HUMAN;tr|E9PI70|E9PI70_HUMAN;tr|E9PIP0|E9PIP0_HUMAN;tr|E9PRL3|E9PRL3_HUMAN;tr|E9PPH0|E9PPH0_HUMAN;tr|E9PPA0|E9PPA0_HUMAN",4284,"Q9BWS9","CHID1_HUMAN","Chitinase domain-containing protein 1",null,"CHID1"]
["23.1461","22.0362","22.1869","22.8832","20.9767","22.1253",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","cell junction;mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleoplasm","Viral carcinogenesis",null,null,9,9,9,"55.8","55.8","55.8","29.395",0,"106.86",765180000,68,"0.284344",1,"0.461317","0.7052","sp|Q9Y676|RT18B_HUMAN;tr|A0A0G2JIC6|A0A0G2JIC6_HUMAN","sp|Q9Y676|RT18B_HUMAN;tr|A0A0G2JIC6|A0A0G2JIC6_HUMAN",5392,"Q9Y676","RT18B_HUMAN","28S ribosomal protein S18b, mitochondrial","18mt-b;rps18-b;RP-S18-b","MRPS18B"]
["19.7634",1,"19.3961","18.487",1,"19.2967",{"$nulls":3},"activation of cysteine-type endopeptidase activity;activation of cysteine-type endopeptidase activity involved in apoptotic process;activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;apoptotic process;apoptotic signaling pathway;behavioral response to cocaine;cell surface receptor signaling pathway;cellular response to mechanical stimulus;death-inducing signaling complex assembly;defense response to virus;extrinsic apoptotic signaling pathway;extrinsic apoptotic signaling pathway in absence of ligand;extrinsic apoptotic signaling pathway via death domain receptors;innate immune response;lymph node development;motor neuron apoptotic process;necroptotic signaling pathway;negative regulation of activation-induced cell death of T cells;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of necroptotic process;positive regulation of activated T cell proliferation;positive regulation of adaptive immune response;positive regulation of apoptotic process;positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-gamma production;positive regulation of interleukin-8 production;positive regulation of macrophage differentiation;positive regulation of proteolysis;positive regulation of T cell mediated cytotoxicity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor production;positive regulation of type I interferon-mediated signaling pathway;regulation of extrinsic apoptotic signaling pathway via death domain receptors;response to morphine;spleen development;T cell differentiation in thymus;T cell homeostasis;thymus development;toll-like receptor 3 signaling pathway;TRAIL-activated apoptotic signaling pathway;TRIF-dependent toll-like receptor signaling pathway;viral process","caspase binding;death effector domain binding;death receptor binding;identical protein binding;protease binding;protein complex binding;receptor serine/threonine kinase binding;tumor necrosis factor receptor binding;tumor necrosis factor receptor superfamily binding","CD95 death-inducing signaling complex;cell body;cytoplasm;cytosol;death-inducing signaling complex;membrane raft;neuron projection;nucleus;plasma membrane;ripoptosome","Alzheimer disease;Apoptosis;Apoptosis - multiple species;Chagas disease (American trypanosomiasis);Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;IL-17 signaling pathway;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;Necroptosis;NOD-like receptor signaling pathway;Pathways in cancer;Platinum drug resistance;RIG-I-like receptor signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Tuberculosis",null,null,2,2,2,"14.9","14.9","14.9","23.279",0,"30.496",24911000,5,"0.017712",1,"0.458609","0.0533154","sp|Q13158|FADD_HUMAN","sp|Q13158|FADD_HUMAN",2318,"Q13158","FADD_HUMAN","FAS-associated death domain protein",null,"FADD"]
["19.3735","18.5167","18.6339","18.3499","17.9987","18.8073",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA processing","RNA binding;snoRNA binding","nucleolus;nucleoplasm;nucleus;Pwp2p-containing subcomplex of 90S preribosome;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,17,17,17,"30.1","30.1","30.1","89.034",0,"158.21",1099500000,124,"0.569638",1,"0.456095","1.28113","sp|Q12788|TBL3_HUMAN;tr|J3KNP2|J3KNP2_HUMAN;tr|A0A087WYP7|A0A087WYP7_HUMAN;tr|H3BN88|H3BN88_HUMAN","sp|Q12788|TBL3_HUMAN;tr|J3KNP2|J3KNP2_HUMAN",2258,"Q12788","TBL3_HUMAN","Transducin beta-like protein 3",null,"TBL3"]
["21.3212","18.8425","19.8577","21.112","17.7727","19.7729",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;histone mRNA metabolic process;mRNA 3'-end processing;mRNA cis splicing, via spliceosome;mRNA export from nucleus;mRNA splicing, via spliceosome;nuclear export;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of cell growth;positive regulation of mRNA 3'-end processing;positive regulation of mRNA splicing, via spliceosome;positive regulation of RNA binding;pre-mRNA cleavage required for polyadenylation;primary miRNA processing;regulation of translational initiation;RNA export from nucleus;RNA metabolic process;RNA splicing;snRNA transcription from RNA polymerase II promoter;spliceosomal complex assembly;termination of RNA polymerase II transcription;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","mRNA binding;RNA 7-methylguanosine cap binding;RNA binding;RNA cap binding","cytosol;intracellular ribonucleoprotein complex;mitochondrion;mRNA cap binding complex;nuclear cap binding complex;nucleoplasm;nucleus;RNA cap binding complex","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,13,13,13,"22.4","22.4","22.4","91.838",0,"73.737",444760000,39,"0.139208",1,"0.454603","0.376365","sp|Q09161|NCBP1_HUMAN;tr|F2Z2T1|F2Z2T1_HUMAN;tr|X6R941|X6R941_HUMAN","sp|Q09161|NCBP1_HUMAN",2244,"Q09161","NCBP1_HUMAN","Nuclear cap-binding protein subunit 1",null,"NCBP1"]
["25.624","24.0901","24.3873","24.9505","23.7526","24.0422",{"$nulls":3},"formaldehyde catabolic process;glutathione derivative biosynthetic process","carboxylic ester hydrolase activity;hydrolase activity, acting on ester bonds;identical protein binding;methylumbelliferyl-acetate deacetylase activity;S-formylglutathione hydrolase activity","cytoplasmic vesicle;endoplasmic reticulum lumen;extracellular exosome","Carbon metabolism;Metabolic pathways",null,null,13,13,13,"74.8","74.8","74.8","31.462",0,"323.31",13100000000,123,"0.311686",1,"0.452025","0.763186","sp|P10768|ESTD_HUMAN;tr|X6RA14|X6RA14_HUMAN;tr|H7BZT7|H7BZT7_HUMAN;tr|U3KQT1|U3KQT1_HUMAN","sp|P10768|ESTD_HUMAN;tr|X6RA14|X6RA14_HUMAN;tr|H7BZT7|H7BZT7_HUMAN",1028,"P10768","ESTD_HUMAN","S-formylglutathione hydrolase","GH","ESD"]
["22.5737","20.7774","21.33","22.0075","20.125","21.1992",{"$nulls":5},"endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},2,2,2,"12.6","12.6","12.6","17.221",0,"10.645",160610000,10,"0.231809",1,"0.449757","0.590842","tr|E5RGY0|E5RGY0_HUMAN;tr|B4E1G1|B4E1G1_HUMAN;sp|Q9BUN8|DERL1_HUMAN","tr|E5RGY0|E5RGY0_HUMAN;tr|B4E1G1|B4E1G1_HUMAN;sp|Q9BUN8|DERL1_HUMAN",4231,"E5RGY0","E5RGY0_HUMAN","Derlin {ECO:0000256|RuleBase:RU363059}",null,"DERL1"]
["15.0432","15.9854",1,1,"14.8006","14.8877",{"$nulls":3},"apoptotic process;mRNA splicing, via spliceosome;negative regulation of cell proliferation;positive regulation of apoptotic process;regulation of alternative mRNA splicing, via spliceosome;RNA processing;spliceosomal complex assembly","DNA binding;metal ion binding;mRNA binding;RNA binding","nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},3,3,3,5,5,5,"92.153",0,"6.9867",22511000,7,"0.0222863",1,"0.446713","0.0667574","sp|P52756|RBM5_HUMAN","sp|P52756|RBM5_HUMAN",1780,"P52756","RBM5_HUMAN","RNA-binding protein 5",null,"RBM5"]
["19.9021",1,"18.4069","18.5656",1,"18.404",{"$nulls":4},"GTP binding",{"$nulls":4},2,2,2,"9.3","9.3","9.3","26.422","0.0004258","4.7852",61763000,5,"0.0176288",1,"0.446473","0.0530697","sp|Q5HYI8|RABL3_HUMAN;tr|H7C533|H7C533_HUMAN;tr|F8WAX9|F8WAX9_HUMAN;tr|F8WF50|F8WF50_HUMAN;tr|F8WDC7|F8WDC7_HUMAN;tr|C9JXM3|C9JXM3_HUMAN","sp|Q5HYI8|RABL3_HUMAN;tr|H7C533|H7C533_HUMAN;tr|F8WAX9|F8WAX9_HUMAN;tr|F8WF50|F8WF50_HUMAN;tr|F8WDC7|F8WDC7_HUMAN;tr|C9JXM3|C9JXM3_HUMAN",2816,"Q5HYI8","RABL3_HUMAN","Rab-like protein 3",null,"RABL3"]
["24.1399","23.2528","23.9778","23.7859","22.6081","23.6425",{"$nulls":3},"antibacterial humoral response;antigen processing and presentation of endogenous peptide antigen via MHC class I;antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;defense response to Gram-positive bacterium;interferon-gamma-mediated signaling pathway;positive regulation of CD8-positive, alpha-beta T cell activation;positive regulation of CD8-positive, alpha-beta T cell proliferation;positive regulation of interferon-gamma production;positive regulation of memory T cell activation;positive regulation of T cell cytokine production;positive regulation of T cell mediated cytotoxicity;protein heterotetramerization;protein ubiquitination;regulation of defense response to virus by virus;regulation of immune response;type I interferon signaling pathway","beta-2-microglobulin binding;peptide antigen binding;receptor binding;RNA binding;T cell receptor binding;TAP binding","cell surface;early endosome membrane;endoplasmic reticulum;endoplasmic reticulum exit site;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi medial cisterna;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},16,16,1,"48.8","48.8","4.9","40.921",0,"149.84",2837200000,128,"0.410189",1,"0.444693","0.965711","sp|P01892|1A02_HUMAN;tr|A0A0G2JNY4|A0A0G2JNY4_HUMAN","sp|P01892|1A02_HUMAN;tr|A0A0G2JNY4|A0A0G2JNY4_HUMAN",848,"P01892","1A02_HUMAN","HLA class I histocompatibility antigen, A-2 alpha chain",null,"HLA-A"]
["17.7255","16.913","17.6718","17.5548","15.4745","17.9501",{"$nulls":3},"cellular response to ionizing radiation;DNA damage checkpoint;snRNA 3'-end processing;snRNA processing;snRNA transcription from RNA polymerase II promoter","lipid transporter activity","chromosome;cytoplasm;cytosol;integrator complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"6.7","6.7","6.7","106.83",0,"13.656",199280000,11,"0.212083",1,"0.443626","0.546712","sp|Q9NVH2|INT7_HUMAN;tr|A0A087WXK3|A0A087WXK3_HUMAN","sp|Q9NVH2|INT7_HUMAN",4762,"Q9NVH2","INT7_HUMAN","Integrator complex subunit 7","nt7","INTS7"]
["19.0118","15.9169",1,"17.6718",1,"15.9302",{"$nulls":3},"iron ion homeostasis","ion transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane",{"$nulls":3},4,4,4,"17.1","17.1","17.1","36.231",0,"7.976",23273000,4,"0.0191708",1,"0.442227","0.0576162","sp|Q96NB2|SFXN2_HUMAN;tr|R4GMR9|R4GMR9_HUMAN;tr|R4GN74|R4GN74_HUMAN;tr|R4GNC2|R4GNC2_HUMAN;tr|R4GN63|R4GN63_HUMAN;tr|A0A0K0K1C2|A0A0K0K1C2_HUMAN;tr|R4GMW0|R4GMW0_HUMAN;tr|A0A0C4DGR6|A0A0C4DGR6_HUMAN","sp|Q96NB2|SFXN2_HUMAN;tr|R4GMR9|R4GMR9_HUMAN;tr|R4GN74|R4GN74_HUMAN;tr|R4GNC2|R4GNC2_HUMAN;tr|R4GN63|R4GN63_HUMAN;tr|A0A0K0K1C2|A0A0K0K1C2_HUMAN;tr|R4GMW0|R4GMW0_HUMAN;tr|A0A0C4DGR6|A0A0C4DGR6_HUMAN",3982,"Q96NB2","SFXN2_HUMAN","Sideroflexin-2",null,"SFXN2"]
["20.3848","19.0749","19.0487","19.2735","17.9204","19.9897",{"$nulls":3},"iron ion homeostasis","ion transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane",{"$nulls":3},5,5,5,"21.1","21.1","21.1","37.998",0,"21.899",190050000,21,"0.230859",1,"0.441593","0.588732","sp|Q6P4A7|SFXN4_HUMAN","sp|Q6P4A7|SFXN4_HUMAN",3012,"Q6P4A7","SFXN4_HUMAN","Sideroflexin-4",null,"SFXN4"]
["16.7575","14.8823","15.9687","15.929","14.5443","15.8162",{"$nulls":3},"microtubule-based movement;spindle assembly","ATP binding;cholesterol binding;microtubule binding;microtubule motor activity","centriole;cytoplasm;nucleus",{"$nulls":3},2,2,2,"0.4","0.4","0.4","516.34","0.0057418","2.4241",141040000,5,"0.247937",1,"0.439644","0.626409","sp|Q9P2P6|STAR9_HUMAN","sp|Q9P2P6|STAR9_HUMAN",4938,"Q9P2P6","STAR9_HUMAN","StAR-related lipid transfer protein 9",null,"STARD9"]
["23.4545","22.8555","22.9394","22.9607","22.2594","22.7114",{"$nulls":3},"dopaminergic neuron differentiation;neuron projection development;platelet degranulation;response to unfolded protein","growth factor activity;RNA binding","cytosol;endoplasmic reticulum;extracellular region;extracellular space;nucleus",{"$nulls":3},7,7,7,"37.9","37.9","37.9","20.7",0,"48.06",787470000,47,"0.723555",1,"0.439293","1.58119","sp|P55145|MANF_HUMAN;tr|A8K878|A8K878_HUMAN;tr|H7C2D6|H7C2D6_HUMAN","sp|P55145|MANF_HUMAN;tr|A8K878|A8K878_HUMAN",1839,"P55145","MANF_HUMAN","Mesencephalic astrocyte-derived neurotrophic factor",null,"MANF"]
["21.4265","19.7363","20.7158","20.6937","19.5229","20.3474",{"$nulls":3},"apoptotic process;autophagy;cellular response to cobalt ion;cellular response to DNA damage stimulus;cellular response to hypoxia;fructose 1,6-bisphosphate metabolic process;fructose 2,6-bisphosphate metabolic process;intestinal epithelial cell development;negative regulation of glucose catabolic process to lactate via pyruvate;negative regulation of glycolytic process;negative regulation of mitophagy;negative regulation of neuron death;negative regulation of programmed cell death;negative regulation of reactive oxygen species metabolic process;positive regulation of cardiac muscle cell apoptotic process;positive regulation of DNA repair;positive regulation of hexokinase activity;regulation of pentose-phosphate shunt;regulation of response to DNA damage checkpoint signaling;response to gamma radiation;response to ischemia;response to xenobiotic stimulus","bisphosphoglycerate 2-phosphatase activity;fructose-2,6-bisphosphate 2-phosphatase activity","cytoplasm;cytosol;intracellular;mitochondrial outer membrane;nucleus","Central carbon metabolism in cancer;Fructose and mannose metabolism;Metabolic pathways",null,null,6,6,6,"34.4","34.4","34.4","30.062",0,"35.069",240970000,25,"0.295841",1,"0.438227","0.729695","sp|Q9NQ88|TIGAR_HUMAN","sp|Q9NQ88|TIGAR_HUMAN",4652,"Q9NQ88","TIGAR_HUMAN","Fructose-2,6-bisphosphatase TIGAR {ECO:0000305}",null,"TIGAR"]
["23.2549","21.9962","22.4763","22.5437","21.5319","22.3378",{"$nulls":3},"isoleucyl-tRNA aminoacylation;tRNA aminoacylation for protein translation","aminoacyl-tRNA editing activity;ATP binding;isoleucine-tRNA ligase activity;tRNA binding","cytosol;mitochondrial matrix;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,35,35,35,"47.1","47.1","47.1","113.79",0,"238.03",2052600000,130,"0.384497",1,"0.438006","0.913684","sp|Q9NSE4|SYIM_HUMAN","sp|Q9NSE4|SYIM_HUMAN",4713,"Q9NSE4","SYIM_HUMAN","Isoleucine--tRNA ligase, mitochondrial",null,"IARS2"]
["21.7576","20.3645","20.1668","20.624","20.2221","20.135",{"$nulls":3},"intrinsic apoptotic signaling pathway in response to oxidative stress;positive regulation of apoptotic process;positive regulation of JNK cascade;positive regulation of kinase activity;positive regulation of MAPK cascade;ribosomal large subunit biogenesis","RNA binding;zinc ion binding","cytosol;cytosolic large ribosomal subunit;Golgi apparatus;nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},10,10,10,"28.9","28.9","28.9","54.271",0,"54.754",410730000,34,"0.345633",1,"0.435956","0.833983","sp|Q969S3|ZN622_HUMAN","sp|Q969S3|ZN622_HUMAN",3766,"Q969S3","ZN622_HUMAN","Zinc finger protein 622",null,"ZNF622"]
["23.5142","21.4653","22.3932","22.9595","21.1978","21.9154",{"$nulls":3},"ether lipid biosynthetic process;lipid biosynthetic process","alkylglycerone-phosphate synthase activity;FAD binding;oxidoreductase activity, acting on CH-OH group of donors","membrane;mitochondrion;nucleolus;peroxisomal matrix;peroxisomal membrane;peroxisome","Ether lipid metabolism;Metabolic pathways;Peroxisome",null,null,24,24,24,"48.9","48.9","48.9","72.911",0,"260.35",1948300000,137,"0.215197",1,"0.433352","0.553727","sp|O00116|ADAS_HUMAN;tr|B8ZZ81|B8ZZ81_HUMAN","sp|O00116|ADAS_HUMAN",199,"O00116","ADAS_HUMAN","Alkyldihydroxyacetonephosphate synthase, peroxisomal","lkyl-DHAP synthase","AGPS"]
["18.173","17.2006","17.0162","15.8642","17.4121","17.8164",{"$nulls":3},"RNA processing;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;nucleolus;nucleoplasm",{"$nulls":3},13,13,13,"14.5","14.5","14.5","129.54",0,"43.401",384810000,56,"0.246052",1,"0.432336","0.622276","sp|Q8IY37|DHX37_HUMAN;tr|F5H3Y4|F5H3Y4_HUMAN","sp|Q8IY37|DHX37_HUMAN;tr|F5H3Y4|F5H3Y4_HUMAN",3332,"Q8IY37","DHX37_HUMAN","Probable ATP-dependent RNA helicase DHX37",null,"DHX37"]
["22.2428","21.3906","21.6703","21.7949","20.8964","21.3161",{"$nulls":4},"carbohydrate binding","integral component of membrane;membrane",{"$nulls":3},31,31,2,"36.3","36.3","1.4","134.32",0,"323.31",2057400000,172,"0.52675",1,"0.432098","1.19717","sp|Q15155|NOMO1_HUMAN;tr|A0A0G2JN29|A0A0G2JN29_HUMAN;tr|A0A087X117|A0A087X117_HUMAN;tr|A0A0G2JP90|A0A0G2JP90_HUMAN;tr|A0A087WW46|A0A087WW46_HUMAN;tr|H3BUC9|H3BUC9_HUMAN;tr|H3BPS9|H3BPS9_HUMAN","sp|Q15155|NOMO1_HUMAN;tr|A0A0G2JN29|A0A0G2JN29_HUMAN;tr|A0A087X117|A0A087X117_HUMAN;tr|A0A0G2JP90|A0A0G2JP90_HUMAN;tr|A0A087WW46|A0A087WW46_HUMAN",2567,"Q15155","NOMO1_HUMAN","Nodal modulator 1",null,"NOMO1"]
["17.0922","17.8424","18.724","16.4649","16.8965","19.0076",{"$nulls":4},"5'-nucleotidase activity;metal ion binding","receptor complex",{"$nulls":3},6,6,6,"16.8","16.8","16.8","63.419",0,"13.603",68016000,7,"0.178227",1,"0.42985","0.469144","sp|Q86UY8|NT5D3_HUMAN;tr|H7C193|H7C193_HUMAN;tr|H7C3S8|H7C3S8_HUMAN","sp|Q86UY8|NT5D3_HUMAN",3225,"Q86UY8","NT5D3_HUMAN","5'-nucleotidase domain-containing protein 3",null,"NT5DC3"]
["17.7425","17.3109","18.7006","17.422","16.6904","18.3539",{"$nulls":3},"androgen biosynthetic process;androgen receptor signaling pathway;angiogenesis;animal organ regeneration;brain development;cell morphogenesis;cellular response to epidermal growth factor stimulus;cellular response to hepatocyte growth factor stimulus;cellular response to steroid hormone stimulus;cellular response to thyroid hormone stimulus;embryonic heart tube development;embryonic hemopoiesis;embryonic hindlimb morphogenesis;embryonic placenta development;enucleate erythrocyte development;epithelial cell proliferation involved in mammary gland duct elongation;ERK1 and ERK2 cascade;erythrocyte development;fat cell differentiation;intracellular steroid hormone receptor signaling pathway;keratinocyte differentiation;lactation;lens development in camera-type eye;liver development;mammary gland branching involved in pregnancy;mammary gland branching involved in thelarche;megakaryocyte development;monocyte differentiation;mRNA transcription from RNA polymerase II promoter;negative regulation of apoptotic process;negative regulation of keratinocyte proliferation;negative regulation of neuron differentiation;negative regulation of transcription from RNA polymerase II promoter;peroxisome proliferator activated receptor signaling pathway;positive regulation of erythrocyte differentiation;positive regulation of G0 to G1 transition;positive regulation of gene expression;positive regulation of hepatocyte proliferation;positive regulation of interferon-gamma-mediated signaling pathway;positive regulation of intracellular estrogen receptor signaling pathway;positive regulation of keratinocyte differentiation;positive regulation of mammary gland epithelial cell proliferation;positive regulation of protein import into nucleus, translocation;positive regulation of receptor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of cell cycle;regulation of lipid metabolic process;regulation of RNA biosynthetic process;regulation of transcription from RNA polymerase I promoter;regulation of vitamin D receptor signaling pathway;retinal pigment epithelium development;thyroid hormone generation;thyroid hormone mediated signaling pathway;transcription initiation from RNA polymerase II promoter;ventricular trabecula myocardium morphogenesis","chromatin binding;chromatin DNA binding;core promoter binding;estrogen receptor binding;LBD domain binding;ligand-dependent nuclear receptor binding;ligand-dependent nuclear receptor transcription coactivator activity;mediator complex binding;nuclear hormone receptor binding;peroxisome proliferator activated receptor binding;receptor activity;retinoic acid receptor binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription cofactor activity;RNA polymerase II transcription factor activity, sequence-specific DNA binding;thyroid hormone receptor binding;thyroid hormone receptor coactivator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;ubiquitin protein ligase activity;vitamin D receptor binding","chromatin;mediator complex;membrane;nucleolus;nucleoplasm;nucleus;protein-DNA complex;ubiquitin ligase complex","Endocrine resistance;Thyroid hormone signaling pathway",null,null,33,33,33,"31.2","31.2","31.2","168.48",0,"199.49",941100000,118,"0.271836",1,"0.429217","0.67835","sp|Q15648|MED1_HUMAN;tr|J3QKZ7|J3QKZ7_HUMAN;tr|J3KSD7|J3KSD7_HUMAN","sp|Q15648|MED1_HUMAN",2627,"Q15648","MED1_HUMAN","Mediator of RNA polymerase II transcription subunit 1",null,"MED1"]
["19.6518","19.3159","19.1961","19.1695","18.8761","18.8331",{"$nulls":3},"mRNA transport;protein export from nucleus","nuclear export signal receptor activity;Ran GTPase binding","cytoplasm;nuclear pore;nucleus",{"$nulls":3},17,17,17,18,18,18,"123.91",0,"51.447",368470000,40,"1.16713",1,"0.428343","2.48212","sp|Q9UIA9|XPO7_HUMAN;tr|E7ESC6|E7ESC6_HUMAN;tr|H0YBE1|H0YBE1_HUMAN;tr|E5RIW1|E5RIW1_HUMAN","sp|Q9UIA9|XPO7_HUMAN;tr|E7ESC6|E7ESC6_HUMAN",5047,"Q9UIA9","XPO7_HUMAN","Exportin-7","xp7","XPO7"]
["25.7647","26.0204","25.603","24.8987","25.5924","25.6127",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;membrane;nucleolus","Ribosome",null,null,6,6,6,"37.1","37.1","37.1","12.254",0,"27.767",1501800000,56,"0.743338",1,"0.428076","1.61986","sp|Q9Y3U8|RL36_HUMAN;tr|J3QSB5|J3QSB5_HUMAN;tr|J3KTD3|J3KTD3_HUMAN","sp|Q9Y3U8|RL36_HUMAN;tr|J3QSB5|J3QSB5_HUMAN",5307,"Q9Y3U8","RL36_HUMAN","60S ribosomal protein L36",null,"RPL36"]
["21.1819","21.0415","21.1229","20.7055","20.4176","20.9418",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","enzyme binding;histone binding;histone deacetylase binding;metal ion binding;phosphoprotein binding;ribonucleoprotein complex binding;RNA binding;scaffold protein binding;sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;tubulin binding","condensed chromosome kinetochore;nucleolus;nucleoplasm;nucleus",{"$nulls":3},12,12,12,"35.9","35.9","35.9","41.29",0,"282.97",2245600000,120,"1.27677",1,"0.427155","2.72208","sp|Q8IWS0|PHF6_HUMAN;tr|A0A0D9SGE8|A0A0D9SGE8_HUMAN;tr|Q5JRC6|Q5JRC6_HUMAN","sp|Q8IWS0|PHF6_HUMAN;tr|A0A0D9SGE8|A0A0D9SGE8_HUMAN;tr|Q5JRC6|Q5JRC6_HUMAN",3308,"Q8IWS0","PHF6_HUMAN","PHD finger protein 6",null,"PHF6"]
["21.3604","20.7615","20.7784","20.4161","19.7195","21.4904",{"$nulls":4},"4 iron, 4 sulfur cluster binding;metal ion binding;NADH dehydrogenase (ubiquinone) activity;quinone binding",{"$nulls":4},4,4,4,"21.4","21.4","21.4","19.77",0,"16.59",278670000,31,"0.315086",1,"0.424774","0.770333","tr|F5H5N1|F5H5N1_HUMAN;sp|O75251|NDUS7_HUMAN;tr|F5GXJ1|F5GXJ1_HUMAN;tr|A0A087WXF6|A0A087WXF6_HUMAN;tr|A0A087WTI3|A0A087WTI3_HUMAN","tr|F5H5N1|F5H5N1_HUMAN;sp|O75251|NDUS7_HUMAN;tr|F5GXJ1|F5GXJ1_HUMAN;tr|A0A087WXF6|A0A087WXF6_HUMAN;tr|A0A087WTI3|A0A087WTI3_HUMAN",563,"F5H5N1","F5H5N1_HUMAN",null,null,"NDUFS7"]
["21.4812","20.4909","19.5989","19.7502","20.8959","19.6529",{"$nulls":3},"mRNA splicing, via spliceosome;protein folding","peptidyl-prolyl cis-trans isomerase activity","catalytic step 2 spliceosome",{"$nulls":3},4,4,4,"31.1","31.1","31.1","18.154",0,"19.44",160800000,11,"0.248997",1,"0.424014","0.628731","sp|Q9H2H8|PPIL3_HUMAN;tr|C9K058|C9K058_HUMAN;tr|B8ZZ77|B8ZZ77_HUMAN;tr|H7BZ14|H7BZ14_HUMAN;tr|F8WC82|F8WC82_HUMAN;tr|C9J4N2|C9J4N2_HUMAN","sp|Q9H2H8|PPIL3_HUMAN;tr|C9K058|C9K058_HUMAN;tr|B8ZZ77|B8ZZ77_HUMAN;tr|H7BZ14|H7BZ14_HUMAN",4430,"Q9H2H8","PPIL3_HUMAN","Peptidyl-prolyl cis-trans isomerase-like 3","PIase","PPIL3"]
["24.3037","22.3454","23.3899","23.5772","22.0862","23.1058",{"$nulls":3},"cellular nitrogen compound metabolic process;dicarboxylic acid metabolic process;excretion;metabolic process;oxidation-reduction process;protein oligomerization","carboxylic acid binding;glycerate dehydrogenase activity;glyoxylate reductase (NADP) activity;hydroxypyruvate reductase activity;NAD binding;NADPH binding;protein homodimerization activity","cytoplasm;cytosol;extracellular exosome;peroxisomal matrix","Glycine, serine and threonine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Pyruvate metabolism",null,null,13,13,13,54,54,54,"35.668",0,"201.87",1550600000,67,"0.231693",1,"0.423278","0.590584","sp|Q9UBQ7|GRHPR_HUMAN;tr|U3KQ56|U3KQ56_HUMAN","sp|Q9UBQ7|GRHPR_HUMAN;tr|U3KQ56|U3KQ56_HUMAN",4970,"Q9UBQ7","GRHPR_HUMAN","Glyoxylate reductase/hydroxypyruvate reductase",null,"GRHPR"]
["19.1432","17.3577","19.5283","18.1755","17.4122","19.1728",{"$nulls":3},"mitotic metaphase plate congression;negative regulation of cell proliferation;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of protein ubiquitination;negative regulation of telomerase activity;negative regulation of telomere maintenance via telomerase;negative regulation of telomere maintenance via telomere lengthening;positive regulation of protein localization to nucleolus;positive regulation of telomeric DNA binding;protein localization to chromosome, telomeric region;protein localization to nucleolus;regulation of protein stability;regulation of telomerase activity;telomere maintenance via telomerase","macromolecular complex binding;telomerase inhibitor activity;telomerase RNA binding","chromosome, telomeric region;condensed chromosome kinetochore;kinetochore;nuclear chromosome;nuclear chromosome, telomeric region;nucleolus;spindle",{"$nulls":3},7,7,7,"29.6","29.6","29.6","37.034",0,"32.559",332680000,23,"0.192843",1,"0.422867","0.502932","sp|Q96BK5|PINX1_HUMAN;tr|E5RJG9|E5RJG9_HUMAN;tr|E5RGR1|E5RGR1_HUMAN;tr|A0A0A6YYK5|A0A0A6YYK5_HUMAN","sp|Q96BK5|PINX1_HUMAN",3805,"Q96BK5","PINX1_HUMAN","PIN2/TERF1-interacting telomerase inhibitor 1",null,"PINX1"]
["23.1338","22.7381","22.8986","22.485","22.2162","22.8039",{"$nulls":5},"integral component of membrane;nuclear membrane",{"$nulls":3},13,13,1,"46.3","46.3",3,"52.406",0,"213.82",1857900000,81,"0.963124",1,"0.421776","2.05668","tr|A0A0A0MSK5|A0A0A0MSK5_HUMAN;sp|Q5JTV8|TOIP1_HUMAN;tr|H0Y4R4|H0Y4R4_HUMAN;tr|H0YD16|H0YD16_HUMAN;tr|H0YDU3|H0YDU3_HUMAN","tr|A0A0A0MSK5|A0A0A0MSK5_HUMAN;sp|Q5JTV8|TOIP1_HUMAN;tr|H0Y4R4|H0Y4R4_HUMAN",2829,"A0A0A0MSK5","A0A0A0MSK5_HUMAN",null,null,"TOR1AIP1"]
["19.4553","16.6593","19.3101","18.9747","16.517","18.6703",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;transcription from RNA polymerase III promoter;transcription initiation from RNA polymerase III promoter;transcription, DNA-templated;tRNA transcription from RNA polymerase III promoter","DNA binding;enzyme activator activity;histone acetyltransferase activity","mitochondrion;nucleoplasm;nucleus;transcription factor TFIIIC complex",{"$nulls":3},16,16,16,"27.1","27.1","27.1","91.981",0,"105.06",555450000,85,"0.129506",1,"0.420836","0.352641","sp|Q9UKN8|TF3C4_HUMAN;tr|F2Z356|F2Z356_HUMAN","sp|Q9UKN8|TF3C4_HUMAN",5096,"Q9UKN8","TF3C4_HUMAN","General transcription factor 3C polypeptide 4",null,"GTF3C4"]
["24.8461","22.6493","24.0042","24.0956","22.1173","24.0251",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","protein homodimerization activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;nucleus;proteasome complex;proteasome regulatory particle;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,12,12,12,"57.1","57.1","57.1","37.025",0,"214.43",1984600000,106,"0.175061",1,"0.420527","0.461758","sp|P51665|PSMD7_HUMAN;tr|H3BNT7|H3BNT7_HUMAN;tr|H3BTM8|H3BTM8_HUMAN;tr|H3BQV2|H3BQV2_HUMAN","sp|P51665|PSMD7_HUMAN;tr|H3BNT7|H3BNT7_HUMAN;tr|H3BTM8|H3BTM8_HUMAN",1750,"P51665","PSMD7_HUMAN","26S proteasome non-ATPase regulatory subunit 7",null,"PSMD7"]
["23.8324","22.5835","23.6382","23.6099","22.0075","23.1776",{"$nulls":3},"cellular aldehyde metabolic process;choline catabolic process;glycine betaine biosynthetic process from choline;lysine catabolic process;sensory perception of sound","aldehyde dehydrogenase (NAD) activity;betaine-aldehyde dehydrogenase activity;L-aminoadipate-semialdehyde dehydrogenase activity","cytosol;extracellular exosome;mitochondrial matrix;mitochondrion;nucleus","Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Fatty acid degradation;Glycerolipid metabolism;Glycine, serine and threonine metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Lysine degradation;Metabolic pathways;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,26,26,26,"62.7","62.7","62.7","58.486",0,"189.92",2346500000,120,"0.27315",1,"0.419696","0.681181","sp|P49419|AL7A1_HUMAN;tr|F8VS02|F8VS02_HUMAN;tr|A0A0J9YWF7|A0A0J9YWF7_HUMAN;tr|H0YHM6|H0YHM6_HUMAN;tr|F8VVF2|F8VVF2_HUMAN;tr|A0A0J9YWM6|A0A0J9YWM6_HUMAN;tr|F8WDY6|F8WDY6_HUMAN;tr|F8WD33|F8WD33_HUMAN;tr|A0A0J9YWK1|A0A0J9YWK1_HUMAN","sp|P49419|AL7A1_HUMAN;tr|F8VS02|F8VS02_HUMAN;tr|A0A0J9YWF7|A0A0J9YWF7_HUMAN",1659,"P49419","AL7A1_HUMAN","Alpha-aminoadipic semialdehyde dehydrogenase","lpha-AASA dehydrogenase","ALDH7A1"]
["22.086","21.2463","22.1987","20.6628","21.7431","21.87",{"$nulls":3},"cell growth;endoplasmic reticulum organization;IRE1-mediated unfolded protein response;posttranslational protein targeting to endoplasmic reticulum membrane;pronephric nephron development;protein targeting to ER;response to interferon-gamma;SRP-dependent cotranslational protein targeting to membrane","ribosome binding","cytosol;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane;rough endoplasmic reticulum","Phagosome;Protein export;Protein processing in endoplasmic reticulum;Vibrio cholerae infection",null,null,8,8,8,"22.1","22.1","22.1","52.264",0,"77.847",561050000,32,"0.357981",1,"0.418362","0.85945","sp|P61619|S61A1_HUMAN;tr|B4DR61|B4DR61_HUMAN;tr|F8W776|F8W776_HUMAN;tr|Q8TC24|Q8TC24_HUMAN;sp|Q9H9S3|S61A2_HUMAN;tr|H7C1Q9|H7C1Q9_HUMAN;tr|C9JXC6|C9JXC6_HUMAN;tr|H7C069|H7C069_HUMAN;tr|A6NK38|A6NK38_HUMAN;tr|F2Z2C7|F2Z2C7_HUMAN;tr|A6NIF9|A6NIF9_HUMAN;tr|C9JJV4|C9JJV4_HUMAN","sp|P61619|S61A1_HUMAN;tr|B4DR61|B4DR61_HUMAN",1935,"P61619","S61A1_HUMAN","Protein transport protein Sec61 subunit alpha isoform 1","ec61 alpha-1","SEC61A1"]
["26.4102","24.7811","25.6779","25.898","24.3176","25.4032",{"$nulls":3},"cellular response to DNA damage stimulus;protein ubiquitination;ubiquitin-dependent protein catabolic process","ATP binding;RNA binding;ubiquitin activating enzyme activity","cytoplasm;cytosol;extracellular exosome;mitochondrion;nucleoplasm;nucleus","Parkinson disease;Ubiquitin mediated proteolysis",null,null,50,50,50,"63.3","63.3","63.3","117.85",0,"323.31",26785000000,634,"0.248896",1,"0.416782","0.628511","sp|P22314|UBA1_HUMAN;tr|Q5JRR6|Q5JRR6_HUMAN;tr|Q5JRR9|Q5JRR9_HUMAN;tr|Q5JRS0|Q5JRS0_HUMAN;tr|Q5JRS2|Q5JRS2_HUMAN;tr|Q5JRS1|Q5JRS1_HUMAN;tr|Q5JRS3|Q5JRS3_HUMAN","sp|P22314|UBA1_HUMAN",1245,"P22314","UBA1_HUMAN","Ubiquitin-like modifier-activating enzyme 1",null,"UBA1"]
["26.5682","23.9912","25.7022","25.6285","23.7335","25.6503",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;membrane;nucleoplasm","Ribosome",null,null,6,6,6,"56.1","56.1","56.1","14.515",0,"154.34",3515500000,65,"0.157906",1,"0.41643","0.421322","sp|P25398|RS12_HUMAN","sp|P25398|RS12_HUMAN",1288,"P25398","RS12_HUMAN","40S ribosomal protein S12",null,"RPS12"]
["20.6239","17.1177","19.017","20.1512","16.6244","18.7366",{"$nulls":5},"cytoplasm;cytosol;ER membrane protein complex;membrane;mitochondrion;nucleus",{"$nulls":3},4,4,4,"31.9","31.9","31.9","23.773",0,"23.806",46501000,7,"0.103778",1,"0.415459","0.288287","sp|O43402|EMC8_HUMAN;tr|M0R1B0|M0R1B0_HUMAN","sp|O43402|EMC8_HUMAN;tr|M0R1B0|M0R1B0_HUMAN",417,"O43402","EMC8_HUMAN","ER membrane protein complex subunit 8",null,"EMC8"]
["22.0675","19.9129","21.4887","20.8835","19.7003","21.6432",{"$nulls":3},"cell division;Golgi disassembly;histone H3-S10 phosphorylation;histone H3-T3 phosphorylation;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;protein autophosphorylation;protein phosphorylation;regulation of cell shape","ATP binding;histone kinase activity (H3-S10 specific);histone kinase activity (H3-T3 specific);nucleosomal histone binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity","cytosol;Golgi stack;nucleolus;nucleoplasm;nucleus;spindle",{"$nulls":3},12,12,12,"35.4","35.4","35.4","45.476",0,"109.75",520080000,60,"0.184294",1,"0.414006","0.483228","sp|Q99986|VRK1_HUMAN;tr|H0YJ50|H0YJ50_HUMAN;tr|H0YJJ9|H0YJJ9_HUMAN;tr|H0YJF7|H0YJF7_HUMAN","sp|Q99986|VRK1_HUMAN;tr|H0YJ50|H0YJ50_HUMAN",4123,"Q99986","VRK1_HUMAN","Serine/threonine-protein kinase VRK1",null,"VRK1"]
["23.4736","21.5761","22.7222","23.1697","20.8361","22.5259",{"$nulls":3},"actin cytoskeleton organization;activation of GTPase activity;cell chemotaxis;G-protein coupled receptor signaling pathway;neutrophil degranulation;platelet activation;positive regulation of cell proliferation;positive regulation of protein localization to plasma membrane;positive regulation of transcription, DNA-templated;Rac protein signal transduction;regulation of ruffle assembly;regulation of small GTPase mediated signal transduction;Rho protein signal transduction","GTP binding;GTPase activity","cytosol;endoplasmic reticulum membrane;extracellular exosome;focal adhesion;plasma membrane;secretory granule membrane","Bacterial invasion of epithelial cells;Salmonella infection;Shigellosis",null,null,7,7,7,"44.5","44.5","44.5","21.308",0,"76.177",667120000,50,"0.176679",1,"0.41339","0.465535","sp|P84095|RHOG_HUMAN","sp|P84095|RHOG_HUMAN",2098,"P84095","RHOG_HUMAN","Rho-related GTP-binding protein RhoG",null,"RHOG"]
["22.419","21.628","22.7082","21.9269","21.2477","22.3408",{"$nulls":3},"RNA phosphodiester bond hydrolysis, endonucleolytic","endoribonuclease activity;single-stranded RNA binding;zinc ion binding","mitochondrial matrix",{"$nulls":3},8,8,8,"35.1","35.1","35.1","32.805",0,"54.705",578680000,44,"0.383222",1,"0.413264","0.911089","sp|Q53H82|LACB2_HUMAN","sp|Q53H82|LACB2_HUMAN",2782,"Q53H82","LACB2_HUMAN","Endoribonuclease LACTB2 {ECO:0000303|PubMed:26826708}",null,"LACTB2"]
["17.992","16.9257","16.8606","17.0185","16.677","16.8492",{"$nulls":3},"autophagosome maturation;endosome to lysosome transport;intracellular protein transport;regulation of SNARE complex assembly;regulation of vacuole fusion, non-autophagic;vacuole organization","actin binding;actin filament binding","autophagosome;axon;clathrin-coated vesicle;early endosome;HOPS complex;late endosome;late endosome membrane;lysosomal membrane;lysosome;neuronal cell body;recycling endosome",{"$nulls":3},2,2,2,"3.6","3.6","3.6","94.693",0,"7.4415",64787000,4,"0.468748",1,"0.411207","1.08276","sp|Q9H269|VPS16_HUMAN;tr|Q5JUA9|Q5JUA9_HUMAN","sp|Q9H269|VPS16_HUMAN;tr|Q5JUA9|Q5JUA9_HUMAN",4423,"Q9H269","VPS16_HUMAN","Vacuolar protein sorting-associated protein 16 homolog","VPS16","VPS16"]
["21.2223","18.8636","18.5246","20.8802","18.1574","18.3416",{"$nulls":3},"cell growth;cell projection organization;cellular iron ion homeostasis;centrosome localization;iron-sulfur cluster assembly;negative regulation of centrosome duplication;protein localization to cell cortex","4 iron, 4 sulfur cluster binding;ATP binding;iron-sulfur cluster binding;metal ion binding;nucleotide binding","centriole;cilium;cytosol;extracellular exosome;nucleus;plasma membrane",{"$nulls":3},3,3,3,"16.9","16.9","16.9","34.534",0,"20.152",109360000,13,"0.122806",1,"0.410468","0.336092","sp|P53384|NUBP1_HUMAN;tr|I3L531|I3L531_HUMAN","sp|P53384|NUBP1_HUMAN;tr|I3L531|I3L531_HUMAN",1795,"P53384","NUBP1_HUMAN","Cytosolic Fe-S cluster assembly factor NUBP1 {ECO:0000255|HAMAP-Rule:MF_03038}",null,"NUBP1"]
["18.4182","17.8064","19.3763","18.7105","16.837","18.8244",{"$nulls":3},"N-acetylneuraminate metabolic process","N-acylneuraminate cytidylyltransferase activity","membrane;nucleoplasm;nucleus","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,6,6,6,"21.4","21.4","21.4","48.379",0,"24.027",97603000,20,"0.199728",1,"0.409684","0.518686","sp|Q8NFW8|NEUA_HUMAN;tr|F5H296|F5H296_HUMAN;tr|F5GYM0|F5GYM0_HUMAN","sp|Q8NFW8|NEUA_HUMAN",3511,"Q8NFW8","NEUA_HUMAN","N-acylneuraminate cytidylyltransferase",null,"CMAS"]
["18.6512","18.1641","19.1703","19.0459","18.0889","17.6239",{"$nulls":3},"generation of precursor metabolites and energy;mitochondrion organization;positive regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter","core promoter sequence-specific DNA binding;protein homodimerization activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytosol;extracellular exosome;nucleoplasm;nucleus","Apelin signaling pathway;Huntington disease",null,null,4,4,4,"8.5","8.5","8.5","53.54",0,"7.7541",123520000,12,"0.330568",1,"0.409013","0.802715","sp|Q16656|NRF1_HUMAN;tr|C9JP85|C9JP85_HUMAN","sp|Q16656|NRF1_HUMAN;tr|C9JP85|C9JP85_HUMAN",2685,"Q16656","NRF1_HUMAN","Nuclear respiratory factor 1","RF-1","NRF1"]
["20.6782","18.5083","21.1039","20.8854","17.9488","20.2299",{"$nulls":3},"cellular response to DNA damage stimulus;DNA ligation involved in DNA repair;double-strand break repair via nonhomologous end joining","identical protein binding;protein complex scaffold activity;protein homodimerization activity","extracellular exosome;nonhomologous end joining complex;nucleus;site of double-strand break",{"$nulls":3},7,7,7,"47.5","47.5","47.5","21.639",0,"27.106",185080000,18,"0.124746",1,"0.408787","0.340899","sp|Q9BUH6|PAXX_HUMAN","sp|Q9BUH6|PAXX_HUMAN",4225,"Q9BUH6","PAXX_HUMAN","Protein PAXX {ECO:0000305}",null,"PAXX"]
["26.6503","25.7162","26.1028","25.5372","25.4808","26.233",{"$nulls":3},"translation","structural constituent of ribosome","cytosol;endoplasmic reticulum;nucleolus;ribosome",{"$nulls":3},7,7,7,"40.2","40.2","40.2","18.756",0,"69.658",5360100000,107,"0.486542",1,"0.406101","1.11799","tr|G3V203|G3V203_HUMAN;sp|Q07020|RL18_HUMAN;tr|J3QQ67|J3QQ67_HUMAN;tr|H0YHA7|H0YHA7_HUMAN;tr|F8VYV2|F8VYV2_HUMAN;tr|A0A075B7A0|A0A075B7A0_HUMAN;tr|F8VUA6|F8VUA6_HUMAN;tr|F8VXR6|F8VXR6_HUMAN","tr|G3V203|G3V203_HUMAN;sp|Q07020|RL18_HUMAN;tr|J3QQ67|J3QQ67_HUMAN;tr|H0YHA7|H0YHA7_HUMAN;tr|F8VYV2|F8VYV2_HUMAN;tr|A0A075B7A0|A0A075B7A0_HUMAN;tr|F8VUA6|F8VUA6_HUMAN",2211,"G3V203","G3V203_HUMAN"]
["22.285","19.8188","21.4463","20.8265","20.3616","21.1458",{"$nulls":3},"nucleobase-containing compound metabolic process;nucleotide metabolic process","3'-5' exonuclease activity;3'-5'-exoribonuclease activity;nucleic acid binding","focal adhesion;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;nucleolus;nucleus","Ribosome biogenesis in eukaryotes",null,null,8,8,8,"48.9","48.9","48.9","26.832",0,"62.315",269890000,19,"0.206516",1,"0.405359","0.534123","sp|Q9Y3B8|ORN_HUMAN;tr|F5GYG5|F5GYG5_HUMAN;tr|H0YG54|H0YG54_HUMAN;tr|H0YGR4|H0YGR4_HUMAN;tr|F5H784|F5H784_HUMAN;tr|Q9BTR4|Q9BTR4_HUMAN;tr|F5H6P8|F5H6P8_HUMAN;tr|H0YG37|H0YG37_HUMAN;tr|H0YF66|H0YF66_HUMAN;tr|F5H7P1|F5H7P1_HUMAN","sp|Q9Y3B8|ORN_HUMAN;tr|F5GYG5|F5GYG5_HUMAN;tr|H0YG54|H0YG54_HUMAN;tr|H0YGR4|H0YGR4_HUMAN",5285,"Q9Y3B8","ORN_HUMAN","Oligoribonuclease, mitochondrial",null,"REXO2"]
["22.131","20.5736","21.5251","21.7567","20.3027","20.955",{"$nulls":3},"alpha-linolenic acid metabolic process;fatty acid elongation, monounsaturated fatty acid;fatty acid elongation, polyunsaturated fatty acid;fatty acid elongation, saturated fatty acid;linoleic acid metabolic process;long-chain fatty-acyl-CoA biosynthetic process;sphingolipid biosynthetic process;very long-chain fatty acid biosynthetic process","3-oxo-arachidoyl-CoA synthase activity;3-oxo-cerotoyl-CoA synthase activity;3-oxo-lignoceronyl-CoA synthase activity;fatty acid elongase activity;very-long-chain 3-ketoacyl-CoA synthase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane","Biosynthesis of unsaturated fatty acids;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways",null,null,2,2,2,9,9,9,"32.662",0,"12.156",263130000,21,"0.261104",1,"0.405044","0.655133","sp|Q9BW60|ELOV1_HUMAN","sp|Q9BW60|ELOV1_HUMAN",4269,"Q9BW60","ELOV1_HUMAN","Elongation of very long chain fatty acids protein 1 {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000305}",null,"ELOVL1"]
["16.9049","14.409",1,"15.8602","14.2406",1,{"$nulls":3},"negative regulation of type B pancreatic cell proliferation","promoter-specific chromatin binding","microtubule organizing center;nucleoplasm;plasma membrane",{"$nulls":3},2,2,2,"6.6","6.6","6.6","53.695","0.0033924","2.7143",10288000,1,"0.0197338",1,"0.404368","0.0592726","sp|Q9H1Z4|WDR13_HUMAN;tr|A0A087X091|A0A087X091_HUMAN","sp|Q9H1Z4|WDR13_HUMAN;tr|A0A087X091|A0A087X091_HUMAN",4420,"Q9H1Z4","WDR13_HUMAN","WD repeat-containing protein 13",null,"WDR13"]
["22.1972","21.2896","22.2156","21.7242","21.0102","21.7596",{"$nulls":3},"ATP-dependent chromatin remodeling","DNA binding","nucleoplasm;SWI/SNF complex",{"$nulls":3},24,23,22,69,"67.2","65.4","44.77",0,"182.18",2414300000,192,"0.442118",1,"0.402798","1.02976","tr|B4DGM3|B4DGM3_HUMAN;sp|Q969G3|SMCE1_HUMAN;tr|J3QKS7|J3QKS7_HUMAN;tr|K7EMQ8|K7EMQ8_HUMAN;tr|H7C048|H7C048_HUMAN;tr|J3QR61|J3QR61_HUMAN;tr|J3KT85|J3KT85_HUMAN;tr|J3QKX6|J3QKX6_HUMAN","tr|B4DGM3|B4DGM3_HUMAN;sp|Q969G3|SMCE1_HUMAN;tr|J3QKS7|J3QKS7_HUMAN",3757,"B4DGM3","B4DGM3_HUMAN",null,null,"SMARCE1"]
["22.9626","21.2413","22.526","22.3706","20.6498","22.5024",{"$nulls":3},"mRNA 3'-splice site recognition;mRNA processing;mRNA splicing, via spliceosome;RNA splicing;RNA splicing, via transesterification reactions","RNA binding;zinc ion binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;spliceosomal complex","Spliceosome",null,null,20,20,20,"36.7","36.7","36.7","58.848",0,"179.79",1345200000,94,"0.195844",1,"0.4024","0.509813","sp|Q12874|SF3A3_HUMAN","sp|Q12874|SF3A3_HUMAN",2273,"Q12874","SF3A3_HUMAN","Splicing factor 3A subunit 3",null,"SF3A3"]
["24.258","23.8664","23.7036","23.5129","23.3565","23.7529",{"$nulls":3},"mRNA splice site selection","enzyme binding;mRNA binding;RNA binding","nuclear speck;U1 snRNP;U2-type prespliceosome",{"$nulls":3},13,13,1,"34.7","34.7","2.8","46.513",0,"147.77",2724400000,114,"0.935323",1,"0.401893","2.00044","sp|Q9Y383|LC7L2_HUMAN;tr|A0A0A6YYC3|A0A0A6YYC3_HUMAN;tr|V9GZ75|V9GZ75_HUMAN;tr|F8WEU3|F8WEU3_HUMAN","sp|Q9Y383|LC7L2_HUMAN;tr|A0A0A6YYC3|A0A0A6YYC3_HUMAN",5272,"Q9Y383","LC7L2_HUMAN","Putative RNA-binding protein Luc7-like 2",null,"LUC7L2"]
["18.107","16.7975","18.1351","18.202","15.613","18.0245",{"$nulls":3},"cell cycle;cell division;cell proliferation;cerebral cortex development;microtubule cytoskeleton organization",null,"cytoplasm;membrane;microtubule cytoskeleton;microtubule organizing center;midbody;nucleus",{"$nulls":3},7,7,7,"14.2","14.2","14.2","87.793",0,"22.745",119620000,14,"0.158852",1,"0.400019","0.423571","sp|O75410|TACC1_HUMAN;tr|H0YAY0|H0YAY0_HUMAN;tr|E7EVI4|E7EVI4_HUMAN;tr|E7ET87|E7ET87_HUMAN;tr|E5RFM9|E5RFM9_HUMAN;tr|R4GMT7|R4GMT7_HUMAN;tr|B4E3H6|B4E3H6_HUMAN;tr|H0YBT8|H0YBT8_HUMAN;tr|E5RJG6|E5RJG6_HUMAN;tr|E5RJU4|E5RJU4_HUMAN","sp|O75410|TACC1_HUMAN;tr|H0YAY0|H0YAY0_HUMAN;tr|E7EVI4|E7EVI4_HUMAN;tr|E7ET87|E7ET87_HUMAN;tr|E5RFM9|E5RFM9_HUMAN;tr|R4GMT7|R4GMT7_HUMAN",585,"O75410","TACC1_HUMAN","Transforming acidic coiled-coil-containing protein 1",null,"TACC1"]
["22.8999","20.1476","22.2345","22.5845","19.8106","21.6894",{"$nulls":3},"dendrite extension;positive regulation of dendritic spine development","basal RNA polymerase II transcription machinery binding;RNA binding","chromosome;nucleolus",{"$nulls":3},2,2,2,"21.7","21.7","21.7","15.225",0,"18.642",542300000,50,"0.125535",1,"0.399167","0.342851","sp|Q9BRT6|LLPH_HUMAN","sp|Q9BRT6|LLPH_HUMAN",4174,"Q9BRT6","LLPH_HUMAN","Protein LLP homolog",null,"LLPH"]
["19.9861","18.1215","19.9812","19.0649","18.0059","19.8229",{"$nulls":3},"neutrophil degranulation","metal ion binding","extracellular region;ficolin-1-rich granule lumen;tertiary granule lumen",{"$nulls":3},2,2,2,"21.5","21.5","21.5","13.841",0,"6.1798",52130000,11,"0.186891",1,"0.398334","0.489232","sp|P62699|YPEL5_HUMAN","sp|P62699|YPEL5_HUMAN",1985,"P62699","YPEL5_HUMAN","Protein yippee-like 5",null,"YPEL5"]
["25.7349","24.0283","24.3598","24.775","23.9299","24.2236",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;intracellular membrane-bounded organelle;nucleoplasm;nucleus;P-body;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex","Proteasome",null,null,12,12,12,"58.6","58.6","58.6","29.483",0,"264.13",3260800000,104,"0.27663",1,"0.398193","0.688667","sp|P25789|PSA4_HUMAN;tr|H0YMZ1|H0YMZ1_HUMAN;tr|H0YN18|H0YN18_HUMAN;tr|H0YL69|H0YL69_HUMAN;tr|H0YMA1|H0YMA1_HUMAN;tr|H0YKT8|H0YKT8_HUMAN;tr|H0YMI6|H0YMI6_HUMAN;tr|H0YKS0|H0YKS0_HUMAN;tr|H0YLC2|H0YLC2_HUMAN;tr|H0YMV3|H0YMV3_HUMAN;tr|H0YLS6|H0YLS6_HUMAN","sp|P25789|PSA4_HUMAN;tr|H0YMZ1|H0YMZ1_HUMAN;tr|H0YN18|H0YN18_HUMAN;tr|H0YL69|H0YL69_HUMAN;tr|H0YMA1|H0YMA1_HUMAN;tr|H0YKT8|H0YKT8_HUMAN;tr|H0YMI6|H0YMI6_HUMAN;tr|H0YKS0|H0YKS0_HUMAN;tr|H0YLC2|H0YLC2_HUMAN",1298,"P25789","PSA4_HUMAN","Proteasome subunit alpha type-4",null,"PSMA4"]
["19.873","18.2479","19.0339","17.9652","18.4731","19.5258",{"$nulls":3},"3'-phosphoadenosine 5'-phosphosulfate metabolic process;catecholamine metabolic process;steroid metabolic process","aryl sulfotransferase activity","cytosol",{"$nulls":3},10,5,5,"52.2","31.2","31.2","34.196",0,"17.185",91066000,14,"0.237931",1,"0.396946","0.604394","sp|P0DMN0|ST1A4_HUMAN;sp|P0DMM9|ST1A3_HUMAN;tr|A0A0A6YYL2|A0A0A6YYL2_HUMAN;tr|H3BNY7|H3BNY7_HUMAN;tr|H3BPL6|H3BPL6_HUMAN;tr|H3BRT0|H3BRT0_HUMAN","sp|P0DMN0|ST1A4_HUMAN;sp|P0DMM9|ST1A3_HUMAN;tr|A0A0A6YYL2|A0A0A6YYL2_HUMAN",1011,"P0DMN0","ST1A4_HUMAN","Sulfotransferase 1A4","T1A4","SULT1A4"]
["21.2988","20.9369","21.0895","20.2268","20.8943","21.0213",{"$nulls":3},"cell adhesion;cell-matrix adhesion;cellular response to reactive oxygen species;endothelial cell migration;epidermal growth factor receptor signaling pathway;growth hormone receptor signaling pathway;muscle contraction;positive regulation of stress fiber assembly;signal complex assembly;signal transduction;transforming growth factor beta receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway","beta-catenin binding;integrin binding;metal ion binding;neuropilin binding;protein kinase binding;ubiquitin protein ligase binding;vinculin binding","cell cortex;cytosol;focal adhesion;lamellipodium;microtubule associated complex;plasma membrane;stress fiber","Bacterial invasion of epithelial cells;Chemokine signaling pathway;Focal adhesion;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Leukocyte transendothelial migration;Proteoglycans in cancer;Regulation of actin cytoskeleton;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,9,9,9,21,21,21,"64.505",0,"167.04",621570000,61,"0.667679",1,"0.394261","1.47222","sp|P49023|PAXI_HUMAN;tr|F5GZ78|F5GZ78_HUMAN;tr|F5H836|F5H836_HUMAN;tr|H0YIE4|H0YIE4_HUMAN","sp|P49023|PAXI_HUMAN;tr|F5GZ78|F5GZ78_HUMAN",1643,"P49023","PAXI_HUMAN","Paxillin",null,"PXN"]
["21.1238","16.2332","18.6624","18.3244","17.4144","19.0987",{"$nulls":3},"L-methionine salvage from methylthioadenosine","identical protein binding;S-methyl-5-thioribose-1-phosphate isomerase activity","cell projection;cytosol;fibrillar center;nucleoplasm","Cysteine and methionine metabolism;Metabolic pathways",null,null,5,5,5,"17.9","17.9","17.9","39.149",0,"17.168",153840000,8,"0.0942286",1,"0.393974","0.263817","sp|Q9BV20|MTNA_HUMAN","sp|Q9BV20|MTNA_HUMAN",4237,"Q9BV20","MTNA_HUMAN","Methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119}","1Pi {ECO:0000255|HAMAP-Rule:MF_03119};TR-1-P isomerase {ECO:0000255|HAMAP-Rule:MF_03119}","MRI1"]
["19.2404","17.6005","19.3632","19.6222","16.5392","18.8635",{"$nulls":3},"actin polymerization or depolymerization;cell division;cellular protein complex localization;dendritic spine morphogenesis;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component;negative regulation of lymphocyte migration;negative regulation of membrane tubulation;positive regulation of Arp2/3 complex-mediated actin nucleation;positive regulation of clathrin-dependent endocytosis;positive regulation of filopodium assembly;protein complex assembly;regulation of nitric-oxide synthase activity;regulation of protein localization;regulation of transcription, DNA-templated;response to bacterium;spindle localization;transcription, DNA-templated;vesicle budding from membrane;vesicle organization;vesicle transport along actin filament","actin binding;GTPase regulator activity","actin cap;actin cytoskeleton;cytoplasmic vesicle;cytosol;endocytic vesicle membrane;extracellular exosome;lamellipodium;nucleus;plasma membrane","Adherens junction;Bacterial invasion of epithelial cells;Chemokine signaling pathway;Choline metabolism in cancer;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis;Tight junction;Yersinia infection",null,null,8,8,8,"25.1","25.1","25.1","54.826",0,"33.541",184290000,12,"0.133048",1,"0.393014","0.361336","sp|O00401|WASL_HUMAN","sp|O00401|WASL_HUMAN",230,"O00401","WASL_HUMAN","Neural Wiskott-Aldrich syndrome protein",{"$f":"-WASP","v":{"$error":"#NAME?"}},"WASL"]
["18.9325","16.5634","17.5266","18.5512","15.4637","17.8387",{"$nulls":3},"transcription from RNA polymerase II promoter","RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;zinc ion binding","integral component of membrane;membrane;nucleus",{"$nulls":3},8,8,8,"12.1","12.1","12.1","101.34",0,"37.073",341690000,43,"0.122779",1,"0.389605","0.336026","sp|Q6ZNB6|NFXL1_HUMAN","sp|Q6ZNB6|NFXL1_HUMAN",3080,"Q6ZNB6","NFXL1_HUMAN","NF-X1-type zinc finger protein NFXL1",null,"NFXL1"]
["25.6819","24.6367","25.2009","25.0566","24.1595","25.1383",{"$nulls":3},"ATP-dependent chromatin remodeling;cell cycle;CENP-A containing nucleosome assembly;chromatin assembly;chromatin remodeling;DNA replication;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;negative regulation of cell proliferation;negative regulation of G0 to G1 transition;negative regulation of gene expression, epigenetic;regulation of cell cycle;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;response to growth hormone;transcription, DNA-templated","histone binding;histone deacetylase activity;histone deacetylase binding","CAF-1 complex;cytosol;ESC/E(Z) complex;nuclear chromatin;nucleoplasm;nucleus;NuRD complex;NURF complex;protein complex;Sin3 complex","Cellular senescence",null,null,18,18,10,"64.9","64.9","54.1","47.655",0,"323.31",6343400000,270,"0.373849",1,"0.388317","0.891975","sp|Q09028|RBBP4_HUMAN;tr|H0YF10|H0YF10_HUMAN;tr|H0YCT5|H0YCT5_HUMAN;tr|H0YDK2|H0YDK2_HUMAN;tr|H0YEU5|H0YEU5_HUMAN;tr|E9PNS6|E9PNS6_HUMAN;tr|E9PNS2|E9PNS2_HUMAN;tr|E9PIC4|E9PIC4_HUMAN;tr|C9JPP3|C9JPP3_HUMAN;tr|C9JAJ9|C9JAJ9_HUMAN;tr|E9PND5|E9PND5_HUMAN","sp|Q09028|RBBP4_HUMAN",2243,"Q09028","RBBP4_HUMAN","Histone-binding protein RBBP4",null,"RBBP4"]
["26.4261","25.3844","25.666","25.9965","24.7764","25.5417",{"$nulls":3},"glucocorticoid catabolic process;glucocorticoid receptor signaling pathway;intracellular protein transport;membrane depolarization during action potential;membrane organization;negative regulation of dendrite morphogenesis;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;positive regulation of transcription, DNA-templated;regulation of neuron differentiation;regulation of sodium ion transmembrane transporter activity;regulation of sodium ion transport;regulation of synaptic plasticity;substantia nigra development","actin binding;enzyme binding;glucocorticoid receptor binding;identical protein binding;insulin-like growth factor receptor binding;ion channel binding;protein domain specific binding;protein heterodimerization activity;sodium channel regulator activity","cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;intercalated disc;mitochondrion;plasma membrane","Cell cycle;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,17,14,14,65,61,61,"28.218",0,"323.31",8476400000,152,"0.33851",1,"0.38732","0.819229","sp|Q04917|1433F_HUMAN;tr|A2IDB2|A2IDB2_HUMAN;tr|F8WEB6|F8WEB6_HUMAN;tr|A2IDB1|A2IDB1_HUMAN","sp|Q04917|1433F_HUMAN",2190,"Q04917","1433F_HUMAN","14-3-3 protein eta",null,"YWHAH"]
["21.2151","20.4622","20.6577","20.2489","20.4146","20.5132",{"$nulls":3},"bicellular tight junction assembly;calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;epithelial cell morphogenesis;protein heterooligomerization;protein homooligomerization;response to ethanol;response to hypoxia","identical protein binding;structural molecule activity;transmembrane signaling receptor activity","apicolateral plasma membrane;bicellular tight junction;cytoplasm;extracellular exosome;integral component of membrane;integral component of plasma membrane;lateral plasma membrane","Cell adhesion molecules (CAMs);Hepatitis C;Leukocyte transendothelial migration;Tight junction",null,null,3,3,2,"16.8","16.8","9.5","23.318",0,"9.4374",94415000,6,"0.743364",1,"0.38612","1.61991","sp|O15551|CLD3_HUMAN;sp|O95484|CLD9_HUMAN;sp|P56747|CLD6_HUMAN","sp|O15551|CLD3_HUMAN",385,"O15551","CLD3_HUMAN","Claudin-3",null,"CLDN3"]
["23.5283","22.8518","23.3691","23.0054","22.3397","23.2494",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrion;ribosome",{"$nulls":3},9,9,9,"52.3","52.3","52.3","25.65",0,"88.438",1062100000,96,"0.493695",1,"0.384898","1.13212","sp|P82930|RT34_HUMAN;tr|C9JJ19|C9JJ19_HUMAN;tr|A0A087WUZ8|A0A087WUZ8_HUMAN","sp|P82930|RT34_HUMAN;tr|C9JJ19|C9JJ19_HUMAN;tr|A0A087WUZ8|A0A087WUZ8_HUMAN",2083,"P82930","RT34_HUMAN","28S ribosomal protein S34, mitochondrial","34mt;RP-S34","MRPS34"]
["23.1938","22.8495","22.5937","22.6566","22.3518","22.4759",{"$nulls":3},"ATP-dependent chromatin remodeling;beta-catenin-TCF complex assembly;blood coagulation;cellular response to oxidative stress;cellular response to tumor necrosis factor;chromatin organization;chromatin remodeling;circadian regulation of gene expression;embryonic digit morphogenesis;epidermal cell differentiation;eyelid development in camera-type eye;fungiform papilla formation;hair follicle placode formation;histone deacetylation;histone H3 deacetylation;histone H4 deacetylation;methylation-dependent chromatin silencing;negative regulation by host of viral transcription;negative regulation of androgen receptor signaling pathway;negative regulation of apoptotic process;negative regulation of canonical Wnt signaling pathway;negative regulation of cell proliferation;negative regulation of gene expression;negative regulation of insulin secretion;negative regulation of neuron apoptotic process;negative regulation of peptidyl-lysine acetylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;odontogenesis of dentin-containing tooth;positive regulation of cell proliferation;positive regulation of chemokine (C-X-C motif) ligand 2 production;positive regulation of interleukin-1 production;positive regulation of oligodendrocyte differentiation;positive regulation of receptor biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of tumor necrosis factor production;positive regulation of type B pancreatic cell apoptotic process;positive regulation of tyrosine phosphorylation of STAT protein;protein deacetylation;regulation of megakaryocyte differentiation;regulation of signal transduction by p53 class mediator;response to amphetamine;response to caffeine;response to drug;response to hyperoxia;response to lipopolysaccharide;transcription, DNA-templated;viral process","activating transcription factor binding;chromatin binding;core promoter binding;core promoter sequence-specific DNA binding;deacetylase activity;DNA binding transcription factor activity;enzyme binding;histone deacetylase activity;histone deacetylase binding;NAD-dependent histone deacetylase activity (H3-K14 specific);NF-kappaB binding;p53 binding;protein complex binding;protein deacetylase activity;protein N-terminus binding;repressing transcription factor binding;RNA polymerase II repressing transcription factor binding;RNA polymerase II transcription corepressor activity;RNA polymerase II transcription factor binding;transcription factor binding;transcription regulatory region DNA binding;transcription regulatory region sequence-specific DNA binding","chromatin;cytoplasm;cytosol;histone deacetylase complex;neuron projection;nuclear chromatin;nucleoplasm;nucleus;NuRD complex;perinuclear region of cytoplasm;protein complex;Sin3 complex","Alcoholism;Amphetamine addiction;Cell cycle;Chronic myeloid leukemia;Epstein-Barr virus infection;Human papillomavirus infection;Huntington disease;Longevity regulating pathway - multiple species;MicroRNAs in cancer;Notch signaling pathway;Pathways in cancer;Thyroid hormone signaling pathway;Transcriptional misregulation in cancer;Viral carcinogenesis",null,null,16,16,11,"35.3","35.3","24.3","55.102",0,165,2474000000,174,"0.919845",1,"0.384226","1.96928","sp|Q13547|HDAC1_HUMAN;tr|Q5TEE2|Q5TEE2_HUMAN","sp|Q13547|HDAC1_HUMAN;tr|Q5TEE2|Q5TEE2_HUMAN",2378,"Q13547","HDAC1_HUMAN","Histone deacetylase 1","D1","HDAC1"]
["23.3453","21.831","21.3956","23.1195","21.6432","20.6651",{"$nulls":3},"cell adhesion;cell-cell signaling;cell-matrix adhesion;cellular response to interferon-gamma;integrin-mediated signaling pathway;regulation of inflammatory response;signal transduction;stress fiber assembly;transforming growth factor beta receptor signaling pathway;viral process","metal ion binding;RNA binding","cell-cell adherens junction;cytosol;focal adhesion;integral component of plasma membrane;nucleus;phagocytic vesicle;plasma membrane;stress fiber","Focal adhesion",null,null,14,14,14,"43.4","43.4","43.4","61.277",0,"263.06",1123000000,86,"0.153882",1,"0.381376","0.411728","sp|Q15942|ZYX_HUMAN;tr|H0Y2Y8|H0Y2Y8_HUMAN;tr|H7C3D3|H7C3D3_HUMAN;tr|C9IZ41|C9IZ41_HUMAN;tr|H7C3R3|H7C3R3_HUMAN;tr|C9JJK5|C9JJK5_HUMAN","sp|Q15942|ZYX_HUMAN;tr|H0Y2Y8|H0Y2Y8_HUMAN",2655,"Q15942","ZYX_HUMAN","Zyxin",null,"ZYX"]
["19.2427","19.477","18.0235","18.6374","18.4951","18.4672",{"$nulls":3},"ATP hydrolysis coupled proton transport;ATP synthesis coupled proton transport;insulin receptor signaling pathway;ion transmembrane transport;neutrophil degranulation;phagosome acidification;regulation of macroautophagy;toxin transport;transferrin transport;vacuolar acidification;vacuolar proton-transporting V-type ATPase complex assembly","ATPase binding;proton-transporting ATPase activity, rotational mechanism","cytosol;endosome membrane;extracellular exosome;ficolin-1-rich granule membrane;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;lysosomal membrane;melanosome;nuclear speck;phagocytic vesicle membrane;plasma membrane;secretory granule membrane;vacuolar proton-transporting V-type ATPase complex;vacuolar proton-transporting V-type ATPase, V0 domain","Collecting duct acid secretion;Epithelial cell signaling in Helicobacter pylori infection;Human papillomavirus infection;Lysosome;Metabolic pathways;Oxidative phosphorylation;Phagosome;Rheumatoid arthritis;Synaptic vesicle cycle;Tuberculosis;Vibrio cholerae infection",null,null,9,9,8,"15.9","15.9","14.9","96.412",0,"18.119",159590000,21,"0.348648",1,"0.381168","0.840216","sp|Q93050|VPP1_HUMAN;tr|B7Z641|B7Z641_HUMAN;tr|B7Z2A9|B7Z2A9_HUMAN;tr|K7EN36|K7EN36_HUMAN;tr|K7EPG4|K7EPG4_HUMAN;tr|F5H1T6|F5H1T6_HUMAN;tr|K7ELZ6|K7ELZ6_HUMAN;tr|K7EM24|K7EM24_HUMAN;tr|K7EQW2|K7EQW2_HUMAN","sp|Q93050|VPP1_HUMAN;tr|B7Z641|B7Z641_HUMAN;tr|B7Z2A9|B7Z2A9_HUMAN",3752,"Q93050","VPP1_HUMAN","V-type proton ATPase 116 kDa subunit a isoform 1","-ATPase 116 kDa isoform a1","ATP6V0A1"]
["22.8719","21.8328","22.1565","22.1508","21.6257","21.9473",{"$nulls":3},"activation of JUN kinase activity;adaptive immune response;neuron projection morphogenesis;neutrophil degranulation;podosome assembly;Rac protein signal transduction;receptor-mediated endocytosis;ruffle assembly;synapse assembly","actin binding;actin filament binding;cadherin binding;enzyme activator activity;protein C-terminus binding;protein domain specific binding","cell cortex;cell junction;clathrin-coated vesicle membrane;cytoplasm;cytosol;dendrite;early endosome;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;Golgi membrane;lamellipodium;plasma membrane;podosome;postsynaptic density;ruffle;secretory granule lumen;tertiary granule lumen",{"$nulls":3},11,11,11,"34.9","34.9","34.9","48.207",0,"120.15",945280000,69,"0.480293",1,"0.379151","1.10563","sp|Q9UJU6|DBNL_HUMAN;tr|B4DDD6|B4DDD6_HUMAN;tr|H0Y5J4|H0Y5J4_HUMAN;tr|F8WBG8|F8WBG8_HUMAN;tr|F8WC20|F8WC20_HUMAN;tr|F8WBB2|F8WBB2_HUMAN;tr|F8WFE1|F8WFE1_HUMAN;tr|F2Z2V3|F2Z2V3_HUMAN;tr|F8WB73|F8WB73_HUMAN;tr|F8WCK3|F8WCK3_HUMAN;tr|F2Z3E3|F2Z3E3_HUMAN;tr|H7C111|H7C111_HUMAN","sp|Q9UJU6|DBNL_HUMAN;tr|B4DDD6|B4DDD6_HUMAN;tr|H0Y5J4|H0Y5J4_HUMAN",5064,"Q9UJU6","DBNL_HUMAN","Drebrin-like protein",null,"DBNL"]
["22.431","20.6601","21.9891","21.6298","20.4685","21.8472",{"$nulls":3},"cellular response to leukemia inhibitory factor;negative regulation of RNA-directed 5'-3' RNA polymerase activity;nuclear-transcribed mRNA poly(A) tail shortening;regulation of translational initiation;RNA secondary structure unwinding;translational initiation;viral process","ATP binding;ATPase activity;ATP-dependent RNA helicase activity;helicase activity;RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 4F complex;nucleolus;perinuclear region of cytoplasm","RNA transport",null,null,20,9,9,56,"30.5","30.5","46.402",0,"148.37",849030000,60,"0.215272",1,"0.378247","0.553895","sp|Q14240|IF4A2_HUMAN;tr|E7EQG2|E7EQG2_HUMAN;tr|J3KSN7|J3KSN7_HUMAN;tr|E7EMV8|E7EMV8_HUMAN;tr|E9PBH4|E9PBH4_HUMAN;tr|F8WE11|F8WE11_HUMAN;tr|C9JUF0|C9JUF0_HUMAN","sp|Q14240|IF4A2_HUMAN;tr|E7EQG2|E7EQG2_HUMAN",2458,"Q14240","IF4A2_HUMAN","Eukaryotic initiation factor 4A-II","IF4A-II;IF-4A-II","EIF4A2"]
["23.9835","22.8653","23.549","23.5252","22.3047","23.4343",{"$nulls":3},"IRE1-mediated unfolded protein response;small GTPase mediated signal transduction","GTP binding;signal recognition particle binding","cytoplasm;cytoplasmic microtubule;endoplasmic reticulum membrane;integral component of membrane;membrane;signal recognition particle receptor complex","Protein export",null,null,14,14,14,"63.1","63.1","63.1","29.702",0,"116.49",2939600000,178,"0.301221",1,"0.377902","0.741102","sp|Q9Y5M8|SRPRB_HUMAN;tr|H7C4H2|H7C4H2_HUMAN;tr|C9J5Z8|C9J5Z8_HUMAN","sp|Q9Y5M8|SRPRB_HUMAN;tr|H7C4H2|H7C4H2_HUMAN",5359,"Q9Y5M8","SRPRB_HUMAN","Signal recognition particle receptor subunit beta","R-beta","SRPRB"]
["16.2586","15.7247","16.2506","15.0452","16.0291","16.0313",{"$nulls":3},"cell cycle;cellular response to DNA damage stimulus;covalent chromatin modification;intracellular protein transport;intracellular signal transduction;protein phosphorylation;regulation of chromatin assembly or disassembly","ATP binding;protein serine/threonine kinase activity","nucleus",{"$nulls":3},3,1,1,"5.7","2.6","2.6","86.699","0.0010099","3.7061",17076000,3,"0.431626",1,"0.376108","1.00878","sp|Q9UKI8|TLK1_HUMAN;tr|F8W7X8|F8W7X8_HUMAN;tr|B3KRP1|B3KRP1_HUMAN","sp|Q9UKI8|TLK1_HUMAN",5089,"Q9UKI8","TLK1_HUMAN","Serine/threonine-protein kinase tousled-like 1",null,"TLK1"]
["24.1077","22.4678","23.1234","22.993","22.4522","23.1294",{"$nulls":3},"cellular protein modification process","ATP binding;catalytic activity",{"$nulls":4},27,27,27,"57.1","57.1","57.1","74.403",0,"304.41",2818600000,148,"0.29194",1,"0.374758","0.721403","sp|Q14166|TTL12_HUMAN;tr|V9GY16|V9GY16_HUMAN","sp|Q14166|TTL12_HUMAN",2447,"Q14166","TTL12_HUMAN","Tubulin--tyrosine ligase-like protein 12",null,"TTLL12"]
["25.8741","25.0783","25.551","25.5658","24.5813","25.2346",{"$nulls":3},"cell redox homeostasis;chaperone-mediated protein folding;protein folding;protein secretion;response to endoplasmic reticulum stress","peptide disulfide oxidoreductase activity;protein disulfide isomerase activity;RNA binding","cell surface;endoplasmic reticulum;endoplasmic reticulum lumen;extracellular space;melanosome","Protein processing in endoplasmic reticulum;Thyroid hormone synthesis;Vibrio cholerae infection",null,null,45,45,45,"62.9","62.9","62.9","72.932",0,"323.31",16828000000,509,"0.432287",1,"0.373917","1.01011","sp|P13667|PDIA4_HUMAN;tr|C9JMN9|C9JMN9_HUMAN","sp|P13667|PDIA4_HUMAN",1084,"P13667","PDIA4_HUMAN","Protein disulfide-isomerase A4",null,"PDIA4"]
["24.6504","23.2994","23.5857","23.9105","22.9821","23.5267",{"$nulls":3},"adenine salvage;central nervous system neuron development;cerebral cortex neuron differentiation;cytolysis;dendrite morphogenesis;dopamine metabolic process;GMP catabolic process;grooming behavior;guanine salvage;hypoxanthine metabolic process;hypoxanthine salvage;IMP metabolic process;IMP salvage;locomotory behavior;lymphocyte proliferation;positive regulation of dopamine metabolic process;protein homotetramerization;purine nucleotide biosynthetic process;purine ribonucleoside salvage;purine-containing compound salvage;response to amphetamine;striatum development","guanine phosphoribosyltransferase activity;hypoxanthine phosphoribosyltransferase activity;identical protein binding;magnesium ion binding;nucleotide binding;protein homodimerization activity","cytoplasm;cytosol;extracellular exosome","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism",null,null,11,11,11,"69.7","69.7","69.7","24.579",0,"205.61",1584200000,68,"0.308786",1,"0.372035","0.757079","sp|P00492|HPRT_HUMAN","sp|P00492|HPRT_HUMAN",829,"P00492","HPRT_HUMAN","Hypoxanthine-guanine phosphoribosyltransferase","GPRT;GPRTase","HPRT1"]
["27.0124","25.671","26.6258","26.5026","25.3003","26.3909",{"$nulls":3},"activation of innate immune response;brain development;cellular hyperosmotic salinity response;cellular response to gamma radiation;cellular response to X-ray;DNA ligation;DNA recombination;double-strand break repair via classical nonhomologous end joining;double-strand break repair via nonhomologous end joining;establishment of integrated proviral latency;innate immune response;negative regulation of transcription, DNA-templated;neutrophil degranulation;positive regulation of protein kinase activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;protein heterotetramerization;regulation of smooth muscle cell proliferation;telomere maintenance;transcription, DNA-templated","5'-deoxyribose-5-phosphate lyase activity;ATP binding;ATP-dependent DNA helicase activity;cyclin binding;damaged DNA binding;DNA binding;double-stranded DNA binding;macromolecular complex binding;protein C-terminus binding;RNA binding;telomeric DNA binding;transcription regulatory region DNA binding","cytosol;extracellular region;ficolin-1-rich granule lumen;Ku70:Ku80 complex;membrane;nonhomologous end joining complex;nuclear chromosome, telomeric region;nuclear telomere cap complex;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;secretory granule lumen;transcription factor complex","Non-homologous end-joining",null,null,39,39,39,"63.9","63.9","63.9","69.842",0,"323.31",36243000000,1128,"0.268977",1,"0.371828","0.672181","sp|P12956|XRCC6_HUMAN;tr|B1AHC9|B1AHC9_HUMAN","sp|P12956|XRCC6_HUMAN;tr|B1AHC9|B1AHC9_HUMAN",1073,"P12956","XRCC6_HUMAN","X-ray repair cross-complementing protein 6",null,"XRCC6"]
["18.8503","17.5074","19.4187","19.0023","16.8836","18.7773",{"$nulls":5},"cytoskeleton;cytosol;filopodium;membrane;nucleoplasm;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},8,8,8,"13.2","13.2","13.2","73.91",0,"33.797",168640000,23,"0.158267",1,"0.371065","0.422179","sp|Q9H4E7|DEFI6_HUMAN;tr|G3V2J3|G3V2J3_HUMAN;tr|G3V333|G3V333_HUMAN;sp|Q6TDU7|CASC1_HUMAN;tr|F8W8F9|F8W8F9_HUMAN","sp|Q9H4E7|DEFI6_HUMAN",4464,"Q9H4E7","DEFI6_HUMAN","Differentially expressed in FDCP 6 homolog","EF-6","DEF6"]
["21.4569","19.6611","20.0518","21.4775","18.5372","20.0461",{"$nulls":3},"catabolic process;epithelial cell differentiation","hydrolase activity, acting on ester bonds;zinc ion binding","extracellular exosome",{"$nulls":3},12,12,12,"42.4","42.4","42.4","39.017",0,"61.062",314770000,29,"0.13512",1,"0.369675","0.366404","sp|Q96BW5|PTER_HUMAN;tr|A0A0A0MSI3|A0A0A0MSI3_HUMAN","sp|Q96BW5|PTER_HUMAN;tr|A0A0A0MSI3|A0A0A0MSI3_HUMAN",3812,"Q96BW5","PTER_HUMAN","Phosphotriesterase-related protein",null,"PTER"]
["22.5932","21.8326","22.505","22.1449","21.6913","21.9866",{"$nulls":3},"in utero embryonic development;nucleotide-excision repair, DNA damage recognition;post-translational protein modification;protein deneddylation;response to light stimulus;signal transduction;transcription-coupled nucleotide-excision repair;ubiquitin-dependent protein catabolic process",null,"COP9 signalosome;cytoplasm;cytosol;nucleoplasm;nucleus",{"$nulls":3},10,10,10,"35.2","35.2","35.2","47.873",0,"207.29",1074800000,61,"0.602564",1,"0.369307","1.34538","sp|Q9UNS2|CSN3_HUMAN;tr|H7C3P9|H7C3P9_HUMAN;tr|C9JLV5|C9JLV5_HUMAN;tr|J3QKR0|J3QKR0_HUMAN;tr|K7ES36|K7ES36_HUMAN;tr|J3QL22|J3QL22_HUMAN;tr|J3QS85|J3QS85_HUMAN;tr|J3KTQ1|J3KTQ1_HUMAN","sp|Q9UNS2|CSN3_HUMAN;tr|H7C3P9|H7C3P9_HUMAN",5162,"Q9UNS2","CSN3_HUMAN","COP9 signalosome complex subunit 3","GN3;ignalosome subunit 3","COPS3"]
["22.2988","20.5028","20.7402","21.7788","20.0661","20.5907",{"$nulls":3},"NAD biosynthesis via nicotinamide riboside salvage pathway;neutrophil degranulation;nicotinate nucleotide salvage;response to oxidative stress","ligase activity;nicotinate phosphoribosyltransferase activity;nicotinate-nucleotide diphosphorylase (carboxylating) activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region","Metabolic pathways;Nicotinate and nicotinamide metabolism",null,null,15,15,15,"46.7","46.7","46.7","57.578",0,"191.93",974040000,48,"0.185818",1,"0.36877","0.486751","sp|Q6XQN6|PNCB_HUMAN;tr|G5E977|G5E977_HUMAN;tr|C9J8U2|C9J8U2_HUMAN;tr|A0A087WUT5|A0A087WUT5_HUMAN;tr|H0YDA6|H0YDA6_HUMAN;tr|H0YF31|H0YF31_HUMAN","sp|Q6XQN6|PNCB_HUMAN;tr|G5E977|G5E977_HUMAN;tr|C9J8U2|C9J8U2_HUMAN",3070,"Q6XQN6","PNCB_HUMAN","Nicotinate phosphoribosyltransferase","APRTase","NAPRT"]
["24.6628","23.3531","24.208","24.187","22.8931","24.039",{"$nulls":3},"cellular response to hypoxia;ER to Golgi vesicle-mediated transport;IRE1-mediated unfolded protein response;negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway;negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;receptor-mediated endocytosis;response to endoplasmic reticulum stress;response to ischemia","ATP binding;chaperone binding","endocytic vesicle lumen;endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;extracellular exosome;extracellular region;focal adhesion;membrane;smooth endoplasmic reticulum","Protein processing in endoplasmic reticulum",null,null,43,43,43,"53.9","53.9","53.9","111.33",0,"323.31",9158200000,459,"0.261797",1,"0.368281","0.656636","sp|Q9Y4L1|HYOU1_HUMAN;tr|A0A087X054|A0A087X054_HUMAN;tr|E9PJ21|E9PJ21_HUMAN;tr|A0A087WWI4|A0A087WWI4_HUMAN;tr|K7EQK2|K7EQK2_HUMAN;tr|J3KTF1|J3KTF1_HUMAN;tr|J3QL06|J3QL06_HUMAN;tr|Q9BST8|Q9BST8_HUMAN;tr|J3QQH7|J3QQH7_HUMAN;tr|J3QLE9|J3QLE9_HUMAN;tr|A0A087X214|A0A087X214_HUMAN;tr|A0A087WW13|A0A087WW13_HUMAN;sp|Q9BXT5|TEX15_HUMAN","sp|Q9Y4L1|HYOU1_HUMAN;tr|A0A087X054|A0A087X054_HUMAN;tr|E9PJ21|E9PJ21_HUMAN;tr|A0A087WWI4|A0A087WWI4_HUMAN;tr|K7EQK2|K7EQK2_HUMAN",5329,"Q9Y4L1","HYOU1_HUMAN","Hypoxia up-regulated protein 1",null,"HYOU1"]
["22.2563","22.7315","21.4859","22.0494","21.7287","21.5933",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;activation of signaling protein activity involved in unfolded protein response;apoptotic mitochondrial changes;apoptotic process;apoptotic process involved in blood vessel morphogenesis;apoptotic process involved in embryonic digit morphogenesis;apoptotic signaling pathway;B cell apoptotic process;B cell homeostasis;B cell homeostatic proliferation;B cell negative selection;B cell receptor apoptotic signaling pathway;blood vessel remodeling;cellular response to UV;cerebral cortex development;development of secondary sexual characteristics;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;ectopic germ cell programmed cell death;endoplasmic reticulum calcium ion homeostasis;establishment or maintenance of transmembrane electrochemical gradient;extrinsic apoptotic signaling pathway;extrinsic apoptotic signaling pathway in absence of ligand;extrinsic apoptotic signaling pathway via death domain receptors;fertilization;germ cell development;glycosphingolipid metabolic process;homeostasis of number of cells within a tissue;hypothalamus development;intrinsic apoptotic signaling pathway;intrinsic apoptotic signaling pathway by p53 class mediator;intrinsic apoptotic signaling pathway in response to DNA damage;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;kidney development;mitochondrial fragmentation involved in apoptotic process;mitochondrial fusion;mitochondrion morphogenesis;myeloid cell homeostasis;negative regulation of apoptotic signaling pathway;negative regulation of endoplasmic reticulum calcium ion concentration;negative regulation of fibroblast proliferation;negative regulation of neuron apoptotic process;negative regulation of peptidyl-serine phosphorylation;negative regulation of protein binding;neuron apoptotic process;neuron migration;odontogenesis of dentin-containing tooth;ovarian follicle development;positive regulation of apoptotic DNA fragmentation;positive regulation of apoptotic process;positive regulation of apoptotic process involved in mammary gland involution;positive regulation of B cell apoptotic process;positive regulation of developmental pigmentation;positive regulation of endoplasmic reticulum unfolded protein response;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of IRE1-mediated unfolded protein response;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of neuron apoptotic process;positive regulation of protein oligomerization;positive regulation of release of cytochrome c from mitochondria;positive regulation of release of sequestered calcium ion into cytosol;post-embryonic camera-type eye morphogenesis;protein homooligomerization;protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein oligomerization;regulation of apoptotic process;regulation of mammary gland epithelial cell proliferation;regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;regulation of mitochondrial membrane potential;regulation of nitrogen utilization;regulation of protein heterodimerization activity;regulation of protein homodimerization activity;release of cytochrome c from mitochondria;release of matrix enzymes from mitochondria;response to axon injury;response to gamma radiation;response to salt stress;response to toxic substance;retina development in camera-type eye;retinal cell programmed cell death;Sertoli cell proliferation;spermatid differentiation;T cell homeostatic proliferation;thymocyte apoptotic process;transcription initiation from RNA polymerase II promoter;vagina development;viral process","BH3 domain binding;channel activity;chaperone binding;Hsp70 protein binding;identical protein binding;lipid binding;protein heterodimerization activity;protein homodimerization activity","BAX complex;Bcl-2 family protein complex;cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;membrane;mitochondrial outer membrane;mitochondrial permeability transition pore complex;mitochondrion;nuclear envelope;nucleus;pore complex","AGE-RAGE signaling pathway in diabetic complications;Amyotrophic lateral sclerosis (ALS);Apoptosis;Apoptosis - multiple species;Basal cell carcinoma;Breast cancer;Chronic myeloid leukemia;Colorectal cancer;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;Epstein-Barr virus infection;Gastric cancer;Glioma;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Longevity regulating pathway;Measles;Melanoma;Necroptosis;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Non-small cell lung cancer;p53 signaling pathway;Pancreatic cancer;Pathways in cancer;Platinum drug resistance;Prion diseases;Protein processing in endoplasmic reticulum;Small cell lung cancer;Sphingolipid signaling pathway;Thyroid cancer;Transcriptional misregulation in cancer;Tuberculosis;Viral carcinogenesis",null,null,6,6,6,"36.5","36.5","36.5","21.184",0,"27.894",338270000,25,"0.401801",1,"0.367463","0.948777","sp|Q07812|BAX_HUMAN;tr|K4JQN1|K4JQN1_HUMAN;tr|I6LPK7|I6LPK7_HUMAN","sp|Q07812|BAX_HUMAN;tr|K4JQN1|K4JQN1_HUMAN",2216,"Q07812","BAX_HUMAN","Apoptosis regulator BAX",null,"BAX"]
["20.0951","19.6718","18.855","19.1336","19.1598","19.2311",{"$nulls":4},"RNA binding",{"$nulls":4},6,6,6,"19.1","19.1","19.1","50.559",0,"26.481",96617000,17,"0.428197",1,"0.365796","1.00191","sp|Q7L4I2|RSRC2_HUMAN;tr|E9PI52|E9PI52_HUMAN;tr|H0YGP9|H0YGP9_HUMAN;tr|E1B6W4|E1B6W4_HUMAN","sp|Q7L4I2|RSRC2_HUMAN",3123,"Q7L4I2","RSRC2_HUMAN","Arginine/serine-rich coiled-coil protein 2",null,"RSRC2"]
["27.2631","25.6774","26.2937","26.9079","25.2571","25.9731",{"$nulls":3},"blood coagulation;negative regulation of apoptotic process;negative regulation of coagulation;platelet degranulation;response to organic substance;signal transduction","calcium ion binding;calcium-dependent phospholipid binding;phospholipase inhibitor activity;phospholipid binding","cytoplasm;cytosol;endothelial microparticle;external side of plasma membrane;extracellular exosome;extracellular region;focal adhesion;intracellular;membrane",{"$nulls":3},23,23,23,"76.2","76.2","76.2","35.936",0,"323.31",17859000000,318,"0.2135",1,"0.365358","0.549905","sp|P08758|ANXA5_HUMAN;tr|D6RBL5|D6RBL5_HUMAN;tr|D6RBE9|D6RBE9_HUMAN;tr|E9PHT9|E9PHT9_HUMAN;tr|D6RCN3|D6RCN3_HUMAN","sp|P08758|ANXA5_HUMAN;tr|D6RBL5|D6RBL5_HUMAN;tr|D6RBE9|D6RBE9_HUMAN;tr|E9PHT9|E9PHT9_HUMAN",975,"P08758","ANXA5_HUMAN","Annexin A5",null,"ANXA5"]
["23.7631","22.4888","23.3769","22.9982","22.3579","23.1775",{"$nulls":3},"G2/M transition of mitotic cell cycle;protein demethylation","cadherin binding;protein C-terminal methylesterase activity;protein kinase binding;protein phosphatase 2A binding;protein phosphatase binding;protein phosphatase inhibitor activity;protein phosphatase regulator activity","nucleoplasm",{"$nulls":3},15,15,15,"47.2","47.2","47.2","42.315",0,"323.31",1575100000,110,"0.333086",1,"0.365095","0.807958","sp|Q9Y570|PPME1_HUMAN","sp|Q9Y570|PPME1_HUMAN",5345,"Q9Y570","PPME1_HUMAN","Protein phosphatase methylesterase 1","ME-1","PPME1"]
["23.9336","21.4121","22.3509","23.0508","21.065","22.4929",{"$nulls":3},"apoptotic process;negative regulation of cell proliferation;positive regulation of aminoacyl-tRNA ligase activity;positive regulation of neuron death;positive regulation of protein ubiquitination;protein complex assembly;tRNA aminoacylation for protein translation;Type II pneumocyte differentiation","protein complex scaffold activity","aminoacyl-tRNA synthetase multienzyme complex;cytosol;membrane;nucleus",{"$nulls":3},9,9,9,"45.6","45.6","45.6","35.348",0,"316.45",2219200000,138,"0.142411",1,"0.362591","0.384135","sp|Q13155|AIMP2_HUMAN;tr|A8MU58|A8MU58_HUMAN;tr|F8W950|F8W950_HUMAN","sp|Q13155|AIMP2_HUMAN;tr|A8MU58|A8MU58_HUMAN;tr|F8W950|F8W950_HUMAN",2317,"Q13155","AIMP2_HUMAN","Aminoacyl tRNA synthase complex-interacting multifunctional protein 2",null,"AIMP2"]
["22.5194","20.7163","21.5806","22.5746","19.7276","21.4318",{"$nulls":3},"actin cytoskeleton organization;caveola assembly;caveolin-mediated endocytosis;cell projection morphogenesis;membrane organization;negative regulation of endocytosis;plasma membrane tubulation;protein localization to endosome;regulation of endocytosis","cadherin binding;cytoskeletal protein binding;identical protein binding;phosphatidic acid binding;transporter activity","caveola;cell-cell junction;cytoplasm;cytoplasmic vesicle membrane;cytoskeleton;cytosol;early endosome;extracellular exosome;extrinsic component of membrane;focal adhesion;intracellular membrane-bounded organelle;nuclear speck;plasma membrane;recycling endosome membrane;ruffle membrane",{"$nulls":3},13,13,13,"38.1","38.1","38.1","55.738",0,"108.53",897340000,64,"0.136234",1,"0.360783","0.369123","sp|Q9UNF0|PACN2_HUMAN;tr|B0QYG7|B0QYG7_HUMAN;tr|B0QYG8|B0QYG8_HUMAN;tr|H0Y923|H0Y923_HUMAN","sp|Q9UNF0|PACN2_HUMAN",5150,"Q9UNF0","PACN2_HUMAN","Protein kinase C and casein kinase substrate in neurons protein 2",null,"PACSIN2"]
[1,"17.5946","16.063",1,"16.4884","16.0902",{"$nulls":3},"bone resorption;neutrophil degranulation;peptidyl-cysteine methylation;positive regulation of regulated secretory pathway;protein transport","GTP binding;GTPase activity;GTP-dependent protein binding;myosin V binding","azurophil granule membrane;cytoplasmic microtubule;extracellular exosome;mitochondrion;plasma membrane;secretory vesicle;transport vesicle;zymogen granule","Pancreatic secretion",null,null,5,4,4,"26.5","22.8","22.8","24.267",0,"7.692",36704000,6,"0.0162297",1,"0.359646","0.0489319","sp|O95716|RAB3D_HUMAN","sp|O95716|RAB3D_HUMAN",781,"O95716","RAB3D_HUMAN","Ras-related protein Rab-3D",null,"RAB3D"]
["23.316","21.2952","21.7715","22.7966","20.9998","21.5125",{"$nulls":3},"cell cycle;cell division;chromosome segregation;neutrophil degranulation;small GTPase mediated signal transduction","alpha-tubulin binding;beta-tubulin binding;GTP binding;GTPase activity","azurophil granule membrane;cytoplasm;extracellular exosome;ficolin-1-rich granule membrane;late endosome membrane;lysosomal membrane;membrane;midbody;plasma membrane;spindle midzone",{"$nulls":3},9,9,3,"44.1","44.1","18.3","21.416",0,"55.724",456880000,29,"0.166383",1,"0.357934","0.441396","sp|Q96BM9|ARL8A_HUMAN;tr|A0A087X2J2|A0A087X2J2_HUMAN","sp|Q96BM9|ARL8A_HUMAN",3806,"Q96BM9","ARL8A_HUMAN","ADP-ribosylation factor-like protein 8A",null,"ARL8A"]
["25.8258","24.3627","25.4944","25.8463","23.6398","25.1256",{"$nulls":3},"cellular glucuronidation;glucuronoside catabolic process","hydrolase activity, hydrolyzing O-glycosyl compounds;mycophenolic acid acyl-glucuronide esterase activity","cytosol;mitochondrial matrix;mitochondrion",{"$nulls":3},15,15,15,"59.5","59.5","59.5","33.932",0,"305.89",6181100000,177,"0.171805",1,"0.357063","0.45414","sp|Q9NUJ1|ABHDA_HUMAN","sp|Q9NUJ1|ABHDA_HUMAN",4730,"Q9NUJ1","ABHDA_HUMAN","Mycophenolic acid acyl-glucuronide esterase, mitochondrial",null,"ABHD10"]
["19.9479","17.8039","18.9233","19.5137","17.207","18.8866",{"$nulls":9},3,3,3,"13.8","13.8","13.8","30.623",0,"20.147",57349000,6,"0.14251",1,"0.355942","0.384375","tr|J3KRR1|J3KRR1_HUMAN;tr|J9JIC5|J9JIC5_HUMAN;sp|Q9HAS0|NJMU_HUMAN;tr|K7ERX0|K7ERX0_HUMAN;tr|J3QKQ1|J3QKQ1_HUMAN;tr|K7EIQ2|K7EIQ2_HUMAN;tr|K7EII1|K7EII1_HUMAN","tr|J3KRR1|J3KRR1_HUMAN;tr|J9JIC5|J9JIC5_HUMAN;sp|Q9HAS0|NJMU_HUMAN",4559,"J3KRR1","J3KRR1_HUMAN",null,null,"C17orf75"]
["23.079","21.553","21.4359","22.6042","20.9795","21.4224",{"$nulls":3},"ATP biosynthetic process;ATP synthesis coupled proton transport;cristae formation;mitochondrial ATP synthesis coupled proton transport;oxidative phosphorylation;response to copper ion","ATPase activity;proton-transporting ATP synthase activity, rotational mechanism;transmembrane transporter activity;transporter activity","mitochondrial inner membrane;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,2,2,2,"13.7","13.7","13.7","17.49",0,"13.199",180360000,12,"0.188543",1,"0.353911","0.493041","sp|P30049|ATPD_HUMAN","sp|P30049|ATPD_HUMAN",1371,"P30049","ATPD_HUMAN","ATP synthase subunit delta, mitochondrial",null,"ATP5D"]
["26.1115","25.4525","25.0912","25.0104","25.0274","25.5566",{"$nulls":3},"activation-induced cell death of T cells;erythrocyte development;G1/S transition of mitotic cell cycle;gastrulation;glucose homeostasis;mitotic cell cycle checkpoint;negative regulation of apoptotic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;oogenesis stage;placenta development;positive regulation of apoptotic process;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;T cell differentiation in thymus;T cell proliferation involved in immune response;TOR signaling;translation;translational initiation;viral transcription","protein kinase binding;RNA binding;structural constituent of ribosome","cell body;cytoplasmic ribonucleoprotein granule;cytosol;cytosolic small ribosomal subunit;dendrite;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;polysome;small ribosomal subunit","Apelin signaling pathway;EGFR tyrosine kinase inhibitor resistance;HIF-1 signaling pathway;Insulin signaling pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;Proteoglycans in cancer;Ribosome;Thermogenesis",null,null,12,12,12,"36.9","36.9","36.9","28.68",0,"200.29",17214000000,424,"0.434743",1,"0.353612","1.01502","sp|P62753|RS6_HUMAN;tr|A2A3R5|A2A3R5_HUMAN;tr|A2A3R7|A2A3R7_HUMAN","sp|P62753|RS6_HUMAN;tr|A2A3R5|A2A3R5_HUMAN",1989,"P62753","RS6_HUMAN","40S ribosomal protein S6",null,"RPS6"]
["21.0405","18.541",1,"19.6519","18.8724",1,{"$nulls":3},"epithelial cell differentiation;mRNA splicing, via spliceosome;RNA processing;RNA splicing","RNA binding","nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},7,6,6,"26.3",24,24,"36.926",0,"26.395",218990000,11,"0.0132889",1,"0.352381","0.0401941","sp|P31942|HNRH3_HUMAN","sp|P31942|HNRH3_HUMAN",1413,"P31942","HNRH3_HUMAN","Heterogeneous nuclear ribonucleoprotein H3","nRNP H3","HNRNPH3"]
["18.0677","16.5785","17.4265","17.852","16.0362","17.1327",{"$nulls":3},"endosome organization;neutrophil degranulation;osteoblast differentiation;protein transport;receptor-mediated endocytosis;regulation of early endosome to late endosome transport;regulation of early endosome to recycling endosome transport",null,"azurophil granule membrane;cytosol;early endosome membrane;endosome membrane;extracellular exosome;intracellular membrane-bounded organelle;lysosomal membrane;membrane;plasma membrane;secretory granule membrane",{"$nulls":3},16,16,16,10,10,10,"254.41",0,"85.903",200390000,34,"0.197812",1,"0.350605","0.514313","sp|O75165|DJC13_HUMAN;tr|H0YA63|H0YA63_HUMAN;tr|H0Y8Q2|H0Y8Q2_HUMAN","sp|O75165|DJC13_HUMAN",553,"O75165","DJC13_HUMAN","DnaJ homolog subfamily C member 13",null,"DNAJC13"]
["20.4015","20.7632","20.3178","20.1799","19.7302","20.5222",{"$nulls":3},"regulation of phosphorylation of RNA polymerase II C-terminal domain","peptidyl-prolyl cis-trans isomerase activity;RNA binding","cytosol;nucleoplasm",{"$nulls":3},10,10,10,"25.8","25.8","25.8","57.224",0,"53.598",512100000,48,"0.585102",1,"0.350068","1.31133","sp|Q8WUA2|PPIL4_HUMAN","sp|Q8WUA2|PPIL4_HUMAN",3594,"Q8WUA2","PPIL4_HUMAN","Peptidyl-prolyl cis-trans isomerase-like 4","PIase","PPIL4"]
["19.2733","20.6167","21.2231","18.2516","20.7158","21.0974",{"$nulls":6},"Hippo signaling pathway;Human papillomavirus infection;Tight junction;Viral carcinogenesis",null,null,14,14,13,"11.4","11.4","10.8","174.91",0,"39.441",900160000,29,"0.120015",1,"0.349476","0.329156","tr|A0A0G2JNZ2|A0A0G2JNZ2_HUMAN;sp|Q14160|SCRIB_HUMAN;tr|A0A0G2JMS7|A0A0G2JMS7_HUMAN;tr|A0A0G2JPP5|A0A0G2JPP5_HUMAN;tr|H0YCG0|H0YCG0_HUMAN;tr|H0YDF9|H0YDF9_HUMAN","tr|A0A0G2JNZ2|A0A0G2JNZ2_HUMAN;sp|Q14160|SCRIB_HUMAN;tr|A0A0G2JMS7|A0A0G2JMS7_HUMAN;tr|A0A0G2JPP5|A0A0G2JPP5_HUMAN",2444,"A0A0G2JNZ2","A0A0G2JNZ2_HUMAN",null,null,"SCRIB"]
["19.5229","18.8284","19.9499","19.7165","18.1801","19.3598",{"$nulls":3},"rRNA processing","RNA binding","nucleolus;nucleus;preribosome, large subunit precursor;preribosome, small subunit precursor",{"$nulls":3},14,14,14,"32.8","32.8","32.8","52.839",0,"156.42",744470000,82,"0.242059",1,"0.348302","0.613498","sp|P56182|RRP1_HUMAN;tr|D6RE82|D6RE82_HUMAN","sp|P56182|RRP1_HUMAN",1860,"P56182","RRP1_HUMAN","Ribosomal RNA processing protein 1 homolog A",null,"RRP1"]
["17.686",1,"16.345","16.3649",1,"16.6239",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;metal ion binding","nucleus",{"$nulls":3},10,10,10,"24.3","24.3","24.3","63.629",0,"52.786",392070000,39,"0.0154786",1,"0.347415","0.0467054","sp|P17029|ZKSC1_HUMAN;tr|E9PC66|E9PC66_HUMAN;tr|B3KRF7|B3KRF7_HUMAN;tr|C9JRM9|C9JRM9_HUMAN","sp|P17029|ZKSC1_HUMAN;tr|E9PC66|E9PC66_HUMAN;tr|B3KRF7|B3KRF7_HUMAN",1145,"P17029","ZKSC1_HUMAN","Zinc finger protein with KRAB and SCAN domains 1",null,"ZKSCAN1"]
["26.8299","27.1234","27.0832","26.5239","26.6396","26.8353",{"$nulls":3},"apoptotic DNA fragmentation;cell chemotaxis;cellular response to lipopolysaccharide;chromatin organization;defense response to Gram-negative bacterium;defense response to Gram-positive bacterium;DNA geometric change;DNA ligation involved in DNA repair;DNA topological change;inflammatory response to antigenic stimulus;innate immune response;male gonad development;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of transcription, DNA-templated;nucleosome assembly;positive regulation of DNA binding;positive regulation of endothelial cell proliferation;positive regulation of erythrocyte differentiation;positive regulation of innate immune response;positive regulation of interferon-beta production;positive regulation of megakaryocyte differentiation;positive regulation of nuclease activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of neurogenesis;regulation of stem cell proliferation;regulation of transcription from RNA polymerase II promoter;response to drug;response to lipopolysaccharide;response to steroid hormone;spermatid nucleus differentiation;transcription, DNA-templated;V(D)J recombination","chemoattractant activity;damaged DNA binding;DNA binding;DNA binding transcription factor activity;DNA binding, bending;double-stranded DNA binding;drug binding;enhancer sequence-specific DNA binding;four-way junction DNA binding;non-sequence-specific DNA binding, bending;protein domain specific binding;RAGE receptor binding;RNA binding;single-stranded DNA binding;supercoiled DNA binding;transcription factor binding;transcription regulatory region DNA binding","cell;condensed chromosome;cytoplasm;extracellular space;nuclear chromatin;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex",{"$nulls":3},8,7,7,"28.2","22.5","22.5","24.033",0,"139.79",6136400000,141,"1.25628",1,"0.345885","2.67656","sp|P26583|HMGB2_HUMAN;tr|D6R9A6|D6R9A6_HUMAN","sp|P26583|HMGB2_HUMAN;tr|D6R9A6|D6R9A6_HUMAN",1309,"P26583","HMGB2_HUMAN","High mobility group protein B2",null,"HMGB2"]
["21.901","20.6406","21.3029","21.5128","20.083","21.2157",{"$nulls":3},"animal organ morphogenesis;cytochrome c-heme linkage;oxidation-reduction process","holocytochrome-c synthase activity;metal ion binding","mitochondrial inner membrane;mitochondrion","Porphyrin and chlorophyll metabolism",null,null,7,7,7,"39.9","39.9","39.9","30.601",0,"74.316",362970000,37,"0.238915",1,"0.344331","0.606567","sp|P53701|CCHL_HUMAN","sp|P53701|CCHL_HUMAN",1806,"P53701","CCHL_HUMAN","Cytochrome c-type heme lyase","CHL","HCCS"]
["26.9055","26.2556","26.3533","26.3628","25.6467","26.4753",{"$nulls":3},"cell proliferation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;rRNA processing;sister chromatid cohesion;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","DNA binding;RNA binding;structural constituent of ribosome;zinc ion binding","cytosol;cytosolic small ribosomal subunit;nucleoplasm;nucleus;ribosome","Ribosome",null,null,5,5,2,"40.5","40.5","14.3","9.461",0,"59.324",16877000000,381,"0.448785",1,"0.343211","1.04307","sp|P42677|RS27_HUMAN;tr|Q5T4L4|Q5T4L4_HUMAN;tr|C9J1C5|C9J1C5_HUMAN","sp|P42677|RS27_HUMAN;tr|Q5T4L4|Q5T4L4_HUMAN",1553,"P42677","RS27_HUMAN","40S ribosomal protein S27",null,"RPS27"]
["24.8871","24.8078","23.8546","24.1095","24.4206","23.9955",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","structural constituent of ribosome;zinc ion binding","cytosol;cytosolic small ribosomal subunit;extracellular exosome;focal adhesion;nucleoplasm;small ribosomal subunit","Ribosome",null,null,2,2,2,"32.1","32.1","32.1","6.6767",0,"53.681",1661200000,34,"0.40776",1,"0.341298","0.960812","sp|P62273|RS29_HUMAN;tr|A0A087WTT6|A0A087WTT6_HUMAN","sp|P62273|RS29_HUMAN;tr|A0A087WTT6|A0A087WTT6_HUMAN",1968,"P62273","RS29_HUMAN","40S ribosomal protein S29",null,"RPS29"]
["19.3276","19.4817","16.2349","18.3551","18.7094","16.9559",{"$nulls":3},"peroxisome fission;peroxisome organization;protein homooligomerization;regulation of peroxisome size;signal transduction","protein homodimerization activity","extracellular exosome;integral component of peroxisomal membrane;membrane;peroxisomal membrane;peroxisome;protein complex","Peroxisome",null,null,5,5,5,"27.8","27.8","27.8","28.431",0,"9.013",66112000,9,"0.103635",1,"0.34127","0.287923","sp|O96011|PX11B_HUMAN;tr|H7C3V6|H7C3V6_HUMAN","sp|O96011|PX11B_HUMAN",814,"O96011","PX11B_HUMAN","Peroxisomal membrane protein 11B",null,"PEX11B"]
["19.9461","18.7077","20.8411","20.631","18.0442","19.7985",{"$nulls":4},"RNA binding","nucleolus",{"$nulls":3},3,3,3,"34.8","34.8","34.8","15.017",0,"22.993",334360000,40,"0.127085",1,"0.340348","0.346679","tr|D6RC52|D6RC52_HUMAN;tr|D6RCB9|D6RCB9_HUMAN;sp|Q9NX24|NHP2_HUMAN;tr|J3QSY4|J3QSY4_HUMAN;tr|H0YC83|H0YC83_HUMAN","tr|D6RC52|D6RC52_HUMAN;tr|D6RCB9|D6RCB9_HUMAN;sp|Q9NX24|NHP2_HUMAN;tr|J3QSY4|J3QSY4_HUMAN",4809,"D6RC52","D6RC52_HUMAN",null,null,"NHP2"]
["21.4045","19.7687","20.9005","21.1323","19.4526","20.472",{"$nulls":3},"peptidyl-proline hydroxylation to 3-hydroxy-L-proline",null,"endoplasmic reticulum",{"$nulls":3},6,6,6,17,17,17,"41.432",0,"14.328",443110000,23,"0.188522",1,"0.338931","0.492994","tr|C9JP16|C9JP16_HUMAN;sp|O75718|CRTAP_HUMAN","tr|C9JP16|C9JP16_HUMAN;sp|O75718|CRTAP_HUMAN",628,"C9JP16","C9JP16_HUMAN",null,null,"CRTAP"]
["20.7723","20.3193",1,"19.4395","20.6366",1,{"$nulls":3},"cytoplasmic translation;ribosomal large subunit biogenesis","RNA binding;structural constituent of ribosome","cytosolic large ribosomal subunit;extracellular exosome","Ribosome",null,null,8,2,2,"44.1","11.7","11.7","17.256",0,"6.4715",291640000,6,"0.0122808",1,"0.338489","0.037186","sp|Q9UNX3|RL26L_HUMAN;tr|E5RIT6|E5RIT6_HUMAN;tr|E5RHH1|E5RHH1_HUMAN","sp|Q9UNX3|RL26L_HUMAN;tr|E5RIT6|E5RIT6_HUMAN",5164,"Q9UNX3","RL26L_HUMAN","60S ribosomal protein L26-like 1",null,"RPL26L1"]
["24.3254","23.3415","24.0399","23.9348","22.9144","23.8423",{"$nulls":3},"cellular response to growth factor stimulus;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;muscle contraction;muscle organ development;negative regulation of catenin import into nucleus;negative regulation of fibroblast proliferation;positive regulation of protein export from nucleus;regulation of canonical Wnt signaling pathway;skeletal muscle cell differentiation","actin binding;beta-tubulin binding;cadherin binding","cytoplasm;endoplasmic reticulum;integral component of membrane;membrane;microtubule;nuclear envelope;nuclear inner membrane;nuclear membrane;nuclear outer membrane;nucleoplasm","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM)",null,null,15,15,15,"64.6","64.6","64.6","28.994",0,"185.03",2046200000,119,"0.316478",1,"0.338436","0.773255","sp|P50402|EMD_HUMAN;tr|Q5HY57|Q5HY57_HUMAN;tr|F8WEQ1|F8WEQ1_HUMAN","sp|P50402|EMD_HUMAN;tr|Q5HY57|Q5HY57_HUMAN",1705,"P50402","EMD_HUMAN","Emerin",null,"EMD"]
["22.2341","21.439","21.3317","21.7043","21.192","21.0991",{"$nulls":3},"abortive mitotic cell cycle;activation of MAPK activity;atrioventricular canal development;axon guidance;Bergmann glial cell differentiation;brain development;cellular response to epidermal growth factor stimulus;cellular response to mechanical stimulus;cerebellar cortex formation;DNA damage checkpoint;ephrin receptor signaling pathway;epidermal growth factor receptor signaling pathway;ERBB signaling pathway;face morphogenesis;fibroblast growth factor receptor signaling pathway;genitalia development;glucose homeostasis;heart development;homeostasis of number of cells within a tissue;hormone metabolic process;hormone-mediated signaling pathway;inner ear development;integrin-mediated signaling pathway;intestinal epithelial cell migration;leukocyte migration;megakaryocyte development;microvillus organization;multicellular organism growth;multicellular organismal reproductive process;negative regulation of cell adhesion mediated by integrin;negative regulation of cortisol secretion;negative regulation of growth hormone secretion;negative regulation of insulin secretion;neurotrophin TRK receptor signaling pathway;organ growth;peptidyl-tyrosine dephosphorylation;platelet activation;platelet formation;platelet-derived growth factor receptor signaling pathway;positive regulation of ERK1 and ERK2 cascade;positive regulation of glucose import in response to insulin stimulus;positive regulation of hormone secretion;positive regulation of mitotic cell cycle;positive regulation of protein kinase B signaling;regulation of cell adhesion mediated by integrin;regulation of multicellular organism growth;regulation of protein complex assembly;regulation of protein export from nucleus;regulation of type I interferon-mediated signaling pathway;T cell costimulation;triglyceride metabolic process","1-phosphatidylinositol-3-kinase activity;cell adhesion molecule binding;D1 dopamine receptor binding;insulin receptor binding;insulin receptor substrate binding;non-membrane spanning protein tyrosine phosphatase activity;peptide hormone receptor binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;phospholipase binding;phosphoprotein phosphatase activity;protein domain specific binding;protein tyrosine phosphatase activity;receptor tyrosine kinase binding;SH3/SH2 adaptor activity","cytoplasm;cytosol;mitochondrion;nucleoplasm;nucleus;protein complex","Adipocytokine signaling pathway;Axon guidance;Chronic myeloid leukemia;C-type lectin receptor signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Herpes simplex virus 1 infection;Insulin resistance;Jak-STAT signaling pathway;Leukocyte transendothelial migration;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;Proteoglycans in cancer;Ras signaling pathway;Renal cell carcinoma",null,null,21,21,21,"42.9","42.9","42.9","68.436",0,"134.02",1214700000,95,"0.420405",1,"0.336512","0.986274","sp|Q06124|PTN11_HUMAN;tr|H0YF12|H0YF12_HUMAN","sp|Q06124|PTN11_HUMAN",2200,"Q06124","PTN11_HUMAN","Tyrosine-protein phosphatase non-receptor type 11",null,"PTPN11"]
["20.2928","20.1316","18.923","20.2141","19.3821","18.7429",{"$nulls":3},"positive regulation of proteasomal ubiquitin-dependent protein catabolic process;post-translational protein modification;protein ubiquitination;response to interferon-gamma;response to tumor necrosis factor;ubiquitin-dependent protein catabolic process",null,"cytosol;nucleus",{"$nulls":3},9,9,9,"18.5","18.5","18.5","70.537",0,"44.777",247280000,27,"0.215274",1,"0.336105","0.553899","sp|Q9Y5A7|NUB1_HUMAN;tr|H3BM14|H3BM14_HUMAN;tr|H3BM74|H3BM74_HUMAN;tr|F8WDB6|F8WDB6_HUMAN;tr|C9JRT6|C9JRT6_HUMAN;tr|C9J7X7|C9J7X7_HUMAN;tr|H7C5N1|H7C5N1_HUMAN;tr|H7C5E1|H7C5E1_HUMAN","sp|Q9Y5A7|NUB1_HUMAN;tr|H3BM14|H3BM14_HUMAN;tr|H3BM74|H3BM74_HUMAN;tr|F8WDB6|F8WDB6_HUMAN;tr|C9JRT6|C9JRT6_HUMAN",5347,"Q9Y5A7","NUB1_HUMAN","NEDD8 ultimate buster 1",null,"NUB1"]
["21.8041","19.0228","21.5977","20.7717","19.0211","21.6421",{"$nulls":3},"ciliary basal body-plasma membrane docking;cytoplasmic microtubule organization;G2/M transition of mitotic cell cycle;meiotic spindle organization;microtubule cytoskeleton organization;microtubule nucleation;regulation of G2/M transition of mitotic cell cycle","GTP binding;GTPase activity;identical protein binding;structural constituent of cytoskeleton","apical part of cell;cell leading edge;centriole;centrosome;ciliary basal body;condensed nuclear chromosome;cytoplasm;cytoplasmic microtubule;cytosol;gamma-tubulin complex;non-motile cilium;pericentriolar material;polar microtubule;recycling endosome","Human papillomavirus infection",null,null,10,10,10,"43.9","43.9","43.9","51.169",0,"103.73",444460000,42,"0.100284",1,"0.329908","0.279374","sp|P23258|TBG1_HUMAN;sp|Q9NRH3|TBG2_HUMAN;tr|K7EIS0|K7EIS0_HUMAN;tr|K7EKE5|K7EKE5_HUMAN","sp|P23258|TBG1_HUMAN;sp|Q9NRH3|TBG2_HUMAN;tr|K7EIS0|K7EIS0_HUMAN",1258,"P23258","TBG1_HUMAN","Tubulin gamma-1 chain",null,"TUBG1"]
["22.7959","21.155","22.1722","22.7188","20.528","21.889",{"$nulls":3},"extracellular negative regulation of signal transduction;negative regulation of amyloid-beta clearance;negative regulation of cell death;negative regulation of protein binding;negative regulation of receptor internalization;negative regulation of very-low-density lipoprotein particle clearance;positive regulation of amyloid-beta clearance;regulation of receptor-mediated endocytosis;transcytosis","amyloid-beta binding;heparin binding;lipase binding;low-density lipoprotein particle receptor binding;receptor antagonist activity;receptor binding;very-low-density lipoprotein particle receptor binding","cell surface;cis-Golgi network;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;endosome;endosome lumen;extracellular region;Golgi apparatus;Golgi lumen;plasma membrane;rough endoplasmic reticulum lumen","Cholesterol metabolism",null,null,14,14,14,"38.9","38.9","38.9","41.465",0,"103.31",770690000,35,"0.154201",1,"0.329085","0.412489","sp|P30533|AMRP_HUMAN;tr|D6REW6|D6REW6_HUMAN","sp|P30533|AMRP_HUMAN",1388,"P30533","AMRP_HUMAN","Alpha-2-macroglobulin receptor-associated protein","lpha-2-MRAP","LRPAP1"]
["23.1264","21.6804","21.898","21.7122","21.8596","22.147",{"$nulls":3},"multicellular organism development;negative regulation of catalytic activity;negative regulation of nitric-oxide synthase activity;protein ubiquitination;regulation of nitric-oxide synthase activity","RNA binding;ubiquitin protein ligase activity","cytoplasm;cytosol;Golgi membrane;nucleus",{"$nulls":3},10,10,10,"50.2","50.2","50.2","33.172",0,"148.55",982010000,71,"0.283076",1,"0.328672","0.702488","sp|Q9Y314|NOSIP_HUMAN;tr|A0A075B6F9|A0A075B6F9_HUMAN;tr|M0R3B2|M0R3B2_HUMAN;tr|A0A075B797|A0A075B797_HUMAN;tr|M0R1K2|M0R1K2_HUMAN;tr|M0QX85|M0QX85_HUMAN;tr|M0R1T7|M0R1T7_HUMAN","sp|Q9Y314|NOSIP_HUMAN;tr|A0A075B6F9|A0A075B6F9_HUMAN;tr|M0R3B2|M0R3B2_HUMAN",5263,"Q9Y314","NOSIP_HUMAN","Nitric oxide synthase-interacting protein",null,"NOSIP"]
["25.208","24.6978","25.1021","24.6882","24.4601","24.8757",{"$nulls":3},"Leydig cell differentiation;male sex determination;mRNA 3'-splice site recognition;mRNA splicing, via spliceosome;negative regulation of smooth muscle cell proliferation;nuclear body organization;regulation of steroid biosynthetic process;regulation of transcription, DNA-templated;spliceosomal complex assembly;transcription, DNA-templated","identical protein binding;pre-mRNA branch point binding;RNA binding;transcription corepressor activity;zinc ion binding","nuclear body;nucleoplasm;nucleus;ribosome;spliceosomal complex",{"$nulls":3},14,14,12,"32.4","32.4",25,"68.329",0,"304.82",4385300000,131,"0.768609",1,"0.327988","1.66936","sp|Q15637|SF01_HUMAN;tr|C9J792|C9J792_HUMAN;tr|F8WEV5|F8WEV5_HUMAN","sp|Q15637|SF01_HUMAN",2623,"Q15637","SF01_HUMAN","Splicing factor 1",null,"SF1"]
["25.2979","23.992","24.8662","24.8694","23.6311","24.6744",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of NF-kappaB transcription factor activity;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;proteolysis involved in cellular protein catabolic process;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of inflammatory response;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activity;NF-kappaB binding;purine ribonucleoside triphosphate binding;RNA binding;threonine-type endopeptidase activity","cytosol;extracellular exosome;myofibril;nuclear matrix;nucleoplasm;nucleus;P-body;polysome;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex;sarcomere","Proteasome",null,null,10,10,10,"48.8","48.8","48.8","27.399",0,"79.483",4146200000,129,"0.236774",1,"0.327049","0.601839","sp|P60900|PSA6_HUMAN;tr|G3V5Z7|G3V5Z7_HUMAN;tr|G3V295|G3V295_HUMAN;tr|G3V3I1|G3V3I1_HUMAN;tr|G3V3U4|G3V3U4_HUMAN;tr|H0YJC4|H0YJC4_HUMAN;tr|G3V4S5|G3V4S5_HUMAN;tr|G3V2S7|G3V2S7_HUMAN","sp|P60900|PSA6_HUMAN;tr|G3V5Z7|G3V5Z7_HUMAN;tr|G3V295|G3V295_HUMAN;tr|G3V3I1|G3V3I1_HUMAN;tr|G3V3U4|G3V3U4_HUMAN",1902,"P60900","PSA6_HUMAN","Proteasome subunit alpha type-6",null,"PSMA6"]
["22.6173","20.5652","21.6937","22.1233","19.8488","21.9241",{"$nulls":3},"heme biosynthetic process;protoporphyrinogen IX biosynthetic process","uroporphyrinogen decarboxylase activity","cytosol;nucleoplasm","Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,13,13,13,"59.7","59.7","59.7","40.786",0,"118.89",419810000,35,"0.127643",1,"0.326684","0.348055","sp|P06132|DCUP_HUMAN;tr|H0Y5R6|H0Y5R6_HUMAN;tr|Q5T446|Q5T446_HUMAN","sp|P06132|DCUP_HUMAN;tr|H0Y5R6|H0Y5R6_HUMAN",908,"P06132","DCUP_HUMAN","Uroporphyrinogen decarboxylase","PD;RO-D","UROD"]
["25.1662","23.7649","24.9358","25.0896","23.1328","24.6692",{"$nulls":3},"blood circulation;cholesterol biosynthetic process;L-ascorbic acid metabolic process;neutrophil degranulation;xenobiotic metabolic process","ADP binding;AMP binding;cytochrome-b5 reductase activity, acting on NAD(P)H;FAD binding;flavin adenine dinucleotide binding;NAD binding;oxidoreductase activity","azurophil granule lumen;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;extracellular region;hemoglobin complex;lipid droplet;membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion","Amino sugar and nucleotide sugar metabolism",null,null,14,14,14,"61.5","61.5","61.5","34.234",0,"242.71",3361600000,141,"0.166471",1,"0.325088","0.441604","sp|P00387|NB5R3_HUMAN;tr|B1AHF3|B1AHF3_HUMAN","sp|P00387|NB5R3_HUMAN;tr|B1AHF3|B1AHF3_HUMAN",822,"P00387","NB5R3_HUMAN","NADH-cytochrome b5 reductase 3","5R;ytochrome b5 reductase","CYB5R3"]
["21.0922","19.4775","20.9793","21.5114","19.1307","19.9349",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination",null,"mitochondrial inner membrane;mitochondrial small ribosomal subunit","Ribosome",null,null,7,7,7,"38.8","38.8","38.8","22.999",0,"28.219",192860000,16,"0.137304",1,"0.32401","0.371732","sp|P82664|RT10_HUMAN","sp|P82664|RT10_HUMAN",2076,"P82664","RT10_HUMAN","28S ribosomal protein S10, mitochondrial","10mt;RP-S10","MRPS10"]
["18.6878","17.5951",1,"18.1639","17.1488",1,{"$nulls":3},"7-methylguanosine mRNA capping;adult heart development;cell proliferation;DNA repair;G1/S transition of mitotic cell cycle;G2/M transition of mitotic cell cycle;negative regulation of apoptotic process;nucleotide-excision repair, preincision complex assembly;positive regulation of smooth muscle cell proliferation;positive regulation of transcription from RNA polymerase II promoter;protein complex assembly;protein phosphorylation;regulation of cyclin-dependent protein serine/threonine kinase activity;regulation of transcription from RNA polymerase II promoter;response to calcium ion;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair;ventricular system development","cyclin-dependent protein serine/threonine kinase activator activity;protein N-terminus binding;zinc ion binding","cytosol;holo TFIIH complex;nucleoplasm","Basal transcription factors;Nucleotide excision repair",null,null,3,3,3,"13.6","13.6","13.6","35.823",0,"20.716",64882000,5,"0.0134017",1,"0.323377","0.0405302","sp|P51948|MAT1_HUMAN;tr|H0YJ92|H0YJ92_HUMAN;tr|H0YJF2|H0YJF2_HUMAN","sp|P51948|MAT1_HUMAN;tr|H0YJ92|H0YJ92_HUMAN;tr|H0YJF2|H0YJF2_HUMAN",1760,"P51948","MAT1_HUMAN","CDK-activating kinase assembly factor MAT1",null,"MNAT1"]
["25.0721","23.2198","24.2694","24.849","22.741","24.004",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational elongation;translational initiation;viral transcription","structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;membrane","Ribosome",null,null,5,5,5,"69.6","69.6","69.6","11.665",0,"37.596",989810000,49,"0.14734",1,"0.322425","0.396036","sp|P05387|RLA2_HUMAN;tr|H0YDD8|H0YDD8_HUMAN","sp|P05387|RLA2_HUMAN",902,"P05387","RLA2_HUMAN","60S acidic ribosomal protein P2",null,"RPLP2"]
["21.5826","21.7012","22.057","21.5596","21.2801","21.5385",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome","Ribosome",null,null,3,3,3,25,25,25,"10.165",0,"13.414",273240000,19,"0.887245",1,"0.320818","1.90396","sp|Q9BQ48|RM34_HUMAN;tr|M0R226|M0R226_HUMAN","sp|Q9BQ48|RM34_HUMAN;tr|M0R226|M0R226_HUMAN",4135,"Q9BQ48","RM34_HUMAN","39S ribosomal protein L34, mitochondrial","34mt;RP-L34","MRPL34"]
["24.114","22.8684","23.8818","24.2075","22.0333","23.6636",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;apoptotic process;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of G1/S transition of mitotic cell cycle;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of proteasomal protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activator activity;identical protein binding;MDM2/MDM4 family protein binding;p53 binding","cytoplasm;cytosol;membrane;nucleoplasm;nucleus;proteasome activator complex;proteasome complex","Antigen processing and presentation;Hepatitis C;Proteasome",null,null,15,15,15,"70.5","70.5","70.5","29.506",0,"161.14",1603600000,75,"0.158486",1,"0.31996","0.422701","sp|P61289|PSME3_HUMAN;tr|K9J957|K9J957_HUMAN;tr|B3KQ25|B3KQ25_HUMAN;tr|K7ESG5|K7ESG5_HUMAN;tr|K7ENH2|K7ENH2_HUMAN;tr|A0A087WTV2|A0A087WTV2_HUMAN;tr|K7EPX6|K7EPX6_HUMAN;tr|K7EKR3|K7EKR3_HUMAN;tr|K7EMD0|K7EMD0_HUMAN;tr|B7Z8D3|B7Z8D3_HUMAN","sp|P61289|PSME3_HUMAN;tr|K9J957|K9J957_HUMAN;tr|B3KQ25|B3KQ25_HUMAN;tr|K7ESG5|K7ESG5_HUMAN;tr|K7ENH2|K7ENH2_HUMAN;tr|A0A087WTV2|A0A087WTV2_HUMAN",1928,"P61289","PSME3_HUMAN","Proteasome activator complex subunit 3",null,"PSME3"]
["28.4506","27.313","27.4906","27.7906","27.0898","27.4216",{"$nulls":3},"actin cytoskeleton reorganization;adaptive immune response;alpha-beta T cell differentiation;arachidonic acid secretion;cell surface receptor signaling pathway;cellular response to glucocorticoid stimulus;cellular response to hydrogen peroxide;cellular response to vascular endothelial growth factor stimulus;DNA duplex unwinding;DNA rewinding;endocrine pancreas development;estrous cycle;gliogenesis;G-protein coupled receptor signaling pathway;G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;granulocyte chemotaxis;hepatocyte differentiation;inflammatory response;innate immune response;insulin secretion;keratinocyte differentiation;monocyte chemotaxis;myoblast migration involved in skeletal muscle regeneration;negative regulation of apoptotic process;negative regulation of exocytosis;negative regulation of interleukin-8 secretion;negative regulation of phospholipase A2 activity;negative regulation of T-helper 2 cell differentiation;neutrophil clearance;neutrophil homeostasis;peptide cross-linking;phagocytosis;positive regulation of cell migration involved in sprouting angiogenesis;positive regulation of G1/S transition of mitotic cell cycle;positive regulation of interleukin-2 production;positive regulation of neutrophil apoptotic process;positive regulation of prostaglandin biosynthetic process;positive regulation of T cell proliferation;positive regulation of T-helper 1 cell differentiation;positive regulation of vesicle fusion;positive regulation of wound healing;prolactin secretion;prostate gland development;regulation of cell shape;regulation of hormone secretion;regulation of inflammatory response;regulation of interleukin-1 production;regulation of leukocyte migration;response to drug;response to estradiol;response to interleukin-1;response to peptide hormone;response to X-ray;signal transduction","annealing helicase activity;cadherin binding involved in cell-cell adhesion;calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;double-stranded DNA-dependent ATPase activity;helicase activity;phospholipase A2 inhibitor activity;phospholipid binding;protein binding, bridging;protein homodimerization activity;receptor binding;single-stranded DNA binding;single-stranded RNA binding;structural molecule activity","apical plasma membrane;basolateral plasma membrane;cell surface;cell-cell adherens junction;cornified envelope;cytoplasm;cytoplasmic vesicle membrane;cytosol;early endosome membrane;endosome;extracellular exosome;extracellular region;extracellular space;extrinsic component of endosome membrane;extrinsic component of external side of plasma membrane;extrinsic component of membrane;focal adhesion;lateral plasma membrane;mast cell granule;mitochondrial membrane;motile cilium;nucleoplasm;nucleus;phagocytic cup;plasma membrane;protein complex;sarcolemma;vesicle",{"$nulls":3},25,25,25,"67.3","67.3","67.3","38.714",0,"323.31",36486000000,395,"0.319449",1,"0.317397","0.779486","sp|P04083|ANXA1_HUMAN;tr|Q5T3N1|Q5T3N1_HUMAN;tr|Q5T3N0|Q5T3N0_HUMAN","sp|P04083|ANXA1_HUMAN;tr|Q5T3N1|Q5T3N1_HUMAN",866,"P04083","ANXA1_HUMAN","Annexin A1",null,"ANXA1"]
["22.9048","22.1974","22.3543","22.6013","21.6113","22.2938",{"$nulls":4},"ATP binding;RNA binding","fibrillar center;nuclear speck",{"$nulls":3},36,36,1,"37.7","37.7","1.9","117.46",0,"323.31",2859300000,169,"0.364603",1,"0.316701","0.873049","tr|A0A0C4DG89|A0A0C4DG89_HUMAN","tr|A0A0C4DG89|A0A0C4DG89_HUMAN",5461,"A0A0C4DG89","A0A0C4DG89_HUMAN",null,null,"DDX46"]
["16.495","17.6083","17.7013","16.1085","17.1648","17.5859",{"$nulls":3},"DNA double-strand break processing;double-strand break repair;double-strand break repair via homologous recombination;nucleic acid phosphodiester bond hydrolysis","3'-5' exonuclease activity;exodeoxyribonuclease I activity;nucleic acid binding;single-stranded DNA 3'-5' exodeoxyribonuclease activity","cytoplasm;nucleus",{"$nulls":3},11,11,11,"23.7","23.7","23.7","70.352",0,"35.993",217650000,36,"0.208179",1,"0.315148","0.537889","sp|Q9NVH0|EXD2_HUMAN;tr|C9JLF4|C9JLF4_HUMAN","sp|Q9NVH0|EXD2_HUMAN",4760,"Q9NVH0","EXD2_HUMAN","Exonuclease 3'-5' domain-containing protein 2 {ECO:0000312|HGNC:HGNC:20217}",null,"EXD2"]
["25.2873","22.9103","23.6392","24.4605","22.4658","23.9708",{"$nulls":3},"cellular response to amino acid stimulus;negative regulation of cyclin-dependent protein serine/threonine kinase activity;NLS-bearing protein import into nucleus;positive regulation of protein import into nucleus;protein import into nucleus, translocation;ribosomal protein import into nucleus;viral process","GTPase inhibitor activity;nuclear localization sequence binding;protein transporter activity;Ran GTPase binding;RNA binding","cytoplasm;membrane;nuclear membrane;nuclear periphery;nuclear pore;nucleolus;nucleus",{"$nulls":3},44,44,35,62,62,"52.4","123.63",0,"323.31",8851200000,382,"0.123919",1,"0.313229","0.33885","sp|O00410|IPO5_HUMAN;tr|H0Y8C6|H0Y8C6_HUMAN;tr|E7ETV3|E7ETV3_HUMAN;tr|E7EQT5|E7EQT5_HUMAN;tr|C9JMV5|C9JMV5_HUMAN;tr|E7EV12|E7EV12_HUMAN;tr|C9JZD8|C9JZD8_HUMAN;tr|E7EWK4|E7EWK4_HUMAN;tr|E7EX05|E7EX05_HUMAN;tr|C9JZ53|C9JZ53_HUMAN;tr|C9JQT6|C9JQT6_HUMAN;tr|E7ESA1|E7ESA1_HUMAN;tr|E7ESZ1|E7ESZ1_HUMAN;tr|E7ETV8|E7ETV8_HUMAN;tr|C9J875|C9J875_HUMAN;tr|C9JXE0|C9JXE0_HUMAN","sp|O00410|IPO5_HUMAN;tr|H0Y8C6|H0Y8C6_HUMAN",232,"O00410","IPO5_HUMAN","Importin-5","mp5","IPO5"]
["23.8023","23.3164","23.6307","23.3094","23.0186","23.4831",{"$nulls":3},"antigen processing and presentation of peptide antigen via MHC class I;calcium-mediated signaling using intracellular calcium source;ER to Golgi vesicle-mediated transport;execution phase of apoptosis;intracellular protein transport;negative regulation of endoplasmic reticulum calcium ion concentration;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cytosolic calcium ion concentration;positive regulation of ER-associated ubiquitin-dependent protein catabolic process;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial calcium ion concentration;positive regulation of retrograde protein transport, ER to cytosol;protein localization to endoplasmic reticulum exit site;spermatogenesis","MHC class I protein binding;protein complex binding","clathrin-coated vesicle;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi cisterna membrane;integral component of lumenal side of endoplasmic reticulum membrane;integral component of plasma membrane;lipid droplet;membrane;mitochondrion;perinuclear endoplasmic reticulum","Human papillomavirus infection;Protein processing in endoplasmic reticulum",null,null,11,11,11,"38.6","38.6","38.6","27.991",0,"57.469",1867000000,58,"0.729156",1,"0.312786","1.59213","sp|P51572|BAP31_HUMAN;tr|C9JSP1|C9JSP1_HUMAN;tr|C9JQ75|C9JQ75_HUMAN;tr|C9J0M4|C9J0M4_HUMAN;tr|C9JMD7|C9JMD7_HUMAN;tr|C9JM14|C9JM14_HUMAN","sp|P51572|BAP31_HUMAN;tr|C9JSP1|C9JSP1_HUMAN;tr|C9JQ75|C9JQ75_HUMAN;tr|C9J0M4|C9J0M4_HUMAN;tr|C9JMD7|C9JMD7_HUMAN",1741,"P51572","BAP31_HUMAN","B-cell receptor-associated protein 31","ap31;CR-associated protein 31","BCAP31"]
["23.0772","21.951","22.326","22.5661","21.6891","22.1649",{"$nulls":3},"carbohydrate phosphorylation;cellular carbohydrate metabolic process;fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;glycerol metabolic process;innate immune response;negative regulation of MDA-5 signaling pathway;regulation of innate immune response","ATP binding;FAD-AMP lyase (cyclizing) activity;glycerone kinase activity;metal ion binding;triokinase activity","cytosol;extracellular exosome;nucleus","Carbon metabolism;Fructose and mannose metabolism;Glycerolipid metabolism;Metabolic pathways;RIG-I-like receptor signaling pathway",null,null,19,19,19,51,51,51,"58.946",0,"204.35",1615500000,124,"0.303833",1,"0.311341","0.746626","sp|Q3LXA3|TKFC_HUMAN;tr|A0A087WUL0|A0A087WUL0_HUMAN;tr|H0YCY6|H0YCY6_HUMAN;tr|I3L252|I3L252_HUMAN;tr|E9PJG8|E9PJG8_HUMAN;tr|E9PQR1|E9PQR1_HUMAN","sp|Q3LXA3|TKFC_HUMAN;tr|A0A087WUL0|A0A087WUL0_HUMAN;tr|H0YCY6|H0YCY6_HUMAN;tr|I3L252|I3L252_HUMAN",2739,"Q3LXA3","TKFC_HUMAN","Triokinase/FMN cyclase {ECO:0000312|HGNC:HGNC:24552}",null,"TKFC"]
["20.6787","18.8141","20.197","19.785","18.6516","20.3234",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;aorta morphogenesis;auditory receptor cell stereocilium organization;cargo loading into COPII-coated vesicle;cochlear nucleus development;COPII vesicle coating;coronary artery morphogenesis;ER to Golgi vesicle-mediated transport;intracellular protein transport;lung lobe morphogenesis;neural tube closure;outflow tract morphogenesis;pulmonary artery morphogenesis;regulation of cargo loading into COPII-coated vesicle;regulation of establishment of planar polarity involved in neural tube closure","zinc ion binding","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane","Protein processing in endoplasmic reticulum",null,null,14,14,13,17,17,"16.3","137.42",0,"141.59",316030000,48,"0.155665",1,"0.309905","0.415983","sp|O95487|SC24B_HUMAN","sp|O95487|SC24B_HUMAN",764,"O95487","SC24B_HUMAN","Protein transport protein Sec24B {ECO:0000305}",null,"SEC24B"]
["23.5384","23.0629","22.6642","22.9994","22.7333","22.6071",{"$nulls":3},"cytolysis;'de novo' GDP-L-fucose biosynthetic process;GDP-mannose metabolic process;leukocyte cell-cell adhesion","coenzyme binding;electron transfer activity;GDP-4-dehydro-D-rhamnose reductase activity;GDP-L-fucose synthase activity;identical protein binding;isomerase activity","cytoplasm;cytosol;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Fructose and mannose metabolism;Metabolic pathways",null,null,10,10,10,"46.7","46.7","46.7","35.892",0,"64.748",1254100000,46,"0.482807",1,"0.308587","1.11061","sp|Q13630|FCL_HUMAN;tr|E9PKL9|E9PKL9_HUMAN;tr|E9PP14|E9PP14_HUMAN;tr|A0A0J9YX13|A0A0J9YX13_HUMAN;tr|E9PLH9|E9PLH9_HUMAN;tr|E9PP60|E9PP60_HUMAN;tr|H0YE90|H0YE90_HUMAN;tr|H0YCP7|H0YCP7_HUMAN","sp|Q13630|FCL_HUMAN;tr|E9PKL9|E9PKL9_HUMAN;tr|E9PP14|E9PP14_HUMAN;tr|A0A0J9YX13|A0A0J9YX13_HUMAN;tr|E9PLH9|E9PLH9_HUMAN",2398,"Q13630","FCL_HUMAN","GDP-L-fucose synthase",null,"TSTA3"]
["23.951","23.1657","22.7528","23.7891","22.643","22.5172",{"$nulls":3},"epithelial cell differentiation;platelet degranulation","cadherin binding","cytosol;extracellular exosome;extracellular region;vesicle",{"$nulls":3},11,11,11,"70.4","70.4","70.4","22.391",0,"191.41",1386600000,62,"0.223546",1,"0.306777","0.572445","sp|P37802|TAGL2_HUMAN;tr|X6RJP6|X6RJP6_HUMAN;tr|C9J5W6|C9J5W6_HUMAN;sp|Q9UI15|TAGL3_HUMAN","sp|P37802|TAGL2_HUMAN;tr|X6RJP6|X6RJP6_HUMAN",1497,"P37802","TAGL2_HUMAN","Transgelin-2",null,"TAGLN2"]
["21.8835","21.0505","19.9263","21.4625","20.7706","19.7078",{"$nulls":3},"ER to Golgi vesicle-mediated transport;protein transport;retrograde transport, endosome to Golgi;vesicle docking involved in exocytosis;vesicle fusion;vesicle targeting","cadherin binding;protein-cysteine S-palmitoyltransferase activity;SNAP receptor activity;SNARE binding","apical dendrite;basal dendrite;cytoplasm;cytoplasmic vesicle membrane;cytosol;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment membrane;endosome;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of plasma membrane;mitochondrion;neuronal cell body;SNARE complex;transport vesicle","SNARE interactions in vesicular transport",null,null,6,6,6,"38.4","38.4","38.4","22.417",0,"24.232",376730000,22,"0.149688",1,"0.306432","0.401681","sp|O15498|YKT6_HUMAN;tr|H7C3K7|H7C3K7_HUMAN","sp|O15498|YKT6_HUMAN",381,"O15498","YKT6_HUMAN","Synaptobrevin homolog YKT6",null,"YKT6"]
["24.8803","23.3476","24.2134","24.3068","23.1517","24.0685",{"$nulls":3},"beta-catenin destruction complex disassembly;branching morphogenesis of an epithelial tube;cell cycle;cell division;circadian regulation of gene expression;dephosphorylation;entrainment of circadian clock by photoperiod;glycogen metabolic process;lung development;negative regulation of protein binding;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;protein dephosphorylation;regulation of canonical Wnt signaling pathway;regulation of circadian rhythm;regulation of glycogen biosynthetic process;regulation of glycogen catabolic process;regulation of translational initiation by eIF2 alpha dephosphorylation","cadherin binding involved in cell-cell adhesion;metal ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein complex binding;protein phosphatase 1 binding;protein serine/threonine phosphatase activity;ribonucleoprotein complex binding","cell-cell adherens junction;cytoplasm;cytosol;dendritic spine;extracellular exosome;glycogen granule;nucleolus;nucleoplasm;nucleus;perikaryon;plasma membrane;protein phosphatase type 1 complex;PTW/PP1 phosphatase complex","Adrenergic signaling in cardiomyocytes;Alcoholism;Amphetamine addiction;cAMP signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Dopaminergic synapse;Focal adhesion;Herpes simplex virus 1 infection;Hippo signaling pathway;Inflammatory mediator regulation of TRP channels;Insulin resistance;Insulin signaling pathway;Long-term potentiation;mRNA surveillance pathway;Oocyte meiosis;Oxytocin signaling pathway;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Vascular smooth muscle contraction",null,null,15,15,5,"52.4","52.4","14.5","37.512",0,"213.81",3197900000,179,"0.208254",1,"0.304775","0.538058","sp|P62136|PP1A_HUMAN;tr|E9PMD7|E9PMD7_HUMAN;tr|F5H1L6|F5H1L6_HUMAN;tr|F5H037|F5H037_HUMAN;tr|F8WE71|F8WE71_HUMAN;tr|H0Y3Y6|H0Y3Y6_HUMAN;tr|F8W1A0|F8W1A0_HUMAN","sp|P62136|PP1A_HUMAN;tr|E9PMD7|E9PMD7_HUMAN",1954,"P62136","PP1A_HUMAN","Serine/threonine-protein phosphatase PP1-alpha catalytic subunit","P-1A","PPP1CA"]
["20.9329","20.1016","20.1336","20.7901","19.5442","19.9214",{"$nulls":3},"chemical synaptic transmission",null,"extracellular exosome;integral component of membrane;integral component of plasma membrane;integral component of synaptic vesicle membrane;melanosome;secretory granule",{"$nulls":3},4,1,1,"22.4","9.7","9.7","28.565",0,"14.532",111030000,27,"0.265058",1,"0.304165","0.663706","sp|Q16563|SYPL1_HUMAN;tr|H7C4J8|H7C4J8_HUMAN","sp|Q16563|SYPL1_HUMAN",2674,"Q16563","SYPL1_HUMAN","Synaptophysin-like protein 1",null,"SYPL1"]
["20.7392","20.0449","20.9203","20.1718","19.5278","21.0929",{"$nulls":3},"bicellular tight junction assembly;establishment of cell polarity;positive regulation of protein complex assembly;protein localization to adherens junction","cadherin binding;protein complex scaffold activity;protein domain specific binding;protein heterodimerization activity;signaling adaptor activity","adherens junction;bicellular tight junction;cell junction;MPP7-DLG1-LIN7 complex;nucleoplasm",{"$nulls":3},19,19,19,"41.1","41.1","41.1","65.523",0,"95.565",600640000,75,"0.225616",1,"0.303949","0.577064","sp|Q5T2T1|MPP7_HUMAN;tr|S4R337|S4R337_HUMAN;tr|U5GXS2|U5GXS2_HUMAN","sp|Q5T2T1|MPP7_HUMAN;tr|S4R337|S4R337_HUMAN;tr|U5GXS2|U5GXS2_HUMAN",2870,"Q5T2T1","MPP7_HUMAN","MAGUK p55 subfamily member 7",null,"MPP7"]
["19.7145","19.0951","18.5691","19.4417","18.3021","18.7243",{"$nulls":3},"cellular response to ionizing radiation;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;double-strand break repair;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of peptidyl-serine phosphorylation;positive regulation of peptidyl-threonine phosphorylation;positive regulation of protein autophosphorylation;telomere maintenance via telomerase","ankyrin repeat binding;cadherin binding;enzyme binding;macromolecular complex binding","CCR4-NOT complex;cell-cell adherens junction;cytoplasm;cytoskeleton;cytosol;nuclear heterochromatin;nucleus",{"$nulls":3},31,31,31,"27.8","27.8","27.8","181.79",0,"136.66",575290000,85,"0.257314",1,"0.303564","0.646893","sp|Q9C0C2|TB182_HUMAN;tr|E9PKK0|E9PKK0_HUMAN;tr|E9PKE7|E9PKE7_HUMAN","sp|Q9C0C2|TB182_HUMAN",4348,"Q9C0C2","TB182_HUMAN","182 kDa tankyrase-1-binding protein",null,"TNKS1BP1"]
["19.6271","20.0383","21.2005","18.6097","19.6726","21.6748",{"$nulls":3},"multicellular organism development;post-translational protein modification;protein ubiquitination",null,"Cul4-RING E3 ubiquitin ligase complex;cytoplasm;cytosol;nuclear body;nuclear matrix;nucleoplasm;protein complex",{"$nulls":3},8,8,8,"28.4","28.4","28.4","38.926",0,"22.484",275890000,17,"0.107843",1,"0.302958","0.298603","sp|P61962|DCAF7_HUMAN;tr|A0A087WWI6|A0A087WWI6_HUMAN","sp|P61962|DCAF7_HUMAN;tr|A0A087WWI6|A0A087WWI6_HUMAN",1945,"P61962","DCAF7_HUMAN","DDB1- and CUL4-associated factor 7",null,"DCAF7"]
["22.1098","20.4916","21.4075","21.354","20.4927","21.2564",{"$nulls":4},"GTPase activator activity;metal ion binding",{"$nulls":4},12,12,10,"49.9","49.9","44.2","42.153",0,"66.209",590040000,32,"0.216781",1,"0.301984","0.557287","tr|A0A0D9SF70|A0A0D9SF70_HUMAN;tr|G5E9L0|G5E9L0_HUMAN;sp|Q8N6H7|ARFG2_HUMAN;tr|E9PQP3|E9PQP3_HUMAN;tr|H0YDN9|H0YDN9_HUMAN;tr|E9PIY6|E9PIY6_HUMAN;tr|E9PMU9|E9PMU9_HUMAN;tr|E9PMR9|E9PMR9_HUMAN;tr|E9PM63|E9PM63_HUMAN;tr|H0YDX1|H0YDX1_HUMAN;tr|E9PJT7|E9PJT7_HUMAN;tr|E9PK28|E9PK28_HUMAN;tr|E9PM18|E9PM18_HUMAN;tr|E9PNY8|E9PNY8_HUMAN;tr|H0YF45|H0YF45_HUMAN","tr|A0A0D9SF70|A0A0D9SF70_HUMAN;tr|G5E9L0|G5E9L0_HUMAN;sp|Q8N6H7|ARFG2_HUMAN;tr|E9PQP3|E9PQP3_HUMAN;tr|H0YDN9|H0YDN9_HUMAN",3424,"A0A0D9SF70","A0A0D9SF70_HUMAN",null,null,"ARFGAP2"]
["20.7795","21.0077","20.245","20.3793","20.2822","20.4686",{"$nulls":4},"cadherin binding;structural molecule activity","basement membrane;extracellular exosome",{"$nulls":3},14,14,14,"37.5","37.5","37.5","57.13",0,"38.871",502200000,52,"0.576417",1,"0.300716","1.29437","sp|O00515|LAD1_HUMAN;tr|E9PDI4|E9PDI4_HUMAN;tr|A0A0J9YYF6|A0A0J9YYF6_HUMAN;tr|A0A0J9YW63|A0A0J9YW63_HUMAN;tr|A0A0J9YVY2|A0A0J9YVY2_HUMAN;tr|H0Y901|H0Y901_HUMAN","sp|O00515|LAD1_HUMAN;tr|E9PDI4|E9PDI4_HUMAN",250,"O00515","LAD1_HUMAN","Ladinin-1","ad-1","LAD1"]
["24.9869","23.7724","24.8361","24.6159","23.3677","24.7113",{"$nulls":3},"apoptotic process;ATP generation from poly-ADP-D-ribose;cellular response to amyloid-beta;cellular response to DNA damage stimulus;cellular response to insulin stimulus;cellular response to oxidative stress;cellular response to zinc ion;DNA damage response, detection of DNA damage;DNA ligation involved in DNA repair;DNA repair;double-strand break repair;double-strand break repair via homologous recombination;global genome nucleotide-excision repair;lagging strand elongation;macrophage differentiation;mitochondrial DNA metabolic process;mitochondrial DNA repair;mitochondrion organization;negative regulation of ATP biosynthetic process;negative regulation of telomere maintenance via telomere lengthening;negative regulation of transcription from RNA polymerase II promoter;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;peptidyl-serine ADP-ribosylation;positive regulation of cardiac muscle hypertrophy;positive regulation of intracellular estrogen receptor signaling pathway;positive regulation of mitochondrial depolarization;positive regulation of myofibroblast differentiation;positive regulation of neuron death;positive regulation of single strand break repair;positive regulation of SMAD protein import into nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription regulatory region DNA binding;protein ADP-ribosylation;protein autoprocessing;protein modification process;protein poly-ADP-ribosylation;regulation of catalytic activity;regulation of cellular protein localization;regulation of DNA methylation;regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;regulation of SMAD protein complex assembly;response to aldosterone;response to gamma radiation;signal transduction involved in regulation of gene expression;telomere maintenance;transcription from RNA polymerase II promoter;transforming growth factor beta receptor signaling pathway","DNA binding;DNA ligase (ATP) activity;enzyme binding;estrogen receptor binding;histone deacetylase binding;identical protein binding;NAD binding;NAD+ ADP-ribosyltransferase activity;protein ADP-ribosylase activity;protein kinase binding;protein N-terminus binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;R-SMAD binding;transcription factor binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;zinc ion binding","membrane;mitochondrion;nuclear chromosome, telomeric region;nuclear envelope;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;transcription factor complex","Apoptosis;Base excision repair;Necroptosis;NF-kappa B signaling pathway",null,null,58,58,58,"60.7","60.7","60.7","113.08",0,"323.31",44063000000,1565,"0.200217",1,"0.300138","0.519802","sp|P09874|PARP1_HUMAN;tr|Q5VX84|Q5VX84_HUMAN;tr|Q5VX85|Q5VX85_HUMAN","sp|P09874|PARP1_HUMAN",1000,"P09874","PARP1_HUMAN","Poly [ADP-ribose] polymerase 1","ARP-1","PARP1"]
["21.9191","20.8224","21.9297","21.6896","20.5942","21.4886",{"$nulls":3},"carbohydrate metabolic process;isocitrate metabolic process;tricarboxylic acid cycle","ATP binding;isocitrate dehydrogenase (NAD+) activity;magnesium ion binding;NAD binding","mitochondrial matrix;mitochondrion;nucleolus;nucleoplasm","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways",null,null,8,8,8,"32.1","32.1","32.1","42.794",0,"96.617",462430000,35,"0.236532",1,"0.299611","0.601304","sp|P51553|IDH3G_HUMAN;tr|G5E9Q7|G5E9Q7_HUMAN;tr|E7EQB8|E7EQB8_HUMAN;tr|E9PF84|E9PF84_HUMAN;tr|H7C1W2|H7C1W2_HUMAN;tr|H0Y5Q7|H0Y5Q7_HUMAN","sp|P51553|IDH3G_HUMAN;tr|G5E9Q7|G5E9Q7_HUMAN;tr|E7EQB8|E7EQB8_HUMAN;tr|E9PF84|E9PF84_HUMAN;tr|H7C1W2|H7C1W2_HUMAN",1738,"P51553","IDH3G_HUMAN","Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial",null,"IDH3G"]
["21.889","19.5313","21.5057","20.8521","19.7315","21.4469",{"$nulls":3},"calcium ion regulated exocytosis;cerebellum development;fat cell differentiation;response to ethanol;UV protection;zymogen granule exocytosis","calcium ion binding;identical protein binding","bleb;cytoplasm;extracellular exosome;Golgi apparatus;Golgi lumen;late endosome;membrane;plasma membrane",{"$nulls":3},12,12,12,"45.3","45.3","45.3","41.806",0,"98.742",351630000,32,"0.12301",1,"0.298496","0.336598","sp|Q9BRK5|CAB45_HUMAN;tr|H0Y3T6|H0Y3T6_HUMAN;tr|G3V1E2|G3V1E2_HUMAN","sp|Q9BRK5|CAB45_HUMAN;tr|H0Y3T6|H0Y3T6_HUMAN;tr|G3V1E2|G3V1E2_HUMAN",4164,"Q9BRK5","CAB45_HUMAN","45 kDa calcium-binding protein","ab45","SDF4"]
["19.9566","18.22","17.3596","19.2295","17.5619","17.8511",{"$nulls":3},"cell cycle;cell proliferation;DNA repair;histone monoubiquitination;histone ubiquitination;maintenance of DNA methylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cellular protein metabolic process;positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;positive regulation of transcription from RNA polymerase II promoter;protein autoubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of methylation-dependent chromatin silencing;transcription, DNA-templated","DNA binding transcription factor activity;hemi-methylated DNA-binding;histone binding;identical protein binding;methylated histone binding;methyl-CpG binding;nucleosomal histone binding;proximal promoter sequence-specific DNA binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity;zinc ion binding","euchromatin;heterochromatin;nuclear chromatin;nuclear heterochromatin;nuclear matrix;nucleus;replication fork",{"$nulls":3},14,14,14,"24.8","24.8","24.8","89.813",0,"48.597",211590000,36,"0.117746",1,"0.297906","0.323499","sp|Q96T88|UHRF1_HUMAN;tr|A0A087WVR3|A0A087WVR3_HUMAN;tr|A0A087WTW0|A0A087WTW0_HUMAN;tr|A0A087WWG9|A0A087WWG9_HUMAN","sp|Q96T88|UHRF1_HUMAN;tr|A0A087WVR3|A0A087WVR3_HUMAN;tr|A0A087WTW0|A0A087WTW0_HUMAN;tr|A0A087WWG9|A0A087WWG9_HUMAN",4054,"Q96T88","UHRF1_HUMAN","E3 ubiquitin-protein ligase UHRF1",null,"UHRF1"]
["17.1729","18.3886","17.2597","16.2941","18.5898","17.0487",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;rRNA transcription;transcription from RNA polymerase III promoter;transcription initiation from RNA polymerase III promoter;transcription, DNA-templated;tRNA transcription;tRNA transcription from RNA polymerase III promoter","RNA polymerase III type 1 promoter sequence-specific DNA binding;RNA polymerase III type 2 promoter sequence-specific DNA binding;transcription factor activity, RNA polymerase III transcription factor binding","intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;transcription factor TFIIIC complex",{"$nulls":3},32,32,32,19,19,19,"238.87",0,"124.81",896400000,106,"0.140408",1,"0.296155","0.37928","sp|Q12789|TF3C1_HUMAN;tr|H3BRD0|H3BRD0_HUMAN;tr|H3BU37|H3BU37_HUMAN;tr|H3BU55|H3BU55_HUMAN;tr|I3L1Z3|I3L1Z3_HUMAN","sp|Q12789|TF3C1_HUMAN",2259,"Q12789","TF3C1_HUMAN","General transcription factor 3C polypeptide 1",null,"GTF3C1"]
["20.2344","18.4816","20.1007","20.1521","17.9347","19.8447",{"$nulls":3},"regulation of transcription from RNA polymerase II promoter;skeletal muscle cell differentiation;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;transcription, DNA-templated","DNA-directed 5'-3' RNA polymerase activity;RNA polymerase II transcription cofactor activity;transcription coactivator activity;ubiquitin protein ligase activity","mediator complex;nucleoplasm;ubiquitin ligase complex",{"$nulls":3},3,3,3,"15.1","15.1","15.1","23.222",0,"9.7803",181250000,21,"0.120455",1,"0.295087","0.330252","sp|Q9H944|MED20_HUMAN;tr|A6PVP4|A6PVP4_HUMAN;tr|B7ZBQ3|B7ZBQ3_HUMAN;tr|A0A087X1F4|A0A087X1F4_HUMAN;tr|B7ZBQ1|B7ZBQ1_HUMAN","sp|Q9H944|MED20_HUMAN;tr|A6PVP4|A6PVP4_HUMAN;tr|B7ZBQ3|B7ZBQ3_HUMAN;tr|A0A087X1F4|A0A087X1F4_HUMAN",4532,"Q9H944","MED20_HUMAN","Mediator of RNA polymerase II transcription subunit 20",null,"MED20"]
["18.4363","16.5739","18.1606","17.4502","16.4749","18.3657",{"$nulls":3},"fertilization;intracellular transport of virus;learning;mitotic nuclear envelope disassembly;mRNA export from nucleus;nucleocytoplasmic transport;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of nucleocytoplasmic transport;tRNA export from nucleus;viral process;viral transcription",null,"centrosome;cytosol;host cell;membrane;nuclear envelope;nuclear membrane;nuclear pore;nucleoplasm;nucleus","RNA transport",null,null,5,5,5,"15.2","15.2","15.2","59.573",0,"21.507",59211000,10,"0.135831",1,"0.29332","0.368139","sp|Q9NRG9|AAAS_HUMAN;tr|H3BU82|H3BU82_HUMAN;tr|F8VZ44|F8VZ44_HUMAN;tr|F8VUB6|F8VUB6_HUMAN","sp|Q9NRG9|AAAS_HUMAN;tr|H3BU82|H3BU82_HUMAN;tr|F8VZ44|F8VZ44_HUMAN",4691,"Q9NRG9","AAAS_HUMAN","Aladin",null,"AAAS"]
["18.6073","17.448","17.954","18.4182","17.4718","17.2409",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;RNA export from nucleus;termination of RNA polymerase II transcription","ATP binding;ATP-dependent RNA helicase activity;RNA binding","catalytic step 2 spliceosome;cytoplasm;membrane;nucleoplasm;nucleus","Spliceosome",null,null,10,10,10,"9.8","9.8","9.8","140.5",0,"57.887",165500000,30,"0.233602",1,"0.292816","0.594818","sp|Q92620|PRP16_HUMAN;tr|H3BQT9|H3BQT9_HUMAN;tr|H3BV01|H3BV01_HUMAN;tr|J3KRT1|J3KRT1_HUMAN;tr|J3KTG2|J3KTG2_HUMAN","sp|Q92620|PRP16_HUMAN",3695,"Q92620","PRP16_HUMAN","Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16",null,"DHX38"]
["19.6666","17.9062","18.9188","18.9911","17.9788","18.6469",{"$nulls":3},"nuclear export",null,"nucleus",{"$nulls":3},29,29,29,"30.9","30.9","30.9","122.95",0,"269.92",3449900000,213,"0.188941",1,"0.291609","0.493959","sp|O60524|NEMF_HUMAN;tr|G3V5V3|G3V5V3_HUMAN;tr|G3V4D9|G3V4D9_HUMAN;tr|G3V547|G3V547_HUMAN","sp|O60524|NEMF_HUMAN;tr|G3V5V3|G3V5V3_HUMAN",503,"O60524","NEMF_HUMAN","Nuclear export mediator factor NEMF",null,"NEMF"]
["18.0751","17.0007","16.8998","17.7229","16.7171","16.6632",{"$nulls":3},"actin filament network formation;establishment or maintenance of cell polarity;establishment or maintenance of monopolar cell polarity;maintenance of cell polarity;negative regulation of barbed-end actin filament capping;positive regulation of cell migration;positive regulation of extracellular matrix disassembly;positive regulation of lamellipodium assembly;positive regulation of lamellipodium organization;positive regulation of ruffle assembly;wound healing, spreading of cells","phospholipid binding;protein complex binding","actin cytoskeleton;cell leading edge;cytoplasm;extrinsic component of cytoplasmic side of plasma membrane;intermediate filament cytoskeleton;lamellipodium;macropinosome;membrane;plasma membrane;ruffle",{"$nulls":3},6,6,6,"6.3","6.3","6.3","154.69",0,"26.446",109800000,25,"0.222561",1,"0.290873","0.570241","sp|Q6F5E8|LR16C_HUMAN;tr|R4GMZ7|R4GMZ7_HUMAN","sp|Q6F5E8|LR16C_HUMAN",2950,"Q6F5E8","CARL2_HUMAN","Capping protein, Arp2/3 and myosin-I linker protein 2 {ECO:0000303|PubMed:19846667}",null,"CARMIL2"]
["20.9029","20.4482","20.8196","20.4619","19.9209","20.919",{"$nulls":4},"nucleic acid binding","nucleus",{"$nulls":3},2,2,2,"21.2","21.2","21.2","16.14",0,"13.018",124570000,9,"0.379471",1,"0.289605","0.903448","tr|E7EVL6|E7EVL6_HUMAN;tr|C9JZE3|C9JZE3_HUMAN;tr|C9JYJ8|C9JYJ8_HUMAN;sp|Q9BWE0|REPI1_HUMAN","tr|E7EVL6|E7EVL6_HUMAN;tr|C9JZE3|C9JZE3_HUMAN;tr|C9JYJ8|C9JYJ8_HUMAN;sp|Q9BWE0|REPI1_HUMAN",4278,"E7EVL6","E7EVL6_HUMAN",null,null,"REPIN1"]
["18.7517","17.7737","17.6375","18.3241","17.5076","17.4718",{"$nulls":3},"biotin metabolic process;gluconeogenesis;lipid metabolic process;negative regulation of gene expression;positive regulation by host of viral process;positive regulation by host of viral release from host cell;pyruvate metabolic process;viral RNA genome packaging","ATP binding;biotin binding;biotin carboxylase activity;identical protein binding;metal ion binding;pyruvate carboxylase activity","cytoplasm;cytosol;mitochondrial matrix;mitochondrion","Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways;Pyruvate metabolism",null,null,15,15,15,"17.9","17.9","17.9","129.63",0,"39.309",291330000,38,"0.253979",1,"0.286485","0.639625","sp|P11498|PYC_HUMAN;tr|E9PRE7|E9PRE7_HUMAN;tr|E9PS68|E9PS68_HUMAN","sp|P11498|PYC_HUMAN",1050,"P11498","PYC_HUMAN","Pyruvate carboxylase, mitochondrial",null,"PC"]
["19.7217","20.8974","20.9818","19.8015","20.133","20.808",{"$nulls":3},"mitochondrial respiratory chain complex I assembly","calmodulin binding","mitochondrial inner membrane;mitochondrial membrane;mitochondrion","Thermogenesis",null,null,5,5,5,"29.7","29.7","29.7","20.266",0,"13.44",165610000,15,"0.221907",1,"0.286146","0.568779","sp|Q9P032|NDUF4_HUMAN","sp|Q9P032|NDUF4_HUMAN",4900,"Q9P032","NDUF4_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4",null,"NDUFAF4"]
["19.5856","18.7691","18.8194","19.0317","18.2869","18.9979",{"$nulls":5},"Golgi apparatus",{"$nulls":3},5,5,5,"6.2","6.2","6.2","114.16",0,"49.116",436810000,47,"0.32771",1,"0.285891","0.796756","tr|A0A0A6YYL4|A0A0A6YYL4_HUMAN;sp|Q9Y3D7|TIM16_HUMAN;tr|I3L1U7|I3L1U7_HUMAN;tr|I3L0X9|I3L0X9_HUMAN;tr|I3L3T0|I3L3T0_HUMAN;sp|P57737|CORO7_HUMAN","tr|A0A0A6YYL4|A0A0A6YYL4_HUMAN;sp|Q9Y3D7|TIM16_HUMAN;tr|I3L1U7|I3L1U7_HUMAN;tr|I3L0X9|I3L0X9_HUMAN;tr|I3L3T0|I3L3T0_HUMAN",5454,"A0A0A6YYL4","A0A0A6YYL4_HUMAN","Coronin {ECO:0000256|RuleBase:RU280818}",null,"CORO7-PAM16"]
["22.64","18.211","19.5096","19.5505","20.271","19.6818",{"$nulls":3},"cell division;microtubule-based movement;mitotic metaphase plate congression;mitotic sister chromatid segregation;mitotic spindle assembly;spermatogenesis","ATP binding;ATPase activity;microtubule binding;microtubule motor activity","early endosome;kinesin complex;membrane;microtubule;microtubule organizing center;nucleus;spindle",{"$nulls":3},11,11,11,22,22,22,"73.747",0,"61.401",1235300000,50,"0.0753246",1,"0.285722","0.214338","sp|Q9BW19|KIFC1_HUMAN;tr|A0A087X1W5|A0A087X1W5_HUMAN;tr|A2AB20|A2AB20_HUMAN","sp|Q9BW19|KIFC1_HUMAN",4267,"Q9BW19","KIFC1_HUMAN","Kinesin-like protein KIFC1",null,"KIFC1"]
["18.8131","17.3219","17.511","19.4609","16.7228","16.6095",{"$nulls":4},"RNA binding",{"$nulls":4},5,5,5,"6.7","6.7","6.7","129.98",0,"31.675",134370000,14,"0.0975884",1,"0.28428","0.272465","sp|Q96EV2|RBM33_HUMAN;tr|H0Y3K4|H0Y3K4_HUMAN;tr|H7BXM6|H7BXM6_HUMAN;tr|A8MTF7|A8MTF7_HUMAN;tr|H7C0H2|H7C0H2_HUMAN","sp|Q96EV2|RBM33_HUMAN;tr|H0Y3K4|H0Y3K4_HUMAN",3865,"Q96EV2","RBM33_HUMAN","RNA-binding protein 33",null,"RBM33"]
["27.0957","25.3813","25.8097","25.7108","25.474","26.249",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},12,12,2,"50.5","50.5","14.5","22.975",0,"321.64",11818000000,562,"0.193372",1,"0.284265","0.504148","tr|X1WI28|X1WI28_HUMAN;sp|P27635|RL10_HUMAN;tr|A0A087WV22|A0A087WV22_HUMAN;tr|H7C123|H7C123_HUMAN;tr|H7C2C5|H7C2C5_HUMAN;tr|B8A6G2|B8A6G2_HUMAN;tr|A6QRI9|A6QRI9_HUMAN;sp|Q96L21|RL10L_HUMAN;tr|H7C2U2|H7C2U2_HUMAN","tr|X1WI28|X1WI28_HUMAN;sp|P27635|RL10_HUMAN;tr|A0A087WV22|A0A087WV22_HUMAN;tr|H7C123|H7C123_HUMAN;tr|H7C2C5|H7C2C5_HUMAN",1324,"X1WI28","X1WI28_HUMAN",null,null,"RPL10"]
["26.5375","24.6935","26.0562","26.2811","24.2542","25.9042",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;pore complex assembly;positive regulation of protein localization to Cajal body;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;toxin transport","ATP binding;protein binding involved in protein folding;RNA binding;unfolded protein binding","cell body;chaperonin-containing T-complex;cytoskeleton;cytosol;extracellular exosome;microtubule;myelin sheath;plasma membrane;zona pellucida receptor complex",{"$nulls":3},35,35,35,"69.2","69.2","69.2","60.533",0,"323.31",18307000000,503,"0.124229",1,"0.282578","0.339619","sp|P49368|TCPG_HUMAN;tr|B4DUR8|B4DUR8_HUMAN;tr|E9PRC8|E9PRC8_HUMAN;tr|Q5SZX6|Q5SZX6_HUMAN;tr|Q5SZX9|Q5SZX9_HUMAN;tr|Q5SZW8|Q5SZW8_HUMAN;tr|E9PQ35|E9PQ35_HUMAN;tr|E9PM09|E9PM09_HUMAN","sp|P49368|TCPG_HUMAN;tr|B4DUR8|B4DUR8_HUMAN",1655,"P49368","TCPG_HUMAN","T-complex protein 1 subunit gamma","CP-1-gamma","CCT3"]
["23.1404","22.111","22.8013","22.2581","22.1108","22.8382",{"$nulls":3},"clathrin coat assembly;endocytosis","cadherin binding;clathrin binding;lipid binding","clathrin-coated vesicle;cytosol;Golgi apparatus;intracellular membrane-bounded organelle;membrane;nucleoplasm;perinuclear region of cytoplasm",{"$nulls":3},12,12,12,"25.4","25.4","25.4","68.259",0,"144.47",1465700000,74,"0.305736",1,"0.281883","0.750645","sp|Q14677|EPN4_HUMAN;tr|H0YD52|H0YD52_HUMAN","sp|Q14677|EPN4_HUMAN",2490,"Q14677","EPN4_HUMAN","Clathrin interactor 1",null,"CLINT1"]
["20.6174","19.1717","19.9181","19.5823","19.5731","19.7122",{"$nulls":3},"arginine biosynthetic process;argininosuccinate metabolic process;aspartate metabolic process;cellular response to laminar fluid shear stress;circadian rhythm;citrulline metabolic process;negative regulation of leukocyte cell-cell adhesion;positive regulation of nitric oxide biosynthetic process;urea cycle","amino acid binding;argininosuccinate synthase activity;ATP binding;identical protein binding;RNA binding","cytoplasm;cytosol;extracellular exosome;mitochondrion;myelin sheath","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Fluid shear stress and atherosclerosis;Metabolic pathways",null,null,14,14,14,"34.2","34.2","34.2","46.53",0,"100.78",375590000,29,"0.266379",1,"0.279838","0.666566","sp|P00966|ASSY_HUMAN;tr|Q5T6L6|Q5T6L6_HUMAN;tr|Q5T6L5|Q5T6L5_HUMAN","sp|P00966|ASSY_HUMAN;tr|Q5T6L6|Q5T6L6_HUMAN",838,"P00966","ASSY_HUMAN","Argininosuccinate synthase {ECO:0000305}",null,"ASS1"]
["21.3305","18.6583","21.0634","19.8475","19.3","21.0676",{"$nulls":3},"maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","ribonucleoprotein complex binding","chromosome;cytosol;nucleolus;nucleoplasm;nucleus;preribosome, large subunit precursor",{"$nulls":3},23,23,23,"42.6","42.6","42.6","66.077",0,"179.37",3100000000,187,"0.100412",1,"0.278992","0.2797","tr|B5MCF9|B5MCF9_HUMAN;sp|O00541|PESC_HUMAN;tr|B3KXD6|B3KXD6_HUMAN;tr|H7C267|H7C267_HUMAN;tr|H7BYY8|H7BYY8_HUMAN","tr|B5MCF9|B5MCF9_HUMAN;sp|O00541|PESC_HUMAN;tr|B3KXD6|B3KXD6_HUMAN",251,"B5MCF9","B5MCF9_HUMAN","Pescadillo homolog {ECO:0000256|HAMAP-Rule:MF_03028}"]
["24.9433","23.4935","24.4626","24.5382","23.2706","24.26",{"$nulls":3},"cell cycle;cell division;cilium assembly;neuron projection development;regulation of L-glutamate transport;regulation of protein localization;smoothened signaling pathway;spermatogenesis","cadherin binding;enzyme regulator activity;GTP binding;identical protein binding;protein complex scaffold activity","actin cytoskeleton;axoneme;ciliary membrane;cleavage furrow;condensed chromosome kinetochore;cytoplasm;cytosol;exocyst;extracellular exosome;midbody;myelin sheath;non-motile cilium;nucleolus;nucleus;perinuclear region of cytoplasm;photoreceptor connecting cilium;septin complex;sperm annulus;spindle;synapse","Bacterial invasion of epithelial cells",null,null,19,19,19,"63.2","63.2","63.2","41.487",0,"323.31",3956300000,155,"0.183832",1,"0.276876","0.482158","sp|Q15019|SEPT2_HUMAN;tr|B5MCX3|B5MCX3_HUMAN;tr|C9J2Q4|C9J2Q4_HUMAN;tr|H7C2Y0|H7C2Y0_HUMAN;tr|C9JB25|C9JB25_HUMAN;tr|C9J938|C9J938_HUMAN;tr|H7C310|H7C310_HUMAN;tr|C9IY94|C9IY94_HUMAN;tr|C9IZU3|C9IZU3_HUMAN;tr|C9JQJ4|C9JQJ4_HUMAN;tr|B5MD47|B5MD47_HUMAN;tr|C9JZI2|C9JZI2_HUMAN;tr|A0A0K0K1E7|A0A0K0K1E7_HUMAN;tr|C9JFT1|C9JFT1_HUMAN;tr|F8WB65|F8WB65_HUMAN;tr|H7C1T1|H7C1T1_HUMAN;tr|C9JT15|C9JT15_HUMAN;tr|C9JSE7|C9JSE7_HUMAN","sp|Q15019|SEPT2_HUMAN;tr|B5MCX3|B5MCX3_HUMAN;tr|C9J2Q4|C9J2Q4_HUMAN;tr|H7C2Y0|H7C2Y0_HUMAN",2537,"Q15019","SEPT2_HUMAN","Septin-2",null,"SEPT2"]
["24.9654","23.523","24.2909","24.3129","23.3296","24.3081",{"$nulls":3},"behavioral fear response;cellular response to dexamethasone stimulus;G1/S transition of mitotic cell cycle;lung development;mRNA export from nucleus;negative regulation of neuron differentiation;negative regulation of translation;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of mitotic cell cycle;regulation of translation;RNA export from nucleus;stem cell population maintenance;translational initiation;viral process","enzyme binding;eukaryotic initiation factor 4G binding;repressing transcription factor binding;RNA 7-methylguanosine cap binding;RNA binding;RNA cap binding;translation initiation factor activity","chromatoid body;cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;eukaryotic translation initiation factor 4F complex;extracellular exosome;mRNA cap binding complex;P-body;perinuclear region of cytoplasm;RISC complex","EGFR tyrosine kinase inhibitor resistance;HIF-1 signaling pathway;Insulin signaling pathway;Longevity regulating pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;RNA transport",null,null,7,7,3,"39.2","39.2","20.7","25.097",0,"57.058",2097800000,80,"0.20097",1,"0.276213","0.521518","sp|P06730|IF4E_HUMAN;tr|D6RBW1|D6RBW1_HUMAN;tr|D6RFJ3|D6RFJ3_HUMAN","sp|P06730|IF4E_HUMAN;tr|D6RBW1|D6RBW1_HUMAN",917,"P06730","IF4E_HUMAN","Eukaryotic translation initiation factor 4E","IF4E;IF-4E","EIF4E"]
["22.2317","19.9934","20.9685","21.3525","19.7497","21.2655",{"$nulls":3},"succinate metabolic process;succinyl-CoA metabolic process;succinyl-CoA pathway;tricarboxylic acid cycle","ATP binding;metal ion binding;succinate-CoA ligase (ADP-forming) activity","extracellular exosome;mitochondrial matrix;mitochondrion;myelin sheath","Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways;Propanoate metabolism",null,null,13,13,13,"30.9","30.9","30.9","50.317",0,"56.803",657210000,33,"0.120865",1,"0.275294","0.331271","sp|Q9P2R7|SUCB1_HUMAN;tr|Q5T9Q5|Q5T9Q5_HUMAN;tr|Q5T9Q8|Q5T9Q8_HUMAN","sp|Q9P2R7|SUCB1_HUMAN;tr|Q5T9Q5|Q5T9Q5_HUMAN",4940,"Q9P2R7","SUCB1_HUMAN","Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03220}",null,"SUCLA2"]
["23.0489","21.6991","23.1384","22.8459","21.5952","22.6207",{"$nulls":3},"3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;skeletal system development;sulfate assimilation","adenylylsulfate kinase activity;ATP binding;nucleotidyltransferase activity;protein homodimerization activity;sulfate adenylyltransferase (ATP) activity","cytosol","Metabolic pathways;Purine metabolism;Selenocompound metabolism;Sulfur metabolism",null,null,24,24,23,"47.4","47.4","45.2","70.832",0,"113.09",1933100000,102,"0.172179",1,"0.274857","0.455016","sp|O43252|PAPS1_HUMAN","sp|O43252|PAPS1_HUMAN",398,"O43252","PAPS1_HUMAN","Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1","APS synthase 1;APSS 1","PAPSS1"]
["19.736","17.6129","18.6502","19.5445","17.8851","17.7461",{"$nulls":3},"activation of protein kinase activity;apoptotic process;B cell proliferation;cell chemotaxis;cell cycle;cellular response to angiotensin;cellular response to hydrogen peroxide;cellular response to hydroperoxide;cellular senescence;defense response to bacterium;execution phase of apoptosis;Fc-gamma receptor signaling pathway involved in phagocytosis;histone phosphorylation;immunoglobulin mediated immune response;interferon-gamma-mediated signaling pathway;interleukin-10 production;interleukin-12 production;intrinsic apoptotic signaling pathway in response to oxidative stress;negative regulation of actin filament polymerization;negative regulation of filopodium assembly;negative regulation of glial cell apoptotic process;negative regulation of inflammatory response;negative regulation of insulin receptor signaling pathway;negative regulation of MAP kinase activity;negative regulation of peptidyl-tyrosine phosphorylation;negative regulation of platelet aggregation;negative regulation of protein binding;neutrophil activation;neutrophil degranulation;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;platelet activation;positive regulation of apoptotic signaling pathway;positive regulation of ceramide biosynthetic process;positive regulation of endodeoxyribonuclease activity;positive regulation of glucosylceramide catabolic process;positive regulation of phospholipid scramblase activity;positive regulation of protein dephosphorylation;positive regulation of protein import into nucleus;positive regulation of response to DNA damage stimulus;positive regulation of sphingomyelin catabolic process;positive regulation of superoxide anion generation;protein phosphorylation;protein stabilization;regulation of actin cytoskeleton organization;regulation of mRNA stability;regulation of receptor activity;signal transduction;stimulatory C-type lectin receptor signaling pathway;termination of signal transduction","ATP binding;calcium-independent protein kinase C activity;enzyme activator activity;enzyme binding;insulin receptor substrate binding;kinase binding;metal ion binding;non-membrane spanning protein tyrosine kinase activity;protein kinase activity;protein kinase binding;protein kinase C activity;protein serine/threonine kinase activity","azurophil granule lumen;cell-cell junction;cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;extracellular region;nuclear matrix;nucleoplasm;nucleus;perinuclear region of cytoplasm;plasma membrane","AGE-RAGE signaling pathway in diabetic complications;Autophagy - animal;Chemokine signaling pathway;C-type lectin receptor signaling pathway;Estrogen signaling pathway;Fc gamma R-mediated phagocytosis;GnRH signaling pathway;Inflammatory mediator regulation of TRP channels;Insulin resistance;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Type II diabetes mellitus;Vascular smooth muscle contraction",null,null,7,7,7,"12.9","12.9","12.9","77.504",0,"28.192",190150000,21,"0.118685",1,"0.27445","0.32584","sp|Q05655|KPCD_HUMAN;tr|C9J9P1|C9J9P1_HUMAN;tr|C9K0E3|C9K0E3_HUMAN","sp|Q05655|KPCD_HUMAN",2198,"Q05655","KPCD_HUMAN","Protein kinase C delta type",null,"PRKCD"]
["24.3163","23.5563","23.9237","24.1171","23.1873","23.6731",{"$nulls":3},"negative regulation of translation;positive regulation of dendrite morphogenesis;positive regulation of dendritic spine morphogenesis","RNA binding","cytoplasmic stress granule;cytosol;dendrite;integral component of plasma membrane;membrane;P-body",{"$nulls":3},17,17,17,"41.3","41.3","41.3","78.365",0,"249.88",3189900000,187,"0.323017",1,"0.272892","0.786954","sp|Q14444|CAPR1_HUMAN;tr|G3V153|G3V153_HUMAN;tr|A0A087X082|A0A087X082_HUMAN;tr|E9PLA9|E9PLA9_HUMAN","sp|Q14444|CAPR1_HUMAN;tr|G3V153|G3V153_HUMAN;tr|A0A087X082|A0A087X082_HUMAN;tr|E9PLA9|E9PLA9_HUMAN",2472,"Q14444","CAPR1_HUMAN","Caprin-1",null,"CAPRIN1"]
["23.6159","23.3283","23.9875","23.1798","23.3137","23.6219",{"$nulls":3},"defense response to bacterium;defense response to virus;ISG15-protein conjugation;negative regulation of protein ubiquitination;negative regulation of type I interferon production;negative regulation of viral genome replication;positive regulation of bone mineralization;regulation of interferon-gamma production;response to type I interferon;translesion synthesis;type I interferon signaling pathway;viral process",null,"cytosol;extracellular region;nucleoplasm","Epstein-Barr virus infection;Human papillomavirus infection;RIG-I-like receptor signaling pathway",null,null,9,9,9,"68.5","68.5","68.5","17.887",0,"149.01",1130300000,54,"0.516002",1,"0.272139","1.17605","sp|P05161|ISG15_HUMAN;tr|A0A096LPJ4|A0A096LPJ4_HUMAN;tr|A0A096LNZ9|A0A096LNZ9_HUMAN","sp|P05161|ISG15_HUMAN;tr|A0A096LPJ4|A0A096LPJ4_HUMAN;tr|A0A096LNZ9|A0A096LNZ9_HUMAN",896,"P05161","ISG15_HUMAN","Ubiquitin-like protein ISG15",null,"ISG15"]
["25.5484","24.5499","24.6218","25.2552","24.137","24.515",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of inflammatory response to antigenic stimulus;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","lipopolysaccharide binding;threonine-type endopeptidase activity","cytosol;extracellular exosome;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex","Proteasome",null,null,8,8,8,"48.5","48.5","48.5","29.204",0,"163.27",2880900000,90,"0.231267",1,"0.270987","0.589639","sp|P28070|PSB4_HUMAN","sp|P28070|PSB4_HUMAN",1334,"P28070","PSB4_HUMAN","Proteasome subunit beta type-4",null,"PSMB4"]
["23.9623","21.8392","21.898","23.2505","21.7381","21.9043",{"$nulls":5},"cytosol;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},8,8,8,"33.9","33.9","33.9","31.102",0,"64.609",973100000,37,"0.115385",1,"0.268866","0.317594","tr|A0A087WY55|A0A087WY55_HUMAN;sp|Q9NP79|VTA1_HUMAN;tr|Q5TGM0|Q5TGM0_HUMAN","tr|A0A087WY55|A0A087WY55_HUMAN;sp|Q9NP79|VTA1_HUMAN;tr|Q5TGM0|Q5TGM0_HUMAN",4625,"A0A087WY55","A0A087WY55_HUMAN",null,null,"VTA1"]
["27.5577","25.7892","26.6751","27.1389","25.4956","26.5835",{"$nulls":3},"cellular chloride ion homeostasis;cerebellum development;creatine metabolic process;substantia nigra development","ATP binding;creatine kinase activity;ubiquitin protein ligase binding","cytosol;dendrite;extracellular exosome;extracellular space;mitochondrion;myelin sheath;neuronal cell body;nucleus","Arginine and proline metabolism;Metabolic pathways",null,null,22,22,22,"77.4","77.4","77.4","42.644",0,"323.31",19059000000,449,"0.141326",1,"0.268023","0.381507","sp|P12277|KCRB_HUMAN;tr|G3V4N7|G3V4N7_HUMAN;tr|H0YJG0|H0YJG0_HUMAN;tr|G3V461|G3V461_HUMAN;tr|H0YJK0|H0YJK0_HUMAN;tr|G3V2I1|G3V2I1_HUMAN;sp|P06732|KCRM_HUMAN","sp|P12277|KCRB_HUMAN;tr|G3V4N7|G3V4N7_HUMAN",1065,"P12277","KCRB_HUMAN","Creatine kinase B-type {ECO:0000305}",null,"CKB"]
["23.4967","21.5511","22.5304","23.2971","21.2115","22.2666",{"$nulls":3},"lipid metabolic process;nucleus organization;phospholipid transport;retrograde vesicle-mediated transport, Golgi to ER","phosphatidylcholine binding;phosphatidylcholine transporter activity;phosphatidylinositol binding;phosphatidylinositol transporter activity","endoplasmic reticulum membrane;extracellular exosome;Golgi membrane",{"$nulls":3},15,15,13,"63.1","63.1","56.8","31.54",0,"75.971",1059800000,59,"0.11837",1,"0.267648","0.325057","sp|P48739|PIPNB_HUMAN;tr|A0A0A0MSW4|A0A0A0MSW4_HUMAN;tr|B3KYB6|B3KYB6_HUMAN;tr|B3KYB7|B3KYB7_HUMAN","sp|P48739|PIPNB_HUMAN;tr|A0A0A0MSW4|A0A0A0MSW4_HUMAN;tr|B3KYB6|B3KYB6_HUMAN;tr|B3KYB7|B3KYB7_HUMAN",1639,"P48739","PIPNB_HUMAN","Phosphatidylinositol transfer protein beta isoform","I-TP-beta;tdIns transfer protein beta;tdInsTP beta","PITPNB"]
["26.97","25.7048","25.8041","26.5068","25.4106","25.7589",{"$nulls":3},"cell differentiation involved in embryonic placenta development;cornification;keratinization;Notch signaling pathway;response to estrogen;sarcomere organization;viral process","protein complex binding;structural constituent of cytoskeleton;structural constituent of muscle","apicolateral plasma membrane;cell periphery;costamere;cytosol;dystrophin-associated glycoprotein complex;extracellular exosome;intermediate filament;plasma membrane;sarcolemma;terminal web;Z disc","Estrogen signaling pathway",null,null,34,31,1,"83.2","77.5","7.5","44.105",0,"323.31",23458000000,571,"0.198237",1,"0.267541","0.515283","sp|P08727|K1C19_HUMAN;tr|K7EMS3|K7EMS3_HUMAN;tr|C9JM50|C9JM50_HUMAN;sp|Q99456|K1C12_HUMAN;CON__Q99456;tr|K7ELP7|K7ELP7_HUMAN;sp|Q8N1A0|KT222_HUMAN;CON__Q8N1A0","sp|P08727|K1C19_HUMAN;tr|K7EMS3|K7EMS3_HUMAN",973,"P08727","K1C19_HUMAN","Keratin, type I cytoskeletal 19",null,"KRT19"]
["24.0889","23.5951","24.0437","23.5853","23.2647","24.0763",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"10.7","10.7","10.7","17.764",0,"7.9988",863880000,22,"0.39809",1,"0.26713","0.941268","tr|A6NNI4|A6NNI4_HUMAN;tr|G8JLH6|G8JLH6_HUMAN;sp|P21926|CD9_HUMAN;tr|F5GXT1|F5GXT1_HUMAN;tr|A0A087WZG3|A0A087WZG3_HUMAN;tr|A0A087WU13|A0A087WU13_HUMAN","tr|A6NNI4|A6NNI4_HUMAN;tr|G8JLH6|G8JLH6_HUMAN;sp|P21926|CD9_HUMAN",1234,"A6NNI4","A6NNI4_HUMAN","Tetraspanin {ECO:0000256|RuleBase:RU361218}",null,"CD9"]
["26.9787","25.1707","25.6756","26.5483","24.7303","25.7463",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal large subunit assembly;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;rRNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane","Ribosome",null,null,7,7,7,"54.5","54.5","54.5","17.818",0,"215.31",5962800000,137,"0.13014",1,"0.26667","0.354202","sp|P30050|RL12_HUMAN","sp|P30050|RL12_HUMAN",1372,"P30050","RL12_HUMAN","60S ribosomal protein L12",null,"RPL12"]
["16.4721","17.63","18.9117","17.7322","16.6938","17.7896",{"$nulls":3},"ER-dependent peroxisome organization;peroxisome membrane biogenesis;peroxisome organization;protein import into peroxisome matrix;protein import into peroxisome membrane;protein localization to endoplasmic reticulum;protein targeting to peroxisome;protein to membrane docking","protein C-terminus binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of peroxisomal membrane;membrane;peroxisomal membrane;peroxisome","Peroxisome",null,null,6,6,6,"22.9","22.9","22.9","38.628",0,"27.687",272050000,24,"0.123171",1,"0.266033","0.336997","sp|Q9Y5Y5|PEX16_HUMAN;tr|E9PMM3|E9PMM3_HUMAN;tr|E9PQW0|E9PQW0_HUMAN;tr|E9PLS4|E9PLS4_HUMAN;tr|E9PP98|E9PP98_HUMAN;tr|E9PMS3|E9PMS3_HUMAN","sp|Q9Y5Y5|PEX16_HUMAN;tr|E9PMM3|E9PMM3_HUMAN;tr|E9PQW0|E9PQW0_HUMAN;tr|E9PLS4|E9PLS4_HUMAN;tr|E9PP98|E9PP98_HUMAN",5376,"Q9Y5Y5","PEX16_HUMAN","Peroxisomal membrane protein PEX16",null,"PEX16"]
["22.0325","21.15","22.2008","21.8682","20.9703","21.7505",{"$nulls":3},"ubiquitin-dependent protein catabolic process","ubiquitin protein ligase binding","cullin-RING ubiquitin ligase complex;cytosol;nucleoplasm",{"$nulls":3},28,28,22,"40.1","40.1","33.3","102.75",0,"323.31",1910300000,125,"0.242624",1,"0.264798","0.61474","tr|K4DI93|K4DI93_HUMAN;sp|Q13620|CUL4B_HUMAN;tr|A6NE76|A6NE76_HUMAN","tr|K4DI93|K4DI93_HUMAN;sp|Q13620|CUL4B_HUMAN",2396,"K4DI93","K4DI93_HUMAN"]
["25.9478","24.1814","24.5882","25.366","23.9536","24.6044",{"$nulls":3},"translation","structural constituent of ribosome","small ribosomal subunit",{"$nulls":3},13,13,13,"62.7","62.7","62.7","29.404",0,"289.55",3713700000,109,"0.14627",1,"0.264463","0.393458","tr|C9J9K3|C9J9K3_HUMAN;sp|P08865|RSSA_HUMAN;tr|A0A0C4DG17|A0A0C4DG17_HUMAN;tr|A6NE09|A6NE09_HUMAN;tr|F8WD59|F8WD59_HUMAN;tr|C9JQR9|C9JQR9_HUMAN","tr|C9J9K3|C9J9K3_HUMAN;sp|P08865|RSSA_HUMAN;tr|A0A0C4DG17|A0A0C4DG17_HUMAN;tr|A6NE09|A6NE09_HUMAN;tr|F8WD59|F8WD59_HUMAN",976,"C9J9K3","C9J9K3_HUMAN",null,null,"RPSA"]
["25.0817","23.4271","24.4252","24.5984","23.2237","24.3211",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","identical protein binding;polyubiquitin modification-dependent protein binding;RNA binding","cytosol;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, base subcomplex","Epstein-Barr virus infection;Proteasome",null,null,11,11,2,"42.7","42.7","6.9","40.736",0,"231.57",2778500000,103,"0.154364",1,"0.263583","0.41288","sp|P55036|PSMD4_HUMAN;tr|H0Y3Y9|H0Y3Y9_HUMAN;tr|A6PVX3|A6PVX3_HUMAN;tr|H0Y561|H0Y561_HUMAN","sp|P55036|PSMD4_HUMAN",1832,"P55036","PSMD4_HUMAN","26S proteasome non-ATPase regulatory subunit 4",null,"PSMD4"]
["17.5799","16.8848","17.9383","17.2087","16.8286","17.5769",{"$nulls":3},"androgen receptor signaling pathway;intracellular steroid hormone receptor signaling pathway;positive regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","catalytic activity;receptor activity;thyroid hormone receptor binding;thyroid hormone receptor coactivator activity;transcription coactivator activity;transcription cofactor activity;vitamin D receptor binding","mediator complex;membrane;nucleoplasm;nucleus","Thyroid hormone signaling pathway",null,null,8,8,8,"11.6","11.6","11.6","96.792",0,"29.499",264740000,36,"0.280517",1,"0.262938","0.697007","sp|Q9Y2X0|MED16_HUMAN;tr|K7EKS6|K7EKS6_HUMAN;tr|U3KQ43|U3KQ43_HUMAN;tr|U3KQB4|U3KQB4_HUMAN;tr|B9TWZ6|B9TWZ6_HUMAN;tr|A0A0J9YYC6|A0A0J9YYC6_HUMAN;tr|A0A0J9YXE6|A0A0J9YXE6_HUMAN;tr|A0A0J9YXA0|A0A0J9YXA0_HUMAN;tr|B9TX03|B9TX03_HUMAN;tr|A0A0J9YXK9|A0A0J9YXK9_HUMAN;tr|A0A0J9YXL6|A0A0J9YXL6_HUMAN;tr|A0A0J9YW49|A0A0J9YW49_HUMAN;tr|A0A0J9YXE7|A0A0J9YXE7_HUMAN;tr|A0A0J9YY02|A0A0J9YY02_HUMAN;tr|B9TX12|B9TX12_HUMAN;tr|B9TX11|B9TX11_HUMAN","sp|Q9Y2X0|MED16_HUMAN;tr|K7EKS6|K7EKS6_HUMAN;tr|U3KQ43|U3KQ43_HUMAN;tr|U3KQB4|U3KQB4_HUMAN;tr|B9TWZ6|B9TWZ6_HUMAN;tr|A0A0J9YYC6|A0A0J9YYC6_HUMAN;tr|A0A0J9YXE6|A0A0J9YXE6_HUMAN;tr|A0A0J9YXA0|A0A0J9YXA0_HUMAN",5250,"Q9Y2X0","MED16_HUMAN","Mediator of RNA polymerase II transcription subunit 16",null,"MED16"]
["20.6091","19.405","19.8382","20.1273","19.2418","19.697",{"$nulls":3},"BMP signaling pathway;histone H2B conserved C-terminal lysine deubiquitination;monoubiquitinated protein deubiquitination;pathway-restricted SMAD protein phosphorylation;protein deubiquitination;transforming growth factor beta receptor signaling pathway;ubiquitin-dependent protein catabolic process","cysteine-type endopeptidase activity;identical protein binding;SMAD binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;transforming growth factor beta receptor binding;ubiquitin modification-dependent histone binding","cytoplasm;cytosol;mitochondrion;nucleus","Mitophagy - animal",null,null,22,21,21,30,"29.1","29.1","112.42",0,"71.124",486020000,66,"0.236942",1,"0.262051","0.60221","sp|Q9Y4E8|UBP15_HUMAN;tr|H0YI31|H0YI31_HUMAN;tr|F8W0H4|F8W0H4_HUMAN;tr|F8VVY7|F8VVY7_HUMAN;tr|F8VZG8|F8VZG8_HUMAN;tr|H0YHM4|H0YHM4_HUMAN;tr|H0YI26|H0YI26_HUMAN","sp|Q9Y4E8|UBP15_HUMAN",5324,"Q9Y4E8","UBP15_HUMAN","Ubiquitin carboxyl-terminal hydrolase 15",null,"USP15"]
["25.2834","24.0633","24.5778","24.8806","23.6996","24.5585",{"$nulls":3},"mitochondrion transport along microtubule;mRNA transport;negative regulation of mitochondrial RNA catabolic process;regulation of mitochondrial translation;regulation of transcription, DNA-templated;RNA modification;transcription, DNA-templated","beta-tubulin binding;endonuclease activity;microtubule binding;RNA binding;single-stranded DNA binding;ubiquitin protein ligase binding","condensed nuclear chromosome;cytoskeleton;intracellular ribonucleoprotein complex;membrane;microtubule;mitochondrial nucleoid;mitochondrion;nuclear inner membrane;nuclear outer membrane;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},77,77,76,"66.4","66.4","65.9","157.9",0,"323.31",24174000000,856,"0.20229",1,"0.261889","0.524524","sp|P42704|LPPRC_HUMAN;tr|A0A0C4DG06|A0A0C4DG06_HUMAN;tr|B8ZZ38|B8ZZ38_HUMAN;tr|C9JCA9|C9JCA9_HUMAN;tr|H7C3W8|H7C3W8_HUMAN","sp|P42704|LPPRC_HUMAN",1558,"P42704","LPPRC_HUMAN","Leucine-rich PPR motif-containing protein, mitochondrial",null,"LRPPRC"]
["23.0746","21.3636","22.7595","23.0655","21.3126","22.0394",{"$nulls":3},"aging;apoptotic mitochondrial changes;cellular response to fibroblast growth factor stimulus;cellular response to follicle-stimulating hormone stimulus;cellular response to glucose stimulus;cellular response to hepatocyte growth factor stimulus;cellular response to leukemia inhibitory factor;cellular response to thyroxine stimulus;cysteine metabolic process;glutamate metabolic process;glutathione biosynthetic process;hepatic stellate cell activation;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of neuron apoptotic process;positive regulation of glutamate-cysteine ligase activity;regulation of blood vessel size;regulation of mitochondrial depolarization;response to activity;response to drug;response to human chorionic gonadotropin;response to nitrosative stress;response to nutrient;response to oxidative stress","enzyme regulator activity;glutamate-cysteine ligase activity;glutamate-cysteine ligase catalytic subunit binding;protein heterodimerization activity","cytosol;glutamate-cysteine ligase complex","Cysteine and methionine metabolism;Ferroptosis;Glutathione metabolism;Metabolic pathways",null,null,9,9,9,"40.9","40.9","40.9","30.727",0,"38.188",496300000,38,"0.130704",1,"0.260079","0.355586","sp|P48507|GSH0_HUMAN","sp|P48507|GSH0_HUMAN",1630,"P48507","GSH0_HUMAN","Glutamate--cysteine ligase regulatory subunit",null,"GCLM"]
["21.5574","21.0413","21.53","21.3632","20.294","21.6936",{"$nulls":3},"protein insertion into membrane",null,"integral component of membrane;mitochondrion",{"$nulls":3},7,7,7,"16.3","16.3","16.3","48.519",0,"16.542",546580000,48,"0.222741",1,"0.259321","0.570646","tr|S4R3Q9|S4R3Q9_HUMAN;sp|Q15070|OXA1L_HUMAN;tr|J3KNA0|J3KNA0_HUMAN;tr|E7EVY0|E7EVY0_HUMAN;tr|C9JC63|C9JC63_HUMAN","tr|S4R3Q9|S4R3Q9_HUMAN;sp|Q15070|OXA1L_HUMAN;tr|J3KNA0|J3KNA0_HUMAN;tr|E7EVY0|E7EVY0_HUMAN",2556,"S4R3Q9","S4R3Q9_HUMAN",null,null,"OXA1L"]
["24.3814","23.8483","24.1489","24.3246","23.0646","24.2137",{"$nulls":3},"translational initiation","translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;extracellular exosome","RNA transport",null,null,16,16,16,"61.5","61.5","61.5","36.501",0,"176.27",2957100000,111,"0.235675",1,"0.258552","0.599408","sp|Q13347|EIF3I_HUMAN;tr|Q5TFK1|Q5TFK1_HUMAN","sp|Q13347|EIF3I_HUMAN",2340,"Q13347","EIF3I_HUMAN","Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008}","IF3i {ECO:0000255|HAMAP-Rule:MF_03008}","EIF3I"]
["25.8967","24.5783","24.7277","25.1219","24.5048","24.8051",{"$nulls":3},"apoptotic DNA fragmentation;astral microtubule organization;establishment of mitotic spindle localization;establishment of protein localization;intracellular transport of virus;mitotic chromosome movement towards spindle pole;mitotic metaphase plate congression;mitotic spindle assembly;modulation by virus of host process;neutrophil degranulation;NLS-bearing protein import into nucleus;protein import into nucleus;protein import into nucleus, translocation;Ran protein signal transduction;regulation of cholesterol biosynthetic process;ribosomal protein import into nucleus","enzyme binding;Hsp90 protein binding;nuclear localization sequence binding;protein domain specific binding;protein transporter activity;Ran GTPase binding;RNA binding;zinc ion binding","cytoplasm;cytosol;endoplasmic reticulum tubular network;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;host cell;membrane;nuclear envelope;nuclear membrane;nuclear periphery;nuclear pore;nucleoplasm;specific granule lumen","RNA transport",null,null,40,40,40,"54.8","54.8","54.8","97.169",0,"323.31",12409000000,363,"0.22106",1,"0.256951","0.566883","sp|Q14974|IMB1_HUMAN;tr|J3KTM9|J3KTM9_HUMAN;tr|J3QR48|J3QR48_HUMAN;tr|J3QKQ5|J3QKQ5_HUMAN;tr|J3QRG4|J3QRG4_HUMAN;tr|J3KS06|J3KS06_HUMAN","sp|Q14974|IMB1_HUMAN;tr|J3KTM9|J3KTM9_HUMAN",2518,"Q14974","IMB1_HUMAN","Importin subunit beta-1",null,"KPNB1"]
["23.3806","22.3926","22.3726","22.7818","22.2011","22.3969",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription initiation from RNA polymerase II promoter;positive regulation of viral transcription;RNA metabolic process;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","ATP binding;DNA binding;helicase activity;transcription factor activity, core RNA polymerase II binding","microtubule cytoskeleton;nucleoplasm;nucleus;transcription factor TFIIF complex;transcriptional preinitiation complex","Basal transcription factors",null,null,21,21,21,"78.3","78.3","78.3","28.38",0,"204.81",2601400000,126,"0.273959",1,"0.255328","0.682922","sp|P13984|T2FB_HUMAN","sp|P13984|T2FB_HUMAN",1094,"P13984","T2FB_HUMAN","General transcription factor IIF subunit 2",null,"GTF2F2"]
["28.8259","27.679","28.1336","28.3129","27.5054","28.0572",{"$nulls":3},"actin cytoskeleton organization;actin filament depolymerization;actin filament fragmentation;cytoskeleton organization;establishment of cell polarity;interleukin-12-mediated signaling pathway;mitotic cytokinesis;negative regulation of apoptotic process;neural crest cell migration;neural fold formation;positive regulation by host of viral process;positive regulation of actin filament depolymerization;protein phosphorylation;regulation of cell morphogenesis;regulation of dendritic spine morphogenesis;response to amino acid;response to virus;Rho protein signal transduction","actin filament binding;receptor binding","cell-cell junction;cortical actin cytoskeleton;cytoplasm;cytosol;extracellular exosome;extracellular matrix;extracellular space;focal adhesion;lamellipodium;lamellipodium membrane;membrane;nuclear matrix;nucleus;ruffle membrane;vesicle","Axon guidance;Fc gamma R-mediated phagocytosis;Human immunodeficiency virus 1 infection;Pertussis;Regulation of actin cytoskeleton",null,null,13,13,10,"68.7","68.7","51.8","18.502",0,"323.31",29260000000,317,"0.245293",1,"0.254351","0.620609","sp|P23528|COF1_HUMAN;tr|G3V1A4|G3V1A4_HUMAN;tr|E9PK25|E9PK25_HUMAN;tr|E9PP50|E9PP50_HUMAN;tr|E9PQB7|E9PQB7_HUMAN;tr|E9PLJ3|E9PLJ3_HUMAN;tr|E9PS23|E9PS23_HUMAN","sp|P23528|COF1_HUMAN;tr|G3V1A4|G3V1A4_HUMAN;tr|E9PK25|E9PK25_HUMAN;tr|E9PP50|E9PP50_HUMAN;tr|E9PQB7|E9PQB7_HUMAN;tr|E9PLJ3|E9PLJ3_HUMAN;tr|E9PS23|E9PS23_HUMAN",1270,"P23528","COF1_HUMAN","Cofilin-1",null,"CFL1"]
["23.3312","21.0061","20.9843","22.3273","21.1541","21.0807",{"$nulls":3},"galactose catabolic process","identical protein binding;protein homodimerization activity;UDP-glucose 4-epimerase activity;UDP-N-acetylglucosamine 4-epimerase activity","cytosol;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Metabolic pathways",null,null,11,11,11,"56.3","56.3","56.3","38.281",0,"200.49",724500000,70,"0.103915",1,"0.25318","0.288637","sp|Q14376|GALE_HUMAN;tr|Q5QPP3|Q5QPP3_HUMAN;tr|Q5QPP4|Q5QPP4_HUMAN;tr|Q5QPP1|Q5QPP1_HUMAN;tr|Q5QPP9|Q5QPP9_HUMAN","sp|Q14376|GALE_HUMAN;tr|Q5QPP3|Q5QPP3_HUMAN;tr|Q5QPP4|Q5QPP4_HUMAN",2470,"Q14376","GALE_HUMAN","UDP-glucose 4-epimerase {ECO:0000303|PubMed:22654673}",null,"GALE"]
["18.4605","16.308","16.7381","17.1178","16.4394","17.1917",{"$nulls":3},"angiogenesis;arterial endothelial cell fate commitment;atrioventricular canal development;auditory receptor cell fate commitment;B cell differentiation;blood vessel endothelial cell fate specification;blood vessel lumenization;blood vessel remodeling;cardiac left ventricle morphogenesis;Clara cell differentiation;defense response to bacterium;DNA recombination;dorsal aorta morphogenesis;endocardium morphogenesis;epidermal cell fate specification;epithelial to mesenchymal transition;epithelial to mesenchymal transition involved in endocardial cushion formation;hair follicle maturation;humoral immune response;inflammatory response to antigenic stimulus;interleukin-4 secretion;keratinocyte differentiation;labyrinthine layer blood vessel development;myeloid dendritic cell differentiation;negative regulation of cell differentiation;negative regulation of cell proliferation;negative regulation of ossification;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;Notch signaling involved in heart development;Notch signaling pathway;outflow tract morphogenesis;pituitary gland development;positive regulation of BMP signaling pathway;positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment;positive regulation of cardiac muscle cell proliferation;positive regulation of cell proliferation involved in heart morphogenesis;positive regulation of ephrin receptor signaling pathway;positive regulation of ERBB signaling pathway;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;positive regulation of transcription of Notch receptor target;regulation of timing of cell differentiation;regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;sebaceous gland development;secondary heart field specification;somatic stem cell population maintenance;somitogenesis;transcription initiation from RNA polymerase II promoter;ventricular trabecula myocardium morphogenesis","chromatin binding;DNA binding;DNA binding transcription factor activity;protein N-terminus binding;recombinase activity;repressing transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II repressing transcription factor binding;sequence-specific DNA binding;transcription factor binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytoplasm;MAML1-RBP-Jkappa- ICN1 complex;nucleolus;nucleoplasm;nucleus;transcription factor complex;transcriptional repressor complex","Epstein-Barr virus infection;Human papillomavirus infection;Notch signaling pathway;Th1 and Th2 cell differentiation;Viral carcinogenesis",null,null,3,3,3,"8.6","8.6","8.6","55.637",0,"6.2866",70594000,8,"0.132856",1,"0.25256","0.360864","sp|Q06330|SUH_HUMAN;tr|H0Y8R3|H0Y8R3_HUMAN;tr|D6R927|D6R927_HUMAN","sp|Q06330|SUH_HUMAN;tr|H0Y8R3|H0Y8R3_HUMAN;tr|D6R927|D6R927_HUMAN",2206,"Q06330","SUH_HUMAN","Recombining binding protein suppressor of hairless",null,"RBPJ"]
["19.4098","19.8166","19.1148","19.4856","19.3377","18.7624",{"$nulls":5},"cytoplasmic ribonucleoprotein granule;nuclear speck",{"$nulls":3},2,2,2,"11.7","11.7","11.7","23.661",0,"6.9149",70016000,11,"0.348169",1,"0.251832","0.839226","tr|X6R700|X6R700_HUMAN;sp|Q9Y3Y2|CHTOP_HUMAN;tr|A0A087X1B7|A0A087X1B7_HUMAN","tr|X6R700|X6R700_HUMAN;sp|Q9Y3Y2|CHTOP_HUMAN;tr|A0A087X1B7|A0A087X1B7_HUMAN",5309,"X6R700","X6R700_HUMAN",null,null,"CHTOP"]
["26.7867","25.0018","26.2522","26.4258","24.7647","26.0976",{"$nulls":3},"activation of innate immune response;brain development;cell proliferation;cellular hyperosmotic salinity response;cellular response to fatty acid;cellular response to gamma radiation;cellular response to leukemia inhibitory factor;cellular response to X-ray;DNA recombination;double-strand break repair;double-strand break repair via nonhomologous end joining;establishment of integrated proviral latency;hematopoietic stem cell differentiation;innate immune response;negative regulation of t-circle formation;negative regulation of transcription, DNA-templated;neutrophil degranulation;positive regulation of catalytic activity;positive regulation of neurogenesis;positive regulation of protein kinase activity;positive regulation of telomerase activity;positive regulation of telomere maintenance via telomerase;positive regulation of type I interferon production;protein localization to chromosome, telomeric region;regulation of smooth muscle cell proliferation;regulation of telomere maintenance;response to drug;telomere maintenance;transcription, DNA-templated","ATP binding;ATP-dependent DNA helicase activity;damaged DNA binding;DNA binding;double-stranded DNA binding;enzyme activator activity;macromolecular complex binding;protein C-terminus binding;RNA binding;telomeric DNA binding;transcription regulatory region DNA binding;ubiquitin protein ligase binding","cytosol;extracellular region;intracellular ribonucleoprotein complex;Ku70:Ku80 complex;membrane;nonhomologous end joining complex;nuclear chromosome, telomeric region;nuclear telomere cap complex;nucleolus;nucleoplasm;nucleus;plasma membrane;protein complex;protein-DNA complex;secretory granule lumen","Non-homologous end-joining",null,null,41,41,41,"68.4","68.4","68.4","82.704",0,"323.31",34486000000,874,"0.125255",1,"0.250893","0.342159","sp|P13010|XRCC5_HUMAN;tr|C9JZ81|C9JZ81_HUMAN;tr|H7C0H9|H7C0H9_HUMAN","sp|P13010|XRCC5_HUMAN",1074,"P13010","XRCC5_HUMAN","X-ray repair cross-complementing protein 5",null,"XRCC5"]
["23.7515","21.7372","22.3379","23.1994","21.5424","22.3337",{"$nulls":3},"[2Fe-2S] cluster assembly;cell redox homeostasis;negative regulation of cardiac muscle hypertrophy;protein maturation by iron-sulfur cluster transfer;regulation of the force of heart contraction","electron transfer activity;identical protein binding;iron-sulfur cluster binding;metal ion binding;protein disulfide oxidoreductase activity;protein kinase C binding;RNA binding","cell cortex;cytosol;dendrite;extracellular exosome;nucleus;Z disc",{"$nulls":3},10,10,10,"36.4","36.4","36.4","37.432",0,"60.45",1209400000,59,"0.119256",1,"0.250408","0.327265","sp|O76003|GLRX3_HUMAN","sp|O76003|GLRX3_HUMAN",660,"O76003","GLRX3_HUMAN","Glutaredoxin-3",null,"GLRX3"]
["27.7938","26.3311","27.0447","27.4024","25.8585","27.1585",{"$nulls":3},"angiogenesis;cellular response to epidermal growth factor stimulus;cellular response to leukemia inhibitory factor;negative regulation of translation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter","DNA topoisomerase binding;identical protein binding;mRNA 5'-UTR binding;protein C-terminus binding;RNA binding;telomeric DNA binding","cell cortex;cytoplasmic ribonucleoprotein granule;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus","Pathogenic Escherichia coli infection",null,null,24,24,24,"32.4","32.4","32.4","76.613",0,"323.31",49043000000,452,"0.14546",1,"0.250056","0.391504","sp|P19338|NUCL_HUMAN;tr|H7BY16|H7BY16_HUMAN","sp|P19338|NUCL_HUMAN;tr|H7BY16|H7BY16_HUMAN",1189,"P19338","NUCL_HUMAN","Nucleolin",null,"NCL"]
["16.317","16.5251","15.9889","15.7909","15.927","16.3666",{"$nulls":3},"regulation of transcription from RNA polymerase II promoter","DNA binding","nucleus",{"$nulls":3},1,1,1,"2.5","2.5","2.5","63.112","0.0013545","3.1332",31326000,4,"0.460097",1,"0.248822","1.06558","tr|F8W689|F8W689_HUMAN;sp|P48382|RFX5_HUMAN","tr|F8W689|F8W689_HUMAN;sp|P48382|RFX5_HUMAN",1624,"F8W689","F8W689_HUMAN",null,null,"RFX5"]
["22.9152","22.7821","23.3813","22.531","22.7499","23.0563",{"$nulls":3},"hippo signaling","metal ion binding","cytosol;extracellular exosome;nucleolus;nucleus","Hippo signaling pathway;Hippo signaling pathway - multiple species",null,null,5,5,5,"25.5","25.5","25.5","25.079",0,"34.66",730550000,36,"0.448456",1,"0.247133","1.04241","sp|Q9H8S9|MOB1A_HUMAN;sp|Q7L9L4|MOB1B_HUMAN;tr|D6RCK3|D6RCK3_HUMAN","sp|Q9H8S9|MOB1A_HUMAN;sp|Q7L9L4|MOB1B_HUMAN;tr|D6RCK3|D6RCK3_HUMAN",4522,"Q9H8S9","MOB1A_HUMAN","MOB kinase activator 1A",null,"MOB1A"]
["27.4588","25.9782","26.7857","27.0996","25.6459","26.7367",{"$nulls":3},"ATP metabolic process;cellular heat acclimation;cellular response to heat;cellular response to oxidative stress;mRNA catabolic process;negative regulation of apoptotic process;negative regulation of cell death;negative regulation of cell growth;negative regulation of cell proliferation;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;negative regulation of inclusion body assembly;negative regulation of protein ubiquitination;neutrophil degranulation;positive regulation of gene expression;positive regulation of interleukin-8 production;positive regulation of microtubule nucleation;positive regulation of NF-kappaB transcription factor activity;positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;positive regulation of tumor necrosis factor-mediated signaling pathway;protein refolding;protein stabilization;regulation of cellular response to heat;regulation of mitotic spindle assembly;regulation of protein ubiquitination","ATP binding;ATPase activity;ATPase activity, coupled;C3HC4-type RING finger domain binding;enzyme binding;G-protein coupled receptor binding;heat shock protein binding;histone deacetylase binding;protein binding involved in protein folding;protein N-terminus binding;receptor binding;RNA binding;ubiquitin protein ligase binding;unfolded protein binding;virus receptor activity","aggresome;blood microparticle;centriole;centrosome;cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;inclusion body;intracellular ribonucleoprotein complex;mitochondrion;nuclear speck;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex;vesicle","Antigen processing and presentation;Endocytosis;Estrogen signaling pathway;Legionellosis;Longevity regulating pathway - multiple species;MAPK signaling pathway;Measles;Prion diseases;Protein processing in endoplasmic reticulum;Spliceosome;Toxoplasmosis",null,null,34,32,21,"67.1",64,"44.1","70.051",0,"323.31",33685000000,570,"0.150486",1,"0.246824","0.403595","sp|P0DMV9|HS71B_HUMAN;sp|P0DMV8|HS71A_HUMAN;tr|A0A0G2JIW1|A0A0G2JIW1_HUMAN;tr|V9GZ37|V9GZ37_HUMAN","sp|P0DMV9|HS71B_HUMAN;sp|P0DMV8|HS71A_HUMAN;tr|A0A0G2JIW1|A0A0G2JIW1_HUMAN;tr|V9GZ37|V9GZ37_HUMAN",1012,"P0DMV9","HS71B_HUMAN","Heat shock 70 kDa protein 1B {ECO:0000312|HGNC:HGNC:5233}",null,"HSPA1B"]
["23.2068","21.9885","22.1565","22.7307","22.056","21.8296",{"$nulls":3},"xenobiotic metabolic process","hydrolase activity","cytosol;extracellular exosome","Metabolic pathways",null,null,10,10,10,"46.1","46.1","46.1","28.048",0,"76.781",930160000,60,"0.202234",1,"0.245152","0.524397","sp|Q96DG6|CMBL_HUMAN","sp|Q96DG6|CMBL_HUMAN",3840,"Q96DG6","CMBL_HUMAN","Carboxymethylenebutenolidase homolog",null,"CMBL"]
["23.3056","21.9158","22.4205","22.6224","21.9961","22.2924",{"$nulls":3},"cellular response to amino acid starvation;cellular response to amino acid stimulus;cellular response to leucine;cellular response to leucine starvation;glutaminyl-tRNA aminoacylation;leucyl-tRNA aminoacylation;negative regulation of autophagy;positive regulation of GTPase activity;positive regulation of TORC1 signaling;protein targeting to lysosome;regulation of cell size;tRNA aminoacylation for protein translation;valyl-tRNA aminoacylation","aminoacyl-tRNA editing activity;ATP binding;glutamine-tRNA ligase activity;GTPase activator activity;leucine-tRNA ligase activity;valine-tRNA ligase activity","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;endomembrane system;endoplasmic reticulum;lysosome;nuclear body","Aminoacyl-tRNA biosynthesis",null,null,49,49,49,"49.4","49.4","49.4","134.46",0,"323.31",7337500000,439,"0.212625",1,"0.243637","0.547933","sp|Q9P2J5|SYLC_HUMAN;tr|A0A087WXY1|A0A087WXY1_HUMAN","sp|Q9P2J5|SYLC_HUMAN",4935,"Q9P2J5","SYLC_HUMAN","Leucine--tRNA ligase, cytoplasmic",null,"LARS"]
["18.6417","16.5534","17.0639","18.3188","16.0004","17.2107",{"$nulls":4},"purine nucleotide binding",{"$nulls":4},4,4,4,"10.7","10.7","10.7","55.468",0,"12.052",63806000,11,"0.0945673",1,"0.243062","0.264691","sp|Q9NRY5|F1142_HUMAN;tr|E7ESJ7|E7ESJ7_HUMAN;tr|E5RK42|E5RK42_HUMAN;tr|E5RHP2|E5RHP2_HUMAN;tr|E5RHI8|E5RHI8_HUMAN;tr|E5RFK2|E5RFK2_HUMAN;tr|E5RGF9|E5RGF9_HUMAN;tr|I6L9D5|I6L9D5_HUMAN","sp|Q9NRY5|F1142_HUMAN;tr|E7ESJ7|E7ESJ7_HUMAN",4706,"Q9NRY5","F1142_HUMAN","Protein FAM114A2",null,"FAM114A2"]
["22.8062","21.2314","22.4537","22.5657","21.3929","21.8048",{"$nulls":4},"SH3 domain binding;SH3/SH2 adaptor activity","cytoplasm;extracellular exosome;extracellular space;nucleus",{"$nulls":3},5,5,5,"69.3","69.3","69.3","12.774",0,"21.689",349320000,23,"0.154265",1,"0.242612","0.412642","sp|O75368|SH3L1_HUMAN","sp|O75368|SH3L1_HUMAN",574,"O75368","SH3L1_HUMAN","SH3 domain-binding glutamic acid-rich-like protein",null,"SH3BGRL"]
["21.3829","20.3821","20.9617","21.1893","19.7512","21.0599",{"$nulls":3},"apoptotic process;camera-type eye development;cell fate specification;chaperone-mediated protein folding;dorsal/ventral neural tube patterning;intracellular signal transduction;multicellular organism growth;negative regulation of apoptotic process;negative regulation of protein phosphorylation;positive regulation of BMP signaling pathway;smoothened signaling pathway;viral process","disordered domain specific binding;FK506 binding;identical protein binding;metal ion binding;peptidyl-prolyl cis-trans isomerase activity","cytoplasm;cytosol;endoplasmic reticulum;integral component of endoplasmic reticulum membrane;membrane;mitochondrial membrane;mitochondrion;protein complex",{"$nulls":3},6,6,6,"24.5","24.5","24.5","44.561",0,"68.406",421640000,45,"0.168154",1,"0.242064","0.445566","sp|Q14318|FKBP8_HUMAN;tr|M0R2K9|M0R2K9_HUMAN;tr|M0R1Q0|M0R1Q0_HUMAN;tr|M0R1S6|M0R1S6_HUMAN;tr|U3KQ64|U3KQ64_HUMAN;tr|M0R2Q6|M0R2Q6_HUMAN;tr|A0A0A0MTJ1|A0A0A0MTJ1_HUMAN;tr|U3KQI1|U3KQI1_HUMAN","sp|Q14318|FKBP8_HUMAN;tr|M0R2K9|M0R2K9_HUMAN",2465,"Q14318","FKBP8_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP8","PIase FKBP8","FKBP8"]
["24.6115","22.3657","25.0134","24.0485","22.4527","24.7684",{"$nulls":3},"antigen processing and presentation;axonogenesis;cellular response to insulin stimulus;endoplasmic reticulum tubular network organization;endosomal transport;establishment of neuroblast polarity;establishment of protein localization to endoplasmic reticulum membrane;establishment of protein localization to membrane;Golgi to plasma membrane protein transport;Golgi to plasma membrane transport;neutrophil degranulation;polarized epithelial cell differentiation;protein localization to basolateral plasma membrane;protein localization to plasma membrane;protein secretion;regulation of exocytosis;vesicle docking involved in exocytosis;vesicle-mediated transport","cadherin binding involved in cell-cell adhesion;GDP binding;GTP binding;GTPase activity;myosin V binding","cell-cell adherens junction;cilium;cytoplasmic vesicle membrane;cytosol;endoplasmic reticulum membrane;endoplasmic reticulum tubular network;endosome;exocytic vesicle;extracellular exosome;focal adhesion;Golgi apparatus;Golgi membrane;insulin-responsive compartment;phagocytic vesicle membrane;plasma membrane;recycling endosome;recycling endosome membrane;secretory granule membrane;trans-Golgi network","AMPK signaling pathway;Endocytosis",null,null,10,9,8,46,"40.5",37,"22.541",0,"167.42",2321600000,70,"0.0791303",1,"0.240323","0.224416","sp|P61026|RAB10_HUMAN","sp|P61026|RAB10_HUMAN",1913,"P61026","RAB10_HUMAN","Ras-related protein Rab-10",null,"RAB10"]
["22.7469","21.7374","22.3463","22.9206","21.2772","21.9166",{"$nulls":3},"angiotensin-activated signaling pathway;bicarbonate transport;carbon dioxide transport;cellular response to fluid shear stress;kidney development;morphogenesis of an epithelium;odontogenesis of dentin-containing tooth;one-carbon metabolic process;positive regulation of bone resorption;positive regulation of cellular pH reduction;positive regulation of dipeptide transmembrane transport;positive regulation of osteoclast differentiation;positive regulation of synaptic transmission, GABAergic;regulation of anion transport;regulation of chloride transport;regulation of intracellular pH;response to estrogen;response to pH;response to steroid hormone;response to zinc ion;secretion","arylesterase activity;carbonate dehydratase activity;zinc ion binding","apical part of cell;axon;basolateral plasma membrane;cytoplasm;cytosol;extracellular exosome;microvillus;myelin sheath;plasma membrane","Bile secretion;Collecting duct acid secretion;Gastric acid secretion;Metabolic pathways;Nitrogen metabolism;Pancreatic secretion;Proximal tubule bicarbonate reclamation",null,null,8,8,8,"43.5","43.5","43.5","29.246",0,"62.621",641490000,41,"0.159638",1,"0.238721","0.425438","sp|P00918|CAH2_HUMAN;tr|E5RID5|E5RID5_HUMAN;tr|E5RK37|E5RK37_HUMAN","sp|P00918|CAH2_HUMAN",837,"P00918","CAH2_HUMAN","Carbonic anhydrase 2",null,"CA2"]
["21.5993","20.0994","21.1655","21.3688","19.9833","20.7965",{"$nulls":3},"histone H2B ubiquitination;histone monoubiquitination;negative regulation of mRNA polyadenylation;positive regulation of histone H2B ubiquitination;positive regulation of proteasomal protein catabolic process;positive regulation of protein polyubiquitination;protein ubiquitination;response to peptide hormone;ubiquitin-dependent protein catabolic process","metal ion binding;mRNA 3'-UTR binding;protein complex binding;protein homodimerization activity;syntaxin-1 binding;ubiquitin conjugating enzyme binding;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","axon terminus;cytosol;extrinsic component of membrane;HULC complex;membrane;neuron projection;nucleoplasm;nucleus;ubiquitin ligase complex",{"$nulls":3},24,22,22,"29.9","28.3","28.3","113.65",0,"105.6",962320000,63,"0.147936",1,"0.238534","0.397471","sp|O75150|BRE1B_HUMAN;tr|H3BP71|H3BP71_HUMAN;tr|H3BS50|H3BS50_HUMAN;tr|A0A087WTK2|A0A087WTK2_HUMAN;tr|H3BQ99|H3BQ99_HUMAN;tr|H3BUL6|H3BUL6_HUMAN;tr|I3L332|I3L332_HUMAN","sp|O75150|BRE1B_HUMAN;tr|H3BP71|H3BP71_HUMAN",549,"O75150","BRE1B_HUMAN","E3 ubiquitin-protein ligase BRE1B","RE1-B","RNF40"]
["20.976","22.0841","22.9163","22.3458","21.328","21.5893",{"$nulls":3},"behavioral response to nutrient;cellular response to organic cyclic compound;centrosome cycle;glucose homeostasis;leukocyte migration;lipid metabolic process;mevalonate transport;monocarboxylic acid transport;plasma membrane lactate transport;pyruvate metabolic process;regulation of insulin secretion;response to food","lactate transmembrane transporter activity;mevalonate transmembrane transporter activity;monocarboxylic acid transmembrane transporter activity;organic cyclic compound binding;protein homodimerization activity;symporter activity","cell junction;centrosome;extracellular exosome;integral component of membrane;integral component of plasma membrane;intracellular membrane-bounded organelle;membrane;mitochondrion;plasma membrane",{"$nulls":3},7,7,7,"10.2","10.2","10.2","53.944",0,"31.445",1268700000,48,"0.137336",1,"0.237786","0.371809","sp|P53985|MOT1_HUMAN;tr|Q5T8R5|Q5T8R5_HUMAN;tr|Q5T8R3|Q5T8R3_HUMAN;tr|Q5T8R4|Q5T8R4_HUMAN","sp|P53985|MOT1_HUMAN;tr|Q5T8R5|Q5T8R5_HUMAN",1809,"P53985","MOT1_HUMAN","Monocarboxylate transporter 1","CT 1","SLC16A1"]
["18.4229","17.0437","18.3562","18.4118","17.1563","17.5429",{"$nulls":3},"base-excision repair, DNA ligation;cell cycle;cell division;DNA biosynthetic process;DNA ligation;DNA replication;double-strand break repair;double-strand break repair via alternative nonhomologous end joining;double-strand break repair via homologous recombination;mitochondrial DNA repair;mitochondrion organization;negative regulation of mitochondrial DNA replication;nucleotide-excision repair, DNA gap filling;transcription-coupled nucleotide-excision repair","ATP binding;DNA binding;DNA ligase (ATP) activity;DNA ligase activity;zinc ion binding","DNA ligase III-XRCC1 complex;mitochondrion;nucleoplasm;nucleus","Base excision repair",null,null,25,25,25,"31.1","31.1","31.1","112.91",0,"72.038",543510000,68,"0.151982",1,"0.237238","0.407183","sp|P49916|DNLI3_HUMAN;tr|K7ERZ5|K7ERZ5_HUMAN;tr|K7EQB6|K7EQB6_HUMAN;tr|K7ENR9|K7ENR9_HUMAN;tr|K7EJR4|K7EJR4_HUMAN;tr|K7ELY6|K7ELY6_HUMAN","sp|P49916|DNLI3_HUMAN;tr|K7ERZ5|K7ERZ5_HUMAN",1696,"P49916","DNLI3_HUMAN","DNA ligase 3",null,"LIG3"]
["27.3196","25.755","26.7533","26.9755","25.535","26.6129",{"$nulls":3},"chloride transport;platelet aggregation;positive regulation of osteoblast differentiation;regulation of cell cycle;regulation of ion transmembrane transport;regulation of mitochondrial membrane potential;signal transduction","cadherin binding;chloride channel activity;voltage-gated ion channel activity","blood microparticle;brush border;chloride channel complex;cytoplasm;extracellular exosome;extracellular space;membrane;mitochondrion;nuclear envelope;nuclear membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;vesicle",{"$nulls":3},15,15,15,"75.1","75.1","75.1","26.922",0,"323.31",14210000000,207,"0.137827",1,"0.234821","0.373005","sp|O00299|CLIC1_HUMAN","sp|O00299|CLIC1_HUMAN",224,"O00299","CLIC1_HUMAN","Chloride intracellular channel protein 1",null,"CLIC1"]
["19.2392",1,"16.2528","18.1566",1,"16.6311",{"$nulls":9},6,6,6,"16.8","16.8","16.8","73.338",0,"15.084",70544000,6,"0.00982347",1,"0.234772","0.0298262","tr|A0A087X0Q9|A0A087X0Q9_HUMAN;sp|Q9BVL4|SELO_HUMAN","tr|A0A087X0Q9|A0A087X0Q9_HUMAN;sp|Q9BVL4|SELO_HUMAN",4257,"A0A087X0Q9","A0A087X0Q9_HUMAN",null,null,"SELENOO"]
["24.2136","22.8924","23.6079","23.9806","22.3025","23.73",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity",{"$nulls":4},16,16,16,"50.9","50.9","50.9","45.31",0,"323.31",12911000000,458,"0.13289",1,"0.233634","0.360948","tr|E7EU96|E7EU96_HUMAN;sp|P68400|CSK21_HUMAN;tr|Q5U5J2|Q5U5J2_HUMAN;sp|Q8NEV1|CSK23_HUMAN;tr|A0A087WY74|A0A087WY74_HUMAN;tr|V9GYA2|V9GYA2_HUMAN;tr|V9GY80|V9GY80_HUMAN","tr|E7EU96|E7EU96_HUMAN;sp|P68400|CSK21_HUMAN;tr|Q5U5J2|Q5U5J2_HUMAN;sp|Q8NEV1|CSK23_HUMAN",2047,"E7EU96","E7EU96_HUMAN",null,null,"CSNK2A1"]
["24.444","23.696","23.9815","24.2967","23.2346","23.8928",{"$nulls":3},"cell cycle;cell division;positive regulation of non-motile cilium assembly;protein heterooligomerization","cadherin binding;GTP binding;GTPase activity","actin cytoskeleton;axoneme;cytoplasm;microtubule;non-motile cilium;perinuclear region of cytoplasm;septin complex;stress fiber","Bacterial invasion of epithelial cells",null,null,33,33,33,"57.7","57.7","57.7","65.401",0,"323.31",7523600000,282,"0.242356",1,"0.232473","0.614151","sp|Q9UHD8|SEPT9_HUMAN;tr|K7EL40|K7EL40_HUMAN;tr|K7EK18|K7EK18_HUMAN;tr|K7ER52|K7ER52_HUMAN;tr|K7ENL0|K7ENL0_HUMAN;tr|K7EIE4|K7EIE4_HUMAN;tr|K7EQD7|K7EQD7_HUMAN;tr|K7ER14|K7ER14_HUMAN;tr|K7EJV0|K7EJV0_HUMAN;tr|K7EJ51|K7EJ51_HUMAN;tr|K7ELJ9|K7ELJ9_HUMAN;tr|K7EPY1|K7EPY1_HUMAN;tr|K7EJZ2|K7EJZ2_HUMAN;tr|K7EJL9|K7EJL9_HUMAN;tr|K7EIR4|K7EIR4_HUMAN;tr|K7EKN4|K7EKN4_HUMAN;tr|K7EN52|K7EN52_HUMAN;tr|K7ENQ5|K7ENQ5_HUMAN;tr|K7ERG1|K7ERG1_HUMAN;tr|K7EQ08|K7EQ08_HUMAN;tr|K7ER34|K7ER34_HUMAN","sp|Q9UHD8|SEPT9_HUMAN",5021,"Q9UHD8","SEPT9_HUMAN","Septin-9",null,"SEPT9"]
["26.9206","25.7808","26.7321","26.5831","25.6741","26.4831",{"$nulls":3},"CRD-mediated mRNA stabilization;in utero embryonic development;mRNA splicing, via spliceosome;negative regulation of striated muscle cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell division;positive regulation of transcription from RNA polymerase II promoter;protein localization to cytoplasmic stress granule;regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter","chromatin binding;DNA binding;DNA binding transcription factor activity;double-stranded DNA binding;GTPase binding;RNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;single-stranded DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","CRD-mediated mRNA stability complex;cytoplasm;cytoplasmic stress granule;cytosol;extracellular exosome;histone pre-mRNA 3'end processing complex;intracellular membrane-bounded organelle;intracellular ribonucleoprotein complex;nuclear membrane;nucleoplasm;nucleus;U12-type spliceosomal complex",{"$nulls":3},18,18,14,"65.1","65.1","53.7","35.924",0,"323.31",11033000000,262,"0.194869",1,"0.231066","0.50758","sp|P67809|YBOX1_HUMAN;tr|A0A087X1S2|A0A087X1S2_HUMAN;tr|H0Y449|H0Y449_HUMAN;tr|C9J5V9|C9J5V9_HUMAN;sp|Q9Y2T7|YBOX2_HUMAN","sp|P67809|YBOX1_HUMAN;tr|A0A087X1S2|A0A087X1S2_HUMAN;tr|H0Y449|H0Y449_HUMAN;tr|C9J5V9|C9J5V9_HUMAN",2037,"P67809","YBOX1_HUMAN","Nuclease-sensitive element-binding protein 1",null,"YBX1"]
["19.0857","18.1394",1,"18.0311","18.501",1,{"$nulls":5},"cytosol;nucleus",{"$nulls":3},4,4,4,"16.1","16.1","16.1","37.455",0,"5.8009",43387000,7,"0.00924106",1,"0.230982","0.028076","tr|B3KRD8|B3KRD8_HUMAN;sp|O76054|S14L2_HUMAN;tr|H7C417|H7C417_HUMAN;tr|C9JZI9|C9JZI9_HUMAN;tr|H7C4C6|H7C4C6_HUMAN;tr|H7C1K3|H7C1K3_HUMAN","tr|B3KRD8|B3KRD8_HUMAN;sp|O76054|S14L2_HUMAN;tr|H7C417|H7C417_HUMAN;tr|C9JZI9|C9JZI9_HUMAN",664,"B3KRD8","B3KRD8_HUMAN"]
["23.0512","20.8321","22.0035","22.6661","20.3818","22.1487",{"$nulls":3},"carnitine metabolic process;cellular organofluorine metabolic process;cellular response to follicle-stimulating hormone stimulus;cellular response to peptide hormone stimulus;demethylation;fatty acid oxidation;flavonoid metabolic process;internal peptidyl-lysine acetylation;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of lipase activity;nitrate catabolic process;nitric oxide catabolic process;oxidation-reduction process;positive regulation of cholesterol biosynthetic process;positive regulation of chondrocyte differentiation;positive regulation of monooxygenase activity;positive regulation of smoothened signaling pathway;positive regulation of steroid hormone biosynthetic process;regulation of growth plate cartilage chondrocyte proliferation;response to drug;response to nutrient;xenobiotic metabolic process","cytochrome-b5 reductase activity, acting on NAD(P)H;electron transfer activity;enzyme binding;flavin adenine dinucleotide binding;FMN binding;hydrolase activity;iron-cytochrome-c reductase activity;NADP binding;NADPH-hemoprotein reductase activity;nitric oxide dioxygenase activity","endoplasmic reticulum membrane;integral component of membrane;intracellular membrane-bounded organelle;membrane;mitochondrion",{"$nulls":3},25,25,25,"45.9","45.9","45.9","76.689",0,"275.81",1639400000,90,"0.086605",1,"0.23009","0.244035","sp|P16435|NCPR_HUMAN;tr|H0Y4R2|H0Y4R2_HUMAN;tr|E7EMD0|E7EMD0_HUMAN;tr|E7EWU0|E7EWU0_HUMAN;tr|C9JU80|C9JU80_HUMAN","sp|P16435|NCPR_HUMAN;tr|H0Y4R2|H0Y4R2_HUMAN;tr|E7EMD0|E7EMD0_HUMAN",1137,"P16435","NCPR_HUMAN","NADPH--cytochrome P450 reductase {ECO:0000255|HAMAP-Rule:MF_03212}","450R {ECO:0000255|HAMAP-Rule:MF_03212};PR {ECO:0000255|HAMAP-Rule:MF_03212}","POR"]
["27.2927","26.726","27.2752","27.317","26.1915","27.0975",{"$nulls":3},"DNA replication;negative regulation of histone acetylation;negative regulation of neuron apoptotic process;negative regulation of transcription, DNA-templated;nucleocytoplasmic transport;nucleosome assembly;nucleosome disassembly;regulation of mRNA stability;viral process","DNA binding;histone binding;protein phosphatase inhibitor activity;protein phosphatase regulator activity","cytoplasm;cytosol;endoplasmic reticulum;lipid droplet;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex",{"$nulls":3},10,10,10,"45.2","45.2","45.2","33.488",0,"323.31",10499000000,140,"0.229492",1,"0.2293","0.585696","sp|Q01105|SET_HUMAN;tr|A0A0C4DFV9|A0A0C4DFV9_HUMAN;tr|A0A087X027|A0A087X027_HUMAN;sp|P0DME0|SETLP_HUMAN","sp|Q01105|SET_HUMAN;tr|A0A0C4DFV9|A0A0C4DFV9_HUMAN;tr|A0A087X027|A0A087X027_HUMAN;sp|P0DME0|SETLP_HUMAN",2130,"Q01105","SET_HUMAN","Protein SET",null,"SET"]
["21.6358","21.6076","21.0198","20.8017","21.22","21.5568",{"$nulls":3},"anterior/posterior pattern specification;camera-type eye morphogenesis;cell differentiation;cellular response to DNA damage stimulus;cellular response to interleukin-1;cellular response to UV;chromosome organization;double-strand break repair via homologous recombination;negative regulation of gene expression;negative regulation of interferon-beta production;negative regulation of pri-miRNA transcription from RNA polymerase II promoter;negative regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein deubiquitination;regulation of transcription from RNA polymerase II promoter;response to prostaglandin F;response to UV-C;RNA localization;spermatogenesis;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;enhancer sequence-specific DNA binding;four-way junction DNA binding;histone deacetylase binding;proximal promoter sequence-specific DNA binding;RNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;SMAD binding;transcription coactivator activity;transcription corepressor activity;transcription regulatory region DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;zinc ion binding","cytoplasm;Ino80 complex;nuclear matrix;nucleoplasm;nucleus;PcG protein complex;transcription factor complex",{"$nulls":3},7,7,4,"21.7","21.7","15.2","44.712",0,"79.024",1042700000,54,"0.314587",1,"0.228228","0.769284","sp|P25490|TYY1_HUMAN;tr|H0YJV7|H0YJV7_HUMAN;tr|H0YJU4|H0YJU4_HUMAN;sp|Q96MM3|ZFP42_HUMAN","sp|P25490|TYY1_HUMAN;tr|H0YJV7|H0YJV7_HUMAN",1291,"P25490","TYY1_HUMAN","Transcriptional repressor protein YY1",null,"YY1"]
["23.098","21.7472","22.5951","22.6758","21.5544","22.5268",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome regulatory particle assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway",null,"cytosol;nucleoplasm;proteasome accessory complex;proteasome complex",{"$nulls":3},20,20,20,"54.4","54.4","54.4","56.195",0,"312.15",1477900000,95,"0.162084",1,"0.227772","0.431238","sp|Q16401|PSMD5_HUMAN;tr|F2Z3J2|F2Z3J2_HUMAN;tr|Q4VXH0|Q4VXH0_HUMAN","sp|Q16401|PSMD5_HUMAN",2662,"Q16401","PSMD5_HUMAN","26S proteasome non-ATPase regulatory subunit 5",null,"PSMD5"]
["26.7788","25.7774","25.7659","26.3759","25.4732","25.7922",{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;RNA metabolic process;viral RNA genome replication","cadherin binding;mRNA binding;RNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific single stranded DNA binding;single-stranded DNA binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;extracellular exosome;membrane;nuclear speck;nucleoplasm","Ferroptosis;Spliceosome",null,null,19,19,14,"85.7","85.7","73.9","37.497",0,"323.31",10759000000,245,"0.205134",1,"0.22689","0.530988","sp|Q15365|PCBP1_HUMAN;tr|F8VTZ0|F8VTZ0_HUMAN;tr|H3BSP4|H3BSP4_HUMAN;tr|C9K0A2|C9K0A2_HUMAN;tr|F8WC71|F8WC71_HUMAN;tr|C9IZV9|C9IZV9_HUMAN;tr|C9J7A9|C9J7A9_HUMAN;tr|C9JSA6|C9JSA6_HUMAN;tr|C9J5V4|C9J5V4_HUMAN;tr|C9JTY5|C9JTY5_HUMAN;tr|C9JZY3|C9JZY3_HUMAN;tr|C9J0A4|C9J0A4_HUMAN;tr|F6TJN8|F6TJN8_HUMAN;sp|P57723|PCBP4_HUMAN","sp|Q15365|PCBP1_HUMAN",2586,"Q15365","PCBP1_HUMAN","Poly(rC)-binding protein 1",null,"PCBP1"]
["21.4856","21.2906","21.2759","21.7838","20.7086","20.8805",{"$nulls":3},"actin filament bundle assembly;apoptotic process;apoptotic signaling pathway;interleukin-2 biosynthetic process;negative regulation of B cell proliferation;negative regulation of fibroblast proliferation;negative regulation of T cell proliferation;negative regulation of T cell receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;positive regulation of amyloid precursor protein biosynthetic process;positive regulation of apoptotic process;positive regulation of cellular senescence;positive regulation of gene expression;positive regulation of hydrogen peroxide-mediated programmed cell death;transcription, DNA-templated","actin binding;enzyme binding;leucine zipper domain binding;transcription corepressor activity","actin filament;cytoplasm;nuclear chromatin;nucleus",{"$nulls":3},7,7,7,"35.6","35.6","35.6","36.567",0,"42.213",323510000,23,"0.265843",1,"0.226398","0.665405","sp|Q96IZ0|PAWR_HUMAN;tr|H0YHP5|H0YHP5_HUMAN;tr|H0YI16|H0YI16_HUMAN;tr|A0A0B4J260|A0A0B4J260_HUMAN;tr|F8W1M8|F8W1M8_HUMAN","sp|Q96IZ0|PAWR_HUMAN",3932,"Q96IZ0","PAWR_HUMAN","PRKC apoptosis WT1 regulator protein",null,"PAWR"]
["19.621","17.698","18.2308","19.5068","16.1232","19.2425",{"$nulls":9},5,5,5,13,13,13,"69.8",0,"14.511",129710000,9,"0.0639206",1,"0.225749","0.183767","tr|B8ZZW5|B8ZZW5_HUMAN;sp|Q8NBF6|AVL9_HUMAN;tr|H7C0I1|H7C0I1_HUMAN","tr|B8ZZW5|B8ZZW5_HUMAN;sp|Q8NBF6|AVL9_HUMAN;tr|H7C0I1|H7C0I1_HUMAN",3452,"B8ZZW5","B8ZZW5_HUMAN",null,null,"AVL9"]
["19.8392","19.2912","19.3578","20.5277","17.5042","19.7791",{"$nulls":3},"autophagosome assembly;autophagosome maturation;autophagy;autophagy of mitochondrion;cellular response to nitrogen starvation;intra-Golgi vesicle-mediated transport;macroautophagy;negative regulation of proteasomal protein catabolic process;positive regulation of ATPase activity;protein transport","ATPase binding;beta-tubulin binding;GABA receptor binding;microtubule binding;SNARE binding;ubiquitin protein ligase binding","autophagosome;autophagosome membrane;cytoplasm;cytoplasmic vesicle;cytosol;Golgi apparatus;Golgi membrane;intracellular","Apelin signaling pathway;Autophagy - animal;Autophagy - other;FoxO signaling pathway;GABAergic synapse;Kaposi sarcoma-associated herpesvirus infection;Mitophagy - animal;NOD-like receptor signaling pathway",null,null,3,3,3,"25.6","25.6","25.6","13.667",0,"6.0124",57777000,9,"0.0865713",1,"0.225747","0.243947","sp|P60520|GBRL2_HUMAN;tr|H3BQ50|H3BQ50_HUMAN;tr|H3BSM5|H3BSM5_HUMAN;tr|F5GZY7|F5GZY7_HUMAN;tr|H6UMI1|H6UMI1_HUMAN;sp|Q9H0R8|GBRL1_HUMAN;sp|O95166|GBRAP_HUMAN","sp|P60520|GBRL2_HUMAN;tr|H3BQ50|H3BQ50_HUMAN;tr|H3BSM5|H3BSM5_HUMAN",1894,"P60520","GBRL2_HUMAN","Gamma-aminobutyric acid receptor-associated protein-like 2",null,"GABARAPL2"]
["19.9282","18.3985","19.5736","19.9332","18.1591","19.1398",{"$nulls":3},"RNA processing","RNA binding","cytosol;intracellular ribonucleoprotein complex;nucleoplasm",{"$nulls":3},10,10,10,"20.4","20.4","20.4","66.898",0,"42.645",244240000,43,"0.117358",1,"0.222748","0.322528","sp|Q4G0J3|LARP7_HUMAN;tr|H0YA82|H0YA82_HUMAN;tr|D6RFF0|D6RFF0_HUMAN;tr|D6R9Z6|D6R9Z6_HUMAN;tr|D6RF49|D6RF49_HUMAN;tr|D6RAF3|D6RAF3_HUMAN","sp|Q4G0J3|LARP7_HUMAN;tr|H0YA82|H0YA82_HUMAN",2754,"Q4G0J3","LARP7_HUMAN","La-related protein 7",null,"LARP7"]
["24.1524","23.7343","24.2695","23.848","23.3643","24.283",{"$nulls":9},13,13,13,"64.4","64.4","64.4","31.703",0,"261.63",2898800000,170,"0.285708",1,"0.220307","0.708117","tr|J3QT28|J3QT28_HUMAN;sp|O43684|BUB3_HUMAN;tr|J3QSX4|J3QSX4_HUMAN","tr|J3QT28|J3QT28_HUMAN;sp|O43684|BUB3_HUMAN",445,"J3QT28","J3QT28_HUMAN",null,null,"BUB3"]
["25.132","24.4573","24.4586","24.2429","24.4088","24.7366",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},8,8,8,"51.1","51.1","51.1","15.616",0,"58.232",6059600000,242,"0.339984",1,"0.219914","0.822286","tr|D3YTB1|D3YTB1_HUMAN;sp|P62910|RL32_HUMAN;tr|F8W727|F8W727_HUMAN;tr|D3YTI8|D3YTI8_HUMAN","tr|D3YTB1|D3YTB1_HUMAN;sp|P62910|RL32_HUMAN;tr|F8W727|F8W727_HUMAN",2009,"D3YTB1","D3YTB1_HUMAN",null,null,"RPL32"]
["19.4167","18.6555","19.6324","18.704","18.4959","19.8453",{"$nulls":3},"cell cycle arrest;cell proliferation;cellular response to DNA damage stimulus;ERBB2 signaling pathway;G1/S transition of mitotic cell cycle;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;post-translational protein modification;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;viral process","calcium channel activity;receptor activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","Cul4-RING E3 ubiquitin ligase complex;Cul5-RING ubiquitin ligase complex;cytosol","Human immunodeficiency virus 1 infection;Ubiquitin mediated proteolysis",null,null,17,17,17,"26.2","26.2","26.2","90.954",0,"45.463",308480000,30,"0.160722",1,"0.219796","0.42801","sp|Q93034|CUL5_HUMAN;tr|H0YCA0|H0YCA0_HUMAN","sp|Q93034|CUL5_HUMAN",3750,"Q93034","CUL5_HUMAN","Cullin-5","UL-5","CUL5"]
["20.8709","18.163","20.4925","21.3443","17.8957","19.6327",{"$nulls":4},"ATPase activity, coupled to transmembrane movement of substances",{"$nulls":4},6,6,6,"41.1","41.1","41.1","21.921",0,"27.283",115910000,12,"0.0576689",1,"0.217929","0.166758","tr|G3V2S6|G3V2S6_HUMAN;sp|Q9Y5K8|VATD_HUMAN;tr|H0YJH8|H0YJH8_HUMAN;tr|G3V2V6|G3V2V6_HUMAN;tr|H0YJS0|H0YJS0_HUMAN;tr|G3V559|G3V559_HUMAN;tr|H0YJ55|H0YJ55_HUMAN","tr|G3V2S6|G3V2S6_HUMAN;sp|Q9Y5K8|VATD_HUMAN;tr|H0YJH8|H0YJH8_HUMAN;tr|G3V2V6|G3V2V6_HUMAN",5356,"G3V2S6","G3V2S6_HUMAN",null,null,"ATP6V1D"]
["16.3433","16.4169","15.9967","15.8802","14.7825","17.4433",{"$nulls":3},"endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","RNA binding","90S preribosome;nucleolus",{"$nulls":3},8,8,8,"14.2","14.2","14.2","82.597",0,"32.496",101470000,30,"0.0994235",1,"0.216972","0.277171","sp|Q8N9T8|KRI1_HUMAN;tr|H0YFD2|H0YFD2_HUMAN;tr|F8WFC1|F8WFC1_HUMAN;tr|H0YH26|H0YH26_HUMAN","sp|Q8N9T8|KRI1_HUMAN;tr|H0YFD2|H0YFD2_HUMAN;tr|F8WFC1|F8WFC1_HUMAN",3443,"Q8N9T8","KRI1_HUMAN","Protein KRI1 homolog",null,"KRI1"]
["17.8728","16.6975","18.8328","18.1327","16.3662","18.2582",{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},7,5,5,"7.8","6.1","6.1","125.87",0,"17.351",75325000,15,"0.0881054",1,"0.215352","0.247946","sp|O95104|SFR15_HUMAN","sp|O95104|SFR15_HUMAN",710,"O95104","SFR15_HUMAN","Splicing factor, arginine/serine-rich 15",null,"SCAF4"]
["23.6138","22.9179","23.9713","23.3434","23.0474","23.4671",{"$nulls":3},"adult locomotory behavior;cerebellar Purkinje cell layer maturation;ER to Golgi vesicle-mediated transport;intracellular protein transport;pigmentation;retrograde vesicle-mediated transport, Golgi to ER","RNA binding","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi membrane;membrane;transport vesicle",{"$nulls":3},25,25,25,"49.1","49.1","49.1","57.21",0,"305.29",3216300000,156,"0.256392",1,"0.215012","0.644884","sp|P48444|COPD_HUMAN;tr|B0YIW6|B0YIW6_HUMAN;tr|Q6P1Q5|Q6P1Q5_HUMAN;tr|E9PK34|E9PK34_HUMAN","sp|P48444|COPD_HUMAN;tr|B0YIW6|B0YIW6_HUMAN",1627,"P48444","COPD_HUMAN","Coatomer subunit delta",null,"ARCN1"]
["20.6067","19.0136","20.487","20.5673","18.8321","20.0661",{"$nulls":3},"early endosome to late endosome transport;endocytosis;synaptic vesicle to endosome fusion;vesicle fusion;viral RNA genome replication","1-phosphatidylinositol binding;calmodulin binding;GTP-dependent protein binding;nucleic acid binding;protein homodimerization activity;zinc ion binding","axonal spine;cytoplasm;cytosol;early endosome;early endosome membrane;extracellular exosome;extrinsic component of plasma membrane;membrane;presynapse;recycling endosome;serine-pyruvate aminotransferase complex","Endocytosis;Phagosome;Tuberculosis",null,null,30,30,30,"26.9","26.9","26.9","162.46",0,"169.04",883550000,87,"0.106159",1,"0.213918","0.294337","sp|Q15075|EEA1_HUMAN","sp|Q15075|EEA1_HUMAN",2557,"Q15075","EEA1_HUMAN","Early endosome antigen 1",null,"EEA1"]
["21.5895","23.0535","20.5672","21.6333","23.082","19.8572",{"$nulls":3},"branched-chain amino acid biosynthetic process;branched-chain amino acid catabolic process;cellular response to leukemia inhibitory factor;isoleucine catabolic process;leucine biosynthetic process;regulation of hormone levels;valine biosynthetic process","branched-chain-amino-acid transaminase activity;L-isoleucine transaminase activity;L-leucine transaminase activity;L-valine transaminase activity","mitochondrial matrix;mitochondrion","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Cysteine and methionine metabolism;Metabolic pathways;Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine biosynthesis;Valine, leucine and isoleucine degradation",null,null,8,8,8,"28.6","28.6","28.6","44.287",0,"22.879",773160000,19,"0.0626405",1,"0.212582","0.180298","sp|O15382|BCAT2_HUMAN;tr|B3KSI3|B3KSI3_HUMAN;tr|M0QZ10|M0QZ10_HUMAN;tr|M0QXF9|M0QXF9_HUMAN;tr|M0QZP4|M0QZP4_HUMAN;tr|M0R2K7|M0R2K7_HUMAN","sp|O15382|BCAT2_HUMAN;tr|B3KSI3|B3KSI3_HUMAN;tr|M0QZ10|M0QZ10_HUMAN;tr|M0QXF9|M0QXF9_HUMAN;tr|M0QZP4|M0QZP4_HUMAN",372,"O15382","BCAT2_HUMAN","Branched-chain-amino-acid aminotransferase, mitochondrial","CAT(m)","BCAT2"]
["22.5796","21.8106","22.4504","22.4522","21.51","22.2432",{"$nulls":3},"early endosome to Golgi transport;intracellular protein transport;lamellipodium morphogenesis;positive regulation of protein catabolic process;receptor internalization;retrograde transport, endosome to Golgi;vesicle organization","cadherin binding;epidermal growth factor receptor binding;identical protein binding;insulin receptor binding;leptin receptor binding;phosphatidylinositol binding;protein heterodimerization activity;protein homodimerization activity;transferrin receptor binding","cytoplasm;cytosol;early endosome membrane;endosome;endosome membrane;extrinsic component of membrane;Golgi apparatus;intracellular membrane-bounded organelle;lamellipodium;lysosome;membrane;protein complex;retromer complex;retromer, tubulation complex;vesicle","Endocytosis",null,null,18,16,16,"39.1","35.1","35.1","59.069",0,"103.44",1249200000,74,"0.22229",1,"0.21172","0.569636","sp|Q13596|SNX1_HUMAN;tr|H0YK42|H0YK42_HUMAN;tr|H0YK43|H0YK43_HUMAN;tr|J3KPH4|J3KPH4_HUMAN;tr|H0YKD5|H0YKD5_HUMAN;tr|H0YKL5|H0YKL5_HUMAN;tr|H0YK58|H0YK58_HUMAN","sp|Q13596|SNX1_HUMAN;tr|H0YK42|H0YK42_HUMAN",2388,"Q13596","SNX1_HUMAN","Sorting nexin-1",null,"SNX1"]
["21.5181","19.8699","20.6929","21.6193","19.698","20.1304",{"$nulls":3},"biosynthetic process","catalytic activity",{"$nulls":4},7,7,7,"34.1","34.1","34.1","33.711",0,"18.615",248830000,23,"0.100819",1,"0.211025","0.280741","tr|C9J050|C9J050_HUMAN;sp|P49585|PCY1A_HUMAN;tr|C9JEJ2|C9JEJ2_HUMAN;tr|H7C1T3|H7C1T3_HUMAN;tr|C9J2E1|C9J2E1_HUMAN;tr|C9JPY0|C9JPY0_HUMAN;tr|H7BZN1|H7BZN1_HUMAN;sp|Q9Y5K3|PCY1B_HUMAN;tr|C9JVS0|C9JVS0_HUMAN;tr|F8WAZ5|F8WAZ5_HUMAN;tr|F8WBU2|F8WBU2_HUMAN","tr|C9J050|C9J050_HUMAN;sp|P49585|PCY1A_HUMAN;tr|C9JEJ2|C9JEJ2_HUMAN;tr|H7C1T3|H7C1T3_HUMAN;tr|C9J2E1|C9J2E1_HUMAN",1664,"C9J050","C9J050_HUMAN",null,null,"PCYT1A"]
["21.5981","21.1558","22.1753","21.8804","20.8295","21.5944",{"$nulls":9},7,7,7,"34.7","34.7","34.7","32.64",0,"48.691",337240000,23,"0.184459",1,"0.208296","0.483609","tr|H3BRL3|H3BRL3_HUMAN;sp|O14562|UBFD1_HUMAN;tr|H3BUM8|H3BUM8_HUMAN","tr|H3BRL3|H3BRL3_HUMAN;sp|O14562|UBFD1_HUMAN;tr|H3BUM8|H3BUM8_HUMAN",272,"H3BRL3","H3BRL3_HUMAN",null,null,"UBFD1"]
["22.8575","19.9854","21.6903","22.562","20.0286","21.3185",{"$nulls":4},"retinal binding;retinol binding","cytoplasm",{"$nulls":3},6,6,6,44,44,44,"15.536",0,"27.849",156250000,13,"0.0653083",1,"0.207997","0.187517","sp|Q96R05|RET7_HUMAN","sp|Q96R05|RET7_HUMAN",4012,"Q96R05","RET7_HUMAN","Retinoid-binding protein 7",null,"RBP7"]
["21.5351","19.5326","21.3925","21.9607","19.3843","20.4933",{"$nulls":3},"protein depalmitoylation","carboxylic ester hydrolase activity;lysophospholipase activity;palmitoyl-(protein) hydrolase activity","cytoplasm;cytosol;extracellular exosome",{"$nulls":3},9,9,9,"45.6","45.6","45.6","26.316",0,"30.348",290740000,23,"0.0737714",1,"0.20733","0.210208","sp|Q5VWZ2|LYPL1_HUMAN","sp|Q5VWZ2|LYPL1_HUMAN",2906,"Q5VWZ2","LYPL1_HUMAN","Lysophospholipase-like protein 1",null,"LYPLAL1"]
[1,"16.178","15.4831",1,"14.9877","16.0536",{"$nulls":3},"box C/D snoRNP assembly;positive regulation of transcription from RNA polymerase II promoter;protein oligomerization;RNA processing","ATPase binding;DNA binding;identical protein binding;metal ion binding;protein binding, bridging;RNA binding","fibrillar center;nuclear matrix;nucleolus;nucleus;perichromatin fibrils;pre-snoRNP complex;presynaptic active zone;protein complex;transcription elongation factor complex",{"$nulls":3},5,5,5,"12.3","12.3","12.3","56.299",0,"26.881",174330000,26,"0.0098203",1,"0.206578","0.0298166","sp|Q9UHK0|NUFP1_HUMAN","sp|Q9UHK0|NUFP1_HUMAN",5025,"Q9UHK0","NUFP1_HUMAN","Nuclear fragile X mental retardation-interacting protein 1",null,"NUFIP1"]
["20.4544","18.6672","20.0841","20.2128","18.69","19.6843",{"$nulls":3},"tRNA-type intron splice site recognition and cleavage","tRNA-intron endonuclease activity","nucleus;tRNA-intron endonuclease complex",{"$nulls":3},5,5,5,"29.8","29.8","29.8","26.101",0,"43.047",102630000,23,"0.105566",1,"0.206209","0.292832","tr|B0V3J0|B0V3J0_HUMAN;tr|A9C4B9|A9C4B9_HUMAN;tr|A0A0G2JNK5|A0A0G2JNK5_HUMAN;tr|A0A024R4N9|A0A024R4N9_HUMAN;sp|Q9BSV6|SEN34_HUMAN;tr|E7EQB3|E7EQB3_HUMAN","tr|B0V3J0|B0V3J0_HUMAN;tr|A9C4B9|A9C4B9_HUMAN;tr|A0A0G2JNK5|A0A0G2JNK5_HUMAN;tr|A0A024R4N9|A0A024R4N9_HUMAN;sp|Q9BSV6|SEN34_HUMAN;tr|E7EQB3|E7EQB3_HUMAN",4191,"B0V3J0","B0V3J0_HUMAN",null,null,"TSEN34"]
["20.8823","18.2331","19.7825","20.7777","17.9833","19.5209",{"$nulls":9},7,7,7,"27.4","27.4","27.4","49.967",0,"67.154",136310000,17,"0.0640623",1,"0.20534","0.18415","sp|Q49AR2|CE022_HUMAN","sp|Q49AR2|CE022_HUMAN",2751,"Q49AR2","CE022_HUMAN","UPF0489 protein C5orf22",null,"C5orf22"]
["24.5453","23.3472","24.1139","24.1179","22.9152","24.3593",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;osteoblast differentiation;positive regulation of DNA-templated transcription, elongation;regulation of DNA recombination;replication fork processing;RNA export from nucleus;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus;viral process","RNA binding","catalytic step 2 spliceosome;cytosol;extracellular exosome;membrane;nuclear speck;nucleoplasm;transcription export complex","Herpes simplex virus 1 infection;mRNA surveillance pathway;RNA transport;Spliceosome",null,null,7,7,7,"43.2","43.2","43.2","26.888",0,"209.22",1828700000,79,"0.132715",1,"0.204641","0.36052","sp|Q86V81|THOC4_HUMAN;tr|E9PB61|E9PB61_HUMAN","sp|Q86V81|THOC4_HUMAN;tr|E9PB61|E9PB61_HUMAN",3228,"Q86V81","THOC4_HUMAN","THO complex subunit 4","ho4","ALYREF"]
["23.8931","21.9644","22.8263","23.8004","21.5284","22.7415",{"$nulls":3},"apoptotic process;ceramide metabolic process;inactivation of MAPK activity;meiotic cell cycle;mesoderm development;mitotic nuclear envelope reassembly;negative regulation of cell growth;negative regulation of epithelial to mesenchymal transition;negative regulation of tyrosine phosphorylation of STAT protein;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of protein serine/threonine kinase activity;protein dephosphorylation;regulation of cell adhesion;regulation of cell differentiation;regulation of DNA replication;regulation of growth;regulation of transcription, DNA-templated;regulation of Wnt signaling pathway;response to organic substance;RNA splicing;second-messenger-mediated signaling","GABA receptor binding;metal ion binding;phosphoprotein phosphatase activity;protein C-terminus binding;protein heterodimerization activity","chromosome, centromeric region;cytosol;extracellular exosome;membrane;microtubule cytoskeleton;mitochondrion;nucleus;plasma membrane;protein phosphatase type 2A complex;spindle pole","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Autophagy - animal;Autophagy - other;Chagas disease (American trypanosomiasis);Dopaminergic synapse;Hepatitis C;Hippo signaling pathway;Human papillomavirus infection;Long-term depression;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway;TGF-beta signaling pathway;Tight junction",null,null,10,10,1,"46.9","46.9","4.2","35.594",0,"187.21",1209700000,54,"0.0840927",1,"0.204546","0.237466","sp|P67775|PP2AA_HUMAN;tr|H0YC23|H0YC23_HUMAN;tr|E5RHC1|E5RHC1_HUMAN;tr|E5RFI3|E5RFI3_HUMAN;tr|E5RHP4|E5RHP4_HUMAN;tr|E7ESG8|E7ESG8_HUMAN;tr|H0YBN9|H0YBN9_HUMAN;tr|E5RI56|E5RI56_HUMAN","sp|P67775|PP2AA_HUMAN;tr|H0YC23|H0YC23_HUMAN;tr|E5RHC1|E5RHC1_HUMAN",2036,"P67775","PP2AA_HUMAN","Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform","P2A-alpha","PPP2CA"]
["20.956","18.6075","19.879","20.1682","18.5425","20.1243",{"$nulls":3},"mRNA processing","RNA binding","nucleus",{"$nulls":3},9,9,9,"23.8","23.8","23.8","56.45",0,"65.507",291470000,33,"0.0829285",1,"0.202546","0.234413","tr|B7WPG3|B7WPG3_HUMAN;tr|C9IYN3|C9IYN3_HUMAN;tr|D6W592|D6W592_HUMAN;sp|Q8WVV9|HNRLL_HUMAN;tr|C9JJZ7|C9JJZ7_HUMAN;tr|H7BXH8|H7BXH8_HUMAN;tr|H7C464|H7C464_HUMAN","tr|B7WPG3|B7WPG3_HUMAN;tr|C9IYN3|C9IYN3_HUMAN;tr|D6W592|D6W592_HUMAN;sp|Q8WVV9|HNRLL_HUMAN",3626,"B7WPG3","B7WPG3_HUMAN",null,null,"HNRNPLL"]
["16.5033","15.3122","15.6112","16.5709","14.8127","15.4378",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitinyl hydrolase activity","nucleoplasm",{"$nulls":3},8,8,8,"4.6","4.6","4.6","294.36",0,"20.563",81158000,16,"0.117128",1,"0.201774","0.321954","sp|Q9UPU5|UBP24_HUMAN","sp|Q9UPU5|UBP24_HUMAN",5181,"Q9UPU5","UBP24_HUMAN","Ubiquitin carboxyl-terminal hydrolase 24",null,"USP24"]
["24.1907","23.4855","24.4038","24.1681","22.7883","24.5196",{"$nulls":3},"activation of innate immune response;circadian rhythm;DNA recombination;DNA repair;innate immune response;mRNA processing;mRNA splicing, via spliceosome;negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;negative regulation of transcription, DNA-templated;regulation of circadian rhythm;regulation of transcription, DNA-templated;RNA splicing;transcription, DNA-templated","chromatin binding;core promoter binding;identical protein binding;RNA binding;RNA polymerase II distal enhancer sequence-specific DNA binding;transcription regulatory region sequence-specific DNA binding","membrane;nuclear matrix;nuclear speck;nucleolus;nucleoplasm;nucleus;paraspeckles;RNA polymerase II transcription factor complex",{"$nulls":3},27,27,25,"58.8","58.8","56.7","54.231",0,"294.91",4145600000,217,"0.123345",1,"0.201374","0.33743","sp|Q15233|NONO_HUMAN;tr|H7C367|H7C367_HUMAN;tr|C9JYS8|C9JYS8_HUMAN;tr|C9IZL7|C9IZL7_HUMAN;tr|C9J4X2|C9J4X2_HUMAN","sp|Q15233|NONO_HUMAN;tr|H7C367|H7C367_HUMAN",2572,"Q15233","NONO_HUMAN","Non-POU domain-containing octamer-binding protein","onO protein","NONO"]
["21.5132","20.4835","21.3217","21.3467","19.7622","21.6054",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,8,8,8,"35.1","35.1","35.1","38.632",0,"43.451",470250000,38,"0.110909",1,"0.201329","0.306347","sp|P09001|RM03_HUMAN;tr|H0Y9G6|H0Y9G6_HUMAN;tr|E7ETU7|E7ETU7_HUMAN;tr|E9PF06|E9PF06_HUMAN;tr|D6RC14|D6RC14_HUMAN","sp|P09001|RM03_HUMAN;tr|H0Y9G6|H0Y9G6_HUMAN;tr|E7ETU7|E7ETU7_HUMAN;tr|E9PF06|E9PF06_HUMAN;tr|D6RC14|D6RC14_HUMAN",978,"P09001","RM03_HUMAN","39S ribosomal protein L3, mitochondrial","3mt;RP-L3","MRPL3"]
["21.0242","19.2545","20.8841","21.0176","18.8033","20.739",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding","nucleoplasm;nucleus","Spliceosome",null,null,18,18,18,"23.1","23.1","23.1","118.29",0,"95.798",964790000,116,"0.0788483",1,"0.200993","0.223671","sp|O15042|SR140_HUMAN;tr|E7ET15|E7ET15_HUMAN;tr|E7EW00|E7EW00_HUMAN;tr|H0Y8D9|H0Y8D9_HUMAN;tr|H7C4V2|H7C4V2_HUMAN;tr|C9J5L1|C9J5L1_HUMAN;tr|U3KPT1|U3KPT1_HUMAN;tr|C9JDJ7|C9JDJ7_HUMAN","sp|O15042|SR140_HUMAN;tr|E7ET15|E7ET15_HUMAN",326,"O15042","SR140_HUMAN","U2 snRNP-associated SURP motif-containing protein",null,"U2SURP"]
["21.3228","19.6949","20.3732","20.3854","20.3648","20.0442",{"$nulls":3},"galactose catabolic process via UDP-galactose;galactose metabolic process;glucose metabolic process","aldose 1-epimerase activity;carbohydrate binding","cytoplasm;extracellular exosome","Galactose metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways",null,null,5,5,5,"21.1","21.1","21.1","37.765",0,"13.798",250940000,11,"0.153152",1,"0.198793","0.409982","sp|Q96C23|GALM_HUMAN;tr|B8ZZ75|B8ZZ75_HUMAN;tr|H7C1B5|H7C1B5_HUMAN;tr|H7C320|H7C320_HUMAN","sp|Q96C23|GALM_HUMAN;tr|B8ZZ75|B8ZZ75_HUMAN;tr|H7C1B5|H7C1B5_HUMAN",3815,"Q96C23","GALM_HUMAN","Aldose 1-epimerase",null,"GALM"]
["23.7806","22.2847","23.477","23.4406","22.162","23.346",{"$nulls":3},"activation of GTPase activity;cell division;chromosome passenger complex localization to kinetochore;establishment of protein localization;focal adhesion assembly;integrin-mediated signaling pathway;negative regulation of focal adhesion assembly;negative regulation of GTPase activity;negative regulation of substrate adhesion-dependent cell spreading;positive regulation of attachment of spindle microtubules to kinetochore;positive regulation of G2/M transition of mitotic cell cycle;regulation of cell migration;regulation of fibroblast migration;regulation of ruffle assembly;sister chromatid cohesion","microtubule binding;protein domain specific binding;protein kinase binding;Rac GTPase binding;RNA binding;small GTPase binding","chromosome, centromeric core domain;cytosol;early endosome membrane;microtubule;midbody;mitotic spindle midzone;nucleolus;plasma membrane",{"$nulls":3},22,22,22,"60.3","60.3","60.3","56.084",0,"133.88",2617800000,122,"0.117172",1,"0.197902","0.322063","sp|Q9P258|RCC2_HUMAN","sp|Q9P258|RCC2_HUMAN",4922,"Q9P258","RCC2_HUMAN","Protein RCC2",null,"RCC2"]
["19.6187","19.2477","19.3888","19.4626","18.7999","19.3993",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;negative regulation of double-strand break repair;negative regulation of histone H2A K63-linked ubiquitination;protein polyubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of embryonic development","thyroid hormone receptor binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;nuclear speck;nucleoplasm;nucleus","Ubiquitin mediated proteolysis",null,null,33,33,30,"23.3","23.3","21.1","220.43",0,"224.38",1405200000,170,"0.345582",1,"0.197805","0.833878","sp|Q14669|TRIPC_HUMAN;tr|H7C2Y1|H7C2Y1_HUMAN;tr|F8W9P3|F8W9P3_HUMAN;tr|C9JLJ5|C9JLJ5_HUMAN;tr|C9JSX9|C9JSX9_HUMAN;tr|H7C1L9|H7C1L9_HUMAN","sp|Q14669|TRIPC_HUMAN",2487,"Q14669","TRIPC_HUMAN","E3 ubiquitin-protein ligase TRIP12",null,"TRIP12"]
["21.5545","20.3668","21.3329","21.3782","20.1722","21.1124",{"$nulls":3},"ATP-dependent chromatin remodeling;chromatin assembly or disassembly;DNA methylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;regulation of fibroblast migration;regulation of signal transduction by p53 class mediator","chromatin binding;DNA binding transcription factor activity;histone deacetylase activity;histone deacetylase binding;RNA polymerase II repressing transcription factor binding;RNA polymerase II transcription factor binding;sequence-specific DNA binding;transcription factor activity, transcription factor binding;transcription regulatory region DNA binding;zinc ion binding","histone deacetylase complex;membrane;nuclear chromatin;nucleoplasm;NuRD complex;protein complex;transcription factor complex",{"$nulls":3},26,26,22,"39.5","39.5","34.1","75.022",0,"131.68",2241800000,190,"0.141362",1,"0.197098","0.381592","sp|O94776|MTA2_HUMAN","sp|O94776|MTA2_HUMAN",675,"O94776","MTA2_HUMAN","Metastasis-associated protein MTA2",null,"MTA2"]
["23.8891","22.6921","23.6073","23.9818","22.2312","23.3896",{"$nulls":3},"positive regulation of ATPase activity;social behavior","heat shock protein binding","cytoplasm;cytosol;extracellular space;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},16,16,16,"59.6","59.6","59.6","29.909",0,"280.64",5465100000,195,"0.112699",1,"0.195328","0.310853","sp|Q8WXX5|DNJC9_HUMAN","sp|Q8WXX5|DNJC9_HUMAN",3649,"Q8WXX5","DNJC9_HUMAN","DnaJ homolog subfamily C member 9","DJC9 {ECO:0000303|PubMed:17182002}","DNAJC9"]
["19.3561","18.7967","19.3249","19.3819","18.4463","19.0659",{"$nulls":3},"membrane organization;receptor-mediated endocytosis","calcium ion binding;SH3 domain binding","clathrin-coated pit;cytosol;plasma membrane",{"$nulls":3},14,14,14,"28.8","28.8","28.8","86.661",0,"54.443",323540000,47,"0.231754",1,"0.194536","0.590721","sp|Q96D71|REPS1_HUMAN;tr|H0YDT0|H0YDT0_HUMAN;tr|E9PMG1|E9PMG1_HUMAN;tr|H0YCR2|H0YCR2_HUMAN;tr|F2Z3L2|F2Z3L2_HUMAN;tr|H0YE89|H0YE89_HUMAN;tr|H7C1V2|H7C1V2_HUMAN;tr|H7C225|H7C225_HUMAN;tr|H0YCF0|H0YCF0_HUMAN;tr|H0YE73|H0YE73_HUMAN;sp|Q8NFH8|REPS2_HUMAN","sp|Q96D71|REPS1_HUMAN;tr|H0YDT0|H0YDT0_HUMAN;tr|E9PMG1|E9PMG1_HUMAN",3837,"Q96D71","REPS1_HUMAN","RalBP1-associated Eps domain-containing protein 1",null,"REPS1"]
["27.2066","24.6731","27.1331","26.7954","24.7147","26.9201",{"$nulls":9},26,26,8,"68.5","68.5","18.5","27.175",0,"323.31",14786000000,253,"0.0614012",1,"0.194197","0.176934","tr|Q5HYB6|Q5HYB6_HUMAN;tr|A0A087WWU8|A0A087WWU8_HUMAN;tr|Q5VU61|Q5VU61_HUMAN;tr|D6R904|D6R904_HUMAN;tr|D6RFM2|D6RFM2_HUMAN","tr|Q5HYB6|Q5HYB6_HUMAN;tr|A0A087WWU8|A0A087WWU8_HUMAN;tr|Q5VU61|Q5VU61_HUMAN",5606,"Q5HYB6","Q5HYB6_HUMAN",null,null,"DKFZp686J1372"]
["20.9","20.1933","20.4641","20.2738","20.3597","20.3449",{"$nulls":3},"activation of phospholipase A2 activity by calcium-mediated signaling;activation of phospholipase C activity;astrocyte activation;cell proliferation;cell surface receptor signaling pathway;cell-cell adhesion;cellular response to amino acid stimulus;cellular response to cadmium ion;cellular response to dexamethasone stimulus;cellular response to drug;cellular response to epidermal growth factor stimulus;cellular response to estradiol stimulus;cellular response to mechanical stimulus;cellular response to reactive oxygen species;cerebral cortex cell migration;circadian rhythm;digestive tract morphogenesis;diterpenoid metabolic process;embryonic placenta development;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;eyelid development in camera-type eye;hair follicle development;hydrogen peroxide metabolic process;learning or memory;liver regeneration;lung development;magnesium ion homeostasis;MAPK cascade;membrane organization;midgut development;morphogenesis of an epithelial fold;negative regulation of apoptotic process;negative regulation of cardiocyte differentiation;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of ERBB signaling pathway;negative regulation of mitotic cell cycle;negative regulation of protein catabolic process;neuron projection morphogenesis;ossification;ovulation cycle;peptidyl-tyrosine autophosphorylation;peptidyl-tyrosine phosphorylation;positive regulation of blood vessel diameter;positive regulation of bone resorption;positive regulation of catenin import into nucleus;positive regulation of cell growth;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;positive regulation of DNA repair;positive regulation of DNA replication;positive regulation of epithelial cell proliferation;positive regulation of ERK1 and ERK2 cascade;positive regulation of fibroblast proliferation;positive regulation of inflammatory response;positive regulation of MAP kinase activity;positive regulation of NIK/NF-kappaB signaling;positive regulation of nitric oxide biosynthetic process;positive regulation of peptidyl-serine phosphorylation;positive regulation of phosphorylation;positive regulation of production of miRNAs involved in gene silencing by miRNA;positive regulation of prolactin secretion;positive regulation of protein kinase B signaling;positive regulation of protein kinase C activity;positive regulation of protein localization to plasma membrane;positive regulation of protein phosphorylation;positive regulation of smooth muscle cell proliferation;positive regulation of superoxide anion generation;positive regulation of synaptic transmission, glutamatergic;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of vasoconstriction;protein autophosphorylation;protein insertion into membrane;regulation of cell motility;regulation of ERK1 and ERK2 cascade;regulation of JNK cascade;regulation of nitric-oxide synthase activity;regulation of peptidyl-tyrosine phosphorylation;regulation of phosphatidylinositol 3-kinase signaling;regulation of transcription from RNA polymerase II promoter;response to calcium ion;response to cobalamin;response to hydroxyisoflavone;response to osmotic stress;response to stress;response to UV-A;salivary gland morphogenesis;signal transduction;tongue development;translation;wound healing","actin filament binding;ATP binding;cadherin binding;calmodulin binding;chromatin binding;double-stranded DNA binding;enzyme binding;epidermal growth factor binding;epidermal growth factor-activated receptor activity;identical protein binding;integrin binding;MAP kinase kinase kinase activity;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;protein heterodimerization activity;protein kinase binding;protein phosphatase binding;protein tyrosine kinase activity;Ras guanyl-nucleotide exchange factor activity;signal transducer, downstream of receptor, with protein tyrosine kinase activity;transmembrane receptor protein tyrosine kinase activity;transmembrane signaling receptor activity;ubiquitin protein ligase binding;virus receptor activity","apical plasma membrane;basolateral plasma membrane;cell surface;clathrin-coated vesicle membrane;cytoplasm;early endosome membrane;endocytic vesicle;endoplasmic reticulum membrane;endosome;endosome membrane;extracellular space;focal adhesion;Golgi membrane;integral component of membrane;membrane;membrane raft;multivesicular body, internal vesicle lumen;nuclear membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;protein complex;receptor complex;Shc-EGFR complex;synapse","Adherens junction;Bladder cancer;Breast cancer;Calcium signaling pathway;Central carbon metabolism in cancer;Choline metabolism in cancer;Colorectal cancer;Cushing syndrome;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endocytosis;Endometrial cancer;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Estrogen signaling pathway;Focal adhesion;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis C;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Jak-STAT signaling pathway;MAPK signaling pathway;Melanoma;MicroRNAs in cancer;Non-small cell lung cancer;Oxytocin signaling pathway;Pancreatic cancer;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway",null,null,23,23,22,"27.9","27.9","26.9","134.28",0,"118.93",1012300000,64,"0.392435",1,"0.192989","0.929808","sp|P00533|EGFR_HUMAN;tr|E9PFD7|E9PFD7_HUMAN;tr|Q504U8|Q504U8_HUMAN;tr|A0A0B4J1Y5|A0A0B4J1Y5_HUMAN;tr|C9JYS6|C9JYS6_HUMAN;tr|J3KTI5|J3KTI5_HUMAN;tr|H3BLT0|H3BLT0_HUMAN;tr|A0A0A0MSE1|A0A0A0MSE1_HUMAN;sp|Q15303|ERBB4_HUMAN","sp|P00533|EGFR_HUMAN;tr|E9PFD7|E9PFD7_HUMAN;tr|Q504U8|Q504U8_HUMAN;tr|A0A0B4J1Y5|A0A0B4J1Y5_HUMAN",832,"P00533","EGFR_HUMAN","Epidermal growth factor receptor",null,"EGFR"]
["20.2568","19.2603","19.8346","20.4268","18.5412","19.8091",{"$nulls":3},"cell adhesion;mRNA 3'-end processing;mRNA export from nucleus;mRNA polyadenylation;mRNA splicing, via spliceosome;positive regulation of protein dephosphorylation;termination of RNA polymerase II transcription",null,"bicellular tight junction;cytoplasm;cytoskeleton;cytosol;nuclear stress granule;nucleoplasm;plasma membrane","mRNA surveillance pathway;Tight junction",null,null,26,26,26,"31.2","31.2","31.2","141.15",0,"88.939",656250000,58,"0.110867",1,"0.191597","0.306241","sp|Q92797|SYMPK_HUMAN;tr|A0A087WUE9|A0A087WUE9_HUMAN;tr|M0R3C7|M0R3C7_HUMAN;tr|M0QXP5|M0QXP5_HUMAN;tr|M0R1C2|M0R1C2_HUMAN;tr|M0R180|M0R180_HUMAN;tr|M0R033|M0R033_HUMAN","sp|Q92797|SYMPK_HUMAN;tr|A0A087WUE9|A0A087WUE9_HUMAN",3717,"Q92797","SYMPK_HUMAN","Symplekin",null,"SYMPK"]
["17.733","13.1627","15.9974","16.7204","13.2756","16.3266",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"7.7","7.7","7.7","78.71",0,"24.695",15202000,4,"0.0374886",1,"0.190169","0.110547","sp|Q5T2E6|CJ076_HUMAN;tr|Q5T2E7|Q5T2E7_HUMAN","sp|Q5T2E6|CJ076_HUMAN",2868,"Q5T2E6","CJ076_HUMAN","UPF0668 protein C10orf76",null,"C10orf76"]
["19.5984",1,"17.5168","19.2332",1,"17.3156",{"$nulls":3},"metabolic process","calcium ion binding;transferase activity, transferring acyl groups",{"$nulls":4},3,3,3,"7.8","7.8","7.8","54.472",0,"6.8315",39218000,4,"0.00751886",1,"0.188841","0.0228876","tr|A0A0G2JQ62|A0A0G2JQ62_HUMAN;sp|Q8NF37|PCAT1_HUMAN;tr|A0A0G2JRI7|A0A0G2JRI7_HUMAN","tr|A0A0G2JQ62|A0A0G2JQ62_HUMAN;sp|Q8NF37|PCAT1_HUMAN;tr|A0A0G2JRI7|A0A0G2JRI7_HUMAN",3499,"A0A0G2JQ62","A0A0G2JQ62_HUMAN",null,null,"LPCAT1"]
["24.0389","22.0415","23.3826","23.8062","21.8137","23.2794",{"$nulls":3},"cell proliferation;cellular heat acclimation;CENP-A containing nucleosome assembly;DNA replication;multicellular organism development;negative regulation of cell growth;negative regulation of G0 to G1 transition;negative regulation of gene expression, epigenetic;negative regulation of transcription from RNA polymerase II promoter;post-translational protein modification;regulation of signal transduction by p53 class mediator;response to steroid hormone;transcription, DNA-templated","histone deacetylase activity;RNA binding","cytosol;ESC/E(Z) complex;nucleoplasm;nucleus;NuRD complex",{"$nulls":3},18,10,10,"60.9","48.5","48.5","47.82",0,"211.37",1330400000,72,"0.0791577",1,"0.187931","0.224488","sp|Q16576|RBBP7_HUMAN;tr|E9PC52|E9PC52_HUMAN;tr|Q5JP01|Q5JP01_HUMAN;tr|Q5JP02|Q5JP02_HUMAN;tr|C9J7L0|C9J7L0_HUMAN;tr|Q5JNZ6|Q5JNZ6_HUMAN","sp|Q16576|RBBP7_HUMAN;tr|E9PC52|E9PC52_HUMAN;tr|Q5JP01|Q5JP01_HUMAN",2675,"Q16576","RBBP7_HUMAN","Histone-binding protein RBBP7",null,"RBBP7"]
["27.442","27.7095","27.5057","27.3991","27.1891","27.5077",{"$nulls":3},"cytoplasmic translation;embryo implantation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;heparin binding;RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;membrane","Ribosome",null,null,4,4,4,"18.9","18.9","18.9","17.752",0,"21.85",25040000000,73,"0.689611",1,"0.187127","1.51496","sp|P47914|RL29_HUMAN","sp|P47914|RL29_HUMAN",1616,"P47914","RL29_HUMAN","60S ribosomal protein L29",null,"RPL29"]
["20.3551","19.3357","20.3907","20.2536","19.143","20.1243",{"$nulls":3},"fibroblast growth factor receptor signaling pathway;mRNA processing;regulation of RNA splicing;RNA splicing","mRNA binding","nuclear body;nucleoplasm;nucleus",{"$nulls":3},9,9,8,"20.3","20.3","18.5","75.585",0,"56.562",424040000,33,"0.14044",1,"0.186845","0.379358","sp|Q6NXG1|ESRP1_HUMAN;tr|H0YBR2|H0YBR2_HUMAN;tr|H0YBB3|H0YBB3_HUMAN;tr|E5RI26|E5RI26_HUMAN","sp|Q6NXG1|ESRP1_HUMAN;tr|H0YBR2|H0YBR2_HUMAN;tr|H0YBB3|H0YBB3_HUMAN",2987,"Q6NXG1","ESRP1_HUMAN","Epithelial splicing regulatory protein 1",null,"ESRP1"]
["23.5941","22.5702","23.6311","23.5692","22.2045","23.4623",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;post-translational protein modification;protein transport","GDP binding;GTP binding;GTPase activity","cytosol;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;Golgi apparatus;Golgi membrane;lysosomal membrane;melanosome;nucleus","AMPK signaling pathway",null,null,10,10,4,"55.7","55.7","24.1","23.545",0,"76.064",1493800000,69,"0.121737",1,"0.186504","0.333438","sp|P61019|RAB2A_HUMAN;tr|E9PKL7|E9PKL7_HUMAN;tr|H7C125|H7C125_HUMAN","sp|P61019|RAB2A_HUMAN;tr|E9PKL7|E9PKL7_HUMAN",1910,"P61019","RAB2A_HUMAN","Ras-related protein Rab-2A",null,"RAB2A"]
["26.4236","25.1374","25.4198","26.0332","25.0889","25.3035",{"$nulls":3},"cell proliferation;cellular response to hydrogen peroxide;cellular response to UV;DNA damage response, detection of DNA damage;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA ligation;epithelial cell differentiation;error-free translesion synthesis;error-prone translesion synthesis;estrous cycle;heart development;leading strand elongation;liver regeneration;mismatch repair;mitotic telomere maintenance via semi-conservative replication;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of deoxyribonuclease activity;positive regulation of DNA repair;positive regulation of DNA replication;protein sumoylation;protein ubiquitination;regulation of transcription involved in G1/S transition of mitotic cell cycle;replication fork processing;response to cadmium ion;response to dexamethasone;response to estradiol;response to L-glutamate;telomere maintenance;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","chromatin binding;damaged DNA binding;dinucleotide insertion or deletion binding;DNA polymerase binding;DNA polymerase processivity factor activity;enzyme binding;estrogen receptor binding;histone acetyltransferase binding;identical protein binding;MutLalpha complex binding;purine-specific mismatch base pair DNA N-glycosylase activity;receptor tyrosine kinase binding","centrosome;DNA replication factor C complex;extracellular exosome;nuclear body;nuclear chromosome, telomeric region;nuclear replication fork;nucleoplasm;nucleus;PCNA complex;PCNA-p21 complex;replication fork;replisome","Base excision repair;Cell cycle;DNA replication;Hepatitis B;Mismatch repair;Nucleotide excision repair;Tight junction",null,null,13,13,13,72,72,72,"28.768",0,"323.31",8030900000,223,"0.141755",1,"0.18505","0.382547","sp|P12004|PCNA_HUMAN","sp|P12004|PCNA_HUMAN",1057,"P12004","PCNA_HUMAN","Proliferating cell nuclear antigen","CNA","PCNA"]
["20.4401","19.3983","19.6524","20.7357","18.7852","19.4185",{"$nulls":9},3,3,3,29,29,29,17,0,"20.73",118790000,11,"0.100857",1,"0.183812","0.280837","tr|E5RIP4|E5RIP4_HUMAN;sp|Q15043|S39AE_HUMAN;tr|E5RFZ8|E5RFZ8_HUMAN;tr|E5RGA7|E5RGA7_HUMAN;tr|E5RJ40|E5RJ40_HUMAN;tr|E5RJG5|E5RJG5_HUMAN","tr|E5RIP4|E5RIP4_HUMAN;sp|Q15043|S39AE_HUMAN;tr|E5RFZ8|E5RFZ8_HUMAN;tr|E5RGA7|E5RGA7_HUMAN;tr|E5RJ40|E5RJ40_HUMAN;tr|E5RJG5|E5RJG5_HUMAN",2546,"E5RIP4","E5RIP4_HUMAN",null,null,"SLC39A14"]
["27.3819","25.9516","26.3142","26.9527","25.8079","26.3431",{"$nulls":3},"binding of sperm to zona pellucida;chaperone mediated protein folding independent of cofactor;chaperone-mediated protein complex assembly;neutrophil degranulation;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;scaRNA localization to Cajal body;toxin transport","ATP binding;protein binding involved in protein folding;ubiquitin protein ligase binding;unfolded protein binding","azurophil granule lumen;cell body;chaperonin-containing T-complex;cytosol;extracellular exosome;extracellular matrix;extracellular region;microtubule;myelin sheath;zona pellucida receptor complex",{"$nulls":3},33,33,33,"78.9","78.9","78.9","57.488",0,"323.31",30802000000,589,"0.122194",1,"0.181302","0.334573","sp|P78371|TCPB_HUMAN;tr|F5GWF6|F5GWF6_HUMAN;tr|F8VQ14|F8VQ14_HUMAN","sp|P78371|TCPB_HUMAN;tr|F5GWF6|F5GWF6_HUMAN;tr|F8VQ14|F8VQ14_HUMAN",2062,"P78371","TCPB_HUMAN","T-complex protein 1 subunit beta","CP-1-beta","CCT2"]
["21.7508","20.8167","22.1738","21.6405","20.713","21.845",{"$nulls":4},"actin binding;structural molecule activity","cell junction;cytoskeleton;nucleus;plasma membrane",{"$nulls":3},37,37,35,"48.3","48.3","46.3","104.36",0,"323.31",2230100000,204,"0.124678",1,"0.180959","0.34073","tr|E9PHY5|E9PHY5_HUMAN;sp|O43491|E41L2_HUMAN;tr|E9PK52|E9PK52_HUMAN;tr|E9PII3|E9PII3_HUMAN;tr|I6L9B1|I6L9B1_HUMAN;tr|E9PQD2|E9PQD2_HUMAN;tr|E9PQN0|E9PQN0_HUMAN;tr|E9PRG1|E9PRG1_HUMAN;tr|E9PIG0|E9PIG0_HUMAN;tr|Q6R5J7|Q6R5J7_HUMAN;tr|E9PJP4|E9PJP4_HUMAN;tr|H0Y5B0|H0Y5B0_HUMAN;tr|E9PMV8|E9PMV8_HUMAN;tr|Q6ZSX4|Q6ZSX4_HUMAN;tr|E9PMG5|E9PMG5_HUMAN;tr|E9PPC9|E9PPC9_HUMAN;tr|E9PN54|E9PN54_HUMAN;tr|B2RB02|B2RB02_HUMAN;tr|A8K968|A8K968_HUMAN;tr|J3KT37|J3KT37_HUMAN","tr|E9PHY5|E9PHY5_HUMAN;sp|O43491|E41L2_HUMAN;tr|E9PK52|E9PK52_HUMAN;tr|E9PII3|E9PII3_HUMAN;tr|I6L9B1|I6L9B1_HUMAN",5514,"E9PHY5","E9PHY5_HUMAN",null,null,"EPB41L2"]
["21.8749","19.2474","21.0576","21.0483","19.6005","20.9912",{"$nulls":3},"apoptotic mitochondrial changes;cellular response to arsenic-containing substance;cellular response to calcium ion;cellular response to hydrogen peroxide;mitochondrial outer membrane permeabilization involved in programmed cell death;necroptotic process;negative regulation of apoptotic process;negative regulation of ATPase activity;negative regulation of intrinsic apoptotic signaling pathway;negative regulation of oxidative phosphorylation;negative regulation of oxidative phosphorylation uncoupler activity;negative regulation of release of cytochrome c from mitochondria;positive regulation of release of cytochrome c from mitochondria;protein folding;regulation of mitochondrial membrane permeability;regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;regulation of necrotic cell death;regulation of proton-transporting ATPase activity, rotational mechanism;response to ischemia","cyclosporin A binding;peptidyl-prolyl cis-trans isomerase activity","membrane;mitochondrial inner membrane;mitochondrial matrix;mitochondrial permeability transition pore complex;mitochondrion","Calcium signaling pathway;cGMP-PKG signaling pathway;Huntington disease;Parkinson disease;Toxoplasmosis",null,null,8,8,7,"51.2","51.2","47.8","22.04",0,"77.503",201170000,31,"0.069173",1,"0.179956","0.197918","sp|P30405|PPIF_HUMAN;tr|R4GN99|R4GN99_HUMAN;tr|H0Y548|H0Y548_HUMAN","sp|P30405|PPIF_HUMAN;tr|R4GN99|R4GN99_HUMAN;tr|H0Y548|H0Y548_HUMAN",1380,"P30405","PPIF_HUMAN","Peptidyl-prolyl cis-trans isomerase F, mitochondrial","PIase F","PPIF"]
["19.0819","18.6032","18.7277","19.4745","17.8771","18.528",{"$nulls":9},1,1,1,"4.5","4.5","4.5","41.548","0.00041127","4.0973",58257000,6,"0.135034",1,"0.177757","0.366194","tr|B9TX33|B9TX33_HUMAN;sp|Q71SY5|MED25_HUMAN","tr|B9TX33|B9TX33_HUMAN;sp|Q71SY5|MED25_HUMAN",3107,"B9TX33","B9TX33_HUMAN"]
["23.6873","22.7485","23.5116","23.5164","22.2803","23.6186",{"$nulls":3},"defense response to bacterium;embryo development;endocytic recycling;fibroblast growth factor receptor signaling pathway;Golgi to endosome transport;intracellular transport;neutrophil degranulation;phagosome maturation;phosphatidylinositol biosynthetic process;protein transport;regulation of endocytosis;regulation of protein localization;vesicle-mediated transport","GDP binding;GTP binding;GTPase activity;myosin V binding","cytosol;early endosome;early endosome membrane;extracellular exosome;Golgi membrane;Golgi stack;intracellular;intracellular membrane-bounded organelle;late endosome;lysosomal membrane;lysosome;nuclear outer membrane-endoplasmic reticulum membrane network;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;recycling endosome;recycling endosome membrane;rough endoplasmic reticulum;tertiary granule membrane;trans-Golgi network;trans-Golgi network transport vesicle","AMPK signaling pathway",null,null,12,12,12,"61.4","61.4","61.4","23.897",0,"77.362",1630800000,92,"0.125423",1,"0.177355","0.342573","sp|P61106|RAB14_HUMAN;tr|X6RFL8|X6RFL8_HUMAN","sp|P61106|RAB14_HUMAN;tr|X6RFL8|X6RFL8_HUMAN",1918,"P61106","RAB14_HUMAN","Ras-related protein Rab-14",null,"RAB14"]
["23.2119","21.6999","22.6052","23.195","21.3208","22.4701",{"$nulls":3},"abscission;cell division;cytokinesis;ESCRT III complex disassembly;establishment of protein localization;multivesicular body assembly;neutrophil degranulation;positive regulation of collateral sprouting;positive regulation of proteolysis;protein localization;protein transport;viral capsid secondary envelopment;viral release from host cell","cadherin binding;identical protein binding;MIT domain binding;protein complex binding;protein domain specific binding","azurophil granule lumen;centrosome;cytosol;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular region;Flemming body;intracellular membrane-bounded organelle;midbody;nuclear envelope","Endocytosis",null,null,12,12,3,"46.2","46.2","16.5","39.75",0,"73.444",773220000,48,"0.0899246",1,"0.177003","0.252677","sp|P53990|IST1_HUMAN","sp|P53990|IST1_HUMAN",1810,"P53990","IST1_HUMAN","IST1 homolog","IST1","IST1"]
["29.8759","28.602","29.1862","29.6492","28.3431","29.1433",{"$nulls":3},"establishment of Golgi localization;Golgi reassembly;membrane organization;negative regulation of apoptotic process;platelet activation;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein targeting;regulation of mRNA stability;signal transduction","cadherin binding;identical protein binding;ion channel binding;protein domain specific binding;protein kinase binding;RNA binding;transcription factor binding;ubiquitin protein ligase binding","blood microparticle;cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;extracellular space;focal adhesion;melanosome;mitochondrion;nucleoplasm;nucleus;vesicle","Cell cycle;Hepatitis B;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;Pathogenic Escherichia coli infection;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,21,21,17,"74.7","74.7",71,"27.745",0,"323.31",84251000000,511,"0.121506",1,"0.176168","0.332865","sp|P63104|1433Z_HUMAN;tr|E7EX29|E7EX29_HUMAN;tr|B0AZS6|B0AZS6_HUMAN;tr|E7ESK7|E7ESK7_HUMAN;tr|B7Z2E6|B7Z2E6_HUMAN;tr|H0YB80|H0YB80_HUMAN;tr|E5RIR4|E5RIR4_HUMAN;tr|E9PD24|E9PD24_HUMAN;tr|E7EVZ2|E7EVZ2_HUMAN;tr|E5RGE1|E5RGE1_HUMAN","sp|P63104|1433Z_HUMAN;tr|E7EX29|E7EX29_HUMAN;tr|B0AZS6|B0AZS6_HUMAN;tr|E7ESK7|E7ESK7_HUMAN",2022,"P63104","1433Z_HUMAN","14-3-3 protein zeta/delta",null,"YWHAZ"]
["22.0621","20.8642","21.4726","21.9671","20.5857","21.3199",{"$nulls":3},"negative regulation of mRNA polyadenylation;negative regulation of transcription elongation from RNA polymerase II promoter;positive regulation of ERK1 and ERK2 cascade;positive regulation of histone H3-K4 methylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral transcription;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","chromatin binding;RNA binding","NELF complex;nuclear body;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},11,11,11,"38.4","38.4","38.4","43.239",0,"56.166",735550000,61,"0.121245",1,"0.175412","0.332216","sp|P18615|NELFE_HUMAN;tr|A0A0A0MT02|A0A0A0MT02_HUMAN;tr|A0A0A0MSN9|A0A0A0MSN9_HUMAN;tr|A0A0G2JI50|A0A0G2JI50_HUMAN;tr|E9PD43|E9PD43_HUMAN;tr|A2ABK4|A2ABK4_HUMAN;tr|E7ENC7|E7ENC7_HUMAN;tr|E7EWR7|E7EWR7_HUMAN","sp|P18615|NELFE_HUMAN;tr|A0A0A0MT02|A0A0A0MT02_HUMAN;tr|A0A0A0MSN9|A0A0A0MSN9_HUMAN;tr|A0A0G2JI50|A0A0G2JI50_HUMAN;tr|E9PD43|E9PD43_HUMAN",1180,"P18615","NELFE_HUMAN","Negative elongation factor E","ELF-E","NELFE"]
["23.5342","22.1886","23.1619","23.3269","22.1532","22.8805",{"$nulls":3},"protein sumoylation","ATP binding;enzyme activator activity;magnesium ion binding;protein heterodimerization activity;small protein activating enzyme binding;SUMO activating enzyme activity;SUMO binding;transcription factor binding;ubiquitin-like protein conjugating enzyme binding","cytoplasm;nucleoplasm;SUMO activating enzyme complex","Ubiquitin mediated proteolysis",null,null,24,24,24,47,47,47,"71.223",0,"323.31",2181800000,103,"0.120912",1,"0.174703","0.331387","sp|Q9UBT2|SAE2_HUMAN;tr|K7ESK7|K7ESK7_HUMAN;tr|K7EPL2|K7EPL2_HUMAN;tr|U3KQ93|U3KQ93_HUMAN;tr|U3KQ55|U3KQ55_HUMAN;tr|K7ES38|K7ES38_HUMAN","sp|Q9UBT2|SAE2_HUMAN",4974,"Q9UBT2","SAE2_HUMAN","SUMO-activating enzyme subunit 2",null,"UBA2"]
["21.3506","19.704","19.9756","21.172","19.6031","19.7337",{"$nulls":3},"GDP-mannose biosynthetic process","GTP binding;mannose-1-phosphate guanylyltransferase activity","cytoplasm;extracellular exosome;mitochondrion","Amino sugar and nucleotide sugar metabolism;Fructose and mannose metabolism;Metabolic pathways",null,null,7,7,7,"24.7","24.7","24.7","39.834",0,"29.014",262010000,22,"0.0861391",1,"0.173814","0.242819","sp|Q9Y5P6|GMPPB_HUMAN","sp|Q9Y5P6|GMPPB_HUMAN",5362,"Q9Y5P6","GMPPB_HUMAN","Mannose-1-phosphate guanyltransferase beta",null,"GMPPB"]
["25.1719","24.1156","24.8561","24.9692","23.9324","24.7216",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of endopeptidase activity;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex;synapse","Proteasome",null,null,10,10,10,"46.3","46.3","46.3","28.433",0,"103.19",3426900000,85,"0.145759",1,"0.173522","0.392227","sp|P25788|PSA3_HUMAN;tr|G3V4X5|G3V4X5_HUMAN;tr|G3V3W4|G3V3W4_HUMAN;tr|G3V5N4|G3V5N4_HUMAN;tr|H0YJ03|H0YJ03_HUMAN","sp|P25788|PSA3_HUMAN",1297,"P25788","PSA3_HUMAN","Proteasome subunit alpha type-3",null,"PSMA3"]
["22.8988","21.3065","21.4361","22.6246","21.1573","21.3437",{"$nulls":3},"asparagine biosynthetic process;cellular amino acid biosynthetic process;cellular response to glucose starvation;cellular response to hormone stimulus;glutamine metabolic process;L-asparagine biosynthetic process;liver development;negative regulation of apoptotic process;PERK-mediated unfolded protein response;positive regulation of mitotic cell cycle;response to amino acid;response to follicle-stimulating hormone;response to light stimulus;response to mechanical stimulus;response to methotrexate;response to toxic substance","asparagine synthase (glutamine-hydrolyzing) activity;ATP binding;cofactor binding;protein homodimerization activity","cytosol","Alanine, aspartate and glutamate metabolism;Biosynthesis of amino acids;Metabolic pathways",null,null,26,26,26,"54.9","54.9","54.9","64.369",0,"322.05",2503100000,124,"0.0888667",1,"0.171954","0.249928","sp|P08243|ASNS_HUMAN;tr|F8WEJ5|F8WEJ5_HUMAN;tr|C9J057|C9J057_HUMAN;tr|C9JT45|C9JT45_HUMAN;tr|C9JM09|C9JM09_HUMAN;tr|C9JLN6|C9JLN6_HUMAN","sp|P08243|ASNS_HUMAN;tr|F8WEJ5|F8WEJ5_HUMAN",962,"P08243","ASNS_HUMAN","Asparagine synthetase [glutamine-hydrolyzing]",null,"ASNS"]
["20.2261","18.4755","20.0699","19.2323","19.2044","19.8204",{"$nulls":3},"cellular response to misfolded protein;DNA repair;endoplasmic reticulum unfolded protein response;ERBB2 signaling pathway;negative regulation of protein binding;negative regulation of transforming growth factor beta receptor signaling pathway;positive regulation of chaperone-mediated protein complex assembly;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein ubiquitination;positive regulation of ubiquitin-protein transferase activity;proteasome-mediated ubiquitin-dependent protein catabolic process;protein autoubiquitination;protein K63-linked ubiquitination;protein maturation;protein polyubiquitination;protein quality control for misfolded or incompletely synthesized proteins;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of glucocorticoid metabolic process;regulation of protein stability;ubiquitin-dependent protein catabolic process;ubiquitin-dependent SMAD protein catabolic process","enzyme binding;G-protein coupled receptor binding;Hsp70 protein binding;Hsp90 protein binding;kinase binding;misfolded protein binding;protein binding, bridging;protein homodimerization activity;SMAD binding;TPR domain binding;ubiquitin protein ligase activity;ubiquitin protein ligase activity involved in ERAD pathway;ubiquitin protein ligase binding;ubiquitin-protein transferase activity;ubiquitin-ubiquitin ligase activity","cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;nuclear inclusion body;nucleoplasm;ubiquitin conjugating enzyme complex;ubiquitin ligase complex;Z disc","Protein processing in endoplasmic reticulum;Ubiquitin mediated proteolysis",null,null,7,7,7,"28.1","28.1","28.1","34.856",0,"23.83",206230000,15,"0.103858",1,"0.171445","0.288492","sp|Q9UNE7|CHIP_HUMAN;tr|H3BTA3|H3BTA3_HUMAN;tr|H3BUD0|H3BUD0_HUMAN;tr|H3BS86|H3BS86_HUMAN","sp|Q9UNE7|CHIP_HUMAN",5149,"Q9UNE7","CHIP_HUMAN","E3 ubiquitin-protein ligase CHIP {ECO:0000305}",null,"STUB1"]
["25.4434","24.2556","24.8914","25.434","23.8846","24.7604",{"$nulls":3},"beta-catenin-TCF complex assembly;box C/D snoRNP assembly;cell cycle;cell division;CENP-A containing nucleosome assembly;chromatin remodeling;DNA recombination;DNA repair;histone H2A acetylation;histone H4 acetylation;positive regulation of protein targeting to mitochondrion;positive regulation of telomerase RNA localization to Cajal body;protein deubiquitination;regulation of autophagy of mitochondrion;regulation of growth;regulation of transcription from RNA polymerase II promoter;spermatogenesis;transcription, DNA-templated","ADP binding;ATP binding;ATPase activity;ATPase binding;ATP-dependent 5'-3' DNA helicase activity;ATP-dependent DNA helicase activity;cadherin binding;DNA helicase activity;TFIID-class transcription factor binding","cytosol;extracellular exosome;Ino80 complex;intracellular ribonucleoprotein complex;membrane;microtubule organizing center;MLL1 complex;NuA4 histone acetyltransferase complex;nuclear matrix;nucleoplasm;nucleus;R2TP complex;Swr1 complex","Wnt signaling pathway",null,null,21,21,21,"65.8","65.8","65.8","50.227",0,"323.31",7733400000,312,"0.109127",1,"0.170474","0.301851","sp|Q9Y265|RUVB1_HUMAN;tr|E7ETR0|E7ETR0_HUMAN;tr|H7C4G5|H7C4G5_HUMAN;tr|H7C4I3|H7C4I3_HUMAN;tr|J3QLR1|J3QLR1_HUMAN","sp|Q9Y265|RUVB1_HUMAN;tr|E7ETR0|E7ETR0_HUMAN",5205,"Q9Y265","RUVB1_HUMAN","RuvB-like 1",null,"RUVBL1"]
["20.5164","19.031","18.9986","20.6804","17.8512","19.5044",{"$nulls":3},"positive regulation of protein binding;positive regulation of protein localization to nucleolus;positive regulation of RNA biosynthetic process;ribosomal large subunit export from nucleus","protein binding, bridging;ribosomal large subunit binding;RNA binding","cytoplasm;membrane;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes;RNA transport",null,null,8,8,8,"24.1","24.1","24.1","57.603",0,"37.545",228810000,25,"0.0613829",1,"0.170026","0.176884","sp|Q96D46|NMD3_HUMAN;tr|C9JA08|C9JA08_HUMAN;tr|C9J0B9|C9J0B9_HUMAN;tr|C9IZW9|C9IZW9_HUMAN;tr|C9K0C2|C9K0C2_HUMAN;tr|C9IY70|C9IY70_HUMAN","sp|Q96D46|NMD3_HUMAN;tr|C9JA08|C9JA08_HUMAN",3834,"Q96D46","NMD3_HUMAN","60S ribosomal export protein NMD3","NMD3","NMD3"]
["22.4566","20.8083","22.2445","23.0449","19.8748","22.085",{"$nulls":4},"SH3 domain binding;structural constituent of cytoskeleton","cytoskeleton;cytosol","Pathways in cancer;Thyroid cancer",null,null,19,19,19,47,47,47,"53.29",0,"164.03",961410000,64,"0.0541018",1,"0.168252","0.15697","sp|Q16204|CCDC6_HUMAN","sp|Q16204|CCDC6_HUMAN",2659,"Q16204","CCDC6_HUMAN","Coiled-coil domain-containing protein 6",null,"CCDC6"]
["22.8754","22.031","22.1599","23.0476","21.5699","21.9449",{"$nulls":3},"cell-cell adhesion","cadherin binding","plasma membrane",{"$nulls":3},33,33,33,"46.1","46.1","46.1","104.85",0,"323.31",2951800000,186,"0.118692",1,"0.167946","0.325859","tr|C9JZR2|C9JZR2_HUMAN;sp|O60716|CTND1_HUMAN;tr|E9PRE2|E9PRE2_HUMAN;tr|E9PKY0|E9PKY0_HUMAN;tr|H0YC95|H0YC95_HUMAN;tr|E9PKL1|E9PKL1_HUMAN","tr|C9JZR2|C9JZR2_HUMAN;sp|O60716|CTND1_HUMAN",518,"C9JZR2","C9JZR2_HUMAN",null,null,"CTNND1"]
["23.3354","22.0265","22.6248","23.0565","21.9348","22.4939",{"$nulls":9},3,3,3,"60.9","60.9","60.9","10.2",0,"76.038",299590000,24,"0.122646",1,"0.167164","0.335696","tr|Q5VTU3|Q5VTU3_HUMAN;sp|P63172|DYLT1_HUMAN","tr|Q5VTU3|Q5VTU3_HUMAN;sp|P63172|DYLT1_HUMAN",2026,"Q5VTU3","Q5VTU3_HUMAN"]
["21.4494","15.9129","18.6941","21.2016","15.1354","19.2243",{"$nulls":3},"memory;negative regulation of translational initiation;regulation of long-term synaptic potentiation;spermatogenesis","mRNA binding;translation repressor activity","cytoplasm",{"$nulls":3},1,1,1,"23.6","23.6","23.6","14.984","0.00042382","4.6651",36004000,4,"0.0230034",1,"0.165032","0.0688533","sp|Q9BPZ3|PAIP2_HUMAN","sp|Q9BPZ3|PAIP2_HUMAN",4132,"Q9BPZ3","PAIP2_HUMAN","Polyadenylate-binding protein-interacting protein 2","ABP-interacting protein 2;AIP-2;oly(A)-binding protein-interacting protein 2","PAIP2"]
["19.7403","18.8245","20.1651","19.2536","19.186","19.7975",{"$nulls":3},"activation of GTPase activity;intracellular protein transport;regulation of GTPase activity;regulation of vesicle fusion;retrograde transport, endosome to Golgi","GTPase activator activity;Rab GTPase binding","cytosol;endomembrane system;intracellular;plasma membrane",{"$nulls":3},19,19,19,36,36,36,"87.198",0,"214.18",1430000000,120,"0.137845",1,"0.164277","0.373048","sp|Q4KMP7|TB10B_HUMAN;tr|H3BSE1|H3BSE1_HUMAN","sp|Q4KMP7|TB10B_HUMAN",2758,"Q4KMP7","TB10B_HUMAN","TBC1 domain family member 10B",null,"TBC1D10B"]
["20.6625","20.3948","20.521","19.9742","20.1118","21.007",{"$nulls":3},"cell proliferation;cellular response to cytokine stimulus;DNA repair;negative regulation of cell cycle arrest;negative regulation of mRNA polyadenylation;phosphorylation of RNA polymerase II C-terminal domain;positive regulation of cardiac muscle hypertrophy;positive regulation of histone H2B ubiquitination;positive regulation of histone phosphorylation;positive regulation of mRNA 3'-UTR binding;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral transcription;protein phosphorylation;regulation of DNA repair;regulation of histone modification;regulation of muscle cell differentiation;replication fork processing;response to drug;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","7SK snRNA binding;ATP binding;chromatin binding;cyclin binding;cyclin-dependent protein serine/threonine kinase activity;DNA binding;kinase activity;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity;RNA polymerase II core promoter sequence-specific DNA binding;transcription coactivator binding;transcription regulatory region DNA binding","chromosome;cyclin/CDK positive transcription elongation factor complex;cytoplasmic ribonucleoprotein granule;membrane;nucleoplasm;PML body;transcription elongation factor complex","Transcriptional misregulation in cancer",null,null,12,11,11,"35.2","33.1","33.1","42.777",0,"110.6",641890000,54,"0.185436",1,"0.161739","0.485869","sp|P50750|CDK9_HUMAN;tr|X6RE90|X6RE90_HUMAN;tr|H0YAZ9|H0YAZ9_HUMAN;tr|E7EUK8|E7EUK8_HUMAN;tr|E5RGN0|E5RGN0_HUMAN;sp|Q96Q40|CDK15_HUMAN;tr|A0A087WZU2|A0A087WZU2_HUMAN;sp|O94921|CDK14_HUMAN;tr|F5H6Z0|F5H6Z0_HUMAN;sp|Q07002|CDK18_HUMAN;sp|Q00536|CDK16_HUMAN;sp|Q00537|CDK17_HUMAN","sp|P50750|CDK9_HUMAN",1718,"P50750","CDK9_HUMAN","Cyclin-dependent kinase 9",null,"CDK9"]
["19.4824","17.004","19.1846","18.9704","16.9634","19.252",{"$nulls":3},"ubiquitin-dependent protein catabolic process","transcription factor binding","cytosol;nucleoplasm;proteasome regulatory particle, base subcomplex",{"$nulls":3},10,1,1,"42.9","7.4","7.4","41.079",0,"16.94",46101000,3,"0.0523599",1,"0.16172","0.152168","tr|Q5VWC4|Q5VWC4_HUMAN","tr|Q5VWC4|Q5VWC4_HUMAN",5617,"Q5VWC4","Q5VWC4_HUMAN"]
["22.1874","21.8373","22.5728","22.1353","21.4585","22.5227",{"$nulls":3},"ER-associated misfolded protein catabolic process;regulation of apoptotic process","ATPase binding;chaperone binding;dolichyl-phosphate-mannose-protein mannosyltransferase activity;misfolded protein binding","endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;endoplasmic reticulum membrane",{"$nulls":3},7,7,7,"43.9","43.9","43.9","23.598",0,"94.188",567420000,34,"0.159758",1,"0.16033","0.425723","sp|Q9HCN8|SDF2L_HUMAN","sp|Q9HCN8|SDF2L_HUMAN",4601,"Q9HCN8","SDF2L_HUMAN","Stromal cell-derived factor 2-like protein 1","DF2-like protein 1","SDF2L1"]
["18.3849","17.7595","18.5973","18.6552","16.867","18.7417",{"$nulls":9},7,7,7,"15.1","15.1","15.1","83.069",0,"21.501",80801000,8,"0.0854541",1,"0.159249","0.241029","sp|Q8IYQ7|THNS1_HUMAN","sp|Q8IYQ7|THNS1_HUMAN",3343,"Q8IYQ7","THNS1_HUMAN","Threonine synthase-like 1","SH1","THNSL1"]
["28.043","26.8707","27.8254","27.8428","26.6002","27.8209",{"$nulls":3},"CTP biosynthetic process;GTP biosynthetic process;UTP biosynthetic process","ATP binding;nucleoside diphosphate kinase activity","cytosol",{"$nulls":3},17,17,7,"71.9","71.9",24,"32.642",0,"276.07",34774000000,569,"0.104488",1,"0.158416","0.290094","tr|Q32Q12|Q32Q12_HUMAN;sp|P22392|NDKB_HUMAN;tr|J3KPD9|J3KPD9_HUMAN;sp|O60361|NDK8_HUMAN;tr|F6XY72|F6XY72_HUMAN","tr|Q32Q12|Q32Q12_HUMAN;sp|P22392|NDKB_HUMAN;tr|J3KPD9|J3KPD9_HUMAN",5605,"Q32Q12","Q32Q12_HUMAN","Nucleoside diphosphate kinase {ECO:0000256|RuleBase:RU004013}"]
["22.8429","21.6218","22.2758","22.8677","21.2595","22.1386",{"$nulls":3},"peptide metabolic process;protein polyubiquitination","metal ion binding;metalloendopeptidase activity;peptide binding","cytosol;mitochondrial intermembrane space","African trypanosomiasis;Renin-angiotensin system",null,null,22,22,22,"41.2","41.2","41.2","78.839",0,"157.42",1654400000,115,"0.097057",1,"0.158218","0.2711","sp|P52888|THOP1_HUMAN;tr|K7EP46|K7EP46_HUMAN;tr|K7EKB6|K7EKB6_HUMAN;tr|K7EL02|K7EL02_HUMAN;tr|K7EMU4|K7EMU4_HUMAN;tr|K7EIK4|K7EIK4_HUMAN;tr|K7EL32|K7EL32_HUMAN","sp|P52888|THOP1_HUMAN;tr|K7EP46|K7EP46_HUMAN",1784,"P52888","THOP1_HUMAN","Thimet oligopeptidase",null,"THOP1"]
["18.3113","16.6037",1,"18.0554","16.3883",1,{"$nulls":3},"synaptic vesicle docking",null,"integral component of membrane;presynapse",{"$nulls":3},1,1,1,"6.9","6.9","6.9","23.243","0.00042544","4.7725",16485000,2,"0.00666917",1,"0.157149","0.0203204","tr|A0A0C4DGE4|A0A0C4DGE4_HUMAN;tr|F8W9Y0|F8W9Y0_HUMAN;tr|A0A0J9YW33|A0A0J9YW33_HUMAN;sp|Q13277|STX3_HUMAN","tr|A0A0C4DGE4|A0A0C4DGE4_HUMAN;tr|F8W9Y0|F8W9Y0_HUMAN;tr|A0A0J9YW33|A0A0J9YW33_HUMAN;sp|Q13277|STX3_HUMAN",2334,"A0A0C4DGE4","A0A0C4DGE4_HUMAN",null,null,"STX3"]
["23.2312","21.3524","22.6503","22.7071","21.0307","23.0255",{"$nulls":3},"autophagy of mitochondrion;multicellular organism aging;regulation of autophagy","2 iron, 2 sulfur cluster binding;metal ion binding;protein homodimerization activity;RNA binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;mitochondrial outer membrane;protein complex",{"$nulls":3},7,7,7,"47.4","47.4","47.4","15.278",0,"54.512",701560000,59,"0.0657433",1,"0.156885","0.188691","sp|Q8N5K1|CISD2_HUMAN;tr|I3L1N9|I3L1N9_HUMAN;tr|D6RCF4|D6RCF4_HUMAN","sp|Q8N5K1|CISD2_HUMAN;tr|I3L1N9|I3L1N9_HUMAN",3415,"Q8N5K1","CISD2_HUMAN","CDGSH iron-sulfur domain-containing protein 2",null,"CISD2"]
["22.1732","20.5883","21.8362","22.0484","20.3585","21.7234",{"$nulls":4},"actin binding;ATP binding;motor activity","myosin complex",{"$nulls":3},42,42,42,"38.2","38.2","38.2","145.01",0,"323.31",2157300000,199,"0.0775494",1,"0.15579","0.220237","tr|A0A0A0MRM8|A0A0A0MRM8_HUMAN;sp|Q9UM54|MYO6_HUMAN;tr|E7EW20|E7EW20_HUMAN;tr|A0A0D9SGC1|A0A0D9SGC1_HUMAN;tr|Q5JVM0|Q5JVM0_HUMAN","tr|A0A0A0MRM8|A0A0A0MRM8_HUMAN;sp|Q9UM54|MYO6_HUMAN;tr|E7EW20|E7EW20_HUMAN;tr|A0A0D9SGC1|A0A0D9SGC1_HUMAN",5448,"A0A0A0MRM8","A0A0A0MRM8_HUMAN",null,null,"MYO6"]
["23.4124","21.2388","22.4991","22.7577","21.2171","22.7113",{"$nulls":3},"ER to Golgi vesicle-mediated transport;establishment of Golgi localization;intracellular protein transport;organelle transport along microtubule;retrograde vesicle-mediated transport, Golgi to ER","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;transport vesicle",{"$nulls":3},29,29,27,"47.9","47.9","44.6","97.717",0,"323.31",2816700000,180,"0.0667776",1,"0.154737","0.191479","sp|Q9Y678|COPG1_HUMAN;tr|H0Y8X7|H0Y8X7_HUMAN;tr|D6RG17|D6RG17_HUMAN;tr|H0Y8G2|H0Y8G2_HUMAN","sp|Q9Y678|COPG1_HUMAN",5393,"Q9Y678","COPG1_HUMAN","Coatomer subunit gamma-1",null,"COPG1"]
["23.4885","22.146","23.9923","22.9827","21.925","24.2607",{"$nulls":3},"chromatin silencing at telomere;DNA packaging;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;histone H4 acetylation;internal protein amino acid acetylation;response to nutrient","H4 histone acetyltransferase activity;histone acetyltransferase activity;histone binding","cytoplasm;intracellular membrane-bounded organelle;nuclear chromatin;nuclear chromosome, telomeric region;nuclear matrix;nucleoplasm;nucleus;protein complex","Alcoholism",null,null,11,11,11,"35.1","35.1","35.1","49.512",0,"173.44",1553000000,80,"0.0608258",1,"0.152842","0.175369","sp|O14929|HAT1_HUMAN;tr|F8W9G7|F8W9G7_HUMAN;tr|F8WEW1|F8WEW1_HUMAN","sp|O14929|HAT1_HUMAN",310,"O14929","HAT1_HUMAN","Histone acetyltransferase type B catalytic subunit",null,"HAT1"]
["28.3759","27.5605","27.9259","28.2766","27.2389","27.8908",{"$nulls":3},"chaperone-mediated autophagy;chaperone-mediated protein complex assembly;ciliary basal body-plasma membrane docking;ERBB2 signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;G2/M transition of mitotic cell cycle;mitochondrial transport;neutrophil degranulation;positive regulation of nitric oxide biosynthetic process;positive regulation of telomerase activity;protein import into mitochondrial outer membrane;protein refolding;protein stabilization;protein unfolding;receptor-mediated endocytosis;regulation of cellular response to heat;regulation of G2/M transition of mitotic cell cycle;regulation of nitric-oxide synthase activity;regulation of protein complex assembly;regulation of protein ubiquitination;response to antibiotic;response to cold;response to heat;response to unfolded protein;signal transduction;telomerase holoenzyme complex assembly;telomere maintenance via telomerase;vascular endothelial growth factor receptor signaling pathway","ATP binding;ATPase activity;disordered domain specific binding;DNA polymerase binding;GTPase binding;histone deacetylase binding;identical protein binding;MHC class II protein complex binding;nitric-oxide synthase regulator activity;nucleotide binding;protein homodimerization activity;protein tyrosine kinase activity;protein tyrosine kinase binding;RNA binding;TPR domain binding;unfolded protein binding","cytoplasm;cytosol;endocytic vesicle lumen;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;lysosomal lumen;melanosome;membrane;myelin sheath;nucleoplasm;nucleus;plasma membrane;protein complex;ruffle membrane;secretory granule lumen","Antigen processing and presentation;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;IL-17 signaling pathway;Necroptosis;NOD-like receptor signaling pathway;Pathways in cancer;PI3K-Akt signaling pathway;Progesterone-mediated oocyte maturation;Prostate cancer;Protein processing in endoplasmic reticulum;Th17 cell differentiation",null,null,45,31,31,"68.7",48,48,"84.659",0,"323.31",86106000000,1261,"0.147353",1,"0.152016","0.396067","sp|P07900|HS90A_HUMAN;tr|G3V2J8|G3V2J8_HUMAN;sp|Q14568|HS902_HUMAN;sp|Q58FG0|HS905_HUMAN","sp|P07900|HS90A_HUMAN",946,"P07900","HS90A_HUMAN","Heat shock protein HSP 90-alpha",null,"HSP90AA1"]
["18.6758","17.8105","19.2744","18.7745","17.413","19.1174",{"$nulls":3},"developmental process;glycerophospholipid catabolic process;phosphatidylcholine metabolic process","lysophospholipase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane","Glycerophospholipid metabolism",null,null,36,36,36,"35.1","35.1","35.1","149.99",0,"235.79",1742300000,171,"0.079762",1,"0.151912","0.226083","sp|Q8IY17|PLPL6_HUMAN;tr|M0R2C2|M0R2C2_HUMAN;tr|M0R2H4|M0R2H4_HUMAN;tr|M0R2K2|M0R2K2_HUMAN;tr|M0QYF5|M0QYF5_HUMAN;tr|M0QZK5|M0QZK5_HUMAN;tr|M0QYT1|M0QYT1_HUMAN;tr|M0QXH7|M0QXH7_HUMAN;sp|Q6ZV29|PLPL7_HUMAN","sp|Q8IY17|PLPL6_HUMAN",3328,"Q8IY17","PLPL6_HUMAN","Neuropathy target esterase",null,"PNPLA6"]
["28.4057","27.0967","28.207","28.3846","26.7021","28.1703",{"$nulls":3},"activation of MAPK activity;anaphase-promoting complex-dependent catabolic process;cellular iron ion homeostasis;cellular protein metabolic process;DNA damage response, detection of DNA damage;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;endoplasmic reticulum mannose trimming;endosomal transport;entry of bacterium into host cell;ERBB2 signaling pathway;error-free translesion synthesis;error-prone translesion synthesis;Fc-epsilon receptor signaling pathway;fibroblast growth factor receptor signaling pathway;G2/M transition of mitotic cell cycle;global genome nucleotide-excision repair;glycogen biosynthetic process;I-kappaB kinase/NF-kappaB signaling;innate immune response;interstrand cross-link repair;intracellular transport of virus;ion transmembrane transport;JNK cascade;macroautophagy;MAPK cascade;membrane organization;MyD88-dependent toll-like receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway;negative regulation of apoptotic process;negative regulation of canonical Wnt signaling pathway;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transforming growth factor beta receptor signaling pathway;negative regulation of type I interferon production;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;Notch signaling pathway;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleotide-binding oligomerization domain containing signaling pathway;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;positive regulation of apoptotic process;positive regulation of canonical Wnt signaling pathway;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein folding;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of necroptotic process;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter in response to hypoxia;regulation of tumor necrosis factor-mediated signaling pathway;regulation of type I interferon production;rRNA processing;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;SRP-dependent cotranslational protein targeting to membrane;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;transcription-coupled nucleotide-excision repair;transforming growth factor beta receptor signaling pathway;translation;translational initiation;translesion synthesis;transmembrane transport;TRIF-dependent toll-like receptor signaling pathway;tumor necrosis factor-mediated signaling pathway;viral life cycle;viral transcription;virion assembly;Wnt signaling pathway;Wnt signaling pathway, planar cell polarity pathway","metal ion binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic small ribosomal subunit;endocytic vesicle membrane;endoplasmic reticulum membrane;endoplasmic reticulum quality control compartment;endosome membrane;extracellular exosome;extracellular space;host cell;membrane;mitochondrial outer membrane;myelin sheath;nucleolus;nucleoplasm;nucleus;plasma membrane;small ribosomal subunit;vesicle","Ribosome",null,null,7,7,2,"51.9","51.9","20.5","17.965",0,"124.35",17721000000,213,"0.0797106",1,"0.150799","0.225947","sp|P62979|RS27A_HUMAN","sp|P62979|RS27A_HUMAN",2014,"P62979","RS27A_HUMAN","Ubiquitin-40S ribosomal protein S27a",null,"RPS27A"]
["20.8783","20.5752","21.1358","20.8639","20.4213","20.8573",{"$nulls":3},"tRNA modification;tRNA N2-guanine methylation","metal ion binding;RNA binding;tRNA (guanine-N2-)-methyltransferase activity;tRNA binding","mitochondrion;nucleoplasm;nucleus",{"$nulls":3},10,10,10,"22.2","22.2","22.2","72.233",0,"48.384",577490000,43,"0.273606",1,"0.148958","0.682163","sp|Q9NXH9|TRM1_HUMAN;tr|K7EQQ8|K7EQQ8_HUMAN;tr|K7EQY6|K7EQY6_HUMAN;tr|K7EMZ2|K7EMZ2_HUMAN;tr|K7ENI9|K7ENI9_HUMAN;tr|K7EQU7|K7EQU7_HUMAN;tr|K7ERR5|K7ERR5_HUMAN","sp|Q9NXH9|TRM1_HUMAN;tr|K7EQQ8|K7EQQ8_HUMAN",4829,"Q9NXH9","TRM1_HUMAN","tRNA (guanine(26)-N(2))-dimethyltransferase",null,"TRMT1"]
["21.4641","18.233","20.7636","21.5072","17.9138","20.5935",{"$nulls":3},"fatty acid catabolic process","acyl-CoA hydrolase activity;metal ion binding;receptor binding","mitochondrion;peroxisomal matrix","Peroxisome",null,null,8,8,8,"34.4","34.4","34.4","42.233",0,"76.154",259160000,27,"0.0344909",1,"0.148737","0.102016","sp|A8MXV4|NUD19_HUMAN","sp|A8MXV4|NUD19_HUMAN",193,"A8MXV4","NUD19_HUMAN","Nucleoside diphosphate-linked moiety X motif 19","udix motif 19","NUDT19"]
["23.313","21.6145","23.2603","22.9463","21.5899","23.2062",{"$nulls":3},"actin filament polymerization;Arp2/3 complex-mediated actin nucleation;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component;positive regulation of lamellipodium assembly;positive regulation of substrate adhesion-dependent cell spreading","actin binding;structural constituent of cytoskeleton","actin cytoskeleton;Arp2/3 protein complex;cell leading edge;cytosol;endosome;extracellular exosome;focal adhesion;muscle cell projection membrane;neuron projection;synapse","Bacterial invasion of epithelial cells;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,17,17,17,"68.7","68.7","68.7","34.333",0,"262.19",1300200000,69,"0.0692145",1,"0.148455","0.19803","sp|O15144|ARPC2_HUMAN;tr|C9JTV5|C9JTV5_HUMAN;tr|G5E9J0|G5E9J0_HUMAN;tr|H7C3F9|H7C3F9_HUMAN;tr|G5E9S7|G5E9S7_HUMAN","sp|O15144|ARPC2_HUMAN",338,"O15144","ARPC2_HUMAN","Actin-related protein 2/3 complex subunit 2",null,"ARPC2"]
["20.346","20.5965","20.2633","20.1437","20.138","20.4811",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion","Ribosome",null,null,13,13,13,"28.8","28.8","28.8","48.006",0,"42.372",604860000,38,"0.415242",1,"0.147685","0.97589","sp|P82675|RT05_HUMAN","sp|P82675|RT05_HUMAN",2078,"P82675","RT05_HUMAN","28S ribosomal protein S5, mitochondrial","5mt;RP-S5","MRPS5"]
["17.4365","16.4209","16.947","17.7379","15.9772","16.6509",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","RNA binding","nucleolus;nucleus",{"$nulls":3},16,16,16,"31.7","31.7","31.7","84.468",0,"85.278",331890000,33,"0.0878582",1,"0.146112","0.247302","sp|Q5QJE6|TDIF2_HUMAN;tr|J3KP30|J3KP30_HUMAN;tr|E9PRB3|E9PRB3_HUMAN","sp|Q5QJE6|TDIF2_HUMAN;tr|J3KP30|J3KP30_HUMAN",2840,"Q5QJE6","TDIF2_HUMAN","Deoxynucleotidyltransferase terminal-interacting protein 2",null,"DNTTIP2"]
["20.6299","18.557","17.5669","21.0399","18.2703","17.0085",{"$nulls":3},"endosomal transport;macroautophagy;multivesicular body assembly;negative regulation of epidermal growth factor-activated receptor activity;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;regulation of transcription, DNA-templated;transcription, DNA-templated","protein homodimerization activity;protein N-terminus binding;structural molecule activity","cytoplasm;cytosol;endosome membrane;ESCRT II complex;extracellular exosome;nucleoplasm;nucleus","Endocytosis",null,null,5,5,5,"31.2","31.2","31.2","20.747",0,"8.2728",80404000,7,"0.0327512",1,"0.144976","0.0970419","sp|Q9BRG1|VPS25_HUMAN;tr|K7EKV4|K7EKV4_HUMAN;tr|K7ENE3|K7ENE3_HUMAN;tr|K7EP45|K7EP45_HUMAN","sp|Q9BRG1|VPS25_HUMAN;tr|K7EKV4|K7EKV4_HUMAN",4160,"Q9BRG1","VPS25_HUMAN","Vacuolar protein-sorting-associated protein 25","Vps25","VPS25"]
["21.5456","20.3425","20.4866","21.6153","19.8794","20.4529",{"$nulls":9},7,7,7,"39.1","39.1","39.1","18.657",0,"13.927",256380000,12,"0.0788822",1,"0.142334","0.223761","tr|H0Y6Y8|H0Y6Y8_HUMAN;tr|B1AL05|B1AL05_HUMAN;sp|Q8N983|RM43_HUMAN;tr|H0YBU8|H0YBU8_HUMAN;tr|M0R051|M0R051_HUMAN","tr|H0Y6Y8|H0Y6Y8_HUMAN;tr|B1AL05|B1AL05_HUMAN;sp|Q8N983|RM43_HUMAN;tr|H0YBU8|H0YBU8_HUMAN",3436,"H0Y6Y8","H0Y6Y8_HUMAN",null,null,"MRPL43"]
["21.4211","20.047","22.2878","21.4923","20.9797","20.86",{"$nulls":3},"cerebellar granule cell precursor proliferation;proteasome assembly;proteasome core complex assembly","proteasome binding","cytoplasm;cytosol;endoplasmic reticulum;Golgi apparatus;nucleoplasm;nucleus",{"$nulls":3},7,7,7,"32.3","32.3","32.3","32.854",0,"77.121",478430000,30,"0.0728113",1,"0.141322","0.20765","sp|O95456|PSMG1_HUMAN;tr|F8WBH7|F8WBH7_HUMAN","sp|O95456|PSMG1_HUMAN",758,"O95456","PSMG1_HUMAN","Proteasome assembly chaperone 1","AC-1","PSMG1"]
["26.0846","25.2805","25.0042","24.7888","26.3308","24.8306",{"$nulls":3},"ERBB2 signaling pathway;positive regulation of mitophagy in response to mitochondrial depolarization;posttranscriptional regulation of gene expression;protein folding;protein stabilization;protein targeting;regulation of cyclin-dependent protein serine/threonine kinase activity;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway","chaperone binding;heat shock protein binding;Hsp90 protein binding;kinase binding;protein kinase binding;protein kinase regulator activity;protein tyrosine kinase activity;unfolded protein binding","cytoplasm;cytosol;extracellular exosome;HSP90-CDC37 chaperone complex","PI3K-Akt signaling pathway",null,null,13,13,13,"39.9","39.9","39.9","44.468",0,"323.31",7639000000,88,"0.0820627",1,"0.13972","0.23214","sp|Q16543|CDC37_HUMAN;tr|K7EQA9|K7EQA9_HUMAN;tr|K7EKQ2|K7EKQ2_HUMAN;tr|K7EL68|K7EL68_HUMAN;tr|K7EIU0|K7EIU0_HUMAN;tr|K7EJ06|K7EJ06_HUMAN","sp|Q16543|CDC37_HUMAN;tr|K7EQA9|K7EQA9_HUMAN;tr|K7EKQ2|K7EKQ2_HUMAN",2672,"Q16543","CDC37_HUMAN","Hsp90 co-chaperone Cdc37",null,"CDC37"]
[1,"17.9625","19.2887",1,"17.6908","19.1439",{"$nulls":3},"aging;apoptotic process;behavioral fear response;cell migration;cellular response to dexamethasone stimulus;cellular response to growth factor stimulus;cellular response to insulin stimulus;G1/S transition of mitotic cell cycle;germ cell development;long-term memory;negative regulation of apoptotic process;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of insulin receptor signaling pathway;phosphatidylinositol-mediated signaling;positive regulation of mitotic cell cycle;positive regulation of skeletal muscle tissue growth;positive regulation of smooth muscle cell migration;positive regulation of smooth muscle cell proliferation;positive regulation of translation;positive regulation of translational initiation;protein kinase B signaling;regulation of glucose import;response to drug;response to electrical stimulus involved in regulation of muscle adaptation;response to ethanol;response to glucagon;response to glucose;response to heat;response to leucine;response to lipopolysaccharide;response to mechanical stimulus;response to nutrient;response to testosterone;response to toxic substance;response to tumor necrosis factor;response to wounding;signal transduction;skeletal muscle atrophy;skeletal muscle contraction;TOR signaling","ATP binding;identical protein binding;kinase activity;PDZ domain binding;peptide binding;protein kinase activity;protein phosphatase 2A binding;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;ribosomal protein S6 kinase activity","cell junction;cell surface;cytoplasm;cytosol;mitochondrial outer membrane;mitochondrion;neuron projection;nucleoplasm;nucleus;perinuclear region of cytoplasm;synapse","Acute myeloid leukemia;AMPK signaling pathway;Apelin signaling pathway;Autophagy - animal;Breast cancer;Choline metabolism in cancer;Colorectal cancer;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;ErbB signaling pathway;Fc gamma R-mediated phagocytosis;Gastric cancer;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Insulin resistance;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;mTOR signaling pathway;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Proteoglycans in cancer;TGF-beta signaling pathway;Thermogenesis",null,null,3,3,3,"8.6","8.6","8.6","59.139",0,"29.024",96840000,10,"0.00549601",1,"0.138828","0.016768","sp|P23443|KS6B1_HUMAN","sp|P23443|KS6B1_HUMAN",1264,"P23443","KS6B1_HUMAN","Ribosomal protein S6 kinase beta-1","6K1;6K-beta-1","RPS6KB1"]
["19.7198","18.2852","18.2979","19.2369","17.9914","18.6585",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;positive regulation of growth rate;regulation of growth","DBD domain binding;p53 binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;mitochondrion",{"$nulls":3},6,6,6,"25.9","25.9","25.9","37.54",0,"26.454",71908000,16,"0.0821689",1,"0.138706","0.232419","sp|Q8N2F6|ARM10_HUMAN;tr|A0A0J9YWR7|A0A0J9YWR7_HUMAN;tr|H7BXQ8|H7BXQ8_HUMAN;tr|A0A0J9YXE4|A0A0J9YXE4_HUMAN;tr|C9J5N7|C9J5N7_HUMAN;tr|A0A0J9YXV5|A0A0J9YXV5_HUMAN;tr|H7C2M7|H7C2M7_HUMAN;tr|A0A0J9YY38|A0A0J9YY38_HUMAN","sp|Q8N2F6|ARM10_HUMAN;tr|A0A0J9YWR7|A0A0J9YWR7_HUMAN;tr|H7BXQ8|H7BXQ8_HUMAN;tr|A0A0J9YXE4|A0A0J9YXE4_HUMAN;tr|C9J5N7|C9J5N7_HUMAN;tr|A0A0J9YXV5|A0A0J9YXV5_HUMAN;tr|H7C2M7|H7C2M7_HUMAN",3382,"Q8N2F6","ARM10_HUMAN","Armadillo repeat-containing protein 10",null,"ARMC10"]
["16.7673","16.1811","15.7728","17.3985","15.2352","15.6733",{"$nulls":3},"vacuolar transport",null,"integral component of membrane;intracellular",{"$nulls":3},6,2,2,"9.3","2.8","2.8","92.386","0.0021154","3.0275",30271000,1,"0.066815",1,"0.138056","0.19158","tr|E9PSI1|E9PSI1_HUMAN;tr|E9PQI5|E9PQI5_HUMAN;tr|E9PQ80|E9PQ80_HUMAN;tr|H0YI89|H0YI89_HUMAN;tr|E9PJC4|E9PJC4_HUMAN;tr|E9PQY7|E9PQY7_HUMAN;tr|E9PS99|E9PS99_HUMAN;tr|E9PL78|E9PL78_HUMAN;tr|E9PJM1|E9PJM1_HUMAN;tr|E9PMQ9|E9PMQ9_HUMAN;sp|O15321|TM9S1_HUMAN","tr|E9PSI1|E9PSI1_HUMAN;tr|E9PQI5|E9PQI5_HUMAN;tr|E9PQ80|E9PQ80_HUMAN",5524,"E9PSI1","E9PSI1_HUMAN","Transmembrane 9 superfamily member {ECO:0000256|RuleBase:RU363079}"]
["23.4156","22.638","22.485","23.1266","22.1118","22.8886",{"$nulls":3},"muscle contraction","actin binding;calmodulin binding;myosin binding","actin cytoskeleton;intracellular membrane-bounded organelle;plasma membrane",{"$nulls":3},20,20,20,"37.9","37.9","37.9","64.168",0,"133.4",1877800000,99,"0.11883",1,"0.137195","0.326203","tr|E7EX44|E7EX44_HUMAN;tr|E9PGZ1|E9PGZ1_HUMAN;sp|Q05682|CALD1_HUMAN;tr|C9J813|C9J813_HUMAN;tr|C9JEK3|C9JEK3_HUMAN","tr|E7EX44|E7EX44_HUMAN;tr|E9PGZ1|E9PGZ1_HUMAN;sp|Q05682|CALD1_HUMAN;tr|C9J813|C9J813_HUMAN",5509,"E7EX44","E7EX44_HUMAN",null,null,"CALD1"]
["26.8443","25.3712","25.8945","26.5797","25.2911","25.8299",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;response to virus;toxin transport","ATP binding;beta-tubulin binding;G-protein beta-subunit binding;mRNA 3'-UTR binding;mRNA 5'-UTR binding;protein binding involved in protein folding;unfolded protein binding","cell body;centrosome;chaperonin-containing T-complex;cytosol;extracellular exosome;microtubule;myelin sheath;nucleolus;zona pellucida receptor complex",{"$nulls":3},40,40,40,"78.7","78.7","78.7","59.67",0,"323.31",22189000000,497,"0.084711",1,"0.136408","0.239085","sp|P48643|TCPE_HUMAN;tr|B7ZAR1|B7ZAR1_HUMAN;tr|E9PCA1|E9PCA1_HUMAN;tr|E7ENZ3|E7ENZ3_HUMAN;tr|D6RIZ7|D6RIZ7_HUMAN;tr|H0Y914|H0Y914_HUMAN","sp|P48643|TCPE_HUMAN;tr|B7ZAR1|B7ZAR1_HUMAN;tr|E9PCA1|E9PCA1_HUMAN;tr|E7ENZ3|E7ENZ3_HUMAN",1633,"P48643","TCPE_HUMAN","T-complex protein 1 subunit epsilon","CP-1-epsilon","CCT5"]
["19.5691","16.8895","19.2479","19.366","17.1693","18.7672",{"$nulls":3},"proteasomal protein catabolic process;protein arginylation","arginyltransferase activity","cytoplasm;nucleus",{"$nulls":3},6,6,6,"18.9","18.9","18.9","59.09",0,"25.482",131260000,12,"0.0429397",1,"0.134668","0.125937","sp|O95260|ATE1_HUMAN;tr|F5GXE4|F5GXE4_HUMAN;tr|H0Y5C2|H0Y5C2_HUMAN;tr|B4DK25|B4DK25_HUMAN;tr|B4E107|B4E107_HUMAN;tr|Q5SQQ1|Q5SQQ1_HUMAN","sp|O95260|ATE1_HUMAN;tr|F5GXE4|F5GXE4_HUMAN;tr|H0Y5C2|H0Y5C2_HUMAN;tr|B4DK25|B4DK25_HUMAN;tr|B4E107|B4E107_HUMAN;tr|Q5SQQ1|Q5SQQ1_HUMAN",733,"O95260","ATE1_HUMAN","Arginyl-tRNA--protein transferase 1","rginyltransferase 1;-transferase 1","ATE1"]
["25.037","23.7384","24.5877","24.9019","23.5834","24.4764",{"$nulls":3},"10-formyltetrahydrofolate biosynthetic process;embryonic neurocranium morphogenesis;embryonic viscerocranium morphogenesis;folic acid metabolic process;heart development;histidine biosynthetic process;methionine biosynthetic process;methionine metabolic process;neural tube closure;neutrophil homeostasis;one-carbon metabolic process;purine nucleobase biosynthetic process;purine nucleotide biosynthetic process;serine family amino acid biosynthetic process;serine family amino acid metabolic process;somite development;tetrahydrofolate interconversion;transsulfuration","ATP binding;formate-tetrahydrofolate ligase activity;methenyltetrahydrofolate cyclohydrolase activity;methylenetetrahydrofolate dehydrogenase (NAD+) activity;methylenetetrahydrofolate dehydrogenase (NADP+) activity;methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity","cytoplasm;cytosol;extracellular exosome;membrane;mitochondrion","Metabolic pathways;One carbon pool by folate",null,null,49,49,48,"64.7","64.7","63.6","101.56",0,"323.31",11957000000,341,"0.0873577",1,"0.133821","0.245998","sp|P11586|C1TC_HUMAN;tr|F5H2F4|F5H2F4_HUMAN;tr|V9GYY3|V9GYY3_HUMAN;tr|V9GY75|V9GY75_HUMAN","sp|P11586|C1TC_HUMAN;tr|F5H2F4|F5H2F4_HUMAN",1051,"P11586","C1TC_HUMAN","C-1-tetrahydrofolate synthase, cytoplasmic","1-THF synthase","MTHFD1"]
["20.7862","18.8599","18.4767","20.4837","19.2712","17.9688",{"$nulls":3},"cell proliferation;peptidyl-proline hydroxylation;protein hydroxylation;regulation of translational termination;stress granule assembly","iron ion binding;L-ascorbic acid binding;peptidyl-proline 3-dioxygenase activity;peptidyl-proline dioxygenase activity","cytoplasmic stress granule;cytosol;nucleus",{"$nulls":3},7,7,7,"18.6","18.6","18.6","63.245",0,"63.55",166970000,22,"0.0445958",1,"0.133036","0.130581","sp|Q8N543|OGFD1_HUMAN;tr|A0A0A0MTR2|A0A0A0MTR2_HUMAN;tr|H3BR79|H3BR79_HUMAN;tr|H3BUA6|H3BUA6_HUMAN;tr|H3BR02|H3BR02_HUMAN","sp|Q8N543|OGFD1_HUMAN;tr|A0A0A0MTR2|A0A0A0MTR2_HUMAN",3406,"Q8N543","OGFD1_HUMAN","Prolyl 3-hydroxylase OGFOD1",null,"OGFOD1"]
["22.5284","20.9287","21.1608","21.7346","20.9479","21.5415",{"$nulls":3},"cilium assembly;nervous system development;neuron projection development;protein homotrimerization","enzyme binding;identical protein binding","cytoplasm;cytosol;dendrite;extracellular space;membrane;neuronal cell body;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},15,15,15,"39.6","39.6","39.6","53.488",0,"159.03",873710000,63,"0.0841992",1,"0.13132","0.237745","sp|Q9UBB4|ATX10_HUMAN;tr|B1AHE4|B1AHE4_HUMAN;tr|B1AHE3|B1AHE3_HUMAN","sp|Q9UBB4|ATX10_HUMAN",4946,"Q9UBB4","ATX10_HUMAN","Ataxin-10",null,"ATXN10"]
["23.0408","21.3461","22.3918","23.0792","21.0587","22.2487",{"$nulls":3},"cleavage involved in rRNA processing;maturation of LSU-rRNA;mitochondrial translational elongation;mitochondrial translational termination;rRNA pseudouridine synthesis;snRNA pseudouridine synthesis;translation","box H/ACA snoRNA binding;RNA binding;structural constituent of ribosome","box H/ACA snoRNP complex;large ribosomal subunit;mitochondrial inner membrane;mitochondrion","Ribosome",null,null,11,11,11,"40.6","40.6","40.6","36.908",0,"113.22",887990000,50,"0.0590471",1,"0.130701","0.170523","sp|Q9BYD6|RM01_HUMAN;tr|H0Y8N7|H0Y8N7_HUMAN","sp|Q9BYD6|RM01_HUMAN;tr|H0Y8N7|H0Y8N7_HUMAN",4313,"Q9BYD6","RM01_HUMAN","39S ribosomal protein L1, mitochondrial","1mt;RP-L1","MRPL1"]
["17.6224","18.7852",1,"17.5707","18.4535",1,{"$nulls":3},"intrinsic apoptotic signaling pathway by p53 class mediator;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;nucleotide metabolic process;purine nucleotide metabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated","bis(5'-adenosyl)-triphosphatase activity;catalytic activity;hydrolase activity;identical protein binding;nucleotide binding;ubiquitin protein ligase binding","cytoplasm;cytosol;extracellular exosome;fibrillar center;mitochondrion;plasma membrane","Metabolic pathways;Non-small cell lung cancer;Purine metabolism;Small cell lung cancer",null,null,3,3,3,"20.4","20.4","20.4","16.858",0,"6.0369",20623000,2,"0.00518565",1,"0.127815","0.0158267","sp|P49789|FHIT_HUMAN;tr|E9PBZ0|E9PBZ0_HUMAN","sp|P49789|FHIT_HUMAN",1683,"P49789","FHIT_HUMAN","Bis(5'-adenosyl)-triphosphatase",null,"FHIT"]
["22.8387","21.7545","21.2941","23.0846","21.2718","21.1514",{"$nulls":3},"cell differentiation;nervous system development",null,"cytoplasm;cytosol;microtubule;microtubule cytoskeleton",{"$nulls":3},12,12,12,"56.6","56.6","56.6","27.325",0,"108.04",923120000,58,"0.056366",1,"0.126472","0.16319","sp|Q99426|TBCB_HUMAN;tr|K7EP07|K7EP07_HUMAN;tr|K7EK42|K7EK42_HUMAN;tr|K7EL99|K7EL99_HUMAN;tr|K7EQH0|K7EQH0_HUMAN;tr|K7ER04|K7ER04_HUMAN","sp|Q99426|TBCB_HUMAN;tr|K7EP07|K7EP07_HUMAN;tr|K7EK42|K7EK42_HUMAN",4058,"Q99426","TBCB_HUMAN","Tubulin-folding cofactor B",null,"TBCB"]
["21.0233","20.097","20.3945","21.5214","20.0185","19.5967",{"$nulls":3},"early endosome to late endosome transport;endocytic recycling;endosomal transport;macroautophagy;multivesicular body assembly;multivesicular body sorting pathway;positive regulation of exosomal secretion;positive regulation of gene expression;positive regulation of protein catabolic process;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;regulation of multivesicular body size involved in endosome transport;regulation of protein catabolic process;regulation of protein complex stability;regulation of transcription from RNA polymerase II promoter;regulation of viral budding via host ESCRT complex;transcription, DNA-templated","channel regulator activity;protein C-terminus binding;protein homodimerization activity;protein N-terminus binding;transcription factor binding","cytoplasm;cytosol;endosome membrane;ESCRT II complex;extracellular exosome;late endosome membrane;membrane;nucleoplasm;nucleus;perinuclear region of cytoplasm;plasma membrane;recycling endosome;transcription factor complex","Endocytosis",null,null,3,3,3,"13.6","13.6","13.6","28.864",0,"16.122",125310000,10,"0.0682616",1,"0.126034","0.195471","sp|Q96H20|SNF8_HUMAN;tr|H0Y8S5|H0Y8S5_HUMAN;tr|D6RBI1|D6RBI1_HUMAN;tr|D6RJ86|D6RJ86_HUMAN;tr|D6RFY6|D6RFY6_HUMAN","sp|Q96H20|SNF8_HUMAN;tr|H0Y8S5|H0Y8S5_HUMAN;tr|D6RBI1|D6RBI1_HUMAN;tr|D6RJ86|D6RJ86_HUMAN;tr|D6RFY6|D6RFY6_HUMAN",3905,"Q96H20","SNF8_HUMAN","Vacuolar-sorting protein SNF8",null,"SNF8"]
["24.5037","22.9744","23.6303","24.2064","22.3672","24.1593",{"$nulls":3},"negative regulation of translational elongation;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane, translocation","7S RNA binding;RNA binding;signal recognition particle binding","cytosol;extracellular exosome;signal recognition particle receptor complex;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,6,6,6,"61.6","61.6","61.6","10.112",0,"71.153",2571800000,100,"0.0577175",1,"0.125186","0.166891","sp|P49458|SRP09_HUMAN;tr|E9PE20|E9PE20_HUMAN","sp|P49458|SRP09_HUMAN;tr|E9PE20|E9PE20_HUMAN",1662,"P49458","SRP09_HUMAN","Signal recognition particle 9 kDa protein","RP9","SRP9"]
["15.3551","15.1092",1,"15.5224","14.572",1,{"$nulls":4},"nucleic acid binding;zinc ion binding","nucleoplasm;plasma membrane",{"$nulls":3},2,2,2,"3.8","3.8","3.8","91.124","0.00041885","4.4156",7170200,2,"0.00606256",1,"0.123324","0.0184847","tr|H0Y5D5|H0Y5D5_HUMAN;tr|Q9BTG3|Q9BTG3_HUMAN;tr|Q5SYW2|Q5SYW2_HUMAN;sp|Q9ULV3|CIZ1_HUMAN;tr|F5H2X7|F5H2X7_HUMAN","tr|H0Y5D5|H0Y5D5_HUMAN;tr|Q9BTG3|Q9BTG3_HUMAN;tr|Q5SYW2|Q5SYW2_HUMAN;sp|Q9ULV3|CIZ1_HUMAN;tr|F5H2X7|F5H2X7_HUMAN",5133,"H0Y5D5","H0Y5D5_HUMAN",null,null,"CIZ1"]
["24.4889","23.2247","23.4644","24.277","22.8506","23.6844",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding",{"$nulls":4},32,32,24,"55.2","55.2","41.4","69.086",0,"323.31",5029800000,231,"0.0756334",1,"0.121991","0.215158","tr|J3KTA4|J3KTA4_HUMAN;sp|P17844|DDX5_HUMAN;tr|J3QRQ7|J3QRQ7_HUMAN;tr|J3KRZ1|J3KRZ1_HUMAN;tr|J3QSF1|J3QSF1_HUMAN;tr|J3KRX8|J3KRX8_HUMAN;tr|J3QR02|J3QR02_HUMAN;tr|X6RLV5|X6RLV5_HUMAN;tr|J3QRN5|J3QRN5_HUMAN;tr|J3QLG9|J3QLG9_HUMAN;tr|J3QR62|J3QR62_HUMAN","tr|J3KTA4|J3KTA4_HUMAN;sp|P17844|DDX5_HUMAN",1164,"J3KTA4","J3KTA4_HUMAN",null,null,"DDX5"]
["21.5098","19.6646","21.0459","21.0251","19.805","21.0286",{"$nulls":3},"acute-phase response;aging;astrocyte differentiation;cell proliferation;cellular response to hormone stimulus;cellular response to leptin stimulus;cellular response to organic cyclic compound;cytokine-mediated signaling pathway;eating behavior;energy homeostasis;eye photoreceptor cell differentiation;glucose homeostasis;growth hormone receptor signaling pathway;inflammatory response;interleukin-12-mediated signaling pathway;interleukin-15-mediated signaling pathway;interleukin-6-mediated signaling pathway;interleukin-7-mediated signaling pathway;intracellular receptor signaling pathway;JAK-STAT cascade;JAK-STAT cascade involved in growth hormone signaling pathway;leptin-mediated signaling pathway;miRNA mediated inhibition of translation;movement of cell or subcellular component;mRNA transcription from RNA polymerase II promoter;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of glycolytic process;negative regulation of hydrogen peroxide biosynthetic process;negative regulation of neuron death;negative regulation of neuron migration;negative regulation of stem cell differentiation;negative regulation of transcription from RNA polymerase II promoter;nervous system development;phosphorylation;positive regulation of angiogenesis;positive regulation of ATP biosynthetic process;positive regulation of erythrocyte differentiation;positive regulation of gene expression;positive regulation of gene silencing by miRNA;positive regulation of growth factor dependent skeletal muscle satellite cell proliferation;positive regulation of metalloendopeptidase activity;positive regulation of Notch signaling pathway;positive regulation of pri-miRNA transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of tyrosine phosphorylation of STAT protein;positive regulation of vascular endothelial cell proliferation;protein import into nucleus;radial glial cell differentiation;regulation of cell cycle;regulation of feeding behavior;regulation of mitochondrial membrane permeability;regulation of multicellular organism growth;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;response to drug;response to estradiol;response to ethanol;response to leptin;sexual reproduction;signal transduction;somatic stem cell population maintenance;temperature homeostasis;T-helper 17 cell lineage commitment;viral process","CCR5 chemokine receptor binding;chromatin DNA binding;DNA binding;DNA binding transcription factor activity;glucocorticoid receptor binding;identical protein binding;nuclear receptor activity;protein dimerization activity;protein homodimerization activity;protein kinase binding;protein phosphatase binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II repressing transcription factor binding;signal transducer activity;transcription factor binding;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytoplasm;cytosol;mitochondrial inner membrane;nuclear chromatin;nucleoplasm;nucleus;plasma membrane;RNA polymerase II transcription factor complex","Acute myeloid leukemia;Adipocytokine signaling pathway;AGE-RAGE signaling pathway in diabetic complications;Chemokine signaling pathway;EGFR tyrosine kinase inhibitor resistance;Epstein-Barr virus infection;FoxO signaling pathway;Hepatitis B;Hepatitis C;HIF-1 signaling pathway;Human cytomegalovirus infection;Inflammatory bowel disease (IBD);Insulin resistance;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Measles;MicroRNAs in cancer;Necroptosis;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Prolactin signaling pathway;Proteoglycans in cancer;Signaling pathways regulating pluripotency of stem cells;Th17 cell differentiation;Toxoplasmosis;Viral carcinogenesis",null,null,23,23,23,"40.9","40.9","40.9","88.067",0,"153.62",764520000,72,"0.0608008",1,"0.120563","0.175301","sp|P40763|STAT3_HUMAN;tr|G8JLH9|G8JLH9_HUMAN;tr|K7EP08|K7EP08_HUMAN","sp|P40763|STAT3_HUMAN;tr|G8JLH9|G8JLH9_HUMAN",1521,"P40763","STAT3_HUMAN","Signal transducer and activator of transcription 3 {ECO:0000312|HGNC:HGNC:11364}",null,"STAT3"]
["22.9937","21.8825","22.3366","22.7977","21.5861","22.4716",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;response to alkaloid;response to toxic substance;RNA splicing","ATP binding;ATP-dependent RNA helicase activity;double-stranded RNA binding;RNA binding;RNA helicase activity","cytoplasm;nuclear speck;nucleolus;nucleoplasm;nucleus;U12-type spliceosomal complex","Spliceosome",null,null,31,31,31,"42.8","42.8","42.8","90.932",0,"141.1",2637900000,228,"0.087234",1,"0.119112","0.245676","sp|O43143|DHX15_HUMAN","sp|O43143|DHX15_HUMAN",387,"O43143","DHX15_HUMAN","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15",null,"DHX15"]
["19.6253","18.2769","18.9788","19.4146","18.1658","18.9436",{"$nulls":3},"negative regulation of telomere maintenance via telomerase;rRNA acetylation involved in maturation of SSU-rRNA;rRNA modification;tRNA acetylation;tRNA wobble cytosine modification","ATP binding;DNA polymerase binding;N-acetyltransferase activity;RNA binding;rRNA cytidine N-acetyltransferase activity;tRNA binding;tRNA N-acetyltransferase activity","90S preribosome;membrane;midbody;nuclear chromosome, telomeric region;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes",null,null,32,32,32,"41.1","41.1","41.1","115.73",0,"323.31",3631900000,232,"0.0786936",1,"0.119017","0.223262","sp|Q9H0A0|NAT10_HUMAN;tr|A0A087WV29|A0A087WV29_HUMAN;tr|E9PMU0|E9PMU0_HUMAN;tr|E9PJN6|E9PJN6_HUMAN","sp|Q9H0A0|NAT10_HUMAN;tr|A0A087WV29|A0A087WV29_HUMAN",4382,"Q9H0A0","NAT10_HUMAN","RNA cytidine acetyltransferase {ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000305}",null,"NAT10"]
["22.2219","20.6717","21.0026","22.2499","20.3968","20.8959",{"$nulls":3},"cellular response to retinoic acid;generation of catalytic spliceosome for second transesterification step;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;mRNA splicing, via spliceosome;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;Notch signaling pathway;positive regulation by host of viral transcription;positive regulation of histone H3-K4 methylation;positive regulation of mRNA splicing, via spliceosome;positive regulation of neurogenesis;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transforming growth factor beta receptor signaling pathway;positive regulation of vitamin D receptor signaling pathway;regulation of retinoic acid receptor signaling pathway;regulation of transcription from RNA polymerase II promoter;regulation of vitamin D receptor signaling pathway;retinoic acid receptor signaling pathway;transcription initiation from RNA polymerase II promoter;viral process","androgen receptor binding;enzyme binding;Notch binding;nuclear hormone receptor binding;retinoic acid receptor binding;RNA binding;SMAD binding;transcription coactivator activity;transcription corepressor activity;vitamin D receptor binding","catalytic step 2 spliceosome;nuclear body;nuclear matrix;nuclear speck;nucleoplasm;nucleus;post-mRNA release spliceosomal complex;spliceosomal complex","Epstein-Barr virus infection;Notch signaling pathway;Spliceosome;Viral carcinogenesis",null,null,19,19,19,"43.1","43.1","43.1","61.494",0,"172.74",1796400000,138,"0.0559811",1,"0.117885","0.162134","sp|Q13573|SNW1_HUMAN;tr|G3V3A4|G3V3A4_HUMAN;tr|G3V4X8|G3V4X8_HUMAN;tr|G3V5R3|G3V5R3_HUMAN","sp|Q13573|SNW1_HUMAN;tr|G3V3A4|G3V3A4_HUMAN;tr|G3V4X8|G3V4X8_HUMAN",2384,"Q13573","SNW1_HUMAN","SNW domain-containing protein 1",null,"SNW1"]
["16.9911","17.9878","16.7751","17.3094","18.2455","15.8491",{"$nulls":3},"actin cytoskeleton organization;intracellular signal transduction","ATP binding;metal ion binding;protein serine/threonine kinase activity","intracellular",{"$nulls":3},41,41,19,"30.5","30.5","14.6","193.63",0,"196.2",1137200000,121,"0.0506783",1,"0.116687","0.147518","tr|A0A0A0MRJ0|A0A0A0MRJ0_HUMAN;sp|Q5VT25|MRCKA_HUMAN;tr|H0Y7V8|H0Y7V8_HUMAN;tr|H0Y6R0|H0Y6R0_HUMAN","tr|A0A0A0MRJ0|A0A0A0MRJ0_HUMAN;sp|Q5VT25|MRCKA_HUMAN",2897,"A0A0A0MRJ0","A0A0A0MRJ0_HUMAN",null,null,"CDC42BPA"]
["21.15","20.5257","20.8362","21.1703","20.2367","20.7591",{"$nulls":3},"animal organ morphogenesis;blood coagulation;cell adhesion;cell adhesion mediated by integrin;cell proliferation;cell-matrix adhesion;cell-substrate adhesion;cellular response to estradiol stimulus;cellular response to mechanical stimulus;collagen-activated signaling pathway;detection of mechanical stimulus involved in sensory perception of pain;establishment of protein localization;extracellular matrix organization;female pregnancy;focal adhesion assembly;hepatocyte differentiation;hypotonic response;integrin-mediated signaling pathway;mammary gland development;mesodermal cell differentiation;positive regulation of alkaline phosphatase activity;positive regulation of cell adhesion;positive regulation of cell projection organization;positive regulation of collagen binding;positive regulation of collagen biosynthetic process;positive regulation of DNA binding;positive regulation of epithelial cell migration;positive regulation of inflammatory response;positive regulation of leukocyte migration;positive regulation of phagocytosis, engulfment;positive regulation of positive chemotaxis;positive regulation of smooth muscle cell migration;positive regulation of smooth muscle cell proliferation;positive regulation of smooth muscle contraction;positive regulation of translation;positive regulation of transmission of nerve impulse;response to amine;response to drug;response to hypoxia;response to L-ascorbic acid;response to muscle activity;response to parathyroid hormone;skin morphogenesis;substrate-dependent cell migration","amyloid-beta binding;collagen binding;collagen binding involved in cell-matrix adhesion;collagen receptor activity;heparan sulfate proteoglycan binding;integrin binding;laminin binding;metal ion binding;protein complex binding;protein heterodimerization activity;virus receptor activity","axon;axon terminus;basal part of cell;cell surface;external side of plasma membrane;focal adhesion;integrin alpha2-beta1 complex;integrin complex;nucleus;perinuclear region of cytoplasm;plasma membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Hematopoietic cell lineage;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);Pathways in cancer;Phagosome;PI3K-Akt signaling pathway;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Small cell lung cancer",null,null,21,21,4,"23.5","23.5","4.3","129.29",0,"107.45",922810000,77,"0.130481",1,"0.115299","0.355039","sp|P17301|ITA2_HUMAN","sp|P17301|ITA2_HUMAN",1153,"P17301","ITA2_HUMAN","Integrin alpha-2",null,"ITGA2"]
["24.2399","22.1034","23.6744","23.9621","22.3426","23.368",{"$nulls":3},"cell cycle arrest;peptidyl-threonine dephosphorylation;protein dephosphorylation","metal ion binding;protein serine/threonine phosphatase activity","cytoplasm;membrane;nucleoplasm;nucleus",{"$nulls":3},17,17,17,"45.8","45.8","45.8","59.271",0,"323.31",2849000000,146,"0.0496571",1,"0.115044","0.144688","sp|O15355|PPM1G_HUMAN","sp|O15355|PPM1G_HUMAN",367,"O15355","PPM1G_HUMAN","Protein phosphatase 1G",null,"PPM1G"]
["25.7012","24.7812","25.2576","25.9391","24.3535","25.1067",{"$nulls":3},"adult locomotory behavior;negative regulation of peptidase activity;negative regulation of proteolysis;neutrophil degranulation","cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;protease binding;RNA binding","cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;nucleolus;secretory granule lumen;tertiary granule lumen",{"$nulls":3},6,6,6,"70.4","70.4","70.4","11.139",0,"150.26",2079400000,62,"0.0754107",1,"0.113592","0.214567","sp|P04080|CYTB_HUMAN","sp|P04080|CYTB_HUMAN",865,"P04080","CYTB_HUMAN","Cystatin-B",null,"CSTB"]
["26.8605","25.4027","26.6517","26.7357","25.4096","26.4296",{"$nulls":3},"actin filament organization;antigen processing and presentation of exogenous peptide antigen via MHC class II;cellular copper ion homeostasis;cellular response to virus;dendritic spine organization;Golgi to transport vesicle transport;interleukin-12-mediated signaling pathway;long term synaptic depression;lysosomal membrane organization;mitotic cleavage furrow ingression;phosphatidylinositol biosynthetic process;positive regulation of calcium ion-dependent exocytosis;positive regulation of dendritic spine development;positive regulation of endocytosis;positive regulation of ER to Golgi vesicle-mediated transport;positive regulation of late endosome to lysosome transport;positive regulation of protein secretion;positive regulation of sodium ion transmembrane transport;post-Golgi vesicle-mediated transport;protein transport;regulation of Arp2/3 complex-mediated actin nucleation;regulation of defense response to virus by virus;regulation of phospholipid metabolic process;regulation of receptor internalization;small GTPase mediated signal transduction;synaptic vesicle budding;very-low-density lipoprotein particle assembly","GDP binding;GTP binding;GTPase activity;magnesium ion binding;phospholipase D activator activity;protein domain specific binding;protein heterodimerization activity;RNA binding;signal transducer activity, downstream of receptor","cell leading edge;COPI-coated vesicle;cytosol;extracellular exosome;focal adhesion;Golgi membrane;late endosome;neuron projection;perinuclear region of cytoplasm;peroxisomal membrane;plasma membrane;postsynaptic density;postsynaptic membrane;protein complex;sarcomere;trans-Golgi network","Endocytosis;Legionellosis;Phospholipase D signaling pathway;Vibrio cholerae infection",null,null,12,12,8,84,84,"55.2","20.697",0,"199.51",9258300000,198,"0.0650825",1,"0.113361","0.186908","sp|P84077|ARF1_HUMAN;sp|P61204|ARF3_HUMAN;tr|F5H423|F5H423_HUMAN;tr|F5H0C7|F5H0C7_HUMAN;tr|H0YGG7|H0YGG7_HUMAN","sp|P84077|ARF1_HUMAN;sp|P61204|ARF3_HUMAN;tr|F5H423|F5H423_HUMAN",2095,"P84077","ARF1_HUMAN","ADP-ribosylation factor 1",null,"ARF1"]
["18.3904","17.9204","18.9002","19.0526","17.4304","18.3924",{"$nulls":3},"DNA repair","DNA binding;DNA-directed DNA polymerase activity","nucleus",{"$nulls":3},5,5,2,30,30,"15.6","27.203",0,"38.379",101080000,8,"0.07132",1,"0.111904","0.203668","tr|H0YBJ0|H0YBJ0_HUMAN;sp|P06746|DPOLB_HUMAN;tr|E5RIJ0|E5RIJ0_HUMAN;tr|E5RHZ4|E5RHZ4_HUMAN","tr|H0YBJ0|H0YBJ0_HUMAN;sp|P06746|DPOLB_HUMAN;tr|E5RIJ0|E5RIJ0_HUMAN",921,"H0YBJ0","H0YBJ0_HUMAN",null,null,"POLB"]
["18.5613","16.6607","17.0673","18.0818","15.8337","18.0407",{"$nulls":5},"nucleolus",{"$nulls":3},7,7,7,"34.7","34.7","34.7","27.091",0,"38.187",209970000,28,"0.0401159",1,"0.111015","0.117984","tr|E7ENR5|E7ENR5_HUMAN;tr|H0Y714|H0Y714_HUMAN;sp|Q96G21|IMP4_HUMAN;tr|B9A008|B9A008_HUMAN;tr|B8ZZ47|B8ZZ47_HUMAN","tr|E7ENR5|E7ENR5_HUMAN;tr|H0Y714|H0Y714_HUMAN;sp|Q96G21|IMP4_HUMAN;tr|B9A008|B9A008_HUMAN;tr|B8ZZ47|B8ZZ47_HUMAN",3885,"E7ENR5","E7ENR5_HUMAN",null,null,"IMP4"]
["23.0664","21.468","22.186","22.7877","21.3049","22.2987",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell division;ciliary basal body-plasma membrane docking;cytoplasmic microtubule organization;cytoplasmic mRNA processing body assembly;ER to Golgi vesicle-mediated transport;establishment of spindle localization;G2/M transition of mitotic cell cycle;minus-end-directed vesicle transport along microtubule;mitotic spindle organization;neutrophil degranulation;positive regulation of intracellular transport;positive regulation of spindle assembly;regulation of G2/M transition of mitotic cell cycle;regulation of metaphase plate congression;regulation of mitotic spindle organization;sister chromatid cohesion;stress granule assembly","ATP binding;ATPase activity;dynein intermediate chain binding;dynein light chain binding;dynein light intermediate chain binding;microtubule motor activity;RNA binding","azurophil granule lumen;centrosome;cytoplasmic dynein complex;cytosol;extracellular exosome;extracellular matrix;extracellular region;filopodium;membrane;microtubule","Phagosome;Salmonella infection;Vasopressin-regulated water reabsorption",null,null,184,184,184,"48.8","48.8","48.8","532.4",0,"323.31",13450000000,824,"0.0597959",1,"0.109677","0.172565","sp|Q14204|DYHC1_HUMAN;tr|H0YJ21|H0YJ21_HUMAN","sp|Q14204|DYHC1_HUMAN",2456,"Q14204","DYHC1_HUMAN","Cytoplasmic dynein 1 heavy chain 1",null,"DYNC1H1"]
["24.0256","21.0061","23.5151","24.0948","20.8451","23.2816",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;barbed-end actin filament capping;blood coagulation;ER to Golgi vesicle-mediated transport;innate immune response;movement of cell or subcellular component;protein complex assembly","actin binding","actin cytoskeleton;brush border;cortical cytoskeleton;cytosol;extracellular exosome;extracellular region;F-actin capping protein complex;membrane","Endocytosis",null,null,10,8,8,"59.8","50.3","50.3","32.949",0,"223.2",1239200000,74,"0.0269377",1,"0.108445","0.080297","sp|P47755|CAZA2_HUMAN;tr|C9JUG7|C9JUG7_HUMAN;tr|F8W9N7|F8W9N7_HUMAN;tr|A0A0D9SET8|A0A0D9SET8_HUMAN;tr|F8WED3|F8WED3_HUMAN","sp|P47755|CAZA2_HUMAN;tr|C9JUG7|C9JUG7_HUMAN;tr|F8W9N7|F8W9N7_HUMAN;tr|A0A0D9SET8|A0A0D9SET8_HUMAN",1612,"P47755","CAZA2_HUMAN","F-actin-capping protein subunit alpha-2",null,"CAPZA2"]
["23.2956","21.8207","22.861","23.1024","21.798","22.7539",{"$nulls":4},"ATP binding","cytosol",{"$nulls":3},38,38,37,"55.2","55.2","54.3","82.091",0,"323.31",3435000000,185,"0.0638883",1,"0.107652","0.183679","tr|I3L0N3|I3L0N3_HUMAN;sp|P46459|NSF_HUMAN;tr|I3L0L3|I3L0L3_HUMAN;tr|I3L2G1|I3L2G1_HUMAN;tr|K7EQD6|K7EQD6_HUMAN;tr|I3L338|I3L338_HUMAN;tr|I3L4Q9|I3L4Q9_HUMAN","tr|I3L0N3|I3L0N3_HUMAN;sp|P46459|NSF_HUMAN",1592,"I3L0N3","I3L0N3_HUMAN",null,null,"NSF"]
["22.0261","20.9423","22.0687","21.8631","20.9065","21.9472",{"$nulls":3},"canonical glycolysis;carbohydrate phosphorylation;cellular glucose homeostasis;establishment of protein localization to mitochondrion;glycolytic process;maintenance of protein location in mitochondrion;positive regulation of cytokine secretion involved in immune response;positive regulation of interleukin-1 beta secretion","ATP binding;fructokinase activity;glucokinase activity;glucose binding;hexokinase activity;mannokinase activity;peptidoglycan binding","cytosol;membrane raft;mitochondrial outer membrane;mitochondrion;sperm principal piece","Amino sugar and nucleotide sugar metabolism;Carbohydrate digestion and absorption;Carbon metabolism;Central carbon metabolism in cancer;Fructose and mannose metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Insulin signaling pathway;Metabolic pathways;Neomycin, kanamycin and gentamicin biosynthesis;Starch and sucrose metabolism;Type II diabetes mellitus",null,null,33,33,29,"38.3","38.3","34.1","102.48",0,"206.86",1810600000,139,"0.075462",1,"0.106761","0.214703","sp|P19367|HXK1_HUMAN;tr|B1AR63|B1AR63_HUMAN;tr|B1AR62|B1AR62_HUMAN;tr|B1AR61|B1AR61_HUMAN;sp|Q2TB90|HKDC1_HUMAN","sp|P19367|HXK1_HUMAN",1190,"P19367","HXK1_HUMAN","Hexokinase-1",null,"HK1"]
["22.9219","22.2882","22.7882","23.4458","21.5732","22.6669",{"$nulls":4},"ATP binding",{"$nulls":4},1,1,1,"9.4","9.4","9.4","13.999","0.00061475","3.9709",535200000,7,"0.0627466",1,"0.104078","0.180586","tr|K7EM02|K7EM02_HUMAN;tr|K7EIJ8|K7EIJ8_HUMAN;sp|Q8IYT4|KATL2_HUMAN","tr|K7EM02|K7EM02_HUMAN;tr|K7EIJ8|K7EIJ8_HUMAN;sp|Q8IYT4|KATL2_HUMAN",3346,"K7EM02","K7EM02_HUMAN",null,null,"KATNAL2"]
["20.5928","18.866","20.0829","20.4126","18.6664","20.1508",{"$nulls":3},"cell proliferation;cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);regulation of cell cycle;regulation of signal transduction by p53 class mediator;ribosomal large subunit assembly;ribosome biogenesis;rRNA processing","ribonucleoprotein complex binding;RNA binding","intracellular ribonucleoprotein complex;nucleolus;nucleoplasm;nucleus;PeBoW complex;preribosome, large subunit precursor",{"$nulls":3},30,30,30,"49.5","49.5","49.5","83.629",0,"323.31",2834600000,175,"0.0476758",1,"0.103966","0.139181","sp|Q14137|BOP1_HUMAN;tr|A0A075B729|A0A075B729_HUMAN","sp|Q14137|BOP1_HUMAN",2436,"Q14137","BOP1_HUMAN","Ribosome biogenesis protein BOP1 {ECO:0000255|HAMAP-Rule:MF_03027}",null,"BOP1"]
["23.5497","21.943","22.9972","23.2605","21.94","22.9809",{"$nulls":3},"DNA packaging;internal protein amino acid acetylation;negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric;N-terminal peptidyl-glutamic acid acetylation;N-terminal peptidyl-serine acetylation;N-terminal protein amino acid acetylation;protein acetylation","N-acetyltransferase activity;peptide alpha-N-acetyltransferase activity;peptide-glutamate-N-acetyltransferase activity;peptide-serine-N-acetyltransferase activity","cytoplasm;cytosol;cytosolic ribosome;intracellular;membrane;NatA complex;nucleolus;nucleus",{"$nulls":3},10,10,10,"47.2","47.2","47.2","26.458",0,"77.749",1137200000,68,"0.0574016",1,"0.102819","0.166026","sp|P41227|NAA10_HUMAN;tr|F8W808|F8W808_HUMAN;tr|A8MWP7|A8MWP7_HUMAN;tr|C9JN83|C9JN83_HUMAN;tr|C9JW55|C9JW55_HUMAN;sp|Q9BSU3|NAA11_HUMAN;tr|H0Y8T0|H0Y8T0_HUMAN","sp|P41227|NAA10_HUMAN;tr|F8W808|F8W808_HUMAN;tr|A8MWP7|A8MWP7_HUMAN;tr|C9JN83|C9JN83_HUMAN",1533,"P41227","NAA10_HUMAN","N-alpha-acetyltransferase 10",null,"NAA10"]
["16.5186","16.7279","16.5555","16.5799","16.2256","16.6885",{"$nulls":3},"chaperone-mediated protein folding;'de novo' protein folding;plus-end-directed vesicle transport along microtubule;positive regulation of autophagosome maturation","ATP binding;metal ion binding;protein binding involved in protein folding;unfolded protein binding","autophagosome;Golgi apparatus;intracellular membrane-bounded organelle;late endosome;lysosome;membrane",{"$nulls":3},7,7,7,"6.6","6.6","6.6","166.98",0,"45.366",100340000,11,"0.266527",1,"0.10266","0.666885","sp|Q9BQS8|FYCO1_HUMAN","sp|Q9BQS8|FYCO1_HUMAN",4154,"Q9BQS8","FYCO1_HUMAN","FYVE and coiled-coil domain-containing protein 1",null,"FYCO1"]
["22.0293","20.8617","19.4134","21.2338","19.9033","20.8603",{"$nulls":3},"transcription initiation from RNA polymerase II promoter",null,"extracellular exosome;nucleoplasm",{"$nulls":3},4,4,4,"45.3","45.3","45.3","15.876",0,"27.958",132800000,14,"0.0407532",1,"0.102301","0.119783","sp|Q86WQ0|NR2CA_HUMAN;tr|U3KQ53|U3KQ53_HUMAN;tr|F5H0B6|F5H0B6_HUMAN","sp|Q86WQ0|NR2CA_HUMAN;tr|U3KQ53|U3KQ53_HUMAN",3245,"Q86WQ0","NR2CA_HUMAN","Nuclear receptor 2C2-associated protein",null,"NR2C2AP"]
["23.1736","22.116","23.0327","23.2254","21.9076","22.8885",{"$nulls":3},"early endosome to Golgi transport;endocytosis;intracellular protein transport;lamellipodium morphogenesis;protein oligomerization;retrograde transport, endosome to Golgi;vesicle organization","cadherin binding;epidermal growth factor receptor binding;insulin receptor binding;leptin receptor binding;phosphatidylinositol binding;protein heterodimerization activity;protein homodimerization activity;transferrin receptor binding","cytoplasm;cytosol;early endosome membrane;endosome;endosome membrane;extracellular exosome;extrinsic component of membrane;lamellipodium;lysosome;membrane;protein complex;retromer complex;retromer, tubulation complex","Endocytosis",null,null,18,18,16,"36.6","36.6","32.6","58.47",0,"121.05",1973800000,108,"0.0678446",1,"0.100265","0.194351","sp|O60749|SNX2_HUMAN;tr|D6RC15|D6RC15_HUMAN","sp|O60749|SNX2_HUMAN",520,"O60749","SNX2_HUMAN","Sorting nexin-2",null,"SNX2"]
["29.568","28.1813","28.9073","29.2997","28.0949","28.9654",{"$nulls":3},"actin cytoskeleton organization;negative regulation of actin filament bundle assembly;negative regulation of actin filament polymerization;negative regulation of stress fiber assembly;neural tube closure;positive regulation of actin filament bundle assembly;positive regulation of actin filament polymerization;positive regulation of ATPase activity;positive regulation of epithelial cell migration;positive regulation of ruffle assembly;protein stabilization;regulation of transcription from RNA polymerase II promoter;Wnt signaling pathway, planar cell polarity pathway","actin binding;actin monomer binding;adenyl-nucleotide exchange factor activity;cadherin binding;phosphatidylinositol-4,5-bisphosphate binding;proline-rich region binding;Rho GTPase binding;RNA binding","blood microparticle;cell cortex;cytoplasm;cytoskeleton;cytosol;extracellular exosome;focal adhesion;membrane;nucleus","Rap1 signaling pathway;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,12,12,12,"92.9","92.9","92.9","15.054",0,"323.31",44933000000,479,"0.0639338",1,"0.0988642","0.183802","sp|P07737|PROF1_HUMAN;tr|K7EJ44|K7EJ44_HUMAN;CON__P02584;tr|I3L3D5|I3L3D5_HUMAN","sp|P07737|PROF1_HUMAN;tr|K7EJ44|K7EJ44_HUMAN",941,"P07737","PROF1_HUMAN","Profilin-1",null,"PFN1"]
["20.3615","17.3497",1,"20.2614","17.1538",1,{"$nulls":3},"cell differentiation;spermatogenesis","metal ion binding","cytoplasm",{"$nulls":3},3,3,3,"31.7","31.7","31.7","19.266",0,"11.185",41465000,5,"0.00380765",1,"0.0986417","0.0116392","sp|Q8WW33|GTSF1_HUMAN;tr|G3V1V4|G3V1V4_HUMAN","sp|Q8WW33|GTSF1_HUMAN;tr|G3V1V4|G3V1V4_HUMAN",3631,"Q8WW33","GTSF1_HUMAN","Gametocyte-specific factor 1",null,"GTSF1"]
["19.599","19.3526","19.4779","20.1245","18.7223","19.2928",{"$nulls":3},"cell-matrix adhesion;glutamate secretion;negative regulation of protein localization to plasma membrane;negative regulation of stress fiber assembly;neurotransmitter secretion;signal transduction","signal transducer activity","cytoplasm;cytosol;focal adhesion;presynaptic active zone",{"$nulls":3},26,26,24,"30.2","30.2","27.7","135.78",0,"309.13",1522600000,147,"0.0826812",1,"0.0966123","0.233764","sp|Q13136|LIPA1_HUMAN;tr|E9PJZ7|E9PJZ7_HUMAN;tr|H0YEF9|H0YEF9_HUMAN;tr|H0YDW2|H0YDW2_HUMAN;tr|E9PPF6|E9PPF6_HUMAN;tr|H0YD72|H0YD72_HUMAN;tr|E9PID5|E9PID5_HUMAN;tr|H0YHK3|H0YHK3_HUMAN;tr|G3V200|G3V200_HUMAN;sp|O75334|LIPA2_HUMAN;tr|H0YF15|H0YF15_HUMAN;tr|R4GNF1|R4GNF1_HUMAN;tr|H0YIJ4|H0YIJ4_HUMAN;tr|H0YHJ4|H0YHJ4_HUMAN;tr|H0YH95|H0YH95_HUMAN;tr|R4GN36|R4GN36_HUMAN;sp|O75145|LIPA3_HUMAN","sp|Q13136|LIPA1_HUMAN;tr|E9PJZ7|E9PJZ7_HUMAN",2311,"Q13136","LIPA1_HUMAN","Liprin-alpha-1",null,"PPFIA1"]
["17.3546",1,"18.4316","17.2916",1,"18.2075",{"$nulls":3},"blood coagulation;neutrophil degranulation;positive regulation of blood coagulation;purine ribonucleoside catabolic process","bis(5'-adenosyl)-triphosphatase activity;metal ion binding","extracellular exosome;ficolin-1-rich granule membrane;integral component of membrane;membrane;plasma membrane","Metabolic pathways;Purine metabolism",null,null,3,3,2,"7.5","7.5","5.3","51.641","0.00042845","4.9382",19286000,4,"0.0039435",1,"0.0956999","0.0120526","sp|Q9Y6X5|ENPP4_HUMAN","sp|Q9Y6X5|ENPP4_HUMAN",5426,"Q9Y6X5","ENPP4_HUMAN","Bis(5'-adenosyl)-triphosphatase ENPP4",null,"ENPP4"]
["23.5783","21.8709","22.8378","23.3327","22.1555","22.513",{"$nulls":3},"cellular response to leukemia inhibitory factor;polyamine metabolic process;spermidine biosynthetic process","identical protein binding;protein homodimerization activity;spermidine synthase activity","cytosol","Arginine and proline metabolism;beta-Alanine metabolism;Cysteine and methionine metabolism;Glutathione metabolism;Metabolic pathways",null,null,10,10,10,44,44,44,"33.824",0,"78.653",1104500000,54,"0.0543161",1,"0.0952873","0.15756","sp|P19623|SPEE_HUMAN;tr|K7EQ47|K7EQ47_HUMAN;tr|K7EKM4|K7EKM4_HUMAN;tr|K7EL89|K7EL89_HUMAN;tr|K7ESL0|K7ESL0_HUMAN","sp|P19623|SPEE_HUMAN",1197,"P19623","SPEE_HUMAN","Spermidine synthase","PDSY","SRM"]
["23.3169","21.7671","22.9198","23.005","21.7303","22.9862",{"$nulls":3},"cellular response to epidermal growth factor stimulus;cellular response to insulin stimulus;cellular response to platelet-derived growth factor stimulus;cellular response to starvation;methionyl-tRNA aminoacylation;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;rRNA transcription;tRNA aminoacylation for protein translation","ATP binding;methionine-tRNA ligase activity;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;extracellular exosome;membrane;nucleolus","Aminoacyl-tRNA biosynthesis;Metabolic pathways;Selenocompound metabolism",null,null,29,29,29,"40.2","40.2","40.2","101.11",0,"323.31",6277400000,384,"0.0515381",1,"0.0940812","0.149898","sp|P56192|SYMC_HUMAN;tr|H0YHV5|H0YHV5_HUMAN;tr|H0YIP0|H0YIP0_HUMAN;tr|H0YI94|H0YI94_HUMAN;tr|F5H2V6|F5H2V6_HUMAN;tr|H0YIC2|H0YIC2_HUMAN;tr|H0YHL6|H0YHL6_HUMAN;tr|H0YI27|H0YI27_HUMAN","sp|P56192|SYMC_HUMAN",1861,"P56192","SYMC_HUMAN","Methionine--tRNA ligase, cytoplasmic",null,"MARS"]
["22.8045","21.6974","22.5285","22.7767","21.3026","22.6692",{"$nulls":3},"protein oligomerization;regulation of RNA splicing;regulation of voltage-gated calcium channel activity","cadherin binding;RNA binding;S100 protein binding;structural molecule activity conferring elasticity","actin cytoskeleton;cell-cell contact zone;costamere;cytoplasm;cytosol;extracellular exosome;focal adhesion;lysosomal membrane;membrane;nucleus;plasma membrane;sarcolemma;T-tubule;vesicle",{"$nulls":3},218,218,216,"66.4","66.4","66.1","629.09",0,"323.31",27565000000,1470,"0.0559853",1,"0.0939598","0.162146","sp|Q09666|AHNK_HUMAN;tr|E9PKR9|E9PKR9_HUMAN;tr|E9PLK4|E9PLK4_HUMAN;tr|E9PJZ0|E9PJZ0_HUMAN;tr|E9PJC6|E9PJC6_HUMAN;tr|E9PQE3|E9PQE3_HUMAN;sp|P48552|NRIP1_HUMAN","sp|Q09666|AHNK_HUMAN",2246,"Q09666","AHNK_HUMAN","Neuroblast differentiation-associated protein AHNAK",null,"AHNAK"]
["23.8207","22.4149","23.3359","23.792","22.2677","23.2334",{"$nulls":3},"cell-cell junction assembly;cell-substrate junction assembly;cortical actin cytoskeleton organization;cytoskeletal anchoring at plasma membrane;integrin activation;integrin-mediated signaling pathway;IRE1-mediated unfolded protein response;movement of cell or subcellular component;muscle contraction;platelet aggregation;platelet degranulation;viral process","actin filament binding;cadherin binding;integrin binding;LIM domain binding;phosphatidylinositol binding;phosphatidylserine binding;structural constituent of cytoskeleton;vinculin binding","cell surface;cell-cell junction;cytoskeleton;cytosol;extracellular exosome;extracellular region;focal adhesion;ruffle;ruffle membrane","Focal adhesion;Human T-cell leukemia virus 1 infection;Platelet activation;Rap1 signaling pathway",null,null,93,93,86,"56.3","56.3","53.2","269.76",0,"323.31",12717000000,615,"0.052648",1,"0.092823","0.152963","sp|Q9Y490|TLN1_HUMAN","sp|Q9Y490|TLN1_HUMAN",5316,"Q9Y490","TLN1_HUMAN","Talin-1",null,"TLN1"]
["17.7832","16.1236","17.9036","18.0044","16.1234","17.408",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular response to UV;embryonic digit morphogenesis;histone acetylation;homeostatic process;negative regulation of transcription from RNA polymerase II promoter;Notch signaling pathway;N-terminal peptidyl-lysine acetylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;protein acetylation;protein complex assembly;protein destabilization;regulation of apoptotic process;regulation of cellular response to heat;regulation of lipid metabolic process;regulation of myeloid cell differentiation;regulation of smoothened signaling pathway;regulation of transcription from RNA polymerase II promoter in response to hypoxia;regulation of transcription, DNA-templated;response to hypoxia;rhythmic process;signal transduction;stimulatory C-type lectin receptor signaling pathway;transcription initiation from RNA polymerase II promoter;viral process","acetyltransferase activity;chromatin binding;damaged DNA binding;DNA binding transcription factor activity;histone acetyltransferase activity;MRF binding;p53 binding;peptide N-acetyltransferase activity;proximal promoter sequence-specific DNA binding;RNA polymerase II activating transcription factor binding;RNA polymerase II transcription coactivator activity;RNA polymerase II transcription factor binding;signal transducer activity;transcription coactivator activity;transcription factor binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription factor binding;zinc ion binding","cytoplasm;histone acetyltransferase complex;nuclear body;nuclear chromatin;nucleoplasm;nucleus","Adherens junction;cAMP signaling pathway;Cell cycle;FoxO signaling pathway;Glucagon signaling pathway;Hepatitis B;HIF-1 signaling pathway;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term potentiation;Melanogenesis;MicroRNAs in cancer;Notch signaling pathway;Pathways in cancer;Prostate cancer;Renal cell carcinoma;TGF-beta signaling pathway;Thyroid hormone signaling pathway;Tuberculosis;Viral carcinogenesis;Wnt signaling pathway",null,null,16,16,12,"10.7","10.7","8.6","265.35",0,"144.06",392990000,60,"0.0389081",1,"0.0915006","0.11457","sp|Q92793|CBP_HUMAN;tr|I3L466|I3L466_HUMAN;tr|I3L3I5|I3L3I5_HUMAN;tr|I3L0Q1|I3L0Q1_HUMAN","sp|Q92793|CBP_HUMAN",3715,"Q92793","CBP_HUMAN","CREB-binding protein",null,"CREBBP"]
["25.8085","24.1536","25.5887","25.4017","24.0991","25.7773",{"$nulls":3},"negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of protein neddylation;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of ubiquitin protein ligase activity;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of gene expression;positive regulation of protein binding;protein localization to nucleus;protein stabilization;protein targeting;regulation of signal transduction by p53 class mediator;ribosomal large subunit assembly;ribosomal large subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","5S rRNA binding;RNA binding;structural constituent of ribosome;ubiquitin ligase inhibitor activity;ubiquitin protein ligase binding","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;membrane;nucleolus;nucleoplasm;protein complex","Ribosome",null,null,10,10,10,"59.6","59.6","59.6","20.252",0,"223.17",21637000000,374,"0.0426532",1,"0.0909106","0.125132","sp|P62913|RL11_HUMAN;tr|Q5VVC8|Q5VVC8_HUMAN;tr|Q5VVC9|Q5VVC9_HUMAN","sp|P62913|RL11_HUMAN;tr|Q5VVC8|Q5VVC8_HUMAN;tr|Q5VVC9|Q5VVC9_HUMAN",2010,"P62913","RL11_HUMAN","60S ribosomal protein L11",null,"RPL11"]
["23.2421","22.6036","23.4847","23.1609","22.4545","23.4442",{"$nulls":9},1,1,1,"15.9","15.9","15.9","8.023",0,"9.1164",228380000,14,"0.0807809",1,"0.0902557","0.228768","tr|K7ELP0|K7ELP0_HUMAN","tr|K7ELP0|K7ELP0_HUMAN",5595,"K7ELP0","K7ELP0_HUMAN",null,null,"TPM4"]
["18.9771","15.5744","17.5817","18.4179","15.8459","17.6015",{"$nulls":3},"protein ubiquitination;small GTPase mediated signal transduction;viral process","enzyme activator activity;GDP binding;GTP binding;GTPase activity;identical protein binding;nucleic acid binding;ubiquitin-protein transferase activity;zinc ion binding","extracellular exosome;Golgi membrane;lysosomal membrane;nucleus",{"$nulls":3},2,2,2,"7.3","7.3","7.3","64.066","0.00042517","4.7627",55828000,14,"0.0239713",1,"0.089268","0.071677","sp|P36406|TRI23_HUMAN","sp|P36406|TRI23_HUMAN",1480,"P36406","TRI23_HUMAN","E3 ubiquitin-protein ligase TRIM23",null,"TRIM23"]
["21.5343","16.2675","20.4211","21.2077","16.2823","20.4666",{"$nulls":3},"anterior/posterior pattern specification;camera-type eye morphogenesis;histone H2A monoubiquitination;negative regulation of G0 to G1 transition;negative regulation of transcription, DNA-templated;transcription, DNA-templated","chromatin binding;metal ion binding;transferase activity;ubiquitin-protein transferase activator activity","cytosol;nuclear speck;nucleoplasm;nucleus;PcG protein complex;PRC1 complex;sex chromatin",{"$nulls":3},6,6,5,"25.9","25.9","22.4","42.429",0,"23.629",625140000,31,"0.0132277",1,"0.0887438","0.0400116","sp|Q06587|RING1_HUMAN","sp|Q06587|RING1_HUMAN",2208,"Q06587","RING1_HUMAN","E3 ubiquitin-protein ligase RING1",null,"RING1"]
["21.9546","20.0577","21.4345","21.7411","19.9958","21.4477",{"$nulls":3},"pseudouridine synthesis;tRNA processing","enzyme binding;pseudouridine synthase activity;RNA binding","nucleus",{"$nulls":3},25,25,25,"56.1","56.1","56.1","75.035",0,"263.51",873870000,82,"0.0379457",1,"0.0874507","0.111844","sp|Q96PZ0|PUS7_HUMAN;tr|E7EUH7|E7EUH7_HUMAN;tr|H0Y863|H0Y863_HUMAN","sp|Q96PZ0|PUS7_HUMAN;tr|E7EUH7|E7EUH7_HUMAN",4000,"Q96PZ0","PUS7_HUMAN","Pseudouridylate synthase 7 homolog",null,"PUS7"]
["23.7017","21.7785","22.5749","23.2495","22.0627","22.484",{"$nulls":3},"microtubule-based process","GTP binding;GTPase activity;structural constituent of cytoskeleton","cytoplasm;extracellular exosome;microtubule;microtubule cytoskeleton;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,21,10,10,"61.7",37,37,"49.857",0,"214.24",1325400000,74,"0.0448493",1,"0.0862834","0.131291","sp|Q9BUF5|TBB6_HUMAN;tr|K7ESM5|K7ESM5_HUMAN;tr|K7EL29|K7EL29_HUMAN;tr|K7EN98|K7EN98_HUMAN;tr|K7ESQ3|K7ESQ3_HUMAN;tr|K7EQT3|K7EQT3_HUMAN;tr|K7EJ64|K7EJ64_HUMAN;tr|K7ERA8|K7ERA8_HUMAN;tr|K7EJZ4|K7EJZ4_HUMAN;tr|K7ES63|K7ES63_HUMAN;tr|K7EPE5|K7EPE5_HUMAN","sp|Q9BUF5|TBB6_HUMAN;tr|K7ESM5|K7ESM5_HUMAN",4224,"Q9BUF5","TBB6_HUMAN","Tubulin beta-6 chain",null,"TUBB6"]
["22.9366","21.5382","22.1497","23.0727","21.2161","22.0809",{"$nulls":3},"autophagy;cell proliferation;cellular calcium ion homeostasis;cellular water homeostasis;epithelial cell differentiation;hemostasis;membrane fusion;negative regulation of gene expression;regulation of cell shape;response to calcium ion;response to organic cyclic compound;response to salt stress;social behavior","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;integrin binding;RNA binding","cytosol;endoplasmic reticulum membrane;extracellular exosome;membrane;nuclear envelope;nucleus;plasma membrane",{"$nulls":3},16,16,16,"35.2","35.2","35.2","52.739",0,"57.899",1216900000,57,"0.0431113",1,"0.084947","0.126418","sp|P20073|ANXA7_HUMAN","sp|P20073|ANXA7_HUMAN",1204,"P20073","ANXA7_HUMAN","Annexin A7",null,"ANXA7"]
["18.8535","19.5443","19.3819","19.6563","18.7547","19.1165",{"$nulls":4},"ATP binding;protein kinase activity",{"$nulls":4},33,33,20,"32.5","32.5",23,"144.92",0,"184.35",2748100000,202,"0.0892821",1,"0.0840416","0.251007","tr|E7EN19|E7EN19_HUMAN;tr|E7ESS2|E7ESS2_HUMAN;tr|E7ENQ1|E7ENQ1_HUMAN;tr|H7C360|H7C360_HUMAN;sp|O95819|M4K4_HUMAN;tr|G3XAA2|G3XAA2_HUMAN;tr|G5E948|G5E948_HUMAN;tr|A0A0D9SEY1|A0A0D9SEY1_HUMAN;tr|E7EX83|E7EX83_HUMAN;tr|A0A0D9SG62|A0A0D9SG62_HUMAN;tr|C9J840|C9J840_HUMAN;tr|H7C0P6|H7C0P6_HUMAN;tr|E7ETN6|E7ETN6_HUMAN;tr|H7C3Z6|H7C3Z6_HUMAN","tr|E7EN19|E7EN19_HUMAN;tr|E7ESS2|E7ESS2_HUMAN;tr|E7ENQ1|E7ENQ1_HUMAN;tr|H7C360|H7C360_HUMAN;sp|O95819|M4K4_HUMAN;tr|G3XAA2|G3XAA2_HUMAN;tr|G5E948|G5E948_HUMAN;tr|A0A0D9SEY1|A0A0D9SEY1_HUMAN;tr|E7EX83|E7EX83_HUMAN;tr|A0A0D9SG62|A0A0D9SG62_HUMAN;tr|C9J840|C9J840_HUMAN;tr|H7C0P6|H7C0P6_HUMAN",5497,"E7EN19","E7EN19_HUMAN",null,null,"MAP4K4"]
["24.1379","22.5945","23.1391","23.8925","22.3095","23.4189",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;ciliary basal body-plasma membrane docking;ER to Golgi vesicle-mediated transport;G2/M transition of mitotic cell cycle;regulation of G2/M transition of mitotic cell cycle;spermatogenesis;vesicle-mediated transport","ATP binding","cell cortex region;centriole;centrosome;COPI-coated vesicle;cytoplasm;cytosol;dynactin complex;extracellular exosome;manchette;microtubule associated complex;microtubule cytoskeleton;myelin sheath",{"$nulls":3},11,11,5,"46.5","46.5","24.5","42.613",0,"171.36",2087000000,98,"0.0437491",1,"0.083512","0.128208","sp|P61163|ACTZ_HUMAN;tr|R4GMT0|R4GMT0_HUMAN","sp|P61163|ACTZ_HUMAN;tr|R4GMT0|R4GMT0_HUMAN",1921,"P61163","ACTZ_HUMAN","Alpha-centractin","entractin","ACTR1A"]
["23.2575","22.143","22.9035","23.1591","22.0409","22.8541",{"$nulls":3},"cell cycle;cellular response to DNA damage stimulus;mitochondrial fragmentation involved in apoptotic process;mRNA processing;negative regulation of catalytic activity;negative regulation of cell growth;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of transcription, DNA-templated;positive regulation of apoptotic process;positive regulation of canonical Wnt signaling pathway;positive regulation of DNA damage checkpoint;regulation of cellular response to heat;regulation of circadian rhythm;regulation of DNA-templated transcription, elongation;regulation of protein deacetylation;regulation of protein stability;response to UV;rhythmic process;RNA splicing;transcription, DNA-templated;Wnt signaling pathway","enzyme binding;enzyme inhibitor activity;RNA binding;RNA polymerase II core binding","cytoplasm;DBIRD complex;mitochondrial matrix;nuclear chromatin;nucleoplasm;nucleus",{"$nulls":3},37,37,37,"53.5","53.5","53.5","102.9",0,"315.72",3759800000,241,"0.0617276",1,"0.0833104","0.177821","sp|Q8N163|CCAR2_HUMAN;tr|G3V119|G3V119_HUMAN;tr|H0YB24|H0YB24_HUMAN;tr|E5RFJ3|E5RFJ3_HUMAN;tr|A0A087X2B6|A0A087X2B6_HUMAN;tr|H0YC69|H0YC69_HUMAN;tr|E5RGU7|E5RGU7_HUMAN;tr|H0YC58|H0YC58_HUMAN;tr|E5RHJ4|E5RHJ4_HUMAN;tr|E5RHH8|E5RHH8_HUMAN","sp|Q8N163|CCAR2_HUMAN;tr|G3V119|G3V119_HUMAN;tr|H0YB24|H0YB24_HUMAN",3372,"Q8N163","CCAR2_HUMAN","Cell cycle and apoptosis regulator protein 2",null,"CCAR2"]
[1,"15.6284","20.3097",1,"15.7633","19.9265",{"$nulls":3},"nucleosome assembly","enzyme binding","nucleolus;nucleus",{"$nulls":3},4,4,4,"17.6","17.6","17.6","49.192",0,"27.728",284510000,34,"0.00331179",1,"0.0827821","0.0101291","sp|Q9H0U9|TSYL1_HUMAN","sp|Q9H0U9|TSYL1_HUMAN",4401,"Q9H0U9","TSYL1_HUMAN","Testis-specific Y-encoded-like protein 1","SPY-like protein 1","TSPYL1"]
["18.7107","17.8142","18.8896","18.4741","18.5509","18.1416",{"$nulls":3},"ubiquinone biosynthetic process","FAD binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen",{"$nulls":4},3,3,3,"10.9","10.9","10.9","43.131",0,"6.5485",40759000,5,"0.082186",1,"0.0826619","0.232464","tr|A0A0D9SFJ1|A0A0D9SFJ1_HUMAN;tr|G3XA86|G3XA86_HUMAN;sp|Q9Y2Z9|COQ6_HUMAN;tr|G3V3A1|G3V3A1_HUMAN","tr|A0A0D9SFJ1|A0A0D9SFJ1_HUMAN;tr|G3XA86|G3XA86_HUMAN;sp|Q9Y2Z9|COQ6_HUMAN",5259,"A0A0D9SFJ1","A0A0D9SFJ1_HUMAN"]
["24.6671","23.7875","24.1393","24.5346","23.6491","24.1671",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;osteoblast differentiation;positive regulation of canonical Wnt signaling pathway;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent ERAD pathway;ubiquitin-dependent protein catabolic process;viral process;Wnt signaling pathway, planar cell polarity pathway","ATP binding;ATPase activity;proteasome-activating ATPase activity;TBP-class protein binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;cytosolic proteasome complex;extracellular region;ficolin-1-rich granule lumen;membrane;nuclear proteasome complex;nucleoplasm;nucleus;P-body;proteasome accessory complex;proteasome complex;proteasome regulatory particle, base subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,28,28,28,"69.3","69.3","69.3","48.633",0,"323.31",5632400000,227,"0.078811",1,"0.0810165","0.223573","sp|P35998|PRS7_HUMAN;tr|C9JLS9|C9JLS9_HUMAN","sp|P35998|PRS7_HUMAN",1477,"P35998","PRS7_HUMAN","26S proteasome regulatory subunit 7",null,"PSMC2"]
["24.1451","22.5252","22.5849","23.8706","22.5551","22.5898",{"$nulls":3},"apoptotic process;cellular protein metabolic process;cellular response to glucose stimulus;cellular response to organic cyclic compound;myoblast differentiation;negative regulation of cell-substrate adhesion;negative regulation of neuron projection development;plasma cell differentiation;positive regulation of erythrocyte aggregation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of viral entry into host cell;post-translational protein modification;regulation of apoptotic process;response to axon injury;response to drug;response to isolation stress;T cell costimulation","lactose binding;laminin binding;protein homodimerization activity;RNA binding;signal transducer activity","cell surface;cytoplasm;cytosol;endoplasmic reticulum lumen;extracellular exosome;extracellular matrix;extracellular region;extracellular space;intracellular;nucleus;proteinaceous extracellular matrix",{"$nulls":3},7,7,7,60,60,60,"14.716",0,"37.055",793580000,52,"0.0396611",1,"0.079881","0.116699","sp|P09382|LEG1_HUMAN;tr|F8WEI7|F8WEI7_HUMAN","sp|P09382|LEG1_HUMAN",986,"P09382","LEG1_HUMAN","Galectin-1","al-1","LGALS1"]
["22.7016","20.783","21.0749","22.2217","20.6977","21.4035",{"$nulls":3},"intracellular protein transport;regulation of macroautophagy;retrograde transport, endosome to Golgi;retrograde transport, endosome to plasma membrane;Wnt signaling pathway","protein transporter activity","cytosol;early endosome;endosome;endosome membrane;extracellular exosome;lysosome;retromer complex;retromer, cargo-selective complex;tubular endosome;vesicle","Endocytosis",null,null,14,14,13,"53.8","53.8","51.7","38.169",0,"50.717",727240000,47,"0.0360076",1,"0.0788727","0.106338","sp|O75436|VP26A_HUMAN;tr|S4R3Q6|S4R3Q6_HUMAN;tr|S4R2Y3|S4R2Y3_HUMAN","sp|O75436|VP26A_HUMAN;tr|S4R3Q6|S4R3Q6_HUMAN",588,"O75436","VP26A_HUMAN","Vacuolar protein sorting-associated protein 26A",null,"VPS26A"]
["17.8373","13.9707","15.7235","17.7157","13.5971","15.9862",{"$nulls":3},"cellular response to DNA damage stimulus;chromosome organization involved in meiotic cell cycle;DNA double-strand break processing;DNA duplex unwinding;DNA recombination;DNA repair;DNA replication;DNA synthesis involved in DNA repair;double-strand break repair;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;negative regulation of telomere capping;nucleic acid phosphodiester bond hydrolysis;positive regulation of kinase activity;positive regulation of protein autophosphorylation;positive regulation of telomere maintenance;reciprocal meiotic recombination;regulation of mitotic recombination;regulation of signal transduction by p53 class mediator;strand displacement;telomere maintenance;telomere maintenance via recombination;telomere maintenance via telomerase;telomeric 3' overhang formation;viral process","adenylate kinase activity;ATP binding;ATPase activity;DNA binding;double-stranded telomeric DNA binding;G-quadruplex DNA binding;metal ion binding;protein binding, bridging;single-stranded telomeric DNA binding","condensed nuclear chromosome;membrane;Mre11 complex;nuclear chromatin;nuclear chromosome, telomeric region;nucleoplasm;site of double-strand break","Cellular senescence;Homologous recombination;Non-homologous end-joining",null,null,5,5,5,"4.6","4.6","4.6","153.89",0,"13.397",73712000,8,"0.0157117",1,"0.0775216","0.0473968","sp|Q92878|RAD50_HUMAN;tr|E7EN38|E7EN38_HUMAN;tr|H7C0P8|H7C0P8_HUMAN;tr|E7ESD9|E7ESD9_HUMAN","sp|Q92878|RAD50_HUMAN",3727,"Q92878","RAD50_HUMAN","DNA repair protein RAD50","RAD50","RAD50"]
["19.6968","19.8154","18.2652","19.7097","19.5007","18.3428",{"$nulls":4},"transferase activity","cytosol;nucleoplasm",{"$nulls":3},4,4,4,"23.5","23.5","23.5","25.948",0,"6.283",81383000,11,"0.0387445",1,"0.0747267","0.114107","tr|Q6ICJ4|Q6ICJ4_HUMAN;tr|G9J6Q5|G9J6Q5_HUMAN;sp|P0CG30|GSTT2_HUMAN;tr|A0A087WY67|A0A087WY67_HUMAN;sp|P0CG29|GST2_HUMAN;tr|A0A0G2JMS2|A0A0G2JMS2_HUMAN;tr|A0A0G2JQD8|A0A0G2JQD8_HUMAN;tr|A0A0G2JRG0|A0A0G2JRG0_HUMAN;tr|A0A0G2JQM5|A0A0G2JQM5_HUMAN;tr|A0A0G2JQD2|A0A0G2JQD2_HUMAN;tr|A0A0G2JQM0|A0A0G2JQM0_HUMAN;tr|A0A0G2JRN4|A0A0G2JRN4_HUMAN;tr|A0A0G2JRJ5|A0A0G2JRJ5_HUMAN;tr|A0A0G2JRQ5|A0A0G2JRQ5_HUMAN;sp|P30711|GSTT1_HUMAN","tr|Q6ICJ4|Q6ICJ4_HUMAN;tr|G9J6Q5|G9J6Q5_HUMAN;sp|P0CG30|GSTT2_HUMAN;tr|A0A087WY67|A0A087WY67_HUMAN;sp|P0CG29|GST2_HUMAN",1009,"Q6ICJ4","Q6ICJ4_HUMAN",null,null,"Em:AP000351.3"]
["19.9409","19.3547","17.8374","19.9572","19.1164","17.8408",{"$nulls":3},"calcium ion regulated exocytosis;endocytosis;endosome to lysosome transport;eosinophil degranulation;ER to Golgi vesicle-mediated transport;Golgi to plasma membrane protein transport;membrane organization;natural killer cell degranulation;neutrophil degranulation;phagocytosis, engulfment;positive regulation of dendrite morphogenesis;positive regulation of histamine secretion by mast cell;post-Golgi vesicle-mediated transport;regulation of protein targeting to vacuolar membrane;SNARE complex assembly;triglyceride transport;vesicle fusion;vesicle fusion with Golgi apparatus;vesicle transport along microtubule;vesicle-mediated transport","SNAP receptor activity;SNARE binding;syntaxin binding","apical part of cell;azurophil granule membrane;cell junction;cell surface;clathrin-coated vesicle membrane;cytoplasm;endoplasmic reticulum membrane;extracellular exosome;integral component of synaptic vesicle membrane;intracellular membrane-bounded organelle;lamellipodium;late endosome membrane;lysosomal membrane;membrane;neuron projection;perinuclear region of cytoplasm;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane;platelet alpha granule;pseudopodium;secretory granule;secretory granule membrane;SNARE complex;trans-Golgi network","SNARE interactions in vesicular transport",null,null,4,4,4,"18.6","18.6","18.6","24.935",0,"10.525",120670000,8,"0.0278784",1,"0.0729116","0.0830196","sp|P51809|VAMP7_HUMAN","sp|P51809|VAMP7_HUMAN",1755,"P51809","VAMP7_HUMAN","Vesicle-associated membrane protein 7","AMP-7","VAMP7"]
["25.6124","23.6995","24.927","25.4443","23.4732","25.1048",{"$nulls":3},"gene silencing by RNA;mRNA polyadenylation;mRNA splicing, via spliceosome;mRNA stabilization;negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of viral genome replication;regulation of mRNA stability;translational initiation","mRNA 3'-UTR binding;poly(A) binding;poly(U) RNA binding;protein C-terminus binding;RNA binding;translation activator activity","catalytic step 2 spliceosome;cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleus","mRNA surveillance pathway;RNA degradation;RNA transport",null,null,31,31,20,"55.2","55.2","37.4","70.67",0,"323.31",10819000000,330,"0.0293866",1,"0.0722211","0.0873743","sp|P11940|PABP1_HUMAN;tr|E7EQV3|E7EQV3_HUMAN;tr|E7ERJ7|E7ERJ7_HUMAN;tr|A0A087WTT1|A0A087WTT1_HUMAN;tr|H0YAR2|H0YAR2_HUMAN;sp|Q9H361|PABP3_HUMAN;tr|H0YBN4|H0YBN4_HUMAN;tr|H0YAS6|H0YAS6_HUMAN;tr|H0YB75|H0YB75_HUMAN;tr|E5RJB9|E5RJB9_HUMAN;tr|E5RGH3|E5RGH3_HUMAN;tr|E5RH24|E5RH24_HUMAN;tr|H0YAP2|H0YAP2_HUMAN;tr|H0YAS7|H0YAS7_HUMAN;tr|H0YB86|H0YB86_HUMAN;sp|Q4VXU2|PAP1L_HUMAN;tr|E5RHG7|E5RHG7_HUMAN;tr|H0YAW6|H0YAW6_HUMAN;tr|H0YC10|H0YC10_HUMAN;tr|E5RGC4|E5RGC4_HUMAN;tr|E5RFD8|E5RFD8_HUMAN;tr|E5RJM8|E5RJM8_HUMAN;sp|Q96DU9|PABP5_HUMAN","sp|P11940|PABP1_HUMAN;tr|E7EQV3|E7EQV3_HUMAN;tr|E7ERJ7|E7ERJ7_HUMAN;tr|A0A087WTT1|A0A087WTT1_HUMAN",1056,"P11940","PABP1_HUMAN","Polyadenylate-binding protein 1","ABP-1;oly(A)-binding protein 1","PABPC1"]
[1,"17.7322","18.7858",1,"17.8684","18.4394",{"$nulls":9},1,1,1,"9.9","9.9","9.9","13.16","0.0028479","2.8348",18180000,1,"0.00282082",1,"0.0700823","0.00863231","tr|M0QYH6|M0QYH6_HUMAN;tr|M0QY25|M0QY25_HUMAN;sp|Q86YD1|PTOV1_HUMAN","tr|M0QYH6|M0QYH6_HUMAN;tr|M0QY25|M0QY25_HUMAN;sp|Q86YD1|PTOV1_HUMAN",3268,"M0QYH6","M0QYH6_HUMAN",null,null,"PTOV1"]
["24.3504","23.5613","23.9213","24.4085","23.1954","24.0195",{"$nulls":3},"translational initiation;viral translational termination-reinitiation","RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex;fibrillar center;membrane;nucleoplasm",{"$nulls":3},27,27,27,"53.2","53.2","53.2","66.726",0,"323.31",4862600000,209,"0.0569092",1,"0.0698516","0.164678","sp|Q9Y262|EIF3L_HUMAN;tr|B0QY89|B0QY89_HUMAN;tr|B0QY90|B0QY90_HUMAN;tr|C9JHP4|C9JHP4_HUMAN;tr|C9K0Q7|C9K0Q7_HUMAN;tr|H7C3A0|H7C3A0_HUMAN;tr|H0Y7E6|H0Y7E6_HUMAN","sp|Q9Y262|EIF3L_HUMAN;tr|B0QY89|B0QY89_HUMAN;tr|B0QY90|B0QY90_HUMAN",5203,"Q9Y262","EIF3L_HUMAN","Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011}","IF3l {ECO:0000255|HAMAP-Rule:MF_03011}","EIF3L"]
["20.3172","19.3702","20.1294","20.4079","18.9932","20.2112",{"$nulls":3},"cornification;desmosome assembly;keratinization;negative regulation of mRNA catabolic process;positive regulation of gene expression;protein localization to plasma membrane","alpha-catenin binding;cadherin binding involved in cell-cell adhesion;cell adhesion molecule binding;enzyme binding","cell junction;cell-cell adherens junction;cell-cell junction;cornified envelope;desmosome;messenger ribonucleoprotein complex;nucleoplasm;plasma membrane",{"$nulls":3},31,31,31,"46.2","46.2","46.2","87.081",0,"157.94",1400300000,145,"0.0440076",1,"0.0681693","0.128933","sp|Q9Y446|PKP3_HUMAN;tr|E9PKC4|E9PKC4_HUMAN;tr|E9PRW6|E9PRW6_HUMAN;tr|E9PK71|E9PK71_HUMAN;tr|E9PJR7|E9PJR7_HUMAN;tr|E9PQ15|E9PQ15_HUMAN;tr|H0YEY5|H0YEY5_HUMAN","sp|Q9Y446|PKP3_HUMAN",5313,"Q9Y446","PKP3_HUMAN","Plakophilin-3",null,"PKP3"]
["23.1234","20.9731","21.7288","22.1346","21.3349","22.1531",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;histone H3-K4 trimethylation;negative regulation of myeloid cell differentiation;positive regulation of histone H3-K4 methylation;positive regulation of histone H3-K79 methylation;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein ubiquitination;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;Wnt signaling pathway",null,"Cdc73/Paf1 complex;cytoplasm;cytosol;nucleoplasm;nucleus;Ski complex;transcriptionally active chromatin","RNA degradation",null,null,9,9,9,"49.8","49.8","49.8","33.58",0,"116.82",693180000,58,"0.0333074",1,"0.0675761","0.0986339","sp|Q9GZS3|WDR61_HUMAN;tr|H0YN81|H0YN81_HUMAN;tr|H0YMF9|H0YMF9_HUMAN;tr|H0YL19|H0YL19_HUMAN;tr|H0YM76|H0YM76_HUMAN;tr|H3BQA8|H3BQA8_HUMAN;tr|H0YLA1|H0YLA1_HUMAN","sp|Q9GZS3|WDR61_HUMAN;tr|H0YN81|H0YN81_HUMAN;tr|H0YMF9|H0YMF9_HUMAN;tr|H0YL19|H0YL19_HUMAN",4367,"Q9GZS3","WDR61_HUMAN","WD repeat-containing protein 61",null,"WDR61"]
["20.1283","18.4211","18.5578","20.0348","18.3403","18.5313",{"$nulls":3},"negative regulation of transcription, DNA-templated","metal ion binding","focal adhesion;nucleus;plasma membrane",{"$nulls":3},7,7,7,19,19,19,"65.534",0,"64.613",178970000,13,"0.0293859",1,"0.0669479","0.0873722","tr|C9JRJ5|C9JRJ5_HUMAN;sp|Q9UGP4|LIMD1_HUMAN","tr|C9JRJ5|C9JRJ5_HUMAN;sp|Q9UGP4|LIMD1_HUMAN",5004,"C9JRJ5","C9JRJ5_HUMAN",null,null,"LIMD1"]
["24.1005","22.5381","23.6901","24.1578","22.2494","23.726",{"$nulls":3},"cellular response to leukemia inhibitory factor;mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;regulation of mRNA splicing, via spliceosome;RNA export from nucleus;termination of RNA polymerase II transcription","phospholipase binding;RNA binding;sequence-specific mRNA binding","cytoplasm;nuclear speck;nucleoplasm","Herpes simplex virus 1 infection;Spliceosome",null,null,6,5,5,"36.6","36.6","36.6","19.329",0,"50.627",1037700000,39,"0.0294966",1,"0.0651817","0.0876913","sp|P84103|SRSF3_HUMAN;tr|A0A087X2D0|A0A087X2D0_HUMAN","sp|P84103|SRSF3_HUMAN;tr|A0A087X2D0|A0A087X2D0_HUMAN",2100,"P84103","SRSF3_HUMAN","Serine/arginine-rich splicing factor 3",null,"SRSF3"]
["21.5567","19.2663","20.8945","21.3946","19.4581","20.6739",{"$nulls":3},"ribosomal protein import into nucleus;transcription factor import into nucleus","protein transporter activity;Ran GTPase binding","cytosol;fibrillar center;nuclear envelope;nucleus",{"$nulls":3},18,18,18,"26.3","26.3","26.3","112.53",0,"323.31",689890000,73,"0.0240575",1,"0.0636222","0.0719284","sp|Q9UI26|IPO11_HUMAN;tr|F8WDV0|F8WDV0_HUMAN;tr|D6RJB1|D6RJB1_HUMAN;tr|D6RCN7|D6RCN7_HUMAN;tr|E7EMB7|E7EMB7_HUMAN;tr|H0Y8M5|H0Y8M5_HUMAN;tr|D6RCQ2|D6RCQ2_HUMAN","sp|Q9UI26|IPO11_HUMAN;tr|F8WDV0|F8WDV0_HUMAN",5043,"Q9UI26","IPO11_HUMAN","Importin-11","mp11","IPO11"]
["20.8808","20.9095","20.6829","21.4719","20.3347","20.4784",{"$nulls":3},"positive regulation of gene expression, epigenetic;rRNA transcription;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription initiation from RNA polymerase I promoter;transmembrane receptor protein tyrosine kinase signaling pathway","DNA-directed 5'-3' RNA polymerase activity;RNA binding","chromosome;cytosol;fibrillar center;mitochondrion;nucleolus;nucleoplasm;nucleus;RNA polymerase I transcription factor complex",{"$nulls":3},16,16,16,"55.9","55.9","55.9","54.985",0,"202.97",2349000000,218,"0.0596003",1,"0.0627174","0.172032","sp|O15446|RPA34_HUMAN","sp|O15446|RPA34_HUMAN",378,"O15446","RPA34_HUMAN","DNA-directed RNA polymerase I subunit RPA34",null,"CD3EAP"]
["20.1412","16.8016","18.4535","19.5008","17.0622","18.6478",{"$nulls":3},"mRNA processing;regulation of alternative mRNA splicing, via spliceosome;RNA splicing",null,"cytoplasm;nuclear speck",{"$nulls":3},10,10,10,"26.3","26.3","26.3","57.543",0,"45.286",185470000,38,"0.0171037",1,"0.0618203","0.0515184","sp|Q2TAY7|SMU1_HUMAN","sp|Q2TAY7|SMU1_HUMAN",2725,"Q2TAY7","SMU1_HUMAN","WD40 repeat-containing protein SMU1",null,"SMU1"]
["21.8076","20.3349","21.4409","21.4596","20.419","21.5221",{"$nulls":3},"ATP metabolic process;protein folding;proteolysis involved in cellular protein catabolic process","ATP binding;ATPase activity;metal ion binding;peptidase activator activity;unfolded protein binding","cytosol;endopeptidase Clp complex;mitochondrial endopeptidase Clp complex;mitochondrial inner membrane;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleoplasm",{"$nulls":3},19,19,19,"38.1","38.1","38.1","69.223",0,"100.98",1125500000,96,"0.0362739",1,"0.0609493","0.107096","sp|O76031|CLPX_HUMAN;tr|H0YM48|H0YM48_HUMAN;tr|H0YK07|H0YK07_HUMAN","sp|O76031|CLPX_HUMAN",663,"O76031","CLPX_HUMAN","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial",null,"CLPX"]
["22.9261","22.3297","22.9424","23.2342","22.047","22.7349",{"$nulls":3},"protein deneddylation",null,"COP9 signalosome",{"$nulls":3},17,17,17,"41.8","41.8","41.8","53.371",0,"95.709",1252100000,76,"0.0523475",1,"0.0606766","0.152134","tr|C9JFE4|C9JFE4_HUMAN;sp|Q13098|CSN1_HUMAN;tr|A0A096LP07|A0A096LP07_HUMAN;tr|A0A096LPJ3|A0A096LPJ3_HUMAN;tr|A8K070|A8K070_HUMAN;tr|J3KSA5|J3KSA5_HUMAN;tr|J3QLT0|J3QLT0_HUMAN;tr|J3KRJ4|J3KRJ4_HUMAN;tr|J3QS88|J3QS88_HUMAN;tr|J3KTB0|J3KTB0_HUMAN;tr|J3QQX0|J3QQX0_HUMAN;tr|J3QS84|J3QS84_HUMAN;tr|J3QLE8|J3QLE8_HUMAN;tr|J3QL53|J3QL53_HUMAN;tr|J3KRE8|J3KRE8_HUMAN","tr|C9JFE4|C9JFE4_HUMAN;sp|Q13098|CSN1_HUMAN;tr|A0A096LP07|A0A096LP07_HUMAN;tr|A0A096LPJ3|A0A096LPJ3_HUMAN;tr|A8K070|A8K070_HUMAN",2304,"C9JFE4","C9JFE4_HUMAN"]
["15.1472","15.5924","15.852","15.0979","15.5896","15.7265",{"$nulls":3},"negative regulation of vascular smooth muscle contraction;positive regulation of epithelial cell migration;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of vascular associated smooth muscle cell migration;small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity","cytoplasm;cytosol;plasma membrane",{"$nulls":3},12,11,11,"7.9","7.4","7.4","215.31",0,"16.839",169450000,14,"0.0740606",1,"0.0592152","0.210978","sp|Q9H7D0|DOCK5_HUMAN;tr|H0Y7N4|H0Y7N4_HUMAN;tr|H0YB14|H0YB14_HUMAN","sp|Q9H7D0|DOCK5_HUMAN;tr|H0Y7N4|H0Y7N4_HUMAN",4504,"Q9H7D0","DOCK5_HUMAN","Dedicator of cytokinesis protein 5",null,"DOCK5"]
["23.6031","23.8559","24.2763","23.5621","23.7333","24.2646",{"$nulls":3},"translational initiation","RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytosol",{"$nulls":3},5,5,5,50,50,50,"16.46",0,"31.376",1054200000,25,"0.0708316",1,"0.0583992","0.202362","sp|P47813|IF1AX_HUMAN;sp|O14602|IF1AY_HUMAN;tr|X6RAC9|X6RAC9_HUMAN;tr|A6NJH9|A6NJH9_HUMAN","sp|P47813|IF1AX_HUMAN;sp|O14602|IF1AY_HUMAN;tr|X6RAC9|X6RAC9_HUMAN;tr|A6NJH9|A6NJH9_HUMAN",274,"P47813","IF1AX_HUMAN","Eukaryotic translation initiation factor 1A, X-chromosomal","IF-1A X isoform","EIF1AX"]
["22.0778","21.0611","21.1462","21.9512","20.8855","21.2735",{"$nulls":3},"negative regulation of transcription elongation from RNA polymerase II promoter;positive regulation of viral transcription;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","RNA binding","cytoplasm;NELF complex;nucleoplasm",{"$nulls":3},11,11,11,"29.5","29.5","29.5","65.697",0,"137.31",711920000,48,"0.044174",1,"0.0583038","0.129399","sp|Q8WX92|NELFB_HUMAN","sp|Q8WX92|NELFB_HUMAN",3640,"Q8WX92","NELFB_HUMAN","Negative elongation factor B","ELF-B","NELFB"]
["24.9985","21.4907","23.9877","24.7988","21.5976","23.9104",{"$nulls":3},"cellular protein metabolic process;post-translational protein modification","calcium ion binding","endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular region;Golgi apparatus;melanosome;membrane;sarcoplasmic reticulum lumen",{"$nulls":3},16,16,16,60,60,60,"37.106",0,"323.31",2440500000,98,"0.0132679",1,"0.0567125","0.0401314","sp|O43852|CALU_HUMAN;tr|H0Y875|H0Y875_HUMAN","sp|O43852|CALU_HUMAN;tr|H0Y875|H0Y875_HUMAN",468,"O43852","CALU_HUMAN","Calumenin",null,"CALU"]
["23.4458","23.0775","23.9056","23.447","22.8449","23.9717",{"$nulls":3},"exon-exon junction complex disassembly;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of translation","ribosome binding;RNA binding","cell junction;cytosol;exon-exon junction complex;nucleolus;nucleoplasm;nucleus","mRNA surveillance pathway;RNA transport",null,null,8,8,8,"53.4","53.4","53.4","22.655",0,"113.89",1456000000,73,"0.0466971",1,"0.0551523","0.136454","sp|Q9BRP8|WIBG_HUMAN","sp|Q9BRP8|WIBG_HUMAN",4166,"Q9BRP8","PYM1_HUMAN","Partner of Y14 and mago {ECO:0000250|UniProtKB:P82804}",null,"PYM1"]
["26.4217","23.6495","25.335","26.4283","23.4777","25.3375",{"$nulls":3},"in utero embryonic development;protein transport;regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter","RNA binding","cytosol;nucleus",{"$nulls":3},11,11,11,"71.4","71.4","71.4","22.168",0,"323.31",7667900000,321,"0.0152301",1,"0.0542405","0.045968","sp|P20290|BTF3_HUMAN;tr|D6RDG3|D6RDG3_HUMAN;tr|H0Y9Y1|H0Y9Y1_HUMAN","sp|P20290|BTF3_HUMAN",1207,"P20290","BTF3_HUMAN","Transcription factor BTF3",null,"BTF3"]
["18.6921","19.0735","17.2148","19.0376","18.289","17.4915",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitinyl hydrolase activity;zinc ion binding","Flemming body;nucleoplasm",{"$nulls":3},5,5,5,"12.7","12.7","12.7","56.648",0,"14.186",106470000,16,"0.025126",1,"0.0541375","0.0750386","tr|Q6JHV3|Q6JHV3_HUMAN;tr|H0YMI4|H0YMI4_HUMAN;sp|Q9Y6I4|UBP3_HUMAN;tr|H0YLB7|H0YLB7_HUMAN;tr|H0YKU8|H0YKU8_HUMAN;tr|H0YL81|H0YL81_HUMAN;tr|H0YM72|H0YM72_HUMAN;tr|H0YMP6|H0YMP6_HUMAN;tr|H0YLG0|H0YLG0_HUMAN","tr|Q6JHV3|Q6JHV3_HUMAN;tr|H0YMI4|H0YMI4_HUMAN;sp|Q9Y6I4|UBP3_HUMAN;tr|H0YLB7|H0YLB7_HUMAN;tr|H0YKU8|H0YKU8_HUMAN",5410,"Q6JHV3","Q6JHV3_HUMAN","Ubiquitinyl hydrolase 1 {ECO:0000256|SAAS:SAAS00003083}",null,"USP3"]
["18.3927","17.6376","19.6593","18.0259","17.3167","20.1865",{"$nulls":3},"defense response to virus;DNA deamination;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;nuclear mRNA surveillance;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';polyadenylation-dependent snoRNA 3'-end processing;regulation of mRNA stability;rRNA 3'-end processing;rRNA catabolic process;rRNA processing;U4 snRNA 3'-end processing","3'-5'-exoribonuclease activity;RNA binding","cytoplasm;cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);nuclear exosome (RNase complex);nucleolus;nucleoplasm;nucleus;transcriptionally active chromatin","RNA degradation",null,null,3,3,3,"13.2","13.2","13.2","25.249",0,"8.6711",47528000,4,"0.0169789",1,"0.0534681","0.0511492","sp|Q9NQT4|EXOS5_HUMAN;tr|M0R050|M0R050_HUMAN;tr|M0R102|M0R102_HUMAN","sp|Q9NQT4|EXOS5_HUMAN;tr|M0R050|M0R050_HUMAN",4661,"Q9NQT4","EXOS5_HUMAN","Exosome complex component RRP46",null,"EXOSC5"]
["22.4273","21.6929","22.6728","23.3704","20.8849","22.3813",{"$nulls":3},"actin cytoskeleton reorganization;cell cycle;cell division;chemotaxis;exocytosis;interleukin-12-mediated signaling pathway;membrane organization;membrane raft localization;neural tube closure;positive regulation of filopodium assembly;Ras protein signal transduction;regulation of exocytosis;signal transduction;viral process","ATPase binding;Edg-2 lysophosphatidic acid receptor binding;GDP binding;GTP binding;GTPase activity;myosin binding;ubiquitin protein ligase binding","cell surface;cleavage furrow;cytoplasmic vesicle membrane;extracellular exosome;Flemming body;focal adhesion;myelin sheath;plasma membrane","Colorectal cancer;Pancreatic cancer;Pathways in cancer;Phospholipase D signaling pathway;Rap1 signaling pathway;Ras signaling pathway",null,null,9,9,5,50,50,"19.4","23.567",0,"100.93",732600000,66,"0.022314",1,"0.0521418","0.0668384","sp|P11233|RALA_HUMAN;tr|H7C3P7|H7C3P7_HUMAN;tr|C9JPE8|C9JPE8_HUMAN;tr|C9JYR1|C9JYR1_HUMAN;tr|F8WEQ6|F8WEQ6_HUMAN","sp|P11233|RALA_HUMAN;tr|H7C3P7|H7C3P7_HUMAN",1042,"P11233","RALA_HUMAN","Ras-related protein Ral-A",null,"RALA"]
["23.6184","21.4438","23.1093","23.7945","21.0405","23.1836",{"$nulls":3},"DNA replication;DNA replication initiation;G1/S transition of mitotic cell cycle","ATP binding;chromatin binding;DNA helicase activity;DNA replication origin binding","cytosol;MCM complex;membrane;nuclear chromosome, telomeric region;nucleoplasm;nucleus","Cell cycle;DNA replication",null,null,31,31,31,"51.4","51.4","51.4","82.285",0,"318.63",3494600000,192,"0.0159073",1,"0.0509663","0.0479767","sp|P33992|MCM5_HUMAN;tr|B1AHB1|B1AHB1_HUMAN;tr|B1AHA9|B1AHA9_HUMAN;tr|B1AHB2|B1AHB2_HUMAN;tr|F8WFD7|F8WFD7_HUMAN","sp|P33992|MCM5_HUMAN;tr|B1AHB1|B1AHB1_HUMAN",1438,"P33992","MCM5_HUMAN","DNA replication licensing factor MCM5",null,"MCM5"]
["22.6174","21.2333","22.0879","22.6435","21.0171","22.1253",{"$nulls":3},"post-translational protein modification","metal ion binding","endoplasmic reticulum;endoplasmic reticulum lumen",{"$nulls":3},6,6,6,"21.9","21.9","21.9","33.843",0,"30.848",535130000,44,"0.0272544",1,"0.0508912","0.081214","sp|Q8NBJ7|SUMF2_HUMAN;tr|A8MXB9|A8MXB9_HUMAN;tr|J3KQJ1|J3KQJ1_HUMAN;tr|C9JL30|C9JL30_HUMAN;tr|H7C3B2|H7C3B2_HUMAN;tr|C9J660|C9J660_HUMAN;tr|E9PBT8|E9PBT8_HUMAN;tr|J3QT17|J3QT17_HUMAN;tr|F8WA42|F8WA42_HUMAN;tr|F8WEV7|F8WEV7_HUMAN;tr|F8WES7|F8WES7_HUMAN;tr|F8WEX5|F8WEX5_HUMAN;tr|E9PG02|E9PG02_HUMAN","sp|Q8NBJ7|SUMF2_HUMAN;tr|A8MXB9|A8MXB9_HUMAN;tr|J3KQJ1|J3KQJ1_HUMAN;tr|C9JL30|C9JL30_HUMAN;tr|H7C3B2|H7C3B2_HUMAN;tr|C9J660|C9J660_HUMAN;tr|E9PBT8|E9PBT8_HUMAN;tr|J3QT17|J3QT17_HUMAN;tr|F8WA42|F8WA42_HUMAN",3455,"Q8NBJ7","SUMF2_HUMAN","Sulfatase-modifying factor 2",null,"SUMF2"]
["17.2103","15.9586","16.8454","17.3473","15.7242","16.7979",{"$nulls":4},"histone-lysine N-methyltransferase activity;zinc ion binding","chromosome;nucleus",{"$nulls":3},2,2,2,"3.6","3.6","3.6","129.03",0,"24.002",91013000,13,"0.0267898",1,"0.0482731","0.0798684","tr|A0A0G2JIS2|A0A0G2JIS2_HUMAN;sp|Q96KQ7|EHMT2_HUMAN;tr|A2ABF8|A2ABF8_HUMAN;tr|A0A0G2JIR1|A0A0G2JIR1_HUMAN;tr|A2ABF9|A2ABF9_HUMAN;tr|A0A0G2JK64|A0A0G2JK64_HUMAN","tr|A0A0G2JIS2|A0A0G2JIS2_HUMAN;sp|Q96KQ7|EHMT2_HUMAN;tr|A2ABF8|A2ABF8_HUMAN;tr|A0A0G2JIR1|A0A0G2JIR1_HUMAN;tr|A2ABF9|A2ABF9_HUMAN;tr|A0A0G2JK64|A0A0G2JK64_HUMAN",3962,"A0A0G2JIS2","A0A0G2JIS2_HUMAN",null,null,"EHMT2"]
["18.6204","17.7898","18.4873","18.0151","18.1421","18.5974",{"$nulls":3},"cell cycle",null,"cytoplasm;membrane",{"$nulls":3},4,3,3,"19.8","14.8","14.8","39.416",0,"13.44",74057000,5,"0.0524609",1,"0.0476233","0.152447","sp|Q9BRP1|PDD2L_HUMAN;tr|U3KQA4|U3KQA4_HUMAN","sp|Q9BRP1|PDD2L_HUMAN",4165,"Q9BRP1","PDD2L_HUMAN","Programmed cell death protein 2-like",null,"PDCD2L"]
["20.577","19.7038","20.1239","21.0163","19.514","19.7339",{"$nulls":3},"protein K69-linked ufmylation;protein ufmylation;regulation of intracellular estrogen receptor signaling pathway;response to endoplasmic reticulum stress","ATP binding;metal ion binding;UFM1 activating enzyme activity","cytoplasm;cytosol;intracellular membrane-bounded organelle;nucleus",{"$nulls":3},9,9,9,"32.7","32.7","32.7","44.863",0,"20.062",235770000,18,"0.029613",1,"0.046828","0.0880266","sp|Q9GZZ9|UBA5_HUMAN;tr|E7EQ61|E7EQ61_HUMAN;tr|E7EWE1|E7EWE1_HUMAN;tr|C9J0F6|C9J0F6_HUMAN;tr|C9J5W5|C9J5W5_HUMAN;tr|C9JRV9|C9JRV9_HUMAN;tr|D6RJC9|D6RJC9_HUMAN","sp|Q9GZZ9|UBA5_HUMAN;tr|E7EQ61|E7EQ61_HUMAN;tr|E7EWE1|E7EWE1_HUMAN",4373,"Q9GZZ9","UBA5_HUMAN","Ubiquitin-like modifier-activating enzyme 5","biquitin-activating enzyme 5","UBA5"]
["25.2129","24.997","25.139","25.5213","24.6053","25.0846",{"$nulls":4},"RNA binding","mitochondrion",{"$nulls":3},6,6,6,"65.2","65.2","65.2","10.353",0,"104.21",2588100000,85,"0.0583942",1,"0.0458965","0.16874","tr|A0A087WUN7|A0A087WUN7_HUMAN;tr|H0YJ40|H0YJ40_HUMAN;tr|G3V4X6|G3V4X6_HUMAN;sp|Q9GZT3|SLIRP_HUMAN;tr|G3V2S9|G3V2S9_HUMAN;tr|H0YJW7|H0YJW7_HUMAN;tr|H0YJ07|H0YJ07_HUMAN;tr|H0YJU7|H0YJU7_HUMAN;tr|H0YJI1|H0YJI1_HUMAN","tr|A0A087WUN7|A0A087WUN7_HUMAN;tr|H0YJ40|H0YJ40_HUMAN;tr|G3V4X6|G3V4X6_HUMAN;sp|Q9GZT3|SLIRP_HUMAN;tr|G3V2S9|G3V2S9_HUMAN;tr|H0YJW7|H0YJW7_HUMAN;tr|H0YJ07|H0YJ07_HUMAN;tr|H0YJU7|H0YJU7_HUMAN",4368,"A0A087WUN7","A0A087WUN7_HUMAN",null,null,"SLIRP"]
["25.1509","23.9286","24.6655","25.2504","23.8868","24.471",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","cadherin binding;endopeptidase activity;threonine-type endopeptidase activity","cytosol;extracellular exosome;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex","Proteasome",null,null,5,5,5,"36.4","36.4","36.4","25.357",0,"283.16",2723900000,39,"0.0288561",1,"0.0456085","0.0858439","sp|P28072|PSB6_HUMAN;tr|A0A087X2I4|A0A087X2I4_HUMAN;tr|I3L3X7|I3L3X7_HUMAN","sp|P28072|PSB6_HUMAN",1335,"P28072","PSB6_HUMAN","Proteasome subunit beta type-6",null,"PSMB6"]
["23.687","22.3085","23.5305","23.5475","22.402","23.4414",{"$nulls":3},"cytoplasmic mRNA processing body assembly;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;negative regulation of neuron differentiation;regulation of translation;RNA secondary structure unwinding;spermatogenesis;stem cell population maintenance;viral RNA genome packaging","ATP binding;ATP-dependent RNA helicase activity;cadherin binding;helicase activity;protein domain specific binding;RNA binding;RNA helicase activity","cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;heterochromatin;membrane;mitochondrion;nucleolus;nucleus;outer dense fiber;P granule;P-body;RISC complex;sperm annulus","RNA degradation",null,null,19,19,19,"53.4","53.4","53.4","54.416",0,"323.31",2733900000,149,"0.0265626",1,"0.0450478","0.0792096","sp|P26196|DDX6_HUMAN;tr|Q8IV96|Q8IV96_HUMAN","sp|P26196|DDX6_HUMAN",1302,"P26196","DDX6_HUMAN","Probable ATP-dependent RNA helicase DDX6 {ECO:0000305}",null,"DDX6"]
["19.0756","17.6328","18.8428","19.3982","17.4124","18.6107",{"$nulls":3},"cargo loading into COPII-coated vesicle;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;exocytosis;lipoprotein transport;negative regulation of cell adhesion;negative regulation of cell migration;positive regulation of leukocyte migration;post-translational protein modification;protein transport;wound healing","lipoprotein transporter activity","endoplasmic reticulum exit site;endoplasmic reticulum lumen;endoplasmic reticulum membrane;Golgi membrane;integral component of membrane;membrane",{"$nulls":3},24,24,24,"18.2","18.2","18.2","213.7",0,"87.282",467650000,62,"0.0197619",1,"0.0433458","0.0593552","sp|Q5JRA6|MIA3_HUMAN;tr|A0A0A0MRH6|A0A0A0MRH6_HUMAN","sp|Q5JRA6|MIA3_HUMAN;tr|A0A0A0MRH6|A0A0A0MRH6_HUMAN",2821,"Q5JRA6","TGO1_HUMAN","Transport and Golgi organization protein 1 homolog {ECO:0000305}","ANGO1 {ECO:0000303|PubMed:19269366}","MIA3"]
["18.7714","17.1418","18.7223","18.3478","17.2565","18.903",{"$nulls":3},"cytidine deamination;defense response to virus;DNA demethylation;innate immune response;negative regulation of transposition;negative regulation of viral genome replication;viral process","hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;RNA binding;zinc ion binding","cytoplasm;nucleus","Human immunodeficiency virus 1 infection",null,null,4,4,3,"29.5","29.5","23.2","22.826",0,"10.157",42194000,7,"0.019727",1,"0.0427411","0.0592526","sp|Q9NRW3|ABC3C_HUMAN;tr|A0A087WX48|A0A087WX48_HUMAN;tr|Q6ICH2|Q6ICH2_HUMAN;sp|Q96AK3|ABC3D_HUMAN","sp|Q9NRW3|ABC3C_HUMAN",4699,"Q9NRW3","ABC3C_HUMAN","DNA dC->dU-editing enzyme APOBEC-3C","3C","APOBEC3C"]
["21.1801","18.7928","21.205","20.7945","19.3575","20.8979",{"$nulls":3},"glycogen biosynthetic process;glycogen catabolic process;neutrophil degranulation","glycogenin glucosyltransferase activity;metal ion binding;UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;lysosomal lumen;membrane;secretory granule lumen","Metabolic pathways;Starch and sucrose metabolism",null,null,6,6,6,"20.3","20.3","20.3","39.383",0,"83.835",209680000,17,"0.0150055",1,"0.0426661","0.0453011","sp|P46976|GLYG_HUMAN;tr|G5E9W8|G5E9W8_HUMAN;tr|C9JQ42|C9JQ42_HUMAN;tr|C9J8R8|C9J8R8_HUMAN;tr|C9J7C7|C9J7C7_HUMAN","sp|P46976|GLYG_HUMAN;tr|G5E9W8|G5E9W8_HUMAN;tr|C9JQ42|C9JQ42_HUMAN",1608,"P46976","GLYG_HUMAN","Glycogenin-1","N1;N-1","GYG1"]
["22.7488","21.6379","22.5345","22.5329","21.5648","22.7012",{"$nulls":3},"apoptotic process;cell differentiation;muscle organ development;negative regulation of translation;positive regulation of gene silencing by miRNA","G-quadruplex RNA binding;mRNA 3'-UTR binding;mRNA binding;protein heterodimerization activity;protein homodimerization activity;RNA binding;RNA strand annealing activity","axon;costamere;cytoplasm;cytosol;dendritic spine;membrane;nucleolus;perinuclear region of cytoplasm;polysome;ribonucleoprotein granule","RNA transport",null,null,24,24,22,"45.1","45.1","42.5","69.72",0,"232.99",1781200000,124,"0.0278695",1,"0.0407556","0.0829939","sp|P51114|FXR1_HUMAN;tr|B4DXZ6|B4DXZ6_HUMAN;tr|E9PFF5|E9PFF5_HUMAN;tr|E7EU85|E7EU85_HUMAN;tr|H7C4S4|H7C4S4_HUMAN;tr|C9JZE0|C9JZE0_HUMAN;tr|C9JY20|C9JY20_HUMAN;tr|C9JAJ4|C9JAJ4_HUMAN;tr|C9JYQ6|C9JYQ6_HUMAN;tr|C9IZ22|C9IZ22_HUMAN","sp|P51114|FXR1_HUMAN;tr|B4DXZ6|B4DXZ6_HUMAN;tr|E9PFF5|E9PFF5_HUMAN;tr|E7EU85|E7EU85_HUMAN",1728,"P51114","FXR1_HUMAN","Fragile X mental retardation syndrome-related protein 1","FXR1p","FXR1"]
["21.2171","18.9773","19.2779","21.4516","18.684","19.2163",{"$nulls":3},"mRNA splicing, via spliceosome;negative regulation of phosphatase activity;spliceosomal tri-snRNP complex assembly","ribonucleoprotein complex binding","cytoplasm;cytosol;fibrillar center;nuclear speck;nucleoplasm;nucleus;U5 snRNP",{"$nulls":3},6,6,6,"26.4","26.4","26.4","37.646",0,"56.39",291530000,33,"0.0120364",1,"0.0401262","0.0364557","sp|O95400|CD2B2_HUMAN","sp|O95400|CD2B2_HUMAN",753,"O95400","CD2B2_HUMAN","CD2 antigen cytoplasmic tail-binding protein 2","D2 cytoplasmic domain-binding protein 2;D2 tail-binding protein 2","CD2BP2"]
["17.3535","16.6929","16.3091","16.3405","16.0746","17.8219",{"$nulls":3},"DNA-templated transcription, initiation;negative regulation of cell cycle;negative regulation of cell proliferation;regulation of DNA binding transcription factor activity;regulation of signal transduction by p53 class mediator;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","aryl hydrocarbon receptor binding;DNA binding;DNA binding transcription factor activity;protein heterodimerization activity","cytosol;MLL1 complex;nucleoplasm;nucleus;protein complex;transcription factor TFIID complex;transcription factor TFTC complex","Basal transcription factors",null,null,16,16,16,"32.9","32.9","32.9","72.668",0,"90.907",497060000,70,"0.0211289",1,"0.0394967","0.0633685","sp|P49848|TAF6_HUMAN;tr|J3KR72|J3KR72_HUMAN;tr|C9JFL8|C9JFL8_HUMAN;tr|C9JTY6|C9JTY6_HUMAN;tr|C9JIS2|C9JIS2_HUMAN;tr|E5RHA1|E5RHA1_HUMAN;tr|C9J088|C9J088_HUMAN;tr|E5RKA5|E5RKA5_HUMAN;tr|F8WEJ7|F8WEJ7_HUMAN;tr|C9J7C4|C9J7C4_HUMAN;tr|C9JHQ8|C9JHQ8_HUMAN","sp|P49848|TAF6_HUMAN;tr|J3KR72|J3KR72_HUMAN",1691,"P49848","TAF6_HUMAN","Transcription initiation factor TFIID subunit 6",null,"TAF6"]
["15.962","15.2748",1,"15.8327","15.2889",1,{"$nulls":3},"mRNA splicing, via spliceosome;protein phosphorylation;RNA splicing","ATP binding;protein kinase activity;protein serine/threonine kinase activity;RNA binding","catalytic step 2 spliceosome;chromosome;nuclear speck",{"$nulls":3},13,13,13,"15.4","15.4","15.4","116.99",0,"37.076",113670000,20,"0.00182192",1,"0.0384156","0.00558182","sp|Q13523|PRP4B_HUMAN;tr|H0YDJ3|H0YDJ3_HUMAN","sp|Q13523|PRP4B_HUMAN;tr|H0YDJ3|H0YDJ3_HUMAN",2374,"Q13523","PRP4B_HUMAN","Serine/threonine-protein kinase PRP4 homolog",null,"PRPF4B"]
["23.712","17.2942","22.0438","21.278","20.3395","21.3225",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","RNA binding","mitochondrial inner membrane;mitochondrial large ribosomal subunit",{"$nulls":3},3,3,3,"48.6","48.6","48.6","15.819",0,"36.52",229650000,27,"0.00617019",1,"0.0366631","0.0188107","sp|Q6P161|RM54_HUMAN","sp|Q6P161|RM54_HUMAN",2994,"Q6P161","RM54_HUMAN","39S ribosomal protein L54, mitochondrial","54mt;RP-L54","MRPL54"]
["23.5221","21.6792","23.0657","23.5246","21.6778","22.9597",{"$nulls":3},"carnitine biosynthetic process;carnitine metabolic process, CoA-linked;fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA dehydrogenase;medium-chain fatty acid catabolic process;medium-chain fatty acid metabolic process;oxidation-reduction process;regulation of lipid metabolic process","acyl-CoA dehydrogenase activity;flavin adenine dinucleotide binding;identical protein binding;medium-chain-acyl-CoA dehydrogenase activity","axon;extracellular exosome;mitochondrial matrix;mitochondrial membrane;mitochondrion;nuclear speck;nucleus","Fatty acid degradation;Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway;Valine, leucine and isoleucine degradation",null,null,16,16,16,"46.6","46.6","46.6","46.588",0,"223.49",1422200000,82,"0.0148848",1,"0.0349725","0.0449425","sp|P11310|ACADM_HUMAN;tr|Q5T4U5|Q5T4U5_HUMAN;tr|B7Z9I1|B7Z9I1_HUMAN;tr|E9PJM9|E9PJM9_HUMAN;tr|E9PRX4|E9PRX4_HUMAN;tr|H0YDT5|H0YDT5_HUMAN","sp|P11310|ACADM_HUMAN;tr|Q5T4U5|Q5T4U5_HUMAN;tr|B7Z9I1|B7Z9I1_HUMAN",1045,"P11310","ACADM_HUMAN","Medium-chain specific acyl-CoA dehydrogenase, mitochondrial","CAD","ACADM"]
[1,"16.1413","18.1861",1,"16.2113","18.0126",{"$nulls":9},2,2,2,"16.7","16.7","16.7","22.49",0,"6.2229",14504000,5,"0.00147069",1,"0.0344741","0.00450758","tr|K7ER15|K7ER15_HUMAN;sp|Q9H0R4|HDHD2_HUMAN;tr|K7EMY7|K7EMY7_HUMAN","tr|K7ER15|K7ER15_HUMAN;sp|Q9H0R4|HDHD2_HUMAN;tr|K7EMY7|K7EMY7_HUMAN",4396,"K7ER15","K7ER15_HUMAN",null,null,"HDHD2"]
["19.0312","17.1377","18.5703","18.8687","17.0094","18.7592",{"$nulls":3},"animal organ regeneration;liver development;mRNA export from nucleus;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay","RNA binding;telomeric DNA binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;exon-exon junction complex;nucleus;perinuclear region of cytoplasm;polysome","mRNA surveillance pathway;RNA transport",null,null,30,30,30,"28.8","28.8","28.8","147.81",0,215,1488000000,127,"0.0135555",1,"0.0339934","0.0409886","sp|Q9HAU5|RENT2_HUMAN","sp|Q9HAU5|RENT2_HUMAN",4561,"Q9HAU5","RENT2_HUMAN","Regulator of nonsense transcripts 2",null,"UPF2"]
["19.8254","19.0626","20.1674","20.153","18.4478","20.3546",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;cell cycle;cell division;dopamine receptor signaling pathway;G-protein coupled receptor signaling pathway;GTP metabolic process;negative regulation of adenylate cyclase activity;positive regulation of macroautophagy;protein folding;transport;vesicle fusion","GDP binding;G-protein beta/gamma-subunit complex binding;G-protein coupled receptor binding;G-protein coupled serotonin receptor binding;GTP binding;GTPase activating protein binding;GTPase activity;metal ion binding;protein domain specific binding;signal transducer activity","centrosome;cytoplasm;extracellular exosome;Golgi apparatus;heterotrimeric G-protein complex;lysosomal membrane;membrane;membrane raft;midbody;nucleolus;nucleus;plasma membrane;zymogen granule","Adrenergic signaling in cardiomyocytes;Alcoholism;Apelin signaling pathway;Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Leukocyte transendothelial migration;Long-term depression;Melanogenesis;Morphine addiction;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Serotonergic synapse;Sphingolipid signaling pathway;Toxoplasmosis",null,null,10,5,5,"31.1","16.1","16.1","40.532",0,"13.967",161790000,15,"0.016096",1,"0.0333602","0.0485358","sp|P08754|GNAI3_HUMAN","sp|P08754|GNAI3_HUMAN",974,"P08754","GNAI3_HUMAN","Guanine nucleotide-binding protein G(k) subunit alpha {ECO:0000303|PubMed:2452165}",null,"GNAI3"]
["26.1297","24.1141","26.0182","26.4226","23.9304","25.8113",{"$nulls":3},"regulation of microtubule polymerization or depolymerization",{"$nulls":5},7,7,5,"69.4","69.4","49.4","9.7931",0,"75.806",3235900000,90,"0.0107809",1,"0.0325375","0.0326983","tr|A2A2D0|A2A2D0_HUMAN;sp|P16949|STMN1_HUMAN","tr|A2A2D0|A2A2D0_HUMAN;sp|P16949|STMN1_HUMAN",1141,"A2A2D0","A2A2D0_HUMAN","Stathmin {ECO:0000256|RuleBase:RU004388}",null,"STMN1"]
["25.9446","25.1262","25.4352","25.9073","24.9258","25.5775",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of cell cycle;positive regulation of cell proliferation;response to virus;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;membrane;mitochondrion;nucleoplasm","Ribosome",null,null,12,12,5,"69.2","69.2","36.9","14.839",0,"192.99",21202000000,767,"0.028536",1,"0.0317841","0.0849199","sp|P62244|RS15A_HUMAN;tr|I3L3P7|I3L3P7_HUMAN;tr|I3L246|I3L246_HUMAN;tr|H3BV27|H3BV27_HUMAN;tr|H3BT37|H3BT37_HUMAN;tr|I3L303|I3L303_HUMAN;tr|H3BVC7|H3BVC7_HUMAN","sp|P62244|RS15A_HUMAN;tr|I3L3P7|I3L3P7_HUMAN;tr|I3L246|I3L246_HUMAN",1960,"P62244","RS15A_HUMAN","40S ribosomal protein S15a",null,"RPS15A"]
["18.3547","17.6899","17.9127","18.7851","17.1144","17.9752",{"$nulls":3},"cell death;cellular protein modification process;cellular response to DNA damage stimulus;DNA repair;inflammatory response;protein ADP-ribosylation;regulation of telomerase activity;response to drug","DNA binding;enzyme binding;NAD+ ADP-ribosyltransferase activity","cytoplasm;cytosol;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleus;spindle microtubule","Apoptosis;Base excision repair;Necroptosis",null,null,10,10,10,"6.3","6.3","6.3","192.59",0,"27.627",233680000,23,"0.0175908",1,"0.0275599","0.0529574","sp|Q9UKK3|PARP4_HUMAN","sp|Q9UKK3|PARP4_HUMAN",5091,"Q9UKK3","PARP4_HUMAN","Poly [ADP-ribose] polymerase 4","ARP-4","PARP4"]
["24.8538","24.5243","24.2853","25.05","24.1294","24.4048",{"$nulls":3},"cell proliferation;DNA double-strand break processing;double-strand break repair via nonhomologous end joining;error-free postreplication DNA repair;global genome nucleotide-excision repair;negative regulation of neuron apoptotic process;positive regulation of DNA repair;positive regulation of neuron projection development;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of synapse assembly;postreplication repair;protein K63-linked ubiquitination;protein polyubiquitination;protein ubiquitination;regulation of DNA repair","ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding","cytoplasm;extracellular exosome;nucleoplasm;nucleus;UBC13-MMS2 complex",{"$nulls":3},9,9,4,69,69,"30.3","16.363",0,"53.551",2363800000,67,"0.0278415",1,"0.026425","0.0829128","sp|Q15819|UB2V2_HUMAN;tr|G3V113|G3V113_HUMAN;tr|H0YBP9|H0YBP9_HUMAN;tr|H0YBX6|H0YBX6_HUMAN","sp|Q15819|UB2V2_HUMAN;tr|G3V113|G3V113_HUMAN;tr|H0YBP9|H0YBP9_HUMAN",2648,"Q15819","UB2V2_HUMAN","Ubiquitin-conjugating enzyme E2 variant 2",null,"UBE2V2"]
["21.5667","18.7096","21.5851","20.901","19.2622","21.6217",{"$nulls":3},"arginyl-tRNA aminoacylation","arginine-tRNA ligase activity;ATP binding","cytoplasm","Spliceosome",null,null,4,4,4,"34.3","34.3","34.3","19.181",0,"28.911",160590000,14,"0.0070705",1,"0.0254809","0.0215336","sp|Q8WUD4|CCD12_HUMAN;tr|J3KR35|J3KR35_HUMAN;tr|S4R331|S4R331_HUMAN;tr|C9JUN5|C9JUN5_HUMAN","sp|Q8WUD4|CCD12_HUMAN;tr|J3KR35|J3KR35_HUMAN",3599,"Q8WUD4","CCD12_HUMAN","Coiled-coil domain-containing protein 12",null,"CCDC12"]
["19.3364","18.5078","17.8229","19.4896","18.3842","17.7169",{"$nulls":3},"cell proliferation;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;gene silencing by RNA;nuclear-transcribed mRNA poly(A) tail shortening;regulation of transcription, DNA-templated;regulation of translation;transcription, DNA-templated",null,"CCR4-NOT complex;cytosol;nucleus",{"$nulls":3},5,5,5,"15.7","15.7","15.7","55.215",0,"25.041",115320000,22,"0.0124134",1,"0.0254523","0.0375821","sp|Q9UKZ1|CNO11_HUMAN;tr|H7C0C7|H7C0C7_HUMAN","sp|Q9UKZ1|CNO11_HUMAN;tr|H7C0C7|H7C0C7_HUMAN",5104,"Q9UKZ1","CNO11_HUMAN","CCR4-NOT transcription complex subunit 11",null,"CNOT11"]
["21.439","16.6434","19.1519","21.8232","16.5615","18.7758",{"$nulls":3},"protein prenylation","protein prenyltransferase activity",{"$nulls":4},8,8,8,"44.2","44.2","44.2","30.079",0,"80.971",137970000,13,"0.0039098",1,"0.0246188","0.01195","tr|E9PQP6|E9PQP6_HUMAN;sp|P49354|FNTA_HUMAN;tr|B3KVN2|B3KVN2_HUMAN;tr|H0YCW1|H0YCW1_HUMAN;tr|E9PPM9|E9PPM9_HUMAN;tr|E9PN85|E9PN85_HUMAN","tr|E9PQP6|E9PQP6_HUMAN;sp|P49354|FNTA_HUMAN;tr|B3KVN2|B3KVN2_HUMAN;tr|H0YCW1|H0YCW1_HUMAN",1652,"E9PQP6","E9PQP6_HUMAN",null,null,"FNTA"]
["23.9186","23.4695","23.8906","23.826","23.6204","23.7621",{"$nulls":3},"cellular response to interferon-gamma;glutamyl-tRNA aminoacylation;negative regulation of translation;prolyl-tRNA aminoacylation;protein complex assembly;tRNA aminoacylation for protein translation","ATP binding;glutamate-tRNA ligase activity;GTPase binding;identical protein binding;proline-tRNA ligase activity;protein homodimerization activity;RNA stem-loop binding;zinc ion binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;GAIT complex;intracellular ribonucleoprotein complex;membrane","Aminoacyl-tRNA biosynthesis;Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,81,81,80,60,60,"59.5","170.59",0,"323.31",24672000000,1103,"0.0510374",1,"0.0233841","0.148512","sp|P07814|SYEP_HUMAN;tr|V9GYZ6|V9GYZ6_HUMAN;tr|V9GZ76|V9GZ76_HUMAN","sp|P07814|SYEP_HUMAN;tr|V9GYZ6|V9GYZ6_HUMAN",944,"P07814","SYEP_HUMAN","Bifunctional glutamate/proline--tRNA ligase",null,"EPRS"]
["19.7363","19.6255","19.9141","19.6887","19.2686","20.2501",{"$nulls":3},"tRNA 5'-leader removal;tRNA catabolic process;tRNA processing","ribonuclease MRP activity;ribonuclease P activity;RNA binding","extracellular space;Golgi apparatus;intracellular membrane-bounded organelle;mitochondrion;multimeric ribonuclease P complex;nucleolar ribonuclease P complex;nucleolus;nucleoplasm;ribonuclease MRP complex","Ribosome biogenesis in eukaryotes;RNA transport",null,null,18,18,18,27,27,27,"114.71",0,"163.23",1156300000,104,"0.0257808",1,"0.0228125","0.0769412","sp|Q99575|POP1_HUMAN;tr|E5RK39|E5RK39_HUMAN","sp|Q99575|POP1_HUMAN",4082,"Q99575","POP1_HUMAN","Ribonucleases P/MRP protein subunit POP1","POP1","POP1"]
["20.0447","16.9431","18.4167","20.0671","16.9122","18.3574",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process;positive regulation of apoptotic process;positive regulation of hematopoietic stem cell proliferation;regulation of hematopoietic progenitor cell differentiation","DNA binding;enzyme binding;metal ion binding","cytoplasm;extracellular exosome;nucleus",{"$nulls":3},5,5,5,"23.3","23.3","23.3","38.592",0,"41.222",258450000,32,"0.00580276",1,"0.0226212","0.0176978","sp|Q16342|PDCD2_HUMAN;tr|F5H4V9|F5H4V9_HUMAN;tr|F5GWT2|F5GWT2_HUMAN;tr|J3QK82|J3QK82_HUMAN;tr|A0A087WYJ3|A0A087WYJ3_HUMAN","sp|Q16342|PDCD2_HUMAN;tr|F5H4V9|F5H4V9_HUMAN",2661,"Q16342","PDCD2_HUMAN","Programmed cell death protein 2",null,"PDCD2"]
["21.7542","19.2929","21.0107","20.8526","19.8233","21.3162",{"$nulls":9},3,3,3,"21.8","21.8","21.8","24.992",0,"39.025",229590000,24,"0.00845589",1,"0.0219059","0.025713","sp|Q9H7E9|CH033_HUMAN","sp|Q9H7E9|CH033_HUMAN",4506,"Q9H7E9","CH033_HUMAN","UPF0488 protein C8orf33",null,"C8orf33"]
["20.4469","19.4762","20.056","20.559","19.5878","19.771",{"$nulls":3},"cellular response to lipopolysaccharide;inflammatory response;macroautophagy;negative regulation of protein K63-linked ubiquitination;phospholipid metabolic process;positive regulation of dendrite extension;positive regulation of neuron migration;positive regulation of phospholipase A2 activity;positive regulation of synaptic vesicle recycling;prostaglandin metabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;signal transduction;ubiquitin recycling;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway","phospholipase A2 activator activity;ubiquitin binding","cell junction;cytoplasm;extracellular exosome;nucleus;synapse","Protein processing in endoplasmic reticulum",null,null,13,13,13,"24.3","24.3","24.3","87.156",0,"134.79",449240000,49,"0.0165445",1,"0.020455","0.049864","sp|Q9Y263|PLAP_HUMAN;tr|E5RIM3|E5RIM3_HUMAN;tr|H0YBW4|H0YBW4_HUMAN;tr|H0YC16|H0YC16_HUMAN;tr|H0YAU9|H0YAU9_HUMAN","sp|Q9Y263|PLAP_HUMAN;tr|E5RIM3|E5RIM3_HUMAN;tr|H0YBW4|H0YBW4_HUMAN",5204,"Q9Y263","PLAP_HUMAN","Phospholipase A-2-activating protein","LA2P;LAP","PLAA"]
["23.8985","23.3017","24.4203","24.5184","23.0158","24.0269",{"$nulls":3},"cellular response to testosterone stimulus;establishment of endothelial barrier;establishment of epithelial cell apical/basal polarity;gland morphogenesis;immunological synapse formation;interleukin-12-mediated signaling pathway;leukocyte cell-cell adhesion;leukocyte migration;membrane to membrane docking;movement of cell or subcellular component;positive regulation of cellular protein catabolic process;positive regulation of early endosome to late endosome transport;positive regulation of gene expression;positive regulation of podosome assembly;positive regulation of protein localization to early endosome;regulation of cell shape;regulation of cell size;regulation of lymphocyte migration;regulation of organelle assembly;T cell aggregation;T cell migration;T cell proliferation","actin binding;cell adhesion molecule binding;double-stranded RNA binding;enzyme binding;protein kinase binding;receptor binding;structural constituent of cytoskeleton","apical part of cell;apical plasma membrane;basolateral plasma membrane;blood microparticle;cell periphery;cell surface;cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular space;filopodium;focal adhesion;invadopodium;microvillus;microvillus membrane;myelin sheath;nucleus;perinuclear region of cytoplasm;plasma membrane;pseudopodium;uropod;vesicle","Leukocyte transendothelial migration;Measles;Proteoglycans in cancer;Regulation of actin cytoskeleton;Tight junction",null,null,36,26,25,62,48,"45.6","67.819",0,"323.31",5908600000,186,"0.0119368",1,"0.0198072","0.036158","sp|P26038|MOES_HUMAN;tr|V9GZ54|V9GZ54_HUMAN","sp|P26038|MOES_HUMAN",1300,"P26038","MOES_HUMAN","Moesin {ECO:0000303|PubMed:1924289}",null,"MSN"]
["24.5822","22.4084","23.2883","24.529","22.3027","23.3878",{"$nulls":3},"tumor necrosis factor-mediated signaling pathway","peroxidase activity;protein-disulfide reductase activity","cytosol;extracellular exosome",{"$nulls":3},5,5,5,"53.7","53.7","53.7","13.941",0,"42.452",961950000,49,"0.00719654",1,"0.019743","0.0219143","sp|Q9BRA2|TXD17_HUMAN;tr|I3L0K2|I3L0K2_HUMAN;tr|I3L3M7|I3L3M7_HUMAN;tr|I3L2R6|I3L2R6_HUMAN","sp|Q9BRA2|TXD17_HUMAN;tr|I3L0K2|I3L0K2_HUMAN;tr|I3L3M7|I3L3M7_HUMAN;tr|I3L2R6|I3L2R6_HUMAN",4157,"Q9BRA2","TXD17_HUMAN","Thioredoxin domain-containing protein 17",null,"TXNDC17"]
["20.0511","18.6996","21.0318","20.1482","18.7017","20.8762",{"$nulls":3},"RNA processing","ATP binding;RNA binding;RNA-3'-phosphate cyclase activity","nucleoplasm;nucleus",{"$nulls":3},5,5,5,"19.7","19.7","19.7","39.336",0,"11.627",214060000,18,"0.00663866",1,"0.0188179","0.0202282","sp|O00442|RTCA_HUMAN;tr|A6NIC1|A6NIC1_HUMAN","sp|O00442|RTCA_HUMAN",238,"O00442","RTCA_HUMAN","RNA 3'-terminal phosphate cyclase","NA cyclase;NA-3'-phosphate cyclase","RTCA"]
["22.4003","21.5562","22.3128","22.3244","21.9122","21.9785",{"$nulls":3},"cellular response to lithium ion;DNA ligation involved in DNA repair;DNA recombination;double-strand break repair;double-strand break repair via nonhomologous end joining;establishment of integrated proviral latency;positive regulation of ligase activity;response to X-ray","identical protein binding;protein C-terminus binding","cytosol;DNA ligase IV complex;DNA-dependent protein kinase-DNA ligase 4 complex;nonhomologous end joining complex;nucleoplasm;nucleus","Non-homologous end-joining",null,null,14,14,14,"45.2","45.2","45.2","38.286",0,"62.466",746980000,51,"0.0202583",1,"0.018055","0.0608138","sp|Q13426|XRCC4_HUMAN","sp|Q13426|XRCC4_HUMAN",2352,"Q13426","XRCC4_HUMAN","DNA repair protein XRCC4",null,"XRCC4"]
["26.7561","22.8463","25.3908","26.8653","23.0114","25.0729",{"$nulls":3},"translational elongation","translation elongation factor activity","cytoplasm;cytosol;eukaryotic translation elongation factor 1 complex",{"$nulls":3},14,11,11,"76.4","71.1","71.1","24.763",0,"323.31",5607800000,142,"0.00297039",1,"0.0145194","0.00908848","sp|P24534|EF1B_HUMAN;tr|C9JZW3|C9JZW3_HUMAN;tr|F2Z2G2|F2Z2G2_HUMAN;tr|F8WF65|F8WF65_HUMAN","sp|P24534|EF1B_HUMAN",1279,"P24534","EF1B_HUMAN","Elongation factor 1-beta","F-1-beta","EEF1B2"]
[1,"14.2622","17.0563",1,"14.0417","17.2369",{"$nulls":3},"cell migration;cytoskeleton organization","actin binding","cytoskeleton;cytosol;membrane",{"$nulls":3},3,3,3,"6.9","6.9","6.9","38.858","0.0011898","3.4485",26924000,3,"0.000618964",1,"0.0133184","0.00189894","sp|Q9H939|PPIP2_HUMAN","sp|Q9H939|PPIP2_HUMAN",4531,"Q9H939","PPIP2_HUMAN","Proline-serine-threonine phosphatase-interacting protein 2","EST phosphatase-interacting protein 2","PSTPIP2"]
["20.0784","18.861","20.3305","20.6057","18.5166","20.1176",{"$nulls":3},"cell cycle arrest;G1/S transition of mitotic cell cycle;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;post-translational protein modification;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;viral process","protein complex binding;ubiquitin protein ligase binding","Cul2-RING ubiquitin ligase complex;cytosol;nucleolus;nucleoplasm;VCB complex","HIF-1 signaling pathway;Pathways in cancer;Renal cell carcinoma;Ubiquitin mediated proteolysis",null,null,15,15,15,"23.9","23.9","23.9","86.982",0,"52.164",448630000,44,"0.00421842",1,"0.0100161","0.0128888","sp|Q13617|CUL2_HUMAN;tr|A0A0A0MTN0|A0A0A0MTN0_HUMAN;tr|Q5T2B5|Q5T2B5_HUMAN;tr|Q5T2B7|Q5T2B7_HUMAN","sp|Q13617|CUL2_HUMAN;tr|A0A0A0MTN0|A0A0A0MTN0_HUMAN;tr|Q5T2B5|Q5T2B5_HUMAN",2393,"Q13617","CUL2_HUMAN","Cullin-2","UL-2","CUL2"]
["24.4544","22.6783","23.8784","24.2296","22.9407","23.812",{"$nulls":4},"GTP binding",{"$nulls":4},18,18,10,"55.3","55.3","36.5","49.005",0,"253.79",3280100000,131,"0.00487968",1,"0.0096302","0.014898","tr|D6RGI3|D6RGI3_HUMAN;sp|Q9NVA2|SEP11_HUMAN;tr|D6RER5|D6RER5_HUMAN;tr|D6RDU5|D6RDU5_HUMAN;tr|H0Y961|H0Y961_HUMAN;tr|D6RDP1|D6RDP1_HUMAN;tr|D6R9Y6|D6R9Y6_HUMAN;tr|H0Y9G8|H0Y9G8_HUMAN","tr|D6RGI3|D6RGI3_HUMAN;sp|Q9NVA2|SEP11_HUMAN;tr|D6RER5|D6RER5_HUMAN;tr|D6RDU5|D6RDU5_HUMAN",4754,"D6RGI3","D6RGI3_HUMAN"]
["20.649","19.1681","19.4219","20.4106","18.6849","20.1165",{"$nulls":3},"cell proliferation;cellular response to rapamycin;mRNA stabilization;negative regulation of translation;positive regulation of macroautophagy;positive regulation of viral genome replication;response to amino acid starvation;TOR signaling;TORC1 signaling;translational initiation","cadherin binding;eukaryotic initiation factor 4E binding;mRNA 3'-UTR binding;mRNA 5'-UTR binding;RNA binding;RNA cap binding;translation activator activity;translation initiation factor binding","cytoplasm;cytoplasmic stress granule;membrane",{"$nulls":3},22,22,22,"34.2","34.2","34.2","123.51",0,"107.28",603690000,52,"0.00419824",1,"0.00900841","0.0128274","sp|Q6PKG0|LARP1_HUMAN;tr|A0A0B4J210|A0A0B4J210_HUMAN;tr|E5RH50|E5RH50_HUMAN;tr|H0YC33|H0YC33_HUMAN;tr|H0YBW1|H0YBW1_HUMAN;tr|H0YC73|H0YC73_HUMAN;tr|H0YAN4|H0YAN4_HUMAN;tr|H0YBR8|H0YBR8_HUMAN;tr|H0YAX9|H0YAX9_HUMAN;tr|E5RHK4|E5RHK4_HUMAN;tr|H0YBM7|H0YBM7_HUMAN;sp|Q659C4|LAR1B_HUMAN","sp|Q6PKG0|LARP1_HUMAN;tr|A0A0B4J210|A0A0B4J210_HUMAN;tr|E5RH50|E5RH50_HUMAN",3041,"Q6PKG0","LARP1_HUMAN","La-related protein 1",null,"LARP1"]
["23.0985","22.1917","22.9444","23.2918","22.0754","22.8413",{"$nulls":3},"carnitine biosynthetic process;cellular aldehyde metabolic process;hormone metabolic process;neurotransmitter biosynthetic process;oxidation-reduction process","1-pyrroline dehydrogenase activity;3-chloroallyl aldehyde dehydrogenase activity;4-trimethylammoniobutyraldehyde dehydrogenase activity;aldehyde dehydrogenase (NAD) activity;aminobutyraldehyde dehydrogenase activity","cytoplasm;cytosol;extracellular exosome","Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Fatty acid degradation;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Lysine degradation;Metabolic pathways;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,19,19,19,"41.7","41.7","41.7","53.801",0,"141.35",1818100000,95,"0.00633106",1,"0.00872739","0.0192976","sp|P49189|AL9A1_HUMAN","sp|P49189|AL9A1_HUMAN",1645,"P49189","AL9A1_HUMAN","4-trimethylaminobutyraldehyde dehydrogenase","MABADH","ALDH9A1"]
["20.9123","21.2938","21.2481","21.0767","20.8737","21.4806",{"$nulls":3},"positive regulation of collagen fibril organization","procollagen galactosyltransferase activity","endoplasmic reticulum lumen;membrane","Lysine degradation;Other types of O-glycan biosynthesis",null,null,18,18,18,"28.8","28.8","28.8","71.635",0,"101.22",833720000,62,"0.0118271",1,"0.00770887","0.0358301","sp|Q8NBJ5|GT251_HUMAN;tr|M0QYH0|M0QYH0_HUMAN;tr|M0QX72|M0QX72_HUMAN","sp|Q8NBJ5|GT251_HUMAN",3454,"Q8NBJ5","GT251_HUMAN","Procollagen galactosyltransferase 1",null,"COLGALT1"]
["21.5396","20.8022","21.3947","21.5678","20.954","21.192",{"$nulls":3},"cellular response to stimulus;myelination;negative regulation of translational initiation in response to stress;oligodendrocyte development;ovarian follicle development;regulation of molecular function;regulation of translation;response to glucose;response to heat;response to peptide hormone;translational initiation","translation initiation factor activity;translation initiation factor binding","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex","Herpes simplex virus 1 infection;RNA transport",null,null,20,20,2,"49.5","49.5","6.3","57.557",0,"156.87",3728300000,200,"0.00864094",1,"0.00755882","0.0262703","sp|Q9UI10|EI2BD_HUMAN;tr|E7ERK9|E7ERK9_HUMAN;tr|A0A087WW69|A0A087WW69_HUMAN;tr|F8W8L6|F8W8L6_HUMAN;tr|H7C2L8|H7C2L8_HUMAN;tr|F8WEV6|F8WEV6_HUMAN","sp|Q9UI10|EI2BD_HUMAN;tr|E7ERK9|E7ERK9_HUMAN;tr|A0A087WW69|A0A087WW69_HUMAN",5040,"Q9UI10","EI2BD_HUMAN","Translation initiation factor eIF-2B subunit delta",null,"EIF2B4"]
["22.2387","20.1351","21.1467","21.9037","20.0509","21.5501",{"$nulls":3},"proteolysis","serine-type endopeptidase activity;serine-type exopeptidase activity;serine-type peptidase activity","cytoplasm;cytosol;membrane;nucleus","Renin-angiotensin system",null,null,23,23,23,"46.2","46.2","46.2","80.699",0,"213.86",1262500000,115,"0.00206564",1,"0.0052611","0.00632674","sp|P48147|PPCE_HUMAN","sp|P48147|PPCE_HUMAN",1621,"P48147","PPCE_HUMAN","Prolyl endopeptidase","E","PREP"]
["28.8429","27.8676","28.4939","28.9375","27.7302","28.5231",{"$nulls":3},"carbohydrate metabolic process;lactate metabolic process;NAD metabolic process;pyruvate metabolic process","identical protein binding;kinase binding;L-lactate dehydrogenase activity;NAD binding","cytoplasm;cytosol;extracellular exosome;membrane;membrane raft;mitochondrion;myelin sheath","Central carbon metabolism in cancer;Cysteine and methionine metabolism;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism",null,null,18,17,17,"59.3","55.7","55.7","36.638",0,"323.31",61996000000,523,"0.00324721",1,"0.00451724","0.00993233","sp|P07195|LDHB_HUMAN;tr|A8MW50|A8MW50_HUMAN;tr|C9J7H8|C9J7H8_HUMAN;tr|F5H793|F5H793_HUMAN","sp|P07195|LDHB_HUMAN;tr|A8MW50|A8MW50_HUMAN",928,"P07195","LDHB_HUMAN","L-lactate dehydrogenase B chain","DH-B","LDHB"]
["26.1712","24.5165","25.3559","26.0024","24.5857","25.4445",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;toxin transport","ATP binding;identical protein binding;protein binding involved in protein folding;unfolded protein binding","cell body;chaperonin-containing T-complex;cytoplasm;cytosol;extracellular exosome;microtubule;mitochondrion;zona pellucida receptor complex",{"$nulls":3},33,33,33,"72.4","72.4","72.4","59.366",0,"323.31",14467000000,444,"0.00187619",1,"0.00362587","0.00574773","sp|Q99832|TCPH_HUMAN;tr|F8WAM2|F8WAM2_HUMAN;tr|F8WBP8|F8WBP8_HUMAN;tr|A0A0D9SG95|A0A0D9SG95_HUMAN","sp|Q99832|TCPH_HUMAN",4114,"Q99832","TCPH_HUMAN","T-complex protein 1 subunit eta","CP-1-eta","CCT7"]
["24.3381","22.785","23.9961","24.4318","22.6465","24.0327",{"$nulls":3},"actomyosin contractile ring assembly;apoptotic process;bicellular tight junction assembly;cell separation after cytokinesis;maintenance of epithelial cell apical/basal polarity;mitotic cytokinesis;multivesicular body assembly;positive regulation of exosomal secretion;positive regulation of extracellular exosome assembly;protein homooligomerization;protein transport;regulation of centrosome duplication;regulation of extracellular exosome assembly;regulation of membrane permeability;ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;viral budding;viral budding via host ESCRT complex;viral life cycle","calcium-dependent protein binding;protein homodimerization activity;proteinase activated receptor binding","actomyosin;bicellular tight junction;cytosol;endoplasmic reticulum exit site;extracellular exosome;extracellular vesicle;Flemming body;focal adhesion;immunological synapse;melanosome;membrane;microtubule organizing center;myelin sheath","Endocytosis",null,null,46,46,46,"61.3","61.3","61.3","96.022",0,"323.31",6966500000,327,"0.00125084",1,"0.00275103","0.0038347","sp|Q8WUM4|PDC6I_HUMAN;tr|C9IZF9|C9IZF9_HUMAN;tr|F8WEQ7|F8WEQ7_HUMAN;tr|F8WBR8|F8WBR8_HUMAN;tr|F8WDK9|F8WDK9_HUMAN","sp|Q8WUM4|PDC6I_HUMAN",3605,"Q8WUM4","PDC6I_HUMAN","Programmed cell death 6-interacting protein","DCD6-interacting protein","PDCD6IP"]
["22.0613","20.1134","21.9521","22.1191","20.2964","21.7048",{"$nulls":3},"steroid biosynthetic process","fatty-acyl-CoA binding;protein kinase A regulatory subunit binding","Golgi apparatus;Golgi membrane;membrane;mitochondrion",{"$nulls":3},11,11,11,"29.7","29.7","29.7","60.593",0,"110.71",655780000,62,"0.000840939",1,"0.00216357","0.00257928","sp|Q9H3P7|GCP60_HUMAN","sp|Q9H3P7|GCP60_HUMAN",4449,"Q9H3P7","GCP60_HUMAN","Golgi resident protein GCP60",null,"ACBD3"]
["22.1356","21.5251","21.9623","22.4468","21.2449","21.9249",{"$nulls":3},"DNA replication;tRNA metabolic process","aminoacyl-tRNA editing activity;DNA binding;D-tyrosyl-tRNA(Tyr) deacylase activity;metal ion binding;tRNA binding","cytoplasm;cytosol;nucleolus",{"$nulls":3},3,3,3,"18.2","18.2","18.2","23.423",0,"25.248",320520000,25,"0.00176522",1,"0.00212288","0.00540847","sp|Q8TEA8|DTD1_HUMAN;tr|A0A087WZV9|A0A087WZV9_HUMAN","sp|Q8TEA8|DTD1_HUMAN",3573,"Q8TEA8","DTD1_HUMAN","D-aminoacyl-tRNA deacylase 1 {ECO:0000250|UniProtKB:Q8IIS0}","TD","DTD1"]
["17.3568","17.7819","17.1532","17.6308","17.3702","17.2874",{"$nulls":4},"chromatin binding;DNA binding transcription factor activity;sequence-specific DNA binding;zinc ion binding","intracellular membrane-bounded organelle;nucleus",{"$nulls":3},14,8,8,"33.9","21.6","21.6","58.726",0,"16.975",229200000,20,"0.00178622",1,"0.00116094","0.00547266","tr|E7EQY4|E7EQY4_HUMAN;tr|E7EV10|E7EV10_HUMAN;sp|Q9BTC8|MTA3_HUMAN;tr|E9PCS8|E9PCS8_HUMAN;tr|D6W5A2|D6W5A2_HUMAN;tr|E9PF88|E9PF88_HUMAN","tr|E7EQY4|E7EQY4_HUMAN;tr|E7EV10|E7EV10_HUMAN;sp|Q9BTC8|MTA3_HUMAN;tr|E9PCS8|E9PCS8_HUMAN;tr|D6W5A2|D6W5A2_HUMAN",4203,"E7EQY4","E7EQY4_HUMAN",null,null,"MTA3"]
["22.0833","20.0487","21.0044","21.7893","20.3904","20.9577",{"$nulls":3},"phosphatidylethanolamine biosynthetic process;phospholipid biosynthetic process","ethanolamine-phosphate cytidylyltransferase activity","endoplasmic reticulum membrane","Glycerophospholipid metabolism;Metabolic pathways;Phosphonate and phosphinate metabolism",null,null,12,12,12,"39.8","39.8","39.8","43.835",0,"74.726",590640000,49,"0.000144091",1,"-0.000315984","-0.000442301","sp|Q99447|PCY2_HUMAN;tr|I3L1R7|I3L1R7_HUMAN;tr|I3L1L9|I3L1L9_HUMAN;tr|I3L3V9|I3L3V9_HUMAN;tr|I3L2Q1|I3L2Q1_HUMAN;tr|I3L1C4|I3L1C4_HUMAN;tr|I3L1F9|I3L1F9_HUMAN","sp|Q99447|PCY2_HUMAN;tr|I3L1R7|I3L1R7_HUMAN;tr|I3L1L9|I3L1L9_HUMAN;tr|I3L3V9|I3L3V9_HUMAN;tr|I3L2Q1|I3L2Q1_HUMAN",4062,"Q99447","PCY2_HUMAN","Ethanolamine-phosphate cytidylyltransferase",null,"PCYT2"]
["25.0491","23.9581","24.4906","25.1117","23.6711","24.7171",{"$nulls":3},"cell redox homeostasis;cellular response to oxidative stress","disulfide oxidoreductase activity;oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;protein disulfide oxidoreductase activity;protein-disulfide reductase activity;thioredoxin-disulfide reductase activity","cytoplasm;cytosol;extracellular exosome;nucleus;proteasome complex",{"$nulls":3},19,19,19,"66.1","66.1","66.1","32.251",0,"309.28",3273600000,156,"0.000417604",1,"-0.000682831","-0.00128148","sp|O43396|TXNL1_HUMAN;tr|K7ER96|K7ER96_HUMAN;tr|K7EML9|K7EML9_HUMAN;tr|K7EME7|K7EME7_HUMAN;tr|K7EPB7|K7EPB7_HUMAN;tr|K7EKG2|K7EKG2_HUMAN","sp|O43396|TXNL1_HUMAN;tr|K7ER96|K7ER96_HUMAN",415,"O43396","TXNL1_HUMAN","Thioredoxin-like protein 1",null,"TXNL1"]
["17.7866","16.289","16.4957","18.3215","16.1129","16.1414",{"$nulls":3},"autophagy;endocytic recycling;Golgi organization;Golgi vesicle transport;lipid transport;lysosomal transport;protein transport;retrograde transport, endosome to Golgi",null,"cytosol;EARP complex;GARP complex;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;membrane;nucleolus;recycling endosome;trans-Golgi network membrane",{"$nulls":3},4,4,4,"9.5","9.5","9.5","86.041",0,"12.683",51037000,8,"0.000565105",1,"-0.00150617","-0.00173381","sp|Q9UID3|VPS51_HUMAN;tr|E9PRV0|E9PRV0_HUMAN;tr|E9PKX7|E9PKX7_HUMAN;tr|E9PKE5|E9PKE5_HUMAN;tr|E9PMB6|E9PMB6_HUMAN;tr|E9PQD5|E9PQD5_HUMAN;tr|E9PJ36|E9PJ36_HUMAN","sp|Q9UID3|VPS51_HUMAN;tr|E9PRV0|E9PRV0_HUMAN;tr|E9PKX7|E9PKX7_HUMAN",5049,"Q9UID3","VPS51_HUMAN","Vacuolar protein sorting-associated protein 51 homolog",null,"VPS51"]
["26.044","24.2133","24.7193","25.4446","24.6345","24.9031",{"$nulls":3},"interleukin-12-mediated signaling pathway;L-methionine salvage from methylthioadenosine;nucleobase-containing compound metabolic process;purine ribonucleoside salvage","phosphorylase activity;S-methyl-5-thioadenosine phosphorylase activity","cytosol;extracellular exosome;nucleus","Cysteine and methionine metabolism;Metabolic pathways",null,null,20,20,20,"76.3","76.3","76.3","31.236",0,"323.31",6522800000,140,"0.00100403",1,"-0.0018336","-0.00307893","sp|Q13126|MTAP_HUMAN;tr|B4DUC8|B4DUC8_HUMAN;tr|J3QSB7|J3QSB7_HUMAN;tr|F2Z2F3|F2Z2F3_HUMAN;tr|F8WES2|F8WES2_HUMAN;tr|J3KRN1|J3KRN1_HUMAN","sp|Q13126|MTAP_HUMAN;tr|B4DUC8|B4DUC8_HUMAN;tr|J3QSB7|J3QSB7_HUMAN",2309,"Q13126","MTAP_HUMAN","S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}",null,"MTAP"]
["21.6476","17.5104","20.7713","21.4348","17.2001","21.3044",{"$nulls":3},"cell differentiation;DNA replication initiation;DNA unwinding involved in DNA replication;negative regulation of transcription, DNA-templated;nervous system development;positive regulation of cell proliferation;transcription, DNA-templated","double-stranded telomeric DNA binding;purine-rich negative regulatory element binding;RNA binding;single-stranded DNA binding;SMAD binding;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;transcription factor binding;translation repressor activity, nucleic acid binding","cytoplasm;dendrite;DNA replication factor A complex;neuronal cell body;nuclear chromosome, telomeric region;nucleus",{"$nulls":3},4,4,4,18,18,18,"34.91",0,"29.222",117830000,16,"0.000572021",1,"-0.00329145","-0.00175502","sp|Q00577|PURA_HUMAN","sp|Q00577|PURA_HUMAN",2119,"Q00577","PURA_HUMAN","Transcriptional activator protein Pur-alpha",null,"PURA"]
["18.301","16.6457","18.5474","17.4903","17.7237","18.2924",{"$nulls":9},4,4,4,"6.1","6.1","6.1","86.557",0,"11.474",100420000,11,"0.00208987",1,"-0.00411479","-0.00640077","sp|Q5W0V3|F16B1_HUMAN;tr|Q5W0V4|Q5W0V4_HUMAN","sp|Q5W0V3|F16B1_HUMAN",2913,"Q5W0V3","F16B1_HUMAN","Protein FAM160B1",null,"FAM160B1"]
["24.7317","23.2598","24.0039","24.7849","23.2536","23.9697",{"$nulls":3},"ATP metabolic process;platelet degranulation","ATP binding;ATPase activity;cadherin binding;GTP binding;metal ion binding","centrosome;cytoplasm;cytosol;extracellular exosome;extracellular region;membrane;nucleolus;platelet alpha granule lumen",{"$nulls":3},23,23,23,"66.4","66.4","66.4","44.743",0,"323.31",4738300000,152,"0.00224627",1,"-0.00421906","-0.00687858","sp|Q9NTK5|OLA1_HUMAN;tr|J3KQ32|J3KQ32_HUMAN;tr|C9JTK6|C9JTK6_HUMAN;tr|C9JCJ9|C9JCJ9_HUMAN","sp|Q9NTK5|OLA1_HUMAN;tr|J3KQ32|J3KQ32_HUMAN",4722,"Q9NTK5","OLA1_HUMAN","Obg-like ATPase 1 {ECO:0000255|HAMAP-Rule:MF_03167}",null,"OLA1"]
["19.5028","17.9196","18.2841","19.4118","17.7459","18.5642",{"$nulls":4},"GTP binding","septin complex",{"$nulls":3},11,4,4,"32.3","18.1","18.1","49.303",0,"39.495",120960000,22,"0.00246133",1,"-0.00511297","-0.00753527","tr|B1AMS2|B1AMS2_HUMAN;sp|Q14141|SEPT6_HUMAN","tr|B1AMS2|B1AMS2_HUMAN;sp|Q14141|SEPT6_HUMAN",2438,"B1AMS2","B1AMS2_HUMAN"]
["21.3036","17.6075","20.5844","21.5094","17.4688","20.5432",{"$nulls":5},"cytosol;nucleoplasm",{"$nulls":3},4,4,4,"27.5","27.5","27.5","21.537",0,"16.488",160490000,19,"0.0016951",1,"-0.0086352","-0.00519402","tr|Q5TD07|Q5TD07_HUMAN;sp|P16083|NQO2_HUMAN;tr|Q5TD05|Q5TD05_HUMAN","tr|Q5TD07|Q5TD07_HUMAN;sp|P16083|NQO2_HUMAN;tr|Q5TD05|Q5TD05_HUMAN",1129,"Q5TD07","Q5TD07_HUMAN",null,null,"NQO2"]
["23.1346","21.5194","22.5586","23.0109","21.4499","22.7812",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},51,51,51,"49.2","49.2","49.2","141.44",0,"323.31",4538400000,249,"0.00471782",1,"-0.00977262","-0.0144065","tr|A0A024R4E5|A0A024R4E5_HUMAN;sp|Q00341|VIGLN_HUMAN;tr|H0Y394|H0Y394_HUMAN;tr|H7C0A4|H7C0A4_HUMAN;tr|C9J5E5|C9J5E5_HUMAN;tr|C9JIZ1|C9JIZ1_HUMAN;tr|C9JZI8|C9JZI8_HUMAN;tr|C9JHZ8|C9JHZ8_HUMAN;tr|C9JES8|C9JES8_HUMAN;tr|C9JHS7|C9JHS7_HUMAN;tr|H7BZC3|H7BZC3_HUMAN;tr|H7C2D1|H7C2D1_HUMAN;tr|C9JT62|C9JT62_HUMAN;tr|C9JK79|C9JK79_HUMAN;tr|C9JBS3|C9JBS3_HUMAN;tr|C9JEJ8|C9JEJ8_HUMAN;tr|C9JHN6|C9JHN6_HUMAN;tr|C9JMQ6|C9JMQ6_HUMAN;tr|C9JQ82|C9JQ82_HUMAN;tr|C9JHS9|C9JHS9_HUMAN;tr|C9J739|C9J739_HUMAN;tr|H7C3D0|H7C3D0_HUMAN","tr|A0A024R4E5|A0A024R4E5_HUMAN;sp|Q00341|VIGLN_HUMAN;tr|H0Y394|H0Y394_HUMAN",5429,"A0A024R4E5","A0A024R4E5_HUMAN"]
["17.9413","16.1999","17.3246","18.2207","15.8268","17.4491",{"$nulls":3},"inositol metabolic process;inositol phosphate biosynthetic process;inositol phosphate metabolic process","ATP binding;diphosphoinositol-pentakisphosphate kinase activity;inositol heptakisphosphate kinase activity;inositol hexakisphosphate 1-kinase activity;inositol hexakisphosphate 3-kinase activity;inositol hexakisphosphate 5-kinase activity;inositol hexakisphosphate kinase activity;inositol-1,3,4,5,6-pentakisphosphate kinase activity","cytosol","Phosphatidylinositol signaling system",null,null,10,10,6,"11.8","11.8","7.6","140.41",0,"29.058",196050000,27,"0.00385198",1,"-0.0102479","-0.0117741","sp|O43314|VIP2_HUMAN;tr|A0A087WZV0|A0A087WZV0_HUMAN;tr|A0A087WWN8|A0A087WWN8_HUMAN;tr|D6RBU4|D6RBU4_HUMAN;tr|F8W9A8|F8W9A8_HUMAN;tr|B7WPL9|B7WPL9_HUMAN;sp|Q6PFW1|VIP1_HUMAN;tr|D6RFG4|D6RFG4_HUMAN;tr|H0Y9M0|H0Y9M0_HUMAN","sp|O43314|VIP2_HUMAN;tr|A0A087WZV0|A0A087WZV0_HUMAN",407,"O43314","VIP2_HUMAN","Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2",null,"PPIP5K2"]
["21.6671","20.6823","21.6947","22.3088","20.0418","21.7298",{"$nulls":3},"protein destabilization;regulation of protein complex assembly;regulation of signal transduction",null,"endoplasmic reticulum membrane;integral component of membrane;membrane",{"$nulls":3},18,18,18,"36.1","36.1","36.1","62.974",0,"90.212",861250000,87,"0.00523508",1,"-0.012097","-0.0159767","sp|Q969V3|NCLN_HUMAN;tr|K7EMW4|K7EMW4_HUMAN;tr|K7ELZ9|K7ELZ9_HUMAN;tr|A0A0C4DGP7|A0A0C4DGP7_HUMAN;tr|K7ENM2|K7ENM2_HUMAN;tr|K7EQ66|K7EQ66_HUMAN;tr|K7EN96|K7EN96_HUMAN","sp|Q969V3|NCLN_HUMAN;tr|K7EMW4|K7EMW4_HUMAN;tr|K7ELZ9|K7ELZ9_HUMAN;tr|A0A0C4DGP7|A0A0C4DGP7_HUMAN",3771,"Q969V3","NCLN_HUMAN","Nicalin",null,"NCLN"]
["21.0352","20.0401","20.5789","21.0748","20.0787","20.5402",{"$nulls":9},41,41,41,"21.2","21.2","21.2","308.77",0,"190.44",1537200000,136,"0.01068",1,"-0.0131804","-0.032396","tr|E7EPN9|E7EPN9_HUMAN;sp|Q9Y520|PRC2C_HUMAN;tr|H7C5N8|H7C5N8_HUMAN;tr|A0A0A0MS30|A0A0A0MS30_HUMAN","tr|E7EPN9|E7EPN9_HUMAN;sp|Q9Y520|PRC2C_HUMAN",5341,"E7EPN9","E7EPN9_HUMAN",null,null,"PRRC2C"]
["19.6931","16.9251","19.3685","19.636","16.6014","19.7909",{"$nulls":3},"cell cycle;chaperone mediated protein folding requiring cofactor;clathrin coat disassembly;clathrin-coated pit assembly;clathrin-dependent endocytosis;endoplasmic reticulum organization;establishment of protein localization to Golgi;Golgi organization;Golgi to lysosome transport;membrane organization;negative regulation of neuron projection development;protein localization to plasma membrane;receptor-mediated endocytosis;synaptic vesicle uncoating","ATP binding;chaperone binding;cyclin binding;protein serine/threonine kinase activity","cytosol;focal adhesion;Golgi apparatus;intracellular membrane-bounded organelle;membrane;perinuclear region of cytoplasm;synapse;vesicle",{"$nulls":3},12,12,12,"12.8","12.8","12.8","143.19",0,"192.49",324640000,44,"0.00333882",1,"-0.0138563","-0.0102115","sp|O14976|GAK_HUMAN;tr|A0A087X1U9|A0A087X1U9_HUMAN;tr|H0Y8H5|H0Y8H5_HUMAN;tr|D6RAW3|D6RAW3_HUMAN;tr|D6RF16|D6RF16_HUMAN;tr|D6RAQ7|D6RAQ7_HUMAN;tr|D6RE78|D6RE78_HUMAN","sp|O14976|GAK_HUMAN",319,"O14976","GAK_HUMAN","Cyclin-G-associated kinase",null,"GAK"]
["17.4154","17.1468","19.2547","17.916","16.7559","19.187",{"$nulls":3},"positive regulation of exocytosis;protein transport;vesicle-mediated transport","GTP binding;GTPase activity","endoplasmic reticulum membrane;extracellular exosome;Golgi membrane;plasma membrane;presynapse",{"$nulls":3},8,2,2,"45.8","14.8","14.8","24.214",0,"6.1096",43711000,10,"0.00475001",1,"-0.0139999","-0.0145042","sp|Q8WUD1|RAB2B_HUMAN;tr|Q5HYI5|Q5HYI5_HUMAN;tr|E9PE37|E9PE37_HUMAN;tr|H0YD31|H0YD31_HUMAN;tr|Q6PIK3|Q6PIK3_HUMAN","sp|Q8WUD1|RAB2B_HUMAN;tr|Q5HYI5|Q5HYI5_HUMAN",3598,"Q8WUD1","RAB2B_HUMAN","Ras-related protein Rab-2B",null,"RAB2B"]
["17.2113",1,"16.8218","17.2873",1,"16.7899",{"$nulls":3},"autophagy;cilium assembly;clathrin-dependent endocytosis;membrane invagination;membrane organization;plasma membrane tubulation;positive regulation of filopodium assembly;vesicle budding from membrane;vesicle organization;vesicle transport along actin filament","cadherin binding;GTPase binding;lipid binding","cell cortex;cytoplasm;cytoplasmic vesicle;cytoskeleton;cytosol;extracellular exosome;plasma membrane",{"$nulls":3},5,5,5,"10.9","10.9","10.9","70.065",0,"18.866",28204000,7,"0.000633534",1,"-0.0146891","-0.0019436","sp|Q5T0N5|FBP1L_HUMAN;tr|S4R347|S4R347_HUMAN;tr|A0A075B6Q2|A0A075B6Q2_HUMAN","sp|Q5T0N5|FBP1L_HUMAN;tr|S4R347|S4R347_HUMAN;tr|A0A075B6Q2|A0A075B6Q2_HUMAN",2858,"Q5T0N5","FBP1L_HUMAN","Formin-binding protein 1-like",null,"FNBP1L"]
[1,"17.8808","19.5712","20.2285","17.27",1,{"$nulls":4},"RNA binding",{"$nulls":4},9,1,1,"55.2","8.6","8.6","24.043","0.00041929","4.4379",35892000,3,"0.000600457",1,"-0.0155099","-0.0018422","tr|C9JSZ1|C9JSZ1_HUMAN","tr|C9JSZ1|C9JSZ1_HUMAN",5490,"C9JSZ1","C9JSZ1_HUMAN",null,null,"FUBP1"]
["23.8633","21.0397","20.9256","23.2905","19.1525","23.4336",{"$nulls":5},"endoplasmic reticulum tubular network;extracellular exosome;integral component of membrane",{"$nulls":3},3,3,3,"15.3","15.3","15.3","21.493",0,"20.779",337080000,7,"0.00308341",1,"-0.0160465","-0.00943307","sp|Q00765|REEP5_HUMAN;tr|B7Z332|B7Z332_HUMAN;tr|B7Z510|B7Z510_HUMAN;tr|H0Y8J8|H0Y8J8_HUMAN;tr|E2QRG8|E2QRG8_HUMAN","sp|Q00765|REEP5_HUMAN",2124,"Q00765","REEP5_HUMAN","Receptor expression-enhancing protein 5",null,"REEP5"]
["22.5703","21.2294","22.0843","23.0522","20.6939","22.1885",{"$nulls":3},"cellular response to growth factor stimulus;endocytic recycling;pinocytosis;positive regulation of peptidyl-tyrosine phosphorylation;protein homooligomerization;regulation of endocytosis","ATP binding;cadherin binding;calcium ion binding;GTP binding;nucleic acid binding","early endosome membrane;endoplasmic reticulum;extracellular exosome;membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;recycling endosome membrane","Endocytosis",null,null,25,24,20,"60.6","58.6","51.8","61.174",0,"207.96",1661000000,118,"0.00699197",1,"-0.0168788","-0.0212963","sp|Q9H223|EHD4_HUMAN;tr|A0A087WUA5|A0A087WUA5_HUMAN","sp|Q9H223|EHD4_HUMAN;tr|A0A087WUA5|A0A087WUA5_HUMAN",4421,"Q9H223","EHD4_HUMAN","EH domain-containing protein 4 {ECO:0000305}",null,"EHD4"]
["22.4249","21.2811","21.6005","22.7132","21.2412","21.4069",{"$nulls":4},"phosphoprotein phosphatase activity",{"$nulls":4},14,14,14,"38.8","38.8","38.8","55.096",0,"103.79",931200000,88,"0.0104271",1,"-0.0182527","-0.0316377","tr|H0YDU8|H0YDU8_HUMAN;sp|P53041|PPP5_HUMAN;tr|A8MU39|A8MU39_HUMAN","tr|H0YDU8|H0YDU8_HUMAN;sp|P53041|PPP5_HUMAN;tr|A8MU39|A8MU39_HUMAN",1791,"H0YDU8","H0YDU8_HUMAN","Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273}",null,"PPP5C"]
["20.9687","19.5517","20.5108","21.1272","19.4038","20.5595",{"$nulls":3},"transcription, DNA-templated","DNA binding;DNA-directed 5'-3' RNA polymerase activity;ribonucleoside binding","nucleoplasm",{"$nulls":3},31,31,31,"32.3","32.3","32.3","133.06",0,"154.79",1651700000,200,"0.00992698",1,"-0.0197951","-0.030137","tr|C9J2Y9|C9J2Y9_HUMAN;sp|P30876|RPB2_HUMAN;tr|C9J4M6|C9J4M6_HUMAN","tr|C9J2Y9|C9J2Y9_HUMAN;sp|P30876|RPB2_HUMAN;tr|C9J4M6|C9J4M6_HUMAN",1395,"C9J2Y9","C9J2Y9_HUMAN","DNA-directed RNA polymerase subunit beta {ECO:0000256|RuleBase:RU363031}",null,"POLR2B"]
[1,"16.1703","16.49",1,"15.5225","17.201",{"$nulls":3},"myelination;negative regulation of transcription, DNA-templated;positive regulation of transcription from RNA polymerase II promoter","DNA binding;sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;zinc ion binding","nucleus",{"$nulls":3},11,11,11,"40.8","40.8","40.8","42.155",0,"79.279",325440000,36,"0.000947798",1,"-0.0210762","-0.00290668","sp|P17028|ZNF24_HUMAN;tr|K7EPL1|K7EPL1_HUMAN;tr|K7EQP8|K7EQP8_HUMAN;tr|K7EPZ8|K7EPZ8_HUMAN","sp|P17028|ZNF24_HUMAN;tr|K7EPL1|K7EPL1_HUMAN",1144,"P17028","ZNF24_HUMAN","Zinc finger protein 24",null,"ZNF24"]
["18.3495","17.0374",1,"18.5725","16.8792",1,{"$nulls":4},"flavin adenine dinucleotide binding;tRNA dihydrouridine synthase activity",{"$nulls":4},3,3,3,"13.4","13.4","13.4","33.567",0,"6.6307",35695000,6,"0.000891224",1,"-0.0215969","-0.00273336","tr|H0YGW8|H0YGW8_HUMAN;sp|Q6P1R4|DUS1L_HUMAN;tr|J3QLE4|J3QLE4_HUMAN;tr|J3KT57|J3KT57_HUMAN;tr|F5H0Q0|F5H0Q0_HUMAN;tr|J3QKP9|J3QKP9_HUMAN;tr|J3QQZ0|J3QQZ0_HUMAN","tr|H0YGW8|H0YGW8_HUMAN;sp|Q6P1R4|DUS1L_HUMAN;tr|J3QLE4|J3QLE4_HUMAN",3004,"H0YGW8","H0YGW8_HUMAN",null,null,"DUS1L"]
["19.2846","17.841","18.3656","19.6879","17.6235","18.2504",{"$nulls":3},"activation of GTPase activity;cellular response to insulin stimulus;intracellular protein transport;membrane organization;negative regulation of vesicle fusion;regulation of vesicle fusion;vesicle-mediated transport","GTPase activator activity;Rab GTPase binding","cytoplasmic vesicle membrane;cytosol;endomembrane system;extracellular exosome;intracellular","Insulin resistance;Thyroid hormone signaling pathway",null,null,12,12,12,"14.1","14.1","14.1","146.56",0,"59.022",327270000,47,"0.0104584",1,"-0.0235621","-0.0317315","sp|O60343|TBCD4_HUMAN;tr|Q5JU47|Q5JU47_HUMAN","sp|O60343|TBCD4_HUMAN",490,"O60343","TBCD4_HUMAN","TBC1 domain family member 4",null,"TBC1D4"]
["18.6193","18.5764","19.2852","20.1686","17.5874","18.8015",{"$nulls":3},"actin filament organization;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;lamellipodium assembly;negative regulation of cell death;negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;negative regulation of peptidyl-serine phosphorylation;negative regulation of PERK-mediated unfolded protein response;negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;peptidyl-serine dephosphorylation;positive regulation of actin filament polymerization;positive regulation of cap-dependent translational initiation;positive regulation of cap-independent translational initiation;positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;positive regulation of neuron projection development;positive regulation of T cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of translation in response to endoplasmic reticulum stress;regulation of cell migration;response to other organism;signal complex assembly;substrate-dependent cell migration, cell extension;T cell activation;T cell receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway","cadherin binding;cytoskeletal adaptor activity;ephrin receptor binding;eukaryotic initiation factor eIF2 binding;protein binding, bridging;protein domain specific binding;protein kinase inhibitor activity;receptor binding;receptor signaling complex scaffold activity;receptor tyrosine kinase binding;SH3/SH2 adaptor activity","cell-cell junction;cytoplasm;cytosol;endoplasmic reticulum;nucleus;plasma membrane;protein phosphatase type 1 complex;ribosome;vesicle membrane","Axon guidance;ErbB signaling pathway;Pathogenic Escherichia coli infection;T cell receptor signaling pathway",null,null,5,5,4,"15.4","15.4","13.3","42.864",0,"10.854",114920000,13,"0.0107977",1,"-0.025547","-0.0327489","sp|P16333|NCK1_HUMAN;tr|C9J0K5|C9J0K5_HUMAN;tr|C9K098|C9K098_HUMAN;tr|C9JVV5|C9JVV5_HUMAN;tr|C9J869|C9J869_HUMAN;tr|H7C5C7|H7C5C7_HUMAN;tr|C9JAB9|C9JAB9_HUMAN;tr|E7ERP6|E7ERP6_HUMAN;tr|E9PEE2|E9PEE2_HUMAN;tr|E7EPF5|E7EPF5_HUMAN","sp|P16333|NCK1_HUMAN;tr|C9J0K5|C9J0K5_HUMAN;tr|C9K098|C9K098_HUMAN;tr|C9JVV5|C9JVV5_HUMAN;tr|C9J869|C9J869_HUMAN",1134,"P16333","NCK1_HUMAN","Cytoplasmic protein NCK1",null,"NCK1"]
["18.4805","16.5166","17.9675","17.3013","17.4853","18.2596",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity","nucleus",{"$nulls":3},6,6,4,"13.5","13.5","9.5","69.287",0,"7.6336",54346000,9,"0.0136722",1,"-0.0271702","-0.0413361","tr|J3QLK5|J3QLK5_HUMAN;tr|J3KRK0|J3KRK0_HUMAN;sp|Q86UE8|TLK2_HUMAN;tr|J3QS44|J3QS44_HUMAN;tr|J3KT82|J3KT82_HUMAN","tr|J3QLK5|J3QLK5_HUMAN;tr|J3KRK0|J3KRK0_HUMAN;sp|Q86UE8|TLK2_HUMAN",5590,"J3QLK5","J3QLK5_HUMAN",null,null,"TLK2"]
["27.5912","25.5752","27.5482","27.5987","25.9","27.3009",{"$nulls":3},"movement of cell or subcellular component;negative regulation of apoptotic process;negative regulation of axonogenesis;negative regulation of cell adhesion;positive regulation of axonogenesis;regulation of actin cytoskeleton reorganization;regulation of Rho protein signal transduction;regulation of small GTPase mediated signal transduction;semaphorin-plexin signaling pathway","GTPase activator activity;Rho GDP-dissociation inhibitor activity","cytoskeleton;cytosol;extracellular exosome","Neurotrophin signaling pathway;Vasopressin-regulated water reabsorption",null,null,12,12,12,"71.1","71.1","71.1","23.207",0,"323.31",11194000000,147,"0.0110447",1,"-0.0283451","-0.0334887","sp|P52565|GDIR1_HUMAN;tr|J3KTF8|J3KTF8_HUMAN;tr|J3QQX2|J3QQX2_HUMAN;tr|J3KRE2|J3KRE2_HUMAN;tr|J3KRY1|J3KRY1_HUMAN;tr|J3KS60|J3KS60_HUMAN","sp|P52565|GDIR1_HUMAN;tr|J3KTF8|J3KTF8_HUMAN;tr|J3QQX2|J3QQX2_HUMAN;tr|J3KRE2|J3KRE2_HUMAN;tr|J3KRY1|J3KRY1_HUMAN",1771,"P52565","GDIR1_HUMAN","Rho GDP-dissociation inhibitor 1","ho GDI 1","ARHGDIA"]
["22.4127","21.998","19.9652","21.5862","22.3167","20.5703",{"$nulls":3},"cellular response to estrogen stimulus;positive regulation of gene expression, epigenetic","RNA polymerase II transcription coactivator activity","nuclear chromatin",{"$nulls":3},7,7,7,"38.9","38.9","38.9","18.224",0,"13.359",294590000,13,"0.0117742",1,"-0.0324656","-0.0356721","tr|K7EIJ0|K7EIJ0_HUMAN;tr|K7ENL2|K7ENL2_HUMAN;tr|A6NG10|A6NG10_HUMAN;tr|K7EMC9|K7EMC9_HUMAN;sp|Q969T9|WBP2_HUMAN;tr|B4DFG2|B4DFG2_HUMAN;tr|K7EIN1|K7EIN1_HUMAN;tr|K7ESN4|K7ESN4_HUMAN;tr|K7EIK1|K7EIK1_HUMAN","tr|K7EIJ0|K7EIJ0_HUMAN;tr|K7ENL2|K7ENL2_HUMAN;tr|A6NG10|A6NG10_HUMAN;tr|K7EMC9|K7EMC9_HUMAN;sp|Q969T9|WBP2_HUMAN;tr|B4DFG2|B4DFG2_HUMAN",3769,"K7EIJ0","K7EIJ0_HUMAN",null,null,"WBP2"]
["19.3891",1,"17.3087","18.5255",1,"18.2711",{"$nulls":3},"apoptotic mitochondrial changes;positive regulation of apoptotic process;regulation of apoptotic process","DNA binding;electron-transferring-flavoprotein dehydrogenase activity;flavin adenine dinucleotide binding","cytoplasm;cytosol;extracellular space;integral component of membrane;lipid droplet;mitochondrial outer membrane;mitochondrion","p53 signaling pathway",null,null,3,3,3,"10.7","10.7","10.7","40.526",0,"7.656",54329000,6,"0.00130832",1,"-0.0329367","-0.00401066","sp|Q9BRQ8|AIFM2_HUMAN","sp|Q9BRQ8|AIFM2_HUMAN",4169,"Q9BRQ8","AIFM2_HUMAN","Apoptosis-inducing factor 2",null,"AIFM2"]
["14.7569","14.0312",1,"14.5308","14.3566",1,{"$nulls":4},"DNA binding;protein dimerization activity;RNA polymerase II transcription factor activity, sequence-specific DNA binding;zinc ion binding","cytoplasm;nucleoplasm",{"$nulls":3},12,12,12,"15.2","15.2","15.2","128.72",0,"33.017",126930000,22,"0.00170702",1,"-0.0331059","-0.00523049","sp|Q5SVZ6|ZMYM1_HUMAN;tr|Q5SVZ7|Q5SVZ7_HUMAN","sp|Q5SVZ6|ZMYM1_HUMAN",2851,"Q5SVZ6","ZMYM1_HUMAN","Zinc finger MYM-type protein 1",null,"ZMYM1"]
["23.6393","22.0775","23.0515","23.3907","22.3706","23.1107",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;neutrophil degranulation;retrograde vesicle-mediated transport, Golgi to ER;viral process","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;ficolin-1-rich granule membrane;Golgi apparatus;Golgi membrane;Golgi-associated vesicle;intracellular membrane-bounded organelle;membrane;plasma membrane;secretory granule membrane;tertiary granule membrane;transport vesicle",{"$nulls":3},32,32,32,"41.4","41.4","41.4","107.14",0,"323.31",4112700000,199,"0.0210626",1,"-0.0346018","-0.063174","sp|P53618|COPB_HUMAN;tr|E9PP73|E9PP73_HUMAN;tr|E9PP63|E9PP63_HUMAN;tr|E9PKQ1|E9PKQ1_HUMAN","sp|P53618|COPB_HUMAN",1801,"P53618","COPB_HUMAN","Coatomer subunit beta",null,"COPB1"]
["22.8853","21.3267","22.1096","22.8959","21.3054","22.2292",{"$nulls":3},"regulation of translational initiation;translational initiation","cadherin binding;GTP binding;GTPase activity;RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;cytosol;plasma membrane","RNA transport",null,null,13,13,13,"32.5","32.5","32.5","49.222",0,"45.76",1294300000,86,"0.0187417",1,"-0.036307","-0.0563526","sp|P55010|IF5_HUMAN;tr|H0YLZ1|H0YLZ1_HUMAN;tr|H0YN40|H0YN40_HUMAN;tr|H0YMJ8|H0YMJ8_HUMAN;tr|H0YM54|H0YM54_HUMAN;tr|H0YK11|H0YK11_HUMAN;tr|H0YK29|H0YK29_HUMAN","sp|P55010|IF5_HUMAN;tr|H0YLZ1|H0YLZ1_HUMAN;tr|H0YN40|H0YN40_HUMAN",1830,"P55010","IF5_HUMAN","Eukaryotic translation initiation factor 5","IF-5","EIF5"]
["20.5544","19.2767","20.015","20.563","18.5634","20.8372",{"$nulls":3},"transcription, DNA-templated","DNA binding transcription factor activity;sequence-specific DNA binding","endoplasmic reticulum;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},5,5,5,"17.1","17.1","17.1","58.683",0,"30.308",132200000,18,"0.0161056",1,"-0.0391744","-0.0485642","tr|A0A0C4DG88|A0A0C4DG88_HUMAN;sp|P14859|PO2F1_HUMAN;tr|U3KQN1|U3KQN1_HUMAN;tr|U3KQ96|U3KQ96_HUMAN;tr|H0YNW1|H0YNW1_HUMAN;sp|Q9UKI9|PO2F3_HUMAN;sp|P09086|PO2F2_HUMAN;tr|H0YLL6|H0YLL6_HUMAN;tr|B5ME60|B5ME60_HUMAN;tr|A0A0A0MT46|A0A0A0MT46_HUMAN;tr|H0YKT2|H0YKT2_HUMAN;tr|H0YLC5|H0YLC5_HUMAN","tr|A0A0C4DG88|A0A0C4DG88_HUMAN;sp|P14859|PO2F1_HUMAN",1108,"A0A0C4DG88","A0A0C4DG88_HUMAN","POU domain protein {ECO:0000256|RuleBase:RU361194}",null,"POU2F1"]
["19.2002","17.3655","17.3437","19.0963","17.2271","17.7167",{"$nulls":3},"blastocyst growth;cellular response to lipopolysaccharide;endodermal cell fate commitment;histone H2B ubiquitination;histone H3-K4 trimethylation;histone monoubiquitination;inner cell mass cell differentiation;interleukin-6-mediated signaling pathway;JAK-STAT cascade;negative regulation of mRNA polyadenylation;negative regulation of myeloid cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of histone H2B ubiquitination;positive regulation of histone H3-K4 methylation;positive regulation of histone H3-K79 methylation;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein ubiquitination;regulation of genetic imprinting;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;trophectodermal cell differentiation;Wnt signaling pathway","RNA polymerase II core binding;SH2 domain binding","Cdc73/Paf1 complex;nuclear speck;nucleoplasm;transcriptionally active chromatin",{"$nulls":3},21,21,21,27,27,27,"133.5",0,"74.553",463320000,51,"0.0174075",1,"-0.0435937","-0.0524162","sp|Q6PD62|CTR9_HUMAN;tr|H0YCE8|H0YCE8_HUMAN","sp|Q6PD62|CTR9_HUMAN",3026,"Q6PD62","CTR9_HUMAN","RNA polymerase-associated protein CTR9 homolog",null,"CTR9"]
["21.0173","19.3797","19.6718","20.7794","19.601","19.8203",{"$nulls":3},"axo-dendritic transport","kinesin binding;microtubule binding;microtubule motor activity","ciliary rootlet;cytoplasm;kinesin complex;microtubule;motile cilium;neuron projection","Salmonella infection",null,null,15,14,13,"41.5","38.7","37.1","55.364",0,"51.257",335960000,32,"0.0236792",1,"-0.0439599","-0.0708254","sp|Q6P597|KLC3_HUMAN;tr|K7EL76|K7EL76_HUMAN;tr|K7ENJ3|K7ENJ3_HUMAN;tr|K7ELP9|K7ELP9_HUMAN","sp|Q6P597|KLC3_HUMAN;tr|K7EL76|K7EL76_HUMAN;tr|K7ENJ3|K7ENJ3_HUMAN",3016,"Q6P597","KLC3_HUMAN","Kinesin light chain 3",null,"KLC3"]
["22.9453","21.3081","21.1385","22.0732","21.4341","22.0219",{"$nulls":3},"positive regulation of gene expression, epigenetic;positive regulation of type I interferon production;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription from RNA polymerase I promoter;transcription from RNA polymerase III promoter;transcription initiation from RNA polymerase I promoter","DNA binding;DNA-directed 5'-3' RNA polymerase activity;protein dimerization activity","cytosol;DNA-directed RNA polymerase I complex;DNA-directed RNA polymerase III complex;nucleoplasm;nucleus","Cytosolic DNA-sensing pathway;RNA polymerase",null,null,11,11,11,"47.1","47.1","47.1","39.249",0,"127.21",1097500000,100,"0.0250592",1,"-0.0457649","-0.0748443","sp|O15160|RPAC1_HUMAN;tr|E7EQB9|E7EQB9_HUMAN;tr|D6RDJ3|D6RDJ3_HUMAN;tr|H0Y723|H0Y723_HUMAN","sp|O15160|RPAC1_HUMAN;tr|E7EQB9|E7EQB9_HUMAN",341,"O15160","RPAC1_HUMAN","DNA-directed RNA polymerases I and III subunit RPAC1","NA polymerases I and III subunit AC1;NA-directed RNA polymerase I subunit C","POLR1C"]
["19.4255","17.8382","19.8129","19.2127","18.1728","19.8289",{"$nulls":3},"anterograde axonal transport;antigen processing and presentation of exogenous peptide antigen via MHC class II;microtubule-based movement;mitotic cytokinesis;mitotic spindle midzone assembly;organelle organization;retrograde vesicle-mediated transport, Golgi to ER","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;DNA binding;microtubule binding;microtubule motor activity","axon cytoplasm;chromosome;cytoplasm;cytosol;intercellular bridge;kinesin complex;membrane;midbody;nuclear matrix;nucleoplasm;spindle microtubule",{"$nulls":3},16,16,15,18,18,"17.1","139.88",0,"59.067",407160000,49,"0.0197666",1,"-0.045929","-0.059369","sp|O95239|KIF4A_HUMAN;sp|Q2VIQ3|KIF4B_HUMAN;tr|Q5JRK0|Q5JRK0_HUMAN","sp|O95239|KIF4A_HUMAN",729,"O95239","KIF4A_HUMAN","Chromosome-associated kinesin KIF4A",null,"KIF4A"]
["19.6601","19.5151","18.6948","19.5498","19.3906","19.0676",{"$nulls":3},"blastocyst growth;endodermal cell fate commitment;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of histone H3-K4 methylation;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein ubiquitination;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;Wnt signaling pathway","RNA binding;RNA polymerase II C-terminal domain phosphoserine binding;single-stranded DNA binding;transcription factor activity, RNA polymerase II transcription factor binding","Cdc73/Paf1 complex;nucleolus;nucleoplasm",{"$nulls":3},12,12,12,"18.9","18.9","18.9","80.313",0,"44.818",291470000,21,"0.0474026",1,"-0.0460027","-0.13842","sp|Q92541|RTF1_HUMAN;tr|H0YKX1|H0YKX1_HUMAN","sp|Q92541|RTF1_HUMAN;tr|H0YKX1|H0YKX1_HUMAN",3674,"Q92541","RTF1_HUMAN","RNA polymerase-associated protein RTF1 homolog",null,"RTF1"]
["22.7092","20.7742","22.6285","23.1712","20.4473","22.6356",{"$nulls":3},"carbohydrate metabolic process;malate metabolic process;NADP biosynthetic process;protein tetramerization;pyruvate metabolic process;regulation of lipid metabolic process;regulation of NADP metabolic process;response to carbohydrate;response to hormone","ADP binding;electron transfer activity;malate dehydrogenase (decarboxylating) (NAD+) activity;malate dehydrogenase (decarboxylating) (NADP+) activity;malic enzyme activity;manganese ion binding;NAD binding;NADP binding;oxaloacetate decarboxylase activity","cytosol;mitochondrion","Carbon metabolism;Metabolic pathways;PPAR signaling pathway;Pyruvate metabolism",null,null,17,17,17,"45.3","45.3","45.3","64.149",0,"322.13",1446600000,91,"0.0150203",1,"-0.0474192","-0.0453451","sp|P48163|MAOX_HUMAN","sp|P48163|MAOX_HUMAN",1622,"P48163","MAOX_HUMAN","NADP-dependent malic enzyme","ADP-ME","ME1"]
["15.819","14.7074","14.9405","16.7711","13.8655","14.9759",{"$nulls":3},"regulation of translational initiation;viral process","RNA binding;RNA cap binding;translation factor activity, RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 4F complex","RNA transport;Viral myocarditis",null,null,7,5,5,"4.9","3.8","3.8","176.65",0,"11.061",48371000,8,"0.0177022",1,"-0.0485776","-0.0532865","sp|O43432|IF4G3_HUMAN;tr|A0A0A0MSA7|A0A0A0MSA7_HUMAN","sp|O43432|IF4G3_HUMAN;tr|A0A0A0MSA7|A0A0A0MSA7_HUMAN",421,"O43432","IF4G3_HUMAN","Eukaryotic translation initiation factor 4 gamma 3","IF4G 3;IF-4G 3;IF-4-gamma 3","EIF4G3"]
["17.4964","18.6309","18.1447","18.3836","18.0125","18.0289",{"$nulls":3},"establishment of protein localization;microtubule cytoskeleton organization;negative regulation of focal adhesion assembly;negative regulation of stress fiber assembly;negative regulation of wound healing, spreading of epidermal cells;positive regulation of basement membrane assembly involved in embryonic body morphogenesis;regulation of epithelial to mesenchymal transition;regulation of gastrulation;regulation of microtubule cytoskeleton organization","cadherin binding","basal cortex;cell leading edge;cytosol;intermediate filament cytoskeleton;plasma membrane",{"$nulls":3},33,33,33,38,38,38,"142.16",0,"194.84",1274100000,136,"0.0499407",1,"-0.0509466","-0.145474","sp|Q86SQ0|PHLB2_HUMAN;tr|E9PFQ4|E9PFQ4_HUMAN;tr|E9PGF6|E9PGF6_HUMAN;tr|G5E9V3|G5E9V3_HUMAN;tr|E9PDY7|E9PDY7_HUMAN","sp|Q86SQ0|PHLB2_HUMAN;tr|E9PFQ4|E9PFQ4_HUMAN;tr|E9PGF6|E9PGF6_HUMAN",3204,"Q86SQ0","PHLB2_HUMAN","Pleckstrin homology-like domain family B member 2",null,"PHLDB2"]
["20.5863","18.2209","19.9909","20.905","18.2428","19.8086",{"$nulls":3},"base-excision repair;base-excision repair, AP site formation via deaminated base removal;depyrimidination;DNA repair;negative regulation of apoptotic process;positive regulation of isotype switching;somatic hypermutation of immunoglobulin genes;somatic recombination of immunoglobulin gene segments;viral process","damaged DNA binding;ribosomal small subunit binding;uracil DNA N-glycosylase activity","nucleoplasm;nucleus","Base excision repair;Primary immunodeficiency",null,null,7,7,7,"34.5","34.5","34.5","34.645",0,"22.994",129550000,21,"0.0166923",1,"-0.0527884","-0.0503013","sp|P13051|UNG_HUMAN;tr|F5GYA2|F5GYA2_HUMAN;tr|Q68DM5|Q68DM5_HUMAN","sp|P13051|UNG_HUMAN;tr|F5GYA2|F5GYA2_HUMAN;tr|Q68DM5|Q68DM5_HUMAN",1075,"P13051","UNG_HUMAN","Uracil-DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_03166}","DG {ECO:0000255|HAMAP-Rule:MF_03166}","UNG"]
["30.0799","29.1329","29.8581","30.133","29.1589","29.9418",{"$nulls":3},"cellular response to drug;cellular response to interleukin-4;cellular response to organic cyclic compound;chaperone-mediated protein complex assembly;Fc-gamma receptor signaling pathway involved in phagocytosis;negative regulation of cell cycle arrest;negative regulation of complement-dependent cytotoxicity;negative regulation of neuron apoptotic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of transforming growth factor beta activation;neutrophil degranulation;placenta development;positive regulation of cell differentiation;positive regulation of cell size;positive regulation of nitric oxide biosynthetic process;positive regulation of phosphoprotein phosphatase activity;positive regulation of protein binding;positive regulation of protein import into nucleus, translocation;positive regulation of protein localization to cell surface;positive regulation of protein serine/threonine kinase activity;positive regulation of telomerase activity;positive regulation of transforming growth factor beta receptor signaling pathway;protein folding;protein stabilization;regulation of cellular response to heat;regulation of interferon-gamma-mediated signaling pathway;regulation of protein ubiquitination;regulation of type I interferon-mediated signaling pathway;response to cocaine;response to salt stress;response to unfolded protein;supramolecular fiber organization;telomerase holoenzyme complex assembly;telomere maintenance via telomerase;virion attachment to host cell;xenobiotic metabolic process","ATP binding;ATP-dependent protein binding;cadherin binding;CTP binding;dATP binding;disordered domain specific binding;DNA polymerase binding;double-stranded RNA binding;drug binding;GTP binding;heat shock protein binding;histone deacetylase binding;histone methyltransferase binding;identical protein binding;ion channel binding;kinase binding;MHC class II protein complex binding;nitric-oxide synthase regulator activity;peptide binding;protein dimerization activity;protein homodimerization activity;protein kinase binding;protein kinase regulator activity;RNA binding;sulfonylurea receptor binding;TPR domain binding;unfolded protein binding;UTP binding","apical plasma membrane;aryl hydrocarbon receptor complex;basolateral plasma membrane;brush border membrane;cell surface;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;inclusion body;lysosomal membrane;melanosome;membrane;mitochondrion;nucleoplasm;nucleus;ooplasm;protein complex;secretory granule lumen;sperm head plasma membrane","Antigen processing and presentation;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;IL-17 signaling pathway;Necroptosis;NOD-like receptor signaling pathway;Pathways in cancer;PI3K-Akt signaling pathway;Progesterone-mediated oocyte maturation;Prostate cancer;Protein processing in endoplasmic reticulum;Th17 cell differentiation",null,null,52,52,32,"71.3","71.3","43.4","83.263",0,"323.31",{"v":3072900000000000,"d":"3.07E+15"},2429,"0.0448725",1,"-0.0542488","-0.131356","sp|P08238|HS90B_HUMAN;sp|Q58FF7|H90B3_HUMAN","sp|P08238|HS90B_HUMAN",960,"P08238","HS90B_HUMAN","Heat shock protein HSP 90-beta","SP 90","HSP90AB1"]
["16.9641","14.9648","16.2752","17.0465","15.3573","15.9637",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell proliferation;centrosome cycle;ciliary basal body-plasma membrane docking;establishment of protein localization;female meiosis chromosome segregation;G2/M transition of mitotic cell cycle;homologous chromosome segregation;microtubule bundle formation;mitotic cell cycle;mitotic cytokinesis;mitotic nuclear envelope disassembly;mitotic sister chromatid segregation;mitotic spindle assembly checkpoint;negative regulation of apoptotic process;negative regulation of cyclin-dependent protein serine/threonine kinase activity;negative regulation of transcription from RNA polymerase II promoter;nuclear envelope disassembly;peptidyl-serine phosphorylation;positive regulation of peptidyl-threonine phosphorylation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein localization to nucleus;positive regulation of proteolysis;positive regulation of ubiquitin protein ligase activity;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;positive regulation of ubiquitin-protein transferase activity;protein destabilization;protein localization to chromatin;protein localization to nuclear envelope;protein phosphorylation;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of cell cycle;regulation of cell cycle G2/M phase transition;regulation of cytokinesis;regulation of G2/M transition of mitotic cell cycle;regulation of mitotic cell cycle;regulation of mitotic metaphase/anaphase transition;regulation of mitotic spindle assembly;regulation of protein binding;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;signal transduction involved in G2 DNA damage checkpoint;sister chromatid cohesion;synaptonemal complex disassembly","anaphase-promoting complex binding;ATP binding;identical protein binding;kinase activity;magnesium ion binding;microtubule binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity","centrosome;chromatin;condensed nuclear chromosome outer kinetochore;cytosol;kinetochore;microtubule cytoskeleton;midbody;nucleoplasm;nucleus;spindle;spindle midzone;spindle pole;synaptonemal complex","Cell cycle;FoxO signaling pathway;Oocyte meiosis;Progesterone-mediated oocyte maturation",null,null,3,3,3,"6.8","6.8","6.8","68.254",0,"6.6182",45466000,6,"0.0237646",1,"-0.0544974","-0.0710744","sp|P53350|PLK1_HUMAN;tr|I3L387|I3L387_HUMAN","sp|P53350|PLK1_HUMAN",1792,"P53350","PLK1_HUMAN","Serine/threonine-protein kinase PLK1",null,"PLK1"]
["19.5449","19.3701","18.8839","19.3393","18.9211","19.7063",{"$nulls":3},"I-kappaB phosphorylation;multicellular organism development;negative regulation of apoptotic process;positive regulation of NF-kappaB transcription factor activity;protein transport;regulation of transcription, DNA-templated;retrograde transport, endosome to Golgi","cadherin binding;leucine zipper domain binding;PDZ domain binding;Rab GTPase binding","cytoplasm;Golgi membrane;IkappaB kinase complex;presynaptic active zone;presynaptic membrane;synapse","NF-kappa B signaling pathway",null,null,15,15,14,"17.9","17.9","16.8","128.08",0,"76.665",429420000,24,"0.0647049",1,"-0.0559406","-0.185887","sp|Q8IUD2|RB6I2_HUMAN;tr|X6RLX0|X6RLX0_HUMAN;tr|G8JLD3|G8JLD3_HUMAN;tr|X6RM00|X6RM00_HUMAN;tr|K7EPP6|K7EPP6_HUMAN;tr|K7EPD6|K7EPD6_HUMAN;tr|K7EP25|K7EP25_HUMAN","sp|Q8IUD2|RB6I2_HUMAN;tr|X6RLX0|X6RLX0_HUMAN;tr|G8JLD3|G8JLD3_HUMAN;tr|X6RM00|X6RM00_HUMAN",3276,"Q8IUD2","RB6I2_HUMAN","ELKS/Rab6-interacting/CAST family member 1","RC-1","ERC1"]
["20.6817","19.8192","19.6726","20.2544","18.7566","21.3315",{"$nulls":3},"layer formation in cerebral cortex;phosphatidylinositol acyl-chain remodeling;phospholipid biosynthetic process;ventricular system development","1-acylglycerol-3-phosphate O-acyltransferase activity;2-acylglycerol-3-phosphate O-acyltransferase activity;lysophospholipid acyltransferase activity","endoplasmic reticulum membrane;integral component of membrane;membrane","Glycerophospholipid metabolism",null,null,6,6,6,"19.3","19.3","19.3","52.764",0,"38.23",394390000,31,"0.0232287",1,"-0.0563234","-0.069511","sp|Q96N66|MBOA7_HUMAN;tr|A9C4B8|A9C4B8_HUMAN;tr|M0R1Z5|M0R1Z5_HUMAN;tr|H7C2M4|H7C2M4_HUMAN;tr|C9J4E9|C9J4E9_HUMAN;tr|A0A0G2JNX6|A0A0G2JNX6_HUMAN","sp|Q96N66|MBOA7_HUMAN;tr|A9C4B8|A9C4B8_HUMAN",3980,"Q96N66","MBOA7_HUMAN","Lysophospholipid acyltransferase 7 {ECO:0000305}","PLAT 7 {ECO:0000305}","MBOAT7"]
["22.1998","21.4994","22.0526","22.9533","21.1786","21.7952",{"$nulls":3},"apoptotic process;mRNA splicing, via spliceosome;RNA splicing, via transesterification reactions","RNA binding","Cajal body;cytoplasm;nuclear speck;nucleoplasm;nucleus;spliceosomal complex","Spliceosome",null,null,6,6,6,"36.6","36.6","36.6","26.711",0,"66.664",574330000,53,"0.0351699",1,"-0.0584431","-0.103953","sp|O75940|SPF30_HUMAN","sp|O75940|SPF30_HUMAN",654,"O75940","SPF30_HUMAN","Survival of motor neuron-related-splicing factor 30",null,"SMNDC1"]
["16.6327","15.9696","17.6041","16.0119","16.6261","17.7481",{"$nulls":3},"activation of MAPKK activity;axon guidance;calcium-mediated signaling;cell migration;cellular response to epidermal growth factor stimulus;epidermal growth factor receptor signaling pathway;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;in utero embryonic development;inositol phosphate metabolic process;leukocyte migration;phospholipid catabolic process;positive regulation of angiogenesis;positive regulation of blood vessel endothelial cell migration;positive regulation of epithelial cell migration;positive regulation of release of sequestered calcium ion into cytosol;signal transduction;T cell receptor signaling pathway;viral process","calcium ion binding;glutamate receptor binding;neurotrophin TRKA receptor binding;phosphatidylinositol phospholipase C activity;phospholipase C activity;protein kinase binding;receptor tyrosine kinase binding;signal transducer activity, downstream of receptor","cell projection;cell-cell junction;COP9 signalosome;cytoplasm;cytosol;lamellipodium;plasma membrane;ruffle","AGE-RAGE signaling pathway in diabetic complications;Axon guidance;Calcium signaling pathway;Choline metabolism in cancer;EGFR tyrosine kinase inhibitor resistance;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glioma;Hepatocellular carcinoma;HIF-1 signaling pathway;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Inositol phosphate metabolism;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Metabolic pathways;MicroRNAs in cancer;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;NF-kappa B signaling pathway;Non-small cell lung cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid hormone signaling pathway;VEGF signaling pathway;Vibrio cholerae infection;Yersinia infection",null,null,4,4,4,"4.6","4.6","4.6","148.53",0,"8.6564",87656000,10,"0.028957",1,"-0.0599022","-0.0861352","sp|P19174|PLCG1_HUMAN","sp|P19174|PLCG1_HUMAN",1188,"P19174","PLCG1_HUMAN","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1",null,"PLCG1"]
["29.8241","28.8082","29.3168","29.8605","28.7739","29.4994",{"$nulls":3},"canonical glycolysis;gluconeogenesis;negative regulation of cell growth;negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of ATP biosynthetic process;positive regulation of muscle contraction;positive regulation of plasminogen activation;response to virus;transcription, DNA-templated","cadherin binding;GTPase binding;magnesium ion binding;phosphopyruvate hydratase activity;protein homodimerization activity;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cell cortex region;cell surface;cytoplasm;cytosol;extracellular exosome;extracellular space;M band;membrane;nucleus;phosphopyruvate hydratase complex;plasma membrane","Biosynthesis of amino acids;Carbon metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;RNA degradation",null,null,30,30,27,"78.8","78.8","70.3","47.168",0,"323.31",152900000000000,1607,"0.0486478",1,"-0.0615368","-0.141885","sp|P06733|ENOA_HUMAN;tr|K7EM90|K7EM90_HUMAN","sp|P06733|ENOA_HUMAN",918,"P06733","ENOA_HUMAN","Alpha-enolase",null,"ENO1"]
["22.7679","21.9213","22.5368","23.0809","21.7824","22.5545",{"$nulls":4},"ATP binding;nucleic acid binding",{"$nulls":4},20,20,0,"53.2","53.2",0,"54.017",0,"240.4",1630300000,77,"0.0482786",1,"-0.0639337","-0.140859","tr|F6QDS0|F6QDS0_HUMAN;tr|I3L352|I3L352_HUMAN;tr|H0YD26|H0YD26_HUMAN;tr|E9PR46|E9PR46_HUMAN;tr|J3QL17|J3QL17_HUMAN;sp|Q9UHL0|DDX25_HUMAN","tr|F6QDS0|F6QDS0_HUMAN;tr|I3L352|I3L352_HUMAN",5532,"F6QDS0","F6QDS0_HUMAN"]
["24.1298","22.629","23.775","24.3873","22.4657","23.8765",{"$nulls":3},"cell proliferation;cellular response to DNA damage stimulus;cellular response to epidermal growth factor stimulus;cellular response to xenobiotic stimulus;DNA replication;DNA replication initiation;DNA unwinding involved in DNA replication;G1/S transition of mitotic cell cycle;regulation of phosphorylation;response to drug","ATP binding;DNA helicase activity;single-stranded DNA binding","chromatin;cytosol;MCM complex;membrane;nuclear chromosome, telomeric region;nucleoplasm;nucleus","Cell cycle;DNA replication",null,null,33,33,33,"52.3","52.3","52.3","81.307",0,"323.31",4799000000,244,"0.0300013",1,"-0.0652224","-0.0891452","sp|P33993|MCM7_HUMAN;tr|C9J8M6|C9J8M6_HUMAN","sp|P33993|MCM7_HUMAN",1439,"P33993","MCM7_HUMAN","DNA replication licensing factor MCM7",null,"MCM7"]
["18.7926","18.0056","18.2317","18.9187","17.9685","18.3409",{"$nulls":3},"actin cytoskeleton organization;apical constriction;bleb assembly;cortical actin cytoskeleton organization;ephrin receptor signaling pathway;execution phase of apoptosis;G-protein coupled receptor signaling pathway;I-kappaB kinase/NF-kappaB signaling;leukocyte cell-cell adhesion;leukocyte migration;leukocyte tethering or rolling;membrane to membrane docking;myoblast migration;negative regulation of angiogenesis;negative regulation of bicellular tight junction assembly;negative regulation of myosin-light-chain-phosphatase activity;negative regulation of neuron apoptotic process;negative regulation of protein binding;neutrophil degranulation;positive regulation of focal adhesion assembly;protein localization to plasma membrane;protein phosphorylation;regulation of actin cytoskeleton organization;regulation of cell adhesion;regulation of cell motility;regulation of establishment of cell polarity;regulation of establishment of endothelial barrier;regulation of focal adhesion assembly;regulation of keratinocyte differentiation;regulation of stress fiber assembly;Rho protein signal transduction;signal transduction;smooth muscle contraction;vascular endothelial growth factor receptor signaling pathway","ATP binding;GTP-Rho binding;metal ion binding;protein kinase activity;protein serine/threonine kinase activity","bleb;centriole;cytoskeleton;cytosol;extracellular region;Golgi membrane;lamellipodium;plasma membrane;ruffle;secretory granule lumen","Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Focal adhesion;Human cytomegalovirus infection;Leukocyte transendothelial migration;MicroRNAs in cancer;Oxytocin signaling pathway;Pathogenic Escherichia coli infection;Pathways in cancer;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis;Sphingolipid signaling pathway;TGF-beta signaling pathway;Tight junction;Vascular smooth muscle contraction;Yersinia infection",null,null,20,17,17,"20.2","17.4","17.4","158.17",0,"44.627",442550000,31,"0.0634154",1,"-0.0660496","-0.182399","sp|Q13464|ROCK1_HUMAN;tr|J3KRH6|J3KRH6_HUMAN","sp|Q13464|ROCK1_HUMAN",2365,"Q13464","ROCK1_HUMAN","Rho-associated protein kinase 1",null,"ROCK1"]
["22.8823","21.8298","23.3557","23.001","21.8929","23.3838",{"$nulls":3},"cilium assembly;intraciliary transport;kidney development;mitotic cytokinesis;photoreceptor cell development;post-Golgi vesicle-mediated transport;small GTPase mediated signal transduction;smoothened signaling pathway","GDP binding;GTP binding;GTPase activity;metal ion binding;microtubule binding","centrosome;cilium;cytoplasmic microtubule;extracellular exosome;Golgi apparatus;Golgi membrane;midbody;nucleus;photoreceptor connecting cilium;spindle microtubule",{"$nulls":3},9,9,9,"54.9","54.9","54.9","20.455",0,"113.77",815580000,41,"0.0373528",1,"-0.0699482","-0.110162","sp|P36405|ARL3_HUMAN","sp|P36405|ARL3_HUMAN",1479,"P36405","ARL3_HUMAN","ADP-ribosylation factor-like protein 3",null,"ARL3"]
["21.3652","19.8967","20.7241","21.2061","19.7936","21.1963",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein ubiquitination;osteoblast differentiation;positive regulation of cell proliferation;positive regulation of glial cell proliferation;protein K69-linked ufmylation;protein ufmylation;regulation of intracellular estrogen receptor signaling pathway;regulation of proteasomal ubiquitin-dependent protein catabolic process;regulation of protein localization;response to endoplasmic reticulum stress;response to L-glutamate","ligase activity;UFM1 transferase activity","cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;membrane;neuron projection;protein complex",{"$nulls":3},33,33,32,"50.8","50.8","49.9","89.594",0,"240.68",4502000000,343,"0.0374957",1,"-0.0700016","-0.110567","sp|O94874|UFL1_HUMAN","sp|O94874|UFL1_HUMAN",683,"O94874","UFL1_HUMAN","E3 UFM1-protein ligase 1 {ECO:0000305}",null,"UFL1"]
["18.5376","16.7502","14.9814","16.6926","16.7916","16.9957",{"$nulls":3},"cleavage involved in rRNA processing;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosomal small subunit biogenesis;rRNA processing","RNA binding","90S preribosome;nucleolus;nucleoplasm;nucleus",{"$nulls":3},7,7,7,29,29,29,"29.823",0,"32.769",268420000,21,"0.0227654",1,"-0.0702346","-0.068158","sp|Q96EU6|RRP36_HUMAN;tr|U3KPZ9|U3KPZ9_HUMAN;tr|C9J4X5|C9J4X5_HUMAN;sp|Q9H160|ING2_HUMAN","sp|Q96EU6|RRP36_HUMAN",3864,"Q96EU6","RRP36_HUMAN","Ribosomal RNA processing protein 36 homolog",null,"RRP36"]
["19.5786","19.9611","19.935","20.7793","18.7757","20.1328",{"$nulls":3},"actin cytoskeleton organization;axon guidance;ossification;positive regulation of osteoblast differentiation;receptor-mediated endocytosis","metal ion binding","actin cytoskeleton;cell-cell adherens junction;cytosol;focal adhesion;nucleus;ruffle;stress fiber",{"$nulls":3},11,11,11,"43.8","43.8","43.8","49.844",0,"32.223",335520000,34,"0.0400532",1,"-0.0710545","-0.117807","sp|Q9NR12|PDLI7_HUMAN;tr|D6RF83|D6RF83_HUMAN;tr|D6RH06|D6RH06_HUMAN;tr|H7BYK4|H7BYK4_HUMAN;tr|D6RAN1|D6RAN1_HUMAN;tr|H0Y8W6|H0Y8W6_HUMAN","sp|Q9NR12|PDLI7_HUMAN;tr|D6RF83|D6RF83_HUMAN;tr|D6RH06|D6RH06_HUMAN",4673,"Q9NR12","PDLI7_HUMAN","PDZ and LIM domain protein 7",null,"PDLIM7"]
["25.1565","24.464","24.8668","25.3106","24.5177","24.8768",{"$nulls":3},"androgen receptor signaling pathway;chaperone-mediated protein folding;copper ion transport;embryo implantation;male sex differentiation;negative regulation of microtubule polymerization;negative regulation of microtubule polymerization or depolymerization;negative regulation of neuron projection development;prostate gland development;protein complex localization;protein folding;regulation of cellular response to heat;steroid hormone receptor complex assembly","ATP binding;copper-dependent protein binding;FK506 binding;glucocorticoid receptor binding;GTP binding;heat shock protein binding;peptidyl-prolyl cis-trans isomerase activity;phosphoprotein binding;protein binding, bridging;RNA binding;tau protein binding","axonal growth cone;cytoplasm;cytosol;extracellular exosome;microtubule;mitochondrion;neuronal cell body;nucleoplasm;perinuclear region of cytoplasm;protein complex","Estrogen signaling pathway",null,null,30,30,30,"68.8","68.8","68.8","51.804",0,"323.31",10898000000,349,"0.0843954",1,"-0.0726051","-0.238259","sp|Q02790|FKBP4_HUMAN;tr|F5H1U3|F5H1U3_HUMAN;tr|H0YFG2|H0YFG2_HUMAN;tr|F5H120|F5H120_HUMAN","sp|Q02790|FKBP4_HUMAN",2162,"Q02790","FKBP4_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP4","PIase FKBP4","FKBP4"]
["22.81","22.0416","22.0942","23.2646","21.9399","21.9662",{"$nulls":3},"cell division;G2/M transition of mitotic cell cycle;mitotic cell cycle;negative regulation of protein dephosphorylation;positive regulation of gluconeogenesis;positive regulation of glucose import","phosphatase inhibitor activity;potassium channel regulator activity;protein phosphatase 2A binding;protein phosphatase inhibitor activity;protein phosphatase regulator activity;receptor binding","cytoplasm;nucleoplasm",{"$nulls":3},5,4,4,"52.7","42.9","42.9","12.323",0,"18.527",399290000,27,"0.0512643",1,"-0.0749563","-0.14914","sp|P56211|ARP19_HUMAN;tr|H3BMD8|H3BMD8_HUMAN;tr|H3BQ52|H3BQ52_HUMAN;tr|H3BTD3|H3BTD3_HUMAN","sp|P56211|ARP19_HUMAN;tr|H3BMD8|H3BMD8_HUMAN;tr|H3BQ52|H3BQ52_HUMAN;tr|H3BTD3|H3BTD3_HUMAN",1862,"P56211","ARP19_HUMAN","cAMP-regulated phosphoprotein 19","RPP-19","ARPP19"]
["19.9309","18.5071","19.2199","20.2826","18.321","19.2821",{"$nulls":3},"actin cytoskeleton organization;cell projection assembly;cerebral cortex GABAergic interneuron development;homeostasis of number of cells within a tissue;intracellular signal transduction;neuromuscular process controlling balance;neuron projection development;positive regulation of cell adhesion mediated by integrin;positive regulation of substrate adhesion-dependent cell spreading;regulation of neuron maturation;regulation of small GTPase mediated signal transduction;small GTPase mediated signal transduction;synaptic transmission, GABAergic","calcium-dependent protein binding;GTP binding;GTPase activity","cell periphery;cytosol;endomembrane system;extracellular exosome;filamentous actin;growth cone;lamellipodium;neuron projection;neuronal cell body;perinuclear region of cytoplasm;plasma membrane","Adherens junction;Axon guidance;B cell receptor signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Choline metabolism in cancer;Colorectal cancer;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;Pancreatic cancer;Pathways in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Sphingolipid signaling pathway;VEGF signaling pathway;Viral myocarditis;Wnt signaling pathway;Yersinia infection",null,null,5,1,1,"30.2","7.3","7.3","21.379","0.0013661","3.2273",51183000,6,"0.036784",1,"-0.0759557","-0.108546","sp|P60763|RAC3_HUMAN;tr|J3KSC4|J3KSC4_HUMAN;tr|J3QLK0|J3QLK0_HUMAN","sp|P60763|RAC3_HUMAN;tr|J3KSC4|J3KSC4_HUMAN;tr|J3QLK0|J3QLK0_HUMAN",1898,"P60763","RAC3_HUMAN","Ras-related C3 botulinum toxin substrate 3",null,"RAC3"]
["26.3319","25.4473","26.0614","26.3251","25.6348","26.1093",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;neutrophil degranulation;pore complex assembly;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;toxin transport","ATP binding;ATPase activity, coupled;cadherin binding;protein binding involved in protein folding;unfolded protein binding","azurophil granule lumen;cell body;centrosome;chaperonin-containing T-complex;cilium;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intermediate filament cytoskeleton;microtubule;nucleoplasm;secretory granule lumen;zona pellucida receptor complex",{"$nulls":3},35,35,35,"69.7","69.7","69.7","59.62",0,"323.31",26327000000,575,"0.0810851",1,"-0.0761598","-0.229569","sp|P50990|TCPQ_HUMAN;tr|H7C4C8|H7C4C8_HUMAN;tr|H7C2U0|H7C2U0_HUMAN","sp|P50990|TCPQ_HUMAN",1723,"P50990","TCPQ_HUMAN","T-complex protein 1 subunit theta","CP-1-theta","CCT8"]
["20.6795","17.9748","19.9861","21.4182","18.1459","19.3137",{"$nulls":5},"cytosol;nucleoplasm;plasma membrane",{"$nulls":3},20,20,20,"32.9","32.9","32.9","92.407",0,"164.89",500430000,56,"0.0210309",1,"-0.0791556","-0.0630811","tr|H7BXH2|H7BXH2_HUMAN;tr|E9PKF6|E9PKF6_HUMAN;sp|Q5H9R7|PP6R3_HUMAN;tr|E9PQP7|E9PQP7_HUMAN;tr|H0YEN2|H0YEN2_HUMAN;tr|E9PK08|E9PK08_HUMAN;tr|E9PNN8|E9PNN8_HUMAN;tr|H0YDW1|H0YDW1_HUMAN;tr|E9PJD8|E9PJD8_HUMAN;tr|E9PKG4|E9PKG4_HUMAN","tr|H7BXH2|H7BXH2_HUMAN;tr|E9PKF6|E9PKF6_HUMAN;sp|Q5H9R7|PP6R3_HUMAN;tr|E9PQP7|E9PQP7_HUMAN;tr|H0YEN2|H0YEN2_HUMAN",2813,"H7BXH2","H7BXH2_HUMAN",null,null,"PPP6R3"]
["20.1618","18.4548","19.5859","20.7719","18.0081","19.6642",{"$nulls":3},"bicellular tight junction assembly;dendrite development;locomotory behavior;negative regulation of cell proliferation;Wnt signaling pathway","armadillo repeat domain binding;calmodulin binding;estrogen receptor binding;protein complex binding;protein phosphatase 2A binding","bicellular tight junction;cytoplasm;dendritic spine;membrane;neuronal cell body;postsynaptic density;postsynaptic membrane",{"$nulls":3},18,18,18,"42.1","42.1","42.1","86.131",0,"64.015",296970000,46,"0.0285862",1,"-0.0805314","-0.085065","sp|O43815|STRN_HUMAN","sp|O43815|STRN_HUMAN",460,"O43815","STRN_HUMAN","Striatin",null,"STRN"]
["17.6942","16.9776","16.9063","18.1766","16.8203","16.8238",{"$nulls":3},"angiogenesis;cell differentiation;innate immune response;intracellular signal transduction;negative regulation of viral genome replication;nuclear speck organization;positive regulation of cell cycle;positive regulation of cell proliferation;positive regulation of gene expression;positive regulation of neuron apoptotic process;positive regulation of viral genome replication;protein phosphorylation;regulation of mRNA splicing, via spliceosome;RNA splicing;spliceosomal complex assembly","14-3-3 protein binding;ATP binding;magnesium ion binding;protein serine/threonine kinase activity;RNA binding","cytoplasm;cytosol;nucleolus;nucleoplasm;nucleus",{"$nulls":3},14,13,13,"27.3",26,26,"77.526",0,"41.458",213820000,40,"0.0538928",1,"-0.0808404","-0.156395","sp|P78362|SRPK2_HUMAN;tr|H7C5L6|H7C5L6_HUMAN;tr|C9J2M4|C9J2M4_HUMAN;tr|C9JWF7|C9JWF7_HUMAN;tr|H7C2I2|H7C2I2_HUMAN;tr|H7C521|H7C521_HUMAN;tr|A8MPP7|A8MPP7_HUMAN;tr|A8MPY5|A8MPY5_HUMAN;sp|Q9UPE1|SRPK3_HUMAN;tr|E7ETV6|E7ETV6_HUMAN","sp|P78362|SRPK2_HUMAN",2060,"P78362","SRPK2_HUMAN","SRSF protein kinase 2",null,"SRPK2"]
["18.6618","19.6683","17.7177","19.2956","19.0471","17.9486",{"$nulls":3},"protein localization to plasma membrane;protein targeting to Golgi;regulation of defense response to virus by virus","ion channel binding","COPI-coated vesicle;cytosol",{"$nulls":3},14,14,14,"20.9","20.9","20.9","104.9",0,"26.017",286760000,28,"0.0394613",1,"-0.081164","-0.116135","sp|Q6VY07|PACS1_HUMAN;tr|B4DF77|B4DF77_HUMAN;tr|E9PNZ9|E9PNZ9_HUMAN;tr|E9PPK2|E9PPK2_HUMAN;tr|H0YF56|H0YF56_HUMAN;tr|E9PSE1|E9PSE1_HUMAN;tr|H0YE62|H0YE62_HUMAN;tr|E9PSG7|E9PSG7_HUMAN;tr|E9PNG7|E9PNG7_HUMAN;tr|H0YCU5|H0YCU5_HUMAN","sp|Q6VY07|PACS1_HUMAN;tr|B4DF77|B4DF77_HUMAN",3067,"Q6VY07","PACS1_HUMAN","Phosphofurin acidic cluster sorting protein 1","ACS-1","PACS1"]
["21.7754","19.0106","20.791","22.2479","18.874","20.705",{"$nulls":4},"catalytic activity;magnesium ion binding;thiamine pyrophosphate binding",{"$nulls":4},10,10,10,"32.4","32.4","32.4","56.732",0,"153.47",380240000,35,"0.0219323",1,"-0.0832761","-0.0657217","tr|M0R026|M0R026_HUMAN;sp|A1L0T0|ILVBL_HUMAN;tr|M0QZX5|M0QZX5_HUMAN;tr|M0R1B5|M0R1B5_HUMAN;tr|E9PJS0|E9PJS0_HUMAN;tr|E9PL44|E9PL44_HUMAN","tr|M0R026|M0R026_HUMAN;sp|A1L0T0|ILVBL_HUMAN",170,"M0R026","M0R026_HUMAN",null,null,"ILVBL"]
["27.1312","25.5721","26.491","27.0929","26.2446","26.1098",{"$nulls":3},"activation of MAPK activity;anterograde axonal transport;auditory receptor cell stereocilium organization;cell aging;cellular iron ion homeostasis;cellular response to ATP;cellular response to cadmium ion;cellular response to oxidative stress;cellular response to potassium ion;embryo implantation;glutathione metabolic process;heart contraction;hydrogen peroxide biosynthetic process;interleukin-12-mediated signaling pathway;locomotory behavior;muscle cell cellular homeostasis;myeloid cell homeostasis;negative regulation of cholesterol biosynthetic process;negative regulation of neuron apoptotic process;neurofilament cytoskeleton organization;ovarian follicle development;peripheral nervous system myelin maintenance;placenta development;platelet degranulation;positive regulation of apoptotic process;positive regulation of catalytic activity;positive regulation of cytokine production;positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;positive regulation of superoxide anion generation;reactive oxygen species metabolic process;regulation of blood pressure;regulation of GTPase activity;regulation of mitochondrial membrane potential;regulation of multicellular organism growth;regulation of organ growth;regulation of protein kinase activity;regulation of T cell differentiation in thymus;relaxation of vascular smooth muscle;removal of superoxide radicals;response to amphetamine;response to antibiotic;response to antipsychotic drug;response to axon injury;response to carbon monoxide;response to copper ion;response to drug;response to ethanol;response to heat;response to hydrogen peroxide;response to nutrient levels;response to organic substance;response to superoxide;retina homeostasis;retrograde axonal transport;sensory perception of sound;spermatogenesis;superoxide anion generation;superoxide metabolic process;thymus development;transmission of nerve impulse","chaperone binding;copper ion binding;identical protein binding;protein homodimerization activity;protein phosphatase 2B binding;Rac GTPase binding;superoxide dismutase activity;zinc ion binding","axon cytoplasm;cytoplasm;cytoplasmic vesicle;cytosol;dendrite cytoplasm;dense core granule;extracellular exosome;extracellular matrix;extracellular region;extracellular space;lysosome;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;myelin sheath;neuronal cell body;nucleoplasm;nucleus;peroxisome;protein complex","Amyotrophic lateral sclerosis (ALS);Huntington disease;Longevity regulating pathway - multiple species;Peroxisome;Prion diseases",null,null,6,6,6,63,63,63,"15.936",0,"323.31",7253900000,77,"0.0530554",1,"-0.0843124","-0.154087","sp|P00441|SODC_HUMAN;tr|H7BYH4|H7BYH4_HUMAN","sp|P00441|SODC_HUMAN;tr|H7BYH4|H7BYH4_HUMAN",827,"P00441","SODC_HUMAN","Superoxide dismutase [Cu-Zn]",null,"SOD1"]
["24.9101","23.5012","24.8009","25.1444","23.3901","24.9319",{"$nulls":3},"cell proliferation;neutrophil degranulation;signal transduction","RNA binding","extracellular region;ficolin-1-rich granule lumen",{"$nulls":3},7,7,7,"36.5","36.5","36.5","20.63",0,"118.14",1824700000,60,"0.0403298",1,"-0.0847193","-0.118588","sp|Q13442|HAP28_HUMAN;tr|F8WBW6|F8WBW6_HUMAN","sp|Q13442|HAP28_HUMAN",2359,"Q13442","HAP28_HUMAN","28 kDa heat- and acid-stable phosphoprotein",null,"PDAP1"]
["24.2266","22.5973","24.2283","24.5729","22.5198","24.2186",{"$nulls":3},"cellular response to leukemia inhibitory factor;methylation;one-carbon metabolic process;protein heterooligomerization;protein hexamerization;S-adenosylmethionine biosynthetic process","ATP binding;identical protein binding;metal ion binding;methionine adenosyltransferase activity","cytosol;methionine adenosyltransferase complex","Biosynthesis of amino acids;Cysteine and methionine metabolism;Metabolic pathways",null,null,13,13,13,"37.2","37.2","37.2","43.66",0,"117.58",2570800000,91,"0.0350072",1,"-0.0863851","-0.103489","sp|P31153|METK2_HUMAN;sp|Q00266|METK1_HUMAN","sp|P31153|METK2_HUMAN",1400,"P31153","METK2_HUMAN","S-adenosylmethionine synthase isoform type-2","doMet synthase 2","MAT2A"]
["23.5683","22.0942","23.0266","23.8301","21.9504","23.1716",{"$nulls":3},"amyloid-beta metabolic process;neutrophil degranulation;proteolysis;translational termination","identical protein binding;omega peptidase activity;RNA binding;serine-type endopeptidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nuclear membrane",{"$nulls":3},21,21,21,40,40,40,"81.224",0,"206.36",2742300000,129,"0.042767",1,"-0.0876853","-0.125451","sp|P13798|ACPH_HUMAN;tr|C9JIF9|C9JIF9_HUMAN;tr|H7C393|H7C393_HUMAN;tr|H7C1U0|H7C1U0_HUMAN;tr|C9JLK2|C9JLK2_HUMAN;tr|F8WEH5|F8WEH5_HUMAN;tr|H0YFE5|H0YFE5_HUMAN","sp|P13798|ACPH_HUMAN;tr|C9JIF9|C9JIF9_HUMAN",1090,"P13798","ACPH_HUMAN","Acylamino-acid-releasing enzyme","ARE","APEH"]
["19.8942","18.6902","19.6419","20.0747","18.4913","19.9308",{"$nulls":3},"immune response;positive regulation of cell migration;protein complex assembly;protein phosphorylation;regulation of transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;tRNA wobble uridine modification","phosphorylase kinase regulator activity;signal transducer activity","cytoplasm;cytosol;Elongator holoenzyme complex;histone acetyltransferase complex;nucleolus;transcription elongation factor complex",{"$nulls":3},20,20,20,"24.9","24.9","24.9","150.25",0,"115.16",534390000,63,"0.0495387",1,"-0.090147","-0.144359","sp|O95163|ELP1_HUMAN;tr|F5H2T0|F5H2T0_HUMAN;tr|H0YDF3|H0YDF3_HUMAN","sp|O95163|ELP1_HUMAN;tr|F5H2T0|F5H2T0_HUMAN",716,"O95163","ELP1_HUMAN","Elongator complex protein 1","LP1","ELP1"]
["15.1653","15.8547","15.5176","16.1656","15.7661","14.8769",{"$nulls":3},"endocytosis;regulation of Rho protein signal transduction","calcium ion binding;Rho guanyl-nucleotide exchange factor activity",{"$nulls":4},3,3,3,"3.8","3.8","3.8","191.6",0,"5.9682",44108000,4,"0.0737581",1,"-0.0903177","-0.210173","tr|A0A087WVF7|A0A087WVF7_HUMAN;sp|Q9NZM3|ITSN2_HUMAN;tr|E7EPJ2|E7EPJ2_HUMAN;tr|F8W719|F8W719_HUMAN","tr|A0A087WVF7|A0A087WVF7_HUMAN;sp|Q9NZM3|ITSN2_HUMAN;tr|E7EPJ2|E7EPJ2_HUMAN",4882,"A0A087WVF7","A0A087WVF7_HUMAN",null,null,"ITSN2"]
["23.672","22.7149","23.5271","23.9225","22.742","23.5234",{"$nulls":3},"threonyl-tRNA aminoacylation;translation;tRNA aminoacylation for protein translation","ATP binding;protein homodimerization activity;threonine-tRNA ligase activity;tRNA binding","actin cytoskeleton;cytoplasm;cytosol;extracellular exosome","Aminoacyl-tRNA biosynthesis",null,null,31,31,31,"46.9","46.9","46.9","83.434",0,"292.27",5719700000,208,"0.0698574",1,"-0.0912965","-0.199753","sp|P26639|SYTC_HUMAN;tr|D6R9F8|D6R9F8_HUMAN;tr|D6RCA5|D6RCA5_HUMAN;tr|D6RDJ6|D6RDJ6_HUMAN;tr|D6RBR8|D6RBR8_HUMAN;tr|B7ZLP8|B7ZLP8_HUMAN;sp|A2RTX5|SYTC2_HUMAN;tr|D6RJ97|D6RJ97_HUMAN;tr|D6RHV7|D6RHV7_HUMAN;tr|D6RCS6|D6RCS6_HUMAN","sp|P26639|SYTC_HUMAN",1311,"P26639","SYTC_HUMAN","Threonine--tRNA ligase, cytoplasmic",null,"TARS"]
["22.2051","20.1002","20.8049","22.011","20.7677","20.6095",{"$nulls":3},"purine-containing compound salvage;pyrimidine nucleoside salvage;pyrimidine nucleotide metabolic process","ATP binding;deoxycytidine kinase activity;drug binding;nucleoside kinase activity;protein homodimerization activity","cytosol;nucleus","Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,9,9,9,"38.1","38.1","38.1","30.518",0,"67.536",315280000,27,"0.0414421",1,"-0.0926253","-0.121724","sp|P27707|DCK_HUMAN;tr|D6RFG8|D6RFG8_HUMAN;tr|D6RCP9|D6RCP9_HUMAN;tr|D6RG38|D6RG38_HUMAN","sp|P27707|DCK_HUMAN;tr|D6RFG8|D6RFG8_HUMAN;tr|D6RCP9|D6RCP9_HUMAN",1327,"P27707","DCK_HUMAN","Deoxycytidine kinase","CK","DCK"]
["22.5341","22.0485","22.348","22.7374","22.1095","22.3619",{"$nulls":5},"cytosol",{"$nulls":3},37,37,31,"40.2","40.2","34.1","101.2",0,"215.22",3125400000,204,"0.149688",1,"-0.0927219","-0.401682","tr|A0A0B4J1W3|A0A0B4J1W3_HUMAN;sp|Q9BXJ9|NAA15_HUMAN","tr|A0A0B4J1W3|A0A0B4J1W3_HUMAN;sp|Q9BXJ9|NAA15_HUMAN",4293,"A0A0B4J1W3","A0A0B4J1W3_HUMAN",null,null,"NAA15"]
["16.913","15.3688","17.7132","17.365","15.2335","17.6754",{"$nulls":5},"cytosol;Golgi apparatus;intracellular membrane-bounded organelle",{"$nulls":3},16,16,16,"9.8","9.8","9.8","246.6",0,"35.551",171330000,25,"0.0303741",1,"-0.0929896","-0.0902184","tr|H0Y6I0|H0Y6I0_HUMAN;sp|Q13439|GOGA4_HUMAN;tr|A0A087WTW2|A0A087WTW2_HUMAN;tr|E7EVX2|E7EVX2_HUMAN;tr|C9JHJ5|C9JHJ5_HUMAN","tr|H0Y6I0|H0Y6I0_HUMAN;sp|Q13439|GOGA4_HUMAN",2358,"H0Y6I0","H0Y6I0_HUMAN",null,null,"GOLGA4"]
["20.7491","19.056","19.753","20.2897","19.2418","20.3094",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;tRNA export from nucleus;viral process;viral transcription","protein dimerization activity","endoplasmic reticulum membrane;host cell;integral component of membrane;membrane;nuclear envelope;nuclear membrane;nuclear pore","RNA transport",null,null,33,33,33,"24.9","24.9","24.9","205.11",0,"114.27",823320000,85,"0.0537163",1,"-0.0942853","-0.155909","sp|Q8TEM1|PO210_HUMAN","sp|Q8TEM1|PO210_HUMAN",3578,"Q8TEM1","PO210_HUMAN","Nuclear pore membrane glycoprotein 210","uclear pore protein gp210","NUP210"]
["20.4026","17.2362","19.845","20.1835","17.3567","20.235",{"$nulls":3},"actin cytoskeleton organization;activation of protein kinase activity;apoptotic process;cell cycle;cell growth;cell migration;cell proliferation;cellular response to organic cyclic compound;cytoskeleton organization;dendritic spine development;movement of cell or subcellular component;negative regulation of endothelial cell apoptotic process;positive regulation of angiogenesis;regulation of apoptotic process;regulation of MAPK cascade;regulation of mitotic cell cycle;Rho protein signal transduction;signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;cadherin binding involved in cell-cell adhesion;protein kinase activity;protein serine/threonine kinase activity;Rac GTPase binding","cell-cell adherens junction;focal adhesion;Golgi apparatus","Axon guidance;ErbB signaling pathway;Focal adhesion;Human immunodeficiency virus 1 infection;MicroRNAs in cancer;Ras signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway",null,null,7,7,7,"19.8","19.8","19.8","64.071",0,"29.087",163190000,22,"0.0238399",1,"-0.0971457","-0.0712941","sp|O96013|PAK4_HUMAN;tr|M0R2X4|M0R2X4_HUMAN;tr|M0R3G6|M0R3G6_HUMAN;tr|M0R0L9|M0R0L9_HUMAN;tr|M0R1R1|M0R1R1_HUMAN","sp|O96013|PAK4_HUMAN",815,"O96013","PAK4_HUMAN","Serine/threonine-protein kinase PAK 4",null,"PAK4"]
["19.2988","20.3135","21.1398","19.324","20.3205","21.4004",{"$nulls":3},"covalent chromatin modification;nucleosome assembly;regulation of transcription from RNA polymerase II promoter;spermatogenesis;transcription, DNA-templated","chromatin binding;lysine-acetylated histone binding","cytoplasm;nucleoplasm",{"$nulls":3},25,25,20,"39.5","39.5","35.1","88.06",0,"185.47",2133600000,153,"0.0414239",1,"-0.0975602","-0.121673","sp|P25440|BRD2_HUMAN;tr|A0A0G2JK44|A0A0G2JK44_HUMAN;tr|H0Y6K2|H0Y6K2_HUMAN;tr|U3KQA6|U3KQA6_HUMAN;tr|A0A0G2JHL0|A0A0G2JHL0_HUMAN;tr|A0A0G2JHN8|A0A0G2JHN8_HUMAN;tr|E9PIQ3|E9PIQ3_HUMAN;tr|H0Y799|H0Y799_HUMAN;tr|E9PKQ9|E9PKQ9_HUMAN;tr|H0YDJ7|H0YDJ7_HUMAN;tr|U3KPW0|U3KPW0_HUMAN","sp|P25440|BRD2_HUMAN;tr|A0A0G2JK44|A0A0G2JK44_HUMAN;tr|H0Y6K2|H0Y6K2_HUMAN;tr|U3KQA6|U3KQA6_HUMAN;tr|A0A0G2JHL0|A0A0G2JHL0_HUMAN",1289,"P25440","BRD2_HUMAN","Bromodomain-containing protein 2",null,"BRD2"]
["22.0761","22.5235","22.482","22.3974","22.4172","22.5638",{"$nulls":3},"apoptotic process;positive regulation of apoptotic process;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding","cytoplasm;cytosol;nucleoplasm;nucleus","Ubiquitin mediated proteolysis",null,null,9,9,9,"27.4","27.4","27.4","38.21",0,"33.755",755130000,25,"0.259083",1,"-0.0989456","-0.650741","sp|Q9H832|UBE2Z_HUMAN;tr|I3L286|I3L286_HUMAN;tr|I3L4C5|I3L4C5_HUMAN;tr|H0Y9X8|H0Y9X8_HUMAN;tr|D6RB11|D6RB11_HUMAN;tr|I3L3V3|I3L3V3_HUMAN","sp|Q9H832|UBE2Z_HUMAN",4515,"Q9H832","UBE2Z_HUMAN","Ubiquitin-conjugating enzyme E2 Z",null,"UBE2Z"]
["23.8799","22.2569","23.1642","23.9466","22.5583","23.0981",{"$nulls":3},"binding of sperm to zona pellucida;hematopoietic stem cell homeostasis;positive regulation of gene expression","RNA binding","cytoplasm;PcG protein complex",{"$nulls":3},24,24,24,"37.5","37.5","37.5","114.53",0,"274.54",2841600000,184,"0.0561232",1,"-0.100686","-0.162524","sp|Q14157|UBP2L_HUMAN;tr|F8W726|F8W726_HUMAN;tr|Q5VU77|Q5VU77_HUMAN;tr|Q5VU78|Q5VU78_HUMAN;tr|Q5VU81|Q5VU81_HUMAN;tr|Q5VU80|Q5VU80_HUMAN;tr|Q5VU79|Q5VU79_HUMAN;tr|H0Y5H6|H0Y5H6_HUMAN;tr|H7C2T8|H7C2T8_HUMAN","sp|Q14157|UBP2L_HUMAN;tr|F8W726|F8W726_HUMAN",2443,"Q14157","UBP2L_HUMAN","Ubiquitin-associated protein 2-like",null,"UBAP2L"]
["18.7636","16.9153","18.6661","19.3256","16.4351","18.8923",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;cargo loading into COPII-coated vesicle;COPII vesicle coating;ER to Golgi vesicle-mediated transport;intracellular protein transport;positive regulation of cholesterol homeostasis;positive regulation of protein secretion;regulation of low-density lipoprotein particle receptor biosynthetic process","zinc ion binding","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane","Protein processing in endoplasmic reticulum",null,null,10,9,9,"11.8","11.1","11.1","119.75",0,"27.961",126540000,14,"0.0320034",1,"-0.102676","-0.0948989","sp|O95486|SC24A_HUMAN;tr|H0Y9J6|H0Y9J6_HUMAN","sp|O95486|SC24A_HUMAN",763,"O95486","SC24A_HUMAN","Protein transport protein Sec24A {ECO:0000305}",null,"SEC24A"]
["22.499","22.5957","22.3514","23.123","22.3658","22.2706",{"$nulls":3},"positive regulation of protein targeting to mitochondrion;protein sumoylation;protein ubiquitination","ATP-dependent protein binding;enzyme activator activity;protein C-terminus binding;protein heterodimerization activity;small protein activating enzyme binding;ubiquitin activating enzyme activity","cytoplasm;nucleoplasm;nucleus;SUMO activating enzyme complex","Ubiquitin mediated proteolysis",null,null,15,15,15,"53.5","53.5","53.5","38.449",0,"182.64",1255700000,66,"0.138418",1,"-0.104425","-0.374443","sp|Q9UBE0|SAE1_HUMAN;tr|M0QZS6|M0QZS6_HUMAN;tr|B3KNJ4|B3KNJ4_HUMAN;tr|M0QX65|M0QX65_HUMAN;tr|M0R054|M0R054_HUMAN;tr|M0QYM8|M0QYM8_HUMAN;tr|M0R286|M0R286_HUMAN;tr|M0R375|M0R375_HUMAN;tr|M0QYP2|M0QYP2_HUMAN","sp|Q9UBE0|SAE1_HUMAN;tr|M0QZS6|M0QZS6_HUMAN;tr|B3KNJ4|B3KNJ4_HUMAN;tr|M0QX65|M0QX65_HUMAN",4953,"Q9UBE0","SAE1_HUMAN","SUMO-activating enzyme subunit 1",null,"SAE1"]
["16.9395","16.5864","15.4488","16.5909","16.5868","16.1172",{"$nulls":3},"nucleobase-containing compound metabolic process","RNA binding",{"$nulls":4},7,7,7,"10.6","10.6","10.6","111.77",0,"12.359",390140000,11,"0.078961",1,"-0.106707","-0.223969","sp|Q8N5C6|SRBD1_HUMAN","sp|Q8N5C6|SRBD1_HUMAN",3410,"Q8N5C6","SRBD1_HUMAN","S1 RNA-binding domain-containing protein 1",null,"SRBD1"]
["22.8013","21.637","22.5569","22.8702","21.7515","22.6998",{"$nulls":3},"DNA damage response, detection of DNA damage;DNA repair;DNA replication;error-free translesion synthesis;error-prone translesion synthesis;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of DNA-directed DNA polymerase activity;regulation of signal transduction by p53 class mediator;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","ATP binding;DNA binding;enzyme binding","Ctf18 RFC-like complex;DNA replication factor C complex;nucleoplasm;nucleus","DNA replication;Mismatch repair;Nucleotide excision repair",null,null,19,19,19,"61.3","61.3","61.3","39.157",0,"287.69",2943100000,167,"0.0770821",1,"-0.108788","-0.219","sp|P35250|RFC2_HUMAN;tr|A0A087WVY3|A0A087WVY3_HUMAN;tr|H7C5P4|H7C5P4_HUMAN;tr|H7C596|H7C596_HUMAN;tr|H7C5P1|H7C5P1_HUMAN;tr|H7C5Q7|H7C5Q7_HUMAN;tr|F8WC37|F8WC37_HUMAN;tr|H7C5A0|H7C5A0_HUMAN;tr|H7C5G4|H7C5G4_HUMAN;tr|H7C5S7|H7C5S7_HUMAN","sp|P35250|RFC2_HUMAN;tr|A0A087WVY3|A0A087WVY3_HUMAN;tr|H7C5P4|H7C5P4_HUMAN",1455,"P35250","RFC2_HUMAN","Replication factor C subunit 2",null,"RFC2"]
["21.7389","20.4702","20.9392","21.9027","20.4843","21.0956",{"$nulls":3},"cellular response to oxidative stress;positive regulation by virus of viral protein levels in host cell;positive regulation of long-term synaptic potentiation;positive regulation of viral genome replication","double-stranded RNA binding;protein phosphatase 1 binding;RNA binding","cell body;cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;dendrite;endoplasmic reticulum;extracellular exosome;membrane;microtubule associated complex;neuronal cell body;plasma membrane;rough endoplasmic reticulum",{"$nulls":3},14,14,14,"35.4","35.4","35.4","63.182",0,"94.025",909070000,81,"0.0705232",1,"-0.111461","-0.201536","sp|O95793|STAU1_HUMAN;tr|Q5JW30|Q5JW30_HUMAN;tr|A0A087X1A5|A0A087X1A5_HUMAN;tr|Q5JW28|Q5JW28_HUMAN;tr|F6UDC6|F6UDC6_HUMAN","sp|O95793|STAU1_HUMAN;tr|Q5JW30|Q5JW30_HUMAN;tr|A0A087X1A5|A0A087X1A5_HUMAN",791,"O95793","STAU1_HUMAN","Double-stranded RNA-binding protein Staufen homolog 1",null,"STAU1"]
["18.9833","16.8147","18.2684","19.4975","16.8202","18.0853",{"$nulls":3},"rRNA processing;tRNA 5'-leader removal","ribonuclease P activity","nucleolar ribonuclease P complex;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes;RNA transport",null,null,5,5,5,"19.3","19.3","19.3","41.833",0,"13.784",91563000,9,"0.0379758",1,"-0.11221","-0.111929","sp|O75818|RPP40_HUMAN;tr|X6RLL4|X6RLL4_HUMAN;tr|A0A087X1N3|A0A087X1N3_HUMAN;tr|F8WC38|F8WC38_HUMAN","sp|O75818|RPP40_HUMAN;tr|X6RLL4|X6RLL4_HUMAN;tr|A0A087X1N3|A0A087X1N3_HUMAN",635,"O75818","RPP40_HUMAN","Ribonuclease P protein subunit p40","NaseP protein p40","RPP40"]
["22.8122","21.1088","22.3074","22.8778","21.1927","22.4957",{"$nulls":3},"cellular response to amino acid starvation;cellular response to leucine starvation;positive regulation of kinase activity;positive regulation of transcription from RNA polymerase II promoter in response to stress;regulation of translation","cadherin binding;protein kinase binding;protein kinase regulator activity;ribosome binding;RNA binding;translation factor activity, RNA binding","cytoplasm;cytosol;membrane;polysome;ribosome",{"$nulls":3},113,113,113,"54.2","54.2","54.2","292.75",0,"323.31",8898700000,664,"0.0540427",1,"-0.112567","-0.156807","sp|Q92616|GCN1L_HUMAN","sp|Q92616|GCN1L_HUMAN",3693,"Q92616","GCN1_HUMAN","eIF-2-alpha kinase activator GCN1 {ECO:0000250|UniProtKB:E9PVA8}",null,"GCN1"]
["19.1402","16.67","18.5006","18.2864","17.6419","18.7264",{"$nulls":4},"microtubule binding","cytoplasm;microtubule;microtubule cytoskeleton",{"$nulls":3},9,9,9,"14.4","14.4","14.4","95.196",0,"34.148",173300000,22,"0.0488761",1,"-0.114645","-0.142519","sp|Q32P44|EMAL3_HUMAN;tr|B7WPE2|B7WPE2_HUMAN;tr|H0Y3M3|H0Y3M3_HUMAN;tr|G3V1D0|G3V1D0_HUMAN;tr|G3V195|G3V195_HUMAN;tr|H7C355|H7C355_HUMAN","sp|Q32P44|EMAL3_HUMAN;tr|B7WPE2|B7WPE2_HUMAN;tr|H0Y3M3|H0Y3M3_HUMAN;tr|G3V1D0|G3V1D0_HUMAN;tr|G3V195|G3V195_HUMAN",2733,"Q32P44","EMAL3_HUMAN","Echinoderm microtubule-associated protein-like 3","MAP-3","EML3"]
["17.6471","16.3633","14.8298","17.9516","16.3144","14.9218",{"$nulls":3},"regulation of Rho protein signal transduction","nucleic acid binding;Rho guanyl-nucleotide exchange factor activity","cytosol;plasma membrane",{"$nulls":3},7,7,7,"8.4","8.4","8.4","116.32",0,"12.48",67578000,6,"0.0327076",1,"-0.115886","-0.0969171","tr|A0A087WZG4|A0A087WZG4_HUMAN;tr|M0R150|M0R150_HUMAN;sp|Q6ZSZ5|ARHGI_HUMAN;tr|M0QZS0|M0QZS0_HUMAN","tr|A0A087WZG4|A0A087WZG4_HUMAN;tr|M0R150|M0R150_HUMAN;sp|Q6ZSZ5|ARHGI_HUMAN;tr|M0QZS0|M0QZS0_HUMAN",3087,"A0A087WZG4","A0A087WZG4_HUMAN"]
[1,"19.3196","16.8792",1,"19.5088","17.0459",{"$nulls":3},"positive regulation of transcription from RNA polymerase II promoter;regulation of mitotic cell cycle;transcription initiation from RNA polymerase II promoter","ATP binding;cyclin-dependent protein serine/threonine kinase activity;protein kinase activity;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity","mediator complex;nucleolus;nucleoplasm;nucleus;protein complex",{"$nulls":3},5,5,5,"10.8","10.8","10.8","53.283",0,"9.9566",96228000,7,"0.004759",1,"-0.118641","-0.0145316","sp|P49336|CDK8_HUMAN;tr|A0A0D9SFZ2|A0A0D9SFZ2_HUMAN;tr|Q5JQZ9|Q5JQZ9_HUMAN;sp|Q9BWU1|CDK19_HUMAN;tr|A0A0D9SEP3|A0A0D9SEP3_HUMAN;tr|F5H6D4|F5H6D4_HUMAN;tr|F6QTA4|F6QTA4_HUMAN","sp|P49336|CDK8_HUMAN;tr|A0A0D9SFZ2|A0A0D9SFZ2_HUMAN;tr|Q5JQZ9|Q5JQZ9_HUMAN;sp|Q9BWU1|CDK19_HUMAN",1651,"P49336","CDK8_HUMAN","Cyclin-dependent kinase 8",null,"CDK8"]
["22.2757","20.2603","21.5247","22.4419","20.2096","21.7669",{"$nulls":3},"activation of protein kinase activity;cellular hypotonic response;intracellular signal transduction;maintenance of lens transparency;negative regulation of creatine transmembrane transporter activity;negative regulation of pancreatic juice secretion;negative regulation of potassium ion transmembrane transport;negative regulation of potassium ion transmembrane transporter activity;negative regulation of protein phosphorylation;negative regulation of rubidium ion transmembrane transporter activity;negative regulation of rubidium ion transport;negative regulation of sodium ion transmembrane transporter activity;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of ion transmembrane transporter activity;positive regulation of potassium ion transport;protein autophosphorylation;protein phosphorylation;regulation of apoptotic process;regulation of blood pressure;regulation of inflammatory response;regulation of ion homeostasis;regulation of mitotic cell cycle;response to stress;signal transduction by protein phosphorylation;signal transduction by trans-phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;kinase activity;protein kinase binding;protein serine/threonine kinase activity;signal transducer, downstream of receptor, with serine/threonine kinase activity","apical plasma membrane;basolateral plasma membrane;cytoplasm;cytoskeleton;cytosol;extrinsic component of membrane;intracellular membrane-bounded organelle;nucleoplasm;nucleus",{"$nulls":3},15,15,12,"41.1","41.1","33.6","59.473",0,"100.68",893420000,82,"0.0460861",1,"-0.119215","-0.134748","sp|Q9UEW8|STK39_HUMAN;tr|F8WBK9|F8WBK9_HUMAN","sp|Q9UEW8|STK39_HUMAN",4993,"Q9UEW8","STK39_HUMAN","STE20/SPS1-related proline-alanine-rich protein kinase","te-20-related kinase","STK39"]
["25.9067","25.7423","26.1889","25.9603","25.6624","26.5749",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleus;ribosome","Ribosome",null,null,6,6,6,"44.9","44.9","44.9","15.798",0,"87.736",5178100000,143,"0.149599",1,"-0.119888","-0.401468","sp|P61353|RL27_HUMAN;tr|K7ELC7|K7ELC7_HUMAN;tr|K7EQQ9|K7EQQ9_HUMAN;tr|K7ERY7|K7ERY7_HUMAN","sp|P61353|RL27_HUMAN;tr|K7ELC7|K7ELC7_HUMAN;tr|K7EQQ9|K7EQQ9_HUMAN",1930,"P61353","RL27_HUMAN","60S ribosomal protein L27",null,"RPL27"]
["25.5668","24.8167","24.3422","26.0548","24.7459","24.2872",{"$nulls":3},"DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;establishment of skin barrier;intrinsic apoptotic signaling pathway in response to DNA damage;keratinization;keratinocyte development;membrane organization;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of keratinocyte proliferation;negative regulation of protein kinase activity;positive regulation of cell growth;positive regulation of epidermal cell differentiation;positive regulation of protein export from nucleus;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;regulation of cyclin-dependent protein serine/threonine kinase activity;regulation of epidermal cell division;release of cytochrome c from mitochondria;signal transduction","cadherin binding;identical protein binding;phosphoprotein binding;protein domain specific binding;protein kinase binding;protein kinase C inhibitor activity","cytoplasmic vesicle membrane;cytosol;extracellular exosome;extracellular space;mitochondrion;nucleus","Aldosterone-regulated sodium reabsorption;Cell cycle;p53 signaling pathway",null,null,16,13,13,"70.6","63.3","63.3","27.774",0,"261.56",5738800000,110,"0.0659008",1,"-0.12073","-0.189116","sp|P31947|1433S_HUMAN","sp|P31947|1433S_HUMAN",1416,"P31947","1433S_HUMAN","14-3-3 protein sigma",null,"SFN"]
["24.6633","21.574","23.2634","24.1826","22.0361","23.645",{"$nulls":3},"cytoplasmic translational initiation;translational initiation","translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m",{"$nulls":3},15,15,15,"64.7","64.7","64.7","42.502",0,"323.31",2045500000,123,"0.0372357",1,"-0.120988","-0.109829","sp|Q7L2H7|EIF3M_HUMAN;tr|H0YCQ8|H0YCQ8_HUMAN;tr|J3KNJ2|J3KNJ2_HUMAN;tr|E9PRY0|E9PRY0_HUMAN;tr|E9PN86|E9PN86_HUMAN;tr|E7ESM3|E7ESM3_HUMAN;tr|E9PRI2|E9PRI2_HUMAN","sp|Q7L2H7|EIF3M_HUMAN;tr|H0YCQ8|H0YCQ8_HUMAN;tr|J3KNJ2|J3KNJ2_HUMAN",3119,"Q7L2H7","EIF3M_HUMAN","Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012}","IF3m {ECO:0000255|HAMAP-Rule:MF_03012}","EIF3M"]
["20.8683","17.8556","19.5395","19.9498","18.9393","19.7385",{"$nulls":3},"COPII vesicle coating","Rab guanyl-nucleotide exchange factor activity","cytosol;endoplasmic reticulum;Golgi apparatus;Golgi membrane;TRAPP complex",{"$nulls":3},3,3,3,"16.1","16.1","16.1","20.274",0,"9.7937",73642000,10,"0.0448583",1,"-0.121391","-0.131316","sp|O43617|TPPC3_HUMAN;tr|A0A087WWM0|A0A087WWM0_HUMAN;tr|A6NKE1|A6NKE1_HUMAN;tr|A0A087WYS5|A0A087WYS5_HUMAN","sp|O43617|TPPC3_HUMAN;tr|A0A087WWM0|A0A087WWM0_HUMAN;tr|A6NKE1|A6NKE1_HUMAN",434,"O43617","TPPC3_HUMAN","Trafficking protein particle complex subunit 3",null,"TRAPPC3"]
["19.3411","17.1264","16.4985","19.2484","17.435","16.6558",{"$nulls":3},"blood coagulation;histone H4 deacetylation;negative regulation of transcription, DNA-templated;transcription, DNA-templated;viral process","histone deacetylase activity;transcription corepressor activity;transcription factor binding;transcription regulatory region DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","DNA repair complex;nucleoplasm;nucleus;transcription factor complex;transcriptional repressor complex","Huntington disease",null,null,6,6,6,"18.3","18.3","18.3","53.027",0,"39.483",106630000,17,"0.0365092",1,"-0.12443","-0.107765","sp|Q9UKL0|RCOR1_HUMAN;tr|J3KN32|J3KN32_HUMAN;tr|E9PQE5|E9PQE5_HUMAN;tr|B4DV59|B4DV59_HUMAN;sp|Q9P2K3|RCOR3_HUMAN","sp|Q9UKL0|RCOR1_HUMAN;tr|J3KN32|J3KN32_HUMAN",5093,"Q9UKL0","RCOR1_HUMAN","REST corepressor 1",null,"RCOR1"]
["23.9879","22.1564","22.7071","24.1259","22.3444","22.7621",{"$nulls":3},"IRES-dependent viral translational initiation;protein deubiquitination;translational initiation","thiol-dependent ubiquitin-specific protease activity;translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;membrane","RNA transport",null,null,11,11,11,"46.5","46.5","46.5","37.563",0,"94.99",1173000000,77,"0.057485",1,"-0.127015","-0.166254","sp|O00303|EIF3F_HUMAN;tr|H0YDT6|H0YDT6_HUMAN;tr|A0A0D9SEZ9|A0A0D9SEZ9_HUMAN;tr|E9PQV8|E9PQV8_HUMAN","sp|O00303|EIF3F_HUMAN",225,"O00303","EIF3F_HUMAN","Eukaryotic translation initiation factor 3 subunit F {ECO:0000255|HAMAP-Rule:MF_03005}","IF3f {ECO:0000255|HAMAP-Rule:MF_03005}","EIF3F"]
["19.3748","15.6802","19.4893","19.8709","15.8944","19.1655",{"$nulls":3},"histone mRNA catabolic process;mRNA polyadenylation;transcription, DNA-templated","ATP binding;identical protein binding;magnesium ion binding;manganese ion binding;polynucleotide adenylyltransferase activity;protein homodimerization activity;RNA binding;UTP binding","intracellular membrane-bounded organelle;mitochondrion",{"$nulls":3},15,15,15,"29.2","29.2","29.2","66.171",0,"108.6",758560000,96,"0.0246248",1,"-0.128832","-0.0735805","sp|Q9NVV4|PAPD1_HUMAN;tr|Q5T851|Q5T851_HUMAN;tr|Q5T852|Q5T852_HUMAN","sp|Q9NVV4|PAPD1_HUMAN",4778,"Q9NVV4","PAPD1_HUMAN","Poly(A) RNA polymerase, mitochondrial","AP","MTPAP"]
["27.908","26.5739","27.4517","27.9797","26.7465","27.5977",{"$nulls":3},"aging;cellular response to brain-derived neurotrophic factor stimulus;glial cell proliferation;hematopoietic progenitor cell differentiation;neutrophil degranulation;peptidyl-diphthamide biosynthetic process from peptidyl-histidine;positive regulation of cytoplasmic translation;positive regulation of translation;protein methylation;response to drug;response to endoplasmic reticulum stress;response to estradiol;response to ethanol;response to folic acid;response to hydrogen peroxide;response to ischemia;skeletal muscle cell differentiation;skeletal muscle contraction;translational elongation","5S rRNA binding;actin filament binding;cadherin binding;GTP binding;GTPase activity;p53 binding;protein kinase binding;ribosome binding;RNA binding;translation elongation factor activity","aggresome;cytoplasm;cytosol;extracellular exosome;extracellular matrix;extracellular region;ficolin-1-rich granule lumen;intracellular ribonucleoprotein complex;membrane;membrane raft;nucleus;plasma membrane;polysomal ribosome;secretory granule lumen","AMPK signaling pathway;Oxytocin signaling pathway",null,null,55,55,54,"65.2","65.2",64,"95.337",0,"323.31",80373000000,1281,"0.0863103",1,"-0.130119","-0.243266","sp|P13639|EF2_HUMAN;tr|M0R0I6|M0R0I6_HUMAN","sp|P13639|EF2_HUMAN",1082,"P13639","EF2_HUMAN","Elongation factor 2","F-2","EEF2"]
["19.0006","18.8559","20.6598","19.7829","18.5826","20.5438",{"$nulls":3},"3'-phosphoadenosine 5'-phosphosulfate metabolic process;chondrocyte development;chondroitin sulfate metabolic process;embryonic digit morphogenesis;endochondral ossification;inositol biosynthetic process;phosphatidylinositol phosphorylation;post-embryonic development","3'(2'),5'-bisphosphate nucleotidase activity;3'-nucleotidase activity;inositol monophosphate 1-phosphatase activity;inositol monophosphate 3-phosphatase activity;inositol monophosphate 4-phosphatase activity;metal ion binding","cytosol;Golgi apparatus;Golgi lumen;integral component of membrane;membrane;nuclear body;nucleus","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Sulfur metabolism",null,null,5,5,5,"16.4","16.4","16.4","38.681",0,"80.238",127560000,8,"0.0556134",1,"-0.130974","-0.161125","sp|Q9NX62|IMPA3_HUMAN;tr|H0YBS3|H0YBS3_HUMAN;tr|H0YB38|H0YB38_HUMAN","sp|Q9NX62|IMPA3_HUMAN",4817,"Q9NX62","IMPA3_HUMAN","Inositol monophosphatase 3","MP 3;MPase 3","IMPAD1"]
["23.4252","22.9403","23.0017","23.6253","22.9765","23.1603",{"$nulls":3},"cell cycle;cell division","RNA binding","cytoplasm;microtubule organizing center;midbody",{"$nulls":3},16,16,16,"50.7","50.7","50.7","25.835",0,"120.13",2647200000,168,"0.206994",1,"-0.131665","-0.535204","sp|Q96CT7|CC124_HUMAN;tr|M0R2F5|M0R2F5_HUMAN","sp|Q96CT7|CC124_HUMAN;tr|M0R2F5|M0R2F5_HUMAN",3829,"Q96CT7","CC124_HUMAN","Coiled-coil domain-containing protein 124",null,"CCDC124"]
[1,"16.3219","16.6379","16.5105",1,"16.8495",{"$nulls":3},"metabolic process","catalytic activity","integral component of membrane",{"$nulls":3},1,1,1,"7.3","7.3","7.3","20.969","0.001364","3.212",6326600,2,"0.00595494",1,"-0.133392","-0.0181588","tr|D6R9J9|D6R9J9_HUMAN;tr|E7EM50|E7EM50_HUMAN;tr|D6RFE8|D6RFE8_HUMAN;tr|E7EWV1|E7EWV1_HUMAN;sp|Q5H8A4|PIGG_HUMAN","tr|D6R9J9|D6R9J9_HUMAN;tr|E7EM50|E7EM50_HUMAN;tr|D6RFE8|D6RFE8_HUMAN;tr|E7EWV1|E7EWV1_HUMAN;sp|Q5H8A4|PIGG_HUMAN",2811,"D6R9J9","D6R9J9_HUMAN",null,null,"PIGG"]
["26.1442","25.3582","26.1065","26.3409","25.4719","26.2037",{"$nulls":3},"chronic inflammatory response to antigenic stimulus;circadian sleep/wake cycle;homocysteine biosynthetic process;methylation;one-carbon metabolic process;response to hypoxia;response to nutrient;S-adenosylhomocysteine catabolic process;S-adenosylmethionine cycle;sulfur amino acid metabolic process","adenosylhomocysteinase activity;adenyl nucleotide binding;identical protein binding;NAD binding","cytosol;extracellular exosome;melanosome;neuron projection;nucleus","Cysteine and methionine metabolism;Metabolic pathways",null,null,20,20,20,"43.3","43.3","43.3","47.716",0,"267.2",14646000000,254,"0.134722",1,"-0.135879","-0.36543","sp|P23526|SAHH_HUMAN","sp|P23526|SAHH_HUMAN",1269,"P23526","SAHH_HUMAN","Adenosylhomocysteinase","doHcyase","AHCY"]
["20.67","21.1889","21.1245","21.3791","20.8537","21.1642",{"$nulls":3},"COPII-coated vesicle budding;intracellular protein transport","zinc ion binding","COPII vesicle coat;cytosol;endomembrane system;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane;perinuclear region of cytoplasm","Protein processing in endoplasmic reticulum",null,null,17,17,15,"28.9","28.9","27.6","86.478",0,"97.287",784850000,49,"0.243621",1,"-0.13784","-0.616934","sp|Q15437|SC23B_HUMAN;tr|Q5QPE2|Q5QPE2_HUMAN;tr|Q5QPE1|Q5QPE1_HUMAN","sp|Q15437|SC23B_HUMAN",2605,"Q15437","SC23B_HUMAN","Protein transport protein Sec23B {ECO:0000305}","Sec23B {ECO:0000303|PubMed:8898360}","SEC23B"]
["22.3981","21.6376","21.9541","23.1463","21.2261","22.0391",{"$nulls":3},"protein deneddylation",null,"COP9 signalosome;nucleoplasm",{"$nulls":3},7,7,7,"30.1","30.1","30.1","36.064",0,"39.43",445610000,28,"0.0830495",1,"-0.14051","-0.234731","tr|E7EM64|E7EM64_HUMAN;sp|Q7L5N1|CSN6_HUMAN;tr|H7C3T0|H7C3T0_HUMAN","tr|E7EM64|E7EM64_HUMAN;sp|Q7L5N1|CSN6_HUMAN",3127,"E7EM64","E7EM64_HUMAN",null,null,"COPS6"]
["17.457","15.1727","17.4523","17.7905","15.5452","17.1716",{"$nulls":3},"negative regulation of cell migration;positive regulation of anion channel activity;positive regulation of protein targeting to membrane","ion channel binding","plasma membrane",{"$nulls":3},4,4,4,"6.8","6.8","6.8","102.12",0,"14.183",53712000,3,"0.0479457",1,"-0.141802","-0.139932","sp|Q9Y4C2|TCAF1_HUMAN","sp|Q9Y4C2|TCAF1_HUMAN",5321,"Q9Y4C2","TCAF1_HUMAN","TRPM8 channel-associated factor 1 {ECO:0000303|PubMed:25559186}",null,"TCAF1"]
["16.1741","14.9742","15.8145","16.2002","14.9006","16.2898",{"$nulls":3},"cellular response to fatty acid;cellular response to glucose stimulus;glucose metabolic process;hypoxia-inducible factor-1alpha signaling pathway;peptidyl-serine phosphorylation;peroxisome proliferator activated receptor signaling pathway;regulation of acetyl-CoA biosynthetic process from pyruvate;regulation of glucose metabolic process;regulation of reactive oxygen species metabolic process","ATP binding;protein kinase activity;protein serine/threonine kinase activity;pyruvate dehydrogenase (acetyl-transferring) kinase activity","mitochondrial matrix;mitochondrion;nucleolus",{"$nulls":3},2,2,2,"6.2","6.2","6.2","46.938","0.0010128","3.7485",13251000,7,"0.0885353",1,"-0.142621","-0.249065","sp|Q15120|PDK3_HUMAN","sp|Q15120|PDK3_HUMAN",2561,"Q15120","PDK3_HUMAN","[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial",null,"PDK3"]
["21.8419","20.2047","20.3419","22.5995","20.3626","19.8619",{"$nulls":3},"enzyme linked receptor protein signaling pathway;tissue development",null,"endoplasmic reticulum",{"$nulls":3},7,6,0,"33.8","30.4",0,"29.224",0,"52.657",344590000,29,"0.0502705",1,"-0.145158","-0.146389","tr|F8W031|F8W031_HUMAN;tr|F8VXJ7|F8VXJ7_HUMAN;tr|F8W1K5|F8W1K5_HUMAN;tr|F8VP03|F8VP03_HUMAN;tr|H0YIH9|H0YIH9_HUMAN;tr|F8W1U5|F8W1U5_HUMAN","tr|F8W031|F8W031_HUMAN;tr|F8VXJ7|F8VXJ7_HUMAN;tr|F8W1K5|F8W1K5_HUMAN",5540,"F8W031","F8W031_HUMAN"]
["21.0947","18.9524","20.0523","20.9282","19.3158","20.3021",{"$nulls":3},"miRNA metabolic process;positive regulation of RNA interference;pre-miRNA export from nucleus;protein export from nucleus;regulation of protein export from nucleus","mRNA binding;nuclear export signal receptor activity;pre-miRNA binding;pre-miRNA transporter activity;Ran GTPase binding;RNA binding;tRNA binding","cytoplasm;cytosol;micro-ribonucleoprotein complex;nuclear RNA export factor complex;nucleoplasm;nucleus;RNA nuclear export complex","RNA transport",null,null,23,23,23,"29.3","29.3","29.3","136.31",0,"305.03",702610000,78,"0.0668722",1,"-0.148869","-0.191734","sp|Q9HAV4|XPO5_HUMAN;tr|H0Y3W3|H0Y3W3_HUMAN;tr|E2QRM3|E2QRM3_HUMAN;tr|H0Y9I3|H0Y9I3_HUMAN;tr|H0YA57|H0YA57_HUMAN","sp|Q9HAV4|XPO5_HUMAN",4562,"Q9HAV4","XPO5_HUMAN","Exportin-5","xp5","XPO5"]
["22.9044","22.7463","23.1125","23.2644","22.4107","23.5388",{"$nulls":3},"cellular response to insulin stimulus;liver regeneration;mRNA 3'-end processing;mRNA export from nucleus;mRNA processing;mRNA splice site selection;mRNA splicing, via spliceosome;positive regulation of RNA splicing;regulation of cell cycle;RNA export from nucleus;termination of RNA polymerase II transcription","protein kinase B binding;RNA binding","cytosol;nuclear speck;nucleolus;nucleoplasm;nucleus","Herpes simplex virus 1 infection;Spliceosome",null,null,6,5,5,25,"21.7","21.7","31.263",0,"21.79",601890000,32,"0.158304",1,"-0.150256","-0.422269","sp|Q13243|SRSF5_HUMAN;tr|B4DJK0|B4DJK0_HUMAN;tr|B4DUA4|B4DUA4_HUMAN;tr|G3V5K8|G3V5K8_HUMAN","sp|Q13243|SRSF5_HUMAN;tr|B4DJK0|B4DJK0_HUMAN;tr|B4DUA4|B4DUA4_HUMAN",2329,"Q13243","SRSF5_HUMAN","Serine/arginine-rich splicing factor 5",null,"SRSF5"]
["19.3183","19.3777","18.9678","19.2139","19.0836","19.8177",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of translation;RNA export from nucleus;termination of RNA polymerase II transcription","mRNA binding;nucleocytoplasmic transporter activity;RNA binding","cytoplasm;cytosol;exon-exon junction complex;microtubule organizing center;nucleolus;nucleoplasm;nucleus","mRNA surveillance pathway;RNA transport",null,null,10,10,10,"24.8","24.8","24.8","57.761",0,"89.7",710540000,78,"0.226556",1,"-0.150448","-0.579161","sp|Q9BZI7|REN3B_HUMAN;tr|A0A087WYC8|A0A087WYC8_HUMAN","sp|Q9BZI7|REN3B_HUMAN;tr|A0A087WYC8|A0A087WYC8_HUMAN",4335,"Q9BZI7","REN3B_HUMAN","Regulator of nonsense transcripts 3B",null,"UPF3B"]
["19.1995","18.1898","19.689","19.3588","18.6135","19.562",{"$nulls":9},7,7,7,"33.2","33.2","33.2","31.905",0,"26.615",117780000,14,"0.103791",1,"-0.152007","-0.288322","tr|F8VYY9|F8VYY9_HUMAN;sp|P54619|AAKG1_HUMAN;tr|H0YHF8|H0YHF8_HUMAN;tr|H0YIC9|H0YIC9_HUMAN;tr|F8VPF5|F8VPF5_HUMAN;tr|F8VVA3|F8VVA3_HUMAN;tr|F8VZX1|F8VZX1_HUMAN;tr|E9PGP6|E9PGP6_HUMAN;sp|Q9UGJ0|AAKG2_HUMAN","tr|F8VYY9|F8VYY9_HUMAN;sp|P54619|AAKG1_HUMAN",1821,"F8VYY9","F8VYY9_HUMAN",null,null,"PRKAG1"]
[1,"12.5934","15.6532",1,"13.195","15.5105",{"$nulls":3},"adaptive immune response;blood vessel morphogenesis;cellular response to UV;development involved in symbiotic interaction;endocardial cushion development;glucocorticoid receptor signaling pathway;lysosomal transport;negative regulation of sodium ion transmembrane transporter activity;negative regulation of sodium ion transport;negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage;negative regulation of vascular endothelial growth factor receptor signaling pathway;neuromuscular junction development;neuron projection development;outflow tract morphogenesis;positive regulation of nucleocytoplasmic transport;positive regulation of phosphatidylinositol 3-kinase signaling;positive regulation of protein catabolic process;progesterone receptor signaling pathway;protein K63-linked ubiquitination;protein monoubiquitination;protein targeting to lysosome;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;receptor catabolic process;receptor internalization;regulation of dendrite morphogenesis;regulation of ion transmembrane transport;regulation of macroautophagy;regulation of membrane potential;regulation of potassium ion transmembrane transporter activity;regulation of synapse organization;response to calcium ion;T cell activation;transmission of virus;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway","beta-2 adrenergic receptor binding;ionotropic glutamate receptor binding;phosphoserine residue binding;phosphothreonine residue binding;proline-rich region binding;protein domain specific binding;RNA polymerase binding;sodium channel inhibitor activity;ubiquitin binding;ubiquitin protein ligase activity","apicolateral plasma membrane;cell cortex;chromatin;cytoplasm;cytosol;dendritic spine;extracellular exosome;Golgi apparatus;perinuclear region of cytoplasm;plasma membrane;ubiquitin ligase complex","Endocytosis;Epstein-Barr virus infection;Tight junction;Ubiquitin mediated proteolysis",null,null,4,4,4,"5.6","5.6","5.6","149.11",0,"18.391",14782000,3,"0.00793148",1,"-0.152958","-0.0241325","sp|P46934|NEDD4_HUMAN;tr|H0Y8X6|H0Y8X6_HUMAN","sp|P46934|NEDD4_HUMAN;tr|H0Y8X6|H0Y8X6_HUMAN",1605,"P46934","NEDD4_HUMAN","E3 ubiquitin-protein ligase NEDD4",null,"NEDD4"]
["15.1855","16.0427","14.8011","15.4933","16.0468","14.9501",{"$nulls":3},"embryo development ending in birth or egg hatching;epithelial cell-cell adhesion;establishment of epithelial cell apical/basal polarity;establishment or maintenance of microtubule cytoskeleton polarity;microtubule anchoring;microtubule cytoskeleton organization;negative regulation of phosphatase activity;neuron projection development;protein transport along microtubule;regulation of cell migration;regulation of focal adhesion assembly;regulation of Golgi organization;regulation of microtubule cytoskeleton organization;regulation of microtubule polymerization;regulation of organelle organization;zonula adherens maintenance","actin filament binding;calmodulin binding;microtubule minus-end binding;spectrin binding","cytoplasm;microtubule;zonula adherens",{"$nulls":3},3,3,3,"5.5","5.5","5.5","134.75",0,"8.8567",53931000,13,"0.115152",1,"-0.153647","-0.317009","sp|Q9P1Y5|CAMP3_HUMAN","sp|Q9P1Y5|CAMP3_HUMAN",4917,"Q9P1Y5","CAMP3_HUMAN","Calmodulin-regulated spectrin-associated protein 3 {ECO:0000305}",null,"CAMSAP3"]
["22.3236","21.3799","22.0869","23.04","21.2065","22.0061",{"$nulls":3},"apoptotic process;blood circulation;cellular response to insulin stimulus;cellular response to interferon-beta;cellular response to interferon-gamma;cellular response to organic cyclic compound;defense response to virus;interferon-gamma-mediated signaling pathway;interleukin-12-mediated signaling pathway;JAK-STAT cascade;macrophage derived foam cell differentiation;metanephric mesenchymal cell differentiation;metanephric mesenchymal cell proliferation involved in metanephros development;negative regulation by virus of viral protein levels in host cell;negative regulation of angiogenesis;negative regulation of endothelial cell proliferation;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;negative regulation of metanephric nephron tubule epithelial cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of defense response to virus by host;positive regulation of erythrocyte differentiation;positive regulation of interferon-alpha production;positive regulation of mesenchymal cell proliferation;positive regulation of nitric-oxide synthase biosynthetic process;positive regulation of smooth muscle cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of apoptotic process;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway;renal tubule development;response to cAMP;response to cytokine;response to drug;response to hydrogen peroxide;response to interferon-beta;response to mechanical stimulus;response to nutrient;response to peptide hormone;transcription, DNA-templated;tumor necrosis factor-mediated signaling pathway;type I interferon signaling pathway;viral process","cadherin binding;CCR5 chemokine receptor binding;core promoter binding;DNA binding transcription factor activity;double-stranded DNA binding;enzyme binding;histone acetyltransferase binding;histone binding;identical protein binding;nuclear hormone receptor binding;promoter-specific chromatin binding;protein homodimerization activity;protein phosphatase 2A binding;repressing transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;signal transducer activity;transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;tumor necrosis factor receptor binding;ubiquitin-like protein ligase binding","axon;cytoplasm;cytosol;dendrite;nuclear chromatin;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex","AGE-RAGE signaling pathway in diabetic complications;Chemokine signaling pathway;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human papillomavirus infection;Inflammatory bowel disease (IBD);Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Prolactin signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis",null,null,27,27,27,"45.3","45.3","45.3","87.334",0,"187.26",1770300000,112,"0.0912429",1,"-0.15409","-0.256096","sp|P42224|STAT1_HUMAN;tr|J3KPM9|J3KPM9_HUMAN;tr|E7EPD2|E7EPD2_HUMAN;tr|D2KFR9|D2KFR9_HUMAN;tr|E7ENM1|E7ENM1_HUMAN;tr|E9PH66|E9PH66_HUMAN;tr|H7BZB5|H7BZB5_HUMAN;tr|H7BZ88|H7BZ88_HUMAN","sp|P42224|STAT1_HUMAN;tr|J3KPM9|J3KPM9_HUMAN",1544,"P42224","STAT1_HUMAN","Signal transducer and activator of transcription 1-alpha/beta",null,"STAT1"]
["20.2267","16.2912","20.6665","20.551","16.5056","20.5937",{"$nulls":4},"DNA binding transcription factor activity;sequence-specific DNA binding","cytosol;nucleoplasm",{"$nulls":3},4,4,4,"9.9","9.9","9.9","53.593",0,"17.529",199600000,14,"0.0268193",1,"-0.155294","-0.0799539","tr|E9PMQ6|E9PMQ6_HUMAN;sp|Q00613|HSF1_HUMAN;tr|A0A087X1F9|A0A087X1F9_HUMAN;tr|E9PI02|E9PI02_HUMAN","tr|E9PMQ6|E9PMQ6_HUMAN;sp|Q00613|HSF1_HUMAN;tr|A0A087X1F9|A0A087X1F9_HUMAN;tr|E9PI02|E9PI02_HUMAN",2121,"E9PMQ6","E9PMQ6_HUMAN",null,null,"HSF1"]
["23.9252","22.06","23.4762","24.2281","22.3812","23.3184",{"$nulls":3},"immune response;inosine catabolic process;interleukin-2 secretion;NAD biosynthesis via nicotinamide riboside salvage pathway;neutrophil degranulation;nicotinamide riboside catabolic process;nucleobase-containing compound metabolic process;positive regulation of alpha-beta T cell differentiation;positive regulation of T cell proliferation;purine nucleotide catabolic process;purine-containing compound salvage;response to drug;urate biosynthetic process","drug binding;nucleoside binding;phosphate ion binding;purine nucleobase binding;purine-nucleoside phosphorylase activity","cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular;nucleus;secretory granule lumen","Metabolic pathways;Nicotinate and nicotinamide metabolism;Purine metabolism;Pyrimidine metabolism",null,null,16,16,16,"76.8","76.8","76.8","32.118",0,"215.32",2081100000,113,"0.0701886",1,"-0.155438","-0.200641","sp|P00491|PNPH_HUMAN;tr|G3V5M2|G3V5M2_HUMAN;tr|G3V2H3|G3V2H3_HUMAN;tr|G3V393|G3V393_HUMAN","sp|P00491|PNPH_HUMAN;tr|G3V5M2|G3V5M2_HUMAN",828,"P00491","PNPH_HUMAN","Purine nucleoside phosphorylase","NP","PNP"]
["16.8923","14.3238","16.1895","15.9241","14.8018","17.1507",{"$nulls":3},"cellular response to DNA damage stimulus;chromatin remodeling;DNA repair;global genome nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization","ATP binding;ATPase activity;ATP-dependent DNA helicase activity;nucleotide binding","cytosol;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},10,10,10,"12.5","12.5","12.5","100.98",0,"31.918",162450000,31,"0.0528057",1,"-0.156993","-0.153398","sp|Q86WJ1|CHD1L_HUMAN;tr|A0A0A0MSH9|A0A0A0MSH9_HUMAN;tr|A0A0A0MRH8|A0A0A0MRH8_HUMAN;tr|A0A087WTM4|A0A087WTM4_HUMAN;tr|A0A087WWW4|A0A087WWW4_HUMAN","sp|Q86WJ1|CHD1L_HUMAN;tr|A0A0A0MSH9|A0A0A0MSH9_HUMAN;tr|A0A0A0MRH8|A0A0A0MRH8_HUMAN;tr|A0A087WTM4|A0A087WTM4_HUMAN",3244,"Q86WJ1","CHD1L_HUMAN","Chromodomain-helicase-DNA-binding protein 1-like",null,"CHD1L"]
["22.4298","20.6797","22.1866","22.4302","20.9129","22.4251",{"$nulls":3},"protein import into nucleus","histone binding;protein transporter activity;Ran GTPase binding","cytoplasm;cytosol;membrane;nuclear envelope",{"$nulls":3},25,25,25,"35.4","35.4","35.4","115.96",0,"323.31",1619200000,148,"0.0741923",1,"-0.15737","-0.211328","sp|Q96P70|IPO9_HUMAN","sp|Q96P70|IPO9_HUMAN",3990,"Q96P70","IPO9_HUMAN","Importin-9","mp9","IPO9"]
["19.1682","18.1979","19.1412","19.9157","17.9174","19.1494",{"$nulls":3},"DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;gene silencing by RNA;negative regulation of translation;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;nuclear-transcribed mRNA poly(A) tail shortening;regulation of stem cell population maintenance;regulation of transcription, DNA-templated;transcription, DNA-templated;trophectodermal cell differentiation",null,"CCR4-NOT complex;CCR4-NOT core complex;cytosol;nucleus;P-body","RNA degradation",null,null,4,4,4,"6.6","6.6","6.6","81.871",0,"10.124",146140000,12,"0.0845327",1,"-0.158381","-0.238618","sp|O75175|CNOT3_HUMAN;tr|H0Y5X7|H0Y5X7_HUMAN;tr|H7C3F5|H7C3F5_HUMAN;tr|H7C5J4|H7C5J4_HUMAN;tr|A0A0G2JPP0|A0A0G2JPP0_HUMAN","sp|O75175|CNOT3_HUMAN;tr|H0Y5X7|H0Y5X7_HUMAN;tr|H7C3F5|H7C3F5_HUMAN",556,"O75175","CNOT3_HUMAN","CCR4-NOT transcription complex subunit 3",null,"CNOT3"]
["20.0087","18.3722","18.2616","19.926","18.4156","18.7823",{"$nulls":4},"ATP binding","cytosol;nucleoplasm",{"$nulls":3},11,11,11,"18.3","18.3","18.3","107.43",0,"48.696",346500000,62,"0.0779373",1,"-0.160457","-0.221263","tr|E7EXA6|E7EXA6_HUMAN;sp|Q8WVB6|CTF18_HUMAN;tr|A0A0D9SF58|A0A0D9SF58_HUMAN;tr|F8WCC1|F8WCC1_HUMAN;tr|H0Y7D3|H0Y7D3_HUMAN","tr|E7EXA6|E7EXA6_HUMAN;sp|Q8WVB6|CTF18_HUMAN;tr|A0A0D9SF58|A0A0D9SF58_HUMAN",3614,"E7EXA6","E7EXA6_HUMAN",null,null,"CHTF18"]
["19.6964","17.7346","19.064","20.1181","17.5667","19.296",{"$nulls":3},"angiogenesis;signal transduction","receptor tyrosine kinase binding",{"$nulls":4},5,5,5,"31.3","31.3","31.3","32.507",0,"15.881",114790000,22,"0.0591149",1,"-0.161905","-0.170708","tr|H0Y539|H0Y539_HUMAN;tr|X6R6D0|X6R6D0_HUMAN;sp|P29353|SHC1_HUMAN;tr|Q5T188|Q5T188_HUMAN","tr|H0Y539|H0Y539_HUMAN;tr|X6R6D0|X6R6D0_HUMAN;sp|P29353|SHC1_HUMAN;tr|Q5T188|Q5T188_HUMAN",1356,"H0Y539","H0Y539_HUMAN",null,null,"SHC1"]
["16.3095","17.1963","17.2891","17.779","17.1306","16.3738",{"$nulls":3},"cell cycle;cell division;maintenance of centrosome location;posttranscriptional regulation of gene expression;production of miRNAs involved in gene silencing by miRNA","methyltransferase activity;miRNA binding;RNA binding","condensed chromosome kinetochore;cytoplasm;kinetochore;mitotic spindle;spindle pole centrosome",{"$nulls":3},10,10,10,"33.8","33.8","33.8","42.008",0,"44.759",350140000,35,"0.115507",1,"-0.162829","-0.317899","sp|Q5T280|CI114_HUMAN;tr|A0A087WYA7|A0A087WYA7_HUMAN;tr|R4GNG4|R4GNG4_HUMAN","sp|Q5T280|CI114_HUMAN",2866,"Q5T280","CI114_HUMAN","Putative methyltransferase C9orf114 {ECO:0000305}",null,"SPOUT1"]
["19.9732","17.6718","19.0007","18.9159","18.738","19.4928",{"$nulls":3},"positive regulation of translation;positive regulation of translational initiation","N6-methyladenosine-containing RNA binding;ribosome binding;RNA binding","cytoplasm",{"$nulls":3},6,3,3,"16.8","11.1","11.1","60.873",0,"14.447",126730000,18,"0.0838608",1,"-0.166946","-0.236859","sp|Q9BYJ9|YTHD1_HUMAN","sp|Q9BYJ9|YTHD1_HUMAN",4315,"Q9BYJ9","YTHD1_HUMAN","YTH domain-containing family protein 1 {ECO:0000305}",null,"YTHDF1"]
["24.4068","22.0863","23.696","24.4724","22.3523","23.8692",{"$nulls":3},"positive regulation of translation;regulation of translation;RNA processing","RNA binding","cytoplasm;dendrite;nucleolus;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"55.4","55.4","55.4","17.17",0,"227.88",870590000,40,"0.0627154",1,"-0.168258","-0.180501","sp|P98179|RBM3_HUMAN","sp|P98179|RBM3_HUMAN",2109,"P98179","RBM3_HUMAN","RNA-binding protein 3",null,"RBM3"]
["25.3428","23.2379","25.0529","25.3277","23.4377","25.3738",{"$nulls":3},"dosage compensation by inactivation of X chromosome;regulation of translational initiation;response to stress","RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;nucleus","RNA transport",null,null,6,6,6,"63.7","63.7","63.7","12.732",0,"280.66",1297000000,44,"0.0639482",1,"-0.168557","-0.183841","sp|P41567|EIF1_HUMAN;tr|K7EM18|K7EM18_HUMAN;sp|O60739|EIF1B_HUMAN;tr|K7EQP2|K7EQP2_HUMAN","sp|P41567|EIF1_HUMAN;tr|K7EM18|K7EM18_HUMAN;sp|O60739|EIF1B_HUMAN",1538,"P41567","EIF1_HUMAN","Eukaryotic translation initiation factor 1","IF1","EIF1"]
["23.2306","21.0662","22.2793","22.6603","22.0486","22.3828",{"$nulls":3},"mitochondrion organization;positive regulation of transcription from RNA polymerase II promoter;regulation of cellular response to hypoxia;transcription, DNA-templated","sequence-specific DNA binding;transcription factor binding","mitochondrial intermembrane space;mitochondrion;nucleus",{"$nulls":3},3,3,3,"27.2","27.2","27.2","15.512",0,"58.914",275980000,28,"0.0943447",1,"-0.17189","-0.264117","sp|Q9Y6H1|CHCH2_HUMAN;sp|Q5T1J5|CHCH9_HUMAN","sp|Q9Y6H1|CHCH2_HUMAN;sp|Q5T1J5|CHCH9_HUMAN",2863,"Q9Y6H1","CHCH2_HUMAN","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2",null,"CHCHD2"]
["20.3279","19.9464","20.6621","21.3718","19.4784","20.603",{"$nulls":3},"oxidation-reduction process;retinol metabolic process","all-trans-retinol 13,14-reductase activity;oxidoreductase activity","endoplasmic reticulum membrane;membrane;nuclear membrane;nuclear outer membrane","Retinol metabolism",null,null,14,14,14,"28.5","28.5","28.5","66.819",0,"65.292",481820000,43,"0.105758",1,"-0.172291","-0.293321","sp|Q6NUM9|RETST_HUMAN;tr|H7C3J0|H7C3J0_HUMAN;tr|H7BZ81|H7BZ81_HUMAN;tr|H7BZ16|H7BZ16_HUMAN;tr|H0YGU3|H0YGU3_HUMAN","sp|Q6NUM9|RETST_HUMAN;tr|H7C3J0|H7C3J0_HUMAN;tr|H7BZ81|H7BZ81_HUMAN",2979,"Q6NUM9","RETST_HUMAN","All-trans-retinol 13,14-reductase",null,"RETSAT"]
["14.3637",1,"13.8138",1,"12.9946","15.7069",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cellular response to estradiol stimulus;male meiotic nuclear division;microtubule depolymerization;microtubule-based movement;mitotic metaphase plate congression;protein transport;regulation of microtubule cytoskeleton organization;retrograde vesicle-mediated transport, Golgi to ER;seminiferous tubule development;sister chromatid cohesion","actin binding;ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;microtubule binding;microtubule plus-end binding;tubulin-dependent ATPase activity","caveola;cytoplasm;cytosol;kinesin complex;kinetochore;kinetochore microtubule;microtubule cytoskeleton;microtubule organizing center;mitotic spindle midzone;nucleus;ruffle",{"$nulls":3},7,7,7,"11.1","11.1","11.1","102.28",0,"17.555",87848000,17,"0.00914865",1,"-0.17466","-0.0277981","sp|Q8NI77|KI18A_HUMAN;tr|A0A0C4DGP2|A0A0C4DGP2_HUMAN;tr|A0A0C4DGP5|A0A0C4DGP5_HUMAN;sp|Q86Y91|KI18B_HUMAN","sp|Q8NI77|KI18A_HUMAN",3522,"Q8NI77","KI18A_HUMAN","Kinesin-like protein KIF18A",null,"KIF18A"]
["20.5121",1,"20.3703","21.1626",1,"20.2498",{"$nulls":3},"chaperone-mediated protein transport;protein import into mitochondrial inner membrane;protein targeting to mitochondrion;sensory perception of sound","protein transporter activity;zinc ion binding","fibrillar center;mitochondrial inner membrane;mitochondrial intermembrane space protein transporter complex;mitochondrion",{"$nulls":3},2,2,2,"25.3","25.3","25.3","10.5",0,"11.643",65356000,6,"0.00627884",1,"-0.176681","-0.0191395","sp|Q9Y5L4|TIM13_HUMAN;tr|K7EIT2|K7EIT2_HUMAN","sp|Q9Y5L4|TIM13_HUMAN;tr|K7EIT2|K7EIT2_HUMAN",5358,"Q9Y5L4","TIM13_HUMAN","Mitochondrial import inner membrane translocase subunit Tim13",null,"TIMM13"]
["15.8873","15.7026","16.1095","17.2784","15.3013","15.6524",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity",{"$nulls":4},2,2,2,"4.4","4.4","4.4","138.58",0,"30.347",31521000,8,"0.102981",1,"-0.177557","-0.286259","tr|H0Y494|H0Y494_HUMAN;tr|J3KPC8|J3KPC8_HUMAN;sp|Q9Y2K2|SIK3_HUMAN;tr|H0Y4E8|H0Y4E8_HUMAN","tr|H0Y494|H0Y494_HUMAN;tr|J3KPC8|J3KPC8_HUMAN;sp|Q9Y2K2|SIK3_HUMAN;tr|H0Y4E8|H0Y4E8_HUMAN",5559,"H0Y494","H0Y494_HUMAN",null,null,"SIK3"]
["17.2167","15.9806","18.4025","18.7005","16.5773","16.8594",{"$nulls":3},"brain development;mitochondrial tRNA modification;negative regulation of cyclin-dependent protein serine/threonine kinase activity;positive regulation of mitochondrial translation;positive regulation of translational fidelity;regulation of neuron differentiation","4 iron, 4 sulfur cluster binding;metal ion binding;N6-isopentenyladenosine methylthiotransferase activity;protein complex binding;protein kinase binding","mitochondrion",{"$nulls":3},6,6,6,"13.5","13.5","13.5","67.688",0,"22.371",86173000,20,"0.0645726",1,"-0.179118","-0.18553","sp|Q96SZ6|CK5P1_HUMAN;tr|H0Y721|H0Y721_HUMAN","sp|Q96SZ6|CK5P1_HUMAN;tr|H0Y721|H0Y721_HUMAN",4047,"Q96SZ6","CK5P1_HUMAN","CDK5 regulatory subunit-associated protein 1",null,"CDK5RAP1"]
["19.0262","16.9689","18.5737","19.271","17.0235","18.8178",{"$nulls":3},"microtubule-based movement","ATP binding;ATPase activity;microtubule binding;microtubule motor activity","cytoplasm;kinesin complex;microtubule",{"$nulls":3},15,15,15,"13.8","13.8","13.8","187.18",0,"101.54",268780000,39,"0.0681892",1,"-0.181145","-0.195277","sp|Q7Z4S6|KI21A_HUMAN;tr|H0YHT2|H0YHT2_HUMAN;tr|H0YIM7|H0YIM7_HUMAN;tr|H0YIM6|H0YIM6_HUMAN;tr|H0YI78|H0YI78_HUMAN;tr|H0YHG9|H0YHG9_HUMAN;sp|O75037|KI21B_HUMAN","sp|Q7Z4S6|KI21A_HUMAN",3171,"Q7Z4S6","KI21A_HUMAN","Kinesin-like protein KIF21A",null,"KIF21A"]
["20.1695","19.1471","19.2593","20.6559","18.9541","19.515",{"$nulls":3},"regulation of transcription, DNA-templated",null,"cytosol;nucleus;plasma membrane",{"$nulls":3},8,8,8,"32.6","32.6","32.6","58.62",0,"51.636",245830000,19,"0.111185",1,"-0.183063","-0.307042","tr|F8VV52|F8VV52_HUMAN;sp|Q9NZN8|CNOT2_HUMAN;tr|F8W145|F8W145_HUMAN;tr|F8VP97|F8VP97_HUMAN;tr|F8VRS8|F8VRS8_HUMAN;tr|A0A087X050|A0A087X050_HUMAN;tr|F8VVY1|F8VVY1_HUMAN;tr|F8VUB4|F8VUB4_HUMAN;tr|F8VX63|F8VX63_HUMAN;tr|F8VWH8|F8VWH8_HUMAN;tr|F8VQD8|F8VQD8_HUMAN;tr|F8VQF4|F8VQF4_HUMAN;tr|H0YI11|H0YI11_HUMAN;tr|H0YH84|H0YH84_HUMAN","tr|F8VV52|F8VV52_HUMAN;sp|Q9NZN8|CNOT2_HUMAN;tr|F8W145|F8W145_HUMAN;tr|F8VP97|F8VP97_HUMAN;tr|F8VRS8|F8VRS8_HUMAN",4887,"F8VV52","F8VV52_HUMAN",null,null,"CNOT2"]
["20.0021","15.7696","20.3158","20.0876","15.8206","20.7367",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosomal small subunit biogenesis;rRNA base methylation;rRNA processing","RNA binding;rRNA (pseudouridine) methyltransferase activity;rRNA binding","cytoplasm;nucleolus;nucleoplasm;nucleus;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,5,5,5,"25.8","25.8","25.8","26.72",0,"14.82",229260000,19,"0.0293649",1,"-0.185761","-0.0873118","sp|Q92979|NEP1_HUMAN;tr|V9GYP5|V9GYP5_HUMAN;tr|A0A087WWQ2|A0A087WWQ2_HUMAN;tr|A0A087WVM7|A0A087WVM7_HUMAN","sp|Q92979|NEP1_HUMAN;tr|V9GYP5|V9GYP5_HUMAN;tr|A0A087WWQ2|A0A087WWQ2_HUMAN",3746,"Q92979","NEP1_HUMAN","Ribosomal RNA small subunit methyltransferase NEP1 {ECO:0000305|PubMed:20047967}",null,"EMG1"]
["18.7869","17.8928","18.3644","17.0444","19.2687","19.2904",{"$nulls":3},"maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);negative regulation of cell migration;negative regulation of cell proliferation;negative regulation of cell-cell adhesion;negative regulation of collagen binding;negative regulation of DNA replication;negative regulation of protein ubiquitination;osteoblast differentiation;protein stabilization;regulation of cyclin-dependent protein serine/threonine kinase activity","GTP binding;GTPase activity;RNA binding","cytoplasm;cytosol;Golgi apparatus;membrane;nuclear membrane;nucleolus;nucleus;perinuclear region of cytoplasm","Ribosome biogenesis in eukaryotes",null,null,26,26,26,"46.8","46.8","46.8","73.964",0,"230.78",2141400000,132,"0.0837269",1,"-0.186501","-0.236508","sp|Q9BZE4|NOG1_HUMAN;tr|Q5T3R7|Q5T3R7_HUMAN","sp|Q9BZE4|NOG1_HUMAN",4328,"Q9BZE4","NOG1_HUMAN","Nucleolar GTP-binding protein 1",null,"GTPBP4"]
["21.115","20.2013","20.6275","21.0323","20.9259","20.5499",{"$nulls":3},"post-translational protein modification","transcription factor binding;ubiquitin binding;ubiquitin protein ligase binding","cytosol;nuclear body;nucleoplasm;VCP-NPL4-UFD1 AAA ATPase complex",{"$nulls":3},10,10,9,"27.8","27.8","25.2","54.862",0,"59.448",396700000,21,"0.246567",1,"-0.188142","-0.623405","sp|O94888|UBXN7_HUMAN;tr|C9JAT7|C9JAT7_HUMAN;tr|C9JD50|C9JD50_HUMAN;tr|H7BYF4|H7BYF4_HUMAN","sp|O94888|UBXN7_HUMAN;tr|C9JAT7|C9JAT7_HUMAN",687,"O94888","UBXN7_HUMAN","UBX domain-containing protein 7",null,"UBXN7"]
["22.0816","20.7083","21.6937","22.4365","20.6622","21.9559",{"$nulls":3},"cell cycle arrest;cell death;cellular macromolecule biosynthetic process;negative regulation of autophagy;positive regulation of cell growth;regulation of translational initiation","cadherin binding;RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cell-cell adherens junction;cytosol;eukaryotic translation initiation factor 4F complex;membrane","RNA transport;Viral myocarditis",null,null,32,32,32,45,45,45,"102.36",0,"227.36",1682000000,140,"0.102277",1,"-0.19035","-0.284463","sp|P78344|IF4G2_HUMAN;tr|D3DQV9|D3DQV9_HUMAN;tr|H0Y3P2|H0Y3P2_HUMAN;tr|H0YCH5|H0YCH5_HUMAN;tr|E9PKF8|E9PKF8_HUMAN;tr|H0YE22|H0YE22_HUMAN;tr|H0YD77|H0YD77_HUMAN;tr|H0YEC5|H0YEC5_HUMAN;tr|H0YCF8|H0YCF8_HUMAN;tr|H0YD99|H0YD99_HUMAN;tr|H0YE44|H0YE44_HUMAN;tr|H0YEN8|H0YEN8_HUMAN;tr|H0YDC0|H0YDC0_HUMAN","sp|P78344|IF4G2_HUMAN;tr|D3DQV9|D3DQV9_HUMAN;tr|H0Y3P2|H0Y3P2_HUMAN",2055,"P78344","IF4G2_HUMAN","Eukaryotic translation initiation factor 4 gamma 2","IF4G 2;IF-4G 2;IF-4-gamma 2","EIF4G2"]
["20.1487","18.1245","19.4724","20.5335","17.9097","19.8797",{"$nulls":3},"negative regulation of adiponectin secretion;protein transport;regulated exocytosis","Rab GTPase binding","cytoplasm;cytosol;intracellular membrane-bounded organelle;phagocytic vesicle membrane;recycling endosome","Endocytosis",null,null,36,36,34,"42.2","42.2","40.3","137.17",0,"323.31",3195700000,234,"0.0680045",1,"-0.192406","-0.194781","sp|Q6WKZ4|RFIP1_HUMAN;tr|E7EX40|E7EX40_HUMAN","sp|Q6WKZ4|RFIP1_HUMAN;tr|E7EX40|E7EX40_HUMAN",3069,"Q6WKZ4","RFIP1_HUMAN","Rab11 family-interacting protein 1","ab11-FIP1","RAB11FIP1"]
[1,"14.6691","14.8262","15.5878",1,"14.4882",{"$nulls":9},2,2,2,"2.5","2.5","2.5","134.63","0.00081716","3.9208",15593000,2,"0.00972194",1,"-0.193581","-0.0295212","sp|Q9P260|K1468_HUMAN;tr|A0A075B768|A0A075B768_HUMAN","sp|Q9P260|K1468_HUMAN;tr|A0A075B768|A0A075B768_HUMAN",4923,"Q9P260","K1468_HUMAN","LisH domain and HEAT repeat-containing protein KIAA1468",null,"KIAA1468"]
["20.5907","19.602","20.5642","20.3301","20.4441","20.5692",{"$nulls":3},"generation of precursor metabolites and energy;glycogen biosynthetic process;glycogen metabolic process","1,4-alpha-glucan branching enzyme activity;1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis);carbohydrate binding;cation binding;hydrolase activity, hydrolyzing O-glycosyl compounds","cytosol;extracellular exosome","Metabolic pathways;Starch and sucrose metabolism",null,null,13,13,13,"20.8","20.8","20.8","80.473",0,"51.712",511320000,31,"0.230585",1,"-0.19554","-0.588125","sp|Q04446|GLGB_HUMAN;tr|E9PGM4|E9PGM4_HUMAN","sp|Q04446|GLGB_HUMAN;tr|E9PGM4|E9PGM4_HUMAN",2184,"Q04446","GLGB_HUMAN","1,4-alpha-glucan-branching enzyme",null,"GBE1"]
["21.3857","19.4453","21.3568","21.9001","19.4921","21.3866",{"$nulls":9},13,13,13,"46.6","46.6","46.6","52.175",0,"131.1",544040000,55,"0.0708061",1,"-0.197003","-0.202293","tr|F6T1Q0|F6T1Q0_HUMAN;sp|Q6L8Q7|PDE12_HUMAN","tr|F6T1Q0|F6T1Q0_HUMAN;sp|Q6L8Q7|PDE12_HUMAN",2971,"F6T1Q0","F6T1Q0_HUMAN",null,null,"PDE12"]
["17.7441","17.914","16.9651","17.7473","17.4986","17.9743",{"$nulls":3},"cellular protein modification process;hydroxylysine biosynthetic process;peptidyl-lysine hydroxylation;response to hypoxia","iron ion binding;L-ascorbic acid binding;procollagen-lysine 5-dioxygenase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;rough endoplasmic reticulum membrane","Lysine degradation",null,null,7,7,7,"11.5","11.5","11.5","84.685",0,"12.11",109930000,10,"0.243424",1,"-0.199015","-0.616502","sp|O00469|PLOD2_HUMAN;tr|E7ETU9|E7ETU9_HUMAN;tr|C9JXZ0|C9JXZ0_HUMAN;tr|F8WEW3|F8WEW3_HUMAN","sp|O00469|PLOD2_HUMAN;tr|E7ETU9|E7ETU9_HUMAN",243,"O00469","PLOD2_HUMAN","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2",null,"PLOD2"]
["17.0129","15.7461","17.3485","17.4448","16.2621","17.0027",{"$nulls":3},"intracellular signal transduction","GTPase activator activity;metal ion binding","intracellular",{"$nulls":3},2,2,2,4,4,4,"84.622",0,"10.615",52335000,8,"0.12273",1,"-0.200734","-0.335904","tr|K7ES92|K7ES92_HUMAN;tr|F5H1R4|F5H1R4_HUMAN;sp|Q92619|HMHA1_HUMAN;tr|K7ES98|K7ES98_HUMAN;tr|K7EM85|K7EM85_HUMAN","tr|K7ES92|K7ES92_HUMAN;tr|F5H1R4|F5H1R4_HUMAN;sp|Q92619|HMHA1_HUMAN;tr|K7ES98|K7ES98_HUMAN;tr|K7EM85|K7EM85_HUMAN",3694,"K7ES92","K7ES92_HUMAN",null,null,"ARHGAP45"]
["26.3832","25.0024","26.1329","26.5792","25.1876","26.3568",{"$nulls":3},"nuclear-transcribed mRNA poly(A) tail shortening;regulation of gene expression;RNA secondary structure unwinding;translational initiation;viral process","ATP binding;ATP-dependent RNA helicase activity;double-stranded RNA binding;helicase activity;mRNA binding;RNA binding;RNA cap binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 4F complex;extracellular exosome;extracellular matrix;membrane","RNA transport",null,null,28,28,17,"75.9","75.9","50.2","46.153",0,"323.31",16659000000,403,"0.121579",1,"-0.201677","-0.333046","sp|P60842|IF4A1_HUMAN;tr|J3KT12|J3KT12_HUMAN;tr|J3QS69|J3QS69_HUMAN;tr|J3KTB5|J3KTB5_HUMAN;tr|J3QL43|J3QL43_HUMAN;tr|J3QR64|J3QR64_HUMAN;tr|J3QLN6|J3QLN6_HUMAN;tr|J3KS25|J3KS25_HUMAN;tr|J3KSZ0|J3KSZ0_HUMAN;tr|J3QKZ9|J3QKZ9_HUMAN;tr|J3KTN0|J3KTN0_HUMAN;tr|J3KT04|J3KT04_HUMAN;tr|J3KS93|J3KS93_HUMAN;tr|J3QQP0|J3QQP0_HUMAN;tr|J3QL52|J3QL52_HUMAN","sp|P60842|IF4A1_HUMAN;tr|J3KT12|J3KT12_HUMAN;tr|J3QS69|J3QS69_HUMAN;tr|J3KTB5|J3KTB5_HUMAN;tr|J3QL43|J3QL43_HUMAN;tr|J3QR64|J3QR64_HUMAN",1899,"P60842","IF4A1_HUMAN","Eukaryotic initiation factor 4A-I","IF4A-I;IF-4A-I","EIF4A1"]
["19.2527","16.7824","19.502","19.391","17.4758","19.279",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly;skeletal muscle cell differentiation;transcription from RNA polymerase III promoter;transcription from RNA polymerase III type 2 promoter;transcription, DNA-templated;tRNA transcription from RNA polymerase III promoter","DNA binding","nucleoplasm;transcription factor TFIIIC complex",{"$nulls":3},15,15,15,"37.8","37.8","37.8","59.57",0,"66.944",558950000,90,"0.0662828",1,"-0.202885","-0.190146","sp|Q9Y5Q8|TF3C5_HUMAN;tr|Q5T7U1|Q5T7U1_HUMAN;tr|H7BY84|H7BY84_HUMAN;tr|Q5T7U0|Q5T7U0_HUMAN;tr|Q5T7U4|Q5T7U4_HUMAN;tr|H0Y5D2|H0Y5D2_HUMAN","sp|Q9Y5Q8|TF3C5_HUMAN;tr|Q5T7U1|Q5T7U1_HUMAN;tr|H7BY84|H7BY84_HUMAN",5363,"Q9Y5Q8","TF3C5_HUMAN","General transcription factor 3C polypeptide 5",null,"GTF3C5"]
["23.9759","23.2857","23.8166","24.4409","23.1252","24.1275",{"$nulls":3},"cytokine secretion;interleukin-1 alpha secretion;mast cell degranulation;positive regulation of cell proliferation;positive regulation of I-kappaB kinase/NF-kappaB signaling;regulation of cell shape;response to copper ion;response to electrical stimulus","calcium ion binding;copper ion binding;fibroblast growth factor binding;lipid binding;protein homodimerization activity;RAGE receptor binding;zinc ion binding","cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;mast cell granule;nucleolus;nucleus;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},5,5,5,"65.3","65.3","65.3","11.471",0,"27.036",963600000,37,"0.173304",1,"-0.205159","-0.457651","sp|Q99584|S10AD_HUMAN","sp|Q99584|S10AD_HUMAN",4083,"Q99584","S10AD_HUMAN","Protein S100-A13",null,"S100A13"]
["17.9197","15.4622",1,"18.5489","15.4538",1,{"$nulls":3},"arginine catabolic process;citrulline metabolic process;negative regulation of apoptotic process;nitric oxide biosynthetic process;nitric oxide mediated signal transduction;positive regulation of nitric oxide biosynthetic process;regulation of nitric-oxide synthase activity","amino acid binding;catalytic activity;dimethylargininase activity","cytosol;extracellular exosome;microtubule organizing center;mitochondrion",{"$nulls":3},3,2,2,"15.1","12.3","12.3","29.644",0,"8.8921",29023000,2,"0.00901196",1,"-0.206961","-0.0273869","sp|O95865|DDAH2_HUMAN;tr|H0Y7N1|H0Y7N1_HUMAN;tr|Q5SSV3|Q5SSV3_HUMAN;tr|Q5SRR8|Q5SRR8_HUMAN","sp|O95865|DDAH2_HUMAN;tr|H0Y7N1|H0Y7N1_HUMAN;tr|Q5SSV3|Q5SSV3_HUMAN;tr|Q5SRR8|Q5SRR8_HUMAN",802,"O95865","DDAH2_HUMAN","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2","DAH-2;imethylarginine dimethylaminohydrolase 2","DDAH2"]
["23.8994","22.8741","24.1636","23.7296","23.5729","24.2595",{"$nulls":3},"cell cycle;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination",null,"nuclear body;nucleus",{"$nulls":3},8,8,8,"36.5","36.5","36.5","18.925",0,"79.977",1567900000,55,"0.177868",1,"-0.208279","-0.468308","sp|Q8WW12|PCNP_HUMAN","sp|Q8WW12|PCNP_HUMAN",3629,"Q8WW12","PCNP_HUMAN","PEST proteolytic signal-containing nuclear protein","CNP;EST-containing nuclear protein","PCNP"]
["17.578","17.3142","17.4193","18.0434","17.8059","17.0909",{"$nulls":3},"multicellular organism development;pigmentation;Wnt signaling pathway, planar cell polarity pathway",null,"integral component of membrane;lateral plasma membrane","Wnt signaling pathway",null,null,15,15,15,"36.8","36.8","36.8","59.974",0,"62.865",925080000,87,"0.285318",1,"-0.209587","-0.707282","sp|Q8TAA9|VANG1_HUMAN","sp|Q8TAA9|VANG1_HUMAN",3525,"Q8TAA9","VANG1_HUMAN","Vang-like protein 1",null,"VANGL1"]
["25.794","25.0525","25.4916","26.3145","25.0526","25.6029",{"$nulls":3},"aging;cardiac muscle cell differentiation;cellular response to calcium ion;cellular response to leukemia inhibitory factor;negative regulation of cell death;positive regulation of DNA replication;response to growth hormone","protein domain specific binding;protein homodimerization activity;ubiquitin protein ligase binding","beta-catenin destruction complex;cell body;cytosol;extracellular exosome;neuron projection;nuclear envelope lumen;nucleoplasm;SCF ubiquitin ligase complex","Wnt signaling pathway",null,null,14,14,14,"56.6","56.6","56.6","26.21",0,"228.02",6766900000,184,"0.190189",1,"-0.210638","-0.496832","sp|Q9HB71|CYBP_HUMAN;tr|B2ZWH1|B2ZWH1_HUMAN","sp|Q9HB71|CYBP_HUMAN",4570,"Q9HB71","CYBP_HUMAN","Calcyclin-binding protein","acyBP;CacyBP","CACYBP"]
["22.8908","21.9811","23.1426","23.3472","22.2695","23.0349",{"$nulls":3},"intracellular protein transport;retrograde transport, endosome to Golgi;retrograde transport, endosome to plasma membrane;Wnt signaling pathway","zinc ion binding","cytosol;early endosome;endosome;endosome membrane;extracellular exosome;intracellular membrane-bounded organelle;late endosome;retromer complex;retromer, cargo-selective complex","Endocytosis",null,null,9,9,9,"60.4","60.4","60.4","20.505",0,"64.246",727020000,36,"0.16823",1,"-0.212355","-0.445745","sp|Q9UBQ0|VPS29_HUMAN;tr|F8VXU5|F8VXU5_HUMAN;tr|Q05DG7|Q05DG7_HUMAN","sp|Q9UBQ0|VPS29_HUMAN;tr|F8VXU5|F8VXU5_HUMAN",4967,"Q9UBQ0","VPS29_HUMAN","Vacuolar protein sorting-associated protein 29","VPS29","VPS29"]
["16.8539",1,"17.1439","17.5762",1,"17.0609",{"$nulls":4},"lipid binding",{"$nulls":4},2,2,2,"5.7","5.7","5.7","46.643","0.00081384","3.8569",23495000,5,"0.00920442",1,"-0.213088","-0.0279658","sp|Q9UDX3|S14L4_HUMAN;tr|D7F472|D7F472_HUMAN;tr|F8WEM2|F8WEM2_HUMAN","sp|Q9UDX3|S14L4_HUMAN;tr|D7F472|D7F472_HUMAN;tr|F8WEM2|F8WEM2_HUMAN",4984,"Q9UDX3","S14L4_HUMAN","SEC14-like protein 4",null,"SEC14L4"]
["24.4944","21.8317","22.5632","24.3277","21.9983","23.2049",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein K63-linked deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of proteasomal protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to ethanol;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent protein catabolic process;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activator activity;Lys63-specific deubiquitinase activity;metal ion binding;metallopeptidase activity;proteasome binding;thiol-dependent ubiquitinyl hydrolase activity","cytosol;cytosolic proteasome complex;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, lid subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,10,10,10,"48.7","48.7","48.7","34.577",0,"157.48",1428800000,68,"0.0720041",1,"-0.213868","-0.205495","sp|O00487|PSDE_HUMAN;tr|C9JW37|C9JW37_HUMAN","sp|O00487|PSDE_HUMAN",246,"O00487","PSDE_HUMAN","26S proteasome non-ATPase regulatory subunit 14",null,"PSMD14"]
["18.6367","17.7788","17.7259","18.8719","17.7643","18.1505",{"$nulls":3},"negative regulation of proteasomal protein catabolic process;negative regulation of skeletal muscle tissue development;positive regulation of cell cycle process;protein deubiquitination;protein stabilization;regulation of cellular response to hypoxia;regulation of ERAD pathway;regulation of protein stability;response to endoplasmic reticulum stress;ubiquitin-dependent ERAD pathway","Hsp90 protein binding;Lys48-specific deubiquitinase activity;metal ion binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitin protein ligase binding","cytosol;endoplasmic reticulum membrane;integral component of membrane;nucleus",{"$nulls":3},10,10,0,"15.2","15.2",0,"145.65",0,"42.861",175660000,33,"0.187355",1,"-0.215102","-0.490301","sp|O94966|UBP19_HUMAN;tr|E7ESU0|E7ESU0_HUMAN","sp|O94966|UBP19_HUMAN;tr|E7ESU0|E7ESU0_HUMAN",701,"O94966","UBP19_HUMAN","Ubiquitin carboxyl-terminal hydrolase 19",null,"USP19"]
["25.8256","23.851","25.0586","26.0872","24.0965","25.1978",{"$nulls":3},"developmental growth;eukaryotic translation initiation factor 4F complex assembly;formation of translation preinitiation complex;regulation of translational initiation;sexual reproduction;translational initiation;viral process","cadherin binding;helicase activity;ribosomal small subunit binding;RNA binding;RNA strand annealing activity;RNA strand-exchange activity;translation factor activity, RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 4F complex;membrane;perinuclear region of cytoplasm;polysome",{"$nulls":3},10,10,10,"47.6","47.6","47.6","27.385",0,"252.33",5214500000,117,"0.0946151",1,"-0.215426","-0.264814","sp|Q15056|IF4H_HUMAN","sp|Q15056|IF4H_HUMAN",2550,"Q15056","IF4H_HUMAN","Eukaryotic translation initiation factor 4H","IF-4H","EIF4H"]
["25.4445","24.7908","24.9079","25.7231","25.0848","24.9834",{"$nulls":3},"calcium ion transport;cell differentiation;cellular calcium ion homeostasis;negative regulation of apoptotic process;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;regulation of apoptotic process;response to virus","calcium ion binding;microtubule binding;RNA binding","cytoplasm;cytosol;extracellular exosome;extracellular space;multivesicular body;nucleus",{"$nulls":3},7,7,7,"32.6","32.6","32.6","19.595",0,"95.052",2323300000,126,"0.28394",1,"-0.216071","-0.704336","sp|P13693|TCTP_HUMAN;tr|Q5W0H4|Q5W0H4_HUMAN;tr|A0A0B4J2C3|A0A0B4J2C3_HUMAN;tr|J3KPG2|J3KPG2_HUMAN;tr|E9PJF7|E9PJF7_HUMAN;sp|Q56UQ5|TPT1L_HUMAN;tr|H0YCX0|H0YCX0_HUMAN","sp|P13693|TCTP_HUMAN;tr|Q5W0H4|Q5W0H4_HUMAN;tr|A0A0B4J2C3|A0A0B4J2C3_HUMAN;tr|J3KPG2|J3KPG2_HUMAN;tr|E9PJF7|E9PJF7_HUMAN",1086,"P13693","TCTP_HUMAN","Translationally-controlled tumor protein","CTP","TPT1"]
["24.5498","22.9355","23.8189","24.6868","23.2884","23.9811",{"$nulls":3},"chaperone mediated protein folding requiring cofactor;negative regulation of establishment of protein localization to mitochondrion;negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;negative regulation of p38MAPK cascade;positive regulation of MHC class I biosynthetic process;positive regulation of NK T cell activation;positive regulation of protein tyrosine kinase activity;positive regulation of transcription from RNA polymerase II promoter;receptor-mediated endocytosis;regulation of cellular response to heat;response to unfolded protein","adenyl-nucleotide exchange factor activity;alpha-tubulin binding;ATP binding","cytoplasm;cytosol;endocytic vesicle lumen;extracellular exosome;extracellular region;microtubule;nucleoplasm;protein complex","Protein processing in endoplasmic reticulum",null,null,42,40,39,"68.8","66.2","64.6","96.864",0,"323.31",7810000000,299,"0.12936",1,"-0.217386","-0.352284","sp|Q92598|HS105_HUMAN;tr|A0A0A0MSM0|A0A0A0MSM0_HUMAN;tr|R4GN69|R4GN69_HUMAN;tr|Q5TBM3|Q5TBM3_HUMAN","sp|Q92598|HS105_HUMAN;tr|A0A0A0MSM0|A0A0A0MSM0_HUMAN",3685,"Q92598","HS105_HUMAN","Heat shock protein 105 kDa",null,"HSPH1"]
["20.9311","18.9138","20.3979","20.8352","19.6599","20.4",{"$nulls":3},"proteasome assembly;ubiquitin-dependent ERAD pathway","protein complex scaffold activity","centrosome;COPII-coated ER to Golgi transport vesicle;cytoplasmic vesicle;early endosome;endocytic vesicle;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;late endosome;membrane;multivesicular body;nucleus;proteasome complex",{"$nulls":3},44,44,44,"33.8","33.8","33.8","204.29",0,"309.96",1137400000,128,"0.113621",1,"-0.217409","-0.31317","sp|Q5VYK3|ECM29_HUMAN;tr|J3KN16|J3KN16_HUMAN;tr|R4GMY1|R4GMY1_HUMAN;tr|F6XAQ5|F6XAQ5_HUMAN;tr|R4GMY3|R4GMY3_HUMAN","sp|Q5VYK3|ECM29_HUMAN;tr|J3KN16|J3KN16_HUMAN",2907,"Q5VYK3","ECM29_HUMAN","Proteasome-associated protein ECM29 homolog","cm29","ECM29"]
["22.1842","21.1774","22.0114","22.8299","21.1042","22.0951",{"$nulls":3},"inflammatory response;positive regulation of translation;translation;translational initiation;transmembrane transport","ATP binding;ATPase activity;ribosome binding;RNA binding;translation activator activity;translation factor activity, RNA binding","cytoplasm;cytosol;membrane;nuclear envelope;nucleoplasm;polysomal ribosome;ribosome",{"$nulls":3},38,38,38,"55.6","55.6","55.6","95.925",0,"323.31",11598000000,515,"0.137211",1,"-0.218718","-0.371504","sp|Q8NE71|ABCF1_HUMAN;tr|H0YGW7|H0YGW7_HUMAN;tr|Q5STZ8|Q5STZ8_HUMAN;tr|A0A0G2JIC2|A0A0G2JIC2_HUMAN;tr|F5GYK6|F5GYK6_HUMAN","sp|Q8NE71|ABCF1_HUMAN;tr|H0YGW7|H0YGW7_HUMAN",3487,"Q8NE71","ABCF1_HUMAN","ATP-binding cassette sub-family F member 1",null,"ABCF1"]
["14.9171","14.6282","16.7027","16.2072","14.418","16.2812",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitin-specific protease activity","cytosol;Golgi apparatus",{"$nulls":3},3,3,3,"3.4","3.4","3.4","143.94",0,"8.8947",35669000,6,"0.0876147",1,"-0.219497","-0.246668","tr|K7EQL6|K7EQL6_HUMAN;sp|Q8NFA0|UBP32_HUMAN;tr|K7EKZ1|K7EKZ1_HUMAN;tr|K7EL53|K7EL53_HUMAN;tr|K7EII4|K7EII4_HUMAN","tr|K7EQL6|K7EQL6_HUMAN;sp|Q8NFA0|UBP32_HUMAN;tr|K7EKZ1|K7EKZ1_HUMAN",3501,"K7EQL6","K7EQL6_HUMAN",null,null,"USP32"]
["18.853","17.5319","17.2811","18.8481","17.5908","17.8911",{"$nulls":3},"activation of cysteine-type endopeptidase activity;activation of cysteine-type endopeptidase activity involved in apoptotic process;activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;apoptotic process;apoptotic signaling pathway;B cell activation;cell surface receptor signaling pathway;cellular response to mechanical stimulus;cellular response to organic cyclic compound;death-inducing signaling complex assembly;execution phase of apoptosis;extrinsic apoptotic signaling pathway;macrophage differentiation;natural killer cell activation;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of I-kappaB kinase/NF-kappaB signaling;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of macrophage differentiation;positive regulation of neuron death;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;positive regulation of proteolysis;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of necroptotic process;regulation of tumor necrosis factor-mediated signaling pathway;response to antibiotic;response to cobalt ion;response to cold;response to estradiol;response to ethanol;response to lipopolysaccharide;response to tumor necrosis factor;suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process;syncytiotrophoblast cell differentiation involved in labyrinthine layer development;T cell activation;toll-like receptor 3 signaling pathway;TRAIL-activated apoptotic signaling pathway;TRIF-dependent toll-like receptor signaling pathway","cysteine-type endopeptidase activity;cysteine-type endopeptidase activity involved in apoptotic process;cysteine-type endopeptidase activity involved in apoptotic signaling pathway;cysteine-type endopeptidase activity involved in execution phase of apoptosis;cysteine-type peptidase activity;death effector domain binding;death receptor binding;identical protein binding;peptidase activity;protein complex binding;scaffold protein binding;tumor necrosis factor receptor binding;ubiquitin protein ligase binding","CD95 death-inducing signaling complex;cell body;cytoskeleton;cytosol;death-inducing signaling complex;membrane raft;mitochondrial outer membrane;mitochondrion;neuron projection;nucleoplasm;ripoptosome","Alzheimer disease;Apoptosis;Apoptosis - multiple species;Chagas disease (American trypanosomiasis);C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Huntington disease;IL-17 signaling pathway;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Measles;Necroptosis;NOD-like receptor signaling pathway;Non-alcoholic fatty liver disease (NAFLD);p53 signaling pathway;Pathways in cancer;Platinum drug resistance;RIG-I-like receptor signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;Viral carcinogenesis;Viral myocarditis",null,null,6,6,6,"17.5","17.5","17.5","55.391",0,"9.8493",83458000,5,"0.131801",1,"-0.221277","-0.358279","sp|Q14790|CASP8_HUMAN;tr|E7ETB7|E7ETB7_HUMAN;tr|E7EQ06|E7EQ06_HUMAN;tr|A0A0A0MS31|A0A0A0MS31_HUMAN;tr|E7EQ01|E7EQ01_HUMAN;tr|E7EVN1|E7EVN1_HUMAN;tr|H7C0E2|H7C0E2_HUMAN;tr|H7BZM4|H7BZM4_HUMAN;tr|C9JB29|C9JB29_HUMAN","sp|Q14790|CASP8_HUMAN;tr|E7ETB7|E7ETB7_HUMAN;tr|E7EQ06|E7EQ06_HUMAN;tr|A0A0A0MS31|A0A0A0MS31_HUMAN;tr|E7EQ01|E7EQ01_HUMAN;tr|E7EVN1|E7EVN1_HUMAN;tr|H7C0E2|H7C0E2_HUMAN",2508,"Q14790","CASP8_HUMAN","Caspase-8","ASP-8","CASP8"]
["21.0862","19.8562","19.7227","21.5121","19.7886","20.0299",{"$nulls":3},"ceramide biosynthetic process;positive regulation of lipophagy;sphinganine biosynthetic process;sphingolipid biosynthetic process;sphingolipid metabolic process;sphingomyelin biosynthetic process;sphingosine biosynthetic process","pyridoxal phosphate binding;serine C-palmitoyltransferase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;serine C-palmitoyltransferase complex;SPOTS complex","Metabolic pathways;Sphingolipid metabolism;Sphingolipid signaling pathway",null,null,10,10,10,"27.3","27.3","27.3","52.743",0,"89.09",376870000,36,"0.11659",1,"-0.221802","-0.32061","sp|O15269|SPTC1_HUMAN","sp|O15269|SPTC1_HUMAN",357,"O15269","SPTC1_HUMAN","Serine palmitoyltransferase 1",null,"SPTLC1"]
["21.2864","19.2166","17.9895","20.7307","18.5317","19.8989",{"$nulls":3},"chromosome segregation;histone methylation;N-terminal peptidyl-alanine methylation;N-terminal peptidyl-alanine trimethylation;N-terminal peptidyl-glycine methylation;N-terminal peptidyl-proline dimethylation;N-terminal peptidyl-serine dimethylation;N-terminal peptidyl-serine trimethylation;spindle organization","histone methyltransferase activity;N-terminal protein N-methyltransferase activity;protein methyltransferase activity","cytoplasm;cytosol;nucleoplasm;nucleus",{"$nulls":3},7,7,4,"46.6","46.6","25.1","25.387",0,"33.949",110630000,22,"0.0672769",1,"-0.222913","-0.192824","sp|Q9BV86|NTM1A_HUMAN;tr|S4R3J7|S4R3J7_HUMAN;tr|S4R344|S4R344_HUMAN","sp|Q9BV86|NTM1A_HUMAN",4244,"Q9BV86","NTM1A_HUMAN","N-terminal Xaa-Pro-Lys N-methyltransferase 1",null,"NTMT1"]
["20.0747","18.1424","19.9767","20.5451","18.3289","19.99",{"$nulls":3},"nuclear export;protein transport;ribosome biogenesis","GTP binding;GTPase activity","Cajal body;cytosol;endoplasmic reticulum;membrane;nuclear body;nucleus","Ribosome biogenesis in eukaryotes",null,null,15,15,15,"28.7","28.7","28.7","75.225",0,"124.72",812030000,64,"0.0865805",1,"-0.223361","-0.243971","sp|Q9H089|LSG1_HUMAN;tr|F8WFC6|F8WFC6_HUMAN;tr|H7C2X7|H7C2X7_HUMAN","sp|Q9H089|LSG1_HUMAN",4380,"Q9H089","LSG1_HUMAN","Large subunit GTPase 1 homolog","Lsg1","LSG1"]
["24.7431","25.4475","25.726","25.2561","26.0309","25.3078",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of protein targeting to mitochondrion;regulation of autophagy of mitochondrion;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cell body;cytoplasmic ribonucleoprotein granule;cytosol;cytosolic large ribosomal subunit;dendrite;extracellular exosome;membrane","Ribosome",null,null,9,9,9,46,46,46,"15.747",0,"67.632",20851000000,206,"0.230259",1,"-0.226059","-0.587399","sp|P46779|RL28_HUMAN;tr|H0YKD8|H0YKD8_HUMAN;tr|H0YMF4|H0YMF4_HUMAN;tr|H0YLP6|H0YLP6_HUMAN","sp|P46779|RL28_HUMAN;tr|H0YKD8|H0YKD8_HUMAN;tr|H0YMF4|H0YMF4_HUMAN;tr|H0YLP6|H0YLP6_HUMAN",1599,"P46779","RL28_HUMAN","60S ribosomal protein L28",null,"RPL28"]
["18.5406","18.103","19.5418","19.1432","18.553","19.1714",{"$nulls":3},"cellular response to stimulus;hippocampus development;negative regulation of translational initiation in response to stress;oligodendrocyte development;response to glucose;response to heat;response to peptide hormone;translational initiation","guanyl-nucleotide exchange factor activity;nucleotidyltransferase activity;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex","Herpes simplex virus 1 infection;RNA transport",null,null,13,13,13,"33.2","33.2","33.2","50.24",0,"60.886",463400000,65,"0.184087",1,"-0.227443","-0.482749","sp|Q9NR50|EI2BG_HUMAN;tr|H0Y580|H0Y580_HUMAN;tr|A0A0D9SEN0|A0A0D9SEN0_HUMAN","sp|Q9NR50|EI2BG_HUMAN",4680,"Q9NR50","EI2BG_HUMAN","Translation initiation factor eIF-2B subunit gamma",null,"EIF2B3"]
["19.2943","18.9523","19.8339",20,"19.2538","19.5116",{"$nulls":3},"cell cycle arrest;cellular response to DNA damage stimulus;DNA damage response, detection of DNA damage;G1/S transition of mitotic cell cycle;global genome nucleotide-excision repair;hemopoiesis;in utero embryonic development;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;negative regulation of granulocyte differentiation;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;positive regulation of cell proliferation;positive regulation of G1/S transition of mitotic cell cycle;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of DNA damage checkpoint;regulation of nucleotide-excision repair;regulation of protein metabolic process;somatic stem cell population maintenance;transcription-coupled nucleotide-excision repair;viral process","ubiquitin protein ligase binding","Cul4A-RING E3 ubiquitin ligase complex;Cul4-RING E3 ubiquitin ligase complex;nucleoplasm","Human immunodeficiency virus 1 infection;Nucleotide excision repair;Ubiquitin mediated proteolysis",null,null,20,14,14,"31.2","23.2","23.2","87.679",0,"39.648",420270000,39,"0.271255",1,"-0.228336","-0.677097","sp|Q13619|CUL4A_HUMAN;tr|A0A0A0MR50|A0A0A0MR50_HUMAN;tr|A0A087WWN2|A0A087WWN2_HUMAN","sp|Q13619|CUL4A_HUMAN;tr|A0A0A0MR50|A0A0A0MR50_HUMAN",2395,"Q13619","CUL4A_HUMAN","Cullin-4A","UL-4A","CUL4A"]
["21.8675","21.54","22.3821","22.5678","21.4269","22.4916",{"$nulls":3},"central nervous system development;signal transduction;synaptic vesicle uncoating","cadherin binding;GTPase binding;identical protein binding;lipid binding;phosphatase binding","cell junction;cell projection;cytoplasm;early endosome membrane;podosome;synapse","Endocytosis",null,null,14,14,14,"48.4","48.4","48.4","41.489",0,"162.4",793550000,50,"0.20247",1,"-0.232206","-0.524933","sp|Q99961|SH3G1_HUMAN;tr|M0QYE0|M0QYE0_HUMAN;tr|M0R0I3|M0R0I3_HUMAN;sp|Q99962|SH3G2_HUMAN;tr|M0R2K6|M0R2K6_HUMAN","sp|Q99961|SH3G1_HUMAN;tr|M0QYE0|M0QYE0_HUMAN;tr|M0R0I3|M0R0I3_HUMAN",4122,"Q99961","SH3G1_HUMAN","Endophilin-A2",null,"SH3GL1"]
["23.0784","21.1805","22.1696","23.6647","21.0296","22.4431",{"$nulls":3},"innate immune response;negative regulation of cyclin-dependent protein serine/threonine kinase activity;protein import into nucleus;signal transduction;viral process","GTPase regulator activity;histone binding;protein transporter activity;Ran GTPase binding;SMAD binding;transporter activity","cytosol;membrane;nuclear pore;nucleoplasm",{"$nulls":3},27,27,27,"32.2","32.2","32.2","119.52",0,"247.63",2279100000,124,"0.0896273",1,"-0.23631","-0.251904","sp|O95373|IPO7_HUMAN;tr|E9PLJ0|E9PLJ0_HUMAN;tr|E9PLB2|E9PLB2_HUMAN","sp|O95373|IPO7_HUMAN",747,"O95373","IPO7_HUMAN","Importin-7","mp7","IPO7"]
["17.1053","15.9501","15.7566","17.4682","15.7408","16.3125",{"$nulls":4},"zinc ion binding","nucleoplasm",{"$nulls":3},3,3,2,"10.1","10.1","7.3","50.403",0,"14.58",87894000,8,"0.131841",1,"-0.23648","-0.358377","tr|B3KPJ4|B3KPJ4_HUMAN;tr|A0A0A0MSI2|A0A0A0MSI2_HUMAN;sp|Q8IXK0|PHC2_HUMAN;tr|H7C528|H7C528_HUMAN","tr|B3KPJ4|B3KPJ4_HUMAN;tr|A0A0A0MSI2|A0A0A0MSI2_HUMAN;sp|Q8IXK0|PHC2_HUMAN",3321,"B3KPJ4","B3KPJ4_HUMAN",null,null,"PHC2"]
["16.9032","17.4768","17.1729","17.9874","17.2233","17.0603",{"$nulls":3},"snRNA processing;snRNA transcription from RNA polymerase II promoter",null,"cytosol;integrator complex;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"9.3","9.3","9.3","73.814",0,"19.863",51781000,7,"0.293445",1,"-0.239356","-0.724605","sp|Q9NV88|INT9_HUMAN;tr|H0YBK3|H0YBK3_HUMAN;tr|G3XAN1|G3XAN1_HUMAN;tr|E5RJ88|E5RJ88_HUMAN;tr|E5RK47|E5RK47_HUMAN;tr|H0YBH8|H0YBH8_HUMAN;tr|E5RG70|E5RG70_HUMAN","sp|Q9NV88|INT9_HUMAN;tr|H0YBK3|H0YBK3_HUMAN;tr|G3XAN1|G3XAN1_HUMAN",4752,"Q9NV88","INT9_HUMAN","Integrator complex subunit 9","nt9","INTS9"]
["19.5288","19.1366","16.81","18.9236","18.8604","18.4163",{"$nulls":3},"hematopoietic progenitor cell differentiation",{"$nulls":5},3,3,3,"13.2","13.2","13.2","37.49","0.0024914","2.9928",86195000,4,"0.100481",1,"-0.241636","-0.279877","sp|Q8N999|CL029_HUMAN","sp|Q8N999|CL029_HUMAN",3437,"Q8N999","CL029_HUMAN","Uncharacterized protein C12orf29",null,"C12orf29"]
["14.4492","16.3646","15.7559","15.7825","15.3212","16.2122",{"$nulls":3},"ATP-dependent chromatin remodeling;brain development;chromatin remodeling;covalent chromatin modification;neuron differentiation;positive regulation of transcription, DNA-templated;transcription, DNA-templated","annealing helicase activity;ATP binding;ATPase activity;DNA binding;helicase activity;nucleosome binding;transcription factor binding","CERF complex;intracellular membrane-bounded organelle;nucleoplasm;nucleus;NURF complex",{"$nulls":3},22,11,11,"21.2","12.1","12.1","122.6",0,"24.311",193310000,26,"0.149227",1,"-0.248699","-0.400574","sp|P28370|SMCA1_HUMAN;tr|A0A0A0MRP6|A0A0A0MRP6_HUMAN;tr|B7ZLQ5|B7ZLQ5_HUMAN","sp|P28370|SMCA1_HUMAN;tr|A0A0A0MRP6|A0A0A0MRP6_HUMAN;tr|B7ZLQ5|B7ZLQ5_HUMAN",1342,"P28370","SMCA1_HUMAN","Probable global transcription activator SNF2L1",null,"SMARCA1"]
["21.3608","18.6963","20.5331","22.0488","18.8758","20.4143",{"$nulls":4},"RNA binding",{"$nulls":4},5,1,1,31,"9.4","9.4","32.035",0,"17.69",153990000,10,"0.0724257",1,"-0.249591","-0.206621","tr|F8VRH0|F8VRH0_HUMAN","tr|F8VRH0|F8VRH0_HUMAN",5534,"F8VRH0","F8VRH0_HUMAN",null,null,"PCBP2"]
["20.0816","17.5311","20.0178","20.8234","17.6255","19.9399",{"$nulls":3},"tRNA processing","protein kinase binding","cytosol;EKC/KEOPS complex;nucleus",{"$nulls":3},3,3,3,"30.9","30.9","30.9","19.661",0,"29.607",57650000,11,"0.0695549",1,"-0.252763","-0.198942","sp|Q9Y3C4|TPRKB_HUMAN","sp|Q9Y3C4|TPRKB_HUMAN",5288,"Q9Y3C4","TPRKB_HUMAN","EKC/KEOPS complex subunit TPRKB",null,"TPRKB"]
["18.2365","16.7816","18.2891","18.9156","16.6722","18.4835",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;positive regulation of I-kappaB kinase/NF-kappaB signaling;transcription, DNA-templated","cadherin binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;signal transducer activity;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytosol;extracellular exosome;fibrillar center;membrane;microtubule organizing center;nucleus;plasma membrane",{"$nulls":3},9,9,9,"14.1","14.1","14.1","104.06",0,"27.763",155160000,20,"0.10876",1,"-0.254675","-0.300923","sp|Q6P1N0|C2D1A_HUMAN;tr|K7EJY5|K7EJY5_HUMAN;tr|K7EMP1|K7EMP1_HUMAN","sp|Q6P1N0|C2D1A_HUMAN",3000,"Q6P1N0","C2D1A_HUMAN","Coiled-coil and C2 domain-containing protein 1A",null,"CC2D1A"]
["19.1686","18.4229","16.5832","19.5091","18.5213","16.9112",{"$nulls":3},"formation of translation preinitiation complex;intracellular protein transport;IRES-dependent viral translational initiation;ribosome disassembly","receptor activity;translation initiation factor activity","cytoplasm;cytosol;nuclear body",{"$nulls":3},6,6,6,"16.8","16.8","16.8","64.706",0,"27.465",175470000,26,"0.083914",1,"-0.255634","-0.236998","sp|P41214|EIF2D_HUMAN;tr|Q5SY38|Q5SY38_HUMAN;tr|A0A087X1L6|A0A087X1L6_HUMAN","sp|P41214|EIF2D_HUMAN;tr|Q5SY38|Q5SY38_HUMAN",1531,"P41214","EIF2D_HUMAN","Eukaryotic translation initiation factor 2D","IF2d","EIF2D"]
["14.99","16.4101","16.822","16.2556","15.9633","16.7717",{"$nulls":3},"actin cytoskeleton organization;activation of JUN kinase activity;activation of MAPK activity;activation of MAPKK activity;activation of protein kinase activity;apoptotic process;axonogenesis;cell migration;cellular response to DNA damage stimulus;dendrite arborization;focal adhesion assembly;mitotic G2 DNA damage checkpoint;nervous system development;positive regulation of dendrite morphogenesis;positive regulation of JNK cascade;positive regulation of neuron projection development;positive regulation of protein autophosphorylation;positive regulation of stress-activated MAPK cascade;protein autophosphorylation;protein targeting to membrane;regulation of actin cytoskeleton organization;regulation of apoptotic process;regulation of cell growth;regulation of cell shape;regulation of mitotic cell cycle;response to stress;stress-activated MAPK cascade","ATP binding;MAP kinase kinase kinase activity;mitogen-activated protein kinase kinase binding;neuropilin binding;protein serine/threonine kinase activity","actin cytoskeleton;axon;axonal growth cone;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;dendritic growth cone;integral component of membrane;intracellular;neuron projection;nucleolus;nucleus;receptor complex","MAPK signaling pathway",null,null,19,16,16,"17.5","15.6","15.6","138.25",0,"66.204",674950000,71,"0.15932",1,"-0.256143","-0.424683","sp|Q9UL54|TAOK2_HUMAN;REV__tr|U3KPR5|U3KPR5_HUMAN;REV__sp|P05412|JUN_HUMAN;REV__sp|P17535|JUND_HUMAN;REV__sp|P17275|JUNB_HUMAN","sp|Q9UL54|TAOK2_HUMAN",5111,"Q9UL54","TAOK2_HUMAN","Serine/threonine-protein kinase TAO2",null,"TAOK2"]
["20.3279","18.1506","18.6876","20.6954","18.3664","18.8769",{"$nulls":3},"negative regulation of mitochondrial membrane potential;neutrophil degranulation;positive regulation of mitochondrial membrane permeability;positive regulation of necrotic cell death",null,"azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;mitochondrion",{"$nulls":3},2,2,2,"13.2","13.2","13.2","22.875",0,"7.2684",61805000,4,"0.0955604",1,"-0.257513","-0.26725","sp|Q9Y5Z4|HEBP2_HUMAN;tr|Q5THN1|Q5THN1_HUMAN","sp|Q9Y5Z4|HEBP2_HUMAN;tr|Q5THN1|Q5THN1_HUMAN",5378,"Q9Y5Z4","HEBP2_HUMAN","Heme-binding protein 2",null,"HEBP2"]
["20.1461","19.223","19.497","20.6891","19.0033","19.9518",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;insulin receptor signaling pathway;plasma membrane organization;positive regulation of actin cytoskeleton reorganization;positive regulation of actin filament polymerization;regulation of insulin receptor signaling pathway;response to bacterium","actin binding;cadherin binding involved in cell-cell adhesion;proline-rich region binding","cell-cell adherens junction;cytoskeleton;cytosol;extracellular exosome;nucleoplasm;plasma membrane",{"$nulls":3},12,12,12,"31.9","31.9","31.9","56.882",0,"69.136",346070000,38,"0.175841",1,"-0.25935","-0.463579","sp|Q9UHR4|BI2L1_HUMAN","sp|Q9UHR4|BI2L1_HUMAN",5031,"Q9UHR4","BI2L1_HUMAN","Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1","AI1-associated protein 2-like protein 1","BAIAP2L1"]
["19.1516",1,"18.919","20.8718",1,"17.9818",{"$nulls":3},"cellular response to interferon-gamma;intracellular protein transport;long-term synaptic potentiation;organelle fusion;positive regulation of catalytic activity;positive regulation of cell adhesion;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of chemotaxis;positive regulation of eosinophil degranulation;positive regulation of immunoglobulin secretion;positive regulation of insulin secretion involved in cellular response to glucose stimulus;positive regulation of protein localization to cell surface;positive regulation of protein localization to plasma membrane;post-Golgi vesicle-mediated transport;regulation of exocytosis;regulation of extrinsic apoptotic signaling pathway via death domain receptors;response to hydroperoxide;SNARE complex assembly;synaptic vesicle fusion to presynaptic active zone membrane;vesicle docking;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane","SNAP receptor activity;SNARE binding;sphingomyelin phosphodiesterase activator activity","basolateral plasma membrane;cell surface;cytosol;dendritic spine;endosome;extracellular exosome;extracellular space;integral component of membrane;intracellular;lamellipodium;lateral loop;membrane;myelin sheath adaxonal region;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;SNARE complex;somatodendritic compartment;specific granule;storage vacuole;synapse;synaptic vesicle;trans-Golgi network;vacuole","SNARE interactions in vesicular transport;Vasopressin-regulated water reabsorption",null,null,4,4,4,"13.1","13.1","13.1","34.18",0,"20.332",60904000,8,"0.00995637",1,"-0.261005","-0.0302252","sp|Q12846|STX4_HUMAN;tr|C9JFM5|C9JFM5_HUMAN","sp|Q12846|STX4_HUMAN;tr|C9JFM5|C9JFM5_HUMAN",2267,"Q12846","STX4_HUMAN","Syntaxin-4",null,"STX4"]
["18.6267","18.9735","19.335","18.9692","19.2387","19.5167",{"$nulls":3},"axon target recognition;cellular response to interferon-gamma;developmental process involved in reproduction;glutamate secretion;long term synaptic depression;negative regulation of neuron apoptotic process;negative regulation of protein complex assembly;negative regulation of synaptic transmission, GABAergic;neuromuscular synaptic transmission;neurotransmitter secretion;platelet aggregation;platelet degranulation;positive regulation of calcium ion-dependent exocytosis;positive regulation of glutamate secretion, neurotransmission;positive regulation of mast cell degranulation;positive regulation of vesicle docking;presynaptic dense core vesicle exocytosis;protein localization to plasma membrane;protein stabilization;protein transport;regulation of SNARE complex assembly;regulation of synaptic vesicle fusion to presynaptic active zone membrane;regulation of synaptic vesicle priming;response to estradiol;synaptic vesicle maturation;vesicle docking involved in exocytosis","identical protein binding;phospholipase binding;protein domain specific binding;protein kinase binding;protein N-terminus binding;RNA binding;SNARE binding;syntaxin binding;syntaxin-1 binding","cytoplasm;cytoskeleton;cytosol;extracellular exosome;mitochondrion;myelin sheath;nucleoplasm;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;platelet alpha granule;postsynapse;presynaptic active zone membrane;protein complex;terminal bouton","Synaptic vesicle cycle",null,null,10,10,10,"26.8","26.8","26.8","67.568",0,"40.278",202600000,20,"0.436353",1,"-0.263163","-1.01824","sp|P61764|STXB1_HUMAN;tr|A0A096LP52|A0A096LP52_HUMAN","sp|P61764|STXB1_HUMAN",1938,"P61764","STXB1_HUMAN","Syntaxin-binding protein 1",null,"STXBP1"]
["20.4863","16.3768","16.619","20.2183","16.8629","17.1946",{"$nulls":3},"autophagy of peroxisome;cellular response to glucose starvation;late endosome to vacuole transport;macroautophagy;phosphatidylinositol biosynthetic process;positive regulation of phosphatidylinositol 3-kinase activity;protein phosphorylation;protein targeting to vacuole;receptor catabolic process;regulation of cytokinesis;toll-like receptor 9 signaling pathway","1-phosphatidylinositol-3-kinase activity;ATP binding;protein kinase activity;protein serine/threonine kinase activity","autophagosome;axoneme;cytosol;intracellular membrane-bounded organelle;late endosome;membrane;microtubule cytoskeleton;nuclear pore;nucleus-vacuole junction;phagocytic vesicle membrane;phosphatidylinositol 3-kinase complex, class III;phosphatidylinositol 3-kinase complex, class III, type I;phosphatidylinositol 3-kinase complex, class III, type II","Apelin signaling pathway;Autophagy - animal;Autophagy - other",null,null,8,8,8,"9.1","9.1","9.1","153.1",0,"20.387",250110000,13,"0.0534053",1,"-0.264586","-0.155052","sp|Q99570|PI3R4_HUMAN;tr|D6RJ98|D6RJ98_HUMAN","sp|Q99570|PI3R4_HUMAN",4080,"Q99570","PI3R4_HUMAN","Phosphoinositide 3-kinase regulatory subunit 4","I3-kinase regulatory subunit 4","PIK3R4"]
["22.7058","21.5533","22.3871","22.7907","22.1874","22.4692",{"$nulls":3},"intralumenal vesicle formation;membrane invagination;negative regulation of early endosome to late endosome transport;negative regulation of phagocytosis;negative regulation of protein catabolic process;negative regulation of protein transport;negative regulation of viral entry into host cell;positive regulation of neuron projection development;protein deubiquitination;protein to membrane docking;protein transport;regulation of Wnt signaling pathway;response to bacterium;Wnt signaling pathway","phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-3-phosphate binding;phosphatidylinositol-4-phosphate binding;phosphatidylinositol-5-phosphate binding;protein phosphatase binding","clathrin-coated vesicle;cytoplasm;cytosol;early endosome;early endosome membrane;early phagosome;endosome membrane;extracellular exosome;extrinsic component of membrane","Endocytosis",null,null,9,7,7,"59.9",50,50,"18.762",0,"73.484",571710000,25,"0.278704",1,"-0.267047","-0.69312","sp|O60493|SNX3_HUMAN","sp|O60493|SNX3_HUMAN",497,"O60493","SNX3_HUMAN","Sorting nexin-3",null,"SNX3"]
["23.2959","21.7954","22.8704","23.5922","22.0557","23.116",{"$nulls":3},"axon guidance;brain development;cytoskeleton organization;endocytosis;nervous system development;nucleobase-containing compound metabolic process;regulation of axon extension;signal transduction","dihydropyrimidinase activity;identical protein binding;microtubule binding","cytoskeleton;cytosol;extracellular exosome;plasma membrane","Axon guidance",null,null,20,20,16,"57.7","57.7","47.7","62.293",0,"323.31",2431400000,156,"0.1573",1,"-0.267392","-0.41988","sp|Q16555|DPYL2_HUMAN;tr|E5RFU4|E5RFU4_HUMAN","sp|Q16555|DPYL2_HUMAN",2673,"Q16555","DPYL2_HUMAN","Dihydropyrimidinase-related protein 2","RP-2","DPYSL2"]
["19.3817","19.318","19.9245","19.6816","19.4908","20.2541",{"$nulls":3},"adult locomotory behavior;mRNA destabilization;positive regulation of gene silencing by miRNA;positive regulation of RIG-I signaling pathway;posttranscriptional gene silencing;posttranscriptional regulation of gene expression;production of miRNAs involved in gene silencing by miRNA;regulation of cell cycle;regulation of chromosome segregation;regulation of gene silencing by miRNA;regulation of mRNA stability;spermatogenesis;stem cell differentiation","miRNA binding;mRNA 3'-UTR binding;RNA binding","cytoplasmic stress granule;cytosol;nuclear speck;nucleoplasm;nucleus;P-body",{"$nulls":3},10,10,1,"10.4","10.4","1.3","126.47",0,"31.367",506700000,30,"0.374552",1,"-0.267461","-0.893411","sp|Q14671|PUM1_HUMAN;tr|H0YEH2|H0YEH2_HUMAN;tr|E9PR38|E9PR38_HUMAN;tr|H0YDC5|H0YDC5_HUMAN","sp|Q14671|PUM1_HUMAN;tr|H0YEH2|H0YEH2_HUMAN;tr|E9PR38|E9PR38_HUMAN",2488,"Q14671","PUM1_HUMAN","Pumilio homolog 1 {ECO:0000305}","sPUM;umilio-1","PUM1"]
["17.9532","16.9099","18.312","19.4087","16.509","18.0667",{"$nulls":9},4,4,4,"8.1","8.1","8.1","67.255",0,"11.742",59095000,13,"0.103572",1,"-0.269767","-0.287764","tr|A0A0D9SEU5|A0A0D9SEU5_HUMAN;sp|Q6VN20|RBP10_HUMAN;tr|R4GMX8|R4GMX8_HUMAN;tr|R4GMX7|R4GMX7_HUMAN;tr|R4GNA3|R4GNA3_HUMAN;tr|R4GN91|R4GN91_HUMAN","tr|A0A0D9SEU5|A0A0D9SEU5_HUMAN;sp|Q6VN20|RBP10_HUMAN;tr|R4GMX8|R4GMX8_HUMAN;tr|R4GMX7|R4GMX7_HUMAN;tr|R4GNA3|R4GNA3_HUMAN;tr|R4GN91|R4GN91_HUMAN",3066,"A0A0D9SEU5","A0A0D9SEU5_HUMAN",null,null,"RANBP10"]
["20.2891","19.6","20.0859","20.4646","19.6598","20.6691",{"$nulls":3},"cellular response to amino acid stimulus;covalent chromatin modification;DNA methylation;DNA methylation involved in embryo development;gene silencing;maintenance of DNA methylation;negative regulation of gene expression, epigenetic;negative regulation of histone H3-K9 methylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of gene expression;positive regulation of histone H3-K4 methylation;positive regulation of methylation-dependent chromatin silencing;Ras protein signal transduction;regulation of cell proliferation;transcription, DNA-templated","DNA (cytosine-5-)-methyltransferase activity;DNA binding;DNA-methyltransferase activity;methyl-CpG binding;promoter-specific chromatin binding;RNA binding;zinc ion binding","nucleoplasm;nucleus;pericentric heterochromatin;replication fork","Cysteine and methionine metabolism;Metabolic pathways;MicroRNAs in cancer",null,null,29,29,29,"22.2","22.2","22.2","183.16",0,"111.54",993660000,77,"0.299776",1,"-0.272865","-0.738041","sp|P26358|DNMT1_HUMAN;tr|K7ENW7|K7ENW7_HUMAN;tr|K7EJL0|K7EJL0_HUMAN;tr|K7EMU8|K7EMU8_HUMAN;tr|K7EIZ6|K7EIZ6_HUMAN;tr|K7EP77|K7EP77_HUMAN;tr|K7ENQ6|K7ENQ6_HUMAN","sp|P26358|DNMT1_HUMAN",1304,"P26358","DNMT1_HUMAN","DNA (cytosine-5)-methyltransferase 1","nmt1","DNMT1"]
[1,"16.7321","18.1161","17.1211",1,"18.5489",{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},5,5,5,"30.4","30.4","30.4","31.664",0,"30.646",176030000,19,"0.0114983",1,"-0.273923","-0.0348466","tr|H7C1M5|H7C1M5_HUMAN;sp|Q9H147|TDIF1_HUMAN;tr|H0Y501|H0Y501_HUMAN;tr|H7C1J2|H7C1J2_HUMAN;tr|F2Z2A4|F2Z2A4_HUMAN","tr|H7C1M5|H7C1M5_HUMAN;sp|Q9H147|TDIF1_HUMAN",4407,"H7C1M5","H7C1M5_HUMAN",null,null,"DNTTIP1"]
["19.6245","18.5524","19.6307","20.1711","18.668","19.7923",{"$nulls":3},"negative regulation of translation","identical protein binding;mRNA binding;protein heterodimerization activity;protein homodimerization activity;RNA binding","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;membrane;nucleus;polysome","RNA transport",null,null,11,9,8,"25.1","22.7","19.9","74.222",0,"30.053",300350000,25,"0.18139",1,"-0.274616","-0.476497","sp|P51116|FXR2_HUMAN;tr|I3L1Z2|I3L1Z2_HUMAN","sp|P51116|FXR2_HUMAN",1729,"P51116","FXR2_HUMAN","Fragile X mental retardation syndrome-related protein 2",null,"FXR2"]
["22.5551","19.6985","16.8027","21.3522","18.4417","20.1042",{"$nulls":3},"cristae formation",null,"cytosol;MICOS complex;mitochondrion",{"$nulls":3},4,4,4,"24.2","24.2","24.2","20.08",0,"11.561",138110000,14,"0.0518199",1,"-0.280605","-0.150677","tr|H7C1U8|H7C1U8_HUMAN;sp|Q9BUR5|MIC26_HUMAN;tr|A0A0J9YWW6|A0A0J9YWW6_HUMAN;tr|G3V1B6|G3V1B6_HUMAN","tr|H7C1U8|H7C1U8_HUMAN;sp|Q9BUR5|MIC26_HUMAN;tr|A0A0J9YWW6|A0A0J9YWW6_HUMAN;tr|G3V1B6|G3V1B6_HUMAN",4235,"H7C1U8","H7C1U8_HUMAN","MICOS complex subunit {ECO:0000256|RuleBase:RU363021}",null,"APOO"]
["22.392","21.1756","22.0397","22.6749","21.584","22.1932",{"$nulls":3},"cell division;DNA-dependent DNA replication;sister chromatid cohesion","chromatin binding","cytosol;nuclear chromatin;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},16,16,16,"35.5","35.5","35.5","72.979",0,"209.19",1143400000,64,"0.230026",1,"-0.281585","-0.586881","sp|Q9BTE3|MCMBP_HUMAN","sp|Q9BTE3|MCMBP_HUMAN",4205,"Q9BTE3","MCMBP_HUMAN","Mini-chromosome maintenance complex-binding protein","CM-binding protein;CM-BP","MCMBP"]
["16.3248","16.3898","16.5683","16.59","16.5515","16.9932",{"$nulls":3},"cytoplasmic mRNA processing body assembly;deadenylation-dependent decapping of nuclear-transcribed mRNA;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay","poly(G) binding;poly(U) RNA binding;RNA binding","cytoplasmic ribonucleoprotein granule;cytosol;nuclear speck;P-body;PML body","RNA degradation",null,null,3,3,3,"4.8","4.8","4.8","86.849","0.0030251","2.7558",63727000,3,"0.828332",1,"-0.283978","-1.78693","sp|Q86TB9|PATL1_HUMAN","sp|Q86TB9|PATL1_HUMAN",3206,"Q86TB9","PATL1_HUMAN","Protein PAT1 homolog 1",null,"PATL1"]
["22.4351","21.508","22.3708","22.8836","21.6894","22.5929",{"$nulls":3},"acrosome assembly;actin cytoskeleton organization;adult locomotory behavior;ameboidal-type cell migration;auditory receptor cell development;brain morphogenesis;cerebral cortex development;cerebral cortex neuron differentiation;chemical synaptic transmission;ciliary basal body-plasma membrane docking;cochlea development;corpus callosum morphogenesis;cortical microtubule organization;establishment of centrosome localization;establishment of mitotic spindle orientation;establishment of planar polarity of embryonic epithelium;G2/M transition of mitotic cell cycle;germ cell development;hippocampus development;layer formation in cerebral cortex;learning or memory;lipid catabolic process;maintenance of centrosome location;microtubule cytoskeleton organization;microtubule cytoskeleton organization involved in establishment of planar polarity;microtubule organizing center organization;microtubule-based process;negative regulation of JNK cascade;negative regulation of neuron projection development;neuroblast proliferation;neuromuscular process controlling balance;neuron migration;nuclear envelope disassembly;nuclear migration;osteoclast development;platelet activating factor metabolic process;positive regulation of axon extension;positive regulation of cytokine-mediated signaling pathway;positive regulation of dendritic spine morphogenesis;positive regulation of embryonic development;positive regulation of mitotic cell cycle;protein secretion;regulation of G2/M transition of mitotic cell cycle;regulation of GTPase activity;regulation of microtubule cytoskeleton organization;regulation of microtubule motor activity;retrograde axonal transport;sister chromatid cohesion;stem cell division;transmission of nerve impulse;vesicle transport along microtubule","dynactin binding;dynein complex binding;dynein intermediate chain binding;heparin binding;microtubule binding;phospholipase A2 activity;phospholipase binding;phosphoprotein binding;protein homodimerization activity","astral microtubule;axon cytoplasm;cell cortex;cell leading edge;central region of growth cone;centrosome;cytosol;extracellular exosome;kinesin complex;kinetochore;microtubule associated complex;motile cilium;neuronal cell body;nuclear envelope;nuclear membrane;perinuclear region of cytoplasm;stereocilium","Ether lipid metabolism;Metabolic pathways",null,null,10,10,10,"27.1","27.1","27.1","46.637",0,"59.439",1226300000,59,"0.239281",1,"-0.283981","-0.607375","sp|P43034|LIS1_HUMAN;tr|I3L495|I3L495_HUMAN;tr|I3L3N5|I3L3N5_HUMAN","sp|P43034|LIS1_HUMAN",1565,"P43034","LIS1_HUMAN","Platelet-activating factor acetylhydrolase IB subunit alpha {ECO:0000255|HAMAP-Rule:MF_03141}",null,"PAFAH1B1"]
["17.4776","18.1729","19.0874","19.0229","18.0082","18.5612",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;intra-Golgi vesicle-mediated transport;protein transport",null,"Golgi apparatus;Golgi membrane;Golgi transport complex;trans-Golgi network membrane",{"$nulls":3},11,11,11,"14.9","14.9","14.9","108.98",0,"32.918",178520000,17,"0.199001",1,"-0.284762","-0.517028","sp|Q8WTW3|COG1_HUMAN;tr|A0A087WVI0|A0A087WVI0_HUMAN;tr|E9PBL8|E9PBL8_HUMAN;tr|J3KSY3|J3KSY3_HUMAN;tr|J3QKY9|J3QKY9_HUMAN;tr|J3QLT5|J3QLT5_HUMAN","sp|Q8WTW3|COG1_HUMAN;tr|A0A087WVI0|A0A087WVI0_HUMAN;tr|E9PBL8|E9PBL8_HUMAN",3592,"Q8WTW3","COG1_HUMAN","Conserved oligomeric Golgi complex subunit 1","OG complex subunit 1","COG1"]
["19.1044","18.5946","18.6375","19.9475","17.951","19.2944",{"$nulls":3},"actin cytoskeleton reorganization;AV node cell to bundle of His cell communication;AV node cell-bundle of His cell adhesion involved in cell communication;cardiac muscle fiber development;cell-cell junction organization;defense response to virus;epithelial structure maintenance;gamma-delta T cell activation;germ cell migration;heart development;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;homotypic cell-cell adhesion;leukocyte migration;mitochondrion organization;neutrophil chemotaxis;regulation of AV node cell action potential;regulation of immune response;transepithelial transport","beta-catenin binding;cell adhesion molecule binding;cell adhesive protein binding involved in AV node cell-bundle of His cell communication;connexin binding;identical protein binding;integrin binding;PDZ domain binding;receptor binding;virus receptor activity","acrosomal vesicle;adherens junction;apicolateral plasma membrane;basolateral plasma membrane;bicellular tight junction;cell body;cell junction;cell-cell adherens junction;cell-cell junction;cytoplasm;extracellular region;extracellular space;filopodium;growth cone;integral component of plasma membrane;intercalated disc;membrane raft;neuromuscular junction;neuron projection;nucleoplasm;plasma membrane;protein complex","Viral myocarditis",null,null,6,6,6,"18.4","18.4","18.4","40.029",0,"15.919",185580000,14,"0.177721",1,"-0.285442","-0.467965","sp|P78310|CXAR_HUMAN","sp|P78310|CXAR_HUMAN",2050,"P78310","CXAR_HUMAN","Coxsackievirus and adenovirus receptor","AR;CAR","CXADR"]
["19.3458","17.8436","19.1677","19.8135","17.5274","19.88",{"$nulls":3},"covalent chromatin modification;regulation of transcription, DNA-templated;transcription, DNA-templated",null,"nuclear speck",{"$nulls":3},11,9,9,"37.6","30.5","30.5","40.028",0,"25.219",225780000,32,"0.115351",1,"-0.287973","-0.317508","tr|B3KTM8|B3KTM8_HUMAN;sp|Q9UBU8|MO4L1_HUMAN;tr|H0YLJ3|H0YLJ3_HUMAN;tr|H0YMJ0|H0YMJ0_HUMAN;tr|H0YM21|H0YM21_HUMAN;tr|H0YLV1|H0YLV1_HUMAN;tr|H0YMT8|H0YMT8_HUMAN;tr|H0YNE0|H0YNE0_HUMAN;tr|H0YNX3|H0YNX3_HUMAN;tr|H0YNI8|H0YNI8_HUMAN","tr|B3KTM8|B3KTM8_HUMAN;sp|Q9UBU8|MO4L1_HUMAN;tr|H0YLJ3|H0YLJ3_HUMAN;tr|H0YMJ0|H0YMJ0_HUMAN;tr|H0YM21|H0YM21_HUMAN;tr|H0YLV1|H0YLV1_HUMAN;tr|H0YMT8|H0YMT8_HUMAN",5477,"B3KTM8","B3KTM8_HUMAN",null,null,"MORF4L1"]
["23.2175","21.8629","22.9913","23.6935","22.1895","23.0605",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;protein methylation;regulation of translational termination;translational termination","ribosome binding;RNA binding;sequence-specific mRNA binding;translation release factor activity;translation termination factor activity","cytoplasm;cytosol","mRNA surveillance pathway",null,null,19,19,19,"53.8","53.8","53.8","49.03",0,"195.66",2305200000,111,"0.183163",1,"-0.290599","-0.480609","sp|P62495|ERF1_HUMAN;tr|B7Z7P8|B7Z7P8_HUMAN;tr|I3L492|I3L492_HUMAN;tr|D6RJE8|D6RJE8_HUMAN;tr|D6RCB3|D6RCB3_HUMAN","sp|P62495|ERF1_HUMAN;tr|B7Z7P8|B7Z7P8_HUMAN",1983,"P62495","ERF1_HUMAN","Eukaryotic peptide chain release factor subunit 1","RF1;ukaryotic release factor 1","ETF1"]
["19.4703","16.1462","19.9493","19.5904","16.7428","20.1125",{"$nulls":3},"box H/ACA snoRNP assembly;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;positive regulation of telomere maintenance via telomere lengthening;ribosome biogenesis;RNA stabilization;snoRNA guided rRNA pseudouridine synthesis;telomerase holoenzyme complex assembly;telomerase RNA stabilization","RNA binding;telomerase RNA binding","cytoplasm;nucleus;small nucleolar ribonucleoprotein complex",{"$nulls":3},4,4,4,"13.4","13.4","13.4","53.716",0,"18.679",157260000,27,"0.0641914",1,"-0.293268","-0.184499","sp|Q96HR8|NAF1_HUMAN;tr|D6RIB3|D6RIB3_HUMAN","sp|Q96HR8|NAF1_HUMAN",3914,"Q96HR8","NAF1_HUMAN","H/ACA ribonucleoprotein complex non-core subunit NAF1","NAF1","NAF1"]
["15.9627","16.6151",1,"17.383","16.0817",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},4,4,4,"9.9","9.9","9.9","60.833",0,"6.4667",65131000,8,"0.0133444",1,"-0.295616","-0.0403594","tr|I3L072|I3L072_HUMAN;sp|Q9BSJ5|CQ080_HUMAN;tr|J3KT60|J3KT60_HUMAN;tr|J3KTJ7|J3KTJ7_HUMAN","tr|I3L072|I3L072_HUMAN;sp|Q9BSJ5|CQ080_HUMAN",4186,"I3L072","I3L072_HUMAN",null,null,"C17orf80"]
["26.5092","22.799","25.3231","26.0673","23.9142","25.5597",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},5,4,4,"54.5","47.9","47.9","14.478",0,"314.77",12103000000,141,"0.0844368",1,"-0.303312","-0.238367","tr|C9JYQ9|C9JYQ9_HUMAN;sp|Q6P5R6|RL22L_HUMAN;tr|H0Y8C2|H0Y8C2_HUMAN","tr|C9JYQ9|C9JYQ9_HUMAN;sp|Q6P5R6|RL22L_HUMAN;tr|H0Y8C2|H0Y8C2_HUMAN",3017,"C9JYQ9","C9JYQ9_HUMAN",null,null,"RPL22L1"]
["18.5512","16.9662","16.091","18.7193","16.8914","16.9089",{"$nulls":3},"COPII vesicle coating;protein transport",null,"endoplasmic reticulum;Golgi membrane",{"$nulls":3},15,15,15,"11.4","11.4","11.4","249.48",0,"56.115",174260000,23,"0.11741",1,"-0.303733","-0.322658","tr|F1T0I1|F1T0I1_HUMAN;tr|J3KNL6|J3KNL6_HUMAN;sp|O15027|SC16A_HUMAN;tr|X6RGP5|X6RGP5_HUMAN;tr|A0A0C4DH09|A0A0C4DH09_HUMAN;tr|Q8N9G1|Q8N9G1_HUMAN","tr|F1T0I1|F1T0I1_HUMAN;tr|J3KNL6|J3KNL6_HUMAN;sp|O15027|SC16A_HUMAN;tr|X6RGP5|X6RGP5_HUMAN;tr|A0A0C4DH09|A0A0C4DH09_HUMAN",5525,"F1T0I1","F1T0I1_HUMAN","Protein transport protein sec16 {ECO:0000256|RuleBase:RU364101}"]
["21.7853","19.8854","20.9461","21.8123","20.3887","21.3355",{"$nulls":3},"carbohydrate metabolic process","phosphotransferase activity, alcohol group as acceptor",null,"Metabolic pathways",null,null,10,10,10,"32.8","32.8","32.8","51.504",0,"73.505",450520000,41,"0.167399",1,"-0.306562","-0.44379","tr|A0A0B4J2A0|A0A0B4J2A0_HUMAN;sp|Q9UHJ6|SHPK_HUMAN","tr|A0A0B4J2A0|A0A0B4J2A0_HUMAN;sp|Q9UHJ6|SHPK_HUMAN",5456,"A0A0B4J2A0","A0A0B4J2A0_HUMAN"]
["20.2939","18.0827","19.5712","20.8146","18.4336","19.6246",{"$nulls":4},"metal ion binding;ubiquitin protein ligase activity","cytoplasm",{"$nulls":3},35,35,35,"18.3","18.3","18.3","289.38",0,"190.78",915360000,103,"0.118648",1,"-0.308375","-0.325749","sp|Q9ULT8|HECD1_HUMAN;tr|A0A087X2H1|A0A087X2H1_HUMAN;tr|H0YJP0|H0YJP0_HUMAN;tr|G3V4V5|G3V4V5_HUMAN;tr|H0YJD4|H0YJD4_HUMAN;tr|A0A087WVU6|A0A087WVU6_HUMAN","sp|Q9ULT8|HECD1_HUMAN;tr|A0A087X2H1|A0A087X2H1_HUMAN;tr|H0YJP0|H0YJP0_HUMAN",5131,"Q9ULT8","HECD1_HUMAN","E3 ubiquitin-protein ligase HECTD1",null,"HECTD1"]
["19.2349","17.328","19.245","18.8053","18.275","19.662",{"$nulls":3},"N-terminal peptidyl-methionine acetylation",null,"cytosol;Golgi apparatus;NatB complex",{"$nulls":3},15,15,15,"17.5","17.5","17.5","112.29",0,"49.101",387660000,34,"0.154314",1,"-0.311473","-0.412759","sp|Q14CX7|NAA25_HUMAN;tr|F8VSB9|F8VSB9_HUMAN","sp|Q14CX7|NAA25_HUMAN",2528,"Q14CX7","NAA25_HUMAN","N-alpha-acetyltransferase 25, NatB auxiliary subunit",null,"NAA25"]
["19.7782","20.417","19.634","20.8411","20.2419","19.6872",{"$nulls":3},"activation of MAPK activity;activation of protein kinase activity;cardiac muscle contraction;inflammatory response;positive regulation of protein kinase activity;positive regulation of transcription, DNA-templated;proteolysis in other organism;regulation of apoptotic process;regulation of cytokine biosynthetic process;regulation of mitotic cell cycle;signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;MAP kinase kinase activity;protein kinase binding;protein serine/threonine kinase activity;protein tyrosine kinase activity","cytoplasm;cytosol;membrane;nucleoplasm","Amyotrophic lateral sclerosis (ALS);Cellular senescence;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;GnRH signaling pathway;Hepatitis B;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;MAPK signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Rap1 signaling pathway;Thermogenesis;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Yersinia infection",null,null,12,12,11,"45.2","45.2","43.2","39.318",0,"64.039",569110000,70,"0.31173",1,"-0.313681","-0.763277","sp|P46734|MP2K3_HUMAN;tr|E9PRZ0|E9PRZ0_HUMAN;tr|J3QR49|J3QR49_HUMAN;tr|J3KRV4|J3KRV4_HUMAN;sp|P52564|MP2K6_HUMAN;tr|X6RB39|X6RB39_HUMAN;tr|J3QL77|J3QL77_HUMAN;tr|E9PMA8|E9PMA8_HUMAN","sp|P46734|MP2K3_HUMAN",1594,"P46734","MP2K3_HUMAN","Dual specificity mitogen-activated protein kinase kinase 3","AP kinase kinase 3;APKK 3","MAP2K3"]
["21.5367","18.5754","20.8363","20.7229","19.9966","21.1792",{"$nulls":3},"CMP salvage;CTP salvage;pyrimidine nucleobase metabolic process;pyrimidine nucleoside salvage;UMP salvage","ATP binding;nucleoside kinase activity;uridine kinase activity","cytosol","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,5,5,5,"28.4","28.4","28.4","29.299",0,"34.858",209560000,21,"0.120664",1,"-0.316743","-0.330771","sp|Q9BZX2|UCK2_HUMAN","sp|Q9BZX2|UCK2_HUMAN",4342,"Q9BZX2","UCK2_HUMAN","Uridine-cytidine kinase 2","CK 2","UCK2"]
["16.8955","15.0479","16.5144","17.6684","14.9444","16.7992",{"$nulls":3},"acetate biosynthetic process;acetyl-CoA biosynthetic process from acetate;ethanol oxidation;lipid biosynthetic process;mitochondrion organization;propionate biosynthetic process","acetate-CoA ligase activity;AMP binding;ATP binding","cytoplasm;cytosol;intracellular membrane-bounded organelle;mitochondrial matrix;nucleoplasm","Carbon metabolism;Glycolysis / Gluconeogenesis;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism",null,null,3,3,3,6,6,6,"78.579",0,"10.188",36340000,7,"0.118032",1,"-0.318078","-0.324212","sp|Q9NR19|ACSA_HUMAN;tr|F8WCJ4|F8WCJ4_HUMAN;tr|C9IYL0|C9IYL0_HUMAN;tr|B4DEH9|B4DEH9_HUMAN;tr|C9JY31|C9JY31_HUMAN","sp|Q9NR19|ACSA_HUMAN",4674,"Q9NR19","ACSA_HUMAN","Acetyl-coenzyme A synthetase, cytoplasmic",null,"ACSS2"]
["19.8198","20.1863","20.5935","20.8112","19.9021","20.8464",{"$nulls":3},"actin cytoskeleton organization;lamellipodium assembly;movement of cell or subcellular component;regulation of Arp2/3 complex-mediated actin nucleation;ruffle organization;small GTPase mediated signal transduction","cadherin binding;GTP binding;GTP-dependent protein binding;identical protein binding;phosphatidylinositol-4-phosphate binding;protein domain specific binding;Rac GTPase binding","cell cortex;cytoplasm;cytosol;plasma membrane;ruffle;trans-Golgi network membrane",{"$nulls":3},9,9,9,"40.5","40.5","40.5","37.855",0,"59.037",190780000,30,"0.34815",1,"-0.320051","-0.839187","sp|P53365|ARFP2_HUMAN;tr|A0A087X1E4|A0A087X1E4_HUMAN;tr|E9PRV8|E9PRV8_HUMAN;tr|E9PPY7|E9PPY7_HUMAN","sp|P53365|ARFP2_HUMAN;tr|A0A087X1E4|A0A087X1E4_HUMAN",1793,"P53365","ARFP2_HUMAN","Arfaptin-2",null,"ARFIP2"]
["22.2538","18.7957","21.1343","21.9167","19.7227","21.5048",{"$nulls":4},"protein heterodimerization activity",{"$nulls":4},3,3,3,"58.9","58.9","58.9","6.2643",0,"12.234",93347000,12,"0.0935843",1,"-0.320123","-0.262154","tr|E5RGS9|E5RGS9_HUMAN;sp|Q9NRG0|CHRC1_HUMAN","tr|E5RGS9|E5RGS9_HUMAN;sp|Q9NRG0|CHRC1_HUMAN",4689,"E5RGS9","E5RGS9_HUMAN",null,null,"CHRAC1"]
["21.8498","19.9676","20.4237","22.1539","19.8337","21.2203",{"$nulls":3},"glycoprotein catabolic process;N-acetylglucosamine metabolic process;protein deglycosylation;protein O-linked glycosylation","[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity;[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity;[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity;beta-N-acetylglucosaminidase activity;hyalurononglucosaminidase activity","cytosol;membrane;nucleus","Insulin resistance",null,null,25,25,25,"41.5","41.5","41.5","102.91",0,"216.64",1085300000,81,"0.134935",1,"-0.322299","-0.365952","sp|O60502|OGA_HUMAN;tr|H7C3X0|H7C3X0_HUMAN","sp|O60502|OGA_HUMAN",499,"O60502","OGA_HUMAN","Protein O-GlcNAcase {ECO:0000303|PubMed:11148210, ECO:0000303|PubMed:11788610}","GA {ECO:0000303|PubMed:20863279}","MGEA5"]
["20.2234","18.8125","19.3076","21.1904","18.698","19.4269",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;activation-induced cell death of T cells;cell aging;mitochondrial DNA replication;mitochondrion organization;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interferon-gamma-mediated signaling pathway;negative regulation of NF-kappaB transcription factor activity;negative regulation of programmed cell death;negative regulation of protein kinase activity;negative regulation of transcription from RNA polymerase II promoter;neuromuscular junction development;positive regulation of apoptotic process;positive regulation of protein ubiquitination;positive regulation of T cell proliferation;protein folding;protein stabilization;response to heat;response to interferon-gamma;skeletal muscle acetylcholine-gated channel clustering;small GTPase mediated signal transduction;T cell differentiation in thymus","ATP binding;GTPase regulator activity;Hsp70 protein binding;interferon-gamma receptor binding;metal ion binding;NF-kappaB binding;protein kinase binding;transcription factor binding;unfolded protein binding","cell junction;cytoplasm;cytosol;extrinsic component of plasma membrane;intracellular membrane-bounded organelle;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;neuromuscular junction;nucleus;postsynaptic membrane","Viral carcinogenesis",null,null,11,11,11,"28.5","28.5","28.5","52.488",0,"86.525",452830000,57,"0.14162",1,"-0.323924","-0.382219","sp|Q96EY1|DNJA3_HUMAN;tr|I3L1T6|I3L1T6_HUMAN","sp|Q96EY1|DNJA3_HUMAN",3867,"Q96EY1","DNJA3_HUMAN","DnaJ homolog subfamily A member 3, mitochondrial",null,"DNAJA3"]
["20.0807","19.8193","21.5432","21.3458","19.8052","21.2773",{"$nulls":3},"mitochondrion morphogenesis;negative regulation of macroautophagy;positive regulation of mitotic cell cycle","DNA binding","mitochondrial nucleoid;mitochondrion;nucleus",{"$nulls":3},11,11,11,"43.2","43.2","43.2","42.033",0,"68.92",379090000,32,"0.16867",1,"-0.328381","-0.446781","sp|Q9Y2S7|PDIP2_HUMAN;tr|B4DEM9|B4DEM9_HUMAN","sp|Q9Y2S7|PDIP2_HUMAN;tr|B4DEM9|B4DEM9_HUMAN",5240,"Q9Y2S7","PDIP2_HUMAN","Polymerase delta-interacting protein 2",null,"POLDIP2"]
["17.231","14.5963","15.2703","16.5058","14.6391","16.9481",{"$nulls":3},"cytoskeleton organization;Fc-gamma receptor signaling pathway involved in phagocytosis;NLS-bearing protein import into nucleus;positive regulation of neuron projection development;signal transduction","cytoskeletal protein binding;SH3 domain binding","cytosol;intermediate filament;nucleus",{"$nulls":3},3,3,3,"5.1","5.1","5.1","78.959","0.0030194","2.7283",15267000,3,"0.113474",1,"-0.331792","-0.3128","sp|Q9NZQ3|SPN90_HUMAN;tr|H7C2K2|H7C2K2_HUMAN","sp|Q9NZQ3|SPN90_HUMAN;tr|H7C2K2|H7C2K2_HUMAN",4888,"Q9NZQ3","SPN90_HUMAN","NCK-interacting protein with SH3 domain",null,"NCKIPSD"]
["18.9696","18.9896",1,1,"19.0544","19.9059",{"$nulls":5},"mitochondrion;plasma membrane",{"$nulls":3},2,2,2,"29.7","29.7","29.7","14.882",0,"6.7162",21828000,1,"0.0128253",1,"-0.333701","-0.0388116","tr|S4R360|S4R360_HUMAN;tr|J3KPP0|J3KPP0_HUMAN;sp|Q9Y6G3|RM42_HUMAN;tr|S4R2Z7|S4R2Z7_HUMAN","tr|S4R360|S4R360_HUMAN;tr|J3KPP0|J3KPP0_HUMAN;sp|Q9Y6G3|RM42_HUMAN;tr|S4R2Z7|S4R2Z7_HUMAN",5406,"S4R360","S4R360_HUMAN",null,null,"MRPL42"]
["21.6177","19.5132","20.6814","21.5479","20.3558","20.914",{"$nulls":4},"RNA binding",{"$nulls":4},14,11,10,"35.7","31.4",29,"63.674",0,"69.503",434650000,37,"0.182557",1,"-0.335147","-0.479204","tr|A0A087X0Q1|A0A087X0Q1_HUMAN;sp|Q7Z739|YTHD3_HUMAN;tr|A0A024R7W5|A0A024R7W5_HUMAN;tr|A0A087WY31|A0A087WY31_HUMAN;tr|A0A087X0C3|A0A087X0C3_HUMAN;tr|S4R373|S4R373_HUMAN","tr|A0A087X0Q1|A0A087X0Q1_HUMAN;sp|Q7Z739|YTHD3_HUMAN;tr|A0A024R7W5|A0A024R7W5_HUMAN;tr|A0A087WY31|A0A087WY31_HUMAN",3190,"A0A087X0Q1","A0A087X0Q1_HUMAN",null,null,"YTHDF3"]
["21.3726","20.1791","19.1694","20.9178","20.6142","20.1993",{"$nulls":3},"D-ribose metabolic process;pentose-phosphate shunt;pentose-phosphate shunt, non-oxidative branch","identical protein binding;monosaccharide binding;ribose-5-phosphate isomerase activity","cytosol;intracellular membrane-bounded organelle","Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,10,10,10,"42.1","42.1","42.1","33.269",0,"30.508",344020000,24,"0.192707",1,"-0.336734","-0.502621","sp|P49247|RPIA_HUMAN","sp|P49247|RPIA_HUMAN",1647,"P49247","RPIA_HUMAN","Ribose-5-phosphate isomerase",null,"RPIA"]
["20.6257","19.7361","21.056","21.0854","20.6062","20.7389",{"$nulls":3},"chromosome segregation;innate immune response;intracellular signal transduction;negative regulation of viral genome replication;positive regulation of viral genome replication;protein phosphorylation;regulation of mRNA processing;regulation of mRNA splicing, via spliceosome;RNA splicing;sperm chromatin condensation;spliceosomal complex assembly;viral process","ATP binding;magnesium ion binding;protein kinase activity;protein serine/threonine kinase activity;RNA binding","cytoplasm;cytosol;endoplasmic reticulum;nuclear matrix;nucleus;plasma membrane","Herpes simplex virus 1 infection",null,null,15,15,14,"33.9","33.9","32.5","74.324",0,"120.6",1738100000,152,"0.336614",1,"-0.337585","-0.815292","sp|Q96SB4|SRPK1_HUMAN;tr|H3BLV9|H3BLV9_HUMAN;tr|Q5R363|Q5R363_HUMAN;tr|D6RBF8|D6RBF8_HUMAN;tr|H0Y932|H0Y932_HUMAN;tr|D6RBM8|D6RBM8_HUMAN","sp|Q96SB4|SRPK1_HUMAN;tr|H3BLV9|H3BLV9_HUMAN;tr|Q5R363|Q5R363_HUMAN",4038,"Q96SB4","SRPK1_HUMAN","SRSF protein kinase 1",null,"SRPK1"]
["25.0894","22.5617","25.6196","25.4569","22.9968","25.8332",{"$nulls":3},"cellular response to leukemia inhibitory factor;liver regeneration;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleoplasm;small ribosomal subunit","Ribosome",null,null,14,14,14,"65.8","65.8","65.8","16.445",0,"172.68",41951000000,561,"0.0932384",1,"-0.33874","-0.26126","sp|P62249|RS16_HUMAN;tr|M0R210|M0R210_HUMAN;tr|A0A087WZ27|A0A087WZ27_HUMAN;tr|M0R3H0|M0R3H0_HUMAN;tr|M0R1M5|M0R1M5_HUMAN;tr|Q6IPX4|Q6IPX4_HUMAN;tr|M0QX76|M0QX76_HUMAN","sp|P62249|RS16_HUMAN;tr|M0R210|M0R210_HUMAN;tr|A0A087WZ27|A0A087WZ27_HUMAN;tr|M0R3H0|M0R3H0_HUMAN;tr|M0R1M5|M0R1M5_HUMAN;tr|Q6IPX4|Q6IPX4_HUMAN",1961,"P62249","RS16_HUMAN","40S ribosomal protein S16",null,"RPS16"]
["19.0556","19.4382","19.427","21.3187","18.3205","19.3001",{"$nulls":3},"lysosome localization;positive regulation of cell proliferation;positive regulation of gene expression;positive regulation of ruffle assembly;protein methylation","protein methyltransferase activity;RNA binding","tRNA-splicing ligase complex",{"$nulls":3},7,6,6,"23.1","20.4","20.4","55.4",0,"51.975",295570000,33,"0.141035",1,"-0.339499","-0.380799","sp|Q8NCA5|FA98A_HUMAN;tr|E9PH82|E9PH82_HUMAN;tr|C9J3G8|C9J3G8_HUMAN","sp|Q8NCA5|FA98A_HUMAN;tr|E9PH82|E9PH82_HUMAN",3471,"Q8NCA5","FA98A_HUMAN","Protein FAM98A",null,"FAM98A"]
["19.0466","18.9498","19.7696","20.254","18.8727","19.673",{"$nulls":3},"cell adhesion;multicellular organism development;negative regulation of fibroblast apoptotic process;regulation of cell proliferation;regulation of cell shape",null,"condensed chromosome kinetochore;nucleoplasm",{"$nulls":3},4,4,4,"17.4","17.4","17.4","33.592",0,"12.957",79990000,8,"0.2926",1,"-0.344553","-0.722808","sp|Q9UEE9|CFDP1_HUMAN","sp|Q9UEE9|CFDP1_HUMAN",4988,"Q9UEE9","CFDP1_HUMAN","Craniofacial development protein 1",null,"CFDP1"]
["22.1919","19.9388","22.2333","22.2593","20.8355","22.3049",{"$nulls":3},"galactitol metabolic process;galactose catabolic process;galactose metabolic process;glycolytic process from galactose","ATP binding;galactokinase activity;galactose binding","cytoplasm;cytosol;extracellular exosome;membrane","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Metabolic pathways",null,null,12,12,12,"37.8","37.8","37.8","42.272",0,"90.556",1140700000,36,"0.142443",1,"-0.34522","-0.384213","sp|P51570|GALK1_HUMAN;tr|K7ERJ9|K7ERJ9_HUMAN;tr|K7ERN9|K7ERN9_HUMAN;tr|K7EII7|K7EII7_HUMAN","sp|P51570|GALK1_HUMAN;tr|K7ERJ9|K7ERJ9_HUMAN",1739,"P51570","GALK1_HUMAN","Galactokinase",null,"GALK1"]
["21.642","19.7518","21.5945","21.8619","20.2797","21.8835",{"$nulls":3},"actin filament polymerization","actin binding;Rho GTPase binding",{"$nulls":4},37,37,37,34,34,34,"141.36",0,"303.01",1376500000,129,"0.158389",1,"-0.345613","-0.42247","tr|A0A0G2JH68|A0A0G2JH68_HUMAN;sp|O60610|DIAP1_HUMAN;tr|H9KV28|H9KV28_HUMAN;tr|B4E2I7|B4E2I7_HUMAN;tr|H7C2W8|H7C2W8_HUMAN;tr|E5RJ79|E5RJ79_HUMAN","tr|A0A0G2JH68|A0A0G2JH68_HUMAN;sp|O60610|DIAP1_HUMAN;tr|H9KV28|H9KV28_HUMAN",510,"A0A0G2JH68","A0A0G2JH68_HUMAN",null,null,"DIAPH1"]
["18.2111",1,"18.1577","19.1794",1,"18.237",{"$nulls":3},"astral microtubule organization;ciliary basal body-plasma membrane docking;cytokinesis;establishment of protein localization to membrane;establishment of protein localization to organelle;establishment of vesicle localization;exosomal secretion;melanosome transport;mitotic metaphase plate congression;mitotic spindle assembly;multivesicular body assembly;neuron projection development;neurotransmitter receptor transport, endosome to postsynaptic membrane;plasma membrane to endosome transport;positive regulation of axon extension;positive regulation of epithelial cell migration;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of protein localization to plasma membrane;post-translational protein modification;protein localization to plasma membrane;regulation of long-term neuronal synaptic plasticity;regulation of multivesicular body size;regulation of protein transport;regulation of vesicle-mediated transport;renal water homeostasis;vesicle-mediated transport","GTP binding;GTPase activity;microtubule binding;myosin V binding;syntaxin binding","axon;cleavage furrow;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;extracellular exosome;Golgi apparatus;mitochondrion;multivesicular body;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;postsynaptic recycling endosome;protein complex;recycling endosome;recycling endosome membrane;spindle pole;trans-Golgi network;transport vesicle;vesicle","Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Influenza A;Pancreatic secretion;Vasopressin-regulated water reabsorption",null,null,13,2,2,"72.2","24.5","24.5","24.393",0,"5.433",27661000,6,"0.0140397",1,"-0.349186","-0.04243","sp|P62491|RB11A_HUMAN;tr|H3BSC1|H3BSC1_HUMAN;tr|H3BMH2|H3BMH2_HUMAN;tr|B4DQU5|B4DQU5_HUMAN;tr|H3BN38|H3BN38_HUMAN","sp|P62491|RB11A_HUMAN;tr|H3BSC1|H3BSC1_HUMAN;tr|H3BMH2|H3BMH2_HUMAN",1982,"P62491","RB11A_HUMAN","Ras-related protein Rab-11A","ab-11","RAB11A"]
["17.6621","15.6312","17.5845","18.0678","16.0253","17.8358",{"$nulls":3},"cortical actin cytoskeleton organization;regulation of cell morphogenesis",null,"cytosol;extracellular exosome;nucleus",{"$nulls":3},4,4,4,"9.8","9.8","9.8","95.575",0,"9.5839",51391000,8,"0.139959",1,"-0.350375","-0.37819","sp|Q5VSL9|STRP1_HUMAN;sp|Q9ULQ0|STRP2_HUMAN","sp|Q5VSL9|STRP1_HUMAN",2894,"Q5VSL9","STRP1_HUMAN","Striatin-interacting protein 1",null,"STRIP1"]
["18.1265","16.2352",1,"18.5777","16.8359",1,{"$nulls":3},"actin cytoskeleton organization;chemical synaptic transmission;positive regulation of cell growth;positive regulation of cell migration;positive regulation of cell proliferation;Ras protein signal transduction","cell adhesion molecule binding;ephrin receptor binding;growth factor binding;interleukin-5 receptor binding;neurexin family protein binding;protein C-terminus binding;protein heterodimerization activity;protein homodimerization activity;syndecan binding","cytosol;interleukin-5 receptor complex;intracellular membrane-bounded organelle;nuclear membrane;nucleoplasm",{"$nulls":3},7,1,1,"41.8","5.3","5.3","34.819","0.0011926","3.4777",18635000,4,"0.0149112",1,"-0.350631","-0.0450211","tr|G5EA09|G5EA09_HUMAN","tr|G5EA09|G5EA09_HUMAN",5555,"G5EA09","G5EA09_HUMAN"]
["22.9517","22.2151","22.3817","23.6269","22.5296","22.4599",{"$nulls":3},"developmental process;protein folding","unfolded protein binding","condensed chromosome kinetochore;cytoplasm;cytosol;extracellular exosome;intracellular;microtubule cytoskeleton;microtubule organizing center;spindle pole",{"$nulls":3},7,7,7,"46.5","46.5","46.5","17.676",0,"34.778",441880000,36,"0.334637",1,"-0.355966","-0.811184","sp|Q8WVJ2|NUDC2_HUMAN;tr|E5RFP0|E5RFP0_HUMAN","sp|Q8WVJ2|NUDC2_HUMAN;tr|E5RFP0|E5RFP0_HUMAN",3620,"Q8WVJ2","NUDC2_HUMAN","NudC domain-containing protein 2",null,"NUDCD2"]
["23.5917","21.5976","23.5692","23.9303","22.2007","23.7005",{"$nulls":3},"DNA replication;DNA replication initiation;DNA unwinding involved in DNA replication;G1/S transition of mitotic cell cycle","ATP binding;DNA helicase activity;identical protein binding;single-stranded DNA binding","MCM complex;nuclear chromosome, telomeric region;nucleoplasm;nucleus","Cell cycle;DNA replication",null,null,35,35,35,"47.4","47.4","47.4","92.888",0,"323.31",4632000000,209,"0.156644",1,"-0.357649","-0.418317","sp|Q14566|MCM6_HUMAN","sp|Q14566|MCM6_HUMAN",2482,"Q14566","MCM6_HUMAN","DNA replication licensing factor MCM6",null,"MCM6"]
["19.5272","22.1513","19.005","17.1014","22.1849","22.48",{"$nulls":3},"ribosomal large subunit assembly","RNA binding","nucleolus;nucleus",{"$nulls":3},9,9,9,"28.9","28.9","28.9","41.401",0,"30.583",701360000,39,"0.0627438",1,"-0.360945","-0.180579","sp|Q8TDN6|BRX1_HUMAN","sp|Q8TDN6|BRX1_HUMAN",3565,"Q8TDN6","BRX1_HUMAN","Ribosome biogenesis protein BRX1 homolog",null,"BRIX1"]
["16.3479","14.3455","16.1419","17.0144","15.1212","15.7859",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell proliferation;microtubule-based movement;mitotic cell cycle;retrograde vesicle-mediated transport, Golgi to ER","ATP binding;ATPase activity;DNA binding;microtubule binding;microtubule motor activity;motor activity","centrosome;cytosol;membrane;microtubule;plus-end kinesin complex;spindle",{"$nulls":3},6,6,6,7,7,7,"160.16",0,"21.103",50119000,13,"0.161189",1,"-0.362074","-0.429118","sp|Q9NS87|KIF15_HUMAN;tr|C9JKA9|C9JKA9_HUMAN;tr|H7BZT2|H7BZT2_HUMAN;tr|D6RCT7|D6RCT7_HUMAN","sp|Q9NS87|KIF15_HUMAN;tr|C9JKA9|C9JKA9_HUMAN",4710,"Q9NS87","KIF15_HUMAN","Kinesin-like protein KIF15",null,"KIF15"]
["21.5434","20.4527","20.8749","21.2531","20.3008","22.416",{"$nulls":3},"attachment of spindle microtubules to kinetochore;cell division;chromosome segregation;mitotic cell cycle;mitotic spindle assembly;protein deubiquitination;protein K63-linked deubiquitination;response to ischemia","microtubule binding;polyubiquitin modification-dependent protein binding","BRISC complex;cytoplasm;cytosol;microtubule;spindle pole",{"$nulls":3},11,11,11,"35.7","35.7","35.7","46.9",0,"38.989",366590000,30,"0.205379",1,"-0.366291","-0.531543","sp|Q15018|F175B_HUMAN","sp|Q15018|F175B_HUMAN",2536,"Q15018","ABRX2_HUMAN","BRISC complex subunit Abraxas 2 {ECO:0000312|HGNC:HGNC:28975}",null,"ABRAXAS2"]
[1,"16.8618","17.2959","18.11",1,"17.1539",{"$nulls":3},"hemopoiesis;histone H2A-K119 monoubiquitination;negative regulation of G0 to G1 transition;negative regulation of gene expression, epigenetic;negative regulation of transcription from RNA polymerase II promoter;positive regulation of fibroblast proliferation;positive regulation of ubiquitin-protein transferase activity;regulation of gene expression;segment specification;transcription, DNA-templated","promoter-specific chromatin binding;RING-like zinc finger domain binding;zinc ion binding","cytosol;nuclear body;nucleoplasm;nucleus;PcG protein complex;PRC1 complex;ubiquitin ligase complex","MicroRNAs in cancer;Signaling pathways regulating pluripotency of stem cells;Transcriptional misregulation in cancer",null,null,3,3,3,"16.3","16.3","16.3","36.949",0,"8.5916",56334000,8,"0.0158423",1,"-0.368752","-0.0477838","sp|P35226|BMI1_HUMAN;tr|R4GMX3|R4GMX3_HUMAN;tr|Q5T8Z4|Q5T8Z4_HUMAN;tr|Q5T8Z6|Q5T8Z6_HUMAN;tr|Q5T8Z2|Q5T8Z2_HUMAN;tr|A0A087X259|A0A087X259_HUMAN;tr|J3KT13|J3KT13_HUMAN;tr|A0A024R1V6|A0A024R1V6_HUMAN;sp|P35227|PCGF2_HUMAN","sp|P35226|BMI1_HUMAN;tr|R4GMX3|R4GMX3_HUMAN;tr|Q5T8Z4|Q5T8Z4_HUMAN",1448,"P35226","BMI1_HUMAN","Polycomb complex protein BMI-1",null,"BMI1"]
["15.4905",1,"15.6165","16.4446",1,"15.7844",{"$nulls":3},"cell differentiation;cell migration;innate immune response;negative regulation of cell growth;negative regulation of Ras protein signal transduction;peptidyl-tyrosine autophosphorylation;protein autophosphorylation;protein phosphorylation;regulation of cell proliferation;transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding;non-membrane spanning protein tyrosine kinase activity;protein tyrosine kinase activity;receptor binding;signal transducer activity","cytoplasm;cytosol;extrinsic component of cytoplasmic side of plasma membrane;membrane",{"$nulls":3},3,3,3,6,6,6,"72.467","0.00021542","5.058",20828000,3,"0.017759",1,"-0.374007","-0.0534544","sp|Q13470|TNK1_HUMAN;tr|I3L334|I3L334_HUMAN","sp|Q13470|TNK1_HUMAN",2366,"Q13470","TNK1_HUMAN","Non-receptor tyrosine-protein kinase TNK1",null,"TNK1"]
["23.6266","23.9022","24.0524","24.1236","24.2641","24.3185",{"$nulls":3},"multicellular organism development;platelet degranulation","cytokine activity","extracellular exosome;extracellular region;platelet dense granule lumen",{"$nulls":3},9,9,9,"45.4","45.4","45.4","24.68",0,"101.36",2009000000,67,"1.27861",1,"-0.375013","-2.7262","sp|Q92520|FAM3C_HUMAN;tr|C9JP35|C9JP35_HUMAN;tr|C9JMN4|C9JMN4_HUMAN","sp|Q92520|FAM3C_HUMAN",3667,"Q92520","FAM3C_HUMAN","Protein FAM3C",null,"FAM3C"]
["19.0753","18.8997","18.645","19.4377","18.6881","19.6303",{"$nulls":3},"angiogenesis;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;apolipoprotein A-I-mediated signaling pathway;apoptotic cell clearance;calcium ion transmembrane transport;cell adhesion;cell adhesion mediated by integrin;cell-matrix adhesion;cell-substrate adhesion;endodermal cell differentiation;entry of symbiont into host cell by promotion of host phagocytosis;ERK1 and ERK2 cascade;extracellular matrix organization;extrinsic apoptotic signaling pathway in absence of ligand;heterotypic cell-cell adhesion;integrin-mediated signaling pathway;leukocyte migration;negative chemotaxis;negative regulation of entry of bacterium into host cell;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of lipid storage;negative regulation of lipid transport;negative regulation of lipoprotein metabolic process;negative regulation of low-density lipoprotein particle receptor biosynthetic process;negative regulation of macrophage derived foam cell differentiation;neutrophil degranulation;positive regulation of cell adhesion;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of cytosolic calcium ion concentration;positive regulation of MAPK cascade;positive regulation of osteoblast proliferation;regulation of apoptotic cell clearance;regulation of phagocytosis;substrate adhesion-dependent cell spreading;transforming growth factor-beta secretion;vascular endothelial growth factor receptor signaling pathway;vasculogenesis;viral entry into host cell","coreceptor activity;extracellular matrix binding;extracellular matrix protein binding;fibronectin binding;metal ion binding;opsonin binding;peptide binding;protease binding;protein kinase C binding;receptor binding;transforming growth factor beta binding;virus receptor activity;voltage-gated calcium channel activity","alphav-beta3 integrin-IGF-1-IGF1R complex;cell surface;cytosol;external side of plasma membrane;extracellular exosome;filopodium membrane;focal adhesion;integral component of plasma membrane;integrin alphav-beta3 complex;integrin alphav-beta5 complex;integrin alphav-beta6 complex;integrin alphav-beta8 complex;integrin complex;lamellipodium membrane;membrane;microvillus membrane;phagocytic vesicle;plasma membrane;ruffle membrane;specific granule membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Cell adhesion molecules (CAMs);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Fluid shear stress and atherosclerosis;Focal adhesion;Human cytomegalovirus infection;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);Pathways in cancer;Phagosome;PI3K-Akt signaling pathway;Proteoglycans in cancer;Regulation of actin cytoskeleton;Small cell lung cancer;Thyroid hormone signaling pathway",null,null,14,14,14,"21.1","21.1","21.1","116.04",0,"45.033",308970000,22,"0.532581",1,"-0.378735","-1.20861","sp|P06756|ITAV_HUMAN;tr|H7BZG1|H7BZG1_HUMAN","sp|P06756|ITAV_HUMAN",923,"P06756","ITAV_HUMAN","Integrin alpha-V",null,"ITGAV"]
["20.0197","17.0848","19.9894","20.4538","17.8118","19.9727",{"$nulls":3},"DNA replication","3'-5' exonuclease activity;4 iron, 4 sulfur cluster binding;DNA binding;DNA-directed DNA polymerase activity;metal ion binding;nucleoside binding;nucleotide binding","cytosol;nucleoplasm",{"$nulls":3},9,9,9,"10.7","10.7","10.7","165.77",0,"31.111",956250000,29,"0.108738",1,"-0.381444","-0.300867","tr|A0A087WU64|A0A087WU64_HUMAN;sp|P09884|DPOLA_HUMAN;tr|A6NMQ1|A6NMQ1_HUMAN","tr|A0A087WU64|A0A087WU64_HUMAN;sp|P09884|DPOLA_HUMAN;tr|A6NMQ1|A6NMQ1_HUMAN",1001,"A0A087WU64","A0A087WU64_HUMAN","DNA polymerase {ECO:0000256|RuleBase:RU000442}",null,"POLA1"]
["18.5918","16.3533","17.4344","18.0451","17.7212","17.7667",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;intracellular protein transport;intra-Golgi vesicle-mediated transport;protein glycosylation;protein localization to organelle;protein stabilization;retrograde vesicle-mediated transport, Golgi to ER","protein transporter activity","cis-Golgi network;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;Golgi transport complex;trans-Golgi network membrane",{"$nulls":3},8,8,8,12,12,12,"94.095",0,"16.251",121390000,11,"0.230403",1,"-0.384486","-0.587719","sp|Q96JB2|COG3_HUMAN;tr|A0A087WTH9|A0A087WTH9_HUMAN","sp|Q96JB2|COG3_HUMAN",3935,"Q96JB2","COG3_HUMAN","Conserved oligomeric Golgi complex subunit 3","OG complex subunit 3","COG3"]
["21.1034","20.2455","20.9622","21.4206","20.4271","21.6184",{"$nulls":3},"cellular protein modification process;epidermis development;hydroxylysine biosynthetic process;oxidation-reduction process;peptidyl-lysine hydroxylation;response to hypoxia","iron ion binding;L-ascorbic acid binding;procollagen-lysine 5-dioxygenase activity;protein homodimerization activity","catalytic complex;endoplasmic reticulum membrane;extracellular exosome;rough endoplasmic reticulum membrane","Lysine degradation",null,null,23,23,23,"41.4","41.4","41.4","83.549",0,"120.67",1055300000,83,"0.352162",1,"-0.385004","-0.847466","sp|Q02809|PLOD1_HUMAN;tr|Q5JXB7|Q5JXB7_HUMAN;tr|Q5JXB8|Q5JXB8_HUMAN","sp|Q02809|PLOD1_HUMAN",2163,"Q02809","PLOD1_HUMAN","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",null,"PLOD1"]
["24.8517","23.6871","24.9184","25.0331","24.3588","25.23",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;cellular hyperosmotic response;cellular response to tumor necrosis factor;fertilization;in utero embryonic development;male gonad development;negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;negative regulation of necroptotic process;negative regulation of skeletal muscle tissue development;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cytoplasmic translation;positive regulation of organ growth;response to cold;spermatogenesis;transcription, DNA-templated","DNA binding transcription factor activity;double-stranded DNA binding;mRNA 3'-UTR binding;Rho GTPase binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;single-stranded DNA binding;transcription corepressor activity;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","bicellular tight junction;cytoplasm;cytosol;nucleus;perinuclear region of cytoplasm;polysome","Tight junction",null,null,15,11,11,"64.5","54.6","54.6","40.089",0,"308.32",3502300000,104,"0.334376",1,"-0.388259","-0.810641","sp|P16989|YBOX3_HUMAN;tr|A0A0D9SEI8|A0A0D9SEI8_HUMAN","sp|P16989|YBOX3_HUMAN",1142,"P16989","YBOX3_HUMAN","Y-box-binding protein 3",null,"YBX3"]
["17.5198","16.6956","18.5632","17.9482","17.3695","18.6327",{"$nulls":3},"branching morphogenesis of an epithelial tube;cell proliferation;cell surface receptor signaling pathway;endothelial cell morphogenesis;entry of bacterium into host cell;establishment of skin barrier;MAPK cascade;negative regulation of autophagy;negative regulation of guanyl-nucleotide exchange factor activity;negative regulation of hydrogen peroxide-mediated programmed cell death;negative regulation of Rho protein signal transduction;negative regulation of stress fiber assembly;negative regulation of thrombin-activated receptor signaling pathway;positive chemotaxis;positive regulation of endothelial cell chemotaxis;positive regulation of microtubule polymerization;positive regulation of protein kinase B signaling;positive regulation of transcription from RNA polymerase II promoter;semaphorin-plexin signaling pathway;signal transduction","ATP binding;hepatocyte growth factor-activated receptor activity;identical protein binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;protein phosphatase binding;protein tyrosine kinase activity;Ras guanyl-nucleotide exchange factor activity","basal plasma membrane;cell surface;extracellular region;integral component of membrane;integral component of plasma membrane;intracellular;plasma membrane","Adherens junction;Axon guidance;Bacterial invasion of epithelial cells;Central carbon metabolism in cancer;EGFR tyrosine kinase inhibitor resistance;Epithelial cell signaling in Helicobacter pylori infection;Focal adhesion;Gastric cancer;Hepatocellular carcinoma;Malaria;MAPK signaling pathway;Melanoma;MicroRNAs in cancer;Pathways in cancer;PI3K-Akt signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Renal cell carcinoma;Transcriptional misregulation in cancer",null,null,14,14,13,"13.4","13.4","12.8","155.54",0,"35.401",245880000,30,"0.235483",1,"-0.390612","-0.598983","sp|P08581|MET_HUMAN;tr|H7C174|H7C174_HUMAN;tr|H7C130|H7C130_HUMAN","sp|P08581|MET_HUMAN",968,"P08581","MET_HUMAN","Hepatocyte growth factor receptor","GF receptor","MET"]
["16.3597","16.1881","16.391","16.8752","16.1348","17.1031",{"$nulls":3},"regulation of transcription, DNA-templated;RNA splicing;transcription, DNA-templated","double-stranded DNA binding;RNA binding;zinc ion binding","cytoplasm;intracellular membrane-bounded organelle;nuclear speck;nucleoplasm",{"$nulls":3},15,15,12,"11.4","11.4","9.7","220.62",0,"46.518",234170000,41,"0.584001",1,"-0.391448","-1.30918","sp|Q14966|ZN638_HUMAN;tr|A0A096LPK8|A0A096LPK8_HUMAN;tr|C9JWN0|C9JWN0_HUMAN","sp|Q14966|ZN638_HUMAN",2517,"Q14966","ZN638_HUMAN","Zinc finger protein 638",null,"ZNF638"]
["23.2811","22.2002","22.803","23.646","22.5618","23.259",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway",null,"cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nuclear proteasome complex;nucleoplasm;proteasome accessory complex;proteasome complex;proteasome regulatory particle;proteasome regulatory particle, lid subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,22,22,22,52,52,52,"52.904",0,"323.31",2273400000,126,"0.370359",1,"-0.394167","-0.88484","sp|O00232|PSD12_HUMAN;tr|J3KTJ5|J3KTJ5_HUMAN;tr|J3KSK1|J3KSK1_HUMAN","sp|O00232|PSD12_HUMAN",215,"O00232","PSD12_HUMAN","26S proteasome non-ATPase regulatory subunit 12",null,"PSMD12"]
["16.3848","16.1901","16.6301","16.6323","17.177","16.5824",{"$nulls":3},"leukocyte migration;protein folding;protein localization to plasma membrane;protein polyubiquitination","peptidyl-prolyl cis-trans isomerase activity;ubiquitin protein ligase activity;ubiquitin-ubiquitin ligase activity","cytoplasm;Golgi lumen;nucleoplasm;nucleus;plasma membrane","Ubiquitin mediated proteolysis",null,null,2,2,2,"5.6","5.6","5.6","58.823","0.00081566","3.8948",38010000,3,"0.797761",1,"-0.395512","-1.72663","sp|Q13356|PPIL2_HUMAN","sp|Q13356|PPIL2_HUMAN",2341,"Q13356","PPIL2_HUMAN","Peptidyl-prolyl cis-trans isomerase-like 2 {ECO:0000305}","PIase {ECO:0000305}","PPIL2"]
["19.3046","18.4086","19.2577","20.0849","18.8246","19.2666",{"$nulls":3},"DNA replication","DNA binding;DNA-directed DNA polymerase activity","nucleoplasm",{"$nulls":3},7,7,7,"20.4","20.4","20.4","49.612",0,"23.131",171760000,13,"0.355564",1,"-0.401742","-0.854476","tr|F8W8R3|F8W8R3_HUMAN;sp|P49005|DPOD2_HUMAN;tr|A0A087WWF6|A0A087WWF6_HUMAN;tr|C9IZD2|C9IZD2_HUMAN;tr|C9J8Z7|C9J8Z7_HUMAN;tr|C9JLE1|C9JLE1_HUMAN;tr|C9JHC7|C9JHC7_HUMAN;tr|H7C1B3|H7C1B3_HUMAN","tr|F8W8R3|F8W8R3_HUMAN;sp|P49005|DPOD2_HUMAN;tr|A0A087WWF6|A0A087WWF6_HUMAN;tr|C9IZD2|C9IZD2_HUMAN;tr|C9J8Z7|C9J8Z7_HUMAN;tr|C9JLE1|C9JLE1_HUMAN",1641,"F8W8R3","F8W8R3_HUMAN",null,null,"POLD2"]
["14.3297",1,"13.7194","15.35",1,"13.9107",{"$nulls":5},"integral component of membrane;membrane",{"$nulls":3},8,8,8,"5.6","5.6","5.6","205.14",0,"23.707",111160000,20,"0.0213814",1,"-0.403911","-0.0641084","sp|Q92545|TM131_HUMAN;tr|H7BZV0|H7BZV0_HUMAN","sp|Q92545|TM131_HUMAN",3677,"Q92545","TM131_HUMAN","Transmembrane protein 131",null,"TMEM131"]
["20.8948","20.7736","20.2439","21.7999","20.4687","20.8575",{"$nulls":3},"actin cytoskeleton organization;activation of GTPase activity;establishment of protein localization;negative regulation of epithelial cell migration;negative regulation of focal adhesion assembly;negative regulation of protein kinase activity by regulation of protein phosphorylation;negative regulation of protein phosphorylation;negative regulation of substrate adhesion-dependent cell spreading;neural crest cell migration;phagocytosis;positive regulation of lamellipodium morphogenesis;regulation of epithelial cell migration;regulation of fibroblast migration;regulation of focal adhesion assembly;regulation of protein phosphorylation;regulation of ruffle assembly;regulation of substrate adhesion-dependent cell spreading;signal transduction","actin filament binding;Rac GTPase binding","actin cytoskeleton;cytoplasm;flotillin complex;focal adhesion;lamellipodium;lateral plasma membrane",{"$nulls":3},9,9,9,"26.6","26.6","26.6","53.248",0,"67.642",326710000,25,"0.384448",1,"-0.404607","-0.913584","sp|Q9ULV4|COR1C_HUMAN;tr|B4E3S0|B4E3S0_HUMAN;tr|H0YHL7|H0YHL7_HUMAN;tr|F8W1H8|F8W1H8_HUMAN;tr|F8VUX3|F8VUX3_HUMAN;tr|F8VSA4|F8VSA4_HUMAN;tr|F8VRE9|F8VRE9_HUMAN;tr|F8VTT6|F8VTT6_HUMAN;tr|F8VVB7|F8VVB7_HUMAN;tr|F8VV53|F8VV53_HUMAN","sp|Q9ULV4|COR1C_HUMAN;tr|B4E3S0|B4E3S0_HUMAN",5134,"Q9ULV4","COR1C_HUMAN","Coronin-1C",null,"CORO1C"]
["17.6052",1,"16.0597","18.9246",1,"15.9641",{"$nulls":3},"cell migration;defense response to virus;double-strand break repair;innate immune response;NAD biosynthesis via nicotinamide riboside salvage pathway;negative regulation of catalytic activity;negative regulation of gene expression;negative regulation of transcription from RNA polymerase II promoter;positive regulation of chromatin binding;positive regulation of defense response to virus by host;positive regulation of double-strand break repair via nonhomologous end joining;positive regulation of interferon-gamma-mediated signaling pathway;positive regulation of protein localization to nucleus;positive regulation of transcription, DNA-templated;positive regulation of tyrosine phosphorylation of STAT protein;posttranscriptional regulation of gene expression;protein ADP-ribosylation;regulation of response to interferon-gamma","ADP-D-ribose binding;enzyme binding;enzyme inhibitor activity;histone binding;NAD+ ADP-ribosyltransferase activity;STAT family protein binding;transcriptional repressor activity, RNA polymerase II transcription factor binding;ubiquitin-like protein ligase binding","cytoplasm;cytosol;membrane;mitochondrion;nucleoplasm;nucleus;protein complex;site of DNA damage",{"$nulls":3},14,14,14,21,21,21,"96.342",0,"70.232",252990000,35,"0.0176679",1,"-0.407927","-0.0531853","sp|Q8IXQ6|PARP9_HUMAN;tr|G5E9U8|G5E9U8_HUMAN;tr|C9K0E5|C9K0E5_HUMAN","sp|Q8IXQ6|PARP9_HUMAN",3324,"Q8IXQ6","PARP9_HUMAN","Poly [ADP-ribose] polymerase 9","ARP-9","PARP9"]
["18.4545","17.3117","17.615","19.0802","17.2754","18.2564",{"$nulls":3},"intracellular signal transduction","actin binding;ATP binding;GTPase activator activity;metal ion binding;motor activity","cytosol;myosin complex",{"$nulls":3},51,51,49,"33.5","33.5","32.7","243.4",0,"289.81",1598300000,176,"0.262335",1,"-0.410243","-0.657804","tr|M0R0P8|M0R0P8_HUMAN;sp|Q13459|MYO9B_HUMAN;tr|M0R300|M0R300_HUMAN;tr|M0QZY4|M0QZY4_HUMAN;tr|M0R240|M0R240_HUMAN;tr|M0QXP0|M0QXP0_HUMAN;tr|M0R2J3|M0R2J3_HUMAN;tr|M0R332|M0R332_HUMAN","tr|M0R0P8|M0R0P8_HUMAN;sp|Q13459|MYO9B_HUMAN;tr|M0R300|M0R300_HUMAN",2364,"M0R0P8","M0R0P8_HUMAN",null,null,"MYO9B"]
["20.2926","20.0607","22.6381","22.0157","19.7438","22.4637",{"$nulls":5},"nucleoplasm",{"$nulls":3},5,5,5,"23.1","23.1","23.1","17.546",0,"19.717",602130000,70,"0.127902",1,"-0.410606","-0.348692","tr|J3QLE5|J3QLE5_HUMAN;sp|P63162|RSMN_HUMAN;sp|P14678|RSMB_HUMAN;tr|A8MT02|A8MT02_HUMAN;tr|J3KRY3|J3KRY3_HUMAN;tr|S4R3P3|S4R3P3_HUMAN","tr|J3QLE5|J3QLE5_HUMAN;sp|P63162|RSMN_HUMAN;sp|P14678|RSMB_HUMAN;tr|A8MT02|A8MT02_HUMAN",1106,"J3QLE5","J3QLE5_HUMAN",null,null,"SNRPN"]
["21.1942","18.3172","18.2202","21.3003","18.9918","18.672",{"$nulls":3},"autophagosome assembly;autophagy of mitochondrion;autophagy of nucleus;cellular protein modification process;macroautophagy;mitochondrial fragmentation involved in apoptotic process;negative regulation of phagocytosis;protein targeting to membrane;protein ubiquitination;regulation of cilium assembly","Atg12 transferase activity;Atg8 ligase activity;enzyme binding;ligase activity;ubiquitin-like protein transferase activity","cytoplasmic ubiquitin ligase complex;cytosol","Autophagy - animal;Autophagy - other;Kaposi sarcoma-associated herpesvirus infection",null,null,5,5,5,"19.1","19.1","19.1","35.864",0,"34.595",99311000,9,"0.116774",1,"-0.41083","-0.32107","sp|Q9NT62|ATG3_HUMAN;tr|F8WDI0|F8WDI0_HUMAN","sp|Q9NT62|ATG3_HUMAN",4718,"Q9NT62","ATG3_HUMAN","Ubiquitin-like-conjugating enzyme ATG3",null,"ATG3"]
["21.8739","19.7025","21.157","22.2892","20.1463","21.5496",{"$nulls":3},"angiogenesis;apoptotic process;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;positive regulation of angiogenesis;positive regulation of endothelial cell proliferation;queuosine biosynthetic process;regulation of peptidyl-tyrosine phosphorylation;viral process","protein binding involved in protein folding;vascular endothelial growth factor receptor 2 binding","cytoplasm;cytosol;nucleus",{"$nulls":3},9,9,9,"45.6","45.6","45.6","27.614",0,"71.646",355470000,33,"0.176721",1,"-0.417241","-0.465633","sp|Q9H2J4|PDCL3_HUMAN;tr|H7BZP2|H7BZP2_HUMAN;tr|C9JST4|C9JST4_HUMAN","sp|Q9H2J4|PDCL3_HUMAN",4431,"Q9H2J4","PDCL3_HUMAN","Phosducin-like protein 3",null,"PDCL3"]
["19.0493","18.4467","18.2498","19.6165","18.6124","18.7774",{"$nulls":3},"branching morphogenesis of an epithelial tube;cell cycle phase transition;cell division;cellular response to bleomycin;cellular response to cisplatin;cellular response to DNA damage stimulus;cellular response to hydroxyurea;circadian rhythm;detection of abiotic stimulus;DNA replication;lung development;morphogenesis of an epithelium;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of double-strand break repair;regulation of circadian rhythm;response to abiotic stimulus;transcription, DNA-templated","protein heterodimerization activity;protein homodimerization activity","nuclear chromatin;nucleoplasm;nucleus",{"$nulls":3},27,27,27,"26.2","26.2","26.2","138.66",0,"130.72",1065900000,87,"0.461788",1,"-0.420162","-1.06894","sp|Q9UNS1|TIM_HUMAN","sp|Q9UNS1|TIM_HUMAN",5161,"Q9UNS1","TIM_HUMAN","Protein timeless homolog","TIM","TIMELESS"]
["19.0417","18.3129","18.9864","19.6196","18.3201","19.6665",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding","cytosol;mitochondrion",{"$nulls":3},23,23,23,"23.3","23.3","23.3","130.55",0,"74.988",489450000,39,"0.350624",1,"-0.421751","-0.844295","tr|H7BXY3|H7BXY3_HUMAN;sp|Q7L2E3|DHX30_HUMAN","tr|H7BXY3|H7BXY3_HUMAN;sp|Q7L2E3|DHX30_HUMAN",3118,"H7BXY3","H7BXY3_HUMAN",null,null,"DHX30"]
["19.3129","18.4619","17.321","19.5482","18.4229","18.3984",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell differentiation;cell division;microtubule cytoskeleton organization;microtubule depolymerization;microtubule-based movement;mitotic spindle assembly;mitotic spindle organization;nervous system development;regulation of cell migration;retrograde vesicle-mediated transport, Golgi to ER;sister chromatid cohesion","ATP binding;ATPase activity;microtubule binding;microtubule motor activity;motor activity","centriolar subdistal appendage;centriole;centrosome;cytoplasm;cytosol;kinesin complex;membrane;microtubule;nuclear body;nucleolus;nucleus;sperm principal piece;spindle pole",{"$nulls":3},22,22,14,"33.7","33.7","21.8","79.954",0,"82.512",514530000,75,"0.242679",1,"-0.424568","-0.614862","sp|O00139|KIF2A_HUMAN;tr|H0Y5Z9|H0Y5Z9_HUMAN;tr|H0Y8H2|H0Y8H2_HUMAN","sp|O00139|KIF2A_HUMAN",201,"O00139","KIF2A_HUMAN","Kinesin-like protein KIF2A",null,"KIF2A"]
["14.3963","15.4765","17.518","16.2374","16.8943","15.5486",{"$nulls":3},"activation of GTPase activity;apoptotic process;cardiac muscle hypertrophy;cell migration;cell-matrix adhesion;ephrin receptor signaling pathway;G-protein coupled receptor signaling pathway;neuron projection extension;NMDA selective glutamate receptor signaling pathway;positive regulation of apoptotic process;positive regulation of axonogenesis;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of dendritic spine morphogenesis;positive regulation of epithelial to mesenchymal transition;positive regulation of JUN kinase activity;positive regulation of protein binding;positive regulation of Schwann cell chemotaxis;protein localization to membrane;Rac protein signal transduction;regulation of dopaminergic neuron differentiation;regulation of epithelial to mesenchymal transition;regulation of ERK1 and ERK2 cascade;regulation of insulin secretion involved in cellular response to glucose stimulus;regulation of modification of postsynaptic actin cytoskeleton;regulation of non-canonical Wnt signaling pathway;regulation of Rho protein signal transduction;regulation of small GTPase mediated signal transduction;response to cocaine;Wnt signaling pathway, planar cell polarity pathway","guanyl-nucleotide exchange factor activity;kinase binding;lipid binding;microtubule binding;Rac guanyl-nucleotide exchange factor activity;receptor tyrosine kinase binding;Rho guanyl-nucleotide exchange factor activity;signal transducer activity, downstream of receptor","axonal growth cone;cell-cell contact zone;cell-cell junction;cytosol;dendritic spine;extrinsic component of cytoplasmic side of plasma membrane;main axon;microtubule;neuronal cell body;nucleus;plasma membrane;postsynaptic density;ruffle membrane","cAMP signaling pathway;Chemokine signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Tight junction",null,null,34,34,34,"31.2","31.2","31.2","177.51",0,"176.93",805180000,106,"0.162533",1,"-0.429848","-0.432301","sp|Q13009|TIAM1_HUMAN;tr|C9JMB5|C9JMB5_HUMAN;tr|H7C079|H7C079_HUMAN","sp|Q13009|TIAM1_HUMAN",2293,"Q13009","TIAM1_HUMAN","T-lymphoma invasion and metastasis-inducing protein 1","IAM-1","TIAM1"]
["19.8027","18.6445","18.0999","19.7674","19.2274","18.847",{"$nulls":3},"actin cytoskeleton reorganization;activation of JNKK activity;cytoskeleton organization;intracellular signal transduction;microvillus assembly;positive regulation of protein phosphorylation;protein autophosphorylation;protein localization to plasma membrane;protein phosphorylation;regulation of apoptotic process;regulation of dendrite morphogenesis;regulation of mitotic cell cycle;Wnt signaling pathway","ATP binding;MAP kinase kinase kinase kinase activity;protein kinase activity;protein serine/threonine kinase activity","apical plasma membrane;cytoplasm;cytoskeleton;cytosol;extracellular exosome;nucleoplasm;nucleus;recycling endosome",{"$nulls":3},30,19,19,"31.3","23.8","23.8","154.94",0,"113.31",982240000,94,"0.309662",1,"-0.431598","-0.758925","sp|Q9UKE5|TNIK_HUMAN;tr|C9J338|C9J338_HUMAN;tr|I3L203|I3L203_HUMAN;tr|I3L1U1|I3L1U1_HUMAN","sp|Q9UKE5|TNIK_HUMAN",5086,"Q9UKE5","TNIK_HUMAN","TRAF2 and NCK-interacting protein kinase",null,"TNIK"]
["20.3249","19.4276","21.3987","21.2019","19.7162","21.5307",{"$nulls":3},"transport","ATP binding;ATPase activity;transporter activity","ATP-binding cassette (ABC) transporter complex;membrane;mitochondrial envelope",{"$nulls":3},24,24,24,"38.8","38.8","38.8","71.289",0,"88.193",2308200000,164,"0.210131",1,"-0.432547","-0.542303","sp|Q9UG63|ABCF2_HUMAN;tr|C9JHK9|C9JHK9_HUMAN;tr|C9JZV3|C9JZV3_HUMAN","sp|Q9UG63|ABCF2_HUMAN;tr|C9JHK9|C9JHK9_HUMAN;tr|C9JZV3|C9JZV3_HUMAN",4999,"Q9UG63","ABCF2_HUMAN","ATP-binding cassette sub-family F member 2",null,"ABCF2"]
["18.3183","17.1692",1,"19.6517","17.1372",1,{"$nulls":9},1,1,1,"11.9","11.9","11.9","16.132","0.0011799","3.3118",10841000,2,"0.0178222",1,"-0.433813","-0.0536407","tr|C9J173|C9J173_HUMAN;tr|B8ZZF6|B8ZZF6_HUMAN;tr|E7ET59|E7ET59_HUMAN;tr|E7EUX4|E7EUX4_HUMAN;tr|E7ENF2|E7ENF2_HUMAN;sp|P49441|INPP_HUMAN","tr|C9J173|C9J173_HUMAN;tr|B8ZZF6|B8ZZF6_HUMAN;tr|E7ET59|E7ET59_HUMAN;tr|E7EUX4|E7EUX4_HUMAN;tr|E7ENF2|E7ENF2_HUMAN;sp|P49441|INPP_HUMAN",1661,"C9J173","C9J173_HUMAN",null,null,"INPP1"]
["20.8902","17.1479","21.3354","20.7167","19.0253","20.9516",{"$nulls":3},"cellular protein modification process;mRNA processing;regulation of double-strand break repair via homologous recombination;RNA splicing","protein binding, bridging;protein phosphatase regulator activity","centrosome;cytoplasm;nucleoplasm;nucleus;protein phosphatase 4 complex",{"$nulls":3},10,10,10,"41.7","41.7","41.7","46.898",0,"59.268",284870000,27,"0.108962",1,"-0.440072","-0.301434","sp|Q9NY27|PP4R2_HUMAN;tr|C9IZ04|C9IZ04_HUMAN;tr|H7C559|H7C559_HUMAN;tr|F8WDK3|F8WDK3_HUMAN","sp|Q9NY27|PP4R2_HUMAN;tr|C9IZ04|C9IZ04_HUMAN",4842,"Q9NY27","PP4R2_HUMAN","Serine/threonine-protein phosphatase 4 regulatory subunit 2",null,"PPP4R2"]
["17.5394","17.2092","18.3116","18.4347","17.4287","18.5278",{"$nulls":3},"circadian regulation of gene expression;negative regulation of epithelial cell proliferation;negative regulation of transcription, DNA-templated;positive regulation of apoptotic signaling pathway;positive regulation of branching involved in ureteric bud morphogenesis;positive regulation of MAP kinase activity;positive regulation of transcription, DNA-templated;regulation of apoptotic process;regulation of circadian rhythm;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated","identical protein binding;transcription coactivator activity","chromatin;cytoplasm;nucleus;plasma membrane;protein complex","Neurotrophin signaling pathway",null,null,3,2,2,"5.4","3.9","3.9","86.16",0,"174.54",106120000,14,"0.389618",1,"-0.443653","-0.924091","sp|Q9Y5V3|MAGD1_HUMAN","sp|Q9Y5V3|MAGD1_HUMAN",5371,"Q9Y5V3","MAGD1_HUMAN","Melanoma-associated antigen D1",null,"MAGED1"]
["19.3769","18.26","18.8412","20.2566","18.6039","18.9589",{"$nulls":3},"cardiac left ventricle morphogenesis;cellular response to insulin stimulus;cellular response to interleukin-3;chemical synaptic transmission, postsynaptic;dopamine receptor signaling pathway;extrinsic apoptotic signaling pathway in absence of ligand;glycogen metabolic process;insulin receptor signaling pathway;IRE1-mediated unfolded protein response;negative regulation of canonical Wnt signaling pathway;negative regulation of cell growth involved in cardiac muscle cell development;negative regulation of glucose import;negative regulation of glycogen (starch) synthase activity;negative regulation of glycogen biosynthetic process;negative regulation of glycogen synthase activity, transferring glucose-1-phosphate;negative regulation of insulin receptor signaling pathway;negative regulation of TOR signaling;negative regulation of type B pancreatic cell development;negative regulation of UDP-glucose catabolic process;nervous system development;peptidyl-threonine phosphorylation;positive regulation of adrenergic receptor signaling pathway;positive regulation of amyloid-beta formation;positive regulation of cAMP biosynthetic process;positive regulation of gene expression;positive regulation of glycogen (starch) synthase activity;positive regulation of heart contraction;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein catabolic process;positive regulation of protein targeting to mitochondrion;positive regulation of protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;protein phosphorylation;regulation of apoptotic process;regulation of autophagy of mitochondrion;regulation of systemic arterial blood pressure;Wnt signaling pathway","ATP binding;protein kinase A catalytic subunit binding;protein serine/threonine kinase activity;receptor binding;tau-protein kinase activity","apical dendrite;beta-catenin destruction complex;cytosol;mitochondrion;neuronal cell body;postsynapse;proximal dendrite","Chemokine signaling pathway;Dopaminergic synapse;Non-alcoholic fatty liver disease (NAFLD)",null,null,8,8,7,"29.4","29.4","27.5","50.98",0,"18.54",140050000,21,"0.304933",1,"-0.44708","-0.748949","sp|P49840|GSK3A_HUMAN;tr|A8MT37|A8MT37_HUMAN;tr|M0QYV0|M0QYV0_HUMAN","sp|P49840|GSK3A_HUMAN;tr|A8MT37|A8MT37_HUMAN;tr|M0QYV0|M0QYV0_HUMAN",1689,"P49840","GSK3A_HUMAN","Glycogen synthase kinase-3 alpha","SK-3 alpha","GSK3A"]
["20.0898","16.2942","15.921","20.3272","16.268","17.0543",{"$nulls":3},"forebrain radial glial cell differentiation;gliogenesis;mRNA catabolic process;mRNA destabilization;mRNA methylation;mRNA splicing, via spliceosome;RNA metabolic process;spermatogenesis;stem cell population maintenance","mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;mRNA binding","nucleoplasm;nucleus;RNA N6-methyladenosine methyltransferase complex",{"$nulls":3},6,6,6,"18.6","18.6","18.6","52.15",0,"21.106",101980000,13,"0.087376",1,"-0.44821","-0.246046","sp|Q9HCE5|MET14_HUMAN;tr|A0A0D9SFW0|A0A0D9SFW0_HUMAN;tr|A0A0D9SF88|A0A0D9SF88_HUMAN;tr|D6RD73|D6RD73_HUMAN;tr|D6RBL4|D6RBL4_HUMAN","sp|Q9HCE5|MET14_HUMAN;tr|A0A0D9SFW0|A0A0D9SFW0_HUMAN",4591,"Q9HCE5","MET14_HUMAN","N6-adenosine-methyltransferase non-catalytic subunit {ECO:0000305}",null,"METTL14"]
["21.7384","19.6955","21.2009","22.1044","20.2395","21.6522",{"$nulls":9},3,3,3,"27.7","27.7","27.7","21.701",0,"11.513",238060000,13,"0.212022",1,"-0.453786","-0.546573","sp|Q3MHD2|LSM12_HUMAN;tr|K7ELG9|K7ELG9_HUMAN","sp|Q3MHD2|LSM12_HUMAN;tr|K7ELG9|K7ELG9_HUMAN",2740,"Q3MHD2","LSM12_HUMAN","Protein LSM12 homolog",null,"LSM12"]
["20.1557","17.3622","18.836","20.1591","18.399","19.1731",{"$nulls":4},"zinc ion binding",{"$nulls":4},7,7,7,"30.8","30.8","30.8","42.542",0,"47.302",117920000,22,"0.18339",1,"-0.459064","-0.481135","tr|H7C0E5|H7C0E5_HUMAN;sp|O75312|ZPR1_HUMAN;tr|H7BZM7|H7BZM7_HUMAN;tr|H7C449|H7C449_HUMAN","tr|H7C0E5|H7C0E5_HUMAN;sp|O75312|ZPR1_HUMAN;tr|H7BZM7|H7BZM7_HUMAN",565,"H7C0E5","H7C0E5_HUMAN",null,null,"ZPR1"]
["20.2264","19.3984","19.8709","21.0407","19.4728","20.3664",{"$nulls":3},"actin cytoskeleton organization;regulation of mitochondrial fission","actin binding;Rho GTPase binding","perinuclear region of cytoplasm",{"$nulls":3},14,14,14,"18.6","18.6","18.6","135.62",0,"184.42",611340000,69,"0.37709",1,"-0.461439","-0.898592","sp|Q27J81|INF2_HUMAN;tr|A0A0A0MQU1|A0A0A0MQU1_HUMAN","sp|Q27J81|INF2_HUMAN;tr|A0A0A0MQU1|A0A0A0MQU1_HUMAN",2712,"Q27J81","INF2_HUMAN","Inverted formin-2",null,"INF2"]
["24.0691","21.9438","23.4386","24.2655","22.6285","23.9527",{"$nulls":3},"activation of MAPK activity;anaphase-promoting complex-dependent catabolic process;animal organ regeneration;apoptotic process;cell aging;cell division;cell migration;cell proliferation;cellular response to hydrogen peroxide;centrosome cycle;chromosome condensation;ciliary basal body-plasma membrane docking;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA repair;DNA replication;epithelial cell differentiation;G2/M transition of mitotic cell cycle;Golgi disassembly;microtubule cytoskeleton organization;mitotic G2 DNA damage checkpoint;mitotic nuclear envelope disassembly;negative regulation of apoptotic process;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of cardiac muscle cell proliferation;positive regulation of DNA replication;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of gene expression;positive regulation of mitochondrial ATP synthesis coupled electron transport;positive regulation of protein import into nucleus, translocation;positive regulation of protein localization to nucleus;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;pronuclear fusion;proteasome-mediated ubiquitin-dependent protein catabolic process;protein complex assembly;protein deubiquitination;protein localization to kinetochore;protein phosphorylation;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of embryonic development;regulation of G2/M transition of mitotic cell cycle;regulation of gene expression;regulation of meiotic cell cycle;regulation of Schwann cell differentiation;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;response to activity;response to amine;response to axon injury;response to cadmium ion;response to copper ion;response to drug;response to ethanol;response to organic cyclic compound;response to toxic substance;transcription initiation from RNA polymerase II promoter;ventricular cardiac muscle cell development","ATP binding;chromatin binding;cyclin binding;cyclin-dependent protein kinase activity;cyclin-dependent protein serine/threonine kinase activity;histone kinase activity;Hsp70 protein binding;protein kinase activity;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity;virus receptor activity","centrosome;cyclin B1-CDK1 complex;cyclin-dependent protein kinase holoenzyme complex;cytosol;endoplasmic reticulum membrane;extracellular exosome;membrane;midbody;mitochondrial matrix;mitochondrion;mitotic spindle;nuclear chromosome, telomeric region;nucleoplasm;nucleus;spindle microtubule","Cell cycle;Cellular senescence;Gap junction;Human immunodeficiency virus 1 infection;Oocyte meiosis;p53 signaling pathway;Progesterone-mediated oocyte maturation;Viral carcinogenesis",null,null,19,19,17,"74.1","74.1","67.7","34.095",0,"159.66",2749800000,192,"0.225745",1,"-0.465076","-0.577351","sp|P06493|CDK1_HUMAN;tr|A0A024QZP7|A0A024QZP7_HUMAN;tr|A0A087WZZ9|A0A087WZZ9_HUMAN;tr|E5RIU6|E5RIU6_HUMAN","sp|P06493|CDK1_HUMAN;tr|A0A024QZP7|A0A024QZP7_HUMAN;tr|A0A087WZZ9|A0A087WZZ9_HUMAN;tr|E5RIU6|E5RIU6_HUMAN",913,"P06493","CDK1_HUMAN","Cyclin-dependent kinase 1","DK1","CDK1"]
["16.8639","14.9807","16.9666","16.9495","15.6417","17.6242",{"$nulls":3},"COPII vesicle coating",null,"cytosol;Golgi membrane;nucleoplasm",{"$nulls":3},5,5,5,"6.9","6.9","6.9","112.96",0,"10.476",42171000,5,"0.208478",1,"-0.468079","-0.538565","sp|O15084|ANR28_HUMAN;tr|B4DIW9|B4DIW9_HUMAN;tr|H7C4A0|H7C4A0_HUMAN;tr|H7C209|H7C209_HUMAN;sp|Q8N8A2|ANR44_HUMAN","sp|O15084|ANR28_HUMAN;tr|B4DIW9|B4DIW9_HUMAN",330,"O15084","ANR28_HUMAN","Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A","erine/threonine-protein phosphatase 6 regulatory subunit ARS-A;P6-ARS-A","ANKRD28"]
["25.3356","23.5317","24.7487","25.6442","23.9736","25.4188",{"$nulls":3},"acetyl-CoA metabolic process;cellular response to interleukin-4;fatty acid biosynthetic process;fatty acid metabolic process;fatty-acyl-CoA biosynthetic process;mammary gland development;osteoblast differentiation;pantothenate metabolic process;positive regulation of cellular metabolic process;regulation of cholesterol biosynthetic process","[acyl-carrier-protein] S-acetyltransferase activity;[acyl-carrier-protein] S-malonyltransferase activity;3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity;3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity;3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity;3-oxoacyl-[acyl-carrier-protein] synthase activity;3-oxo-glutaryl-[acp] methyl ester reductase activity;3-oxo-pimeloyl-[acp] methyl ester reductase activity;cadherin binding;drug binding;enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity;enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity;fatty acid synthase activity;myristoyl-[acyl-carrier-protein] hydrolase activity;NADPH binding;oleoyl-[acyl-carrier-protein] hydrolase activity;palmitoyl-[acyl-carrier-protein] hydrolase activity;phosphopantetheine binding;protein homodimerization activity;RNA binding","cytosol;extracellular exosome;glycogen granule;Golgi apparatus;melanosome;membrane;mitochondrion;plasma membrane","AMPK signaling pathway;Fatty acid biosynthesis;Fatty acid metabolism;Insulin signaling pathway;Metabolic pathways",null,null,109,109,109,"56.9","56.9","56.9","273.42",0,"323.31",42427000000,1189,"0.251854",1,"-0.473522","-0.634983","sp|P49327|FAS_HUMAN;tr|J3KTF0|J3KTF0_HUMAN","sp|P49327|FAS_HUMAN",1650,"P49327","FAS_HUMAN","Fatty acid synthase",null,"FASN"]
["19.2589","18.5065","19.3622","20.5307","18.2507","19.7851",{"$nulls":3},"aggrephagy;antigen processing and presentation of endogenous antigen;apoptotic process;autophagosome assembly;autophagy;autophagy of host cells involved in interaction with symbiont;autophagy of mitochondrion;autophagy of nucleus;blood vessel remodeling;cellular homeostasis;cellular response to nitrogen starvation;cellular response to nitrosative stress;C-terminal protein lipidation;heart contraction;macroautophagy;negative regulation of apoptotic process;negative regulation of cell death;negative regulation of histone H4-K16 acetylation;negative regulation of phagocytosis;negative regulation of protein ubiquitination;negative regulation of reactive oxygen species metabolic process;negative stranded viral RNA replication;negative thymic T cell selection;otolith development;positive regulation of mucus secretion;post-translational protein modification;protein lipidation involved in autophagosome assembly;regulation of cilium assembly;regulation of cytokine secretion involved in immune response;regulation of release of sequestered calcium ion into cytosol;response to drug;response to fungus;vasodilation;ventricular cardiac muscle cell development",null,"Atg12-Atg5-Atg16 complex;autophagosome;axoneme;cytoplasm;cytosol;ER-mitochondrion membrane contact site;membrane;phagocytic vesicle membrane;phagophore assembly site membrane","Autophagy - animal;Autophagy - other;Ferroptosis;Longevity regulating pathway;Longevity regulating pathway - multiple species;Mitophagy - animal;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Shigellosis",null,null,6,6,6,"27.6","27.6","27.6","32.447",0,"27.3",79463000,14,"0.264791",1,"-0.479659","-0.663128","sp|Q9H1Y0|ATG5_HUMAN;tr|L7UQJ2|L7UQJ2_HUMAN","sp|Q9H1Y0|ATG5_HUMAN;tr|L7UQJ2|L7UQJ2_HUMAN",4419,"Q9H1Y0","ATG5_HUMAN","Autophagy protein 5",null,"ATG5"]
["18.7318","18.2162","17.488","19.2785","18.2184","18.3832",{"$nulls":4},"calcium ion binding;ubiquitin binding",{"$nulls":4},10,10,10,20,20,20,"84.72",0,"31.174",210670000,24,"0.419954",1,"-0.481356","-0.985366","tr|Q86YQ0|Q86YQ0_HUMAN;sp|Q96MX6|WDR92_HUMAN;tr|F6U1T9|F6U1T9_HUMAN;sp|P63098|CANB1_HUMAN;tr|D3YTA9|D3YTA9_HUMAN;tr|H7BYZ3|H7BYZ3_HUMAN;tr|Q8ND98|Q8ND98_HUMAN;tr|H7C389|H7C389_HUMAN;sp|Q96LZ3|CANB2_HUMAN","tr|Q86YQ0|Q86YQ0_HUMAN;sp|Q96MX6|WDR92_HUMAN",5618,"Q86YQ0","Q86YQ0_HUMAN",null,null,"HZGJ"]
["19.1633","18.3849","17.6288","19.6125","18.4522","18.5609",{"$nulls":3},"activation of JUN kinase activity;androgen receptor signaling pathway;apoptotic process;cellular response to cadmium ion;cellular response to copper ion;cellular response to diamide;cellular response to heat;cellular response to sodium arsenite;cellular response to unfolded protein;chromatin remodeling;covalent chromatin modification;extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of transcription, DNA-templated;nucleosome assembly;positive regulation of neuron death;positive regulation of protein kinase activity;positive regulation of protein phosphorylation;regulation of protein ubiquitination;regulation of transcription, DNA-templated;transcription, DNA-templated;viral process","androgen receptor binding;enzyme binding;heat shock protein binding;histone binding;p53 binding;protein heterodimerization activity;protein homodimerization activity;protein kinase activator activity;protein kinase binding;protein N-terminus binding;signal transducer activity, downstream of receptor;SUMO binding;transcription coactivator activity;transcription corepressor activity;transcription factor binding;ubiquitin protein ligase binding","chromosome, centromeric region;cytoplasm;cytosol;nuclear body;nucleolus;nucleoplasm;nucleus;PML body;SWI/SNF superfamily-type complex","Amyotrophic lateral sclerosis (ALS);Apoptosis;Herpes simplex virus 1 infection;MAPK signaling pathway",null,null,12,12,12,"26.8","26.8","26.8","81.372",0,"95.657",599050000,67,"0.346926",1,"-0.482879","-0.836658","sp|Q9UER7|DAXX_HUMAN;tr|Q5STR5|Q5STR5_HUMAN;tr|Q4VX54|Q4VX54_HUMAN","sp|Q9UER7|DAXX_HUMAN",4990,"Q9UER7","DAXX_HUMAN","Death domain-associated protein 6",null,"DAXX"]
["19.5556","17.4468","17.6845","19.9663","17.5793","18.6026",{"$nulls":3},"apoptotic process;regulation of apoptotic process;Rho protein signal transduction;septin cytoskeleton organization;signal transduction","GTP binding;GTPase inhibitor activity;GTP-Rho binding","cytosol",{"$nulls":3},8,8,8,"29.3","29.3","29.3","62.667",0,"76.724",218200000,41,"0.194671",1,"-0.487141","-0.507126","sp|Q9BST9|RTKN_HUMAN","sp|Q9BST9|RTKN_HUMAN",4190,"Q9BST9","RTKN_HUMAN","Rhotekin",null,"RTKN"]
["19.0086","16.6623","16.346","19.5198","16.4009","17.5593",{"$nulls":3},"angiotensin maturation;eye pigmentation;head morphogenesis;neutrophil degranulation;positive regulation of transforming growth factor beta1 production;positive regulation of Wnt signaling pathway;regulation of MAPK cascade;rostrocaudal neural tube patterning","enzyme binding;receptor activity","cell body;external side of plasma membrane;extracellular exosome;ficolin-1-rich granule membrane;integral component of membrane;neuron projection;plasma membrane;tertiary granule membrane","Renin-angiotensin system",null,null,4,4,4,"17.4","17.4","17.4","39.008",0,"13.257",28366000,8,"0.146401",1,"-0.487666","-0.393775","sp|O75787|RENR_HUMAN;tr|H7C3E1|H7C3E1_HUMAN;tr|H7C240|H7C240_HUMAN;tr|H0Y750|H0Y750_HUMAN","sp|O75787|RENR_HUMAN;tr|H7C3E1|H7C3E1_HUMAN;tr|H7C240|H7C240_HUMAN;tr|H0Y750|H0Y750_HUMAN",631,"O75787","RENR_HUMAN","Renin receptor",null,"ATP6AP2"]
["18.3045",1,"18.2573","20.0434",1,"17.9904",{"$nulls":3},"peptidyl-diphthamide biosynthetic process from peptidyl-histidine",{"$nulls":5},3,3,3,"21.4","21.4","21.4","27.845",0,"18.974",27291000,7,"0.0195776",1,"-0.490658","-0.0588131","tr|H0YCR5|H0YCR5_HUMAN;sp|Q9BQC3|DPH2_HUMAN","tr|H0YCR5|H0YCR5_HUMAN;sp|Q9BQC3|DPH2_HUMAN",4144,"H0YCR5","H0YCR5_HUMAN",null,null,"DPH2"]
["20.755","19.4435","20.2664","21.5505","19.6393","20.7667",{"$nulls":3},"cell-matrix adhesion;dendritic spine maintenance;exploration behavior;extracellular matrix organization;heart development;integrin-mediated signaling pathway;leukocyte migration;lung development;maternal process involved in female pregnancy;memory;mesodermal cell differentiation;negative regulation of cell projection organization;negative regulation of Rho protein signal transduction;nephron development;neuron migration;positive regulation of cell-substrate adhesion;positive regulation of epithelial cell migration;positive regulation of gene expression;positive regulation of neuron projection development;positive regulation of protein localization to plasma membrane;regulation of BMP signaling pathway;regulation of transforming growth factor beta receptor signaling pathway;regulation of Wnt signaling pathway;renal filtration;response to drug;response to gonadotropin;skin development","collagen binding;fibronectin binding;integrin binding;laminin binding;metal ion binding;protease binding;protein domain specific binding;protein heterodimerization activity","basolateral plasma membrane;cell periphery;cell surface;excitatory synapse;external side of plasma membrane;extracellular exosome;filopodium membrane;focal adhesion;growth cone;integrin alpha3-beta1 complex;integrin complex;invadopodium membrane;perinuclear region of cytoplasm;plasma membrane;receptor complex;synaptic membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Hematopoietic cell lineage;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);Pathways in cancer;PI3K-Akt signaling pathway;Regulation of actin cytoskeleton;Small cell lung cancer",null,null,18,18,18,"20.7","20.7","20.7","116.61",0,"61.985",827720000,54,"0.299663",1,"-0.497194","-0.737802","sp|P26006|ITA3_HUMAN;tr|D6R9X8|D6R9X8_HUMAN;tr|H0YA49|H0YA49_HUMAN;tr|K7EMU3|K7EMU3_HUMAN","sp|P26006|ITA3_HUMAN",1299,"P26006","ITA3_HUMAN","Integrin alpha-3",null,"ITGA3"]
["14.0407","15.1639","15.8686","15.034","15.2283","16.3143",{"$nulls":5},"focal adhesion;integral component of membrane",{"$nulls":3},5,5,5,"3.6","3.6","3.6","200.07",0,"9.3368",34362000,9,"0.307223",1,"-0.501133","-0.753784","sp|Q5VW36|FOCAD_HUMAN;tr|S4R400|S4R400_HUMAN","sp|Q5VW36|FOCAD_HUMAN;tr|S4R400|S4R400_HUMAN",2904,"Q5VW36","FOCAD_HUMAN","Focadhesin",null,"FOCAD"]
["19.9177","19.4407","17.787","21.5204","18.8243","18.3129",{"$nulls":3},"carbohydrate metabolic process;glycerol-3-phosphate catabolic process;NAD metabolic process;NADH metabolic process;negative regulation of peptidyl-serine phosphorylation;negative regulation of protein kinase C signaling;phosphatidic acid biosynthetic process;positive regulation of protein localization to cell surface;positive regulation of sodium ion transport;regulation of heart rate;regulation of sodium ion transmembrane transporter activity;regulation of ventricular cardiac muscle cell membrane depolarization;ventricular cardiac muscle cell action potential","glycerol-3-phosphate dehydrogenase [NAD+] activity;ion channel binding;NAD binding;protein homodimerization activity;sodium channel regulator activity","cytosol;extracellular exosome;glycerol-3-phosphate dehydrogenase complex;plasma membrane","Glycerophospholipid metabolism",null,null,7,7,7,"21.7","21.7","21.7","38.418",0,"25.48",192090000,15,"0.159441",1,"-0.504031","-0.424971","sp|Q8N335|GPD1L_HUMAN;tr|C9K0P5|C9K0P5_HUMAN;tr|C9JFA7|C9JFA7_HUMAN;tr|C9JM46|C9JM46_HUMAN","sp|Q8N335|GPD1L_HUMAN;tr|C9K0P5|C9K0P5_HUMAN;tr|C9JFA7|C9JFA7_HUMAN;tr|C9JM46|C9JM46_HUMAN",3386,"Q8N335","GPD1L_HUMAN","Glycerol-3-phosphate dehydrogenase 1-like protein","PD1-L","GPD1L"]
[1,"15.941","16.713","17.2374",1,"16.9432",{"$nulls":3},"amino acid transport;cognition;glutamine transport;hydroxyproline transport;L-alanine transport;L-cystine transport;L-serine transport;proline transport;synaptic transmission, glutamatergic;threonine transport","amino acid transmembrane transporter activity;chloride channel activity;L-alanine transmembrane transporter activity;L-cystine transmembrane transporter activity;L-glutamine transmembrane transporter activity;L-hydroxyproline transmembrane transporter activity;L-proline transmembrane transporter activity;L-serine transmembrane transporter activity;L-threonine transmembrane transporter activity;symporter activity","cell surface;dendrite;extracellular exosome;integral component of membrane;integral component of plasma membrane;intermediate filament;melanosome;membrane;neuronal cell body;plasma membrane",{"$nulls":3},2,2,2,"7.1","7.1","7.1","55.722",0,"5.6016",28145000,5,"0.0229372",1,"-0.50885","-0.06866","sp|P43007|SATT_HUMAN","sp|P43007|SATT_HUMAN",1564,"P43007","SATT_HUMAN","Neutral amino acid transporter A",null,"SLC1A4"]
["16.4204","15.106","15.1064","18.0623","14.3727","15.7477",{"$nulls":3},"mRNA processing;negative regulation of stem cell differentiation;phosphorylation of RNA polymerase II C-terminal domain;positive regulation of transcription from RNA polymerase II promoter;protein autophosphorylation;regulation of MAP kinase activity;regulation of RNA splicing;RNA splicing;transcription elongation from RNA polymerase II promoter","ATP binding;cyclin binding;cyclin-dependent protein serine/threonine kinase activity;protein kinase activity;protein kinase binding;RNA polymerase II carboxy-terminal domain kinase activity;transcription factor binding;transcription regulatory region DNA binding","chromosome;cyclin K-CDK12 complex;cyclin/CDK positive transcription elongation factor complex;fibrillar center;nuclear cyclin-dependent protein kinase holoenzyme complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},19,18,15,"21.7","21.1","18.3","164.15",0,"108.88",373780000,57,"0.167715",1,"-0.516666","-0.444532","sp|Q9NYV4|CDK12_HUMAN;tr|J3QSD7|J3QSD7_HUMAN;tr|A0A087X209|A0A087X209_HUMAN;tr|Q9BVE2|Q9BVE2_HUMAN;tr|H0YLT2|H0YLT2_HUMAN","sp|Q9NYV4|CDK12_HUMAN;tr|J3QSD7|J3QSD7_HUMAN",4860,"Q9NYV4","CDK12_HUMAN","Cyclin-dependent kinase 12",null,"CDK12"]
["17.0253","16.5737","16.7645","17.6264","16.0556","18.24",{"$nulls":9},4,4,4,"22.6","22.6","22.6","26.432",0,"11.565",110900000,15,"0.321103",1,"-0.519479","-0.782949","tr|B5ME25|B5ME25_HUMAN;sp|Q9H825|METL8_HUMAN;tr|E7ETE0|E7ETE0_HUMAN;tr|B3KW44|B3KW44_HUMAN;tr|C9JE69|C9JE69_HUMAN;tr|C9J3F1|C9J3F1_HUMAN;tr|C9J6U8|C9J6U8_HUMAN;tr|H7C2P8|H7C2P8_HUMAN","tr|B5ME25|B5ME25_HUMAN;sp|Q9H825|METL8_HUMAN;tr|E7ETE0|E7ETE0_HUMAN;tr|B3KW44|B3KW44_HUMAN;tr|C9JE69|C9JE69_HUMAN",4514,"B5ME25","B5ME25_HUMAN",null,null,"METTL8"]
[1,"16.0209","16.9813",1,"16.3074","18.2556",{"$nulls":5},"nucleus",{"$nulls":3},3,3,3,"12.7","12.7","12.7","37.548","0.0004178","4.3558",35278000,3,"0.0231191",1,"-0.520294","-0.069191","sp|Q70Z53|F10C1_HUMAN","sp|Q70Z53|F10C1_HUMAN",3100,"Q70Z53","F10C1_HUMAN","Protein FRA10AC1",null,"FRA10AC1"]
["21.5178","21.5364","20.8276","21.9703","22.0157","21.4572",{"$nulls":9},5,5,5,"71.3","71.3","71.3","14.437",0,"93.946",220790000,30,"0.819804",1,"-0.520453","-1.77009","tr|C9IYL4|C9IYL4_HUMAN;sp|P29083|T2EA_HUMAN","tr|C9IYL4|C9IYL4_HUMAN;sp|P29083|T2EA_HUMAN",1349,"C9IYL4","C9IYL4_HUMAN",null,null,"GTF2E1"]
["19.5561","19.2806","20.0081","20.3684","19.714","20.3683",{"$nulls":9},10,10,10,"23.8","23.8","23.8","57.891",0,"45.203",846190000,54,"0.814502",1,"-0.535269","-1.75962","sp|Q8TBB5|KLDC4_HUMAN;tr|H3BQH3|H3BQH3_HUMAN;tr|H3BV82|H3BV82_HUMAN;tr|Q9UF94|Q9UF94_HUMAN;tr|H3BP99|H3BP99_HUMAN;tr|H3BQ90|H3BQ90_HUMAN","sp|Q8TBB5|KLDC4_HUMAN;tr|H3BQH3|H3BQH3_HUMAN",3542,"Q8TBB5","KLDC4_HUMAN","Kelch domain-containing protein 4",null,"KLHDC4"]
["16.8134","15.2161","15.2834","17.7542","14.956","16.2195",{"$nulls":3},"cytokine production;excretion;positive regulation of transcription from RNA polymerase II promoter;regulation of calcineurin-NFAT signaling cascade;signal transduction;transcription from RNA polymerase II promoter","DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytosol;nucleoplasm;nucleus",{"$nulls":3},5,5,5,5,5,5,"165.76",0,"16.624",46242000,6,"0.217938",1,"-0.538937","-0.559884","sp|O94916|NFAT5_HUMAN","sp|O94916|NFAT5_HUMAN",694,"O94916","NFAT5_HUMAN","Nuclear factor of activated T-cells 5","F-AT5","NFAT5"]
["20.6715","19.4684","20.6131","21.9932","19.5951","20.7888",{"$nulls":3},"intracellular receptor signaling pathway;negative regulation of cell growth;wound healing",null,"cell surface;integral component of plasma membrane",{"$nulls":3},14,14,14,"26.6","26.6","26.6","85.034",0,"99.552",687200000,70,"0.272922",1,"-0.541406","-0.68069","sp|Q96PD2|DCBD2_HUMAN;tr|C9JIW6|C9JIW6_HUMAN","sp|Q96PD2|DCBD2_HUMAN",3992,"Q96PD2","DCBD2_HUMAN","Discoidin, CUB and LCCL domain-containing protein 2",null,"DCBLD2"]
["21.0072","20.4321","22.8353","22.8378","20.444","22.6264",{"$nulls":3},"innate immune response;regulation of phosphorylation","protein phosphatase inhibitor activity","cytoplasm",{"$nulls":3},2,2,2,"34.7","34.7","34.7","15.911",0,"29.961",217950000,22,"0.198895",1,"-0.544543","-0.516786","sp|Q96C90|PP14B_HUMAN","sp|Q96C90|PP14B_HUMAN",3820,"Q96C90","PP14B_HUMAN","Protein phosphatase 1 regulatory subunit 14B",null,"PPP1R14B"]
["16.4417","13.1017","15.7577","17.0413","14.0657","15.8449",{"$nulls":3},"cytoskeleton organization;microtubule cytoskeleton organization;neuron projection development;regulation of cell morphogenesis;regulation of microtubule polymerization","calmodulin binding;microtubule binding;microtubule minus-end binding;spectrin binding","cytoplasm;microtubule",{"$nulls":3},4,4,4,"4.9","4.9","4.9","177.97",0,"14.169",69251000,15,"0.153933",1,"-0.550242","-0.411848","sp|Q5T5Y3|CAMP1_HUMAN","sp|Q5T5Y3|CAMP1_HUMAN",2875,"Q5T5Y3","CAMP1_HUMAN","Calmodulin-regulated spectrin-associated protein 1",null,"CAMSAP1"]
["19.0478","18.5447","18.9127","19.9346","18.7075","19.5322",{"$nulls":4},"ATP binding","endoplasmic reticulum;extracellular exosome;intracellular membrane-bounded organelle",{"$nulls":3},5,5,5,"14.2","14.2","14.2","51.927",0,"15.315",109930000,13,"0.641925",1,"-0.556319","-1.42206","sp|P48723|HSP13_HUMAN","sp|P48723|HSP13_HUMAN",1635,"P48723","HSP13_HUMAN","Heat shock 70 kDa protein 13",null,"HSPA13"]
["20.8446","18.0079","19.1314","20.3884","19.5432","19.7334",{"$nulls":3},"cytokine-mediated signaling pathway;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;gene silencing by RNA;negative regulation of intracellular estrogen receptor signaling pathway;negative regulation of translation;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of ligand-dependent nuclear receptor transcription coactivator activity;positive regulation of peptidyl-serine phosphorylation;regulation of transcription, DNA-templated;sex differentiation;transcription, DNA-templated","epidermal growth factor receptor binding;kinase binding;protein domain specific binding;protein homodimerization activity","CCR4-NOT complex;CCR4-NOT core complex;cytosol;membrane;nucleus;P-body;protein complex","RNA degradation",null,null,7,7,7,"24.7","24.7","24.7","33.631",0,"17.341",166890000,34,"0.258229",1,"-0.560364","-0.648884","sp|Q92600|RCD1_HUMAN;tr|F8WBZ6|F8WBZ6_HUMAN","sp|Q92600|RCD1_HUMAN",3687,"Q92600","CNOT9_HUMAN","CCR4-NOT transcription complex subunit 9 {ECO:0000312|HGNC:HGNC:10445}",null,"CNOT9"]
["19.256","18.6156","19.2646","20.1977","18.574","20.0683",{"$nulls":3},"antigen processing and presentation;phosphatidylinositol biosynthetic process;Rab protein signal transduction;regulation of endocytosis","ATPase activator activity;ATPase binding;GDP binding;GTP binding;GTPase activity;ionotropic glutamate receptor binding;protein transporter activity;syntaxin binding","cytoplasmic vesicle membrane;cytosol;early endosome membrane;endosome;extracellular exosome;insulin-responsive compartment;intracellular membrane-bounded organelle;perinuclear region of cytoplasm;plasma membrane;postsynaptic recycling endosome;recycling endosome membrane;vesicle","Endocytosis",null,null,5,5,4,"30.7","30.7","24.3","24.389",0,"23.133",144830000,15,"0.43105",1,"-0.567912","-1.00763","sp|P20338|RAB4A_HUMAN;tr|A0A087WYT5|A0A087WYT5_HUMAN","sp|P20338|RAB4A_HUMAN",1210,"P20338","RAB4A_HUMAN","Ras-related protein Rab-4A",null,"RAB4A"]
["15.46","15.0712","14.2631","15.9596","15.3755","15.1731",{"$nulls":3},"cellular iron ion homeostasis;erythrocyte homeostasis;intestinal absorption;osteoclast differentiation;post-embryonic development;protoporphyrinogen IX biosynthetic process","4 iron, 4 sulfur cluster binding;iron-responsive element binding;translation repressor activity","cytosol;mitochondrion",{"$nulls":3},3,3,3,"6.5","6.5","6.5","105.06",0,"7.9085",10421000,3,"0.603419",1,"-0.57128","-1.34705","tr|A0A0A6YY96|A0A0A6YY96_HUMAN;sp|P48200|IREB2_HUMAN","tr|A0A0A6YY96|A0A0A6YY96_HUMAN;sp|P48200|IREB2_HUMAN",1623,"A0A0A6YY96","A0A0A6YY96_HUMAN",null,null,"IREB2"]
["18.6836","17.1679","17.1141","18.5997","17.5591","18.5297",{"$nulls":3},"cytoplasmic mRNA processing body assembly;deadenylation-independent decapping of nuclear-transcribed mRNA;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay","identical protein binding;mRNA binding;phosphodiesterase decapping endonuclease activity","cytoplasmic ribonucleoprotein granule;cytosol;membrane;P-body","RNA degradation",null,null,5,5,5,"12.2","12.2","12.2","56.077",0,"14.428",89418000,11,"0.394915",1,"-0.574293","-0.934837","sp|Q96F86|EDC3_HUMAN;tr|H3BPW9|H3BPW9_HUMAN;tr|H3BSQ0|H3BSQ0_HUMAN;tr|H3BQ37|H3BQ37_HUMAN;tr|H3BTD6|H3BTD6_HUMAN;tr|H3BQP5|H3BQP5_HUMAN;tr|H3BU87|H3BU87_HUMAN","sp|Q96F86|EDC3_HUMAN;tr|H3BPW9|H3BPW9_HUMAN",3873,"Q96F86","EDC3_HUMAN","Enhancer of mRNA-decapping protein 3",null,"EDC3"]
["18.266","18.2006","17.901","19.0238","18.5016","18.5715",{"$nulls":3},"actin cytoskeleton reorganization;actomyosin structure organization;cell migration;cytoskeleton organization;establishment or maintenance of cell polarity;intracellular signal transduction;protein phosphorylation;signal transduction","ATP binding;magnesium ion binding;protein kinase activity;protein serine/threonine kinase activity;Rho GTPase binding","actomyosin;cell leading edge;cell-cell junction;cytoplasm;cytoskeleton;extracellular exosome;lamellipodium;plasma membrane",{"$nulls":3},22,19,12,"17.2","15.6","10.9","194.31",0,"62.078",552480000,49,"1.35707",1,"-0.576445","-2.90387","sp|Q9Y5S2|MRCKB_HUMAN","sp|Q9Y5S2|MRCKB_HUMAN",5365,"Q9Y5S2","MRCKB_HUMAN","Serine/threonine-protein kinase MRCK beta",null,"CDC42BPB"]
["22.6784","20.7379","22.51","23.3031","21.4799","22.8751",{"$nulls":3},"cell proliferation in forebrain;deoxyribonucleotide biosynthetic process;DNA replication;male gonad development;mitotic cell cycle;nucleobase-containing small molecule interconversion;protein heterotetramerization;pyrimidine nucleobase metabolic process;response to ionizing radiation;retina development in camera-type eye","ATP binding;disordered domain specific binding;identical protein binding;ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor","cell projection;cytosol;extracellular exosome;neuronal cell body;nuclear envelope;ribonucleoside-diphosphate reductase complex","Drug metabolism - other enzymes;Glutathione metabolism;Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,27,27,27,"45.5","45.5","45.5","90.069",0,"323.31",2791800000,160,"0.279989",1,"-0.577307","-0.695877","sp|P23921|RIR1_HUMAN;tr|E9PL69|E9PL69_HUMAN;tr|E9PP77|E9PP77_HUMAN;tr|H0YCY7|H0YCY7_HUMAN","sp|P23921|RIR1_HUMAN;tr|E9PL69|E9PL69_HUMAN",1276,"P23921","RIR1_HUMAN","Ribonucleoside-diphosphate reductase large subunit",null,"RRM1"]
["17.4057","17.3797","17.0319","18.626","17.1573","17.7944",{"$nulls":3},"cytoplasmic microtubule organization;microtubule nucleation;positive regulation of microtubule polymerization",null,"centrosome;cytosol;microtubule cytoskeleton",{"$nulls":3},5,5,5,"12.9","12.9","12.9","62.543",0,"13.38",63254000,11,"0.59349",1,"-0.586777","-1.32769","sp|Q9P270|SLAI2_HUMAN;tr|D6RIF6|D6RIF6_HUMAN;tr|H0Y9L2|H0Y9L2_HUMAN","sp|Q9P270|SLAI2_HUMAN;tr|D6RIF6|D6RIF6_HUMAN",4925,"Q9P270","SLAI2_HUMAN","SLAIN motif-containing protein 2",null,"SLAIN2"]
["17.321","18.8634","18.0699","18.784","18.1049","19.1258",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity;nuclear retention of pre-mRNA at the site of transcription;poly(A)+ mRNA export from nucleus;positive regulation of B cell differentiation;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of transcription, DNA-templated;posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery;regulation of mRNA stability;spleen development;transcription elongation from RNA polymerase II promoter","double-stranded DNA binding;RNA binding","transcription export complex 2",{"$nulls":3},6,6,6,"20.1","20.1","20.1","46.029",0,"39.418",262340000,34,"0.473792",1,"-0.586789","-1.09276","sp|Q5JVF3|PCID2_HUMAN","sp|Q5JVF3|PCID2_HUMAN",2833,"Q5JVF3","PCID2_HUMAN","PCI domain-containing protein 2",null,"PCID2"]
["20.439","19.3454",1,"21.4309",1,"20.1351",{"$nulls":3},"endocytosis;protein transport",null,"clathrin vesicle coat;clathrin-coated pit;intracellular;plasma membrane",{"$nulls":3},4,4,4,"29.7","29.7","29.7","28.338",0,"17.756",127350000,13,"0.021698",1,"-0.593866","-0.0650357","sp|Q9NVZ3|NECP2_HUMAN;tr|D6RAN6|D6RAN6_HUMAN;tr|F6SKB8|F6SKB8_HUMAN;tr|D6RB24|D6RB24_HUMAN;tr|H0Y970|H0Y970_HUMAN","sp|Q9NVZ3|NECP2_HUMAN;tr|D6RAN6|D6RAN6_HUMAN;tr|F6SKB8|F6SKB8_HUMAN;tr|D6RB24|D6RB24_HUMAN",4781,"Q9NVZ3","NECP2_HUMAN","Adaptin ear-binding coat-associated protein 2",null,"NECAP2"]
["18.0033","17.3917","16.9382","18.7729","17.2018","18.1475",{"$nulls":3},"cell cycle;intracellular signal transduction;peptidyl-serine phosphorylation;positive regulation of inflammatory response;positive regulation of interleukin-6 production;regulation of gene expression;regulation of transcription, DNA-templated;response to osmotic stress;response to stress;transcription, DNA-templated;vascular endothelial growth factor receptor signaling pathway","ATP binding;MAP kinase activity;protein serine/threonine kinase activity","cytoplasm;cytosol;nucleus","Adrenergic signaling in cardiomyocytes;AGE-RAGE signaling pathway in diabetic complications;Amyotrophic lateral sclerosis (ALS);Cellular senescence;Chagas disease (American trypanosomiasis);C-type lectin receptor signaling pathway;Dopaminergic synapse;Endocrine resistance;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;FoxO signaling pathway;GnRH signaling pathway;Hepatitis B;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;IL-17 signaling pathway;Inflammatory mediator regulation of TRP channels;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Leukocyte transendothelial migration;MAPK signaling pathway;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Oocyte meiosis;Osteoclast differentiation;PD-L1 expression and PD-1 checkpoint pathway in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Relaxin signaling pathway;Retrograde endocannabinoid signaling;RIG-I-like receptor signaling pathway;Salmonella infection;Shigellosis;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thermogenesis;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;VEGF signaling pathway;Yersinia infection",null,null,4,4,4,"12.9","12.9","12.9","42.089","0.00081152","3.7932",45734000,3,"0.468331",1,"-0.596328","-1.08193","sp|O15264|MK13_HUMAN;tr|Q5R3E6|Q5R3E6_HUMAN","sp|O15264|MK13_HUMAN",355,"O15264","MK13_HUMAN","Mitogen-activated protein kinase 13","AP kinase 13;APK 13","MAPK13"]
["21.6284","18.0108","20.3296","21.8399","19.2231","20.711",{"$nulls":3},"glucose homeostasis;peptidyl-lysine modification to peptidyl-hypusine;positive regulation of cell proliferation;positive regulation of T cell proliferation;protein homotetramerization;spermidine catabolic process;spermidine metabolic process;translation","deoxyhypusine synthase activity;identical protein binding","cytoplasm;cytosol",{"$nulls":3},10,10,10,"41.7","41.7","41.7","40.97",0,"67.945",345510000,38,"0.175318",1,"-0.601721","-0.46236","sp|P49366|DHYS_HUMAN;tr|A0A087WZK0|A0A087WZK0_HUMAN;tr|Q5J8M5|Q5J8M5_HUMAN;tr|M0R253|M0R253_HUMAN;tr|M0QX43|M0QX43_HUMAN;tr|B4E3M2|B4E3M2_HUMAN;tr|M0R264|M0R264_HUMAN;tr|M0R1T2|M0R1T2_HUMAN;tr|M0R0V2|M0R0V2_HUMAN;tr|M0R1T4|M0R1T4_HUMAN;tr|M0R0J4|M0R0J4_HUMAN;tr|M0QYZ7|M0QYZ7_HUMAN","sp|P49366|DHYS_HUMAN;tr|A0A087WZK0|A0A087WZK0_HUMAN;tr|Q5J8M5|Q5J8M5_HUMAN",1654,"P49366","DHYS_HUMAN","Deoxyhypusine synthase","HS","DHPS"]
["17.7645","18.1595","19.2354","19.0289","18.4824","19.474",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;Golgi vesicle prefusion complex stabilization;protein transport;retrograde transport, vesicle recycling within Golgi;retrograde vesicle-mediated transport, Golgi to ER","identical protein binding","Golgi membrane;Golgi transport complex;trans-Golgi network membrane",{"$nulls":3},12,12,12,"23.7","23.7","23.7","89.082",0,"31.305",184440000,30,"0.507706",1,"-0.608623","-1.15973","sp|Q9H9E3|COG4_HUMAN;tr|A0A0A0MS45|A0A0A0MS45_HUMAN;tr|J3KNI1|J3KNI1_HUMAN;tr|H3BSD2|H3BSD2_HUMAN;tr|H3BQB2|H3BQB2_HUMAN;tr|H3BMV9|H3BMV9_HUMAN;tr|J3QLW1|J3QLW1_HUMAN;tr|E9PRT5|E9PRT5_HUMAN;tr|J3KRB5|J3KRB5_HUMAN","sp|Q9H9E3|COG4_HUMAN;tr|A0A0A0MS45|A0A0A0MS45_HUMAN;tr|J3KNI1|J3KNI1_HUMAN",4542,"Q9H9E3","COG4_HUMAN","Conserved oligomeric Golgi complex subunit 4","OG complex subunit 4","COG4"]
["19.7052","19.7723","20.1986","20.6083","20.6839","20.2138",{"$nulls":3},"DNA biosynthetic process;DNA metabolic process;nucleobase-containing compound metabolic process;protein homotetramerization;pyrimidine nucleoside salvage;thymidine metabolic process","ATP binding;identical protein binding;nucleoside kinase activity;thymidine kinase activity;zinc ion binding","cytosol","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,6,6,6,"34.2","34.2","34.2","25.468",0,"20.934",197160000,17,"1.34323",1,"-0.609994","-2.87214","sp|P04183|KITH_HUMAN;tr|K7ES52|K7ES52_HUMAN;tr|K7ERJ1|K7ERJ1_HUMAN;tr|K7ERV3|K7ERV3_HUMAN;tr|K7ENW5|K7ENW5_HUMAN","sp|P04183|KITH_HUMAN;tr|K7ES52|K7ES52_HUMAN;tr|K7ERJ1|K7ERJ1_HUMAN;tr|K7ERV3|K7ERV3_HUMAN;tr|K7ENW5|K7ENW5_HUMAN",870,"P04183","KITH_HUMAN","Thymidine kinase, cytosolic",null,"TK1"]
["20.2047","16.5574","19.5784","21.0763","17.2604","19.8374",{"$nulls":3},"cellular protein catabolic process;protein K48-linked ubiquitination;protein K63-linked ubiquitination;protein ubiquitination;ubiquitin-dependent protein catabolic process","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome","Parkinson disease;Protein processing in endoplasmic reticulum;Ubiquitin mediated proteolysis",null,null,4,4,4,"28.8","28.8","28.8","19.509",0,"19.569",76104000,12,"0.142425",1,"-0.611175","-0.38417","sp|P62253|UB2G1_HUMAN;tr|I3L0Q0|I3L0Q0_HUMAN;tr|I3L2Q4|I3L2Q4_HUMAN;tr|K7EPR7|K7EPR7_HUMAN;tr|I3L2H7|I3L2H7_HUMAN","sp|P62253|UB2G1_HUMAN;tr|I3L0Q0|I3L0Q0_HUMAN;tr|I3L2Q4|I3L2Q4_HUMAN;tr|K7EPR7|K7EPR7_HUMAN;tr|I3L2H7|I3L2H7_HUMAN",1962,"P62253","UB2G1_HUMAN","Ubiquitin-conjugating enzyme E2 G1",null,"UBE2G1"]
["21.5725","20.0891","21.568","22.5686","20.6569","21.8821",{"$nulls":3},"cellular response to UV;mitotic cell cycle;negative regulation of inflammatory response;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of stress-activated MAPK cascade","ATP binding;protein serine/threonine kinase activity","nucleus",{"$nulls":3},13,13,13,"57.5","57.5","57.5","36.085",0,"71.531",527390000,35,"0.348196",1,"-0.626009","-0.839282","sp|Q96KB5|TOPK_HUMAN;tr|E5RFX4|E5RFX4_HUMAN;tr|E5RIE1|E5RIE1_HUMAN","sp|Q96KB5|TOPK_HUMAN;tr|E5RFX4|E5RFX4_HUMAN",3956,"Q96KB5","TOPK_HUMAN","Lymphokine-activated killer T-cell-originated protein kinase",null,"PBK"]
["18.3172","16.5572","17.0597","18.8682","17.0452","17.9267",{"$nulls":3},"apoptotic process;endosome organization;positive regulation of autophagy;positive regulation of intrinsic apoptotic signaling pathway;protein localization to plasma membrane;vesicle organization","metal ion binding;phosphatidylinositol-3-phosphate binding;phosphatidylinositol-4-phosphate binding;phosphatidylinositol-5-phosphate binding","endosome membrane;lysosomal membrane;lysosome;nucleus;perinuclear region of cytoplasm",{"$nulls":3},5,5,5,"27.6","27.6","27.6","31.194",0,"29.082",174810000,21,"0.356256",1,"-0.635333","-0.8559","sp|Q96S99|PKHF1_HUMAN;tr|K7ELB8|K7ELB8_HUMAN;tr|K7EIX0|K7EIX0_HUMAN","sp|Q96S99|PKHF1_HUMAN;tr|K7ELB8|K7ELB8_HUMAN",4036,"Q96S99","PKHF1_HUMAN","Pleckstrin homology domain-containing family F member 1","H domain-containing family F member 1","PLEKHF1"]
["15.4083","16.6064",1,"17.8801","16.0499",1,{"$nulls":3},"cellular copper ion homeostasis;cytoplasmic sequestering of NF-kappaB;Golgi to plasma membrane transport;negative regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;post-translational protein modification;protein transport;protein ubiquitination","cullin family protein binding","cytosol;endosome;nucleoplasm",{"$nulls":3},5,5,5,"10.8","10.8","10.8","70.755",0,"13.366",32938000,5,"0.0292874",1,"-0.638441","-0.0870881","sp|O60826|CCD22_HUMAN","sp|O60826|CCD22_HUMAN",526,"O60826","CCD22_HUMAN","Coiled-coil domain-containing protein 22",null,"CCDC22"]
["22.4993","23.1959","24.5353","24.08","23.6349","24.466",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},7,7,7,"58.8","58.8","58.8","12.656",0,"66.417",1298900000,62,"0.432068",1,"-0.650122","-1.00967","tr|E5RI99|E5RI99_HUMAN;sp|P62888|RL30_HUMAN;tr|A0A0B4J213|A0A0B4J213_HUMAN;tr|E5RJH3|E5RJH3_HUMAN;tr|A0A0C4DH44|A0A0C4DH44_HUMAN","tr|E5RI99|E5RI99_HUMAN;sp|P62888|RL30_HUMAN",2005,"E5RI99","E5RI99_HUMAN",null,null,"RPL30"]
["19.8568","19.3417","17.5599","19.5855","19.488","19.6525",{"$nulls":3},"mitochondrial tRNA methylation","tRNA (guanine(37)-N(1))-methyltransferase activity","mitochondrial matrix;nucleus",{"$nulls":3},7,7,7,"15.5","15.5","15.5","58.246",0,"22.854",240680000,23,"0.397613",1,"-0.655858","-0.940302","sp|Q32P41|TRM5_HUMAN;tr|G3V494|G3V494_HUMAN;tr|G3V5X1|G3V5X1_HUMAN","sp|Q32P41|TRM5_HUMAN",2732,"Q32P41","TRM5_HUMAN","tRNA (guanine(37)-N1)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03152}",null,"TRMT5"]
["18.9272","19.5513","20.2053","20.4276","20.0558","20.1796",{"$nulls":3},"chromatin remodeling;chromatin silencing;DNA repair;histone deacetylation;histone H2A acetylation;histone H4 acetylation;positive regulation of striated muscle cell differentiation;positive regulation of transcription from RNA polymerase II promoter;regulation of growth;transcription, DNA-templated",null,"NuA4 histone acetyltransferase complex;nucleolus;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},11,11,9,"41.3","41.3","32.6","32.307",0,"69.14",465990000,37,"0.791491",1,"-0.659722","-1.7143","sp|Q15014|MO4L2_HUMAN;tr|Q5JXX1|Q5JXX1_HUMAN;tr|Q5JXX2|Q5JXX2_HUMAN;tr|A0A0A0MT59|A0A0A0MT59_HUMAN;tr|Q5JXX6|Q5JXX6_HUMAN","sp|Q15014|MO4L2_HUMAN;tr|Q5JXX1|Q5JXX1_HUMAN;tr|Q5JXX2|Q5JXX2_HUMAN;tr|A0A0A0MT59|A0A0A0MT59_HUMAN",2535,"Q15014","MO4L2_HUMAN","Mortality factor 4-like protein 2",null,"MORF4L2"]
["20.6461","18.657","21.2698","20.8554","20.1769","21.5573",{"$nulls":3},"intracellular protein transport;vesicle-mediated transport",null,"clathrin adaptor complex",{"$nulls":3},11,11,9,"39.6","39.6","34.5","40.296",0,"31.642",417860000,30,"0.310847",1,"-0.672246","-0.761419","tr|K7EJL1|K7EJL1_HUMAN;sp|Q9BXS5|AP1M1_HUMAN;tr|E7ENJ6|E7ENJ6_HUMAN;tr|K7EQX3|K7EQX3_HUMAN;tr|A0A087WZX7|A0A087WZX7_HUMAN;tr|K7EPJ8|K7EPJ8_HUMAN;tr|K7ENA7|K7ENA7_HUMAN","tr|K7EJL1|K7EJL1_HUMAN;sp|Q9BXS5|AP1M1_HUMAN;tr|E7ENJ6|E7ENJ6_HUMAN",4298,"K7EJL1","K7EJL1_HUMAN",null,null,"AP1M1"]
["16.4716","15.36","18.6295","17.7095","16.3584","18.4393",{"$nulls":3},"endoplasmic reticulum mannose trimming;negative regulation of retrograde protein transport, ER to cytosol;protein retention in ER lumen;protein targeting;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;response to endoplasmic reticulum stress;transmembrane transport;ubiquitin-dependent ERAD pathway","carbohydrate binding;protease binding","endoplasmic reticulum lumen;endoplasmic reticulum membrane;endoplasmic reticulum quality control compartment;Hrd1p ubiquitin ligase complex","Protein processing in endoplasmic reticulum",null,null,5,5,5,"11.5","11.5","11.5","75.561",0,"13.572",69217000,7,"0.235863",1,"-0.682011","-0.599823","sp|Q13438|OS9_HUMAN;tr|B4E321|B4E321_HUMAN;tr|F8W0R2|F8W0R2_HUMAN;tr|F8W1N0|F8W1N0_HUMAN;tr|F8VZI7|F8VZI7_HUMAN;tr|F8W1V2|F8W1V2_HUMAN","sp|Q13438|OS9_HUMAN;tr|B4E321|B4E321_HUMAN",2357,"Q13438","OS9_HUMAN","Protein OS-9",null,"OS9"]
["24.9644","24.5776","22.2481","25.0285","24.4543","24.3929",{"$nulls":3},"cell redox homeostasis","electron transfer activity;protein disulfide oxidoreductase activity","cytoplasm;extracellular exosome;nuclear body",{"$nulls":3},4,4,4,"67.7","67.7","67.7","10.438",0,"64.892",870600000,14,"0.327863",1,"-0.695164","-0.797077","sp|Q9H299|SH3L3_HUMAN;tr|A0A087WV23|A0A087WV23_HUMAN;tr|Q5T123|Q5T123_HUMAN","sp|Q9H299|SH3L3_HUMAN;tr|A0A087WV23|A0A087WV23_HUMAN;tr|Q5T123|Q5T123_HUMAN",4425,"Q9H299","SH3L3_HUMAN","SH3 domain-binding glutamic acid-rich-like protein 3",null,"SH3BGRL3"]
["19.5264","19.1011","19.0684","19.8394","19.8109","20.1456",{"$nulls":3},"establishment of cell polarity;microtubule cytoskeleton organization","ATP binding;protein serine/threonine kinase activity",{"$nulls":4},12,12,11,"24.3","24.3",23,"78.452",0,"59.174",508270000,52,"1.73357",1,"-0.699965","-3.83944","tr|E7ETY4|E7ETY4_HUMAN;tr|E9PC69|E9PC69_HUMAN;sp|Q7KZI7|MARK2_HUMAN;tr|F5H6N2|F5H6N2_HUMAN;tr|F5H4F6|F5H4F6_HUMAN;tr|K7EK17|K7EK17_HUMAN;tr|K7EKG8|K7EKG8_HUMAN;tr|F5H4J8|F5H4J8_HUMAN;tr|H0YKJ3|H0YKJ3_HUMAN;tr|H0YNV4|H0YNV4_HUMAN;sp|Q96L34|MARK4_HUMAN;tr|B4DIB3|B4DIB3_HUMAN;sp|Q9P0L2|MARK1_HUMAN;tr|A0A087X0I6|A0A087X0I6_HUMAN","tr|E7ETY4|E7ETY4_HUMAN;tr|E9PC69|E9PC69_HUMAN;sp|Q7KZI7|MARK2_HUMAN",5504,"E7ETY4","E7ETY4_HUMAN","Non-specific serine/threonine protein kinase {ECO:0000256|SAAS:SAAS00804148}",null,"MARK2"]
["18.5469","13.562","19.6244","20.298","13.3396","20.2118",{"$nulls":3},"intracellular protein transport","Ran GTPase binding","nucleus",{"$nulls":3},13,9,9,"23.4","18.5","18.5","86.54",0,"33.189",210600000,25,"0.0842065",1,"-0.705364","-0.237764","tr|A0A075B780|A0A075B780_HUMAN;sp|O14787|TNPO2_HUMAN;tr|K7ESC1|K7ESC1_HUMAN;tr|K7ENW1|K7ENW1_HUMAN;tr|K7EMA3|K7EMA3_HUMAN","tr|A0A075B780|A0A075B780_HUMAN;sp|O14787|TNPO2_HUMAN",296,"A0A075B780","A0A075B780_HUMAN",null,null,"TNPO2"]
["21.2239","20.6983","20.3613","22.2155","20.8406","21.3591",{"$nulls":4},"flavin adenine dinucleotide binding;oxidoreductase activity, acting on CH-OH group of donors",{"$nulls":4},10,10,10,"31.6","31.6","31.6","49.436",0,"31.382",698790000,54,"0.683159",1,"-0.710571","-1.50238","tr|Q3LIE7|Q3LIE7_HUMAN;sp|Q15392|DHC24_HUMAN;tr|H7C4B7|H7C4B7_HUMAN","tr|Q3LIE7|Q3LIE7_HUMAN;sp|Q15392|DHC24_HUMAN",2594,"Q3LIE7","Q3LIE7_HUMAN",null,null,"Nbla03646"]
["17.7549","16.1659","17.4582","19.2088","16.509","17.8191",{"$nulls":3},"cell surface receptor signaling pathway;cellular response to DNA damage stimulus;cellular response to epidermal growth factor stimulus;cellular response to nerve growth factor stimulus;cellular response to oxygen-glucose deprivation;cellular response to platelet-derived growth factor stimulus;entry of bacterium into host cell;epidermal growth factor receptor signaling pathway;fibroblast growth factor receptor signaling pathway;male gonad development;mast cell degranulation;membrane organization;negative regulation of apoptotic process;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of epidermal growth factor-activated receptor activity;negative regulation of neuron death;neuron death;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of phosphatidylinositol 3-kinase signaling;positive regulation of receptor-mediated endocytosis;protein monoubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;response to activity;response to antibiotic;response to ethanol;response to gamma radiation;response to starvation;response to testosterone;transforming growth factor beta receptor signaling pathway","cadherin binding;calcium ion binding;DNA binding transcription factor activity;ephrin receptor binding;epidermal growth factor receptor binding;phosphatidylinositol 3-kinase regulatory subunit binding;phosphotyrosine residue binding;receptor tyrosine kinase binding;SH3 domain binding;signal transducer activity;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","axon;cytosol;flotillin complex;focal adhesion;growth cone;mast cell granule;membrane raft;nucleus;perinuclear region of cytoplasm;plasma membrane","Bacterial invasion of epithelial cells;Chronic myeloid leukemia;Endocytosis;ErbB signaling pathway;Insulin signaling pathway;Pathways in cancer;Proteoglycans in cancer;Ubiquitin mediated proteolysis",null,null,5,5,5,"7.6","7.6","7.6","99.632",0,"12.739",86199000,8,"0.320784",1,"-0.719327","-0.78228","sp|P22681|CBL_HUMAN","sp|P22681|CBL_HUMAN",1250,"P22681","CBL_HUMAN","E3 ubiquitin-protein ligase CBL",null,"CBL"]
["16.9003","14.5269","15.6129","17.842","15.0076","16.3748",{"$nulls":3},"glomerular visceral epithelial cell migration;hematopoietic progenitor cell differentiation;mitotic cytokinesis;positive regulation of bleb assembly;regulation of exit from mitosis;septin ring assembly","actin binding;cadherin binding","actin cytoskeleton;actomyosin contractile ring;bleb;cell cortex region;nucleoplasm",{"$nulls":3},5,5,5,"5.7","5.7","5.7","124.2",0,"20.061",76751000,16,"0.273458",1,"-0.728107","-0.681845","sp|Q9NQW6|ANLN_HUMAN;tr|H7C1C2|H7C1C2_HUMAN;tr|H7C1K5|H7C1K5_HUMAN","sp|Q9NQW6|ANLN_HUMAN",4666,"Q9NQW6","ANLN_HUMAN","Anillin",null,"ANLN"]
["22.4881","19.6938","21.9316","22.9735","21.7538","21.5858",{"$nulls":3},"mRNA splicing, via spliceosome;protein folding","disordered domain specific binding;peptidyl-prolyl cis-trans isomerase activity","catalytic step 2 spliceosome;extracellular exosome;nucleoplasm","Spliceosome",null,null,5,5,5,50,50,50,"18.237",0,"52.462",404730000,35,"0.312172",1,"-0.733175","-0.764207","sp|Q9Y3C6|PPIL1_HUMAN","sp|Q9Y3C6|PPIL1_HUMAN",5289,"Q9Y3C6","PPIL1_HUMAN","Peptidyl-prolyl cis-trans isomerase-like 1","PIase","PPIL1"]
["17.54","16.2553","17.3308","18.584","16.5477","18.2187",{"$nulls":3},"brain development;embryonic brain development;neuron projection development;positive regulation of interleukin-6 production;regulation of inflammatory response;regulation of tumor necrosis factor production;retrograde transport, endosome to Golgi;vesicle-mediated transport",null,"cytosol;Golgi apparatus;trans-Golgi network;WASH complex",{"$nulls":3},6,6,6,"12.6","12.6","12.6","78.321",0,"9.8944",59593000,8,"0.426517",1,"-0.741398","-0.998542","sp|Q9NUY8|TBC23_HUMAN;tr|C9IZ32|C9IZ32_HUMAN;tr|E9PGE5|E9PGE5_HUMAN;tr|C9JAM5|C9JAM5_HUMAN","sp|Q9NUY8|TBC23_HUMAN;tr|C9IZ32|C9IZ32_HUMAN;tr|E9PGE5|E9PGE5_HUMAN",4746,"Q9NUY8","TBC23_HUMAN","TBC1 domain family member 23",null,"TBC1D23"]
["21.2729","19.6943","19.6336","21.9966","20.533","20.314",{"$nulls":4},"actin binding;receptor binding","cytosol;nucleus;plasma membrane",{"$nulls":3},33,33,33,"37.3","37.3","37.3","136.14",0,"201.38",1210300000,104,"0.423713",1,"-0.747596","-0.992917","tr|E9PHV5|E9PHV5_HUMAN;sp|P28290|SSFA2_HUMAN;tr|E7EUL7|E7EUL7_HUMAN;tr|H7BZ26|H7BZ26_HUMAN","tr|E9PHV5|E9PHV5_HUMAN;sp|P28290|SSFA2_HUMAN;tr|E7EUL7|E7EUL7_HUMAN",1338,"E9PHV5","E9PHV5_HUMAN",null,null,"SSFA2"]
["19.463","18.5876","20.0471","20.8987","18.7951","20.6573",{"$nulls":3},"DNA replication initiation;DNA replication, synthesis of RNA primer;G1/S transition of mitotic cell cycle;telomere maintenance via semi-conservative replication","DNA primase activity;metal ion binding;single-stranded DNA binding","alpha DNA polymerase:primase complex;membrane;nucleoplasm","DNA replication",null,null,12,12,12,"35.2","35.2","35.2","49.901",0,"61.692",369460000,41,"0.403746",1,"-0.751116","-0.952707","sp|P49642|PRI1_HUMAN;tr|F8VNY2|F8VNY2_HUMAN;tr|F8VSB2|F8VSB2_HUMAN;tr|H0YIP2|H0YIP2_HUMAN","sp|P49642|PRI1_HUMAN;tr|F8VNY2|F8VNY2_HUMAN",1670,"P49642","PRI1_HUMAN","DNA primase small subunit",null,"PRIM1"]
["15.8425","14.6522","16.1888","17.9562","14.8324","16.1678",{"$nulls":9},5,5,5,"9.9","9.9","9.9","74.789",0,"6.4226",29673000,6,"0.302859",1,"-0.75765","-0.744566","tr|H0Y6I6|H0Y6I6_HUMAN;sp|Q96ME1|FXL18_HUMAN","tr|H0Y6I6|H0Y6I6_HUMAN;sp|Q96ME1|FXL18_HUMAN",3974,"H0Y6I6","H0Y6I6_HUMAN",null,null,"FBXL18"]
["18.1395","18.3534","17.4347","19.7411","18.2749","18.2088",{"$nulls":4},"calcium ion binding","extracellular exosome;membrane",{"$nulls":3},4,4,4,"21.2","21.2","21.2","22.313",0,"8.7634",73327000,7,"0.599196",1,"-0.765745","-1.33881","sp|P37235|HPCL1_HUMAN;tr|E9PC71|E9PC71_HUMAN;sp|P84074|HPCA_HUMAN;sp|P61601|NCALD_HUMAN;tr|C9JW46|C9JW46_HUMAN;tr|H7BZC1|H7BZC1_HUMAN;tr|E5RGA9|E5RGA9_HUMAN","sp|P37235|HPCL1_HUMAN;tr|E9PC71|E9PC71_HUMAN;sp|P84074|HPCA_HUMAN;sp|P61601|NCALD_HUMAN",1495,"P37235","HPCL1_HUMAN","Hippocalcin-like protein 1",null,"HPCAL1"]
["17.0346","15.8579","18.0049","17.8271","17.3841","18.0078",{"$nulls":3},"receptor-mediated endocytosis;vesicle docking involved in exocytosis",null,"cytosol;endosome;endosome membrane;trans-Golgi network membrane;transport vesicle",{"$nulls":3},2,2,2,"7.8","7.8","7.8","40.564",0,"7.1951",32620000,6,"0.525443",1,"-0.773876","-1.1946","sp|Q7Z6M1|RABEK_HUMAN;tr|Q5T1S5|Q5T1S5_HUMAN","sp|Q7Z6M1|RABEK_HUMAN;tr|Q5T1S5|Q5T1S5_HUMAN",3186,"Q7Z6M1","RABEK_HUMAN","Rab9 effector protein with kelch motifs",null,"RABEPK"]
["20.5588","16.8945","19.2629","20.6437","18.6066","19.8016",{"$nulls":3},"negative regulation of transport;regulation of translational fidelity;tRNA threonylcarbamoyladenosine modification","double-stranded RNA binding;nucleotidyltransferase activity;tRNA binding","cytoplasm;membrane;mitochondrion",{"$nulls":3},6,6,6,"30.1","30.1","30.1","29.328",0,"16.49",91862000,11,"0.252162",1,"-0.77855","-0.635655","sp|Q86U90|YRDC_HUMAN","sp|Q86U90|YRDC_HUMAN",3215,"Q86U90","YRDC_HUMAN","YrdC domain-containing protein, mitochondrial",null,"YRDC"]
["17.3477","16.6246","17.5573","18.7104","17.1298","18.0547",{"$nulls":3},"positive regulation of protein serine/threonine kinase activity;positive regulation of TORC1 signaling;positive regulation of TORC2 signaling;protein stabilization;regulation of TOR signaling","Hsp90 protein binding;protein complex binding;protein complex scaffold activity;protein kinase binding","chromosome, telomeric region;cytoplasm;cytosol;intracellular;membrane;nuclear body;nuclear periphery;nucleus;TORC1 complex;TORC2 complex","Fanconi anemia pathway;mTOR signaling pathway",null,null,9,9,9,"18.3","18.3","18.3","91.746",0,"39.828",84637000,10,"0.663448",1,"-0.788432","-1.46398","sp|Q9Y4R8|TELO2_HUMAN;tr|H3BRS3|H3BRS3_HUMAN;tr|H3BU45|H3BU45_HUMAN","sp|Q9Y4R8|TELO2_HUMAN;tr|H3BRS3|H3BRS3_HUMAN",5333,"Q9Y4R8","TELO2_HUMAN","Telomere length regulation protein TEL2 homolog",null,"TELO2"]
["17.5931","18.0535","17.4808","18.6205","18.4426","18.441",{"$nulls":3},"cellular response to nerve growth factor stimulus;ciliary basal body-plasma membrane docking;circadian regulation of gene expression;COPII vesicle coating;endocytosis;G2/M transition of mitotic cell cycle;Golgi organization;microtubule nucleation;non-motile cilium assembly;peptidyl-serine phosphorylation;positive regulation of canonical Wnt signaling pathway;positive regulation of non-canonical Wnt signaling pathway;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein phosphorylation;positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation;protein localization to centrosome;protein localization to cilium;protein localization to Golgi apparatus;protein phosphorylation;regulation of cell shape;regulation of circadian rhythm;regulation of G2/M transition of mitotic cell cycle;rRNA processing;spindle assembly;Wnt signaling pathway","ATP binding;cadherin binding;peptide binding;protein kinase activity;protein serine/threonine kinase activity;tau-protein kinase activity","centrosome;cytosol;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus;Golgi membrane;neuron projection;nucleoplasm;nucleus;perinuclear region of cytoplasm;plasma membrane;spindle;spindle microtubule","Circadian rhythm;Gap junction;Hedgehog signaling pathway;Hippo signaling pathway",null,null,5,5,2,"19.5","19.5","10.6","47.33",0,"12.577",172560000,14,"1.89155",1,"-0.792215","-4.28108","sp|P48730|KC1D_HUMAN;tr|H7BYT1|H7BYT1_HUMAN;tr|H0Y645|H0Y645_HUMAN;tr|B0QY35|B0QY35_HUMAN;tr|B0QY34|B0QY34_HUMAN;tr|J3QQI9|J3QQI9_HUMAN;tr|B0QY36|B0QY36_HUMAN;tr|J3KRM8|J3KRM8_HUMAN;tr|H0Y2N6|H0Y2N6_HUMAN","sp|P48730|KC1D_HUMAN;tr|H7BYT1|H7BYT1_HUMAN;tr|H0Y645|H0Y645_HUMAN;tr|B0QY35|B0QY35_HUMAN;tr|B0QY34|B0QY34_HUMAN",1637,"P48730","KC1D_HUMAN","Casein kinase I isoform delta","KId;KI-delta","CSNK1D"]
["21.0239","21.0274","20.7391","23.3952","20.4795","21.2996",{"$nulls":3},"negative regulation of phosphatase activity;protein complex assembly;rRNA metabolic process;rRNA transcription","RNA binding","condensed nuclear chromosome;cytoplasm;nucleolus;nucleoplasm",{"$nulls":3},15,15,15,"59.4","59.4","59.4","34.222",0,"323.31",3130100000,128,"0.382605",1,"-0.794611","-0.909832","sp|Q9BYG3|MK67I_HUMAN;tr|C9J808|C9J808_HUMAN;tr|H7BZL0|H7BZL0_HUMAN;tr|C9J6C5|C9J6C5_HUMAN","sp|Q9BYG3|MK67I_HUMAN;tr|C9J808|C9J808_HUMAN",4314,"Q9BYG3","MK67I_HUMAN","MKI67 FHA domain-interacting nucleolar phosphoprotein",null,"NIFK"]
["16.996","15.3212","17.2674","17.8402","15.7624","18.3885",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);positive regulation of rRNA processing;positive regulation of transcription from RNA polymerase I promoter;rRNA processing;transcription, DNA-templated","RNA binding;snoRNA binding","90S preribosome;fibrillar center;membrane;mitochondrion;nucleolus;nucleoplasm;small-subunit processome;t-UTP complex","Ribosome biogenesis in eukaryotes",null,null,14,14,14,"9.8","9.8","9.8","242.37",0,"30.317",169790000,25,"0.328393",1,"-0.802182","-0.798181","sp|Q9H583|HEAT1_HUMAN;tr|Q5T3Q7|Q5T3Q7_HUMAN","sp|Q9H583|HEAT1_HUMAN;tr|Q5T3Q7|Q5T3Q7_HUMAN",4478,"Q9H583","HEAT1_HUMAN","HEAT repeat-containing protein 1",null,"HEATR1"]
["18.3835","15.6728","16.9113","18.5953","16.8879","17.925",{"$nulls":3},"glycogen catabolic process;glycophagy;intracellular transport;neutrophil degranulation","enzyme binding;glycogen binding;polysaccharide binding;starch binding","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;ficolin-1-rich granule membrane;integral component of plasma membrane;intracellular;membrane;perinuclear region of cytoplasm;phagophore assembly site membrane;plasma membrane;tertiary granule membrane;T-tubule",{"$nulls":3},3,3,3,"12.6","12.6","12.6","39.007",0,"9.3681",54564000,9,"0.366503",1,"-0.813495","-0.876944","sp|O95210|STBD1_HUMAN","sp|O95210|STBD1_HUMAN",723,"O95210","STBD1_HUMAN","Starch-binding domain-containing protein 1 {ECO:0000303|PubMed:20810658}",null,"STBD1"]
["20.2278","17.9098","18.0379","21.0172","18.009","19.6043",{"$nulls":3},"embryonic organ development;endocytosis;female pregnancy;in utero embryonic development;membrane organization;negative regulation of epidermal growth factor receptor signaling pathway;Notch signaling pathway","lipid binding","clathrin-coated pit;cytosol;nucleus;plasma membrane","Endocytosis",null,null,6,6,6,"14.9","14.9","14.9","60.293",0,"21.673",130060000,20,"0.287542",1,"-0.818324","-0.712031","sp|Q9Y6I3|EPN1_HUMAN;tr|D6R907|D6R907_HUMAN;tr|D6RBI9|D6RBI9_HUMAN;tr|D6RBR6|D6RBR6_HUMAN;tr|D6RFG3|D6RFG3_HUMAN;tr|D6REL6|D6REL6_HUMAN;tr|I6L9I8|I6L9I8_HUMAN;sp|Q9H201|EPN3_HUMAN","sp|Q9Y6I3|EPN1_HUMAN",5409,"Q9Y6I3","EPN1_HUMAN","Epsin-1",null,"EPN1"]
["14.4803",1,"14.9339","15.6441",1,"16.2615",{"$nulls":3},"ion transport",null,"integral component of membrane;membrane;plasma membrane",{"$nulls":3},2,2,2,"6.4","6.4","6.4","76.118","0.00081202","3.8164",9225600,3,"0.0418083",1,"-0.830464","-0.122756","sp|Q8NE01|CNNM3_HUMAN","sp|Q8NE01|CNNM3_HUMAN",3485,"Q8NE01","CNNM3_HUMAN","Metal transporter CNNM3",null,"CNNM3"]
["18.6193","16.9613","19.1048","20.1956","18.0834","18.9724",{"$nulls":3},"cell division;mitotic chromosome condensation",null,"condensed chromosome, centromeric region;condensin complex;cytoplasm;cytosol;membrane;nucleus",{"$nulls":3},7,7,6,"10.2","10.2","8.7","114.33",0,"43.002",212100000,24,"0.406724",1,"-0.855336","-0.958721","sp|Q9BPX3|CND3_HUMAN;tr|D6RA93|D6RA93_HUMAN","sp|Q9BPX3|CND3_HUMAN",4128,"Q9BPX3","CND3_HUMAN","Condensin complex subunit 3",null,"NCAPG"]
["23.8283","23.1266","23.7999","24.7846","24.0242","24.5442",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal large subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome;tRNA binding","cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;membrane","Ribosome",null,null,9,9,9,40,40,40,"12.538",0,"20.96",1906700000,113,"1.26654",1,"-0.866067","-2.69932","sp|P18077|RL35A_HUMAN;tr|C9K025|C9K025_HUMAN;tr|F8WBS5|F8WBS5_HUMAN;tr|F8WB72|F8WB72_HUMAN","sp|P18077|RL35A_HUMAN;tr|C9K025|C9K025_HUMAN;tr|F8WBS5|F8WBS5_HUMAN;tr|F8WB72|F8WB72_HUMAN",1172,"P18077","RL35A_HUMAN","60S ribosomal protein L35a",null,"RPL35A"]
["18.703","18.5615","19.4561","18.808","20.1444","20.3936",{"$nulls":3},"MyD88-dependent toll-like receptor signaling pathway;negative regulation of ERK1 and ERK2 cascade;negative regulation of I-kappaB kinase/NF-kappaB signaling;regulation of inflammatory response",null,"cytosol;nucleoplasm",{"$nulls":3},2,2,2,"10.1","10.1","10.1","27.826",0,"24.258",78196000,6,"0.706832",1,"-0.875191","-1.54854","tr|E7EW15|E7EW15_HUMAN;tr|E7EMV7|E7EMV7_HUMAN;tr|A0A0A0MRZ4|A0A0A0MRZ4_HUMAN;sp|Q15025|TNIP1_HUMAN","tr|E7EW15|E7EW15_HUMAN;tr|E7EMV7|E7EMV7_HUMAN;tr|A0A0A0MRZ4|A0A0A0MRZ4_HUMAN;sp|Q15025|TNIP1_HUMAN",2542,"E7EW15","E7EW15_HUMAN",null,null,"TNIP1"]
["19.2245","18.8921","18.5025","20.0184","19.0394","20.2069",{"$nulls":3},"autophagosome assembly;cellular defense response;cilium assembly;craniofacial suture morphogenesis;GTP metabolic process;negative regulation of transcription factor import into nucleus;protein transport","GTP binding;GTPase activity","autophagosome;cell junction;centrosome;cytoplasm;cytosol;endosome membrane;extracellular exosome;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane",{"$nulls":3},4,4,4,"21.9","21.9","21.9","26.659",0,"8.9854",110500000,13,"0.989909",1,"-0.881856","-2.11121","sp|Q9ULC3|RAB23_HUMAN","sp|Q9ULC3|RAB23_HUMAN",5113,"Q9ULC3","RAB23_HUMAN","Ras-related protein Rab-23",null,"RAB23"]
["18.4707","16.5001","18.5613","19.5748","17.1601","19.475",{"$nulls":3},"cholesterol biosynthetic process;regulation of cholesterol biosynthetic process;regulation of protein stability;steroid biosynthetic process","lanosterol synthase activity","endoplasmic reticulum membrane;lipid droplet;membrane","Metabolic pathways;Steroid biosynthesis",null,null,9,9,9,"16.3","16.3","16.3","83.308",0,"26.466",175700000,22,"0.358802",1,"-0.8926","-0.861137","sp|P48449|ERG7_HUMAN;tr|A0A0G2JQD0|A0A0G2JQD0_HUMAN;tr|C9J315|C9J315_HUMAN;tr|A0A0G2JS81|A0A0G2JS81_HUMAN","sp|P48449|ERG7_HUMAN;tr|A0A0G2JQD0|A0A0G2JQD0_HUMAN",1628,"P48449","ERG7_HUMAN","Lanosterol synthase",null,"LSS"]
["20.4089","19.9204","18.9712","21.2836","20.1093","20.656",{"$nulls":3},"amelogenesis;brown fat cell differentiation;cell adhesion mediated by integrin;cell-cell adhesion;cell-matrix adhesion;cell-substrate adhesion;cell-substrate junction assembly;cellular response to extracellular stimulus;cellular response to organic cyclic compound;digestive tract development;ectodermal cell differentiation;extracellular matrix organization;filopodium assembly;hemidesmosome assembly;integrin-mediated signaling pathway;leukocyte migration;nail development;negative regulation of extrinsic apoptotic signaling pathway;positive regulation of apoptotic process;positive regulation of cell migration;positive regulation of cell-cell adhesion;positive regulation of cell-substrate adhesion;positive regulation of GTPase activity;positive regulation of phosphorylation;positive regulation of transcription from RNA polymerase II promoter;renal system development;skin development","cadherin binding;insulin-like growth factor I binding;integrin binding;laminin binding;metal ion binding;neuregulin binding","basal plasma membrane;basement membrane;cell surface;cell-cell adherens junction;external side of plasma membrane;filopodium;focal adhesion;hemidesmosome;integrin alpha6-beta4 complex;plasma membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Cell adhesion molecules (CAMs);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Hematopoietic cell lineage;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);Pathways in cancer;PI3K-Akt signaling pathway;Regulation of actin cytoskeleton;Small cell lung cancer;Toxoplasmosis",null,null,27,27,27,"31.3","31.3","31.3","126.6",0,"93.585",1006700000,93,"0.780007",1,"-0.916122","-1.69173","sp|P23229|ITA6_HUMAN;tr|H7BZ97|H7BZ97_HUMAN;tr|C9JXX7|C9JXX7_HUMAN","sp|P23229|ITA6_HUMAN",1256,"P23229","ITA6_HUMAN","Integrin alpha-6",null,"ITGA6"]
["14.0301","14.1154","15.7734","15.712","15.2995","15.6588",{"$nulls":3},"Golgi to endosome transport;protein transport",null,"cytosol;extracellular exosome",{"$nulls":3},7,7,7,"6.4","6.4","6.4","190.36",0,"13.101",42578000,8,"0.720813",1,"-0.91715","-1.57583","sp|Q7Z3U7|MON2_HUMAN;tr|F8VZV1|F8VZV1_HUMAN;tr|F8VZV6|F8VZV6_HUMAN;tr|F8VQS2|F8VQS2_HUMAN","sp|Q7Z3U7|MON2_HUMAN;tr|F8VZV1|F8VZV1_HUMAN",3158,"Q7Z3U7","MON2_HUMAN","Protein MON2 homolog",null,"MON2"]
["20.4985","18.1445","20.3767","21.7696","19.4298","20.5853",{"$nulls":3},"brain development;cellular response to heat;cellular response to mechanical stimulus;extrinsic apoptotic signaling pathway in absence of ligand;extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of apoptotic process;negative regulation of striated muscle cell apoptotic process;negative regulation of transcription from RNA polymerase II promoter in response to stress;positive regulation of protein export from nucleus;positive regulation of transcription factor import into nucleus;protein folding;protein stabilization;regulation of cellular response to heat;spinal cord development","adenyl-nucleotide exchange factor activity;cadherin binding;chaperone binding;protein complex binding","cytoplasm;cytosol;neuron projection;nucleus;plasma membrane;Z disc",{"$nulls":3},16,16,16,49,49,49,"61.594",0,"63.942",441750000,42,"0.379254",1,"-0.921635","-0.903006","sp|O95817|BAG3_HUMAN;tr|C9JFK9|C9JFK9_HUMAN","sp|O95817|BAG3_HUMAN;tr|C9JFK9|C9JFK9_HUMAN",796,"O95817","BAG3_HUMAN","BAG family molecular chaperone regulator 3","AG-3","BAG3"]
[1,"14.3536","14.9177","17.3119",1,"14.7919",{"$nulls":3},"adiponectin-activated signaling pathway;cardiolipin biosynthetic process;long-chain fatty acid transport;medium-chain fatty acid transport;negative regulation of phospholipid biosynthetic process;phosphatidic acid biosynthetic process;phosphatidylcholine biosynthetic process;phosphatidylethanolamine biosynthetic process;phosphatidylglycerol biosynthetic process;phosphatidylinositol biosynthetic process;phosphatidylserine biosynthetic process;positive regulation of heat generation;positive regulation of protein serine/threonine kinase activity;regulation of lipid metabolic process;response to cold;response to insulin","fatty acid transmembrane transporter activity;long-chain fatty acid-CoA ligase activity;nucleotide binding;protein homodimerization activity;very long-chain fatty acid-CoA ligase activity","endoplasmic reticulum;integral component of membrane;membrane;plasma membrane","Insulin resistance;PPAR signaling pathway",null,null,3,3,3,"7.6","7.6","7.6","71.107","0.00041806","4.3671",20040000,4,"0.0474771",1,"-0.944173","-0.138628","sp|Q6PCB7|S27A1_HUMAN;tr|M0QZC9|M0QZC9_HUMAN;tr|B7Z225|B7Z225_HUMAN","sp|Q6PCB7|S27A1_HUMAN",3024,"Q6PCB7","S27A1_HUMAN","Long-chain fatty acid transport protein 1","ATP-1;atty acid transport protein 1","SLC27A1"]
["16.4269","15.9159","17.3708","18.8192","17.1169","16.6495",{"$nulls":3},"regulation of transcription, DNA-templated",{"$nulls":5},11,11,11,"11.8","11.8","11.8","154.31",0,"23.318",185580000,19,"0.538104",1,"-0.957297","-1.21944","sp|A3KN83|SBNO1_HUMAN;tr|K7ES28|K7ES28_HUMAN;sp|Q9Y2G9|SBNO2_HUMAN","sp|A3KN83|SBNO1_HUMAN",176,"A3KN83","SBNO1_HUMAN","Protein strawberry notch homolog 1",null,"SBNO1"]
["14.8345","15.4619","18.3986","17.4857","17.0607","17.0262",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;DNA repair;metaphase plate congression;microtubule-based movement;mitotic cell cycle;mitotic metaphase plate congression;retrograde vesicle-mediated transport, Golgi to ER;sister chromatid cohesion","ATP binding;ATPase activity;DNA binding;microtubule binding;microtubule motor activity","chromatin;cytosol;kinesin complex;kinetochore;microtubule;mitotic spindle;nuclear speck;nucleus","Progesterone-mediated oocyte maturation",null,null,16,16,16,"31.9","31.9","31.9","73.261",0,"40.159",323040000,39,"0.360867",1,"-0.959173","-0.865382","sp|Q14807|KIF22_HUMAN;tr|H3BRB3|H3BRB3_HUMAN;tr|H3BTH5|H3BTH5_HUMAN;tr|I3L306|I3L306_HUMAN","sp|Q14807|KIF22_HUMAN;tr|H3BRB3|H3BRB3_HUMAN;tr|H3BTH5|H3BTH5_HUMAN",2510,"Q14807","KIF22_HUMAN","Kinesin-like protein KIF22",null,"KIF22"]
["18.4731","16.9165","18.4472","19.1794","18.5359","19.0384",{"$nulls":4},"ATP binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;nucleic acid binding;zinc ion binding","nucleoplasm;nucleus",{"$nulls":3},21,21,21,"29.4","29.4","29.4","113.86",0,"63.757",487180000,59,"0.817984",1,"-0.972303","-1.76649","tr|A0A0C4DGA6|A0A0C4DGA6_HUMAN;sp|Q14527|HLTF_HUMAN;tr|H7C5K0|H7C5K0_HUMAN","tr|A0A0C4DGA6|A0A0C4DGA6_HUMAN;sp|Q14527|HLTF_HUMAN",2478,"A0A0C4DGA6","A0A0C4DGA6_HUMAN",null,null,"HLTF"]
["18.1631","17.0244","17.606","19.4975","16.7803","19.4343",{"$nulls":3},"angiogenesis;embryo development;fucose metabolic process;heart development;nervous system development;Notch signaling pathway;O-glycan processing;protein O-linked fucosylation;protein O-linked glycosylation;regulation of Notch signaling pathway;regulation of transcription, DNA-templated;somitogenesis","fucosyltransferase activity;peptide-O-fucosyltransferase activity","endoplasmic reticulum;membrane","Other types of O-glycan biosynthesis",null,null,4,4,4,"17.3","17.3","17.3","43.955",0,"19.372",83223000,7,"0.437225",1,"-0.972895","-1.01999","sp|Q9H488|OFUT1_HUMAN","sp|Q9H488|OFUT1_HUMAN",4459,"Q9H488","OFUT1_HUMAN","GDP-fucose protein O-fucosyltransferase 1",null,"POFUT1"]
["18.5058","13.4298","17.501","18.2356","17.0914","17.132",{"$nulls":3},"endocytosis",{"$nulls":5},2,2,2,6,6,6,"64.071","0.00061488","3.9711",51794000,6,"0.250052",1,"-1.00746","-0.631042","tr|B7ZL14|B7ZL14_HUMAN;tr|H0Y7W6|H0Y7W6_HUMAN;sp|Q96RU3|FNBP1_HUMAN","tr|B7ZL14|B7ZL14_HUMAN;tr|H0Y7W6|H0Y7W6_HUMAN;sp|Q96RU3|FNBP1_HUMAN",4027,"B7ZL14","B7ZL14_HUMAN"]
["17.6223","15.6587","16.0311","20.2357","15.5607","16.5494",{"$nulls":3},"cell adhesion;cell motility;cytoskeleton organization;hemidesmosome assembly;integrin-mediated signaling pathway;intermediate filament cytoskeleton organization;maintenance of cell polarity;microtubule cytoskeleton organization;response to wounding;retrograde axonal transport","actin binding;calcium ion binding;integrin binding;microtubule plus-end binding;protein C-terminus binding;protein homodimerization activity","actin cytoskeleton;axon;axon cytoplasm;basal plasma membrane;basement membrane;cell cortex;cell leading edge;cytoplasm;cytoplasmic vesicle;cytosol;endoplasmic reticulum membrane;extracellular exosome;focal adhesion;H zone;hemidesmosome;integral component of membrane;intermediate filament;intermediate filament cytoskeleton;microtubule cytoskeleton;microtubule plus-end;nuclear envelope;nucleus;Z disc",{"$nulls":3},30,29,29,8,"7.7","7.7","615.65",0,"84.131",757070000,45,"0.260898",1,"-1.01127","-0.654685","tr|E7ERU0|E7ERU0_HUMAN;tr|E9PHM6|E9PHM6_HUMAN;tr|F6QMI7|F6QMI7_HUMAN;tr|E9PEB9|E9PEB9_HUMAN;tr|F8W9J4|F8W9J4_HUMAN;sp|Q03001|DYST_HUMAN;tr|E7ETB9|E7ETB9_HUMAN;tr|Q6P0N6|Q6P0N6_HUMAN;tr|Q5T0V7|Q5T0V7_HUMAN;tr|H0YC65|H0YC65_HUMAN;tr|H0YC82|H0YC82_HUMAN","tr|E7ERU0|E7ERU0_HUMAN;tr|E9PHM6|E9PHM6_HUMAN;tr|F6QMI7|F6QMI7_HUMAN;tr|E9PEB9|E9PEB9_HUMAN;tr|F8W9J4|F8W9J4_HUMAN;sp|Q03001|DYST_HUMAN",2169,"E7ERU0","DYST_HUMAN","Dystonin",null,"DST"]
["15.4696",1,"14.2617","18.4796","14.2973",1,{"$nulls":3},"cell cycle;protein transport;regulation of ER to Golgi vesicle-mediated transport;regulation of signal transduction involved in mitotic G2 DNA damage checkpoint;retrograde vesicle-mediated transport, Golgi to ER",null,"cytosol;Dsl1/NZR complex;endoplasmic reticulum;endoplasmic reticulum membrane",{"$nulls":3},3,3,3,"6.4","6.4","6.4","90.631",0,"8.9967",40419000,6,"0.0496463",1,"-1.01521","-0.144658","sp|Q6NUQ1|RINT1_HUMAN;tr|C9J5S3|C9J5S3_HUMAN","sp|Q6NUQ1|RINT1_HUMAN",2980,"Q6NUQ1","RINT1_HUMAN","RAD50-interacting protein 1",null,"RINT1"]
["18.5035","14.7399","17.7284","19.1302","16.6607","18.2529",{"$nulls":3},"cellular protein complex assembly;chaperone cofactor-dependent protein refolding;chaperone mediated protein folding requiring cofactor","Hsp70 protein binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;nuclear membrane",{"$nulls":3},4,4,4,"12.7","12.7","12.7","42.515",0,"8.5809",70821000,8,"0.307867",1,"-1.02401","-0.755141","sp|Q8TBM8|DJB14_HUMAN","sp|Q8TBM8|DJB14_HUMAN",3545,"Q8TBM8","DJB14_HUMAN","DnaJ homolog subfamily B member 14 {ECO:0000312|HGNC:HGNC:25881}",null,"DNAJB14"]
["17.1336","17.4891","17.9811","18.2271","18.3193","19.2061",{"$nulls":3},"endocytosis;membrane organization;protein transport",null,"clathrin vesicle coat;clathrin-coated pit;cytosol;plasma membrane",{"$nulls":3},2,2,2,"11.6","11.6","11.6","29.737","0.002849","2.8426",32489000,3,"1.24076",1,"-1.04958","-2.64229","sp|Q8NC96|NECP1_HUMAN;tr|F5GYH1|F5GYH1_HUMAN;tr|F5H2U7|F5H2U7_HUMAN","sp|Q8NC96|NECP1_HUMAN;tr|F5GYH1|F5GYH1_HUMAN;tr|F5H2U7|F5H2U7_HUMAN",3470,"Q8NC96","NECP1_HUMAN","Adaptin ear-binding coat-associated protein 1",null,"NECAP1"]
["17.1371","15.017","18.157","18.761","15.9889","18.7327",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);post-translational protein modification;protein ubiquitination;rRNA processing","estrogen receptor binding;RNA binding","cell junction;centrosome;Cul4-RING E3 ubiquitin ligase complex;cytosol;nucleolus;nucleoplasm;nucleus;small-subunit processome",{"$nulls":3},8,8,8,"23.6","23.6","23.6","51.402",0,"23.626",285360000,18,"0.334409",1,"-1.05718","-0.81071","sp|Q9NV06|DCA13_HUMAN;tr|A0A087WT20|A0A087WT20_HUMAN;tr|A0A087X1F8|A0A087X1F8_HUMAN;tr|B3KME9|B3KME9_HUMAN;tr|E5RHM4|E5RHM4_HUMAN","sp|Q9NV06|DCA13_HUMAN;tr|A0A087WT20|A0A087WT20_HUMAN;tr|A0A087X1F8|A0A087X1F8_HUMAN",4747,"Q9NV06","DCA13_HUMAN","DDB1- and CUL4-associated factor 13",null,"DCAF13"]
["18.0639","17.6608","20.8708","20.9268","19.8314","19.0892",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"22.5","22.5","22.5","18.244",0,"9.4312",58018000,7,"0.402011",1,"-1.08394","-0.9492","tr|H0YDX2|H0YDX2_HUMAN;sp|Q9NPA0|EMC7_HUMAN;tr|H0YDT8|H0YDT8_HUMAN","tr|H0YDX2|H0YDX2_HUMAN;sp|Q9NPA0|EMC7_HUMAN;tr|H0YDT8|H0YDT8_HUMAN",4629,"H0YDX2","H0YDX2_HUMAN",null,null,"EMC7"]
["17.4557","15.7029","17.0237","18.1835","16.8754","18.4165",{"$nulls":3},"apoptotic process;cell differentiation;cell proliferation;cellular response to interferon-beta;defense response to virus;mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;regulation of type I interferon production;RNA secondary structure unwinding","ATP binding;ATP-dependent RNA helicase activity;DNA binding;metal ion binding;RNA binding","catalytic step 2 spliceosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleolus;nucleus",{"$nulls":3},19,19,17,"41.6","41.6","38.7","69.837",0,"59.056",607720000,72,"0.702542",1,"-1.09772","-1.54017","sp|Q9UJV9|DDX41_HUMAN;tr|J3KNN5|J3KNN5_HUMAN;tr|D6RGI7|D6RGI7_HUMAN;tr|H0Y8L8|H0Y8L8_HUMAN;tr|D6RD33|D6RD33_HUMAN","sp|Q9UJV9|DDX41_HUMAN;tr|J3KNN5|J3KNN5_HUMAN",5065,"Q9UJV9","DDX41_HUMAN","Probable ATP-dependent RNA helicase DDX41",null,"DDX41"]
["13.3907","12.5477",1,"13.7823","15.4679",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},9,9,9,"13.6","13.6","13.6","125.38",0,"19.274",93461000,26,"0.0632213",1,"-1.10391","-0.181873","tr|A0A087WVA8|A0A087WVA8_HUMAN;sp|Q8IWB9|TEX2_HUMAN;tr|J3KRZ8|J3KRZ8_HUMAN","tr|A0A087WVA8|A0A087WVA8_HUMAN;sp|Q8IWB9|TEX2_HUMAN;tr|J3KRZ8|J3KRZ8_HUMAN",3301,"A0A087WVA8","A0A087WVA8_HUMAN",null,null,"TEX2"]
["18.8131","17.5326","18.8658","20.3529","19.8801","18.3374",{"$nulls":3},"peptide metabolic process;protein processing involved in protein targeting to mitochondrion","metal ion binding;metalloendopeptidase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},8,8,8,"16.1","16.1","16.1","80.64",0,"18.822",210300000,14,"0.679773",1,"-1.11966","-1.49578","sp|Q99797|MIPEP_HUMAN","sp|Q99797|MIPEP_HUMAN",4108,"Q99797","MIPEP_HUMAN","Mitochondrial intermediate peptidase","IP","MIPEP"]
["17.3417","16.9556","18.2264","19.7941","17.2779","18.8668",{"$nulls":9},10,10,10,"46.5","46.5","46.5","25.456",0,"65.834",429170000,53,"0.619901",1,"-1.13837","-1.37917","sp|Q9NSI2|F207A_HUMAN;tr|C9JJU7|C9JJU7_HUMAN","sp|Q9NSI2|F207A_HUMAN;tr|C9JJU7|C9JJU7_HUMAN",4714,"Q9NSI2","F207A_HUMAN","Protein FAM207A",null,"FAM207A"]
["16.3659",1,"18.0084","19.8002",1,"18.0524",{"$nulls":3},"behavioral fear response;cell adhesion;endothelial cell migration;locomotory exploration behavior;negative regulation of extracellular matrix disassembly;positive regulation of cell proliferation;proteolysis;psychomotor behavior;regulation of cell-cell adhesion mediated by integrin;regulation of insulin secretion;response to hypoxia;T cell activation;T cell costimulation","dipeptidyl-peptidase activity;identical protein binding;protease binding;protein homodimerization activity;receptor binding;serine-type endopeptidase activity;serine-type peptidase activity;virus receptor activity","apical plasma membrane;cell surface;endocytic vesicle;extracellular exosome;extracellular region;focal adhesion;integral component of membrane;intercellular canaliculus;invadopodium membrane;lamellipodium;lamellipodium membrane;lysosomal membrane;membrane;membrane raft;plasma membrane","Protein digestion and absorption",null,null,2,2,2,"3.3","3.3","3.3","88.278","0.0052045","2.4944",99061000,5,"0.0492225",1,"-1.15944","-0.143482","sp|P27487|DPP4_HUMAN","sp|P27487|DPP4_HUMAN",1322,"P27487","DPP4_HUMAN","Dipeptidyl peptidase 4",null,"DPP4"]
["17.6686","18.4147","19.3128","19.8336","19.51","19.6231",{"$nulls":3},"7-methylguanosine mRNA capping;RNA processing;transcription from RNA polymerase II promoter;viral process","GTP binding;mRNA guanylyltransferase activity;polynucleotide 5'-phosphatase activity;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity;RNA guanylyltransferase activity;triphosphatase activity","nucleoplasm;nucleus","mRNA surveillance pathway",null,null,7,7,7,"16.9","16.9","16.9","68.556",0,"23.466",201030000,15,"1.15478",1,"-1.19017","-2.45563","sp|O60942|MCE1_HUMAN","sp|O60942|MCE1_HUMAN",539,"O60942","MCE1_HUMAN","mRNA-capping enzyme",null,"RNGTT"]
["18.9665","19.1176","19.4805","21.3592","19.3896","20.5148",{"$nulls":3},"cholesterol biosynthetic process;ergosterol biosynthetic process;farnesyl diphosphate metabolic process;isoprenoid biosynthetic process;regulation of cholesterol biosynthetic process;regulation of lipid metabolic process;steroid biosynthetic process","farnesyl-diphosphate farnesyltransferase activity;oxidoreductase activity;squalene synthase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Metabolic pathways;Steroid biosynthesis",null,null,11,11,11,"38.8","38.8","38.8","48.115",0,"73.665",268760000,29,"0.97853",1,"-1.23303","-2.088","sp|P37268|FDFT_HUMAN;tr|E9PNM1|E9PNM1_HUMAN;tr|E9PS69|E9PS69_HUMAN;tr|E9PJG4|E9PJG4_HUMAN","sp|P37268|FDFT_HUMAN;tr|E9PNM1|E9PNM1_HUMAN",1496,"P37268","FDFT_HUMAN","Squalene synthase","QS;S","FDFT1"]
["19.3502","12.9643","19.1415","19.4082","16.48","19.27",{"$nulls":3},"cellular protein metabolic process;intracellular protein transport;vesicle-mediated transport","ADP-ribosylation factor binding","clathrin adaptor complex;clathrin-coated vesicle;early endosome membrane;endosome membrane;Golgi apparatus;trans-Golgi network","Lysosome",null,null,5,4,4,"15.8","14.7","14.7","67.15",0,"36.548",107910000,15,"0.207417",1,"-1.23407","-0.536163","sp|Q9UJY4|GGA2_HUMAN;tr|H3BMM6|H3BMM6_HUMAN;tr|H3BMN6|H3BMN6_HUMAN;tr|I3L2C4|I3L2C4_HUMAN","sp|Q9UJY4|GGA2_HUMAN",5072,"Q9UJY4","GGA2_HUMAN","ADP-ribosylation factor-binding protein GGA2",null,"GGA2"]
["18.3726","16.1175","17.607","20.5343","16.9291","18.4368",{"$nulls":3},"apoptotic process involved in morphogenesis;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand",null,"extracellular exosome;membrane raft","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Chagas disease (American trypanosomiasis);Dopaminergic synapse;Hepatitis C;Hippo signaling pathway;Human papillomavirus infection;Long-term depression;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway;TGF-beta signaling pathway;Tight junction",null,null,12,7,7,"31.6","17.3","17.3","66.213",0,"35.191",96788000,19,"0.439489",1,"-1.26771","-1.02451","sp|P30154|2AAB_HUMAN;tr|H0YDG7|H0YDG7_HUMAN","sp|P30154|2AAB_HUMAN;tr|H0YDG7|H0YDG7_HUMAN",1378,"P30154","2AAB_HUMAN","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform",null,"PPP2R1B"]
["22.1885","20.5387","17.3745","22.2259","20.837","20.8773",{"$nulls":3},"covalent chromatin modification;DNA repair;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;muscle cell differentiation;negative regulation of chromatin silencing;nucleosome assembly;osteoblast differentiation;transcription, DNA-templated","chromatin binding;histone binding","nuclear chromatin;nucleoplasm;nucleus;protein complex",{"$nulls":3},8,8,7,48,48,"44.1","22.968",0,"123.95",581060000,44,"0.359237",1,"-1.27952","-0.862032","sp|Q9Y294|ASF1A_HUMAN","sp|Q9Y294|ASF1A_HUMAN",5214,"Q9Y294","ASF1A_HUMAN","Histone chaperone ASF1A",null,"ASF1A"]
["20.8614","19.5779",1,"23.2379","21.0956",1,{"$nulls":9},2,2,2,"51.6","51.6","51.6","7.3314",0,"13.298",79229000,5,"0.0464688",1,"-1.29806","-0.135817","tr|E9PQD0|E9PQD0_HUMAN;tr|E9PS30|E9PS30_HUMAN;tr|E9PLI6|E9PLI6_HUMAN;tr|E9PS76|E9PS76_HUMAN;sp|Q8N9N8|EIF1A_HUMAN","tr|E9PQD0|E9PQD0_HUMAN;tr|E9PS30|E9PS30_HUMAN;tr|E9PLI6|E9PLI6_HUMAN;tr|E9PS76|E9PS76_HUMAN;sp|Q8N9N8|EIF1A_HUMAN",3441,"E9PQD0","E9PQD0_HUMAN",null,null,"EIF1AD"]
["17.2387","16.5087","16.5163","19.3378","16.9401","18.0999",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;basement membrane organization;cell migration involved in gastrulation;cell-cell adhesion involved in gastrulation;G-protein coupled receptor signaling pathway;in utero embryonic development;vasculature development;visual learning","G-protein alpha-subunit binding;GTPase activator activity;guanyl-nucleotide exchange factor activity","cytoplasm;plasma membrane",{"$nulls":3},4,4,4,"13.6","13.6","13.6","59.709",0,"19.102",61548000,9,"0.870146",1,"-1.37138","-1.86987","sp|Q9NPQ8|RIC8A_HUMAN;tr|H0YEN0|H0YEN0_HUMAN;tr|H0YE35|H0YE35_HUMAN;tr|E9PI04|E9PI04_HUMAN;sp|Q9NVN3|RIC8B_HUMAN;tr|B7WPL0|B7WPL0_HUMAN","sp|Q9NPQ8|RIC8A_HUMAN;tr|H0YEN0|H0YEN0_HUMAN",4646,"Q9NPQ8","RIC8A_HUMAN","Synembryn-A",null,"RIC8A"]
["19.1949","13.7736","17.9746","20.057","16.9186","18.1511",{"$nulls":3},"glutamyl-tRNA aminoacylation","ATP binding;glutamate-tRNA ligase activity;tRNA binding;zinc ion binding","cytoplasm",{"$nulls":3},8,8,8,"19.6","19.6","19.6","56.825",0,"19.976",127390000,19,"0.301778",1,"-1.39451","-0.74228","tr|H3BTB7|H3BTB7_HUMAN;sp|Q5JPH6|SYEM_HUMAN","tr|H3BTB7|H3BTB7_HUMAN;sp|Q5JPH6|SYEM_HUMAN",2820,"H3BTB7","H3BTB7_HUMAN",null,null,"EARS2"]
["15.2002","17.4379","17.5935","18.5071","17.7628","18.3122",{"$nulls":3},"protein dephosphorylation;protein phosphorylation;signal transduction","protein phosphatase regulator activity","protein phosphatase 4 complex",{"$nulls":3},7,7,7,"8.9","8.9","8.9",107,0,"17.26",102690000,14,"0.836076",1,"-1.45013","-1.80225","sp|Q8TF05|PP4R1_HUMAN;tr|J3QL26|J3QL26_HUMAN;tr|J3KSB0|J3KSB0_HUMAN;tr|J3QLA6|J3QLA6_HUMAN;tr|J3QQV0|J3QQV0_HUMAN;tr|J3KRU1|J3KRU1_HUMAN","sp|Q8TF05|PP4R1_HUMAN;tr|J3QL26|J3QL26_HUMAN;tr|J3KSB0|J3KSB0_HUMAN;tr|J3QLA6|J3QLA6_HUMAN",3585,"Q8TF05","PP4R1_HUMAN","Serine/threonine-protein phosphatase 4 regulatory subunit 1",null,"PPP4R1"]
["16.6972","16.2159","18.2627","19.8079","17.6268","18.3535",{"$nulls":3},"7-methylguanosine mRNA capping;global genome nucleotide-excision repair;G-protein coupled receptor internalization;nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;protein phosphorylation;regulation of transcription from RNA polymerase II promoter;response to UV;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair","DNA binding transcription factor activity;nucleic acid binding;protein N-terminus binding;translation factor activity, RNA binding;zinc ion binding","core TFIIH complex portion of holo TFIIH complex;holo TFIIH complex;nuclear speck;nucleoplasm;nucleus;transcription factor TFIID complex","Basal transcription factors;Nucleotide excision repair;Viral carcinogenesis",null,null,6,6,6,23,23,23,"44.419",0,"8.3906",258380000,16,"0.797726",1,"-1.53744","-1.72656","sp|Q13888|TF2H2_HUMAN;sp|Q6P1K8|T2H2L_HUMAN;tr|D6RID8|D6RID8_HUMAN;tr|R4GMS9|R4GMS9_HUMAN;tr|D6RJD3|D6RJD3_HUMAN;tr|D6RAW1|D6RAW1_HUMAN;tr|D6RIT7|D6RIT7_HUMAN;tr|D6RGC9|D6RGC9_HUMAN","sp|Q13888|TF2H2_HUMAN;sp|Q6P1K8|T2H2L_HUMAN;tr|D6RID8|D6RID8_HUMAN",2419,"Q13888","TF2H2_HUMAN","General transcription factor IIH subunit 2",null,"GTF2H2"]
["17.1243","16.2496","15.7596","18.6834","16.9326","18.2584",{"$nulls":3},"cell division;chromosome segregation;mitotic cell cycle;sister chromatid cohesion",null,"chromosome, centromeric region;condensed chromosome kinetochore;cytosol;membrane;Ndc80 complex;nucleus",{"$nulls":3},4,4,4,"10.6","10.6","10.6","54.303","0.00021716","5.2748",45208000,3,"1.12383",1,"-1.58028","-2.3897","sp|Q9BZD4|NUF2_HUMAN;tr|E9PQC4|E9PQC4_HUMAN;tr|B1AQT4|B1AQT4_HUMAN;tr|E9PP32|E9PP32_HUMAN","sp|Q9BZD4|NUF2_HUMAN;tr|E9PQC4|E9PQC4_HUMAN",4326,"Q9BZD4","NUF2_HUMAN","Kinetochore protein Nuf2","Nuf2;Nuf2R;sNuf2","NUF2"]
["15.6708","15.2268","15.6432","16.6134","15.6517","19.1343",{"$nulls":3},"embryonic body morphogenesis;negative regulation of gene expression;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;stem cell differentiation;transcription, DNA-templated","core promoter binding;DNA binding transcription factor activity;metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding;sequence-specific DNA binding;transcription corepressor activity;transcription regulatory region DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nucleoplasm;nucleus",{"$nulls":3},14,14,14,"31.7","31.7","31.7","96.914",0,"36.774",218420000,33,"0.704971",1,"-1.61951","-1.54491","sp|Q9Y2X9|ZN281_HUMAN","sp|Q9Y2X9|ZN281_HUMAN",5253,"Q9Y2X9","ZN281_HUMAN","Zinc finger protein 281",null,"ZNF281"]
["15.8045","13.8758",1,"17.742","16.879",1,{"$nulls":3},"cellular response to interleukin-4;cytoplasmic sequestering of transcription factor;in utero embryonic development;negative regulation of DNA binding transcription factor activity;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;post-translational protein modification;proteasomal ubiquitin-independent protein catabolic process;protein deubiquitination;protein ubiquitination;regulation of epidermal cell differentiation;transcription, DNA-templated","disordered domain specific binding;protein homodimerization activity;transcription factor binding","actin filament;Cul3-RING ubiquitin ligase complex;cytoplasm;cytosol;endoplasmic reticulum;microtubule organizing center;midbody;nucleoplasm;protein complex","Fluid shear stress and atherosclerosis;Hepatocellular carcinoma;Pathways in cancer;Ubiquitin mediated proteolysis",null,null,3,3,3,"5.1","5.1","5.1","69.666","0.00041348","4.1605",38935000,1,"0.0812967",1,"-1.64688","-0.230125","sp|Q14145|KEAP1_HUMAN;tr|K7EPZ3|K7EPZ3_HUMAN;tr|K7EQX2|K7EQX2_HUMAN;tr|K7EJ49|K7EJ49_HUMAN;tr|K7EJD8|K7EJD8_HUMAN;tr|K7ESE0|K7ESE0_HUMAN","sp|Q14145|KEAP1_HUMAN",2439,"Q14145","KEAP1_HUMAN","Kelch-like ECH-associated protein 1",null,"KEAP1"]
["20.9229","19.593","20.2782","22.7148","21.1808","22.1264",{"$nulls":3},"amelogenesis;autophagy;cell adhesion;cell motility;cell-matrix adhesion;digestive tract development;extracellular matrix organization;hemidesmosome assembly;integrin-mediated signaling pathway;mesodermal cell differentiation;nail development;renal system development;response to wounding;skin development","G-protein coupled receptor binding;receptor activity","cell junction;cell leading edge;cell surface;extracellular exosome;hemidesmosome;integrin complex;nucleus;plasma membrane;receptor complex","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);PI3K-Akt signaling pathway;Regulation of actin cytoskeleton",null,null,44,44,35,"32.5","32.5","25.9","202.16",0,"323.31",2667400000,187,"1.3805",1,"-1.74261","-2.95795","sp|P16144|ITB4_HUMAN;tr|J3QQL2|J3QQL2_HUMAN;tr|J3QRK0|J3QRK0_HUMAN;tr|J3KSH9|J3KSH9_HUMAN","sp|P16144|ITB4_HUMAN",1130,"P16144","ITB4_HUMAN","Integrin beta-4",null,"ITGB4"]
["17.1051","13.8801","17.1894","19.6199","15.8461","18.5048",{"$nulls":3},"RNA secondary structure unwinding","ATP binding;ATP-dependent RNA helicase activity;RNA binding;RNA helicase activity","cytoplasm;nucleolus",{"$nulls":3},28,28,28,"38.4","38.4","38.4","100.89",0,"97.81",839010000,65,"0.547061",1,"-1.93208","-1.23698","sp|Q13206|DDX10_HUMAN;tr|E9PIF2|E9PIF2_HUMAN","sp|Q13206|DDX10_HUMAN;tr|E9PIF2|E9PIF2_HUMAN",2325,"Q13206","DDX10_HUMAN","Probable ATP-dependent RNA helicase DDX10",null,"DDX10"]
["14.121","12.3097",1,"15.4177",1,"17.9476",{"$nulls":3},"cholesterol metabolic process;cholesterol transport;Golgi to plasma membrane transport;phosphatidylserine acyl-chain remodeling;phospholipid transport","cholesterol binding;oxysterol binding;phosphatidylinositol-4-phosphate binding;phosphatidylserine binding;phospholipid transporter activity","cytosol;endoplasmic reticulum membrane;integral component of membrane;intracellular membrane-bounded organelle;membrane","Cholesterol metabolism",null,null,14,10,10,"17.9","14.7","14.7","98.615",0,"29.335",165260000,29,"0.12668",1,"-2.3115","-0.34568","sp|Q9H0X9|OSBL5_HUMAN;tr|H0YCD7|H0YCD7_HUMAN;tr|E9PNH0|E9PNH0_HUMAN;tr|E9PLN3|E9PLN3_HUMAN;tr|E9PQB4|E9PQB4_HUMAN;tr|E9PIJ6|E9PIJ6_HUMAN;tr|E9PRA9|E9PRA9_HUMAN;tr|E9PJE6|E9PJE6_HUMAN;tr|E9PPQ2|E9PPQ2_HUMAN","sp|Q9H0X9|OSBL5_HUMAN;tr|H0YCD7|H0YCD7_HUMAN",4405,"Q9H0X9","OSBL5_HUMAN","Oxysterol-binding protein-related protein 5","RP-5;SBP-related protein 5","OSBPL5"]
["12.3461","13.0501","17.3462","18.7296","15.3979","17.4905",{"$nulls":5},"mitochondrion",{"$nulls":3},4,4,4,"0.4","0.4","0.4","780.6","0.0011888","3.4321",779040000,12,"0.737044",1,"-2.95854","-1.60755","sp|Q5CZC0|FSIP2_HUMAN;tr|J3QTJ6|J3QTJ6_HUMAN;tr|A0A087WUX3|A0A087WUX3_HUMAN","sp|Q5CZC0|FSIP2_HUMAN;tr|J3QTJ6|J3QTJ6_HUMAN",2806,"Q5CZC0","FSIP2_HUMAN","Fibrous sheath-interacting protein 2",null,"FSIP2"]
["22.1748",1,1,"19.4627","13.9833",1,{"$nulls":3},"L-glutamate transport;protein transport",null,"endosome membrane;integral component of membrane",{"$nulls":3},2,2,2,"16.3","16.3","16.3","19.258",0,"11.343",88972000,11,"0.142064",1,"-3.42377","-0.383294","sp|O60831|PRAF2_HUMAN;tr|A6NP52|A6NP52_HUMAN;tr|A6NM71|A6NM71_HUMAN","sp|O60831|PRAF2_HUMAN;tr|A6NP52|A6NP52_HUMAN;tr|A6NM71|A6NM71_HUMAN",528,"O60831","PRAF2_HUMAN","PRA1 family protein 2",null,"PRAF2"]
[1,"15.2074",1,"12.2223","14.6054",1,{"$nulls":3},"cortical actin cytoskeleton organization;cytoskeleton organization;regulation of cell morphogenesis","actin binding;cadherin binding;Rho GTPase binding","cytosol",{"$nulls":3},13,13,13,"13.5","13.5","13.5","123.32",0,"39.9",237890000,40,"0.217802",1,"-3.54014","-0.559579","sp|Q96PY5|FMNL2_HUMAN;tr|C9IZY8|C9IZY8_HUMAN;tr|F8W1F5|F8W1F5_HUMAN;sp|Q8IVF7|FMNL3_HUMAN;sp|O95466|FMNL1_HUMAN","sp|Q96PY5|FMNL2_HUMAN;tr|C9IZY8|C9IZY8_HUMAN",3999,"Q96PY5","FMNL2_HUMAN","Formin-like protein 2",null,"FMNL2"]
["15.8088","15.3588",1,"15.6717","12.4333","15.2508",{"$nulls":3},"apoptotic DNA fragmentation;conversion of ds siRNA to ss siRNA;conversion of ds siRNA to ss siRNA involved in RNA interference;miRNA loading onto RISC involved in gene silencing by miRNA;miRNA metabolic process;negative regulation of Schwann cell proliferation;negative regulation of transcription from RNA polymerase II promoter;nerve development;neuron projection morphogenesis;peripheral nervous system myelin formation;positive regulation of myelination;positive regulation of Schwann cell differentiation;pre-miRNA processing;production of miRNAs involved in gene silencing by miRNA;production of siRNA involved in RNA interference;RNA phosphodiester bond hydrolysis, endonucleolytic;siRNA loading onto RISC involved in RNA interference;targeting of mRNA for destruction involved in RNA interference","ATP binding;deoxyribonuclease I activity;DNA binding;double-stranded RNA binding;endoribonuclease activity;helicase activity;metal ion binding;pre-miRNA binding;protein domain specific binding;ribonuclease III activity;siRNA binding","ARC complex;axon;cytoplasm;cytosol;dendrite;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;growth cone;micro-ribonucleoprotein complex;nucleus;RISC-loading complex","MicroRNAs in cancer",null,null,3,3,3,2,2,2,"218.68",0,"7.8587",28654000,4,"0.305747",1,"-3.7294","-0.750668","sp|Q9UPY3|DICER_HUMAN","sp|Q9UPY3|DICER_HUMAN",5183,"Q9UPY3","DICER_HUMAN","Endoribonuclease Dicer",null,"DICER1"]
[1,"13.2986","13.0585","12.5446","13.6286","12.7374",{"$nulls":3},"negative regulation of G0 to G1 transition;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;protein dimerization activity","MLL1 complex;nucleoplasm",{"$nulls":3},5,5,5,"2.6","2.6","2.6","331.83",0,"42.692",92151000,13,"0.400099",1,"-3.85112","-0.945333","sp|Q8IWI9|MGAP_HUMAN;tr|H3BP52|H3BP52_HUMAN;tr|H3BTF4|H3BTF4_HUMAN;tr|H3BU53|H3BU53_HUMAN","sp|Q8IWI9|MGAP_HUMAN;tr|H3BP52|H3BP52_HUMAN;tr|H3BTF4|H3BTF4_HUMAN",3305,"Q8IWI9","MGAP_HUMAN","MAX gene-associated protein",null,"MGA"]
["18.9482","15.6344",1,"18.9652","14.487","13.9344",{"$nulls":3},"actin cytoskeleton organization;positive regulation of GTPase activity;regulation of ARF protein signal transduction","ARF guanyl-nucleotide exchange factor activity;lipid binding","cytoplasm;intracellular membrane-bounded organelle;membrane;nucleolus","Endocytosis",null,null,9,9,7,"12.9","12.9","11.2","108.31",0,"25.597",201050000,20,"0.275179",1,"-3.93469","-0.685548","sp|Q6DN90|IQEC1_HUMAN;tr|A0A087WWK8|A0A087WWK8_HUMAN;tr|A0A0C4DGT3|A0A0C4DGT3_HUMAN","sp|Q6DN90|IQEC1_HUMAN;tr|A0A087WWK8|A0A087WWK8_HUMAN;tr|A0A0C4DGT3|A0A0C4DGT3_HUMAN",2948,"Q6DN90","IQEC1_HUMAN","IQ motif and SEC7 domain-containing protein 1",null,"IQSEC1"]
["20.3826","17.5608",1,"16.8688","17.9257","16.1605",{"$nulls":3},"cell division;ciliary basal body-plasma membrane docking;cytoskeleton-dependent intracellular transport;G2/M transition of mitotic cell cycle;microtubule-based process;regulation of G2/M transition of mitotic cell cycle","GTP binding;GTPase activity;protein domain specific binding;structural constituent of cytoskeleton;structural molecule activity","cytoplasmic microtubule;cytoplasmic ribonucleoprotein granule;cytosol;extracellular exosome;membrane raft;microtubule;microtubule cytoskeleton;myelin sheath;nucleus;recycling endosome","Apoptosis;Gap junction;Pathogenic Escherichia coli infection;Phagosome;Tight junction",null,null,29,3,1,"66.5","6.2","3.1","50.135",0,"19.129",143480000,7,"0.263301",1,"-4.00388","-0.6599","sp|Q71U36|TBA1A_HUMAN;sp|Q13748|TBA3C_HUMAN;sp|Q6PEY2|TBA3E_HUMAN;tr|F8VQQ4|F8VQQ4_HUMAN","sp|Q71U36|TBA1A_HUMAN;sp|Q13748|TBA3C_HUMAN;sp|Q6PEY2|TBA3E_HUMAN",3108,"Q71U36","TBA1A_HUMAN","Tubulin alpha-1A chain",null,"TUBA1A"]
[1,1,"19.3123","17.2621","15.3795",1,{"$nulls":3},"regulation of exocytosis","GTP binding","synaptic vesicle",{"$nulls":3},2,2,2,10,10,10,"20.612","0.0078769","2.2905",20376000,2,"0.198195",1,"-4.10976","-0.515188","tr|F8W9E5|F8W9E5_HUMAN;tr|E7EQM7|E7EQM7_HUMAN;tr|C9JM82|C9JM82_HUMAN;tr|E7EPG2|E7EPG2_HUMAN;tr|B4DJ62|B4DJ62_HUMAN;tr|E7EX32|E7EX32_HUMAN;sp|Q99719|SEPT5_HUMAN;tr|G3XAH0|G3XAH0_HUMAN;tr|A0A087WWZ5|A0A087WWZ5_HUMAN","tr|F8W9E5|F8W9E5_HUMAN;tr|E7EQM7|E7EQM7_HUMAN;tr|C9JM82|C9JM82_HUMAN;tr|E7EPG2|E7EPG2_HUMAN;tr|B4DJ62|B4DJ62_HUMAN;tr|E7EX32|E7EX32_HUMAN;sp|Q99719|SEPT5_HUMAN;tr|G3XAH0|G3XAH0_HUMAN;tr|A0A087WWZ5|A0A087WWZ5_HUMAN",4100,"F8W9E5","F8W9E5_HUMAN",null,null,"SEPT5"]
[1,"15.8512","19.0509","13.6424","15.7294","19.0387",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;intracellular protein transport",null,"AP-type membrane coat adaptor complex;axon cytoplasm;clathrin adaptor complex;cytoplasmic vesicle membrane;Golgi apparatus","Lysosome",null,null,11,8,8,"44.3","37.1","37.1","46.977",0,"78.083",199260000,16,"0.291999",1,"-4.16943","-0.72153","sp|P53677|AP3M2_HUMAN;tr|E5RJ52|E5RJ52_HUMAN;tr|E7ER80|E7ER80_HUMAN;tr|H0YAY4|H0YAY4_HUMAN;tr|H0YBA0|H0YBA0_HUMAN;tr|E5RI83|E5RI83_HUMAN","sp|P53677|AP3M2_HUMAN;tr|E5RJ52|E5RJ52_HUMAN",1804,"P53677","AP3M2_HUMAN","AP-3 complex subunit mu-2",null,"AP3M2"]
["16.1517","16.2745",1,"15.3625","15.3889","15.4469",{"$nulls":3},"RNA secondary structure unwinding;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;membrane;nucleolus",{"$nulls":3},1,1,1,"2.4","2.4","2.4","72.456","0.0011769","3.274",12825000,3,"0.348309",1,"-4.25737","-0.839516","sp|Q8N8A6|DDX51_HUMAN","sp|Q8N8A6|DDX51_HUMAN",3433,"Q8N8A6","DDX51_HUMAN","ATP-dependent RNA helicase DDX51",null,"DDX51"]
["19.773",1,1,"18.185",1,"15.3877",{"$nulls":4},"RNA binding","nucleus","Ribosome biogenesis in eukaryotes;RNA transport",null,null,3,3,3,"20.2","20.2","20.2","17.631","0.00061602","4.0506",30974000,4,"0.2",1,"-4.26654","-0.519306","sp|Q8N5L8|RP25L_HUMAN","sp|Q8N5L8|RP25L_HUMAN",3416,"Q8N5L8","RP25L_HUMAN","Ribonuclease P protein subunit p25-like protein","Nase P protein subunit-like p25","RPP25L"]
["15.087",1,1,"14.6641","14.4235",1,{"$nulls":3},"B cell differentiation;cellular response to DNA damage stimulus;cellular response to UV;chromatin remodeling;DNA repair;innate immune response;mRNA transcription from RNA polymerase II promoter;negative regulation of transcription from RNA polymerase II promoter;positive regulation of natural killer cell differentiation;positive regulation of pro-T cell differentiation;positive regulation of T cell differentiation;positive regulation of T cell mediated immunity;protein homooligomerization;T cell differentiation in thymus;thymus development;translesion synthesis","DNA binding;K63-linked polyubiquitin modification-dependent protein binding;metal ion binding;protein heterodimerization activity;protein homodimerization activity","nuclear body;nuclear membrane;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"5.9","5.9","5.9","82.015",0,"27.45",72224000,11,"0.265767",1,"-4.33355","-0.66524","sp|Q9Y2K1|ZBTB1_HUMAN","sp|Q9Y2K1|ZBTB1_HUMAN",5227,"Q9Y2K1","ZBTB1_HUMAN","Zinc finger and BTB domain-containing protein 1",null,"ZBTB1"]
["16.6409",1,1,"16.2325","14.5105",1,{"$nulls":3},"cell cycle;cellular response to ATP;cellular response to DNA damage stimulus;cellular response to UV;DNA-templated transcription, initiation;midbrain development;negative regulation of gene expression;negative regulation of protein autoubiquitination;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of androgen receptor activity;positive regulation of cell proliferation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein binding;positive regulation of transcription from RNA polymerase I promoter;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription initiation from RNA polymerase II promoter;protein autophosphorylation;protein phosphorylation;protein polyubiquitination;protein stabilization;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of cell cycle G1/S phase transition;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage;regulation of transcription initiation from RNA polymerase II promoter;RNA polymerase II transcriptional preinitiation complex assembly;transcription elongation from RNA polymerase II promoter;transcription factor catabolic process;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;viral process","ATP binding;histone acetyltransferase activity;kinase activity;lysine-acetylated histone binding;p53 binding;protein heterodimerization activity;protein serine/threonine kinase activity;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly;sequence-specific DNA binding;TBP-class protein binding;transcription coactivator activity;transcription factor binding;ubiquitin conjugating enzyme activity","MLL1 complex;nuclear chromatin;nucleoplasm;nucleus;transcription factor complex;transcription factor TFIID complex","Basal transcription factors",null,null,12,12,12,"9.5","9.5","9.5","212.67",0,"39.2",185410000,31,"0.242885",1,"-4.36734","-0.615315","sp|P21675|TAF1_HUMAN;sp|Q8IZX4|TAF1L_HUMAN;tr|H0Y9L7|H0Y9L7_HUMAN;tr|H7BY98|H7BY98_HUMAN;tr|H7C2K9|H7C2K9_HUMAN","sp|P21675|TAF1_HUMAN;sp|Q8IZX4|TAF1L_HUMAN",1229,"P21675","TAF1_HUMAN","Transcription initiation factor TFIID subunit 1",null,"TAF1"]
["19.7231",1,"18.7178","18.0726","15.4066","19.129",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;calcium-mediated signaling using intracellular calcium source;cell communication by electrical coupling involved in cardiac conduction;cellular response to epinephrine stimulus;cellular response to glucagon stimulus;cellular response to glucose stimulus;cellular response to heat;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;high-density lipoprotein particle assembly;mRNA processing;peptidyl-serine phosphorylation;positive regulation of cell cycle arrest;protein phosphorylation;regulation of bicellular tight junction assembly;regulation of cardiac conduction;regulation of cardiac muscle contraction;regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;regulation of cytosolic calcium ion concentration;regulation of G2/M transition of mitotic cell cycle;regulation of heart rate;regulation of macroautophagy;regulation of osteoblast differentiation;regulation of proteasomal protein catabolic process;regulation of protein binding;regulation of ryanodine-sensitive calcium-release channel activity;renal water homeostasis;sperm capacitation;stimulatory C-type lectin receptor signaling pathway","ATP binding;cAMP-dependent protein kinase activity;protein kinase A regulatory subunit binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;ubiquitin protein ligase binding","acrosomal vesicle;calcium channel complex;cAMP-dependent protein kinase complex;centrosome;ciliary base;cytoplasm;cytosol;extracellular exosome;intercellular bridge;mitochondrion;motile cilium;nuclear speck;nucleoplasm;nucleotide-activated protein kinase complex;nucleus;perinuclear region of cytoplasm;plasma membrane raft;sperm midpiece","Adrenergic signaling in cardiomyocytes;Alcoholism;Aldosterone synthesis and secretion;Amoebiasis;Amphetamine addiction;Apelin signaling pathway;Autophagy - animal;Bile secretion;Calcium signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cortisol synthesis and secretion;Cushing syndrome;Dilated cardiomyopathy (DCM);Dopaminergic synapse;Endocrine and other factor-regulated calcium reabsorption;Endocrine resistance;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Hedgehog signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Inflammatory mediator regulation of TRP channels;Insulin secretion;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Morphine addiction;Olfactory transduction;Oocyte meiosis;Ovarian steroidogenesis;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Platelet activation;Prion diseases;Progesterone-mediated oocyte maturation;Proteoglycans in cancer;Ras signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Taste transduction;Thermogenesis;Thyroid hormone signaling pathway;Thyroid hormone synthesis;Tight junction;Vascular smooth muscle contraction;Vasopressin-regulated water reabsorption;Vibrio cholerae infection;Viral carcinogenesis;Wnt signaling pathway",null,null,7,3,3,"21.7","13.1","13.1","40.589",0,"15.12",105180000,10,"0.286666",1,"-4.38912","-0.710161","sp|P17612|KAPCA_HUMAN;tr|Q15136|Q15136_HUMAN;tr|K7ERP6|K7ERP6_HUMAN","sp|P17612|KAPCA_HUMAN",1159,"P17612","KAPCA_HUMAN","cAMP-dependent protein kinase catalytic subunit alpha","KA C-alpha","PRKACA"]
["16.7095","14.5604",1,"16.6298","13.7383","15.0872",{"$nulls":5},"WASH complex",{"$nulls":3},4,4,4,"5.2","5.2","5.2","117.06","0.0011959","3.5134",29273000,3,"0.368548",1,"-4.39514","-0.881133","tr|E7EQI7|E7EQI7_HUMAN;sp|Q12768|STRUM_HUMAN","tr|E7EQI7|E7EQI7_HUMAN;sp|Q12768|STRUM_HUMAN",2256,"E7EQI7","E7EQI7_HUMAN",null,null,"WASHC5"]
[1,"14.4786",1,1,"13.0785","15.7292",{"$nulls":3},"negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA catabolic process;RNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;membrane",{"$nulls":3},3,3,3,"5.5","5.5","5.5","128.12",0,"7.8349",24514000,5,"0.280116",1,"-4.44303","-0.696148","sp|Q14147|DHX34_HUMAN;tr|H7C504|H7C504_HUMAN","sp|Q14147|DHX34_HUMAN",2440,"Q14147","DHX34_HUMAN","Probable ATP-dependent RNA helicase DHX34",null,"DHX34"]
["17.6113",1,"17.6366","18.1477","14.004","17.6522",{"$nulls":3},"gastrulation;Golgi to plasma membrane protein transport;protein localization to Golgi apparatus;retrograde transport, endosome to Golgi;signal transduction;small GTPase mediated signal transduction","GTP binding;GTPase activity","cytosol;Golgi apparatus;membrane;trans-Golgi network;trans-Golgi network membrane",{"$nulls":3},2,2,2,9,9,9,"22.614",0,"6.3255",21697000,7,"0.326243",1,"-4.5187","-0.793694","sp|Q13795|ARFRP_HUMAN","sp|Q13795|ARFRP_HUMAN",2409,"Q13795","ARFRP_HUMAN","ADP-ribosylation factor-related protein 1","RF-related protein 1;RP","ARFRP1"]
["18.7814","16.0167",1,"19.0243","14.3206","16.0158",{"$nulls":4},"metal ion binding",{"$nulls":4},3,3,3,"24.4","24.4","24.4","21.754",0,"9.4357",20701000,1,"0.326445",1,"-4.52087","-0.794117","tr|A0A087WYF8|A0A087WYF8_HUMAN;tr|A0A0A0MQY0|A0A0A0MQY0_HUMAN;sp|Q53GG5|PDLI3_HUMAN;tr|D6RAF1|D6RAF1_HUMAN","tr|A0A087WYF8|A0A087WYF8_HUMAN;tr|A0A0A0MQY0|A0A0A0MQY0_HUMAN;sp|Q53GG5|PDLI3_HUMAN;tr|D6RAF1|D6RAF1_HUMAN",2778,"A0A087WYF8","A0A087WYF8_HUMAN",null,null,"PDLIM3"]
[1,"14.833","15.1623","15.912","14.2717","14.5114",{"$nulls":3},"cell differentiation","RNA binding",{"$nulls":4},4,4,4,"3.3","3.3","3.3","242.96",0,"11.338",38660000,11,"0.413656",1,"-4.56661","-0.972696","sp|Q5JSZ5|PRC2B_HUMAN;tr|H0Y412|H0Y412_HUMAN","sp|Q5JSZ5|PRC2B_HUMAN",2825,"Q5JSZ5","PRC2B_HUMAN","Protein PRRC2B",null,"PRRC2B"]
["17.768",1,"16.8894","17.6019","15.537","16.3465",{"$nulls":3},"G1/S transition of mitotic cell cycle;positive regulation of cell proliferation;positive regulation of protein kinase activity;protein ubiquitination involved in ubiquitin-dependent protein catabolic process","protein kinase binding;ubiquitin protein ligase binding","cullin-RING ubiquitin ligase complex",{"$nulls":3},1,1,1,"5.1","5.1","5.1","41.063","0.00061526","3.9938",13632000,3,"0.348952",1,"-4.60934","-0.840842","sp|Q86Y37|CACL1_HUMAN","sp|Q86Y37|CACL1_HUMAN",3262,"Q86Y37","CACL1_HUMAN","CDK2-associated and cullin domain-containing protein 1",null,"CACUL1"]
["18.6126","18.6967",1,"17.5696","17.5322","17.2492",{"$nulls":5},"integral component of membrane",{"$nulls":3},8,8,8,"12.5","12.5","12.5","93.159",0,"24.119",75985000,8,"0.326977",1,"-4.68055","-0.795227","tr|E7ER77|E7ER77_HUMAN;sp|Q7Z2K6|ERMP1_HUMAN;tr|A0A0C4DGF0|A0A0C4DGF0_HUMAN","tr|E7ER77|E7ER77_HUMAN;sp|Q7Z2K6|ERMP1_HUMAN",3143,"E7ER77","E7ER77_HUMAN",null,null,"ERMP1"]
[1,"13.3112","14.0996","14.9276","13.3599","14.2444",{"$nulls":9},2,2,2,"1.9","1.9","1.9","164.2","0.0011779","3.2838",24872000,6,"0.479227",1,"-4.70702","-1.10352","sp|A0JNW5|UH1BL_HUMAN;tr|A0A0C4DGH6|A0A0C4DGH6_HUMAN","sp|A0JNW5|UH1BL_HUMAN;tr|A0A0C4DGH6|A0A0C4DGH6_HUMAN",166,"A0JNW5","UH1BL_HUMAN","UHRF1-binding protein 1-like",null,"UHRF1BP1L"]
["17.7289","15.4751",1,"16.3422","15.0959","17.0011",{"$nulls":3},"innate immune response;interferon-gamma-mediated signaling pathway;negative regulation of viral entry into host cell;negative regulation of viral release from host cell;positive regulation of DNA binding transcription factor activity","DNA binding;metal ion binding;transferase activity;zinc ion binding","cytosol;nucleus",{"$nulls":3},5,5,5,"13.4","13.4","13.4","62.165",0,"10.288",20806000,4,"0.377898",1,"-4.74506","-0.90024","sp|Q12899|TRI26_HUMAN;tr|A2AE48|A2AE48_HUMAN;tr|A0A0G2JIW2|A0A0G2JIW2_HUMAN","sp|Q12899|TRI26_HUMAN;tr|A2AE48|A2AE48_HUMAN",2276,"Q12899","TRI26_HUMAN","Tripartite motif-containing protein 26",null,"TRIM26"]
[1,1,"16.4116","15.4135",1,"16.3552",{"$nulls":3},"metabolic process","ligase activity",{"$nulls":4},4,3,3,8,"5.9","5.9","58.586","0.00041719","4.3362",16074000,4,"0.267785",1,"-4.78573","-0.669607","tr|B7Z3Z9|B7Z3Z9_HUMAN;tr|E7EPM6|E7EPM6_HUMAN;sp|P33121|ACSL1_HUMAN;tr|H0Y9Z9|H0Y9Z9_HUMAN;tr|D6RER0|D6RER0_HUMAN","tr|B7Z3Z9|B7Z3Z9_HUMAN;tr|E7EPM6|E7EPM6_HUMAN;sp|P33121|ACSL1_HUMAN;tr|H0Y9Z9|H0Y9Z9_HUMAN;tr|D6RER0|D6RER0_HUMAN",1431,"B7Z3Z9","B7Z3Z9_HUMAN",null,null,"ACSL1"]
["18.7361","18.7735",1,"18.2704","17.9136","16.8416",{"$nulls":3},"cellular response to growth factor stimulus;cellular response to steroid hormone stimulus;negative regulation of intrinsic apoptotic signaling pathway;negative regulation of phosphatase activity;negative regulation of transcription from RNA polymerase II promoter;regulation of cell growth;regulation of transcription from RNA polymerase II promoter;response to virus;transcription, DNA-templated","chromatin binding;phosphatase inhibitor activity;phosphoprotein binding;protein phosphatase inhibitor activity;RNA polymerase II transcription corepressor activity","cytoplasm;cytosol;dendrite;DNA-directed RNA polymerase II, core complex;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"15.7","15.7","15.7","59.832",0,"16.121",100890000,9,"0.336682",1,"-4.83864","-0.815432","sp|O94763|RMP_HUMAN;tr|I3NI51|I3NI51_HUMAN;tr|I3L280|I3L280_HUMAN","sp|O94763|RMP_HUMAN",673,"O94763","RMP_HUMAN","Unconventional prefoldin RPB5 interactor 1",null,"URI1"]
[1,"15.9374","17.4775","16.2031","15.9381","16.8348",{"$nulls":9},2,2,2,"4.7","4.7","4.7","127.65","0.007705","2.3072",26790000,3,"0.388838",1,"-4.85368","-0.922508","tr|J3KNG9|J3KNG9_HUMAN;sp|P04920|B3A2_HUMAN","tr|J3KNG9|J3KNG9_HUMAN;sp|P04920|B3A2_HUMAN",886,"J3KNG9"]
[1,"16.3873",1,"16.629","15.3935",1,{"$nulls":3},"post-Golgi vesicle-mediated transport;protein folding;protein transport;visual perception","GTP binding;GTPase activator activity;unfolded protein binding","centriole;ciliary basal body;cilium;cytoplasm;cytoplasmic vesicle;extracellular exosome;Golgi apparatus;nuclear body;nucleoplasm;periciliary membrane compartment;plasma membrane",{"$nulls":3},2,2,2,"5.1","5.1","5.1","39.641","0.00042472","4.7179",12292000,3,"0.272588",1,"-4.87839","-0.67997","sp|O75695|XRP2_HUMAN","sp|O75695|XRP2_HUMAN",626,"O75695","XRP2_HUMAN","Protein XRP2",null,"RP2"]
["17.7245",1,"16.5388","18.1125","15.3863","16.476",{"$nulls":4},"ATP binding;nucleic acid binding;zinc ion binding","cytosol",{"$nulls":3},6,6,6,"10.4","10.4","10.4","82.612",0,"11.692",35542000,3,"0.378",1,"-4.90387","-0.900448","tr|A2A376|A2A376_HUMAN;sp|O95786|DDX58_HUMAN","tr|A2A376|A2A376_HUMAN;sp|O95786|DDX58_HUMAN",790,"A2A376","A2A376_HUMAN",null,null,"DDX58"]
["17.8597","16.5783",1,"16.0135","15.8898","18.2638",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","ligand-dependent nuclear receptor transcription coactivator activity;protein dimerization activity","nucleus",{"$nulls":3},3,3,3,"4.5","4.5","4.5","102.73","0.00021556","5.0695",129020000,6,"0.376295",1,"-4.90967","-0.89697","tr|E7EWM1|E7EWM1_HUMAN;sp|Q15596|NCOA2_HUMAN","tr|E7EWM1|E7EWM1_HUMAN;sp|Q15596|NCOA2_HUMAN",5508,"E7EWM1","E7EWM1_HUMAN",null,null,"NCOA2"]
["18.8798",1,"18.909","20.0872","15.5872","17.8937",{"$nulls":3},"regulation of phosphoprotein phosphatase activity;regulation of signal transduction","protein phosphatase inhibitor activity","cytosol;nucleoplasm",{"$nulls":3},2,2,2,"14.7","14.7","14.7","19.245","0.00042717","4.857",36866000,8,"0.332627",1,"-4.92646","-0.807002","tr|E7EMN6|E7EMN6_HUMAN;sp|Q6NXS1|IPP2M_HUMAN;sp|P41236|IPP2_HUMAN;tr|E7EUI7|E7EUI7_HUMAN","tr|E7EMN6|E7EMN6_HUMAN;sp|Q6NXS1|IPP2M_HUMAN;sp|P41236|IPP2_HUMAN;tr|E7EUI7|E7EUI7_HUMAN",1534,"E7EMN6","E7EMN6_HUMAN",null,null,"PPP1R2"]
["16.4378",1,1,"16.2526",1,"15.983",{"$nulls":3},"regulation of transcription, DNA-templated","RNA binding","cytosol",{"$nulls":3},2,2,2,"8.3","8.3","8.3","72.413","0.001004","3.6155",8641600,3,"0.274838",1,"-4.93261","-0.684815","tr|A0A087WZT0|A0A087WZT0_HUMAN;tr|A0A087WUK6|A0A087WUK6_HUMAN;tr|M0QZ22|M0QZ22_HUMAN;sp|Q5PRF9|SMAG2_HUMAN;tr|M0R0X3|M0R0X3_HUMAN","tr|A0A087WZT0|A0A087WZT0_HUMAN;tr|A0A087WUK6|A0A087WUK6_HUMAN;tr|M0QZ22|M0QZ22_HUMAN;sp|Q5PRF9|SMAG2_HUMAN;tr|M0R0X3|M0R0X3_HUMAN",2837,"A0A087WZT0","A0A087WZT0_HUMAN",null,null,"SAMD4B"]
[1,"14.4194","15.9085","16.5179","14.3606","15.3952",{"$nulls":3},"intracellular signal transduction;regulation of protein kinase A signaling","protein kinase A binding;protein phosphatase 1 binding","cytosol;microtubule organizing center;nucleolus;peroxisome;plasma membrane",{"$nulls":3},4,4,4,"4.9","4.9","4.9","210.51",0,"6.1493",30945000,9,"0.448201",1,"-4.98196","-1.0419","sp|Q9UKA4|AKA11_HUMAN","sp|Q9UKA4|AKA11_HUMAN",5083,"Q9UKA4","AKA11_HUMAN","A-kinase anchor protein 11","KAP-11","AKAP11"]
[1,"16.0167",1,"15.423","16.6704",1,{"$nulls":4},"ATP binding;protein tyrosine kinase collagen receptor activity","integral component of plasma membrane",{"$nulls":3},4,4,4,"5.3","5.3","5.3","85.467","0.00081733","3.9228",13513000,2,"0.285797",1,"-5.02554","-0.708307","tr|A0A0G2JNZ7|A0A0G2JNZ7_HUMAN;tr|A0A0A0MSX3|A0A0A0MSX3_HUMAN;sp|Q08345|DDR1_HUMAN;tr|H0Y9F4|H0Y9F4_HUMAN;tr|A0A0G2JI85|A0A0G2JI85_HUMAN;tr|E7EN94|E7EN94_HUMAN;tr|E7EVT1|E7EVT1_HUMAN;tr|E7ES06|E7ES06_HUMAN;tr|E7ETX3|E7ETX3_HUMAN;tr|E7EUD5|E7EUD5_HUMAN;tr|E7EVW6|E7EVW6_HUMAN;tr|E7ERN0|E7ERN0_HUMAN;tr|A0A0G2JHK4|A0A0G2JHK4_HUMAN;tr|E7ESR9|E7ESR9_HUMAN;tr|A2ABL0|A2ABL0_HUMAN;tr|E7ERI6|E7ERI6_HUMAN;tr|E7ETI3|E7ETI3_HUMAN;tr|A0A0G2JIA2|A0A0G2JIA2_HUMAN;tr|E7EPN2|E7EPN2_HUMAN;tr|H0Y717|H0Y717_HUMAN;tr|E7EUP7|E7EUP7_HUMAN;tr|A2ABL2|A2ABL2_HUMAN;tr|A0A0G2JIZ7|A0A0G2JIZ7_HUMAN;tr|E7EQ30|E7EQ30_HUMAN;tr|E7EPH4|E7EPH4_HUMAN;tr|A2ABM8|A2ABM8_HUMAN","tr|A0A0G2JNZ7|A0A0G2JNZ7_HUMAN;tr|A0A0A0MSX3|A0A0A0MSX3_HUMAN;sp|Q08345|DDR1_HUMAN;tr|H0Y9F4|H0Y9F4_HUMAN;tr|A0A0G2JI85|A0A0G2JI85_HUMAN",2228,"A0A0G2JNZ7","A0A0G2JNZ7_HUMAN",null,null,"DDR1"]
[1,"15.3136",1,"16.3771",1,"15.0371",{"$nulls":3},"carbohydrate metabolic process;fibroblast growth factor receptor signaling pathway;O-glycan processing;protein O-linked glycosylation via serine;protein O-linked glycosylation via threonine","calcium ion binding;carbohydrate binding;manganese ion binding;polypeptide N-acetylgalactosaminyltransferase activity","extracellular exosome;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;integral component of membrane;membrane;perinuclear region of cytoplasm","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,6,6,6,"12.5","12.5","12.5","72.609",0,"18.1",72827000,11,"0.298168",1,"-5.03356","-0.734634","sp|Q14435|GALT3_HUMAN;tr|C9J2C3|C9J2C3_HUMAN;tr|E7EUL0|E7EUL0_HUMAN","sp|Q14435|GALT3_HUMAN;tr|C9J2C3|C9J2C3_HUMAN;tr|E7EUL0|E7EUL0_HUMAN",2471,"Q14435","GALT3_HUMAN","Polypeptide N-acetylgalactosaminyltransferase 3",null,"GALNT3"]
[1,"15.0187",1,1,"15.0758","16.1166",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"7.2","7.2","7.2","53.946","0.0010075","3.6654",5863200,2,"0.304967",1,"-5.05789","-0.749021","tr|C9J519|C9J519_HUMAN;tr|E7EN73|E7EN73_HUMAN;sp|Q8IZA0|K319L_HUMAN;tr|B1AN15|B1AN15_HUMAN","tr|C9J519|C9J519_HUMAN;tr|E7EN73|E7EN73_HUMAN;sp|Q8IZA0|K319L_HUMAN;tr|B1AN15|B1AN15_HUMAN",3354,"C9J519","C9J519_HUMAN",null,null,"KIAA0319L"]
[1,"18.8719","19.1766","17.3982","18.5206","18.4067",{"$nulls":3},"negative regulation of cell aging;positive regulation of mitochondrial fission;protein autoubiquitination;protein localization to mitochondrion;protein polyubiquitination;regulation of mitochondrial fission","GTPase binding;ubiquitin-protein transferase activity;zinc ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;mitochondrial outer membrane;mitochondrion",{"$nulls":3},2,2,2,"9.7","9.7","9.7","31.231",0,"8.8406",44576000,3,"0.351455",1,"-5.09237","-0.846009","sp|Q9NX47|MARH5_HUMAN","sp|Q9NX47|MARH5_HUMAN",4812,"Q9NX47","MARH5_HUMAN","E3 ubiquitin-protein ligase MARCH5",null,"MARCH5"]
[1,"17.4553",1,"17.0217","16.7326",1,{"$nulls":4},"actin binding;protein phosphatase inhibitor activity",{"$nulls":4},1,1,1,"2.4","2.4","2.4","68.295","0.001007","3.6499",19411000,3,"0.267518",1,"-5.09968","-0.669029","tr|J3KP75|J3KP75_HUMAN;sp|O75167|PHAR2_HUMAN","tr|J3KP75|J3KP75_HUMAN;sp|O75167|PHAR2_HUMAN",554,"J3KP75","J3KP75_HUMAN","Phosphatase and actin regulator {ECO:0000256|RuleBase:RU301113}",null,"PHACTR2"]
["17.8717",1,1,"18.2217","15.9818",1,{"$nulls":3},"cell proliferation in midbrain;embryonic nail plate morphogenesis;establishment of body hair planar orientation;hair follicle development;inner ear morphogenesis;midbrain morphogenesis;negative regulation of canonical Wnt signaling pathway;negative regulation of DNA binding transcription factor activity;neural tube closure;non-canonical Wnt signaling pathway;platelet activation;Wnt signaling pathway, calcium modulating pathway;Wnt signaling pathway, planar cell polarity pathway","G-protein coupled receptor activity;ubiquitin protein ligase binding;Wnt-activated receptor activity;Wnt-protein binding","apical plasma membrane;apicolateral plasma membrane;cell surface;cytoplasmic vesicle membrane;integral component of membrane;integral component of plasma membrane;plasma membrane","Basal cell carcinoma;Breast cancer;Cushing syndrome;Gastric cancer;Hepatocellular carcinoma;Hippo signaling pathway;Human papillomavirus infection;Melanogenesis;mTOR signaling pathway;Pathways in cancer;Proteoglycans in cancer;Signaling pathways regulating pluripotency of stem cells;Wnt signaling pathway",null,null,5,5,5,"10.6","10.6","10.6","79.291",0,"14.271",121340000,13,"0.261105",1,"-5.11063","-0.655136","sp|O60353|FZD6_HUMAN;tr|E5RJG0|E5RJG0_HUMAN;tr|G5EA13|G5EA13_HUMAN","sp|O60353|FZD6_HUMAN",491,"O60353","FZD6_HUMAN","Frizzled-6","Fz6;z-6","FZD6"]
["18.2507",1,"18.2268","18.4944","16.213","18.1988",{"$nulls":3},"DNA repair","double-stranded DNA binding;RNA binding;single-stranded DNA binding","nucleus",{"$nulls":3},1,1,1,"6.4","6.4","6.4","26.432","0.0010034","3.6027",18817000,6,"0.37197",1,"-5.14293","-0.888134","tr|F5H1Y0|F5H1Y0_HUMAN;tr|H0YGT5|H0YGT5_HUMAN;sp|Q96B01|R51A1_HUMAN","tr|F5H1Y0|F5H1Y0_HUMAN;tr|H0YGT5|H0YGT5_HUMAN;sp|Q96B01|R51A1_HUMAN",3797,"F5H1Y0","F5H1Y0_HUMAN",null,null,"RAD51AP1"]
[1,1,"17.0583",1,"16.9973","16.4939",{"$nulls":3},"intracellular pH reduction;protein transport;regulation of ion transmembrane transport","voltage-gated anion channel activity","Golgi cisterna membrane;integral component of membrane",{"$nulls":3},2,2,2,"5.5","5.5","5.5","52.916","0.00081218","3.8174",18606000,2,"0.275431",1,"-5.14432","-0.686088","sp|P0CG08|GPHRB_HUMAN;sp|B7ZAQ6|GPHRA_HUMAN;tr|A0A087WW78|A0A087WW78_HUMAN;tr|A0A087WW82|A0A087WW82_HUMAN;tr|U3KPV2|U3KPV2_HUMAN;tr|E9PKY3|E9PKY3_HUMAN","sp|P0CG08|GPHRB_HUMAN;sp|B7ZAQ6|GPHRA_HUMAN;tr|A0A087WW78|A0A087WW78_HUMAN;tr|A0A087WW82|A0A087WW82_HUMAN;tr|U3KPV2|U3KPV2_HUMAN;tr|E9PKY3|E9PKY3_HUMAN",195,"P0CG08","GPHRB_HUMAN","Golgi pH regulator B",null,"GPR89B"]
["17.9417","16.4746",1,"18.1186","16.0719","16.6604",{"$nulls":5},"intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},4,4,4,"13.9","13.9","13.9","69.548",0,"6.3662",33442000,6,"0.399159",1,"-5.14484","-0.943431","tr|H0Y517|H0Y517_HUMAN;tr|H7C1U3|H7C1U3_HUMAN;sp|Q5T0F9|C2D1B_HUMAN","tr|H0Y517|H0Y517_HUMAN;tr|H7C1U3|H7C1U3_HUMAN;sp|Q5T0F9|C2D1B_HUMAN",5560,"H0Y517","H0Y517_HUMAN",null,null,"CC2D1B"]
[1,"14.6426","14.1017","15.4551","15.2068","14.5435",{"$nulls":3},"axon development;microtubule cytoskeleton organization;regulation of dendrite development;regulation of Golgi organization;regulation of microtubule polymerization;regulation of organelle organization","calmodulin binding;microtubule minus-end binding;spectrin binding","cytosol;Golgi apparatus;microtubule end",{"$nulls":3},4,4,4,"4.6","4.6","4.6","168.09",0,"15.24",50238000,14,"0.504469",1,"-5.15369","-1.15336","sp|Q08AD1|CAMP2_HUMAN;tr|H0Y4Z1|H0Y4Z1_HUMAN","sp|Q08AD1|CAMP2_HUMAN",2239,"Q08AD1","CAMP2_HUMAN","Calmodulin-regulated spectrin-associated protein 2 {ECO:0000305}",null,"CAMSAP2"]
["16.6541",1,1,"16.7342",1,"16.3951",{"$nulls":3},"intracellular mRNA localization;mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;regulation of translation;RNA export from nucleus;termination of RNA polymerase II transcription","enzyme binding;identical protein binding;RNA binding;ubiquitin protein ligase binding","cytosol;exon-exon junction complex;intracellular ribonucleoprotein complex;nuclear membrane;nuclear speck;nucleoplasm;perinuclear region of cytoplasm","mRNA surveillance pathway;RNA transport",null,null,1,1,1,"3.6","3.6","3.6","76.277","0.00041589","4.2684",11536000,3,"0.282364",1,"-5.15841","-0.700965","sp|O15234|CASC3_HUMAN","sp|O15234|CASC3_HUMAN",351,"O15234","CASC3_HUMAN","Protein CASC3",null,"CASC3"]
["15.6842",1,"14.9228","17.3452","13.8217","15.9234",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA processing","snoRNA binding","nucleolus;nucleoplasm;Pwp2p-containing subcomplex of 90S preribosome;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,8,8,8,"16.9","16.9","16.9","70.193",0,"27.659",101730000,20,"0.455931",1,"-5.16109","-1.0573","sp|Q9NYH9|UTP6_HUMAN;tr|J3KRR8|J3KRR8_HUMAN","sp|Q9NYH9|UTP6_HUMAN",4851,"Q9NYH9","UTP6_HUMAN","U3 small nucleolar RNA-associated protein 6 homolog",null,"UTP6"]
["17.168",1,1,"16.1763","17.4816",1,{"$nulls":3},"apoptotic process;negative regulation of apoptotic process",null,"endomembrane system;intracellular;membrane",{"$nulls":3},1,1,1,3,3,3,"38.506","0.0028425","2.7835",15298000,1,"0.274337",1,"-5.16328","-0.683735","sp|Q9NQS1|AVEN_HUMAN","sp|Q9NQS1|AVEN_HUMAN",4659,"Q9NQS1","AVEN_HUMAN","Cell death regulator Aven",null,"AVEN"]
[1,1,"16.9113",1,"16.3651","17.0517",{"$nulls":3},"apoptotic process",{"$nulls":5},1,1,1,"4.4","4.4","4.4","38.367",0,"8.9997",41363000,8,"0.278756",1,"-5.16848","-0.693232","sp|Q9H8G2|CAAP1_HUMAN","sp|Q9H8G2|CAAP1_HUMAN",4518,"Q9H8G2","CAAP1_HUMAN","Caspase activity and apoptosis inhibitor 1",null,"CAAP1"]
["16.437","14.0451",1,"16.7467","14.8758","15.4084",{"$nulls":3},"apoptotic process;blood coagulation;cell migration;cytoskeleton organization;Fc-gamma receptor signaling pathway involved in phagocytosis;integrin-mediated signaling pathway;phagocytosis, engulfment;positive regulation of epithelial cell migration;positive regulation of substrate adhesion-dependent cell spreading;signal transduction;small GTPase mediated signal transduction;vascular endothelial growth factor receptor signaling pathway","GTPase activator activity;Rho guanyl-nucleotide exchange factor activity;SH3 domain binding","cytoplasm;cytosol;guanyl-nucleotide exchange factor complex;membrane","Bacterial invasion of epithelial cells;Focal adhesion;Regulation of actin cytoskeleton;Shigellosis;Yersinia infection",null,null,15,15,14,11,11,"10.5","215.34",0,"27.769",112610000,20,"0.463964",1,"-5.18296","-1.07327","sp|Q14185|DOCK1_HUMAN;tr|A0A096LNH6|A0A096LNH6_HUMAN","sp|Q14185|DOCK1_HUMAN;tr|A0A096LNH6|A0A096LNH6_HUMAN",2449,"Q14185","DOCK1_HUMAN","Dedicator of cytokinesis protein 1",null,"DOCK1"]
[1,"15.5307",1,"16.9022",1,"15.1994",{"$nulls":3},"histone H3 acetylation;transcription from RNA polymerase II promoter","DNA binding transcription factor activity;transcription coactivator activity","cytoplasmic ribonucleoprotein granule;nuclear speck;nucleus;STAGA complex;transcription factor TFTC complex","Basal transcription factors",null,null,8,8,8,"20.2","20.2","20.2","66.155",0,"67.069",238230000,30,"0.301858",1,"-5.19032","-0.742449","sp|O75529|TAF5L_HUMAN","sp|O75529|TAF5L_HUMAN",602,"O75529","TAF5L_HUMAN","TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L",null,"TAF5L"]
["18.7278",1,"18.3555","18.8541","17.5392","17.2708",{"$nulls":3},"cellular response to interferon-gamma;intracellular protein transport;regulation of macroautophagy;retrograde transport, endosome to Golgi","protein transporter activity","cytosol;early endosome;endosome;late endosome;phagocytic vesicle;retromer complex;retromer, cargo-selective complex","Endocytosis",null,null,5,4,4,"17.9","15.8","15.8","39.154",0,"8.7298",69647000,5,"0.370429",1,"-5.19363","-0.884984","sp|Q4G0F5|VP26B_HUMAN;tr|A0A0D9SFQ6|A0A0D9SFQ6_HUMAN;tr|H0YCI7|H0YCI7_HUMAN","sp|Q4G0F5|VP26B_HUMAN",2753,"Q4G0F5","VP26B_HUMAN","Vacuolar protein sorting-associated protein 26B",null,"VPS26B"]
[1,"15.8809","15.1429","16.0616","15.7318","15.8185",{"$nulls":3},"embryo implantation;nucleologenesis;positive regulation of gene expression, epigenetic;rRNA transcription;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription initiation from RNA polymerase I promoter","DNA binding;DNA-directed 5'-3' RNA polymerase activity;metal ion binding;ribonucleoside binding","cytosol;DNA-directed RNA polymerase I complex;nucleolus;nucleoplasm","RNA polymerase",null,null,14,14,14,"14.4","14.4","14.4","128.23",0,"28.491",160440000,28,"0.463776",1,"-5.19601","-1.07289","sp|Q9H9Y6|RPA2_HUMAN;tr|C9JS83|C9JS83_HUMAN;tr|H7C0D9|H7C0D9_HUMAN;tr|C9JJG2|C9JJG2_HUMAN;tr|F8WDS4|F8WDS4_HUMAN;tr|F8WAK7|F8WAK7_HUMAN;tr|F8WBB9|F8WBB9_HUMAN;tr|F8WCS3|F8WCS3_HUMAN","sp|Q9H9Y6|RPA2_HUMAN",4551,"Q9H9Y6","RPA2_HUMAN","DNA-directed RNA polymerase I subunit RPA2","NA polymerase I subunit 2","POLR1B"]
[1,"15.2533",1,"15.7155","16.1293",1,{"$nulls":3},"long-chain fatty acid transport;very long-chain fatty acid metabolic process","fatty acid transmembrane transporter activity;long-chain fatty acid-CoA ligase activity;nucleotide binding;very long-chain fatty acid-CoA ligase activity","integral component of membrane;plasma membrane;sarcolemma","Insulin resistance;PPAR signaling pathway",null,null,3,3,3,"5.5","5.5","5.5","70.111",0,"5.9265",41130000,7,"0.30801",1,"-5.19717","-0.755444","sp|Q9Y2P4|S27A6_HUMAN;tr|D6RAJ2|D6RAJ2_HUMAN","sp|Q9Y2P4|S27A6_HUMAN",5230,"Q9Y2P4","S27A6_HUMAN","Long-chain fatty acid transport protein 6","ATP-6;atty acid transport protein 6","SLC27A6"]
[1,1,"16.0076","17.0968",1,"15.537",{"$nulls":3},"cellular biogenic amine metabolic process;dopamine catabolic process;neurotransmitter catabolic process;neurotransmitter metabolic process","primary amine oxidase activity","integral component of membrane;mitochondrial outer membrane;mitochondrion","Alcoholism;Amphetamine addiction;Arginine and proline metabolism;Cocaine addiction;Dopaminergic synapse;Drug metabolism - cytochrome P450;Glycine, serine and threonine metabolism;Histidine metabolism;Metabolic pathways;Phenylalanine metabolism;Serotonergic synapse;Tryptophan metabolism;Tyrosine metabolism",null,null,2,1,1,"4.2","2.1","2.1","59.681","0.0048562","2.5715",8167200,3,"0.294695",1,"-5.20873","-0.727263","sp|P21397|AOFA_HUMAN","sp|P21397|AOFA_HUMAN",1225,"P21397","AOFA_HUMAN","Amine oxidase [flavin-containing] A",null,"MAOA"]
[1,"13.5597","15.6341","17.2631","13.5196","15.0429",{"$nulls":3},"cellular response to cycloheximide;cellular response to puromycin;histone mRNA catabolic process;negative regulation of telomere maintenance via telomerase;negative regulation of translation;nuclear mRNA surveillance;nuclear-transcribed mRNA catabolic process;regulation of mRNA stability;response to testosterone;RNA phosphodiester bond hydrolysis, exonucleolytic;rRNA catabolic process","5'-3' exoribonuclease activity;G-quadruplex DNA binding;G-quadruplex RNA binding;RNA binding;telomerase RNA binding","cytosol;dendrite;membrane;neuronal cell body;nucleus;P-body;plasma membrane;synapse","Ribosome biogenesis in eukaryotes;RNA degradation",null,null,8,8,8,"6.1","6.1","6.1","194.1",0,"9.4883",42706000,8,"0.48192",1,"-5.21061","-1.10885","sp|Q8IZH2|XRN1_HUMAN;tr|H7C5E4|H7C5E4_HUMAN","sp|Q8IZH2|XRN1_HUMAN;tr|H7C5E4|H7C5E4_HUMAN",3356,"Q8IZH2","XRN1_HUMAN","5'-3' exoribonuclease 1",null,"XRN1"]
["16.7744",1,1,"17.3239",1,"16.1044",{"$nulls":4},"DNA binding;heme binding;metal ion binding;protein homodimerization activity",{"$nulls":4},4,4,4,"10.4","10.4","10.4","62.889",0,"9.7178",35119000,11,"0.282966",1,"-5.21793","-0.702252","sp|Q8WY91|THAP4_HUMAN","sp|Q8WY91|THAP4_HUMAN",3652,"Q8WY91","THAP4_HUMAN","THAP domain-containing protein 4",null,"THAP4"]
[1,"16.0668","17.4252","16.7994","15.1193","18.2587",{"$nulls":3},"cellular response to hydrogen peroxide;histone ubiquitination;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell proliferation;positive regulation of collagen biosynthetic process;positive regulation of DNA repair;transcription, DNA-templated","methylated histone binding;single-stranded RNA binding;ubiquitin-protein transferase activator activity","heterochromatin;nuclear chromatin;nucleoplasm;nucleus;PcG protein complex;PRC1 complex",{"$nulls":3},5,5,5,19,19,19,"43.395",0,"17.016",110740000,20,"0.416763",1,"-5.22846","-0.978951","sp|Q9HC52|CBX8_HUMAN;tr|C9J6K3|C9J6K3_HUMAN;tr|C9JM54|C9JM54_HUMAN","sp|Q9HC52|CBX8_HUMAN;tr|C9J6K3|C9J6K3_HUMAN",4586,"Q9HC52","CBX8_HUMAN","Chromobox protein homolog 8",null,"CBX8"]
["14.9866","15.0005",1,"14.6721","15.7103","16.3076",{"$nulls":9},3,3,3,"3.5","3.5","3.5","133.11",0,"9.6674",70296000,9,"0.48569",1,"-5.23429","-1.11631","tr|A0A087WUH0|A0A087WUH0_HUMAN;sp|P28715|ERCC5_HUMAN;tr|R4GMW8|R4GMW8_HUMAN","tr|A0A087WUH0|A0A087WUH0_HUMAN;sp|P28715|ERCC5_HUMAN;tr|R4GMW8|R4GMW8_HUMAN",1346,"A0A087WUH0"]
[1,"16.8863","16.5129","16.361","16.7884","16.9529",{"$nulls":3},"intra-Golgi vesicle-mediated transport;protein transport",null,"Golgi membrane;Golgi transport complex",{"$nulls":3},5,5,5,"14.2","14.2","14.2","60.438",0,"16.712",27396000,4,"0.426962",1,"-5.23433","-0.999435","tr|H3BQV3|H3BQV3_HUMAN;sp|Q96MW5|COG8_HUMAN;tr|A0A087X1T3|A0A087X1T3_HUMAN;tr|H3BSH5|H3BSH5_HUMAN;tr|H3BMQ9|H3BMQ9_HUMAN;tr|H3BUN2|H3BUN2_HUMAN","tr|H3BQV3|H3BQV3_HUMAN;sp|Q96MW5|COG8_HUMAN",3979,"H3BQV3","H3BQV3_HUMAN","Conserved oligomeric Golgi complex subunit 8 {ECO:0000256|PIRNR:PIRNR015415}","OG complex subunit 8 {ECO:0000256|PIRNR:PIRNR015415}","COG8"]
[1,"17.3434","17.8292","16.3286","17.9529","17.6053",{"$nulls":3},"cell cycle arrest;cell differentiation;cell migration;cellular response to morphine;filopodium assembly;modulation of chemical synaptic transmission;negative regulation of cell growth;nervous system development;regulation of cell growth by extracellular stimulus;regulation of cell proliferation;regulation of exit from mitosis;regulation of opioid receptor signaling pathway;RNA splicing","actin binding;protein phosphatase 1 binding;protein phosphatase inhibitor activity","adherens junction;cytoplasm;cytoskeleton;dendritic spine;filopodium;lamellipodium;nucleoplasm;plasma membrane;protein phosphatase type 1 complex;ruffle membrane",{"$nulls":3},2,2,2,"2.6","2.6","2.6","89.191",0,"6.2577",54028000,4,"0.399125",1,"-5.23807","-0.943363","sp|Q96SB3|NEB2_HUMAN;tr|D3DTX6|D3DTX6_HUMAN","sp|Q96SB3|NEB2_HUMAN;tr|D3DTX6|D3DTX6_HUMAN",4037,"Q96SB3","NEB2_HUMAN","Neurabin-2",null,"PPP1R9B"]
["18.61","16.323",1,"17.8139","16.9662","16.8911",{"$nulls":3},"cytoskeleton organization;negative regulation of axon extension;negative regulation of cell migration;negative regulation of fibroblast migration;regulation of small GTPase mediated signal transduction;Rho protein signal transduction","GTPase activator activity;identical protein binding;Rac GTPase binding;SH3/SH2 adaptor activity","cytoplasm;cytosol;Golgi apparatus;growth cone;microtubule",{"$nulls":3},13,13,13,"19.8","19.8","19.8","105.02",0,"21.796",100680000,14,"0.401206",1,"-5.24606","-0.947572","sp|P98171|RHG04_HUMAN;tr|E7EQN5|E7EQN5_HUMAN;tr|E9PCM6|E9PCM6_HUMAN;tr|A0A0B4J1X7|A0A0B4J1X7_HUMAN;tr|S4R352|S4R352_HUMAN;tr|S4R314|S4R314_HUMAN;tr|C9JLA8|C9JLA8_HUMAN;tr|C9J5M2|C9J5M2_HUMAN;tr|H7C3G3|H7C3G3_HUMAN;tr|H7C2Z8|H7C2Z8_HUMAN;tr|H7C120|H7C120_HUMAN;tr|F8WAR0|F8WAR0_HUMAN;tr|H7C3K8|H7C3K8_HUMAN","sp|P98171|RHG04_HUMAN;tr|E7EQN5|E7EQN5_HUMAN;tr|E9PCM6|E9PCM6_HUMAN;tr|A0A0B4J1X7|A0A0B4J1X7_HUMAN",2106,"P98171","RHG04_HUMAN","Rho GTPase-activating protein 4 {ECO:0000305}",null,"ARHGAP4"]
["13.6607",1,1,"14.7991",1,"15.6126",{"$nulls":9},3,3,3,"4.3","4.3","4.3","148.86",0,"11.345",4944300,2,"0.342344",1,"-5.25034","-0.827176","tr|G3V198|G3V198_HUMAN;sp|Q12769|NU160_HUMAN;tr|E9PR16|E9PR16_HUMAN","tr|G3V198|G3V198_HUMAN;sp|Q12769|NU160_HUMAN",2257,"G3V198","G3V198_HUMAN",null,null,"NUP160"]
["16.6566","16.6618",1,"17.4802","16.5732","16.0463",{"$nulls":3},"activation of MAPK activity;activation of MAPKK activity;activation of NF-kappaB-inducing kinase activity;anoikis;Fc-epsilon receptor signaling pathway;histone H3 acetylation;I-kappaB kinase/NF-kappaB signaling;I-kappaB phosphorylation;JNK cascade;MyD88-dependent toll-like receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interleukin-2 production;positive regulation of JUN kinase activity;positive regulation of macroautophagy;positive regulation of NF-kappaB transcription factor activity;positive regulation of T cell activation;positive regulation of T cell cytokine production;protein deubiquitination;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;transcription, DNA-templated;transforming growth factor beta receptor signaling pathway;viral process;Wnt signaling pathway, calcium modulating pathway","ATP binding;identical protein binding;magnesium ion binding;MAP kinase kinase kinase activity;protein kinase activity;protein serine/threonine kinase activity;scaffold protein binding","Ada2/Gcn5/Ada3 transcription activator complex;cytosol;endosome membrane;nucleus;plasma membrane","Adherens junction;AMPK signaling pathway;Autophagy - animal;Epstein-Barr virus infection;Fluid shear stress and atherosclerosis;Hepatitis B;Herpes simplex virus 1 infection;Human immunodeficiency virus 1 infection;IL-17 signaling pathway;Leishmaniasis;MAPK signaling pathway;Measles;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Osteoclast differentiation;RIG-I-like receptor signaling pathway;T cell receptor signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Wnt signaling pathway;Yersinia infection",null,null,3,3,3,"8.4","8.4","8.4","67.195",0,"9.2144",37133000,5,"0.429525",1,"-5.26046","-1.00457","sp|O43318|M3K7_HUMAN;tr|Q9UG54|Q9UG54_HUMAN","sp|O43318|M3K7_HUMAN;tr|Q9UG54|Q9UG54_HUMAN",408,"O43318","M3K7_HUMAN","Mitogen-activated protein kinase kinase kinase 7",null,"MAP3K7"]
[1,1,"15.0655","16.7169",1,"15.1357",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K11-linked ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of mitotic metaphase/anaphase transition;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle","protein phosphatase binding;ubiquitin-protein transferase activity","anaphase-promoting complex;cytosol;nucleoplasm;nucleus","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis",null,null,2,2,2,"3.5","3.5","3.5","92.115","0.0011749","3.2635",6586300,1,"0.313994",1,"-5.26235","-0.768039","sp|Q9UJX5|APC4_HUMAN;tr|D6RFM7|D6RFM7_HUMAN;tr|D6RAP6|D6RAP6_HUMAN","sp|Q9UJX5|APC4_HUMAN;tr|D6RFM7|D6RFM7_HUMAN;tr|D6RAP6|D6RAP6_HUMAN",5070,"Q9UJX5","APC4_HUMAN","Anaphase-promoting complex subunit 4","PC4","ANAPC4"]
["21.0744","17.979",1,"20.9694","18.0933","16.7928",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,1,1,"6.8",3,3,"38.254","0.000429","4.9844",188290000,10,"0.342793",1,"-5.26735","-0.828106","tr|Q8MH48|Q8MH48_HUMAN;sp|P17693|HLAG_HUMAN;tr|Q5RJ85|Q5RJ85_HUMAN;tr|A0A0G2JPQ3|A0A0G2JPQ3_HUMAN","tr|Q8MH48|Q8MH48_HUMAN;sp|P17693|HLAG_HUMAN;tr|Q5RJ85|Q5RJ85_HUMAN;tr|A0A0G2JPQ3|A0A0G2JPQ3_HUMAN",1161,"Q8MH48","Q8MH48_HUMAN"]
["16.3701","14.6733",1,"17.6398","14.7814","15.4772",{"$nulls":4},"microtubule motor activity","cytoplasm;kinesin complex;microtubule","Salmonella infection",null,null,9,4,4,"17.9","9.9","9.9","68.639",0,"13.682",30044000,6,"0.46215",1,"-5.28501","-1.06966","sp|Q9NSK0|KLC4_HUMAN;tr|C9JZE5|C9JZE5_HUMAN;tr|C9J8T5|C9J8T5_HUMAN;tr|H7C4M1|H7C4M1_HUMAN","sp|Q9NSK0|KLC4_HUMAN",4715,"Q9NSK0","KLC4_HUMAN","Kinesin light chain 4","LC 4","KLC4"]
["20.2266",1,"20.7698","21.3054","15.3566","21.2068",{"$nulls":4},"kinase activity;magnesium ion binding;potassium ion binding;pyruvate kinase activity","cytosol",{"$nulls":3},33,3,0,"70.5","7.8",0,"53.045",0,"28.957",363720000,16,"0.319193",1,"-5.29081","-0.778948","tr|H3BTN5|H3BTN5_HUMAN","tr|H3BTN5|H3BTN5_HUMAN",5575,"H3BTN5","H3BTN5_HUMAN","Pyruvate kinase {ECO:0000256|RuleBase:RU000504}",null,"PKM"]
["16.1175","15.0403",1,"16.4076","15.4393","16.2127",{"$nulls":4},"endonuclease activity;metal ion binding;nucleic acid binding","nucleus",{"$nulls":3},4,4,4,"8.2","8.2","8.2","71.514",0,"5.5004",63468000,5,"0.470639",1,"-5.3006","-1.08651","tr|F5GYN7|F5GYN7_HUMAN;sp|Q5FWF4|ZRAB3_HUMAN","tr|F5GYN7|F5GYN7_HUMAN;sp|Q5FWF4|ZRAB3_HUMAN",2809,"F5GYN7","F5GYN7_HUMAN"]
[1,"16.135",1,"16.8208","16.2174",1,{"$nulls":3},"endocytosis;protein transport","GTPase activator activity;guanyl-nucleotide exchange factor activity","actin cytoskeleton;cytoplasmic vesicle;ruffle",{"$nulls":3},1,1,1,"2.5","2.5","2.5","62.466","0.00061538","4.0016",13200000,1,"0.297595",1,"-5.30108","-0.733419","sp|Q6ZS11|RINL_HUMAN","sp|Q6ZS11|RINL_HUMAN",3084,"Q6ZS11","RINL_HUMAN","Ras and Rab interactor-like protein",null,"RINL"]
["17.4479","16.8727",1,"18.7134","16.2815","16.2867",{"$nulls":4},"ATP binding","extracellular exosome",{"$nulls":3},10,10,10,"21.2","21.2","21.2","74.977",0,"30.205",85256000,16,"0.415419",1,"-5.32036","-0.976246","sp|O43301|HS12A_HUMAN;tr|K7ELE6|K7ELE6_HUMAN;tr|K7ENF6|K7ENF6_HUMAN","sp|O43301|HS12A_HUMAN",405,"O43301","HS12A_HUMAN","Heat shock 70 kDa protein 12A",null,"HSPA12A"]
["16.2029",1,1,"16.59",1,"16.5779",{"$nulls":3},"protein homooligomerization;protein processing;proteolysis;regulation of fatty acid beta-oxidation","identical protein binding;protease binding;serine-type endopeptidase activity","membrane;peroxisome",{"$nulls":3},1,1,1,"3.5","3.5","3.5","59.308","0.00041186","4.1093",9183300,1,"0.297541",1,"-5.32166","-0.733304","sp|Q2T9J0|TYSD1_HUMAN","sp|Q2T9J0|TYSD1_HUMAN",2720,"Q2T9J0","TYSD1_HUMAN","Peroxisomal leader peptide-processing protease",null,"TYSND1"]
["19.2645","16.9763",1,"18.8877","17.2059","17.1217",{"$nulls":3},"snRNA transcription from RNA polymerase II promoter",null,"nucleoplasm",{"$nulls":3},7,7,7,"22.6","22.6","22.6","57.47",0,"21.473",62475000,16,"0.38872",1,"-5.32483","-0.922267","sp|Q96SY0|VWA9_HUMAN;tr|B4DJL6|B4DJL6_HUMAN;tr|B4DVT3|B4DVT3_HUMAN;tr|H3BRY6|H3BRY6_HUMAN;tr|H3BP17|H3BP17_HUMAN;tr|H3BMK7|H3BMK7_HUMAN","sp|Q96SY0|VWA9_HUMAN;tr|B4DJL6|B4DJL6_HUMAN;tr|B4DVT3|B4DVT3_HUMAN;tr|H3BRY6|H3BRY6_HUMAN",4045,"Q96SY0","INT14_HUMAN","Integrator complex subunit 14 {ECO:0000312|HGNC:HGNC:25372}",null,"INTS14"]
[1,"13.9661","14.8667","16.7279","14.0567","15.051",{"$nulls":3},"DNA damage checkpoint","ATP binding;eukaryotic translation initiation factor 2alpha kinase activity",{"$nulls":4},3,3,3,"2.9","2.9","2.9","161.12","0.00042185","4.5925",20842000,3,"0.514517",1,"-5.33423","-1.17313","tr|H0YME5|H0YME5_HUMAN;sp|Q9P2K8|E2AK4_HUMAN","tr|H0YME5|H0YME5_HUMAN;sp|Q9P2K8|E2AK4_HUMAN",4936,"H0YME5","H0YME5_HUMAN",null,null,"EIF2AK4"]
[1,"16.8745","17.384","17.453","16.4235","17.4143",{"$nulls":3},"tRNA splicing, via endonucleolytic cleavage and ligation","tRNA-intron endonuclease activity","centrosome;cytosol;nucleoplasm;tRNA-intron endonuclease complex",{"$nulls":3},1,1,1,"2.9","2.9","2.9","43.174","0.00042808","4.923",27048000,1,"0.423095",1,"-5.3441","-0.991676","tr|C9J7Z4|C9J7Z4_HUMAN;sp|Q8NCE0|SEN2_HUMAN","tr|C9J7Z4|C9J7Z4_HUMAN;sp|Q8NCE0|SEN2_HUMAN",3472,"C9J7Z4","C9J7Z4_HUMAN",null,null,"TSEN2"]
["18.5165",1,1,"18.7054","16.8465",1,{"$nulls":5},"bicellular tight junction",{"$nulls":3},1,1,1,12,12,12,"11.843","0.0026692","2.9217",5304100,2,"0.263206",1,"-5.34515","-0.659694","tr|A0A075B6G8|A0A075B6G8_HUMAN;tr|E2QRK7|E2QRK7_HUMAN;sp|Q5JTD0|TJAP1_HUMAN","tr|A0A075B6G8|A0A075B6G8_HUMAN;tr|E2QRK7|E2QRK7_HUMAN;sp|Q5JTD0|TJAP1_HUMAN",2826,"A0A075B6G8","A0A075B6G8_HUMAN",null,null,"TJAP1"]
[1,"15.9911","16.8096","17.0577","16.4674","16.3781",{"$nulls":3},"cell cycle;innate immune response;interferon-gamma-mediated signaling pathway;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein deubiquitination;negative regulation of viral release from host cell;negative regulation of viral transcription;positive regulation of autophagy;positive regulation of cell cycle;positive regulation of DNA binding transcription factor activity;positive regulation of viral entry into host cell;protein autoubiquitination;protein destabilization;protein monoubiquitination;protein polyubiquitination;protein trimerization;protein ubiquitination;regulation of type I interferon production;response to interferon-gamma","DNA binding;identical protein binding;RNA binding;ubiquitin-protein transferase activity;zinc ion binding","autophagosome;cytoplasm;cytoplasmic vesicle;cytosol;intracellular ribonucleoprotein complex;nucleoplasm;nucleus;P-body","Systemic lupus erythematosus",null,null,3,3,3,"8.6","8.6","8.6","54.169",0,"8.9797",25544000,3,"0.449044",1,"-5.36748","-1.04358","sp|P19474|RO52_HUMAN;tr|H0YDP8|H0YDP8_HUMAN","sp|P19474|RO52_HUMAN",1195,"P19474","RO52_HUMAN","E3 ubiquitin-protein ligase TRIM21",null,"TRIM21"]
["17.7149","16.9268",1,"18.2597","16.3013","17.1969",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitin-specific protease activity","cytosol;mitochondrion;nucleoplasm",{"$nulls":3},5,5,5,"6.7","6.7","6.7","119.03",0,"24.928",68853000,13,"0.417935",1,"-5.37205","-0.981307","sp|Q86UV5|UBP48_HUMAN;tr|A0A0A0MRS6|A0A0A0MRS6_HUMAN;tr|E9PJH5|E9PJH5_HUMAN","sp|Q86UV5|UBP48_HUMAN;tr|A0A0A0MRS6|A0A0A0MRS6_HUMAN",3223,"Q86UV5","UBP48_HUMAN","Ubiquitin carboxyl-terminal hydrolase 48",null,"USP48"]
["19.6048",1,1,"19.072","17.6639",1,{"$nulls":9},1,1,1,"17.3","17.3","17.3","17.52","0.0013566","3.157",12293000,3,"0.250979",1,"-5.37706","-0.633071","tr|C9J016|C9J016_HUMAN;sp|Q9H977|WDR54_HUMAN","tr|C9J016|C9J016_HUMAN;sp|Q9H977|WDR54_HUMAN",4535,"C9J016","C9J016_HUMAN",null,null,"WDR54"]
["17.1837","15.3625",1,"18.1962","14.7989","16.7052",{"$nulls":3},"microtubule cytoskeleton organization","structural molecule activity","cytosol;microtubule cytoskeleton;spindle",{"$nulls":3},6,6,6,"11.1","11.1","11.1","92.819",0,"11.684",71172000,18,"0.443843",1,"-5.38475","-1.03321","sp|Q3KQU3|MA7D1_HUMAN;tr|E9PLH3|E9PLH3_HUMAN;tr|C9JIR3|C9JIR3_HUMAN;tr|H0YF21|H0YF21_HUMAN","sp|Q3KQU3|MA7D1_HUMAN",2738,"Q3KQU3","MA7D1_HUMAN","MAP7 domain-containing protein 1",null,"MAP7D1"]
[1,1,"16.6092","16.7898",1,"16.9741",{"$nulls":3},"RNA processing","RNA binding;RNA methyltransferase activity",{"$nulls":4},7,7,7,"13.1","13.1","13.1","68.725",0,"11.586",74232000,10,"0.293834",1,"-5.38489","-0.725432","sp|Q8IZ69|TRM2A_HUMAN;tr|F2Z2W7|F2Z2W7_HUMAN;tr|C9K041|C9K041_HUMAN","sp|Q8IZ69|TRM2A_HUMAN;tr|F2Z2W7|F2Z2W7_HUMAN",3350,"Q8IZ69","TRM2A_HUMAN","tRNA (uracil-5-)-methyltransferase homolog A",null,"TRMT2A"]
["17.4789",1,"15.3941","16.6509","16.9855","16.4347",{"$nulls":3},"chromatin remodeling;DNA methylation;DNA repair;histone H2A acetylation;histone H4 acetylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of transcription factor import into nucleus;regulation of growth;response to ethanol;transcription, DNA-templated","RNA polymerase II repressing transcription factor binding;transcription corepressor activity","cytoplasm;cytosol;NuA4 histone acetyltransferase complex;nucleoplasm;nucleus;replication fork",{"$nulls":3},7,7,7,"27.6","27.6","27.6","52.992",0,"20.744",98348000,16,"0.448117",1,"-5.39937","-1.04174","sp|Q9NPF5|DMAP1_HUMAN;tr|Q5TG40|Q5TG40_HUMAN;tr|Q5TG38|Q5TG38_HUMAN;tr|Q5TG39|Q5TG39_HUMAN;tr|Q5TG37|Q5TG37_HUMAN;tr|Q5TG36|Q5TG36_HUMAN","sp|Q9NPF5|DMAP1_HUMAN;tr|Q5TG40|Q5TG40_HUMAN",4637,"Q9NPF5","DMAP1_HUMAN","DNA methyltransferase 1-associated protein 1","NMAP1;NMT1-associated protein 1","DMAP1"]
["17.5317","14.6622",1,"17.3535","15.6208","16.4278",{"$nulls":4},"ATP binding","cytoplasm",{"$nulls":3},5,5,5,"9.8","9.8","9.8","80.709",0,"9.5549",44308000,5,"0.45442",1,"-5.40276","-1.05429","sp|Q9BVQ7|SPA5L_HUMAN;tr|H0YCA5|H0YCA5_HUMAN","sp|Q9BVQ7|SPA5L_HUMAN",4261,"Q9BVQ7","SPA5L_HUMAN","Spermatogenesis-associated protein 5-like protein 1",null,"SPATA5L1"]
[1,1,"15.5974","16.7458",1,"16.0791",{"$nulls":4},"RNA binding","cytosol;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},10,1,1,"10.5","1.4","1.4","126.76","0.0011858","3.3879",75957000,4,"0.312146",1,"-5.40915","-0.764153","tr|Q5T1Z4|Q5T1Z4_HUMAN;tr|Q5T1Z8|Q5T1Z8_HUMAN;tr|H0YDK8|H0YDK8_HUMAN;tr|H0YC97|H0YC97_HUMAN","tr|Q5T1Z4|Q5T1Z4_HUMAN;tr|Q5T1Z8|Q5T1Z8_HUMAN;tr|H0YDK8|H0YDK8_HUMAN",5611,"Q5T1Z4","Q5T1Z4_HUMAN"]
["17.5324",1,1,"18.9286","15.833",1,{"$nulls":3},"mRNA processing;RNA phosphodiester bond hydrolysis, endonucleolytic;tRNA splicing, via endonucleolytic cleavage and ligation;tRNA-type intron splice site recognition and cleavage",null,"nucleolus;nucleoplasm;tRNA-intron endonuclease complex",{"$nulls":3},4,4,4,"11.2","11.2","11.2","58.819","0.00042141","4.575",34918000,3,"0.278529",1,"-5.40972","-0.692745","sp|Q7Z6J9|SEN54_HUMAN;tr|J3KRC5|J3KRC5_HUMAN;tr|J3QLM6|J3QLM6_HUMAN;tr|J9JIH8|J9JIH8_HUMAN","sp|Q7Z6J9|SEN54_HUMAN",3184,"Q7Z6J9","SEN54_HUMAN","tRNA-splicing endonuclease subunit Sen54",null,"TSEN54"]
["18.6662",1,"20.2255","17.6222","18.4718","20.0526",{"$nulls":9},4,4,4,33,33,33,"11.456",0,"8.1046",204150000,7,"0.36461",1,"-5.41829","-0.873064","sp|Q8N0T1|CH059_HUMAN;tr|A0A087WWE7|A0A087WWE7_HUMAN","sp|Q8N0T1|CH059_HUMAN",3362,"Q8N0T1","CH059_HUMAN","Uncharacterized protein C8orf59",null,"C8orf59"]
["21.0733","21.0334",1,"19.7743","20.8145","18.7798",{"$nulls":4},"calcium ion binding",{"$nulls":4},3,3,3,"28.1","28.1","28.1","14.45",0,"8.2025",82247000,3,"0.333021",1,"-5.42065","-0.807822","tr|A0A024QZ42|A0A024QZ42_HUMAN;sp|O75340|PDCD6_HUMAN;tr|H0Y9X3|H0Y9X3_HUMAN;tr|A0A087WZ38|A0A087WZ38_HUMAN","tr|A0A024QZ42|A0A024QZ42_HUMAN;sp|O75340|PDCD6_HUMAN",568,"A0A024QZ42","A0A024QZ42_HUMAN",null,null,"PDCD6"]
["20.0487","17.892",1,"19.9984","17.5319","17.6741",{"$nulls":9},3,3,3,"29.1","29.1","29.1","12.405",0,"7.24",38643000,3,"0.374034",1,"-5.42124","-0.892352","tr|E9PN51|E9PN51_HUMAN;tr|F8W9K7|F8W9K7_HUMAN;tr|E9PPW7|E9PPW7_HUMAN;sp|O00217|NDUS8_HUMAN;tr|E9PKH6|E9PKH6_HUMAN","tr|E9PN51|E9PN51_HUMAN;tr|F8W9K7|F8W9K7_HUMAN;tr|E9PPW7|E9PPW7_HUMAN;sp|O00217|NDUS8_HUMAN;tr|E9PKH6|E9PKH6_HUMAN",213,"E9PN51","E9PN51_HUMAN",null,null,"NDUFS8"]
[1,"16.073","17.4951","17.7735","15.7715","17.2966",{"$nulls":3},"dolichol-linked oligosaccharide biosynthetic process;protein glycosylation in endoplasmic reticulum;response to calcium ion","alpha-1,3-mannosyltransferase activity;calcium-dependent protein binding;GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity;GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity;protein heterodimerization activity;protein N-terminus binding","cytoplasm;endoplasmic reticulum membrane;integral component of membrane;membrane;nucleus;perinuclear region of cytoplasm","Metabolic pathways;N-Glycan biosynthesis",null,null,3,3,3,"13.2","13.2","13.2","47.091",0,"22.207",53567000,11,"0.437846",1,"-5.42452","-1.02123","sp|Q9H553|ALG2_HUMAN;tr|A0A0A0MTE0|A0A0A0MTE0_HUMAN","sp|Q9H553|ALG2_HUMAN",4477,"Q9H553","ALG2_HUMAN","Alpha-1,3/1,6-mannosyltransferase ALG2",null,"ALG2"]
[1,1,"14.6754",1,"14.3693","17.5806",{"$nulls":3},"endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);regulation of transcription from RNA polymerase II promoter;small-subunit processome assembly;spinal cord motor neuron differentiation;transcription from RNA polymerase II promoter","DNA binding;RNA binding;transcription coactivator activity","nucleolus;nucleus;transcription factor complex",{"$nulls":3},11,11,11,"55.9","55.9","55.9","31.079",0,"32.425",392630000,37,"0.326899",1,"-5.42485","-0.795065","sp|Q9ULW3|ABT1_HUMAN","sp|Q9ULW3|ABT1_HUMAN",5136,"Q9ULW3","ABT1_HUMAN","Activator of basal transcription 1","ABT1","ABT1"]
["18.962",1,1,"17.9405",1,"18.2999",{"$nulls":3},"cardiolipin acyl-chain remodeling;CDP-diacylglycerol biosynthetic process;multicellular organism development;phosphatidic acid biosynthetic process","1-acylglycerol-3-phosphate O-acyltransferase activity;O-acyltransferase activity","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane","Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways",null,null,2,2,2,"7.5","7.5","7.5","48.92","0.004848","2.5357",29398000,4,"0.261488",1,"-5.42614","-0.655967","sp|Q6UWP7|LCLT1_HUMAN;tr|C9K0C3|C9K0C3_HUMAN","sp|Q6UWP7|LCLT1_HUMAN;tr|C9K0C3|C9K0C3_HUMAN",3058,"Q6UWP7","LCLT1_HUMAN","Lysocardiolipin acyltransferase 1",null,"LCLAT1"]
[1,"15.8366","15.8085","17.8266","15.6246","15.4783",{"$nulls":3},"negative regulation of transmembrane transport;negative regulation of transporter activity;protein dephosphorylation","protein phosphatase 2A binding","actin cytoskeleton;cytoplasm",{"$nulls":3},4,4,4,"9.2","9.2","9.2","70.157",0,"9.8003",24063000,4,"0.470313",1,"-5.42813","-1.08586","sp|Q9P2B4|CT2NL_HUMAN;tr|B1AMN7|B1AMN7_HUMAN","sp|Q9P2B4|CT2NL_HUMAN",4929,"Q9P2B4","CT2NL_HUMAN","CTTNBP2 N-terminal-like protein",null,"CTTNBP2NL"]
["15.4015","13.8161",1,"15.9171","14.6375","15.9526",{"$nulls":4},"DNA binding","nucleus",{"$nulls":3},10,10,10,15,15,15,"111.83",0,"35.992",188640000,27,"0.520869",1,"-5.42987","-1.18562","tr|A0A0A0MSU2|A0A0A0MSU2_HUMAN;sp|Q6PJG2|EMSA1_HUMAN;tr|H7C1L3|H7C1L3_HUMAN;tr|C9JYU7|C9JYU7_HUMAN","tr|A0A0A0MSU2|A0A0A0MSU2_HUMAN;sp|Q6PJG2|EMSA1_HUMAN",3035,"A0A0A0MSU2","A0A0A0MSU2_HUMAN",null,null,"ELMSAN1"]
[1,"16.6049",1,"17.5654","16.3512",1,{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;skeletal muscle cell differentiation;transcription, DNA-templated","DNA binding;histone deacetylase activity;metal ion binding;transcription corepressor activity","histone deacetylase complex;nucleoplasm","Epstein-Barr virus infection",null,null,1,1,1,5,5,5,"23.306","0.00041554","4.2406",37310000,8,"0.295986",1,"-5.43725","-0.730005","sp|O75446|SAP30_HUMAN","sp|O75446|SAP30_HUMAN",591,"O75446","SAP30_HUMAN","Histone deacetylase complex subunit SAP30",null,"SAP30"]
[1,1,"16.3287","16.8518",1,"16.7947",{"$nulls":9},3,1,1,"17.9","5.5","5.5","29.956","0.0011933","3.4839",11664000,5,"0.301026",1,"-5.43928","-0.740688","tr|H0Y6A0|H0Y6A0_HUMAN","tr|H0Y6A0|H0Y6A0_HUMAN",5564,"H0Y6A0","H0Y6A0_HUMAN",null,null,"ARFGAP3"]
["15.9964",1,1,"17.1093",1,"16.227",{"$nulls":9},2,2,2,"3.3","3.3","3.3","82.672","0.0010062","3.6446",13447000,3,"0.306819",1,"-5.44665","-0.752932","tr|H0Y6M8|H0Y6M8_HUMAN;sp|Q9NZJ4|SACS_HUMAN;tr|B2REB0|B2REB0_HUMAN","tr|H0Y6M8|H0Y6M8_HUMAN;sp|Q9NZJ4|SACS_HUMAN;tr|B2REB0|B2REB0_HUMAN",4875,"H0Y6M8","H0Y6M8_HUMAN",null,null,"SACS"]
[1,1,"16.42","17.0864",1,"16.6773",{"$nulls":3},"positive regulation of ERK1 and ERK2 cascade;regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity","cytoplasm;cytosol",{"$nulls":3},3,3,3,"9.9","9.9","9.9","53.483",0,"7.2796",18601000,5,"0.299865",1,"-5.44788","-0.73823","sp|P85298|RHG08_HUMAN;tr|B7ZMA4|B7ZMA4_HUMAN;tr|H0Y9T8|H0Y9T8_HUMAN;tr|B1AHC3|B1AHC3_HUMAN;tr|B1AHC4|B1AHC4_HUMAN;tr|F8W6F4|F8W6F4_HUMAN;tr|B1AHC2|B1AHC2_HUMAN;tr|B1AHF8|B1AHF8_HUMAN;tr|F8WCV8|F8WCV8_HUMAN","sp|P85298|RHG08_HUMAN;tr|B7ZMA4|B7ZMA4_HUMAN;tr|H0Y9T8|H0Y9T8_HUMAN;tr|B1AHC3|B1AHC3_HUMAN;tr|B1AHC4|B1AHC4_HUMAN",2103,"P85298","RHG08_HUMAN","Rho GTPase-activating protein 8",null,"ARHGAP8"]
[1,"15.8414","16.3857","17.455","15.6327","16.4854",{"$nulls":3},"cardiac muscle cell proliferation;coronary artery morphogenesis;covalent chromatin modification;embryonic organ development;heart morphogenesis;homeostatic process;negative regulation of cell migration;negative regulation of cell proliferation;nucleosome disassembly;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;metal ion binding","nucleoplasm;plasma membrane","Hepatocellular carcinoma",null,null,25,25,25,"19.7","19.7","19.7","197.39",0,"77.19",722320000,64,"0.464925",1,"-5.44866","-1.07517","sp|Q68CP9|ARID2_HUMAN;tr|F8WCU9|F8WCU9_HUMAN;tr|F8W108|F8W108_HUMAN;tr|F8VWP4|F8VWP4_HUMAN;tr|A0A087WY37|A0A087WY37_HUMAN","sp|Q68CP9|ARID2_HUMAN;tr|F8WCU9|F8WCU9_HUMAN;tr|F8W108|F8W108_HUMAN",2928,"Q68CP9","ARID2_HUMAN","AT-rich interactive domain-containing protein 2 {ECO:0000305}","RID domain-containing protein 2 {ECO:0000305}","ARID2"]
[1,"18.6976","19.6167","18.2814","18.03","19.3728",{"$nulls":5},"endoplasmic reticulum;extracellular region;membrane;nucleus",{"$nulls":3},3,3,3,"17.9","17.9","17.9","26.56",0,"12.018",37722000,2,"0.377107",1,"-5.45665","-0.898626","sp|Q9H6E4|CC134_HUMAN;tr|B0QY51|B0QY51_HUMAN","sp|Q9H6E4|CC134_HUMAN",4485,"Q9H6E4","CC134_HUMAN","Coiled-coil domain-containing protein 134",null,"CCDC134"]
["18.5771",1,"19.0823","19.097","16.5512","19.418",{"$nulls":3},"tRNA modification;tRNA thio-modification;tRNA wobble uridine modification","transferase activity;tRNA binding","cytosol;mitochondrion","Sulfur relay system",null,null,6,6,6,"25.6","25.6","25.6","36.45",0,"12.903",108710000,9,"0.382388",1,"-5.4689","-0.909391","sp|Q7Z7A3|CTU1_HUMAN","sp|Q7Z7A3|CTU1_HUMAN",3191,"Q7Z7A3","CTU1_HUMAN","Cytoplasmic tRNA 2-thiolation protein 1 {ECO:0000255|HAMAP-Rule:MF_03053}",null,"CTU1"]
[1,"22.9367","23.7655","17.3417","22.9695","23.8115",{"$nulls":3},"BMP signaling pathway;SMAD protein signal transduction;transmembrane transport;transport","acetyl-CoA transmembrane transporter activity;solute:proton symporter activity","endoplasmic reticulum membrane;Golgi membrane;integral component of plasma membrane;membrane","Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways",null,null,3,3,3,"7.1","7.1","7.1","60.908","0.00042132","4.5682",1816900000,6,"0.285869",1,"-5.47349","-0.70846","sp|O00400|ACATN_HUMAN;tr|H7C562|H7C562_HUMAN","sp|O00400|ACATN_HUMAN;tr|H7C562|H7C562_HUMAN",229,"O00400","ACATN_HUMAN","Acetyl-coenzyme A transporter 1","cetyl-CoA transporter 1;T-1","SLC33A1"]
["17.2945","16.5832",1,"17.855","15.9198","17.5285",{"$nulls":9},3,3,3,"24.2","24.2","24.2","17.799",0,"6.7287",20425000,3,"0.438886",1,"-5.47517","-1.02331","tr|M0QYT5|M0QYT5_HUMAN;sp|Q9NZ43|USE1_HUMAN;tr|G8JLK1|G8JLK1_HUMAN;tr|M0QZE0|M0QZE0_HUMAN","tr|M0QYT5|M0QYT5_HUMAN;sp|Q9NZ43|USE1_HUMAN;tr|G8JLK1|G8JLK1_HUMAN",4866,"M0QYT5","M0QYT5_HUMAN",null,null,"USE1"]
["18.1095","16.7412",1,"17.8158","16.4292","18.0445",{"$nulls":3},"mRNA cleavage;rRNA processing;tRNA processing","ribonuclease activity;RNA binding","nucleolar ribonuclease P complex;ribonuclease MRP complex",{"$nulls":3},4,4,4,"24.9","24.9","24.9","20.903",0,"21.002",56498000,11,"0.424268",1,"-5.47959","-0.994032","tr|K7ERD7|K7ERD7_HUMAN;sp|O95707|RPP29_HUMAN;tr|K7ESH8|K7ESH8_HUMAN;tr|K7EQV2|K7EQV2_HUMAN;tr|K7EK50|K7EK50_HUMAN;tr|A0A0A0MQS4|A0A0A0MQS4_HUMAN","tr|K7ERD7|K7ERD7_HUMAN;sp|O95707|RPP29_HUMAN;tr|K7ESH8|K7ESH8_HUMAN;tr|K7EQV2|K7EQV2_HUMAN",779,"K7ERD7","K7ERD7_HUMAN",null,null,"POP4"]
["16.7228",1,"15.1593","16.5246","14.7578","18.069",{"$nulls":4},"GTP binding",{"$nulls":4},11,11,11,"29.1","29.1","29.1","56.897",0,"34.853",280560000,34,"0.466466",1,"-5.48975","-1.07823","tr|H0Y2S1|H0Y2S1_HUMAN;sp|O43824|GTPB6_HUMAN","tr|H0Y2S1|H0Y2S1_HUMAN;sp|O43824|GTPB6_HUMAN",465,"H0Y2S1","H0Y2S1_HUMAN",null,null,"GTPBP6"]
[1,"17.5693",1,"17.8066","17.2566",1,{"$nulls":3},"cholesterol biosynthetic process;estrogen biosynthetic process","3-keto sterol reductase activity;estradiol 17-beta-dehydrogenase activity","endoplasmic reticulum membrane;integral component of membrane;plasma membrane","Metabolic pathways;Ovarian steroidogenesis;Steroid biosynthesis;Steroid hormone biosynthesis",null,null,3,3,3,10,10,10,"38.206","0.00041408","4.1814",25741000,1,"0.284038",1,"-5.49798","-0.704547","sp|P56937|DHB7_HUMAN;tr|V9GYN3|V9GYN3_HUMAN","sp|P56937|DHB7_HUMAN",1871,"P56937","DHB7_HUMAN","3-keto-steroid reductase",null,"HSD17B7"]
[1,1,"16.5387","17.0617",1,"16.9946",{"$nulls":3},"embryonic limb morphogenesis;positive regulation of transcription from RNA polymerase II promoter;proximal/distal pattern formation","chromatin binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","nucleus;transcription factor complex",{"$nulls":3},2,2,2,"9.5","9.5","9.5","45.881","0.00021659","5.1834",12191000,3,"0.300655",1,"-5.50585","-0.739904","sp|P40425|PBX2_HUMAN","sp|P40425|PBX2_HUMAN",1518,"P40425","PBX2_HUMAN","Pre-B-cell leukemia transcription factor 2",null,"PBX2"]
["17.3247","18.1711",1,"18.138","17.2192","17.6678",{"$nulls":3},"Fc-gamma receptor signaling pathway involved in phagocytosis","actin binding","cytoskeleton;cytosol","Endocytosis;Yersinia infection",null,null,3,3,3,"9.3","9.3","9.3","46.288","0.00041615","4.2774",55077000,4,"0.419716",1,"-5.50973","-0.984888","sp|Q8TF74|WIPF2_HUMAN;tr|J3QKM5|J3QKM5_HUMAN","sp|Q8TF74|WIPF2_HUMAN",3589,"Q8TF74","WIPF2_HUMAN","WAS/WASL-interacting protein family member 2",null,"WIPF2"]
["16.1825","15.9756",1,"17.9243","15.4736","16.3284",{"$nulls":9},3,3,3,"7.7","7.7","7.7","64.317",0,"5.65",31298000,9,"0.471208",1,"-5.52275","-1.08764","tr|A0A087WXM0|A0A087WXM0_HUMAN;sp|Q01167|FOXK2_HUMAN;tr|E9PPI7|E9PPI7_HUMAN","tr|A0A087WXM0|A0A087WXM0_HUMAN;sp|Q01167|FOXK2_HUMAN",2132,"A0A087WXM0"]
["20.1833",1,"20.3846","19.5127","18.3323","20.3285",{"$nulls":9},1,1,1,"37.9","37.9","37.9","7.4492",0,"36.547",49473000,9,"0.357084",1,"-5.53523","-0.857604","tr|J3QLQ3|J3QLQ3_HUMAN;sp|Q8WVD3|RN138_HUMAN","tr|J3QLQ3|J3QLQ3_HUMAN;sp|Q8WVD3|RN138_HUMAN",3617,"J3QLQ3","J3QLQ3_HUMAN",null,null,"RNF138"]
["16.795","16.441",1,"17.6852","16.0816","17.093",{"$nulls":3},"DNA replication;histone H3 acetylation;histone H4-K12 acetylation;histone H4-K5 acetylation;histone H4-K8 acetylation;positive regulation of histone H4 acetylation;positive regulation of protein localization to nucleus;positive regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;response to actinomycin D;response to anisomycin;response to dithiothreitol;response to hydroxyurea;response to sorbitol;stress-activated protein kinase signaling cascade;transcription, DNA-templated","DNA binding transcription factor activity;DNA replication origin binding;histone acetyltransferase activity;transcription regulatory region DNA binding;zinc ion binding","cytosol;histone acetyltransferase complex;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"13.1","13.1","13.1","70.642",0,"34.602",156100000,25,"0.457246",1,"-5.54124","-1.05991","sp|O95251|KAT7_HUMAN;tr|E7EUP3|E7EUP3_HUMAN","sp|O95251|KAT7_HUMAN;tr|E7EUP3|E7EUP3_HUMAN",732,"O95251","KAT7_HUMAN","Histone acetyltransferase KAT7",null,"KAT7"]
["18.178","17.1337",1,"19.0354","17.2773","16.6241",{"$nulls":3},"negative regulation of Schwann cell proliferation;positive regulation of myelination;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;protein autoubiquitination;transcription, DNA-templated","metal ion binding;transcription regulatory region DNA binding;ubiquitin-protein transferase activity","cytoplasm;nucleus",{"$nulls":3},10,10,10,"17.1","17.1","17.1","89.926",0,"29.41",234780000,40,"0.421484",1,"-5.54174","-0.98844","sp|Q8N5U6|RNF10_HUMAN;tr|H0YF69|H0YF69_HUMAN;tr|H0YG28|H0YG28_HUMAN;tr|H0YFN9|H0YFN9_HUMAN;tr|H0YFQ9|H0YFQ9_HUMAN;tr|H0YGX5|H0YGX5_HUMAN;tr|F5H3A4|F5H3A4_HUMAN;tr|F5H510|F5H510_HUMAN;tr|F5H5P6|F5H5P6_HUMAN","sp|Q8N5U6|RNF10_HUMAN",3421,"Q8N5U6","RNF10_HUMAN","RING finger protein 10",null,"RNF10"]
[1,1,"18.4156","18.0278",1,"18.0415",{"$nulls":3},"apoptotic process;histone H2A monoubiquitination;multicellular organism development;negative regulation of G0 to G1 transition;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of transcription from RNA polymerase II promoter;positive regulation of apoptotic process;positive regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;metal ion binding;transcription corepressor activity","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"7.5","7.5","7.5","24.821",0,"18.035",31581000,12,"0.274277",1,"-5.55124","-0.683607","sp|Q8N488|RYBP_HUMAN","sp|Q8N488|RYBP_HUMAN",3396,"Q8N488","RYBP_HUMAN","RING1 and YY1-binding protein",null,"RYBP"]
[1,"18.0005","17.451","17.6181","17.8204","17.6778",{"$nulls":3},"immune system process;mRNA transport;protein import into nucleus","DNA binding;transferase activity, transferring acyl groups","cytosol;nuclear membrane;nuclear pore;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"1.7","1.7","1.7","218.4","0.00041152","4.1074",163980000,3,"0.425199",1,"-5.55495","-0.9959","sp|O60318|GANP_HUMAN","sp|O60318|GANP_HUMAN",486,"O60318","GANP_HUMAN","Germinal-center associated nuclear protein","ANP","MCM3AP"]
[1,"16.1485",1,"17.8769","15.986",1,{"$nulls":3},"aging;cellular response to calcium ion;cellular response to hormone stimulus;circadian rhythm;negative regulation of transcription from RNA polymerase II promoter;osteoblast development;positive regulation of cell differentiation;positive regulation of osteoblast differentiation;positive regulation of transcription from RNA polymerase II promoter;regulation of cell cycle;regulation of cell death;regulation of cell proliferation;regulation of transcription from RNA polymerase II promoter;response to cAMP;response to cytokine;response to drug;response to light stimulus;response to lipopolysaccharide;response to mechanical stimulus;response to peptide hormone;response to radiation","enzyme binding;ligand-dependent nuclear receptor binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcription coactivator activity;transcription factor binding;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","chromatin;nuclear chromatin;nucleus;protein-DNA complex;transcription factor AP-1 complex","IL-17 signaling pathway;MAPK signaling pathway;Osteoclast differentiation;Parathyroid hormone synthesis, secretion and action",null,null,2,2,2,"8.4","8.4","8.4","35.173",0,"5.7963",26045000,7,"0.309321",1,"-5.57149","-0.758207","sp|P17535|JUND_HUMAN;tr|U3KPR5|U3KPR5_HUMAN","sp|P17535|JUND_HUMAN;tr|U3KPR5|U3KPR5_HUMAN",1157,"P17535","JUND_HUMAN","Transcription factor jun-D",null,"JUND"]
["19.0347",1,"16.9633","18.9466","16.0505","18.7558",{"$nulls":3},"cellular hyperosmotic response;cellular response to dexamethasone stimulus;cellular response to epidermal growth factor stimulus;cellular response to insulin stimulus;cellular response to platelet-derived growth factor stimulus;lung alveolus development;lung epithelium development;lung vasculature development;negative regulation of cardiac muscle hypertrophy in response to stress;negative regulation of collagen biosynthetic process;negative regulation of epidermal growth factor-activated receptor activity;negative regulation of ERK1 and ERK2 cascade;negative regulation of interleukin-1 beta production;negative regulation of protein autophosphorylation;negative regulation of tumor necrosis factor biosynthetic process;regulation of keratinocyte differentiation;regulation of type B pancreatic cell proliferation;response to stress;skin morphogenesis","GTPase activator activity;protein kinase binding;SH3 domain binding;small GTPase binding","cytoplasm;cytosol;extrinsic component of cytoplasmic side of plasma membrane;nucleus",{"$nulls":3},3,3,3,"14.3","14.3","14.3","50.559",0,"8.6609",41038000,7,"0.410954",1,"-5.58496","-0.967253","sp|Q9UJM3|ERRFI_HUMAN","sp|Q9UJM3|ERRFI_HUMAN",5061,"Q9UJM3","ERRFI_HUMAN","ERBB receptor feedback inhibitor 1",null,"ERRFI1"]
[1,"17.4072","17.3269","17.4775","17.2055","17.8331",{"$nulls":9},53,1,0,"27.7","0.5",0,"286.97",0,"31.362",190940000,17,"0.439622",1,"-5.59401","-1.02478","tr|E9PEM5|E9PEM5_HUMAN;tr|H0Y9N9|H0Y9N9_HUMAN;tr|A0A0A6YYC1|A0A0A6YYC1_HUMAN","tr|E9PEM5|E9PEM5_HUMAN",5513,"E9PEM5","E9PEM5_HUMAN",null,null,"LRBA"]
[1,"17.2071",1,"17.7671","17.2571",1,{"$nulls":3},"apoptotic process;mitotic cytokinesis;negative regulation of microtubule depolymerization;positive regulation of transcription from RNA polymerase II promoter",null,"centrosome;cytoplasmic microtubule;cytosol;microtubule cytoskeleton;spindle pole",{"$nulls":3},5,5,5,"9.8","9.8","9.8","76.986",0,"30.367",184680000,23,"0.29444",1,"-5.60573","-0.726721","sp|Q8WWK9|CKAP2_HUMAN;tr|C9J7Y4|C9J7Y4_HUMAN","sp|Q8WWK9|CKAP2_HUMAN",3636,"Q8WWK9","CKAP2_HUMAN","Cytoskeleton-associated protein 2",null,"CKAP2"]
["15.3165","14.5644",1,"16.1482","15.7562","15.7942",{"$nulls":4},"ATP binding;helicase activity;metal ion binding;RNA binding","membrane;nucleus",{"$nulls":3},6,6,6,"5.6","5.6","5.6","218.97",0,"20.843",55809000,15,"0.530557",1,"-5.60588","-1.20464","sp|P42694|HELZ_HUMAN;tr|J3QS41|J3QS41_HUMAN;tr|J3QRR8|J3QRR8_HUMAN;tr|A0A075B6R3|A0A075B6R3_HUMAN","sp|P42694|HELZ_HUMAN;tr|J3QS41|J3QS41_HUMAN",1555,"P42694","HELZ_HUMAN","Probable helicase with zinc finger domain",null,"HELZ"]
[1,"21.3054",1,"19.7916","19.3393",1,{"$nulls":9},1,1,1,"5.6","5.6","5.6","16.226","0.0071612","2.3159",4554000000,39,"0.241142",1,"-5.6085","-0.611478","tr|V9GYU3|V9GYU3_HUMAN;tr|J3KNJ7|J3KNJ7_HUMAN;sp|Q8N3J2|METL4_HUMAN","tr|V9GYU3|V9GYU3_HUMAN;tr|J3KNJ7|J3KNJ7_HUMAN;sp|Q8N3J2|METL4_HUMAN",3392,"V9GYU3","V9GYU3_HUMAN",null,null,"METTL4"]
["15.1631","13.8637",1,"16.7499","13.9188","16.2246",{"$nulls":3},"anatomical structure morphogenesis;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;cellular response to tumor necrosis factor;cortical actin cytoskeleton organization;Fc-epsilon receptor signaling pathway;I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;interleukin-1-mediated signaling pathway;MyD88-independent toll-like receptor signaling pathway;negative regulation of apoptotic process;negative regulation of bicellular tight junction assembly;negative regulation of myosin-light-chain-phosphatase activity;nucleotide-binding oligomerization domain containing signaling pathway;peptidyl-serine phosphorylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;protein localization to plasma membrane;protein phosphorylation;regulation of establishment of endothelial barrier;regulation of phosphorylation;regulation of tumor necrosis factor-mediated signaling pathway;response to virus;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;TRIF-dependent toll-like receptor signaling pathway;tumor necrosis factor-mediated signaling pathway","ATP binding;identical protein binding;IkappaB kinase activity;protein heterodimerization activity;protein homodimerization activity;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;scaffold protein binding","CD40 receptor complex;cytoplasmic side of plasma membrane;cytosol;IkappaB kinase complex;membrane raft;nucleus","Acute myeloid leukemia;Adipocytokine signaling pathway;Antifolate resistance;Apoptosis;B cell receptor signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Chronic myeloid leukemia;C-type lectin receptor signaling pathway;Cytosolic DNA-sensing pathway;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fluid shear stress and atherosclerosis;FoxO signaling pathway;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;IL-17 signaling pathway;Influenza A;Insulin resistance;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;MAPK signaling pathway;Measles;MicroRNAs in cancer;mTOR signaling pathway;Neurotrophin signaling pathway;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Prostate cancer;Ras signaling pathway;RIG-I-like receptor signaling pathway;Shigellosis;Small cell lung cancer;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Type II diabetes mellitus;Yersinia infection",null,null,4,4,4,"6.5","6.5","6.5","86.563",0,"11.881",19291000,6,"0.539121",1,"-5.62216","-1.22143","sp|O14920|IKKB_HUMAN;tr|E5RGW5|E5RGW5_HUMAN;tr|G3V105|G3V105_HUMAN","sp|O14920|IKKB_HUMAN;tr|E5RGW5|E5RGW5_HUMAN;tr|G3V105|G3V105_HUMAN",308,"O14920","IKKB_HUMAN","Inhibitor of nuclear factor kappa-B kinase subunit beta",{"$f":"-kappa-B-kinase beta,kBKB,KK-B,KK-beta","v":{"$error":"#NAME?"}},"IKBKB"]
["20.3035",1,"18.897","20.2243","17.0737","19.7874",{"$nulls":3},"negative regulation of epidermal growth factor-activated receptor activity;signal transduction","cadherin binding;G-protein coupled receptor activity","cytoplasmic vesicle membrane;extracellular exosome;integral component of plasma membrane;intracellular membrane-bounded organelle;nucleolus;plasma membrane;vesicle",{"$nulls":3},2,2,2,"13.4","13.4","13.4","40.251","0.0043015","2.5999",30702000,6,"0.37516",1,"-5.6283","-0.894653","sp|Q8NFJ5|RAI3_HUMAN;tr|F5GWG3|F5GWG3_HUMAN","sp|Q8NFJ5|RAI3_HUMAN;tr|F5GWG3|F5GWG3_HUMAN",3508,"Q8NFJ5","RAI3_HUMAN","Retinoic acid-induced protein 3",null,"GPRC5A"]
[1,1,"15.985","17.4879",1,"16.3917",{"$nulls":3},"chromatin remodeling;DNA-templated transcription, initiation;histone H3 acetylation;regulation of DNA binding transcription factor activity;regulation of transcription from RNA polymerase II promoter","DNA binding;protein heterodimerization activity;transcription coactivator activity","extracellular exosome;histone deacetylase complex;nucleoplasm;nucleus;STAGA complex","Basal transcription factors",null,null,8,8,8,"17.2","17.2","17.2","67.814",0,"33.398",154840000,22,"0.315648",1,"-5.63155","-0.771512","sp|Q9Y6J9|TAF6L_HUMAN;tr|E9PP94|E9PP94_HUMAN","sp|Q9Y6J9|TAF6L_HUMAN",5412,"Q9Y6J9","TAF6L_HUMAN","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L",null,"TAF6L"]
[1,"18.3777","17.334","18.5969","18.0918","16.9187",{"$nulls":3},"histone H3-K4 methylation;histone H3-K4 trimethylation","chromatin binding","chromatin;histone methyltransferase complex;nucleolus;PTW/PP1 phosphatase complex;Set1C/COMPASS complex","mRNA surveillance pathway",null,null,6,6,6,"23.6","23.6","23.6","35.079",0,"15.285",92219000,18,"0.425768",1,"-5.63189","-0.997041","sp|Q6UXN9|WDR82_HUMAN;tr|C9JBU3|C9JBU3_HUMAN","sp|Q6UXN9|WDR82_HUMAN",3063,"Q6UXN9","WDR82_HUMAN","WD repeat-containing protein 82",null,"WDR82"]
[1,"10.4487","16.8953","14.3572","14.0509","16.8328",{"$nulls":3},"protein ubiquitination;regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding;transferase activity","membrane;nucleus",{"$nulls":3},35,35,35,"10.1","10.1","10.1","510.08",0,"97.87",497110000,81,"0.527478",1,"-5.63227","-1.1986","sp|O75592|MYCB2_HUMAN;tr|H7C3U4|H7C3U4_HUMAN;tr|A0A087WY34|A0A087WY34_HUMAN;tr|A0A0C4DGY7|A0A0C4DGY7_HUMAN","sp|O75592|MYCB2_HUMAN",611,"O75592","MYCB2_HUMAN","E3 ubiquitin-protein ligase MYCBP2",null,"MYCBP2"]
[1,"15.1859","15.6954","18.3048","14.4786","16.0522",{"$nulls":4},"nucleic acid binding",{"$nulls":4},3,3,3,"11.3","11.3","11.3","44.294","0.0013605","3.1887",12921000,5,"0.499476",1,"-5.65144","-1.14352","tr|A0A0D9SF44|A0A0D9SF44_HUMAN;sp|Q9Y3T6|R3HC1_HUMAN;tr|A0A0D9SG39|A0A0D9SG39_HUMAN;tr|E5RHX3|E5RHX3_HUMAN;tr|E5RIQ4|E5RIQ4_HUMAN;tr|H0YBU3|H0YBU3_HUMAN;tr|E5RIK1|E5RIK1_HUMAN","tr|A0A0D9SF44|A0A0D9SF44_HUMAN;sp|Q9Y3T6|R3HC1_HUMAN;tr|A0A0D9SG39|A0A0D9SG39_HUMAN;tr|E5RHX3|E5RHX3_HUMAN;tr|E5RIQ4|E5RIQ4_HUMAN",5305,"A0A0D9SF44","A0A0D9SF44_HUMAN",null,null,"R3HCC1"]
["19.0977",1,"21.4575","20.0081","17.174","21.3617",{"$nulls":4},"RNA binding","nucleus",{"$nulls":3},4,4,4,"30.2","30.2","30.2","20.599",0,"11.911",156440000,12,"0.358637",1,"-5.66286","-0.860799","sp|Q8N6N3|CA052_HUMAN","sp|Q8N6N3|CA052_HUMAN",3427,"Q8N6N3","CA052_HUMAN","UPF0690 protein C1orf52",null,"C1orf52"]
[1,"17.9753",1,"17.4786","18.5437",1,{"$nulls":3},"microtubule-based movement","ATP binding;microtubule binding;microtubule motor activity",{"$nulls":4},8,1,1,"32.7","6.3","6.3","32.692",0,"23.038",83958000,2,"0.28604",1,"-5.68236","-0.708825","tr|D6R9M0|D6R9M0_HUMAN","tr|D6R9M0|D6R9M0_HUMAN",5493,"D6R9M0","D6R9M0_HUMAN",null,null,"KIF2A"]
["20.0863",1,1,"18.3089",1,"19.8316",{"$nulls":3},"androgen receptor signaling pathway;cell aging;cellular response to oxidative stress;cellular response to testosterone stimulus;cytoplasmic translation;positive regulation of androgen receptor activity",null,"cytoplasm;polysome",{"$nulls":3},2,2,2,"14.4","14.4","14.4","27.939",0,"6.4765",33794000,1,"0.257842",1,"-5.68475","-0.648043","sp|Q9H446|RWDD1_HUMAN;tr|E5RJE3|E5RJE3_HUMAN;tr|E5RGS5|E5RGS5_HUMAN;tr|E5RGQ3|E5RGQ3_HUMAN","sp|Q9H446|RWDD1_HUMAN;tr|E5RJE3|E5RJE3_HUMAN;tr|E5RGS5|E5RGS5_HUMAN;tr|E5RGQ3|E5RGQ3_HUMAN",4457,"Q9H446","RWDD1_HUMAN","RWD domain-containing protein 1",null,"RWDD1"]
[1,1,"17.196","17.991",1,"17.2794",{"$nulls":4},"methyltransferase activity","mitochondrion",{"$nulls":3},2,2,2,"11.3","11.3","11.3","25.414","0.0091258","2.2341",20568000,1,"0.298415",1,"-5.69146","-0.735158","tr|C9J236|C9J236_HUMAN;tr|C9JS27|C9JS27_HUMAN;sp|Q7L592|NDUF7_HUMAN;tr|C9JEL7|C9JEL7_HUMAN;tr|C9JP36|C9JP36_HUMAN","tr|C9J236|C9J236_HUMAN;tr|C9JS27|C9JS27_HUMAN;sp|Q7L592|NDUF7_HUMAN;tr|C9JEL7|C9JEL7_HUMAN;tr|C9JP36|C9JP36_HUMAN",3125,"C9J236","C9J236_HUMAN","Protein arginine methyltransferase NDUFAF7 {ECO:0000256|RuleBase:RU364114}",null,"NDUFAF7"]
["17.714","14.1978",1,"18.5752","14.101","17.3317",{"$nulls":5},"integral component of membrane;nuclear membrane;nucleoplasm",{"$nulls":3},6,6,6,"7.7","7.7","7.7","125.09",0,"12.602",79967000,8,"0.469134",1,"-5.6987","-1.08353","tr|A0A075B7F8|A0A075B7F8_HUMAN;sp|A8CG34|P121C_HUMAN;tr|A0A087WY75|A0A087WY75_HUMAN;sp|Q96HA1|P121A_HUMAN;sp|A6NF01|P121B_HUMAN;tr|C9JFL1|C9JFL1_HUMAN;tr|C9JER0|C9JER0_HUMAN;sp|Q6PJE2|POZP3_HUMAN;tr|C9J370|C9J370_HUMAN;tr|A0A0J9YWR1|A0A0J9YWR1_HUMAN","tr|A0A075B7F8|A0A075B7F8_HUMAN;sp|A8CG34|P121C_HUMAN;tr|A0A087WY75|A0A087WY75_HUMAN;sp|Q96HA1|P121A_HUMAN",190,"A0A075B7F8","A0A075B7F8_HUMAN",null,null,"POM121C"]
["18.3798",1,"17.9824","19.1175","17.6172","17.7267",{"$nulls":3},"activation of MAPKK activity;amyloid precursor protein catabolic process;amyloid precursor protein metabolic process;amyloid-beta formation;astrocyte activation;astrocyte activation involved in immune response;autophagosome assembly;blood vessel development;brain morphogenesis;Cajal-Retzius cell differentiation;canonical Wnt signaling pathway;cell fate specification;cell-cell adhesion;cellular response to amyloid-beta;cellular response to DNA damage stimulus;cerebral cortex cell migration;choline transport;dorsal/ventral neural tube patterning;embryonic limb morphogenesis;endoplasmic reticulum calcium ion homeostasis;ephrin receptor signaling pathway;epithelial cell proliferation;heart looping;hematopoietic progenitor cell differentiation;intracellular signal transduction;learning or memory;L-glutamate transport;membrane protein ectodomain proteolysis;membrane protein intracellular domain proteolysis;memory;mitochondrial transport;modulation of age-related behavioral decline;myeloid dendritic cell differentiation;negative regulation of apoptotic process;negative regulation of apoptotic signaling pathway;negative regulation of axonogenesis;negative regulation of core promoter binding;negative regulation of epidermal growth factor-activated receptor activity;negative regulation of neuron apoptotic process;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of ubiquitin-protein transferase activity;neural retina development;neuron apoptotic process;neuron development;neuron migration;neuron projection maintenance;neutrophil degranulation;Notch receptor processing;Notch signaling pathway;positive regulation of amyloid fibril formation;positive regulation of apoptotic process;positive regulation of catalytic activity;positive regulation of coagulation;positive regulation of dendritic spine development;positive regulation of phosphorylation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein binding;positive regulation of protein import into nucleus, translocation;positive regulation of receptor recycling;positive regulation of transcription, DNA-templated;post-embryonic development;protein glycosylation;protein processing;protein transport;regulation of canonical Wnt signaling pathway;regulation of phosphorylation;regulation of resting membrane potential;regulation of synaptic plasticity;regulation of synaptic transmission, glutamatergic;response to oxidative stress;skeletal system morphogenesis;skin morphogenesis;smooth endoplasmic reticulum calcium ion homeostasis;somitogenesis;synapse organization;synaptic vesicle targeting;T cell activation involved in immune response;T cell receptor signaling pathway;thymus development","aspartic endopeptidase activity, intramembrane cleaving;aspartic-type endopeptidase activity;beta-catenin binding;cadherin binding;calcium channel activity;endopeptidase activity;PDZ domain binding","aggresome;axon;azurophil granule membrane;cell cortex;cell junction;cell surface;centrosome;ciliary rootlet;dendritic shaft;endoplasmic reticulum;endoplasmic reticulum membrane;gamma-secretase complex;Golgi apparatus;Golgi membrane;growth cone;integral component of membrane;integral component of plasma membrane;kinetochore;lysosomal membrane;membrane;membrane raft;mitochondrial inner membrane;mitochondrion;neuromuscular junction;neuronal cell body;nuclear membrane;nuclear outer membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;presynapse;protein complex;rough endoplasmic reticulum;smooth endoplasmic reticulum;Z disc","Alzheimer disease;Human papillomavirus infection;Neurotrophin signaling pathway;Notch signaling pathway;Wnt signaling pathway",null,null,2,2,2,"7.5","7.5","7.5","52.667","0.00041571","4.261",31336000,3,"0.423014",1,"-5.69972","-0.991513","sp|P49768|PSN1_HUMAN;tr|G3V2B1|G3V2B1_HUMAN;tr|G3V519|G3V519_HUMAN;tr|G3V4M0|G3V4M0_HUMAN;tr|H0YM52|H0YM52_HUMAN;tr|G3V4P4|G3V4P4_HUMAN;tr|G3V3Z0|G3V3Z0_HUMAN;tr|G3V499|G3V499_HUMAN;tr|G3V2G7|G3V2G7_HUMAN;tr|E7ES96|E7ES96_HUMAN","sp|P49768|PSN1_HUMAN;tr|G3V2B1|G3V2B1_HUMAN;tr|G3V519|G3V519_HUMAN;tr|G3V4M0|G3V4M0_HUMAN;tr|H0YM52|H0YM52_HUMAN;tr|G3V4P4|G3V4P4_HUMAN;tr|G3V3Z0|G3V3Z0_HUMAN;tr|G3V499|G3V499_HUMAN;tr|G3V2G7|G3V2G7_HUMAN;tr|E7ES96|E7ES96_HUMAN",1680,"P49768","PSN1_HUMAN","Presenilin-1","S-1","PSEN1"]
["19.8038",1,"19.8552","19.4308","18.6679","19.6624",{"$nulls":4},"metal ion binding;methyltransferase activity",{"$nulls":4},3,3,3,"8.6","8.6","8.6","47.34",0,"10.03",108600000,7,"0.381324",1,"-5.70071","-0.907224","sp|Q6GMV2|SMYD5_HUMAN;tr|E2QRN5|E2QRN5_HUMAN;tr|F8WEJ9|F8WEJ9_HUMAN;tr|C9IYN9|C9IYN9_HUMAN","sp|Q6GMV2|SMYD5_HUMAN",2953,"Q6GMV2","SMYD5_HUMAN","SET and MYND domain-containing protein 5",null,"SMYD5"]
[1,1,"18.3938","18.1936",1,"18.3128",{"$nulls":3},"response to ionizing radiation","beta-catenin binding",{"$nulls":4},2,2,2,"20.5","20.5","20.5","21.494",0,"8.8292",20232000,4,"0.281207",1,"-5.7042","-0.698488","sp|Q8WZA0|LZIC_HUMAN;tr|K7ES95|K7ES95_HUMAN","sp|Q8WZA0|LZIC_HUMAN;tr|K7ES95|K7ES95_HUMAN",3660,"Q8WZA0","LZIC_HUMAN","Protein LZIC",null,"LZIC"]
[1,1,"17.1728","17.3056",1,"18.0218",{"$nulls":3},"cellular response to drug;histone dephosphorylation;intrinsic apoptotic signaling pathway;negative regulation of peptidyl-serine phosphorylation;negative regulation of protein kinase activity;negative regulation of protein kinase activity by regulation of protein phosphorylation;negative regulation of transcription, DNA-templated;peptidyl-threonine dephosphorylation;positive regulation of cell-substrate adhesion;positive regulation of chemotaxis;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of epithelial cell migration;positive regulation of focal adhesion assembly;positive regulation of gene expression;positive regulation of growth;positive regulation of stress fiber assembly","calmodulin-dependent protein phosphatase activity;metal ion binding;protein serine/threonine phosphatase activity","cytosol;perinuclear region of cytoplasm;protein complex",{"$nulls":3},2,2,2,"7.9","7.9","7.9","49.83",0,"20.985",15275000,2,"0.299981",1,"-5.71822","-0.738476","sp|P49593|PPM1F_HUMAN;tr|B5MCT7|B5MCT7_HUMAN;tr|A8MX49|A8MX49_HUMAN","sp|P49593|PPM1F_HUMAN;tr|B5MCT7|B5MCT7_HUMAN;tr|A8MX49|A8MX49_HUMAN",1669,"P49593","PPM1F_HUMAN","Protein phosphatase 1F",null,"PPM1F"]
["16.0798","15.6896",1,"18.8678","15.4244","15.6364",{"$nulls":4},"cytoskeletal protein binding","cytoskeleton",{"$nulls":3},8,8,8,"26.9","26.9","26.9","58.506",0,"99.499",289480000,51,"0.489844",1,"-5.7197","-1.12451","tr|B5MC67|B5MC67_HUMAN;sp|Q7Z6J6|FRMD5_HUMAN;tr|H0YKW6|H0YKW6_HUMAN;tr|H0Y5N1|H0Y5N1_HUMAN;tr|H0YNI9|H0YNI9_HUMAN;tr|A0A087WVP2|A0A087WVP2_HUMAN;tr|F8WCI0|F8WCI0_HUMAN;tr|H7C282|H7C282_HUMAN;tr|F8WEJ8|F8WEJ8_HUMAN","tr|B5MC67|B5MC67_HUMAN;sp|Q7Z6J6|FRMD5_HUMAN;tr|H0YKW6|H0YKW6_HUMAN;tr|H0Y5N1|H0Y5N1_HUMAN;tr|H0YNI9|H0YNI9_HUMAN",3183,"B5MC67","B5MC67_HUMAN",null,null,"FRMD5"]
[1,1,"16.2651","18.1287",1,"16.3466",{"$nulls":9},4,4,4,"7.8","7.8","7.8","83.674","0.0011732","3.2552",23324000,5,"0.31511",1,"-5.73675","-0.770384","tr|F5H0F9|F5H0F9_HUMAN;sp|Q9UJX4|APC5_HUMAN;tr|F5GY68|F5GY68_HUMAN;tr|H0YFB5|H0YFB5_HUMAN;tr|F5H3S5|F5H3S5_HUMAN;tr|F5H0N1|F5H0N1_HUMAN","tr|F5H0F9|F5H0F9_HUMAN;sp|Q9UJX4|APC5_HUMAN;tr|F5GY68|F5GY68_HUMAN;tr|H0YFB5|H0YFB5_HUMAN",5069,"F5H0F9","F5H0F9_HUMAN",null,null,"ANAPC5"]
["19.5152",1,1,"19.4432",1,"18.3319",{"$nulls":4},"RNA polymerase II transcription cofactor activity","mediator complex;nuclear body;nucleus",{"$nulls":3},2,2,2,"20.5","20.5","20.5","26.287",0,"18.69",115910000,9,"0.26795",1,"-5.7533","-0.669963","tr|J3KR33|J3KR33_HUMAN;sp|A0JLT2|MED19_HUMAN","tr|J3KR33|J3KR33_HUMAN;sp|A0JLT2|MED19_HUMAN",165,"J3KR33","J3KR33_HUMAN","Mediator of RNA polymerase II transcription subunit 19 {ECO:0000256|RuleBase:RU364151}"]
[1,"16.627","17.723","18.5995","16.1087","17.9168",{"$nulls":3},"cell cycle;cell differentiation;negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;transcription corepressor activity;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytosol;nucleoplasm;nucleus",{"$nulls":3},8,8,8,"24.1","24.1","24.1","58.702",0,"38.383",115630000,18,"0.455392",1,"-5.75835","-1.05622","sp|P50548|ERF_HUMAN","sp|P50548|ERF_HUMAN",1711,"P50548","ERF_HUMAN","ETS domain-containing transcription factor ERF",null,"ERF"]
[1,"14.2594","15.7694","16.7638","14.5838","16.9687",{"$nulls":3},"histone H3-K36 demethylation;negative regulation of histone H3-K9 trimethylation","histone demethylase activity (H3-K9 specific);metal ion binding","cytosol;nuclear pericentric heterochromatin;nucleus",{"$nulls":3},8,8,8,"12.7","12.7","12.7","121.9",0,"45.973",200300000,30,"0.534453",1,"-5.76249","-1.21228","tr|A0A0C4DFL8|A0A0C4DFL8_HUMAN;sp|O94953|KDM4B_HUMAN;tr|F5GX28|F5GX28_HUMAN;tr|K7EQ54|K7EQ54_HUMAN","tr|A0A0C4DFL8|A0A0C4DFL8_HUMAN;sp|O94953|KDM4B_HUMAN;tr|F5GX28|F5GX28_HUMAN;tr|K7EQ54|K7EQ54_HUMAN",699,"A0A0C4DFL8","A0A0C4DFL8_HUMAN",null,null,"KDM4B"]
[1,"13.9682","14.9255","18.5523","13.64","15.0033",{"$nulls":3},"regulation of ARF protein signal transduction","ARF guanyl-nucleotide exchange factor activity",{"$nulls":4},6,6,5,"6.7","6.7","6.2","145.49",0,"11.107",98010000,12,"0.538901",1,"-5.76731","-1.221","tr|E5RIF2|E5RIF2_HUMAN;sp|Q9Y6D6|BIG1_HUMAN;tr|E5RHL7|E5RHL7_HUMAN","tr|E5RIF2|E5RIF2_HUMAN;sp|Q9Y6D6|BIG1_HUMAN;tr|E5RHL7|E5RHL7_HUMAN",5403,"E5RIF2","E5RIF2_HUMAN",null,null,"ARFGEF1"]
[1,"17.8606","17.4764","18.5311","17.4039","17.7699",{"$nulls":3},"brain development;eye development;heart development;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay","identical protein binding","cytosol;intracellular",{"$nulls":3},4,4,4,"12.5","12.5","12.5","57.65",0,"6.0987",31400000,6,"0.447193",1,"-5.78927","-1.03989","sp|Q9H0W8|SMG9_HUMAN;tr|M0QZC7|M0QZC7_HUMAN;tr|M0QZH1|M0QZH1_HUMAN;tr|M0QX70|M0QX70_HUMAN;tr|M0QYR7|M0QYR7_HUMAN;tr|M0R2N0|M0R2N0_HUMAN;tr|M0R0U0|M0R0U0_HUMAN","sp|Q9H0W8|SMG9_HUMAN;tr|M0QZC7|M0QZC7_HUMAN;tr|M0QZH1|M0QZH1_HUMAN;tr|M0QX70|M0QX70_HUMAN;tr|M0QYR7|M0QYR7_HUMAN;tr|M0R2N0|M0R2N0_HUMAN;tr|M0R0U0|M0R0U0_HUMAN",4403,"Q9H0W8","SMG9_HUMAN","Protein SMG9 {ECO:0000305}",null,"SMG9"]
[1,"17.7657","17.0471","17.8164","17.8994","17.4916",{"$nulls":3},"actin cytoskeleton organization;actin filament organization;calcium ion transport;cell-substrate adhesion;cellular response to interleukin-4;early endosome to recycling endosome transport;homeostasis of number of cells within a tissue;innate immune response;leukocyte chemotaxis;movement of cell or subcellular component;natural killer cell degranulation;negative regulation of actin nucleation;negative regulation of neuron apoptotic process;negative regulation of vesicle fusion;nerve growth factor signaling pathway;phagocytosis;phagolysosome assembly;positive chemotaxis;positive regulation of cell migration;positive regulation of T cell proliferation;regulation of actin cytoskeleton organization;regulation of cell shape;regulation of release of sequestered calcium ion into cytosol;T cell homeostasis;uropod organization","actin binding;actin filament binding;actin monomer binding;cytoskeletal protein binding;myosin heavy chain binding;phosphatidylinositol 3-kinase binding;protein C-terminus binding;protein homodimerization activity;RNA binding","actin filament;axon;cell-cell junction;cortical actin cytoskeleton;cytoplasm;cytosol;early endosome;extracellular exosome;immunological synapse;lamellipodium;membrane;phagocytic cup;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane;protein complex","Phagosome;Tuberculosis",null,null,1,1,1,"3.5","3.5","3.5","51.026","0.00041797","4.3644",37191000,3,"0.456886",1,"-5.7982","-1.0592","sp|P31146|COR1A_HUMAN","sp|P31146|COR1A_HUMAN",1398,"P31146","COR1A_HUMAN","Coronin-1A",null,"CORO1A"]
[1,"18.268","17.9235","18.6188","17.9525","18.0347",{"$nulls":4},"lipid transporter activity","integral component of membrane",{"$nulls":3},3,3,3,5,5,5,"55.835","0.0048399","2.5147",45547000,2,"0.436133",1,"-5.80485","-1.0178","tr|B5MDE0|B5MDE0_HUMAN;sp|Q96AA3|RFT1_HUMAN;tr|C9JP01|C9JP01_HUMAN","tr|B5MDE0|B5MDE0_HUMAN;sp|Q96AA3|RFT1_HUMAN",3785,"B5MDE0","B5MDE0_HUMAN"]
[1,"16.9184","18.3162","18.7643","16.6446","18.2428",{"$nulls":3},"intracellular signal transduction","metal ion binding","intracellular",{"$nulls":3},2,2,2,13,13,13,"35.487",0,"7.3641",47814000,6,"0.446512",1,"-5.80568","-1.03853","tr|J3KRN5|J3KRN5_HUMAN;sp|P17252|KPCA_HUMAN","tr|J3KRN5|J3KRN5_HUMAN;sp|P17252|KPCA_HUMAN",1151,"J3KRN5","J3KRN5_HUMAN",null,null,"PRKCA"]
[1,"16.1","16.0414","18.5336","15.8482","16.1841",{"$nulls":3},"cellular response to leukemia inhibitory factor;positive regulation of gene expression, epigenetic;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription initiation from RNA polymerase I promoter","DNA-directed 5'-3' RNA polymerase activity","DNA-directed RNA polymerase I complex;nucleoplasm","RNA polymerase",null,null,6,6,6,"19.2","19.2","19.2","37.432",0,"40.429",158540000,22,"0.497775",1,"-5.80815","-1.14017","sp|Q3B726|RPA43_HUMAN","sp|Q3B726|RPA43_HUMAN",2736,"Q3B726","RPA43_HUMAN","DNA-directed RNA polymerase I subunit RPA43",null,"TWISTNB"]
["18.6941",1,"18.1712","19.2305","17.5672","18.5301",{"$nulls":3},"DNA repair;oxidation-reduction process",{"$nulls":5},1,1,1,"13.4","13.4","13.4","12.055","0.00041322","4.1541",14106000,5,"0.426219",1,"-5.82083","-0.997946","tr|H0YJF3|H0YJF3_HUMAN;tr|G3V4M4|G3V4M4_HUMAN;sp|Q13686|ALKB1_HUMAN","tr|H0YJF3|H0YJF3_HUMAN;tr|G3V4M4|G3V4M4_HUMAN;sp|Q13686|ALKB1_HUMAN",2404,"H0YJF3","H0YJF3_HUMAN",null,null,"ALKBH1"]
[1,1,"17.6203","18.5781",1,"17.5141",{"$nulls":3},"generation of catalytic spliceosome for second transesterification step;nuclear retention of unspliced pre-mRNA at the site of transcription",null,"U2-type post-spliceosomal complex;U4/U6 x U5 tri-snRNP complex;U5 snRNP",{"$nulls":3},3,3,3,"26.1","26.1","26.1","23.131","0.0011786","3.2994",8580300,3,"0.297554",1,"-5.82399","-0.733332","tr|M0R3G1|M0R3G1_HUMAN;tr|Q5T9P7|Q5T9P7_HUMAN;sp|Q99633|PRP18_HUMAN;tr|Q5T9P8|Q5T9P8_HUMAN","tr|M0R3G1|M0R3G1_HUMAN;tr|Q5T9P7|Q5T9P7_HUMAN;sp|Q99633|PRP18_HUMAN;tr|Q5T9P8|Q5T9P8_HUMAN",4092,"M0R3G1","M0R3G1_HUMAN"]
[1,"17.4912","18.5777","18.6482","17.7779","18.1243",{"$nulls":3},"heterotrimeric G-protein complex assembly;negative regulation of protein refolding;protein folding;queuosine biosynthetic process;regulation of G-protein coupled receptor protein signaling pathway;signal transduction;visual perception","protein complex binding;signal transducer activity, downstream of receptor","cytoplasm;cytosol",{"$nulls":3},3,3,3,"10.6","10.6","10.6","34.281","0.00041641","4.3",37873000,5,"0.439068",1,"-5.82718","-1.02367","sp|Q13371|PHLP_HUMAN","sp|Q13371|PHLP_HUMAN",2344,"Q13371","PHLP_HUMAN","Phosducin-like protein","HLP","PDCL"]
[1,1,"16.081","18.6383",1,"15.9413",{"$nulls":9},2,2,2,16,16,16,"27.162","0.0011737","3.2602",13603000,2,"0.321574",1,"-5.83286","-0.783935","tr|I3L184|I3L184_HUMAN;tr|F6VX93|F6VX93_HUMAN;sp|Q5VIR6|VPS53_HUMAN;tr|E7EVT8|E7EVT8_HUMAN","tr|I3L184|I3L184_HUMAN;tr|F6VX93|F6VX93_HUMAN;sp|Q5VIR6|VPS53_HUMAN;tr|E7EVT8|E7EVT8_HUMAN",2893,"I3L184","I3L184_HUMAN",null,null,"VPS53"]
[1,"16.96",1,"16.8924","18.5906",1,{"$nulls":3},"DNA strand elongation involved in DNA replication",null,"nucleoplasm",{"$nulls":3},1,1,1,"6.9","6.9","6.9","24.534","0.00081251","3.831",34760000,1,"0.308301",1,"-5.84098","-0.756056","sp|Q9BRX5|PSF3_HUMAN","sp|Q9BRX5|PSF3_HUMAN",4177,"Q9BRX5","PSF3_HUMAN","DNA replication complex GINS protein PSF3",null,"GINS3"]
[1,"18.7411",1,"18.3305","18.9622",1,{"$nulls":5},"intracellular membrane-bounded organelle;nucleus;plasma membrane",{"$nulls":3},1,1,1,"8.2","8.2","8.2","16.279","0.0011876","3.424",24339000,5,"0.282501",1,"-5.85055","-0.701258","tr|G3V3Q0|G3V3Q0_HUMAN;tr|G3V5F9|G3V5F9_HUMAN;tr|G3V5B8|G3V5B8_HUMAN;tr|G3V554|G3V554_HUMAN;tr|G3V4W8|G3V4W8_HUMAN;tr|G3V2J6|G3V2J6_HUMAN;tr|G3V5H9|G3V5H9_HUMAN;tr|G3V2U6|G3V2U6_HUMAN;tr|Q9BRS7|Q9BRS7_HUMAN;tr|G3V2F4|G3V2F4_HUMAN;tr|E7EPD8|E7EPD8_HUMAN;sp|Q9NUW8|TYDP1_HUMAN","tr|G3V3Q0|G3V3Q0_HUMAN;tr|G3V5F9|G3V5F9_HUMAN;tr|G3V5B8|G3V5B8_HUMAN;tr|G3V554|G3V554_HUMAN;tr|G3V4W8|G3V4W8_HUMAN;tr|G3V2J6|G3V2J6_HUMAN;tr|G3V5H9|G3V5H9_HUMAN;tr|G3V2U6|G3V2U6_HUMAN;tr|Q9BRS7|Q9BRS7_HUMAN;tr|G3V2F4|G3V2F4_HUMAN;tr|E7EPD8|E7EPD8_HUMAN;sp|Q9NUW8|TYDP1_HUMAN",4745,"G3V3Q0","G3V3Q0_HUMAN",null,null,"TDP1"]
["19.7141",1,"19.4891","19.842","18.3993","19.5397",{"$nulls":3},"proteasome-mediated ubiquitin-dependent protein catabolic process;protein polyubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process","ubiquitin protein ligase activity",{"$nulls":4},4,4,4,"12.9","12.9","12.9","43.324",0,"6.1725",75748000,6,"0.398724",1,"-5.85927","-0.942551","sp|Q96B23|CR025_HUMAN;tr|Q5BIX2|Q5BIX2_HUMAN;tr|K7EQH1|K7EQH1_HUMAN;tr|A0A087WVF1|A0A087WVF1_HUMAN","sp|Q96B23|CR025_HUMAN;tr|Q5BIX2|Q5BIX2_HUMAN;tr|K7EQH1|K7EQH1_HUMAN;tr|A0A087WVF1|A0A087WVF1_HUMAN",3798,"Q96B23","CR025_HUMAN","Uncharacterized protein C18orf25",null,"C18orf25"]
[1,"14.8286",1,1,"16.6358","16.7953",{"$nulls":3},"activin receptor signaling pathway;cardiac epithelial to mesenchymal transition;endothelial cell activation;heart development;intracellular signal transduction;mesenchymal cell differentiation;positive regulation of endothelial cell proliferation;positive regulation of gene expression;positive regulation of transcription, DNA-templated;regulation of epithelial to mesenchymal transition;regulation of gene expression;transforming growth factor beta receptor signaling pathway","ATP binding;signal transducer activity, downstream of receptor;signal transducer, downstream of receptor, with serine/threonine kinase activity;transforming growth factor beta binding;transforming growth factor beta receptor activity, type I","cell;integral component of membrane;intracellular membrane-bounded organelle;membrane;plasma membrane",{"$nulls":3},2,2,2,"6.2","6.2","6.2","48.875","0.0011818","3.3322",14783000,3,"0.348961",1,"-5.86749","-0.840861","tr|B4DY26|B4DY26_HUMAN;sp|P36897|TGFR1_HUMAN;tr|F8W1R9|F8W1R9_HUMAN","tr|B4DY26|B4DY26_HUMAN;sp|P36897|TGFR1_HUMAN;tr|F8W1R9|F8W1R9_HUMAN",1489,"B4DY26","B4DY26_HUMAN","Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00410109}",null,"TGFBR1"]
[1,"15.9642",1,"18.0021","16.5761",1,{"$nulls":3},"aging;apoptotic DNA fragmentation;cellular response to calcium ion;cellular response to glucose stimulus;cellular response to hypoxia;DNA recombination;in utero embryonic development;neuron death in response to oxidative stress;positive regulation of apoptotic DNA fragmentation;positive regulation of hydrogen peroxide-mediated programmed cell death;response to antibiotic;response to estradiol;response to mechanical stimulus;response to tumor necrosis factor","deoxyribonuclease activity;endonuclease activity;metal ion binding;nucleic acid binding","cytosol;mitochondrion;nucleus;perikaryon","Apoptosis",null,null,2,2,2,"15.2","15.2","15.2","32.62","0.00042662","4.8326",13575000,2,"0.326906",1,"-5.87131","-0.79508","sp|Q14249|NUCG_HUMAN","sp|Q14249|NUCG_HUMAN",2461,"Q14249","NUCG_HUMAN","Endonuclease G, mitochondrial","ndo G","ENDOG"]
["19.8115","17.1575",1,"20.3221","17.5886","17.6737",{"$nulls":3},"axonogenesis;constitutive secretory pathway;evoked neurotransmitter secretion;glutamate secretion;lung development;maintenance of presynaptic active zone structure;mitochondrion organization;neuromuscular synaptic transmission;neurotransmitter secretion;neutrophil degranulation;positive regulation of exocytosis;positive regulation of regulated secretory pathway;post-embryonic development;post-translational protein modification;protein transport;regulation of short-term neuronal synaptic plasticity;regulation of synaptic vesicle fusion to presynaptic active zone membrane;respiratory system process;response to electrical stimulus;sensory perception of touch;synaptic vesicle exocytosis;synaptic vesicle maturation;synaptic vesicle recycling","ATPase activator activity;ATPase binding;GDP-dissociation inhibitor binding;GTP binding;GTPase activity;GTP-dependent protein binding;myosin V binding;protein C-terminus binding","acrosomal vesicle;anchored component of synaptic vesicle membrane;axon;clathrin-sculpted acetylcholine transport vesicle membrane;clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;clathrin-sculpted glutamate transport vesicle membrane;clathrin-sculpted monoamine transport vesicle membrane;cytosol;endosome;extracellular vesicle;plasma membrane;protein complex;secretory granule membrane;synaptic vesicle;terminal bouton","Insulin secretion;Synaptic vesicle cycle",null,null,3,2,2,"17.7","14.1","14.1","24.984",0,"5.8661",62024000,7,"0.420992",1,"-5.87179","-0.987452","sp|P20336|RAB3A_HUMAN;tr|S4R3Q3|S4R3Q3_HUMAN","sp|P20336|RAB3A_HUMAN;tr|S4R3Q3|S4R3Q3_HUMAN",1208,"P20336","RAB3A_HUMAN","Ras-related protein Rab-3A",null,"RAB3A"]
[1,"16.7977","18.0721","18.7395","16.2073","18.5448",{"$nulls":3},"positive regulation of I-kappaB kinase/NF-kappaB signaling","magnesium ion transmembrane transporter activity;palmitoyltransferase activity;protein-cysteine S-palmitoyltransferase activity;signal transducer activity","cytoplasmic vesicle membrane;endoplasmic reticulum;Golgi membrane;Golgi-associated vesicle membrane;integral component of membrane;membrane",{"$nulls":3},2,2,2,"5.6","5.6","5.6","70.86",0,"5.3554",38245000,4,"0.456417",1,"-5.87397","-1.05826","sp|Q8IUH4|ZDH13_HUMAN","sp|Q8IUH4|ZDH13_HUMAN",3279,"Q8IUH4","ZDH13_HUMAN","Palmitoyltransferase ZDHHC13 {ECO:0000305}",null,"ZDHHC13"]
["18.5871",1,"18.7321","19.9642","16.2604","19.7548",{"$nulls":3},"UDP-N-acetylglucosamine biosynthetic process","carbohydrate binding;identical protein binding;UDP-N-acetylglucosamine diphosphorylase activity","cytosol;nucleoplasm;plasma membrane","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,9,9,8,"26.1","26.1","23.6","58.768",0,"38.68",157970000,18,"0.417194",1,"-5.88674","-0.979817","sp|Q16222|UAP1_HUMAN","sp|Q16222|UAP1_HUMAN",2660,"Q16222","UAP1_HUMAN","UDP-N-acetylhexosamine pyrophosphorylase",null,"UAP1"]
[1,"16.3538","17.6799","18.6283","16.03","18.0401",{"$nulls":3},"signal transduction","GTPase activator activity","cytosol;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"9.8","9.8","9.8","58.404",0,"8.18",35319000,5,"0.471576",1,"-5.88823","-1.08837","tr|A0A0C4DGE6|A0A0C4DGE6_HUMAN;tr|E9PNT2|E9PNT2_HUMAN;tr|E9PIR1|E9PIR1_HUMAN;tr|A0A0G2JRG8|A0A0G2JRG8_HUMAN;tr|A0A0G2JNY3|A0A0G2JNY3_HUMAN;sp|Q6ZUM4|RHG27_HUMAN;tr|E9PNX6|E9PNX6_HUMAN","tr|A0A0C4DGE6|A0A0C4DGE6_HUMAN;tr|E9PNT2|E9PNT2_HUMAN;tr|E9PIR1|E9PIR1_HUMAN;tr|A0A0G2JRG8|A0A0G2JRG8_HUMAN;tr|A0A0G2JNY3|A0A0G2JNY3_HUMAN;sp|Q6ZUM4|RHG27_HUMAN",3089,"A0A0C4DGE6","A0A0C4DGE6_HUMAN",null,null,"ARHGAP27"]
[1,1,"17.2947","18.0784",1,"17.8973",{"$nulls":3},"tRNA methylation","tRNA (cytosine) methyltransferase activity",{"$nulls":4},1,1,1,"3.4","3.4","3.4","43.426","0.0026707","2.9279",17295000,3,"0.305953",1,"-5.89365","-0.751104","sp|Q6P1Q9|MET2B_HUMAN","sp|Q6P1Q9|MET2B_HUMAN",3003,"Q6P1Q9","MET2B_HUMAN","Methyltransferase-like protein 2B",null,"METTL2B"]
["16.2926",1,1,"17.8893",1,"17.1456",{"$nulls":4},"ATP binding;ATPase activity, coupled to transmembrane movement of substances","cytosol;Golgi apparatus;integral component of membrane;mitochondrion;nucleoplasm;plasma membrane",{"$nulls":3},3,3,3,"9.1","9.1","9.1","77.434",0,"7.4314",17171000,3,"0.32346",1,"-5.9141","-0.78788","tr|H7BXK9|H7BXK9_HUMAN;sp|Q9NP58|ABCB6_HUMAN","tr|H7BXK9|H7BXK9_HUMAN;sp|Q9NP58|ABCB6_HUMAN",4620,"H7BXK9","H7BXK9_HUMAN",null,null,"ABCB6"]
["17.7562",1,"18.3625","19.3238","17.6116","17.9304",{"$nulls":3},"maturation of SSU-rRNA;positive regulation of ribosomal small subunit export from nucleus;positive regulation of rRNA processing;ribosomal small subunit biogenesis;rRNA processing","ATP binding;metal ion binding;protein serine/threonine kinase activity","cytoplasm;cytosol;nucleoplasm;preribosome, small subunit precursor","Ribosome biogenesis in eukaryotes",null,null,7,7,7,"18.8","18.8","18.8","63.282",0,"31.088",216690000,29,"0.444946",1,"-5.9157","-1.03541","sp|Q9BVS4|RIOK2_HUMAN;tr|H0Y919|H0Y919_HUMAN","sp|Q9BVS4|RIOK2_HUMAN",4262,"Q9BVS4","RIOK2_HUMAN","Serine/threonine-protein kinase RIO2",null,"RIOK2"]
[1,"12.8825",1,"15.9552",1,"15.6812",{"$nulls":3},"microtubule nucleation","gamma-tubulin binding","microtubule organizing center;spindle pole",{"$nulls":3},2,2,2,"1.7","1.7","1.7","163.91","0.0013582","3.1782",15488000,2,"0.394816",1,"-5.91796","-0.934636","tr|E7EQL8|E7EQL8_HUMAN;sp|Q96RT7|GCP6_HUMAN","tr|E7EQL8|E7EQL8_HUMAN;sp|Q96RT7|GCP6_HUMAN",4026,"E7EQL8","E7EQL8_HUMAN",null,null,"TUBGCP6"]
["13.587","13.4741",1,"14.032","13.4423","18.3557",{"$nulls":3},"cAMP-mediated signaling;MAPK cascade;positive regulation of MAPK cascade;protein phosphorylation;Ras protein signal transduction","ATP binding;MAP-kinase scaffold activity;metal ion binding;protein C-terminus binding;protein kinase activity;signal transducer activity","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;membrane;protein complex;ruffle membrane","C-type lectin receptor signaling pathway;Ras signaling pathway;Tuberculosis",null,null,4,4,4,"6.8","6.8","6.8","102.16",0,"22.385",76241000,8,"0.594439",1,"-5.92295","-1.32954","sp|Q8IVT5|KSR1_HUMAN;tr|A0A0A0MQW1|A0A0A0MQW1_HUMAN;tr|A8MY87|A8MY87_HUMAN;tr|J3QR75|J3QR75_HUMAN","sp|Q8IVT5|KSR1_HUMAN;tr|A0A0A0MQW1|A0A0A0MQW1_HUMAN;tr|A8MY87|A8MY87_HUMAN",3297,"Q8IVT5","KSR1_HUMAN","Kinase suppressor of Ras 1",null,"KSR1"]
["23.2233","21.5944",1,"21.2582","21.2748","21.058",{"$nulls":3},"transcription initiation from RNA polymerase II promoter",null,"transcription factor TFIIA complex",{"$nulls":3},1,1,1,"13.2","13.2","13.2","7.7969","0.0048535","2.5478",72714000,7,"0.342912",1,"-5.92446","-0.828353","tr|A8MYR4|A8MYR4_HUMAN;tr|H0YK39|H0YK39_HUMAN;sp|P52657|T2AG_HUMAN","tr|A8MYR4|A8MYR4_HUMAN;tr|H0YK39|H0YK39_HUMAN;sp|P52657|T2AG_HUMAN",1775,"A8MYR4","A8MYR4_HUMAN",null,null,"GTF2A2"]
[1,"16.3258","17.5462","19.478","16.2533","16.92",{"$nulls":3},"activation of cysteine-type endopeptidase activity;activation of cysteine-type endopeptidase activity involved in apoptotic process;ADP metabolic process;apoptotic process;ATP metabolic process;cellular process regulating host cell cycle in response to virus;cellular response to chromate;cellular response to hypoxia;cellular response to lipid;cellular response to mechanical stimulus;cellular response to nicotine;cerebral cortex development;cytokine-mediated signaling pathway;extrinsic apoptotic signaling pathway;extrinsic apoptotic signaling pathway in absence of ligand;extrinsic apoptotic signaling pathway via death domain receptors;glucose catabolic process;glucose homeostasis;intrinsic apoptotic signaling pathway;intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of cytolysis;pore complex assembly;positive regulation of apoptotic process;positive regulation of apoptotic process by virus;positive regulation of autophagy;positive regulation of B cell differentiation;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of epithelial cell proliferation;positive regulation of glucokinase activity;positive regulation of insulin secretion;positive regulation of insulin secretion involved in cellular response to glucose stimulus;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;positive regulation of mitochondrial membrane potential;positive regulation of neuron death;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;positive regulation of proteolysis;positive regulation of release of cytochrome c from mitochondria;positive regulation of T cell differentiation;positive regulation of type B pancreatic cell development;protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;regulation of mitochondrial membrane permeability;release of cytochrome c from mitochondria;response to amino acid;response to calcium ion;response to drug;response to estradiol;response to ethanol;response to glucocorticoid;response to glucose;response to hydrogen peroxide;response to oleic acid;response to progesterone;response to testosterone;spermatogenesis;suppression by virus of host apoptotic process;type B pancreatic cell proliferation","14-3-3 protein binding;cysteine-type endopeptidase activator activity involved in apoptotic process;lipid binding;phospholipid binding;protein heterodimerization activity;protein kinase B binding;protein kinase binding;protein phosphatase 2B binding","cytosol;mitochondrial outer membrane;mitochondrion","Acute myeloid leukemia;Alzheimer disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Autophagy - animal;cAMP signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Chronic myeloid leukemia;Colorectal cancer;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Focal adhesion;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Insulin signaling pathway;Measles;Melanoma;Neurotrophin signaling pathway;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;PI3K-Akt signaling pathway;Platinum drug resistance;Prostate cancer;Ras signaling pathway;Renal cell carcinoma;Thyroid hormone signaling pathway;Toxoplasmosis;Tuberculosis;VEGF signaling pathway;Viral carcinogenesis",null,null,2,2,2,"14.3","14.3","14.3","18.392",0,"6.2058",21231000,3,"0.474776",1,"-5.92638","-1.09471","sp|Q92934|BAD_HUMAN;tr|F5GYS3|F5GYS3_HUMAN;tr|A8MXU7|A8MXU7_HUMAN","sp|Q92934|BAD_HUMAN;tr|F5GYS3|F5GYS3_HUMAN;tr|A8MXU7|A8MXU7_HUMAN",3740,"Q92934","BAD_HUMAN","Bcl2-associated agonist of cell death","AD","BAD"]
["18.5133",1,"18.5659","19.6216","17.0349","19.3236",{"$nulls":3},"ceramide biosynthetic process;sphingolipid biosynthetic process","DNA binding;sphingosine N-acyltransferase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;nuclear membrane","Metabolic pathways;Sphingolipid metabolism;Sphingolipid signaling pathway",null,null,2,2,2,"4.7","4.7","4.7","44.889",0,"7.1626",53709000,9,"0.43262",1,"-5.96698","-1.01077","sp|Q6ZMG9|CERS6_HUMAN","sp|Q6ZMG9|CERS6_HUMAN",3077,"Q6ZMG9","CERS6_HUMAN","Ceramide synthase 6","erS6","CERS6"]
[1,"14.5005",1,"18.2158","15.1873",1,{"$nulls":9},3,3,3,"10.6","10.6","10.6","42.321",0,"6.2934",9582600,2,"0.357127",1,"-5.96752","-0.857693","sp|Q9H4I3|TRABD_HUMAN;tr|J3KPT4|J3KPT4_HUMAN","sp|Q9H4I3|TRABD_HUMAN;tr|J3KPT4|J3KPT4_HUMAN",4468,"Q9H4I3","TRABD_HUMAN","TraB domain-containing protein",null,"TRABD"]
["16.1513",1,1,"17.8999",1,"17.2316",{"$nulls":3},"histone H4-K16 acetylation",null,"MSL complex;nucleoplasm",{"$nulls":3},4,4,4,15,15,15,"48.976",0,"19.283",89685000,18,"0.329575",1,"-5.9934","-0.800647","tr|J3QQY0|J3QQY0_HUMAN;tr|J3KSZ8|J3KSZ8_HUMAN;sp|Q68DK7|MSL1_HUMAN;tr|J3KRQ4|J3KRQ4_HUMAN","tr|J3QQY0|J3QQY0_HUMAN;tr|J3KSZ8|J3KSZ8_HUMAN;sp|Q68DK7|MSL1_HUMAN",2934,"J3QQY0","J3QQY0_HUMAN",null,null,"MSL1"]
[1,"17.9631","19.4061","19.0031","17.9657","19.3969",{"$nulls":9},2,2,2,"19.5","19.5","19.5","17.465","0.0013571","3.1648",35186000,4,"0.433464",1,"-5.99881","-1.01246","sp|Q96AT1|K1143_HUMAN","sp|Q96AT1|K1143_HUMAN",3794,"Q96AT1","K1143_HUMAN","Uncharacterized protein KIAA1143",null,"KIAA1143"]
[1,"12.9275","17.3485","17.4959","14.5936","17.1836",{"$nulls":3},"cellular response to leukemia inhibitory factor;cysteine biosynthetic process;cysteine biosynthetic process via cystathionine;cysteine metabolic process;'de novo' L-methionine biosynthetic process;endoplasmic reticulum unfolded protein response;hydrogen sulfide biosynthetic process;negative regulation of apoptotic signaling pathway;positive regulation of aortic smooth muscle cell differentiation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;protein homotetramerization;protein sulfhydration;protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine;sulfur amino acid catabolic process;transsulfuration","calmodulin binding;carbon-sulfur lyase activity;cystathionine gamma-lyase activity;cystathionine gamma-synthase activity;homocysteine desulfhydrase activity;identical protein binding;L-cysteine desulfhydrase activity;L-cystine L-cysteine-lyase (deaminating);pyridoxal phosphate binding","cytoplasm;cytosol;extracellular exosome","Biosynthesis of amino acids;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways;Selenocompound metabolism",null,null,2,2,2,"8.4","8.4","8.4","44.508",0,"36.838",29661000,7,"0.531994",1,"-5.99903","-1.20746","sp|P32929|CGL_HUMAN","sp|P32929|CGL_HUMAN",1429,"P32929","CGL_HUMAN","Cystathionine gamma-lyase",null,"CTH"]
[1,"14.9767","17.2652","17.5202","15.3476","18.3861",{"$nulls":3},"DNA-templated transcription, initiation","DNA binding",{"$nulls":4},4,4,4,"18.1","18.1","18.1","31.616",0,"34.698",193130000,17,"0.509295",1,"-6.00401","-1.16286","tr|Q32MN6|Q32MN6_HUMAN;sp|P20226|TBP_HUMAN;tr|H0Y6D8|H0Y6D8_HUMAN;sp|Q6SJ96|TBPL2_HUMAN","tr|Q32MN6|Q32MN6_HUMAN;sp|P20226|TBP_HUMAN;tr|H0Y6D8|H0Y6D8_HUMAN;sp|Q6SJ96|TBPL2_HUMAN",1205,"Q32MN6","Q32MN6_HUMAN"]
["21.0831","18.7206",1,"21.2759","17.8613","19.7337",{"$nulls":9},4,4,4,"36.1","36.1","36.1","20.987",0,22,81015000,6,"0.396956",1,"-6.02243","-0.938973","tr|E9PPQ1|E9PPQ1_HUMAN;sp|Q16890|TPD53_HUMAN;tr|J3KNE7|J3KNE7_HUMAN;tr|E9PNK6|E9PNK6_HUMAN;tr|E9PNQ9|E9PNQ9_HUMAN","tr|E9PPQ1|E9PPQ1_HUMAN;sp|Q16890|TPD53_HUMAN;tr|J3KNE7|J3KNE7_HUMAN;tr|E9PNK6|E9PNK6_HUMAN;tr|E9PNQ9|E9PNQ9_HUMAN",2706,"E9PPQ1","E9PPQ1_HUMAN",null,null,"TPD52L1"]
["18.1151",1,"19.4131","21.4779","15.6886","19.4542",{"$nulls":9},4,4,4,"45.1","45.1","45.1","13.104",0,"11.872",48400000,10,"0.415943",1,"-6.03085","-0.977301","sp|Q9BT73|PSMG3_HUMAN","sp|Q9BT73|PSMG3_HUMAN",4198,"Q9BT73","PSMG3_HUMAN","Proteasome assembly chaperone 3","AC-3;PAC3","PSMG3"]
[1,1,"19.0664","19.3221",1,"18.8562",{"$nulls":3},"DNA damage checkpoint;DNA repair;glycoprotein catabolic process;post-translational protein modification;protein polyubiquitination;proteolysis;response to unfolded protein;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;ubiquitin-dependent ERAD pathway","carbohydrate binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;endoplasmic reticulum quality control compartment;SCF ubiquitin ligase complex","Protein processing in endoplasmic reticulum",null,null,2,2,2,"11.9","11.9","11.9","33.932",0,"13.058",32342000,4,"0.285817",1,"-6.03728","-0.70835","sp|Q9NRD1|FBX6_HUMAN;tr|J3KQ72|J3KQ72_HUMAN","sp|Q9NRD1|FBX6_HUMAN;tr|J3KQ72|J3KQ72_HUMAN",4686,"Q9NRD1","FBX6_HUMAN","F-box only protein 6",null,"FBXO6"]
["19.7359","17.8929",1,"19.953","17.7471","19.0464",{"$nulls":9},1,1,1,"11.4","11.4","11.4","20.206",0,"6.5259",40943000,4,"0.430827",1,"-6.03925","-1.00718","tr|A0A087X2F5|A0A087X2F5_HUMAN;sp|Q9NZ63|CI078_HUMAN","tr|A0A087X2F5|A0A087X2F5_HUMAN;sp|Q9NZ63|CI078_HUMAN",4869,"A0A087X2F5"]
[1,"16.6566","17.7876","18.4833","17.0902","17.9925",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;RNA export from nucleus;RNA splicing;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus","RNA binding","nuclear speck;nucleoplasm;THO complex part of transcription export complex;transcription export complex","RNA transport;Spliceosome",null,null,6,6,6,"19.1","19.1","19.1","38.771",0,"18.145",142230000,20,"0.483473",1,"-6.04059","-1.11192","sp|Q96J01|THOC3_HUMAN;tr|D6REC9|D6REC9_HUMAN;tr|D6RGZ2|D6RGZ2_HUMAN;tr|H7C0C5|H7C0C5_HUMAN","sp|Q96J01|THOC3_HUMAN;tr|D6REC9|D6REC9_HUMAN",3933,"Q96J01","THOC3_HUMAN","THO complex subunit 3","ho3","THOC3"]
[1,"15.7773","16.0969","17.7511","15.7934","17.458",{"$nulls":4},"GTPase activator activity;metal ion binding",{"$nulls":4},6,6,5,"8.1","8.1","7.2","124.77",0,"18.349",66162000,14,"0.530459",1,"-6.04277","-1.20445","tr|A0A0A0MRE5|A0A0A0MRE5_HUMAN;sp|Q9ULH1|ASAP1_HUMAN;tr|H0YBF7|H0YBF7_HUMAN;tr|E5RHD7|E5RHD7_HUMAN;tr|H0YBM4|H0YBM4_HUMAN","tr|A0A0A0MRE5|A0A0A0MRE5_HUMAN;sp|Q9ULH1|ASAP1_HUMAN;tr|H0YBF7|H0YBF7_HUMAN",5122,"A0A0A0MRE5","A0A0A0MRE5_HUMAN",null,null,"ASAP1"]
[1,"18.6276","18.3124","19.6743","17.471","18.9806",{"$nulls":3},"DNA replication;maintenance of mitotic sister chromatid cohesion;positive regulation of DNA-directed DNA polymerase activity;post-translational protein acetylation;regulation of DNA replication","DNA binding","chromatin;chromosome, centromeric region;Ctf18 RFC-like complex;nucleoplasm",{"$nulls":3},3,3,3,"10.9","10.9","10.9","44.825",0,"11.814",73609000,12,"0.444447",1,"-6.06193","-1.03441","sp|Q9BVC3|DCC1_HUMAN","sp|Q9BVC3|DCC1_HUMAN",4245,"Q9BVC3","DCC1_HUMAN","Sister chromatid cohesion protein DCC1",null,"DSCC1"]
["17.436","15.3541",1,"16.8759","20.4193","14.7193",{"$nulls":3},"7-methylguanosine mRNA capping;DNA repair;global genome nucleotide-excision repair;nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;phosphorylation of RNA polymerase II C-terminal domain;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair","damaged DNA binding;DNA binding transcription factor activity;metal ion binding;protein N-terminus binding;translation factor activity, RNA binding","core TFIIH complex portion of holo TFIIH complex;holo TFIIH complex;nucleoplasm;nucleus;transcription factor TFIID complex;transcriptional preinitiation complex","Basal transcription factors;Nucleotide excision repair;Viral carcinogenesis",null,null,7,7,7,"34.1","34.1","34.1","34.378",0,"46.217",234110000,28,"0.487199",1,"-6.07479","-1.11929","sp|Q13889|TF2H3_HUMAN;tr|F5GWD3|F5GWD3_HUMAN;tr|F5GXG6|F5GXG6_HUMAN;tr|H0YFF7|H0YFF7_HUMAN;tr|F5GX35|F5GX35_HUMAN;tr|F5H4K7|F5H4K7_HUMAN;tr|F5H6X0|F5H6X0_HUMAN;tr|A0A087WYD5|A0A087WYD5_HUMAN","sp|Q13889|TF2H3_HUMAN;tr|F5GWD3|F5GWD3_HUMAN;tr|F5GXG6|F5GXG6_HUMAN;tr|H0YFF7|H0YFF7_HUMAN;tr|F5GX35|F5GX35_HUMAN;tr|F5H4K7|F5H4K7_HUMAN;tr|F5H6X0|F5H6X0_HUMAN",2420,"Q13889","TF2H3_HUMAN","General transcription factor IIH subunit 3",null,"GTF2H3"]
[1,"19.8986","19.3519","19.6226","19.5431","19.3203",{"$nulls":3},"cellular protein modification process;tail-anchored membrane protein insertion into ER membrane","chaperone binding;ubiquitin-like protein transferase activity","BAT3 complex;cytoplasm;cytosol;membrane;nucleus",{"$nulls":3},3,3,3,"21.7","21.7","21.7","17.776",0,"5.4138",56950000,3,"0.416617",1,"-6.07851","-0.978656","sp|P11441|UBL4A_HUMAN;tr|Q5HY81|Q5HY81_HUMAN;tr|F8WB70|F8WB70_HUMAN","sp|P11441|UBL4A_HUMAN;tr|Q5HY81|Q5HY81_HUMAN",1049,"P11441","UBL4A_HUMAN","Ubiquitin-like protein 4A",null,"UBL4A"]
["18.8695","16.2331",1,"19.7013","16.8864","17.7708",{"$nulls":3},"proton-transporting ATP synthase complex assembly",null,"cytosol;mitochondrion;nuclear speck",{"$nulls":3},4,4,4,"19.7","19.7","19.7","32.772",0,"68.156",44010000,6,"0.467693",1,"-6.08527","-1.08067","sp|Q8N5M1|ATPF2_HUMAN;tr|C9J2Q2|C9J2Q2_HUMAN;tr|K7ELC1|K7ELC1_HUMAN","sp|Q8N5M1|ATPF2_HUMAN;tr|C9J2Q2|C9J2Q2_HUMAN",3417,"Q8N5M1","ATPF2_HUMAN","ATP synthase mitochondrial F1 complex assembly factor 2",null,"ATPAF2"]
["17.7177",1,"18.0254","18.6536","18.2805","18.0686",{"$nulls":4},"methyltransferase activity",{"$nulls":4},2,2,2,"15.8","15.8","15.8","18.052","0.0013659","3.226",31745000,3,"0.468183",1,"-6.08654","-1.08164","tr|I3L4A2|I3L4A2_HUMAN;sp|Q9UIC8|LCMT1_HUMAN;tr|I3L2E3|I3L2E3_HUMAN","tr|I3L4A2|I3L4A2_HUMAN;sp|Q9UIC8|LCMT1_HUMAN;tr|I3L2E3|I3L2E3_HUMAN",5048,"I3L4A2","I3L4A2_HUMAN",null,null,"LCMT1"]
["19.681",1,1,"19.5989",1,"19.3567",{"$nulls":3},"mRNA splice site selection","mRNA binding","U1 snRNP",{"$nulls":3},12,1,0,"28.2","2.4",0,"54.223",0,"6.9792",78280000,6,"0.279802",1,"-6.09153","-0.695475","tr|A0A0A6YYJ8|A0A0A6YYJ8_HUMAN","tr|A0A0A6YYJ8|A0A0A6YYJ8_HUMAN",5453,"A0A0A6YYJ8","A0A0A6YYJ8_HUMAN",null,null,"LUC7L2"]
["23.061","20.2247",1,"22.1263","20.1535","20.2899",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","RNA binding","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion",{"$nulls":3},6,3,3,"42.8",23,23,"20.843",0,"60.586",305040000,16,"0.365963",1,"-6.09463","-0.875837","sp|Q9Y2Q9|RT28_HUMAN;tr|H0YAT2|H0YAT2_HUMAN;tr|E5RGC7|E5RGC7_HUMAN;tr|H7C5V3|H7C5V3_HUMAN;tr|E5RFH3|E5RFH3_HUMAN;tr|U3KQQ8|U3KQQ8_HUMAN;tr|E5RK86|E5RK86_HUMAN;tr|E5RFT8|E5RFT8_HUMAN","sp|Q9Y2Q9|RT28_HUMAN;tr|H0YAT2|H0YAT2_HUMAN;tr|E5RGC7|E5RGC7_HUMAN;tr|H7C5V3|H7C5V3_HUMAN;tr|E5RFH3|E5RFH3_HUMAN",5233,"Q9Y2Q9","RT28_HUMAN","28S ribosomal protein S28, mitochondrial","28mt;RP-S28","MRPS28"]
[1,1,"18.672","19.0243",1,"18.9364",{"$nulls":3},"brain development;carbohydrate phosphorylation;learning or memory;neuromuscular process;neuron migration;protein O-linked glycosylation;sensory perception of pain","ATP binding;carbohydrate kinase activity;phosphotransferase activity, alcohol group as acceptor;protein kinase activity","endoplasmic reticulum membrane;integral component of membrane","Mannose type O-glycan biosynthesis;Metabolic pathways",null,null,1,1,1,"5.4","5.4","5.4","40.05","0.00041203","4.1149",23008000,3,"0.293829",1,"-6.09623","-0.725423","sp|Q9H5K3|SG196_HUMAN","sp|Q9H5K3|SG196_HUMAN",4479,"Q9H5K3","SG196_HUMAN","Protein O-mannose kinase","OMK","POMK"]
[1,"17.8236","19.4097","19.2676","17.9964","19.2625",{"$nulls":3},"iron-sulfur cluster assembly","iron ion binding;iron-sulfur cluster binding",{"$nulls":4},1,1,1,"5.2","5.2","5.2","16.64","0.0096399","2.2102",34231000,3,"0.443538",1,"-6.09771","-1.0326","tr|F5H5N2|F5H5N2_HUMAN;tr|B4DNC9|B4DNC9_HUMAN;tr|B3KQ30|B3KQ30_HUMAN;sp|Q9H1K1|ISCU_HUMAN","tr|F5H5N2|F5H5N2_HUMAN;tr|B4DNC9|B4DNC9_HUMAN;tr|B3KQ30|B3KQ30_HUMAN;sp|Q9H1K1|ISCU_HUMAN",4417,"F5H5N2","F5H5N2_HUMAN",null,null,"ISCU"]
["20.1808","20.4099",1,"20.3816","19.7812","19.7667",{"$nulls":3},"ATP biosynthetic process;negative regulation of ATP citrate synthase activity;oxidative phosphorylation;positive regulation of high voltage-gated calcium channel activity",null,"integral component of plasma membrane;membrane;mitochondrial outer membrane;mitochondrion",{"$nulls":3},3,3,3,"13.6","13.6","13.6","33.742",0,"9.5019",158470000,8,"0.402359",1,"-6.11293","-0.949904","sp|O75323|NIPS2_HUMAN;tr|H7C333|H7C333_HUMAN;tr|C9J7B1|C9J7B1_HUMAN;tr|C9K068|C9K068_HUMAN;tr|F8WBI5|F8WBI5_HUMAN","sp|O75323|NIPS2_HUMAN;tr|H7C333|H7C333_HUMAN",566,"O75323","NIPS2_HUMAN","Protein NipSnap homolog 2","ipSnap2","NIPSNAP2"]
[1,"18.3503","18.8973","19.9428","17.9503","18.7237",{"$nulls":3},"RNA phosphodiester bond hydrolysis, endonucleolytic;rRNA processing;tRNA 5'-leader removal;tRNA processing","ribonuclease P activity;RNA binding","multimeric ribonuclease P complex;nucleolar ribonuclease P complex;nucleoplasm;nucleus;ribonuclease MRP complex","Ribosome biogenesis in eukaryotes;RNA transport",null,null,7,7,7,"35.1","35.1","35.1","29.321",0,"28.274",294980000,35,"0.445681",1,"-6.12304","-1.03688","sp|P78346|RPP30_HUMAN;tr|Q5VU11|Q5VU11_HUMAN;tr|Q5VU10|Q5VU10_HUMAN","sp|P78346|RPP30_HUMAN;tr|Q5VU11|Q5VU11_HUMAN;tr|Q5VU10|Q5VU10_HUMAN",2057,"P78346","RPP30_HUMAN","Ribonuclease P protein subunit p30","NaseP protein p30","RPP30"]
[1,1,"18.1818","19.5538",1,"18.0896",{"$nulls":3},"tRNA wobble uridine modification",null,"Elongator holoenzyme complex",{"$nulls":3},2,2,2,"16.2","16.2","16.2","19.976","0.0028398","2.7777",17986000,2,"0.302963",1,"-6.15388","-0.744787","tr|E9PPJ9|E9PPJ9_HUMAN;sp|Q96EB1|ELP4_HUMAN;tr|G5E9D4|G5E9D4_HUMAN","tr|E9PPJ9|E9PPJ9_HUMAN;sp|Q96EB1|ELP4_HUMAN;tr|G5E9D4|G5E9D4_HUMAN",3848,"E9PPJ9","E9PPJ9_HUMAN",null,null,"ELP4"]
[1,"18.4682",1,"20.0364","17.8936",1,{"$nulls":3},"termination of RNA polymerase II transcription","RNA polymerase II transcription cofactor activity;ubiquitin protein ligase activity","core mediator complex;mediator complex;ubiquitin ligase complex",{"$nulls":3},2,2,2,"9.6","9.6","9.6","23.662","0.00042617","4.8036",34028000,3,"0.29823",1,"-6.15394","-0.734766","sp|Q9BUE0|MED18_HUMAN","sp|Q9BUE0|MED18_HUMAN",4222,"Q9BUE0","MED18_HUMAN","Mediator of RNA polymerase II transcription subunit 18",null,"MED18"]
["17.2824","19.8232",1,"18.1382","19.1968","19.2594",{"$nulls":3},"cell migration;glycosaminoglycan biosynthetic process;glycosaminoglycan catabolic process;glycosaminoglycan metabolic process;inner ear receptor stereocilium organization;leukocyte migration;negative regulation of T cell proliferation;neural tube closure;positive regulation of exosomal secretion;positive regulation of extracellular exosome assembly;positive regulation of focal adhesion assembly;positive regulation of protein kinase activity;positive regulation of stress fiber assembly;regulation of fibroblast migration;retinoid metabolic process;ureteric bud development;wound healing","fibronectin binding;identical protein binding;protein kinase C binding;thrombospondin receptor activity","cell surface;costamere;extracellular exosome;focal adhesion;Golgi lumen;integral component of plasma membrane;lysosomal lumen;membrane raft;plasma membrane","Cell adhesion molecules (CAMs);ECM-receptor interaction;Fluid shear stress and atherosclerosis;Proteoglycans in cancer",null,null,3,3,3,"20.2","20.2","20.2","21.641",0,"8.5365",65898000,2,"0.448833",1,"-6.16293","-1.04316","sp|P31431|SDC4_HUMAN","sp|P31431|SDC4_HUMAN",1405,"P31431","SDC4_HUMAN","Syndecan-4","YND4","SDC4"]
["20.4521","17.6762",1,"20.5374","17.7047","19.383",{"$nulls":9},1,1,1,"24.4","24.4","24.4","8.7359",0,"13.38",22943000,5,"0.430152",1,"-6.16563","-1.00583","tr|E9PJ38|E9PJ38_HUMAN;tr|E9PND3|E9PND3_HUMAN;tr|E9PN10|E9PN10_HUMAN;sp|O00559|RCAS1_HUMAN","tr|E9PJ38|E9PJ38_HUMAN;tr|E9PND3|E9PND3_HUMAN;tr|E9PN10|E9PN10_HUMAN;sp|O00559|RCAS1_HUMAN",252,"E9PJ38","E9PJ38_HUMAN",null,null,"EBAG9"]
["15.5715",1,1,"18.6384",1,"16.4964",{"$nulls":3},"chromosome condensation",null,"cell junction;intercellular bridge;nucleoplasm;nucleus",{"$nulls":3},5,5,3,"12.7","12.7","6.6","66.257",0,"38.104",116490000,16,"0.347765",1,"-6.18775","-0.838392","tr|A0A0A6YYG7|A0A0A6YYG7_HUMAN;sp|Q6IBW4|CNDH2_HUMAN;tr|H0YC55|H0YC55_HUMAN","tr|A0A0A6YYG7|A0A0A6YYG7_HUMAN;sp|Q6IBW4|CNDH2_HUMAN",2961,"A0A0A6YYG7","A0A0A6YYG7_HUMAN",null,null,"NCAPH2"]
[1,"17.5971","17.1595","17.9225","18.6645","17.78",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","double-stranded DNA binding;identical protein binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","nucleoplasm;nucleus",{"$nulls":3},2,2,2,"11.4","11.4","11.4","18.82","0.0011976","3.5367",43397000,5,"0.49493",1,"-6.20348","-1.13456","sp|Q9UFW8|CGBP1_HUMAN;tr|C9JUJ0|C9JUJ0_HUMAN","sp|Q9UFW8|CGBP1_HUMAN;tr|C9JUJ0|C9JUJ0_HUMAN",4997,"Q9UFW8","CGBP1_HUMAN","CGG triplet repeat-binding protein 1","GG-binding protein 1","CGGBP1"]
["20.237",1,1,"21.0275","18.9333",1,{"$nulls":3},"post-translational protein modification;regulation of proteasomal ubiquitin-dependent protein catabolic process",null,"Cul4-RING E3 ubiquitin ligase complex;nucleoplasm",{"$nulls":3},1,1,1,"11.8","11.8","11.8","11.835","0.0013651","3.215",87008000,6,"0.277853",1,"-6.24127","-0.691293","sp|Q9BW61|DDA1_HUMAN","sp|Q9BW61|DDA1_HUMAN",4270,"Q9BW61","DDA1_HUMAN","DET1- and DDB1-associated protein 1",null,"DDA1"]
["17.3339","13.5006",1,"17.8066","13.8418","18.9104",{"$nulls":3},"proteolysis","cysteine-type peptidase activity;pyroglutamyl-peptidase activity","cytosol",{"$nulls":3},1,1,1,"7.7","7.7","7.7","23.138",0,"6.8961",11175000,3,"0.532351",1,"-6.24141","-1.20816","sp|Q9NXJ5|PGPI_HUMAN","sp|Q9NXJ5|PGPI_HUMAN",4830,"Q9NXJ5","PGPI_HUMAN","Pyroglutamyl-peptidase 1",null,"PGPEP1"]
[1,"20.0691","19.4524","19.7756","19.9785","19.5197",{"$nulls":5},"nucleus",{"$nulls":3},1,1,1,"5.8","5.8","5.8","25.977",0,"6.7493",119620000,15,"0.426709",1,"-6.2508","-0.998927","sp|Q8IYL3|CA174_HUMAN","sp|Q8IYL3|CA174_HUMAN",3342,"Q8IYL3","CA174_HUMAN","UPF0688 protein C1orf174",null,"C1orf174"]
["19.8071","19.1048",1,"20.0655","19.0144","19.6171",{"$nulls":3},"copper ion homeostasis;Golgi to plasma membrane transport;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein localization to cell surface;negative regulation of sodium ion transmembrane transport;plasma membrane to endosome transport;positive regulation of protein ubiquitination;post-translational protein modification;protein transport;protein ubiquitination;regulation of proteasomal ubiquitin-dependent protein catabolic process;transcription, DNA-templated","copper ion binding;identical protein binding;phosphatidic acid binding;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-4,5-bisphosphate binding;protein homodimerization activity","Cul2-RING ubiquitin ligase complex;cytoplasm;cytosol;early endosome;endosome membrane;extracellular exosome;nucleoplasm;nucleus;recycling endosome",{"$nulls":3},1,1,1,"7.4","7.4","7.4","21.178","0.0011952","3.5041",58122000,7,"0.435254",1,"-6.26173","-1.01605","sp|Q8N668|COMD1_HUMAN","sp|Q8N668|COMD1_HUMAN",3422,"Q8N668","COMD1_HUMAN","COMM domain-containing protein 1",null,"COMMD1"]
[1,"15.2677","14.3442","17.7116","15.8845","15.9",{"$nulls":3},"establishment of centrosome localization;nuclear migration;positive regulation of stress fiber assembly;positive regulation of transcription from RNA polymerase II promoter;regulation of stress fiber assembly","actin binding;identical protein binding;protein domain specific binding;protein self-association","bleb;cytoplasm;cytoskeleton;cytosol;intercalated disc;membrane;nucleus",{"$nulls":3},8,8,8,"11.3","11.3","11.3","126.55",0,"24.276",91971000,16,"0.60692",1,"-6.29471","-1.35387","sp|Q9Y613|FHOD1_HUMAN;tr|J3KTH7|J3KTH7_HUMAN","sp|Q9Y613|FHOD1_HUMAN",5382,"Q9Y613","FHOD1_HUMAN","FH1/FH2 domain-containing protein 1",null,"FHOD1"]
[1,"20.8103","20.4282","20.7779","20.0752","20.2894",{"$nulls":3},"tRNA processing",null,"EKC/KEOPS complex;nuclear body;nucleoplasm",{"$nulls":3},1,1,1,"16.1","16.1","16.1","14.804","0.0039422","2.6583",56659000,4,"0.408808",1,"-6.30136","-0.962925","sp|Q14657|LAGE3_HUMAN","sp|Q14657|LAGE3_HUMAN",2486,"Q14657","LAGE3_HUMAN","EKC/KEOPS complex subunit LAGE3",null,"LAGE3"]
[1,"21.063","20.2454","20.6439","20.5336","20.0352",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial ribosome;mitochondrial small ribosomal subunit","Ribosome",null,null,3,3,3,"20.3","20.3","20.3","15.173",0,"9.0995",1042900000,31,"0.407769",1,"-6.30144","-0.96083","sp|O15235|RT12_HUMAN","sp|O15235|RT12_HUMAN",352,"O15235","RT12_HUMAN","28S ribosomal protein S12, mitochondrial","12mt;RP-S12","MRPS12"]
[1,"20.0342","20.0528","20.4253","19.4095","20.1642",{"$nulls":3},"assembly of large subunit precursor of preribosome;ribosomal large subunit assembly;translation","RNA binding;structural constituent of ribosome","cytosolic large ribosomal subunit;nucleolus;nucleus","Ribosome",null,null,2,2,2,"16.6","16.6","16.6","19.621","0.00041658","4.3091",106140000,3,"0.423233",1,"-6.304","-0.991954","sp|Q9UHA3|RLP24_HUMAN;tr|H3BMQ2|H3BMQ2_HUMAN","sp|Q9UHA3|RLP24_HUMAN;tr|H3BMQ2|H3BMQ2_HUMAN",5014,"Q9UHA3","RLP24_HUMAN","Probable ribosome biogenesis protein RLP24",null,"RSL24D1"]
[1,"17.1752",1,"20.3853","16.7024",1,{"$nulls":3},"positive regulation of neuron projection development",{"$nulls":5},2,2,2,"42.5","42.5","42.5","8.7247","0.00042626","4.8054",23704000,2,"0.322355",1,"-6.30416","-0.78557","tr|K7ENZ6|K7ENZ6_HUMAN;tr|K7EMF4|K7EMF4_HUMAN;tr|K7ELM8|K7ELM8_HUMAN;tr|K7EJ34|K7EJ34_HUMAN;tr|K7ENF4|K7ENF4_HUMAN;sp|Q86VR2|F134C_HUMAN","tr|K7ENZ6|K7ENZ6_HUMAN;tr|K7EMF4|K7EMF4_HUMAN;tr|K7ELM8|K7ELM8_HUMAN;tr|K7EJ34|K7EJ34_HUMAN;tr|K7ENF4|K7ENF4_HUMAN;sp|Q86VR2|F134C_HUMAN",3235,"K7ENZ6","K7ENZ6_HUMAN",null,null,"RETREG3"]
[1,"21.1664","20.9876","21.8677","19.4928","20.7076",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"41.3","41.3","41.3","7.2634",0,"8.6394",51627000,10,"0.396053",1,"-6.30468","-0.937142","tr|Q9HB66|Q9HB66_HUMAN","tr|Q9HB66|Q9HB66_HUMAN",5619,"Q9HB66","Q9HB66_HUMAN"]
[1,1,"18.8676","19.9587",1,"18.921",{"$nulls":5},"cytoplasm",{"$nulls":3},2,2,2,"31.2","31.2","31.2","11.25",0,"7.4653",20376000,7,"0.300699",1,"-6.33737","-0.739997","tr|L0R819|L0R819_HUMAN;tr|U3KQE3|U3KQE3_HUMAN;tr|U3KQP6|U3KQP6_HUMAN;tr|U3KQ49|U3KQ49_HUMAN;tr|U3KQP1|U3KQP1_HUMAN","tr|L0R819|L0R819_HUMAN;tr|U3KQE3|U3KQE3_HUMAN;tr|U3KQP6|U3KQP6_HUMAN;tr|U3KQ49|U3KQ49_HUMAN;tr|U3KQP1|U3KQP1_HUMAN",5599,"L0R819","ASURF_HUMAN","ASNSD1 upstream open reading frame protein {ECO:0000312|HGNC:HGNC:53619}",null,"ASDURF"]
[1,"18.4194","19.2986","19.7916","18.6429","19.3079",{"$nulls":3},"DNA strand elongation involved in DNA replication;DNA strand elongation involved in mitotic DNA replication;inner cell mass cell proliferation","3'-5' DNA helicase activity","cytoplasm;GINS complex;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"7.1","7.1","7.1","22.988",0,"16.375",60218000,10,"0.458612",1,"-6.34146","-1.06263","sp|Q14691|PSF1_HUMAN","sp|Q14691|PSF1_HUMAN",2497,"Q14691","PSF1_HUMAN","DNA replication complex GINS protein PSF1",null,"GINS1"]
[1,"16.0997","16.4574","17.8207","17.6749","17.1264",{"$nulls":3},"nucleocytoplasmic transport",null,"nuclear pore",{"$nulls":3},4,4,4,"8.9","8.9","8.9","49.095",0,"6.3609",34536000,3,"0.551922",1,"-6.35498","-1.2465","tr|Q5JRG1|Q5JRG1_HUMAN;tr|H7BYF2|H7BYF2_HUMAN;sp|Q9BVL2|NUPL1_HUMAN","tr|Q5JRG1|Q5JRG1_HUMAN;tr|H7BYF2|H7BYF2_HUMAN;sp|Q9BVL2|NUPL1_HUMAN",4256,"Q5JRG1","Q5JRG1_HUMAN",null,null,"NUP58"]
[1,1,"13.2889","20.3744",1,"12.9938",{"$nulls":3},"activation of MAPKK activity;cellular response to nerve growth factor stimulus;dendrite morphogenesis;in utero embryonic development;nerve growth factor signaling pathway;positive regulation of neuron projection development;regulation of protein kinase activity","PDZ domain binding;protein kinase regulator activity","cytosol;integral component of membrane;late endosome;membrane;protein complex","Neurotrophin signaling pathway",null,null,5,5,5,"4.5","4.5","4.5","196.54",0,"15.662",154520000,10,"0.383566",1,"-6.35977","-0.911788","sp|Q9ULH0|KDIS_HUMAN;tr|E9PH70|E9PH70_HUMAN;tr|H0Y8E4|H0Y8E4_HUMAN;tr|F8WAY8|F8WAY8_HUMAN","sp|Q9ULH0|KDIS_HUMAN;tr|E9PH70|E9PH70_HUMAN;tr|H0Y8E4|H0Y8E4_HUMAN",5121,"Q9ULH0","KDIS_HUMAN","Kinase D-interacting substrate of 220 kDa",null,"KIDINS220"]
[1,1,"20.8175","20.3712",1,"20.5752",{"$nulls":4},"calcium ion binding;mannosyl-oligosaccharide 1,2-alpha-mannosidase activity","membrane",{"$nulls":3},1,1,1,"23.7","23.7","23.7","11.167","0.003937","2.6385",16527000,1,"0.276544",1,"-6.37634","-0.688482","tr|Q5T9E3|Q5T9E3_HUMAN;tr|H0Y543|H0Y543_HUMAN;sp|O60476|MA1A2_HUMAN","tr|Q5T9E3|Q5T9E3_HUMAN;tr|H0Y543|H0Y543_HUMAN;sp|O60476|MA1A2_HUMAN",495,"Q5T9E3","Q5T9E3_HUMAN",null,null,"MAN1A2"]
[1,"22.5295","22.2765","19.7572","22.8506","22.348",{"$nulls":3},"nervous system development",null,"integral component of membrane",{"$nulls":3},2,2,2,"8.9","8.9","8.9","32.513",0,"24.219",431460000,14,"0.371278",1,"-6.3833","-0.886719","sp|Q5BJD5|TM41B_HUMAN;tr|E9PJ42|E9PJ42_HUMAN","sp|Q5BJD5|TM41B_HUMAN;tr|E9PJ42|E9PJ42_HUMAN",2800,"Q5BJD5","TM41B_HUMAN","Transmembrane protein 41B",null,"TMEM41B"]
["19.6447",1,"19.4788","21.9581","17.7296","19.6266",{"$nulls":3},"neutrophil degranulation;ossification;signal transduction","SH3 domain binding","extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular;secretory granule lumen",{"$nulls":3},2,2,2,"17.3","17.3","17.3","23.787",0,"9.5985",86657000,5,"0.434355",1,"-6.39695","-1.01425","sp|Q92882|OSTF1_HUMAN","sp|Q92882|OSTF1_HUMAN",3729,"Q92882","OSTF1_HUMAN","Osteoclast-stimulating factor 1",null,"OSTF1"]
["18.5598","17.4969",1,"19.3166","17.6802","19.2551",{"$nulls":3},"apoptotic process;centrosome cycle;microtubule cytoskeleton organization;mitochondrion transport along microtubule;negative regulation of G0 to G1 transition;negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","beta-tubulin binding;chromatin binding;microtubule binding;RNA polymerase II transcription corepressor activity","centrosome;cytoplasm;cytoskeleton;nucleoplasm;nucleus;spindle pole",{"$nulls":3},2,2,2,"15.3","15.3","15.3","18.246","0.00042391","4.6716",27437000,2,"0.487882",1,"-6.39839","-1.12064","sp|Q9UBK9|UXT_HUMAN;tr|A0A0C4DFR8|A0A0C4DFR8_HUMAN;tr|S4R2Z4|S4R2Z4_HUMAN","sp|Q9UBK9|UXT_HUMAN;tr|A0A0C4DFR8|A0A0C4DFR8_HUMAN;tr|S4R2Z4|S4R2Z4_HUMAN",4959,"Q9UBK9","UXT_HUMAN","Protein UXT",null,"UXT"]
["19.3097",1,1,"19.5672",1,"20.0568",{"$nulls":3},"embryonic morphogenesis;tRNA splicing, via endonucleolytic cleavage and ligation",null,"nucleoplasm;tRNA-splicing ligase complex",{"$nulls":3},2,2,2,"16.8","16.8","16.8","25.858",0,"5.4005",47915000,4,"0.298645",1,"-6.43809","-0.735645","sp|Q9BVC5|ASHWN_HUMAN;tr|C9J4K0|C9J4K0_HUMAN","sp|Q9BVC5|ASHWN_HUMAN;tr|C9J4K0|C9J4K0_HUMAN",4247,"Q9BVC5","ASHWN_HUMAN","Ashwin",null,"C2orf49"]
[1,"15.8561","16.3895","18.4445","16.4388","17.6943",{"$nulls":3},"amyloid-beta clearance;cellular response to fatty acid;cellular response to low-density lipoprotein particle stimulus;cholesterol homeostasis;cholesterol import;cholesterol metabolic process;cholesterol transport;chylomicron remnant clearance;endocytosis;intestinal cholesterol absorption;lipid metabolic process;lipoprotein catabolic process;long-term memory;low-density lipoprotein particle clearance;membrane organization;negative regulation of amyloid fibril formation;negative regulation of astrocyte activation;negative regulation of gene expression;negative regulation of microglial cell activation;negative regulation of protein metabolic process;phospholipid transport;plasma lipoprotein particle clearance;positive regulation of amyloid-beta clearance;positive regulation of endocytosis;positive regulation of gene expression;positive regulation of inflammatory response;positive regulation of lipoprotein particle clearance;positive regulation of lysosomal protein catabolic process;positive regulation of triglyceride biosynthetic process;receptor-mediated endocytosis;receptor-mediated endocytosis involved in cholesterol transport;regulation of cholesterol homeostasis;regulation of cholesterol metabolic process;regulation of phosphatidylcholine catabolic process;regulation of protein metabolic process;response to caloric restriction","amyloid-beta binding;calcium ion binding;clathrin heavy chain binding;identical protein binding;low-density lipoprotein particle binding;low-density lipoprotein receptor activity;protease binding;very-low-density lipoprotein particle receptor activity;virus receptor activity","apical part of cell;basolateral plasma membrane;cell surface;clathrin-coated endocytic vesicle membrane;clathrin-coated pit;early endosome;endolysosome membrane;endosome membrane;external side of plasma membrane;Golgi apparatus;integral component of plasma membrane;intracellular;late endosome;low-density lipoprotein particle;lysosome;membrane;PCSK9-LDLR complex;plasma membrane;receptor complex;somatodendritic compartment;sorting endosome","Aldosterone synthesis and secretion;Bile secretion;Cholesterol metabolism;Cortisol synthesis and secretion;Cushing syndrome;Endocytosis;Hepatitis C;Ovarian steroidogenesis;Toxoplasmosis",null,null,2,2,2,"3.1","3.1","3.1","95.375",0,"6.7764",53732000,5,"0.563544",1,"-6.44399","-1.26923","sp|P01130|LDLR_HUMAN;tr|J3KMZ9|J3KMZ9_HUMAN;tr|H0YM92|H0YM92_HUMAN;tr|H0YMD1|H0YMD1_HUMAN","sp|P01130|LDLR_HUMAN;tr|J3KMZ9|J3KMZ9_HUMAN;tr|H0YM92|H0YM92_HUMAN;tr|H0YMD1|H0YMD1_HUMAN",843,"P01130","LDLR_HUMAN","Low-density lipoprotein receptor","DL receptor","LDLR"]
[1,"14.2542",1,"19.5121","15.0921",1,{"$nulls":3},"astrocyte fate commitment;branching involved in ureteric bud morphogenesis;bronchus cartilage development;cAMP-mediated signaling;cartilage condensation;cartilage development;cell fate specification;cell-cell adhesion;cellular response to BMP stimulus;cellular response to epidermal growth factor stimulus;cellular response to heparin;cellular response to interleukin-1;cellular response to mechanical stimulus;cellular response to retinoic acid;cellular response to transforming growth factor beta stimulus;chondrocyte differentiation;chondrocyte differentiation involved in endochondral bone morphogenesis;chondrocyte hypertrophy;chromatin remodeling;cochlea morphogenesis;cytoskeleton organization;endocardial cushion morphogenesis;endocrine pancreas development;epidermal growth factor receptor signaling pathway;epithelial cell proliferation involved in prostatic bud elongation;epithelial to mesenchymal transition;epithelial tube branching involved in lung morphogenesis;ERK1 and ERK2 cascade;extracellular matrix organization;hair follicle development;Harderian gland development;heart valve development;heart valve formation;heart valve morphogenesis;intestinal epithelial structure maintenance;intrahepatic bile duct development;lacrimal gland development;limb bud formation;lung epithelial cell differentiation;lung smooth muscle development;male germ-line sex determination;male gonad development;mammary gland development;metanephric nephron tubule formation;morphogenesis of a branching epithelium;negative regulation of apoptotic process;negative regulation of biomineral tissue development;negative regulation of bone mineralization;negative regulation of canonical Wnt signaling pathway;negative regulation of chondrocyte differentiation;negative regulation of epithelial cell differentiation;negative regulation of epithelial cell proliferation;negative regulation of immune system process;negative regulation of mesenchymal cell apoptotic process;negative regulation of myoblast differentiation;negative regulation of ossification;negative regulation of photoreceptor cell differentiation;negative regulation of pri-miRNA transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;neural crest cell development;neural crest cell fate specification;Notch signaling pathway;notochord development;nucleosome assembly;oligodendrocyte differentiation;ossification;otic vesicle formation;positive regulation of branching involved in ureteric bud morphogenesis;positive regulation of cartilage development;positive regulation of cell proliferation;positive regulation of cell proliferation involved in heart morphogenesis;positive regulation of chondrocyte differentiation;positive regulation of epithelial cell differentiation;positive regulation of epithelial cell migration;positive regulation of epithelial cell proliferation;positive regulation of extracellular matrix assembly;positive regulation of kidney development;positive regulation of male gonad development;positive regulation of mesenchymal cell proliferation;positive regulation of mesenchymal stem cell differentiation;positive regulation of phosphatidylinositol 3-kinase signaling;positive regulation of protein catabolic process;positive regulation of protein phosphorylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;prostate gland development;protein complex assembly;protein kinase B signaling;protein localization to nucleus;regulation of apoptotic process;regulation of branching involved in lung morphogenesis;regulation of cell adhesion;regulation of cell cycle process;regulation of cell proliferation;regulation of cell proliferation involved in tissue homeostasis;regulation of epithelial cell proliferation involved in lung morphogenesis;renal vesicle induction;retina development in camera-type eye;retinal rod cell differentiation;Sertoli cell development;Sertoli cell differentiation;signal transduction;skeletal system development;somatic stem cell population maintenance;spermatogenesis;tissue homeostasis;trachea cartilage development;transcription initiation from RNA polymerase II promoter;ureter morphogenesis;ureter smooth muscle cell differentiation;ureter urothelium development","beta-catenin binding;bHLH transcription factor binding;chromatin binding;core promoter sequence-specific DNA binding;DNA binding transcription factor activity;enhancer binding;enhancer sequence-specific DNA binding;pre-mRNA intronic binding;protein heterodimerization activity;protein kinase A catalytic subunit binding;protein kinase activity;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nuclear transcription factor complex;nucleoplasm;nucleus;protein complex","cAMP signaling pathway",null,null,2,2,2,"6.7","6.7","6.7","56.136",0,"18.617",20269000,4,"0.380753",1,"-6.44997","-0.906059","sp|P48436|SOX9_HUMAN","sp|P48436|SOX9_HUMAN",1626,"P48436","SOX9_HUMAN","Transcription factor SOX-9 {ECO:0000305}",null,"SOX9"]
["15.7561","18.9727",1,"17.3926","18.6567","19.0362",{"$nulls":3},"apoptotic process;lipid transport;phagocytosis, engulfment","signal transducer activity","cytoplasm",{"$nulls":3},10,10,10,"36.5","36.5","36.5","34.49",0,"86.375",688240000,33,"0.508554",1,"-6.45221","-1.1614","sp|Q9UBP9|GULP1_HUMAN;tr|H0Y6R1|H0Y6R1_HUMAN;tr|H7BZV7|H7BZV7_HUMAN;tr|B8ZZL1|B8ZZL1_HUMAN","sp|Q9UBP9|GULP1_HUMAN",4966,"Q9UBP9","GULP1_HUMAN","PTB domain-containing engulfment adapter protein 1",null,"GULP1"]
["16.8639",1,"18.2996","19.0827","17.7427","18.7474",{"$nulls":3},"granulocyte differentiation;hematopoietic stem cell proliferation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;Notch signaling pathway;positive regulation of alpha-beta T cell differentiation;positive regulation of protein targeting to mitochondrion;stem cell population maintenance;T cell differentiation in thymus;transcription, DNA-templated","chromatin binding;chromatin DNA binding;RNA binding","cytosol;nucleoplasm",{"$nulls":3},4,4,4,"13.3","13.3","13.3","47.138",0,"11.541",157320000,13,"0.509965",1,"-6.46978","-1.16418","sp|Q8N5F7|NKAP_HUMAN;sp|Q5M9Q1|NKAPL_HUMAN","sp|Q8N5F7|NKAP_HUMAN;sp|Q5M9Q1|NKAPL_HUMAN",3413,"Q8N5F7","NKAP_HUMAN","NF-kappa-B-activating protein",null,"NKAP"]
["16.9165",1,"16.1302","18.0546","17.7423","17.878",{"$nulls":3},"porphyrin-containing compound biosynthetic process","4 iron, 4 sulfur cluster binding;coproporphyrinogen oxidase activity;metal ion binding","mitochondrion",{"$nulls":3},5,5,5,"12.2","12.2","12.2","48.713",0,"10.683",50827000,7,"0.560368",1,"-6.54271","-1.26302","sp|Q9HA92|RSAD1_HUMAN;tr|H0Y9X4|H0Y9X4_HUMAN","sp|Q9HA92|RSAD1_HUMAN",4555,"Q9HA92","RSAD1_HUMAN","Radical S-adenosyl methionine domain-containing protein 1, mitochondrial",null,"RSAD1"]
["14.8727","13.0137",1,"17.5063","13.0293","18.0878",{"$nulls":3},"Golgi to plasma membrane transport;neutrophil degranulation;protein transport",null,"early endosome;ficolin-1-rich granule membrane;integral component of membrane;plasma membrane",{"$nulls":3},5,5,5,"6.9","6.9","6.9","109.56",0,"9.0941",33375000,5,"0.641032",1,"-6.57901","-1.42032","sp|Q7Z3J2|CP062_HUMAN;tr|E7EWW0|E7EWW0_HUMAN;tr|H3BVG8|H3BVG8_HUMAN;tr|F5H7K1|F5H7K1_HUMAN;tr|C9J7I2|C9J7I2_HUMAN;tr|H3BNX2|H3BNX2_HUMAN;tr|F6S1J4|F6S1J4_HUMAN;tr|H3BV68|H3BV68_HUMAN;tr|H0YFG6|H0YFG6_HUMAN;tr|H3BTI5|H3BTI5_HUMAN;tr|I3L1U5|I3L1U5_HUMAN","sp|Q7Z3J2|CP062_HUMAN;tr|E7EWW0|E7EWW0_HUMAN;tr|H3BVG8|H3BVG8_HUMAN;tr|F5H7K1|F5H7K1_HUMAN;tr|C9J7I2|C9J7I2_HUMAN",3155,"Q7Z3J2","CP062_HUMAN","UPF0505 protein C16orf62",null,"C16orf62"]
["17.4036","15.017",1,"18.3216","17.1903","17.6814",{"$nulls":3},"cell differentiation;multicellular organism development;negative regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;histone acetyltransferase binding;metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nucleus",{"$nulls":3},4,4,4,"14.4","14.4","14.4","61.438",0,"86.701",112390000,15,"0.571864",1,"-6.59088","-1.28548","sp|O95365|ZBT7A_HUMAN","sp|O95365|ZBT7A_HUMAN",746,"O95365","ZBT7A_HUMAN","Zinc finger and BTB domain-containing protein 7A",null,"ZBTB7A"]
["21.0053",1,1,"20.7819",1,"21.1099",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"17.1","17.1","17.1","8.6961",0,"13.514",120850000,9,"0.283743",1,"-6.62883","-0.703916","sp|Q8WVI0|SMIM4_HUMAN","sp|Q8WVI0|SMIM4_HUMAN",3619,"Q8WVI0","SMIM4_HUMAN","Small integral membrane protein 4",null,"SMIM4"]
[1,1,"19.6615","20.561",1,"20.0511",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;cellular response to glucagon stimulus;high-density lipoprotein particle assembly;male gonad development;renal water homeostasis;spermatogenesis;stimulatory C-type lectin receptor signaling pathway","ATP binding;cAMP-dependent protein kinase activity;protein serine/threonine kinase activity","ciliary base;cytosol;intercellular bridge;nucleoplasm","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Amoebiasis;Amphetamine addiction;Apelin signaling pathway;Autophagy - animal;Bile secretion;Calcium signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cortisol synthesis and secretion;Cushing syndrome;Dilated cardiomyopathy (DCM);Dopaminergic synapse;Endocrine and other factor-regulated calcium reabsorption;Endocrine resistance;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Hedgehog signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Inflammatory mediator regulation of TRP channels;Insulin secretion;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Morphine addiction;Olfactory transduction;Oocyte meiosis;Ovarian steroidogenesis;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Platelet activation;Prion diseases;Progesterone-mediated oocyte maturation;Proteoglycans in cancer;Ras signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Taste transduction;Thermogenesis;Thyroid hormone signaling pathway;Thyroid hormone synthesis;Tight junction;Vascular smooth muscle contraction;Vasopressin-regulated water reabsorption;Vibrio cholerae infection;Viral carcinogenesis;Wnt signaling pathway",null,null,2,1,1,"9.4","6.8","6.8","40.434",0,"43.394",64604000,3,"0.302076",1,"-6.65021","-0.742911","sp|P22612|KAPCG_HUMAN","sp|P22612|KAPCG_HUMAN",1247,"P22612","KAPCG_HUMAN","cAMP-dependent protein kinase catalytic subunit gamma","KA C-gamma","PRKACG"]
["21.8419",1,"21.9746","21.3763","21.4574","21.959",{"$nulls":4},"translation elongation factor activity","eukaryotic translation elongation factor 1 complex",{"$nulls":3},9,1,1,62,"11.2","11.2","20.819",0,"23.552",252210000,10,"0.404923",1,"-6.65875","-0.955084","tr|E9PL71|E9PL71_HUMAN;tr|E9PN91|E9PN91_HUMAN;tr|E9PKK3|E9PKK3_HUMAN;tr|E9PNW6|E9PNW6_HUMAN;tr|E9PJD0|E9PJD0_HUMAN","tr|E9PL71|E9PL71_HUMAN;tr|E9PN91|E9PN91_HUMAN",5518,"E9PL71","E9PL71_HUMAN",null,null,"EEF1D"]
["20.6697",1,"20.7974","21.0566","20.3926","21.0265",{"$nulls":3},"vacuolar transport",null,"cytosol",{"$nulls":3},2,2,2,"10.9","10.9","10.9","20.772",0,"6.7483",108240000,8,"0.433919",1,"-6.66953","-1.01337","tr|C9J0A7|C9J0A7_HUMAN;sp|Q9UQN3|CHM2B_HUMAN;tr|A0A087WW88|A0A087WW88_HUMAN","tr|C9J0A7|C9J0A7_HUMAN;sp|Q9UQN3|CHM2B_HUMAN;tr|A0A087WW88|A0A087WW88_HUMAN",5192,"C9J0A7","C9J0A7_HUMAN",null,null,"CHMP2B"]
["15.7508","14.8936",1,"18.6993","15.924","17.0746",{"$nulls":3},"cell division;centrosome cycle;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;regulation of G2/M transition of mitotic cell cycle;spindle assembly",null,"centrosome;cytosol;HAUS complex;microtubule;spindle",{"$nulls":3},4,4,4,"7.9","7.9","7.9","71.682",0,"8.0568",52406000,1,"0.619754",1,"-6.68451","-1.37888","sp|O94927|HAUS5_HUMAN;tr|K7EQ61|K7EQ61_HUMAN","sp|O94927|HAUS5_HUMAN",697,"O94927","HAUS5_HUMAN","HAUS augmin-like complex subunit 5",null,"HAUS5"]
[1,"18.0745","21.3698","20.2603","19.5291","20.8239",{"$nulls":3},"branched-chain amino acid catabolic process;fatty acid beta-oxidation using acyl-CoA dehydrogenase;leucine catabolic process","flavin adenine dinucleotide binding;isovaleryl-CoA dehydrogenase activity","mitochondrial matrix","Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,8,8,8,21,21,21,"46.319",0,"20.839",219640000,22,"0.458851",1,"-6.723","-1.06311","sp|P26440|IVD_HUMAN;tr|A0A0A0MT83|A0A0A0MT83_HUMAN;tr|H0YLC3|H0YLC3_HUMAN;tr|H7C4G6|H7C4G6_HUMAN;tr|H0YKV0|H0YKV0_HUMAN;tr|H0YN10|H0YN10_HUMAN;tr|A0A087WVD3|A0A087WVD3_HUMAN","sp|P26440|IVD_HUMAN;tr|A0A0A0MT83|A0A0A0MT83_HUMAN;tr|H0YLC3|H0YLC3_HUMAN;tr|H7C4G6|H7C4G6_HUMAN",1307,"P26440","IVD_HUMAN","Isovaleryl-CoA dehydrogenase, mitochondrial","VD","IVD"]
[1,"18.1196","16.1696","19.8011","17.7027","18.0561",{"$nulls":3},"nuclear import;spliceosomal snRNP assembly",null,"cytoplasm;cytosol;Gemini of coiled bodies;nucleoplasm;nucleus;SMN complex;SMN-Sm protein complex","RNA transport",null,null,5,5,5,"17.8","17.8","17.8","28.636",0,"38.581",374680000,16,"0.548545",1,"-6.75693","-1.23989","sp|Q9NWZ8|GEMI8_HUMAN;tr|H7BYE2|H7BYE2_HUMAN","sp|Q9NWZ8|GEMI8_HUMAN",4804,"Q9NWZ8","GEMI8_HUMAN","Gem-associated protein 8","emin-8","GEMIN8"]
[1,1,"20.4116","21.0605",1,"20.6285",{"$nulls":9},1,1,1,"25.7","25.7","25.7","7.6915",0,"10.47",41216000,7,"0.296167",1,"-6.75912","-0.730388","tr|F5H3X1|F5H3X1_HUMAN;tr|F5H052|F5H052_HUMAN;tr|F5H2X2|F5H2X2_HUMAN;tr|F5H2K4|F5H2K4_HUMAN;tr|F5GWV0|F5GWV0_HUMAN;tr|F5H4P3|F5H4P3_HUMAN;sp|Q6NXE6|ARMC6_HUMAN","tr|F5H3X1|F5H3X1_HUMAN;tr|F5H052|F5H052_HUMAN;tr|F5H2X2|F5H2X2_HUMAN;tr|F5H2K4|F5H2K4_HUMAN;tr|F5GWV0|F5GWV0_HUMAN;tr|F5H4P3|F5H4P3_HUMAN;sp|Q6NXE6|ARMC6_HUMAN",2986,"F5H3X1","F5H3X1_HUMAN",null,null,"ARMC6"]
[1,"17.894","20.3602","21.0128","18.1978","20.3491",{"$nulls":3},"cell division;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;sister chromatid cohesion;tRNA export from nucleus;viral process;viral transcription",null,"condensed chromosome kinetochore;cytosol;host cell;nuclear envelope;nuclear pore outer ring","RNA transport",null,null,3,3,3,"11.3","11.3","11.3","42.15",0,"21.879",98896000,4,"0.478346",1,"-6.76846","-1.10178","sp|Q8NFH3|NUP43_HUMAN","sp|Q8NFH3|NUP43_HUMAN",3505,"Q8NFH3","NUP43_HUMAN","Nucleoporin Nup43",null,"NUP43"]
["16.9909","19.651",1,"22.8471","19.179","15.9615",{"$nulls":9},2,2,2,"2.4","2.4","2.4","99.165","0.0048507","2.5472",955570000,4,"0.478403",1,"-6.7819","-1.10189","tr|K7EPA2|K7EPA2_HUMAN;tr|H0Y966|H0Y966_HUMAN;sp|Q8TEP8|CE192_HUMAN;tr|A0A0A0MR42|A0A0A0MR42_HUMAN;tr|K7ENP4|K7ENP4_HUMAN;tr|C9JT09|C9JT09_HUMAN","tr|K7EPA2|K7EPA2_HUMAN;tr|H0Y966|H0Y966_HUMAN;sp|Q8TEP8|CE192_HUMAN;tr|A0A0A0MR42|A0A0A0MR42_HUMAN;tr|K7ENP4|K7ENP4_HUMAN;tr|C9JT09|C9JT09_HUMAN",3579,"K7EPA2","K7EPA2_HUMAN",null,null,"CEP192"]
[1,"17.1732","17.6582","19.487","17.9664","18.8406",{"$nulls":3},"cholesterol biosynthetic process;isopentenyl diphosphate biosynthetic process, mevalonate pathway","ATP binding;mevalonate kinase activity","cytoplasm",{"$nulls":3},2,2,2,7,7,7,"37.171",0,"9.4489",52706000,3,"0.549676",1,"-6.82088","-1.2421","tr|F5H8H2|F5H8H2_HUMAN;sp|Q03426|KIME_HUMAN;tr|A0A0B4J236|A0A0B4J236_HUMAN","tr|F5H8H2|F5H8H2_HUMAN;sp|Q03426|KIME_HUMAN;tr|A0A0B4J236|A0A0B4J236_HUMAN",2177,"F5H8H2","F5H8H2_HUMAN","Mevalonate kinase {ECO:0000256|RuleBase:RU363087}","K {ECO:0000256|RuleBase:RU363087}"]
[1,"16.7676","16.4643","18.9699","17.4201","18.329",{"$nulls":3},"depyrimidination;nucleotide-excision repair","class I DNA-(apurinic or apyrimidinic site) lyase activity;class III/IV DNA-(apurinic or apyrimidinic site) lyase activity;damaged DNA binding;DNA N-glycosylase activity;microtubule binding;zinc ion binding","cytoplasm;nucleolus;nucleoplasm;nucleus;spindle microtubule","Base excision repair",null,null,7,7,7,31,31,31,"36.826",0,"20.367",162530000,33,"0.58283",1,"-6.82907","-1.30689","sp|Q969S2|NEIL2_HUMAN","sp|Q969S2|NEIL2_HUMAN",3765,"Q969S2","NEIL2_HUMAN","Endonuclease 8-like 2",null,"NEIL2"]
[1,"14.3647","18.4706","17.6619","17.7892","18.9488",{"$nulls":3},"RNA secondary structure unwinding;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;nucleolus;nucleoplasm",{"$nulls":3},12,12,12,"35.2","35.2","35.2","54.226",0,"89.985",462860000,52,"0.577152",1,"-6.85484","-1.29581","sp|Q9Y6V7|DDX49_HUMAN;tr|M0R1S3|M0R1S3_HUMAN;tr|M0QZC0|M0QZC0_HUMAN;tr|M0R0K1|M0R0K1_HUMAN","sp|Q9Y6V7|DDX49_HUMAN",5423,"Q9Y6V7","DDX49_HUMAN","Probable ATP-dependent RNA helicase DDX49",null,"DDX49"]
[1,"19.3246",1,"21.639","19.3453",1,{"$nulls":3},"associative learning;nervous system development;positive regulation of long-term synaptic potentiation;signal transduction;telencephalon development","calmodulin binding;phosphatidic acid binding;phosphatidylinositol-3,4,5-trisphosphate binding","axon;dendritic spine head;mitochondrial membrane;neuronal cell body;nucleus;postsynaptic density;trans-Golgi network transport vesicle membrane",{"$nulls":3},1,1,1,"17.9","17.9","17.9","7.6184","0.0019312","3.0903",24791000,1,"0.31498",1,"-6.88655","-0.77011","sp|Q92686|NEUG_HUMAN","sp|Q92686|NEUG_HUMAN",3702,"Q92686","NEUG_HUMAN","Neurogranin","g","NRGN"]
["21.6949",1,1,"22.2268",1,"21.28",{"$nulls":3},"cholesterol biosynthetic process;fatty acid metabolic process;steroid metabolic process;sterol biosynthetic process","C-4 methylsterol oxidase activity;iron ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;plasma membrane","Metabolic pathways;Steroid biosynthesis",null,null,2,2,2,"8.9","8.9","8.9","35.215",0,"23.771",125350000,11,"0.286506",1,"-6.93728","-0.70982","sp|Q15800|MSMO1_HUMAN;tr|D6REA2|D6REA2_HUMAN;tr|D6RDP9|D6RDP9_HUMAN;tr|D6R952|D6R952_HUMAN","sp|Q15800|MSMO1_HUMAN;tr|D6REA2|D6REA2_HUMAN;tr|D6RDP9|D6RDP9_HUMAN;tr|D6R952|D6R952_HUMAN",2644,"Q15800","MSMO1_HUMAN","Methylsterol monooxygenase 1",null,"MSMO1"]
[1,"16.3979","18.2205","19.4334","18.4779","18.5333",{"$nulls":4},"mRNA binding","cytosol;nucleolus;nucleus",{"$nulls":3},3,3,3,"17.3","17.3","17.3","26.071","0.00042772","4.8913",28741000,2,"0.56342",1,"-6.94207","-1.26898","tr|H0YAE8|H0YAE8_HUMAN;tr|E7EUV9|E7EUV9_HUMAN;sp|Q14493|SLBP_HUMAN;tr|F8W8D3|F8W8D3_HUMAN;tr|H7C4H8|H7C4H8_HUMAN","tr|H0YAE8|H0YAE8_HUMAN;tr|E7EUV9|E7EUV9_HUMAN;sp|Q14493|SLBP_HUMAN;tr|F8W8D3|F8W8D3_HUMAN;tr|H7C4H8|H7C4H8_HUMAN",2475,"H0YAE8","H0YAE8_HUMAN",null,null,"SLBP"]
["21.9557",1,"20.8598","22.8871","20.5876","21.2399",{"$nulls":3},"cell cycle;cell division","cyclin-dependent protein serine/threonine kinase regulator activity",{"$nulls":4},3,3,3,"38.8","38.8","38.8","8.027",0,"9.9229",83872000,9,"0.436152",1,"-6.96634","-1.01784","tr|Q5T179|Q5T179_HUMAN;sp|P61024|CKS1_HUMAN;tr|Q9BZU3|Q9BZU3_HUMAN","tr|Q5T179|Q5T179_HUMAN;sp|P61024|CKS1_HUMAN",1912,"Q5T179","Q5T179_HUMAN","Cyclin-dependent kinases regulatory subunit {ECO:0000256|RuleBase:RU311113}",null,"CKS1B"]
[1,"22.2453","19.0909","20.45","21.6465","21.3201",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,3,3,3,"19.3","19.3","19.3","18.546",0,"7.7335",235240000,10,"0.457328",1,"-7.02682","-1.06008","sp|Q8TCC3|RM30_HUMAN;tr|B8ZZV5|B8ZZV5_HUMAN","sp|Q8TCC3|RM30_HUMAN",3550,"Q8TCC3","RM30_HUMAN","39S ribosomal protein L30, mitochondrial","30mt;RP-L30","MRPL30"]
["19.9064",1,"20.9604","21.2489","20.8157","20.9664",{"$nulls":9},4,4,4,"27.5","27.5","27.5","20.012",0,"6.4875",73912000,7,"0.471218",1,"-7.05476","-1.08766","sp|Q8N5M4|TTC9C_HUMAN;tr|H0YDR3|H0YDR3_HUMAN;tr|E9PKV8|E9PKV8_HUMAN;tr|E7EST3|E7EST3_HUMAN","sp|Q8N5M4|TTC9C_HUMAN;tr|H0YDR3|H0YDR3_HUMAN;tr|E9PKV8|E9PKV8_HUMAN",3418,"Q8N5M4","TTC9C_HUMAN","Tetratricopeptide repeat protein 9C","PR repeat protein 9C","TTC9C"]
["23.9044","22.6558",1,"24.1379","21.6773","22.9438",{"$nulls":9},2,2,1,"87.8","87.8","68.3","3.9694",0,"16.872",114820000,7,"0.400449",1,"-7.06627","-0.946042","tr|K7ENI6|K7ENI6_HUMAN;tr|K7ERE1|K7ERE1_HUMAN;sp|Q8N2U0|TM256_HUMAN","tr|K7ENI6|K7ENI6_HUMAN;tr|K7ERE1|K7ERE1_HUMAN;sp|Q8N2U0|TM256_HUMAN",3384,"K7ENI6","K7ENI6_HUMAN",null,null,"TMEM256-PLSCR3"]
[1,"14.519","16.4423","18.4894","16.463","18.2932",{"$nulls":3},"cell proliferation;mitotic chromosome movement towards spindle pole;positive regulation of mitotic metaphase/anaphase transition;protein complex assembly;signaling","phosphoprotein phosphatase activity","cytosol;microtubule organizing center;mitochondrion;nucleus;spindle pole centrosome",{"$nulls":3},4,4,4,"6.7","6.7","6.7","95.114",0,"9.7581",49818000,8,"0.65499",1,"-7.09476","-1.4475","sp|Q15398|DLGP5_HUMAN;tr|G3V4E5|G3V4E5_HUMAN","sp|Q15398|DLGP5_HUMAN",2596,"Q15398","DLGP5_HUMAN","Disks large-associated protein 5","AP-5","DLGAP5"]
[1,"16.4243","22.1189","18.607","20.6978","21.6536",{"$nulls":3},"DNA replication","DNA binding","fibrillar center;nuclear origin of replication recognition complex;nucleus",{"$nulls":3},3,3,3,"17.2","17.2","17.2","22.791","0.0004152","4.2273",200380000,1,"0.487674",1,"-7.13841","-1.12023","tr|H3BT22|H3BT22_HUMAN;sp|Q9Y5N6|ORC6_HUMAN","tr|H3BT22|H3BT22_HUMAN;sp|Q9Y5N6|ORC6_HUMAN",5360,"H3BT22","H3BT22_HUMAN",null,null,"ORC6"]
[1,"18.1386","18.027","20.3927","17.993","20.3123",{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,"19.4","19.4","19.4","20.252","0.0091241","2.2337",35733000,1,"0.552988",1,"-7.17744","-1.24858","tr|A0A0G2JSB3|A0A0G2JSB3_HUMAN;tr|I3L1D4|I3L1D4_HUMAN;tr|B0QYY7|B0QYY7_HUMAN;tr|S4R469|S4R469_HUMAN;tr|F8VR27|F8VR27_HUMAN;tr|F8VZY7|F8VZY7_HUMAN;tr|B0QYV1|B0QYV1_HUMAN;tr|B0QYY4|B0QYY4_HUMAN;tr|A0A087X2B1|A0A087X2B1_HUMAN;tr|A0A0G2JRA5|A0A0G2JRA5_HUMAN;sp|O43251|RFOX2_HUMAN;sp|Q9NWB1|RFOX1_HUMAN;tr|J3KNW3|J3KNW3_HUMAN;tr|B7Z1U7|B7Z1U7_HUMAN;tr|F8VZG9|F8VZG9_HUMAN;tr|B0QYY6|B0QYY6_HUMAN;sp|A6NFN3|RFOX3_HUMAN;tr|J3QQZ2|J3QQZ2_HUMAN;tr|J3QRF4|J3QRF4_HUMAN;tr|A0A0G2JRD1|A0A0G2JRD1_HUMAN;tr|S4R3K7|S4R3K7_HUMAN;tr|F5H0M1|F5H0M1_HUMAN;tr|F8VRS4|F8VRS4_HUMAN","tr|A0A0G2JSB3|A0A0G2JSB3_HUMAN;tr|I3L1D4|I3L1D4_HUMAN;tr|B0QYY7|B0QYY7_HUMAN;tr|S4R469|S4R469_HUMAN;tr|F8VR27|F8VR27_HUMAN;tr|F8VZY7|F8VZY7_HUMAN;tr|B0QYV1|B0QYV1_HUMAN;tr|B0QYY4|B0QYY4_HUMAN;tr|A0A087X2B1|A0A087X2B1_HUMAN;tr|A0A0G2JRA5|A0A0G2JRA5_HUMAN;sp|O43251|RFOX2_HUMAN;sp|Q9NWB1|RFOX1_HUMAN;tr|J3KNW3|J3KNW3_HUMAN;tr|B7Z1U7|B7Z1U7_HUMAN;tr|F8VZG9|F8VZG9_HUMAN;tr|B0QYY6|B0QYY6_HUMAN;sp|A6NFN3|RFOX3_HUMAN;tr|J3QQZ2|J3QQZ2_HUMAN;tr|J3QRF4|J3QRF4_HUMAN",397,"A0A0G2JSB3","A0A0G2JSB3_HUMAN",null,null,"RBFOX2"]
["23.7541",1,"22.7636","25.2263","21.2281","22.7839",{"$nulls":3},"rRNA processing;rRNA transcription","RNA binding","actin cytoskeleton;cytosol;nucleolus",{"$nulls":3},5,5,5,"48.3","48.3","48.3","19.343",0,"279.92",1063500000,34,"0.409009",1,"-7.24015","-0.963331","sp|O75607|NPM3_HUMAN","sp|O75607|NPM3_HUMAN",613,"O75607","NPM3_HUMAN","Nucleoplasmin-3",null,"NPM3"]
["25.0584",1,"24.7138","24.7075","23.4603","24.5012",{"$nulls":3},"chemical synaptic transmission;G-protein coupled receptor signaling pathway;muscle contraction;regulation of blood pressure;regulation of blood vessel diameter","hormone activity;receptor binding","extracellular region;extracellular space","Neuroactive ligand-receptor interaction",null,null,1,1,1,"6.5","6.5","6.5","14.295","0.0026667","2.895",1642400000,15,"0.385426",1,"-7.29894","-0.915573","sp|O95399|UTS2_HUMAN;tr|Q5H8X8|Q5H8X8_HUMAN","sp|O95399|UTS2_HUMAN;tr|Q5H8X8|Q5H8X8_HUMAN",752,"O95399","UTS2_HUMAN","Urotensin-2",null,"UTS2"]
[1,"23.0802","23.0517","23.4218","22.9716","22.6386",{"$nulls":9},4,4,4,"42.9","42.9","42.9","9.5594",0,"10.14",524670000,11,"0.423259",1,"-7.29999","-0.992004","tr|M0QXF7|M0QXF7_HUMAN;sp|Q969H8|MYDGF_HUMAN;tr|M0QYN0|M0QYN0_HUMAN","tr|M0QXF7|M0QXF7_HUMAN;sp|Q969H8|MYDGF_HUMAN;tr|M0QYN0|M0QYN0_HUMAN",3760,"M0QXF7","M0QXF7_HUMAN",null,null,"MYDGF"]
["25.2547","24.6428",1,"25.2979","24.4451","23.8131",{"$nulls":3},"apoptotic process;BMP signaling pathway;cellular protein modification process;DNA repair;MyD88-independent toll-like receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;positive regulation of protein targeting to mitochondrion;proteasome-mediated ubiquitin-dependent protein catabolic process;protein autoubiquitination;protein K11-linked ubiquitination;protein K48-linked ubiquitination;protein monoubiquitination;protein polyubiquitination;protein ubiquitination;regulation of transcription from RNA polymerase II promoter in response to hypoxia;TRIF-dependent toll-like receptor signaling pathway;ubiquitin-dependent protein catabolic process","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin-protein transferase activity","cytosol;endosome membrane;extracellular exosome;nucleoplasm;plasma membrane","Protein processing in endoplasmic reticulum;Shigellosis;Ubiquitin mediated proteolysis",null,null,3,3,2,"24.5","24.5","12.2","16.687",0,"18.599",831140000,9,"0.3997",1,"-7.55286","-0.944527","sp|P61077|UB2D3_HUMAN;tr|A0A087WY85|A0A087WY85_HUMAN;tr|D6RAW0|D6RAW0_HUMAN;tr|D6RA11|D6RA11_HUMAN;tr|D6RFM0|D6RFM0_HUMAN;tr|D6RAH7|D6RAH7_HUMAN;tr|H9KV45|H9KV45_HUMAN;tr|A0A0A0MQU3|A0A0A0MQU3_HUMAN;sp|P62837|UB2D2_HUMAN;tr|D6R9F6|D6R9F6_HUMAN;tr|D6R933|D6R933_HUMAN;tr|D6RGD0|D6RGD0_HUMAN;tr|D6R980|D6R980_HUMAN;tr|D6RIZ3|D6RIZ3_HUMAN","sp|P61077|UB2D3_HUMAN;tr|A0A087WY85|A0A087WY85_HUMAN;tr|D6RAW0|D6RAW0_HUMAN;tr|D6RA11|D6RA11_HUMAN;tr|D6RFM0|D6RFM0_HUMAN;tr|D6RAH7|D6RAH7_HUMAN;tr|H9KV45|H9KV45_HUMAN;tr|A0A0A0MQU3|A0A0A0MQU3_HUMAN;sp|P62837|UB2D2_HUMAN",1914,"P61077","UB2D3_HUMAN","Ubiquitin-conjugating enzyme E2 D3",null,"UBE2D3"]
[1,"16.2243","16.9259","20.263","17.9408","19.8055",{"$nulls":3},"multicellular organism development;negative regulation of ERK1 and ERK2 cascade",null,"cytoplasm;focal adhesion;ruffle membrane",{"$nulls":3},3,3,3,"15.7","15.7","15.7","32.541",0,"16.749",71615000,6,"0.69046",1,"-7.95306","-1.51661","sp|Q9C004|SPY4_HUMAN;tr|A0A0C4DFS6|A0A0C4DFS6_HUMAN;tr|D6RB56|D6RB56_HUMAN","sp|Q9C004|SPY4_HUMAN;tr|A0A0C4DFS6|A0A0C4DFS6_HUMAN",4344,"Q9C004","SPY4_HUMAN","Protein sprouty homolog 4","pry-4","SPRY4"]
[1,"12.9764",1,"14.0637","12.0313","14.2792",{"$nulls":3},"blood coagulation;small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity","cytosol;perinuclear region of cytoplasm",{"$nulls":3},4,3,3,"2.3",2,2,"229.56",0,"5.5851",12508000,3,"0.9782",1,"-8.46592","-2.08733","sp|Q96HP0|DOCK6_HUMAN;tr|K7ESB7|K7ESB7_HUMAN;tr|K7EP20|K7EP20_HUMAN","sp|Q96HP0|DOCK6_HUMAN;tr|K7ESB7|K7ESB7_HUMAN",3912,"Q96HP0","DOCK6_HUMAN","Dedicator of cytokinesis protein 6",null,"DOCK6"]
[1,"15.5046",1,"14.5953","14.8507","14.8635",{"$nulls":3},"actin filament depolymerization;blood coagulation;cytoskeleton organization;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of protein phosphorylation;oxidation-reduction process;regulation of regulated secretory pathway;signal transduction;sulfur oxidation","actin binding;FAD binding;metal ion binding;monooxygenase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;protein kinase binding;Rab GTPase binding;SH3 domain binding","cytoplasm;cytosol;hippocampal mossy fiber expansion;intermediate filament;midbody",{"$nulls":3},4,4,4,"5.6","5.6","5.6","117.87",0,"6.0862",25048000,4,"0.859006",1,"-8.93493","-1.84772","sp|Q8TDZ2|MICA1_HUMAN","sp|Q8TDZ2|MICA1_HUMAN",3569,"Q8TDZ2","MICA1_HUMAN","[F-actin]-monooxygenase MICAL1 {ECO:0000305}",null,"MICAL1"]
["16.212",1,1,"15.7423","14.9184","14.6578",{"$nulls":3},"cell division;cell migration;cell proliferation;epithelial to mesenchymal transition;metaphase plate congression;positive regulation of cell cycle G1/S phase transition;protein localization to mitotic spindle;regulation of ERK1 and ERK2 cascade;regulation of protein catabolic process;regulation of TOR signaling","kinesin binding;microtubule binding;protein kinase binding","cytoplasm;mitotic spindle pole",{"$nulls":3},6,6,6,"13.5","13.5","13.5","64.424",0,"16.17",80979000,14,"0.823929",1,"-9.03552","-1.77823","sp|Q9H4H8|FA83D_HUMAN;tr|A0A087WXK8|A0A087WXK8_HUMAN","sp|Q9H4H8|FA83D_HUMAN;tr|A0A087WXK8|A0A087WXK8_HUMAN",4467,"Q9H4H8","FA83D_HUMAN","Protein FAM83D {ECO:0000305}",null,"FAM83D"]
[1,1,"16.276","16.0774","14.2042","15.678",{"$nulls":5},"intracellular membrane-bounded organelle",{"$nulls":3},3,3,3,"7.1","7.1","7.1","105.55","0.00042355","4.6528",31171000,6,"0.835446",1,"-9.22789","-1.801","tr|B1AKL4|B1AKL4_HUMAN;sp|Q9NRA8|4ET_HUMAN","tr|B1AKL4|B1AKL4_HUMAN;sp|Q9NRA8|4ET_HUMAN",4682,"B1AKL4","B1AKL4_HUMAN",null,null,"EIF4ENIF1"]
[1,"12.4881",1,"15.3336","11.71","15.2642",{"$nulls":3},"endosome localization;protein transport;renal water homeostasis;vesicle-mediated transport","actin binding;ATP binding;calmodulin binding;microfilament motor activity;Rab GTPase binding","apical cortex;cytoplasmic vesicle membrane;extracellular exosome;myosin complex;protein complex",{"$nulls":3},18,15,15,"13.8","12.1","12.1","213.67",0,"63.301",217150000,34,"1.08669",1,"-9.27325","-2.31142","sp|Q9ULV0|MYO5B_HUMAN;tr|Q7Z7A5|Q7Z7A5_HUMAN;tr|A0A0A0MR36|A0A0A0MR36_HUMAN;tr|K7EPI3|K7EPI3_HUMAN","sp|Q9ULV0|MYO5B_HUMAN;tr|Q7Z7A5|Q7Z7A5_HUMAN",5132,"Q9ULV0","MYO5B_HUMAN","Unconventional myosin-Vb",null,"MYO5B"]
[1,"18.8664",1,"13.6977","18.8598","16.4797",{"$nulls":3},"phosphatidylserine acyl-chain remodeling","cholesterol binding;phosphatidylserine binding;phospholipid transporter activity","cytoskeleton;cytosol",{"$nulls":3},4,3,3,"6.4","5.1","5.1","83.969",0,"6.4285",87383000,4,"0.697071",1,"-9.39027","-1.5295","sp|Q9BXB5|OSB10_HUMAN;tr|H7C487|H7C487_HUMAN","sp|Q9BXB5|OSB10_HUMAN;tr|H7C487|H7C487_HUMAN",4289,"Q9BXB5","OSB10_HUMAN","Oxysterol-binding protein-related protein 10","RP-10;SBP-related protein 10","OSBPL10"]
["16.415",1,1,"16.4599","13.3801","17.0325",{"$nulls":4},"nucleic acid binding",{"$nulls":4},3,3,3,"5.8","5.8","5.8","93.287",0,"21.73",37659000,10,"0.836302",1,"-9.48583","-1.8027","tr|H3BQQ2|H3BQQ2_HUMAN;sp|Q86UK7|ZN598_HUMAN;tr|H3BR87|H3BR87_HUMAN","tr|H3BQQ2|H3BQQ2_HUMAN;sp|Q86UK7|ZN598_HUMAN;tr|H3BR87|H3BR87_HUMAN",3218,"H3BQQ2","H3BQQ2_HUMAN",null,null,"ZNF598"]
[1,"13.9599",1,"15.3651","14.5418","14.8293",{"$nulls":3},"androgen receptor signaling pathway;cellular response to leukemia inhibitory factor;formaldehyde biosynthetic process;histone H3-K9 demethylation;histone H3-K9 dimethylation;hormone-mediated signaling pathway;negative regulation of histone H3-K9 methylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of stem cell differentiation;regulation of stem cell population maintenance;spermatid nucleus elongation;transcription, DNA-templated","androgen receptor binding;chromatin DNA binding;core promoter binding;dioxygenase activity;DNA binding transcription factor activity;histone demethylase activity;histone demethylase activity (H3-K9 specific);iron ion binding;transcription regulatory region sequence-specific DNA binding","chromatin;cytoplasm;membrane;nucleoplasm;nucleus","Thermogenesis",null,null,5,3,3,"5.6","3.9","3.9","147.34","0.00021533","5.054",10185000,3,"1.04134",1,"-9.59208","-2.21695","sp|Q9Y4C1|KDM3A_HUMAN;tr|F5H070|F5H070_HUMAN;tr|F8WE62|F8WE62_HUMAN;tr|C9JC73|C9JC73_HUMAN;tr|C9J7Q7|C9J7Q7_HUMAN","sp|Q9Y4C1|KDM3A_HUMAN;tr|F5H070|F5H070_HUMAN",5320,"Q9Y4C1","KDM3A_HUMAN","Lysine-specific demethylase 3A",null,"KDM3A"]
["16.2272",1,1,"17.3592","14.2224","15.8014",{"$nulls":3},"apoptotic process;endocytosis;membrane fusion;protein transport;vesicle-mediated transport","growth factor activity;GTPase activator activity;protein domain specific binding;protein homodimerization activity","early endosome;early endosome membrane;endocytic vesicle;endosome;intracellular membrane-bounded organelle;protein complex;recycling endosome","Endocytosis",null,null,5,5,5,"6.4","6.4","6.4","99.289",0,"11.568",42939000,8,"0.877715",1,"-9.71859","-1.88495","sp|Q15276|RABE1_HUMAN;tr|I3L2B8|I3L2B8_HUMAN","sp|Q15276|RABE1_HUMAN",2575,"Q15276","RABE1_HUMAN","Rab GTPase-binding effector protein 1",null,"RABEP1"]
[1,"14.2933",1,"16.35","14.2221","14.9243",{"$nulls":3},"muscle organ development;smooth muscle contraction","actin binding;structural constituent of muscle","actin cytoskeleton;cytoplasm;cytoskeleton",{"$nulls":3},2,2,2,"3.6","3.6","3.6","99.058","0.0084126","2.2681",11234000,2,"1.02113",1,"-9.73436","-2.17522","sp|P53814|SMTN_HUMAN;tr|A0A087WVP4|A0A087WVP4_HUMAN;tr|A0A087X1R1|A0A087X1R1_HUMAN;tr|C9JP19|C9JP19_HUMAN;tr|C9JQZ8|C9JQZ8_HUMAN","sp|P53814|SMTN_HUMAN;tr|A0A087WVP4|A0A087WVP4_HUMAN;tr|A0A087X1R1|A0A087X1R1_HUMAN;tr|C9JP19|C9JP19_HUMAN;tr|C9JQZ8|C9JQZ8_HUMAN",1808,"P53814","SMTN_HUMAN","Smoothelin",null,"SMTN"]
[1,"15.1287",1,"15.8379","14.7004","16.0039",{"$nulls":3},"camera-type eye photoreceptor cell differentiation;glomerular parietal epithelial cell differentiation;glomerular visceral epithelial cell differentiation;photoreceptor cell maintenance;positive regulation of nephron tubule epithelial cell differentiation;retina layer formation;retina morphogenesis in camera-type eye","actinin binding;cadherin binding","apical plasma membrane;cell surface;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular space;integral component of plasma membrane;microvillus membrane;photoreceptor outer segment;photoreceptor outer segment membrane;plasma membrane;vesicle","Transcriptional misregulation in cancer",null,null,1,1,1,"1.5","1.5","1.5","97.201","0.0010095","3.6943",15671000,3,"0.971653",1,"-9.80453","-2.074","sp|O43490|PROM1_HUMAN","sp|O43490|PROM1_HUMAN",425,"O43490","PROM1_HUMAN","Prominin-1",null,"PROM1"]
[1,"13.6699",1,"15.4627","14.1662","15.467",{"$nulls":3},"cellular respiration;mitochondrial RNA metabolic process;regulation of mitochondrial mRNA stability","protein kinase activity;RNA binding","mitochondrion",{"$nulls":3},1,1,1,"1.3","1.3","1.3","97.41","0.0071625","2.3202",17374000,4,"1.08621",1,"-9.80866","-2.31041","sp|Q53R41|FAKD1_HUMAN","sp|Q53R41|FAKD1_HUMAN",2788,"Q53R41","FAKD1_HUMAN","FAST kinase domain-containing protein 1, mitochondrial",null,"FASTKD1"]
[1,"18.2904",1,"17.3929","16.8599","15.5204",{"$nulls":3},"cellular protein modification process;collagen catabolic process;endodermal cell differentiation;extracellular matrix disassembly;proteolysis;response to estradiol","enzyme activator activity;metalloaminopeptidase activity;metalloendopeptidase activity;zinc ion binding","extracellular matrix;integral component of plasma membrane;plasma membrane","Parathyroid hormone synthesis, secretion and action",null,null,6,6,6,"13.9","13.9","13.9","75.806",0,"13.385",49525000,7,"0.782817",1,"-9.8276","-1.69725","sp|P51511|MMP15_HUMAN;tr|H3BT97|H3BT97_HUMAN","sp|P51511|MMP15_HUMAN",1736,"P51511","MMP15_HUMAN","Matrix metalloproteinase-15","MP-15","MMP15"]
["18.2336",1,1,"18.1072","14.2809","17.6123",{"$nulls":3},"cellular response to DNA damage stimulus;DNA recombination;DNA repair;DNA replication;mRNA processing;protein methylation;viral process","DNA binding;double-stranded DNA binding;metal ion binding;RNA binding","cytoplasm;intracellular membrane-bounded organelle;nuclear matrix;nucleoplasm;nucleus;protein complex",{"$nulls":3},5,5,5,"17.8","17.8","17.8","45.373",0,"13.591",69960000,20,"0.779469",1,"-9.92228","-1.69067","sp|O60870|KIN17_HUMAN;tr|S4R357|S4R357_HUMAN","sp|O60870|KIN17_HUMAN;tr|S4R357|S4R357_HUMAN",532,"O60870","KIN17_HUMAN","DNA/RNA-binding protein KIN17",null,"KIN"]
[1,"13.8526",1,"17.1736","13.189","15.4326",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);positive regulation of protein targeting to mitochondrion;rRNA processing","RNA binding","90S preribosome;nucleolus;nucleoplasm;small-subunit processome",{"$nulls":3},6,6,6,"16.4","16.4","16.4","68.07",0,"26.27",52671000,5,"1.05708",1,"-9.98087","-2.2496","sp|O15213|WDR46_HUMAN;tr|H0Y6G3|H0Y6G3_HUMAN;tr|A0A0G2JJL1|A0A0G2JJL1_HUMAN","sp|O15213|WDR46_HUMAN",346,"O15213","WDR46_HUMAN","WD repeat-containing protein 46",null,"WDR46"]
["15.8836",1,1,"17.3823","15.1038","15.4334",{"$nulls":3},"muscle contraction",null,"integral component of membrane",{"$nulls":3},4,4,4,"15.2","15.2","15.2","42.036",0,"6.3091",19930000,1,"0.933936",1,"-10.012","-1.99764","tr|B7Z964|B7Z964_HUMAN;tr|H7C3M8|H7C3M8_HUMAN;tr|H7BZK0|H7BZK0_HUMAN;sp|Q14BN4|SLMAP_HUMAN;tr|H7BZW9|H7BZW9_HUMAN;tr|B7Z863|B7Z863_HUMAN;tr|C9JA20|C9JA20_HUMAN;tr|C9JCH4|C9JCH4_HUMAN","tr|B7Z964|B7Z964_HUMAN;tr|H7C3M8|H7C3M8_HUMAN;tr|H7BZK0|H7BZK0_HUMAN;sp|Q14BN4|SLMAP_HUMAN;tr|H7BZW9|H7BZW9_HUMAN;tr|B7Z863|B7Z863_HUMAN;tr|C9JA20|C9JA20_HUMAN;tr|C9JCH4|C9JCH4_HUMAN",2523,"B7Z964","B7Z964_HUMAN",null,null,"SLMAP"]
[1,1,"15.6632","16.8312","15.444","15.4852",{"$nulls":3},"heme biosynthetic process;mitochondrion organization;protoporphyrinogen IX biosynthetic process;regulation of lipid metabolic process","5-aminolevulinate synthase activity;identical protein binding;pyridoxal phosphate binding","cytosol;mitochondrial matrix;mitochondrion;nucleoplasm","Glycine, serine and threonine metabolism;Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,3,3,3,"8.9","8.9","8.9","70.58",0,"7.6493",49110000,12,"0.956732",1,"-10.0324","-2.04372","sp|P13196|HEM1_HUMAN","sp|P13196|HEM1_HUMAN",1077,"P13196","HEM1_HUMAN","5-aminolevulinate synthase, nonspecific, mitochondrial","LAS-H","ALAS1"]
[1,1,"15.457","18.0482","14.2291","15.6441",{"$nulls":5},"nucleus",{"$nulls":3},4,4,3,"12.8","12.8","9.5","54.813",0,"9.4294",32859000,5,"0.961328",1,"-10.1548","-2.05304","sp|Q12894|IFRD2_HUMAN;tr|H7C444|H7C444_HUMAN","sp|Q12894|IFRD2_HUMAN;tr|H7C444|H7C444_HUMAN",2275,"Q12894","IFRD2_HUMAN","Interferon-related developmental regulator 2",null,"IFRD2"]
[1,1,"18.9107","17.8096","14.972","18.67",{"$nulls":3},"protein tetramerization;UDP-D-xylose biosynthetic process","NAD+ binding;protein homodimerization activity;UDP-glucuronate decarboxylase activity","cytoplasm;extracellular exosome;Golgi cisterna membrane;integral component of membrane;mitochondrion","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,7,7,7,"27.4","27.4","27.4","47.576",0,"31.002",322970000,42,"0.772038",1,"-10.1803","-1.67609","sp|Q8NBZ7|UXS1_HUMAN;tr|C9JCB7|C9JCB7_HUMAN;tr|C9JFU6|C9JFU6_HUMAN;tr|C9JE50|C9JE50_HUMAN;tr|C9JW33|C9JW33_HUMAN;tr|C9J3T9|C9J3T9_HUMAN","sp|Q8NBZ7|UXS1_HUMAN",3465,"Q8NBZ7","UXS1_HUMAN","UDP-glucuronic acid decarboxylase 1",null,"UXS1"]
[1,"15.5042",1,"15.6033","15.7671","16.6836",{"$nulls":3},"calcium ion transport into cytosol;muscle organ development;regulation of ryanodine-sensitive calcium-release channel activity","structural constituent of muscle","integral component of membrane;junctional membrane complex;junctional sarcoplasmic reticulum membrane;plasma membrane;Z disc",{"$nulls":3},7,7,7,"16.9","16.9","16.9","71.685",0,"37.329",240140000,21,"0.985007",1,"-10.1833","-2.1012","sp|Q9HDC5|JPH1_HUMAN","sp|Q9HDC5|JPH1_HUMAN",4614,"Q9HDC5","JPH1_HUMAN","Junctophilin-1","P-1","JPH1"]
[1,1,"17.5179","17.5198","15.8603","16.8143",{"$nulls":3},"defense response to virus;JAK-STAT cascade;regulation of mitochondrial fission;regulation of protein phosphorylation;regulation of transcription from RNA polymerase II promoter;regulation of type I interferon-mediated signaling pathway;transcription, DNA-templated;type I interferon signaling pathway;viral process","DNA binding;DNA binding transcription factor activity;identical protein binding;signal transducer activity;ubiquitin-like protein ligase binding","cytosol;nucleoplasm;plasma membrane","Chemokine signaling pathway;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human papillomavirus infection;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pathways in cancer",null,null,6,6,6,"9.4","9.4","9.4","97.915",0,"14.213",54082000,9,"0.860215",1,"-10.2255","-1.85012","sp|P52630|STAT2_HUMAN;tr|B4DLC8|B4DLC8_HUMAN","sp|P52630|STAT2_HUMAN;tr|B4DLC8|B4DLC8_HUMAN",1774,"P52630","STAT2_HUMAN","Signal transducer and activator of transcription 2",null,"STAT2"]
[1,"16.0475",1,"16.3207","15.6044","16.8318",{"$nulls":3},"androgen receptor signaling pathway;intracellular steroid hormone receptor signaling pathway;positive regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","ligand-dependent nuclear receptor transcription coactivator activity;receptor activity;RNA polymerase II transcription cofactor activity;thyroid hormone receptor binding;transcription cofactor activity;vitamin D receptor binding","core mediator complex;mediator complex;membrane;nucleoplasm;nucleus","Thyroid hormone signaling pathway",null,null,3,3,3,"16.7","16.7","16.7","29.745",0,"7.4433",21107000,4,"0.952778",1,"-10.2365","-2.03571","sp|Q9NPJ6|MED4_HUMAN;tr|Q5T911|Q5T911_HUMAN","sp|Q9NPJ6|MED4_HUMAN;tr|Q5T911|Q5T911_HUMAN",4644,"Q9NPJ6","MED4_HUMAN","Mediator of RNA polymerase II transcription subunit 4",null,"MED4"]
[1,"17.0002",1,"15.4416","17.6034","16.957",{"$nulls":3},"cell cycle;negative regulation of cell proliferation;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of transcription, DNA-templated;positive regulation of histone acetylation;positive regulation of transcription, DNA-templated;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;Wnt signaling pathway","histone binding;lysine-acetylated histone binding;p53 binding;transcription coactivator activity;transcription corepressor activity;transcription factor binding;transcription regulatory region DNA binding","cytoplasm;cytosol;nucleoplasm;nucleus","Hepatocellular carcinoma",null,null,10,10,10,"27.5","27.5","27.5","74.138",0,"79.398",392440000,32,"0.897144",1,"-10.3339","-1.92375","sp|Q9NPI1|BRD7_HUMAN;tr|I3L4V5|I3L4V5_HUMAN","sp|Q9NPI1|BRD7_HUMAN",4641,"Q9NPI1","BRD7_HUMAN","Bromodomain-containing protein 7",null,"BRD7"]
[1,1,"15.7606","17.8754","16.0728","15.7299",{"$nulls":3},"activation of store-operated calcium channel activity;cellular calcium ion homeostasis;positive regulation of calcium ion transport;store-operated calcium entry","calcium channel regulator activity;calcium ion binding;store-operated calcium channel activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;plasma membrane","Calcium signaling pathway",null,null,5,5,5,"8.6","8.6","8.6","83.97",0,"14.996",93140000,11,"1.00536",1,"-10.6391","-2.14282","sp|Q9P246|STIM2_HUMAN;tr|H0Y860|H0Y860_HUMAN;tr|H7C5A5|H7C5A5_HUMAN;tr|H7C5K2|H7C5K2_HUMAN;tr|H7C5C6|H7C5C6_HUMAN","sp|Q9P246|STIM2_HUMAN;tr|H0Y860|H0Y860_HUMAN;tr|H7C5A5|H7C5A5_HUMAN;tr|H7C5K2|H7C5K2_HUMAN",4920,"Q9P246","STIM2_HUMAN","Stromal interaction molecule 2",null,"STIM2"]
[1,1,"14.2797","17.1497","14.9068","16.3441",{"$nulls":3},"chromosome separation;female meiosis chromosome segregation;meiotic spindle assembly checkpoint;mitotic spindle assembly checkpoint;mitotic spindle organization;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of cell proliferation;positive regulation of pathway-restricted SMAD protein phosphorylation;protein autophosphorylation;protein localization to kinetochore;protein localization to meiotic spindle midzone;spindle organization","ATP binding;protein homodimerization activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity","cytoplasm;kinetochore;membrane;spindle","Cell cycle",null,null,9,9,9,"14.7","14.7","14.7","97.071",0,"24.723",112740000,14,"1.12523",1,"-10.707","-2.39268","sp|P33981|TTK_HUMAN;tr|D6RF82|D6RF82_HUMAN;tr|D6REX1|D6REX1_HUMAN;tr|D6RIC6|D6RIC6_HUMAN;tr|D6RFY1|D6RFY1_HUMAN","sp|P33981|TTK_HUMAN",1436,"P33981","TTK_HUMAN","Dual specificity protein kinase TTK",null,"TTK"]
[1,"16.4272",1,"17.0703","15.8479","17.7314",{"$nulls":3},"BMP signaling pathway;cell development;cell-cell signaling;positive regulation of myoblast fusion;positive regulation of pathway-restricted SMAD protein phosphorylation;regulation of apoptotic process;regulation of MAPK cascade;signal transduction;SMAD protein signal transduction;transforming growth factor beta receptor signaling pathway","cytokine activity;growth factor activity;transforming growth factor beta receptor binding","cytoplasm;extracellular exosome;extracellular region;extracellular space;nucleus","Cytokine-cytokine receptor interaction",null,null,6,6,6,"34.4","34.4","34.4","34.14",0,"19.427",118030000,15,"0.973005",1,"-10.7408","-2.07676","sp|Q99988|GDF15_HUMAN;tr|A0A0A0MTT8|A0A0A0MTT8_HUMAN","sp|Q99988|GDF15_HUMAN",4124,"Q99988","GDF15_HUMAN","Growth/differentiation factor 15","DF-15","GDF15"]
[1,"15.8777",1,"18.0637","15.5302","17.7221",{"$nulls":3},"apoptotic process;early endosome to late endosome transport;endosome organization;endosome to lysosome transport;lysosome organization;positive regulation of protein binding;positive regulation of protein phosphorylation;protein transport","ubiquitin protein ligase activity;ubiquitin protein ligase binding","cytosol;FHF complex;plasma membrane",{"$nulls":3},1,1,1,"7.2","7.2","7.2","33.128","0.0078827","2.2971",11951000,2,"1.04247",1,"-11.1461","-2.21929","sp|Q9H8T0|AKTIP_HUMAN","sp|Q9H8T0|AKTIP_HUMAN",4523,"Q9H8T0","AKTIP_HUMAN","AKT-interacting protein",null,"AKTIP"]
[1,"15.0463",1,"18.095","16.1778","16.7191",{"$nulls":3},"activation of GTPase activity;cell cycle;endocytosis;intracellular protein transport;regulation of protein localization;regulation of vesicle fusion","GTPase activator activity;Rab GTPase binding","early endosome;Golgi apparatus;nucleus",{"$nulls":3},7,7,6,"11.7","11.7","10.2","92.512",0,"12.924",51370000,7,"1.12818",1,"-11.3152","-2.39894","sp|Q5R372|RBG1L_HUMAN;tr|A0A0C4DG54|A0A0C4DG54_HUMAN","sp|Q5R372|RBG1L_HUMAN;tr|A0A0C4DG54|A0A0C4DG54_HUMAN",2842,"Q5R372","RBG1L_HUMAN","Rab GTPase-activating protein 1-like",null,"RABGAP1L"]
[1,"14.827",1,"17.832","16.3261","17.1155",{"$nulls":3},"fructose 2,6-bisphosphate metabolic process;fructose metabolic process","6-phosphofructo-2-kinase activity;ATP binding","nucleoplasm",{"$nulls":3},2,2,2,"6.2","6.2","6.2","52.584","0.00042176","4.5922",26511000,4,"1.16626",1,"-11.4822","-2.48024","tr|F2Z2I2|F2Z2I2_HUMAN;tr|Q5W015|Q5W015_HUMAN;sp|Q16875|F263_HUMAN;tr|Q5VX20|Q5VX20_HUMAN","tr|F2Z2I2|F2Z2I2_HUMAN;tr|Q5W015|Q5W015_HUMAN;sp|Q16875|F263_HUMAN;tr|Q5VX20|Q5VX20_HUMAN",2702,"F2Z2I2","F2Z2I2_HUMAN",null,null,"PFKFB3"]
[1,"16.3149",1,"18.1999","16.6502","17.9808",{"$nulls":3},"mitotic centrosome separation;nervous system development;neurofilament cytoskeleton organization;regulation of microtubule motor activity",{"$nulls":5},2,2,1,"14.5","14.5","6.9","17.242","0.00041246","4.1376",78558000,4,"1.05423",1,"-11.5053","-2.24368","tr|J3KRK9|J3KRK9_HUMAN;tr|J3QL85|J3QL85_HUMAN;tr|A6NIZ0|A6NIZ0_HUMAN;sp|Q9GZM8|NDEL1_HUMAN;tr|I3L3G9|I3L3G9_HUMAN;tr|I3L2S8|I3L2S8_HUMAN","tr|J3KRK9|J3KRK9_HUMAN;tr|J3QL85|J3QL85_HUMAN;tr|A6NIZ0|A6NIZ0_HUMAN;sp|Q9GZM8|NDEL1_HUMAN;tr|I3L3G9|I3L3G9_HUMAN;tr|I3L2S8|I3L2S8_HUMAN",4359,"J3KRK9","J3KRK9_HUMAN",null,null,"NDEL1"]
[1,"14.6231",1,"17.5984","15.7145","18.4171",{"$nulls":3},"cell proliferation;endochondral ossification;myelination;negative regulation of transcription from RNA polymerase III promoter;nervous system development;positive regulation of tau-protein kinase activity;regulation of epidermis development;Schwann cell differentiation;transcription, DNA-templated","identical protein binding;transcription corepressor activity;transcription factor binding","nucleus",{"$nulls":3},3,3,2,"6.5","6.5","4.8","56.593","0.00021492","5.0249",29890000,2,"1.19298",1,"-11.7023","-2.53791","sp|Q15742|NAB2_HUMAN","sp|Q15742|NAB2_HUMAN",2637,"Q15742","NAB2_HUMAN","NGFI-A-binding protein 2",null,"NAB2"]
[1,1,"18.669","18.8823","18.074","19.2883",{"$nulls":5},"cytosol;integral component of membrane;nucleoplasm;plasma membrane",{"$nulls":3},3,3,3,"9.6","9.6","9.6","47.597",0,"8.2735",55771000,5,"0.939941",1,"-11.8585","-2.00976","tr|H0YH69|H0YH69_HUMAN;sp|Q9HBU6|EKI1_HUMAN;tr|H0YFP7|H0YFP7_HUMAN","tr|H0YH69|H0YH69_HUMAN;sp|Q9HBU6|EKI1_HUMAN",4580,"H0YH69","H0YH69_HUMAN",null,null,"ETNK1"]
[1,"16.351",1,"19.113","16.5989","18.2216",{"$nulls":9},3,3,3,"13.5","13.5","13.5","35.74","0.00042526","4.7637",25862000,2,"1.07853",1,"-11.8608","-2.29432","sp|Q6PL24|TMED8_HUMAN","sp|Q6PL24|TMED8_HUMAN",3042,"Q6PL24","TMED8_HUMAN","Protein TMED8",null,"TMED8"]
[1,"18.8527",1,"19.609","18.8497","17.9909",{"$nulls":3},"osteoblast differentiation;oxidation-reduction process;response to vitamin D;vitamin D catabolic process;vitamin D metabolic process;vitamin D receptor signaling pathway;vitamin metabolic process","1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity;25-hydroxycholecalciferol-24-hydroxylase activity;heme binding;iron ion binding;oxidoreductase activity","mitochondrial outer membrane;mitochondrion;nucleoplasm;nucleus;plasma membrane","Metabolic pathways;MicroRNAs in cancer;Parathyroid hormone synthesis, secretion and action;Steroid biosynthesis",null,null,3,3,3,7,7,7,"58.875",0,"6.5086",89501000,5,"0.929054",1,"-11.8657","-1.9878","sp|Q07973|CP24A_HUMAN","sp|Q07973|CP24A_HUMAN",2221,"Q07973","CP24A_HUMAN","1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial","4-OHase;itamin D(3) 24-hydroxylase","CYP24A1"]
["16.4724",1,1,"16.8668","18.5801","19.0636",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular response to DNA damage stimulus;histone H3-K4 methylation;post-translational protein modification;regulation of megakaryocyte differentiation;regulation of transcription, DNA-templated;response to estrogen;transcription, DNA-templated","histone-lysine N-methyltransferase activity;methylated histone binding;transcription regulatory region DNA binding","histone methyltransferase complex;MLL1 complex;MLL3/4 complex;nucleolus;nucleoplasm;nucleus;Set1C/COMPASS complex","Cushing syndrome",null,null,5,5,5,"12.1","12.1","12.1","59.152",0,"12.632",216260000,20,"1.086",1,"-12.0127","-2.30998","sp|Q15291|RBBP5_HUMAN","sp|Q15291|RBBP5_HUMAN",2579,"Q15291","RBBP5_HUMAN","Retinoblastoma-binding protein 5","BBP-5","RBBP5"]
["20.5537",1,1,"20.5082","18.7754","20.0288",{"$nulls":9},1,1,1,"37.7","37.7","37.7","5.9598",0,"10.059",14073000,4,"0.872225",1,"-12.2529","-1.87401","tr|E5RJ10|E5RJ10_HUMAN;tr|E5RHB8|E5RHB8_HUMAN;tr|E5RJX6|E5RJX6_HUMAN;tr|E5RG91|E5RG91_HUMAN;sp|Q8NEZ2|VP37A_HUMAN","tr|E5RJ10|E5RJ10_HUMAN;tr|E5RHB8|E5RHB8_HUMAN;tr|E5RJX6|E5RJX6_HUMAN;tr|E5RG91|E5RG91_HUMAN;sp|Q8NEZ2|VP37A_HUMAN",3497,"E5RJ10","E5RJ10_HUMAN",null,null,"VPS37A"]
[1,"18.3398",1,"20.5408","20.0469","18.963",{"$nulls":3},"mRNA splicing, via spliceosome;nuclear import;spliceosomal complex assembly;spliceosomal snRNP assembly",null,"cytoplasm;cytosol;Gemini of coiled bodies;nuclear body;nucleoplasm;SMN complex;SMN-Sm protein complex","RNA transport",null,null,4,4,4,"28.1","28.1","28.1","18.824",0,"27.329",121320000,9,"1.0592",1,"-13.0703","-2.25401","sp|Q8WXD5|GEMI6_HUMAN;tr|B9A037|B9A037_HUMAN;tr|B8ZZ85|B8ZZ85_HUMAN","sp|Q8WXD5|GEMI6_HUMAN",3643,"Q8WXD5","GEMI6_HUMAN","Gem-associated protein 6","emin-6","GEMIN6"]
[1,1,1,"15.9575","13.7739","15.249",{"$nulls":3},"cellular response to leukemia inhibitory factor;energy reserve metabolic process;fructose 6-phosphate metabolic process;glutamine metabolic process;protein N-linked glycosylation;UDP-N-acetylglucosamine biosynthetic process;UDP-N-acetylglucosamine metabolic process","carbohydrate derivative binding;glutamine-fructose-6-phosphate transaminase (isomerizing) activity","cytosol","Alanine, aspartate and glutamate metabolism;Amino sugar and nucleotide sugar metabolism;Insulin resistance;Metabolic pathways",null,null,9,4,4,"18.9","8.2","8.2","76.93",0,"7.8547",24555000,5,"4.57831",1,"-13.9935","-21.7566","sp|O94808|GFPT2_HUMAN;tr|E5RJP4|E5RJP4_HUMAN","sp|O94808|GFPT2_HUMAN;tr|E5RJP4|E5RJP4_HUMAN",677,"O94808","GFPT2_HUMAN","Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2",null,"GFPT2"]
[1,1,1,"18.0835","14.0201","17.8433",{"$nulls":3},"cell proliferation;glucose metabolic process;hypoxia-inducible factor-1alpha signaling pathway;intrinsic apoptotic signaling pathway in response to oxidative stress;regulation of acetyl-CoA biosynthetic process from pyruvate;regulation of glucose metabolic process","ATP binding;protein kinase activity;pyruvate dehydrogenase (acetyl-transferring) kinase activity","mitochondrial matrix;mitochondrial pyruvate dehydrogenase complex;mitochondrion;nucleolus;nucleus","Axon guidance;Central carbon metabolism in cancer;HIF-1 signaling pathway",null,null,3,3,3,8,8,8,"49.244","0.00041271","4.1433",21375000,1,"3.54263",1,"-15.649","-11.8889","sp|Q15118|PDK1_HUMAN;tr|F8WC75|F8WC75_HUMAN;tr|C9JKT3|C9JKT3_HUMAN;tr|F8WEJ6|F8WEJ6_HUMAN;tr|C9IYB4|C9IYB4_HUMAN","sp|Q15118|PDK1_HUMAN",2560,"Q15118","PDK1_HUMAN","[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial",null,"PDK1"]
[1,1,1,"18.0257","17.0138","16.3836",{"$nulls":4},"transferase activity, transferring hexosyl groups",{"$nulls":4},3,3,1,21,21,"4.3","17.801","0.0043023","2.6015",36477000,3,"5.3374",1,"-16.141","-33.7485","tr|A0A096LP10|A0A096LP10_HUMAN;tr|A0A087WT15|A0A087WT15_HUMAN","tr|A0A096LP10|A0A096LP10_HUMAN",5443,"A0A096LP10","A0A096LP10_HUMAN",null,null,"ALG13"]
[1,1,1,"19.2526","17.1755","18.1341",{"$nulls":9},2,2,2,"14.9","14.9","14.9","21.529",0,"6.02",23433000,1,"5.05307",1,"-17.1874","-28.6369","tr|D6RJ90|D6RJ90_HUMAN;sp|Q9Y6G5|COMDA_HUMAN;tr|H0Y9N4|H0Y9N4_HUMAN;tr|D6RC04|D6RC04_HUMAN","tr|D6RJ90|D6RJ90_HUMAN;sp|Q9Y6G5|COMDA_HUMAN;tr|H0Y9N4|H0Y9N4_HUMAN;tr|D6RC04|D6RC04_HUMAN",5407,"D6RJ90","D6RJ90_HUMAN"]
[1,1,1,"19.6257","17.0328","19.436",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,17,17,17,"10.809","0.0035687","2.6738",16635000,1,"4.53431",1,"-17.6982","-21.2087","tr|A0A096LPB2|A0A096LPB2_HUMAN;tr|A0A096LP01|A0A096LP01_HUMAN","tr|A0A096LPB2|A0A096LPB2_HUMAN;tr|A0A096LP01|A0A096LP01_HUMAN",5442,"A0A096LPB2","A0A096LPB2_HUMAN",null,null,"SMIM26"]
[1,1,1,"19.8363","18.4446","19.4707",{"$nulls":3},"cytoplasmic microtubule organization;microtubule depolymerization;negative regulation of Rac protein signal transduction;nervous system development;neuron projection development;regulation of cytoskeleton organization;regulation of GTPase activity;regulation of microtubule polymerization or depolymerization","protein domain specific binding;tubulin binding","axon;cytoplasm;Golgi apparatus;growth cone;neuron projection",{"$nulls":3},2,2,2,10,10,10,"21.017","0.002842","2.7833",25226000,3,"5.78967",1,"-18.2505","-43.8106","sp|Q9NZ72|STMN3_HUMAN;tr|A0A0J9YW36|A0A0J9YW36_HUMAN","sp|Q9NZ72|STMN3_HUMAN;tr|A0A0J9YW36|A0A0J9YW36_HUMAN",4870,"Q9NZ72","STMN3_HUMAN","Stathmin-3",null,"STMN3"]

{"sheet":"HCT116_Signproteins_3DsiKvssiC","index":1,"n_rows":68,"n_cols":38,"rows_kept":68}
["3D siKRAS 3","3D siKRAS 1","3D siKRAS 2","3D NT 3","3D NT 1","3D NT 2","C: Only identified by site","C: Reverse","C: Potential contaminant","C: GOBP name","C: GOMF name","C: GOCC name","C: KEGG pathway name","C: Student's T-test Significant 3D siKRAS_3D NT","C: Student's T-test significant","N: Peptides","N: Razor + unique peptides","N: Unique peptides","N: Sequence coverage [%]","N: Unique + razor sequence coverage [%]","N: Unique sequence coverage [%]","N: Mol. weight [kDa]","N: Q-value","N: Score","N: Intensity","N: MS/MS Count","N: -Log Student's T-test p-value 3D siKRAS_3D NT","N: Student's T-test q-value 3D siKRAS_3D NT","N: Student's T-test Difference 3D siKRAS_3D NT","N: Student's T-test Test statistic 3D siKRAS_3D NT","T: Protein IDs","T: Majority protein IDs","T: id","T: Uniprot IDs","T: Uniprot name","T: Uniprot full protein name","T: Uniprot short protein name","T: Gene name"]
["22.4858","21.2949","20.7507",1,1,1,{"$nulls":3},"ATP biosynthetic process;cristae formation;mitochondrial ATP synthesis coupled proton transport;proton transport","transmembrane transporter activity","extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);mitochondrion;nucleoplasm;nucleus","Metabolic pathways;Oxidative phosphorylation;Thermogenesis",null,null,3,1,1,"39.4","13.8","13.8","10.918","0.0010079","3.6725",168510000,10,"5.63332",1,"20.5105","40.0328","sp|P56134|ATPK_HUMAN;tr|C9JU26|C9JU26_HUMAN","sp|P56134|ATPK_HUMAN;tr|C9JU26|C9JU26_HUMAN",1859,"P56134","ATPK_HUMAN","ATP synthase subunit f, mitochondrial",null,"ATP5J2"]
["18.9633","16.7211","18.1094",1,1,1,{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;humoral immune response;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;nucleoplasm;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex;spermatoproteasome complex","Proteasome",null,null,2,2,2,"9.9","9.9","9.9","28.936","0.001006","3.6442",20866000,5,"4.88026",1,"16.9312","25.9136","sp|P40306|PSB10_HUMAN;tr|J3QQN1|J3QQN1_HUMAN","sp|P40306|PSB10_HUMAN;tr|J3QQN1|J3QQN1_HUMAN",1516,"P40306","PSB10_HUMAN","Proteasome subunit beta type-10",null,"PSMB10"]
["16.8285","17.3978","16.1037",1,1,1,{"$nulls":3},"ribosomal large subunit assembly","RNA binding;rRNA binding","nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},5,5,5,"18.2","18.2","18.2","53.193",0,"33.09",66090000,13,"5.72177",1,"15.7767","42.1282","sp|Q9NQ55|SSF1_HUMAN;tr|A0A0A6YYI3|A0A0A6YYI3_HUMAN;tr|A0A0B4J1V8|A0A0B4J1V8_HUMAN;tr|A8MV53|A8MV53_HUMAN;tr|H7C446|H7C446_HUMAN;tr|C9J3W3|C9J3W3_HUMAN","sp|Q9NQ55|SSF1_HUMAN;tr|A0A0A6YYI3|A0A0A6YYI3_HUMAN;tr|A0A0B4J1V8|A0A0B4J1V8_HUMAN;tr|A8MV53|A8MV53_HUMAN;tr|H7C446|H7C446_HUMAN",4651,"Q9NQ55","SSF1_HUMAN","Suppressor of SWI4 1 homolog","sf-1","PPAN"]
["17.3073","15.0323","17.3852",1,1,1,{"$nulls":3},"negative regulation of peptidyl-lysine crotonylation;random inactivation of X chromosome;regulation of transcription, DNA-templated;spermatid development;spermatogenesis;transcription, DNA-templated","chromatin binding;crotonyl-CoA hydratase activity;methylated histone binding;protein binding, bridging;transcription corepressor activity","chromosome;nuclear body;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"4.7","4.7","4.7","66.481",0,"7.6303",23179000,7,"4.44894",1,"15.5749","20.1838","sp|Q9Y232|CDYL1_HUMAN;tr|C9JQG7|C9JQG7_HUMAN","sp|Q9Y232|CDYL1_HUMAN;tr|C9JQG7|C9JQG7_HUMAN",5199,"Q9Y232","CDYL_HUMAN","Chromodomain Y-like protein {ECO:0000303|PubMed:10192397}","DY-like {ECO:0000303|PubMed:10192397}","CDYL"]
["18.3204","13.47","17.3354",1,1,1,{"$nulls":3},"DNA recombination;DNA repair;forebrain morphogenesis;lateral ventricle development;midbrain development;protein deubiquitination;regulation of proteasomal protein catabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated;ubiquitin-dependent protein catabolic process","endopeptidase inhibitor activity;proteasome binding;RNA binding;thiol-dependent ubiquitin-specific protease activity","cytosol;cytosolic proteasome complex;Ino80 complex;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},15,1,1,"55.6","7.9","7.9","37.606","0.00042017","4.4894",20651000,2,"3.31424",1,"15.3753","10.3873","sp|Q9Y5K5|UCHL5_HUMAN;tr|Q5LJA9|Q5LJA9_HUMAN;tr|H0Y6Y4|H0Y6Y4_HUMAN;tr|H0Y4E0|H0Y4E0_HUMAN","sp|Q9Y5K5|UCHL5_HUMAN;tr|Q5LJA9|Q5LJA9_HUMAN;tr|H0Y6Y4|H0Y6Y4_HUMAN;tr|H0Y4E0|H0Y4E0_HUMAN",5354,"Q9Y5K5","UCHL5_HUMAN","Ubiquitin carboxyl-terminal hydrolase isozyme L5","CH-L5","UCHL5"]
["16.8943","15.046","16.6907",1,1,1,{"$nulls":3},"cardiac right ventricle formation;chromatin remodeling;covalent chromatin modification;muscle cell differentiation;neural retina development;nucleosome disassembly;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of neuroblast proliferation;positive regulation of smooth muscle cell differentiation;positive regulation of transcription, DNA-templated;regulation of lipid metabolic process;regulation of protein binding;regulation of transcription from RNA polymerase II promoter;secondary heart field specification;transcription, DNA-templated","chromatin binding;ligand-dependent nuclear receptor binding;ligand-dependent nuclear receptor transcription coactivator activity;nuclear hormone receptor binding;receptor binding;transcription coactivator activity;transcription factor binding","cytoplasm;nBAF complex;npBAF complex;nuclear chromatin;nucleoplasm;nucleus;SWI/SNF complex","Hepatocellular carcinoma;Thermogenesis",null,null,9,3,3,"20.3","7.9","7.9","55.015","0.00042535","4.77",44179000,0,"4.88571",1,"15.2103","25.9954","sp|Q6STE5|SMRD3_HUMAN","sp|Q6STE5|SMRD3_HUMAN",3050,"Q6STE5","SMRD3_HUMAN","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3",null,"SMARCD3"]
["15.5509","15.868","15.7321",1,1,1,{"$nulls":3},"activation of GTPase activity;intracellular protein transport;regulation of vesicle fusion","14-3-3 protein binding;GTPase activator activity;Rab GTPase binding","endomembrane system;intracellular",{"$nulls":3},1,1,1,"2.6","2.6","2.6","59.08","0.0011816","3.3252",12811000,2,"8.04107",1,"14.717","160.243","sp|Q9NU19|TB22B_HUMAN","sp|Q9NU19|TB22B_HUMAN",4726,"Q9NU19","TB22B_HUMAN","TBC1 domain family member 22B",null,"TBC1D22B"]
["16.106","13.7311","16.892",1,1,1,{"$nulls":4},"metal ion binding;RNA binding","nuclear speck;protein complex",{"$nulls":3},6,6,6,"11.1","11.1","11.1","106.38",0,"17.276",53208000,14,"3.97752",1,"14.5764","15.3415","sp|Q86VM9|ZCH18_HUMAN;tr|E7ERS3|E7ERS3_HUMAN;tr|H3BRH3|H3BRH3_HUMAN","sp|Q86VM9|ZCH18_HUMAN;tr|E7ERS3|E7ERS3_HUMAN",3231,"Q86VM9","ZCH18_HUMAN","Zinc finger CCCH domain-containing protein 18",null,"ZC3H18"]
["22.1941","18.8217","18.9338",1,"14.851",1,{"$nulls":5},"endosome;mitochondrial inner membrane",{"$nulls":3},5,5,5,"32.5","32.5","32.5","16.953",0,"21.611",84429000,11,"1.40967",1,"14.3662","3.02598","sp|Q56VL3|OCAD2_HUMAN;tr|D6RD77|D6RD77_HUMAN;tr|J3KPI9|J3KPI9_HUMAN","sp|Q56VL3|OCAD2_HUMAN",2796,"Q56VL3","OCAD2_HUMAN","OCIA domain-containing protein 2",null,"OCIAD2"]
["19.6269","21.4267","17.4532",1,"14.9105",1,{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of cysteine-type endopeptidase activity;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;nucleoplasm;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex;spermatoproteasome complex","Proteasome",null,null,4,4,4,"24.2","24.2","24.2","23.264",0,"9.2192",65397000,5,"1.35649",1,"13.8655","2.90255","sp|P28065|PSB9_HUMAN;tr|A2ACR1|A2ACR1_HUMAN;tr|A0A0G2JJA7|A0A0G2JJA7_HUMAN;tr|A2ACR0|A2ACR0_HUMAN;tr|A0A0G2JJQ0|A0A0G2JJQ0_HUMAN;tr|A0A0G2JJ13|A0A0G2JJ13_HUMAN;tr|A0A0G2JHI2|A0A0G2JHI2_HUMAN","sp|P28065|PSB9_HUMAN;tr|A2ACR1|A2ACR1_HUMAN;tr|A0A0G2JJA7|A0A0G2JJA7_HUMAN",1332,"P28065","PSB9_HUMAN","Proteasome subunit beta type-9",null,"PSMB9"]
["18.7044","18.8283","18.3889","17.0607","12.5616","14.8842",{"$nulls":5},"cytoskeleton",{"$nulls":3},18,18,18,"13.1","13.1","13.1","204.49",0,"78.548",375690000,31,"1.36169",1,"3.80508","2.9145","tr|K7EKI8|K7EKI8_HUMAN;sp|O60437|PEPL_HUMAN;tr|K7EQ71|K7EQ71_HUMAN","tr|K7EKI8|K7EKI8_HUMAN;sp|O60437|PEPL_HUMAN;tr|K7EQ71|K7EQ71_HUMAN",493,"K7EKI8","K7EKI8_HUMAN",null,null,"PPL"]
["20.2042","18.9195","19.8764","17.1129","16.79","17.1493",{"$nulls":3},"apoptotic DNA fragmentation;DNA metabolic process;erythrocyte differentiation","deoxyribonuclease II activity;DNA binding","extracellular exosome;intracellular;lysosome","Lysosome",null,null,4,4,4,"17.5","17.5","17.5","39.58",0,"9.0516",64232000,6,"2.56162",1,"2.64931","6.59139","sp|O00115|DNS2A_HUMAN;tr|K7ENE5|K7ENE5_HUMAN","sp|O00115|DNS2A_HUMAN;tr|K7ENE5|K7ENE5_HUMAN",198,"O00115","DNS2A_HUMAN","Deoxyribonuclease-2-alpha",null,"DNASE2"]
["21.5709","20.9526","21.2066","19.0589","18.4936","18.8804",{"$nulls":3},"chromatin silencing;covalent chromatin modification;dosage compensation;establishment of protein localization to chromatin;negative regulation of cell cycle G2/M phase transition;negative regulation of gene expression, epigenetic;negative regulation of histone H3-K27 methylation;negative regulation of histone H3-K4 methylation;negative regulation of histone phosphorylation;negative regulation of protein localization to chromosome, telomeric region;negative regulation of protein serine/threonine kinase activity;negative regulation of response to oxidative stress;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;nucleosome assembly;positive regulation of gene expression, epigenetic;positive regulation of keratinocyte differentiation;positive regulation of maintenance of mitotic sister chromatid cohesion;positive regulation of response to oxidative stress;regulation of gene expression, epigenetic;regulation of lipid metabolic process;regulation of response to oxidative stress","chromatin DNA binding;core promoter sequence-specific DNA binding;DNA binding;double-stranded methylated DNA binding;enzyme binding;nucleosomal DNA binding;protein heterodimerization activity;protein kinase binding;protein serine/threonine kinase inhibitor activity;rDNA binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription regulatory region DNA binding","Barr body;condensed chromosome;extracellular exosome;nuclear chromatin;nuclear chromosome;nuclear chromosome, telomeric region;nucleolus;nucleosome;nucleus;pericentric heterochromatin;sex chromatin","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,12,12,10,43,43,36,"39.617",0,"80.332",872350000,108,"3.23787",1,"2.43237","9.92656","sp|O75367|H2AY_HUMAN;tr|B4DJC3|B4DJC3_HUMAN;tr|D6RCF2|D6RCF2_HUMAN","sp|O75367|H2AY_HUMAN;tr|B4DJC3|B4DJC3_HUMAN",573,"O75367","H2AY_HUMAN","Core histone macro-H2A.1","H2A1;istone macroH2A1","H2AFY"]
["29.9701","28.5271","28.2377","27.0452","26.3196","26.5838",{"$nulls":3},"chromatin silencing","DNA binding;protein heterodimerization activity","extracellular exosome;nuclear chromatin;nucleosome;nucleus","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,6,6,1,55,55,"22.5","13.988",0,"188.2",51158000000,334,"1.76541",1,"2.26211","3.92586","sp|Q16777|H2A2C_HUMAN;sp|Q6FI13|H2A2A_HUMAN;sp|Q96QV6|H2A1A_HUMAN;REV__tr|H0Y672|H0Y672_HUMAN;REV__tr|E7EQ67|E7EQ67_HUMAN;REV__tr|H7BY63|H7BY63_HUMAN","sp|Q16777|H2A2C_HUMAN;sp|Q6FI13|H2A2A_HUMAN;sp|Q96QV6|H2A1A_HUMAN",2695,"Q16777","H2A2C_HUMAN","Histone H2A type 2-C",null,"HIST2H2AC"]
["16.5227","17.4276","17.3052","15.5019","14.1477","15.1272",{"$nulls":3},"attachment of mitotic spindle microtubules to kinetochore;protein localization to kinetochore;protein localization to microtubule;sister chromatid biorientation","metal ion binding;nucleic acid binding","condensed chromosome;condensed chromosome kinetochore;cytoplasm;nuclear body;nucleoplasm;nucleus;spindle",{"$nulls":3},11,11,11,17,17,17,"89.098",0,"35.168",255950000,30,"1.92466",1,"2.15956","4.37792","sp|Q96JM3|CHAP1_HUMAN;tr|S4R3K0|S4R3K0_HUMAN","sp|Q96JM3|CHAP1_HUMAN",3942,"Q96JM3","CHAP1_HUMAN","Chromosome alignment-maintaining phosphoprotein 1",null,"CHAMP1"]
["16.1038","15.9296","15.4397","13.0548","13.2968","14.7233",{"$nulls":3},"angiogenesis","ATPase activity;metal ion binding;ubiquitin-protein transferase activity","cytosol;nucleolus",{"$nulls":3},17,17,17,"4.2","4.2","4.2","591.4",0,"36.197",130050000,22,"1.72915",1,"2.13275","3.82754","tr|A0A0A0MTR7|A0A0A0MTR7_HUMAN;sp|Q63HN8|RN213_HUMAN;tr|A0A0A0MTC1|A0A0A0MTC1_HUMAN","tr|A0A0A0MTR7|A0A0A0MTR7_HUMAN;sp|Q63HN8|RN213_HUMAN;tr|A0A0A0MTC1|A0A0A0MTC1_HUMAN",2919,"A0A0A0MTR7","A0A0A0MTR7_HUMAN",null,null,"RNF213"]
["21.0356","20.3317","20.9655","19.2652","18.827","17.9451",{"$nulls":3},"cell cycle;nucleobase-containing compound metabolic process;positive regulation of Notch signaling pathway;pyrimidine nucleoside metabolic process;pyrimidine nucleotide biosynthetic process","methyl-CpG binding;RNA binding","methylosome;midbody",{"$nulls":3},2,2,2,"21.2","21.2","21.2","12.259",0,"8.1375",64522000,5,"2.02559",1,"2.09849","4.68282","sp|P84090|ERH_HUMAN;tr|G3V279|G3V279_HUMAN","sp|P84090|ERH_HUMAN;tr|G3V279|G3V279_HUMAN",2097,"P84090","ERH_HUMAN","Enhancer of rudimentary homolog",null,"ERH"]
["19.9136","19.9034","18.683","16.9153","16.9164","18.5113",{"$nulls":3},"bone development;chaperone-mediated protein folding;collagen metabolic process;negative regulation of cell proliferation;negative regulation of post-translational protein modification;protein folding;protein hydroxylation;protein stabilization;regulation of protein secretion","iron ion binding;L-ascorbic acid binding;procollagen-proline 3-dioxygenase activity;protein complex binding","endoplasmic reticulum;endoplasmic reticulum lumen;extracellular exosome;macromolecular complex;membrane;proteinaceous extracellular matrix",{"$nulls":3},7,7,7,"10.7","10.7","10.7","83.393",0,"25.186",145440000,14,"1.42428",1,"2.05231","3.06035","sp|Q32P28|P3H1_HUMAN;tr|H7C2W6|H7C2W6_HUMAN;tr|E2QRI1|E2QRI1_HUMAN","sp|Q32P28|P3H1_HUMAN",2731,"Q32P28","P3H1_HUMAN","Prolyl 3-hydroxylase 1 {ECO:0000312|HGNC:HGNC:19316}",null,"P3H1"]
["25.1622","23.4127","23.0095","22.0897","21.4292","21.9412",{"$nulls":3},"macroautophagy;protein import into mitochondrial matrix;protein import into mitochondrial outer membrane;protein targeting to mitochondrion","protein transmembrane transporter activity","integral component of membrane;integral component of mitochondrial outer membrane;membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrial outer membrane translocase complex",{"$nulls":3},6,6,6,"66.2","66.2","66.2","15.521",0,"158.69",579480000,44,"1.38015",1,"2.04145","2.95715","sp|Q9NS69|TOM22_HUMAN","sp|Q9NS69|TOM22_HUMAN",4708,"Q9NS69","TOM22_HUMAN","Mitochondrial import receptor subunit TOM22 homolog","Tom22","TOMM22"]
["28.7408","28.5397","28.3186","26.8564","26.3343","26.7021",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular protein metabolic process;CENP-A containing nucleosome assembly;chromatin silencing at rDNA;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;DNA-templated transcription, initiation;double-strand break repair via nonhomologous end joining;negative regulation of gene expression, epigenetic;negative regulation of megakaryocyte differentiation;nucleosome assembly;positive regulation of gene expression, epigenetic;protein heterotetramerization;regulation of gene silencing by miRNA;regulation of hematopoietic stem cell differentiation;regulation of megakaryocyte differentiation;telomere capping;telomere organization","DNA binding;histone binding;protein domain specific binding;protein heterodimerization activity;RNA binding","extracellular exosome;extracellular matrix;extracellular region;membrane;nuclear chromosome;nuclear chromosome, telomeric region;nuclear nucleosome;nucleoplasm;nucleosome;nucleus;protein complex","Alcoholism;Systemic lupus erythematosus;Viral carcinogenesis",null,null,12,12,12,66,66,66,"11.367",0,"98.526",34093000000,508,"3.19041",1,"1.90208","9.64988","sp|P62805|H4_HUMAN","sp|P62805|H4_HUMAN",1991,"P62805","H4_HUMAN","Histone H4",null,"HIST1H4A;HIST1H4B;HIST1H4C;HIST1H4D;HIST1H4E;HIST1H4F;HIST1H4H;HIST1H4I;HIST1H4J;HIST1H4K;HIST1H4L;HIST2H4A;HIST2H4B;HIST4H4"]
["20.3483","19.4532","20.0188","17.8398","17.986","19.1184",{"$nulls":9},4,4,4,"16.6","16.6","16.6","34.815",0,"6.6373",91629000,7,"1.55523",1,"1.62537","3.37762","tr|Q9UFM8|Q9UFM8_HUMAN;sp|Q9Y639|NPTN_HUMAN;tr|H3BU51|H3BU51_HUMAN;tr|H3BQ94|H3BQ94_HUMAN","tr|Q9UFM8|Q9UFM8_HUMAN;sp|Q9Y639|NPTN_HUMAN;tr|H3BU51|H3BU51_HUMAN",5387,"Q9UFM8","Q9UFM8_HUMAN",null,null,"DKFZp566H1924"]
["20.9725","20.1672","20.3694","19.4266","18.0253","19.1897",{"$nulls":3},"hemidesmosome assembly","actin binding;ankyrin binding;cadherin binding;RNA binding;structural constituent of muscle","brush border;costamere;cytosol;extracellular exosome;extracellular matrix;focal adhesion;hemidesmosome;intermediate filament cytoskeleton;plasma membrane;sarcolemma;sarcoplasm",{"$nulls":3},133,133,131,"38.5","38.5","37.8","531.78",0,"323.31",3428400000,308,"1.51201",1,"1.62249","3.27101","sp|Q15149|PLEC_HUMAN;tr|E9PMV1|E9PMV1_HUMAN;tr|H0YDN1|H0YDN1_HUMAN;tr|E9PKG0|E9PKG0_HUMAN;tr|E9PQ28|E9PQ28_HUMAN;tr|E9PIA2|E9PIA2_HUMAN","sp|Q15149|PLEC_HUMAN",2565,"Q15149","PLEC_HUMAN","Plectin","CN;LTN","PLEC"]
["20.9074","20.3892","19.9884","19.699","18.2953","18.5612",{"$nulls":3},"cell differentiation;multicellular organism development;negative regulation of transcription, DNA-templated","transcription corepressor activity","cytosol;microtubule;nucleus",{"$nulls":3},14,14,14,"23.8","23.8","23.8","80.642",0,"54.689",445070000,49,"1.44755",1,"1.57652","3.11549","sp|Q96AQ6|PBIP1_HUMAN;tr|F2Z2Z8|F2Z2Z8_HUMAN;tr|Q5T173|Q5T173_HUMAN","sp|Q96AQ6|PBIP1_HUMAN",3793,"Q96AQ6","PBIP1_HUMAN","Pre-B-cell leukemia transcription factor-interacting protein 1",null,"PBXIP1"]
["24.9014","24.5203","24.1279","22.763","22.987","23.1018",{"$nulls":3},"angiogenesis;angiotensin-activated signaling pathway involved in heart process;apoptotic signaling pathway;beta-catenin destruction complex disassembly;calcium ion homeostasis;calcium ion transport;caveola assembly;caveolin-mediated endocytosis;cellular calcium ion homeostasis;cellular response to exogenous dsRNA;cellular response to hyperoxia;cellular response to peptide hormone stimulus;cellular response to starvation;cellular response to transforming growth factor beta stimulus;cholesterol homeostasis;cholesterol transport;inactivation of MAPK activity;lactation;leukocyte migration;lipid storage;maintenance of protein location in cell;mammary gland development;mammary gland involution;membrane depolarization;negative regulation of anoikis;negative regulation of BMP signaling pathway;negative regulation of canonical Wnt signaling pathway;negative regulation of cytokine-mediated signaling pathway;negative regulation of endothelial cell proliferation;negative regulation of epithelial cell differentiation;negative regulation of inward rectifier potassium channel activity;negative regulation of JAK-STAT cascade;negative regulation of MAPK cascade;negative regulation of necroptotic process;negative regulation of nitric oxide biosynthetic process;negative regulation of nitric-oxide synthase activity;negative regulation of peptidyl-serine phosphorylation;negative regulation of peptidyl-tyrosine autophosphorylation;negative regulation of pinocytosis;negative regulation of potassium ion transmembrane transport;negative regulation of protein binding;negative regulation of protein tyrosine kinase activity;negative regulation of protein ubiquitination;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transforming growth factor beta receptor signaling pathway;negative regulation of tyrosine phosphorylation of STAT protein;nitric oxide homeostasis;positive regulation of calcium ion transport into cytosol;positive regulation of canonical Wnt signaling pathway;positive regulation of catalytic activity;positive regulation of cell adhesion molecule production;positive regulation of ER-associated ubiquitin-dependent protein catabolic process;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of gap junction assembly;positive regulation of gene expression;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein binding;positive regulation of protein ubiquitination;positive regulation of toll-like receptor 3 signaling pathway;positive regulation of vasoconstriction;posttranscriptional regulation of gene expression;protein homooligomerization;protein localization;protein localization to basolateral plasma membrane;protein localization to plasma membrane raft;receptor internalization;receptor internalization involved in canonical Wnt signaling pathway;receptor-mediated endocytosis of virus by host cell;regulation of blood coagulation;regulation of cardiac muscle cell action potential involved in regulation of contraction;regulation of cell communication by electrical coupling involved in cardiac conduction;regulation of cytosolic calcium ion concentration;regulation of entry of bacterium into host cell;regulation of fatty acid metabolic process;regulation of heart rate by cardiac conduction;regulation of membrane repolarization during action potential;regulation of nitric-oxide synthase activity;regulation of peptidase activity;regulation of ruffle assembly;regulation of smooth muscle contraction;regulation of the force of heart contraction by chemical signal;regulation of ventricular cardiac muscle cell action potential;response to bacterium;response to calcium ion;response to estrogen;response to hypoxia;response to ischemia;response to progesterone;skeletal muscle tissue development;T cell costimulation;triglyceride metabolic process;vasculogenesis;vasoconstriction;vesicle organization","ATPase binding;cholesterol binding;enzyme binding;identical protein binding;inward rectifier potassium channel inhibitor activity;ion channel binding;nitric-oxide synthase binding;patched binding;peptidase activator activity;protein binding, bridging;protein complex scaffold activity;protein heterodimerization activity;protein kinase binding;Rac GTPase binding;receptor binding;structural molecule activity","acrosomal membrane;apical plasma membrane;basolateral plasma membrane;caveola;cell cortex;cilium;cytoplasmic vesicle;early endosome membrane;endocytic vesicle membrane;endoplasmic reticulum;endoplasmic reticulum membrane;endosome;focal adhesion;Golgi membrane;integral component of plasma membrane;intracellular;lipid droplet;membrane;membrane raft;perinuclear region of cytoplasm;plasma membrane;protein complex","Bacterial invasion of epithelial cells;Endocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;Proteoglycans in cancer;Viral myocarditis",null,null,4,4,2,"30.3","30.3","12.9","20.471",0,"51.606",1415400000,35,"2.5155",1,"1.56592","6.4054","sp|Q03135|CAV1_HUMAN;tr|E9PCT5|E9PCT5_HUMAN;sp|P56539|CAV3_HUMAN","sp|Q03135|CAV1_HUMAN;tr|E9PCT5|E9PCT5_HUMAN",2172,"Q03135","CAV1_HUMAN","Caveolin-1",null,"CAV1"]
["19.9606","18.9266","19.0488","17.5427","17.6277","18.1538",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;RNA splicing;RNA splicing, via transesterification reactions;spliceosomal tri-snRNP complex assembly","identical protein binding;RNA binding","Cajal body;cytosol;nuclear speck;nucleoplasm;nucleus;protein complex;spliceosomal complex;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,15,15,15,"32.8","32.8","32.8","77.528",0,"45.827",549150000,62,"1.81613",1,"1.53726","4.06616","sp|O43395|PRPF3_HUMAN","sp|O43395|PRPF3_HUMAN",414,"O43395","PRPF3_HUMAN","U4/U6 small nuclear ribonucleoprotein Prp3",null,"PRPF3"]
["21.2716","20.0667","20.5082","19.4322","18.5204","19.3589",{"$nulls":9},17,14,14,"31.6","28.5","28.5","69.948",0,"43.45",501540000,46,"1.52526",1,"1.51169","3.30347","tr|J9JID7|J9JID7_HUMAN;sp|Q03252|LMNB2_HUMAN","tr|J9JID7|J9JID7_HUMAN;sp|Q03252|LMNB2_HUMAN",2175,"Q03252",{"$nulls":3},"LMNB2"]
["20.1577","19.6639","20.0922","18.6677","18.6575","18.0562",{"$nulls":3},"cell-cell signaling;cellular protein metabolic process;constitutive protein ectodomain proteolysis;extracellular matrix disassembly;in utero embryonic development;integrin-mediated signaling pathway;membrane protein ectodomain proteolysis;monocyte activation;negative regulation of cell adhesion;neutrophil degranulation;Notch receptor processing;Notch signaling pathway;PMA-inducible membrane protein ectodomain proteolysis;positive regulation of cell growth;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of T cell chemotaxis;post-translational protein modification;protein phosphorylation;protein processing;response to tumor necrosis factor","endopeptidase activity;integrin binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;protein homodimerization activity;protein kinase binding;receptor binding;SH3 domain binding","cell surface;cytoplasm;endoplasmic reticulum lumen;extracellular exosome;focal adhesion;Golgi apparatus;Golgi membrane;Golgi-associated vesicle;integral component of membrane;membrane;nucleus;perinuclear endoplasmic reticulum;plasma membrane;postsynaptic density;specific granule membrane;tertiary granule membrane;tetraspanin-enriched microdomain","Alzheimer disease;Epithelial cell signaling in Helicobacter pylori infection",null,null,12,12,12,"22.9","22.9","22.9","84.141",0,"38.81",300270000,30,"2.39306",1,"1.51082","5.93312","sp|O14672|ADA10_HUMAN;tr|H3BS53|H3BS53_HUMAN;tr|H0YNC5|H0YNC5_HUMAN","sp|O14672|ADA10_HUMAN",284,"O14672","ADA10_HUMAN","Disintegrin and metalloproteinase domain-containing protein 10","DAM 10","ADAM10"]
["22.7216","21.7816","22.2094","20.8074","20.0668","21.3504",{"$nulls":4},"RNA binding;zinc ion binding",{"$nulls":4},7,7,6,"42.3","42.3","42.3","15.763",0,"21.202",380610000,25,"1.50242",1,"1.49602","3.24759","tr|A0A0B4J1Z1|A0A0B4J1Z1_HUMAN;tr|C9JAB2|C9JAB2_HUMAN;sp|Q16629|SRSF7_HUMAN","tr|A0A0B4J1Z1|A0A0B4J1Z1_HUMAN;tr|C9JAB2|C9JAB2_HUMAN;sp|Q16629|SRSF7_HUMAN",2679,"A0A0B4J1Z1","A0A0B4J1Z1_HUMAN",null,null,"SRSF7"]
["19.3568","18.3645","18.7871","17.2962","17.4266","17.2997",{"$nulls":4},"oxidoreductase activity",{"$nulls":4},10,10,10,"16.2","16.2","16.2","88.569",0,"23.238",174430000,14,"2.16922",1,"1.49532","5.14388","tr|A8MT40|A8MT40_HUMAN;sp|Q8NCN5|PDPR_HUMAN;tr|B7ZAR9|B7ZAR9_HUMAN;tr|H3BQG3|H3BQG3_HUMAN;tr|H3BUH3|H3BUH3_HUMAN","tr|A8MT40|A8MT40_HUMAN;sp|Q8NCN5|PDPR_HUMAN",3474,"A8MT40","A8MT40_HUMAN",null,null,"PDPR"]
["21.3118","20.981","20.8362","19.7212","19.2069","19.7974",{"$nulls":3},"cellular response to interleukin-1;membrane protein ectodomain proteolysis;mRNA splice site selection;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;osteoblast differentiation;positive regulation of mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;protein homooligomerization;protein oligomerization;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;transcription from RNA polymerase II promoter","chromatin binding;core promoter binding;identical protein binding;mRNA binding;protein domain specific binding;RNA binding;single-stranded RNA binding","catalytic step 2 spliceosome;extracellular exosome;extracellular space;intracellular ribonucleoprotein complex;membrane;nuclear euchromatin;nucleoplasm;nucleus;supraspliceosomal complex","Spliceosome",null,null,6,6,6,"17.1","17.1","17.1","42.331",0,"48.361",330240000,18,"2.49016",1,"1.46785","6.30514","sp|P38159|RBMX_HUMAN;tr|H0Y6E7|H0Y6E7_HUMAN;tr|H3BT71|H3BT71_HUMAN;tr|H3BR27|H3BR27_HUMAN;sp|Q96E39|RMXL1_HUMAN;tr|H3BNC1|H3BNC1_HUMAN;tr|H3BUY5|H3BUY5_HUMAN;sp|O75526|RMXL2_HUMAN;sp|Q8N7X1|RMXL3_HUMAN","sp|P38159|RBMX_HUMAN;tr|H0Y6E7|H0Y6E7_HUMAN;tr|H3BT71|H3BT71_HUMAN;tr|H3BR27|H3BR27_HUMAN;sp|Q96E39|RMXL1_HUMAN",1500,"P38159","RBMX_HUMAN","RNA-binding motif protein, X chromosome",null,"RBMX"]
["20.8164","20.1462","21.3831","19.1519","19.129","19.6983",{"$nulls":5},"fibrillar center;intracellular membrane-bounded organelle",{"$nulls":3},3,3,3,"19.1","19.1","19.1","32.57",0,"15.103",123550000,10,"1.64732",1,"1.45551","3.61153","tr|A0A0A0MT32|A0A0A0MT32_HUMAN;sp|P38571|LICH_HUMAN;tr|Q5T073|Q5T073_HUMAN;tr|Q5T770|Q5T770_HUMAN","tr|A0A0A0MT32|A0A0A0MT32_HUMAN;sp|P38571|LICH_HUMAN;tr|Q5T073|Q5T073_HUMAN",1502,"A0A0A0MT32","A0A0A0MT32_HUMAN",null,null,"LIPA"]
["27.4147","28.0561","27.7597","26.0826","26.5846","26.296",{"$nulls":4},"DNA binding;protein heterodimerization activity","nucleosome;nucleus",{"$nulls":3},5,5,1,47,47,"24.2","14.914",0,"179.58",15071000000,138,"2.42066",1,"1.42242","6.03694","tr|K7EK07|K7EK07_HUMAN;sp|P84243|H33_HUMAN","tr|K7EK07|K7EK07_HUMAN;sp|P84243|H33_HUMAN",2101,"K7EK07","K7EK07_HUMAN","Histone H3 {ECO:0000256|RuleBase:RU004471}",null,"H3F3B"]
["23.3335","22.8143","23.4875","22.0461","21.4605","21.9365",{"$nulls":3},"base-excision repair;cell division;chondrocyte differentiation;chondrocyte proliferation;chromatin organization;chromosome breakage;chromosome condensation;DNA damage response, detection of DNA damage;endodermal cell differentiation;epithelial to mesenchymal transition;fat cell differentiation;heterochromatin assembly;histone H2A-S139 phosphorylation;mesenchymal cell differentiation;mesodermal cell differentiation;mesodermal-endodermal cell signaling;mitotic G2 DNA damage checkpoint;multicellular organism development;negative regulation by host of viral transcription;negative regulation of apoptotic process;negative regulation of cellular senescence;negative regulation of DNA binding;negative regulation of double-strand break repair via nonhomologous end joining;negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;oncogene-induced cell senescence;positive regulation of angiogenesis;positive regulation of apoptotic process;positive regulation of cell cycle arrest;positive regulation of cell proliferation in bone marrow;positive regulation of cellular response to X-ray;positive regulation of cellular senescence;positive regulation of gene expression;positive regulation of response to DNA damage stimulus;positive regulation of stem cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription regulatory region DNA binding;positive regulation of transcription, DNA-templated;regulation of cell cycle process;regulation of cellular response to drug;regulation of growth;regulation of stem cell population maintenance;regulation of transcription, DNA-templated;response to virus;senescence-associated heterochromatin focus assembly;stem cell differentiation","5'-deoxyribose-5-phosphate lyase activity;AT DNA binding;C2H2 zinc finger domain binding;cAMP response element binding;core promoter binding;DNA binding;DNA binding, bending;DNA-(apurinic or apyrimidinic site) lyase activity;DNA-dependent protein kinase activity;MH1 domain binding;MH2 domain binding;nucleosomal DNA binding;SMAD binding;transcription factor binding;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nuclear chromosome;nucleoplasm;nucleus;protein-DNA complex;senescence-associated heterochromatin focus;SMAD protein complex","MicroRNAs in cancer;Transcriptional misregulation in cancer",null,null,4,4,4,"56.9","56.9","56.9","11.832",0,"110.53",1106800000,66,"2.1695",1,"1.3974","5.14484","sp|P52926|HMGA2_HUMAN;tr|F5H2U8|F5H2U8_HUMAN;tr|F5H2A4|F5H2A4_HUMAN;tr|F5H6H0|F5H6H0_HUMAN","sp|P52926|HMGA2_HUMAN;tr|F5H2U8|F5H2U8_HUMAN;tr|F5H2A4|F5H2A4_HUMAN;tr|F5H6H0|F5H6H0_HUMAN",1786,"P52926","HMGA2_HUMAN","High mobility group protein HMGI-C",null,"HMGA2"]
["24.379","23.3403","23.6957","22.748","22.5225","22.1675",{"$nulls":3},"hemopoiesis;positive regulation of cell proliferation","zinc ion binding","cell cortex",{"$nulls":3},8,8,8,"53.8","53.8","53.8","22.492",0,"76.827",961270000,49,"1.7204",1,"1.32563","3.80407","sp|P52943|CRIP2_HUMAN;tr|H0YFA4|H0YFA4_HUMAN;tr|H0YHD8|H0YHD8_HUMAN","sp|P52943|CRIP2_HUMAN;tr|H0YFA4|H0YFA4_HUMAN;tr|H0YHD8|H0YHD8_HUMAN",1787,"P52943","CRIP2_HUMAN","Cysteine-rich protein 2","RP-2","CRIP2"]
["20.659","20.6681","20.7882","19.2887","20.0478","18.8248",{"$nulls":3},"box H/ACA snoRNA 3'-end processing;cell proliferation;mRNA pseudouridine synthesis;positive regulation of establishment of protein localization to telomere;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;regulation of telomerase RNA localization to Cajal body;RNA processing;rRNA processing;rRNA pseudouridine synthesis;snRNA pseudouridine synthesis;telomerase RNA stabilization;telomere maintenance via telomerase","box H/ACA snoRNA binding;pseudouridine synthase activity;RNA binding;telomerase activity;telomerase RNA binding","box H/ACA scaRNP complex;box H/ACA snoRNP complex;box H/ACA telomerase RNP complex;cytoplasm;fibrillar center;nucleolus;nucleoplasm;nucleus;telomerase holoenzyme complex","Ribosome biogenesis in eukaryotes",null,null,18,18,18,"40.1","40.1","40.1","57.673",0,"71.446",1115300000,97,"1.6707",1,"1.31801","3.67244","sp|O60832|DKC1_HUMAN;tr|C9IYT0|C9IYT0_HUMAN;tr|H7C0M1|H7C0M1_HUMAN;tr|H7C2Q9|H7C2Q9_HUMAN;tr|H7BZF2|H7BZF2_HUMAN;tr|H7C2Q2|H7C2Q2_HUMAN","sp|O60832|DKC1_HUMAN;tr|C9IYT0|C9IYT0_HUMAN;tr|H7C0M1|H7C0M1_HUMAN",529,"O60832","DKC1_HUMAN","H/ACA ribonucleoprotein complex subunit 4",null,"DKC1"]
["16.1868","16.3452","16.5014","15.0869","15.6651","14.3364",{"$nulls":3},"benzylpenicillin metabolic process;canalicular bile acid transport;cellular chloride ion homeostasis;cellular response to dexamethasone stimulus;cellular response to hormone stimulus;cellular response to interleukin-1;cellular response to interleukin-6;cellular response to lipopolysaccharide;cellular response to tumor necrosis factor;drug transmembrane transport;female pregnancy;mercury ion transport;prostaglandin transport;response to antineoplastic agent;response to arsenic-containing substance;response to estrogen;response to glucagon;response to heat;response to methotrexate;response to oxidative stress;thyroid hormone transport;transmembrane transport;transport","ATP binding;ATPase activity, coupled to transmembrane movement of substances;ATPase-coupled anion transmembrane transporter activity;bilirubin transmembrane transporter activity;organic anion transmembrane transporter activity;protein domain specific binding","apical plasma membrane;brush border membrane;cell surface;integral component of plasma membrane;intercellular canaliculus;plasma membrane","ABC transporters;Antifolate resistance;Bile secretion;Platinum drug resistance",null,null,20,20,19,"16.6","16.6",16,"174.21",0,"66.435",573140000,67,"1.53489",1,"1.31495","3.32721","sp|Q92887|MRP2_HUMAN","sp|Q92887|MRP2_HUMAN",3730,"Q92887","MRP2_HUMAN","Canalicular multispecific organic anion transporter 1",null,"ABCC2"]
["20.5264","19.6031","20.2069","18.8557","18.6594","18.9001",{"$nulls":3},"chromatin organization;growth;hormone metabolic process;intracellular estrogen receptor signaling pathway;positive regulation of transcription from RNA polymerase II promoter;regulation of mRNA processing;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","chromatin binding;core promoter binding;double-stranded DNA binding;RNA binding;sequence-specific DNA binding","nucleoplasm;nucleus",{"$nulls":3},8,8,8,"13.6","13.6","13.6","102.64",0,"74.846",293220000,32,"2.01737",1,"1.30708","4.65744","sp|Q15424|SAFB1_HUMAN;sp|Q14151|SAFB2_HUMAN;tr|K7ES42|K7ES42_HUMAN","sp|Q15424|SAFB1_HUMAN;sp|Q14151|SAFB2_HUMAN",2600,"Q15424","SAFB1_HUMAN","Scaffold attachment factor B1","AF-B;AF-B1","SAFB"]
["22.7795","22.5755","23.225","21.4935","21.3177","21.9236",{"$nulls":3},"mRNA splicing, via spliceosome;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA processing","pre-mRNA intronic binding;RNA binding;transcription regulatory region DNA binding","cytoplasm;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus;ribonucleoprotein granule",{"$nulls":3},16,16,8,"41.6","41.6","24.4","64.132",0,"150.46",944940000,65,"2.08619",1,"1.28176","4.87334","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN;tr|M0R1W6|M0R1W6_HUMAN;tr|M0R076|M0R076_HUMAN;tr|M0QYL7|M0QYL7_HUMAN;tr|B4DVF8|B4DVF8_HUMAN","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN",1109,"P14866","HNRPL_HUMAN","Heterogeneous nuclear ribonucleoprotein L","nRNP L","HNRNPL"]
["25.1782","25.158","24.7143","24.2187","23.3265","23.7618",{"$nulls":3},"cellular protein localization;cellular response to hypoxia;establishment or maintenance of microtubule cytoskeleton polarity;IRE1-mediated unfolded protein response;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;muscle organ development;negative regulation of cardiac muscle hypertrophy in response to stress;negative regulation of cell proliferation;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of mesenchymal cell proliferation;negative regulation of release of cytochrome c from mitochondria;nuclear envelope organization;positive regulation of cell aging;protein localization to nucleus;regulation of cell migration;regulation of protein localization to nucleus;regulation of telomere maintenance;sterol regulatory element binding protein import into nucleus;ventricular cardiac muscle cell development","identical protein binding;structural molecule activity","cytosol;extracellular matrix;intermediate filament;lamin filament;nuclear envelope;nuclear lamina;nuclear membrane;nuclear speck;nucleoplasm;nucleus;perinuclear region of cytoplasm","Apoptosis;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM)",null,null,41,41,40,"58.6","58.6","58.6","74.139",0,"323.31",9549300000,366,"1.8553",1,"1.24783","4.17681","sp|P02545|LMNA_HUMAN;tr|Q3BDU5|Q3BDU5_HUMAN;tr|Q5TCI8|Q5TCI8_HUMAN;tr|H0YAB0|H0YAB0_HUMAN;tr|A0A0C4DGC5|A0A0C4DGC5_HUMAN","sp|P02545|LMNA_HUMAN;tr|Q3BDU5|Q3BDU5_HUMAN;tr|Q5TCI8|Q5TCI8_HUMAN",849,"P02545","LMNA_HUMAN","Prelamin-A/C",null,"LMNA"]
["23.0051","22.3344","22.0287","21.3083","20.8612","21.5274",{"$nulls":3},"ATP transport;cellular response to calcium ion;cellular response to oxidative stress;mitochondrial transport;regulation of cell death","ADP transmembrane transporter activity;ATP transmembrane transporter activity;calcium ion binding","integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},21,21,21,"51.8","51.8","51.8","53.354",0,"90.651",1027500000,82,"1.60775",1,"1.22377","3.50989","sp|Q6NUK1|SCMC1_HUMAN;tr|J3KN42|J3KN42_HUMAN;tr|H3BMI3|H3BMI3_HUMAN","sp|Q6NUK1|SCMC1_HUMAN",2977,"Q6NUK1","SCMC1_HUMAN","Calcium-binding mitochondrial carrier protein SCaMC-1",null,"SLC25A24"]
["19.7814","18.8441","19.354","18.644","17.7702","17.9416",{"$nulls":3},"signal transduction","GTPase activator activity","cytosol;nucleoplasm",{"$nulls":3},17,17,14,"22.1","22.1","19.7","120.74",0,"89.73",444230000,54,"1.47195",1,"1.20792","3.17387","tr|B7ZM87|B7ZM87_HUMAN;tr|A2RUF3|A2RUF3_HUMAN;sp|O75044|SRGP2_HUMAN;tr|A0A075B7B5|A0A075B7B5_HUMAN;sp|P0DMP2|SRG2B_HUMAN;sp|P0DJJ0|SRG2C_HUMAN;tr|Q5VZB4|Q5VZB4_HUMAN;tr|A0A075B743|A0A075B743_HUMAN;tr|A0A075B7E6|A0A075B7E6_HUMAN;tr|E9PDX4|E9PDX4_HUMAN;tr|A0A075B7E9|A0A075B7E9_HUMAN;tr|A0A087WW56|A0A087WW56_HUMAN;tr|A0A087X0L1|A0A087X0L1_HUMAN;tr|A0A087X1G6|A0A087X1G6_HUMAN","tr|B7ZM87|B7ZM87_HUMAN;tr|A2RUF3|A2RUF3_HUMAN;sp|O75044|SRGP2_HUMAN;tr|A0A075B7B5|A0A075B7B5_HUMAN",541,"O75044","B7ZM87_HUMAN",null,null,"SRGAP2"]
["21.0409","20.83","20.3557","20.0551","18.8716","19.6977",{"$nulls":3},"apoptotic process;cellular response to leukemia inhibitory factor;negative regulation of transcription, DNA-templated;positive regulation of apoptotic process;positive regulation of DNA-templated transcription, initiation;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of response to DNA damage stimulus;regulation of DNA-templated transcription in response to stress;transcription, DNA-templated","DNA binding;RNA binding","cytoplasm;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},14,13,13,"18.6","17.4","17.4","106.12",0,"74.251",561300000,58,"1.38405",1,"1.20075","2.96618","sp|Q9NYF8|BCLF1_HUMAN;tr|E9PK91|E9PK91_HUMAN;tr|E9PK09|E9PK09_HUMAN;tr|E9PQN2|E9PQN2_HUMAN;tr|E9PKI6|E9PKI6_HUMAN;tr|E9PJA7|E9PJA7_HUMAN;tr|H0YF14|H0YF14_HUMAN;tr|H0YF00|H0YF00_HUMAN;tr|H0YF63|H0YF63_HUMAN","sp|Q9NYF8|BCLF1_HUMAN;tr|E9PK91|E9PK91_HUMAN;tr|E9PK09|E9PK09_HUMAN;tr|E9PQN2|E9PQN2_HUMAN;tr|E9PKI6|E9PKI6_HUMAN;tr|E9PJA7|E9PJA7_HUMAN",4850,"Q9NYF8","BCLF1_HUMAN","Bcl-2-associated transcription factor 1","tf","BCLAF1"]
["22.184","21.6439","21.0629","20.9353","20.08","20.2741",{"$nulls":3},"mRNA 3'-splice site recognition;mRNA processing;mRNA splicing, via spliceosome;positive regulation of neuron projection development;RNA splicing","RNA binding;zinc ion binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;small nuclear ribonucleoprotein complex;spliceosomal complex;U2 snRNP;U2-type prespliceosome","Spliceosome",null,null,7,7,7,"21.1","21.1","21.1","49.255",0,"36.445",360100000,26,"1.35373",1,"1.20045","2.89621","sp|Q15428|SF3A2_HUMAN;tr|K7EMT0|K7EMT0_HUMAN","sp|Q15428|SF3A2_HUMAN",2602,"Q15428","SF3A2_HUMAN","Splicing factor 3A subunit 2",null,"SF3A2"]
["20.5906","21.006","20.9192","19.7415","19.9239","19.2618",{"$nulls":3},"anastral spindle assembly;astral microtubule organization;cell division;chromosome segregation;establishment of mitotic spindle orientation;meiotic cell cycle;microtubule bundle formation;nucleus organization;positive regulation of BMP signaling pathway;positive regulation of chromosome segregation;positive regulation of chromosome separation;positive regulation of hair follicle development;positive regulation of intracellular transport;positive regulation of keratinocyte differentiation;positive regulation of microtubule polymerization;positive regulation of mitotic spindle elongation;positive regulation of protein localization to cell cortex;positive regulation of protein localization to spindle pole body;positive regulation of spindle assembly;regulation of metaphase plate congression;regulation of mitotic spindle organization","disordered domain specific binding;dynein complex binding;microtubule binding;microtubule minus-end binding;microtubule plus-end binding;phosphatidylinositol binding;protein complex binding;protein C-terminus binding;protein domain specific binding;structural molecule activity;tubulin binding","cell cortex;cell cortex region;centrosome;chromosome;cortical microtubule;cytoplasmic microtubule bundle;cytosol;dendrite;extracellular exosome;extrinsic component of plasma membrane;Golgi membrane;lateral cell cortex;lateral plasma membrane;microtubule bundle;microtubule minus-end;microtubule plus-end;mitotic spindle;mitotic spindle astral microtubule;mitotic spindle midzone;mitotic spindle pole;neuronal cell body;nuclear matrix;nucleoplasm;nucleus;protein complex;spindle;spindle microtubule;spindle pole;spindle pole centrosome",{"$nulls":3},61,61,61,"41.2","41.2","41.2","238.26",0,"323.31",2539400000,259,"2.15635",1,"1.19619","5.10122","sp|Q14980|NUMA1_HUMAN;tr|A0A087WY61|A0A087WY61_HUMAN;tr|H0YFY6|H0YFY6_HUMAN;tr|F5H4J1|F5H4J1_HUMAN;tr|F5H6Y5|F5H6Y5_HUMAN;tr|K4DIE0|K4DIE0_HUMAN;tr|F5H763|F5H763_HUMAN;tr|F5H0Z7|F5H0Z7_HUMAN;tr|F5H2F3|F5H2F3_HUMAN;tr|F5H3L6|F5H3L6_HUMAN;tr|F5H1L0|F5H1L0_HUMAN;tr|F5GZW1|F5GZW1_HUMAN;tr|F5H7R5|F5H7R5_HUMAN;tr|F5H4Y4|F5H4Y4_HUMAN;tr|F5GWA2|F5GWA2_HUMAN;tr|F5GWK2|F5GWK2_HUMAN;tr|F5H073|F5H073_HUMAN;tr|F5H068|F5H068_HUMAN;tr|F8W6T3|F8W6T3_HUMAN","sp|Q14980|NUMA1_HUMAN;tr|A0A087WY61|A0A087WY61_HUMAN",2520,"Q14980","NUMA1_HUMAN","Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}",null,"NUMA1"]
["20.4559","19.7112","20.0856","18.3088","19.1551","19.2686",{"$nulls":3},"cellular response to stimulus;oligodendrocyte development;regulation of molecular function;response to glucose;response to heat;response to peptide hormone;translational initiation","identical protein binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex;membrane;plasma membrane","Herpes simplex virus 1 infection;RNA transport",null,null,12,12,12,"44.9","44.9","44.9","33.712",0,"34.987",288450000,38,"1.46614",1,"1.17341","3.15991","sp|Q14232|EI2BA_HUMAN;tr|F5H0D0|F5H0D0_HUMAN;tr|H0YGG4|H0YGG4_HUMAN","sp|Q14232|EI2BA_HUMAN;tr|F5H0D0|F5H0D0_HUMAN",2457,"Q14232","EI2BA_HUMAN","Translation initiation factor eIF-2B subunit alpha",null,"EIF2B1"]
["24.0936","23.1688","23.6046","22.7113","22.2174","22.432",{"$nulls":3},"embryonic camera-type eye development;embryonic eye morphogenesis;face development;Harderian gland development;inner ear morphogenesis;locomotory behavior;neuromuscular process controlling balance;nucleus accumbens development;olfactory pit development;optic cup morphogenesis involved in camera-type eye development;positive regulation of apoptotic process;protein homotetramerization;retinal metabolic process;retinoic acid biosynthetic process;retinoic acid metabolic process;retinol metabolic process;righting reflex","aldehyde dehydrogenase (NAD) activity;aldehyde dehydrogenase [NAD(P)+] activity;NAD+ binding;protein homodimerization activity;retinal dehydrogenase activity;thyroid hormone binding","cytoplasm;cytosol;extracellular exosome;nucleus;plasma membrane","beta-Alanine metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Glycolysis / Gluconeogenesis;Histidine metabolism;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Phenylalanine metabolism;Tyrosine metabolism",null,null,27,27,23,"55.9","55.9","50.4","56.108",0,"210.1",2434700000,131,"1.74023",1,"1.16877","3.85741","sp|P47895|AL1A3_HUMAN;tr|H0Y2X5|H0Y2X5_HUMAN;tr|H0YKF9|H0YKF9_HUMAN;tr|H0YNQ3|H0YNQ3_HUMAN;tr|H0YLT1|H0YLT1_HUMAN","sp|P47895|AL1A3_HUMAN;tr|H0Y2X5|H0Y2X5_HUMAN",1614,"P47895","AL1A3_HUMAN","Aldehyde dehydrogenase family 1 member A3",null,"ALDH1A3"]
["20.5269","19.7996","19.8752","19.2267","18.6347","18.8708",{"$nulls":3},"bicellular tight junction assembly",null,"bicellular tight junction;integral component of membrane",{"$nulls":3},7,7,7,"18.6","18.6","18.6","59.129",0,"30.979",158700000,19,"1.79847",1,"1.15651","4.01694","tr|A0A0G2JMZ8|A0A0G2JMZ8_HUMAN;sp|Q16625|OCLN_HUMAN","tr|A0A0G2JMZ8|A0A0G2JMZ8_HUMAN;sp|Q16625|OCLN_HUMAN",2678,"A0A0G2JMZ8","A0A0G2JMZ8_HUMAN",null,null,"OCLN"]
["24.0678","23.8843","23.7043","22.8773","23.011","22.4582",{"$nulls":3},"negative regulation of cell proliferation","cadherin binding;RNA binding;zinc ion binding","cell junction;cytosol;focal adhesion;nucleus;plasma membrane;protein complex",{"$nulls":3},18,18,18,"54.2","54.2","54.2","47.996",0,"139.53",2793800000,76,"2.30322",1,"1.1033","5.60537","sp|Q9UGI8|TES_HUMAN;tr|F8W7T0|F8W7T0_HUMAN;tr|H7BYK1|H7BYK1_HUMAN;tr|F8WDI4|F8WDI4_HUMAN","sp|Q9UGI8|TES_HUMAN",5000,"Q9UGI8","TES_HUMAN","Testin",null,"TES"]
["23.2931","22.2694","22.1212","21.3842","21.2772","21.7147",{"$nulls":3},"bone morphogenesis;leukocyte migration;negative regulation of protein processing;negative regulation of transforming growth factor beta receptor signaling pathway;regulation of chondrocyte differentiation","fibroblast growth factor binding;receptor binding","extracellular exosome;Golgi apparatus;Golgi membrane;integral component of membrane;membrane;plasma membrane;proteinaceous extracellular matrix","Cell adhesion molecules (CAMs)",null,null,36,36,36,"39.1","39.1","39.1","134.55",0,"274.15",3895100000,221,"1.31941",1,"1.10249","2.81795","sp|Q92896|GSLG1_HUMAN;tr|H3BM42|H3BM42_HUMAN;tr|H3BQT1|H3BQT1_HUMAN;tr|H3BQU9|H3BQU9_HUMAN;tr|H3BRD8|H3BRD8_HUMAN","sp|Q92896|GSLG1_HUMAN;tr|H3BM42|H3BM42_HUMAN",3733,"Q92896","GSLG1_HUMAN","Golgi apparatus protein 1",null,"GLG1"]
["23.7638","23.309","22.9314","22.5432","21.6279","22.5332",{"$nulls":3},"cristae formation;inner mitochondrial membrane organization;mitochondrial fusion;negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","phosphatase binding;protein complex scaffold activity;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytoplasm;extracellular exosome;MICOS complex;mitochondrial inner membrane;mitochondrion;nucleus",{"$nulls":3},7,7,7,"28.2","28.2","28.2","26.152",0,"56.338",1042400000,41,"1.32922",1,"1.09993","2.8402","sp|Q9NX63|MIC19_HUMAN;tr|C9JRZ6|C9JRZ6_HUMAN;tr|F8WAR4|F8WAR4_HUMAN;tr|F8WD73|F8WD73_HUMAN","sp|Q9NX63|MIC19_HUMAN;tr|C9JRZ6|C9JRZ6_HUMAN;tr|F8WAR4|F8WAR4_HUMAN",4818,"Q9NX63","MIC19_HUMAN","MICOS complex subunit MIC19",null,"CHCHD3"]
["22.1449","21.2729","21.8835","20.7135","20.4733","20.8185",{"$nulls":3},"neutrophil degranulation;proteolysis","dipeptidyl-peptidase activity;serine-type peptidase activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region;Golgi apparatus;intracellular membrane-bounded organelle;vesicle",{"$nulls":3},14,14,14,"47.4","47.4","47.4","54.341",0,"129.27",523470000,37,"1.7759",1,"1.09873","3.9546","sp|Q9UHL4|DPP2_HUMAN;tr|R4GMR2|R4GMR2_HUMAN;tr|R4GNE8|R4GNE8_HUMAN;tr|R4GN05|R4GN05_HUMAN;tr|R4GMU5|R4GMU5_HUMAN;tr|R4GMV4|R4GMV4_HUMAN","sp|Q9UHL4|DPP2_HUMAN",5026,"Q9UHL4","DPP2_HUMAN","Dipeptidyl peptidase 2",null,"DPP7"]
["22.1456","21.1066","21.6016","20.7854","20.1003","20.7561",{"$nulls":9},12,12,12,"39.5","39.5","39.5","42.846",0,"117.93",547640000,47,"1.33836",1,"1.07066","2.86104","tr|A0A087WXI1|A0A087WXI1_HUMAN;sp|Q6NVY1|HIBCH_HUMAN;tr|B9A058|B9A058_HUMAN;tr|F8W8A6|F8W8A6_HUMAN;tr|H7C1A5|H7C1A5_HUMAN;tr|B8ZZZ0|B8ZZZ0_HUMAN;tr|H7C126|H7C126_HUMAN;tr|H7BYI7|H7BYI7_HUMAN;tr|H7C400|H7C400_HUMAN","tr|A0A087WXI1|A0A087WXI1_HUMAN;sp|Q6NVY1|HIBCH_HUMAN;tr|B9A058|B9A058_HUMAN",2982,"Q6NVY1",{"$nulls":3},"HIBCH"]
["27.0837","26.683","26.4111","25.8414","25.1168","26.0899",{"$nulls":3},"histone H3-K27 trimethylation;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;nucleosome assembly;nucleosome positioning","chromatin DNA binding;RNA binding","nuclear euchromatin;nucleosome;nucleus;transcriptionally active chromatin",{"$nulls":3},9,9,3,"33.3","33.3","13.6","21.364",0,"52.055",41162000000,306,"1.38574",1,"1.04318","2.97012","sp|P16403|H12_HUMAN","sp|P16403|H12_HUMAN",1135,"P16403","H12_HUMAN","Histone H1.2",null,"HIST1H1C"]
["19.851","20.3924","20.2918","19.2875","18.8664","19.2974",{"$nulls":3},"maturation of LSU-rRNA;positive regulation of cell proliferation;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;ribosomal large subunit assembly;rRNA base methylation","RNA binding;rRNA (cytosine-C5-)-methyltransferase activity","nucleolus;nucleoplasm",{"$nulls":3},14,14,14,"20.1","20.1","20.1","89.301",0,"57.276",490310000,56,"2.03147",1,"1.02798","4.70106","sp|P46087|NOP2_HUMAN;tr|A0A087WV73|A0A087WV73_HUMAN;tr|F5GWB7|F5GWB7_HUMAN;tr|F5H709|F5H709_HUMAN;tr|F5H5X6|F5H5X6_HUMAN;tr|F5H359|F5H359_HUMAN;tr|F5GYR3|F5GYR3_HUMAN;tr|F5H8G6|F5H8G6_HUMAN","sp|P46087|NOP2_HUMAN;tr|A0A087WV73|A0A087WV73_HUMAN",1586,"P46087","NOP2_HUMAN","Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase",null,"NOP2"]
["24.9992","24.0315","24.198","23.4837","23.3037","23.3855",{"$nulls":3},"autophagic cell death;establishment of protein localization to organelle;Golgi to lysosome transport;granzyme-mediated apoptotic signaling pathway;neutrophil degranulation;positive regulation of natural killer cell degranulation;positive regulation of natural killer cell mediated cytotoxicity;protein stabilization;regulation of organelle transport along microtubule","enzyme binding;protein domain specific binding;virus receptor activity","alveolar lamellar body;autolysosome;azurophil granule membrane;cytolytic granule;cytoplasm;cytosol;dendrite;endosome membrane;external side of plasma membrane;extracellular exosome;ficolin-1-rich granule membrane;integral component of plasma membrane;late endosome;lysosomal membrane;lysosome;melanosome;membrane;multivesicular body;neuronal cell body;perinuclear region of cytoplasm;phagolysosome membrane;plasma membrane;sarcolemma;synaptic vesicle","Autophagy - animal;Lysosome;Phagosome;Tuberculosis",null,null,8,8,8,"16.5","16.5","16.5","44.882",0,"159.99",3027000000,39,"1.54794",1,"1.01862","3.35951","sp|P11279|LAMP1_HUMAN","sp|P11279|LAMP1_HUMAN",1044,"P11279","LAMP1_HUMAN","Lysosome-associated membrane glycoprotein 1","AMP-1;ysosome-associated membrane protein 1","LAMP1"]
[]
["15.6258","15.0404","15.9141","17.0468","16.3417","16.5003",{"$nulls":3},"neuron projection development",null,"growth cone;plasma membrane",{"$nulls":3},4,4,4,"5.5","5.5","5.5","102.4",0,"6.6968",65566000,6,"1.52391",1,"-1.10281","-3.30016","sp|Q7Z2K8|GRIN1_HUMAN","sp|Q7Z2K8|GRIN1_HUMAN",3144,"Q7Z2K8","GRIN1_HUMAN","G protein-regulated inducer of neurite outgrowth 1","RIN1","GPRIN1"]
["20.0182","19.1007","19.6853","21.3977","20.9595","21.1007",{"$nulls":3},"brain development;cellular response to cholesterol;cellular response to follicle-stimulating hormone stimulus;cholesterol biosynthetic process;isoprenoid biosynthetic process;lipid metabolic process;liver development;male gonad development;regulation of cholesterol biosynthetic process;regulation of lipid metabolic process;response to drug;response to low light intensity stimulus;response to low-density lipoprotein particle stimulus;response to purine-containing compound;response to tellurium ion;response to vitamin E","drug binding;hydroxymethylglutaryl-CoA synthase activity;isomerase activity;organic acid binding;protein homodimerization activity","cytoplasm;cytosol","Butanoate metabolism;Metabolic pathways;PPAR signaling pathway;Synthesis and degradation of ketone bodies;Terpenoid backbone biosynthesis;Valine, leucine and isoleucine degradation",null,null,10,10,10,"25.8","25.8","25.8","57.293",0,"36.864",392180000,22,"2.18953",1,"-1.55118","-5.21183","sp|Q01581|HMCS1_HUMAN;tr|D6RIW1|D6RIW1_HUMAN;sp|P54868|HMCS2_HUMAN","sp|Q01581|HMCS1_HUMAN",2140,"Q01581","HMCS1_HUMAN","Hydroxymethylglutaryl-CoA synthase, cytoplasmic","MG-CoA synthase","HMGCS1"]
["20.9229","19.593","20.2782","22.7148","21.1808","22.1264",{"$nulls":3},"amelogenesis;autophagy;cell adhesion;cell motility;cell-matrix adhesion;digestive tract development;extracellular matrix organization;hemidesmosome assembly;integrin-mediated signaling pathway;mesodermal cell differentiation;nail development;renal system development;response to wounding;skin development","G-protein coupled receptor binding;receptor activity","cell junction;cell leading edge;cell surface;extracellular exosome;hemidesmosome;integrin complex;nucleus;plasma membrane;receptor complex","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);PI3K-Akt signaling pathway;Regulation of actin cytoskeleton",null,null,44,44,35,"32.5","32.5","25.9","202.16",0,"323.31",2667400000,187,"1.3805",1,"-1.74261","-2.95795","sp|P16144|ITB4_HUMAN;tr|J3QQL2|J3QQL2_HUMAN;tr|J3QRK0|J3QRK0_HUMAN;tr|J3KSH9|J3KSH9_HUMAN","sp|P16144|ITB4_HUMAN",1130,"P16144","ITB4_HUMAN","Integrin beta-4",null,"ITGB4"]
["14.9787","13.8075","16.1981","17.2966","16.8086","17.2",{"$nulls":3},"endocytosis;protein transport",null,"cytosol;endosome;plasma membrane",{"$nulls":3},16,14,14,21,"19.7","19.7","140.02",0,"63.992",276070000,43,"1.39169",1,"-2.10699","-2.98396","sp|Q8NDI1|EHBP1_HUMAN;tr|B5MC86|B5MC86_HUMAN;tr|C9IYU2|C9IYU2_HUMAN;tr|C9K0H9|C9K0H9_HUMAN;tr|C9J268|C9J268_HUMAN;tr|H7C0Q4|H7C0Q4_HUMAN;tr|H7BZ98|H7BZ98_HUMAN","sp|Q8NDI1|EHBP1_HUMAN",3483,"Q8NDI1","EHBP1_HUMAN","EH domain-binding protein 1",null,"EHBP1"]
["20.782","24.2772","22.673","25.1547","26.7897","25.8482",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"10.2","10.2","10.2","13.328","0.0026728","2.9346",4815100000,13,"1.401",1,"-3.35345","-3.00568","tr|X6RI56|X6RI56_HUMAN;sp|O94886|CSCL1_HUMAN","tr|X6RI56|X6RI56_HUMAN;sp|O94886|CSCL1_HUMAN",685,"X6RI56","X6RI56_HUMAN",null,null,"TMEM63A"]
[1,1,1,"15.9575","13.7739","15.249",{"$nulls":3},"cellular response to leukemia inhibitory factor;energy reserve metabolic process;fructose 6-phosphate metabolic process;glutamine metabolic process;protein N-linked glycosylation;UDP-N-acetylglucosamine biosynthetic process;UDP-N-acetylglucosamine metabolic process","carbohydrate derivative binding;glutamine-fructose-6-phosphate transaminase (isomerizing) activity","cytosol","Alanine, aspartate and glutamate metabolism;Amino sugar and nucleotide sugar metabolism;Insulin resistance;Metabolic pathways",null,null,9,4,4,"18.9","8.2","8.2","76.93",0,"7.8547",24555000,5,"4.57831",1,"-13.9935","-21.7566","sp|O94808|GFPT2_HUMAN;tr|E5RJP4|E5RJP4_HUMAN","sp|O94808|GFPT2_HUMAN;tr|E5RJP4|E5RJP4_HUMAN",677,"O94808","GFPT2_HUMAN","Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2",null,"GFPT2"]
[1,1,1,"18.0835","14.0201","17.8433",{"$nulls":3},"cell proliferation;glucose metabolic process;hypoxia-inducible factor-1alpha signaling pathway;intrinsic apoptotic signaling pathway in response to oxidative stress;regulation of acetyl-CoA biosynthetic process from pyruvate;regulation of glucose metabolic process","ATP binding;protein kinase activity;pyruvate dehydrogenase (acetyl-transferring) kinase activity","mitochondrial matrix;mitochondrial pyruvate dehydrogenase complex;mitochondrion;nucleolus;nucleus","Axon guidance;Central carbon metabolism in cancer;HIF-1 signaling pathway",null,null,3,3,3,8,8,8,"49.244","0.00041271","4.1433",21375000,1,"3.54263",1,"-15.649","-11.8889","sp|Q15118|PDK1_HUMAN;tr|F8WC75|F8WC75_HUMAN;tr|C9JKT3|C9JKT3_HUMAN;tr|F8WEJ6|F8WEJ6_HUMAN;tr|C9IYB4|C9IYB4_HUMAN","sp|Q15118|PDK1_HUMAN",2560,"Q15118","PDK1_HUMAN","[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial",null,"PDK1"]
[1,1,1,"18.0257","17.0138","16.3836",{"$nulls":4},"transferase activity, transferring hexosyl groups",{"$nulls":4},3,3,1,21,21,"4.3","17.801","0.0043023","2.6015",36477000,3,"5.3374",1,"-16.141","-33.7485","tr|A0A096LP10|A0A096LP10_HUMAN;tr|A0A087WT15|A0A087WT15_HUMAN","tr|A0A096LP10|A0A096LP10_HUMAN",5443,"A0A096LP10","A0A096LP10_HUMAN",null,null,"ALG13"]
[1,1,1,"19.2526","17.1755","18.1341",{"$nulls":9},2,2,2,"14.9","14.9","14.9","21.529",0,"6.02",23433000,1,"5.05307",1,"-17.1874","-28.6369","tr|D6RJ90|D6RJ90_HUMAN;sp|Q9Y6G5|COMDA_HUMAN;tr|H0Y9N4|H0Y9N4_HUMAN;tr|D6RC04|D6RC04_HUMAN","tr|D6RJ90|D6RJ90_HUMAN;sp|Q9Y6G5|COMDA_HUMAN;tr|H0Y9N4|H0Y9N4_HUMAN;tr|D6RC04|D6RC04_HUMAN",5407,"Q9Y6G5","D6RJ90_HUMAN",null,null,"COMMD10"]
[1,1,1,"19.6257","17.0328","19.436",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,17,17,17,"10.809","0.0035687","2.6738",16635000,1,"4.53431",1,"-17.6982","-21.2087","tr|A0A096LPB2|A0A096LPB2_HUMAN;tr|A0A096LP01|A0A096LP01_HUMAN","tr|A0A096LPB2|A0A096LPB2_HUMAN;tr|A0A096LP01|A0A096LP01_HUMAN",5442,"A0A096LPB2","A0A096LPB2_HUMAN",null,null,"SMIM26"]
[1,1,1,"19.8363","18.4446","19.4707",{"$nulls":3},"cytoplasmic microtubule organization;microtubule depolymerization;negative regulation of Rac protein signal transduction;nervous system development;neuron projection development;regulation of cytoskeleton organization;regulation of GTPase activity;regulation of microtubule polymerization or depolymerization","protein domain specific binding;tubulin binding","axon;cytoplasm;Golgi apparatus;growth cone;neuron projection",{"$nulls":3},2,2,2,10,10,10,"21.017","0.002842","2.7833",25226000,3,"5.78967",1,"-18.2505","-43.8106","sp|Q9NZ72|STMN3_HUMAN;tr|A0A0J9YW36|A0A0J9YW36_HUMAN","sp|Q9NZ72|STMN3_HUMAN;tr|A0A0J9YW36|A0A0J9YW36_HUMAN",4870,"Q9NZ72","STMN3_HUMAN","Stathmin-3",null,"STMN3"]

{"sheet":"SW480_Allproteins_3DsiKvssiC","index":2,"n_rows":2947,"n_cols":36,"rows_kept":2947}
["3D siKRAS 1 ","3D siKRAS 2","3D NT 1 ","3D NT 2 ","C: Only identified by site","C: Reverse","C: Potential contaminant","C: GOBP name","C: GOMF name","C: GOCC name","C: KEGG pathway name","C: Student's T-test Significant 3D siKRAS_3D NT","C: Student's T-test significant","N: Peptides","N: Razor + unique peptides","N: Unique peptides","N: Sequence coverage [%]","N: Unique + razor sequence coverage [%]","N: Unique sequence coverage [%]","N: Mol. weight [kDa]","N: Q-value","N: Score","N: Intensity","N: MS/MS Count","N: -Log Student's T-test p-value 3D siKRAS_3D NT","N: Student's T-test q-value 3D siKRAS_3D NT","N: Student's T-test Difference 3D siKRAS_3D NT","N: Student's T-test Test statistic 3D siKRAS_3D NT","T: Protein IDs","T: Majority protein IDs","T: id","T: Uniprot IDs","T: Uniprot name","T: Uniprot full protein name","T: Uniprot short protein name","T: Gene name"]
["22.0783","21.8296",1,1,{"$nulls":4},"transcription coactivator activity","nucleus",{"$nulls":3},1,1,1,30,30,30,"6.8585","0.00039494","3.2904",25687000,2,"4.45327","0.393333","20.954","168.509","tr|J3KTD8|J3KTD8_HUMAN","tr|J3KTD8|J3KTD8_HUMAN",3110,"J3KTD8","J3KTD8_HUMAN",null,null,"CBFB"]
["19.3371","19.7789",1,1,{"$nulls":9},1,1,1,"16.9","16.9","16.9","9.7027","0.0063249","1.8465",16566000,1,"3.8489","0.406095","18.558","84.0245","tr|F8WF15|F8WF15_HUMAN;tr|F8W8F0|F8W8F0_HUMAN;tr|C9J180|C9J180_HUMAN;sp|Q96LR5|UB2E2_HUMAN","tr|F8WF15|F8WF15_HUMAN;tr|F8W8F0|F8W8F0_HUMAN;tr|C9J180|C9J180_HUMAN;sp|Q96LR5|UB2E2_HUMAN",2326,"F8WF15","F8WF15_HUMAN",null,null,"UBE2E2"]
["19.6104","19.4939",1,1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"21.7","21.7","21.7","8.8131",0,"39.841",41441000,8,"5.00668","0.272","18.5521","318.667","tr|C9JAW5|C9JAW5_HUMAN;sp|Q9Y241|HIG1A_HUMAN;tr|C9JNU6|C9JNU6_HUMAN","tr|C9JAW5|C9JAW5_HUMAN;sp|Q9Y241|HIG1A_HUMAN;tr|C9JNU6|C9JNU6_HUMAN",2938,"C9JAW5","C9JAW5_HUMAN"]
["18.213","18.2832",1,1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,3,3,3,"38.309","0.0010784","2.4289",18691000,4,"5.38349","0.544","17.2481","491.747","tr|A0A0A0MT98|A0A0A0MT98_HUMAN;tr|A0A0G2JKZ1|A0A0G2JKZ1_HUMAN;sp|O15533|TPSN_HUMAN;tr|A2AB90|A2AB90_HUMAN;tr|A0A0G2JH37|A0A0G2JH37_HUMAN;tr|A0A0A0MSV9|A0A0A0MSV9_HUMAN","tr|A0A0A0MT98|A0A0A0MT98_HUMAN;tr|A0A0G2JKZ1|A0A0G2JKZ1_HUMAN;sp|O15533|TPSN_HUMAN;tr|A2AB90|A2AB90_HUMAN;tr|A0A0G2JH37|A0A0G2JH37_HUMAN;tr|A0A0A0MSV9|A0A0A0MSV9_HUMAN",226,"A0A0A0MT98","A0A0A0MT98_HUMAN",null,null,"TAPBP"]
["18.0497","17.7147",1,1,{"$nulls":9},1,1,1,"8.4","8.4","8.4","37.353",0,"3.5654",30041000,1,"4.00683","0.334316","16.8822","100.782","tr|F5GZY1|F5GZY1_HUMAN;sp|Q9H993|ARMT1_HUMAN","tr|F5GZY1|F5GZY1_HUMAN;sp|Q9H993|ARMT1_HUMAN",2619,"F5GZY1","F5GZY1_HUMAN",null,null,"ARMT1"]
["17.6584","18.0331",1,1,{"$nulls":5},"nucleolus",{"$nulls":3},1,1,1,3,3,3,"48.208",0,"3.7326",10452000,2,"3.90793","0.3448","16.8457","89.9341","tr|J3QSV6|J3QSV6_HUMAN;sp|O76021|RL1D1_HUMAN","tr|J3QSV6|J3QSV6_HUMAN;sp|O76021|RL1D1_HUMAN",384,"J3QSV6","J3QSV6_HUMAN",null,null,"RSL1D1"]
["17.924","17.5144",1,1,{"$nulls":9},1,1,1,24,24,24,"5.4142","0.0063207","1.8408",10260000,1,"3.82372","0.370783","16.7192","81.6225","tr|D6R907|D6R907_HUMAN;tr|D6RBI9|D6RBI9_HUMAN;tr|D6RBR6|D6RBR6_HUMAN;tr|D6RFG3|D6RFG3_HUMAN;tr|D6REL6|D6REL6_HUMAN;tr|I6L9I8|I6L9I8_HUMAN;sp|Q9Y6I3|EPN1_HUMAN;sp|Q9H201|EPN3_HUMAN","tr|D6R907|D6R907_HUMAN;tr|D6RBI9|D6RBI9_HUMAN;tr|D6RBR6|D6RBR6_HUMAN;tr|D6RFG3|D6RFG3_HUMAN;tr|D6REL6|D6REL6_HUMAN;tr|I6L9I8|I6L9I8_HUMAN;sp|Q9Y6I3|EPN1_HUMAN;sp|Q9H201|EPN3_HUMAN",2571,"D6R907","D6R907_HUMAN",null,null,"EPN3"]
["17.4439","16.8852",1,1,{"$nulls":3},"actin cytoskeleton organization;endocytosis",null,"intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},2,2,2,"7.8","7.8","7.8","49.712","0.0047749","2.0326",12021000,2,"3.52515","0.41125","16.1646","57.8729","tr|M0R0F9|M0R0F9_HUMAN;tr|W4VSQ9|W4VSQ9_HUMAN;sp|Q15642|CIP4_HUMAN;tr|M0R070|M0R070_HUMAN;tr|M0R2H7|M0R2H7_HUMAN","tr|M0R0F9|M0R0F9_HUMAN;tr|W4VSQ9|W4VSQ9_HUMAN;sp|Q15642|CIP4_HUMAN;tr|M0R070|M0R070_HUMAN;tr|M0R2H7|M0R2H7_HUMAN",1711,"M0R0F9","M0R0F9_HUMAN",null,null,"TRIP10"]
["17.113","16.9009",1,1,{"$nulls":3},"androgen receptor signaling pathway;circadian rhythm;intracellular steroid hormone receptor signaling pathway;mRNA processing;mRNA stabilization;nuclear-transcribed mRNA catabolic process;positive regulation of circadian rhythm;positive regulation of mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of alternative mRNA splicing, via spliceosome;RNA splicing;transcription initiation from RNA polymerase II promoter","ATP binding;core promoter sequence-specific DNA binding;ligand-dependent nuclear receptor transcription coactivator activity;phosphoprotein binding;receptor activity;RNA binding;RNA polymerase II transcription cofactor activity;thyroid hormone receptor binding;transcription coactivator activity;transcription cofactor activity;vitamin D receptor binding","extracellular exosome;mediator complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"4.3","4.3","4.3","108.66","0.0044384","2.0412",11093000,2,"4.35763","0.295","16.0069","150.938","sp|Q9Y2W1|TR150_HUMAN","sp|Q9Y2W1|TR150_HUMAN",2960,"Q9Y2W1","TR150_HUMAN","Thyroid hormone receptor-associated protein 3",null,"THRAP3"]
["16.7172","16.9115",1,1,{"$nulls":5},"cytosol;Golgi apparatus;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"2.8","2.8","2.8","60.741",0,"8.6202",10786000,3,"4.42338","0.337143","15.8143","162.808","sp|Q8IWE2|NXP20_HUMAN","sp|Q8IWE2|NXP20_HUMAN",2013,"Q8IWE2","NXP20_HUMAN","Protein NOXP20",null,"FAM114A1"]
["18.6178","14.7599",1,1,{"$nulls":3},"tRNA modification;wybutosine biosynthetic process","iron ion binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;protein homodimerization activity;tRNA binding;tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity","cytoplasm",{"$nulls":3},1,1,1,"2.5","2.5","2.5","36.547","0.0075758","1.7615",59591000,2,"1.83026","0.392292","15.6889","8.13345","sp|A2RUC4|TYW5_HUMAN","sp|A2RUC4|TYW5_HUMAN",98,"A2RUC4","TYW5_HUMAN","tRNA wybutosine-synthesizing protein 5","TYW5","TYW5"]
["16.7224","16.529",1,1,{"$nulls":3},"cell recognition;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;homophilic cell adhesion via plasma membrane adhesion molecules","cell adhesion molecule binding;protein homodimerization activity;receptor activity;receptor binding","cell-cell adherens junction;extracellular exosome;integral component of plasma membrane",{"$nulls":3},1,1,1,"4.6","4.6","4.6","42.785","0.0031013","2.1168",18897000,1,"4.41677","0.314667","15.6257","161.574","sp|Q8NFZ8|CADM4_HUMAN","sp|Q8NFZ8|CADM4_HUMAN",2100,"Q8NFZ8","CADM4_HUMAN","Cell adhesion molecule 4",null,"CADM4"]
["16.2521","16.3353",1,1,{"$nulls":3},"carbohydrate metabolic process;glucosamine catabolic process;N-acetylglucosamine metabolic process","glucosamine-6-phosphate deaminase activity","cytosol;nucleus","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,2,1,1,17,"10.9","10.9","31.084","0.004749","1.99",7979400,1,"5.13185","0.3264","15.2937","368.065","sp|Q8TDQ7|GNPI2_HUMAN","sp|Q8TDQ7|GNPI2_HUMAN",2121,"Q8TDQ7","GNPI2_HUMAN","Glucosamine-6-phosphate isomerase 2",null,"GNPDA2"]
["16.0467","16.2306",1,1,{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},1,1,1,2,2,2,"102.13","0.00039432","3.2748",11418000,1,"4.43308","0.363077","15.1387","164.638","tr|A0A087WWP4|A0A087WWP4_HUMAN;sp|Q96T37|RBM15_HUMAN","tr|A0A087WWP4|A0A087WWP4_HUMAN;sp|Q96T37|RBM15_HUMAN",2360,"A0A087WWP4","A0A087WWP4_HUMAN",null,null,"RBM15"]
["16.1281","15.976",1,1,{"$nulls":4},"methyltransferase activity","nucleolus",{"$nulls":3},1,1,1,"4.2","4.2","4.2","34.2","0.002772","2.1738",2449400,1,"4.59331","0.429091","15.0521","197.992","tr|E9PPY3|E9PPY3_HUMAN;sp|O43159|RRP8_HUMAN","tr|E9PPY3|E9PPY3_HUMAN;sp|O43159|RRP8_HUMAN",231,"E9PPY3","E9PPY3_HUMAN",null,null,"RRP8"]
["15.1243","15.6315",1,1,{"$nulls":9},1,1,1,"3.2","3.2","3.2","79.972",0,"4.1769",10687000,3,"3.50735","0.387059","14.3779","56.6989","tr|H0YAJ5|H0YAJ5_HUMAN;tr|G5E9Y1|G5E9Y1_HUMAN;sp|Q92870|APBB2_HUMAN","tr|H0YAJ5|H0YAJ5_HUMAN;tr|G5E9Y1|G5E9Y1_HUMAN;sp|Q92870|APBB2_HUMAN",2197,"H0YAJ5","H0YAJ5_HUMAN",null,null,"APBB2"]
["15.2169","14.7315",1,1,{"$nulls":9},1,1,1,"1.4","1.4","1.4","88.181","0.003096","2.0916",17737000,1,"3.52077","0.398788","13.9742","57.5822","tr|C9J8U1|C9J8U1_HUMAN;tr|F8WAN1|F8WAN1_HUMAN;sp|Q69YQ0|CYTSA_HUMAN","tr|C9J8U1|C9J8U1_HUMAN;tr|F8WAN1|F8WAN1_HUMAN;sp|Q69YQ0|CYTSA_HUMAN",1861,"C9J8U1","C9J8U1_HUMAN",null,null,"SPECC1L"]
["14.1172","14.4393",1,1,{"$nulls":3},"axon development;microtubule cytoskeleton organization;regulation of dendrite development;regulation of Golgi organization;regulation of microtubule polymerization;regulation of organelle organization","calmodulin binding;microtubule minus-end binding;spectrin binding","cytosol;Golgi apparatus;microtubule end",{"$nulls":3},1,1,1,"0.9","0.9","0.9","168.09",0,"28.136",3422800,9,"3.83253","0.387636","13.2783","82.4548","sp|Q08AD1|CAMP2_HUMAN","sp|Q08AD1|CAMP2_HUMAN",1478,"Q08AD1","CAMP2_HUMAN","Calmodulin-regulated spectrin-associated protein 2 {ECO:0000305}",null,"CAMSAP2"]
["27.051","26.9333",1,"26.6088",{"$nulls":9},1,1,1,"28.9","28.9","28.9","5.1488","0.00076953","3.0139",1434400000,5,"0.38584","0.632651","13.1877","1.02993","tr|E9PPX6|E9PPX6_HUMAN","tr|E9PPX6|E9PPX6_HUMAN",3093,"E9PPX6","E9PPX6_HUMAN",null,null,"ATPAF1"]
["13.7623","13.8873",1,1,{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell cycle;cell division;mitotic sister chromatid cohesion;mitotic spindle assembly;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of cell proliferation;positive regulation of synapse maturation;positive regulation of synaptic plasticity;positive regulation of ubiquitin protein ligase activity;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of dendrite development;regulation of meiotic nuclear division;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;sister chromatid cohesion","anaphase-promoting complex binding;enzyme binding;histone deacetylase binding;protein C-terminus binding;ubiquitin-protein transferase activator activity","centrosome;cytosol;nucleoplasm;perinuclear region of cytoplasm;protein complex;spindle;spindle pole","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Ubiquitin mediated proteolysis;Viral carcinogenesis",null,null,1,1,1,"2.2","2.2","2.2","54.722","0.0010646","2.3595",6752100,2,"4.6241","0.472","12.8248","205.136","sp|Q12834|CDC20_HUMAN","sp|Q12834|CDC20_HUMAN",1498,"Q12834","CDC20_HUMAN","Cell division cycle protein 20 homolog",null,"CDC20"]
["12.5208","13.0494",1,1,{"$nulls":5},"cytoplasm;microtubule",{"$nulls":3},2,2,2,"1.9","1.9","1.9","171.69",0,"6.3509",17586000,2,"3.29877","0.436098","11.7851","44.5886","sp|Q9Y4F5|C170B_HUMAN;tr|J3KQR7|J3KQR7_HUMAN","sp|Q9Y4F5|C170B_HUMAN;tr|J3KQR7|J3KQR7_HUMAN",2999,"Q9Y4F5","C170B_HUMAN","Centrosomal protein of 170 kDa protein B",null,"CEP170B"]
["21.424","21.6134","20.3394",1,{"$nulls":9},2,2,2,"30.9","30.9","30.9","9.4367",0,"5.8979",146930000,5,"0.421926","0.592848","10.849","1.12191","tr|A0A087WWJ2|A0A087WWJ2_HUMAN;tr|C9J5D1|C9J5D1_HUMAN;tr|E7EQ69|E7EQ69_HUMAN;sp|Q9GZZ1|NAA50_HUMAN;tr|F8WCK0|F8WCK0_HUMAN;tr|C9JZU6|C9JZU6_HUMAN;tr|C9J5J3|C9J5J3_HUMAN;tr|A0A0D9SF32|A0A0D9SF32_HUMAN;tr|B0AZT5|B0AZT5_HUMAN","tr|A0A087WWJ2|A0A087WWJ2_HUMAN;tr|C9J5D1|C9J5D1_HUMAN;tr|E7EQ69|E7EQ69_HUMAN;sp|Q9GZZ1|NAA50_HUMAN;tr|F8WCK0|F8WCK0_HUMAN;tr|C9JZU6|C9JZU6_HUMAN;tr|C9J5J3|C9J5J3_HUMAN;tr|A0A0D9SF32|A0A0D9SF32_HUMAN;tr|B0AZT5|B0AZT5_HUMAN",2547,"A0A087WWJ2","A0A087WWJ2_HUMAN",null,null,"NAA50"]
["20.7499","20.4796",1,"19.7938",{"$nulls":3},"tricarboxylic acid cycle","cofactor binding;nucleotide binding;RNA binding;succinate-CoA ligase (ADP-forming) activity;succinate-CoA ligase (GDP-forming) activity","cytosol;extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;plasma membrane","Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways;Propanoate metabolism",null,null,2,2,2,"8.7","8.7","8.7","36.249",0,"3.5775",158510000,10,"0.408377","0.609757","10.2179","1.08725","sp|P53597|SUCA_HUMAN","sp|P53597|SUCA_HUMAN",1180,"P53597","SUCA_HUMAN","Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03222}",null,"SUCLG1"]
["21.208","20.5844",1,"20.3814",{"$nulls":9},1,1,1,"68.3","68.3","68.3","3.9694","0.0010601","2.3317",42481000,4,"0.394762","0.624158","10.2055","1.05258","tr|K7ENI6|K7ENI6_HUMAN;tr|K7ERE1|K7ERE1_HUMAN;sp|Q8N2U0|TM256_HUMAN","tr|K7ENI6|K7ENI6_HUMAN;tr|K7ERE1|K7ERE1_HUMAN;sp|Q8N2U0|TM256_HUMAN",2042,"K7ENI6","K7ENI6_HUMAN",null,null,"TMEM256-PLSCR3"]
["19.5449","19.4448",1,"17.6251",{"$nulls":9},1,1,1,"18.7","18.7","18.7","8.2506",0,"22.69",17093000,6,"0.461804","0.541144","10.1822","1.2249","tr|J3QKQ1|J3QKQ1_HUMAN;tr|J3KRR1|J3KRR1_HUMAN;tr|J9JIC5|J9JIC5_HUMAN;sp|Q9HAS0|NJMU_HUMAN","tr|J3QKQ1|J3QKQ1_HUMAN;tr|J3KRR1|J3KRR1_HUMAN;tr|J9JIC5|J9JIC5_HUMAN;sp|Q9HAS0|NJMU_HUMAN",2629,"J3QKQ1","J3QKQ1_HUMAN",null,null,"C17orf75"]
["19.0534","19.4308","17.2086",1,{"$nulls":3},"cell cycle arrest;regulation of cell proliferation","cyclin-dependent protein serine/threonine kinase inhibitor activity","cytoplasm;nucleus",{"$nulls":3},2,2,2,"22.1","22.1","22.1","11.94",0,"5.5083",10719000,3,"0.471646","0.532481","10.1378","1.25058","tr|H7C2T1|H7C2T1_HUMAN;sp|P46527|CDN1B_HUMAN","tr|H7C2T1|H7C2T1_HUMAN;sp|P46527|CDN1B_HUMAN",1029,"H7C2T1","H7C2T1_HUMAN",null,null,"CDKN1B"]
["20.8737","22.0967",1,"22.0065",{"$nulls":3},"BMP signaling pathway;female gonad development;male gonad development;Mullerian duct regression;negative regulation of anti-Mullerian hormone signaling pathway;sex differentiation;signal transduction;transforming growth factor beta receptor signaling pathway","anti-Mullerian hormone receptor activity;ATP binding;hormone binding;metal ion binding;receptor activity;signal transducer, downstream of receptor, with serine/threonine kinase activity;transforming growth factor beta receptor activity, type II","integral component of plasma membrane;plasma membrane","Cytokine-cytokine receptor interaction;TGF-beta signaling pathway",null,null,1,1,1,"1.6","1.6","1.6","62.749","0.0027807","2.1983",723770000,5,"0.353713","0.682642","9.98198","0.948766","sp|Q16671|AMHR2_HUMAN","sp|Q16671|AMHR2_HUMAN",1750,"Q16671","AMHR2_HUMAN","Anti-Muellerian hormone type-2 receptor",null,"AMHR2"]
["20.8849","21.1224",1,"21.1215",{"$nulls":9},3,3,3,"26.1","26.1","26.1","17.385",0,"17.763",160520000,9,"0.369358","0.65942","9.94291","0.988219","tr|H3BV16|H3BV16_HUMAN;tr|H3BPJ9|H3BPJ9_HUMAN;sp|O96000|NDUBA_HUMAN","tr|H3BV16|H3BV16_HUMAN;tr|H3BPJ9|H3BPJ9_HUMAN;sp|O96000|NDUBA_HUMAN",458,"H3BV16","H3BV16_HUMAN",null,null,"NDUFB10"]
["20.065","19.9515",1,"19.1539",{"$nulls":5},"endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},1,1,1,19,19,19,"18.038",0,"3.706",47958000,8,"0.411061","0.606554","9.93132","1.09411","tr|I3L1T3|I3L1T3_HUMAN;sp|Q9GZP9|DERL2_HUMAN","tr|I3L1T3|I3L1T3_HUMAN;sp|Q9GZP9|DERL2_HUMAN",2538,"I3L1T3","I3L1T3_HUMAN","Derlin {ECO:0000256|RuleBase:RU363059}",null,"DERL2"]
["19.4823","18.7825",1,"17.8808",{"$nulls":3},"detection of chemical stimulus involved in sensory perception of bitter taste;negative regulation of cysteine-type endopeptidase activity","cysteine-type endopeptidase inhibitor activity;protease binding","extracellular space","Salivary secretion",null,null,1,1,1,"15.6","15.6","15.6","16.387","0.00040145","3.3992",17906000,2,"0.431814","0.57872","9.69199","1.1473","sp|P01037|CYTN_HUMAN","sp|P01037|CYTN_HUMAN",478,"P01037","CYTN_HUMAN","Cystatin-SN",null,"CST1"]
["20.0033","18.8566",1,"18.7553",{"$nulls":9},1,1,1,"24.6","24.6","24.6","14.853",0,"23.158",17866000,4,"0.403084","0.618336","9.55231","1.07376","tr|Q5T1J1|Q5T1J1_HUMAN;sp|Q99720|SGMR1_HUMAN","tr|Q5T1J1|Q5T1J1_HUMAN;sp|Q99720|SGMR1_HUMAN",2393,"Q5T1J1","Q5T1J1_HUMAN",null,null,"SIGMAR1"]
["19.5763","19.4217",1,"19.1939",{"$nulls":3},"defense response to virus;DNA deamination;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;histone mRNA catabolic process;maturation of 5.8S rRNA;nuclear mRNA surveillance;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';polyadenylation-dependent snoRNA 3'-end processing;positive regulation of cell growth;regulation of mRNA stability;rRNA 3'-end processing;rRNA catabolic process;rRNA processing;U4 snRNA 3'-end processing","3'-5'-exoribonuclease activity;AU-rich element binding","cytoplasm;cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);intermediate filament cytoskeleton;nuclear exosome (RNase complex);nucleolus;nucleoplasm;nucleus;transcriptionally active chromatin","RNA degradation",null,null,1,1,1,"4.1","4.1","4.1","26.383",0,"4.1763",53902000,6,"0.387251","0.632579","9.40208","1.03351","sp|Q9NPD3|EXOS4_HUMAN;tr|E9PI41|E9PI41_HUMAN","sp|Q9NPD3|EXOS4_HUMAN;tr|E9PI41|E9PI41_HUMAN",2659,"Q9NPD3","EXOS4_HUMAN","Exosome complex component RRP41",null,"EXOSC4"]
["20.7255","20.2672","21.2327",1,{"$nulls":3},"cellular response to gamma radiation;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;negative regulation of cell death;regulation of ion transmembrane transport","voltage-gated ion channel activity","extracellular exosome;integral component of membrane;nuclear outer membrane;sarcoplasmic reticulum membrane",{"$nulls":3},2,2,2,"8.6","8.6","8.6","26.21","0.0047651","2.0084",156910000,2,"0.345054","0.689389","9.37999","0.926974","sp|Q9BVC6|TM109_HUMAN","sp|Q9BVC6|TM109_HUMAN",2471,"Q9BVC6","TM109_HUMAN","Transmembrane protein 109",null,"TMEM109"]
["20.3838","19.8701",1,"20.7893",{"$nulls":3},"activation of GTPase activity;negative regulation of cell proliferation;negative regulation of protein localization to cell surface;negative regulation of Wnt signaling pathway;Rho protein signal transduction;Wnt signaling pathway","beta-catenin binding;protein C-terminus binding","actin cytoskeleton;cytoplasm;cytosol;extracellular exosome;fibrillar center;intracellular membrane-bounded organelle;plasma membrane",{"$nulls":3},1,1,1,"13.7","13.7","13.7","13.735",0,"13.978",87874000,7,"0.34735","0.68752","9.23234","0.932749","sp|O14907|TX1B3_HUMAN","sp|O14907|TX1B3_HUMAN",178,"O14907","TX1B3_HUMAN","Tax1-binding protein 3",null,"TAX1BP3"]
["19.2502","19.3286",1,"19.1848",{"$nulls":9},1,1,1,"41.5","41.5","41.5","7.2592","0.0027739","2.1759",19187000,7,"0.378564","0.644326","9.19701","1.0115","tr|F2Z3H2|F2Z3H2_HUMAN;sp|O95870|ABHGA_HUMAN;tr|A0A0G2JJD3|A0A0G2JJD3_HUMAN","tr|F2Z3H2|F2Z3H2_HUMAN;sp|O95870|ABHGA_HUMAN;tr|A0A0G2JJD3|A0A0G2JJD3_HUMAN",457,"F2Z3H2","F2Z3H2_HUMAN",null,null,"ABHD16A"]
["19.8254","19.4759","19.9142",1,{"$nulls":9},1,1,1,"9.9","9.9","9.9","16.997","0.0010858","2.5054",58678000,1,"0.362919","0.666897","9.19355","0.971966","sp|Q7Z422|SZRD1_HUMAN","sp|Q7Z422|SZRD1_HUMAN",1952,"Q7Z422","SZRD1_HUMAN","SUZ domain-containing protein 1",null,"SZRD1"]
["19.8779","19.463","19.9594",1,{"$nulls":3},"immune system process;proteolysis involved in cellular protein catabolic process","threonine-type endopeptidase activity","cytosol;proteasome core complex",{"$nulls":3},1,1,1,"7.6","7.6","7.6","13.919","0.00075529","2.8544",33314000,5,"0.361856","0.667974","9.19076","0.969286","tr|A2ACR0|A2ACR0_HUMAN;tr|A0A0G2JJQ0|A0A0G2JJQ0_HUMAN;tr|A2ACR1|A2ACR1_HUMAN;tr|A0A0G2JJA7|A0A0G2JJA7_HUMAN;sp|P28065|PSB9_HUMAN","tr|A2ACR0|A2ACR0_HUMAN;tr|A0A0G2JJQ0|A0A0G2JJQ0_HUMAN;tr|A2ACR1|A2ACR1_HUMAN;tr|A0A0G2JJA7|A0A0G2JJA7_HUMAN;sp|P28065|PSB9_HUMAN",831,"A2ACR0","A2ACR0_HUMAN",null,null,"PSMB9"]
["19.9405","18.7729","19.5453",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"8.9","8.9","8.9","20.557","0.00039761","3.323",13414000,1,"0.365201","0.663703","9.08406","0.977726","tr|C9JAG1|C9JAG1_HUMAN;tr|A0A087WW58|A0A087WW58_HUMAN;sp|Q9C0D9|EPT1_HUMAN","tr|C9JAG1|C9JAG1_HUMAN;tr|A0A087WW58|A0A087WW58_HUMAN;sp|Q9C0D9|EPT1_HUMAN",2532,"C9JAG1","C9JAG1_HUMAN",null,null,"SELENOI"]
["20.4483","19.2619","20.6382",1,{"$nulls":9},1,1,1,"29.4","29.4","29.4","5.6232",0,"18.596",13165000,4,"0.341713","0.695035","9.03601","0.918573","tr|C9JEF4|C9JEF4_HUMAN;tr|C9J172|C9J172_HUMAN;tr|E9PEH1|E9PEH1_HUMAN;tr|E7EP63|E7EP63_HUMAN;tr|E7ER52|E7ER52_HUMAN;tr|A6NDI8|A6NDI8_HUMAN;tr|E7EPS2|E7EPS2_HUMAN;sp|Q9UBN7|HDAC6_HUMAN","tr|C9JEF4|C9JEF4_HUMAN;tr|C9J172|C9J172_HUMAN;tr|E9PEH1|E9PEH1_HUMAN;tr|E7EP63|E7EP63_HUMAN;tr|E7ER52|E7ER52_HUMAN;tr|A6NDI8|A6NDI8_HUMAN;tr|E7EPS2|E7EPS2_HUMAN;sp|Q9UBN7|HDAC6_HUMAN",2803,"C9JEF4","C9JEF4_HUMAN",null,null,"HDAC6"]
["19.5386","19.0688",1,"19.7747",{"$nulls":3},"protein folding;response to stress","ATP binding;unfolded protein binding","cytoplasm;extracellular exosome",{"$nulls":3},8,1,1,"19.2","3.9","3.9","44.348",0,"21.437",208510000,23,"0.354015","0.681781","8.91634","0.949526","sp|Q58FF8|H90B2_HUMAN","sp|Q58FF8|H90B2_HUMAN",1801,"Q58FF8","H90B2_HUMAN","Putative heat shock protein HSP 90-beta 2",null,"HSP90AB2P"]
["19.2106","19.2455",1,"19.703",{"$nulls":3},"cellular protein modification process;tail-anchored membrane protein insertion into ER membrane","chaperone binding;ubiquitin-like protein transferase activity","BAT3 complex;cytoplasm;cytosol;membrane;nucleus",{"$nulls":3},1,1,1,"6.4","6.4","6.4","17.776","0.0056742","1.869",51438000,1,"0.353888","0.682539","8.87651","0.949205","sp|P11441|UBL4A_HUMAN;tr|Q5HY81|Q5HY81_HUMAN","sp|P11441|UBL4A_HUMAN;tr|Q5HY81|Q5HY81_HUMAN",632,"P11441","UBL4A_HUMAN","Ubiquitin-like protein 4A",null,"UBL4A"]
["17.4947","18.8023",1,"17.6408",{"$nulls":3},"ubiquitin-dependent protein catabolic process",{"$nulls":5},2,2,2,"15.7","15.7","15.7","17.553","0.0010669","2.3736",22931000,6,"0.3968","0.62357","8.8281","1.05776","tr|C9JNP9|C9JNP9_HUMAN;sp|Q92890|UFD1_HUMAN;tr|C9J6N9|C9J6N9_HUMAN;tr|C9IZG3|C9IZG3_HUMAN","tr|C9JNP9|C9JNP9_HUMAN;sp|Q92890|UFD1_HUMAN;tr|C9J6N9|C9J6N9_HUMAN;tr|C9IZG3|C9IZG3_HUMAN",2200,"C9JNP9","C9JNP9_HUMAN",null,null,"UFD1"]
["17.5433","17.6806",1,"16.803",{"$nulls":3},"apoptotic process;mRNA splicing, via spliceosome;positive regulation of apoptotic process;somatic diversification of immunoglobulins","enzyme binding","cytoplasm;membrane;nucleoplasm;nucleus;Prp19 complex;spliceosomal complex","Spliceosome",null,null,2,2,2,"6.6","6.6","6.6","65.173","0.0014109","2.3213",38705000,4,"0.414283","0.600294","8.71045","1.10234","sp|Q8WYA6|CTBL1_HUMAN;tr|A0A087WUB9|A0A087WUB9_HUMAN;tr|A2A2P1|A2A2P1_HUMAN","sp|Q8WYA6|CTBL1_HUMAN;tr|A0A087WUB9|A0A087WUB9_HUMAN;tr|A2A2P1|A2A2P1_HUMAN",2161,"Q8WYA6","CTBL1_HUMAN","Beta-catenin-like protein 1",null,"CTNNBL1"]
["18.6967","18.3681",1,"18.6707",{"$nulls":4},"acylglycerol lipase activity",{"$nulls":4},1,1,1,"11.4","11.4","11.4","11.797","0.0010684","2.3832",14824000,2,"0.367758","0.660081","8.69706","0.984178","tr|I3L440|I3L440_HUMAN;tr|I3L294|I3L294_HUMAN;tr|Q5T712|Q5T712_HUMAN;sp|Q8N2K0|ABD12_HUMAN","tr|I3L440|I3L440_HUMAN;tr|I3L294|I3L294_HUMAN;tr|Q5T712|Q5T712_HUMAN;sp|Q8N2K0|ABD12_HUMAN",2041,"I3L440","I3L440_HUMAN",null,null,"ABHD12"]
["18.1756","18.8517",1,"18.7048",{"$nulls":9},1,1,1,"5.6","5.6","5.6","25.247","0.0075534","1.7502",27775000,3,"0.365187","0.663312","8.66121","0.977689","sp|Q6ZQT7|YJ013_HUMAN","sp|Q6ZQT7|YJ013_HUMAN",1915,"Q6ZQT7","YJ013_HUMAN","Putative uncharacterized protein FLJ44672"]
["18.4199","18.5746","18.8193",1,{"$nulls":4},"aminopeptidase activity;manganese ion binding;metalloexopeptidase activity","cytoplasm;nucleus",{"$nulls":3},1,1,1,"2.3","2.3","2.3","55.86",0,"42.673",38285000,5,"0.359689","0.669375","8.58761","0.963821","sp|Q8NDH3|PEPL1_HUMAN","sp|Q8NDH3|PEPL1_HUMAN",2089,"Q8NDH3","PEPL1_HUMAN","Probable aminopeptidase NPEPL1",null,"NPEPL1"]
["17.8564","17.7327",1,"17.496",{"$nulls":3},"positive regulation of apoptotic process;positive regulation of lipid kinase activity;regulation of chaperone-mediated autophagy;response to electrical stimulus;response to inorganic substance","GTP binding;GTPase activity;protein kinase binding;translation elongation factor activity;translation factor activity, RNA binding","cytoplasm;cytoplasmic side of lysosomal membrane;eukaryotic translation elongation factor 1 complex;myelin sheath;neuronal cell body","Legionellosis;RNA transport",null,null,11,3,3,"33.9","17.5","17.5","50.47",0,"40.721",46727000,3,"0.3883","0.635352","8.54656","1.03617","sp|Q05639|EF1A2_HUMAN","sp|Q05639|EF1A2_HUMAN",1453,"Q05639","EF1A2_HUMAN","Elongation factor 1-alpha 2","F-1-alpha-2","EEF1A2"]
["18.6543","18.5282",1,"19.1654",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;mitochondrial respiratory chain complex III assembly","ubiquinol-cytochrome-c reductase activity","extracellular exosome;mitochondrial inner membrane;mitochondrial respiratory chain complex III","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,1,1,1,27,27,27,"7.3084","0.00039541","3.2955",15565000,4,"0.348947","0.68693","8.50857","0.936768","sp|Q9UDW1|QCR9_HUMAN","sp|Q9UDW1|QCR9_HUMAN",2815,"Q9UDW1","QCR9_HUMAN","Cytochrome b-c1 complex subunit 9",null,"UQCR10"]
["17.2179","17.2606",1,"16.6125",{"$nulls":4},"microtubule binding","cytoplasm;microtubule",{"$nulls":3},1,1,1,"4.4","4.4","4.4","35.671","0.0010672","2.3794",10240000,2,"0.405643","0.613946","8.43297","1.08028","tr|I3L170|I3L170_HUMAN;tr|A0A0G2JQJ7|A0A0G2JQJ7_HUMAN;tr|A0A0G2JPD5|A0A0G2JPD5_HUMAN;sp|P10636|TAU_HUMAN;tr|A0A0G2JS76|A0A0G2JS76_HUMAN;tr|A0A0G2JMX7|A0A0G2JMX7_HUMAN","tr|I3L170|I3L170_HUMAN;tr|A0A0G2JQJ7|A0A0G2JQJ7_HUMAN;tr|A0A0G2JPD5|A0A0G2JPD5_HUMAN;sp|P10636|TAU_HUMAN;tr|A0A0G2JS76|A0A0G2JS76_HUMAN;tr|A0A0G2JMX7|A0A0G2JMX7_HUMAN",610,"I3L170","I3L170_HUMAN","Microtubule-associated protein {ECO:0000256|RuleBase:RU000686}",null,"MAPT"]
["18.2937","18.0096","18.4753",1,{"$nulls":3},"Ras protein signal transduction","GTP binding;GTPase activity","intracellular;plasma membrane",{"$nulls":3},2,1,1,15,"8.4","8.4","18.73","0.0047474","1.9871",12640000,2,"0.359297","0.669055","8.414","0.962833","tr|C9J6B1|C9J6B1_HUMAN;sp|P11234|RALB_HUMAN","tr|C9J6B1|C9J6B1_HUMAN;sp|P11234|RALB_HUMAN",625,"C9J6B1","C9J6B1_HUMAN",null,null,"RALB"]
["18.8751","18.4785","19.5567",1,{"$nulls":9},1,1,1,"10.9","10.9","10.9","14.437",0,"9.6205",26299000,3,"0.336297","0.6975","8.39849","0.904964","tr|C9IYL4|C9IYL4_HUMAN;sp|P29083|T2EA_HUMAN","tr|C9IYL4|C9IYL4_HUMAN;sp|P29083|T2EA_HUMAN",841,"C9IYL4","C9IYL4_HUMAN",null,null,"GTF2E1"]
["17.2216","16.7758",1,"16.2183",{"$nulls":3},"AMPA glutamate receptor clustering;amyloid precursor protein metabolic process;artery morphogenesis;cellular calcium ion homeostasis;cellular protein metabolic process;cGMP-mediated signaling;cholesterol catabolic process;cholesterol efflux;cholesterol homeostasis;cholesterol metabolic process;chylomicron assembly;chylomicron remnant clearance;chylomicron remodeling;cytoskeleton organization;fatty acid homeostasis;G-protein coupled receptor signaling pathway;high-density lipoprotein particle assembly;high-density lipoprotein particle clearance;high-density lipoprotein particle remodeling;intracellular transport;lipid transport involved in lipid storage;lipoprotein biosynthetic process;lipoprotein catabolic process;locomotory exploration behavior;long-chain fatty acid transport;long-term memory;low-density lipoprotein particle remodeling;maintenance of location in cell;negative regulation of amyloid-beta formation;negative regulation of blood coagulation;negative regulation of blood vessel endothelial cell migration;negative regulation of canonical Wnt signaling pathway;negative regulation of cellular protein metabolic process;negative regulation of cholesterol biosynthetic process;negative regulation of cholesterol efflux;negative regulation of dendritic spine development;negative regulation of dendritic spine maintenance;negative regulation of endothelial cell proliferation;negative regulation of inflammatory response;negative regulation of lipid biosynthetic process;negative regulation of lipid transport across blood brain barrier;negative regulation of long-term synaptic potentiation;negative regulation of MAP kinase activity;negative regulation of neuron apoptotic process;negative regulation of neuron death;negative regulation of neuron projection development;negative regulation of phospholipid efflux;negative regulation of platelet activation;negative regulation of postsynaptic membrane organization;negative regulation of presynaptic membrane organization;negative regulation of triglyceride metabolic process;neuron projection regeneration;nitric oxide mediated signal transduction;NMDA glutamate receptor clustering;phospholipid efflux;positive regulation by host of viral process;positive regulation of amyloid fibril formation;positive regulation of amyloid-beta formation;positive regulation of cGMP biosynthetic process;positive regulation of cholesterol efflux;positive regulation of cholesterol esterification;positive regulation of dendritic spine development;positive regulation of dendritic spine maintenance;positive regulation of endocytosis;positive regulation of heparan sulfate binding;positive regulation of heparan sulfate proteoglycan binding;positive regulation of lipid biosynthetic process;positive regulation of lipid transport across blood brain barrier;positive regulation of low-density lipoprotein particle receptor catabolic process;positive regulation of membrane protein ectodomain proteolysis;positive regulation of neurofibrillary tangle assembly;positive regulation of neuron death;positive regulation of neuron projection development;positive regulation of nitric-oxide synthase activity;positive regulation of phospholipid efflux;positive regulation of postsynaptic membrane organization;positive regulation of presynaptic membrane organization;post-translational protein modification;protein import;receptor-mediated endocytosis;regulation of amyloid fibril formation;regulation of amyloid-beta clearance;regulation of axon extension;regulation of behavioral fear response;regulation of Cdc42 protein signal transduction;regulation of cellular response to very-low-density lipoprotein particle stimulus;regulation of cholesterol metabolic process;regulation of neuron death;regulation of neuronal synaptic plasticity;regulation of protein homooligomerization;regulation of protein metabolic process;regulation of tau-protein kinase activity;regulation of transcription from RNA polymerase II promoter;response to caloric restriction;response to dietary excess;response to reactive oxygen species;retinoid metabolic process;reverse cholesterol transport;synaptic transmission, cholinergic;triglyceride catabolic process;triglyceride homeostasis;triglyceride metabolic process;vasodilation;very-low-density lipoprotein particle clearance;very-low-density lipoprotein particle remodeling;virion assembly","amyloid-beta binding;antioxidant activity;cholesterol binding;cholesterol transporter activity;heparin binding;identical protein binding;lipid binding;lipid transporter activity;lipoprotein particle binding;low-density lipoprotein particle receptor binding;metal chelating activity;phosphatidylcholine-sterol O-acyltransferase activator activity;phospholipid binding;protein dimerization activity;protein homodimerization activity;structural molecule activity;tau protein binding;very-low-density lipoprotein particle receptor binding","blood microparticle;chylomicron;clathrin-coated endocytic vesicle membrane;cytoplasm;dendrite;discoidal high-density lipoprotein particle;early endosome;endocytic vesicle lumen;endoplasmic reticulum;endoplasmic reticulum lumen;extracellular exosome;extracellular matrix;extracellular region;extracellular space;extracellular vesicle;Golgi apparatus;high-density lipoprotein particle;intermediate-density lipoprotein particle;lipoprotein particle;low-density lipoprotein particle;membrane;neuronal cell body;nucleus;plasma membrane;very-low-density lipoprotein particle","Alzheimer disease;Cholesterol metabolism",null,null,1,1,1,"2.8","2.8","2.8","36.154",0,"4.8123",11012000,3,"0.414184","0.599893","8.38955","1.10209","sp|P02649|APOE_HUMAN","sp|P02649|APOE_HUMAN",481,"P02649","APOE_HUMAN","Apolipoprotein E","po-E","APOE"]
["18.2453","18.4101","18.9461",1,{"$nulls":3},"Golgi organization",{"$nulls":5},1,1,1,"11.1","11.1","11.1","12.736",0,"5.6528",29291000,5,"0.346672","0.687937","8.35466","0.931043","tr|H0YK03|H0YK03_HUMAN;sp|Q8TBA6|GOGA5_HUMAN","tr|H0YK03|H0YK03_HUMAN;sp|Q8TBA6|GOGA5_HUMAN",2111,"H0YK03","H0YK03_HUMAN",null,null,"GOLGA5"]
["17.5669","17.3312","17.2534",1,{"$nulls":3},"adherens junction maintenance",{"$nulls":5},1,1,1,"6.2","6.2","6.2","23.945",0,"3.5115",11769000,4,"0.383488","0.636145","8.32236","1.02397","tr|H0YG85|H0YG85_HUMAN;sp|Q8NHQ8|RASF8_HUMAN","tr|H0YG85|H0YG85_HUMAN;sp|Q8NHQ8|RASF8_HUMAN",2102,"H0YG85","H0YG85_HUMAN",null,null,"RASSF8"]
["17.75","17.3379","17.4708",1,{"$nulls":3},"alternative mRNA splicing, via spliceosome;mRNA 3'-end processing;mRNA export from nucleus;mRNA splice site selection;mRNA splicing, via spliceosome;negative regulation of cell death;negative regulation of keratinocyte differentiation;negative regulation of mRNA splicing, via spliceosome;negative regulation of type B pancreatic cell apoptotic process;positive regulation of epithelial cell proliferation involved in lung morphogenesis;regulation of alternative mRNA splicing, via spliceosome;regulation of keratinocyte proliferation;regulation of wound healing;response to insulin;RNA export from nucleus;termination of RNA polymerase II transcription","pre-mRNA binding;RNA binding","nuclear speck;nucleoplasm","Herpes simplex virus 1 infection;Spliceosome",null,null,2,1,1,"5.2","2.6","2.6","39.586","0.0034376","2.083",22560000,2,"0.377406","0.645566","8.30855","1.00857","sp|Q13247|SRSF6_HUMAN","sp|Q13247|SRSF6_HUMAN",1536,"Q13247","SRSF6_HUMAN","Serine/arginine-rich splicing factor 6",null,"SRSF6"]
["18.0555","17.7902","18.2899",1,{"$nulls":3},"tricarboxylic acid cycle","oxoglutarate dehydrogenase (succinyl-transferring) activity;thiamine pyrophosphate binding",{"$nulls":4},1,1,1,10,10,10,"18.157","0.00039777","3.3312",10813000,5,"0.35715","0.67594","8.27786","0.957424","tr|H7C1J3|H7C1J3_HUMAN;tr|C9JWN1|C9JWN1_HUMAN;sp|Q96HY7|DHTK1_HUMAN","tr|H7C1J3|H7C1J3_HUMAN;tr|C9JWN1|C9JWN1_HUMAN;sp|Q96HY7|DHTK1_HUMAN",2291,"H7C1J3","H7C1J3_HUMAN",null,null,"DHTKD1"]
["18.1511","17.6774","18.4695",1,{"$nulls":9},1,1,1,"5.1","5.1","5.1","24.259","0.0047554","2.0029",30016000,0,"0.348677","0.686536","8.17949","0.936088","tr|C9JJ54|C9JJ54_HUMAN;sp|Q8IWB7|WDFY1_HUMAN","tr|C9JJ54|C9JJ54_HUMAN;sp|Q8IWB7|WDFY1_HUMAN",2012,"C9JJ54","C9JJ54_HUMAN",null,null,"WDFY1"]
["16.8549","17.2912","16.8209",1,{"$nulls":3},"COPII vesicle coating;ER to Golgi vesicle-mediated transport;Golgi organization;intracellular protein transport","metal ion binding;phospholipase activity;RNA binding","COPII-coated ER to Golgi transport vesicle;cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle",{"$nulls":3},2,2,2,"3.9","3.9","3.9","111.08","0.0097498","1.6744",37215000,4,"0.386453","0.633943","8.16261","1.03148","sp|Q9Y6Y8|S23IP_HUMAN;tr|A0A0C4DH82|A0A0C4DH82_HUMAN","sp|Q9Y6Y8|S23IP_HUMAN;tr|A0A0C4DH82|A0A0C4DH82_HUMAN",3058,"Q9Y6Y8","S23IP_HUMAN","SEC23-interacting protein",null,"SEC23IP"]
["16.8627","17.1969",1,"16.7562",{"$nulls":3},"endosomal transport;macroautophagy;multivesicular body assembly;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;regulation of transcription, DNA-templated;transcription, DNA-templated","phosphatidylinositol-3-phosphate binding;protein C-terminus binding;ubiquitin binding","cytosol;endosome;ESCRT II complex;extracellular exosome;late endosome membrane;lysosome;nucleus","Endocytosis",null,null,1,1,1,"2.8","2.8","2.8","43.816",0,"4.9632",31899000,2,"0.387642","0.633536","8.1517","1.0345","sp|Q86VN1|VPS36_HUMAN","sp|Q86VN1|VPS36_HUMAN",1988,"Q86VN1","VPS36_HUMAN","Vacuolar protein-sorting-associated protein 36",null,"VPS36"]
["16.9022","17.1557",1,"16.755",{"$nulls":3},"regulation of inflammatory response;regulation of transcription, DNA-templated",{"$nulls":5},1,1,1,1,1,1,"149.09","0.0027836","2.2064",81735000,4,"0.387699","0.634329","8.15145","1.03464","tr|K7ES28|K7ES28_HUMAN;sp|Q9Y2G9|SBNO2_HUMAN;sp|A3KN83|SBNO1_HUMAN","tr|K7ES28|K7ES28_HUMAN;sp|Q9Y2G9|SBNO2_HUMAN;sp|A3KN83|SBNO1_HUMAN",99,"K7ES28","K7ES28_HUMAN",null,null,"SBNO2"]
["17.3446","16.8291",1,"16.8868",{"$nulls":5},"lipid droplet",{"$nulls":3},1,1,1,7,7,7,"28.102","0.0011136","2.7482",24029000,7,"0.383755","0.63693","8.14343","1.02464","tr|D6RCD0|D6RCD0_HUMAN;sp|Q8NBQ5|DHB11_HUMAN","tr|D6RCD0|D6RCD0_HUMAN;sp|Q8NBQ5|DHB11_HUMAN",2076,"D6RCD0","D6RCD0_HUMAN",null,null,"HSD17B11"]
["16.6568","16.874","16.3715",1,{"$nulls":9},1,1,1,"5.5","5.5","5.5","27.327",0,"3.6552",10215000,5,"0.394199","0.623603","8.07965","1.05115","tr|A2AB09|A2AB09_HUMAN;sp|O75955|FLOT1_HUMAN","tr|A2AB09|A2AB09_HUMAN;sp|O75955|FLOT1_HUMAN",380,"A2AB09","A2AB09_HUMAN",null,null,"FLOT1"]
["17.864","17.9092","18.6653",1,{"$nulls":9},1,1,1,"13.9","13.9","13.9","12.951","0.00040193","3.4005",13034000,5,"0.339033","0.69795","8.05397","0.911839","tr|K7ENH7|K7ENH7_HUMAN;tr|I3L3A9|I3L3A9_HUMAN;tr|I3L355|I3L355_HUMAN;tr|K7ELM2|K7ELM2_HUMAN;tr|K7EKV2|K7EKV2_HUMAN;tr|I3L176|I3L176_HUMAN;tr|I3L421|I3L421_HUMAN;tr|I3L1W8|I3L1W8_HUMAN;sp|Q86US8|EST1A_HUMAN","tr|K7ENH7|K7ENH7_HUMAN;tr|I3L3A9|I3L3A9_HUMAN;tr|I3L355|I3L355_HUMAN;tr|K7ELM2|K7ELM2_HUMAN;tr|K7EKV2|K7EKV2_HUMAN;tr|I3L176|I3L176_HUMAN;tr|I3L421|I3L421_HUMAN;tr|I3L1W8|I3L1W8_HUMAN;sp|Q86US8|EST1A_HUMAN",1980,"K7ENH7","K7ENH7_HUMAN",null,null,"SMG6"]
["16.2797","16.8812","16.0567",1,{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K11-linked ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle","protein phosphatase binding","anaphase-promoting complex;cytosol;nucleoplasm;nucleus","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis",null,null,1,1,1,2,2,2,"66.855",0,"5.6932",18032000,3,"0.401105","0.621387","8.05209","1.06872","sp|Q9UJX3|APC7_HUMAN","sp|Q9UJX3|APC7_HUMAN",2862,"Q9UJX3","APC7_HUMAN","Anaphase-promoting complex subunit 7","PC7","ANAPC7"]
["17.0526","15.977",1,"15.9875",{"$nulls":4},"peptidyl-prolyl cis-trans isomerase activity","nuclear body",{"$nulls":3},2,2,2,"4.1","4.1","4.1","70.276","0.0047345","1.9566",12431000,3,"0.400676","0.62118","8.02107","1.06762","tr|F5H7P7|F5H7P7_HUMAN;sp|Q96BP3|PPWD1_HUMAN","tr|F5H7P7|F5H7P7_HUMAN;sp|Q96BP3|PPWD1_HUMAN",2239,"F5H7P7","F5H7P7_HUMAN",null,null,"PPWD1"]
["17.6083","17.2677","17.85",1,{"$nulls":3},"acyl-CoA metabolic process;medium-chain fatty acid biosynthetic process;short-chain fatty acid biosynthetic process","3-oxoacyl-[acyl-carrier-protein] synthase activity","cytosol;mitochondrion","Biotin metabolism;Fatty acid biosynthesis;Fatty acid metabolism;Metabolic pathways",null,null,1,1,1,"6.1","6.1","6.1","48.842",0,"3.6684",20841000,4,"0.354565","0.681022","8.01303","0.950909","sp|Q9NWU1|OXSM_HUMAN","sp|Q9NWU1|OXSM_HUMAN",2727,"Q9NWU1","OXSM_HUMAN","3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial",null,"OXSM"]
["18.4505","17.8163","19.3005",1,{"$nulls":3},"regulation of response to reactive oxygen species",null,"nucleus",{"$nulls":3},1,1,1,"15.7","15.7","15.7","8.102",0,"5.6218",9320800,2,"0.323136","0.708234","7.98314","0.871925","tr|F5H1K7|F5H1K7_HUMAN;sp|P58005|SESN3_HUMAN","tr|F5H1K7|F5H1K7_HUMAN;sp|P58005|SESN3_HUMAN",1231,"F5H1K7","F5H1K7_HUMAN",null,null,"SESN3"]
["16.5137","17.3006",1,"16.8803",{"$nulls":3},"tRNA-type intron splice site recognition and cleavage","tRNA-intron endonuclease activity","nucleus;tRNA-intron endonuclease complex",{"$nulls":3},1,1,1,"8.3","8.3","8.3","26.101",0,"52.481",18798000,7,"0.37487","0.650081","7.96701","1.00215","tr|B0V3J0|B0V3J0_HUMAN;tr|A9C4B9|A9C4B9_HUMAN;tr|A0A0G2JNK5|A0A0G2JNK5_HUMAN;tr|A0A024R4N9|A0A024R4N9_HUMAN;sp|Q9BSV6|SEN34_HUMAN;tr|E7EQB3|E7EQB3_HUMAN","tr|B0V3J0|B0V3J0_HUMAN;tr|A9C4B9|A9C4B9_HUMAN;tr|A0A0G2JNK5|A0A0G2JNK5_HUMAN;tr|A0A024R4N9|A0A024R4N9_HUMAN;sp|Q9BSV6|SEN34_HUMAN;tr|E7EQB3|E7EQB3_HUMAN",2439,"B0V3J0","B0V3J0_HUMAN",null,null,"TSEN34"]
["17.8701","17.5943",1,"18.5426",{"$nulls":4},"protein serine/threonine phosphatase activity",{"$nulls":4},1,1,1,"3.9","3.9","3.9","22.883","0.0097624","1.6863",27366000,2,"0.337302","0.697372","7.96085","0.907488","tr|H7C2I8|H7C2I8_HUMAN;tr|E9PC05|E9PC05_HUMAN;tr|F8SNU7|F8SNU7_HUMAN;sp|Q9H0C8|ILKAP_HUMAN","tr|H7C2I8|H7C2I8_HUMAN;tr|E9PC05|E9PC05_HUMAN;tr|F8SNU7|F8SNU7_HUMAN;sp|Q9H0C8|ILKAP_HUMAN",2556,"H7C2I8","H7C2I8_HUMAN",null,null,"ILKAP"]
["18.161","16.9061","18.1787",1,{"$nulls":9},2,2,2,"4.3","4.3","4.3","69.8","0.0047733","2.0275",69417000,2,"0.343244","0.691379","7.94415","0.922424","tr|B8ZZW5|B8ZZW5_HUMAN;sp|Q8NBF6|AVL9_HUMAN;tr|H7C0I1|H7C0I1_HUMAN","tr|B8ZZW5|B8ZZW5_HUMAN;sp|Q8NBF6|AVL9_HUMAN;tr|H7C0I1|H7C0I1_HUMAN",2070,"B8ZZW5","B8ZZW5_HUMAN",null,null,"AVL9"]
["16.0683","15.7318",1,"14.9331",{"$nulls":3},"cell differentiation;multicellular organism development;negative regulation of transcription, DNA-templated","transcription corepressor activity","cytosol;microtubule;nucleus",{"$nulls":3},2,2,2,"3.8","3.8","3.8","80.642","0.0013996","2.2536",12939000,1,"0.42838","0.584341","7.93352","1.13847","sp|Q96AQ6|PBIP1_HUMAN","sp|Q96AQ6|PBIP1_HUMAN",2233,"Q96AQ6","PBIP1_HUMAN","Pre-B-cell leukemia transcription factor-interacting protein 1",null,"PBXIP1"]
["17.4916","17.189","17.8784",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"20.2","20.2","20.2","10.144","0.0011054","2.6901",4729100,1,"0.348676","0.686147","7.9011","0.936086","tr|M0R0K7|M0R0K7_HUMAN;tr|M0R0H0|M0R0H0_HUMAN;tr|M0R0A9|M0R0A9_HUMAN;sp|P55899|FCGRN_HUMAN","tr|M0R0K7|M0R0K7_HUMAN;tr|M0R0H0|M0R0H0_HUMAN;tr|M0R0A9|M0R0A9_HUMAN;sp|P55899|FCGRN_HUMAN",1217,"M0R0K7","M0R0K7_HUMAN",null,null,"FCGRT"]
["15.8107","16.2461",1,"15.3687",{"$nulls":5},"Golgi apparatus",{"$nulls":3},1,1,1,3,3,3,"63.286","0.0047377","1.9597",8209100,4,"0.409972","0.608403","7.84405","1.09132","tr|E9PGE5|E9PGE5_HUMAN;sp|Q9NUY8|TBC23_HUMAN","tr|E9PGE5|E9PGE5_HUMAN;sp|Q9NUY8|TBC23_HUMAN",2714,"E9PGE5","E9PGE5_HUMAN",null,null,"TBC1D23"]
["17.3018","16.6774",1,"17.3559",{"$nulls":3},"histone H3-K4 methylation;histone H3-K4 trimethylation","chromatin binding","chromatin;histone methyltransferase complex;nucleolus;PTW/PP1 phosphatase complex;Set1C/COMPASS complex","mRNA surveillance pathway",null,null,2,2,2,"10.9","10.9","10.9","35.079",0,"7.773",12220000,3,"0.355997","0.677427","7.81168","0.954519","sp|Q6UXN9|WDR82_HUMAN","sp|Q6UXN9|WDR82_HUMAN",1905,"Q6UXN9","WDR82_HUMAN","WD repeat-containing protein 82",null,"WDR82"]
["17.6612","17.9759",1,"19.1352",{"$nulls":9},1,1,1,"4.2","4.2","4.2","49.374",0,"39.893",48006000,5,"0.316258","0.713244","7.75101","0.854676","tr|E9PJ60|E9PJ60_HUMAN;sp|Q9UHI6|DDX20_HUMAN","tr|E9PJ60|E9PJ60_HUMAN;sp|Q9UHI6|DDX20_HUMAN",2834,"E9PJ60","E9PJ60_HUMAN",null,null,"DDX20"]
["17.0567","16.3917","16.9988",1,{"$nulls":3},"ubiquitin-dependent protein catabolic process","transcription factor binding","cytosol;nucleoplasm;proteasome regulatory particle, base subcomplex",{"$nulls":3},6,1,1,"24.2","7.4","7.4","41.079","0.00039108","3.1739",12684000,4,"0.360096","0.667967","7.72485","0.964847","tr|Q5VWC4|Q5VWC4_HUMAN;tr|A6PVX3|A6PVX3_HUMAN;sp|A2A3N6|PIPSL_HUMAN;tr|H0Y561|H0Y561_HUMAN","tr|Q5VWC4|Q5VWC4_HUMAN;tr|A6PVX3|A6PVX3_HUMAN",3117,"Q5VWC4","Q5VWC4_HUMAN"]
["17.5422","16.9078","18.0219",1,{"$nulls":4},"oxidoreductase activity","endoplasmic reticulum;mitochondrial inner membrane",{"$nulls":3},1,1,1,"4.5","4.5","4.5","33.909","0.0010612","2.3468",28612000,2,"0.336603","0.697369","7.71402","0.905734","sp|Q96LJ7|DHRS1_HUMAN","sp|Q96LJ7|DHRS1_HUMAN",2324,"Q96LJ7","DHRS1_HUMAN","Dehydrogenase/reductase SDR family member 1",null,"DHRS1"]
["16.3888","15.5086",1,"15.4899",{"$nulls":3},"calcium-independent cell-matrix adhesion;protein homooligomerization;regulation of insulin receptor signaling pathway","calcium ion binding;identical protein binding","basement membrane;extracellular exosome;extracellular space",{"$nulls":3},1,1,1,"3.4","3.4","3.4","82.011","0.0031024","2.1232",7662100,3,"0.398219","0.623218","7.70374","1.06137","sp|Q5GFL6|VWA2_HUMAN","sp|Q5GFL6|VWA2_HUMAN",1806,"Q5GFL6","VWA2_HUMAN","von Willebrand factor A domain-containing protein 2",null,"VWA2"]
["16.3989","16.6763",1,"16.7013",{"$nulls":3},"extrinsic apoptotic signaling pathway;intrinsic apoptotic signaling pathway;sphinganine-1-phosphate metabolic process;sphingolipid biosynthetic process;sphingosine metabolic process","dihydrosphingosine-1-phosphate phosphatase activity;sphingosine-1-phosphate phosphatase activity","endoplasmic reticulum membrane;integral component of membrane;plasma membrane","Sphingolipid metabolism;Sphingolipid signaling pathway",null,null,1,1,1,"3.9","3.9","3.9","49.107","0.0011111","2.7257",12472000,1,"0.365706","0.664161","7.68698","0.978998","sp|Q9BX95|SGPP1_HUMAN","sp|Q9BX95|SGPP1_HUMAN",2493,"Q9BX95","SGPP1_HUMAN","Sphingosine-1-phosphate phosphatase 1","pp1;PPase1;SPP1;SPPase1","SGPP1"]
["16.2079","16.6989",1,"16.5701",{"$nulls":3},"cholesterol biosynthetic process;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding transcription factor activity;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;zinc ion binding","cytosol;endoplasmic reticulum;nucleus",{"$nulls":3},1,1,1,"8.5","8.5","8.5","19.463","0.0010753","2.4125",8293300,1,"0.367893","0.660472","7.66835","0.984521","sp|P62633|CNBP_HUMAN","sp|P62633|CNBP_HUMAN",1309,"P62633","CNBP_HUMAN","Cellular nucleic acid-binding protein","NBP","CNBP"]
["17.4322","16.9898",1,"18.1258",{"$nulls":3},"transport","ATP binding;ATPase activity;transporter activity","ATP-binding cassette (ABC) transporter complex;membrane;mitochondrial envelope",{"$nulls":3},3,3,3,"4.5","4.5","4.5","71.289",0,"8.1598",87419000,6,"0.331484","0.702036","7.64815","0.892878","sp|Q9UG63|ABCF2_HUMAN;tr|C9JHK9|C9JHK9_HUMAN;tr|C9JZV3|C9JZV3_HUMAN","sp|Q9UG63|ABCF2_HUMAN;tr|C9JHK9|C9JHK9_HUMAN;tr|C9JZV3|C9JZV3_HUMAN",2821,"Q9UG63","ABCF2_HUMAN","ATP-binding cassette sub-family F member 2",null,"ABCF2"]
["16.0268","17.0179","16.8745",1,{"$nulls":3},"metabolic process","catalytic activity",{"$nulls":4},1,1,1,"6.6","6.6","6.6","19.418","0.0047218","1.9409",5954100,1,"0.355704","0.678504","7.58512","0.95378","tr|D6RF87|D6RF87_HUMAN;tr|E9PF16|E9PF16_HUMAN;sp|Q96CM8|ACSF2_HUMAN","tr|D6RF87|D6RF87_HUMAN;tr|E9PF16|E9PF16_HUMAN;sp|Q96CM8|ACSF2_HUMAN",2247,"D6RF87","D6RF87_HUMAN",null,null,"ACSF2"]
["14.5665","14.3902","12.8575",1,{"$nulls":3},"animal organ morphogenesis;apoptotic process;B cell differentiation;beta-catenin-TCF complex assembly;cellular response to UV;circadian rhythm;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;fat cell differentiation;heart development;histone acetylation;histone H2B acetylation;histone H4 acetylation;internal peptidyl-lysine acetylation;internal protein amino acid acetylation;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;lung development;macrophage derived foam cell differentiation;megakaryocyte development;negative regulation of transcription from RNA polymerase II promoter;nervous system development;Notch signaling pathway;N-terminal peptidyl-lysine acetylation;peptidyl-lysine butyrylation;peptidyl-lysine crotonylation;peptidyl-lysine propionylation;platelet formation;positive regulation by host of viral transcription;positive regulation of DNA binding transcription factor activity;positive regulation of gene expression, epigenetic;positive regulation of protein binding;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response;positive regulation of type I interferon production;protein acetylation;protein destabilization;protein deubiquitination;protein stabilization;regulation of androgen receptor signaling pathway;regulation of autophagy;regulation of cell cycle;regulation of cellular response to heat;regulation of megakaryocyte differentiation;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter in response to hypoxia;regulation of transcription, DNA-templated;regulation of tubulin deacetylation;response to estrogen;response to hypoxia;skeletal muscle tissue development;somitogenesis;stimulatory C-type lectin receptor signaling pathway;transcription-coupled nucleotide-excision repair;viral process","acetyltransferase activity;activating transcription factor binding;androgen receptor binding;beta-catenin binding;chromatin binding;chromatin DNA binding;core promoter binding;damaged DNA binding;DNA binding;histone acetyltransferase activity;histone butyryltransferase activity;histone crotonyltransferase activity;lysine N-acetyltransferase activity, acting on acetyl phosphate as donor;nuclear hormone receptor binding;p53 binding;peptide butyryltransferase activity;peptide N-acetyltransferase activity;peptide-lysine-N-acetyltransferase activity;pre-mRNA intronic binding;protein C-terminus binding;protein propionyltransferase activity;RNA polymerase II activating transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;STAT family protein binding;transcription coactivator activity;transcription factor binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;transferase activity, transferring acyl groups;zinc ion binding","chromosome;cytosol;histone acetyltransferase complex;nucleoplasm;nucleus;transcription factor complex","Adherens junction;cAMP signaling pathway;Cell cycle;FoxO signaling pathway;Glucagon signaling pathway;Hepatitis B;HIF-1 signaling pathway;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term potentiation;Melanogenesis;MicroRNAs in cancer;Notch signaling pathway;Pathways in cancer;Prostate cancer;Renal cell carcinoma;TGF-beta signaling pathway;Thyroid hormone signaling pathway;Tuberculosis;Viral carcinogenesis;Wnt signaling pathway",null,null,1,1,1,1,1,1,"264.16","0.0053548","1.8849",3774200,2,"0.480298","0.52424","7.54959","1.27324","sp|Q09472|EP300_HUMAN","sp|Q09472|EP300_HUMAN",1483,"Q09472","EP300_HUMAN","Histone acetyltransferase p300","300 HAT","EP300"]
["16.8844","16.7511","17.5855",1,{"$nulls":3},"branched-chain amino acid catabolic process;lipid metabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated;valine catabolic process","acyl-CoA dehydrogenase activity;flavin adenine dinucleotide binding","mitochondrial matrix","Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,1,1,1,"2.4","2.4","2.4","45.069","0.00038926","3.1179",18792000,2,"0.337262","0.696986","7.525","0.90739","sp|Q9UKU7|ACAD8_HUMAN","sp|Q9UKU7|ACAD8_HUMAN",2876,"Q9UKU7","ACAD8_HUMAN","Isobutyryl-CoA dehydrogenase, mitochondrial",null,"ACAD8"]
["16.299","16.4589",1,"16.7279",{"$nulls":4},"ATPase activity, coupled to transmembrane movement of substances",{"$nulls":4},1,1,1,"15.5","15.5","15.5","17.422","0.00076046","2.904",13341000,1,"0.356421","0.677318","7.51506","0.955587","tr|G3V2V6|G3V2V6_HUMAN;tr|H0YJH8|H0YJH8_HUMAN;tr|G3V2S6|G3V2S6_HUMAN;sp|Q9Y5K8|VATD_HUMAN","tr|G3V2V6|G3V2V6_HUMAN;tr|H0YJH8|H0YJH8_HUMAN;tr|G3V2S6|G3V2S6_HUMAN;sp|Q9Y5K8|VATD_HUMAN",3019,"G3V2V6","G3V2V6_HUMAN",null,null,"ATP6V1D"]
["16.1601","16.0907","16.3262",1,{"$nulls":3},"collagen catabolic process;endocytosis;osteoblast differentiation","carbohydrate binding;collagen binding;transmembrane signaling receptor activity","focal adhesion;integral component of plasma membrane;membrane","Phagosome;Tuberculosis",null,null,1,1,1,"0.9","0.9","0.9","166.67",0,"47.416",18091000,4,"0.363642","0.66565","7.46233","0.97379","sp|Q9UBG0|MRC2_HUMAN","sp|Q9UBG0|MRC2_HUMAN",2801,"Q9UBG0","MRC2_HUMAN","C-type mannose receptor 2",null,"MRC2"]
["16.8996","16.7267","17.8338",1,{"$nulls":3},"cell cycle;cell division;cell proliferation;chromosome organization;endoderm development;mesenchymal to epithelial transition;nonfunctional rRNA decay;nuclear-transcribed mRNA catabolic process, no-go decay;nuclear-transcribed mRNA catabolic process, non-stop decay;positive regulation of BMP signaling pathway;ribosome disassembly;RNA surveillance;stem cell population maintenance;translation","endonuclease activity;metal ion binding;ribosome binding","cytoplasm;nucleus","mRNA surveillance pathway",null,null,1,1,1,"2.9","2.9","2.9","43.359",0,"5.9205",38682000,5,"0.325831","0.705079","7.39623","0.878689","sp|Q9BRX2|PELO_HUMAN","sp|Q9BRX2|PELO_HUMAN",2431,"Q9BRX2","PELO_HUMAN","Protein pelota homolog",null,"PELO"]
["18.0632","17.4986","19.8233",1,{"$nulls":5},"mitochondrion",{"$nulls":3},2,2,2,"39.9","39.9","39.9","15.627",0,"4.8842",20238000,6,"0.287527","0.743638","7.36928","0.782645","tr|C9JHF5|C9JHF5_HUMAN;sp|Q9GZY8|MFF_HUMAN;tr|C9JU19|C9JU19_HUMAN;tr|A0A0A0MS29|A0A0A0MS29_HUMAN","tr|C9JHF5|C9JHF5_HUMAN;sp|Q9GZY8|MFF_HUMAN;tr|C9JU19|C9JU19_HUMAN;tr|A0A0A0MS29|A0A0A0MS29_HUMAN",2546,"C9JHF5","C9JHF5_HUMAN",null,null,"MFF"]
["16.2768","16.1289",1,"16.6762",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding","nucleoplasm;spliceosomal complex",{"$nulls":3},1,1,1,2,2,2,"72.47","0.0031002","2.115",23366000,1,"0.350061","0.685205","7.36476","0.93957","sp|Q8IWZ8|SUGP1_HUMAN","sp|Q8IWZ8|SUGP1_HUMAN",2019,"Q8IWZ8","SUGP1_HUMAN","SURP and G-patch domain-containing protein 1",null,"SUGP1"]
["16.439","16.6835","17.5331",1,{"$nulls":3},"cytokinesis;mitochondrial respiratory chain complex III assembly;oxidation-reduction process",null,"centrosome;midbody;mitochondrial inner membrane;mitochondrion;respiratory chain",{"$nulls":3},1,1,1,"2.6","2.6","2.6","42.456","0.006327","1.8472",19295000,3,"0.327287","0.704979","7.29471","0.882343","sp|Q6DKK2|TTC19_HUMAN","sp|Q6DKK2|TTC19_HUMAN",1865,"Q6DKK2","TTC19_HUMAN","Tetratricopeptide repeat protein 19, mitochondrial","PR repeat protein 19","TTC19"]
["16.0472","15.7991",1,"16.3815",{"$nulls":3},"tyrosyl-tRNA aminoacylation","ATP binding;tyrosine-tRNA ligase activity","cytoplasm",{"$nulls":3},1,1,1,"4.5","4.5","4.5","32.184",0,"3.7223",11066000,3,"0.35034","0.685207","7.23236","0.940272","tr|H0YHS6|H0YHS6_HUMAN;sp|Q9Y2Z4|SYYM_HUMAN","tr|H0YHS6|H0YHS6_HUMAN;sp|Q9Y2Z4|SYYM_HUMAN",2965,"H0YHS6","H0YHS6_HUMAN","Tyrosine--tRNA ligase {ECO:0000256|RuleBase:RU361234}",null,"YARS2"]
["15.9723","15.5775","16.1268",1,{"$nulls":5},"cytosol;Golgi apparatus;intracellular membrane-bounded organelle;nucleus",{"$nulls":3},1,1,1,"2.1","2.1","2.1","61.488","0.0010866","2.5086",12540000,5,"0.355453","0.680208","7.2115","0.953146","tr|B8ZZI9|B8ZZI9_HUMAN;sp|Q6ULP2|AFTIN_HUMAN","tr|B8ZZI9|B8ZZI9_HUMAN;sp|Q6ULP2|AFTIN_HUMAN",1902,"B8ZZI9","B8ZZI9_HUMAN",null,null,"AFTPH"]
["15.9031","19.6037",1,"20.0975",{"$nulls":3},"cell redox homeostasis;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;negative regulation of protein phosphorylation;positive regulation of ATPase activity;protein folding in endoplasmic reticulum;response to endoplasmic reticulum stress;ubiquitin-dependent ERAD pathway","ATPase activator activity;ATPase binding;chaperone binding;disulfide oxidoreductase activity;Hsp70 protein binding;misfolded protein binding;oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;protein disulfide oxidoreductase activity","endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;membrane","Protein processing in endoplasmic reticulum",null,null,2,2,2,"1.4","1.4","1.4","91.079","0.0010921","2.5443",75019000,4,"0.270822","0.756839","7.20462","0.74073","sp|Q8IXB1|DJC10_HUMAN","sp|Q8IXB1|DJC10_HUMAN",2020,"Q8IXB1","DJC10_HUMAN","DnaJ homolog subfamily C member 10",null,"DNAJC10"]
["15.7788","15.8582","16.3869",1,{"$nulls":3},"cellular response to DNA damage stimulus;copper ion homeostasis;inhibition of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of canonical Wnt signaling pathway;positive regulation of protein linear polyubiquitination;positive regulation of protein ubiquitination;regulation of BMP signaling pathway;regulation of cell proliferation;regulation of inflammatory response;regulation of innate immune response;regulation of nucleotide-binding oligomerization domain containing signaling pathway;Wnt signaling pathway","cysteine-type endopeptidase inhibitor activity involved in apoptotic process;identical protein binding;metal ion binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;nucleoplasm;nucleus","Apoptosis;Apoptosis - multiple species;Focal adhesion;Human T-cell leukemia virus 1 infection;Necroptosis;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Pathways in cancer;Platinum drug resistance;Small cell lung cancer;Toxoplasmosis;Ubiquitin mediated proteolysis",null,null,1,1,1,"2.8","2.8","2.8","56.684","0.00075358","2.8445",13662000,2,"0.344708","0.689563","7.12503","0.926104","sp|P98170|XIAP_HUMAN","sp|P98170|XIAP_HUMAN",1393,"P98170","XIAP_HUMAN","E3 ubiquitin-protein ligase XIAP",null,"XIAP"]
["17.0603","16.8017","18.6588",1,{"$nulls":4},"zinc ion binding","cytosol;plasma membrane",{"$nulls":3},2,2,2,"13.4","13.4","13.4","23.413","0.0007622","2.9303",25051000,3,"0.296137","0.733213","7.10163","0.804231","tr|H7C0Q6|H7C0Q6_HUMAN;sp|Q9C037|TRIM4_HUMAN","tr|H7C0Q6|H7C0Q6_HUMAN;sp|Q9C037|TRIM4_HUMAN",2527,"H7C0Q6","H7C0Q6_HUMAN",null,null,"TRIM4"]
["16.8239","16.8127","18.4359",1,{"$nulls":9},1,1,1,"11.2","11.2","11.2","13.607",0,"5.7141",7474300,2,"0.300212","0.729107","7.10031","0.814447","tr|H0YEI6|H0YEI6_HUMAN;sp|Q8N5D0|WDTC1_HUMAN","tr|H0YEI6|H0YEI6_HUMAN;sp|Q8N5D0|WDTC1_HUMAN",2056,"H0YEI6","H0YEI6_HUMAN",null,null,"WDTC1"]
["15.0447","14.5541",1,"14.4219",{"$nulls":9},1,1,1,"1.5","1.5","1.5","82.063",0,"3.8345",11389000,1,"0.395927","0.623729","7.08843","1.05554","tr|F5GZI3|F5GZI3_HUMAN;tr|Q5VWU8|Q5VWU8_HUMAN;tr|Q5VWV2|Q5VWV2_HUMAN;sp|Q8TEW0|PARD3_HUMAN","tr|F5GZI3|F5GZI3_HUMAN;tr|Q5VWU8|Q5VWU8_HUMAN;tr|Q5VWV2|Q5VWV2_HUMAN;sp|Q8TEW0|PARD3_HUMAN",2129,"F5GZI3","F5GZI3_HUMAN",null,null,"PARD3"]
["16.1845","16.4006",1,"17.4282",{"$nulls":3},"bone resorption;neuron projection development;regulation of neuronal synaptic plasticity",null,"cytosol;dendrite;membrane;neuronal cell body",{"$nulls":3},1,1,1,"1.6","1.6","1.6","78.863",0,"6.4685",38312000,1,"0.319044","0.711165","7.07841","0.861662","sp|Q9UBB6|NCDN_HUMAN","sp|Q9UBB6|NCDN_HUMAN",2797,"Q9UBB6","NCDN_HUMAN","Neurochondrin",null,"NCDN"]
["17.9389","16.0745","18.9446",1,{"$nulls":3},"ciliary basal body-plasma membrane docking;cilium assembly;G2/M transition of mitotic cell cycle;protein polyglutamylation;protein transport;regulation of G2/M transition of mitotic cell cycle",null,"centriole;centrosome;ciliary basal body;cilium;cytosol;membrane",{"$nulls":3},2,2,2,"9.4","9.4","9.4","41.368",0,"11.806",37763000,5,"0.286402","0.744954","7.03446","0.779824","sp|Q9BYV8|CEP41_HUMAN;tr|F8WF85|F8WF85_HUMAN;tr|C9J6R3|C9J6R3_HUMAN;tr|C9J9X8|C9J9X8_HUMAN;tr|C9JCX6|C9JCX6_HUMAN;tr|C9JXA0|C9JXA0_HUMAN","sp|Q9BYV8|CEP41_HUMAN;tr|F8WF85|F8WF85_HUMAN;tr|C9J6R3|C9J6R3_HUMAN;tr|C9J9X8|C9J9X8_HUMAN;tr|C9JCX6|C9JCX6_HUMAN;tr|C9JXA0|C9JXA0_HUMAN",2513,"Q9BYV8","CEP41_HUMAN","Centrosomal protein of 41 kDa","ep41","CEP41"]
["16.5965","15.948","17.4847",1,{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;immune response;interferon-gamma-mediated signaling pathway;regulation of immune response;type I interferon signaling pathway;viral process","peptide antigen binding","cell surface;early endosome membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;integral component of plasma membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},5,2,0,"20.2","6.3",0,"40.885",0,"4.5493",23523000,6,"0.315287","0.713846","7.02989","0.852239","sp|P30508|1C12_HUMAN;sp|Q29960|1C16_HUMAN","sp|P30508|1C12_HUMAN;sp|Q29960|1C16_HUMAN",871,"P30508","1C12_HUMAN","HLA class I histocompatibility antigen, Cw-12 alpha chain",null,"HLA-C"]
["16.5309","15.7221","17.2883",1,{"$nulls":3},"mismatch repair;somatic hypermutation of immunoglobulin genes","ATPase activity;kinase activity;single-stranded DNA binding","MutLalpha complex",{"$nulls":3},1,1,1,"5.2","5.2","5.2","28.554","0.0053818","1.9156",10427000,1,"0.316899","0.713544","6.9823","0.856282","sp|Q13670|PM2PB_HUMAN","sp|Q13670|PM2PB_HUMAN",1584,"Q13670","PM2PB_HUMAN","Putative postmeiotic segregation increased 2-like protein 11",null,"PMS2P11"]
["16.0502","16.8882","17.9755",1,{"$nulls":9},2,2,2,"35.9","35.9","35.9","7.5935","0.00040225","3.4037",15508000,2,"0.303039","0.725581","6.98147","0.821534","tr|F8WBV5|F8WBV5_HUMAN;tr|G3XAJ4|G3XAJ4_HUMAN;tr|F8WCJ3|F8WCJ3_HUMAN;tr|B8ZZX4|B8ZZX4_HUMAN;sp|O14530|TXND9_HUMAN","tr|F8WBV5|F8WBV5_HUMAN;tr|G3XAJ4|G3XAJ4_HUMAN;tr|F8WCJ3|F8WCJ3_HUMAN;tr|B8ZZX4|B8ZZX4_HUMAN;sp|O14530|TXND9_HUMAN",158,"F8WBV5","F8WBV5_HUMAN",null,null,"TXNDC9"]
["13.9376","15.1835","14.2059",1,{"$nulls":3},"cellular response to insulin stimulus;protein localization to plasma membrane;protein transport","Rab guanyl-nucleotide exchange factor activity","cytoplasmic vesicle membrane;cytosol;insulin-responsive compartment;plasma membrane;retromer complex",{"$nulls":3},1,1,1,"1.1","1.1","1.1","217.82","0.0003951","3.2938",12795000,2,"0.393373","0.626856","6.95759","1.04905","tr|R4GN35|R4GN35_HUMAN","tr|R4GN35|R4GN35_HUMAN",3119,"R4GN35","DEN4C_HUMAN","DENN domain-containing protein 4C",null,"DENND4C"]
["15.0363","15.8535","16.0272",1,{"$nulls":3},"exocyst assembly;Golgi to plasma membrane transport;protein transport;regulation of entry of bacterium into host cell","protein kinase binding;protein N-terminus binding;Ral GTPase binding","cytosol;exocyst;Flemming body;membrane;plasma membrane","Ras signaling pathway",null,null,2,2,2,"1.8","1.8","1.8","104.07","0.0010854","2.4993",30538000,2,"0.342735","0.691642","6.93131","0.921142","sp|Q96KP1|EXOC2_HUMAN","sp|Q96KP1|EXOC2_HUMAN",2320,"Q96KP1","EXOC2_HUMAN","Exocyst complex component 2",null,"EXOC2"]
["16.1901","16.0099","17.3472",1,{"$nulls":5},"Golgi apparatus",{"$nulls":3},1,1,1,"6.1","6.1","6.1","44.79",0,"4.4087",20214000,3,"0.313344","0.71418","6.92645","0.847368","tr|F5H1Y4|F5H1Y4_HUMAN;sp|Q9HD26|GOPC_HUMAN","tr|F5H1Y4|F5H1Y4_HUMAN;sp|Q9HD26|GOPC_HUMAN",2649,"F5H1Y4","F5H1Y4_HUMAN"]
["15.6063","15.7483",1,"16.528",{"$nulls":3},"mitochondrial tRNA methylation","tRNA (guanine(37)-N(1))-methyltransferase activity","mitochondrial matrix;nucleus",{"$nulls":3},1,1,1,"2.9","2.9","2.9","58.246","0.0047249","1.9425",17282000,1,"0.330495","0.702896","6.9133","0.890394","sp|Q32P41|TRM5_HUMAN","sp|Q32P41|TRM5_HUMAN",1778,"Q32P41","TRM5_HUMAN","tRNA (guanine(37)-N1)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03152}",null,"TRMT5"]
["15.4885","15.2072","15.8711",1,{"$nulls":3},"acylglycerol catabolic process;long term synaptic depression;negative regulation of cell migration;phospholipid catabolic process;positive regulation of lipid biosynthetic process;regulation of endocannabinoid signaling pathway","acylglycerol lipase activity;phospholipase activity","AMPA glutamate receptor complex;extracellular exosome;integral component of membrane;mitochondrion;plasma membrane","Retrograde endocannabinoid signaling",null,null,2,2,2,"7.4","7.4","7.4","38.33","0.0075733","1.7556",2587200,1,"0.346043","0.688984","6.91229","0.929463","sp|Q9BV23|ABHD6_HUMAN;tr|C9JNE7|C9JNE7_HUMAN;tr|A0A087X2C5|A0A087X2C5_HUMAN","sp|Q9BV23|ABHD6_HUMAN;tr|C9JNE7|C9JNE7_HUMAN;tr|A0A087X2C5|A0A087X2C5_HUMAN",2464,"Q9BV23","ABHD6_HUMAN","Monoacylglycerol lipase ABHD6 {ECO:0000305}",null,"ABHD6"]
["14.8923","15.8589",1,"15.9291",{"$nulls":9},1,1,1,1,1,1,"127.33","0.0097371","1.6715",18124000,1,"0.34384","0.691462","6.91107","0.92392","tr|E9PR16|E9PR16_HUMAN;tr|G3V198|G3V198_HUMAN;sp|Q12769|NU160_HUMAN","tr|E9PR16|E9PR16_HUMAN;tr|G3V198|G3V198_HUMAN;sp|Q12769|NU160_HUMAN",1491,"E9PR16","E9PR16_HUMAN",null,null,"NUP160"]
["14.6212","14.676","14.5722",1,{"$nulls":9},1,1,1,"1.1","1.1","1.1","154.72","0.00039683","3.3155",16871000,5,"0.378465","0.644542","6.86249","1.01125","tr|H7C1J4|H7C1J4_HUMAN;sp|Q6BDS2|URFB1_HUMAN","tr|H7C1J4|H7C1J4_HUMAN;sp|Q6BDS2|URFB1_HUMAN",1862,"H7C1J4","H7C1J4_HUMAN",null,null,"UHRF1BP1"]
["15.0286","15.3385","15.6695",1,{"$nulls":3},"retrograde transport, endosome to Golgi",null,"cytosol;Golgi cisterna membrane;integral component of membrane",{"$nulls":3},1,1,1,"2.9","2.9","2.9","63.429",0,"3.8928",9238700,4,"0.347665","0.687474","6.84882","0.933542","sp|Q8NBN3|TM87A_HUMAN","sp|Q8NBN3|TM87A_HUMAN",2074,"Q8NBN3","TM87A_HUMAN","Transmembrane protein 87A {ECO:0000305}",null,"TMEM87A"]
["15.3562","15.1346","15.8371",1,{"$nulls":5},"cytoplasm;cytosol;integral component of membrane;lysosomal membrane;membrane;microtubule cytoskeleton;nucleus",{"$nulls":3},1,1,1,"0.8","0.8","0.8","136.68",0,"3.5657",23297000,5,"0.342339","0.693236","6.82691","0.920148","sp|Q9BZH6|WDR11_HUMAN","sp|Q9BZH6|WDR11_HUMAN",2520,"Q9BZH6","WDR11_HUMAN","WD repeat-containing protein 11",null,"WDR11"]
["15.6148","15.5908","16.586",1,{"$nulls":5},"cytosol;intracellular membrane-bounded organelle",{"$nulls":3},1,1,1,"2.6","2.6","2.6","54.832","0.0031045","2.1299",18471000,4,"0.323897","0.709132","6.80981","0.873837","tr|E7EX40|E7EX40_HUMAN;sp|Q6WKZ4|RFIP1_HUMAN","tr|E7EX40|E7EX40_HUMAN;sp|Q6WKZ4|RFIP1_HUMAN",1909,"E7EX40","E7EX40_HUMAN",null,null,"RAB11FIP1"]
["14.6813","15.5489",1,"15.7131",{"$nulls":3},"activation of MAPK activity;cell-matrix adhesion;cellular extravasation;extracellular matrix organization;integrin-mediated signaling pathway;muscle contraction;negative regulation of cell proliferation;negative regulation of epidermal growth factor receptor signaling pathway;neuron projection morphogenesis;neutrophil chemotaxis;positive regulation of neuron apoptotic process;positive regulation of phosphoprotein phosphatase activity;vasodilation","collagen binding;collagen binding involved in cell-matrix adhesion;metal ion binding;protein phosphatase binding;receptor binding","acrosomal vesicle;basal part of cell;cell surface;external side of plasma membrane;extracellular exosome;focal adhesion;integrin alpha1-beta1 complex;integrin complex;membrane;membrane raft;neuron projection;perikaryon;plasma membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Hematopoietic cell lineage;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);PI3K-Akt signaling pathway;Regulation of actin cytoskeleton",null,null,2,2,2,"3.6","3.6","3.6","130.85",0,"8.764",15854000,3,"0.341133","0.694259","6.75854","0.917117","sp|P56199|ITA1_HUMAN","sp|P56199|ITA1_HUMAN",1221,"P56199","ITA1_HUMAN","Integrin alpha-1",null,"ITGA1"]
["15.1812","16.5778","17.5064",1,{"$nulls":3},"covalent chromatin modification",null,"chromosome;cytosol;plasma membrane",{"$nulls":3},1,1,1,"3.5","3.5","3.5","40.078","0.0030981","2.1081",8743200,2,"0.294456","0.735246","6.62631","0.800018","sp|A6NED2|RCCD1_HUMAN","sp|A6NED2|RCCD1_HUMAN",103,"A6NED2","RCCD1_HUMAN","RCC1 domain-containing protein 1",null,"RCCD1"]
["15.9654","15.8151","17.5383",1,{"$nulls":3},"attachment of spindle microtubules to kinetochore;cell division;chromosome segregation;mitotic cell cycle;mitotic spindle assembly;protein deubiquitination;protein K63-linked deubiquitination;response to ischemia","microtubule binding;polyubiquitin modification-dependent protein binding","BRISC complex;cytoplasm;cytosol;microtubule;spindle pole",{"$nulls":3},2,2,2,"8.2","8.2","8.2","46.9","0.0027845","2.2082",13027000,2,"0.294714","0.735298","6.62107","0.800663","sp|Q15018|F175B_HUMAN","sp|Q15018|F175B_HUMAN",1661,"Q15018","ABRX2_HUMAN","BRISC complex subunit Abraxas 2 {ECO:0000312|HGNC:HGNC:28975}",null,"ABRAXAS2"]
["14.769","14.9888","15.5413",1,{"$nulls":3},"biotin metabolic process;short-chain fatty acid catabolic process","ATP binding;biotin binding;biotin carboxylase activity;enzyme binding;metal ion binding;propionyl-CoA carboxylase activity","cytosol;mitochondrial matrix","Carbon metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,1,1,1,"1.9","1.9","1.9","80.058","0.0011001","2.6357",11685000,1,"0.337822","0.699225","6.60828","0.908795","sp|P05165|PCCA_HUMAN","sp|P05165|PCCA_HUMAN",515,"P05165","PCCA_HUMAN","Propionyl-CoA carboxylase alpha chain, mitochondrial","CCase subunit alpha","PCCA"]
["14.3299","13.0106","13.1244",1,{"$nulls":3},"muscle contraction;muscle organ development;neuromuscular junction development;positive regulation of cell-matrix adhesion;regulation of sodium ion transmembrane transporter activity;response to denervation involved in regulation of muscle adaptation","actin binding;actin filament binding;integrin binding;protein kinase binding;vinculin binding;zinc ion binding","cell junction;cortical actin cytoskeleton;cytoplasm;cytoskeleton;dystrophin-associated glycoprotein complex;extracellular exosome;filopodium;filopodium membrane;growth cone;membrane;neuromuscular junction;nucleoplasm;plasma membrane;postsynaptic membrane;protein complex;sarcolemma",{"$nulls":3},2,2,2,"0.7","0.7","0.7","394.46",0,"8.1887",16592000,5,"0.406965","0.611255","6.60808","1.08365","sp|P46939|UTRO_HUMAN","sp|P46939|UTRO_HUMAN",1040,"P46939","UTRO_HUMAN","Utrophin",null,"UTRN"]
["15.1168","15.6288","16.6398",1,{"$nulls":3},"5-phosphoribose 1-diphosphate biosynthetic process;AMP biosynthetic process;animal organ regeneration;nucleobase-containing compound metabolic process;nucleoside metabolic process","ADP binding;AMP binding;ATP binding;carbohydrate binding;GDP binding;identical protein binding;kinase activity;magnesium ion binding;protein homodimerization activity;ribose phosphate diphosphokinase activity","extracellular exosome;protein complex;ribose phosphate diphosphokinase complex","Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Pentose phosphate pathway;Purine metabolism",null,null,2,1,1,"10.1","4.7","4.7","34.769","0.0010757","2.4125",10093000,2,"0.309421","0.716496","6.55291","0.837532","sp|P11908|PRPS2_HUMAN;tr|A6NMS2|A6NMS2_HUMAN;tr|D3YTJ7|D3YTJ7_HUMAN","sp|P11908|PRPS2_HUMAN;tr|A6NMS2|A6NMS2_HUMAN;tr|D3YTJ7|D3YTJ7_HUMAN",637,"P11908","PRPS2_HUMAN","Ribose-phosphate pyrophosphokinase 2",null,"PRPS2"]
["13.1821","13.0042",1,"12.1476",{"$nulls":3},"actin filament capping;axon guidance;ER to Golgi vesicle-mediated transport;MAPK cascade","actin binding;actin filament binding;ankyrin binding;Ras guanyl-nucleotide exchange factor activity;structural constituent of cytoskeleton","actin cytoskeleton;cell surface;cytosol;Golgi apparatus;intrinsic component of the cytoplasmic side of the plasma membrane;protein complex;spectrin;spectrin-associated cytoskeleton",{"$nulls":3},3,2,2,"1.7","1.3","1.3","246.47",0,"3.6977",10676000,2,"0.440433","0.562674","6.51939","1.1695","sp|P11277|SPTB1_HUMAN","sp|P11277|SPTB1_HUMAN",626,"P11277","SPTB1_HUMAN","Spectrin beta chain, erythrocytic",null,"SPTB"]
["14.5066","15.2768","15.7638",1,{"$nulls":3},"cell volume homeostasis","potassium:chloride symporter activity","integral component of plasma membrane",{"$nulls":3},1,1,1,"2.1","2.1","2.1","119.13",0,"3.8131",13070000,4,"0.326617","0.705792","6.5098","0.88066","tr|A0A0G2JNW7|A0A0G2JNW7_HUMAN;sp|Q9Y666|S12A7_HUMAN","tr|A0A0G2JNW7|A0A0G2JNW7_HUMAN;sp|Q9Y666|S12A7_HUMAN",3038,"A0A0G2JNW7","A0A0G2JNW7_HUMAN",null,null,"SLC12A7"]
["14.6521","18.038","18.7631",1,{"$nulls":4},"metal ion binding;methyltransferase activity",{"$nulls":4},1,1,1,"2.6","2.6","2.6","47.34",0,"8.6239",21337000,4,"0.260529","0.761282","6.46347","0.714869","sp|Q6GMV2|SMYD5_HUMAN","sp|Q6GMV2|SMYD5_HUMAN",1867,"Q6GMV2","SMYD5_HUMAN","SET and MYND domain-containing protein 5",null,"SMYD5"]
["13.2593","14.3851","13.8744",1,{"$nulls":3},"endomembrane system organization;exocytosis;Golgi organization;negative regulation of actin filament polymerization;negative regulation of GTPase activity;neuron projection development;positive regulation of protein glycosylation in Golgi;positive regulation of protein kinase B signaling;positive regulation of wound healing;protein transport;regulation of ARF protein signal transduction;regulation of establishment of cell polarity","ARF guanyl-nucleotide exchange factor activity;guanyl-nucleotide exchange factor activity;myosin binding;protein kinase A regulatory subunit binding","cytosol;Golgi apparatus;Golgi membrane;nuclear matrix;nucleolus;nucleoplasm;perinuclear region of cytoplasm;small nuclear ribonucleoprotein complex;trans-Golgi network","Endocytosis",null,null,2,2,2,"1.4","1.4","1.4","208.76",0,"3.5087",14557000,4,"0.369317","0.658959","6.38499","0.988117","sp|Q9Y6D6|BIG1_HUMAN;tr|E5RIF2|E5RIF2_HUMAN","sp|Q9Y6D6|BIG1_HUMAN;tr|E5RIF2|E5RIF2_HUMAN",3046,"Q9Y6D6","BIG1_HUMAN","Brefeldin A-inhibited guanine nucleotide-exchange protein 1","refeldin A-inhibited GEP 1","ARFGEF1"]
["14.5609","14.8708","15.8017",1,{"$nulls":3},"actomyosin structure organization;apical constriction;axial mesoderm morphogenesis;cellular response to transforming growth factor beta stimulus;ectoderm development;embryonic foregut morphogenesis;endoderm development;epithelial to mesenchymal transition;in utero embryonic development;left/right axis specification;mesoderm migration involved in gastrulation;negative regulation of cell-cell adhesion;negative regulation of protein binding;neural plate morphogenesis;paraxial mesoderm development;positive regulation of epithelial cell migration;positive regulation of epithelial to mesenchymal transition;positive regulation of focal adhesion assembly;positive regulation of protein binding;posttranscriptional regulation of gene expression;regulation of establishment of protein localization;somite rostral/caudal axis specification;substrate-dependent cell migration, cell attachment to substrate;unidimensional cell growth","cytoskeletal protein binding;protein domain specific binding;structural constituent of cytoskeleton","cytoskeleton;cytosol;focal adhesion;plasma membrane;ruffle membrane",{"$nulls":3},1,1,1,"1.9","1.9","1.9","81.855","0.0010733","2.3954",12132000,3,"0.315627","0.714118","6.31499","0.853091","sp|Q9HCM4|E41L5_HUMAN","sp|Q9HCM4|E41L5_HUMAN",2646,"Q9HCM4","E41L5_HUMAN","Band 4.1-like protein 5",null,"EPB41L5"]
["13.7623","14.5718","14.7577",1,{"$nulls":3},"early endosome to late endosome transport;endocytic recycling;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;protein autophosphorylation;protein phosphorylation;receptor recycling;transferrin transport","ATP binding;myosin VI binding;protein phosphatase inhibitor activity;protein serine/threonine kinase activity","cytosol;early endosome;Golgi apparatus;growth cone;integral component of membrane;neuronal cell body;perinuclear region of cytoplasm;recycling endosome",{"$nulls":3},1,1,1,"0.9","0.9","0.9","164.9","0.0014104","2.3188",4859700,3,"0.339318","0.697782","6.28819","0.912556","sp|Q8IWU2|LMTK2_HUMAN","sp|Q8IWU2|LMTK2_HUMAN",2016,"Q8IWU2","LMTK2_HUMAN","Serine/threonine-protein kinase LMTK2",null,"LMTK2"]
["13.7587","14.1439",1,"14.4039",{"$nulls":3},"DNA-templated transcription, initiation;negative regulation of cell cycle;negative regulation of cell proliferation;regulation of DNA binding transcription factor activity;regulation of signal transduction by p53 class mediator;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","aryl hydrocarbon receptor binding;DNA binding;DNA binding transcription factor activity;protein heterodimerization activity","cytosol;MLL1 complex;nucleoplasm;nucleus;protein complex;transcription factor TFIID complex;transcription factor TFTC complex","Basal transcription factors",null,null,1,1,1,"1.8","1.8","1.8","72.668","0.0027682","2.1671",8141300,1,"0.347083","0.687665","6.24933","0.932077","sp|P49848|TAF6_HUMAN;tr|J3KR72|J3KR72_HUMAN","sp|P49848|TAF6_HUMAN;tr|J3KR72|J3KR72_HUMAN",1102,"P49848","TAF6_HUMAN","Transcription initiation factor TFIID subunit 6",null,"TAF6"]
["14.3241","14.0895",1,"14.9412",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;activation of JUN kinase activity;amyloid fibril formation;apoptotic process;apoptotic signaling pathway;cellular protein catabolic process;cellular response to growth factor stimulus;cellular response to tumor necrosis factor;death-inducing signaling complex assembly;extrinsic apoptotic signaling pathway;I-kappaB kinase/NF-kappaB signaling;MyD88-independent toll-like receptor signaling pathway;necroptotic process;necroptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of I-kappaB kinase/NF-kappaB signaling;peptidyl-serine autophosphorylation;positive regulation of apoptotic process;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of hydrogen peroxide-induced cell death;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interleukin-8 production;positive regulation of JNK cascade;positive regulation of macrophage differentiation;positive regulation of necroptotic process;positive regulation of necrotic cell death;positive regulation of NF-kappaB transcription factor activity;positive regulation of programmed cell death;positive regulation of protein phosphorylation;positive regulation of reactive oxygen species metabolic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor production;protein autophosphorylation;protein deubiquitination;protein heterooligomerization;protein homooligomerization;regulation of ATP:ADP antiporter activity;regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of necroptotic process;regulation of tumor necrosis factor-mediated signaling pathway;response to tumor necrosis factor;ripoptosome assembly;ripoptosome assembly involved in necroptotic process;T cell apoptotic process;toll-like receptor 3 signaling pathway;TRIF-dependent toll-like receptor signaling pathway;tumor necrosis factor-mediated signaling pathway;viral process","ATP binding;death domain binding;death receptor binding;identical protein binding;protein complex binding;protein kinase activity;protein serine/threonine kinase activity;signal transducer activity;ubiquitin protein ligase binding","cytosol;death-inducing signaling complex;endosome membrane;membrane raft;mitochondrion;receptor complex;ripoptosome","Apoptosis;Cytosolic DNA-sensing pathway;Epstein-Barr virus infection;Hepatitis C;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Necroptosis;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway",null,null,1,1,1,"2.5","2.5","2.5","75.93","0.0011078","2.7137",9424400,2,"0.332134","0.7035","6.23617","0.89451","sp|Q13546|RIPK1_HUMAN","sp|Q13546|RIPK1_HUMAN",1568,"Q13546","RIPK1_HUMAN","Receptor-interacting serine/threonine-protein kinase 1",null,"RIPK1"]
["13.3555","13.9454",1,"13.8403",{"$nulls":3},"lymphangiogenesis;negative regulation of cell proliferation;protein dephosphorylation;regulation of protein export from nucleus;regulation of transcription, DNA-templated;transcription, DNA-templated","protein tyrosine phosphatase activity;receptor tyrosine kinase binding;transcription cofactor activity","cytoplasm;cytoskeleton;nucleoplasm;nucleus",{"$nulls":3},1,1,1,2,2,2,"135.26","0.008178","1.7287",5439400,2,"0.361906","0.668365","6.23032","0.969411","sp|Q15678|PTN14_HUMAN","sp|Q15678|PTN14_HUMAN",1716,"Q15678","PTN14_HUMAN","Tyrosine-protein phosphatase non-receptor type 14",null,"PTPN14"]
["14.1594","16.0401","16.8064",1,{"$nulls":3},"lipid particle organization",null,"cell surface;endoplasmic reticulum membrane;Golgi apparatus;integral component of membrane;plasma membrane",{"$nulls":3},2,2,2,"2.3","2.3","2.3","98.555",0,"6.7415",41129000,5,"0.2859","0.745501","6.19654","0.778564","sp|Q9P2B2|FPRP_HUMAN","sp|Q9P2B2|FPRP_HUMAN",2784,"Q9P2B2","FPRP_HUMAN","Prostaglandin F2 receptor negative regulator",null,"PTGFRN"]
["14.7043","14.1276","15.5095",1,{"$nulls":3},"regulation of translational initiation;viral process","RNA binding;RNA cap binding;translation factor activity, RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 4F complex","RNA transport;Viral myocarditis",null,null,3,2,2,"2.3","1.7","1.7","176.65",0,"3.5135",18929000,4,"0.313831","0.714165","6.16117","0.848589","sp|O43432|IF4G3_HUMAN;tr|A0A0A0MSA7|A0A0A0MSA7_HUMAN","sp|O43432|IF4G3_HUMAN;tr|A0A0A0MSA7|A0A0A0MSA7_HUMAN",247,"O43432","IF4G3_HUMAN","Eukaryotic translation initiation factor 4 gamma 3","IF4G 3;IF-4G 3;IF-4-gamma 3","EIF4G3"]
["14.5597","14.0181","15.2777",1,{"$nulls":3},"maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA methylation","RNA binding;rRNA (guanine) methyltransferase activity;rRNA (uridine-2'-O-)-methyltransferase activity","nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},1,1,1,"2.2","2.2","2.2","96.557","0.00076746","2.9877",8551100,3,"0.318733","0.712004","6.1501","0.860881","sp|Q8IY81|SPB1_HUMAN","sp|Q8IY81|SPB1_HUMAN",2024,"Q8IY81","SPB1_HUMAN","pre-rRNA processing protein FTSJ3 {ECO:0000255|HAMAP-Rule:MF_03163}",null,"FTSJ3"]
["13.6124","14.0199",1,"14.4719",{"$nulls":3},"autophagy;Golgi to endosome transport;locomotory behavior;nervous system development;protein localization;protein transport;social behavior",null,"cytosol;dense core granule;intracellular",{"$nulls":3},1,1,1,"0.3","0.3","0.3","360.27",0,"4.7433",15531000,5,"0.335208","0.698215","6.08016","0.902229","sp|Q96RL7|VP13A_HUMAN","sp|Q96RL7|VP13A_HUMAN",2344,"Q96RL7","VP13A_HUMAN","Vacuolar protein sorting-associated protein 13A",null,"VPS13A"]
["13.1571","13.2319",1,"13.4196",{"$nulls":3},"peptide metabolic process;protein processing","metallocarboxypeptidase activity;serine-type carboxypeptidase activity;zinc ion binding","extracellular exosome;extracellular space;integral component of membrane;membrane;plasma membrane",{"$nulls":3},1,1,1,"2.5","2.5","2.5","152.93","0.0014001","2.2548",10841000,3,"0.359657","0.668986","5.98473","0.963741","sp|O75976|CBPD_HUMAN","sp|O75976|CBPD_HUMAN",382,"O75976","CBPD_HUMAN","Carboxypeptidase D",null,"CPD"]
["14.1847","14.9926","16.3974",1,{"$nulls":4},"ATP binding;protein serine/threonine kinase activity","cytosol;intercellular bridge",{"$nulls":3},1,1,1,"6.8","6.8","6.8","28.9","0.0004042","3.4429",6385500,1,"0.280096","0.750537","5.88995","0.764006","tr|K7ERP6|K7ERP6_HUMAN;sp|P17612|KAPCA_HUMAN","tr|K7ERP6|K7ERP6_HUMAN;sp|P17612|KAPCA_HUMAN",708,"K7ERP6","K7ERP6_HUMAN",null,null,"PRKACA"]
["14.411","14.4619",1,"16.1776",{"$nulls":3},"signal transduction","ATP binding;G-protein coupled receptor kinase activity",{"$nulls":4},1,1,1,"2.6","2.6","2.6","62.192","0.0014085","2.3125",7917500,4,"0.282706","0.745975","5.84762","0.770554","tr|F8W9W2|F8W9W2_HUMAN;sp|P43250|GRK6_HUMAN","tr|F8W9W2|F8W9W2_HUMAN;sp|P43250|GRK6_HUMAN",1007,"F8W9W2","F8W9W2_HUMAN","G protein-coupled receptor kinase {ECO:0000256|RuleBase:RU000308}",null,"GRK6"]
["13.784","13.4689","14.6439",1,{"$nulls":4},"beta-catenin binding","mediator complex",{"$nulls":3},1,1,1,"0.6","0.6","0.6","226.32",0,"4.4273",17894000,7,"0.314644","0.714241","5.80449","0.850628","tr|Q7Z3Z5|Q7Z3Z5_HUMAN;sp|Q93074|MED12_HUMAN","tr|Q7Z3Z5|Q7Z3Z5_HUMAN;sp|Q93074|MED12_HUMAN",2217,"Q7Z3Z5","Q7Z3Z5_HUMAN"]
["19.5308","19.2286","14.1274","14.8652",{"$nulls":3},"cholesterol biosynthetic process;isoprenoid biosynthetic process;ketone body biosynthetic process;regulation of lipid metabolic process","hydroxymethylglutaryl-CoA synthase activity","mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Butanoate metabolism;Metabolic pathways;PPAR signaling pathway;Synthesis and degradation of ketone bodies;Terpenoid backbone biosynthesis;Valine, leucine and isoleucine degradation",null,null,3,3,3,"8.1","8.1","8.1","56.635",0,"10.023",69947000,5,"2.18061","0.4224","4.88336","12.2504","sp|P54868|HMCS2_HUMAN","sp|P54868|HMCS2_HUMAN",1198,"P54868","HMCS2_HUMAN","Hydroxymethylglutaryl-CoA synthase, mitochondrial","MG-CoA synthase","HMGCS2"]
["12.7603","12.3453","16.1747",1,{"$nulls":3},"cell cycle;cellular response to DNA damage stimulus;cellular response to leukemia inhibitory factor;chromatin silencing at telomere;double-strand break repair via nonhomologous end joining;negative regulation of double-strand break repair via homologous recombination;negative regulation of transcription from RNA polymerase II promoter;positive regulation of double-strand break repair via nonhomologous end joining;positive regulation of histone H3-K9 methylation;positive regulation of isotype switching;stem cell population maintenance;telomere maintenance;telomere maintenance in response to DNA damage",null,"chromosome, telomeric region;condensed chromosome;cytoplasm;female pronucleus;male pronucleus;nuclear body;nuclear chromatin;nuclear membrane;nucleoplasm;nucleus;plasma membrane;site of double-strand break;spindle midzone","Signaling pathways regulating pluripotency of stem cells",null,null,4,4,4,"2.1","2.1","2.1","274.46",0,"10.243",35898000,7,"0.184776","0.835252","3.96545","0.522442","sp|Q5UIP0|RIF1_HUMAN;tr|H7C2B5|H7C2B5_HUMAN;tr|H7BZN3|H7BZN3_HUMAN","sp|Q5UIP0|RIF1_HUMAN",1841,"Q5UIP0","RIF1_HUMAN","Telomere-associated protein RIF1 {ECO:0000305}",null,"RIF1"]
["20.1635","19.7483","18.5828","14.0179",{"$nulls":3},"protein folding",null,"cytosol;intracellular membrane-bounded organelle;prefoldin complex",{"$nulls":3},3,3,3,"22.9","22.9","22.9","22.254",0,"8.2592",133920000,6,"0.59901","0.437724","3.65557","1.59499","tr|B4DWR3|B4DWR3_HUMAN;sp|P61758|PFD3_HUMAN","tr|B4DWR3|B4DWR3_HUMAN;sp|P61758|PFD3_HUMAN",1278,"B4DWR3","B4DWR3_HUMAN","Prefoldin subunit 3 {ECO:0000256|PIRNR:PIRNR016396}",null,"VBP1"]
["20.5294","20.4293","17.1926","17.3741",{"$nulls":3},"beta-catenin destruction complex assembly;beta-catenin destruction complex disassembly;cell cycle;cell division;cell morphogenesis;cell surface receptor signaling pathway;Golgi organization;intermediate filament cytoskeleton organization;negative regulation of canonical Wnt signaling pathway;peptidyl-serine phosphorylation;phagocytosis;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein phosphorylation;regulation of cell shape;regulation of GTP binding;signal transduction;Wnt signaling pathway","ATP binding;kinase activity;protein kinase activity;protein serine/threonine kinase activity","beta-catenin destruction complex;centrosome;ciliary basal body;cilium;condensed chromosome kinetochore;cytosol;intracellular ribonucleoprotein complex;membrane;nuclear speck","Breast cancer;Gastric cancer;Hedgehog signaling pathway;Hepatocellular carcinoma;Human papillomavirus infection;Wnt signaling pathway",null,null,2,2,2,"9.8","9.8","9.8","38.914",0,"23.34",146750000,10,"2.979","0.514939","3.19601","30.8432","sp|P48729|KC1A_HUMAN;tr|U3KQ83|U3KQ83_HUMAN;tr|U3KPX3|U3KPX3_HUMAN;tr|H0Y9X2|H0Y9X2_HUMAN;tr|U3KQK7|U3KQK7_HUMAN;tr|D6REM4|D6REM4_HUMAN;tr|E7ETM0|E7ETM0_HUMAN;sp|Q8N752|KC1AL_HUMAN","sp|P48729|KC1A_HUMAN;tr|U3KQ83|U3KQ83_HUMAN;tr|U3KPX3|U3KPX3_HUMAN;tr|H0Y9X2|H0Y9X2_HUMAN;tr|U3KQK7|U3KQK7_HUMAN;tr|D6REM4|D6REM4_HUMAN;tr|E7ETM0|E7ETM0_HUMAN;sp|Q8N752|KC1AL_HUMAN",1060,"P48729","KC1A_HUMAN","Casein kinase I isoform alpha","KI-alpha","CSNK1A1"]
["18.7469","19.442","17.0667","15.2114",{"$nulls":4},"DNA binding;protein heterodimerization activity","nucleosome;nucleus",{"$nulls":3},3,1,1,"36.9","23.8","23.8","13.163",0,"6.0504",9431400,2,"1.01602","0.294221","2.9554","2.98348","tr|C9J0D1|C9J0D1_HUMAN;sp|Q71UI9|H2AV_HUMAN;sp|P0C0S5|H2AZ_HUMAN","tr|C9J0D1|C9J0D1_HUMAN;sp|Q71UI9|H2AV_HUMAN;sp|P0C0S5|H2AZ_HUMAN",599,"C9J0D1","C9J0D1_HUMAN","Histone H2A {ECO:0000256|RuleBase:RU003767}",null,"H2AFV"]
["16.4785","17.1266","14.7297","13.0832",{"$nulls":4},"actin filament binding;metal ion binding","actin cytoskeleton",{"$nulls":3},4,4,4,"21.7","21.7","21.7","47.401",0,"10.837",33428000,10,"1.08613","0.308121","2.89608","3.27338","tr|H0Y704|H0Y704_HUMAN;tr|H7BZT5|H7BZT5_HUMAN;sp|O15231|ZN185_HUMAN","tr|H0Y704|H0Y704_HUMAN;tr|H7BZT5|H7BZT5_HUMAN;sp|O15231|ZN185_HUMAN",206,"H0Y704","H0Y704_HUMAN",null,null,"ZNF185"]
["19.4558","19.4575","17.3621","16.5035",{"$nulls":3},"cell division;cell proliferation;DNA repair;mitotic sister chromatid cohesion;negative regulation of cell proliferation;regulation of cell proliferation;sister chromatid cohesion","ATP binding;DNA binding","chromatin;chromosome;chromosome, centromeric region;cytosol;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"5.6","5.6","5.6","164.67",0,"14.074",165070000,13,"1.55694","0.332226","2.5238","5.87874","sp|Q9NTI5|PDS5B_HUMAN;tr|A9IYQ1|A9IYQ1_HUMAN","sp|Q9NTI5|PDS5B_HUMAN",2697,"Q9NTI5","PDS5B_HUMAN","Sister chromatid cohesion protein PDS5 homolog B",null,"PDS5B"]
["18.9369","18.7966","18.4034","14.4682",{"$nulls":4},"NADPH-adrenodoxin reductase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},2,2,2,"5.2","5.2","5.2","48.027",0,"5.3639",71722000,7,"0.465575","0.538074","2.43098","1.23472","tr|A0A0A0MTN9|A0A0A0MTN9_HUMAN;tr|J3QQX3|J3QQX3_HUMAN;tr|A0A0C4DFN8|A0A0C4DFN8_HUMAN;sp|P22570|ADRO_HUMAN;tr|A0A0C4DGN7|A0A0C4DGN7_HUMAN;tr|A0A0A0MSZ4|A0A0A0MSZ4_HUMAN;tr|A0A0A0MT64|A0A0A0MT64_HUMAN;tr|J3QKZ8|J3QKZ8_HUMAN;tr|A0A0A0MTR6|A0A0A0MTR6_HUMAN","tr|A0A0A0MTN9|A0A0A0MTN9_HUMAN;tr|J3QQX3|J3QQX3_HUMAN;tr|A0A0C4DFN8|A0A0C4DFN8_HUMAN;sp|P22570|ADRO_HUMAN;tr|A0A0C4DGN7|A0A0C4DGN7_HUMAN;tr|A0A0A0MSZ4|A0A0A0MSZ4_HUMAN;tr|A0A0A0MT64|A0A0A0MT64_HUMAN;tr|J3QKZ8|J3QKZ8_HUMAN;tr|A0A0A0MTR6|A0A0A0MTR6_HUMAN",766,"A0A0A0MTN9","A0A0A0MTN9_HUMAN","NADPH:adrenodoxin oxidoreductase, mitochondrial {ECO:0000256|PIRNR:PIRNR000362}",null,"FDXR"]
["17.7115","17.6769","16.191","14.4624",{"$nulls":9},2,2,2,"11.4","11.4","11.4","29.956",0,"4.8205",13035000,3,"0.952793","0.296761","2.36747","2.73853","tr|H0Y6A0|H0Y6A0_HUMAN;sp|Q9NP61|ARFG3_HUMAN","tr|H0Y6A0|H0Y6A0_HUMAN;sp|Q9NP61|ARFG3_HUMAN",3101,"H0Y6A0","H0Y6A0_HUMAN",null,null,"ARFGAP3"]
["22.331","21.9796","17.9094","22.1969",{"$nulls":3},"cell redox homeostasis","isomerase activity","cell",{"$nulls":3},6,1,1,"41.5","11.4","11.4","13.519",0,"3.5606",404350000,8,"0.365038","0.663779","2.10219","0.977314","tr|H7BZJ3|H7BZJ3_HUMAN","tr|H7BZJ3|H7BZJ3_HUMAN",3106,"H7BZJ3","H7BZJ3_HUMAN",null,null,"PDIA3"]
["25.6961","25.7212","23.801","23.526",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular protein metabolic process;CENP-A containing nucleosome assembly;chromatin silencing at rDNA;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;DNA-templated transcription, initiation;double-strand break repair via nonhomologous end joining;negative regulation of gene expression, epigenetic;negative regulation of megakaryocyte differentiation;nucleosome assembly;positive regulation of gene expression, epigenetic;protein heterotetramerization;regulation of gene silencing by miRNA;regulation of hematopoietic stem cell differentiation;regulation of megakaryocyte differentiation;telomere capping;telomere organization","DNA binding;histone binding;protein domain specific binding;protein heterodimerization activity;RNA binding","extracellular exosome;extracellular matrix;extracellular region;membrane;nuclear chromosome;nuclear chromosome, telomeric region;nuclear nucleosome;nucleoplasm;nucleosome;nucleus;protein complex","Alcoholism;Systemic lupus erythematosus;Viral carcinogenesis",null,null,5,5,5,"46.6","46.6","46.6","11.367",0,"12.459",987460000,14,"2.34407","0.462914","2.04515","14.81","sp|P62805|H4_HUMAN","sp|P62805|H4_HUMAN",1314,"P62805","H4_HUMAN","Histone H4",null,"HIST1H4A;HIST1H4B;HIST1H4C;HIST1H4D;HIST1H4E;HIST1H4F;HIST1H4H;HIST1H4I;HIST1H4J;HIST1H4K;HIST1H4L;HIST2H4A;HIST2H4B;HIST4H4"]
["20.1463","20.4158","17.4287","19.1708",{"$nulls":9},1,1,1,"5.7","5.7","5.7","23.506","0.0011177","2.7704",73773000,8,"0.813679","0.323271","1.98127","2.2479","tr|V9GZ55|V9GZ55_HUMAN;tr|K7ENR6|K7ENR6_HUMAN;sp|Q969U7|PSMG2_HUMAN","tr|V9GZ55|V9GZ55_HUMAN;tr|K7ENR6|K7ENR6_HUMAN;sp|Q969U7|PSMG2_HUMAN",2223,"V9GZ55","V9GZ55_HUMAN",null,null,"PSMG2"]
["25.2501","25.2097","23.4561","23.2808",{"$nulls":4},"DNA binding;protein heterodimerization activity","nucleosome;nucleus",{"$nulls":3},3,3,3,25,25,25,"10.334",0,"17.788",596510000,14,"2.63301","0.574933","1.86146","20.6894","tr|K7EMV3|K7EMV3_HUMAN;tr|B4DEB1|B4DEB1_HUMAN;tr|K7EK07|K7EK07_HUMAN;sp|Q71DI3|H32_HUMAN;sp|Q16695|H31T_HUMAN;sp|P84243|H33_HUMAN;sp|P68431|H31_HUMAN;tr|K7ES00|K7ES00_HUMAN;tr|K7EP01|K7EP01_HUMAN;sp|Q6NXT2|H3C_HUMAN;tr|Q5TEC6|Q5TEC6_HUMAN","tr|K7EMV3|K7EMV3_HUMAN;tr|B4DEB1|B4DEB1_HUMAN;tr|K7EK07|K7EK07_HUMAN;sp|Q71DI3|H32_HUMAN;sp|Q16695|H31T_HUMAN;sp|P84243|H33_HUMAN;sp|P68431|H31_HUMAN;tr|K7ES00|K7ES00_HUMAN;tr|K7EP01|K7EP01_HUMAN;sp|Q6NXT2|H3C_HUMAN;tr|Q5TEC6|Q5TEC6_HUMAN",1362,"K7EMV3","K7EMV3_HUMAN","Histone H3 {ECO:0000256|RuleBase:RU004471}",null,"H3F3B"]
["17.4972","18.8216","14.6906","17.972",{"$nulls":3},"positive regulation of phagocytosis;protein transport;retrograde vesicle-mediated transport, Golgi to ER","carbohydrate binding;heat shock protein binding;mannose binding;metal ion binding","cell surface;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;extracellular space;Golgi apparatus;Golgi membrane;integral component of plasma membrane","Protein processing in endoplasmic reticulum",null,null,4,4,4,"19.9","19.9","19.9","40.228",0,"31.653",62716000,13,"0.387159","0.632808","1.82815","1.03327","sp|Q12907|LMAN2_HUMAN;tr|D6RBV2|D6RBV2_HUMAN;tr|D6RIU4|D6RIU4_HUMAN;tr|D6RDX1|D6RDX1_HUMAN;tr|D6RBH1|D6RBH1_HUMAN","sp|Q12907|LMAN2_HUMAN;tr|D6RBV2|D6RBV2_HUMAN;tr|D6RIU4|D6RIU4_HUMAN;tr|D6RDX1|D6RDX1_HUMAN",1506,"Q12907","LMAN2_HUMAN","Vesicular integral-membrane protein VIP36",null,"LMAN2"]
["17.0651","16.6618","15.4152","14.673",{"$nulls":3},"chromatin silencing;covalent chromatin modification;dosage compensation;establishment of protein localization to chromatin;negative regulation of cell cycle G2/M phase transition;negative regulation of gene expression, epigenetic;negative regulation of histone H3-K27 methylation;negative regulation of histone H3-K4 methylation;negative regulation of histone phosphorylation;negative regulation of protein localization to chromosome, telomeric region;negative regulation of protein serine/threonine kinase activity;negative regulation of response to oxidative stress;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;nucleosome assembly;positive regulation of gene expression, epigenetic;positive regulation of keratinocyte differentiation;positive regulation of maintenance of mitotic sister chromatid cohesion;positive regulation of response to oxidative stress;regulation of gene expression, epigenetic;regulation of lipid metabolic process;regulation of response to oxidative stress","chromatin DNA binding;core promoter sequence-specific DNA binding;DNA binding;double-stranded methylated DNA binding;enzyme binding;nucleosomal DNA binding;protein heterodimerization activity;protein kinase binding;protein serine/threonine kinase inhibitor activity;rDNA binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription regulatory region DNA binding","Barr body;condensed chromosome;extracellular exosome;nuclear chromatin;nuclear chromosome;nuclear chromosome, telomeric region;nucleolus;nucleosome;nucleus;pericentric heterochromatin;sex chromatin","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,1,1,1,"5.9","5.9","5.9","39.617","0.0011161","2.7636",6663500,2,"1.3019","0.33431","1.81932","4.30731","sp|O75367|H2AY_HUMAN","sp|O75367|H2AY_HUMAN",334,"O75367","H2AY_HUMAN","Core histone macro-H2A.1","H2A1;istone macroH2A1","H2AFY"]
["18.1787","20.3046","17.727","17.153",{"$nulls":3},"transmembrane transport",null,"integral component of membrane",{"$nulls":3},2,2,2,"23.2","23.2","23.2","18.898",0,"7.3287",30538000,9,"0.61366","0.425497","1.80164","1.63633","tr|K4DIB8|K4DIB8_HUMAN;tr|K4DIA8|K4DIA8_HUMAN;tr|E9PS95|E9PS95_HUMAN;tr|A0A0D9SEI9|A0A0D9SEI9_HUMAN;tr|A0A0D9SFE1|A0A0D9SFE1_HUMAN;tr|E9PJH7|E9PJH7_HUMAN;sp|Q9H936|GHC1_HUMAN;tr|K4DIB6|K4DIB6_HUMAN;tr|K4DIB3|K4DIB3_HUMAN;sp|Q9H1K4|GHC2_HUMAN","tr|K4DIB8|K4DIB8_HUMAN;tr|K4DIA8|K4DIA8_HUMAN;tr|E9PS95|E9PS95_HUMAN;tr|A0A0D9SEI9|A0A0D9SEI9_HUMAN;tr|A0A0D9SFE1|A0A0D9SFE1_HUMAN;tr|E9PJH7|E9PJH7_HUMAN;sp|Q9H936|GHC1_HUMAN;tr|K4DIB6|K4DIB6_HUMAN;tr|K4DIB3|K4DIB3_HUMAN;sp|Q9H1K4|GHC2_HUMAN",2618,"K4DIB8","K4DIB8_HUMAN",null,null,"SLC25A22"]
["22.4423","22.5908","20.6528","20.8538",{"$nulls":4},"nucleosomal DNA binding","chromatin;nucleus",{"$nulls":3},3,3,3,"37.8","37.8","37.8","9.5355",0,"28.506",123230000,9,"2.30247","0.436","1.76328","14.1125","tr|A6NL93|A6NL93_HUMAN;sp|P05114|HMGN1_HUMAN;tr|A6NEL0|A6NEL0_HUMAN","tr|A6NL93|A6NL93_HUMAN;sp|P05114|HMGN1_HUMAN;tr|A6NEL0|A6NEL0_HUMAN",511,"A6NL93","A6NL93_HUMAN",null,null,"HMGN1"]
["17.7799","18.8436","18.2273","14.8967",{"$nulls":3},"muscle contraction","actin binding;calmodulin binding;PDZ domain binding;structural molecule activity","cytoplasm;cytoskeleton;dystrophin-associated glycoprotein complex;focal adhesion;protein complex;sarcolemma;synapse",{"$nulls":3},3,3,3,"9.7","9.7","9.7","58.06",0,"7.1246",82644000,9,"0.374379","0.650607","1.74973","1.00091","sp|Q13884|SNTB1_HUMAN","sp|Q13884|SNTB1_HUMAN",1589,"Q13884","SNTB1_HUMAN","Beta-1-syntrophin",null,"SNTB1"]
["18.3603","16.9537","15.771","16.0611",{"$nulls":3},"endocytosis;phosphatidylinositol biosynthetic process;regulation of endocytosis","lipid binding;metal ion binding;protein transporter activity;SH2 domain binding;SH3 domain binding","cytosol;early endosome membrane;endosome;intracellular membrane-bounded organelle;nuclear speck","Endocytosis",null,null,2,2,2,"3.8","3.8","3.8","79.817",0,"7.0911",53346000,5,"0.865752","0.302462","1.74095","2.42435","sp|Q96T51|RUFY1_HUMAN;tr|H0YAC8|H0YAC8_HUMAN","sp|Q96T51|RUFY1_HUMAN;tr|H0YAC8|H0YAC8_HUMAN",2361,"Q96T51","RUFY1_HUMAN","RUN and FYVE domain-containing protein 1",null,"RUFY1"]
["24.6759","24.5598","23.0334","22.8579",{"$nulls":3},"antibacterial humoral response;antimicrobial humoral immune response mediated by antimicrobial peptide;defense response to Gram-positive bacterium;innate immune response in mucosa","DNA binding;protein heterodimerization activity","cytosol;extracellular space;nucleoplasm;nucleosome",{"$nulls":3},3,3,3,"26.2","26.2","26.2","13.906",0,"28.377",597920000,14,"2.4052","0.481039","1.67218","15.8971","tr|B2R4S9|B2R4S9_HUMAN;sp|Q99880|H2B1L_HUMAN;sp|Q99879|H2B1M_HUMAN;sp|Q99877|H2B1N_HUMAN;sp|Q93079|H2B1H_HUMAN;sp|Q5QNW6|H2B2F_HUMAN;sp|P62807|H2B1C_HUMAN;sp|P58876|H2B1D_HUMAN;sp|P57053|H2BFS_HUMAN;sp|O60814|H2B1K_HUMAN;tr|U3KQK0|U3KQK0_HUMAN;sp|Q8N257|H2B3B_HUMAN;sp|Q16778|H2B2E_HUMAN;sp|P33778|H2B1B_HUMAN;sp|P23527|H2B1O_HUMAN;sp|P06899|H2B1J_HUMAN;sp|Q96A08|H2B1A_HUMAN","tr|B2R4S9|B2R4S9_HUMAN;sp|Q99880|H2B1L_HUMAN;sp|Q99879|H2B1M_HUMAN;sp|Q99877|H2B1N_HUMAN;sp|Q93079|H2B1H_HUMAN;sp|Q5QNW6|H2B2F_HUMAN;sp|P62807|H2B1C_HUMAN;sp|P58876|H2B1D_HUMAN;sp|P57053|H2BFS_HUMAN;sp|O60814|H2B1K_HUMAN;tr|U3KQK0|U3KQK0_HUMAN;sp|Q8N257|H2B3B_HUMAN;sp|Q16778|H2B2E_HUMAN;sp|P33778|H2B1B_HUMAN;sp|P23527|H2B1O_HUMAN;sp|P06899|H2B1J_HUMAN",306,"B2R4S9","B2R4S9_HUMAN","Histone H2B {ECO:0000256|RuleBase:RU000451}",null,"HIST1H2BC"]
["17.6798","17.069","16.3098","15.1083",{"$nulls":3},"ectodermal cell differentiation;embryonic ectodermal digestive tract development;endocytic recycling;Golgi to vacuole transport;lysosomal transport;protein transport;retrograde transport, endosome to Golgi","Rab GTPase binding;syntaxin binding","cytosol;EARP complex;endosome membrane;GARP complex;Golgi apparatus;membrane;perinuclear region of cytoplasm;recycling endosome;trans-Golgi network membrane",{"$nulls":3},2,2,2,"3.3","3.3","3.3","82.22","0.0010745","2.4105",50308000,3,"0.879132","0.302115","1.66535","2.47103","sp|Q8N1B4|VPS52_HUMAN","sp|Q8N1B4|VPS52_HUMAN",2035,"Q8N1B4","VPS52_HUMAN","Vacuolar protein sorting-associated protein 52 homolog",null,"VPS52"]
["16.6712","16.8746","16.5615","13.7073",{"$nulls":3},"cornification;epithelial cell morphogenesis involved in placental branching;keratinocyte differentiation;neural tube closure;proteolysis","endopeptidase activity;serine-type endopeptidase activity;serine-type peptidase activity","basolateral plasma membrane;extracellular exosome;extrinsic component of plasma membrane;integral component of plasma membrane;plasma membrane","MicroRNAs in cancer",null,null,2,2,2,3,3,3,"94.769","0.0053709","1.9039",11711000,3,"0.431023","0.579134","1.63855","1.14526","sp|Q9Y5Y6|ST14_HUMAN","sp|Q9Y5Y6|ST14_HUMAN",3034,"Q9Y5Y6","ST14_HUMAN","Suppressor of tumorigenicity 14 protein",null,"ST14"]
["18.1747","18.9933","16.747","17.2282",{"$nulls":3},"oocyte maturation;spindle assembly involved in female meiosis","GTP binding;GTPase activity;structural constituent of cytoskeleton","cytoplasm;extracellular exosome;meiotic spindle;microtubule;microtubule cytoskeleton","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,8,1,1,"22.5","7.2","7.2","49.775",0,"73.625",40720000,9,"1.10674","0.309153","1.59642","3.36253","sp|Q3ZCM7|TBB8_HUMAN;tr|A0A075B736|A0A075B736_HUMAN;tr|Q5SQY0|Q5SQY0_HUMAN","sp|Q3ZCM7|TBB8_HUMAN;tr|A0A075B736|A0A075B736_HUMAN;tr|Q5SQY0|Q5SQY0_HUMAN",1783,"Q3ZCM7","TBB8_HUMAN","Tubulin beta-8 chain {ECO:0000305}",null,"TUBB8"]
["24.1524","24.169","24.3079","20.8587",{"$nulls":3},"epithelial to mesenchymal transition;positive regulation of I-kappaB kinase/NF-kappaB signaling","actin binding;calcium ion binding;calcium-dependent protein binding;identical protein binding;RAGE receptor binding;RNA binding;transition metal ion binding","extracellular exosome;extracellular region;extracellular space;neuron projection;nucleus;perinuclear region of cytoplasm",{"$nulls":3},3,3,3,"27.7","27.7","27.7","11.728",0,"7.8519",936140000,21,"0.340133","0.695906","1.57735","0.914604","sp|P26447|S10A4_HUMAN","sp|P26447|S10A4_HUMAN",812,"P26447","S10A4_HUMAN","Protein S100-A4",null,"S100A4"]
["24.3779","19.4916","20.9802","19.7573",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;ribosomal large subunit assembly;translation","RNA binding;rRNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome;mitochondrion","Ribosome",null,null,5,5,5,"31.2","31.2","31.2","20.683",0,"92.396",856170000,24,"0.223656","0.798816","1.56599","0.621798","sp|Q9Y3B7|RM11_HUMAN;tr|H0YCD5|H0YCD5_HUMAN;tr|E9PQB6|E9PQB6_HUMAN","sp|Q9Y3B7|RM11_HUMAN",2980,"Q9Y3B7","RM11_HUMAN","39S ribosomal protein L11, mitochondrial","11mt;RP-L11","MRPL11"]
["17.9248","17.9484","17.9072","14.8747",{"$nulls":5},"intracellular membrane-bounded organelle;nucleus",{"$nulls":3},4,4,4,"7.1","7.1","7.1","96.669",0,"15.576",65582000,14,"0.381663","0.639765","1.54565","1.01934","tr|E9PFH4|E9PFH4_HUMAN;sp|Q9Y5L0|TNPO3_HUMAN;tr|C9J7E5|C9J7E5_HUMAN","tr|E9PFH4|E9PFH4_HUMAN;sp|Q9Y5L0|TNPO3_HUMAN;tr|C9J7E5|C9J7E5_HUMAN",3020,"E9PFH4","E9PFH4_HUMAN",null,null,"TNPO3"]
["19.1118","19.0393","16.0778","18.9905",{"$nulls":3},"cell differentiation","RNA binding","cytoplasm;extracellular exosome;membrane;nucleus",{"$nulls":3},4,4,4,"2.3","2.3","2.3","228.86",0,"9.7351",258240000,11,"0.396912","0.623036","1.5414","1.05804","sp|P48634|PRC2A_HUMAN","sp|P48634|PRC2A_HUMAN",1056,"P48634","PRC2A_HUMAN","Protein PRRC2A",null,"PRRC2A"]
["20.4992","20.4188","18.8958","19.0106",{"$nulls":3},"mRNA splicing, via spliceosome;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA processing","pre-mRNA intronic binding;RNA binding;transcription regulatory region DNA binding","cytoplasm;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus;ribonucleoprotein granule",{"$nulls":3},3,3,2,"11.9","11.9","10.4","64.132",0,"23.534",109560000,13,"2.66592","0.586105","1.50585","21.4911","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN",676,"P14866","HNRPL_HUMAN","Heterogeneous nuclear ribonucleoprotein L","nRNP L","HNRNPL"]
[1,"18.0628","15.0789",1,{"$nulls":3},"glycogen biosynthetic process","1,4-alpha-glucan branching enzyme activity;cation binding;hydrolase activity, hydrolyzing O-glycosyl compounds",{"$nulls":4},1,1,1,"1.7","1.7","1.7","75.959","0.0031067","2.1333",9560800,2,"0.0433265","0.954022","1.49193","0.134886","tr|E9PGM4|E9PGM4_HUMAN;sp|Q04446|GLGB_HUMAN","tr|E9PGM4|E9PGM4_HUMAN;sp|Q04446|GLGB_HUMAN",1442,"E9PGM4","E9PGM4_HUMAN",null,null,"GBE1"]
["21.5772","19.9808","19.4387","19.1597",{"$nulls":3},"cell differentiation;cell proliferation;regulation of myeloid cell differentiation;transcription, DNA-templated","mRNA binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;single-stranded DNA binding;SMAD binding;transcription factor binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","DNA replication factor A complex;nucleus",{"$nulls":3},4,4,4,"33.7","33.7","33.7","33.24",0,"40.919",122670000,12,"0.679117","0.379347","1.47981","1.82621","sp|Q96QR8|PURB_HUMAN","sp|Q96QR8|PURB_HUMAN",2340,"Q96QR8","PURB_HUMAN","Transcriptional activator protein Pur-beta",null,"PURB"]
["22.4484","22.8131","21.1649","21.1426",{"$nulls":9},1,1,1,"38.7","38.7","38.7","6.1895",0,"43.17",55133000,5,"1.82513","0.383886","1.47697","8.08447","tr|C9JLG5|C9JLG5_HUMAN;tr|C9JA65|C9JA65_HUMAN;sp|O00458|IFRD1_HUMAN","tr|C9JLG5|C9JLG5_HUMAN;tr|C9JA65|C9JA65_HUMAN;sp|O00458|IFRD1_HUMAN",144,"C9JLG5","C9JLG5_HUMAN",null,null,"IFRD1"]
["15.4672","16.741","14.9897","14.2734",{"$nulls":3},"acetate biosynthetic process;acetyl-CoA biosynthetic process;acetyl-CoA biosynthetic process from acetate;ethanol oxidation;propionate biosynthetic process","acetate-CoA ligase activity;AMP binding;ATP binding","mitochondrial matrix","Carbon metabolism;Glycolysis / Gluconeogenesis;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism",null,null,2,2,2,"3.6","3.6","3.6","74.856","0.0010627","2.3525",23877000,6,"0.741265","0.342197","1.47255","2.01527","sp|Q9NUB1|ACS2L_HUMAN","sp|Q9NUB1|ACS2L_HUMAN",2703,"Q9NUB1","ACS2L_HUMAN","Acetyl-coenzyme A synthetase 2-like, mitochondrial",null,"ACSS1"]
["19.7371","19.935","17.8392","18.9266",{"$nulls":4},"RNA binding","intracellular ribonucleoprotein complex;viral nucleocapsid",{"$nulls":3},4,4,4,"25.5","25.5","25.5","31.948",0,"3.716",72736000,9,"0.92337","0.293202","1.45318","2.62948","tr|B2R5W2|B2R5W2_HUMAN;tr|G3V4C1|G3V4C1_HUMAN;tr|G3V2Q1|G3V2Q1_HUMAN;sp|P07910|HNRPC_HUMAN;tr|G3V555|G3V555_HUMAN;tr|G3V575|G3V575_HUMAN;tr|G3V576|G3V576_HUMAN;tr|G3V4W0|G3V4W0_HUMAN;tr|B4DY08|B4DY08_HUMAN;tr|G3V5X6|G3V5X6_HUMAN;tr|G3V3K6|G3V3K6_HUMAN;tr|G3V251|G3V251_HUMAN;tr|B4DSU6|B4DSU6_HUMAN;tr|G3V5V7|G3V5V7_HUMAN;tr|G3V2D6|G3V2D6_HUMAN;tr|G3V4M8|G3V4M8_HUMAN","tr|B2R5W2|B2R5W2_HUMAN;tr|G3V4C1|G3V4C1_HUMAN;tr|G3V2Q1|G3V2Q1_HUMAN;sp|P07910|HNRPC_HUMAN;tr|G3V555|G3V555_HUMAN;tr|G3V575|G3V575_HUMAN;tr|G3V576|G3V576_HUMAN;tr|G3V4W0|G3V4W0_HUMAN;tr|B4DY08|B4DY08_HUMAN;tr|G3V5X6|G3V5X6_HUMAN;tr|G3V3K6|G3V3K6_HUMAN;tr|G3V251|G3V251_HUMAN;tr|B4DSU6|B4DSU6_HUMAN;tr|G3V5V7|G3V5V7_HUMAN;tr|G3V2D6|G3V2D6_HUMAN",552,"B2R5W2","B2R5W2_HUMAN",null,null,"HNRNPC"]
["20.8368","21.3611","21.5041","17.8403",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,3,3,3,"14.4","14.4","14.4","33.3","0.0011244","2.7984",327580000,9,"0.28287","0.745847","1.42674","0.770966","sp|Q5T653|RM02_HUMAN;tr|C9IY40|C9IY40_HUMAN","sp|Q5T653|RM02_HUMAN;tr|C9IY40|C9IY40_HUMAN",1834,"Q5T653","RM02_HUMAN","39S ribosomal protein L2, mitochondrial","2mt;RP-L2","MRPL2"]
["16.5018","16.3243","14.6997","15.352",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;antigen processing and presentation, exogenous lipid antigen via MHC class Ib;endosome to melanosome transport;eye pigment biosynthetic process;intracellular protein transport;melanosome organization;neurotransmitter receptor transport, postsynaptic endosome to lysosome;positive regulation of NK T cell differentiation;protein localization to membrane;regulation of sequestering of zinc ion;synaptic vesicle budding from endosome;synaptic vesicle membrane organization","transporter activity","AP-3 adaptor complex;axon cytoplasm;endosome membrane;Golgi apparatus;Golgi membrane;lysosomal membrane;membrane;plasma membrane;presynaptic endosome;terminal bouton","Lysosome",null,null,1,1,1,"1.1","1.1","1.1","130.16",0,"15.832",26696000,5,"1.26304","0.325684","1.38718","4.10353","sp|O14617|AP3D1_HUMAN","sp|O14617|AP3D1_HUMAN",163,"O14617","AP3D1_HUMAN","AP-3 complex subunit delta-1",null,"AP3D1"]
["20.5497","20.7455","20.7292","17.8083",{"$nulls":3},"negative regulation of actin filament polymerization","actin binding","intracellular",{"$nulls":3},4,4,4,"24.8","24.8","24.8","28.882",0,"16.625",239980000,14,"0.351022","0.685761","1.37886","0.941989","tr|D6RG15|D6RG15_HUMAN;sp|Q6IBS0|TWF2_HUMAN;tr|H0Y858|H0Y858_HUMAN","tr|D6RG15|D6RG15_HUMAN;sp|Q6IBS0|TWF2_HUMAN;tr|H0Y858|H0Y858_HUMAN",1869,"D6RG15","D6RG15_HUMAN",null,null,"TWF2"]
["22.3918","21.668","19.4091","21.8983",{"$nulls":3},"RNA processing",{"$nulls":5},2,2,2,44,44,44,"8.3926",0,"11.563",71784000,7,"0.398387","0.622975","1.37624","1.0618","tr|J3QLI9|J3QLI9_HUMAN;sp|P62314|SMD1_HUMAN","tr|J3QLI9|J3QLI9_HUMAN;sp|P62314|SMD1_HUMAN",1304,"J3QLI9","J3QLI9_HUMAN",null,null,"SNRPD1"]
["18.8315","18.6777","18.375","16.443",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"15.8","15.8","15.8","15.864",0,"5.7203",10700000,5,"0.523756","0.502922","1.34562","1.38856","tr|C9JJV6|C9JJV6_HUMAN;tr|C9JZL8|C9JZL8_HUMAN;tr|C9J5M0|C9J5M0_HUMAN;tr|C9JC07|C9JC07_HUMAN;sp|Q96S97|MYADM_HUMAN","tr|C9JJV6|C9JJV6_HUMAN;tr|C9JZL8|C9JZL8_HUMAN;tr|C9J5M0|C9J5M0_HUMAN;tr|C9JC07|C9JC07_HUMAN;sp|Q96S97|MYADM_HUMAN",2354,"C9JJV6","C9JJV6_HUMAN",null,null,"MYADM"]
["16.742","16.554","16.0597","14.5899",{"$nulls":9},1,1,1,"5.9","5.9","5.9","31.371",0,"3.7752",5495100,1,"0.665464","0.38854","1.32318","1.78586","tr|B4DMI0|B4DMI0_HUMAN;tr|E9PBM2|E9PBM2_HUMAN;sp|Q8WUF8|F172A_HUMAN","tr|B4DMI0|B4DMI0_HUMAN;tr|E9PBM2|E9PBM2_HUMAN;sp|Q8WUF8|F172A_HUMAN",2139,"B4DMI0","B4DMI0_HUMAN",null,null,"FAM172A"]
["15.0631","15.0925","14.4218","13.0915",{"$nulls":3},"cellular response to insulin stimulus;insulin receptor signaling pathway via phosphatidylinositol 3-kinase;intracellular protein transmembrane transport;positive regulation of glucose import in response to insulin stimulus;positive regulation of glucose transport;positive regulation of protein targeting to membrane;positive regulation of vesicle fusion;protein localization to plasma membrane;vesicle fusion","calcium ion binding;calcium-dependent phospholipid binding","cell cortex;cytoplasmic vesicle membrane;cytosol;microtubule organizing center;plasma membrane;ruffle membrane",{"$nulls":3},1,1,1,"3.1","3.1","3.1","110.45","0.0003992","3.3496",7729100,1,"0.731751","0.348568","1.32118","1.98573","sp|Q86YS7|C2CD5_HUMAN","sp|Q86YS7|C2CD5_HUMAN",2003,"Q86YS7","C2CD5_HUMAN","C2 domain-containing protein 5",null,"C2CD5"]
["18.53","18.4394","17.2448","17.1128",{"$nulls":3},"mitochondrial ATP synthesis coupled proton transport;mitochondrial electron transport, ubiquinol to cytochrome c;response to glucagon","electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity;electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity;heme binding;metal ion binding","integral component of membrane;membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrion;nucleus","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,2,2,2,"19.7","19.7","19.7","35.422",0,"21.145",33687000,6,"2.42762","0.487027","1.3059","16.3151","sp|P08574|CY1_HUMAN","sp|P08574|CY1_HUMAN",564,"P08574","CY1_HUMAN","Cytochrome c1, heme protein, mitochondrial",null,"CYC1"]
["19.2201","19.2101","18.0775","17.7674",{"$nulls":3},"neutrophil degranulation","heme binding;steroid binding","cell body;endoplasmic reticulum;extracellular exosome;integral component of plasma membrane;membrane;neuron projection;neuronal cell body;plasma membrane;smooth endoplasmic reticulum membrane;specific granule membrane;synapse",{"$nulls":3},4,4,4,"37.9","37.9","37.9","21.671",0,"95.548",23899000,7,"1.8507","0.386667","1.29267","8.33144","sp|O00264|PGRC1_HUMAN","sp|O00264|PGRC1_HUMAN",130,"O00264","PGRC1_HUMAN","Membrane-associated progesterone receptor component 1","PR","PGRMC1"]
["18.0664","16.584","17.4542","14.6156",{"$nulls":3},"cilium assembly;developmental process;protein folding;protein localization to pericentriolar material","unfolded protein binding","cytoplasm;cytoplasmic dynein complex",{"$nulls":3},6,6,6,"24.7","24.7","24.7","40.822",0,"13.42",61779000,14,"0.296774","0.733218","1.29027","0.805829","sp|Q8IVD9|NUDC3_HUMAN","sp|Q8IVD9|NUDC3_HUMAN",2008,"Q8IVD9","NUDC3_HUMAN","NudC domain-containing protein 3",null,"NUDCD3"]
["20.8665","20.6207","19.2559","19.6715",{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,"13.7","13.7","13.7","31.745",0,"9.7485",129610000,7,"1.47119","0.323429","1.27987","5.3011","tr|H0Y6E7|H0Y6E7_HUMAN;tr|H3BT71|H3BT71_HUMAN;sp|P38159|RBMX_HUMAN;tr|H3BR27|H3BR27_HUMAN;sp|Q96E39|RMXL1_HUMAN;tr|H3BNC1|H3BNC1_HUMAN;sp|O75526|RMXL2_HUMAN;sp|Q8N7X1|RMXL3_HUMAN","tr|H0Y6E7|H0Y6E7_HUMAN;tr|H3BT71|H3BT71_HUMAN;sp|P38159|RBMX_HUMAN;tr|H3BR27|H3BR27_HUMAN;sp|Q96E39|RMXL1_HUMAN",957,"H0Y6E7","H0Y6E7_HUMAN",null,null,"RBMX"]
["21.7332","21.4383","22.5425","18.0823",{"$nulls":3},"translational initiation","RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytosol",{"$nulls":3},4,4,4,"45.1","45.1","45.1","16.46",0,"18.765",283420000,19,"0.203212","0.818971","1.27338","0.569757","sp|P47813|IF1AX_HUMAN;sp|O14602|IF1AY_HUMAN;tr|X6RAC9|X6RAC9_HUMAN;tr|A6NJH9|A6NJH9_HUMAN","sp|P47813|IF1AX_HUMAN;sp|O14602|IF1AY_HUMAN;tr|X6RAC9|X6RAC9_HUMAN;tr|A6NJH9|A6NJH9_HUMAN",162,"P47813","IF1AX_HUMAN","Eukaryotic translation initiation factor 1A, X-chromosomal","IF-1A X isoform","EIF1AX"]
["25.6701","25.7447","24.7986","24.1203",{"$nulls":3},"chromatin silencing","DNA binding;protein heterodimerization activity","extracellular exosome;nuclear chromatin;nucleosome;nucleus","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,3,3,1,"27.3","27.3","14.8","13.936",0,"43.487",1134600000,23,"1.17206","0.316685","1.24798","3.65771","sp|Q99878|H2A1J_HUMAN;sp|Q96KK5|H2A1H_HUMAN;sp|Q9BTM1|H2AJ_HUMAN;sp|Q16777|H2A2C_HUMAN;sp|Q93077|H2A1C_HUMAN;sp|Q7L7L0|H2A3_HUMAN;sp|Q6FI13|H2A2A_HUMAN;sp|P20671|H2A1D_HUMAN;sp|P0C0S8|H2A1_HUMAN;sp|P04908|H2A1B_HUMAN;tr|H0YFX9|H0YFX9_HUMAN;sp|Q96QV6|H2A1A_HUMAN;sp|P16104|H2AX_HUMAN;tr|C9J386|C9J386_HUMAN;sp|Q8IUE6|H2A2B_HUMAN","sp|Q99878|H2A1J_HUMAN;sp|Q96KK5|H2A1H_HUMAN;sp|Q9BTM1|H2AJ_HUMAN;sp|Q16777|H2A2C_HUMAN;sp|Q93077|H2A1C_HUMAN;sp|Q7L7L0|H2A3_HUMAN;sp|Q6FI13|H2A2A_HUMAN;sp|P20671|H2A1D_HUMAN;sp|P0C0S8|H2A1_HUMAN;sp|P04908|H2A1B_HUMAN;tr|H0YFX9|H0YFX9_HUMAN;sp|Q96QV6|H2A1A_HUMAN;sp|P16104|H2AX_HUMAN",506,"Q99878","H2A1J_HUMAN","Histone H2A type 1-J",null,"HIST1H2AJ"]
["17.9951","17.1477","18.2377","14.4728",{"$nulls":3},"fructose 2,6-bisphosphate metabolic process;fructose metabolic process;glucose catabolic process;glycolytic process;lactate metabolic process;positive regulation of glucokinase activity;positive regulation of glycolytic process;positive regulation of insulin secretion;response to glucose","6-phosphofructo-2-kinase activity;ATP binding;fructose-2,6-bisphosphate 2-phosphatase activity;protein kinase binding","cytosol","AMPK signaling pathway;Fructose and mannose metabolism;Metabolic pathways;Thyroid hormone signaling pathway",null,null,4,4,4,"9.5","9.5","9.5","58.476",0,"12.904",93108000,8,"0.227001","0.796535","1.21617","0.630278","sp|O60825|F262_HUMAN;tr|A0A087X278|A0A087X278_HUMAN;tr|A0A087X2H4|A0A087X2H4_HUMAN;tr|F6XNB3|F6XNB3_HUMAN;tr|F6RAZ1|F6RAZ1_HUMAN","sp|O60825|F262_HUMAN",307,"O60825","F262_HUMAN","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2","FK/FBPase 2;PF-2-K/Fru-2,6-P2ase 2","PFKFB2"]
["17.1205","17.049","16.1987","15.54",{"$nulls":3},"multicellular organism development","DNA binding;RNA binding;zinc ion binding","chromosome;cytoplasm;nucleus",{"$nulls":3},3,3,3,"4.7","4.7","4.7","117.01",0,"18.825",32655000,11,"1.17446","0.317497","1.21538","3.66893","sp|Q96KR1|ZFR_HUMAN","sp|Q96KR1|ZFR_HUMAN",2322,"Q96KR1","ZFR_HUMAN","Zinc finger RNA-binding protein","ZFR","ZFR"]
["18.7517","18.6523","18.6237","16.3595",{"$nulls":4},"metal ion transmembrane transporter activity","integral component of membrane",{"$nulls":3},1,1,1,"5.9","5.9","5.9","24.003",0,"16.31",14915000,1,"0.400875","0.62169","1.21041","1.06813","tr|A2AAT0|A2AAT0_HUMAN;tr|A0A087WTX2|A0A087WTX2_HUMAN;sp|Q92504|S39A7_HUMAN","tr|A2AAT0|A2AAT0_HUMAN;tr|A0A087WTX2|A0A087WTX2_HUMAN;sp|Q92504|S39A7_HUMAN",2164,"A2AAT0","A2AAT0_HUMAN",null,null,"SLC39A7"]
["21.7083","21.1505","19.3569","21.0929",{"$nulls":4},"ATP binding;SUMO transferase activity","cytosol",{"$nulls":3},3,3,3,"33.6","33.6","33.6","15.516",0,"8.8996",187020000,8,"0.498465","0.514091","1.20451","1.32114","tr|H3BQQ9|H3BQQ9_HUMAN;sp|P63279|UBC9_HUMAN;tr|B0QYN7|B0QYN7_HUMAN;tr|H3BPC4|H3BPC4_HUMAN","tr|H3BQQ9|H3BQQ9_HUMAN;sp|P63279|UBC9_HUMAN;tr|B0QYN7|B0QYN7_HUMAN;tr|H3BPC4|H3BPC4_HUMAN",1350,"H3BQQ9","H3BQQ9_HUMAN",null,null,"UBE2I"]
["18.3791","18.2506","17.5056","16.7251",{"$nulls":9},5,5,5,"13.3","13.3","13.3","68.054",0,"12.421",59242000,4,"1.02833","0.297492","1.19951","3.03291","tr|D6RB01|D6RB01_HUMAN;sp|Q9Y6X4|F169A_HUMAN","tr|D6RB01|D6RB01_HUMAN;sp|Q9Y6X4|F169A_HUMAN",3057,"D6RB01","D6RB01_HUMAN",null,null,"FAM169A"]
["20.0327","19.9549","18.7609","18.865",{"$nulls":3},"N-acetylneuraminate metabolic process","N-acylneuraminate cytidylyltransferase activity","membrane;nucleoplasm;nucleus","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,4,4,4,15,15,15,"48.379",0,"9.2632",131440000,16,"2.52098","0.515294","1.18087","18.1764","sp|Q8NFW8|NEUA_HUMAN","sp|Q8NFW8|NEUA_HUMAN",2098,"Q8NFW8","NEUA_HUMAN","N-acylneuraminate cytidylyltransferase",null,"CMAS"]
["18.1362","13.7085","15.0639","14.4246",{"$nulls":3},"cardiac muscle thin filament assembly","actin filament binding;cytoskeletal protein binding;filamin binding;structural constituent of muscle;tropomyosin binding","extracellular exosome;I band;stress fiber;Z disc",{"$nulls":3},3,3,3,"3.9","3.9","3.9","116.45",0,"20.764",105470000,4,"0.186431","0.834315","1.17812","0.526707","sp|O76041|NEBL_HUMAN","sp|O76041|NEBL_HUMAN",387,"O76041","NEBL_HUMAN","Nebulette",null,"NEBL"]
["23.8107","23.9931","20.9032","24.5754",{"$nulls":4},"calcium ion binding","cytosol",{"$nulls":3},3,3,3,40,40,40,"9.681",0,"29.037",559910000,30,"0.227837","0.795384","1.16259","0.632396","tr|R4GN98|R4GN98_HUMAN;sp|P06703|S10A6_HUMAN","tr|R4GN98|R4GN98_HUMAN;sp|P06703|S10A6_HUMAN",530,"R4GN98","R4GN98_HUMAN","Protein S100 {ECO:0000256|RuleBase:RU361184}",null,"S100A6"]
["22.7485","21.4509","20.4634","21.4441",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial oxoglutarate dehydrogenase complex;mitochondrial small ribosomal subunit;mitochondrion",{"$nulls":3},4,4,4,"52.4","52.4","52.4","11.466",0,"10.501",172220000,6,"0.531368","0.495615","1.14593","1.40903","sp|P82909|RT36_HUMAN;tr|D6R941|D6R941_HUMAN","sp|P82909|RT36_HUMAN",1382,"P82909","RT36_HUMAN","28S ribosomal protein S36, mitochondrial","36mt;RP-S36","MRPS36"]
["23.6047","23.4447","22.8469","21.9163",{"$nulls":3},"cellular glucose homeostasis;cellular response to X-ray;chromatin organization;double-strand break repair via homologous recombination;gene conversion;interstrand cross-link repair;modulation by host of RNA binding by virus;modulation by host of viral RNA-binding transcription factor activity;positive regulation by host of viral genome replication;positive regulation by host of viral transcription;positive regulation of insulin receptor signaling pathway;regulation of DNA replication;regulation of DNA strand elongation;regulation of insulin receptor signaling pathway;regulation of transcription from RNA polymerase II promoter;release from viral latency;replication fork processing","chromatin binding;double-stranded DNA binding;RNA binding;single-stranded DNA binding;transcription factor binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","chromatin;cytoplasm;nuclear chromatin;nucleolus;nucleus",{"$nulls":3},7,7,7,"32.5","32.5","32.5","27.296",0,"90.356",582850000,39,"0.864823","0.301754","1.14308","2.42113","sp|Q9H1E3|NUCKS_HUMAN","sp|Q9H1E3|NUCKS_HUMAN",2569,"Q9H1E3","NUCKS_HUMAN","Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1",null,"NUCKS1"]
["19.3068","18.7605","16.8336","18.9778",{"$nulls":3},"ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;microtubule-based process;negative regulation of microtubule polymerization;regulation of G2/M transition of mitotic cell cycle","calcium ion binding;GTP binding;GTPase activity;structural constituent of cytoskeleton","axoneme;cytosol;extracellular exosome;internode region of axon;microtubule;microtubule cytoskeleton;myelin sheath;neuronal cell body;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,20,3,1,"59.9","9.5","3.6","49.585",0,"5.3917",153460000,6,"0.381726","0.639877","1.12795","1.0195","sp|P04350|TBB4A_HUMAN;tr|M0R278|M0R278_HUMAN;tr|M0QY85|M0QY85_HUMAN;tr|M0QZL7|M0QZL7_HUMAN;tr|M0R0X0|M0R0X0_HUMAN;tr|M0QY37|M0QY37_HUMAN;tr|M0QX14|M0QX14_HUMAN;tr|M0QYM7|M0QYM7_HUMAN;tr|M0R042|M0R042_HUMAN;tr|M0R1I1|M0R1I1_HUMAN","sp|P04350|TBB4A_HUMAN",496,"P04350","TBB4A_HUMAN","Tubulin beta-4A chain",null,"TUBB4A"]
["15.8881","15.9638","13.5188","16.084",{"$nulls":3},"apoptotic signaling pathway;regulation of NIK/NF-kappaB signaling",null,"cytosol;nucleus",{"$nulls":3},3,3,3,"3.4","3.4","3.4","150.53",0,"7.2099",48547000,4,"0.324933","0.707291","1.1246","0.876435","tr|F5H2B9|F5H2B9_HUMAN;tr|H0YNH8|H0YNH8_HUMAN;sp|Q9BZF9|UACA_HUMAN;tr|H0YN48|H0YN48_HUMAN","tr|F5H2B9|F5H2B9_HUMAN;tr|H0YNH8|H0YNH8_HUMAN;sp|Q9BZF9|UACA_HUMAN",2519,"F5H2B9","F5H2B9_HUMAN",null,null,"UACA"]
["16.5468","16.47","15.1252","15.6471",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding","nuclear speck",{"$nulls":3},3,3,3,"8.5","8.5","8.5","77.813","0.0047361","1.9587",31971000,5,"1.29207","0.332141","1.12226","4.25497","tr|A0A0A0MSJ0|A0A0A0MSJ0_HUMAN;sp|Q86XP3|DDX42_HUMAN","tr|A0A0A0MSJ0|A0A0A0MSJ0_HUMAN;sp|Q86XP3|DDX42_HUMAN",1997,"A0A0A0MSJ0","A0A0A0MSJ0_HUMAN",null,null,"DDX42"]
["16.5801","16.3638","15.3957","15.3159",{"$nulls":3},"ribosomal small subunit biogenesis;rRNA modification;tRNA acetylation","ATP binding;N-acetyltransferase activity","nucleolus",{"$nulls":3},1,1,1,"1.8","1.8","1.8","93.533",0,"20.83",16562000,3,"1.979","0.410102","1.1161","9.68414","tr|A0A087WV29|A0A087WV29_HUMAN;sp|Q9H0A0|NAT10_HUMAN","tr|A0A087WV29|A0A087WV29_HUMAN;sp|Q9H0A0|NAT10_HUMAN",2553,"A0A087WV29","A0A087WV29_HUMAN","RNA cytidine acetyltransferase {ECO:0000256|HAMAP-Rule:MF_03211}"]
["18.5287","18.1463","17.8122","16.635",{"$nulls":9},1,1,1,"7.6","7.6","7.6","23.687","0.0011095","2.719",21857000,8,"0.670261","0.386658","1.11395","1.79999","tr|F5GYV5|F5GYV5_HUMAN;tr|H7BZV4|H7BZV4_HUMAN;tr|A0A0C4DG62|A0A0C4DG62_HUMAN;tr|F8WCT1|F8WCT1_HUMAN;tr|F5H7X4|F5H7X4_HUMAN;sp|Q66PJ3|AR6P4_HUMAN","tr|F5GYV5|F5GYV5_HUMAN;tr|H7BZV4|H7BZV4_HUMAN;tr|A0A0C4DG62|A0A0C4DG62_HUMAN;tr|F8WCT1|F8WCT1_HUMAN;tr|F5H7X4|F5H7X4_HUMAN;sp|Q66PJ3|AR6P4_HUMAN",1857,"F5GYV5","F5GYV5_HUMAN",null,null,"ARL6IP4"]
["23.9894","20.7491","21.7392","20.7732",{"$nulls":3},"canonical glycolysis;gluconeogenesis;glycolytic process","magnesium ion binding;phosphopyruvate hydratase activity","cytosol;extracellular exosome;extracellular space;membrane;myelin sheath;perikaryon;phosphopyruvate hydratase complex;photoreceptor inner segment;plasma membrane","Biosynthesis of amino acids;Carbon metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;RNA degradation",null,null,8,7,7,"32.9","28.8","28.8","47.268",0,"235.91",760720000,52,"0.238103","0.787572","1.11302","0.658362","sp|P09104|ENOG_HUMAN;tr|F5H0C8|F5H0C8_HUMAN;tr|F5H1C3|F5H1C3_HUMAN;tr|U3KQP4|U3KQP4_HUMAN","sp|P09104|ENOG_HUMAN;tr|F5H0C8|F5H0C8_HUMAN;tr|F5H1C3|F5H1C3_HUMAN",577,"P09104","ENOG_HUMAN","Gamma-enolase",null,"ENO2"]
["18.4472","19.3434","17.0536","18.5156",{"$nulls":3},"apoptotic process;negative regulation of transcription, DNA-templated;positive regulation of response to DNA damage stimulus",null,"nuclear speck",{"$nulls":3},4,4,4,"6.2","6.2","6.2","83.134",0,"11.775",96404000,8,"0.488709","0.524247","1.1107","1.29537","tr|E9PK09|E9PK09_HUMAN;tr|E9PQN2|E9PQN2_HUMAN;tr|E9PKI6|E9PKI6_HUMAN;tr|E9PK91|E9PK91_HUMAN;sp|Q9NYF8|BCLF1_HUMAN;tr|E9PJA7|E9PJA7_HUMAN;tr|H0YF00|H0YF00_HUMAN","tr|E9PK09|E9PK09_HUMAN;tr|E9PQN2|E9PQN2_HUMAN;tr|E9PKI6|E9PKI6_HUMAN;tr|E9PK91|E9PK91_HUMAN;sp|Q9NYF8|BCLF1_HUMAN;tr|E9PJA7|E9PJA7_HUMAN",2749,"E9PK09","E9PK09_HUMAN",null,null,"BCLAF1"]
["20.7326","20.4634","21.7247","17.2887",{"$nulls":3},"ATP synthesis coupled proton transport","hydrogen ion transmembrane transporter activity","integral component of membrane;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);mitochondrion;nucleoplasm",{"$nulls":3},3,3,3,"17.9","17.9","17.9","22.275",0,"21.512",145810000,6,"0.172668","0.849259","1.09131","0.491124","tr|Q5QNZ2|Q5QNZ2_HUMAN;sp|P24539|AT5F1_HUMAN","tr|Q5QNZ2|Q5QNZ2_HUMAN;sp|P24539|AT5F1_HUMAN",789,"Q5QNZ2","Q5QNZ2_HUMAN",null,null,"ATP5PB"]
["15.1635","14.9023","14.0786","13.8145",{"$nulls":3},"chromatin organization;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;neural tube development;neurogenesis;nuclear pore distribution;nuclear pore organization;paraxial mesoderm development;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of transcription, DNA-templated;sister chromatid cohesion;somite development;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;tRNA export from nucleus;viral process;viral transcription","nucleocytoplasmic transporter activity;structural constituent of nuclear pore","condensed chromosome kinetochore;cytosol;host cell;membrane;nuclear envelope;nuclear membrane;nuclear pore;nuclear pore outer ring","RNA transport",null,null,1,1,1,"0.8","0.8","0.8","128.98","0.002771","2.1727",12978000,3,"1.55276","0.330667","1.08636","5.84936","sp|Q8WUM0|NU133_HUMAN","sp|Q8WUM0|NU133_HUMAN",2140,"Q8WUM0","NU133_HUMAN","Nuclear pore complex protein Nup133",null,"NUP133"]
["19.9797","20.0633","17.8151","20.1061",{"$nulls":3},"DNA damage response, detection of DNA damage;mitochondrial translational elongation;mitochondrial translational termination","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit",{"$nulls":3},4,4,4,"21.1","21.1","21.1","36.844",0,"40.472",140430000,13,"0.344471","0.690167","1.06088","0.925508","sp|P82673|RT35_HUMAN;tr|H0YG82|H0YG82_HUMAN","sp|P82673|RT35_HUMAN",1380,"P82673","RT35_HUMAN","28S ribosomal protein S35, mitochondrial","35mt;RP-S35","MRPS35"]
["18.3826","20.154","18.6707","17.7445",{"$nulls":5},"mitochondrion;nucleus",{"$nulls":3},2,2,2,"8.7","8.7","8.7","23.128",0,"4.9853",97868000,7,"0.39817","0.622817","1.0607","1.06125","sp|Q8WW59|SPRY4_HUMAN","sp|Q8WW59|SPRY4_HUMAN",2149,"Q8WW59","SPRY4_HUMAN","SPRY domain-containing protein 4",null,"SPRYD4"]
["17.0027","16.3623","17.1186","14.168",{"$nulls":9},2,2,2,"6.3","6.3","6.3","56.946",0,"3.6977",22091000,1,"0.250016","0.774181","1.03926","0.688411","tr|F8WE53|F8WE53_HUMAN;tr|F8WAH1|F8WAH1_HUMAN;sp|Q9UDR5|AASS_HUMAN","tr|F8WE53|F8WE53_HUMAN;tr|F8WAH1|F8WAH1_HUMAN;sp|Q9UDR5|AASS_HUMAN",2813,"F8WE53","F8WE53_HUMAN",null,null,"AASS"]
["20.8715","21.0247","20.1331","19.6953",{"$nulls":3},"carbohydrate metabolic process;neutrophil degranulation;protein folding","carbohydrate binding;enzyme binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;plasma membrane;specific granule membrane",{"$nulls":3},4,4,4,"14.7","14.7","14.7","32.233",0,"90.268",167990000,20,"1.32961","0.333869","1.03393","4.45783","sp|Q14165|MLEC_HUMAN;tr|F5H1S8|F5H1S8_HUMAN;tr|F5GX14|F5GX14_HUMAN;tr|H0YG07|H0YG07_HUMAN","sp|Q14165|MLEC_HUMAN;tr|F5H1S8|F5H1S8_HUMAN;tr|F5GX14|F5GX14_HUMAN",1607,"Q14165","MLEC_HUMAN","Malectin",null,"MLEC"]
["19.4067","20.0089","19.1737","18.1894",{"$nulls":3},"regulation of cell proliferation","hydrolase activity","cytoplasm;extracellular exosome;nucleoplasm",{"$nulls":3},1,1,1,"6.5","6.5","6.5",21,0,"4.8248",37923000,4,"0.663016","0.388979","1.02622","1.77867","sp|O75884|RBBP9_HUMAN","sp|O75884|RBBP9_HUMAN",374,"O75884","RBBP9_HUMAN","Putative hydrolase RBBP9",null,"RBBP9"]
["19.1503","19.6175","18.9759","17.7466",{"$nulls":4},"metal ion binding;RNA binding","nucleolus;nucleus",{"$nulls":3},1,1,1,"4.7","4.7","4.7","43.614",0,"3.8769",59897000,7,"0.584752","0.450992","1.02259","1.55515","sp|Q9NX58|LYAR_HUMAN","sp|Q9NX58|LYAR_HUMAN",2736,"Q9NX58","LYAR_HUMAN","Cell growth-regulating nucleolar protein",null,"LYAR"]
["20.7706","20.3172","20.2637","18.785",{"$nulls":3},"intracellular protein transport",null,"intracellular",{"$nulls":3},7,7,7,"39.1","39.1","39.1","29.163",0,"31.135",261650000,34,"0.497393","0.515284","1.01949","1.3183","tr|M0R0Y2|M0R0Y2_HUMAN;sp|P54920|SNAA_HUMAN;tr|M0R2M1|M0R2M1_HUMAN;tr|M0R213|M0R213_HUMAN;tr|M0R027|M0R027_HUMAN;tr|M0QZM9|M0QZM9_HUMAN;tr|M0QZN5|M0QZN5_HUMAN;tr|M0R031|M0R031_HUMAN;tr|M0R058|M0R058_HUMAN;tr|M0R0I4|M0R0I4_HUMAN;sp|Q9H115|SNAB_HUMAN;tr|A0A087WZQ7|A0A087WZQ7_HUMAN","tr|M0R0Y2|M0R0Y2_HUMAN;sp|P54920|SNAA_HUMAN;tr|M0R2M1|M0R2M1_HUMAN",1200,"M0R0Y2","M0R0Y2_HUMAN",null,null,"NAPA"]
["21.992","21.977","20.6731","21.2773",{"$nulls":4},"calcium ion binding",{"$nulls":4},2,2,2,"17.4","17.4","17.4","18.445",0,"44.553",264240000,20,"1.10156","0.308984","1.00924","3.33995","tr|U3KQE2|U3KQE2_HUMAN;tr|K7EM73|K7EM73_HUMAN;tr|K7EIV0|K7EIV0_HUMAN;tr|A0A075B7C0|A0A075B7C0_HUMAN;sp|P04632|CPNS1_HUMAN;tr|A0A0C4DGQ5|A0A0C4DGQ5_HUMAN;tr|U3KPR7|U3KPR7_HUMAN;tr|K7EKD8|K7EKD8_HUMAN;tr|K7ELJ7|K7ELJ7_HUMAN","tr|U3KQE2|U3KQE2_HUMAN;tr|K7EM73|K7EM73_HUMAN;tr|K7EIV0|K7EIV0_HUMAN;tr|A0A075B7C0|A0A075B7C0_HUMAN;sp|P04632|CPNS1_HUMAN;tr|A0A0C4DGQ5|A0A0C4DGQ5_HUMAN;tr|U3KPR7|U3KPR7_HUMAN;tr|K7EKD8|K7EKD8_HUMAN;tr|K7ELJ7|K7ELJ7_HUMAN",499,"U3KQE2","U3KQE2_HUMAN",null,null,"CAPNS1"]
["20.3027","20.0203","18.8729","19.4332",{"$nulls":3},"heart development;intraciliary transport involved in cilium assembly;left/right axis specification;lung development;skeletal system development;smoothened signaling pathway","metal ion binding","centrosome;ciliary tip;cilium;extracellular exosome;intraciliary transport particle B",{"$nulls":3},1,1,1,"17.4","17.4","17.4","16.297","0.0010657","2.3623",60481000,8,"1.07219","0.304632","1.00846","3.21409","sp|Q9Y547|IFT25_HUMAN","sp|Q9Y547|IFT25_HUMAN",3011,"Q9Y547","IFT25_HUMAN","Intraflagellar transport protein 25 homolog",null,"HSPB11"]
["17.7095","17.6238","16.4897","16.8275",{"$nulls":3},"L-methionine salvage from methylthioadenosine","identical protein binding;S-methyl-5-thioribose-1-phosphate isomerase activity","cell projection;cytosol;fibrillar center;nucleoplasm","Cysteine and methionine metabolism;Metabolic pathways",null,null,2,2,2,"8.1","8.1","8.1","39.149","0.0011152","2.758",37570000,2,"1.54356","0.320145","1.00804","5.78499","sp|Q9BV20|MTNA_HUMAN","sp|Q9BV20|MTNA_HUMAN",2463,"Q9BV20","MTNA_HUMAN","Methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119}","1Pi {ECO:0000255|HAMAP-Rule:MF_03119};TR-1-P isomerase {ECO:0000255|HAMAP-Rule:MF_03119}","MRI1"]
["20.8703","20.9734","20.2967","19.5632",{"$nulls":9},1,1,1,"16.5","16.5","16.5","10.172",0,"40.527",29388000,8,"0.936655","0.298229","0.991896","2.67834","tr|F5H079|F5H079_HUMAN;tr|A0A087X114|A0A087X114_HUMAN;tr|S4R3Z1|S4R3Z1_HUMAN;tr|F5H4Z7|F5H4Z7_HUMAN;sp|Q96EY8|MMAB_HUMAN","tr|F5H079|F5H079_HUMAN;tr|A0A087X114|A0A087X114_HUMAN;tr|S4R3Z1|S4R3Z1_HUMAN;tr|F5H4Z7|F5H4Z7_HUMAN;sp|Q96EY8|MMAB_HUMAN",2267,"F5H079","F5H079_HUMAN",null,null,"MMAB"]
["18.3152","18.9251","18.4096","16.8667",{"$nulls":4},"calcium ion binding;calcium-dependent phospholipid binding",{"$nulls":4},15,1,1,"39.8",3,3,"51.776",0,"12.792",61633000,3,"0.445951","0.555935","0.981995","1.18376","tr|E5RK69|E5RK69_HUMAN","tr|E5RK69|E5RK69_HUMAN",3081,"E5RK69","E5RK69_HUMAN","Annexin {ECO:0000256|RuleBase:RU003540}",null,"ANXA6"]
["18.0721","17.8229","17.8729","16.0997",{"$nulls":3},"cell division;ciliary basal body-plasma membrane docking;cytoskeleton-dependent intracellular transport;G2/M transition of mitotic cell cycle;microtubule-based process;regulation of G2/M transition of mitotic cell cycle","GTP binding;GTPase activity;protein domain specific binding;structural constituent of cytoskeleton;structural molecule activity","cytoplasmic microtubule;cytoplasmic ribonucleoprotein granule;cytosol;extracellular exosome;membrane raft;microtubule;microtubule cytoskeleton;myelin sheath;nucleus;recycling endosome","Apoptosis;Gap junction;Pathogenic Escherichia coli infection;Phagosome;Tight junction",null,null,21,2,1,"58.3",6,"3.1","50.135",0,"4.6042",56239000,5,"0.40304","0.618181","0.961226","1.07364","sp|Q71U36|TBA1A_HUMAN;sp|Q13748|TBA3C_HUMAN;sp|Q6PEY2|TBA3E_HUMAN;tr|F8VQQ4|F8VQQ4_HUMAN;tr|V9GZ17|V9GZ17_HUMAN","sp|Q71U36|TBA1A_HUMAN;sp|Q13748|TBA3C_HUMAN;sp|Q6PEY2|TBA3E_HUMAN;tr|F8VQQ4|F8VQQ4_HUMAN",1925,"Q71U36","TBA1A_HUMAN","Tubulin alpha-1A chain",null,"TUBA1A"]
["16.9725","17.3438","16.651","15.7643",{"$nulls":3},"cell redox homeostasis;IRE1-mediated unfolded protein response;oxidation-reduction process;protein folding;response to endoplasmic reticulum stress","oxidoreductase activity;peptide disulfide oxidoreductase activity;protein disulfide isomerase activity","endoplasmic reticulum lumen;endoplasmic reticulum membrane",{"$nulls":3},1,1,1,"6.6","6.6","6.6","59.594",0,"10.5",25064000,5,"0.729084","0.350138","0.950503","1.97749","sp|Q14554|PDIA5_HUMAN","sp|Q14554|PDIA5_HUMAN",1627,"Q14554","PDIA5_HUMAN","Protein disulfide-isomerase A5",null,"PDIA5"]
["15.8159","15.9946","15.1693","14.7429",{"$nulls":9},1,1,1,"1.6","1.6","1.6","108.34","0.0075484","1.7443",25009000,1,"1.26346","0.326659","0.9491","4.10569","tr|A0A087X0S5|A0A087X0S5_HUMAN;sp|P12109|CO6A1_HUMAN","tr|A0A087X0S5|A0A087X0S5_HUMAN;sp|P12109|CO6A1_HUMAN",641,"A0A087X0S5","A0A087X0S5_HUMAN",null,null,"COL6A1"]
["24.3394","24.3303","23.5868","23.2031",{"$nulls":3},"aging;antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;chaperone-mediated protein folding;clathrin-dependent endocytosis;interleukin-12-mediated signaling pathway;protein folding;protein folding in endoplasmic reticulum;protein secretion;synaptic vesicle endocytosis","apolipoprotein binding;calcium ion binding;carbohydrate binding;ionotropic glutamate receptor binding;RNA binding;unfolded protein binding","axon;dendrite cytoplasm;dendritic spine;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;ER-mitochondrion membrane contact site;extracellular exosome;extracellular matrix;integral component of lumenal side of endoplasmic reticulum membrane;melanosome;membrane;myelin sheath;neuronal cell body;protein complex;ribosome;rough endoplasmic reticulum;smooth endoplasmic reticulum","Antigen processing and presentation;Human T-cell leukemia virus 1 infection;Phagosome;Protein processing in endoplasmic reticulum;Thyroid hormone synthesis",null,null,18,18,18,"32.1","32.1","32.1","67.567",0,"323.31",4369500000,145,"1.40609","0.331669","0.939934","4.8973","sp|P27824|CALX_HUMAN;tr|H0Y9Q7|H0Y9Q7_HUMAN;tr|D6RGY2|D6RGY2_HUMAN;tr|D6RFL1|D6RFL1_HUMAN;tr|D6RAU8|D6RAU8_HUMAN;tr|D6RB85|D6RB85_HUMAN;tr|D6RDP7|D6RDP7_HUMAN;tr|H0Y9H1|H0Y9H1_HUMAN;tr|D6RHJ3|D6RHJ3_HUMAN;tr|D6RD16|D6RD16_HUMAN;tr|D6RAQ8|D6RAQ8_HUMAN","sp|P27824|CALX_HUMAN",830,"P27824","CALX_HUMAN","Calnexin",null,"CANX"]
["17.0815","17.5138","16.5138","16.2231",{"$nulls":3},"actin filament organization;female gamete generation","actin binding;Rho GTPase binding","endoplasmic reticulum;intracellular membrane-bounded organelle;nucleolus",{"$nulls":3},2,2,2,"3.7","3.7","3.7","124.85","0.00076805","2.9976",57364000,5,"1.15254","0.309","0.929199","3.56741","tr|A6NML8|A6NML8_HUMAN;tr|K4DI95|K4DI95_HUMAN;sp|O60879|DIAP2_HUMAN;tr|C9J6U3|C9J6U3_HUMAN","tr|A6NML8|A6NML8_HUMAN;tr|K4DI95|K4DI95_HUMAN;sp|O60879|DIAP2_HUMAN;tr|C9J6U3|C9J6U3_HUMAN",312,"A6NML8","A6NML8_HUMAN"]
["19.9797","20.1125","19.5224","18.7161",{"$nulls":5},"ribosome",{"$nulls":3},3,3,3,"13.1","13.1","13.1","41.329",0,"19.628",148240000,18,"0.819866","0.321178","0.926862","2.26845","tr|G5EA06|G5EA06_HUMAN;sp|Q92552|RT27_HUMAN;tr|D6RH20|D6RH20_HUMAN","tr|G5EA06|G5EA06_HUMAN;sp|Q92552|RT27_HUMAN;tr|D6RH20|D6RH20_HUMAN",2172,"G5EA06","G5EA06_HUMAN"]
["19.3788","18.0811","19.0206","16.5856",{"$nulls":9},2,2,2,"22.2","22.2","22.2","18.246","0.0085023","1.7217",42225000,3,"0.243436","0.784761","0.926836","0.671824","tr|B8ZZI0|B8ZZI0_HUMAN;tr|E7EXA3|E7EXA3_HUMAN;tr|Q6X734|Q6X734_HUMAN;sp|Q9GZT8|NIF3L_HUMAN;tr|C9JN42|C9JN42_HUMAN","tr|B8ZZI0|B8ZZI0_HUMAN;tr|E7EXA3|E7EXA3_HUMAN;tr|Q6X734|Q6X734_HUMAN;sp|Q9GZT8|NIF3L_HUMAN;tr|C9JN42|C9JN42_HUMAN",2543,"B8ZZI0","B8ZZI0_HUMAN",null,null,"NIF3L1"]
["21.0042","20.9485","20.5209","19.5817",{"$nulls":3},"mRNA processing;RNA splicing","DNA binding transcription factor activity;metal ion binding;RNA binding","nucleoplasm;nucleus",{"$nulls":3},4,4,4,"14.8","14.8","14.8","37.404",0,"54.461",217380000,26,"0.725547","0.353149","0.925076","1.96658","sp|O95218|ZRAB2_HUMAN;tr|A0A0C4DGV5|A0A0C4DGV5_HUMAN","sp|O95218|ZRAB2_HUMAN;tr|A0A0C4DGV5|A0A0C4DGV5_HUMAN",418,"O95218","ZRAB2_HUMAN","Zinc finger Ran-binding domain-containing protein 2",null,"ZRANB2"]
["18.8623","18.6319","18.9431","16.7213",{"$nulls":9},2,2,2,"11.8","11.8","11.8","30.723",0,"8.3484",58563000,8,"0.302069","0.727135","0.914823","0.819101","tr|F8WBF9|F8WBF9_HUMAN;sp|Q9UGV2|NDRG3_HUMAN;tr|Q5TH30|Q5TH30_HUMAN","tr|F8WBF9|F8WBF9_HUMAN;sp|Q9UGV2|NDRG3_HUMAN;tr|Q5TH30|Q5TH30_HUMAN",2824,"F8WBF9","F8WBF9_HUMAN",null,null,"NDRG3"]
["19.8643","20.314","19.5177","18.837",{"$nulls":3},"apoptotic process;ER to Golgi vesicle-mediated transport;intracellular protein transport;osteoblast differentiation;protein localization to endoplasmic reticulum exit site",null,"endoplasmic reticulum membrane;integral component of membrane;membrane",{"$nulls":3},3,3,1,"14.5","14.5","4.6","28.32",0,"35.062",104720000,11,"0.809868","0.326347","0.911817","2.2353","sp|Q9UHQ4|BAP29_HUMAN;tr|B7Z2L0|B7Z2L0_HUMAN;tr|C9JTE9|C9JTE9_HUMAN;tr|C9JGJ9|C9JGJ9_HUMAN;tr|H0Y7N8|H0Y7N8_HUMAN;tr|F8WB99|F8WB99_HUMAN;tr|C9IYK6|C9IYK6_HUMAN","sp|Q9UHQ4|BAP29_HUMAN;tr|B7Z2L0|B7Z2L0_HUMAN;tr|C9JTE9|C9JTE9_HUMAN",2838,"Q9UHQ4","BAP29_HUMAN","B-cell receptor-associated protein 29","ap29;CR-associated protein 29","BCAP29"]
["21.3894","21.7778","20.8147","20.5317",{"$nulls":3},"cerebellar granule cell precursor proliferation;proteasome assembly;proteasome core complex assembly","proteasome binding","cytoplasm;cytosol;endoplasmic reticulum;Golgi apparatus;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"11.8","11.8","11.8","32.854",0,"97.058",293260000,7,"1.19972","0.326087","0.910336","3.78879","sp|O95456|PSMG1_HUMAN;tr|F8WBH7|F8WBH7_HUMAN","sp|O95456|PSMG1_HUMAN;tr|F8WBH7|F8WBH7_HUMAN",436,"O95456","PSMG1_HUMAN","Proteasome assembly chaperone 1","AC-1","PSMG1"]
["16.6007","16.868","16.2127","15.446",{"$nulls":4},"catalytic activity","intracellular membrane-bounded organelle;plasma membrane",{"$nulls":3},1,1,1,"7.9","7.9","7.9","40.674","0.0047313","1.9476",8560700,3,"0.80801","0.325111","0.90499","2.22917","tr|D6RB81|D6RB81_HUMAN;sp|Q9UHK6|AMACR_HUMAN","tr|D6RB81|D6RB81_HUMAN;sp|Q9UHK6|AMACR_HUMAN",2835,"D6RB81","D6RB81_HUMAN",null,null,"AMACR"]
["22.6007","22.5413","22.3856","20.9502",{"$nulls":9},4,4,4,"31.9","31.9","31.9","19.416",0,"97.271",462190000,21,"0.474162","0.530785","0.903059","1.25716","tr|A0A096LNH5|A0A096LNH5_HUMAN;tr|H7C2G3|H7C2G3_HUMAN;tr|A0A0B4J2H4|A0A0B4J2H4_HUMAN;tr|H7C1F6|H7C1F6_HUMAN;tr|A0A0B4J2D5|A0A0B4J2D5_HUMAN;sp|P30042|ES1_HUMAN;tr|A0A096LPI6|A0A096LPI6_HUMAN;tr|A0A096LNJ1|A0A096LNJ1_HUMAN;tr|A0A096LP73|A0A096LP73_HUMAN;tr|F2Z2Q0|F2Z2Q0_HUMAN;tr|A0A096LP12|A0A096LP12_HUMAN","tr|A0A096LNH5|A0A096LNH5_HUMAN;tr|H7C2G3|H7C2G3_HUMAN;tr|A0A0B4J2H4|A0A0B4J2H4_HUMAN;tr|H7C1F6|H7C1F6_HUMAN;tr|A0A0B4J2D5|A0A0B4J2D5_HUMAN;sp|P30042|ES1_HUMAN;tr|A0A096LPI6|A0A096LPI6_HUMAN;tr|A0A096LNJ1|A0A096LNJ1_HUMAN;tr|A0A096LP73|A0A096LP73_HUMAN;tr|F2Z2Q0|F2Z2Q0_HUMAN;tr|A0A096LP12|A0A096LP12_HUMAN",856,"A0A096LNH5","A0A096LNH5_HUMAN",null,null,"LOC102724023"]
["19.3273","19.1061","16.9151","19.7162",{"$nulls":4},"ATP binding;protein kinase activity","cytosol;nucleolus",{"$nulls":3},3,3,2,"11.1","11.1","6.8","40.781",0,"6.6114",90615000,10,"0.231366","0.792545","0.901031","0.641331","tr|H0Y630|H0Y630_HUMAN;tr|B4DR80|B4DR80_HUMAN;sp|Q9Y6E0|STK24_HUMAN;tr|Q5JV98|Q5JV98_HUMAN","tr|H0Y630|H0Y630_HUMAN;tr|B4DR80|B4DR80_HUMAN;sp|Q9Y6E0|STK24_HUMAN",3048,"H0Y630","H0Y630_HUMAN",null,null,"STK24"]
["21.213","20.8433","20.576","19.6832",{"$nulls":3},"ductus arteriosus closure;female pregnancy;kidney development;lipoxin metabolic process;lipoxygenase pathway;negative regulation of cell cycle;ovulation;parturition;positive regulation of apoptotic process;positive regulation of vascular smooth muscle cell proliferation;prostaglandin metabolic process;response to estradiol;response to ethanol;response to lipopolysaccharide;thrombin-activated receptor signaling pathway;transforming growth factor beta receptor signaling pathway","15-hydroxyprostaglandin dehydrogenase (NAD+) activity;catalytic activity;NAD binding;NAD+ binding;prostaglandin E receptor activity;protein homodimerization activity","basolateral plasma membrane;cytosol;extracellular exosome;nucleoplasm","Transcriptional misregulation in cancer",null,null,4,4,4,"19.5","19.5","19.5","28.977",0,"9.5921",272160000,21,"0.690382","0.373542","0.898549","1.85981","sp|P15428|PGDH_HUMAN;tr|E9PBZ2|E9PBZ2_HUMAN;tr|E9PD69|E9PD69_HUMAN;tr|D6RHF8|D6RHF8_HUMAN;tr|D6RA66|D6RA66_HUMAN;tr|D6RA83|D6RA83_HUMAN","sp|P15428|PGDH_HUMAN;tr|E9PBZ2|E9PBZ2_HUMAN;tr|E9PD69|E9PD69_HUMAN",684,"P15428","PGDH_HUMAN","15-hydroxyprostaglandin dehydrogenase [NAD(+)]","5-PGDH","HPGD"]
["20.5922","20.6443","19.2237","20.2175",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;COPII vesicle coating;ER to Golgi vesicle-mediated transport;intracellular protein transport","GTP binding;GTPase activity;metal ion binding","cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi cisterna membrane","Legionellosis;Protein processing in endoplasmic reticulum",null,null,3,1,1,"15.2","5.6","5.6","22.41",0,"17.399",197070000,11,"0.671623","0.384115","0.897676","1.80401","sp|Q9Y6B6|SAR1B_HUMAN;tr|Q9H029|Q9H029_HUMAN;tr|D6RD69|D6RD69_HUMAN;tr|D6R9R5|D6R9R5_HUMAN","sp|Q9Y6B6|SAR1B_HUMAN;tr|Q9H029|Q9H029_HUMAN;tr|D6RD69|D6RD69_HUMAN",3044,"Q9Y6B6","SAR1B_HUMAN","GTP-binding protein SAR1b",null,"SAR1B"]
["22.4549","22.4987","22.1014","21.0958",{"$nulls":3},"formation of translation preinitiation complex;IRES-dependent viral translational initiation;ribosome disassembly;translation reinitiation","mRNA binding;ribosome binding;translation initiation factor activity","translation initiation complex",{"$nulls":3},3,3,3,"17.7","17.7","17.7","22.092",0,"121.45",281010000,14,"0.651475","0.392094","0.87818","1.74494","sp|O43583|DENR_HUMAN;tr|F8VVL1|F8VVL1_HUMAN","sp|O43583|DENR_HUMAN;tr|F8VVL1|F8VVL1_HUMAN",250,"O43583","DENR_HUMAN","Density-regulated protein","RP","DENR"]
["19.2329","16.6293","17.7872","16.3279",{"$nulls":3},"cell proliferation;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);Notch signaling pathway;ribosomal large subunit biogenesis;rRNA processing",null,"nucleolus;nucleoplasm;PeBoW complex;preribosome, large subunit precursor",{"$nulls":3},2,2,2,9,9,9,"47.707",0,"3.9223",80044000,5,"0.209309","0.814166","0.873498","0.58532","sp|Q9GZL7|WDR12_HUMAN","sp|Q9GZL7|WDR12_HUMAN",2533,"Q9GZL7","WDR12_HUMAN","Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}",null,"WDR12"]
["20.1196","20.3442","20.7861","17.9648",{"$nulls":9},3,3,3,"20.4","20.4","20.4","23.993",0,"35.746",130800000,12,"0.217115","0.80262","0.856413","0.605191","tr|Q9H7D3|Q9H7D3_HUMAN;tr|H3BSP8|H3BSP8_HUMAN;tr|H3BTU3|H3BTU3_HUMAN;sp|Q9BQ70|TCF25_HUMAN;tr|H3BS87|H3BS87_HUMAN;tr|H3BMJ8|H3BMJ8_HUMAN;tr|H3BSS3|H3BSS3_HUMAN;tr|H3BQ53|H3BQ53_HUMAN","tr|Q9H7D3|Q9H7D3_HUMAN;tr|H3BSP8|H3BSP8_HUMAN;tr|H3BTU3|H3BTU3_HUMAN;sp|Q9BQ70|TCF25_HUMAN;tr|H3BS87|H3BS87_HUMAN;tr|H3BMJ8|H3BMJ8_HUMAN",2416,"Q9H7D3","Q9H7D3_HUMAN",null,null,"TCF25"]
["16.9697","16.9742","17.2559","14.9969",{"$nulls":3},"glycolipid metabolic process","glucosyltransferase activity","endoplasmic reticulum lumen",{"$nulls":3},3,3,3,"7.1","7.1","7.1","58.572",0,"7.386",37705000,6,"0.273965","0.755046","0.845563","0.748622","sp|Q7Z4H8|KDEL2_HUMAN","sp|Q7Z4H8|KDEL2_HUMAN",1955,"Q7Z4H8","KDEL2_HUMAN","KDEL motif-containing protein 2",null,"KDELC2"]
["17.2973","17.3092","16.5026","16.4206",{"$nulls":4},"magnesium ion binding;thiamine pyrophosphate binding",{"$nulls":4},1,1,1,10,10,10,"25.463",0,"3.9937",15417000,5,"2.61666","0.574426","0.841677","20.3022","tr|M0QZX5|M0QZX5_HUMAN;tr|M0R026|M0R026_HUMAN;sp|A1L0T0|ILVBL_HUMAN","tr|M0QZX5|M0QZX5_HUMAN;tr|M0R026|M0R026_HUMAN;sp|A1L0T0|ILVBL_HUMAN",96,"M0QZX5","M0QZX5_HUMAN",null,null,"ILVBL"]
["18.2291","18.5518","17.9247","17.2604",{"$nulls":9},1,1,1,"9.9","9.9","9.9","14.043","0.0047329","1.9495",13125000,1,"0.78702","0.33398","0.797894","2.16061","tr|H0Y9N4|H0Y9N4_HUMAN;tr|D6RC04|D6RC04_HUMAN;tr|D6RJ90|D6RJ90_HUMAN;sp|Q9Y6G5|COMDA_HUMAN","tr|H0Y9N4|H0Y9N4_HUMAN;tr|D6RC04|D6RC04_HUMAN;tr|D6RJ90|D6RJ90_HUMAN;sp|Q9Y6G5|COMDA_HUMAN",3050,"H0Y9N4","H0Y9N4_HUMAN",null,null,"COMMD10"]
["18.1255","19.4076","18.666","17.2746",{"$nulls":3},"acute-phase response;cholesterol metabolic process;lipid metabolic process;lipid transport;lipoprotein metabolic process;maternal process involved in female pregnancy;multicellular organism development","high-density lipoprotein particle binding;lipid binding;receptor binding","endoplasmic reticulum membrane;extracellular region;membrane",{"$nulls":3},4,4,4,"12.2","12.2","12.2","37.092",0,"43.122",176420000,10,"0.311074","0.715364","0.796238","0.841675","sp|Q9BQE5|APOL2_HUMAN;tr|J3KQL8|J3KQL8_HUMAN;tr|E9PM95|E9PM95_HUMAN;tr|B0QYK8|B0QYK8_HUMAN","sp|Q9BQE5|APOL2_HUMAN;tr|J3KQL8|J3KQL8_HUMAN;tr|E9PM95|E9PM95_HUMAN",2419,"Q9BQE5","APOL2_HUMAN","Apolipoprotein L2",null,"APOL2"]
["16.5632","16.2833","15.9404","15.3147",{"$nulls":3},"RNA processing",{"$nulls":5},2,2,2,"3.2","3.2","3.2","99.172",0,"3.5518",32258000,3,"0.835815","0.313609","0.795723","2.32192","tr|Q5JY65|Q5JY65_HUMAN;sp|Q9BZJ0|CRNL1_HUMAN","tr|Q5JY65|Q5JY65_HUMAN;sp|Q9BZJ0|CRNL1_HUMAN",2521,"Q5JY65","Q5JY65_HUMAN",null,null,"CRNKL1"]
["17.0251","17.2268","16.7634","15.9",{"$nulls":3},"oligosaccharide metabolic process;protein folding;protein N-linked glycosylation","glucosidase activity;mannosyl-oligosaccharide glucosidase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;membrane","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,3,3,3,"6.9","6.9","6.9","91.916",0,"15.221",39016000,15,"0.667355","0.388619","0.79424","1.79143","sp|Q13724|MOGS_HUMAN;tr|C9J8D4|C9J8D4_HUMAN;tr|C9JDQ1|C9JDQ1_HUMAN;tr|B8ZZE2|B8ZZE2_HUMAN","sp|Q13724|MOGS_HUMAN;tr|C9J8D4|C9J8D4_HUMAN",1586,"Q13724","MOGS_HUMAN","Mannosyl-oligosaccharide glucosidase",null,"MOGS"]
["19.6264","19.4053","19.5236","17.9228",{"$nulls":3},"cell cycle;cellular response to tumor cell;keratinocyte differentiation;negative regulation of cell division;negative regulation of transcription from RNA polymerase II promoter;platelet-derived growth factor receptor signaling pathway;positive regulation of apoptotic process;protein import into nucleus;regulation of cell proliferation;response to calcium ion;response to drug;response to estradiol;response to glucose;response to hydrogen peroxide;response to mechanical stimulus;response to progesterone;transcription, DNA-templated","enzyme inhibitor activity;ubiquitin protein ligase binding","cytoplasm;cytosol;mitochondrial intermembrane space;nucleus","NOD-like receptor signaling pathway",null,null,2,2,2,"9.2","9.2","9.2","43.661",0,"7.3192",71371000,6,"0.366516","0.662702","0.792664","0.981043","sp|Q9H3M7|TXNIP_HUMAN","sp|Q9H3M7|TXNIP_HUMAN",2587,"Q9H3M7","TXNIP_HUMAN","Thioredoxin-interacting protein",null,"TXNIP"]
["17.547","17.7529","16.8574","16.8625",{"$nulls":3},"anastral spindle assembly;astral microtubule organization;cell division;chromosome segregation;establishment of mitotic spindle orientation;meiotic cell cycle;microtubule bundle formation;nucleus organization;positive regulation of BMP signaling pathway;positive regulation of chromosome segregation;positive regulation of chromosome separation;positive regulation of hair follicle development;positive regulation of intracellular transport;positive regulation of keratinocyte differentiation;positive regulation of microtubule polymerization;positive regulation of mitotic spindle elongation;positive regulation of protein localization to cell cortex;positive regulation of protein localization to spindle pole body;positive regulation of spindle assembly;regulation of metaphase plate congression;regulation of mitotic spindle organization","disordered domain specific binding;dynein complex binding;microtubule binding;microtubule minus-end binding;microtubule plus-end binding;phosphatidylinositol binding;protein complex binding;protein C-terminus binding;protein domain specific binding;structural molecule activity;tubulin binding","cell cortex;cell cortex region;centrosome;chromosome;cortical microtubule;cytoplasmic microtubule bundle;cytosol;dendrite;extracellular exosome;extrinsic component of plasma membrane;Golgi membrane;lateral cell cortex;lateral plasma membrane;microtubule bundle;microtubule minus-end;microtubule plus-end;mitotic spindle;mitotic spindle astral microtubule;mitotic spindle midzone;mitotic spindle pole;neuronal cell body;nuclear matrix;nucleoplasm;nucleus;protein complex;spindle;spindle microtubule;spindle pole;spindle pole centrosome",{"$nulls":3},7,7,7,"4.5","4.5","4.5","238.26",0,"70.86",159420000,21,"1.78051","0.360737","0.78995","7.67015","sp|Q14980|NUMA1_HUMAN;tr|A0A087WY61|A0A087WY61_HUMAN;tr|F5H6Y5|F5H6Y5_HUMAN;tr|F5H4J1|F5H4J1_HUMAN;tr|H0YFY6|H0YFY6_HUMAN;tr|K4DIE0|K4DIE0_HUMAN","sp|Q14980|NUMA1_HUMAN;tr|A0A087WY61|A0A087WY61_HUMAN",1651,"Q14980","NUMA1_HUMAN","Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}",null,"NUMA1"]
["24.2871","23.8521","23.801","22.7641",{"$nulls":3},"gluconeogenesis;malate metabolic process;NADH metabolic process;oxaloacetate metabolic process;tricarboxylic acid cycle","diiodophenylpyruvate reductase activity;L-malate dehydrogenase activity;malic enzyme activity;NAD binding","cytosol;extracellular exosome;extracellular space;mitochondrion;myelin sheath","Carbon metabolism;Citrate cycle (TCA cycle);Cysteine and methionine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Proximal tubule bicarbonate reclamation;Pyruvate metabolism",null,null,7,7,7,"26.9","26.9","26.9","36.426",0,"21.867",1891600000,42,"0.527973","0.498987","0.787059","1.39989","sp|P40925|MDHC_HUMAN;tr|B9A041|B9A041_HUMAN;tr|B8ZZ51|B8ZZ51_HUMAN;tr|C9JF79|C9JF79_HUMAN;tr|C9JRL4|C9JRL4_HUMAN;tr|C9JLV6|C9JLV6_HUMAN","sp|P40925|MDHC_HUMAN;tr|B9A041|B9A041_HUMAN;tr|B8ZZ51|B8ZZ51_HUMAN;tr|C9JF79|C9JF79_HUMAN",975,"P40925","MDHC_HUMAN","Malate dehydrogenase, cytoplasmic",null,"MDH1"]
["17.8892","17.5931","15.9333","17.9796",{"$nulls":3},"ciliary basal body-plasma membrane docking;cilium organization;G2/M transition of mitotic cell cycle;regulation of G2/M transition of mitotic cell cycle",null,"centriole;centrosome;ciliary basal body;cytosol",{"$nulls":3},2,2,2,"6.8","6.8","6.8","76.396",0,"8.6342",52407000,4,"0.278097","0.752602","0.784645","0.758991","sp|Q5JTW2|CEP78_HUMAN;tr|A8MST6|A8MST6_HUMAN","sp|Q5JTW2|CEP78_HUMAN;tr|A8MST6|A8MST6_HUMAN",1815,"Q5JTW2","CEP78_HUMAN","Centrosomal protein of 78 kDa","ep78","CEP78"]
["21.5713","21.3823","20.5091","20.8792",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;maturation of SSU-rRNA;mRNA splicing, via spliceosome;RNA splicing;tRNA processing","RNA binding","cytosol;extracellular exosome;nucleolus;nucleoplasm;P-body;small nuclear ribonucleoprotein complex;small nucleolar ribonucleoprotein complex;spliceosomal complex;U4/U6 x U5 tri-snRNP complex;U6 snRNP","RNA degradation;Spliceosome",null,null,2,2,2,"23.8","23.8","23.8","9.1275",0,"4.3454",87215000,7,"1.19508","0.326789","0.782613","3.76656","sp|P62312|LSM6_HUMAN","sp|P62312|LSM6_HUMAN",1303,"P62312","LSM6_HUMAN","U6 snRNA-associated Sm-like protein LSm6",null,"LSM6"]
["18.3617","18.5567","16.9284","18.4397",{"$nulls":4},"NAD+ kinase activity","intracellular membrane-bounded organelle;mitochondrion",{"$nulls":3},2,2,2,"11.9","11.9","11.9","43.796",0,"22.147",70431000,10,"0.380913","0.640474","0.775155","1.01744","tr|E9PC15|E9PC15_HUMAN;sp|Q53H12|AGK_HUMAN;tr|A0A0G2JLG5|A0A0G2JLG5_HUMAN;tr|E9PG39|E9PG39_HUMAN","tr|E9PC15|E9PC15_HUMAN;sp|Q53H12|AGK_HUMAN;tr|A0A0G2JLG5|A0A0G2JLG5_HUMAN;tr|E9PG39|E9PG39_HUMAN",1796,"E9PC15","E9PC15_HUMAN",null,null,"AGK"]
["17.6597","18.1728","16.9586","17.3366",{"$nulls":3},"microtubule-based movement","ATP binding;microtubule binding;microtubule motor activity",{"$nulls":4},1,1,1,"6.3","6.3","6.3","32.692",0,"14.451",17402000,1,"0.862146","0.301388","0.768669","2.41187","tr|D6R9M0|D6R9M0_HUMAN","tr|D6R9M0|D6R9M0_HUMAN",3079,"D6R9M0","D6R9M0_HUMAN",null,null,"KIF2A"]
["17.5884","17.9325","17.7209","16.269",{"$nulls":9},1,1,1,"7.2","7.2","7.2","17.608","0.001404","2.2826",9603700,1,"0.384333","0.635918","0.765539","1.02611","tr|Q5T8U9|Q5T8U9_HUMAN;sp|Q8N4J0|CARME_HUMAN","tr|Q5T8U9|Q5T8U9_HUMAN;sp|Q8N4J0|CARME_HUMAN",2050,"Q5T8U9","Q5T8U9_HUMAN",null,null,"CARNMT1"]
["17.5118","15.2643","15.691","15.5673",{"$nulls":3},"activation of GTPase activity;autophagy;intracellular protein transport;macroautophagy;positive regulation of receptor internalization;regulation of vesicle fusion;response to starvation;retrograde transport, endosome to Golgi","AP-2 adaptor complex binding;GTPase activator activity;Rab GTPase binding;retromer complex binding","autophagosome;cytosol;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;retromer complex",{"$nulls":3},3,3,3,"4.8","4.8","4.8","89.003",0,"3.7032",26378000,3,"0.24443","0.783896","0.758925","0.674332","sp|Q92609|TBCD5_HUMAN;tr|C9J3F6|C9J3F6_HUMAN","sp|Q92609|TBCD5_HUMAN;tr|C9J3F6|C9J3F6_HUMAN",2178,"Q92609","TBCD5_HUMAN","TBC1 domain family member 5",null,"TBC1D5"]
["21.272","21.4549","21.9039","19.3058",{"$nulls":3},"mRNA splicing, via spliceosome;nuclear import;RNA splicing;spliceosomal complex assembly;spliceosomal snRNP assembly","RNA binding","catalytic step 2 spliceosome;cytosol;extracellular exosome;methylosome;nucleoplasm;pICln-Sm protein complex;precatalytic spliceosome;small nuclear ribonucleoprotein complex;SMN-Sm protein complex;spliceosomal complex;U1 snRNP;U12-type spliceosomal complex;U2 snRNP;U4 snRNP;U4/U6 x U5 tri-snRNP complex;U5 snRNP","Spliceosome",null,null,3,3,3,"32.2","32.2","32.2","13.527",0,"4.4101",194760000,5,"0.208223","0.815343","0.758633","0.58255","sp|P62316|SMD2_HUMAN;tr|K7ERG4|K7ERG4_HUMAN;tr|K7EJB5|K7EJB5_HUMAN","sp|P62316|SMD2_HUMAN;tr|K7ERG4|K7ERG4_HUMAN",1305,"P62316","SMD2_HUMAN","Small nuclear ribonucleoprotein Sm D2","m-D2","SNRPD2"]
["17.6228","17.5338","17.9007","15.8097",{"$nulls":3},"beta-catenin destruction complex assembly;beta-catenin destruction complex disassembly;canonical Wnt signaling pathway;cellular response to amyloid-beta;cellular response to interleukin-3;chemical synaptic transmission, postsynaptic;circadian rhythm;dopamine receptor signaling pathway;epithelial to mesenchymal transition;ER overload response;extrinsic apoptotic signaling pathway in absence of ligand;glycogen metabolic process;hippocampus development;intracellular signal transduction;negative regulation of apoptotic process;negative regulation of canonical Wnt signaling pathway;negative regulation of dopaminergic neuron differentiation;negative regulation of glycogen (starch) synthase activity;negative regulation of glycogen biosynthetic process;negative regulation of neuron death;negative regulation of NFAT protein import into nucleus;negative regulation of protein binding;negative regulation of protein complex assembly;negative regulation of protein localization to nucleus;negative regulation of type B pancreatic cell development;neuron projection development;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of cell-matrix adhesion;positive regulation of gene expression;positive regulation of GTPase activity;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of mitochondrion organization;positive regulation of neuron death;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein binding;positive regulation of protein catabolic process;positive regulation of protein complex assembly;positive regulation of protein export from nucleus;positive regulation of protein localization to centrosome;proteasome-mediated ubiquitin-dependent protein catabolic process;protein autophosphorylation;protein phosphorylation;regulation of apoptotic process;regulation of cellular response to heat;regulation of microtubule cytoskeleton organization;regulation of microtubule-based process;superior temporal gyrus development;Wnt signaling pathway","ATP binding;beta-catenin binding;dynactin binding;kinase activity;NF-kappaB binding;p53 binding;protease binding;protein kinase A catalytic subunit binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;RNA polymerase II transcription factor binding;tau-protein kinase activity;ubiquitin protein ligase binding","beta-catenin destruction complex;centrosome;cytoplasm;cytosol;mitochondrion;nucleoplasm;nucleus;plasma membrane;postsynapse;Wnt signalosome","Alzheimer disease;Axon guidance;B cell receptor signaling pathway;Basal cell carcinoma;Breast cancer;Cell cycle;Chemokine signaling pathway;Colorectal cancer;Cushing syndrome;Dopaminergic synapse;EGFR tyrosine kinase inhibitor resistance;Endometrial cancer;ErbB signaling pathway;Focal adhesion;Gastric cancer;Hedgehog signaling pathway;Hepatitis C;Hepatocellular carcinoma;Hippo signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;IL-17 signaling pathway;Insulin resistance;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Measles;Melanogenesis;mTOR signaling pathway;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Pathways in cancer;PI3K-Akt signaling pathway;Prolactin signaling pathway;Prostate cancer;Signaling pathways regulating pluripotency of stem cells;T cell receptor signaling pathway;Thyroid hormone signaling pathway;Wnt signaling pathway;Yersinia infection",null,null,2,2,2,11,11,11,"46.744",0,"4.5688",38768000,7,"0.251041","0.772118","0.723084","0.690992","sp|P49841|GSK3B_HUMAN","sp|P49841|GSK3B_HUMAN",1101,"P49841","GSK3B_HUMAN","Glycogen synthase kinase-3 beta","SK-3 beta","GSK3B"]
["19.1534","18.8392","18.5376","18.047",{"$nulls":9},1,1,1,"16.2","16.2","16.2","9.116",0,"8.8603",13830000,5,"0.863599","0.300842","0.704003","2.41689","tr|K7ELP6|K7ELP6_HUMAN;sp|Q53F19|NCBP3_HUMAN","tr|K7ELP6|K7ELP6_HUMAN;sp|Q53F19|NCBP3_HUMAN",1792,"K7ELP6","K7ELP6_HUMAN",null,null,"NCBP3"]
["19.9951","20.1494","19.4391","19.3235",{"$nulls":3},"B cell activation;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of stress-activated MAPK cascade;negative regulation of transcription from RNA polymerase II promoter;regulation of dephosphorylation;regulation of microtubule-based movement;response to interleukin-1;response to tumor necrosis factor;signal transduction","protein phosphatase 2A binding;protein phosphatase regulator activity","cytoplasm;cytosol","Autophagy - animal;Autophagy - other",null,null,3,3,3,"15.3","15.3","15.3","39.221",0,"79.86",125320000,26,"1.72295","0.348543","0.690907","7.16541","sp|P78318|IGBP1_HUMAN","sp|P78318|IGBP1_HUMAN",1364,"P78318","IGBP1_HUMAN","Immunoglobulin-binding protein 1",null,"IGBP1"]
["18.697","19.0738","18.3789","18.0192",{"$nulls":9},8,8,8,16,16,16,"84.69",0,"22.335",104460000,23,"0.9249","0.29502","0.686376","2.63507","tr|H3BQZ7|H3BQZ7_HUMAN;sp|Q1KMD3|HNRL2_HUMAN","tr|H3BQZ7|H3BQZ7_HUMAN;sp|Q1KMD3|HNRL2_HUMAN",1764,"H3BQZ7","H3BQZ7_HUMAN",null,null,"HNRNPUL2-BSCL2"]
["19.148","18.7981","18.145","18.4431",{"$nulls":3},"coenzyme A biosynthetic process;coenzyme biosynthetic process","ATP binding;dephospho-CoA kinase activity;pantetheine-phosphate adenylyltransferase activity","extracellular exosome;mitochondrial matrix;mitochondrial outer membrane","Metabolic pathways;Pantothenate and CoA biosynthesis",null,null,4,4,4,"12.1","12.1","12.1","62.328",0,"16.536",97857000,13,"1.0086","0.294967","0.678946","2.95396","sp|Q13057|COASY_HUMAN;tr|K7ES73|K7ES73_HUMAN;tr|K7EN91|K7EN91_HUMAN;tr|K7EP09|K7EP09_HUMAN;tr|K7EPT0|K7EPT0_HUMAN;tr|K7ESK6|K7ESK6_HUMAN","sp|Q13057|COASY_HUMAN;tr|K7ES73|K7ES73_HUMAN;tr|K7EN91|K7EN91_HUMAN",1516,"Q13057","COASY_HUMAN","Bifunctional coenzyme A synthase","oA synthase","COASY"]
["17.4851","17.4647","17.0918","16.5094",{"$nulls":3},"nucleobase-containing compound metabolic process;nucleotide biosynthetic process","enzyme inhibitor activity;identical protein binding;magnesium ion binding;ribose phosphate diphosphokinase activity",{"$nulls":4},2,2,2,"7.3","7.3","7.3","39.393",0,"8.8295",42193000,13,"0.833544","0.313162","0.67432","2.31426","sp|Q14558|KPRA_HUMAN;tr|C9JKT9|C9JKT9_HUMAN;tr|C9JNQ3|C9JNQ3_HUMAN;tr|C9JUN4|C9JUN4_HUMAN;tr|C9J168|C9J168_HUMAN;tr|B4DP31|B4DP31_HUMAN","sp|Q14558|KPRA_HUMAN;tr|C9JKT9|C9JKT9_HUMAN;tr|C9JNQ3|C9JNQ3_HUMAN;tr|C9JUN4|C9JUN4_HUMAN;tr|C9J168|C9J168_HUMAN;tr|B4DP31|B4DP31_HUMAN",1628,"Q14558","KPRA_HUMAN","Phosphoribosyl pyrophosphate synthase-associated protein 1","RPP synthase-associated protein 1","PRPSAP1"]
["19.2119","19.7559","17.9238","19.7018",{"$nulls":3},"mRNA methylation;tRNA methylation;tRNA modification","RNA binding","nucleoplasm;tRNA (m1A) methyltransferase complex",{"$nulls":3},5,5,5,"16.5","16.5","16.5","55.799",0,"65.743",195820000,24,"0.263338","0.758955","0.671165","0.721931","sp|Q9UJA5|TRM6_HUMAN","sp|Q9UJA5|TRM6_HUMAN",2855,"Q9UJA5","TRM6_HUMAN","tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6",null,"TRMT6"]
["17.79","17.7398","16.8219","17.3715",{"$nulls":3},"pyrimidine nucleotide metabolic process","dCMP deaminase activity;zinc ion binding",{"$nulls":4},2,2,2,16,16,16,"18.977",0,"3.4958",21222000,4,"0.864915","0.302591","0.668203","2.42145","tr|D6RBJ9|D6RBJ9_HUMAN;sp|P32321|DCTD_HUMAN;tr|D6RAD7|D6RAD7_HUMAN;tr|D6RAR9|D6RAR9_HUMAN;tr|D6RC36|D6RC36_HUMAN;tr|D6R9S0|D6R9S0_HUMAN;tr|D6RBN2|D6RBN2_HUMAN","tr|D6RBJ9|D6RBJ9_HUMAN;sp|P32321|DCTD_HUMAN;tr|D6RAD7|D6RAD7_HUMAN;tr|D6RAR9|D6RAR9_HUMAN;tr|D6RC36|D6RC36_HUMAN;tr|D6R9S0|D6R9S0_HUMAN;tr|D6RBN2|D6RBN2_HUMAN",903,"D6RBJ9","D6RBJ9_HUMAN",null,null,"DCTD"]
["17.9954","18.4753","18.2398","16.9042",{"$nulls":4},"ATP binding;nucleic acid binding",{"$nulls":4},7,7,7,"14.5","14.5","14.5","91.48",0,"33.728",85578000,19,"0.348165","0.687378","0.663342","0.9348","tr|G3V529|G3V529_HUMAN;sp|Q9GZR7|DDX24_HUMAN;tr|F5GYL3|F5GYL3_HUMAN;tr|A0A087WXU8|A0A087WXU8_HUMAN","tr|G3V529|G3V529_HUMAN;sp|Q9GZR7|DDX24_HUMAN;tr|F5GYL3|F5GYL3_HUMAN",2539,"G3V529","G3V529_HUMAN",null,null,"DDX24"]
["18.6882","18.5892","18.3161","17.6364",{"$nulls":4},"nucleic acid binding",{"$nulls":4},2,2,2,"8.9","8.9","8.9","59.57",0,"25.163",56636000,5,"0.713252","0.360035","0.66243","1.92892","tr|A0A0A6YYC7|A0A0A6YYC7_HUMAN;sp|Q96JP5|ZFP91_HUMAN","tr|A0A0A6YYC7|A0A0A6YYC7_HUMAN;sp|Q96JP5|ZFP91_HUMAN",2309,"A0A0A6YYC7","A0A0A6YYC7_HUMAN",null,null,"ZFP91-CNTF"]
["23.4385","23.499","22.8064","22.8111",{"$nulls":3},"histone H3-K27 trimethylation;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;nucleosome assembly;nucleosome positioning","ADP binding;AMP binding;ATP binding;calcium ion binding;chromatin DNA binding;dATP binding;double-stranded DNA binding;GTP binding;RNA binding","extracellular exosome;nuclear heterochromatin;nuclear nucleosome;nucleus",{"$nulls":3},3,3,3,"17.8","17.8","17.8","21.865",0,"8.0616",456240000,15,"2.67607","0.588429","0.659944","21.7445","sp|P10412|H14_HUMAN;sp|P16403|H12_HUMAN;sp|P16402|H13_HUMAN;sp|P22492|H1T_HUMAN;sp|Q02539|H11_HUMAN","sp|P10412|H14_HUMAN;sp|P16403|H12_HUMAN;sp|P16402|H13_HUMAN",606,"P10412","H14_HUMAN","Histone H1.4",null,"HIST1H1E"]
["19.8128","19.7645","18.8768","19.3809",{"$nulls":3},"blood coagulation;early endosome to late endosome transport;endocytosis;membrane organization;phagocytosis;phosphatidylinositol biosynthetic process;positive regulation of exocytosis;post-translational protein modification;protein transport;receptor internalization involved in canonical Wnt signaling pathway;regulation of autophagosome assembly;regulation of endocytosis;regulation of endosome size;regulation of filopodium assembly;regulation of synaptic vesicle exocytosis;synaptic vesicle recycling;transcytosis;viral RNA genome replication","GDP binding;GTP binding;GTPase activity","actin cytoskeleton;axon;axon terminus;clathrin-coated vesicle membrane;cytoplasm;cytoplasmic side of early endosome membrane;cytosol;dendrite;early endosome;early endosome membrane;endocytic vesicle;endosome;endosome membrane;extracellular exosome;melanosome;membrane raft;neuronal cell body;phagocytic vesicle membrane;plasma membrane;ruffle;somatodendritic compartment;synaptic vesicle;terminal bouton","Amoebiasis;Amyotrophic lateral sclerosis (ALS);Endocytosis;Phagosome;Ras signaling pathway;Tuberculosis;Vasopressin-regulated water reabsorption",null,null,5,4,4,"38.6","33.5","33.5","23.658",0,"17.598",69144000,6,"0.91694","0.293569","0.659842","2.60604","sp|P20339|RAB5A_HUMAN","sp|P20339|RAB5A_HUMAN",741,"P20339","RAB5A_HUMAN","Ras-related protein Rab-5A",null,"RAB5A"]
["21.0793","20.6478","20.4681","19.9536",{"$nulls":4},"RNA binding",{"$nulls":4},1,1,1,"11.5","11.5","11.5","10.083","0.00076278","2.9368",74462000,1,"0.718199","0.356639","0.652672","1.94403","tr|M0R0G9|M0R0G9_HUMAN;tr|M0QXK2|M0QXK2_HUMAN;tr|M0R221|M0R221_HUMAN;tr|M0R2B8|M0R2B8_HUMAN;tr|M0QZG7|M0QZG7_HUMAN;sp|P09012|SNRPA_HUMAN","tr|M0R0G9|M0R0G9_HUMAN;tr|M0QXK2|M0QXK2_HUMAN;tr|M0R221|M0R221_HUMAN;tr|M0R2B8|M0R2B8_HUMAN;tr|M0QZG7|M0QZG7_HUMAN;sp|P09012|SNRPA_HUMAN",576,"M0R0G9","M0R0G9_HUMAN",null,null,"SNRPA"]
["18.2327","17.9245","17.5412","17.3173",{"$nulls":3},"male meiosis I;male meiotic nuclear division;negative regulation of inclusion body assembly;positive regulation of calcium-transporting ATPase activity;positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle;protein refolding;response to cold;response to heat;response to unfolded protein;spermatid development;spermatogenesis;synaptonemal complex disassembly","ATP binding;disordered domain specific binding;enzyme binding;glycolipid binding;unfolded protein binding","blood microparticle;CatSper complex;cell surface;cytosol;extracellular exosome;male germ cell nucleus;meiotic spindle;membrane;mitochondrion;myelin sheath;nucleus;synaptonemal complex","Antigen processing and presentation;Endocytosis;Estrogen signaling pathway;Legionellosis;Longevity regulating pathway - multiple species;MAPK signaling pathway;Measles;Protein processing in endoplasmic reticulum;Spliceosome;Toxoplasmosis",null,null,14,5,4,"22.5","9.4","8.1","70.02",0,"38.505",97498000,22,"1.11713","0.30842","0.649332","3.40815","sp|P54652|HSP72_HUMAN","sp|P54652|HSP72_HUMAN",1193,"P54652","HSP72_HUMAN","Heat shock-related 70 kDa protein 2","eat shock 70 kDa protein 2","HSPA2"]
["19.2254","19.4969","18.7162","18.7119",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell cycle;cell division;clathrin coat assembly;clathrin-dependent endocytosis;intracellular protein transport;low-density lipoprotein particle clearance;low-density lipoprotein particle receptor catabolic process;membrane organization;microtubule-based movement","clathrin heavy chain binding;GTPase binding;peptide binding;protein complex binding;structural molecule activity","clathrin coat;clathrin coat of coated pit;clathrin coat of trans-Golgi network vesicle;clathrin complex;clathrin vesicle coat;clathrin-coated endocytic vesicle;cytoplasmic vesicle;cytosol;endolysosome membrane;membrane;plasma membrane;spindle;synaptic vesicle membrane;trans-Golgi network membrane","Bacterial invasion of epithelial cells;Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Huntington disease;Lysosome;Synaptic vesicle cycle",null,null,1,1,1,"3.6","3.6","3.6","27.076","0.0075583","1.7509",23686000,3,"1.38382","0.334937","0.647116","4.76559","sp|P09496|CLCA_HUMAN;tr|F8WF69|F8WF69_HUMAN","sp|P09496|CLCA_HUMAN;tr|F8WF69|F8WF69_HUMAN",585,"P09496","CLCA_HUMAN","Clathrin light chain A","ca","CLTA"]
["17.4799","16.9208","17.3338","15.8084",{"$nulls":3},"intra-Golgi vesicle-mediated transport;mitotic cell cycle;regulation of centrosome duplication;response to drug;retrograde transport, endosome to Golgi;retrograde vesicle-mediated transport, Golgi to ER;small GTPase mediated signal transduction","GTP binding;GTPase activity","centrosome;cytosol;Golgi apparatus;intracellular;nucleus",{"$nulls":3},1,1,1,"8.7","8.7","8.7","28.355",0,"30.82",8576600,2,"0.284348","0.745524","0.629274","0.774672","sp|Q9H0N0|RAB6C_HUMAN","sp|Q9H0N0|RAB6C_HUMAN",2560,"Q9H0N0","RAB6C_HUMAN","Ras-related protein Rab-6C",null,"RAB6C"]
["16.2941","15.8533","14.9114","15.9875",{"$nulls":3},"transport","ATP binding;ATPase activity, coupled to transmembrane movement of substances;transporter activity","ATP-binding cassette (ABC) transporter complex;membrane;mitochondrial envelope;mitochondrial inner membrane;mitochondrion;nucleolus;nucleus","ABC transporters",null,null,2,2,2,"3.4","3.4","3.4","79.988",0,"3.5921",28186000,2,"0.403054","0.618585","0.624235","1.07368","sp|Q9NUT2|ABCB8_HUMAN","sp|Q9NUT2|ABCB8_HUMAN",2711,"Q9NUT2","ABCB8_HUMAN","ATP-binding cassette sub-family B member 8, mitochondrial",null,"ABCB8"]
["16.221","16.2575","15.866","15.3683",{"$nulls":3},"anterior semicircular canal development;anterior/posterior pattern specification;artery development;axon guidance;branching involved in ureteric bud morphogenesis;camera-type eye morphogenesis;cell differentiation involved in kidney development;developmental growth;embryonic digestive tract development;embryonic digestive tract morphogenesis;embryonic digit morphogenesis;embryonic skeletal system morphogenesis;forebrain dorsal/ventral pattern formation;forebrain radial glial cell differentiation;frontal suture morphogenesis;heart development;hindgut morphogenesis;hippocampus development;in utero embryonic development;lambdoid suture morphogenesis;lateral ganglionic eminence cell proliferation;lateral semicircular canal development;layer formation in cerebral cortex;limb morphogenesis;liver regeneration;lung development;mammary gland specification;melanocyte differentiation;metanephros development;negative regulation of alpha-beta T cell differentiation;negative regulation of apoptotic process;negative regulation of canonical Wnt signaling pathway;negative regulation of cell proliferation;negative regulation of neuron differentiation;negative regulation of smoothened signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative thymic T cell selection;nose morphogenesis;odontogenesis of dentin-containing tooth;oligodendrocyte differentiation;optic nerve morphogenesis;palate development;positive regulation of alpha-beta T cell differentiation;positive regulation of chondrocyte differentiation;positive regulation of neuroblast proliferation;positive regulation of osteoblast differentiation;positive regulation of protein import into nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;prostate gland development;protein processing;proximal/distal pattern formation;regulation of bone development;response to estrogen;sagittal suture morphogenesis;smoothened signaling pathway;smoothened signaling pathway involved in dorsal/ventral neural tube patterning;smoothened signaling pathway involved in spinal cord motor neuron cell fate specification;smoothened signaling pathway involved in ventral spinal cord interneuron specification;T cell differentiation in thymus;thymocyte apoptotic process;tongue development;wound healing","beta-catenin binding;chromatin binding;DNA binding transcription factor activity;histone acetyltransferase binding;histone deacetylase binding;metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","axoneme;ciliary base;ciliary tip;cilium;cytoplasm;cytosol;nuclear speck;nucleoplasm;nucleus;transcriptional repressor complex","Basal cell carcinoma;cAMP signaling pathway;Hedgehog signaling pathway;Pathways in cancer",null,null,2,2,2,"2.1","2.1","2.1","169.86",0,"42.908",25110000,10,"0.885355","0.300747","0.62213","2.49293","sp|P10071|GLI3_HUMAN;tr|C9J9N4|C9J9N4_HUMAN","sp|P10071|GLI3_HUMAN;tr|C9J9N4|C9J9N4_HUMAN",603,"P10071","GLI3_HUMAN","Transcriptional activator GLI3",null,"GLI3"]
["14.991","14.7551","15.4754","13.04",{"$nulls":4},"potassium:chloride symporter activity","integral component of membrane",{"$nulls":3},1,1,1,"1.7","1.7","1.7","115.05",0,"5.7149",15337000,5,"0.177246","0.843075","0.615362","0.502991","tr|I3L4N6|I3L4N6_HUMAN;sp|Q9UP95|S12A4_HUMAN","tr|I3L4N6|I3L4N6_HUMAN;sp|Q9UP95|S12A4_HUMAN",2919,"I3L4N6","I3L4N6_HUMAN",null,null,"SLC12A4"]
["17.0904","16.3796","16.0247","16.2187",{"$nulls":3},"cell migration;cell-cell adhesion;cytoskeleton organization",null,"cytosol",{"$nulls":3},3,3,3,"7.4","7.4","7.4","82.364",0,"5.8521",44579000,10,"0.623732","0.422131","0.613354","1.66498","tr|Q5JVZ5|Q5JVZ5_HUMAN;sp|Q96JJ3|ELMO2_HUMAN;tr|Q5JVZ8|Q5JVZ8_HUMAN;tr|H0YCM7|H0YCM7_HUMAN;tr|Q5JW01|Q5JW01_HUMAN;tr|Q5JVZ4|Q5JVZ4_HUMAN","tr|Q5JVZ5|Q5JVZ5_HUMAN;sp|Q96JJ3|ELMO2_HUMAN;tr|Q5JVZ8|Q5JVZ8_HUMAN;tr|H0YCM7|H0YCM7_HUMAN",2307,"Q5JVZ5","Q5JVZ5_HUMAN",null,null,"ELMO2"]
["16.6122","18.6276","16.2876","17.7289",{"$nulls":3},"cellular amino acid metabolic process;xenobiotic metabolic process","aminoacylase activity;identical protein binding;metal ion binding;metallopeptidase activity","cytosol;extracellular exosome","2-Oxocarboxylic acid metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Metabolic pathways",null,null,3,3,3,"10.5","10.5","10.5","45.884",0,"35.699",56059000,4,"0.173681","0.848214","0.611682","0.493751","sp|Q03154|ACY1_HUMAN;tr|C9JMV9|C9JMV9_HUMAN;tr|C9JYZ0|C9JYZ0_HUMAN;tr|F8WC59|F8WC59_HUMAN","sp|Q03154|ACY1_HUMAN;tr|C9JMV9|C9JMV9_HUMAN;tr|C9JYZ0|C9JYZ0_HUMAN",1437,"Q03154","ACY1_HUMAN","Aminoacylase-1","CY-1","ACY1"]
["18.039","17.3784","19.0127","15.1901",{"$nulls":5},"COP9 signalosome;nucleoplasm",{"$nulls":3},2,2,2,13,13,13,"26.424",0,"5.3885",27827000,3,"0.105782","0.912771","0.607347","0.313124","tr|J3KQ34|J3KQ34_HUMAN;sp|Q9H9Q2|CSN7B_HUMAN;tr|J3QT73|J3QT73_HUMAN;tr|A0A087X1P5|A0A087X1P5_HUMAN;tr|J3KQ41|J3KQ41_HUMAN","tr|J3KQ34|J3KQ34_HUMAN;sp|Q9H9Q2|CSN7B_HUMAN;tr|J3QT73|J3QT73_HUMAN;tr|A0A087X1P5|A0A087X1P5_HUMAN;tr|J3KQ41|J3KQ41_HUMAN",2626,"J3KQ34","J3KQ34_HUMAN",null,null,"COPS7B"]
["20.1678","20.1182","20.0523","19.0311",{"$nulls":9},4,4,4,13,13,13,"39.452",0,"39.343",186870000,15,"0.443022","0.561407","0.601285","1.17619","tr|A0A087X0K1|A0A087X0K1_HUMAN;sp|Q9Y376|CAB39_HUMAN","tr|A0A087X0K1|A0A087X0K1_HUMAN;sp|Q9Y376|CAB39_HUMAN",2974,"A0A087X0K1","A0A087X0K1_HUMAN",null,null,"CAB39"]
["16.4192","16.0859","16.6698","14.6355",{"$nulls":9},1,1,1,"5.3","5.3","5.3","34.458","0.0011017","2.645",8844400,2,"0.208021","0.815718","0.599905","0.582036","tr|A0A087WWZ2|A0A087WWZ2_HUMAN;sp|Q9H4Z3|PCIF1_HUMAN","tr|A0A087WWZ2|A0A087WWZ2_HUMAN;sp|Q9H4Z3|PCIF1_HUMAN",2601,"A0A087WWZ2","A0A087WWZ2_HUMAN",null,null,"PCIF1"]
["21.5063","21.4881","21.0828","20.7235",{"$nulls":3},"arginine biosynthetic process;argininosuccinate metabolic process;aspartate metabolic process;cellular response to laminar fluid shear stress;circadian rhythm;citrulline metabolic process;negative regulation of leukocyte cell-cell adhesion;positive regulation of nitric oxide biosynthetic process;urea cycle","amino acid binding;argininosuccinate synthase activity;ATP binding;identical protein binding;RNA binding","cytoplasm;cytosol;extracellular exosome;mitochondrion;myelin sheath","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Fluid shear stress and atherosclerosis;Metabolic pathways",null,null,10,10,10,"26.7","26.7","26.7","46.53",0,"41.285",553990000,41,"1.09277","0.310302","0.59401","3.3019","sp|P00966|ASSY_HUMAN;tr|Q5T6L5|Q5T6L5_HUMAN;tr|Q5T6L6|Q5T6L6_HUMAN","sp|P00966|ASSY_HUMAN",476,"P00966","ASSY_HUMAN","Argininosuccinate synthase {ECO:0000305}",null,"ASS1"]
["16.9738","17.7392","18.3491","15.1886",{"$nulls":3},"protein folding;response to stress","ATP binding;unfolded protein binding","cytoplasm",{"$nulls":3},6,1,1,"8.9","2.2","2.2","58.264","0.0097339","1.6715",44518000,2,"0.123548","0.901904","0.587612","0.361403","sp|Q58FF6|H90B4_HUMAN","sp|Q58FF6|H90B4_HUMAN",1800,"Q58FF6","H90B4_HUMAN","Putative heat shock protein HSP 90-beta 4",null,"HSP90AB4P"]
["21.2603","21.3238","20.5072","20.9101",{"$nulls":3},"Ras protein signal transduction","GTP binding;GTPase activity","intracellular;plasma membrane",{"$nulls":3},3,3,2,"23.2","23.2","16.5","18.26",0,"5.0201",111380000,5,"0.984739","0.297361","0.583411","2.86042","tr|H7C3P7|H7C3P7_HUMAN;sp|P11233|RALA_HUMAN;tr|F8WEQ6|F8WEQ6_HUMAN;tr|C9JPE8|C9JPE8_HUMAN;tr|C9JYR1|C9JYR1_HUMAN;tr|C9JQB3|C9JQB3_HUMAN","tr|H7C3P7|H7C3P7_HUMAN;sp|P11233|RALA_HUMAN",624,"H7C3P7","H7C3P7_HUMAN",null,null,"RALA"]
["18.2493","18.4403","18.1851","17.3485",{"$nulls":3},"mRNA processing","RNA binding","nucleus",{"$nulls":3},2,2,2,"5.9","5.9","5.9","56.45",0,"5.6513",56207000,5,"0.508218","0.514614","0.57802","1.34704","tr|B7WPG3|B7WPG3_HUMAN;tr|C9IYN3|C9IYN3_HUMAN;tr|D6W592|D6W592_HUMAN;sp|Q8WVV9|HNRLL_HUMAN;tr|C9JJZ7|C9JJZ7_HUMAN;tr|H7BXH8|H7BXH8_HUMAN","tr|B7WPG3|B7WPG3_HUMAN;tr|C9IYN3|C9IYN3_HUMAN;tr|D6W592|D6W592_HUMAN;sp|Q8WVV9|HNRLL_HUMAN;tr|C9JJZ7|C9JJZ7_HUMAN;tr|H7BXH8|H7BXH8_HUMAN",2146,"B7WPG3","B7WPG3_HUMAN",null,null,"HNRNPLL"]
["16.9267","16.7766","14.5459","18.0061",{"$nulls":3},"cell cycle","GTPase activator activity",{"$nulls":4},2,2,2,"4.8","4.8","4.8","64.999",0,"4.0183",26498000,2,"0.112846","0.904916","0.57566","0.332425","tr|A0A0C4DG54|A0A0C4DG54_HUMAN;sp|Q5R372|RBG1L_HUMAN","tr|A0A0C4DG54|A0A0C4DG54_HUMAN;sp|Q5R372|RBG1L_HUMAN",1820,"A0A0C4DG54","A0A0C4DG54_HUMAN",null,null,"RABGAP1L"]
["17.8371","18.7873","18.1986","17.2898",{"$nulls":4},"calcium ion binding",{"$nulls":4},2,2,2,"18.5","18.5","18.5","24.796",0,"6.7797",31766000,13,"0.319942","0.709144","0.567978","0.863914","tr|A8MXP8|A8MXP8_HUMAN;sp|Q14257|RCN2_HUMAN","tr|A8MXP8|A8MXP8_HUMAN;sp|Q14257|RCN2_HUMAN",1616,"A8MXP8","A8MXP8_HUMAN",null,null,"RCN2"]
["17.4124","18.628","18.225","16.6828",{"$nulls":3},"chaperone-mediated protein folding;'de novo' protein folding;plus-end-directed vesicle transport along microtubule;positive regulation of autophagosome maturation","ATP binding;metal ion binding;protein binding involved in protein folding;unfolded protein binding","autophagosome;Golgi apparatus;intracellular membrane-bounded organelle;late endosome;lysosome;membrane",{"$nulls":3},8,8,8,"7.8","7.8","7.8","166.98",0,"65.52",165770000,22,"0.205953","0.81768","0.566305","0.57676","sp|Q9BQS8|FYCO1_HUMAN","sp|Q9BQS8|FYCO1_HUMAN",2422,"Q9BQS8","FYCO1_HUMAN","FYVE and coiled-coil domain-containing protein 1",null,"FYCO1"]
["16.325","16.4632","16.0646","15.5973",{"$nulls":3},"apoptotic process;defense response to virus;inflammatory response;innate immune response;negative regulation of alpha-beta T cell proliferation;negative regulation of apoptotic process;negative regulation of defense response to virus;negative regulation of JNK cascade;negative regulation of NF-kappaB transcription factor activity;negative regulation of type I interferon production;Notch signaling pathway;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of protein catabolic process;positive regulation of receptor catabolic process;positive regulation of T cell anergy;proteasome-mediated ubiquitin-dependent protein catabolic process;protein autoubiquitination;protein K29-linked ubiquitination;protein K48-linked ubiquitination;protein K63-linked ubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of cell growth;regulation of hematopoietic stem cell differentiation;regulation of protein deubiquitination;ubiquitin-dependent protein catabolic process;viral entry into host cell","arrestin family protein binding;CXCR chemokine receptor binding;ligase activity;ribonucleoprotein complex binding;ubiquitin protein ligase activity;ubiquitin-like protein ligase binding;ubiquitin-like protein transferase activity;ubiquitin-protein transferase activity","cell cortex;cytoplasm;cytosol;early endosome membrane;extracellular exosome;membrane;nucleoplasm;plasma membrane;protein complex","Endocytosis;Non-alcoholic fatty liver disease (NAFLD);TNF signaling pathway;Ubiquitin mediated proteolysis",null,null,2,2,2,"3.8","3.8","3.8","102.8",0,"32.942",39119000,8,"0.832658","0.314674","0.563168","2.31128","sp|Q96J02|ITCH_HUMAN","sp|Q96J02|ITCH_HUMAN",2302,"Q96J02","ITCH_HUMAN","E3 ubiquitin-protein ligase Itchy homolog","tch","ITCH"]
["19.5978","19.2932","19.9011","17.8716",{"$nulls":3},"dolichol metabolic process;GPI anchor biosynthetic process;protein mannosylation;protein N-linked glycosylation via asparagine;protein O-linked mannosylation","dolichyl-phosphate beta-D-mannosyltransferase activity;dolichyl-phosphate-mannose-protein mannosyltransferase activity","dolichol-phosphate-mannose synthase complex;endoplasmic reticulum;endoplasmic reticulum membrane;membrane;nucleus","Metabolic pathways;N-Glycan biosynthesis",null,null,3,3,3,"18.8","18.8","18.8","29.634",0,"6.0781",92916000,12,"0.193526","0.828248","0.559177","0.54495","sp|O60762|DPM1_HUMAN;tr|Q5QPK2|Q5QPK2_HUMAN;tr|H0Y368|H0Y368_HUMAN;tr|Q5QPJ9|Q5QPJ9_HUMAN","sp|O60762|DPM1_HUMAN;tr|Q5QPK2|Q5QPK2_HUMAN;tr|H0Y368|H0Y368_HUMAN",303,"O60762","DPM1_HUMAN","Dolichol-phosphate mannosyltransferase subunit 1",null,"DPM1"]
["16.6873","13.5999","15.1475","14.0339",{"$nulls":3},"autophagy;cell proliferation;maintenance of unfolded protein involved in ERAD pathway;melanocyte differentiation;positive regulation of ERAD pathway;protein deubiquitination;protein K29-linked deubiquitination;protein K63-linked deubiquitination;protein K6-linked deubiquitination;protein stabilization;regulation of autophagy;regulation of transcription, DNA-templated;ubiquitin-dependent protein catabolic process","BAT3 complex binding;chaperone binding;cysteine-type endopeptidase activity;proteasome binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitin binding;ubiquitin protein ligase binding;ubiquitin-like protein ligase binding;ubiquitin-specific protease activity involved in positive regulation of ERAD pathway;zinc ion binding","cytosol;nucleoplasm",{"$nulls":3},2,2,2,"4.6","4.6","4.6","97.326","0.0010688","2.3842",18187000,5,"0.114498","0.903497","0.552892","0.336918","sp|Q92995|UBP13_HUMAN;tr|H7C5J3|H7C5J3_HUMAN","sp|Q92995|UBP13_HUMAN;tr|H7C5J3|H7C5J3_HUMAN",2211,"Q92995","UBP13_HUMAN","Ubiquitin carboxyl-terminal hydrolase 13",null,"USP13"]
["21.5351","21.0385","21.3035","20.1677",{"$nulls":9},3,3,3,"30.9","30.9","30.9","20.987",0,"18.975",175270000,16,"0.330059","0.702407","0.551199","0.889301","tr|E9PPQ1|E9PPQ1_HUMAN;sp|Q16890|TPD53_HUMAN;tr|J3KNE7|J3KNE7_HUMAN;tr|E9PNK6|E9PNK6_HUMAN;tr|E9PNQ9|E9PNQ9_HUMAN","tr|E9PPQ1|E9PPQ1_HUMAN;sp|Q16890|TPD53_HUMAN;tr|J3KNE7|J3KNE7_HUMAN;tr|E9PNK6|E9PNK6_HUMAN",1762,"E9PPQ1","E9PPQ1_HUMAN",null,null,"TPD52L1"]
["19.3085","19.0214","19.7368","17.492",{"$nulls":3},"calcium ion transmembrane transport;positive regulation of axon extension;positive regulation of calcium ion import;response to heat;response to temperature stimulus;sensory perception;transport","calcium channel activity;cation channel activity;ion channel activity;ion transmembrane transporter activity","axonal growth cone;cell body;cell surface;growth cone membrane;integral component of plasma membrane;melanosome;plasma membrane","Inflammatory mediator regulation of TRP channels;NOD-like receptor signaling pathway",null,null,4,4,4,6,6,6,"85.98",0,"63.7",181310000,19,"0.17091","0.850698","0.550554","0.486559","sp|Q9Y5S1|TRPV2_HUMAN;tr|H7BZK2|H7BZK2_HUMAN","sp|Q9Y5S1|TRPV2_HUMAN",3025,"Q9Y5S1","TRPV2_HUMAN","Transient receptor potential cation channel subfamily V member 2","rpV2","TRPV2"]
["19.6313","19.2167","18.9194","18.8316",{"$nulls":3},"transposition, RNA-mediated","identical protein binding;nucleotide binding;single-stranded DNA binding;single-stranded RNA binding","cytoplasm;cytoplasmic stress granule;intracellular ribonucleoprotein complex;nucleolus",{"$nulls":3},3,3,3,"11.2","11.2","11.2","40.055",0,"6.1399",74045000,7,"0.912087","0.293439","0.548512","2.58845","sp|Q9UN81|LORF1_HUMAN","sp|Q9UN81|LORF1_HUMAN",2905,"Q9UN81","LORF1_HUMAN","LINE-1 retrotransposable element ORF1 protein","1ORF1p","L1RE1"]
["17.1961","18.9947","17.7433","17.3521",{"$nulls":3},"cellular nitrogen compound metabolic process;mitochondrial acetyl-CoA biosynthetic process from pyruvate;pyruvate metabolic process;regulation of acetyl-CoA biosynthetic process from pyruvate","transferase activity, transferring acyl groups","mitochondrial matrix;pyruvate dehydrogenase complex","Metabolic pathways",null,null,2,2,2,"8.8","8.8","8.8","54.122",0,"5.0477",48144000,10,"0.213176","0.808952","0.547726","0.59517","sp|O00330|ODPX_HUMAN;tr|E9PLU0|E9PLU0_HUMAN;tr|E9PRI6|E9PRI6_HUMAN","sp|O00330|ODPX_HUMAN;tr|E9PLU0|E9PLU0_HUMAN;tr|E9PRI6|E9PRI6_HUMAN",136,"O00330","ODPX_HUMAN","Pyruvate dehydrogenase protein X component, mitochondrial",null,"PDHX"]
["16.3631","15.8982","15.823","15.3506",{"$nulls":3},"negative regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of translation;response to endoplasmic reticulum stress",null,"cytoplasm;cytosol;extracellular exosome;membrane;plasma membrane",{"$nulls":3},2,2,2,"2.6","2.6","2.6","103.13",0,"7.4112",32911000,6,"0.615286","0.424373","0.543853","1.64094","sp|Q9BZQ8|NIBAN_HUMAN","sp|Q9BZQ8|NIBAN_HUMAN",2524,"Q9BZQ8","NIBAN_HUMAN","Protein Niban",null,"FAM129A"]
["21.6902","21.7163","21.8597","20.4699",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;regulation of alternative mRNA splicing, via spliceosome;regulation of translation;RNA export from nucleus;termination of RNA polymerase II transcription","mRNA binding;RNA binding","catalytic step 2 spliceosome;cytoplasm;cytosol;dendrite;exon-exon junction complex;neuronal cell body;nuclear speck;nucleoplasm;nucleus","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,3,3,3,"32.2","32.2","32.2","19.889",0,"16.108",166170000,18,"0.28437","0.745901","0.538447","0.774728","sp|Q9Y5S9|RBM8A_HUMAN;tr|A0A0J9YW13|A0A0J9YW13_HUMAN","sp|Q9Y5S9|RBM8A_HUMAN",3027,"Q9Y5S9","RBM8A_HUMAN","RNA-binding protein 8A",null,"RBM8A"]
["19.4426","19.2633","19.9844","17.645",{"$nulls":3},"nuclear-transcribed mRNA catabolic process;ribosomal large subunit assembly;rRNA processing","RNA binding","cytoplasm;nucleolus",{"$nulls":3},2,2,2,"14.6","14.6","14.6","27.56","0.00039339","3.2342",103750000,9,"0.160275","0.866411","0.538273","0.458831","sp|Q9UKD2|MRT4_HUMAN","sp|Q9UKD2|MRT4_HUMAN",2866,"Q9UKD2","MRT4_HUMAN","mRNA turnover protein 4 homolog {ECO:0000250|UniProtKB:P33201}",null,"MRTO4"]
["23.6171","23.0308","23.7089","21.8659",{"$nulls":3},"cellular response to dexamethasone stimulus;chromatin remodeling;covalent chromatin modification;negative regulation of G0 to G1 transition;negative regulation of transcription, DNA-templated;rhythmic process;transcription, DNA-templated","enzyme binding;histone methyltransferase binding;identical protein binding;protein domain specific binding","chromatin;chromosome, centromeric region;condensed chromosome, centromeric region;nuclear chromosome, telomeric region;nuclear envelope;nuclear euchromatin;nuclear heterochromatin;nuclear inner membrane;nuclear pericentric heterochromatin;nucleoplasm;nucleus;senescence-associated heterochromatin focus;spindle",{"$nulls":3},4,4,4,23,23,23,"20.811",0,"36.135",427620000,26,"0.197367","0.82361","0.536493","0.554802","sp|Q13185|CBX3_HUMAN;tr|C9JMM0|C9JMM0_HUMAN;tr|B8ZZ43|B8ZZ43_HUMAN;tr|S4R2Y4|S4R2Y4_HUMAN;tr|K7ELA4|K7ELA4_HUMAN;tr|B5MD17|B5MD17_HUMAN;tr|J3KS05|J3KS05_HUMAN;sp|P83916|CBX1_HUMAN","sp|Q13185|CBX3_HUMAN;tr|C9JMM0|C9JMM0_HUMAN;tr|B8ZZ43|B8ZZ43_HUMAN;tr|S4R2Y4|S4R2Y4_HUMAN",1532,"Q13185","CBX3_HUMAN","Chromobox protein homolog 3",null,"CBX3"]
["17.9989","17.9693","18.0213","16.8886",{"$nulls":3},"regulation of apoptotic process",null,"integral component of membrane",{"$nulls":3},2,2,2,"8.9","8.9","8.9","48.871",0,"4.4764",34948000,2,"0.347823","0.687864","0.529146","0.933939","tr|A0A087WTL4|A0A087WTL4_HUMAN;sp|Q9BXK5|B2L13_HUMAN;tr|A0A087WX97|A0A087WX97_HUMAN","tr|A0A087WTL4|A0A087WTL4_HUMAN;sp|Q9BXK5|B2L13_HUMAN;tr|A0A087WX97|A0A087WX97_HUMAN",2497,"A0A087WTL4","A0A087WTL4_HUMAN",null,null,"BCL2L13"]
["19.7276","19.9746","19.4234","19.2236",{"$nulls":4},"structural molecule activity","intermediate filament",{"$nulls":3},9,8,7,"25.6","23.5","21.2","44.643",0,"24.225",154910000,20,"1.09739","0.307947","0.52763","3.32183","tr|E9PBF6|E9PBF6_HUMAN;sp|P20700|LMNB1_HUMAN;tr|A0A0D9SFE5|A0A0D9SFE5_HUMAN;tr|A0A0D9SFY5|A0A0D9SFY5_HUMAN","tr|E9PBF6|E9PBF6_HUMAN;sp|P20700|LMNB1_HUMAN;tr|A0A0D9SFE5|A0A0D9SFE5_HUMAN",746,"E9PBF6","E9PBF6_HUMAN",null,null,"LMNB1"]
["19.1955","19.5272","18.802","18.8696",{"$nulls":4},"metal ion binding",{"$nulls":4},2,2,2,"13.4","13.4","13.4","20.677",0,"4.1784",70838000,9,"1.04608","0.303087","0.525578","3.10529","tr|F8VQR7|F8VQR7_HUMAN;sp|Q16527|CSRP2_HUMAN;tr|F8VW96|F8VW96_HUMAN","tr|F8VQR7|F8VQR7_HUMAN;sp|Q16527|CSRP2_HUMAN;tr|F8VW96|F8VW96_HUMAN",1738,"F8VQR7","F8VQR7_HUMAN",null,null,"CSRP2"]
["20.0577","20.3111","19.8059","19.5124",{"$nulls":3},"cellular iron ion homeostasis;response to iron ion","ferric-chelate reductase activity;metal ion binding;oxidoreductase activity, oxidizing metal ions","brush border membrane;extracellular exosome;integral component of membrane;lysosomal membrane;plasma membrane","Mineral absorption",null,null,3,3,3,"14.3","14.3","14.3","31.641",0,"5.7567",62698000,14,"0.945058","0.295082","0.525231","2.70957","sp|Q53TN4|CYBR1_HUMAN","sp|Q53TN4|CYBR1_HUMAN",1799,"Q53TN4","CYBR1_HUMAN","Cytochrome b reductase 1",null,"CYBRD1"]
["20.2232","20.3228","19.6458","19.8516",{"$nulls":3},"prenylated protein catabolic process;prenylcysteine catabolic process;prenylcysteine metabolic process","chloride-transporting ATPase activity;prenylcysteine oxidase activity","extracellular exosome;lysosome;plasma membrane;vacuolar membrane;very-low-density lipoprotein particle","Terpenoid backbone biosynthesis",null,null,5,5,5,"14.5","14.5","14.5","56.639",0,"14.588",216450000,23,"1.35268","0.33431","0.524255","4.5866","sp|Q9UHG3|PCYOX_HUMAN;tr|F8W8W4|F8W8W4_HUMAN;tr|C9K055|C9K055_HUMAN;tr|C9JGT6|C9JGT6_HUMAN;tr|C9JM55|C9JM55_HUMAN","sp|Q9UHG3|PCYOX_HUMAN;tr|F8W8W4|F8W8W4_HUMAN",2833,"Q9UHG3","PCYOX_HUMAN","Prenylcysteine oxidase 1",null,"PCYOX1"]
["19.1463","18.5153","18.6369","17.9816",{"$nulls":3},"post-Golgi vesicle-mediated transport;protein transport",null,"extracellular exosome;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;recycling endosome membrane;trans-Golgi network membrane;transport vesicle",{"$nulls":3},2,2,2,"9.7","9.7","9.7","36.648",0,"22.348",30210000,7,"0.431607","0.578295","0.521574","1.14676","sp|O15127|SCAM2_HUMAN;tr|H3BV04|H3BV04_HUMAN;tr|H3BN93|H3BN93_HUMAN;tr|H3BUB6|H3BUB6_HUMAN;tr|H3BPL9|H3BPL9_HUMAN","sp|O15127|SCAM2_HUMAN;tr|H3BV04|H3BV04_HUMAN;tr|H3BN93|H3BN93_HUMAN;tr|H3BUB6|H3BUB6_HUMAN;tr|H3BPL9|H3BPL9_HUMAN",199,"O15127","SCAM2_HUMAN","Secretory carrier-associated membrane protein 2","ecretory carrier membrane protein 2","SCAMP2"]
["21.2087","21.0114","19.9608","21.2384",{"$nulls":9},2,2,2,37,37,37,"10.2",0,"34.142",137890000,14,"0.290328","0.739931","0.510405","0.789667","tr|Q5VTU3|Q5VTU3_HUMAN;sp|P63172|DYLT1_HUMAN","tr|Q5VTU3|Q5VTU3_HUMAN;sp|P63172|DYLT1_HUMAN",1345,"Q5VTU3","Q5VTU3_HUMAN"]
["19.1887","19.3207","19.0759","18.4225",{"$nulls":3},"galactose catabolic process","identical protein binding;protein homodimerization activity;UDP-glucose 4-epimerase activity;UDP-N-acetylglucosamine 4-epimerase activity","cytosol;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Metabolic pathways",null,null,5,5,5,"36.2","36.2","36.2","38.281",0,"50.059",67935000,19,"0.570908","0.467647","0.505548","1.5168","sp|Q14376|GALE_HUMAN;tr|Q5QPP3|Q5QPP3_HUMAN;tr|Q5QPP4|Q5QPP4_HUMAN;tr|Q5QPP1|Q5QPP1_HUMAN;tr|Q5QPP9|Q5QPP9_HUMAN","sp|Q14376|GALE_HUMAN;tr|Q5QPP3|Q5QPP3_HUMAN;tr|Q5QPP4|Q5QPP4_HUMAN",1621,"Q14376","GALE_HUMAN","UDP-glucose 4-epimerase {ECO:0000303|PubMed:22654673}",null,"GALE"]
["22.0848","22.296","22.2336","21.1375",{"$nulls":3},"histone mRNA metabolic process;mRNA splicing, via spliceosome;nuclear import;RNA splicing;spliceosomal snRNP assembly;termination of RNA polymerase II transcription","RNA binding","catalytic step 2 spliceosome;cytosol;methylosome;nucleoplasm;pICln-Sm protein complex;small nuclear ribonucleoprotein complex;small nucleolar ribonucleoprotein complex;SMN-Sm protein complex;spliceosomal complex;U1 snRNP;U12-type spliceosomal complex;U4 snRNP;U7 snRNP","Spliceosome",null,null,2,2,2,"23.3","23.3","23.3","9.7251",0,"26.09",132900000,13,"0.336139","0.697367","0.504868","0.904566","sp|P62306|RUXF_HUMAN;tr|A0A0B4J254|A0A0B4J254_HUMAN;tr|F8W0W6|F8W0W6_HUMAN","sp|P62306|RUXF_HUMAN;tr|A0A0B4J254|A0A0B4J254_HUMAN;tr|F8W0W6|F8W0W6_HUMAN",1302,"P62306","RUXF_HUMAN","Small nuclear ribonucleoprotein F","nRNP-F","SNRPF"]
["20.1897","20.432","20.347","19.2651",{"$nulls":5},"actin cytoskeleton;cytosol",{"$nulls":3},5,3,1,"19.6","13.9","4.9","28.524",0,"77.956",163400000,12,"0.338518","0.697983","0.504748","0.910544","tr|F5H7S3|F5H7S3_HUMAN;tr|H7BYY1|H7BYY1_HUMAN;tr|B7Z596|B7Z596_HUMAN;tr|H0YK48|H0YK48_HUMAN;tr|H0YNC7|H0YNC7_HUMAN;tr|H0YL42|H0YL42_HUMAN;tr|H0YN06|H0YN06_HUMAN;tr|H0YK20|H0YK20_HUMAN","tr|F5H7S3|F5H7S3_HUMAN;tr|H7BYY1|H7BYY1_HUMAN;tr|B7Z596|B7Z596_HUMAN;tr|H0YK48|H0YK48_HUMAN;tr|H0YNC7|H0YNC7_HUMAN",3072,"F5H7S3","F5H7S3_HUMAN",null,null,"TPM1"]
["20.319","20.142","19.4894","19.9672",{"$nulls":3},"endosome to lysosome transport;membrane organization;receptor-mediated endocytosis;secretion of lysosomal enzymes","mannose binding;mannose transmembrane transporter activity;retromer complex binding;transmembrane signaling receptor activity","clathrin-coated vesicle membrane;endosome;integral component of plasma membrane;late endosome;lysosomal membrane;membrane;perinuclear region of cytoplasm;plasma membrane;trans-Golgi network;trans-Golgi network membrane;transport vesicle","Lysosome;Phagosome",null,null,2,2,2,"11.6","11.6","11.6","30.993",0,"6.4269",146680000,16,"0.727025","0.350803","0.502212","1.97113","sp|P20645|MPRD_HUMAN;tr|F5GXE0|F5GXE0_HUMAN;tr|H0YGE9|H0YGE9_HUMAN;tr|F5GXU0|F5GXU0_HUMAN;tr|H0YGT2|H0YGT2_HUMAN;tr|F5H883|F5H883_HUMAN;tr|F5GX30|F5GX30_HUMAN","sp|P20645|MPRD_HUMAN;tr|F5GXE0|F5GXE0_HUMAN;tr|H0YGE9|H0YGE9_HUMAN;tr|F5GXU0|F5GXU0_HUMAN;tr|H0YGT2|H0YGT2_HUMAN;tr|F5H883|F5H883_HUMAN;tr|F5GX30|F5GX30_HUMAN",745,"P20645","MPRD_HUMAN","Cation-dependent mannose-6-phosphate receptor","D Man-6-P receptor;D-MPR","M6PR"]
["18.3917","18.8538","18.7649","17.4794",{"$nulls":4},"metal ion binding",{"$nulls":4},2,2,2,"6.2","6.2","6.2","34.767","0.0007654","2.9768",71894000,1,"0.267705","0.755455","0.500605","0.732903","tr|A0A087WVI1|A0A087WVI1_HUMAN;sp|Q96JY6|PDLI2_HUMAN;tr|A0A087WXJ0|A0A087WXJ0_HUMAN;tr|B3KPU0|B3KPU0_HUMAN;tr|C9J760|C9J760_HUMAN;tr|C9J0X3|C9J0X3_HUMAN;tr|C9K0F0|C9K0F0_HUMAN;tr|C9JSR2|C9JSR2_HUMAN;tr|C9JS55|C9JS55_HUMAN","tr|A0A087WVI1|A0A087WVI1_HUMAN;sp|Q96JY6|PDLI2_HUMAN;tr|A0A087WXJ0|A0A087WXJ0_HUMAN;tr|B3KPU0|B3KPU0_HUMAN;tr|C9J760|C9J760_HUMAN;tr|C9J0X3|C9J0X3_HUMAN;tr|C9K0F0|C9K0F0_HUMAN;tr|C9JSR2|C9JSR2_HUMAN;tr|C9JS55|C9JS55_HUMAN",2310,"A0A087WVI1","A0A087WVI1_HUMAN",null,null,"PDLIM2"]
["18.805","18.6271","18.4718","17.9593",{"$nulls":4},"sulfotransferase activity",{"$nulls":4},5,5,5,"32.4","32.4","32.4","32.625",0,"23.144",102010000,18,"0.685479","0.377413","0.500486","1.84515","tr|H3BRY5|H3BRY5_HUMAN;sp|P50225|ST1A1_HUMAN;tr|H3BQX5|H3BQX5_HUMAN;sp|P50226|ST1A2_HUMAN;tr|E9PKR8|E9PKR8_HUMAN;tr|E9PKW4|E9PKW4_HUMAN;sp|P0DMN0|ST1A4_HUMAN;sp|P0DMM9|ST1A3_HUMAN;tr|A0A0A6YYL2|A0A0A6YYL2_HUMAN;tr|H3BNY7|H3BNY7_HUMAN;tr|E9PM76|E9PM76_HUMAN","tr|H3BRY5|H3BRY5_HUMAN;sp|P50225|ST1A1_HUMAN;tr|H3BQX5|H3BQX5_HUMAN;sp|P50226|ST1A2_HUMAN",1108,"H3BRY5","H3BRY5_HUMAN","Sulfotransferase {ECO:0000256|RuleBase:RU361155}",null,"SULT1A1"]
["20.3285","20.3487","19.9246","19.754",{"$nulls":3},"regulation of transcription, DNA-templated","DNA binding","chromatin;nucleus",{"$nulls":3},1,1,1,"22.2","22.2","22.2","10.767",0,"3.7444",31644000,8,"1.54752","0.324571","0.499285","5.81263","tr|F5H2U8|F5H2U8_HUMAN;sp|P52926|HMGA2_HUMAN;tr|F5H2A4|F5H2A4_HUMAN;tr|F5H6H0|F5H6H0_HUMAN","tr|F5H2U8|F5H2U8_HUMAN;sp|P52926|HMGA2_HUMAN;tr|F5H2A4|F5H2A4_HUMAN;tr|F5H6H0|F5H6H0_HUMAN",1170,"F5H2U8","F5H2U8_HUMAN",null,null,"HMGA2"]
["15.5663","15.6974","16.0811","14.1954",{"$nulls":3},"hippo signaling;long-term memory;protein ubiquitination;regulation of protein kinase A signaling","metal ion binding;protein kinase A catalytic subunit binding;protein kinase A regulatory subunit binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cell junction;cytoplasm;endoplasmic reticulum membrane;Golgi membrane;intermediate filament cytoskeleton;plasma membrane;postsynaptic density;postsynaptic membrane",{"$nulls":3},1,1,1,"2.4","2.4","2.4","78.213",0,"3.8944",13851000,2,"0.184701","0.835157","0.493582","0.52225","sp|O43164|PJA2_HUMAN","sp|O43164|PJA2_HUMAN",232,"O43164","PJA2_HUMAN","E3 ubiquitin-protein ligase Praja-2","raja2","PJA2"]
["18.3099","18.1595","17.6427","17.8419",{"$nulls":3},"endosomal transport;macroautophagy;membrane invagination;membrane organization;multivesicular body assembly;negative regulation of cell proliferation;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of JAK-STAT cascade;positive regulation of exosomal secretion;positive regulation of gene expression;protein deubiquitination;protein localization to membrane;protein targeting to lysosome;regulation of MAP kinase activity;regulation of protein catabolic process;signal transduction","metal ion binding;protein domain specific binding;ubiquitin-like protein ligase binding","cytosol;early endosome;early endosome membrane;endosome;ESCRT-0 complex;extracellular exosome;intracellular membrane-bounded organelle;lysosome;multivesicular body membrane","Endocytosis;Phagosome",null,null,3,3,3,"6.8","6.8","6.8","86.191",0,"8.3403",70004000,16,"1.23175","0.317824","0.492403","3.94539","sp|O14964|HGS_HUMAN;tr|I3L1E3|I3L1E3_HUMAN;tr|I3L1P5|I3L1P5_HUMAN","sp|O14964|HGS_HUMAN;tr|I3L1E3|I3L1E3_HUMAN",184,"O14964","HGS_HUMAN","Hepatocyte growth factor-regulated tyrosine kinase substrate",null,"HGS"]
["19.5181","19.6779","20.2372","17.9771",{"$nulls":3},"angiogenesis;apoptotic process;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;positive regulation of angiogenesis;positive regulation of endothelial cell proliferation;queuosine biosynthetic process;regulation of peptidyl-tyrosine phosphorylation;viral process","protein binding involved in protein folding;vascular endothelial growth factor receptor 2 binding","cytoplasm;cytosol;nucleus",{"$nulls":3},3,3,3,"14.6","14.6","14.6","27.614",0,"28.351",133080000,10,"0.150545","0.876079","0.490881","0.433292","sp|Q9H2J4|PDCL3_HUMAN","sp|Q9H2J4|PDCL3_HUMAN",2578,"Q9H2J4","PDCL3_HUMAN","Phosducin-like protein 3",null,"PDCL3"]
["17.2492","17.147","18.0061","15.412",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;NLS-bearing protein import into nucleus;nuclear pore organization;protein heterotetramerization;protein heterotrimerization;protein homooligomerization;protein localization to nuclear inner membrane;protein sumoylation;protein targeting;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of protein import into nucleus;tRNA export from nucleus;viral process;viral transcription","nucleocytoplasmic transporter activity;structural constituent of nuclear pore","host cell;nuclear envelope;nuclear membrane;nuclear pore central transport channel","RNA transport",null,null,3,3,3,"9.1","9.1","9.1","55.435",0,"7.134",47192000,7,"0.129267","0.898496","0.489057","0.37677","sp|Q7Z3B4|NUP54_HUMAN","sp|Q7Z3B4|NUP54_HUMAN",1946,"Q7Z3B4","NUP54_HUMAN","Nucleoporin p54",null,"NUP54"]
["18.1125","18.0527","18.5542","16.641",{"$nulls":3},"COPII vesicle coating","identical protein binding","Golgi membrane",{"$nulls":3},1,1,1,"18.5","18.5","18.5","17.731","0.0027778","2.1903",20770000,4,"0.178685","0.841161","0.484962","0.506715","tr|C9JUE0|C9JUE0_HUMAN;tr|C9JJP5|C9JJP5_HUMAN;tr|Q05BK6|Q05BK6_HUMAN;sp|Q92734|TFG_HUMAN","tr|C9JUE0|C9JUE0_HUMAN;tr|C9JJP5|C9JJP5_HUMAN;tr|Q05BK6|Q05BK6_HUMAN;sp|Q92734|TFG_HUMAN",2188,"C9JUE0","C9JUE0_HUMAN",null,null,"TFG"]
["20.2299","20.1316","20.1615","19.2328",{"$nulls":3},"axon extension;cellular process;dendrite development;establishment of monopolar cell polarity;microtubule bundle formation;mitochondrion transport along microtubule;negative regulation of intracellular transport;positive regulation of axon extension","microtubule binding;structural molecule activity","cell junction;cytosol;dendritic spine;microtubule;microtubule associated complex;photoreceptor outer segment;plasma membrane;postsynaptic density",{"$nulls":3},36,36,36,"26.9","26.9","26.9","270.63",0,"323.31",1342000000,172,"0.388058","0.634727","0.483569","1.03556","sp|P46821|MAP1B_HUMAN;tr|D6RA32|D6RA32_HUMAN;tr|D6RA40|D6RA40_HUMAN;tr|D6RCL2|D6RCL2_HUMAN;tr|D6RGJ3|D6RGJ3_HUMAN","sp|P46821|MAP1B_HUMAN",1038,"P46821","MAP1B_HUMAN","Microtubule-associated protein 1B","AP-1B","MAP1B"]
["16.0387",1,"15.0838",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"4.8","4.8","4.8","113.9",0,"4.9932",16441000,3,"0.0144626","0.979755","0.477436","0.0463445","tr|A0A0A0MRH6|A0A0A0MRH6_HUMAN;sp|Q5JRA6|MIA3_HUMAN","tr|A0A0A0MRH6|A0A0A0MRH6_HUMAN;sp|Q5JRA6|MIA3_HUMAN",1811,"A0A0A0MRH6","A0A0A0MRH6_HUMAN",null,null,"MIA3"]
["23.3215","23.2953","22.9103","22.7571",{"$nulls":3},"2-oxoglutarate metabolic process;female gonad development;glutathione metabolic process;glyoxylate cycle;isocitrate metabolic process;NADPH regeneration;neutrophil degranulation;regulation of phospholipid biosynthetic process;regulation of phospholipid catabolic process;response to oxidative stress;response to steroid hormone;tricarboxylic acid cycle","(R)-2-hydroxyglutarate dehydrogenase activity;cadherin binding;identical protein binding;isocitrate dehydrogenase (NADP+) activity;magnesium ion binding;NAD binding;NADP binding;protein homodimerization activity;receptor binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;mitochondrion;peroxisomal matrix;peroxisome;secretory granule lumen;tertiary granule lumen","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Central carbon metabolism in cancer;Citrate cycle (TCA cycle);Glutathione metabolism;Metabolic pathways;Peroxisome",null,null,11,11,11,"37.9","37.9","37.9","46.659",0,"268.8",2283400000,60,"1.58875","0.336876","0.474703","6.10734","sp|O75874|IDHC_HUMAN;tr|C9J4N6|C9J4N6_HUMAN;tr|C9JJE5|C9JJE5_HUMAN;tr|C9JLU6|C9JLU6_HUMAN","sp|O75874|IDHC_HUMAN",371,"O75874","IDHC_HUMAN","Isocitrate dehydrogenase [NADP] cytoplasmic","DH","IDH1"]
["20.8463","20.9338","20.4271","20.4116",{"$nulls":3},"actin cytoskeleton organization;actin filament bundle assembly;anatomical structure morphogenesis;cell migration;cell motility;cell proliferation;cell-cell junction assembly;establishment of apical/basal cell polarity;microspike assembly;positive regulation of extracellular matrix disassembly;positive regulation of filopodium assembly;positive regulation of lamellipodium assembly;positive regulation of podosome assembly;regulation of actin cytoskeleton organization;regulation of microvillus assembly","actin binding;actin filament binding;cadherin binding;drug binding;protein binding, bridging;RNA binding","actin cytoskeleton;cell projection membrane;cell-cell junction;cytoplasm;cytoskeleton;cytosol;extracellular exosome;filamentous actin;filopodium;growth cone;invadopodium;lamellipodium;microspike;microvillus;myelin sheath;podosome;ruffle;stress fiber","MicroRNAs in cancer",null,null,8,8,8,"24.9","24.9","24.9","54.529",0,"42.453",666680000,39,"2.05583","0.4168","0.470702","10.5934","sp|Q16658|FSCN1_HUMAN","sp|Q16658|FSCN1_HUMAN",1749,"Q16658","FSCN1_HUMAN","Fascin",null,"FSCN1"]
["22.1406","22.08","21.9155","21.3787",{"$nulls":3},"protein sumoylation","ATP binding;enzyme activator activity;magnesium ion binding;protein heterodimerization activity;small protein activating enzyme binding;SUMO activating enzyme activity;SUMO binding;transcription factor binding;ubiquitin-like protein conjugating enzyme binding","cytoplasm;nucleoplasm;SUMO activating enzyme complex","Ubiquitin mediated proteolysis",null,null,15,15,15,"30.9","30.9","30.9","71.223",0,"323.31",1107900000,67,"0.641043","0.403251","0.463167","1.71469","sp|Q9UBT2|SAE2_HUMAN;tr|K7ESK7|K7ESK7_HUMAN;tr|K7EPL2|K7EPL2_HUMAN;tr|U3KQ93|U3KQ93_HUMAN;tr|U3KQ55|U3KQ55_HUMAN;tr|K7ES38|K7ES38_HUMAN","sp|Q9UBT2|SAE2_HUMAN",2811,"Q9UBT2","SAE2_HUMAN","SUMO-activating enzyme subunit 2",null,"UBA2"]
["16.6858","16.343","16.0384","16.0693",{"$nulls":3},"axon extension;signal transduction",null,"cytoskeleton;cytosol;filopodium;lamellipodium;nuclear body;plasma membrane",{"$nulls":3},2,2,2,"3.7","3.7","3.7","135.25","0.0010811","2.4708",54141000,11,"0.936216","0.298006","0.460563","2.67672","sp|Q70E73|RAPH1_HUMAN;tr|C9K0J5|C9K0J5_HUMAN;tr|C9J164|C9J164_HUMAN","sp|Q70E73|RAPH1_HUMAN;tr|C9K0J5|C9K0J5_HUMAN;tr|C9J164|C9J164_HUMAN",1922,"Q70E73","RAPH1_HUMAN","Ras-associated and pleckstrin homology domains-containing protein 1","APH1","RAPH1"]
["17.5415","16.9571","17.4057","16.172",{"$nulls":3},"mRNA splicing, via spliceosome;regulation of DNA-templated transcription, elongation;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;viral genome replication","RNA binding","nucleoplasm;nucleus;U2 snRNP;U2-type spliceosomal complex",{"$nulls":3},3,3,3,6,6,6,"85.852",0,"16.084",76025000,14,"0.244557","0.784431","0.460487","0.674653","sp|O43719|HTSF1_HUMAN","sp|O43719|HTSF1_HUMAN",262,"O43719","HTSF1_HUMAN","HIV Tat-specific factor 1","at-SF1","HTATSF1"]
["17.1609","17.4923","17.7356","15.9976",{"$nulls":3},"intracellular protein transport","SNAP receptor activity","intracellular;membrane",{"$nulls":3},2,2,2,12,12,12,"35.42",0,"27.402",22367000,6,"0.183827","0.832644","0.460029","0.519996","tr|D6RF48|D6RF48_HUMAN;sp|Q9P2W9|STX18_HUMAN;tr|D6RC71|D6RC71_HUMAN","tr|D6RF48|D6RF48_HUMAN;sp|Q9P2W9|STX18_HUMAN;tr|D6RC71|D6RC71_HUMAN",2795,"D6RF48","D6RF48_HUMAN",null,null,"STX18"]
["17.2587","19.6251","16.395","19.5694",{"$nulls":3},"arginine catabolic process;citrulline metabolic process;negative regulation of apoptotic process;nitric oxide biosynthetic process;nitric oxide mediated signal transduction;positive regulation of nitric oxide biosynthetic process;regulation of nitric-oxide synthase activity","amino acid binding;catalytic activity;dimethylargininase activity","cytosol;extracellular exosome;microtubule organizing center;mitochondrion",{"$nulls":3},2,2,2,"12.3","12.3","12.3","29.644",0,"9.8785",35784000,4,"0.0767623","0.930809","0.459665","0.232187","sp|O95865|DDAH2_HUMAN;tr|H0Y7N1|H0Y7N1_HUMAN;tr|Q5SSV3|Q5SSV3_HUMAN;tr|Q5SRR8|Q5SRR8_HUMAN","sp|O95865|DDAH2_HUMAN;tr|H0Y7N1|H0Y7N1_HUMAN;tr|Q5SSV3|Q5SSV3_HUMAN;tr|Q5SRR8|Q5SRR8_HUMAN",456,"O95865","DDAH2_HUMAN","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2","DAH-2;imethylarginine dimethylaminohydrolase 2","DDAH2"]
["18.3699","18.0481","18.2393","17.2599",{"$nulls":9},1,1,1,"9.3","9.3","9.3","24.198","0.00039063","3.1677",18339000,8,"0.330791","0.703205","0.459377","0.891137","tr|Q5VW33|Q5VW33_HUMAN;tr|F5GXQ0|F5GXQ0_HUMAN;sp|Q5VW32|BROX_HUMAN","tr|Q5VW33|Q5VW33_HUMAN;tr|F5GXQ0|F5GXQ0_HUMAN;sp|Q5VW32|BROX_HUMAN",1845,"Q5VW33","Q5VW33_HUMAN",null,null,"BROX"]
["20.0167","19.9159","19.4579","19.5571",{"$nulls":3},"RNA phosphodiester bond hydrolysis, exonucleolytic;rRNA catabolic process","3'-5' exonuclease activity;5'-3' exonuclease activity;RNA binding",{"$nulls":4},2,2,2,"19.9","19.9","19.9","18.419",0,"7.8103",58902000,8,"1.63958","0.328259","0.458854","6.48963","sp|Q9BQ61|CS043_HUMAN;tr|K7ELS0|K7ELS0_HUMAN;tr|K7ERU7|K7ERU7_HUMAN;tr|K7EN60|K7EN60_HUMAN","sp|Q9BQ61|CS043_HUMAN;tr|K7ELS0|K7ELS0_HUMAN;tr|K7ERU7|K7ERU7_HUMAN;tr|K7EN60|K7EN60_HUMAN",2413,"Q9BQ61","TRIR_HUMAN","Telomerase RNA component interacting RNase {ECO:0000303|PubMed:28322335, ECO:0000312|HGNC:HGNC:28424}",null,"TRIR"]
["20.7356","20.8532","21.0188","19.655",{"$nulls":3},"isocitrate metabolic process;tricarboxylic acid cycle","electron transfer activity;isocitrate dehydrogenase (NAD+) activity;magnesium ion binding;NAD binding","mitochondrial matrix;mitochondrion;nucleus","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways",null,null,5,5,5,"16.6","16.6","16.6","42.183",0,"51.69",295870000,24,"0.242112","0.784434","0.457529","0.668484","sp|O43837|IDH3B_HUMAN;tr|A0A087WZN1|A0A087WZN1_HUMAN;tr|A0A087X2E5|A0A087X2E5_HUMAN;tr|A0A0D9SG66|A0A0D9SG66_HUMAN","sp|O43837|IDH3B_HUMAN;tr|A0A087WZN1|A0A087WZN1_HUMAN;tr|A0A087X2E5|A0A087X2E5_HUMAN;tr|A0A0D9SG66|A0A0D9SG66_HUMAN",271,"O43837","IDH3B_HUMAN","Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial",null,"IDH3B"]
["18.0822","18.1849","17.9475","17.4078",{"$nulls":3},"arginyl-tRNA aminoacylation","arginine-tRNA ligase activity;ATP binding","cytoplasm",{"$nulls":3},1,1,1,"6.8","6.8","6.8","23.155",0,"12.567",24268000,1,"0.621805","0.42259","0.455849","1.65948","tr|H0Y450|H0Y450_HUMAN;sp|Q5T160|SYRM_HUMAN","tr|H0Y450|H0Y450_HUMAN;sp|Q5T160|SYRM_HUMAN",1828,"H0Y450","H0Y450_HUMAN",null,null,"RARS2"]
["18.1321","18.4614","18.0749","17.6114",{"$nulls":3},"galactitol metabolic process;galactose catabolic process;galactose metabolic process;glycolytic process from galactose","ATP binding;galactokinase activity;galactose binding","cytoplasm;cytosol;extracellular exosome;membrane","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Metabolic pathways",null,null,3,3,3,"9.4","9.4","9.4","42.272",0,"4.4467",48208000,3,"0.599235","0.438521","0.453641","1.59563","sp|P51570|GALK1_HUMAN;tr|K7ERJ9|K7ERJ9_HUMAN;tr|K7ERN9|K7ERN9_HUMAN;tr|K7EII7|K7EII7_HUMAN","sp|P51570|GALK1_HUMAN;tr|K7ERJ9|K7ERJ9_HUMAN",1136,"P51570","GALK1_HUMAN","Galactokinase",null,"GALK1"]
["19.632","18.7859","18.9229","18.5898",{"$nulls":9},2,2,2,13,13,13,"13.623",0,"41.486",22521000,6,"0.37227","0.652218","0.452616","0.995577","tr|H3BV01|H3BV01_HUMAN;tr|H3BQT9|H3BQT9_HUMAN;tr|J3KRT1|J3KRT1_HUMAN;sp|Q92620|PRP16_HUMAN","tr|H3BV01|H3BV01_HUMAN;tr|H3BQT9|H3BQT9_HUMAN;tr|J3KRT1|J3KRT1_HUMAN;sp|Q92620|PRP16_HUMAN",2181,"H3BV01","H3BV01_HUMAN",null,null,"DHX38"]
["16.9647","17.0948","17.3964","15.7592",{"$nulls":4},"nucleoside-triphosphate diphosphatase activity;O-methyltransferase activity","cytosol",{"$nulls":3},2,2,2,"6.9","6.9","6.9","68.856",0,"7.0347",31048000,4,"0.195614","0.826315","0.4519","0.550307","sp|O95671|ASML_HUMAN","sp|O95671|ASML_HUMAN",443,"O95671","ASML_HUMAN","N-acetylserotonin O-methyltransferase-like protein","SMTL","ASMTL"]
["18.968","19.0898","18.7442","18.4098",{"$nulls":3},"fucose metabolic process;glycolipid catabolic process;glycosaminoglycan catabolic process;glycoside catabolic process;neutrophil degranulation","alpha-L-fucosidase activity","azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;lysosomal lumen","Lysosome;Other glycan degradation",null,null,4,4,4,"17.6","17.6","17.6","53.688",0,"71.479",115520000,10,"0.898482","0.300154","0.451858","2.53954","sp|P04066|FUCO_HUMAN","sp|P04066|FUCO_HUMAN",489,"P04066","FUCO_HUMAN","Tissue alpha-L-fucosidase",null,"FUCA1"]
["20.2053","19.8508","20.3949","18.7607",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of gene expression;positive regulation of cell cycle G1/S phase transition;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of gene expression;positive regulation of I-kappaB phosphorylation;positive regulation of metallopeptidase activity;positive regulation of NF-kappaB transcription factor activity;positive regulation of proteasomal protein catabolic process;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein localization to endoplasmic reticulum;positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding;positive regulation of transcription from RNA polymerase II promoter;protein K69-linked ufmylation;regulation of intracellular estrogen receptor signaling pathway;response to endoplasmic reticulum stress","RNA polymerase II repressing transcription factor binding;ubiquitin-like protein ligase binding","cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;nucleolus",{"$nulls":3},3,3,3,"15.6","15.6","15.6","35.61",0,"8.3488",125640000,13,"0.191019","0.829643","0.450238","0.538512","sp|Q96HY6|DDRGK_HUMAN;tr|A0A0A0MRX2|A0A0A0MRX2_HUMAN","sp|Q96HY6|DDRGK_HUMAN;tr|A0A0A0MRX2|A0A0A0MRX2_HUMAN",2290,"Q96HY6","DDRGK_HUMAN","DDRGK domain-containing protein 1 {ECO:0000305}",null,"DDRGK1"]
["18.0428","18.1924","18.016","17.3203",{"$nulls":3},"apoptotic process",null,"integral component of membrane;membrane",{"$nulls":3},3,3,3,"12.8","12.8","12.8","62.228",0,"13.742",76160000,7,"0.476513","0.527732","0.449449","1.26332","sp|Q96KA5|CLP1L_HUMAN;tr|G5E9Z2|G5E9Z2_HUMAN","sp|Q96KA5|CLP1L_HUMAN;tr|G5E9Z2|G5E9Z2_HUMAN",2316,"Q96KA5","CLP1L_HUMAN","Cleft lip and palate transmembrane protein 1-like protein","LPTM1-like protein","CLPTM1L"]
["15.1128","16.0987","14.9024","15.4111",{"$nulls":4},"nucleic acid binding","cytosol;nucleoplasm;plasma membrane",{"$nulls":3},2,2,2,"2.2","2.2","2.2","145.44",0,"3.8757",26736000,6,"0.298247","0.732478","0.449007","0.80952","tr|S4R3H4|S4R3H4_HUMAN;tr|E7EQT4|E7EQT4_HUMAN;sp|Q9UKV3|ACINU_HUMAN","tr|S4R3H4|S4R3H4_HUMAN;tr|E7EQT4|E7EQT4_HUMAN;sp|Q9UKV3|ACINU_HUMAN",2877,"S4R3H4","S4R3H4_HUMAN",null,null,"ACIN1"]
["21.1938","19.1376","19.8056","19.6343",{"$nulls":3},"cristae formation",null,"MICOS complex",{"$nulls":3},2,2,2,"22.8","22.8","22.8","13.101",0,"4.7572",61093000,9,"0.150074","0.87572","0.445729","0.43205","tr|G3V1B6|G3V1B6_HUMAN;tr|H7C1U8|H7C1U8_HUMAN;sp|Q9BUR5|MIC26_HUMAN","tr|G3V1B6|G3V1B6_HUMAN;tr|H7C1U8|H7C1U8_HUMAN;sp|Q9BUR5|MIC26_HUMAN",2462,"G3V1B6","G3V1B6_HUMAN",null,null,"APOO"]
["20.964","20.8178","21.1632","19.7313",{"$nulls":4},"enzyme activator activity;heme binding;metal ion binding","integral component of membrane;mitochondrial inner membrane;mitochondrial outer membrane",{"$nulls":3},3,3,3,"40.7","40.7","40.7","16.694",0,"17.232",87785000,14,"0.22156","0.801802","0.443655","0.61648","tr|J3KNF8|J3KNF8_HUMAN;tr|D6RFH4|D6RFH4_HUMAN;tr|H3BUX2|H3BUX2_HUMAN;sp|O43169|CYB5B_HUMAN","tr|J3KNF8|J3KNF8_HUMAN;tr|D6RFH4|D6RFH4_HUMAN;tr|H3BUX2|H3BUX2_HUMAN;sp|O43169|CYB5B_HUMAN",3109,"J3KNF8","J3KNF8_HUMAN"]
["14.8016","15.9259","14.8837","14.9569",{"$nulls":3},"axon development;axon guidance;cell adhesion;cell migration;cell-matrix adhesion;chemotaxis;leukocyte migration;nervous system development;neuron projection development;positive regulation of axon extension;synapse organization","protein domain specific binding","axon;axonal growth cone;cell surface;dendrite;extracellular matrix;focal adhesion;integral component of membrane;neuronal cell body;plasma membrane","Axon guidance;Cell adhesion molecules (CAMs)",null,null,4,4,4,"4.5","4.5","4.5",140,0,"6.632",47818000,8,"0.289316","0.741225","0.443422","0.787131","sp|P32004|L1CAM_HUMAN;tr|H0Y5C3|H0Y5C3_HUMAN","sp|P32004|L1CAM_HUMAN",900,"P32004","L1CAM_HUMAN","Neural cell adhesion molecule L1","CAM-L1;-CAM-L1","L1CAM"]
["16.4093","16.3807","16.0203","15.8831",{"$nulls":9},2,2,2,"2.2","2.2","2.2","85.353",0,"6.6494",23687000,3,"1.61803","0.333292","0.443329","6.32491","tr|E9PQG4|E9PQG4_HUMAN;tr|A0A0A0MRL8|A0A0A0MRL8_HUMAN;tr|A0A0A0MRL9|A0A0A0MRL9_HUMAN;tr|E9PL24|E9PL24_HUMAN;tr|A0A0C4DFQ0|A0A0C4DFQ0_HUMAN;tr|A0A087WVF8|A0A087WVF8_HUMAN;tr|A0A0A0MRM0|A0A0A0MRM0_HUMAN;sp|Q5VU43|MYOME_HUMAN;tr|A0A0A0MRM1|A0A0A0MRM1_HUMAN;tr|A0A087WX83|A0A087WX83_HUMAN;tr|A0A075B749|A0A075B749_HUMAN","tr|E9PQG4|E9PQG4_HUMAN;tr|A0A0A0MRL8|A0A0A0MRL8_HUMAN;tr|A0A0A0MRL9|A0A0A0MRL9_HUMAN;tr|E9PL24|E9PL24_HUMAN;tr|A0A0C4DFQ0|A0A0C4DFQ0_HUMAN;tr|A0A087WVF8|A0A087WVF8_HUMAN;tr|A0A0A0MRM0|A0A0A0MRM0_HUMAN;sp|Q5VU43|MYOME_HUMAN;tr|A0A0A0MRM1|A0A0A0MRM1_HUMAN;tr|A0A087WX83|A0A087WX83_HUMAN;tr|A0A075B749|A0A075B749_HUMAN",1844,"E9PQG4","E9PQG4_HUMAN",null,null,"PDE4DIP"]
["24.021","23.96","23.6135","23.4869",{"$nulls":3},"cellular protein localization;cellular response to hypoxia;establishment or maintenance of microtubule cytoskeleton polarity;IRE1-mediated unfolded protein response;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;muscle organ development;negative regulation of cardiac muscle hypertrophy in response to stress;negative regulation of cell proliferation;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of mesenchymal cell proliferation;negative regulation of release of cytochrome c from mitochondria;nuclear envelope organization;positive regulation of cell aging;protein localization to nucleus;regulation of cell migration;regulation of protein localization to nucleus;regulation of telomere maintenance;sterol regulatory element binding protein import into nucleus;ventricular cardiac muscle cell development","identical protein binding;structural molecule activity","cytosol;extracellular matrix;intermediate filament;lamin filament;nuclear envelope;nuclear lamina;nuclear membrane;nuclear speck;nucleoplasm;nucleus;perinuclear region of cytoplasm","Apoptosis;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM)",null,null,27,27,26,"48.3","48.3","47.1","74.139",0,"172.76",4736200000,142,"1.6103","0.333744","0.44029","6.2668","sp|P02545|LMNA_HUMAN;tr|Q3BDU5|Q3BDU5_HUMAN;tr|Q5TCI8|Q5TCI8_HUMAN;tr|H0YAB0|H0YAB0_HUMAN;tr|A0A0C4DGC5|A0A0C4DGC5_HUMAN","sp|P02545|LMNA_HUMAN;tr|Q3BDU5|Q3BDU5_HUMAN;tr|Q5TCI8|Q5TCI8_HUMAN",480,"P02545","LMNA_HUMAN","Prelamin-A/C",null,"LMNA"]
["21.9828","21.5916","21.3503","21.3459",{"$nulls":3},"acetyl-CoA biosynthetic process from pyruvate;cellular nitrogen compound metabolic process;glucose metabolic process;mitochondrial acetyl-CoA biosynthetic process from pyruvate;pyruvate metabolic process;regulation of acetyl-CoA biosynthetic process from pyruvate;tricarboxylic acid cycle","pyruvate dehydrogenase (acetyl-transferring) activity;pyruvate dehydrogenase activity","extracellular exosome;mitochondrial matrix;mitochondrion;nucleoplasm;nucleus;pyruvate dehydrogenase complex","Carbon metabolism;Central carbon metabolism in cancer;Citrate cycle (TCA cycle);Glucagon signaling pathway;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Pyruvate metabolism",null,null,8,8,8,"29.5","29.5","29.5","39.233",0,"28.648",532730000,33,"0.812707","0.322731","0.439067","2.24468","sp|P11177|ODPB_HUMAN;tr|F8WF02|F8WF02_HUMAN;tr|C9J634|C9J634_HUMAN","sp|P11177|ODPB_HUMAN;tr|F8WF02|F8WF02_HUMAN;tr|C9J634|C9J634_HUMAN",622,"P11177","ODPB_HUMAN","Pyruvate dehydrogenase E1 component subunit beta, mitochondrial","DHE1-B","PDHB"]
["19.9587","19.8757","19.7876","19.1762",{"$nulls":3},"actin filament-based movement;actomyosin structure organization;cell adhesion;mitotic cytokinesis;positive regulation of protein secretion;regulation of cell shape","actin binding;actin filament binding;actin-dependent ATPase activity;ADP binding;ATP binding;ATPase activity;calmodulin binding;microfilament motor activity;mRNA 5'-UTR binding;RNA stem-loop binding","actomyosin;cell cortex;cleavage furrow;cytoplasm;cytosol;extracellular exosome;lamellipodium;midbody;myosin complex;myosin II complex;myosin II filament;nucleus;polysome;stress fiber","Regulation of actin cytoskeleton;Tight junction",null,null,30,22,22,"19.9","14.9","14.9",229,0,"323.31",932730000,87,"0.532054","0.496863","0.435308","1.41088","sp|P35580|MYH10_HUMAN;tr|E7ERA5|E7ERA5_HUMAN","sp|P35580|MYH10_HUMAN",933,"P35580","MYH10_HUMAN","Myosin-10",null,"MYH10"]
["20.5465","20.103","19.5331","20.2507",{"$nulls":3},"carbohydrate metabolic process;N-acetylglucosamine metabolic process","glucosamine-6-phosphate deaminase activity","cytoplasm",{"$nulls":3},2,2,1,"29.4","29.4","18.8","18.217",0,"38.419",68208000,15,"0.38438","0.636369","0.432882","1.02623","tr|D6RB13|D6RB13_HUMAN;tr|D6RAY7|D6RAY7_HUMAN;tr|D6R9P4|D6R9P4_HUMAN;sp|P46926|GNPI1_HUMAN;tr|D6R917|D6R917_HUMAN;tr|D6RFF8|D6RFF8_HUMAN","tr|D6RB13|D6RB13_HUMAN;tr|D6RAY7|D6RAY7_HUMAN;tr|D6R9P4|D6R9P4_HUMAN;sp|P46926|GNPI1_HUMAN;tr|D6R917|D6R917_HUMAN;tr|D6RFF8|D6RFF8_HUMAN",1039,"D6RB13","D6RB13_HUMAN","Glucosamine-6-phosphate isomerase {ECO:0000256|RuleBase:RU361197}",null,"GNPDA1"]
["15.5646","17.091","16.7394","15.051",{"$nulls":3},"intracellular protein transport;vesicle-mediated transport","lipid binding","clathrin adaptor complex;plasma membrane",{"$nulls":3},2,2,2,"8.3","8.3","8.3","49.526","0.0034388","2.0883",43534000,2,"0.130522","0.898696","0.432608","0.380133","tr|A0A087WY71|A0A087WY71_HUMAN;sp|Q96CW1|AP2M1_HUMAN;tr|E9PFW3|E9PFW3_HUMAN;tr|H7C4C3|H7C4C3_HUMAN","tr|A0A087WY71|A0A087WY71_HUMAN;sp|Q96CW1|AP2M1_HUMAN;tr|E9PFW3|E9PFW3_HUMAN;tr|H7C4C3|H7C4C3_HUMAN",2253,"A0A087WY71","A0A087WY71_HUMAN",null,null,"AP2M1"]
["23.4151","22.9453","22.8739","22.6245",{"$nulls":3},"G2/M transition of mitotic cell cycle;protein demethylation","cadherin binding;protein C-terminal methylesterase activity;protein kinase binding;protein phosphatase 2A binding;protein phosphatase binding;protein phosphatase inhibitor activity;protein phosphatase regulator activity","nucleoplasm",{"$nulls":3},12,12,12,"38.6","38.6","38.6","42.315",0,"323.31",2586200000,84,"0.608071","0.427985","0.430983","1.62051","sp|Q9Y570|PPME1_HUMAN","sp|Q9Y570|PPME1_HUMAN",3012,"Q9Y570","PPME1_HUMAN","Protein phosphatase methylesterase 1","ME-1","PPME1"]
["18.9135","18.6764","19.2428","17.4916",{"$nulls":3},"spermine biosynthetic process","spermine synthase activity",{"$nulls":4},2,2,2,9,9,9,"33.367",0,"67.655",81818000,11,"0.169967","0.851501","0.427743","0.484106","tr|H7C2R7|H7C2R7_HUMAN;sp|P52788|SPSY_HUMAN","tr|H7C2R7|H7C2R7_HUMAN;sp|P52788|SPSY_HUMAN",1166,"H7C2R7","H7C2R7_HUMAN",null,null,"SMS"]
["19.7313","19.669","19.399","19.1462",{"$nulls":9},8,8,8,"21.9","21.9","21.9","99.813",0,"26.574",289440000,34,"1.08875","0.309461","0.427588","3.2846","tr|A0A0C4DFT3|A0A0C4DFT3_HUMAN;sp|Q12959|DLG1_HUMAN;tr|E7EQD7|E7EQD7_HUMAN;tr|B4E2H8|B4E2H8_HUMAN;tr|C9IYP1|C9IYP1_HUMAN;tr|H7C166|H7C166_HUMAN;tr|C9JUA9|C9JUA9_HUMAN;tr|C9JN61|C9JN61_HUMAN;tr|C9JCP6|C9JCP6_HUMAN;tr|A8MUT6|A8MUT6_HUMAN","tr|A0A0C4DFT3|A0A0C4DFT3_HUMAN;sp|Q12959|DLG1_HUMAN;tr|E7EQD7|E7EQD7_HUMAN",3066,"A0A0C4DFT3","A0A0C4DFT3_HUMAN",null,null,"DLG1"]
["25.1772","25.1131","25.1117","24.3288",{"$nulls":9},17,17,13,"47.4","47.4","34.1","27.175",0,"251.29",4903400000,129,"0.406292","0.613081","0.424912","1.08193","tr|Q5HYB6|Q5HYB6_HUMAN;tr|A0A087WWU8|A0A087WWU8_HUMAN;tr|Q5VU61|Q5VU61_HUMAN;tr|J3KN67|J3KN67_HUMAN;tr|D6R904|D6R904_HUMAN;sp|P06753|TPM3_HUMAN;tr|D6RFM2|D6RFM2_HUMAN","tr|Q5HYB6|Q5HYB6_HUMAN;tr|A0A087WWU8|A0A087WWU8_HUMAN;tr|Q5VU61|Q5VU61_HUMAN;tr|J3KN67|J3KN67_HUMAN",3116,"Q5HYB6","Q5HYB6_HUMAN",null,null,"DKFZp686J1372"]
["18.6571",1,"17.8078",1,{"$nulls":3},"branched-chain amino acid catabolic process;fatty acid beta-oxidation using acyl-CoA dehydrogenase;leucine catabolic process","flavin adenine dinucleotide binding;isovaleryl-CoA dehydrogenase activity","mitochondrial matrix","Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,2,2,2,"5.2","5.2","5.2","46.319","0.00039463","3.2807",40171000,2,"0.0108306","0.982803","0.424693","0.0348427","sp|P26440|IVD_HUMAN;tr|A0A0A0MT83|A0A0A0MT83_HUMAN;tr|H0YKV0|H0YKV0_HUMAN;tr|H0YN10|H0YN10_HUMAN;tr|H0YLC3|H0YLC3_HUMAN;tr|H7C4G6|H7C4G6_HUMAN","sp|P26440|IVD_HUMAN;tr|A0A0A0MT83|A0A0A0MT83_HUMAN;tr|H0YKV0|H0YKV0_HUMAN;tr|H0YN10|H0YN10_HUMAN;tr|H0YLC3|H0YLC3_HUMAN;tr|H7C4G6|H7C4G6_HUMAN",811,"P26440","IVD_HUMAN","Isovaleryl-CoA dehydrogenase, mitochondrial","VD","IVD"]
["22.3739","22.3142","22.6037","21.2435",{"$nulls":3},"cellular response to interferon-gamma;intracellular protein transport;long-term synaptic potentiation;organelle fusion;positive regulation of catalytic activity;positive regulation of cell adhesion;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of chemotaxis;positive regulation of eosinophil degranulation;positive regulation of immunoglobulin secretion;positive regulation of insulin secretion involved in cellular response to glucose stimulus;positive regulation of protein localization to cell surface;positive regulation of protein localization to plasma membrane;post-Golgi vesicle-mediated transport;regulation of exocytosis;regulation of extrinsic apoptotic signaling pathway via death domain receptors;response to hydroperoxide;SNARE complex assembly;synaptic vesicle fusion to presynaptic active zone membrane;vesicle docking;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane","SNAP receptor activity;SNARE binding;sphingomyelin phosphodiesterase activator activity","basolateral plasma membrane;cell surface;cytosol;dendritic spine;endosome;extracellular exosome;extracellular space;integral component of membrane;intracellular;lamellipodium;lateral loop;membrane;myelin sheath adaxonal region;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;SNARE complex;somatodendritic compartment;specific granule;storage vacuole;synapse;synaptic vesicle;trans-Golgi network;vacuole","SNARE interactions in vesicular transport;Vasopressin-regulated water reabsorption",null,null,6,6,6,"22.9","22.9","22.9","34.18",0,"52.039",724640000,18,"0.222005","0.80183","0.420454","0.617609","sp|Q12846|STX4_HUMAN;tr|C9JFM5|C9JFM5_HUMAN;tr|A0A087WWW0|A0A087WWW0_HUMAN;tr|H3BMK2|H3BMK2_HUMAN","sp|Q12846|STX4_HUMAN;tr|C9JFM5|C9JFM5_HUMAN",1499,"Q12846","STX4_HUMAN","Syntaxin-4",null,"STX4"]
["19.318","19.0952","18.7394","18.8338",{"$nulls":3},"alpha-linolenic acid metabolic process;bile acid metabolic process;fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA oxidase;neutrophil degranulation;very long-chain fatty acid metabolic process","acetate CoA-transferase activity;acetyl-CoA C-acyltransferase activity;palmitoyl-CoA oxidase activity","extracellular region;intracellular membrane-bounded organelle;membrane;peroxisomal matrix;peroxisome;specific granule lumen","alpha-Linolenic acid metabolism;Biosynthesis of unsaturated fatty acids;Fatty acid degradation;Fatty acid metabolism;Metabolic pathways;Peroxisome;PPAR signaling pathway;Valine, leucine and isoleucine degradation",null,null,5,5,5,"21.5","21.5","21.5","44.292",0,"20.504",101930000,26,"1.13133","0.310407","0.42004","3.47133","sp|P09110|THIK_HUMAN;tr|H7C131|H7C131_HUMAN;tr|C9JDE9|C9JDE9_HUMAN;tr|B4DVF4|B4DVF4_HUMAN;tr|H0Y4D4|H0Y4D4_HUMAN;tr|F2Z2Q6|F2Z2Q6_HUMAN;tr|F2Z3P7|F2Z3P7_HUMAN","sp|P09110|THIK_HUMAN;tr|H7C131|H7C131_HUMAN;tr|C9JDE9|C9JDE9_HUMAN",578,"P09110","THIK_HUMAN","3-ketoacyl-CoA thiolase, peroxisomal",null,"ACAA1"]
["20.3919","20.7378","20.7903","19.5121",{"$nulls":3},"arginine biosynthetic process via ornithine","argininosuccinate lyase activity",{"$nulls":4},1,1,1,"5.8","5.8","5.8","27.379",0,"39.029",155060000,6,"0.224845","0.796994","0.413654","0.624815","tr|F8W943|F8W943_HUMAN;sp|P04424|ARLY_HUMAN","tr|F8W943|F8W943_HUMAN;sp|P04424|ARLY_HUMAN",498,"F8W943","F8W943_HUMAN",null,null,"ASL"]
["19.3079","19.4014","19.498","18.3909",{"$nulls":3},"glutathione derivative biosynthetic process;leukotriene biosynthetic process;lipid metabolic process;response to organonitrogen compound;xenobiotic metabolic process","glutathione peroxidase activity;glutathione transferase activity;leukotriene-C4 synthase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;intracellular membrane-bounded organelle;membrane;nuclear envelope;organelle membrane","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Fluid shear stress and atherosclerosis;Glutathione metabolism;Hepatocellular carcinoma;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pathways in cancer;Platinum drug resistance",null,null,1,1,1,"9.2","9.2","9.2","16.516","0.00075415","2.8445",38517000,7,"0.269885","0.757384","0.410188","0.738379","sp|O14880|MGST3_HUMAN;tr|Q5VV89|Q5VV89_HUMAN","sp|O14880|MGST3_HUMAN;tr|Q5VV89|Q5VV89_HUMAN",177,"O14880","MGST3_HUMAN","Microsomal glutathione S-transferase 3","icrosomal GST-3","MGST3"]
["19.1821","19.0253","18.4288","18.9583",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;osteoblast differentiation;positive regulation of DNA-templated transcription, elongation;regulation of DNA recombination;replication fork processing;RNA export from nucleus;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus;viral process","RNA binding","catalytic step 2 spliceosome;cytosol;extracellular exosome;membrane;nuclear speck;nucleoplasm;transcription export complex","Herpes simplex virus 1 infection;mRNA surveillance pathway;RNA transport;Spliceosome",null,null,3,3,3,21,21,21,"26.888",0,"11.808",57308000,13,"0.559514","0.470505","0.410136","1.48549","sp|Q86V81|THOC4_HUMAN;tr|E9PB61|E9PB61_HUMAN","sp|Q86V81|THOC4_HUMAN;tr|E9PB61|E9PB61_HUMAN",1985,"Q86V81","THOC4_HUMAN","THO complex subunit 4","ho4","ALYREF"]
["20.8338","20.6047","19.9847","20.6482",{"$nulls":3},"cognition;magnesium ion transport;neutrophil degranulation;protein N-linked glycosylation;protein N-linked glycosylation via asparagine;transmembrane transport","magnesium ion transmembrane transporter activity","azurophil granule membrane;endoplasmic reticulum;integral component of plasma membrane;membrane;oligosaccharyltransferase complex;plasma membrane",{"$nulls":3},2,2,2,"5.7","5.7","5.7","38.036",0,"4.4054",219130000,11,"0.431966","0.578367","0.402793","1.14769","sp|Q9H0U3|MAGT1_HUMAN;tr|A0A087WU53|A0A087WU53_HUMAN","sp|Q9H0U3|MAGT1_HUMAN;tr|A0A087WU53|A0A087WU53_HUMAN",2562,"Q9H0U3","MAGT1_HUMAN","Magnesium transporter protein 1","agT1","MAGT1"]
["22.5692","22.2356","22.4353","21.5668",{"$nulls":3},"behavioral response to nutrient;cellular response to organic cyclic compound;centrosome cycle;glucose homeostasis;leukocyte migration;lipid metabolic process;mevalonate transport;monocarboxylic acid transport;plasma membrane lactate transport;pyruvate metabolic process;regulation of insulin secretion;response to food","lactate transmembrane transporter activity;mevalonate transmembrane transporter activity;monocarboxylic acid transmembrane transporter activity;organic cyclic compound binding;protein homodimerization activity;symporter activity","cell junction;centrosome;extracellular exosome;integral component of membrane;integral component of plasma membrane;intracellular membrane-bounded organelle;membrane;mitochondrion;plasma membrane",{"$nulls":3},5,5,5,9,9,9,"53.944",0,"40.975",525810000,27,"0.319505","0.709656","0.401389","0.862817","sp|P53985|MOT1_HUMAN;tr|Q5T8R3|Q5T8R3_HUMAN;tr|Q5T8R5|Q5T8R5_HUMAN","sp|P53985|MOT1_HUMAN",1184,"P53985","MOT1_HUMAN","Monocarboxylate transporter 1","CT 1","SLC16A1"]
["16.8728","16.6364","16.4352","16.2713",{"$nulls":3},"G-protein coupled receptor signaling pathway;response to pheromone",null,"extracellular exosome;integral component of membrane",{"$nulls":3},1,1,1,"3.4","3.4","3.4","49.395","0.00040112","3.392",15187000,9,"0.966516","0.295553","0.40135","2.79043","sp|Q86V85|GP180_HUMAN","sp|Q86V85|GP180_HUMAN",1986,"Q86V85","GP180_HUMAN","Integral membrane protein GPR180",null,"GPR180"]
["17.3856","16.976","19.013","14.5461",{"$nulls":4},"microtubule motor activity","cytoplasm;kinesin complex;microtubule","Salmonella infection",null,null,4,3,3,"9.4","7.4","7.4","68.639",0,"9.4272",61242000,11,"0.058241","0.944618","0.40124","0.178901","sp|Q9NSK0|KLC4_HUMAN;tr|H7C4M1|H7C4M1_HUMAN;tr|C9JZE5|C9JZE5_HUMAN;tr|C9J8T5|C9J8T5_HUMAN","sp|Q9NSK0|KLC4_HUMAN;tr|H7C4M1|H7C4M1_HUMAN;tr|C9JZE5|C9JZE5_HUMAN;tr|C9J8T5|C9J8T5_HUMAN",2694,"Q9NSK0","KLC4_HUMAN","Kinesin light chain 4","LC 4","KLC4"]
["19.5256","19.7255","19.9346","18.5186",{"$nulls":3},"actin cytoskeleton organization;actin filament branching;actin filament bundle assembly;cell migration;cellular response to platelet-derived growth factor stimulus;endothelial cell chemotaxis;negative regulation of Arp2/3 complex-mediated actin nucleation;negative regulation of smooth muscle cell chemotaxis;positive regulation of lamellipodium morphogenesis;protein localization to cell leading edge;regulation of Arp2/3 complex-mediated actin nucleation;ruffle organization;wound healing","actin filament binding;Arp2/3 complex binding;cadherin binding;identical protein binding","actin filament;cell leading edge;cell periphery;cytoplasm;cytosol;extracellular exosome;focal adhesion;lamellipodium;perinuclear region of cytoplasm;plasma membrane;stress fiber",{"$nulls":3},6,6,5,"20.9","20.9","19.4","54.234",0,"55.598",228770000,25,"0.198626","0.82193","0.399008","0.558026","sp|Q9BR76|COR1B_HUMAN;tr|F5H0D2|F5H0D2_HUMAN;tr|A0A087WW53|A0A087WW53_HUMAN;tr|F5H390|F5H390_HUMAN","sp|Q9BR76|COR1B_HUMAN",2423,"Q9BR76","COR1B_HUMAN","Coronin-1B",null,"CORO1B"]
["20.8442","19.8408","20.6966","19.2036",{"$nulls":3},"post-Golgi vesicle-mediated transport;protein transport","ubiquitin protein ligase binding","extracellular exosome;integral component of membrane;intracellular membrane-bounded organelle",{"$nulls":3},4,4,4,"18.7","18.7","18.7","38.287",0,"31.812",155850000,30,"0.151688","0.87649","0.392422","0.436301","sp|O14828|SCAM3_HUMAN","sp|O14828|SCAM3_HUMAN",176,"O14828","SCAM3_HUMAN","Secretory carrier-associated membrane protein 3","ecretory carrier membrane protein 3","SCAMP3"]
["22.2344","21.7668","21.6756","21.5444",{"$nulls":3},"cell proliferation;neutrophil degranulation;pyridoxal 5'-phosphate salvage;pyridoxal phosphate biosynthetic process;vitamin B6 metabolic process","ATP binding;lithium ion binding;magnesium ion binding;potassium ion binding;protein homodimerization activity;pyridoxal kinase activity;pyridoxal phosphate binding;sodium ion binding;zinc ion binding","cytosol;extracellular exosome;extracellular region;nucleus;secretory granule lumen;specific granule lumen","Metabolic pathways;Vitamin B6 metabolism",null,null,11,11,11,"54.5","54.5","54.5","35.102",0,"229.72",581230000,38,"0.603792","0.430765","0.390629","1.60844","sp|O00764|PDXK_HUMAN;tr|F2Z2Y4|F2Z2Y4_HUMAN;tr|A8MV33|A8MV33_HUMAN","sp|O00764|PDXK_HUMAN;tr|F2Z2Y4|F2Z2Y4_HUMAN",156,"O00764","PDXK_HUMAN","Pyridoxal kinase",null,"PDXK"]
["19.4104","19.6913","18.5103","19.8162",{"$nulls":4},"ATP binding;protein kinase activity",{"$nulls":4},3,3,3,"28.9","28.9","28.9","15.642","0.00076923","3.0132",63710000,3,"0.207332","0.81585","0.387564","0.580277","tr|H3BNI9|H3BNI9_HUMAN;sp|P19784|CSK22_HUMAN;tr|H3BSA1|H3BSA1_HUMAN","tr|H3BNI9|H3BNI9_HUMAN;sp|P19784|CSK22_HUMAN",735,"H3BNI9","H3BNI9_HUMAN",null,null,"CSNK2A2"]
["17.9019","18.0096","18.1763","16.9614",{"$nulls":3},"bicellular tight junction assembly;establishment of cell polarity;positive regulation of protein complex assembly;protein localization to adherens junction","cadherin binding;protein complex scaffold activity;protein domain specific binding;protein heterodimerization activity;signaling adaptor activity","adherens junction;bicellular tight junction;cell junction;MPP7-DLG1-LIN7 complex;nucleoplasm",{"$nulls":3},6,6,6,"14.8","14.8","14.8","65.523",0,"11.31",95838000,10,"0.228673","0.793779","0.386941","0.634513","sp|Q5T2T1|MPP7_HUMAN;tr|U5GXS2|U5GXS2_HUMAN;tr|S4R337|S4R337_HUMAN","sp|Q5T2T1|MPP7_HUMAN;tr|U5GXS2|U5GXS2_HUMAN;tr|S4R337|S4R337_HUMAN",1831,"Q5T2T1","MPP7_HUMAN","MAGUK p55 subfamily member 7",null,"MPP7"]
["19.447","19.1276","18.3947","19.4235",{"$nulls":9},2,2,2,"14.3","14.3","14.3","32.64","0.0066423","1.8298",71508000,10,"0.255481","0.768168","0.378186","0.702171","tr|H3BRL3|H3BRL3_HUMAN;sp|O14562|UBFD1_HUMAN;tr|H3BUM8|H3BUM8_HUMAN","tr|H3BRL3|H3BRL3_HUMAN;sp|O14562|UBFD1_HUMAN;tr|H3BUM8|H3BUM8_HUMAN",160,"H3BRL3","H3BRL3_HUMAN",null,null,"UBFD1"]
["21.3986","20.3104","22.3428","18.6301",{"$nulls":3},"iron-sulfur cluster assembly","iron-sulfur cluster binding;methyltransferase activity","cytoplasm",{"$nulls":3},5,5,5,"23.9","23.9","23.9","20.197",0,"64.296",407570000,13,"0.062143","0.940989","0.368021","0.190246","tr|H3BUG4|H3BUG4_HUMAN;tr|H3BV90|H3BV90_HUMAN;tr|H3BT65|H3BT65_HUMAN;sp|Q6FI81|CPIN1_HUMAN;tr|H3BQ23|H3BQ23_HUMAN;tr|H3BPG7|H3BPG7_HUMAN","tr|H3BUG4|H3BUG4_HUMAN;tr|H3BV90|H3BV90_HUMAN;tr|H3BT65|H3BT65_HUMAN;sp|Q6FI81|CPIN1_HUMAN;tr|H3BQ23|H3BQ23_HUMAN;tr|H3BPG7|H3BPG7_HUMAN",1866,"H3BUG4","H3BUG4_HUMAN",null,null,"CIAPIN1"]
["19.8058","19.4665","19.0565","19.4835",{"$nulls":3},"fatty acid beta-oxidation","enoyl-CoA hydratase activity","extracellular exosome;mitochondrial matrix;mitochondrion","beta-Alanine metabolism;Butanoate metabolism;Carbon metabolism;Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Lysine degradation;Metabolic pathways;Propanoate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,4,4,4,19,19,19,"31.387",0,"10.285",125620000,14,"0.506558","0.515066","0.366139","1.34262","sp|P30084|ECHM_HUMAN","sp|P30084|ECHM_HUMAN",862,"P30084","ECHM_HUMAN","Enoyl-CoA hydratase, mitochondrial",null,"ECHS1"]
["16.1997","16.4119","16.2921","15.5892",{"$nulls":9},2,2,2,"6.3","6.3","6.3","56.4",0,"5.1158",12306000,3,"0.371872","0.65318","0.36513","0.994572","tr|A0A087X0S7|A0A087X0S7_HUMAN;tr|A0A0C4DH00|A0A0C4DH00_HUMAN;tr|A0A087WTU1|A0A087WTU1_HUMAN;tr|A0A0B4J2G4|A0A0B4J2G4_HUMAN;sp|Q15345|LRC41_HUMAN","tr|A0A087X0S7|A0A087X0S7_HUMAN;tr|A0A0C4DH00|A0A0C4DH00_HUMAN;tr|A0A087WTU1|A0A087WTU1_HUMAN;tr|A0A0B4J2G4|A0A0B4J2G4_HUMAN;sp|Q15345|LRC41_HUMAN",1692,"A0A087X0S7","A0A087X0S7_HUMAN",null,null,"LRRC41"]
["16.7533","17.1271","16.4741","16.6843",{"$nulls":3},"mRNA splicing, via spliceosome","Hsp70 protein binding","cytosol;intercellular bridge;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"11.5","11.5","11.5","29.841",0,"25.6",17128000,5,"0.630258","0.414651","0.360966","1.68365","sp|O75937|DNJC8_HUMAN","sp|O75937|DNJC8_HUMAN",377,"O75937","DNJC8_HUMAN","DnaJ homolog subfamily C member 8",null,"DNAJC8"]
["23.7767","23.6089","23.7711","22.8971",{"$nulls":3},"antibacterial humoral response;antimicrobial humoral immune response mediated by antimicrobial peptide;defense response to Gram-positive bacterium;innate immune response in mucosa;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular space;nucleoplasm;small ribosomal subunit",{"$nulls":3},2,2,2,"18.6","18.6","18.6","6.6478",0,"3.4738",285160000,7,"0.296821","0.733595","0.358644","0.805946","sp|P62861|RS30_HUMAN;tr|E9PR30|E9PR30_HUMAN","sp|P62861|RS30_HUMAN;tr|E9PR30|E9PR30_HUMAN",1324,"P62861","RS30_HUMAN","40S ribosomal protein S30",null,"FAU"]
["19.3066","18.0704","19.1579","17.5025",{"$nulls":3},"ER to Golgi vesicle-mediated transport",null,"endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi membrane;integral component of membrane;intracellular membrane-bounded organelle;membrane;nucleoplasm",{"$nulls":3},2,2,2,"11.7","11.7","11.7","32.592","0.001402","2.2633",58297000,5,"0.118174","0.903572","0.358344","0.346891","sp|Q969X5|ERGI1_HUMAN","sp|Q969X5|ERGI1_HUMAN",2225,"Q969X5","ERGI1_HUMAN","Endoplasmic reticulum-Golgi intermediate compartment protein 1",null,"ERGIC1"]
["19.2443","18.9009","18.5833","18.8454",{"$nulls":3},"cell adhesion;cell migration;epithelial tube formation;glomerular visceral epithelial cell development;negative regulation of cell adhesion;negative regulation of cell-cell adhesion;positive regulation of cell migration;positive regulation of cell-cell adhesion mediated by integrin;regulation of microvillus assembly",null,"apical plasma membrane;cytoplasm;extracellular exosome;extracellular space;filopodium;integral component of plasma membrane;intracellular membrane-bounded organelle;lamellipodium;membrane raft;microtubule organizing center;microvillus membrane;nucleolus;plasma membrane;ruffle;slit diaphragm",{"$nulls":3},2,2,2,"3.9","3.9","3.9","58.635","0.00039857","3.3429",110180000,3,"0.621528","0.421795","0.35825","1.65869","sp|O00592|PODXL_HUMAN","sp|O00592|PODXL_HUMAN",153,"O00592","PODXL_HUMAN","Podocalyxin",null,"PODXL"]
["18.5292","18.5109","17.8285","18.5068",{"$nulls":3},"apoptotic process;autophagy;brain development;microtubule bundle formation;mitochondrion transport along microtubule;nervous system development;neuron projection morphogenesis;regulation of chromatin disassembly","actin filament binding;beta-tubulin binding;DNA binding;identical protein binding;microtubule binding;tubulin binding","cell junction;cell projection;cytosol;dendrite;microtubule;neuronal cell body;nucleolus;nucleus;perinuclear region of cytoplasm;spindle;synapse",{"$nulls":3},1,1,1,"1.7","1.7","1.7","112.21",0,"29.956",86767000,4,"0.389388","0.633008","0.352439","1.03893","sp|Q66K74|MAP1S_HUMAN","sp|Q66K74|MAP1S_HUMAN",1856,"Q66K74","MAP1S_HUMAN","Microtubule-associated protein 1S","AP-1S","MAP1S"]
["19.5843","19.583","19.3408","19.1243",{"$nulls":5},"intracellular membrane-bounded organelle;nucleoplasm;plasma membrane",{"$nulls":3},5,5,5,"26.6","26.6","26.6","38.398",0,"9.2227",113790000,17,"1.07932","0.305873","0.351108","3.24433","tr|J3KRY8|J3KRY8_HUMAN;sp|Q9BZE9|ASPC1_HUMAN;tr|J3QR12|J3QR12_HUMAN;tr|J3QL04|J3QL04_HUMAN;tr|J3KRF7|J3KRF7_HUMAN","tr|J3KRY8|J3KRY8_HUMAN;sp|Q9BZE9|ASPC1_HUMAN;tr|J3QR12|J3QR12_HUMAN;tr|J3QL04|J3QL04_HUMAN",2517,"J3KRY8","J3KRY8_HUMAN",null,null,"ASPSCR1"]
["22.2675","22.5316","22.8076","21.2914",{"$nulls":3},"cell division;cell proliferation;multicellular organism development;protein folding;sister chromatid cohesion","cadherin binding;unfolded protein binding","cytoplasm;cytosol;microtubule;nucleoplasm",{"$nulls":3},10,10,10,"33.8","33.8","33.8","38.242",0,"282.71",1353500000,51,"0.158742","0.866915","0.349993","0.454818","sp|Q9Y266|NUDC_HUMAN;tr|A0A0A0MSU9|A0A0A0MSU9_HUMAN;tr|A0A0A0MSS4|A0A0A0MSS4_HUMAN","sp|Q9Y266|NUDC_HUMAN",2942,"Q9Y266","NUDC_HUMAN","Nuclear migration protein nudC",null,"NUDC"]
["18.1477","17.6464","18.3628","16.733",{"$nulls":9},3,3,3,"10.3","10.3","10.3","42.846",0,"6.8582",50141000,5,"0.141545","0.884588","0.349131","0.409503","tr|A0A087WXI1|A0A087WXI1_HUMAN;sp|Q6NVY1|HIBCH_HUMAN;tr|B9A058|B9A058_HUMAN;tr|H7C126|H7C126_HUMAN;tr|H7C400|H7C400_HUMAN;tr|F8W8A6|F8W8A6_HUMAN","tr|A0A087WXI1|A0A087WXI1_HUMAN;sp|Q6NVY1|HIBCH_HUMAN;tr|B9A058|B9A058_HUMAN",1876,"A0A087WXI1"]
["21.0122","20.9335","20.963","20.2869",{"$nulls":4},"aminopeptidase activity;metallopeptidase activity;zinc ion binding","cytosol",{"$nulls":3},19,19,19,"27.7","27.7","27.7","102.99",0,"95.012",825640000,72,"0.382789","0.637374","0.347893","1.0222","tr|E9PLK3|E9PLK3_HUMAN;sp|P55786|PSA_HUMAN;sp|A6NEC2|PSAL_HUMAN;tr|E9PP11|E9PP11_HUMAN;tr|H0YDG0|H0YDG0_HUMAN;tr|H0YCQ5|H0YCQ5_HUMAN;tr|E9PJY4|E9PJY4_HUMAN;tr|E9PPD4|E9PPD4_HUMAN;tr|E9PJF9|E9PJF9_HUMAN;tr|E9PJ74|E9PJ74_HUMAN;tr|E9PRQ5|E9PRQ5_HUMAN;tr|E9PPZ2|E9PPZ2_HUMAN","tr|E9PLK3|E9PLK3_HUMAN;sp|P55786|PSA_HUMAN",1212,"E9PLK3","E9PLK3_HUMAN","Aminopeptidase {ECO:0000256|RuleBase:RU364040}",null,"NPEPPS"]
["18.2756","17.6437","18.8143","16.4173",{"$nulls":3},"peptidyl-threonine dephosphorylation;regulation of acetyl-CoA biosynthetic process from pyruvate","[pyruvate dehydrogenase (lipoamide)] phosphatase activity;metal ion binding;protein serine/threonine phosphatase activity","mitochondrial matrix",{"$nulls":3},5,5,5,"14.3","14.3","14.3","61.053",0,"61.607",160370000,18,"0.0928505","0.920013","0.343837","0.277405","sp|Q9P0J1|PDP1_HUMAN;tr|E5RIV4|E5RIV4_HUMAN;tr|E5RIE5|E5RIE5_HUMAN;tr|E5RI96|E5RI96_HUMAN","sp|Q9P0J1|PDP1_HUMAN;tr|E5RIV4|E5RIV4_HUMAN",2772,"Q9P0J1","PDP1_HUMAN","[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial","DP 1","PDP1"]
["18.5642","18.3366","17.7389","18.4853",{"$nulls":3},"intracellular transport of virus;modulation by virus of host process;NLS-bearing protein import into nucleus;protein complex assembly;viral entry into host cell;viral penetration into host nucleus","nuclear localization sequence binding;protein C-terminus binding;protein transporter activity","cytosol;host cell;nuclear pore;nucleoplasm",{"$nulls":3},4,2,2,"11.9","6.1","6.1","57.81",0,"4.3914",79487000,8,"0.321194","0.708657","0.338324","0.867054","sp|O00505|IMA4_HUMAN;tr|H0Y4S9|H0Y4S9_HUMAN","sp|O00505|IMA4_HUMAN",148,"O00505","IMA4_HUMAN","Importin subunit alpha-4",null,"KPNA3"]
["15.1855","15.0344","15.7767","13.7668",{"$nulls":3},"brain development;cell differentiation;spermatogenesis","ATP binding","cytoplasm;mitochondrion","Ribosome biogenesis in eukaryotes",null,null,2,1,1,"2.6","1.2","1.2","97.903","0.0047522","1.9986",12704000,0,"0.114021","0.904315","0.338221","0.33562","sp|Q8NB90|SPAT5_HUMAN","sp|Q8NB90|SPAT5_HUMAN",2069,"Q8NB90","SPAT5_HUMAN","Spermatogenesis-associated protein 5",null,"SPATA5"]
["20.3508","20.1316","20.09","19.7164",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;actin filament network formation;bone development","actin filament binding;calcium ion binding","actin filament;actin filament bundle;cytoplasm;cytosol;plasma membrane",{"$nulls":3},11,11,10,24,24,"21.7","70.81",0,"133.56",419980000,50,"0.586597","0.451141","0.337981","1.56028","sp|P13797|PLST_HUMAN;tr|A0A0A0MSQ0|A0A0A0MSQ0_HUMAN;tr|H7C4N2|H7C4N2_HUMAN;tr|U3KQI3|U3KQI3_HUMAN;tr|Q5TBN3|Q5TBN3_HUMAN;sp|P13796|PLSL_HUMAN;tr|F2Z2Z9|F2Z2Z9_HUMAN","sp|P13797|PLST_HUMAN;tr|A0A0A0MSQ0|A0A0A0MSQ0_HUMAN",662,"P13797","PLST_HUMAN","Plastin-3",null,"PLS3"]
["18.3526","17.8942","18.0069","17.5641",{"$nulls":3},"cellular response to estrogen stimulus;immune response;mast cell mediated immunity;negative regulation by symbiont of host apoptotic process;negative regulation of apoptotic process;negative regulation of endopeptidase activity;positive regulation of gene expression;protection from natural killer cell mediated cytotoxicity;response to bacterium","cysteine-type endopeptidase inhibitor activity involved in apoptotic process;protease binding;serine-type endopeptidase inhibitor activity","cytoplasm;cytosol;extracellular exosome;extracellular space;intracellular;membrane;nucleus","Amoebiasis",null,null,3,3,3,"9.6","9.6","9.6","42.403",0,"4.3985",64205000,9,"0.397778","0.623358","0.337897","1.06025","sp|P50453|SPB9_HUMAN","sp|P50453|SPB9_HUMAN",1113,"P50453","SPB9_HUMAN","Serpin B9",null,"SERPINB9"]
["18.4016","18.4005","18.4649","17.6642",{"$nulls":3},"extracellular negative regulation of signal transduction;negative regulation of amyloid-beta clearance;negative regulation of cell death;negative regulation of protein binding;negative regulation of receptor internalization;negative regulation of very-low-density lipoprotein particle clearance;positive regulation of amyloid-beta clearance;regulation of receptor-mediated endocytosis;transcytosis","amyloid-beta binding;heparin binding;lipase binding;low-density lipoprotein particle receptor binding;receptor antagonist activity;receptor binding;very-low-density lipoprotein particle receptor binding","cell surface;cis-Golgi network;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;endosome;endosome lumen;extracellular region;Golgi apparatus;Golgi lumen;plasma membrane;rough endoplasmic reticulum lumen","Cholesterol metabolism",null,null,2,2,2,"10.6","10.6","10.6","41.465","0.0003917","3.198",77852000,5,"0.310622","0.715709","0.336495","0.840543","sp|P30533|AMRP_HUMAN","sp|P30533|AMRP_HUMAN",874,"P30533","AMRP_HUMAN","Alpha-2-macroglobulin receptor-associated protein","lpha-2-MRAP","LRPAP1"]
["19.6847","19.5439","19.5446","19.0163",{"$nulls":4},"ATP binding;calmodulin binding;calmodulin-dependent protein kinase activity",{"$nulls":4},4,4,4,"12.9","12.9","12.9","56.298",0,"44.433",123280000,22,"0.460358","0.543648","0.333831","1.22113","tr|D6R938|D6R938_HUMAN;sp|Q13557|KCC2D_HUMAN;tr|E9PBG7|E9PBG7_HUMAN;tr|E9PF82|E9PF82_HUMAN;tr|H0Y9J2|H0Y9J2_HUMAN;tr|H0Y9C2|H0Y9C2_HUMAN;tr|H0Y6G2|H0Y6G2_HUMAN;tr|H7BXS4|H7BXS4_HUMAN;tr|Q8WU40|Q8WU40_HUMAN;sp|Q9UQM7|KCC2A_HUMAN;tr|Q5SWX3|Q5SWX3_HUMAN;tr|A0A0A0MS52|A0A0A0MS52_HUMAN;tr|A0A0A0MT11|A0A0A0MT11_HUMAN;sp|Q13555|KCC2G_HUMAN;sp|Q13554|KCC2B_HUMAN","tr|D6R938|D6R938_HUMAN;sp|Q13557|KCC2D_HUMAN;tr|E9PBG7|E9PBG7_HUMAN;tr|E9PF82|E9PF82_HUMAN;tr|H0Y9J2|H0Y9J2_HUMAN;tr|H0Y9C2|H0Y9C2_HUMAN",1570,"D6R938","D6R938_HUMAN"]
["19.4421","19.2771","19.4622","18.5932",{"$nulls":3},"acute inflammatory response to antigenic stimulus;adhesion of symbiont to host;cell adhesion;cell adhesion mediated by integrin;cell aging;cellular response to alkaloid;cellular response to dexamethasone stimulus;cellular response to glucose stimulus;cellular response to hypoxia;cellular response to interleukin-1;cellular response to interleukin-6;cellular response to leukemia inhibitory factor;cellular response to lipopolysaccharide;cellular response to nutrient levels;cellular response to tumor necrosis factor;establishment of endothelial barrier;establishment of endothelial intestinal barrier;establishment of Sertoli cell barrier;extracellular matrix organization;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;interferon-gamma-mediated signaling pathway;leukocyte cell-cell adhesion;leukocyte migration;membrane to membrane docking;negative regulation of calcium ion transport;negative regulation of endothelial cell apoptotic process;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;ovarian follicle development;positive regulation of actin filament polymerization;positive regulation of cellular extravasation;positive regulation of ERK1 and ERK2 cascade;positive regulation of GTPase activity;positive regulation of leukocyte adhesion to vascular endothelial cell;positive regulation of NF-kappaB transcription factor activity;positive regulation of nitric oxide biosynthetic process;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of vasoconstriction;receptor-mediated virion attachment to host cell;regulation of cell shape;regulation of immune response;regulation of leukocyte mediated cytotoxicity;regulation of ruffle assembly;response to amino acid;response to amphetamine;response to copper ion;response to drug;response to ethanol;response to gonadotropin;response to insulin;response to ionizing radiation;response to sulfur dioxide;sensory perception of sound;T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;T cell antigen processing and presentation","integrin binding;receptor activity;transmembrane signaling receptor activity;virus receptor activity","cell surface;external side of plasma membrane;extracellular exosome;extracellular matrix;extracellular space;focal adhesion;immunological synapse;integral component of plasma membrane;membrane;membrane raft;plasma membrane","African trypanosomiasis;AGE-RAGE signaling pathway in diabetic complications;Cell adhesion molecules (CAMs);Epstein-Barr virus infection;Fluid shear stress and atherosclerosis;Human T-cell leukemia virus 1 infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Malaria;Natural killer cell mediated cytotoxicity;NF-kappa B signaling pathway;Rheumatoid arthritis;Staphylococcus aureus infection;TNF signaling pathway;Viral myocarditis",null,null,3,3,3,"8.3","8.3","8.3","57.825",0,"11.704",130220000,11,"0.274664","0.754757","0.331859","0.750375","sp|P05362|ICAM1_HUMAN;tr|E7ESS4|E7ESS4_HUMAN","sp|P05362|ICAM1_HUMAN;tr|E7ESS4|E7ESS4_HUMAN",518,"P05362","ICAM1_HUMAN","Intercellular adhesion molecule 1","CAM-1","ICAM1"]
["22.7809","22.9286","22.8467","22.2017",{"$nulls":3},"calcium ion transport;cell differentiation;cellular calcium ion homeostasis;negative regulation of apoptotic process;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;regulation of apoptotic process;response to virus","calcium ion binding;microtubule binding;RNA binding","cytoplasm;cytosol;extracellular exosome;extracellular space;multivesicular body;nucleus",{"$nulls":3},5,5,5,"23.8","23.8","23.8","19.595",0,"44.779",676920000,34,"0.3737","0.650963","0.330562","0.999191","sp|P13693|TCTP_HUMAN;tr|Q5W0H4|Q5W0H4_HUMAN;tr|A0A0B4J2C3|A0A0B4J2C3_HUMAN;tr|J3KPG2|J3KPG2_HUMAN;sp|Q56UQ5|TPT1L_HUMAN;tr|E9PJF7|E9PJF7_HUMAN;tr|H0YCX0|H0YCX0_HUMAN","sp|P13693|TCTP_HUMAN;tr|Q5W0H4|Q5W0H4_HUMAN;tr|A0A0B4J2C3|A0A0B4J2C3_HUMAN;tr|J3KPG2|J3KPG2_HUMAN;sp|Q56UQ5|TPT1L_HUMAN;tr|E9PJF7|E9PJF7_HUMAN",661,"P13693","TCTP_HUMAN","Translationally-controlled tumor protein","CTP","TPT1"]
["19.9141","19.6485","19.5446","19.3597",{"$nulls":3},"mRNA 3'-splice site recognition;mRNA processing;mRNA splicing, via spliceosome;regulation of alternative mRNA splicing, via spliceosome","RNA binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;spliceosomal complex;U2 snRNP;U2-type prespliceosome;U2-type spliceosomal complex","Spliceosome",null,null,9,9,9,"15.3","15.3","15.3","88.885",0,"81.502",330760000,41,"0.747334","0.342548","0.329197","2.03424","sp|Q15459|SF3A1_HUMAN;tr|F8WC79|F8WC79_HUMAN;tr|F8WB66|F8WB66_HUMAN;tr|H7C1L2|H7C1L2_HUMAN","sp|Q15459|SF3A1_HUMAN",1706,"Q15459","SF3A1_HUMAN","Splicing factor 3A subunit 1",null,"SF3A1"]
["19.7512","20.9596","20.5429","19.5101",{"$nulls":3},"nucleotide biosynthetic process","magnesium ion binding;ribose phosphate diphosphokinase activity",{"$nulls":4},4,4,4,"19.3","19.3","19.3","19.878",0,"34.487",196230000,12,"0.143159","0.882699","0.328896","0.413782","tr|C9JDU5|C9JDU5_HUMAN;tr|C9JJS3|C9JJS3_HUMAN;tr|C9K0K7|C9K0K7_HUMAN;tr|E7EPA1|E7EPA1_HUMAN;sp|O60256|KPRB_HUMAN;tr|I3L331|I3L331_HUMAN;tr|I3L164|I3L164_HUMAN;tr|C9JDH0|C9JDH0_HUMAN;tr|E7EW35|E7EW35_HUMAN;tr|I3L0S1|I3L0S1_HUMAN","tr|C9JDU5|C9JDU5_HUMAN;tr|C9JJS3|C9JJS3_HUMAN;tr|C9K0K7|C9K0K7_HUMAN;tr|E7EPA1|E7EPA1_HUMAN;sp|O60256|KPRB_HUMAN;tr|I3L331|I3L331_HUMAN;tr|I3L164|I3L164_HUMAN;tr|C9JDH0|C9JDH0_HUMAN;tr|E7EW35|E7EW35_HUMAN",282,"C9JDU5","C9JDU5_HUMAN",null,null,"PRPSAP2"]
["18.725",1,1,"18.0699",{"$nulls":3},"eye photoreceptor cell development;response to high light intensity;retina layer formation","NADP-retinol dehydrogenase activity","mitochondrial inner membrane",{"$nulls":3},2,2,2,"8.2","8.2","8.2","35.932",0,"9.023",37138000,2,"0.00825118","0.984297","0.327531","0.0266198","sp|Q8NBN7|RDH13_HUMAN;tr|K7EMY5|K7EMY5_HUMAN;tr|G8JLA1|G8JLA1_HUMAN","sp|Q8NBN7|RDH13_HUMAN;tr|K7EMY5|K7EMY5_HUMAN;tr|G8JLA1|G8JLA1_HUMAN",2075,"Q8NBN7","RDH13_HUMAN","Retinol dehydrogenase 13",null,"RDH13"]
["14.9485","15.0097","14.4307","14.8766",{"$nulls":3},"angiogenesis;cardiac epithelial to mesenchymal transition;cell-matrix adhesion;collagen catabolic process;extracellular matrix disassembly;extracellular matrix organization;immune response to tumor cell;innate immune response;integrin-mediated signaling pathway;male gonad development;negative regulation of cell growth;negative regulation of cell migration;negative regulation of cell-matrix adhesion;negative regulation of receptor binding;protein kinase C signaling;tissue regeneration","integrin binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;SH3 domain binding","acrosomal vesicle;adherens junction;cell projection;cell surface;extracellular exosome;integral component of membrane;plasma membrane",{"$nulls":3},1,1,1,"1.7","1.7","1.7","92.958",0,"14.419",9305400,6,"0.545158","0.485064","0.325482","1.44634","sp|Q13444|ADA15_HUMAN","sp|Q13444|ADA15_HUMAN",1557,"Q13444","ADA15_HUMAN","Disintegrin and metalloproteinase domain-containing protein 15","DAM 15","ADAM15"]
["21.3324","21.1059","21.103","20.6873",{"$nulls":3},"aerobic respiration;aging;cellular response to growth factor stimulus;cellular response to oxidative stress;cholesterol metabolic process;hemoglobin metabolic process;hydrogen peroxide catabolic process;negative regulation of apoptotic process;negative regulation of NF-kappaB transcription factor activity;neutrophil degranulation;osteoblast differentiation;positive regulation of cell division;positive regulation of NF-kappaB transcription factor activity;positive regulation of phosphatidylinositol 3-kinase signaling;protein homotetramerization;protein tetramerization;response to activity;response to cadmium ion;response to drug;response to estradiol;response to ethanol;response to fatty acid;response to hydrogen peroxide;response to hyperoxia;response to hypoxia;response to inactivity;response to insulin;response to L-ascorbic acid;response to lead ion;response to light intensity;response to ozone;response to phenylpropanoid;response to reactive oxygen species;response to vitamin A;response to vitamin E;triglyceride metabolic process;ureteric bud development;UV protection","aminoacylase activity;antioxidant activity;catalase activity;enzyme binding;heme binding;metal ion binding;NADP binding;oxidoreductase activity, acting on peroxide as acceptor;protein homodimerization activity;receptor binding","cytosol;endoplasmic reticulum;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;Golgi apparatus;intracellular membrane-bounded organelle;lysosome;membrane;mitochondrial intermembrane space;mitochondrion;peroxisomal matrix;peroxisomal membrane;peroxisome;plasma membrane;secretory granule lumen","Amyotrophic lateral sclerosis (ALS);Carbon metabolism;FoxO signaling pathway;Glyoxylate and dicarboxylate metabolism;Longevity regulating pathway;Longevity regulating pathway - multiple species;Metabolic pathways;Peroxisome;Tryptophan metabolism",null,null,8,8,8,"15.6","15.6","15.6","59.755",0,"37.697",466750000,37,"0.516341","0.510131","0.323975","1.3687","sp|P04040|CATA_HUMAN","sp|P04040|CATA_HUMAN",487,"P04040","CATA_HUMAN","Catalase",null,"CAT"]
["15.9886","16.3689","16.2253","15.4874",{"$nulls":3},"axonogenesis;endoplasmic reticulum organization;endoplasmic reticulum tubular network membrane organization;protein homooligomerization","GTP binding;GTPase activity;identical protein binding","axon;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum tubular network;endoplasmic reticulum tubular network membrane;Golgi apparatus;Golgi cis cisterna;Golgi membrane;integral component of membrane",{"$nulls":3},2,2,2,"4.1","4.1","4.1","63.543",0,"7.3016",13632000,7,"0.28519","0.745542","0.322436","0.776784","sp|Q8WXF7|ATLA1_HUMAN;tr|H0YJ65|H0YJ65_HUMAN","sp|Q8WXF7|ATLA1_HUMAN;tr|H0YJ65|H0YJ65_HUMAN",2156,"Q8WXF7","ATLA1_HUMAN","Atlastin-1",null,"ATL1"]
["21.4905","21.0266","22.6273","19.2515",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal large subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome;tRNA binding","cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;membrane","Ribosome",null,null,4,4,4,"27.3","27.3","27.3","12.538",0,"4.6378",239460000,7,"0.0611404","0.943068","0.319175","0.187338","sp|P18077|RL35A_HUMAN;tr|F8WBS5|F8WBS5_HUMAN;tr|F8WB72|F8WB72_HUMAN;tr|C9K025|C9K025_HUMAN","sp|P18077|RL35A_HUMAN;tr|F8WBS5|F8WBS5_HUMAN;tr|F8WB72|F8WB72_HUMAN;tr|C9K025|C9K025_HUMAN",717,"P18077","RL35A_HUMAN","60S ribosomal protein L35a",null,"RPL35A"]
["18.6373","18.6211","18.4582","18.1655",{"$nulls":3},"activation of innate immune response;innate immune response;posttranscriptional regulation of gene expression","identical protein binding;miRNA binding;RNA binding;structural molecule activity;zinc ion binding","membrane;nuclear inner membrane;nuclear matrix",{"$nulls":3},6,6,6,"11.6","11.6","11.6","94.622",0,"24.984",104070000,15,"0.788321","0.333159","0.317349","2.16482","sp|P43243|MATR3_HUMAN;tr|A8MXP9|A8MXP9_HUMAN;tr|D6REM6|D6REM6_HUMAN;tr|B3KM87|B3KM87_HUMAN;tr|Q68E03|Q68E03_HUMAN;tr|D6R991|D6R991_HUMAN;tr|D6RAM9|D6RAM9_HUMAN;tr|D6RAY2|D6RAY2_HUMAN;tr|D6RBI2|D6RBI2_HUMAN;tr|D6RE02|D6RE02_HUMAN;tr|D6RIA2|D6RIA2_HUMAN;tr|H0Y8T4|H0Y8T4_HUMAN","sp|P43243|MATR3_HUMAN;tr|A8MXP9|A8MXP9_HUMAN;tr|D6REM6|D6REM6_HUMAN;tr|B3KM87|B3KM87_HUMAN;tr|Q68E03|Q68E03_HUMAN;tr|D6R991|D6R991_HUMAN",1005,"P43243","MATR3_HUMAN","Matrin-3",null,"MATR3"]
["19.5105","19.4323","19.2962","19.012",{"$nulls":4},"heme binding;steroid binding;steroid hormone receptor activity","integral component of membrane;membrane;nuclear envelope",{"$nulls":3},2,2,2,"14.8","14.8","14.8","23.818",0,"3.7368",60075000,9,"0.784555","0.33301","0.317318","2.15264","sp|O15173|PGRC2_HUMAN","sp|O15173|PGRC2_HUMAN",205,"O15173","PGRC2_HUMAN","Membrane-associated progesterone receptor component 2",null,"PGRMC2"]
["18.5436","18.6531","18.6618","17.9008",{"$nulls":3},"CUT catabolic process;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;regulation of mRNA stability;rRNA catabolic process;rRNA processing","3'-5'-exoribonuclease activity;endonuclease activity;guanyl-nucleotide exchange factor activity;RNA binding","cytosol;exosome (RNase complex);membrane;nuclear exosome (RNase complex);nucleoplasm;nucleus","RNA degradation",null,null,5,5,5,"7.1","7.1","7.1",109,0,"45.315",139120000,22,"0.304348","0.724634","0.317054","0.824813","sp|Q9Y2L1|RRP44_HUMAN;tr|F2Z2C0|F2Z2C0_HUMAN;tr|G3V1J5|G3V1J5_HUMAN","sp|Q9Y2L1|RRP44_HUMAN;tr|F2Z2C0|F2Z2C0_HUMAN;tr|G3V1J5|G3V1J5_HUMAN",2952,"Q9Y2L1","RRP44_HUMAN","Exosome complex exonuclease RRP44",null,"DIS3"]
["18.6279","18.3349","19.1664","17.1632",{"$nulls":9},2,2,2,"31.9","31.9","31.9","15.404","0.0075783","1.762",36316000,3,"0.105663","0.913024","0.316628","0.312799","tr|F8WBW1|F8WBW1_HUMAN;sp|Q86X83|COMD2_HUMAN;tr|F8WC41|F8WC41_HUMAN","tr|F8WBW1|F8WBW1_HUMAN;sp|Q86X83|COMD2_HUMAN;tr|F8WC41|F8WC41_HUMAN",1995,"F8WBW1","F8WBW1_HUMAN",null,null,"COMMD2"]
["22.6915","22.5165","22.0224","22.5536",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleolus;nucleoplasm;ribosome","Ribosome",null,null,4,4,2,"23.6","23.6","9.1","18.898",0,"27.688",502530000,20,"0.42503","0.588916","0.315988","1.12987","sp|P46783|RS10_HUMAN;tr|F6U211|F6U211_HUMAN;sp|Q9NQ39|RS10L_HUMAN","sp|P46783|RS10_HUMAN;tr|F6U211|F6U211_HUMAN;sp|Q9NQ39|RS10L_HUMAN",1037,"P46783","RS10_HUMAN","40S ribosomal protein S10",null,"RPS10"]
["22.0474","21.6324","21.5226","21.5281",{"$nulls":3},"G-quadruplex DNA unwinding;interleukin-12-mediated signaling pathway;miRNA transport;mRNA export from nucleus;mRNA processing;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;negative regulation of transcription from RNA polymerase II promoter;positive regulation of telomerase RNA reverse transcriptase activity;positive regulation of telomere maintenance via telomere lengthening;primary miRNA processing;RNA metabolic process;RNA transport","G-rich strand telomeric DNA binding;identical protein binding;miRNA binding;mRNA 3'-UTR binding;N6-methyladenosine-containing RNA binding;pre-mRNA intronic binding;RNA binding;single-stranded telomeric DNA binding","Cajal body;catalytic step 2 spliceosome;chromosome, telomeric region;cytoplasm;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nuclear matrix;nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},7,6,6,"28.3","25.8","25.8","37.429",0,"23.686",570530000,35,"0.570609","0.467238","0.314562","1.51598","sp|P22626|ROA2_HUMAN;tr|A0A087WUI2|A0A087WUI2_HUMAN","sp|P22626|ROA2_HUMAN;tr|A0A087WUI2|A0A087WUI2_HUMAN",768,"P22626","ROA2_HUMAN","Heterogeneous nuclear ribonucleoproteins A2/B1","nRNP A2/B1","HNRNPA2B1"]
["21.9363","21.9946","21.5079","21.7979",{"$nulls":3},"cellular response to insulin stimulus;liver regeneration;mRNA 3'-end processing;mRNA export from nucleus;mRNA processing;mRNA splice site selection;mRNA splicing, via spliceosome;positive regulation of RNA splicing;regulation of cell cycle;RNA export from nucleus;termination of RNA polymerase II transcription","protein kinase B binding;RNA binding","cytosol;nuclear speck;nucleolus;nucleoplasm;nucleus","Herpes simplex virus 1 infection;Spliceosome",null,null,3,3,2,14,14,"10.7","31.263",0,"14.35",294710000,9,"0.772403","0.337635","0.312523","2.11358","sp|Q13243|SRSF5_HUMAN;tr|B4DJK0|B4DJK0_HUMAN;tr|B4DUA4|B4DUA4_HUMAN;tr|A0A0D9SEM4|A0A0D9SEM4_HUMAN;sp|Q08170|SRSF4_HUMAN","sp|Q13243|SRSF5_HUMAN",1535,"Q13243","SRSF5_HUMAN","Serine/arginine-rich splicing factor 5",null,"SRSF5"]
["16.972","16.8411","17.4892","15.7062",{"$nulls":9},1,1,1,"5.8","5.8","5.8","34.88",0,"5.3926",13752000,8,"0.117659","0.904206","0.30884","0.345495","tr|A2AB15|A2AB15_HUMAN;sp|O60231|DHX16_HUMAN","tr|A2AB15|A2AB15_HUMAN;sp|O60231|DHX16_HUMAN",280,"A2AB15","A2AB15_HUMAN",null,null,"DHX16"]
["18.4845","18.3796","18.9821","17.2657",{"$nulls":5},"mitochondrion;nucleoplasm",{"$nulls":3},1,1,1,"9.9","9.9","9.9","17.459",0,"5.3717",29823000,3,"0.122423","0.902368","0.308127","0.358371","tr|C9JU35|C9JU35_HUMAN;sp|Q9NPL8|TIDC1_HUMAN","tr|C9JU35|C9JU35_HUMAN;sp|Q9NPL8|TIDC1_HUMAN",2663,"C9JU35","C9JU35_HUMAN",null,null,"TIMMDC1"]
["17.6012","17.3305","17.2161","17.1001",{"$nulls":4},"ATP binding;biotin carboxylase activity;metal ion binding",{"$nulls":4},3,3,3,"14.1","14.1","14.1","48.216","0.0010889","2.5242",27091000,10,"0.76514","0.33787","0.307758","2.09043","tr|G5E9X5|G5E9X5_HUMAN;tr|E9PG35|E9PG35_HUMAN;tr|E9PHF7|E9PHF7_HUMAN;sp|Q96RQ3|MCCA_HUMAN;tr|F5GYT8|F5GYT8_HUMAN","tr|G5E9X5|G5E9X5_HUMAN;tr|E9PG35|E9PG35_HUMAN;tr|E9PHF7|E9PHF7_HUMAN;sp|Q96RQ3|MCCA_HUMAN;tr|F5GYT8|F5GYT8_HUMAN",2346,"G5E9X5","G5E9X5_HUMAN"]
["18.9674","18.8555","19.2601","17.9492",{"$nulls":3},"transmembrane transport",null,"integral component of membrane",{"$nulls":3},1,1,1,"7.9","7.9","7.9","18.967","0.0014006","2.2548",15917000,4,"0.163125","0.862415","0.306734","0.466281","tr|H3BT44|H3BT44_HUMAN;tr|H3BPQ9|H3BPQ9_HUMAN;sp|Q9H2V7|SPNS1_HUMAN;tr|H3BR82|H3BR82_HUMAN;tr|H3BMF4|H3BMF4_HUMAN","tr|H3BT44|H3BT44_HUMAN;tr|H3BPQ9|H3BPQ9_HUMAN;sp|Q9H2V7|SPNS1_HUMAN;tr|H3BR82|H3BR82_HUMAN;tr|H3BMF4|H3BMF4_HUMAN",2583,"H3BT44","H3BT44_HUMAN",null,null,"SPNS1"]
["19.9349","20.0423","19.6183","19.7459",{"$nulls":3},"antigen processing and presentation;endosome organization;neutrophil degranulation;plasma membrane to endosome transport;protein transport;regulation of endocytosis","GDP binding;GTP binding;GTPase activity;GTP-dependent protein binding","anchored component of synaptic vesicle membrane;early endosome;early endosome membrane;endocytic vesicle;endosome;extracellular exosome;intracellular;intracellular membrane-bounded organelle;melanosome;membrane;plasma membrane;secretory granule membrane","Amoebiasis;Endocytosis;Phagosome;Ras signaling pathway;Tuberculosis;Vasopressin-regulated water reabsorption",null,null,3,2,2,"17.2","12.1","12.1","23.707",0,"7.8546",107210000,14,"1.1759","0.319134","0.306522","3.6757","sp|P61020|RAB5B_HUMAN;tr|F8VWU4|F8VWU4_HUMAN;tr|F8VVZ0|F8VVZ0_HUMAN;tr|F8VUA5|F8VUA5_HUMAN","sp|P61020|RAB5B_HUMAN",1253,"P61020","RAB5B_HUMAN","Ras-related protein Rab-5B",null,"RAB5B"]
["14.6172","14.4952","14.1392","14.3608",{"$nulls":3},"cellular response to cAMP;cellular response to ethanol;platelet activation;regulation of cardiac conduction;regulation of insulin secretion;release of sequestered calcium ion into cytosol;response to hypoxia;signal transduction;transport","calcium ion binding;calcium ion transmembrane transporter activity;inositol 1,4,5 trisphosphate binding;inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;phosphatidylinositol binding;scaffold protein binding","cell cortex;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;nucleus;plasma membrane;platelet dense tubular network membrane;receptor complex;sarcoplasmic reticulum membrane","Aldosterone synthesis and secretion;Alzheimer disease;Apelin signaling pathway;Apoptosis;Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholinergic synapse;Cortisol synthesis and secretion;C-type lectin receptor signaling pathway;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;NOD-like receptor signaling pathway;Oocyte meiosis;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Phosphatidylinositol signaling system;Platelet activation;Proteoglycans in cancer;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Thyroid hormone synthesis;Vascular smooth muscle contraction",null,null,2,2,2,"1.1","1.1","1.1","308.06","0.00039154","3.1966",22784000,4,"0.864605","0.301337","0.306206","2.42038","sp|Q14571|ITPR2_HUMAN","sp|Q14571|ITPR2_HUMAN",1630,"Q14571","ITPR2_HUMAN","Inositol 1,4,5-trisphosphate receptor type 2",null,"ITPR2"]
["16.6658","16.2045","17.0348","15.2234",{"$nulls":3},"intracellular protein transport;regulation of Arp2/3 complex-mediated actin nucleation;regulation of protein secretion","cadherin binding;phosphatidylinositol-4-phosphate binding;protein domain specific binding","cytosol;Golgi membrane;trans-Golgi network membrane",{"$nulls":3},2,2,2,"6.4","6.4","6.4","41.738","0.0097434","1.6717",14808000,2,"0.111041","0.90526","0.306092","0.327506","sp|P53367|ARFP1_HUMAN","sp|P53367|ARFP1_HUMAN",1177,"P53367","ARFP1_HUMAN","Arfaptin-1",null,"ARFIP1"]
["20.3208","20.2409","20.0063","19.9475",{"$nulls":3},"intracellular protein transport;intra-Golgi vesicle-mediated transport;membrane fusion;protein complex assembly;protein stabilization","soluble NSF attachment protein activity;syntaxin binding","extracellular exosome;lysosomal membrane;mitochondrion;myelin sheath;SNARE complex",{"$nulls":3},4,4,4,"14.7","14.7","14.7","34.746",0,"45.178",241800000,20,"1.59089","0.33856","0.303912","6.12294","sp|Q99747|SNAG_HUMAN;tr|J3QS28|J3QS28_HUMAN;tr|J3QKW4|J3QKW4_HUMAN;tr|J3KTJ6|J3KTJ6_HUMAN","sp|Q99747|SNAG_HUMAN",2395,"Q99747","SNAG_HUMAN","Gamma-soluble NSF attachment protein","NAP-gamma","NAPG"]
["22.2363","21.8509","21.8817","21.6071",{"$nulls":3},"cell redox homeostasis","dihydrolipoyl dehydrogenase activity;electron transfer activity;flavin adenine dinucleotide binding","mitochondrion;nucleoplasm",{"$nulls":3},7,7,7,"15.8","15.8","15.8","51.815",0,"28.022",781520000,39,"0.476931","0.527773","0.29917","1.26441","tr|E9PEX6|E9PEX6_HUMAN;sp|P09622|DLDH_HUMAN","tr|E9PEX6|E9PEX6_HUMAN;sp|P09622|DLDH_HUMAN",590,"E9PEX6","E9PEX6_HUMAN","Dihydrolipoyl dehydrogenase {ECO:0000256|RuleBase:RU003692}",null,"DLD"]
["21.1594","20.4907","21.0766","19.9773",{"$nulls":3},"cellular protein metabolic process;neutrophil degranulation;post-translational protein modification","RNA binding","azurophil granule membrane;cytoplasmic ribonucleoprotein granule;cytoskeleton;cytosol;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular exosome;extracellular matrix;integral component of membrane;lamellar body;lipid droplet;membrane;nuclear speck;perinuclear region of cytoplasm;plasma membrane;rough endoplasmic reticulum;specific granule membrane","Protein processing in endoplasmic reticulum",null,null,10,10,10,"22.3","22.3","22.3","66.022",0,"115.39",727140000,48,"0.162008","0.863266","0.298101","0.463363","sp|Q07065|CKAP4_HUMAN","sp|Q07065|CKAP4_HUMAN",1464,"Q07065","CKAP4_HUMAN","Cytoskeleton-associated protein 4",null,"CKAP4"]
["16.914","17.1384","17.1213","16.3384",{"$nulls":3},"inositol biosynthetic process;inositol phosphate metabolic process;phospholipid biosynthetic process","inositol-3-phosphate synthase activity","cytoplasm;cytosol","Inositol phosphate metabolism;Metabolic pathways",null,null,5,5,5,"13.6","13.6","13.6","61.067",0,"5.6219",42133000,9,"0.265675","0.75603","0.296382","0.727802","sp|Q9NPH2|INO1_HUMAN;tr|J3KRH4|J3KRH4_HUMAN;tr|J3QS51|J3QS51_HUMAN","sp|Q9NPH2|INO1_HUMAN",2662,"Q9NPH2","INO1_HUMAN","Inositol-3-phosphate synthase 1","PS 1","ISYNA1"]
["18.1367","17.7784","18.28","17.0493",{"$nulls":3},"cell redox homeostasis",null,"cell;integral component of membrane",{"$nulls":3},2,2,2,"11.1","11.1","11.1","34.037","0.0091473","1.7077",40942000,6,"0.159572","0.866387","0.292889","0.456993","sp|Q9Y320|TMX2_HUMAN","sp|Q9Y320|TMX2_HUMAN",2971,"Q9Y320","TMX2_HUMAN","Thioredoxin-related transmembrane protein 2",null,"TMX2"]
["19.6831","20.0356","19.7625","19.3749",{"$nulls":5},"mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,"9.3","9.3","9.3","33.458","0.0031131","2.1566",75183000,3,"0.417185","0.598965","0.29071","1.10976","tr|H7C213|H7C213_HUMAN;sp|P46199|IF2M_HUMAN","tr|H7C213|H7C213_HUMAN;sp|P46199|IF2M_HUMAN",1026,"H7C213","H7C213_HUMAN",null,null,"MTIF2"]
["18.7153","18.0812","18.1145","18.1021",{"$nulls":3},"regulation of double-strand break repair via homologous recombination","metal ion binding;NF-kappaB-inducing kinase activity;protein serine/threonine phosphatase activity","cytosol;microtubule organizing center;nucleoplasm;nucleus;plasma membrane;protein phosphatase 4 complex","Glucagon signaling pathway",null,null,3,3,3,14,14,14,"35.08",0,"11.516",49794000,7,"0.340132","0.695518","0.290003","0.914601","sp|P60510|PP4C_HUMAN;tr|I3L4X0|I3L4X0_HUMAN;tr|H3BTA2|H3BTA2_HUMAN;tr|H3BV22|H3BV22_HUMAN","sp|P60510|PP4C_HUMAN;tr|I3L4X0|I3L4X0_HUMAN;tr|H3BTA2|H3BTA2_HUMAN",1237,"P60510","PP4C_HUMAN","Serine/threonine-protein phosphatase 4 catalytic subunit","p4;P4C","PPP4C"]
["20.256","20.399","20.1664","19.9106",{"$nulls":4},"nucleic acid binding","nucleus",{"$nulls":3},2,2,2,"21.2","21.2","21.2","16.14",0,"49.521",84314000,14,"0.727398","0.350978","0.288953","1.97228","tr|E7EVL6|E7EVL6_HUMAN;tr|C9JZE3|C9JZE3_HUMAN;tr|C9JYJ8|C9JYJ8_HUMAN;sp|Q9BWE0|REPI1_HUMAN","tr|E7EVL6|E7EVL6_HUMAN;tr|C9JZE3|C9JZE3_HUMAN;tr|C9JYJ8|C9JYJ8_HUMAN;sp|Q9BWE0|REPI1_HUMAN",2484,"E7EVL6","E7EVL6_HUMAN",null,null,"REPIN1"]
["22.3536","22.6584","22.4662","21.9733",{"$nulls":3},"cell proliferation",null,"cytoplasm",{"$nulls":3},9,9,9,"63.2","63.2","63.2","27.335",0,"152.01",597510000,65,"0.369322","0.659352","0.286285","0.98813","sp|Q9UKY7|CDV3_HUMAN;tr|H0Y8K3|H0Y8K3_HUMAN;tr|D6R9V8|D6R9V8_HUMAN;tr|D6RFH2|D6RFH2_HUMAN;tr|D6RDN0|D6RDN0_HUMAN;tr|D6RAV0|D6RAV0_HUMAN;tr|D6R973|D6R973_HUMAN","sp|Q9UKY7|CDV3_HUMAN;tr|H0Y8K3|H0Y8K3_HUMAN;tr|D6R9V8|D6R9V8_HUMAN",2880,"Q9UKY7","CDV3_HUMAN","Protein CDV3 homolog",null,"CDV3"]
["15.7865","15.6267","16.185","14.6563",{"$nulls":3},"choline catabolic process;glycine betaine biosynthetic process from choline","choline dehydrogenase activity;flavin adenine dinucleotide binding","mitochondrial inner membrane","Glycine, serine and threonine metabolism;Metabolic pathways",null,null,1,1,1,"4.2","4.2","4.2","65.358","0.0047265","1.9442",14139000,5,"0.127504","0.896712","0.285933","0.372041","sp|Q8NE62|CHDH_HUMAN","sp|Q8NE62|CHDH_HUMAN",2091,"Q8NE62","CHDH_HUMAN","Choline dehydrogenase, mitochondrial","DH;HD","CHDH"]
["20.0266","19.724","19.6481","19.5348",{"$nulls":3},"mRNA 3'-splice site recognition;mRNA processing;mRNA splicing, via spliceosome;RNA splicing;RNA splicing, via transesterification reactions","RNA binding;zinc ion binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;spliceosomal complex","Spliceosome",null,null,6,6,6,"15.6","15.6","15.6","58.848",0,"24.591",183890000,24,"0.655526","0.390484","0.283845","1.75675","sp|Q12874|SF3A3_HUMAN","sp|Q12874|SF3A3_HUMAN",1502,"Q12874","SF3A3_HUMAN","Splicing factor 3A subunit 3",null,"SF3A3"]
["16.085","15.9143","16.2456","15.1863",{"$nulls":3},"fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA oxidase;internal protein amino acid acetylation","3-hydroxyacyl-CoA dehydrogenase activity;dodecenoyl-CoA delta-isomerase activity;enoyl-CoA hydratase activity;enzyme binding;long-chain-enoyl-CoA hydratase activity;receptor binding","cytosol;mitochondrion;peroxisomal matrix;peroxisome","beta-Alanine metabolism;Butanoate metabolism;Carbon metabolism;Fatty acid degradation;Fatty acid metabolism;Lysine degradation;Metabolic pathways;Peroxisome;PPAR signaling pathway;Propanoate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,2,2,2,"3.5","3.5","3.5","79.494",0,"3.5708",30027000,10,"0.18725","0.833355","0.28372","0.528816","sp|Q08426|ECHP_HUMAN","sp|Q08426|ECHP_HUMAN",1475,"Q08426","ECHP_HUMAN","Peroxisomal bifunctional enzyme","BE;BFE","EHHADH"]
["13.9962","13.945","14.3389","13.0353",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular response to UV;embryonic digit morphogenesis;histone acetylation;homeostatic process;negative regulation of transcription from RNA polymerase II promoter;Notch signaling pathway;N-terminal peptidyl-lysine acetylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;protein acetylation;protein complex assembly;protein destabilization;regulation of apoptotic process;regulation of cellular response to heat;regulation of lipid metabolic process;regulation of myeloid cell differentiation;regulation of smoothened signaling pathway;regulation of transcription from RNA polymerase II promoter in response to hypoxia;regulation of transcription, DNA-templated;response to hypoxia;rhythmic process;signal transduction;stimulatory C-type lectin receptor signaling pathway;transcription initiation from RNA polymerase II promoter;viral process","acetyltransferase activity;chromatin binding;damaged DNA binding;DNA binding transcription factor activity;histone acetyltransferase activity;MRF binding;p53 binding;peptide N-acetyltransferase activity;proximal promoter sequence-specific DNA binding;RNA polymerase II activating transcription factor binding;RNA polymerase II transcription coactivator activity;RNA polymerase II transcription factor binding;signal transducer activity;transcription coactivator activity;transcription factor binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription factor binding;zinc ion binding","cytoplasm;histone acetyltransferase complex;nuclear body;nuclear chromatin;nucleoplasm;nucleus","Adherens junction;cAMP signaling pathway;Cell cycle;FoxO signaling pathway;Glucagon signaling pathway;Hepatitis B;HIF-1 signaling pathway;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term potentiation;Melanogenesis;MicroRNAs in cancer;Notch signaling pathway;Pathways in cancer;Prostate cancer;Renal cell carcinoma;TGF-beta signaling pathway;Thyroid hormone signaling pathway;Tuberculosis;Viral carcinogenesis;Wnt signaling pathway",null,null,1,1,1,"0.7","0.7","0.7","265.35","0.00040177","3.4005",10321000,4,"0.15103","0.875793","0.283484","0.434568","sp|Q92793|CBP_HUMAN","sp|Q92793|CBP_HUMAN",2191,"Q92793","CBP_HUMAN","CREB-binding protein",null,"CREBBP"]
["15.7856","15.2714","15.8668","14.6276",{"$nulls":3},"cellular zinc ion homeostasis;negative regulation of B cell apoptotic process;positive regulation of B cell proliferation;positive regulation of B cell receptor signaling pathway;positive regulation of protein tyrosine phosphatase activity;zinc II ion transmembrane import","zinc ion transmembrane transporter activity","integral component of plasma membrane",{"$nulls":3},1,1,1,"3.9","3.9","3.9","94.131",0,"5.7225",6456100,3,"0.145255","0.878613","0.281298","0.419329","sp|Q9ULF5|S39AA_HUMAN","sp|Q9ULF5|S39AA_HUMAN",2891,"Q9ULF5","S39AA_HUMAN","Zinc transporter ZIP10",null,"SLC39A10"]
["16.0805","17.024","15.9347","16.6096",{"$nulls":3},"actin cytoskeleton reorganization;actomyosin structure organization;cell migration;cytoskeleton organization;establishment or maintenance of cell polarity;intracellular signal transduction;protein phosphorylation;signal transduction","ATP binding;magnesium ion binding;protein kinase activity;protein serine/threonine kinase activity;Rho GTPase binding","actomyosin;cell leading edge;cell-cell junction;cytoplasm;cytoskeleton;extracellular exosome;lamellipodium;plasma membrane",{"$nulls":3},2,2,2,"1.8","1.8","1.8","194.31",0,"35.619",59957000,4,"0.169477","0.850889","0.280055","0.482832","sp|Q9Y5S2|MRCKB_HUMAN","sp|Q9Y5S2|MRCKB_HUMAN",3026,"Q9Y5S2","MRCKB_HUMAN","Serine/threonine-protein kinase MRCK beta",null,"CDC42BPB"]
[1,"21.7713",1,"21.214",{"$nulls":5},"nuclear body;nuclear membrane;nucleolus;nucleus",{"$nulls":3},1,1,1,"27.6","27.6","27.6","6.6846",0,"13.725",18036000,1,"0.00594494","0.988871","0.278659","0.0192287","tr|B8ZZJ0|B8ZZJ0_HUMAN;tr|B9A032|B9A032_HUMAN;sp|P63165|SUMO1_HUMAN;tr|B8ZZN6|B8ZZN6_HUMAN","tr|B8ZZJ0|B8ZZJ0_HUMAN;tr|B9A032|B9A032_HUMAN;sp|P63165|SUMO1_HUMAN;tr|B8ZZN6|B8ZZN6_HUMAN",1343,"B8ZZJ0","B8ZZJ0_HUMAN",null,null,"SUMO1"]
["15.4134","15.1352","15.4273","14.5664",{"$nulls":3},"brain development;cell cycle arrest;cellular response to DNA damage stimulus;cellular response to gamma radiation;cellular response to nitrosative stress;cellular response to X-ray;determination of adult lifespan;DNA damage induced protein phosphorylation;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA double-strand break processing;DNA repair;DNA replication;DNA synthesis involved in DNA repair;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;establishment of macromolecular complex localization to telomere;establishment of RNA localization to telomere;female meiotic nuclear division;heart development;histone mRNA catabolic process;histone phosphorylation;immunoglobulin production;intrinsic apoptotic signaling pathway in response to DNA damage;lipoprotein catabolic process;male meiotic nuclear division;meiotic telomere clustering;mitotic spindle assembly checkpoint;multicellular organism growth;negative regulation of B cell proliferation;negative regulation of telomere capping;negative regulation of TORC1 signaling;neuron apoptotic process;oocyte development;ovarian follicle development;peptidyl-serine autophosphorylation;peptidyl-serine phosphorylation;positive regulation of apoptotic process;positive regulation of DNA catabolic process;positive regulation of DNA damage response, signal transduction by p53 class mediator;positive regulation of histone phosphorylation;positive regulation of neuron apoptotic process;positive regulation of telomerase catalytic core complex assembly;positive regulation of telomere maintenance via telomerase;positive regulation of telomere maintenance via telomere lengthening;post-embryonic development;pre-B cell allelic exclusion;protein autophosphorylation;protein phosphorylation;reciprocal meiotic recombination;regulation of apoptotic process;regulation of autophagy;regulation of cellular response to gamma radiation;regulation of cellular response to heat;regulation of microglial cell activation;regulation of signal transduction by p53 class mediator;regulation of telomere maintenance via telomerase;replicative senescence;response to hypoxia;response to ionizing radiation;signal transduction;signal transduction involved in mitotic G2 DNA damage checkpoint;somitogenesis;strand displacement;telomere maintenance;thymus development;V(D)J recombination","1-phosphatidylinositol-3-kinase activity;ATP binding;DNA binding;DNA-dependent protein kinase activity;lipid transporter activity;protein complex binding;protein dimerization activity;protein N-terminus binding;protein serine/threonine kinase activity","cytoplasmic vesicle;DNA repair complex;nucleolus;nucleoplasm;nucleus;spindle","Apoptosis;Cell cycle;Cellular senescence;FoxO signaling pathway;Homologous recombination;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;MicroRNAs in cancer;NF-kappa B signaling pathway;p53 signaling pathway;Platinum drug resistance;Transcriptional misregulation in cancer",null,null,2,2,2,1,1,1,"350.68",0,"12.431",43527000,2,"0.220366","0.801412","0.277513","0.613449","sp|Q13315|ATM_HUMAN","sp|Q13315|ATM_HUMAN",1543,"Q13315","ATM_HUMAN","Serine-protein kinase ATM",null,"ATM"]
["19.8374","19.7413","19.3366","19.6917",{"$nulls":3},"proteolysis",null,"proteasome regulatory particle",{"$nulls":3},7,7,7,"27.5","27.5","27.5","32.551",0,"11.133",137920000,24,"0.56347","0.470074","0.275199","1.49634","tr|R4GMR5|R4GMR5_HUMAN;sp|P48556|PSMD8_HUMAN;tr|K7EJR3|K7EJR3_HUMAN;tr|K7ENY6|K7ENY6_HUMAN;tr|K7EJC1|K7EJC1_HUMAN;tr|K7ERW6|K7ERW6_HUMAN","tr|R4GMR5|R4GMR5_HUMAN;sp|P48556|PSMD8_HUMAN;tr|K7EJR3|K7EJR3_HUMAN",1055,"R4GMR5","R4GMR5_HUMAN",null,null,"PSMD8"]
["19.0889","18.4358","19.0984","17.8783",{"$nulls":4},"actin binding;structural molecule activity","cell junction;cytoskeleton;nucleus;plasma membrane",{"$nulls":3},9,9,9,"11.6","11.6","11.6","104.36",0,"106.57",209500000,30,"0.136464","0.892547","0.274001","0.395999","tr|E9PHY5|E9PHY5_HUMAN;sp|O43491|E41L2_HUMAN;tr|E9PK52|E9PK52_HUMAN;tr|I6L9B1|I6L9B1_HUMAN;tr|Q6R5J7|Q6R5J7_HUMAN;tr|E9PII3|E9PII3_HUMAN;tr|E9PJP4|E9PJP4_HUMAN;tr|E9PQN0|E9PQN0_HUMAN;tr|E9PRG1|E9PRG1_HUMAN;tr|E9PIG0|E9PIG0_HUMAN;tr|E9PQD2|E9PQD2_HUMAN;tr|Q6ZSX4|Q6ZSX4_HUMAN;tr|E9PMG5|E9PMG5_HUMAN;tr|E9PN54|E9PN54_HUMAN;tr|E9PMV8|E9PMV8_HUMAN;tr|H0Y5B0|H0Y5B0_HUMAN","tr|E9PHY5|E9PHY5_HUMAN;sp|O43491|E41L2_HUMAN;tr|E9PK52|E9PK52_HUMAN;tr|I6L9B1|I6L9B1_HUMAN",3090,"E9PHY5","E9PHY5_HUMAN",null,null,"EPB41L2"]
["17.4603","18.5347","17.3917","18.0579",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"11.8","11.8","11.8","61.024",0,"6.6045",64566000,10,"0.14984","0.876238","0.272701","0.431435","sp|Q7Z5L9|I2BP2_HUMAN","sp|Q7Z5L9|I2BP2_HUMAN",1960,"Q7Z5L9","I2BP2_HUMAN","Interferon regulatory factor 2-binding protein 2","RF-2-binding protein 2;RF-2BP2","IRF2BP2"]
["24.1635","24.014","24.112","23.5246",{"$nulls":3},"camera-type eye development;cellular protein metabolic process;in utero embryonic development;post-translational protein modification","calcium ion binding","endoplasmic reticulum;endoplasmic reticulum lumen",{"$nulls":3},9,9,9,"41.1","41.1","41.1","38.89",0,"323.31",2487100000,74,"0.331283","0.70195","0.270478","0.892372","sp|Q15293|RCN1_HUMAN;tr|E9PP27|E9PP27_HUMAN","sp|Q15293|RCN1_HUMAN",1690,"Q15293","RCN1_HUMAN","Reticulocalbin-1",null,"RCN1"]
["19.8424","19.7774","20.0808","18.9989",{"$nulls":3},"glycosaminoglycan metabolic process","N-acetylglucosamine-6-sulfatase activity","lysosome",{"$nulls":3},2,2,2,"6.9","6.9","6.9","34.608","0.0011186","2.7735",85685000,5,"0.175418","0.845765","0.270017","0.498255","tr|H0YFA9|H0YFA9_HUMAN;tr|H7C3P4|H7C3P4_HUMAN;sp|P15586|GNS_HUMAN;tr|F6S8M0|F6S8M0_HUMAN;tr|F5H4C6|F5H4C6_HUMAN","tr|H0YFA9|H0YFA9_HUMAN;tr|H7C3P4|H7C3P4_HUMAN;sp|P15586|GNS_HUMAN;tr|F6S8M0|F6S8M0_HUMAN;tr|F5H4C6|F5H4C6_HUMAN",688,"H0YFA9","H0YFA9_HUMAN",null,null,"GNS"]
["16.546","17.1079","17.4022","15.7135",{"$nulls":3},"lysosome localization",null,"BORC complex;lysosomal membrane",{"$nulls":3},1,1,1,"4.2","4.2","4.2","37.226",0,"20.351",16663000,5,"0.101874","0.913947","0.26907","0.302384","sp|Q96GS4|CQ059_HUMAN","sp|Q96GS4|CQ059_HUMAN",2283,"Q96GS4","BORC6_HUMAN","BLOC-1-related complex subunit 6 {ECO:0000305}",null,"BORCS6"]
["23.0168","22.9787","22.7799","22.6781",{"$nulls":3},"carbohydrate metabolic process;protein folding","carbohydrate binding;glucan 1,3-alpha-glucosidase activity;RNA binding","endoplasmic reticulum lumen;extracellular exosome;extracellular matrix;glucosidase II complex;Golgi apparatus;melanosome;membrane","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,18,18,18,"23.2","23.2","23.2","106.87",0,"323.31",3430600000,113,"1.41386","0.330394","0.268672","4.94402","sp|Q14697|GANAB_HUMAN;tr|F5H6X6|F5H6X6_HUMAN;tr|E9PKU7|E9PKU7_HUMAN;tr|E9PNH1|E9PNH1_HUMAN","sp|Q14697|GANAB_HUMAN;tr|F5H6X6|F5H6X6_HUMAN;tr|E9PKU7|E9PKU7_HUMAN",1641,"Q14697","GANAB_HUMAN","Neutral alpha-glucosidase AB",null,"GANAB"]
["19.2815","19.2562","19.7025","18.3066",{"$nulls":3},"endocytosis;intracellular protein transport;negative regulation of epidermal growth factor-activated receptor activity;negative regulation of transcription, DNA-templated;negative regulation of transforming growth factor beta receptor signaling pathway;regulation of macroautophagy;retrograde transport, endosome to Golgi;vesicle organization","dynactin binding;phosphatidylinositol binding;protein heterodimerization activity;protein homodimerization activity","cytoplasm;cytosol;early endosome membrane;extrinsic component of membrane;intracellular;nucleus;retromer complex;retromer, tubulation complex;tubular endosome","Endocytosis",null,null,2,2,2,"5.2","5.2","5.2","46.648","0.006004","1.8617",136990000,5,"0.129964","0.898859","0.264312","0.378638","sp|Q9UNH7|SNX6_HUMAN;tr|A0A0A0MRI2|A0A0A0MRI2_HUMAN;tr|G3V5X9|G3V5X9_HUMAN","sp|Q9UNH7|SNX6_HUMAN;tr|A0A0A0MRI2|A0A0A0MRI2_HUMAN;tr|G3V5X9|G3V5X9_HUMAN",2911,"Q9UNH7","SNX6_HUMAN","Sorting nexin-6",null,"SNX6"]
["19.913","19.6947","20.5042","18.5757",{"$nulls":9},1,1,1,"21.3","21.3","21.3","11.545",0,"54.443",56457000,9,"0.0909077","0.920627","0.26394","0.271993","tr|M0QY17|M0QY17_HUMAN;tr|M0R3F4|M0R3F4_HUMAN;tr|M0R2A4|M0R2A4_HUMAN;tr|M0R2K3|M0R2K3_HUMAN;tr|M0R193|M0R193_HUMAN;tr|M0R0I0|M0R0I0_HUMAN;tr|M0R2I2|M0R2I2_HUMAN;tr|J3KQS6|J3KQS6_HUMAN;sp|Q9NWV8|BABA1_HUMAN","tr|M0QY17|M0QY17_HUMAN;tr|M0R3F4|M0R3F4_HUMAN;tr|M0R2A4|M0R2A4_HUMAN;tr|M0R2K3|M0R2K3_HUMAN;tr|M0R193|M0R193_HUMAN;tr|M0R0I0|M0R0I0_HUMAN;tr|M0R2I2|M0R2I2_HUMAN;tr|J3KQS6|J3KQS6_HUMAN;sp|Q9NWV8|BABA1_HUMAN",2730,"M0QY17","M0QXG9_HUMAN",null,null,"BABAM1"]
["18.8182","18.4151","18.7578","17.9489",{"$nulls":3},"activation of MAPKK activity;cellular response to amino acid starvation;defense response to virus;endoplasmic reticulum unfolded protein response;evasion or tolerance by virus of host immune response;innate immune response;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of osteoblast proliferation;negative regulation of translation;negative regulation of viral genome replication;positive regulation of chemokine production;positive regulation of cytokine production;positive regulation of NF-kappaB transcription factor activity;positive regulation of NIK/NF-kappaB signaling;positive regulation of stress-activated MAPK cascade;protein autophosphorylation;protein phosphorylation;regulation of hematopoietic progenitor cell differentiation;regulation of hematopoietic stem cell differentiation;regulation of hematopoietic stem cell proliferation;regulation of NLRP3 inflammasome complex assembly;response to interferon-alpha;response to toxic substance;response to virus;transcription, DNA-templated;translation","ATP binding;double-stranded RNA binding;eukaryotic translation initiation factor 2alpha kinase activity;identical protein binding;non-membrane spanning protein tyrosine kinase activity;protein kinase activity;protein phosphatase regulator activity;protein serine/threonine kinase activity;RNA binding","cytoplasm;cytosol;membrane;nucleus;perinuclear region of cytoplasm;ribosome","Epstein-Barr virus infection;Hepatitis C;Herpes simplex virus 1 infection;Human papillomavirus infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;Necroptosis;Protein processing in endoplasmic reticulum;Viral carcinogenesis",null,null,3,3,3,"6.7","6.7","6.7","62.094",0,"8.979",66605000,14,"0.208246","0.815717","0.263251","0.582611","sp|P19525|E2AK2_HUMAN;tr|F8WBH4|F8WBH4_HUMAN;tr|C9JZT2|C9JZT2_HUMAN","sp|P19525|E2AK2_HUMAN",733,"P19525","E2AK2_HUMAN","Interferon-induced, double-stranded RNA-activated protein kinase",null,"EIF2AK2"]
["18.2752","18.3225","18.5198","17.5519",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitinyl hydrolase activity",{"$nulls":4},8,8,8,"11.3","11.3","11.3","105.55",0,"28.707",140970000,23,"0.192663","0.830042","0.262977","0.542735","tr|H3BND8|H3BND8_HUMAN;sp|Q93009|UBP7_HUMAN;tr|F5H2X1|F5H2X1_HUMAN;tr|H3BUV0|H3BUV0_HUMAN;tr|H3BTM1|H3BTM1_HUMAN;tr|H3BRA2|H3BRA2_HUMAN;tr|H3BQD1|H3BQD1_HUMAN","tr|H3BND8|H3BND8_HUMAN;sp|Q93009|UBP7_HUMAN;tr|F5H2X1|F5H2X1_HUMAN",2213,"H3BND8","H3BND8_HUMAN",null,null,"USP7"]
["21.177","21.0399","21.0113","20.6819",{"$nulls":3},"acrosome assembly;actin cytoskeleton organization;adult locomotory behavior;ameboidal-type cell migration;auditory receptor cell development;brain morphogenesis;cerebral cortex development;cerebral cortex neuron differentiation;chemical synaptic transmission;ciliary basal body-plasma membrane docking;cochlea development;corpus callosum morphogenesis;cortical microtubule organization;establishment of centrosome localization;establishment of mitotic spindle orientation;establishment of planar polarity of embryonic epithelium;G2/M transition of mitotic cell cycle;germ cell development;hippocampus development;layer formation in cerebral cortex;learning or memory;lipid catabolic process;maintenance of centrosome location;microtubule cytoskeleton organization;microtubule cytoskeleton organization involved in establishment of planar polarity;microtubule organizing center organization;microtubule-based process;negative regulation of JNK cascade;negative regulation of neuron projection development;neuroblast proliferation;neuromuscular process controlling balance;neuron migration;nuclear envelope disassembly;nuclear migration;osteoclast development;platelet activating factor metabolic process;positive regulation of axon extension;positive regulation of cytokine-mediated signaling pathway;positive regulation of dendritic spine morphogenesis;positive regulation of embryonic development;positive regulation of mitotic cell cycle;protein secretion;regulation of G2/M transition of mitotic cell cycle;regulation of GTPase activity;regulation of microtubule cytoskeleton organization;regulation of microtubule motor activity;retrograde axonal transport;sister chromatid cohesion;stem cell division;transmission of nerve impulse;vesicle transport along microtubule","dynactin binding;dynein complex binding;dynein intermediate chain binding;heparin binding;microtubule binding;phospholipase A2 activity;phospholipase binding;phosphoprotein binding;protein homodimerization activity","astral microtubule;axon cytoplasm;cell cortex;cell leading edge;central region of growth cone;centrosome;cytosol;extracellular exosome;kinesin complex;kinetochore;microtubule associated complex;motile cilium;neuronal cell body;nuclear envelope;nuclear membrane;perinuclear region of cytoplasm;stereocilium","Ether lipid metabolism;Metabolic pathways",null,null,4,4,4,"13.2","13.2","13.2","46.637",0,"49.536",582450000,21,"0.552999","0.475775","0.261837","1.46768","sp|P43034|LIS1_HUMAN;tr|I3L495|I3L495_HUMAN;tr|I3L3N5|I3L3N5_HUMAN","sp|P43034|LIS1_HUMAN",1002,"P43034","LIS1_HUMAN","Platelet-activating factor acetylhydrolase IB subunit alpha {ECO:0000255|HAMAP-Rule:MF_03141}",null,"PAFAH1B1"]
["20.9555","20.8537","19.88","21.4064",{"$nulls":3},"autophagy;axonogenesis;cellular response to insulin stimulus;ciliary basal body-plasma membrane docking;cilium assembly;G2/M transition of mitotic cell cycle;Golgi vesicle fusion to target membrane;neurotransmitter receptor transport to postsynaptic membrane;post-translational protein modification;protein localization to plasma membrane;protein secretion;regulation of autophagy;regulation of exocytosis;regulation of long-term neuronal synaptic plasticity;regulation of protein transport;vesicle docking involved in exocytosis","GDP binding;GTP binding;GTPase activity;myosin V binding;protein kinase binding;Rab GTPase binding","centriole;centrosome;ciliary basal body;ciliary base;cilium;cytosol;dendritic spine;extracellular exosome;extracellular matrix;Golgi membrane;neuronal cell body;non-motile cilium;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane;postsynaptic density;recycling endosome membrane;secretory granule membrane;synaptic vesicle;trans-Golgi network membrane;trans-Golgi network transport vesicle","AMPK signaling pathway;Endocytosis;Pancreatic secretion;Tight junction",null,null,3,2,2,"15.9","12.6","12.6","23.668",0,"16.354",304730000,14,"0.116257","0.904436","0.261374","0.341693","sp|P61006|RAB8A_HUMAN;tr|H0YMN7|H0YMN7_HUMAN","sp|P61006|RAB8A_HUMAN",1249,"P61006","RAB8A_HUMAN","Ras-related protein Rab-8A",null,"RAB8A"]
["18.3567","18.2716","17.3708","18.7391",{"$nulls":4},"GTP binding",{"$nulls":4},1,1,1,"4.7","4.7","4.7","26.422","0.000755","2.8527",34395000,1,"0.129799","0.898674","0.259244","0.378197","sp|Q5HYI8|RABL3_HUMAN","sp|Q5HYI8|RABL3_HUMAN",1808,"Q5HYI8","RABL3_HUMAN","Rab-like protein 3",null,"RABL3"]
["20.6583","21.3027","21.1791","20.2635",{"$nulls":3},"aromatic compound catabolic process;epoxide metabolic process;response to organic cyclic compound;response to toxic substance;xenobiotic metabolic process","cis-stilbene-oxide hydrolase activity;epoxide hydrolase activity","endoplasmic reticulum membrane;integral component of membrane;organelle membrane","Bile secretion;Chemical carcinogenesis;Metabolism of xenobiotics by cytochrome P450",null,null,7,7,7,"16.7","16.7","16.7","52.948",0,"35.188",556500000,21,"0.161886","0.86309","0.25921","0.463044","sp|P07099|HYEP_HUMAN;tr|B1AQP8|B1AQP8_HUMAN;tr|B1AQP9|B1AQP9_HUMAN","sp|P07099|HYEP_HUMAN",538,"P07099","HYEP_HUMAN","Epoxide hydrolase 1",null,"EPHX1"]
["21.0352","20.7276","20.8148","20.4303",{"$nulls":3},"blood circulation;cholesterol biosynthetic process;L-ascorbic acid metabolic process;neutrophil degranulation;xenobiotic metabolic process","ADP binding;AMP binding;cytochrome-b5 reductase activity, acting on NAD(P)H;FAD binding;flavin adenine dinucleotide binding;NAD binding;oxidoreductase activity","azurophil granule lumen;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;extracellular region;hemoglobin complex;lipid droplet;membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion","Amino sugar and nucleotide sugar metabolism",null,null,6,6,6,"27.2","27.2","27.2","34.234",0,"9.4289",257020000,14,"0.394278","0.62371","0.258845","1.05135","sp|P00387|NB5R3_HUMAN;tr|B1AHF3|B1AHF3_HUMAN","sp|P00387|NB5R3_HUMAN;tr|B1AHF3|B1AHF3_HUMAN",465,"P00387","NB5R3_HUMAN","NADH-cytochrome b5 reductase 3","5R;ytochrome b5 reductase","CYB5R3"]
["18.2008","18.2658","18.3988","17.5504",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","proteasome binding;thiol-dependent ubiquitin-specific protease activity","Ino80 complex",{"$nulls":3},2,2,2,"12.8","12.8","12.8","29.116",0,"6.4701",51837000,14,"0.218235","0.801882","0.258666","0.608037","tr|Q5LJB0|Q5LJB0_HUMAN;sp|Q9Y5K5|UCHL5_HUMAN;tr|Q5LJA5|Q5LJA5_HUMAN;tr|Q5LJA9|Q5LJA9_HUMAN","tr|Q5LJB0|Q5LJB0_HUMAN;sp|Q9Y5K5|UCHL5_HUMAN;tr|Q5LJA5|Q5LJA5_HUMAN;tr|Q5LJA9|Q5LJA9_HUMAN",3017,"Q5LJB0","Q5LJB0_HUMAN","Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU361215}",null,"UCHL5"]
["15.5742","16.2213","15.6392","15.6394",{"$nulls":3},"fatty acid beta-oxidation","acyl-CoA oxidase activity;FAD binding","intracellular membrane-bounded organelle;mitochondrion;peroxisome",{"$nulls":3},1,1,1,"1.5","1.5","1.5","75.141","0.00039093","3.1711",11073000,4,"0.293911","0.73636","0.25841","0.79865","tr|C9J0G0|C9J0G0_HUMAN;sp|Q99424|ACOX2_HUMAN","tr|C9J0G0|C9J0G0_HUMAN;sp|Q99424|ACOX2_HUMAN",2367,"C9J0G0","C9J0G0_HUMAN","Acyl-coenzyme A oxidase {ECO:0000256|PIRNR:PIRNR000168}",null,"ACOX2"]
["21.9171","21.8894","22.0912","21.1989",{"$nulls":9},4,4,4,"38.6","38.6","38.6","17.27",0,"11.461",224320000,19,"0.206591","0.816271","0.258191","0.578387","sp|Q96K17|BT3L4_HUMAN;tr|E9PL10|E9PL10_HUMAN","sp|Q96K17|BT3L4_HUMAN;tr|E9PL10|E9PL10_HUMAN",2311,"Q96K17","BT3L4_HUMAN","Transcription factor BTF3 homolog 4",null,"BTF3L4"]
["22.8094","22.5546","22.8062","22.0425",{"$nulls":4},"actin binding","cytoskeleton;fibrillar center;plasma membrane",{"$nulls":3},21,16,15,"36.5",28,"26.6","69.371",0,"161.09",2239400000,81,"0.23087","0.792408","0.257664","0.640075","tr|E7EQR4|E7EQR4_HUMAN;sp|P15311|EZRI_HUMAN;tr|E9PQ82|E9PQ82_HUMAN;tr|E9PNV3|E9PNV3_HUMAN","tr|E7EQR4|E7EQR4_HUMAN;sp|P15311|EZRI_HUMAN",682,"E7EQR4","E7EQR4_HUMAN",null,null,"EZR"]
["21.876","20.8708","21.2174","21.0147",{"$nulls":3},"branched-chain amino acid catabolic process;valine catabolic process","3-hydroxyisobutyrate dehydrogenase activity;NAD binding;phosphogluconate dehydrogenase (decarboxylating) activity","mitochondrial matrix","Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,5,5,5,22,22,22,"35.329",0,"11.528",249050000,25,"0.176827","0.842804","0.257343","0.501905","sp|P31937|3HIDH_HUMAN;tr|H7BZL2|H7BZL2_HUMAN","sp|P31937|3HIDH_HUMAN;tr|H7BZL2|H7BZL2_HUMAN",892,"P31937","3HIDH_HUMAN","3-hydroxyisobutyrate dehydrogenase, mitochondrial","IBADH","HIBADH"]
["13.1531","13.6594","13.7624","12.5509",{"$nulls":5},"cytosol;Golgi apparatus;intracellular membrane-bounded organelle",{"$nulls":3},2,2,2,"1.6","1.6","1.6","246.6",0,"3.7575",14521000,6,"0.130564","0.899071","0.249633","0.380244","tr|H0Y6I0|H0Y6I0_HUMAN;sp|Q13439|GOGA4_HUMAN;tr|A0A087WTW2|A0A087WTW2_HUMAN;tr|E7EVX2|E7EVX2_HUMAN","tr|H0Y6I0|H0Y6I0_HUMAN;sp|Q13439|GOGA4_HUMAN;tr|A0A087WTW2|A0A087WTW2_HUMAN;tr|E7EVX2|E7EVX2_HUMAN",1555,"H0Y6I0","H0Y6I0_HUMAN",null,null,"GOLGA4"]
["15.3881","15.6178","15.8456","14.6636",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;transcription from RNA polymerase III promoter;transcription initiation from RNA polymerase III promoter;transcription, DNA-templated;tRNA transcription from RNA polymerase III promoter","DNA binding;enzyme activator activity;histone acetyltransferase activity","mitochondrion;nucleoplasm;nucleus;transcription factor TFIIIC complex",{"$nulls":3},2,2,2,"5.2","5.2","5.2","91.981",0,"3.9672",21811000,5,"0.142671","0.883378","0.248331","0.412489","sp|Q9UKN8|TF3C4_HUMAN","sp|Q9UKN8|TF3C4_HUMAN",2874,"Q9UKN8","TF3C4_HUMAN","General transcription factor 3C polypeptide 4",null,"GTF3C4"]
["17.1898","17.2652","16.6748","17.2851",{"$nulls":3},"negative regulation of oxidative stress-induced neuron death",null,"cytoplasm;lysosomal membrane;membrane",{"$nulls":3},2,2,2,"6.1","6.1","6.1","50.993",0,"3.6524",27730000,9,"0.296473","0.733076","0.247534","0.805073","sp|Q6P9B6|TLDC1_HUMAN","sp|Q6P9B6|TLDC1_HUMAN",1890,"Q6P9B6","TLDC1_HUMAN","TLD domain-containing protein 1",null,"TLDC1"]
["16.9509","16.3961","16.3655","16.4929",{"$nulls":3},"ciliary basal body-plasma membrane docking;cytoplasmic microtubule organization;G2/M transition of mitotic cell cycle;meiotic spindle organization;microtubule cytoskeleton organization;microtubule nucleation;regulation of G2/M transition of mitotic cell cycle","GTP binding;GTPase activity;identical protein binding;structural constituent of cytoskeleton","apical part of cell;cell leading edge;centriole;centrosome;ciliary basal body;condensed nuclear chromosome;cytoplasm;cytoplasmic microtubule;cytosol;gamma-tubulin complex;non-motile cilium;pericentriolar material;polar microtubule;recycling endosome","Human papillomavirus infection",null,null,2,2,2,"12.9","12.9","12.9","51.169",0,"8.6581",22057000,5,"0.317754","0.71251","0.244328","0.858426","sp|P23258|TBG1_HUMAN;tr|K7EKE5|K7EKE5_HUMAN;tr|K7EIS0|K7EIS0_HUMAN;sp|Q9NRH3|TBG2_HUMAN","sp|P23258|TBG1_HUMAN;tr|K7EKE5|K7EKE5_HUMAN;tr|K7EIS0|K7EIS0_HUMAN;sp|Q9NRH3|TBG2_HUMAN",774,"P23258","TBG1_HUMAN","Tubulin gamma-1 chain",null,"TUBG1"]
["19.5377","19.7969","19.4628","19.3839",{"$nulls":4},"catalytic activity",{"$nulls":4},1,1,1,"21.1","21.1","21.1","7.5734",0,"5.5797",24475000,3,"0.670479","0.387055","0.243959","1.80063","tr|F8WCL3|F8WCL3_HUMAN;tr|F8WBU3|F8WBU3_HUMAN;tr|H7C2M1|H7C2M1_HUMAN;tr|C9JNL5|C9JNL5_HUMAN;tr|H7C4A1|H7C4A1_HUMAN;sp|Q96I15|SCLY_HUMAN;tr|A0A0A0MQU4|A0A0A0MQU4_HUMAN","tr|F8WCL3|F8WCL3_HUMAN;tr|F8WBU3|F8WBU3_HUMAN;tr|H7C2M1|H7C2M1_HUMAN;tr|C9JNL5|C9JNL5_HUMAN;tr|H7C4A1|H7C4A1_HUMAN;sp|Q96I15|SCLY_HUMAN;tr|A0A0A0MQU4|A0A0A0MQU4_HUMAN",2292,"F8WCL3","F8WCL3_HUMAN",null,null,"SCLY"]
["26.3095","25.9162","26.0434","25.6945",{"$nulls":4},"DNA binding","nucleus",{"$nulls":3},6,6,5,"36.1","36.1","28.5","18.311",0,"98.938",3273800000,107,"0.345335","0.689602","0.243906","0.927681","tr|Q5T7C4|Q5T7C4_HUMAN;sp|P09429|HMGB1_HUMAN;sp|B2RPK0|HGB1A_HUMAN","tr|Q5T7C4|Q5T7C4_HUMAN;sp|P09429|HMGB1_HUMAN;sp|B2RPK0|HGB1A_HUMAN",583,"Q5T7C4","Q5T7C4_HUMAN",null,null,"HMGB1"]
["18.8076","18.8896","19.4005","17.8119",{"$nulls":3},"protein folding;protein import into mitochondrial matrix","adenyl-nucleotide exchange factor activity;chaperone binding;protein homodimerization activity;unfolded protein binding","mitochondrial matrix;mitochondrion;nucleus;presequence translocase-associated import motor",{"$nulls":3},2,2,2,"11.5","11.5","11.5","24.279",0,"9.8525",56119000,10,"0.102758","0.913811","0.242435","0.304818","sp|Q9HAV7|GRPE1_HUMAN","sp|Q9HAV7|GRPE1_HUMAN",2631,"Q9HAV7","GRPE1_HUMAN","GrpE protein homolog 1, mitochondrial",null,"GRPEL1"]
["20.8008","20.8526","20.8805","20.2893",{"$nulls":3},"cell division;G2/M transition of mitotic cell cycle;mitotic cell cycle;negative regulation of protein dephosphorylation;regulation of insulin secretion;response to glucose;response to nutrient;transport","ion channel inhibitor activity;phosphatase inhibitor activity;potassium channel inhibitor activity;protein phosphatase 2A binding;protein phosphatase inhibitor activity;protein phosphatase regulator activity;receptor binding","cytoplasm;nucleoplasm",{"$nulls":3},3,3,2,"30.6","30.6","21.5","13.389",0,"31.215",133830000,13,"0.300444","0.729484","0.241838","0.815029","sp|O43768|ENSA_HUMAN;tr|A6NMQ3|A6NMQ3_HUMAN;tr|Q5T5H1|Q5T5H1_HUMAN","sp|O43768|ENSA_HUMAN;tr|A6NMQ3|A6NMQ3_HUMAN;tr|Q5T5H1|Q5T5H1_HUMAN",265,"O43768","ENSA_HUMAN","Alpha-endosulfine",null,"ENSA"]
["17.3119","17.4158","17.8496","16.3972",{"$nulls":3},"metabolic process","uridylyltransferase activity",{"$nulls":4},11,1,1,"58.5","6.1","6.1","24.235","0.00075443","2.8524",9957400,1,"0.112079","0.904226","0.240502","0.330335","tr|C9JNZ1|C9JNZ1_HUMAN;tr|C9JVG3|C9JVG3_HUMAN;tr|C9JWG0|C9JWG0_HUMAN;tr|C9JTZ5|C9JTZ5_HUMAN;tr|C9JUW1|C9JUW1_HUMAN;tr|F2Z3H1|F2Z3H1_HUMAN;tr|C9J3M0|C9J3M0_HUMAN;tr|F2Z3P4|F2Z3P4_HUMAN;tr|F8WC70|F8WC70_HUMAN","tr|C9JNZ1|C9JNZ1_HUMAN;tr|C9JVG3|C9JVG3_HUMAN;tr|C9JWG0|C9JWG0_HUMAN;tr|C9JTZ5|C9JTZ5_HUMAN;tr|C9JUW1|C9JUW1_HUMAN",3077,"C9JNZ1","C9JNZ1_HUMAN",null,null,"UGP2"]
["15.5013","15.9938","15.8871","15.1272",{"$nulls":3},"nuclear export;protein transport;ribosome biogenesis","GTP binding;GTPase activity","Cajal body;cytosol;endoplasmic reticulum;membrane;nuclear body;nucleus","Ribosome biogenesis in eukaryotes",null,null,1,1,1,"2.9","2.9","2.9","75.225",0,"21.7",18518000,9,"0.188057","0.831625","0.240386","0.530895","sp|Q9H089|LSG1_HUMAN","sp|Q9H089|LSG1_HUMAN",2551,"Q9H089","LSG1_HUMAN","Large subunit GTPase 1 homolog","Lsg1","LSG1"]
["20.3823","20.6382","20.5628","19.983",{"$nulls":3},"2-oxoglutarate metabolic process;cellular nitrogen compound metabolic process;cerebellar cortex development;generation of precursor metabolites and energy;glycolytic process;hippocampus development;lysine catabolic process;NADH metabolic process;olfactory bulb mitral cell layer development;pyramidal neuron development;striatum development;succinyl-CoA metabolic process;tangential migration from the subventricular zone to the olfactory bulb;thalamus development;tricarboxylic acid cycle","chaperone binding;heat shock protein binding;metal ion binding;oxoglutarate dehydrogenase (NAD+) activity;oxoglutarate dehydrogenase (succinyl-transferring) activity;thiamine pyrophosphate binding","mitochondrial matrix;mitochondrial membrane;mitochondrion;oxoglutarate dehydrogenase complex","Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways",null,null,16,16,16,"19.7","19.7","19.7","115.93",0,"61.918",622370000,65,"0.274084","0.755151","0.237327","0.748922","sp|Q02218|ODO1_HUMAN;tr|A0A0D9SFS3|A0A0D9SFS3_HUMAN;tr|E9PDF2|E9PDF2_HUMAN;tr|E9PCR7|E9PCR7_HUMAN;tr|E9PFG7|E9PFG7_HUMAN;tr|C9J4G7|C9J4G7_HUMAN;sp|Q9ULD0|OGDHL_HUMAN","sp|Q02218|ODO1_HUMAN;tr|A0A0D9SFS3|A0A0D9SFS3_HUMAN;tr|E9PDF2|E9PDF2_HUMAN;tr|E9PCR7|E9PCR7_HUMAN;tr|E9PFG7|E9PFG7_HUMAN",1426,"Q02218","ODO1_HUMAN","2-oxoglutarate dehydrogenase, mitochondrial",null,"OGDH"]
["16.6131","16.9049","17.2404","15.8075",{"$nulls":3},"asymmetric cell division;centrosome cycle;COPII vesicle coating;ER to Golgi vesicle-mediated transport;Golgi disassembly;Golgi ribbon formation;microtubule nucleation;mitotic spindle assembly;negative regulation of autophagy;negative regulation of protein binding;positive regulation of protein glycosylation;positive regulation of ubiquitin protein ligase activity;protein glycosylation;protein homotetramerization;spindle assembly;spindle assembly involved in meiosis","cadherin binding;importin-alpha family protein binding;microtubule binding;protein kinase binding;syntaxin binding","cis-Golgi network;COPII-coated ER to Golgi transport vesicle;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus;Golgi cis cisterna;Golgi cisterna membrane;Golgi membrane;microtubule;mitotic spindle;nucleus;spindle pole",{"$nulls":3},2,2,2,"3.7","3.7","3.7","111.66",0,"36.511",64408000,14,"0.108828","0.909591","0.235046","0.321464","tr|A0A0C4DGS5|A0A0C4DGS5_HUMAN;sp|Q08379|GOGA2_HUMAN","tr|A0A0C4DGS5|A0A0C4DGS5_HUMAN;sp|Q08379|GOGA2_HUMAN",1473,"A0A0C4DGS5","GOGA2_HUMAN","Golgin subfamily A member 2",null,"GOLGA2"]
["25.9391","26.0795","25.8484","25.7004",{"$nulls":3},"nucleosome assembly",null,"nucleus",{"$nulls":3},5,5,5,"24.8","24.8","24.8","31.124",0,"323.31",4747700000,50,"0.830126","0.31445","0.234918","2.30276","tr|A0A0C4DFV9|A0A0C4DFV9_HUMAN;sp|Q01105|SET_HUMAN;tr|A0A087X027|A0A087X027_HUMAN;sp|P0DME0|SETLP_HUMAN","tr|A0A0C4DFV9|A0A0C4DFV9_HUMAN;sp|Q01105|SET_HUMAN;tr|A0A087X027|A0A087X027_HUMAN;sp|P0DME0|SETLP_HUMAN",1413,"A0A0C4DFV9","A0A0C4DFV9_HUMAN",null,null,"SET"]
["18.5905","18.7962","18.7757","18.1447",{"$nulls":4},"methyltransferase activity",{"$nulls":4},1,1,1,10,10,10,"14.918",0,"5.2371",26235000,5,"0.255645","0.768429","0.23315","0.702583","tr|F8VP53|F8VP53_HUMAN;tr|F8VVW7|F8VVW7_HUMAN;tr|F8VVX6|F8VVX6_HUMAN;sp|Q5HYK3|COQ5_HUMAN","tr|F8VP53|F8VP53_HUMAN;tr|F8VVW7|F8VVW7_HUMAN;tr|F8VVX6|F8VVX6_HUMAN;sp|Q5HYK3|COQ5_HUMAN",1809,"F8VP53","F8VP53_HUMAN",null,null,"COQ5"]
["24.3125","24.1562","24.4723","23.5315",{"$nulls":4},"Rho GDP-dissociation inhibitor activity","cytoplasm",{"$nulls":3},7,7,7,44,44,44,"21.517",0,"152.86",1389100000,28,"0.171256","0.850235","0.232456","0.487458","tr|J3KTF8|J3KTF8_HUMAN;sp|P52565|GDIR1_HUMAN;tr|J3QQX2|J3QQX2_HUMAN;tr|J3KRE2|J3KRE2_HUMAN;tr|J3KRY1|J3KRY1_HUMAN;tr|J3KS60|J3KS60_HUMAN","tr|J3KTF8|J3KTF8_HUMAN;sp|P52565|GDIR1_HUMAN;tr|J3QQX2|J3QQX2_HUMAN;tr|J3KRE2|J3KRE2_HUMAN;tr|J3KRY1|J3KRY1_HUMAN",1158,"J3KTF8","J3KTF8_HUMAN",null,null,"ARHGDIA"]
["19.1951","19.5464","19.6257","18.6561",{"$nulls":3},"chromatin remodeling;chromosome segregation;circadian regulation of gene expression;circadian rhythm;DNA replication;DNA topological change;embryonic cleavage;peptidyl-serine phosphorylation;phosphorylation;programmed cell death;protein sumoylation;response to drug;viral process","ATP binding;chromatin binding;core promoter sequence-specific DNA binding;DNA binding;DNA topoisomerase type I activity;double-stranded DNA binding;protein domain specific binding;protein serine/threonine kinase activity;RNA binding;single-stranded DNA binding;supercoiled DNA binding","DNA topoisomerase complex (ATP-hydrolyzing);fibrillar center;nucleolus;nucleoplasm;nucleus;P-body;perikaryon;protein-DNA complex;replication fork protection complex",{"$nulls":3},3,3,3,"5.6","5.6","5.6","90.725",0,"16.521",164260000,14,"0.155265","0.871371","0.22983","0.445704","sp|P11387|TOP1_HUMAN","sp|P11387|TOP1_HUMAN",630,"P11387","TOP1_HUMAN","DNA topoisomerase 1",null,"TOP1"]
["17.3176","17.031","18.2362","15.6529",{"$nulls":3},"protein folding in endoplasmic reticulum",null,"ER membrane protein complex;integral component of membrane",{"$nulls":3},2,2,2,"11.9","11.9","11.9","29.952",0,"6.3376",23580000,5,"0.0575197","0.945999","0.229764","0.176796","sp|Q9P0I2|EMC3_HUMAN;tr|S4R3U9|S4R3U9_HUMAN","sp|Q9P0I2|EMC3_HUMAN;tr|S4R3U9|S4R3U9_HUMAN",2770,"Q9P0I2","EMC3_HUMAN","ER membrane protein complex subunit 3",null,"EMC3"]
["21.0689","20.768","21.6801","19.7013",{"$nulls":3},"cell proliferation;cellular heat acclimation;CENP-A containing nucleosome assembly;DNA replication;multicellular organism development;negative regulation of cell growth;negative regulation of G0 to G1 transition;negative regulation of gene expression, epigenetic;negative regulation of transcription from RNA polymerase II promoter;post-translational protein modification;regulation of signal transduction by p53 class mediator;response to steroid hormone;transcription, DNA-templated","histone deacetylase activity;RNA binding","cytosol;ESC/E(Z) complex;nucleoplasm;nucleus;NuRD complex",{"$nulls":3},7,7,5,"23.3","23.3","20.2","47.82",0,"31.916",389980000,23,"0.0751519","0.93041","0.227786","0.227609","sp|Q16576|RBBP7_HUMAN;tr|Q5JP01|Q5JP01_HUMAN;tr|E9PC52|E9PC52_HUMAN;tr|C9J7L0|C9J7L0_HUMAN;tr|Q5JNZ6|Q5JNZ6_HUMAN","sp|Q16576|RBBP7_HUMAN;tr|Q5JP01|Q5JP01_HUMAN;tr|E9PC52|E9PC52_HUMAN",1745,"Q16576","RBBP7_HUMAN","Histone-binding protein RBBP7",null,"RBBP7"]
["20.8285","20.8459","21.054","20.1655",{"$nulls":3},"adenosine salvage;AMP salvage;dATP biosynthetic process;purine-containing compound salvage;ribonucleoside monophosphate biosynthetic process","adenosine kinase activity;ATP binding;metal ion binding;RNA binding","cytosol;nucleoplasm;nucleus","Metabolic pathways;Purine metabolism",null,null,4,4,4,"13.8","13.8","13.8","40.545",0,"53.371",333110000,19,"0.180713","0.837952","0.227485","0.511955","sp|P55263|ADK_HUMAN","sp|P55263|ADK_HUMAN",1209,"P55263","ADK_HUMAN","Adenosine kinase","K","ADK"]
["22.5919","22.3852","22.6063","21.9213",{"$nulls":3},"diphosphate metabolic process;phosphate-containing compound metabolic process;tRNA aminoacylation for protein translation","inorganic diphosphatase activity;magnesium ion binding","cytoplasm;cytosol;extracellular exosome","Oxidative phosphorylation",null,null,9,9,9,"42.2","42.2","42.2","32.66",0,"62.944",1004200000,53,"0.226175","0.796554","0.224727","0.628185","sp|Q15181|IPYR_HUMAN;tr|Q5SQT6|Q5SQT6_HUMAN","sp|Q15181|IPYR_HUMAN;tr|Q5SQT6|Q5SQT6_HUMAN",1682,"Q15181","IPYR_HUMAN","Inorganic pyrophosphatase",null,"PPA1"]
["20.3237","20.1634","20.1451","19.893",{"$nulls":3},"aging;apoptotic mitochondrial changes;cellular response to fibroblast growth factor stimulus;cellular response to follicle-stimulating hormone stimulus;cellular response to glucose stimulus;cellular response to hepatocyte growth factor stimulus;cellular response to leukemia inhibitory factor;cellular response to thyroxine stimulus;cysteine metabolic process;glutamate metabolic process;glutathione biosynthetic process;hepatic stellate cell activation;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of neuron apoptotic process;positive regulation of glutamate-cysteine ligase activity;regulation of blood vessel size;regulation of mitochondrial depolarization;response to activity;response to drug;response to human chorionic gonadotropin;response to nitrosative stress;response to nutrient;response to oxidative stress","enzyme regulator activity;glutamate-cysteine ligase activity;glutamate-cysteine ligase catalytic subunit binding;protein heterodimerization activity","cytosol;glutamate-cysteine ligase complex","Cysteine and methionine metabolism;Ferroptosis;Glutathione metabolism;Metabolic pathways",null,null,3,3,3,"13.9","13.9","13.9","30.727",0,"16.869",115190000,24,"0.565864","0.469802","0.224505","1.50291","sp|P48507|GSH0_HUMAN","sp|P48507|GSH0_HUMAN",1054,"P48507","GSH0_HUMAN","Glutamate--cysteine ligase regulatory subunit",null,"GCLM"]
["17.8804","16.9485","17.7569","16.6239",{"$nulls":3},"positive regulation of cell motility;regulation of transcription, DNA-templated;rRNA transcription;termination of RNA polymerase I transcription;transcription initiation from RNA polymerase I promoter","identical protein binding;RNA binding;rRNA primary transcript binding","caveola;cytoplasm;cytosol;endoplasmic reticulum;intracellular membrane-bounded organelle;membrane raft;mitochondrion;nucleoplasm;nucleus;plasma membrane;protein complex",{"$nulls":3},4,4,4,"19.2","19.2","19.2","43.476",0,"44.763",62493000,14,"0.103019","0.914542","0.224112","0.305535","sp|Q6NZI2|PTRF_HUMAN","sp|Q6NZI2|PTRF_HUMAN",1879,"Q6NZI2","CAVN1_HUMAN","Caveolae-associated protein 1 {ECO:0000312|HGNC:HGNC:9688}",null,"CAVIN1"]
["19.417","18.8529","19.1324","18.6897",{"$nulls":3},"cellular response to stimulus;hippocampus development;negative regulation of translational initiation in response to stress;oligodendrocyte development;response to glucose;response to heat;response to peptide hormone;translational initiation","guanyl-nucleotide exchange factor activity;nucleotidyltransferase activity;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex","Herpes simplex virus 1 infection;RNA transport",null,null,3,3,3,"7.1","7.1","7.1","50.24",0,"36.086",119440000,11,"0.224763","0.796834","0.22392","0.624606","sp|Q9NR50|EI2BG_HUMAN;tr|H0Y580|H0Y580_HUMAN","sp|Q9NR50|EI2BG_HUMAN",2681,"Q9NR50","EI2BG_HUMAN","Translation initiation factor eIF-2B subunit gamma",null,"EIF2B3"]
["20.1132","19.728","19.5166","19.8771",{"$nulls":3},"pyruvate metabolic process","dihydrolipoyllysine-residue acetyltransferase activity","mitochondrial matrix;mitochondrion;pyruvate dehydrogenase complex",{"$nulls":3},4,4,4,"14.2","14.2","14.2","51.201",0,"24.144",239510000,33,"0.313596","0.714076","0.223728","0.848","tr|H0YDD4|H0YDD4_HUMAN;tr|E9PEJ4|E9PEJ4_HUMAN;sp|P10515|ODP2_HUMAN","tr|H0YDD4|H0YDD4_HUMAN;tr|E9PEJ4|E9PEJ4_HUMAN;sp|P10515|ODP2_HUMAN",607,"H0YDD4","H0YDD4_HUMAN","Acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU361137}",null,"DLAT"]
["22.4632","22.1118","22.4566","21.6722",{"$nulls":3},"cellular nitrogen compound metabolic process;generation of precursor metabolites and energy;L-lysine catabolic process to acetyl-CoA via saccharopine;lysine catabolic process;tricarboxylic acid cycle","dihydrolipoyllysine-residue succinyltransferase activity","extracellular exosome;membrane;mitochondrial matrix;myelin sheath;nucleus;oxoglutarate dehydrogenase complex","Carbon metabolism;Citrate cycle (TCA cycle);Lysine degradation;Metabolic pathways;Tryptophan metabolism",null,null,9,9,9,"30.2","30.2","30.2","48.755",0,"121.77",1050300000,63,"0.18354","0.832184","0.223151","0.519255","sp|P36957|ODO2_HUMAN;tr|Q86SW4|Q86SW4_HUMAN;tr|H0YJF9|H0YJF9_HUMAN;tr|G3V5M3|G3V5M3_HUMAN;tr|G3V3F0|G3V3F0_HUMAN","sp|P36957|ODO2_HUMAN;tr|Q86SW4|Q86SW4_HUMAN",951,"P36957","ODO2_HUMAN","Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial",null,"DLST"]
["17.8317","17.5323","18.2082","16.7149",{"$nulls":3},"innate immune response;toll-like receptor signaling pathway","receptor binding","endoplasmic reticulum lumen",{"$nulls":3},1,1,1,"6.8","6.8","6.8","30.748",0,"5.7701",25859000,9,"0.0971879","0.916558","0.220419","0.289445","sp|Q9BT09|CNPY3_HUMAN","sp|Q9BT09|CNPY3_HUMAN",2440,"Q9BT09","CNPY3_HUMAN","Protein canopy homolog 3",null,"CNPY3"]
["20.3002","20.0908","19.7077","20.25",{"$nulls":4},"pyridoxal phosphate binding","cytoplasm;extracellular exosome;intracellular;mitochondrion",{"$nulls":3},3,3,3,"14.2","14.2","14.2","30.344",0,"6.3787",140760000,6,"0.272633","0.75507","0.216639","0.745278","sp|O94903|PROSC_HUMAN;tr|E5RFX7|E5RFX7_HUMAN;tr|H0YBG2|H0YBG2_HUMAN;tr|E5RG77|E5RG77_HUMAN","sp|O94903|PROSC_HUMAN;tr|E5RFX7|E5RFX7_HUMAN",398,"O94903","PLPHP_HUMAN","Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225}","LP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225}"]
["21.4555","21.4841","21.4666","21.0411",{"$nulls":3},"regulation of phosphoprotein phosphatase activity;regulation of signal transduction","protein phosphatase inhibitor activity","cytosol;nucleoplasm",{"$nulls":3},4,4,4,"32.4","32.4","32.4","19.245",0,"12.639",183260000,9,"0.379133","0.643729","0.21596","1.01294","tr|E7EMN6|E7EMN6_HUMAN;sp|P41236|IPP2_HUMAN;sp|Q6NXS1|IPP2M_HUMAN;tr|E7EUI7|E7EUI7_HUMAN","tr|E7EMN6|E7EMN6_HUMAN;sp|P41236|IPP2_HUMAN;sp|Q6NXS1|IPP2M_HUMAN;tr|E7EUI7|E7EUI7_HUMAN",983,"E7EMN6","E7EMN6_HUMAN",null,null,"PPP1R2"]
["18.0874","18.3008","18.3823","17.5744",{"$nulls":5},"cytosol;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},11,11,11,"23.4","23.4","23.4","90.856",0,"26.582",139030000,20,"0.182437","0.835348","0.215765","0.51641","tr|A0A087WT45|A0A087WT45_HUMAN;sp|Q4V328|GRAP1_HUMAN;tr|A0A075B793|A0A075B793_HUMAN;tr|A0A087WXA6|A0A087WXA6_HUMAN;tr|A0A087WW92|A0A087WW92_HUMAN","tr|A0A087WT45|A0A087WT45_HUMAN;sp|Q4V328|GRAP1_HUMAN;tr|A0A075B793|A0A075B793_HUMAN",1789,"A0A087WT45","A0A087WT45_HUMAN",null,null,"GRIPAP1"]
[1,"14.2922",1,"13.8613",{"$nulls":3},"embryo development;in utero embryonic development;olfactory behavior;sensory perception of smell;suckling behavior;ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process via the N-end rule pathway","ubiquitin protein ligase activity;ubiquitin-protein transferase activity;zinc ion binding","cytoplasm;integral component of membrane;ubiquitin ligase complex",{"$nulls":3},1,1,1,"0.7","0.7","0.7","212.43","0.0003885","3.1112",4208700,1,"0.00721414","0.986389","0.215485","0.0233009","sp|Q6ZT12|UBR3_HUMAN","sp|Q6ZT12|UBR3_HUMAN",1919,"Q6ZT12","UBR3_HUMAN","E3 ubiquitin-protein ligase UBR3",null,"UBR3"]
["15.1718","15.2307","15.327","14.6494",{"$nulls":3},"metabolic process","hydrolase activity",{"$nulls":4},1,1,1,"2.3","2.3","2.3","80.464","0.0078689","1.736",7994900,1,"0.225528","0.796199","0.213068","0.626544","tr|F8W1I9|F8W1I9_HUMAN;sp|Q6JQN1|ACD10_HUMAN","tr|F8W1I9|F8W1I9_HUMAN;sp|Q6JQN1|ACD10_HUMAN",1872,"F8W1I9","F8W1I9_HUMAN",null,null,"ACAD10"]
["18.1933","18.1086","18.2147","17.6687",{"$nulls":3},"animal organ regeneration;liver development;membrane organization;neutrophil degranulation;positive regulation of apoptotic process;post-embryonic development;receptor-mediated endocytosis;response to retinoic acid;signal transduction;spermatogenesis","enzyme binding;G-protein alpha-subunit binding;G-protein coupled receptor activity;identical protein binding;insulin-like growth factor II binding;insulin-like growth factor-activated receptor activity;mannose binding;phosphoprotein binding;receptor activity;retinoic acid binding","cell surface;clathrin coat;clathrin-coated vesicle membrane;early endosome;endocytic vesicle;endosome;extracellular exosome;focal adhesion;Golgi apparatus;integral component of plasma membrane;late endosome;lysosomal membrane;membrane;nuclear envelope lumen;perinuclear region of cytoplasm;plasma membrane;secretory granule membrane;trans-Golgi network;trans-Golgi network membrane;trans-Golgi network transport vesicle;transport vesicle","Endocytosis;Lysosome",null,null,10,10,10,6,6,6,"274.37",0,"88.529",276410000,32,"0.277394","0.753098","0.209192","0.757228","sp|P11717|MPRI_HUMAN","sp|P11717|MPRI_HUMAN",635,"P11717","MPRI_HUMAN","Cation-independent mannose-6-phosphate receptor","6PR;I Man-6-P receptor;I-MPR","IGF2R"]
["18.3896","18.2754","18.5837","17.6642",{"$nulls":3},"RNA processing","ATP binding;RNA binding;RNA-3'-phosphate cyclase activity","nucleoplasm;nucleus",{"$nulls":3},2,2,2,"7.1","7.1","7.1","39.336","0.0011025","2.6563",65475000,5,"0.156931","0.868719","0.208514","0.450073","sp|O00442|RTCA_HUMAN;tr|A6NIC1|A6NIC1_HUMAN","sp|O00442|RTCA_HUMAN;tr|A6NIC1|A6NIC1_HUMAN",142,"O00442","RTCA_HUMAN","RNA 3'-terminal phosphate cyclase","NA cyclase;NA-3'-phosphate cyclase","RTCA"]
["18.7799","18.267","18.9319","17.7019",{"$nulls":3},"establishment of integrated proviral latency;mRNA 5'-splice site recognition;nuclear transport;positive regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;response to heat;response to oxidative stress;transcription, DNA-templated","activating transcription factor binding;chromatin binding;RNA binding;RNA polymerase II transcription coactivator activity;supercoiled DNA binding","cytosol;nuclear heterochromatin;nuclear periphery;nucleoplasm;nucleus;transcriptionally active chromatin",{"$nulls":3},5,4,4,"12.3","10.8","10.8","60.103",0,"24.417",79879000,12,"0.104605","0.91298","0.206491","0.309896","sp|O75475|PSIP1_HUMAN;tr|H3BPQ6|H3BPQ6_HUMAN;tr|M0R0J3|M0R0J3_HUMAN;tr|A0A024R216|A0A024R216_HUMAN;sp|Q9Y3E1|HDGR3_HUMAN","sp|O75475|PSIP1_HUMAN",347,"O75475","PSIP1_HUMAN","PC4 and SFRS1-interacting protein",null,"PSIP1"]
["20.2462","20.2879","20.6668","19.4544",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;mitochondrial respiratory chain complex III assembly;oxidation-reduction process;oxidative phosphorylation",null,"mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrial respiratory chain complex III","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,2,2,2,"21.6","21.6","21.6","13.53",0,"4.4032",64117000,9,"0.115774","0.903558","0.206473","0.340383","sp|P14927|QCR7_HUMAN;tr|E5RHG9|E5RHG9_HUMAN;tr|B7Z2R2|B7Z2R2_HUMAN","sp|P14927|QCR7_HUMAN;tr|E5RHG9|E5RHG9_HUMAN;tr|B7Z2R2|B7Z2R2_HUMAN",679,"P14927","QCR7_HUMAN","Cytochrome b-c1 complex subunit 7",null,"UQCRB"]
["20.0039","19.8466","19.4741","19.9692",{"$nulls":5},"cytosol",{"$nulls":3},3,3,3,"14.8","14.8","14.8","28.956","0.00075557","2.8552",124350000,11,"0.288069","0.743524","0.203623","0.784003","tr|Q5QPM7|Q5QPM7_HUMAN;sp|Q92530|PSMF1_HUMAN;tr|Q5QPM9|Q5QPM9_HUMAN;tr|H0Y555|H0Y555_HUMAN;tr|F5H4Z3|F5H4Z3_HUMAN","tr|Q5QPM7|Q5QPM7_HUMAN;sp|Q92530|PSMF1_HUMAN;tr|Q5QPM9|Q5QPM9_HUMAN",2168,"Q5QPM7","Q5QPM7_HUMAN",null,null,"PSMF1"]
["18.7895","18.8273","18.8073","18.4037",{"$nulls":3},"microtubule anchoring;negative regulation of DNA binding transcription factor activity;negative regulation of protein binding;negative regulation of protein homotetramerization;negative regulation of transcription, DNA-templated;peroxisome organization;peroxisome transport along microtubule;protein complex assembly;protein homooligomerization;protein import into peroxisome matrix;protein import into peroxisome matrix, substrate release;protein import into peroxisome matrix, translocation","beta-tubulin binding;microtubule binding;protein N-terminus binding;receptor binding;transcription corepressor activity","fibrillar center;integral component of membrane;intracellular;membrane;nucleus;peroxisomal importomer complex;peroxisomal membrane;peroxisome;protein complex","Peroxisome",null,null,3,3,3,"16.4","16.4","16.4","41.236",0,"16.056",49489000,9,"0.374571","0.650514","0.202961","1.00139","sp|O75381|PEX14_HUMAN","sp|O75381|PEX14_HUMAN",338,"O75381","PEX14_HUMAN","Peroxisomal membrane protein PEX14",null,"PEX14"]
["18.7356","18.611","18.8442","18.0977",{"$nulls":3},"cellular amino acid metabolic process","identical protein binding;L-serine ammonia-lyase activity;L-threonine ammonia-lyase activity;pyridoxal phosphate binding","extracellular exosome;mitochondrion","Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways;Valine, leucine and isoleucine biosynthesis",null,null,3,3,3,"14.3","14.3","14.3","34.674",0,"4.8791",57725000,6,"0.189576","0.830637","0.202358","0.534803","sp|Q96GA7|SDSL_HUMAN;tr|F8VYZ3|F8VYZ3_HUMAN;tr|H0YID3|H0YID3_HUMAN","sp|Q96GA7|SDSL_HUMAN",2276,"Q96GA7","SDSL_HUMAN","Serine dehydratase-like",null,"SDSL"]
["21.0384","20.9023","20.8111","20.7253",{"$nulls":3},"alanyl-tRNA aminoacylation;cerebellar Purkinje cell layer development;negative regulation of neuron apoptotic process;neuromuscular process controlling balance;tRNA aminoacylation for protein translation;tRNA modification;tRNA processing","alanine-tRNA ligase activity;amino acid binding;aminoacyl-tRNA editing activity;ATP binding;metal ion binding;tRNA binding","cytoplasm;cytosol;extracellular exosome;membrane","Aminoacyl-tRNA biosynthesis",null,null,15,15,15,"20.2","20.2","20.2","106.81",0,"64.167",894440000,51,"0.89121","0.299487","0.202181","2.51365","sp|P49588|SYAC_HUMAN;tr|H3BPK7|H3BPK7_HUMAN","sp|P49588|SYAC_HUMAN",1080,"P49588","SYAC_HUMAN","Alanine--tRNA ligase, cytoplasmic {ECO:0000255|HAMAP-Rule:MF_03133}",null,"AARS"]
["19.9901","21.1178","20.5183","20.1909",{"$nulls":3},"endothelial cell differentiation;multicellular organism development;positive regulation of DNA binding;positive regulation of transcription, DNA-templated;regulation of lipid metabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated","calmodulin binding;RNA binding;sequence-specific DNA binding;transcription coactivator activity","cytoplasm;cytosol;extracellular exosome;intracellular;nucleolus;nucleus",{"$nulls":3},3,3,3,"19.6","19.6","19.6","16.368",0,"17.344",161440000,17,"0.115482","0.903412","0.199389","0.339592","sp|O60869|EDF1_HUMAN","sp|O60869|EDF1_HUMAN",311,"O60869","EDF1_HUMAN","Endothelial differentiation-related factor 1","DF-1","EDF1"]
["21.7677","21.4946","21.8136","21.0531",{"$nulls":3},"immune response","ATP binding;RNA binding;transferase activity","nucleolus;nucleus",{"$nulls":3},7,7,7,"26.1","26.1","26.1","38.91",0,"17.249",432130000,21,"0.172076","0.849762","0.197792","0.489586","tr|B4DY09|B4DY09_HUMAN;sp|Q12905|ILF2_HUMAN;tr|X6R6Z1|X6R6Z1_HUMAN;tr|A0A0A0MRL0|A0A0A0MRL0_HUMAN","tr|B4DY09|B4DY09_HUMAN;sp|Q12905|ILF2_HUMAN",1504,"B4DY09","B4DY09_HUMAN",null,null,"ILF2"]
["20.9232","20.6626","21.2694","19.9385",{"$nulls":3},"glutathione metabolic process;hydrogen sulfide metabolic process;sulfide oxidation, using sulfide:quinone oxidoreductase","iron ion binding;sulfur dioxygenase activity","cytoplasm;mitochondrial matrix;mitochondrion;nucleoplasm","Metabolic pathways;Sulfur metabolism",null,null,3,3,3,"17.3","17.3","17.3","27.873",0,"9.2716",261910000,20,"0.0933112","0.920492","0.188978","0.278687","sp|O95571|ETHE1_HUMAN;tr|M0QXB5|M0QXB5_HUMAN;tr|M0QY80|M0QY80_HUMAN","sp|O95571|ETHE1_HUMAN;tr|M0QXB5|M0QXB5_HUMAN",440,"O95571","ETHE1_HUMAN","Persulfide dioxygenase ETHE1, mitochondrial",null,"ETHE1"]
["18.3632","18.6582","19.2147","17.4288",{"$nulls":3},"inflammatory response;positive regulation of translation;translation;translational initiation;transmembrane transport","ATP binding;ATPase activity;ribosome binding;RNA binding;translation activator activity;translation factor activity, RNA binding","cytoplasm;cytosol;membrane;nuclear envelope;nucleoplasm;polysomal ribosome;ribosome",{"$nulls":3},7,7,7,"14.1","14.1","14.1","95.925",0,"41.97",170670000,30,"0.0685424","0.936307","0.188894","0.208713","sp|Q8NE71|ABCF1_HUMAN;tr|H0YGW7|H0YGW7_HUMAN;tr|Q5STZ8|Q5STZ8_HUMAN;tr|A0A0G2JIC2|A0A0G2JIC2_HUMAN","sp|Q8NE71|ABCF1_HUMAN;tr|H0YGW7|H0YGW7_HUMAN",2092,"Q8NE71","ABCF1_HUMAN","ATP-binding cassette sub-family F member 1",null,"ABCF1"]
["17.299","16.6621","16.7448","16.8451",{"$nulls":9},2,2,2,"20.5","20.5","20.5","23.507",0,"7.7637",18294000,3,"0.205509","0.818431","0.18559","0.575626","tr|C9JEZ4|C9JEZ4_HUMAN;sp|Q9UKI2|BORG2_HUMAN","tr|C9JEZ4|C9JEZ4_HUMAN;sp|Q9UKI2|BORG2_HUMAN",2870,"C9JEZ4","C9JEZ4_HUMAN",null,null,"CDC42EP3"]
["14.6542","14.3053","15.2948","13.2939",{"$nulls":3},"regulation of ion transmembrane transport","voltage-gated ion channel activity;voltage-gated sodium channel activity","voltage-gated sodium channel complex",{"$nulls":3},1,1,1,"0.8","0.8","0.8","221.3","0.00077012","3.016",10868000,5,"0.059506","0.944427","0.185428","0.182586","tr|K4DIA1|K4DIA1_HUMAN;tr|A0A0A0MT39|A0A0A0MT39_HUMAN;tr|E9PHB6|E9PHB6_HUMAN;tr|E9PG18|E9PG18_HUMAN;tr|H9KVD2|H9KVD2_HUMAN;sp|Q14524|SCN5A_HUMAN","tr|K4DIA1|K4DIA1_HUMAN;tr|A0A0A0MT39|A0A0A0MT39_HUMAN;tr|E9PHB6|E9PHB6_HUMAN;tr|E9PG18|E9PG18_HUMAN;tr|H9KVD2|H9KVD2_HUMAN;sp|Q14524|SCN5A_HUMAN",1626,"K4DIA1","K4DIA1_HUMAN","Sodium channel protein {ECO:0000256|RuleBase:RU361132}",null,"SCN5A"]
["22.47","22.5898","22.4812","22.2112",{"$nulls":3},"embryonic camera-type eye development;embryonic eye morphogenesis;face development;Harderian gland development;inner ear morphogenesis;locomotory behavior;neuromuscular process controlling balance;nucleus accumbens development;olfactory pit development;optic cup morphogenesis involved in camera-type eye development;positive regulation of apoptotic process;protein homotetramerization;retinal metabolic process;retinoic acid biosynthetic process;retinoic acid metabolic process;retinol metabolic process;righting reflex","aldehyde dehydrogenase (NAD) activity;aldehyde dehydrogenase [NAD(P)+] activity;NAD+ binding;protein homodimerization activity;retinal dehydrogenase activity;thyroid hormone binding","cytoplasm;cytosol;extracellular exosome;nucleus;plasma membrane","beta-Alanine metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Glycolysis / Gluconeogenesis;Histidine metabolism;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Phenylalanine metabolism;Tyrosine metabolism",null,null,13,13,12,"35.9","35.9","34.2","56.108",0,"85.513",960040000,68,"0.468901","0.534164","0.183668","1.2434","sp|P47895|AL1A3_HUMAN;tr|H0Y2X5|H0Y2X5_HUMAN;tr|H0YNQ3|H0YNQ3_HUMAN;tr|H0YKF9|H0YKF9_HUMAN;tr|H0YLT1|H0YLT1_HUMAN;tr|H0YMG7|H0YMG7_HUMAN;sp|P00352|AL1A1_HUMAN;sp|O94788|AL1A2_HUMAN","sp|P47895|AL1A3_HUMAN;tr|H0Y2X5|H0Y2X5_HUMAN",1046,"P47895","AL1A3_HUMAN","Aldehyde dehydrogenase family 1 member A3",null,"ALDH1A3"]
["16.7283",1,"16.3625",1,{"$nulls":3},"cellular response to retinoic acid;cellular response to transforming growth factor beta stimulus;cellular response to tumor necrosis factor;mRNA processing;mRNA splicing, via spliceosome;negative regulation of chaperone-mediated autophagy;negative regulation of protein refolding;positive regulation of mRNA splicing, via spliceosome;regulation of ATPase activity;regulation of RNA splicing;RNA splicing","mRNA binding;RNA binding;U1 snRNA binding;U1 snRNP binding","commitment complex;cytoplasm;nuclear speck;nucleoplasm;nucleus;precatalytic spliceosome;spliceosomal complex;U1 snRNP;U2-type prespliceosome","Spliceosome",null,null,1,1,1,"4.1","4.1","4.1","51.556","0.0011194","2.7741",11089000,1,"0.0051382","0.990639","0.182861","0.0166343","sp|P08621|RU17_HUMAN","sp|P08621|RU17_HUMAN",566,"P08621","RU17_HUMAN","U1 small nuclear ribonucleoprotein 70 kDa","1 snRNP 70 kDa;1-70K;nRNP70","SNRNP70"]
["19.8474","19.7486","20.2233","19.0142",{"$nulls":3},"cellular response to leukemia inhibitory factor;polyamine metabolic process;spermidine biosynthetic process","identical protein binding;protein homodimerization activity;spermidine synthase activity","cytosol","Arginine and proline metabolism;beta-Alanine metabolism;Cysteine and methionine metabolism;Glutathione metabolism;Metabolic pathways",null,null,3,3,3,"15.6","15.6","15.6","33.824",0,"6.0146",149260000,11,"0.0994087","0.915889","0.179288","0.295586","sp|P19623|SPEE_HUMAN;tr|K7EL89|K7EL89_HUMAN;tr|K7ESL0|K7ESL0_HUMAN","sp|P19623|SPEE_HUMAN;tr|K7EL89|K7EL89_HUMAN",734,"P19623","SPEE_HUMAN","Spermidine synthase","PDSY","SRM"]
["17.0498","16.9855","16.1244","17.5547",{"$nulls":3},"basophil degranulation;endosome organization;Golgi organization;phosphatidylinositol biosynthetic process;phosphatidylinositol phosphorylation","1-phosphatidylinositol 4-kinase activity;AP-3 adaptor complex binding;ATP binding;magnesium ion binding","cell junction;cytoplasmic vesicle;cytosol;dendrite;early endosome membrane;endosome;growing cell tip;host cell presynaptic membrane;integral component of plasma membrane;intrinsic component of membrane;lysosomal membrane;membrane;membrane raft;mitochondrion;neuron projection;neuronal cell body;perikaryon;plasma membrane;presynaptic membrane;protein complex;synaptic vesicle membrane;trans-Golgi network","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,3,3,3,"10.2","10.2","10.2","54.022",0,"3.5232",36283000,6,"0.0826347","0.928267","0.178114","0.248799","sp|Q9BTU6|P4K2A_HUMAN;tr|E9PAM4|E9PAM4_HUMAN","sp|Q9BTU6|P4K2A_HUMAN;tr|E9PAM4|E9PAM4_HUMAN",2449,"Q9BTU6","P4K2A_HUMAN","Phosphatidylinositol 4-kinase type 2-alpha",null,"PI4K2A"]
["20.1311","20.0254","19.8588","19.9421",{"$nulls":3},"macroautophagy;protein import into mitochondrial matrix;protein import into mitochondrial outer membrane;protein targeting to mitochondrion","protein transmembrane transporter activity","integral component of membrane;integral component of mitochondrial outer membrane;membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrial outer membrane translocase complex",{"$nulls":3},2,2,2,"26.1","26.1","26.1","15.521",0,"18.738",57026000,11,"0.927176","0.296861","0.177788","2.64341","sp|Q9NS69|TOM22_HUMAN","sp|Q9NS69|TOM22_HUMAN",2690,"Q9NS69","TOM22_HUMAN","Mitochondrial import receptor subunit TOM22 homolog","Tom22","TOMM22"]
["19.5891","19.7563","19.4342","19.5581",{"$nulls":3},"dendrite morphogenesis;lysosomal transport;lysosome localization;lysosome organization;positive regulation of dendrite development",null,"endosome;extracellular exosome;integral component of membrane;late endosome membrane;lysosomal membrane;lysosome",{"$nulls":3},5,5,5,"24.1","24.1","24.1","31.127",0,"18.377",104000000,13,"0.63489","0.408857","0.176543","1.69695","sp|Q9NUM4|T106B_HUMAN;tr|C9JZ87|C9JZ87_HUMAN;tr|F2Z3N7|F2Z3N7_HUMAN","sp|Q9NUM4|T106B_HUMAN;tr|C9JZ87|C9JZ87_HUMAN;tr|F2Z3N7|F2Z3N7_HUMAN",2706,"Q9NUM4","T106B_HUMAN","Transmembrane protein 106B",null,"TMEM106B"]
["23.1847","23.0627","22.9686","22.9278",{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},7,7,6,"29.6","29.6","26.7","33.155",0,"152.84",1040600000,30,"0.950137","0.296196","0.175514","2.72856","tr|F8W6I7|F8W6I7_HUMAN;sp|P09651|ROA1_HUMAN;sp|Q32P51|RA1L2_HUMAN;tr|F8VTQ5|F8VTQ5_HUMAN;tr|F8VZ49|F8VZ49_HUMAN;tr|F8VYN5|F8VYN5_HUMAN;tr|F8W646|F8W646_HUMAN;tr|H0YH80|H0YH80_HUMAN","tr|F8W6I7|F8W6I7_HUMAN;sp|P09651|ROA1_HUMAN;sp|Q32P51|RA1L2_HUMAN;tr|F8VTQ5|F8VTQ5_HUMAN;tr|F8VZ49|F8VZ49_HUMAN",591,"F8W6I7","F8W6I7_HUMAN",null,null,"HNRNPA1"]
["17.548","17.3584","17.6012","16.9549",{"$nulls":3},"adaptive immune response;angiogenesis;antigen processing and presentation of endogenous peptide antigen via MHC class I;antigen processing and presentation of peptide antigen via MHC class I;cell-cell signaling;fat cell differentiation;membrane protein ectodomain proteolysis;peptide catabolic process;positive regulation of angiogenesis;regulation of blood pressure;regulation of innate immune response;response to bacterium;signal transduction","aminopeptidase activity;endopeptidase activity;interleukin-1, Type II receptor binding;interleukin-6 receptor binding;metalloaminopeptidase activity;metalloexopeptidase activity;peptide binding;zinc ion binding","cytosol;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular exosome;extracellular region;extracellular space;integral component of membrane;membrane;plasma membrane",{"$nulls":3},3,3,3,4,4,4,"107.23",0,"5.7481",75252000,9,"0.183827","0.833012","0.175118","0.519996","sp|Q9NZ08|ERAP1_HUMAN;tr|H0Y9X5|H0Y9X5_HUMAN","sp|Q9NZ08|ERAP1_HUMAN",2754,"Q9NZ08","ERAP1_HUMAN","Endoplasmic reticulum aminopeptidase 1",null,"ERAP1"]
["17.7191","17.6303","17.8446","17.1551",{"$nulls":3},"negative regulation of chromatin binding;negative regulation of transcription from RNA polymerase II promoter;positive regulation of G1/S transition of mitotic cell cycle;RNA methylation;snRNA metabolic process;snRNA modification","RNA binding;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity",{"$nulls":4},1,1,1,"2.8","2.8","2.8","74.354",0,"65.662",40208000,9,"0.177226","0.842704","0.174827","0.502938","sp|Q7L2J0|MEPCE_HUMAN","sp|Q7L2J0|MEPCE_HUMAN",1932,"Q7L2J0","MEPCE_HUMAN","7SK snRNA methylphosphate capping enzyme","ePCE","MEPCE"]
["19.8277","19.8142","19.9632","19.3348",{"$nulls":3},"aging;anatomical structure formation involved in morphogenesis;axon guidance;branching involved in labyrinthine layer morphogenesis;cell differentiation;cell migration;cell-cell signaling;cellular response to ionizing radiation;entry of bacterium into host cell;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;fibroblast growth factor receptor signaling pathway;innate immune response;insulin receptor signaling pathway;interleukin-15-mediated signaling pathway;leukocyte migration;MAPK cascade;membrane organization;negative regulation of epidermal growth factor receptor signaling pathway;peptidyl-tyrosine autophosphorylation;positive regulation of actin filament polymerization;positive regulation of protein kinase B signaling;positive regulation of reactive oxygen species metabolic process;protein heterooligomerization;Ras protein signal transduction;receptor internalization;regulation of cell proliferation;regulation of MAPK cascade;signal transduction in response to DNA damage;T cell costimulation;viral process","1-phosphatidylinositol-3-kinase activity;ephrin receptor binding;epidermal growth factor receptor binding;identical protein binding;insulin receptor substrate binding;neurotrophin TRKA receptor binding;non-membrane spanning protein tyrosine kinase activity;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;phosphotyrosine residue binding;protein kinase binding;protein phosphatase binding;Ras guanyl-nucleotide exchange factor activity;RNA binding;SH3 domain binding;SH3/SH2 adaptor activity","cell-cell junction;COP9 signalosome;cytoplasm;cytosol;endosome;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane;Golgi apparatus;Grb2-EGFR complex;nucleolus;nucleoplasm;nucleus;plasma membrane;vesicle membrane","Acute myeloid leukemia;Alcoholism;B cell receptor signaling pathway;Breast cancer;Chemokine signaling pathway;Choline metabolism in cancer;Chronic myeloid leukemia;Colorectal cancer;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Human cytomegalovirus infection;Human papillomavirus infection;Insulin signaling pathway;Jak-STAT signaling pathway;MAPK signaling pathway;MicroRNAs in cancer;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-small cell lung cancer;Osteoclast differentiation;Pathways in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Ras signaling pathway;Relaxin signaling pathway;Renal cell carcinoma;Signaling pathways regulating pluripotency of stem cells;T cell receptor signaling pathway;Thermogenesis;Viral carcinogenesis",null,null,3,3,3,"15.7","15.7","15.7","25.206",0,"4.4797",127420000,7,"0.19435","0.828349","0.171948","0.547066","sp|P62993|GRB2_HUMAN;tr|J3KT38|J3KT38_HUMAN","sp|P62993|GRB2_HUMAN",1336,"P62993","GRB2_HUMAN","Growth factor receptor-bound protein 2",null,"GRB2"]
["20.7187","20.3771","21.0567","19.7003",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;interferon-gamma-mediated signaling pathway;protection from natural killer cell mediated cytotoxicity;regulation of immune response;type I interferon signaling pathway;viral process","beta-2-microglobulin binding;peptide antigen binding;TAP binding","cell surface;early endosome membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},6,6,2,"24.9","24.9","7.9","40.688",0,"73.072",308350000,34,"0.0802908","0.92809","0.169375","0.242184","sp|P05534|1A24_HUMAN;sp|P30447|1A23_HUMAN;tr|Q5SRN7|Q5SRN7_HUMAN;tr|A0A0G2JI36|A0A0G2JI36_HUMAN;sp|P30455|1A36_HUMAN;sp|P30443|1A01_HUMAN;sp|P16188|1A30_HUMAN;sp|P13746|1A11_HUMAN;sp|P04439|1A03_HUMAN;tr|Q5SRN5|Q5SRN5_HUMAN;tr|A0A0G2JIF2|A0A0G2JIF2_HUMAN;tr|A0A0G2JL56|A0A0G2JL56_HUMAN;tr|Q9GJ45|Q9GJ45_HUMAN;tr|B0UXQ0|B0UXQ0_HUMAN;sp|P30512|1A29_HUMAN;sp|P30459|1A74_HUMAN;sp|P30457|1A66_HUMAN;sp|P30456|1A43_HUMAN;sp|P30453|1A34_HUMAN;sp|P30450|1A26_HUMAN;sp|P18462|1A25_HUMAN;sp|P16190|1A33_HUMAN;sp|P16189|1A31_HUMAN;sp|P10314|1A32_HUMAN;sp|P01891|1A68_HUMAN;sp|Q9TNN7|1C05_HUMAN;tr|A0A0G2JIF0|A0A0G2JIF0_HUMAN;tr|A0A0G2JH50|A0A0G2JH50_HUMAN;tr|A0A0G2JPD3|A0A0G2JPD3_HUMAN;tr|A2BF26|A2BF26_HUMAN;tr|Q31611|Q31611_HUMAN;tr|A0A0G2JNX1|A0A0G2JNX1_HUMAN;tr|Q8MH48|Q8MH48_HUMAN;sp|P17693|HLAG_HUMAN;tr|A0A0G2JNF2|A0A0G2JNF2_HUMAN;tr|Q5RJ85|Q5RJ85_HUMAN;tr|A0A0G2JPQ3|A0A0G2JPQ3_HUMAN;tr|D0EV57|D0EV57_HUMAN;tr|A0A0G2JPA3|A0A0G2JPA3_HUMAN;sp|P30488|1B50_HUMAN;sp|P30487|1B49_HUMAN;sp|P30485|1B47_HUMAN;sp|P30483|1B45_HUMAN;sp|P30481|1B44_HUMAN;sp|P30461|1B13_HUMAN;sp|Q09160|1A80_HUMAN;tr|A0A0G2JH66|A0A0G2JH66_HUMAN","sp|P05534|1A24_HUMAN;sp|P30447|1A23_HUMAN;tr|Q5SRN7|Q5SRN7_HUMAN;tr|A0A0G2JI36|A0A0G2JI36_HUMAN;sp|P30455|1A36_HUMAN;sp|P30443|1A01_HUMAN;sp|P16188|1A30_HUMAN;sp|P13746|1A11_HUMAN;sp|P04439|1A03_HUMAN;tr|Q5SRN5|Q5SRN5_HUMAN;tr|A0A0G2JIF2|A0A0G2JIF2_HUMAN;tr|A0A0G2JL56|A0A0G2JL56_HUMAN",522,"P05534","1A24_HUMAN","HLA class I histocompatibility antigen, A-24 alpha chain",null,"HLA-A"]
["21.2047","21.2318","21.453","20.6466",{"$nulls":5},"nucleus",{"$nulls":3},3,3,3,"27.5","27.5","27.5","11.799",0,"4.8854",154390000,7,"0.144567","0.879976","0.168431","0.417508","tr|F5H6P7|F5H6P7_HUMAN;sp|P61326|MGN_HUMAN;sp|Q96A72|MGN2_HUMAN;tr|F5H3U9|F5H3U9_HUMAN;tr|F5H6N1|F5H6N1_HUMAN","tr|F5H6P7|F5H6P7_HUMAN;sp|P61326|MGN_HUMAN;sp|Q96A72|MGN2_HUMAN;tr|F5H3U9|F5H3U9_HUMAN;tr|F5H6N1|F5H6N1_HUMAN",1270,"F5H6P7","F5H6P7_HUMAN",null,null,"MAGOHB"]
["16.1672",1,"15.8306",1,{"$nulls":3},"cell proliferation;cell surface receptor signaling pathway;cell-cell adhesion;negative regulation of branching involved in ureteric bud morphogenesis;negative regulation of cell motility;negative regulation of epithelial cell migration;negative regulation of ruffle assembly;negative regulation of stress fiber assembly;negative regulation of substrate adhesion-dependent cell spreading;positive regulation of stem cell differentiation;regulation of epithelial cell proliferation;ureteric bud morphogenesis;visual perception","receptor activity","basal plasma membrane;cytosol;extracellular exosome;extracellular space;integral component of plasma membrane;lateral plasma membrane;membrane;nucleus",{"$nulls":3},2,2,2,8,8,8,"35.709",0,"5.5632",9725000,3,"0.00490062","0.990463","0.168319","0.0158694","sp|P09758|TACD2_HUMAN","sp|P09758|TACD2_HUMAN",594,"P09758","TACD2_HUMAN","Tumor-associated calcium signal transducer 2",null,"TACSTD2"]
["17.9331","18.1622","18.4422","17.318",{"$nulls":3},"ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitin-specific protease activity","intracellular",{"$nulls":3},1,1,1,"10.3","10.3","10.3","21.945",0,"40.554",21652000,2,"0.0981378","0.917186","0.167542","0.292073","tr|A0A087WTB8|A0A087WTB8_HUMAN;sp|P15374|UCHL3_HUMAN","tr|A0A087WTB8|A0A087WTB8_HUMAN;sp|P15374|UCHL3_HUMAN",683,"A0A087WTB8","A0A087WTB8_HUMAN","Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU361215}"]
["19.0905","19.141","19.3939","18.503",{"$nulls":4},"zinc ion binding","intracellular",{"$nulls":3},5,5,5,"17.5","17.5","17.5","58.454",0,"16.932",108310000,9,"0.128602","0.898035","0.167313","0.374988","tr|A0A0J9YX34|A0A0J9YX34_HUMAN;sp|Q9C040|TRIM2_HUMAN;tr|C9J084|C9J084_HUMAN;tr|A0A0J9YW70|A0A0J9YW70_HUMAN;tr|C9JVI3|C9JVI3_HUMAN","tr|A0A0J9YX34|A0A0J9YX34_HUMAN;sp|Q9C040|TRIM2_HUMAN",2528,"A0A0J9YX34","A0A0J9YX34_HUMAN",null,null,"TRIM2"]
["20.7163","20.7892","20.697","20.4743",{"$nulls":3},"axonogenesis;cargo loading into vesicle;cell proliferation;clathrin coat assembly;clathrin-dependent endocytosis;dendrite morphogenesis;endosomal transport;hemopoiesis;iron ion homeostasis;iron ion import across plasma membrane;learning or memory;membrane bending;membrane organization;modulation of age-related behavioral decline;negative regulation of gene expression;negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;negative regulation of protein localization to cell surface;negative regulation of protein localization to plasma membrane;negative regulation of receptor-mediated endocytosis;positive regulation of amyloid-beta clearance;positive regulation of amyloid-beta formation;positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;positive regulation of clathrin-dependent endocytosis;positive regulation of GTPase activity;positive regulation of neuron death;positive regulation of transcription, DNA-templated;protein complex assembly;receptor internalization;receptor-mediated endocytosis;regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;regulation of endocytosis;regulation of protein localization;regulation of vesicle size;synaptic vesicle maturation;transcytosis;vesicle organization;vesicle-mediated transport","1-phosphatidylinositol binding;cadherin binding;clathrin adaptor activity;clathrin binding;clathrin heavy chain binding;low-density lipoprotein particle receptor binding;phosphatidylinositol-4,5-bisphosphate binding;Rab GTPase binding","cell surface;clathrin-coated endocytic vesicle;clathrin-coated pit;clathrin-coated vesicle;cytosol;early endosome;endosome to plasma membrane transport vesicle;Golgi apparatus;intracellular membrane-bounded organelle;intrinsic component of membrane;membrane;neurofibrillary tangle;neuronal cell body;nucleus;perinuclear region of cytoplasm;postsynaptic membrane;presynaptic membrane;vesicle",{"$nulls":3},8,8,8,16,16,16,"70.754",0,"92.093",409940000,44,"0.537661","0.49034","0.167093","1.42602","sp|Q13492|PICAL_HUMAN;tr|H0YCY1|H0YCY1_HUMAN;tr|H0YEF7|H0YEF7_HUMAN;tr|H0YEH1|H0YEH1_HUMAN;tr|H0YE97|H0YE97_HUMAN;tr|H0YEY8|H0YEY8_HUMAN;tr|H0YD48|H0YD48_HUMAN;tr|E9PJT1|E9PJT1_HUMAN;tr|E9PK13|E9PK13_HUMAN","sp|Q13492|PICAL_HUMAN;tr|H0YCY1|H0YCY1_HUMAN",1562,"Q13492","PICAL_HUMAN","Phosphatidylinositol-binding clathrin assembly protein",null,"PICALM"]
["19.8299","20.0632","19.3896","20.1715",{"$nulls":3},"carbohydrate metabolic process;glucosamine metabolic process;glucose 1-phosphate metabolic process;hemopoiesis;protein N-linked glycosylation;protein O-linked glycosylation;spermatogenesis;UDP-N-acetylglucosamine biosynthetic process","magnesium ion binding;phosphoacetylglucosamine mutase activity;phosphoglucomutase activity","cytosol","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,8,8,8,"23.1","23.1","23.1","59.851",0,"74.088",297890000,22,"0.140547","0.884976","0.165973","0.406855","sp|O95394|AGM1_HUMAN;tr|A0A087WT27|A0A087WT27_HUMAN;tr|J3KN95|J3KN95_HUMAN;tr|H0Y8I3|H0Y8I3_HUMAN;tr|D6RCQ8|D6RCQ8_HUMAN;tr|D6RF77|D6RF77_HUMAN;tr|H0Y987|H0Y987_HUMAN;tr|D6RIS6|D6RIS6_HUMAN;tr|D6RCD1|D6RCD1_HUMAN;tr|D6RC77|D6RC77_HUMAN","sp|O95394|AGM1_HUMAN;tr|A0A087WT27|A0A087WT27_HUMAN;tr|J3KN95|J3KN95_HUMAN",431,"O95394","AGM1_HUMAN","Phosphoacetylglucosamine mutase {ECO:0000305}","AGM","PGM3"]
["18.3036","17.9911","17.8309","18.137",{"$nulls":4},"RNA binding","intracellular ribonucleoprotein complex;nucleoplasm;viral nucleocapsid",{"$nulls":3},1,1,1,"4.4","4.4","4.4","40.04","0.0010885","2.5236",47347000,7,"0.273393","0.755396","0.163411","0.747185","tr|A0A087WUK2|A0A087WUK2_HUMAN;sp|O14979|HNRDL_HUMAN","tr|A0A087WUK2|A0A087WUK2_HUMAN;sp|O14979|HNRDL_HUMAN",187,"A0A087WUK2","A0A087WUK2_HUMAN",null,null,"HNRNPDL"]
["16.7867","16.5173","16.9447","16.0327",{"$nulls":4},"oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;protein disulfide isomerase activity","endoplasmic reticulum",{"$nulls":3},2,1,1,"16.2","9.8","9.8","19.966","0.0081833","1.7314",10678000,3,"0.116932","0.905096","0.163336","0.343525","tr|Q5TAE8|Q5TAE8_HUMAN;sp|Q86YB8|ERO1B_HUMAN;tr|G3V2H0|G3V2H0_HUMAN","tr|Q5TAE8|Q5TAE8_HUMAN;sp|Q86YB8|ERO1B_HUMAN;tr|G3V2H0|G3V2H0_HUMAN",2001,"Q5TAE8","Q5TAE8_HUMAN",null,null,"ERO1B"]
["24.9566","24.6528","24.6899","24.5969",{"$nulls":3},"defense response to fungus;neutrophil degranulation","actin binding;enzyme binding","cytoskeleton;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleus;secretory granule lumen",{"$nulls":3},9,9,9,"66.2","66.2","66.2","15.945",0,"57.423",2512600000,73,"0.38013","0.641186","0.161301","1.01546","sp|Q14019|COTL1_HUMAN;tr|H3BT58|H3BT58_HUMAN","sp|Q14019|COTL1_HUMAN;tr|H3BT58|H3BT58_HUMAN",1597,"Q14019","COTL1_HUMAN","Coactosin-like protein",null,"COTL1"]
["19.4859","19.3956","19.486","19.0758",{"$nulls":3},"acyl-CoA metabolic process;ketone body biosynthetic process;leucine catabolic process;lipid metabolic process;liver development;mitochondrion organization;protein tetramerization;response to fatty acid;response to nutrient;response to starvation","carboxylic acid binding;fatty-acyl-CoA binding;hydroxymethylglutaryl-CoA lyase activity;magnesium ion binding;manganese ion binding;metal ion binding;protein homodimerization activity;receptor binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrion;peroxisome","Butanoate metabolism;Metabolic pathways;Peroxisome;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation",null,null,2,2,2,"7.4","7.4","7.4","34.36",0,"7.6899",85635000,8,"0.27893","0.751851","0.15983","0.761081","sp|P35914|HMGCL_HUMAN","sp|P35914|HMGCL_HUMAN",940,"P35914","HMGCL_HUMAN","Hydroxymethylglutaryl-CoA lyase, mitochondrial","L;MG-CoA lyase","HMGCL"]
["19.5217","19.406","19.8672","18.7419",{"$nulls":3},"nucleotide-excision repair, DNA damage recognition;post-translational protein modification;protein deneddylation;transcription-coupled nucleotide-excision repair",null,"COP9 signalosome;cytosol;nucleoplasm",{"$nulls":3},3,3,3,"13.5","13.5","13.5","30.276",0,"5.7898",113070000,7,"0.0943922","0.920667","0.159331","0.281692","sp|Q9UBW8|CSN7A_HUMAN;tr|F5H4U8|F5H4U8_HUMAN;tr|F5H7C6|F5H7C6_HUMAN;tr|F5GYF7|F5GYF7_HUMAN;tr|F5H248|F5H248_HUMAN;tr|F5H4Z0|F5H4Z0_HUMAN;tr|F5H3M6|F5H3M6_HUMAN;tr|G3XAP1|G3XAP1_HUMAN;tr|F5GXT7|F5GXT7_HUMAN","sp|Q9UBW8|CSN7A_HUMAN;tr|F5H4U8|F5H4U8_HUMAN;tr|F5H7C6|F5H7C6_HUMAN;tr|F5GYF7|F5GYF7_HUMAN;tr|F5H248|F5H248_HUMAN",2812,"Q9UBW8","CSN7A_HUMAN","COP9 signalosome complex subunit 7a","GN7a;ignalosome subunit 7a","COPS7A"]
["19.2512","19.6344","19.5038","19.0727",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;transcription from RNA polymerase II promoter","identical protein binding;proline-rich region binding;RNA binding;RNA polymerase II repressing transcription factor binding;RNA polymerase II transcription corepressor activity;transcription coactivator activity","nucleoplasm;nucleus","Spliceosome",null,null,5,5,5,"4.4","4.4","4.4","123.9",0,"21.903",192160000,33,"0.190079","0.831062","0.154599","0.536094","sp|O14776|TCRG1_HUMAN;tr|G3V220|G3V220_HUMAN","sp|O14776|TCRG1_HUMAN",173,"O14776","TCRG1_HUMAN","Transcription elongation regulator 1",null,"TCERG1"]
["20.0639","19.73","20.1545","19.331",{"$nulls":3},"activation of MAPKK activity;adenosine receptor signaling pathway;adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;cell cycle;cell division;cell proliferation;gamma-aminobutyric acid signaling pathway;G-protein coupled acetylcholine receptor signaling pathway;G-protein coupled receptor signaling pathway;intracellular signal transduction;negative regulation of adenylate cyclase activity;negative regulation of synaptic transmission;positive regulation of cell proliferation;protein folding;regulation of calcium ion transport;response to nutrient;signal transduction","G-protein beta/gamma-subunit complex binding;G-protein coupled receptor binding;GTP binding;GTPase activity;metal ion binding;signal transducer activity","cell body;centrosome;cytoplasm;cytosol;dendrite;extracellular exosome;extracellular vesicle;heterotrimeric G-protein complex;membrane;membrane raft;midbody;nucleoplasm;plasma membrane","Adrenergic signaling in cardiomyocytes;Alcoholism;Apelin signaling pathway;Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Leukocyte transendothelial migration;Long-term depression;Melanogenesis;Morphine addiction;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Serotonergic synapse;Sphingolipid signaling pathway;Toxoplasmosis",null,null,3,3,2,11,11,"7.9","40.45",0,"13.198",174040000,11,"0.118233","0.904124","0.154196","0.34705","sp|P04899|GNAI2_HUMAN","sp|P04899|GNAI2_HUMAN",505,"P04899","GNAI2_HUMAN","Guanine nucleotide-binding protein G(i) subunit alpha-2",null,"GNAI2"]
["22.066","21.9789","21.9964","21.7402",{"$nulls":3},"cellular protein modification process;protein N-linked glycosylation via asparagine","dolichyl-diphosphooligosaccharide-protein glycotransferase activity;RNA binding","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular matrix;integral component of membrane;melanosome;membrane;oligosaccharyltransferase complex;rough endoplasmic reticulum","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,13,13,13,"26.5","26.5","26.5","68.569",0,"127.84",1495700000,71,"0.428606","0.584799","0.154133","1.13905","sp|P04843|RPN1_HUMAN;tr|B7Z4L4|B7Z4L4_HUMAN;tr|F8WF32|F8WF32_HUMAN","sp|P04843|RPN1_HUMAN;tr|B7Z4L4|B7Z4L4_HUMAN",503,"P04843","RPN1_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1",null,"RPN1"]
["23.3636","23.2676","23.2526","23.073",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process;cellular response to aldosterone;cellular response to estradiol stimulus;cellular response to hydrogen peroxide;cellular response to nitric oxide;cellular response to oxygen-glucose deprivation;chromosome condensation;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;mitochondrial respiratory chain complex I assembly;neuron apoptotic process;neuron differentiation;positive regulation of apoptotic process;positive regulation of neuron apoptotic process;regulation of apoptotic DNA fragmentation;response to ischemia;response to L-glutamate;response to toxic substance","DNA binding;FAD binding;NAD(P)H oxidase activity;oxidoreductase activity, acting on NAD(P)H;protein dimerization activity","cytosol;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrion;nucleus;perinuclear region of cytoplasm","Apoptosis;Necroptosis",null,null,12,12,12,"27.1","27.1","27.1","66.9",0,201,2616900000,86,"0.564988","0.469054","0.152777","1.50051","sp|O95831|AIFM1_HUMAN;tr|E9PMA0|E9PMA0_HUMAN","sp|O95831|AIFM1_HUMAN",453,"O95831","AIFM1_HUMAN","Apoptosis-inducing factor 1, mitochondrial",null,"AIFM1"]
["19.9556","18.0406","20.1534","17.5482",{"$nulls":3},"carbohydrate metabolic process;isocitrate metabolic process;tricarboxylic acid cycle","ATP binding;isocitrate dehydrogenase (NAD+) activity;magnesium ion binding;NAD binding","mitochondrial matrix;mitochondrion;nucleolus;nucleoplasm","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways",null,null,3,3,3,"15.8","15.8","15.8","42.794",0,"20.88",129130000,13,"0.0288661","0.966656","0.147326","0.0911308","sp|P51553|IDH3G_HUMAN;tr|H7C1W2|H7C1W2_HUMAN;tr|E9PF84|E9PF84_HUMAN;tr|G5E9Q7|G5E9Q7_HUMAN;tr|E7EQB8|E7EQB8_HUMAN","sp|P51553|IDH3G_HUMAN;tr|H7C1W2|H7C1W2_HUMAN;tr|E9PF84|E9PF84_HUMAN;tr|G5E9Q7|G5E9Q7_HUMAN;tr|E7EQB8|E7EQB8_HUMAN",1135,"P51553","IDH3G_HUMAN","Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial",null,"IDH3G"]
["20.8179","19.7646","20.7538","19.5345",{"$nulls":3},"cell redox homeostasis;cellular response to oxidative stress;glutathione metabolic process;nucleobase-containing small molecule interconversion","electron transfer activity;flavin adenine dinucleotide binding;glutathione-disulfide reductase activity;NADP binding","cytosol;external side of plasma membrane;extracellular exosome;mitochondrial matrix","Glutathione metabolism;Metabolic pathways;Thyroid hormone synthesis",null,null,9,9,9,"26.8","26.8","26.8","56.256",0,"16.239",324210000,19,"0.0595338","0.94461","0.147161","0.182667","sp|P00390|GSHR_HUMAN;tr|E5RI06|E5RI06_HUMAN;tr|H0YC68|H0YC68_HUMAN","sp|P00390|GSHR_HUMAN",466,"P00390","GSHR_HUMAN","Glutathione reductase, mitochondrial","R;Rase","GSR"]
["23.9179","23.4081","23.7743","23.2628",{"$nulls":3},"apoptotic process;mRNA export from nucleus;nucleocytoplasmic transport;peptidyl-lysine modification to peptidyl-hypusine;positive regulation of cell proliferation;positive regulation of translational elongation;positive regulation of translational termination;protein export from nucleus;translational frameshifting","protein N-terminus binding;ribosome binding;RNA binding;translation elongation factor activity;U6 snRNA binding","annulate lamellae;cytoplasm;cytosol;endoplasmic reticulum membrane;extracellular exosome;membrane;nuclear pore;nucleus",{"$nulls":3},10,10,7,"79.9","79.9","55.8","16.832",0,"323.31",1276500000,70,"0.137919","0.889995","0.144389","0.399872","sp|P63241|IF5A1_HUMAN;tr|I3L397|I3L397_HUMAN;tr|I3L504|I3L504_HUMAN;sp|Q6IS14|IF5AL_HUMAN;tr|F8WCJ1|F8WCJ1_HUMAN;tr|C9J7B5|C9J7B5_HUMAN","sp|P63241|IF5A1_HUMAN;tr|I3L397|I3L397_HUMAN;tr|I3L504|I3L504_HUMAN;sp|Q6IS14|IF5AL_HUMAN",1347,"P63241","IF5A1_HUMAN","Eukaryotic translation initiation factor 5A-1","IF-5A1;IF-5A-1","EIF5A"]
["22.6604","22.7164","23.0563","22.0327",{"$nulls":3},"RNA metabolic process","RNA binding;sequence-specific DNA binding;single-stranded DNA binding",{"$nulls":4},5,5,5,26,26,26,"25.572",0,"36.147",979570000,24,"0.0940635","0.92119","0.143914","0.280778","tr|E9PGT1|E9PGT1_HUMAN;sp|Q15631|TSN_HUMAN;tr|H7C1D4|H7C1D4_HUMAN;tr|A0A0J9YVW2|A0A0J9YVW2_HUMAN","tr|E9PGT1|E9PGT1_HUMAN;sp|Q15631|TSN_HUMAN;tr|H7C1D4|H7C1D4_HUMAN",1708,"E9PGT1","E9PGT1_HUMAN",null,null,"TSN"]
["18.3688","18.2808","18.1858","18.1791",{"$nulls":3},"protein insertion into ER membrane","ATP binding;ATPase activity;metal ion binding","endoplasmic reticulum;nucleolus;nucleus",{"$nulls":3},2,2,2,"10.9","10.9","10.9","37.119","0.0010997","2.6302",55204000,5,"1.07519","0.304952","0.142388","3.22681","tr|A0A087WXS7|A0A087WXS7_HUMAN;sp|O43681|ASNA_HUMAN","tr|A0A087WXS7|A0A087WXS7_HUMAN;sp|O43681|ASNA_HUMAN",257,"A0A087WXS7","A0A087WXS7_HUMAN","ATPase ASNA1 {ECO:0000256|HAMAP-Rule:MF_03112}"]
["22.6483","23.0132","22.9631","22.4149",{"$nulls":3},"adult walking behavior;cellular response to hydroperoxide;negative regulation of neuron apoptotic process;negative regulation of oxidative stress-induced neuron death;negative regulation of peptidyl-cysteine S-nitrosylation;neuron apoptotic process;response to oxidative stress","oxidoreductase activity","mitochondrion;nucleolus",{"$nulls":3},22,22,22,"38.3","38.3","38.3","97.969",0,"323.31",2816600000,151,"0.14947","0.874991","0.141754","0.430459","sp|Q8N573|OXR1_HUMAN;tr|H0YC07|H0YC07_HUMAN;tr|E5RII8|E5RII8_HUMAN;tr|E9PLW2|E9PLW2_HUMAN","sp|Q8N573|OXR1_HUMAN;tr|H0YC07|H0YC07_HUMAN",2054,"Q8N573","OXR1_HUMAN","Oxidation resistance protein 1",null,"OXR1"]
["20.6508","20.7476","21.2134","19.902",{"$nulls":3},"cellular response to menadione;deadenylation-dependent decapping of nuclear-transcribed mRNA;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;mRNA cis splicing, via spliceosome;negative regulation of programmed cell death;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay","exoribonuclease activity;m7G(5')pppN diphosphatase activity;RNA 7-methylguanosine cap binding","cytoplasm;cytosol;mitochondrion;nucleoplasm;nucleus;P-body","RNA degradation",null,null,4,4,4,"16.9","16.9","16.9","38.608",0,"36.465",242270000,31,"0.0708237","0.934863","0.141518","0.215254","sp|Q96C86|DCPS_HUMAN","sp|Q96C86|DCPS_HUMAN",2244,"Q96C86","DCPS_HUMAN","m7GpppX diphosphatase",null,"DCPS"]
["19.6252","18.5376","19.1391","18.7409",{"$nulls":3},"mRNA transport;protein export from nucleus","nuclear export signal receptor activity;Ran GTPase binding","cytoplasm;nuclear pore;nucleus",{"$nulls":3},5,5,5,"4.6","4.6","4.6","123.91",0,"24.87",283040000,12,"0.0809734","0.928427","0.141364","0.244113","sp|Q9UIA9|XPO7_HUMAN;tr|E7ESC6|E7ESC6_HUMAN;tr|H0YBE1|H0YBE1_HUMAN","sp|Q9UIA9|XPO7_HUMAN;tr|E7ESC6|E7ESC6_HUMAN",2848,"Q9UIA9","XPO7_HUMAN","Exportin-7","xp7","XPO7"]
["23.4992","23.9009","24.1547","22.9636",{"$nulls":3},"adult locomotory behavior;negative regulation of peptidase activity;negative regulation of proteolysis;neutrophil degranulation","cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;protease binding;RNA binding","cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;nucleolus;secretory granule lumen;tertiary granule lumen",{"$nulls":3},4,4,4,"58.2","58.2","58.2","11.139",0,"44.948",829720000,28,"0.0739469","0.930885","0.140888","0.224177","sp|P04080|CYTB_HUMAN","sp|P04080|CYTB_HUMAN",491,"P04080","CYTB_HUMAN","Cystatin-B",null,"CSTB"]
["22.0677","21.9863","22.3969","21.3761",{"$nulls":9},7,7,7,"26.8","26.8","26.8","43.036",0,"55.022",780700000,52,"0.0918075","0.920606","0.140541","0.274501","tr|H0Y3Y4|H0Y3Y4_HUMAN;tr|E7ES33|E7ES33_HUMAN;tr|E7EPK1|E7EPK1_HUMAN;sp|Q16181|SEPT7_HUMAN;tr|G3V1Q4|G3V1Q4_HUMAN","tr|H0Y3Y4|H0Y3Y4_HUMAN;tr|E7ES33|E7ES33_HUMAN;tr|E7EPK1|E7EPK1_HUMAN;sp|Q16181|SEPT7_HUMAN;tr|G3V1Q4|G3V1Q4_HUMAN",1731,"H0Y3Y4"]
["17.9451","18.2487","18.6502","17.2633",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;tRNA export from nucleus;viral process;viral transcription","Ran GTPase binding","host cell;intracellular membrane-bounded organelle;nuclear membrane;nuclear pore;nucleoplasm","RNA transport",null,null,3,3,3,"9.2","9.2","9.2","50.144",0,"23.17",90106000,9,"0.0646335","0.936789","0.140172","0.197453","sp|Q9UKX7|NUP50_HUMAN","sp|Q9UKX7|NUP50_HUMAN",2878,"Q9UKX7","NUP50_HUMAN","Nuclear pore complex protein Nup50",null,"NUP50"]
["16.0875","16.0305","16.0504","15.7876",{"$nulls":3},"intracellular signal transduction;regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity","cytosol",{"$nulls":3},1,1,1,"5.7","5.7","5.7","58.309",0,"18.909",10366000,3,"0.390399","0.632369","0.139996","1.0415","sp|Q96QD5|DEPD7_HUMAN;tr|A0A087WW54|A0A087WW54_HUMAN","sp|Q96QD5|DEPD7_HUMAN;tr|A0A087WW54|A0A087WW54_HUMAN",2338,"Q96QD5","DEPD7_HUMAN","DEP domain-containing protein 7",null,"DEPDC7"]
["18.5909","18.0862","17.818","18.5837",{"$nulls":3},"ATP metabolic process;protein folding;proteolysis involved in cellular protein catabolic process","ATP binding;ATPase activity;metal ion binding;peptidase activator activity;unfolded protein binding","cytosol;endopeptidase Clp complex;mitochondrial endopeptidase Clp complex;mitochondrial inner membrane;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleoplasm",{"$nulls":3},7,7,7,"16.1","16.1","16.1","69.223",0,"10.514",162740000,17,"0.101094","0.914596","0.137675","0.300235","sp|O76031|CLPX_HUMAN;tr|H0YM48|H0YM48_HUMAN;tr|H0YK07|H0YK07_HUMAN","sp|O76031|CLPX_HUMAN",386,"O76031","CLPX_HUMAN","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial",null,"CLPX"]
["16.1907","16.0959","16.9612","15.051",{"$nulls":3},"cilium assembly;immune system development;response to UV;smoothened signaling pathway;transcription from RNA polymerase III promoter","metal ion binding;RNA binding;U2 snRNA binding","cytosol;intracellular ribonucleoprotein complex;nucleoplasm","Systemic lupus erythematosus",null,null,2,2,2,"5.8","5.8","5.8","60.67",0,"4.424",19472000,3,"0.0462047","0.955641","0.137185","0.143464","sp|P10155|RO60_HUMAN;tr|D6RDN1|D6RDN1_HUMAN;tr|D6RE09|D6RE09_HUMAN","sp|P10155|RO60_HUMAN;tr|D6RDN1|D6RDN1_HUMAN;tr|D6RE09|D6RE09_HUMAN",604,"P10155","RO60_HUMAN","60 kDa SS-A/Ro ribonucleoprotein","0 kDa ribonucleoprotein Ro;0 kDa Ro protein;oRNP","TROVE2"]
["23.2847","23.1531","23.4611","22.706",{"$nulls":3},"cell surface receptor signaling pathway;decidualization;embryo implantation;extracellular matrix disassembly;extracellular matrix organization;leukocyte migration;odontogenesis of dentin-containing tooth;protein localization to plasma membrane;pyruvate metabolic process;response to cAMP;response to mercury ion;response to peptide hormone","cadherin binding;mannose binding;monocarboxylic acid transmembrane transporter activity","acrosomal membrane;extracellular exosome;focal adhesion;Golgi membrane;integral component of plasma membrane;intracellular membrane-bounded organelle;melanosome;membrane;membrane raft;mitochondrion;plasma membrane;sarcolemma",{"$nulls":3},8,8,8,"30.1","30.1","30.1","42.2",0,"71.125",1275400000,42,"0.120483","0.902692","0.135352","0.353137","sp|P35613|BASI_HUMAN;tr|A0A087WUV8|A0A087WUV8_HUMAN;tr|A0A087X2B5|A0A087X2B5_HUMAN;tr|I3L192|I3L192_HUMAN;tr|R4GMX5|R4GMX5_HUMAN;tr|R4GN83|R4GN83_HUMAN","sp|P35613|BASI_HUMAN;tr|A0A087WUV8|A0A087WUV8_HUMAN;tr|A0A087X2B5|A0A087X2B5_HUMAN;tr|I3L192|I3L192_HUMAN",936,"P35613","BASI_HUMAN","Basigin",null,"BSG"]
["17.4186","17.5597","17.8435","16.865",{"$nulls":3},"spindle organization",null,"centrosome",{"$nulls":3},2,2,2,"7.6","7.6","7.6","49.225",0,"4.4812",38963000,3,"0.0912581","0.920992","0.134934","0.27297","tr|A0A087WX12|A0A087WX12_HUMAN;tr|A0A087X032|A0A087X032_HUMAN;tr|A0A087WTH3|A0A087WTH3_HUMAN;tr|A0A087X251|A0A087X251_HUMAN;tr|A0A087X0T6|A0A087X0T6_HUMAN;sp|Q2M2Z5|KIZ_HUMAN","tr|A0A087WX12|A0A087WX12_HUMAN;tr|A0A087X032|A0A087X032_HUMAN;tr|A0A087WTH3|A0A087WTH3_HUMAN;tr|A0A087X251|A0A087X251_HUMAN;tr|A0A087X0T6|A0A087X0T6_HUMAN;sp|Q2M2Z5|KIZ_HUMAN",1769,"A0A087WX12","A0A087WX12_HUMAN",null,null,"KIZ"]
["16.2174","15.9266","16.0724","15.8028",{"$nulls":3},"microtubule-based movement","ATP binding;microtubule binding;microtubule motor activity",{"$nulls":4},4,4,3,"4.1","4.1","3.2","165.98",0,"30.508",58592000,15,"0.245871","0.781721","0.13441","0.677966","tr|F8W8V9|F8W8V9_HUMAN;sp|Q12756|KIF1A_HUMAN;tr|H7C0K6|H7C0K6_HUMAN;tr|A0A087WWA3|A0A087WWA3_HUMAN;tr|Q4R9M9|Q4R9M9_HUMAN;sp|O60333|KIF1B_HUMAN","tr|F8W8V9|F8W8V9_HUMAN;sp|Q12756|KIF1A_HUMAN;tr|H7C0K6|H7C0K6_HUMAN",1489,"F8W8V9","F8W8V9_HUMAN",null,null,"KIF1A"]
["20.9894","20.7966","20.9776","20.5401",{"$nulls":3},"ATP transport;cellular response to calcium ion;cellular response to oxidative stress;mitochondrial transport;regulation of cell death","ADP transmembrane transporter activity;ATP transmembrane transporter activity;calcium ion binding","integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},9,9,9,"29.1","29.1","29.1","53.354",0,"28.112",449420000,37,"0.199827","0.821321","0.134141","0.561102","sp|Q6NUK1|SCMC1_HUMAN;tr|J3KN42|J3KN42_HUMAN;tr|H3BMI3|H3BMI3_HUMAN","sp|Q6NUK1|SCMC1_HUMAN",1875,"Q6NUK1","SCMC1_HUMAN","Calcium-binding mitochondrial carrier protein SCaMC-1",null,"SLC25A24"]
["22.8769","22.4237","22.9348","22.0996",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of NF-kappaB transcription factor activity;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;proteolysis involved in cellular protein catabolic process;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of inflammatory response;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activity;NF-kappaB binding;purine ribonucleoside triphosphate binding;RNA binding;threonine-type endopeptidase activity","cytosol;extracellular exosome;myofibril;nuclear matrix;nucleoplasm;nucleus;P-body;polysome;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex;sarcomere","Proteasome",null,null,8,8,8,"38.6","38.6","38.6","27.399",0,"21.433",1031100000,18,"0.0938409","0.920315","0.133112","0.28016","sp|P60900|PSA6_HUMAN;tr|G3V5Z7|G3V5Z7_HUMAN;tr|G3V3I1|G3V3I1_HUMAN;tr|G3V295|G3V295_HUMAN;tr|G3V3U4|G3V3U4_HUMAN;tr|G3V4S5|G3V4S5_HUMAN;tr|G3V2S7|G3V2S7_HUMAN;tr|H0YJC4|H0YJC4_HUMAN","sp|P60900|PSA6_HUMAN;tr|G3V5Z7|G3V5Z7_HUMAN;tr|G3V3I1|G3V3I1_HUMAN;tr|G3V295|G3V295_HUMAN;tr|G3V3U4|G3V3U4_HUMAN",1244,"P60900","PSA6_HUMAN","Proteasome subunit alpha type-6",null,"PSMA6"]
["22.0717","21.7997","22.3571","21.2487",{"$nulls":9},5,5,5,"26.8","26.8","26.8","17.634",0,"78.1",302090000,21,"0.076953","0.931498","0.132801","0.232729","tr|E9PM92|E9PM92_HUMAN;sp|O00193|SMAP_HUMAN;tr|E9PQA1|E9PQA1_HUMAN;tr|E9PRZ9|E9PRZ9_HUMAN","tr|E9PM92|E9PM92_HUMAN;sp|O00193|SMAP_HUMAN;tr|E9PQA1|E9PQA1_HUMAN",125,"E9PM92","E9PM92_HUMAN",null,null,"C11orf58"]
["23.6402","23.2931","23.5234","23.1447",{"$nulls":3},"carbohydrate metabolic process;glucose transmembrane transport;glucose transport;L-ascorbic acid metabolic process;neutrophil degranulation","dehydroascorbic acid transmembrane transporter activity;D-glucose transmembrane transporter activity;glucose binding;glucose transmembrane transporter activity","extracellular exosome;ficolin-1-rich granule membrane;integral component of membrane;integral component of plasma membrane;plasma membrane;secretory granule membrane;specific granule membrane;tertiary granule membrane",{"$nulls":3},6,6,6,"12.1","12.1","12.1","53.924",0,"22.334",1511900000,37,"0.182344","0.835052","0.132571","0.516168","sp|P11169|GTR3_HUMAN;sp|Q8TDB8|GTR14_HUMAN","sp|P11169|GTR3_HUMAN;sp|Q8TDB8|GTR14_HUMAN",619,"P11169","GTR3_HUMAN","Solute carrier family 2, facilitated glucose transporter member 3",null,"SLC2A3"]
["18.7788","18.5827","19.8113","17.2876",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;intracellular protein transport;receptor-mediated endocytosis;regulation of defense response to virus by virus;response to virus;retrograde transport, endosome to Golgi","protein transporter activity","AP-1 adaptor complex;clathrin-coated endocytic vesicle membrane;clathrin-coated pit;cytoplasmic vesicle membrane;cytosol;extracellular exosome;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle;lysosomal membrane;membrane;terminal bouton;trans-Golgi network membrane","Human immunodeficiency virus 1 infection;Lysosome",null,null,1,1,1,"10.1","10.1","10.1","18.733",0,"20.621",46368000,9,"0.0329936","0.962956","0.131291","0.103737","sp|P61966|AP1S1_HUMAN;tr|H7C1E4|H7C1E4_HUMAN","sp|P61966|AP1S1_HUMAN;tr|H7C1E4|H7C1E4_HUMAN",1284,"P61966","AP1S1_HUMAN","AP-1 complex subunit sigma-1A",null,"AP1S1"]
["20.5537","20.7731","20.7409","20.3242",{"$nulls":3},"cellular response to estrogen stimulus;positive regulation of gene expression, epigenetic","RNA polymerase II transcription coactivator activity","nuclear chromatin",{"$nulls":3},1,1,1,"8.8","8.8","8.8","11.967","0.0010905","2.5379",70946000,2,"0.197791","0.823285","0.130887","0.555887","tr|K7EIN1|K7EIN1_HUMAN;tr|K7ESN4|K7ESN4_HUMAN;tr|K7EIJ0|K7EIJ0_HUMAN;tr|K7EIK1|K7EIK1_HUMAN;tr|K7ENL2|K7ENL2_HUMAN;tr|A6NG10|A6NG10_HUMAN;tr|K7EMC9|K7EMC9_HUMAN;sp|Q969T9|WBP2_HUMAN","tr|K7EIN1|K7EIN1_HUMAN;tr|K7ESN4|K7ESN4_HUMAN;tr|K7EIJ0|K7EIJ0_HUMAN;tr|K7EIK1|K7EIK1_HUMAN;tr|K7ENL2|K7ENL2_HUMAN;tr|A6NG10|A6NG10_HUMAN;tr|K7EMC9|K7EMC9_HUMAN;sp|Q969T9|WBP2_HUMAN",2222,"K7EIN1","K7EIN1_HUMAN",null,null,"WBP2"]
["18.525","18.483","18.4356","18.3113",{"$nulls":9},2,2,2,"44.1","44.1","44.1","9.5162",0,"3.8326",21841000,6,"0.733102","0.348739","0.130562","1.98991","tr|J3KSH8|J3KSH8_HUMAN;sp|Q9UK76|HN1_HUMAN;tr|J3KT51|J3KT51_HUMAN","tr|J3KSH8|J3KSH8_HUMAN;sp|Q9UK76|HN1_HUMAN;tr|J3KT51|J3KT51_HUMAN",2865,"J3KSH8","J3KSH8_HUMAN",null,null,"JPT1"]
["19.0874",1,"18.8299",1,{"$nulls":9},1,1,1,"33.3","33.3","33.3","5.4078","0.0010846","2.4934",4580700,1,"0.00312445","0.991806","0.128743","0.010138","tr|G3V549|G3V549_HUMAN;sp|Q9H9C1|SPE39_HUMAN;tr|G3V4K3|G3V4K3_HUMAN","tr|G3V549|G3V549_HUMAN;sp|Q9H9C1|SPE39_HUMAN;tr|G3V4K3|G3V4K3_HUMAN",2622,"G3V549","G3V549_HUMAN",null,null,"VIPAS39"]
["20.7091","20.8336","21.2176","20.0705",{"$nulls":3},"liver development;mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;negative regulation of DNA damage checkpoint;positive regulation of cell growth involved in cardiac muscle cell development;positive regulation of DNA biosynthetic process;positive regulation of DNA-templated transcription, elongation;positive regulation of translation;positive regulation of vascular smooth muscle cell proliferation;RNA export from nucleus;RNA secondary structure unwinding;RNA splicing;spliceosomal complex assembly;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus","ATP binding;ATPase activity;ATP-dependent protein binding;ATP-dependent RNA helicase activity;identical protein binding;protein complex binding;RNA binding;RNA-dependent ATPase activity;U4 snRNA binding;U6 snRNA binding","cytoplasm;nuclear matrix;nuclear speck;nucleolus;nucleoplasm;nucleus;spliceosomal complex;transcription export complex","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,6,6,6,"17.5","17.5","17.5","48.991",0,"15.724",270830000,10,"0.0727255","0.930969","0.127316","0.220692","sp|Q13838|DX39B_HUMAN;tr|Q5STU3|Q5STU3_HUMAN;tr|F6S4E6|F6S4E6_HUMAN;tr|A0A0A0MT12|A0A0A0MT12_HUMAN;tr|F6TRA5|F6TRA5_HUMAN;tr|F6WLT2|F6WLT2_HUMAN;sp|O00148|DX39A_HUMAN;tr|A0A0G2JHN7|A0A0G2JHN7_HUMAN;tr|F6U6E2|F6U6E2_HUMAN;tr|F6S2B7|F6S2B7_HUMAN;tr|F6R6M7|F6R6M7_HUMAN;tr|A0A0G2JJZ9|A0A0G2JJZ9_HUMAN;tr|H0Y400|H0Y400_HUMAN;tr|K7EQN7|K7EQN7_HUMAN;tr|K7ENP6|K7ENP6_HUMAN;tr|K7EL56|K7EL56_HUMAN;tr|K7EIL8|K7EIL8_HUMAN;tr|K7EN69|K7EN69_HUMAN;tr|F6SXL5|F6SXL5_HUMAN;tr|F6QYI9|F6QYI9_HUMAN;tr|A0A0G2JJL7|A0A0G2JJL7_HUMAN;tr|K7EPJ3|K7EPJ3_HUMAN;tr|F6UJC5|F6UJC5_HUMAN","sp|Q13838|DX39B_HUMAN;tr|Q5STU3|Q5STU3_HUMAN;tr|F6S4E6|F6S4E6_HUMAN;tr|A0A0A0MT12|A0A0A0MT12_HUMAN;tr|F6TRA5|F6TRA5_HUMAN;tr|F6WLT2|F6WLT2_HUMAN;sp|O00148|DX39A_HUMAN;tr|A0A0G2JHN7|A0A0G2JHN7_HUMAN;tr|F6U6E2|F6U6E2_HUMAN;tr|F6S2B7|F6S2B7_HUMAN;tr|F6R6M7|F6R6M7_HUMAN;tr|A0A0G2JJZ9|A0A0G2JJZ9_HUMAN",1588,"Q13838","DX39B_HUMAN","Spliceosome RNA helicase DDX39B",null,"DDX39B"]
["18.0328","16.3835","17.411","16.7533",{"$nulls":3},"7-methylguanosine mRNA capping;cap1 mRNA methylation;mRNA methylation","mRNA (nucleoside-2'-O-)-methyltransferase activity;nucleic acid binding","cytosol;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"6.3","6.3","6.3","95.32","0.00038895","3.1153",44866000,4,"0.0456949","0.955745","0.126025","0.141948","sp|Q8N1G2|CMTR1_HUMAN;tr|Q5T7F5|Q5T7F5_HUMAN","sp|Q8N1G2|CMTR1_HUMAN;tr|Q5T7F5|Q5T7F5_HUMAN",2037,"Q8N1G2","CMTR1_HUMAN","Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1",null,"CMTR1"]
["16.1631","16.044","16.5186","15.4389",{"$nulls":3},"G-protein coupled receptor signaling pathway;inositol phosphate metabolic process;intracellular signal transduction;lipid catabolic process;regulation of systemic arterial blood pressure;Wnt signaling pathway, calcium modulating pathway","cadherin binding;calcium ion binding;calmodulin binding;phosphatidylinositol phospholipase C activity;phospholipase C activity;signal transducer activity","cytosol;membrane;nucleoplasm;protein complex","Adrenergic signaling in cardiomyocytes;African trypanosomiasis;AGE-RAGE signaling pathway in diabetic complications;Aldosterone synthesis and secretion;Alzheimer disease;Amoebiasis;Apelin signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cortisol synthesis and secretion;Cushing syndrome;Dopaminergic synapse;Endocrine and other factor-regulated calcium reabsorption;Estrogen signaling pathway;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Human cytomegalovirus infection;Huntington disease;Inflammatory mediator regulation of TRP channels;Inositol phosphate metabolism;Insulin secretion;Long-term depression;Long-term potentiation;Melanogenesis;Metabolic pathways;NOD-like receptor signaling pathway;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;Platelet activation;Rap1 signaling pathway;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Sphingolipid signaling pathway;Thyroid hormone signaling pathway;Thyroid hormone synthesis;Vascular smooth muscle contraction;Wnt signaling pathway",null,null,4,4,4,"7.6","7.6","7.6","138.8",0,"32.359",35507000,8,"0.0759205","0.931131","0.124811","0.229795","sp|Q01970|PLCB3_HUMAN","sp|Q01970|PLCB3_HUMAN",1424,"Q01970","PLCB3_HUMAN","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3",null,"PLCB3"]
["17.711","18.2655","17.5993","18.1341",{"$nulls":3},"ATP-dependent chromatin remodeling;chromatin remodeling;covalent chromatin modification;negative regulation of transcription, DNA-templated;nervous system development;nucleosome disassembly;positive regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","DNA binding;transcription coactivator activity","nBAF complex;npBAF complex;nuclear chromatin;nucleoplasm;protein complex;SWI/SNF complex","Hepatocellular carcinoma;Thermogenesis",null,null,5,5,5,"6.8","6.8","6.8","132.88",0,"15.147",124250000,6,"0.106727","0.912116","0.121609","0.315716","sp|Q8TAQ2|SMRC2_HUMAN;tr|F8VXC8|F8VXC8_HUMAN;tr|F8VZW6|F8VZW6_HUMAN","sp|Q8TAQ2|SMRC2_HUMAN;tr|F8VXC8|F8VXC8_HUMAN",2107,"Q8TAQ2","SMRC2_HUMAN","SWI/SNF complex subunit SMARCC2",null,"SMARCC2"]
["17.1159","17.233","17.1924","16.9147",{"$nulls":3},"branchiomotor neuron axon guidance;dichotomous subdivision of terminal units involved in salivary gland branching;multicellular organism development;neuron projection extension;regulation of axon extension involved in axon guidance;regulation of smooth muscle cell migration","receptor activity;semaphorin receptor activity","extracellular exosome;integral component of membrane;plasma membrane;semaphorin receptor complex","Axon guidance",null,null,2,2,2,"0.7","0.7","0.7","211.06","0.0053763","1.908",134490000,9,"0.295487","0.733539","0.120927","0.802603","sp|Q9UIW2|PLXA1_HUMAN","sp|Q9UIW2|PLXA1_HUMAN",2852,"Q9UIW2","PLXA1_HUMAN","Plexin-A1",null,"PLXNA1"]
["16.1066","16.1858","16.6852","15.3656",{"$nulls":3},"apoptotic process;cell differentiation;epidermis development;hair follicle development;odontogenesis of dentin-containing tooth;pigmentation;positive regulation of gene expression;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of JNK cascade;positive regulation of NF-kappaB import into nucleus;salivary gland cavitation;tumor necrosis factor-mediated signaling pathway","receptor activity;transmembrane signaling receptor activity","apical part of cell;integral component of membrane;plasma membrane","Cytokine-cytokine receptor interaction;NF-kappa B signaling pathway",null,null,1,1,1,"3.3","3.3","3.3","48.582","0.00039841","3.3419",11173000,3,"0.0595402","0.944965","0.120753","0.182686","sp|Q9UNE0|EDAR_HUMAN","sp|Q9UNE0|EDAR_HUMAN",2907,"Q9UNE0","EDAR_HUMAN","Tumor necrosis factor receptor superfamily member EDAR",null,"EDAR"]
["20.6024","20.0867","20.4185","20.0293",{"$nulls":4},"aldehyde dehydrogenase (NAD) activity","extracellular exosome;membrane",{"$nulls":3},8,8,8,"13.5","13.5","13.5","85.126",0,"23.91",341440000,32,"0.127986","0.897375","0.120612","0.373337","sp|Q8IZ83|A16A1_HUMAN;tr|F5H4B6|F5H4B6_HUMAN;tr|M0QY06|M0QY06_HUMAN","sp|Q8IZ83|A16A1_HUMAN;tr|F5H4B6|F5H4B6_HUMAN",2029,"Q8IZ83","A16A1_HUMAN","Aldehyde dehydrogenase family 16 member A1",null,"ALDH16A1"]
["18.7258","18.4273","18.8804","18.0322",{"$nulls":3},"branched-chain amino acid catabolic process;cellular nitrogen compound metabolic process","3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;alpha-ketoacid dehydrogenase activity;carboxy-lyase activity;metal ion binding","mitochondrial alpha-ketoglutarate dehydrogenase complex;mitochondrial matrix;mitochondrion","Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,5,5,5,"16.2","16.2","16.2","50.47",0,"25.423",94829000,15,"0.0892873","0.922269","0.120246","0.267469","sp|P12694|ODBA_HUMAN;tr|F5H5P2|F5H5P2_HUMAN;tr|F5GXU9|F5GXU9_HUMAN;tr|M0R0C8|M0R0C8_HUMAN;tr|H0YH31|H0YH31_HUMAN","sp|P12694|ODBA_HUMAN;tr|F5H5P2|F5H5P2_HUMAN;tr|F5GXU9|F5GXU9_HUMAN",648,"P12694","ODBA_HUMAN","2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial",null,"BCKDHA"]
["18.7913","18.224","18.6427","18.1335",{"$nulls":3},"cellular protein localization;positive regulation of transcription from RNA polymerase II promoter",null,"integral component of mitochondrial outer membrane;nucleus",{"$nulls":3},4,4,4,"16.6","16.6","16.6","42.5",0,"11.058",77042000,12,"0.106019","0.913505","0.119605","0.313773","sp|Q9UH62|ARMX3_HUMAN;tr|H3BM63|H3BM63_HUMAN;tr|H3BV87|H3BV87_HUMAN","sp|Q9UH62|ARMX3_HUMAN",2825,"Q9UH62","ARMX3_HUMAN","Armadillo repeat-containing X-linked protein 3",null,"ARMCX3"]
["18.0026","18.0651","18.3888","17.4403",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;determination of left/right symmetry;heart development;intracellular protein transport;regulation of defense response to virus by virus;vesicle-mediated transport","protein kinase binding;protein transporter activity;transporter activity","clathrin adaptor complex;clathrin-coated endocytic vesicle membrane;cytoplasmic vesicle membrane;cytosol;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle;lysosomal membrane;trans-Golgi network membrane","Human immunodeficiency virus 1 infection;Lysosome",null,null,8,4,4,"12.9","7.9","7.9","104.64",0,"265.97",109760000,18,"0.0834296","0.927223","0.119315","0.251038","sp|Q10567|AP1B1_HUMAN;tr|C9J1E7|C9J1E7_HUMAN;tr|A0A087WYD1|A0A087WYD1_HUMAN;tr|A0A087WU93|A0A087WU93_HUMAN;tr|A0A087WZQ6|A0A087WZQ6_HUMAN;tr|K7EJ01|K7EJ01_HUMAN;tr|H7C034|H7C034_HUMAN","sp|Q10567|AP1B1_HUMAN;tr|C9J1E7|C9J1E7_HUMAN",1487,"Q10567","AP1B1_HUMAN","AP-1 complex subunit beta-1",null,"AP1B1"]
["14.7453","14.4633","15.1188","13.8536",{"$nulls":3},"negative regulation of translation","identical protein binding;mRNA binding;protein heterodimerization activity;protein homodimerization activity;RNA binding","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;membrane;nucleus;polysome","RNA transport",null,null,2,1,1,"4.5","3.3","3.3","74.222",0,"3.7749",10441000,4,"0.0593707","0.944243","0.118083","0.182192","sp|P51116|FXR2_HUMAN;tr|E7EU85|E7EU85_HUMAN;tr|E9PFF5|E9PFF5_HUMAN;tr|R9WNI0|R9WNI0_HUMAN;sp|Q06787|FMR1_HUMAN","sp|P51116|FXR2_HUMAN;tr|E7EU85|E7EU85_HUMAN;tr|E9PFF5|E9PFF5_HUMAN;tr|R9WNI0|R9WNI0_HUMAN;sp|Q06787|FMR1_HUMAN",1129,"P51116","FXR2_HUMAN","Fragile X mental retardation syndrome-related protein 2",null,"FXR2"]
["15.8252","15.4457","15.6785","15.3565",{"$nulls":3},"actin cytoskeleton reorganization;axis elongation;canonical Wnt signaling pathway;cell adhesion;cell migration;cellular response to retinoic acid;cochlea morphogenesis;convergent extension;coronary vasculature development;establishment of epithelial cell apical/basal polarity;establishment of planar polarity;lung-associated mesenchyme development;planar cell polarity pathway involved in neural tube closure;positive regulation of neuron projection development;signal transduction;ventricular septum development;wound healing","ATP binding;coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway;protein kinase activity","cell-cell junction;focal adhesion;integral component of plasma membrane",{"$nulls":3},3,3,3,3,3,3,"118.39",0,"3.5154",21120000,2,"0.166101","0.857352","0.117954","0.474045","sp|Q13308|PTK7_HUMAN;tr|H7C5L0|H7C5L0_HUMAN;tr|H0Y8F1|H0Y8F1_HUMAN;tr|Q86X91|Q86X91_HUMAN","sp|Q13308|PTK7_HUMAN;tr|H7C5L0|H7C5L0_HUMAN",1541,"Q13308","PTK7_HUMAN","Inactive tyrosine-protein kinase 7",null,"PTK7"]
["18.1079","18.1755","19.0867","16.9675",{"$nulls":3},"synaptic vesicle docking",null,"integral component of membrane;presynapse",{"$nulls":3},2,2,2,"11.3","11.3","11.3","23.243","0.0011236","2.7969",27220000,2,"0.0344372","0.961342","0.114627","0.108123","tr|A0A0C4DGE4|A0A0C4DGE4_HUMAN;tr|F8W9Y0|F8W9Y0_HUMAN;tr|A0A0J9YW33|A0A0J9YW33_HUMAN;sp|Q13277|STX3_HUMAN","tr|A0A0C4DGE4|A0A0C4DGE4_HUMAN;tr|F8W9Y0|F8W9Y0_HUMAN;tr|A0A0J9YW33|A0A0J9YW33_HUMAN;sp|Q13277|STX3_HUMAN",1539,"A0A0C4DGE4","A0A0C4DGE4_HUMAN",null,null,"STX3"]
["17.9273","18.2776","18.6637","17.3195",{"$nulls":3},"apoptotic process;cell division;DNA recombination;double-strand break repair;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of mitotic metaphase/anaphase transition;positive regulation of sister chromatid cohesion;protein localization to chromatin;reciprocal meiotic recombination;regulation of transcription from RNA polymerase II promoter;sister chromatid cohesion","chromatin binding;protein complex binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","chromatin;chromosome;chromosome, centromeric region;cohesin complex;cytosol;membrane;nuclear cohesin complex;nuclear matrix;nucleoplasm","Cell cycle",null,null,4,4,4,"11.9","11.9","11.9","71.689",0,"33.629",47798000,11,"0.0516663","0.948884","0.110861","0.159628","sp|O60216|RAD21_HUMAN","sp|O60216|RAD21_HUMAN",279,"O60216","RAD21_HUMAN","Double-strand-break repair protein rad21 homolog","HR21","RAD21"]
["20.7466","20.7848","20.6652","20.6477",{"$nulls":4},"DNA binding","mitochondrion;nucleus",{"$nulls":3},3,3,3,"13.7","13.7","13.7","25.567",0,"6.009",179120000,11,"1.45551","0.319681","0.109213","5.20118","tr|H7BYN3|H7BYN3_HUMAN;sp|Q00059|TFAM_HUMAN","tr|H7BYN3|H7BYN3_HUMAN;sp|Q00059|TFAM_HUMAN",1399,"H7BYN3","H7BYN3_HUMAN",null,null,"TFAM"]
["20.9704","20.8249","21.0233","20.5536",{"$nulls":9},1,1,1,17,17,17,"5.3162","0.0078611","1.7343",35631000,2,"0.15462","0.871911","0.109173","0.44401","tr|C9JDY4|C9JDY4_HUMAN;tr|C9J5J2|C9J5J2_HUMAN;tr|C9JE02|C9JE02_HUMAN;tr|H7C5G1|H7C5G1_HUMAN;sp|Q2TAA2|IAH1_HUMAN","tr|C9JDY4|C9JDY4_HUMAN;tr|C9J5J2|C9J5J2_HUMAN;tr|C9JE02|C9JE02_HUMAN;tr|H7C5G1|H7C5G1_HUMAN;sp|Q2TAA2|IAH1_HUMAN",1774,"C9JDY4","C9JDY4_HUMAN",null,null,"IAH1"]
["21.2913","21.088","21.2303","20.9308",{"$nulls":3},"anaerobic respiration;mitochondrial electron transport, succinate to ubiquinone;nervous system development;oxidation-reduction process;respiratory electron transport chain;succinate metabolic process;tricarboxylic acid cycle","electron transfer activity;flavin adenine dinucleotide binding;succinate dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);mitochondrion;myelin sheath;nucleolus","Alzheimer disease;Carbon metabolism;Citrate cycle (TCA cycle);Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,9,9,9,"21.7","21.7","21.7","72.691",0,"76.049",660230000,48,"0.216224","0.803597","0.109106","0.602924","sp|P31040|SDHA_HUMAN;tr|D6RFM5|D6RFM5_HUMAN;tr|A0A087X1I3|A0A087X1I3_HUMAN;tr|H0Y8X1|H0Y8X1_HUMAN","sp|P31040|SDHA_HUMAN;tr|D6RFM5|D6RFM5_HUMAN;tr|A0A087X1I3|A0A087X1I3_HUMAN",881,"P31040","SDHA_HUMAN","Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",null,"SDHA"]
["21.9417","21.9554","22.3185","21.3614",{"$nulls":3},"actin cytoskeleton organization;actin cytoskeleton reorganization;alpha-beta T cell lineage commitment;androgen receptor signaling pathway;angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure;apical junction assembly;apolipoprotein A-I-mediated signaling pathway;beta selection;cell junction assembly;cell migration;cell-matrix adhesion;cellular response to chemokine;cellular response to lipopolysaccharide;cerebral cortex cell migration;cleavage furrow formation;endothelial cell migration;endothelial tube lumen extension;ephrin receptor signaling pathway;establishment of epithelial cell apical/basal polarity;forebrain radial glial cell differentiation;G-protein coupled receptor signaling pathway;GTP metabolic process;mitotic cleavage furrow formation;mitotic spindle assembly;negative chemotaxis;negative regulation of axonogenesis;negative regulation of cell migration involved in sprouting angiogenesis;negative regulation of cell size;negative regulation of cell-substrate adhesion;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of intracellular steroid hormone receptor signaling pathway;negative regulation of neuron apoptotic process;negative regulation of oxidative phosphorylation;negative regulation of reactive oxygen species biosynthetic process;neuron projection morphogenesis;neutrophil degranulation;odontogenesis;ossification involved in bone maturation;phosphatidylinositol-mediated signaling;platelet activation;positive regulation of actin filament polymerization;positive regulation of alpha-beta T cell differentiation;positive regulation of axonogenesis;positive regulation of cell growth;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cytokinesis;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of lipase activity;positive regulation of neuron apoptotic process;positive regulation of neuron differentiation;positive regulation of NF-kappaB import into nucleus;positive regulation of podosome assembly;positive regulation of protein serine/threonine kinase activity;positive regulation of stress fiber assembly;positive regulation of T cell migration;positive regulation of translation;positive regulation of vascular smooth muscle contraction;protein deubiquitination;regulation of actin cytoskeleton organization;regulation of calcium ion transport;regulation of cell migration;regulation of cell motility;regulation of dendrite development;regulation of focal adhesion assembly;regulation of microtubule cytoskeleton organization;regulation of modification of synaptic structure;regulation of neural precursor cell proliferation;regulation of osteoblast proliferation;regulation of small GTPase mediated signal transduction;regulation of systemic arterial blood pressure by endothelin;regulation of transcription from RNA polymerase II promoter;response to amino acid;response to drug;response to ethanol;response to glucocorticoid;response to glucose;response to hypoxia;response to mechanical stimulus;Rho protein signal transduction;Roundabout signaling pathway;skeletal muscle satellite cell migration;skeletal muscle tissue development;stress fiber assembly;stress-activated protein kinase signaling cascade;substantia nigra development;trabecula morphogenesis;transforming growth factor beta receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway;wound healing, spreading of cells","GDP binding;GTP binding;GTPase activity;myosin binding;protein domain specific binding;Rho GDP-dissociation inhibitor binding","apical junction complex;axon;cell cortex;cell junction;cell periphery;cleavage furrow;cytoskeleton;cytosol;dendritic spine;endoplasmic reticulum membrane;endosome;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane;ficolin-1-rich granule membrane;focal adhesion;lamellipodium;midbody;mitochondrion;nucleus;plasma membrane;ruffle membrane;secretory granule membrane;vesicle","Adherens junction;Axon guidance;Bacterial invasion of epithelial cells;cAMP signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Colorectal cancer;C-type lectin receptor signaling pathway;Endocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;Human cytomegalovirus infection;Leukocyte transendothelial migration;MicroRNAs in cancer;mTOR signaling pathway;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Pathogenic Escherichia coli infection;Pathways in cancer;Pertussis;Phospholipase D signaling pathway;Platelet activation;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Sphingolipid signaling pathway;T cell receptor signaling pathway;TGF-beta signaling pathway;Tight junction;Tuberculosis;Vascular smooth muscle contraction;Viral carcinogenesis;Wnt signaling pathway;Yersinia infection",null,null,5,5,3,"39.4","39.4","26.4","21.768",0,"66.499",294070000,19,"0.0749309","0.93082","0.108631","0.22698","sp|P61586|RHOA_HUMAN;tr|C9JNR4|C9JNR4_HUMAN;tr|C9JX21|C9JX21_HUMAN;tr|C9JRM1|C9JRM1_HUMAN","sp|P61586|RHOA_HUMAN",1274,"P61586","RHOA_HUMAN","Transforming protein RhoA",null,"RHOA"]
["22.8612","22.977","23.3369","22.2842",{"$nulls":3},"cell proliferation;IRE1-mediated unfolded protein response;negative regulation of transcription from RNA polymerase II promoter;signal transduction;transcription, DNA-templated","DNA binding;growth factor activity;heparin binding;nucleotide binding;RNA binding;RNA polymerase II transcription corepressor activity;transcription corepressor binding","cytoplasm;extracellular matrix;extracellular region;extracellular space;nucleoplasm;transcriptional repressor complex",{"$nulls":3},10,10,9,"48.8","48.8","45.4","26.788",0,"77.085",1139600000,42,"0.0672598","0.935842","0.108562","0.205025","sp|P51858|HDGF_HUMAN","sp|P51858|HDGF_HUMAN",1148,"P51858","HDGF_HUMAN","Hepatoma-derived growth factor","DGF","HDGF"]
["22.7294","22.66","22.8338","22.3398",{"$nulls":3},"regulation of cell proliferation","protein heterodimerization activity;protein homodimerization activity;RNA binding","cytoplasm;perinuclear region of cytoplasm",{"$nulls":3},6,6,6,"41.7","41.7","41.7","22.237",0,"29.446",620450000,30,"0.150243","0.875899","0.107891","0.432496","sp|O43399|TPD54_HUMAN;tr|A0A087WYR3|A0A087WYR3_HUMAN;tr|A0A087WZ51|A0A087WZ51_HUMAN","sp|O43399|TPD54_HUMAN;tr|A0A087WYR3|A0A087WYR3_HUMAN;tr|A0A087WZ51|A0A087WZ51_HUMAN",246,"O43399","TPD54_HUMAN","Tumor protein D54","D54","TPD52L2"]
["20.8251","20.0254","21.1012","19.5361",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;oxidation-reduction process;oxidative phosphorylation;protein processing;response to activity;response to alkaloid","metalloendopeptidase activity;protein complex binding;ubiquinol-cytochrome-c reductase activity;ubiquitin protein ligase binding;zinc ion binding","cytosol;mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrial respiratory chain complex III;mitochondrion;myelin sheath","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,7,7,6,"21.5","21.5",20,"52.645",0,"82.587",314650000,42,"0.0387947","0.957263","0.106596","0.121295","sp|P31930|QCR1_HUMAN","sp|P31930|QCR1_HUMAN",891,"P31930","QCR1_HUMAN","Cytochrome b-c1 complex subunit 1, mitochondrial",null,"UQCRC1"]
["21.8729","21.866","21.9253","21.6009",{"$nulls":3},"nucleosome assembly","cadherin binding;DNA binding;RNA binding","nucleolus;nucleosome;nucleus",{"$nulls":3},2,2,2,"12.7","12.7","12.7","22.487",0,"40.375",284890000,17,"0.236927","0.788295","0.106344","0.655391","sp|Q92522|H1X_HUMAN","sp|Q92522|H1X_HUMAN",2167,"Q92522","H1X_HUMAN","Histone H1x",null,"H1FX"]
["20.67","21.2072","20.3779","21.2899",{"$nulls":3},"cellular response to thyroid hormone stimulus;collagen catabolic process;decidualization;epithelial cell differentiation;neutrophil degranulation;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of apoptotic process;regulation of catalytic activity;toll-like receptor signaling pathway;viral entry into host cell","collagen binding;cysteine-type endopeptidase activity;cysteine-type peptidase activity;peptidase activity;proteoglycan binding;serine-type endopeptidase activity","endolysosome lumen;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;intracellular;intracellular membrane-bounded organelle;lysosome;melanosome;mitochondrion;nucleolus;perinuclear region of cytoplasm","Antigen processing and presentation;Apoptosis;Autophagy - animal;Lysosome;NOD-like receptor signaling pathway;Renin secretion",null,null,3,3,3,"12.7","12.7","12.7","37.821",0,"54.374",271560000,23,"0.0647753","0.937143","0.104712","0.197863","sp|P07858|CATB_HUMAN","sp|P07858|CATB_HUMAN",549,"P07858","CATB_HUMAN","Cathepsin B",null,"CTSB"]
["22.0479","21.7915","22.1671","21.4644",{"$nulls":3},"fatty acid beta-oxidation","isomerase activity;receptor binding","extracellular exosome;membrane;mitochondrion;peroxisome","Peroxisome",null,null,6,6,5,"30.8","30.8","22.6","35.816",0,"20.467",547210000,33,"0.0930553","0.920129","0.103972","0.277975","sp|Q13011|ECH1_HUMAN;tr|M0R248|M0R248_HUMAN;tr|M0QZW4|M0QZW4_HUMAN","sp|Q13011|ECH1_HUMAN;tr|M0R248|M0R248_HUMAN",1512,"Q13011","ECH1_HUMAN","Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial",null,"ECH1"]
["21.1784","21.3625","21.6572","20.6763",{"$nulls":3},"cell proliferation;mRNA splicing, via spliceosome;neuronal stem cell population maintenance;positive regulation of neurogenesis;primary miRNA processing;regulation of transcription, DNA-templated;response to arsenic-containing substance;snRNA transcription from RNA polymerase II promoter","DNA binding;RNA binding","cytoplasm;nucleoplasm;protein complex",{"$nulls":3},11,11,11,"16.4","16.4","16.4","100.67",0,"83.137",867890000,65,"0.0682268","0.935976","0.103698","0.207806","sp|Q9BXP5|SRRT_HUMAN;tr|H7C3A1|H7C3A1_HUMAN;tr|H7C1K0|H7C1K0_HUMAN;tr|H7C0U8|H7C0U8_HUMAN;tr|A0A0A0MSP6|A0A0A0MSP6_HUMAN","sp|Q9BXP5|SRRT_HUMAN;tr|H7C3A1|H7C3A1_HUMAN",2498,"Q9BXP5","SRRT_HUMAN","Serrate RNA effector molecule homolog",null,"SRRT"]
["17.3236","17.4489","17.5448","17.0246",{"$nulls":4},"metal ion binding",{"$nulls":4},1,1,1,"9.4","9.4","9.4","20.6",0,"3.8494",12211000,6,"0.130281","0.898363","0.101519","0.379488","tr|H0YFA4|H0YFA4_HUMAN;sp|P52943|CRIP2_HUMAN","tr|H0YFA4|H0YFA4_HUMAN;sp|P52943|CRIP2_HUMAN",1171,"H0YFA4","H0YFA4_HUMAN",null,null,"CRIP2"]
["23.1469","22.7486","23.1594","22.5344",{"$nulls":3},"tricarboxylic acid cycle","citrate (Si)-synthase activity","mitochondrion",{"$nulls":3},12,12,11,"38.6","38.6","36.6","50.431",0,"28.098",1504900000,51,"0.090937","0.920989","0.10082","0.272074","tr|B4DJV2|B4DJV2_HUMAN;sp|O75390|CISY_HUMAN;tr|A0A0C4DGI3|A0A0C4DGI3_HUMAN;tr|H0YIC4|H0YIC4_HUMAN;tr|F8VTT8|F8VTT8_HUMAN;tr|F8W4S1|F8W4S1_HUMAN;tr|H0YH82|H0YH82_HUMAN;tr|F8VRP1|F8VRP1_HUMAN;tr|F8VX68|F8VX68_HUMAN;tr|F8VPF9|F8VPF9_HUMAN;tr|F8VPA1|F8VPA1_HUMAN;tr|F8W1S4|F8W1S4_HUMAN;tr|F8W642|F8W642_HUMAN;tr|F8VZK9|F8VZK9_HUMAN;tr|F8VX07|F8VX07_HUMAN;tr|F8VU34|F8VU34_HUMAN;tr|F8VR34|F8VR34_HUMAN;tr|F8VRI6|F8VRI6_HUMAN","tr|B4DJV2|B4DJV2_HUMAN;sp|O75390|CISY_HUMAN;tr|A0A0C4DGI3|A0A0C4DGI3_HUMAN",339,"B4DJV2","B4DJV2_HUMAN","Citrate synthase {ECO:0000256|RuleBase:RU000441}",null,"CS"]
["16.5805","16.6422","17.0552","15.9668",{"$nulls":9},1,1,1,"11.8","11.8","11.8","27.162","0.0020899","2.2192",12978000,4,"0.0600308","0.944422","0.100349","0.184113","tr|I3L184|I3L184_HUMAN;tr|E7EVT8|E7EVT8_HUMAN;tr|F6VX93|F6VX93_HUMAN;sp|Q5VIR6|VPS53_HUMAN","tr|I3L184|I3L184_HUMAN;tr|E7EVT8|E7EVT8_HUMAN;tr|F6VX93|F6VX93_HUMAN;sp|Q5VIR6|VPS53_HUMAN",1842,"I3L184","I3L184_HUMAN",null,null,"VPS53"]
["21.1535","21.0552","21.112","20.8964",{"$nulls":3},"apoptotic process;tRNA aminoacylation for protein translation;tyrosyl-tRNA aminoacylation","ATP binding;interleukin-8 receptor binding;RNA binding;signal transducer activity;tRNA binding;tyrosine-tRNA ligase activity","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;extracellular space;methionyl glutamyl tRNA synthetase complex;nuclear body","Aminoacyl-tRNA biosynthesis",null,null,12,12,12,"26.1","26.1","26.1","59.143",0,"35.29",788970000,40,"0.312711","0.714434","0.100199","0.845781","sp|P54577|SYYC_HUMAN;tr|A0A0C4DGZ5|A0A0C4DGZ5_HUMAN","sp|P54577|SYYC_HUMAN;tr|A0A0C4DGZ5|A0A0C4DGZ5_HUMAN",1191,"P54577","SYYC_HUMAN","Tyrosine--tRNA ligase, cytoplasmic",null,"YARS"]
["19.8643","19.1457","19.5137","19.301",{"$nulls":3},"protein folding in endoplasmic reticulum",null,"cytoplasm;endoplasmic reticulum;ER membrane protein complex;mitochondrion;nucleus",{"$nulls":3},3,3,3,"12.1","12.1","12.1","34.833",0,"3.6305",90395000,3,"0.0868262","0.92551","0.0976477","0.26058","sp|Q15006|EMC2_HUMAN;tr|H0YAS9|H0YAS9_HUMAN","sp|Q15006|EMC2_HUMAN",1658,"Q15006","EMC2_HUMAN","ER membrane protein complex subunit 2",null,"EMC2"]
["17.2935","17.9204","17.2065","17.8133",{"$nulls":3},"aspartate transport;gluconeogenesis;L-glutamate transport;malate-aspartate shuttle;response to calcium ion","acidic amino acid transmembrane transporter activity;calcium ion binding;L-aspartate transmembrane transporter activity;L-glutamate transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane;mitochondrion;myelin sheath",{"$nulls":3},4,3,3,"7.8",6,6,"74.761",0,"6.414",58018000,8,"0.0733383","0.930046","0.0970478","0.222441","sp|O75746|CMC1_HUMAN;tr|F8W9J0|F8W9J0_HUMAN;tr|H0YFB2|H0YFB2_HUMAN;tr|B4DGK6|B4DGK6_HUMAN","sp|O75746|CMC1_HUMAN",364,"O75746","CMC1_HUMAN","Calcium-binding mitochondrial carrier protein Aralar1",null,"SLC25A12"]
["23.8232","23.6605","23.6444","23.6458",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of peptide antigen via MHC class I;ATF6-mediated unfolded protein response;cardiac muscle cell differentiation;cellular calcium ion homeostasis;cellular response to lithium ion;cellular senescence;chaperone-mediated protein folding;cortical actin cytoskeleton organization;glucocorticoid receptor signaling pathway;negative regulation of cell cycle arrest;negative regulation of intracellular steroid hormone receptor signaling pathway;negative regulation of neuron differentiation;negative regulation of retinoic acid receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of translation;negative regulation of trophoblast cell migration;peptide antigen assembly with MHC class I protein complex;positive regulation of cell cycle;positive regulation of cell proliferation;positive regulation of dendritic cell chemotaxis;positive regulation of DNA replication;positive regulation of endothelial cell migration;positive regulation of gene expression;positive regulation of NIK/NF-kappaB signaling;positive regulation of phagocytosis;positive regulation of substrate adhesion-dependent cell spreading;protein export from nucleus;protein folding;protein folding in endoplasmic reticulum;protein localization to nucleus;protein maturation by protein folding;protein stabilization;receptor-mediated endocytosis;regulation of apoptotic process;regulation of meiotic nuclear division;regulation of transcription, DNA-templated;response to drug;response to estradiol;response to testosterone;sequestering of calcium ion;spermatogenesis;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane","androgen receptor binding;calcium ion binding;carbohydrate binding;chaperone binding;complement component C1q binding;DNA binding;hormone binding;integrin binding;iron ion binding;mRNA binding;peptide binding;protein binding involved in protein folding;RNA binding;ubiquitin protein ligase binding;unfolded protein binding;zinc ion binding","acrosomal vesicle;cell surface;cytoplasm;cytosol;endocytic vesicle lumen;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment membrane;external side of plasma membrane;extracellular exosome;extracellular region;extracellular space;focal adhesion;Golgi apparatus;integral component of lumenal side of endoplasmic reticulum membrane;intracellular;membrane;MHC class I peptide loading complex;nucleus;perinuclear region of cytoplasm;phagocytic vesicle membrane;polysome;proteinaceous extracellular matrix;sarcoplasmic reticulum lumen;smooth endoplasmic reticulum","Antigen processing and presentation;Chagas disease (American trypanosomiasis);Epstein-Barr virus infection;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human T-cell leukemia virus 1 infection;Phagosome;Protein processing in endoplasmic reticulum",null,null,16,16,16,"56.6","56.6","56.6","48.141",0,"323.31",2839100000,157,"0.447924","0.553779","0.0967264","1.18887","sp|P27797|CALR_HUMAN;tr|K7EJB9|K7EJB9_HUMAN;tr|K7EL50|K7EL50_HUMAN","sp|P27797|CALR_HUMAN;tr|K7EJB9|K7EJB9_HUMAN",828,"P27797","CALR_HUMAN","Calreticulin",null,"CALR"]
["19.5588","19.4235","20.2783","18.5126",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;gene silencing by RNA;histone mRNA metabolic process;mRNA 3'-end processing;mRNA cis splicing, via spliceosome;mRNA export from nucleus;mRNA splicing, via spliceosome;nuclear export;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of mRNA 3'-end processing;positive regulation of RNA export from nucleus;pre-mRNA cleavage required for polyadenylation;regulation of translational initiation;RNA export from nucleus;RNA metabolic process;RNA splicing;snRNA export from nucleus;snRNA transcription from RNA polymerase II promoter;termination of RNA polymerase II transcription;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","mRNA binding;RNA 7-methylguanosine cap binding;RNA binding;RNA cap binding;snRNA binding","cytoplasm;cytosol;mRNA cap binding complex;nuclear cap binding complex;nucleoplasm;nucleus;RNA cap binding complex","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,2,2,2,"14.1","14.1","14.1","18.001","0.00039825","3.3384",63606000,4,"0.0344105","0.960995","0.0956659","0.108042","sp|P52298|NCBP2_HUMAN;tr|F8WE41|F8WE41_HUMAN;tr|C9JQX9|C9JQX9_HUMAN;tr|B3KSB0|B3KSB0_HUMAN","sp|P52298|NCBP2_HUMAN;tr|F8WE41|F8WE41_HUMAN;tr|C9JQX9|C9JQX9_HUMAN;tr|B3KSB0|B3KSB0_HUMAN",1155,"P52298","NCBP2_HUMAN","Nuclear cap-binding protein subunit 2",null,"NCBP2"]
["18.5197","18.9342","18.8821","18.3821",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;cellular response to cytokine stimulus;negative regulation of cell migration;negative regulation of neuron projection development;neuron development;positive regulation of filopodium assembly;positive regulation of neuron projection development;protein homooligomerization;response to axon injury","chondroitin sulfate binding;filamin binding;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;SH3 domain binding","cell body;cytosol;exocytic vesicle;extracellular space;filamentous actin;growth cone;lamellipodium",{"$nulls":3},7,4,4,"20.4","12.6","12.6","61.963",0,"8.0518",82909000,17,"0.0980965","0.916822","0.0948067","0.291959","sp|Q14195|DPYL3_HUMAN;tr|H0YBT4|H0YBT4_HUMAN","sp|Q14195|DPYL3_HUMAN;tr|H0YBT4|H0YBT4_HUMAN",1611,"Q14195","DPYL3_HUMAN","Dihydropyrimidinase-related protein 3","RP-3","DPYSL3"]
["23.1203","24.2093","22.9948","24.1462",{"$nulls":3},"cell differentiation;cytoplasmic translation;negative regulation of apoptotic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA 5'-UTR binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic small ribosomal subunit;endoplasmic reticulum;extracellular exosome;extracellular matrix;focal adhesion;intracellular ribonucleoprotein complex;nucleolus;nucleoplasm;nucleus","Ribosome",null,null,9,9,9,"37.1","37.1","37.1","29.945",0,"141.17",2309100000,61,"0.0380401","0.957459","0.0943079","0.119021","sp|P61247|RS3A_HUMAN;tr|H0Y9Y4|H0Y9Y4_HUMAN;tr|D6RG13|D6RG13_HUMAN;tr|D6RAT0|D6RAT0_HUMAN;tr|D6R9B6|D6R9B6_HUMAN;tr|H0Y8L7|H0Y8L7_HUMAN;tr|D6RB09|D6RB09_HUMAN;tr|E9PFI5|E9PFI5_HUMAN;tr|D6RI02|D6RI02_HUMAN;tr|D6RAS7|D6RAS7_HUMAN;tr|D6RGE0|D6RGE0_HUMAN;tr|D6RED7|D6RED7_HUMAN","sp|P61247|RS3A_HUMAN;tr|H0Y9Y4|H0Y9Y4_HUMAN;tr|D6RG13|D6RG13_HUMAN;tr|D6RAT0|D6RAT0_HUMAN;tr|D6R9B6|D6R9B6_HUMAN;tr|H0Y8L7|H0Y8L7_HUMAN;tr|D6RB09|D6RB09_HUMAN;tr|E9PFI5|E9PFI5_HUMAN",1266,"P61247","RS3A_HUMAN","40S ribosomal protein S3a {ECO:0000255|HAMAP-Rule:MF_03122}",null,"RPS3A"]
["19.4385","19.3722","19.687","18.9355",{"$nulls":3},"flagellated sperm motility;fructose biosynthetic process;glucose metabolic process;glucuronate catabolic process to xylulose 5-phosphate;L-xylitol catabolic process;L-xylitol metabolic process;response to cadmium ion;response to copper ion;response to drug;response to hormone;response to nutrient levels;response to osmotic stress;sorbitol catabolic process","carbohydrate binding;D-xylulose reductase activity;identical protein binding;L-iditol 2-dehydrogenase activity;NAD binding;zinc ion binding","cytosol;extracellular exosome;extracellular space;membrane;mitochondrial membrane;motile cilium","Fructose and mannose metabolism;Metabolic pathways;Pentose and glucuronate interconversions",null,null,3,3,3,"11.8","11.8","11.8","38.324",0,"7.1594",139480000,16,"0.0828921","0.928062","0.0941286","0.249525","sp|Q00796|DHSO_HUMAN;tr|H0YLA4|H0YLA4_HUMAN;tr|H0YKB3|H0YKB3_HUMAN","sp|Q00796|DHSO_HUMAN;tr|H0YLA4|H0YLA4_HUMAN",1410,"Q00796","DHSO_HUMAN","Sorbitol dehydrogenase",null,"SORD"]
["23.814","23.7271","23.7966","23.5617",{"$nulls":3},"angiogenesis;ATP biosynthetic process;cristae formation;generation of precursor metabolites and energy;lipid metabolic process;mitochondrial ATP synthesis coupled proton transport;mitochondrion organization;negative regulation of cell adhesion involved in substrate-bound cell migration;osteoblast differentiation;positive regulation of blood vessel endothelial cell migration;proton transport;regulation of intracellular pH","angiostatin binding;ATP binding;MHC class I protein binding;proton-transporting ATP synthase activity, rotational mechanism;proton-transporting ATPase activity, rotational mechanism;transmembrane transporter activity;transporter activity","cell surface;extracellular exosome;extracellular matrix;membrane;mitochondrial matrix;mitochondrial membrane;mitochondrial nucleoid;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase, catalytic core;mitochondrion;myelin sheath;nucleus;plasma membrane;proton-transporting ATP synthase complex","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,21,21,21,"62.9","62.9","62.9","56.559",0,"323.31",3421100000,150,"0.266556","0.7554","0.091403","0.730017","sp|P06576|ATPB_HUMAN;tr|H0YH81|H0YH81_HUMAN;tr|F8W079|F8W079_HUMAN;tr|F8W0P7|F8W0P7_HUMAN;tr|H0YI37|H0YI37_HUMAN","sp|P06576|ATPB_HUMAN;tr|H0YH81|H0YH81_HUMAN;tr|F8W079|F8W079_HUMAN",529,"P06576","ATPB_HUMAN","ATP synthase subunit beta, mitochondrial",null,"ATP5B"]
["18.5602","18.3852","19.2584","17.5046",{"$nulls":3},"cell differentiation;DNA replication initiation;DNA unwinding involved in DNA replication;negative regulation of transcription, DNA-templated;nervous system development;positive regulation of cell proliferation;transcription, DNA-templated","double-stranded telomeric DNA binding;purine-rich negative regulatory element binding;RNA binding;single-stranded DNA binding;SMAD binding;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;transcription factor binding;translation repressor activity, nucleic acid binding","cytoplasm;dendrite;DNA replication factor A complex;neuronal cell body;nuclear chromosome, telomeric region;nucleus",{"$nulls":3},2,2,2,"15.2","15.2","15.2","34.91",0,"5.5083",24891000,6,"0.0329165","0.962938","0.0912104","0.103502","sp|Q00577|PURA_HUMAN","sp|Q00577|PURA_HUMAN",1405,"Q00577","PURA_HUMAN","Transcriptional activator protein Pur-alpha",null,"PURA"]
["18.7971","18.962","19.3557","18.2218",{"$nulls":9},1,1,1,"31.4","31.4","31.4","8.1418","0.0094586","1.6922",22302000,6,"0.0512721","0.949364","0.0907907","0.158466","tr|X6RHB9|X6RHB9_HUMAN;sp|Q9GZP4|PITH1_HUMAN","tr|X6RHB9|X6RHB9_HUMAN;sp|Q9GZP4|PITH1_HUMAN",2537,"X6RHB9","X6RHB9_HUMAN",null,null,"PITHD1"]
["17.6871","17.5778","17.6096","17.477",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;positive regulation of viral transcription;regulation of gene silencing by miRNA;RNA metabolic process;snRNA transcription from RNA polymerase II promoter;somatic stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;transcription, DNA-templated;transcription-coupled nucleotide-excision repair","DNA binding;DNA-directed 5'-3' RNA polymerase activity;protein dimerization activity","cytosol;DNA-directed RNA polymerase II, core complex;microtubule cytoskeleton;nucleoplasm;nucleus","Huntington disease;RNA polymerase",null,null,3,3,3,"18.2","18.2","18.2","31.441",0,"6.4572",31787000,7,"0.38887","0.634781","0.0891523","1.03762","sp|P19387|RPB3_HUMAN;tr|H3BRR2|H3BRR2_HUMAN","sp|P19387|RPB3_HUMAN",730,"P19387","RPB3_HUMAN","DNA-directed RNA polymerase II subunit RPB3 {ECO:0000305}","NA polymerase II subunit 3;NA polymerase II subunit B3","POLR2C"]
[1,"20.797","20.6198",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"8.1","8.1","8.1","10.633",0,"6.2448",25659000,5,"0.00195697","0.994609","0.0886097","0.00635829","tr|M0QZP9|M0QZP9_HUMAN;tr|M0R1W8|M0R1W8_HUMAN;tr|M0QZJ5|M0QZJ5_HUMAN;tr|M0QZT4|M0QZT4_HUMAN;sp|Q9BV35|SCMC3_HUMAN;sp|Q6KCM7|SCMC2_HUMAN","tr|M0QZP9|M0QZP9_HUMAN;tr|M0R1W8|M0R1W8_HUMAN;tr|M0QZJ5|M0QZJ5_HUMAN;tr|M0QZT4|M0QZT4_HUMAN;sp|Q9BV35|SCMC3_HUMAN;sp|Q6KCM7|SCMC2_HUMAN",1873,"M0QZP9","M0QZP9_HUMAN",null,null,"SLC25A23"]
["17.3368","16.9243","17.642","16.4427",{"$nulls":5},"membrane",{"$nulls":3},1,1,1,"23.1","23.1","23.1","11.29","0.00040048","3.3776",8433900,1,"0.044737","0.955458","0.0881987","0.139095","tr|K7ELI9|K7ELI9_HUMAN;sp|Q99470|SDF2_HUMAN","tr|K7ELI9|K7ELI9_HUMAN;sp|Q99470|SDF2_HUMAN",2374,"K7ELI9","K7ELI9_HUMAN",null,null,"SDF2"]
["22.6812","22.8433","22.9553","22.3932",{"$nulls":3},"neutrophil degranulation;response to drug;response to ethanol;response to insulin;response to zinc ion;tetrahydrofolylpolyglutamate metabolic process","exopeptidase activity;gamma-glutamyl-peptidase activity;omega peptidase activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region;extracellular space;melanosome;nucleus;specific granule lumen;tertiary granule lumen;vacuole","Antifolate resistance;Folate biosynthesis",null,null,5,5,5,"20.4","20.4","20.4","35.964",0,"46.743",743930000,34,"0.101258","0.914345","0.0879517","0.300689","sp|Q92820|GGH_HUMAN","sp|Q92820|GGH_HUMAN",2194,"Q92820","GGH_HUMAN","Gamma-glutamyl hydrolase",null,"GGH"]
["23.9023","23.8249","24.0155","23.5394",{"$nulls":4},"voltage-gated anion channel activity","mitochondrial outer membrane;mitochondrion",{"$nulls":3},11,11,11,"48.2","48.2","48.2","30.348",0,"98.582",1736100000,58,"0.122062","0.901525","0.0861835","0.357398","tr|A0A0A0MR02|A0A0A0MR02_HUMAN;sp|P45880|VDAC2_HUMAN;tr|Q5JSD2|Q5JSD2_HUMAN;tr|Q5JSD1|Q5JSD1_HUMAN;tr|A2A3S1|A2A3S1_HUMAN","tr|A0A0A0MR02|A0A0A0MR02_HUMAN;sp|P45880|VDAC2_HUMAN;tr|Q5JSD2|Q5JSD2_HUMAN;tr|Q5JSD1|Q5JSD1_HUMAN",1016,"A0A0A0MR02","A0A0A0MR02_HUMAN",null,null,"VDAC2"]
["17.377","17.7265","17.8463","17.0861",{"$nulls":3},"ribosomal protein import into nucleus;transcription factor import into nucleus","protein transporter activity;Ran GTPase binding","cytosol;fibrillar center;nuclear envelope;nucleus",{"$nulls":3},3,3,3,"2.9","2.9","2.9","112.53",0,"22.961",80391000,15,"0.0670682","0.935693","0.0855446","0.204474","sp|Q9UI26|IPO11_HUMAN;tr|E7EMB7|E7EMB7_HUMAN;tr|F8WDV0|F8WDV0_HUMAN","sp|Q9UI26|IPO11_HUMAN;tr|E7EMB7|E7EMB7_HUMAN",2846,"Q9UI26","IPO11_HUMAN","Importin-11","mp11","IPO11"]
["24.7897","24.6175","25.0835","24.1531",{"$nulls":3},"apoptotic cell clearance;blood vessel remodeling;branching involved in salivary gland morphogenesis;isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine;negative regulation of endoplasmic reticulum calcium ion concentration;positive regulation of apoptotic process;positive regulation of cell adhesion;positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of inflammatory response;positive regulation of mitochondrial calcium ion concentration;positive regulation of smooth muscle cell proliferation;protein homooligomerization;salivary gland cavitation","GTP binding;metal ion binding;protein domain specific binding;protein-glutamine gamma-glutamyltransferase activity","cytosol;endoplasmic reticulum;extracellular exosome;extracellular matrix;focal adhesion;intrinsic component of plasma membrane;mitochondrion","Huntington disease",null,null,27,27,27,"51.8","51.8","51.8","77.328",0,"323.31",10394000000,284,"0.0587323","0.943793","0.0853243","0.180333","sp|P21980|TGM2_HUMAN;tr|A2A299|A2A299_HUMAN;tr|A2A2A0|A2A2A0_HUMAN;sp|P49221|TGM4_HUMAN","sp|P21980|TGM2_HUMAN",759,"P21980","TGM2_HUMAN","Protein-glutamine gamma-glutamyltransferase 2",null,"TGM2"]
["18.5323","18.7356","18.7631","18.3346",{"$nulls":3},"oocyte development;regulation of transcription, DNA-templated;spermatogenesis;transcription from RNA polymerase II promoter;translational attenuation","DNA binding;RNA binding","cytoplasm;fibrillar center;nucleus",{"$nulls":3},6,3,3,"23.4","13.5","13.5","38.517",0,"10.12",77968000,11,"0.122562","0.902736","0.0850868","0.358746","sp|Q9Y2T7|YBOX2_HUMAN;tr|I3L2D6|I3L2D6_HUMAN","sp|Q9Y2T7|YBOX2_HUMAN",2958,"Q9Y2T7","YBOX2_HUMAN","Y-box-binding protein 2",null,"YBX2"]
["14.7372","14.5591","14.1588","14.9675",{"$nulls":4},"calcium ion binding;zinc ion binding",{"$nulls":4},2,2,2,"0.8","0.8","0.8","331.07",0,"4.5107",38752000,10,"0.0673313","0.936553","0.0849814","0.205231","sp|O43149|ZZEF1_HUMAN","sp|O43149|ZZEF1_HUMAN",229,"O43149","ZZEF1_HUMAN","Zinc finger ZZ-type and EF-hand domain-containing protein 1",null,"ZZEF1"]
["18.1663","18.1168","18.3262","17.7872",{"$nulls":3},"protein methylation","methyltransferase activity",{"$nulls":4},3,3,3,"19.6","19.6","19.6","32.693",0,"9.3103",41478000,8,"0.105907","0.913137","0.0848293","0.313469","tr|A0A087X1W2|A0A087X1W2_HUMAN;tr|E9PKG1|E9PKG1_HUMAN;sp|Q99873|ANM1_HUMAN;tr|H7C2I1|H7C2I1_HUMAN;tr|E9PNR9|E9PNR9_HUMAN;tr|E9PQ98|E9PQ98_HUMAN;tr|E9PIX6|E9PIX6_HUMAN;tr|H0YDE4|H0YDE4_HUMAN;sp|Q9NR22|ANM8_HUMAN","tr|A0A087X1W2|A0A087X1W2_HUMAN;tr|E9PKG1|E9PKG1_HUMAN;sp|Q99873|ANM1_HUMAN;tr|H7C2I1|H7C2I1_HUMAN",3062,"A0A087X1W2","A0A087X1W2_HUMAN",null,null,"PRMT1"]
["18.2519","18.5186","18.5121","18.0893",{"$nulls":3},"activation of MAPKK activity;cellular response to cAMP;cellular response to drug;cellular response to glucose stimulus;cellular response to nerve growth factor stimulus;establishment of endothelial barrier;liver regeneration;negative regulation of collagen biosynthetic process;negative regulation of synaptic vesicle exocytosis;nerve growth factor signaling pathway;neutrophil degranulation;positive regulation of ERK1 and ERK2 cascade;positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;positive regulation of glucose import;positive regulation of GTPase activity;positive regulation of neuron projection development;positive regulation of protein kinase activity;positive regulation of vasculogenesis;protein transport;Rap protein signal transduction;regulation of cell junction assembly;regulation of insulin secretion;response to antineoplastic agent;signal transduction","GTP binding;GTPase activity;protein complex binding;protein transporter activity;Rap guanyl-nucleotide exchange factor activity","cell junction;cytoplasm;cytosol;early endosome;extracellular exosome;guanyl-nucleotide exchange factor complex;late endosome;myelin sheath;neuron projection;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;specific granule membrane","cAMP signaling pathway;Chemokine signaling pathway;Cushing syndrome;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;MAPK signaling pathway;Neurotrophin signaling pathway;Pancreatic secretion;Platelet activation;Rap1 signaling pathway;Ras signaling pathway;Renal cell carcinoma;Tight junction",null,null,6,1,1,"31.5","7.1","7.1","20.987","0.0075708","1.7538",30824000,1,"0.115092","0.904042","0.0846128","0.338533","sp|P62834|RAP1A_HUMAN;tr|A0A075B6Q0|A0A075B6Q0_HUMAN","sp|P62834|RAP1A_HUMAN;tr|A0A075B6Q0|A0A075B6Q0_HUMAN",1318,"P62834","RAP1A_HUMAN","Ras-related protein Rap-1A",null,"RAP1A"]
["19.2648","19.4613","19.244","19.3138",{"$nulls":4},"GTP binding",{"$nulls":4},3,2,2,"7.5","5.9","5.9","49.355","0.0020891","2.218",104400000,1,"0.297207","0.733973","0.0841293","0.806914","tr|A0A087X142|A0A087X142_HUMAN;tr|A6NMH6|A6NMH6_HUMAN;tr|A6NFQ9|A6NFQ9_HUMAN;tr|F8W8I8|F8W8I8_HUMAN;sp|Q92599|SEPT8_HUMAN;tr|A0A0A0MRP8|A0A0A0MRP8_HUMAN;tr|C9J4G8|C9J4G8_HUMAN;tr|C9JV02|C9JV02_HUMAN","tr|A0A087X142|A0A087X142_HUMAN;tr|A6NMH6|A6NMH6_HUMAN;tr|A6NFQ9|A6NFQ9_HUMAN;tr|F8W8I8|F8W8I8_HUMAN;sp|Q92599|SEPT8_HUMAN",2177,"A0A087X142","A0A087X142_HUMAN",null,null,"SEPT8"]
["20.1174","19.2362","20.4563","18.7338",{"$nulls":3},"cellular response to oxidative stress;chaperone-mediated protein complex assembly;oxidation-dependent protein catabolic process;protein quality control for misfolded or incompletely synthesized proteins;regulation of mitochondrial DNA replication","ATP binding;ATP-dependent peptidase activity;sequence-specific DNA binding;serine-type endopeptidase activity","cytosol;mitochondrial matrix;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},10,10,10,"23.9","23.9","23.9","93.296",0,"202.01",277290000,34,"0.0267101","0.967485","0.0817528","0.0845072","tr|K7EJE8|K7EJE8_HUMAN;tr|K7EKE6|K7EKE6_HUMAN;sp|P36776|LONM_HUMAN;tr|K7ERR6|K7ERR6_HUMAN;tr|K7EQF8|K7EQF8_HUMAN;tr|K7ER27|K7ER27_HUMAN","tr|K7EJE8|K7EJE8_HUMAN;tr|K7EKE6|K7EKE6_HUMAN;sp|P36776|LONM_HUMAN",947,"K7EJE8","K7EJE8_HUMAN","Lon protease homolog, mitochondrial {ECO:0000256|HAMAP-Rule:MF_03120}"]
["17.0165","17.0056","17.5013","16.3581",{"$nulls":3},"carbohydrate metabolic process;cellular protein modification process;CMP-N-acetylneuraminate transport","CMP-N-acetylneuraminate transmembrane transporter activity;sugar:proton symporter activity","Golgi apparatus;Golgi membrane;integral component of plasma membrane",{"$nulls":3},1,1,1,"4.2","4.2","4.2","36.778",0,"16.908",16099000,1,"0.0458155","0.956114","0.0813456","0.142306","sp|P78382|S35A1_HUMAN","sp|P78382|S35A1_HUMAN",1370,"P78382","S35A1_HUMAN","CMP-sialic acid transporter","MP-SA-Tr;MP-Sia-Tr","SLC35A1"]
["19.746","20.0538","19.963","19.6773",{"$nulls":4},"RNA binding",{"$nulls":4},5,5,5,"9.8","9.8","9.8","63.472",0,"87.953",225870000,19,"0.130364","0.898738","0.0797243","0.379709","sp|Q8N1G4|LRC47_HUMAN","sp|Q8N1G4|LRC47_HUMAN",2038,"Q8N1G4","LRC47_HUMAN","Leucine-rich repeat-containing protein 47",null,"LRRC47"]
["18.8946","18.6602","19.3268","18.0693",{"$nulls":4},"GTP binding","septin complex",{"$nulls":3},5,2,2,"17.6","11.1","11.1","49.303",0,"74.363",94653000,18,"0.0396921","0.95579","0.0793028","0.123995","tr|B1AMS2|B1AMS2_HUMAN;sp|Q14141|SEPT6_HUMAN","tr|B1AMS2|B1AMS2_HUMAN;sp|Q14141|SEPT6_HUMAN",1602,"B1AMS2","B1AMS2_HUMAN"]
["28.3855","28.209","28.48","27.9563",{"$nulls":3},"angiogenesis;body fluid secretion;catabolism by host of symbiont protein;collagen fibril organization;fibrinolysis;interleukin-12-mediated signaling pathway;membrane raft assembly;negative regulation by host of symbiont molecular function;negative regulation of development of symbiont involved in interaction with host;negative regulation of low-density lipoprotein particle receptor catabolic process;neutrophil degranulation;osteoclast development;positive regulation of fibroblast proliferation;positive regulation of low-density lipoprotein particle clearance;positive regulation of low-density lipoprotein particle receptor binding;positive regulation of low-density lipoprotein receptor activity;positive regulation of protein phosphorylation;positive regulation of receptor recycling;positive regulation of receptor-mediated endocytosis involved in cholesterol transport;positive regulation of vacuole organization;positive regulation of vesicle fusion;protein heterotetramerization;protein localization to plasma membrane;response to thyroid hormone;vesicle budding from membrane","bone sialoprotein binding;cadherin binding involved in cell-cell adhesion;calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;cytoskeletal protein binding;identical protein binding;molecular function regulator;phosphatidylinositol-4,5-bisphosphate binding;phospholipase A2 inhibitor activity;protease binding;Rab GTPase binding;RNA binding;S100 protein binding","azurophil granule lumen;basement membrane;basolateral plasma membrane;cell cortex;cell surface;cell-cell adherens junction;cytoplasm;cytosol;early endosome;endosome;extracellular exosome;extracellular matrix;extracellular region;extracellular space;extrinsic component of plasma membrane;late endosome membrane;lipid droplet;lysosomal membrane;macropinosome;melanosome;membrane;membrane raft;midbody;myelin sheath adaxonal region;nucleus;PCSK9-AnxA2 complex;perinuclear region of cytoplasm;plasma membrane;ruffle;sarcolemma;Schmidt-Lanterman incisure;vesicle",{"$nulls":3},28,28,28,"71.1","71.1","71.1","38.604",0,"323.31",79793000000,416,"0.0960286","0.918679","0.0790863","0.286233","sp|P07355|ANXA2_HUMAN;tr|H0YN42|H0YN42_HUMAN;tr|H0YMD0|H0YMD0_HUMAN;tr|H0YMU9|H0YMU9_HUMAN;tr|H0YM50|H0YM50_HUMAN;sp|A6NMY6|AXA2L_HUMAN;tr|H0YNP5|H0YNP5_HUMAN;tr|H0YN28|H0YN28_HUMAN;tr|H0YL33|H0YL33_HUMAN;tr|H0YKS4|H0YKS4_HUMAN;tr|H0YMM1|H0YMM1_HUMAN;tr|H0YKZ7|H0YKZ7_HUMAN;tr|H0YLV6|H0YLV6_HUMAN;tr|H0YMT9|H0YMT9_HUMAN;tr|H0YKX9|H0YKX9_HUMAN;tr|H0YKL9|H0YKL9_HUMAN;tr|H0YMW4|H0YMW4_HUMAN;tr|H0YNA0|H0YNA0_HUMAN;tr|H0YKV8|H0YKV8_HUMAN;tr|H0YMD9|H0YMD9_HUMAN;tr|H0YNB8|H0YNB8_HUMAN;tr|H0YN52|H0YN52_HUMAN;tr|H0YKN4|H0YKN4_HUMAN;tr|H0YLE2|H0YLE2_HUMAN","sp|P07355|ANXA2_HUMAN;tr|H0YN42|H0YN42_HUMAN;tr|H0YMD0|H0YMD0_HUMAN;tr|H0YMU9|H0YMU9_HUMAN;tr|H0YM50|H0YM50_HUMAN;sp|A6NMY6|AXA2L_HUMAN;tr|H0YNP5|H0YNP5_HUMAN;tr|H0YN28|H0YN28_HUMAN;tr|H0YL33|H0YL33_HUMAN;tr|H0YKS4|H0YKS4_HUMAN",542,"P07355","ANXA2_HUMAN","Annexin A2",null,"ANXA2"]
["22.7103","22.7499","22.4906","22.813",{"$nulls":9},4,3,3,"29.4","20.3","20.3","19.997",0,"4.4105",515160000,9,"0.169138","0.851824","0.0782757","0.481951","tr|H0YN26|H0YN26_HUMAN;sp|P39687|AN32A_HUMAN;sp|O43423|AN32C_HUMAN;sp|O95626|AN32D_HUMAN","tr|H0YN26|H0YN26_HUMAN;sp|P39687|AN32A_HUMAN;sp|O43423|AN32C_HUMAN",965,"H0YN26","H0YN26_HUMAN",null,null,"ANP32A"]
["14.8162","15.0994","15.4068","14.3539",{"$nulls":5},"bicellular tight junction;nucleus;plasma membrane","Tight junction",null,null,2,2,2,"3.2","3.2","3.2","101.4",0,"12.358",15099000,5,"0.0457247","0.956097","0.0774326","0.142036","sp|O95049|ZO3_HUMAN","sp|O95049|ZO3_HUMAN",408,"O95049","ZO3_HUMAN","Tight junction protein ZO-3",null,"TJP3"]
["20.5431","20.816","20.6971","20.5076",{"$nulls":3},"endoplasmic reticulum organization;positive regulation of ATPase activity;protein localization to nuclear envelope","ATPase activator activity;ATPase binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;nuclear membrane",{"$nulls":3},7,7,7,"25.5","25.5","25.5","51.263",0,"66.937",367720000,33,"0.162624","0.862555","0.0772533","0.464972","sp|Q8NFQ8|TOIP2_HUMAN","sp|Q8NFQ8|TOIP2_HUMAN",2096,"Q8NFQ8","TOIP2_HUMAN","Torsin-1A-interacting protein 2",null,"TOR1AIP2"]
["22.2598","22.3045","22.2561","22.1547",{"$nulls":3},"translation","structural constituent of ribosome","small ribosomal subunit",{"$nulls":3},7,7,7,"45.2","45.2","45.2","29.404",0,"35.098",572460000,32,"0.522677","0.501667","0.076745","1.38567","tr|C9J9K3|C9J9K3_HUMAN;sp|P08865|RSSA_HUMAN;tr|A0A0C4DG17|A0A0C4DG17_HUMAN;tr|A6NE09|A6NE09_HUMAN;tr|F8WD59|F8WD59_HUMAN;tr|C9JQR9|C9JQR9_HUMAN","tr|C9J9K3|C9J9K3_HUMAN;sp|P08865|RSSA_HUMAN;tr|A0A0C4DG17|A0A0C4DG17_HUMAN;tr|A6NE09|A6NE09_HUMAN;tr|F8WD59|F8WD59_HUMAN",573,"C9J9K3","C9J9K3_HUMAN",null,null,"RPSA"]
["18.6716","18.5234","19.4544","17.5891",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome",{"$nulls":3},2,2,2,"16.3","16.3","16.3","19.198",0,"15.656",48776000,12,"0.025577","0.968851","0.0757971","0.0810151","sp|Q13405|RM49_HUMAN;tr|E9PI78|E9PI78_HUMAN;tr|H0YDP7|H0YDP7_HUMAN;tr|E9PNF1|E9PNF1_HUMAN","sp|Q13405|RM49_HUMAN;tr|E9PI78|E9PI78_HUMAN;tr|H0YDP7|H0YDP7_HUMAN;tr|E9PNF1|E9PNF1_HUMAN",1548,"Q13405","RM49_HUMAN","39S ribosomal protein L49, mitochondrial","49mt;RP-L49","MRPL49"]
["22.164","22.2955","22.3431","21.9654",{"$nulls":3},"cell proliferation;cellular response to antibiotic;cellular response to UV-B;heart development;immune response;intrinsic apoptotic signaling pathway in response to DNA damage;prostate gland stromal morphogenesis;regulation of gene expression;response to organic substance;response to zinc ion","AT DNA binding;DNA binding, bending;peptide binding;zinc ion binding","cytoplasm",{"$nulls":3},1,1,1,"9.1","9.1","9.1","8.5328","0.0094678","1.6982",198250000,7,"0.129561","0.89849","0.0755062","0.377558","sp|P50238|CRIP1_HUMAN","sp|P50238|CRIP1_HUMAN",1109,"P50238","CRIP1_HUMAN","Cysteine-rich protein 1","RP-1","CRIP1"]
["19.5272","19.8365","19.3103","19.9031",{"$nulls":3},"endosomal transport;intracellular protein transport;macroautophagy;membrane organization;multivesicular body assembly;negative regulation of epidermal growth factor receptor signaling pathway;protein deubiquitination",null,"cytoplasm;cytosol;early endosome membrane;ESCRT-0 complex;intracellular membrane-bounded organelle;nucleoplasm","Endocytosis;Jak-STAT signaling pathway",null,null,3,3,2,7,7,"5.1","58.164",0,"4.2555",286150000,10,"0.0741495","0.931423","0.0751371","0.224754","sp|O75886|STAM2_HUMAN","sp|O75886|STAM2_HUMAN",375,"O75886","STAM2_HUMAN","Signal transducing adapter molecule 2","TAM-2","STAM2"]
["16.7807","16.4007","15.9222","17.1097",{"$nulls":3},"cellular copper ion homeostasis;cytoplasmic sequestering of NF-kappaB;Golgi to plasma membrane transport;negative regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;post-translational protein modification;protein transport;protein ubiquitination","cullin family protein binding","cytosol;endosome;nucleoplasm",{"$nulls":3},2,2,2,"5.3","5.3","5.3","70.755",0,"3.8515",37999000,3,"0.038341","0.957278","0.0747662","0.119928","sp|O60826|CCD22_HUMAN","sp|O60826|CCD22_HUMAN",308,"O60826","CCD22_HUMAN","Coiled-coil domain-containing protein 22",null,"CCDC22"]
["20.8339","20.6527","20.8466","20.4911",{"$nulls":3},"cellular response to leukemia inhibitory factor;methylation;one-carbon metabolic process;protein heterooligomerization;protein hexamerization;S-adenosylmethionine biosynthetic process","ATP binding;identical protein binding;metal ion binding;methionine adenosyltransferase activity","cytosol;methionine adenosyltransferase complex","Biosynthesis of amino acids;Cysteine and methionine metabolism;Metabolic pathways",null,null,5,5,5,"18.5","18.5","18.5","43.66",0,"16.784",333540000,27,"0.127962","0.897004","0.0744667","0.373272","sp|P31153|METK2_HUMAN;sp|Q00266|METK1_HUMAN","sp|P31153|METK2_HUMAN",884,"P31153","METK2_HUMAN","S-adenosylmethionine synthase isoform type-2","doMet synthase 2","MAT2A"]
["18.5789","18.1771","18.3705","18.2369",{"$nulls":3},"cardiac left ventricle morphogenesis;cellular response to insulin stimulus;cellular response to interleukin-3;chemical synaptic transmission, postsynaptic;dopamine receptor signaling pathway;extrinsic apoptotic signaling pathway in absence of ligand;glycogen metabolic process;insulin receptor signaling pathway;IRE1-mediated unfolded protein response;negative regulation of canonical Wnt signaling pathway;negative regulation of cell growth involved in cardiac muscle cell development;negative regulation of glucose import;negative regulation of glycogen (starch) synthase activity;negative regulation of glycogen biosynthetic process;negative regulation of glycogen synthase activity, transferring glucose-1-phosphate;negative regulation of insulin receptor signaling pathway;negative regulation of TOR signaling;negative regulation of type B pancreatic cell development;negative regulation of UDP-glucose catabolic process;nervous system development;peptidyl-threonine phosphorylation;positive regulation of adrenergic receptor signaling pathway;positive regulation of amyloid-beta formation;positive regulation of cAMP biosynthetic process;positive regulation of gene expression;positive regulation of glycogen (starch) synthase activity;positive regulation of heart contraction;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein catabolic process;positive regulation of protein targeting to mitochondrion;positive regulation of protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;protein phosphorylation;regulation of apoptotic process;regulation of autophagy of mitochondrion;regulation of systemic arterial blood pressure;Wnt signaling pathway","ATP binding;protein kinase A catalytic subunit binding;protein serine/threonine kinase activity;receptor binding;tau-protein kinase activity","apical dendrite;beta-catenin destruction complex;cytosol;mitochondrion;neuronal cell body;postsynapse;proximal dendrite","Chemokine signaling pathway;Dopaminergic synapse;Non-alcoholic fatty liver disease (NAFLD)",null,null,3,3,3,"17.2","17.2","17.2","50.98",0,"7.3773",67636000,16,"0.119764","0.902772","0.0743408","0.351191","sp|P49840|GSK3A_HUMAN;tr|A8MT37|A8MT37_HUMAN;tr|M0QYV0|M0QYV0_HUMAN","sp|P49840|GSK3A_HUMAN;tr|A8MT37|A8MT37_HUMAN",1100,"P49840","GSK3A_HUMAN","Glycogen synthase kinase-3 alpha","SK-3 alpha","GSK3A"]
["22.8965","22.176","22.857","22.0683",{"$nulls":3},"translational initiation;transmembrane transport","cadherin binding;GTP binding;GTPase activity;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2 complex;extracellular exosome","RNA transport",null,null,12,12,12,"36.4","36.4","36.4","51.109",0,"38.046",1291400000,58,"0.0443336","0.955108","0.0736504","0.137892","sp|P41091|IF2G_HUMAN;sp|Q2VIR3|IF2GL_HUMAN;tr|F8W810|F8W810_HUMAN;tr|H7BZU1|H7BZU1_HUMAN","sp|P41091|IF2G_HUMAN;sp|Q2VIR3|IF2GL_HUMAN;tr|F8W810|F8W810_HUMAN",979,"P41091","IF2G_HUMAN","Eukaryotic translation initiation factor 2 subunit 3",null,"EIF2S3"]
["20.4149","20.4608","20.6087","20.1207",{"$nulls":3},"L-phenylalanine catabolic process;positive regulation of transcription, DNA-templated;protein heterooligomerization;protein homotetramerization;regulation of protein homodimerization activity;tetrahydrobiopterin biosynthetic process;transcription, DNA-templated","4-alpha-hydroxytetrahydrobiopterin dehydratase activity;identical protein binding;phenylalanine 4-monooxygenase activity;transcription coactivator activity","cytosol;extracellular exosome;nucleoplasm;nucleus","Folate biosynthesis;Metabolic pathways",null,null,2,2,2,25,25,25,"11.999","0.0011107","2.7248",81667000,2,"0.100458","0.914118","0.0731525","0.298482","sp|P61457|PHS_HUMAN","sp|P61457|PHS_HUMAN",1272,"P61457","PHS_HUMAN","Pterin-4-alpha-carbinolamine dehydratase","HS","PCBD1"]
["15.2124","15.724","16.2885","14.5035",{"$nulls":4},"RNA binding",{"$nulls":4},2,2,2,"2.7","2.7","2.7","85.576","0.0072799","1.7997",11906000,2,"0.024543","0.970615","0.0722528","0.0778217","tr|B7WP74|B7WP74_HUMAN;sp|Q9HCG8|CWC22_HUMAN","tr|B7WP74|B7WP74_HUMAN;sp|Q9HCG8|CWC22_HUMAN",2644,"B7WP74","B7WP74_HUMAN",null,null,"CWC22"]
["17.056",1,1,"16.9116",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"3.3","3.3","3.3","31.826","0.0014089","2.3148",14608000,3,"0.00196645","0.994739","0.0722113","0.00638904","sp|Q96B21|TM45B_HUMAN","sp|Q96B21|TM45B_HUMAN",2234,"Q96B21","TM45B_HUMAN","Transmembrane protein 45B",null,"TMEM45B"]
["22.952","22.8403","23.0246","22.6268",{"$nulls":3},"ATP metabolic process;cellular heat acclimation;cellular response to heat;cellular response to oxidative stress;mRNA catabolic process;negative regulation of apoptotic process;negative regulation of cell death;negative regulation of cell growth;negative regulation of cell proliferation;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;negative regulation of inclusion body assembly;negative regulation of protein ubiquitination;neutrophil degranulation;positive regulation of gene expression;positive regulation of interleukin-8 production;positive regulation of microtubule nucleation;positive regulation of NF-kappaB transcription factor activity;positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;positive regulation of tumor necrosis factor-mediated signaling pathway;protein refolding;protein stabilization;regulation of cellular response to heat;regulation of mitotic spindle assembly;regulation of protein ubiquitination","ATP binding;ATPase activity;ATPase activity, coupled;C3HC4-type RING finger domain binding;enzyme binding;G-protein coupled receptor binding;heat shock protein binding;histone deacetylase binding;protein binding involved in protein folding;protein N-terminus binding;receptor binding;RNA binding;ubiquitin protein ligase binding;unfolded protein binding;virus receptor activity","aggresome;blood microparticle;centriole;centrosome;cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;inclusion body;intracellular ribonucleoprotein complex;mitochondrion;nuclear speck;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex;vesicle","Antigen processing and presentation;Endocytosis;Estrogen signaling pathway;Legionellosis;Longevity regulating pathway - multiple species;MAPK signaling pathway;Measles;Prion diseases;Protein processing in endoplasmic reticulum;Spliceosome;Toxoplasmosis",null,null,17,16,7,"42.7","40.7","20.3","70.051",0,"295.56",2240400000,119,"0.116012","0.903554","0.0704565","0.34103","sp|P0DMV9|HS71B_HUMAN;sp|P0DMV8|HS71A_HUMAN;tr|A0A0G2JIW1|A0A0G2JIW1_HUMAN;tr|V9GZ37|V9GZ37_HUMAN","sp|P0DMV9|HS71B_HUMAN;sp|P0DMV8|HS71A_HUMAN;tr|A0A0G2JIW1|A0A0G2JIW1_HUMAN;tr|V9GZ37|V9GZ37_HUMAN",602,"P0DMV9","HS71B_HUMAN","Heat shock 70 kDa protein 1B {ECO:0000312|HGNC:HGNC:5233}",null,"HSPA1B"]
["19.9024","19.7998","19.863","19.6988",{"$nulls":3},"carnitine shuttle;fatty acid beta-oxidation;regulation of lipid metabolic process","carnitine O-palmitoyltransferase activity","mitochondrial inner membrane;mitochondrion;nucleolus;nucleoplasm","Fatty acid degradation;Fatty acid metabolism;PPAR signaling pathway;Thermogenesis",null,null,5,5,5,"10.2","10.2","10.2","73.776",0,"16.091",279880000,31,"0.264745","0.756346","0.0702286","0.725466","sp|P23786|CPT2_HUMAN","sp|P23786|CPT2_HUMAN",785,"P23786","CPT2_HUMAN","Carnitine O-palmitoyltransferase 2, mitochondrial",null,"CPT2"]
["18.5666","15.7389","18.388","15.7785",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;mRNA splicing, via spliceosome;mRNA stabilization;multicellular organism development;negative regulation of gene silencing by miRNA;positive regulation of translation;regulation of mRNA stability;regulation of stem cell population maintenance","AU-rich element binding;double-stranded RNA binding;mRNA 3'-UTR AU-rich region binding;mRNA 3'-UTR binding;mRNA binding;protein homodimerization activity;protein kinase binding;RNA binding","cytoplasm;cytosol;membrane;nucleoplasm;nucleus;ribonucleoprotein complex","AMPK signaling pathway;IL-17 signaling pathway",null,null,2,2,2,"8.9","8.9","8.9","36.091",0,"4.8942",35143000,4,"0.0112281","0.983523","0.0694642","0.0361059","sp|Q15717|ELAV1_HUMAN;tr|M0QZR9|M0QZR9_HUMAN","sp|Q15717|ELAV1_HUMAN;tr|M0QZR9|M0QZR9_HUMAN",1718,"Q15717","ELAV1_HUMAN","ELAV-like protein 1",null,"ELAVL1"]
["22.8238","22.9552","23.2897","22.3518",{"$nulls":3},"angiogenesis;branching morphogenesis of an epithelial tube;cell differentiation;cellular response to calcium ion;chloride transmembrane transport;chloride transport;endothelial cell morphogenesis;establishment or maintenance of apical/basal cell polarity;fertilization;keratinocyte differentiation;multicellular organism growth;negative regulation of cell migration;regulation of cytoskeleton organization;regulation of ion transmembrane transport;retina vasculature morphogenesis in camera-type eye;vacuolar acidification","chloride channel activity;voltage-gated ion channel activity","actin cytoskeleton;apical part of cell;cell surface;cell-cell junction;centrosome;chloride channel complex;cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;intracellular;microvillus;midbody;mitochondrion;nuclear matrix;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},7,7,7,"37.2","37.2","37.2","28.772",0,"279.01",1007900000,55,"0.0467996","0.955135","0.0687704","0.145232","sp|Q9Y696|CLIC4_HUMAN","sp|Q9Y696|CLIC4_HUMAN",3042,"Q9Y696","CLIC4_HUMAN","Chloride intracellular channel protein 4",null,"CLIC4"]
["14.4108","16.1297","15.8177","14.5865",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitinyl hydrolase activity","cytosol;plasma membrane",{"$nulls":3},2,2,2,"3.5","3.5","3.5","69.447","0.00040355","3.4297",17029000,4,"0.0202293","0.974336","0.0681138","0.0644297","tr|H7C189|H7C189_HUMAN;sp|Q13107|UBP4_HUMAN","tr|H7C189|H7C189_HUMAN;sp|Q13107|UBP4_HUMAN",1520,"H7C189","H7C189_HUMAN",null,null,"USP4"]
["14.3443","14.6202","15.0609","13.7695",{"$nulls":3},"cell adhesion;cell migration;cellular protein metabolic process;endoderm development;extracellular matrix disassembly;extracellular matrix organization;hemidesmosome assembly;positive regulation of epithelial cell proliferation;post-translational protein modification;protein complex assembly;substrate adhesion-dependent cell spreading","extracellular matrix structural constituent","basement membrane;endoplasmic reticulum lumen;extracellular exosome;extracellular matrix;extracellular region;extracellular space;laminin-1 complex;laminin-10 complex;laminin-11 complex","Amoebiasis;ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Pathways in cancer;PI3K-Akt signaling pathway;Prion diseases;Small cell lung cancer;Toxoplasmosis",null,null,3,3,3,3,3,3,"177.6",0,"3.6829",29982000,4,"0.0322565","0.963262","0.0670114","0.101493","sp|P11047|LAMC1_HUMAN","sp|P11047|LAMC1_HUMAN",615,"P11047","LAMC1_HUMAN","Laminin subunit gamma-1",null,"LAMC1"]
["21.7501","21.5355","21.8273","21.3257",{"$nulls":3},"cell differentiation;nervous system development",null,"cytoplasm;cytosol;microtubule;microtubule cytoskeleton",{"$nulls":3},9,9,9,"40.6","40.6","40.6","27.325",0,"82.155",585840000,45,"0.0805843","0.928062","0.0662975","0.243014","sp|Q99426|TBCB_HUMAN;tr|K7EP07|K7EP07_HUMAN;tr|K7EK42|K7EK42_HUMAN;tr|K7EL99|K7EL99_HUMAN;tr|K7EQH0|K7EQH0_HUMAN;tr|K7ER04|K7ER04_HUMAN","sp|Q99426|TBCB_HUMAN;tr|K7EP07|K7EP07_HUMAN;tr|K7EK42|K7EK42_HUMAN",2368,"Q99426","TBCB_HUMAN","Tubulin-folding cofactor B",null,"TBCB"]
["15.5528","15.4801","16.4497","14.4519",{"$nulls":3},"endocytosis",{"$nulls":5},1,1,1,"3.5","3.5","3.5","51.232","0.0010707","2.3892",10602000,2,"0.0206402","0.974461","0.0656819","0.0657104","tr|A0A075B6Q2|A0A075B6Q2_HUMAN;sp|Q5T0N5|FBP1L_HUMAN;tr|S4R347|S4R347_HUMAN","tr|A0A075B6Q2|A0A075B6Q2_HUMAN;sp|Q5T0N5|FBP1L_HUMAN;tr|S4R347|S4R347_HUMAN",1827,"A0A075B6Q2","A0A075B6Q2_HUMAN",null,null,"FNBP1L"]
["20.249",1,"20.1188",1,{"$nulls":3},"G-protein coupled receptor signaling pathway","G-protein beta/gamma-subunit complex binding;GTPase activity;guanyl nucleotide binding;signal transducer activity",{"$nulls":4},1,1,1,"20.8","20.8","20.8","8.0493","0.00039448","3.2759",28110000,5,"0.00147579","0.995604","0.0650797","0.00479756","tr|A0A087WVZ3|A0A087WVZ3_HUMAN;tr|K7EL62|K7EL62_HUMAN;sp|P29992|GNA11_HUMAN","tr|A0A087WVZ3|A0A087WVZ3_HUMAN;tr|K7EL62|K7EL62_HUMAN;sp|P29992|GNA11_HUMAN",852,"A0A087WVZ3","A0A087WVZ3_HUMAN",null,null,"GNA11"]
["20.7807","20.804","20.9678","20.4876",{"$nulls":3},"COPII vesicle coating;ER to Golgi vesicle-mediated transport;Golgi organization;Golgi vesicle docking;intracellular protein transport;membrane fusion;transcytosis;vesicle fusion with Golgi apparatus","cadherin binding;protein transporter activity;RNA binding","cytosol;endoplasmic reticulum;ER to Golgi transport vesicle membrane;fibrillar center;Golgi apparatus;Golgi membrane;Golgi stack;membrane;perinuclear region of cytoplasm;transport vesicle",{"$nulls":3},14,14,14,"21.9","21.9","21.9","107.89",0,"152.4",720610000,52,"0.0898248","0.921569","0.064662","0.26897","sp|O60763|USO1_HUMAN","sp|O60763|USO1_HUMAN",304,"O60763","USO1_HUMAN","General vesicular transport factor p115",null,"USO1"]
["19.5158","19.2687","19.858","18.7997",{"$nulls":3},"DNA repair;mitotic sister chromatid cohesion","ATP binding;chromatin binding","cohesin complex;cytosol;nucleoplasm",{"$nulls":3},10,10,10,10,10,10,"140.86",0,"21.408",440520000,33,"0.0373016","0.957339","0.0634632","0.116793","tr|G8JLG1|G8JLG1_HUMAN;sp|Q14683|SMC1A_HUMAN;tr|H0Y7K8|H0Y7K8_HUMAN;tr|V9GY57|V9GY57_HUMAN","tr|G8JLG1|G8JLG1_HUMAN;sp|Q14683|SMC1A_HUMAN",1637,"G8JLG1","G8JLG1_HUMAN","Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719}",null,"SMC1A"]
["18.1444","18.4815","17.7584","18.7405",{"$nulls":3},"mitochondrial translation","structural constituent of ribosome","mitochondrial large ribosomal subunit",{"$nulls":3},1,1,1,30,30,30,"11.681",0,"4.5558",18599000,9,"0.0390961","0.956583","0.0634422","0.122202","tr|G5E9P5|G5E9P5_HUMAN;sp|Q86TS9|RM52_HUMAN","tr|G5E9P5|G5E9P5_HUMAN;sp|Q86TS9|RM52_HUMAN",1973,"G5E9P5","G5E9P5_HUMAN",null,null,"MRPL52"]
["15.9449","16.0271","16.0557","15.7917",{"$nulls":5},"centrosome;cytosol;nuclear membrane",{"$nulls":3},2,2,2,"1.9","1.9","1.9","171.97",0,"34.346",52805000,5,"0.157167","0.868606","0.062294","0.450691","tr|H0Y2V6|H0Y2V6_HUMAN;sp|Q5SW79|CE170_HUMAN","tr|H0Y2V6|H0Y2V6_HUMAN;sp|Q5SW79|CE170_HUMAN",1824,"H0Y2V6","H0Y2V6_HUMAN",null,null,"CEP170"]
["21.4211","21.5682","21.693","21.1722",{"$nulls":5},"nucleoplasm",{"$nulls":3},2,2,2,"34.4","34.4","34.4","10.279",0,"41.997",159290000,16,"0.0757558","0.930774","0.0620508","0.229327","tr|V9GZ59|V9GZ59_HUMAN;sp|P61964|WDR5_HUMAN;tr|V9GYQ5|V9GYQ5_HUMAN","tr|V9GZ59|V9GZ59_HUMAN;sp|P61964|WDR5_HUMAN;tr|V9GYQ5|V9GYQ5_HUMAN",1283,"V9GZ59","V9GZ59_HUMAN",null,null,"WDR5"]
["21.366","21.3597","21.3335","21.2696",{"$nulls":3},"positive regulation of exoribonuclease activity;regulation of transcription, DNA-templated;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair","DNA binding;zinc ion binding","nucleolus;nucleoplasm;nucleus;transcription factor TFIID complex",{"$nulls":3},8,8,8,"30.2","30.2","30.2","33.969",0,"55.671",439550000,30,"0.707298","0.363088","0.0612936","1.91081","sp|P23193|TCEA1_HUMAN;tr|E5RIS7|E5RIS7_HUMAN;tr|E5RJ93|E5RJ93_HUMAN;tr|B7Z4S1|B7Z4S1_HUMAN;tr|A0A0A0MT58|A0A0A0MT58_HUMAN;sp|Q15560|TCEA2_HUMAN;tr|Q5JRI7|Q5JRI7_HUMAN","sp|P23193|TCEA1_HUMAN;tr|E5RIS7|E5RIS7_HUMAN",771,"P23193","TCEA1_HUMAN","Transcription elongation factor A protein 1",null,"TCEA1"]
["18.8054","18.9606","19.2741","18.3732",{"$nulls":3},"cellular response to DNA damage stimulus;DNA damage response, detection of DNA damage;DNA repair;global genome nucleotide-excision repair;histone H2A monoubiquitination;interaction with symbiont;negative regulation of apoptotic process;nucleotide-excision repair;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;positive regulation by virus of viral protein levels in host cell;positive regulation of protein catabolic process;positive regulation of viral genome replication;positive regulation of viral release from host cell;post-translational protein modification;proteasomal protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of mitotic cell cycle phase transition;transcription-coupled nucleotide-excision repair;UV-damage excision repair;viral process;Wnt signaling pathway","cullin family protein binding;damaged DNA binding;DNA binding;protein binding, bridging;protein complex binding;WD40-repeat domain binding","Cul4A-RING E3 ubiquitin ligase complex;Cul4B-RING E3 ubiquitin ligase complex;Cul4-RING E3 ubiquitin ligase complex;cytoplasm;extracellular exosome;extracellular space;nuclear chromosome, telomeric region;nucleoplasm;nucleus;protein complex","Hepatitis B;Human immunodeficiency virus 1 infection;Nucleotide excision repair;Ubiquitin mediated proteolysis;Viral carcinogenesis",null,null,7,7,7,"9.6","9.6","9.6","126.97",0,"75.85",248810000,26,"0.0416554","0.955009","0.0593719","0.129887","sp|Q16531|DDB1_HUMAN;tr|F5GY55|F5GY55_HUMAN;tr|F5H581|F5H581_HUMAN;tr|F8WF81|F8WF81_HUMAN;tr|F5H198|F5H198_HUMAN;tr|F5H2L3|F5H2L3_HUMAN;tr|F5GZ34|F5GZ34_HUMAN;tr|F5H0Y5|F5H0Y5_HUMAN;tr|F5H775|F5H775_HUMAN;tr|F5H4N9|F5H4N9_HUMAN;tr|F5H6C5|F5H6C5_HUMAN;tr|F5H238|F5H238_HUMAN","sp|Q16531|DDB1_HUMAN;tr|F5GY55|F5GY55_HUMAN",1739,"Q16531","DDB1_HUMAN","DNA damage-binding protein 1",null,"DDB1"]
["22.7035","22.7926","22.9369","22.4426",{"$nulls":3},"glucose 1-phosphate metabolic process;glycogen biosynthetic process;glycogen metabolic process;UDP-glucose metabolic process;UDP-glucuronate biosynthetic process","glucose binding;identical protein binding;metal ion binding;pyrimidine ribonucleotide binding;UTP:glucose-1-phosphate uridylyltransferase activity","cytoplasm;cytosol;extracellular exosome;nucleus","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Metabolic pathways;Pentose and glucuronate interconversions;Starch and sucrose metabolism",null,null,21,21,11,"45.1","45.1","23.2","56.94",0,"215.47",2364200000,82,"0.076763","0.931167","0.0583191","0.232189","sp|Q16851|UGPA_HUMAN;tr|A0A087WYS1|A0A087WYS1_HUMAN;tr|E7EUC7|E7EUC7_HUMAN;tr|C9JQU9|C9JQU9_HUMAN;tr|C9J6Q0|C9J6Q0_HUMAN","sp|Q16851|UGPA_HUMAN;tr|A0A087WYS1|A0A087WYS1_HUMAN;tr|E7EUC7|E7EUC7_HUMAN",1760,"Q16851","UGPA_HUMAN","UTP--glucose-1-phosphate uridylyltransferase",null,"UGP2"]
["15.512","13.664","16.2671","12.7929",{"$nulls":3},"cis assembly of pre-catalytic spliceosome;mRNA splicing, via spliceosome;osteoblast differentiation","ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;identical protein binding;RNA binding","catalytic step 2 spliceosome;membrane;nucleoplasm;nucleus;spliceosomal complex;U4/U6 x U5 tri-snRNP complex;U5 snRNP","Spliceosome",null,null,5,5,5,"3.3","3.3","3.3","244.5",0,"15.937",43837000,6,"0.00914774","0.983864","0.0580091","0.0294831","sp|O75643|U520_HUMAN","sp|O75643|U520_HUMAN",357,"O75643","U520_HUMAN","U5 small nuclear ribonucleoprotein 200 kDa helicase",null,"SNRNP200"]
["19.3325","19.253","19.5924","18.8774",{"$nulls":3},"cellular response to glucose stimulus;cellular response to tumor necrosis factor;gluconeogenesis;NADH oxidation;oxaloacetate metabolic process;positive regulation of insulin secretion;pyruvate metabolic process;response to dexamethasone;response to lipopolysaccharide","GTP binding;metal ion binding;phosphoenolpyruvate carboxykinase (GTP) activity;phosphoenolpyruvate carboxykinase activity","extracellular exosome;mitochondrial matrix;mitochondrion","Adipocytokine signaling pathway;AMPK signaling pathway;Citrate cycle (TCA cycle);FoxO signaling pathway;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;Insulin resistance;Insulin signaling pathway;Metabolic pathways;PI3K-Akt signaling pathway;PPAR signaling pathway;Proximal tubule bicarbonate reclamation;Pyruvate metabolism",null,null,7,7,7,"15.9","15.9","15.9","70.729",0,"12.392",180020000,18,"0.0521109","0.948723","0.0578871","0.160938","sp|Q16822|PCKGM_HUMAN;tr|A0A0A0MS74|A0A0A0MS74_HUMAN;tr|H0YM31|H0YM31_HUMAN;tr|H0YML5|H0YML5_HUMAN;tr|B4DW73|B4DW73_HUMAN;tr|H0YNG4|H0YNG4_HUMAN;tr|H0YMA5|H0YMA5_HUMAN;tr|H0YMU6|H0YMU6_HUMAN;sp|P35558|PCKGC_HUMAN","sp|Q16822|PCKGM_HUMAN;tr|A0A0A0MS74|A0A0A0MS74_HUMAN;tr|H0YM31|H0YM31_HUMAN;tr|H0YML5|H0YML5_HUMAN;tr|B4DW73|B4DW73_HUMAN",1757,"Q16822","PCKGM_HUMAN","Phosphoenolpyruvate carboxykinase [GTP], mitochondrial","EPCK-M","PCK2"]
["19.3724","19.2878","19.5528","18.9918",{"$nulls":3},"cell redox homeostasis;cyclooxygenase pathway;neutrophil degranulation;positive regulation of transcription, DNA-templated","DNA binding;electron transfer activity;glutathione binding;heme binding;lyase activity;prostaglandin-E synthase activity;protein disulfide oxidoreductase activity","azurophil granule lumen;cytosol;extracellular region;Golgi membrane;integral component of membrane;mitochondrion;nucleus;perinuclear region of cytoplasm","Arachidonic acid metabolism;Metabolic pathways",null,null,6,6,6,"21.2","21.2","21.2","41.943",0,"11.682",137560000,18,"0.0668479","0.935157","0.0578213","0.203839","sp|Q9H7Z7|PGES2_HUMAN;tr|X6RJ95|X6RJ95_HUMAN;tr|A6NHH0|A6NHH0_HUMAN","sp|Q9H7Z7|PGES2_HUMAN;tr|X6RJ95|X6RJ95_HUMAN",2612,"Q9H7Z7","PGES2_HUMAN","Prostaglandin E synthase 2",null,"PTGES2"]
["18.9527","19.1583","19.8377","18.1589",{"$nulls":3},"protein import into mitochondrial matrix;protein targeting to mitochondrion","ATP binding;chaperone binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},4,4,4,"10.6","10.6","10.6","51.355",0,"10.977",112130000,9,"0.0212437","0.974987","0.0571585","0.0675892","sp|O43615|TIM44_HUMAN;tr|M0QXU7|M0QXU7_HUMAN;tr|M0QXM9|M0QXM9_HUMAN","sp|O43615|TIM44_HUMAN;tr|M0QXU7|M0QXU7_HUMAN;tr|M0QXM9|M0QXM9_HUMAN",252,"O43615","TIM44_HUMAN","Mitochondrial import inner membrane translocase subunit TIM44",null,"TIMM44"]
["18.6919","18.7534","19.1583","18.1755",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;actin filament network formation;intestinal D-glucose absorption;positive regulation of multicellular organism growth;positive regulation of protein localization to plasma membrane;regulation of microvillus length;terminal web assembly","actin filament binding;calcium ion binding;structural constituent of cytoskeleton","actin filament;actin filament bundle;brush border;cytoplasm;extracellular exosome;terminal web",{"$nulls":3},8,7,7,20,"17.8","17.8","70.253",0,"18.728",146890000,22,"0.0361372","0.957809","0.0557728","0.113274","sp|Q14651|PLSI_HUMAN;tr|C9JAM8|C9JAM8_HUMAN;tr|C9J359|C9J359_HUMAN;tr|C9J0F3|C9J0F3_HUMAN;tr|C9JAM3|C9JAM3_HUMAN;tr|C9JVY2|C9JVY2_HUMAN;tr|C9JU08|C9JU08_HUMAN","sp|Q14651|PLSI_HUMAN",1632,"Q14651","PLSI_HUMAN","Plastin-1",null,"PLS1"]
["19.0476","19.4251","19.6489","18.7126",{"$nulls":4},"metal ion binding;protein serine/threonine phosphatase activity","cytosol;plasma membrane",{"$nulls":3},1,1,1,"6.4","6.4","6.4","20.644",0,"6.1556",56389000,8,"0.0350876","0.96031","0.0555687","0.110096","tr|E9PKB5|E9PKB5_HUMAN;tr|B8ZZF0|B8ZZF0_HUMAN;tr|C9JIR6|C9JIR6_HUMAN;sp|P35813|PPM1A_HUMAN;sp|O75688|PPM1B_HUMAN","tr|E9PKB5|E9PKB5_HUMAN;tr|B8ZZF0|B8ZZF0_HUMAN;tr|C9JIR6|C9JIR6_HUMAN;sp|P35813|PPM1A_HUMAN;sp|O75688|PPM1B_HUMAN",360,"E9PKB5","E9PKB5_HUMAN",null,null,"PPM1A"]
["22.2352","22.098","22.4264","21.7977",{"$nulls":3},"behavioral fear response;cellular response to dexamethasone stimulus;G1/S transition of mitotic cell cycle;lung development;mRNA export from nucleus;negative regulation of neuron differentiation;negative regulation of translation;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of mitotic cell cycle;regulation of translation;RNA export from nucleus;stem cell population maintenance;translational initiation;viral process","enzyme binding;eukaryotic initiation factor 4G binding;repressing transcription factor binding;RNA 7-methylguanosine cap binding;RNA binding;RNA cap binding;translation initiation factor activity","chromatoid body;cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;eukaryotic translation initiation factor 4F complex;extracellular exosome;mRNA cap binding complex;P-body;perinuclear region of cytoplasm;RISC complex","EGFR tyrosine kinase inhibitor resistance;HIF-1 signaling pathway;Insulin signaling pathway;Longevity regulating pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;RNA transport",null,null,3,3,3,"22.6","22.6","22.6","25.097",0,"28.398",441250000,22,"0.0549675","0.946548","0.0544834","0.16933","sp|P06730|IF4E_HUMAN;tr|D6RFJ3|D6RFJ3_HUMAN;tr|D6RBW1|D6RBW1_HUMAN;tr|H0Y8J7|H0Y8J7_HUMAN","sp|P06730|IF4E_HUMAN;tr|D6RFJ3|D6RFJ3_HUMAN;tr|D6RBW1|D6RBW1_HUMAN",531,"P06730","IF4E_HUMAN","Eukaryotic translation initiation factor 4E","IF4E;IF-4E","EIF4E"]
["19.969","19.7121","19.7988","19.7747",{"$nulls":4},"oxidoreductase activity",{"$nulls":4},3,3,3,"8.1","8.1","8.1","44.648",0,"6.0464",151900000,13,"0.144341","0.879654","0.053793","0.416912","tr|J3QRD1|J3QRD1_HUMAN;sp|P51648|AL3A2_HUMAN;tr|I3L1M4|I3L1M4_HUMAN;tr|J3KTD9|J3KTD9_HUMAN;tr|I3L2W1|I3L2W1_HUMAN;tr|J3QS00|J3QS00_HUMAN","tr|J3QRD1|J3QRD1_HUMAN;sp|P51648|AL3A2_HUMAN;tr|I3L1M4|I3L1M4_HUMAN",1142,"J3QRD1","J3QRD1_HUMAN",null,null,"ALDH3A2"]
["19.0794","18.9072","19.019","18.8612",{"$nulls":9},1,1,1,"51.9","51.9","51.9","6.268","0.0017489","2.2457",10570000,2,"0.159114","0.866603","0.0532255","0.455794","tr|E5RHZ4|E5RHZ4_HUMAN;tr|H0YBJ0|H0YBJ0_HUMAN;sp|P06746|DPOLB_HUMAN","tr|E5RHZ4|E5RHZ4_HUMAN;tr|H0YBJ0|H0YBJ0_HUMAN;sp|P06746|DPOLB_HUMAN",535,"E5RHZ4","E5RHZ4_HUMAN",null,null,"POLB"]
["19.7328","19.5357","19.9491","19.2134",{"$nulls":3},"branched-chain amino acid catabolic process;fatty acid metabolic process","acyl-CoA dehydrogenase activity;flavin adenine dinucleotide binding","extracellular exosome;mitochondrial matrix;mitochondrion","Fatty acid degradation;Fatty acid metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,4,4,4,"13.7","13.7","13.7","47.485",0,"9.3617",147530000,17,"0.0447978","0.95581","0.0530396","0.139276","sp|P45954|ACDSB_HUMAN","sp|P45954|ACDSB_HUMAN",1017,"P45954","ACDSB_HUMAN","Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial","BCAD","ACADSB"]
["17.0271","16.8747","16.7703","17.03",{"$nulls":3},"centrosome localization;G1/S transition of mitotic cell cycle;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;NLS-bearing protein import into nucleus;positive regulation of glucokinase activity;positive regulation of GTPase activity;positive regulation of mitotic centrosome separation;protein folding;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of gluconeogenesis involved in cellular glucose homeostasis;regulation of glycolytic process;response to amphetamine;RNA export from nucleus;sister chromatid cohesion;spindle organization;tRNA export from nucleus;ubiquitin-dependent protein catabolic process;viral process;viral transcription","ligase activity;metal ion binding;peptidyl-prolyl cis-trans isomerase activity;protein complex binding;Ran GTPase binding;RNA binding;SUMO transferase activity","annulate lamellae;centrosome;cytoplasm;cytoplasmic periphery of the nuclear pore complex;cytosol;host cell;intracellular membrane-bounded organelle;membrane;mitochondrion;nuclear envelope;nuclear inclusion body;nuclear membrane;nuclear pore;nuclear pore cytoplasmic filaments;nuclear pore nuclear basket","RNA transport",null,null,9,9,9,"4.4","4.4","4.4","358.2",0,"54.175",227900000,36,"0.114543","0.903679","0.0507507","0.337041","sp|P49792|RBP2_HUMAN;tr|F8WBP7|F8WBP7_HUMAN;tr|F8W705|F8W705_HUMAN;tr|J3KQ37|J3KQ37_HUMAN;sp|Q7Z3J3|RGPD4_HUMAN;sp|A6NKT7|RGPD3_HUMAN;tr|J3KNE0|J3KNE0_HUMAN;sp|Q99666|RGPD5_HUMAN;sp|O14715|RGPD8_HUMAN","sp|P49792|RBP2_HUMAN",1097,"P49792","RBP2_HUMAN","E3 SUMO-protein ligase RanBP2",null,"RANBP2"]
["22.6497","22.2188","22.8657","21.9034",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;intracellular membrane-bounded organelle;nucleoplasm;nucleus;P-body;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex","Proteasome",null,null,7,7,7,31,31,31,"29.483",0,"113.94",805460000,42,"0.0299091","0.966628","0.0497255","0.0943254","sp|P25789|PSA4_HUMAN;tr|H0YMZ1|H0YMZ1_HUMAN;tr|H0YN18|H0YN18_HUMAN;tr|H0YL69|H0YL69_HUMAN;tr|H0YMA1|H0YMA1_HUMAN;tr|H0YKT8|H0YKT8_HUMAN;tr|H0YMI6|H0YMI6_HUMAN;tr|H0YKS0|H0YKS0_HUMAN;tr|H0YLC2|H0YLC2_HUMAN;tr|H0YLS6|H0YLS6_HUMAN;tr|H0YMV3|H0YMV3_HUMAN","sp|P25789|PSA4_HUMAN;tr|H0YMZ1|H0YMZ1_HUMAN;tr|H0YN18|H0YN18_HUMAN;tr|H0YL69|H0YL69_HUMAN;tr|H0YMA1|H0YMA1_HUMAN;tr|H0YKT8|H0YKT8_HUMAN;tr|H0YMI6|H0YMI6_HUMAN",804,"P25789","PSA4_HUMAN","Proteasome subunit alpha type-4",null,"PSMA4"]
["21.3176","21.2444","21.5096","20.9535",{"$nulls":3},"axon guidance;microtubule-based process;mitotic cell cycle","GTP binding;GTPase activity;peptide binding;structural constituent of cytoskeleton","axon;cell periphery;cytoplasm;dendrite;extracellular exosome;microtubule;microtubule cytoskeleton;neuronal cell body;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,17,3,3,"44.7","14.2","14.2","50.432",0,"19.129",533100000,28,"0.0572815","0.944401","0.049387","0.1761","sp|Q13509|TBB3_HUMAN;tr|A0A0B4J269|A0A0B4J269_HUMAN;tr|G3V2A3|G3V2A3_HUMAN;tr|G3V5W4|G3V5W4_HUMAN;tr|G3V2R8|G3V2R8_HUMAN;tr|G3V3R4|G3V3R4_HUMAN;tr|G3V2N6|G3V2N6_HUMAN;tr|G3V3J6|G3V3J6_HUMAN;tr|G3V3W7|G3V3W7_HUMAN","sp|Q13509|TBB3_HUMAN;tr|A0A0B4J269|A0A0B4J269_HUMAN",1565,"Q13509","TBB3_HUMAN","Tubulin beta-3 chain",null,"TUBB3"]
["17.8025","17.2634","17.8122","17.1573",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;histone mRNA metabolic process;mRNA 3'-end processing;mRNA cis splicing, via spliceosome;mRNA export from nucleus;mRNA splicing, via spliceosome;nuclear export;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of cell growth;positive regulation of mRNA 3'-end processing;positive regulation of mRNA splicing, via spliceosome;positive regulation of RNA binding;pre-mRNA cleavage required for polyadenylation;primary miRNA processing;regulation of translational initiation;RNA export from nucleus;RNA metabolic process;RNA splicing;snRNA transcription from RNA polymerase II promoter;spliceosomal complex assembly;termination of RNA polymerase II transcription;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","mRNA binding;RNA 7-methylguanosine cap binding;RNA binding;RNA cap binding","cytosol;intracellular ribonucleoprotein complex;mitochondrion;mRNA cap binding complex;nuclear cap binding complex;nucleoplasm;nucleus;RNA cap binding complex","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,3,3,3,"7.1","7.1","7.1","91.838",0,"10.77",66951000,16,"0.0362594","0.957597","0.0481977","0.113644","sp|Q09161|NCBP1_HUMAN","sp|Q09161|NCBP1_HUMAN",1482,"Q09161","NCBP1_HUMAN","Nuclear cap-binding protein subunit 1",null,"NCBP1"]
["22.4229","22.0314","22.5426","21.8159",{"$nulls":3},"fumarate metabolic process;homeostasis of number of cells within a tissue;malate metabolic process;tricarboxylic acid cycle","fumarate hydratase activity","cytoplasm;extracellular exosome;mitochondrial matrix;mitochondrion;tricarboxylic acid cycle enzyme complex","Carbon metabolism;Citrate cycle (TCA cycle);Cushing syndrome;Metabolic pathways;Pathways in cancer;Pyruvate metabolism;Renal cell carcinoma",null,null,12,12,12,"34.7","34.7","34.7","54.636",0,"183.74",1263100000,76,"0.0370816","0.957007","0.0479259","0.116129","sp|P07954|FUMH_HUMAN","sp|P07954|FUMH_HUMAN",553,"P07954","FUMH_HUMAN","Fumarate hydratase, mitochondrial","umarase","FH"]
["15.9396","15.8724","16.752","14.9661",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;cellular response to glucagon stimulus;high-density lipoprotein particle assembly;male gonad development;renal water homeostasis;spermatogenesis;stimulatory C-type lectin receptor signaling pathway","ATP binding;cAMP-dependent protein kinase activity;protein serine/threonine kinase activity","ciliary base;cytosol;intercellular bridge;nucleoplasm","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Amoebiasis;Amphetamine addiction;Apelin signaling pathway;Autophagy - animal;Bile secretion;Calcium signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cortisol synthesis and secretion;Cushing syndrome;Dilated cardiomyopathy (DCM);Dopaminergic synapse;Endocrine and other factor-regulated calcium reabsorption;Endocrine resistance;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Hedgehog signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Inflammatory mediator regulation of TRP channels;Insulin secretion;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Morphine addiction;Olfactory transduction;Oocyte meiosis;Ovarian steroidogenesis;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Platelet activation;Prion diseases;Progesterone-mediated oocyte maturation;Proteoglycans in cancer;Ras signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Taste transduction;Thermogenesis;Thyroid hormone signaling pathway;Thyroid hormone synthesis;Tight junction;Vascular smooth muscle contraction;Vasopressin-regulated water reabsorption;Vibrio cholerae infection;Viral carcinogenesis;Wnt signaling pathway",null,null,1,1,1,"6.8","6.8","6.8","40.434","0.0053673","1.8993",12498000,2,"0.0164348","0.977787","0.0469608","0.0525537","sp|P22612|KAPCG_HUMAN","sp|P22612|KAPCG_HUMAN",767,"P22612","KAPCG_HUMAN","cAMP-dependent protein kinase catalytic subunit gamma","KA C-gamma","PRKACG"]
["23.4853","23.4704","23.6918","23.1721",{"$nulls":3},"cell redox homeostasis;cellular protein metabolic process;cellular response to hypoxia;cellular response to oxidative stress;chylomicron assembly;interleukin-12-mediated signaling pathway;peptidyl-proline hydroxylation to 4-hydroxy-L-proline;positive regulation of viral entry into host cell;post-translational protein modification;protein folding;regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;response to endoplasmic reticulum stress;very-low-density lipoprotein particle assembly","enzyme binding;integrin binding;peptide disulfide oxidoreductase activity;procollagen-proline 4-dioxygenase activity;protein disulfide isomerase activity;protein heterodimerization activity;RNA binding","endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment;external side of plasma membrane;extracellular exosome;extracellular matrix;extracellular region;focal adhesion;melanosome;procollagen-proline 4-dioxygenase complex","Protein processing in endoplasmic reticulum",null,null,17,17,17,"43.1","43.1","43.1","57.116",0,"323.31",4919100000,96,"0.0574449","0.945645","0.0459061","0.176577","sp|P07237|PDIA1_HUMAN;tr|H7BZ94|H7BZ94_HUMAN;tr|H0Y3Z3|H0Y3Z3_HUMAN;tr|I3L312|I3L312_HUMAN;tr|I3L398|I3L398_HUMAN;tr|I3L0S0|I3L0S0_HUMAN;tr|I3NI03|I3NI03_HUMAN;tr|I3L3U6|I3L3U6_HUMAN;tr|I3L4M2|I3L4M2_HUMAN;tr|I3L3P5|I3L3P5_HUMAN;tr|I3L514|I3L514_HUMAN;tr|I3L1Y5|I3L1Y5_HUMAN","sp|P07237|PDIA1_HUMAN;tr|H7BZ94|H7BZ94_HUMAN",540,"P07237","PDIA1_HUMAN","Protein disulfide-isomerase","DI","P4HB"]
["17.5096","19.8324","17.5139","19.7375",{"$nulls":3},"arginine catabolic process;citrulline metabolic process;positive regulation of nitric oxide biosynthetic process","dimethylargininase activity",{"$nulls":4},4,4,4,"27.6","27.6","27.6","20.535",0,"66.548",56242000,16,"0.0087447","0.984172","0.0453339","0.0281966","tr|B4DYP1|B4DYP1_HUMAN;sp|O94760|DDAH1_HUMAN","tr|B4DYP1|B4DYP1_HUMAN;sp|O94760|DDAH1_HUMAN",390,"B4DYP1","B4DYP1_HUMAN",null,null,"DDAH1"]
["19.8265","20.0994","19.7143","20.1216",{"$nulls":3},"protein targeting to mitochondrion",null,"integral component of membrane;mitochondrial outer membrane",{"$nulls":3},7,7,7,"16.1","16.1","16.1","51.462",0,"16.469",227860000,18,"0.0598391","0.944581","0.0449972","0.183556","tr|A0A0A0MRK6|A0A0A0MRK6_HUMAN;sp|Q13505|MTX1_HUMAN;tr|A0A0C4DFQ1|A0A0C4DFQ1_HUMAN","tr|A0A0A0MRK6|A0A0A0MRK6_HUMAN;sp|Q13505|MTX1_HUMAN;tr|A0A0C4DFQ1|A0A0C4DFQ1_HUMAN",1564,"A0A0A0MRK6","A0A0A0MRK6_HUMAN"]
["18.8841","18.4262","19.1952","18.0257",{"$nulls":4},"structural constituent of ribosome",{"$nulls":4},1,1,1,"6.7","6.7","6.7","23.146","0.0011058","2.7045",37947000,9,"0.0223914","0.972275","0.0446835","0.0711563","tr|A2IDC7|A2IDC7_HUMAN;tr|Q4TT37|Q4TT37_HUMAN;tr|A2IDC6|A2IDC6_HUMAN;sp|Q13084|RM28_HUMAN","tr|A2IDC7|A2IDC7_HUMAN;tr|Q4TT37|Q4TT37_HUMAN;tr|A2IDC6|A2IDC6_HUMAN;sp|Q13084|RM28_HUMAN",1517,"A2IDC7","A2IDC7_HUMAN",null,null,"MRPL28"]
["20.9799","21.3096","21.2685","20.9337",{"$nulls":3},"ATP synthesis coupled electron transport;lactation;mitochondrial electron transport, cytochrome c to oxygen;response to cold","copper ion binding;cytochrome-c oxidase activity","extracellular exosome;integral component of membrane;membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex IV;mitochondrion;respiratory chain complex IV","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,3,3,3,"20.3","20.3","20.3","25.565",0,"9.0564",164650000,16,"0.0605681","0.944769","0.0436287","0.185675","sp|P00403|COX2_HUMAN","sp|P00403|COX2_HUMAN",467,"P00403","COX2_HUMAN","Cytochrome c oxidase subunit 2",null,"MT-CO2"]
["20.2663","20.5223","20.0371","20.6671",{"$nulls":3},"cell division;cell separation after cytokinesis;ESCRT III complex disassembly;establishment of protein localization;mitotic metaphase plate congression;multivesicular body assembly;nucleus organization;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;vacuolar transport;viral budding via host ESCRT complex","identical protein binding;protein domain specific binding","cytosol;endosome membrane;ESCRT III complex;extracellular exosome;late endosome membrane;membrane coat;midbody;nucleus","Endocytosis;Necroptosis",null,null,1,1,1,"4.5","4.5","4.5","22.109","0.00538","1.9128",87040000,5,"0.039701","0.956139","0.0421686","0.124021","sp|Q7LBR1|CHM1B_HUMAN","sp|Q7LBR1|CHM1B_HUMAN",1940,"Q7LBR1","CHM1B_HUMAN","Charged multivesicular body protein 1b",null,"CHMP1B"]
["18.5531","18.7267","19.0298","18.1666",{"$nulls":3},"arginine catabolic process;L-phenylalanine catabolic process;tyrosine catabolic process","fumarylacetoacetase activity;metal ion binding","cytosol;extracellular exosome","Metabolic pathways;Tyrosine metabolism",null,null,3,3,3,"8.8","8.8","8.8","46.374",0,"7.1532",79199000,9,"0.0300239","0.966812","0.0416813","0.0946767","sp|P16930|FAAA_HUMAN;tr|H3BNP8|H3BNP8_HUMAN;tr|H0YLC7|H0YLC7_HUMAN","sp|P16930|FAAA_HUMAN",700,"P16930","FAAA_HUMAN","Fumarylacetoacetase","AA","FAH"]
["21.0778","20.7371","21.3877","20.3454",{"$nulls":3},"lysosome organization;mitochondrial fragmentation involved in apoptotic process;mitochondrion to lysosome transport;negative regulation of cell death;negative regulation of cellular protein localization;negative regulation of gene expression;negative regulation of inflammatory response;negative regulation of late endosome to lysosome transport;negative regulation of lysosomal protein catabolic process;negative regulation of neuron death;negative regulation of protein homooligomerization;neurotransmitter receptor transport, endosome to plasma membrane;positive regulation of canonical Wnt signaling pathway;positive regulation of cellular protein catabolic process;positive regulation of dopamine biosynthetic process;positive regulation of dopamine receptor signaling pathway;positive regulation of gene expression;positive regulation of locomotion involved in locomotory behavior;positive regulation of mitochondrial fission;positive regulation of Wnt protein secretion;protein destabilization;protein localization to organelle;regulation of cellular protein metabolic process;regulation of dendritic spine maintenance;regulation of macroautophagy;regulation of mitochondrion organization;regulation of presynapse assembly;regulation of protein stability;regulation of terminal button organization;retrograde transport, endosome to Golgi;retrograde transport, endosome to plasma membrane;transcytosis;voluntary musculoskeletal movement;Wnt signaling pathway","D1 dopamine receptor binding;protein transporter activity","cytosol;early endosome;endosome;endosome membrane;extracellular exosome;late endosome;lysosomal membrane;lysosome;mitochondrion-derived vesicle;neuron projection;neuronal cell body;perinuclear region of cytoplasm;postsynaptic density;retromer complex;retromer, cargo-selective complex;tubular endosome","Endocytosis",null,null,11,11,11,"18.2","18.2","18.2","91.706",0,"51.725",758680000,43,"0.0235025","0.970851","0.0409031","0.0746019","sp|Q96QK1|VPS35_HUMAN;tr|I3L4S0|I3L4S0_HUMAN;tr|I3L4P4|I3L4P4_HUMAN","sp|Q96QK1|VPS35_HUMAN",2339,"Q96QK1","VPS35_HUMAN","Vacuolar protein sorting-associated protein 35","VPS35","VPS35"]
["13.459","14.0168","14.5322","12.8619",{"$nulls":3},"regulation of apoptotic process","ADP binding",{"$nulls":4},1,1,1,"0.9","0.9","0.9","132.46","0.0004008","3.3871",10704000,2,"0.0144967","0.979717","0.0409002","0.0464523","tr|C9JLV4|C9JLV4_HUMAN;sp|O14727|APAF_HUMAN","tr|C9JLV4|C9JLV4_HUMAN;sp|O14727|APAF_HUMAN",167,"C9JLV4","C9JLV4_HUMAN",null,null,"APAF1"]
["20.2305","20.4045","20.2644","20.29",{"$nulls":3},"cell division;hair follicle maturation;meiotic cell cycle checkpoint;spermatid development;tRNA methylation;tRNA modification","RNA binding;tRNA (cytosine-5-)-methyltransferase activity;tRNA binding","chromatoid body;cytoplasm;nucleolus;nucleoplasm;spindle",{"$nulls":3},10,10,10,"24.6","24.6","24.6","86.47",0,"137.11",539190000,53,"0.159952","0.866704","0.0402746","0.457988","sp|Q08J23|NSUN2_HUMAN","sp|Q08J23|NSUN2_HUMAN",1480,"Q08J23","NSUN2_HUMAN","tRNA (cytosine(34)-C(5))-methyltransferase",null,"NSUN2"]
["24.3643","24.3016","24.4788","24.1083",{"$nulls":3},"MAPK cascade","ATP binding;enzyme binding;phosphatidylethanolamine binding;protein kinase binding;RNA binding;serine-type endopeptidase inhibitor activity","cytosol;extracellular exosome;nucleus",{"$nulls":3},10,10,10,"73.8","73.8","73.8","21.057",0,"43.091",1725900000,68,"0.0689469","0.93611","0.0394306","0.209874","sp|P30086|PEBP1_HUMAN","sp|P30086|PEBP1_HUMAN",864,"P30086","PEBP1_HUMAN","Phosphatidylethanolamine-binding protein 1","EBP-1","PEBP1"]
["21.012","20.891","21.183","20.6437",{"$nulls":3},"ubiquitin-dependent protein catabolic process","ubiquitin protein ligase binding","cullin-RING ubiquitin ligase complex;cytosol;nucleoplasm",{"$nulls":3},14,14,14,"21.3","21.3","21.3","102.75",0,"257.46",1231400000,51,"0.0443843","0.95581","0.0381498","0.138043","tr|K4DI93|K4DI93_HUMAN;sp|Q13620|CUL4B_HUMAN;tr|A6NE76|A6NE76_HUMAN","tr|K4DI93|K4DI93_HUMAN;sp|Q13620|CUL4B_HUMAN",1580,"K4DI93","K4DI93_HUMAN"]
["18.1066","18.2214","18.6821","17.5703",{"$nulls":9},2,2,2,"21.5","21.5","21.5","25.766","0.00076017","2.9033",26972000,7,"0.0212502","0.975334","0.0377846","0.0676095","tr|F8WDP1|F8WDP1_HUMAN;tr|A0A0A0MRY0|A0A0A0MRY0_HUMAN;sp|Q8WUA7|TB22A_HUMAN","tr|F8WDP1|F8WDP1_HUMAN;tr|A0A0A0MRY0|A0A0A0MRY0_HUMAN;sp|Q8WUA7|TB22A_HUMAN",2136,"F8WDP1","F8WDP1_HUMAN",null,null,"TBC1D22A"]
["15.8766","15.8382","15.6302","16.0103",{"$nulls":3},"activation of NF-kappaB-inducing kinase activity;B-1 B cell differentiation;defense response;Fc-epsilon receptor signaling pathway;innate immune response;negative regulation of apoptotic process;nuclear export;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interleukin-2 production;positive regulation of NF-kappaB transcription factor activity;positive regulation of protein ubiquitination;positive regulation of T cell activation;positive regulation of T cell cytokine production;protein oligomerization;proteolysis;regulation of apoptotic process;regulation of T cell receptor signaling pathway;response to fungus;response to molecule of bacterial origin;stimulatory C-type lectin receptor signaling pathway;T cell proliferation;T cell receptor signaling pathway","cysteine-type endopeptidase activity;identical protein binding;peptidase activity;protease binding;protein self-association;signal transducer activity;ubiquitin-protein transferase activity","CBM complex;cytoplasm;cytosol;fibrillar center;nucleolus;nucleus;perinuclear region of cytoplasm;plasma membrane;protein complex","B cell receptor signaling pathway;C-type lectin receptor signaling pathway;NF-kappa B signaling pathway;T cell receptor signaling pathway;Tuberculosis",null,null,2,2,2,"3.4","3.4","3.4","92.271",0,"6.6129",19982000,2,"0.0636194","0.937443","0.0371556","0.194522","sp|Q9UDY8|MALT1_HUMAN","sp|Q9UDY8|MALT1_HUMAN",2818,"Q9UDY8","MALT1_HUMAN","Mucosa-associated lymphoid tissue lymphoma translocation protein 1",null,"MALT1"]
["21.5345","21.2094","21.6043","21.0671",{"$nulls":3},"apoptotic process;brain development;cellular protein metabolic process;cellular response to hydrogen peroxide;circadian sleep/wake cycle, REM sleep;defense response;embryo implantation;eye development;negative regulation of blood vessel remodeling;negative regulation of cell death;negative regulation of collagen catabolic process;negative regulation of cysteine-type endopeptidase activity;negative regulation of elastin catabolic process;negative regulation of extracellular matrix disassembly;negative regulation of peptidase activity;negative regulation of proteolysis;neutrophil degranulation;positive regulation of cell proliferation;positive regulation of DNA replication;post-translational protein modification;regulation of programmed cell death;regulation of tissue remodeling;response to axon injury;response to carbohydrate;response to drug;response to estradiol;response to hypoxia;response to nutrient levels;response to toxic substance;salivary gland development;Sertoli cell development;supramolecular fiber organization","amyloid-beta binding;cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;identical protein binding;protease binding","axon;basement membrane;contractile fiber;endoplasmic reticulum lumen;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;lysosome;multivesicular body;neuronal cell body;nuclear membrane;perinuclear region of cytoplasm;tertiary granule lumen","Salivary secretion",null,null,2,2,2,"19.2","19.2","19.2","15.799","0.0010897","2.5307",157150000,4,"0.0369219","0.95722","0.0363064","0.115646","sp|P01034|CYTC_HUMAN","sp|P01034|CYTC_HUMAN",477,"P01034","CYTC_HUMAN","Cystatin-C",null,"CST3"]
["22.8639","22.9147","23.34","22.3675",{"$nulls":3},"in utero embryonic development;male germ cell proliferation;male gonad development;translational initiation;transmembrane transport","metal ion binding;RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2 complex","RNA transport",null,null,15,15,15,"43.8","43.8","43.8","38.388",0,"96.437",1512800000,86,"0.0229724","0.971553","0.0355244","0.0729588","sp|P20042|IF2B_HUMAN","sp|P20042|IF2B_HUMAN",737,"P20042","IF2B_HUMAN","Eukaryotic translation initiation factor 2 subunit 2",null,"EIF2S2"]
["16.4338","16.8277","17.1618","16.0304",{"$nulls":3},"cotranslational protein targeting to membrane;translation","structural constituent of ribosome","integral component of membrane;ribosome;Sec61 translocon complex",{"$nulls":3},3,1,1,"21.5","11.8","11.8","27.168",0,"3.6097",11236000,3,"0.0181378","0.975754","0.0346804","0.057895","tr|H3BN98|H3BN98_HUMAN;tr|H3BTX6|H3BTX6_HUMAN;tr|H3BS91|H3BS91_HUMAN;tr|H3BPJ2|H3BPJ2_HUMAN;sp|Q15041|AR6P1_HUMAN","tr|H3BN98|H3BN98_HUMAN",3103,"H3BN98","H3BN98_HUMAN"]
["18.2649","17.8747","18.2562","17.8147",{"$nulls":3},"cytoskeleton organization","actin binding",{"$nulls":4},4,4,4,"16.7","16.7","16.7","46.07",0,"11.74",84216000,21,"0.0372726","0.956992","0.0343866","0.116706","tr|J3QSX6|J3QSX6_HUMAN;tr|F8W8M4|F8W8M4_HUMAN;tr|A0A0A0MRL6|A0A0A0MRL6_HUMAN;sp|O14639|ABLM1_HUMAN;tr|H0Y7N6|H0Y7N6_HUMAN;tr|F6XFR5|F6XFR5_HUMAN","tr|J3QSX6|J3QSX6_HUMAN;tr|F8W8M4|F8W8M4_HUMAN;tr|A0A0A0MRL6|A0A0A0MRL6_HUMAN;sp|O14639|ABLM1_HUMAN;tr|H0Y7N6|H0Y7N6_HUMAN;tr|F6XFR5|F6XFR5_HUMAN",165,"J3QSX6","J3QSX6_HUMAN",null,null,"ABLIM1"]
["24.096","24.1381","24.5755","23.594",{"$nulls":3},"DNA repair","class I DNA-(apurinic or apyrimidinic site) lyase activity;class III/IV DNA-(apurinic or apyrimidinic site) lyase activity;DNA binding;endonuclease activity;metal ion binding","centrosome;mitochondrion;nucleus",{"$nulls":3},8,8,8,"37.6","37.6","37.6","29.19",0,"189.75",1876300000,69,"0.0206824","0.97496","0.032341","0.0658419","tr|G3V3M6|G3V3M6_HUMAN;sp|P27695|APEX1_HUMAN;tr|G3V5Q1|G3V5Q1_HUMAN;tr|G3V3C7|G3V3C7_HUMAN;tr|A0A0C4DGK8|A0A0C4DGK8_HUMAN;tr|G3V5D9|G3V5D9_HUMAN;tr|G3V5M0|G3V5M0_HUMAN;tr|G3V359|G3V359_HUMAN;tr|G3V3Y6|G3V3Y6_HUMAN;tr|H7C4A8|H7C4A8_HUMAN","tr|G3V3M6|G3V3M6_HUMAN;sp|P27695|APEX1_HUMAN;tr|G3V5Q1|G3V5Q1_HUMAN;tr|G3V3C7|G3V3C7_HUMAN;tr|A0A0C4DGK8|A0A0C4DGK8_HUMAN;tr|G3V5D9|G3V5D9_HUMAN",825,"G3V3M6","G3V3M6_HUMAN","DNA-(apurinic or apyrimidinic site) lyase {ECO:0000256|RuleBase:RU362131}",null,"APEX1"]
["15.5873","16.669","16.2249","15.967",{"$nulls":3},"collagen fibril organization;peptidyl-proline hydroxylation to 4-hydroxy-L-proline","identical protein binding;iron ion binding;L-ascorbic acid binding;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;procollagen-proline 4-dioxygenase activity","endoplasmic reticulum;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;membrane;mitochondrion;procollagen-proline 4-dioxygenase complex","Arginine and proline metabolism;Metabolic pathways",null,null,3,3,3,"7.9","7.9","7.9","61.049","0.00039635","3.3039",27025000,5,"0.0181443","0.976099","0.0321999","0.0579153","sp|P13674|P4HA1_HUMAN","sp|P13674|P4HA1_HUMAN",660,"P13674","P4HA1_HUMAN","Prolyl 4-hydroxylase subunit alpha-1",{"$f":"-PH alpha-1","v":{"$error":"#NAME?"}},"P4HA1"]
["21.1753","21.1296","21.3456","20.8951",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;regulation of transcription, DNA-templated;regulation of translation;RNA export from nucleus;termination of RNA polymerase II transcription","DNA binding;RNA binding","cytoplasmic ribonucleoprotein granule;nuclear speck;nucleoplasm;nucleus;transcription export complex",{"$nulls":3},2,2,2,"13.8","13.8","13.8","23.671",0,"6.564",224280000,12,"0.0456479","0.955761","0.0321045","0.141808","sp|P82979|SARNP_HUMAN;tr|H0YHG0|H0YHG0_HUMAN;tr|F8VZQ9|F8VZQ9_HUMAN","sp|P82979|SARNP_HUMAN;tr|H0YHG0|H0YHG0_HUMAN;tr|F8VZQ9|F8VZQ9_HUMAN",1388,"P82979","SARNP_HUMAN","SAP domain-containing ribonucleoprotein",null,"SARNP"]
["19.3937","19.5313","18.3148","20.5499",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","small ribosomal subunit rRNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;small ribosomal subunit","Ribosome",null,null,1,1,1,"9.6","9.6","9.6","14.226",0,"4.5447",64951000,4,"0.00834583","0.983502","0.0301437","0.0269223","sp|P82932|RT06_HUMAN","sp|P82932|RT06_HUMAN",1386,"P82932","RT06_HUMAN","28S ribosomal protein S6, mitochondrial","6mt;RP-S6","MRPS6"]
["21.2382","21.3726","21.1447","21.407",{"$nulls":3},"2-oxoglutarate metabolic process;carbohydrate metabolic process;glyoxylate cycle;isocitrate metabolic process;mitochondrion organization;NADP biosynthetic process;negative regulation of glial cell migration;negative regulation of glial cell proliferation;negative regulation of matrix metallopeptidase secretion;tricarboxylic acid cycle","isocitrate dehydrogenase (NADP+) activity;magnesium ion binding;NAD binding","cytosol;extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;peroxisome","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Glutathione metabolism;Metabolic pathways;Peroxisome",null,null,6,6,6,"17.3","17.3","17.3","50.909",0,"64.661",535300000,38,"0.0657707","0.936875","0.0295753","0.200735","sp|P48735|IDHP_HUMAN;tr|H0YL11|H0YL11_HUMAN","sp|P48735|IDHP_HUMAN;tr|H0YL11|H0YL11_HUMAN",1061,"P48735","IDHP_HUMAN","Isocitrate dehydrogenase [NADP], mitochondrial","DH","IDH2"]
["21.689","21.4064","21.9958","21.0406",{"$nulls":3},"alcohol metabolic process;carbohydrate metabolic process;ethanol catabolic process;ethanol oxidation","aldehyde dehydrogenase (NAD) activity;aldehyde dehydrogenase [NAD(P)+] activity;electron transfer activity;NAD binding","extracellular exosome;mitochondrial matrix","Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Fatty acid degradation;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Lysine degradation;Metabolic pathways;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,11,10,10,34,"32.3","32.3","56.381",0,"45.806",661670000,44,"0.0185707","0.975536","0.0295105","0.0592499","sp|P05091|ALDH2_HUMAN;tr|S4R3S4|S4R3S4_HUMAN;tr|F8VP50|F8VP50_HUMAN","sp|P05091|ALDH2_HUMAN",510,"P05091","ALDH2_HUMAN","Aldehyde dehydrogenase, mitochondrial",null,"ALDH2"]
["18.7321","18.5367","18.7612","18.4533",{"$nulls":3},"NADPH regeneration;oxidation-reduction process;proton transport;reactive oxygen species metabolic process;tricarboxylic acid cycle","NAD binding;NAD(P)+ transhydrogenase (AB-specific) activity;NAD(P)+ transhydrogenase (B-specific) activity;NAD(P)+ transhydrogenase activity;NADP binding","integral component of membrane;membrane;mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrion","Metabolic pathways;Nicotinate and nicotinamide metabolism",null,null,6,6,6,"7.6","7.6","7.6","113.89",0,"21.5",170620000,23,"0.0479983","0.954345","0.0271349","0.148788","sp|Q13423|NNTM_HUMAN;tr|E9PCX7|E9PCX7_HUMAN;tr|D6RHU2|D6RHU2_HUMAN;tr|D6RAI5|D6RAI5_HUMAN;tr|H0Y8P5|H0Y8P5_HUMAN;tr|D6RCR6|D6RCR6_HUMAN","sp|Q13423|NNTM_HUMAN;tr|E9PCX7|E9PCX7_HUMAN;tr|D6RHU2|D6RHU2_HUMAN;tr|D6RAI5|D6RAI5_HUMAN",1551,"Q13423","NNTM_HUMAN","NAD(P) transhydrogenase, mitochondrial",null,"NNT"]
["22.2079","21.881","21.7784","22.259",{"$nulls":3},"cell cycle;cell division;positive regulation of non-motile cilium assembly;protein heterooligomerization","cadherin binding;GTP binding;GTPase activity","actin cytoskeleton;axoneme;cytoplasm;microtubule;non-motile cilium;perinuclear region of cytoplasm;septin complex;stress fiber","Bacterial invasion of epithelial cells",null,null,22,22,22,"46.9","46.9","46.9","65.401",0,"166.49",1981800000,111,"0.0280653","0.967163","0.0257673","0.0886737","sp|Q9UHD8|SEPT9_HUMAN;tr|K7EL40|K7EL40_HUMAN;tr|K7EK18|K7EK18_HUMAN;tr|K7ER52|K7ER52_HUMAN;tr|K7EIE4|K7EIE4_HUMAN;tr|K7EQD7|K7EQD7_HUMAN;tr|K7ER14|K7ER14_HUMAN;tr|K7EJ51|K7EJ51_HUMAN;tr|K7ELJ9|K7ELJ9_HUMAN;tr|K7EJL9|K7EJL9_HUMAN;tr|K7EJZ2|K7EJZ2_HUMAN;tr|K7ENL0|K7ENL0_HUMAN;tr|K7EIR4|K7EIR4_HUMAN;tr|K7EKN4|K7EKN4_HUMAN;tr|K7EN52|K7EN52_HUMAN;tr|K7EJV0|K7EJV0_HUMAN;tr|K7ENQ5|K7ENQ5_HUMAN;tr|K7EPY1|K7EPY1_HUMAN;tr|K7ERG1|K7ERG1_HUMAN;tr|K7EQ08|K7EQ08_HUMAN;tr|K7ER34|K7ER34_HUMAN","sp|Q9UHD8|SEPT9_HUMAN",2831,"Q9UHD8","SEPT9_HUMAN","Septin-9",null,"SEPT9"]
["25.0382","24.9294","25.3761","24.5406",{"$nulls":3},"anion transport;apoptotic process;behavioral fear response;epithelial cell differentiation;learning;macroautophagy;mitochondrial calcium ion transmembrane transport;negative regulation of reactive oxygen species metabolic process;neuron-neuron synaptic transmission;regulation of autophagy of mitochondrion;viral process","identical protein binding;ion channel binding;porin activity;protein complex binding;protein kinase binding;voltage-gated anion channel activity","extracellular exosome;membrane;membrane raft;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrial outer membrane;mitochondrial permeability transition pore complex;mitochondrion;myelin sheath;nucleus;plasma membrane;pore complex;synaptic vesicle","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholesterol metabolism;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Necroptosis;NOD-like receptor signaling pathway;Parkinson disease",null,null,14,14,14,"59.7","59.7","59.7","30.772",0,"182.08",4965600000,132,"0.0189148","0.975711","0.0254164","0.0603259","sp|P21796|VDAC1_HUMAN;tr|C9JI87|C9JI87_HUMAN","sp|P21796|VDAC1_HUMAN;tr|C9JI87|C9JI87_HUMAN",756,"P21796","VDAC1_HUMAN","Voltage-dependent anion-selective channel protein 1","DAC-1;VDAC1","VDAC1"]
["17.4054","16.9386","17.545","16.7545",{"$nulls":4},"catalytic activity;metal ion binding",{"$nulls":4},2,2,2,"5.4","5.4","5.4","61.725","0.00040032","3.3686",35455000,5,"0.0151376","0.98007","0.0222511","0.0484726","tr|H0Y5G9|H0Y5G9_HUMAN;tr|G3V1R5|G3V1R5_HUMAN;tr|A0A087WYK8|A0A087WYK8_HUMAN;sp|O43847|NRDC_HUMAN;tr|B1AKJ5|B1AKJ5_HUMAN;tr|F5H7V1|F5H7V1_HUMAN","tr|H0Y5G9|H0Y5G9_HUMAN;tr|G3V1R5|G3V1R5_HUMAN;tr|A0A087WYK8|A0A087WYK8_HUMAN;sp|O43847|NRDC_HUMAN;tr|B1AKJ5|B1AKJ5_HUMAN;tr|F5H7V1|F5H7V1_HUMAN",272,"H0Y5G9","H0Y5G9_HUMAN",null,null,"NRDC"]
["19.7495","19.4984","20.2744","18.9303",{"$nulls":3},"early endosome to late endosome transport;endocytosis;synaptic vesicle to endosome fusion;vesicle fusion;viral RNA genome replication","1-phosphatidylinositol binding;calmodulin binding;GTP-dependent protein binding;nucleic acid binding;protein homodimerization activity;zinc ion binding","axonal spine;cytoplasm;cytosol;early endosome;early endosome membrane;extracellular exosome;extrinsic component of plasma membrane;membrane;presynapse;recycling endosome;serine-pyruvate aminotransferase complex","Endocytosis;Phagosome;Tuberculosis",null,null,17,17,17,16,16,16,"162.46",0,"179.62",624470000,81,"0.00980534","0.984111","0.0215893","0.0315797","sp|Q15075|EEA1_HUMAN","sp|Q15075|EEA1_HUMAN",1674,"Q15075","EEA1_HUMAN","Early endosome antigen 1",null,"EEA1"]
["17.7344","17.5806","18.0279","17.244",{"$nulls":3},"nervous system development","heparin binding;transition metal ion binding","integral component of membrane",{"$nulls":3},2,2,2,"3.6","3.6","3.6","75.109",0,"7.874",46324000,9,"0.0169068","0.977979","0.0215836","0.054036","tr|A0A0A0MRG2|A0A0A0MRG2_HUMAN;tr|E9PG40|E9PG40_HUMAN;sp|P05067|A4_HUMAN;tr|H7C0V9|H7C0V9_HUMAN","tr|A0A0A0MRG2|A0A0A0MRG2_HUMAN;tr|E9PG40|E9PG40_HUMAN;sp|P05067|A4_HUMAN;tr|H7C0V9|H7C0V9_HUMAN",509,"A0A0A0MRG2","A0A0A0MRG2_HUMAN",null,null,"APP"]
["16.7212","16.2791","16.6096","16.3478",{"$nulls":9},1,1,1,"7.9","7.9","7.9","54.027","0.0020921","2.2225",16650000,7,"0.0264009","0.967508","0.0214663","0.0835551","tr|G3V3Z8|G3V3Z8_HUMAN;sp|P49757|NUMB_HUMAN","tr|G3V3Z8|G3V3Z8_HUMAN;sp|P49757|NUMB_HUMAN",1093,"G3V3Z8","G3V3Z8_HUMAN",null,null,"NUMB"]
["17.7704","17.9775","18.2277","17.4773",{"$nulls":5},"intracellular membrane-bounded organelle;nucleoplasm;plasma membrane",{"$nulls":3},3,3,3,"8.4","8.4","8.4","82.89",0,"14.437",98288000,15,"0.0172513","0.977987","0.0214539","0.055117","tr|A0A087X0M4|A0A087X0M4_HUMAN;sp|Q9BWU0|NADAP_HUMAN;tr|H7C256|H7C256_HUMAN","tr|A0A087X0M4|A0A087X0M4_HUMAN;sp|Q9BWU0|NADAP_HUMAN",2489,"A0A087X0M4","A0A087X0M4_HUMAN",null,null,"SLC4A1AP"]
["17.8395","17.9282","17.9787","17.7478",{"$nulls":3},"cellular response to DNA damage stimulus;DNA ligation involved in DNA repair;double-strand break repair via nonhomologous end joining","identical protein binding;protein complex scaffold activity;protein homodimerization activity","extracellular exosome;nonhomologous end joining complex;nucleus;site of double-strand break",{"$nulls":3},1,1,1,"4.4","4.4","4.4","21.639","0.0097308","1.6704",24458000,3,"0.0540477","0.947288","0.0206051","0.166632","sp|Q9BUH6|PAXX_HUMAN","sp|Q9BUH6|PAXX_HUMAN",2454,"Q9BUH6","PAXX_HUMAN","Protein PAXX {ECO:0000305}",null,"PAXX"]
["18.9921","18.6016","19.4024","18.1515",{"$nulls":3},"autophagosome maturation;cellular response to starvation;chaperone-mediated autophagy;lysosomal protein catabolic process;muscle cell cellular homeostasis;negative regulation of protein homooligomerization;neutrophil degranulation;platelet degranulation;protein import;protein stabilization;protein targeting;protein targeting to lysosome involved in chaperone-mediated autophagy;regulation of protein stability","enzyme binding;protein domain specific binding","autolysosome;azurophil granule membrane;chaperone-mediated autophagy translocation complex;extracellular exosome;extracellular space;ficolin-1-rich granule membrane;integral component of autophagosome membrane;late endosome;late endosome membrane;lysosomal lumen;lysosomal membrane;lysosome;membrane;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;platelet dense granule membrane;trans-Golgi network","Autophagy - animal;Lysosome;Phagosome;Tuberculosis",null,null,1,1,1,"2.9","2.9","2.9","44.96",0,"5.1513",69286000,6,"0.0094267","0.984097","0.0199013","0.0303729","sp|P13473|LAMP2_HUMAN","sp|P13473|LAMP2_HUMAN",654,"P13473","LAMP2_HUMAN","Lysosome-associated membrane glycoprotein 2","AMP-2;ysosome-associated membrane protein 2","LAMP2"]
["14.8297","17.1454","14.2377","17.7021",{"$nulls":3},"gamma-aminobutyric acid receptor clustering;glycine receptor clustering;molybdenum incorporation into molybdenum-molybdopterin complex;molybdopterin cofactor biosynthetic process;Mo-molybdopterin cofactor biosynthetic process;response to metal ion","ATP binding;metal ion binding;molybdopterin adenylyltransferase activity;molybdopterin cofactor binding;molybdopterin molybdotransferase activity;nitrate reductase activity","cell junction;cytoplasm;cytoskeleton;dendrite;plasma membrane;postsynaptic membrane","Folate biosynthesis;GABAergic synapse;Metabolic pathways",null,null,2,2,2,"3.1","3.1","3.1","79.748",0,"13.753",48316000,7,"0.00260806","0.993716","0.017642","0.00846745","sp|Q9NQX3|GEPH_HUMAN;tr|F5H039|F5H039_HUMAN;tr|H0YJ30|H0YJ30_HUMAN;tr|G3V582|G3V582_HUMAN","sp|Q9NQX3|GEPH_HUMAN;tr|F5H039|F5H039_HUMAN;tr|H0YJ30|H0YJ30_HUMAN;tr|G3V582|G3V582_HUMAN",2674,"Q9NQX3","GEPH_HUMAN","Gephyrin {ECO:0000303|PubMed:10839351}",null,"GPHN"]
["14.8367","16.5163","16.6597","14.6588",{"$nulls":3},"carbohydrate metabolic process;O-glycan processing;protein O-linked glycosylation","carbohydrate binding;metal ion binding;polypeptide N-acetylgalactosaminyltransferase activity","extracellular exosome;Golgi membrane;integral component of membrane;membrane","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,2,2,2,"5.5","5.5","5.5","75.388","0.003771","2.0644",33933000,3,"0.00407365","0.991548","0.0172467","0.0132038","sp|Q86SF2|GALT7_HUMAN;tr|H0YAK0|H0YAK0_HUMAN;tr|E9PBY3|E9PBY3_HUMAN;tr|H0YAH3|H0YAH3_HUMAN","sp|Q86SF2|GALT7_HUMAN;tr|H0YAK0|H0YAK0_HUMAN;tr|E9PBY3|E9PBY3_HUMAN;tr|H0YAH3|H0YAH3_HUMAN",1967,"Q86SF2","GALT7_HUMAN","N-acetylgalactosaminyltransferase 7",null,"GALNT7"]
["16.8894","16.7297","17.1015","16.4855",{"$nulls":4},"metal ion binding",{"$nulls":4},1,1,1,"4.3","4.3","4.3","57.427",0,"22.329",25078000,9,"0.0157652","0.978636","0.0160532","0.0504484","tr|E9PBY7|E9PBY7_HUMAN;tr|E9PQ61|E9PQ61_HUMAN;sp|O75152|ZC11A_HUMAN","tr|E9PBY7|E9PBY7_HUMAN;tr|E9PQ61|E9PQ61_HUMAN;sp|O75152|ZC11A_HUMAN",324,"E9PBY7","E9PBY7_HUMAN",null,null,"ZC3H11A"]
["23.5221","23.1765","23.6128","23.0539",{"$nulls":3},"response to ethanol;translational elongation","GTP binding;GTPase activity;RNA binding;translation elongation factor activity","extracellular exosome;membrane;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrion;myelin sheath",{"$nulls":3},15,15,15,"37.8","37.8","37.8","49.541",0,"107.08",2584100000,102,"0.0151223","0.979726","0.0159092","0.0484244","sp|P49411|EFTU_HUMAN;tr|H3BNU3|H3BNU3_HUMAN","sp|P49411|EFTU_HUMAN",1077,"P49411","EFTU_HUMAN","Elongation factor Tu, mitochondrial","F-Tu","TUFM"]
["21.0959","21.034","21.5961","20.504",{"$nulls":5},"cytosol;nucleolus;nucleus",{"$nulls":3},10,10,9,"25.3","25.3","23.3","63.138",0,"297.87",734950000,52,"0.00847598","0.984177","0.0149517","0.0273382","tr|Q5H909|Q5H909_HUMAN;sp|Q9UNF1|MAGD2_HUMAN;tr|Q5H907|Q5H907_HUMAN","tr|Q5H909|Q5H909_HUMAN;sp|Q9UNF1|MAGD2_HUMAN;tr|Q5H907|Q5H907_HUMAN",2910,"Q5H909","Q5H909_HUMAN",null,null,"MAGED2"]
["15.2606",1,"15.2308",1,{"$nulls":3},"development of secondary female sexual characteristics;negative regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter","metal ion binding","extracellular space;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"1.9","1.9","1.9","82.658","0.00039588","3.2978",6376500,1,"0.000454179","0.999614","0.0148902","0.00147819","sp|Q9H1B7|I2BPL_HUMAN","sp|Q9H1B7|I2BPL_HUMAN",2568,"Q9H1B7","I2BPL_HUMAN","Interferon regulatory factor 2-binding protein-like",null,"IRF2BPL"]
["21.7864","21.7551","22.2355","21.2769",{"$nulls":3},"regulation of transcription, DNA-templated","metal ion binding;RNA binding","nucleolus;nucleus",{"$nulls":3},3,3,3,"7.6","7.6","7.6","64.929",0,"11.336",556300000,19,"0.00943369","0.984439","0.014576","0.0303952","tr|B0QYK0|B0QYK0_HUMAN;sp|Q01844|EWS_HUMAN;tr|H7BY36|H7BY36_HUMAN;tr|A0A0D9SFL3|A0A0D9SFL3_HUMAN;tr|C9JGE3|C9JGE3_HUMAN","tr|B0QYK0|B0QYK0_HUMAN;sp|Q01844|EWS_HUMAN;tr|H7BY36|H7BY36_HUMAN;tr|A0A0D9SFL3|A0A0D9SFL3_HUMAN;tr|C9JGE3|C9JGE3_HUMAN",1422,"B0QYK0","B0QYK0_HUMAN",null,null,"EWSR1"]
["17.3119","16.9056","17.2836","16.9064",{"$nulls":3},"metabolic process","hydrolase activity;metal ion binding",{"$nulls":4},3,1,1,"13.4","5.4","5.4","34.613","0.00038625","3.0664",13014000,5,"0.015532","0.978964","0.0137806","0.0497144","sp|Q6P2I3|FAH2B_HUMAN;tr|C9J5B6|C9J5B6_HUMAN;tr|C9JGM0|C9JGM0_HUMAN","sp|Q6P2I3|FAH2B_HUMAN",1886,"Q6P2I3","FAH2B_HUMAN","Fumarylacetoacetate hydrolase domain-containing protein 2B",null,"FAHD2B"]
["21.3466","21.3726","20.998","21.6939",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;associative learning;asymmetric cell division;cellular response to interferon-gamma;cellular response to trichostatin A;cilium assembly;cytosolic transport;ephrin receptor signaling pathway;establishment or maintenance of cell polarity;Fc-gamma receptor signaling pathway involved in phagocytosis;meiotic chromosome movement towards spindle pole;meiotic cytokinesis;membrane organization;movement of cell or subcellular component;neutrophil degranulation;positive regulation of dendritic spine morphogenesis;response to ethanol;response to immobilization stress;spindle localization","actin binding;ATP binding;structural constituent of cytoskeleton","actin cap;actin cytoskeleton;Arp2/3 protein complex;azurophil granule lumen;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;invadopodium;lamellipodium;membrane;podosome core;postsynaptic density","Tight junction;Yersinia infection",null,null,4,4,4,"13.5","13.5","13.5","44.76",0,"13.086",352840000,14,"0.0122325","0.981644","0.0136824","0.0392926","sp|P61160|ARP2_HUMAN;tr|F5H6T1|F5H6T1_HUMAN","sp|P61160|ARP2_HUMAN;tr|F5H6T1|F5H6T1_HUMAN",1260,"P61160","ARP2_HUMAN","Actin-related protein 2",null,"ACTR2"]
["21.318","21.0822","21.6282","20.7461",{"$nulls":5},"nuclear membrane;nucleoplasm",{"$nulls":3},7,7,7,"13.5","13.5","13.5","58.634",0,"20.312",393670000,12,"0.00878929","0.984166","0.0129385","0.028339","tr|F2Z2V0|F2Z2V0_HUMAN;sp|Q99829|CPNE1_HUMAN;tr|B0QZ18|B0QZ18_HUMAN;tr|A6PVH9|A6PVH9_HUMAN;tr|E7ENH5|E7ENH5_HUMAN;tr|Q5JX58|Q5JX58_HUMAN;tr|Q5JX59|Q5JX59_HUMAN;tr|Q5JX60|Q5JX60_HUMAN;tr|Q5JX44|Q5JX44_HUMAN;tr|Q5JX55|Q5JX55_HUMAN;tr|Q5JX56|Q5JX56_HUMAN;tr|H0Y524|H0Y524_HUMAN;tr|Q5JX45|Q5JX45_HUMAN;tr|Q5JX54|Q5JX54_HUMAN;tr|Q5JX61|Q5JX61_HUMAN;tr|Q5JX52|Q5JX52_HUMAN","tr|F2Z2V0|F2Z2V0_HUMAN;sp|Q99829|CPNE1_HUMAN;tr|B0QZ18|B0QZ18_HUMAN;tr|A6PVH9|A6PVH9_HUMAN;tr|E7ENH5|E7ENH5_HUMAN",2399,"F2Z2V0","F2Z2V0_HUMAN",null,null,"CPNE1"]
["15.9925","16.0856","16.5821","15.4705",{"$nulls":4},"ATP binding","intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},4,4,4,3,3,3,"206.93",0,"7.8385",53643000,6,"0.007072","0.986407","0.0127416","0.0228454","tr|A0A0A0MTH9|A0A0A0MTH9_HUMAN;sp|O14981|BTAF1_HUMAN","tr|A0A0A0MTH9|A0A0A0MTH9_HUMAN;sp|O14981|BTAF1_HUMAN",189,"A0A0A0MTH9","A0A0A0MTH9_HUMAN",null,null,"BTAF1"]
["18.3502","18.2378","18.923","17.6408",{"$nulls":3},"cell proliferation;mRNA processing;negative regulation of protein dephosphorylation;regulation of transcription, DNA-templated;RNA catabolic process;RNA splicing;transcription, DNA-templated","DNA binding;endonuclease activity;mRNA binding;protein serine/threonine phosphatase inhibitor activity;ribonuclease E activity;RNA binding","cytoplasm;nuclear speck;nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},3,3,3,16,16,16,"38.478",0,"5.1357",38160000,7,"0.00583744","0.988573","0.0121527","0.0188832","sp|Q12972|PP1R8_HUMAN;tr|A0A0A0MT09|A0A0A0MT09_HUMAN","sp|Q12972|PP1R8_HUMAN;tr|A0A0A0MT09|A0A0A0MT09_HUMAN",1509,"Q12972","PP1R8_HUMAN","Nuclear inhibitor of protein phosphatase 1","IPP-1","PPP1R8"]
["24.6138","24.0094","24.5154","24.0876",{"$nulls":3},"aldehyde catabolic process;angiogenesis;canonical glycolysis;carbohydrate metabolic process;erythrocyte homeostasis;gluconeogenesis;glucose 6-phosphate metabolic process;glucose homeostasis;hemostasis;humoral immune response;in utero embryonic development;learning or memory;mesoderm formation;methylglyoxal biosynthetic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of neuron apoptotic process;neutrophil degranulation;positive regulation of immunoglobulin secretion;response to cadmium ion;response to estradiol;response to immobilization stress;response to morphine;response to muscle stretch;response to progesterone;response to testosterone","cytokine activity;glucose-6-phosphate isomerase activity;growth factor activity;intramolecular transferase activity;monosaccharide binding;ubiquitin protein ligase binding","ciliary membrane;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;myelin sheath;neuron projection;nucleoplasm;plasma membrane;secretory granule lumen","Amino sugar and nucleotide sugar metabolism;Carbon metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways;Pentose phosphate pathway;Starch and sucrose metabolism",null,null,16,16,11,"36.6","36.6","24.4","63.146",0,"323.31",5886100000,160,"0.00845106","0.983837","0.0100918","0.0272586","sp|P06744|G6PI_HUMAN;tr|A0A0A0MTS2|A0A0A0MTS2_HUMAN;tr|K7EQ48|K7EQ48_HUMAN;tr|A0A0J9YXP8|A0A0J9YXP8_HUMAN;tr|A0A0J9YYH3|A0A0J9YYH3_HUMAN;tr|A0A0J9YX90|A0A0J9YX90_HUMAN;tr|K7EPY4|K7EPY4_HUMAN;tr|K7EP41|K7EP41_HUMAN;tr|K7ENA0|K7ENA0_HUMAN;tr|K7ERC6|K7ERC6_HUMAN;tr|K7ELR7|K7ELR7_HUMAN;tr|K7EIL4|K7EIL4_HUMAN;tr|K7ERK8|K7ERK8_HUMAN","sp|P06744|G6PI_HUMAN;tr|A0A0A0MTS2|A0A0A0MTS2_HUMAN;tr|K7EQ48|K7EQ48_HUMAN;tr|A0A0J9YXP8|A0A0J9YXP8_HUMAN;tr|A0A0J9YYH3|A0A0J9YYH3_HUMAN;tr|A0A0J9YX90|A0A0J9YX90_HUMAN",534,"P06744","G6PI_HUMAN","Glucose-6-phosphate isomerase","PI","GPI"]
["16.0266","15.7318","16.614","15.1277",{"$nulls":3},"signal transduction",null,"membrane;plasma membrane",{"$nulls":3},2,2,2,"7.3","7.3","7.3","68.249",0,"4.1154",24224000,4,"0.00341084","0.991529","0.00838184","0.0110637","sp|Q9H9A6|LRC40_HUMAN","sp|Q9H9A6|LRC40_HUMAN",2620,"Q9H9A6","LRC40_HUMAN","Leucine-rich repeat-containing protein 40",null,"LRRC40"]
["23.2155","23.0621","23.2433","23.0177",{"$nulls":3},"chemical synaptic transmission;G-protein coupled receptor signaling pathway;muscle contraction;regulation of blood pressure;regulation of blood vessel diameter","hormone activity;receptor binding","extracellular region;extracellular space","Neuroactive ligand-receptor interaction",null,null,1,1,1,"6.5","6.5","6.5","14.295","0.0041012","2.0499",622560000,10,"0.0190564","0.976201","0.00829124","0.0607684","sp|O95399|UTS2_HUMAN;tr|Q5H8X8|Q5H8X8_HUMAN","sp|O95399|UTS2_HUMAN;tr|Q5H8X8|Q5H8X8_HUMAN",433,"O95399","UTS2_HUMAN","Urotensin-2",null,"UTS2"]
["18.1483","17.9439","18.0483","18.028",{"$nulls":3},"endocytic recycling;endosome organization;Golgi ribbon formation;Golgi vesicle transport;intracellular protein transport;regulation of cellular protein localization;regulation of protein localization;retrograde transport, endosome to Golgi;vesicle docking;vesicle fusion","SNAP receptor activity;syntaxin binding","clathrin-coated vesicle;cytosol;early endosome;Golgi apparatus;Golgi membrane;integral component of membrane;integral component of synaptic vesicle membrane;nucleoplasm;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;SNARE complex;terminal bouton;trans-Golgi network;trans-Golgi network membrane","SNARE interactions in vesicular transport",null,null,2,2,2,"16.9","16.9","16.9","29.176",0,"5.3222",27779000,12,"0.0243334","0.970442","0.00792408","0.0771737","sp|O43752|STX6_HUMAN","sp|O43752|STX6_HUMAN",264,"O43752","STX6_HUMAN","Syntaxin-6",null,"STX6"]
["15.974","15.5507","16.6389","14.8738",{"$nulls":3},"cell morphogenesis;cell proliferation;ceramide metabolic process;endoplasmic reticulum organization;ER to Golgi ceramide transport;heart morphogenesis;immune response;in utero embryonic development;intermembrane sphingolipid transfer;lipid homeostasis;mitochondrion morphogenesis;muscle contraction;response to endoplasmic reticulum stress;signal transduction;sphingolipid biosynthetic process","ceramide binding;intermembrane ceramide transfer activity;kinase activity;phosphatidylinositol-4-phosphate binding","cytosol;endoplasmic reticulum membrane;Golgi apparatus;intracellular;mitochondrion;nucleoplasm",{"$nulls":3},1,1,1,"2.1","2.1","2.1","70.834","0.0030992","2.1104",18827000,4,"0.00204918","0.995055","0.006042","0.0066572","sp|Q9Y5P4|C43BP_HUMAN","sp|Q9Y5P4|C43BP_HUMAN",3023,"Q9Y5P4","C43BP_HUMAN","Collagen type IV alpha-3-binding protein",null,"COL4A3BP"]
["24.6974","24.4945","24.8569","24.3238",{"$nulls":3},"actin cytoskeleton reorganization;actin filament-based movement;actomyosin structure organization;angiogenesis;blood vessel endothelial cell migration;cytokinetic process;establishment of meiotic spindle localization;establishment of T cell polarity;in utero embryonic development;integrin-mediated signaling pathway;leukocyte migration;meiotic spindle organization;membrane protein ectodomain proteolysis;monocyte differentiation;myoblast fusion;negative regulation of actin filament severing;phagocytosis, engulfment;platelet aggregation;platelet formation;positive regulation of protein processing in phagocytic vesicle;protein transport;regulation of cell shape;uropod organization","actin binding;actin filament binding;actin-dependent ATPase activity;ADP binding;ATP binding;ATPase activity;cadherin binding;calmodulin binding;microfilament motor activity;motor activity;protein domain specific binding;protein homodimerization activity;protein membrane anchor;RNA binding","actin cytoskeleton;actomyosin;actomyosin contractile ring;brush border;cell leading edge;cell-cell adherens junction;cleavage furrow;cytoplasm;cytosol;extracellular exosome;extracellular matrix;focal adhesion;immunological synapse;membrane;myosin II complex;myosin II filament;neuromuscular junction;nucleus;plasma membrane;protein complex;ruffle;spindle;stress fiber;uropod","Regulation of actin cytoskeleton;Tight junction",null,null,87,87,76,"48.7","48.7","43.1","226.53",0,"323.31",29876000000,704,"0.00606206","0.988527","0.00559139","0.0196049","sp|P35579|MYH9_HUMAN;sp|P35749|MYH11_HUMAN;tr|B1PS43|B1PS43_HUMAN;tr|Q5BKV1|Q5BKV1_HUMAN;tr|B1AH99|B1AH99_HUMAN;tr|A0A0C4DFM8|A0A0C4DFM8_HUMAN;tr|A1L2Z2|A1L2Z2_HUMAN;REV__tr|S4R3H4|S4R3H4_HUMAN;REV__tr|E7EQT4|E7EQT4_HUMAN;REV__sp|Q9UKV3|ACINU_HUMAN","sp|P35579|MYH9_HUMAN",932,"P35579","MYH9_HUMAN","Myosin-9",null,"MYH9"]
["20.8993","21.0143","21.547","20.3561",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","enzyme regulator activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region;membrane;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle;proteasome regulatory particle, base subcomplex;proteasome storage granule","Epstein-Barr virus infection;Proteasome",null,null,17,17,17,"25.4","25.4","25.4","105.84",0,"88.885",1120400000,97,"0.00271714","0.99303","0.00527668","0.00882049","sp|Q99460|PSMD1_HUMAN;tr|A0A087WW66|A0A087WW66_HUMAN;tr|C9J9M4|C9J9M4_HUMAN;tr|H7BZR6|H7BZR6_HUMAN;tr|F8WCE3|F8WCE3_HUMAN;tr|H7C378|H7C378_HUMAN","sp|Q99460|PSMD1_HUMAN;tr|A0A087WW66|A0A087WW66_HUMAN",2373,"Q99460","PSMD1_HUMAN","26S proteasome non-ATPase regulatory subunit 1",null,"PSMD1"]
["18.4302","18.1338","18.3717","18.1831",{"$nulls":3},"positive regulation of rRNA processing;positive regulation of transcription from RNA polymerase I promoter;rRNA processing;transcription, DNA-templated","RNA binding","fibrillar center;nucleolus;nucleoplasm","Ribosome biogenesis in eukaryotes",null,null,2,2,2,"3.4","3.4","3.4","74.89",0,"21.767",89431000,9,"0.00815709","0.984053","0.00462437","0.026319","sp|Q15061|WDR43_HUMAN","sp|Q15061|WDR43_HUMAN",1671,"Q15061","WDR43_HUMAN","WD repeat-containing protein 43",null,"WDR43"]
["16.4534","16.8338","16.9652","16.3136",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;RNA phosphodiester bond hydrolysis, endonucleolytic;RNA processing","double-stranded RNA binding;ribonuclease III activity;RNA binding","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion;nucleus;plasma membrane",{"$nulls":3},1,1,1,"5.7","5.7","5.7","37.535",0,"3.7714",16943000,9,"0.00340732","0.99119","0.00416946","0.0110523","sp|Q9H9J2|RM44_HUMAN","sp|Q9H9J2|RM44_HUMAN",2624,"Q9H9J2","RM44_HUMAN","39S ribosomal protein L44, mitochondrial","44mt;RP-L44","MRPL44"]
["19.3377",1,"19.3316",1,{"$nulls":3},"translation",{"$nulls":5},1,1,1,6,6,6,"20.838",0,"5.5617",34553000,2,"0.0000723612",1,"0.00305462","0.000235614","tr|J3QKW2|J3QKW2_HUMAN;sp|Q9Y2R9|RT07_HUMAN;tr|J3QLS3|J3QLS3_HUMAN","tr|J3QKW2|J3QKW2_HUMAN;sp|Q9Y2R9|RT07_HUMAN;tr|J3QLS3|J3QLS3_HUMAN",2954,"J3QKW2","J3QKW2_HUMAN",null,null,"MRPS7"]
["17.4935","16.4029","16.8775","17.0137",{"$nulls":4},"ATP binding;MAP kinase activity","nuclear speck",{"$nulls":3},2,2,2,"16.6","16.6","16.6","32.357","0.0037775","2.0753",13785000,4,"0.00148147","0.995843","0.00264645","0.004816","tr|B4E0K5|B4E0K5_HUMAN;sp|Q16539|MK14_HUMAN;tr|E7EX54|E7EX54_HUMAN","tr|B4E0K5|B4E0K5_HUMAN;sp|Q16539|MK14_HUMAN;tr|E7EX54|E7EX54_HUMAN",1740,"B4E0K5","B4E0K5_HUMAN","Mitogen-activated protein kinase {ECO:0000256|SAAS:SAAS00373405}",null,"MAPK14"]
["21.7374","22.1588","22.2185","21.6725",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;proteolysis;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","ATPase activity;enzyme regulator activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;proteasome accessory complex;proteasome complex;proteasome regulatory particle;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,8,8,8,"24.2","24.2","24.2","45.531",0,"72.297",1059400000,27,"0.00231176","0.994059","0.00258923","0.00750799","sp|Q15008|PSMD6_HUMAN;tr|C9J7B7|C9J7B7_HUMAN;tr|C9J0E9|C9J0E9_HUMAN;tr|H7C531|H7C531_HUMAN","sp|Q15008|PSMD6_HUMAN",1660,"Q15008","PSMD6_HUMAN","26S proteasome non-ATPase regulatory subunit 6",null,"PSMD6"]
["16.3864","17.4795","16.938","16.9234",{"$nulls":4},"ATP binding;non-membrane spanning protein tyrosine kinase activity;protein kinase activity",{"$nulls":4},6,6,6,"6.3","6.3","6.3","149.62",0,"19.334",103430000,12,"0.00128299","0.995663","0.00228024","0.0041717","sp|Q86YV5|SG223_HUMAN","sp|Q86YV5|SG223_HUMAN",2004,"Q86YV5","PRAG1_HUMAN","Tyrosine-protein kinase PRAG1 {ECO:0000312|HGNC:HGNC:25438}",null,"PRAG1"]
["16.0348","16.8467","16.6828","16.1944",{"$nulls":3},"apoptotic process;circadian regulation of gene expression;histone H3-K4 trimethylation;histone H4-K16 acetylation;histone H4-K5 acetylation;histone H4-K8 acetylation;negative regulation of protein ubiquitination;phosphatidylinositol-mediated signaling;positive regulation of histone H3-K27 methylation;positive regulation of proteolysis;positive regulation of transcription from RNA polymerase II promoter;protein deubiquitination;protein O-linked glycosylation;protein processing;regulation of gluconeogenesis involved in cellular glucose homeostasis;regulation of glycolytic process;regulation of insulin receptor signaling pathway;regulation of Rac protein signal transduction;response to insulin;response to nutrient;signal transduction","acetylglucosaminyltransferase activity;phosphatidylinositol-3,4,5-trisphosphate binding;protein N-acetylglucosaminyltransferase activity;protein O-GlcNAc transferase activity","cytosol;histone acetyltransferase complex;mitochondrion;nucleoplasm;nucleus;plasma membrane","Insulin resistance;Other types of O-glycan biosynthesis",null,null,5,5,5,"7.7","7.7","7.7","116.92",0,"12.569",56646000,14,"0.0013975","0.995476","0.00215244","0.00454345","sp|O15294|OGT1_HUMAN","sp|O15294|OGT1_HUMAN",211,"O15294","OGT1_HUMAN","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit",null,"OGT"]
["20.1981","19.7916","20.1284","19.8582",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},1,1,1,"26.5","26.5","26.5","7.624","0.0011228","2.788",42459000,9,"0.00197497","0.995057","0.00156593","0.00641664","tr|C9J4Z3|C9J4Z3_HUMAN;sp|P61513|RL37A_HUMAN","tr|C9J4Z3|C9J4Z3_HUMAN;sp|P61513|RL37A_HUMAN",1273,"C9J4Z3","C9J4Z3_HUMAN"]
["17.0633","16.6921","17.2127","16.5398",{"$nulls":3},"endocytosis;endosome to lysosome transport;endosome transport via multivesicular body sorting pathway;extrinsic apoptotic signaling pathway via death domain receptors;glucose import;Golgi to endosome transport;G-protein coupled receptor signaling pathway;multicellular organism development;myotube differentiation;negative regulation of fat cell differentiation;negative regulation of lipoprotein lipase activity;neuropeptide signaling pathway;neurotrophin TRK receptor signaling pathway;ossification;plasma membrane to endosome transport;positive regulation of epithelial cell apoptotic process;regulation of gene expression;response to insulin;vesicle organization","enzyme binding;nerve growth factor binding;nerve growth factor receptor activity;neurotensin receptor activity, non-G-protein coupled","cell surface;clathrin-coated pit;clathrin-coated vesicle;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;dendrite;early endosome;endoplasmic reticulum membrane;endosome membrane;Golgi apparatus;Golgi cisterna membrane;integral component of membrane;lysosomal membrane;neuronal cell body;nuclear membrane;perinuclear region of cytoplasm;plasma membrane;trans-Golgi network transport vesicle","Cholesterol metabolism;Lysosome;Neurotrophin signaling pathway",null,null,2,2,2,"3.5","3.5","3.5","92.067",0,"3.7491",37675000,7,"0.00117151","0.996129","0.00146389","0.0038097","sp|Q99523|SORT_HUMAN;tr|A0A0J9YVX1|A0A0J9YVX1_HUMAN;tr|A0A0J9YX61|A0A0J9YX61_HUMAN","sp|Q99523|SORT_HUMAN;tr|A0A0J9YVX1|A0A0J9YVX1_HUMAN;tr|A0A0J9YX61|A0A0J9YX61_HUMAN",2378,"Q99523","SORT_HUMAN","Sortilin",null,"SORT1"]
["18.3035",1,"18.301",1,{"$nulls":4},"ATP binding;MAP kinase activity","intracellular",{"$nulls":3},3,1,1,"12.3","4.4","4.4","35.737","0.00039952","3.3598",32864000,1,"0.0000313594","0.999902","0.00124931","0.000102113","tr|E9PJF0|E9PJF0_HUMAN;tr|E9PQW4|E9PQW4_HUMAN;sp|P27361|MK03_HUMAN;tr|H0YDH9|H0YDH9_HUMAN;tr|B3KR49|B3KR49_HUMAN;tr|E9PBK7|E9PBK7_HUMAN;tr|K7ELV1|K7ELV1_HUMAN;tr|K7EN18|K7EN18_HUMAN;sp|P31152|MK04_HUMAN;sp|Q16659|MK06_HUMAN","tr|E9PJF0|E9PJF0_HUMAN;tr|E9PQW4|E9PQW4_HUMAN;sp|P27361|MK03_HUMAN;tr|H0YDH9|H0YDH9_HUMAN;tr|B3KR49|B3KR49_HUMAN;tr|E9PBK7|E9PBK7_HUMAN",821,"E9PJF0","E9PJF0_HUMAN","Mitogen-activated protein kinase {ECO:0000256|RuleBase:RU361165, ECO:0000256|SAAS:SAAS00652812}",null,"MAPK3"]
["24.3915","24.0276","24.5209","23.8988",{"$nulls":3},"cell redox homeostasis;cellular oxidant detoxification;cellular response to oxidative stress;glycerophospholipid catabolic process;hydrogen peroxide catabolic process;neutrophil degranulation;positive regulation of mRNA splicing, via spliceosome;response to oxidative stress","cadherin binding;calcium-independent phospholipase A2 activity;glutathione peroxidase activity;peroxiredoxin activity;phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine);phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine);protein homodimerization activity;ubiquitin protein ligase binding","azurophil granule lumen;cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;membrane;nucleus;perinuclear region of cytoplasm","Metabolic pathways",null,null,13,13,13,71,71,71,"25.035",0,"80.078",3190600000,78,"0.000300816","0.999071","-0.000352859","-0.000979223","sp|P30041|PRDX6_HUMAN","sp|P30041|PRDX6_HUMAN",855,"P30041","PRDX6_HUMAN","Peroxiredoxin-6",null,"PRDX6"]
["20.1559","19.8706","20.5091","19.5187",{"$nulls":4},"ATP binding","mitochondrion",{"$nulls":3},5,5,0,"13.1","13.1",0,"64.243",0,"75.084",322670000,19,"0.000405941","0.99941","-0.000680923","-0.00132127","tr|H0Y2W2|H0Y2W2_HUMAN;tr|J3QSF3|J3QSF3_HUMAN;sp|Q5T2N8|ATD3C_HUMAN","tr|H0Y2W2|H0Y2W2_HUMAN",3100,"H0Y2W2","H0Y2W2_HUMAN",null,null,"ATAD3A"]
["23.3534","23.5367","23.3573","23.5398",{"$nulls":3},"base-excision repair;DNA unwinding involved in DNA replication;establishment of integrated proviral latency;negative regulation of cell proliferation;negative regulation of chromatin silencing;negative regulation of transcription, DNA-templated;nuclear transport;nucleosome disassembly;oncogene-induced cell senescence;positive regulation of cellular senescence;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;protein complex assembly;regulation of transcription, DNA-templated;response to virus;senescence-associated heterochromatin focus assembly","5'-deoxyribose-5-phosphate lyase activity;AT DNA binding;chromatin binding;DNA binding;DNA binding transcription factor activity;DNA-(apurinic or apyrimidinic site) lyase activity;enhancer sequence-specific DNA binding;enzyme binding;ligand-dependent nuclear receptor transcription coactivator activity;peroxisome proliferator activated receptor binding;retinoic acid receptor binding;retinoid X receptor binding;transcription factor binding;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding","cytosol;focal adhesion;nucleoplasm;nucleus;RNA polymerase II transcription factor complex;senescence-associated heterochromatin focus;transcription factor complex",{"$nulls":3},4,4,4,"37.4","37.4","37.4","11.676",0,"11.329",497220000,26,"0.00836426","0.983654","-0.00348949","-0.0269812","sp|P17096|HMGA1_HUMAN","sp|P17096|HMGA1_HUMAN",704,"P17096","HMGA1_HUMAN","High mobility group protein HMG-I/HMG-Y","MG-I(Y)","HMGA1"]
["19.7705","20.3308","20.3696","19.7411",{"$nulls":3},"blastocyst development;cell cycle;cell proliferation;DNA replication;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;histone exchange;male gonad development;nucleosome assembly;protein transport;response to testosterone","histone binding;Hsp90 protein binding;protein complex binding","cytoplasm;nuclear chromatin;nucleoplasm;nucleus;protein complex",{"$nulls":3},12,12,12,"21.2","21.2","21.2","85.237",0,"41.202",440470000,32,"0.00344427","0.991869","-0.00470352","-0.0111717","sp|P49321|NASP_HUMAN;tr|E9PPR5|E9PPR5_HUMAN;tr|E9PRH9|E9PRH9_HUMAN;tr|Q5T624|Q5T624_HUMAN;tr|E9PI86|E9PI86_HUMAN;tr|H0YF33|H0YF33_HUMAN;tr|H0YDS9|H0YDS9_HUMAN;tr|E9PQG5|E9PQG5_HUMAN;tr|E9PAU3|E9PAU3_HUMAN;tr|E9PKR5|E9PKR5_HUMAN;tr|E9PNB5|E9PNB5_HUMAN;tr|E9PPQ8|E9PPQ8_HUMAN","sp|P49321|NASP_HUMAN;tr|E9PPR5|E9PPR5_HUMAN",1070,"P49321","NASP_HUMAN","Nuclear autoantigenic sperm protein","ASP","NASP"]
["20.2602","20.1998","20.1274","20.3446",{"$nulls":3},"chromosome organization;ITP catabolic process;nucleoside triphosphate catabolic process;purine nucleotide catabolic process","dITP diphosphatase activity;identical protein binding;ITP diphosphatase activity;metal ion binding;NADH pyrophosphatase activity;nucleoside-triphosphate diphosphatase activity;nucleotide binding;XTP diphosphatase activity","cytoplasm;cytosol","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism",null,null,3,3,3,"19.6","19.6","19.6","21.445",0,"3.5334",81476000,11,"0.0167937","0.97729","-0.00605106","-0.0536808","sp|Q9BY32|ITPA_HUMAN","sp|Q9BY32|ITPA_HUMAN",2503,"Q9BY32","ITPA_HUMAN","Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}","nosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148};TPase {ECO:0000255|HAMAP-Rule:MF_03148}","ITPA"]
["17.7016","17.9","17.2948","18.3225",{"$nulls":3},"cellular protein modification process;mRNA processing;regulation of double-strand break repair via homologous recombination;RNA splicing","protein binding, bridging;protein phosphatase regulator activity","centrosome;cytoplasm;nucleoplasm;nucleus;protein phosphatase 4 complex",{"$nulls":3},3,3,3,"15.3","15.3","15.3","46.898",0,"7.9085",49714000,13,"0.00464131","0.990391","-0.00786781","-0.0150341","sp|Q9NY27|PP4R2_HUMAN;tr|C9IZ04|C9IZ04_HUMAN;tr|F8WDK3|F8WDK3_HUMAN;tr|H7C559|H7C559_HUMAN","sp|Q9NY27|PP4R2_HUMAN;tr|C9IZ04|C9IZ04_HUMAN",2745,"Q9NY27","PP4R2_HUMAN","Serine/threonine-protein phosphatase 4 regulatory subunit 2",null,"PPP4R2"]
["16.7886","16.8139","16.7227","16.8957",{"$nulls":3},"mRNA processing;regulation of alternative mRNA splicing, via spliceosome;regulation of apoptotic process;RNA splicing","mRNA binding;RNA binding","cytoplasm;nuclear speck;spliceosomal complex","Spliceosome",null,null,1,1,1,"1.7","1.7","1.7","100.18",0,"5.3666",26997000,5,"0.0286515","0.967159","-0.00790977","-0.0904728","sp|P49756|RBM25_HUMAN","sp|P49756|RBM25_HUMAN",1092,"P49756","RBM25_HUMAN","RNA-binding protein 25",null,"RBM25"]
["20.9647","20.4028","21.1273","20.2563",{"$nulls":3},"branched-chain amino acid biosynthetic process;branched-chain amino acid catabolic process;cellular response to leukemia inhibitory factor;isoleucine catabolic process;leucine biosynthetic process;regulation of hormone levels;valine biosynthetic process","branched-chain-amino-acid transaminase activity;L-isoleucine transaminase activity;L-leucine transaminase activity;L-valine transaminase activity","mitochondrial matrix;mitochondrion","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Cysteine and methionine metabolism;Metabolic pathways;Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine biosynthesis;Valine, leucine and isoleucine degradation",null,null,4,4,4,"18.6","18.6","18.6","44.287",0,"48.845",274720000,18,"0.00479436","0.990941","-0.0080471","-0.0155272","sp|O15382|BCAT2_HUMAN;tr|M0QZ10|M0QZ10_HUMAN;tr|M0QXF9|M0QXF9_HUMAN;tr|M0QZP4|M0QZP4_HUMAN;tr|B3KSI3|B3KSI3_HUMAN","sp|O15382|BCAT2_HUMAN;tr|M0QZ10|M0QZ10_HUMAN;tr|M0QXF9|M0QXF9_HUMAN;tr|M0QZP4|M0QZP4_HUMAN;tr|B3KSI3|B3KSI3_HUMAN",219,"O15382","BCAT2_HUMAN","Branched-chain-amino-acid aminotransferase, mitochondrial","CAT(m)","BCAT2"]
["19.4895","19.1566","19.3748","19.2876",{"$nulls":3},"glycosphingolipid metabolic process;intracellular protein transport;negative regulation of chaperone-mediated autophagy;neutrophil degranulation;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of chaperone-mediated autophagy;regulation of protein stability","carboxypeptidase activity;enzyme activator activity;exo-alpha-sialidase activity;serine-type carboxypeptidase activity","azurophil granule lumen;endoplasmic reticulum;extracellular exosome;extracellular region;intracellular membrane-bounded organelle;lysosomal lumen;lysosome;membrane;nucleoplasm","Lysosome;Renin-angiotensin system",null,null,3,3,3,"6.7","6.7","6.7","54.465",0,"5.1176",94645000,6,"0.0146994","0.980053","-0.00810242","-0.0470915","sp|P10619|PPGB_HUMAN;tr|X6R5C5|X6R5C5_HUMAN;tr|X6R8A1|X6R8A1_HUMAN","sp|P10619|PPGB_HUMAN;tr|X6R5C5|X6R5C5_HUMAN;tr|X6R8A1|X6R8A1_HUMAN",609,"P10619","PPGB_HUMAN","Lysosomal protective protein",null,"CTSA"]
["17.5582","18.6612","18.1638","18.0723",{"$nulls":3},"maturation of LSU-rRNA;positive regulation of cell proliferation;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;ribosomal large subunit assembly;rRNA base methylation","RNA binding;rRNA (cytosine-C5-)-methyltransferase activity","nucleolus;nucleoplasm",{"$nulls":3},3,3,3,"5.2","5.2","5.2","89.301",0,"18.25",71449000,15,"0.00466413","0.990731","-0.00836086","-0.0151076","sp|P46087|NOP2_HUMAN;tr|A0A087WV73|A0A087WV73_HUMAN;tr|F5GWB7|F5GWB7_HUMAN;tr|F5H709|F5H709_HUMAN","sp|P46087|NOP2_HUMAN;tr|A0A087WV73|A0A087WV73_HUMAN",1022,"P46087","NOP2_HUMAN","Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase",null,"NOP2"]
["17.7713","17.5016","18.0619","17.2284",{"$nulls":3},"glutathione biosynthetic process","glutamate-cysteine ligase activity",{"$nulls":4},1,1,1,"7.1","7.1","7.1","28.751",0,"14.253",23574000,9,"0.00615513","0.988366","-0.00871754","-0.0199038","tr|A0A0C4DGB2|A0A0C4DGB2_HUMAN;tr|E1CEI4|E1CEI4_HUMAN;sp|P48506|GSH1_HUMAN","tr|A0A0C4DGB2|A0A0C4DGB2_HUMAN;tr|E1CEI4|E1CEI4_HUMAN;sp|P48506|GSH1_HUMAN",1053,"A0A0C4DGB2","A0A0C4DGB2_HUMAN",null,null,"GCLC"]
["19.2475","18.8883","19.1707","18.9838",{"$nulls":3},"positive regulation of cell growth",null,"nucleus",{"$nulls":3},4,3,3,"7.5","6.3","6.3","74.316",0,"8.1129",175170000,6,"0.0144906","0.979693","-0.00939941","-0.0464328","sp|Q7Z4V5|HDGR2_HUMAN;tr|A0A087WZ99|A0A087WZ99_HUMAN;tr|A0A087WX58|A0A087WX58_HUMAN;tr|K7EPS6|K7EPS6_HUMAN","sp|Q7Z4V5|HDGR2_HUMAN;tr|A0A087WZ99|A0A087WZ99_HUMAN",1957,"Q7Z4V5","HDGR2_HUMAN","Hepatoma-derived growth factor-related protein 2","RP-2","HDGFL2"]
["20.9092","20.7645","21.1326","20.5668",{"$nulls":3},"alpha-linolenic acid metabolic process;bile acid biosynthetic process;fatty acid beta-oxidation using acyl-CoA oxidase;inositol trisphosphate biosynthetic process;lipid hydroperoxide transport;peroxisome organization;phospholipid transport;positive regulation of intracellular cholesterol transport;positive regulation of steroid metabolic process;progesterone biosynthetic process;protein localization to plasma membrane;steroid biosynthetic process","cholesterol binding;fatty-acyl-CoA binding;long-chain fatty acyl-CoA binding;oleic acid binding;phosphatidylinositol transporter activity;propanoyl-CoA C-acyltransferase activity;propionyl-CoA C2-trimethyltridecanoyltransferase activity;receptor binding;sterol transporter activity","extracellular exosome;intracellular membrane-bounded organelle;membrane;mitochondrion;nucleoplasm;peroxisomal matrix;peroxisome;protein complex","Biosynthesis of unsaturated fatty acids;Fatty acid metabolism;Metabolic pathways;Peroxisome;PPAR signaling pathway;Primary bile acid biosynthesis",null,null,3,3,3,"6.2","6.2","6.2","58.993",0,"12.434",428780000,17,"0.0137289","0.980305","-0.0128555","-0.0440281","sp|P22307|NLTP_HUMAN;tr|H0YF61|H0YF61_HUMAN","sp|P22307|NLTP_HUMAN",764,"P22307","NLTP_HUMAN","Non-specific lipid-transfer protein","SL-TP","SCP2"]
["19.8293","19.6533","19.9333","19.5755",{"$nulls":3},"negative regulation of axonogenesis;negative regulation of protein targeting to membrane;positive regulation of axon extension;protein transport;Rab protein signal transduction;regulation of small GTPase mediated signal transduction;response to calcium ion;signal transduction","GDP-dissociation inhibitor activity;GTPase activator activity;Rab GDP-dissociation inhibitor activity;Rab GTPase binding","axon;cytoplasm;cytosol;Golgi apparatus;midbody;myelin sheath;neuronal cell body;protein complex",{"$nulls":3},12,7,7,"41.6","27.1","27.1","50.582",0,"29.853",212830000,37,"0.0206716","0.974807","-0.0131197","-0.0658082","sp|P31150|GDIA_HUMAN;tr|G5E9U5|G5E9U5_HUMAN","sp|P31150|GDIA_HUMAN",883,"P31150","GDIA_HUMAN","Rab GDP dissociation inhibitor alpha","ab GDI alpha","GDI1"]
["21.0417","20.6067","21.1194","20.5555",{"$nulls":3},"cell differentiation;cellular iron ion homeostasis;negative regulation of catalytic activity;neutrophil degranulation;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;post-translational protein modification;protein ubiquitination;SCF complex assembly","TBP-class protein binding","cullin-RING ubiquitin ligase complex;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;Golgi apparatus;membrane;nucleoplasm;nucleus;secretory granule lumen;ubiquitin ligase complex",{"$nulls":3},19,19,19,"21.3","21.3","21.3","136.37",0,"138.46",1095100000,55,"0.0116211","0.982337","-0.0133009","-0.0373535","sp|Q86VP6|CAND1_HUMAN;tr|A0A0C4DGH5|A0A0C4DGH5_HUMAN;tr|H0YH27|H0YH27_HUMAN","sp|Q86VP6|CAND1_HUMAN;tr|A0A0C4DGH5|A0A0C4DGH5_HUMAN",1989,"Q86VP6","CAND1_HUMAN","Cullin-associated NEDD8-dissociated protein 1",null,"CAND1"]
["19.0471","18.8888","19.4396","18.5256",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport","zinc ion binding","COPII vesicle coat",{"$nulls":3},4,4,4,"5.3","5.3","5.3","111.98",0,"25.963",192970000,18,"0.00980389","0.983769","-0.0146446","-0.0315751","tr|G5EA31|G5EA31_HUMAN;sp|P53992|SC24C_HUMAN","tr|G5EA31|G5EA31_HUMAN;sp|P53992|SC24C_HUMAN",1186,"G5EA31","G5EA31_HUMAN"]
["21.7196","21.6915","21.7037","21.7373",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,19,19,19,"13.631",0,"45.371",245580000,12,"0.247932","0.779382","-0.0149517","-0.683159","tr|F5GX39|F5GX39_HUMAN;tr|E7EQ72|E7EQ72_HUMAN;sp|Q15363|TMED2_HUMAN","tr|F5GX39|F5GX39_HUMAN;tr|E7EQ72|E7EQ72_HUMAN;sp|Q15363|TMED2_HUMAN",1693,"F5GX39","F5GX39_HUMAN",null,null,"TMED2"]
["20.012","18.9537","19.9066","19.0934",{"$nulls":3},"cellular protein modification process;selenocysteine biosynthetic process","ATP binding;GTP binding;identical protein binding;protein heterodimerization activity;protein homodimerization activity;selenide, water dikinase activity","cytoplasm;nuclear membrane;plasma membrane","Metabolic pathways;Selenocompound metabolism",null,null,4,4,4,"16.3","16.3","16.3","42.91",0,"9.937",102460000,15,"0.00799423","0.983713","-0.0172157","-0.0257982","sp|P49903|SPS1_HUMAN;tr|Q5T5U6|Q5T5U6_HUMAN","sp|P49903|SPS1_HUMAN;tr|Q5T5U6|Q5T5U6_HUMAN",1104,"P49903","SPS1_HUMAN","Selenide, water dikinase 1",null,"SEPHS1"]
["19.5955","19.5087","19.6381","19.5022",{"$nulls":3},"adult locomotory behavior;aging;axonogenesis;chemical synaptic transmission;cyclic nucleotide catabolic process;forebrain development;microtubule cytoskeleton organization;oligodendrocyte differentiation;regulation of mitochondrial membrane permeability;response to lipopolysaccharide;response to toxic substance;substantia nigra development","2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;cyclic nucleotide binding;RNA binding","cytoplasm;extracellular exosome;extracellular space;melanosome;membrane;microtubule;microvillus;mitochondrial inner membrane;mitochondrial outer membrane;myelin sheath abaxonal region;myelin sheath adaxonal region;perinuclear region of cytoplasm;plasma membrane;pseudopodium",{"$nulls":3},6,6,6,"15.7","15.7","15.7","47.578",0,"40.836",212430000,20,"0.073849","0.930878","-0.0180521","-0.223898","sp|P09543|CN37_HUMAN;tr|K7ERC4|K7ERC4_HUMAN","sp|P09543|CN37_HUMAN",588,"P09543","CN37_HUMAN","2',3'-cyclic-nucleotide 3'-phosphodiesterase","NP;NPase","CNP"]
["17.355","17.984","17.9812","17.3982",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein ubiquitination;osteoblast differentiation;positive regulation of cell proliferation;positive regulation of glial cell proliferation;protein K69-linked ufmylation;protein ufmylation;regulation of intracellular estrogen receptor signaling pathway;regulation of proteasomal ubiquitin-dependent protein catabolic process;regulation of protein localization;response to endoplasmic reticulum stress;response to L-glutamate","ligase activity;UFM1 transferase activity","cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;membrane;neuron projection;protein complex",{"$nulls":3},6,6,6,"9.4","9.4","9.4","89.594",0,"19.542",121310000,22,"0.0146919","0.97971","-0.0201836","-0.0470676","sp|O94874|UFL1_HUMAN","sp|O94874|UFL1_HUMAN",395,"O94874","UFL1_HUMAN","E3 UFM1-protein ligase 1 {ECO:0000305}",null,"UFL1"]
["17.993","17.7396","19.0015","16.7734",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;basement membrane organization;cell migration involved in gastrulation;cell-cell adhesion involved in gastrulation;G-protein coupled receptor signaling pathway;in utero embryonic development;vasculature development;visual learning","G-protein alpha-subunit binding;GTPase activator activity;guanyl-nucleotide exchange factor activity","cytoplasm;plasma membrane",{"$nulls":3},4,4,4,"12.8","12.8","12.8","59.709",0,"16.834",88908000,10,"0.00583209","0.988081","-0.0211535","-0.018866","sp|Q9NPQ8|RIC8A_HUMAN;tr|E9PI04|E9PI04_HUMAN;tr|E9PLE5|E9PLE5_HUMAN;tr|H0YE35|H0YE35_HUMAN;tr|H0YC88|H0YC88_HUMAN;tr|E9PSI0|E9PSI0_HUMAN","sp|Q9NPQ8|RIC8A_HUMAN;tr|E9PI04|E9PI04_HUMAN",2664,"Q9NPQ8","RIC8A_HUMAN","Synembryn-A",null,"RIC8A"]
["18.5616","18.4412","18.3619","18.6835",{"$nulls":3},"clathrin-dependent endocytosis;intracellular protein transport;membrane organization","clathrin heavy chain binding;peptide binding;structural molecule activity","ciliary membrane;clathrin coat;clathrin coat of coated pit;clathrin coat of trans-Golgi network vesicle;clathrin vesicle coat;clathrin-coated endocytic vesicle;cytosol;intracellular membrane-bounded organelle;plasma membrane;trans-Golgi network","Bacterial invasion of epithelial cells;Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Huntington disease;Lysosome;Synaptic vesicle cycle",null,null,1,1,1,"4.4","4.4","4.4","25.19","0.0011119","2.7312",27538000,5,"0.0397604","0.956837","-0.0213242","-0.1242","sp|P09497|CLCB_HUMAN","sp|P09497|CLCB_HUMAN",586,"P09497","CLCB_HUMAN","Clathrin light chain B","cb","CLTB"]
["19.6735","19.4501","19.8095","19.3576",{"$nulls":3},"acetate biosynthetic process;acetyl-CoA biosynthetic process from acetate;ethanol oxidation;lipid biosynthetic process;mitochondrion organization;propionate biosynthetic process","acetate-CoA ligase activity;AMP binding;ATP binding","cytoplasm;cytosol;intracellular membrane-bounded organelle;mitochondrial matrix;nucleoplasm","Carbon metabolism;Glycolysis / Gluconeogenesis;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism",null,null,4,4,4,"9.8","9.8","9.8","78.579",0,"10.75",189800000,24,"0.0272772","0.966777","-0.0217371","-0.086252","sp|Q9NR19|ACSA_HUMAN","sp|Q9NR19|ACSA_HUMAN",2677,"Q9NR19","ACSA_HUMAN","Acetyl-coenzyme A synthetase, cytoplasmic",null,"ACSS2"]
["17.6832","17.3575","17.6203","17.4646",{"$nulls":3},"L-serine biosynthetic process","phosphoserine phosphatase activity",{"$nulls":4},1,1,1,"11.8","11.8","11.8","20.745",0,"14.87",21743000,9,"0.0392228","0.956932","-0.0221272","-0.122583","tr|C9JBI3|C9JBI3_HUMAN;sp|P78330|SERB_HUMAN","tr|C9JBI3|C9JBI3_HUMAN;sp|P78330|SERB_HUMAN",1365,"C9JBI3","C9JBI3_HUMAN",null,null,"PSPH"]
["14.3581","15.6302","16.2827","13.7518",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process;apoptotic signaling pathway;cell differentiation;clathrin coat assembly;clathrin-dependent endocytosis;membrane organization;neurotransmitter receptor transport;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of platelet-derived growth factor receptor-beta signaling pathway;positive regulation of protein kinase B signaling;positive regulation of receptor-mediated endocytosis;protein stabilization;regulation of apoptotic process;regulation of endocytosis;regulation of transcription, DNA-templated;transcription, DNA-templated","actin filament binding;AP-2 adaptor complex binding;clathrin adaptor activity;clathrin binding;clathrin light chain binding;epidermal growth factor receptor binding;glutamate receptor binding;phosphatidylinositol binding;phosphatidylinositol-3,4-bisphosphate binding;phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-3-phosphate binding;protein heterodimerization activity;protein homodimerization activity;structural constituent of cytoskeleton","clathrin-coated vesicle;clathrin-coated vesicle membrane;cytoplasm;cytoskeleton;cytosol;extrinsic component of cytoplasmic side of plasma membrane;extrinsic component of postsynaptic membrane;extrinsic component of presynaptic membrane;Golgi apparatus;intracellular membrane-bounded organelle;membrane;nucleus;postsynapse;presynapse","Huntington disease",null,null,2,2,2,"4.3","4.3","4.3","116.22",0,"4.3998",16131000,7,"0.00502277","0.990561","-0.0230331","-0.0162627","sp|O00291|HIP1_HUMAN","sp|O00291|HIP1_HUMAN",133,"O00291","HIP1_HUMAN","Huntingtin-interacting protein 1","IP-1","HIP1"]
["20.1559","20.712","20.9583","19.9572",{"$nulls":3},"proline biosynthetic process","pyrroline-5-carboxylate reductase activity",{"$nulls":4},3,3,3,"17.7","17.7","17.7","30.213",0,"16.676",189040000,23,"0.0129381","0.980461","-0.0237799","-0.0415275","tr|E2QRB3|E2QRB3_HUMAN;sp|P32322|P5CR1_HUMAN;tr|J3QR88|J3QR88_HUMAN;tr|J3QLK9|J3QLK9_HUMAN;tr|J3QL23|J3QL23_HUMAN;tr|J3QL32|J3QL32_HUMAN;tr|J3QL24|J3QL24_HUMAN;tr|J3QKT4|J3QKT4_HUMAN;tr|J3KQ22|J3KQ22_HUMAN","tr|E2QRB3|E2QRB3_HUMAN;sp|P32322|P5CR1_HUMAN",904,"E2QRB3","E2QRB3_HUMAN"]
["17.7295","17.9892","18.6038","17.1671",{"$nulls":9},1,1,1,"12.3","12.3","12.3","21.491","0.0053655","1.8993",12425000,5,"0.0111244","0.98318","-0.0261154","-0.0357762","tr|H7C3D5|H7C3D5_HUMAN;sp|Q8NC44|F134A_HUMAN","tr|H7C3D5|H7C3D5_HUMAN;sp|Q8NC44|F134A_HUMAN",2078,"H7C3D5","H7C3D5_HUMAN",null,null,"RETREG2"]
["19.7514","19.4522","19.8335","19.4228",{"$nulls":3},"aerobic respiration;mitochondrial calcium ion transmembrane transport;mitochondrial electron transport, ubiquinol to cytochrome c;protein processing","metalloendopeptidase activity;zinc ion binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrial respiratory chain complex III;mitochondrion",{"$nulls":3},6,5,5,"19.4",18,18,"54.366",0,"24.981",160850000,19,"0.0330051","0.963304","-0.0263643","-0.103772","sp|O75439|MPPB_HUMAN;tr|G3V0E4|G3V0E4_HUMAN;tr|F8WAZ6|F8WAZ6_HUMAN;tr|F8WEA6|F8WEA6_HUMAN;tr|F8WBE1|F8WBE1_HUMAN","sp|O75439|MPPB_HUMAN;tr|G3V0E4|G3V0E4_HUMAN",345,"O75439","MPPB_HUMAN","Mitochondrial-processing peptidase subunit beta",null,"PMPCB"]
["21.5057","21.3413","21.5854","21.3171",{"$nulls":3},"alternative mRNA splicing, via spliceosome;androgen receptor signaling pathway;defense response to virus;epithelial to mesenchymal transition;gene silencing by RNA;intracellular estrogen receptor signaling pathway;miRNA metabolic process;myoblast differentiation;positive regulation of transcription from RNA polymerase II promoter;regulation of alternative mRNA splicing, via spliceosome;regulation of skeletal muscle cell differentiation;regulation of transcription from RNA polymerase II promoter;RNA processing;RNA secondary structure unwinding;rRNA processing;transcription, DNA-templated","ATP binding;ATP-dependent RNA helicase activity;RNA binding;RNA helicase activity;RNA-dependent ATPase activity;transcription coactivator activity","cytoplasm;cytosol;membrane;nuclear speck;nucleolus;nucleoplasm;nucleus",{"$nulls":3},10,10,7,"19.9","19.9","15.9","80.272",0,"33.313",845930000,54,"0.0573202","0.944754","-0.0277205","-0.176213","sp|Q92841|DDX17_HUMAN;tr|H3BLZ8|H3BLZ8_HUMAN","sp|Q92841|DDX17_HUMAN;tr|H3BLZ8|H3BLZ8_HUMAN",2196,"Q92841","DDX17_HUMAN","Probable ATP-dependent RNA helicase DDX17",null,"DDX17"]
["18.3702","17.743","18.8955","17.2759",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;adenylate cyclase-modulating G-protein coupled receptor signaling pathway;cell cycle;cell division;cellular response to forskolin;G-protein coupled receptor signaling pathway;negative regulation of synaptic transmission;positive regulation of protein localization to cell cortex;protein folding;regulation of cAMP-mediated signaling;regulation of mitotic spindle organization;response to peptide hormone","GDP binding;G-protein beta/gamma-subunit complex binding;G-protein coupled receptor binding;G-protein coupled serotonin receptor binding;GTP binding;GTPase activating protein binding;GTPase activity;magnesium ion binding;signal transducer activity","cell cortex region;centrosome;cytoplasm;extracellular exosome;heterotrimeric G-protein complex;lysosomal membrane;membrane raft;midbody;nucleolus;nucleus;plasma membrane","Adrenergic signaling in cardiomyocytes;Alcoholism;Apelin signaling pathway;Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Leukocyte transendothelial migration;Long-term depression;Melanogenesis;Morphine addiction;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Serotonergic synapse;Sphingolipid signaling pathway;Toxoplasmosis",null,null,3,2,2,11,"7.9","7.9","40.361","0.0007657","2.9797",43082000,3,"0.010393","0.983021","-0.0290489","-0.033451","sp|P63096|GNAI1_HUMAN;tr|C9JPP4|C9JPP4_HUMAN;tr|C9JL77|C9JL77_HUMAN","sp|P63096|GNAI1_HUMAN;tr|C9JPP4|C9JPP4_HUMAN",1340,"P63096","GNAI1_HUMAN","Guanine nucleotide-binding protein G(i) subunit alpha-1",null,"GNAI1"]
["19.1204","19.0454","19.55","18.6745",{"$nulls":9},1,1,1,"22.4","22.4","22.4","7.0871","0.0010749","2.4125",19828000,2,"0.0210065","0.975158","-0.0293703","-0.0668512","tr|F5H7P1|F5H7P1_HUMAN;tr|Q9BTR4|Q9BTR4_HUMAN;tr|F5H6P8|F5H6P8_HUMAN;tr|H0YG37|H0YG37_HUMAN;tr|F5H784|F5H784_HUMAN;tr|H0YGR4|H0YGR4_HUMAN;tr|F5GYG5|F5GYG5_HUMAN;sp|Q9Y3B8|ORN_HUMAN","tr|F5H7P1|F5H7P1_HUMAN;tr|Q9BTR4|Q9BTR4_HUMAN;tr|F5H6P8|F5H6P8_HUMAN;tr|H0YG37|H0YG37_HUMAN;tr|F5H784|F5H784_HUMAN;tr|H0YGR4|H0YGR4_HUMAN;tr|F5GYG5|F5GYG5_HUMAN;sp|Q9Y3B8|ORN_HUMAN",2981,"F5H7P1","F5H7P1_HUMAN",null,null,"REXO2"]
["22.238","21.981","22.434","21.8445",{"$nulls":3},"autophagosome assembly;Golgi organization;membrane fusion;nuclear envelope reassembly;proteasome-mediated ubiquitin-dependent protein catabolic process","ATPase binding;phospholipid binding;protein phosphatase regulator activity;ubiquitin binding","chromosome;cytosol;Golgi stack;intermediate filament cytoskeleton;nucleoplasm;nucleus;plasma membrane;VCP-NSFL1C complex","Protein processing in endoplasmic reticulum",null,null,8,8,8,33,33,33,"40.572",0,"90.639",1028900000,50,"0.0293284","0.967043","-0.0297546","-0.0925476","sp|Q9UNZ2|NSF1C_HUMAN;tr|F2Z2K0|F2Z2K0_HUMAN;tr|R4GNE6|R4GNE6_HUMAN","sp|Q9UNZ2|NSF1C_HUMAN;tr|F2Z2K0|F2Z2K0_HUMAN",2918,"Q9UNZ2","NSF1C_HUMAN","NSFL1 cofactor p47",null,"NSFL1C"]
["23.8359","23.6935","24.3511","23.238",{"$nulls":3},"apoptotic process;blood coagulation, intrinsic pathway;complement activation, classical pathway;immune response;innate immune response;mature ribosome assembly;mRNA processing;negative regulation of defense response to virus;negative regulation of interferon-gamma production;negative regulation of interleukin-12 production;negative regulation of MDA-5 signaling pathway;negative regulation of mRNA splicing, via spliceosome;negative regulation of RIG-I signaling pathway;negative regulation of transcription from RNA polymerase II promoter;phosphatidylinositol 3-kinase signaling;positive regulation of apoptotic process;positive regulation of cell adhesion;positive regulation of dendritic cell chemotaxis;positive regulation of mitochondrial translation;positive regulation of neutrophil chemotaxis;positive regulation of protein kinase B signaling;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of trophoblast cell migration;regulation of complement activation;RNA splicing;transcription, DNA-templated;viral process","adrenergic receptor binding;complement component C1q binding;hyaluronic acid binding;kininogen binding;mitochondrial ribosome binding;mRNA binding;protein kinase C binding;transcription corepressor activity;transcription factor binding","cell surface;cytoplasm;cytosol;extracellular space;membrane;mitochondrial matrix;mitochondrion;nucleolus;nucleus;plasma membrane",{"$nulls":3},6,6,6,"40.8","40.8","40.8","31.362",0,"168.66",1536300000,78,"0.0166581","0.977298","-0.0298805","-0.053255","sp|Q07021|C1QBP_HUMAN;tr|I3L3Q7|I3L3Q7_HUMAN;tr|I3L3B0|I3L3B0_HUMAN","sp|Q07021|C1QBP_HUMAN;tr|I3L3Q7|I3L3Q7_HUMAN;tr|I3L3B0|I3L3B0_HUMAN",1463,"Q07021","C1QBP_HUMAN","Complement component 1 Q subcomponent-binding protein, mitochondrial",null,"C1QBP"]
["20.32","20.0667","19.7793","20.6684",{"$nulls":3},"signal transduction","GTP binding;GTPase activity","membrane",{"$nulls":3},4,4,4,"53.2","53.2","53.2","8.6739",0,"8.1953",103290000,11,"0.0206948","0.975307","-0.0304537","-0.0658805","tr|C9J931|C9J931_HUMAN;sp|Q15382|RHEB_HUMAN;tr|C9J469|C9J469_HUMAN","tr|C9J931|C9J931_HUMAN;sp|Q15382|RHEB_HUMAN",1697,"C9J931","C9J931_HUMAN",null,null,"RHEB"]
["20.8477","21.1549","21.0756","20.9893",{"$nulls":3},"cell redox homeostasis","isomerase activity","cell",{"$nulls":3},9,9,9,"38.6","38.6","38.6","40.369",0,"179.07",481670000,21,"0.0638584","0.937625","-0.0311365","-0.195213","tr|Q86UY0|Q86UY0_HUMAN;sp|Q8NBS9|TXND5_HUMAN","tr|Q86UY0|Q86UY0_HUMAN;sp|Q8NBS9|TXND5_HUMAN",2077,"Q86UY0","Q86UY0_HUMAN",null,null,"TXNDC5"]
["20.5951","20.4306","21.2842","19.805",{"$nulls":5},"nuclear membrane;nucleoplasm",{"$nulls":3},3,3,3,"22.2","22.2","22.2","24.465",0,"18.369",169540000,10,"0.0132855","0.980607","-0.0317211","-0.0426265","tr|C9JRH2|C9JRH2_HUMAN;tr|C9JMJ4|C9JMJ4_HUMAN;tr|C9J3R0|C9J3R0_HUMAN;tr|C9JQZ4|C9JQZ4_HUMAN;tr|C9JW69|C9JW69_HUMAN;sp|P18754|RCC1_HUMAN","tr|C9JRH2|C9JRH2_HUMAN;tr|C9JMJ4|C9JMJ4_HUMAN;tr|C9J3R0|C9J3R0_HUMAN;tr|C9JQZ4|C9JQZ4_HUMAN;tr|C9JW69|C9JW69_HUMAN;sp|P18754|RCC1_HUMAN",724,"C9JRH2","C9JRH2_HUMAN",null,null,"RCC1"]
["20.2747","19.8831","20.2766","19.9458",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;cell migration","actin filament binding","Arp2/3 protein complex;cytoplasm;extracellular exosome;focal adhesion","Bacterial invasion of epithelial cells;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,4,4,4,"41.2","41.2","41.2","16.941",0,"6.0321",122340000,14,"0.0403841","0.956392","-0.0323162","-0.126074","sp|Q9BPX5|ARP5L_HUMAN","sp|Q9BPX5|ARP5L_HUMAN",2408,"Q9BPX5","ARP5L_HUMAN","Actin-related protein 2/3 complex subunit 5-like protein",null,"ARPC5L"]
["19.6115","19.6222","19.8913","19.4079",{"$nulls":3},"intracellular transport",null,"nucleoplasm",{"$nulls":3},6,6,6,"15.6","15.6","15.6","52.894",0,"20.227",153140000,24,"0.0435313","0.954591","-0.0327549","-0.135498","tr|B7Z7F3|B7Z7F3_HUMAN;sp|Q9H6Z4|RANB3_HUMAN;tr|K7ESQ0|K7ESQ0_HUMAN;tr|K7EIJ4|K7EIJ4_HUMAN","tr|B7Z7F3|B7Z7F3_HUMAN;sp|Q9H6Z4|RANB3_HUMAN;tr|K7ESQ0|K7ESQ0_HUMAN;tr|K7EIJ4|K7EIJ4_HUMAN",2608,"B7Z7F3","B7Z7F3_HUMAN",null,null,"RANBP3"]
["20.5956","20.2185","20.7477","20.1325",{"$nulls":3},"cellular protein localization;double-strand break repair via nonhomologous end joining;generation of catalytic spliceosome for first transesterification step;inner cell mass cell proliferation;lipid biosynthetic process;mRNA splicing, via spliceosome;negative regulation of neuron differentiation;positive regulation of astrocyte differentiation;positive regulation of mRNA splicing, via spliceosome;proteasomal protein catabolic process;protein K63-linked ubiquitination;protein polyubiquitination;signal transduction involved in DNA damage checkpoint;spliceosomal complex assembly;spliceosomal tri-snRNP complex assembly;transcription-coupled nucleotide-excision repair","identical protein binding;ubiquitin protein ligase activity;ubiquitin-ubiquitin ligase activity","catalytic step 2 spliceosome;cytoplasm;lipid droplet;membrane;nuclear speck;nucleoplasm;nucleus;Prp19 complex;site of double-strand break;spindle;U2-type catalytic step 1 spliceosome","Spliceosome;Ubiquitin mediated proteolysis",null,null,7,7,7,"27.2","27.2","27.2","55.18",0,"93.05",256050000,37,"0.0290264","0.966839","-0.0330601","-0.0916224","sp|Q9UMS4|PRP19_HUMAN;tr|F5GY56|F5GY56_HUMAN;tr|F5H2I0|F5H2I0_HUMAN;tr|H0YGF3|H0YGF3_HUMAN","sp|Q9UMS4|PRP19_HUMAN;tr|F5GY56|F5GY56_HUMAN",2902,"Q9UMS4","PRP19_HUMAN","Pre-mRNA-processing factor 19 {ECO:0000305}",null,"PRPF19"]
["22.2862","21.8858","22.2905","21.9495",{"$nulls":3},"cardiac muscle cell development;cell cycle;cell division;cellular response to glucocorticoid stimulus;cellular response to leukemia inhibitory factor;circadian regulation of gene expression;covalent chromatin modification;CRD-mediated mRNA stabilization;dosage compensation by inactivation of X chromosome;maintenance of protein location in nucleus;mRNA splicing, via spliceosome;mRNA stabilization;negative regulation of kinase activity;negative regulation of stem cell differentiation;negative regulation of telomere maintenance via telomerase;negative regulation of transcription elongation from RNA polymerase II promoter;negative regulation of transcription from RNA polymerase II promoter;osteoblast differentiation;positive regulation of attachment of mitotic spindle microtubules to kinetochore;positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;positive regulation of stem cell proliferation;positive regulation of transcription from RNA polymerase II promoter;protein localization to spindle microtubule;regulation of alternative mRNA splicing, via spliceosome;regulation of chromatin organization;regulation of mitotic cell cycle;regulation of mitotic spindle assembly;RNA localization to chromatin;RNA metabolic process;RNA processing;transcription, DNA-templated","actin binding;ATP binding;chromatin binding;chromatin DNA binding;core promoter binding;DNA binding;double-stranded DNA binding;double-stranded RNA binding;identical protein binding;macromolecular complex binding;mRNA 3'-UTR binding;poly(A) binding;poly(C) RNA binding;poly(G) binding;pre-mRNA binding;promoter-specific chromatin binding;ribonucleoprotein complex binding;RNA binding;RNA polymerase II core binding;RNA polymerase II C-terminal domain binding;sequence-specific double-stranded DNA binding;single-stranded DNA binding;single-stranded RNA binding;snRNA binding;telomerase RNA binding;TFIIH-class transcription factor binding;transcription corepressor activity","catalytic step 2 spliceosome;cell surface;centrosome;condensed chromosome kinetochore;CRD-mediated mRNA stability complex;cytoplasmic ribonucleoprotein granule;extracellular matrix;inactive sex chromosome;intracellular ribonucleoprotein complex;kinetochore;macromolecular complex;membrane;midbody;mitotic spindle;mitotic spindle microtubule;mitotic spindle midzone;nuclear chromosome;nuclear matrix;nuclear speck;nucleoplasm;nucleus;ribonucleoprotein complex;spindle pole","Spliceosome",null,null,12,12,12,"18.1","18.1","18.1","90.583",0,"118.55",1449700000,80,"0.0414394","0.954676","-0.0339832","-0.129239","sp|Q00839|HNRPU_HUMAN;tr|Q5RI18|Q5RI18_HUMAN","sp|Q00839|HNRPU_HUMAN",1411,"Q00839","HNRPU_HUMAN","Heterogeneous nuclear ribonucleoprotein U {ECO:0000303|PubMed:1628625}","nRNP U {ECO:0000303|PubMed:1628625}","HNRNPU"]
["22.7845","22.4156","23.1817","22.0868",{"$nulls":3},"ubiquitin-dependent protein catabolic process","threonine-type endopeptidase activity","cytoplasm;nucleus;proteasome core complex, alpha-subunit complex","Proteasome",null,null,6,6,6,"37.6","37.6","37.6","25.898",0,"85.615",787560000,45,"0.0185661","0.975192","-0.0342197","-0.0592356","tr|A0A024RA52|A0A024RA52_HUMAN;sp|P25787|PSA2_HUMAN;tr|H3BT36|H3BT36_HUMAN;tr|H7C402|H7C402_HUMAN;tr|C9JCK5|C9JCK5_HUMAN","tr|A0A024RA52|A0A024RA52_HUMAN;sp|P25787|PSA2_HUMAN",802,"A0A024RA52","A0A024RA52_HUMAN","Proteasome subunit alpha type {ECO:0000256|RuleBase:RU000551}"]
["21.3488","21.2557","21.0741","21.5996",{"$nulls":5},"MICOS complex",{"$nulls":3},2,2,2,"17.1","17.1","17.1","15.303",0,"9.066",173570000,17,"0.0415932","0.95466","-0.0346107","-0.1297","tr|J3QTB2|J3QTB2_HUMAN;sp|Q9BRQ6|MIC25_HUMAN;tr|J3QTA6|J3QTA6_HUMAN;tr|H0Y922|H0Y922_HUMAN","tr|J3QTB2|J3QTB2_HUMAN;sp|Q9BRQ6|MIC25_HUMAN;tr|J3QTA6|J3QTA6_HUMAN;tr|H0Y922|H0Y922_HUMAN",2429,"J3QTB2","J3QTB2_HUMAN","MICOS complex subunit {ECO:0000256|RuleBase:RU363001}",null,"CHCHD6"]
["19.4222","19.1762","19.5649","19.1045",{"$nulls":3},"negative regulation of epithelial cell proliferation involved in prostate gland development;positive regulation of cell proliferation;regulation of transcription from RNA polymerase II promoter;secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;spliceosomal snRNP assembly","ligand-dependent nuclear receptor transcription coactivator activity;methyl-CpG binding;protein-arginine N-methyltransferase activity","cytoplasm;cytosol;Golgi apparatus;methylosome;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"14.6","14.6","14.6","36.724",0,"3.7362",63904000,15,"0.0436702","0.954774","-0.0354748","-0.135913","sp|Q9BQA1|MEP50_HUMAN;tr|H0Y711|H0Y711_HUMAN","sp|Q9BQA1|MEP50_HUMAN;tr|H0Y711|H0Y711_HUMAN",2417,"Q9BQA1","MEP50_HUMAN","Methylosome protein 50","EP-50","WDR77"]
["18.2973","18.4845","19.0586","17.7953",{"$nulls":9},2,2,2,"21.5","21.5","21.5","17.217",0,"6.1735",38592000,5,"0.0176866","0.977143","-0.0360661","-0.0564816","tr|V9GYZ0|V9GYZ0_HUMAN;sp|Q9BZ23|PANK2_HUMAN;tr|E5RHA5|E5RHA5_HUMAN;sp|Q9H999|PANK3_HUMAN","tr|V9GYZ0|V9GYZ0_HUMAN;sp|Q9BZ23|PANK2_HUMAN;tr|E5RHA5|E5RHA5_HUMAN;sp|Q9H999|PANK3_HUMAN",2514,"V9GYZ0","V9GYZ0_HUMAN",null,null,"PANK2"]
["23.5644","23.4573","23.7038","23.3915",{"$nulls":3},"cell adhesion",null,"integral component of membrane",{"$nulls":3},4,4,4,"57.3","57.3","57.3","9.105",0,"36.344",525210000,25,"0.073533","0.930193","-0.036808","-0.222997","tr|H0YE40|H0YE40_HUMAN;tr|H0YD13|H0YD13_HUMAN;tr|H0Y2P0|H0Y2P0_HUMAN;sp|P16070|CD44_HUMAN;tr|J3KN83|J3KN83_HUMAN","tr|H0YE40|H0YE40_HUMAN;tr|H0YD13|H0YD13_HUMAN;tr|H0Y2P0|H0Y2P0_HUMAN;sp|P16070|CD44_HUMAN",692,"H0YE40","H0YE40_HUMAN",null,null,"CD44"]
["23.5049","23.081","23.2874","23.3729",{"$nulls":3},"negative regulation of RNA splicing;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA 5'-UTR binding;mRNA binding;RNA binding;small ribosomal subunit rRNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleolus;nucleoplasm;nucleus;ribosome","Ribosome",null,null,5,5,5,"29.8","29.8","29.8","17.222",0,"15.567",1214600000,24,"0.0559107","0.945584","-0.0372152","-0.172093","sp|P62277|RS13_HUMAN;tr|J3KMX5|J3KMX5_HUMAN;tr|E9PS50|E9PS50_HUMAN","sp|P62277|RS13_HUMAN;tr|J3KMX5|J3KMX5_HUMAN",1300,"P62277","RS13_HUMAN","40S ribosomal protein S13",null,"RPS13"]
["18.6","18.425","18.9438","18.1564",{"$nulls":3},"actin cytoskeleton organization;muscle organ development","actin binding;metal ion binding","focal adhesion;nucleus;stress fiber;Z disc",{"$nulls":3},1,1,1,"3.6","3.6","3.6","31.192",0,"3.5657",60926000,4,"0.0295073","0.967195","-0.0375443","-0.0930956","sp|Q13643|FHL3_HUMAN","sp|Q13643|FHL3_HUMAN",1583,"Q13643","FHL3_HUMAN","Four and a half LIM domains protein 3","HL-3","FHL3"]
["18.705","18.5508","19.4059","17.9299",{"$nulls":3},"proton-transporting ATP synthase complex assembly",null,"cytosol;mitochondrion;nuclear speck",{"$nulls":3},2,2,2,"7.3","7.3","7.3","32.772",0,"3.5048",66732000,5,"0.0168713","0.977634","-0.0400143","-0.0539246","sp|Q8N5M1|ATPF2_HUMAN;tr|K7ELC1|K7ELC1_HUMAN;tr|C9J2Q2|C9J2Q2_HUMAN","sp|Q8N5M1|ATPF2_HUMAN;tr|K7ELC1|K7ELC1_HUMAN;tr|C9J2Q2|C9J2Q2_HUMAN",2058,"Q8N5M1","ATPF2_HUMAN","ATP synthase mitochondrial F1 complex assembly factor 2",null,"ATPAF2"]
["18.7913","18.9007","19.1298","18.6421",{"$nulls":3},"DNA recombination;double-strand break repair","DNA binding","fibrillar center;nucleus",{"$nulls":3},2,2,2,"14.3","14.3","14.3","24.751",0,"5.1155",40593000,2,"0.0518526","0.948878","-0.0400305","-0.160177","tr|H7C0G7|H7C0G7_HUMAN;sp|Q9H9Q4|NHEJ1_HUMAN;tr|C9JWV4|C9JWV4_HUMAN;tr|G5E9Q8|G5E9Q8_HUMAN","tr|H7C0G7|H7C0G7_HUMAN;sp|Q9H9Q4|NHEJ1_HUMAN;tr|C9JWV4|C9JWV4_HUMAN;tr|G5E9Q8|G5E9Q8_HUMAN",2627,"H7C0G7","H7C0G7_HUMAN",null,null,"NHEJ1"]
["18.3929","18.2355","18.6765","18.0321",{"$nulls":3},"COPII-coated vesicle budding;intracellular protein transport","zinc ion binding","COPII vesicle coat;Golgi membrane",{"$nulls":3},4,4,4,"7.3","7.3","7.3","82.968",0,"57.417",116180000,14,"0.0386579","0.957279","-0.0400915","-0.120883","tr|F5H365|F5H365_HUMAN;sp|Q15436|SC23A_HUMAN","tr|F5H365|F5H365_HUMAN;sp|Q15436|SC23A_HUMAN",1704,"F5H365","F5H365_HUMAN",null,null,"SEC23A"]
["19.1661","19.0247","19.9797","18.2936",{"$nulls":3},"platelet degranulation;positive regulation of interferon-gamma production;positive regulation of memory T cell activation;positive regulation of T cell activation;positive regulation of T cell mediated cytotoxicity","MHC class Ib protein binding, via antigen binding groove","cilium;extracellular exosome;extracellular region;membrane;platelet alpha granule lumen",{"$nulls":3},2,2,2,"9.9","9.9","9.9","36.748",0,"7.4083",103470000,15,"0.0152152","0.980063","-0.041214","-0.048717","sp|Q9NUQ9|FA49B_HUMAN;tr|E5RK61|E5RK61_HUMAN;tr|E5RFS4|E5RFS4_HUMAN;tr|E5RHU5|E5RHU5_HUMAN;tr|E5RGI7|E5RGI7_HUMAN;tr|E5RJE1|E5RJE1_HUMAN;tr|E5RIR8|E5RIR8_HUMAN;tr|E5RJL8|E5RJL8_HUMAN;tr|E5RI16|E5RI16_HUMAN","sp|Q9NUQ9|FA49B_HUMAN;tr|E5RK61|E5RK61_HUMAN;tr|E5RFS4|E5RFS4_HUMAN;tr|E5RHU5|E5RHU5_HUMAN;tr|E5RGI7|E5RGI7_HUMAN;tr|E5RJE1|E5RJE1_HUMAN;tr|E5RIR8|E5RIR8_HUMAN;tr|E5RJL8|E5RJL8_HUMAN;tr|E5RI16|E5RI16_HUMAN",2710,"Q9NUQ9","FA49B_HUMAN","Protein FAM49B",null,"FAM49B"]
["20.2946","20.0047","20.3445","20.0375",{"$nulls":3},"adaptation of rhodopsin mediated signaling;retinal metabolic process;retinoid metabolic process;retinol metabolic process","NADP-retinol dehydrogenase activity;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;retinol dehydrogenase activity","endoplasmic reticulum membrane;integral component of membrane;intracellular;photoreceptor inner segment","Metabolic pathways;Retinol metabolism",null,null,4,4,3,"18.6","18.6","14.8","35.386",0,"9.103",231950000,17,"0.0641296","0.937601","-0.0413771","-0.195997","sp|Q8TC12|RDH11_HUMAN;tr|G3V2G6|G3V2G6_HUMAN;tr|H0YIZ8|H0YIZ8_HUMAN;tr|G3V234|G3V234_HUMAN;tr|H0YJ46|H0YJ46_HUMAN","sp|Q8TC12|RDH11_HUMAN;tr|G3V2G6|G3V2G6_HUMAN;tr|H0YIZ8|H0YIZ8_HUMAN;tr|G3V234|G3V234_HUMAN",2114,"Q8TC12","RDH11_HUMAN","Retinol dehydrogenase 11",null,"RDH11"]
["16.7731","17.7603","18.3927","16.2236",{"$nulls":3},"IRE1-mediated unfolded protein response;liver development;multicellular organism aging;nitrogen compound metabolic process;posttranslational protein targeting to endoplasmic reticulum membrane;posttranslational protein targeting to membrane, translocation;protein targeting to membrane;renal system development;SRP-dependent cotranslational protein targeting to membrane","protein transporter activity;receptor activity;RNA binding","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane","Protein export;Protein processing in endoplasmic reticulum",null,null,3,3,3,"6.7","6.7","6.7","87.996",0,"8.9814",81796000,10,"0.0108126","0.982508","-0.0414486","-0.0347853","sp|Q9UGP8|SEC63_HUMAN;tr|A6PVC9|A6PVC9_HUMAN","sp|Q9UGP8|SEC63_HUMAN;tr|A6PVC9|A6PVC9_HUMAN",2823,"Q9UGP8","SEC63_HUMAN","Translocation protein SEC63 homolog",null,"SEC63"]
["19.7455","19.5891","20.0469","19.3735",{"$nulls":3},"protein neddylation","acid-amino acid ligase activity;ATP binding;NEDD8 activating enzyme activity",{"$nulls":4},4,4,4,"14.7","14.7","14.7","47.271",0,"11.232",122780000,12,"0.0397402","0.956488","-0.0429087","-0.124139","tr|F8W8D4|F8W8D4_HUMAN;sp|Q8TBC4|UBA3_HUMAN","tr|F8W8D4|F8W8D4_HUMAN;sp|Q8TBC4|UBA3_HUMAN",2113,"F8W8D4","F8W8D4_HUMAN",null,null,"UBA3"]
["22.8344","22.6714","23.038","22.5538",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of endopeptidase activity;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex;synapse","Proteasome",null,null,5,5,5,"23.1","23.1","23.1","28.433",0,"17.834",1061100000,15,"0.0546267","0.946215","-0.0429983","-0.168331","sp|P25788|PSA3_HUMAN;tr|G3V3W4|G3V3W4_HUMAN;tr|G3V5N4|G3V5N4_HUMAN;tr|G3V4X5|G3V4X5_HUMAN","sp|P25788|PSA3_HUMAN",803,"P25788","PSA3_HUMAN","Proteasome subunit alpha type-3",null,"PSMA3"]
["18.0893","18.144","18.2297","18.0909",{"$nulls":3},"rRNA base methylation","rRNA (cytosine-N4-)-methyltransferase activity",{"$nulls":4},3,3,3,"10.8","10.8","10.8","46.121",0,"17.392",52661000,13,"0.209337","0.81454","-0.0436573","-0.585392","sp|A6NJ78|MET15_HUMAN;tr|B5MC64|B5MC64_HUMAN;tr|F8WD83|F8WD83_HUMAN","sp|A6NJ78|MET15_HUMAN",107,"A6NJ78","MET15_HUMAN","Probable methyltransferase-like protein 15",null,"METTL15"]
["19.0561","18.94","19.0021","19.0849",{"$nulls":4},"phosphoprotein phosphatase activity",{"$nulls":4},4,4,4,"14.8","14.8","14.8","55.096",0,"68.825",144840000,28,"0.229775","0.794174","-0.0454493","-0.637304","tr|H0YDU8|H0YDU8_HUMAN;sp|P53041|PPP5_HUMAN;tr|A8MU39|A8MU39_HUMAN","tr|H0YDU8|H0YDU8_HUMAN;sp|P53041|PPP5_HUMAN;tr|A8MU39|A8MU39_HUMAN",1175,"H0YDU8","H0YDU8_HUMAN","Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273}",null,"PPP5C"]
["22.3797","22.0468","22.7367","21.7812",{"$nulls":3},"acetyl-CoA biosynthetic process;acetyl-CoA catabolic process;adipose tissue development;brain development;branched-chain amino acid catabolic process;coenzyme A biosynthetic process;coenzyme A metabolic process;fatty acid beta-oxidation;isoleucine catabolic process;ketone body biosynthetic process;ketone body catabolic process;ketone body metabolic process;liver development;metanephric proximal convoluted tubule development;propionyl-CoA biosynthetic process;protein homooligomerization;response to hormone;response to organic cyclic compound;response to starvation","acetyl-CoA C-acetyltransferase activity;carbon-carbon lyase activity;coenzyme binding;enzyme binding;ligase activity, forming carbon-carbon bonds;metal ion binding;protein homodimerization activity","extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Butanoate metabolism;Carbon metabolism;Fatty acid degradation;Fatty acid metabolism;Glyoxylate and dicarboxylate metabolism;Lysine degradation;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism;Synthesis and degradation of ketone bodies;Terpenoid backbone biosynthesis;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,10,10,10,"38.9","38.9","38.9","45.199",0,"63.614",948900000,55,"0.0286309","0.966812","-0.0457401","-0.0904095","sp|P24752|THIL_HUMAN;tr|E9PRQ6|E9PRQ6_HUMAN;tr|H0YEL7|H0YEL7_HUMAN;tr|E9PKF3|E9PKF3_HUMAN","sp|P24752|THIL_HUMAN",791,"P24752","THIL_HUMAN","Acetyl-CoA acetyltransferase, mitochondrial",null,"ACAT1"]
["21.3375","20.9634","21.2276","21.1655",{"$nulls":3},"cell redox homeostasis","electron transfer activity;flavin adenine dinucleotide binding;thioredoxin-disulfide reductase activity","cell",{"$nulls":3},7,7,7,"19.7","19.7","19.7","53.166",0,"30.475",637810000,24,"0.0806355","0.928421","-0.0461016","-0.243158","tr|E9PIR7|E9PIR7_HUMAN;tr|F8W809|F8W809_HUMAN;tr|A0A087WSW9|A0A087WSW9_HUMAN;tr|E9PNQ6|E9PNQ6_HUMAN;tr|A0A087WSY9|A0A087WSY9_HUMAN;sp|Q16881|TRXR1_HUMAN;tr|E2QRB9|E2QRB9_HUMAN;tr|E9PKD3|E9PKD3_HUMAN;tr|E9PQI3|E9PQI3_HUMAN;tr|E9PLT3|E9PLT3_HUMAN;tr|E9PKI4|E9PKI4_HUMAN;tr|A0A0B4J225|A0A0B4J225_HUMAN;tr|E9PIZ5|E9PIZ5_HUMAN","tr|E9PIR7|E9PIR7_HUMAN;tr|F8W809|F8W809_HUMAN;tr|A0A087WSW9|A0A087WSW9_HUMAN;tr|E9PNQ6|E9PNQ6_HUMAN;tr|A0A087WSY9|A0A087WSY9_HUMAN;sp|Q16881|TRXR1_HUMAN;tr|E2QRB9|E2QRB9_HUMAN",1761,"E9PIR7","E9PIR7_HUMAN",null,null,"TXNRD1"]
["22.5722","22.4233","23.0284","22.0603",{"$nulls":3},"cellular response to interferon-gamma;negative regulation of formation of translation preinitiation complex;negative regulation of translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;focal adhesion;GAIT complex;intracellular ribonucleoprotein complex;large ribosomal subunit;membrane;nucleolus;nucleus","Ribosome",null,null,4,4,4,"19.2","19.2","19.2","23.577",0,"12.714",564510000,13,"0.0301637","0.96644","-0.0465736","-0.0951045","sp|P40429|RL13A_HUMAN;tr|M0QYS1|M0QYS1_HUMAN;tr|Q8J015|Q8J015_HUMAN;sp|Q6NVV1|R13P3_HUMAN","sp|P40429|RL13A_HUMAN;tr|M0QYS1|M0QYS1_HUMAN;tr|Q8J015|Q8J015_HUMAN;sp|Q6NVV1|R13P3_HUMAN",970,"P40429","RL13A_HUMAN","60S ribosomal protein L13a",null,"RPL13A"]
["20.9785","20.8042","20.9917","20.8843",{"$nulls":9},4,4,4,"15.6","15.6","15.6","36.888",0,"21.104",319290000,33,"0.15906","0.86623","-0.0466404","-0.455653","tr|H7C3G9|H7C3G9_HUMAN;sp|Q9UJ70|NAGK_HUMAN;tr|C9JEV6|C9JEV6_HUMAN;tr|H7C1L7|H7C1L7_HUMAN;tr|H7C286|H7C286_HUMAN;tr|H0YE82|H0YE82_HUMAN;tr|E9PPU6|E9PPU6_HUMAN;tr|H0YF44|H0YF44_HUMAN;tr|H0YEB7|H0YEB7_HUMAN","tr|H7C3G9|H7C3G9_HUMAN;sp|Q9UJ70|NAGK_HUMAN;tr|C9JEV6|C9JEV6_HUMAN;tr|H7C1L7|H7C1L7_HUMAN;tr|H7C286|H7C286_HUMAN",2854,"H7C3G9","H7C3G9_HUMAN",null,null,"NAGK"]
["20.2125","20.3708","20.8042","19.8746",{"$nulls":3},"isoleucyl-tRNA aminoacylation;osteoblast differentiation;tRNA aminoacylation for protein translation","aminoacyl-tRNA editing activity;ATP binding;GTPase binding;isoleucine-tRNA ligase activity;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;extracellular exosome;membrane","Aminoacyl-tRNA biosynthesis",null,null,16,16,16,"17.7","17.7","17.7","144.5",0,"61.291",774350000,57,"0.0321808","0.962915","-0.0477428","-0.101262","sp|P41252|SYIC_HUMAN;tr|J3KR24|J3KR24_HUMAN;tr|A0A0A0MSX9|A0A0A0MSX9_HUMAN;tr|Q5TCD1|Q5TCD1_HUMAN;tr|Q5TCC9|Q5TCC9_HUMAN;tr|Q5TCC6|Q5TCC6_HUMAN","sp|P41252|SYIC_HUMAN;tr|J3KR24|J3KR24_HUMAN;tr|A0A0A0MSX9|A0A0A0MSX9_HUMAN",986,"P41252","SYIC_HUMAN","Isoleucine--tRNA ligase, cytoplasmic",null,"IARS"]
["21.1396","21.3234","21.4639","21.095",{"$nulls":3},"mature ribosome assembly",null,"cytosol;nucleus",{"$nulls":3},3,3,3,"13.6","13.6","13.6","28.864",0,"6.6681",423030000,11,"0.076935","0.93114","-0.0479498","-0.232678","tr|A0A087X020|A0A087X020_HUMAN;sp|Q9Y3A5|SBDS_HUMAN;tr|F8WE72|F8WE72_HUMAN","tr|A0A087X020|A0A087X020_HUMAN;sp|Q9Y3A5|SBDS_HUMAN;tr|F8WE72|F8WE72_HUMAN",2978,"A0A087X020","A0A087X020_HUMAN",null,null,"SBDS"]
["17.423","17.2141","17.2003","17.5333",{"$nulls":3},"tRNA 5'-leader removal;tRNA catabolic process;tRNA processing","ribonuclease MRP activity;ribonuclease P activity;RNA binding","extracellular space;Golgi apparatus;intracellular membrane-bounded organelle;mitochondrion;multimeric ribonuclease P complex;nucleolar ribonuclease P complex;nucleolus;nucleoplasm;ribonuclease MRP complex","Ribosome biogenesis in eukaryotes;RNA transport",null,null,3,3,3,"4.6","4.6","4.6","114.71",0,"7.1194",80767000,6,"0.0814157","0.929479","-0.0482283","-0.245362","sp|Q99575|POP1_HUMAN;tr|E5RK39|E5RK39_HUMAN","sp|Q99575|POP1_HUMAN;tr|E5RK39|E5RK39_HUMAN",2383,"Q99575","POP1_HUMAN","Ribonucleases P/MRP protein subunit POP1","POP1","POP1"]
["18.2585","19.0377","18.2069","19.1865",{"$nulls":3},"early endosome to Golgi transport;endocytosis;intracellular protein transport;vesicle organization","identical protein binding;phosphatidylinositol binding","cytosol;early endosome membrane;extrinsic component of membrane;intracellular membrane-bounded organelle",{"$nulls":3},3,3,3,"7.1","7.1","7.1","52.569",0,"8.4988",95719000,14,"0.0244767","0.970788","-0.0485792","-0.0776168","sp|Q9Y5X2|SNX8_HUMAN;tr|C9J271|C9J271_HUMAN","sp|Q9Y5X2|SNX8_HUMAN",3030,"Q9Y5X2","SNX8_HUMAN","Sorting nexin-8",null,"SNX8"]
["18.4167","18.6508","18.5253","18.6399",{"$nulls":4},"GTP binding;GTPase activity","cytoplasm;nucleus",{"$nulls":3},4,4,4,"7.7","7.7","7.7","79.548",0,"41.189",101910000,10,"0.128511","0.897662","-0.0488281","-0.374743","sp|Q3YEC7|RABL6_HUMAN;tr|B1AMX5|B1AMX5_HUMAN;tr|G3V154|G3V154_HUMAN;tr|F2Z2T0|F2Z2T0_HUMAN","sp|Q3YEC7|RABL6_HUMAN;tr|B1AMX5|B1AMX5_HUMAN;tr|G3V154|G3V154_HUMAN;tr|F2Z2T0|F2Z2T0_HUMAN",1782,"Q3YEC7","RABL6_HUMAN","Rab-like protein 6",null,"RABL6"]
["22.8142","22.6698","23.1496","22.4323",{"$nulls":3},"L-serine biosynthetic process;pyridoxine biosynthetic process","O-phospho-L-serine:2-oxoglutarate aminotransferase activity","cytoplasm;cytosol;extracellular exosome","Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways;Vitamin B6 metabolism",null,null,7,7,7,"25.4","25.4","25.4","40.422",0,"17.62",1521500000,15,"0.0429881","0.954474","-0.048975","-0.133875","sp|Q9Y617|SERC_HUMAN","sp|Q9Y617|SERC_HUMAN",3037,"Q9Y617","SERC_HUMAN","Phosphoserine aminotransferase",null,"PSAT1"]
["20.036","19.6337","19.7962","19.9718",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of viral transcription;response to virus;RNA metabolic process;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","DNA binding;phosphatase activator activity;protein domain specific binding;protein phosphatase binding;RNA binding;transcription coactivator activity;transcription factor binding","cell junction;intracellular membrane-bounded organelle;nucleoplasm;nucleus;protein complex;transcription factor TFIID complex;transcription factor TFIIF complex","Basal transcription factors",null,null,8,8,8,"21.7","21.7","21.7","58.24",0,"72.47",169000000,37,"0.073817","0.930522","-0.0491257","-0.223806","sp|P35269|T2FA_HUMAN;tr|M0QXD6|M0QXD6_HUMAN;tr|M0R0Z3|M0R0Z3_HUMAN;tr|M0R0R9|M0R0R9_HUMAN","sp|P35269|T2FA_HUMAN;tr|M0QXD6|M0QXD6_HUMAN",929,"P35269","T2FA_HUMAN","General transcription factor IIF subunit 1",null,"GTF2F1"]
["22.2565","22.2128","22.4846","22.0834",{"$nulls":3},"positive regulation of proteasomal ubiquitin-dependent protein catabolic process;protein deubiquitination;protein K48-linked deubiquitination;protein ubiquitination;ubiquitin-dependent protein catabolic process","cysteine-type endopeptidase activity;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitin binding;zinc ion binding","cytosol;lysosome",{"$nulls":3},20,20,20,"33.4","33.4","33.4","95.785",0,"165.33",1904900000,114,"0.0811644","0.928759","-0.0493631","-0.244652","sp|P45974|UBP5_HUMAN;tr|F5H571|F5H571_HUMAN","sp|P45974|UBP5_HUMAN",1018,"P45974","UBP5_HUMAN","Ubiquitin carboxyl-terminal hydrolase 5",null,"USP5"]
["19.4899","19.3931","20.0964","18.8864",{"$nulls":3},"cellular response to interferon-beta;free ubiquitin chain polymerization;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;positive regulation of peptidyl-threonine phosphorylation;positive regulation of type I interferon-mediated signaling pathway;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K48-linked ubiquitination;protein ubiquitination;regulation of proteasomal ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process","ATP binding;ubiquitin protein ligase binding;ubiquitin-protein transferase activity;ubiquitin-ubiquitin ligase activity","cytoplasm;cytosol;extracellular exosome;filopodium tip;nucleus","Ubiquitin mediated proteolysis",null,null,3,3,3,"27.5","27.5","27.5","22.406",0,"8.6808",66369000,10,"0.0259448","0.967186","-0.0498581","-0.0821493","sp|P61086|UBE2K_HUMAN;tr|D6RDM7|D6RDM7_HUMAN","sp|P61086|UBE2K_HUMAN;tr|D6RDM7|D6RDM7_HUMAN",1256,"P61086","UBE2K_HUMAN","Ubiquitin-conjugating enzyme E2 K",null,"UBE2K"]
["19.518","19.2403","19.7695","19.09",{"$nulls":3},"animal organ morphogenesis;axon guidance;cell cycle arrest;cell proliferation;cell surface receptor signaling pathway;cellular response to gamma radiation;cellular senescence;chemotaxis;defense response to protozoan;endocytosis;ephrin receptor signaling pathway;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;Fc-epsilon receptor signaling pathway;intrinsic apoptotic signaling pathway;leukocyte migration;MAPK cascade;mitotic cell cycle checkpoint;negative regulation of cell proliferation;negative regulation of gene expression;negative regulation of GTPase activity;negative regulation of neuron apoptotic process;positive regulation of actin cytoskeleton reorganization;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of DNA replication;positive regulation of epithelial cell proliferation;positive regulation of ERK1 and ERK2 cascade;positive regulation of GTPase activity;positive regulation of interferon-gamma production;positive regulation of JNK cascade;positive regulation of MAP kinase activity;positive regulation of MAPK cascade;positive regulation of miRNA metabolic process;positive regulation of protein phosphorylation;positive regulation of Ras protein signal transduction;positive regulation of ruffle assembly;positive regulation of transcription from RNA polymerase II promoter;positive regulation of wound healing;protein heterooligomerization;Ras protein signal transduction;regulation of long-term neuronal synaptic plasticity;response to isolation stress;signal transduction;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;T-helper 1 type immune response","GDP binding;GTP binding;GTPase activity;protein C-terminus binding","cytoplasm;cytosol;Golgi apparatus;Golgi membrane;nucleus;perinuclear region of cytoplasm;plasma membrane","Acute myeloid leukemia;AGE-RAGE signaling pathway in diabetic complications;Alcoholism;Apelin signaling pathway;Apoptosis;Autophagy - animal;Axon guidance;B cell receptor signaling pathway;Bladder cancer;Breast cancer;Cellular senescence;Central carbon metabolism in cancer;Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;C-type lectin receptor signaling pathway;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endocytosis;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Focal adhesion;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Insulin signaling pathway;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Longevity regulating pathway;Longevity regulating pathway - multiple species;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;MicroRNAs in cancer;Mitophagy - animal;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-small cell lung cancer;Oxytocin signaling pathway;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Serotonergic synapse;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thermogenesis;Thyroid cancer;Thyroid hormone signaling pathway;VEGF signaling pathway;Viral carcinogenesis",null,null,3,3,3,"25.4","25.4","25.4","21.298","0.0047506","1.9938",77558000,4,"0.0443439","0.955459","-0.0506229","-0.137923","sp|P01112|RASH_HUMAN;sp|P01111|RASN_HUMAN;sp|P01116|RASK_HUMAN;tr|G3V4K2|G3V4K2_HUMAN;tr|G3V5T7|G3V5T7_HUMAN","sp|P01112|RASH_HUMAN;sp|P01111|RASN_HUMAN;sp|P01116|RASK_HUMAN",479,"P01112","RASH_HUMAN","GTPase HRas",null,"HRAS"]
["18.3685","18.8164","18.7411","18.5459",{"$nulls":5},"actin cytoskeleton;cytosol",{"$nulls":3},8,8,8,"14.1","14.1","14.1","95.928",0,"68.528",251900000,33,"0.0685415","0.935951","-0.0509911","-0.20871","tr|J3KSW8|J3KSW8_HUMAN;sp|Q6WCQ1|MPRIP_HUMAN;tr|H0Y2S9|H0Y2S9_HUMAN;tr|H0Y7E2|H0Y7E2_HUMAN;tr|H7C3G6|H7C3G6_HUMAN","tr|J3KSW8|J3KSW8_HUMAN;sp|Q6WCQ1|MPRIP_HUMAN;tr|H0Y2S9|H0Y2S9_HUMAN;tr|H0Y7E2|H0Y7E2_HUMAN",1908,"J3KSW8","J3KSW8_HUMAN",null,null,"MPRIP"]
["23.0273","23.0375","23.2386","22.9291",{"$nulls":3},"folic acid metabolic process;glycine biosynthetic process from serine;glycine metabolic process;L-serine biosynthetic process;L-serine metabolic process;one-carbon metabolic process;positive regulation of cell proliferation;protein homotetramerization;protein K63-linked deubiquitination;protein tetramerization;response to type I interferon;tetrahydrofolate interconversion;tetrahydrofolate metabolic process","amino acid binding;chromatin binding;glycine hydroxymethyltransferase activity;identical protein binding;L-allo-threonine aldolase activity;pyridoxal phosphate binding","BRISC complex;cytoplasm;extracellular exosome;microtubule cytoskeleton;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleus","Antifolate resistance;Biosynthesis of amino acids;Carbon metabolism;Glycine, serine and threonine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;One carbon pool by folate",null,null,15,15,14,"38.3","38.3","35.5","55.992",0,"323.31",2447800000,77,"0.11267","0.904919","-0.051404","-0.331946","sp|P34897|GLYM_HUMAN;tr|H0YIZ0|H0YIZ0_HUMAN;tr|G3V2Y4|G3V2Y4_HUMAN;tr|G3V5L0|G3V5L0_HUMAN;tr|G3V540|G3V540_HUMAN;tr|G3V4W5|G3V4W5_HUMAN;tr|G3V241|G3V241_HUMAN;tr|G3V3Y8|G3V3Y8_HUMAN;tr|G3V4T0|G3V4T0_HUMAN;tr|G3V4X0|G3V4X0_HUMAN;tr|G3V2W0|G3V2W0_HUMAN;tr|G3V2E4|G3V2E4_HUMAN;tr|G3V2Y1|G3V2Y1_HUMAN;tr|G3V3C6|G3V3C6_HUMAN","sp|P34897|GLYM_HUMAN;tr|H0YIZ0|H0YIZ0_HUMAN;tr|G3V2Y4|G3V2Y4_HUMAN",916,"P34897","GLYM_HUMAN","Serine hydroxymethyltransferase, mitochondrial","HMT","SHMT2"]
["21.1355","20.9802","21.4561","20.763",{"$nulls":3},"adherens junction assembly;apical junction assembly;axon extension;cell adhesion;cell-matrix adhesion;epithelial cell-cell adhesion;lamellipodium assembly;morphogenesis of an epithelium;movement of cell or subcellular component;muscle contraction;negative regulation of cell migration;neutrophil degranulation;platelet aggregation;platelet degranulation;protein localization to cell surface","actin binding;alpha-catenin binding;beta-catenin binding;cadherin binding;dystroglycan binding;structural molecule activity;ubiquitin protein ligase binding","adherens junction;brush border;cell;cell-cell adherens junction;cell-cell junction;cell-substrate junction;costamere;cytoskeleton;cytosol;extracellular exosome;extracellular region;extracellular vesicle;fascia adherens;ficolin-1-rich granule lumen;focal adhesion;inner dense plaque of desmosome;membrane raft;outer dense plaque of desmosome;plasma membrane;podosome;protein complex;sarcolemma;secretory granule lumen;specific granule lumen;terminal web;zonula adherens","Adherens junction;Amoebiasis;Bacterial invasion of epithelial cells;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Shigellosis",null,null,26,26,26,"34.1","34.1","34.1","123.8",0,"251.79",2127200000,115,"0.0469923","0.955118","-0.0517807","-0.145804","sp|P18206|VINC_HUMAN;tr|Q5JQ13|Q5JQ13_HUMAN;tr|A0A096LPE1|A0A096LPE1_HUMAN","sp|P18206|VINC_HUMAN;tr|Q5JQ13|Q5JQ13_HUMAN",720,"P18206","VINC_HUMAN","Vinculin",null,"VCL"]
["19.8145","19.6596","19.6537","19.9242",{"$nulls":3},"methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione","hydroxyacylglutathione hydrolase activity",{"$nulls":4},2,2,2,"11.7","11.7","11.7","26.305",0,"6.9252",111090000,4,"0.113045","0.904913","-0.051899","-0.332967","tr|H3BPK3|H3BPK3_HUMAN;sp|Q16775|GLO2_HUMAN;tr|H3BV79|H3BV79_HUMAN;tr|H3BQW8|H3BQW8_HUMAN;tr|H3BPQ4|H3BPQ4_HUMAN","tr|H3BPK3|H3BPK3_HUMAN;sp|Q16775|GLO2_HUMAN;tr|H3BV79|H3BV79_HUMAN;tr|H3BQW8|H3BQW8_HUMAN;tr|H3BPQ4|H3BPQ4_HUMAN",1756,"H3BPK3","H3BPK3_HUMAN",null,null,"HAGH"]
["19.8513","20.6261","19.7875","20.7949",{"$nulls":3},"N-terminal protein amino acid modification;peptidyl-methionine modification;protein processing;regulation of rhodopsin mediated signaling pathway","aminopeptidase activity;metal ion binding;metalloexopeptidase activity;RNA binding","cytoplasm;cytosol;plasma membrane",{"$nulls":3},6,6,6,19,19,19,"52.891",0,"40.765",295440000,19,"0.026072","0.967488","-0.0524511","-0.0825416","sp|P50579|MAP2_HUMAN;tr|F8VQZ7|F8VQZ7_HUMAN;tr|G3V1U3|G3V1U3_HUMAN;tr|F8VRR3|F8VRR3_HUMAN;tr|F8VSC4|F8VSC4_HUMAN;tr|F8VY03|F8VY03_HUMAN;tr|F8VZX9|F8VZX9_HUMAN","sp|P50579|MAP2_HUMAN;tr|F8VQZ7|F8VQZ7_HUMAN;tr|G3V1U3|G3V1U3_HUMAN;tr|F8VRR3|F8VRR3_HUMAN;tr|F8VSC4|F8VSC4_HUMAN",1119,"P50579","MAP2_HUMAN","Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}","AP 2 {ECO:0000255|HAMAP-Rule:MF_03175};etAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}","METAP2"]
["15.6752","15.6417","15.9004","15.5237",{"$nulls":4},"RNA binding","mitochondrion",{"$nulls":3},2,2,2,"8.6","8.6","8.6","49.996","0.003112","2.1517",14353000,2,"0.0950131","0.919817","-0.0535812","-0.283416","sp|Q96I51|WBS16_HUMAN;tr|A0A087WT38|A0A087WT38_HUMAN","sp|Q96I51|WBS16_HUMAN;tr|A0A087WT38|A0A087WT38_HUMAN",2294,"Q96I51","RCC1L_HUMAN","RCC1-like G exchanging factor-like protein","CC1 like","RCC1L"]
["17.9488","18.3317","18.6568","17.7344",{"$nulls":3},"cristae formation;mitochondrial respiratory chain complex assembly;protein import into mitochondrial outer membrane",null,"extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrial sorting and assembly machinery complex;mitochondrion",{"$nulls":3},3,3,3,"9.6","9.6","9.6","51.976",0,"8.389",81547000,19,"0.0353479","0.960327","-0.0553741","-0.110884","sp|Q9Y512|SAM50_HUMAN","sp|Q9Y512|SAM50_HUMAN",3009,"Q9Y512","SAM50_HUMAN","Sorting and assembly machinery component 50 homolog",null,"SAMM50"]
["18.7708","18.8075","19.0979","18.5923",{"$nulls":4},"DNA binding;lamin binding","cytoplasm;integral component of membrane;membrane;nuclear envelope;nuclear inner membrane;nuclear membrane;nucleus",{"$nulls":3},9,4,4,"34.4","13.7","13.7","50.67",0,"5.2602",83027000,10,"0.0728238","0.93115","-0.0560112","-0.220973","sp|P42167|LAP2B_HUMAN;tr|G5E972|G5E972_HUMAN;tr|H0YJH7|H0YJH7_HUMAN","sp|P42167|LAP2B_HUMAN;tr|G5E972|G5E972_HUMAN;tr|H0YJH7|H0YJH7_HUMAN",991,"P42167","LAP2B_HUMAN","Lamina-associated polypeptide 2, isoforms beta/gamma",null,"TMPO"]
[1,"14.4395",1,"14.5517",{"$nulls":3},"acute-phase response;angiogenesis;calcium-independent cell-matrix adhesion;cell adhesion;cell-substrate junction assembly;cellular protein metabolic process;endodermal cell differentiation;extracellular matrix disassembly;extracellular matrix organization;integrin activation;interaction with other organism via secreted substance involved in symbiotic interaction;interaction with symbiont;leukocyte migration;negative regulation of transforming growth factor-beta secretion;peptide cross-linking;platelet degranulation;positive regulation of axon extension;positive regulation of cell proliferation;positive regulation of fibroblast proliferation;positive regulation of gene expression;positive regulation of substrate-dependent cell migration, cell attachment to substrate;post-translational protein modification;regulation of cell shape;regulation of ERK1 and ERK2 cascade;regulation of protein phosphorylation;response to wounding;substrate adhesion-dependent cell spreading;wound healing","chaperone binding;collagen binding;disordered domain specific binding;enzyme binding;heparin binding;identical protein binding;integrin binding;peptidase activator activity;protease binding;protein C-terminus binding;receptor binding","apical plasma membrane;basal lamina;blood microparticle;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular matrix;extracellular region;extracellular space;fibrinogen complex;platelet alpha granule lumen;proteinaceous extracellular matrix","AGE-RAGE signaling pathway in diabetic complications;Amoebiasis;Bacterial invasion of epithelial cells;ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Pathways in cancer;PI3K-Akt signaling pathway;Proteoglycans in cancer;Regulation of actin cytoskeleton;Small cell lung cancer;Yersinia infection",null,null,1,1,1,"0.5","0.5","0.5","262.62",0,"15.832",17561000,4,"0.00180908","0.994968","-0.0561008","-0.00587879","sp|P02751|FINC_HUMAN","sp|P02751|FINC_HUMAN",482,"P02751","FINC_HUMAN","Fibronectin","N","FN1"]
["18.4519","18.8815","19.5697","17.8769",{"$nulls":9},2,2,2,"8.7","8.7","8.7","30.896",0,"4.119",92862000,7,"0.0203525","0.974479","-0.0565977","-0.0648138","tr|Q5JUV4|Q5JUV4_HUMAN;sp|P49902|5NTC_HUMAN;tr|S4R3E7|S4R3E7_HUMAN;tr|S4R3A6|S4R3A6_HUMAN","tr|Q5JUV4|Q5JUV4_HUMAN;sp|P49902|5NTC_HUMAN;tr|S4R3E7|S4R3E7_HUMAN;tr|S4R3A6|S4R3A6_HUMAN",1103,"Q5JUV4","Q5JUV4_HUMAN",null,null,"NT5C2"]
["18.9493","18.7167","19.3667","18.4139",{"$nulls":3},"carbohydrate metabolic process","beta-galactosidase activity","Golgi apparatus;intracellular membrane-bounded organelle",{"$nulls":3},3,3,3,"6.6","6.6","6.6","60.482",0,"4.1287",65848000,9,"0.0373097","0.957687","-0.0572824","-0.116817","tr|E7EQ29|E7EQ29_HUMAN;sp|P16278|BGAL_HUMAN;tr|F8WF40|F8WF40_HUMAN;tr|C9JF15|C9JF15_HUMAN;tr|C9JWX1|C9JWX1_HUMAN","tr|E7EQ29|E7EQ29_HUMAN;sp|P16278|BGAL_HUMAN",695,"E7EQ29","E7EQ29_HUMAN",null,null,"GLB1"]
["19.6142","19.4325","19.8548","19.3082",{"$nulls":3},"neutrophil degranulation","metal ion binding;phosphoprotein phosphatase activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region;plasma membrane",{"$nulls":3},2,2,2,"6.1","6.1","6.1","35.548",0,"15.144",123880000,14,"0.0661639","0.935888","-0.0581427","-0.201869","sp|Q9BRF8|CPPED_HUMAN","sp|Q9BRF8|CPPED_HUMAN",2425,"Q9BRF8","CPPED_HUMAN","Serine/threonine-protein phosphatase CPPED1",null,"CPPED1"]
["21.0812","20.4311","21.2422","20.387",{"$nulls":3},"citrate metabolic process;generation of precursor metabolites and energy;isocitrate metabolic process;liver development;response to isolation stress;tricarboxylic acid cycle","3 iron, 4 sulfur cluster binding;4 iron, 4 sulfur cluster binding;aconitate hydratase activity;iron ion binding","mitochondrial matrix;mitochondrion;myelin sheath","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Metabolic pathways",null,null,11,11,11,"21.2","21.2","21.2","85.424",0,"31.94",617090000,67,"0.0346708","0.961328","-0.0584526","-0.108832","sp|Q99798|ACON_HUMAN;tr|A2A274|A2A274_HUMAN","sp|Q99798|ACON_HUMAN;tr|A2A274|A2A274_HUMAN",2396,"Q99798","ACON_HUMAN","Aconitate hydratase, mitochondrial","conitase","ACO2"]
["21.2409","21.3216","21.506","21.1735",{"$nulls":3},"activation of signaling protein activity involved in unfolded protein response;cellular calcium ion homeostasis;COPII-coated vesicle budding;endoplasmic reticulum organization;endoplasmic reticulum unfolded protein response;ER to Golgi vesicle-mediated transport;modulation by host of viral RNA genome replication;modulation by virus of host morphology or physiology;negative regulation by host of viral genome replication;negative regulation by host of viral release from host cell;negative regulation by virus of viral protein levels in host cell;positive regulation by host of viral genome replication;positive regulation by host of viral release from host cell;positive regulation of viral genome replication;sphingolipid biosynthetic process","beta-tubulin binding;cadherin binding;enzyme binding;FFAT motif binding;microtubule binding;protein heterodimerization activity;protein homodimerization activity","cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;integral component of membrane","Cholesterol metabolism",null,null,6,5,5,"23.9","18.9","18.9","27.228",0,"16.818",332020000,23,"0.116382","0.904212","-0.0585213","-0.342034","sp|O95292|VAPB_HUMAN;tr|E5RK64|E5RK64_HUMAN","sp|O95292|VAPB_HUMAN",422,"O95292","VAPB_HUMAN","Vesicle-associated membrane protein-associated protein B/C","AMP-associated protein B/C;AMP-B/VAMP-C;AP-B/VAP-C","VAPB"]
["20.8287","20.5995","21.0768","20.4693",{"$nulls":3},"enzyme linked receptor protein signaling pathway;tissue development",null,"endoplasmic reticulum",{"$nulls":3},6,5,5,"25.5","22.1","22.1","29.224",0,"16.837",271360000,34,"0.0591431","0.943943","-0.0589323","-0.181529","tr|F8W031|F8W031_HUMAN;tr|F8VXJ7|F8VXJ7_HUMAN;sp|Q9Y2B0|CNPY2_HUMAN;tr|F8W1K5|F8W1K5_HUMAN;tr|F8VP03|F8VP03_HUMAN;tr|H0YIH9|H0YIH9_HUMAN;tr|F8W0J2|F8W0J2_HUMAN;tr|H0YI18|H0YI18_HUMAN;tr|F8W1U5|F8W1U5_HUMAN;tr|F8VWQ5|F8VWQ5_HUMAN","tr|F8W031|F8W031_HUMAN;tr|F8VXJ7|F8VXJ7_HUMAN;sp|Q9Y2B0|CNPY2_HUMAN;tr|F8W1K5|F8W1K5_HUMAN",3097,"F8W031","F8W031_HUMAN"]
["16.72","16.7216","17.4911","16.0695",{"$nulls":3},"aging;extracellular matrix organization;follicular dendritic cell differentiation;germinal center formation;I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;negative regulation of transcription from RNA polymerase II promoter;NIK/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;regulation of transcription, DNA-templated;response to cytokine;response to lipopolysaccharide;rhythmic process;spleen development","chromatin binding;DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcription coactivator activity;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","Bcl3/NF-kappaB2 complex;cytoplasm;cytosol;nucleoplasm;nucleus","Breast cancer;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Human T-cell leukemia virus 1 infection;Legionellosis;MAPK signaling pathway;NF-kappa B signaling pathway;Osteoclast differentiation;Pathways in cancer;Viral carcinogenesis",null,null,2,2,2,"3.3","3.3","3.3","96.748",0,"34.49",48767000,13,"0.0264297","0.967528","-0.0594549","-0.0836439","sp|Q00653|NFKB2_HUMAN","sp|Q00653|NFKB2_HUMAN",1407,"Q00653","NFKB2_HUMAN","Nuclear factor NF-kappa-B p100 subunit",null,"NFKB2"]
["19.7039","20.1094","19.958","19.9788",{"$nulls":4},"DNA binding transcription factor activity;proximal promoter sequence-specific DNA binding","nucleus",{"$nulls":3},1,1,1,"2.2","2.2","2.2","75.311",0,"5.2673",43547000,1,"0.102558","0.913082","-0.0617809","-0.304267","tr|H0Y6K5|H0Y6K5_HUMAN;tr|H0Y7L6|H0Y7L6_HUMAN;sp|Q02447|SP3_HUMAN","tr|H0Y6K5|H0Y6K5_HUMAN;tr|H0Y7L6|H0Y7L6_HUMAN;sp|Q02447|SP3_HUMAN",1429,"H0Y6K5","H0Y6K5_HUMAN",null,null,"SP3"]
["19.8337","19.7242","20.7091","18.9767",{"$nulls":3},"multicellular organism development;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;metal ion binding","nucleus",{"$nulls":3},1,1,1,"2.6","2.6","2.6","45.967","0.001083","2.4863",109580000,9,"0.0232034","0.971349","-0.0639448","-0.0736751","tr|B7Z934|B7Z934_HUMAN;sp|Q9HAK2|COE2_HUMAN","tr|B7Z934|B7Z934_HUMAN;sp|Q9HAK2|COE2_HUMAN",2628,"B7Z934","B7Z934_HUMAN",null,null,"EBF2"]
["20.618","20.2738","20.7526","20.2672",{"$nulls":3},"aspartate transport;ATP biosynthetic process;cellular respiration;gluconeogenesis;L-glutamate transport;malate-aspartate shuttle;mitochondrial transport;response to calcium ion","acidic amino acid transmembrane transporter activity;calcium ion binding;L-aspartate transmembrane transporter activity;L-glutamate transmembrane transporter activity;transporter activity","integral component of membrane;integral component of plasma membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},9,9,8,"21.8","21.8",20,"74.175",0,"72.221",487910000,42,"0.0707694","0.934507","-0.0640039","-0.215099","sp|Q9UJS0|CMC2_HUMAN;tr|R4GN64|R4GN64_HUMAN","sp|Q9UJS0|CMC2_HUMAN",2858,"Q9UJS0","CMC2_HUMAN","Calcium-binding mitochondrial carrier protein Aralar2",null,"SLC25A13"]
["20.5542","20.1326","20.5437","20.2716",{"$nulls":4},"fatty-acyl-CoA binding",{"$nulls":4},3,3,3,"38.6","38.6","38.6","15.64",0,"7.924",88159000,14,"0.0852285","0.926338","-0.0642548","-0.256097","tr|F8WAW4|F8WAW4_HUMAN;tr|F1LLU7|F1LLU7_HUMAN;tr|C9JB63|C9JB63_HUMAN;tr|A0A0C4DGA2|A0A0C4DGA2_HUMAN;sp|O75521|ECI2_HUMAN;tr|F8W6J1|F8W6J1_HUMAN","tr|F8WAW4|F8WAW4_HUMAN;tr|F1LLU7|F1LLU7_HUMAN;tr|C9JB63|C9JB63_HUMAN;tr|A0A0C4DGA2|A0A0C4DGA2_HUMAN;sp|O75521|ECI2_HUMAN",350,"F8WAW4","F8WAW4_HUMAN",null,null,"ECI2"]
["21.5775","21.4691","22.138","21.0388",{"$nulls":3},"adaptive immune response;cellular response to DNA damage stimulus;cellular response to interleukin-1;DNA repair;negative regulation of double-strand break repair;negative regulation of histone H2A K63-linked ubiquitination;protein deubiquitination;protein K48-linked deubiquitination","NEDD8-specific protease activity;thiol-dependent ubiquitin-specific protease activity;ubiquitin binding;ubiquitin protein ligase binding","cytosol;extracellular exosome;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"23.2","23.2","23.2","31.284",0,"10.544",446450000,17,"0.037643","0.957656","-0.0650682","-0.117823","sp|Q96FW1|OTUB1_HUMAN;tr|J3KR44|J3KR44_HUMAN;tr|F5GYN4|F5GYN4_HUMAN;tr|F5H6Q1|F5H6Q1_HUMAN;tr|F5GYJ8|F5GYJ8_HUMAN;tr|F5H3F0|F5H3F0_HUMAN","sp|Q96FW1|OTUB1_HUMAN;tr|J3KR44|J3KR44_HUMAN;tr|F5GYN4|F5GYN4_HUMAN;tr|F5H6Q1|F5H6Q1_HUMAN;tr|F5GYJ8|F5GYJ8_HUMAN;tr|F5H3F0|F5H3F0_HUMAN",2269,"Q96FW1","OTUB1_HUMAN","Ubiquitin thioesterase OTUB1",null,"OTUB1"]
["25.8482","25.6665","25.9845","25.6606",{"$nulls":3},"protein folding","ATP binding","cytoplasm",{"$nulls":3},5,5,2,"48.5","48.5","19.8","10.689",0,"24.71",3327300000,32,"0.119757","0.902403","-0.0652056","-0.351174","tr|B8ZZL8|B8ZZL8_HUMAN;sp|P61604|CH10_HUMAN;tr|B8ZZ54|B8ZZ54_HUMAN","tr|B8ZZL8|B8ZZL8_HUMAN;sp|P61604|CH10_HUMAN",1276,"B8ZZL8","B8ZZL8_HUMAN"]
["15.53","14.7004","15.6117","14.7493",{"$nulls":3},"amino acid transmembrane transport;bone development;sodium ion transport","amino acid transmembrane transporter activity","Golgi apparatus;integral component of membrane",{"$nulls":3},3,3,3,"3.7","3.7","3.7","119.76",0,"9.2837",29381000,9,"0.034759","0.961314","-0.065279","-0.1091","sp|Q9HBR0|S38AA_HUMAN","sp|Q9HBR0|S38AA_HUMAN",2637,"Q9HBR0","S38AA_HUMAN","Putative sodium-coupled neutral amino acid transporter 10",null,"SLC38A10"]
["19.7965","19.259","20.4227","18.7642",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,1,1,1,"11.3","11.3","11.3","12.517",0,"4.486",45591000,4,"0.0237517","0.971197","-0.0657024","-0.0753736","sp|O43920|NDUS5_HUMAN","sp|O43920|NDUS5_HUMAN",276,"O43920","NDUS5_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 5",null,"NDUFS5"]
["20.1226","19.7079","19.9989","19.9634",{"$nulls":3},"macroautophagy;protein targeting to mitochondrion","protein transmembrane transporter activity","extracellular exosome;integral component of membrane;membrane;mitochondrial outer membrane;mitochondrial outer membrane translocase complex;mitochondrion",{"$nulls":3},7,7,7,"13.7","13.7","13.7","67.454",0,"20.587",272130000,34,"0.107084","0.912264","-0.065918","-0.316694","sp|O94826|TOM70_HUMAN","sp|O94826|TOM70_HUMAN",393,"O94826","TOM70_HUMAN","Mitochondrial import receptor subunit TOM70",null,"TOMM70"]
["25.8995","25.5302","25.963","25.599",{"$nulls":3},"activation of MAPK activity;anterograde axonal transport;auditory receptor cell stereocilium organization;cell aging;cellular iron ion homeostasis;cellular response to ATP;cellular response to cadmium ion;cellular response to oxidative stress;cellular response to potassium ion;embryo implantation;glutathione metabolic process;heart contraction;hydrogen peroxide biosynthetic process;interleukin-12-mediated signaling pathway;locomotory behavior;muscle cell cellular homeostasis;myeloid cell homeostasis;negative regulation of cholesterol biosynthetic process;negative regulation of neuron apoptotic process;neurofilament cytoskeleton organization;ovarian follicle development;peripheral nervous system myelin maintenance;placenta development;platelet degranulation;positive regulation of apoptotic process;positive regulation of catalytic activity;positive regulation of cytokine production;positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;positive regulation of superoxide anion generation;reactive oxygen species metabolic process;regulation of blood pressure;regulation of GTPase activity;regulation of mitochondrial membrane potential;regulation of multicellular organism growth;regulation of organ growth;regulation of protein kinase activity;regulation of T cell differentiation in thymus;relaxation of vascular smooth muscle;removal of superoxide radicals;response to amphetamine;response to antibiotic;response to antipsychotic drug;response to axon injury;response to carbon monoxide;response to copper ion;response to drug;response to ethanol;response to heat;response to hydrogen peroxide;response to nutrient levels;response to organic substance;response to superoxide;retina homeostasis;retrograde axonal transport;sensory perception of sound;spermatogenesis;superoxide anion generation;superoxide metabolic process;thymus development;transmission of nerve impulse","chaperone binding;copper ion binding;identical protein binding;protein homodimerization activity;protein phosphatase 2B binding;Rac GTPase binding;superoxide dismutase activity;zinc ion binding","axon cytoplasm;cytoplasm;cytoplasmic vesicle;cytosol;dendrite cytoplasm;dense core granule;extracellular exosome;extracellular matrix;extracellular region;extracellular space;lysosome;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;myelin sheath;neuronal cell body;nucleoplasm;nucleus;peroxisome;protein complex","Amyotrophic lateral sclerosis (ALS);Huntington disease;Longevity regulating pathway - multiple species;Peroxisome;Prion diseases",null,null,4,4,4,"35.1","35.1","35.1","15.936",0,"128.73",4078100000,48,"0.0849189","0.926005","-0.066165","-0.255227","sp|P00441|SODC_HUMAN;tr|H7BYH4|H7BYH4_HUMAN","sp|P00441|SODC_HUMAN;tr|H7BYH4|H7BYH4_HUMAN",468,"P00441","SODC_HUMAN","Superoxide dismutase [Cu-Zn]",null,"SOD1"]
["22.0824","21.8464","22.787","21.2762",{"$nulls":9},2,2,2,"44.4","44.4","44.4","5.9149",0,"4.1507",172780000,9,"0.027811","0.967143","-0.0671959","-0.0878927","tr|C9JJT5|C9JJT5_HUMAN;sp|P56134|ATPK_HUMAN;tr|C9JU26|C9JU26_HUMAN;tr|G3V325|G3V325_HUMAN","tr|C9JJT5|C9JJT5_HUMAN;sp|P56134|ATPK_HUMAN;tr|C9JU26|C9JU26_HUMAN;tr|G3V325|G3V325_HUMAN",1219,"C9JJT5","C9JJT5_HUMAN",null,null,"ATP5MF-PTCD1"]
["19.7517","20.58","20.4429","20.0236",{"$nulls":9},1,1,1,"20.5","20.5","20.5","7.9963","0.0053691","1.9003",10724000,5,"0.0467993","0.954782","-0.0674162","-0.145231","tr|I3L4L3|I3L4L3_HUMAN;sp|Q9GZT4|SRR_HUMAN","tr|I3L4L3|I3L4L3_HUMAN;sp|Q9GZT4|SRR_HUMAN",2542,"I3L4L3","I3L4L3_HUMAN",null,null,"SRR"]
["22.4996","22.1305","22.7341","22.0324",{"$nulls":3},"erythrocyte differentiation;iron ion homeostasis;iron ion transport","ion transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},10,10,10,"40.7","40.7","40.7","35.619",0,"79.825",682870000,43,"0.0558853","0.945231","-0.0681896","-0.172018","sp|Q9H9B4|SFXN1_HUMAN;tr|D6RFI0|D6RFI0_HUMAN;tr|S4R2X2|S4R2X2_HUMAN;tr|D6RDG7|D6RDG7_HUMAN;tr|D6RAE9|D6RAE9_HUMAN","sp|Q9H9B4|SFXN1_HUMAN;tr|D6RFI0|D6RFI0_HUMAN;tr|S4R2X2|S4R2X2_HUMAN",2621,"Q9H9B4","SFXN1_HUMAN","Sideroflexin-1",null,"SFXN1"]
["20.4028","20.5152","19.9518","21.1032",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion","Ribosome",null,null,2,2,2,"22.8","22.8","22.8","15.947",0,"8.089",147500000,19,"0.0378238","0.957277","-0.0684681","-0.118369","sp|Q6P1L8|RM14_HUMAN","sp|Q6P1L8|RM14_HUMAN",1882,"Q6P1L8","RM14_HUMAN","39S ribosomal protein L14, mitochondrial","14mt;RP-L14","MRPL14"]
["23.3657","23.0387","23.2081","23.3333",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;autophagosome maturation;autophagosome membrane docking;membrane organization;mucus secretion;negative regulation of secretion by cell;neutrophil degranulation;positive regulation of histamine secretion by mast cell;post-Golgi vesicle-mediated transport;protein transport;regulation of protein localization to plasma membrane;vesicle fusion;viral entry into host cell","chloride channel inhibitor activity;SNAP receptor activity;SNARE binding","azurophil granule membrane;clathrin-coated vesicle membrane;cytoplasm;cytosol;early endosome;early endosome membrane;extracellular exosome;integral component of membrane;late endosome membrane;lysosomal membrane;membrane;mucin granule;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;recycling endosome;recycling endosome membrane;secretory granule membrane;SNARE complex;specific granule membrane;synaptic vesicle;tertiary granule membrane;vesicle","Autophagy - animal;Platelet activation;SNARE interactions in vesicular transport",null,null,7,7,7,55,55,55,"11.438",0,"41.47",623380000,35,"0.134698","0.894842","-0.0685148","-0.391292","sp|Q9BV40|VAMP8_HUMAN;tr|B8ZZT4|B8ZZT4_HUMAN;tr|C9JXZ5|C9JXZ5_HUMAN","sp|Q9BV40|VAMP8_HUMAN;tr|B8ZZT4|B8ZZT4_HUMAN",2465,"Q9BV40","VAMP8_HUMAN","Vesicle-associated membrane protein 8 {ECO:0000303|PubMed:12130530}","AMP-8 {ECO:0000303|PubMed:12130530}","VAMP8"]
["14.8175","14.1662","15.3434","13.78",{"$nulls":3},"cell migration;clathrin coat assembly;endocytosis;epidermal growth factor receptor signaling pathway;exocytosis;insulin receptor signaling pathway;membrane organization;phosphatidylinositol 3-kinase signaling;phosphatidylinositol biosynthetic process;platelet-derived growth factor receptor signaling pathway;vascular smooth muscle contraction","1-phosphatidylinositol-3-kinase activity;1-phosphatidylinositol-4-phosphate 3-kinase activity;ATP binding;phosphatidylinositol 3-kinase activity;phosphatidylinositol binding","clathrin-coated vesicle;cytoplasm;cytosol;extracellular exosome;Golgi apparatus;membrane;nucleus;phosphatidylinositol 3-kinase complex;plasma membrane;vesicle","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,2,2,2,"1.7","1.7","1.7","190.68","0.0011086","2.7177",30252000,5,"0.0260377","0.967143","-0.0698056","-0.082436","sp|O00443|P3C2A_HUMAN","sp|O00443|P3C2A_HUMAN",143,"O00443","P3C2A_HUMAN","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha","I3K-C2-alpha;tdIns-3-kinase C2 subunit alpha","PIK3C2A"]
["18.5341","18.9321","19.2286","18.3777",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell cycle arrest;cell migration;cell projection organization;COPII vesicle coating;embryonic cleavage;ER to Golgi vesicle-mediated transport;fibroblast apoptotic process;G1/S transition of mitotic cell cycle;gastrulation;integrin-mediated signaling pathway;intrinsic apoptotic signaling pathway;liver morphogenesis;MAPK cascade;mitotic metaphase plate congression;negative regulation of canonical Wnt signaling pathway;negative regulation of Rho protein signal transduction;negative regulation of transcription from RNA polymerase II promoter;nuclear protein quality control by the ubiquitin-proteasome system;positive regulation of cell proliferation;positive regulation of cytokinesis;positive regulation of mitotic metaphase/anaphase transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein monoubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;stem cell division;stress fiber assembly;trophectodermal cellular morphogenesis;ubiquitin-dependent protein catabolic process;Wnt signaling pathway","cyclin binding;Notch binding;POZ domain binding;protein heterodimerization activity;protein homodimerization activity;ubiquitin protein ligase binding","Cul3-RING ubiquitin ligase complex;cytosol;extracellular exosome;Golgi membrane;membrane;nucleoplasm;polar microtubule","Hedgehog signaling pathway;Ubiquitin mediated proteolysis",null,null,7,7,7,"10.3","10.3","10.3","88.929",0,"25.896",183870000,19,"0.0481023","0.954698","-0.0700293","-0.149097","sp|Q13618|CUL3_HUMAN;tr|A0A087WTG3|A0A087WTG3_HUMAN;tr|H7C399|H7C399_HUMAN;tr|A0A087X1R9|A0A087X1R9_HUMAN;tr|H7C1L6|H7C1L6_HUMAN","sp|Q13618|CUL3_HUMAN;tr|A0A087WTG3|A0A087WTG3_HUMAN",1579,"Q13618","CUL3_HUMAN","Cullin-3","UL-3","CUL3"]
["21.2303","21.2813","20.8949","21.7568",{"$nulls":3},"adenine salvage;central nervous system neuron development;cerebral cortex neuron differentiation;cytolysis;dendrite morphogenesis;dopamine metabolic process;GMP catabolic process;grooming behavior;guanine salvage;hypoxanthine metabolic process;hypoxanthine salvage;IMP metabolic process;IMP salvage;locomotory behavior;lymphocyte proliferation;positive regulation of dopamine metabolic process;protein homotetramerization;purine nucleotide biosynthetic process;purine ribonucleoside salvage;purine-containing compound salvage;response to amphetamine;striatum development","guanine phosphoribosyltransferase activity;hypoxanthine phosphoribosyltransferase activity;identical protein binding;magnesium ion binding;nucleotide binding;protein homodimerization activity","cytoplasm;cytosol;extracellular exosome","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism",null,null,4,4,4,"25.2","25.2","25.2","24.579",0,"21.352",364930000,14,"0.0525479","0.949057","-0.0700321","-0.162224","sp|P00492|HPRT_HUMAN","sp|P00492|HPRT_HUMAN",470,"P00492","HPRT_HUMAN","Hypoxanthine-guanine phosphoribosyltransferase","GPRT;GPRTase","HPRT1"]
["21.8608","21.6849","21.65","22.036",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of neuron death;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein folding;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent ERAD pathway;Wnt signaling pathway, planar cell polarity pathway","ATP binding;ATPase activity;proteasome-activating ATPase activity;RNA binding;TBP-class protein binding","cytosol;cytosolic proteasome complex;membrane;nuclear proteasome complex;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, base subcomplex","Epstein-Barr virus infection;Human papillomavirus infection;Proteasome;Viral carcinogenesis",null,null,12,12,12,"36.6","36.6","36.6","49.184",0,"122.77",1090200000,39,"0.112249","0.904592","-0.0701571","-0.3308","sp|P62191|PRS4_HUMAN;tr|G3V4X1|G3V4X1_HUMAN","sp|P62191|PRS4_HUMAN",1290,"P62191","PRS4_HUMAN","26S proteasome regulatory subunit 4","26s4","PSMC1"]
["19.2879","18.3437","19.1215","18.6505",{"$nulls":3},"ATP metabolic process;dATP metabolic process;dGDP biosynthetic process;dGMP metabolic process;GDP biosynthetic process;GDP-mannose metabolic process;glycoprotein transport;nucleobase-containing small molecule interconversion;purine nucleotide metabolic process","ATP binding;guanylate kinase activity","cytosol","Metabolic pathways;Purine metabolism",null,null,3,3,3,"16.2","16.2","16.2","21.725",0,"5.5142",76810000,5,"0.0427203","0.954825","-0.0702038","-0.133074","sp|Q16774|KGUA_HUMAN;tr|B1ANH5|B1ANH5_HUMAN;tr|B1ANH0|B1ANH0_HUMAN;tr|B1ANG9|B1ANG9_HUMAN;tr|B1ANH6|B1ANH6_HUMAN;tr|B1ANH2|B1ANH2_HUMAN;tr|B1ANH3|B1ANH3_HUMAN","sp|Q16774|KGUA_HUMAN;tr|B1ANH5|B1ANH5_HUMAN;tr|B1ANH0|B1ANH0_HUMAN;tr|B1ANG9|B1ANG9_HUMAN;tr|B1ANH6|B1ANH6_HUMAN;tr|B1ANH2|B1ANH2_HUMAN",1755,"Q16774","KGUA_HUMAN","Guanylate kinase",null,"GUK1"]
["21.6343","21.1262","21.8256","21.0754",{"$nulls":3},"defense response to bacterium;embryo development;endocytic recycling;fibroblast growth factor receptor signaling pathway;Golgi to endosome transport;intracellular transport;neutrophil degranulation;phagosome maturation;phosphatidylinositol biosynthetic process;protein transport;regulation of endocytosis;regulation of protein localization;vesicle-mediated transport","GDP binding;GTP binding;GTPase activity;myosin V binding","cytosol;early endosome;early endosome membrane;extracellular exosome;Golgi membrane;Golgi stack;intracellular;intracellular membrane-bounded organelle;late endosome;lysosomal membrane;lysosome;nuclear outer membrane-endoplasmic reticulum membrane network;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;recycling endosome;recycling endosome membrane;rough endoplasmic reticulum;tertiary granule membrane;trans-Golgi network;trans-Golgi network transport vesicle","AMPK signaling pathway",null,null,6,6,6,"41.9","41.9","41.9","23.897",0,"11.906",438690000,25,"0.0501446","0.950532","-0.0702868","-0.155139","sp|P61106|RAB14_HUMAN;tr|X6RFL8|X6RFL8_HUMAN","sp|P61106|RAB14_HUMAN;tr|X6RFL8|X6RFL8_HUMAN",1258,"P61106","RAB14_HUMAN","Ras-related protein Rab-14",null,"RAB14"]
["19.2293","19.3193","19.7245","18.9652",{"$nulls":3},"chaperone-mediated protein folding;protein folding","FK506 binding;heat shock protein binding;peptidyl-prolyl cis-trans isomerase activity","cytoplasm;cytosol;extracellular exosome;membrane;nucleoplasm","Estrogen signaling pathway",null,null,3,3,3,"9.8","9.8","9.8","51.212",0,"22.223",154330000,13,"0.0601559","0.944434","-0.0705252","-0.184477","sp|Q13451|FKBP5_HUMAN","sp|Q13451|FKBP5_HUMAN",1559,"Q13451","FKBP5_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP5","PIase FKBP5","FKBP5"]
["22.4683","21.6481","22.3722","21.8853",{"$nulls":3},"ADP biosynthetic process;AMP metabolic process;ATP metabolic process","adenylate kinase activity;ATP binding","mitochondrial intermembrane space",{"$nulls":3},8,8,8,"49.6","49.6","49.6","25.63",0,"17.685",618280000,24,"0.047712","0.954596","-0.0705566","-0.147939","tr|F8W1A4|F8W1A4_HUMAN;sp|P54819|KAD2_HUMAN;tr|F8VY04|F8VY04_HUMAN;tr|F8VZG5|F8VZG5_HUMAN;tr|G3V213|G3V213_HUMAN;tr|F8VPP1|F8VPP1_HUMAN","tr|F8W1A4|F8W1A4_HUMAN;sp|P54819|KAD2_HUMAN;tr|F8VY04|F8VY04_HUMAN;tr|F8VZG5|F8VZG5_HUMAN;tr|G3V213|G3V213_HUMAN",1197,"F8W1A4","F8W1A4_HUMAN","Adenylate kinase 2, mitochondrial {ECO:0000256|HAMAP-Rule:MF_03168}","K 2 {ECO:0000256|HAMAP-Rule:MF_03168}"]
["24.5702","24.4707","24.7877","24.3949",{"$nulls":3},"cellular response to leukemia inhibitory factor;chromosome segregation;negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of cell proliferation;regulation of insulin secretion;transport;viral process","adenine transmembrane transporter activity;ATP:ADP antiporter activity;RNA binding;ubiquitin protein ligase binding","extracellular exosome;extracellular matrix;integral component of plasma membrane;membrane;membrane raft;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrion;MMXD complex;myelin sheath;nucleus","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Necroptosis;Parkinson disease",null,null,8,8,3,"27.2","27.2","11.7","32.852",0,"33.947",4662700000,62,"0.119262","0.903074","-0.0708761","-0.349834","sp|P05141|ADT2_HUMAN;sp|Q9H0C2|ADT4_HUMAN","sp|P05141|ADT2_HUMAN",513,"P05141","ADT2_HUMAN","ADP/ATP translocase 2",null,"SLC25A5"]
["19.3433",1,"19.4851",1,{"$nulls":4},"DNA binding transcription factor activity",{"$nulls":4},1,1,1,"8.6","8.6","8.6","11.354","0.0014094","2.3148",26274000,3,"0.00167518","0.995394","-0.0708923","-0.0054445","tr|M0R0X9|M0R0X9_HUMAN;tr|M0QXC8|M0QXC8_HUMAN;tr|M0QYT9|M0QYT9_HUMAN;tr|M0R205|M0R205_HUMAN;tr|M0QZB8|M0QZB8_HUMAN;tr|M0QZB7|M0QZB7_HUMAN;sp|Q14653|IRF3_HUMAN","tr|M0R0X9|M0R0X9_HUMAN;tr|M0QXC8|M0QXC8_HUMAN;tr|M0QYT9|M0QYT9_HUMAN;tr|M0R205|M0R205_HUMAN;tr|M0QZB8|M0QZB8_HUMAN;tr|M0QZB7|M0QZB7_HUMAN;sp|Q14653|IRF3_HUMAN",1633,"M0R0X9","M0R0X9_HUMAN",null,null,"IRF3"]
["20.0629","20.2626","20.0622","20.4051",{"$nulls":3},"signal transduction","GTP binding;GTPase activity","membrane",{"$nulls":3},1,1,1,"7.2","7.2","7.2","19.569",0,"94.018",131380000,8,"0.122104","0.902265","-0.0709257","-0.357512","tr|E9PK85|E9PK85_HUMAN;tr|A0A0C4DGH2|A0A0C4DGH2_HUMAN;sp|P62070|RRAS2_HUMAN","tr|E9PK85|E9PK85_HUMAN;tr|A0A0C4DGH2|A0A0C4DGH2_HUMAN;sp|P62070|RRAS2_HUMAN",1287,"E9PK85","E9PK85_HUMAN",null,null,"RRAS2"]
["19.11","19.1006","19.7007","18.6527",{"$nulls":3},"asparaginyl-tRNA aminoacylation;tRNA aminoacylation for protein translation","asparagine-tRNA ligase activity;ATP binding;nucleic acid binding","cytoplasm;cytosol;extracellular exosome;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,4,4,4,12,12,12,"62.942",0,"8.7658",117900000,18,"0.0437967","0.954925","-0.0714197","-0.13629","sp|O43776|SYNC_HUMAN;tr|K7EJ19|K7EJ19_HUMAN;tr|K7EIU7|K7EIU7_HUMAN;tr|K7EQ35|K7EQ35_HUMAN;tr|K7EPK2|K7EPK2_HUMAN","sp|O43776|SYNC_HUMAN;tr|K7EJ19|K7EJ19_HUMAN;tr|K7EIU7|K7EIU7_HUMAN;tr|K7EQ35|K7EQ35_HUMAN",266,"O43776","SYNC_HUMAN","Asparagine--tRNA ligase, cytoplasmic",null,"NARS"]
[1,"19.7593",1,"19.9032",{"$nulls":9},1,1,1,"13.1","13.1","13.1","9.3216","0.003097","2.1039",15123000,0,"0.00166245","0.995219","-0.0719481","-0.00540321","tr|E9PKF1|E9PKF1_HUMAN;tr|E9PI70|E9PI70_HUMAN;tr|E9PIP0|E9PIP0_HUMAN;tr|E9PRL3|E9PRL3_HUMAN;tr|E9PPH0|E9PPH0_HUMAN;tr|E9PPA0|E9PPA0_HUMAN;sp|Q9BWS9|CHID1_HUMAN","tr|E9PKF1|E9PKF1_HUMAN;tr|E9PI70|E9PI70_HUMAN;tr|E9PIP0|E9PIP0_HUMAN;tr|E9PRL3|E9PRL3_HUMAN;tr|E9PPH0|E9PPH0_HUMAN;tr|E9PPA0|E9PPA0_HUMAN;sp|Q9BWS9|CHID1_HUMAN",2488,"E9PKF1","E9PKF1_HUMAN",null,null,"CHID1"]
["24.5339","24.2982","24.8687","24.109",{"$nulls":3},"mRNA splicing, via spliceosome;negative regulation of apoptotic process;negative regulation of mRNA splicing, via spliceosome;positive regulation of low-density lipoprotein particle receptor biosynthetic process;positive regulation of receptor-mediated endocytosis;positive regulation of transcription from RNA polymerase II promoter;regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter;regulation of low-density lipoprotein particle clearance;RNA metabolic process;RNA processing;signal transduction;viral process","cadherin binding;identical protein binding;protein domain specific binding;RNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;single-stranded DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","catalytic step 2 spliceosome;cell projection;cytoplasm;extracellular exosome;extracellular matrix;focal adhesion;membrane;nuclear chromatin;nucleoplasm;nucleus;podosome","MicroRNAs in cancer;Spliceosome;Viral carcinogenesis",null,null,21,21,21,"52.5","52.5","52.5","50.976",0,"323.31",4590500000,179,"0.0596796","0.944569","-0.0728168","-0.183092","sp|P61978|HNRPK_HUMAN;tr|Q5T6W2|Q5T6W2_HUMAN;tr|S4R457|S4R457_HUMAN;tr|S4R359|S4R359_HUMAN","sp|P61978|HNRPK_HUMAN;tr|Q5T6W2|Q5T6W2_HUMAN",1285,"P61978","HNRPK_HUMAN","Heterogeneous nuclear ribonucleoprotein K","nRNP K","HNRNPK"]
["17.7046","18.0456","18.1943","17.7022",{"$nulls":3},"cell junction assembly;cell-matrix adhesion;focal adhesion assembly;integrin activation;integrin-mediated signaling pathway;protein localization to membrane;regulation of cell shape;substrate adhesion-dependent cell spreading;transforming growth factor beta receptor signaling pathway;Wnt signaling pathway","phosphatidylinositol-3,4,5-trisphosphate binding","cell cortex;cell surface;cytoplasm;cytosol;extrinsic component of cytoplasmic side of plasma membrane;filamentous actin;focal adhesion;I band;lamellipodium membrane;nucleoplasm;nucleus;stress fiber",{"$nulls":3},3,3,3,"9.1","9.1","9.1","77.86",0,"18.602",99397000,18,"0.08102","0.928787","-0.0731192","-0.244244","sp|Q96AC1|FERM2_HUMAN;tr|H0YJ34|H0YJ34_HUMAN;tr|G3V3J0|G3V3J0_HUMAN","sp|Q96AC1|FERM2_HUMAN;tr|H0YJ34|H0YJ34_HUMAN",2230,"Q96AC1","FERM2_HUMAN","Fermitin family homolog 2",null,"FERMT2"]
["19.8459","19.7899","20.432","19.3521",{"$nulls":3},"regulation of cell growth","opioid receptor activity","cytoplasm;membrane;nucleus",{"$nulls":3},8,8,8,"19.6","19.6","19.6","73.324",0,"135.78",219110000,45,"0.0440912","0.954741","-0.0741615","-0.137169","sp|Q9NZT2|OGFR_HUMAN;tr|A0A0A0MRN5|A0A0A0MRN5_HUMAN;tr|A0A087X028|A0A087X028_HUMAN","sp|Q9NZT2|OGFR_HUMAN;tr|A0A0A0MRN5|A0A0A0MRN5_HUMAN",2764,"Q9NZT2","OGFR_HUMAN","Opioid growth factor receptor","GFr","OGFR"]
["21.5286","21.3474","22.0495","20.9758",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stem cell differentiation;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent protein catabolic process;Wnt signaling pathway, planar cell polarity pathway","structural molecule activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, lid subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,12,12,12,"35.5","35.5","35.5","47.463",0,"133.76",800400000,46,"0.0440941","0.955092","-0.0746861","-0.137178","sp|O00231|PSD11_HUMAN;tr|J3QRY4|J3QRY4_HUMAN;tr|J3QS13|J3QS13_HUMAN","sp|O00231|PSD11_HUMAN;tr|J3QRY4|J3QRY4_HUMAN",127,"O00231","PSD11_HUMAN","26S proteasome non-ATPase regulatory subunit 11",null,"PSMD11"]
["19.3648","19.1553","19.7545","18.9158",{"$nulls":9},3,3,3,"12.2","12.2","12.2","45.935",0,"5.1366",153130000,10,"0.0564502","0.944646","-0.0750694","-0.173671","tr|E9PF19|E9PF19_HUMAN;sp|Q9Y4P3|TBL2_HUMAN;tr|Q96E41|Q96E41_HUMAN","tr|E9PF19|E9PF19_HUMAN;sp|Q9Y4P3|TBL2_HUMAN;tr|Q96E41|Q96E41_HUMAN",3005,"E9PF19","E9PF19_HUMAN",null,null,"TBL2"]
["19.0276","18.9143","19.4547","18.6374",{"$nulls":3},"activation of protein kinase activity;apoptotic process;cytoplasmic microtubule organization;protein autophosphorylation;regulation of apoptotic process;regulation of cell migration;regulation of focal adhesion assembly;regulation of mitotic cell cycle;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;cadherin binding;identical protein binding;protein homodimerization activity;protein serine/threonine kinase activity","cell leading edge;cytoplasm;extracellular exosome;perinuclear region of cytoplasm","Oocyte meiosis",null,null,11,11,11,"12.4","12.4","12.4","142.69",0,"40.73",406040000,40,"0.059314","0.944297","-0.0751028","-0.182027","sp|Q9H2G2|SLK_HUMAN","sp|Q9H2G2|SLK_HUMAN",2577,"Q9H2G2","SLK_HUMAN","STE20-like serine/threonine-protein kinase","SLK;TE20-like kinase","SLK"]
["16.6789","16.6227","17.447","16.005",{"$nulls":9},1,1,1,12,12,12,"17.397","0.00038685","3.0714",5969800,1,"0.0331392","0.963835","-0.0751734","-0.10418","tr|F8W0A2|F8W0A2_HUMAN;sp|Q8TB37|NUBPL_HUMAN","tr|F8W0A2|F8W0A2_HUMAN;sp|Q8TB37|NUBPL_HUMAN",2110,"F8W0A2","F8W0A2_HUMAN",null,null,"NUBPL"]
["17.944","18.064","18.3311","17.8277",{"$nulls":3},"activation of GTPase activity;cell cycle;intracellular protein transport;regulation of GTPase activity;regulation of vesicle fusion","GTPase activator activity;Rab GTPase binding;tubulin binding","centrosome;cytosol;endomembrane system;microtubule associated complex",{"$nulls":3},4,4,4,"4.2","4.2","4.2","121.74",0,"42.372",129460000,22,"0.0979004","0.916674","-0.0753946","-0.291417","sp|Q9Y3P9|RBGP1_HUMAN;tr|B5MCD9|B5MCD9_HUMAN","sp|Q9Y3P9|RBGP1_HUMAN",2988,"Q9Y3P9","RBGP1_HUMAN","Rab GTPase-activating protein 1",null,"RABGAP1"]
["20.2428","20.6625","20.4125","20.6443",{"$nulls":3},"mesoderm development;phagocytosis;positive regulation of skeletal muscle acetylcholine-gated channel clustering;protein folding;protein localization to cell surface;Wnt signaling pathway","identical protein binding;low-density lipoprotein particle receptor binding","endoplasmic reticulum;plasma membrane",{"$nulls":3},4,4,4,"24.4","24.4","24.4","26.076",0,"45.367",152310000,12,"0.10677","0.912483","-0.0757103","-0.315831","sp|Q14696|MESD_HUMAN;tr|H0YLI4|H0YLI4_HUMAN","sp|Q14696|MESD_HUMAN",1640,"Q14696","MESD_HUMAN","LRP chaperone MESD {ECO:0000305}",null,"MESD"]
["18.9337","19.0066","19.5901","18.5023",{"$nulls":3},"activation of MAPK activity;apoptotic process;axon guidance;B cell receptor signaling pathway;Bergmann glial cell differentiation;cardiac neural crest cell development involved in heart development;caveolin-mediated endocytosis;cell cycle;cellular response to amino acid starvation;cellular response to cadmium ion;cellular response to DNA damage stimulus;cellular response to dopamine;cellular response to granulocyte macrophage colony-stimulating factor stimulus;cellular response to reactive oxygen species;cellular response to tumor necrosis factor;chemical synaptic transmission;chemotaxis;cytosine metabolic process;diadenosine tetraphosphate biosynthetic process;ERBB signaling pathway;ERK1 and ERK2 cascade;face development;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;fibroblast growth factor receptor signaling pathway;JAK-STAT cascade involved in growth hormone signaling pathway;labyrinthine layer blood vessel development;learning or memory;lipopolysaccharide-mediated signaling pathway;long-term synaptic potentiation;lung morphogenesis;mammary gland epithelial cell proliferation;MAPK cascade;negative regulation of cell differentiation;neutrophil degranulation;outer ear morphogenesis;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;platelet activation;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of gene expression;positive regulation of peptidyl-threonine phosphorylation;positive regulation of protein import into nucleus, translocation;positive regulation of telomerase activity;positive regulation of telomere capping;positive regulation of telomere maintenance via telomerase;positive regulation of transcription, DNA-templated;positive regulation of translation;protein phosphorylation;regulation of cellular pH;regulation of cellular response to heat;regulation of cytoskeleton organization;regulation of DNA binding transcription factor activity;regulation of early endosome to late endosome transport;regulation of Golgi inheritance;regulation of ossification;regulation of phosphatidylinositol 3-kinase signaling;regulation of protein stability;regulation of stress-activated MAPK cascade;response to epidermal growth factor;response to estrogen;response to exogenous dsRNA;response to nicotine;response to stress;response to toxic substance;sensory perception of pain;signal transduction;stress-activated MAPK cascade;T cell receptor signaling pathway;thymus development;thyroid gland development;trachea formation;transcription, DNA-templated;viral process","ATP binding;DNA binding;identical protein binding;kinase activity;MAP kinase activity;MAP kinase kinase activity;mitogen-activated protein kinase kinase kinase binding;phosphatase binding;phosphotyrosine residue binding;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity;transcription factor binding","axon;azurophil granule lumen;caveola;cytoplasm;cytoskeleton;cytosol;dendrite cytoplasm;early endosome;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;Golgi apparatus;late endosome;microtubule organizing center;mitochondrion;mitotic spindle;nucleoplasm;nucleus;perikaryon;plasma membrane;protein complex;pseudopodium","Acute myeloid leukemia;Adherens junction;Adrenergic signaling in cardiomyocytes;AGE-RAGE signaling pathway in diabetic complications;Alcoholism;Aldosterone-regulated sodium reabsorption;Alzheimer disease;Apelin signaling pathway;Apoptosis;Autophagy - animal;Axon guidance;B cell receptor signaling pathway;Bladder cancer;Breast cancer;cAMP signaling pathway;Cellular senescence;Central carbon metabolism in cancer;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Circadian entrainment;Colorectal cancer;C-type lectin receptor signaling pathway;Cushing syndrome;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Focal adhesion;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;Glutamatergic synapse;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;IL-17 signaling pathway;Influenza A;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;MicroRNAs in cancer;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Non-small cell lung cancer;Oocyte meiosis;Osteoclast differentiation;Oxytocin signaling pathway;Pancreatic cancer;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Pertussis;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Platelet activation;Platinum drug resistance;Prion diseases;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Retrograde endocannabinoid signaling;Salmonella infection;Serotonergic synapse;Shigellosis;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;TGF-beta signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid cancer;Thyroid hormone signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;Type II diabetes mellitus;Vascular smooth muscle contraction;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,7,7,5,"25.3","25.3","18.3","41.389",0,"16.345",145280000,20,"0.0448437","0.956162","-0.0759983","-0.139413","sp|P28482|MK01_HUMAN","sp|P28482|MK01_HUMAN",839,"P28482","MK01_HUMAN","Mitogen-activated protein kinase 1","AP kinase 1;APK 1","MAPK1"]
["25.4723","25.4936","26.1312","24.9869",{"$nulls":3},"membrane organization;negative regulation of ion transmembrane transport;negative regulation of transcription, DNA-templated;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein targeting;small GTPase mediated signal transduction;substantia nigra development","14-3-3 protein binding;identical protein binding;ion channel binding;protein C-terminus binding;protein domain specific binding;protein N-terminus binding","cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;focal adhesion;membrane;mitochondrion;protein complex","Cell cycle;Hepatitis B;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;Pathogenic Escherichia coli infection;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,12,8,8,"48.2","40.4","40.4","27.764",0,"323.31",6645700000,72,"0.0426715","0.954475","-0.0760689","-0.132928","sp|P27348|1433T_HUMAN;tr|E9PG15|E9PG15_HUMAN","sp|P27348|1433T_HUMAN;tr|E9PG15|E9PG15_HUMAN",820,"P27348","1433T_HUMAN","14-3-3 protein theta",null,"YWHAQ"]
["18.9883","18.9639","19.2645","18.84",{"$nulls":3},"fatty acid biosynthetic process","3-hydroxy-arachidoyl-CoA dehydratase activity;3-hydroxy-behenoyl-CoA dehydratase activity;3-hydroxy-lignoceroyl-CoA dehydratase activity;very-long-chain 3-hydroxyacyl-CoA dehydratase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;mitochondrion;nuclear membrane",{"$nulls":3},2,2,2,"6.5","6.5","6.5","40.069","0.00038941","3.1204",72135000,4,"0.122329","0.902409","-0.0761356","-0.358119","tr|H3BPZ1|H3BPZ1_HUMAN;sp|Q9P035|HACD3_HUMAN;tr|H3BS72|H3BS72_HUMAN;tr|H3BMZ1|H3BMZ1_HUMAN;tr|H3BRL8|H3BRL8_HUMAN","tr|H3BPZ1|H3BPZ1_HUMAN;sp|Q9P035|HACD3_HUMAN;tr|H3BS72|H3BS72_HUMAN;tr|H3BMZ1|H3BMZ1_HUMAN;tr|H3BRL8|H3BRL8_HUMAN",2769,"H3BPZ1","H3BPZ1_HUMAN","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase {ECO:0000256|RuleBase:RU363109}",null,"HACD3"]
["19.1024","18.6828","19.292","18.649",{"$nulls":3},"canonical glycolysis;fructose 6-phosphate metabolic process;glucose homeostasis;glycogen catabolic process;glycolysis from storage polysaccharide through glucose-1-phosphate;glycolytic process;glycolytic process through fructose-6-phosphate;muscle cell cellular homeostasis;positive regulation of insulin secretion;positive regulation of transcription from RNA polymerase II promoter;protein oligomerization","6-phosphofructokinase activity;ATP binding;fructose binding;identical protein binding;kinase binding;metal ion binding;protein C-terminus binding;protein homodimerization activity","6-phosphofructokinase complex;apical plasma membrane;cytosol;extracellular exosome;nucleus;sperm principal piece","AMPK signaling pathway;Biosynthesis of amino acids;Carbon metabolism;Central carbon metabolism in cancer;Fructose and mannose metabolism;Galactose metabolism;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Pentose phosphate pathway;RNA degradation",null,null,7,6,6,"12.8","11.7","11.7","85.182",0,"12.272",190170000,18,"0.0665105","0.935312","-0.0778761","-0.202868","sp|P08237|PFKAM_HUMAN;tr|F8VX13|F8VX13_HUMAN;tr|F8VNX2|F8VNX2_HUMAN;tr|F8VZQ1|F8VZQ1_HUMAN;tr|F8VP00|F8VP00_HUMAN;tr|F8W1J8|F8W1J8_HUMAN;tr|F8VSF7|F8VSF7_HUMAN;tr|F8VW30|F8VW30_HUMAN;tr|F8VSL1|F8VSL1_HUMAN;tr|F8VUB8|F8VUB8_HUMAN;tr|F8VYK8|F8VYK8_HUMAN;tr|F8VTQ3|F8VTQ3_HUMAN;tr|F8VZI0|F8VZI0_HUMAN;tr|F8VVE3|F8VVE3_HUMAN","sp|P08237|PFKAM_HUMAN",558,"P08237","PFKAM_HUMAN","ATP-dependent 6-phosphofructokinase, muscle type {ECO:0000255|HAMAP-Rule:MF_03184}","FK-M;TP-PFK {ECO:0000255|HAMAP-Rule:MF_03184}","PFKM"]
["20.9967","20.7895","21.0682","20.8761",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA processing;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;negative regulation of protein ubiquitination;positive regulation of protein targeting to mitochondrion;positive regulation of RNA splicing;regulation of autophagy of mitochondrion;RNA export from nucleus;termination of RNA polymerase II transcription","C2H2 zinc finger domain binding;enzyme binding;poly-pyrimidine tract binding;pre-mRNA 3'-splice site binding;RNA binding","commitment complex;nuclear speck;nucleoplasm;nucleus;spliceosomal complex;U2AF;U2-type prespliceosome","Spliceosome",null,null,5,5,5,"22.5","22.5","22.5","53.5",0,"103.34",222950000,26,"0.199331","0.821031","-0.0790701","-0.559831","sp|P26368|U2AF2_HUMAN;tr|K7ENG2|K7ENG2_HUMAN;tr|K7ELP8|K7ELP8_HUMAN","sp|P26368|U2AF2_HUMAN;tr|K7ENG2|K7ENG2_HUMAN",809,"P26368","U2AF2_HUMAN","Splicing factor U2AF 65 kDa subunit",null,"U2AF2"]
["17.3497","17.6573","17.3144","17.8515",{"$nulls":3},"androgen receptor signaling pathway;atrial cardiac muscle cell development;heart trabecula formation;negative regulation of apoptotic process;negative regulation of transcription from RNA polymerase II promoter;osteoblast differentiation;positive regulation of transcription, DNA-templated;regulation of lipid metabolic process;response to hormone;transcription, DNA-templated;ventricular cardiac muscle cell development","androgen receptor binding;identical protein binding;metal ion binding;transcription coactivator activity;transcription factor binding","focal adhesion;M band;nucleoplasm;nucleus;Z disc","Osteoclast differentiation",null,null,1,1,1,"3.9","3.9","3.9","32.193","0.0047571","2.0042",41187000,6,"0.0854251","0.926521","-0.0794191","-0.256649","sp|Q14192|FHL2_HUMAN;tr|J3KNW4|J3KNW4_HUMAN;tr|A0A0A0MSG2|A0A0A0MSG2_HUMAN","sp|Q14192|FHL2_HUMAN;tr|J3KNW4|J3KNW4_HUMAN;tr|A0A0A0MSG2|A0A0A0MSG2_HUMAN",1609,"Q14192","FHL2_HUMAN","Four and a half LIM domains protein 2","HL-2","FHL2"]
["18.0432","18.2919","18.1202","18.3763",{"$nulls":3},"canonical glycolysis;glucose metabolic process","ADP-specific glucokinase activity;metal ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular region;membrane","Carbon metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways",null,null,1,1,1,3,3,3,"54.088",0,"3.879",54848000,4,"0.157797","0.868183","-0.0807152","-0.452345","sp|Q9BRR6|ADPGK_HUMAN","sp|Q9BRR6|ADPGK_HUMAN",2430,"Q9BRR6","ADPGK_HUMAN","ADP-dependent glucokinase","DPGK;DP-GK","ADPGK"]
["21.403","21.1185","21.6762","21.0081",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;blastocyst development;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;proteolysis;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent ERAD pathway;Wnt signaling pathway, planar cell polarity pathway","ATP binding;ATPase activity;proteasome-activating ATPase activity;TBP-class protein binding","cytosol;cytosolic proteasome complex;inclusion body;membrane;nuclear proteasome complex;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, base subcomplex;synapse","Epstein-Barr virus infection;Proteasome",null,null,11,11,11,"54.8","54.8","54.8","47.366",0,"213.45",678890000,49,"0.0740004","0.931241","-0.0814486","-0.224329","sp|P43686|PRS6B_HUMAN","sp|P43686|PRS6B_HUMAN",1014,"P43686","PRS6B_HUMAN","26S proteasome regulatory subunit 6B",null,"PSMC4"]
["21.0624","20.3939","21.133","20.4871",{"$nulls":9},6,6,6,"17.1","17.1","17.1","51.41",0,"11.29",417230000,22,"0.0572758","0.944048","-0.0818377","-0.176084","tr|F8VS02|F8VS02_HUMAN;sp|P49419|AL7A1_HUMAN;tr|A0A0J9YWF7|A0A0J9YWF7_HUMAN;tr|H0YHM6|H0YHM6_HUMAN;tr|F8VVF2|F8VVF2_HUMAN;tr|A0A0J9YWM6|A0A0J9YWM6_HUMAN;tr|F8WDY6|F8WDY6_HUMAN;tr|F8WD33|F8WD33_HUMAN","tr|F8VS02|F8VS02_HUMAN;sp|P49419|AL7A1_HUMAN;tr|A0A0J9YWF7|A0A0J9YWF7_HUMAN;tr|H0YHM6|H0YHM6_HUMAN",1078,"F8VS02"]
["23.4428","23.3372","23.9684","22.9757",{"$nulls":3},"antigen processing and presentation;axonogenesis;cellular response to insulin stimulus;endoplasmic reticulum tubular network organization;endosomal transport;establishment of neuroblast polarity;establishment of protein localization to endoplasmic reticulum membrane;establishment of protein localization to membrane;Golgi to plasma membrane protein transport;Golgi to plasma membrane transport;neutrophil degranulation;polarized epithelial cell differentiation;protein localization to basolateral plasma membrane;protein localization to plasma membrane;protein secretion;regulation of exocytosis;vesicle docking involved in exocytosis;vesicle-mediated transport","cadherin binding involved in cell-cell adhesion;GDP binding;GTP binding;GTPase activity;myosin V binding","cell-cell adherens junction;cilium;cytoplasmic vesicle membrane;cytosol;endoplasmic reticulum membrane;endoplasmic reticulum tubular network;endosome;exocytic vesicle;extracellular exosome;focal adhesion;Golgi apparatus;Golgi membrane;insulin-responsive compartment;phagocytic vesicle membrane;plasma membrane;recycling endosome;recycling endosome membrane;secretory granule membrane;trans-Golgi network","AMPK signaling pathway;Endocytosis",null,null,5,5,4,28,28,"24.5","22.541",0,"60.741",1265200000,41,"0.0533094","0.947699","-0.0820942","-0.164463","sp|P61026|RAB10_HUMAN","sp|P61026|RAB10_HUMAN",1254,"P61026","RAB10_HUMAN","Ras-related protein Rab-10",null,"RAB10"]
["19.2295","19.1795","19.247","19.3269",{"$nulls":3},"branching involved in ureteric bud morphogenesis;cell aging;cell cycle arrest;cell junction assembly;cell proliferation;cell-matrix adhesion;establishment or maintenance of epithelial cell apical/basal polarity;fibroblast migration;integrin-mediated signaling pathway;MAPK cascade;multicellular organism development;myelin assembly;myelination in peripheral nervous system;negative regulation of cardiac muscle cell apoptotic process;negative regulation of neural precursor cell proliferation;negative regulation of neuron apoptotic process;negative regulation of protein kinase activity;negative regulation of smooth muscle cell migration;negative regulation of smooth muscle cell proliferation;nerve development;neuron projection morphogenesis;outflow tract morphogenesis;peptidyl-serine phosphorylation;platelet aggregation;positive regulation of axon extension;positive regulation of BMP signaling pathway;positive regulation of canonical Wnt signaling pathway;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of cell-matrix adhesion;positive regulation of dendrite morphogenesis;positive regulation of MAP kinase activity;positive regulation of myoblast differentiation;positive regulation of NIK/NF-kappaB signaling;positive regulation of osteoblast differentiation;positive regulation of phosphorylation;positive regulation of protein kinase B signaling;positive regulation of transcription, DNA-templated;protein heterooligomerization;protein kinase B signaling;protein phosphorylation;regulation of actin cytoskeleton organization;substrate adhesion-dependent cell spreading;supramolecular fiber organization;tumor necrosis factor-mediated signaling pathway","ATP binding;integrin binding;protein kinase binding;protein serine/threonine kinase activity;SH3 domain binding;signal transducer activity","cell junction;cell-cell junction;costamere;cytoplasm;cytosol;dendritic shaft;focal adhesion;lamellipodium;membrane;neuronal cell body;nucleoplasm;plasma membrane;protein complex;sarcomere;stress fiber;terminal bouton","Axon guidance;Bacterial invasion of epithelial cells;Endometrial cancer;Focal adhesion;PPAR signaling pathway",null,null,5,5,5,"13.1","13.1","13.1","51.419",0,"9.9629",176860000,15,"0.652787","0.391732","-0.0824699","-1.74876","sp|Q13418|ILK_HUMAN;tr|A0A0A0MTH3|A0A0A0MTH3_HUMAN","sp|Q13418|ILK_HUMAN;tr|A0A0A0MTH3|A0A0A0MTH3_HUMAN",1550,"Q13418","ILK_HUMAN","Integrin-linked protein kinase",null,"ILK"]
["19.9543","20.6249","20.2007","20.5439",{"$nulls":3},"hemidesmosome assembly","actin binding;ankyrin binding;cadherin binding;RNA binding;structural constituent of muscle","brush border;costamere;cytosol;extracellular exosome;extracellular matrix;focal adhesion;hemidesmosome;intermediate filament cytoskeleton;plasma membrane;sarcolemma;sarcoplasm",{"$nulls":3},68,68,67,"19.4","19.4",19,"531.78",0,"323.31",3395800000,255,"0.0723272","0.931724","-0.0826912","-0.219555","sp|Q15149|PLEC_HUMAN;tr|E9PMV1|E9PMV1_HUMAN;tr|H0YDN1|H0YDN1_HUMAN;tr|E9PQ28|E9PQ28_HUMAN;tr|E9PIA2|E9PIA2_HUMAN;tr|E9PKG0|E9PKG0_HUMAN","sp|Q15149|PLEC_HUMAN",1679,"Q15149","PLEC_HUMAN","Plectin","CN;LTN","PLEC"]
["16.9593","16.705","16.9492","16.882",{"$nulls":5},"nucleus",{"$nulls":3},1,1,1,"0.9","0.9","0.9","160.74",0,"11.441",67317000,8,"0.228678","0.794153","-0.083477","-0.634526","tr|F8VU51|F8VU51_HUMAN;sp|P49750|YLPM1_HUMAN","tr|F8VU51|F8VU51_HUMAN;sp|P49750|YLPM1_HUMAN",1090,"F8VU51","F8VU51_HUMAN",null,null,"YLPM1"]
["15.6325","15.5377","15.8068","15.5304",{"$nulls":3},"BMP signaling pathway;histone H2B conserved C-terminal lysine deubiquitination;monoubiquitinated protein deubiquitination;pathway-restricted SMAD protein phosphorylation;protein deubiquitination;transforming growth factor beta receptor signaling pathway;ubiquitin-dependent protein catabolic process","cysteine-type endopeptidase activity;identical protein binding;SMAD binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;transforming growth factor beta receptor binding;ubiquitin modification-dependent histone binding","cytoplasm;cytosol;mitochondrion;nucleus","Mitophagy - animal",null,null,2,2,2,"3.3","3.3","3.3","112.42",0,"3.9698",21945000,2,"0.204015","0.817769","-0.0835276","-0.571809","sp|Q9Y4E8|UBP15_HUMAN;tr|F8VZG8|F8VZG8_HUMAN;tr|F8W0H4|F8W0H4_HUMAN;tr|H0YI31|H0YI31_HUMAN","sp|Q9Y4E8|UBP15_HUMAN;tr|F8VZG8|F8VZG8_HUMAN;tr|F8W0H4|F8W0H4_HUMAN;tr|H0YI31|H0YI31_HUMAN",2997,"Q9Y4E8","UBP15_HUMAN","Ubiquitin carboxyl-terminal hydrolase 15",null,"USP15"]
["17.4799","16.7788","17.3811","17.0473",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"6.9","6.9","6.9","72.54",0,"4.6029",46150000,7,"0.0719704","0.931716","-0.0848484","-0.218535","tr|A0A0C4DFM1|A0A0C4DFM1_HUMAN;sp|Q92544|TM9S4_HUMAN","tr|A0A0C4DFM1|A0A0C4DFM1_HUMAN;sp|Q92544|TM9S4_HUMAN",2171,"A0A0C4DFM1","A0A0C4DFM1_HUMAN","Transmembrane 9 superfamily member {ECO:0000256|RuleBase:RU363079}"]
["22.5358","22.4715","22.2249","22.9531",{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},6,6,6,"30.4","30.4","30.4","29.667",0,"10.288",559200000,15,"0.0772671","0.931419","-0.0853891","-0.23362","tr|H0Y8G5|H0Y8G5_HUMAN;sp|Q14103|HNRPD_HUMAN;tr|H0YA96|H0YA96_HUMAN;tr|D6RAF8|D6RAF8_HUMAN;tr|D6RD83|D6RD83_HUMAN;tr|D6RF44|D6RF44_HUMAN;tr|D6RBQ9|D6RBQ9_HUMAN","tr|H0Y8G5|H0Y8G5_HUMAN;sp|Q14103|HNRPD_HUMAN;tr|H0YA96|H0YA96_HUMAN;tr|D6RAF8|D6RAF8_HUMAN;tr|D6RD83|D6RD83_HUMAN;tr|D6RF44|D6RF44_HUMAN",1599,"H0Y8G5","H0Y8G5_HUMAN",null,null,"HNRNPD"]
["19.5998","19.5759","19.9565","19.3919",{"$nulls":3},"negative regulation of blood pressure;peptide catabolic process;proteolysis","aminopeptidase activity;epoxide hydrolase activity;metalloaminopeptidase activity;metalloexopeptidase activity;peptide binding;zinc ion binding","extracellular exosome;extracellular region;plasma membrane;secretory granule",{"$nulls":3},6,6,6,"14.6","14.6","14.6","72.595",0,"67.256",270620000,31,"0.103062","0.915274","-0.0863562","-0.305655","sp|Q9H4A4|AMPB_HUMAN;tr|A6NKB8|A6NKB8_HUMAN;tr|C9JMZ3|C9JMZ3_HUMAN;tr|H7C2T3|H7C2T3_HUMAN;tr|A0A087WU27|A0A087WU27_HUMAN","sp|Q9H4A4|AMPB_HUMAN;tr|A6NKB8|A6NKB8_HUMAN",2596,"Q9H4A4","AMPB_HUMAN","Aminopeptidase B","P-B","RNPEP"]
["21.596","20.7374","21.3298","21.177",{"$nulls":3},"biosynthetic process","arylesterase activity;strictosidine synthase activity","cell surface;endoplasmic reticulum;extracellular exosome;integral component of membrane;membrane",{"$nulls":3},6,6,6,"20.9","20.9","20.9","46.48",0,"19.947",510830000,23,"0.0651272","0.937268","-0.0867252","-0.198879","sp|Q9HDC9|APMAP_HUMAN;tr|H0Y512|H0Y512_HUMAN","sp|Q9HDC9|APMAP_HUMAN;tr|H0Y512|H0Y512_HUMAN",2652,"Q9HDC9","APMAP_HUMAN","Adipocyte plasma membrane-associated protein",null,"APMAP"]
["18.7844","18.6511","18.9446","18.665",{"$nulls":3},"co-translational protein modification;glycoprotein catabolic process;post-translational protein modification;protein N-linked glycosylation via asparagine;response to unfolded protein;ubiquitin-dependent ERAD pathway","dolichyl-diphosphooligosaccharide-protein glycotransferase activity;metal ion binding","endoplasmic reticulum;integral component of membrane;membrane;oligosaccharyltransferase complex","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,5,5,5,"7.6","7.6","7.6","93.673",0,"35.707",144340000,21,"0.200168","0.821239","-0.0870447","-0.561972","sp|Q8TCJ2|STT3B_HUMAN","sp|Q8TCJ2|STT3B_HUMAN",2115,"Q8TCJ2","STT3B_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B","ligosaccharyl transferase subunit STT3B;TT3-B","STT3B"]
["16.4738","16.1362","16.399","16.3854",{"$nulls":3},"actin cytoskeleton reorganization;chemical synaptic transmission;dendrite morphogenesis;intracellular signal transduction;JNK cascade;multicellular organism development;neuron projection morphogenesis;positive regulation of JNK cascade;protein autophosphorylation;protein phosphorylation;regulation of AMPA receptor activity;regulation of apoptotic process;regulation of cell migration;regulation of cell-cell adhesion;regulation of cell-matrix adhesion;regulation of mitotic cell cycle;response to stress","ATP binding;MAP kinase kinase kinase kinase activity;protein kinase activity;protein serine/threonine kinase activity","axon;cell junction;cytoplasm;cytosol;dendrite;extracellular exosome;Golgi apparatus;postsynaptic density;postsynaptic membrane",{"$nulls":3},2,1,1,2,1,1,"149.82",0,"46.639",40660000,9,"0.182382","0.83522","-0.0871916","-0.516266","sp|Q8N4C8|MINK1_HUMAN;tr|C9J338|C9J338_HUMAN;tr|I3L2I2|I3L2I2_HUMAN","sp|Q8N4C8|MINK1_HUMAN;tr|C9J338|C9J338_HUMAN;tr|I3L2I2|I3L2I2_HUMAN",2049,"Q8N4C8","MINK1_HUMAN","Misshapen-like kinase 1",null,"MINK1"]
["18.6079","18.4635","19.1267","18.1192",{"$nulls":3},"amino acid transport;cognition;glutamine transport;hydroxyproline transport;L-alanine transport;L-cystine transport;L-serine transport;proline transport;synaptic transmission, glutamatergic;threonine transport","amino acid transmembrane transporter activity;chloride channel activity;L-alanine transmembrane transporter activity;L-cystine transmembrane transporter activity;L-glutamine transmembrane transporter activity;L-hydroxyproline transmembrane transporter activity;L-proline transmembrane transporter activity;L-serine transmembrane transporter activity;L-threonine transmembrane transporter activity;symporter activity","cell surface;dendrite;extracellular exosome;integral component of membrane;integral component of plasma membrane;intermediate filament;melanosome;membrane;neuronal cell body;plasma membrane",{"$nulls":3},2,2,2,"10.3","10.3","10.3","55.722","0.0011278","2.817",89747000,14,"0.0556938","0.944878","-0.0872574","-0.171458","sp|P43007|SATT_HUMAN","sp|P43007|SATT_HUMAN",1001,"P43007","SATT_HUMAN","Neutral amino acid transporter A",null,"SLC1A4"]
["18.6878","18.8599","19.4666","18.2564",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;cargo loading into COPII-coated vesicle;COPII vesicle coating;ER to Golgi vesicle-mediated transport;IRE1-mediated unfolded protein response;protein transport;response to calcium ion","calcium-dependent protein binding","COPII vesicle coat;COPII-coated ER to Golgi transport vesicle;cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum exit site;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane;intracellular membrane-bounded organelle;perinuclear region of cytoplasm;vesicle coat","Protein processing in endoplasmic reticulum",null,null,7,7,7,"8.6","8.6","8.6","133.01",0,"16.927",205890000,25,"0.0461988","0.955288","-0.0876665","-0.143446","sp|O94979|SC31A_HUMAN;tr|D6REX3|D6REX3_HUMAN;tr|D6RHZ5|D6RHZ5_HUMAN;tr|H7BXG7|H7BXG7_HUMAN;tr|H0YAB3|H0YAB3_HUMAN;tr|H0Y9K1|H0Y9K1_HUMAN;tr|H0Y8V7|H0Y8V7_HUMAN;tr|H0YAF5|H0YAF5_HUMAN;tr|H0Y9V3|H0Y9V3_HUMAN;tr|H0Y9T9|H0Y9T9_HUMAN;tr|H0Y8W8|H0Y8W8_HUMAN","sp|O94979|SC31A_HUMAN;tr|D6REX3|D6REX3_HUMAN;tr|D6RHZ5|D6RHZ5_HUMAN;tr|H7BXG7|H7BXG7_HUMAN",406,"O94979","SC31A_HUMAN","Protein transport protein Sec31A",null,"SEC31A"]
["19.698","19.5877","19.9625","19.4988",{"$nulls":3},"isoleucyl-tRNA aminoacylation;tRNA aminoacylation for protein translation","aminoacyl-tRNA editing activity;ATP binding;isoleucine-tRNA ligase activity;tRNA binding","cytosol;mitochondrial matrix;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,6,6,6,"6.9","6.9","6.9","113.79",0,"9.7461",309270000,16,"0.126151","0.898237","-0.0878077","-0.36841","sp|Q9NSE4|SYIM_HUMAN","sp|Q9NSE4|SYIM_HUMAN",2693,"Q9NSE4","SYIM_HUMAN","Isoleucine--tRNA ligase, mitochondrial",null,"IARS2"]
["16.8885","15.7365","16.5103","16.2926",{"$nulls":3},"peptidyl-lysine modification to peptidyl-hypusine",{"$nulls":5},2,2,2,"11.6","11.6","11.6","31.002","0.0003888","3.1125",17839000,4,"0.0490291","0.953046","-0.0890079","-0.151841","tr|Q5J8M5|Q5J8M5_HUMAN;sp|P49366|DHYS_HUMAN;tr|A0A087WZK0|A0A087WZK0_HUMAN;tr|M0R1T4|M0R1T4_HUMAN;tr|M0R253|M0R253_HUMAN;tr|M0QX43|M0QX43_HUMAN;tr|M0R1T2|M0R1T2_HUMAN;tr|B4E3M2|B4E3M2_HUMAN;tr|M0R0V2|M0R0V2_HUMAN;tr|M0R264|M0R264_HUMAN","tr|Q5J8M5|Q5J8M5_HUMAN;sp|P49366|DHYS_HUMAN;tr|A0A087WZK0|A0A087WZK0_HUMAN;tr|M0R1T4|M0R1T4_HUMAN;tr|M0R253|M0R253_HUMAN;tr|M0QX43|M0QX43_HUMAN;tr|M0R1T2|M0R1T2_HUMAN;tr|B4E3M2|B4E3M2_HUMAN;tr|M0R0V2|M0R0V2_HUMAN;tr|M0R264|M0R264_HUMAN",1073,"Q5J8M5","Q5J8M5_HUMAN",null,null,"DHPS"]
["22.6025","22.4592","22.9966","22.2437",{"$nulls":3},"neutrophil degranulation","serine-type endopeptidase inhibitor activity","extracellular exosome;extracellular matrix;extracellular region;extracellular space;membrane;secretory granule lumen",{"$nulls":3},9,9,9,28,28,28,"42.741",0,"72.09",1010800000,49,"0.0770075","0.931681","-0.0892487","-0.232884","sp|P30740|ILEU_HUMAN","sp|P30740|ILEU_HUMAN",877,"P30740","ILEU_HUMAN","Leukocyte elastase inhibitor","EI","SERPINB1"]
["21.8886","21.6314","22.2149","21.4867",{"$nulls":3},"cellular response to interferon-gamma;glutamyl-tRNA aminoacylation;negative regulation of translation;prolyl-tRNA aminoacylation;protein complex assembly;tRNA aminoacylation for protein translation","ATP binding;glutamate-tRNA ligase activity;GTPase binding;identical protein binding;proline-tRNA ligase activity;protein homodimerization activity;RNA stem-loop binding;zinc ion binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;GAIT complex;intracellular ribonucleoprotein complex;membrane","Aminoacyl-tRNA biosynthesis;Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,30,30,29,"26.3","26.3","25.7","170.59",0,"234.9",2994600000,149,"0.0778023","0.930839","-0.0907917","-0.235139","sp|P07814|SYEP_HUMAN;tr|V9GYZ6|V9GYZ6_HUMAN;tr|V9GZ76|V9GZ76_HUMAN","sp|P07814|SYEP_HUMAN;tr|V9GYZ6|V9GYZ6_HUMAN",548,"P07814","SYEP_HUMAN","Bifunctional glutamate/proline--tRNA ligase",null,"EPRS"]
["20.0387","19.2613","20.1503","19.3317",{"$nulls":3},"intracellular protein transport;regulation of macroautophagy;retrograde transport, endosome to Golgi;retrograde transport, endosome to plasma membrane;Wnt signaling pathway","protein transporter activity","cytosol;early endosome;endosome;endosome membrane;extracellular exosome;lysosome;retromer complex;retromer, cargo-selective complex;tubular endosome;vesicle","Endocytosis",null,null,4,4,3,"15.3","15.3","13.1","38.169",0,"6.8281",131160000,19,"0.052219","0.949075","-0.0910234","-0.161256","sp|O75436|VP26A_HUMAN;tr|S4R3Q6|S4R3Q6_HUMAN","sp|O75436|VP26A_HUMAN;tr|S4R3Q6|S4R3Q6_HUMAN",344,"O75436","VP26A_HUMAN","Vacuolar protein sorting-associated protein 26A",null,"VPS26A"]
["15.5449","15.4281","15.4702","15.6853",{"$nulls":3},"bone development;chaperone-mediated protein folding;collagen metabolic process;negative regulation of cell proliferation;negative regulation of post-translational protein modification;protein folding;protein hydroxylation;protein stabilization;regulation of protein secretion","iron ion binding;L-ascorbic acid binding;procollagen-proline 3-dioxygenase activity;protein complex binding","endoplasmic reticulum;endoplasmic reticulum lumen;extracellular exosome;macromolecular complex;membrane;proteinaceous extracellular matrix",{"$nulls":3},1,1,1,"1.6","1.6","1.6","83.393",0,"6.1338",14607000,2,"0.272846","0.755368","-0.0912709","-0.745814","sp|Q32P28|P3H1_HUMAN","sp|Q32P28|P3H1_HUMAN",1777,"Q32P28","P3H1_HUMAN","Prolyl 3-hydroxylase 1 {ECO:0000312|HGNC:HGNC:19316}",null,"P3H1"]
["15.6731","15.247","15.8832","15.2199",{"$nulls":3},"chromosome organization;inactivation of X chromosome by DNA methylation;nose development","ATP binding;ATPase activity","Barr body",{"$nulls":3},4,4,4,4,4,4,"226.37",0,"9.8384",51785000,7,"0.076714","0.930452","-0.0914679","-0.23205","sp|A6NHR9|SMHD1_HUMAN;tr|J3KTL8|J3KTL8_HUMAN;tr|J3QSH1|J3QSH1_HUMAN","sp|A6NHR9|SMHD1_HUMAN;tr|J3KTL8|J3KTL8_HUMAN",105,"A6NHR9","SMHD1_HUMAN","Structural maintenance of chromosomes flexible hinge domain-containing protein 1",null,"SMCHD1"]
["22.5476","22.6677","22.8217","22.5768",{"$nulls":3},"ATP biosynthetic process;cristae formation;mitochondrial ATP synthesis coupled proton transport;proton transport","ATPase activity;drug binding;proton-transporting ATP synthase activity, rotational mechanism;transmembrane transporter activity;transporter activity","extracellular exosome;extracellular matrix;mitochondrial inner membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrion;nucleus;plasma membrane","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,6,6,6,"39.9","39.9","39.9","23.277",0,"24.192",646430000,17,"0.243366","0.784384","-0.0916014","-0.671649","sp|P48047|ATPO_HUMAN;tr|H7C0C1|H7C0C1_HUMAN;tr|H7C086|H7C086_HUMAN;tr|H7C068|H7C068_HUMAN","sp|P48047|ATPO_HUMAN;tr|H7C0C1|H7C0C1_HUMAN",1049,"P48047","ATPO_HUMAN","ATP synthase subunit O, mitochondrial",null,"ATP5O"]
["21.3008","21.4839","21.5328","21.436",{"$nulls":3},"cornification;extracellular matrix disassembly;mammary gland involution;neutrophil degranulation;positive regulation of cell proliferation;proteolysis;receptor catabolic process;regulation of catalytic activity;regulation of macroautophagy;self proteolysis","calcium ion binding;calcium-dependent cysteine-type endopeptidase activity;endopeptidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;lysosome;membrane;mitochondrion;plasma membrane","Alzheimer disease;Apoptosis;Cellular senescence;Necroptosis;Protein processing in endoplasmic reticulum",null,null,14,14,14,"32.1","32.1","32.1","81.889",0,"102.48",994810000,52,"0.329863","0.702912","-0.0920439","-0.888807","sp|P07384|CAN1_HUMAN;tr|E9PL37|E9PL37_HUMAN;tr|E9PRM1|E9PRM1_HUMAN;tr|E9PLX0|E9PLX0_HUMAN;tr|E9PJJ3|E9PJJ3_HUMAN;tr|E9PLC9|E9PLC9_HUMAN;tr|E9PMC6|E9PMC6_HUMAN;tr|E9PJA6|E9PJA6_HUMAN;tr|E9PSA6|E9PSA6_HUMAN;tr|E9PQB3|E9PQB3_HUMAN;tr|E9PIA9|E9PIA9_HUMAN","sp|P07384|CAN1_HUMAN",543,"P07384","CAN1_HUMAN","Calpain-1 catalytic subunit {ECO:0000305}",null,"CAPN1"]
["16.315","16.1446","16.5643","16.0795",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;transcription from RNA polymerase III promoter;transcription, DNA-templated;tRNA transcription from RNA polymerase III promoter",null,"nucleoplasm;transcription factor TFIIIC complex",{"$nulls":3},2,2,2,"4.1","4.1","4.1","100.68","0.0097466","1.6723",21968000,2,"0.122502","0.902552","-0.0921278","-0.358586","sp|Q8WUA4|TF3C2_HUMAN;tr|H7C318|H7C318_HUMAN;tr|H0Y4Q6|H0Y4Q6_HUMAN;tr|A0A087WZD8|A0A087WZD8_HUMAN","sp|Q8WUA4|TF3C2_HUMAN;tr|H7C318|H7C318_HUMAN;tr|H0Y4Q6|H0Y4Q6_HUMAN;tr|A0A087WZD8|A0A087WZD8_HUMAN",2135,"Q8WUA4","TF3C2_HUMAN","General transcription factor 3C polypeptide 2",null,"GTF3C2"]
["15.6189","16.1038","16.8172","15.0899",{"$nulls":3},"apoptotic signaling pathway;transcription, DNA-templated","metal ion binding;RNA binding","cytoplasm;nucleus;spindle",{"$nulls":3},4,4,4,"2.7","2.7","2.7","243.87",0,"16.902",70584000,13,"0.0326868","0.963116","-0.0922155","-0.102803","sp|Q9BTC0|DIDO1_HUMAN","sp|Q9BTC0|DIDO1_HUMAN",2443,"Q9BTC0","DIDO1_HUMAN","Death-inducer obliterator 1","Dido1;IO-1","DIDO1"]
["23.5373","23.4316","23.5984","23.5551",{"$nulls":3},"apoptotic signaling pathway;calcium ion transport;ion transmembrane transport;mitochondrial calcium ion homeostasis;protein homooligomerization;regulation of muscle contraction","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;cholesterol binding;GTP binding;ligand-gated ion channel activity;lipid binding;protein homodimerization activity","extracellular exosome;focal adhesion;late endosome membrane;lysosomal membrane;melanosome;membrane;mitochondrion;perinuclear region of cytoplasm",{"$nulls":3},24,24,10,"42.5","42.5","17.4","75.872",0,"208.13",3612100000,128,"0.606487","0.428199","-0.092308","-1.61604","sp|P08133|ANXA6_HUMAN;tr|E7EMC6|E7EMC6_HUMAN;tr|E5RFF0|E5RFF0_HUMAN;tr|E5RI05|E5RI05_HUMAN;tr|E5RJF5|E5RJF5_HUMAN;tr|E5RK63|E5RK63_HUMAN;tr|H0YC77|H0YC77_HUMAN;tr|E5RIU8|E5RIU8_HUMAN;tr|E5RJR0|E5RJR0_HUMAN","sp|P08133|ANXA6_HUMAN;tr|E7EMC6|E7EMC6_HUMAN",555,"P08133","ANXA6_HUMAN","Annexin A6",null,"ANXA6"]
["24.0187","23.9066","24.6445","23.466",{"$nulls":3},"ephrin receptor signaling pathway;muscle contraction;platelet aggregation","calcium ion binding","cytosol;extracellular exosome;myosin complex","Axon guidance;Focal adhesion;Leukocyte transendothelial migration;Platelet activation;Regulation of actin cytoskeleton;Tight junction",null,null,7,7,7,"43.9","43.9","43.9","19.794",0,"97.578",1765500000,32,"0.0506004","0.949974","-0.0926247","-0.156485","sp|P19105|ML12A_HUMAN;sp|O14950|ML12B_HUMAN;tr|J3QRS3|J3QRS3_HUMAN;tr|J3KTJ1|J3KTJ1_HUMAN;sp|P24844|MYL9_HUMAN","sp|P19105|ML12A_HUMAN;sp|O14950|ML12B_HUMAN;tr|J3QRS3|J3QRS3_HUMAN",183,"P19105","ML12A_HUMAN","Myosin regulatory light chain 12A",null,"MYL12A"]
["23.4043","23.1914","23.4922","23.2891",{"$nulls":3},"2-oxoglutarate metabolic process;4-hydroxyproline catabolic process;aspartate biosynthetic process;aspartate catabolic process;aspartate metabolic process;cellular amino acid biosynthetic process;fatty acid transport;gluconeogenesis;glutamate catabolic process to 2-oxoglutarate;glutamate catabolic process to aspartate;glutamate metabolic process;glyoxylate metabolic process;oxaloacetate metabolic process;response to ethanol","4-hydroxyglutamate transaminase activity;amino acid binding;enzyme binding;kynurenine-oxoglutarate transaminase activity;L-aspartate:2-oxoglutarate aminotransferase activity;L-phenylalanine:2-oxoglutarate aminotransferase activity;phospholipid binding;protein homodimerization activity;pyridoxal phosphate binding;RNA binding","cell surface;extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;myelin sheath;perikaryon;plasma membrane;protein complex","2-Oxocarboxylic acid metabolism;Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Fat digestion and absorption;Metabolic pathways;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Tyrosine metabolism",null,null,13,13,13,"33.3","33.3","33.3","47.517",0,"30.674",2461000000,48,"0.227145","0.796226","-0.0927601","-0.630642","sp|P00505|AATM_HUMAN","sp|P00505|AATM_HUMAN",471,"P00505","AATM_HUMAN","Aspartate aminotransferase, mitochondrial","AspAT","GOT2"]
["22.6613","22.6185","22.987","22.481",{"$nulls":3},"negative regulation of coagulation","calcium ion binding;calcium-dependent phospholipid binding",{"$nulls":4},10,10,10,"39.5","39.5","39.5","33.552",0,"114.5",1242200000,51,"0.126942","0.89639","-0.0940838","-0.370532","tr|Q6P452|Q6P452_HUMAN;sp|P09525|ANXA4_HUMAN","tr|Q6P452|Q6P452_HUMAN;sp|P09525|ANXA4_HUMAN",587,"Q6P452","Q6P452_HUMAN","Annexin {ECO:0000256|RuleBase:RU003540}"]
["20.9758","21.0075","21.1921","20.9799",{"$nulls":3},"regulation of translational initiation;translational initiation","cadherin binding;GTP binding;GTPase activity;RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;cytosol;plasma membrane","RNA transport",null,null,5,5,5,"12.1","12.1","12.1","49.222",0,"14.762",424690000,34,"0.326256","0.705816","-0.0943737","-0.879754","sp|P55010|IF5_HUMAN;tr|H0YK11|H0YK11_HUMAN;tr|H0YMJ8|H0YMJ8_HUMAN;tr|H0YM54|H0YM54_HUMAN;tr|H0YLZ1|H0YLZ1_HUMAN;tr|H0YN40|H0YN40_HUMAN;tr|H0YK29|H0YK29_HUMAN","sp|P55010|IF5_HUMAN",1201,"P55010","IF5_HUMAN","Eukaryotic translation initiation factor 5","IF-5","EIF5"]
["22.7504","21.9703","22.3803","22.5301",{"$nulls":3},"D-gluconate metabolic process;oxidation-reduction process;pentose biosynthetic process;pentose-phosphate shunt;pentose-phosphate shunt, oxidative branch","phosphogluconate dehydrogenase (decarboxylating) activity","cytosol;extracellular exosome;nucleus","Carbon metabolism;Glutathione metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,12,12,12,"31.7","31.7","31.7","53.139",0,"160.56",1476500000,67,"0.0790713","0.929467","-0.094821","-0.238735","sp|P52209|6PGD_HUMAN;tr|K7EMN2|K7EMN2_HUMAN;tr|K7EM49|K7EM49_HUMAN;tr|K7EPF6|K7EPF6_HUMAN;tr|K7ELN9|K7ELN9_HUMAN","sp|P52209|6PGD_HUMAN;tr|K7EMN2|K7EMN2_HUMAN;tr|K7EM49|K7EM49_HUMAN;tr|K7EPF6|K7EPF6_HUMAN",1151,"P52209","6PGD_HUMAN","6-phosphogluconate dehydrogenase, decarboxylating",null,"PGD"]
["18.1232","17.7393","17.8474","18.205",{"$nulls":3},"adiponectin-activated signaling pathway;cellular protein complex assembly;endothelial tube morphogenesis;liver regeneration;macroautophagy;negative regulation of blood vessel endothelial cell migration;negative regulation of cell proliferation;neutrophil degranulation;peptidyl-threonine phosphorylation;phosphatidylcholine biosynthetic process;positive regulation of activin receptor signaling pathway;positive regulation of pathway-restricted SMAD protein phosphorylation;protein folding;regulation of DNA binding;regulation of signal transduction by p53 class mediator;response to testosterone;signal transduction;Wnt signaling pathway","chromatin binding;identical protein binding;metal ion binding;protein domain specific binding;protein kinase regulator activity;protein serine/threonine kinase activity;receptor binding;ribonucleoprotein complex binding;transcription factor binding","chromatin;cilium;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nuclear matrix;nucleoplasm;nucleus;plasma membrane;protein kinase CK2 complex;secretory granule lumen","Adherens junction;Measles;Mitophagy - animal;NF-kappa B signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Ribosome biogenesis in eukaryotes;Wnt signaling pathway",null,null,2,2,2,"11.6","11.6","11.6","24.942","0.001076","2.4171",29462000,6,"0.123678","0.902088","-0.0948944","-0.361754","sp|P67870|CSK2B_HUMAN;tr|Q5SRQ3|Q5SRQ3_HUMAN;tr|Q5SRQ6|Q5SRQ6_HUMAN;tr|N0E472|N0E472_HUMAN;tr|A0A0G2JM12|A0A0G2JM12_HUMAN;tr|N0E644|N0E644_HUMAN;tr|A0A0G2JM58|A0A0G2JM58_HUMAN","sp|P67870|CSK2B_HUMAN;tr|Q5SRQ3|Q5SRQ3_HUMAN;tr|Q5SRQ6|Q5SRQ6_HUMAN;tr|N0E472|N0E472_HUMAN;tr|A0A0G2JM12|A0A0G2JM12_HUMAN;tr|N0E644|N0E644_HUMAN;tr|A0A0G2JM58|A0A0G2JM58_HUMAN",1353,"P67870","CSK2B_HUMAN","Casein kinase II subunit beta","K II beta","CSNK2B"]
["23.4039","22.9353","23.5523","22.977",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex;secretory granule lumen","Proteasome",null,null,5,5,5,32,32,32,"26.411",0,"36.271",1121100000,29,"0.0852256","0.925977","-0.0950136","-0.256089","sp|P28066|PSA5_HUMAN","sp|P28066|PSA5_HUMAN",832,"P28066","PSA5_HUMAN","Proteasome subunit alpha type-5",null,"PSMA5"]
["17.6387","17.7345","17.9324","17.6309",{"$nulls":3},"actin filament polymerization;cytoskeleton organization;lamellipodium assembly;oligodendrocyte development;positive regulation of myelination;protein complex assembly;regulation of cell shape","actin binding","cytoplasm;cytoskeleton;extracellular exosome;lamellipodium","Adherens junction;Choline metabolism in cancer;Fc gamma R-mediated phagocytosis",null,null,1,1,1,"2.4","2.4","2.4","55.292","0.0010877","2.5236",27795000,1,"0.215463","0.804612","-0.0950699","-0.60099","sp|Q9UPY6|WASF3_HUMAN","sp|Q9UPY6|WASF3_HUMAN",2929,"Q9UPY6","WASF3_HUMAN","Wiskott-Aldrich syndrome protein family member 3","ASP family protein member 3","WASF3"]
["21.2159","21.0917","21.5847","20.9143",{"$nulls":3},"cell cycle;cell division;cilium assembly;neuron projection development;regulation of L-glutamate transport;regulation of protein localization;smoothened signaling pathway;spermatogenesis","cadherin binding;enzyme regulator activity;GTP binding;identical protein binding;protein complex scaffold activity","actin cytoskeleton;axoneme;ciliary membrane;cleavage furrow;condensed chromosome kinetochore;cytoplasm;cytosol;exocyst;extracellular exosome;midbody;myelin sheath;non-motile cilium;nucleolus;nucleus;perinuclear region of cytoplasm;photoreceptor connecting cilium;septin complex;sperm annulus;spindle;synapse","Bacterial invasion of epithelial cells",null,null,8,8,8,"29.1","29.1","29.1","41.487",0,"72.245",526090000,41,"0.0940551","0.920826","-0.0957088","-0.280755","sp|Q15019|SEPT2_HUMAN;tr|B5MCX3|B5MCX3_HUMAN;tr|C9J938|C9J938_HUMAN;tr|C9JB25|C9JB25_HUMAN;tr|C9J2Q4|C9J2Q4_HUMAN;tr|C9IY94|C9IY94_HUMAN;tr|C9IZU3|C9IZU3_HUMAN;tr|H7C310|H7C310_HUMAN;tr|C9JQJ4|C9JQJ4_HUMAN;tr|A0A0K0K1E7|A0A0K0K1E7_HUMAN;tr|C9JFT1|C9JFT1_HUMAN;tr|F8WB65|F8WB65_HUMAN;tr|B5MD47|B5MD47_HUMAN;tr|C9JZI2|C9JZI2_HUMAN;tr|H7C2Y0|H7C2Y0_HUMAN;tr|C9JT15|C9JT15_HUMAN;tr|C9JSE7|C9JSE7_HUMAN","sp|Q15019|SEPT2_HUMAN;tr|B5MCX3|B5MCX3_HUMAN;tr|C9J938|C9J938_HUMAN;tr|C9JB25|C9JB25_HUMAN;tr|C9J2Q4|C9J2Q4_HUMAN;tr|C9IY94|C9IY94_HUMAN;tr|C9IZU3|C9IZU3_HUMAN;tr|H7C310|H7C310_HUMAN",1662,"Q15019","SEPT2_HUMAN","Septin-2",null,"SEPT2"]
["16.8807","16.6906","17.4645","16.2993",{"$nulls":3},"positive regulation of basement membrane assembly involved in embryonic body morphogenesis;regulation of epithelial to mesenchymal transition;regulation of gastrulation;regulation of microtubule cytoskeleton organization",null,"basal cortex",{"$nulls":3},4,4,4,4,4,4,"151.16",0,"22.752",104380000,8,"0.0528379","0.947888","-0.0962667","-0.163077","sp|Q86UU1|PHLB1_HUMAN;tr|A0A087WZL0|A0A087WZL0_HUMAN","sp|Q86UU1|PHLB1_HUMAN;tr|A0A087WZL0|A0A087WZL0_HUMAN",1982,"Q86UU1","PHLB1_HUMAN","Pleckstrin homology-like domain family B member 1",null,"PHLDB1"]
["19.3036","18.9607","18.855","19.6035",{"$nulls":3},"autophagosome assembly;cellular defense response;cilium assembly;craniofacial suture morphogenesis;GTP metabolic process;negative regulation of transcription factor import into nucleus;protein transport","GTP binding;GTPase activity","autophagosome;cell junction;centrosome;cytoplasm;cytosol;endosome membrane;extracellular exosome;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane",{"$nulls":3},3,3,3,"17.7","17.7","17.7","26.659",0,"7.1774",83453000,6,"0.0780354","0.930427","-0.0970774","-0.2358","sp|Q9ULC3|RAB23_HUMAN","sp|Q9ULC3|RAB23_HUMAN",2888,"Q9ULC3","RAB23_HUMAN","Ras-related protein Rab-23",null,"RAB23"]
["23.3441","23.1035","23.512","23.1321",{"$nulls":3},"angiotensin maturation;COPII vesicle coating;epithelial tube branching involved in lung morphogenesis;ER to Golgi vesicle-mediated transport;negative regulation of neuron projection development;negative regulation of plasminogen activation;negative regulation of protein binding;neutrophil degranulation;positive regulation of neural precursor cell proliferation;positive regulation of neuron apoptotic process;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of neuron death","carboxypeptidase activity;cysteine-type endopeptidase activity;cysteine-type peptidase activity","cell cortex region;cell surface;COPII-coated ER to Golgi transport vesicle;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;Golgi membrane;growth cone;intracellular membrane-bounded organelle;lysosome;plasma membrane;specific granule lumen","Apoptosis;Lysosome",null,null,5,5,5,"19.5","19.5","19.5","33.868",0,"49.73",979490000,13,"0.151996","0.876046","-0.0982656","-0.437112","sp|Q9UBR2|CATZ_HUMAN","sp|Q9UBR2|CATZ_HUMAN",2809,"Q9UBR2","CATZ_HUMAN","Cathepsin Z",null,"CTSZ"]
["21.9563","22.0309","21.5111","22.6731",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;membrane","Ribosome",null,null,4,4,4,"32.5","32.5","32.5","18.565",0,"11.46",303590000,21,"0.0549114","0.946398","-0.0984888","-0.169166","sp|P46778|RL21_HUMAN;tr|G3V1B3|G3V1B3_HUMAN;tr|M0R181|M0R181_HUMAN","sp|P46778|RL21_HUMAN;tr|G3V1B3|G3V1B3_HUMAN;tr|M0R181|M0R181_HUMAN",1033,"P46778","RL21_HUMAN","60S ribosomal protein L21",null,"RPL21"]
["20.9089","21.0557","21.3903","20.7724",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;cellular response to glucagon stimulus;intracellular signal transduction;negative regulation of cAMP-dependent protein kinase activity;renal water homeostasis","cAMP binding;cAMP-dependent protein kinase inhibitor activity;cAMP-dependent protein kinase regulator activity;protein domain specific binding;protein kinase A catalytic subunit binding;ubiquitin protein ligase binding","cAMP-dependent protein kinase complex;centrosome;ciliary base;cytoplasm;cytosol;extracellular exosome;focal adhesion;membrane;nucleotide-activated protein kinase complex;plasma membrane;plasma membrane raft;protein complex","Insulin signaling pathway",null,null,6,6,6,21,21,21,"45.518",0,"29.514",429220000,29,"0.10537","0.912946","-0.0990744","-0.311994","sp|P13861|KAP2_HUMAN;tr|H7C330|H7C330_HUMAN;tr|C9J830|C9J830_HUMAN;tr|H7C1L0|H7C1L0_HUMAN","sp|P13861|KAP2_HUMAN",665,"P13861","KAP2_HUMAN","cAMP-dependent protein kinase type II-alpha regulatory subunit",null,"PRKAR2A"]
["18.6694","18.4479","18.7889","18.5281",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion","Ribosome",null,null,2,2,2,"6.8","6.8","6.8","33.249",0,"6.6845",65428000,10,"0.208682","0.814924","-0.0998583","-0.583721","sp|Q9Y399|RT02_HUMAN;tr|Q5T8A0|Q5T8A0_HUMAN","sp|Q9Y399|RT02_HUMAN;tr|Q5T8A0|Q5T8A0_HUMAN",2977,"Q9Y399","RT02_HUMAN","28S ribosomal protein S2, mitochondrial","2mt;RP-S2","MRPS2"]
["16.6317","16.4497","17.048","16.2331",{"$nulls":3},"sensory perception of pain","neurotransmitter binding","mitochondrial inner membrane;mitochondrion;synaptic membrane",{"$nulls":3},1,1,1,"4.9","4.9","4.9","33.31","0.0047442","1.9871",14178000,6,"0.079238","0.929825","-0.0998735","-0.239206","sp|Q9BPW8|NIPS1_HUMAN","sp|Q9BPW8|NIPS1_HUMAN",2406,"Q9BPW8","NIPS1_HUMAN","Protein NipSnap homolog 1","ipSnap1","NIPSNAP1"]
["23.5861","23.1452","23.7634","23.1727",{"$nulls":3},"activation of protein kinase B activity;adult locomotory behavior;autophagy;cellular response to glyoxal;cellular response to hydrogen peroxide;cellular response to oxidative stress;detoxification of copper ion;detoxification of mercury ion;DNA repair;dopamine uptake involved in synaptic transmission;enzyme active site formation via L-cysteine sulfinic acid;glucose homeostasis;glutathione deglycation;glycolate biosynthetic process;glyoxal metabolic process;guanine deglycation;guanine deglycation, glyoxal removal;guanine deglycation, methylglyoxal removal;hydrogen peroxide metabolic process;inflammatory response;insulin secretion;lactate biosynthetic process;membrane depolarization;membrane hyperpolarization;methylglyoxal metabolic process;mitochondrion organization;negative regulation of apoptotic process;negative regulation of cell death;negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;negative regulation of death-inducing signaling complex assembly;negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of gene expression;negative regulation of hydrogen peroxide-induced cell death;negative regulation of hydrogen peroxide-induced neuron death;negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway;negative regulation of neuron apoptotic process;negative regulation of neuron death;negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;negative regulation of oxidative stress-induced cell death;negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of protein acetylation;negative regulation of protein binding;negative regulation of protein export from nucleus;negative regulation of protein K48-linked deubiquitination;negative regulation of protein kinase activity;negative regulation of protein phosphorylation;negative regulation of protein sumoylation;negative regulation of protein ubiquitination;negative regulation of reactive oxygen species biosynthetic process;negative regulation of TRAIL-activated apoptotic signaling pathway;negative regulation of ubiquitin-protein transferase activity;negative regulation of ubiquitin-specific protease activity;peptidyl-arginine deglycation;peptidyl-cysteine deglycation;peptidyl-lysine deglycation;positive regulation of acute inflammatory response to antigenic stimulus;positive regulation of androgen receptor activity;positive regulation of autophagy of mitochondrion;positive regulation of DNA binding transcription factor activity;positive regulation of dopamine biosynthetic process;positive regulation of gene expression;positive regulation of interleukin-8 production;positive regulation of L-dopa biosynthetic process;positive regulation of L-dopa decarboxylase activity;positive regulation of mitochondrial electron transport, NADH to ubiquinone;positive regulation of NAD(P)H oxidase activity;positive regulation of oxidative phosphorylation uncoupler activity;positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein homodimerization activity;positive regulation of protein kinase B signaling;positive regulation of protein localization to nucleus;positive regulation of pyrroline-5-carboxylate reductase activity;positive regulation of reactive oxygen species biosynthetic process;positive regulation of superoxide dismutase activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription regulatory region DNA binding;positive regulation of tyrosine 3-monooxygenase activity;protein deglycation, glyoxal removal;protein deglycation, methylglyoxal removal;protein deglycosylation;protein stabilization;Ras protein signal transduction;regulation of androgen receptor signaling pathway;regulation of inflammatory response;regulation of mitochondrial membrane potential;regulation of neuron apoptotic process;regulation of supramolecular fiber organization;single fertilization","androgen receptor binding;cadherin binding;copper ion binding;cupric ion binding;cuprous ion binding;cytokine binding;enzyme binding;identical protein binding;kinase binding;L-dopa decarboxylase activator activity;mercury ion binding;mRNA binding;oxidoreductase activity, acting on peroxide as acceptor;peptidase activity;peroxiredoxin activity;protein deglycase activity;protein homodimerization activity;receptor binding;repressing transcription factor binding;scaffold protein binding;small protein activating enzyme binding;superoxide dismutase copper chaperone activity;transcription coactivator activity;transcription factor binding;tyrosine 3-monooxygenase activator activity;ubiquitin-like protein conjugating enzyme binding;ubiquitin-specific protease binding","axon;cell body;cell-cell adherens junction;chromatin;cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;membrane raft;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;nucleus;perinuclear region of cytoplasm;plasma membrane;PML body;presynapse","Parkinson disease",null,null,8,8,8,"52.4","52.4","52.4","19.891",0,"31.845",1418300000,54,"0.0929935","0.919981","-0.102396","-0.277803","sp|Q99497|PARK7_HUMAN;tr|K7ELW0|K7ELW0_HUMAN;tr|K7EN27|K7EN27_HUMAN","sp|Q99497|PARK7_HUMAN;tr|K7ELW0|K7ELW0_HUMAN;tr|K7EN27|K7EN27_HUMAN",2376,"Q99497","PARK7_HUMAN","Protein/nucleic acid deglycase DJ-1 {ECO:0000305|PubMed:25416785, ECO:0000305|PubMed:28596309}",null,"PARK7"]
["16.9916","16.761","16.7252","17.2322",{"$nulls":3},"histone H3-K9 demethylation;regulation of transcription, DNA-templated;response to cisplatin;transcription, DNA-templated","antioxidant activity;chromatin DNA binding;dioxygenase activity;histone demethylase activity;histone demethylase activity (H3-K9 specific);metal ion binding;transcription regulatory region sequence-specific DNA binding","chromatin;nucleoplasm;nucleus","Thermogenesis",null,null,7,7,7,"7.5","7.5","7.5","191.58",0,"35.151",96011000,22,"0.125911","0.89888","-0.102417","-0.367763","sp|Q7LBC6|KDM3B_HUMAN;tr|H0Y9V5|H0Y9V5_HUMAN","sp|Q7LBC6|KDM3B_HUMAN",1939,"Q7LBC6","KDM3B_HUMAN","Lysine-specific demethylase 3B",null,"KDM3B"]
["17.2257","16.8501","17.5577","16.7239",{"$nulls":3},"protein folding in endoplasmic reticulum",null,"ER membrane protein complex;integral component of membrane",{"$nulls":3},4,4,4,"5.9","5.9","5.9","111.76",0,"9.4124",72206000,8,"0.0742251","0.931779","-0.10287","-0.22497","sp|Q8N766|EMC1_HUMAN","sp|Q8N766|EMC1_HUMAN",2063,"Q8N766","EMC1_HUMAN","ER membrane protein complex subunit 1",null,"EMC1"]
["16.5752","16.8526","16.4759","17.1592",{"$nulls":3},"cellular protein metabolic process;G-protein coupled receptor signaling pathway;platelet degranulation;post-translational protein modification","DNA binding;heparin binding;identical protein binding;serine-type endopeptidase inhibitor activity;transition metal ion binding","endoplasmic reticulum lumen;extracellular exosome;integral component of membrane;membrane;nucleus;plasma membrane;platelet alpha granule membrane",{"$nulls":3},2,2,2,"2.9","2.9","2.9","86.955","0.0053782","1.9092",32511000,3,"0.0941916","0.920799","-0.103654","-0.281134","sp|Q06481|APLP2_HUMAN","sp|Q06481|APLP2_HUMAN",1460,"Q06481","APLP2_HUMAN","Amyloid-like protein 2","PLP-2","APLP2"]
["18.2705","19.9248","19.2142","19.1886",{"$nulls":9},5,5,5,"13.7","13.7","13.7","60.457",0,"21.172",102160000,12,"0.0401572","0.956424","-0.103728","-0.125392","tr|A0A0C4DGZ9|A0A0C4DGZ9_HUMAN;sp|O14773|TPP1_HUMAN","tr|A0A0C4DGZ9|A0A0C4DGZ9_HUMAN;sp|O14773|TPP1_HUMAN",172,"A0A0C4DGZ9"]
["18.4306","18.4695","19.7423","17.3654",{"$nulls":4},"transcription coactivator activity","nucleus",{"$nulls":3},1,1,1,"26.2","26.2","26.2","7.3251",0,"3.9053",17376000,8,"0.0276165","0.96696","-0.10376","-0.0872951","tr|J3KRT0|J3KRT0_HUMAN;tr|J3KS23|J3KS23_HUMAN;sp|Q13951|PEBB_HUMAN","tr|J3KRT0|J3KRT0_HUMAN;tr|J3KS23|J3KS23_HUMAN;sp|Q13951|PEBB_HUMAN",1593,"J3KRT0","J3KRT0_HUMAN",null,null,"CBFB"]
["21.4315","21.3633","21.9452","21.0573",{"$nulls":4},"RNA binding",{"$nulls":4},4,4,4,"50.7","50.7","50.7","14.563",0,"24.853",237820000,19,"0.0771376","0.931689","-0.103865","-0.233253","sp|Q96CP2|FWCH2_HUMAN;tr|I3L1Y9|I3L1Y9_HUMAN;tr|I3L4I0|I3L4I0_HUMAN;tr|I3L0R3|I3L0R3_HUMAN;tr|I3L231|I3L231_HUMAN;sp|Q4VC44|FWCH1_HUMAN","sp|Q96CP2|FWCH2_HUMAN;tr|I3L1Y9|I3L1Y9_HUMAN;tr|I3L4I0|I3L4I0_HUMAN",2249,"Q96CP2","FWCH2_HUMAN","FLYWCH family member 2",null,"FLYWCH2"]
["23.6772","23.2984","23.7756","23.409",{"$nulls":3},"energy derivation by oxidation of organic compounds;epithelial cell differentiation;fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA dehydrogenase;IRE1-mediated unfolded protein response;negative regulation of fatty acid biosynthetic process;negative regulation of fatty acid oxidation;regulation of cholesterol metabolic process;response to cold;temperature homeostasis","acyl-CoA dehydrogenase activity;flavin adenine dinucleotide binding;long-chain-acyl-CoA dehydrogenase activity","cytosol;mitochondrial inner membrane;mitochondrial matrix;mitochondrial membrane;mitochondrial nucleoid;mitochondrion;nucleolus;nucleus","Fatty acid degradation;Fatty acid metabolism;Metabolic pathways",null,null,25,25,25,"47.8","47.8","47.8","70.389",0,"323.31",4092300000,132,"0.136583","0.892502","-0.104462","-0.396315","sp|P49748|ACADV_HUMAN;tr|K7EQP4|K7EQP4_HUMAN;tr|G3V1M7|G3V1M7_HUMAN;tr|J3KS89|J3KS89_HUMAN;tr|J3QKU9|J3QKU9_HUMAN;tr|K7EJW8|K7EJW8_HUMAN;tr|J3QRJ8|J3QRJ8_HUMAN;tr|J3KSR4|J3KSR4_HUMAN;tr|K7EMF8|K7EMF8_HUMAN","sp|P49748|ACADV_HUMAN",1089,"P49748","ACADV_HUMAN","Very long-chain specific acyl-CoA dehydrogenase, mitochondrial","LCAD","ACADVL"]
["18.0989","17.786","18.662","17.4327",{"$nulls":3},"cell proliferation;cellular response to rapamycin;mRNA stabilization;negative regulation of translation;positive regulation of macroautophagy;positive regulation of viral genome replication;response to amino acid starvation;TOR signaling;TORC1 signaling;translational initiation","cadherin binding;eukaryotic initiation factor 4E binding;mRNA 3'-UTR binding;mRNA 5'-UTR binding;RNA binding;RNA cap binding;translation activator activity;translation initiation factor binding","cytoplasm;cytoplasmic stress granule;membrane",{"$nulls":3},9,9,9,"13.6","13.6","13.6","123.51",0,"52.922",194820000,17,"0.0536288","0.947543","-0.1049","-0.165402","sp|Q6PKG0|LARP1_HUMAN;tr|A0A0B4J210|A0A0B4J210_HUMAN;tr|E5RH50|E5RH50_HUMAN;tr|H0YC33|H0YC33_HUMAN;tr|H0YBW1|H0YBW1_HUMAN;tr|H0YC73|H0YC73_HUMAN;sp|Q659C4|LAR1B_HUMAN","sp|Q6PKG0|LARP1_HUMAN;tr|A0A0B4J210|A0A0B4J210_HUMAN;tr|E5RH50|E5RH50_HUMAN",1897,"Q6PKG0","LARP1_HUMAN","La-related protein 1",null,"LARP1"]
["17.5279","17.8774","17.9989","17.6179",{"$nulls":9},1,1,1,"11.3","11.3","11.3","17.479",0,"5.3926",14835000,8,"0.141438","0.884215","-0.10578","-0.409219","tr|E9PKW9|E9PKW9_HUMAN;tr|E9PQW9|E9PQW9_HUMAN;tr|B7Z6U3|B7Z6U3_HUMAN;tr|E9PP23|E9PP23_HUMAN;tr|E9PHY0|E9PHY0_HUMAN;tr|E9PQY3|E9PQY3_HUMAN;sp|P11117|PPAL_HUMAN","tr|E9PKW9|E9PKW9_HUMAN;tr|E9PQW9|E9PQW9_HUMAN;tr|B7Z6U3|B7Z6U3_HUMAN;tr|E9PP23|E9PP23_HUMAN;tr|E9PHY0|E9PHY0_HUMAN;tr|E9PQY3|E9PQY3_HUMAN;sp|P11117|PPAL_HUMAN",616,"E9PKW9","E9PKW9_HUMAN",null,null,"ACP2"]
["16.22","16.1776","16.5893","16.0217",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion","Ribosome",null,null,1,1,1,"2.1","2.1","2.1","48.006","0.0044399","2.0436",23773000,1,"0.128602","0.898408","-0.106724","-0.374989","sp|P82675|RT05_HUMAN","sp|P82675|RT05_HUMAN",1381,"P82675","RT05_HUMAN","28S ribosomal protein S5, mitochondrial","5mt;RP-S5","MRPS5"]
["19.0453","18.8277","19.9319","18.1562",{"$nulls":3},"exocytosis;negative regulation of neuron apoptotic process;neurotransmitter secretion;neutrophil degranulation;regulated exocytosis;synaptic vesicle exocytosis","ATP-dependent protein binding","azurophil granule membrane;clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;extracellular exosome;lysosomal membrane;melanosome;membrane;mitochondrion;plasma membrane;specific granule membrane;synaptic vesicle;terminal bouton","Protein processing in endoplasmic reticulum",null,null,2,2,2,"24.2","24.2","24.2","22.149",0,"4.0638",43047000,8,"0.0384212","0.957627","-0.107491","-0.12017","sp|Q9H3Z4|DNJC5_HUMAN","sp|Q9H3Z4|DNJC5_HUMAN",2593,"Q9H3Z4","DNJC5_HUMAN","DnaJ homolog subfamily C member 5 {ECO:0000305}",null,"DNAJC5"]
["16.684","16.5333","16.5837","16.8488",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;mitotic cell cycle checkpoint;response to ionizing radiation;snRNA processing;snRNA transcription from RNA polymerase II promoter",null,"cytoplasm;integrator complex;nucleolus;nucleoplasm;nucleus;SOSS complex",{"$nulls":3},1,1,1,"2.7","2.7","2.7","118.07",0,"25.224",48921000,13,"0.256968","0.766976","-0.10763","-0.705913","sp|Q68E01|INT3_HUMAN","sp|Q68E01|INT3_HUMAN",1860,"Q68E01","INT3_HUMAN","Integrator complex subunit 3","nt3","INTS3"]
["17.1202","16.9136","17.0478","17.2018",{"$nulls":4},"deaminase activity",{"$nulls":4},1,1,1,"5.3","5.3","5.3","29.328","0.0011099","2.7227",18436000,1,"0.309482","0.716393","-0.107931","-0.837684","tr|F5GXW0|F5GXW0_HUMAN;sp|P00813|ADA_HUMAN","tr|F5GXW0|F5GXW0_HUMAN;sp|P00813|ADA_HUMAN",475,"F5GXW0","F5GXW0_HUMAN",null,null,"ADA"]
["22.3726","22.2218","22.5936","22.2174",{"$nulls":3},"barbed-end actin filament capping;protein complex assembly","actin filament binding;cadherin binding;protein complex binding;protein domain specific binding","centriole;cytoplasm;extracellular exosome;F-actin capping protein complex;Flemming body;melanosome;mitotic spindle;nucleolus;nucleoplasm;nucleus",{"$nulls":3},7,7,7,"27.9","27.9","27.9","38.498",0,"52.631",648380000,42,"0.189446","0.830342","-0.108311","-0.534468","sp|P40121|CAPG_HUMAN;tr|E7ENU9|E7ENU9_HUMAN;tr|H7C0X8|H7C0X8_HUMAN;tr|B8ZZL6|B8ZZL6_HUMAN","sp|P40121|CAPG_HUMAN;tr|E7ENU9|E7ENU9_HUMAN",967,"P40121","CAPG_HUMAN","Macrophage-capping protein",null,"CAPG"]
["22.2372","22.131","22.6197","21.9661",{"$nulls":3},"chemical synaptic transmission;innate immune response;negative regulation of ER-associated ubiquitin-dependent protein catabolic process;protein deubiquitination;regulation of chemotaxis;regulation of proteasomal protein catabolic process;ubiquitin-dependent protein catabolic process","cysteine-type endopeptidase activity;endopeptidase inhibitor activity;proteasome binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;tRNA guanylyltransferase activity","cell surface;cytoplasmic vesicle;cytosol;extracellular exosome;nucleus;plasma membrane;proteasome complex;synapse",{"$nulls":3},13,13,13,"36.4","36.4","36.4","56.068",0,"90.658",1283900000,57,"0.111445","0.904817","-0.108802","-0.328607","sp|P54578|UBP14_HUMAN;tr|A6NJA2|A6NJA2_HUMAN;tr|J3QQT6|J3QQT6_HUMAN;tr|J3KS55|J3KS55_HUMAN;tr|H0YA47|H0YA47_HUMAN","sp|P54578|UBP14_HUMAN;tr|A6NJA2|A6NJA2_HUMAN",1192,"P54578","UBP14_HUMAN","Ubiquitin carboxyl-terminal hydrolase 14",null,"USP14"]
["19.3582","18.951","20.067","18.4599",{"$nulls":3},"cristae formation",null,"MICOS complex;mitochondrial crista junction;mitochondrial inner membrane;mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,"35.6","35.6","35.6","13.087",0,"25.268",20219000,5,"0.0421232","0.954993","-0.108827","-0.131288","sp|Q5XKP0|MIC13_HUMAN;tr|K7EIR2|K7EIR2_HUMAN","sp|Q5XKP0|MIC13_HUMAN;tr|K7EIR2|K7EIR2_HUMAN",1852,"Q5XKP0","MIC13_HUMAN","MICOS complex subunit MIC13 {ECO:0000305}",null,"MIC13"]
["18.8862","19.2412","19.3306","19.0196",{"$nulls":3},"cell differentiation;multicellular organism development;production of siRNA involved in RNA interference;spermatogenesis","DNA binding;metal ion binding;protein transporter activity;RNA binding;sequence-specific DNA binding","cytosol;Golgi apparatus;nucleus;perinuclear region of cytoplasm",{"$nulls":3},3,3,3,"19.3","19.3","19.3","33.112",0,"18.984",91879000,15,"0.165342","0.85791","-0.111402","-0.472066","sp|Q99598|TSNAX_HUMAN;tr|C4P0D6|C4P0D6_HUMAN;tr|C4P0D8|C4P0D8_HUMAN;tr|C4P0D4|C4P0D4_HUMAN;tr|Q5VVQ1|Q5VVQ1_HUMAN","sp|Q99598|TSNAX_HUMAN;tr|C4P0D6|C4P0D6_HUMAN;tr|C4P0D8|C4P0D8_HUMAN",2386,"Q99598","TSNAX_HUMAN","Translin-associated protein X",null,"TSNAX"]
["17.7452","17.6784","18.0461","17.6004",{"$nulls":3},"muscle contraction;muscle filament sliding;skeletal muscle tissue development","calcium ion binding;motor activity;structural constituent of muscle","cytosol;extracellular exosome;muscle myosin complex;myosin complex;unconventional myosin complex","Oxytocin signaling pathway;Tight junction;Vascular smooth muscle contraction",null,null,3,2,2,"17.8","11.5","11.5","22.764","0.0047538","2.0007",31025000,1,"0.173908","0.848557","-0.111404","-0.49434","sp|P14649|MYL6B_HUMAN;tr|F8W1I5|F8W1I5_HUMAN","sp|P14649|MYL6B_HUMAN;tr|F8W1I5|F8W1I5_HUMAN",673,"P14649","MYL6B_HUMAN","Myosin light chain 6B",null,"MYL6B"]
["21.3647","21.1055","21.1831","21.5104",{"$nulls":3},"hippo signaling","metal ion binding","cytosol;extracellular exosome;nucleolus;nucleus","Hippo signaling pathway;Hippo signaling pathway - multiple species",null,null,2,2,2,"10.6","10.6","10.6","25.079",0,"34.131",339540000,17,"0.189576","0.830266","-0.111638","-0.534802","sp|Q9H8S9|MOB1A_HUMAN;sp|Q7L9L4|MOB1B_HUMAN;tr|D6RCK3|D6RCK3_HUMAN","sp|Q9H8S9|MOB1A_HUMAN;sp|Q7L9L4|MOB1B_HUMAN;tr|D6RCK3|D6RCK3_HUMAN",1938,"Q9H8S9","MOB1A_HUMAN","MOB kinase activator 1A",null,"MOB1A"]
["19.6661","20.0036","20.1833","19.7113",{"$nulls":3},"5-phosphoribose 1-diphosphate biosynthetic process;glucose homeostasis;glycogen catabolic process;glycogen metabolic process;necroptotic process;neutrophil degranulation","AMP binding;ATP binding;bile acid binding;drug binding;glucose binding;glycogen phosphorylase activity;linear malto-oligosaccharide phosphorylase activity;protein homodimerization activity;purine nucleobase binding;pyridoxal phosphate binding;SHG alpha-glucan phosphorylase activity;vitamin binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;secretory granule lumen","Glucagon signaling pathway;Insulin resistance;Insulin signaling pathway;Metabolic pathways;Necroptosis;Starch and sucrose metabolism",null,null,10,10,8,"18.2","18.2","15.8","97.147",0,"87.831",595890000,58,"0.133294","0.896281","-0.112429","-0.387544","sp|P06737|PYGL_HUMAN;tr|E9PK47|E9PK47_HUMAN","sp|P06737|PYGL_HUMAN;tr|E9PK47|E9PK47_HUMAN",533,"P06737","PYGL_HUMAN","Glycogen phosphorylase, liver form",null,"PYGL"]
["23.5924","23.6","23.9209","23.4968",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;proteolysis;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to oxidative stress;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","peptidase activity;threonine-type endopeptidase activity","centrosome;cytosol;extracellular exosome;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex","Proteasome",null,null,11,11,11,"45.2","45.2","45.2","28.48",0,"99.117",1868500000,56,"0.188122","0.831996","-0.112627","-0.531062","sp|P28074|PSB5_HUMAN;tr|H0YJM8|H0YJM8_HUMAN","sp|P28074|PSB5_HUMAN",835,"P28074","PSB5_HUMAN","Proteasome subunit beta type-5",null,"PSMB5"]
["21.171","20.9399","21.5856","20.7515",{"$nulls":3},"DNA replication;tRNA metabolic process","aminoacyl-tRNA editing activity;DNA binding;D-tyrosyl-tRNA(Tyr) deacylase activity;metal ion binding;tRNA binding","cytoplasm;cytosol;nucleolus",{"$nulls":3},2,2,2,"14.8","14.8","14.8","23.423",0,"46.355",180540000,10,"0.0871111","0.925061","-0.11312","-0.261379","sp|Q8TEA8|DTD1_HUMAN","sp|Q8TEA8|DTD1_HUMAN",2125,"Q8TEA8","DTD1_HUMAN","D-aminoacyl-tRNA deacylase 1 {ECO:0000250|UniProtKB:Q8IIS0}","TD","DTD1"]
["21.4884","21.4478","21.9215","21.2424",{"$nulls":3},"muscle contraction","actin binding;calmodulin binding;myosin binding","actin cytoskeleton;intracellular membrane-bounded organelle;plasma membrane",{"$nulls":3},14,14,14,"32.5","32.5","32.5","64.168",0,"103.25",1075400000,64,"0.113734","0.903948","-0.113894","-0.33484","tr|E7EX44|E7EX44_HUMAN;tr|E9PGZ1|E9PGZ1_HUMAN;sp|Q05682|CALD1_HUMAN;tr|C9J813|C9J813_HUMAN;tr|C9JEK3|C9JEK3_HUMAN","tr|E7EX44|E7EX44_HUMAN;tr|E9PGZ1|E9PGZ1_HUMAN;sp|Q05682|CALD1_HUMAN;tr|C9J813|C9J813_HUMAN",3087,"E7EX44","E7EX44_HUMAN",null,null,"CALD1"]
["17.7804","18.7126","19.4145","17.3067",{"$nulls":3},"autophagy;cell death;cellular response to unfolded protein;defense response to Gram-negative bacterium;G2/M transition of mitotic cell cycle;Golgi organization;Golgi ribbon formation;Golgi to plasma membrane protein transport;innate immune response;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of receptor recycling;parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization;positive regulation of autophagy;positive regulation of xenophagy;protein targeting to Golgi;regulation of I-kappaB kinase/NF-kappaB signaling;signal transduction","identical protein binding;K63-linked polyubiquitin modification-dependent protein binding;metal ion binding;polyubiquitin modification-dependent protein binding;protein binding, bridging;protein C-terminus binding;Rab GTPase binding","autophagosome;cytoplasm;cytoplasmic vesicle;cytosol;Golgi apparatus;Golgi membrane;nucleoplasm;nucleus;perinuclear region of cytoplasm;recycling endosome membrane;trans-Golgi network","Mitophagy - animal",null,null,5,5,5,"11.1","11.1","11.1","65.92",0,"46.336",136450000,15,"0.0314431","0.964135","-0.114097","-0.0990128","sp|Q96CV9|OPTN_HUMAN;tr|A0A087X2G2|A0A087X2G2_HUMAN;tr|X6RKL2|X6RKL2_HUMAN;tr|A0A087WY28|A0A087WY28_HUMAN;tr|H7C1H4|H7C1H4_HUMAN","sp|Q96CV9|OPTN_HUMAN",2252,"Q96CV9","OPTN_HUMAN","Optineurin",null,"OPTN"]
["20.1313","18.9135","19.8604","19.4131",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial ribosome;mitochondrial small ribosomal subunit","Ribosome",null,null,3,3,3,"28.9","28.9","28.9","15.139",0,"8.1523",57734000,12,"0.0573547","0.945108","-0.114371","-0.176314","sp|O60783|RT14_HUMAN","sp|O60783|RT14_HUMAN",305,"O60783","RT14_HUMAN","28S ribosomal protein S14, mitochondrial","14mt;RP-S14","MRPS14"]
["20.6032","20.388","21.0765","20.1441",{"$nulls":3},"carnitine biosynthetic process;cellular aldehyde metabolic process;hormone metabolic process;neurotransmitter biosynthetic process;oxidation-reduction process","1-pyrroline dehydrogenase activity;3-chloroallyl aldehyde dehydrogenase activity;4-trimethylammoniobutyraldehyde dehydrogenase activity;aldehyde dehydrogenase (NAD) activity;aminobutyraldehyde dehydrogenase activity","cytoplasm;cytosol;extracellular exosome","Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Fatty acid degradation;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Lysine degradation;Metabolic pathways;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,9,9,9,"19.4","19.4","19.4","53.801",0,"12.869",383540000,16,"0.0794262","0.929588","-0.114713","-0.239739","sp|P49189|AL9A1_HUMAN","sp|P49189|AL9A1_HUMAN",1067,"P49189","AL9A1_HUMAN","4-trimethylaminobutyraldehyde dehydrogenase","MABADH","ALDH9A1"]
["20.074","20.9663","20.2637","21.0079",{"$nulls":3},"protein homotetramerization;visual perception;xenobiotic catabolic process","mRNA 3'-UTR binding;NADPH binding;NADPH:quinone reductase activity;zinc ion binding","cytosol;extracellular exosome",{"$nulls":3},6,6,6,"30.7","30.7","30.7","35.206",0,"47.676",269890000,22,"0.0651815","0.93745","-0.11563","-0.199036","sp|Q08257|QOR_HUMAN;tr|A6NP24|A6NP24_HUMAN;tr|C9JH92|C9JH92_HUMAN","sp|Q08257|QOR_HUMAN;tr|A6NP24|A6NP24_HUMAN;tr|C9JH92|C9JH92_HUMAN",1471,"Q08257","QOR_HUMAN","Quinone oxidoreductase",null,"CRYZ"]
["24.7537","24.5835","25.0044","24.5665",{"$nulls":3},"actin crosslink formation;actin cytoskeleton reorganization;adenylate cyclase-inhibiting dopamine receptor signaling pathway;cell junction assembly;cerebral cortex development;cilium assembly;cytoplasmic sequestering of protein;establishment of protein localization;formation of radial glial scaffolds;mitotic spindle assembly;mRNA transcription from RNA polymerase II promoter;negative regulation of apoptotic process;negative regulation of DNA binding transcription factor activity;negative regulation of protein catabolic process;negative regulation of transcription from RNA polymerase I promoter;platelet activation;platelet aggregation;platelet degranulation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of integrin-mediated signaling pathway;positive regulation of neural precursor cell proliferation;positive regulation of neuron migration;positive regulation of potassium ion transmembrane transport;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of transcription factor import into nucleus;protein localization to cell surface;protein localization to plasma membrane;protein stabilization;receptor clustering;regulation of cell migration;regulation of membrane repolarization during atrial cardiac muscle cell action potential;regulation of membrane repolarization during cardiac muscle cell action potential;semaphorin-plexin signaling pathway;wound healing, spreading of cells","actin filament binding;cadherin binding;Fc-gamma receptor I complex binding;G-protein coupled receptor binding;GTPase binding;ion channel binding;kinase binding;mu-type opioid receptor binding;potassium channel regulator activity;protein homodimerization activity;Rac GTPase binding;Ral GTPase binding;Rho GTPase binding;RNA binding;signal transducer activity;SMAD binding;small GTPase binding;transcription factor binding","actin cytoskeleton;actin filament;apical dendrite;cell-cell junction;cortical cytoskeleton;cytoplasm;cytosol;dendritic shaft;extracellular exosome;extracellular matrix;extracellular region;focal adhesion;membrane;Myb complex;neuronal cell body;nucleolus;nucleus;perinuclear region of cytoplasm;plasma membrane;Z disc","Focal adhesion;MAPK signaling pathway;Proteoglycans in cancer;Salmonella infection",null,null,107,107,96,"56.5","56.5","53.3","280.74",0,"323.31",44528000000,842,"0.175","0.846538","-0.116811","-0.497172","sp|P21333|FLNA_HUMAN;tr|Q5HY54|Q5HY54_HUMAN;tr|Q60FE5|Q60FE5_HUMAN;tr|A0A087WWY3|A0A087WWY3_HUMAN;tr|F8WE98|F8WE98_HUMAN;tr|H0Y5C6|H0Y5C6_HUMAN;tr|H0Y5F3|H0Y5F3_HUMAN;tr|H7C2E7|H7C2E7_HUMAN","sp|P21333|FLNA_HUMAN;tr|Q5HY54|Q5HY54_HUMAN;tr|Q60FE5|Q60FE5_HUMAN;tr|A0A087WWY3|A0A087WWY3_HUMAN",754,"P21333","FLNA_HUMAN","Filamin-A","LN-A","FLNA"]
["20.1837","20.2305","20.2553","20.3927",{"$nulls":3},"inositol biosynthetic process;inositol phosphate dephosphorylation;phosphatidylinositol phosphorylation","inositol monophosphate 1-phosphatase activity;inositol monophosphate 3-phosphatase activity;inositol monophosphate 4-phosphatase activity;metal ion binding",{"$nulls":4},3,3,3,25,25,25,"19.925",0,"5.3103",161790000,10,"0.60499","0.431244","-0.116908","-1.61182","tr|E5RIP7|E5RIP7_HUMAN;tr|H0YBL1|H0YBL1_HUMAN;sp|P29218|IMPA1_HUMAN;tr|E5RG13|E5RG13_HUMAN;tr|E5RG94|E5RG94_HUMAN;tr|E5RHE9|E5RHE9_HUMAN;tr|E5RI82|E5RI82_HUMAN;tr|E5RGY4|E5RGY4_HUMAN","tr|E5RIP7|E5RIP7_HUMAN;tr|H0YBL1|H0YBL1_HUMAN;sp|P29218|IMPA1_HUMAN;tr|E5RG13|E5RG13_HUMAN",844,"E5RIP7","E5RIP7_HUMAN","Inositol-1-monophosphatase {ECO:0000256|RuleBase:RU364068}",null,"IMPA1"]
["24.1032","24.5232","24.4305","24.431",{"$nulls":3},"cell redox homeostasis;cellular response to oxidative stress;hydrogen peroxide catabolic process;negative regulation of apoptotic process;regulation of apoptotic process;removal of superoxide radicals;response to oxidative stress","antioxidant activity;thioredoxin peroxidase activity","cytoplasm;cytosol;extracellular exosome",{"$nulls":3},11,10,10,"57.6",52,52,"21.892",0,"135.98",2514300000,43,"0.199174","0.821563","-0.1175","-0.559428","sp|P32119|PRDX2_HUMAN;tr|A6NIW5|A6NIW5_HUMAN","sp|P32119|PRDX2_HUMAN",901,"P32119","PRDX2_HUMAN","Peroxiredoxin-2",null,"PRDX2"]
["19.7991","20.5573","20.37","20.2221",{"$nulls":9},1,1,1,"0.7","0.7","0.7","174.02","0.0047684","2.0187",1527000000,9,"0.102859","0.914541","-0.117844","-0.305096","tr|H7C5W6|H7C5W6_HUMAN;sp|Q86XA9|HTR5A_HUMAN;tr|F5H619|F5H619_HUMAN","tr|H7C5W6|H7C5W6_HUMAN;sp|Q86XA9|HTR5A_HUMAN;tr|F5H619|F5H619_HUMAN",1996,"H7C5W6","H7C5W6_HUMAN",null,null,"HEATR5A"]
["14.3558",1,"14.5933",1,{"$nulls":3},"hippo signaling;Wnt signaling pathway","identical protein binding","apical plasma membrane;bicellular tight junction;cytosol;recycling endosome","Tight junction",null,null,1,1,1,"1.8","1.8","1.8","85.763",0,"5.4184",9177800,3,"0.00384423","0.991592","-0.118755","-0.0124634","sp|Q9Y2J4|AMOL2_HUMAN","sp|Q9Y2J4|AMOL2_HUMAN",2951,"Q9Y2J4","AMOL2_HUMAN","Angiomotin-like protein 2",null,"AMOTL2"]
["16.2995","16.3446","16.7903","16.0924",{"$nulls":3},"actin modification;barbed-end actin filament capping;cell cycle;cell division;positive regulation of substrate adhesion-dependent cell spreading","actin filament binding;GTP-Rho binding;myosin II binding;ubiquitin protein ligase binding","actin cytoskeleton;cytoplasm;focal adhesion;microtubule organizing center;midbody;nucleus",{"$nulls":3},3,3,3,"1.4","1.4","1.4","261.37",0,"15.71",97285000,10,"0.11602","0.903922","-0.119257","-0.341052","sp|Q9H2D6|TARA_HUMAN;tr|F6WYE2|F6WYE2_HUMAN;tr|F6TR96|F6TR96_HUMAN;tr|H0Y5J9|H0Y5J9_HUMAN","sp|Q9H2D6|TARA_HUMAN;tr|F6WYE2|F6WYE2_HUMAN;tr|F6TR96|F6TR96_HUMAN;tr|H0Y5J9|H0Y5J9_HUMAN",2576,"Q9H2D6","TARA_HUMAN","TRIO and F-actin-binding protein",null,"TRIOBP"]
["21.4428","21.2922","22.0696","20.9049",{"$nulls":5},"cytosol;endoplasmic reticulum",{"$nulls":3},15,15,15,"35.8","35.8","35.8","72.798",0,"108.37",882320000,92,"0.0668974","0.935512","-0.11978","-0.203982","tr|E9PCH5|E9PCH5_HUMAN;tr|B7Z574|B7Z574_HUMAN;sp|P20810|ICAL_HUMAN;tr|A0A0C4DGB5|A0A0C4DGB5_HUMAN;tr|H0Y7F0|H0Y7F0_HUMAN;tr|E9PDE4|E9PDE4_HUMAN;tr|E7ES10|E7ES10_HUMAN;tr|E7EVY3|E7EVY3_HUMAN;tr|E7EQ12|E7EQ12_HUMAN;tr|H0Y9H6|H0Y9H6_HUMAN;tr|E7EQA0|E7EQA0_HUMAN;tr|A0A0A0MR45|A0A0A0MR45_HUMAN;tr|H0YD33|H0YD33_HUMAN;tr|A0A0C4DGD1|A0A0C4DGD1_HUMAN;tr|F8W7E0|F8W7E0_HUMAN;tr|D6RAA8|D6RAA8_HUMAN;tr|D6RC54|D6RC54_HUMAN;tr|E7EQK6|E7EQK6_HUMAN;tr|H0Y944|H0Y944_HUMAN;tr|H0YA91|H0YA91_HUMAN;tr|E9PSG1|E9PSG1_HUMAN","tr|E9PCH5|E9PCH5_HUMAN;tr|B7Z574|B7Z574_HUMAN;sp|P20810|ICAL_HUMAN;tr|A0A0C4DGB5|A0A0C4DGB5_HUMAN;tr|H0Y7F0|H0Y7F0_HUMAN;tr|E9PDE4|E9PDE4_HUMAN;tr|E7ES10|E7ES10_HUMAN;tr|E7EVY3|E7EVY3_HUMAN;tr|E7EQ12|E7EQ12_HUMAN;tr|H0Y9H6|H0Y9H6_HUMAN;tr|E7EQA0|E7EQA0_HUMAN;tr|A0A0A0MR45|A0A0A0MR45_HUMAN;tr|H0YD33|H0YD33_HUMAN",747,"E9PCH5","E9PCH5_HUMAN",null,null,"CAST"]
["16.6108","16.5517","16.9621","16.4405",{"$nulls":3},"carbohydrate metabolic process;keratan sulfate biosynthetic process;O-glycan processing","beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;galactosyltransferase activity;metal ion binding","extracellular exosome;Golgi cisterna membrane;Golgi membrane;integral component of membrane","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,1,1,1,"4.4","4.4","4.4","45.118","0.0011261","2.804",11643000,2,"0.159753","0.866329","-0.120051","-0.457466","sp|O43286|B4GT5_HUMAN","sp|O43286|B4GT5_HUMAN",238,"O43286","B4GT5_HUMAN","Beta-1,4-galactosyltransferase 5","4Gal-T5;eta-1,4-GalTase 5;eta4Gal-T5","B4GALT5"]
["22.8489","22.4142","22.9888","22.5155",{"$nulls":3},"cardiolipin acyl-chain remodeling;fatty acid beta-oxidation","3-hydroxyacyl-CoA dehydrogenase activity;acetyl-CoA C-acyltransferase activity;enoyl-CoA hydratase activity;long-chain-3-hydroxyacyl-CoA dehydrogenase activity;RNA binding","endoplasmic reticulum;extracellular exosome;mitochondrial envelope;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrial outer membrane;mitochondrion","Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,15,15,15,"39.2","39.2","39.2","51.294",0,"59.442",1681700000,71,"0.128713","0.898402","-0.120592","-0.375286","sp|P55084|ECHB_HUMAN;tr|B5MD38|B5MD38_HUMAN;tr|F5GZQ3|F5GZQ3_HUMAN;tr|C9JEY0|C9JEY0_HUMAN;tr|C9JE81|C9JE81_HUMAN;tr|C9K0M0|C9K0M0_HUMAN","sp|P55084|ECHB_HUMAN;tr|B5MD38|B5MD38_HUMAN;tr|F5GZQ3|F5GZQ3_HUMAN",1206,"P55084","ECHB_HUMAN","Trifunctional enzyme subunit beta, mitochondrial",null,"HADHB"]
["21.5952","21.6679","22.2079","21.2972",{"$nulls":3},"ATP metabolic process;nucleobase-containing small molecule interconversion;nucleoside diphosphate phosphorylation;nucleoside triphosphate biosynthetic process","adenylate kinase activity;ATP binding;nucleoside diphosphate kinase activity","cytosol;extracellular exosome","Metabolic pathways;Purine metabolism;Thiamine metabolism",null,null,5,5,5,"29.4","29.4","29.4","21.635",0,"67.795",355990000,26,"0.0883623","0.924042","-0.120996","-0.264882","sp|P00568|KAD1_HUMAN;tr|Q5T9B7|Q5T9B7_HUMAN;tr|H0YID2|H0YID2_HUMAN;tr|H0Y4J6|H0Y4J6_HUMAN","sp|P00568|KAD1_HUMAN;tr|Q5T9B7|Q5T9B7_HUMAN;tr|H0YID2|H0YID2_HUMAN;tr|H0Y4J6|H0Y4J6_HUMAN",474,"P00568","KAD1_HUMAN","Adenylate kinase isoenzyme 1 {ECO:0000255|HAMAP-Rule:MF_03171}","K 1 {ECO:0000255|HAMAP-Rule:MF_03171}","AK1"]
["25.3992","25.4179","25.4191","25.6401",{"$nulls":3},"aerobic respiration;gluconeogenesis;internal protein amino acid acetylation;malate metabolic process;NADH metabolic process;oxaloacetate metabolic process;tricarboxylic acid cycle","L-malate dehydrogenase activity;malate dehydrogenase (NADP+) activity;protein self-association;RNA binding","extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;myelin sheath;nucleus","Carbon metabolism;Citrate cycle (TCA cycle);Cysteine and methionine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Pyruvate metabolism",null,null,16,16,16,"61.5","61.5","61.5","35.503",0,"89.704",7681000000,126,"0.409848","0.608","-0.121003","-1.09101","sp|P40926|MDHM_HUMAN;tr|G3XAL0|G3XAL0_HUMAN","sp|P40926|MDHM_HUMAN;tr|G3XAL0|G3XAL0_HUMAN",976,"P40926","MDHM_HUMAN","Malate dehydrogenase, mitochondrial",null,"MDH2"]
["22.1261","21.897","22.2763","21.9888",{"$nulls":3},"arginyl-tRNA aminoacylation;tRNA aminoacylation for protein translation","arginine binding;arginine-tRNA ligase activity;ATP binding;cadherin binding;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;extracellular exosome;membrane;mitochondrion;nucleoplasm;nucleus","Aminoacyl-tRNA biosynthesis",null,null,19,19,19,"35.3","35.3","35.3","75.378",0,"95.49",1617400000,78,"0.23806","0.787196","-0.121009","-0.658254","sp|P54136|SYRC_HUMAN;tr|E5RJM9|E5RJM9_HUMAN;tr|E5RH09|E5RH09_HUMAN","sp|P54136|SYRC_HUMAN",1189,"P54136","SYRC_HUMAN","Arginine--tRNA ligase, cytoplasmic",null,"RARS"]
["16.2043","16.2823","16.3184","16.4112",{"$nulls":3},"cytoskeleton organization;post-translational protein modification;protein ubiquitination",null,"Cul3-RING ubiquitin ligase complex;cytoplasm;cytoskeleton;cytosol",{"$nulls":3},1,1,1,"2.3","2.3","2.3","67.638",0,"17.401",26397000,7,"0.737458","0.344684","-0.121508","-2.00342","sp|Q9H2C0|GAN_HUMAN","sp|Q9H2C0|GAN_HUMAN",2575,"Q9H2C0","GAN_HUMAN","Gigaxonin",null,"GAN"]
["21.8294","21.7405","22.0989","21.7145",{"$nulls":3},"cellular response to hypoxia;cholesterol biosynthetic process;fatty acid beta-oxidation;negative regulation of mitochondrial membrane permeability involved in apoptotic process;negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway","acetyl-CoA C-acyltransferase activity;RNA binding","extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,9,9,9,"38.5","38.5","38.5","41.924",0,"156.87",557360000,40,"0.22183","0.801669","-0.121764","-0.617165","sp|P42765|THIM_HUMAN;tr|A0A0B4J2A4|A0A0B4J2A4_HUMAN;tr|K7EME0|K7EME0_HUMAN;tr|K7EJ68|K7EJ68_HUMAN;tr|K7ER88|K7ER88_HUMAN;tr|K7EJB1|K7EJB1_HUMAN","sp|P42765|THIM_HUMAN;tr|A0A0B4J2A4|A0A0B4J2A4_HUMAN;tr|K7EME0|K7EME0_HUMAN",998,"P42765","THIM_HUMAN","3-ketoacyl-CoA thiolase, mitochondrial",null,"ACAA2"]
["16.1865","15.6273","16.372","15.6868",{"$nulls":3},"cell cycle;chaperone mediated protein folding requiring cofactor;clathrin coat disassembly;clathrin-coated pit assembly;clathrin-dependent endocytosis;endoplasmic reticulum organization;establishment of protein localization to Golgi;Golgi organization;Golgi to lysosome transport;membrane organization;negative regulation of neuron projection development;protein localization to plasma membrane;receptor-mediated endocytosis;synaptic vesicle uncoating","ATP binding;chaperone binding;cyclin binding;protein serine/threonine kinase activity","cytosol;focal adhesion;Golgi apparatus;intracellular membrane-bounded organelle;membrane;perinuclear region of cytoplasm;synapse;vesicle",{"$nulls":3},4,4,4,"4.8","4.8","4.8","143.19",0,"24.892",55756000,6,"0.092707","0.919651","-0.122493","-0.277006","sp|O14976|GAK_HUMAN;tr|D6RAW3|D6RAW3_HUMAN;tr|A0A087X1U9|A0A087X1U9_HUMAN;tr|D6RF16|D6RF16_HUMAN;tr|D6RAQ7|D6RAQ7_HUMAN;tr|D6RE78|D6RE78_HUMAN;tr|H0Y8H5|H0Y8H5_HUMAN","sp|O14976|GAK_HUMAN;tr|D6RAW3|D6RAW3_HUMAN;tr|A0A087X1U9|A0A087X1U9_HUMAN",186,"O14976","GAK_HUMAN","Cyclin-G-associated kinase",null,"GAK"]
["16.9934","17.8367","18.5022","16.5739",{"$nulls":3},"ubiquitin-dependent protein catabolic process","ubiquitin-ubiquitin ligase activity","ubiquitin ligase complex",{"$nulls":3},1,1,1,"2.6","2.6","2.6","62.002",0,"17.072",52230000,9,"0.0373278","0.957869","-0.12299","-0.116872","tr|B7Z7P0|B7Z7P0_HUMAN;sp|Q14139|UBE4A_HUMAN","tr|B7Z7P0|B7Z7P0_HUMAN;sp|Q14139|UBE4A_HUMAN",1601,"B7Z7P0","B7Z7P0_HUMAN",null,null,"UBE4A"]
["19.8634","19.8985","20.4545","19.555",{"$nulls":3},"cellular response to testosterone stimulus;centrosome duplication;cortical actin cytoskeleton organization;cytokinesis;ephrin receptor signaling pathway;G-protein coupled receptor signaling pathway;I-kappaB kinase/NF-kappaB signaling;negative regulation of angiogenesis;negative regulation of bicellular tight junction assembly;negative regulation of myosin-light-chain-phosphatase activity;positive regulation of centrosome duplication;positive regulation of endothelial cell migration;positive regulation of gene expression;positive regulation of protein phosphorylation;protein localization to plasma membrane;protein phosphorylation;regulation of actin cytoskeleton organization;regulation of cell adhesion;regulation of cell motility;regulation of circadian rhythm;regulation of establishment of cell polarity;regulation of establishment of endothelial barrier;regulation of focal adhesion assembly;regulation of keratinocyte differentiation;regulation of stress fiber assembly;Rho protein signal transduction;rhythmic process;smooth muscle contraction;vascular endothelial growth factor receptor signaling pathway;viral RNA genome replication","ATP binding;metal ion binding;protein serine/threonine kinase activity;Rho GTPase binding;Rho-dependent protein serine/threonine kinase activity;RNA binding;structural molecule activity","centrosome;cytoplasmic ribonucleoprotein granule;cytosol;nucleus;plasma membrane","Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Focal adhesion;Human cytomegalovirus infection;Leukocyte transendothelial migration;Oxytocin signaling pathway;Pathogenic Escherichia coli infection;Pathways in cancer;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis;Sphingolipid signaling pathway;Tight junction;Vascular smooth muscle contraction;Wnt signaling pathway;Yersinia infection",null,null,15,15,14,"15.1","15.1","13.9","160.9",0,"201.51",835290000,74,"0.0920004","0.921151","-0.123794","-0.275038","sp|O75116|ROCK2_HUMAN;tr|E9PF63|E9PF63_HUMAN;tr|Q14DU5|Q14DU5_HUMAN;tr|D6REE7|D6REE7_HUMAN","sp|O75116|ROCK2_HUMAN;tr|E9PF63|E9PF63_HUMAN;tr|Q14DU5|Q14DU5_HUMAN",318,"O75116","ROCK2_HUMAN","Rho-associated protein kinase 2",null,"ROCK2"]
["19.8803","19.1842","19.9858","19.327",{"$nulls":3},"blood circulation;cellular response to heat;muscle contraction;myoblast fusion;plasma membrane repair;regulation of vascular endothelial growth factor receptor signaling pathway","phospholipid binding","caveola;cytoplasmic vesicle;cytoplasmic vesicle membrane;extracellular exosome;integral component of membrane;intracellular membrane-bounded organelle;nuclear envelope;nuclear membrane;plasma membrane",{"$nulls":3},17,17,17,"10.8","10.8","10.8","234.71",0,"47.594",1060100000,62,"0.086261","0.926039","-0.12411","-0.258995","sp|Q9NZM1|MYOF_HUMAN;tr|H0YD14|H0YD14_HUMAN","sp|Q9NZM1|MYOF_HUMAN;tr|H0YD14|H0YD14_HUMAN",2761,"Q9NZM1","MYOF_HUMAN","Myoferlin",null,"MYOF"]
["20.871","20.7864","21.1882","20.7177",{"$nulls":3},"cell division;establishment of spindle orientation;microtubule sliding;mitotic spindle organization;negative regulation of non-motile cilium assembly;neuron projection development","microtubule binding;RNA binding;structural molecule activity","axoneme;extracellular exosome;microtubule;microtubule associated complex;mitotic spindle;neuron projection;postsynaptic density",{"$nulls":3},16,16,16,"20.5","20.5","20.5",121,0,"129.12",1303200000,87,"0.183834","0.833381","-0.12429","-0.520015","sp|P27816|MAP4_HUMAN;tr|E7EVA0|E7EVA0_HUMAN;tr|H0Y2V1|H0Y2V1_HUMAN;tr|H7C4C5|H7C4C5_HUMAN;tr|B5MEG9|B5MEG9_HUMAN;tr|F8W9U4|F8W9U4_HUMAN;tr|H7C456|H7C456_HUMAN;tr|A0A0J9YVV8|A0A0J9YVV8_HUMAN;tr|A0A0J9YW37|A0A0J9YW37_HUMAN","sp|P27816|MAP4_HUMAN;tr|E7EVA0|E7EVA0_HUMAN",829,"P27816","MAP4_HUMAN","Microtubule-associated protein 4","AP-4","MAP4"]
["15.444","16.3842","15.7969","16.2814",{"$nulls":5},"nuclear speck",{"$nulls":3},2,2,2,"2.4","2.4","2.4","110.26",0,"5.2579",13753000,2,"0.0782543","0.93061","-0.125037","-0.23642","sp|Q8N3X1|FNBP4_HUMAN;tr|F5GXL1|F5GXL1_HUMAN","sp|Q8N3X1|FNBP4_HUMAN;tr|F5GXL1|F5GXL1_HUMAN",2048,"Q8N3X1","FNBP4_HUMAN","Formin-binding protein 4",null,"FNBP4"]
["15.527","15.4226","16.0541","15.1465",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;protein localization to pericentriolar material","DNA binding transcription factor activity;RNA binding;sequence-specific DNA binding","cis-Golgi network;endoplasmic reticulum-Golgi intermediate compartment;Golgi apparatus;Golgi membrane;Golgi stack;integral component of membrane;membrane",{"$nulls":3},8,8,8,4,4,4,"376.01",0,"13.449",114620000,14,"0.0918525","0.920968","-0.125446","-0.274627","sp|Q14789|GOGB1_HUMAN;tr|E7EU81|E7EU81_HUMAN;tr|H0Y867|H0Y867_HUMAN","sp|Q14789|GOGB1_HUMAN;tr|E7EU81|E7EU81_HUMAN",1645,"Q14789","GOGB1_HUMAN","Golgin subfamily B member 1",null,"GOLGB1"]
["21.781","21.3024","22.4191","20.9159",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;ciliary basal body-plasma membrane docking;ER to Golgi vesicle-mediated transport;G2/M transition of mitotic cell cycle;microtubule-based movement;positive regulation of ATP-dependent microtubule motor activity, plus-end-directed;regulation of G2/M transition of mitotic cell cycle;sister chromatid cohesion;transport along microtubule;viral process","dynein heavy chain binding;dynein light chain binding;microtubule motor activity","centrosome;cytoplasm;cytoplasmic dynein complex;cytosol;microtubule;vesicle","Phagosome;Salmonella infection;Vasopressin-regulated water reabsorption",null,null,9,9,4,"23.4","23.4",11,"71.456",0,"148.65",761500000,48,"0.0515996","0.948701","-0.125753","-0.159432","sp|Q13409|DC1I2_HUMAN;tr|E7ESD3|E7ESD3_HUMAN;tr|E7EMU4|E7EMU4_HUMAN;tr|E7ET01|E7ET01_HUMAN;tr|E7EUM4|E7EUM4_HUMAN;tr|E7ERR6|E7ERR6_HUMAN;tr|E7ERH4|E7ERH4_HUMAN;tr|E7EU01|E7EU01_HUMAN","sp|Q13409|DC1I2_HUMAN",1549,"Q13409","DC1I2_HUMAN","Cytoplasmic dynein 1 intermediate chain 2",null,"DYNC1I2"]
["23.5751","23.3433","23.9208","23.2491",{"$nulls":3},"chaperone-mediated protein complex assembly;protein import into mitochondrial outer membrane;response to unfolded protein","ATP binding","cytosol;extracellular exosome","Antigen processing and presentation;Tight junction",null,null,32,32,31,"51.7","51.7","49.8","94.33",0,"323.31",5781600000,207,"0.120822","0.902502","-0.125787","-0.354051","sp|P34932|HSP74_HUMAN;tr|A0A087WYC1|A0A087WYC1_HUMAN;tr|A0A087WTS8|A0A087WTS8_HUMAN","sp|P34932|HSP74_HUMAN;tr|A0A087WYC1|A0A087WYC1_HUMAN",918,"P34932","HSP74_HUMAN","Heat shock 70 kDa protein 4",null,"HSPA4"]
["16.8094","16.1516","16.8955","16.3222",{"$nulls":4},"identical protein binding","cell junction;extracellular exosome;synaptic vesicle;synaptic vesicle membrane",{"$nulls":3},1,1,1,14,14,14,"30.211","0.001078","2.426",17142000,5,"0.0988621","0.91625","-0.128296","-0.294075","sp|Q5T0D9|TPRGL_HUMAN","sp|Q5T0D9|TPRGL_HUMAN",1825,"Q5T0D9","TPRGL_HUMAN","Tumor protein p63-regulated gene 1-like protein",null,"TPRG1L"]
["21.7322","22.127","21.9223","22.1956",{"$nulls":9},1,1,1,11,11,11,"9.4195","0.0066379","1.8269",45838000,3,"0.19119","0.830014","-0.129384","-0.538952","tr|E7EST3|E7EST3_HUMAN;tr|E9PKV8|E9PKV8_HUMAN;sp|Q8N5M4|TTC9C_HUMAN","tr|E7EST3|E7EST3_HUMAN;tr|E9PKV8|E9PKV8_HUMAN;sp|Q8N5M4|TTC9C_HUMAN",2059,"E7EST3","E7EST3_HUMAN",null,null,"TTC9C"]
["16.6188","16.5793","17.4277","16.0295",{"$nulls":3},"endocytic recycling;protein transport","SNARE binding","EARP complex;extracellular exosome;membrane;recycling endosome",{"$nulls":3},4,4,4,"7.2","7.2","7.2","111.17",0,"6.7942",56022000,13,"0.0604059","0.944413","-0.129527","-0.185204","sp|Q96JG6|VPS50_HUMAN;tr|C9JA29|C9JA29_HUMAN;tr|H0Y7Q2|H0Y7Q2_HUMAN;tr|F8WDT1|F8WDT1_HUMAN;tr|F2Z3F0|F2Z3F0_HUMAN","sp|Q96JG6|VPS50_HUMAN;tr|C9JA29|C9JA29_HUMAN;tr|H0Y7Q2|H0Y7Q2_HUMAN",2305,"Q96JG6","VPS50_HUMAN","Syndetin {ECO:0000303|PubMed:25799061}",null,"VPS50"]
["21.5834","21.7118","22.242","21.3153",{"$nulls":4},"magnesium ion binding;NAD binding;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","mitochondrion",{"$nulls":3},6,6,6,"24.5","24.5","24.5","35.786",0,"24.597",565020000,29,"0.0938486","0.920678","-0.131057","-0.280181","tr|H0YL72|H0YL72_HUMAN;sp|P50213|IDH3A_HUMAN;tr|H0YLI6|H0YLI6_HUMAN;tr|H0YMU3|H0YMU3_HUMAN;tr|H0YKD0|H0YKD0_HUMAN;tr|H0YM64|H0YM64_HUMAN;tr|H0YNF5|H0YNF5_HUMAN","tr|H0YL72|H0YL72_HUMAN;sp|P50213|IDH3A_HUMAN;tr|H0YLI6|H0YLI6_HUMAN;tr|H0YMU3|H0YMU3_HUMAN;tr|H0YKD0|H0YKD0_HUMAN",1107,"H0YL72","H0YL72_HUMAN",null,null,"IDH3A"]
["17.0062","16.7698","17.1627","16.8759",{"$nulls":4},"oxidoreductase activity","mitochondrion",{"$nulls":3},2,2,2,"6.1","6.1","6.1","48.475","0.0010949","2.5698",28861000,9,"0.257196","0.767726","-0.131299","-0.706487","tr|C9JVN9|C9JVN9_HUMAN;sp|Q9H9P8|L2HDH_HUMAN;tr|G3V5S1|G3V5S1_HUMAN;tr|G3V272|G3V272_HUMAN","tr|C9JVN9|C9JVN9_HUMAN;sp|Q9H9P8|L2HDH_HUMAN;tr|G3V5S1|G3V5S1_HUMAN;tr|G3V272|G3V272_HUMAN",2625,"C9JVN9","C9JVN9_HUMAN",null,null,"L2HGDH"]
["18.4204","18.0193","19.4726","17.2298",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;aorta development;cellular response to carbon monoxide;cellular response to dopamine;cellular response to nitric oxide;cellular response to X-ray;coronary vasculature development;dynamin family protein polymerization involved in mitochondrial fission;endocytosis;G2/M transition of mitotic cell cycle;Golgi to plasma membrane transport;G-protein coupled receptor internalization;macropinocytosis;membrane fusion;membrane organization;mitochondrial fission;negative regulation of membrane tubulation;negative regulation of non-motile cilium assembly;negative regulation of transforming growth factor beta receptor signaling pathway;neuron projection morphogenesis;phagocytosis;positive regulation of apoptotic process;positive regulation of lamellipodium assembly;positive regulation of nitric oxide biosynthetic process;positive regulation of phagocytosis;positive regulation of sodium:potassium-exchanging ATPase activity;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of transcription, DNA-templated;receptor internalization;receptor-mediated endocytosis;regulation of axon extension;regulation of Golgi organization;regulation of nitric-oxide synthase activity;regulation of Rac protein signal transduction;regulation of transcription, DNA-templated;response to cocaine;response to light stimulus;signal transduction;spermatogenesis;synaptic vesicle transport;transferrin transport;ventricular septum development","D2 dopamine receptor binding;enzyme binding;GTP binding;GTPase activity;microtubule binding;nitric-oxide synthase binding;phosphatidylinositol 3-kinase regulatory subunit binding;protein complex binding;protein kinase binding;SH3 domain binding;WW domain binding","centrosome;clathrin-coated endocytic vesicle;clathrin-coated pit;cytosol;endocytic vesicle membrane;endosome;extracellular exosome;focal adhesion;Golgi apparatus;Golgi membrane;growth cone;lamellipodium;microtubule;midbody;mitochondrial membrane;nucleus;perinuclear region of cytoplasm;phagocytic cup;phagocytic vesicle membrane;photoreceptor inner segment;plasma membrane;postsynaptic density;postsynaptic membrane;protein complex;ruffle membrane;trans-Golgi network","Bacterial invasion of epithelial cells;Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Fc gamma R-mediated phagocytosis;Phospholipase D signaling pathway;Synaptic vesicle cycle",null,null,6,6,6,"10.1","10.1","10.1","98.063",0,"13.785",212000000,18,"0.0368084","0.95707","-0.131358","-0.115303","sp|P50570|DYN2_HUMAN;tr|K7EPK9|K7EPK9_HUMAN;tr|K7EMQ3|K7EMQ3_HUMAN;tr|E5RIK2|E5RIK2_HUMAN;tr|E5RHK8|E5RHK8_HUMAN;sp|Q9UQ16|DYN3_HUMAN","sp|P50570|DYN2_HUMAN",1118,"P50570","DYN2_HUMAN","Dynamin-2",null,"DNM2"]
["17.3958","17.3122","17.68","17.2912",{"$nulls":3},"nucleocytoplasmic transport","structural constituent of nuclear pore","nuclear pore",{"$nulls":3},4,4,4,"4.3","4.3","4.3","148.09",0,"9.3456",91643000,11,"0.239497","0.786789","-0.131613","-0.661884","tr|E9PF10|E9PF10_HUMAN;sp|O75694|NU155_HUMAN","tr|E9PF10|E9PF10_HUMAN;sp|O75694|NU155_HUMAN",362,"E9PF10","E9PF10_HUMAN",null,null,"NUP155"]
["20.1355","20.019","20.4071","20.0114",{"$nulls":5},"nuclear body;nucleoplasm",{"$nulls":3},2,2,2,"20.5","20.5","20.5","20.424",0,"4.9168",88850000,12,"0.230867","0.792034","-0.131993","-0.640069","tr|E9PPB5|E9PPB5_HUMAN;tr|E9PQS1|E9PQS1_HUMAN;tr|A0A087WT99|A0A087WT99_HUMAN;sp|Q9H0W9|CK054_HUMAN;tr|E9PR95|E9PR95_HUMAN;tr|E9PSC3|E9PSC3_HUMAN;tr|E9PLC5|E9PLC5_HUMAN;tr|E9PLB3|E9PLB3_HUMAN;tr|E9PIP1|E9PIP1_HUMAN;tr|E9PJU8|E9PJU8_HUMAN","tr|E9PPB5|E9PPB5_HUMAN;tr|E9PQS1|E9PQS1_HUMAN;tr|A0A087WT99|A0A087WT99_HUMAN;sp|Q9H0W9|CK054_HUMAN;tr|E9PR95|E9PR95_HUMAN;tr|E9PSC3|E9PSC3_HUMAN;tr|E9PLC5|E9PLC5_HUMAN;tr|E9PLB3|E9PLB3_HUMAN;tr|E9PIP1|E9PIP1_HUMAN;tr|E9PJU8|E9PJU8_HUMAN",2565,"E9PPB5","E9PPB5_HUMAN",null,null,"C11orf54"]
["19.6073","17.5904","19.7674","17.6966",{"$nulls":3},"biosynthetic process","nucleotidyltransferase activity","cytoplasm;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Fructose and mannose metabolism;Metabolic pathways",null,null,2,2,2,"6.9","6.9","6.9","46.291",0,"13.136",126020000,13,"0.0291925","0.966695","-0.133159","-0.0921312","sp|Q96IJ6|GMPPA_HUMAN;tr|A0A087WUI8|A0A087WUI8_HUMAN","sp|Q96IJ6|GMPPA_HUMAN;tr|A0A087WUI8|A0A087WUI8_HUMAN",2297,"Q96IJ6","GMPPA_HUMAN","Mannose-1-phosphate guanyltransferase alpha",null,"GMPPA"]
["19.6991","19.3682","19.8068","19.5287",{"$nulls":3},"regulation of cell adhesion;regulation of signaling","metal ion binding","integral component of membrane",{"$nulls":3},2,2,2,"2.1","2.1","2.1","145.42",0,"4.3356",484070000,5,"0.223029","0.800818","-0.13403","-0.620207","tr|E9PMS6|E9PMS6_HUMAN;tr|A0A0A0MTE2|A0A0A0MTE2_HUMAN;tr|E9PMT2|E9PMT2_HUMAN;tr|F8WD26|F8WD26_HUMAN;tr|J3KP06|J3KP06_HUMAN;sp|Q8WWI1|LMO7_HUMAN","tr|E9PMS6|E9PMS6_HUMAN;tr|A0A0A0MTE2|A0A0A0MTE2_HUMAN;tr|E9PMT2|E9PMT2_HUMAN;tr|F8WD26|F8WD26_HUMAN;tr|J3KP06|J3KP06_HUMAN;sp|Q8WWI1|LMO7_HUMAN",2150,"E9PMS6","E9PMS6_HUMAN",null,null,"LMO7"]
["18.4827","18.6457","19.0419","18.3557",{"$nulls":4},"N-acetyltransferase activity",{"$nulls":4},2,2,2,"17.8","17.8","17.8","18.057",0,"5.1245",33271000,15,"0.131135","0.898869","-0.134635","-0.381772","tr|G3V4W4|G3V4W4_HUMAN;sp|Q96EK6|GNA1_HUMAN;tr|G3V5E4|G3V5E4_HUMAN","tr|G3V4W4|G3V4W4_HUMAN;sp|Q96EK6|GNA1_HUMAN;tr|G3V5E4|G3V5E4_HUMAN",2261,"G3V4W4","G3V4W4_HUMAN",null,null,"GNPNAT1"]
["23.3665","22.8501","23.4805","23.0061",{"$nulls":3},"aging;cellular response to amino acid starvation;cellular response to heat;cellular response to UV;negative regulation of guanyl-nucleotide exchange factor activity;negative regulation of translational initiation in response to stress;PERK-mediated unfolded protein response;positive regulation of neuron death;positive regulation of type B pancreatic cell apoptotic process;protein autophosphorylation;response to endoplasmic reticulum stress;response to manganese-induced endoplasmic reticulum stress;translational initiation;transmembrane transport","ribosome binding;RNA binding;translation initiation factor activity","cytoplasmic stress granule;cytosol;eukaryotic 48S preinitiation complex;eukaryotic translation initiation factor 2 complex;extracellular exosome;glial limiting end-foot;membrane;multi-eIF complex;nucleus;polysome;ribosome;translation initiation ternary complex","Apoptosis;Autophagy - animal;Hepatitis C;Herpes simplex virus 1 infection;Influenza A;Measles;Non-alcoholic fatty liver disease (NAFLD);Protein processing in endoplasmic reticulum;RNA transport",null,null,16,16,16,53,53,53,"36.112",0,"76.174",1903800000,75,"0.132323","0.898504","-0.134966","-0.38495","sp|P05198|IF2A_HUMAN;tr|G3V4T5|G3V4T5_HUMAN;tr|H0YJS4|H0YJS4_HUMAN","sp|P05198|IF2A_HUMAN;tr|G3V4T5|G3V4T5_HUMAN;tr|H0YJS4|H0YJS4_HUMAN",517,"P05198","IF2A_HUMAN","Eukaryotic translation initiation factor 2 subunit 1",null,"EIF2S1"]
["25.3597","25.2689","25.7682","25.1332",{"$nulls":3},"chloride transport;platelet aggregation;positive regulation of osteoblast differentiation;regulation of cell cycle;regulation of ion transmembrane transport;regulation of mitochondrial membrane potential;signal transduction","cadherin binding;chloride channel activity;voltage-gated ion channel activity","blood microparticle;brush border;chloride channel complex;cytoplasm;extracellular exosome;extracellular space;membrane;mitochondrion;nuclear envelope;nuclear membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;vesicle",{"$nulls":3},10,10,10,56,56,56,"26.922",0,"323.31",5949300000,86,"0.147469","0.876778","-0.136369","-0.42518","sp|O00299|CLIC1_HUMAN","sp|O00299|CLIC1_HUMAN",134,"O00299","CLIC1_HUMAN","Chloride intracellular channel protein 1",null,"CLIC1"]
["22.07","21.7786","22.1319","21.9908",{"$nulls":4},"dolichyl-diphosphooligosaccharide-protein glycotransferase activity","integral component of membrane;oligosaccharyltransferase complex",{"$nulls":3},1,1,1,"18.5","18.5","18.5","7.2883",0,"4.6734",77566000,9,"0.313154","0.714284","-0.137106","-0.846892","tr|F5H895|F5H895_HUMAN;tr|A0A0B4J239|A0A0B4J239_HUMAN;tr|F5GXX5|F5GXX5_HUMAN;sp|P61803|DAD1_HUMAN","tr|F5H895|F5H895_HUMAN;tr|A0A0B4J239|A0A0B4J239_HUMAN;tr|F5GXX5|F5GXX5_HUMAN;sp|P61803|DAD1_HUMAN",1281,"F5H895","F5H895_HUMAN",null,null,"DAD1"]
["20.7376","20.8602","21.2725","20.5996",{"$nulls":3},"alpha-linolenic acid metabolic process;androgen metabolic process;bile acid biosynthetic process;estrogen metabolic process;fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA oxidase;medium-chain fatty-acyl-CoA metabolic process;osteoblast differentiation;Sertoli cell development;very long-chain fatty acid metabolic process;very long-chain fatty-acyl-CoA metabolic process","17-beta-hydroxysteroid dehydrogenase (NAD+) activity;3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity;3-hydroxyacyl-CoA dehydrogenase activity;isomerase activity;long-chain-enoyl-CoA hydratase activity;protein homodimerization activity;receptor binding","membrane;mitochondrion;peroxisomal matrix;peroxisomal membrane;peroxisome","Biosynthesis of unsaturated fatty acids;Fatty acid metabolism;Metabolic pathways;Peroxisome;Primary bile acid biosynthesis",null,null,11,11,11,"23.9","23.9","23.9","79.685",0,"88.484",660130000,57,"0.138329","0.889794","-0.13712","-0.400961","sp|P51659|DHB4_HUMAN;tr|E7EWE5|E7EWE5_HUMAN;tr|E7ER27|E7ER27_HUMAN;tr|G5E9S2|G5E9S2_HUMAN;tr|E7ET17|E7ET17_HUMAN;tr|E7EPL9|E7EPL9_HUMAN","sp|P51659|DHB4_HUMAN;tr|E7EWE5|E7EWE5_HUMAN;tr|E7ER27|E7ER27_HUMAN;tr|G5E9S2|G5E9S2_HUMAN;tr|E7ET17|E7ET17_HUMAN",1144,"P51659","DHB4_HUMAN","Peroxisomal multifunctional enzyme type 2","FE-2","HSD17B4"]
["21.9941","21.9003","22.9867","21.182",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;autophagosome assembly;bone resorption;early endosome to late endosome transport;endocytosis;endosome to lysosome transport;epidermal growth factor catabolic process;lipid catabolic process;lipophagy;multi-organism intracellular transport;negative regulation of exosomal secretion;negative regulation of intralumenal vesicle formation;neutrophil degranulation;phagosome acidification;phagosome maturation;phagosome-lysosome fusion;positive regulation of exosomal secretion;positive regulation of protein catabolic process;positive regulation of viral process;protein targeting to lysosome;protein to membrane docking;protein transport;retrograde transport, endosome to Golgi;viral release from host cell","GDP binding;GTP binding;GTPase activity;Rac GTPase binding;retromer complex binding","alveolar lamellar body;autophagosome membrane;cytosol;endosome membrane;extracellular exosome;extrinsic component of lysosome membrane;Golgi apparatus;late endosome;late endosome membrane;lipid droplet;lysosomal membrane;lysosome;melanosome membrane;phagocytic vesicle;phagocytic vesicle membrane;phagophore assembly site membrane;plasma membrane;secretory granule membrane;terminal bouton","Amoebiasis;Autophagy - animal;Endocytosis;Mitophagy - animal;Phagosome;Salmonella infection;Tuberculosis",null,null,7,7,7,"41.1","41.1","41.1","23.489",0,"119.67",627710000,27,"0.0490056","0.952895","-0.137136","-0.151772","sp|P51149|RAB7A_HUMAN;tr|C9J8S3|C9J8S3_HUMAN;tr|C9IZZ0|C9IZZ0_HUMAN;tr|C9J592|C9J592_HUMAN;tr|C9J4V0|C9J4V0_HUMAN;tr|C9J4S4|C9J4S4_HUMAN","sp|P51149|RAB7A_HUMAN;tr|C9J8S3|C9J8S3_HUMAN;tr|C9IZZ0|C9IZZ0_HUMAN;tr|C9J592|C9J592_HUMAN",1131,"P51149","RAB7A_HUMAN","Ras-related protein Rab-7a",null,"RAB7A"]
["16.2267","16.1439","17.0156","15.6303",{"$nulls":3},"acrosome reaction;animal organ morphogenesis;cell differentiation;cornified envelope assembly;ectoderm development;intracellular protein transport;protein oligomerization;regulation of blood coagulation;response to hydroperoxide;signal transduction;synaptic vesicle fusion to presynaptic active zone membrane;vesicle docking","calcium-dependent protein binding;protein dimerization activity;SNAP receptor activity;SNARE binding","basolateral plasma membrane;extracellular exosome;extracellular space;integral component of membrane;intracellular membrane-bounded organelle;lamellipodium;plasma membrane;SNARE complex;synaptic vesicle","SNARE interactions in vesicular transport;Synaptic vesicle cycle",null,null,1,1,1,"4.9","4.9","4.9","33.341","0.00075386","2.8445",13193000,2,"0.0649358","0.937291","-0.137622","-0.198327","sp|P32856|STX2_HUMAN","sp|P32856|STX2_HUMAN",906,"P32856","STX2_HUMAN","Syntaxin-2",null,"STX2"]
["19.0725","18.88","19.487","18.7409",{"$nulls":3},"cellular response to ionizing radiation;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;double-strand break repair;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of peptidyl-serine phosphorylation;positive regulation of peptidyl-threonine phosphorylation;positive regulation of protein autophosphorylation;telomere maintenance via telomerase","ankyrin repeat binding;cadherin binding;enzyme binding;macromolecular complex binding","CCR4-NOT complex;cell-cell adherens junction;cytoplasm;cytoskeleton;cytosol;nuclear heterochromatin;nucleus",{"$nulls":3},19,19,19,"20.6","20.6","20.6","181.79",0,"125.42",402390000,62,"0.122089","0.901895","-0.137717","-0.35747","sp|Q9C0C2|TB182_HUMAN;tr|E9PKE7|E9PKE7_HUMAN;tr|E9PKK0|E9PKK0_HUMAN","sp|Q9C0C2|TB182_HUMAN",2530,"Q9C0C2","TB182_HUMAN","182 kDa tankyrase-1-binding protein",null,"TNKS1BP1"]
["18.8121","18.6226","19.0923","18.6181",{"$nulls":3},"carbohydrate catabolic process;deoxyribonucleoside catabolic process;deoxyribonucleotide catabolic process;deoxyribose phosphate catabolic process;neutrophil degranulation;pentose-phosphate shunt","deoxyribose-phosphate aldolase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleus;secretory granule lumen","Metabolic pathways;Pentose phosphate pathway",null,null,4,4,4,"18.6","18.6","18.6","35.23",0,"35.299",101580000,17,"0.191637","0.83031","-0.137901","-0.540099","sp|Q9Y315|DEOC_HUMAN;tr|E9PML7|E9PML7_HUMAN;tr|E9PPM8|E9PPM8_HUMAN;tr|G3V158|G3V158_HUMAN;tr|E9PJ44|E9PJ44_HUMAN;tr|E9PJB9|E9PJB9_HUMAN;tr|E9PMH9|E9PMH9_HUMAN","sp|Q9Y315|DEOC_HUMAN;tr|E9PML7|E9PML7_HUMAN;tr|E9PPM8|E9PPM8_HUMAN;tr|G3V158|G3V158_HUMAN",2969,"Q9Y315","DEOC_HUMAN","Deoxyribose-phosphate aldolase","ERA","DERA"]
["20.2025","20.0163","20.3764","20.1207",{"$nulls":3},"blastocyst development;cellular response to amino acid stimulus;extracellular matrix disassembly;myoblast fusion;protein autoprocessing;proteolysis;proteolysis involved in cellular protein catabolic process;regulation of cytoskeleton organization;response to hypoxia","calcium ion binding;calcium-dependent cysteine-type endopeptidase activity;cysteine-type peptidase activity;cytoskeletal protein binding;protein heterodimerization activity","chromatin;cortical actin cytoskeleton;cytoplasm;cytosol;dendrite;endoplasmic reticulum;extracellular exosome;focal adhesion;Golgi apparatus;lysosome;membrane raft;nucleus;perinuclear endoplasmic reticulum;plasma membrane;pseudopodium","Alzheimer disease;Apoptosis;Cellular senescence;Focal adhesion;Necroptosis;Protein processing in endoplasmic reticulum",null,null,9,9,9,18,18,18,"79.994",0,"73.367",460980000,54,"0.326327","0.706198","-0.139174","-0.879932","sp|P17655|CAN2_HUMAN","sp|P17655|CAN2_HUMAN",709,"P17655","CAN2_HUMAN","Calpain-2 catalytic subunit",null,"CAPN2"]
["20.9717","20.9809","21.1707","21.0605",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;COPII vesicle coating;ER to Golgi vesicle-mediated transport;negative regulation of autophagosome assembly;positive regulation of protein catabolic process;protein transport;retrograde vesicle-mediated transport, Golgi to ER;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;vesicle fusion with Golgi apparatus","SNAP receptor activity;SNARE binding;syntaxin binding","endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;ER to Golgi transport vesicle membrane;Golgi membrane;integral component of membrane;melanosome;phagocytic vesicle membrane;SNARE complex;transport vesicle","Legionellosis;Phagosome;SNARE interactions in vesicular transport",null,null,6,6,6,"34.4","34.4","34.4","24.593",0,"32.402",335070000,26,"0.892289","0.300802","-0.139284","-2.51749","sp|O75396|SC22B_HUMAN;tr|A0A087X1A9|A0A087X1A9_HUMAN","sp|O75396|SC22B_HUMAN",341,"O75396","SC22B_HUMAN","Vesicle-trafficking protein SEC22b",null,"SEC22B"]
["15.5286","15.2179","16.0239","15.0015",{"$nulls":9},1,1,1,2,2,2,"83.069","0.00076982","3.016",12402000,3,"0.0869802","0.924912","-0.139463","-0.261012","sp|Q8IYQ7|THNS1_HUMAN","sp|Q8IYQ7|THNS1_HUMAN",2026,"Q8IYQ7","THNS1_HUMAN","Threonine synthase-like 1","SH1","THNSL1"]
["15.8566","15.5708","15.8427","15.864",{"$nulls":3},"cellular zinc ion homeostasis;nucleotide-excision repair;positive regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;zinc II ion transport","cation transmembrane transporter activity;chromatin binding;DNA binding transcription factor activity;ligand-dependent nuclear receptor binding;ligand-dependent nuclear receptor transcription coactivator activity","cytoplasmic vesicle;cytoskeleton;endoplasmic reticulum;integral component of membrane;nucleus",{"$nulls":3},1,1,1,"1.6","1.6","1.6","63.514","0.0014025","2.2707",11985000,2,"0.363905","0.665721","-0.13967","-0.974455","sp|Q6PML9|ZNT9_HUMAN","sp|Q6PML9|ZNT9_HUMAN",1898,"Q6PML9","ZNT9_HUMAN","Zinc transporter 9","nT-9","SLC30A9"]
["19.226","19.1566","19.6882","18.9742",{"$nulls":3},"cell morphogenesis;hematopoietic stem cell proliferation;homeostasis of number of cells;mRNA splicing, via spliceosome;nucleosome assembly;positive regulation of histone deubiquitination;regulation of gene expression;spliceosomal snRNP assembly;spliceosomal tri-snRNP complex assembly","histone binding;RNA binding;U4 snRNA binding;U6 snRNA binding;U6atac snRNA binding;ubiquitin-specific protease binding","Cajal body;cytoplasm;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"9.1","9.1","9.1","109.93",0,"35.395",272380000,25,"0.134238","0.894974","-0.139913","-0.390064","sp|Q15020|SART3_HUMAN;tr|F8VV04|F8VV04_HUMAN;tr|H0YHU8|H0YHU8_HUMAN","sp|Q15020|SART3_HUMAN;tr|F8VV04|F8VV04_HUMAN",1663,"Q15020","SART3_HUMAN","Squamous cell carcinoma antigen recognized by T-cells 3 {ECO:0000305}","ART-3 {ECO:0000312|EMBL:BAA78384.1}","SART3"]
["16.3126","16.438","16.6303","16.4002",{"$nulls":9},5,5,5,8,8,8,"114.43",0,"3.8012",50998000,5,"0.400859","0.621287","-0.139923","-1.06809","tr|A0A087WW77|A0A087WW77_HUMAN;sp|Q15334|L2GL1_HUMAN","tr|A0A087WW77|A0A087WW77_HUMAN;sp|Q15334|L2GL1_HUMAN",1691,"A0A087WW77","A0A087WW77_HUMAN",null,null,"LLGL1"]
["21.0632","20.9734","21.1119","21.2069",{"$nulls":3},"signal peptide processing","peptidase activity","integral component of membrane;signal peptidase complex",{"$nulls":3},2,2,2,31,31,31,"10.163",0,"24.43",88430000,10,"0.786263","0.332751","-0.141123","-2.15816","tr|E9PRB9|E9PRB9_HUMAN;tr|E9PL01|E9PL01_HUMAN;sp|Q15005|SPCS2_HUMAN;tr|A0A087WUC6|A0A087WUC6_HUMAN;tr|E9PI68|E9PI68_HUMAN","tr|E9PRB9|E9PRB9_HUMAN;tr|E9PL01|E9PL01_HUMAN;sp|Q15005|SPCS2_HUMAN;tr|A0A087WUC6|A0A087WUC6_HUMAN;tr|E9PI68|E9PI68_HUMAN",1657,"E9PRB9","E9PRB9_HUMAN",null,null,"SPCS2"]
["24.6239","24.5606","25.002","24.4678",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of peptide antigen via MHC class I;cell redox homeostasis;positive regulation of extrinsic apoptotic signaling pathway;protein folding;protein folding in endoplasmic reticulum;protein import into nucleus;protein retention in ER lumen;response to endoplasmic reticulum stress;signal transduction","cysteine-type endopeptidase activity;disulfide oxidoreductase activity;identical protein binding;peptide disulfide oxidoreductase activity;phospholipase C activity;protein disulfide isomerase activity;RNA binding","cell surface;endoplasmic reticulum;endoplasmic reticulum lumen;extracellular exosome;extracellular space;focal adhesion;melanosome;myelin sheath;nucleus;phagocytic vesicle;recycling endosome membrane","Antigen processing and presentation;Epstein-Barr virus infection;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Protein processing in endoplasmic reticulum",null,null,22,22,17,"48.5","48.5","41.2","56.782",0,"323.31",8240200000,193,"0.187819","0.832146","-0.142639","-0.530282","sp|P30101|PDIA3_HUMAN","sp|P30101|PDIA3_HUMAN",865,"P30101","PDIA3_HUMAN","Protein disulfide-isomerase A3",null,"PDIA3"]
["17.2151","17.1681","17.6285","17.0405",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;protein targeting to lysosome","Rab GTPase binding","axon cytoplasm;clathrin adaptor complex;cytoplasmic vesicle membrane;Golgi apparatus;lysosomal membrane;lysosome","Lysosome",null,null,3,3,3,"14.8","14.8","14.8","46.939",0,"4.8895",41929000,6,"0.170053","0.851674","-0.142855","-0.484331","sp|Q9Y2T2|AP3M1_HUMAN","sp|Q9Y2T2|AP3M1_HUMAN",2957,"Q9Y2T2","AP3M1_HUMAN","AP-3 complex subunit mu-1",null,"AP3M1"]
["18.772","18.5908","19.0757","18.5731",{"$nulls":4},"oxidoreductase activity",{"$nulls":4},2,2,2,"15.5","15.5","15.5","19.943","0.00038595","3.0628",46984000,6,"0.18973","0.830766","-0.142964","-0.535198","tr|H3BMS6|H3BMS6_HUMAN;tr|H3BNX3|H3BNX3_HUMAN;sp|Q9Y6N5|SQRD_HUMAN;tr|A0A0K0K1E6|A0A0K0K1E6_HUMAN;tr|H3BV36|H3BV36_HUMAN","tr|H3BMS6|H3BMS6_HUMAN;tr|H3BNX3|H3BNX3_HUMAN;sp|Q9Y6N5|SQRD_HUMAN;tr|A0A0K0K1E6|A0A0K0K1E6_HUMAN;tr|H3BV36|H3BV36_HUMAN",3056,"H3BMS6","H3BMS6_HUMAN",null,null,"SQOR"]
["19.1284","19.0071","19.7909","18.6316",{"$nulls":3},"steroid biosynthetic process","fatty-acyl-CoA binding;protein kinase A regulatory subunit binding","Golgi apparatus;Golgi membrane;membrane;mitochondrion",{"$nulls":3},4,4,4,"15.9","15.9","15.9","60.593",0,"41.507",141760000,22,"0.0817293","0.928887","-0.143518","-0.246247","sp|Q9H3P7|GCP60_HUMAN","sp|Q9H3P7|GCP60_HUMAN",2590,"Q9H3P7","GCP60_HUMAN","Golgi resident protein GCP60",null,"ACBD3"]
["20.4636","20.1816","20.5156","20.4179",{"$nulls":3},"camera-type eye development;gluconeogenesis;glycerol catabolic process;glycerophosphate shuttle;multicellular organism growth","calcium ion binding;glycerol-3-phosphate dehydrogenase activity;sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity","glycerol-3-phosphate dehydrogenase complex;mitochondrial inner membrane","Glycerophospholipid metabolism",null,null,10,10,10,"24.2","24.2","24.2","80.852",0,"18.972",507380000,43,"0.360481","0.66887","-0.144148","-0.965818","sp|P43304|GPDM_HUMAN;tr|F5GYK7|F5GYK7_HUMAN","sp|P43304|GPDM_HUMAN",1008,"P43304","GPDM_HUMAN","Glycerol-3-phosphate dehydrogenase, mitochondrial","PDH-M;PD-M","GPD2"]
["15.7987","15.7841","17.0034","14.8678",{"$nulls":3},"adipose tissue development;cellular response to cholesterol;cellular response to glucose stimulus;cellular response to testosterone stimulus;fatty acid metabolic process;ketone body biosynthetic process;liver development;positive regulation of insulin secretion;response to drug;response to ethanol;response to nutrient;response to oleic acid;response to purine-containing compound;response to starvation;white fat cell differentiation","acetoacetate-CoA ligase activity;ATP binding;butyrate-CoA ligase activity","cytosol","Butanoate metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,2,2,2,"3.7","3.7","3.7","75.143",0,"4.9699",28709000,7,"0.043362","0.954241","-0.14415","-0.134992","sp|Q86V21|AACS_HUMAN","sp|Q86V21|AACS_HUMAN",1983,"Q86V21","AACS_HUMAN","Acetoacetyl-CoA synthetase",null,"AACS"]
["16.6651","16.7733","17.3251","16.4033",{"$nulls":3},"cellular response to lipopolysaccharide;endodermal cell fate commitment;histone H2B ubiquitination;histone monoubiquitination;mRNA polyadenylation;negative regulation of myeloid cell differentiation;negative regulation of transcription from RNA polymerase II promoter;nucleosome positioning;positive regulation of cell cycle G1/S phase transition;positive regulation of histone methylation;positive regulation of mRNA 3'-end processing;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein localization to nucleus;protein ubiquitination;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;Wnt signaling pathway","chromatin binding;RNA polymerase II core binding","Cdc73/Paf1 complex;cell junction;cytoplasm;membrane;nucleoplasm",{"$nulls":3},2,2,2,4,4,4,"59.975",0,"9.4217",32326000,4,"0.105559","0.912658","-0.14502","-0.312514","sp|Q8N7H5|PAF1_HUMAN;tr|B4DGJ5|B4DGJ5_HUMAN","sp|Q8N7H5|PAF1_HUMAN;tr|B4DGJ5|B4DGJ5_HUMAN",2064,"Q8N7H5","PAF1_HUMAN","RNA polymerase II-associated factor 1 homolog","PAF1","PAF1"]
["16.7374","17.1341","16.6561","17.5087",{"$nulls":3},"apoptotic process;cardiac muscle contraction;cardiac right ventricle morphogenesis;embryonic camera-type eye development;hair cycle;multicellular organism growth;multicellular organismal homeostasis;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell differentiation;post-embryonic development;regulation of signal transduction by p53 class mediator;transcription, DNA-templated;ventricular cardiac muscle tissue development","cadherin binding;identical protein binding;transcription corepressor activity;transcription factor binding","cell junction;cytosol;intercellular bridge;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"13.4","13.4","13.4","89.09",0,"8.8793",57809000,10,"0.1053","0.91258","-0.146605","-0.311803","sp|Q8WUF5|IASPP_HUMAN;tr|K7EN03|K7EN03_HUMAN","sp|Q8WUF5|IASPP_HUMAN",2138,"Q8WUF5","IASPP_HUMAN","RelA-associated inhibitor",null,"PPP1R13L"]
["15.5879","14.888","15.6993","15.0705",{"$nulls":9},1,1,1,"2.4","2.4","2.4","66.318","0.00038956","3.1347",7442400,3,"0.10548","0.91251","-0.146926","-0.312297","tr|H7C2C4|H7C2C4_HUMAN;tr|H7C1N2|H7C1N2_HUMAN;tr|J3KR05|J3KR05_HUMAN;sp|O75128|COBL_HUMAN","tr|H7C2C4|H7C2C4_HUMAN;tr|H7C1N2|H7C1N2_HUMAN;tr|J3KR05|J3KR05_HUMAN;sp|O75128|COBL_HUMAN",320,"H7C2C4","H7C2C4_HUMAN",null,null,"COBL"]
["22.1937","22.3418","22.5874","22.2427",{"$nulls":3},"regulation of apoptotic process;regulation of mRNA stability","cadherin binding;mRNA 3'-UTR binding;RNA binding","cytoplasm;cytosol;extracellular exosome;membrane;nucleus;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},7,7,7,"20.6","20.6","20.6","44.965",0,"54.728",824380000,32,"0.288526","0.742929","-0.147303","-0.78515","sp|Q8NC51|PAIRB_HUMAN","sp|Q8NC51|PAIRB_HUMAN",2079,"Q8NC51","PAIRB_HUMAN","Plasminogen activator inhibitor 1 RNA-binding protein",null,"SERBP1"]
["24.1168","23.9722","24.4355","23.9488",{"$nulls":4},"DNA binding","nucleus",{"$nulls":3},3,3,3,"25.5","25.5","25.5","17.522",0,"8.614",923250000,20,"0.207826","0.814971","-0.147635","-0.581538","tr|E9PES6|E9PES6_HUMAN;tr|E7ES08|E7ES08_HUMAN;tr|E7EQU1|E7EQU1_HUMAN;sp|O15347|HMGB3_HUMAN","tr|E9PES6|E9PES6_HUMAN;tr|E7ES08|E7ES08_HUMAN;tr|E7EQU1|E7EQU1_HUMAN;sp|O15347|HMGB3_HUMAN",214,"E9PES6","E9PES6_HUMAN",null,null,"HMGB3"]
["18.2029","18.3214","19.2456","17.5743",{"$nulls":4},"metal ion binding;superoxide dismutase activity",{"$nulls":4},1,1,1,"19.1","19.1","19.1","7.2852","0.0011207","2.7779",29601000,6,"0.0574014","0.945462","-0.147826","-0.17645","tr|E9PP76|E9PP76_HUMAN;tr|J3KNF4|J3KNF4_HUMAN;sp|O14618|CCS_HUMAN","tr|E9PP76|E9PP76_HUMAN;tr|J3KNF4|J3KNF4_HUMAN;sp|O14618|CCS_HUMAN",164,"E9PP76","E9PP76_HUMAN",null,null,"CCS"]
["19.3927","19.1614","19.2014","19.6507",{"$nulls":3},"brain development;G1 to G0 transition;kidney development;lung development;negative regulation of epithelial cell proliferation;negative regulation of translation;organonitrogen compound catabolic process;response to lipid;response to salt","deaminase activity;endoribonuclease activity, producing 3'-phosphomonoesters;long-chain fatty acid binding;platinum binding;protein homodimerization activity;RNA binding;transition metal ion binding;xenon atom binding","cytoplasm;cytosol;extracellular exosome;mitochondrial matrix;nucleus;peroxisome",{"$nulls":3},2,2,2,"25.5","25.5","25.5","14.494",0,"23.084",44125000,8,"0.211029","0.812947","-0.149006","-0.589704","sp|P52758|UK114_HUMAN;tr|H0YBX3|H0YBX3_HUMAN;tr|H0YB34|H0YB34_HUMAN","sp|P52758|UK114_HUMAN;tr|H0YBX3|H0YBX3_HUMAN;tr|H0YB34|H0YB34_HUMAN",1165,"P52758","RIDA_HUMAN","2-iminobutanoate/2-iminopropanoate deaminase {ECO:0000305|PubMed:22094463}",null,"RIDA"]
["18.5547","18.4169","18.6445","18.6254",{"$nulls":4},"phosphatase binding",{"$nulls":4},4,4,4,"14.4","14.4","14.4","68.041",0,"22.056",71215000,15,"0.781773","0.334339","-0.149125","-2.14366","tr|A0A0G2JHC2|A0A0G2JHC2_HUMAN;sp|Q6NYC8|PPR18_HUMAN","tr|A0A0G2JHC2|A0A0G2JHC2_HUMAN;sp|Q6NYC8|PPR18_HUMAN",1878,"A0A0G2JHC2","A0A0G2JHC2_HUMAN",null,null,"PPP1R18"]
["19.2755","19.0243","19.2913","19.3073",{"$nulls":3},"mRNA splicing, via spliceosome",{"$nulls":5},2,2,2,22,22,22,"17.541",0,"10.922",51297000,13,"0.447304","0.554025","-0.149406","-1.18726","tr|E9PQI8|E9PQI8_HUMAN;sp|O43290|SNUT1_HUMAN","tr|E9PQI8|E9PQI8_HUMAN;sp|O43290|SNUT1_HUMAN",239,"E9PQI8","E9PQI8_HUMAN",null,null,"SART1"]
["22.1939","22.6423","23.0335","22.1021",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},3,3,3,"28.2","28.2","28.2","14.558",0,"11.335",426630000,16,"0.0972492","0.91674","-0.149693","-0.289614","tr|E7EPB3|E7EPB3_HUMAN;sp|P50914|RL14_HUMAN","tr|E7EPB3|E7EPB3_HUMAN;sp|P50914|RL14_HUMAN",1123,"E7EPB3","E7EPB3_HUMAN",null,null,"RPL14"]
["19.2566","18.2268","18.6952","19.0877",{"$nulls":3},"apoptotic process;autophagy;cellular response to cobalt ion;cellular response to DNA damage stimulus;cellular response to hypoxia;fructose 1,6-bisphosphate metabolic process;fructose 2,6-bisphosphate metabolic process;intestinal epithelial cell development;negative regulation of glucose catabolic process to lactate via pyruvate;negative regulation of glycolytic process;negative regulation of mitophagy;negative regulation of neuron death;negative regulation of programmed cell death;negative regulation of reactive oxygen species metabolic process;positive regulation of cardiac muscle cell apoptotic process;positive regulation of DNA repair;positive regulation of hexokinase activity;regulation of pentose-phosphate shunt;regulation of response to DNA damage checkpoint signaling;response to gamma radiation;response to ischemia;response to xenobiotic stimulus","bisphosphoglycerate 2-phosphatase activity;fructose-2,6-bisphosphate 2-phosphatase activity","cytoplasm;cytosol;intracellular;mitochondrial outer membrane;nucleus","Central carbon metabolism in cancer;Fructose and mannose metabolism;Metabolic pathways",null,null,1,1,1,"6.3","6.3","6.3","30.062","0.00039968","3.3607",65166000,8,"0.0908117","0.920267","-0.14973","-0.271725","sp|Q9NQ88|TIGAR_HUMAN","sp|Q9NQ88|TIGAR_HUMAN",2666,"Q9NQ88","TIGAR_HUMAN","Fructose-2,6-bisphosphatase TIGAR {ECO:0000305}",null,"TIGAR"]
["16.523","16.2777","16.9992","16.1012",{"$nulls":3},"ER-associated misfolded protein catabolic process;regulation of apoptotic process","ATPase binding;chaperone binding;dolichyl-phosphate-mannose-protein mannosyltransferase activity;misfolded protein binding","endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;endoplasmic reticulum membrane",{"$nulls":3},1,1,1,"10.9","10.9","10.9","23.598",0,"10.75",13151000,4,"0.108987","0.909958","-0.149832","-0.321899","sp|Q9HCN8|SDF2L_HUMAN","sp|Q9HCN8|SDF2L_HUMAN",2647,"Q9HCN8","SDF2L_HUMAN","Stromal cell-derived factor 2-like protein 1","DF2-like protein 1","SDF2L1"]
["19.1222","19.1431","19.3234","19.243",{"$nulls":3},"alternative mRNA splicing, via spliceosome;cellular response to exogenous dsRNA;cellular response to tumor necrosis factor;CRD-mediated mRNA stabilization;DNA duplex unwinding;DNA replication;DNA-templated transcription, termination;DNA-templated viral transcription;G-quadruplex DNA unwinding;inflammatory response;innate immune response;mRNA splicing, via spliceosome;mRNA transport;osteoblast differentiation;positive regulation of cytoplasmic translation;positive regulation of DNA repair;positive regulation of DNA replication;positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;positive regulation of fibroblast proliferation;positive regulation of gene silencing by miRNA;positive regulation of inflammatory response;positive regulation of innate immune response;positive regulation of interferon-alpha secretion;positive regulation of interferon-beta secretion;positive regulation of interleukin-18 production;positive regulation of interleukin-6 secretion;positive regulation of NF-kappaB transcription factor activity;positive regulation of polysome binding;positive regulation of response to cytokine stimulus;positive regulation of RNA export from nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor secretion;positive regulation of type I interferon production;positive regulation of viral transcription;positive regulation of viral translation;protein localization to cytoplasmic stress granule;pyroptosis;regulation of cytoplasmic translation;regulation of defense response to virus by host;regulation of mRNA processing;regulation of transcription from RNA polymerase II promoter;rhythmic process;RNA processing;RNA secondary structure unwinding;small RNA loading onto RISC;targeting of mRNA for destruction involved in RNA interference","ATP binding;ATPase activity;ATP-dependent 3'-5' DNA helicase activity;ATP-dependent 3'-5' DNA/RNA helicase activity;ATP-dependent 3'-5' RNA helicase activity;ATP-dependent DNA helicase activity;ATP-dependent RNA helicase activity;chromatin DNA binding;core promoter binding;DNA binding;DNA replication origin binding;double-stranded DNA binding;double-stranded RNA binding;importin-alpha family protein binding;metal ion binding;mRNA binding;nucleoside-triphosphatase activity;nucleoside-triphosphate diphosphatase activity;polysome binding;promoter-specific chromatin binding;regulatory region RNA binding;RISC complex binding;RNA binding;RNA helicase activity;RNA polymerase binding;RNA polymerase II core binding;RNA polymerase II transcription coactivator activity;RNA polymerase II transcription cofactor activity;RNA polymerase II transcription factor binding;RNA stem-loop binding;sequence-specific mRNA binding;single-stranded DNA binding;single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity;single-stranded RNA binding;siRNA binding;triplex DNA binding","actin cytoskeleton;centrosome;CRD-mediated mRNA stability complex;cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;intracellular ribonucleoprotein complex;membrane;micro-ribonucleoprotein complex;nuclear body;nuclear stress granule;nucleolus;nucleoplasm;nucleus;perichromatin fibrils;polysomal ribosome;polysome;protein complex;RISC-loading complex",{"$nulls":3},10,10,10,"13.1","13.1","13.1","140.96",0,"21.598",308100000,35,"1.16541","0.314214","-0.150597","-3.62674","sp|Q08211|DHX9_HUMAN","sp|Q08211|DHX9_HUMAN",1470,"Q08211","DHX9_HUMAN","ATP-dependent RNA helicase A {ECO:0000305}",null,"DHX9"]
["18.9472","19.2181","18.6901","19.7778",{"$nulls":3},"interleukin-12-mediated signaling pathway;negative regulation of cyclic-nucleotide phosphodiesterase activity;protein maturation by protein folding;protein targeting to mitochondrion;regulation of protein kinase A signaling;xenobiotic metabolic process","aryl hydrocarbon receptor binding;GAF domain binding;signal transducer activity;transcription coactivator activity;transcription factor binding;unfolded protein binding","aryl hydrocarbon receptor complex;cytoplasm;cytosol;membrane;nucleoplasm","Cushing syndrome",null,null,4,4,4,"18.5","18.5","18.5","37.636",0,"35.042",101870000,14,"0.0901689","0.9219","-0.151298","-0.269931","sp|O00170|AIP_HUMAN;tr|E9PMH2|E9PMH2_HUMAN;tr|V9GYQ3|V9GYQ3_HUMAN","sp|O00170|AIP_HUMAN;tr|E9PMH2|E9PMH2_HUMAN;tr|V9GYQ3|V9GYQ3_HUMAN",122,"O00170","AIP_HUMAN","AH receptor-interacting protein","IP","AIP"]
["20.0526","19.7571","20.2648","19.8485",{"$nulls":3},"activation of store-operated calcium channel activity;cellular calcium ion homeostasis;detection of calcium ion;enamel mineralization;positive regulation of angiogenesis;regulation of calcium ion transport;regulation of cardiac conduction;regulation of store-operated calcium entry;store-operated calcium entry","calcium channel regulator activity;calcium ion binding;identical protein binding;microtubule plus-end binding;protease binding","cortical endoplasmic reticulum;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;integral component of plasma membrane;microtubule;plasma membrane;sarcoplasmic reticulum membrane","Calcium signaling pathway;Platelet activation",null,null,8,8,8,"15.9","15.9","15.9","77.422",0,"73.227",356160000,37,"0.212946","0.809","-0.151763","-0.594586","sp|Q13586|STIM1_HUMAN;tr|E9PNJ4|E9PNJ4_HUMAN;tr|G0XQ39|G0XQ39_HUMAN;tr|H0YDB2|H0YDB2_HUMAN","sp|Q13586|STIM1_HUMAN;tr|E9PNJ4|E9PNJ4_HUMAN;tr|G0XQ39|G0XQ39_HUMAN;tr|H0YDB2|H0YDB2_HUMAN",1575,"Q13586","STIM1_HUMAN","Stromal interaction molecule 1",null,"STIM1"]
["26.3053","26.5744","26.7494","26.4352",{"$nulls":3},"cell aging;cellular response to UV;CENP-A containing nucleosome assembly;centrosome cycle;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA repair;intracellular protein transport;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of centrosome duplication;negative regulation of protein kinase activity by regulation of protein phosphorylation;nucleocytoplasmic transport;nucleosome assembly;positive regulation of cell cycle G2/M phase transition;positive regulation of cell proliferation;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of translation;protein localization;protein oligomerization;regulation of centriole replication;regulation of eIF2 alpha phosphorylation by dsRNA;regulation of endodeoxyribonuclease activity;regulation of endoribonuclease activity;regulation of transcription from RNA polymerase II promoter;response to stress;ribosome assembly;signal transduction;viral process","activating transcription factor binding;core promoter binding;histone binding;NF-kappaB binding;protein heterodimerization activity;protein homodimerization activity;protein kinase binding;protein kinase inhibitor activity;ribosomal large subunit binding;ribosomal small subunit binding;RNA binding;RNA polymerase II transcription coactivator activity;Tat protein binding;transcription coactivator activity;transcription factor binding;unfolded protein binding","centrosome;cytoplasm;cytosol;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;spindle pole centrosome",{"$nulls":3},10,10,10,"42.5","42.5","42.5","32.575",0,"323.31",9764700000,105,"0.269243","0.756378","-0.152418","-0.736765","sp|P06748|NPM_HUMAN;tr|E5RI98|E5RI98_HUMAN;tr|E5RGW4|E5RGW4_HUMAN","sp|P06748|NPM_HUMAN",536,"P06748","NPM_HUMAN","Nucleophosmin","PM","NPM1"]
["16.134","16.5215","16.0731","16.8874",{"$nulls":3},"chromatin assembly or disassembly",null,"nucleolus;nucleus",{"$nulls":3},2,2,2,"5.8","5.8","5.8","61.956","0.00075873","2.8896",19218000,1,"0.114985","0.903675","-0.1525","-0.338241","sp|Q9BW71|HIRP3_HUMAN","sp|Q9BW71|HIRP3_HUMAN",2479,"Q9BW71","HIRP3_HUMAN","HIRA-interacting protein 3",null,"HIRIP3"]
["18.0538","17.9643","18.0036","18.3202",{"$nulls":3},"small GTPase mediated signal transduction","GTP binding","Golgi apparatus",{"$nulls":3},2,2,2,"22.2","22.2","22.2","15.443",0,"4.9977",21789000,9,"0.345875","0.688207","-0.152839","-0.92904","tr|B4DZG7|B4DZG7_HUMAN;sp|P40616|ARL1_HUMAN;tr|F8W1Z8|F8W1Z8_HUMAN;tr|F8VYN9|F8VYN9_HUMAN","tr|B4DZG7|B4DZG7_HUMAN;sp|P40616|ARL1_HUMAN;tr|F8W1Z8|F8W1Z8_HUMAN;tr|F8VYN9|F8VYN9_HUMAN",971,"B4DZG7","B4DZG7_HUMAN",null,null,"ARL1"]
["18.4096","18.4566","18.4315","18.7439",{"$nulls":5},"cytosol;nucleoplasm;plasma membrane",{"$nulls":3},4,4,4,10,10,10,"63.779",0,"42.347",95433000,17,"0.365647","0.663575","-0.154612","-0.978849","tr|H0YEN2|H0YEN2_HUMAN;tr|E9PQP7|E9PQP7_HUMAN;tr|H7BXH2|H7BXH2_HUMAN;tr|E9PKF6|E9PKF6_HUMAN;sp|Q5H9R7|PP6R3_HUMAN","tr|H0YEN2|H0YEN2_HUMAN;tr|E9PQP7|E9PQP7_HUMAN;tr|H7BXH2|H7BXH2_HUMAN;tr|E9PKF6|E9PKF6_HUMAN;sp|Q5H9R7|PP6R3_HUMAN",1807,"H0YEN2","H0YEN2_HUMAN",null,null,"PPP6R3"]
["18.961","18.9373","18.4919","19.7177",{"$nulls":4},"DNA binding",{"$nulls":4},4,4,4,"13.7","13.7","13.7","39.871",0,"12.657",129860000,18,"0.0844694","0.925766","-0.155677","-0.253964","tr|B4DEM9|B4DEM9_HUMAN;sp|Q9Y2S7|PDIP2_HUMAN","tr|B4DEM9|B4DEM9_HUMAN;sp|Q9Y2S7|PDIP2_HUMAN",2956,"B4DEM9","B4DEM9_HUMAN",null,null,"POLDIP2"]
["21.7374","21.5964","22.2138","21.4319",{"$nulls":3},"cardiolipin acyl-chain remodeling;fatty acid beta-oxidation;response to drug;response to insulin","3-hydroxyacyl-CoA dehydrogenase activity;acetyl-CoA C-acetyltransferase activity;enoyl-CoA hydratase activity;fatty-acyl-CoA binding;long-chain-3-hydroxyacyl-CoA dehydrogenase activity;long-chain-enoyl-CoA hydratase activity;NAD binding;protein complex binding","extracellular matrix;mitochondrial fatty acid beta-oxidation multienzyme complex;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrion","beta-Alanine metabolism;Butanoate metabolism;Carbon metabolism;Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Lysine degradation;Metabolic pathways;Propanoate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,18,18,18,"34.6","34.6","34.6","82.999",0,"184.39",1326300000,106,"0.135187","0.894134","-0.155967","-0.392595","sp|P40939|ECHA_HUMAN;tr|H0YFD6|H0YFD6_HUMAN","sp|P40939|ECHA_HUMAN",978,"P40939","ECHA_HUMAN","Trifunctional enzyme subunit alpha, mitochondrial",null,"HADHA"]
["13.4348","12.7774","13.8405","12.6843",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitinyl hydrolase activity","nucleoplasm",{"$nulls":3},1,1,1,"0.5","0.5","0.5","294.36","0.00076599","2.9824",14497000,6,"0.0777744","0.930481","-0.156308","-0.23506","sp|Q9UPU5|UBP24_HUMAN","sp|Q9UPU5|UBP24_HUMAN",2926,"Q9UPU5","UBP24_HUMAN","Ubiquitin carboxyl-terminal hydrolase 24",null,"USP24"]
["24.5235","24.4815","24.8066","24.5112",{"$nulls":3},"canonical glycolysis;cellular response to hypoxia;epithelial cell differentiation;gluconeogenesis;glycolytic process;negative regulation of angiogenesis;phosphorylation;plasminogen activation","ATP binding;phosphoglycerate kinase activity;protein-disulfide reductase activity","cytosol;extracellular exosome;extracellular space;membrane;membrane raft","Biosynthesis of amino acids;Carbon metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways",null,null,16,16,16,59,59,59,"44.614",0,"264.91",6640100000,145,"0.393065","0.62664","-0.156382","-1.04827","sp|P00558|PGK1_HUMAN;sp|P07205|PGK2_HUMAN","sp|P00558|PGK1_HUMAN",473,"P00558","PGK1_HUMAN","Phosphoglycerate kinase 1",null,"PGK1"]
["22.2037","21.9882","22.2406","22.2645",{"$nulls":3},"cell redox homeostasis;cellular response to oxidative stress;cellular response to reactive oxygen species;hydrogen peroxide catabolic process;maternal placenta development;mitochondrion organization;myeloid cell differentiation;negative regulation of apoptotic process;negative regulation of kinase activity;peptidyl-cysteine oxidation;positive regulation of cell proliferation;positive regulation of NF-kappaB transcription factor activity;regulation of mitochondrial membrane potential;response to hydrogen peroxide;response to lipopolysaccharide;response to oxidative stress","alkyl hydroperoxide reductase activity;cysteine-type endopeptidase inhibitor activity involved in apoptotic process;identical protein binding;kinase binding;protein C-terminus binding;protein kinase binding;thioredoxin peroxidase activity","cytoplasm;cytosol;early endosome;extracellular exosome;mitochondrial matrix;mitochondrion;myelin sheath;protein complex",{"$nulls":3},5,5,5,"25.8","25.8","25.8","27.692",0,"15.205",611380000,34,"0.544558","0.484636","-0.156622","-1.44471","sp|P30048|PRDX3_HUMAN","sp|P30048|PRDX3_HUMAN",859,"P30048","PRDX3_HUMAN","Thioredoxin-dependent peroxide reductase, mitochondrial",null,"PRDX3"]
["21.3976","21.239","21.6061","21.344",{"$nulls":5},"integral component of membrane;nuclear membrane",{"$nulls":3},8,8,8,"27.9","27.9","27.9","52.406",0,"60.081",628700000,35,"0.38318","0.636313","-0.156728","-1.02319","tr|A0A0A0MSK5|A0A0A0MSK5_HUMAN;sp|Q5JTV8|TOIP1_HUMAN;tr|J3KN66|J3KN66_HUMAN;tr|H0Y4R4|H0Y4R4_HUMAN;tr|H0YD16|H0YD16_HUMAN;tr|H0YDU3|H0YDU3_HUMAN","tr|A0A0A0MSK5|A0A0A0MSK5_HUMAN;sp|Q5JTV8|TOIP1_HUMAN;tr|J3KN66|J3KN66_HUMAN;tr|H0Y4R4|H0Y4R4_HUMAN;tr|H0YD16|H0YD16_HUMAN",1814,"A0A0A0MSK5","A0A0A0MSK5_HUMAN",null,null,"TOR1AIP1"]
["24.4716","24.3412","24.6933","24.4333",{"$nulls":3},"carbohydrate metabolic process;fructose 6-phosphate metabolic process;interleukin-12-mediated signaling pathway;pentose-phosphate shunt;pentose-phosphate shunt, non-oxidative branch;xylulose biosynthetic process","monosaccharide binding;sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity","cytoplasm;cytosol;extracellular exosome;nucleus","Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,10,10,10,32,32,32,"37.54",0,"69.519",3745300000,34,"0.404964","0.61505","-0.156857","-1.07855","sp|P37837|TALDO_HUMAN;tr|F2Z393|F2Z393_HUMAN","sp|P37837|TALDO_HUMAN;tr|F2Z393|F2Z393_HUMAN",955,"P37837","TALDO_HUMAN","Transaldolase",null,"TALDO1"]
["21.3111","21.1003","21.4858","21.2398",{"$nulls":9},2,2,2,"17.3","17.3","17.3","18.262",0,"25.076",166620000,13,"0.361998","0.668757","-0.157049","-0.969643","tr|A0A0C4DG56|A0A0C4DG56_HUMAN;tr|A0A0C4DFU2|A0A0C4DFU2_HUMAN;sp|P04179|SODM_HUMAN;tr|F5H3C5|F5H3C5_HUMAN;tr|F5H4R2|F5H4R2_HUMAN;tr|A0A0C4DFU1|A0A0C4DFU1_HUMAN;tr|F5GYZ5|F5GYZ5_HUMAN","tr|A0A0C4DG56|A0A0C4DG56_HUMAN;tr|A0A0C4DFU2|A0A0C4DFU2_HUMAN;sp|P04179|SODM_HUMAN;tr|F5H3C5|F5H3C5_HUMAN;tr|F5H4R2|F5H4R2_HUMAN;tr|A0A0C4DFU1|A0A0C4DFU1_HUMAN;tr|F5GYZ5|F5GYZ5_HUMAN",493,"A0A0C4DG56"]
["23.6906","23.458","24.1579","23.3052",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;barbed-end actin filament capping;blood coagulation;cell junction assembly;ER to Golgi vesicle-mediated transport;innate immune response;interleukin-12-mediated signaling pathway;movement of cell or subcellular component;protein complex assembly","actin binding;cadherin binding","actin cytoskeleton;cytoskeleton;cytosol;extracellular exosome;extracellular region;F-actin capping protein complex;WASH complex","Endocytosis",null,null,9,9,8,"52.8","52.8","49.3","32.922",0,"134.22",1811200000,61,"0.121482","0.902422","-0.157253","-0.355832","sp|P52907|CAZA1_HUMAN","sp|P52907|CAZA1_HUMAN",1169,"P52907","CAZA1_HUMAN","F-actin-capping protein subunit alpha-1",null,"CAPZA1"]
["20.4227","20.4978","20.8076","20.4279",{"$nulls":3},"carnitine metabolic process;cellular organofluorine metabolic process;cellular response to follicle-stimulating hormone stimulus;cellular response to peptide hormone stimulus;demethylation;fatty acid oxidation;flavonoid metabolic process;internal peptidyl-lysine acetylation;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of lipase activity;nitrate catabolic process;nitric oxide catabolic process;oxidation-reduction process;positive regulation of cholesterol biosynthetic process;positive regulation of chondrocyte differentiation;positive regulation of monooxygenase activity;positive regulation of smoothened signaling pathway;positive regulation of steroid hormone biosynthetic process;regulation of growth plate cartilage chondrocyte proliferation;response to drug;response to nutrient;xenobiotic metabolic process","cytochrome-b5 reductase activity, acting on NAD(P)H;electron transfer activity;enzyme binding;flavin adenine dinucleotide binding;FMN binding;hydrolase activity;iron-cytochrome-c reductase activity;NADP binding;NADPH-hemoprotein reductase activity;nitric oxide dioxygenase activity","endoplasmic reticulum membrane;integral component of membrane;intracellular membrane-bounded organelle;membrane;mitochondrion",{"$nulls":3},13,13,13,"23.9","23.9","23.9","76.689",0,"34.53",644650000,51,"0.299908","0.729247","-0.157481","-0.813684","sp|P16435|NCPR_HUMAN;tr|H0Y4R2|H0Y4R2_HUMAN;tr|E7EMD0|E7EMD0_HUMAN;tr|E7EWU0|E7EWU0_HUMAN;tr|C9JU80|C9JU80_HUMAN","sp|P16435|NCPR_HUMAN;tr|H0Y4R2|H0Y4R2_HUMAN;tr|E7EMD0|E7EMD0_HUMAN",698,"P16435","NCPR_HUMAN","NADPH--cytochrome P450 reductase {ECO:0000255|HAMAP-Rule:MF_03212}","450R {ECO:0000255|HAMAP-Rule:MF_03212};PR {ECO:0000255|HAMAP-Rule:MF_03212}","POR"]
["26.6264","26.6542","27.3546","26.2414",{"$nulls":3},"establishment of Golgi localization;Golgi reassembly;membrane organization;negative regulation of apoptotic process;platelet activation;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein targeting;regulation of mRNA stability;signal transduction","cadherin binding;identical protein binding;ion channel binding;protein domain specific binding;protein kinase binding;RNA binding;transcription factor binding;ubiquitin protein ligase binding","blood microparticle;cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;extracellular space;focal adhesion;melanosome;mitochondrion;nucleoplasm;nucleus;vesicle","Cell cycle;Hepatitis B;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;Pathogenic Escherichia coli infection;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,14,10,10,58,"50.2","50.2","27.745",0,"323.31",15866000000,129,"0.0949183","0.919813","-0.157651","-0.283153","sp|P63104|1433Z_HUMAN;tr|E7EX29|E7EX29_HUMAN;tr|B0AZS6|B0AZS6_HUMAN;tr|B7Z2E6|B7Z2E6_HUMAN;tr|H0YB80|H0YB80_HUMAN;tr|E7ESK7|E7ESK7_HUMAN;tr|E5RGE1|E5RGE1_HUMAN;tr|E5RIR4|E5RIR4_HUMAN;tr|E9PD24|E9PD24_HUMAN;tr|E7EVZ2|E7EVZ2_HUMAN","sp|P63104|1433Z_HUMAN;tr|E7EX29|E7EX29_HUMAN;tr|B0AZS6|B0AZS6_HUMAN;tr|B7Z2E6|B7Z2E6_HUMAN;tr|H0YB80|H0YB80_HUMAN;tr|E7ESK7|E7ESK7_HUMAN",1341,"P63104","1433Z_HUMAN","14-3-3 protein zeta/delta",null,"YWHAZ"]
["21.7646","21.6838","22.2597","21.5045",{"$nulls":3},"ATP biosynthetic process;cristae formation;mitochondrial ATP synthesis coupled proton transport;oxidative phosphorylation","proton-transporting ATP synthase activity, rotational mechanism;RNA binding;transmembrane transporter activity","extracellular exosome;membrane;mitochondrial inner membrane;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);mitochondrion;myelin sheath","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,3,3,3,"11.1","11.1","11.1","32.996",0,"7.2356",460760000,18,"0.143932","0.880747","-0.157931","-0.415828","sp|P36542|ATPG_HUMAN","sp|P36542|ATPG_HUMAN",943,"P36542","ATPG_HUMAN","ATP synthase subunit gamma, mitochondrial",null,"ATP5C1"]
["18.9453","18.6224","19.6751","18.2092",{"$nulls":3},"activation of cysteine-type endopeptidase activity;activation of store-operated calcium channel activity;calcium ion transmembrane transport;cellular response to calcium ion;detection of calcium ion;face morphogenesis;ion transmembrane transport;limb morphogenesis;muscle contraction;negative regulation of cell proliferation;palate development;pattern specification process;peptidyl-aspartic acid hydroxylation;positive regulation of calcium ion transport into cytosol;positive regulation of intracellular protein transport;positive regulation of proteolysis;positive regulation of ryanodine-sensitive calcium-release channel activity;positive regulation of transcription, DNA-templated;regulation of cardiac conduction;regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;regulation of cell communication by electrical coupling;regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;regulation of protein depolymerization;regulation of protein stability;regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;regulation of ryanodine-sensitive calcium-release channel activity;response to ATP","calcium ion binding;electron transfer activity;ion channel binding;peptide-aspartate beta-dioxygenase activity;structural constituent of muscle;structural molecule activity","calcium channel complex;cell;cortical endoplasmic reticulum;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;integral component of membrane;junctional sarcoplasmic reticulum membrane;plasma membrane;sarcoplasmic reticulum lumen;sarcoplasmic reticulum membrane","Calcium signaling pathway;Cardiac muscle contraction",null,null,5,5,5,14,14,14,"85.862",0,"17.704",152070000,24,"0.0692949","0.935738","-0.158262","-0.210873","sp|Q12797|ASPH_HUMAN;tr|E5RG29|E5RG29_HUMAN;tr|A0A0A0MSK8|A0A0A0MSK8_HUMAN;tr|E5RG56|E5RG56_HUMAN;tr|E5RHJ2|E5RHJ2_HUMAN;tr|E5RHK2|E5RHK2_HUMAN;tr|G3XAN5|G3XAN5_HUMAN;tr|A0A087WUJ2|A0A087WUJ2_HUMAN","sp|Q12797|ASPH_HUMAN",1494,"Q12797","ASPH_HUMAN","Aspartyl/asparaginyl beta-hydroxylase",null,"ASPH"]
["18.0154","16.9848","17.9965","17.3211",{"$nulls":3},"cardiac muscle contraction;diaphragm contraction;glucose metabolic process;glycogen catabolic process;heart morphogenesis;locomotory behavior;lysosome organization;maltose metabolic process;muscle cell cellular homeostasis;neuromuscular process controlling balance;neuromuscular process controlling posture;neutrophil degranulation;regulation of the force of heart contraction;sucrose metabolic process;tissue development;vacuolar sequestering","alpha-1,4-glucosidase activity;carbohydrate binding;maltose alpha-glucosidase activity;oligo-1,6-glucosidase activity","azurophil granule membrane;extracellular exosome;ficolin-1-rich granule membrane;lysosomal lumen;lysosomal membrane;lysosome;membrane;plasma membrane;tertiary granule membrane","Galactose metabolism;Lysosome;Metabolic pathways;Starch and sucrose metabolism",null,null,3,3,3,"5.7","5.7","5.7","105.32",0,"11.615",80982000,17,"0.0857498","0.926068","-0.158676","-0.257561","sp|P10253|LYAG_HUMAN","sp|P10253|LYAG_HUMAN",605,"P10253","LYAG_HUMAN","Lysosomal alpha-glucosidase",null,"GAA"]
["18.9503","18.6848","19.5977","18.3589",{"$nulls":3},"androgen metabolic process;apoptotic signaling pathway;ceramide metabolic process;estrogen metabolic process;face morphogenesis;fatty acid metabolic process;fibroblast migration;hemopoiesis;kidney development;Leydig cell differentiation;luteinization;palate development;platelet-derived growth factor receptor signaling pathway;post-embryonic development;regulation of multicellular organism growth;skeletal system morphogenesis;spermatogenesis;sphingolipid biosynthetic process;sphingolipid catabolic process;vasculogenesis","carboxy-lyase activity;pyridoxal phosphate binding;sphinganine-1-phosphate aldolase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane","Metabolic pathways;Sphingolipid metabolism;Sphingolipid signaling pathway",null,null,5,5,5,"12.5","12.5","12.5","63.523",0,"11.439",148660000,19,"0.0843866","0.925583","-0.160728","-0.253731","sp|O95470|SGPL1_HUMAN;tr|H0Y3V8|H0Y3V8_HUMAN;tr|H7BXL7|H7BXL7_HUMAN","sp|O95470|SGPL1_HUMAN;tr|H0Y3V8|H0Y3V8_HUMAN;tr|H7BXL7|H7BXL7_HUMAN",437,"O95470","SGPL1_HUMAN","Sphingosine-1-phosphate lyase 1 {ECO:0000305}","1PL {ECO:0000305};PL 1 {ECO:0000305};P-lyase 1 {ECO:0000305};SPL","SGPL1"]
["20.879","20.8538","21.558","20.4987",{"$nulls":3},"chemical synaptic transmission",null,"extracellular exosome;integral component of membrane;integral component of plasma membrane;integral component of synaptic vesicle membrane;melanosome;secretory granule",{"$nulls":3},2,2,2,"13.9","13.9","13.9","28.565",0,"6.6712",195680000,25,"0.103068","0.91564","-0.161935","-0.305672","sp|Q16563|SYPL1_HUMAN;tr|C9JYN0|C9JYN0_HUMAN","sp|Q16563|SYPL1_HUMAN;tr|C9JYN0|C9JYN0_HUMAN",1744,"Q16563","SYPL1_HUMAN","Synaptophysin-like protein 1",null,"SYPL1"]
["21.8555","21.8997","22.169","21.9104",{"$nulls":3},"diadenosine tetraphosphate biosynthetic process;mitochondrial glycyl-tRNA aminoacylation;tRNA aminoacylation for protein translation","ATP binding;bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;glycine-tRNA ligase activity;identical protein binding;protein dimerization activity","axon;cytoplasm;cytosol;extracellular exosome;mitochondrial matrix;mitochondrion;secretory granule","Aminoacyl-tRNA biosynthesis",null,null,15,15,15,"31.5","31.5","31.5","83.165",0,"323.31",1726500000,93,"0.466064","0.53621","-0.162145","-1.236","sp|P41250|SYG_HUMAN;tr|H7C443|H7C443_HUMAN","sp|P41250|SYG_HUMAN",985,"P41250","GARS_HUMAN","Glycine--tRNA ligase",null,"GARS"]
["19.979","20.0675","20.2691","20.102",{"$nulls":3},"fatty acid beta-oxidation","flavin adenine dinucleotide binding;medium-chain-acyl-CoA dehydrogenase activity","mitochondrion;nuclear speck",{"$nulls":3},5,5,5,"17.1","17.1","17.1","42.426",0,"17.568",164720000,27,"0.641767","0.402876","-0.162325","-1.71678","tr|B7Z9I1|B7Z9I1_HUMAN;sp|P11310|ACADM_HUMAN;tr|Q5T4U5|Q5T4U5_HUMAN;tr|E9PRX4|E9PRX4_HUMAN;tr|E9PJM9|E9PJM9_HUMAN","tr|B7Z9I1|B7Z9I1_HUMAN;sp|P11310|ACADM_HUMAN;tr|Q5T4U5|Q5T4U5_HUMAN",629,"B7Z9I1","B7Z9I1_HUMAN",null,null,"ACADM"]
["16.7623","16.924","17.2844","16.7279",{"$nulls":3},"Golgi ribbon formation;late endosome to Golgi transport;microtubule anchoring;microtubule organizing center organization;protein localization to Golgi apparatus;protein targeting to lysosome;recycling endosome to Golgi transport;regulation of protein exit from endoplasmic reticulum;retrograde transport, endosome to Golgi","identical protein binding","cytosol;Golgi apparatus;membrane;nucleoplasm;trans-Golgi network",{"$nulls":3},5,5,5,4,4,4,"195.91",0,"31.156",126130000,10,"0.200322","0.821198","-0.162957","-0.562367","sp|Q8IWJ2|GCC2_HUMAN;tr|A0A087WZR8|A0A087WZR8_HUMAN;tr|B8ZZW2|B8ZZW2_HUMAN;tr|U3KQE0|U3KQE0_HUMAN;tr|U3KPU4|U3KPU4_HUMAN","sp|Q8IWJ2|GCC2_HUMAN;tr|A0A087WZR8|A0A087WZR8_HUMAN;tr|B8ZZW2|B8ZZW2_HUMAN",2014,"Q8IWJ2","GCC2_HUMAN","GRIP and coiled-coil domain-containing protein 2",null,"GCC2"]
["21.5025","21.5712","21.9683","21.4322",{"$nulls":3},"circadian rhythm;G-protein coupled receptor signaling pathway","heme binding","cytoplasm;extracellular exosome;extracellular region",{"$nulls":3},7,7,7,"41.8","41.8","41.8","21.097",0,"48.599",414300000,28,"0.216842","0.8025","-0.163376","-0.604497","sp|Q9NRV9|HEBP1_HUMAN;tr|F5GWX2|F5GWX2_HUMAN;tr|H0YG71|H0YG71_HUMAN","sp|Q9NRV9|HEBP1_HUMAN;tr|F5GWX2|F5GWX2_HUMAN",2683,"Q9NRV9","HEBP1_HUMAN","Heme-binding protein 1",null,"HEBP1"]
["22.2739","22.2874","22.3785","22.5096",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent ERAD pathway;ubiquitin-dependent protein catabolic process;Wnt signaling pathway, planar cell polarity pathway","ATP binding;ATPase activity;identical protein binding;proteasome-activating ATPase activity;protein binding, bridging;TBP-class protein binding","cytosol;cytosolic proteasome complex;extracellular exosome;membrane;nuclear proteasome complex;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, base subcomplex","Epstein-Barr virus infection;Proteasome",null,null,10,10,10,35,35,35,"44.172",0,"50.962",1172900000,45,"0.881808","0.302329","-0.163454","-2.48043","sp|P62333|PRS10_HUMAN;tr|A0A087X2I1|A0A087X2I1_HUMAN;tr|H0YJC0|H0YJC0_HUMAN;tr|H0YJS8|H0YJS8_HUMAN;tr|H0YJX2|H0YJX2_HUMAN;tr|H0YJE9|H0YJE9_HUMAN;tr|H0YJT1|H0YJT1_HUMAN","sp|P62333|PRS10_HUMAN;tr|A0A087X2I1|A0A087X2I1_HUMAN;tr|H0YJC0|H0YJC0_HUMAN",1306,"P62333","PRS10_HUMAN","26S proteasome regulatory subunit 10B",null,"PSMC6"]
["18.9253","18.8893","19.5922","18.5494",{"$nulls":3},"mRNA splicing, via spliceosome;nuclear import;protein complex assembly;regulation of translation;spliceosomal snRNP assembly;translation","mRNA 3'-UTR binding;ribosome binding;RNA 7-methylguanosine cap binding;RNA binding;snRNA binding;U1 snRNA binding;U4 snRNA binding;U4atac snRNA binding","cytoplasm;cytosol;Gemini of coiled bodies;membrane;nuclear body;nucleoplasm;SMN complex;SMN-Gemin2 complex;SMN-Sm protein complex","RNA transport",null,null,11,11,11,"10.8","10.8","10.8","168.59",0,"69.916",536490000,50,"0.105911","0.913504","-0.163541","-0.313478","sp|Q8TEQ6|GEMI5_HUMAN","sp|Q8TEQ6|GEMI5_HUMAN",2127,"Q8TEQ6","GEMI5_HUMAN","Gem-associated protein 5","emin5","GEMIN5"]
["23.967","23.8459","24.2064","23.9349",{"$nulls":3},"actin rod assembly;ATF6-mediated unfolded protein response;cellular protein metabolic process;cellular response to ATP;negative regulation of apoptotic process;post-translational protein modification;protein folding in endoplasmic reticulum;protein transport;receptor-mediated endocytosis;regulation of phosphoprotein phosphatase activity;response to endoplasmic reticulum stress;response to hypoxia;retrograde protein transport, ER to cytosol;sequestering of calcium ion;toll-like receptor signaling pathway;ubiquitin-dependent ERAD pathway","ATP binding;calcium ion binding;low-density lipoprotein particle receptor binding;protein phosphatase binding;RNA binding;unfolded protein binding","cytosol;endocytic vesicle lumen;endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular exosome;extracellular matrix;extracellular region;focal adhesion;melanosome;membrane;midbody;nucleus;perinuclear region of cytoplasm;plasma membrane;protein complex","Estrogen signaling pathway;Fluid shear stress and atherosclerosis;IL-17 signaling pathway;Pathways in cancer;PI3K-Akt signaling pathway;Prostate cancer;Protein processing in endoplasmic reticulum;Thyroid hormone synthesis",null,null,30,29,29,"41.1","39.6","39.6","92.468",0,"265.3",6930700000,191,"0.415134","0.600504","-0.164147","-1.10452","sp|P14625|ENPL_HUMAN;tr|Q96GW1|Q96GW1_HUMAN;sp|Q58FF3|ENPLL_HUMAN;tr|H0YIV0|H0YIV0_HUMAN;tr|F8W026|F8W026_HUMAN","sp|P14625|ENPL_HUMAN",671,"P14625","ENPL_HUMAN","Endoplasmin",null,"HSP90B1"]
["19.3418","18.9936","19.83","18.8339",{"$nulls":3},"membrane organization;phosphatidylcholine acyl-chain remodeling;platelet activating factor biosynthetic process","1-acylglycerol-3-phosphate O-acyltransferase activity;1-acylglycerophosphocholine O-acyltransferase activity;1-alkylglycerophosphocholine O-acetyltransferase activity;2-acylglycerol-3-phosphate O-acyltransferase activity;calcium ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane;Golgi stack;integral component of membrane;lipid droplet","Ether lipid metabolism;Glycerophospholipid metabolism;Metabolic pathways",null,null,4,4,4,"9.6","9.6","9.6","60.207",0,"9.3441",177030000,14,"0.105109","0.91258","-0.16423","-0.311278","sp|Q7L5N7|PCAT2_HUMAN;tr|H3BU68|H3BU68_HUMAN;tr|A0A087X0A3|A0A087X0A3_HUMAN","sp|Q7L5N7|PCAT2_HUMAN;tr|H3BU68|H3BU68_HUMAN;tr|A0A087X0A3|A0A087X0A3_HUMAN",1935,"Q7L5N7","PCAT2_HUMAN","Lysophosphatidylcholine acyltransferase 2","PC acyltransferase 2;PCAT-2;ysoPC acyltransferase 2","LPCAT2"]
["23.0423","22.7615","23.1239","23.0087",{"$nulls":3},"cristae formation;mitochondrial calcium ion homeostasis","RNA binding","membrane;MICOS complex;mitochondrial inner membrane;mitochondrion;myelin sheath",{"$nulls":3},23,23,3,"41.4","41.4","8.3","83.677",0,"172.73",3232900000,105,"0.40682","0.611568","-0.164404","-1.08328","sp|Q16891|MIC60_HUMAN;tr|B9A067|B9A067_HUMAN;tr|D6RAW4|D6RAW4_HUMAN","sp|Q16891|MIC60_HUMAN;tr|B9A067|B9A067_HUMAN",1763,"Q16891","MIC60_HUMAN","MICOS complex subunit MIC60",null,"IMMT"]
["21.0849","20.5133","21.2273","20.701",{"$nulls":4},"actin binding;ATP binding;motor activity","myosin complex",{"$nulls":3},11,11,11,"15.6","15.6","15.6","106.01",0,"38.087",970070000,45,"0.147382","0.876599","-0.16509","-0.42495","tr|K7EIG7|K7EIG7_HUMAN;sp|O94832|MYO1D_HUMAN;tr|J3QRN6|J3QRN6_HUMAN;tr|J3KRL0|J3KRL0_HUMAN","tr|K7EIG7|K7EIG7_HUMAN;sp|O94832|MYO1D_HUMAN;tr|J3QRN6|J3QRN6_HUMAN",394,"K7EIG7","K7EIG7_HUMAN",null,null,"MYO1D"]
["15.4917","15.5965","16.0464","15.3742",{"$nulls":3},"regulation of GTPase activity;signal transduction",{"$nulls":5},1,1,1,"1.9","1.9","1.9","77.741",0,"5.1863",23540000,1,"0.171706","0.850303","-0.166214","-0.488625","tr|H0Y638|H0Y638_HUMAN;sp|Q9UJF2|NGAP_HUMAN","tr|H0Y638|H0Y638_HUMAN;sp|Q9UJF2|NGAP_HUMAN",2857,"H0Y638","H0Y638_HUMAN",null,null,"RASAL2"]
["15.8036","15.3042","16.3671","15.0747",{"$nulls":3},"cell redox homeostasis;peptidyl-cysteine oxidation;platelet degranulation;protein folding;response to endoplasmic reticulum stress","protein disulfide isomerase activity;thiol oxidase activity","cell surface;endoplasmic reticulum membrane;integral component of membrane;plasma membrane;platelet alpha granule membrane",{"$nulls":3},1,1,1,"4.2","4.2","4.2","51.871",0,"3.4694",12407000,4,"0.0798832","0.92868","-0.166969","-0.241032","sp|Q96JJ7|TMX3_HUMAN","sp|Q96JJ7|TMX3_HUMAN",2308,"Q96JJ7","TMX3_HUMAN","Protein disulfide-isomerase TMX3",null,"TMX3"]
["18.53","18.6941","18.8349","18.7259",{"$nulls":3},"androgen metabolic process;estrogen biosynthetic process;fatty acid biosynthetic process;fatty-acyl-CoA biosynthetic process;oxidation-reduction process;protein heterotetramerization","3-hydroxyacyl-CoA dehydrogenase activity;3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity;estradiol 17-beta-dehydrogenase activity;NADH binding;testosterone dehydrogenase (NAD+) activity","mitochondrial envelope;mitochondrial matrix;plasma membrane","Fatty acid biosynthesis;Fatty acid metabolism;Metabolic pathways;Steroid hormone biosynthesis",null,null,1,1,1,5,5,5,"26.973",0,"22.264",41774000,9,"0.639224","0.404925","-0.168316","-1.70944","sp|Q92506|DHB8_HUMAN","sp|Q92506|DHB8_HUMAN",2165,"Q92506","DHB8_HUMAN","Estradiol 17-beta-dehydrogenase 8",null,"HSD17B8"]
["20.3542","20.2744","20.721","20.2462",{"$nulls":3},"mitotic DNA replication checkpoint;neuron apoptotic process;post-translational protein modification;protein neddylation;regulation of apoptotic process;regulation of neuron apoptotic process;signal transduction","NEDD8 activating enzyme activity;protein heterodimerization activity;ubiquitin protein ligase binding","cytoplasm;cytosol;plasma membrane","Alzheimer disease",null,null,8,8,8,"22.5","22.5","22.5","60.246",0,"134.94",299760000,36,"0.255937","0.768582","-0.169314","-0.703318","sp|Q13564|ULA1_HUMAN;tr|J3KTE3|J3KTE3_HUMAN;tr|J3QLH4|J3QLH4_HUMAN;tr|J3QRA5|J3QRA5_HUMAN;tr|J3KRK3|J3KRK3_HUMAN","sp|Q13564|ULA1_HUMAN",1572,"Q13564","ULA1_HUMAN","NEDD8-activating enzyme E1 regulatory subunit",null,"NAE1"]
["22.9226","22.335","23.1279","22.4684",{"$nulls":3},"chondrocyte development involved in endochondral bone morphogenesis;collagen biosynthetic process;collagen fibril organization;protein maturation;response to unfolded protein","collagen binding;RNA binding;serine-type endopeptidase inhibitor activity;unfolded protein binding","endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;membrane raft",{"$nulls":3},10,10,10,"35.2","35.2","35.2","46.44",0,"170.48",2009400000,63,"0.131764","0.897647","-0.169352","-0.383454","sp|P50454|SERPH_HUMAN;tr|E9PR70|E9PR70_HUMAN;tr|E9PPV6|E9PPV6_HUMAN;tr|E9PNX1|E9PNX1_HUMAN;tr|E9PK86|E9PK86_HUMAN;tr|E9PMI5|E9PMI5_HUMAN;tr|E9PJH8|E9PJH8_HUMAN;tr|E9PIG2|E9PIG2_HUMAN;tr|E9PRS3|E9PRS3_HUMAN;tr|E9PKH2|E9PKH2_HUMAN;tr|E9PQ34|E9PQ34_HUMAN;tr|E9PLA6|E9PLA6_HUMAN;tr|H0YEP8|H0YEP8_HUMAN","sp|P50454|SERPH_HUMAN;tr|E9PR70|E9PR70_HUMAN;tr|E9PPV6|E9PPV6_HUMAN;tr|E9PNX1|E9PNX1_HUMAN;tr|E9PK86|E9PK86_HUMAN;tr|E9PMI5|E9PMI5_HUMAN",1114,"P50454","SERPH_HUMAN","Serpin H1",null,"SERPINH1"]
["21.1153","20.96","21.5792","20.8352",{"$nulls":4},"GTP binding;GTPase activity",{"$nulls":4},21,21,21,"25.3","25.3","25.3","138.68",0,"112.71",1084600000,79,"0.155438","0.87112","-0.169545","-0.446157","tr|A0A087WUT6|A0A087WUT6_HUMAN;sp|O60841|IF2P_HUMAN","tr|A0A087WUT6|A0A087WUT6_HUMAN;sp|O60841|IF2P_HUMAN",310,"A0A087WUT6","A0A087WUT6_HUMAN",null,null,"EIF5B"]
[1,"20.3306",1,"20.6697",{"$nulls":3},"tRNA processing",null,"EKC/KEOPS complex;nuclear body;nucleoplasm",{"$nulls":3},1,1,1,"16.1","16.1","16.1","14.804",0,"3.8413",41246000,5,"0.00379246","0.991595","-0.169556","-0.0122963","sp|Q14657|LAGE3_HUMAN","sp|Q14657|LAGE3_HUMAN",1634,"Q14657","LAGE3_HUMAN","EKC/KEOPS complex subunit LAGE3",null,"LAGE3"]
["18.6885","18.2697","18.8012","18.4967",{"$nulls":9},1,1,1,6,6,6,"22.463","0.0053512","1.8803",26032000,3,"0.237181","0.788427","-0.169836","-0.656033","tr|M0QZI4|M0QZI4_HUMAN;sp|Q8IV08|PLD3_HUMAN","tr|M0QZI4|M0QZI4_HUMAN;sp|Q8IV08|PLD3_HUMAN",2006,"M0QZI4"]
["23.856","23.5397","23.9275","23.8079",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","identical protein binding;threonine-type endopeptidase activity","cytosol;extracellular exosome;nucleoplasm;nucleus;postsynapse;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex","Proteasome",null,null,7,7,7,"35.9","35.9","35.9","27.887",0,"50.69",1931800000,37,"0.37578","0.647507","-0.169863","-1.00445","sp|O14818|PSA7_HUMAN;tr|H0Y586|H0Y586_HUMAN;sp|Q8TAA3|PSA7L_HUMAN;tr|A0A087WYS6|A0A087WYS6_HUMAN;tr|F5GY34|F5GY34_HUMAN","sp|O14818|PSA7_HUMAN;tr|H0Y586|H0Y586_HUMAN",175,"O14818","PSA7_HUMAN","Proteasome subunit alpha type-7",null,"PSMA7"]
["22.6636","22.5563","22.9251","22.6346",{"$nulls":3},"fatty acid beta-oxidation using acyl-CoA dehydrogenase;respiratory electron transport chain","electron transfer activity;flavin adenine dinucleotide binding;oxidoreductase activity","extracellular exosome;mitochondrial matrix;mitochondrion",{"$nulls":3},8,8,8,36,36,36,"35.079",0,"141.67",1115400000,58,"0.412431","0.602821","-0.169951","-1.09761","sp|P13804|ETFA_HUMAN;tr|H0YL12|H0YL12_HUMAN;tr|H0YLU7|H0YLU7_HUMAN;tr|H0YK49|H0YK49_HUMAN;tr|H0YNX6|H0YNX6_HUMAN;tr|H0YKF0|H0YKF0_HUMAN;tr|H0YL83|H0YL83_HUMAN","sp|P13804|ETFA_HUMAN;tr|H0YL12|H0YL12_HUMAN;tr|H0YLU7|H0YLU7_HUMAN;tr|H0YK49|H0YK49_HUMAN;tr|H0YNX6|H0YNX6_HUMAN;tr|H0YKF0|H0YKF0_HUMAN",664,"P13804","ETFA_HUMAN","Electron transfer flavoprotein subunit alpha, mitochondrial","lpha-ETF","ETFA"]
["19.7442","19.656","19.8826","19.858",{"$nulls":3},"cellular response to amino acid stimulus;negative regulation of cyclin-dependent protein serine/threonine kinase activity;NLS-bearing protein import into nucleus;positive regulation of protein import into nucleus;protein import into nucleus, translocation;ribosomal protein import into nucleus;viral process","GTPase inhibitor activity;nuclear localization sequence binding;protein transporter activity;Ran GTPase binding;RNA binding","cytoplasm;membrane;nuclear membrane;nuclear periphery;nuclear pore;nucleolus;nucleus",{"$nulls":3},15,15,15,"22.8","22.8","22.8","123.63",0,"74.876",580390000,65,"1.18515","0.321789","-0.170227","-3.71926","sp|O00410|IPO5_HUMAN;tr|H0Y8C6|H0Y8C6_HUMAN;tr|E7ETV3|E7ETV3_HUMAN;tr|E7EQT5|E7EQT5_HUMAN;tr|C9JMV5|C9JMV5_HUMAN;tr|H0Y3V4|H0Y3V4_HUMAN;tr|C9JZD8|C9JZD8_HUMAN;tr|C9JZ53|C9JZ53_HUMAN;tr|E7EWK4|E7EWK4_HUMAN;tr|E7EX05|E7EX05_HUMAN;tr|E7EV12|E7EV12_HUMAN;tr|C9JXE0|C9JXE0_HUMAN;tr|C9J875|C9J875_HUMAN;tr|C9JQT6|C9JQT6_HUMAN;tr|E7ESA1|E7ESA1_HUMAN;tr|E7ESZ1|E7ESZ1_HUMAN;tr|E7ETV8|E7ETV8_HUMAN;sp|O60518|RNBP6_HUMAN","sp|O00410|IPO5_HUMAN;tr|H0Y8C6|H0Y8C6_HUMAN",138,"O00410","IPO5_HUMAN","Importin-5","mp5","IPO5"]
["18.4464","18.6513","19.1445","18.295",{"$nulls":3},"NAD biosynthesis via nicotinamide riboside salvage pathway;neutrophil degranulation;nicotinate nucleotide salvage;response to oxidative stress","ligase activity;nicotinate phosphoribosyltransferase activity;nicotinate-nucleotide diphosphorylase (carboxylating) activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region","Metabolic pathways;Nicotinate and nicotinamide metabolism",null,null,4,4,4,"11.7","11.7","11.7","57.578",0,"7.1306",71849000,6,"0.134602","0.894466","-0.170875","-0.391035","sp|Q6XQN6|PNCB_HUMAN;tr|G5E977|G5E977_HUMAN;tr|C9J8U2|C9J8U2_HUMAN;tr|A0A087WUT5|A0A087WUT5_HUMAN","sp|Q6XQN6|PNCB_HUMAN;tr|G5E977|G5E977_HUMAN;tr|C9J8U2|C9J8U2_HUMAN;tr|A0A087WUT5|A0A087WUT5_HUMAN",1910,"Q6XQN6","PNCB_HUMAN","Nicotinate phosphoribosyltransferase","APRTase","NAPRT"]
["24.2219","24.2321","24.8593","23.9368",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},6,6,6,"24.4","24.4","24.4","22.389",0,"38.201",1620800000,43,"0.127026","0.896761","-0.17103","-0.37076","tr|E9PKZ0|E9PKZ0_HUMAN;sp|P62917|RL8_HUMAN;tr|G3V1A1|G3V1A1_HUMAN;tr|E9PKU4|E9PKU4_HUMAN;tr|E9PP36|E9PP36_HUMAN","tr|E9PKZ0|E9PKZ0_HUMAN;sp|P62917|RL8_HUMAN;tr|G3V1A1|G3V1A1_HUMAN;tr|E9PKU4|E9PKU4_HUMAN;tr|E9PP36|E9PP36_HUMAN",1333,"E9PKZ0","E9PKZ0_HUMAN",null,null,"RPL8"]
["14.93","16.0404","15.7299","15.5828",{"$nulls":3},"cilium assembly;determination of left/right symmetry;heart development;intraciliary transport involved in cilium assembly;keratinocyte development;negative regulation of epithelial cell proliferation;non-motile cilium assembly;Notch signaling pathway;positive regulation of cell adhesion mediated by integrin;positive regulation of transcription from RNA polymerase II promoter","beta-tubulin binding;chromatin binding","centrosome;ciliary tip;cilium;cytoplasmic vesicle;intraciliary transport particle B;motile cilium;nucleus",{"$nulls":3},1,1,1,"2.3","2.3","2.3","69.239","0.0010589","2.3265",17948000,2,"0.103062","0.914908","-0.171186","-0.305653","sp|Q96LB3|IFT74_HUMAN","sp|Q96LB3|IFT74_HUMAN",2323,"Q96LB3","IFT74_HUMAN","Intraflagellar transport protein 74 homolog",null,"IFT74"]
["22.8275","22.7068","23.0343","22.8423",{"$nulls":4},"RNA binding","cytosol;nucleoplasm",{"$nulls":3},5,3,0,17,"10.7",0,"47.087",0,"40.448",1275400000,25,"0.568371","0.467399","-0.171205","-1.50981","tr|E9PCY7|E9PCY7_HUMAN;sp|P31943|HNRH1_HUMAN;tr|G8JLB6|G8JLB6_HUMAN;tr|H0YB39|H0YB39_HUMAN;tr|H0YBG7|H0YBG7_HUMAN;tr|H0YBD7|H0YBD7_HUMAN;tr|E5RGH4|E5RGH4_HUMAN;tr|E5RGV0|E5RGV0_HUMAN;tr|D6RIU0|D6RIU0_HUMAN;tr|D6RBM0|D6RBM0_HUMAN;tr|E7EQJ0|E7EQJ0_HUMAN;tr|D6RAM1|D6RAM1_HUMAN;tr|H0YAQ2|H0YAQ2_HUMAN;tr|D6R9T0|D6R9T0_HUMAN;tr|D6RFM3|D6RFM3_HUMAN;tr|D6RIT2|D6RIT2_HUMAN;tr|E7EN40|E7EN40_HUMAN;tr|D6RDU3|D6RDU3_HUMAN;tr|D6RJ04|D6RJ04_HUMAN;tr|D6RIH9|D6RIH9_HUMAN","tr|E9PCY7|E9PCY7_HUMAN;sp|P31943|HNRH1_HUMAN;tr|G8JLB6|G8JLB6_HUMAN;tr|H0YB39|H0YB39_HUMAN;tr|H0YBG7|H0YBG7_HUMAN;tr|H0YBD7|H0YBD7_HUMAN",895,"E9PCY7","E9PCY7_HUMAN",null,null,"HNRNPH1"]
["26.2558","25.8853","26.6475","25.8365",{"$nulls":3},"animal organ regeneration;cellular response to cell-matrix adhesion;cellular response to epidermal growth factor stimulus;cellular response to glucocorticoid stimulus;cellular response to insulin stimulus;cellular response to lipopolysaccharide;cellular response to oxidative stress;central nervous system development;common myeloid progenitor cell proliferation;glutathione derivative biosynthetic process;glutathione metabolic process;linoleic acid metabolic process;negative regulation of acute inflammatory response;negative regulation of apoptotic process;negative regulation of biosynthetic process;negative regulation of ERK1 and ERK2 cascade;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of fibroblast proliferation;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interleukin-1 beta production;negative regulation of JUN kinase activity;negative regulation of leukocyte proliferation;negative regulation of MAP kinase activity;negative regulation of MAPK cascade;negative regulation of monocyte chemotactic protein-1 production;negative regulation of nitric-oxide synthase biosynthetic process;negative regulation of protein kinase activity;negative regulation of smooth muscle cell chemotaxis;negative regulation of stress-activated MAPK cascade;negative regulation of tumor necrosis factor production;negative regulation of tumor necrosis factor-mediated signaling pathway;negative regulation of vascular smooth muscle cell proliferation;neutrophil degranulation;nitric oxide storage;oligodendrocyte development;positive regulation of superoxide anion generation;regulation of ERK1 and ERK2 cascade;regulation of stress-activated MAPK cascade;response to amino acid;response to estradiol;response to ethanol;response to L-ascorbic acid;response to reactive oxygen species;xenobiotic metabolic process","dinitrosyl-iron complex binding;drug binding;glutathione binding;glutathione peroxidase activity;glutathione transferase activity;JUN kinase binding;kinase regulator activity;nitric oxide binding;S-nitrosoglutathione binding","cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;intracellular;mitochondrion;nucleus;plasma membrane;secretory granule lumen;TRAF2-GSTP1 complex;vesicle","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Fluid shear stress and atherosclerosis;Glutathione metabolism;Hepatocellular carcinoma;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pathways in cancer;Platinum drug resistance;Prostate cancer",null,null,14,14,14,"66.7","66.7","66.7","23.356",0,"323.31",8065600000,144,"0.132204","0.897377","-0.171468","-0.384632","sp|P09211|GSTP1_HUMAN;tr|A8MX94|A8MX94_HUMAN;tr|A0A087X2E9|A0A087X2E9_HUMAN;tr|A0A087X243|A0A087X243_HUMAN","sp|P09211|GSTP1_HUMAN;tr|A8MX94|A8MX94_HUMAN",579,"P09211","GSTP1_HUMAN","Glutathione S-transferase P",null,"GSTP1"]
["25.4898","25.1844","25.6197","25.3975",{"$nulls":3},"activation of signaling protein activity involved in unfolded protein response;ATF6-mediated unfolded protein response;cellular response to antibiotic;cellular response to calcium ion;cellular response to cAMP;cellular response to drug;cellular response to gamma radiation;cellular response to glucose starvation;cellular response to interleukin-4;cellular response to manganese ion;cellular response to nerve growth factor stimulus;cerebellar Purkinje cell layer development;cerebellum structural organization;endoplasmic reticulum unfolded protein response;ER overload response;IRE1-mediated unfolded protein response;maintenance of protein localization in endoplasmic reticulum;negative regulation of apoptotic process;negative regulation of protein homodimerization activity;negative regulation of transforming growth factor beta receptor signaling pathway;neuron apoptotic process;neuron differentiation;PERK-mediated unfolded protein response;positive regulation of cell migration;positive regulation of neuron projection development;positive regulation of protein ubiquitination;positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;protein folding in endoplasmic reticulum;regulation of ATF6-mediated unfolded protein response;regulation of IRE1-mediated unfolded protein response;regulation of PERK-mediated unfolded protein response;regulation of protein folding in endoplasmic reticulum;response to cocaine;response to methamphetamine hydrochloride;stress response to metal ion;substantia nigra development;toxin transport;ubiquitin-dependent ERAD pathway","ATP binding;ATPase activity;cadherin binding;calcium ion binding;chaperone binding;enzyme binding;misfolded protein binding;protein domain specific binding;ribosome binding;ubiquitin protein ligase binding;unfolded protein binding","cell surface;endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular matrix;focal adhesion;integral component of endoplasmic reticulum membrane;melanosome;membrane;midbody;mitochondrion;myelin sheath;nucleus;plasma membrane;protein complex;smooth endoplasmic reticulum","Antigen processing and presentation;Prion diseases;Protein export;Protein processing in endoplasmic reticulum;Thyroid hormone synthesis",null,null,28,28,27,"45.7","45.7","45.7","72.332",0,"287.47",12468000000,257,"0.337695","0.698229","-0.171533","-0.908476","sp|P11021|GRP78_HUMAN","sp|P11021|GRP78_HUMAN",614,"P11021","GRP78_HUMAN","78 kDa glucose-regulated protein {ECO:0000303|PubMed:2840249}","RP-78 {ECO:0000303|PubMed:2840249}","HSPA5"]
["22.4469","22.3311","22.9827","22.1386",{"$nulls":4},"acid phosphatase activity;non-membrane spanning protein tyrosine phosphatase activity","cytoplasm;cytoplasmic side of plasma membrane;cytosol;extracellular exosome;sarcolemma","Adherens junction;Metabolic pathways;Riboflavin metabolism;Thiamine metabolism",null,null,4,4,4,"31.6","31.6","31.6","18.042",0,"23.363",519360000,28,"0.139059","0.888857","-0.171646","-0.402902","sp|P24666|PPAC_HUMAN;tr|G5E9R5|G5E9R5_HUMAN;tr|F2Z2Q9|F2Z2Q9_HUMAN;tr|D3YTI2|D3YTI2_HUMAN","sp|P24666|PPAC_HUMAN;tr|G5E9R5|G5E9R5_HUMAN;tr|F2Z2Q9|F2Z2Q9_HUMAN",790,"P24666","PPAC_HUMAN","Low molecular weight phosphotyrosine protein phosphatase","MW-PTP;MW-PTPase","ACP1"]
["19.7052","18.767","19.4312","19.3849",{"$nulls":3},"carnitine metabolic process, CoA-linked;fatty acid beta-oxidation using acyl-CoA oxidase","carnitine O-acetyltransferase activity;receptor binding","endoplasmic reticulum;mitochondrial inner membrane;mitochondrion;peroxisomal matrix;peroxisome",{"$nulls":3},5,5,5,"10.2","10.2","10.2","70.857",0,"7.8885",137870000,13,"0.125332","0.899716","-0.171994","-0.366207","sp|P43155|CACP_HUMAN;tr|B7ZBP5|B7ZBP5_HUMAN;tr|A6PVN3|A6PVN3_HUMAN","sp|P43155|CACP_HUMAN",1004,"P43155","CACP_HUMAN","Carnitine O-acetyltransferase","arnitine acetylase","CRAT"]
["21.7024","21.6622","22.0049","21.7049",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;oxidative phosphorylation;protein processing involved in protein targeting to mitochondrion","metalloendopeptidase activity;protein complex binding;zinc ion binding","extracellular exosome;mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrial respiratory chain complex IV;mitochondrion;myelin sheath;nucleoplasm","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,7,7,7,26,26,26,"48.442",0,"38.749",562010000,49,"0.429319","0.583625","-0.172667","-1.14088","sp|P22695|QCR2_HUMAN;tr|H3BRG4|H3BRG4_HUMAN;tr|H3BSJ9|H3BSJ9_HUMAN;tr|H3BP04|H3BP04_HUMAN;tr|H3BUE4|H3BUE4_HUMAN;tr|H3BUI9|H3BUI9_HUMAN;tr|A0A087WVZ4|A0A087WVZ4_HUMAN","sp|P22695|QCR2_HUMAN;tr|H3BRG4|H3BRG4_HUMAN;tr|H3BSJ9|H3BSJ9_HUMAN;tr|H3BP04|H3BP04_HUMAN",770,"P22695","QCR2_HUMAN","Cytochrome b-c1 complex subunit 2, mitochondrial",null,"UQCRC2"]
["19.6236","18.2165","20.0921","18.0943",{"$nulls":3},"cristae formation",null,"MICOS complex;mitochondrion",{"$nulls":3},4,4,4,"20.1","20.1","20.1","29.205",0,"6.6677",83008000,8,"0.0456231","0.955409","-0.173167","-0.141734","tr|A0A087WYF7|A0A087WYF7_HUMAN;sp|Q6UXV4|MIC27_HUMAN;tr|A0A087WUX8|A0A087WUX8_HUMAN","tr|A0A087WYF7|A0A087WYF7_HUMAN;sp|Q6UXV4|MIC27_HUMAN;tr|A0A087WUX8|A0A087WUX8_HUMAN",1906,"A0A087WYF7","A0A087WYF7_HUMAN","MICOS complex subunit {ECO:0000256|RuleBase:RU363021}",null,"APOOL"]
["18.429","18.3513","18.6113","18.5186",{"$nulls":3},"aging;aorta morphogenesis;cardiac myofibril assembly;cell chemotaxis;cell migration;cell migration involved in coronary angiogenesis;cell migration involved in vasculogenesis;glycosaminoglycan biosynthetic process;inner ear development;lung growth;male gonad development;MAPK cascade;metanephric comma-shaped body morphogenesis;metanephric glomerular capillary formation;metanephric glomerular mesangial cell proliferation involved in metanephros development;metanephric mesenchymal cell migration;metanephric mesenchyme development;metanephric S-shaped body morphogenesis;negative regulation of apoptotic process;negative regulation of platelet-derived growth factor receptor-beta signaling pathway;peptidyl-tyrosine phosphorylation;phosphatidylinositol metabolic process;phosphatidylinositol-mediated signaling;platelet-derived growth factor receptor signaling pathway;platelet-derived growth factor receptor-beta signaling pathway;positive regulation of apoptotic process;positive regulation of calcium ion import;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway;positive regulation of chemotaxis;positive regulation of collagen biosynthetic process;positive regulation of DNA biosynthetic process;positive regulation of ERK1 and ERK2 cascade;positive regulation of fibroblast proliferation;positive regulation of hepatic stellate cell activation;positive regulation of MAP kinase activity;positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;positive regulation of mitotic nuclear division;positive regulation of phosphatidylinositol 3-kinase activity;positive regulation of phosphatidylinositol 3-kinase signaling;positive regulation of phospholipase C activity;positive regulation of phosphoprotein phosphatase activity;positive regulation of protein kinase B signaling;positive regulation of reactive oxygen species metabolic process;positive regulation of Rho protein signal transduction;positive regulation of smooth muscle cell migration;positive regulation of smooth muscle cell proliferation;protein autophosphorylation;regulation of actin cytoskeleton organization;response to estradiol;response to estrogen;response to fluid shear stress;response to hydrogen peroxide;response to hyperoxia;response to retinoic acid;response to toxic substance;retina vasculature development in camera-type eye;signal transduction;smooth muscle cell chemotaxis;wound healing","ATP binding;enzyme binding;phosphatidylinositol 3-kinase binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;platelet activating factor receptor activity;platelet-derived growth factor beta-receptor activity;platelet-derived growth factor binding;platelet-derived growth factor receptor binding;platelet-derived growth factor-activated receptor activity;protein kinase binding;protein tyrosine kinase activity;Ras guanyl-nucleotide exchange factor activity;receptor binding;vascular endothelial growth factor binding","apical plasma membrane;cell surface;cytoplasm;cytoplasmic vesicle;extracellular exosome;focal adhesion;integral component of membrane;intrinsic component of plasma membrane;lysosomal lumen;membrane;nucleus;plasma membrane","Calcium signaling pathway;Central carbon metabolism in cancer;Choline metabolism in cancer;EGFR tyrosine kinase inhibitor resistance;Focal adhesion;Gap junction;Glioma;Human papillomavirus infection;Jak-STAT signaling pathway;MAPK signaling pathway;Melanoma;MicroRNAs in cancer;Pathways in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prostate cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton",null,null,1,1,1,"0.6","0.6","0.6","123.97","0.0075459","1.7406",104630000,8,"0.992323","0.299716","-0.174787","-2.88991","sp|P09619|PGFRB_HUMAN","sp|P09619|PGFRB_HUMAN",589,"P09619","PGFRB_HUMAN","Platelet-derived growth factor receptor beta","DGFR-beta;DGF-R-beta","PDGFRB"]
["22.4706","22.3645","22.7097","22.4774",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;interleukin-12-mediated signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of endopeptidase activity;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of G1/S transition of mitotic cell cycle;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of proteasomal protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activator activity;identical protein binding","cytoplasm;cytosol;extracellular exosome;membrane;nucleoplasm;proteasome activator complex;proteasome complex","Antigen processing and presentation;Proteasome",null,null,10,10,10,"54.4","54.4","54.4","27.401",0,"221.08",806020000,50,"0.519964","0.505309","-0.175979","-1.37839","sp|Q9UL46|PSME2_HUMAN;tr|A0A087X1Z3|A0A087X1Z3_HUMAN;tr|H0YM70|H0YM70_HUMAN;tr|H0YKU2|H0YKU2_HUMAN","sp|Q9UL46|PSME2_HUMAN;tr|A0A087X1Z3|A0A087X1Z3_HUMAN;tr|H0YM70|H0YM70_HUMAN",2885,"Q9UL46","PSME2_HUMAN","Proteasome activator complex subunit 2",null,"PSME2"]
["23.5559","23.1053","23.6858","23.3288",{"$nulls":3},"ATP biosynthetic process;cristae formation;embryo development;lipid metabolic process;mitochondrial ATP synthesis coupled proton transport;negative regulation of endothelial cell proliferation;positive regulation of blood vessel endothelial cell migration","angiostatin binding;ATP binding;MHC class I protein binding;proton-transporting ATP synthase activity, rotational mechanism;RNA binding;transmembrane transporter activity","extracellular exosome;extracellular matrix;membrane;mitochondrial inner membrane;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex;mitochondrion;myelin sheath;plasma membrane;proton-transporting ATP synthase complex;proton-transporting ATP synthase complex, catalytic core F(1)","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,21,21,21,"44.7","44.7","44.7","59.75",0,"323.31",3150800000,138,"0.220883","0.802318","-0.176699","-0.614762","sp|P25705|ATPA_HUMAN;tr|K7EK77|K7EK77_HUMAN;tr|K7ERX7|K7ERX7_HUMAN;tr|K7EJP1|K7EJP1_HUMAN;tr|K7ENJ4|K7ENJ4_HUMAN;tr|K7EQH4|K7EQH4_HUMAN;tr|K7ESA0|K7ESA0_HUMAN","sp|P25705|ATPA_HUMAN;tr|K7EK77|K7EK77_HUMAN;tr|K7ERX7|K7ERX7_HUMAN",800,"P25705","ATPA_HUMAN","ATP synthase subunit alpha, mitochondrial",null,"ATP5A1"]
["27.2943","27.0146","27.5321","27.1322",{"$nulls":4},"GTP binding;GTPase activity;translation elongation factor activity","cytoplasm;extracellular exosome;extracellular space;nucleus",{"$nulls":3},20,20,12,"43.5","43.5","27.1","50.184",0,"323.31",40835000000,374,"0.265892","0.756134","-0.177713","-0.728348","sp|Q5VTE0|EF1A3_HUMAN;sp|P68104|EF1A1_HUMAN;tr|A0A087WVQ9|A0A087WVQ9_HUMAN;tr|A0A087WV01|A0A087WV01_HUMAN;tr|A6PW80|A6PW80_HUMAN;tr|Q5JR01|Q5JR01_HUMAN","sp|Q5VTE0|EF1A3_HUMAN;sp|P68104|EF1A1_HUMAN;tr|A0A087WVQ9|A0A087WVQ9_HUMAN;tr|A0A087WV01|A0A087WV01_HUMAN",1357,"Q5VTE0","EF1A3_HUMAN","Putative elongation factor 1-alpha-like 3","F-1-alpha-like 3","EEF1A1P5"]
["20.2312","21.7743","20.9733","21.389",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cilium assembly;ER to Golgi vesicle-mediated transport;intraciliary transport involved in cilium assembly;macroautophagy;positive regulation of ATP-dependent microtubule motor activity, plus-end-directed;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;sister chromatid cohesion;transport along microtubule","cytoskeletal protein binding;dynein intermediate chain binding;dynein light intermediate chain binding;motor activity;protein heterodimerization activity;protein homodimerization activity;scaffold protein binding","centrosome;ciliary tip;cilium;cytoplasmic dynein complex;cytosol;membrane;microtubule;mitochondrion;myosin complex;myosin V complex;nucleus;plasma membrane","Vasopressin-regulated water reabsorption",null,null,1,1,1,"12.4","12.4","12.4","10.35",0,"5.8055",130200000,4,"0.0736326","0.930341","-0.178412","-0.223281","sp|Q96FJ2|DYL2_HUMAN;sp|P63167|DYL1_HUMAN","sp|Q96FJ2|DYL2_HUMAN;sp|P63167|DYL1_HUMAN",1344,"Q96FJ2","DYL2_HUMAN","Dynein light chain 2, cytoplasmic",null,"DYNLL2"]
["21.1541","20.8749","21.707","20.6796",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent protein catabolic process;Wnt signaling pathway, planar cell polarity pathway","enzyme regulator activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, lid subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,12,12,12,"31.1","31.1","31.1","60.977",0,"53.242",878870000,66,"0.114154","0.904681","-0.178862","-0.335984","sp|O43242|PSMD3_HUMAN;tr|F5H8K4|F5H8K4_HUMAN","sp|O43242|PSMD3_HUMAN",235,"O43242","PSMD3_HUMAN","26S proteasome non-ATPase regulatory subunit 3",null,"PSMD3"]
["15.6125","15.6576","15.9646","15.6643",{"$nulls":3},"endomembrane system organization;endosome organization;exocytosis;Golgi to plasma membrane transport;intracellular signal transduction;positive regulation of tumor necrosis factor production;protein transport;receptor recycling;regulation of ARF protein signal transduction","ARF guanyl-nucleotide exchange factor activity;GABA receptor binding;guanyl-nucleotide exchange factor activity;myosin binding;protein kinase A regulatory subunit binding","asymmetric synapse;axonemal microtubule;cell junction;cytoplasmic vesicle;cytosol;dendritic spine;Golgi membrane;membrane;microtubule organizing center;perinuclear region of cytoplasm;recycling endosome;symmetric synapse;trans-Golgi network","Endocytosis",null,null,3,3,3,"2.4","2.4","2.4","202.04",0,"5.6935",45640000,7,"0.445133","0.557256","-0.179406","-1.18165","sp|Q9Y6D5|BIG2_HUMAN","sp|Q9Y6D5|BIG2_HUMAN",3045,"Q9Y6D5","BIG2_HUMAN","Brefeldin A-inhibited guanine nucleotide-exchange protein 2","refeldin A-inhibited GEP 2","ARFGEF2"]
["18.9473","18.517","19.144","18.6805",{"$nulls":5},"centrosome;microtubule;mitochondrion;spindle pole",{"$nulls":3},3,3,3,"14.6","14.6","14.6","35.808",0,"19.487",91787000,13,"0.20311","0.819093","-0.180069","-0.569497","sp|Q96DB5|RMD1_HUMAN;tr|E5RGC8|E5RGC8_HUMAN;tr|H0YC27|H0YC27_HUMAN;tr|H0YC67|H0YC67_HUMAN;tr|H0YBD9|H0YBD9_HUMAN;tr|H0YB03|H0YB03_HUMAN;tr|H0YB83|H0YB83_HUMAN;tr|E5RH53|E5RH53_HUMAN","sp|Q96DB5|RMD1_HUMAN",2256,"Q96DB5","RMD1_HUMAN","Regulator of microtubule dynamics protein 1","MD-1;RMD-1","RMDN1"]
["16.9712","16.8658","17.3254","16.872",{"$nulls":3},"histone monoubiquitination","ubiquitin-protein transferase activity","nucleoplasm",{"$nulls":3},4,4,4,"8.2","8.2","8.2","109.05",0,"4.0902",85827000,9,"0.284109","0.745608","-0.180161","-0.774072","tr|H3BP71|H3BP71_HUMAN;sp|O75150|BRE1B_HUMAN","tr|H3BP71|H3BP71_HUMAN;sp|O75150|BRE1B_HUMAN",323,"H3BP71","H3BP71_HUMAN",null,null,"RNF40"]
["17.8784","17.7195","18.1158","17.8429",{"$nulls":4},"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor",{"$nulls":4},1,1,1,"4.9","4.9","4.9","33.167","0.0047233","1.9425",23948000,4,"0.429947","0.582104","-0.180399","-1.1425","tr|A0A096LPD9|A0A096LPD9_HUMAN;tr|E7EWK1|E7EWK1_HUMAN;tr|E7ENA2|E7ENA2_HUMAN;tr|D3YTF8|D3YTF8_HUMAN;tr|D3YTF9|D3YTF9_HUMAN;sp|Q9NNW7|TRXR2_HUMAN","tr|A0A096LPD9|A0A096LPD9_HUMAN;tr|E7EWK1|E7EWK1_HUMAN;tr|E7ENA2|E7ENA2_HUMAN;tr|D3YTF8|D3YTF8_HUMAN;tr|D3YTF9|D3YTF9_HUMAN;sp|Q9NNW7|TRXR2_HUMAN",2653,"A0A096LPD9","A0A096LPD9_HUMAN",null,null,"TXNRD2"]
["22.1435","21.9422","22.1696","22.2775",{"$nulls":3},"nucleosome assembly",null,"nucleus",{"$nulls":3},7,5,5,42,"36.7","36.7","24.366",0,"111.64",664660000,36,"0.594233","0.443392","-0.180671","-1.58161","tr|F8W020|F8W020_HUMAN;tr|F8VXI6|F8VXI6_HUMAN;tr|F8VUX1|F8VUX1_HUMAN;tr|F8VY35|F8VY35_HUMAN;tr|F8W0J6|F8W0J6_HUMAN;tr|F5H4R6|F5H4R6_HUMAN;tr|H0YIV4|H0YIV4_HUMAN;sp|P55209|NP1L1_HUMAN;tr|H0YHC3|H0YHC3_HUMAN;tr|F8W118|F8W118_HUMAN;tr|F8VV59|F8VV59_HUMAN;tr|B7Z9C2|B7Z9C2_HUMAN;tr|H0YH88|H0YH88_HUMAN;tr|F8W543|F8W543_HUMAN;tr|F8VRJ2|F8VRJ2_HUMAN;tr|F8VVB5|F8VVB5_HUMAN","tr|F8W020|F8W020_HUMAN;tr|F8VXI6|F8VXI6_HUMAN;tr|F8VUX1|F8VUX1_HUMAN;tr|F8VY35|F8VY35_HUMAN;tr|F8W0J6|F8W0J6_HUMAN;tr|F5H4R6|F5H4R6_HUMAN;tr|H0YIV4|H0YIV4_HUMAN;sp|P55209|NP1L1_HUMAN;tr|H0YHC3|H0YHC3_HUMAN;tr|F8W118|F8W118_HUMAN;tr|F8VV59|F8VV59_HUMAN;tr|B7Z9C2|B7Z9C2_HUMAN;tr|H0YH88|H0YH88_HUMAN;tr|F8W543|F8W543_HUMAN;tr|F8VRJ2|F8VRJ2_HUMAN;tr|F8VVB5|F8VVB5_HUMAN",1208,"F8W020","F8W020_HUMAN",null,null,"NAP1L1"]
["17.6902","17.024","16.8216","18.2542",{"$nulls":3},"regulation of actin polymerization or depolymerization;regulation of axonogenesis;regulation of lamellipodium assembly","actin binding;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity","cytoplasm;cytoskeleton;nucleus","Axon guidance;Regulation of actin cytoskeleton",null,null,3,3,3,"5.9","5.9","5.9","72.995",0,"5.3768",53310000,3,"0.0756256","0.930417","-0.180864","-0.228957","sp|Q8TE77|SSH3_HUMAN;tr|E9PIT5|E9PIT5_HUMAN;tr|A0A087WWG1|A0A087WWG1_HUMAN;tr|C9JUG3|C9JUG3_HUMAN","sp|Q8TE77|SSH3_HUMAN",2124,"Q8TE77","SSH3_HUMAN","Protein phosphatase Slingshot homolog 3",null,"SSH3"]
["19.3241","19.3467","19.779","19.2546",{"$nulls":9},2,2,2,"30.8","30.8","30.8","9.7504","0.00038986","3.1391",20927000,5,"0.25114","0.771744","-0.181411","-0.691244","tr|H7C284|H7C284_HUMAN;sp|Q6ZSS7|MFSD6_HUMAN","tr|H7C284|H7C284_HUMAN;sp|Q6ZSS7|MFSD6_HUMAN",1917,"H7C284","H7C284_HUMAN",null,null,"MFSD6"]
["19.3271","19.3786","20.1298","18.939",{"$nulls":4},"RNA binding",{"$nulls":4},8,8,8,"27.1","27.1","27.1","54.626",0,"29.182",207730000,27,"0.102696","0.913446","-0.181555","-0.304648","tr|A0A0J9YYL3|A0A0J9YYL3_HUMAN;tr|A0A0J9YXJ8|A0A0J9YXJ8_HUMAN;tr|A0A0J9YVP6|A0A0J9YVP6_HUMAN;tr|A0A0J9YXX5|A0A0J9YXX5_HUMAN;sp|Q9UHX1|PUF60_HUMAN;tr|A0A0J9YVR6|A0A0J9YVR6_HUMAN;tr|E9PQ56|E9PQ56_HUMAN;tr|A0A0J9YWM1|A0A0J9YWM1_HUMAN;tr|H0YEM1|H0YEM1_HUMAN;tr|E9PMU7|E9PMU7_HUMAN;tr|E9PN18|E9PN18_HUMAN;tr|E9PL19|E9PL19_HUMAN;tr|H0YCP8|H0YCP8_HUMAN","tr|A0A0J9YYL3|A0A0J9YYL3_HUMAN;tr|A0A0J9YXJ8|A0A0J9YXJ8_HUMAN;tr|A0A0J9YVP6|A0A0J9YVP6_HUMAN;tr|A0A0J9YXX5|A0A0J9YXX5_HUMAN;sp|Q9UHX1|PUF60_HUMAN;tr|A0A0J9YVR6|A0A0J9YVR6_HUMAN;tr|E9PQ56|E9PQ56_HUMAN;tr|A0A0J9YWM1|A0A0J9YWM1_HUMAN;tr|H0YEM1|H0YEM1_HUMAN;tr|E9PMU7|E9PMU7_HUMAN;tr|E9PN18|E9PN18_HUMAN",2841,"A0A0J9YYL3","A0A0J9YYL3_HUMAN",null,null,"PUF60"]
["19.6309","19.5241","19.9818","19.5374",{"$nulls":5},"cytosol",{"$nulls":3},3,3,3,"16.2","16.2","16.2","26.795",0,"4.0012",96368000,15,"0.293195","0.738264","-0.1821","-0.796855","tr|H7C488|H7C488_HUMAN;sp|Q9NQ48|LZTL1_HUMAN","tr|H7C488|H7C488_HUMAN;sp|Q9NQ48|LZTL1_HUMAN",2665,"H7C488","H7C488_HUMAN",null,null,"LZTFL1"]
["23.0915","22.9643","23.2413","23.1791",{"$nulls":3},"cell redox homeostasis;chaperone-mediated protein folding;protein folding;protein secretion;response to endoplasmic reticulum stress","peptide disulfide oxidoreductase activity;protein disulfide isomerase activity;RNA binding","cell surface;endoplasmic reticulum;endoplasmic reticulum lumen;extracellular space;melanosome","Protein processing in endoplasmic reticulum;Thyroid hormone synthesis;Vibrio cholerae infection",null,null,24,24,24,"45.6","45.6","45.6","72.932",0,"259.77",3486100000,168,"0.907864","0.29495","-0.182252","-2.5732","sp|P13667|PDIA4_HUMAN;tr|C9JMN9|C9JMN9_HUMAN","sp|P13667|PDIA4_HUMAN",659,"P13667","PDIA4_HUMAN","Protein disulfide-isomerase A4",null,"PDIA4"]
["17.1754","16.8422","18.2484","16.1338",{"$nulls":3},"signal transduction","protein phosphatase regulator activity","protein phosphatase type 2A complex",{"$nulls":3},3,3,3,"10.1","10.1","10.1","59.335",0,"3.9358",57439000,5,"0.0553126","0.945815","-0.182322","-0.170341","tr|H0Y8C4|H0Y8C4_HUMAN;tr|E9PFR3|E9PFR3_HUMAN;sp|Q14738|2A5D_HUMAN;tr|H0YJ35|H0YJ35_HUMAN;tr|Q96B13|Q96B13_HUMAN;sp|Q13362|2A5G_HUMAN;tr|H0YJ75|H0YJ75_HUMAN","tr|H0Y8C4|H0Y8C4_HUMAN;tr|E9PFR3|E9PFR3_HUMAN;sp|Q14738|2A5D_HUMAN",1642,"H0Y8C4","H0Y8C4_HUMAN",null,null,"PPP2R5D"]
["22.955","22.8333","22.8481","23.3051",{"$nulls":3},"cellular response to organonitrogen compound;mesenchyme migration;muscle contraction;muscle filament sliding;positive regulation of gene expression;response to extracellular stimulus;response to lithium ion;response to mechanical stimulus;response to steroid hormone;skeletal muscle fiber adaptation;skeletal muscle fiber development;skeletal muscle thin filament assembly","ADP binding;ATP binding;myosin binding;structural constituent of cytoskeleton","actin cytoskeleton;actin filament;blood microparticle;cell body;cytosol;extracellular exosome;extracellular space;filopodium;lamellipodium;sarcomere;stress fiber;striated muscle thin filament",{"$nulls":3},14,1,1,"33.2","4.2","4.2","42.051",0,"125.07",2165100000,80,"0.283152","0.745719","-0.182461","-0.771673","sp|P68133|ACTS_HUMAN;sp|P68032|ACTC_HUMAN;sp|P63267|ACTH_HUMAN;sp|P62736|ACTA_HUMAN;tr|A6NL76|A6NL76_HUMAN;tr|F8WB63|F8WB63_HUMAN;tr|B8ZZJ2|B8ZZJ2_HUMAN;tr|C9JFL5|C9JFL5_HUMAN;tr|F6UVQ4|F6UVQ4_HUMAN;tr|F6QUT6|F6QUT6_HUMAN","sp|P68133|ACTS_HUMAN;sp|P68032|ACTC_HUMAN;sp|P63267|ACTH_HUMAN;sp|P62736|ACTA_HUMAN;tr|A6NL76|A6NL76_HUMAN;tr|F8WB63|F8WB63_HUMAN;tr|B8ZZJ2|B8ZZJ2_HUMAN;tr|C9JFL5|C9JFL5_HUMAN;tr|F6UVQ4|F6UVQ4_HUMAN;tr|F6QUT6|F6QUT6_HUMAN",1355,"P68133","ACTS_HUMAN","Actin, alpha skeletal muscle",null,"ACTA1"]
["24.3154","24.1644","24.6557","24.1897",{"$nulls":3},"maturation of LSU-rRNA;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;membrane;nucleolus;nucleus;polysomal ribosome","Ribosome",null,null,11,11,11,38,38,38,"29.995",0,"52.837",2168200000,62,"0.273067","0.755517","-0.182796","-0.746367","sp|P62424|RL7A_HUMAN;tr|Q5T8U3|Q5T8U3_HUMAN;tr|Q5T8U2|Q5T8U2_HUMAN","sp|P62424|RL7A_HUMAN;tr|Q5T8U3|Q5T8U3_HUMAN;tr|Q5T8U2|Q5T8U2_HUMAN",1307,"P62424","RL7A_HUMAN","60S ribosomal protein L7a",null,"RPL7A"]
["23.4675","23.5059","23.7151","23.6239",{"$nulls":3},"response to stress","chaperone binding;Hsp70 protein binding;protein C-terminus binding;RNA binding","cytosol;Golgi apparatus;myelin sheath;nucleus;protein complex","Prion diseases",null,null,19,19,19,"38.3","38.3","38.3","62.639",0,"299.86",4487200000,139,"1.17956","0.319023","-0.182802","-3.69287","sp|P31948|STIP1_HUMAN;tr|F5H783|F5H783_HUMAN;tr|F5GXD8|F5GXD8_HUMAN;tr|H0YGI8|H0YGI8_HUMAN","sp|P31948|STIP1_HUMAN;tr|F5H783|F5H783_HUMAN",898,"P31948","STIP1_HUMAN","Stress-induced-phosphoprotein 1","TI1","STIP1"]
["17.944","18.2391","18.3795","18.1701",{"$nulls":3},"cell division;Golgi disassembly;histone H3-S10 phosphorylation;histone H3-T3 phosphorylation;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;protein autophosphorylation;protein phosphorylation;regulation of cell shape","ATP binding;histone kinase activity (H3-S10 specific);histone kinase activity (H3-T3 specific);nucleosomal histone binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity","cytosol;Golgi stack;nucleolus;nucleoplasm;nucleus;spindle",{"$nulls":3},3,3,3,"14.1","14.1","14.1","45.476",0,"9.2858",44817000,10,"0.379118","0.643337","-0.183279","-1.0129","sp|Q99986|VRK1_HUMAN;tr|H0YJF7|H0YJF7_HUMAN;tr|H0YJ50|H0YJ50_HUMAN","sp|Q99986|VRK1_HUMAN",2403,"Q99986","VRK1_HUMAN","Serine/threonine-protein kinase VRK1",null,"VRK1"]
["14.4226","14.6423","14.9787","14.4537",{"$nulls":3},"cellular protein metabolic process;cholesterol metabolic process;lipid transport;negative regulation of amyloid-beta formation;negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;negative regulation of MAP kinase activity;negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;negative regulation of neurofibrillary tangle assembly;negative regulation of neurogenesis;negative regulation of neuron death;negative regulation of protein binding;negative regulation of protein oligomerization;negative regulation of tau-protein kinase activity;positive regulation of choline O-acetyltransferase activity;positive regulation of early endosome to recycling endosome transport;positive regulation of endocytic recycling;positive regulation of ER to Golgi vesicle-mediated transport;positive regulation of protein catabolic process;positive regulation of protein exit from endoplasmic reticulum;positive regulation of protein localization to early endosome;post-Golgi vesicle-mediated transport;protein maturation;protein retention in Golgi apparatus;protein targeting;protein targeting to Golgi;protein targeting to lysosome;receptor-mediated endocytosis;regulation of smooth muscle cell migration","ADP-ribosylation factor binding;amyloid-beta binding;low-density lipoprotein particle binding;low-density lipoprotein receptor activity;transmembrane signaling receptor activity","early endosome;endoplasmic reticulum;endosome;endosome membrane;extracellular exosome;extracellular space;Golgi apparatus;Golgi cisterna;Golgi membrane;integral component of plasma membrane;low-density lipoprotein particle;membrane;nuclear envelope lumen;recycling endosome;trans-Golgi network",{"$nulls":3},2,2,2,"1.4","1.4","1.4","248.42",0,"9.672",27540000,8,"0.233038","0.791981","-0.183721","-0.645561","sp|Q92673|SORL_HUMAN;tr|E9PKB0|E9PKB0_HUMAN;tr|E9PS32|E9PS32_HUMAN;tr|E9PP43|E9PP43_HUMAN;tr|E9PPB3|E9PPB3_HUMAN","sp|Q92673|SORL_HUMAN;tr|E9PKB0|E9PKB0_HUMAN;tr|E9PS32|E9PS32_HUMAN;tr|E9PP43|E9PP43_HUMAN;tr|E9PPB3|E9PPB3_HUMAN",2185,"Q92673","SORL_HUMAN","Sortilin-related receptor",null,"SORL1"]
["15.6016","15.0335","16.0706","14.933",{"$nulls":3},"brain development;homophilic cell adhesion via plasma membrane adhesion molecules;negative regulation of cell adhesion;neural tube closure;neuroblast proliferation;positive regulation of axonogenesis;positive regulation of neuron projection development;regulation of cell shape;regulation of GTPase activity;regulation of neuron migration;regulation of protein phosphorylation;semaphorin-plexin signaling pathway","semaphorin receptor activity","cell surface;extracellular exosome;integral component of plasma membrane","Axon guidance",null,null,2,2,2,"1.9","1.9","1.9","205.12",0,"7.1652",42709000,11,"0.0973004","0.917104","-0.184232","-0.289756","sp|O15031|PLXB2_HUMAN;tr|A6QRG9|A6QRG9_HUMAN","sp|O15031|PLXB2_HUMAN;tr|A6QRG9|A6QRG9_HUMAN",193,"O15031","PLXB2_HUMAN","Plexin-B2",null,"PLXNB2"]
["15.5538","15.2686","15.6136","15.578",{"$nulls":3},"metabolic process","hydrolase activity","cytosol",{"$nulls":3},1,1,1,"3.3","3.3","3.3","58.855","0.0011082","2.7137",5785600,4,"0.484552","0.5225","-0.184591","-1.28442","tr|E5RFU2|E5RFU2_HUMAN;sp|P34913|HYES_HUMAN","tr|E5RFU2|E5RFU2_HUMAN;sp|P34913|HYES_HUMAN",917,"E5RFU2","E5RFU2_HUMAN",null,null,"EPHX2"]
["19.1551","18.5148","19.5358","18.5035",{"$nulls":4},"oxidoreductase activity",{"$nulls":4},2,2,2,"9.9","9.9","9.9","23.803",0,"3.96",59976000,5,"0.102491","0.913116","-0.184692","-0.304083","tr|J3KS22|J3KS22_HUMAN;tr|J3QS36|J3QS36_HUMAN;sp|Q7Z4W1|DCXR_HUMAN","tr|J3KS22|J3KS22_HUMAN;tr|J3QS36|J3QS36_HUMAN;sp|Q7Z4W1|DCXR_HUMAN",1958,"J3KS22","J3KS22_HUMAN",null,null,"DCXR"]
["18.9572","18.6061","19.0501","18.8835",{"$nulls":3},"regulation of cell motility;regulation of microtubule-based process",null,"cytosol;nucleus",{"$nulls":3},3,3,3,"20.5","20.5","20.5","33.733",0,"28.819",80490000,11,"0.355201","0.679816","-0.185078","-0.952513","sp|Q9Y316|MEMO1_HUMAN;tr|B5MCI6|B5MCI6_HUMAN","sp|Q9Y316|MEMO1_HUMAN",2970,"Q9Y316","MEMO1_HUMAN","Protein MEMO1",null,"MEMO1"]
["19.4574","20.1706","20.4077","19.5908",{"$nulls":3},"succinate metabolic process;succinyl-CoA metabolic process;succinyl-CoA pathway;tricarboxylic acid cycle","ATP binding;metal ion binding;succinate-CoA ligase (ADP-forming) activity","extracellular exosome;mitochondrial matrix;mitochondrion;myelin sheath","Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways;Propanoate metabolism",null,null,3,3,3,"6.3","6.3","6.3","50.317",0,"8.7491",269480000,18,"0.116222","0.904068","-0.185217","-0.3416","sp|Q9P2R7|SUCB1_HUMAN;tr|Q5T9Q8|Q5T9Q8_HUMAN;tr|Q5T9Q5|Q5T9Q5_HUMAN","sp|Q9P2R7|SUCB1_HUMAN;tr|Q5T9Q8|Q5T9Q8_HUMAN;tr|Q5T9Q5|Q5T9Q5_HUMAN",2793,"Q9P2R7","SUCB1_HUMAN","Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03220}",null,"SUCLA2"]
["17.5947","18.2086","17.994","18.1804",{"$nulls":3},"vesicle docking involved in exocytosis",{"$nulls":5},3,3,3,"7.8","7.8","7.8","50.736",0,"5.5445",63958000,8,"0.206637","0.816187","-0.185568","-0.578505","tr|A0A087WU65|A0A087WU65_HUMAN;sp|Q9NRW7|VPS45_HUMAN;tr|A0A0K0K1C6|A0A0K0K1C6_HUMAN","tr|A0A087WU65|A0A087WU65_HUMAN;sp|Q9NRW7|VPS45_HUMAN",2684,"A0A087WU65","A0A087WU65_HUMAN",null,null,"VPS45"]
["13.4271","13.9633","13.9987","13.7637",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K11-linked ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle",null,"anaphase-promoting complex;cytosol;nucleoplasm","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis",null,null,1,1,1,"0.6","0.6","0.6","216.5","0.0053727","1.9049",11869000,1,"0.229107","0.794056","-0.18605","-0.635612","sp|Q9H1A4|APC1_HUMAN","sp|Q9H1A4|APC1_HUMAN",2567,"Q9H1A4","APC1_HUMAN","Anaphase-promoting complex subunit 1","PC1","ANAPC1"]
["17.0458","16.7716","17.4157","16.7767",{"$nulls":3},"cell adhesion;cell-matrix adhesion;signal transduction","laminin binding;laminin receptor activity;protein C-terminus binding;transmembrane signaling receptor activity","external side of plasma membrane;extracellular exosome;extracellular matrix;extracellular region;integral component of plasma membrane;plasma membrane",{"$nulls":3},4,4,4,"11.9","11.9","11.9","67.404",0,"8.3986",62992000,12,"0.191354","0.830182","-0.18751","-0.539373","sp|P50895|BCAM_HUMAN;tr|A0A087WXM8|A0A087WXM8_HUMAN;tr|K7ENU8|K7ENU8_HUMAN","sp|P50895|BCAM_HUMAN;tr|A0A087WXM8|A0A087WXM8_HUMAN",1121,"P50895","BCAM_HUMAN","Basal cell adhesion molecule",null,"BCAM"]
["16.0833","14.4913","16.9252","14.0255",{"$nulls":3},"mRNA processing;regulation of alternative mRNA splicing, via spliceosome;regulation of apoptotic process;RNA splicing","identical protein binding;metal ion binding;miRNA binding;protein complex binding;RNA binding","nuclear speck;nucleus",{"$nulls":3},2,2,2,"3.1","3.1","3.1","103.53",0,"3.6821",25754000,8,"0.0362795","0.957944","-0.188066","-0.113704","sp|P98175|RBM10_HUMAN;tr|A0A0A0MR66|A0A0A0MR66_HUMAN","sp|P98175|RBM10_HUMAN;tr|A0A0A0MR66|A0A0A0MR66_HUMAN",1396,"P98175","RBM10_HUMAN","RNA-binding protein 10 {ECO:0000305}",null,"RBM10"]
["17.9081","18.1182","18.0072","18.3959",{"$nulls":3},"actin filament organization;cell cycle;cell division;cell-cell adhesion;negative regulation of small GTPase mediated signal transduction;negative regulation of transforming growth factor beta1 production;positive regulation of protein localization to nucleus;proteasome-mediated ubiquitin-dependent protein catabolic process;protein complex assembly;regulation of actin cytoskeleton reorganization;regulation of receptor-mediated endocytosis;signal transduction;substrate-dependent cell migration, cell extension;vesicle organization","beta-catenin binding;cadherin binding;protein complex binding;protein C-terminus binding;SH3 domain binding;structural constituent of cytoskeleton;vascular endothelial growth factor receptor binding","actin cytoskeleton;cell-cell junction;cytoplasm;endocytic vesicle;extracellular exosome;filamentous actin;perinuclear region of cytoplasm;plasma membrane;ruffle","Bacterial invasion of epithelial cells",null,null,4,4,4,8,8,8,"71.45",0,"8.0204",80828000,10,"0.315579","0.713741","-0.188438","-0.852971","sp|Q9Y5K6|CD2AP_HUMAN","sp|Q9Y5K6|CD2AP_HUMAN",3018,"Q9Y5K6","CD2AP_HUMAN","CD2-associated protein",null,"CD2AP"]
["17.5298","17.6305","18.5177","17.0198",{"$nulls":3},"double-strand break repair;meiotic cell cycle","3'-5' exonuclease activity;endonuclease activity;manganese ion binding","Mre11 complex;nucleoplasm",{"$nulls":3},3,3,3,"7.6","7.6","7.6","80.521","0.00039604","3.2995",56433000,11,"0.0835081","0.927018","-0.188613","-0.251259","tr|F8W7U8|F8W7U8_HUMAN;sp|P49959|MRE11_HUMAN;tr|F5GXT0|F5GXT0_HUMAN","tr|F8W7U8|F8W7U8_HUMAN;sp|P49959|MRE11_HUMAN",1106,"F8W7U8","F8W7U8_HUMAN",null,null,"MRE11"]
["16.3164","15.4412","16.3165","15.819",{"$nulls":3},"protein import into nucleus;regulation of gene silencing by miRNA;signal transduction","protein transporter activity;Ran GTPase binding","cytosol;nuclear envelope;nucleoplasm",{"$nulls":3},3,3,3,"3.7","3.7","3.7","119.94",0,"5.9067",61442000,6,"0.128768","0.898775","-0.188969","-0.375434","sp|O15397|IPO8_HUMAN","sp|O15397|IPO8_HUMAN",220,"O15397","IPO8_HUMAN","Importin-8","mp8","IPO8"]
["23.788","23.5122","24.0678","23.6135",{"$nulls":3},"aging;cellular response to hydrogen peroxide;cellular response to metal ion;negative regulation of apoptotic process;negative regulation of catalytic activity;nitric oxide biosynthetic process;positive regulation of neuron apoptotic process;regulation of cellular amino acid metabolic process;response to electrical stimulus;response to estradiol;response to ethanol;response to hydrogen sulfide;response to nitrogen compound;response to nutrient;response to toxic substance;synaptic transmission, cholinergic;xenobiotic metabolic process","cytochrome-b5 reductase activity, acting on NAD(P)H;identical protein binding;NAD(P)H dehydrogenase (quinone) activity;RNA binding;superoxide dismutase activity","cytoplasm;cytosol;dendrite;extracellular exosome;neuronal cell body","Fluid shear stress and atherosclerosis;Hepatocellular carcinoma;Metabolic pathways;Pathways in cancer;Ubiquinone and other terpenoid-quinone biosynthesis",null,null,8,8,8,"34.3","34.3","34.3","30.867",0,"199.68",1746600000,76,"0.261404","0.760184","-0.190538","-0.717068","sp|P15559|NQO1_HUMAN;tr|B4DLR8|B4DLR8_HUMAN;tr|H3BNV2|H3BNV2_HUMAN;tr|H3BRK3|H3BRK3_HUMAN","sp|P15559|NQO1_HUMAN;tr|B4DLR8|B4DLR8_HUMAN;tr|H3BNV2|H3BNV2_HUMAN;tr|H3BRK3|H3BRK3_HUMAN",687,"P15559","NQO1_HUMAN","NAD(P)H dehydrogenase [quinone] 1",null,"NQO1"]
["19.1586","19.0018","19.3644","19.1775",{"$nulls":3},"mRNA splicing, via spliceosome;negative regulation of phosphatase activity;spliceosomal tri-snRNP complex assembly","ribonucleoprotein complex binding","cytoplasm;cytosol;fibrillar center;nuclear speck;nucleoplasm;nucleus;U5 snRNP",{"$nulls":3},4,4,4,"19.9","19.9","19.9","37.646",0,"8.9732",61501000,14,"0.587874","0.450163","-0.19072","-1.56384","sp|O95400|CD2B2_HUMAN","sp|O95400|CD2B2_HUMAN",434,"O95400","CD2B2_HUMAN","CD2 antigen cytoplasmic tail-binding protein 2","D2 cytoplasmic domain-binding protein 2;D2 tail-binding protein 2","CD2BP2"]
["18.5062","18.7119","18.8795","18.7205",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein export from nucleus;protein import into nucleus;protein sumoylation;regulation of cell cycle;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of mRNA stability;regulation of nucleocytoplasmic transport;RNA export from nucleus;tRNA export from nucleus;viral process;viral transcription","nuclear export signal receptor activity;nuclear localization sequence binding;structural constituent of nuclear pore","cytoplasmic side of nuclear pore;cytosol;focal adhesion;host cell;intracellular membrane-bounded organelle;nuclear pore central transport channel;nuclear pore nuclear basket;nucleoplasm;nucleus","RNA transport",null,null,11,11,11,"8.4","8.4","8.4","213.62",0,"134.84",284090000,33,"0.553383","0.475734","-0.190932","-1.46873","sp|P35658|NU214_HUMAN;tr|A0A0A0MSW3|A0A0A0MSW3_HUMAN;tr|H0Y837|H0Y837_HUMAN;tr|E9PKD2|E9PKD2_HUMAN;tr|B7ZAV2|B7ZAV2_HUMAN;tr|H0YF36|H0YF36_HUMAN","sp|P35658|NU214_HUMAN;tr|A0A0A0MSW3|A0A0A0MSW3_HUMAN",938,"P35658","NU214_HUMAN","Nuclear pore complex protein Nup214",null,"NUP214"]
["19.7529","18.643","19.616","19.1647",{"$nulls":3},"mRNA splicing, via spliceosome;RNA metabolic process","RNA binding","catalytic step 2 spliceosome;intracellular ribonucleoprotein complex;nucleoplasm;nucleus","Spliceosome",null,null,3,3,3,"11.6","11.6","11.6","39.594",0,"9.427",92409000,14,"0.108699","0.909444","-0.192366","-0.321111","sp|P51991|ROA3_HUMAN;tr|H7C1J8|H7C1J8_HUMAN","sp|P51991|ROA3_HUMAN",1150,"P51991","ROA3_HUMAN","Heterogeneous nuclear ribonucleoprotein A3","nRNP A3","HNRNPA3"]
["20.1926","19.9777","20.3831","20.1723",{"$nulls":3},"carnitine metabolic process;carnitine shuttle;cellular response to fatty acid;circadian rhythm;eating behavior;epithelial cell differentiation;fatty acid beta-oxidation;glucose metabolic process;long-chain fatty acid metabolic process;positive regulation of fatty acid beta-oxidation;protein homooligomerization;regulation of insulin secretion;regulation of lipid metabolic process;response to drug;response to organic cyclic compound;triglyceride metabolic process","carnitine O-palmitoyltransferase activity;identical protein binding;palmitoleoyltransferase activity","integral component of mitochondrial outer membrane;membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion","Adipocytokine signaling pathway;AMPK signaling pathway;Fatty acid degradation;Fatty acid metabolism;Glucagon signaling pathway;Insulin resistance;PPAR signaling pathway;Thermogenesis",null,null,6,6,6,"12.2","12.2","12.2","88.367",0,"51.529",337430000,20,"0.48272","0.523627","-0.192575","-1.27961","sp|P50416|CPT1A_HUMAN;tr|H3BP22|H3BP22_HUMAN;tr|H3BUV7|H3BUV7_HUMAN","sp|P50416|CPT1A_HUMAN",1112,"P50416","CPT1A_HUMAN","Carnitine O-palmitoyltransferase 1, liver isoform","PT1-L","CPT1A"]
["20.1385","20.2878","20.7025","20.1096",{"$nulls":3},"covalent chromatin modification;'de novo' cotranslational protein folding;DNA replication;negative regulation of DNA biosynthetic process;positive regulation of transcription, DNA-templated;regulation of cellular response to heat;transcription, DNA-templated","ATPase activator activity;chromatin binding;DNA binding;histone binding;Hsp70 protein binding;RNA binding;ubiquitin modification-dependent histone binding","cytoplasm;cytosol;nuclear membrane;nucleoplasm;nucleus",{"$nulls":3},8,8,8,"16.3","16.3","16.3","71.996",0,"35.181",372600000,26,"0.227243","0.795874","-0.192894","-0.630892","sp|Q99543|DNJC2_HUMAN;tr|C9IZ83|C9IZ83_HUMAN;tr|H7C3L7|H7C3L7_HUMAN","sp|Q99543|DNJC2_HUMAN",2381,"Q99543","DNJC2_HUMAN","DnaJ homolog subfamily C member 2",null,"DNAJC2"]
["18.6411","18.5515","18.8658","18.7128",{"$nulls":9},2,2,2,"10.5","10.5","10.5","25.411",0,"7.4532",69644000,6,"0.792281","0.332939","-0.192986","-2.17768","tr|C9JRD2|C9JRD2_HUMAN;tr|C9JXB9|C9JXB9_HUMAN;sp|P25686|DNJB2_HUMAN;tr|C9J1G2|C9J1G2_HUMAN;tr|E7ETU0|E7ETU0_HUMAN;tr|C9JX00|C9JX00_HUMAN","tr|C9JRD2|C9JRD2_HUMAN;tr|C9JXB9|C9JXB9_HUMAN;sp|P25686|DNJB2_HUMAN;tr|C9J1G2|C9J1G2_HUMAN;tr|E7ETU0|E7ETU0_HUMAN;tr|C9JX00|C9JX00_HUMAN",799,"C9JRD2","C9JRD2_HUMAN",null,null,"DNAJB2"]
["19.2375","19.0689","19.5536","19.139",{"$nulls":3},"abortive mitotic cell cycle;activation of MAPK activity;atrioventricular canal development;axon guidance;Bergmann glial cell differentiation;brain development;cellular response to epidermal growth factor stimulus;cellular response to mechanical stimulus;cerebellar cortex formation;DNA damage checkpoint;ephrin receptor signaling pathway;epidermal growth factor receptor signaling pathway;ERBB signaling pathway;face morphogenesis;fibroblast growth factor receptor signaling pathway;genitalia development;glucose homeostasis;heart development;homeostasis of number of cells within a tissue;hormone metabolic process;hormone-mediated signaling pathway;inner ear development;integrin-mediated signaling pathway;intestinal epithelial cell migration;leukocyte migration;megakaryocyte development;microvillus organization;multicellular organism growth;multicellular organismal reproductive process;negative regulation of cell adhesion mediated by integrin;negative regulation of cortisol secretion;negative regulation of growth hormone secretion;negative regulation of insulin secretion;neurotrophin TRK receptor signaling pathway;organ growth;peptidyl-tyrosine dephosphorylation;platelet activation;platelet formation;platelet-derived growth factor receptor signaling pathway;positive regulation of ERK1 and ERK2 cascade;positive regulation of glucose import in response to insulin stimulus;positive regulation of hormone secretion;positive regulation of mitotic cell cycle;positive regulation of protein kinase B signaling;regulation of cell adhesion mediated by integrin;regulation of multicellular organism growth;regulation of protein complex assembly;regulation of protein export from nucleus;regulation of type I interferon-mediated signaling pathway;T cell costimulation;triglyceride metabolic process","1-phosphatidylinositol-3-kinase activity;cell adhesion molecule binding;D1 dopamine receptor binding;insulin receptor binding;insulin receptor substrate binding;non-membrane spanning protein tyrosine phosphatase activity;peptide hormone receptor binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;phospholipase binding;phosphoprotein phosphatase activity;protein domain specific binding;protein tyrosine phosphatase activity;receptor tyrosine kinase binding;SH3/SH2 adaptor activity","cytoplasm;cytosol;mitochondrion;nucleoplasm;nucleus;protein complex","Adipocytokine signaling pathway;Axon guidance;Chronic myeloid leukemia;C-type lectin receptor signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Herpes simplex virus 1 infection;Insulin resistance;Jak-STAT signaling pathway;Leukocyte transendothelial migration;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;Proteoglycans in cancer;Ras signaling pathway;Renal cell carcinoma",null,null,7,7,7,"15.9","15.9","15.9","68.436",0,"18.678",251630000,35,"0.319517","0.710034","-0.193113","-0.862849","sp|Q06124|PTN11_HUMAN;tr|H0YF12|H0YF12_HUMAN","sp|Q06124|PTN11_HUMAN",1455,"Q06124","PTN11_HUMAN","Tyrosine-protein phosphatase non-receptor type 11",null,"PTPN11"]
["18.4736",1,"18.8614",1,{"$nulls":9},1,1,1,"12.3","12.3","12.3","11.848","0.0011066","2.7062",5105200,2,"0.00479188","0.990664","-0.19389","-0.0155192","tr|A0A087WW12|A0A087WW12_HUMAN;tr|A0A087WZ11|A0A087WZ11_HUMAN;sp|Q6P158|DHX57_HUMAN","tr|A0A087WW12|A0A087WW12_HUMAN;tr|A0A087WZ11|A0A087WZ11_HUMAN;sp|Q6P158|DHX57_HUMAN",1880,"A0A087WW12","A0A087WW12_HUMAN",null,null,"DHX57"]
["22.2385","22.2371","22.8049","22.0586",{"$nulls":9},4,4,4,"36.1","36.1","36.1","14.117",0,"7.1274",307260000,12,"0.183729","0.83292","-0.193946","-0.519742","tr|H7C5M9|H7C5M9_HUMAN;tr|C9JSA3|C9JSA3_HUMAN;tr|C9JND6|C9JND6_HUMAN;tr|C9J6F3|C9J6F3_HUMAN;tr|C9J5C3|C9J5C3_HUMAN;sp|Q9BUL8|PDC10_HUMAN;tr|C9J363|C9J363_HUMAN;tr|F8WDF3|F8WDF3_HUMAN;tr|C9J932|C9J932_HUMAN","tr|H7C5M9|H7C5M9_HUMAN;tr|C9JSA3|C9JSA3_HUMAN;tr|C9JND6|C9JND6_HUMAN;tr|C9J6F3|C9J6F3_HUMAN;tr|C9J5C3|C9J5C3_HUMAN;sp|Q9BUL8|PDC10_HUMAN;tr|C9J363|C9J363_HUMAN",2457,"H7C5M9","H7C5M9_HUMAN",null,null,"PDCD10"]
[1,"17.1359",1,"17.5244",{"$nulls":4},"RNA binding",{"$nulls":4},1,1,1,"4.4","4.4","4.4","29.328","0.00076104","2.9078",12637000,1,"0.00519657","0.990837","-0.194263","-0.0168222","tr|Q5SY38|Q5SY38_HUMAN;sp|P41214|EIF2D_HUMAN","tr|Q5SY38|Q5SY38_HUMAN;sp|P41214|EIF2D_HUMAN",981,"Q5SY38","Q5SY38_HUMAN",null,null,"EIF2D"]
["21.0977","21.0861","21.5981","20.9752",{"$nulls":3},"cholesterol biosynthetic process;fatty acid beta-oxidation;lipid metabolic process","acetyl-CoA C-acetyltransferase activity","cytoplasm;cytosol;extracellular exosome;mitochondrion;nucleolus;nucleus","Butanoate metabolism;Carbon metabolism;Fat digestion and absorption;Fatty acid degradation;Fatty acid metabolism;Glyoxylate and dicarboxylate metabolism;Lysine degradation;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism;Synthesis and degradation of ketone bodies;Terpenoid backbone biosynthesis;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,7,7,7,"31.2","31.2","31.2","41.35",0,"238.4",514880000,55,"0.225002","0.796603","-0.194772","-0.625212","sp|Q9BWD1|THIC_HUMAN","sp|Q9BWD1|THIC_HUMAN",2483,"Q9BWD1","THIC_HUMAN","Acetyl-CoA acetyltransferase, cytosolic",null,"ACAT2"]
["18.4757","18.4116","19.0852","18.1917",{"$nulls":3},"nucleotide-excision repair, DNA damage recognition;post-translational protein modification;protein deneddylation;transcription-coupled nucleotide-excision repair","NEDD8-specific protease activity","cell junction;COP9 signalosome;cytosol;extracellular exosome;nuclear speck;nucleoplasm;nucleus;synaptic vesicle",{"$nulls":3},4,4,4,"14.5","14.5","14.5","46.268",0,"16.171",86967000,15,"0.151193","0.876543","-0.194836","-0.434999","sp|Q9BT78|CSN4_HUMAN;tr|D6RAX7|D6RAX7_HUMAN;tr|D6RFN0|D6RFN0_HUMAN;tr|D6RD63|D6RD63_HUMAN","sp|Q9BT78|CSN4_HUMAN;tr|D6RAX7|D6RAX7_HUMAN;tr|D6RFN0|D6RFN0_HUMAN;tr|D6RD63|D6RD63_HUMAN",2441,"Q9BT78","CSN4_HUMAN","COP9 signalosome complex subunit 4","GN4;ignalosome subunit 4","COPS4"]
["19.2265","18.484","19.6234","18.4769",{"$nulls":3},"chemical synaptic transmission;exocytosis;Golgi to plasma membrane transport;paraxial mesoderm formation;protein targeting to membrane;regulation of macroautophagy;vesicle docking involved in exocytosis;vesicle targeting","PDZ domain binding;protein N-terminus binding;Ral GTPase binding","cytoplasm;cytosol;exocyst;Flemming body;growth cone membrane;membrane;microvillus;myelin sheath abaxonal region;plasma membrane;synapse",{"$nulls":3},10,10,10,"14.5","14.5","14.5","110.5",0,110,336950000,45,"0.0957032","0.918746","-0.194877","-0.28533","sp|Q96A65|EXOC4_HUMAN","sp|Q96A65|EXOC4_HUMAN",2229,"Q96A65","EXOC4_HUMAN","Exocyst complex component 4",null,"EXOC4"]
["23.1266","22.7946","23.5892","22.7229",{"$nulls":9},11,11,11,"50.6","50.6","50.6","31.595",0,"323.31",2192700000,90,"0.146029","0.877942","-0.195459","-0.421377","tr|A0A087WZH7|A0A087WZH7_HUMAN;sp|P29966|MARCS_HUMAN","tr|A0A087WZH7|A0A087WZH7_HUMAN;sp|P29966|MARCS_HUMAN",851,"A0A087WZH7"]
["24.5556","24.6699","25.1018","24.5153",{"$nulls":3},"CRD-mediated mRNA stabilization;in utero embryonic development;mRNA splicing, via spliceosome;negative regulation of striated muscle cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell division;positive regulation of transcription from RNA polymerase II promoter;protein localization to cytoplasmic stress granule;regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter","chromatin binding;DNA binding;DNA binding transcription factor activity;double-stranded DNA binding;GTPase binding;RNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;single-stranded DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","CRD-mediated mRNA stability complex;cytoplasm;cytoplasmic stress granule;cytosol;extracellular exosome;histone pre-mRNA 3'end processing complex;intracellular membrane-bounded organelle;intracellular ribonucleoprotein complex;nuclear membrane;nucleoplasm;nucleus;U12-type spliceosomal complex",{"$nulls":3},15,15,12,"60.2","60.2","49.1","35.924",0,"323.31",3914300000,142,"0.236929","0.788671","-0.195793","-0.655396","sp|P67809|YBOX1_HUMAN;tr|A0A087X1S2|A0A087X1S2_HUMAN;tr|H0Y449|H0Y449_HUMAN;tr|C9J5V9|C9J5V9_HUMAN","sp|P67809|YBOX1_HUMAN;tr|A0A087X1S2|A0A087X1S2_HUMAN;tr|H0Y449|H0Y449_HUMAN;tr|C9J5V9|C9J5V9_HUMAN",1352,"P67809","YBOX1_HUMAN","Nuclease-sensitive element-binding protein 1",null,"YBX1"]
["23.7033","23.605","24.2075","23.4939",{"$nulls":3},"mitochondrial transport;transport","phosphate:proton symporter activity;protein complex binding","extracellular exosome;integral component of plasma membrane;membrane;mitochondrial inner membrane;mitochondrion;myelin sheath",{"$nulls":3},4,4,4,"9.9","9.9","9.9","40.094",0,"8.0025",2473700000,18,"0.193778","0.828748","-0.196528","-0.545597","sp|Q00325|MPCP_HUMAN;tr|F8VVM2|F8VVM2_HUMAN","sp|Q00325|MPCP_HUMAN;tr|F8VVM2|F8VVM2_HUMAN",1401,"Q00325","MPCP_HUMAN","Phosphate carrier protein, mitochondrial",null,"SLC25A3"]
["17.1483","16.6128","17.276","16.8784",{"$nulls":3},"acetyl-CoA biosynthetic process;acyl-CoA metabolic process;fatty acid biosynthetic process;fatty acid oxidation;malonyl-CoA catabolic process;positive regulation of fatty acid oxidation;regulation of fatty acid beta-oxidation;regulation of glucose metabolic process;response to ischemia","identical protein binding;malonyl-CoA decarboxylase activity;receptor binding","cytoplasm;cytosol;mitochondrial matrix;mitochondrion;peroxisomal matrix;peroxisome","AMPK signaling pathway;beta-Alanine metabolism;Metabolic pathways;Peroxisome;Propanoate metabolism",null,null,1,1,1,"2.2","2.2","2.2","55.003","0.0076008","1.784",27791000,5,"0.211077","0.813321","-0.19669","-0.589826","sp|O95822|DCMC_HUMAN","sp|O95822|DCMC_HUMAN",452,"O95822","DCMC_HUMAN","Malonyl-CoA decarboxylase, mitochondrial","CD","MLYCD"]
["21.7151","21.073","21.7135","21.4691",{"$nulls":3},"defense response to virus;negative regulation of transcription, DNA-templated;negative regulation of translation;negative regulation of viral genome replication;positive regulation of transcription, DNA-templated;protein phosphorylation;transcription, DNA-templated","DNA binding;double-stranded RNA binding;RNA binding","cytoplasm;extracellular region;intracellular ribonucleoprotein complex;membrane;mitochondrion;nucleolus;nucleoplasm;nucleus",{"$nulls":3},12,12,12,18,18,18,"95.337",0,"63.863",936770000,46,"0.204996","0.818348","-0.19728","-0.574316","sp|Q12906|ILF3_HUMAN;tr|K7EQR9|K7EQR9_HUMAN;tr|K7EKJ9|K7EKJ9_HUMAN;sp|Q96SI9|STRBP_HUMAN;tr|K7EKY0|K7EKY0_HUMAN;tr|K7ER69|K7ER69_HUMAN","sp|Q12906|ILF3_HUMAN",1505,"Q12906","ILF3_HUMAN","Interleukin enhancer-binding factor 3",null,"ILF3"]
["21.8187","21.7445","22.2651","21.693",{"$nulls":3},"cell redox homeostasis;cellular response to oxidative stress","disulfide oxidoreductase activity;oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;protein disulfide oxidoreductase activity;protein-disulfide reductase activity;thioredoxin-disulfide reductase activity","cytoplasm;cytosol;extracellular exosome;nucleus;proteasome complex",{"$nulls":3},9,9,9,"43.6","43.6","43.6","32.251",0,"143.15",567800000,45,"0.24846","0.777912","-0.197438","-0.684491","sp|O43396|TXNL1_HUMAN;tr|K7ER96|K7ER96_HUMAN;tr|K7EML9|K7EML9_HUMAN;tr|K7EPB7|K7EPB7_HUMAN;tr|K7EKG2|K7EKG2_HUMAN;tr|K7EME7|K7EME7_HUMAN","sp|O43396|TXNL1_HUMAN;tr|K7ER96|K7ER96_HUMAN",245,"O43396","TXNL1_HUMAN","Thioredoxin-like protein 1",null,"TXNL1"]
["22.6736","22.6852","23.1439","22.6118",{"$nulls":9},1,1,1,"14.1","14.1","14.1","9.9994",0,"22.755",137500000,6,"0.272769","0.755219","-0.198443","-0.745619","tr|E9PJB2|E9PJB2_HUMAN;tr|E9PPG8|E9PPG8_HUMAN;sp|Q53FT3|HIKES_HUMAN","tr|E9PJB2|E9PJB2_HUMAN;tr|E9PPG8|E9PPG8_HUMAN;sp|Q53FT3|HIKES_HUMAN",1793,"E9PJB2","E9PJB2_HUMAN",null,null,"HIKESHI"]
["22.7986","23.03","23.1731","23.0535",{"$nulls":3},"post-chaperonin tubulin folding pathway;tubulin complex assembly","beta-tubulin binding","cytoplasm;microtubule;microtubule cytoskeleton;nucleolus",{"$nulls":3},4,4,4,"48.8","48.8","48.8","10.08",0,"23.789",550980000,31,"0.574751","0.463507","-0.198979","-1.52741","tr|E5RIW3|E5RIW3_HUMAN;sp|O75347|TBCA_HUMAN;tr|E5RJD8|E5RJD8_HUMAN;tr|E5RHG6|E5RHG6_HUMAN;tr|E5RIX8|E5RIX8_HUMAN","tr|E5RIW3|E5RIW3_HUMAN;sp|O75347|TBCA_HUMAN;tr|E5RJD8|E5RJD8_HUMAN;tr|E5RHG6|E5RHG6_HUMAN;tr|E5RIX8|E5RIX8_HUMAN",332,"E5RIW3","E5RIW3_HUMAN","Tubulin-specific chaperone A {ECO:0000256|RuleBase:RU364030}",null,"TBCA"]
["21.202","20.8574","21.4996","20.9579",{"$nulls":3},"cytokinetic process;phagocytosis;response to calcium ion","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;MHC class II protein complex binding;phosphatidylethanolamine binding;RNA binding;S100 protein binding","azurophil granule;cytoplasm;cytosol;extracellular exosome;melanosome;membrane;midbody;nuclear envelope;nucleoplasm;phagocytic vesicle;specific granule;spindle",{"$nulls":3},7,7,7,17,17,17,"54.389",0,"13.557",444180000,22,"0.222948","0.800698","-0.199015","-0.620002","sp|P50995|ANX11_HUMAN;tr|H0Y6E1|H0Y6E1_HUMAN;tr|E5RIN3|E5RIN3_HUMAN;sp|P27216|ANX13_HUMAN","sp|P50995|ANX11_HUMAN",1126,"P50995","ANX11_HUMAN","Annexin A11",null,"ANXA11"]
["24.1112","23.801","24.5091","23.8013",{"$nulls":3},"glutathione metabolic process;response to virus;translational elongation","cadherin binding;glutathione transferase activity;translation elongation factor activity","cytoplasm;cytosol;extracellular exosome;membrane;nucleus","Legionellosis",null,null,17,17,17,"43.5","43.5","43.5","50.118",0,"194.23",4095900000,128,"0.181977","0.835767","-0.199059","-0.515221","sp|P26641|EF1G_HUMAN","sp|P26641|EF1G_HUMAN",817,"P26641","EF1G_HUMAN","Elongation factor 1-gamma","F-1-gamma","EEF1G"]
["17.0202","17.5257","17.2532","17.6913",{"$nulls":3},"cellular response to drug;mRNA processing;mRNA splicing, via spliceosome;response to cocaine;RNA splicing","GTP binding;GTPase activity;RNA binding","Cajal body;catalytic step 2 spliceosome;cytosol;extracellular matrix;membrane;nuclear speck;nucleoplasm;spliceosomal complex;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,4,3,3,"5.3","4.3","4.3","109.43",0,"10.122",86903000,17,"0.213491","0.808233","-0.199308","-0.595972","sp|Q15029|U5S1_HUMAN","sp|Q15029|U5S1_HUMAN",1665,"Q15029","U5S1_HUMAN","116 kDa U5 small nuclear ribonucleoprotein component",null,"EFTUD2"]
["22.7739","22.5304","23.0287","22.6747",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of endopeptidase activity;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of G1/S transition of mitotic cell cycle;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of proteasomal protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activator activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm;proteasome activator complex;proteasome complex","Antigen processing and presentation;Proteasome",null,null,10,10,10,"45.8","45.8","45.8","28.723",0,"46.795",1003100000,41,"0.345888","0.688595","-0.199598","-0.929072","sp|Q06323|PSME1_HUMAN;tr|H0YLU2|H0YLU2_HUMAN;tr|H0YKK6|H0YKK6_HUMAN","sp|Q06323|PSME1_HUMAN;tr|H0YLU2|H0YLU2_HUMAN",1459,"Q06323","PSME1_HUMAN","Proteasome activator complex subunit 1",null,"PSME1"]
["23.9618","23.8731","24.6178","23.6174",{"$nulls":3},"branched-chain amino acid catabolic process;lipid metabolic process;mitochondrial tRNA 3'-end processing;mitochondrial tRNA 5'-end processing;mitochondrial tRNA methylation;mitochondrial tRNA processing;mitochondrion organization;protein homotetramerization","3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity;3-hydroxyacyl-CoA dehydrogenase activity;cholate 7-alpha-dehydrogenase activity;RNA binding;testosterone dehydrogenase [NAD(P)] activity;tRNA binding","cytoplasm;mitochondrial matrix;mitochondrial ribonuclease P complex;mitochondrion;plasma membrane","Alzheimer disease;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,12,12,12,77,77,77,"26.923",0,"212.17",2180500000,120,"0.137406","0.891422","-0.200112","-0.398506","sp|Q99714|HCD2_HUMAN;tr|Q5H928|Q5H928_HUMAN","sp|Q99714|HCD2_HUMAN;tr|Q5H928|Q5H928_HUMAN",2392,"Q99714","HCD2_HUMAN","3-hydroxyacyl-CoA dehydrogenase type-2",null,"HSD17B10"]
["23.0615","22.6928","23.2818","22.8728",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of protein targeting to mitochondrion;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex;secretory granule lumen","Proteasome",null,null,6,6,6,"28.5","28.5","28.5","29.965",0,"72.324",891670000,65,"0.265352","0.756193","-0.200162","-0.726993","sp|Q99436|PSB7_HUMAN;tr|Q5TBG5|Q5TBG5_HUMAN","sp|Q99436|PSB7_HUMAN",2369,"Q99436","PSB7_HUMAN","Proteasome subunit beta type-7",null,"PSMB7"]
["23.6287","23.4505","23.6793","23.8003",{"$nulls":3},"translation","rRNA binding;structural constituent of ribosome","small ribosomal subunit","Ribosome",null,null,7,7,7,"26.8","26.8","26.8","22.591",0,"9.1391",1576400000,22,"0.690086","0.373148","-0.200188","-1.85892","tr|A0A024R4M0|A0A024R4M0_HUMAN;sp|P46781|RS9_HUMAN;tr|B5MCT8|B5MCT8_HUMAN;tr|C9JM19|C9JM19_HUMAN;tr|F2Z3C0|F2Z3C0_HUMAN;tr|A8MXK4|A8MXK4_HUMAN","tr|A0A024R4M0|A0A024R4M0_HUMAN;sp|P46781|RS9_HUMAN;tr|B5MCT8|B5MCT8_HUMAN;tr|C9JM19|C9JM19_HUMAN",1035,"A0A024R4M0","A0A024R4M0_HUMAN"]
["24.3522","24.257","24.2888","24.721",{"$nulls":3},"cellular response to interleukin-6;DNA biosynthetic process;histone deacetylation;mitochondrial calcium ion transmembrane transport;mitochondrion organization;negative regulation of androgen receptor signaling pathway;negative regulation of cell growth;negative regulation of cell proliferation;negative regulation of ERK1 and ERK2 cascade;negative regulation of glucocorticoid receptor signaling pathway;negative regulation of protein catabolic process;negative regulation of transcription by competitive promoter binding;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;osteoblast differentiation;positive regulation of cell death;positive regulation of complement activation;positive regulation of ERK1 and ERK2 cascade;positive regulation of gene expression;positive regulation of G-protein coupled receptor protein signaling pathway;positive regulation of transcription, DNA-templated;progesterone receptor signaling pathway;protein stabilization;regulation of apoptotic process;regulation of transcription, DNA-templated;signal transduction","complement component C3a binding;complement component C3b binding;enzyme binding;histone deacetylase binding;protein C-terminus binding;proteinase activated receptor binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcription regulatory region DNA binding","cell surface;cytoplasm;early endosome;extracellular exosome;integral component of plasma membrane;membrane;mitochondrial inner membrane;mitochondrion;myelin sheath;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},15,15,15,"62.9","62.9","62.9","29.804",0,"176.32",3384100000,118,"0.336452","0.696985","-0.200332","-0.905353","sp|P35232|PHB_HUMAN;tr|C9JW96|C9JW96_HUMAN;tr|C9JZ20|C9JZ20_HUMAN;tr|E7ESE2|E7ESE2_HUMAN;tr|E9PCW0|E9PCW0_HUMAN;tr|D6RBK0|D6RBK0_HUMAN","sp|P35232|PHB_HUMAN;tr|C9JW96|C9JW96_HUMAN;tr|C9JZ20|C9JZ20_HUMAN;tr|E7ESE2|E7ESE2_HUMAN;tr|E9PCW0|E9PCW0_HUMAN",922,"P35232","PHB_HUMAN","Prohibitin",null,"PHB"]
["23.3051","23.1236","23.5581","23.2716",{"$nulls":5},"cytosol;nucleoplasm;plasma membrane",{"$nulls":3},2,2,2,"6.5","6.5","6.5","37.504",0,"108.95",1015300000,11,"0.445376","0.556685","-0.200524","-1.18228","tr|A0A087WX59|A0A087WX59_HUMAN;sp|Q16186|ADRM1_HUMAN","tr|A0A087WX59|A0A087WX59_HUMAN;sp|Q16186|ADRM1_HUMAN",1732,"A0A087WX59","A0A087WX59_HUMAN",null,null,"ADRM1"]
["26.9864","26.8403","27.3486","26.8798",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic mitochondrial changes;B cell activation;B cell cytokine production;B cell proliferation;chaperone-mediated protein complex assembly;chaperone-mediated protein folding;'de novo' protein folding;interaction with symbiont;isotype switching to IgG isotypes;MyD88-dependent toll-like receptor signaling pathway;negative regulation of apoptotic process;positive regulation of apoptotic process;positive regulation of interferon-alpha production;positive regulation of interferon-gamma production;positive regulation of interleukin-10 production;positive regulation of interleukin-12 production;positive regulation of interleukin-6 production;positive regulation of macrophage activation;positive regulation of T cell activation;positive regulation of T cell mediated immune response to tumor cell;protein import into mitochondrial intermembrane space;protein maturation;protein refolding;protein stabilization;regulation of transcription from RNA polymerase II promoter;response to cold;response to unfolded protein;T cell activation;viral process","apolipoprotein A-I binding;apolipoprotein binding;ATP binding;ATPase activity;chaperone binding;DNA replication origin binding;double-stranded RNA binding;enzyme binding;high-density lipoprotein particle binding;lipopolysaccharide binding;p53 binding;protein binding involved in protein folding;RNA binding;single-stranded DNA binding;ubiquitin protein ligase binding;unfolded protein binding","cell surface;clathrin-coated pit;coated vesicle;cytoplasm;cytosol;early endosome;extracellular exosome;extracellular matrix;extracellular space;lipopolysaccharide receptor complex;membrane;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;myelin sheath;plasma membrane;protein complex;secretory granule","Legionellosis;RNA degradation;Tuberculosis;Type I diabetes mellitus",null,null,31,31,31,67,67,67,"61.054",0,"323.31",36973000000,402,"0.301685","0.728074","-0.200859","-0.818139","sp|P10809|CH60_HUMAN;tr|E7ESH4|E7ESH4_HUMAN;tr|E7EXB4|E7EXB4_HUMAN;tr|C9JL25|C9JL25_HUMAN;tr|C9JL19|C9JL19_HUMAN;tr|C9JCQ4|C9JCQ4_HUMAN;tr|C9J0S9|C9J0S9_HUMAN","sp|P10809|CH60_HUMAN",613,"P10809","CH60_HUMAN","60 kDa heat shock protein, mitochondrial",null,"HSPD1"]
["23.5066","23.1707","23.746","23.3336",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","RNA binding;threonine-type endopeptidase activity","centrosome;cytosol;extracellular exosome;nucleoplasm;nucleus;polysome;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex","Proteasome",null,null,8,8,8,"40.3","40.3","40.3","29.555",0,"96.013",2053700000,44,"0.277031","0.753265","-0.201154","-0.756316","sp|P25786|PSA1_HUMAN;tr|F5GX11|F5GX11_HUMAN;tr|B4DEV8|B4DEV8_HUMAN","sp|P25786|PSA1_HUMAN;tr|F5GX11|F5GX11_HUMAN;tr|B4DEV8|B4DEV8_HUMAN",801,"P25786","PSA1_HUMAN","Proteasome subunit alpha type-1",null,"PSMA1"]
["19.0702","19.1893","19.3484","19.315",{"$nulls":5},"nucleoplasm",{"$nulls":3},2,2,2,"8.5","8.5","8.5","43.404",0,"86.663",94808000,13,"1.0842","0.308473","-0.201988","-3.26511","tr|G3V5E1|G3V5E1_HUMAN;sp|O75909|CCNK_HUMAN;tr|G3V235|G3V235_HUMAN;tr|G3V2Q3|G3V2Q3_HUMAN","tr|G3V5E1|G3V5E1_HUMAN;sp|O75909|CCNK_HUMAN;tr|G3V235|G3V235_HUMAN;tr|G3V2Q3|G3V2Q3_HUMAN",376,"G3V5E1","G3V5E1_HUMAN",null,null,"CCNK"]
["16.4681","16.704","16.4774","17.1002",{"$nulls":3},"embryo development ending in birth or egg hatching;epithelial cell-cell adhesion;establishment of epithelial cell apical/basal polarity;establishment or maintenance of microtubule cytoskeleton polarity;microtubule anchoring;microtubule cytoskeleton organization;negative regulation of phosphatase activity;neuron projection development;protein transport along microtubule;regulation of cell migration;regulation of focal adhesion assembly;regulation of Golgi organization;regulation of microtubule cytoskeleton organization;regulation of microtubule polymerization;regulation of organelle organization;zonula adherens maintenance","actin filament binding;calmodulin binding;microtubule minus-end binding;spectrin binding","cytoplasm;microtubule;zonula adherens",{"$nulls":3},2,2,2,"2.6","2.6","2.6","134.75",0,"20.763",48286000,11,"0.218526","0.802162","-0.202724","-0.608777","sp|Q9P1Y5|CAMP3_HUMAN","sp|Q9P1Y5|CAMP3_HUMAN",2778,"Q9P1Y5","CAMP3_HUMAN","Calmodulin-regulated spectrin-associated protein 3 {ECO:0000305}",null,"CAMSAP3"]
["21.8631","22.0513","22.8751","21.4453",{"$nulls":3},"adenine transport;behavioral fear response;learning;neuron-neuron synaptic transmission;regulation of cilium assembly","nucleotide binding;porin activity;voltage-gated anion channel activity","extracellular exosome;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion;nucleus;pore complex","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholesterol metabolism;Ferroptosis;Hepatitis B;Human T-cell leukemia virus 1 infection;Huntington disease;Necroptosis;NOD-like receptor signaling pathway;Parkinson disease;Viral carcinogenesis",null,null,6,6,6,"27.2","27.2","27.2","30.658",0,"25.801",600120000,24,"0.0943448","0.920733","-0.203019","-0.28156","sp|Q9Y277|VDAC3_HUMAN;tr|E5RK27|E5RK27_HUMAN;tr|E5RFP6|E5RFP6_HUMAN;tr|E5RJN6|E5RJN6_HUMAN;tr|E5RHZ6|E5RHZ6_HUMAN;tr|E5RHE1|E5RHE1_HUMAN","sp|Q9Y277|VDAC3_HUMAN",2943,"Q9Y277","VDAC3_HUMAN","Voltage-dependent anion-selective channel protein 3","DAC-3;VDAC3","VDAC3"]
["21.1286","21.2956","21.8197","21.0119",{"$nulls":3},"early endosome to Golgi transport;endocytosis;intracellular protein transport;lamellipodium morphogenesis;protein oligomerization;retrograde transport, endosome to Golgi;vesicle organization","cadherin binding;epidermal growth factor receptor binding;insulin receptor binding;leptin receptor binding;phosphatidylinositol binding;protein heterodimerization activity;protein homodimerization activity;transferrin receptor binding","cytoplasm;cytosol;early endosome membrane;endosome;endosome membrane;extracellular exosome;extrinsic component of membrane;lamellipodium;lysosome;membrane;protein complex;retromer complex;retromer, tubulation complex","Endocytosis",null,null,9,9,9,"21.6","21.6","21.6","58.47",0,"44.141",678170000,46,"0.173722","0.848585","-0.203684","-0.493857","sp|O60749|SNX2_HUMAN;tr|D6RC15|D6RC15_HUMAN","sp|O60749|SNX2_HUMAN",302,"O60749","SNX2_HUMAN","Sorting nexin-2",null,"SNX2"]
["21.5028","21.5094","22.0416","21.3781",{"$nulls":3},"cellular iron ion homeostasis;cellular response to increased oxygen levels;insulin receptor signaling pathway;ion transmembrane transport;phagosome acidification;regulation of macroautophagy;transferrin transport","ATPase binding;hydrogen-exporting ATPase activity, phosphorylative mechanism","cytosol;extracellular exosome;lysosomal membrane;plasma membrane;vacuolar proton-transporting V-type ATPase complex","Collecting duct acid secretion;Epithelial cell signaling in Helicobacter pylori infection;Human papillomavirus infection;Metabolic pathways;mTOR signaling pathway;Oxidative phosphorylation;Phagosome;Rheumatoid arthritis;Synaptic vesicle cycle;Vibrio cholerae infection",null,null,3,3,3,"29.7","29.7","29.7","13.757",0,"51.259",289550000,11,"0.220623","0.801572","-0.203741","-0.614102","sp|O75348|VATG1_HUMAN;tr|F2Z307|F2Z307_HUMAN;sp|O95670|VATG2_HUMAN","sp|O75348|VATG1_HUMAN",333,"O75348","VATG1_HUMAN","V-type proton ATPase subunit G 1","-ATPase subunit G 1","ATP6V1G1"]
["19.823","19.1982","19.9128","19.5159",{"$nulls":3},"galactose catabolic process via UDP-galactose;galactose metabolic process;glucose metabolic process","aldose 1-epimerase activity;carbohydrate binding","cytoplasm;extracellular exosome","Galactose metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways",null,null,2,2,2,"8.5","8.5","8.5","37.765",0,"4.8937",116280000,10,"0.195691","0.826482","-0.20375","-0.550505","sp|Q96C23|GALM_HUMAN;tr|H7C320|H7C320_HUMAN;tr|B8ZZ75|B8ZZ75_HUMAN;tr|H7C1B5|H7C1B5_HUMAN","sp|Q96C23|GALM_HUMAN;tr|H7C320|H7C320_HUMAN;tr|B8ZZ75|B8ZZ75_HUMAN;tr|H7C1B5|H7C1B5_HUMAN",2242,"Q96C23","GALM_HUMAN","Aldose 1-epimerase",null,"GALM"]
["20.1963","20.1265","20.4067","20.3248",{"$nulls":3},"ATP hydrolysis coupled proton transport;ATP metabolic process;cellular iron ion homeostasis;cellular response to increased oxygen levels;insulin receptor signaling pathway;ion transmembrane transport;phagosome acidification;regulation of macroautophagy;transferrin transport;transport","ATP binding;proton-transporting ATPase activity, rotational mechanism","apical plasma membrane;cytosol;extracellular exosome;integral component of plasma membrane;lysosomal membrane;microvillus;mitochondrion;myelin sheath;plasma membrane;proton-transporting two-sector ATPase complex;proton-transporting V-type ATPase, V1 domain","Collecting duct acid secretion;Epithelial cell signaling in Helicobacter pylori infection;Human papillomavirus infection;Metabolic pathways;mTOR signaling pathway;Oxidative phosphorylation;Phagosome;Rheumatoid arthritis;Synaptic vesicle cycle;Vibrio cholerae infection",null,null,9,9,9,"21.6","21.6","21.6","68.303",0,"72.619",439340000,36,"1.20174","0.326975","-0.204298","-3.79851","sp|P38606|VATA_HUMAN;tr|C9JA17|C9JA17_HUMAN;tr|C9JVW8|C9JVW8_HUMAN","sp|P38606|VATA_HUMAN",958,"P38606","VATA_HUMAN","V-type proton ATPase catalytic subunit A",{"$f":"-ATPase subunit A","v":{"$error":"#NAME?"}},"ATP6V1A"]
["19.1515","19.3498","19.9418","18.969",{"$nulls":3},"signal transduction",{"$nulls":5},1,1,1,7,7,7,"29.168","0.000387","3.0766",83605000,6,"0.14263","0.883004","-0.204703","-0.412379","tr|E9PM35|E9PM35_HUMAN;sp|P49407|ARRB1_HUMAN","tr|E9PM35|E9PM35_HUMAN;sp|P49407|ARRB1_HUMAN",1076,"E9PM35","E9PM35_HUMAN",null,null,"ARRB1"]
["21.3204","21.8884","21.8331","21.7857",{"$nulls":3},"actin cytoskeleton organization;actin filament branching;actin filament bundle assembly;actin filament organization;adherens junction organization;blood coagulation;canonical Wnt signaling pathway;cardiac conduction system development;Cdc42 protein signal transduction;cell junction assembly;cellular protein localization;cellular response to interferon-gamma;dendritic cell migration;dendritic spine morphogenesis;ephrin receptor signaling pathway;epithelial cell-cell adhesion;epithelial-mesenchymal cell signaling;establishment of epithelial cell apical/basal polarity;establishment of Golgi localization;establishment or maintenance of cell polarity;Fc-gamma receptor signaling pathway involved in phagocytosis;filopodium assembly;Golgi organization;hair follicle morphogenesis;hair follicle placode formation;heart contraction;integrin-mediated signaling pathway;interleukin-12-mediated signaling pathway;keratinization;keratinocyte development;macrophage differentiation;modification of synaptic structure;multicellular organism growth;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of gene expression;negative regulation of protein complex assembly;neuron fate determination;neuropilin signaling pathway;nuclear migration;organelle transport along microtubule;phagocytosis, engulfment;positive regulation of actin cytoskeleton reorganization;positive regulation of cell growth;positive regulation of cytokinesis;positive regulation of DNA replication;positive regulation of epithelial cell proliferation involved in lung morphogenesis;positive regulation of filopodium assembly;positive regulation of gene expression;positive regulation of hair follicle cell proliferation;positive regulation of intracellular protein transport;positive regulation of JNK cascade;positive regulation of lamellipodium assembly;positive regulation of muscle cell differentiation;positive regulation of neuron apoptotic process;positive regulation of peptidyl-serine phosphorylation;positive regulation of phosphatidylinositol 3-kinase activity;positive regulation of pseudopodium assembly;positive regulation of stress fiber assembly;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of synapse structural plasticity;regulation of attachment of spindle microtubules to kinetochore;regulation of filopodium assembly;regulation of lamellipodium assembly;regulation of mitotic nuclear division;regulation of protein catabolic process;regulation of protein heterodimerization activity;regulation of protein kinase activity;regulation of protein stability;regulation of small GTPase mediated signal transduction;regulation of stress fiber assembly;sprouting angiogenesis;submandibular salivary gland formation;substantia nigra development;T cell costimulation;vascular endothelial growth factor receptor signaling pathway;viral RNA genome replication;Wnt signaling pathway, planar cell polarity pathway","apolipoprotein A-I receptor binding;GBD domain binding;GTP binding;GTPase activity;GTP-dependent protein binding;identical protein binding;mitogen-activated protein kinase kinase kinase binding;protein kinase binding;protein serine/threonine kinase activity;Rho GDP-dissociation inhibitor binding;thioesterase binding;ubiquitin protein ligase activity","apical part of cell;cell-cell junction;cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;dendritic spine;endoplasmic reticulum membrane;extracellular exosome;filopodium;focal adhesion;Golgi membrane;Golgi transport complex;leading edge membrane;membrane;microtubule organizing center;midbody;mitotic spindle;myelin sheath;neuron projection;neuronal cell body;phagocytic vesicle;plasma membrane;protein complex;secretory granule;spindle midzone;storage vacuole","Adherens junction;AGE-RAGE signaling pathway in diabetic complications;Axon guidance;Bacterial invasion of epithelial cells;Chemokine signaling pathway;Endocytosis;Epithelial cell signaling in Helicobacter pylori infection;Fc gamma R-mediated phagocytosis;Focal adhesion;GnRH signaling pathway;Human papillomavirus infection;Leukocyte transendothelial migration;MAPK signaling pathway;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Salmonella infection;Shigellosis;T cell receptor signaling pathway;Tight junction;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,4,4,4,"29.8","29.8","29.8","21.258",0,"48.154",264550000,16,"0.262352","0.760067","-0.205018","-0.719452","sp|P60953|CDC42_HUMAN;tr|Q5JYX0|Q5JYX0_HUMAN","sp|P60953|CDC42_HUMAN",1246,"P60953","CDC42_HUMAN","Cell division control protein 42 homolog",null,"CDC42"]
["23.3095","23.1761","23.7177","23.178",{"$nulls":3},"in utero embryonic development;liver development;negative regulation of neuron projection development;N-glycan processing;protein heterooligomerization;renal system development","calcium ion binding;RNA binding","endoplasmic reticulum",{"$nulls":3},16,16,11,"35.5","35.5","22.1","60.192",0,105,2312100000,93,"0.269604","0.757008","-0.205077","-0.737673","tr|K7ELL7|K7ELL7_HUMAN;sp|P14314|GLU2B_HUMAN;tr|K7EPW7|K7EPW7_HUMAN;tr|K7EKX1|K7EKX1_HUMAN;tr|K7EJ70|K7EJ70_HUMAN","tr|K7ELL7|K7ELL7_HUMAN;sp|P14314|GLU2B_HUMAN",3111,"K7ELL7","K7ELL7_HUMAN",null,null,"PRKCSH"]
["23.9457","24.0261","24.5246","23.8579",{"$nulls":3},"actin filament organization;movement of cell or subcellular component;muscle contraction;muscle filament sliding;osteoblast differentiation","actin filament binding;calcium ion binding;identical protein binding;protein heterodimerization activity;protein homodimerization activity;structural constituent of muscle","actin filament;cortical cytoskeleton;cytoskeleton;cytosol;extracellular exosome;filamentous actin;focal adhesion;membrane;muscle thin filament tropomyosin;podosome;stress fiber","Adrenergic signaling in cardiomyocytes;Cardiac muscle contraction;Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM)",null,null,13,9,6,"44.8","32.3","23.8","28.521",0,"313.21",2839100000,69,"0.219633","0.801555","-0.205342","-0.611588","sp|P67936|TPM4_HUMAN;tr|K7EMU5|K7EMU5_HUMAN;tr|K7EPV9|K7EPV9_HUMAN;tr|K7EPB9|K7EPB9_HUMAN;tr|K7EP68|K7EP68_HUMAN;tr|H0YL80|H0YL80_HUMAN","sp|P67936|TPM4_HUMAN",1354,"P67936","TPM4_HUMAN","Tropomyosin alpha-4 chain",null,"TPM4"]
["24.0464","23.9046","24.7507","23.6111",{"$nulls":3},"maturation of SSU-rRNA;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;ribosomal small subunit biogenesis;ribosome biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;nucleoplasm;small ribosomal subunit","Ribosome",null,null,2,2,2,"30.4","30.4","30.4","7.8409",0,"4.2712",598720000,8,"0.122185","0.902225","-0.2054","-0.35773","sp|P62857|RS28_HUMAN","sp|P62857|RS28_HUMAN",1323,"P62857","RS28_HUMAN","40S ribosomal protein S28",null,"RPS28"]
["21.5813","21.4152","21.7411","21.6678",{"$nulls":3},"membrane raft assembly;positive regulation of binding;positive regulation of focal adhesion assembly;positive regulation of GTPase activity;positive regulation of stress fiber assembly;positive regulation of substrate adhesion-dependent cell spreading;protein heterotetramerization;protein localization to plasma membrane;response to drug;vesicle budding from membrane","calcium ion binding;ion channel binding;protein homodimerization activity","endoplasmic reticulum;extracellular exosome;extracellular region;extrinsic component of plasma membrane",{"$nulls":3},1,1,1,"10.3","10.3","10.3","11.203","0.0034352","2.0796",105430000,9,"0.820743","0.321306","-0.20621","-2.27137","sp|P60903|S10AA_HUMAN","sp|P60903|S10AA_HUMAN",1245,"P60903","S10AA_HUMAN","Protein S100-A10",null,"S100A10"]
["22.4159","22.0615","22.4936","22.3989",{"$nulls":3},"cellular amino acid biosynthetic process;glutamate biosynthetic process;glutamate catabolic process;glutamine metabolic process;mitochondrion organization;positive regulation of insulin secretion;substantia nigra development;tricarboxylic acid metabolic process","ADP binding;ATP binding;glutamate dehydrogenase (NAD+) activity;glutamate dehydrogenase [NAD(P)+] activity;GTP binding;identical protein binding;leucine binding;NAD+ binding","cytoplasm;mitochondrial matrix;mitochondrion","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Carbon metabolism;D-Glutamine and D-glutamate metabolism;Metabolic pathways;Necroptosis;Nitrogen metabolism;Proximal tubule bicarbonate reclamation",null,null,9,9,9,"22.6","22.6","22.6","61.397",0,"21.464",1487400000,51,"0.425536","0.588041","-0.207506","-1.13117","sp|P00367|DHE3_HUMAN;sp|P49448|DHE4_HUMAN","sp|P00367|DHE3_HUMAN;sp|P49448|DHE4_HUMAN",463,"P00367","DHE3_HUMAN","Glutamate dehydrogenase 1, mitochondrial","DH 1","GLUD1"]
["22.3554","22.0936","22.6686","22.1962",{"$nulls":4},"cadherin binding","extracellular exosome;mitochondrion",{"$nulls":3},11,11,11,"47.6","47.6","47.6","34.793",0,"47.918",856020000,50,"0.282499","0.746651","-0.207965","-0.770034","sp|Q9HC38|GLOD4_HUMAN;tr|F6TLX2|F6TLX2_HUMAN;tr|I3L3Q4|I3L3Q4_HUMAN;tr|I3L1I0|I3L1I0_HUMAN","sp|Q9HC38|GLOD4_HUMAN;tr|F6TLX2|F6TLX2_HUMAN;tr|I3L3Q4|I3L3Q4_HUMAN",2641,"Q9HC38","GLOD4_HUMAN","Glyoxalase domain-containing protein 4",null,"GLOD4"]
["20.7447","20.455","21.1936","20.4243",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell division;ciliary basal body-plasma membrane docking;cytoplasmic microtubule organization;cytoplasmic mRNA processing body assembly;ER to Golgi vesicle-mediated transport;establishment of spindle localization;G2/M transition of mitotic cell cycle;minus-end-directed vesicle transport along microtubule;mitotic spindle organization;neutrophil degranulation;positive regulation of intracellular transport;positive regulation of spindle assembly;regulation of G2/M transition of mitotic cell cycle;regulation of metaphase plate congression;regulation of mitotic spindle organization;sister chromatid cohesion;stress granule assembly","ATP binding;ATPase activity;dynein intermediate chain binding;dynein light chain binding;dynein light intermediate chain binding;microtubule motor activity;RNA binding","azurophil granule lumen;centrosome;cytoplasmic dynein complex;cytosol;extracellular exosome;extracellular matrix;extracellular region;filopodium;membrane;microtubule","Phagosome;Salmonella infection;Vasopressin-regulated water reabsorption",null,null,92,92,92,"26.1","26.1","26.1","532.4",0,"323.31",5523700000,415,"0.179455","0.840651","-0.209081","-0.508706","sp|Q14204|DYHC1_HUMAN;tr|H0YJ21|H0YJ21_HUMAN","sp|Q14204|DYHC1_HUMAN",1612,"Q14204","DYHC1_HUMAN","Cytoplasmic dynein 1 heavy chain 1",null,"DYNC1H1"]
["19.8947","20.0962","20.0069","20.4025",{"$nulls":9},2,2,2,"23.2","23.2","23.2","15.898",0,"165.77",82237000,11,"0.351249","0.685631","-0.209239","-0.942561","tr|E5RJD2|E5RJD2_HUMAN;tr|E5RJG7|E5RJG7_HUMAN;tr|E5RFV2|E5RFV2_HUMAN;sp|Q16698|DECR_HUMAN","tr|E5RJD2|E5RJD2_HUMAN;tr|E5RJG7|E5RJG7_HUMAN;tr|E5RFV2|E5RFV2_HUMAN;sp|Q16698|DECR_HUMAN",1751,"E5RJD2","E5RJD2_HUMAN",null,null,"DECR1"]
["20.4175","20.0865","20.747","20.1756",{"$nulls":3},"ether lipid biosynthetic process;lipid biosynthetic process","alkylglycerone-phosphate synthase activity;FAD binding;oxidoreductase activity, acting on CH-OH group of donors","membrane;mitochondrion;nucleolus;peroxisomal matrix;peroxisomal membrane;peroxisome","Ether lipid metabolism;Metabolic pathways;Peroxisome",null,null,11,11,11,"23.7","23.7","23.7","72.911",0,"68.638",445800000,50,"0.228407","0.794305","-0.209267","-0.633841","sp|O00116|ADAS_HUMAN;tr|B8ZZ81|B8ZZ81_HUMAN","sp|O00116|ADAS_HUMAN",116,"O00116","ADAS_HUMAN","Alkyldihydroxyacetonephosphate synthase, peroxisomal","lkyl-DHAP synthase","AGPS"]
["22.9625","22.6117","23.4761","22.5168",{"$nulls":3},"signal transduction",{"$nulls":5},6,6,3,"31.5","31.5","19.4","25.538",0,"51.393",813900000,27,"0.141693","0.88431","-0.209327","-0.409896","tr|C9JIS1|C9JIS1_HUMAN;tr|C9JXA5|C9JXA5_HUMAN;sp|P62879|GBB2_HUMAN;tr|C9JZN1|C9JZN1_HUMAN;tr|E7EP32|E7EP32_HUMAN;sp|Q9HAV0|GBB4_HUMAN;tr|C9JD14|C9JD14_HUMAN","tr|C9JIS1|C9JIS1_HUMAN;tr|C9JXA5|C9JXA5_HUMAN;sp|P62879|GBB2_HUMAN;tr|C9JZN1|C9JZN1_HUMAN;tr|E7EP32|E7EP32_HUMAN;sp|Q9HAV0|GBB4_HUMAN",1327,"C9JIS1","C9JIS1_HUMAN",null,null,"GNB2"]
["20.5522","20.5619","20.8657","20.6676",{"$nulls":3},"activation of MAPK activity;basophil activation involved in immune response;diadenosine tetraphosphate biosynthetic process;ERK1 and ERK2 cascade;lysyl-tRNA aminoacylation;negative regulation of cell proliferation;positive regulation of cytokine production involved in inflammatory response;positive regulation of cytokine secretion involved in immune response;positive regulation of ERK1 and ERK2 cascade;positive regulation of macrophage activation;positive regulation of macrophage chemotaxis;positive regulation of metallopeptidase activity;positive regulation of p38MAPK cascade;positive regulation of transcription, DNA-templated;response to X-ray;tRNA aminoacylation for protein translation;tRNA processing;tumor necrosis factor-mediated signaling pathway;viral process","amino acid binding;ATP adenylyltransferase activity;ATP binding;identical protein binding;lysine-tRNA ligase activity;protein homodimerization activity;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytosol;extracellular space;mitochondrial matrix;mitochondrion;nucleus;plasma membrane","Aminoacyl-tRNA biosynthesis",null,null,9,9,9,"22.4","22.4","22.4","68.047",0,"28.182",524690000,46,"0.772469","0.337386","-0.209661","-2.11379","sp|Q15046|SYK_HUMAN;tr|H3BVA8|H3BVA8_HUMAN;tr|J3KRL2|J3KRL2_HUMAN;tr|H3BPV7|H3BPV7_HUMAN","sp|Q15046|SYK_HUMAN",1667,"Q15046","SYK_HUMAN","Lysine--tRNA ligase",null,"KARS"]
["21.8743","21.7528","22.3511","21.6967",{"$nulls":3},"cellular response to calcium ion;cellular response to epidermal growth factor stimulus;cellular response to platelet-derived growth factor stimulus;epidermal growth factor receptor signaling pathway;fibroblast growth factor receptor signaling pathway;glomerular visceral epithelial cell development;negative regulation of dephosphorylation;neuron projection extension;neutrophil degranulation;platelet-derived growth factor receptor signaling pathway;positive regulation of cellular protein localization;positive regulation of dendrite development;positive regulation of focal adhesion assembly;positive regulation of MAP kinase activity;positive regulation of peptidyl-tyrosine autophosphorylation;positive regulation of protein kinase activity;positive regulation of vascular associated smooth muscle cell migration;regulation of cytokine production;response to angiotensin;signal transduction","cadherin binding;calcium ion binding;calmodulin binding;GTPase activator activity;GTPase inhibitor activity;mitogen-activated protein kinase binding;phosphatidylinositol-3,4,5-trisphosphate binding;protein complex binding;protein domain specific binding;protein kinase binding;protein phosphatase binding;protein serine/threonine kinase activator activity;Rac GTPase binding;S100 protein binding","actin filament;axon;cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane;focal adhesion;growth cone;lateral plasma membrane;membrane raft;microtubule;midbody;neuron projection;nucleus;plasma membrane;protein complex;ruffle;secretory granule membrane;slit diaphragm","Adherens junction;Proteoglycans in cancer;Regulation of actin cytoskeleton",null,null,39,38,36,"36.5",36,"34.7","189.25",0,"313.74",3243500000,208,"0.227778","0.795266","-0.210408","-0.632246","sp|P46940|IQGA1_HUMAN;tr|H0YLE8|H0YLE8_HUMAN;tr|A0A0J9YXZ5|A0A0J9YXZ5_HUMAN;tr|A0A087WWP1|A0A087WWP1_HUMAN","sp|P46940|IQGA1_HUMAN;tr|H0YLE8|H0YLE8_HUMAN;tr|A0A0J9YXZ5|A0A0J9YXZ5_HUMAN",1041,"P46940","IQGA1_HUMAN","Ras GTPase-activating-like protein IQGAP1",null,"IQGAP1"]
["20.1619","19.9772","20.2851","20.2753",{"$nulls":3},"adipose tissue development;brain development;cellular ketone body metabolic process;heart development;ketone body catabolic process;ketone catabolic process;positive regulation of insulin secretion involved in cellular response to glucose stimulus;response to activity;response to drug;response to ethanol;response to hormone;response to nutrient;response to starvation","3-oxoacid CoA-transferase activity;protein homodimerization activity","mitochondrial matrix;mitochondrion;nucleoplasm","Butanoate metabolism;Metabolic pathways;Synthesis and degradation of ketone bodies;Valine, leucine and isoleucine degradation",null,null,5,5,5,"16.5","16.5","16.5","56.157",0,"141.27",268140000,34,"0.822558","0.3234","-0.210667","-2.27742","sp|P55809|SCOT1_HUMAN;tr|E9PDW2|E9PDW2_HUMAN","sp|P55809|SCOT1_HUMAN",1214,"P55809","SCOT1_HUMAN","Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial",null,"OXCT1"]
["19.805","19.702","20.3217","19.6073",{"$nulls":3},"cellular response to amino acid starvation;cellular response to amino acid stimulus;cellular response to leucine;cellular response to leucine starvation;glutaminyl-tRNA aminoacylation;leucyl-tRNA aminoacylation;negative regulation of autophagy;positive regulation of GTPase activity;positive regulation of TORC1 signaling;protein targeting to lysosome;regulation of cell size;tRNA aminoacylation for protein translation;valyl-tRNA aminoacylation","aminoacyl-tRNA editing activity;ATP binding;glutamine-tRNA ligase activity;GTPase activator activity;leucine-tRNA ligase activity;valine-tRNA ligase activity","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;endomembrane system;endoplasmic reticulum;lysosome;nuclear body","Aminoacyl-tRNA biosynthesis",null,null,12,12,12,"14.2","14.2","14.2","134.46",0,"56.053",573480000,50,"0.209017","0.814421","-0.21097","-0.584575","sp|Q9P2J5|SYLC_HUMAN;tr|A0A087WXY1|A0A087WXY1_HUMAN","sp|Q9P2J5|SYLC_HUMAN",2788,"Q9P2J5","SYLC_HUMAN","Leucine--tRNA ligase, cytoplasmic",null,"LARS"]
["23.1256","22.6772","23.0508","23.1748",{"$nulls":3},"chaperone-mediated protein folding;'de novo' protein folding;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization","ATP binding;protein binding involved in protein folding;RNA binding;unfolded protein binding;WD40-repeat domain binding","chaperonin-containing T-complex;cytoplasm;cytosol;extracellular exosome;extracellular matrix;microtubule",{"$nulls":3},18,18,13,"42.4","42.4","33.3","58.024",0,"237.07",2380800000,72,"0.337791","0.69909","-0.211364","-0.908718","sp|P40227|TCPZ_HUMAN;tr|J3KRI6|J3KRI6_HUMAN","sp|P40227|TCPZ_HUMAN",969,"P40227","TCPZ_HUMAN","T-complex protein 1 subunit zeta","CP-1-zeta","CCT6A"]
["23.6129","23.5179","24.0429","23.511",{"$nulls":3},"DNA replication;mitochondrion morphogenesis;mitochondrion organization;positive regulation of helicase activity","chromatin binding;RNA binding;single-stranded DNA binding","extracellular exosome;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleus","DNA replication;Homologous recombination;Mismatch repair",null,null,5,5,5,"43.2","43.2","43.2","17.259",0,"69.748",850680000,36,"0.287696","0.74374","-0.211541","-0.783069","sp|Q04837|SSBP_HUMAN;tr|C9K0U8|C9K0U8_HUMAN;tr|A0A0G2JLD8|A0A0G2JLD8_HUMAN;tr|E7EUY5|E7EUY5_HUMAN","sp|Q04837|SSBP_HUMAN;tr|C9K0U8|C9K0U8_HUMAN;tr|A0A0G2JLD8|A0A0G2JLD8_HUMAN;tr|E7EUY5|E7EUY5_HUMAN",1447,"Q04837","SSBP_HUMAN","Single-stranded DNA-binding protein, mitochondrial","tSSB;t-SSB","SSBP1"]
["19.6522","19.9025","20.5534","19.4244",{"$nulls":4},"aminopeptidase activity;metallopeptidase activity;zinc ion binding","cytosol",{"$nulls":3},4,4,4,"17.1","17.1","17.1","44.992",0,"9.1097",165150000,14,"0.125205","0.899721","-0.211545","-0.365864","tr|E7EMB6|E7EMB6_HUMAN;sp|Q9ULA0|DNPEP_HUMAN;tr|E7ETB3|E7ETB3_HUMAN;tr|F8WAN0|F8WAN0_HUMAN;tr|C9J1E2|C9J1E2_HUMAN;tr|B9ZVU2|B9ZVU2_HUMAN;tr|C9JBE1|C9JBE1_HUMAN","tr|E7EMB6|E7EMB6_HUMAN;sp|Q9ULA0|DNPEP_HUMAN;tr|E7ETB3|E7ETB3_HUMAN;tr|F8WAN0|F8WAN0_HUMAN",2887,"E7EMB6","E7EMB6_HUMAN",null,null,"DNPEP"]
["15.6634","15.7434","16.6368","15.1931",{"$nulls":3},"cell cycle G2/M phase transition;cellular response to lipopolysaccharide;cellular response to prostaglandin E stimulus;innate immune response;mitotic cell cycle;mitotic chromosome condensation;negative regulation of tumor necrosis factor production;positive regulation of histone deacetylation;protein transport;regulation of histone phosphorylation;regulation of transcription, DNA-templated;signal transduction;transcription, DNA-templated","double-stranded DNA binding;histone deacetylase binding;NF-kappaB binding;protein kinase A regulatory subunit binding;RNA binding;zinc ion binding","condensed chromosome;female pronucleus;Golgi apparatus;membrane;mitochondrion;nuclear matrix;nucleolus;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"2.9","2.9","2.9","76.107",0,"3.7869",11734000,4,"0.0983383","0.91755","-0.211551","-0.292628","sp|O43823|AKAP8_HUMAN","sp|O43823|AKAP8_HUMAN",270,"O43823","AKAP8_HUMAN","A-kinase anchor protein 8","KAP-8","AKAP8"]
["19.5206","19.4194","20.0096","19.3543",{"$nulls":3},"chromosome segregation;positive regulation of protein dephosphorylation","enzyme regulator activity;protein phosphatase regulator activity","chromosome;cytoplasm;extracellular exosome;nucleus",{"$nulls":3},6,6,6,"25.6","25.6","25.6","41.564",0,"58.075",178350000,23,"0.230602","0.792563","-0.211984","-0.639398","sp|Q15435|PP1R7_HUMAN;tr|B5MBZ8|B5MBZ8_HUMAN;tr|C9JD73|C9JD73_HUMAN;tr|C9J177|C9J177_HUMAN;tr|H7C003|H7C003_HUMAN;tr|C9JRC4|C9JRC4_HUMAN","sp|Q15435|PP1R7_HUMAN;tr|B5MBZ8|B5MBZ8_HUMAN;tr|C9JD73|C9JD73_HUMAN;tr|C9J177|C9J177_HUMAN;tr|H7C003|H7C003_HUMAN",1703,"Q15435","PP1R7_HUMAN","Protein phosphatase 1 regulatory subunit 7",null,"PPP1R7"]
["26.3462","26.2039","26.875","26.1009",{"$nulls":9},4,4,1,"46.2","46.2","9.7","10.469",0,"88.461",4944800000,87,"0.192038","0.830439","-0.212953","-0.54113","tr|J3QS39|J3QS39_HUMAN;tr|J3QTR3|J3QTR3_HUMAN;tr|F5H6Q2|F5H6Q2_HUMAN;sp|P62987|RL40_HUMAN;tr|F5GYU3|F5GYU3_HUMAN;tr|F5H2Z3|F5H2Z3_HUMAN;tr|F5H265|F5H265_HUMAN;tr|B4DV12|B4DV12_HUMAN;tr|F5H388|F5H388_HUMAN;sp|P62979|RS27A_HUMAN;tr|F5H747|F5H747_HUMAN;tr|F5GXK7|F5GXK7_HUMAN;tr|J3QKN0|J3QKN0_HUMAN;tr|Q5PY61|Q5PY61_HUMAN;sp|P0CG47|UBB_HUMAN;tr|Q96C32|Q96C32_HUMAN;sp|P0CG48|UBC_HUMAN;tr|M0R1V7|M0R1V7_HUMAN;tr|M0R1M6|M0R1M6_HUMAN;tr|M0R2S1|M0R2S1_HUMAN;tr|J3QSA3|J3QSA3_HUMAN;tr|K7EMA8|K7EMA8_HUMAN;tr|F5GZ39|F5GZ39_HUMAN","tr|J3QS39|J3QS39_HUMAN;tr|J3QTR3|J3QTR3_HUMAN;tr|F5H6Q2|F5H6Q2_HUMAN;sp|P62987|RL40_HUMAN;tr|F5GYU3|F5GYU3_HUMAN;tr|F5H2Z3|F5H2Z3_HUMAN;tr|F5H265|F5H265_HUMAN;tr|B4DV12|B4DV12_HUMAN;tr|F5H388|F5H388_HUMAN;sp|P62979|RS27A_HUMAN;tr|F5H747|F5H747_HUMAN;tr|F5GXK7|F5GXK7_HUMAN;tr|J3QKN0|J3QKN0_HUMAN;tr|Q5PY61|Q5PY61_HUMAN;sp|P0CG47|UBB_HUMAN;tr|Q96C32|Q96C32_HUMAN;sp|P0CG48|UBC_HUMAN;tr|M0R1V7|M0R1V7_HUMAN;tr|M0R1M6|M0R1M6_HUMAN;tr|M0R2S1|M0R2S1_HUMAN;tr|J3QSA3|J3QSA3_HUMAN;tr|K7EMA8|K7EMA8_HUMAN;tr|F5GZ39|F5GZ39_HUMAN",601,"J3QS39","J3QS39_HUMAN",null,null,"UBB"]
["23.9206","23.7736","24.149","23.972",{"$nulls":3},"IRE1-mediated unfolded protein response;posttranslational protein targeting to membrane, translocation;protein import into nucleus, translocation;retrograde protein transport, ER to cytosol;SRP-dependent cotranslational protein targeting to membrane, translocation;ubiquitin-dependent ERAD pathway","ARF guanyl-nucleotide exchange factor activity;epidermal growth factor binding;RNA binding","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum Sec complex;integral component of membrane;membrane;Sec61 translocon complex","Phagosome;Protein export;Protein processing in endoplasmic reticulum;Vibrio cholerae infection",null,null,3,3,3,"37.5","37.5","37.5","9.9743",0,"94.821",851710000,20,"0.68884","0.373895","-0.21336","-1.85519","sp|P60468|SC61B_HUMAN;tr|S4R3B5|S4R3B5_HUMAN","sp|P60468|SC61B_HUMAN",1236,"P60468","SC61B_HUMAN","Protein transport protein Sec61 subunit beta",null,"SEC61B"]
["19.9614","19.6677","20.502","19.5549",{"$nulls":3},"metabolic process","catalytic activity","cytoplasm;extracellular exosome;peroxisome",{"$nulls":3},4,4,4,"15.8","15.8","15.8","32.236",0,"4.0965",133850000,10,"0.149829","0.875863","-0.213891","-0.431405","sp|Q96CN7|ISOC1_HUMAN;tr|D6RGE2|D6RGE2_HUMAN","sp|Q96CN7|ISOC1_HUMAN;tr|D6RGE2|D6RGE2_HUMAN",2248,"Q96CN7","ISOC1_HUMAN","Isochorismatase domain-containing protein 1",null,"ISOC1"]
["22.3414","22.1838","22.6143","22.3388",{"$nulls":3},"actin cytoskeleton organization;cellular response to interferon-gamma;cytoskeletal anchoring at plasma membrane;epithelial cell morphogenesis;keratinocyte development;signal transduction;skeletal muscle tissue development","actin binding;cadherin binding;identical protein binding;RNA binding","actin cytoskeleton;brush border;cell cortex;cytoplasm;cytosol;extracellular exosome;extracellular matrix;focal adhesion;integral component of membrane;phagocytic vesicle;plasma membrane;stress fiber;Z disc","Focal adhesion;MAPK signaling pathway;Proteoglycans in cancer;Salmonella infection",null,null,88,79,76,"50.4","47.6","45.9","278.16",0,"323.31",7943000000,404,"0.508642","0.515021","-0.21393","-1.34816","sp|O75369|FLNB_HUMAN;tr|E7EN95|E7EN95_HUMAN;tr|H7C5L4|H7C5L4_HUMAN;tr|A0A0A0MT44|A0A0A0MT44_HUMAN;tr|A0A0C4DGA1|A0A0C4DGA1_HUMAN","sp|O75369|FLNB_HUMAN;tr|E7EN95|E7EN95_HUMAN",335,"O75369","FLNB_HUMAN","Filamin-B","LN-B","FLNB"]
["18.7288","18.7026","19.3919","18.4689",{"$nulls":3},"lipid metabolic process",null,"lysosome",{"$nulls":3},4,4,4,"11.9","11.9","11.9","41.796",0,"23.492",78172000,4,"0.162697","0.863105","-0.214762","-0.465164","tr|E7EMM4|E7EMM4_HUMAN;sp|Q13510|ASAH1_HUMAN","tr|E7EMM4|E7EMM4_HUMAN;sp|Q13510|ASAH1_HUMAN",1566,"E7EMM4","E7EMM4_HUMAN",null,null,"ASAH1"]
["17.9485","17.6977","18.3365","17.7398",{"$nulls":9},1,1,1,"5.3","5.3","5.3","32.468",0,"4.208",38803000,8,"0.240459","0.785409","-0.214994","-0.664311","tr|E7ENC1|E7ENC1_HUMAN;tr|F8WBI9|F8WBI9_HUMAN;tr|E9PEC3|E9PEC3_HUMAN;tr|E7ETT4|E7ETT4_HUMAN;tr|E7EUY3|E7EUY3_HUMAN;tr|E7ETT1|E7ETT1_HUMAN;sp|P05166|PCCB_HUMAN;tr|E9PDR0|E9PDR0_HUMAN;tr|C9JQS9|C9JQS9_HUMAN;tr|E7EX59|E7EX59_HUMAN","tr|E7ENC1|E7ENC1_HUMAN;tr|F8WBI9|F8WBI9_HUMAN;tr|E9PEC3|E9PEC3_HUMAN;tr|E7ETT4|E7ETT4_HUMAN;tr|E7EUY3|E7EUY3_HUMAN;tr|E7ETT1|E7ETT1_HUMAN;sp|P05166|PCCB_HUMAN;tr|E9PDR0|E9PDR0_HUMAN;tr|C9JQS9|C9JQS9_HUMAN;tr|E7EX59|E7EX59_HUMAN",516,"E7ENC1","E7ENC1_HUMAN",null,null,"PCCB"]
["21.3032","21.5093","22.461","20.7819",{"$nulls":3},"chromatin organization;establishment of protein localization to chromatin;negative regulation of transcription from RNA polymerase II promoter;nucleosome assembly;positive regulation of cell growth;positive regulation of histone H3-K9 methylation;protein stabilization","chromatin DNA binding;histone deacetylase binding;RNA binding","extracellular exosome;nuclear chromatin;nuclear heterochromatin;nucleosome;nucleus",{"$nulls":3},3,3,3,"17.3","17.3","17.3","22.58",0,"9.3871",202510000,7,"0.0846113","0.926126","-0.215157","-0.254363","sp|P16401|H15_HUMAN","sp|P16401|H15_HUMAN",696,"P16401","H15_HUMAN","Histone H1.5",null,"HIST1H1B"]
["21.3724","21.1891","21.8719","21.1213",{"$nulls":3},"cellular response to calcium ion;mRNA splicing, via spliceosome;regulation of transcription, DNA-templated","DNA binding;estrogen receptor binding;identical protein binding;ionotropic glutamate receptor binding;metal ion binding;myosin V binding;retinoid X receptor binding;RNA binding;thyroid hormone receptor binding;transcription coactivator activity","dendritic spine head;nucleoplasm;nucleus;perikaryon;perinuclear region of cytoplasm;polysome","Transcriptional misregulation in cancer",null,null,2,2,2,"4.9","4.9","4.9","53.425",0,"25.022",284690000,5,"0.198875","0.82189","-0.215823","-0.558662","sp|P35637|FUS_HUMAN;tr|H3BPE7|H3BPE7_HUMAN;tr|A0A075B7D9|A0A075B7D9_HUMAN;sp|Q92804|RBP56_HUMAN","sp|P35637|FUS_HUMAN;tr|H3BPE7|H3BPE7_HUMAN;tr|A0A075B7D9|A0A075B7D9_HUMAN;sp|Q92804|RBP56_HUMAN",937,"P35637","FUS_HUMAN","RNA-binding protein FUS",null,"FUS"]
["19.9272","20.5459","20.8672","20.0379",{"$nulls":3},"actin polymerization or depolymerization;axon guidance;cell junction assembly;neural tube closure;positive regulation of actin filament polymerization;protein homotetramerization","actin binding;cadherin binding;profilin binding;SH3 domain binding","actin cytoskeleton;bicellular tight junction;cytosol;extracellular exosome;filopodium membrane;focal adhesion;lamellipodium membrane;plasma membrane","cGMP-PKG signaling pathway;Fc gamma R-mediated phagocytosis;Focal adhesion;Leukocyte transendothelial migration;Platelet activation;Rap1 signaling pathway;Tight junction",null,null,8,8,8,30,30,30,"39.829",0,"92.746",283830000,31,"0.144562","0.879603","-0.215986","-0.417495","sp|P50552|VASP_HUMAN;tr|K7ENL7|K7ENL7_HUMAN;tr|K7EM16|K7EM16_HUMAN;tr|K7ENR7|K7ENR7_HUMAN;tr|K7EQD0|K7EQD0_HUMAN","sp|P50552|VASP_HUMAN",1117,"P50552","VASP_HUMAN","Vasodilator-stimulated phosphoprotein","ASP","VASP"]
["20.1016","19.1549","20.1699","19.5191",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone",null,"mitochondrial respiratory chain complex I;mitochondrion",{"$nulls":3},2,2,2,"19.6","19.6","19.6","20.383",0,"4.6372",84163000,6,"0.12913","0.898501","-0.216208","-0.376403","tr|E9PH64|E9PH64_HUMAN;tr|E7EWZ0|E7EWZ0_HUMAN;sp|Q9Y6M9|NDUB9_HUMAN;tr|E9PF49|E9PF49_HUMAN","tr|E9PH64|E9PH64_HUMAN;tr|E7EWZ0|E7EWZ0_HUMAN;sp|Q9Y6M9|NDUB9_HUMAN;tr|E9PF49|E9PF49_HUMAN",3055,"E9PH64","E9PH64_HUMAN",null,null,"NDUFB9"]
["14.5479","14.1367","15.8965","13.2209",{"$nulls":3},"cellular protein metabolic process;intracellular protein transport;positive regulation of protein catabolic process;toxin transport;vesicle-mediated transport","ADP-ribosylation factor binding;protein heterodimerization activity","clathrin adaptor complex;early endosome membrane;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;membrane;nucleoplasm;protein complex","Lysosome",null,null,1,1,1,"4.7","4.7","4.7","70.383","0.0011042","2.6748",5613300,1,"0.051754","0.948865","-0.216408","-0.159887","sp|Q9UJY5|GGA1_HUMAN","sp|Q9UJY5|GGA1_HUMAN",2863,"Q9UJY5","GGA1_HUMAN","ADP-ribosylation factor-binding protein GGA1",null,"GGA1"]
["22.0893","21.8753","22.4728","21.9246",{"$nulls":3},"heme catabolic process;oxidation-reduction process","biliverdin reductase activity;zinc ion binding","cytosol;extracellular exosome","Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,6,6,6,"21.6","21.6","21.6","33.428",0,"64.157",812210000,21,"0.26877","0.75635","-0.216429","-0.735577","sp|P53004|BIEA_HUMAN;tr|C9J1E1|C9J1E1_HUMAN","sp|P53004|BIEA_HUMAN",1173,"P53004","BIEA_HUMAN","Biliverdin reductase A","VR A","BLVRA"]
["17.6134","17.5245","18.3137","17.2576",{"$nulls":3},"actin cytoskeleton reorganization;AV node cell to bundle of His cell communication;AV node cell-bundle of His cell adhesion involved in cell communication;cardiac muscle fiber development;cell-cell junction organization;defense response to virus;epithelial structure maintenance;gamma-delta T cell activation;germ cell migration;heart development;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;homotypic cell-cell adhesion;leukocyte migration;mitochondrion organization;neutrophil chemotaxis;regulation of AV node cell action potential;regulation of immune response;transepithelial transport","beta-catenin binding;cell adhesion molecule binding;cell adhesive protein binding involved in AV node cell-bundle of His cell communication;connexin binding;identical protein binding;integrin binding;PDZ domain binding;receptor binding;virus receptor activity","acrosomal vesicle;adherens junction;apicolateral plasma membrane;basolateral plasma membrane;bicellular tight junction;cell body;cell junction;cell-cell adherens junction;cell-cell junction;cytoplasm;extracellular region;extracellular space;filopodium;growth cone;integral component of plasma membrane;intercalated disc;membrane raft;neuromuscular junction;neuron projection;nucleoplasm;plasma membrane;protein complex","Viral myocarditis",null,null,2,2,2,"6.8","6.8","6.8","40.029",0,"3.8416",49295000,7,"0.141348","0.884034","-0.21671","-0.40898","sp|P78310|CXAR_HUMAN","sp|P78310|CXAR_HUMAN",1363,"P78310","CXAR_HUMAN","Coxsackievirus and adenovirus receptor","AR;CAR","CXADR"]
["18.0175","17.6813","18.7577","17.3749",{"$nulls":3},"actin filament bundle retrograde transport;axonogenesis;Cdc42 protein signal transduction;cytoplasmic actin-based contraction involved in cell motility;endoplasmic reticulum polarization;netrin-activated signaling pathway;neuron projection morphogenesis;positive regulation of axon extension;positive regulation of neuron migration;Ras protein signal transduction;regulation of establishment of cell polarity;substrate-dependent cell migration, cell extension","actin filament binding;cadherin binding;kinesin binding","axon;axonal growth cone;cell leading edge;cytoplasm;filopodium;growth cone;lamellipodium;microtubule;microtubule associated complex;microtubule cytoskeleton;perikaryon;perinuclear region of cytoplasm",{"$nulls":3},4,4,4,9,9,9,"71.639",0,"32.341",112420000,17,"0.102772","0.914176","-0.216923","-0.304858","sp|A0MZ66|SHOT1_HUMAN","sp|A0MZ66|SHOT1_HUMAN",95,"A0MZ66","SHOT1_HUMAN","Shootin-1 {ECO:0000312|HGNC:HGNC:29319}",null,"SHTN1"]
["19.9147","18.6114","19.7975","19.1628",{"$nulls":4},"phospholipid transporter activity","intracellular",{"$nulls":3},4,4,4,"15.1","15.1","15.1","31.581",0,"6.0466",161910000,8,"0.100815","0.91463","-0.21706","-0.299467","tr|A0A0A0MSW4|A0A0A0MSW4_HUMAN;sp|P48739|PIPNB_HUMAN;tr|B3KYB6|B3KYB6_HUMAN;tr|B3KYB7|B3KYB7_HUMAN","tr|A0A0A0MSW4|A0A0A0MSW4_HUMAN;sp|P48739|PIPNB_HUMAN;tr|B3KYB6|B3KYB6_HUMAN;tr|B3KYB7|B3KYB7_HUMAN",1062,"A0A0A0MSW4","A0A0A0MSW4_HUMAN",null,null,"PITPNB"]
["22.0685","21.89","22.2861","22.1067",{"$nulls":3},"cristae formation;inner mitochondrial membrane organization;mitochondrial fusion;negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","phosphatase binding;protein complex scaffold activity;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytoplasm;extracellular exosome;MICOS complex;mitochondrial inner membrane;mitochondrion;nucleus",{"$nulls":3},4,4,4,"18.1","18.1","18.1","26.152",0,"11.093",463540000,13,"0.641627","0.402486","-0.217148","-1.71638","sp|Q9NX63|MIC19_HUMAN;tr|C9JRZ6|C9JRZ6_HUMAN;tr|F8WAR4|F8WAR4_HUMAN","sp|Q9NX63|MIC19_HUMAN;tr|C9JRZ6|C9JRZ6_HUMAN;tr|F8WAR4|F8WAR4_HUMAN",2737,"Q9NX63","MIC19_HUMAN","MICOS complex subunit MIC19",null,"CHCHD3"]
["22.0767","21.7878","22.3889","21.9102",{"$nulls":3},"2-oxoglutarate metabolic process;aspartate biosynthetic process;aspartate catabolic process;aspartate metabolic process;cellular amino acid biosynthetic process;cellular response to insulin stimulus;fatty acid homeostasis;gluconeogenesis;glutamate catabolic process to 2-oxoglutarate;glutamate catabolic process to aspartate;glutamate metabolic process;glycerol biosynthetic process;Notch signaling pathway;oxaloacetate metabolic process;response to glucocorticoid","carboxylic acid binding;L-aspartate:2-oxoglutarate aminotransferase activity;L-cysteine:2-oxoglutarate aminotransferase activity;L-phenylalanine:2-oxoglutarate aminotransferase activity;phosphatidylserine decarboxylase activity;pyridoxal phosphate binding","axon terminus;cytoplasm;cytosol;extracellular exosome;lysosome;nucleoplasm;nucleus","2-Oxocarboxylic acid metabolism;Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Metabolic pathways;Phenylalanine metabolism;Phenylalanine, tyrosine and tryptophan biosynthesis;Tyrosine metabolism",null,null,15,15,15,"52.5","52.5","52.5","46.247",0,"78.481",1020200000,75,"0.285448","0.746021","-0.217325","-0.777432","sp|P17174|AATC_HUMAN","sp|P17174|AATC_HUMAN",705,"P17174","AATC_HUMAN","Aspartate aminotransferase, cytoplasmic","AspAT","GOT1"]
["17.4552","17.3287","17.7653","17.4538",{"$nulls":3},"neutrophil degranulation;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;viral process","calmodulin binding;ubiquitin-protein transferase activity;zinc ion binding","centrosome;cytosol;ficolin-1-rich granule membrane;integral component of membrane;membrane;nucleoplasm;plasma membrane;specific granule membrane;tertiary granule membrane","Human papillomavirus infection;Viral carcinogenesis",null,null,16,16,16,"4.9","4.9","4.9","573.83",0,"42.601",512390000,61,"0.488402","0.523812","-0.217633","-1.29456","sp|Q5T4S7|UBR4_HUMAN;tr|A0A0A0MSW0|A0A0A0MSW0_HUMAN;tr|X6RE05|X6RE05_HUMAN;tr|X6R960|X6R960_HUMAN;tr|Q5TBN9|Q5TBN9_HUMAN","sp|Q5T4S7|UBR4_HUMAN",1832,"Q5T4S7","UBR4_HUMAN","E3 ubiquitin-protein ligase UBR4",null,"UBR4"]
["20.2383","20.0336","20.6514","20.0563",{"$nulls":3},"bile acid biosynthetic process;positive regulation of growth of symbiont in host;sterol transport","oxysterol binding;phosphatidylinositol-4-phosphate binding;protein domain specific binding;sterol transporter activity","cell junction;cytoplasm;cytosol;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;membrane;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},8,8,8,"15.2","15.2","15.2","89.42",0,"30.136",473940000,30,"0.251623","0.772008","-0.217892","-0.692458","sp|P22059|OSBP1_HUMAN;tr|H0YCV6|H0YCV6_HUMAN;tr|H7C1R2|H7C1R2_HUMAN;tr|H7C368|H7C368_HUMAN;tr|H7C428|H7C428_HUMAN;tr|A0A0A0MSB4|A0A0A0MSB4_HUMAN;tr|Q6ZN50|Q6ZN50_HUMAN;sp|Q969R2|OSBP2_HUMAN","sp|P22059|OSBP1_HUMAN",760,"P22059","OSBP1_HUMAN","Oxysterol-binding protein 1 {ECO:0000305}",null,"OSBP"]
["21.7746","21.4658","21.9757","21.7022",{"$nulls":3},"cell redox homeostasis;protein folding;response to endoplasmic reticulum stress","disulfide oxidoreductase activity;protein disulfide isomerase activity","endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},2,2,2,"7.9","7.9","7.9","31.791",0,"21.196",353650000,9,"0.397913","0.623116","-0.218752","-1.06059","sp|Q9H3N1|TMX1_HUMAN;tr|G3V448|G3V448_HUMAN","sp|Q9H3N1|TMX1_HUMAN;tr|G3V448|G3V448_HUMAN",2588,"Q9H3N1","TMX1_HUMAN","Thioredoxin-related transmembrane protein 1",null,"TMX1"]
["18.1571","18.2613","18.7008","18.1563",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"21.9","21.9","21.9","18.244",0,"4.2264",22919000,11,"0.291084","0.739943","-0.219406","-0.791563","tr|H0YDX2|H0YDX2_HUMAN;sp|Q9NPA0|EMC7_HUMAN;tr|H0YDT8|H0YDT8_HUMAN","tr|H0YDX2|H0YDX2_HUMAN;sp|Q9NPA0|EMC7_HUMAN;tr|H0YDT8|H0YDT8_HUMAN",2658,"H0YDX2","H0YDX2_HUMAN",null,null,"EMC7"]
["18.3819","18.491","19.2096","18.1025",{"$nulls":3},"DNA repair;DNA strand renaturation;double-strand break repair via homologous recombination","annealing helicase activity;ATP binding;ATP-dependent 3'-5' DNA helicase activity;ATP-dependent DNA helicase activity;DNA binding;DNA helicase activity;four-way junction helicase activity","chromosome;cytoplasm;membrane;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"6.5","6.5","6.5","73.457",0,"6.546",145450000,12,"0.136004","0.893396","-0.219583","-0.394773","sp|P46063|RECQ1_HUMAN;tr|F5H2L2|F5H2L2_HUMAN;tr|F8WA66|F8WA66_HUMAN;tr|F8WD97|F8WD97_HUMAN;tr|F5H4P4|F5H4P4_HUMAN;tr|F5H3W0|F5H3W0_HUMAN","sp|P46063|RECQ1_HUMAN;tr|F5H2L2|F5H2L2_HUMAN;tr|F8WA66|F8WA66_HUMAN;tr|F8WD97|F8WD97_HUMAN",1021,"P46063","RECQ1_HUMAN","ATP-dependent DNA helicase Q1",null,"RECQL"]
["20.9084","20.8894","21.2977","20.9393",{"$nulls":3},"positive regulation of mRNA binding;positive regulation of translation;translational initiation","RNA binding;translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex","RNA transport",null,null,11,11,11,"16.6","16.6","16.6","105.34",0,"62.734",979390000,47,"0.461467","0.541542","-0.219633","-1.22402","sp|Q99613|EIF3C_HUMAN;sp|B5ME19|EIFCL_HUMAN;tr|H3BPE3|H3BPE3_HUMAN;tr|H3BTY8|H3BTY8_HUMAN;tr|H3BPE4|H3BPE4_HUMAN","sp|Q99613|EIF3C_HUMAN;sp|B5ME19|EIFCL_HUMAN",2387,"Q99613","EIF3C_HUMAN","Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}","IF3c {ECO:0000255|HAMAP-Rule:MF_03002}","EIF3C"]
["19.3031","19.3068","19.8093","19.2403",{"$nulls":3},"cysteinyl-tRNA aminoacylation","ATP binding;cysteine-tRNA ligase activity","cytosol",{"$nulls":3},6,6,6,"11.9","11.9","11.9","84.277",0,"70.413",255380000,24,"0.283511","0.745865","-0.219806","-0.772574","tr|B4DKY1|B4DKY1_HUMAN;sp|P49589|SYCC_HUMAN","tr|B4DKY1|B4DKY1_HUMAN;sp|P49589|SYCC_HUMAN",1081,"B4DKY1","B4DKY1_HUMAN",null,null,"CARS"]
["18.1995","18.2954","18.6573","18.2787",{"$nulls":5},"cytosol;focal adhesion",{"$nulls":3},3,3,3,"10.3","10.3","10.3","45.345",0,"14.257",74403000,10,"0.424916","0.589137","-0.220572","-1.12958","tr|C9JUT4|C9JUT4_HUMAN;sp|Q93052|LPP_HUMAN;tr|C9JXK9|C9JXK9_HUMAN;tr|A0A087WZF1|A0A087WZF1_HUMAN;tr|C9JE51|C9JE51_HUMAN;tr|C9J2R5|C9J2R5_HUMAN;tr|C9JIY7|C9JIY7_HUMAN;tr|C9JT42|C9JT42_HUMAN;tr|C9J3U9|C9J3U9_HUMAN;tr|C9J1K7|C9J1K7_HUMAN;tr|C9J5C8|C9J5C8_HUMAN;tr|C9J4E3|C9J4E3_HUMAN","tr|C9JUT4|C9JUT4_HUMAN;sp|Q93052|LPP_HUMAN;tr|C9JXK9|C9JXK9_HUMAN;tr|A0A087WZF1|A0A087WZF1_HUMAN",2216,"C9JUT4","C9JUT4_HUMAN"]
["18.3452","19.0192","18.9765","18.8304",{"$nulls":5},"bicellular tight junction;cell junction;cytosol;plasma membrane",{"$nulls":3},15,15,15,"13.8","13.8","13.8","187.85",0,"111.62",442820000,55,"0.231495","0.792447","-0.221257","-0.641658","tr|A0A087X0K9|A0A087X0K9_HUMAN;tr|G5E9E7|G5E9E7_HUMAN;sp|Q07157|ZO1_HUMAN;tr|G3V1L9|G3V1L9_HUMAN;tr|H0Y3R8|H0Y3R8_HUMAN;tr|H0YLT6|H0YLT6_HUMAN;tr|H0YKB1|H0YKB1_HUMAN","tr|A0A087X0K9|A0A087X0K9_HUMAN;tr|G5E9E7|G5E9E7_HUMAN;sp|Q07157|ZO1_HUMAN;tr|G3V1L9|G3V1L9_HUMAN",1465,"A0A087X0K9","A0A087X0K9_HUMAN",null,null,"TJP1"]
["22.5066","22.3788","22.7545","22.5754",{"$nulls":3},"actin cytoskeleton organization;barbed-end actin filament capping","actin binding","cytoplasm;F-actin capping protein complex",{"$nulls":3},8,8,8,"32.7","32.7","32.7","29.295",0,"29.679",954520000,39,"0.74295","0.342845","-0.2223","-2.02053","tr|B1AK87|B1AK87_HUMAN;sp|P47756|CAPZB_HUMAN;tr|B1AK88|B1AK88_HUMAN;tr|B1AK85|B1AK85_HUMAN","tr|B1AK87|B1AK87_HUMAN;sp|P47756|CAPZB_HUMAN;tr|B1AK88|B1AK88_HUMAN;tr|B1AK85|B1AK85_HUMAN",1045,"B1AK87","B1AK87_HUMAN"]
["19.1184","18.7174","19.238","19.0433",{"$nulls":3},"cellular response to DNA damage stimulus;negative regulation of cell growth;positive regulation of cell growth;positive regulation of signal transduction;regulation of protein stability","p53 binding;RNA binding","granular component;nucleolus;nucleoplasm",{"$nulls":3},7,7,7,"17.2","17.2","17.2","61.124",0,"47.362",129600000,28,"0.373846","0.651355","-0.222791","-0.99956","sp|Q9NXV6|CARF_HUMAN;tr|J3KNE1|J3KNE1_HUMAN;tr|D6RGD2|D6RGD2_HUMAN","sp|Q9NXV6|CARF_HUMAN",2742,"Q9NXV6","CARF_HUMAN","CDKN2A-interacting protein",null,"CDKN2AIP"]
["19.1089","19.0828","19.521","19.1195",{"$nulls":3},"tRNA threonylcarbamoyladenosine modification","metal ion binding;N(6)-L-threonylcarbamoyladenine synthase","cytoplasm;EKC/KEOPS complex;nuclear speck;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},3,3,3,"13.4","13.4","13.4","36.426",0,"4.9891",104890000,16,"0.419371","0.595152","-0.224379","-1.11536","sp|Q9NPF4|OSGEP_HUMAN;tr|G3V445|G3V445_HUMAN","sp|Q9NPF4|OSGEP_HUMAN;tr|G3V445|G3V445_HUMAN",2661,"Q9NPF4","OSGEP_HUMAN","Probable tRNA N6-adenosine threonylcarbamoyltransferase {ECO:0000255|HAMAP-Rule:MF_03180}",null,"OSGEP"]
["17.4594","17.7613","17.8979","17.7725",{"$nulls":3},"adherens junction organization;bundle of His cell-Purkinje myocyte adhesion involved in cell communication;cornification;desmosome organization;epidermis development;intermediate filament organization;keratinization;keratinocyte differentiation;neutrophil degranulation;peptide cross-linking;protein localization to adherens junction;regulation of heart rate by cardiac conduction;regulation of ventricular cardiac muscle cell action potential;ventricular compact myocardium morphogenesis;wound healing","cell adhesion molecule binding;cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;protein binding, bridging;protein kinase C binding;RNA binding;scaffold protein binding;structural constituent of cytoskeleton;structural molecule activity","basolateral plasma membrane;cornified envelope;desmosome;extracellular exosome;extracellular matrix;fascia adherens;ficolin-1-rich granule membrane;intercalated disc;intermediate filament;nucleus;plasma membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC)",null,null,12,12,12,"5.3","5.3","5.3","331.77",0,"47.33",329880000,53,"0.518927","0.508404","-0.224865","-1.37562","sp|P15924|DESP_HUMAN","sp|P15924|DESP_HUMAN",690,"P15924","DESP_HUMAN","Desmoplakin","P","DSP"]
["29.4377","29.5275","29.7745","29.6405",{"$nulls":3},"cell junction assembly;cellular response to interferon-gamma;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component;platelet aggregation;retina homeostasis;sarcomere organization;vascular endothelial growth factor receptor signaling pathway","ATP binding;identical protein binding;profilin binding;structural constituent of cytoskeleton;ubiquitin protein ligase binding","actin filament;blood microparticle;cytoskeleton;cytosol;dense body;extracellular exosome;extracellular matrix;extracellular space;filamentous actin;focal adhesion;membrane;myelin sheath;myofibril;nucleus;phagocytic vesicle;plasma membrane","Adherens junction;Apoptosis;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Dilated cardiomyopathy (DCM);Fluid shear stress and atherosclerosis;Focal adhesion;Hepatocellular carcinoma;Hippo signaling pathway;Hypertrophic cardiomyopathy (HCM);Influenza A;Leukocyte transendothelial migration;Oxytocin signaling pathway;Pathogenic Escherichia coli infection;Phagosome;Platelet activation;Proteoglycans in cancer;Rap1 signaling pathway;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis;Thermogenesis;Thyroid hormone signaling pathway;Tight junction;Vibrio cholerae infection;Viral myocarditis;Yersinia infection",null,null,23,23,1,"73.9","73.9","4.5","41.792",0,"323.31",163200000000000,1083,"0.966174","0.295054","-0.224933","-2.78913","sp|P63261|ACTG_HUMAN;tr|I3L3I0|I3L3I0_HUMAN;tr|I3L1U9|I3L1U9_HUMAN;tr|I3L4N8|I3L4N8_HUMAN;tr|K7EM38|K7EM38_HUMAN;tr|I3L3R2|I3L3R2_HUMAN;tr|J3KT65|J3KT65_HUMAN;tr|C9JUM1|C9JUM1_HUMAN;sp|Q562R1|ACTBL_HUMAN;sp|Q9BYX7|ACTBM_HUMAN;tr|F8WCH0|F8WCH0_HUMAN","sp|P63261|ACTG_HUMAN;tr|I3L3I0|I3L3I0_HUMAN;tr|I3L1U9|I3L1U9_HUMAN;tr|I3L4N8|I3L4N8_HUMAN",1349,"P63261","ACTG_HUMAN","Actin, cytoplasmic 2",null,"ACTG1"]
["22.1445","22.0098","22.6165","21.9893",{"$nulls":5},"integral component of membrane",{"$nulls":3},4,4,4,"17.9","17.9","17.9","28.549",0,"3.9967",361350000,13,"0.25618","0.768246","-0.225774","-0.703931","tr|E9PIE4|E9PIE4_HUMAN;sp|Q9Y6C9|MTCH2_HUMAN","tr|E9PIE4|E9PIE4_HUMAN;sp|Q9Y6C9|MTCH2_HUMAN",3091,"E9PIE4","E9PIE4_HUMAN",null,null,"MTCH2"]
["17.0915","17.5289","17.9006","17.1732",{"$nulls":3},"angiogenesis;cell differentiation;innate immune response;intracellular signal transduction;negative regulation of viral genome replication;nuclear speck organization;positive regulation of cell cycle;positive regulation of cell proliferation;positive regulation of gene expression;positive regulation of neuron apoptotic process;positive regulation of viral genome replication;protein phosphorylation;regulation of mRNA splicing, via spliceosome;RNA splicing;spliceosomal complex assembly","14-3-3 protein binding;ATP binding;magnesium ion binding;protein serine/threonine kinase activity;RNA binding","cytoplasm;cytosol;nucleolus;nucleoplasm;nucleus",{"$nulls":3},4,3,3,"9.7","8.4","8.4","77.526",0,"7.5042",47860000,12,"0.189315","0.830175","-0.226693","-0.53413","sp|P78362|SRPK2_HUMAN;tr|H7C2I2|H7C2I2_HUMAN;tr|H7C521|H7C521_HUMAN;tr|H7C5L6|H7C5L6_HUMAN;tr|A8MPP7|A8MPP7_HUMAN;tr|A8MPY5|A8MPY5_HUMAN;sp|Q9UPE1|SRPK3_HUMAN;tr|E7ETV6|E7ETV6_HUMAN","sp|P78362|SRPK2_HUMAN",1368,"P78362","SRPK2_HUMAN","SRSF protein kinase 2",null,"SRPK2"]
["20.734","20.5194","21.2246","20.4837",{"$nulls":3},"diphosphate metabolic process;regulation of mitochondrial membrane potential;tRNA aminoacylation for protein translation","inorganic diphosphatase activity;magnesium ion binding;protein serine/threonine phosphatase activity","extracellular exosome;mitochondrial matrix","Oxidative phosphorylation",null,null,3,3,3,"12.3","12.3","12.3","37.92",0,"20.029",350130000,13,"0.211028","0.812572","-0.227457","-0.5897","sp|Q9H2U2|IPYR2_HUMAN;tr|D6R967|D6R967_HUMAN;tr|H0Y9D8|H0Y9D8_HUMAN","sp|Q9H2U2|IPYR2_HUMAN;tr|D6R967|D6R967_HUMAN;tr|H0Y9D8|H0Y9D8_HUMAN",2582,"Q9H2U2","IPYR2_HUMAN","Inorganic pyrophosphatase 2, mitochondrial",null,"PPA2"]
["19.2786","18.7961","19.4485","19.0812",{"$nulls":4},"ATP binding","cytosol",{"$nulls":3},7,7,7,"11.9","11.9","11.9","82.091",0,"33.857",293420000,27,"0.274687","0.754863","-0.227489","-0.750433","tr|I3L0N3|I3L0N3_HUMAN;sp|P46459|NSF_HUMAN;tr|I3L0L3|I3L0L3_HUMAN;tr|I3L338|I3L338_HUMAN;tr|I3L4Q9|I3L4Q9_HUMAN","tr|I3L0N3|I3L0N3_HUMAN;sp|P46459|NSF_HUMAN",1028,"I3L0N3","I3L0N3_HUMAN",null,null,"NSF"]
["16.3455","16.4495","17.477","15.7758",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding","cytosol;nucleus",{"$nulls":3},3,3,3,"6.3","6.3","6.3","91.43",0,"28.602",29580000,10,"0.0896854","0.9216","-0.22888","-0.268581","tr|E7EWK3|E7EWK3_HUMAN;sp|Q9H2U1|DHX36_HUMAN;tr|A0A0G2JRP3|A0A0G2JRP3_HUMAN;tr|A0A0G2JQU7|A0A0G2JQU7_HUMAN","tr|E7EWK3|E7EWK3_HUMAN;sp|Q9H2U1|DHX36_HUMAN",2581,"E7EWK3","E7EWK3_HUMAN",null,null,"DHX36"]
["20.208","20.3193","20.8026","20.1824",{"$nulls":3},"negative regulation of angiogenesis;negative regulation of transcription from RNA polymerase II promoter;negative regulation of vascular endothelial growth factor production;selenocysteine metabolic process;selenocysteinyl-tRNA(Sec) biosynthetic process;seryl-tRNA aminoacylation;transcription, DNA-templated;translation;tRNA aminoacylation for protein translation;tRNA processing","ATP binding;core promoter sequence-specific DNA binding;protein homodimerization activity;RNA binding;selenocysteine-tRNA ligase activity;serine-tRNA ligase activity","cytoplasm;cytosol;extracellular exosome;nucleus","Aminoacyl-tRNA biosynthesis",null,null,10,10,10,"33.5","33.5","33.5","58.777",0,"144.69",358480000,58,"0.265149","0.755821","-0.228883","-0.72648","sp|P49591|SYSC_HUMAN;tr|Q5T5C7|Q5T5C7_HUMAN","sp|P49591|SYSC_HUMAN;tr|Q5T5C7|Q5T5C7_HUMAN",1082,"P49591","SYSC_HUMAN","Serine--tRNA ligase, cytoplasmic",null,"SARS"]
["22.4641","22.223","22.6346","22.511",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","enzyme regulator activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle;proteasome regulatory particle, base subcomplex;proteasome storage granule;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,21,21,21,"30.3","30.3","30.3","100.2",0,"279.54",3440300000,112,"0.63334","0.410376","-0.229253","-1.69249","sp|Q13200|PSMD2_HUMAN;tr|C9JPC0|C9JPC0_HUMAN;tr|H7C2Q3|H7C2Q3_HUMAN;tr|H7C1H2|H7C1H2_HUMAN;tr|F8WBS8|F8WBS8_HUMAN","sp|Q13200|PSMD2_HUMAN",1533,"Q13200","PSMD2_HUMAN","26S proteasome non-ATPase regulatory subunit 2",null,"PSMD2"]
["19.9356","19.5697","19.9465","20.0182",{"$nulls":3},"long-chain fatty acid metabolic process;medium-chain fatty acid metabolic process;mitochondrial respiratory chain complex I assembly","flavin adenine dinucleotide binding;long-chain-acyl-CoA dehydrogenase activity;medium-chain-acyl-CoA dehydrogenase activity","dendrite;mitochondrial inner membrane;mitochondrial membrane;mitochondrion;nucleus",{"$nulls":3},6,6,6,"12.1","12.1","12.1","68.76",0,"11.047",276550000,19,"0.464569","0.538291","-0.229711","-1.2321","sp|Q9H845|ACAD9_HUMAN;tr|H0Y8Z9|H0Y8Z9_HUMAN;tr|D6RCD8|D6RCD8_HUMAN","sp|Q9H845|ACAD9_HUMAN",2615,"Q9H845","ACAD9_HUMAN","Acyl-CoA dehydrogenase family member 9, mitochondrial","CAD-9","ACAD9"]
["14.4353","14.5615","15.0556","14.4018",{"$nulls":3},"cell adhesion","structural molecule activity","extracellular matrix",{"$nulls":3},1,1,1,"2.5","2.5","2.5","70.733","0.0037749","2.0664",11246000,4,"0.251382","0.771965","-0.230343","-0.691852","tr|H7BXV5|H7BXV5_HUMAN;sp|P39060|COIA1_HUMAN","tr|H7BXV5|H7BXV5_HUMAN;sp|P39060|COIA1_HUMAN",963,"H7BXV5","H7BXV5_HUMAN",null,null,"COL18A1"]
["16.1449","15.3534","16.5789","15.3818",{"$nulls":3},"cerebellar Purkinje cell layer morphogenesis;ubiquinone biosynthetic process","ATP binding;kinase activity","cytosol;integral component of membrane;mitochondrial membrane;mitochondrion;plasma membrane",{"$nulls":3},2,2,2,"6.4","6.4","6.4","60.069",0,"6.5403",17632000,8,"0.109117","0.910325","-0.231231","-0.322255","sp|Q96D53|ADCK4_HUMAN;tr|M0R362|M0R362_HUMAN;tr|M0QZZ2|M0QZZ2_HUMAN;tr|M0R3F7|M0R3F7_HUMAN;tr|M0R001|M0R001_HUMAN;tr|M0R011|M0R011_HUMAN","sp|Q96D53|ADCK4_HUMAN;tr|M0R362|M0R362_HUMAN;tr|M0QZZ2|M0QZZ2_HUMAN;tr|M0R3F7|M0R3F7_HUMAN;tr|M0R001|M0R001_HUMAN;tr|M0R011|M0R011_HUMAN",2255,"Q96D53","COQ8B_HUMAN","Atypical kinase COQ8B, mitochondrial {ECO:0000305}",null,"COQ8B"]
["21.4629","21.2606","21.854","21.3323",{"$nulls":3},"protein transport",null,"endoplasmic reticulum;integral component of endoplasmic reticulum membrane",{"$nulls":3},34,34,33,"31.1","31.1","30.4","152.45",0,"323.31",2680200000,178,"0.305193","0.723777","-0.231374","-0.826933","tr|A0A0A0MRV0|A0A0A0MRV0_HUMAN;sp|Q9P2E9|RRBP1_HUMAN;tr|A0A087WVV2|A0A087WVV2_HUMAN;tr|F8W7S5|F8W7S5_HUMAN;tr|A0A087WU26|A0A087WU26_HUMAN;tr|A2A2S5|A2A2S5_HUMAN;tr|V9GY78|V9GY78_HUMAN;REV__sp|Q9P2M7|CING_HUMAN;tr|E9PN67|E9PN67_HUMAN","tr|A0A0A0MRV0|A0A0A0MRV0_HUMAN;sp|Q9P2E9|RRBP1_HUMAN;tr|A0A087WVV2|A0A087WVV2_HUMAN;tr|F8W7S5|F8W7S5_HUMAN",2787,"A0A0A0MRV0","A0A0A0MRV0_HUMAN",null,null,"RRBP1"]
["20.5599","20.291","20.9166","20.3973",{"$nulls":3},"ubiquitin-dependent ERAD pathway","ubiquitin protein ligase binding","cytosol;endoplasmic reticulum;plasma membrane",{"$nulls":3},5,5,3,21,21,"13.9","37.725",0,"14.105",284790000,27,"0.291112","0.740043","-0.23147","-0.791633","tr|E5RHW4|E5RHW4_HUMAN;sp|O94905|ERLN2_HUMAN;tr|E5RJ09|E5RJ09_HUMAN;tr|B0QZ43|B0QZ43_HUMAN","tr|E5RHW4|E5RHW4_HUMAN;sp|O94905|ERLN2_HUMAN",399,"E5RHW4","E5RHW4_HUMAN",null,null,"ERLIN2"]
["18.4416","18.3745","19.4548","17.8244",{"$nulls":3},"positive regulation of proteasomal ubiquitin-dependent protein catabolic process;post-translational protein modification;protein ubiquitination;response to interferon-gamma;response to tumor necrosis factor;ubiquitin-dependent protein catabolic process",null,"cytosol;nucleus",{"$nulls":3},5,5,5,"11.5","11.5","11.5","70.537",0,"14.483",113500000,8,"0.0951718","0.919604","-0.231593","-0.283856","sp|Q9Y5A7|NUB1_HUMAN;tr|H3BM14|H3BM14_HUMAN;tr|H3BM74|H3BM74_HUMAN;tr|C9JRT6|C9JRT6_HUMAN;tr|F8WDB6|F8WDB6_HUMAN;tr|H7C5E1|H7C5E1_HUMAN;tr|C9J7X7|C9J7X7_HUMAN;tr|H7C5N1|H7C5N1_HUMAN","sp|Q9Y5A7|NUB1_HUMAN;tr|H3BM14|H3BM14_HUMAN;tr|H3BM74|H3BM74_HUMAN;tr|C9JRT6|C9JRT6_HUMAN;tr|F8WDB6|F8WDB6_HUMAN",3013,"Q9Y5A7","NUB1_HUMAN","NEDD8 ultimate buster 1",null,"NUB1"]
["21.4215","21.1271","21.5602","21.4517",{"$nulls":3},"angiogenesis;negative regulation of cell proliferation;negative regulation of protein kinase activity;negative regulation of protein phosphorylation;positive regulation of gene expression;positive regulation of protein complex assembly;regulation of angiogenesis;regulation of protein ADP-ribosylation;translation;tRNA aminoacylation for protein translation;tryptophanyl-tRNA aminoacylation","ATP binding;kinase inhibitor activity;protein domain specific binding;protein homodimerization activity;protein kinase binding;tryptophan-tRNA ligase activity","cytoplasm;cytosol;extracellular exosome;nucleus;protein complex","Aminoacyl-tRNA biosynthesis",null,null,10,10,10,"28.9","28.9","28.9","53.165",0,"155.32",639150000,55,"0.556409","0.470654","-0.231693","-1.47699","sp|P23381|SYWC_HUMAN;tr|G3V277|G3V277_HUMAN;tr|G3V3H8|G3V3H8_HUMAN;tr|G3V3Y5|G3V3Y5_HUMAN;tr|G3V2F2|G3V2F2_HUMAN;tr|G3V3R3|G3V3R3_HUMAN;tr|G3V4S4|G3V4S4_HUMAN;tr|G3V313|G3V313_HUMAN;tr|G3V339|G3V339_HUMAN;tr|G3V2C0|G3V2C0_HUMAN;tr|G3V4C7|G3V4C7_HUMAN;tr|G3V4N8|G3V4N8_HUMAN;tr|G3V5W1|G3V5W1_HUMAN;tr|G3V3S7|G3V3S7_HUMAN;tr|G3V3X0|G3V3X0_HUMAN;tr|G3V3P2|G3V3P2_HUMAN;tr|G3V227|G3V227_HUMAN;tr|H0YJP3|H0YJP3_HUMAN;tr|G3V423|G3V423_HUMAN;tr|G3V5U1|G3V5U1_HUMAN;tr|G3V456|G3V456_HUMAN","sp|P23381|SYWC_HUMAN",777,"P23381","SYWC_HUMAN","Tryptophan--tRNA ligase, cytoplasmic",null,"WARS"]
["17.7306","17.7896","18.6695","17.3147",{"$nulls":3},"cellular response to interferon-gamma;intracellular protein transport;regulation of macroautophagy;retrograde transport, endosome to Golgi","protein transporter activity","cytosol;early endosome;endosome;late endosome;phagocytic vesicle;retromer complex;retromer, cargo-selective complex","Endocytosis",null,null,3,2,2,"10.7","8.6","8.6","39.154",0,"11.044",56158000,11,"0.116426","0.90458","-0.231992","-0.342152","sp|Q4G0F5|VP26B_HUMAN;tr|A0A0D9SFQ6|A0A0D9SFQ6_HUMAN","sp|Q4G0F5|VP26B_HUMAN",1785,"Q4G0F5","VP26B_HUMAN","Vacuolar protein sorting-associated protein 26B",null,"VPS26B"]
[1,"18.2618","18.729",1,{"$nulls":3},"carbohydrate metabolic process",{"$nulls":5},1,1,1,"15.6","15.6","15.6","18.912",0,"6.6241",14017000,3,"0.00583633","0.988418","-0.233583","-0.0188797","tr|M0R0U3|M0R0U3_HUMAN;tr|M0R261|M0R261_HUMAN;sp|O95336|6PGL_HUMAN","tr|M0R0U3|M0R0U3_HUMAN;tr|M0R261|M0R261_HUMAN;sp|O95336|6PGL_HUMAN",426,"M0R0U3","M0R0U3_HUMAN",null,null,"PGLS"]
["19.7736","19.6396","20.3524","19.529",{"$nulls":3},"apoptotic process;axonal fasciculation;cardiac epithelial to mesenchymal transition;cerebral cortex radial glia guided migration;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network membrane organization;endoplasmic reticulum tubular network organization;negative regulation of axon extension;negative regulation of axonogenesis;negative regulation of cell growth;nuclear pore complex assembly;positive regulation of epithelial cell migration;positive regulation of ERBB3 signaling pathway;positive regulation of mammary gland epithelial cell proliferation;positive regulation of protein kinase B signaling;positive regulation of protein localization to endoplasmic reticulum;protein stabilization;regulation of apoptotic process;regulation of branching morphogenesis of a nerve;regulation of cell migration","cadherin binding;RNA binding;ubiquitin protein ligase binding","cell projection;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum tubular network;endoplasmic reticulum tubular network membrane;extracellular exosome;integral component of endoplasmic reticulum membrane;intracellular;neuronal cell body;nuclear envelope;plasma membrane;postsynaptic density","Alzheimer disease",null,null,6,6,6,"12.8","12.8","12.8","129.93",0,"83.846",505790000,48,"0.199921","0.821487","-0.234145","-0.561341","sp|Q9NQC3|RTN4_HUMAN;tr|F8W914|F8W914_HUMAN","sp|Q9NQC3|RTN4_HUMAN;tr|F8W914|F8W914_HUMAN",2668,"Q9NQC3","RTN4_HUMAN","Reticulon-4",null,"RTN4"]
["18.5783","18.3003","19.1994","18.1476",{"$nulls":3},"cytoplasmic sequestering of protein;maintenance of unfolded protein involved in ERAD pathway;tail-anchored membrane protein insertion into ER membrane","chaperone binding","BAT3 complex;cytoplasm;cytosol;nucleolus;nucleoplasm",{"$nulls":3},2,2,2,"8.6","8.6","8.6","36.504",0,"5.4705",75557000,6,"0.149518","0.875364","-0.234217","-0.430585","sp|Q7L5D6|GET4_HUMAN;tr|C9JPA8|C9JPA8_HUMAN;tr|C9JHN8|C9JHN8_HUMAN","sp|Q7L5D6|GET4_HUMAN;tr|C9JPA8|C9JPA8_HUMAN;tr|C9JHN8|C9JHN8_HUMAN",1934,"Q7L5D6","GET4_HUMAN","Golgi to ER traffic protein 4 homolog",null,"GET4"]
[1,"15.9462",1,"16.4166",{"$nulls":3},"transport",null,"endosome;endosome membrane;extracellular exosome;integral component of plasma membrane",{"$nulls":3},1,1,1,"2.6","2.6","2.6","75.775",0,"5.8579",12035000,4,"0.00677974","0.987753","-0.235212","-0.0219084","sp|Q99805|TM9S2_HUMAN","sp|Q99805|TM9S2_HUMAN",2397,"Q99805","TM9S2_HUMAN","Transmembrane 9 superfamily member 2",null,"TM9SF2"]
["22.1819","22.121","22.3857","22.3891",{"$nulls":3},"cell adhesion;cell-cell signaling;cell-matrix adhesion;cellular response to interferon-gamma;integrin-mediated signaling pathway;regulation of inflammatory response;signal transduction;stress fiber assembly;transforming growth factor beta receptor signaling pathway;viral process","metal ion binding;RNA binding","cell-cell adherens junction;cytosol;focal adhesion;integral component of plasma membrane;nucleus;phagocytic vesicle;plasma membrane;stress fiber","Focal adhesion",null,null,13,13,13,"41.6","41.6","41.6","61.277",0,"285.28",1387800000,91,"1.78682","0.365547","-0.235938","-7.72744","sp|Q15942|ZYX_HUMAN;tr|H0Y2Y8|H0Y2Y8_HUMAN;tr|H7C3D3|H7C3D3_HUMAN;tr|C9IZ41|C9IZ41_HUMAN;tr|C9JJK5|C9JJK5_HUMAN;tr|H7C3R3|H7C3R3_HUMAN","sp|Q15942|ZYX_HUMAN;tr|H0Y2Y8|H0Y2Y8_HUMAN",1730,"Q15942","ZYX_HUMAN","Zyxin",null,"ZYX"]
["19.3477","19.185","19.6601","19.3463",{"$nulls":3},"nitric oxide biosynthetic process;oxidation-reduction process;regulation of nitric-oxide synthase activity;tetrahydrobiopterin biosynthetic process","aldo-keto reductase (NADP) activity;NADP binding;sepiapterin reductase activity","cytosol;extracellular exosome;nucleoplasm","Folate biosynthesis;Metabolic pathways",null,null,3,3,3,"19.9","19.9","19.9","28.048",0,"13.458",83828000,18,"0.505731","0.515019","-0.236887","-1.34042","sp|P35270|SPRE_HUMAN","sp|P35270|SPRE_HUMAN",930,"P35270","SPRE_HUMAN","Sepiapterin reductase","PR","SPR"]
["18.843","18.3169","19.4471","18.1866",{"$nulls":3},"malate metabolic process;pyruvate metabolic process;regulation of NADP metabolic process","electron transfer activity;malate dehydrogenase (decarboxylating) (NAD+) activity;malate dehydrogenase (decarboxylating) (NADP+) activity;malic enzyme activity;metal ion binding;NAD binding;oxaloacetate decarboxylase activity","mitochondrial matrix;mitochondrion","Carbon metabolism;Pyruvate metabolism",null,null,4,4,4,"11.1","11.1","11.1","65.443",0,"14.871",108050000,11,"0.118185","0.903941","-0.236925","-0.346921","sp|P23368|MAOM_HUMAN","sp|P23368|MAOM_HUMAN",776,"P23368","MAOM_HUMAN","NAD-dependent malic enzyme, mitochondrial","AD-ME","ME2"]
["18.7909","18.6624","19.3708","18.5567",{"$nulls":3},"cellular amino acid metabolic process;collagen catabolic process;proteolysis","aminopeptidase activity;manganese ion binding;metallocarboxypeptidase activity;proline dipeptidase activity","extracellular exosome",{"$nulls":3},4,4,4,"11.8","11.8","11.8","54.548",0,"82.529",99210000,19,"0.205435","0.818057","-0.237121","-0.575436","sp|P12955|PEPD_HUMAN;tr|V9GYE4|V9GYE4_HUMAN","sp|P12955|PEPD_HUMAN",650,"P12955","PEPD_HUMAN","Xaa-Pro dipeptidase",{"$f":"-Pro dipeptidase","v":{"$error":"#NAME?"}},"PEPD"]
["18.0908","18.1849","18.6336","18.1168",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;signal transduction;translation","GTP binding;GTPase activity;translation elongation factor activity","cytosol;extracellular exosome;intracellular;membrane","Legionellosis;mRNA surveillance pathway",null,null,3,3,3,"8.8","8.8","8.8","75.472",0,"11.431",129470000,19,"0.335835","0.696599","-0.237383","-0.903803","sp|Q9Y450|HBS1L_HUMAN;tr|B7Z524|B7Z524_HUMAN;tr|H0YDX7|H0YDX7_HUMAN;tr|J3QT46|J3QT46_HUMAN;tr|E9PN23|E9PN23_HUMAN;tr|E9PS53|E9PS53_HUMAN;tr|G5E991|G5E991_HUMAN;tr|E9PMN1|E9PMN1_HUMAN;tr|H0YES5|H0YES5_HUMAN;tr|E9PLR4|E9PLR4_HUMAN;tr|E9PHZ9|E9PHZ9_HUMAN","sp|Q9Y450|HBS1L_HUMAN;tr|B7Z524|B7Z524_HUMAN;tr|H0YDX7|H0YDX7_HUMAN;tr|J3QT46|J3QT46_HUMAN",2991,"Q9Y450","HBS1L_HUMAN","HBS1-like protein",null,"HBS1L"]
["21.4846","21.2803","21.7363","21.5049",{"$nulls":3},"succinate metabolic process;succinyl-CoA metabolic process;tricarboxylic acid cycle","ATP binding;GDP binding;GTP binding;metal ion binding;protein heterodimerization activity;succinate-CoA ligase (GDP-forming) activity","mitochondrial matrix;mitochondrion;plasma membrane;succinate-CoA ligase complex (GDP-forming)","Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways;Propanoate metabolism",null,null,8,8,8,22,22,22,"46.51",0,"57.3",674400000,32,"0.580526","0.456474","-0.238186","-1.54341","sp|Q96I99|SUCB2_HUMAN;tr|E9PDQ8|E9PDQ8_HUMAN;tr|H0Y852|H0Y852_HUMAN","sp|Q96I99|SUCB2_HUMAN;tr|E9PDQ8|E9PDQ8_HUMAN",2296,"Q96I99","SUCB2_HUMAN","Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03221}",null,"SUCLG2"]
["22.2648","22.1656","22.8084","22.099",{"$nulls":3},"microtubule-based process;neuron migration;positive regulation of axon guidance","GTP binding;GTPase activity;protein heterodimerization activity;structural constituent of cytoskeleton","cytoplasm;microtubule;microtubule cytoskeleton;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,21,5,1,"65.2",22,"2.7","49.953",0,"59.597",1322700000,59,"0.241066","0.785422","-0.238466","-0.665844","sp|Q9BVA1|TBB2B_HUMAN","sp|Q9BVA1|TBB2B_HUMAN",2468,"Q9BVA1","TBB2B_HUMAN","Tubulin beta-2B chain",null,"TUBB2B"]
["19.0591","18.698","19.7103","18.5248",{"$nulls":3},"acyl-CoA metabolic process","thiolester hydrolase activity",{"$nulls":4},3,3,3,"10.6","10.6","10.6","43.733",0,"42.915",96181000,7,"0.132628","0.898043","-0.239034","-0.385765","tr|G3V4F2|G3V4F2_HUMAN;tr|A0A087X0W7|A0A087X0W7_HUMAN;sp|Q86TX2|ACOT1_HUMAN;tr|A0A087WT95|A0A087WT95_HUMAN;sp|P49753|ACOT2_HUMAN","tr|G3V4F2|G3V4F2_HUMAN;tr|A0A087X0W7|A0A087X0W7_HUMAN;sp|Q86TX2|ACOT1_HUMAN;tr|A0A087WT95|A0A087WT95_HUMAN;sp|P49753|ACOT2_HUMAN",1975,"G3V4F2","G3V4F2_HUMAN",null,null,"ACOT1"]
["21.4704","21.4419","21.8431","21.5491",{"$nulls":3},"actin cytoskeleton organization;adenylate cyclase-activating dopamine receptor signaling pathway;auditory receptor cell stereocilium organization;bile acid secretion;cellular phosphate ion homeostasis;establishment of epithelial cell apical/basal polarity;establishment of Golgi localization;gland morphogenesis;glutathione transport;microvillus assembly;negative regulation of catenin import into nucleus;negative regulation of cell migration;negative regulation of cell proliferation;negative regulation of ERK1 and ERK2 cascade;negative regulation of mitotic cell cycle;negative regulation of phosphatidylinositol 3-kinase signaling;negative regulation of platelet-derived growth factor receptor signaling pathway;negative regulation of protein kinase B signaling;negative regulation of sodium:proton antiporter activity;nuclear migration;phospholipase C-activating dopamine receptor signaling pathway;positive regulation of intrinsic apoptotic signaling pathway;protein complex assembly;protein localization to plasma membrane;regulation of cell shape;regulation of cell size;regulation of excretion;regulation of protein kinase activity;regulation of sodium:proton antiporter activity;renal absorption;renal phosphate ion absorption;renal sodium ion transport;sensory perception of sound;Wnt signaling pathway","beta-2 adrenergic receptor binding;beta-catenin binding;chloride channel regulator activity;dopamine receptor binding;growth factor receptor binding;myosin II binding;PDZ domain binding;phosphatase binding;protein complex binding;protein complex scaffold activity;protein self-association;receptor binding","actin cytoskeleton;apical plasma membrane;brush border membrane;cell periphery;cytoplasm;endomembrane system;extracellular exosome;filopodium;membrane;membrane raft;microvillus;microvillus membrane;perinuclear region of cytoplasm;ruffle;sperm midpiece;stereocilium tip;vesicle","Human papillomavirus infection;Parathyroid hormone synthesis, secretion and action;Tight junction",null,null,9,9,9,"40.5","40.5","40.5","38.868",0,"33.303",713000000,40,"0.609624","0.42843","-0.239947","-1.6249","sp|O14745|NHRF1_HUMAN;tr|J3QRP6|J3QRP6_HUMAN","sp|O14745|NHRF1_HUMAN;tr|J3QRP6|J3QRP6_HUMAN",170,"O14745","NHRF1_HUMAN","Na(+)/H(+) exchange regulatory cofactor NHE-RF1","HERF-1","SLC9A3R1"]
["20.3692","19.3057","21.0639","19.092",{"$nulls":3},"regulation of translational initiation","ribosome binding;translation initiation factor activity","eukaryotic translation initiation factor 3 complex",{"$nulls":3},2,2,2,"18.2","18.2","18.2","15.875",0,"4.9845",110810000,6,"0.0706133","0.934152","-0.240455","-0.214652","tr|K7ES31|K7ES31_HUMAN;tr|K7ERF1|K7ERF1_HUMAN;sp|Q9UBQ5|EIF3K_HUMAN","tr|K7ES31|K7ES31_HUMAN;tr|K7ERF1|K7ERF1_HUMAN;sp|Q9UBQ5|EIF3K_HUMAN",2807,"K7ES31","K7ES31_HUMAN",null,null,"EIF3K"]
["21.1433","20.5685","21.0812","21.1116",{"$nulls":3},"fatty acid elongation;long-chain fatty-acyl-CoA biosynthetic process;very long-chain fatty acid biosynthetic process","oxidoreductase activity;very-long-chain-acyl-CoA dehydrogenase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;nucleus","Biosynthesis of unsaturated fatty acids;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways",null,null,4,4,4,"12.3","12.3","12.3","36.034",0,"14.163",298830000,16,"0.308642","0.716939","-0.240499","-0.835578","sp|Q9NZ01|TECR_HUMAN;tr|M0R3C3|M0R3C3_HUMAN;tr|M0QXM3|M0QXM3_HUMAN","sp|Q9NZ01|TECR_HUMAN;tr|M0R3C3|M0R3C3_HUMAN",2753,"Q9NZ01","TECR_HUMAN","Very-long-chain enoyl-CoA reductase {ECO:0000305}",null,"TECR"]
["23.4059","23.2248","23.9045","23.2097",{"$nulls":3},"translation","structural constituent of ribosome","large ribosomal subunit",{"$nulls":3},4,4,4,"33.3","33.3","33.3","11.498",0,"7.1464",718250000,24,"0.244037","0.783958","-0.241757","-0.673341","tr|J3KTJ8|J3KTJ8_HUMAN;tr|J3QRI7|J3QRI7_HUMAN;tr|J3QQQ9|J3QQQ9_HUMAN;tr|J3QQV1|J3QQV1_HUMAN;tr|E5RIT6|E5RIT6_HUMAN;tr|J3QRC4|J3QRC4_HUMAN;sp|Q9UNX3|RL26L_HUMAN;sp|P61254|RL26_HUMAN;tr|E5RHH1|E5RHH1_HUMAN;tr|J3KSS0|J3KSS0_HUMAN;tr|J3KS10|J3KS10_HUMAN","tr|J3KTJ8|J3KTJ8_HUMAN;tr|J3QRI7|J3QRI7_HUMAN;tr|J3QQQ9|J3QQQ9_HUMAN;tr|J3QQV1|J3QQV1_HUMAN;tr|E5RIT6|E5RIT6_HUMAN;tr|J3QRC4|J3QRC4_HUMAN;sp|Q9UNX3|RL26L_HUMAN;sp|P61254|RL26_HUMAN;tr|E5RHH1|E5RHH1_HUMAN;tr|J3KSS0|J3KSS0_HUMAN",1267,"J3KTJ8","J3KTJ8_HUMAN",null,null,"RPL26"]
["23.5701","23.6896","24.242","23.502",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;aggresome assembly;ATP metabolic process;autophagosome maturation;autophagy;cellular response to DNA damage stimulus;DNA repair;double-strand break repair;endoplasmic reticulum stress-induced pre-emptive quality control;endoplasmic reticulum unfolded protein response;endosome to lysosome transport via multivesicular body sorting pathway;ER to Golgi vesicle-mediated transport;ERAD pathway;ER-associated misfolded protein catabolic process;error-free translesion synthesis;establishment of protein localization;flavin adenine dinucleotide catabolic process;macroautophagy;NADH metabolic process;neutrophil degranulation;positive regulation of ATP biosynthetic process;positive regulation of Lys63-specific deubiquitinase activity;positive regulation of mitochondrial membrane potential;positive regulation of oxidative phosphorylation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein catabolic process;positive regulation of protein complex assembly;positive regulation of protein K63-linked deubiquitination;proteasomal protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein folding;protein hexamerization;protein homooligomerization;protein methylation;protein N-linked glycosylation via asparagine;protein ubiquitination;regulation of aerobic respiration;regulation of apoptotic process;retrograde protein transport, ER to cytosol;translesion synthesis;transmembrane transport;ubiquitin-dependent ERAD pathway;viral genome replication","ADP binding;ATP binding;ATPase activity;BAT3 complex binding;deubiquitinase activator activity;identical protein binding;K48-linked polyubiquitin modification-dependent protein binding;lipid binding;MHC class I protein binding;polyubiquitin modification-dependent protein binding;protein domain specific binding;protein phosphatase binding;RNA binding;ubiquitin protein ligase binding;ubiquitin-like protein ligase binding;ubiquitin-specific protease binding","ATPase complex;azurophil granule lumen;cytoplasm;cytosol;Derlin-1 retrotranslocation complex;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular membrane-bounded organelle;lipid droplet;myelin sheath;nucleoplasm;nucleus;perinuclear region of cytoplasm;proteasome complex;protein complex;secretory granule lumen;site of double-strand break;VCP-NPL4-UFD1 AAA ATPase complex;VCP-NSFL1C complex","Legionellosis;Protein processing in endoplasmic reticulum",null,null,38,38,38,"59.8","59.8","59.8","89.321",0,"323.31",6819000000,226,"0.233295","0.792141","-0.242177","-0.646211","sp|P55072|TERA_HUMAN;tr|C9IZA5|C9IZA5_HUMAN;tr|C9JUP7|C9JUP7_HUMAN","sp|P55072|TERA_HUMAN",1205,"P55072","TERA_HUMAN","Transitional endoplasmic reticulum ATPase","ER ATPase","VCP"]
["14.0804","14.623","14.6672","14.5218",{"$nulls":3},"protein K48-linked deubiquitination","RNA binding;thiol-dependent ubiquitin-specific protease activity",{"$nulls":4},1,1,1,"1.1","1.1","1.1","124.04","0.00076628","2.9824",11058000,2,"0.320198","0.709658","-0.242819","-0.864557","sp|Q01804|OTUD4_HUMAN","sp|Q01804|OTUD4_HUMAN",1420,"Q01804","OTUD4_HUMAN","OTU domain-containing protein 4",null,"OTUD4"]
["19.3963","18.9658","19.4854","19.3624",{"$nulls":3},"B cell proliferation;CTP biosynthetic process;'de novo' CTP biosynthetic process;glutamine metabolic process;nucleobase-containing compound metabolic process;nucleobase-containing small molecule interconversion;response to drug;T cell proliferation","ATP binding;CTP synthase activity;identical protein binding","cytosol;membrane","Metabolic pathways;Pyrimidine metabolism",null,null,7,7,5,"21.2","21.2","16.8","66.69",0,"42.564",264820000,30,"0.407484","0.610728","-0.242874","-1.08498","sp|P17812|PYRG1_HUMAN","sp|P17812|PYRG1_HUMAN",711,"P17812","PYRG1_HUMAN","CTP synthase 1 {ECO:0000305}",null,"CTPS1"]
["15.915","15.7317","17.0862","15.0466",{"$nulls":3},"DNA replication;maintenance of mitotic sister chromatid cohesion;positive regulation of DNA-directed DNA polymerase activity;post-translational protein acetylation;regulation of DNA replication","DNA binding","chromatin;chromosome, centromeric region;Ctf18 RFC-like complex;nucleoplasm",{"$nulls":3},1,1,1,"2.8","2.8","2.8","44.825","0.005996","1.8599",14150000,3,"0.0785887","0.930583","-0.243044","-0.237368","sp|Q9BVC3|DCC1_HUMAN","sp|Q9BVC3|DCC1_HUMAN",2469,"Q9BVC3","DCC1_HUMAN","Sister chromatid cohesion protein DCC1",null,"DSCC1"]
["18.1413","18.2332","18.6003","18.263",{"$nulls":3},"myosin filament assembly;negative regulation of endoplasmic reticulum calcium ion concentration;positive regulation of GTPase activity;positive regulation of mitochondrial calcium ion concentration;small GTPase mediated signal transduction;vascular smooth muscle contraction","GTPase activator activity","cytosol;endoplasmic reticulum;extracellular exosome;mitochondrion",{"$nulls":3},1,1,1,2,2,2,"66.316",0,"20.269",96872000,9,"0.527323","0.498548","-0.24444","-1.39814","sp|P52306|GDS1_HUMAN","sp|P52306|GDS1_HUMAN",1156,"P52306","GDS1_HUMAN","Rap1 GTPase-GDP dissociation stimulator 1",null,"RAP1GDS1"]
["19.4922","19.07","19.8236","19.2278",{"$nulls":3},"cardiolipin biosynthetic process","phosphatidate cytidylyltransferase activity",{"$nulls":4},1,1,1,"29.1","29.1","29.1","6.2061","0.00039479","3.2901",27769000,9,"0.242712","0.784707","-0.244633","-0.669998","tr|H7C1A2|H7C1A2_HUMAN;tr|A0A0G2JQ92|A0A0G2JQ92_HUMAN;sp|Q96BW9|TAM41_HUMAN","tr|H7C1A2|H7C1A2_HUMAN;tr|A0A0G2JQ92|A0A0G2JQ92_HUMAN;sp|Q96BW9|TAM41_HUMAN",2240,"H7C1A2","H7C1A2_HUMAN",null,null,"TAMM41"]
["26.5389","26.6102","27.0911","26.5479",{"$nulls":3},"cell proliferation;cell redox homeostasis;cellular response to oxidative stress;erythrocyte homeostasis;hydrogen peroxide catabolic process;natural killer cell activation;natural killer cell mediated cytotoxicity;regulation of NF-kappaB import into nucleus;regulation of stress-activated MAPK cascade;removal of superoxide radicals;retina homeostasis;skeletal system development","cadherin binding;identical protein binding;peroxidase activity;RNA binding;thioredoxin peroxidase activity","cytoplasm;cytosol;extracellular exosome;extracellular matrix;extracellular space;melanosome;mitochondrion;myelin sheath;nucleus","Peroxisome",null,null,14,14,10,"60.8","60.8","42.7","22.11",0,"280.75",14642000000,109,"0.332019","0.703364","-0.244965","-0.89422","sp|Q06830|PRDX1_HUMAN;tr|A0A0A0MSI0|A0A0A0MSI0_HUMAN;tr|A0A0A0MRQ5|A0A0A0MRQ5_HUMAN","sp|Q06830|PRDX1_HUMAN;tr|A0A0A0MSI0|A0A0A0MSI0_HUMAN;tr|A0A0A0MRQ5|A0A0A0MRQ5_HUMAN",1461,"Q06830","PRDX1_HUMAN","Peroxiredoxin-1",null,"PRDX1"]
["15.9476","15.5664","16.626","15.3786",{"$nulls":3},"endosome organization;neutrophil degranulation;osteoblast differentiation;protein transport;receptor-mediated endocytosis;regulation of early endosome to late endosome transport;regulation of early endosome to recycling endosome transport",null,"azurophil granule membrane;cytosol;early endosome membrane;endosome membrane;extracellular exosome;intracellular membrane-bounded organelle;lysosomal membrane;membrane;plasma membrane;secretory granule membrane",{"$nulls":3},4,4,4,"2.9","2.9","2.9","254.41",0,"14.005",76435000,17,"0.129005","0.898544","-0.245264","-0.376068","sp|O75165|DJC13_HUMAN;tr|H0Y8Q2|H0Y8Q2_HUMAN","sp|O75165|DJC13_HUMAN",326,"O75165","DJC13_HUMAN","DnaJ homolog subfamily C member 13",null,"DNAJC13"]
["18.517","17.987","18.5018","18.493",{"$nulls":3},"translation","structural constituent of ribosome","mitochondrion;ribosome",{"$nulls":3},2,2,2,"14.4","14.4","14.4","29.485",0,"4.8372",61479000,13,"0.344628","0.689993","-0.245376","-0.925903","tr|H0Y4J2|H0Y4J2_HUMAN;tr|A6NHR2|A6NHR2_HUMAN;sp|Q9BZE1|RM37_HUMAN;tr|S4R369|S4R369_HUMAN","tr|H0Y4J2|H0Y4J2_HUMAN;tr|A6NHR2|A6NHR2_HUMAN;sp|Q9BZE1|RM37_HUMAN;tr|S4R369|S4R369_HUMAN",2516,"H0Y4J2","H0Y4J2_HUMAN",null,null,"MRPL37"]
["23.4077","23.2263","24.1953","22.9303",{"$nulls":3},"developmental growth;eukaryotic translation initiation factor 4F complex assembly;formation of translation preinitiation complex;regulation of translational initiation;sexual reproduction;translational initiation;viral process","cadherin binding;helicase activity;ribosomal small subunit binding;RNA binding;RNA strand annealing activity;RNA strand-exchange activity;translation factor activity, RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 4F complex;membrane;perinuclear region of cytoplasm;polysome",{"$nulls":3},7,7,7,"41.1","41.1","41.1","27.385",0,"47.498",1499000000,51,"0.132212","0.897753","-0.245783","-0.384652","sp|Q15056|IF4H_HUMAN","sp|Q15056|IF4H_HUMAN",1669,"Q15056","IF4H_HUMAN","Eukaryotic translation initiation factor 4H","IF-4H","EIF4H"]
["21.8389","21.6432","22.6373","21.3366",{"$nulls":4},"metal ion binding",{"$nulls":4},4,4,4,"35.6","35.6","35.6","16.94",0,"25.1",483580000,14,"0.128178","0.897333","-0.24587","-0.373852","tr|E9PP21|E9PP21_HUMAN;sp|P21291|CSRP1_HUMAN;tr|E9PND2|E9PND2_HUMAN;tr|E9PS42|E9PS42_HUMAN","tr|E9PP21|E9PP21_HUMAN;sp|P21291|CSRP1_HUMAN;tr|E9PND2|E9PND2_HUMAN;tr|E9PS42|E9PS42_HUMAN",753,"E9PP21","E9PP21_HUMAN",null,null,"CSRP1"]
["19.6046","18.52","19.0627","19.5536",{"$nulls":3},"calcium-mediated signaling;regulation of systemic arterial blood pressure;vesicle-mediated transport","actin binding;alpha-tubulin binding;calcium ion binding;clathrin binding;ligand-gated ion channel activity;tubulin binding","clathrin coat of trans-Golgi network vesicle;cytosol;extracellular exosome;intracellular","Olfactory transduction",null,null,2,2,2,"13.5","13.5","13.5","22.245",0,"10.516",74354000,13,"0.142888","0.883136","-0.245878","-0.413062","sp|P61601|NCALD_HUMAN;tr|E5RGA9|E5RGA9_HUMAN;tr|H7BZC1|H7BZC1_HUMAN;tr|E5RHC8|E5RHC8_HUMAN;tr|E5RIG4|E5RIG4_HUMAN;tr|E5RIZ1|E5RIZ1_HUMAN;tr|E5RIA5|E5RIA5_HUMAN;tr|E9PC71|E9PC71_HUMAN;sp|P84074|HPCA_HUMAN;sp|P37235|HPCL1_HUMAN","sp|P61601|NCALD_HUMAN;tr|E5RGA9|E5RGA9_HUMAN;tr|H7BZC1|H7BZC1_HUMAN;tr|E5RHC8|E5RHC8_HUMAN;tr|E5RIG4|E5RIG4_HUMAN;tr|E5RIZ1|E5RIZ1_HUMAN;tr|E5RIA5|E5RIA5_HUMAN;tr|E9PC71|E9PC71_HUMAN;sp|P84074|HPCA_HUMAN;sp|P37235|HPCL1_HUMAN",1275,"P61601","NCALD_HUMAN","Neurocalcin-delta",null,"NCALD"]
["16.1668","16.1094","16.8832","15.8848",{"$nulls":3},"axon guidance;microtubule cytoskeleton organization","hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds","cytosol",{"$nulls":3},5,2,2,"11.9","5.4","5.4","62.029","0.0011005","2.6396",21787000,3,"0.172942","0.849431","-0.245928","-0.491833","tr|E9PD68|E9PD68_HUMAN;sp|Q14194|DPYL1_HUMAN","tr|E9PD68|E9PD68_HUMAN;sp|Q14194|DPYL1_HUMAN",1610,"E9PD68","E9PD68_HUMAN",null,null,"CRMP1"]
["21.8777","21.5649","22.1239","21.8122",{"$nulls":3},"actin cytoskeleton organization;actin filament polymerization;anatomical structure morphogenesis;blood coagulation;bone resorption;cell adhesion;cell motility;cell proliferation;cell-matrix adhesion;cellular response to mechanical stimulus;ephrin receptor signaling pathway;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;G-protein coupled receptor signaling pathway;hepatocyte growth factor receptor signaling pathway;inflammatory response;intracellular signal transduction;lamellipodium assembly;localization within membrane;mast cell chemotaxis;movement of cell or subcellular component;negative regulation of interleukin-23 production;negative regulation of receptor-mediated endocytosis;neutrophil degranulation;platelet activation;positive regulation of apoptotic process;positive regulation of cell-substrate adhesion;positive regulation of DNA replication;positive regulation of focal adhesion assembly;positive regulation of lamellipodium assembly;positive regulation of microtubule polymerization;positive regulation of neutrophil chemotaxis;positive regulation of protein phosphorylation;positive regulation of Rho protein signal transduction;positive regulation of stress fiber assembly;positive regulation of substrate adhesion-dependent cell spreading;Rac protein signal transduction;regulation of cell migration;regulation of cell size;regulation of defense response to virus by virus;regulation of hydrogen peroxide metabolic process;regulation of lamellipodium assembly;regulation of respiratory burst;regulation of small GTPase mediated signal transduction;regulation of stress fiber assembly;response to wounding;ruffle organization;semaphorin-plexin signaling pathway;substrate adhesion-dependent cell spreading;T cell costimulation;vascular endothelial growth factor receptor signaling pathway;Wnt signaling pathway, planar cell polarity pathway","ATPase binding;enzyme binding;GTP binding;GTPase activity;histone deacetylase binding;protein kinase binding;protein serine/threonine kinase activity;Rab GTPase binding;Rho GDP-dissociation inhibitor binding;thioesterase binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;dendritic spine;endoplasmic reticulum membrane;extracellular exosome;extracellular matrix;ficolin-1-rich granule membrane;focal adhesion;Golgi membrane;lamellipodium;melanosome;membrane;plasma membrane;ruffle membrane;secretory granule membrane;trans-Golgi network","Adherens junction;AGE-RAGE signaling pathway in diabetic complications;Amyotrophic lateral sclerosis (ALS);Axon guidance;B cell receptor signaling pathway;Bacterial invasion of epithelial cells;cAMP signaling pathway;Chemokine signaling pathway;Choline metabolism in cancer;Colorectal cancer;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Osteoclast differentiation;Pancreatic cancer;Pancreatic secretion;Pathways in cancer;Phagosome;PI3K-Akt signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Salmonella infection;Shigellosis;Sphingolipid signaling pathway;Tight junction;Toll-like receptor signaling pathway;VEGF signaling pathway;Viral carcinogenesis;Viral myocarditis;Wnt signaling pathway;Yersinia infection",null,null,4,4,4,"27.6","27.6","27.6","21.45",0,"11.626",278010000,16,"0.420254","0.593985","-0.246764","-1.11762","sp|P63000|RAC1_HUMAN;tr|B1AH77|B1AH77_HUMAN;tr|B1AH78|B1AH78_HUMAN;tr|B1AH80|B1AH80_HUMAN;sp|P15153|RAC2_HUMAN;tr|J3KSC4|J3KSC4_HUMAN;tr|J3QLK0|J3QLK0_HUMAN;sp|P60763|RAC3_HUMAN","sp|P63000|RAC1_HUMAN;tr|B1AH77|B1AH77_HUMAN;tr|B1AH78|B1AH78_HUMAN;tr|B1AH80|B1AH80_HUMAN;sp|P15153|RAC2_HUMAN;tr|J3KSC4|J3KSC4_HUMAN;tr|J3QLK0|J3QLK0_HUMAN;sp|P60763|RAC3_HUMAN",1337,"P63000","RAC1_HUMAN","Ras-related C3 botulinum toxin substrate 1",null,"RAC1"]
["15.0337","14.5895","15.5922","14.5259",{"$nulls":3},"intracellular signal transduction;transmembrane transport",null,"integral component of membrane;intracellular",{"$nulls":3},1,1,1,"2.1","2.1","2.1","93.685","0.0010909","2.5403",6594100,1,"0.148717","0.876748","-0.247457","-0.428473","tr|A0A087WXK4|A0A087WXK4_HUMAN;sp|Q7Z3F1|GP155_HUMAN","tr|A0A087WXK4|A0A087WXK4_HUMAN;sp|Q7Z3F1|GP155_HUMAN",1948,"A0A087WXK4","A0A087WXK4_HUMAN",null,null,"GPR155"]
["18.011","18.1847","18.0929","18.5979",{"$nulls":3},"basement membrane assembly;cellular response to hormone stimulus;collagen fibril organization;collagen metabolic process;endothelial cell morphogenesis;epidermis morphogenesis;hydroxylysine biosynthetic process;in utero embryonic development;lung morphogenesis;neural tube development;peptidyl-lysine hydroxylation;protein localization;protein O-linked glycosylation;vasodilation","iron ion binding;L-ascorbic acid binding;procollagen galactosyltransferase activity;procollagen glucosyltransferase activity;procollagen-lysine 5-dioxygenase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;extracellular matrix;Golgi apparatus;rough endoplasmic reticulum membrane;trans-Golgi network","Lysine degradation;Other types of O-glycan biosynthesis",null,null,5,5,5,"7.9","7.9","7.9","84.784",0,"10.724",148510000,20,"0.345088","0.689776","-0.247531","-0.92706","sp|O60568|PLOD3_HUMAN;tr|H7C2S8|H7C2S8_HUMAN;tr|H7C2V1|H7C2V1_HUMAN;tr|H7C0B8|H7C0B8_HUMAN","sp|O60568|PLOD3_HUMAN;tr|H7C2S8|H7C2S8_HUMAN;tr|H7C2V1|H7C2V1_HUMAN",295,"O60568","PLOD3_HUMAN","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3",null,"PLOD3"]
["21.6223","21.7596","22.183","21.6954",{"$nulls":3},"actomyosin contractile ring assembly;apoptotic process;bicellular tight junction assembly;cell separation after cytokinesis;maintenance of epithelial cell apical/basal polarity;mitotic cytokinesis;multivesicular body assembly;positive regulation of exosomal secretion;positive regulation of extracellular exosome assembly;protein homooligomerization;protein transport;regulation of centrosome duplication;regulation of extracellular exosome assembly;regulation of membrane permeability;ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;viral budding;viral budding via host ESCRT complex;viral life cycle","calcium-dependent protein binding;protein homodimerization activity;proteinase activated receptor binding","actomyosin;bicellular tight junction;cytosol;endoplasmic reticulum exit site;extracellular exosome;extracellular vesicle;Flemming body;focal adhesion;immunological synapse;melanosome;membrane;microtubule organizing center;myelin sheath","Endocytosis",null,null,20,20,20,"35.1","35.1","35.1","96.022",0,"323.31",1762800000,131,"0.366306","0.663224","-0.24833","-0.980515","sp|Q8WUM4|PDC6I_HUMAN;tr|C9IZF9|C9IZF9_HUMAN;tr|F8WEQ7|F8WEQ7_HUMAN;tr|F8WBR8|F8WBR8_HUMAN;tr|F8WDK9|F8WDK9_HUMAN","sp|Q8WUM4|PDC6I_HUMAN",2141,"Q8WUM4","PDC6I_HUMAN","Programmed cell death 6-interacting protein","DCD6-interacting protein","PDCD6IP"]
[1,"19.0382","19.5356",1,{"$nulls":3},"nuclear envelope organization;regulation of intracellular signal transduction",null,"nuclear inner membrane",{"$nulls":3},1,1,1,"24.5","24.5","24.5","5.7934","0.0014099","2.3188",10498000,1,"0.0059458","0.989047","-0.248701","-0.0192314","tr|D6R958|D6R958_HUMAN;tr|H7C2Z0|H7C2Z0_HUMAN;sp|Q8NC56|LEMD2_HUMAN","tr|D6R958|D6R958_HUMAN;tr|H7C2Z0|H7C2Z0_HUMAN;sp|Q8NC56|LEMD2_HUMAN",2080,"D6R958","D6R958_HUMAN",null,null,"LEMD2"]
["18.4972","18.476","19.0273","18.4445",{"$nulls":3},"cellular response to drug;centrosome cycle;G2/M transition of mitotic cell cycle;mitotic cell cycle;negative regulation of catalytic activity;positive regulation of myosin-light-chain-phosphatase activity;positive regulation of transcription from RNA polymerase II promoter;protein dephosphorylation;regulation of cell adhesion;regulation of myosin-light-chain-phosphatase activity;regulation of nucleocytoplasmic transport","14-3-3 protein binding;enzyme inhibitor activity;phosphatase regulator activity;protein kinase binding;signal transducer activity","A band;actin cytoskeleton;centrosome;contractile fiber;cytosol;focal adhesion;kinetochore;nucleoplasm;PTW/PP1 phosphatase complex;Z disc","cAMP signaling pathway;cGMP-PKG signaling pathway;Focal adhesion;Oxytocin signaling pathway;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Vascular smooth muscle contraction",null,null,6,6,6,7,7,7,"115.28",0,"23.604",177850000,33,"0.316281","0.713333","-0.249229","-0.854731","sp|O14974|MYPT1_HUMAN;tr|H0YIS3|H0YIS3_HUMAN;tr|H0YHI8|H0YHI8_HUMAN;tr|F8VZN8|F8VZN8_HUMAN;tr|H0YIM2|H0YIM2_HUMAN;tr|H0YIS4|H0YIS4_HUMAN;tr|H0YIL7|H0YIL7_HUMAN","sp|O14974|MYPT1_HUMAN;tr|H0YIS3|H0YIS3_HUMAN;tr|H0YHI8|H0YHI8_HUMAN;tr|F8VZN8|F8VZN8_HUMAN",185,"O14974","MYPT1_HUMAN","Protein phosphatase 1 regulatory subunit 12A",null,"PPP1R12A"]
["17.1888","16.9014","17.5499","17.0409",{"$nulls":3},"mitochondrial asparaginyl-tRNA aminoacylation;tRNA aminoacylation;tRNA aminoacylation for protein translation","aspartate-tRNA ligase activity;aspartate-tRNA(Asn) ligase activity;ATP binding;protein homodimerization activity;tRNA binding","mitochondrial matrix;mitochondrion;nucleus","Aminoacyl-tRNA biosynthesis",null,null,3,3,3,"7.3","7.3","7.3","73.562",0,"8.5282",51507000,11,"0.316937","0.713923","-0.250314","-0.856376","sp|Q6PI48|SYDM_HUMAN","sp|Q6PI48|SYDM_HUMAN",1894,"Q6PI48","SYDM_HUMAN","Aspartate--tRNA ligase, mitochondrial",null,"DARS2"]
["23.6707","23.4569","24.19","23.4422",{"$nulls":3},"cellular response to DNA damage stimulus;protein ubiquitination;ubiquitin-dependent protein catabolic process","ATP binding;RNA binding;ubiquitin activating enzyme activity","cytoplasm;cytosol;extracellular exosome;mitochondrion;nucleoplasm;nucleus","Parkinson disease;Ubiquitin mediated proteolysis",null,null,38,38,38,"49.2","49.2","49.2","117.85",0,"323.31",7210700000,275,"0.234303","0.790357","-0.252308","-0.64876","sp|P22314|UBA1_HUMAN;tr|Q5JRR6|Q5JRR6_HUMAN;tr|Q5JRR9|Q5JRR9_HUMAN;tr|Q5JRS0|Q5JRS0_HUMAN;tr|Q5JRS2|Q5JRS2_HUMAN;tr|Q5JRS1|Q5JRS1_HUMAN;tr|Q5JRS3|Q5JRS3_HUMAN","sp|P22314|UBA1_HUMAN",765,"P22314","UBA1_HUMAN","Ubiquitin-like modifier-activating enzyme 1",null,"UBA1"]
["22.0577","21.979","22.6626","21.8795",{"$nulls":3},"gastrulation with mouth forming second;glycosaminoglycan biosynthetic process;UDP-glucose metabolic process;UDP-glucuronate biosynthetic process","electron transfer activity;NAD binding;UDP-glucose 6-dehydrogenase activity","cytosol;extracellular exosome;nucleoplasm;nucleus","Amino sugar and nucleotide sugar metabolism;Ascorbate and aldarate metabolism;Metabolic pathways;Pentose and glucuronate interconversions",null,null,10,10,10,"27.9","27.9","27.9","55.023",0,"210.41",1216200000,67,"0.231711","0.792606","-0.252723","-0.642202","sp|O60701|UGDH_HUMAN;tr|E7ER95|E7ER95_HUMAN;tr|E7ER83|E7ER83_HUMAN;tr|E7ETF4|E7ETF4_HUMAN;tr|E7EV97|E7EV97_HUMAN;tr|D6RHF4|D6RHF4_HUMAN;tr|E9PBD2|E9PBD2_HUMAN","sp|O60701|UGDH_HUMAN",300,"O60701","UGDH_HUMAN","UDP-glucose 6-dehydrogenase","DPGDH;DP-Glc dehydrogenase;DP-GlcDH","UGDH"]
["19.6227","19.168","20.2725","19.024",{"$nulls":3},"apoptotic process;negative regulation of cell proliferation;positive regulation of aminoacyl-tRNA ligase activity;positive regulation of neuron death;positive regulation of protein ubiquitination;protein complex assembly;tRNA aminoacylation for protein translation;Type II pneumocyte differentiation","protein complex scaffold activity","aminoacyl-tRNA synthetase multienzyme complex;cytosol;membrane;nucleus",{"$nulls":3},5,5,5,"33.4","33.4","33.4","35.348",0,"134.92",164360000,21,"0.130738","0.898875","-0.252941","-0.380711","sp|Q13155|AIMP2_HUMAN;tr|A8MU58|A8MU58_HUMAN;tr|F8W950|F8W950_HUMAN","sp|Q13155|AIMP2_HUMAN;tr|A8MU58|A8MU58_HUMAN;tr|F8W950|F8W950_HUMAN",1529,"Q13155","AIMP2_HUMAN","Aminoacyl tRNA synthase complex-interacting multifunctional protein 2",null,"AIMP2"]
["18.5002","18.1923","19.0191","18.1794",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;clathrin-dependent endocytosis;endocytosis;ephrin receptor signaling pathway;Golgi to endosome transport;intracellular protein transport;low-density lipoprotein particle clearance;low-density lipoprotein particle receptor catabolic process;membrane organization;microtubule-based movement;negative regulation of hyaluronan biosynthetic process;positive regulation of neuron projection development;positive regulation of receptor-mediated endocytosis;regulation of defense response to virus by virus;Wnt signaling pathway, planar cell polarity pathway","low-density lipoprotein particle receptor binding;protein complex binding;protein C-terminus binding;protein kinase binding;protein transporter activity","AP-2 adaptor complex;apical plasma membrane;basolateral plasma membrane;clathrin coat of trans-Golgi network vesicle;clathrin-coated endocytic vesicle;clathrin-coated endocytic vesicle membrane;cytosol;endocytic vesicle membrane;endolysosome membrane;filopodium tip;membrane;plasma membrane","Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Huntington disease;Synaptic vesicle cycle",null,null,10,10,5,"16.6","16.6","10.7","107.54",0,"21.737",227940000,37,"0.201643","0.821573","-0.253004","-0.565748","sp|O95782|AP2A1_HUMAN;tr|E9PR62|E9PR62_HUMAN;tr|M0R2D9|M0R2D9_HUMAN;tr|E9PPZ3|E9PPZ3_HUMAN;tr|E9PS94|E9PS94_HUMAN;tr|E9PQP4|E9PQP4_HUMAN;tr|E9PPY8|E9PPY8_HUMAN;tr|A0A0G2JS17|A0A0G2JS17_HUMAN;tr|A0A0G2JQT9|A0A0G2JQT9_HUMAN;tr|H0YDE9|H0YDE9_HUMAN;tr|H0YEG0|H0YEG0_HUMAN;tr|A0A0G2JRF9|A0A0G2JRF9_HUMAN;tr|A0A0G2JQA4|A0A0G2JQA4_HUMAN","sp|O95782|AP2A1_HUMAN",449,"O95782","AP2A1_HUMAN","AP-2 complex subunit alpha-1",null,"AP2A1"]
["20.2273","19.8929","20.6055","20.0211",{"$nulls":9},1,1,1,"7.7","7.7","7.7","14.028","0.0020913","2.2204",95166000,5,"0.275343","0.755012","-0.253205","-0.75208","tr|H0YI92|H0YI92_HUMAN;tr|G3V1D4|G3V1D4_HUMAN;tr|H0YIA8|H0YIA8_HUMAN;sp|Q9NUP9|LIN7C_HUMAN;sp|Q9HAP6|LIN7B_HUMAN;sp|O14910|LIN7A_HUMAN","tr|H0YI92|H0YI92_HUMAN;tr|G3V1D4|G3V1D4_HUMAN;tr|H0YIA8|H0YIA8_HUMAN;sp|Q9NUP9|LIN7C_HUMAN;sp|Q9HAP6|LIN7B_HUMAN;sp|O14910|LIN7A_HUMAN",180,"H0YI92","H0YI92_HUMAN",null,null,"LIN7A"]
["21.4007","21.4625","21.9785","21.3915",{"$nulls":3},"aerobic respiration;AMP biosynthetic process;'de novo' AMP biosynthetic process;'de novo' IMP biosynthetic process;protein tetramerization;purine nucleotide biosynthetic process;purine ribonucleoside monophosphate biosynthetic process;response to hypoxia;response to muscle activity;response to nutrient;response to starvation","(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity;N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity","cytosol;mitochondrion","Alanine, aspartate and glutamate metabolism;Metabolic pathways;Purine metabolism",null,null,5,5,5,"11.8","11.8","11.8","54.889",0,"85.258",818630000,23,"0.317761","0.712888","-0.253379","-0.858444","sp|P30566|PUR8_HUMAN;tr|A0A0A6YY92|A0A0A6YY92_HUMAN;tr|A0A096LNY6|A0A096LNY6_HUMAN;tr|A0A096LPA2|A0A096LPA2_HUMAN;tr|A0A096LNY5|A0A096LNY5_HUMAN;tr|A0A096LP92|A0A096LP92_HUMAN;tr|B4DEP1|B4DEP1_HUMAN;tr|A0A096LP72|A0A096LP72_HUMAN;tr|A0A096LNY4|A0A096LNY4_HUMAN","sp|P30566|PUR8_HUMAN;tr|A0A0A6YY92|A0A0A6YY92_HUMAN;tr|A0A096LNY6|A0A096LNY6_HUMAN",875,"P30566","PUR8_HUMAN","Adenylosuccinate lyase {ECO:0000303|PubMed:8404037}","DSL {ECO:0000303|PubMed:8404037};SL","ADSL"]
["18.9893","18.8581","20.0773","18.2785",{"$nulls":3},"developmental process;G2/M transition of mitotic cell cycle;mitotic cell cycle;mitotic nuclear envelope reassembly;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;peptidyl-serine dephosphorylation;protein dephosphorylation;response to morphine","protein complex binding;protein phosphatase 2A binding;protein phosphatase regulator activity;protein serine/threonine phosphatase activity;tau protein binding","cytosol;nucleoplasm;protein phosphatase type 2A complex","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Chagas disease (American trypanosomiasis);Dopaminergic synapse;Hepatitis C;Hippo signaling pathway;Human papillomavirus infection;mRNA surveillance pathway;PI3K-Akt signaling pathway;Sphingolipid signaling pathway;Tight junction",null,null,3,3,3,"11.6","11.6","11.6","51.691",0,"10.656",128060000,15,"0.0944591","0.92103","-0.254197","-0.281877","sp|P63151|2ABA_HUMAN;tr|E5RIY1|E5RIY1_HUMAN;tr|E5RFR9|E5RFR9_HUMAN;sp|Q9Y2T4|2ABG_HUMAN","sp|P63151|2ABA_HUMAN;tr|E5RIY1|E5RIY1_HUMAN",1342,"P63151","2ABA_HUMAN","Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform",null,"PPP2R2A"]
["19.206","18.9631","19.3224","19.3552",{"$nulls":3},"protein polyubiquitination;proteolysis","aminopeptidase activity;endopeptidase activity;identical protein binding;serine-type endopeptidase activity;tripeptidyl-peptidase activity","cytoplasm;cytosol;nuclear body;nucleoplasm",{"$nulls":3},9,9,9,"11.4","11.4","11.4","138.35",0,"49.508",370500000,40,"0.760022","0.338166","-0.254253","-2.07419","sp|P29144|TPP2_HUMAN;tr|Q5VZU9|Q5VZU9_HUMAN","sp|P29144|TPP2_HUMAN;tr|Q5VZU9|Q5VZU9_HUMAN",843,"P29144","TPP2_HUMAN","Tripeptidyl-peptidase 2","PP-2","TPP2"]
["20.5476","20.7476","21.1638","20.6402",{"$nulls":3},"clathrin coat assembly;endocytosis","cadherin binding;clathrin binding;lipid binding","clathrin-coated vesicle;cytosol;Golgi apparatus;intracellular membrane-bounded organelle;membrane;nucleoplasm;perinuclear region of cytoplasm",{"$nulls":3},5,5,5,"12.3","12.3","12.3","68.259",0,"51.468",318420000,32,"0.33749","0.697758","-0.254422","-0.907961","sp|Q14677|EPN4_HUMAN;tr|H0YD52|H0YD52_HUMAN","sp|Q14677|EPN4_HUMAN",1636,"Q14677","EPN4_HUMAN","Clathrin interactor 1",null,"CLINT1"]
[1,"19.4276","19.9392",1,{"$nulls":3},"apoptotic process;cell cycle;cell proliferation;hyaluronan metabolic process;multicellular organism development;negative regulation of apoptotic process;negative regulation of DNA binding transcription factor activity;positive regulation of cardiac muscle cell proliferation;positive regulation of cardioblast proliferation;positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;protein autophosphorylation;protein phosphorylation;regulation of mitotic cell cycle;vitamin D receptor signaling pathway","ATP binding;manganese ion binding;protein serine/threonine kinase activity;ribosomal small subunit binding;transcription factor binding","cytoplasm;cytosol;nucleolus;nucleoplasm;nucleus;plasma membrane","Acute myeloid leukemia;AGE-RAGE signaling pathway in diabetic complications;Jak-STAT signaling pathway;MicroRNAs in cancer;Pathways in cancer",null,null,1,1,1,"2.2","2.2","2.2","45.412","0.0075808","1.7624",102640000,6,"0.00598579","0.989008","-0.255791","-0.0193599","sp|P11309|PIM1_HUMAN","sp|P11309|PIM1_HUMAN",628,"P11309","PIM1_HUMAN","Serine/threonine-protein kinase pim-1",null,"PIM1"]
["22.6191","22.4921","22.8032","22.8207",{"$nulls":3},"cellular response to oxidative stress;cholesterol biosynthetic process;erythrocyte maturation;glucose 6-phosphate metabolic process;glucose metabolic process;glutathione metabolic process;lipid metabolic process;NADP metabolic process;NADPH regeneration;negative regulation of cell growth involved in cardiac muscle cell development;negative regulation of protein glutathionylation;negative regulation of reactive oxygen species metabolic process;oxidation-reduction process;pentose biosynthetic process;pentose-phosphate shunt;pentose-phosphate shunt, oxidative branch;positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;regulation of neuron apoptotic process;response to ethanol;response to food;response to iron(III) ion;response to organic cyclic compound;ribose phosphate biosynthetic process;substantia nigra development","glucose binding;glucose-6-phosphate dehydrogenase activity;identical protein binding;NADP binding;protein homodimerization activity","cytoplasm;cytoplasmic side of plasma membrane;cytosol;extracellular exosome;membrane;nucleus","Carbon metabolism;Central carbon metabolism in cancer;Glutathione metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,13,13,13,"32.2","32.2","32.2","59.256",0,"59.728",2390300000,79,"1.24309","0.31887","-0.256377","-4.00209","sp|P11413|G6PD_HUMAN;tr|E7EUI8|E7EUI8_HUMAN;tr|E9PD92|E9PD92_HUMAN;tr|E7EM57|E7EM57_HUMAN","sp|P11413|G6PD_HUMAN;tr|E7EUI8|E7EUI8_HUMAN",631,"P11413","G6PD_HUMAN","Glucose-6-phosphate 1-dehydrogenase","6PD","G6PD"]
["18.6235","18.4588","19.2811","18.3141",{"$nulls":3},"COPII vesicle coating;ER to Golgi vesicle-mediated transport;IRE1-mediated unfolded protein response;protein exit from endoplasmic reticulum;protein secretion;regulation of COPII vesicle coating;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;GTPase activator activity;GTPase binding;guanyl-nucleotide exchange factor activity;Sar guanyl-nucleotide exchange factor activity","endoplasmic reticulum exit site;endoplasmic reticulum membrane;Golgi membrane;integral component of endoplasmic reticulum membrane;membrane;nucleus","Protein processing in endoplasmic reticulum",null,null,2,2,2,"7.2","7.2","7.2","45.468",0,"4.6546",63230000,7,"0.184967","0.834976","-0.256475","-0.522934","sp|Q9HCU5|PREB_HUMAN;tr|H7C2N7|H7C2N7_HUMAN;tr|B5MC98|B5MC98_HUMAN","sp|Q9HCU5|PREB_HUMAN;tr|H7C2N7|H7C2N7_HUMAN;tr|B5MC98|B5MC98_HUMAN",2648,"Q9HCU5","PREB_HUMAN","Prolactin regulatory element-binding protein",null,"PREB"]
["23.4626","23.6619","24.1983","23.44",{"$nulls":3},"CD4-positive, alpha-beta T cell activation;cellular calcium ion homeostasis;interleukin-2 production;lipid localization;mitochondrial ATP synthesis coupled proton transport;mitochondrial calcium ion transmembrane transport;mitochondrial protein processing;mitochondrion organization;positive regulation of cardiolipin metabolic process;positive regulation of mitochondrial DNA replication;positive regulation of mitochondrial membrane potential;protein oligomerization;stress-induced mitochondrial fusion;T cell receptor signaling pathway","cardiolipin binding;GTPase binding;receptor binding","cytoskeleton;extrinsic component of plasma membrane;membrane raft;mitochondrial inner membrane;mitochondrial intermembrane space",{"$nulls":3},13,13,13,"57.6","57.6","57.6","38.534",0,"248.39",2105500000,102,"0.236883","0.78792","-0.256878","-0.655282","sp|Q9UJZ1|STML2_HUMAN;tr|A0A087WYB4|A0A087WYB4_HUMAN;tr|F2Z2I8|F2Z2I8_HUMAN","sp|Q9UJZ1|STML2_HUMAN;tr|A0A087WYB4|A0A087WYB4_HUMAN",2864,"Q9UJZ1","STML2_HUMAN","Stomatin-like protein 2, mitochondrial","LP-2","STOML2"]
["21.8877","18.6568","21.3898","19.6693",{"$nulls":4},"RNA binding",{"$nulls":4},2,2,2,"36.8","36.8","36.8","8.6918",0,"10.842",235360000,9,"0.0452396","0.955761","-0.257313","-0.140592","tr|H0YJW7|H0YJW7_HUMAN;tr|A0A087WUN7|A0A087WUN7_HUMAN;tr|H0YJ40|H0YJ40_HUMAN;tr|G3V4X6|G3V4X6_HUMAN;sp|Q9GZT3|SLIRP_HUMAN;tr|G3V2S9|G3V2S9_HUMAN","tr|H0YJW7|H0YJW7_HUMAN;tr|A0A087WUN7|A0A087WUN7_HUMAN;tr|H0YJ40|H0YJ40_HUMAN;tr|G3V4X6|G3V4X6_HUMAN;sp|Q9GZT3|SLIRP_HUMAN;tr|G3V2S9|G3V2S9_HUMAN",2541,"H0YJW7","H0YJW7_HUMAN",null,null,"SLIRP"]
["20.7119","20.4607","21.2036","20.4846",{"$nulls":3},"intracellular protein transport;retrograde transport, endosome to Golgi;retrograde transport, endosome to plasma membrane;Wnt signaling pathway","zinc ion binding","cytosol;early endosome;endosome;endosome membrane;extracellular exosome;intracellular membrane-bounded organelle;late endosome;retromer complex;retromer, cargo-selective complex","Endocytosis",null,null,2,2,2,"12.1","12.1","12.1","20.505",0,"25.418",165360000,7,"0.245506","0.782443","-0.257805","-0.677046","sp|Q9UBQ0|VPS29_HUMAN;tr|F8VXU5|F8VXU5_HUMAN;tr|Q05DG7|Q05DG7_HUMAN","sp|Q9UBQ0|VPS29_HUMAN;tr|F8VXU5|F8VXU5_HUMAN;tr|Q05DG7|Q05DG7_HUMAN",2806,"Q9UBQ0","VPS29_HUMAN","Vacuolar protein sorting-associated protein 29","VPS29","VPS29"]
["20.6145","20.9664","21.0207","21.0759",{"$nulls":5},"mitochondrion;nucleolus",{"$nulls":3},3,3,3,"22.7","22.7","22.7","25.717",0,"39.202",144770000,19,"0.545711","0.485494","-0.257874","-1.44784","tr|C9JAZ1|C9JAZ1_HUMAN;sp|O75431|MTX2_HUMAN;tr|F8WE26|F8WE26_HUMAN;tr|C9JNK6|C9JNK6_HUMAN","tr|C9JAZ1|C9JAZ1_HUMAN;sp|O75431|MTX2_HUMAN",343,"C9JAZ1","C9JAZ1_HUMAN",null,null,"MTX2"]
["19.9063","20.3225","20.4503","20.2945",{"$nulls":3},"positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;transcription, DNA-templated","RNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytoplasm;membrane;nucleus",{"$nulls":3},8,8,8,"25.3","25.3","25.3","61.64",0,"38.365",321810000,47,"0.437203","0.567832","-0.258024","-1.16118","sp|Q96I24|FUBP3_HUMAN","sp|Q96I24|FUBP3_HUMAN",2293,"Q96I24","FUBP3_HUMAN","Far upstream element-binding protein 3","USE-binding protein 3","FUBP3"]
["20.3619","20.0915","20.8093","20.1603",{"$nulls":3},"activation of innate immune response;cellular response to exogenous dsRNA;defense response to bacterium;defense response to virus;innate immune response;negative regulation of type I interferon production;negative regulation of viral genome replication;positive regulation of chemokine (C-C motif) ligand 5 production;positive regulation of defense response to virus by host;positive regulation of DNA binding transcription factor activity;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-alpha secretion;positive regulation of interferon-beta production;positive regulation of interferon-beta secretion;positive regulation of interleukin-6 secretion;positive regulation of interleukin-8 production;positive regulation of IP-10 production;positive regulation of protein import into nucleus, translocation;positive regulation of protein phosphorylation;positive regulation of response to cytokine stimulus;positive regulation of transcription factor import into nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor production;positive regulation of tumor necrosis factor secretion;positive regulation of type I interferon-mediated signaling pathway;protein deubiquitination;regulation of peroxisome organization;signal transduction;viral process","CARD domain binding;protein kinase binding;signal transducer activity","integral component of membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrion;peroxisomal membrane","Cytosolic DNA-sensing pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Influenza A;Measles;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway",null,null,7,7,7,"27.8","27.8","27.8","56.527",0,"19.412",220720000,28,"0.268271","0.756202","-0.258149","-0.734325","sp|Q7Z434|MAVS_HUMAN","sp|Q7Z434|MAVS_HUMAN",1953,"Q7Z434","MAVS_HUMAN","Mitochondrial antiviral-signaling protein","AVS","MAVS"]
["21.8227","21.6832","22.242","21.7803",{"$nulls":4},"cadherin binding;calcium ion binding","membrane raft",{"$nulls":3},6,6,6,"22.9","22.9","22.9","26.697",0,"25.814",439780000,17,"0.401874","0.620995","-0.258195","-1.07067","sp|Q96C19|EFHD2_HUMAN;tr|H0Y4Y4|H0Y4Y4_HUMAN","sp|Q96C19|EFHD2_HUMAN;tr|H0Y4Y4|H0Y4Y4_HUMAN",2241,"Q96C19","EFHD2_HUMAN","EF-hand domain-containing protein D2",null,"EFHD2"]
["24.3494","24.341","24.8445","24.3627",{"$nulls":3},"canonical glycolysis;gluconeogenesis;glycolytic process;neutrophil degranulation;regulation of glycolytic process;regulation of pentose-phosphate shunt;respiratory burst","2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;bisphosphoglycerate mutase activity;hydrolase activity;phosphoglycerate mutase activity;protein kinase binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;secretory granule lumen","Biosynthesis of amino acids;Carbon metabolism;Central carbon metabolism in cancer;Glucagon signaling pathway;Glycine, serine and threonine metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways",null,null,12,12,12,"52.8","52.8","52.8","28.804",0,"77.007",3519900000,95,"0.402527","0.619082","-0.258391","-1.07234","sp|P18669|PGAM1_HUMAN;sp|P15259|PGAM2_HUMAN;sp|Q8N0Y7|PGAM4_HUMAN","sp|P18669|PGAM1_HUMAN;sp|P15259|PGAM2_HUMAN",723,"P18669","PGAM1_HUMAN","Phosphoglycerate mutase 1",null,"PGAM1"]
["17.8164","17.6376","18.3083","17.6649",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;bile acid biosynthetic process;cholesterol metabolic process;vesicle-mediated transport","cholesterol binding;phospholipid binding;sterol transporter activity","cytosol;extracellular exosome;intracellular;late endosome",{"$nulls":3},2,2,2,"2.2","2.2","2.2","108.47",0,"6.317",118170000,6,"0.285455","0.746399","-0.259579","-0.777448","sp|Q9BXW6|OSBL1_HUMAN;tr|J3QSB8|J3QSB8_HUMAN","sp|Q9BXW6|OSBL1_HUMAN;tr|J3QSB8|J3QSB8_HUMAN",2501,"Q9BXW6","OSBL1_HUMAN","Oxysterol-binding protein-related protein 1","RP-1;SBP-related protein 1","OSBPL1A"]
["21.8294","21.6457","22.2569","21.7382",{"$nulls":3},"cell-cell junction assembly;cell-substrate junction assembly;cortical actin cytoskeleton organization;cytoskeletal anchoring at plasma membrane;integrin activation;integrin-mediated signaling pathway;IRE1-mediated unfolded protein response;movement of cell or subcellular component;muscle contraction;platelet aggregation;platelet degranulation;viral process","actin filament binding;cadherin binding;integrin binding;LIM domain binding;phosphatidylinositol binding;phosphatidylserine binding;structural constituent of cytoskeleton;vinculin binding","cell surface;cell-cell junction;cytoskeleton;cytosol;extracellular exosome;extracellular region;focal adhesion;ruffle;ruffle membrane","Focal adhesion;Human T-cell leukemia virus 1 infection;Platelet activation;Rap1 signaling pathway",null,null,57,57,57,"37.7","37.7","37.7","269.76",0,"323.31",5798700000,308,"0.352229","0.684305","-0.259976","-0.945028","sp|Q9Y490|TLN1_HUMAN;sp|Q9Y4G6|TLN2_HUMAN;tr|H0YMT1|H0YMT1_HUMAN","sp|Q9Y490|TLN1_HUMAN",2993,"Q9Y490","TLN1_HUMAN","Talin-1",null,"TLN1"]
["22.9917","22.91","23.252","23.1702",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","cadherin binding;endopeptidase activity;threonine-type endopeptidase activity","cytosol;extracellular exosome;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex","Proteasome",null,null,4,4,4,"33.5","33.5","33.5","25.357",0,"37.571",930600000,25,"1.33737","0.336195","-0.26024","-4.5008","sp|P28072|PSB6_HUMAN;tr|A0A087X2I4|A0A087X2I4_HUMAN;tr|I3L3X7|I3L3X7_HUMAN","sp|P28072|PSB6_HUMAN;tr|A0A087X2I4|A0A087X2I4_HUMAN;tr|I3L3X7|I3L3X7_HUMAN",834,"P28072","PSB6_HUMAN","Proteasome subunit beta type-6",null,"PSMB6"]
["22.4057","21.9136","22.7295","22.111",{"$nulls":3},"10-formyltetrahydrofolate biosynthetic process;embryonic neurocranium morphogenesis;embryonic viscerocranium morphogenesis;folic acid metabolic process;heart development;histidine biosynthetic process;methionine biosynthetic process;methionine metabolic process;neural tube closure;neutrophil homeostasis;one-carbon metabolic process;purine nucleobase biosynthetic process;purine nucleotide biosynthetic process;serine family amino acid biosynthetic process;serine family amino acid metabolic process;somite development;tetrahydrofolate interconversion;transsulfuration","ATP binding;formate-tetrahydrofolate ligase activity;methenyltetrahydrofolate cyclohydrolase activity;methylenetetrahydrofolate dehydrogenase (NAD+) activity;methylenetetrahydrofolate dehydrogenase (NADP+) activity;methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity","cytoplasm;cytosol;extracellular exosome;membrane;mitochondrion","Metabolic pathways;One carbon pool by folate",null,null,26,26,26,"34.3","34.3","34.3","101.56",0,"105.6",2994000000,107,"0.238512","0.787453","-0.260614","-0.659396","sp|P11586|C1TC_HUMAN;tr|F5H2F4|F5H2F4_HUMAN;tr|V9GYY3|V9GYY3_HUMAN","sp|P11586|C1TC_HUMAN;tr|F5H2F4|F5H2F4_HUMAN",634,"P11586","C1TC_HUMAN","C-1-tetrahydrofolate synthase, cytoplasmic","1-THF synthase","MTHFD1"]
["20.3734","20.19","20.623","20.4616",{"$nulls":3},"biotin metabolic process;branched-chain amino acid catabolic process;coenzyme A metabolic process;leucine catabolic process;protein heterooligomerization","ATP binding;methylcrotonoyl-CoA carboxylase activity","3-methylcrotonyl-CoA carboxylase complex, mitochondrial;cytosol;methylcrotonoyl-CoA carboxylase complex;mitochondrial matrix;mitochondrion","Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,8,8,8,"21.5","21.5","21.5","61.332",0,"38.492",339060000,39,"0.778812","0.336914","-0.260627","-2.13413","sp|Q9HCC0|MCCB_HUMAN;tr|D6RD67|D6RD67_HUMAN;tr|D6R9R1|D6R9R1_HUMAN;tr|D6RDF7|D6RDF7_HUMAN;tr|A0A0G2JM88|A0A0G2JM88_HUMAN","sp|Q9HCC0|MCCB_HUMAN;tr|D6RD67|D6RD67_HUMAN",2642,"Q9HCC0","MCCB_HUMAN","Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial","CCase subunit beta","MCCC2"]
["16.9825","16.827","17.659","16.6718",{"$nulls":3},"muscle contraction",{"$nulls":5},1,1,1,"8.2","8.2","8.2","19.334","0.0011257","2.8038",13442000,4,"0.184446","0.834046","-0.260639","-0.521592","tr|H7C5G9|H7C5G9_HUMAN;tr|H7BZK0|H7BZK0_HUMAN;sp|Q14BN4|SLMAP_HUMAN","tr|H7C5G9|H7C5G9_HUMAN;tr|H7BZK0|H7BZK0_HUMAN;sp|Q14BN4|SLMAP_HUMAN",1653,"H7C5G9","H7C5G9_HUMAN",null,null,"SLMAP"]
["22.0453","21.9625","22.4578","22.0746",{"$nulls":3},"box C/D snoRNP assembly;cellular response to estradiol stimulus;cellular response to UV;chromatin remodeling;DNA recombination;DNA repair;establishment of protein localization to chromatin;histone H2A acetylation;histone H4 acetylation;negative regulation of estrogen receptor binding;positive regulation of histone acetylation;positive regulation of telomerase RNA localization to Cajal body;positive regulation of transcription from RNA polymerase II promoter;protein folding;regulation of growth;transcription, DNA-templated;transcriptional activation by promoter-enhancer looping","ADP binding;ATP binding;ATPase binding;ATP-dependent 5'-3' DNA helicase activity;ATP-dependent DNA helicase activity;chromatin DNA binding;DNA helicase activity;identical protein binding;protein homodimerization activity;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II distal enhancer sequence-specific DNA binding;TFIID-class transcription factor binding;unfolded protein binding","centrosome;cytosol;extracellular exosome;Ino80 complex;intracellular;intracellular ribonucleoprotein complex;membrane;MLL1 complex;NuA4 histone acetyltransferase complex;nuclear euchromatin;nuclear matrix;nucleoplasm;nucleus;R2TP complex;Swr1 complex",{"$nulls":3},13,13,13,"31.5","31.5","31.5","51.156",0,"56.505",1139100000,68,"0.504824","0.514234","-0.262275","-1.33801","sp|Q9Y230|RUVB2_HUMAN;tr|M0R0Y3|M0R0Y3_HUMAN;tr|X6R2L4|X6R2L4_HUMAN;tr|M0QXI6|M0QXI6_HUMAN;tr|M0R0Z0|M0R0Z0_HUMAN","sp|Q9Y230|RUVB2_HUMAN;tr|M0R0Y3|M0R0Y3_HUMAN",2936,"Q9Y230","RUVB2_HUMAN","RuvB-like 2",null,"RUVBL2"]
["17.8718","17.8478","18.8777","17.3672",{"$nulls":3},"apoptotic nuclear changes;brain development;cell proliferation;endoplasmic reticulum unfolded protein response;mitotic G2 DNA damage checkpoint;mitotic G2/M transition checkpoint;negative regulation of cellular protein catabolic process;negative regulation of MAP kinase activity;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein kinase activity by regulation of protein phosphorylation;negative regulation of protein phosphorylation;negative regulation of protein serine/threonine kinase activity;positive regulation of protein localization to nucleus;positive regulation of protein ubiquitination;positive regulation of signal transduction by p53 class mediator;positive regulation of transcription from RNA polymerase II promoter;protein ufmylation;regulation of cyclin-dependent protein serine/threonine kinase activity;regulation of neuron differentiation;regulation of phosphatase activity","cyclin binding;MDM2/MDM4 family protein binding;mitogen-activated protein kinase binding;NF-kappaB binding;protein kinase binding;ubiquitin-like protein ligase binding","centrosome;cytoplasm;cytosol;endomembrane system;membrane;nucleolus;nucleus;protein complex",{"$nulls":3},3,3,3,"7.5","7.5","7.5","56.92",0,"4.1909",81974000,7,"0.118469","0.904307","-0.262621","-0.347688","sp|Q96JB5|CK5P3_HUMAN;tr|J3QRM1|J3QRM1_HUMAN;tr|J3QL86|J3QL86_HUMAN;tr|J3QQY1|J3QQY1_HUMAN","sp|Q96JB5|CK5P3_HUMAN;tr|J3QRM1|J3QRM1_HUMAN",2304,"Q96JB5","CK5P3_HUMAN","CDK5 regulatory subunit-associated protein 3 {ECO:0000312}",null,"CDK5RAP3"]
["20.4105","20.1945","20.6741","20.4566",{"$nulls":3},"mitochondrial calcium ion transmembrane transport;protein processing involved in protein targeting to mitochondrion;proteolysis","metalloendopeptidase activity;zinc ion binding","extracellular space;mitochondrial inner membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},8,8,8,"19.6","19.6","19.6","58.252",0,"24.321",373680000,18,"0.641261","0.403641","-0.262877","-1.71532","sp|Q10713|MPPA_HUMAN","sp|Q10713|MPPA_HUMAN",1488,"Q10713","MPPA_HUMAN","Mitochondrial-processing peptidase subunit alpha",null,"PMPCA"]
["18.9214","18.851","19.3134","18.985",{"$nulls":3},"brain development;copper ion transport;generation of precursor metabolites and energy;heart development;mitochondrial respiratory chain complex IV assembly;positive regulation of cell proliferation;positive regulation of cytochrome-c oxidase activity","copper chaperone activity;copper ion binding;cuprous ion binding","cytoplasm;mitochondrial intermembrane space","Metabolic pathways;Oxidative phosphorylation;Thermogenesis",null,null,1,1,1,"25.4","25.4","25.4","6.9151","0.0011274","2.8146",18938000,6,"0.588595","0.449177","-0.262983","-1.56585","sp|Q14061|COX17_HUMAN;tr|C9J8T6|C9J8T6_HUMAN","sp|Q14061|COX17_HUMAN;tr|C9J8T6|C9J8T6_HUMAN",1598,"Q14061","COX17_HUMAN","Cytochrome c oxidase copper chaperone",null,"COX17"]
["18.0225","16.0881","18.4166","16.2201",{"$nulls":3},"chromatin silencing;mitochondrion organization;negative regulation of cardiac muscle cell apoptotic process;negative regulation of reactive oxygen species metabolic process;peptidyl-lysine demalonylation;peptidyl-lysine desuccinylation;protein ADP-ribosylation;protein deacetylation;protein deglutarylation;protein demalonylation;protein desuccinylation;regulation of ketone biosynthetic process;response to nutrient levels","NAD+ ADP-ribosyltransferase activity;NAD+ binding;NAD-dependent protein deacetylase activity;protein-glutaryllysine deglutarylase activity;protein-malonyllysine demalonylase activity;protein-succinyllysine desuccinylase activity;zinc ion binding","cytosol;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;nucleus",{"$nulls":3},2,2,2,"10.6","10.6","10.6","33.881",0,"4.47",37298000,12,"0.0585288","0.944051","-0.263042","-0.17974","sp|Q9NXA8|SIR5_HUMAN","sp|Q9NXA8|SIR5_HUMAN",2738,"Q9NXA8","SIR5_HUMAN","NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}",null,"SIRT5"]
["19.9105","19.1342","20.3758","19.1954",{"$nulls":3},"Golgi organization;organelle organization",null,"Golgi apparatus;Golgi membrane;membrane",{"$nulls":3},5,5,5,"18.6","18.6","18.6","47.145",0,"40.656",159060000,29,"0.127733","0.896858","-0.263246","-0.372656","sp|Q9H8Y8|GORS2_HUMAN","sp|Q9H8Y8|GORS2_HUMAN",2616,"Q9H8Y8","GORS2_HUMAN","Golgi reassembly-stacking protein 2","RS2","GORASP2"]
["21.8613","20.8849","22.1519","21.1216",{"$nulls":3},"cell cycle arrest;peptidyl-threonine dephosphorylation;protein dephosphorylation","metal ion binding;protein serine/threonine phosphatase activity","cytoplasm;membrane;nucleoplasm;nucleus",{"$nulls":3},11,11,11,"34.1","34.1","34.1","59.271",0,"104.36",837840000,74,"0.127276","0.896754","-0.263629","-0.37143","sp|O15355|PPM1G_HUMAN","sp|O15355|PPM1G_HUMAN",215,"O15355","PPM1G_HUMAN","Protein phosphatase 1G",null,"PPM1G"]
["16.6885","16.4166","16.8694","16.7632",{"$nulls":3},"fatty acid beta-oxidation;fatty acid biosynthetic process;peroxisomal long-chain fatty acid import;peroxisome organization;response to drug;response to organic cyclic compound;transmembrane transport;very long-chain fatty acid catabolic process","ATP binding;ATPase activity;ATPase activity, coupled to transmembrane movement of substances;long-chain fatty acid transporter activity;protein homodimerization activity;protein self-association","cytosol;integral component of membrane;intracellular membrane-bounded organelle;membrane;mitochondrial inner membrane;peroxisomal matrix;peroxisomal membrane;peroxisome","ABC transporters;Peroxisome",null,null,2,2,2,"4.4","4.4","4.4","75.475","0.00075815","2.8844",44384000,4,"0.672574","0.38339","-0.263743","-1.80682","sp|P28288|ABCD3_HUMAN","sp|P28288|ABCD3_HUMAN",836,"P28288","ABCD3_HUMAN","ATP-binding cassette sub-family D member 3",null,"ABCD3"]
["17.451","16.2996","17.9331","16.3455",{"$nulls":3},"intracellular protein transport;negative regulation of mitotic nuclear division;signal transduction","clathrin binding;protein kinase binding","extracellular exosome;intracellular",{"$nulls":3},4,4,4,"16.8","16.8","16.8","55.556",0,"10.887",45436000,7,"0.0899283","0.921752","-0.264031","-0.269259","sp|Q6ZVM7|TM1L2_HUMAN;tr|B7Z2U2|B7Z2U2_HUMAN;tr|F5H3S6|F5H3S6_HUMAN;tr|K7ENB0|K7ENB0_HUMAN","sp|Q6ZVM7|TM1L2_HUMAN;tr|B7Z2U2|B7Z2U2_HUMAN;tr|F5H3S6|F5H3S6_HUMAN",1920,"Q6ZVM7","TM1L2_HUMAN","TOM1-like protein 2",null,"TOM1L2"]
["18.8669",1,"19.3956",1,{"$nulls":5},"nucleus",{"$nulls":3},1,1,1,"10.3","10.3","10.3","12.643","0.006","1.8599",4671100,3,"0.00637738","0.98862","-0.264359","-0.0206174","tr|D6RCQ4|D6RCQ4_HUMAN;tr|D6RAY9|D6RAY9_HUMAN;tr|D6REL4|D6REL4_HUMAN;tr|Q9H4P6|Q9H4P6_HUMAN;tr|E7EQZ7|E7EQZ7_HUMAN;sp|Q13123|RED_HUMAN","tr|D6RCQ4|D6RCQ4_HUMAN;tr|D6RAY9|D6RAY9_HUMAN;tr|D6REL4|D6REL4_HUMAN;tr|Q9H4P6|Q9H4P6_HUMAN;tr|E7EQZ7|E7EQZ7_HUMAN;sp|Q13123|RED_HUMAN",1522,"D6RCQ4","D6RCQ4_HUMAN",null,null,"IK"]
["14.8683","14.6346","15.6533","14.3792",{"$nulls":3},"blastocyst growth;cellular response to lipopolysaccharide;endodermal cell fate commitment;histone H2B ubiquitination;histone H3-K4 trimethylation;histone monoubiquitination;inner cell mass cell differentiation;interleukin-6-mediated signaling pathway;JAK-STAT cascade;negative regulation of mRNA polyadenylation;negative regulation of myeloid cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of histone H2B ubiquitination;positive regulation of histone H3-K4 methylation;positive regulation of histone H3-K79 methylation;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein ubiquitination;regulation of genetic imprinting;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;trophectodermal cell differentiation;Wnt signaling pathway","RNA polymerase II core binding;SH2 domain binding","Cdc73/Paf1 complex;nuclear speck;nucleoplasm;transcriptionally active chromatin",{"$nulls":3},1,1,1,"1.2","1.2","1.2","133.5","0.0010819","2.4756",19970000,2,"0.141262","0.884083","-0.264743","-0.408752","sp|Q6PD62|CTR9_HUMAN","sp|Q6PD62|CTR9_HUMAN",1891,"Q6PD62","CTR9_HUMAN","RNA polymerase-associated protein CTR9 homolog",null,"CTR9"]
["20.1917","19.834","20.7041","19.8514",{"$nulls":3},"cognition;phylloquinone catabolic process;xenobiotic metabolic process","3-keto sterol reductase activity;carbonyl reductase (NADPH) activity;NADPH binding","cytosol;extracellular space;nucleoplasm","Arachidonic acid metabolism;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450",null,null,6,4,4,"33.6","23.1","23.1","30.85",0,"7.6386",183460000,13,"0.204466","0.818183","-0.264922","-0.572961","sp|O75828|CBR3_HUMAN","sp|O75828|CBR3_HUMAN",369,"O75828","CBR3_HUMAN","Carbonyl reductase [NADPH] 3",null,"CBR3"]
["18.7445","18.6231","19.1635","18.7344",{"$nulls":4},"carbohydrate binding","integral component of membrane;membrane",{"$nulls":3},8,8,8,"8.5","8.5","8.5","134.32",0,"77.451",265240000,36,"0.44793","0.554172","-0.265113","-1.18888","sp|Q15155|NOMO1_HUMAN;tr|A0A0G2JN29|A0A0G2JN29_HUMAN;tr|A0A087X117|A0A087X117_HUMAN;tr|A0A0G2JP90|A0A0G2JP90_HUMAN;tr|A0A087WW46|A0A087WW46_HUMAN;sp|P69849|NOMO3_HUMAN;tr|J3KN36|J3KN36_HUMAN;sp|Q5JPE7|NOMO2_HUMAN;tr|H3BUC9|H3BUC9_HUMAN;tr|A0A087WTD5|A0A087WTD5_HUMAN","sp|Q15155|NOMO1_HUMAN;tr|A0A0G2JN29|A0A0G2JN29_HUMAN;tr|A0A087X117|A0A087X117_HUMAN;tr|A0A0G2JP90|A0A0G2JP90_HUMAN;tr|A0A087WW46|A0A087WW46_HUMAN;sp|P69849|NOMO3_HUMAN;tr|J3KN36|J3KN36_HUMAN;sp|Q5JPE7|NOMO2_HUMAN",1680,"Q15155","NOMO1_HUMAN","Nodal modulator 1",null,"NOMO1"]
["17.1111","16.7488","17.1759","17.2147",{"$nulls":3},"cleavage furrow formation;endocytosis;endosomal transport;mitotic cytokinesis;positive regulation of GTPase activity;protein transport","phosphatidylinositol-4,5-bisphosphate binding","cytoplasmic vesicle;cytoplasmic vesicle membrane;endosome membrane;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane",{"$nulls":3},1,1,1,"2.7","2.7","2.7","68.894",0,"5.7946",40500000,8,"0.549016","0.481636","-0.26534","-1.45683","sp|Q96RF0|SNX18_HUMAN","sp|Q96RF0|SNX18_HUMAN",2343,"Q96RF0","SNX18_HUMAN","Sorting nexin-18",null,"SNX18"]
["17.6526","16.3451","18.0753","16.4533",{"$nulls":3},"bicellular tight junction assembly;dendrite development;locomotory behavior;negative regulation of cell proliferation;Wnt signaling pathway","armadillo repeat domain binding;calmodulin binding;estrogen receptor binding;protein complex binding;protein phosphatase 2A binding","bicellular tight junction;cytoplasm;dendritic spine;membrane;neuronal cell body;postsynaptic density;postsynaptic membrane",{"$nulls":3},5,5,5,"10.4","10.4","10.4","86.131",0,"13.371",86368000,12,"0.0847672","0.926424","-0.26542","-0.254801","sp|O43815|STRN_HUMAN","sp|O43815|STRN_HUMAN",268,"O43815","STRN_HUMAN","Striatin",null,"STRN"]
["17.4794","17.1947","17.1269","18.0792",{"$nulls":3},"actin rod assembly;cellular response to ATP;positive regulation of actin filament depolymerization;protein dephosphorylation;pyridoxal phosphate catabolic process;regulation of cytokinesis;regulation of mitotic nuclear division","heat shock protein binding;magnesium ion binding;nucleotide phosphatase activity, acting on free nucleotides;phosphoprotein phosphatase activity;phosphoserine phosphatase activity;pyridoxal phosphatase activity","cytoskeleton;cytosol;extracellular exosome;lamellipodium membrane;ruffle membrane","Metabolic pathways;Vitamin B6 metabolism",null,null,1,1,1,"4.7","4.7","4.7","31.698",0,"3.6626",24145000,4,"0.18975","0.830894","-0.266013","-0.535248","sp|Q96GD0|PLPP_HUMAN","sp|Q96GD0|PLPP_HUMAN",2278,"Q96GD0","PLPP_HUMAN","Pyridoxal phosphate phosphatase","LP phosphatase","PDXP"]
["24.0516","24.015","24.5951","24.0036",{"$nulls":3},"cytoplasmic translation;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal large subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","DNA binding;mRNA binding;protein homodimerization activity;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleus","Ribosome",null,null,9,9,9,"35.5","35.5","35.5","29.225",0,"52.099",2360500000,43,"0.333491","0.701748","-0.266066","-0.897916","sp|P18124|RL7_HUMAN;tr|A8MUD9|A8MUD9_HUMAN;tr|C9JIJ5|C9JIJ5_HUMAN;tr|C9JZ88|C9JZ88_HUMAN","sp|P18124|RL7_HUMAN;tr|A8MUD9|A8MUD9_HUMAN",719,"P18124","RL7_HUMAN","60S ribosomal protein L7",null,"RPL7"]
["21.032","19.7309","21.509","19.7862",{"$nulls":3},"5-phosphoribose 1-diphosphate biosynthetic process;hypoxanthine biosynthetic process;nervous system development;nucleoside metabolic process;purine nucleobase metabolic process;purine nucleotide biosynthetic process;pyrimidine nucleotide biosynthetic process;ribonucleoside monophosphate biosynthetic process;urate biosynthetic process","ATP binding;identical protein binding;kinase activity;magnesium ion binding;protein homodimerization activity;ribose phosphate diphosphokinase activity","cytosol","Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Pentose phosphate pathway;Purine metabolism",null,null,4,4,3,"15.7","15.7","10.4","34.834",0,"103.24",431150000,18,"0.0818367","0.929036","-0.266142","-0.24655","sp|P60891|PRPS1_HUMAN;tr|B1ALA9|B1ALA9_HUMAN;tr|A0A0B4J207|A0A0B4J207_HUMAN;sp|P21108|PRPS3_HUMAN;tr|B7ZB02|B7ZB02_HUMAN;tr|B1ALA7|B1ALA7_HUMAN;tr|H7C540|H7C540_HUMAN","sp|P60891|PRPS1_HUMAN;tr|B1ALA9|B1ALA9_HUMAN;tr|A0A0B4J207|A0A0B4J207_HUMAN;sp|P21108|PRPS3_HUMAN",1243,"P60891","PRPS1_HUMAN","Ribose-phosphate pyrophosphokinase 1",null,"PRPS1"]
["20.5882","20.8025","21.2235","20.7016",{"$nulls":3},"cation transmembrane transport;magnesium ion transport","inorganic cation transmembrane transporter activity;magnesium ion transmembrane transporter activity","early endosome;early endosome membrane;ER membrane protein complex;Golgi apparatus;Golgi membrane;integral component of membrane;membrane;plasma membrane",{"$nulls":3},1,1,1,"18.3","18.3","18.3","14.686","0.00040209","3.4034",86191000,9,"0.353039","0.683057","-0.267157","-0.947067","sp|Q8N4V1|MMGT1_HUMAN","sp|Q8N4V1|MMGT1_HUMAN",2052,"Q8N4V1","MMGT1_HUMAN","Membrane magnesium transporter 1",null,"MMGT1"]
["19.8907","19.8285","20.7347","19.5204",{"$nulls":4},"metal ion binding","integral component of membrane",{"$nulls":3},1,1,1,"12.2","12.2","12.2","12.976",0,"13.135",28790000,8,"0.153353","0.874707","-0.267915","-0.44068","tr|E9PP55|E9PP55_HUMAN;sp|Q96K19|RN170_HUMAN","tr|E9PP55|E9PP55_HUMAN;sp|Q96K19|RN170_HUMAN",2312,"E9PP55","E9PP55_HUMAN",null,null,"RNF170"]
["23.3015","23.2399","23.6134","23.4645",{"$nulls":3},"activation of innate immune response;brain development;cellular hyperosmotic salinity response;cellular response to gamma radiation;cellular response to X-ray;DNA ligation;DNA recombination;double-strand break repair via classical nonhomologous end joining;double-strand break repair via nonhomologous end joining;establishment of integrated proviral latency;innate immune response;negative regulation of transcription, DNA-templated;neutrophil degranulation;positive regulation of protein kinase activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;protein heterotetramerization;regulation of smooth muscle cell proliferation;telomere maintenance;transcription, DNA-templated","5'-deoxyribose-5-phosphate lyase activity;ATP binding;ATP-dependent DNA helicase activity;cyclin binding;damaged DNA binding;DNA binding;double-stranded DNA binding;macromolecular complex binding;protein C-terminus binding;RNA binding;telomeric DNA binding;transcription regulatory region DNA binding","cytosol;extracellular region;ficolin-1-rich granule lumen;Ku70:Ku80 complex;membrane;nonhomologous end joining complex;nuclear chromosome, telomeric region;nuclear telomere cap complex;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;secretory granule lumen;transcription factor complex","Non-homologous end-joining",null,null,24,24,24,"46.1","46.1","46.1","69.842",0,"323.31",3294900000,146,"1.09945","0.308627","-0.268276","-3.33077","sp|P12956|XRCC6_HUMAN;tr|B1AHC9|B1AHC9_HUMAN","sp|P12956|XRCC6_HUMAN;tr|B1AHC9|B1AHC9_HUMAN",651,"P12956","XRCC6_HUMAN","X-ray repair cross-complementing protein 6",null,"XRCC6"]
["20.4056","20.0401","20.3427","20.6399",{"$nulls":3},"transcription, DNA-templated",{"$nulls":5},2,2,2,"21.6","21.6","21.6","16.925",0,"9.453",129350000,9,"0.428799","0.584138","-0.268441","-1.13955","tr|C9JLU1|C9JLU1_HUMAN;sp|P52434|RPAB3_HUMAN","tr|C9JLU1|C9JLU1_HUMAN;sp|P52434|RPAB3_HUMAN",1157,"C9JLU1","C9JLU1_HUMAN",null,null,"POLR2H"]
["19.9745","20.0462","20.5716","19.9861",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell division;ER to Golgi vesicle-mediated transport;microtubule cytoskeleton organization;microtubule-based movement;neutrophil degranulation;positive regulation of mitotic cell cycle spindle assembly checkpoint;sister chromatid cohesion;viral process","ATP binding;dynein heavy chain binding;GDP binding;microtubule motor activity;RNA binding","centrosome;condensed chromosome kinetochore;cytoplasmic dynein complex;cytosol;ficolin-1-rich granule membrane;kinetochore;membrane;microtubule;plasma membrane;secretory granule membrane;spindle pole","Phagosome;Salmonella infection;Vasopressin-regulated water reabsorption",null,null,7,7,7,21,21,21,"56.578",0,"39.971",355920000,36,"0.338414","0.697849","-0.268505","-0.910282","sp|Q9Y6G9|DC1L1_HUMAN;tr|E9PHI6|E9PHI6_HUMAN;tr|C9JGM7|C9JGM7_HUMAN;tr|C9JLW1|C9JLW1_HUMAN","sp|Q9Y6G9|DC1L1_HUMAN;tr|E9PHI6|E9PHI6_HUMAN",3051,"Q9Y6G9","DC1L1_HUMAN","Cytoplasmic dynein 1 light intermediate chain 1","IC1","DYNC1LI1"]
["19.8137","19.4805","20.6371","19.1954",{"$nulls":3},"ER to Golgi vesicle-mediated transport;establishment of Golgi localization;intracellular protein transport;organelle transport along microtubule;retrograde vesicle-mediated transport, Golgi to ER","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;transport vesicle",{"$nulls":3},9,9,8,"13.6","13.6","12.2","97.717",0,"91.044",530700000,48,"0.124428","0.901448","-0.269124","-0.363775","sp|Q9Y678|COPG1_HUMAN;tr|H0Y8X7|H0Y8X7_HUMAN","sp|Q9Y678|COPG1_HUMAN",3040,"Q9Y678","COPG1_HUMAN","Coatomer subunit gamma-1",null,"COPG1"]
["19.5003","19.4575","19.8522","19.6441",{"$nulls":3},"biosynthetic process","catalytic activity",{"$nulls":4},3,3,3,"12.3","12.3","12.3","33.711",0,"6.6899",130310000,15,"0.897072","0.298828","-0.269284","-2.53451","tr|C9J050|C9J050_HUMAN;sp|P49585|PCY1A_HUMAN;tr|C9JEJ2|C9JEJ2_HUMAN;tr|F8WBU2|F8WBU2_HUMAN;tr|C9JVS0|C9JVS0_HUMAN;tr|C9JPY0|C9JPY0_HUMAN;tr|F8WAZ5|F8WAZ5_HUMAN;tr|H7BZN1|H7BZN1_HUMAN;tr|H7C1T3|H7C1T3_HUMAN;tr|C9J2E1|C9J2E1_HUMAN;sp|Q9Y5K3|PCY1B_HUMAN","tr|C9J050|C9J050_HUMAN;sp|P49585|PCY1A_HUMAN;tr|C9JEJ2|C9JEJ2_HUMAN",1079,"C9J050","C9J050_HUMAN",null,null,"PCYT1A"]
["18.0275","17.9644","18.8419","17.6887",{"$nulls":3},"apoptotic process;L-methionine salvage from methylthioadenosine;negative regulation of apoptotic process;protein homotetramerization;pyroptosis;regulation of ERK1 and ERK2 cascade","identical protein binding;methylthioribulose 1-phosphate dehydratase activity;zinc ion binding","cytoplasm","Cysteine and methionine metabolism;Metabolic pathways",null,null,2,2,2,"12.8","12.8","12.8","27.125",0,"5.7347",48344000,10,"0.1632","0.862591","-0.26936","-0.466476","sp|Q96GX9|MTNB_HUMAN;tr|S4R3D6|S4R3D6_HUMAN","sp|Q96GX9|MTNB_HUMAN;tr|S4R3D6|S4R3D6_HUMAN",2284,"Q96GX9","MTNB_HUMAN","Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}","TRu-1-P dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}","APIP"]
["16.7668","16.6075","17.2503","16.6646",{"$nulls":3},"cell growth;rRNA modification;rRNA processing;snoRNA localization","ATPase binding;RNA binding;snoRNA binding;TFIID-class transcription factor binding","box C/D snoRNP complex;Cajal body;cytosol;fibrillar center;membrane;nucleolus;nucleoplasm;nucleus;pre-snoRNP complex;small nucleolar ribonucleoprotein complex;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,2,2,2,"5.9","5.9","5.9","59.578","0.0011182","2.7709",22990000,6,"0.330549","0.703415","-0.270273","-0.890531","sp|Q9Y2X3|NOP58_HUMAN;tr|H7BZ72|H7BZ72_HUMAN","sp|Q9Y2X3|NOP58_HUMAN;tr|H7BZ72|H7BZ72_HUMAN",2962,"Q9Y2X3","NOP58_HUMAN","Nucleolar protein 58",null,"NOP58"]
["16.4045","16.29","16.6795","16.5556",{"$nulls":3},"anatomical structure morphogenesis;angiogenesis;cell adhesion;glomerular filtration;positive regulation of cell migration;vascular wound healing",null,"external side of plasma membrane;extracellular region;extracellular space;focal adhesion;integral component of membrane;nucleus;plasma membrane",{"$nulls":3},2,2,2,"4.8","4.8","4.8","71.607",0,"3.6226",37451000,3,"1.07007","0.303737","-0.270305","-3.20516","sp|P43121|MUC18_HUMAN","sp|P43121|MUC18_HUMAN",1003,"P43121","MUC18_HUMAN","Cell surface glycoprotein MUC18",null,"MCAM"]
["18.4993","18.5689","19.0085","18.6008",{"$nulls":3},"cellular response to leukemia inhibitory factor;defense response to virus;ERAD pathway;innate immune response;interferon-gamma-mediated signaling pathway;negative regulation of type I interferon production;negative regulation of viral entry into host cell;negative regulation of viral release from host cell;positive regulation of DNA binding transcription factor activity;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;protein deubiquitination;protein monoubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of viral entry into host cell;regulation of viral release from host cell;response to estrogen;response to vitamin D;translesion synthesis;viral process","cadherin binding;DNA binding transcription factor activity;ligase activity;RNA binding;ubiquitin protein ligase activity involved in ERAD pathway;ubiquitin-protein transferase activity;zinc ion binding","cytosol;nuclear body;nucleoplasm","Influenza A;NF-kappa B signaling pathway;RIG-I-like receptor signaling pathway",null,null,3,3,3,"3.7","3.7","3.7","70.973",0,"9.9055",112720000,17,"0.493544","0.519092","-0.270556","-1.30813","sp|Q14258|TRI25_HUMAN","sp|Q14258|TRI25_HUMAN",1617,"Q14258","TRI25_HUMAN","E3 ubiquitin/ISG15 ligase TRIM25",null,"TRIM25"]
["20.3443","19.7021","20.9834","19.6043",{"$nulls":3},"apoptotic process;ATP generation from poly-ADP-D-ribose;cellular response to amyloid-beta;cellular response to DNA damage stimulus;cellular response to insulin stimulus;cellular response to oxidative stress;cellular response to zinc ion;DNA damage response, detection of DNA damage;DNA ligation involved in DNA repair;DNA repair;double-strand break repair;double-strand break repair via homologous recombination;global genome nucleotide-excision repair;lagging strand elongation;macrophage differentiation;mitochondrial DNA metabolic process;mitochondrial DNA repair;mitochondrion organization;negative regulation of ATP biosynthetic process;negative regulation of telomere maintenance via telomere lengthening;negative regulation of transcription from RNA polymerase II promoter;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;peptidyl-serine ADP-ribosylation;positive regulation of cardiac muscle hypertrophy;positive regulation of intracellular estrogen receptor signaling pathway;positive regulation of mitochondrial depolarization;positive regulation of myofibroblast differentiation;positive regulation of neuron death;positive regulation of single strand break repair;positive regulation of SMAD protein import into nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription regulatory region DNA binding;protein ADP-ribosylation;protein autoprocessing;protein modification process;protein poly-ADP-ribosylation;regulation of catalytic activity;regulation of cellular protein localization;regulation of DNA methylation;regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;regulation of SMAD protein complex assembly;response to aldosterone;response to gamma radiation;signal transduction involved in regulation of gene expression;telomere maintenance;transcription from RNA polymerase II promoter;transforming growth factor beta receptor signaling pathway","DNA binding;DNA ligase (ATP) activity;enzyme binding;estrogen receptor binding;histone deacetylase binding;identical protein binding;NAD binding;NAD+ ADP-ribosyltransferase activity;protein ADP-ribosylase activity;protein kinase binding;protein N-terminus binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;R-SMAD binding;transcription factor binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;zinc ion binding","membrane;mitochondrion;nuclear chromosome, telomeric region;nuclear envelope;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;transcription factor complex","Apoptosis;Base excision repair;Necroptosis;NF-kappa B signaling pathway",null,null,10,10,10,"12.9","12.9","12.9","113.08",0,"53.818",601500000,52,"0.121476","0.902052","-0.270644","-0.355818","sp|P09874|PARP1_HUMAN","sp|P09874|PARP1_HUMAN",595,"P09874","PARP1_HUMAN","Poly [ADP-ribose] polymerase 1","ARP-1","PARP1"]
["16.2696","16.283","17.2844","15.8096",{"$nulls":3},"cell differentiation;chaperone-mediated protein folding;muscle organ development","cadherin binding;Hsp90 protein binding","cytosol;Golgi apparatus;nuclear speck;perinuclear region of cytoplasm",{"$nulls":3},3,3,3,"4.8","4.8","4.8","103.08",0,"4.7664",49178000,13,"0.125679","0.899262","-0.270726","-0.367138","sp|Q9H3U1|UN45A_HUMAN","sp|Q9H3U1|UN45A_HUMAN",2592,"Q9H3U1","UN45A_HUMAN","Protein unc-45 homolog A","nc-45A","UNC45A"]
["17.8931","17.6675","18.257","17.8453",{"$nulls":3},"ATP-dependent chromatin remodeling;beta-catenin-TCF complex assembly;blood coagulation;cellular response to oxidative stress;cellular response to tumor necrosis factor;chromatin organization;chromatin remodeling;circadian regulation of gene expression;embryonic digit morphogenesis;epidermal cell differentiation;eyelid development in camera-type eye;fungiform papilla formation;hair follicle placode formation;histone deacetylation;histone H3 deacetylation;histone H4 deacetylation;methylation-dependent chromatin silencing;negative regulation by host of viral transcription;negative regulation of androgen receptor signaling pathway;negative regulation of apoptotic process;negative regulation of canonical Wnt signaling pathway;negative regulation of cell proliferation;negative regulation of gene expression;negative regulation of insulin secretion;negative regulation of neuron apoptotic process;negative regulation of peptidyl-lysine acetylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;odontogenesis of dentin-containing tooth;positive regulation of cell proliferation;positive regulation of chemokine (C-X-C motif) ligand 2 production;positive regulation of interleukin-1 production;positive regulation of oligodendrocyte differentiation;positive regulation of receptor biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of tumor necrosis factor production;positive regulation of type B pancreatic cell apoptotic process;positive regulation of tyrosine phosphorylation of STAT protein;protein deacetylation;regulation of megakaryocyte differentiation;regulation of signal transduction by p53 class mediator;response to amphetamine;response to caffeine;response to drug;response to hyperoxia;response to lipopolysaccharide;transcription, DNA-templated;viral process","activating transcription factor binding;chromatin binding;core promoter binding;core promoter sequence-specific DNA binding;deacetylase activity;DNA binding transcription factor activity;enzyme binding;histone deacetylase activity;histone deacetylase binding;NAD-dependent histone deacetylase activity (H3-K14 specific);NF-kappaB binding;p53 binding;protein complex binding;protein deacetylase activity;protein N-terminus binding;repressing transcription factor binding;RNA polymerase II repressing transcription factor binding;RNA polymerase II transcription corepressor activity;RNA polymerase II transcription factor binding;transcription factor binding;transcription regulatory region DNA binding;transcription regulatory region sequence-specific DNA binding","chromatin;cytoplasm;cytosol;histone deacetylase complex;neuron projection;nuclear chromatin;nucleoplasm;nucleus;NuRD complex;perinuclear region of cytoplasm;protein complex;Sin3 complex","Alcoholism;Amphetamine addiction;Cell cycle;Chronic myeloid leukemia;Epstein-Barr virus infection;Human papillomavirus infection;Huntington disease;Longevity regulating pathway - multiple species;MicroRNAs in cancer;Notch signaling pathway;Pathways in cancer;Thyroid hormone signaling pathway;Transcriptional misregulation in cancer;Viral carcinogenesis",null,null,3,1,1,"8.9","3.9","3.9","55.102","0.0003873","3.0857",61354000,2,"0.434383","0.575604","-0.270863","-1.15391","sp|Q13547|HDAC1_HUMAN","sp|Q13547|HDAC1_HUMAN",1569,"Q13547","HDAC1_HUMAN","Histone deacetylase 1","D1","HDAC1"]
["15.2934","15.2307","16.0931","14.9728",{"$nulls":3},"epoxygenase P450 pathway","arachidonic acid epoxygenase activity;aromatase activity;heme binding;iron ion binding;retinoic acid 4-hydroxylase activity;steroid hydroxylase activity","endoplasmic reticulum;endoplasmic reticulum membrane;organelle membrane","Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Retinol metabolism",null,null,1,1,1,3,3,3,"55.816","0.0075658","1.7518",14572000,5,"0.169488","0.85126","-0.270897","-0.482863","sp|Q96SQ9|CP2S1_HUMAN","sp|Q96SQ9|CP2S1_HUMAN",2356,"Q96SQ9","CP2S1_HUMAN","Cytochrome P450 2S1",null,"CYP2S1"]
["20.8715","20.7278","21.2978","20.8438",{"$nulls":3},"actin filament capping;axon guidance;common-partner SMAD protein phosphorylation;ER to Golgi vesicle-mediated transport;Golgi to plasma membrane protein transport;MAPK cascade;membrane assembly;mitotic cytokinesis;plasma membrane organization;positive regulation of interleukin-2 secretion;positive regulation of protein localization to plasma membrane;protein localization to plasma membrane;regulation of protein localization to plasma membrane;SMAD protein import into nucleus","actin binding;ankyrin binding;cadherin binding;calmodulin binding;GTPase binding;phospholipid binding;protein complex binding;Ras guanyl-nucleotide exchange factor activity;RNA binding;structural constituent of cytoskeleton","axolemma;cuticular plate;cytoplasm;cytosol;extracellular exosome;M band;nucleolus;postsynaptic density;protein complex;spectrin;spectrin-associated cytoskeleton",{"$nulls":3},49,49,46,"28.3","28.3","26.9","274.61",0,"323.31",2986900000,232,"0.428455","0.584743","-0.271109","-1.13866","sp|Q01082|SPTB2_HUMAN;tr|A0A087WUZ3|A0A087WUZ3_HUMAN;tr|F8W6C1|F8W6C1_HUMAN;tr|A4QPE4|A4QPE4_HUMAN;tr|E9PJZ2|E9PJZ2_HUMAN","sp|Q01082|SPTB2_HUMAN;tr|A0A087WUZ3|A0A087WUZ3_HUMAN",1412,"Q01082","SPTB2_HUMAN","Spectrin beta chain, non-erythrocytic 1",null,"SPTBN1"]
["18.0479","16.7279","18.6272","16.6913",{"$nulls":3},"cortical actin cytoskeleton organization","actin binding;structural molecule activity","cytoskeleton",{"$nulls":3},3,3,3,"8.2","8.2","8.2","69.889",0,"4.1682",46878000,7,"0.0765657","0.930512","-0.271374","-0.231629","tr|Q4VB86|Q4VB86_HUMAN;sp|P11171|41_HUMAN","tr|Q4VB86|Q4VB86_HUMAN;sp|P11171|41_HUMAN",620,"Q4VB86","Q4VB86_HUMAN"]
["15.9432","16.1704","17.2351","15.4243",{"$nulls":9},1,1,1,"5.3","5.3","5.3","29.411","0.0011253","2.8038",14179000,2,"0.100676","0.914482","-0.272908","-0.299082","sp|Q6PID6|TTC33_HUMAN","sp|Q6PID6|TTC33_HUMAN",1895,"Q6PID6","TTC33_HUMAN","Tetratricopeptide repeat protein 33","PR repeat protein 33","TTC33"]
["26.74","26.7285","27.2464","26.7679",{"$nulls":3},"canonical glycolysis;gluconeogenesis;glyceraldehyde-3-phosphate biosynthetic process;glycerol catabolic process;glycolytic process;multicellular organism development;pentose-phosphate shunt","triose-phosphate isomerase activity;ubiquitin protein ligase binding","cytosol;extracellular exosome;extracellular space;nucleus","Biosynthesis of amino acids;Carbon metabolism;Fructose and mannose metabolism;Glycolysis / Gluconeogenesis;Inositol phosphate metabolism;Metabolic pathways",null,null,15,15,15,"65.4","65.4","65.4","30.791",0,"323.31",22237000000,197,"0.429121","0.583851","-0.272956","-1.14037","sp|P60174|TPIS_HUMAN;tr|U3KPZ0|U3KPZ0_HUMAN;tr|U3KQF3|U3KQF3_HUMAN;tr|U3KPS5|U3KPS5_HUMAN","sp|P60174|TPIS_HUMAN",1234,"P60174","TPIS_HUMAN","Triosephosphate isomerase","IM","TPI1"]
["17.0882","16.674","17.2318","17.0767",{"$nulls":3},"cell-cell adhesion;fertilization;Sertoli cell development;spermatid development","RNA binding","acrosomal vesicle;cytosol;Golgi apparatus;Golgi membrane;integral component of membrane;membrane;vesicle membrane",{"$nulls":3},4,4,4,"4.5","4.5","4.5","131.85",0,"12.535",59277000,12,"0.465676","0.538134","-0.273156","-1.23499","sp|Q9Y2H6|FND3A_HUMAN;tr|G5E9X3|G5E9X3_HUMAN;tr|H7C507|H7C507_HUMAN;tr|A0A087X1M6|A0A087X1M6_HUMAN","sp|Q9Y2H6|FND3A_HUMAN;tr|G5E9X3|G5E9X3_HUMAN",2950,"Q9Y2H6","FND3A_HUMAN","Fibronectin type-III domain-containing protein 3A",null,"FNDC3A"]
["21.0767","21.1186","21.4238","21.32",{"$nulls":3},"learning;locomotory behavior;negative regulation of Arp2/3 complex-mediated actin nucleation;nervous system development;protein phosphorylation;signal transduction","actin binding;Arp2/3 complex binding;enzyme activator activity;growth factor activity;protein kinase inhibitor activity;signal transducer activity","intracellular",{"$nulls":3},4,4,2,38,38,"23.9","16.713",0,"7.4817",160060000,11,"1.40607","0.330427","-0.274223","-4.89718","sp|P60983|GMFB_HUMAN;tr|G3V4P8|G3V4P8_HUMAN","sp|P60983|GMFB_HUMAN;tr|G3V4P8|G3V4P8_HUMAN",1248,"P60983","GMFB_HUMAN","Glia maturation factor beta","MF-beta","GMFB"]
["15.5867","15.0152","15.5618","15.5886",{"$nulls":3},"muscle organ development;positive regulation of striated muscle tissue development;positive regulation of transcription from RNA polymerase II promoter;smooth muscle cell differentiation","cadherin binding;RNA polymerase II transcription coactivator activity;transcription coactivator activity","nucleus",{"$nulls":3},1,1,1,"1.7","1.7","1.7","118.13","0.00039047","3.166",12911000,5,"0.357662","0.674457","-0.274251","-0.958713","sp|Q9ULH7|MKL2_HUMAN","sp|Q9ULH7|MKL2_HUMAN",2893,"Q9ULH7","MKL2_HUMAN","MKL/myocardin-like protein 2",null,"MKL2"]
["19.9054","19.8686","20.4551","19.8675",{"$nulls":3},"cell proliferation;ER to Golgi vesicle-mediated transport;Golgi to vacuole transport;intra-Golgi vesicle-mediated transport;membrane fusion;platelet degranulation;protein targeting to vacuole;regulation of protein localization to plasma membrane;retrograde transport, endosome to Golgi;vesicle docking involved in exocytosis;vesicle fusion with Golgi apparatus;vesicle-mediated transport","chloride channel inhibitor activity;SNAP receptor activity;SNARE binding","cytosol;early endosome membrane;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;extracellular region;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;late endosome membrane;lysosomal membrane;neuronal cell body;perinuclear region of cytoplasm;platelet alpha granule lumen;recycling endosome;recycling endosome membrane;SNARE complex;synaptic vesicle;vesicle","SNARE interactions in vesicular transport",null,null,4,4,3,22,22,"15.1","26.688",0,"14.045",128800000,12,"0.346935","0.687584","-0.274303","-0.931705","sp|Q9UEU0|VTI1B_HUMAN;tr|H0YJL5|H0YJL5_HUMAN;tr|H0YJJ5|H0YJJ5_HUMAN","sp|Q9UEU0|VTI1B_HUMAN;tr|H0YJL5|H0YJL5_HUMAN;tr|H0YJJ5|H0YJJ5_HUMAN",2819,"Q9UEU0","VTI1B_HUMAN","Vesicle transport through interaction with t-SNAREs homolog 1B",null,"VTI1B"]
["24.0627","24.1227","24.5489","24.1855",{"$nulls":3},"cellular response to testosterone stimulus;establishment of endothelial barrier;establishment of epithelial cell apical/basal polarity;gland morphogenesis;immunological synapse formation;interleukin-12-mediated signaling pathway;leukocyte cell-cell adhesion;leukocyte migration;membrane to membrane docking;movement of cell or subcellular component;positive regulation of cellular protein catabolic process;positive regulation of early endosome to late endosome transport;positive regulation of gene expression;positive regulation of podosome assembly;positive regulation of protein localization to early endosome;regulation of cell shape;regulation of cell size;regulation of lymphocyte migration;regulation of organelle assembly;T cell aggregation;T cell migration;T cell proliferation","actin binding;cell adhesion molecule binding;double-stranded RNA binding;enzyme binding;protein kinase binding;receptor binding;structural constituent of cytoskeleton","apical part of cell;apical plasma membrane;basolateral plasma membrane;blood microparticle;cell periphery;cell surface;cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular space;filopodium;focal adhesion;invadopodium;microvillus;microvillus membrane;myelin sheath;nucleus;perinuclear region of cytoplasm;plasma membrane;pseudopodium;uropod;vesicle","Leukocyte transendothelial migration;Measles;Proteoglycans in cancer;Regulation of actin cytoskeleton;Tight junction",null,null,26,26,21,"45.9","45.9","37.3","67.819",0,"304.03",6171700000,219,"0.561227","0.472014","-0.274463","-1.49018","sp|P26038|MOES_HUMAN;tr|V9GZ54|V9GZ54_HUMAN;tr|E9PNP4|E9PNP4_HUMAN","sp|P26038|MOES_HUMAN",805,"P26038","MOES_HUMAN","Moesin {ECO:0000303|PubMed:1924289}",null,"MSN"]
["17.9685","17.8132","18.2192","18.1124",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding;transferase activity","nucleoplasm",{"$nulls":3},2,2,2,"5.8","5.8","5.8","61.687",0,"17.718",67070000,11,"0.999278","0.296057","-0.274972","-2.91715","sp|Q8IU81|I2BP1_HUMAN","sp|Q8IU81|I2BP1_HUMAN",2005,"Q8IU81","I2BP1_HUMAN","Interferon regulatory factor 2-binding protein 1","RF-2-binding protein 1;RF-2BP1","IRF2BP1"]
["16.7765","17.2911","17.151","17.4706",{"$nulls":4},"DNA binding","cytosol;nucleoplasm",{"$nulls":3},6,6,6,"3.1","3.1","3.1","258.98",0,"36.546",146050000,16,"0.340016","0.695688","-0.276952","-0.914309","tr|A0A088AWL3|A0A088AWL3_HUMAN;sp|O75376|NCOR1_HUMAN;tr|E7EVK1|E7EVK1_HUMAN;sp|Q9H4R4|CT191_HUMAN;tr|E7EVU5|E7EVU5_HUMAN;tr|E7EW50|E7EW50_HUMAN;tr|J3KS51|J3KS51_HUMAN","tr|A0A088AWL3|A0A088AWL3_HUMAN;sp|O75376|NCOR1_HUMAN",336,"A0A088AWL3","A0A088AWL3_HUMAN",null,null,"NCOR1"]
["16.1965","15.6642","17.0382","15.3772",{"$nulls":3},"intracellular signal transduction;regulation of Rho protein signal transduction","Rho guanyl-nucleotide exchange factor activity","cytoplasm",{"$nulls":3},5,5,5,8,8,8,"161.91",0,"11.888",57769000,9,"0.107565","0.911861","-0.27734","-0.31801","tr|E9PMR6|E9PMR6_HUMAN;sp|Q9NZN5|ARHGC_HUMAN","tr|E9PMR6|E9PMR6_HUMAN;sp|Q9NZN5|ARHGC_HUMAN",2762,"E9PMR6","E9PMR6_HUMAN",null,null,"ARHGEF12"]
["17.4379","17.672","18.0061","17.66",{"$nulls":3},"brain development;fatty acid biosynthetic process;long-chain fatty acid import;long-chain fatty-acyl-CoA biosynthetic process;positive regulation of Golgi to plasma membrane protein transport;positive regulation of phosphatidylcholine biosynthetic process;positive regulation of secretion;response to nutrient;response to organic cyclic compound;very-low-density lipoprotein particle assembly","ATP binding;decanoate--CoA ligase activity;long-chain fatty acid-CoA ligase activity;protein domain specific binding;protein kinase binding","endoplasmic reticulum;endoplasmic reticulum membrane;Golgi apparatus;integral component of membrane;lipid droplet;membrane;mitochondrial outer membrane;perinuclear region of cytoplasm;peroxisomal membrane","Adipocytokine signaling pathway;Fatty acid biosynthesis;Fatty acid degradation;Fatty acid metabolism;Ferroptosis;Metabolic pathways;Peroxisome;PPAR signaling pathway;Thermogenesis",null,null,5,3,3,"9.6","5.6","5.6","80.419",0,"13.313",129450000,15,"0.502208","0.513571","-0.27809","-1.33106","sp|O95573|ACSL3_HUMAN","sp|O95573|ACSL3_HUMAN",441,"O95573","ACSL3_HUMAN","Long-chain-fatty-acid--CoA ligase 3",null,"ACSL3"]
["19.7364","19.7273","20.2107","19.8101",{"$nulls":3},"cell division;DNA repair;interaction with symbiont;meiotic cell cycle;mitotic cell cycle;negative regulation of DNA endoreduplication;positive regulation by host of viral release from host cell;regulation of DNA replication;regulation of mitotic spindle assembly;sister chromatid cohesion;stem cell population maintenance","ATP binding;beta-tubulin binding;chromatin binding;dynein complex binding;mediator complex binding;microtubule motor activity;protein heterodimerization activity","basement membrane;chromatin;chromosome;chromosome, centromeric region;cohesin complex;cytosol;intracellular;lateral element;meiotic cohesin complex;mitotic spindle pole;nuclear matrix;nuclear meiotic cohesin complex;nucleoplasm;nucleus","Cell cycle;Oocyte meiosis",null,null,13,13,13,"14.1","14.1","14.1","141.54",0,"72.103",513890000,62,"0.524384","0.502998","-0.27857","-1.39024","sp|Q9UQE7|SMC3_HUMAN","sp|Q9UQE7|SMC3_HUMAN",2932,"Q9UQE7","SMC3_HUMAN","Structural maintenance of chromosomes protein 3","MC protein 3;MC-3","SMC3"]
["20.5175","20.6543","20.9543","20.7749",{"$nulls":3},"positive regulation of gene expression","cadherin binding;RNA binding","cytoplasm;nucleus",{"$nulls":3},13,13,13,"21.6","21.6","21.6","117.11",0,"130.25",556890000,63,"0.879038","0.301681","-0.278724","-2.4707","sp|Q5T6F2|UBAP2_HUMAN;tr|A2A305|A2A305_HUMAN;tr|F5H2U4|F5H2U4_HUMAN;tr|Q5JV08|Q5JV08_HUMAN","sp|Q5T6F2|UBAP2_HUMAN",1835,"Q5T6F2","UBAP2_HUMAN","Ubiquitin-associated protein 2","BAP-2","UBAP2"]
["21.4185","21.2685","21.931","21.3143",{"$nulls":3},"axon guidance;cellular response to interferon-gamma;centrosome localization;cytoplasm organization;cytoskeleton-dependent intracellular transport;hippocampus development;microtubule-based movement;plus-end-directed vesicle transport along microtubule;positive regulation of insulin secretion involved in cellular response to glucose stimulus;positive regulation of intracellular protein transport;positive regulation of potassium ion transport;positive regulation of protein localization to plasma membrane;positive regulation of synaptic transmission, GABAergic;positive regulation of vesicle fusion;positive regulation of voltage-gated sodium channel activity;regulation of membrane potential;stress granule disassembly;vesicle transport along microtubule","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;cadherin binding;identical protein binding;JUN kinase binding;microtubule binding;microtubule lateral binding;microtubule motor activity","axonal growth cone;ciliary rootlet;cytosol;kinesin complex;membrane;microtubule;microtubule organizing center;perinuclear region of cytoplasm;phagocytic vesicle;vesicle","Dopaminergic synapse;Endocytosis",null,null,25,25,22,"36.3","36.3","32.6","109.68",0,"323.31",1942600000,118,"0.326223","0.705435","-0.279148","-0.879673","sp|P33176|KINH_HUMAN;sp|O60282|KIF5C_HUMAN;tr|A0A0G2JMZ6|A0A0G2JMZ6_HUMAN","sp|P33176|KINH_HUMAN",908,"P33176","KINH_HUMAN","Kinesin-1 heavy chain",null,"KIF5B"]
["19.9256","19.6788","20.5116","19.6528",{"$nulls":9},2,2,2,"16.4","16.4","16.4","16.043",0,"23.548",83615000,13,"0.225601","0.796572","-0.280006","-0.62673","tr|B7Z415|B7Z415_HUMAN;tr|D6RGG7|D6RGG7_HUMAN;sp|P09417|DHPR_HUMAN;tr|D6RHJ7|D6RHJ7_HUMAN;tr|H0Y8F7|H0Y8F7_HUMAN","tr|B7Z415|B7Z415_HUMAN;tr|D6RGG7|D6RGG7_HUMAN;sp|P09417|DHPR_HUMAN;tr|D6RHJ7|D6RHJ7_HUMAN;tr|H0Y8F7|H0Y8F7_HUMAN",582,"B7Z415","B7Z415_HUMAN"]
["21.8959","22.1837","22.5239","22.1171",{"$nulls":3},"ion transport;macroautophagy;protein import into mitochondrial matrix;protein targeting to mitochondrion","porin activity;protein channel activity;protein transmembrane transporter activity","cytosol;extracellular exosome;integral component of membrane;integral component of mitochondrial outer membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrial outer membrane translocase complex;mitochondrion;pore complex","Amyotrophic lateral sclerosis (ALS)",null,null,5,5,5,"24.1","24.1","24.1","37.893",0,"121.08",434000000,32,"0.423852","0.589914","-0.280746","-1.12685","sp|O96008|TOM40_HUMAN;tr|K7EJ57|K7EJ57_HUMAN;tr|K7EKG4|K7EKG4_HUMAN","sp|O96008|TOM40_HUMAN;tr|K7EJ57|K7EJ57_HUMAN",460,"O96008","TOM40_HUMAN","Mitochondrial import receptor subunit TOM40 homolog",null,"TOMM40"]
["21.2663","21.09","21.8373","21.0808",{"$nulls":3},"chaperone-mediated protein folding","FK506 binding;peptidyl-prolyl cis-trans isomerase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome",{"$nulls":3},2,2,2,"28.2","28.2","28.2","15.649",0,"19.487",176110000,7,"0.263863","0.75794","-0.280876","-0.723249","sp|P26885|FKBP2_HUMAN;tr|F5H0N4|F5H0N4_HUMAN","sp|P26885|FKBP2_HUMAN;tr|F5H0N4|F5H0N4_HUMAN",818,"P26885","FKBP2_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP2","PIase FKBP2","FKBP2"]
["22.4242","22.2073","23.3192","21.8744",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;calcium ion regulated exocytosis;cellular response to interferon-gamma;exocytosis;Golgi to plasma membrane protein transport;membrane fusion;membrane organization;negative regulation of secretion by cell;positive regulation of receptor recycling;protein complex assembly;retrograde transport, endosome to Golgi;SNARE complex assembly;substrate adhesion-dependent cell spreading;vesicle docking involved in exocytosis;vesicle fusion;vesicle-mediated transport","SNAP receptor activity;SNARE binding;syntaxin-1 binding","apical plasma membrane;cell junction;cell surface;clathrin-coated vesicle;clathrin-coated vesicle membrane;cytosol;integral component of membrane;intracellular;intracellular membrane-bounded organelle;neuron projection;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;recycling endosome;recycling endosome membrane;secretory granule;SNARE complex;synapse;trans-Golgi network membrane;transport vesicle","Phagosome;SNARE interactions in vesicular transport",null,null,3,3,3,52,52,52,"11.309",0,"35.143",293960000,15,"0.132257","0.898128","-0.281069","-0.384772","sp|Q15836|VAMP3_HUMAN;tr|K7ENK9|K7ENK9_HUMAN;tr|K7EKX0|K7EKX0_HUMAN;tr|J3QRU4|J3QRU4_HUMAN;sp|P63027|VAMP2_HUMAN;tr|F8WCA0|F8WCA0_HUMAN;tr|L7N2F9|L7N2F9_HUMAN","sp|Q15836|VAMP3_HUMAN",1727,"Q15836","VAMP3_HUMAN","Vesicle-associated membrane protein 3","AMP-3","VAMP3"]
["20.2235","20.2295","20.5945","20.4223",{"$nulls":3},"cellular metabolic process",{"$nulls":5},3,3,3,"10.8","10.8","10.8","57.495",0,"31.163",313690000,25,"1.08602","0.307456","-0.281899","-3.27288","tr|A0A087WTA5|A0A087WTA5_HUMAN;sp|Q9UI10|EI2BD_HUMAN;tr|E7ERK9|E7ERK9_HUMAN;tr|A0A087WW69|A0A087WW69_HUMAN;tr|H7C2L8|H7C2L8_HUMAN;tr|F8W8L6|F8W8L6_HUMAN","tr|A0A087WTA5|A0A087WTA5_HUMAN;sp|Q9UI10|EI2BD_HUMAN;tr|E7ERK9|E7ERK9_HUMAN;tr|A0A087WW69|A0A087WW69_HUMAN",2844,"A0A087WTA5","A0A087WTA5_HUMAN",null,null,"EIF2B4"]
["16.9024","16.5027","17.3487","16.6203",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;autophagosome maturation;cellular protein complex localization;endosome to lysosome transport;intracellular protein transport;late endosome to lysosome transport;lysosomal lumen acidification;lysosome localization;melanosome organization;negative regulation of neuron projection development;neuron projection development;neurotransmitter secretion;positive regulation of late endosome to lysosome transport;protein maturation;regulation of protein binding;retrograde axonal transport;synaptic vesicle exocytosis;synaptic vesicle fusion to presynaptic active zone membrane;synaptic vesicle maturation;synaptic vesicle transport;terminal button organization;viral process","SNARE binding","axon cytoplasm;BLOC-1 complex;BORC complex;cell junction;Golgi membrane;lysosomal membrane;perinuclear region of cytoplasm;secretory granule;synapse;synaptic vesicle;synaptic vesicle membrane",{"$nulls":3},1,1,1,"15.4","15.4","15.4","14.874",0,"3.7768",8258700,3,"0.246124","0.782098","-0.281921","-0.678603","sp|O95295|SNAPN_HUMAN","sp|O95295|SNAPN_HUMAN",423,"O95295","SNAPN_HUMAN","SNARE-associated protein Snapin",null,"SNAPIN"]
["21.5696","21.3226","22.0473","21.4089",{"$nulls":3},"angiogenesis;apoptotic process;cell adhesion;cell-cell signaling;chemotaxis;defense response to virus;glucose metabolic process;inflammatory response;leukocyte migration;negative regulation of endothelial cell proliferation;response to wounding;signal transduction;tRNA aminoacylation for protein translation","cytokine activity;GTPase binding;protein homodimerization activity;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cell surface;cytosol;endoplasmic reticulum;extracellular space;Golgi apparatus;membrane;methionyl glutamyl tRNA synthetase complex;nucleus;transport vesicle",{"$nulls":3},7,7,7,"36.5","36.5","36.5","34.352",0,"21.294",511810000,42,"0.304004","0.723368","-0.282028","-0.823952","sp|Q12904|AIMP1_HUMAN;tr|D6R937|D6R937_HUMAN","sp|Q12904|AIMP1_HUMAN;tr|D6R937|D6R937_HUMAN",1503,"Q12904","AIMP1_HUMAN","Aminoacyl tRNA synthase complex-interacting multifunctional protein 1",null,"AIMP1"]
["17.9425","17.6206","17.5958","18.5336",{"$nulls":3},"'de novo' CTP biosynthetic process;glutamine metabolic process;nucleobase-containing small molecule interconversion;pyrimidine nucleotide metabolic process","ATP binding;CTP synthase activity","cytosol;mitochondrion","Metabolic pathways;Pyrimidine metabolism",null,null,4,2,2,"9.6","5.1","5.1","65.677",0,"5.1187",89881000,6,"0.203745","0.817812","-0.283129","-0.57112","sp|Q9NRF8|PYRG2_HUMAN","sp|Q9NRF8|PYRG2_HUMAN",2682,"Q9NRF8","PYRG2_HUMAN","CTP synthase 2",null,"CTPS2"]
["20.6146","20.3021","21.1247","20.3587",{"$nulls":3},"actin cytoskeleton reorganization;activation of JUN kinase activity;activation of signaling protein activity involved in unfolded protein response;endoplasmic reticulum unfolded protein response;insulin receptor signaling pathway;IRE1-mediated unfolded protein response;JAK-STAT cascade involved in growth hormone signaling pathway;negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;negative regulation of ERK1 and ERK2 cascade;negative regulation of insulin receptor signaling pathway;negative regulation of MAP kinase activity;negative regulation of PERK-mediated unfolded protein response;negative regulation of signal transduction;negative regulation of vascular endothelial growth factor receptor signaling pathway;peptidyl-tyrosine dephosphorylation;peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;platelet-derived growth factor receptor-beta signaling pathway;positive regulation of IRE1-mediated unfolded protein response;positive regulation of protein tyrosine kinase activity;positive regulation of receptor catabolic process;protein dephosphorylation;regulation of endocytosis;regulation of hepatocyte growth factor receptor signaling pathway;regulation of intracellular protein transport;regulation of signal transduction;regulation of type I interferon-mediated signaling pathway","cadherin binding;enzyme binding;ephrin receptor binding;insulin receptor binding;protein kinase binding;protein phosphatase 2A binding;protein tyrosine phosphatase activity;receptor tyrosine kinase binding;RNA binding;zinc ion binding","cytoplasmic side of endoplasmic reticulum membrane;cytosol;early endosome;endoplasmic reticulum;sorting endosome","Adherens junction;Insulin resistance;Insulin signaling pathway",null,null,11,11,11,28,28,28,"49.966",0,"52.807",655100000,41,"0.248719","0.778003","-0.283399","-0.685143","sp|P18031|PTN1_HUMAN;tr|B4DSN5|B4DSN5_HUMAN","sp|P18031|PTN1_HUMAN;tr|B4DSN5|B4DSN5_HUMAN",716,"P18031","PTN1_HUMAN","Tyrosine-protein phosphatase non-receptor type 1",null,"PTPN1"]
["17.8478",1,"18.4151",1,{"$nulls":5},"nucleus",{"$nulls":3},1,1,1,"5.8","5.8","5.8","25.977",0,"10.372",20792000,6,"0.00724921","0.986503","-0.283662","-0.0234132","sp|Q8IYL3|CA174_HUMAN","sp|Q8IYL3|CA174_HUMAN",2025,"Q8IYL3","CA174_HUMAN","UPF0688 protein C1orf174",null,"C1orf174"]
["16.7592","16.9862","17.0806","17.2324",{"$nulls":3},"proteolysis","serine-type endopeptidase activity;serine-type exopeptidase activity;serine-type peptidase activity","cytoplasm;cytosol;membrane;nucleus","Renin-angiotensin system",null,null,5,5,5,"10.7","10.7","10.7","80.699",0,"13.134",67271000,19,"0.761427","0.338476","-0.28382","-2.07864","sp|P48147|PPCE_HUMAN","sp|P48147|PPCE_HUMAN",1050,"P48147","PPCE_HUMAN","Prolyl endopeptidase","E","PREP"]
["23.4809","23.4192","23.8334","23.6346",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of inflammatory response to antigenic stimulus;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","lipopolysaccharide binding;threonine-type endopeptidase activity","cytosol;extracellular exosome;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex","Proteasome",null,null,7,7,7,"45.5","45.5","45.5","29.204",0,"124.01",1320900000,44,"0.950039","0.295713","-0.28393","-2.72819","sp|P28070|PSB4_HUMAN","sp|P28070|PSB4_HUMAN",833,"P28070","PSB4_HUMAN","Proteasome subunit beta type-4",null,"PSMB4"]
["18.0332","16.8305","18.4351","16.9966",{"$nulls":3},"cell division;mitotic nuclear envelope disassembly","ATP binding;metal ion binding;protein kinase binding;protein serine/threonine kinase activity","cytosol;nucleus",{"$nulls":3},5,5,5,"7.4","7.4","7.4","107.17",0,"8.4015",104780000,10,"0.102081","0.913696","-0.284036","-0.302955","sp|Q8TD19|NEK9_HUMAN","sp|Q8TD19|NEK9_HUMAN",2119,"Q8TD19","NEK9_HUMAN","Serine/threonine-protein kinase Nek9",null,"NEK9"]
["17.7079","18.1253","18.5761","17.8284",{"$nulls":3},"DNA damage response, detection of DNA damage;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleolus","Ribosome",null,null,4,4,4,"12.1","12.1","12.1","45.834",0,"3.6817",78121000,3,"0.241595","0.785319","-0.28565","-0.66718","sp|P82933|RT09_HUMAN","sp|P82933|RT09_HUMAN",1387,"P82933","RT09_HUMAN","28S ribosomal protein S9, mitochondrial","9mt;RP-S9","MRPS9"]
["19.8601","19.6636","20.0443","20.0509",{"$nulls":3},"carbohydrate metabolic process;ethanol catabolic process;ethanol oxidation","aldehyde dehydrogenase (NAD) activity;NAD binding","intracellular membrane-bounded organelle;mitochondrial matrix;mitochondrion;nucleoplasm","Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Fatty acid degradation;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Lysine degradation;Metabolic pathways;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,6,5,5,"14.3","12.6","12.6","57.206",0,"9.5173",182660000,16,"0.996349","0.295288","-0.285755","-2.90565","sp|P30837|AL1B1_HUMAN","sp|P30837|AL1B1_HUMAN",878,"P30837","AL1B1_HUMAN","Aldehyde dehydrogenase X, mitochondrial",null,"ALDH1B1"]
["22.5966","22.3393","22.9481","22.5608",{"$nulls":3},"translational initiation","translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex","RNA transport",null,null,9,9,9,45,45,45,"29.062",0,"111.06",872470000,44,"0.464597","0.538682","-0.286477","-1.23217","sp|O75822|EIF3J_HUMAN;tr|H0YGJ7|H0YGJ7_HUMAN;tr|H0YLP3|H0YLP3_HUMAN","sp|O75822|EIF3J_HUMAN",368,"O75822","EIF3J_HUMAN","Eukaryotic translation initiation factor 3 subunit J {ECO:0000255|HAMAP-Rule:MF_03009}","IF3j {ECO:0000255|HAMAP-Rule:MF_03009}","EIF3J"]
["20.685","20.5308","20.8976","20.8917",{"$nulls":3},"rRNA modification;tRNA modification","RNA binding","nucleoplasm",{"$nulls":3},7,7,7,"24.9","24.9","24.9","39.315",0,"94.677",324100000,37,"1.18448","0.320945","-0.286737","-3.7161","sp|Q9NXG2|THUM1_HUMAN;tr|H3BNW0|H3BNW0_HUMAN","sp|Q9NXG2|THUM1_HUMAN",2739,"Q9NXG2","THUM1_HUMAN","THUMP domain-containing protein 1",null,"THUMPD1"]
["15.8705","15.9588","16.6558","15.7479",{"$nulls":3},"apical junction assembly;apoptotic process;cell adhesion;cell cycle;cell division;epithelial cell migration;intracellular signal transduction;peptidyl-serine phosphorylation;positive regulation of cytokinesis;positive regulation of mitotic cell cycle;positive regulation of viral genome replication;protein phosphorylation;regulation of cell motility;regulation of transcription, DNA-templated;signal transduction;transcription, DNA-templated","ATP binding;cadherin binding;GTP-Rho binding;histone deacetylase binding;kinase activity;protein kinase activity;protein kinase C activity;protein serine/threonine kinase activity;RNA binding;RNA polymerase binding","apical junction complex;cleavage furrow;cytoplasm;cytoskeleton;cytosol;lamellipodium;membrane;midbody;nucleus;perinuclear region of cytoplasm;protein complex","PI3K-Akt signaling pathway;Salmonella infection;Yersinia infection",null,null,2,2,2,"4.3","4.3","4.3","112.03","0.0010803","2.4504",43374000,10,"0.226776","0.796417","-0.287189","-0.629708","sp|Q16513|PKN2_HUMAN;tr|B1AL79|B1AL79_HUMAN","sp|Q16513|PKN2_HUMAN;tr|B1AL79|B1AL79_HUMAN",1737,"Q16513","PKN2_HUMAN","Serine/threonine-protein kinase N2",null,"PKN2"]
["20.4248","20.0009","21.055","19.9455",{"$nulls":3},"aldehyde catabolic process;cellular aldehyde metabolic process;D-glucuronate catabolic process;glucose metabolic process;glucuronate catabolic process to xylulose 5-phosphate;glutathione derivative biosynthetic process;L-ascorbic acid biosynthetic process","alditol:NADP+ 1-oxidoreductase activity;aldo-keto reductase (NADP) activity;electron transfer activity;L-glucuronate reductase activity","apical plasma membrane;cytosol;extracellular exosome;extracellular space","Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways;Pentose and glucuronate interconversions",null,null,6,6,6,"25.8","25.8","25.8","36.573",0,"11.87",279530000,22,"0.169909","0.85113","-0.2874","-0.483955","sp|P14550|AK1A1_HUMAN;tr|Q5T621|Q5T621_HUMAN;tr|V9GYG2|V9GYG2_HUMAN;tr|V9GYP9|V9GYP9_HUMAN","sp|P14550|AK1A1_HUMAN",669,"P14550","AK1A1_HUMAN","Alcohol dehydrogenase [NADP(+)]",null,"AKR1A1"]
["20.7257","20.2557","21.031","20.5256",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;mRNA splicing, via spliceosome","Ral GTPase binding;RNA binding;U6 snRNA binding","catalytic step 2 spliceosome;cytosol;Lsm1-7-Pat1 complex;nucleoplasm;P-body;precatalytic spliceosome;U4/U6 x U5 tri-snRNP complex;U6 snRNP","RNA degradation;Spliceosome",null,null,2,2,2,"31.6","31.6","31.6","10.834",0,"23.44",87602000,12,"0.307846","0.718176","-0.287639","-0.833583","sp|Q9Y333|LSM2_HUMAN","sp|Q9Y333|LSM2_HUMAN",2972,"Q9Y333","LSM2_HUMAN","U6 snRNA-associated Sm-like protein LSm2",null,"LSM2"]
["22.8151","22.6622","23.1963","22.8569",{"$nulls":3},"mRNA processing","RNA binding","nucleus",{"$nulls":3},12,12,11,"43.5","43.5","42.1","56.51",0,"323.31",1131300000,118,"0.581832","0.453102","-0.28796","-1.54703","tr|A6NLN1|A6NLN1_HUMAN;sp|P26599|PTBP1_HUMAN;tr|A0A0D9SF20|A0A0D9SF20_HUMAN;tr|K7EK45|K7EK45_HUMAN;tr|K7EKJ7|K7EKJ7_HUMAN;tr|K7ES59|K7ES59_HUMAN;tr|A0A087WU68|A0A087WU68_HUMAN;tr|A0A087WUW5|A0A087WUW5_HUMAN;tr|K7ELW5|K7ELW5_HUMAN","tr|A6NLN1|A6NLN1_HUMAN;sp|P26599|PTBP1_HUMAN",814,"A6NLN1","A6NLN1_HUMAN"]
["21.1203","20.9106","21.65","20.9569",{"$nulls":3},"actin filament capping;axon guidance;ER to Golgi vesicle-mediated transport;MAPK cascade;neutrophil degranulation","actin binding;cadherin binding;calcium ion binding;calmodulin binding;Ras guanyl-nucleotide exchange factor activity;structural constituent of cytoskeleton","cytosol;extracellular exosome;extracellular region;extracellular vesicle;intracellular membrane-bounded organelle;membrane;microtubule cytoskeleton;specific granule lumen;spectrin;tertiary granule lumen","Apoptosis",null,null,54,54,54,"30.1","30.1","30.1","284.54",0,"323.31",3741500000,232,"0.292629","0.739133","-0.287994","-0.795437","sp|Q13813|SPTN1_HUMAN;tr|A0A0D9SGF6|A0A0D9SGF6_HUMAN;tr|A0A0D9SF54|A0A0D9SF54_HUMAN;tr|A0A0D9SFF6|A0A0D9SFF6_HUMAN;tr|A0A0D9SFH4|A0A0D9SFH4_HUMAN","sp|Q13813|SPTN1_HUMAN;tr|A0A0D9SGF6|A0A0D9SGF6_HUMAN;tr|A0A0D9SF54|A0A0D9SF54_HUMAN",1587,"Q13813","SPTN1_HUMAN","Spectrin alpha chain, non-erythrocytic 1",null,"SPTAN1"]
["16.7","17.0775","17.6136","16.7403",{"$nulls":3},"negative regulation of DNA recombination at telomere;negative regulation of protein phosphorylation;negative regulation of telomere maintenance;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of NIK/NF-kappaB signaling;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein acetylation;protection from non-homologous end joining at telomere;protein localization to chromosome, telomeric region;regulation of double-strand break repair via homologous recombination;regulation of telomere maintenance;regulation of transcription, DNA-templated;telomere capping;telomere maintenance;telomere maintenance via telomerase;telomere maintenance via telomere lengthening;transcription, DNA-templated","G-rich strand telomeric DNA binding;phosphatase binding;telomeric DNA binding","chromosome, telomeric region;cytoplasm;cytosol;nuclear body;nuclear chromosome;nuclear chromosome, telomeric region;nuclear envelope;nuclear telomere cap complex;nucleoplasm;nucleus;shelterin complex",{"$nulls":3},2,2,2,"7.3","7.3","7.3","44.259",0,"4.5978",30479000,3,"0.217371","0.802317","-0.288207","-0.60584","sp|Q9NYB0|TE2IP_HUMAN","sp|Q9NYB0|TE2IP_HUMAN",2747,"Q9NYB0","TE2IP_HUMAN","Telomeric repeat-binding factor 2-interacting protein 1","ERF2-interacting telomeric protein 1;RF2-interacting telomeric protein 1","TERF2IP"]
["22.7266","22.721","23.4229","22.6013",{"$nulls":3},"activation of innate immune response;brain development;cell proliferation;cellular hyperosmotic salinity response;cellular response to fatty acid;cellular response to gamma radiation;cellular response to leukemia inhibitory factor;cellular response to X-ray;DNA recombination;double-strand break repair;double-strand break repair via nonhomologous end joining;establishment of integrated proviral latency;hematopoietic stem cell differentiation;innate immune response;negative regulation of t-circle formation;negative regulation of transcription, DNA-templated;neutrophil degranulation;positive regulation of catalytic activity;positive regulation of neurogenesis;positive regulation of protein kinase activity;positive regulation of telomerase activity;positive regulation of telomere maintenance via telomerase;positive regulation of type I interferon production;protein localization to chromosome, telomeric region;regulation of smooth muscle cell proliferation;regulation of telomere maintenance;response to drug;telomere maintenance;transcription, DNA-templated","ATP binding;ATP-dependent DNA helicase activity;damaged DNA binding;DNA binding;double-stranded DNA binding;enzyme activator activity;macromolecular complex binding;protein C-terminus binding;RNA binding;telomeric DNA binding;transcription regulatory region DNA binding;ubiquitin protein ligase binding","cytosol;extracellular region;intracellular ribonucleoprotein complex;Ku70:Ku80 complex;membrane;nonhomologous end joining complex;nuclear chromosome, telomeric region;nuclear telomere cap complex;nucleolus;nucleoplasm;nucleus;plasma membrane;protein complex;protein-DNA complex;secretory granule lumen","Non-homologous end-joining",null,null,17,17,17,"41.9","41.9","41.9","82.704",0,"323.31",2679300000,130,"0.255303","0.76846","-0.288285","-0.701722","sp|P13010|XRCC5_HUMAN;tr|C9JZ81|C9JZ81_HUMAN","sp|P13010|XRCC5_HUMAN",652,"P13010","XRCC5_HUMAN","X-ray repair cross-complementing protein 5",null,"XRCC5"]
["23.4815","22.815","23.405","23.4705",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleus;ribosome","Ribosome",null,null,4,4,4,36,36,36,"15.798",0,"6.7962",717300000,19,"0.320183","0.709279","-0.289484","-0.864517","sp|P61353|RL27_HUMAN;tr|K7ELC7|K7ELC7_HUMAN;tr|K7EQQ9|K7EQQ9_HUMAN;tr|K7ERY7|K7ERY7_HUMAN","sp|P61353|RL27_HUMAN;tr|K7ELC7|K7ELC7_HUMAN;tr|K7EQQ9|K7EQQ9_HUMAN",1271,"P61353","RL27_HUMAN","60S ribosomal protein L27",null,"RPL27"]
["19.0201","18.951","19.7798","18.7704",{"$nulls":3},"cell division;DNA repair;mitotic sister chromatid cohesion;negative regulation of DNA replication;sister chromatid cohesion",null,"chromatin;chromosome;chromosome, centromeric region;cytosol;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},11,11,11,"11.4","11.4","11.4","150.83",0,"126.79",421510000,54,"0.20426","0.817686","-0.289582","-0.572435","sp|Q29RF7|PDS5A_HUMAN;tr|H0Y9L6|H0Y9L6_HUMAN","sp|Q29RF7|PDS5A_HUMAN",1767,"Q29RF7","PDS5A_HUMAN","Sister chromatid cohesion protein PDS5 homolog A",null,"PDS5A"]
["17.678","17.5024","18.1581","17.6017",{"$nulls":3},"apoptotic process;autophagic cell death;autophagy;cellular response to amino acid starvation;cellular response to glucose starvation;membrane fission;positive regulation of autophagosome assembly;positive regulation of autophagy;positive regulation of membrane tubulation;positive regulation of protein oligomerization;positive regulation of protein targeting to mitochondrion;protein localization to vacuolar membrane;protein oligomerization;receptor catabolic process;regulation of cytokinesis;regulation of macroautophagy;regulation of protein stability","cadherin binding;identical protein binding;lipid binding;protein homodimerization activity","autophagosome membrane;cytoplasm;cytoplasmic vesicle;cytosol;extracellular exosome;Golgi membrane;midbody;mitochondrial outer membrane","Autophagy - animal;Endocytosis",null,null,1,1,1,"3.6","3.6","3.6","40.796",0,"8.2906",32183000,5,"0.371289","0.654412","-0.289707","-0.993098","sp|Q9Y371|SHLB1_HUMAN;tr|A0A087WW40|A0A087WW40_HUMAN","sp|Q9Y371|SHLB1_HUMAN;tr|A0A087WW40|A0A087WW40_HUMAN",2973,"Q9Y371","SHLB1_HUMAN","Endophilin-B1",null,"SH3GLB1"]
["20.9996","20.8175","21.3465","21.051",{"$nulls":3},"mitochondrial electron transport, ubiquinol to cytochrome c;response to antibiotic;response to drug;response to hormone","2 iron, 2 sulfur cluster binding;metal ion binding;protein complex binding;ubiquinol-cytochrome-c reductase activity","integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrial respiratory chain complex IV;mitochondrion","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,3,3,3,"13.9","13.9","13.9","29.668",0,"18.773",227120000,8,"0.626292","0.418108","-0.290211","-1.67229","sp|P47985|UCRI_HUMAN;sp|P0C7P4|UCRIL_HUMAN","sp|P47985|UCRI_HUMAN;sp|P0C7P4|UCRIL_HUMAN",600,"P47985","UCRI_HUMAN","Cytochrome b-c1 complex subunit Rieske, mitochondrial",null,"UQCRFS1"]
["19.7469","19.5184","20.4043","19.4415",{"$nulls":3},"apoptotic process;ceramide metabolic process;inactivation of MAPK activity;meiotic cell cycle;mesoderm development;mitotic nuclear envelope reassembly;negative regulation of cell growth;negative regulation of epithelial to mesenchymal transition;negative regulation of tyrosine phosphorylation of STAT protein;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of protein serine/threonine kinase activity;protein dephosphorylation;regulation of cell adhesion;regulation of cell differentiation;regulation of DNA replication;regulation of growth;regulation of transcription, DNA-templated;regulation of Wnt signaling pathway;response to organic substance;RNA splicing;second-messenger-mediated signaling","GABA receptor binding;metal ion binding;phosphoprotein phosphatase activity;protein C-terminus binding;protein heterodimerization activity","chromosome, centromeric region;cytosol;extracellular exosome;membrane;microtubule cytoskeleton;mitochondrion;nucleus;plasma membrane;protein phosphatase type 2A complex;spindle pole","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Autophagy - animal;Autophagy - other;Chagas disease (American trypanosomiasis);Dopaminergic synapse;Hepatitis C;Hippo signaling pathway;Human papillomavirus infection;Long-term depression;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway;TGF-beta signaling pathway;Tight junction",null,null,5,5,5,"28.5","28.5","28.5","35.594",0,"10.487",171140000,23,"0.209838","0.813869","-0.290244","-0.586667","sp|P67775|PP2AA_HUMAN;sp|P62714|PP2AB_HUMAN;tr|H0YC23|H0YC23_HUMAN;tr|E5RHC1|E5RHC1_HUMAN;tr|E5RI56|E5RI56_HUMAN;tr|E5RFI3|E5RFI3_HUMAN;tr|E5RHP4|E5RHP4_HUMAN;tr|E7ESG8|E7ESG8_HUMAN","sp|P67775|PP2AA_HUMAN;sp|P62714|PP2AB_HUMAN;tr|H0YC23|H0YC23_HUMAN",1351,"P67775","PP2AA_HUMAN","Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform","P2A-alpha","PPP2CA"]
["19.8159","19.6097","20.2982","19.7079",{"$nulls":3},"negative regulation of mitochondrial membrane potential;neutrophil degranulation;positive regulation of mitochondrial membrane permeability;positive regulation of necrotic cell death",null,"azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;mitochondrion",{"$nulls":3},2,2,2,"13.2","13.2","13.2","22.875",0,"3.7229",89741000,7,"0.345687","0.688383","-0.290274","-0.928567","sp|Q9Y5Z4|HEBP2_HUMAN;tr|Q5THN1|Q5THN1_HUMAN","sp|Q9Y5Z4|HEBP2_HUMAN;tr|Q5THN1|Q5THN1_HUMAN",3035,"Q9Y5Z4","HEBP2_HUMAN","Heme-binding protein 2",null,"HEBP2"]
["20.3305","20.0797","20.677","20.3162",{"$nulls":3},"intracellular protein transport;retrograde transport, endosome to Golgi","phosphatidylinositol binding","cytosol;retromer complex",{"$nulls":3},5,5,5,"21.1","21.1","21.1","35.592",0,"25.44",222420000,24,"0.500606","0.513315","-0.291535","-1.32682","tr|H0YK42|H0YK42_HUMAN;sp|Q13596|SNX1_HUMAN","tr|H0YK42|H0YK42_HUMAN;sp|Q13596|SNX1_HUMAN",1576,"H0YK42","H0YK42_HUMAN",null,null,"SNX1"]
["23.0684","22.8998","23.5299","23.0214",{"$nulls":3},"antigen processing and presentation;early endosome to Golgi transport;minus-end-directed organelle transport along microtubule;neutrophil degranulation;peptidyl-cysteine methylation;protein localization to Golgi apparatus;protein targeting to Golgi;retrograde vesicle-mediated transport, Golgi to ER;viral process","GTP binding;GTPase activity;myosin V binding;protein domain specific binding","cytoplasmic vesicle;cytosol;endoplasmic reticulum membrane;endosome to plasma membrane transport vesicle;extracellular exosome;Golgi apparatus;Golgi membrane;membrane;plasma membrane;secretory granule membrane;trans-Golgi network;trans-Golgi network membrane",{"$nulls":3},5,5,5,"23.6","23.6","23.6","23.593",0,"11.844",1236400000,32,"0.408864","0.609542","-0.291585","-1.0885","sp|P20340|RAB6A_HUMAN;tr|J3KR73|J3KR73_HUMAN;sp|Q9NRW1|RAB6B_HUMAN;tr|C9JB90|C9JB90_HUMAN;tr|C9JU14|C9JU14_HUMAN;tr|F5H3K7|F5H3K7_HUMAN;tr|F5GX61|F5GX61_HUMAN;sp|Q14964|RB39A_HUMAN","sp|P20340|RAB6A_HUMAN;tr|J3KR73|J3KR73_HUMAN;sp|Q9NRW1|RAB6B_HUMAN",742,"P20340","RAB6A_HUMAN","Ras-related protein Rab-6A","ab-6","RAB6A"]
["17.1902","16.6437","17.1035","17.3145",{"$nulls":3},"axon extension;behavioral response to cocaine;calcium ion import;cell cycle;cell division;cell proliferation;cell-matrix adhesion;cellular response to amyloid-beta;central nervous system neuron development;cerebellar cortex formation;chemical synaptic transmission;corpus callosum development;cortical actin cytoskeleton organization;dendrite morphogenesis;excitatory postsynaptic potential;hippocampus development;intracellular protein transport;layer formation in cerebral cortex;microtubule cytoskeleton organization;motor neuron axon guidance;negative regulation of axon extension;negative regulation of cell cycle;negative regulation of neuron death;negative regulation of protein export from nucleus;negative regulation of protein ubiquitination;negative regulation of proteolysis;negative regulation of synaptic plasticity;negative regulation of transcription, DNA-templated;neuron apoptotic process;neuron differentiation;neuron migration;neuron projection development;nucleocytoplasmic transport;oligodendrocyte differentiation;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;phosphorylation;positive regulation of actin cytoskeleton reorganization;positive regulation of calcium ion-dependent exocytosis;positive regulation of neuron apoptotic process;positive regulation of protein binding;positive regulation of protein kinase activity;positive regulation of protein targeting to membrane;protein autophosphorylation;protein localization to synapse;protein phosphorylation;receptor catabolic process;receptor clustering;regulation of apoptotic process;regulation of cell cycle arrest;regulation of cell migration;regulation of dendritic spine morphogenesis;regulation of macroautophagy;regulation of protein localization to plasma membrane;regulation of signal transduction by p53 class mediator;regulation of synaptic plasticity;regulation of synaptic transmission, glutamatergic;regulation of synaptic vesicle recycling;response to wounding;rhythmic process;Schwann cell development;sensory perception of pain;serine phosphorylation of STAT protein;skeletal muscle tissue development;synapse assembly;synaptic transmission, dopaminergic;synaptic transmission, glutamatergic;synaptic vesicle endocytosis;synaptic vesicle exocytosis;visual learning","acetylcholine receptor activator activity;ATP binding;cyclin-dependent protein serine/threonine kinase activity;cytoskeletal protein binding;ephrin receptor binding;ErbB-2 class receptor binding;ErbB-3 class receptor binding;kinase activity;p53 binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;tau-protein kinase activity","axon;cell junction;cyclin-dependent protein kinase 5 holoenzyme complex;cytoplasm;cytosol;dendrite;filopodium;growth cone;lamellipodium;membrane;microtubule;neuromuscular junction;neuronal cell body;nucleoplasm;nucleus;perikaryon;plasma membrane;postsynaptic density;postsynaptic membrane;presynapse","Alzheimer disease;Axon guidance;Cocaine addiction",null,null,1,1,1,"5.1","5.1","5.1","33.304","0.0010917","2.5439",25888000,4,"0.372893","0.651983","-0.292059","-0.997153","sp|Q00535|CDK5_HUMAN","sp|Q00535|CDK5_HUMAN",1404,"Q00535","CDK5_HUMAN","Cyclin-dependent-like kinase 5",null,"CDK5"]
["17.5112","17.282","18.1545","17.2237",{"$nulls":4},"kinetochore binding;microtubule plus-end binding","cytoplasmic microtubule;kinetochore microtubule",{"$nulls":3},5,5,5,6,6,6,"139.93",0,"27.85",145440000,17,"0.219119","0.802111","-0.292489","-0.610282","tr|H0Y5T1|H0Y5T1_HUMAN;tr|F8WA11|F8WA11_HUMAN;sp|Q7Z460|CLAP1_HUMAN;tr|C9JP76|C9JP76_HUMAN;tr|C9J151|C9J151_HUMAN","tr|H0Y5T1|H0Y5T1_HUMAN;tr|F8WA11|F8WA11_HUMAN;sp|Q7Z460|CLAP1_HUMAN",1954,"H0Y5T1","H0Y5T1_HUMAN",null,null,"CLASP1"]
["15.8188","15.7659","16.4331","15.7375",{"$nulls":3},"cilium assembly;in utero embryonic development;inositol phosphate metabolic process;lipid metabolic process;membrane organization;phosphatidylinositol biosynthetic process;phosphatidylinositol dephosphorylation;regulation of GTPase activity;regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity;inositol phosphate phosphatase activity;inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;inositol-1,4,5-trisphosphate 5-phosphatase activity;phosphatidylinositol phosphate 4-phosphatase activity;phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;Rac GTPase binding","clathrin-coated pit;clathrin-coated vesicle;cytoplasm;cytosol;early endosome;early endosome membrane;extracellular exosome;Golgi stack;Golgi-associated vesicle;nucleus;phagocytic vesicle membrane;photoreceptor outer segment;plasma membrane;trans-Golgi network","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,1,1,1,"1.2","1.2","1.2","104.2","0.0075633","1.7513",37089000,3,"0.310389","0.716096","-0.292988","-0.839959","sp|Q01968|OCRL_HUMAN","sp|Q01968|OCRL_HUMAN",1423,"Q01968","OCRL_HUMAN","Inositol polyphosphate 5-phosphatase OCRL-1",null,"OCRL"]
["18.7134","18.6351","19.4234","18.5129",{"$nulls":3},"protein dephosphorylation","protein serine/threonine phosphatase activity","nucleolus;nucleus",{"$nulls":3},1,1,1,"3.5","3.5","3.5","36.804",0,"5.6846",78173000,6,"0.232121","0.792493","-0.293893","-0.643242","sp|Q8WVY7|UBCP1_HUMAN","sp|Q8WVY7|UBCP1_HUMAN",2147,"Q8WVY7","UBCP1_HUMAN","Ubiquitin-like domain-containing CTD phosphatase 1",null,"UBLCP1"]
["23.8494","23.467","24.0522","23.8521",{"$nulls":3},"CTP biosynthetic process;GTP biosynthetic process;UTP biosynthetic process","ATP binding;nucleoside diphosphate kinase activity","cytosol",{"$nulls":3},10,10,5,"46.2","46.2","20.5","32.642",0,"48.744",3043900000,83,"0.513854","0.510673","-0.293921","-1.36206","tr|Q32Q12|Q32Q12_HUMAN;sp|P22392|NDKB_HUMAN;tr|J3KPD9|J3KPD9_HUMAN;sp|O60361|NDK8_HUMAN;tr|E7ERL0|E7ERL0_HUMAN;tr|F6XY72|F6XY72_HUMAN;tr|E5RHP0|E5RHP0_HUMAN;tr|C9K028|C9K028_HUMAN","tr|Q32Q12|Q32Q12_HUMAN;sp|P22392|NDKB_HUMAN;tr|J3KPD9|J3KPD9_HUMAN;sp|O60361|NDK8_HUMAN;tr|E7ERL0|E7ERL0_HUMAN",3115,"Q32Q12","Q32Q12_HUMAN","Nucleoside diphosphate kinase {ECO:0000256|RuleBase:RU004013}"]
["24.8725","24.6438","25.3662","24.7392",{"$nulls":3},"amyloid fibril formation;calcium ion transmembrane transport;chaperone-mediated protein folding;cytokine-mediated signaling pathway;'de novo' protein folding;heart morphogenesis;heart trabecula formation;muscle contraction;negative regulation of phosphoprotein phosphatase activity;negative regulation of protein phosphorylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of protein binding;positive regulation of protein ubiquitination;protein folding;protein maturation by protein folding;protein peptidyl-prolyl isomerization;protein refolding;regulation of activin receptor signaling pathway;regulation of amyloid precursor protein catabolic process;regulation of immune response;regulation of protein localization;regulation of ryanodine-sensitive calcium-release channel activity;release of sequestered calcium ion into cytosol;response to caffeine;response to iron ion;SMAD protein complex assembly;supramolecular fiber organization;T cell activation;T cell proliferation;transforming growth factor beta receptor signaling pathway;ventricular cardiac muscle tissue morphogenesis","activin binding;enzyme binding;FK506 binding;Hsp70 protein binding;ion channel binding;macrolide binding;peptidyl-prolyl cis-trans isomerase activity;protein homodimerization activity;signal transducer activity;SMAD binding;transforming growth factor beta receptor binding;type I transforming growth factor beta receptor binding","axon terminus;cytoplasm;cytoplasmic side of membrane;cytosol;extracellular exosome;extrinsic component of organelle membrane;membrane;ryanodine receptor complex;sarcoplasmic reticulum;terminal cisterna;Z disc",{"$nulls":3},2,2,2,25,25,25,"11.951",0,"17.782",876410000,17,"0.327359","0.705114","-0.294521","-0.882524","sp|P62942|FKB1A_HUMAN;tr|Q1JUQ3|Q1JUQ3_HUMAN;tr|Q1JUQ5|Q1JUQ5_HUMAN;tr|A0A087WTS4|A0A087WTS4_HUMAN;tr|Q5W0X3|Q5W0X3_HUMAN;tr|A0A087WV48|A0A087WV48_HUMAN;tr|A0A087WZM5|A0A087WZM5_HUMAN","sp|P62942|FKB1A_HUMAN;tr|Q1JUQ3|Q1JUQ3_HUMAN;tr|Q1JUQ5|Q1JUQ5_HUMAN;tr|A0A087WTS4|A0A087WTS4_HUMAN;tr|Q5W0X3|Q5W0X3_HUMAN;tr|A0A087WV48|A0A087WV48_HUMAN;tr|A0A087WZM5|A0A087WZM5_HUMAN",1335,"P62942","FKB1A_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP1A","PIase FKBP1A","FKBP1A"]
["19.2771","18.8941","19.8685","18.8925",{"$nulls":3},"acyl-CoA metabolic process","acetyl-CoA hydrolase activity;acyl-CoA hydrolase activity;carboxylic ester hydrolase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},6,6,6,"18.9","18.9","18.9","49.901",0,"89.019",192780000,36,"0.200393","0.82157","-0.294907","-0.56255","sp|Q9Y305|ACOT9_HUMAN;tr|H7C5Q2|H7C5Q2_HUMAN;tr|C9J7L8|C9J7L8_HUMAN","sp|Q9Y305|ACOT9_HUMAN;tr|H7C5Q2|H7C5Q2_HUMAN",2966,"Q9Y305","ACOT9_HUMAN","Acyl-coenzyme A thioesterase 9, mitochondrial","cyl-CoA thioesterase 9","ACOT9"]
["17.5631","17.2023","17.528","17.8279",{"$nulls":5},"cytoskeleton",{"$nulls":3},6,6,6,4,4,4,"204.49",0,"21.49",243120000,18,"0.474767","0.530098","-0.295261","-1.25874","tr|K7EKI8|K7EKI8_HUMAN;sp|O60437|PEPL_HUMAN;tr|K7EQ71|K7EQ71_HUMAN","tr|K7EKI8|K7EKI8_HUMAN;sp|O60437|PEPL_HUMAN;tr|K7EQ71|K7EQ71_HUMAN",287,"K7EKI8","K7EKI8_HUMAN",null,null,"PPL"]
["18.3575","19.2704","19.9292","18.2899",{"$nulls":4},"calcium ion binding",{"$nulls":4},4,4,4,"7.2","7.2","7.2","62.032",0,"36.491",168960000,12,"0.106476","0.912151","-0.29555","-0.315027","tr|E7EMB1|E7EMB1_HUMAN;sp|Q9UH65|SWP70_HUMAN;tr|E9PJM7|E9PJM7_HUMAN","tr|E7EMB1|E7EMB1_HUMAN;sp|Q9UH65|SWP70_HUMAN",2826,"E7EMB1","E7EMB1_HUMAN",null,null,"SWAP70"]
["14.6574","13.5656","14.4059","14.4083",{"$nulls":3},"ERBB signaling pathway;mRNA transport;negative regulation of protein autophosphorylation;negative regulation of protein tyrosine kinase activity;negative regulation of signaling;neutrophil degranulation;protein transport","identical protein binding;protein kinase binding;protein phosphatase binding","cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular ribonucleoprotein complex;membrane;nuclear pore;nucleus;perinuclear region of cytoplasm;secretory granule lumen",{"$nulls":3},2,2,2,"5.5","5.5","5.5","99.326",0,"3.9195",11695000,3,"0.19219","0.830811","-0.29563","-0.54152","sp|Q14764|MVP_HUMAN","sp|Q14764|MVP_HUMAN",1644,"Q14764","MVP_HUMAN","Major vault protein","VP","MVP"]
["20.3144","20.1121","20.6785","20.3393",{"$nulls":3},"axonogenesis;cristae formation;mitochondrial calcium ion homeostasis;mitochondrial calcium ion transmembrane transport;mitochondrial calcium uptake;mitochondrial fusion;mitochondrial protein processing;muscle fiber development;myelination;nerve development;neuromuscular junction development;protein autoprocessing;protein processing;proteolysis;regulation of multicellular organism growth;righting reflex","ATP binding;metalloendopeptidase activity;metallopeptidase activity;unfolded protein binding;zinc ion binding","m-AAA complex;mitochondrial inner membrane;mitochondrion",{"$nulls":3},6,6,6,"10.9","10.9","10.9","88.583",0,"63.098",432560000,21,"0.563779","0.470821","-0.295643","-1.49719","sp|Q9Y4W6|AFG32_HUMAN;tr|K7EP56|K7EP56_HUMAN","sp|Q9Y4W6|AFG32_HUMAN",3007,"Q9Y4W6","AFG32_HUMAN","AFG3-like protein 2",null,"AFG3L2"]
["26.5708","26.512","27.1679","26.5073",{"$nulls":3},"canonical glycolysis;gluconeogenesis;negative regulation of cell growth;negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of ATP biosynthetic process;positive regulation of muscle contraction;positive regulation of plasminogen activation;response to virus;transcription, DNA-templated","cadherin binding;GTPase binding;magnesium ion binding;phosphopyruvate hydratase activity;protein homodimerization activity;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cell cortex region;cell surface;cytoplasm;cytosol;extracellular exosome;extracellular space;M band;membrane;nucleus;phosphopyruvate hydratase complex;plasma membrane","Biosynthesis of amino acids;Carbon metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;RNA degradation",null,null,19,19,18,"59.2","59.2","59.2","47.168",0,"323.31",23063000000,327,"0.331625","0.70242","-0.296171","-0.893232","sp|P06733|ENOA_HUMAN;tr|K7EM90|K7EM90_HUMAN;tr|E5RI09|E5RI09_HUMAN;tr|E5RG95|E5RG95_HUMAN;tr|K7EPM1|K7EPM1_HUMAN;tr|K7EKN2|K7EKN2_HUMAN;tr|E5RGZ4|E5RGZ4_HUMAN;sp|P13929|ENOB_HUMAN","sp|P06733|ENOA_HUMAN",532,"P06733","ENOA_HUMAN","Alpha-enolase",null,"ENO1"]
["20.4338","20.1858","21.1557","20.0566",{"$nulls":3},"cellular chloride ion homeostasis;cerebellum development;creatine metabolic process;substantia nigra development","ATP binding;creatine kinase activity;ubiquitin protein ligase binding","cytosol;dendrite;extracellular exosome;extracellular space;mitochondrion;myelin sheath;neuronal cell body;nucleus","Arginine and proline metabolism;Metabolic pathways",null,null,6,6,6,"23.9","23.9","23.9","42.644",0,"33.993",280400000,28,"0.186144","0.834592","-0.296315","-0.525968","sp|P12277|KCRB_HUMAN;tr|G3V4N7|G3V4N7_HUMAN;tr|G3V461|G3V461_HUMAN;tr|H0YJG0|H0YJG0_HUMAN","sp|P12277|KCRB_HUMAN;tr|G3V4N7|G3V4N7_HUMAN",645,"P12277","KCRB_HUMAN","Creatine kinase B-type {ECO:0000305}",null,"CKB"]
["22.1117","21.9932","22.9111","21.787",{"$nulls":4},"GTP binding",{"$nulls":4},8,8,5,"22.4","22.4","15.8","49.005",0,"124.45",1158300000,48,"0.185678","0.834458","-0.296571","-0.524768","tr|D6RGI3|D6RGI3_HUMAN;sp|Q9NVA2|SEP11_HUMAN;tr|D6RER5|D6RER5_HUMAN;tr|H0Y961|H0Y961_HUMAN;tr|D6RDU5|D6RDU5_HUMAN;tr|H0Y9G8|H0Y9G8_HUMAN;tr|D6RDP1|D6RDP1_HUMAN;tr|D6R9Y6|D6R9Y6_HUMAN","tr|D6RGI3|D6RGI3_HUMAN;sp|Q9NVA2|SEP11_HUMAN;tr|D6RER5|D6RER5_HUMAN;tr|H0Y961|H0Y961_HUMAN;tr|D6RDU5|D6RDU5_HUMAN",2718,"D6RGI3","D6RGI3_HUMAN"]
["15.2971","16.5513","15.0672","17.3747",{"$nulls":3},"ceramide translocation;G2/M transition of mitotic cell cycle;phospholipid translocation;positive regulation of anion channel activity;regulation of chloride transport;regulation of response to osmotic stress;response to drug;stem cell proliferation;transmembrane transport;transport","ATP binding;ATPase activity, coupled to transmembrane movement of substances;ceramide-translocating ATPase activity;phosphatidylcholine-translocating ATPase activity;phosphatidylethanolamine-translocating ATPase activity;transporter activity;xenobiotic transmembrane transporting ATPase activity","apical plasma membrane;cell surface;extracellular exosome;integral component of membrane;membrane;plasma membrane","ABC transporters;Bile secretion;Gastric cancer;MicroRNAs in cancer",null,null,3,3,3,"3.7","3.7","3.7","141.48",0,"7.1794",24282000,4,"0.0745784","0.931229","-0.296735","-0.225976","sp|P08183|MDR1_HUMAN","sp|P08183|MDR1_HUMAN",556,"P08183","MDR1_HUMAN","Multidrug resistance protein 1",null,"ABCB1"]
["21.2801","21.2512","22.0429","21.0834",{"$nulls":3},"regulation of transcription, DNA-templated","cadherin binding;DNA binding;lamin binding","chromatin;nuclear envelope;nucleus",{"$nulls":3},12,12,7,"33.4","33.4","19.9","75.491",0,"191.21",982250000,56,"0.222893","0.800325","-0.297517","-0.619863","sp|P42166|LAP2A_HUMAN","sp|P42166|LAP2A_HUMAN",990,"P42166","LAP2A_HUMAN","Lamina-associated polypeptide 2, isoform alpha",null,"TMPO"]
["20.9754","21.0687","21.8323","20.807",{"$nulls":3},"cellular iron ion homeostasis;cellular response to drug;cellular response to leukemia inhibitory factor;iron ion import;membrane organization;osteoclast differentiation;positive regulation of B cell proliferation;positive regulation of bone resorption;positive regulation of isotype switching;positive regulation of T cell proliferation;receptor internalization;transferrin transport","double-stranded RNA binding;identical protein binding;protein homodimerization activity;RNA binding;transferrin receptor activity;transferrin transmembrane transporter activity;virus receptor activity","basolateral plasma membrane;blood microparticle;cell surface;clathrin-coated pit;clathrin-coated vesicle membrane;cytoplasmic vesicle;early endosome;endosome;endosome membrane;external side of plasma membrane;extracellular exosome;extracellular region;extracellular space;extracellular vesicle;HFE-transferrin receptor complex;integral component of plasma membrane;melanosome;membrane;perinuclear region of cytoplasm;plasma membrane;recycling endosome","Endocytosis;Ferroptosis;Hematopoietic cell lineage;HIF-1 signaling pathway;Phagosome",null,null,9,9,9,"15.5","15.5","15.5","84.87",0,"85.769",832250000,40,"0.206447","0.816395","-0.297568","-0.57802","sp|P02786|TFR1_HUMAN;tr|G3V0E5|G3V0E5_HUMAN;tr|H7C3V5|H7C3V5_HUMAN;tr|F8WBE5|F8WBE5_HUMAN","sp|P02786|TFR1_HUMAN;tr|G3V0E5|G3V0E5_HUMAN",483,"P02786","TFR1_HUMAN","Transferrin receptor protein 1","fR;fR1;R;rfr","TFRC"]
["24.0002","24.0176","24.4444","24.1691",{"$nulls":3},"intracellular cholesterol transport",null,"intracellular",{"$nulls":3},7,7,7,"56.1","56.1","56.1","16.23",0,"27.692",1809900000,45,"0.786632","0.333569","-0.29784","-2.15936","tr|J3KMY5|J3KMY5_HUMAN;sp|P61916|NPC2_HUMAN;tr|G3V3E8|G3V3E8_HUMAN;tr|E7EMS2|E7EMS2_HUMAN;tr|G3V3D1|G3V3D1_HUMAN;tr|H0YIZ1|H0YIZ1_HUMAN;tr|G3V2V8|G3V2V8_HUMAN","tr|J3KMY5|J3KMY5_HUMAN;sp|P61916|NPC2_HUMAN;tr|G3V3E8|G3V3E8_HUMAN;tr|E7EMS2|E7EMS2_HUMAN;tr|G3V3D1|G3V3D1_HUMAN;tr|H0YIZ1|H0YIZ1_HUMAN;tr|G3V2V8|G3V2V8_HUMAN",1282,"J3KMY5","J3KMY5_HUMAN",null,null,"NPC2"]
["25.2116","25.0374","25.7021","25.1429",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosome biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;rRNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleoplasm;nucleus;ribosome;small ribosomal subunit","Ribosome",null,null,9,9,9,"43.4","43.4","43.4","17.718",0,"141.91",3662600000,55,"0.380931","0.640866","-0.297967","-1.01749","sp|P62269|RS18_HUMAN;tr|A0A0G2JQH2|A0A0G2JQH2_HUMAN;tr|Q5GGW2|Q5GGW2_HUMAN;tr|J3JS69|J3JS69_HUMAN","sp|P62269|RS18_HUMAN",1299,"P62269","RS18_HUMAN","40S ribosomal protein S18",null,"RPS18"]
["23.1442","23.2839","23.8162","23.2101",{"$nulls":3},"animal organ regeneration;defense response to bacterium;hippocampus development;neutrophil degranulation;phagocytosis;positive regulation of angiogenesis;positive regulation of DNA binding transcription factor activity;positive regulation of DNA metabolic process;positive regulation of endothelial cell migration;response to glucocorticoid;response to growth factor","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;phospholipase A2 inhibitor activity","axon;cytoplasm;cytosol;dendrite;extracellular exosome;membrane;neuronal cell body;phagocytic vesicle membrane;plasma membrane;specific granule",{"$nulls":3},11,11,11,"35.3","35.3","35.3","36.375",0,"40.084",2296000000,49,"0.358812","0.67109","-0.299061","-0.961611","sp|P12429|ANXA3_HUMAN;tr|D6RA82|D6RA82_HUMAN;tr|D6RFG5|D6RFG5_HUMAN;tr|D6RCA8|D6RCA8_HUMAN;tr|D6RAZ8|D6RAZ8_HUMAN;tr|D6RFJ9|D6RFJ9_HUMAN","sp|P12429|ANXA3_HUMAN;tr|D6RA82|D6RA82_HUMAN",646,"P12429","ANXA3_HUMAN","Annexin A3",null,"ANXA3"]
["19.4112","19.3699","19.6608","19.7194",{"$nulls":3},"activation of innate immune response;centriole assembly;DNA recombination;DNA repair;DNA replication;glucocorticoid receptor signaling pathway;histone deacetylation;innate immune response;intracellular estrogen receptor signaling pathway;negative regulation of centriole replication;positive regulation of transcription from RNA polymerase II promoter;response to hormone;SMAD protein signal transduction;transcription, DNA-templated","ligand-dependent nuclear receptor transcription coactivator activity;protein binding, bridging;RNA binding;RNA polymerase II transcription cofactor activity","cytoplasm;intracellular ribonucleoprotein complex;mediator complex;nuclear speck;nucleolus;nucleoplasm;nucleus;transcription factor complex",{"$nulls":3},4,4,4,"9.3","9.3","9.3","69.491",0,"10.954",129590000,12,"1.85343","0.389552","-0.299579","-8.35816","sp|Q96PK6|RBM14_HUMAN","sp|Q96PK6|RBM14_HUMAN",2334,"Q96PK6","RBM14_HUMAN","RNA-binding protein 14",null,"RBM14"]
["19.4292","19.3077","20.3285","19.0082",{"$nulls":3},"aromatic amino acid family metabolic process","catalytic activity","cytoplasm",{"$nulls":3},2,2,2,18,18,18,"21.074",0,"4.9775",64732000,3,"0.157794","0.867809","-0.299872","-0.452335","tr|G3V267|G3V267_HUMAN;tr|G3V5T0|G3V5T0_HUMAN;tr|A0A0C4DFM0|A0A0C4DFM0_HUMAN;sp|O43708|MAAI_HUMAN;tr|G3V4T6|G3V4T6_HUMAN;tr|H0YJN8|H0YJN8_HUMAN;tr|G3V3B9|G3V3B9_HUMAN;tr|A0A0A0MR33|A0A0A0MR33_HUMAN","tr|G3V267|G3V267_HUMAN;tr|G3V5T0|G3V5T0_HUMAN;tr|A0A0C4DFM0|A0A0C4DFM0_HUMAN;sp|O43708|MAAI_HUMAN;tr|G3V4T6|G3V4T6_HUMAN;tr|H0YJN8|H0YJN8_HUMAN;tr|G3V3B9|G3V3B9_HUMAN;tr|A0A0A0MR33|A0A0A0MR33_HUMAN",260,"G3V267","G3V267_HUMAN",null,null,"GSTZ1"]
["19.0591","18.4082","18.7059","19.3618",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"6.3","6.3","6.3","66.175",0,"95.466",139880000,22,"0.234666","0.789782","-0.300159","-0.649678","tr|S4R3V8|S4R3V8_HUMAN;sp|Q86X29|LSR_HUMAN","tr|S4R3V8|S4R3V8_HUMAN;sp|Q86X29|LSR_HUMAN",1994,"S4R3V8","S4R3V8_HUMAN",null,null,"LSR"]
["21.2568","21.0407","21.9054","20.9927",{"$nulls":3},"aging;cellular protein modification process;protein N-linked glycosylation;protein N-linked glycosylation via asparagine;response to drug","ribosome binding","autophagosome membrane;endoplasmic reticulum membrane;integral component of membrane;membrane;oligosaccharyltransferase complex;rough endoplasmic reticulum","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,13,13,13,"35.2","35.2","35.2","69.283",0,"69.309",608700000,75,"0.230936","0.792526","-0.300253","-0.640243","sp|P04844|RPN2_HUMAN;tr|Q5JYR7|Q5JYR7_HUMAN;tr|Q5JYR4|Q5JYR4_HUMAN;tr|Q5JYR3|Q5JYR3_HUMAN;tr|F2Z3K5|F2Z3K5_HUMAN;tr|H0Y5M1|H0Y5M1_HUMAN","sp|P04844|RPN2_HUMAN",504,"P04844","RPN2_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2",null,"RPN2"]
["20.643","20.4978","21.2157","20.5269",{"$nulls":3},"IRES-dependent viral translational initiation;regulation of translational initiation;translational initiation;viral translational termination-reinitiation","protein complex scaffold activity;RNA binding;translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;extracellular exosome","RNA transport",null,null,15,15,15,"27.6","27.6","27.6","92.48",0,"63.803",726790000,57,"0.316373","0.714089","-0.300941","-0.854964","sp|P55884|EIF3B_HUMAN;tr|C9JZG1|C9JZG1_HUMAN;tr|C9JQN7|C9JQN7_HUMAN","sp|P55884|EIF3B_HUMAN",1216,"P55884","EIF3B_HUMAN","Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001}","IF3b {ECO:0000255|HAMAP-Rule:MF_03001}","EIF3B"]
["21.9263","21.9511","22.1906","22.2897",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;activation of signaling protein activity involved in unfolded protein response;apoptotic mitochondrial changes;apoptotic process;apoptotic process involved in blood vessel morphogenesis;apoptotic process involved in embryonic digit morphogenesis;apoptotic signaling pathway;B cell apoptotic process;B cell homeostasis;B cell homeostatic proliferation;B cell negative selection;B cell receptor apoptotic signaling pathway;blood vessel remodeling;cellular response to UV;cerebral cortex development;development of secondary sexual characteristics;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;ectopic germ cell programmed cell death;endoplasmic reticulum calcium ion homeostasis;establishment or maintenance of transmembrane electrochemical gradient;extrinsic apoptotic signaling pathway;extrinsic apoptotic signaling pathway in absence of ligand;extrinsic apoptotic signaling pathway via death domain receptors;fertilization;germ cell development;glycosphingolipid metabolic process;homeostasis of number of cells within a tissue;hypothalamus development;intrinsic apoptotic signaling pathway;intrinsic apoptotic signaling pathway by p53 class mediator;intrinsic apoptotic signaling pathway in response to DNA damage;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;kidney development;mitochondrial fragmentation involved in apoptotic process;mitochondrial fusion;mitochondrion morphogenesis;myeloid cell homeostasis;negative regulation of apoptotic signaling pathway;negative regulation of endoplasmic reticulum calcium ion concentration;negative regulation of fibroblast proliferation;negative regulation of neuron apoptotic process;negative regulation of peptidyl-serine phosphorylation;negative regulation of protein binding;neuron apoptotic process;neuron migration;odontogenesis of dentin-containing tooth;ovarian follicle development;positive regulation of apoptotic DNA fragmentation;positive regulation of apoptotic process;positive regulation of apoptotic process involved in mammary gland involution;positive regulation of B cell apoptotic process;positive regulation of developmental pigmentation;positive regulation of endoplasmic reticulum unfolded protein response;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of IRE1-mediated unfolded protein response;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of neuron apoptotic process;positive regulation of protein oligomerization;positive regulation of release of cytochrome c from mitochondria;positive regulation of release of sequestered calcium ion into cytosol;post-embryonic camera-type eye morphogenesis;protein homooligomerization;protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein oligomerization;regulation of apoptotic process;regulation of mammary gland epithelial cell proliferation;regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;regulation of mitochondrial membrane potential;regulation of nitrogen utilization;regulation of protein heterodimerization activity;regulation of protein homodimerization activity;release of cytochrome c from mitochondria;release of matrix enzymes from mitochondria;response to axon injury;response to gamma radiation;response to salt stress;response to toxic substance;retina development in camera-type eye;retinal cell programmed cell death;Sertoli cell proliferation;spermatid differentiation;T cell homeostatic proliferation;thymocyte apoptotic process;transcription initiation from RNA polymerase II promoter;vagina development;viral process","BH3 domain binding;channel activity;chaperone binding;Hsp70 protein binding;identical protein binding;lipid binding;protein heterodimerization activity;protein homodimerization activity","BAX complex;Bcl-2 family protein complex;cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;membrane;mitochondrial outer membrane;mitochondrial permeability transition pore complex;mitochondrion;nuclear envelope;nucleus;pore complex","AGE-RAGE signaling pathway in diabetic complications;Amyotrophic lateral sclerosis (ALS);Apoptosis;Apoptosis - multiple species;Basal cell carcinoma;Breast cancer;Chronic myeloid leukemia;Colorectal cancer;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;Epstein-Barr virus infection;Gastric cancer;Glioma;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Longevity regulating pathway;Measles;Melanoma;Necroptosis;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Non-small cell lung cancer;p53 signaling pathway;Pancreatic cancer;Pathways in cancer;Platinum drug resistance;Prion diseases;Protein processing in endoplasmic reticulum;Small cell lung cancer;Sphingolipid signaling pathway;Thyroid cancer;Transcriptional misregulation in cancer;Tuberculosis;Viral carcinogenesis",null,null,5,5,5,"35.9","35.9","35.9","21.184",0,"20.61",338790000,35,"1.56011","0.3328","-0.301475","-5.9012","sp|Q07812|BAX_HUMAN;tr|K4JQN1|K4JQN1_HUMAN;tr|I6LPK7|I6LPK7_HUMAN","sp|Q07812|BAX_HUMAN",1467,"Q07812","BAX_HUMAN","Apoptosis regulator BAX",null,"BAX"]
["19.9572","19.7898","20.6791","19.6722",{"$nulls":3},"cap-dependent translational initiation;formation of cytoplasmic translation initiation complex;IRES-dependent viral translational initiation;positive regulation of mRNA binding;positive regulation of translation;translational initiation;viral translational termination-reinitiation","mRNA cap binding;RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;membrane","RNA transport",null,null,8,8,8,"16.1","16.1","16.1","63.972",0,"16.777",271120000,27,"0.211978","0.812063","-0.302187","-0.592119","sp|O15371|EIF3D_HUMAN;tr|B0QYA4|B0QYA4_HUMAN;tr|B0QYA8|B0QYA8_HUMAN;tr|B0QYA6|B0QYA6_HUMAN;tr|B0QYA5|B0QYA5_HUMAN","sp|O15371|EIF3D_HUMAN",217,"O15371","EIF3D_HUMAN","Eukaryotic translation initiation factor 3 subunit D {ECO:0000255|HAMAP-Rule:MF_03003}","IF3d {ECO:0000255|HAMAP-Rule:MF_03003}","EIF3D"]
["21.8067","21.393","22.2494","21.5598",{"$nulls":3},"formaldehyde catabolic process","carboxylic ester hydrolase activity;S-formylglutathione hydrolase activity","cytoplasm",{"$nulls":3},4,4,4,"31.3","31.3","31.3","25.368",0,"51.446",340210000,19,"0.277714","0.753079","-0.30479","-0.758031","tr|H7BZT7|H7BZT7_HUMAN;tr|X6RA14|X6RA14_HUMAN;sp|P10768|ESTD_HUMAN;tr|U3KQT1|U3KQT1_HUMAN","tr|H7BZT7|H7BZT7_HUMAN;tr|X6RA14|X6RA14_HUMAN;sp|P10768|ESTD_HUMAN;tr|U3KQT1|U3KQT1_HUMAN",612,"H7BZT7","H7BZT7_HUMAN","S-formylglutathione hydrolase {ECO:0000256|RuleBase:RU363068}",null,"ESD"]
["19.2763","18.3972","19.162","19.1211",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;ER to Golgi vesicle-mediated transport;nuclear migration","protein N-terminus binding","centrosome;cytoplasm;cytoplasmic dynein complex;cytosol;dynactin complex;focal adhesion;kinetochore;nucleus;spindle pole;stress fiber","Huntington disease;Vasopressin-regulated water reabsorption",null,null,5,5,5,"22.4","22.4","22.4","52.337",0,"20.384",144030000,17,"0.251761","0.772119","-0.304826","-0.692807","sp|Q9UJW0|DCTN4_HUMAN;tr|E5RGG1|E5RGG1_HUMAN;tr|H9KVE0|H9KVE0_HUMAN","sp|Q9UJW0|DCTN4_HUMAN",2860,"Q9UJW0","DCTN4_HUMAN","Dynactin subunit 4","yn4","DCTN4"]
["22.1004","22.0593","22.5188","22.252",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;movement of cell or subcellular component;response to estradiol;response to estrogen","actin binding;protein complex binding;structural constituent of cytoskeleton","actin cytoskeleton;Arp2/3 protein complex;cytosol;extracellular exosome;focal adhesion;tubulobulbar complex","Bacterial invasion of epithelial cells;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,3,3,3,"12.9","12.9","12.9","40.949",0,"13.321",981750000,24,"0.818511","0.321639","-0.305529","-2.26394","sp|O15143|ARC1B_HUMAN;tr|C9JTT6|C9JTT6_HUMAN;tr|C9JBJ7|C9JBJ7_HUMAN;tr|C9K057|C9K057_HUMAN;tr|C9J4Z7|C9J4Z7_HUMAN;tr|F8VXW2|F8VXW2_HUMAN;tr|C9JEY1|C9JEY1_HUMAN;tr|C9JQM8|C9JQM8_HUMAN;tr|C9JFG9|C9JFG9_HUMAN;tr|C9J6C8|C9J6C8_HUMAN","sp|O15143|ARC1B_HUMAN",200,"O15143","ARC1B_HUMAN","Actin-related protein 2/3 complex subunit 1B",null,"ARPC1B"]
["20.8068","20.8496","21.5746","20.6929",{"$nulls":3},"intracellular transport of virus;mRNA transport;negative regulation of transcription from RNA polymerase II promoter;nucleocytoplasmic transport;protein export from nucleus;protein localization to nucleus;regulation of centrosome duplication;regulation of mRNA stability;regulation of protein catabolic process;regulation of protein export from nucleus;response to drug;ribosomal large subunit export from nucleus;ribosomal small subunit export from nucleus;ribosomal subunit export from nucleus;ribosome biogenesis;sister chromatid cohesion;viral process","nuclear export signal receptor activity;nucleocytoplasmic transporter activity;protein domain specific binding;Ran GTPase binding;RNA binding;transporter activity","annulate lamellae;Cajal body;cytoplasm;cytosol;host cell;intracellular membrane-bounded organelle;intracellular ribonucleoprotein complex;kinetochore;membrane;nuclear envelope;nuclear membrane;nucleolus;nucleoplasm;nucleus;protein complex","Human T-cell leukemia virus 1 infection;Influenza A;Ribosome biogenesis in eukaryotes;RNA transport",null,null,19,19,19,"25.7","25.7","25.7","123.38",0,"162.72",1095500000,102,"0.251535","0.771897","-0.305561","-0.692236","sp|O14980|XPO1_HUMAN;tr|C9JKM9|C9JKM9_HUMAN;tr|H7BZC5|H7BZC5_HUMAN;tr|C9IZS4|C9IZS4_HUMAN;tr|C9JQ02|C9JQ02_HUMAN;tr|C9JV99|C9JV99_HUMAN;tr|C9J673|C9J673_HUMAN;tr|F8WF71|F8WF71_HUMAN","sp|O14980|XPO1_HUMAN",188,"O14980","XPO1_HUMAN","Exportin-1","xp1","XPO1"]
["17.6655","17.9662","18.6426","17.6007",{"$nulls":4},"metal ion binding",{"$nulls":4},3,3,3,"5.5","5.5","5.5","77.667",0,"37.793",75546000,14,"0.200961","0.822069","-0.305825","-0.564003","sp|Q8ND24|RN214_HUMAN;tr|E9PRE9|E9PRE9_HUMAN;tr|E9PN76|E9PN76_HUMAN","sp|Q8ND24|RN214_HUMAN",2086,"Q8ND24","RN214_HUMAN","RING finger protein 214",null,"RNF214"]
["23.7948","23.64","24.3803","23.6662",{"$nulls":3},"glyceraldehyde-3-phosphate biosynthetic process;pentose-phosphate shunt;pentose-phosphate shunt, non-oxidative branch;regulation of growth;xylulose biosynthetic process","cofactor binding;metal ion binding;protein homodimerization activity;transketolase activity","cytosol;extracellular exosome;myelin sheath;nuclear body;nuclear speck;nucleoplasm;peroxisome;vesicle","Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,16,16,16,"37.7","37.7","37.7","67.877",0,"133.89",3607200000,131,"0.309295","0.716121","-0.305853","-0.837215","sp|P29401|TKT_HUMAN;tr|A0A0B4J1R6|A0A0B4J1R6_HUMAN;tr|E9PFF2|E9PFF2_HUMAN;tr|F8W888|F8W888_HUMAN;tr|F8WAX4|F8WAX4_HUMAN","sp|P29401|TKT_HUMAN;tr|A0A0B4J1R6|A0A0B4J1R6_HUMAN",849,"P29401","TKT_HUMAN","Transketolase","K","TKT"]
["19.7924","19.8855","20.5014","19.7883",{"$nulls":3},"cell cycle;cell division","protein phosphatase inhibitor activity","cytoplasm",{"$nulls":3},2,1,1,"28.2","12.7","12.7","7.6866","0.0047297","1.9463",52885000,9,"0.314708","0.714617","-0.305953","-0.850788","tr|H3BQ52|H3BQ52_HUMAN;tr|H3BTD3|H3BTD3_HUMAN;sp|P56211|ARP19_HUMAN;tr|H3BMD8|H3BMD8_HUMAN","tr|H3BQ52|H3BQ52_HUMAN;tr|H3BTD3|H3BTD3_HUMAN;sp|P56211|ARP19_HUMAN;tr|H3BMD8|H3BMD8_HUMAN",1222,"H3BQ52","H3BQ52_HUMAN",null,null,"ARPP19"]
["19.7905","19.4295","20.3824","19.4499",{"$nulls":3},"acrosome assembly;intermediate filament organization;membrane organization;mRNA export from nucleus;multicellular organism development;spermatid nucleus differentiation","DNA binding;GTPase activator activity;metal ion binding;RNA binding","cell projection;cytoplasmic vesicle;cytosol;intracellular membrane-bounded organelle;neuronal cell body;nuclear pore",{"$nulls":3},4,4,4,"14.4","14.4","14.4","58.259",0,"32.519",164120000,27,"0.219953","0.801928","-0.306171","-0.612402","sp|P52594|AGFG1_HUMAN;tr|C9J2I0|C9J2I0_HUMAN;tr|B8ZZY2|B8ZZY2_HUMAN","sp|P52594|AGFG1_HUMAN;tr|C9J2I0|C9J2I0_HUMAN;tr|B8ZZY2|B8ZZY2_HUMAN",1159,"P52594","AGFG1_HUMAN","Arf-GAP domain and FG repeat-containing protein 1",null,"AGFG1"]
["23.0912","22.9431","23.6006","23.0489",{"$nulls":3},"actin cytoskeleton organization;regulation of actin filament polymerization","actin binding",{"$nulls":4},1,1,1,"15.4","15.4","15.4","9.7982",0,"8.8243",530350000,9,"0.40434","0.616267","-0.307582","-1.07696","tr|C9J712|C9J712_HUMAN;tr|C9J0J7|C9J0J7_HUMAN;tr|C9JQ45|C9JQ45_HUMAN;sp|P35080|PROF2_HUMAN;tr|G5E9Q6|G5E9Q6_HUMAN","tr|C9J712|C9J712_HUMAN;tr|C9J0J7|C9J0J7_HUMAN;tr|C9JQ45|C9JQ45_HUMAN;sp|P35080|PROF2_HUMAN;tr|G5E9Q6|G5E9Q6_HUMAN",919,"C9J712","C9J712_HUMAN","Profilin {ECO:0000256|RuleBase:RU003909}",null,"PFN2"]
["19.4956","18.8868","19.7592","19.2388",{"$nulls":3},"cellular glucuronidation;glucuronoside catabolic process","hydrolase activity, hydrolyzing O-glycosyl compounds;mycophenolic acid acyl-glucuronide esterase activity","cytosol;mitochondrial matrix;mitochondrion",{"$nulls":3},2,2,2,"11.4","11.4","11.4","33.932",0,"33.609",95877000,12,"0.281866","0.748147","-0.307737","-0.768447","sp|Q9NUJ1|ABHDA_HUMAN","sp|Q9NUJ1|ABHDA_HUMAN",2704,"Q9NUJ1","ABHDA_HUMAN","Mycophenolic acid acyl-glucuronide esterase, mitochondrial",null,"ABHD10"]
["14.4493","15.5422","14.8239","15.7834",{"$nulls":3},"regulation of small GTPase mediated signal transduction","GTPase activator activity","cytosol;nucleus;plasma membrane",{"$nulls":3},2,2,2,"1.6","1.6","1.6","194.93","0.0027701","2.1723",19675000,3,"0.146783","0.87704","-0.307874","-0.423367","tr|H7C1F9|H7C1F9_HUMAN;sp|Q2PPJ7|RGPA2_HUMAN","tr|H7C1F9|H7C1F9_HUMAN;sp|Q2PPJ7|RGPA2_HUMAN",1773,"H7C1F9","H7C1F9_HUMAN",null,null,"RALGAPA2"]
["21.2682","21.1343","21.7473","21.2713",{"$nulls":3},"cellular nitrogen compound metabolic process;dicarboxylic acid metabolic process;excretion;metabolic process;oxidation-reduction process;protein oligomerization","carboxylic acid binding;glycerate dehydrogenase activity;glyoxylate reductase (NADP) activity;hydroxypyruvate reductase activity;NAD binding;NADPH binding;protein homodimerization activity","cytoplasm;cytosol;extracellular exosome;peroxisomal matrix","Glycine, serine and threonine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Pyruvate metabolism",null,null,5,5,5,"25.9","25.9","25.9","35.668",0,"35.079",392270000,25,"0.469968","0.5338","-0.308069","-1.24619","sp|Q9UBQ7|GRHPR_HUMAN;tr|U3KQ56|U3KQ56_HUMAN","sp|Q9UBQ7|GRHPR_HUMAN;tr|U3KQ56|U3KQ56_HUMAN",2808,"Q9UBQ7","GRHPR_HUMAN","Glyoxylate reductase/hydroxypyruvate reductase",null,"GRHPR"]
["21.1726","21.1428","22.1093","20.823",{"$nulls":3},"AMP metabolic process;blood coagulation;GTP metabolic process;ITP metabolic process;UTP metabolic process","ATP binding;GTP binding;nucleoside triphosphate adenylate kinase activity","mitochondrial matrix;mitochondrion","Purine metabolism",null,null,8,8,8,"44.1","44.1","44.1","25.565",0,"45.922",449700000,29,"0.168181","0.853928","-0.30845","-0.479462","sp|Q9UIJ7|KAD3_HUMAN","sp|Q9UIJ7|KAD3_HUMAN",2850,"Q9UIJ7","KAD3_HUMAN","GTP:AMP phosphotransferase AK3, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03169}",null,"AK3"]
["18.756","18.612","19.1845","18.8004",{"$nulls":3},"cellular metabolic process",{"$nulls":5},2,2,2,"11.4","11.4","11.4","22.287",0,"4.0226",55522000,7,"0.566275","0.469738","-0.30846","-1.50405","tr|F5H0D0|F5H0D0_HUMAN;sp|Q14232|EI2BA_HUMAN;tr|H0YGG4|H0YGG4_HUMAN","tr|F5H0D0|F5H0D0_HUMAN;sp|Q14232|EI2BA_HUMAN;tr|H0YGG4|H0YGG4_HUMAN",1613,"F5H0D0","F5H0D0_HUMAN",null,null,"EIF2B1"]
["19.0301","18.6481","19.4431","18.853",{"$nulls":9},1,1,1,"8.4","8.4","8.4","17.617",0,"5.379",16582000,6,"0.325974","0.705459","-0.308943","-0.879046","tr|H3BSK4|H3BSK4_HUMAN;tr|H3BNB9|H3BNB9_HUMAN;sp|Q9Y4X5|ARI1_HUMAN","tr|H3BSK4|H3BSK4_HUMAN;tr|H3BNB9|H3BNB9_HUMAN;sp|Q9Y4X5|ARI1_HUMAN",3008,"H3BSK4","H3BSK4_HUMAN",null,null,"ARIH1"]
["23.9863","23.88","24.2733","24.2116",{"$nulls":3},"ATP synthesis coupled proton transport","hydrogen ion transmembrane transporter activity","mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);mitochondrion",{"$nulls":3},3,3,3,"48.7","48.7","48.7","8.4518",0,"57.051",600910000,16,"1.42827","0.33516","-0.309331","-5.03167","tr|E9PN17|E9PN17_HUMAN;sp|O75964|ATP5L_HUMAN","tr|E9PN17|E9PN17_HUMAN;sp|O75964|ATP5L_HUMAN",381,"E9PN17","E9PN17_HUMAN",null,null,"ATP5MG"]
["18.7584","18.53","19.6933","18.2146",{"$nulls":4},"lipid binding","integral component of membrane",{"$nulls":3},8,8,8,"11.7","11.7","11.7","98.008",0,"16.737",238820000,25,"0.143261","0.882687","-0.309772","-0.414051","tr|H7BXI1|H7BXI1_HUMAN;tr|A0A087WXU3|A0A087WXU3_HUMAN;sp|A0FGR8|ESYT2_HUMAN","tr|H7BXI1|H7BXI1_HUMAN;tr|A0A087WXU3|A0A087WXU3_HUMAN;sp|A0FGR8|ESYT2_HUMAN",94,"H7BXI1","H7BXI1_HUMAN",null,null,"ESYT2"]
["21.2883","20.7157","21.4478","21.1764",{"$nulls":3},"histidyl-tRNA aminoacylation","ATP binding;histidine-tRNA ligase activity","cytoplasm",{"$nulls":3},7,7,4,"17.5","17.5","11.1","49.623",0,"49.199",644230000,27,"0.365648","0.663698","-0.31015","-0.978854","tr|B3KWE1|B3KWE1_HUMAN;sp|P12081|SYHC_HUMAN;tr|B4E1C5|B4E1C5_HUMAN;tr|B4DDD8|B4DDD8_HUMAN;tr|E7ETE2|E7ETE2_HUMAN","tr|B3KWE1|B3KWE1_HUMAN;sp|P12081|SYHC_HUMAN;tr|B4E1C5|B4E1C5_HUMAN;tr|B4DDD8|B4DDD8_HUMAN;tr|E7ETE2|E7ETE2_HUMAN",640,"B3KWE1","B3KWE1_HUMAN"]
["18.8157","18.6508","19.0563","19.031",{"$nulls":9},1,1,1,"6.9","6.9","6.9","17.996",0,"5.7169",46330000,9,"1.18586","0.322639","-0.310416","-3.72264","tr|E9PLS4|E9PLS4_HUMAN;tr|E9PMM3|E9PMM3_HUMAN;tr|E9PP98|E9PP98_HUMAN;sp|Q9Y5Y5|PEX16_HUMAN","tr|E9PLS4|E9PLS4_HUMAN;tr|E9PMM3|E9PMM3_HUMAN;tr|E9PP98|E9PP98_HUMAN;sp|Q9Y5Y5|PEX16_HUMAN",3033,"E9PLS4","E9PLS4_HUMAN",null,null,"PEX16"]
["21.0259","21.3263","21.8839","21.0895",{"$nulls":3},"protein deneddylation",null,"COP9 signalosome",{"$nulls":3},11,11,11,"25.1","25.1","25.1","53.371",0,"78.39",506800000,38,"0.267059","0.755653","-0.310538","-0.731282","tr|C9JFE4|C9JFE4_HUMAN;sp|Q13098|CSN1_HUMAN;tr|A0A096LP07|A0A096LP07_HUMAN;tr|A0A096LPJ3|A0A096LPJ3_HUMAN;tr|A8K070|A8K070_HUMAN;tr|J3QQX0|J3QQX0_HUMAN;tr|J3QS88|J3QS88_HUMAN;tr|J3KTB0|J3KTB0_HUMAN;tr|J3QLT0|J3QLT0_HUMAN;tr|J3KSA5|J3KSA5_HUMAN;tr|J3KRJ4|J3KRJ4_HUMAN","tr|C9JFE4|C9JFE4_HUMAN;sp|Q13098|CSN1_HUMAN;tr|A0A096LP07|A0A096LP07_HUMAN;tr|A0A096LPJ3|A0A096LPJ3_HUMAN;tr|A8K070|A8K070_HUMAN",1519,"C9JFE4","C9JFE4_HUMAN"]
["21.1349","21.0404","21.2701","21.5263",{"$nulls":9},2,2,2,"37.3","37.3","37.3","8.3713",0,"6.5412",121990000,16,"0.821803","0.321722","-0.310577","-2.2749","tr|I3L0K2|I3L0K2_HUMAN;tr|I3L3M7|I3L3M7_HUMAN;sp|Q9BRA2|TXD17_HUMAN;tr|I3L2R6|I3L2R6_HUMAN","tr|I3L0K2|I3L0K2_HUMAN;tr|I3L3M7|I3L3M7_HUMAN;sp|Q9BRA2|TXD17_HUMAN;tr|I3L2R6|I3L2R6_HUMAN",2424,"I3L0K2","I3L0K2_HUMAN",null,null,"TXNDC17"]
["14.0286","13.9534","14.8435","13.7603",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process;clathrin coat assembly;clathrin-dependent endocytosis;digestive system development;membrane organization;negative regulation of actin filament polymerization;negative regulation of apoptotic process;negative regulation of Arp2/3 complex-mediated actin nucleation;positive regulation of apoptotic process;positive regulation of clathrin coat assembly;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of platelet-derived growth factor receptor-beta signaling pathway;positive regulation of protein binding;protein stabilization;receptor-mediated endocytosis;regulation of actin cytoskeleton organization;regulation of clathrin-dependent endocytosis;regulation of endocytosis;regulation of gastric acid secretion","actin filament binding;clathrin adaptor activity;clathrin binding;clathrin light chain binding;identical protein binding;phosphatidylinositol binding;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-4,5-bisphosphate binding;protein heterodimerization activity;protein homodimerization activity;SH3 domain binding","apical plasma membrane;cell cortex;clathrin-coated pit;clathrin-coated vesicle;clathrin-coated vesicle membrane;cytoskeleton;cytosol;dendrite cytoplasm;dendritic spine;intracellular membrane-bounded organelle;mitochondrion;neuronal cell body;perinuclear region of cytoplasm;postsynaptic density;ruffle membrane;synaptic membrane",{"$nulls":3},1,1,1,"1.3","1.3","1.3","119.39",0,"3.6626",10598000,5,"0.204364","0.817811","-0.310929","-0.572702","sp|O75146|HIP1R_HUMAN","sp|O75146|HIP1R_HUMAN",321,"O75146","HIP1R_HUMAN","Huntingtin-interacting protein 1-related protein","IP1-related protein","HIP1R"]
["23.1433","23.0687","23.638","23.196",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;cell cycle;cellular response to glucose stimulus;cellular response to growth factor stimulus;gastrulation;negative regulation of cell growth;negative regulation of endoplasmic reticulum unfolded protein response;negative regulation of gene expression;negative regulation of hydrogen peroxide-induced neuron death;negative regulation of peptidyl-serine phosphorylation;negative regulation of phagocytosis;negative regulation of protein kinase B signaling;negative regulation of translation;negative regulation of Wnt signaling pathway;pigmentation;positive regulation of apoptotic process;positive regulation of cAMP catabolic process;positive regulation of cell migration;positive regulation of ceramide biosynthetic process;positive regulation of cyclic-nucleotide phosphodiesterase activity;positive regulation of gastrulation;positive regulation of Golgi to plasma membrane protein transport;positive regulation of GTPase activity;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial depolarization;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein homooligomerization;positive regulation of protein phosphorylation;protein ubiquitination;regulation of cell cycle;regulation of cell division;regulation of establishment of cell polarity;regulation of protein localization;regulation of tumor necrosis factor-mediated signaling pathway;rescue of stalled ribosome;rhythmic process;viral process","cadherin binding;cyclin binding;cysteine-type endopeptidase activator activity involved in apoptotic process;enzyme binding;ion channel inhibitor activity;protein complex scaffold activity;protein homodimerization activity;protein kinase C binding;protein phosphatase binding;protein tyrosine kinase inhibitor activity;receptor binding;receptor tyrosine kinase binding;ribosome binding;RNA binding;SH2 domain binding;signaling adaptor activity","cytoplasm;cytosol;dendrite;extracellular exosome;IRE1-RACK1-PP2A complex;midbody;mitochondrion;neuronal cell body;nucleoplasm;nucleus;perikaryon;perinuclear region of cytoplasm;phagocytic cup;small ribosomal subunit","Measles",null,null,11,11,11,"50.8","50.8","50.8","35.076",0,"88.487",2101800000,58,"0.523383","0.502479","-0.311007","-1.38756","sp|P63244|GBLP_HUMAN;tr|D6RAC2|D6RAC2_HUMAN;tr|J3KPE3|J3KPE3_HUMAN;tr|D6RHH4|D6RHH4_HUMAN;tr|D6RFX4|D6RFX4_HUMAN;tr|H0YAF8|H0YAF8_HUMAN;tr|D6R9Z1|D6R9Z1_HUMAN;tr|D6R9L0|D6R9L0_HUMAN;tr|D6REE5|D6REE5_HUMAN;tr|H0Y8W2|H0Y8W2_HUMAN;tr|D6RAU2|D6RAU2_HUMAN;tr|E9PD14|E9PD14_HUMAN;tr|D6RFZ9|D6RFZ9_HUMAN;tr|H0YAM7|H0YAM7_HUMAN;tr|H0Y8R5|H0Y8R5_HUMAN;tr|D6RBD0|D6RBD0_HUMAN;tr|D6RGK8|D6RGK8_HUMAN;tr|D6RHJ5|D6RHJ5_HUMAN;tr|D6RF23|D6RF23_HUMAN;tr|D6R909|D6R909_HUMAN;tr|D6RDI0|D6RDI0_HUMAN;tr|H0Y9P0|H0Y9P0_HUMAN","sp|P63244|GBLP_HUMAN;tr|D6RAC2|D6RAC2_HUMAN;tr|J3KPE3|J3KPE3_HUMAN;tr|D6RHH4|D6RHH4_HUMAN;tr|D6RFX4|D6RFX4_HUMAN;tr|H0YAF8|H0YAF8_HUMAN;tr|D6R9Z1|D6R9Z1_HUMAN;tr|D6R9L0|D6R9L0_HUMAN;tr|D6REE5|D6REE5_HUMAN;tr|H0Y8W2|H0Y8W2_HUMAN",1348,"P63244","RACK1_HUMAN","Receptor of activated protein C kinase 1",null,"RACK1"]
["21.0589","20.9043","21.369","21.217",{"$nulls":3},"activation of MAPK activity;cell differentiation;Fc-epsilon receptor signaling pathway;JNK cascade;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription, DNA-templated;postreplication repair;protein K63-linked ubiquitination;protein polyubiquitination;regulation of DNA repair;regulation of transcription, DNA-templated;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway","ubiquitin protein ligase activity;ubiquitin protein ligase binding","cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;protein complex;UBC13-UEV1A complex;ubiquitin conjugating enzyme complex;ubiquitin ligase complex",{"$nulls":3},6,2,2,"43.5",17,17,"16.495",0,"4.7006",233800000,10,"0.987814","0.297606","-0.311423","-2.87235","sp|Q13404|UB2V1_HUMAN;tr|I3L0A0|I3L0A0_HUMAN;tr|A0A0A0MSL3|A0A0A0MSL3_HUMAN;tr|G3V2F7|G3V2F7_HUMAN","sp|Q13404|UB2V1_HUMAN;tr|I3L0A0|I3L0A0_HUMAN;tr|A0A0A0MSL3|A0A0A0MSL3_HUMAN;tr|G3V2F7|G3V2F7_HUMAN",1547,"Q13404","UB2V1_HUMAN","Ubiquitin-conjugating enzyme E2 variant 1","EV-1","UBE2V1"]
["16.1329","18.2565","17.6976","17.3155",{"$nulls":3},"cellular response to amino acid stimulus;covalent chromatin modification;DNA methylation;DNA methylation involved in embryo development;gene silencing;maintenance of DNA methylation;negative regulation of gene expression, epigenetic;negative regulation of histone H3-K9 methylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of gene expression;positive regulation of histone H3-K4 methylation;positive regulation of methylation-dependent chromatin silencing;Ras protein signal transduction;regulation of cell proliferation;transcription, DNA-templated","DNA (cytosine-5-)-methyltransferase activity;DNA binding;DNA-methyltransferase activity;methyl-CpG binding;promoter-specific chromatin binding;RNA binding;zinc ion binding","nucleoplasm;nucleus;pericentric heterochromatin;replication fork","Cysteine and methionine metabolism;Metabolic pathways;MicroRNAs in cancer",null,null,13,13,13,"10.4","10.4","10.4","183.16",0,"32.017",261620000,29,"0.0970491","0.91641","-0.311848","-0.28906","sp|P26358|DNMT1_HUMAN;tr|K7EJL0|K7EJL0_HUMAN;tr|K7ENW7|K7ENW7_HUMAN;tr|K7EIZ6|K7EIZ6_HUMAN;tr|K7EMU8|K7EMU8_HUMAN;tr|K7ENQ6|K7ENQ6_HUMAN","sp|P26358|DNMT1_HUMAN",808,"P26358","DNMT1_HUMAN","DNA (cytosine-5)-methyltransferase 1","nmt1","DNMT1"]
["21.0299","20.95","21.9927","20.6114",{"$nulls":9},4,4,4,"35.9","35.9","35.9","21.883",0,"10.729",157360000,21,"0.157344","0.867885","-0.312093","-0.451157","tr|C9JQV0|C9JQV0_HUMAN;sp|Q9BRJ6|CG050_HUMAN;tr|H7C0T1|H7C0T1_HUMAN;tr|H7C2R9|H7C2R9_HUMAN","tr|C9JQV0|C9JQV0_HUMAN;sp|Q9BRJ6|CG050_HUMAN;tr|H7C0T1|H7C0T1_HUMAN;tr|H7C2R9|H7C2R9_HUMAN",2426,"C9JQV0","C9JQV0_HUMAN",null,null,"C7orf50"]
["15.6562",1,"16.2807",1,{"$nulls":3},"cytoplasmic microtubule organization;cytoskeleton-dependent intracellular transport;early endosome to late endosome transport;endosome organization;endosome to lysosome transport;lysosome organization;multicellular organism development;protein transport;spermatid development","actin binding;dynein light intermediate chain binding;identical protein binding;microtubule binding","centrosome;cytosol;FHF complex;microtubule",{"$nulls":3},1,1,1,"1.4","1.4","1.4","84.647","0.0011215","2.7824",19074000,3,"0.00915122","0.984103","-0.312243","-0.0294942","sp|Q9UJC3|HOOK1_HUMAN","sp|Q9UJC3|HOOK1_HUMAN",2856,"Q9UJC3","HOOK1_HUMAN","Protein Hook homolog 1","HK1;-hook1","HOOK1"]
["21.8733","21.7493","22.5536","21.6943",{"$nulls":4},"translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex",{"$nulls":3},8,8,8,"31.7","31.7","31.7","29.283",0,"69.124",690310000,47,"0.262683","0.759458","-0.312673","-0.720285","tr|K7EL20|K7EL20_HUMAN;sp|O75821|EIF3G_HUMAN;tr|K7ER90|K7ER90_HUMAN;tr|K7ENA8|K7ENA8_HUMAN;tr|K7EP16|K7EP16_HUMAN;tr|K7EL60|K7EL60_HUMAN;tr|K7ENH0|K7ENH0_HUMAN","tr|K7EL20|K7EL20_HUMAN;sp|O75821|EIF3G_HUMAN;tr|K7ER90|K7ER90_HUMAN;tr|K7ENA8|K7ENA8_HUMAN",367,"K7EL20","K7EL20_HUMAN",null,null,"EIF3G"]
["17.2345","17.3208","17.6776","17.5048",{"$nulls":3},"cell proliferation;cellular response to dexamethasone stimulus;cellular response to nerve growth factor stimulus;endosome organization;mitotic cytokinesis;positive regulation of canonical Wnt signaling pathway;protein deubiquitination;protein K48-linked deubiquitination;protein K63-linked deubiquitination;ubiquitin-dependent protein catabolic process","cadherin binding;cysteine-type endopeptidase activity;SH3 domain binding;thiol-dependent ubiquitin-specific protease activity","cytoplasm;cytosol;dendritic spine;early endosome;extrinsic component of endosome membrane;extrinsic component of plasma membrane;midbody;nucleus;postsynaptic density","Cushing syndrome;Endocytosis;Mitophagy - animal",null,null,2,2,2,"3.1","3.1","3.1","127.52",0,"41.174",95440000,6,"1.07983","0.30652","-0.313545","-3.24648","sp|P40818|UBP8_HUMAN","sp|P40818|UBP8_HUMAN",974,"P40818","UBP8_HUMAN","Ubiquitin carboxyl-terminal hydrolase 8",null,"USP8"]
["19.9555","19.7173","20.3627","19.9391",{"$nulls":3},"small GTPase mediated signal transduction","GTP binding","intracellular",{"$nulls":3},3,2,2,"28.7","14.7","14.7","17.107",0,"10.964",133020000,8,"0.488266","0.523414","-0.314502","-1.2942","tr|C9J1Z8|C9J1Z8_HUMAN;sp|P84085|ARF5_HUMAN","tr|C9J1Z8|C9J1Z8_HUMAN;sp|P84085|ARF5_HUMAN",1390,"C9J1Z8","C9J1Z8_HUMAN",null,null,"ARF5"]
["20.6413","20.5522","21.3348","20.4877",{"$nulls":3},"cell redox homeostasis;glycoprotein metabolic process;neutrophil degranulation;protein folding;response to endoplasmic reticulum stress;response to unfolded protein","protein disulfide isomerase activity","cell surface;endoplasmic reticulum lumen;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular region;specific granule lumen",{"$nulls":3},8,8,8,"25.9","25.9","25.9","46.971",0,"115.68",418160000,27,"0.269924","0.757533","-0.31453","-0.738476","sp|Q9BS26|ERP44_HUMAN","sp|Q9BS26|ERP44_HUMAN",2433,"Q9BS26","ERP44_HUMAN","Endoplasmic reticulum resident protein 44","R protein 44;Rp44","ERP44"]
["22.0551","21.7185","22.5106","21.8923",{"$nulls":4},"cadherin binding;RNA binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;mitochondrial nucleoid;nuclear envelope;organelle membrane",{"$nulls":3},6,6,6,"28.7","28.7","28.7","34.93",0,"12.884",566510000,18,"0.331894","0.702805","-0.314647","-0.893907","sp|Q96AG4|LRC59_HUMAN;tr|I3L223|I3L223_HUMAN","sp|Q96AG4|LRC59_HUMAN",2232,"Q96AG4","LRC59_HUMAN","Leucine-rich repeat-containing protein 59",null,"LRRC59"]
["22.4031","22.25","22.9682","22.3143",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;autophagy;cell division;clathrin coat assembly;clathrin-dependent endocytosis;intracellular protein transport;low-density lipoprotein particle clearance;low-density lipoprotein particle receptor catabolic process;membrane organization;microtubule-based movement;mitotic cell cycle;negative regulation of hyaluronan biosynthetic process;negative regulation of protein localization to plasma membrane;osteoblast differentiation;receptor internalization;receptor-mediated endocytosis;regulation of mitotic spindle organization;retrograde transport, endosome to Golgi;transcytosis;transferrin transport;Wnt signaling pathway, planar cell polarity pathway","clathrin light chain binding;disordered domain specific binding;double-stranded RNA binding;low-density lipoprotein particle receptor binding;protein kinase binding;RNA binding;structural molecule activity;ubiquitin-specific protease binding","clathrin coat;clathrin coat of coated pit;clathrin coat of trans-Golgi network vesicle;clathrin complex;clathrin-coated endocytic vesicle;clathrin-coated endocytic vesicle membrane;clathrin-coated vesicle;cytosol;endolysosome membrane;endosome;extracellular exosome;extracellular matrix;extracellular vesicle;focal adhesion;lysosome;melanosome;membrane;mitotic spindle microtubule;plasma membrane;protein complex;spindle;trans-Golgi network membrane","Bacterial invasion of epithelial cells;Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Huntington disease;Lysosome;Synaptic vesicle cycle",null,null,38,38,38,"33.5","33.5","33.5","191.61",0,"323.31",6402100000,261,"0.34913","0.686802","-0.314679","-0.937228","sp|Q00610|CLH1_HUMAN;tr|A0A087WVQ6|A0A087WVQ6_HUMAN;tr|J3KS13|J3KS13_HUMAN;tr|A0A087WX41|A0A087WX41_HUMAN;sp|P53675|CLH2_HUMAN;tr|K7EJJ5|K7EJJ5_HUMAN;tr|J3QL20|J3QL20_HUMAN;tr|J3KSQ2|J3KSQ2_HUMAN;tr|J3KRF5|J3KRF5_HUMAN","sp|Q00610|CLH1_HUMAN;tr|A0A087WVQ6|A0A087WVQ6_HUMAN",1406,"Q00610","CLH1_HUMAN","Clathrin heavy chain 1",null,"CLTC"]
["25.4367","25.2393","25.6595","25.6465",{"$nulls":3},"anterograde axonal protein transport;cellular response to vascular endothelial growth factor stimulus;chaperone-mediated protein folding;intracellular signal transduction;movement of cell or subcellular component;negative regulation of apoptotic process;negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;negative regulation of protein kinase activity;platelet aggregation;positive regulation of angiogenesis;positive regulation of blood vessel endothelial cell migration;positive regulation of endothelial cell chemotaxis;positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;positive regulation of interleukin-1 beta production;positive regulation of tumor necrosis factor biosynthetic process;regulation of autophagy;regulation of I-kappaB kinase/NF-kappaB signaling;regulation of mRNA stability;regulation of protein phosphorylation;regulation of translational initiation;response to unfolded protein;response to virus;retina homeostasis;vascular endothelial growth factor receptor signaling pathway","identical protein binding;protein binding involved in protein folding;protein homodimerization activity;protein kinase binding;protein kinase C binding;protein kinase C inhibitor activity;RNA binding;ubiquitin binding","axon cytoplasm;cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular matrix;extracellular space;focal adhesion;nucleus;plasma membrane;proteasome complex;spindle;Z disc","Amoebiasis;MAPK signaling pathway;VEGF signaling pathway",null,null,10,10,10,"70.2","70.2","70.2","22.782",0,"323.31",6046700000,129,"1.06545","0.305075","-0.315027","-3.18575","sp|P04792|HSPB1_HUMAN;tr|F8WE04|F8WE04_HUMAN;tr|C9J3N8|C9J3N8_HUMAN","sp|P04792|HSPB1_HUMAN",501,"P04792","HSPB1_HUMAN","Heat shock protein beta-1","spB1","HSPB1"]
["20.5714","20.4346","21.0425","20.5945",{"$nulls":3},"cellular response to epidermal growth factor stimulus;cellular response to insulin stimulus;cellular response to platelet-derived growth factor stimulus;cellular response to starvation;methionyl-tRNA aminoacylation;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;rRNA transcription;tRNA aminoacylation for protein translation","ATP binding;methionine-tRNA ligase activity;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;extracellular exosome;membrane;nucleolus","Aminoacyl-tRNA biosynthesis;Metabolic pathways;Selenocompound metabolism",null,null,10,10,10,"16.9","16.9","16.9","101.11",0,"102.78",743790000,48,"0.508187","0.514207","-0.315454","-1.34695","sp|P56192|SYMC_HUMAN;tr|H0YIP0|H0YIP0_HUMAN;tr|H0YI94|H0YI94_HUMAN;tr|H0YHL6|H0YHL6_HUMAN;tr|H0YI27|H0YI27_HUMAN;tr|H0YHV5|H0YHV5_HUMAN","sp|P56192|SYMC_HUMAN;tr|H0YIP0|H0YIP0_HUMAN",1220,"P56192","SYMC_HUMAN","Methionine--tRNA ligase, cytoplasmic",null,"MARS"]
["23.6959","23.3878","24.1017","23.613",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},8,8,8,50,50,50,"13.997",0,"10.448",1386700000,33,"0.410301","0.608143","-0.315483","-1.09217","tr|M0QZC5|M0QZC5_HUMAN;sp|P62280|RS11_HUMAN;tr|M0R1H6|M0R1H6_HUMAN;tr|M0R1H5|M0R1H5_HUMAN","tr|M0QZC5|M0QZC5_HUMAN;sp|P62280|RS11_HUMAN",1301,"M0QZC5","M0QZC5_HUMAN",null,null,"RPS11"]
["15.6051","15.5389","16.2473","15.5281",{"$nulls":3},"biotin metabolic process;gluconeogenesis;lipid metabolic process;negative regulation of gene expression;positive regulation by host of viral process;positive regulation by host of viral release from host cell;pyruvate metabolic process;viral RNA genome packaging","ATP binding;biotin binding;biotin carboxylase activity;identical protein binding;metal ion binding;pyruvate carboxylase activity","cytoplasm;cytosol;mitochondrial matrix;mitochondrion","Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways;Pyruvate metabolism",null,null,2,2,2,"2.6","2.6","2.6","129.63",0,"5.0168",37263000,6,"0.324075","0.708928","-0.315713","-0.874283","sp|P11498|PYC_HUMAN;tr|E9PS68|E9PS68_HUMAN","sp|P11498|PYC_HUMAN;tr|E9PS68|E9PS68_HUMAN",633,"P11498","PYC_HUMAN","Pyruvate carboxylase, mitochondrial",null,"PC"]
["17.3286","17.5851","18.1821","17.3636",{"$nulls":3},"brain development;cellular response to heat;cellular response to mechanical stimulus;extrinsic apoptotic signaling pathway in absence of ligand;extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of apoptotic process;negative regulation of striated muscle cell apoptotic process;negative regulation of transcription from RNA polymerase II promoter in response to stress;positive regulation of protein export from nucleus;positive regulation of transcription factor import into nucleus;protein folding;protein stabilization;regulation of cellular response to heat;spinal cord development","adenyl-nucleotide exchange factor activity;cadherin binding;chaperone binding;protein complex binding","cytoplasm;cytosol;neuron projection;nucleus;plasma membrane;Z disc",{"$nulls":3},3,3,3,"8.7","8.7","8.7","61.594",0,"7.2026",60015000,8,"0.269276","0.756527","-0.316012","-0.736848","sp|O95817|BAG3_HUMAN;tr|C9JFK9|C9JFK9_HUMAN","sp|O95817|BAG3_HUMAN;tr|C9JFK9|C9JFK9_HUMAN",451,"O95817","BAG3_HUMAN","BAG family molecular chaperone regulator 3","AG-3","BAG3"]
["17.651","18.1858","18.2818","18.1876",{"$nulls":3},"cell division;cytoskeleton-dependent intracellular transport;microtubule-based process","GTP binding;GTPase activity;structural constituent of cytoskeleton;structural molecule activity","cytoplasm;microtubule;microtubule cytoskeleton;nucleus;vesicle","Apoptosis;Gap junction;Pathogenic Escherichia coli infection;Phagosome;Tight junction",null,null,21,3,3,"58.1","13.4","13.4","49.895",0,"6.8134",59611000,18,"0.438663","0.566528","-0.316302","-1.16494","sp|Q9BQE3|TBA1C_HUMAN;tr|F5H5D3|F5H5D3_HUMAN;tr|F8VVB9|F8VVB9_HUMAN;tr|F8VRZ4|F8VRZ4_HUMAN;tr|F8VS66|F8VS66_HUMAN;tr|F8VWV9|F8VWV9_HUMAN;tr|F8VX09|F8VX09_HUMAN;tr|C9K0S6|C9K0S6_HUMAN;tr|F8VRK0|F8VRK0_HUMAN;sp|Q9H853|TBA4B_HUMAN;sp|A6NHL2|TBAL3_HUMAN;tr|F8VXZ7|F8VXZ7_HUMAN;tr|F8W0F6|F8W0F6_HUMAN","sp|Q9BQE3|TBA1C_HUMAN;tr|F5H5D3|F5H5D3_HUMAN;tr|F8VVB9|F8VVB9_HUMAN",2418,"Q9BQE3","TBA1C_HUMAN","Tubulin alpha-1C chain",null,"TUBA1C"]
["14.9754","15.0768","16.9007","13.7851",{"$nulls":3},"protein deubiquitination;spliceosomal complex assembly","thiol-dependent ubiquitinyl hydrolase activity;zinc ion binding","nucleoplasm",{"$nulls":3},2,2,2,"6.8","6.8","6.8","56.399","0.00039936","3.3502",18535000,3,"0.0666503","0.934975","-0.316813","-0.20327","tr|A0A087X1B2|A0A087X1B2_HUMAN;tr|B9A018|B9A018_HUMAN;sp|Q53GS9|SNUT2_HUMAN;tr|A0A087WW31|A0A087WW31_HUMAN","tr|A0A087X1B2|A0A087X1B2_HUMAN;tr|B9A018|B9A018_HUMAN;sp|Q53GS9|SNUT2_HUMAN;tr|A0A087WW31|A0A087WW31_HUMAN",1795,"A0A087X1B2","A0A087X1B2_HUMAN",null,null,"USP39"]
["17.0958","18.3027","17.8648","18.1675",{"$nulls":4},"calcium ion binding",{"$nulls":4},3,3,3,"9.2","9.2","9.2","49.856",0,"14.193",63060000,12,"0.179681","0.839824","-0.31686","-0.509289","tr|M0R2S2|M0R2S2_HUMAN;tr|M0R165|M0R165_HUMAN;sp|Q9UBC2|EP15R_HUMAN","tr|M0R2S2|M0R2S2_HUMAN;tr|M0R165|M0R165_HUMAN;sp|Q9UBC2|EP15R_HUMAN",2798,"M0R2S2","M0R2S2_HUMAN",null,null,"EPS15L1"]
["15.5843","15.4652","15.8907","15.7954",{"$nulls":3},"tRNA splicing, via endonucleolytic cleavage and ligation","tRNA-intron endonuclease activity","centrosome;cytosol;nucleoplasm;tRNA-intron endonuclease complex",{"$nulls":3},1,1,1,"2.9","2.9","2.9","43.174","0.0031099","2.1461",10061000,1,"1.27657","0.326938","-0.318269","-4.1735","tr|C9J7Z4|C9J7Z4_HUMAN;sp|Q8NCE0|SEN2_HUMAN","tr|C9J7Z4|C9J7Z4_HUMAN;sp|Q8NCE0|SEN2_HUMAN",2082,"C9J7Z4","C9J7Z4_HUMAN",null,null,"TSEN2"]
["15.7531","15.4626","16.3881","15.4652",{"$nulls":4},"actin binding;ATP binding;motor activity","myosin complex",{"$nulls":3},3,3,3,"2.2","2.2","2.2","212.2",0,"15.19",44203000,12,"0.238378","0.787513","-0.318808","-0.659056","tr|A0A087WY00|A0A087WY00_HUMAN;tr|G3V394|G3V394_HUMAN;tr|F8WE88|F8WE88_HUMAN;tr|F8W6H6|F8W6H6_HUMAN;sp|Q9Y4I1|MYO5A_HUMAN;tr|H0YM93|H0YM93_HUMAN;tr|H0YMK3|H0YMK3_HUMAN;tr|E7ERV5|E7ERV5_HUMAN;tr|Q7Z7A5|Q7Z7A5_HUMAN;sp|Q9NQX4|MYO5C_HUMAN;sp|Q9ULV0|MYO5B_HUMAN","tr|A0A087WY00|A0A087WY00_HUMAN;tr|G3V394|G3V394_HUMAN;tr|F8WE88|F8WE88_HUMAN;tr|F8W6H6|F8W6H6_HUMAN;sp|Q9Y4I1|MYO5A_HUMAN",3001,"A0A087WY00","A0A087WY00_HUMAN",null,null,"MYO5A"]
["16.0335","16.0464","16.4473","16.2719",{"$nulls":3},"chromatin maintenance;chromatin remodeling;chromatin silencing;mRNA processing;mRNA transcription from RNA polymerase II promoter;mRNA transport;negative regulation of histone H3-K27 methylation;nucleosome organization;positive regulation of transcription elongation from RNA polymerase II promoter;regulation of isotype switching;regulation of mRNA export from nucleus;regulation of mRNA processing;regulation of muscle cell differentiation;regulation of transcription, DNA-templated;RNA splicing;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;viral process","DNA binding;DNA binding transcription factor activity;histone binding;nucleosome binding;RNA binding;transcription factor activity, core RNA polymerase II binding","nucleoplasm;nucleus;transcription elongation factor complex;transcriptionally active chromatin",{"$nulls":3},6,6,6,"7.4","7.4","7.4","199.07",0,"8.8646",63238000,7,"1.16706","0.318416","-0.319672","-3.6344","sp|Q7KZ85|SPT6H_HUMAN","sp|Q7KZ85|SPT6H_HUMAN",1927,"Q7KZ85","SPT6H_HUMAN","Transcription elongation factor SPT6","SPT6","SUPT6H"]
["27.413","27.154","27.7775","27.4293",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;canonical glycolysis;cellular response to interferon-gamma;defense response to fungus;gluconeogenesis;killing by host of symbiont cells;killing of cells of other organism;microtubule cytoskeleton organization;negative regulation of endopeptidase activity;negative regulation of translation;neuron apoptotic process;peptidyl-cysteine S-trans-nitrosylation;positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction;positive regulation of cytokine secretion;protein stabilization;regulation of macroautophagy","aspartic-type endopeptidase inhibitor activity;disordered domain specific binding;glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;identical protein binding;microtubule binding;NAD binding;NADP binding;peptidyl-cysteine S-nitrosylase activity","cytoplasm;cytosol;extracellular exosome;extracellular matrix;GAIT complex;intracellular membrane-bounded organelle;intracellular ribonucleoprotein complex;lipid droplet;membrane;microtubule cytoskeleton;nuclear membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;vesicle","Alzheimer disease;Biosynthesis of amino acids;Carbon metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways",null,null,21,21,21,"82.1","82.1","82.1","36.053",0,"323.31",34905000000,395,"0.55556","0.472317","-0.319924","-1.47467","sp|P04406|G3P_HUMAN;tr|E7EUT5|E7EUT5_HUMAN;sp|O14556|G3PT_HUMAN","sp|P04406|G3P_HUMAN;tr|E7EUT5|E7EUT5_HUMAN",497,"P04406","G3P_HUMAN","Glyceraldehyde-3-phosphate dehydrogenase","APDH","GAPDH"]
["18.2688",1,1,"18.9089",{"$nulls":3},"melanin biosynthetic process;negative regulation of macrophage chemotaxis;positive regulation of ERK1 and ERK2 cascade;positive regulation of inflammatory response;positive regulation of tumor necrosis factor production","cytokine receptor binding;D-dopachrome decarboxylase activity;dopachrome isomerase activity;phenylpyruvate tautomerase activity","cytoplasm;extracellular exosome;extracellular space",{"$nulls":3},2,2,2,"17.8","17.8","17.8","12.712",0,"4.9566",21268000,3,"0.00797162","0.983499","-0.32001","-0.0257258","sp|P30046|DOPD_HUMAN;sp|A6NHG4|DDTL_HUMAN;tr|B5MC82|B5MC82_HUMAN;tr|J3KQ18|J3KQ18_HUMAN","sp|P30046|DOPD_HUMAN;sp|A6NHG4|DDTL_HUMAN;tr|B5MC82|B5MC82_HUMAN;tr|J3KQ18|J3KQ18_HUMAN",104,"P30046","DOPD_HUMAN","D-dopachrome decarboxylase",null,"DDT"]
["18.8679","19.4043","20.0355","18.8774",{"$nulls":3},"negative regulation of transcription, DNA-templated;positive regulation of abscisic acid-activated signaling pathway","ATP binding;GTP binding;phosphatidylinositol-3-phosphate binding;phosphatidylinositol-4-phosphate binding;phosphatidylinositol-5-phosphate binding","cortical actin cytoskeleton;cytosol;nucleus;plasma membrane",{"$nulls":3},4,4,4,"10.9","10.9","10.9","50.854",0,"9.3353",170930000,11,"0.176881","0.842735","-0.320369","-0.502044","sp|Q9NS86|LANC2_HUMAN","sp|Q9NS86|LANC2_HUMAN",2691,"Q9NS86","LANC2_HUMAN","LanC-like protein 2",null,"LANCL2"]
["19.3824","19.2272","19.9505","19.3",{"$nulls":3},"'de novo' posttranslational protein folding;endoplasmic reticulum mannose trimming;endoplasmic reticulum unfolded protein response;ER-associated misfolded protein catabolic process;protein N-linked glycosylation via asparagine","UDP-glucose:glycoprotein glucosyltransferase activity;unfolded protein binding","endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum quality control compartment;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;protein complex","Protein processing in endoplasmic reticulum",null,null,15,15,15,"16.3","16.3","16.3","177.19",0,"73.944",568860000,62,"0.357457","0.675173","-0.320398","-0.958196","sp|Q9NYU2|UGGG1_HUMAN;tr|F8WCI2|F8WCI2_HUMAN;tr|F8WCE6|F8WCE6_HUMAN;tr|H7BZG0|H7BZG0_HUMAN","sp|Q9NYU2|UGGG1_HUMAN",2752,"Q9NYU2","UGGG1_HUMAN","UDP-glucose:glycoprotein glucosyltransferase 1","GT1;UGT1","UGGT1"]
["21.7218","21.7149","21.8529","22.2254",{"$nulls":3},"antigen processing and presentation of peptide antigen via MHC class I;immune response",null,"extracellular region;MHC class I protein complex",{"$nulls":3},2,2,2,"28.2","28.2","28.2","8.4984",0,"9.6703",146130000,11,"0.643663","0.400771","-0.320785","-1.72226","tr|H0YLF3|H0YLF3_HUMAN;tr|F5H6I0|F5H6I0_HUMAN;sp|P61769|B2MG_HUMAN;tr|H0YL18|H0YL18_HUMAN","tr|H0YLF3|H0YLF3_HUMAN;tr|F5H6I0|F5H6I0_HUMAN;sp|P61769|B2MG_HUMAN;tr|H0YL18|H0YL18_HUMAN",1280,"H0YLF3","H0YLF3_HUMAN","Beta-2-microglobulin {ECO:0000256|SAAS:SAAS00327869}",null,"B2M"]
["17.7733","17.3014","18.1069","17.6143",{"$nulls":4},"microtubule binding;microtubule plus-end binding","cytoplasmic microtubule;microtubule associated complex;microtubule plus-end",{"$nulls":3},4,4,4,"5.4","5.4","5.4","115.84",0,"33.94",103990000,13,"0.353205","0.683187","-0.323172","-0.947484","sp|Q9UDT6|CLIP2_HUMAN","sp|Q9UDT6|CLIP2_HUMAN",2814,"Q9UDT6","CLIP2_HUMAN","CAP-Gly domain-containing linker protein 2",null,"CLIP2"]
["14.2869","14.3031","14.4766","14.76",{"$nulls":3},"apical protein localization;cell morphogenesis;cellular pigment accumulation;epithelial cell development;neural tube closure;pattern specification process;regulation of cell shape","actin filament binding","adherens junction;apical junction complex;apical plasma membrane;cytoplasm;cytoskeleton;microtubule",{"$nulls":3},2,2,2,"1.7","1.7","1.7","216.85",0,"4.9506",29111000,11,"0.822573","0.323822","-0.323282","-2.27747","sp|Q8TF72|SHRM3_HUMAN","sp|Q8TF72|SHRM3_HUMAN",2132,"Q8TF72","SHRM3_HUMAN","Protein Shroom3",null,"SHROOM3"]
["20.4188","20.2336","20.6941","20.6056",{"$nulls":3},"response to unfolded protein;ubiquitin-dependent ERAD pathway",null,"cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;nuclear envelope",{"$nulls":3},2,2,2,"5.9","5.9","5.9","56.777",0,"6.9643",265050000,7,"1.0575","0.303888","-0.323617","-3.15254","sp|Q92575|UBXN4_HUMAN;tr|F8WB86|F8WB86_HUMAN;tr|Q6PJ80|Q6PJ80_HUMAN;tr|C9JLR4|C9JLR4_HUMAN","sp|Q92575|UBXN4_HUMAN;tr|F8WB86|F8WB86_HUMAN;tr|Q6PJ80|Q6PJ80_HUMAN;tr|C9JLR4|C9JLR4_HUMAN",2174,"Q92575","UBXN4_HUMAN","UBX domain-containing protein 4",null,"UBXN4"]
["20.9093","21.1186","21.4887","21.1873",{"$nulls":3},"interleukin-12-mediated signaling pathway;mRNA splicing, via spliceosome;RNA splicing","RNA binding;U2 snRNA binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;small nuclear ribonucleoprotein complex;spliceosomal complex;U2 snRNP","Spliceosome",null,null,6,6,6,"29.8","29.8","29.8","28.415",0,"26.641",256290000,24,"0.658829","0.390585","-0.324059","-1.7664","sp|P09661|RU2A_HUMAN;tr|H0YLR3|H0YLR3_HUMAN;tr|H0YMA0|H0YMA0_HUMAN;tr|H0YKK0|H0YKK0_HUMAN","sp|P09661|RU2A_HUMAN;tr|H0YLR3|H0YLR3_HUMAN;tr|H0YMA0|H0YMA0_HUMAN",592,"P09661","RU2A_HUMAN","U2 small nuclear ribonucleoprotein A'","2 snRNP A'","SNRPA1"]
["16.3325","15.3993","16.4996","15.8827",{"$nulls":9},1,1,1,"4.3","4.3","4.3","41.022","0.0010703","2.3892",10123000,3,"0.207827","0.815344","-0.325256","-0.581541","tr|F5H523|F5H523_HUMAN;sp|Q9P2K6|KLH42_HUMAN","tr|F5H523|F5H523_HUMAN;sp|Q9P2K6|KLH42_HUMAN",2789,"F5H523","F5H523_HUMAN",null,null,"KLHL42"]
["17.6021","17.3058","18.1017","17.4572",{"$nulls":3},"intracellular signal transduction;regulation of Rho protein signal transduction","Rho guanyl-nucleotide exchange factor activity","intracellular",{"$nulls":3},2,2,2,"5.6","5.6","5.6","50.493",0,"3.8652",53695000,3,"0.341407","0.694647","-0.325527","-0.917804","tr|E7EUY6|E7EUY6_HUMAN;tr|B1ALK7|B1ALK7_HUMAN;sp|Q14155|ARHG7_HUMAN;tr|C9JAD7|C9JAD7_HUMAN;tr|C9JDI6|C9JDI6_HUMAN;tr|B1ANY6|B1ANY6_HUMAN;tr|F6SJA5|F6SJA5_HUMAN;tr|E7ENL8|E7ENL8_HUMAN;tr|E7EU80|E7EU80_HUMAN;tr|E9PDQ5|E9PDQ5_HUMAN","tr|E7EUY6|E7EUY6_HUMAN;tr|B1ALK7|B1ALK7_HUMAN;sp|Q14155|ARHG7_HUMAN;tr|C9JAD7|C9JAD7_HUMAN;tr|C9JDI6|C9JDI6_HUMAN;tr|B1ANY6|B1ANY6_HUMAN;tr|F6SJA5|F6SJA5_HUMAN;tr|E7ENL8|E7ENL8_HUMAN;tr|E7EU80|E7EU80_HUMAN;tr|E9PDQ5|E9PDQ5_HUMAN",1604,"E7EUY6","E7EUY6_HUMAN",null,null,"ARHGEF7"]
["20.6856","20.5555","21.2636","20.629",{"$nulls":3},"cell cycle;cell proliferation;cellular response to growth factor stimulus;dTDP biosynthetic process;dTTP biosynthetic process;dUDP biosynthetic process;myoblast differentiation;nucleobase-containing small molecule interconversion;response to cadmium ion;response to estrogen","ATP binding;nucleoside phosphate kinase activity;thymidylate kinase activity;uridylate kinase activity","cytoplasm;cytosol;mitochondrial intermembrane space;mitochondrial matrix","Metabolic pathways;Pyrimidine metabolism",null,null,4,4,4,"18.4","18.4","18.4","23.819",0,"14.481",349840000,16,"0.376248","0.647304","-0.325709","-1.00564","sp|P23919|KTHY_HUMAN;tr|H7C312|H7C312_HUMAN;tr|H7BZ20|H7BZ20_HUMAN","sp|P23919|KTHY_HUMAN;tr|H7C312|H7C312_HUMAN;tr|H7BZ20|H7BZ20_HUMAN",786,"P23919","KTHY_HUMAN","Thymidylate kinase",null,"DTYMK"]
["18.7168","18.4475","18.807","19.0091",{"$nulls":4},"calcium ion binding",{"$nulls":4},2,2,2,"8.3","8.3","8.3","40.368",0,"3.4645",71457000,4,"0.715552","0.359625","-0.325889","-1.93594","tr|E9PKG6|E9PKG6_HUMAN;tr|Q2L696|Q2L696_HUMAN;tr|V9HW75|V9HW75_HUMAN;tr|A0A087WSV8|A0A087WSV8_HUMAN;sp|P80303|NUCB2_HUMAN;tr|E9PLR0|E9PLR0_HUMAN;tr|H0YEG8|H0YEG8_HUMAN;tr|E9PLE9|E9PLE9_HUMAN","tr|E9PKG6|E9PKG6_HUMAN;tr|Q2L696|Q2L696_HUMAN;tr|V9HW75|V9HW75_HUMAN;tr|A0A087WSV8|A0A087WSV8_HUMAN;sp|P80303|NUCB2_HUMAN;tr|E9PLR0|E9PLR0_HUMAN;tr|H0YEG8|H0YEG8_HUMAN;tr|E9PLE9|E9PLE9_HUMAN",1375,"E9PKG6","E9PKG6_HUMAN",null,null,"NUCB2"]
["18.2287",1,"18.8823",1,{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity;protein complex binding","mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,2,2,2,"19.8","19.8","19.8","20.105","0.00040388","3.4365",22401000,3,"0.00815739","0.984325","-0.326782","-0.0263199","sp|P51970|NDUA8_HUMAN","sp|P51970|NDUA8_HUMAN",1149,"P51970","NDUA8_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8",null,"NDUFA8"]
["20.5161","20.6779","21.4445","20.4055",{"$nulls":3},"exosomal secretion;negative regulation of apoptotic process;nucleotide-excision repair, DNA damage recognition;positive regulation of DNA binding transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;post-translational protein modification;protein deneddylation;protein deubiquitination;regulation of cell cycle;regulation of IRE1-mediated unfolded protein response;regulation of JNK cascade;transcription from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair;translation","enzyme binding;macrophage migration inhibitory factor binding;metal ion binding;metallopeptidase activity;NEDD8-specific protease activity;thiol-dependent ubiquitin-specific protease activity;transcription coactivator activity;translation initiation factor activity","cell junction;COP9 signalosome;cytoplasm;cytosol;eukaryotic translation initiation factor 3 complex;nucleoplasm;nucleus;perinuclear region of cytoplasm;synaptic vesicle",{"$nulls":3},4,4,4,"19.8","19.8","19.8","37.578",0,"23.785",317150000,10,"0.224493","0.797184","-0.328016","-0.62392","sp|Q92905|CSN5_HUMAN;tr|E5RFS1|E5RFS1_HUMAN;tr|E5RG35|E5RG35_HUMAN;tr|E5RK55|E5RK55_HUMAN;tr|E5RHF2|E5RHF2_HUMAN;tr|E5RHH5|E5RHH5_HUMAN","sp|Q92905|CSN5_HUMAN",2202,"Q92905","CSN5_HUMAN","COP9 signalosome complex subunit 5","GN5;ignalosome subunit 5","COPS5"]
["21.8628","21.4591","22.2024","21.7774",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;modulation of chemical synaptic transmission;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of programmed cell death;negative regulation of transcription, DNA-templated;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of inclusion body assembly;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;positive regulation of transcription, DNA-templated;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent ERAD pathway;Wnt signaling pathway, planar cell polarity pathway","ATP binding;ATPase activity;proteasome-activating ATPase activity;TBP-class protein binding;thyrotropin-releasing hormone receptor binding;transcription factor binding","blood microparticle;cytoplasm;cytoplasmic vesicle;cytosol;cytosolic proteasome complex;extracellular exosome;inclusion body;membrane;nuclear proteasome complex;nucleoplasm;nucleus;postsynapse;proteasome accessory complex;proteasome complex;proteasome regulatory particle, base subcomplex","Epstein-Barr virus infection;Proteasome",null,null,12,12,11,"37.7","37.7","34.7","45.626",0,"66.568",956050000,58,"0.422062","0.592941","-0.328949","-1.12225","sp|P62195|PRS8_HUMAN;tr|J3QQM1|J3QQM1_HUMAN;tr|J3QSA9|J3QSA9_HUMAN;tr|J3QLH6|J3QLH6_HUMAN;tr|J3KRP2|J3KRP2_HUMAN;tr|J3QSE0|J3QSE0_HUMAN;tr|J3QRW1|J3QRW1_HUMAN;tr|J3QRR3|J3QRR3_HUMAN","sp|P62195|PRS8_HUMAN;tr|J3QQM1|J3QQM1_HUMAN;tr|J3QSA9|J3QSA9_HUMAN;tr|J3QLH6|J3QLH6_HUMAN;tr|J3KRP2|J3KRP2_HUMAN",1291,"P62195","PRS8_HUMAN","26S proteasome regulatory subunit 8",null,"PSMC5"]
[1,"19.2177",1,"19.8761",{"$nulls":3},"apoptotic signaling pathway;cellular response to interferon-beta;cellular response to retinoic acid;extrinsic apoptotic signaling pathway;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;negative regulation of cell growth;negative regulation of intrinsic apoptotic signaling pathway;negative regulation of transcription, DNA-templated;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of peptidase activity;positive regulation of protein catabolic process;protein import into mitochondrial inner membrane;reactive oxygen species metabolic process","ATP binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity","cytoplasm;extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial respiratory chain;mitochondrial respiratory chain complex I;mitochondrion;nucleoplasm","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,2,2,2,"14.6","14.6","14.6","16.698","0.001065","2.3606",15959000,1,"0.00777516","0.983832","-0.329194","-0.0250973","sp|Q9P0J0|NDUAD_HUMAN;tr|B4DEZ3|B4DEZ3_HUMAN;tr|K7EJE1|K7EJE1_HUMAN;tr|E7ENQ6|E7ENQ6_HUMAN","sp|Q9P0J0|NDUAD_HUMAN;tr|B4DEZ3|B4DEZ3_HUMAN;tr|K7EJE1|K7EJE1_HUMAN;tr|E7ENQ6|E7ENQ6_HUMAN",2771,"Q9P0J0","NDUAD_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13",null,"NDUFA13"]
["17.5824","17.5254","18.2492","17.5172",{"$nulls":3},"cellular response to epidermal growth factor stimulus;ERBB2 signaling pathway;negative regulation of ERBB signaling pathway;negative regulation of platelet-derived growth factor receptor-beta signaling pathway;peptidyl-tyrosine dephosphorylation;protein dephosphorylation;regulation of epidermal growth factor receptor signaling pathway;tissue regeneration","non-membrane spanning protein tyrosine phosphatase activity;phosphoprotein phosphatase activity;protein tyrosine phosphatase activity;SH3 domain binding","cell projection;cytoplasm;cytosol;focal adhesion;podosome",{"$nulls":3},5,5,5,"12.2","12.2","12.2","88.105",0,"29.624",103520000,16,"0.333133","0.702413","-0.329269","-0.897018","sp|Q05209|PTN12_HUMAN;tr|H3BM04|H3BM04_HUMAN;tr|H0YC15|H0YC15_HUMAN","sp|Q05209|PTN12_HUMAN;tr|H3BM04|H3BM04_HUMAN",1452,"Q05209","PTN12_HUMAN","Tyrosine-protein phosphatase non-receptor type 12",null,"PTPN12"]
["20.9148","20.9949","21.2484","21.3199",{"$nulls":4},"RNA binding","cytosol;nucleoplasm",{"$nulls":3},2,2,2,"9.5","9.5","9.5","35.02",0,"9.2093",171760000,15,"1.59215","0.340261","-0.329295","-6.13222","tr|K7EQ02|K7EQ02_HUMAN;tr|K7EQ55|K7EQ55_HUMAN;tr|K7EK33|K7EK33_HUMAN;sp|Q96EP5|DAZP1_HUMAN","tr|K7EQ02|K7EQ02_HUMAN;tr|K7EQ55|K7EQ55_HUMAN;tr|K7EK33|K7EK33_HUMAN;sp|Q96EP5|DAZP1_HUMAN",2262,"K7EQ02","K7EQ02_HUMAN",null,null,"DAZAP1"]
["20.5424","20.8556","21.0488","21.0081",{"$nulls":5},"integral component of membrane;mitochondrial outer membrane;mitochondrion",{"$nulls":3},2,2,2,"14.3","14.3","14.3","27.835",0,"14.569",141250000,2,"0.763746","0.337318","-0.329451","-2.086","sp|Q8WY22|BRI3B_HUMAN","sp|Q8WY22|BRI3B_HUMAN",2160,"Q8WY22","BRI3B_HUMAN","BRI3-binding protein","3-binding protein","BRI3BP"]
["23.0751","22.7767","23.4821","23.0296",{"$nulls":3},"animal organ regeneration;brainstem development;cerebellum development;cerebral cortex development;'de novo' IMP biosynthetic process;dihydrofolate metabolic process;nucleobase-containing compound metabolic process;nucleoside metabolic process;purine ribonucleoside monophosphate biosynthetic process;response to inorganic substance;tetrahydrofolate biosynthetic process","cadherin binding;IMP cyclohydrolase activity;phosphoribosylaminoimidazolecarboxamide formyltransferase activity;protein homodimerization activity","cytosol;extracellular exosome;membrane;mitochondrion","Antifolate resistance;Metabolic pathways;One carbon pool by folate;Purine metabolism",null,null,23,23,23,"49.8","49.8","49.8","64.615",0,"311.26",3565700000,123,"0.458996","0.543977","-0.329981","-1.21759","sp|P31939|PUR9_HUMAN;tr|H7C1S2|H7C1S2_HUMAN;tr|C9JLK0|C9JLK0_HUMAN;tr|F8WEF0|F8WEF0_HUMAN","sp|P31939|PUR9_HUMAN",893,"P31939","PUR9_HUMAN","Bifunctional purine biosynthesis protein PURH",null,"ATIC"]
["17.3188","17.0269","17.6119","17.3945",{"$nulls":3},"amygdala development;cellular response to DNA damage stimulus;dendritic spine development;hippocampus development;learning;locomotory behavior;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process","ATP binding;FAT10 activating enzyme activity;ubiquitin activating enzyme activity","cytoplasm;cytosol","Ubiquitin mediated proteolysis",null,null,3,3,3,"3.7","3.7","3.7","117.97",0,"4.1844",91688000,6,"0.675312","0.383213","-0.3303","-1.81492","sp|A0AVT1|UBA6_HUMAN;tr|H0Y8S8|H0Y8S8_HUMAN","sp|A0AVT1|UBA6_HUMAN;tr|H0Y8S8|H0Y8S8_HUMAN",93,"A0AVT1","UBA6_HUMAN","Ubiquitin-like modifier-activating enzyme 6","biquitin-activating enzyme 6","UBA6"]
["21.9133","21.9904","22.646","21.9206",{"$nulls":3},"cellular response to hypoxia;ER to Golgi vesicle-mediated transport;IRE1-mediated unfolded protein response;negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway;negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;receptor-mediated endocytosis;response to endoplasmic reticulum stress;response to ischemia","ATP binding;chaperone binding","endocytic vesicle lumen;endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;extracellular exosome;extracellular region;focal adhesion;membrane;smooth endoplasmic reticulum","Protein processing in endoplasmic reticulum",null,null,25,25,25,"38.9","38.9","38.9","111.33",0,"323.31",2791100000,168,"0.337766","0.698702","-0.331436","-0.908655","sp|Q9Y4L1|HYOU1_HUMAN;tr|A0A087X054|A0A087X054_HUMAN;tr|E9PJ21|E9PJ21_HUMAN;tr|A0A087WWI4|A0A087WWI4_HUMAN;tr|K7EQK2|K7EQK2_HUMAN;tr|J3KTF1|J3KTF1_HUMAN;tr|J3QL06|J3QL06_HUMAN;tr|Q9BST8|Q9BST8_HUMAN;tr|J3QQH7|J3QQH7_HUMAN;tr|J3QLE9|J3QLE9_HUMAN;sp|Q9BXT5|TEX15_HUMAN","sp|Q9Y4L1|HYOU1_HUMAN;tr|A0A087X054|A0A087X054_HUMAN;tr|E9PJ21|E9PJ21_HUMAN;tr|A0A087WWI4|A0A087WWI4_HUMAN;tr|K7EQK2|K7EQK2_HUMAN",3003,"Q9Y4L1","HYOU1_HUMAN","Hypoxia up-regulated protein 1",null,"HYOU1"]
["24.0795","23.9614","24.4275","24.2768",{"$nulls":3},"cell differentiation;cytoplasmic translation;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of ubiquitin protein ligase activity;neural tube closure;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of gene expression;positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator;protein stabilization;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA 3'-UTR binding;mRNA 5'-UTR binding;protein kinase binding;RNA binding;structural constituent of ribosome;ubiquitin ligase inhibitor activity","90S preribosome;cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;intracellular ribonucleoprotein complex;membrane;microtubule organizing center;nucleolus;nucleoplasm;nucleus;protein complex;ribosome;small-subunit processome","Ribosome",null,null,9,9,9,50,50,50,"22.127",0,"110.95",1902000000,61,"1.12982","0.311497","-0.33172","-3.46458","sp|P62081|RS7_HUMAN;tr|B5MCP9|B5MCP9_HUMAN","sp|P62081|RS7_HUMAN;tr|B5MCP9|B5MCP9_HUMAN",1288,"P62081","RS7_HUMAN","40S ribosomal protein S7",null,"RPS7"]
["25.955","25.6561","26.4473","25.8286",{"$nulls":3},"retinoic acid biosynthetic process;vitamin A metabolic process","lipid binding","cytosol",{"$nulls":3},9,9,9,"82.4","82.4","82.4","10.644",0,"183.96",4289900000,53,"0.361198","0.667459","-0.332455","-0.967628","tr|A0A0A0MTB9|A0A0A0MTB9_HUMAN;tr|H0YAK8|H0YAK8_HUMAN;sp|P09455|RET1_HUMAN;tr|A0A0A0MQT0|A0A0A0MQT0_HUMAN","tr|A0A0A0MTB9|A0A0A0MTB9_HUMAN;tr|H0YAK8|H0YAK8_HUMAN;sp|P09455|RET1_HUMAN;tr|A0A0A0MQT0|A0A0A0MQT0_HUMAN",584,"A0A0A0MTB9","A0A0A0MTB9_HUMAN",null,null,"RBP1"]
["25.039","24.6893","25.7768","24.6167",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","heparin binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;intracellular ribonucleoprotein complex;nucleus","Ribosome",null,null,4,4,4,"50.8","50.8","50.8","14.787",0,"38.592",1380000000,21,"0.195127","0.826883","-0.332617","-0.549058","sp|P35268|RL22_HUMAN;tr|K7ERI7|K7ERI7_HUMAN;tr|K7EJT5|K7EJT5_HUMAN;tr|K7EP65|K7EP65_HUMAN;tr|K7EKS7|K7EKS7_HUMAN;tr|K7ELC4|K7ELC4_HUMAN;tr|K7EMH1|K7EMH1_HUMAN","sp|P35268|RL22_HUMAN;tr|K7ERI7|K7ERI7_HUMAN;tr|K7EJT5|K7EJT5_HUMAN;tr|K7EP65|K7EP65_HUMAN;tr|K7EKS7|K7EKS7_HUMAN;tr|K7ELC4|K7ELC4_HUMAN;tr|K7EMH1|K7EMH1_HUMAN",928,"P35268","RL22_HUMAN","60S ribosomal protein L22",null,"RPL22"]
["20.1012","20.0723","20.5704","20.2695",{"$nulls":5},"dynactin complex",{"$nulls":3},3,3,3,"16.6","16.6","16.6","37.433",0,"16.416",275680000,24,"0.800236","0.330103","-0.333149","-2.20364","tr|R4GMT0|R4GMT0_HUMAN;sp|P61163|ACTZ_HUMAN","tr|R4GMT0|R4GMT0_HUMAN;sp|P61163|ACTZ_HUMAN",1261,"R4GMT0","R4GMT0_HUMAN",null,null,"ACTR1A"]
["20.7893","20.8234","21.1057","21.1733",{"$nulls":3},"cellular iron ion homeostasis;iron ion transport","ferric iron binding","cell;integral component of membrane",{"$nulls":3},1,1,1,26,26,26,"5.6423",0,"8.7417",45024000,5,"1.89783","0.398173","-0.333159","-8.80566","tr|E9PQR3|E9PQR3_HUMAN;tr|E9PKM5|E9PKM5_HUMAN;tr|E9PRK8|E9PRK8_HUMAN;tr|E9PK45|E9PK45_HUMAN;tr|E9PKY7|E9PKY7_HUMAN;sp|P02794|FRIH_HUMAN","tr|E9PQR3|E9PQR3_HUMAN;tr|E9PKM5|E9PKM5_HUMAN;tr|E9PRK8|E9PRK8_HUMAN;tr|E9PK45|E9PK45_HUMAN;tr|E9PKY7|E9PKY7_HUMAN;sp|P02794|FRIH_HUMAN",484,"E9PQR3","E9PQR3_HUMAN","Ferritin {ECO:0000256|RuleBase:RU361145}",null,"FTH1"]
["23.72","23.4616","24.1563","23.6921",{"$nulls":3},"convergent extension involved in axis elongation;covalent chromatin modification;DNA methylation involved in embryo development;DNA repair;embryo implantation;embryonic placenta morphogenesis;epithelial to mesenchymal transition;innate immune response;negative regulation of DNA demethylation;negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of viral release from host cell;positive regulation of DNA binding;positive regulation of DNA repair;positive regulation of methylation-dependent chromatin silencing;positive regulation of transcription factor import into nucleus;positive regulation of transcription, DNA-templated;protein autophosphorylation;protein oligomerization;protein sumoylation;Ras protein signal transduction;regulation of genetic imprinting;transcription initiation from RNA polymerase II promoter","chromatin binding;chromo shadow domain binding;DNA binding;DNA binding transcription factor activity;Krueppel-associated box domain binding;promoter-specific chromatin binding;protein kinase activity;RNA binding;RNA polymerase II transcription coactivator activity;sequence-specific DNA binding;transcription corepressor activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity;zinc ion binding","nuclear euchromatin;nuclear heterochromatin;nucleoplasm;nucleus;RNA polymerase II transcription factor complex",{"$nulls":3},22,22,22,"45.4","45.4","45.4","88.549",0,"323.31",4266300000,201,"0.473322","0.531481","-0.333364","-1.25496","sp|Q13263|TIF1B_HUMAN;tr|M0R0K9|M0R0K9_HUMAN;tr|M0R2I3|M0R2I3_HUMAN;tr|M0R3C0|M0R3C0_HUMAN","sp|Q13263|TIF1B_HUMAN;tr|M0R0K9|M0R0K9_HUMAN",1538,"Q13263","TIF1B_HUMAN","Transcription intermediary factor 1-beta","IF1-beta","TRIM28"]
["15.951","15.7876","16.4925","15.9138",{"$nulls":3},"behavior","metal ion binding;RNA binding;tRNA (guanine-N2-)-methyltransferase activity;tRNA binding",{"$nulls":4},1,1,1,2,2,2,"81.746",0,"8.682",26172000,9,"0.417396","0.599061","-0.333818","-1.1103","sp|Q7Z2T5|TRM1L_HUMAN","sp|Q7Z2T5|TRM1L_HUMAN",1942,"Q7Z2T5","TRM1L_HUMAN","TRMT1-like protein",null,"TRMT1L"]
["21.1246","20.9124","21.8612","20.8436",{"$nulls":3},"DNA replication;DNA replication initiation;DNA unwinding involved in DNA replication;G1/S transition of mitotic cell cycle","ATP binding;DNA helicase activity;identical protein binding;single-stranded DNA binding","MCM complex;nuclear chromosome, telomeric region;nucleoplasm;nucleus","Cell cycle;DNA replication",null,null,17,17,17,"28.1","28.1","28.1","92.888",0,"127.06",1233100000,81,"0.23178","0.792982","-0.333865","-0.642379","sp|Q14566|MCM6_HUMAN","sp|Q14566|MCM6_HUMAN",1629,"Q14566","MCM6_HUMAN","DNA replication licensing factor MCM6",null,"MCM6"]
["19.0642","18.9784","19.8928","18.8177",{"$nulls":3},"peptide metabolic process;protein polyubiquitination","metal ion binding;metalloendopeptidase activity;peptide binding","cytosol;mitochondrial intermembrane space","African trypanosomiasis;Renin-angiotensin system",null,null,5,5,5,11,11,11,"78.839",0,"10.7",239390000,17,"0.222614","0.800418","-0.333909","-0.619155","sp|P52888|THOP1_HUMAN;tr|K7EP46|K7EP46_HUMAN;tr|K7EKB6|K7EKB6_HUMAN;tr|K7EIK4|K7EIK4_HUMAN;tr|K7EL32|K7EL32_HUMAN;tr|K7EL02|K7EL02_HUMAN","sp|P52888|THOP1_HUMAN;tr|K7EP46|K7EP46_HUMAN",1168,"P52888","THOP1_HUMAN","Thimet oligopeptidase",null,"THOP1"]
["18.3951","18.4243","18.8372","18.6524",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},2,2,2,"14.8","14.8","14.8","17.095","0.00038775","3.1004",40379000,4,"1.15565","0.312","-0.33505","-3.58167","tr|D6RC14|D6RC14_HUMAN;sp|P09001|RM03_HUMAN;tr|H0Y9G6|H0Y9G6_HUMAN;tr|E7ETU7|E7ETU7_HUMAN;tr|E9PF06|E9PF06_HUMAN","tr|D6RC14|D6RC14_HUMAN;sp|P09001|RM03_HUMAN;tr|H0Y9G6|H0Y9G6_HUMAN;tr|E7ETU7|E7ETU7_HUMAN;tr|E9PF06|E9PF06_HUMAN",575,"D6RC14","D6RC14_HUMAN",null,null,"MRPL3"]
["17.7895","18.1132","18.7436","17.8298",{"$nulls":3},"vacuolar transport",null,"intracellular",{"$nulls":3},1,1,1,"11.5","11.5","11.5","12.939","0.0010726","2.3924",15723000,4,"0.251356","0.771591","-0.335312","-0.691786","tr|I3L3E4|I3L3E4_HUMAN;tr|I3L4G8|I3L4G8_HUMAN;sp|Q96FZ7|CHMP6_HUMAN;tr|I3L4A1|I3L4A1_HUMAN","tr|I3L3E4|I3L3E4_HUMAN;tr|I3L4G8|I3L4G8_HUMAN;sp|Q96FZ7|CHMP6_HUMAN;tr|I3L4A1|I3L4A1_HUMAN",2272,"I3L3E4","I3L3E4_HUMAN",null,null,"CHMP6"]
["21.1103","20.974","21.6487","21.1064",{"$nulls":3},"in utero embryonic development;nucleotide-excision repair, DNA damage recognition;post-translational protein modification;protein deneddylation;response to light stimulus;signal transduction;transcription-coupled nucleotide-excision repair;ubiquitin-dependent protein catabolic process",null,"COP9 signalosome;cytoplasm;cytosol;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"20.1","20.1","20.1","47.873",0,"109.73",622830000,40,"0.452006","0.551121","-0.335365","-1.19944","sp|Q9UNS2|CSN3_HUMAN;tr|H7C3P9|H7C3P9_HUMAN;tr|C9JLV5|C9JLV5_HUMAN;tr|J3QL22|J3QL22_HUMAN;tr|J3QS85|J3QS85_HUMAN;tr|J3KTQ1|J3KTQ1_HUMAN;tr|J3QKR0|J3QKR0_HUMAN;tr|K7ES36|K7ES36_HUMAN","sp|Q9UNS2|CSN3_HUMAN;tr|H7C3P9|H7C3P9_HUMAN",2917,"Q9UNS2","CSN3_HUMAN","COP9 signalosome complex subunit 3","GN3;ignalosome subunit 3","COPS3"]
["20.607","20.4044","21.1992","20.4872",{"$nulls":3},"dephosphorylation of RNA polymerase II C-terminal domain;positive regulation of cell proliferation;positive regulation of transcription from RNA polymerase II promoter;regulation of cell cycle process;snRNA transcription from RNA polymerase II promoter","identical protein binding;RNA polymerase II core binding","centrosome;cytosol;DNA-directed RNA polymerase II, holoenzyme;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"27.3","27.3","27.3","36.899",0,"45.879",191040000,32,"0.33902","0.697815","-0.337511","-0.911805","sp|Q9NQG5|RPR1B_HUMAN;tr|A2A2M0|A2A2M0_HUMAN;tr|A0A087WUK3|A0A087WUK3_HUMAN;tr|A0A087X2D2|A0A087X2D2_HUMAN;tr|E9PIQ9|E9PIQ9_HUMAN;tr|A0A0C4DGQ6|A0A0C4DGQ6_HUMAN;sp|Q96P16|RPR1A_HUMAN","sp|Q9NQG5|RPR1B_HUMAN;tr|A2A2M0|A2A2M0_HUMAN",2669,"Q9NQG5","RPR1B_HUMAN","Regulation of nuclear pre-mRNA domain-containing protein 1B",null,"RPRD1B"]
["17.1441","18.2199","18.243","17.7961",{"$nulls":3},"regulation of actin cytoskeleton organization;regulation of actin filament polymerization;regulation of cell motility;regulation of cell shape;regulation of small GTPase mediated signal transduction;small GTPase mediated signal transduction","cadherin binding;GTPase activator activity","cytoplasm;cytosol;nuclear speck;plasma membrane",{"$nulls":3},3,3,3,"6.3","6.3","6.3","74.976",0,"5.6221",106840000,3,"0.207037","0.816143","-0.337544","-0.579524","sp|Q8N392|RHG18_HUMAN","sp|Q8N392|RHG18_HUMAN",2044,"Q8N392","RHG18_HUMAN","Rho GTPase-activating protein 18",null,"ARHGAP18"]
["22.4151","22.5213","22.9617","22.6501",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to organic cyclic compound;response to organonitrogen compound;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;membrane;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex","Proteasome",null,null,5,5,5,"31.3","31.3","31.3","22.836",0,"68.668",677250000,26,"0.752956","0.339318","-0.337684","-2.05189","sp|P49721|PSB2_HUMAN;tr|A0A087WVV1|A0A087WVV1_HUMAN","sp|P49721|PSB2_HUMAN",1087,"P49721","PSB2_HUMAN","Proteasome subunit beta type-2",null,"PSMB2"]
["16.8588","17.0116","17.1066","17.4396",{"$nulls":3},"beta-catenin-TCF complex assembly;cell cycle;cellular response to lipopolysaccharide;endodermal cell fate commitment;histone H2B ubiquitination;histone monoubiquitination;mRNA polyadenylation;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of epithelial cell proliferation;negative regulation of fibroblast proliferation;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of myeloid cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell cycle G1/S phase transition;positive regulation of mRNA 3'-end processing;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;positive regulation of Wnt signaling pathway;protein destabilization;protein ubiquitination;recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex;regulation of cell growth;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;Wnt signaling pathway","RNA polymerase II core binding;transcription factor activity, RNA polymerase II transcription factor binding","Cdc73/Paf1 complex;cytosol;nuclear chromosome, telomeric region;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"4.1","4.1","4.1","60.576",0,"9.2646",46002000,8,"0.685201","0.377017","-0.337877","-1.84432","sp|Q6P1J9|CDC73_HUMAN","sp|Q6P1J9|CDC73_HUMAN",1881,"Q6P1J9","CDC73_HUMAN","Parafibromin",null,"CDC73"]
["18.1301","17.7285","18.5899","17.9467",{"$nulls":3},"actomyosin structure organization;cortical actin cytoskeleton organization","actin binding;cadherin binding;structural constituent of cytoskeleton","cytoskeleton;cytosol;plasma membrane",{"$nulls":3},7,7,7,"14.5","14.5","14.5","98.502",0,"16.969",119030000,16,"0.331972","0.703277","-0.339017","-0.894104","sp|Q9H4G0|E41L1_HUMAN;tr|A0A0C4DH22|A0A0C4DH22_HUMAN;tr|A0A0D9SG07|A0A0D9SG07_HUMAN;tr|X6RC15|X6RC15_HUMAN;tr|H7C2K6|H7C2K6_HUMAN;tr|Q4VXN7|Q4VXN7_HUMAN;tr|Q4VXN6|Q4VXN6_HUMAN;tr|Q4VXN5|Q4VXN5_HUMAN;tr|Q4VXN2|Q4VXN2_HUMAN;tr|Q4VXN8|Q4VXN8_HUMAN;tr|H0Y482|H0Y482_HUMAN;tr|Q4VXN1|Q4VXN1_HUMAN;tr|Q4VXN0|Q4VXN0_HUMAN","sp|Q9H4G0|E41L1_HUMAN;tr|A0A0C4DH22|A0A0C4DH22_HUMAN;tr|A0A0D9SG07|A0A0D9SG07_HUMAN;tr|X6RC15|X6RC15_HUMAN",2597,"Q9H4G0","E41L1_HUMAN","Band 4.1-like protein 1",null,"EPB41L1"]
["19.1677","19.3704","19.6092","19.6086",{"$nulls":3},"axon extension;B cell differentiation;basement membrane organization;calcium-independent cell-matrix adhesion;cardiac muscle cell differentiation;cell adhesion mediated by integrin;cell fate specification;cell migration;cell migration involved in sprouting angiogenesis;cell-cell adhesion mediated by integrin;cell-matrix adhesion;cell-substrate adhesion;cellular defense response;cellular response to low-density lipoprotein particle stimulus;dendrite morphogenesis;extracellular matrix organization;formation of radial glial scaffolds;G1/S transition of mitotic cell cycle;germ cell migration;heterotypic cell-cell adhesion;homophilic cell adhesion via plasma membrane adhesion molecules;in utero embryonic development;integrin-mediated signaling pathway;leukocyte cell-cell adhesion;leukocyte migration;leukocyte tethering or rolling;mesodermal cell differentiation;negative regulation of anoikis;negative regulation of cell differentiation;negative regulation of Rho protein signal transduction;positive regulation of angiogenesis;positive regulation of apoptotic process;positive regulation of cell proliferation;positive regulation of GTPase activity;positive regulation of protein kinase B signaling;positive regulation of protein localization to plasma membrane;positive regulation of receptor activity;receptor internalization;regulation of cell cycle;regulation of collagen catabolic process;regulation of immune response;sarcomere organization;visual learning","actin binding;cadherin binding;cell adhesion molecule binding;collagen binding involved in cell-matrix adhesion;coreceptor activity;fibronectin binding;integrin binding;laminin binding;metal ion binding;protease binding;protein complex binding;protein heterodimerization activity;virus receptor activity","cell surface;cleavage furrow;cytoplasm;dendritic spine;external side of plasma membrane;extracellular exosome;filopodium;focal adhesion;integrin alpha10-beta1 complex;integrin alpha11-beta1 complex;integrin alpha1-beta1 complex;integrin alpha2-beta1 complex;integrin alpha3-beta1 complex;integrin alpha7-beta1 complex;integrin alpha8-beta1 complex;integrin complex;intercalated disc;invadopodium membrane;lamellipodium;melanosome;membrane;membrane raft;myelin sheath abaxonal region;neuromuscular junction;perinuclear region of cytoplasm;plasma membrane;receptor complex;recycling endosome;ruffle;ruffle membrane;sarcolemma;synaptic membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Axon guidance;Bacterial invasion of epithelial cells;Cell adhesion molecules (CAMs);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);Leishmaniasis;Leukocyte transendothelial migration;Pathogenic Escherichia coli infection;Pathways in cancer;Pertussis;Phagosome;PI3K-Akt signaling pathway;Platelet activation;Proteoglycans in cancer;Rap1 signaling pathway;Regulation of actin cytoskeleton;Shigellosis;Small cell lung cancer;Tight junction;Toxoplasmosis;Yersinia infection",null,null,6,6,6,8,8,8,"88.414",0,"9.0388",284430000,16,"1.10459","0.307607","-0.339808","-3.35315","sp|P05556|ITB1_HUMAN;tr|C9JPK5|C9JPK5_HUMAN;tr|H7C4N8|H7C4N8_HUMAN;tr|Q5T3E6|Q5T3E6_HUMAN;tr|E9PLR6|E9PLR6_HUMAN;tr|E7EUI6|E7EUI6_HUMAN;tr|E7EQW5|E7EQW5_HUMAN","sp|P05556|ITB1_HUMAN",523,"P05556","ITB1_HUMAN","Integrin beta-1",null,"ITGB1"]
["21.0525","20.862","21.3941","21.2003",{"$nulls":3},"actin filament polymerization;Arp2/3 complex-mediated actin nucleation;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component;positive regulation of lamellipodium assembly;positive regulation of substrate adhesion-dependent cell spreading","actin binding;structural constituent of cytoskeleton","actin cytoskeleton;Arp2/3 protein complex;cell leading edge;cytosol;endosome;extracellular exosome;focal adhesion;muscle cell projection membrane;neuron projection;synapse","Bacterial invasion of epithelial cells;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,8,8,8,"41.3","41.3","41.3","34.333",0,"11.755",479400000,12,"0.887895","0.298972","-0.339918","-2.50191","sp|O15144|ARPC2_HUMAN;tr|C9JTV5|C9JTV5_HUMAN;tr|G5E9J0|G5E9J0_HUMAN;tr|G5E9S7|G5E9S7_HUMAN;tr|H7C3F9|H7C3F9_HUMAN","sp|O15144|ARPC2_HUMAN",201,"O15144","ARPC2_HUMAN","Actin-related protein 2/3 complex subunit 2",null,"ARPC2"]
["17.2704","17.1324","17.8052","17.2793",{"$nulls":3},"tRNA modification",{"$nulls":5},2,2,2,"10.6","10.6","10.6","39.028",0,"12.759",36567000,8,"0.472892","0.531893","-0.340879","-1.25384","sp|Q5T6V5|CI064_HUMAN","sp|Q5T6V5|CI064_HUMAN",1836,"Q5T6V5","QSPP_HUMAN","Queuosine salvage protein {ECO:0000303|PubMed:24911101}",null,"C9orf64"]
["19.7189","20.4999","20.3134","20.5876",{"$nulls":3},"anterograde axonal transport;positive regulation of dendrite morphogenesis;positive regulation of early endosome to late endosome transport;positive regulation of receptor-mediated endocytosis;protein transport;regulation of axon extension;regulation of exocytosis","GDP binding;GTP binding;GTPase activity","axon cytoplasm;cleavage furrow;cytoplasmic side of early endosome membrane;cytoplasmic side of plasma membrane;cytoplasmic vesicle membrane;cytosol;early endosome membrane;endoplasmic reticulum membrane;endosome;extracellular exosome;focal adhesion;Golgi cisterna membrane;trans-Golgi network;vesicle membrane",{"$nulls":3},3,3,3,"19.6","19.6","19.6","24.347",0,"87.757",145300000,14,"0.304085","0.723506","-0.341069","-0.824156","sp|Q9UL25|RAB21_HUMAN","sp|Q9UL25|RAB21_HUMAN",2883,"Q9UL25","RAB21_HUMAN","Ras-related protein Rab-21",null,"RAB21"]
["17.5353",1,"18.2177",1,{"$nulls":3},"neutrophil degranulation;post-Golgi vesicle-mediated transport;protein transport",null,"clathrin-coated vesicle;integral component of membrane;plasma membrane;recycling endosome membrane;specific granule membrane;synaptic vesicle membrane;trans-Golgi network;zymogen granule membrane",{"$nulls":3},2,2,2,"6.5","6.5","6.5","37.92","0.00039002","3.1528",15406000,7,"0.00886667","0.984112","-0.341202","-0.0285861","sp|O15126|SCAM1_HUMAN;tr|A0A087WTX8|A0A087WTX8_HUMAN;tr|A0A087WZA6|A0A087WZA6_HUMAN;tr|A0A087WXB0|A0A087WXB0_HUMAN","sp|O15126|SCAM1_HUMAN;tr|A0A087WTX8|A0A087WTX8_HUMAN;tr|A0A087WZA6|A0A087WZA6_HUMAN;tr|A0A087WXB0|A0A087WXB0_HUMAN",198,"O15126","SCAM1_HUMAN","Secretory carrier-associated membrane protein 1","ecretory carrier membrane protein 1","SCAMP1"]
["17.5229","17.0915","18.081","17.2163",{"$nulls":9},2,2,2,"5.2","5.2","5.2","64.705",0,"5.3909",65865000,10,"0.257273","0.767836","-0.341475","-0.706681","tr|A0A087WWS7|A0A087WWS7_HUMAN;sp|Q15833|STXB2_HUMAN;tr|M0R1A1|M0R1A1_HUMAN;tr|M0R0M7|M0R0M7_HUMAN","tr|A0A087WWS7|A0A087WWS7_HUMAN;sp|Q15833|STXB2_HUMAN;tr|M0R1A1|M0R1A1_HUMAN;tr|M0R0M7|M0R0M7_HUMAN",1726,"A0A087WWS7"]
["18.8472","18.7392","19.3775","18.895",{"$nulls":4},"ubiquitin-protein transferase activity",{"$nulls":4},5,5,5,"9.4","9.4","9.4","88.082",0,"170.94",168120000,28,"0.523451","0.502884","-0.343026","-1.38774","tr|A0A0D9SG77|A0A0D9SG77_HUMAN;sp|Q05086|UBE3A_HUMAN;tr|A0A0D9SGI3|A0A0D9SGI3_HUMAN;tr|A0A0D9SG63|A0A0D9SG63_HUMAN;tr|S4R306|S4R306_HUMAN","tr|A0A0D9SG77|A0A0D9SG77_HUMAN;sp|Q05086|UBE3A_HUMAN",1451,"A0A0D9SG77","A0A0D9SG77_HUMAN",null,null,"UBE3A"]
["18.7987","18.8326","19.4164","18.9015",{"$nulls":3},"response to retinoic acid","hydrolase activity","cytoplasm;nucleus",{"$nulls":3},2,2,2,22,22,22,"24.418",0,"4.2292",49061000,7,"0.501947","0.513619","-0.343252","-1.33037","sp|Q8WZ82|OVCA2_HUMAN","sp|Q8WZ82|OVCA2_HUMAN",2162,"Q8WZ82","OVCA2_HUMAN","Esterase OVCA2",null,"OVCA2"]
["19.8595","19.514","20.3669","19.6938",{"$nulls":3},"cell proliferation;circadian regulation of gene expression;DNA-templated transcription, termination;endothelial cell activation;Golgi ribbon formation;histone H4-R3 methylation;liver regeneration;negative regulation of cell differentiation;peptidyl-arginine methylation;peptidyl-arginine N-methylation;positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway;positive regulation of oligodendrocyte differentiation;regulation of DNA methylation;regulation of ERK1 and ERK2 cascade;regulation of mitotic nuclear division;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;spliceosomal snRNP assembly","core promoter sequence-specific DNA binding;histone methyltransferase activity (H4-R3 specific);histone-arginine N-methyltransferase activity;identical protein binding;methyl-CpG binding;methyltransferase activity;protein complex binding;protein heterodimerization activity;protein-arginine N-methyltransferase activity;protein-arginine omega-N symmetric methyltransferase activity;ribonucleoprotein complex binding;transcription corepressor activity","cytoplasm;cytosol;Golgi apparatus;histone methyltransferase complex;methylosome;nucleoplasm;nucleus;protein complex","RNA transport",null,null,6,6,6,"16.5","16.5","16.5","72.683",0,"30.59",306640000,23,"0.337586","0.697843","-0.343587","-0.908202","sp|O14744|ANM5_HUMAN;tr|H0YJX6|H0YJX6_HUMAN;tr|H0YJ77|H0YJ77_HUMAN;tr|G3V5T6|G3V5T6_HUMAN;tr|G3V5L5|G3V5L5_HUMAN;tr|G3V580|G3V580_HUMAN;tr|G3V2L6|G3V2L6_HUMAN;tr|H0YJD3|H0YJD3_HUMAN;tr|G3V2X6|G3V2X6_HUMAN;tr|C9JSX3|C9JSX3_HUMAN","sp|O14744|ANM5_HUMAN;tr|H0YJX6|H0YJX6_HUMAN;tr|H0YJ77|H0YJ77_HUMAN",169,"O14744","ANM5_HUMAN","Protein arginine N-methyltransferase 5",null,"PRMT5"]
["21.6027","21.5703","21.9992","21.8622",{"$nulls":3},"cell adhesion","cadherin binding","cytosol;focal adhesion;plasma membrane",{"$nulls":3},22,22,22,"29.4","29.4","29.4","114.02",0,"249.74",2296700000,116,"1.40472","0.331224","-0.344177","-4.88908","sp|Q86W92|LIPB1_HUMAN;tr|F5GZP6|F5GZP6_HUMAN;tr|H0YFE4|H0YFE4_HUMAN;tr|A0A0A0MTP2|A0A0A0MTP2_HUMAN;tr|H0YGH8|H0YGH8_HUMAN;tr|F5H6Q7|F5H6Q7_HUMAN;tr|F5H0E0|F5H0E0_HUMAN;tr|F5H495|F5H495_HUMAN;tr|E9PP16|E9PP16_HUMAN;sp|Q8ND30|LIPB2_HUMAN","sp|Q86W92|LIPB1_HUMAN;tr|F5GZP6|F5GZP6_HUMAN",1991,"Q86W92","LIPB1_HUMAN","Liprin-beta-1",null,"PPFIBP1"]
["17.8364","18.0763","18.3967","18.2051",{"$nulls":9},1,1,1,3,3,3,"30.178","0.0097245","1.669",43948000,4,"0.812761","0.323141","-0.344576","-2.24486","tr|J3QL56|J3QL56_HUMAN;sp|O75880|SCO1_HUMAN","tr|J3QL56|J3QL56_HUMAN;sp|O75880|SCO1_HUMAN",373,"J3QL56","J3QL56_HUMAN",null,null,"SCO1"]
["21.3187","21.2568","21.799","21.4662",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"6.5","6.5","6.5","17.806",0,"11.106",128400000,5,"0.748312","0.340553","-0.344857","-2.0373","tr|H0Y8N0|H0Y8N0_HUMAN;tr|D6RAA6|D6RAA6_HUMAN;sp|P57088|TMM33_HUMAN","tr|H0Y8N0|H0Y8N0_HUMAN;tr|D6RAA6|D6RAA6_HUMAN;sp|P57088|TMM33_HUMAN",1227,"H0Y8N0","H0Y8N0_HUMAN",null,null,"TMEM33"]
["17.5076","17.2436","18.1913","17.2501",{"$nulls":5},"cytosol",{"$nulls":3},4,4,4,"5.9","5.9","5.9","107.21",0,"12.788",92041000,14,"0.257034","0.767351","-0.345122","-0.706079","tr|Q5JR04|Q5JR04_HUMAN;sp|Q9HCE1|MOV10_HUMAN","tr|Q5JR04|Q5JR04_HUMAN;sp|Q9HCE1|MOV10_HUMAN",2643,"Q5JR04","Q5JR04_HUMAN"]
["21.3653","21.3038","21.9908","21.3687",{"$nulls":4},"glutathione transferase activity;protein disulfide oxidoreductase activity",{"$nulls":4},3,3,3,"22.1","22.1","22.1","21.707",0,"25.849",321810000,13,"0.415168","0.600907","-0.345228","-1.1046","tr|E9PFN5|E9PFN5_HUMAN;sp|Q9Y2Q3|GSTK1_HUMAN;tr|C9JNT3|C9JNT3_HUMAN","tr|E9PFN5|E9PFN5_HUMAN;sp|Q9Y2Q3|GSTK1_HUMAN",2953,"E9PFN5","E9PFN5_HUMAN","Glutathione S-transferase kappa {ECO:0000256|PIRNR:PIRNR006386}",null,"GSTK1"]
["24.1648","23.4817","24.6029","23.7348",{"$nulls":3},"erythrocyte differentiation;interleukin-12-mediated signaling pathway;iron-sulfur cluster assembly;negative regulation of apoptotic process;negative regulation of erythrocyte differentiation;negative regulation of hematopoietic stem cell differentiation;protein export from nucleus;protein folding;regulation of erythrocyte differentiation","ATP binding;RNA binding;ubiquitin protein ligase binding;unfolded protein binding","cytoplasm;extracellular exosome;extracellular matrix;focal adhesion;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;myelin sheath;nucleolus","RNA degradation;Tuberculosis",null,null,23,23,23,"42.3","42.3","42.3","73.68",0,"290.71",5602900000,193,"0.225206","0.796253","-0.34558","-0.625728","sp|P38646|GRP75_HUMAN;tr|D6RJI2|D6RJI2_HUMAN;tr|H0YBG6|H0YBG6_HUMAN;tr|D6RA73|D6RA73_HUMAN;tr|H0Y8S0|H0Y8S0_HUMAN","sp|P38646|GRP75_HUMAN",959,"P38646","GRP75_HUMAN","Stress-70 protein, mitochondrial",null,"HSPA9"]
["20.4454","20.0655","20.8827","20.3197",{"$nulls":4},"NAD binding;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor",{"$nulls":4},2,2,2,"8.6","8.6","8.6","20.275",0,"5.0163",145960000,1,"0.381215","0.640705","-0.345761","-1.01821","tr|D6RAX2|D6RAX2_HUMAN;sp|Q13363|CTBP1_HUMAN;tr|A0A087WYL1|A0A087WYL1_HUMAN;tr|H0Y9M9|H0Y9M9_HUMAN;tr|E7ESU7|E7ESU7_HUMAN;tr|E7EPF8|E7EPF8_HUMAN;tr|H0Y8W7|H0Y8W7_HUMAN;sp|P56545|CTBP2_HUMAN;tr|Q5SQP8|Q5SQP8_HUMAN","tr|D6RAX2|D6RAX2_HUMAN;sp|Q13363|CTBP1_HUMAN;tr|A0A087WYL1|A0A087WYL1_HUMAN;tr|H0Y9M9|H0Y9M9_HUMAN;tr|E7ESU7|E7ESU7_HUMAN;tr|E7EPF8|E7EPF8_HUMAN;tr|H0Y8W7|H0Y8W7_HUMAN;sp|P56545|CTBP2_HUMAN;tr|Q5SQP8|Q5SQP8_HUMAN",1546,"D6RAX2","D6RAX2_HUMAN",null,null,"CTBP1"]
["21.2604","20.3967","21.6376","20.7111",{"$nulls":3},"activation of MAPK activity;intracellular protein transport;negative regulation of gene expression;negative regulation of protein secretion;positive regulation of gene expression;positive regulation of protein phosphorylation;protein folding;protein secretion;protein unfolding;regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway","chaperone binding;protein homodimerization activity","cell surface;endoplasmic reticulum;endoplasmic reticulum lumen;extracellular exosome;melanosome;membrane;smooth endoplasmic reticulum;transport vesicle","Protein processing in endoplasmic reticulum",null,null,4,4,4,"19.9","19.9","19.9","28.993",0,"9.7204",350050000,10,"0.193954","0.828876","-0.345827","-0.546049","sp|P30040|ERP29_HUMAN;tr|F8VY02|F8VY02_HUMAN;tr|F8W1G0|F8W1G0_HUMAN","sp|P30040|ERP29_HUMAN;tr|F8VY02|F8VY02_HUMAN",854,"P30040","ERP29_HUMAN","Endoplasmic reticulum resident protein 29","Rp29","ERP29"]
["17.8358","20.3946","18.3539","20.5707",{"$nulls":3},"ATP biosynthetic process;ATP hydrolysis coupled cation transmembrane transport;ATP synthesis coupled proton transport;cristae formation;mitochondrial ATP synthesis coupled proton transport","hydrogen ion transmembrane transporter activity;transmembrane transporter activity","cytosol;extracellular exosome;mitochondrial inner membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase, stator stalk;mitochondrion;myelin sheath;nucleoplasm","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,2,2,2,"16.8","16.8","16.8","18.491",0,"5.7232",87239000,8,"0.0672791","0.936197","-0.347148","-0.20508","sp|O75947|ATP5H_HUMAN;tr|F5H608|F5H608_HUMAN","sp|O75947|ATP5H_HUMAN;tr|F5H608|F5H608_HUMAN",379,"O75947","ATP5H_HUMAN","ATP synthase subunit d, mitochondrial","TPase subunit d","ATP5H"]
["22.6782","22.488","23.3411","22.5208",{"$nulls":5},"extracellular exosome;integral component of membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrion",{"$nulls":3},1,1,1,"25.9","25.9","25.9","6.4575",0,"45.499",206290000,10,"0.304874","0.724633","-0.347828","-0.826133","sp|Q96IX5|USMG5_HUMAN","sp|Q96IX5|USMG5_HUMAN",2300,"Q96IX5","USMG5_HUMAN","Up-regulated during skeletal muscle growth protein 5",null,"USMG5"]
["15.8855",1,1,"16.582",{"$nulls":3},"antigen processing and presentation;peptidyl-cysteine methylation;positive regulation of dopamine uptake involved in synaptic transmission;protein transport;regulation of exocytosis;regulation of vesicle size","GDP binding;GTP binding;GTPase activity;GTP-dependent protein binding;myosin V binding","anchored component of synaptic vesicle membrane;cytoplasm;cytosol;extracellular exosome;perinuclear region of cytoplasm;plasma membrane;secretory granule;vesicle",{"$nulls":3},1,1,1,"7.3","7.3","7.3","24.758","0.0091533","1.7112",10758000,3,"0.010038","0.983441","-0.348247","-0.0323209","sp|P20337|RAB3B_HUMAN","sp|P20337|RAB3B_HUMAN",740,"P20337","RAB3B_HUMAN","Ras-related protein Rab-3B",null,"RAB3B"]
["19.8976","19.7092","20.2897","20.0148",{"$nulls":4},"hydrolase activity",{"$nulls":4},2,2,2,"12.7","12.7","12.7","17.981","0.001124","2.7982",99375000,5,"0.766169","0.338026","-0.348875","-2.0937","tr|A0A087X1K9|A0A087X1K9_HUMAN;tr|E5RGR0|E5RGR0_HUMAN;sp|O75608|LYPA1_HUMAN;tr|E5RJ48|E5RJ48_HUMAN;tr|E5RI35|E5RI35_HUMAN;tr|B4DP64|B4DP64_HUMAN","tr|A0A087X1K9|A0A087X1K9_HUMAN;tr|E5RGR0|E5RGR0_HUMAN;sp|O75608|LYPA1_HUMAN;tr|E5RJ48|E5RJ48_HUMAN;tr|E5RI35|E5RI35_HUMAN;tr|B4DP64|B4DP64_HUMAN",355,"A0A087X1K9","A0A087X1K9_HUMAN",null,null,"LYPLA1"]
["17.2546","16.8324","17.8944","16.8908",{"$nulls":3},"endoplasmic reticulum organization;endoplasmic reticulum tubular network membrane organization;Golgi organization;protein homooligomerization","GTP binding;GTPase activity;identical protein binding","endoplasmic reticulum;endoplasmic reticulum tubular network membrane;integral component of membrane;membrane",{"$nulls":3},3,3,3,"9.1","9.1","9.1","66.228",0,"26.472",47817000,16,"0.231343","0.79217","-0.349089","-0.641273","sp|Q8NHH9|ATLA2_HUMAN;tr|B5MCN0|B5MCN0_HUMAN;tr|C9JQQ5|C9JQQ5_HUMAN;tr|C9JC25|C9JC25_HUMAN","sp|Q8NHH9|ATLA2_HUMAN;tr|B5MCN0|B5MCN0_HUMAN",2101,"Q8NHH9","ATLA2_HUMAN","Atlastin-2",null,"ATL2"]
["20.3215","19.9792","20.7651","20.2342",{"$nulls":3},"cellular protein metabolic process;microtubule-based movement;post-translational protein modification","cadherin binding;kinesin binding;RNA binding","endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;integral component of membrane;integral component of plasma membrane;membrane",{"$nulls":3},21,21,21,"20.5","20.5","20.5","156.27",0,"108.59",1146700000,89,"0.415719","0.59964","-0.349281","-1.10601","sp|Q86UP2|KTN1_HUMAN;tr|G3V4Y7|G3V4Y7_HUMAN;tr|B7Z6P3|B7Z6P3_HUMAN;tr|G3V5P0|G3V5P0_HUMAN;tr|H0YJZ8|H0YJZ8_HUMAN;tr|G3V5G2|G3V5G2_HUMAN;tr|H0YJP2|H0YJP2_HUMAN;tr|H0YJV5|H0YJV5_HUMAN","sp|Q86UP2|KTN1_HUMAN;tr|G3V4Y7|G3V4Y7_HUMAN",1979,"Q86UP2","KTN1_HUMAN","Kinectin",null,"KTN1"]
["17.701","16.8272","18.8152","16.4117",{"$nulls":3},"cholesterol biosynthetic process;fatty acid metabolic process;steroid metabolic process;sterol biosynthetic process","C-4 methylsterol oxidase activity;iron ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;plasma membrane","Metabolic pathways;Steroid biosynthesis",null,null,1,1,1,"4.8","4.8","4.8","35.215","0.00075586","2.8676",36872000,4,"0.091335","0.920961","-0.349311","-0.273184","sp|Q15800|MSMO1_HUMAN","sp|Q15800|MSMO1_HUMAN",1723,"Q15800","MSMO1_HUMAN","Methylsterol monooxygenase 1",null,"MSMO1"]
["18.4845","18.4712","19.2994","18.3551",{"$nulls":3},"DNA methylation;negative regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding transcription factor activity;protein binding, bridging;sequence-specific DNA binding;zinc ion binding","nuclear speck;nucleoplasm;nucleus;NuRD complex",{"$nulls":3},3,3,2,"5.5","5.5","3.8","68.062",0,"44.005",204060000,10,"0.27055","0.756916","-0.349446","-0.740049","sp|Q86YP4|P66A_HUMAN","sp|Q86YP4|P66A_HUMAN",2002,"Q86YP4","P66A_HUMAN","Transcriptional repressor p66-alpha","p66alpha","GATAD2A"]
["19.1886","19.2843","19.7459","19.4278",{"$nulls":3},"cell-cell adhesion","cadherin binding","plasma membrane",{"$nulls":3},11,11,11,"19.7","19.7","19.7","104.85",0,"47.256",409170000,41,"0.771231","0.337619","-0.350415","-2.10983","tr|C9JZR2|C9JZR2_HUMAN;sp|O60716|CTND1_HUMAN;tr|E9PRE2|E9PRE2_HUMAN;tr|H0YC95|H0YC95_HUMAN;tr|E9PKL1|E9PKL1_HUMAN","tr|C9JZR2|C9JZR2_HUMAN;sp|O60716|CTND1_HUMAN",301,"C9JZR2","C9JZR2_HUMAN",null,null,"CTNND1"]
["23.3058","23.1689","23.9343","23.2414",{"$nulls":3},"blood coagulation;negative regulation of apoptotic process;negative regulation of coagulation;platelet degranulation;response to organic substance;signal transduction","calcium ion binding;calcium-dependent phospholipid binding;phospholipase inhibitor activity;phospholipid binding","cytoplasm;cytosol;endothelial microparticle;external side of plasma membrane;extracellular exosome;extracellular region;focal adhesion;intracellular;membrane",{"$nulls":3},12,12,12,"48.8","48.8","48.8","35.936",0,"238.26",2308200000,78,"0.371073","0.654773","-0.350513","-0.992554","sp|P08758|ANXA5_HUMAN;tr|D6RBL5|D6RBL5_HUMAN;tr|E9PHT9|E9PHT9_HUMAN;tr|D6RBE9|D6RBE9_HUMAN;tr|D6RCN3|D6RCN3_HUMAN","sp|P08758|ANXA5_HUMAN;tr|D6RBL5|D6RBL5_HUMAN;tr|E9PHT9|E9PHT9_HUMAN;tr|D6RBE9|D6RBE9_HUMAN",572,"P08758","ANXA5_HUMAN","Annexin A5",null,"ANXA5"]
["18.434","18.1866","19.0025","18.3194",{"$nulls":9},4,4,4,"22.2","22.2","22.2","33.201",0,"6.0166",70304000,9,"0.360238","0.668356","-0.350604","-0.965206","tr|V9GYX7|V9GYX7_HUMAN;sp|Q9NZ32|ARP10_HUMAN;tr|G3V2Q5|G3V2Q5_HUMAN;tr|G3V5Y4|G3V5Y4_HUMAN;tr|F6S9Y6|F6S9Y6_HUMAN","tr|V9GYX7|V9GYX7_HUMAN;sp|Q9NZ32|ARP10_HUMAN;tr|G3V2Q5|G3V2Q5_HUMAN;tr|G3V5Y4|G3V5Y4_HUMAN;tr|F6S9Y6|F6S9Y6_HUMAN",2755,"V9GYX7","V9GYX7_HUMAN",null,null,"ACTR10"]
["23.2554","22.7337","23.2272","23.4636",{"$nulls":3},"bone development;chaperone-mediated protein folding;positive regulation by host of viral genome replication;positive regulation by host of viral process;positive regulation of multicellular organism growth;protein peptidyl-prolyl isomerization;protein stabilization","peptidyl-prolyl cis-trans isomerase activity;protein complex binding;RNA binding;RNA polymerase binding;unfolded protein binding","endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;extracellular exosome;focal adhesion;macromolecular complex;melanosome;membrane;nucleus;perinuclear region of cytoplasm;smooth endoplasmic reticulum",{"$nulls":3},8,8,8,"41.7","41.7","41.7","23.742",0,"18.475",1110900000,36,"0.461987","0.541536","-0.350917","-1.22538","sp|P23284|PPIB_HUMAN","sp|P23284|PPIB_HUMAN",775,"P23284","PPIB_HUMAN","Peptidyl-prolyl cis-trans isomerase B","PIase B","PPIB"]
["16.6115","16.4573","17.2118","16.5591",{"$nulls":3},"cargo loading into vesicle;ER to Golgi vesicle-mediated transport;protein exit from endoplasmic reticulum;protein localization to endoplasmic reticulum exit site","enzyme activator activity","endoplasmic reticulum exit site;endoplasmic reticulum membrane;integral component of membrane;membrane",{"$nulls":3},2,2,2,"3.5","3.5","3.5","90.995",0,"15.335",39196000,12,"0.392445","0.62706","-0.351014","-1.04669","sp|O15320|CTGE5_HUMAN;tr|G3V599|G3V599_HUMAN;sp|Q96RT6|CTGE2_HUMAN","sp|O15320|CTGE5_HUMAN;tr|G3V599|G3V599_HUMAN;sp|Q96RT6|CTGE2_HUMAN",213,"O15320","CTGE5_HUMAN","Endoplasmic reticulum export factor CTAGE5 {ECO:0000305}",null,"CTAGE5"]
["21.6723","21.9656","22.1767","22.1635",{"$nulls":3},"aging;cellular amino acid metabolic process;glutathione biosynthetic process;nervous system development;response to amino acid;response to cadmium ion;response to nutrient levels;response to oxidative stress;response to tumor necrosis factor;response to xenobiotic stimulus","ATP binding;glutathione binding;glutathione synthase activity;glycine binding;identical protein binding;magnesium ion binding;protein homodimerization activity","cytosol;extracellular exosome","Cysteine and methionine metabolism;Ferroptosis;Glutathione metabolism;Metabolic pathways",null,null,13,13,13,"30.8","30.8","30.8","52.384",0,"65.237",1005700000,51,"0.856304","0.304251","-0.351136","-2.39173","sp|P48637|GSHB_HUMAN","sp|P48637|GSHB_HUMAN",1057,"P48637","GSHB_HUMAN","Glutathione synthetase","SH synthetase;SH-S","GSS"]
["16.3736","16.4311","17.6499","15.8573",{"$nulls":3},"positive regulation of protein binding;positive regulation of protein localization to nucleolus;positive regulation of RNA biosynthetic process;ribosomal large subunit export from nucleus","protein binding, bridging;ribosomal large subunit binding;RNA binding","cytoplasm;membrane;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes;RNA transport",null,null,1,1,1,"3.4","3.4","3.4","57.603","0.00039809","3.3374",26410000,9,"0.134829","0.894989","-0.351213","-0.39164","sp|Q96D46|NMD3_HUMAN;tr|C9JA08|C9JA08_HUMAN","sp|Q96D46|NMD3_HUMAN;tr|C9JA08|C9JA08_HUMAN",2254,"Q96D46","NMD3_HUMAN","60S ribosomal export protein NMD3","NMD3","NMD3"]
["21.3788","21.3556","21.8326","21.6045",{"$nulls":3},"proteolysis","aminopeptidase activity;manganese ion binding;metalloexopeptidase activity","cytosol;extracellular exosome;focal adhesion;midbody;mitochondrion;nucleoplasm;nucleus;trans-Golgi network","Arginine and proline metabolism;Glutathione metabolism;Metabolic pathways",null,null,9,9,9,"22.5","22.5","22.5","56.166",0,"60.366",915680000,52,"1.03637","0.300576","-0.351318","-3.06557","sp|P28838|AMPL_HUMAN;tr|H0Y9Q1|H0Y9Q1_HUMAN","sp|P28838|AMPL_HUMAN;tr|H0Y9Q1|H0Y9Q1_HUMAN",840,"P28838","AMPL_HUMAN","Cytosol aminopeptidase",null,"LAP3"]
["19.5441","20.0035","20.5017","19.7486",{"$nulls":3},"angiogenesis;apoptotic process;cell differentiation;negative regulation of apoptotic process;nuclear import;regulation of angiogenesis;regulation of transcription from RNA polymerase II promoter;viral process","oxidoreductase activity;transcription coactivator activity","cytoplasm;cytosol;membrane;nuclear envelope;nucleus",{"$nulls":3},3,3,3,"13.2","13.2","13.2","27.049",0,"6.2666",159530000,8,"0.293142","0.737886","-0.351421","-0.796723","sp|Q9BUP3|HTAI2_HUMAN;tr|E9PI87|E9PI87_HUMAN","sp|Q9BUP3|HTAI2_HUMAN;tr|E9PI87|E9PI87_HUMAN",2460,"Q9BUP3","HTAI2_HUMAN","Oxidoreductase HTATIP2",null,"HTATIP2"]
["20.0802","19.935","20.9426","19.7755",{"$nulls":5},"extracellular exosome;integral component of membrane;Sec61 translocon complex","Protein processing in endoplasmic reticulum",null,null,1,1,1,"7.5","7.5","7.5","18.998","0.00038805","3.1062",92696000,6,"0.214158","0.807642","-0.35144","-0.59767","sp|P51571|SSRD_HUMAN","sp|P51571|SSRD_HUMAN",1137,"P51571","SSRD_HUMAN","Translocon-associated protein subunit delta","RAP-delta","SSR4"]
["15.7155","15.7498","16.1907","15.9775",{"$nulls":4},"actin filament binding;ATP binding;motor activity","cardiac myofibril;membrane;myosin filament","Tight junction",null,null,2,2,2,"1.4","1.4","1.4","221.39",0,"18.724",58873000,14,"1.08177","0.309795","-0.351448","-3.25473","sp|A7E2Y1|MYH7B_HUMAN;tr|A0A087X0T3|A0A087X0T3_HUMAN","sp|A7E2Y1|MYH7B_HUMAN;tr|A0A087X0T3|A0A087X0T3_HUMAN",109,"A7E2Y1","MYH7B_HUMAN","Myosin-7B",null,"MYH7B"]
["17.5883","17.4213","18.3307","17.3825",{"$nulls":3},"chemical synaptic transmission;endothelial cell migration;glutamate secretion;G-protein coupled receptor signaling pathway;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of cytokinesis;positive regulation of transforming growth factor beta receptor signaling pathway;protein targeting;regulation of protein stability;regulation of synaptic plasticity","actin binding;cadherin binding;myosin binding;PDZ domain binding;protein homodimerization activity;receptor binding","brush border;cell cortex;cytoplasm;cytoplasmic vesicle;cytosol;dendritic shaft;dendritic spine;endocytic vesicle;extracellular exosome;membrane;synaptic vesicle;vesicle membrane",{"$nulls":3},3,3,3,"18.6","18.6","18.6","36.049",0,"15.274",54679000,10,"0.266879","0.75528","-0.351811","-0.730828","sp|O14908|GIPC1_HUMAN;tr|K7ELJ2|K7ELJ2_HUMAN;tr|K7EM11|K7EM11_HUMAN","sp|O14908|GIPC1_HUMAN",179,"O14908","GIPC1_HUMAN","PDZ domain-containing protein GIPC1",null,"GIPC1"]
["26.1464","25.8548","26.6617","26.0451",{"$nulls":3},"actin filament organization;ATP biosynthetic process;binding of sperm to zona pellucida;canonical glycolysis;fructose 1,6-bisphosphate metabolic process;fructose metabolic process;gluconeogenesis;glycolytic process;muscle cell cellular homeostasis;neutrophil degranulation;platelet degranulation;protein homotetramerization;regulation of cell shape;striated muscle contraction","actin binding;cadherin binding;cytoskeletal protein binding;fructose binding;fructose-bisphosphate aldolase activity;identical protein binding;RNA binding;tubulin binding","actin cytoskeleton;cytosol;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;I band;M band;membrane;nucleus;platelet alpha granule lumen;secretory granule lumen;sperm head;tertiary granule lumen","Biosynthesis of amino acids;Carbon metabolism;Fructose and mannose metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Pentose phosphate pathway",null,null,24,24,21,"75.3","75.3","63.2","39.42",0,"323.31",18499000000,316,"0.387642","0.633932","-0.352796","-1.0345","sp|P04075|ALDOA_HUMAN;tr|J3KPS3|J3KPS3_HUMAN;tr|H3BQN4|H3BQN4_HUMAN;tr|H3BPS8|H3BPS8_HUMAN;tr|H3BUH7|H3BUH7_HUMAN;tr|H3BR04|H3BR04_HUMAN;tr|H3BMQ8|H3BMQ8_HUMAN;tr|H3BR68|H3BR68_HUMAN;tr|H3BU78|H3BU78_HUMAN;tr|A0A087WXX2|A0A087WXX2_HUMAN;sp|P05062|ALDOB_HUMAN","sp|P04075|ALDOA_HUMAN;tr|J3KPS3|J3KPS3_HUMAN;tr|H3BQN4|H3BQN4_HUMAN;tr|H3BPS8|H3BPS8_HUMAN",490,"P04075","ALDOA_HUMAN","Fructose-bisphosphate aldolase A",null,"ALDOA"]
["18.7023","18.313","19.2173","18.5036",{"$nulls":3},"arginyl-tRNA aminoacylation","arginine-tRNA ligase activity;ATP binding","cytoplasm","Spliceosome",null,null,3,3,3,"30.1","30.1","30.1","19.181",0,"3.6315",42328000,6,"0.321562","0.709932","-0.352819","-0.867977","sp|Q8WUD4|CCD12_HUMAN;tr|J3KR35|J3KR35_HUMAN;tr|S4R331|S4R331_HUMAN;tr|C9JUN5|C9JUN5_HUMAN","sp|Q8WUD4|CCD12_HUMAN;tr|J3KR35|J3KR35_HUMAN",2137,"Q8WUD4","CCD12_HUMAN","Coiled-coil domain-containing protein 12",null,"CCDC12"]
["19.0427","19.5311","19.9349","19.3447",{"$nulls":3},"ATP hydrolysis coupled proton transport;insulin receptor signaling pathway;ion transmembrane transport;phagosome acidification;proton transport;regulation of macroautophagy;transferrin transport","hydrogen-exporting ATPase activity, phosphorylative mechanism;proton-transporting ATPase activity, rotational mechanism;transporter activity","apical part of cell;cytoplasmic vesicle;cytosol;extracellular exosome;lysosomal membrane;plasma membrane;proton-transporting two-sector ATPase complex;vacuolar proton-transporting V-type ATPase, V1 domain","Collecting duct acid secretion;Epithelial cell signaling in Helicobacter pylori infection;Human papillomavirus infection;Metabolic pathways;mTOR signaling pathway;Oxidative phosphorylation;Phagosome;Rheumatoid arthritis;Synaptic vesicle cycle;Vibrio cholerae infection",null,null,5,5,5,"12.6","12.6","12.6","43.941",0,"4.7495",186370000,8,"0.342767","0.692029","-0.352878","-0.921224","sp|P21283|VATC1_HUMAN;tr|E7EV59|E7EV59_HUMAN","sp|P21283|VATC1_HUMAN;tr|E7EV59|E7EV59_HUMAN",752,"P21283","VATC1_HUMAN","V-type proton ATPase subunit C 1","-ATPase subunit C 1","ATP6V1C1"]
["16.7526","16.6315","17.7142","16.376",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;cargo loading into COPII-coated vesicle;COPII vesicle coating;ER to Golgi vesicle-mediated transport;intracellular protein transport;positive regulation of cholesterol homeostasis;positive regulation of protein secretion;regulation of low-density lipoprotein particle receptor biosynthetic process","zinc ion binding","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane","Protein processing in endoplasmic reticulum",null,null,4,4,4,"5.7","5.7","5.7","119.75",0,"5.9852",56015000,12,"0.185923","0.834626","-0.352982","-0.525398","sp|O95486|SC24A_HUMAN;tr|H0Y9J6|H0Y9J6_HUMAN","sp|O95486|SC24A_HUMAN",438,"O95486","SC24A_HUMAN","Protein transport protein Sec24A {ECO:0000305}",null,"SEC24A"]
["20.0332","18.2898","20.6645","18.3654",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;insulin receptor signaling pathway;intracellular protein transport","protein transporter activity;transporter activity","AP-3 adaptor complex;AP-type membrane coat adaptor complex;axon cytoplasm;cytoplasmic vesicle membrane;Golgi apparatus;intracellular membrane-bounded organelle;transport vesicle","Lysosome",null,null,2,2,2,"13.5","13.5","13.5","21.732",0,"28.974",89871000,12,"0.0812814","0.929119","-0.353435","-0.244983","sp|Q92572|AP3S1_HUMAN;tr|F5H459|F5H459_HUMAN","sp|Q92572|AP3S1_HUMAN;tr|F5H459|F5H459_HUMAN",2173,"Q92572","AP3S1_HUMAN","AP-3 complex subunit sigma-1",null,"AP3S1"]
["20.0531","20.2389","20.4178","20.5833",{"$nulls":3},"glycerophospholipid biosynthetic process",null,"mitochondrion",{"$nulls":3},5,5,5,"19.1","19.1","19.1","46.321",0,"49.511",236950000,31,"0.982105","0.296515","-0.354585","-2.85023","sp|Q9BXW7|CECR5_HUMAN;tr|A8MYZ9|A8MYZ9_HUMAN","sp|Q9BXW7|CECR5_HUMAN",2502,"Q9BXW7","HDHD5_HUMAN","Haloacid dehalogenase-like hydrolase domain-containing 5 {ECO:0000312|HGNC:HGNC:1843}",null,"HDHD5"]
["24.4124","22.9733","24.8266","23.2686",{"$nulls":5},"cytosol;nucleoplasm",{"$nulls":3},2,2,2,"22.4","22.4","22.4","11.758",0,"62.98",673030000,19,"0.113621","0.904136","-0.354762","-0.334533","tr|B8ZZQ6|B8ZZQ6_HUMAN;sp|P06454|PTMA_HUMAN;tr|B8ZZA1|B8ZZA1_HUMAN;tr|B8ZZW7|B8ZZW7_HUMAN;tr|H7C2N1|H7C2N1_HUMAN","tr|B8ZZQ6|B8ZZQ6_HUMAN;sp|P06454|PTMA_HUMAN;tr|B8ZZA1|B8ZZA1_HUMAN;tr|B8ZZW7|B8ZZW7_HUMAN;tr|H7C2N1|H7C2N1_HUMAN",527,"B8ZZQ6","B8ZZQ6_HUMAN",null,null,"PTMA"]
["17.6559","17.4422","18.0564","17.7514",{"$nulls":3},"metabolic process","catalytic activity","cytoplasm;extracellular exosome;membrane;nucleus",{"$nulls":3},2,2,2,"2.2","2.2","2.2","171.49",0,"38.704",160820000,16,"0.705704","0.363382","-0.354878","-1.90598","sp|Q9P265|DIP2B_HUMAN","sp|Q9P265|DIP2B_HUMAN",2782,"Q9P265","DIP2B_HUMAN","Disco-interacting protein 2 homolog B","IP2 homolog B","DIP2B"]
["22.8372","22.6144","23.1839","22.9786",{"$nulls":3},"autophagy of mitochondrion;calcium-mediated signaling using intracellular calcium source;cellular response to glucose stimulus;cellular response to peptide;cellular response to thapsigargin;cellular response to toxic substance;mitochondrial fission;mitochondrial fragmentation involved in apoptotic process;mitochondrial fusion;mitochondrion morphogenesis;negative regulation of endoplasmic reticulum calcium ion concentration;peroxisome fission;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cytosolic calcium ion concentration;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial calcium ion concentration;positive regulation of mitochondrial fission;positive regulation of neuron apoptotic process;positive regulation of protein targeting to membrane;protein homooligomerization;protein targeting to mitochondrion;regulation of mitochondrion organization;release of cytochrome c from mitochondria;response to flavonoid;response to fluoride;response to hypobaric hypoxia;response to muscle activity;response to nutrient levels","protein complex binding;receptor binding","endoplasmic reticulum;integral component of mitochondrial outer membrane;integral component of peroxisomal membrane;membrane;mitochondrion;peroxisome;protein complex","Mitophagy - animal",null,null,2,2,2,"19.1","19.1","19.1","16.937",0,"48.954",424590000,17,"0.843118","0.308989","-0.355439","-2.34666","sp|Q9Y3D6|FIS1_HUMAN","sp|Q9Y3D6|FIS1_HUMAN",2984,"Q9Y3D6","FIS1_HUMAN","Mitochondrial fission 1 protein",null,"FIS1"]
["15.7482","15.6647","16.4376","15.6865",{"$nulls":3},"cytoplasmic microtubule organization;cytoskeleton-dependent intracellular transport;early endosome to late endosome transport;endosome organization;endosome to lysosome transport;Golgi localization;interkinetic nuclear migration;lysosome organization;microtubule anchoring at centrosome;negative regulation of neurogenesis;neuronal stem cell population maintenance;protein localization to centrosome;protein transport","dynein light intermediate chain binding;identical protein binding;microtubule binding","centriolar satellite;centrosome;cis-Golgi network;cytosol;FHF complex;Golgi apparatus;microtubule;pericentriolar material",{"$nulls":3},2,2,2,4,4,4,"83.125",0,"4.1632",24948000,6,"0.350682","0.685288","-0.355608","-0.941134","sp|Q86VS8|HOOK3_HUMAN","sp|Q86VS8|HOOK3_HUMAN",1990,"Q86VS8","HOOK3_HUMAN","Protein Hook homolog 3","HK3;-hook3","HOOK3"]
["18.4509","17.9705","18.8981","18.2357",{"$nulls":3},"cell cycle;regulation of bone mineralization;regulation of cell cycle;regulation of cell cycle process;regulation of transcription, DNA-templated;transcription, DNA-templated","protein heterodimerization activity;syntaxin binding","cytosol;nuclear membrane",{"$nulls":3},4,4,4,10,10,10,"60.585",0,"8.3619",80750000,3,"0.322618","0.708058","-0.356236","-0.870626","sp|Q9NUQ3|TXLNG_HUMAN","sp|Q9NUQ3|TXLNG_HUMAN",2707,"Q9NUQ3","TXLNG_HUMAN","Gamma-taxilin",null,"TXLNG"]
["14.5693","14.164","15.4887","13.958",{"$nulls":5},"cytosol;intracellular membrane-bounded organelle;nucleolus;WASH complex",{"$nulls":3},10,1,1,"14.3","1.9","1.9","138.01",0,"22.737",14720000,3,"0.157094","0.868466","-0.356666","-0.4505","tr|J3KP36|J3KP36_HUMAN;sp|Q9Y4E1|FA21C_HUMAN;tr|A0A0A0MR88|A0A0A0MR88_HUMAN;tr|A0A096LPC5|A0A096LPC5_HUMAN","tr|J3KP36|J3KP36_HUMAN;sp|Q9Y4E1|FA21C_HUMAN;tr|A0A0A0MR88|A0A0A0MR88_HUMAN;tr|A0A096LPC5|A0A096LPC5_HUMAN",2996,"J3KP36","J3KP36_HUMAN",null,null,"WASHC2C"]
["20.5067","20.4781","20.971","20.7285",{"$nulls":3},"axon guidance;cell differentiation;gonadotropin secretion;hypomethylation of CpG island;negative regulation of angiogenesis;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of DNA biosynthetic process;negative regulation of Notch signaling pathway;negative regulation of transcription, DNA-templated;negative regulation of vascular endothelial growth factor receptor signaling pathway;positive regulation of embryonic development;positive regulation of skeletal muscle fiber development;positive regulation of transcription regulatory region DNA binding;positive regulation of transcription, DNA-templated;RNA folding","cadherin binding;transcription coactivator activity","adherens junction;cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},13,13,13,34,34,34,"84.137",0,"64.75",669480000,41,"1.00178","0.295613","-0.357334","-2.92699","sp|Q96TA1|NIBL1_HUMAN","sp|Q96TA1|NIBL1_HUMAN",2364,"Q96TA1","NIBL1_HUMAN","Niban-like protein 1",null,"FAM129B"]
["19.6779","19.3707","20.2291","19.5346",{"$nulls":3},"4-hydroxyproline metabolic process;animal organ senescence;brown fat cell differentiation;cell redox homeostasis;cellular protein modification process;cellular response to hypoxia;cellular response to oxidative stress;chaperone mediated protein folding requiring cofactor;endoplasmic reticulum unfolded protein response;extracellular matrix organization;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;protein folding;protein folding in endoplasmic reticulum;protein maturation by protein folding;release of sequestered calcium ion into cytosol;response to endoplasmic reticulum stress;response to temperature stimulus","disulfide oxidoreductase activity;oxidoreductase activity;oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;protein disulfide isomerase activity;protein disulfide oxidoreductase activity","dendrite;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;intracellular membrane-bounded organelle;membrane","Protein processing in endoplasmic reticulum;Vibrio cholerae infection",null,null,3,3,2,"7.9","7.9","5.6","54.392",0,"19.008",232420000,8,"0.350803","0.68568","-0.357474","-0.941439","sp|Q96HE7|ERO1A_HUMAN;tr|G3V5B3|G3V5B3_HUMAN;tr|G3V3E6|G3V3E6_HUMAN","sp|Q96HE7|ERO1A_HUMAN",2288,"Q96HE7","ERO1A_HUMAN","ERO1-like protein alpha","RO1-L;RO1-L-alpha","ERO1A"]
["24.4453","24.886","25.1081","24.9393",{"$nulls":3},"apoptotic DNA fragmentation;cell chemotaxis;cellular response to lipopolysaccharide;chromatin organization;defense response to Gram-negative bacterium;defense response to Gram-positive bacterium;DNA geometric change;DNA ligation involved in DNA repair;DNA topological change;inflammatory response to antigenic stimulus;innate immune response;male gonad development;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of transcription, DNA-templated;nucleosome assembly;positive regulation of DNA binding;positive regulation of endothelial cell proliferation;positive regulation of erythrocyte differentiation;positive regulation of innate immune response;positive regulation of interferon-beta production;positive regulation of megakaryocyte differentiation;positive regulation of nuclease activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of neurogenesis;regulation of stem cell proliferation;regulation of transcription from RNA polymerase II promoter;response to drug;response to lipopolysaccharide;response to steroid hormone;spermatid nucleus differentiation;transcription, DNA-templated;V(D)J recombination","chemoattractant activity;damaged DNA binding;DNA binding;DNA binding transcription factor activity;DNA binding, bending;double-stranded DNA binding;drug binding;enhancer sequence-specific DNA binding;four-way junction DNA binding;non-sequence-specific DNA binding, bending;protein domain specific binding;RAGE receptor binding;RNA binding;single-stranded DNA binding;supercoiled DNA binding;transcription factor binding;transcription regulatory region DNA binding","cell;condensed chromosome;cytoplasm;extracellular space;nuclear chromatin;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex",{"$nulls":3},6,5,5,"24.4","18.7","18.7","24.033",0,"38.596",1803900000,30,"0.571203","0.46718","-0.358084","-1.51762","sp|P26583|HMGB2_HUMAN;tr|D6R9A6|D6R9A6_HUMAN","sp|P26583|HMGB2_HUMAN;tr|D6R9A6|D6R9A6_HUMAN",813,"P26583","HMGB2_HUMAN","High mobility group protein B2",null,"HMGB2"]
["17.8052","18.0326","18.8906","17.6651",{"$nulls":3},"biomineral tissue development;intermediate filament cytoskeleton organization;positive regulation of cell migration;protein localization to cytoskeleton","keratin filament binding;protein kinase binding","cytoplasm;cytoskeleton",{"$nulls":3},8,8,8,"9.3","9.3","9.3","127.12",0,"69.357",157580000,28,"0.205643","0.818596","-0.358938","-0.575968","sp|Q6ZRV2|FA83H_HUMAN;tr|J3KPS2|J3KPS2_HUMAN","sp|Q6ZRV2|FA83H_HUMAN;tr|J3KPS2|J3KPS2_HUMAN",1916,"Q6ZRV2","FA83H_HUMAN","Protein FAM83H {ECO:0000305}",null,"FAM83H"]
["21.9353","21.9603","22.417","22.1969",{"$nulls":3},"adult locomotory behavior;cerebellar Purkinje cell layer maturation;ER to Golgi vesicle-mediated transport;intracellular protein transport;pigmentation;retrograde vesicle-mediated transport, Golgi to ER","RNA binding","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi membrane;membrane;transport vesicle",{"$nulls":3},9,9,9,"23.5","23.5","23.5","57.21",0,"92.907",1227200000,60,"1.0787","0.304588","-0.359141","-3.2417","sp|P48444|COPD_HUMAN;tr|B0YIW6|B0YIW6_HUMAN;tr|Q6P1Q5|Q6P1Q5_HUMAN","sp|P48444|COPD_HUMAN;tr|B0YIW6|B0YIW6_HUMAN",1052,"P48444","COPD_HUMAN","Coatomer subunit delta",null,"ARCN1"]
["21.0443","21.2078","21.5272","21.4432",{"$nulls":3},"negative regulation of mitochondrial fusion;neutrophil degranulation","oxidoreductase activity;zinc ion binding","azurophil granule lumen;extracellular exosome;extracellular region;integral component of membrane;mitochondrial outer membrane",{"$nulls":3},7,7,7,"28.5","28.5","28.5","41.92",0,"23.278",417460000,37,"1.22407","0.316813","-0.359156","-3.90739","sp|Q99536|VAT1_HUMAN;tr|K7ERT7|K7ERT7_HUMAN;tr|K7ESA3|K7ESA3_HUMAN;tr|K7ENX2|K7ENX2_HUMAN;tr|K7EM19|K7EM19_HUMAN;tr|K7ER81|K7ER81_HUMAN","sp|Q99536|VAT1_HUMAN;tr|K7ERT7|K7ERT7_HUMAN",2379,"Q99536","VAT1_HUMAN","Synaptic vesicle membrane protein VAT-1 homolog",null,"VAT1"]
["22.6253","21.2502","22.4274","22.1667",{"$nulls":3},"fatty acid beta-oxidation using acyl-CoA dehydrogenase;protein methylation;respiratory electron transport chain","electron transfer activity","cytosol;extracellular exosome;mitochondrial matrix",{"$nulls":3},5,5,5,"18.4","18.4","18.4","27.843",0,"11.709",547330000,23,"0.181266","0.837881","-0.359271","-0.513386","sp|P38117|ETFB_HUMAN;tr|M0QY67|M0QY67_HUMAN","sp|P38117|ETFB_HUMAN",956,"P38117","ETFB_HUMAN","Electron transfer flavoprotein subunit beta {ECO:0000305}","eta-ETF {ECO:0000303|PubMed:8504797}","ETFB"]
["17.4814","17.4583","18.1929","17.4654",{"$nulls":3},"CAAX-box protein processing;nuclear envelope organization;prenylated protein catabolic process;proteolysis","metal ion binding;metalloendopeptidase activity;metalloexopeptidase activity","extracellular exosome;integral component of endoplasmic reticulum membrane;membrane;nuclear inner membrane","Terpenoid backbone biosynthesis",null,null,1,1,1,"2.3","2.3","2.3","54.812","0.0010993","2.6294",51192000,7,"0.36898","0.659907","-0.359289","-0.987265","sp|O75844|FACE1_HUMAN","sp|O75844|FACE1_HUMAN",370,"O75844","FACE1_HUMAN","CAAX prenyl protease 1 homolog",null,"ZMPSTE24"]
["18.5846","18.8798","19.3109","18.8724",{"$nulls":3},"activation of protein kinase activity;cellular hypotonic response;intracellular signal transduction;negative regulation of potassium ion transmembrane transporter activity;negative regulation of rubidium ion transmembrane transporter activity;peptidyl-threonine phosphorylation;protein phosphorylation;regulation of apoptotic process;regulation of mitotic cell cycle;response to oxidative stress;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;identical protein binding;magnesium ion binding;protein serine/threonine kinase activity;signal transducer, downstream of receptor, with serine/threonine kinase activity","cytoplasm;cytosol;extracellular exosome",{"$nulls":3},3,3,3,"9.1","9.1","9.1","58.022",0,"10.397",111800000,13,"0.513146","0.511567","-0.359461","-1.36017","sp|O95747|OXSR1_HUMAN;tr|C9JIG9|C9JIG9_HUMAN","sp|O95747|OXSR1_HUMAN",447,"O95747","OXSR1_HUMAN","Serine/threonine-protein kinase OSR1",null,"OXSR1"]
["21.5654","21.3206","22.1136","21.4915",{"$nulls":3},"mRNA catabolic process;regulation of angiogenesis","ribonuclease inhibitor activity","angiogenin-PRI complex;cytosol;extracellular exosome;nucleoplasm",{"$nulls":3},5,5,5,"14.5","14.5","14.5","49.973",0,"46.616",807300000,31,"0.403832","0.616769","-0.359525","-1.07566","sp|P13489|RINI_HUMAN;tr|E9PMJ3|E9PMJ3_HUMAN;tr|E9PLZ3|E9PLZ3_HUMAN;tr|E9PIM9|E9PIM9_HUMAN;tr|H0YCR7|H0YCR7_HUMAN;tr|E9PMA9|E9PMA9_HUMAN;tr|E9PMN0|E9PMN0_HUMAN;tr|E9PIK5|E9PIK5_HUMAN","sp|P13489|RINI_HUMAN",655,"P13489","RINI_HUMAN","Ribonuclease inhibitor",null,"RNH1"]
["19.4033","19.6326","19.9686","19.787",{"$nulls":3},"leukocyte migration;negative regulation of cell-cell adhesion mediated by cadherin;positive regulation of cell proliferation;positive regulation of stem cell proliferation;positive regulation of transcription from RNA polymerase II promoter;signal transduction involved in regulation of gene expression;stem cell differentiation;ureteric bud development","cadherin binding involved in cell-cell adhesion;protein complex binding","apical plasma membrane;basolateral plasma membrane;bicellular tight junction;cell surface;extracellular exosome;integral component of plasma membrane;lateral plasma membrane;plasma membrane",{"$nulls":3},3,3,3,"15.9","15.9","15.9","34.932",0,"11.284",111030000,11,"0.876151","0.303715","-0.359866","-2.46058","sp|P16422|EPCAM_HUMAN;tr|B5MCA4|B5MCA4_HUMAN;tr|C9JKY3|C9JKY3_HUMAN","sp|P16422|EPCAM_HUMAN;tr|B5MCA4|B5MCA4_HUMAN",697,"P16422","EPCAM_HUMAN","Epithelial cell adhesion molecule","p-CAM","EPCAM"]
["15.9125","15.6765","16.2061","16.1046",{"$nulls":3},"chondrocyte differentiation involved in endochondral bone morphogenesis;Golgi organization;inner ear receptor stereocilium organization;intraciliary transport involved in cilium assembly;protein glycosylation;transcription from RNA polymerase II promoter;ventricular septum development","transcription coactivator activity","cilium;cis-Golgi network;cytoskeleton;Golgi apparatus;Golgi membrane;inner acrosomal membrane;nuclear speck;nucleus;outer acrosomal membrane;transport vesicle",{"$nulls":3},5,5,5,"4.1","4.1","4.1","227.58",0,"15.796",92311000,19,"0.971445","0.298075","-0.360829","-2.80924","sp|Q15643|TRIPB_HUMAN;tr|H0YJ97|H0YJ97_HUMAN;tr|H0YJI2|H0YJI2_HUMAN","sp|Q15643|TRIPB_HUMAN;tr|H0YJ97|H0YJ97_HUMAN",1712,"Q15643","TRIPB_HUMAN","Thyroid receptor-interacting protein 11","R-interacting protein 11;RIP-11","TRIP11"]
["25.4493","25.1101","25.8139","25.4673",{"$nulls":3},"chaperone-mediated autophagy;chaperone-mediated protein complex assembly;ciliary basal body-plasma membrane docking;ERBB2 signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;G2/M transition of mitotic cell cycle;mitochondrial transport;neutrophil degranulation;positive regulation of nitric oxide biosynthetic process;positive regulation of telomerase activity;protein import into mitochondrial outer membrane;protein refolding;protein stabilization;protein unfolding;receptor-mediated endocytosis;regulation of cellular response to heat;regulation of G2/M transition of mitotic cell cycle;regulation of nitric-oxide synthase activity;regulation of protein complex assembly;regulation of protein ubiquitination;response to antibiotic;response to cold;response to heat;response to unfolded protein;signal transduction;telomerase holoenzyme complex assembly;telomere maintenance via telomerase;vascular endothelial growth factor receptor signaling pathway","ATP binding;ATPase activity;disordered domain specific binding;DNA polymerase binding;GTPase binding;histone deacetylase binding;identical protein binding;MHC class II protein complex binding;nitric-oxide synthase regulator activity;nucleotide binding;protein homodimerization activity;protein tyrosine kinase activity;protein tyrosine kinase binding;RNA binding;TPR domain binding;unfolded protein binding","cytoplasm;cytosol;endocytic vesicle lumen;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;lysosomal lumen;melanosome;membrane;myelin sheath;nucleoplasm;nucleus;plasma membrane;protein complex;ruffle membrane;secretory granule lumen","Antigen processing and presentation;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;IL-17 signaling pathway;Necroptosis;NOD-like receptor signaling pathway;Pathways in cancer;PI3K-Akt signaling pathway;Progesterone-mediated oocyte maturation;Prostate cancer;Protein processing in endoplasmic reticulum;Th17 cell differentiation",null,null,32,20,20,"48.8","33.2","33.2","84.659",0,"323.31",16020000000,263,"0.560555","0.470855","-0.360889","-1.48834","sp|P07900|HS90A_HUMAN;tr|G3V2J8|G3V2J8_HUMAN;sp|Q14568|HS902_HUMAN;sp|Q58FG0|HS905_HUMAN;sp|Q58FG1|HS904_HUMAN","sp|P07900|HS90A_HUMAN",550,"P07900","HS90A_HUMAN","Heat shock protein HSP 90-alpha",null,"HSP90AA1"]
["23.0571","23.0838","23.6003","23.2628",{"$nulls":3},"ATP metabolic process;platelet degranulation","ATP binding;ATPase activity;cadherin binding;GTP binding;metal ion binding","centrosome;cytoplasm;cytosol;extracellular exosome;extracellular region;membrane;nucleolus;platelet alpha granule lumen",{"$nulls":3},14,14,14,"37.4","37.4","37.4","44.743",0,"96.75",2751600000,68,"0.778696","0.336505","-0.361097","-2.13376","sp|Q9NTK5|OLA1_HUMAN;tr|J3KQ32|J3KQ32_HUMAN;tr|C9JCJ9|C9JCJ9_HUMAN;tr|C9JTK6|C9JTK6_HUMAN","sp|Q9NTK5|OLA1_HUMAN;tr|J3KQ32|J3KQ32_HUMAN",2700,"Q9NTK5","OLA1_HUMAN","Obg-like ATPase 1 {ECO:0000255|HAMAP-Rule:MF_03167}",null,"OLA1"]
["18.4107","18.8635","19.0964","18.9047",{"$nulls":3},"blastocyst growth;endodermal cell fate commitment;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of histone H3-K4 methylation;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein ubiquitination;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;Wnt signaling pathway","RNA binding;RNA polymerase II C-terminal domain phosphoserine binding;single-stranded DNA binding;transcription factor activity, RNA polymerase II transcription factor binding","Cdc73/Paf1 complex;nucleolus;nucleoplasm",{"$nulls":3},4,4,4,"5.4","5.4","5.4","80.313",0,"15.492",136540000,11,"0.556914","0.470206","-0.363471","-1.47837","sp|Q92541|RTF1_HUMAN;tr|H0YKX1|H0YKX1_HUMAN","sp|Q92541|RTF1_HUMAN",2170,"Q92541","RTF1_HUMAN","RNA polymerase-associated protein RTF1 homolog",null,"RTF1"]
["18.5563","18.3928","19.5896","18.0865",{"$nulls":3},"actin cytoskeleton organization;chemical synaptic transmission;ephrin receptor signaling pathway;intracellular signal transduction;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of receptor internalization;neutrophil degranulation;positive regulation of cell growth;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of epithelial to mesenchymal transition;positive regulation of exosomal secretion;positive regulation of extracellular exosome assembly;positive regulation of JNK cascade;positive regulation of pathway-restricted SMAD protein phosphorylation;positive regulation of phosphorylation;positive regulation of transforming growth factor beta receptor signaling pathway;protein targeting to membrane;regulation of mitotic cell cycle;substrate-dependent cell migration, cell extension","cadherin binding;cytoskeletal adaptor activity;frizzled binding;identical protein binding;interleukin-5 receptor binding;phosphatidylinositol-4,5-bisphosphate binding;protein heterodimerization activity;protein N-terminus binding;syndecan binding","adherens junction;azurophil granule lumen;blood microparticle;cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum membrane;extracellular exosome;extracellular region;extracellular space;extracellular vesicle;focal adhesion;interleukin-5 receptor complex;intracellular membrane-bounded organelle;melanosome;membrane;membrane raft;nuclear membrane;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},3,3,1,"23.8","23.8",6,"32.444",0,"12.707",65697000,19,"0.168727","0.852995","-0.363519","-0.480881","sp|O00560|SDCB1_HUMAN;tr|B4DHN5|B4DHN5_HUMAN;tr|E9PBU7|E9PBU7_HUMAN","sp|O00560|SDCB1_HUMAN",151,"O00560","SDCB1_HUMAN","Syntenin-1",null,"SDCBP"]
["18.4549","18.404","18.8102","18.7767",{"$nulls":4},"metal ion binding;phosphoprotein phosphatase activity",{"$nulls":4},5,1,1,"17.8","3.3","3.3","34.95",0,"4.0103",68125000,7,"2.1589","0.423667","-0.364017","-11.9448","tr|F8VYE8|F8VYE8_HUMAN;sp|P36873|PP1G_HUMAN;tr|F8W0W8|F8W0W8_HUMAN;tr|A0A087WYY5|A0A087WYY5_HUMAN;tr|F8VR82|F8VR82_HUMAN","tr|F8VYE8|F8VYE8_HUMAN;sp|P36873|PP1G_HUMAN;tr|F8W0W8|F8W0W8_HUMAN;tr|A0A087WYY5|A0A087WYY5_HUMAN;tr|F8VR82|F8VR82_HUMAN",949,"F8VYE8","F8VYE8_HUMAN","Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273}",null,"PPP1CC"]
["25.1628","25.0301","25.4815","25.4395",{"$nulls":5},"membrane;mitochondrion",{"$nulls":3},14,14,14,55,55,55,"33.239",0,"303.87",6905800000,90,"1.46033","0.32171","-0.364085","-5.23172","tr|J3KPX7|J3KPX7_HUMAN;sp|Q99623|PHB2_HUMAN;tr|F5GY37|F5GY37_HUMAN;tr|F5GWA7|F5GWA7_HUMAN;tr|F5H3X6|F5H3X6_HUMAN;tr|F5H0C5|F5H0C5_HUMAN;tr|F5H2D2|F5H2D2_HUMAN;tr|U3KPZ5|U3KPZ5_HUMAN","tr|J3KPX7|J3KPX7_HUMAN;sp|Q99623|PHB2_HUMAN;tr|F5GY37|F5GY37_HUMAN;tr|F5GWA7|F5GWA7_HUMAN;tr|F5H3X6|F5H3X6_HUMAN",2390,"J3KPX7","J3KPX7_HUMAN",null,null,"PHB2"]
["17.4996","17.3884","17.9856","17.6314",{"$nulls":4},"transferase activity, transferring glycosyl groups","endoplasmic reticulum membrane",{"$nulls":3},1,1,1,"7.7","7.7","7.7","24.198","0.00040161","3.4005",21829000,9,"0.724625","0.353473","-0.364492","-1.96375","tr|H0YCW6|H0YCW6_HUMAN;sp|Q9H6U8|ALG9_HUMAN;tr|A0A087WZ62|A0A087WZ62_HUMAN","tr|H0YCW6|H0YCW6_HUMAN;sp|Q9H6U8|ALG9_HUMAN;tr|A0A087WZ62|A0A087WZ62_HUMAN",2606,"H0YCW6","H0YCW6_HUMAN","Mannosyltransferase {ECO:0000256|RuleBase:RU363075}",null,"ALG9"]
["13.8057","14.185","14.6595","14.0607",{"$nulls":3},"actin filament capping;adult behavior;antigen processing and presentation of exogenous peptide antigen via MHC class II;axon guidance;cerebellar Purkinje cell layer morphogenesis;ER to Golgi vesicle-mediated transport;MAPK cascade;multicellular organism growth;synapse assembly;vesicle-mediated transport","actin binding;cadherin binding;phospholipid binding;Ras guanyl-nucleotide exchange factor activity;structural constituent of cytoskeleton","apical plasma membrane;cell junction;cytosol;extracellular space;neuronal cell body;spectrin",{"$nulls":3},5,2,2,"2.6","1.1","1.1","271.32",0,"9.478",32220000,10,"0.385499","0.63423","-0.364708","-1.02906","sp|O15020|SPTN2_HUMAN","sp|O15020|SPTN2_HUMAN",191,"O15020","SPTN2_HUMAN","Spectrin beta chain, non-erythrocytic 2",null,"SPTBN2"]
["18.3688","18.0549","18.8883","18.2656",{"$nulls":3},"actin filament-based movement;actomyosin structure organization;mitochondrion morphogenesis;neuronal action potential;regulation of cell shape;sensory perception of sound;skeletal muscle contraction;skeletal muscle tissue development;vocalization behavior","actin filament binding;actin-dependent ATPase activity;ATP binding;ATPase activity;calmodulin binding;microfilament motor activity","actomyosin;axon;brush border;cytosol;extracellular exosome;growth cone;membrane;myelin sheath;myosin II complex;myosin II filament;stress fiber","Regulation of actin cytoskeleton;Tight junction",null,null,9,3,3,5,"2.1","2.1","227.87",0,"8.9157",455950000,5,"0.392605","0.627113","-0.365106","-1.0471","sp|Q7Z406|MYH14_HUMAN;tr|M0QY43|M0QY43_HUMAN","sp|Q7Z406|MYH14_HUMAN;tr|M0QY43|M0QY43_HUMAN",1950,"Q7Z406","MYH14_HUMAN","Myosin-14",null,"MYH14"]
["22.0939","21.7847","22.3639","22.2458",{"$nulls":3},"nucleosome assembly","nucleosome binding;RNA binding;unfolded protein binding","cytoplasm;nucleus",{"$nulls":3},10,10,8,"35.5","35.5","32.5","42.823",0,"164.78",738390000,49,"0.801829","0.328151","-0.365527","-2.20885","sp|Q99733|NP1L4_HUMAN;tr|E9PS34|E9PS34_HUMAN;tr|E9PNJ7|E9PNJ7_HUMAN;tr|C9J6D1|C9J6D1_HUMAN;tr|C9JZI7|C9JZI7_HUMAN;tr|E9PNW0|E9PNW0_HUMAN;tr|E9PJJ2|E9PJJ2_HUMAN;tr|A8MXH2|A8MXH2_HUMAN;tr|E9PKT8|E9PKT8_HUMAN;tr|E9PKI2|E9PKI2_HUMAN;tr|E9PP22|E9PP22_HUMAN;tr|C9J1B1|C9J1B1_HUMAN;tr|H0YCI4|H0YCI4_HUMAN","sp|Q99733|NP1L4_HUMAN;tr|E9PS34|E9PS34_HUMAN;tr|E9PNJ7|E9PNJ7_HUMAN;tr|C9J6D1|C9J6D1_HUMAN;tr|C9JZI7|C9JZI7_HUMAN;tr|E9PNW0|E9PNW0_HUMAN;tr|E9PJJ2|E9PJJ2_HUMAN;tr|A8MXH2|A8MXH2_HUMAN;tr|E9PKT8|E9PKT8_HUMAN",2394,"Q99733","NP1L4_HUMAN","Nucleosome assembly protein 1-like 4",null,"NAP1L4"]
["17.2683","17.2143","17.3247","17.8891",{"$nulls":3},"autophagy;negative regulation of clathrin-dependent endocytosis;negative regulation of G-protein coupled receptor internalization;positive regulation of ER-associated ubiquitin-dependent protein catabolic process;regulation of autophagosome assembly;regulation of macroautophagy;ubiquitin-dependent ERAD pathway",null,"autophagosome;cytoplasm;cytoplasmic vesicle;cytosol;nucleus;plasma membrane","Protein processing in endoplasmic reticulum",null,null,1,1,1,"2.6","2.6","2.6","65.695",0,"28.284",27136000,8,"0.486634","0.522602","-0.365614","-1.2899","sp|Q9UHD9|UBQL2_HUMAN","sp|Q9UHD9|UBQL2_HUMAN",2832,"Q9UHD9","UBQL2_HUMAN","Ubiquilin-2",null,"UBQLN2"]
["19.9676","20.0608","20.6886","20.0712",{"$nulls":3},"protein targeting to ER;response to drug;SRP-dependent cotranslational protein targeting to membrane","7S RNA binding;endoplasmic reticulum signal peptide binding;protein domain specific binding;RNA binding;signal recognition particle binding","cytosol;endoplasmic reticulum;focal adhesion;nucleolus;ribosome;signal recognition particle;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,9,9,9,"16.6","16.6","16.6","70.729",0,"44.86",408950000,29,"0.441119","0.562713","-0.36568","-1.17128","sp|Q9UHB9|SRP68_HUMAN","sp|Q9UHB9|SRP68_HUMAN",2828,"Q9UHB9","SRP68_HUMAN","Signal recognition particle subunit SRP68","RP68","SRP68"]
["19.4737","19.3341","19.8625","19.6766",{"$nulls":3},"DNA catabolic process, exonucleolytic;DNA-templated transcription, termination;hippocampus development;mRNA processing;neuron differentiation;regulation of transcription, DNA-templated;retina development in camera-type eye;RNA catabolic process;RNA metabolic process;RNA processing;rRNA processing;spermatogenesis","3'-5'-exoribonuclease activity;5'-3' exonuclease activity;5'-3' exoribonuclease activity;metal ion binding;nuclease activity;RNA binding;transcription termination site sequence-specific DNA binding","aggresome;membrane;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes;RNA degradation",null,null,8,8,8,"10.6","10.6","10.6","108.58",0,"30.228",350520000,44,"1.05571","0.306373","-0.36569","-3.14509","sp|Q9H0D6|XRN2_HUMAN","sp|Q9H0D6|XRN2_HUMAN",2557,"Q9H0D6","XRN2_HUMAN","5'-3' exoribonuclease 2",null,"XRN2"]
["20.6858","20.1859","21.2531","20.3502",{"$nulls":3},"apical protein localization;barbed-end actin filament capping;cellular response to platelet-derived growth factor stimulus;cellular response to thyroid hormone stimulus;establishment of endothelial barrier;establishment of protein localization;microvillus assembly;negative regulation of adherens junction organization;negative regulation of cell size;negative regulation of GTPase activity;negative regulation of homotypic cell-cell adhesion;positive regulation of cell migration;positive regulation of cellular protein catabolic process;positive regulation of early endosome to late endosome transport;positive regulation of G1/S transition of mitotic cell cycle;positive regulation of gene expression;positive regulation of protein localization to early endosome;protein kinase A signaling;protein localization to plasma membrane;regulation of actin filament bundle assembly;regulation of cell shape;regulation of cell size;regulation of GTPase activity;regulation of organelle assembly;regulation of Rap protein signal transduction;regulation of ruffle assembly","actin binding;ATPase binding;cadherin binding;protein domain specific binding;protein homodimerization activity;protein kinase A binding;RNA binding","apical plasma membrane;cell periphery;cell tip;cell-cell adherens junction;cleavage furrow;cortical actin cytoskeleton;extracellular exosome;extracellular space;filopodium;focal adhesion;lamellipodium;microvillus;midbody;myelin sheath;plasma membrane;ruffle;stereocilium;T-tubule","MicroRNAs in cancer;Proteoglycans in cancer;Regulation of actin cytoskeleton;Tight junction",null,null,9,3,3,17,7,7,"68.563",0,"33.007",554880000,19,"0.258183","0.766519","-0.365822","-0.70897","sp|P35241|RADI_HUMAN;tr|E9PKN5|E9PKN5_HUMAN","sp|P35241|RADI_HUMAN",924,"P35241","RADI_HUMAN","Radixin",null,"RDX"]
["14.6861","13.6133","13.6116","15.4213",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;replication fork processing",null,"chromosome;nucleoplasm",{"$nulls":3},3,3,3,"1.6","1.6","1.6","330.46",0,"10.875",36037000,8,"0.118825","0.903895","-0.366748","-0.348651","sp|Q8NFC6|BD1L1_HUMAN;tr|H0Y9Y2|H0Y9Y2_HUMAN","sp|Q8NFC6|BD1L1_HUMAN",2094,"Q8NFC6","BD1L1_HUMAN","Biorientation of chromosomes in cell division protein 1-like 1 {ECO:0000305}",null,"BOD1L1"]
["18.8764","18.5384","19.4108","18.7379",{"$nulls":3},"signal transduction","GTPase activator activity","cytosol;nucleoplasm",{"$nulls":3},6,6,6,"6.5","6.5","6.5","120.74",0,"74.362",274320000,16,"0.364009","0.665473","-0.366962","-0.974717","tr|B7ZM87|B7ZM87_HUMAN;tr|A2RUF3|A2RUF3_HUMAN;sp|O75044|SRGP2_HUMAN;tr|A0A075B7B5|A0A075B7B5_HUMAN;tr|Q5VZB4|Q5VZB4_HUMAN;tr|A0A075B7E6|A0A075B7E6_HUMAN;tr|A0A075B7E9|A0A075B7E9_HUMAN;sp|P0DMP2|SRG2B_HUMAN;sp|P0DJJ0|SRG2C_HUMAN;tr|G5EA48|G5EA48_HUMAN;sp|Q7Z6B7|SRGP1_HUMAN","tr|B7ZM87|B7ZM87_HUMAN;tr|A2RUF3|A2RUF3_HUMAN;sp|O75044|SRGP2_HUMAN;tr|A0A075B7B5|A0A075B7B5_HUMAN;tr|Q5VZB4|Q5VZB4_HUMAN",316,"B7ZM87","B7ZM87_HUMAN"]
["18.9114",1,"19.6456",1,{"$nulls":3},"autophagosome assembly;autophagy;cargo loading into COPII-coated vesicle;cell migration;COPII vesicle coating;defense response to bacterium;endocytosis;ER to Golgi vesicle-mediated transport;Golgi organization;growth hormone secretion;interleukin-8 secretion;melanosome transport;positive regulation of glycoprotein metabolic process;positive regulation of ubiquitin protein ligase activity;post-translational protein modification;retrograde vesicle-mediated transport, Golgi to ER;substrate adhesion-dependent cell spreading;vesicle transport along microtubule;vesicle-mediated transport;virion assembly","cadherin binding;GTP binding;GTPase activity","cytosol;early endosome;endoplasmic reticulum membrane;extracellular exosome;Golgi apparatus;Golgi membrane;melanosome;transport vesicle membrane","Legionellosis",null,null,6,1,1,"40.5","8.3","8.3","22.677",0,"39.37",61168000,6,"0.00880814","0.984464","-0.367129","-0.0283992","sp|P62820|RAB1A_HUMAN;tr|E7END7|E7END7_HUMAN","sp|P62820|RAB1A_HUMAN;tr|E7END7|E7END7_HUMAN",1315,"P62820","RAB1A_HUMAN","Ras-related protein Rab-1A",null,"RAB1A"]
["16.5996","16.4571","17.1276","16.6639",{"$nulls":3},"snRNA processing;snRNA transcription from RNA polymerase II promoter","metal ion binding","integrator complex;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"5.8","5.8","5.8","48.807","0.00039262","3.2063",21245000,2,"0.570121","0.466016","-0.367374","-1.51463","sp|Q96CB8|INT12_HUMAN;tr|A0A087WXN4|A0A087WXN4_HUMAN","sp|Q96CB8|INT12_HUMAN;tr|A0A087WXN4|A0A087WXN4_HUMAN",2245,"Q96CB8","INT12_HUMAN","Integrator complex subunit 12","nt12","INTS12"]
["22.4866","21.9198","22.8312","22.3104",{"$nulls":3},"brain development;L-serine biosynthetic process","electron transfer activity;L-malate dehydrogenase activity;NAD binding;phosphoglycerate dehydrogenase activity","cytosol;extracellular exosome","Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways",null,null,11,11,11,"25.1","25.1","25.1","56.65",0,"140.31",1332400000,60,"0.356173","0.677241","-0.367588","-0.954962","sp|O43175|SERA_HUMAN;tr|Q5SZU1|Q5SZU1_HUMAN","sp|O43175|SERA_HUMAN;tr|Q5SZU1|Q5SZU1_HUMAN",233,"O43175","SERA_HUMAN","D-3-phosphoglycerate dehydrogenase",{"$f":"-PGDH","v":{"$error":"#NAME?"}},"PHGDH"]
["19.1555","19.1972","20.9574","18.1344",{"$nulls":3},"cell volume homeostasis;chloride transport;spliceosomal snRNP assembly","protein heterodimerization activity;RNA binding","cytoskeleton;cytosol;methylosome;nucleoplasm;nucleus;pICln-Sm protein complex;plasma membrane","RNA transport",null,null,4,4,4,"38.4","38.4","38.4","26.215",0,"21.025",50629000,11,"0.0872608","0.925423","-0.369574","-0.261798","sp|P54105|ICLN_HUMAN;tr|E9PMI6|E9PMI6_HUMAN;tr|J3KN38|J3KN38_HUMAN;tr|E9PJF4|E9PJF4_HUMAN","sp|P54105|ICLN_HUMAN;tr|E9PMI6|E9PMI6_HUMAN;tr|J3KN38|J3KN38_HUMAN;tr|E9PJF4|E9PJF4_HUMAN",1188,"P54105","ICLN_HUMAN","Methylosome subunit pICln",null,"CLNS1A"]
["15.5399","15.7135","16.5336","15.4598",{"$nulls":3},"endocytosis;protein transport",null,"cytosol;endosome;plasma membrane",{"$nulls":3},2,2,2,"2.8","2.8","2.8","140.02",0,"11.826",45940000,15,"0.246774","0.782036","-0.369996","-0.680242","sp|Q8NDI1|EHBP1_HUMAN;tr|H7BZ98|H7BZ98_HUMAN","sp|Q8NDI1|EHBP1_HUMAN;tr|H7BZ98|H7BZ98_HUMAN",2090,"Q8NDI1","EHBP1_HUMAN","EH domain-binding protein 1",null,"EHBP1"]
["19.784","20.5187","20.7719","20.273",{"$nulls":3},"transport along microtubule","dynein complex binding","actin cytoskeleton;centrosome;cytosol;dynactin complex",{"$nulls":3},13,13,13,13,13,13,"139.09",0,"124.19",940080000,72,"0.308667","0.717314","-0.371072","-0.83564","tr|E7EX90|E7EX90_HUMAN;sp|Q14203|DCTN1_HUMAN;tr|Q6AWB1|Q6AWB1_HUMAN;tr|E7EWF7|E7EWF7_HUMAN;tr|C9JJD0|C9JJD0_HUMAN;tr|C9JUI8|C9JUI8_HUMAN;tr|C9J1B7|C9J1B7_HUMAN;tr|C9JZA4|C9JZA4_HUMAN;tr|C9JTE5|C9JTE5_HUMAN;tr|C9JJN7|C9JJN7_HUMAN;tr|C9JKG6|C9JKG6_HUMAN;tr|E9PCY0|E9PCY0_HUMAN","tr|E7EX90|E7EX90_HUMAN;sp|Q14203|DCTN1_HUMAN;tr|Q6AWB1|Q6AWB1_HUMAN",3088,"E7EX90","E7EX90_HUMAN",null,null,"DCTN1"]
["19.9321","19.4349","20.5455","19.5638",{"$nulls":3},"circadian regulation of gene expression;energy reserve metabolic process;fructose 6-phosphate metabolic process;glutamine metabolic process;IRE1-mediated unfolded protein response;protein N-linked glycosylation;UDP-N-acetylglucosamine biosynthetic process;UDP-N-acetylglucosamine metabolic process","carbohydrate derivative binding;glutamine-fructose-6-phosphate transaminase (isomerizing) activity","cytosol;extracellular exosome","Alanine, aspartate and glutamate metabolism;Amino sugar and nucleotide sugar metabolism;Insulin resistance;Metabolic pathways",null,null,9,9,9,"17.5","17.5","17.5","78.806",0,"59.457",475950000,34,"0.244494","0.784054","-0.371117","-0.674493","sp|Q06210|GFPT1_HUMAN;sp|O94808|GFPT2_HUMAN","sp|Q06210|GFPT1_HUMAN",1457,"Q06210","GFPT1_HUMAN","Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1",null,"GFPT1"]
["17.9103","17.5611","18.6849","17.5289",{"$nulls":4},"ATP binding;protein kinase activity","cytosol",{"$nulls":3},4,4,4,11,11,11,"73.684",0,"11.975",99955000,21,"0.22088","0.801945","-0.371197","-0.614754","tr|E9PPN3|E9PPN3_HUMAN;tr|E9PS17|E9PS17_HUMAN;sp|Q96KG9|NTKL_HUMAN;tr|H0YDH0|H0YDH0_HUMAN;tr|E9PK59|E9PK59_HUMAN;tr|A0A0A0MQX4|A0A0A0MQX4_HUMAN","tr|E9PPN3|E9PPN3_HUMAN;tr|E9PS17|E9PS17_HUMAN;sp|Q96KG9|NTKL_HUMAN;tr|H0YDH0|H0YDH0_HUMAN;tr|E9PK59|E9PK59_HUMAN",2319,"E9PPN3","E9PPN3_HUMAN",null,null,"SCYL1"]
["20.0903","20.4228","20.8564","20.3992",{"$nulls":3},"amyloid-beta metabolic process;neutrophil degranulation;proteolysis;translational termination","identical protein binding;omega peptidase activity;RNA binding;serine-type endopeptidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nuclear membrane",{"$nulls":3},10,10,10,"21.2","21.2","21.2","81.224",0,"33.193",394910000,36,"0.495546","0.517173","-0.371232","-1.31342","sp|P13798|ACPH_HUMAN;tr|C9JIF9|C9JIF9_HUMAN;tr|H7C393|H7C393_HUMAN;tr|H7C1U0|H7C1U0_HUMAN;tr|C9JLK2|C9JLK2_HUMAN;tr|H0YFE5|H0YFE5_HUMAN;tr|F8WEH5|F8WEH5_HUMAN","sp|P13798|ACPH_HUMAN;tr|C9JIF9|C9JIF9_HUMAN;tr|H7C393|H7C393_HUMAN;tr|H7C1U0|H7C1U0_HUMAN",663,"P13798","ACPH_HUMAN","Acylamino-acid-releasing enzyme","ARE","APEH"]
["20.0274","19.8906","20.6786","19.9827",{"$nulls":3},"DNA replication;DNA replication initiation;G1/S transition of mitotic cell cycle","ATP binding;DNA binding;helicase activity","alpha DNA polymerase:primase complex;centrosome;MCM complex;membrane;nuclear chromosome, telomeric region;nucleoplasm;nucleus;perinuclear region of cytoplasm","Cell cycle;DNA replication",null,null,18,18,18,"34.5","34.5","34.5","90.98",0,"141.51",609040000,64,"0.393023","0.626242","-0.371662","-1.04816","sp|P25205|MCM3_HUMAN;tr|J3KQ69|J3KQ69_HUMAN;tr|Q7Z6P5|Q7Z6P5_HUMAN","sp|P25205|MCM3_HUMAN;tr|J3KQ69|J3KQ69_HUMAN",794,"P25205","MCM3_HUMAN","DNA replication licensing factor MCM3",null,"MCM3"]
["16.8979","16.1697","17.6898","16.1229",{"$nulls":3},"protein folding","unfolded protein binding","cytosol;peroxisomal membrane",{"$nulls":3},3,3,3,"17.5","17.5","17.5","33.526",0,"16.361",21038000,4,"0.149744","0.87549","-0.372497","-0.431181","sp|Q99614|TTC1_HUMAN","sp|Q99614|TTC1_HUMAN",2388,"Q99614","TTC1_HUMAN","Tetratricopeptide repeat protein 1","PR repeat protein 1","TTC1"]
["17.577","16.9021","17.6037","17.621",{"$nulls":3},"positive regulation of core promoter binding;positive regulation of viral transcription;regulation of transcription, DNA-templated;RNA polymerase II transcriptional preinitiation complex assembly;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;viral process","core promoter binding;metal ion binding;TBP-class protein binding;thyroid hormone receptor binding;transcription factor binding","nuclear body;nucleoplasm;nucleus;transcription factor TFIID complex;transcriptional preinitiation complex","Basal transcription factors;Viral carcinogenesis",null,null,2,2,2,"7.9","7.9","7.9","34.833","0.00040437","3.449",28787000,4,"0.415052","0.600102","-0.372804","-1.10431","sp|Q00403|TF2B_HUMAN;tr|B1APE1|B1APE1_HUMAN;tr|B1APE2|B1APE2_HUMAN","sp|Q00403|TF2B_HUMAN;tr|B1APE1|B1APE1_HUMAN;tr|B1APE2|B1APE2_HUMAN",1402,"Q00403","TF2B_HUMAN","Transcription initiation factor IIB",null,"GTF2B"]
["18.7676","17.1968","18.8887","17.8215",{"$nulls":4},"methylmalonate-semialdehyde dehydrogenase (acylating) activity","mitochondrion;nucleoplasm",{"$nulls":3},3,3,3,"19.4","19.4","19.4","27.025",0,"18.798",38654000,13,"0.135234","0.89451","-0.372892","-0.39272","tr|G3V4Z4|G3V4Z4_HUMAN;sp|Q02252|MMSA_HUMAN","tr|G3V4Z4|G3V4Z4_HUMAN;sp|Q02252|MMSA_HUMAN",1428,"G3V4Z4","G3V4Z4_HUMAN",null,null,"ALDH6A1"]
["18.9101","19.4161","19.7095","19.3631",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;retrograde vesicle-mediated transport, Golgi to ER;toxin transport","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi membrane;transport vesicle",{"$nulls":3},9,9,9,"13.9","13.9","13.9","102.49",0,"85.6",410410000,22,"0.458934","0.543585","-0.373278","-1.21743","sp|P35606|COPB2_HUMAN;tr|H0YAC7|H0YAC7_HUMAN;tr|H0Y938|H0Y938_HUMAN","sp|P35606|COPB2_HUMAN",934,"P35606","COPB2_HUMAN","Coatomer subunit beta'",null,"COPB2"]
["17.3405","17.3248","17.7699","17.6426",{"$nulls":9},1,1,1,"3.7","3.7","3.7","49.236",0,"29.66",29368000,9,"1.54956","0.326074","-0.373566","-5.82685","tr|A0A096LP26|A0A096LP26_HUMAN;sp|C4AMC7|WASH3_HUMAN;tr|A0A096LP75|A0A096LP75_HUMAN;sp|Q6VEQ5|WASH2_HUMAN;sp|A8K0Z3|WASH1_HUMAN;sp|A8MWX3|WASH4_HUMAN","tr|A0A096LP26|A0A096LP26_HUMAN;sp|C4AMC7|WASH3_HUMAN;tr|A0A096LP75|A0A096LP75_HUMAN;sp|Q6VEQ5|WASH2_HUMAN;sp|A8K0Z3|WASH1_HUMAN;sp|A8MWX3|WASH4_HUMAN",112,"A0A096LP26"]
["19.6484","19.5515","20.4233","19.5239",{"$nulls":5},"nuclear speck",{"$nulls":3},4,4,4,11,11,11,"57.56",0,"12.489",252580000,25,"0.304825","0.724256","-0.37361","-0.826009","tr|G3V1C3|G3V1C3_HUMAN;sp|Q9BZZ5|API5_HUMAN;tr|E9PQK6|E9PQK6_HUMAN","tr|G3V1C3|G3V1C3_HUMAN;sp|Q9BZZ5|API5_HUMAN",2526,"G3V1C3","G3V1C3_HUMAN",null,null,"API5"]
["20.5659","20.7989","21.3116","20.8011",{"$nulls":3},"actin cytoskeleton reorganization;actin filament polymerization;cell motility;dendritic spine maintenance;focal adhesion assembly;intracellular protein transport;lamellipodium organization;membrane organization;negative regulation of extrinsic apoptotic signaling pathway;neuron projection morphogenesis;positive regulation of actin filament polymerization;positive regulation of smooth muscle contraction;receptor-mediated endocytosis;regulation of autophagy of mitochondrion;regulation of axon extension;substrate-dependent cell migration, cell extension","cadherin binding;profilin binding","cell cortex;clathrin-coated pit;cortical cytoskeleton;cytoplasm;cytoskeleton;cytosol;dendritic spine;extracellular exosome;focal adhesion;Golgi apparatus;intracellular membrane-bounded organelle;lamellipodium;mitotic spindle midzone;plasma membrane;podosome;ruffle;voltage-gated potassium channel complex","Bacterial invasion of epithelial cells;Pathogenic Escherichia coli infection;Proteoglycans in cancer;Shigellosis;Tight junction",null,null,9,9,9,24,24,24,"61.585",0,"46.488",511370000,70,"0.502877","0.513548","-0.373981","-1.33284","sp|Q14247|SRC8_HUMAN;tr|H0YEV2|H0YEV2_HUMAN;tr|H0YCD9|H0YCD9_HUMAN","sp|Q14247|SRC8_HUMAN",1615,"Q14247","SRC8_HUMAN","Src substrate cortactin",null,"CTTN"]
["18.935","18.9843","19.2491","19.4189",{"$nulls":4},"oxidoreductase activity",{"$nulls":4},3,3,3,"10.2","10.2","10.2","41.647",0,"15.974",63828000,11,"1.28839","0.331098","-0.37435","-4.23551","tr|C9JMC5|C9JMC5_HUMAN;tr|I3L3I9|I3L3I9_HUMAN;tr|E9PNN6|E9PNN6_HUMAN;sp|P30838|AL3A1_HUMAN;tr|C9JKT2|C9JKT2_HUMAN;tr|A8MYB8|A8MYB8_HUMAN","tr|C9JMC5|C9JMC5_HUMAN;tr|I3L3I9|I3L3I9_HUMAN;tr|E9PNN6|E9PNN6_HUMAN;sp|P30838|AL3A1_HUMAN;tr|C9JKT2|C9JKT2_HUMAN;tr|A8MYB8|A8MYB8_HUMAN",879,"C9JMC5","C9JMC5_HUMAN",null,null,"ALDH3A1"]
["21.5444","20.9654","21.599","21.6601",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;histone exchange;inner ear development;negative regulation of cell differentiation;nucleosome assembly;palate development;positive regulation of protein export from nucleus;vasculature development;ventricular system development","histone binding;RNA polymerase binding","cytoplasm;extracellular exosome;nucleus",{"$nulls":3},5,5,4,"21.1","21.1","21.1","28.787",0,"14.92",225320000,13,"0.485486","0.522862","-0.374596","-1.28688","sp|Q92688|AN32B_HUMAN","sp|Q92688|AN32B_HUMAN",2186,"Q92688","AN32B_HUMAN","Acidic leucine-rich nuclear phosphoprotein 32 family member B",null,"ANP32B"]
["16.6204","16.1091","17.1628","16.3161",{"$nulls":3},"RNA 3'-end processing;RNA polyadenylation","ATP binding;metal ion binding;polynucleotide adenylyltransferase activity;RNA binding","nucleoplasm",{"$nulls":3},2,2,2,"5.2","5.2","5.2","80.625",0,"4.8956",35526000,2,"0.27758","0.753202","-0.374713","-0.757695","tr|G3XAH6|G3XAH6_HUMAN;sp|P51003|PAPOA_HUMAN;tr|G3V457|G3V457_HUMAN;tr|G3V3I9|G3V3I9_HUMAN;tr|A0A0C4DGK1|A0A0C4DGK1_HUMAN","tr|G3XAH6|G3XAH6_HUMAN;sp|P51003|PAPOA_HUMAN;tr|G3V457|G3V457_HUMAN;tr|G3V3I9|G3V3I9_HUMAN;tr|A0A0C4DGK1|A0A0C4DGK1_HUMAN",1127,"G3XAH6","G3XAH6_HUMAN",null,null,"PAPOLA"]
["18.4446","18.2083","19.1997","18.2029",{"$nulls":9},2,2,2,"10.6","10.6","10.6","44.228",0,"20.947",71641000,7,"0.267292","0.7558","-0.374855","-0.731865","tr|B4DIH5|B4DIH5_HUMAN;sp|P61201|CSN2_HUMAN","tr|B4DIH5|B4DIH5_HUMAN;sp|P61201|CSN2_HUMAN",1262,"B4DIH5","B4DIH5_HUMAN",null,null,"COPS2"]
["26.1935","26.2628","26.7579","26.4482",{"$nulls":3},"cellular response to heat;cerebral cortex development;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;hippo signaling;hippocampus development;intracellular signal transduction;MAPK cascade;membrane organization;membrane repolarization during cardiac muscle cell action potential;negative regulation of calcium ion export across plasma membrane;negative regulation of calcium ion transmembrane transporter activity;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of peptidyl-serine dephosphorylation;neuron migration;positive regulation of protein export from nucleus;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein targeting;regulation of cellular response to heat;regulation of cytosolic calcium ion concentration;regulation of G2/M transition of mitotic cell cycle;regulation of heart rate by cardiac conduction;regulation of heart rate by hormone;regulation of membrane repolarization;regulation of potassium ion transmembrane transporter activity;substantia nigra development;viral process","cadherin binding;calcium channel regulator activity;enzyme binding;histone deacetylase binding;identical protein binding;ion channel binding;MHC class II protein complex binding;phosphoprotein binding;phosphoserine residue binding;potassium channel regulator activity;protein domain specific binding;protein heterodimerization activity;Rab guanyl-nucleotide exchange factor activity;RNA binding;ubiquitin protein ligase binding","axon;central region of growth cone;cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;focal adhesion;kinesin complex;melanosome;membrane;mitochondrion;nucleus","Cell cycle;Hepatitis C;Hippo signaling pathway;Neurotrophin signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,19,19,16,71,71,"63.9","29.174",0,"272.28",14204000000,170,"0.848","0.307734","-0.374902","-2.36328","sp|P62258|1433E_HUMAN;tr|B4DJF2|B4DJF2_HUMAN;tr|I3L3T1|I3L3T1_HUMAN;tr|K7EM20|K7EM20_HUMAN;tr|K7EIT4|K7EIT4_HUMAN;tr|I3L0W5|I3L0W5_HUMAN","sp|P62258|1433E_HUMAN",1296,"P62258","1433E_HUMAN","14-3-3 protein epsilon","4-3-3E","YWHAE"]
["18.143",1,"18.8929",1,{"$nulls":3},"ATP metabolic process;cardiac muscle contraction;cell adhesion;cell communication by electrical coupling involved in cardiac conduction;cellular calcium ion homeostasis;cellular potassium ion homeostasis;cellular sodium ion homeostasis;ion transmembrane transport;leukocyte migration;membrane repolarization;membrane repolarization during cardiac muscle cell action potential;positive regulation of ATPase activity;positive regulation of calcium:sodium antiporter activity;positive regulation of potassium ion import;positive regulation of potassium ion transmembrane transporter activity;positive regulation of sodium ion export across plasma membrane;potassium ion import;potassium ion import across plasma membrane;protein localization to plasma membrane;protein stabilization;protein transport into plasma membrane raft;regulation of cardiac conduction;regulation of cardiac muscle contraction by calcium ion signaling;regulation of gene expression;relaxation of cardiac muscle;response to hypoxia;sodium ion export across plasma membrane","ATPase activator activity;ATPase binding;MHC class II protein complex binding;protein C-terminus binding;protein kinase binding;sodium:potassium-exchanging ATPase activity","apical plasma membrane;basolateral plasma membrane;caveola;extracellular exosome;extracellular vesicle;intercalated disc;intracellular;membrane;myelin sheath;plasma membrane;sarcolemma;sodium:potassium-exchanging ATPase complex","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Aldosterone-regulated sodium reabsorption;Bile secretion;cAMP signaling pathway;Carbohydrate digestion and absorption;Cardiac muscle contraction;cGMP-PKG signaling pathway;Endocrine and other factor-regulated calcium reabsorption;Gastric acid secretion;Insulin secretion;Mineral absorption;Pancreatic secretion;Protein digestion and absorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Thyroid hormone signaling pathway;Thyroid hormone synthesis",null,null,2,2,2,"8.3","8.3","8.3","35.061","0.000392","3.2035",51600000,5,"0.00939216","0.983926","-0.374952","-0.0302627","sp|P05026|AT1B1_HUMAN;tr|V9GYR2|V9GYR2_HUMAN","sp|P05026|AT1B1_HUMAN;tr|V9GYR2|V9GYR2_HUMAN",508,"P05026","AT1B1_HUMAN","Sodium/potassium-transporting ATPase subunit beta-1",null,"ATP1B1"]
["20.2419","20.0655","20.8281","20.2296",{"$nulls":5},"extracellular exosome",{"$nulls":3},1,1,1,"6.9","6.9","6.9","18.048",0,"12.99",127270000,9,"0.453217","0.551404","-0.375158","-1.20258","sp|Q9NWV4|CA123_HUMAN","sp|Q9NWV4|CA123_HUMAN",2729,"Q9NWV4","CA123_HUMAN","UPF0587 protein C1orf123",null,"C1orf123"]
["20.7099","20.6787","21.3513","20.7878",{"$nulls":3},"intraciliary transport involved in cilium assembly;NLS-bearing protein import into nucleus;protein import into nucleus, translocation;regulation of mRNA stability;ribosomal protein import into nucleus;viral process","nuclear localization sequence binding;protein transporter activity;Ran GTPase binding;RNA binding","cilium;cytoplasm;cytosol;extracellular exosome;nuclear membrane;nuclear periphery;nucleus",{"$nulls":3},8,8,8,"14.5","14.5","14.5","102.35",0,"150.12",683480000,35,"0.501784","0.513219","-0.375302","-1.32994","sp|Q92973|TNPO1_HUMAN;tr|S4R398|S4R398_HUMAN;tr|E7EW37|E7EW37_HUMAN","sp|Q92973|TNPO1_HUMAN",2208,"Q92973","TNPO1_HUMAN","Transportin-1",null,"TNPO1"]
["20.2836","19.7648","20.3956","20.404",{"$nulls":3},"immune response;inosine catabolic process;interleukin-2 secretion;NAD biosynthesis via nicotinamide riboside salvage pathway;neutrophil degranulation;nicotinamide riboside catabolic process;nucleobase-containing compound metabolic process;positive regulation of alpha-beta T cell differentiation;positive regulation of T cell proliferation;purine nucleotide catabolic process;purine-containing compound salvage;response to drug;urate biosynthetic process","drug binding;nucleoside binding;phosphate ion binding;purine nucleobase binding;purine-nucleoside phosphorylase activity","cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular;nucleus;secretory granule lumen","Metabolic pathways;Nicotinate and nicotinamide metabolism;Purine metabolism;Pyrimidine metabolism",null,null,6,6,6,"34.3","34.3","34.3","32.118",0,"29.931",264260000,26,"0.545564","0.485088","-0.375568","-1.44744","sp|P00491|PNPH_HUMAN;tr|G3V5M2|G3V5M2_HUMAN;tr|G3V2H3|G3V2H3_HUMAN;tr|G3V393|G3V393_HUMAN","sp|P00491|PNPH_HUMAN;tr|G3V5M2|G3V5M2_HUMAN",469,"P00491","PNPH_HUMAN","Purine nucleoside phosphorylase","NP","PNP"]
["19.2711","19.3606","20.0616","19.322",{"$nulls":9},7,7,7,18,18,18,"70.443",0,"32.6",227780000,30,"0.377661","0.645128","-0.375934","-1.00921","tr|Q5JPT2|Q5JPT2_HUMAN;sp|Q96B97|SH3K1_HUMAN;tr|Q5VSN0|Q5VSN0_HUMAN;tr|Q5JPT3|Q5JPT3_HUMAN;tr|Q5JPT1|Q5JPT1_HUMAN","tr|Q5JPT2|Q5JPT2_HUMAN;sp|Q96B97|SH3K1_HUMAN",2237,"Q5JPT2","Q5JPT2_HUMAN",null,null,"SH3KBP1"]
["27.5876","27.4111","28.0807","27.6734",{"$nulls":3},"actin cytoskeleton organization;negative regulation of actin filament bundle assembly;negative regulation of actin filament polymerization;negative regulation of stress fiber assembly;neural tube closure;positive regulation of actin filament bundle assembly;positive regulation of actin filament polymerization;positive regulation of ATPase activity;positive regulation of epithelial cell migration;positive regulation of ruffle assembly;protein stabilization;regulation of transcription from RNA polymerase II promoter;Wnt signaling pathway, planar cell polarity pathway","actin binding;actin monomer binding;adenyl-nucleotide exchange factor activity;cadherin binding;phosphatidylinositol-4,5-bisphosphate binding;proline-rich region binding;Rho GTPase binding;RNA binding","blood microparticle;cell cortex;cytoplasm;cytoskeleton;cytosol;extracellular exosome;focal adhesion;membrane;nucleus","Rap1 signaling pathway;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,10,10,10,"88.6","88.6","88.6","15.054",0,"323.31",18984000000,170,"0.636608","0.407769","-0.377678","-1.7019","sp|P07737|PROF1_HUMAN;tr|K7EJ44|K7EJ44_HUMAN;CON__P02584;tr|I3L3D5|I3L3D5_HUMAN","sp|P07737|PROF1_HUMAN;tr|K7EJ44|K7EJ44_HUMAN",546,"P07737","PROF1_HUMAN","Profilin-1",null,"PFN1"]
["20.0231","20.2207","20.3312","20.6682",{"$nulls":3},"cell growth involved in cardiac muscle cell development;regulation of dendritic spine morphogenesis;regulation of synapse assembly","actin binding;actinin binding;cadherin binding involved in cell-cell adhesion;metal ion binding;protein kinase C binding;protein N-terminus binding","actin cytoskeleton;cell-cell adherens junction;cytosol;membrane;neuron projection;postsynaptic density;postsynaptic membrane",{"$nulls":3},7,7,7,18,18,18,"63.944",0,"39.977",484440000,43,"0.715042","0.359826","-0.377827","-1.93438","sp|Q96HC4|PDLI5_HUMAN;tr|A0A0D9SFR4|A0A0D9SFR4_HUMAN;tr|H0Y929|H0Y929_HUMAN;tr|H0YBI4|H0YBI4_HUMAN;tr|H0Y8Y3|H0Y8Y3_HUMAN;tr|A0A0A0MSP3|A0A0A0MSP3_HUMAN","sp|Q96HC4|PDLI5_HUMAN;tr|A0A0D9SFR4|A0A0D9SFR4_HUMAN",2287,"Q96HC4","PDLI5_HUMAN","PDZ and LIM domain protein 5",null,"PDLIM5"]
["16.9957","17.2903","18.4841","16.5578",{"$nulls":3},"tRNA processing",null,"mitochondrion;nucleoplasm",{"$nulls":3},3,3,3,"14.1","14.1","14.1","36.828",0,"9.7749",31903000,5,"0.133418","0.896275","-0.377929","-0.387876","tr|C9JVB6|C9JVB6_HUMAN;sp|Q7L0Y3|MRRP1_HUMAN","tr|C9JVB6|C9JVB6_HUMAN;sp|Q7L0Y3|MRRP1_HUMAN",1929,"C9JVB6","C9JVB6_HUMAN",null,null,"TRMT10C"]
["15.8785","15.9751","16.159","16.4513",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;intracellular protein transport;intra-Golgi vesicle-mediated transport;protein glycosylation;protein localization to organelle;protein stabilization;retrograde vesicle-mediated transport, Golgi to ER","protein transporter activity","cis-Golgi network;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;Golgi transport complex;trans-Golgi network membrane",{"$nulls":3},1,1,1,"1.4","1.4","1.4","94.095",0,"13.411",35387000,8,"0.875237","0.304057","-0.37835","-2.45738","sp|Q96JB2|COG3_HUMAN","sp|Q96JB2|COG3_HUMAN",2303,"Q96JB2","COG3_HUMAN","Conserved oligomeric Golgi complex subunit 3","OG complex subunit 3","COG3"]
["22.1969","22.0549","22.8609","22.1477",{"$nulls":3},"actin polymerization or depolymerization;activation of adenylate cyclase activity;ameboidal-type cell migration;cell morphogenesis;establishment or maintenance of cell polarity;neutrophil degranulation;receptor-mediated endocytosis;signal transduction","actin binding;adenylate cyclase binding","azurophil granule lumen;cortical actin cytoskeleton;extracellular exosome;extracellular region;focal adhesion;plasma membrane",{"$nulls":3},15,15,15,"40.2","40.2","40.2","51.901",0,"154.84",1440900000,86,"0.390129","0.633177","-0.378439","-1.04081","sp|Q01518|CAP1_HUMAN;tr|Q5T0R1|Q5T0R1_HUMAN;tr|Q5T0R7|Q5T0R7_HUMAN;tr|Q5T0R6|Q5T0R6_HUMAN;tr|Q5T0R5|Q5T0R5_HUMAN;tr|Q5T0R4|Q5T0R4_HUMAN;tr|Q5T0R3|Q5T0R3_HUMAN;tr|Q5T0R2|Q5T0R2_HUMAN;tr|Q5T0R9|Q5T0R9_HUMAN;tr|Q5T0S3|Q5T0S3_HUMAN;tr|Q5T0R8|Q5T0R8_HUMAN;tr|B7Z385|B7Z385_HUMAN;tr|A0A087X0J3|A0A087X0J3_HUMAN;tr|A0A087WZ15|A0A087WZ15_HUMAN;tr|E9PDI2|E9PDI2_HUMAN;sp|P40123|CAP2_HUMAN","sp|Q01518|CAP1_HUMAN",1416,"Q01518","CAP1_HUMAN","Adenylyl cyclase-associated protein 1","AP 1","CAP1"]
["19.3402","18.7463","19.844","18.9994",{"$nulls":3},"calcium ion homeostasis;endoplasmic reticulum organization;ER overload response;osteoblast differentiation;post-embryonic development;ubiquitin-dependent ERAD pathway","calcium ion binding;RNA binding","endoplasmic reticulum;integral component of membrane;membrane;rough endoplasmic reticulum",{"$nulls":3},6,6,6,"18.4","18.4","18.4","55.873",0,"19.07",128100000,25,"0.267773","0.755828","-0.378465","-0.733074","sp|Q96A33|CCD47_HUMAN;tr|A0A087WYW6|A0A087WYW6_HUMAN;tr|J3QR89|J3QR89_HUMAN","sp|Q96A33|CCD47_HUMAN;tr|A0A087WYW6|A0A087WYW6_HUMAN",2227,"Q96A33","CCD47_HUMAN","Coiled-coil domain-containing protein 47",null,"CCDC47"]
["17.53","17.1638","17.6636","17.7878",{"$nulls":3},"spliceosomal tri-snRNP complex assembly",null,"nucleus;U4/U6 x U5 tri-snRNP complex",{"$nulls":3},1,1,1,"5.8","5.8","5.8","28.858","0.0003882","3.1071",17970000,6,"0.723097","0.353892","-0.3788","-1.95905","tr|E7EU94|E7EU94_HUMAN;tr|E7ESX0|E7ESX0_HUMAN;tr|E7EN72|E7EN72_HUMAN;tr|E7EVX8|E7EVX8_HUMAN;sp|Q8WWY3|PRP31_HUMAN","tr|E7EU94|E7EU94_HUMAN;tr|E7ESX0|E7ESX0_HUMAN;tr|E7EN72|E7EN72_HUMAN;tr|E7EVX8|E7EVX8_HUMAN;sp|Q8WWY3|PRP31_HUMAN",2153,"E7EU94","E7EU94_HUMAN",null,null,"PRPF31"]
["23.1395","22.9521","23.4878","23.364",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;response to virus;toxin transport","ATP binding;beta-tubulin binding;G-protein beta-subunit binding;mRNA 3'-UTR binding;mRNA 5'-UTR binding;protein binding involved in protein folding;unfolded protein binding","cell body;centrosome;chaperonin-containing T-complex;cytosol;extracellular exosome;microtubule;myelin sheath;nucleolus;zona pellucida receptor complex",{"$nulls":3},19,19,19,"52.9","52.9","52.9","59.67",0,"323.31",3083900000,114,"1.11161","0.311256","-0.380068","-3.38385","sp|P48643|TCPE_HUMAN;tr|B7ZAR1|B7ZAR1_HUMAN;tr|E9PCA1|E9PCA1_HUMAN;tr|E7ENZ3|E7ENZ3_HUMAN;tr|D6RIZ7|D6RIZ7_HUMAN","sp|P48643|TCPE_HUMAN;tr|B7ZAR1|B7ZAR1_HUMAN;tr|E9PCA1|E9PCA1_HUMAN;tr|E7ENZ3|E7ENZ3_HUMAN",1058,"P48643","TCPE_HUMAN","T-complex protein 1 subunit epsilon","CP-1-epsilon","CCT5"]
[1,"15.7913","16.5528",1,{"$nulls":9},1,1,1,"14.8","14.8","14.8","22.588","0.0037762","2.0689",9850500,4,"0.0110305","0.982876","-0.380737","-0.035478","tr|H3BQC4|H3BQC4_HUMAN;sp|O43294|TGFI1_HUMAN","tr|H3BQC4|H3BQC4_HUMAN;sp|O43294|TGFI1_HUMAN",241,"H3BQC4","H3BQC4_HUMAN",null,null,"TGFB1I1"]
["22.685","22.8662","23.2585","23.0552",{"$nulls":3},"cellular protein modification process;NIK/NF-kappaB signaling;positive regulation of neuron apoptotic process;post-translational protein modification;protein neddylation;transforming growth factor beta receptor signaling pathway","ATP binding;NEDD8 transferase activity;ribosomal S6-glutamic acid ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm","Ubiquitin mediated proteolysis",null,null,6,6,6,"35.5","35.5","35.5","20.9",0,"37.304",805360000,30,"0.968775","0.297061","-0.381236","-2.79904","sp|P61081|UBC12_HUMAN;tr|M0QX69|M0QX69_HUMAN;tr|M0QYI6|M0QYI6_HUMAN","sp|P61081|UBC12_HUMAN",1255,"P61081","UBC12_HUMAN","NEDD8-conjugating enzyme Ubc12",null,"UBE2M"]
["18.7283","18.4505","19.3979","18.5465",{"$nulls":9},1,1,1,8,8,8,"19.291","0.001408","2.3125",42192000,4,"0.316309","0.713711","-0.382766","-0.854802","sp|Q9GZN8|CT027_HUMAN","sp|Q9GZN8|CT027_HUMAN",2536,"Q9GZN8","CT027_HUMAN","UPF0687 protein C20orf27",null,"C20orf27"]
["26.6851","26.5598","27.2403","26.771",{"$nulls":3},"cell division;cellular response to interleukin-4;cytoskeleton-dependent intracellular transport;microtubule cytoskeleton organization;microtubule-based process","double-stranded RNA binding;GTP binding;GTPase activity;structural constituent of cytoskeleton;structural molecule activity;ubiquitin protein ligase binding","cytoplasmic microtubule;extracellular exosome;membrane raft;microtubule;microtubule cytoskeleton;myelin sheath","Apoptosis;Gap junction;Pathogenic Escherichia coli infection;Phagosome;Tight junction",null,null,21,21,0,"58.3","58.3",0,"50.151",0,"323.31",28602000000,365,"0.592915","0.444076","-0.383195","-1.57792","sp|P68363|TBA1B_HUMAN","sp|P68363|TBA1B_HUMAN",1358,"P68363","TBA1B_HUMAN","Tubulin alpha-1B chain",null,"TUBA1B"]
["21.5073","21.4307","22.0905","21.6145",{"$nulls":3},"proteolysis","dipeptidyl-peptidase activity;metallopeptidase activity;zinc ion binding","cytoplasm;cytosol;extracellular exosome;nuclear speck;plasma membrane",{"$nulls":3},14,14,14,"27.7","27.7","27.7","82.588",0,"323.31",1358600000,99,"0.597641","0.439143","-0.383498","-1.59115","sp|Q9NY33|DPP3_HUMAN;tr|G3V1D3|G3V1D3_HUMAN;tr|G3V180|G3V180_HUMAN;tr|E9PQ14|E9PQ14_HUMAN;tr|E9PKK8|E9PKK8_HUMAN;tr|E9PPK9|E9PPK9_HUMAN;tr|E9PNX5|E9PNX5_HUMAN;tr|E9PQF2|E9PQF2_HUMAN","sp|Q9NY33|DPP3_HUMAN;tr|G3V1D3|G3V1D3_HUMAN;tr|G3V180|G3V180_HUMAN",2746,"Q9NY33","DPP3_HUMAN","Dipeptidyl peptidase 3",null,"DPP3"]
["26.6786","27.1633","27.332","27.2775",{"$nulls":3},"anatomical structure morphogenesis;cell cycle;cornification;extrinsic apoptotic signaling pathway;Golgi to plasma membrane CFTR protein transport;hepatocyte apoptotic process;intermediate filament cytoskeleton organization;keratinization;negative regulation of apoptotic process;tumor necrosis factor-mediated signaling pathway;viral process","cadherin binding involved in cell-cell adhesion;RNA binding;scaffold protein binding;structural molecule activity","cell periphery;cell-cell adherens junction;centriolar satellite;cytoplasm;cytosol;extracellular exosome;intermediate filament;keratin filament;microtubule organizing center;nucleolus;perinuclear region of cytoplasm","Estrogen signaling pathway;Pathogenic Escherichia coli infection",null,null,32,32,21,"77.4","77.4","57.4","48.057",0,"323.31",40148000000,525,"0.591441","0.446056","-0.383831","-1.5738","sp|P05783|K1C18_HUMAN;tr|F8VZY9|F8VZY9_HUMAN;CON__H-INV:HIT000015463;tr|C4AM86|C4AM86_HUMAN;CON__Q92764;sp|Q92764|KRT35_HUMAN","sp|P05783|K1C18_HUMAN;tr|F8VZY9|F8VZY9_HUMAN",524,"P05783","K1C18_HUMAN","Keratin, type I cytoskeletal 18",null,"KRT18"]
["18.1629","18.0251","18.6433","18.3125",{"$nulls":9},12,12,12,"6.8","6.8","6.8","286.97",0,"68.619",356930000,53,"0.781455","0.334595","-0.383921","-2.14264","tr|E9PEM5|E9PEM5_HUMAN;sp|P50851|LRBA_HUMAN;tr|H0YAC6|H0YAC6_HUMAN","tr|E9PEM5|E9PEM5_HUMAN;sp|P50851|LRBA_HUMAN",3089,"E9PEM5","E9PEM5_HUMAN",null,null,"LRBA"]
["19.7269","19.5232","20.1513","19.8674",{"$nulls":3},"cilium assembly;nervous system development;neuron projection development;protein homotrimerization","enzyme binding;identical protein binding","cytoplasm;cytosol;dendrite;extracellular space;membrane;neuronal cell body;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},5,5,5,"14.9","14.9","14.9","53.488",0,"12.026",263720000,15,"0.798944","0.33037","-0.384244","-2.19941","sp|Q9UBB4|ATX10_HUMAN;tr|B1AHE3|B1AHE3_HUMAN;tr|B1AHE4|B1AHE4_HUMAN","sp|Q9UBB4|ATX10_HUMAN",2796,"Q9UBB4","ATX10_HUMAN","Ataxin-10",null,"ATXN10"]
["19.1564","18.9851","19.6684","19.2424",{"$nulls":9},1,1,1,"13.1","13.1","13.1","11.6","0.0010929","2.5447",23892000,4,"0.627333","0.417399","-0.384638","-1.67527","tr|E9PLD3|E9PLD3_HUMAN;sp|E9PRG8|CK098_HUMAN;tr|A0A0B4J220|A0A0B4J220_HUMAN","tr|E9PLD3|E9PLD3_HUMAN;sp|E9PRG8|CK098_HUMAN;tr|A0A0B4J220|A0A0B4J220_HUMAN",115,"E9PLD3","E9PLD3_HUMAN"]
["19.9959","19.7461","20.58","19.9315",{"$nulls":3},"mRNA transport;protein transport;regulation of gene expression;RNA secondary structure unwinding;RNA splicing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","catalytic step 2 spliceosome;cytoplasm;membrane;nuclear membrane;nuclear pore;nucleolus",{"$nulls":3},7,7,2,"17.8","17.8","8.4","53.974",0,"29.438",319040000,33,"0.416207","0.599774","-0.384778","-1.10726","sp|Q9NUU7|DD19A_HUMAN;tr|I3L0H8|I3L0H8_HUMAN;tr|F6QDS0|F6QDS0_HUMAN;tr|H3BTB3|H3BTB3_HUMAN;tr|I3L352|I3L352_HUMAN;tr|J3QRH0|J3QRH0_HUMAN;tr|H3BSL8|H3BSL8_HUMAN","sp|Q9NUU7|DD19A_HUMAN;tr|I3L0H8|I3L0H8_HUMAN;tr|F6QDS0|F6QDS0_HUMAN;tr|H3BTB3|H3BTB3_HUMAN",2712,"Q9NUU7","DD19A_HUMAN","ATP-dependent RNA helicase DDX19A",null,"DDX19A"]
["18.134","18.061","18.9662","17.9985",{"$nulls":3},"cellular nitrogen compound metabolic process;glycine catabolic process;glycine decarboxylation via glycine cleavage system;protein lipoylation","aminomethyltransferase activity","glycine cleavage complex;mitochondrial matrix;mitochondrion","Carbon metabolism;Glycine, serine and threonine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways",null,null,1,1,1,"11.6","11.6","11.6","18.884",0,"21.746",24044000,9,"0.291712","0.739677","-0.384831","-0.793137","sp|P23434|GCSH_HUMAN","sp|P23434|GCSH_HUMAN",779,"P23434","GCSH_HUMAN","Glycine cleavage system H protein, mitochondrial {ECO:0000303|PubMed:1671321}",null,"GCSH"]
["18.0297","16.8336","17.8175","17.8155",{"$nulls":3},"microtubule-based process",null,"dynactin complex",{"$nulls":3},2,2,2,"9.7","9.7","9.7","29.326",0,"3.9339",22365000,5,"0.232272","0.792611","-0.384922","-0.643623","tr|H0YI98|H0YI98_HUMAN;sp|Q13561|DCTN2_HUMAN;tr|F8VX93|F8VX93_HUMAN;tr|F8VW18|F8VW18_HUMAN;tr|F8W1I6|F8W1I6_HUMAN","tr|H0YI98|H0YI98_HUMAN;sp|Q13561|DCTN2_HUMAN;tr|F8VX93|F8VX93_HUMAN;tr|F8VW18|F8VW18_HUMAN;tr|F8W1I6|F8W1I6_HUMAN",1571,"H0YI98","H0YI98_HUMAN",null,null,"DCTN2"]
["19.108","20.2285","19.6608","20.4457",{"$nulls":3},"cellular response to osmotic stress;negative regulation of endopeptidase activity;neutrophil degranulation;sensory perception of sound","protease binding;serine-type endopeptidase inhibitor activity","cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule membrane;plasma membrane;protein complex;secretory granule membrane;tertiary granule membrane","Amoebiasis",null,null,5,5,5,17,17,17,"42.621",0,"26.579",198590000,13,"0.200513","0.821943","-0.384992","-0.562855","sp|P35237|SPB6_HUMAN;tr|A0A024QZX5|A0A024QZX5_HUMAN;tr|A0A087X1N8|A0A087X1N8_HUMAN;tr|C9JTJ8|C9JTJ8_HUMAN;tr|C9JVA8|C9JVA8_HUMAN;tr|H7BXK7|H7BXK7_HUMAN;sp|P50452|SPB8_HUMAN","sp|P35237|SPB6_HUMAN;tr|A0A024QZX5|A0A024QZX5_HUMAN;tr|A0A087X1N8|A0A087X1N8_HUMAN",923,"P35237","SPB6_HUMAN","Serpin B6",null,"SERPINB6"]
["20.4376","20.3395","21.0407","20.5066",{"$nulls":3},"mRNA splicing, via spliceosome;protein folding","disordered domain specific binding;peptidyl-prolyl cis-trans isomerase activity","catalytic step 2 spliceosome;extracellular exosome;nucleoplasm","Spliceosome",null,null,2,2,2,"18.7","18.7","18.7","18.237",0,"4.9566",111160000,7,"0.534832","0.493126","-0.385085","-1.41837","sp|Q9Y3C6|PPIL1_HUMAN","sp|Q9Y3C6|PPIL1_HUMAN",2983,"Q9Y3C6","PPIL1_HUMAN","Peptidyl-prolyl cis-trans isomerase-like 1","PIase","PPIL1"]
["22.4349","22.2434","23.0441","22.4051",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;toxin transport","ATP binding;identical protein binding;protein binding involved in protein folding;unfolded protein binding","cell body;chaperonin-containing T-complex;cytoplasm;cytosol;extracellular exosome;microtubule;mitochondrion;zona pellucida receptor complex",{"$nulls":3},21,21,21,"47.3","47.3","47.3","59.366",0,"193.7",1951500000,83,"0.435108","0.575013","-0.385486","-1.15578","sp|Q99832|TCPH_HUMAN;tr|F8WAM2|F8WAM2_HUMAN","sp|Q99832|TCPH_HUMAN",2400,"Q99832","TCPH_HUMAN","T-complex protein 1 subunit eta","CP-1-eta","CCT7"]
["24.5011","24.7209","25.0524","24.9412",{"$nulls":3},"actin filament bundle assembly;bicellular tight junction assembly;negative regulation of cellular component movement;negative regulation of substrate adhesion-dependent cell spreading;peroxisome proliferator activated receptor signaling pathway;platelet degranulation;positive regulation of cell migration;positive regulation of cellular component movement;positive regulation of NIK/NF-kappaB signaling;positive regulation of pinocytosis;positive regulation of sodium:proton antiporter activity;protein localization to bicellular tight junction;protein transport;regulation of apoptotic process;regulation of nucleic acid-templated transcription;response to hypoxia;retinoic acid receptor signaling pathway;vesicle transport along actin filament","actin binding;actin filament binding;calcium ion binding;chromatin DNA binding;integrin binding;ion channel binding;ligand-dependent nuclear receptor transcription coactivator activity;nuclear hormone receptor binding;nucleoside binding;protein homodimerization activity;protein N-terminus binding;retinoic acid receptor binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding","brush border;cell-cell junction;cortical cytoskeleton;cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;focal adhesion;intracellular;intracellular ribonucleoprotein complex;neuron projection;nuclear body;nucleus;perinuclear region of cytoplasm;platelet alpha granule lumen;protein complex;pseudopodium;stress fiber;Z disc","Adherens junction;Amoebiasis;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Systemic lupus erythematosus;Tight junction;Viral carcinogenesis",null,null,40,40,28,"57.3","57.3","41.4","104.85",0,"323.31",12710000000,361,"1.05262","0.304542","-0.385798","-3.13231","sp|O43707|ACTN4_HUMAN;tr|F5GXS2|F5GXS2_HUMAN;tr|H7C144|H7C144_HUMAN;tr|K7EJH8|K7EJH8_HUMAN;tr|K7EP19|K7EP19_HUMAN","sp|O43707|ACTN4_HUMAN;tr|F5GXS2|F5GXS2_HUMAN",259,"O43707","ACTN4_HUMAN","Alpha-actinin-4 {ECO:0000305}",null,"ACTN4"]
["18.5639","18.4546","18.9906","18.8002",{"$nulls":3},"actin filament capping;actin filament depolymerization;actin filament polymerization;actin filament severing;actin nucleation;barbed-end actin filament capping;cellular response to epidermal growth factor stimulus;cellular response to hepatocyte growth factor stimulus;cytoplasmic actin-based contraction involved in cell motility;epidermal growth factor receptor signaling pathway;epithelial cell differentiation;intestinal D-glucose absorption;positive regulation of actin filament bundle assembly;positive regulation of actin filament depolymerization;positive regulation of cell migration;positive regulation of epithelial cell migration;positive regulation of lamellipodium morphogenesis;positive regulation of multicellular organism growth;positive regulation of protein localization to plasma membrane;protein complex assembly;regulation of actin nucleation;regulation of cell shape;regulation of lamellipodium morphogenesis;regulation of microvillus length;regulation of wound healing;response to bacterium;terminal web assembly","actin filament binding;calcium ion binding;cysteine-type endopeptidase inhibitor activity involved in apoptotic process;identical protein binding;lysophosphatidic acid binding;phosphatidylinositol-4,5-bisphosphate binding;protein homodimerization activity","actin filament bundle;brush border;cytoplasm;extracellular exosome;filopodium;filopodium tip;lamellipodium;microvillus;nucleoplasm;plasma membrane;ruffle",{"$nulls":3},5,5,5,"7.5","7.5","7.5","92.694",0,"24.768",156210000,17,"1.1417","0.313947","-0.386106","-3.51806","sp|P09327|VILI_HUMAN;tr|C9J2B5|C9J2B5_HUMAN;tr|B4DV78|B4DV78_HUMAN;tr|H7C0B6|H7C0B6_HUMAN","sp|P09327|VILI_HUMAN",580,"P09327","VILI_HUMAN","Villin-1",null,"VIL1"]
["21.6191","21.756","22.2918","21.8557",{"$nulls":3},"positive regulation of protein targeting to mitochondrion;protein sumoylation;protein ubiquitination","ATP-dependent protein binding;enzyme activator activity;protein C-terminus binding;protein heterodimerization activity;small protein activating enzyme binding;ubiquitin activating enzyme activity","cytoplasm;nucleoplasm;nucleus;SUMO activating enzyme complex","Ubiquitin mediated proteolysis",null,null,7,7,7,"22.8","22.8","22.8","38.449",0,"104.85",725600000,56,"0.632465","0.410112","-0.38624","-1.68998","sp|Q9UBE0|SAE1_HUMAN;tr|B3KNJ4|B3KNJ4_HUMAN;tr|M0QX65|M0QX65_HUMAN;tr|M0QZS6|M0QZS6_HUMAN;tr|M0R054|M0R054_HUMAN;tr|M0R286|M0R286_HUMAN;tr|M0QYM8|M0QYM8_HUMAN;tr|M0R375|M0R375_HUMAN;tr|M0QYP2|M0QYP2_HUMAN","sp|Q9UBE0|SAE1_HUMAN;tr|B3KNJ4|B3KNJ4_HUMAN;tr|M0QX65|M0QX65_HUMAN;tr|M0QZS6|M0QZS6_HUMAN;tr|M0R054|M0R054_HUMAN",2799,"Q9UBE0","SAE1_HUMAN","SUMO-activating enzyme subunit 1",null,"SAE1"]
["18.016","17.8504","18.7808","17.8584",{"$nulls":3},"chromatin remodeling",null,"fibrillar center;intracellular membrane-bounded organelle;nuclear chromosome;nucleoplasm",{"$nulls":3},2,2,2,"11.9","11.9","11.9","25.917","0.0011173","2.7682",34446000,3,"0.304311","0.724258","-0.386414","-0.824721","tr|C9JTA6|C9JTA6_HUMAN;tr|A0A0G2JSE9|A0A0G2JSE9_HUMAN;sp|Q12824|SNF5_HUMAN;tr|G5E975|G5E975_HUMAN;tr|B5MCL5|B5MCL5_HUMAN","tr|C9JTA6|C9JTA6_HUMAN;tr|A0A0G2JSE9|A0A0G2JSE9_HUMAN;sp|Q12824|SNF5_HUMAN;tr|G5E975|G5E975_HUMAN;tr|B5MCL5|B5MCL5_HUMAN",1497,"C9JTA6","C9JTA6_HUMAN",null,null,"SMARCB1"]
["18.7434","18.6646","19.2271","18.9537",{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of gene expression, epigenetic;RNA splicing, via transesterification reactions;spliceosomal complex assembly","mRNA binding;RNA binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;nucleus;spliceosomal complex;U11/U12 snRNP;U12-type spliceosomal complex;U2 snRNP;U2-type prespliceosome","Spliceosome",null,null,10,10,10,"13.3","13.3","13.3","145.83",0,"48.848",317370000,38,"0.946779","0.295157","-0.386429","-2.71599","sp|O75533|SF3B1_HUMAN;tr|B4DGZ4|B4DGZ4_HUMAN","sp|O75533|SF3B1_HUMAN",351,"O75533","SF3B1_HUMAN","Splicing factor 3B subunit 1",null,"SF3B1"]
["22.6047","22.6256","23.1001","22.9036",{"$nulls":9},1,1,1,"14.1","14.1","14.1","7.0662","0.0010665","2.3726",187120000,7,"1.22527","0.317064","-0.386741","-3.91329","sp|Q9Y2S6|TMA7_HUMAN","sp|Q9Y2S6|TMA7_HUMAN",2955,"Q9Y2S6","TMA7_HUMAN","Translation machinery-associated protein 7",null,"TMA7"]
["19.0623","19.094","19.9116","19.0185",{"$nulls":3},"carbohydrate metabolic process;malate metabolic process;NADP biosynthetic process;protein tetramerization;pyruvate metabolic process;regulation of lipid metabolic process;regulation of NADP metabolic process;response to carbohydrate;response to hormone","ADP binding;electron transfer activity;malate dehydrogenase (decarboxylating) (NAD+) activity;malate dehydrogenase (decarboxylating) (NADP+) activity;malic enzyme activity;manganese ion binding;NAD binding;NADP binding;oxaloacetate decarboxylase activity","cytosol;mitochondrion","Carbon metabolism;Metabolic pathways;PPAR signaling pathway;Pyruvate metabolism",null,null,2,2,2,"3.5","3.5","3.5","64.149",0,"14.899",166860000,9,"0.320702","0.709882","-0.386879","-0.86582","sp|P48163|MAOX_HUMAN","sp|P48163|MAOX_HUMAN",1051,"P48163","MAOX_HUMAN","NADP-dependent malic enzyme","ADP-ME","ME1"]
["19.0394","19.3578","19.7431","19.4283",{"$nulls":4},"actin binding",{"$nulls":4},1,1,1,"15.5","15.5","15.5","10.661","0.00039231","3.2037",36865000,9,"0.646189","0.401275","-0.387115","-1.72958","tr|J3QKM5|J3QKM5_HUMAN;sp|Q8TF74|WIPF2_HUMAN","tr|J3QKM5|J3QKM5_HUMAN;sp|Q8TF74|WIPF2_HUMAN",2133,"J3QKM5","J3QKM5_HUMAN",null,null,"WIPF2"]
["23.2241","23.2874","23.6924","23.5971",{"$nulls":3},"cell cycle arrest;cell proliferation;cell surface receptor signaling pathway;G2/M transition of mitotic cell cycle;mRNA processing;negative regulation of transcription, DNA-templated;positive regulation of RNA export from nucleus;positive regulation of translational initiation;protein oligomerization;regulation of mRNA splicing, via spliceosome;regulation of RNA export from nucleus;signal transduction;spermatogenesis;transcription, DNA-templated","DNA binding;identical protein binding;poly(A) binding;poly(U) RNA binding;protein complex binding;protein domain specific binding;RNA binding;SH3 domain binding;SH3/SH2 adaptor activity","cytosol;Grb2-Sos complex;membrane;nucleoplasm;nucleus",{"$nulls":3},4,4,4,19,19,19,"48.227",0,"25.545",957870000,44,"1.67834","0.341595","-0.388994","-6.79602","sp|Q07666|KHDR1_HUMAN","sp|Q07666|KHDR1_HUMAN",1466,"Q07666","KHDR1_HUMAN","KH domain-containing, RNA-binding, signal transduction-associated protein 1",null,"KHDRBS1"]
["22.6666","21.7104","22.7539","22.4027",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosome biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;mitochondrion","Ribosome",null,null,3,3,3,"13.7","13.7","13.7","13.293",0,"4.3246",398810000,7,"0.280616","0.749176","-0.389806","-0.765312","sp|P49207|RL34_HUMAN","sp|P49207|RL34_HUMAN",1068,"P49207","RL34_HUMAN","60S ribosomal protein L34",null,"RPL34"]
["24.1981","24.2122","24.7022","24.4878",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},2,2,2,"17.7","17.7","17.7","10.645",0,"3.6526",1025600000,11,"1.16548","0.315","-0.389817","-3.62705","tr|F2Z388|F2Z388_HUMAN;sp|P42766|RL35_HUMAN","tr|F2Z388|F2Z388_HUMAN;sp|P42766|RL35_HUMAN",999,"F2Z388","F2Z388_HUMAN",null,null,"RPL35"]
["15.5716",1,"16.3514",1,{"$nulls":3},"RNA processing","RNA binding","nucleus",{"$nulls":3},2,2,2,"8.6","8.6","8.6","43.958",0,"3.9228",13114000,2,"0.0114595","0.982762","-0.389885","-0.0368407","sp|Q15434|RBMS2_HUMAN;tr|F5H5C8|F5H5C8_HUMAN;tr|F8VV01|F8VV01_HUMAN;tr|F8W1T6|F8W1T6_HUMAN","sp|Q15434|RBMS2_HUMAN;tr|F5H5C8|F5H5C8_HUMAN;tr|F8VV01|F8VV01_HUMAN;tr|F8W1T6|F8W1T6_HUMAN",1702,"Q15434","RBMS2_HUMAN","RNA-binding motif, single-stranded-interacting protein 2",null,"RBMS2"]
["18.8445","18.5109","19.4483","18.6876",{"$nulls":3},"biosynthetic process","catalytic activity",{"$nulls":4},2,2,2,"14.5","14.5","14.5","23.221",0,"5.2774",64947000,9,"0.350105","0.685597","-0.390257","-0.939681","tr|I3L3V9|I3L3V9_HUMAN;tr|I3L1R7|I3L1R7_HUMAN;sp|Q99447|PCY2_HUMAN;tr|I3L1L9|I3L1L9_HUMAN","tr|I3L3V9|I3L3V9_HUMAN;tr|I3L1R7|I3L1R7_HUMAN;sp|Q99447|PCY2_HUMAN;tr|I3L1L9|I3L1L9_HUMAN",2371,"I3L3V9","I3L3V9_HUMAN",null,null,"PCYT2"]
["17.2779","17.2569","18.4416","16.874",{"$nulls":3},"'de novo' cotranslational protein folding","ATP binding","cytosol;membrane",{"$nulls":3},3,3,3,"10.6","10.6","10.6","54.794","0.00039526","3.2939",55870000,11,"0.175327","0.845594","-0.390393","-0.498019","sp|Q0VDF9|HSP7E_HUMAN","sp|Q0VDF9|HSP7E_HUMAN",1485,"Q0VDF9","HSP7E_HUMAN","Heat shock 70 kDa protein 14",null,"HSPA14"]
[1,"15.1007",1,"15.8818",{"$nulls":3},"DNA repair;maintenance of DNA repeat elements;mismatch repair;negative regulation of DNA recombination;positive regulation of helicase activity;somatic recombination of immunoglobulin gene segments","ATP binding;damaged DNA binding;DNA-dependent ATPase activity;double-strand/single-strand DNA junction binding;enzyme binding;heteroduplex DNA loop binding;Y-form DNA binding","membrane;MutSbeta complex;nucleoplasm","Colorectal cancer;Mismatch repair;Pathways in cancer;Platinum drug resistance",null,null,1,1,1,"0.8","0.8","0.8","127.41","0.0047202","1.9398",10211000,5,"0.0118569","0.982106","-0.390564","-0.0381016","sp|P20585|MSH3_HUMAN","sp|P20585|MSH3_HUMAN",743,"P20585","MSH3_HUMAN","DNA mismatch repair protein Msh3","MSH3","MSH3"]
["18.1893","18.5864","19.3738","18.1838",{"$nulls":4},"GTP binding",{"$nulls":4},3,3,3,12,12,12,"52.145",0,"9.5976",102280000,21,"0.224273","0.797065","-0.391003","-0.623362","tr|E7EW69|E7EW69_HUMAN;sp|Q9P0V9|SEP10_HUMAN;tr|E7EX04|E7EX04_HUMAN;tr|B5ME97|B5ME97_HUMAN;tr|C9JEW2|C9JEW2_HUMAN;tr|C9JNR7|C9JNR7_HUMAN","tr|E7EW69|E7EW69_HUMAN;sp|Q9P0V9|SEP10_HUMAN;tr|E7EX04|E7EX04_HUMAN;tr|B5ME97|B5ME97_HUMAN",2776,"E7EW69","E7EW69_HUMAN",null,null,"SEPT10"]
["21.6642","21.8261","21.968","22.3047",{"$nulls":3},"beta-catenin destruction complex disassembly;branching morphogenesis of an epithelial tube;cell cycle;cell division;circadian regulation of gene expression;dephosphorylation;entrainment of circadian clock by photoperiod;glycogen metabolic process;lung development;negative regulation of protein binding;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;protein dephosphorylation;regulation of canonical Wnt signaling pathway;regulation of circadian rhythm;regulation of glycogen biosynthetic process;regulation of glycogen catabolic process;regulation of translational initiation by eIF2 alpha dephosphorylation","cadherin binding involved in cell-cell adhesion;metal ion binding;phosphatase activity;phosphoprotein phosphatase activity;protein complex binding;protein phosphatase 1 binding;protein serine/threonine phosphatase activity;ribonucleoprotein complex binding","cell-cell adherens junction;cytoplasm;cytosol;dendritic spine;extracellular exosome;glycogen granule;nucleolus;nucleoplasm;nucleus;perikaryon;plasma membrane;protein phosphatase type 1 complex;PTW/PP1 phosphatase complex","Adrenergic signaling in cardiomyocytes;Alcoholism;Amphetamine addiction;cAMP signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Dopaminergic synapse;Focal adhesion;Herpes simplex virus 1 infection;Hippo signaling pathway;Inflammatory mediator regulation of TRP channels;Insulin resistance;Insulin signaling pathway;Long-term potentiation;mRNA surveillance pathway;Oocyte meiosis;Oxytocin signaling pathway;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Vascular smooth muscle contraction",null,null,7,7,3,"25.2","25.2","11.8","37.512",0,"39.481",762110000,45,"0.76622","0.338427","-0.391192","-2.09386","sp|P62136|PP1A_HUMAN;tr|E9PMD7|E9PMD7_HUMAN;sp|P62140|PP1B_HUMAN;tr|C9J9S3|C9J9S3_HUMAN;tr|C9JP48|C9JP48_HUMAN;tr|E7ETD8|E7ETD8_HUMAN;tr|F5H1L6|F5H1L6_HUMAN;tr|F5H037|F5H037_HUMAN;tr|F8WE71|F8WE71_HUMAN","sp|P62136|PP1A_HUMAN;tr|E9PMD7|E9PMD7_HUMAN;sp|P62140|PP1B_HUMAN",1289,"P62136","PP1A_HUMAN","Serine/threonine-protein phosphatase PP1-alpha catalytic subunit","P-1A","PPP1CA"]
["20.3308","20.7138","20.6632","21.1644",{"$nulls":3},"axon target recognition;cellular response to interferon-gamma;developmental process involved in reproduction;glutamate secretion;long term synaptic depression;negative regulation of neuron apoptotic process;negative regulation of protein complex assembly;negative regulation of synaptic transmission, GABAergic;neuromuscular synaptic transmission;neurotransmitter secretion;platelet aggregation;platelet degranulation;positive regulation of calcium ion-dependent exocytosis;positive regulation of glutamate secretion, neurotransmission;positive regulation of mast cell degranulation;positive regulation of vesicle docking;presynaptic dense core vesicle exocytosis;protein localization to plasma membrane;protein stabilization;protein transport;regulation of SNARE complex assembly;regulation of synaptic vesicle fusion to presynaptic active zone membrane;regulation of synaptic vesicle priming;response to estradiol;synaptic vesicle maturation;vesicle docking involved in exocytosis","identical protein binding;phospholipase binding;protein domain specific binding;protein kinase binding;protein N-terminus binding;RNA binding;SNARE binding;syntaxin binding;syntaxin-1 binding","cytoplasm;cytoskeleton;cytosol;extracellular exosome;mitochondrion;myelin sheath;nucleoplasm;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;platelet alpha granule;postsynapse;presynaptic active zone membrane;protein complex;terminal bouton","Synaptic vesicle cycle",null,null,10,10,10,"22.4","22.4","22.4","67.568",0,"39.837",525310000,41,"0.468074","0.535508","-0.391498","-1.24124","sp|P61764|STXB1_HUMAN;tr|A0A096LP52|A0A096LP52_HUMAN","sp|P61764|STXB1_HUMAN",1279,"P61764","STXB1_HUMAN","Syntaxin-binding protein 1",null,"STXBP1"]
["20.4611","20.5567","21.1136","20.6883",{"$nulls":4},"actin filament binding;calcium ion binding",{"$nulls":4},1,1,1,"10.3","10.3","10.3","11.341",0,"4.2124",73392000,2,"0.669974","0.38689","-0.392053","-1.79915","tr|Q5JUP3|Q5JUP3_HUMAN;sp|Q9BQI0|AIF1L_HUMAN","tr|Q5JUP3|Q5JUP3_HUMAN;sp|Q9BQI0|AIF1L_HUMAN",2421,"Q5JUP3","Q5JUP3_HUMAN",null,null,"AIF1L"]
["19.0174","18.6974","19.5068","18.9924",{"$nulls":3},"actin cytoskeleton organization;caveola assembly;caveolin-mediated endocytosis;cell projection morphogenesis;membrane organization;negative regulation of endocytosis;plasma membrane tubulation;protein localization to endosome;regulation of endocytosis","cadherin binding;cytoskeletal protein binding;identical protein binding;phosphatidic acid binding;transporter activity","caveola;cell-cell junction;cytoplasm;cytoplasmic vesicle membrane;cytoskeleton;cytosol;early endosome;extracellular exosome;extrinsic component of membrane;focal adhesion;intracellular membrane-bounded organelle;nuclear speck;plasma membrane;recycling endosome membrane;ruffle membrane",{"$nulls":3},9,9,9,"32.7","32.7","32.7","55.738",0,"40.756",206410000,19,"0.488534","0.524609","-0.392193","-1.29491","sp|Q9UNF0|PACN2_HUMAN;tr|H0Y923|H0Y923_HUMAN;tr|B0QYG7|B0QYG7_HUMAN;tr|B0QYG8|B0QYG8_HUMAN","sp|Q9UNF0|PACN2_HUMAN",2909,"Q9UNF0","PACN2_HUMAN","Protein kinase C and casein kinase substrate in neurons protein 2",null,"PACSIN2"]
["21.6932","21.4265","22.1758","21.7289",{"$nulls":3},"carbohydrate metabolic process","hydrolase activity, hydrolyzing O-glycosyl compounds",{"$nulls":4},5,5,5,"35.1","35.1","35.1","23.139",0,"12.321",338320000,26,"0.567924","0.468333","-0.3925","-1.50858","tr|H0Y9B6|H0Y9B6_HUMAN;tr|Q5URX0|Q5URX0_HUMAN;sp|P07686|HEXB_HUMAN;tr|H0YA83|H0YA83_HUMAN;tr|D6REQ8|D6REQ8_HUMAN","tr|H0Y9B6|H0Y9B6_HUMAN;tr|Q5URX0|Q5URX0_HUMAN;sp|P07686|HEXB_HUMAN;tr|H0YA83|H0YA83_HUMAN",545,"H0Y9B6","H0Y9B6_HUMAN",null,null,"HEXB"]
["22.384","22.1212","22.7605","22.5301",{"$nulls":3},"cellular potassium ion homeostasis;cellular sodium ion homeostasis;ion transmembrane transport;leukocyte migration;membrane repolarization;positive regulation of ATPase activity;positive regulation of potassium ion import;positive regulation of potassium ion transmembrane transporter activity;positive regulation of sodium ion export across plasma membrane;potassium ion import;protein localization to plasma membrane;protein stabilization;regulation of cardiac conduction;sodium ion export across plasma membrane;transport","ATPase activator activity;ATPase binding;sodium:potassium-exchanging ATPase activity","caveola;extracellular exosome;melanosome;plasma membrane;sodium:potassium-exchanging ATPase complex","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Aldosterone-regulated sodium reabsorption;Bile secretion;cAMP signaling pathway;Carbohydrate digestion and absorption;Cardiac muscle contraction;cGMP-PKG signaling pathway;Endocrine and other factor-regulated calcium reabsorption;Gastric acid secretion;Insulin secretion;Mineral absorption;Pancreatic secretion;Protein digestion and absorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Thyroid hormone signaling pathway;Thyroid hormone synthesis",null,null,6,6,6,"21.1","21.1","21.1","31.512",0,"31.526",680910000,34,"0.813395","0.32286","-0.392637","-2.24696","sp|P54709|AT1B3_HUMAN;tr|C9JA36|C9JA36_HUMAN;tr|C9JXZ1|C9JXZ1_HUMAN;tr|H7C4L9|H7C4L9_HUMAN;tr|H7C547|H7C547_HUMAN;tr|F8WBY4|F8WBY4_HUMAN","sp|P54709|AT1B3_HUMAN;tr|C9JA36|C9JA36_HUMAN;tr|C9JXZ1|C9JXZ1_HUMAN",1194,"P54709","AT1B3_HUMAN","Sodium/potassium-transporting ATPase subunit beta-3",null,"ATP1B3"]
["23.5285","23.1914","23.7408","23.766",{"$nulls":3},"negative regulation of protein neddylation;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of ubiquitin protein ligase activity;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of gene expression;positive regulation of translation;protein stabilization;regulation of signal transduction by p53 class mediator;ribosomal large subunit assembly;ribosomal large subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","5S rRNA binding;mRNA 3'-UTR binding;mRNA 5'-UTR binding;RNA binding;structural constituent of ribosome;ubiquitin ligase inhibitor activity;ubiquitin protein ligase binding","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;protein complex","Ribosome",null,null,5,5,5,"20.5","20.5","20.5","34.362",0,"77.843",1410300000,45,"0.837476","0.314677","-0.393441","-2.32753","sp|P46777|RL5_HUMAN;tr|Q5T7N0|Q5T7N0_HUMAN","sp|P46777|RL5_HUMAN",1032,"P46777","RL5_HUMAN","60S ribosomal protein L5",null,"RPL5"]
["21.0002","21.0187","21.5454","21.2609",{"$nulls":3},"GDP-mannose biosynthetic process","phosphomannomutase activity","cytoplasm",{"$nulls":3},2,2,2,"18.3","18.3","18.3","16.223","0.00076717","2.9866",202030000,4,"0.958832","0.295015","-0.393717","-2.76129","tr|H3BPH4|H3BPH4_HUMAN;tr|H3BV55|H3BV55_HUMAN;sp|O15305|PMM2_HUMAN","tr|H3BPH4|H3BPH4_HUMAN;tr|H3BV55|H3BV55_HUMAN;sp|O15305|PMM2_HUMAN",212,"H3BPH4","H3BPH4_HUMAN","Phosphomannomutase {ECO:0000256|RuleBase:RU361118}",null,"PMM2"]
["19.2539","19.9425","20.3389","19.6464",{"$nulls":4},"nucleic acid binding",{"$nulls":4},5,5,5,"34.7","34.7","34.7","20.083",0,"12.384",82068000,16,"0.297564","0.733882","-0.394449","-0.807808","tr|I3L0X5|I3L0X5_HUMAN;tr|I3L4C3|I3L4C3_HUMAN;sp|O75391|SPAG7_HUMAN;tr|I3L0Q5|I3L0Q5_HUMAN","tr|I3L0X5|I3L0X5_HUMAN;tr|I3L4C3|I3L4C3_HUMAN;sp|O75391|SPAG7_HUMAN",340,"I3L0X5","I3L0X5_HUMAN",null,null,"SPAG7"]
["19.0488","18.4943","19.1662","19.1666",{"$nulls":3},"apoptotic process;BMP signaling pathway;cell aging;cellular response to lipopolysaccharide;epithelial to mesenchymal transition involved in cardiac fibroblast development;interleukin-12-mediated signaling pathway;negative regulation of apoptotic process;negative regulation of cell cycle;negative regulation of cytokine production involved in inflammatory response;negative regulation of JUN kinase activity;negative regulation of myofibroblast differentiation;negative regulation of transcription, DNA-templated;negative regulation of vascular smooth muscle cell differentiation;positive regulation of endothelial cell apoptotic process;positive regulation of inflammatory response;positive regulation of NIK/NF-kappaB signaling;positive regulation of smooth muscle cell apoptotic process","RNA binding","cytoplasm;cytosol;nucleus","MicroRNAs in cancer;Proteoglycans in cancer",null,null,5,5,5,"16.6","16.6","16.6","51.735",0,"14.045",85200000,14,"0.537023","0.490401","-0.394871","-1.42429","sp|Q53EL6|PDCD4_HUMAN;tr|Q5VZS7|Q5VZS7_HUMAN","sp|Q53EL6|PDCD4_HUMAN;tr|Q5VZS7|Q5VZS7_HUMAN",1791,"Q53EL6","PDCD4_HUMAN","Programmed cell death protein 4",null,"PDCD4"]
["14.8086","14.954","15.8374","14.7158",{"$nulls":3},"negative regulation of transcription, DNA-templated","DNA binding transcription factor activity;metal ion binding;nucleic acid binding","nucleus",{"$nulls":3},1,1,1,"4.3","4.3","4.3","45.112","0.0011223","2.788",8956600,1,"0.254264","0.769728","-0.39535","-0.699107","tr|V9GY48|V9GY48_HUMAN;sp|Q8N5A5|ZGPAT_HUMAN","tr|V9GY48|V9GY48_HUMAN;sp|Q8N5A5|ZGPAT_HUMAN",2055,"V9GY48","V9GY48_HUMAN"]
["18.4252","18.3421","19.0879","18.4704",{"$nulls":3},"protein homotetramerization;tRNA modification;tRNA processing","ATP binding;GTP binding;identical protein binding;magnesium ion binding;nucleotidyltransferase activity;tRNA binding;tRNA guanylyltransferase activity","cytosol;mitochondrion",{"$nulls":3},1,1,1,"3.7","3.7","3.7","34.83","0.0047619","2.0064",54913000,6,"0.478941","0.525898","-0.395515","-1.26968","sp|Q9NWX6|THG1_HUMAN","sp|Q9NWX6|THG1_HUMAN",2731,"Q9NWX6","THG1_HUMAN","Probable tRNA(His) guanylyltransferase",null,"THG1L"]
["22.2828","22.2549","22.8742","22.4554",{"$nulls":3},"cell proliferation;DNA double-strand break processing;double-strand break repair via nonhomologous end joining;error-free postreplication DNA repair;global genome nucleotide-excision repair;negative regulation of neuron apoptotic process;positive regulation of DNA repair;positive regulation of neuron projection development;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of synapse assembly;postreplication repair;protein K63-linked ubiquitination;protein polyubiquitination;protein ubiquitination;regulation of DNA repair","ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding","cytoplasm;extracellular exosome;nucleoplasm;nucleus;UBC13-MMS2 complex",{"$nulls":3},6,6,2,"44.1","44.1","17.2","16.363",0,"13.173",633330000,26,"0.699401","0.366671","-0.395982","-1.88692","sp|Q15819|UB2V2_HUMAN;tr|G3V113|G3V113_HUMAN;tr|H0YBP9|H0YBP9_HUMAN;tr|H0YBX6|H0YBX6_HUMAN;tr|E5RIF1|E5RIF1_HUMAN;tr|D6RG00|D6RG00_HUMAN","sp|Q15819|UB2V2_HUMAN;tr|G3V113|G3V113_HUMAN;tr|H0YBP9|H0YBP9_HUMAN;tr|H0YBX6|H0YBX6_HUMAN",1725,"Q15819","UB2V2_HUMAN","Ubiquitin-conjugating enzyme E2 variant 2",null,"UBE2V2"]
["26.7155","26.7548","27.5489","26.7142",{"$nulls":3},"ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;microtubule-based process;movement of cell or subcellular component;natural killer cell mediated cytotoxicity;neutrophil degranulation;regulation of G2/M transition of mitotic cell cycle","double-stranded RNA binding;GTP binding;GTPase activity;MHC class I protein binding;structural constituent of cytoskeleton;unfolded protein binding","azurophil granule lumen;cytoskeleton;cytosol;extracellular exosome;extracellular matrix;extracellular region;extracellular vesicle;microtubule;microtubule cytoskeleton;myelin sheath;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,22,22,1,"63.8","63.8","2.7","49.83",0,"323.31",29953000000,510,"0.353718","0.683034","-0.396403","-0.948777","sp|P68371|TBB4B_HUMAN;tr|M0R2D3|M0R2D3_HUMAN;tr|I3L2F9|I3L2F9_HUMAN;sp|A6NNZ2|TBB8L_HUMAN;sp|Q9H4B7|TBB1_HUMAN;CON__ENSEMBL:ENSBTAP00000025008;tr|M0R2T4|M0R2T4_HUMAN;tr|A0A075B724|A0A075B724_HUMAN","sp|P68371|TBB4B_HUMAN",1360,"P68371","TBB4B_HUMAN","Tubulin beta-4B chain",null,"TUBB4B"]
["19.8557","20.0158","20.5813","20.083",{"$nulls":3},"canonical glycolysis;fructose 1,6-bisphosphate metabolic process;fructose 6-phosphate metabolic process;glycolytic process;negative regulation of insulin secretion;neutrophil degranulation;protein homotetramerization;protein oligomerization;response to glucose","6-phosphofructokinase activity;ATP binding;fructose binding;fructose-6-phosphate binding;identical protein binding;kinase binding;metal ion binding","6-phosphofructokinase complex;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;secretory granule lumen","AMPK signaling pathway;Biosynthesis of amino acids;Carbon metabolism;Central carbon metabolism in cancer;Fructose and mannose metabolism;Galactose metabolism;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Pentose phosphate pathway;RNA degradation",null,null,7,7,5,"10.6","10.6","7.1","85.018",0,"19.577",410440000,25,"0.57027","0.466422","-0.396469","-1.51504","sp|P17858|PFKAL_HUMAN","sp|P17858|PFKAL_HUMAN",713,"P17858","PFKAL_HUMAN","ATP-dependent 6-phosphofructokinase, liver type {ECO:0000255|HAMAP-Rule:MF_03184}","FK-L;TP-PFK {ECO:0000255|HAMAP-Rule:MF_03184}","PFKL"]
["21.0303","20.9577","21.5148","21.2663",{"$nulls":3},"protein oligomerization;regulation of RNA splicing;regulation of voltage-gated calcium channel activity","cadherin binding;RNA binding;S100 protein binding;structural molecule activity conferring elasticity","actin cytoskeleton;cell-cell contact zone;costamere;cytoplasm;cytosol;extracellular exosome;focal adhesion;lysosomal membrane;membrane;nucleus;plasma membrane;sarcolemma;T-tubule;vesicle",{"$nulls":3},118,118,118,"37.1","37.1","37.1","629.09",0,"323.31",10759000000,591,"1.03585","0.299426","-0.396525","-3.06342","sp|Q09666|AHNK_HUMAN;tr|E9PQE3|E9PQE3_HUMAN;tr|E9PJZ0|E9PJZ0_HUMAN;tr|E9PKR9|E9PKR9_HUMAN;tr|E9PJC6|E9PJC6_HUMAN;tr|E9PLK4|E9PLK4_HUMAN;sp|P48552|NRIP1_HUMAN","sp|Q09666|AHNK_HUMAN",1484,"Q09666","AHNK_HUMAN","Neuroblast differentiation-associated protein AHNAK",null,"AHNAK"]
["23.9129","24.0294","24.1837","24.5519",{"$nulls":9},1,1,1,"19.3","19.3","19.3","6.2542",0,"4.4297",432420000,4,"0.753547","0.338845","-0.396641","-2.05375","tr|F5H7R9|F5H7R9_HUMAN;sp|P20962|PTMS_HUMAN;tr|F5GXR3|F5GXR3_HUMAN","tr|F5H7R9|F5H7R9_HUMAN;sp|P20962|PTMS_HUMAN;tr|F5GXR3|F5GXR3_HUMAN",750,"F5H7R9","F5H7R9_HUMAN",null,null,"PTMS"]
["21.428","21.4085","22.3234","21.3066",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;neutrophil degranulation;signal transduction;thrombin-activated receptor signaling pathway","actin binding;actin filament binding;Arp2/3 complex binding;calmodulin binding;GTPase inhibitor activity;phosphatidylinositol-3,4,5-trisphosphate binding;Rac GTPase binding;Rho GTPase binding","actin cytoskeleton;cell surface;cytoplasm;cytosol;extracellular exosome;filopodium;lamellipodium;microtubule;microvillus;plasma membrane;secretory granule membrane","Regulation of actin cytoskeleton",null,null,42,42,41,39,39,"38.5","180.58",0,"323.31",2608900000,179,"0.286592","0.744824","-0.396749","-0.7803","sp|Q13576|IQGA2_HUMAN;tr|F5H7S7|F5H7S7_HUMAN;tr|E7EWC2|E7EWC2_HUMAN;tr|D6R939|D6R939_HUMAN;tr|E9PDT6|E9PDT6_HUMAN;tr|D6RDK8|D6RDK8_HUMAN","sp|Q13576|IQGA2_HUMAN;tr|F5H7S7|F5H7S7_HUMAN;tr|E7EWC2|E7EWC2_HUMAN",1574,"Q13576","IQGA2_HUMAN","Ras GTPase-activating-like protein IQGAP2",null,"IQGAP2"]
["21.3706","21.3449","22.05","21.4596",{"$nulls":4},"hydrolase activity",{"$nulls":4},6,6,6,"39.8","39.8","39.8","20.629",0,"12.68",251300000,17,"0.507072","0.514684","-0.397111","-1.34399","tr|A6NJU6|A6NJU6_HUMAN;sp|Q9UKK9|NUDT5_HUMAN;tr|A6NFX8|A6NFX8_HUMAN;tr|A6NCQ0|A6NCQ0_HUMAN;tr|C9JYY9|C9JYY9_HUMAN;tr|H0YEY4|H0YEY4_HUMAN","tr|A6NJU6|A6NJU6_HUMAN;sp|Q9UKK9|NUDT5_HUMAN;tr|A6NFX8|A6NFX8_HUMAN;tr|A6NCQ0|A6NCQ0_HUMAN;tr|C9JYY9|C9JYY9_HUMAN",2873,"A6NJU6","A6NJU6_HUMAN",null,null,"NUDT5"]
["17.0289","16.9863","17.7769","17.0325",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;microtubule-based movement;retrograde vesicle-mediated transport, Golgi to ER","cadherin binding;kinesin binding;microtubule motor activity","cytosol;kinesin complex;kinesin I complex;membrane;microtubule;protein complex","Salmonella infection",null,null,8,6,5,"20.3","17.4","15.4","68.934",0,"19.245",82044000,18,"0.39977","0.621406","-0.397134","-1.06532","sp|Q9H0B6|KLC2_HUMAN;tr|A8MZ87|A8MZ87_HUMAN;tr|A8MX29|A8MX29_HUMAN;tr|E9PQ02|E9PQ02_HUMAN;tr|E9PP09|E9PP09_HUMAN;tr|C9JHT2|C9JHT2_HUMAN;tr|E9PM83|E9PM83_HUMAN;tr|E9PI24|E9PI24_HUMAN","sp|Q9H0B6|KLC2_HUMAN;tr|A8MZ87|A8MZ87_HUMAN;tr|A8MX29|A8MX29_HUMAN",2555,"Q9H0B6","KLC2_HUMAN","Kinesin light chain 2","LC 2","KLC2"]
["23.1256","22.8921","23.683","23.129",{"$nulls":3},"axon guidance;brain development;cytoskeleton organization;endocytosis;nervous system development;nucleobase-containing compound metabolic process;regulation of axon extension;signal transduction","dihydropyrimidinase activity;identical protein binding;microtubule binding","cytoskeleton;cytosol;extracellular exosome;plasma membrane","Axon guidance",null,null,18,18,14,"53.7","53.7","43.7","62.293",0,"260.27",2607500000,131,"0.498453","0.513694","-0.397141","-1.32111","sp|Q16555|DPYL2_HUMAN;tr|E5RFU4|E5RFU4_HUMAN;tr|D6RF19|D6RF19_HUMAN","sp|Q16555|DPYL2_HUMAN",1743,"Q16555","DPYL2_HUMAN","Dihydropyrimidinase-related protein 2","RP-2","DPYSL2"]
["17.9235","17.3477","18.4049","17.6614",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;endosome to melanosome transport;Golgi to lysosome transport;intracellular protein transport;melanosome organization;positive regulation of natural killer cell degranulation;positive regulation of natural killer cell mediated cytotoxicity;regulation of defense response to virus by virus","GTP-dependent protein binding;kinesin binding;protein transporter activity;Rab GTPase binding;transporter activity","AP-type membrane coat adaptor complex;clathrin adaptor complex;clathrin-coated endocytic vesicle membrane;clathrin-coated vesicle;clathrin-coated vesicle membrane;cytoplasm;cytoplasmic vesicle membrane;cytosol;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle;lysosomal membrane;membrane;recycling endosome;trans-Golgi network membrane","Human immunodeficiency virus 1 infection;Lysosome",null,null,3,3,3,"7.7","7.7","7.7","91.35",0,"28.974",67621000,8,"0.312555","0.714345","-0.397514","-0.845389","sp|O43747|AP1G1_HUMAN;tr|H3BN75|H3BN75_HUMAN;tr|H3BS13|H3BS13_HUMAN;tr|H3BV30|H3BV30_HUMAN;tr|H3BRM7|H3BRM7_HUMAN;tr|H3BN71|H3BN71_HUMAN;tr|B4DGE1|B4DGE1_HUMAN;tr|H3BR36|H3BR36_HUMAN;tr|H3BUN9|H3BUN9_HUMAN;tr|H3BNR4|H3BNR4_HUMAN","sp|O43747|AP1G1_HUMAN",263,"O43747","AP1G1_HUMAN","AP-1 complex subunit gamma-1",null,"AP1G1"]
["22.0901","22.0164","22.776","22.1261",{"$nulls":3},"beta-catenin-TCF complex assembly;box C/D snoRNP assembly;cell cycle;cell division;CENP-A containing nucleosome assembly;chromatin remodeling;DNA recombination;DNA repair;histone H2A acetylation;histone H4 acetylation;positive regulation of protein targeting to mitochondrion;positive regulation of telomerase RNA localization to Cajal body;protein deubiquitination;regulation of autophagy of mitochondrion;regulation of growth;regulation of transcription from RNA polymerase II promoter;spermatogenesis;transcription, DNA-templated","ADP binding;ATP binding;ATPase activity;ATPase binding;ATP-dependent 5'-3' DNA helicase activity;ATP-dependent DNA helicase activity;cadherin binding;DNA helicase activity;TFIID-class transcription factor binding","cytosol;extracellular exosome;Ino80 complex;intracellular ribonucleoprotein complex;membrane;microtubule organizing center;MLL1 complex;NuA4 histone acetyltransferase complex;nuclear matrix;nucleoplasm;nucleus;R2TP complex;Swr1 complex","Wnt signaling pathway",null,null,8,8,8,"26.8","26.8","26.8","50.227",0,"54.769",1042300000,40,"0.458541","0.544961","-0.397825","-1.21641","sp|Q9Y265|RUVB1_HUMAN;tr|H7C4G5|H7C4G5_HUMAN;tr|E7ETR0|E7ETR0_HUMAN;tr|J3QLR1|J3QLR1_HUMAN;tr|H7C4I3|H7C4I3_HUMAN","sp|Q9Y265|RUVB1_HUMAN;tr|H7C4G5|H7C4G5_HUMAN;tr|E7ETR0|E7ETR0_HUMAN",2941,"Q9Y265","RUVB1_HUMAN","RuvB-like 1",null,"RUVBL1"]
["23.2385","23.1379","23.7691","23.4033",{"$nulls":3},"cardiac muscle cell action potential involved in contraction;cell communication by electrical coupling involved in cardiac conduction;cellular potassium ion homeostasis;cellular response to mechanical stimulus;cellular response to steroid hormone stimulus;cellular sodium ion homeostasis;ion transmembrane transport;membrane hyperpolarization;membrane repolarization;membrane repolarization during cardiac muscle cell action potential;negative regulation of glucocorticoid biosynthetic process;negative regulation of heart contraction;positive regulation of heart contraction;positive regulation of striated muscle contraction;potassium ion import;potassium ion import across plasma membrane;regulation of blood pressure;regulation of cardiac conduction;regulation of cardiac muscle cell contraction;regulation of sodium ion transport;regulation of the force of heart contraction;relaxation of cardiac muscle;response to drug;response to glycoside;sodium ion export across plasma membrane","ADP binding;ankyrin binding;ATP binding;chaperone binding;phosphatase activity;phosphatidylinositol 3-kinase binding;potassium ion binding;protein domain specific binding;protein kinase binding;sodium ion binding;sodium:potassium-exchanging ATPase activity;steroid hormone binding","apical plasma membrane;basolateral plasma membrane;caveola;endoplasmic reticulum;endosome;extracellular exosome;extracellular vesicle;Golgi apparatus;integral component of membrane;intercalated disc;melanosome;membrane;myelin sheath;plasma membrane;postsynaptic density;protein complex;sarcolemma;sodium:potassium-exchanging ATPase complex;T-tubule","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Aldosterone-regulated sodium reabsorption;Bile secretion;cAMP signaling pathway;Carbohydrate digestion and absorption;Cardiac muscle contraction;cGMP-PKG signaling pathway;Endocrine and other factor-regulated calcium reabsorption;Gastric acid secretion;Insulin secretion;Mineral absorption;Pancreatic secretion;Protein digestion and absorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Thyroid hormone signaling pathway;Thyroid hormone synthesis",null,null,25,25,25,"30.1","30.1","30.1","112.89",0,"323.31",4394000000,170,"0.767546","0.337537","-0.398014","-2.09808","sp|P05023|AT1A1_HUMAN;tr|M0R116|M0R116_HUMAN;sp|P13637|AT1A3_HUMAN;tr|A0A0A0MT26|A0A0A0MT26_HUMAN;tr|B1AKY9|B1AKY9_HUMAN;sp|P50993|AT1A2_HUMAN;tr|H0Y7C1|H0Y7C1_HUMAN;sp|Q13733|AT1A4_HUMAN;tr|Q5TC01|Q5TC01_HUMAN;tr|Q5TC02|Q5TC02_HUMAN;tr|M0QXF2|M0QXF2_HUMAN;tr|E9PRA5|E9PRA5_HUMAN;sp|P20648|ATP4A_HUMAN;sp|P54707|AT12A_HUMAN","sp|P05023|AT1A1_HUMAN",507,"P05023","AT1A1_HUMAN","Sodium/potassium-transporting ATPase subunit alpha-1","a(+)/K(+) ATPase alpha-1 subunit","ATP1A1"]
["21.7206","21.5936","22.1534","21.958",{"$nulls":3},"threonyl-tRNA aminoacylation;translation;tRNA aminoacylation for protein translation","ATP binding;protein homodimerization activity;threonine-tRNA ligase activity;tRNA binding","actin cytoskeleton;cytoplasm;cytosol;extracellular exosome","Aminoacyl-tRNA biosynthesis",null,null,19,19,19,"32.4","32.4","32.4","83.434",0,"64.523",1752700000,81,"1.1202","0.309835","-0.398567","-3.42176","sp|P26639|SYTC_HUMAN;tr|D6RCA5|D6RCA5_HUMAN;tr|D6R9F8|D6R9F8_HUMAN;tr|D6RDJ6|D6RDJ6_HUMAN;tr|D6RBR8|D6RBR8_HUMAN;tr|D6RJ97|D6RJ97_HUMAN;tr|D6RHV7|D6RHV7_HUMAN;tr|D6RCS6|D6RCS6_HUMAN","sp|P26639|SYTC_HUMAN",815,"P26639","SYTC_HUMAN","Threonine--tRNA ligase, cytoplasmic",null,"TARS"]
["22.0615","21.7546","22.5662","22.0476",{"$nulls":3},"3'-UTR-mediated mRNA destabilization;cellular response to cytokine stimulus;miRNA metabolic process;mRNA catabolic process;mRNA processing;mRNA transport;negative regulation of nitric oxide biosynthetic process;positive regulation of mRNA catabolic process;regulation of miRNA metabolic process;regulation of mRNA stability;regulation of transcription, DNA-templated;RNA splicing;RNA splicing, via transesterification reactions;transcription, DNA-templated","DNA binding;mRNA 3'-UTR AU-rich region binding;RNA binding","cytoplasmic stress granule;cytosol;membrane;nucleoplasm",{"$nulls":3},11,11,11,"27.7","27.7","27.7","73.114",0,"84.818",1373200000,71,"0.499479","0.513692","-0.39885","-1.32383","sp|Q92945|FUBP2_HUMAN;tr|A0A087WTP3|A0A087WTP3_HUMAN;tr|M0R0I5|M0R0I5_HUMAN;tr|M0QYH3|M0QYH3_HUMAN;tr|M0QXW7|M0QXW7_HUMAN;tr|M0R0C6|M0R0C6_HUMAN;tr|M0R3J3|M0R3J3_HUMAN;tr|M0R251|M0R251_HUMAN;tr|M0QYG1|M0QYG1_HUMAN;tr|M0R263|M0R263_HUMAN","sp|Q92945|FUBP2_HUMAN;tr|A0A087WTP3|A0A087WTP3_HUMAN;tr|M0R0I5|M0R0I5_HUMAN",2207,"Q92945","FUBP2_HUMAN","Far upstream element-binding protein 2","USE-binding protein 2","KHSRP"]
["21.8143","21.4873","22.4279","21.672",{"$nulls":9},5,5,5,"26.6","26.6","26.6","29.755",0,"19.551",765480000,24,"0.361855","0.667584","-0.399122","-0.969283","tr|E9PL38|E9PL38_HUMAN;tr|J3KNQ3|J3KNQ3_HUMAN;sp|Q9UNM6|PSD13_HUMAN;tr|A0A087WUL9|A0A087WUL9_HUMAN;tr|H0YD73|H0YD73_HUMAN;tr|E9PPD2|E9PPD2_HUMAN;tr|F8W8J6|F8W8J6_HUMAN;tr|E9PQG3|E9PQG3_HUMAN","tr|E9PL38|E9PL38_HUMAN;tr|J3KNQ3|J3KNQ3_HUMAN;sp|Q9UNM6|PSD13_HUMAN;tr|A0A087WUL9|A0A087WUL9_HUMAN;tr|H0YD73|H0YD73_HUMAN",2914,"E9PL38","E9PL38_HUMAN",null,null,"PSMD13"]
["17.3163","17.2352","17.8963","17.4534",{"$nulls":3},"methylation;nucleobase-containing compound metabolic process","thiopurine S-methyltransferase activity","cytosol;extracellular exosome","Drug metabolism - other enzymes",null,null,1,1,1,"4.9","4.9","4.9","28.18","0.0010985","2.619",26239000,1,"0.660953","0.38997","-0.399127","-1.77262","sp|P51580|TPMT_HUMAN","sp|P51580|TPMT_HUMAN",1139,"P51580","TPMT_HUMAN","Thiopurine S-methyltransferase",null,"TPMT"]
["17.4225","17.3721","18.2797","17.3134",{"$nulls":3},"immune response;positive regulation of cell migration;protein complex assembly;protein phosphorylation;regulation of transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;tRNA wobble uridine modification","phosphorylase kinase regulator activity;signal transducer activity","cytoplasm;cytosol;Elongator holoenzyme complex;histone acetyltransferase complex;nucleolus;transcription elongation factor complex",{"$nulls":3},8,8,8,"9.1","9.1","9.1","150.25",0,"13.64",140920000,12,"0.304541","0.724728","-0.399268","-0.825297","sp|O95163|ELP1_HUMAN;tr|F5H2T0|F5H2T0_HUMAN","sp|O95163|ELP1_HUMAN;tr|F5H2T0|F5H2T0_HUMAN",413,"O95163","ELP1_HUMAN","Elongator complex protein 1","LP1","ELP1"]
["18.1123","18.3109","18.7872","18.4373",{"$nulls":3},"RNA processing",null,"exosome (RNase complex);nucleolus",{"$nulls":3},1,1,1,"2.6","2.6","2.6","46.977","0.0037684","2.0574",49848000,0,"0.733701","0.34913","-0.400634","-1.99177","tr|D6RIY6|D6RIY6_HUMAN;sp|Q06265|EXOS9_HUMAN","tr|D6RIY6|D6RIY6_HUMAN;sp|Q06265|EXOS9_HUMAN",1458,"D6RIY6","D6RIY6_HUMAN"]
["18.3413","17.9425","18.7582","18.3272",{"$nulls":3},"gamma-aminobutyric acid catabolic process","succinate-semialdehyde dehydrogenase [NAD(P)+] activity","mitochondrion",{"$nulls":3},2,2,2,"5.7","5.7","5.7","53.867",0,"5.2474",68958000,12,"0.51495","0.510646","-0.400807","-1.36499","tr|C9J8Q5|C9J8Q5_HUMAN;sp|P51649|SSDH_HUMAN","tr|C9J8Q5|C9J8Q5_HUMAN;sp|P51649|SSDH_HUMAN",1143,"C9J8Q5","C9J8Q5_HUMAN",null,null,"ALDH5A1"]
["23.5458","23.0472","24.0057","23.3902",{"$nulls":3},"multicellular organism development;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of cell proliferation;positive regulation of translation;response to ethanol;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;rRNA binding;structural constituent of ribosome","cytoplasmic ribonucleoprotein granule;cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleoplasm;polysome;ribosome;small ribosomal subunit","Ribosome",null,null,9,9,9,"34.6","34.6","34.6","29.597",0,"42.455",2092000000,52,"0.379411","0.643844","-0.401468","-1.01364","sp|P62701|RS4X_HUMAN;sp|Q8TD47|RS4Y2_HUMAN;tr|A6NH36|A6NH36_HUMAN;tr|C9JEH7|C9JEH7_HUMAN;sp|P22090|RS4Y1_HUMAN","sp|P62701|RS4X_HUMAN",1310,"P62701","RS4X_HUMAN","40S ribosomal protein S4, X isoform",null,"RPS4X"]
["21.9868","22.2988","22.5159","22.5728",{"$nulls":3},"Leydig cell differentiation;male sex determination;mRNA 3'-splice site recognition;mRNA splicing, via spliceosome;negative regulation of smooth muscle cell proliferation;nuclear body organization;regulation of steroid biosynthetic process;regulation of transcription, DNA-templated;spliceosomal complex assembly;transcription, DNA-templated","identical protein binding;pre-mRNA branch point binding;RNA binding;transcription corepressor activity;zinc ion binding","nuclear body;nucleoplasm;nucleus;ribosome;spliceosomal complex",{"$nulls":3},7,7,7,"15.6","15.6","15.6","68.329",0,"89.624",682550000,50,"0.89653","0.299059","-0.401562","-2.53258","sp|Q15637|SF01_HUMAN;tr|C9J792|C9J792_HUMAN;tr|F8WEV5|F8WEV5_HUMAN;tr|H7C561|H7C561_HUMAN","sp|Q15637|SF01_HUMAN",1710,"Q15637","SF01_HUMAN","Splicing factor 1",null,"SF1"]
["16.6505","16.6934","17.5462","16.6049",{"$nulls":3},"mRNA processing","metal ion binding;RNA binding",{"$nulls":4},2,1,1,"2.1",1,1,"114.54","0.0097213","1.6684",43097000,4,"0.317056","0.713771","-0.403588","-0.856675","tr|U3KPZ7|U3KPZ7_HUMAN;sp|Q9P2N5|RBM27_HUMAN","tr|U3KPZ7|U3KPZ7_HUMAN;sp|Q9P2N5|RBM27_HUMAN",2791,"U3KPZ7","U3KPZ7_HUMAN"]
["21.3333","21.4471","22.0826","21.5056",{"$nulls":3},"negative regulation of translational initiation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of mRNA binding;positive regulation of translation;regulation of translational initiation;translational initiation","cadherin binding;protein N-terminus binding;RNA binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 3 complex;extracellular exosome;membrane;nuclear body;nucleoplasm;nucleus;PML body","Hepatitis C;RNA transport",null,null,12,12,12,"31.9","31.9","31.9","52.22",0,"139.52",1013500000,57,"0.51815","0.509233","-0.403898","-1.37354","sp|P60228|EIF3E_HUMAN;tr|E5RGA2|E5RGA2_HUMAN;tr|H0YBR5|H0YBR5_HUMAN;tr|E5RIT4|E5RIT4_HUMAN;tr|E5RHS5|E5RHS5_HUMAN;tr|H0YAW4|H0YAW4_HUMAN;tr|H0YBP5|H0YBP5_HUMAN;tr|E5RII3|E5RII3_HUMAN","sp|P60228|EIF3E_HUMAN;tr|E5RGA2|E5RGA2_HUMAN",1235,"P60228","EIF3E_HUMAN","Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004}","IF3e {ECO:0000255|HAMAP-Rule:MF_03004}","EIF3E"]
["15.9028","15.9668","16.1037","16.5738",{"$nulls":3},"glomerular visceral epithelial cell migration;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;RNA export from nucleus;tRNA export from nucleus;viral process;viral transcription","structural constituent of nuclear pore","host cell;membrane;nuclear envelope;nuclear pore inner ring","RNA transport",null,null,1,1,1,"0.9","0.9","0.9","196.04",0,"35.413",58448000,9,"0.636862","0.4072","-0.403941","-1.70263","sp|Q5SRE5|NU188_HUMAN","sp|Q5SRE5|NU188_HUMAN",1823,"Q5SRE5","NU188_HUMAN","Nucleoporin NUP188 homolog","Nup188","NUP188"]
["23.5787","23.0682","24.1948","23.26",{"$nulls":3},"glucocorticoid catabolic process;glucocorticoid receptor signaling pathway;intracellular protein transport;membrane depolarization during action potential;membrane organization;negative regulation of dendrite morphogenesis;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;positive regulation of transcription, DNA-templated;regulation of neuron differentiation;regulation of sodium ion transmembrane transporter activity;regulation of sodium ion transport;regulation of synaptic plasticity;substantia nigra development","actin binding;enzyme binding;glucocorticoid receptor binding;identical protein binding;insulin-like growth factor receptor binding;ion channel binding;protein domain specific binding;protein heterodimerization activity;sodium channel regulator activity","cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;intercalated disc;mitochondrion;plasma membrane","Cell cycle;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,14,11,11,"55.7","51.6","51.6","28.218",0,"323.31",2038400000,79,"0.27792","0.752682","-0.403981","-0.758548","sp|Q04917|1433F_HUMAN;tr|A2IDB2|A2IDB2_HUMAN;tr|F8WEB6|F8WEB6_HUMAN;tr|A2IDB1|A2IDB1_HUMAN","sp|Q04917|1433F_HUMAN",1448,"Q04917","1433F_HUMAN","14-3-3 protein eta",null,"YWHAH"]
["18.1447","18.5099","18.9041","18.5592",{"$nulls":3},"protein import into nucleus","histone binding;protein transporter activity;Ran GTPase binding","cytoplasm;cytosol;membrane;nuclear envelope",{"$nulls":3},8,8,8,"14.7","14.7","14.7","115.96",0,"36.287",178410000,45,"0.604287","0.430558","-0.404314","-1.60984","sp|Q96P70|IPO9_HUMAN","sp|Q96P70|IPO9_HUMAN",2332,"Q96P70","IPO9_HUMAN","Importin-9","mp9","IPO9"]
["20.3493","20.1509","20.4265","20.8825",{"$nulls":4},"cytochrome-c oxidase activity","extracellular exosome;mitochondrial respiratory chain","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,1,1,1,"15.7","15.7","15.7","9.3959","0.0010925","2.5447",52747000,4,"0.61028","0.428297","-0.404427","-1.62676","sp|P14406|CX7A2_HUMAN;tr|D6RIE3|D6RIE3_HUMAN;tr|D6RGV5|D6RGV5_HUMAN;tr|H0UI06|H0UI06_HUMAN","sp|P14406|CX7A2_HUMAN;tr|D6RIE3|D6RIE3_HUMAN;tr|D6RGV5|D6RGV5_HUMAN;tr|H0UI06|H0UI06_HUMAN",668,"P14406","CX7A2_HUMAN","Cytochrome c oxidase subunit 7A2, mitochondrial",null,"COX7A2"]
["17.8","17.516","19.1345","16.9907",{"$nulls":3},"transcription, DNA-templated","DNA binding;DNA-directed 5'-3' RNA polymerase activity;protein dimerization activity","nucleus",{"$nulls":3},2,2,2,"23.4","23.4","23.4","14.205",0,"5.0166",16898000,8,"0.128301","0.89729","-0.404581","-0.374181","tr|D6RDJ3|D6RDJ3_HUMAN;tr|E7EQB9|E7EQB9_HUMAN;sp|O15160|RPAC1_HUMAN","tr|D6RDJ3|D6RDJ3_HUMAN;tr|E7EQB9|E7EQB9_HUMAN;sp|O15160|RPAC1_HUMAN",203,"D6RDJ3","D6RDJ3_HUMAN",null,null,"POLR1C"]
["23.7957","23.6383","24.3975","23.8457",{"$nulls":3},"chaperone cofactor-dependent protein refolding;negative regulation of protein refolding;protein folding;protein homooligomerization","chaperone binding;dATP binding;Hsp70 protein binding;identical protein binding;protein binding, bridging;protein complex binding;protein dimerization activity;protein domain specific binding;unfolded protein binding","cytoplasm;cytosol;extracellular exosome;protein complex",{"$nulls":3},8,8,8,"27.9","27.9","27.9","41.331",0,"76.697",1917700000,54,"0.531719","0.496052","-0.404586","-1.40998","sp|P50502|F10A1_HUMAN;tr|Q3KNR6|Q3KNR6_HUMAN;tr|F6VDH7|F6VDH7_HUMAN;sp|Q8NFI4|F10A5_HUMAN;tr|H7C3I1|H7C3I1_HUMAN;tr|A0A087X1H6|A0A087X1H6_HUMAN;sp|Q8IZP2|ST134_HUMAN;tr|F8WAQ7|F8WAQ7_HUMAN","sp|P50502|F10A1_HUMAN;tr|Q3KNR6|Q3KNR6_HUMAN;tr|F6VDH7|F6VDH7_HUMAN;sp|Q8NFI4|F10A5_HUMAN;tr|H7C3I1|H7C3I1_HUMAN;tr|A0A087X1H6|A0A087X1H6_HUMAN",1116,"P50502","F10A1_HUMAN","Hsc70-interacting protein","ip","ST13"]
["16.5118","14.217","16.8739","14.6653",{"$nulls":9},2,2,2,"2.7","2.7","2.7","106.01",0,"6.0676",29593000,9,"0.0846458","0.926275","-0.40522","-0.25446","tr|A0A0A0MTP7|A0A0A0MTP7_HUMAN;tr|F8VXG7|F8VXG7_HUMAN;sp|Q99590|SCAFB_HUMAN","tr|A0A0A0MTP7|A0A0A0MTP7_HUMAN;tr|F8VXG7|F8VXG7_HUMAN;sp|Q99590|SCAFB_HUMAN",2385,"A0A0A0MTP7","A0A0A0MTP7_HUMAN",null,null,"SCAF11"]
["18.2596","18.2041","18.9091","18.3656",{"$nulls":3},"cell-cell adhesion",null,"cell junction;nucleoplasm",{"$nulls":3},10,10,10,"21.6","21.6","21.6","91.239",0,"40.682",279420000,27,"0.559199","0.470492","-0.405504","-1.48463","tr|B8QGS9|B8QGS9_HUMAN;sp|Q99959|PKP2_HUMAN;tr|A0A087WXY2|A0A087WXY2_HUMAN","tr|B8QGS9|B8QGS9_HUMAN;sp|Q99959|PKP2_HUMAN",2401,"B8QGS9","B8QGS9_HUMAN",null,null,"PKP2"]
["24.1194","24.3284","24.797","24.4622",{"$nulls":3},"cellular response to heat;neutrophil degranulation;protein refolding;response to unfolded protein","ATP binding;ATPase activity, coupled;enzyme binding;heat shock protein binding;unfolded protein binding","blood microparticle;centriole;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;secretory granule lumen","Antigen processing and presentation;Endocytosis;Estrogen signaling pathway;Legionellosis;Longevity regulating pathway - multiple species;MAPK signaling pathway;Measles;Protein processing in endoplasmic reticulum;Spliceosome;Toxoplasmosis",null,null,7,1,1,"12.4","1.7","1.7","71.027",0,"51.535",8791200000,23,"0.7542","0.338472","-0.405684","-2.05581","sp|P17066|HSP76_HUMAN;sp|P48741|HSP77_HUMAN","sp|P17066|HSP76_HUMAN;sp|P48741|HSP77_HUMAN",703,"P17066","HSP76_HUMAN","Heat shock 70 kDa protein 6",null,"HSPA6"]
["20.2361","20.4565","20.5833","20.9209",{"$nulls":9},1,1,1,60,60,60,"2.9471","0.00076161","2.9153",13152000,4,"0.740562","0.341424","-0.405827","-2.01308","tr|H0YLQ1|H0YLQ1_HUMAN;tr|H0YLF1|H0YLF1_HUMAN;tr|H0YLX7|H0YLX7_HUMAN;tr|H0YN03|H0YN03_HUMAN;tr|H0YNK2|H0YNK2_HUMAN;tr|H0YN21|H0YN21_HUMAN;tr|H0YMZ4|H0YMZ4_HUMAN;tr|H0YNT0|H0YNT0_HUMAN;tr|H0YN15|H0YN15_HUMAN;tr|H0YM56|H0YM56_HUMAN;tr|H0YLH4|H0YLH4_HUMAN;tr|H0YMF7|H0YMF7_HUMAN;tr|H0YL64|H0YL64_HUMAN;tr|H0YMN6|H0YMN6_HUMAN;tr|H0YL29|H0YL29_HUMAN;tr|H0YKR8|H0YKR8_HUMAN;tr|H0YLB2|H0YLB2_HUMAN;tr|H0YM86|H0YM86_HUMAN;tr|H0YNS2|H0YNS2_HUMAN;tr|H0YN92|H0YN92_HUMAN;sp|Q8TEB1|DCA11_HUMAN","tr|H0YLQ1|H0YLQ1_HUMAN;tr|H0YLF1|H0YLF1_HUMAN;tr|H0YLX7|H0YLX7_HUMAN;tr|H0YN03|H0YN03_HUMAN;tr|H0YNK2|H0YNK2_HUMAN;tr|H0YN21|H0YN21_HUMAN;tr|H0YMZ4|H0YMZ4_HUMAN;tr|H0YNT0|H0YNT0_HUMAN;tr|H0YN15|H0YN15_HUMAN;tr|H0YM56|H0YM56_HUMAN;tr|H0YLH4|H0YLH4_HUMAN;tr|H0YMF7|H0YMF7_HUMAN;tr|H0YL64|H0YL64_HUMAN;tr|H0YMN6|H0YMN6_HUMAN;tr|H0YL29|H0YL29_HUMAN;tr|H0YKR8|H0YKR8_HUMAN;tr|H0YLB2|H0YLB2_HUMAN;tr|H0YM86|H0YM86_HUMAN;tr|H0YNS2|H0YNS2_HUMAN;tr|H0YN92|H0YN92_HUMAN;sp|Q8TEB1|DCA11_HUMAN",2126,"H0YLQ1","H0YLQ1_HUMAN",null,null,"DCAF11"]
["25.7835","25.887","26.5488","25.9337",{"$nulls":9},1,1,1,"7.3","7.3","7.3","19.698","0.0011249","2.7986",12431000000,22,"0.4911","0.519884","-0.405951","-1.30167","tr|I3L191|I3L191_HUMAN;tr|A0A0C4DGH1|A0A0C4DGH1_HUMAN;sp|Q5XG92|EST4A_HUMAN","tr|I3L191|I3L191_HUMAN;tr|A0A0C4DGH1|A0A0C4DGH1_HUMAN;sp|Q5XG92|EST4A_HUMAN",1851,"I3L191","I3L191_HUMAN",null,null,"CES4A"]
["16.9548","16.7566","17.3891","17.1344",{"$nulls":9},5,5,5,"9.2","9.2","9.2","89.634",0,"13.92",79358000,9,"0.891934","0.300363","-0.406076","-2.51622","tr|F5H6A0|F5H6A0_HUMAN;tr|J3KP58|J3KP58_HUMAN;sp|P30622|CLIP1_HUMAN;tr|F5H1T5|F5H1T5_HUMAN;tr|F6VGP8|F6VGP8_HUMAN;tr|F5H367|F5H367_HUMAN;tr|F5H270|F5H270_HUMAN;tr|F5H0N7|F5H0N7_HUMAN","tr|F5H6A0|F5H6A0_HUMAN;tr|J3KP58|J3KP58_HUMAN;sp|P30622|CLIP1_HUMAN;tr|F5H1T5|F5H1T5_HUMAN;tr|F6VGP8|F6VGP8_HUMAN",876,"F5H6A0","F5H6A0_HUMAN",null,null,"CLIP1"]
["16.715","16.4633","17.5331","16.4586",{"$nulls":9},3,3,3,"3.4","3.4","3.4","113.95",0,"3.9956",57205000,4,"0.269309","0.756902","-0.406667","-0.736931","tr|G3V5V3|G3V5V3_HUMAN;sp|O60524|NEMF_HUMAN;tr|G3V4D9|G3V4D9_HUMAN;tr|G3V547|G3V547_HUMAN","tr|G3V5V3|G3V5V3_HUMAN;sp|O60524|NEMF_HUMAN;tr|G3V4D9|G3V4D9_HUMAN",292,"G3V5V3","G3V5V3_HUMAN",null,null,"NEMF"]
["17.9999","18.2783","19.1553","17.9369",{"$nulls":5},"mitochondrion",{"$nulls":3},2,2,2,"23.8","23.8","23.8","17.167","0.0010604","2.3359",38655000,8,"0.235288","0.789206","-0.406994","-0.65125","tr|E9PIQ7|E9PIQ7_HUMAN;sp|O00165|HAX1_HUMAN;tr|Q5VYD6|Q5VYD6_HUMAN","tr|E9PIQ7|E9PIQ7_HUMAN;sp|O00165|HAX1_HUMAN;tr|Q5VYD6|Q5VYD6_HUMAN",121,"E9PIQ7","E9PIQ7_HUMAN",null,null,"HAX1"]
["17.7172","17.8026","18.3598","17.9753",{"$nulls":3},"endocytosis;negative regulation of phosphatase activity","actin binding","actin filament;axon;early endosome;growth cone;membrane",{"$nulls":3},5,5,5,"7.1","7.1","7.1","133.63",0,"55.305",168190000,33,"0.758632","0.336595","-0.407655","-2.06979","sp|Q5T1M5|FKB15_HUMAN;tr|A0A0A0MT60|A0A0A0MT60_HUMAN;tr|X6RKW4|X6RKW4_HUMAN","sp|Q5T1M5|FKB15_HUMAN;tr|A0A0A0MT60|A0A0A0MT60_HUMAN",1830,"Q5T1M5","FKB15_HUMAN","FK506-binding protein 15","KBP-15","FKBP15"]
["21.3702","21.4003","21.5453","22.0422",{"$nulls":3},"cargo loading into COPII-coated vesicle;intracellular protein transport","GTP binding","COPII vesicle coat;endoplasmic reticulum;extracellular exosome;Golgi membrane","Legionellosis;Protein processing in endoplasmic reticulum",null,null,5,5,3,"32.8","32.8","23.2","22.367",0,"108.9",357430000,20,"0.615338","0.424769","-0.408456","-1.64109","sp|Q9NR31|SAR1A_HUMAN;tr|H0Y5E8|H0Y5E8_HUMAN;tr|X1WI22|X1WI22_HUMAN;tr|D6RAA2|D6RAA2_HUMAN;tr|Q5SQT8|Q5SQT8_HUMAN;tr|D6RDB2|D6RDB2_HUMAN","sp|Q9NR31|SAR1A_HUMAN;tr|H0Y5E8|H0Y5E8_HUMAN",2678,"Q9NR31","SAR1A_HUMAN","GTP-binding protein SAR1a",null,"SAR1A"]
["17.001","17.1228","17.6703","17.2708",{"$nulls":3},"coenzyme A biosynthetic process","ATP binding;pantothenate kinase activity","cytoplasm","Metabolic pathways;Pantothenate and CoA biosynthesis",null,null,3,3,3,"3.4","3.4","3.4","85.99",0,"34.889",70714000,7,"0.722252","0.355811","-0.408633","-1.95645","sp|Q9NVE7|PANK4_HUMAN;tr|H0YA26|H0YA26_HUMAN;tr|A0A0G2JR38|A0A0G2JR38_HUMAN;tr|E9PHT6|E9PHT6_HUMAN","sp|Q9NVE7|PANK4_HUMAN;tr|H0YA26|H0YA26_HUMAN;tr|A0A0G2JR38|A0A0G2JR38_HUMAN;tr|E9PHT6|E9PHT6_HUMAN",2720,"Q9NVE7","PANK4_HUMAN","Pantothenate kinase 4","PanK4","PANK4"]
["23.0695","23.0872","23.7494","23.225",{"$nulls":3},"neutrophil degranulation;protein transport;regulation of small GTPase mediated signal transduction;signal transduction;small GTPase mediated signal transduction","GTPase activator activity;Rab GDP-dissociation inhibitor activity;RNA binding;small GTPase binding","azurophil granule lumen;cytoplasm;cytosol;extracellular exosome;extracellular region;focal adhesion;Golgi apparatus;membrane;myelin sheath;secretory granule lumen;vesicle",{"$nulls":3},18,18,13,"55.7","55.7","41.1","50.663",0,"323.31",2805100000,122,"0.585834","0.451714","-0.408816","-1.55816","sp|P50395|GDIB_HUMAN;tr|Q5SX87|Q5SX87_HUMAN;tr|Q5SX86|Q5SX86_HUMAN;tr|V9GYF8|V9GYF8_HUMAN;tr|Q5SX90|Q5SX90_HUMAN;tr|V9GYJ7|V9GYJ7_HUMAN;tr|Q5SX91|Q5SX91_HUMAN","sp|P50395|GDIB_HUMAN;tr|Q5SX87|Q5SX87_HUMAN",1110,"P50395","GDIB_HUMAN","Rab GDP dissociation inhibitor beta","ab GDI beta","GDI2"]
["15.8013","15.6938","15.986","16.327",{"$nulls":3},"ceramide biosynthetic process;positive regulation of lipophagy;sphinganine biosynthetic process;sphingolipid biosynthetic process;sphingolipid metabolic process;sphingomyelin biosynthetic process;sphingosine biosynthetic process","pyridoxal phosphate binding;serine C-palmitoyltransferase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;serine C-palmitoyltransferase complex;SPOTS complex","Metabolic pathways;Sphingolipid metabolism;Sphingolipid signaling pathway",null,null,2,2,2,"3.8","3.8","3.8","52.743","0.00040096","3.3899",31491000,8,"0.825559","0.321516","-0.408937","-2.28745","sp|O15269|SPTC1_HUMAN","sp|O15269|SPTC1_HUMAN",209,"O15269","SPTC1_HUMAN","Serine palmitoyltransferase 1",null,"SPTLC1"]
["22.0297","22.1817","22.6755","22.355",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation","ATP binding","Arp2/3 protein complex",{"$nulls":3},9,9,9,"35.7","35.7","35.7","42.003",0,"61.831",894330000,53,"0.832242","0.31426","-0.409571","-2.30988","tr|B4DXW1|B4DXW1_HUMAN;sp|P61158|ARP3_HUMAN;tr|F8WDR7|F8WDR7_HUMAN;sp|Q9P1U1|ARP3B_HUMAN","tr|B4DXW1|B4DXW1_HUMAN;sp|P61158|ARP3_HUMAN",1259,"B4DXW1","B4DXW1_HUMAN",null,null,"ACTR3"]
["24.2876","24.3747","24.8469","24.6378",{"$nulls":3},"cell cycle arrest;cell proliferation;negative regulation of apoptotic process;negative regulation of transcription, DNA-templated;neutrophil degranulation;positive regulation of cell differentiation;regulation of translation;rRNA processing;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;RNA binding;ubiquitin protein ligase binding","azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleus",{"$nulls":3},15,15,15,"45.9","45.9","45.9","43.786",0,"323.31",4620900000,80,"1.16598","0.316583","-0.411216","-3.62938","sp|Q9UQ80|PA2G4_HUMAN;tr|F8VR77|F8VR77_HUMAN;tr|H0YIN7|H0YIN7_HUMAN;tr|F8W0A3|F8W0A3_HUMAN;tr|F8VZ69|F8VZ69_HUMAN","sp|Q9UQ80|PA2G4_HUMAN",2930,"Q9UQ80","PA2G4_HUMAN","Proliferation-associated protein 2G4",null,"PA2G4"]
["20.5371","20.5109","21.3067","20.5662",{"$nulls":3},"actin cytoskeleton reorganization;actin-mediated cell contraction;cilium assembly;establishment or maintenance of cell polarity;heterotypic cell-cell adhesion;outflow tract septum morphogenesis;regulation of cell shape;smooth muscle cell chemotaxis;sprouting angiogenesis;substrate adhesion-dependent cell spreading","actin binding;cadherin binding","cytoskeleton;cytosol;focal adhesion;plasma membrane;Z disc","Focal adhesion",null,null,6,6,6,"27.4","27.4","27.4","42.243",0,"73.997",348170000,38,"0.418516","0.598","-0.412424","-1.11317","sp|Q9NVD7|PARVA_HUMAN;tr|J3KNQ4|J3KNQ4_HUMAN;tr|E9PS97|E9PS97_HUMAN","sp|Q9NVD7|PARVA_HUMAN;tr|J3KNQ4|J3KNQ4_HUMAN;tr|E9PS97|E9PS97_HUMAN",2719,"Q9NVD7","PARVA_HUMAN","Alpha-parvin",null,"PARVA"]
["20.5962","20.9088","21.3715","20.9591",{"$nulls":3},"chaperone cofactor-dependent protein refolding;chaperone-mediated protein complex assembly;cyclooxygenase pathway;positive regulation of phosphorylation;positive regulation of telomerase activity;prostaglandin biosynthetic process;protein stabilization;regulation of cellular response to heat;signal transduction;telomerase holoenzyme complex assembly;telomere maintenance;telomere maintenance via telomerase;xenobiotic metabolic process","DNA polymerase binding;Hsp90 protein binding;prostaglandin-E synthase activity;telomerase activity;unfolded protein binding","chromosome, telomeric region;cytosol;extracellular exosome;nucleoplasm;nucleus;protein complex;telomerase holoenzyme complex","Arachidonic acid metabolism;Metabolic pathways",null,null,3,3,3,20,20,20,"18.697",0,"11.897",196120000,15,"0.599209","0.438122","-0.412807","-1.59556","sp|Q15185|TEBP_HUMAN;tr|B4DDC6|B4DDC6_HUMAN;tr|A0A087WYT3|A0A087WYT3_HUMAN","sp|Q15185|TEBP_HUMAN;tr|B4DDC6|B4DDC6_HUMAN;tr|A0A087WYT3|A0A087WYT3_HUMAN",1683,"Q15185","TEBP_HUMAN","Prostaglandin E synthase 3",null,"PTGES3"]
["13.8036","16.3302","14.4499","16.5108",{"$nulls":3},"DNA replication;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;nuclear pore complex assembly;nuclear pore organization;nucleocytoplasmic transport;positive regulation of mRNA splicing, via spliceosome;posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;RNA export from nucleus;sister chromatid cohesion;telomere tethering at nuclear periphery;tRNA export from nucleus;viral process;viral transcription","mRNA binding;nuclear localization sequence binding;nucleocytoplasmic transporter activity;promoter-specific chromatin binding;RNA binding;RNA polymerase II transcription coactivator activity;serine-type peptidase activity;structural constituent of nuclear pore;transporter activity","cytosol;host cell;intracellular membrane-bounded organelle;intracellular ribonucleoprotein complex;nuclear body;nuclear envelope;nuclear inclusion body;nuclear membrane;nuclear periphery;nuclear pore;nuclear pore cytoplasmic filaments;nuclear pore nuclear basket;nuclear pore outer ring;nucleoplasm","Influenza A;RNA transport",null,null,2,2,2,"1.4","1.4","1.4","197.58",0,"5.1396",60032000,8,"0.0843316","0.925612","-0.413397","-0.253576","sp|P52948|NUP98_HUMAN;tr|H0YEN4|H0YEN4_HUMAN","sp|P52948|NUP98_HUMAN;tr|H0YEN4|H0YEN4_HUMAN",1172,"P52948","NUP98_HUMAN","Nuclear pore complex protein Nup98-Nup96",null,"NUP98"]
["18.5782","17.9777","19.2477","18.1364",{"$nulls":3},"error-free translesion synthesis;Golgi organization;negative regulation of RIG-I signaling pathway;negative regulation of type I interferon production;retrograde protein transport, ER to cytosol;ubiquitin-dependent ERAD pathway;ubiquitin-dependent protein catabolic process","metal ion binding;ubiquitin binding;ubiquitin protein ligase binding","cytosol;endoplasmic reticulum;nuclear outer membrane-endoplasmic reticulum membrane network;nucleoplasm;nucleus;UFD1-NPL4 complex;VCP-NPL4-UFD1 AAA ATPase complex","Protein processing in endoplasmic reticulum",null,null,5,5,5,"15.8","15.8","15.8","68.119",0,"84.883",119030000,17,"0.237034","0.788788","-0.414083","-0.655661","sp|Q8TAT6|NPL4_HUMAN;tr|I3L283|I3L283_HUMAN;tr|I3L3I1|I3L3I1_HUMAN;tr|A0A0D9SFI9|A0A0D9SFI9_HUMAN;tr|I3L4U9|I3L4U9_HUMAN;tr|I3L281|I3L281_HUMAN","sp|Q8TAT6|NPL4_HUMAN",2108,"Q8TAT6","NPL4_HUMAN","Nuclear protein localization protein 4 homolog","rotein NPL4","NPLOC4"]
["22.8414","22.5999","23.2346","23.035",{"$nulls":3},"chaperone-mediated protein folding","FK506 binding;peptidyl-prolyl cis-trans isomerase activity;receptor activity;RNA binding","cytoplasm;nucleus",{"$nulls":3},4,4,4,"20.1","20.1","20.1","25.177",0,"15.134",762400000,8,"0.927313","0.296475","-0.414159","-2.64392","sp|Q00688|FKBP3_HUMAN;tr|G3V5F2|G3V5F2_HUMAN","sp|Q00688|FKBP3_HUMAN",1408,"Q00688","FKBP3_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP3","PIase FKBP3","FKBP3"]
["16.1366","16.2786","17.7977","15.4462",{"$nulls":9},1,1,1,"6.3","6.3","6.3","31.743","0.00039386","3.2385",8239800,2,"0.11999","0.903142","-0.414384","-0.351803","tr|G3V3Y1|G3V3Y1_HUMAN;sp|Q8N8N7|PTGR2_HUMAN","tr|G3V3Y1|G3V3Y1_HUMAN;sp|Q8N8N7|PTGR2_HUMAN",2066,"G3V3Y1","G3V3Y1_HUMAN"]
["20.2642","20.2808","20.9145","20.4593",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone",null,"mitochondrial matrix;mitochondrial respiratory chain complex I;mitochondrion",{"$nulls":3},4,4,4,"17.5","17.5","17.5","40.836",0,"16.231",243490000,23,"0.676928","0.382422","-0.414422","-1.81971","tr|A0A087WXC5|A0A087WXC5_HUMAN;sp|O95299|NDUAA_HUMAN;tr|E7ESZ7|E7ESZ7_HUMAN;tr|Q8N1B9|Q8N1B9_HUMAN;tr|C9J6X0|C9J6X0_HUMAN","tr|A0A087WXC5|A0A087WXC5_HUMAN;sp|O95299|NDUAA_HUMAN;tr|E7ESZ7|E7ESZ7_HUMAN;tr|Q8N1B9|Q8N1B9_HUMAN;tr|C9J6X0|C9J6X0_HUMAN",425,"A0A087WXC5","A0A087WXC5_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|PIRNR:PIRNR000543}",null,"NDUFA10"]
["21.6372","21.6455","21.9976","22.1141",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cellular response to nerve growth factor stimulus;centrosome localization;ER to Golgi vesicle-mediated transport;microtubule cytoskeleton organization;microtubule-based movement;protein homooligomerization;sister chromatid cohesion","ATP binding;dynein heavy chain binding;microtubule motor activity","centrosome;cytoplasmic dynein complex;cytosol;kinetochore;late endosome;lysosome;membrane;microtubule","Phagosome;Salmonella infection;Vasopressin-regulated water reabsorption",null,null,6,6,6,"18.7","18.7","18.7","54.099",0,"83.414",980870000,38,"1.71461","0.345503","-0.41449","-7.09492","sp|O43237|DC1L2_HUMAN;tr|J3KRI4|J3KRI4_HUMAN;tr|J3KRZ2|J3KRZ2_HUMAN","sp|O43237|DC1L2_HUMAN;tr|J3KRI4|J3KRI4_HUMAN;tr|J3KRZ2|J3KRZ2_HUMAN",234,"O43237","DC1L2_HUMAN","Cytoplasmic dynein 1 light intermediate chain 2",null,"DYNC1LI2"]
["22.0421","21.8049","22.7949","21.8825",{"$nulls":3},"neutrophil degranulation;plasma membrane to endosome transport;protein transport;regulation of endocytosis","GDP binding;GTP binding;GTPase activity","anchored component of synaptic vesicle membrane;azurophil granule membrane;early endosome;early endosome membrane;endocytic vesicle;extracellular exosome;lipid droplet;lysosomal membrane;melanosome;plasma membrane","Amoebiasis;Endocytosis;Phagosome;Ras signaling pathway;Tuberculosis;Vasopressin-regulated water reabsorption",null,null,5,5,4,"32.4","32.4","27.3","23.482",0,"70.522",627340000,37,"0.326704","0.705633","-0.415226","-0.88088","sp|P51148|RAB5C_HUMAN;tr|K7ENY4|K7ENY4_HUMAN;tr|K7ERI8|K7ERI8_HUMAN;tr|K7ERQ8|K7ERQ8_HUMAN;tr|F8VVK3|F8VVK3_HUMAN;tr|K7EIP6|K7EIP6_HUMAN","sp|P51148|RAB5C_HUMAN;tr|K7ENY4|K7ENY4_HUMAN;tr|K7ERI8|K7ERI8_HUMAN;tr|K7ERQ8|K7ERQ8_HUMAN",1130,"P51148","RAB5C_HUMAN","Ras-related protein Rab-5C",null,"RAB5C"]
["18.494","18.5536","19.2124","18.6668",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular signal transduction;protein phosphorylation;transcription initiation from RNA polymerase II promoter","ATP binding;protein homodimerization activity;protein serine/threonine kinase activity","cell cortex;cytosol;endomembrane system;lamellipodium;membrane;nucleoplasm",{"$nulls":3},3,3,3,"8.8","8.8","8.8","59.844",0,"21.075",85307000,7,"0.570387","0.46683","-0.415837","-1.51537","sp|Q9UHY1|NRBP_HUMAN;tr|F8W6G1|F8W6G1_HUMAN","sp|Q9UHY1|NRBP_HUMAN;tr|F8W6G1|F8W6G1_HUMAN",2842,"Q9UHY1","NRBP_HUMAN","Nuclear receptor-binding protein",null,"NRBP1"]
["19.3619","18.9303","19.6057","19.5183",{"$nulls":3},"mRNA 3'-end processing;mRNA polyadenylation;mRNA processing;mRNA splicing, via spliceosome;protein tetramerization;termination of RNA polymerase II transcription","AU-rich element binding;histone deacetylase binding;hydrolase activity;identical protein binding;mRNA binding;protein homodimerization activity;RNA binding","centrosome;microtubule organizing center;mRNA cleavage factor complex;nuclear body;nucleoplasm;nucleus;paraspeckles","mRNA surveillance pathway",null,null,2,2,2,"14.1","14.1","14.1","26.227",0,"4.699",89289000,12,"0.700159","0.365996","-0.415893","-1.8892","sp|O43809|CPSF5_HUMAN;tr|H3BV41|H3BV41_HUMAN;tr|H3BND3|H3BND3_HUMAN","sp|O43809|CPSF5_HUMAN;tr|H3BV41|H3BV41_HUMAN;tr|H3BND3|H3BND3_HUMAN",267,"O43809","CPSF5_HUMAN","Cleavage and polyadenylation specificity factor subunit 5",null,"NUDT21"]
["19.1784","19.1113","19.8754","19.2462",{"$nulls":3},"amyloid-beta clearance;amyloid-beta metabolic process;bradykinin catabolic process;determination of adult lifespan;hormone catabolic process;insulin catabolic process;insulin metabolic process;insulin receptor signaling pathway;negative regulation of proteolysis;positive regulation of protein catabolic process;positive regulation of protein oligomerization;protein heterooligomerization;protein homooligomerization;protein homotetramerization;proteolysis;proteolysis involved in cellular protein catabolic process;ubiquitin recycling","amyloid-beta binding;ATP binding;ATPase activity;beta-endorphin binding;identical protein binding;insulin binding;metalloendopeptidase activity;peptide binding;protein homodimerization activity;receptor binding;ubiquitin-dependent protein binding;virus receptor activity;zinc ion binding","cell surface;cytoplasm;cytosol;cytosolic proteasome complex;extracellular space;mitochondrion;nucleus;peroxisomal matrix;peroxisome;plasma membrane","Alzheimer disease",null,null,10,10,10,"12.7","12.7","12.7","117.97",0,"25.098",444410000,27,"0.496042","0.517619","-0.415971","-1.31473","sp|P14735|IDE_HUMAN;tr|Q5T5N3|Q5T5N3_HUMAN","sp|P14735|IDE_HUMAN",674,"P14735","IDE_HUMAN","Insulin-degrading enzyme",null,"IDE"]
["22.148","21.9578","22.9402","21.9987",{"$nulls":3},"apoptotic process;cell proliferation;protein import into nucleus","nuclear export signal receptor activity;Ran GTPase binding","cytoplasm;cytosol;extracellular exosome;membrane;nuclear envelope;nucleoplasm;nucleus",{"$nulls":3},26,26,26,"35.3","35.3","35.3","110.42",0,"323.31",2902800000,169,"0.321276","0.709172","-0.416496","-0.867259","sp|P55060|XPO2_HUMAN","sp|P55060|XPO2_HUMAN",1204,"P55060","XPO2_HUMAN","Exportin-2","xp2","CSE1L"]
["23.1824","23.0428","23.6853","23.374",{"$nulls":3},"activation of phospholipase D activity;apical protein localization;brain development;cell migration;dendritic spine development;epidermal growth factor receptor signaling pathway;ER to Golgi vesicle-mediated transport;establishment or maintenance of epithelial cell apical/basal polarity;learning;negative regulation of apoptotic process;positive regulation of transcription from RNA polymerase II promoter;protein ADP-ribosylation;protein localization to cilium;protein transport;regulation of reactive oxygen species metabolic process;response to axon injury;retrograde vesicle-mediated transport, Golgi to ER;small GTPase mediated signal transduction","ARF guanyl-nucleotide exchange factor activity;epidermal growth factor receptor binding;GTP binding;GTPase activity","cytosol;dendritic spine;extracellular exosome;extracellular matrix;Golgi apparatus;membrane;ruffle membrane",{"$nulls":3},4,3,3,"29.4","17.8","17.8","20.511",0,"33.769",1298200000,17,"0.871572","0.303446","-0.417002","-2.44459","sp|P18085|ARF4_HUMAN;tr|C9JAK5|C9JAK5_HUMAN;tr|U3KQF2|U3KQF2_HUMAN;tr|C9JPM4|C9JPM4_HUMAN","sp|P18085|ARF4_HUMAN;tr|C9JAK5|C9JAK5_HUMAN;tr|U3KQF2|U3KQF2_HUMAN;tr|C9JPM4|C9JPM4_HUMAN",718,"P18085","ARF4_HUMAN","ADP-ribosylation factor 4",null,"ARF4"]
["16.7054","16.3088","17.4858","16.3624",{"$nulls":3},"base-excision repair;cellular response to DNA damage stimulus;cellular response to UV;monoubiquitinated protein deubiquitination;negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of transcription, DNA-templated;positive regulation of canonical Wnt signaling pathway;positive regulation of cell growth;protein deubiquitination;response to drug;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitinyl hydrolase activity;WD40-repeat domain binding","cytoplasm;nucleoplasm;SCF ubiquitin ligase complex",{"$nulls":3},6,6,6,"6.7","6.7","6.7","157.31",0,"25.213",96026000,27,"0.254647","0.769172","-0.417019","-0.700071","sp|Q96K76|UBP47_HUMAN","sp|Q96K76|UBP47_HUMAN",2315,"Q96K76","UBP47_HUMAN","Ubiquitin carboxyl-terminal hydrolase 47",null,"USP47"]
["20.6906","20.3858","21.3308","20.5801",{"$nulls":3},"carbohydrate biosynthetic process;CMP-N-acetylneuraminate biosynthetic process","N-acetylneuraminate synthase activity;N-acylneuraminate cytidylyltransferase activity;N-acylneuraminate-9-phosphate synthase activity","cytoplasm;cytosol;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,4,4,4,"14.5","14.5","14.5","40.307",0,"19.757",276330000,15,"0.385898","0.633044","-0.417286","-1.03008","sp|Q9NR45|SIAS_HUMAN;tr|Q5TBR1|Q5TBR1_HUMAN;tr|Q5TBR0|Q5TBR0_HUMAN","sp|Q9NR45|SIAS_HUMAN;tr|Q5TBR1|Q5TBR1_HUMAN",2679,"Q9NR45","SIAS_HUMAN","Sialic acid synthase",null,"NANS"]
["17.6753","17.0572","18.3617","17.2073",{"$nulls":3},"phosphatidylinositol phosphorylation",{"$nulls":5},1,1,1,"19.8","19.8","19.8","12.921",0,"15.573",11934000,5,"0.230409","0.792959","-0.418318","-0.63891","tr|F8VRY7|F8VRY7_HUMAN;tr|F8VZG4|F8VZG4_HUMAN;tr|F8W1J0|F8W1J0_HUMAN;sp|O95861|BPNT1_HUMAN","tr|F8VRY7|F8VRY7_HUMAN;tr|F8VZG4|F8VZG4_HUMAN;tr|F8W1J0|F8W1J0_HUMAN;sp|O95861|BPNT1_HUMAN",455,"F8VRY7","F8VRY7_HUMAN",null,null,"BPNT1"]
["24.1497","24.7429","24.9628","24.7665",{"$nulls":3},"cellular response to insulin stimulus;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;membrane organization;negative regulation of protein kinase activity;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein targeting;regulation of G2/M transition of mitotic cell cycle;regulation of neuron differentiation;regulation of signal transduction;regulation of synaptic plasticity","identical protein binding;insulin-like growth factor receptor binding;protein domain specific binding;protein kinase C binding;protein kinase C inhibitor activity;receptor tyrosine kinase binding;RNA binding","cytoplasmic vesicle membrane;cytosol;extracellular exosome;focal adhesion;membrane;mitochondrion;myelin sheath","Cell cycle;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,11,6,6,"43.3","29.6","29.6","28.302",0,"266.75",4146600000,62,"0.505259","0.51421","-0.418391","-1.33917","sp|P61981|1433G_HUMAN","sp|P61981|1433G_HUMAN",1286,"P61981","1433G_HUMAN","14-3-3 protein gamma",null,"YWHAG"]
["20.3406","20.5232","21.0607","20.6408",{"$nulls":3},"cell cycle;cellular response to DNA damage stimulus;mitochondrial fragmentation involved in apoptotic process;mRNA processing;negative regulation of catalytic activity;negative regulation of cell growth;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of transcription, DNA-templated;positive regulation of apoptotic process;positive regulation of canonical Wnt signaling pathway;positive regulation of DNA damage checkpoint;regulation of cellular response to heat;regulation of circadian rhythm;regulation of DNA-templated transcription, elongation;regulation of protein deacetylation;regulation of protein stability;response to UV;rhythmic process;RNA splicing;transcription, DNA-templated;Wnt signaling pathway","enzyme binding;enzyme inhibitor activity;RNA binding;RNA polymerase II core binding","cytoplasm;DBIRD complex;mitochondrial matrix;nuclear chromatin;nucleoplasm;nucleus",{"$nulls":3},18,18,18,"32.2","32.2","32.2","102.9",0,"86.546",780050000,79,"0.680095","0.379003","-0.418818","-1.82912","sp|Q8N163|CCAR2_HUMAN;tr|G3V119|G3V119_HUMAN;tr|H0YB24|H0YB24_HUMAN;tr|E5RGU7|E5RGU7_HUMAN;tr|E5RFJ3|E5RFJ3_HUMAN;tr|E5RHJ4|E5RHJ4_HUMAN;tr|H0YC69|H0YC69_HUMAN;tr|H0YC58|H0YC58_HUMAN;tr|A0A087X2B6|A0A087X2B6_HUMAN;tr|E5RHH8|E5RHH8_HUMAN","sp|Q8N163|CCAR2_HUMAN;tr|G3V119|G3V119_HUMAN;tr|H0YB24|H0YB24_HUMAN",2033,"Q8N163","CCAR2_HUMAN","Cell cycle and apoptosis regulator protein 2",null,"CCAR2"]
["15.7527","15.4517","16.814","15.2293",{"$nulls":3},"cerebellar Purkinje cell layer development;glycosaminoglycan catabolic process;inner ear receptor cell development;locomotor rhythm;lysosome organization;middle ear morphogenesis;nervous system development;retinal rod cell development","alpha-N-acetylglucosaminidase activity","extracellular exosome;lysosomal lumen;lysosome","Glycosaminoglycan degradation;Lysosome;Metabolic pathways",null,null,2,2,2,"4.3","4.3","4.3","82.265","0.0011165","2.7662",19318000,2,"0.183881","0.83375","-0.419491","-0.520134","sp|P54802|ANAG_HUMAN","sp|P54802|ANAG_HUMAN",1196,"P54802","ANAG_HUMAN","Alpha-N-acetylglucosaminidase",null,"NAGLU"]
["21.0955","21.0878","21.4907","21.5327",{"$nulls":3},"epidermis development;lipid metabolic process;neutrophil degranulation;triglyceride catabolic process","fatty acid binding;lipid binding","azurophil granule lumen;cytoplasm;cytosol;extracellular exosome;extracellular region;nucleoplasm;plasma membrane;secretory granule membrane","PPAR signaling pathway",null,null,3,3,3,"21.5","21.5","21.5","15.164",0,"6.3811",193420000,8,"2.58896","0.5475","-0.420005","-19.6626","sp|Q01469|FABP5_HUMAN;tr|I6L8B7|I6L8B7_HUMAN","sp|Q01469|FABP5_HUMAN",1415,"Q01469","FABP5_HUMAN","Fatty acid-binding protein, epidermal",null,"FABP5"]
["17.5457","17.7994","18.012","18.1742",{"$nulls":3},"autophagy;cell junction assembly;cell-cell adhesion;embryo implantation;endoplasmic reticulum organization;exocytosis;Golgi organization",null,"autophagosome membrane;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment membrane;integral component of membrane;membrane;nucleolus;phagophore assembly site;plasma membrane","Autophagy - animal",null,null,2,2,2,"6.4","6.4","6.4","46.237",0,"9.7753",32078000,4,"0.967256","0.296054","-0.420532","-2.79325","sp|Q96GC9|VMP1_HUMAN;tr|K7EL93|K7EL93_HUMAN;tr|K7EL74|K7EL74_HUMAN;tr|K7ENU2|K7ENU2_HUMAN;tr|K7EK01|K7EK01_HUMAN;tr|K7EMI0|K7EMI0_HUMAN;tr|K7ELS2|K7ELS2_HUMAN;tr|K7EPE7|K7EPE7_HUMAN","sp|Q96GC9|VMP1_HUMAN;tr|K7EL93|K7EL93_HUMAN;tr|K7EL74|K7EL74_HUMAN;tr|K7ENU2|K7ENU2_HUMAN;tr|K7EK01|K7EK01_HUMAN;tr|K7EMI0|K7EMI0_HUMAN;tr|K7ELS2|K7ELS2_HUMAN;tr|K7EPE7|K7EPE7_HUMAN",2277,"Q96GC9","VMP1_HUMAN","Vacuole membrane protein 1",null,"VMP1"]
["21.1843","21.0476","21.6837","21.3899",{"$nulls":3},"actin filament bundle assembly;apoptotic process;apoptotic signaling pathway;interleukin-2 biosynthetic process;negative regulation of B cell proliferation;negative regulation of fibroblast proliferation;negative regulation of T cell proliferation;negative regulation of T cell receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;positive regulation of amyloid precursor protein biosynthetic process;positive regulation of apoptotic process;positive regulation of cellular senescence;positive regulation of gene expression;positive regulation of hydrogen peroxide-mediated programmed cell death;transcription, DNA-templated","actin binding;enzyme binding;leucine zipper domain binding;transcription corepressor activity","actin filament;cytoplasm;nuclear chromatin;nucleus",{"$nulls":3},4,4,4,"22.4","22.4","22.4","36.567",0,"38.532",334230000,23,"0.914727","0.292676","-0.420891","-2.59801","sp|Q96IZ0|PAWR_HUMAN;tr|A0A0B4J260|A0A0B4J260_HUMAN;tr|F8W1M8|F8W1M8_HUMAN;tr|H0YI16|H0YI16_HUMAN","sp|Q96IZ0|PAWR_HUMAN",2301,"Q96IZ0","PAWR_HUMAN","PRKC apoptosis WT1 regulator protein",null,"PAWR"]
["17.7092","17.3623","18.0004","17.9136",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;cell-cell signaling;female pregnancy;membrane organization;peptide catabolic process;protein catabolic process;protein polyubiquitination;proteolysis;regulation of blood pressure;signal transduction;SMAD protein signal transduction","aminopeptidase activity;metalloaminopeptidase activity;metallopeptidase activity;peptide binding;zinc ion binding","cytoplasmic vesicle membrane;cytosol;early endosome lumen;extracellular region;integral component of plasma membrane;intracellular;lysosomal membrane;membrane;perinuclear region of cytoplasm;plasma membrane","Renin-angiotensin system",null,null,5,5,5,"7.1","7.1","7.1","117.35",0,"32.408",95245000,20,"0.845801","0.308275","-0.42121","-2.35579","sp|Q9UIQ6|LCAP_HUMAN","sp|Q9UIQ6|LCAP_HUMAN",2851,"Q9UIQ6","LCAP_HUMAN","Leucyl-cystinyl aminopeptidase","ystinyl aminopeptidase","LNPEP"]
["19.0046","19.2604","19.8971","19.2115",{"$nulls":3},"mRNA processing;negative regulation of phosphatase activity","metal ion binding;RNA binding",{"$nulls":4},4,4,3,"5.3","5.3","4.1","113.6",0,"35.966",180420000,20,"0.43394","0.575839","-0.421777","-1.15277","sp|Q5T8P6|RBM26_HUMAN;tr|A0A087X0H9|A0A087X0H9_HUMAN","sp|Q5T8P6|RBM26_HUMAN;tr|A0A087X0H9|A0A087X0H9_HUMAN",1837,"Q5T8P6","RBM26_HUMAN","RNA-binding protein 26",null,"RBM26"]
["18.1392","18.4256","18.8574","18.5513",{"$nulls":9},1,1,1,"3.6","3.6","3.6","37.971",0,"6.8912",55248000,9,"0.740485","0.341038","-0.421936","-2.01284","tr|A0A0A0MRI1|A0A0A0MRI1_HUMAN;sp|Q8IXQ4|GPAM1_HUMAN","tr|A0A0A0MRI1|A0A0A0MRI1_HUMAN;sp|Q8IXQ4|GPAM1_HUMAN",2022,"A0A0A0MRI1","A0A0A0MRI1_HUMAN",null,null,"GPALPP1"]
["19.7718","19.8803","20.8839","19.6147",{"$nulls":3},"apoptotic process",null,"extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},3,3,3,"9.6","9.6","9.6","37.205",0,"10.695",177640000,12,"0.240577","0.785785","-0.423288","-0.66461","sp|Q9H3K2|GHITM_HUMAN;tr|Q9Y6G2|Q9Y6G2_HUMAN","sp|Q9H3K2|GHITM_HUMAN",2586,"Q9H3K2","GHITM_HUMAN","Growth hormone-inducible transmembrane protein",null,"GHITM"]
["17.0457","16.7546","17.4684","17.1796",{"$nulls":9},2,2,2,"20.1","20.1","20.1","34.437","0.0011169","2.7673",22310000,3,"0.757872","0.336204","-0.423869","-2.06739","tr|A0A0A0MSJ3|A0A0A0MSJ3_HUMAN;tr|Q3HKR1|Q3HKR1_HUMAN;tr|E9PFK9|E9PFK9_HUMAN;sp|Q9UJ41|RABX5_HUMAN","tr|A0A0A0MSJ3|A0A0A0MSJ3_HUMAN;tr|Q3HKR1|Q3HKR1_HUMAN;tr|E9PFK9|E9PFK9_HUMAN;sp|Q9UJ41|RABX5_HUMAN",2853,"A0A0A0MSJ3","A0A0A0MSJ3_HUMAN"]
["21.0218","20.9275","21.7806","21.0165",{"$nulls":3},"protein methylation;protein repair","cadherin binding;protein-L-isoaspartate (D-aspartate) O-methyltransferase activity","cytoplasm;cytosol;extracellular exosome;extracellular vesicle",{"$nulls":3},5,5,5,37,37,37,"24.636",0,"66.906",306140000,23,"0.413835","0.600005","-0.423875","-1.10119","sp|P22061|PIMT_HUMAN;tr|F6S8N6|F6S8N6_HUMAN;tr|A0A0A0MRJ6|A0A0A0MRJ6_HUMAN;tr|H7BY58|H7BY58_HUMAN;tr|C9J0F2|C9J0F2_HUMAN","sp|P22061|PIMT_HUMAN;tr|F6S8N6|F6S8N6_HUMAN;tr|A0A0A0MRJ6|A0A0A0MRJ6_HUMAN;tr|H7BY58|H7BY58_HUMAN",761,"P22061","PIMT_HUMAN","Protein-L-isoaspartate(D-aspartate) O-methyltransferase","IMT","PCMT1"]
["17.8735","18.4624","19.3495","17.8352",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;retrograde vesicle-mediated transport, Golgi to ER","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi membrane;transport vesicle",{"$nulls":3},8,7,7,"11.5","10.1","10.1","97.621",0,"62.169",192580000,25,"0.18476","0.835083","-0.424409","-0.522401","sp|Q9UBF2|COPG2_HUMAN","sp|Q9UBF2|COPG2_HUMAN",2800,"Q9UBF2","COPG2_HUMAN","Coatomer subunit gamma-2",null,"COPG2"]
["19.1905","18.783","19.538","19.2857",{"$nulls":3},"IRE1-mediated unfolded protein response;positive regulation of ATPase activity;protein folding","unfolded protein binding","endoplasmic reticulum;endoplasmic reticulum lumen;membrane","Protein processing in endoplasmic reticulum",null,null,3,3,3,"12.8","12.8","12.8","40.513",0,"9.0468",117360000,16,"0.661449","0.389269","-0.425104","-1.77407","sp|Q9UBS4|DJB11_HUMAN","sp|Q9UBS4|DJB11_HUMAN",2810,"Q9UBS4","DJB11_HUMAN","DnaJ homolog subfamily B member 11",null,"DNAJB11"]
["14.3502","14.1578","14.9082","14.4516",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;antigen processing and presentation, exogenous lipid antigen via MHC class Ib;blood coagulation;intracellular protein transport;melanosome organization;positive regulation of NK T cell differentiation;protein targeting to lysosome","GTP-dependent protein binding;protein phosphatase binding","AP-3 adaptor complex;axon cytoplasm;clathrin adaptor complex;clathrin-coated vesicle membrane;Golgi apparatus;lysosomal membrane;membrane","Lysosome",null,null,1,1,1,"1.8","1.8","1.8","121.32",0,"3.5662",11599000,3,"0.642594","0.400964","-0.425901","-1.71917","sp|O00203|AP3B1_HUMAN","sp|O00203|AP3B1_HUMAN",126,"O00203","AP3B1_HUMAN","AP-3 complex subunit beta-1",null,"AP3B1"]
["14.9283",1,"15.7823",1,{"$nulls":5},"cytosol;Golgi apparatus;Golgi cisterna membrane;perinuclear region of cytoplasm;trans-Golgi network",{"$nulls":3},1,1,1,"1.3","1.3","1.3","88.183","0.0075608","1.751",12015000,1,"0.013102","0.980508","-0.426987","-0.042046","sp|Q92805|GOGA1_HUMAN","sp|Q92805|GOGA1_HUMAN",2193,"Q92805","GOGA1_HUMAN","Golgin subfamily A member 1",null,"GOLGA1"]
["16.0697","15.9617","16.2094","16.6773",{"$nulls":3},"brain development;camera-type eye development;establishment of protein localization to endoplasmic reticulum membrane;excitatory postsynaptic potential;face morphogenesis;hypothalamus development;lipid particle organization;positive regulation of autophagosome assembly;positive regulation of endoplasmic reticulum tubular network organization;positive regulation of gene expression;positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization;positive regulation of GTPase activity;positive regulation of protein lipidation;regulation of calcium ion-dependent exocytosis of neurotransmitter;regulation of GTPase activity;regulation of short-term neuronal synaptic plasticity","GTPase activator activity;guanyl-nucleotide exchange factor activity;Rab GTPase binding","cytosol;endoplasmic reticulum membrane;endoplasmic reticulum tubular network;extracellular exosome;Golgi apparatus;lipid droplet;postsynapse;protein complex",{"$nulls":3},2,2,2,"2.1","2.1","2.1","110.52",0,"3.5127",41086000,6,"0.663856","0.389059","-0.427625","-1.78114","sp|Q15042|RB3GP_HUMAN","sp|Q15042|RB3GP_HUMAN",1666,"Q15042","RB3GP_HUMAN","Rab3 GTPase-activating protein catalytic subunit",null,"RAB3GAP1"]
["19.6642","19.5612","20.0872","19.9937",{"$nulls":3},"blood vessel development;brassinosteroid biosynthetic process;cell differentiation;cholesterol biosynthetic process;cholesterol biosynthetic process via desmosterol;cholesterol biosynthetic process via lathosterol;lung development;multicellular organism growth;post-embryonic development;regulation of cell proliferation;regulation of cholesterol biosynthetic process","7-dehydrocholesterol reductase activity;NADP binding;sterol delta7 reductase activity","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane;nuclear outer membrane","Metabolic pathways;Steroid biosynthesis",null,null,2,2,2,"4.4","4.4","4.4","54.489",0,"6.0835",144610000,13,"1.59432","0.339232","-0.427712","-6.14817","sp|Q9UBM7|DHCR7_HUMAN;tr|H0YE57|H0YE57_HUMAN","sp|Q9UBM7|DHCR7_HUMAN;tr|H0YE57|H0YE57_HUMAN",2802,"Q9UBM7","DHCR7_HUMAN","7-dehydrocholesterol reductase",{"$f":"-DHC reductase","v":{"$error":"#NAME?"}},"DHCR7"]
["16.0497","16.2373","17.0362","16.1073",{"$nulls":3},"cholesterol biosynthetic process;isopentenyl diphosphate biosynthetic process, mevalonate pathway;regulation of cholesterol biosynthetic process;response to cholesterol;sterol biosynthetic process","ATP binding;phosphomevalonate kinase activity","cytosol;extracellular exosome;membrane;peroxisome","Metabolic pathways;Peroxisome;Terpenoid backbone biosynthesis",null,null,1,1,1,"8.3","8.3","8.3","21.995","0.0010881","2.5236",10107000,2,"0.33584","0.696983","-0.428226","-0.903818","sp|Q15126|PMVK_HUMAN","sp|Q15126|PMVK_HUMAN",1678,"Q15126","PMVK_HUMAN","Phosphomevalonate kinase","MKase;PMK","PMVK"]
["20.1626","20.0836","20.5788","20.5247",{"$nulls":4},"metal ion binding",{"$nulls":4},4,4,4,"9.9","9.9","9.9","95.425",0,"156.93",278470000,20,"1.91125","0.392698","-0.428665","-8.94537","tr|M0QY97|M0QY97_HUMAN;sp|Q9UPT8|ZC3H4_HUMAN","tr|M0QY97|M0QY97_HUMAN;sp|Q9UPT8|ZC3H4_HUMAN",2924,"M0QY97","M0QY97_HUMAN",null,null,"ZC3H4"]
["16.4014","16.5213","17.2219","16.5585",{"$nulls":5},"cytosol;nucleoplasm;plasma membrane",{"$nulls":3},1,1,1,"5.3","5.3","5.3","36.156","0.00039984","3.3607",21823000,8,"0.479881","0.52507","-0.428805","-1.27215","tr|C9JK83|C9JK83_HUMAN;sp|O95630|STABP_HUMAN","tr|C9JK83|C9JK83_HUMAN;sp|O95630|STABP_HUMAN",442,"C9JK83","C9JK83_HUMAN",null,null,"STAMBP"]
["17.2318","16.9196","17.6333","17.3776",{"$nulls":3},"DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;NLS-bearing protein import into nucleus;protein import into nucleus, translocation;protein transport;ribosomal protein import into nucleus","nuclear localization sequence binding;protein transporter activity;Ran GTPase binding","cytoplasm;membrane;nuclear chromatin;nuclear membrane;nuclear periphery;protein complex",{"$nulls":3},4,4,4,"6.1","6.1","6.1","118.71",0,"5.7651",101850000,10,"0.777529","0.336756","-0.429716","-2.13001","sp|Q8TEX9|IPO4_HUMAN;tr|H0YN14|H0YN14_HUMAN;tr|H0YN07|H0YN07_HUMAN;tr|H0YMR4|H0YMR4_HUMAN","sp|Q8TEX9|IPO4_HUMAN;tr|H0YN14|H0YN14_HUMAN;tr|H0YN07|H0YN07_HUMAN;tr|H0YMR4|H0YMR4_HUMAN",2130,"Q8TEX9","IPO4_HUMAN","Importin-4","mp4","IPO4"]
["17.1975","17.2414","17.9631","17.3356",{"$nulls":3},"glycogen catabolic process;neutrophil degranulation","glycogen phosphorylase activity;linear malto-oligosaccharide phosphorylase activity;pyridoxal phosphate binding;SHG alpha-glucan phosphorylase activity","azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;membrane","Glucagon signaling pathway;Insulin resistance;Insulin signaling pathway;Metabolic pathways;Necroptosis;Starch and sucrose metabolism",null,null,6,4,4,"10.1","7.7","7.7","96.695",0,"50.686",95035000,20,"0.515697","0.510185","-0.429921","-1.36698","sp|P11216|PYGB_HUMAN;tr|H0Y4Z6|H0Y4Z6_HUMAN;sp|P11217|PYGM_HUMAN","sp|P11216|PYGB_HUMAN",623,"P11216","PYGB_HUMAN","Glycogen phosphorylase, brain form {ECO:0000303|PubMed:3346228}",null,"PYGB"]
["17.8591","17.4576","18.1252","18.0518",{"$nulls":9},2,2,2,"13.6","13.6","13.6","23.28","0.0010901","2.5338",31624000,8,"0.770581","0.338517","-0.430161","-2.10776","tr|F2Z2Y8|F2Z2Y8_HUMAN;sp|Q9H0E2|TOLIP_HUMAN;tr|E9PNS3|E9PNS3_HUMAN;tr|E7EN89|E7EN89_HUMAN","tr|F2Z2Y8|F2Z2Y8_HUMAN;sp|Q9H0E2|TOLIP_HUMAN;tr|E9PNS3|E9PNS3_HUMAN;tr|E7EN89|E7EN89_HUMAN",2558,"F2Z2Y8","F2Z2Y8_HUMAN",null,null,"TOLLIP"]
["23.1663","22.719","23.4321","23.3138",{"$nulls":3},"cellular response to arsenic-containing substance;glutathione derivative biosynthetic process;glutathione metabolic process;interleukin-12-mediated signaling pathway;L-ascorbic acid metabolic process;methylation;negative regulation of ryanodine-sensitive calcium-release channel activity;positive regulation of ryanodine-sensitive calcium-release channel activity;positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;toxin catabolic process;xenobiotic catabolic process","glutathione dehydrogenase (ascorbate) activity;glutathione transferase activity;methylarsonate reductase activity;oxidoreductase activity","cytoplasm;cytosol;extracellular exosome","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Fluid shear stress and atherosclerosis;Glutathione metabolism;Hepatocellular carcinoma;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pathways in cancer;Platinum drug resistance",null,null,7,7,7,"26.6","26.6","26.6","27.566",0,"25.178",1284800000,36,"0.690406","0.374332","-0.430284","-1.85988","sp|P78417|GSTO1_HUMAN;tr|Q5TA02|Q5TA02_HUMAN;tr|Q5TA01|Q5TA01_HUMAN","sp|P78417|GSTO1_HUMAN;tr|Q5TA02|Q5TA02_HUMAN",1372,"P78417","GSTO1_HUMAN","Glutathione S-transferase omega-1","STO-1","GSTO1"]
["21.3959","20.7163","21.4051","21.5679",{"$nulls":3},"cholesterol biosynthetic process;farnesyl diphosphate biosynthetic process;geranyl diphosphate biosynthetic process;regulation of cholesterol biosynthetic process;viral process","dimethylallyltranstransferase activity;geranyltranstransferase activity;metal ion binding;RNA binding","cytoplasm;cytosol;mitochondrion;nucleoplasm","Human T-cell leukemia virus 1 infection;Influenza A;Metabolic pathways;Terpenoid backbone biosynthesis",null,null,3,3,3,"9.1","9.1","9.1","48.275",0,"15.885",585980000,11,"0.464445","0.5379","-0.43039","-1.23178","sp|P14324|FPPS_HUMAN;tr|A0A087X1D8|A0A087X1D8_HUMAN;tr|A0A087WVN4|A0A087WVN4_HUMAN;tr|A0A087WTP2|A0A087WTP2_HUMAN;tr|A0A087X090|A0A087X090_HUMAN","sp|P14324|FPPS_HUMAN;tr|A0A087X1D8|A0A087X1D8_HUMAN;tr|A0A087WVN4|A0A087WVN4_HUMAN",667,"P14324","FPPS_HUMAN","Farnesyl pyrophosphate synthase","PP synthase;PS","FDPS"]
["19.8977","19.8694","20.5856","20.0431",{"$nulls":3},"regulation of translation","translation initiation factor activity",{"$nulls":4},6,6,6,"12.6","12.6","12.6","64.449",0,"33.718",281930000,50,"0.595833","0.441146","-0.430816","-1.58609","tr|F8WAE5|F8WAE5_HUMAN;sp|Q9BY44|EIF2A_HUMAN;tr|H7C5R5|H7C5R5_HUMAN;tr|C9IZE1|C9IZE1_HUMAN","tr|F8WAE5|F8WAE5_HUMAN;sp|Q9BY44|EIF2A_HUMAN",2506,"F8WAE5","F8WAE5_HUMAN","Eukaryotic translation initiation factor 2A {ECO:0000256|PIRNR:PIRNR017222}","IF-2A {ECO:0000256|PIRNR:PIRNR017222}","EIF2A"]
["20.1694","20.217","20.7237","20.5247",{"$nulls":3},"nucleotide-sugar biosynthetic process","coenzyme binding;oxidoreductase activity",{"$nulls":4},3,3,3,"16.8","16.8","16.8","29.666",0,"8.233",158330000,15,"1.28402","0.327625","-0.430976","-4.21249","tr|E9PKL9|E9PKL9_HUMAN;sp|Q13630|FCL_HUMAN;tr|E9PLH9|E9PLH9_HUMAN;tr|E9PP14|E9PP14_HUMAN;tr|A0A0J9YX13|A0A0J9YX13_HUMAN;tr|E9PP60|E9PP60_HUMAN","tr|E9PKL9|E9PKL9_HUMAN;sp|Q13630|FCL_HUMAN;tr|E9PLH9|E9PLH9_HUMAN;tr|E9PP14|E9PP14_HUMAN;tr|A0A0J9YX13|A0A0J9YX13_HUMAN",1581,"E9PKL9","E9PKL9_HUMAN",null,null,"TSTA3"]
["15.9864","15.1977","16.1148","15.9314",{"$nulls":4},"long-chain fatty acid-CoA ligase activity;nucleotide binding;very long-chain fatty acid-CoA ligase activity","endoplasmic reticulum;integral component of membrane;membrane;mitochondrial membrane","Insulin resistance",null,null,1,1,1,"3.3","3.3","3.3","78.643",0,"6.3097",13635000,7,"0.399526","0.62155","-0.431057","-1.0647","sp|Q5K4L6|S27A3_HUMAN;tr|X6R3N0|X6R3N0_HUMAN","sp|Q5K4L6|S27A3_HUMAN;tr|X6R3N0|X6R3N0_HUMAN",1818,"Q5K4L6","S27A3_HUMAN","Long-chain fatty acid transport protein 3","ATP-3;atty acid transport protein 3","SLC27A3"]
["20.4302","20.1015","20.7075","20.6865",{"$nulls":3},"mRNA splicing, via spliceosome","snRNA stem-loop binding;snRNP binding;U1 snRNA binding","catalytic step 2 spliceosome;fibrillar center;nuclear speck;nucleoplasm;spliceosomal complex;U1 snRNP;U2 snRNP","Spliceosome",null,null,1,1,1,"4.4","4.4","4.4","25.486","0.0010691","2.3855",143770000,6,"0.920187","0.293387","-0.431163","-2.61786","sp|P08579|RU2B_HUMAN","sp|P08579|RU2B_HUMAN",565,"P08579","RU2B_HUMAN","U2 small nuclear ribonucleoprotein B''","2 snRNP B''","SNRPB2"]
["19.1583",1,"20.0207",1,{"$nulls":3},"tRNA aminoacylation for protein translation","aminoacyl-tRNA ligase activity;ATP binding;nucleic acid binding",{"$nulls":4},1,1,1,5,5,5,"27.205",0,"5.0693",47620000,0,"0.0101862","0.983321","-0.431169","-0.0327927","tr|E9PRK2|E9PRK2_HUMAN;sp|Q96I59|SYNM_HUMAN","tr|E9PRK2|E9PRK2_HUMAN;sp|Q96I59|SYNM_HUMAN",2295,"E9PRK2","E9PRK2_HUMAN",null,null,"NARS2"]
["19.8689","19.9989","20.471","20.2595",{"$nulls":3},"cardiovascular system development;cell differentiation;cell redox homeostasis;negative regulation of protein ubiquitination;negative regulation of Wnt signaling pathway;Wnt signaling pathway","protein-disulfide reductase activity;thioredoxin-disulfide reductase activity","cytoplasm;cytosol;nucleus",{"$nulls":3},7,7,7,"23.9","23.9","23.9","48.392",0,"68.76",342060000,25,"1.13205","0.311136","-0.431306","-3.47454","sp|Q6DKJ4|NXN_HUMAN;tr|A0A0G2JQK5|A0A0G2JQK5_HUMAN;tr|I3L4V6|I3L4V6_HUMAN;tr|A0A0C4DGI2|A0A0C4DGI2_HUMAN","sp|Q6DKJ4|NXN_HUMAN",1864,"Q6DKJ4","NXN_HUMAN","Nucleoredoxin",null,"NXN"]
["18.7438","18.4187","19.3193","18.7064",{"$nulls":3},"cholesterol metabolic process;negative regulation of cholesterol biosynthetic process;negative regulation of fatty acid biosynthetic process;SREBP signaling pathway;transmembrane transport;ubiquitin-dependent ERAD pathway","cholesterol binding;ubiquitin protein ligase binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;protein complex",{"$nulls":3},3,1,1,11,4,4,"38.925","0.0010834","2.4897",83811000,5,"0.469152","0.534157","-0.431596","-1.24406","sp|O75477|ERLN1_HUMAN","sp|O75477|ERLN1_HUMAN",348,"O75477","ERLN1_HUMAN","Erlin-1",null,"ERLIN1"]
["15.384","15.6797","16.2622","15.6659",{"$nulls":3},"spermatid development;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","DNA binding transcription factor activity","fibrillar center;nucleoplasm;nucleus;transcription elongation factor complex;transcriptionally active chromatin",{"$nulls":3},2,2,2,"2.7","2.7","2.7","127.46",0,"6.7458",29165000,11,"0.489939","0.521861","-0.432177","-1.29861","sp|Q9UHB7|AFF4_HUMAN","sp|Q9UHB7|AFF4_HUMAN",2827,"Q9UHB7","AFF4_HUMAN","AF4/FMR2 family member 4",null,"AFF4"]
["16.025","16.5392","16.669","16.7601",{"$nulls":5},"Golgi apparatus",{"$nulls":3},3,3,3,"5.6","5.6","5.6","89.847",0,"4.3888",50945000,8,"0.6207","0.422421","-0.432442","-1.65633","tr|H7BY83|H7BY83_HUMAN;sp|Q5JSH3|WDR44_HUMAN","tr|H7BY83|H7BY83_HUMAN;sp|Q5JSH3|WDR44_HUMAN",1812,"H7BY83","H7BY83_HUMAN",null,null,"WDR44"]
["20.8266","20.6695","21.6454","20.7179",{"$nulls":5},"cytosol;nucleoplasm;proteasome activator complex",{"$nulls":3},4,4,4,"21.6","21.6","21.6","26.867",0,"17.627",277030000,17,"0.343044","0.691552","-0.433618","-0.921919","tr|K9J957|K9J957_HUMAN;sp|P61289|PSME3_HUMAN;tr|A0A087WTV2|A0A087WTV2_HUMAN;tr|K7ENH2|K7ENH2_HUMAN;tr|B3KQ25|B3KQ25_HUMAN;tr|K7ESG5|K7ESG5_HUMAN;tr|K7EMD0|K7EMD0_HUMAN;tr|K7EPX6|K7EPX6_HUMAN;tr|K7EKR3|K7EKR3_HUMAN;tr|B7Z8D3|B7Z8D3_HUMAN","tr|K9J957|K9J957_HUMAN;sp|P61289|PSME3_HUMAN;tr|A0A087WTV2|A0A087WTV2_HUMAN;tr|K7ENH2|K7ENH2_HUMAN;tr|B3KQ25|B3KQ25_HUMAN;tr|K7ESG5|K7ESG5_HUMAN",1268,"K9J957","K9J957_HUMAN",null,null,"PSME3"]
["19.7252","19.6958","20.3502","19.9383",{"$nulls":3},"protein N-linked glycosylation via asparagine","transferase activity, transferring glycosyl groups","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},5,5,5,15,15,15,"48.799",0,"14.246",241470000,23,"0.768451","0.337693","-0.433805","-2.10097","tr|A0A0C4DGS1|A0A0C4DGS1_HUMAN;sp|P39656|OST48_HUMAN;tr|U3KQ84|U3KQ84_HUMAN","tr|A0A0C4DGS1|A0A0C4DGS1_HUMAN;sp|P39656|OST48_HUMAN",964,"A0A0C4DGS1","A0A0C4DGS1_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit {ECO:0000256|RuleBase:RU361142}","ligosaccharyl transferase 48 kDa subunit {ECO:0000256|RuleBase:RU361142}","DDOST"]
["16.6301","16.3863","17.4149","16.4699",{"$nulls":3},"signal transduction",{"$nulls":5},1,1,1,6,6,6,"24.362","0.0010631","2.3532",13477000,3,"0.330242","0.702876","-0.43416","-0.88976","tr|Q68DZ5|Q68DZ5_HUMAN;sp|P32121|ARRB2_HUMAN","tr|Q68DZ5|Q68DZ5_HUMAN;sp|P32121|ARRB2_HUMAN",902,"Q68DZ5","Q68DZ5_HUMAN",null,null,"DKFZp686L0365"]
["20.9018","21.2922","21.1993","21.8632",{"$nulls":3},"actin cytoskeleton organization","actin filament binding","actin cytoskeleton",{"$nulls":3},3,3,3,10,10,10,"41.603",0,"13.797",362650000,21,"0.424212","0.59075","-0.434274","-1.12777","tr|B4E3S0|B4E3S0_HUMAN;sp|Q9ULV4|COR1C_HUMAN;tr|H0YHL7|H0YHL7_HUMAN","tr|B4E3S0|B4E3S0_HUMAN;sp|Q9ULV4|COR1C_HUMAN;tr|H0YHL7|H0YHL7_HUMAN",2897,"B4E3S0","B4E3S0_HUMAN","Coronin {ECO:0000256|RuleBase:RU280818}",null,"CORO1C"]
["22.0329","22.454","22.3327","23.0237",{"$nulls":3},"autophagy;COPII vesicle coating;ER to Golgi vesicle-mediated transport;positive regulation of glycoprotein metabolic process;post-translational protein modification;protein transport;regulation of autophagosome assembly;retrograde vesicle-mediated transport, Golgi to ER;virion assembly","GTP binding;GTPase activity","cytosol;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;Golgi apparatus;Golgi membrane;mitochondrion;phagophore assembly site membrane;transport vesicle","Legionellosis",null,null,7,7,2,"48.8","48.8","15.9","22.171",0,"71.384",894240000,48,"0.403406","0.617731","-0.434794","-1.07458","sp|Q9H0U4|RAB1B_HUMAN;tr|E9PLD0|E9PLD0_HUMAN;tr|A0A087WTI1|A0A087WTI1_HUMAN;sp|Q92928|RAB1C_HUMAN","sp|Q9H0U4|RAB1B_HUMAN;tr|E9PLD0|E9PLD0_HUMAN",2563,"Q9H0U4","RAB1B_HUMAN","Ras-related protein Rab-1B",null,"RAB1B"]
["18.0319","16.7989","18.6382","17.0628",{"$nulls":3},"cellular iron ion homeostasis;heme catabolic process;heme oxidation;iron ion homeostasis;neutrophil degranulation;response to hypoxia;response to oxidative stress","heme binding;heme oxygenase (decyclizing) activity;metal ion binding","endoplasmic reticulum membrane;membrane;plasma membrane;specific granule membrane","Metabolic pathways;Mineral absorption;Porphyrin and chlorophyll metabolism",null,null,3,3,3,19,19,19,"36.032",0,"141.03",48073000,11,"0.151186","0.876168","-0.435103","-0.434978","sp|P30519|HMOX2_HUMAN;tr|I3L159|I3L159_HUMAN;tr|I3L1F5|I3L1F5_HUMAN;tr|A0A087WT44|A0A087WT44_HUMAN;tr|I3L276|I3L276_HUMAN;tr|I3L1Y2|I3L1Y2_HUMAN;tr|I3L4P8|I3L4P8_HUMAN;tr|A0A0K0K1G7|A0A0K0K1G7_HUMAN;tr|I3L463|I3L463_HUMAN","sp|P30519|HMOX2_HUMAN;tr|I3L159|I3L159_HUMAN;tr|I3L1F5|I3L1F5_HUMAN;tr|A0A087WT44|A0A087WT44_HUMAN",872,"P30519","HMOX2_HUMAN","Heme oxygenase 2","O-2","HMOX2"]
["21.6648","21.4089","22.0321","21.9124",{"$nulls":3},"cellular response to growth factor stimulus;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;muscle contraction;muscle organ development;negative regulation of catenin import into nucleus;negative regulation of fibroblast proliferation;positive regulation of protein export from nucleus;regulation of canonical Wnt signaling pathway;skeletal muscle cell differentiation","actin binding;beta-tubulin binding;cadherin binding","cytoplasm;endoplasmic reticulum;integral component of membrane;membrane;microtubule;nuclear envelope;nuclear inner membrane;nuclear membrane;nuclear outer membrane;nucleoplasm","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM)",null,null,7,7,7,"46.5","46.5","46.5","28.994",0,"49.344",408680000,30,"1.04062","0.298863","-0.435425","-3.08291","sp|P50402|EMD_HUMAN;tr|Q5HY57|Q5HY57_HUMAN","sp|P50402|EMD_HUMAN;tr|Q5HY57|Q5HY57_HUMAN",1111,"P50402","EMD_HUMAN","Emerin",null,"EMD"]
["20.9465","20.9051","21.4657","21.2578",{"$nulls":3},"protein transport;regulation of ER to Golgi vesicle-mediated transport;vesicle-mediated transport",null,"COPII-coated ER to Golgi transport vesicle;endoplasmic reticulum;endoplasmic reticulum exit site;endoplasmic reticulum membrane;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},1,1,1,"4.7","4.7","4.7","27.989","0.00039667","3.3124",51153000,9,"1.26479","0.325349","-0.435938","-4.11253","sp|Q969M3|YIPF5_HUMAN","sp|Q969M3|YIPF5_HUMAN",2219,"Q969M3","YIPF5_HUMAN","Protein YIPF5",null,"YIPF5"]
["19.4204","19.188","20.0446","19.4364",{"$nulls":3},"actin cytoskeleton organization;activation of GTPase activity;cell chemotaxis;G-protein coupled receptor signaling pathway;neutrophil degranulation;platelet activation;positive regulation of cell proliferation;positive regulation of protein localization to plasma membrane;positive regulation of transcription, DNA-templated;Rac protein signal transduction;regulation of ruffle assembly;regulation of small GTPase mediated signal transduction;Rho protein signal transduction","GTP binding;GTPase activity","cytosol;endoplasmic reticulum membrane;extracellular exosome;focal adhesion;plasma membrane;secretory granule membrane","Bacterial invasion of epithelial cells;Salmonella infection;Shigellosis",null,null,2,2,2,"18.8","18.8","18.8","21.308",0,"8.4148",91299000,13,"0.505685","0.514614","-0.436303","-1.3403","sp|P84095|RHOG_HUMAN","sp|P84095|RHOG_HUMAN",1391,"P84095","RHOG_HUMAN","Rho-related GTP-binding protein RhoG",null,"RHOG"]
["17.6991","17.453","18.517","17.5087",{"$nulls":3},"exocytosis",null,"exocyst",{"$nulls":3},1,1,1,14,14,14,"13.927",0,"5.4296",18042000,9,"0.311047","0.71499","-0.436786","-0.841607","tr|C9JME6|C9JME6_HUMAN;tr|C9JKC2|C9JKC2_HUMAN;tr|B5MCY9|B5MCY9_HUMAN;tr|K7ERQ5|K7ERQ5_HUMAN;tr|A0A0A0MRE1|A0A0A0MRE1_HUMAN;tr|B4DJ07|B4DJ07_HUMAN;tr|A0A0A0MSB8|A0A0A0MSB8_HUMAN;sp|Q9UPT5|EXOC7_HUMAN","tr|C9JME6|C9JME6_HUMAN;tr|C9JKC2|C9JKC2_HUMAN;tr|B5MCY9|B5MCY9_HUMAN;tr|K7ERQ5|K7ERQ5_HUMAN;tr|A0A0A0MRE1|A0A0A0MRE1_HUMAN;tr|B4DJ07|B4DJ07_HUMAN;tr|A0A0A0MSB8|A0A0A0MSB8_HUMAN;sp|Q9UPT5|EXOC7_HUMAN",2923,"C9JME6","C9JME6_HUMAN",null,null,"EXOC7"]
["20.3975","20.3645","21.3624","20.2734",{"$nulls":3},"COPI coating of Golgi vesicle;ER to Golgi vesicle-mediated transport;Golgi organization;positive regulation of organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER","syntaxin binding","endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of membrane;trans-Golgi network transport vesicle;transport vesicle",{"$nulls":3},1,1,1,"4.7","4.7","4.7","27.277",0,"110.96",220900000,8,"0.295274","0.733441","-0.436905","-0.802068","sp|Q9BVK6|TMED9_HUMAN","sp|Q9BVK6|TMED9_HUMAN",2473,"Q9BVK6","TMED9_HUMAN","Transmembrane emp24 domain-containing protein 9",null,"TMED9"]
["19.4001","19.1558","20.0133","19.4165",{"$nulls":3},"microtubule-based process;mitotic cell cycle","microtubule binding","cytoplasm;membrane;microtubule;microtubule cytoskeleton","Non-small cell lung cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer",null,null,7,7,7,"11.3","11.3","11.3","108.91",0,"37.387",353250000,22,"0.511313","0.511866","-0.436964","-1.35528","sp|Q9HC35|EMAL4_HUMAN;tr|B5MBZ0|B5MBZ0_HUMAN","sp|Q9HC35|EMAL4_HUMAN;tr|B5MBZ0|B5MBZ0_HUMAN",2640,"Q9HC35","EMAL4_HUMAN","Echinoderm microtubule-associated protein-like 4","MAP-4","EML4"]
["22.2527","21.3203","22.2196","22.2274",{"$nulls":3},"actin filament depolymerization;actin filament fragmentation;actin filament severing;actin polymerization or depolymerization;positive regulation of actin filament depolymerization","actin filament binding","actin cytoskeleton;cortical actin cytoskeleton;extracellular exosome",{"$nulls":3},4,4,4,"29.7","29.7","29.7","18.506",0,"11.17",473750000,14,"0.349152","0.687585","-0.43702","-0.937283","sp|P60981|DEST_HUMAN;tr|F6RFD5|F6RFD5_HUMAN","sp|P60981|DEST_HUMAN;tr|F6RFD5|F6RFD5_HUMAN",1247,"P60981","DEST_HUMAN","Destrin",null,"DSTN"]
["17.3819","17.567","17.9343","17.8889",{"$nulls":3},"apoptotic process;central nervous system development;Fc-gamma receptor signaling pathway involved in phagocytosis;positive regulation of actin filament polymerization;positive regulation of Arp2/3 complex-mediated actin nucleation;positive regulation of lamellipodium assembly;Rac protein signal transduction;vascular endothelial growth factor receptor signaling pathway;viral process","protein complex binding","cytosol;extracellular exosome;filamentous actin;focal adhesion;integral component of membrane;lamellipodium;lamellipodium membrane;ruffle;SCAR complex","Regulation of actin cytoskeleton",null,null,4,4,4,"4.7","4.7","4.7","128.79",0,"34.578",133910000,15,"1.35285","0.335491","-0.437163","-4.58761","sp|Q9Y2A7|NCKP1_HUMAN","sp|Q9Y2A7|NCKP1_HUMAN",2948,"Q9Y2A7","NCKP1_HUMAN","Nck-associated protein 1","AP 1","NCKAP1"]
["21.1277","20.8959","21.9164","20.982",{"$nulls":3},"GTP metabolic process;immune response;positive regulation of mRNA catabolic process;signal transduction","GTP binding;GTPase activity;RNA binding","cytoplasmic exosome (RNase complex);cytosol;membrane",{"$nulls":3},3,3,3,6,6,6,"72.453",0,"9.1097",762190000,17,"0.337745","0.698616","-0.437411","-0.908603","sp|O00178|GTPB1_HUMAN;tr|F5H716|F5H716_HUMAN;tr|B0QY59|B0QY59_HUMAN","sp|O00178|GTPB1_HUMAN",123,"O00178","GTPB1_HUMAN","GTP-binding protein 1","P1;P-1;-protein 1","GTPBP1"]
["19.1358","19.0553","19.8662","19.2",{"$nulls":4},"RNA binding","mRNA cleavage factor complex",{"$nulls":3},2,2,2,11,11,11,"24.387","0.00075959","2.8993",61334000,5,"0.492051","0.519168","-0.437569","-1.30419","tr|F5H6M0|F5H6M0_HUMAN;tr|F5H047|F5H047_HUMAN;tr|F5H669|F5H669_HUMAN;sp|Q8N684|CPSF7_HUMAN;tr|J3QT54|J3QT54_HUMAN","tr|F5H6M0|F5H6M0_HUMAN;tr|F5H047|F5H047_HUMAN;tr|F5H669|F5H669_HUMAN;sp|Q8N684|CPSF7_HUMAN;tr|J3QT54|J3QT54_HUMAN",2060,"F5H6M0","F5H6M0_HUMAN",null,null,"CPSF7"]
["15.3652","14.8728","15.2296","15.8837",{"$nulls":3},"activation of protein kinase activity;apoptotic process;B cell proliferation;cell chemotaxis;cell cycle;cellular response to angiotensin;cellular response to hydrogen peroxide;cellular response to hydroperoxide;cellular senescence;defense response to bacterium;execution phase of apoptosis;Fc-gamma receptor signaling pathway involved in phagocytosis;histone phosphorylation;immunoglobulin mediated immune response;interferon-gamma-mediated signaling pathway;interleukin-10 production;interleukin-12 production;intrinsic apoptotic signaling pathway in response to oxidative stress;negative regulation of actin filament polymerization;negative regulation of filopodium assembly;negative regulation of glial cell apoptotic process;negative regulation of inflammatory response;negative regulation of insulin receptor signaling pathway;negative regulation of MAP kinase activity;negative regulation of peptidyl-tyrosine phosphorylation;negative regulation of platelet aggregation;negative regulation of protein binding;neutrophil activation;neutrophil degranulation;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;platelet activation;positive regulation of apoptotic signaling pathway;positive regulation of ceramide biosynthetic process;positive regulation of endodeoxyribonuclease activity;positive regulation of glucosylceramide catabolic process;positive regulation of phospholipid scramblase activity;positive regulation of protein dephosphorylation;positive regulation of protein import into nucleus;positive regulation of response to DNA damage stimulus;positive regulation of sphingomyelin catabolic process;positive regulation of superoxide anion generation;protein phosphorylation;protein stabilization;regulation of actin cytoskeleton organization;regulation of mRNA stability;regulation of receptor activity;signal transduction;stimulatory C-type lectin receptor signaling pathway;termination of signal transduction","ATP binding;calcium-independent protein kinase C activity;enzyme activator activity;enzyme binding;insulin receptor substrate binding;kinase binding;metal ion binding;non-membrane spanning protein tyrosine kinase activity;protein kinase activity;protein kinase binding;protein kinase C activity;protein serine/threonine kinase activity","azurophil granule lumen;cell-cell junction;cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;extracellular region;nuclear matrix;nucleoplasm;nucleus;perinuclear region of cytoplasm;plasma membrane","AGE-RAGE signaling pathway in diabetic complications;Autophagy - animal;Chemokine signaling pathway;C-type lectin receptor signaling pathway;Estrogen signaling pathway;Fc gamma R-mediated phagocytosis;GnRH signaling pathway;Inflammatory mediator regulation of TRP channels;Insulin resistance;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Type II diabetes mellitus;Vascular smooth muscle contraction",null,null,1,1,1,"2.5","2.5","2.5","77.504",0,"3.8081",16750000,8,"0.40128","0.621437","-0.437669","-1.06916","sp|Q05655|KPCD_HUMAN","sp|Q05655|KPCD_HUMAN",1454,"Q05655","KPCD_HUMAN","Protein kinase C delta type",null,"PRKCD"]
["17.7966","17.4353","18.3351","17.7722",{"$nulls":3},"developmental cell growth;hematopoietic stem cell proliferation;multicellular organism development;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein targeting to mitochondrion;protein K48-linked ubiquitination;protein K63-linked ubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process","ubiquitin conjugating enzyme binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity;zinc ion binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"5.3","5.3","5.3","57.818",0,"34.526",61062000,9,"0.493775","0.51949","-0.4377","-1.30874","sp|O95376|ARI2_HUMAN","sp|O95376|ARI2_HUMAN",430,"O95376","ARI2_HUMAN","E3 ubiquitin-protein ligase ARIH2","RI-2;rotein ariadne-2 homolog","ARIH2"]
["21.1456","21.1551","21.734","21.4427",{"$nulls":3},"attachment of spindle microtubules to kinetochore;cell division;microtubule bundle formation;microtubule polymerization;mitotic sister chromatid segregation;mitotic spindle assembly;mitotic spindle assembly checkpoint;protein stabilization;regulation of chromosome segregation;regulation of transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;heparin binding;microtubule binding;RNA binding;zinc ion binding","condensed chromosome kinetochore;cytoplasm;kinetochore;microtubule;nucleolus;nucleoplasm;nucleus;spindle;spindle matrix",{"$nulls":3},4,4,4,"11.3","11.3","11.3","50.75",0,"58.033",326700000,22,"1.0215","0.296582","-0.437952","-3.00543","sp|O43670|ZN207_HUMAN;tr|J3QRS9|J3QRS9_HUMAN;tr|X6R4W8|X6R4W8_HUMAN;tr|J3QS27|J3QS27_HUMAN;tr|J3KTL1|J3KTL1_HUMAN;tr|J3KRB6|J3KRB6_HUMAN;tr|J3KRW6|J3KRW6_HUMAN;tr|H0Y3M2|H0Y3M2_HUMAN;tr|J3KS31|J3KS31_HUMAN","sp|O43670|ZN207_HUMAN;tr|J3QRS9|J3QRS9_HUMAN;tr|X6R4W8|X6R4W8_HUMAN;tr|J3QS27|J3QS27_HUMAN;tr|J3KTL1|J3KTL1_HUMAN;tr|J3KRB6|J3KRB6_HUMAN;tr|J3KRW6|J3KRW6_HUMAN;tr|H0Y3M2|H0Y3M2_HUMAN;tr|J3KS31|J3KS31_HUMAN",255,"O43670","ZN207_HUMAN","BUB3-interacting and GLEBS motif-containing protein ZNF207 {ECO:0000303|PubMed:24462186, ECO:0000303|PubMed:24462187}","BuGZ {ECO:0000303|PubMed:26388440};uGZ {ECO:0000303|PubMed:24462186, ECO:0000303|PubMed:24462187}","ZNF207"]
["15.8309","15.7135","16.8692","15.5513",{"$nulls":5},"extracellular exosome;membrane",{"$nulls":3},5,5,5,"4.1","4.1","4.1","224.3",0,"13.587",71333000,15,"0.239577","0.787166","-0.438018","-0.662086","sp|Q9P2D3|HTR5B_HUMAN","sp|Q9P2D3|HTR5B_HUMAN",2785,"Q9P2D3","HTR5B_HUMAN","HEAT repeat-containing protein 5B",null,"HEATR5B"]
["20.2967","20.19","20.9828","20.3807",{"$nulls":3},"activation of innate immune response;innate immune response;mRNA splicing, via spliceosome;negative regulation of transcription, DNA-templated;regulation of circadian rhythm;regulation of transcription, DNA-templated;rhythmic process;transcription, DNA-templated","core promoter binding;RNA binding;transcription regulatory region sequence-specific DNA binding","cytoplasm;fibrillar center;nuclear matrix;nuclear speck;nucleoplasm;nucleus;paraspeckles",{"$nulls":3},7,7,7,"23.1","23.1","23.1","58.743",0,"33.025",243760000,22,"0.540529","0.486897","-0.438376","-1.43378","sp|Q8WXF1|PSPC1_HUMAN;tr|X6RDA4|X6RDA4_HUMAN","sp|Q8WXF1|PSPC1_HUMAN;tr|X6RDA4|X6RDA4_HUMAN",2155,"Q8WXF1","PSPC1_HUMAN","Paraspeckle component 1",null,"PSPC1"]
["16.8766","17.2584","18.2656","16.747",{"$nulls":3},"receptor-mediated endocytosis;vesicle docking involved in exocytosis",null,"cytosol;endosome;endosome membrane;trans-Golgi network membrane;transport vesicle",{"$nulls":3},2,2,2,"6.7","6.7","6.7","40.564",0,"4.5328",30140000,3,"0.199582","0.82095","-0.438813","-0.560474","sp|Q7Z6M1|RABEK_HUMAN;tr|Q5T1S4|Q5T1S4_HUMAN;tr|Q5T1S5|Q5T1S5_HUMAN","sp|Q7Z6M1|RABEK_HUMAN;tr|Q5T1S4|Q5T1S4_HUMAN;tr|Q5T1S5|Q5T1S5_HUMAN",1963,"Q7Z6M1","RABEK_HUMAN","Rab9 effector protein with kelch motifs",null,"RABEPK"]
["19.0286","19.1681","19.7493","19.3255",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},3,3,3,"31.4","31.4","31.4","13.669",0,"6.1632",46393000,14,"0.726023","0.35123","-0.439067","-1.96805","tr|H7C2P7|H7C2P7_HUMAN;sp|Q16540|RM23_HUMAN;tr|A6NJD9|A6NJD9_HUMAN;tr|A8MVT4|A8MVT4_HUMAN;tr|A8MYK1|A8MYK1_HUMAN","tr|H7C2P7|H7C2P7_HUMAN;sp|Q16540|RM23_HUMAN;tr|A6NJD9|A6NJD9_HUMAN;tr|A8MVT4|A8MVT4_HUMAN;tr|A8MYK1|A8MYK1_HUMAN",1741,"H7C2P7","H7C2P7_HUMAN",null,null,"MRPL23"]
["22.2667","22.3266","22.5585","22.9136",{"$nulls":3},"cellular response to interleukin-4;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal large subunit assembly;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","5S rRNA binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;nucleolus;nucleus;protein complex","Ribosome",null,null,7,7,7,"17.1","17.1","17.1","46.108",0,"47.218",1306700000,49,"0.870279","0.304124","-0.439398","-2.44008","sp|P39023|RL3_HUMAN;tr|G5E9G0|G5E9G0_HUMAN;tr|B5MCW2|B5MCW2_HUMAN;tr|H7C3M2|H7C3M2_HUMAN;tr|H7C422|H7C422_HUMAN;tr|F8WCR1|F8WCR1_HUMAN","sp|P39023|RL3_HUMAN;tr|G5E9G0|G5E9G0_HUMAN;tr|B5MCW2|B5MCW2_HUMAN",962,"P39023","RL3_HUMAN","60S ribosomal protein L3",null,"RPL3"]
["17.2202","17.308","18.1117","17.2954",{"$nulls":3},"actin polymerization or depolymerization","protein tyrosine kinase activator activity",{"$nulls":4},2,2,2,"6.6","6.6","6.6","43.294","0.0037607","2.0506",31567000,2,"0.401858","0.620591","-0.439462","-1.07063","tr|B6VEX4|B6VEX4_HUMAN;tr|A0A0A0MRT6|A0A0A0MRT6_HUMAN;sp|Q8IZP0|ABI1_HUMAN","tr|B6VEX4|B6VEX4_HUMAN;tr|A0A0A0MRT6|A0A0A0MRT6_HUMAN;sp|Q8IZP0|ABI1_HUMAN",2030,"B6VEX4","B6VEX4_HUMAN",null,null,"ABI1"]
["15.7917","16.0709","16.7309","16.0118",{"$nulls":3},"endoplasmic reticulum membrane fusion;Golgi reassembly;mitotic cell cycle;protein deubiquitination;protein K11-linked deubiquitination;protein K48-linked deubiquitination;protein ubiquitination","thiol-dependent ubiquitin-specific protease activity","cytoplasm;endoplasmic reticulum lumen;Golgi stack",{"$nulls":3},2,2,2,"2.5","2.5","2.5","134.32",0,"17.979",52223000,11,"0.429374","0.584028","-0.440068","-1.14102","sp|Q96JH7|VCIP1_HUMAN","sp|Q96JH7|VCIP1_HUMAN",2306,"Q96JH7","VCIP1_HUMAN","Deubiquitinating protein VCIP135",null,"VCPIP1"]
["20.1939","19.4455","20.4478","20.0721",{"$nulls":3},"metabolic process","catalytic activity",{"$nulls":4},2,2,2,"10.3","10.3","10.3","24.704",0,"4.2765",93255000,6,"0.394324","0.624107","-0.440233","-1.05147","tr|H3BS70|H3BS70_HUMAN;tr|Q96DC0|Q96DC0_HUMAN;sp|P42126|ECI1_HUMAN","tr|H3BS70|H3BS70_HUMAN;tr|Q96DC0|Q96DC0_HUMAN;sp|P42126|ECI1_HUMAN",989,"H3BS70","H3BS70_HUMAN",null,null,"ECI1"]
["18.5801","18.7997","19.4495","18.8109",{"$nulls":3},"cellular calcium ion homeostasis;Golgi calcium ion transport;protein N-linked glycosylation;regulation of lysosomal lumen pH",null,"early endosome membrane;endosome membrane;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;late endosome membrane;lysosomal membrane;trans-Golgi network membrane",{"$nulls":3},4,4,4,"19.4","19.4","19.4","34.905",0,"9.0352",81479000,19,"0.492053","0.519565","-0.440325","-1.30419","sp|Q9HC07|TM165_HUMAN;tr|V9GY93|V9GY93_HUMAN;tr|D6RBL0|D6RBL0_HUMAN;tr|D6RD79|D6RD79_HUMAN","sp|Q9HC07|TM165_HUMAN;tr|V9GY93|V9GY93_HUMAN",2639,"Q9HC07","TM165_HUMAN","Transmembrane protein 165",null,"TMEM165"]
["18.1592","17.8056","18.889","17.9564",{"$nulls":3},"cellular response to insulin stimulus;positive regulation by host of viral transcription;positive regulation of angiogenesis;positive regulation of blood vessel endothelial cell migration;positive regulation of gene expression;positive regulation of hydrogen sulfide biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of vascular endothelial cell proliferation;regulation of cholesterol biosynthetic process;regulation of phenotypic switching by transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;rhythmic process;snRNA transcription from RNA polymerase II promoter;viral process","bHLH transcription factor binding;core promoter sequence-specific DNA binding;DNA binding;DNA binding transcription factor activity;double-stranded DNA binding;histone acetyltransferase binding;histone deacetylase binding;HMG box domain binding;metal ion binding;protein C-terminus binding;protein homodimerization activity;repressing transcription factor binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;RNA polymerase II repressing transcription factor binding;sequence-specific DNA binding;transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcription factor binding;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytoplasm;nuclear chromatin;nucleoplasm;nucleus;protein-DNA complex;transcriptional repressor complex","Breast cancer;Choline metabolism in cancer;Cortisol synthesis and secretion;Cushing syndrome;Endocrine resistance;Estrogen signaling pathway;Human cytomegalovirus infection;Huntington disease;Mitophagy - animal;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;TGF-beta signaling pathway;Transcriptional misregulation in cancer",null,null,1,1,1,"3.6","3.6","3.6","80.692","0.0014065","2.3085",28510000,8,"0.327545","0.704954","-0.440351","-0.88299","sp|P08047|SP1_HUMAN","sp|P08047|SP1_HUMAN",554,"P08047","SP1_HUMAN","Transcription factor Sp1",null,"SP1"]
["19.1742","18.2009","19.2279","19.0285",{"$nulls":3},"actin filament depolymerization;actin filament fragmentation;muscle cell cellular homeostasis;positive regulation of actin filament depolymerization;sarcomere organization;skeletal muscle tissue development","actin filament binding","actin cytoskeleton;extracellular exosome;extracellular space;I band;nuclear matrix;Z disc","Axon guidance;Fc gamma R-mediated phagocytosis;Human immunodeficiency virus 1 infection;Pertussis;Regulation of actin cytoskeleton",null,null,5,2,2,"34.3","17.5","17.5","18.736",0,"42.243",46872000,11,"0.329156","0.703978","-0.440626","-0.887033","sp|Q9Y281|COF2_HUMAN;tr|F8WDN3|F8WDN3_HUMAN","sp|Q9Y281|COF2_HUMAN",2944,"Q9Y281","COF2_HUMAN","Cofilin-2",null,"CFL2"]
["22.8713","22.3683","23.2777","22.844",{"$nulls":3},"activation-induced cell death of T cells;erythrocyte development;G1/S transition of mitotic cell cycle;gastrulation;glucose homeostasis;mitotic cell cycle checkpoint;negative regulation of apoptotic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;oogenesis stage;placenta development;positive regulation of apoptotic process;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;T cell differentiation in thymus;T cell proliferation involved in immune response;TOR signaling;translation;translational initiation;viral transcription","protein kinase binding;RNA binding;structural constituent of ribosome","cell body;cytoplasmic ribonucleoprotein granule;cytosol;cytosolic small ribosomal subunit;dendrite;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;polysome;small ribosomal subunit","Apelin signaling pathway;EGFR tyrosine kinase inhibitor resistance;HIF-1 signaling pathway;Insulin signaling pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;Proteoglycans in cancer;Ribosome;Thermogenesis",null,null,5,5,5,"19.3","19.3","19.3","28.68",0,"25.219",646460000,14,"0.501174","0.513713","-0.441072","-1.32832","sp|P62753|RS6_HUMAN;tr|A2A3R7|A2A3R7_HUMAN;tr|A2A3R5|A2A3R5_HUMAN","sp|P62753|RS6_HUMAN;tr|A2A3R7|A2A3R7_HUMAN",1312,"P62753","RS6_HUMAN","40S ribosomal protein S6",null,"RPS6"]
["15.5137","16.8826","17.5316","15.7469",{"$nulls":3},"mRNA 3'-end processing;mRNA cleavage;mRNA polyadenylation;mRNA splicing, via spliceosome;termination of RNA polymerase II transcription","mRNA binding;RNA binding","nucleoplasm;nucleus","mRNA surveillance pathway",null,null,2,2,2,"3.5","3.5","3.5","82.921",0,"5.9712",30812000,5,"0.135051","0.894333","-0.441116","-0.392231","sp|Q12996|CSTF3_HUMAN","sp|Q12996|CSTF3_HUMAN",1511,"Q12996","CSTF3_HUMAN","Cleavage stimulation factor subunit 3",null,"CSTF3"]
["18.9023","19.0608","19.7741","19.0712",{"$nulls":3},"3'-UTR-mediated mRNA destabilization;cell cycle phase transition;cellular response to interleukin-1;cellular response to lipopolysaccharide;DNA repair;DNA replication;dosage compensation by inactivation of X chromosome;histone mRNA catabolic process;mRNA export from nucleus;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of mRNA catabolic process;regulation of telomere maintenance;regulation of translational termination;telomere maintenance via semi-conservative replication","ATP binding;ATP-dependent RNA helicase activity;chromatin binding;helicase activity;RNA binding;telomeric DNA binding;zinc ion binding","chromatin;cytoplasm;cytosol;exon-exon junction complex;nuclear chromosome, telomeric region;nucleoplasm;nucleus;P-body;supraspliceosomal complex","mRNA surveillance pathway;RNA transport",null,null,9,9,9,"11.1","11.1","11.1","124.34",0,"72.255",387590000,32,"0.461658","0.54154","-0.441131","-1.22452","sp|Q92900|RENT1_HUMAN","sp|Q92900|RENT1_HUMAN",2201,"Q92900","RENT1_HUMAN","Regulator of nonsense transcripts 1",null,"UPF1"]
["22.1784","22.1202","22.7267","22.4563",{"$nulls":3},"aging;cardiac muscle cell differentiation;cellular response to calcium ion;cellular response to leukemia inhibitory factor;negative regulation of cell death;positive regulation of DNA replication;response to growth hormone","protein domain specific binding;protein homodimerization activity;ubiquitin protein ligase binding","beta-catenin destruction complex;cell body;cytosol;extracellular exosome;neuron projection;nuclear envelope lumen;nucleoplasm;SCF ubiquitin ligase complex","Wnt signaling pathway",null,null,6,6,6,"28.1","28.1","28.1","26.21",0,"35.112",788060000,34,"1.06841","0.302986","-0.442198","-3.19817","sp|Q9HB71|CYBP_HUMAN;tr|B2ZWH1|B2ZWH1_HUMAN","sp|Q9HB71|CYBP_HUMAN",2634,"Q9HB71","CYBP_HUMAN","Calcyclin-binding protein","acyBP;CacyBP","CACYBP"]
["16.0578","16.3474","16.6439","16.6458",{"$nulls":3},"mitochondrial alanyl-tRNA aminoacylation;mitochondrial respiratory chain complex assembly;tRNA modification","alanine-tRNA ligase activity;amino acid binding;ATP binding;metal ion binding;tRNA binding","mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,2,2,2,"2.7","2.7","2.7","107.34",0,"4.4996",43678000,7,"1.03351","0.299154","-0.442233","-3.0539","sp|Q5JTZ9|SYAM_HUMAN","sp|Q5JTZ9|SYAM_HUMAN",1816,"Q5JTZ9","SYAM_HUMAN","Alanine--tRNA ligase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03133}",null,"AARS2"]
["21.8599","21.3812","22.2941","21.8319",{"$nulls":3},"actin filament fragmentation;apical junction assembly;cortical cytoskeleton organization;establishment of planar polarity of follicular epithelium;locomotion;maintenance of epithelial cell apical/basal polarity;neutrophil mediated immunity;neutrophil migration;platelet degranulation;platelet formation;positive regulation of actin filament depolymerization;regulation of actin filament depolymerization;regulation of cell shape;regulation of oligodendrocyte differentiation;regulation of ventricular cardiac muscle cell membrane repolarization;sarcomere organization;sensory perception of sound","actin filament binding","actomyosin, actin portion;cell projection;cell-cell junction;cortical actin cytoskeleton;cytosol;extracellular exosome;extracellular region;myelin sheath;podosome",{"$nulls":3},13,13,13,"28.5","28.5","28.5","66.193",0,"41.949",1272300000,62,"0.50177","0.512821","-0.442454","-1.3299","sp|O75083|WDR1_HUMAN;tr|D6RD66|D6RD66_HUMAN","sp|O75083|WDR1_HUMAN;tr|D6RD66|D6RD66_HUMAN",317,"O75083","WDR1_HUMAN","WD repeat-containing protein 1",null,"WDR1"]
["17.9837","17.5756","19.008","17.4367",{"$nulls":3},"protein N-linked glycosylation via asparagine","ADP-ribose diphosphatase activity;identical protein binding;metal ion binding;UDP-sugar diphosphatase activity","cytosol;extracellular exosome",{"$nulls":3},2,2,2,"12.2","12.2","12.2","24.118","0.0075858","1.7643",23420000,2,"0.193701","0.828376","-0.442706","-0.5454","sp|O95848|NUD14_HUMAN","sp|O95848|NUD14_HUMAN",454,"O95848","NUD14_HUMAN","Uridine diphosphate glucose pyrophosphatase","DPG pyrophosphatase;GPPase","NUDT14"]
["18.1947","17.4689","18.8911","17.658",{"$nulls":5},"integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},20,3,0,"40.2","7.7",0,"73.253",0,"20.856",122100000,19,"0.22249","0.800764","-0.442738","-0.618841","tr|C9J406|C9J406_HUMAN;tr|H7C463|H7C463_HUMAN","tr|C9J406|C9J406_HUMAN;tr|H7C463|H7C463_HUMAN",3074,"C9J406","C9J406_HUMAN","MICOS complex subunit MIC60 {ECO:0000256|RuleBase:RU363000}",null,"IMMT"]
["21.3121","21.0111","21.9422","21.2665",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway",null,"cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nuclear proteasome complex;nucleoplasm;proteasome accessory complex;proteasome complex;proteasome regulatory particle;proteasome regulatory particle, lid subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,12,12,12,"30.7","30.7","30.7","52.904",0,"33.169",798940000,49,"0.451123","0.551886","-0.442772","-1.19715","sp|O00232|PSD12_HUMAN;tr|J3KTJ5|J3KTJ5_HUMAN;tr|J3KSK1|J3KSK1_HUMAN","sp|O00232|PSD12_HUMAN",128,"O00232","PSD12_HUMAN","26S proteasome non-ATPase regulatory subunit 12",null,"PSMD12"]
["24.0509","23.695","24.5026","24.1294",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;defense response to Gram-negative bacterium;erythrocyte differentiation;killing of cells of other organism;maturation of SSU-rRNA;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);monocyte chemotaxis;negative regulation of respiratory burst involved in inflammatory response;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleolus organization;positive regulation of cellular component movement;positive regulation of respiratory burst involved in inflammatory response;protein tetramerization;response to extracellular stimulus;ribosomal small subunit assembly;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","fibroblast growth factor binding;protein homodimerization activity;protein kinase binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleolus;nucleoplasm;ribosome","Ribosome",null,null,7,7,7,"42.1","42.1","42.1","16.06",0,"36.789",1941500000,25,"0.642295","0.401631","-0.443054","-1.71831","sp|P39019|RS19_HUMAN;tr|A0A075B6E2|A0A075B6E2_HUMAN;tr|M0R2L9|M0R2L9_HUMAN;tr|M0QXK4|M0QXK4_HUMAN;tr|M0QYF7|M0QYF7_HUMAN;tr|M0R140|M0R140_HUMAN","sp|P39019|RS19_HUMAN;tr|A0A075B6E2|A0A075B6E2_HUMAN",961,"P39019","RS19_HUMAN","40S ribosomal protein S19",null,"RPS19"]
["17.1059","16.959","17.383","17.5692",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"11.7","11.7","11.7","17.442",0,"4.1019",14267000,3,"1.18951","0.321931","-0.443597","-3.73998","tr|Q5VZJ2|Q5VZJ2_HUMAN;sp|Q76EJ3|S35D2_HUMAN","tr|Q5VZJ2|Q5VZJ2_HUMAN;sp|Q76EJ3|S35D2_HUMAN",1926,"Q5VZJ2","Q5VZJ2_HUMAN",null,null,"SLC35D2"]
["17.0868","16.7208","17.6014","17.0948",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;clathrin-dependent endocytosis;ephrin receptor signaling pathway;intracellular protein transport;low-density lipoprotein particle clearance;low-density lipoprotein particle receptor catabolic process;membrane organization;microtubule-based movement;neutrophil degranulation;regulation of defense response to virus by virus;Wnt signaling pathway, planar cell polarity pathway","disordered domain specific binding;lipid binding;protein kinase binding;protein transporter activity","AP-2 adaptor complex;clathrin-coated endocytic vesicle;clathrin-coated endocytic vesicle membrane;cytoplasmic vesicle;cytosol;endocytic vesicle membrane;endolysosome membrane;ficolin-1-rich granule membrane;plasma membrane;secretory granule membrane","Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Huntington disease;Synaptic vesicle cycle",null,null,10,5,5,"14.2","8.1","8.1","103.96",0,"10.77",78821000,20,"0.536051","0.492916","-0.444273","-1.42167","sp|O94973|AP2A2_HUMAN;tr|A0A0G2JS82|A0A0G2JS82_HUMAN;tr|A0A0G2JQM1|A0A0G2JQM1_HUMAN","sp|O94973|AP2A2_HUMAN;tr|A0A0G2JS82|A0A0G2JS82_HUMAN;tr|A0A0G2JQM1|A0A0G2JQM1_HUMAN",405,"O94973","AP2A2_HUMAN","AP-2 complex subunit alpha-2",null,"AP2A2"]
["18.1469","18.258","18.7708","18.5229",{"$nulls":5},"integral component of membrane;mitochondrion",{"$nulls":3},1,1,1,"5.4","5.4","5.4","45.811",0,"5.9377",63638000,6,"1.08585","0.306793","-0.444405","-3.27216","sp|Q96ER9|CCD51_HUMAN","sp|Q96ER9|CCD51_HUMAN",2264,"Q96ER9","CCD51_HUMAN","Coiled-coil domain-containing protein 51",null,"CCDC51"]
["20.6093","19.7647","20.7743","20.4888",{"$nulls":3},"galactose catabolic process;gluconeogenesis;glucose metabolic process;glycogen biosynthetic process;glycogen catabolic process;glycolytic process;neutrophil degranulation","magnesium ion binding;phosphoglucomutase activity","actin cytoskeleton;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;tertiary granule lumen","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways;Pentose phosphate pathway;Purine metabolism;Starch and sucrose metabolism",null,null,6,6,6,"13.9","13.9","13.9","61.448",0,"80.472",478000000,42,"0.372916","0.652375","-0.444541","-0.997211","sp|P36871|PGM1_HUMAN","sp|P36871|PGM1_HUMAN",948,"P36871","PGM1_HUMAN","Phosphoglucomutase-1","GM 1","PGM1"]
["17.3598","17.13","17.8803","17.499",{"$nulls":9},1,1,1,4,4,4,"35.153","0.00039888","3.3441",20021000,4,"0.735612","0.34818","-0.444721","-1.99769","tr|Q69YM1|Q69YM1_HUMAN;sp|A2RU67|K1467_HUMAN","tr|Q69YM1|Q69YM1_HUMAN;sp|A2RU67|K1467_HUMAN",97,"Q69YM1","Q69YM1_HUMAN",null,null,"FAM234B"]
["21.5067","21.508","22.0579","21.8471",{"$nulls":3},"cell cycle;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination",null,"nuclear body;nucleus",{"$nulls":3},4,4,4,"24.2","24.2","24.2","18.925",0,"77.864",272980000,21,"1.28579","0.326947","-0.445118","-4.22183","sp|Q8WW12|PCNP_HUMAN","sp|Q8WW12|PCNP_HUMAN",2148,"Q8WW12","PCNP_HUMAN","PEST proteolytic signal-containing nuclear protein","CNP;EST-containing nuclear protein","PCNP"]
["22.0888","21.2715","22.2413","22.0098",{"$nulls":9},4,4,4,"17.2","17.2","17.2","34.684",0,"18.792",463900000,31,"0.39321","0.627037","-0.44538","-1.04864","tr|H3BLU7|H3BLU7_HUMAN;sp|O43488|ARK72_HUMAN;sp|Q8NHP1|ARK74_HUMAN;tr|H7C5H7|H7C5H7_HUMAN","tr|H3BLU7|H3BLU7_HUMAN;sp|O43488|ARK72_HUMAN;sp|Q8NHP1|ARK74_HUMAN",248,"H3BLU7","H3BLU7_HUMAN",null,null,"AKR7A2"]
["24.7698","24.6719","25.4492","24.8843",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;nucleolus;nucleoplasm;nucleus;ribosome;small ribosomal subunit","Ribosome",null,null,4,4,4,28,28,28,"13.742",0,"11.539",1632400000,24,"0.584831","0.451394","-0.445875","-1.55537","sp|P62851|RS25_HUMAN","sp|P62851|RS25_HUMAN",1321,"P62851","RS25_HUMAN","40S ribosomal protein S25",null,"RPS25"]
["19.5492","20.0307","21.0574","19.4157",{"$nulls":3},"positive regulation of cell-substrate adhesion;positive regulation of GTPase activity;signal transduction",null,"cytosol;extracellular exosome;focal adhesion",{"$nulls":3},6,6,6,31,31,31,"31.54",0,"14.652",132190000,22,"0.184622","0.834416","-0.446561","-0.522047","sp|Q15404|RSU1_HUMAN","sp|Q15404|RSU1_HUMAN",1700,"Q15404","RSU1_HUMAN","Ras suppressor protein 1","SP-1;su-1","RSU1"]
["20.8972","20.7279","21.494","21.0243",{"$nulls":3},"exocytosis","dipeptidase activity","cytoplasm;nuclear membrane;nucleus",{"$nulls":3},7,7,7,"17.1","17.1","17.1","46.382",0,"37.999",412250000,35,"0.666544","0.388382","-0.446629","-1.78904","sp|Q12765|SCRN1_HUMAN;tr|C9K052|C9K052_HUMAN;tr|B8ZZP4|B8ZZP4_HUMAN;tr|C9J7U9|C9J7U9_HUMAN","sp|Q12765|SCRN1_HUMAN",1490,"Q12765","SCRN1_HUMAN","Secernin-1",null,"SCRN1"]
["17.1889","17.1489","17.6874","17.5437",{"$nulls":4},"aminopeptidase activity;identical protein binding;serine-type peptidase activity","cytosol;nucleus",{"$nulls":3},2,2,2,"2.5","2.5","2.5","98.262",0,"6.1331",80378000,6,"1.57276","0.328154","-0.446656","-5.9914","sp|Q86TI2|DPP9_HUMAN;tr|M0R2A8|M0R2A8_HUMAN","sp|Q86TI2|DPP9_HUMAN;tr|M0R2A8|M0R2A8_HUMAN",1972,"Q86TI2","DPP9_HUMAN","Dipeptidyl peptidase 9","P9","DPP9"]
["16.182","15.8701","17.095","15.8512",{"$nulls":4},"flavin adenine dinucleotide binding;metal ion binding;RNA binding;tRNA dihydrouridine synthase activity",{"$nulls":4},3,3,3,"7.5","7.5","7.5","72.593",0,"6.8854",29542000,9,"0.25351","0.769731","-0.447011","-0.69721","sp|Q96G46|DUS3L_HUMAN;tr|K7EM42|K7EM42_HUMAN;tr|K7EJX8|K7EJX8_HUMAN","sp|Q96G46|DUS3L_HUMAN",2274,"Q96G46","DUS3L_HUMAN","tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like",null,"DUS3L"]
["25.7739","25.827","26.4294","26.0657",{"$nulls":3},"carbohydrate metabolic process;lactate metabolic process;NAD metabolic process;pyruvate metabolic process","identical protein binding;kinase binding;L-lactate dehydrogenase activity;NAD binding","cytoplasm;cytosol;extracellular exosome;membrane;membrane raft;mitochondrion;myelin sheath","Central carbon metabolism in cancer;Cysteine and methionine metabolism;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism",null,null,15,14,14,"50.3","46.7","46.7","36.638",0,"130.44",11232000000,134,"0.868111","0.301994","-0.44703","-2.43254","sp|P07195|LDHB_HUMAN;tr|A8MW50|A8MW50_HUMAN;tr|F5H793|F5H793_HUMAN;tr|C9J7H8|C9J7H8_HUMAN;tr|F5H5G7|F5H5G7_HUMAN;tr|F5H155|F5H155_HUMAN;tr|A0A087WUM2|A0A087WUM2_HUMAN;tr|G3XAP5|G3XAP5_HUMAN;tr|F5H245|F5H245_HUMAN;sp|Q6ZMR3|LDH6A_HUMAN;sp|P07864|LDHC_HUMAN","sp|P07195|LDHB_HUMAN",539,"P07195","LDHB_HUMAN","L-lactate dehydrogenase B chain","DH-B","LDHB"]
["19.7052","19.1399","20.1476","19.5916",{"$nulls":3},"endoplasmic reticulum calcium ion homeostasis","calcium channel activity","endoplasmic reticulum;integral component of endoplasmic reticulum membrane",{"$nulls":3},1,1,1,"13.5","13.5","13.5","11.372","0.0075983","1.7826",45814000,2,"0.424149","0.590718","-0.447045","-1.12761","tr|J3QQY2|J3QQY2_HUMAN;sp|Q9UM00|TMCO1_HUMAN;tr|J9JIE6|J9JIE6_HUMAN","tr|J3QQY2|J3QQY2_HUMAN;sp|Q9UM00|TMCO1_HUMAN;tr|J9JIE6|J9JIE6_HUMAN",2900,"J3QQY2","J3QQY2_HUMAN"]
["24.4716","24.2358","25.0494","24.5527",{"$nulls":3},"chronic inflammatory response to antigenic stimulus;circadian sleep/wake cycle;homocysteine biosynthetic process;methylation;one-carbon metabolic process;response to hypoxia;response to nutrient;S-adenosylhomocysteine catabolic process;S-adenosylmethionine cycle;sulfur amino acid metabolic process","adenosylhomocysteinase activity;adenyl nucleotide binding;identical protein binding;NAD binding","cytosol;extracellular exosome;melanosome;neuron projection;nucleus","Cysteine and methionine metabolism;Metabolic pathways",null,null,13,13,13,"33.1","33.1","33.1","47.716",0,"115.03",5747300000,76,"0.610431","0.428695","-0.447344","-1.62718","sp|P23526|SAHH_HUMAN","sp|P23526|SAHH_HUMAN",782,"P23526","SAHH_HUMAN","Adenosylhomocysteinase","doHcyase","AHCY"]
["20.6903","20.413","21.2274","20.7706",{"$nulls":3},"acetyl-CoA metabolic process;cellular response to interleukin-4;fatty acid biosynthetic process;fatty acid metabolic process;fatty-acyl-CoA biosynthetic process;mammary gland development;osteoblast differentiation;pantothenate metabolic process;positive regulation of cellular metabolic process;regulation of cholesterol biosynthetic process","[acyl-carrier-protein] S-acetyltransferase activity;[acyl-carrier-protein] S-malonyltransferase activity;3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity;3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity;3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity;3-oxoacyl-[acyl-carrier-protein] synthase activity;3-oxo-glutaryl-[acp] methyl ester reductase activity;3-oxo-pimeloyl-[acp] methyl ester reductase activity;cadherin binding;drug binding;enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity;enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity;fatty acid synthase activity;myristoyl-[acyl-carrier-protein] hydrolase activity;NADPH binding;oleoyl-[acyl-carrier-protein] hydrolase activity;palmitoyl-[acyl-carrier-protein] hydrolase activity;phosphopantetheine binding;protein homodimerization activity;RNA binding","cytosol;extracellular exosome;glycogen granule;Golgi apparatus;melanosome;membrane;mitochondrion;plasma membrane","AMPK signaling pathway;Fatty acid biosynthesis;Fatty acid metabolism;Insulin signaling pathway;Metabolic pathways",null,null,47,47,47,"27.5","27.5","27.5","273.42",0,"323.31",3399800000,195,"0.626927","0.417953","-0.447351","-1.67411","sp|P49327|FAS_HUMAN","sp|P49327|FAS_HUMAN",1071,"P49327","FAS_HUMAN","Fatty acid synthase",null,"FASN"]
["21.496","21.6281","22.2503","21.7708",{"$nulls":3},"cellular response to interferon-gamma;CRD-mediated mRNA stabilization;mRNA splicing, via spliceosome;negative regulation of translation;osteoblast differentiation;RNA processing;RNA splicing;viral process","poly(A) binding;RNA binding","catalytic step 2 spliceosome;CRD-mediated mRNA stability complex;endoplasmic reticulum;GAIT complex;histone pre-mRNA 3'end processing complex;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus",{"$nulls":3},9,9,8,"24.9","24.9",23,"69.602",0,"220.76",1141600000,60,"0.671421","0.384189","-0.448505","-1.80342","sp|O60506|HNRPQ_HUMAN;tr|B7Z645|B7Z645_HUMAN;tr|F6UXX1|F6UXX1_HUMAN","sp|O60506|HNRPQ_HUMAN;tr|B7Z645|B7Z645_HUMAN;tr|F6UXX1|F6UXX1_HUMAN",291,"O60506","HNRPQ_HUMAN","Heterogeneous nuclear ribonucleoprotein Q","nRNP Q","SYNCRIP"]
["23.7988","23.8363","24.3193","24.2132",{"$nulls":3},"histone mRNA metabolic process;IRES-dependent viral translational initiation;nuclear histone mRNA catabolic process;protein localization to cytoplasmic stress granule;tRNA 3'-end processing;tRNA 5'-leader removal;tRNA export from nucleus;tRNA modification;tRNA processing","mRNA binding;poly(U) RNA binding;RNA binding;sequence-specific mRNA binding;tRNA binding","cytoplasm;intracellular ribonucleoprotein complex;nuclear chromosome, telomeric region;nucleus","Systemic lupus erythematosus",null,null,14,14,14,"33.1","33.1","33.1","46.836",0,"135.1",3430700000,102,"1.81342","0.373222","-0.448676","-7.9737","sp|P05455|LA_HUMAN;tr|E7ERC4|E7ERC4_HUMAN;tr|E9PGX9|E9PGX9_HUMAN;tr|E9PFL9|E9PFL9_HUMAN","sp|P05455|LA_HUMAN;tr|E7ERC4|E7ERC4_HUMAN",521,"P05455","LA_HUMAN","Lupus La protein",null,"SSB"]
["21.4213","21.5418","22.2667","21.597",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},4,4,4,"31.6","31.6","31.6","15.616",0,"16.071",245980000,19,"0.499386","0.513294","-0.450341","-1.32358","tr|D3YTB1|D3YTB1_HUMAN;sp|P62910|RL32_HUMAN;tr|F8W727|F8W727_HUMAN;tr|D3YTI8|D3YTI8_HUMAN","tr|D3YTB1|D3YTB1_HUMAN;sp|P62910|RL32_HUMAN;tr|F8W727|F8W727_HUMAN",1331,"D3YTB1","D3YTB1_HUMAN",null,null,"RPL32"]
["16.1167","16.1586","17.0715","16.1048",{"$nulls":3},"osteoblast differentiation","NADP-retinol dehydrogenase activity;oxidoreductase activity","endoplasmic reticulum;endoplasmic reticulum membrane;lysosomal membrane;membrane;mitochondrion;nucleus",{"$nulls":3},1,1,1,"5.1","5.1","5.1","36.864",0,"3.9465",16707000,9,"0.346713","0.688018","-0.450494","-0.931147","sp|Q9HBH5|RDH14_HUMAN;tr|C9J2C7|C9J2C7_HUMAN","sp|Q9HBH5|RDH14_HUMAN;tr|C9J2C7|C9J2C7_HUMAN",2635,"Q9HBH5","RDH14_HUMAN","Retinol dehydrogenase 14",null,"RDH14"]
["18.413","17.921","18.7968","18.4385",{"$nulls":4},"ATP binding;RNA binding","fibrillar center;nuclear speck",{"$nulls":3},7,7,7,"9.6","9.6","9.6","117.46",0,"51.695",168180000,27,"0.557907","0.470605","-0.450688","-1.48109","tr|A0A0C4DG89|A0A0C4DG89_HUMAN;sp|Q7L014|DDX46_HUMAN;tr|D6RJA6|D6RJA6_HUMAN","tr|A0A0C4DG89|A0A0C4DG89_HUMAN;sp|Q7L014|DDX46_HUMAN",3067,"A0A0C4DG89","A0A0C4DG89_HUMAN",null,null,"DDX46"]
["22.8934","23.1534","23.508","23.441",{"$nulls":3},"generation of precursor metabolites and energy;mitochondrial electron transport, cytochrome c to oxygen;response to nutrient","cytochrome-c oxidase activity","extracellular exosome;membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex IV;mitochondrion;nucleus","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,7,7,7,"39.1","39.1","39.1","19.576",0,"23.513",1000300000,32,"1.10598","0.309681","-0.451088","-3.3592","sp|P13073|COX41_HUMAN;tr|H3BN72|H3BN72_HUMAN;tr|H3BNV9|H3BNV9_HUMAN;tr|Q86WV2|Q86WV2_HUMAN;tr|H3BPG0|H3BPG0_HUMAN;tr|H3BNI5|H3BNI5_HUMAN","sp|P13073|COX41_HUMAN;tr|H3BN72|H3BN72_HUMAN;tr|H3BNV9|H3BNV9_HUMAN;tr|Q86WV2|Q86WV2_HUMAN;tr|H3BPG0|H3BPG0_HUMAN",653,"P13073","COX41_HUMAN","Cytochrome c oxidase subunit 4 isoform 1, mitochondrial",null,"COX4I1"]
["27.2747","26.8625","27.4101","27.6308",{"$nulls":3},"entry into host cell;establishment of integrated proviral latency;fusion of virus membrane with host plasma membrane;interleukin-12-mediated signaling pathway;leukocyte migration;lipid particle organization;neutrophil degranulation;positive regulation of protein secretion;positive regulation of viral genome replication;protein folding;protein peptidyl-prolyl isomerization;regulation of viral genome replication;RNA-dependent DNA biosynthetic process;uncoating of virus;viral life cycle;viral release from host cell;virion assembly","cyclosporin A binding;peptidyl-prolyl cis-trans isomerase activity;RNA binding;unfolded protein binding;virion binding","cytosol;extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;focal adhesion;membrane;nucleus;secretory granule lumen;vesicle","Necroptosis",null,null,10,10,10,"64.8","64.8","64.8","18.012",0,"169.78",14155000000,97,"0.714458","0.360817","-0.451781","-1.9326","sp|P62937|PPIA_HUMAN;tr|F8WE65|F8WE65_HUMAN;tr|C9J5S7|C9J5S7_HUMAN;tr|E5RIZ5|E5RIZ5_HUMAN;tr|A0A0H2UH34|A0A0H2UH34_HUMAN;tr|A0A075B767|A0A075B767_HUMAN;sp|Q9Y536|PAL4A_HUMAN;sp|P0DN26|PAL4F_HUMAN;sp|F5H284|PAL4D_HUMAN;sp|A0A0B4J2A2|PAL4C_HUMAN;sp|A0A075B759|PAL4E_HUMAN;sp|P0DN37|PAL4G_HUMAN","sp|P62937|PPIA_HUMAN;tr|F8WE65|F8WE65_HUMAN;tr|C9J5S7|C9J5S7_HUMAN",1334,"P62937","PPIA_HUMAN","Peptidyl-prolyl cis-trans isomerase A","PIase A","PPIA"]
["19.9654","20.0421","20.5591","20.3535",{"$nulls":4},"hydrolase activity",{"$nulls":4},1,1,1,"5.3","5.3","5.3","19.756","0.0047409","1.962",105880000,1,"1.26715","0.328316","-0.452568","-4.12467","tr|B4DQI4|B4DQI4_HUMAN;tr|F8W9U3|F8W9U3_HUMAN;sp|Q96IU4|ABHEB_HUMAN","tr|B4DQI4|B4DQI4_HUMAN;tr|F8W9U3|F8W9U3_HUMAN;sp|Q96IU4|ABHEB_HUMAN",2299,"B4DQI4","B4DQI4_HUMAN",null,null,"ABHD14B"]
[1,"17.2597","18.1653",1,{"$nulls":3},"cellular response to DNA damage stimulus;peptidyl-serine ADP-ribosylation;regulation of protein ADP-ribosylation","histone binding","nucleus",{"$nulls":3},1,1,1,"3.2","3.2","3.2","39.436","0.0075883","1.7654",31002000,0,"0.0119199","0.98226","-0.452795","-0.0383016","sp|Q9NWY4|CD027_HUMAN","sp|Q9NWY4|CD027_HUMAN",2732,"Q9NWY4","HPF1_HUMAN","Histone PARylation factor 1 {ECO:0000303|PubMed:27067600, ECO:0000312|HGNC:HGNC:26051}",null,"HPF1"]
["19.3252","19.3428","19.8543","19.7211",{"$nulls":3},"vesicle-mediated transport",null,"membrane",{"$nulls":3},3,3,3,"16.7","16.7","16.7","24.576",0,"9.3201",78640000,4,"1.67311","0.336949","-0.453678","-6.75391","tr|B1AJQ6|B1AJQ6_HUMAN;sp|Q86Y82|STX12_HUMAN","tr|B1AJQ6|B1AJQ6_HUMAN;sp|Q86Y82|STX12_HUMAN",2000,"B1AJQ6","B1AJQ6_HUMAN",null,null,"STX12"]
["12.4098","14.3832","14.257","13.4436",{"$nulls":3},"embryonic skeletal system development",null,"cytoplasm",{"$nulls":3},3,3,3,"2.6","2.6","2.6","214.11",0,"4.8442",22485000,7,"0.14749","0.877152","-0.453815","-0.425234","sp|Q5T5P2|SKT_HUMAN;tr|Q5T5P0|Q5T5P0_HUMAN;tr|Q5T5P1|Q5T5P1_HUMAN","sp|Q5T5P2|SKT_HUMAN",1833,"Q5T5P2","SKT_HUMAN","Sickle tail protein homolog",null,"KIAA1217"]
["17.5374","17.15","18.2708","17.3259",{"$nulls":3},"transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;signal transducer activity","cytosol;nucleoplasm",{"$nulls":3},4,4,4,"10.1","10.1","10.1","76.138",0,"7.9361",81341000,14,"0.330498","0.70328","-0.454643","-0.890402","tr|G8JLH9|G8JLH9_HUMAN;sp|P40763|STAT3_HUMAN","tr|G8JLH9|G8JLH9_HUMAN;sp|P40763|STAT3_HUMAN",973,"G8JLH9","G8JLH9_HUMAN","Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415}",null,"STAT3"]
["20.3259","19.4616","20.6781","20.0205",{"$nulls":3},"translation","RNA binding;structural constituent of ribosome","large ribosomal subunit;mitochondrion",{"$nulls":3},3,3,3,"17.3","17.3","17.3","26.614",0,"5.0594",125120000,10,"0.310007","0.71596","-0.455558","-0.839001","tr|H0Y8N7|H0Y8N7_HUMAN;sp|Q9BYD6|RM01_HUMAN","tr|H0Y8N7|H0Y8N7_HUMAN;sp|Q9BYD6|RM01_HUMAN",2509,"H0Y8N7","H0Y8N7_HUMAN",null,null,"MRPL1"]
["20.3355","20.4919","21.1126","20.626",{"$nulls":5},"cytoplasm;cytosol;extracellular exosome;plasma membrane",{"$nulls":3},10,10,10,"25.8","25.8","25.8","63.964",0,"96.714",599100000,53,"0.664501","0.389385","-0.455636","-1.78303","sp|Q9BW04|SARG_HUMAN","sp|Q9BW04|SARG_HUMAN",2476,"Q9BW04","SARG_HUMAN","Specifically androgen-regulated gene protein",null,"SARG"]
["20.2988","20.2045","20.9532","20.4617",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding","catalytic step 2 spliceosome;mitochondrion;nuclear speck;nucleoplasm;nucleus;spliceosomal complex","Spliceosome",null,null,2,2,2,"5.7","5.7","5.7","26.624",0,"44.295",111780000,8,"0.677565","0.380649","-0.455776","-1.8216","sp|Q9P013|CWC15_HUMAN","sp|Q9P013|CWC15_HUMAN",2767,"Q9P013","CWC15_HUMAN","Spliceosome-associated protein CWC15 homolog",null,"CWC15"]
["26.179","26.3417","26.7154","26.7171",{"$nulls":4},"electron transfer activity;heme binding;metal ion binding","mitochondrion;respiratory chain",{"$nulls":3},7,7,7,"58.4","58.4","58.4","11.333",0,"90.048",4432300000,43,"1.51715","0.324842","-0.455914","-5.60396","tr|C9JFR7|C9JFR7_HUMAN;sp|P99999|CYC_HUMAN;CON__P62894","tr|C9JFR7|C9JFR7_HUMAN;sp|P99999|CYC_HUMAN",1398,"C9JFR7","C9JFR7_HUMAN",null,null,"CYCS"]
["22.5041","22.2458","23.3009","22.3612",{"$nulls":3},"maturation of LSU-rRNA;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;response to ethanol;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;membrane;nucleus","Ribosome",null,null,4,4,4,"19.4","19.4","19.4","24.831",0,"12.895",740770000,25,"0.34869","0.686927","-0.456134","-0.936121","sp|P62906|RL10A_HUMAN","sp|P62906|RL10A_HUMAN",1330,"P62906","RL10A_HUMAN","60S ribosomal protein L10a",null,"RPL10A"]
["14.2143","14.12","14.7274","14.5216",{"$nulls":3},"apoptotic process;cell cycle;cell division;labyrinthine layer development;negative regulation of apoptotic process;negative regulation of extrinsic apoptotic signaling pathway;positive regulation of cell proliferation;protein phosphorylation;protein ubiquitination;regulation of cell proliferation;regulation of cytokinesis;spongiotrophoblast layer development","cysteine-type endopeptidase inhibitor activity;ubiquitin conjugating enzyme activity;ubiquitin-protein transferase activity","endosome;Flemming body;Golgi apparatus;intracellular membrane-bounded organelle;membrane;microtubule organizing center;midbody;spindle pole;trans-Golgi network","Apoptosis - multiple species;Ubiquitin mediated proteolysis",null,null,4,4,4,"1.8","1.8","1.8","530.25",0,"12.1",54075000,16,"1.2507","0.323532","-0.457337","-4.04053","sp|Q9NR09|BIRC6_HUMAN","sp|Q9NR09|BIRC6_HUMAN",2675,"Q9NR09","BIRC6_HUMAN","Baculoviral IAP repeat-containing protein 6",null,"BIRC6"]
["20.7346","20.3371","21.4338","20.5554",{"$nulls":4},"actin binding;ATP binding;motor activity","myosin complex;nuclear body;plasma membrane",{"$nulls":3},21,21,21,"25.8","25.8","25.8","118.99",0,"109.74",833360000,80,"0.354846","0.68","-0.458738","-0.951619","tr|F5H6E2|F5H6E2_HUMAN;sp|O00159|MYO1C_HUMAN;tr|I3L4D4|I3L4D4_HUMAN;tr|I3L501|I3L501_HUMAN;tr|I3L3Y6|I3L3Y6_HUMAN;tr|I3L204|I3L204_HUMAN;tr|I3L168|I3L168_HUMAN;tr|I3L3F5|I3L3F5_HUMAN","tr|F5H6E2|F5H6E2_HUMAN;sp|O00159|MYO1C_HUMAN",119,"F5H6E2","F5H6E2_HUMAN",null,null,"MYO1C"]
["21.4513","20.8412","21.9095","21.301",{"$nulls":3},"generation of precursor metabolites and energy;mitochondrial electron transport, cytochrome c to oxygen","cytochrome-c oxidase activity","integral component of membrane;mitochondrial inner membrane;mitochondrion","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,2,2,2,"18.7","18.7","18.7","8.7813","0.0047635","2.0075",103250000,10,"0.399825","0.62221","-0.459033","-1.06546","sp|P09669|COX6C_HUMAN","sp|P09669|COX6C_HUMAN",593,"P09669","COX6C_HUMAN","Cytochrome c oxidase subunit 6C",null,"COX6C"]
["18.885","18.8519","19.8918","18.7634",{"$nulls":4},"metal ion binding;metalloaminopeptidase activity","cytosol",{"$nulls":3},6,6,6,"18.7","18.7","18.7","62.138",0,"118.19",191600000,23,"0.299822","0.729106","-0.459156","-0.813467","tr|Q5T6H7|Q5T6H7_HUMAN;sp|Q9NQW7|XPP1_HUMAN;tr|Q5T6H3|Q5T6H3_HUMAN;tr|Q5T6H2|Q5T6H2_HUMAN","tr|Q5T6H7|Q5T6H7_HUMAN;sp|Q9NQW7|XPP1_HUMAN",2673,"Q5T6H7","Q5T6H7_HUMAN",null,null,"XPNPEP1"]
["15.9558","16.2301","16.642","16.4638",{"$nulls":3},"intracellular steroid hormone receptor signaling pathway;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;signal transduction;transcription, DNA-templated;Wnt signaling pathway","armadillo repeat domain binding;beta-catenin binding;chromatin binding;core promoter binding;ligand-dependent nuclear receptor transcription coactivator activity;protein C-terminus binding;sequence-specific DNA binding;transcription coactivator activity;transcription cofactor activity;transcription regulatory region DNA binding","cytosol;intracellular membrane-bounded organelle;nuclear chromatin;nucleus",{"$nulls":3},2,2,2,"3.9","3.9","3.9","77.335",0,"12.749",33736000,11,"0.972269","0.297805","-0.459979","-2.8124","sp|Q9P1Z2|CACO1_HUMAN;tr|F8VQE3|F8VQE3_HUMAN","sp|Q9P1Z2|CACO1_HUMAN;tr|F8VQE3|F8VQE3_HUMAN",2779,"Q9P1Z2","CACO1_HUMAN","Calcium-binding and coiled-coil domain-containing protein 1",null,"CALCOCO1"]
["24.3671","24.2947","24.7916","24.7904",{"$nulls":3},"actin filament organization;antigen processing and presentation of exogenous peptide antigen via MHC class II;cellular copper ion homeostasis;cellular response to virus;dendritic spine organization;Golgi to transport vesicle transport;interleukin-12-mediated signaling pathway;long term synaptic depression;lysosomal membrane organization;mitotic cleavage furrow ingression;phosphatidylinositol biosynthetic process;positive regulation of calcium ion-dependent exocytosis;positive regulation of dendritic spine development;positive regulation of endocytosis;positive regulation of ER to Golgi vesicle-mediated transport;positive regulation of late endosome to lysosome transport;positive regulation of protein secretion;positive regulation of sodium ion transmembrane transport;post-Golgi vesicle-mediated transport;protein transport;regulation of Arp2/3 complex-mediated actin nucleation;regulation of defense response to virus by virus;regulation of phospholipid metabolic process;regulation of receptor internalization;small GTPase mediated signal transduction;synaptic vesicle budding;very-low-density lipoprotein particle assembly","GDP binding;GTP binding;GTPase activity;magnesium ion binding;phospholipase D activator activity;protein domain specific binding;protein heterodimerization activity;RNA binding;signal transducer activity, downstream of receptor","cell leading edge;COPI-coated vesicle;cytosol;extracellular exosome;focal adhesion;Golgi membrane;late endosome;neuron projection;perinuclear region of cytoplasm;peroxisomal membrane;plasma membrane;postsynaptic density;postsynaptic membrane;protein complex;sarcomere;trans-Golgi network","Endocytosis;Legionellosis;Phospholipase D signaling pathway;Vibrio cholerae infection",null,null,6,6,5,47,47,"35.4","20.697",0,"106.14",2462600000,58,"2.21236","0.436174","-0.46015","-12.7109","sp|P84077|ARF1_HUMAN;sp|P61204|ARF3_HUMAN;tr|F5H423|F5H423_HUMAN;tr|H0YGG7|H0YGG7_HUMAN;tr|F5H0C7|F5H0C7_HUMAN","sp|P84077|ARF1_HUMAN;sp|P61204|ARF3_HUMAN;tr|F5H423|F5H423_HUMAN",1263,"P84077","ARF1_HUMAN","ADP-ribosylation factor 1",null,"ARF1"]
["18.2431","18.4412","19.1471","18.4584",{"$nulls":3},"activation of adenylate cyclase activity;adenylate cyclase-activating adrenergic receptor signaling pathway;adenylate cyclase-activating dopamine receptor signaling pathway;adenylate cyclase-activating G-protein coupled receptor signaling pathway;bone development;cellular response to catecholamine stimulus;cellular response to glucagon stimulus;cellular response to prostaglandin E stimulus;cognition;developmental growth;G-protein coupled receptor signaling pathway;hair follicle placode formation;intracellular transport;platelet aggregation;positive regulation of cAMP biosynthetic process;positive regulation of cAMP-mediated signaling;positive regulation of GTPase activity;regulation of insulin secretion;renal water homeostasis;sensory perception of smell","G-protein beta/gamma-subunit complex binding;GTP binding;GTPase activity;metal ion binding;signal transducer activity","cytoplasm;cytosol;extracellular exosome;heterotrimeric G-protein complex;intrinsic component of membrane;membrane;plasma membrane;trans-Golgi network membrane","Adrenergic signaling in cardiomyocytes;Alcoholism;Aldosterone synthesis and secretion;Amoebiasis;Amphetamine addiction;Bile secretion;Calcium signaling pathway;cAMP signaling pathway;Chagas disease (American trypanosomiasis);Circadian entrainment;Cocaine addiction;Cortisol synthesis and secretion;Cushing syndrome;Dilated cardiomyopathy (DCM);Dopaminergic synapse;Endocrine and other factor-regulated calcium reabsorption;Endocrine resistance;Estrogen signaling pathway;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Inflammatory mediator regulation of TRP channels;Insulin secretion;Long-term depression;Melanogenesis;Morphine addiction;Ovarian steroidogenesis;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;Phospholipase D signaling pathway;Platelet activation;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Salivary secretion;Serotonergic synapse;Thermogenesis;Thyroid hormone synthesis;Vascular smooth muscle contraction;Vasopressin-regulated water reabsorption;Vibrio cholerae infection",null,null,3,2,2,"10.2","7.4","7.4","45.664",0,"4.6227",91550000,9,"0.484983","0.522468","-0.460608","-1.28556","sp|P63092|GNAS2_HUMAN;sp|Q5JWF2|GNAS1_HUMAN;tr|A0A087WTB6|A0A087WTB6_HUMAN;tr|A2A2R6|A2A2R6_HUMAN;tr|Q5JWD1|Q5JWD1_HUMAN;tr|H0Y7E8|H0Y7E8_HUMAN;tr|A0A087WZE5|A0A087WZE5_HUMAN;tr|A0A0A0MR13|A0A0A0MR13_HUMAN;tr|S4R3E3|S4R3E3_HUMAN;tr|Q5JWE9|Q5JWE9_HUMAN;tr|H0Y7F4|H0Y7F4_HUMAN;sp|P11488|GNAT1_HUMAN;sp|P19087|GNAT2_HUMAN;sp|P09471|GNAO_HUMAN;sp|A8MTJ3|GNAT3_HUMAN;sp|P38405|GNAL_HUMAN","sp|P63092|GNAS2_HUMAN;sp|Q5JWF2|GNAS1_HUMAN",1339,"P63092","GNAS2_HUMAN","Guanine nucleotide-binding protein G(s) subunit alpha isoforms short",null,"GNAS"]
["25.3701","25.4314","25.5859","26.1371",{"$nulls":3},"ion transport","actin filament binding;cadherin binding;ion transmembrane transporter activity;metal ion binding;SH3/SH2 adaptor activity","cortical actin cytoskeleton;cytoplasm;extracellular exosome;focal adhesion",{"$nulls":3},11,11,11,51,51,51,"29.717",0,"269.15",5523300000,122,"0.62244","0.42276","-0.460745","-1.66129","sp|Q14847|LASP1_HUMAN;tr|C9J9W2|C9J9W2_HUMAN;tr|F6S2S5|F6S2S5_HUMAN;tr|K7ESD6|K7ESD6_HUMAN;tr|J3KSN1|J3KSN1_HUMAN","sp|Q14847|LASP1_HUMAN;tr|C9J9W2|C9J9W2_HUMAN",1648,"Q14847","LASP1_HUMAN","LIM and SH3 domain protein 1","ASP-1","LASP1"]
["22.3232","22.1512","22.994","22.4036",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","identical protein binding;polyubiquitin modification-dependent protein binding;RNA binding","cytosol;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, base subcomplex","Epstein-Barr virus infection;Proteasome",null,null,7,7,2,"23.9","23.9","6.9","40.736",0,"142.59",865340000,39,"0.565259","0.46946","-0.461585","-1.50125","sp|P55036|PSMD4_HUMAN;tr|H0Y3Y9|H0Y3Y9_HUMAN","sp|P55036|PSMD4_HUMAN;tr|H0Y3Y9|H0Y3Y9_HUMAN",1203,"P55036","PSMD4_HUMAN","26S proteasome non-ATPase regulatory subunit 4",null,"PSMD4"]
["14.7448","14.484","15.6459","14.5066",{"$nulls":3},"endocytosis;intracellular protein transport",null,"AP-1 adaptor complex;cytoplasm;Golgi apparatus",{"$nulls":3},2,2,2,"2.1","2.1","2.1","140.65","0.0010593","2.3293",23051000,2,"0.290566","0.740308","-0.461826","-0.790263","sp|Q9UMZ2|SYNRG_HUMAN;tr|A0A087WZS7|A0A087WZS7_HUMAN","sp|Q9UMZ2|SYNRG_HUMAN;tr|A0A087WZS7|A0A087WZS7_HUMAN",2904,"Q9UMZ2","SYNRG_HUMAN","Synergin gamma",null,"SYNRG"]
["18.4948","18.4756","19.1367","18.7575",{"$nulls":3},"cell division;centrosome cycle;centrosome duplication;ciliary basal body-plasma membrane docking;establishment or maintenance of microtubule cytoskeleton polarity;G2/M transition of mitotic cell cycle;microtubule depolymerization;microtubule polymerization;regulation of G2/M transition of mitotic cell cycle;RNA transport;sister chromatid cohesion;spindle organization","cadherin binding;microtubule plus-end binding","centrosome;condensed chromosome kinetochore;cytosol;kinetochore;membrane;protein complex;spindle pole",{"$nulls":3},13,13,13,"8.7","8.7","8.7","225.49",0,"85.262",537160000,53,"0.868267","0.302843","-0.461882","-2.43308","sp|Q14008|CKAP5_HUMAN;tr|E9PQH5|E9PQH5_HUMAN;tr|H0YCF6|H0YCF6_HUMAN;tr|H0YEK7|H0YEK7_HUMAN;tr|H0YDX5|H0YDX5_HUMAN","sp|Q14008|CKAP5_HUMAN",1594,"Q14008","CKAP5_HUMAN","Cytoskeleton-associated protein 5",null,"CKAP5"]
["18.6706","18.3103","19.1316","18.7732",{"$nulls":5},"cytosol;intermediate filament cytoskeleton;plasma membrane",{"$nulls":3},8,8,8,10,10,10,"125.47",0,"123.22",333420000,26,"0.676384","0.382589","-0.46192","-1.8181","tr|E9PFQ4|E9PFQ4_HUMAN;sp|Q86SQ0|PHLB2_HUMAN;tr|G5E9V3|G5E9V3_HUMAN;tr|E9PDY7|E9PDY7_HUMAN;tr|E9PGF6|E9PGF6_HUMAN","tr|E9PFQ4|E9PFQ4_HUMAN;sp|Q86SQ0|PHLB2_HUMAN;tr|G5E9V3|G5E9V3_HUMAN;tr|E9PDY7|E9PDY7_HUMAN",1969,"E9PFQ4","E9PFQ4_HUMAN",null,null,"PHLDB2"]
["19.0706","19.1213","19.8116","19.3043",{"$nulls":3},"abscission;cell division;cytokinesis;ESCRT III complex disassembly;establishment of protein localization;multivesicular body assembly;neutrophil degranulation;positive regulation of collateral sprouting;positive regulation of proteolysis;protein localization;protein transport;viral capsid secondary envelopment;viral release from host cell","cadherin binding;identical protein binding;MIT domain binding;protein complex binding;protein domain specific binding","azurophil granule lumen;centrosome;cytosol;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular region;Flemming body;intracellular membrane-bounded organelle;midbody;nuclear envelope","Endocytosis",null,null,1,1,1,"5.2","5.2","5.2","39.75",0,"5.8777",62829000,3,"0.674346","0.382194","-0.461935","-1.81206","sp|P53990|IST1_HUMAN","sp|P53990|IST1_HUMAN",1185,"P53990","IST1_HUMAN","IST1 homolog","IST1","IST1"]
["17.6467","17.4392","17.8151","18.1951",{"$nulls":3},"cellular response to heat","ATP binding;ATPase activity","mitochondrion","Longevity regulating pathway - multiple species",null,null,2,2,2,"3.4","3.4","3.4","78.728",0,"3.7646",78554000,9,"0.779073","0.337324","-0.462131","-2.13497","sp|Q9H078|CLPB_HUMAN;tr|H0YGM0|H0YGM0_HUMAN;tr|F5H392|F5H392_HUMAN;tr|F5H7A5|F5H7A5_HUMAN;tr|F5GX99|F5GX99_HUMAN","sp|Q9H078|CLPB_HUMAN;tr|H0YGM0|H0YGM0_HUMAN;tr|F5H392|F5H392_HUMAN;tr|F5H7A5|F5H7A5_HUMAN;tr|F5GX99|F5GX99_HUMAN",2550,"Q9H078","CLPB_HUMAN","Caseinolytic peptidase B protein homolog",null,"CLPB"]
["22.007","22.4986","22.886","22.544",{"$nulls":3},"cell division;cell proliferation;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;negative regulation of microtubule binding;negative regulation of microtubule polymerization;positive regulation of cell migration;positive regulation of microtubule plus-end binding;protein localization;protein localization to microtubule;regulation of G2/M transition of mitotic cell cycle;sister chromatid cohesion","cadherin binding;identical protein binding;microtubule plus-end binding;protein C-terminus binding;protein kinase binding;RNA binding","cell projection membrane;centrosome;cortical microtubule cytoskeleton;cytoplasmic microtubule;cytosol;Golgi apparatus;microtubule;microtubule plus-end",{"$nulls":3},11,11,11,"61.6","61.6","61.6","29.999",0,"157.2",1008200000,62,"0.580554","0.456878","-0.462178","-1.54349","sp|Q15691|MARE1_HUMAN","sp|Q15691|MARE1_HUMAN",1717,"Q15691","MARE1_HUMAN","Microtubule-associated protein RP/EB family member 1",null,"MAPRE1"]
["14.193","14.2821","15.2969","14.1041",{"$nulls":3},"regulation of small GTPase mediated signal transduction","GTPase activator activity","cytosol;nucleus",{"$nulls":3},1,1,1,"3.4","3.4","3.4","58.591","0.0011291","2.8346",6873700,1,"0.284104","0.745232","-0.462927","-0.774059","tr|H3BQK4|H3BQK4_HUMAN;tr|H3BMQ0|H3BMQ0_HUMAN;sp|P49815|TSC2_HUMAN","tr|H3BQK4|H3BQK4_HUMAN;tr|H3BMQ0|H3BMQ0_HUMAN;sp|P49815|TSC2_HUMAN",1098,"H3BQK4","H3BQK4_HUMAN",null,null,"TSC2"]
["22.5215","22.2809","22.9807","22.7487",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},4,4,4,"50.6","50.6","50.6","8.85",0,"47.302",337130000,17,"0.962184","0.292856","-0.463477","-2.77397","tr|Q8WVC2|Q8WVC2_HUMAN;sp|P63220|RS21_HUMAN;tr|Q9BYK1|Q9BYK1_HUMAN;tr|Q9BYK2|Q9BYK2_HUMAN","tr|Q8WVC2|Q8WVC2_HUMAN;sp|P63220|RS21_HUMAN;tr|Q9BYK1|Q9BYK1_HUMAN",1346,"Q8WVC2","Q8WVC2_HUMAN","40S ribosomal protein S21 {ECO:0000256|PIRNR:PIRNR002148}",null,"RPS21"]
["19.0957","19.0832","19.8839","19.2222",{"$nulls":3},"base-excision repair;cell differentiation;histone ubiquitination;neutrophil degranulation;positive regulation of protein targeting to mitochondrion;protein monoubiquitination;protein polyubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process","DNA binding;RNA binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;nucleus;secretory granule lumen","Ubiquitin mediated proteolysis",null,null,37,37,37,15,15,15,"481.89",0,"323.31",1322100000,131,"0.528438","0.499022","-0.463662","-1.40114","sp|Q7Z6Z7|HUWE1_HUMAN;tr|H0Y659|H0Y659_HUMAN;tr|A0A087X146|A0A087X146_HUMAN;tr|A0A087X1S3|A0A087X1S3_HUMAN","sp|Q7Z6Z7|HUWE1_HUMAN",1964,"Q7Z6Z7","HUWE1_HUMAN","E3 ubiquitin-protein ligase HUWE1",null,"HUWE1"]
["18.3152","17.8343","18.8728","18.2045",{"$nulls":9},13,13,13,"6.7","6.7","6.7","308.77",0,"68.369",399240000,59,"0.423869","0.590316","-0.463915","-1.12689","tr|E7EPN9|E7EPN9_HUMAN;sp|Q9Y520|PRC2C_HUMAN;tr|H7C5N8|H7C5N8_HUMAN;tr|A0A0A0MS30|A0A0A0MS30_HUMAN","tr|E7EPN9|E7EPN9_HUMAN;sp|Q9Y520|PRC2C_HUMAN",3010,"E7EPN9","E7EPN9_HUMAN",null,null,"PRRC2C"]
["20.2439","20.3132","20.8656","20.6204",{"$nulls":5},"nucleus",{"$nulls":3},1,1,1,"4.9","4.9","4.9","25.697",0,"19.431",188900000,12,"1.16957","0.315878","-0.464473","-3.64607","sp|Q9P016|THYN1_HUMAN","sp|Q9P016|THYN1_HUMAN",2768,"Q9P016","THYN1_HUMAN","Thymocyte nuclear protein 1",null,"THYN1"]
["18.9413","17.7886","19.0335","18.6265",{"$nulls":3},"nuclear export;protein transport;snRNA export from nucleus;snRNA transcription from RNA polymerase II promoter","RNA binding;toxic substance binding","Cajal body;centrosome;cytosol;neuronal cell body;nucleoplasm;nucleus","RNA transport",null,null,4,4,4,"10.7","10.7","10.7","44.402",0,"5.0958",101610000,7,"0.278804","0.751474","-0.464997","-0.760766","sp|Q9H814|PHAX_HUMAN","sp|Q9H814|PHAX_HUMAN",2613,"Q9H814","PHAX_HUMAN","Phosphorylated adapter RNA export protein",null,"PHAX"]
["20.1639","20.4524","21.1389","20.4092",{"$nulls":3},"ethanol oxidation;formaldehyde catabolic process;peptidyl-cysteine S-nitrosylation;positive regulation of blood pressure;respiratory system process;response to lipopolysaccharide;response to nitrosative stress;response to redox state;retinoid metabolic process","alcohol dehydrogenase (NAD) activity;electron transfer activity;fatty acid binding;formaldehyde dehydrogenase activity;protein homodimerization activity;S-(hydroxymethyl)glutathione dehydrogenase activity;zinc ion binding","cytosol;extracellular exosome;mitochondrion","Carbon metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Fatty acid degradation;Glycolysis / Gluconeogenesis;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Retinol metabolism;Tyrosine metabolism",null,null,4,4,4,"12.8","12.8","12.8","39.724",0,"6.8829",328840000,14,"0.44745","0.554095","-0.465934","-1.18764","sp|P11766|ADHX_HUMAN;tr|H0YAG8|H0YAG8_HUMAN;tr|D6RAY0|D6RAY0_HUMAN;tr|D6R9G2|D6R9G2_HUMAN;tr|D6RFE4|D6RFE4_HUMAN","sp|P11766|ADHX_HUMAN;tr|H0YAG8|H0YAG8_HUMAN",636,"P11766","ADHX_HUMAN","Alcohol dehydrogenase class-3",null,"ADH5"]
["18.0872","18.025","19.6555","17.3904",{"$nulls":3},"actin filament organization;erythrocyte development;muscle contraction;myofibril assembly;pointed-end actin filament capping;positive regulation of mitotic cell cycle phase transition","actin binding;cadherin binding involved in cell-cell adhesion;tropomyosin binding","cell-cell adherens junction;striated muscle thin filament",{"$nulls":3},3,3,3,"13.6","13.6","13.6","39.594",0,"10.435",65763000,13,"0.142499","0.882861","-0.46682","-0.412033","sp|Q9NYL9|TMOD3_HUMAN;tr|H0YNU8|H0YNU8_HUMAN;tr|H0YKU1|H0YKU1_HUMAN;tr|H0YNJ8|H0YNJ8_HUMAN","sp|Q9NYL9|TMOD3_HUMAN",2751,"Q9NYL9","TMOD3_HUMAN","Tropomodulin-3",null,"TMOD3"]
["17.7986","17.4957","18.7667","17.4619",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,3,3,3,"52.72",0,"8.7644",35643000,6,"0.253611","0.770105","-0.467118","-0.697465","tr|H7C0G1|H7C0G1_HUMAN;sp|Q9H330|TM245_HUMAN","tr|H7C0G1|H7C0G1_HUMAN;sp|Q9H330|TM245_HUMAN",2585,"H7C0G1","H7C0G1_HUMAN",null,null,"TMEM245"]
["20.0055","19.9683","20.8269","20.0812",{"$nulls":3},"glutathione biosynthetic process","alanylglutamate dipeptidase activity;carboxypeptidase activity;cytosolic dipeptidase activity;metal ion binding;metallopeptidase activity","cytosol;extracellular exosome;nucleoplasm","Arginine and proline metabolism;beta-Alanine metabolism;Histidine metabolism;Metabolic pathways",null,null,6,6,6,"17.5","17.5","17.5","52.878",0,"13.278",328700000,25,"0.471948","0.531799","-0.467123","-1.25137","sp|Q96KP4|CNDP2_HUMAN;tr|J3QKT2|J3QKT2_HUMAN;tr|J3KSV5|J3KSV5_HUMAN;tr|A0A087WYZ1|A0A087WYZ1_HUMAN;tr|J3QRH4|J3QRH4_HUMAN;tr|J3KSS4|J3KSS4_HUMAN;tr|J3QQN6|J3QQN6_HUMAN;tr|J3QR27|J3QR27_HUMAN;tr|J3QLU1|J3QLU1_HUMAN;tr|A0A087WVS2|A0A087WVS2_HUMAN;tr|J3QKQ0|J3QKQ0_HUMAN;tr|J3QRD0|J3QRD0_HUMAN;tr|J3QRA8|J3QRA8_HUMAN;tr|J3QL02|J3QL02_HUMAN","sp|Q96KP4|CNDP2_HUMAN;tr|J3QKT2|J3QKT2_HUMAN",2321,"Q96KP4","CNDP2_HUMAN","Cytosolic non-specific dipeptidase",null,"CNDP2"]
["23.1938","23.1013","23.7788","23.4509",{"$nulls":3},"cotranslational protein targeting to membrane;neutrophil degranulation;protein targeting to ER;response to drug;SRP-dependent cotranslational protein targeting to membrane","7S RNA binding;endoplasmic reticulum signal peptide binding;RNA binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleus;secretory granule lumen;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,4,4,4,"27.2","27.2","27.2","14.57",0,"122.18",664190000,33,"0.953973","0.298227","-0.467249","-2.74296","sp|P37108|SRP14_HUMAN;tr|H0YLA2|H0YLA2_HUMAN","sp|P37108|SRP14_HUMAN;tr|H0YLA2|H0YLA2_HUMAN",952,"P37108","SRP14_HUMAN","Signal recognition particle 14 kDa protein","RP14","SRP14"]
["17.1753","15.5476","17.7091","15.9504",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding",{"$nulls":4},1,1,1,"1.7","1.7","1.7","86.604",0,"15.881",28917000,4,"0.134509","0.894091","-0.468234","-0.390787","tr|B7Z6D5|B7Z6D5_HUMAN;sp|Q96GQ7|DDX27_HUMAN","tr|B7Z6D5|B7Z6D5_HUMAN;sp|Q96GQ7|DDX27_HUMAN",2282,"B7Z6D5","B7Z6D5_HUMAN",null,null,"DDX27"]
["19.1163","18.7188","19.6946","19.077",{"$nulls":3},"fatty-acyl-CoA biosynthetic process;gluconeogenesis;mitochondrial citrate transport;mitochondrial transport","citrate transmembrane transporter activity;tricarboxylic acid transmembrane transporter activity","extracellular exosome;integral component of membrane;mitochondrial inner membrane;nucleus",{"$nulls":3},3,3,3,10,10,10,"34.012",0,"16.868",114530000,13,"0.481046","0.524291","-0.468265","-1.27521","sp|P53007|TXTP_HUMAN;tr|B4DP62|B4DP62_HUMAN","sp|P53007|TXTP_HUMAN",1174,"P53007","TXTP_HUMAN","Tricarboxylate transport protein, mitochondrial",null,"SLC25A1"]
["17.1658","16.9351","17.7787","17.259",{"$nulls":3},"cell redox homeostasis;hemopoiesis;protein lipoylation;small molecule metabolic process","2 iron, 2 sulfur cluster binding;electron transfer activity;metal ion binding;protein disulfide oxidoreductase activity","dendrite;mitochondrial matrix;mitochondrion;neuronal cell body;nucleus",{"$nulls":3},1,1,1,"8.9","8.9","8.9","16.628","0.0010764","2.4175",10963000,6,"0.617683","0.424434","-0.468432","-1.64775","sp|Q86SX6|GLRX5_HUMAN","sp|Q86SX6|GLRX5_HUMAN",1970,"Q86SX6","GLRX5_HUMAN","Glutaredoxin-related protein 5, mitochondrial",null,"GLRX5"]
["19.3608","19.3517","19.996","19.6541",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"1.9","1.9","1.9","67.887","0.0020906","2.2194",133420000,13,"0.953379","0.297248","-0.468786","-2.74073","sp|Q9HD45|TM9S3_HUMAN","sp|Q9HD45|TM9S3_HUMAN",2651,"Q9HD45","TM9S3_HUMAN","Transmembrane 9 superfamily member 3",null,"TM9SF3"]
["22.3255","21.9972","23.158","22.1027",{"$nulls":3},"microtubule-based process","GTP binding;GTPase activity;structural constituent of cytoskeleton","cytoplasm;extracellular exosome;microtubule;microtubule cytoskeleton;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,20,11,9,63,"41.5","36.8","49.857",0,"92.661",1535000000,65,"0.313882","0.714542","-0.468985","-0.848716","sp|Q9BUF5|TBB6_HUMAN;tr|K7ESM5|K7ESM5_HUMAN;tr|K7EL29|K7EL29_HUMAN;tr|K7EN98|K7EN98_HUMAN;tr|K7ESQ3|K7ESQ3_HUMAN;tr|K7EQT3|K7EQT3_HUMAN;tr|K7EJ64|K7EJ64_HUMAN;tr|K7ERA8|K7ERA8_HUMAN;tr|K7EJZ4|K7EJZ4_HUMAN;tr|K7ES63|K7ES63_HUMAN;tr|K7EPE5|K7EPE5_HUMAN","sp|Q9BUF5|TBB6_HUMAN;tr|K7ESM5|K7ESM5_HUMAN",2453,"Q9BUF5","TBB6_HUMAN","Tubulin beta-6 chain",null,"TUBB6"]
["21.712","21.4234","22.2111","21.8631",{"$nulls":3},"cell-cell signaling;circadian regulation of gene expression;circadian rhythm;female pregnancy;NAD biosynthesis via nicotinamide riboside salvage pathway;positive regulation of cell proliferation;positive regulation of nitric-oxide synthase biosynthetic process;positive regulation of smooth muscle cell proliferation;positive regulation of transcription from RNA polymerase II promoter;response to organic cyclic compound;signal transduction","cytokine activity;drug binding;identical protein binding;nicotinamide phosphoribosyltransferase activity;nicotinate-nucleotide diphosphorylase (carboxylating) activity;protein homodimerization activity","cell junction;cytosol;extracellular exosome;nuclear speck","Metabolic pathways;Nicotinate and nicotinamide metabolism;NOD-like receptor signaling pathway",null,null,10,10,10,"30.8","30.8","30.8","55.52",0,"176.46",1038800000,54,"0.760735","0.33832","-0.469426","-2.07645","sp|P43490|NAMPT_HUMAN;tr|A0A0C4DFS8|A0A0C4DFS8_HUMAN;tr|C9JF35|C9JF35_HUMAN;tr|C9JG65|C9JG65_HUMAN","sp|P43490|NAMPT_HUMAN;tr|A0A0C4DFS8|A0A0C4DFS8_HUMAN",1013,"P43490","NAMPT_HUMAN","Nicotinamide phosphoribosyltransferase","AmPRTase;ampt","NAMPT"]
["20.7044","20.8385","21.2873","21.1948",{"$nulls":4},"translation elongation factor activity","eukaryotic translation elongation factor 1 complex",{"$nulls":3},6,1,1,"43.3","11.2","11.2","20.819",0,"53.976",195270000,9,"1.54077","0.317261","-0.469629","-5.76563","tr|E9PL71|E9PL71_HUMAN;tr|E9PN91|E9PN91_HUMAN","tr|E9PL71|E9PL71_HUMAN;tr|E9PN91|E9PN91_HUMAN",3092,"E9PL71","E9PL71_HUMAN",null,null,"EEF1D"]
["18.0431","17.8783","18.8101","18.0514",{"$nulls":3},"brain development;cellular response to interferon-gamma;glucose transport;insulin secretion;negative regulation of calcium ion-dependent exocytosis;neutrophil degranulation;platelet aggregation;protein heterooligomerization;protein to membrane docking;response to insulin;vesicle docking involved in exocytosis","syntaxin binding;syntaxin-1 binding","apical plasma membrane;basolateral plasma membrane;cytosol;extracellular exosome;phagocytic vesicle;plasma membrane;platelet alpha granule;specific granule;tertiary granule",{"$nulls":3},4,4,4,"8.8","8.8","8.8","67.764",0,"6.8348",79595000,17,"0.456456","0.544959","-0.47008","-1.21099","sp|O00186|STXB3_HUMAN","sp|O00186|STXB3_HUMAN",124,"O00186","STXB3_HUMAN","Syntaxin-binding protein 3",null,"STXBP3"]
["21.7114","21.4717","22.5138","21.61",{"$nulls":3},"activation of JUN kinase activity;adaptive immune response;neuron projection morphogenesis;neutrophil degranulation;podosome assembly;Rac protein signal transduction;receptor-mediated endocytosis;ruffle assembly;synapse assembly","actin binding;actin filament binding;cadherin binding;enzyme activator activity;protein C-terminus binding;protein domain specific binding","cell cortex;cell junction;clathrin-coated vesicle membrane;cytoplasm;cytosol;dendrite;early endosome;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;Golgi membrane;lamellipodium;plasma membrane;podosome;postsynaptic density;ruffle;secretory granule lumen;tertiary granule lumen",{"$nulls":3},9,9,9,"29.8","29.8","29.8","48.207",0,"228.2",778370000,54,"0.376449","0.647143","-0.470369","-1.00614","sp|Q9UJU6|DBNL_HUMAN;tr|B4DDD6|B4DDD6_HUMAN;tr|H0Y5J4|H0Y5J4_HUMAN;tr|F8WBG8|F8WBG8_HUMAN;tr|F8WC20|F8WC20_HUMAN;tr|F8WBB2|F8WBB2_HUMAN;tr|F8WFE1|F8WFE1_HUMAN;tr|F2Z2V3|F2Z2V3_HUMAN;tr|F8WB73|F8WB73_HUMAN;tr|F8WCK3|F8WCK3_HUMAN;tr|F2Z3E3|F2Z3E3_HUMAN","sp|Q9UJU6|DBNL_HUMAN;tr|B4DDD6|B4DDD6_HUMAN;tr|H0Y5J4|H0Y5J4_HUMAN",2859,"Q9UJU6","DBNL_HUMAN","Drebrin-like protein",null,"DBNL"]
["19.3386",1,"20.2815",1,{"$nulls":9},1,1,1,"7.1","7.1","7.1","11.269","0.0094709","1.6992",20463000,1,"0.0110169","0.982826","-0.471457","-0.0354349","tr|C9JP03|C9JP03_HUMAN;tr|Q5T6P2|Q5T6P2_HUMAN;tr|C9JD09|C9JD09_HUMAN;tr|C9JUW9|C9JUW9_HUMAN;tr|X6RDJ2|X6RDJ2_HUMAN;tr|Q5T6P1|Q5T6P1_HUMAN;tr|X6RGK9|X6RGK9_HUMAN;tr|A0A0C4DFN6|A0A0C4DFN6_HUMAN;sp|Q8ND83|SLAI1_HUMAN;tr|A0A0A0MSS3|A0A0A0MSS3_HUMAN","tr|C9JP03|C9JP03_HUMAN;tr|Q5T6P2|Q5T6P2_HUMAN;tr|C9JD09|C9JD09_HUMAN;tr|C9JUW9|C9JUW9_HUMAN;tr|X6RDJ2|X6RDJ2_HUMAN;tr|Q5T6P1|Q5T6P1_HUMAN;tr|X6RGK9|X6RGK9_HUMAN;tr|A0A0C4DFN6|A0A0C4DFN6_HUMAN;sp|Q8ND83|SLAI1_HUMAN;tr|A0A0A0MSS3|A0A0A0MSS3_HUMAN",2088,"C9JP03","C9JP03_HUMAN",null,null,"SLAIN1"]
["18.8095","18.229","19.0327","18.9492",{"$nulls":3},"metabolic process","acetylpyruvate hydrolase activity;acylpyruvate hydrolase activity;fumarylpyruvate hydrolase activity;metal ion binding;oxaloacetate decarboxylase activity","cytosol;mitochondrial inner membrane;mitochondrion;nucleoplasm","Metabolic pathways;Tyrosine metabolism",null,null,2,2,2,"15.6","15.6","15.6","24.843",0,"9.4903",50136000,14,"0.603928","0.430662","-0.471726","-1.60882","sp|Q6P587|FAHD1_HUMAN","sp|Q6P587|FAHD1_HUMAN",1888,"Q6P587","FAHD1_HUMAN","Acylpyruvase FAHD1, mitochondrial",null,"FAHD1"]
["23.4472","23.1997","23.8526","23.7383",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;neutrophil degranulation;pore complex assembly;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;toxin transport","ATP binding;ATPase activity, coupled;cadherin binding;protein binding involved in protein folding;unfolded protein binding","azurophil granule lumen;cell body;centrosome;chaperonin-containing T-complex;cilium;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intermediate filament cytoskeleton;microtubule;nucleoplasm;secretory granule lumen;zona pellucida receptor complex",{"$nulls":3},26,26,26,"53.8","53.8","53.8","59.62",0,"115.66",4777900000,128,"1.12939","0.310772","-0.472011","-3.46267","sp|P50990|TCPQ_HUMAN;tr|H7C4C8|H7C4C8_HUMAN;tr|H7C2U0|H7C2U0_HUMAN","sp|P50990|TCPQ_HUMAN",1124,"P50990","TCPQ_HUMAN","T-complex protein 1 subunit theta","CP-1-theta","CCT8"]
["15.9051",1,"16.8494",1,{"$nulls":3},"actin cytoskeleton organization;actin nucleation;cleavage furrow formation;establishment of meiotic spindle localization;formin-nucleated actin cable assembly;intracellular transport;polar body extrusion after meiotic divisions;protein transport;vesicle-mediated transport","actin binding","cell cortex;cytoplasmic vesicle membrane;cytoskeleton;cytosol;nucleoplasm;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},1,1,1,3,3,3,"85.543",0,"4.7146",8438400,1,"0.0135308","0.980111","-0.47215","-0.0434022","sp|Q08AE8|SPIR1_HUMAN","sp|Q08AE8|SPIR1_HUMAN",1479,"Q08AE8","SPIR1_HUMAN","Protein spire homolog 1","pir-1","SPIRE1"]
["17.6632","18.4218","18.1217","18.9084",{"$nulls":3},"chaperone-mediated protein folding;negative regulation of Rho-dependent protein serine/threonine kinase activity;regulation of cellular response to heat;regulation of centrosome duplication","ADP binding;ATP binding;Hsp90 protein binding;zinc ion binding",{"$nulls":4},4,4,4,"14.8","14.8","14.8","37.489",0,"12.946",58370000,9,"0.32029","0.710037","-0.472557","-0.864787","sp|Q9UHD1|CHRD1_HUMAN;tr|E9PHZ2|E9PHZ2_HUMAN;tr|E9PPQ5|E9PPQ5_HUMAN;tr|E9PIZ4|E9PIZ4_HUMAN;tr|E9PSD5|E9PSD5_HUMAN","sp|Q9UHD1|CHRD1_HUMAN;tr|E9PHZ2|E9PHZ2_HUMAN;tr|E9PPQ5|E9PPQ5_HUMAN",2829,"Q9UHD1","CHRD1_HUMAN","Cysteine and histidine-rich domain-containing protein 1",null,"CHORDC1"]
["16.2333","15.9117","16.9671","16.1231",{"$nulls":3},"endocytic recycling;endocytosis;positive regulation of histamine secretion by mast cell;protein transport;vesicle organization","epidermal growth factor receptor binding;insulin receptor binding;leptin receptor binding;phosphatidylinositol binding;transferrin receptor binding","cytoplasm;cytoplasmic dynein complex;early endosome membrane;extrinsic component of membrane;membrane;plasma membrane;protein complex;SNARE complex","Endocytosis",null,null,1,1,1,"3.1","3.1","3.1","51.908","0.0010795","2.4452",20286000,4,"0.392376","0.626663","-0.472624","-1.04652","sp|O95219|SNX4_HUMAN","sp|O95219|SNX4_HUMAN",419,"O95219","SNX4_HUMAN","Sorting nexin-4",null,"SNX4"]
["21.5067","21.4712","22.1752","21.748",{"$nulls":3},"rRNA processing","bent DNA binding;DNA binding;double-stranded DNA binding;peptidyl-prolyl cis-trans isomerase activity;RNA binding","cytoplasm;extracellular exosome;mitochondrial matrix;nucleolus;nucleus;preribosome;spindle",{"$nulls":3},3,3,3,"30.5","30.5","30.5","13.81",0,"20.754",288910000,15,"0.800684","0.329373","-0.472639","-2.2051","sp|Q9Y237|PIN4_HUMAN;tr|H0Y4T6|H0Y4T6_HUMAN;tr|J3KMW3|J3KMW3_HUMAN;tr|H0Y8P6|H0Y8P6_HUMAN;tr|H0Y610|H0Y610_HUMAN","sp|Q9Y237|PIN4_HUMAN;tr|H0Y4T6|H0Y4T6_HUMAN;tr|J3KMW3|J3KMW3_HUMAN;tr|H0Y8P6|H0Y8P6_HUMAN;tr|H0Y610|H0Y610_HUMAN",2937,"Q9Y237","PIN4_HUMAN","Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4",null,"PIN4"]
["14.8945","14.4388","16.057","14.2217",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitin-specific protease activity","cytosol;nucleoplasm",{"$nulls":3},2,2,2,"4.3","4.3","4.3","105.03","0.00039078","3.1699",17798000,3,"0.176069","0.844551","-0.472684","-0.499941","tr|G5E9A6|G5E9A6_HUMAN;sp|P51784|UBP11_HUMAN","tr|G5E9A6|G5E9A6_HUMAN;sp|P51784|UBP11_HUMAN",1146,"G5E9A6","G5E9A6_HUMAN"]
["20.6266","20.7452","21.5334","20.785",{"$nulls":3},"actin cytoskeleton organization;apoptotic process;cell migration;cellular response to organic cyclic compound;dendritic spine development;Fc-epsilon receptor signaling pathway;interleukin-12-mediated signaling pathway;negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis;negative regulation of protein kinase activity;peptidyl-serine phosphorylation;phosphorylation;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of peptidyl-tyrosine phosphorylation;protein autophosphorylation;protein phosphorylation;regulation of defense response to virus by virus;regulation of growth;regulation of MAPK cascade;regulation of mitotic cell cycle;Rho protein signal transduction;signal transduction;signal transduction by protein phosphorylation;stimulatory C-type lectin receptor signaling pathway;stress-activated protein kinase signaling cascade;T cell costimulation;T cell receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway","ATP binding;cadherin binding;identical protein binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;protein tyrosine kinase activator activity;Rac GTPase binding;small GTPase binding","cytoplasm;cytosol;nucleus;perinuclear region of cytoplasm;plasma membrane","Axon guidance;ErbB signaling pathway;Focal adhesion;Human immunodeficiency virus 1 infection;MAPK signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway",null,null,8,8,8,"23.5","23.5","23.5","58.042",0,"75.363",558590000,42,"0.471169","0.533097","-0.473304","-1.24933","sp|Q13177|PAK2_HUMAN;tr|E9PM17|E9PM17_HUMAN;tr|B3KNX7|B3KNX7_HUMAN;sp|Q13153|PAK1_HUMAN;tr|H7C1X3|H7C1X3_HUMAN;tr|H0YCG5|H0YCG5_HUMAN;tr|A0A087X294|A0A087X294_HUMAN;sp|O75914|PAK3_HUMAN;tr|B1AKS5|B1AKS5_HUMAN","sp|Q13177|PAK2_HUMAN",1531,"Q13177","PAK2_HUMAN","Serine/threonine-protein kinase PAK 2",null,"PAK2"]
["16.2752","16.4398","17.3536","16.3081",{"$nulls":3},"microtubule anchoring",null,"centrosome",{"$nulls":3},1,1,1,"5.1","5.1","5.1","38.099",0,"4.0877",15760000,5,"0.332138","0.703886","-0.473389","-0.894519","tr|A0A087WV25|A0A087WV25_HUMAN;sp|O95684|FR1OP_HUMAN","tr|A0A087WV25|A0A087WV25_HUMAN;sp|O95684|FR1OP_HUMAN",445,"A0A087WV25","A0A087WV25_HUMAN",null,null,"FGFR1OP"]
["22.8783","22.6402","23.4175","23.0497",{"$nulls":3},"cellular response to cAMP;cellular response to drug;cellular response to gonadotropin-releasing hormone;establishment of endothelial barrier;interleukin-12-mediated signaling pathway;neutrophil degranulation;Rap protein signal transduction;regulation of cell junction assembly;regulation of establishment of cell polarity;response to carbohydrate","GDP binding;GTP binding;GTPase activity;protein complex binding","azurophil granule membrane;cell-cell junction;cytosol;extracellular exosome;intracellular;lipid droplet;membrane;plasma membrane","cAMP signaling pathway;Chemokine signaling pathway;Cushing syndrome;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;MAPK signaling pathway;Neurotrophin signaling pathway;Pancreatic secretion;Platelet activation;Rap1 signaling pathway;Ras signaling pathway;Renal cell carcinoma",null,null,6,6,1,"31.5","31.5","7.1","20.825",0,"14.439",816030000,36,"0.78842","0.33357","-0.474335","-2.16515","sp|P61224|RAP1B_HUMAN;tr|F5GX62|F5GX62_HUMAN;tr|E7ESV4|E7ESV4_HUMAN;tr|F5H7Y6|F5H7Y6_HUMAN;tr|F5H6R7|F5H6R7_HUMAN;tr|F5H004|F5H004_HUMAN;tr|A0A0J9YXB3|A0A0J9YXB3_HUMAN;sp|A6NIZ1|RP1BL_HUMAN;tr|F5H4H0|F5H4H0_HUMAN;tr|F5GYH7|F5GYH7_HUMAN;tr|F5H077|F5H077_HUMAN;tr|F5GWU8|F5GWU8_HUMAN;tr|F5H491|F5H491_HUMAN;tr|F5H0B7|F5H0B7_HUMAN;tr|F5H500|F5H500_HUMAN;tr|F5H823|F5H823_HUMAN;tr|B7ZB78|B7ZB78_HUMAN;tr|F5GZG1|F5GZG1_HUMAN;tr|F5GYB5|F5GYB5_HUMAN;tr|F8WBC0|F8WBC0_HUMAN","sp|P61224|RAP1B_HUMAN;tr|F5GX62|F5GX62_HUMAN;tr|E7ESV4|E7ESV4_HUMAN;tr|F5H7Y6|F5H7Y6_HUMAN;tr|F5H6R7|F5H6R7_HUMAN;tr|F5H004|F5H004_HUMAN;tr|A0A0J9YXB3|A0A0J9YXB3_HUMAN;sp|A6NIZ1|RP1BL_HUMAN;tr|F5H4H0|F5H4H0_HUMAN;tr|F5GYH7|F5GYH7_HUMAN;tr|F5H077|F5H077_HUMAN;tr|F5GWU8|F5GWU8_HUMAN;tr|F5H491|F5H491_HUMAN;tr|F5H0B7|F5H0B7_HUMAN;tr|F5H500|F5H500_HUMAN;tr|F5H823|F5H823_HUMAN;tr|B7ZB78|B7ZB78_HUMAN;tr|F5GZG1|F5GZG1_HUMAN;tr|F5GYB5|F5GYB5_HUMAN",1265,"P61224","RAP1B_HUMAN","Ras-related protein Rap-1b",null,"RAP1B"]
["23.7877","23.9266","24.5773","24.0862",{"$nulls":3},"protein sumoylation","protein tag","nucleus","Fluid shear stress and atherosclerosis;RNA transport",null,null,1,1,1,"12.6","12.6","12.6","10.685",0,"6.1338",682670000,9,"0.690391","0.373937","-0.474597","-1.85984","sp|Q6EEV6|SUMO4_HUMAN;sp|P61956|SUMO2_HUMAN;sp|P55854|SUMO3_HUMAN;tr|A8MUA9|A8MUA9_HUMAN;tr|A8MU27|A8MU27_HUMAN","sp|Q6EEV6|SUMO4_HUMAN;sp|P61956|SUMO2_HUMAN;sp|P55854|SUMO3_HUMAN;tr|A8MUA9|A8MUA9_HUMAN;tr|A8MU27|A8MU27_HUMAN",1215,"Q6EEV6","SUMO4_HUMAN","Small ubiquitin-related modifier 4","UMO-4","SUMO4"]
["17.5198","18.8803","18.5363","18.8143",{"$nulls":3},"COPII-coated vesicle budding;intracellular protein transport","zinc ion binding","COPII vesicle coat;cytosol;endomembrane system;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane;perinuclear region of cytoplasm","Protein processing in endoplasmic reticulum",null,null,4,4,4,6,6,6,"86.478",0,"23.989",186950000,14,"0.248474","0.778288","-0.47524","-0.684526","sp|Q15437|SC23B_HUMAN;tr|Q5QPE1|Q5QPE1_HUMAN;tr|Q5QPE2|Q5QPE2_HUMAN","sp|Q15437|SC23B_HUMAN;tr|Q5QPE1|Q5QPE1_HUMAN;tr|Q5QPE2|Q5QPE2_HUMAN",1705,"Q15437","SC23B_HUMAN","Protein transport protein Sec23B {ECO:0000305}","Sec23B {ECO:0000303|PubMed:8898360}","SEC23B"]
["19.7553","19.5983","20.3099","19.9947",{"$nulls":3},"cellular response to oxygen-glucose deprivation;cellular response to thapsigargin;dynamin family protein polymerization involved in mitochondrial fission;endocytosis;execution phase of apoptosis;heart contraction;intracellular distribution of mitochondria;membrane fusion;mitochondrial fission;mitochondrial fragmentation involved in apoptotic process;mitochondrial membrane fission;mitochondrion morphogenesis;mitochondrion organization;necroptotic process;negative regulation of mitochondrial fusion;peroxisome fission;positive regulation of apoptotic process;positive regulation of dendritic spine morphogenesis;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial fission;positive regulation of protein secretion;positive regulation of release of cytochrome c from mitochondria;positive regulation of synaptic vesicle endocytosis;positive regulation of synaptic vesicle exocytosis;protein homotetramerization;protein localization to mitochondrion;protein oligomerization;regulation of ATP metabolic process;regulation of autophagy of mitochondrion;regulation of mitochondrion organization;regulation of peroxisome organization;regulation of protein oligomerization;release of cytochrome c from mitochondria;response to flavonoid;response to hypobaric hypoxia;synaptic vesicle recycling via endosome","BH2 domain binding;clathrin binding;GTP binding;GTPase activator activity;GTPase activity;GTP-dependent protein binding;identical protein binding;lipid binding;microtubule binding;protein complex binding;protein homodimerization activity;Rab GTPase binding;ubiquitin protein ligase binding","brush border;cell junction;clathrin-coated pit;cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle;membrane;microtubule;microtubule cytoskeleton;mitochondrial outer membrane;mitochondrion;perinuclear region of cytoplasm;peroxisome;protein complex;synaptic vesicle membrane","Necroptosis;NOD-like receptor signaling pathway;TNF signaling pathway",null,null,14,14,3,"31.2","31.2","8.2","81.876",0,"178.37",504330000,40,"0.942547","0.296361","-0.475428","-2.70021","sp|O00429|DNM1L_HUMAN;tr|B4DPZ9|B4DPZ9_HUMAN;tr|F8W1W3|F8W1W3_HUMAN;tr|F8VZ52|F8VZ52_HUMAN;tr|F8VUJ9|F8VUJ9_HUMAN;tr|B4DDQ3|B4DDQ3_HUMAN","sp|O00429|DNM1L_HUMAN",141,"O00429","DNM1L_HUMAN","Dynamin-1-like protein",null,"DNM1L"]
["20.4671","20.4147","21.0691","20.7652",{"$nulls":5},"nucleus",{"$nulls":3},4,4,4,"16.5","16.5","16.5","30.693","0.0003962","3.3031",178190000,6,"1.04202","0.300023","-0.476258","-3.08864","tr|B0S8I6|B0S8I6_HUMAN;sp|Q14320|FA50A_HUMAN;sp|Q9Y247|FA50B_HUMAN","tr|B0S8I6|B0S8I6_HUMAN;sp|Q14320|FA50A_HUMAN",1619,"B0S8I6","B0S8I6_HUMAN",null,null,"FAM50A"]
["19.5923","19.2536","19.676","20.1226",{"$nulls":4},"arylesterase activity","extracellular region",{"$nulls":3},2,2,2,"10.2","10.2","10.2","37.98",0,"89.117",156400000,21,"0.635778","0.408598","-0.476335","-1.69951","tr|J3QT77|J3QT77_HUMAN;tr|A0A0J9YYG4|A0A0J9YYG4_HUMAN;sp|Q15165|PON2_HUMAN;tr|A0A0J9YXF2|A0A0J9YXF2_HUMAN;tr|A0A0J9YYJ1|A0A0J9YYJ1_HUMAN","tr|J3QT77|J3QT77_HUMAN;tr|A0A0J9YYG4|A0A0J9YYG4_HUMAN;sp|Q15165|PON2_HUMAN;tr|A0A0J9YXF2|A0A0J9YXF2_HUMAN;tr|A0A0J9YYJ1|A0A0J9YYJ1_HUMAN",1681,"J3QT77","J3QT77_HUMAN",null,null,"PON2"]
["20.1667","20.1561","21.1253","20.1508",{"$nulls":3},"actin cytoskeleton organization;actin filament network formation;Arp2/3 complex-mediated actin nucleation;cell migration;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;lamellipodium organization;maintenance of cell polarity;membrane organization;microtubule organizing center localization;movement of cell or subcellular component;neutrophil degranulation;orbitofrontal cortex development;smooth muscle cell migration","actin binding;structural constituent of cytoskeleton","actin cytoskeleton;Arp2/3 protein complex;cytoplasm;cytosol;endosome;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;growth cone;lamellipodium;secretory granule lumen","Bacterial invasion of epithelial cells;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,2,2,2,"15.2","15.2","15.2","16.32",0,"7.9211",130720000,10,"0.365376","0.664094","-0.476637","-0.978168","sp|O15511|ARPC5_HUMAN;tr|B1ALC0|B1ALC0_HUMAN","sp|O15511|ARPC5_HUMAN;tr|B1ALC0|B1ALC0_HUMAN",225,"O15511","ARPC5_HUMAN","Actin-related protein 2/3 complex subunit 5",null,"ARPC5"]
["17.3263","17.2719","18.2393","17.3157",{"$nulls":3},"apoptotic process;endocytosis;membrane fusion;protein transport;vesicle-mediated transport","growth factor activity;GTPase activator activity;protein domain specific binding;protein homodimerization activity","early endosome;early endosome membrane;endocytic vesicle;endosome;intracellular membrane-bounded organelle;protein complex;recycling endosome","Endocytosis",null,null,5,5,5,"7.1","7.1","7.1","99.289",0,"7.1021",107970000,8,"0.387448","0.632974","-0.478351","-1.03401","sp|Q15276|RABE1_HUMAN;tr|I3L2B8|I3L2B8_HUMAN;tr|K7ENJ9|K7ENJ9_HUMAN","sp|Q15276|RABE1_HUMAN",1687,"Q15276","RABE1_HUMAN","Rab GTPase-binding effector protein 1",null,"RABEP1"]
["15.6214",1,"16.5786",1,{"$nulls":3},"acrosome reaction;detection of mechanical stimulus","calcium channel activity;calcium ion binding","integral component of membrane;membrane",{"$nulls":3},1,1,1,"0.3","0.3","0.3","255.45","0.009772","1.6883",32271000,2,"0.0139727","0.98081","-0.478564","-0.0447982","sp|Q9NTG1|PKDRE_HUMAN","sp|Q9NTG1|PKDRE_HUMAN",2696,"Q9NTG1","PKDRE_HUMAN","Polycystic kidney disease and receptor for egg jelly-related protein",null,"PKDREJ"]
["17.0055","17.3119","17.8549","17.4226",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;poly(A)+ mRNA export from nucleus;positive regulation of translation;RNA export from nucleus;termination of RNA polymerase II transcription","RNA binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;nuclear speck;nucleoplasm",{"$nulls":3},2,2,2,"7.4","7.4","7.4","46.089",0,"5.0356",40742000,11,"0.674351","0.382588","-0.480079","-1.81208","sp|Q9BY77|PDIP3_HUMAN;tr|F6VRR5|F6VRR5_HUMAN;tr|Q8WUT1|Q8WUT1_HUMAN;tr|F8WCX5|F8WCX5_HUMAN","sp|Q9BY77|PDIP3_HUMAN;tr|F6VRR5|F6VRR5_HUMAN;tr|Q8WUT1|Q8WUT1_HUMAN;tr|F8WCX5|F8WCX5_HUMAN",2507,"Q9BY77","PDIP3_HUMAN","Polymerase delta-interacting protein 3",null,"POLDIP3"]
["19.3957","19.0375","20.2235","19.1701",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","protein domain specific binding;RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleolus",{"$nulls":3},4,4,4,"14.4","14.4","14.4","45.318",0,"11.104",162640000,17,"0.319675","0.709299","-0.480235","-0.863243","sp|Q92665|RT31_HUMAN","sp|Q92665|RT31_HUMAN",2183,"Q92665","RT31_HUMAN","28S ribosomal protein S31, mitochondrial","31mt;RP-S31","MRPS31"]
["19.2281","19.0815","19.6033","19.6686",{"$nulls":3},"GMP biosynthetic process","IMP dehydrogenase activity;metal ion binding;nucleotide binding","cytosol;nucleus",{"$nulls":3},2,1,1,"3.9","2.3","2.3","55.277",0,"13.305",164550000,8,"1.57349","0.33134","-0.481144","-5.99666","tr|C9J381|C9J381_HUMAN;sp|P20839|IMDH1_HUMAN","tr|C9J381|C9J381_HUMAN;sp|P20839|IMDH1_HUMAN",748,"C9J381","C9J381_HUMAN","Inosine-5'-monophosphate dehydrogenase {ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|RuleBase:RU003928}","MP dehydrogenase {ECO:0000256|HAMAP-Rule:MF_03156};MPD {ECO:0000256|HAMAP-Rule:MF_03156};MPDH {ECO:0000256|HAMAP-Rule:MF_03156}","IMPDH1"]
["22.2418","22.3659","23.0581","22.5128",{"$nulls":3},"eukaryotic translation initiation factor 4F complex assembly;formation of translation preinitiation complex;nuclear-transcribed mRNA poly(A) tail shortening;regulation of translational initiation;translational initiation","helicase activity;ribosomal small subunit binding;RNA binding;RNA strand annealing activity;RNA strand-exchange activity;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 4F complex;polysome","mTOR signaling pathway;PI3K-Akt signaling pathway;Proteoglycans in cancer;RNA transport",null,null,13,13,13,"28.2","28.2","28.2","69.15",0,"187.8",1580500000,88,"0.64362","0.400381","-0.481604","-1.72214","sp|P23588|IF4B_HUMAN;tr|E7EX17|E7EX17_HUMAN;tr|F8VSC7|F8VSC7_HUMAN;tr|F8VP89|F8VP89_HUMAN;tr|F8VX11|F8VX11_HUMAN;tr|F8VYE9|F8VYE9_HUMAN;tr|F8W0K0|F8W0K0_HUMAN;tr|F8VRU1|F8VRU1_HUMAN","sp|P23588|IF4B_HUMAN;tr|E7EX17|E7EX17_HUMAN;tr|F8VSC7|F8VSC7_HUMAN;tr|F8VP89|F8VP89_HUMAN;tr|F8VX11|F8VX11_HUMAN",784,"P23588","IF4B_HUMAN","Eukaryotic translation initiation factor 4B","IF-4B","EIF4B"]
["21.8438","22.3153","22.9666","22.1557",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex;secretory granule lumen","Proteasome",null,null,8,8,8,44,44,44,"26.489",0,"90.619",867660000,36,"0.384662","0.63682","-0.481665","-1.02694","sp|P20618|PSB1_HUMAN","sp|P20618|PSB1_HUMAN",744,"P20618","PSB1_HUMAN","Proteasome subunit beta type-1",null,"PSMB1"]
["20.8667","21.0005","21.701","21.1297",{"$nulls":3},"aging;dATP catabolic process;dGTP catabolic process;DNA protection;DNA repair;male gonad development;nucleobase-containing small molecule catabolic process;purine nucleotide catabolic process;response to cadmium ion;response to oxidative stress","2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity;2-hydroxy-adenosine triphosphate pyrophosphatase activity;8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;ATP diphosphatase activity;GTP diphosphatase activity;GTPase activity;metal ion binding;snoRNA binding","acrosomal vesicle;cytoplasm;cytosol;extracellular exosome;mitochondrial matrix;mitochondrion;nuclear membrane;nucleus;plasma membrane",{"$nulls":3},4,4,4,"20.8","20.8","20.8","22.519",0,"90.13",227370000,24,"0.615739","0.424657","-0.481755","-1.64222","sp|P36639|8ODP_HUMAN","sp|P36639|8ODP_HUMAN",946,"P36639","8ODP_HUMAN","7,8-dihydro-8-oxoguanine triphosphatase",null,"NUDT1"]
["22.2918","21.8823","22.5991","22.5418",{"$nulls":3},"translation","rRNA binding;structural constituent of ribosome","ribosome","Ribosome",null,null,5,5,5,"47.9","47.9","47.9","21.863",0,"71.744",457000000,29,"0.840568","0.311377","-0.483389","-2.338","tr|Q53Z07|Q53Z07_HUMAN;sp|P32969|RL9_HUMAN;tr|D6RAN4|D6RAN4_HUMAN;tr|H0Y9V9|H0Y9V9_HUMAN;tr|E7ESE0|E7ESE0_HUMAN;tr|H0Y9R4|H0Y9R4_HUMAN","tr|Q53Z07|Q53Z07_HUMAN;sp|P32969|RL9_HUMAN;tr|D6RAN4|D6RAN4_HUMAN;tr|H0Y9V9|H0Y9V9_HUMAN;tr|E7ESE0|E7ESE0_HUMAN",907,"Q53Z07","Q53Z07_HUMAN",null,null,"RPL9"]
["18.1145","18.1247","18.7869","18.42",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"26.4","26.4","26.4","14.164","0.00077101","3.0277",17128000,4,"0.925478","0.295938","-0.48387","-2.63719","tr|K7EQB1|K7EQB1_HUMAN;sp|Q9UNK0|STX8_HUMAN","tr|K7EQB1|K7EQB1_HUMAN;sp|Q9UNK0|STX8_HUMAN",2912,"K7EQB1","K7EQB1_HUMAN",null,null,"STX8"]
["16.2588","15.5561","16.8398","15.947",{"$nulls":3},"autophagy;endocytic recycling;Golgi organization;Golgi vesicle transport;lipid transport;lysosomal transport;protein transport;retrograde transport, endosome to Golgi",null,"cytosol;EARP complex;GARP complex;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;membrane;nucleolus;recycling endosome;trans-Golgi network membrane",{"$nulls":3},1,1,1,"1.9","1.9","1.9","86.041","0.001105","2.681",30952000,8,"0.316546","0.713984","-0.485952","-0.855397","sp|Q9UID3|VPS51_HUMAN","sp|Q9UID3|VPS51_HUMAN",2849,"Q9UID3","VPS51_HUMAN","Vacuolar protein sorting-associated protein 51 homolog",null,"VPS51"]
["20.5665","20.1885","21.0535","20.6736",{"$nulls":3},"formation of cytoplasmic translation initiation complex;IRES-dependent viral translational initiation;negative regulation of ERK1 and ERK2 cascade;translation reinitiation;translational initiation;viral translational termination-reinitiation","mRNA binding;receptor tyrosine kinase binding;RNA binding;structural molecule activity;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3e;eukaryotic translation initiation factor 3 complex, eIF3m;membrane;microtubule;multi-eIF complex;nucleolus;nucleus","RNA transport",null,null,24,24,24,"20.5","20.5","20.5","166.57",0,"118.89",1037800000,89,"0.67487","0.382421","-0.486047","-1.81362","sp|Q14152|EIF3A_HUMAN","sp|Q14152|EIF3A_HUMAN",1603,"Q14152","EIF3A_HUMAN","Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000}","IF3a {ECO:0000255|HAMAP-Rule:MF_03000}","EIF3A"]
["17.9055","17.6519","18.4973","18.0338",{"$nulls":3},"axon extension;BMP signaling pathway;cell cycle;cell division;cellular protein metabolic process;chromosome segregation;female gamete generation;negative regulation of transcription from RNA polymerase II promoter;neuron migration;protein deubiquitination;protein ubiquitination;transforming growth factor beta receptor signaling pathway;ubiquitin-dependent protein catabolic process","co-SMAD binding;cysteine-type endopeptidase activity;cysteine-type peptidase activity;thiol-dependent ubiquitinyl hydrolase activity","cytoplasm;cytosol;growth cone;membrane",{"$nulls":3},7,7,7,"4.2","4.2","4.2","292.28",0,"48.055",363690000,32,"0.684691","0.376704","-0.486812","-1.8428","sp|Q93008|USP9X_HUMAN;sp|O00507|USP9Y_HUMAN","sp|Q93008|USP9X_HUMAN",2212,"Q93008","USP9X_HUMAN","Probable ubiquitin carboxyl-terminal hydrolase FAF-X",null,"USP9X"]
["21.5567","21.4378","22.1665","21.8017",{"$nulls":3},"mitochondrial membrane organization;protein dephosphorylation;protein import into mitochondrial matrix;release of cytochrome c from mitochondria","interleukin-2 receptor binding;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity;protein tyrosine phosphatase activity;ribonucleoprotein complex binding;RNA binding","integral component of membrane;mitochondrial inner membrane;mitochondrial inner membrane presequence translocase complex;mitochondrion;nuclear speck;nucleoplasm",{"$nulls":3},4,4,4,"15.9","15.9","15.9","39.646",0,"115.22",449520000,31,"0.897891","0.299268","-0.486848","-2.53743","sp|Q3ZCQ8|TIM50_HUMAN;tr|M0QXC3|M0QXC3_HUMAN;tr|M0R2Z3|M0R2Z3_HUMAN;tr|M0R303|M0R303_HUMAN;tr|M0R2D2|M0R2D2_HUMAN;tr|M0R047|M0R047_HUMAN;tr|M0R1Y4|M0R1Y4_HUMAN;tr|M0R003|M0R003_HUMAN;tr|M0R0C3|M0R0C3_HUMAN;tr|M0R2F8|M0R2F8_HUMAN","sp|Q3ZCQ8|TIM50_HUMAN;tr|M0QXC3|M0QXC3_HUMAN;tr|M0R2Z3|M0R2Z3_HUMAN;tr|M0R303|M0R303_HUMAN;tr|M0R2D2|M0R2D2_HUMAN;tr|M0R047|M0R047_HUMAN;tr|M0R1Y4|M0R1Y4_HUMAN;tr|M0R003|M0R003_HUMAN",1784,"Q3ZCQ8","TIM50_HUMAN","Mitochondrial import inner membrane translocase subunit TIM50",null,"TIMM50"]
["16.9441","17.0867","18.0147","16.9926",{"$nulls":3},"cell cycle arrest;G1/S transition of mitotic cell cycle;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;post-translational protein modification;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;viral process","protein complex binding;ubiquitin protein ligase binding","Cul2-RING ubiquitin ligase complex;cytosol;nucleolus;nucleoplasm;VCB complex","HIF-1 signaling pathway;Pathways in cancer;Renal cell carcinoma;Ubiquitin mediated proteolysis",null,null,3,3,3,"4.2","4.2","4.2","86.982",0,"18.829",71928000,17,"0.352695","0.683239","-0.488251","-0.946201","sp|Q13617|CUL2_HUMAN;tr|A0A0A0MTN0|A0A0A0MTN0_HUMAN;tr|Q5T2B5|Q5T2B5_HUMAN","sp|Q13617|CUL2_HUMAN;tr|A0A0A0MTN0|A0A0A0MTN0_HUMAN;tr|Q5T2B5|Q5T2B5_HUMAN",1578,"Q13617","CUL2_HUMAN","Cullin-2","UL-2","CUL2"]
["22.0899","22.0481","22.9172","22.1978",{"$nulls":3},"cyclooxygenase pathway;drug metabolic process;epithelial cell differentiation;oxidation-reduction process;vitamin K metabolic process","15-hydroxyprostaglandin dehydrogenase (NADP+) activity;carbonyl reductase (NADPH) activity;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;prostaglandin-E2 9-reductase activity","cytosol;extracellular exosome;extracellular vesicle","Arachidonic acid metabolism;Chemical carcinogenesis;Folate biosynthesis;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450",null,null,7,7,5,"42.2","42.2","31.8","30.375",0,"102.36",824460000,47,"0.511541","0.512274","-0.488502","-1.35589","sp|P16152|CBR1_HUMAN;tr|E9PQ63|E9PQ63_HUMAN;tr|A8MTM1|A8MTM1_HUMAN","sp|P16152|CBR1_HUMAN;tr|E9PQ63|E9PQ63_HUMAN;tr|A8MTM1|A8MTM1_HUMAN",694,"P16152","CBR1_HUMAN","Carbonyl reductase [NADPH] 1",null,"CBR1"]
["16.6972","17.577","17.6865","17.5647",{"$nulls":3},"mRNA processing","ubiquitin protein ligase activity;zinc ion binding","nucleus",{"$nulls":3},1,1,1,"8.9","8.9","8.9","17.316","0.0010838","2.491",17797000,2,"0.413399","0.600235","-0.488502","-1.10008","tr|I3L3Y2|I3L3Y2_HUMAN;tr|H3BUN0|H3BUN0_HUMAN;sp|Q7Z6E9|RBBP6_HUMAN","tr|I3L3Y2|I3L3Y2_HUMAN;tr|H3BUN0|H3BUN0_HUMAN;sp|Q7Z6E9|RBBP6_HUMAN",1962,"I3L3Y2","I3L3Y2_HUMAN",null,null,"RBBP6"]
["19.6589","19.5788","20.5123","19.7024",{"$nulls":3},"regulation of transcription, DNA-templated",null,"NELF complex;nuclear body;nucleoplasm;plasma membrane",{"$nulls":3},5,5,5,27,27,27,"33.611",0,"23.365",117270000,20,"0.45244","0.552303","-0.488532","-1.20057","tr|A0A0A0MT02|A0A0A0MT02_HUMAN;tr|A0A0A0MSN9|A0A0A0MSN9_HUMAN;sp|P18615|NELFE_HUMAN;tr|A0A0G2JI50|A0A0G2JI50_HUMAN;tr|E9PD43|E9PD43_HUMAN;tr|A2ABK4|A2ABK4_HUMAN","tr|A0A0A0MT02|A0A0A0MT02_HUMAN;tr|A0A0A0MSN9|A0A0A0MSN9_HUMAN;sp|P18615|NELFE_HUMAN;tr|A0A0G2JI50|A0A0G2JI50_HUMAN;tr|E9PD43|E9PD43_HUMAN;tr|A2ABK4|A2ABK4_HUMAN",721,"A0A0A0MT02","A0A0A0MT02_HUMAN",null,null,"NELFE"]
["21.0437","20.6768","21.6655","21.0328",{"$nulls":3},"methylation;one-carbon metabolic process;S-adenosylmethionine biosynthetic process","enzyme binding;methionine adenosyltransferase regulator activity","cytosol;extracellular exosome;intracellular;methionine adenosyltransferase complex;mitochondrion;nucleus","Biosynthesis of amino acids;Cysteine and methionine metabolism;Metabolic pathways",null,null,6,6,6,"23.7","23.7","23.7","37.551",0,"17.685",429970000,24,"0.504448","0.513428","-0.488893","-1.33701","sp|Q9NZL9|MAT2B_HUMAN;tr|H7C0X7|H7C0X7_HUMAN;tr|E5RJR3|E5RJR3_HUMAN","sp|Q9NZL9|MAT2B_HUMAN;tr|H7C0X7|H7C0X7_HUMAN",2760,"Q9NZL9","MAT2B_HUMAN","Methionine adenosyltransferase 2 subunit beta",null,"MAT2B"]
["18.9323","18.7483","19.5075","19.1509",{"$nulls":4},"RNA binding","cytosol;membrane;nucleus;plasma membrane",{"$nulls":3},5,5,5,"8.9","8.9","8.9","121.89",0,"74.325",320200000,26,"0.869334","0.303696","-0.488903","-2.43679","sp|Q9NZB2|F120A_HUMAN;tr|A0A0C4DH52|A0A0C4DH52_HUMAN;sp|Q5T035|CI129_HUMAN;tr|A0A0C4DG79|A0A0C4DG79_HUMAN","sp|Q9NZB2|F120A_HUMAN",2756,"Q9NZB2","F120A_HUMAN","Constitutive coactivator of PPAR-gamma-like protein 1",null,"FAM120A"]
["17.4495","16.8165","17.9359","17.3093",{"$nulls":3},"vesicle docking involved in exocytosis",null,"exocyst",{"$nulls":3},1,1,1,"9.8","9.8","9.8","17.709",0,"3.5215",10592000,2,"0.413096","0.600921","-0.489587","-1.09931","tr|B1AP46|B1AP46_HUMAN;tr|E7EW84|E7EW84_HUMAN;sp|Q8TAG9|EXOC6_HUMAN","tr|B1AP46|B1AP46_HUMAN;tr|E7EW84|E7EW84_HUMAN;sp|Q8TAG9|EXOC6_HUMAN",2106,"B1AP46","B1AP46_HUMAN",null,null,"EXOC6"]
["19.0018","19.1157","19.624","19.4739",{"$nulls":3},"translation","structural constituent of ribosome","mitochondrial inner membrane;ribosome",{"$nulls":3},1,1,1,"16.1","16.1","16.1","10.688","0.00075614","2.8676",22640000,9,"1.4559","0.32096","-0.490228","-5.20367","tr|A0A075B746|A0A075B746_HUMAN;sp|P82921|RT21_HUMAN","tr|A0A075B746|A0A075B746_HUMAN;sp|P82921|RT21_HUMAN",1384,"A0A075B746","A0A075B746_HUMAN",null,null,"MRPS21"]
["16.0931","15.8687","16.982","15.9602",{"$nulls":3},"cell cycle arrest;cell proliferation;cellular response to DNA damage stimulus;ERBB2 signaling pathway;G1/S transition of mitotic cell cycle;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;post-translational protein modification;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;viral process","calcium channel activity;receptor activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","Cul4-RING E3 ubiquitin ligase complex;Cul5-RING ubiquitin ligase complex;cytosol","Human immunodeficiency virus 1 infection;Ubiquitin mediated proteolysis",null,null,2,2,2,"3.6","3.6","3.6","90.954",0,"7.1287",36982000,6,"0.349131","0.687193","-0.490251","-0.937231","sp|Q93034|CUL5_HUMAN","sp|Q93034|CUL5_HUMAN",2214,"Q93034","CUL5_HUMAN","Cullin-5","UL-5","CUL5"]
["16.3137","16.064","16.8654","16.4928",{"$nulls":3},"actin cytoskeleton reorganization;activation of JNKK activity;cytoskeleton organization;intracellular signal transduction;microvillus assembly;positive regulation of protein phosphorylation;protein autophosphorylation;protein localization to plasma membrane;protein phosphorylation;regulation of apoptotic process;regulation of dendrite morphogenesis;regulation of mitotic cell cycle;Wnt signaling pathway","ATP binding;MAP kinase kinase kinase kinase activity;protein kinase activity;protein serine/threonine kinase activity","apical plasma membrane;cytoplasm;cytoskeleton;cytosol;extracellular exosome;nucleoplasm;nucleus;recycling endosome",{"$nulls":3},3,2,2,"3.4","2.4","2.4","154.94",0,"3.566",48149000,2,"0.79483","0.331581","-0.490295","-2.18598","sp|Q9UKE5|TNIK_HUMAN","sp|Q9UKE5|TNIK_HUMAN",2867,"Q9UKE5","TNIK_HUMAN","TRAF2 and NCK-interacting protein kinase",null,"TNIK"]
["15.727","15.6849","16.3939","15.9987",{"$nulls":3},"cytoplasmic microtubule organization;microtubule nucleation;positive regulation of microtubule polymerization",null,"centrosome;cytosol;microtubule cytoskeleton",{"$nulls":3},1,1,1,"2.9","2.9","2.9","62.543","0.00076132","2.9125",18808000,6,"0.878263","0.302375","-0.49036","-2.46798","sp|Q9P270|SLAI2_HUMAN","sp|Q9P270|SLAI2_HUMAN",2783,"Q9P270","SLAI2_HUMAN","SLAIN motif-containing protein 2",null,"SLAIN2"]
["17.5126","16.6676","18.0954","17.0657",{"$nulls":3},"dolichol-linked oligosaccharide biosynthetic process;protein glycosylation in endoplasmic reticulum;response to calcium ion","alpha-1,3-mannosyltransferase activity;calcium-dependent protein binding;GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity;GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity;protein heterodimerization activity;protein N-terminus binding","cytoplasm;endoplasmic reticulum membrane;integral component of membrane;membrane;nucleus;perinuclear region of cytoplasm","Metabolic pathways;N-Glycan biosynthesis",null,null,1,1,1,"6.2","6.2","6.2","47.091",0,"11.261",41986000,9,"0.269101","0.756004","-0.490463","-0.736409","sp|Q9H553|ALG2_HUMAN","sp|Q9H553|ALG2_HUMAN",2602,"Q9H553","ALG2_HUMAN","Alpha-1,3/1,6-mannosyltransferase ALG2",null,"ALG2"]
["16.9916","16.4618","17.488","16.9464",{"$nulls":3},"ATP-dependent chromatin remodeling;cellular response to leukemia inhibitory factor;CENP-A containing nucleosome assembly;chromatin remodeling;chromatin silencing at rDNA;covalent chromatin modification;DNA-templated transcription, initiation;nucleosome assembly;nucleosome positioning;positive regulation of gene expression, epigenetic;positive regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter","ATP binding;ATPase activity;DNA binding;helicase activity;nucleosome binding","chromatin silencing complex;condensed chromosome;fibrillar center;nucleoplasm;nucleus;NURF complex;RSF complex",{"$nulls":3},3,3,3,4,4,4,"121.9",0,"6.2674",55660000,6,"0.488488","0.52421","-0.490486","-1.29479","sp|O60264|SMCA5_HUMAN","sp|O60264|SMCA5_HUMAN",283,"O60264","SMCA5_HUMAN","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5","WI/SNF-related matrix-associated actin-dependent regulator of chromatin A5","SMARCA5"]
["17.604","17.5867","18.4968","17.6754",{"$nulls":3},"cell-matrix adhesion;glutamate secretion;negative regulation of protein localization to plasma membrane;negative regulation of stress fiber assembly;neurotransmitter secretion;signal transduction","signal transducer activity","cytoplasm;cytosol;focal adhesion;presynaptic active zone",{"$nulls":3},9,9,9,12,12,12,"135.78",0,"23.739",131150000,32,"0.450084","0.55258","-0.490712","-1.19446","sp|Q13136|LIPA1_HUMAN;tr|H0YDW2|H0YDW2_HUMAN;tr|E9PJZ7|E9PJZ7_HUMAN;tr|H0YIJ4|H0YIJ4_HUMAN;tr|H0YHJ4|H0YHJ4_HUMAN;tr|H0YD72|H0YD72_HUMAN;tr|H0YEF9|H0YEF9_HUMAN;tr|M0QZB5|M0QZB5_HUMAN;tr|H0YHK3|H0YHK3_HUMAN;sp|O75335|LIPA4_HUMAN;tr|B1APN9|B1APN9_HUMAN;tr|G3V200|G3V200_HUMAN;sp|O75334|LIPA2_HUMAN","sp|Q13136|LIPA1_HUMAN",1525,"Q13136","LIPA1_HUMAN","Liprin-alpha-1",null,"PPFIA1"]
["19.1284","19.0451","19.8557","19.3",{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,"7.2","7.2","7.2","77.843",0,"22.945",157440000,17,"0.652556","0.390962","-0.491127","-1.74809","tr|A0A087WZ13|A0A087WZ13_HUMAN;tr|E9PAU2|E9PAU2_HUMAN;tr|K7EKR9|K7EKR9_HUMAN;sp|Q8IY67|RAVR1_HUMAN","tr|A0A087WZ13|A0A087WZ13_HUMAN;tr|E9PAU2|E9PAU2_HUMAN",3060,"A0A087WZ13","A0A087WZ13_HUMAN",null,null,"RAVER1"]
["18.5297","18.4435","19.2504","18.7061",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","hydrolase activity;structural constituent of ribosome","cell junction;mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,"9.7","9.7","9.7","31.705","0.001405","2.3041",64985000,4,"0.664943","0.38916","-0.49168","-1.78433","sp|Q9H2W6|RM46_HUMAN","sp|Q9H2W6|RM46_HUMAN",2584,"Q9H2W6","RM46_HUMAN","39S ribosomal protein L46, mitochondrial","46mt;RP-L46","MRPL46"]
["19.8003","19.603","20.4209","19.9669",{"$nulls":3},"seryl-tRNA aminoacylation","ATP binding;serine-tRNA ligase activity","cytoplasm",{"$nulls":3},3,3,3,"15.7","15.7","15.7","26.313",0,"16.264",117350000,16,"0.732803","0.348349","-0.492288","-1.98898","tr|B4DJM9|B4DJM9_HUMAN;tr|M0QWZ7|M0QWZ7_HUMAN;sp|Q9NP81|SYSM_HUMAN;tr|M0R2C6|M0R2C6_HUMAN;tr|M0R2H5|M0R2H5_HUMAN","tr|B4DJM9|B4DJM9_HUMAN;tr|M0QWZ7|M0QWZ7_HUMAN;sp|Q9NP81|SYSM_HUMAN;tr|M0R2C6|M0R2C6_HUMAN",2656,"B4DJM9","B4DJM9_HUMAN",null,null,"SARS2"]
["17.4863","17.4212","18.1035","17.7903",{"$nulls":4},"ATP binding;magnesium ion binding;phospholipid-translocating ATPase activity","integral component of membrane",{"$nulls":3},1,1,1,5,5,5,"22.783","0.0097656","1.6872",19024000,1,"1.04072","0.299442","-0.493156","-3.08332","tr|H7C0E8|H7C0E8_HUMAN;tr|A0A067XG54|A0A067XG54_HUMAN;sp|Q8NB49|AT11C_HUMAN","tr|H7C0E8|H7C0E8_HUMAN;tr|A0A067XG54|A0A067XG54_HUMAN;sp|Q8NB49|AT11C_HUMAN",2068,"H7C0E8","H7C0E8_HUMAN",null,null,"ATP11C"]
["15.3682","15.3019","16.0399","15.6189",{"$nulls":3},"cell activation involved in immune response;cellular response to virus;COPI coating of Golgi vesicle;endoplasmic reticulum-Golgi intermediate compartment organization;ER to Golgi vesicle-mediated transport;establishment of monopolar cell polarity;Golgi disassembly;Golgi organization;Golgi to endosome transport;neutrophil chemotaxis;post-Golgi vesicle-mediated transport;protein localization to endoplasmic reticulum exit site;protein localization to endoplasmic reticulum tubular network;protein localization to Golgi apparatus;protein transport;reactive oxygen species biosynthetic process;regulation of ARF protein signal transduction;regulation of mitotic cell cycle;regulation of protein localization to cell surface;retrograde transport, endosome to Golgi;retrograde vesicle-mediated transport, Golgi to ER;viral process","ARF guanyl-nucleotide exchange factor activity;guanyl-nucleotide exchange factor activity;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,5-bisphosphate binding","cell leading edge;cis-Golgi network;cytosol;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment;Golgi apparatus;Golgi membrane;Golgi stack;lipid droplet;membrane;mitochondrion;peroxisome;trans-Golgi network","Endocytosis",null,null,2,2,2,"1.9","1.9","1.9","206.44",0,"32.23",50728000,12,"0.835154","0.314521","-0.494401","-2.31969","sp|Q92538|GBF1_HUMAN","sp|Q92538|GBF1_HUMAN",2169,"Q92538","GBF1_HUMAN","Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1","FA-resistant GEF 1","GBF1"]
["19.5961","19.7924","20.3895","19.988",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding","cytosol;nucleus",{"$nulls":3},12,12,12,"24.8","24.8","24.8","70.839",0,"62.135",447140000,46,"0.803022","0.327879","-0.494515","-2.21277","tr|A0A0D9SFB3|A0A0D9SFB3_HUMAN;tr|A0A0D9SG12|A0A0D9SG12_HUMAN;sp|O00571|DDX3X_HUMAN;tr|A0A0D9SF53|A0A0D9SF53_HUMAN;sp|O15523|DDX3Y_HUMAN;tr|B4DLA0|B4DLA0_HUMAN;tr|A0A0J9YVQ7|A0A0J9YVQ7_HUMAN;tr|A0A0J9YYH6|A0A0J9YYH6_HUMAN;tr|C9J8G5|C9J8G5_HUMAN;tr|C9J081|C9J081_HUMAN;tr|A0A087WX09|A0A087WX09_HUMAN;tr|A0A087WVZ1|A0A087WVZ1_HUMAN","tr|A0A0D9SFB3|A0A0D9SFB3_HUMAN;tr|A0A0D9SG12|A0A0D9SG12_HUMAN;sp|O00571|DDX3X_HUMAN;tr|A0A0D9SF53|A0A0D9SF53_HUMAN;sp|O15523|DDX3Y_HUMAN",152,"A0A0D9SFB3","A0A0D9SFB3_HUMAN",null,null,"DDX3X"]
["14.1939","14.6766","16.1341","13.7255",{"$nulls":3},"apoptotic process;negative regulation of apoptotic process",null,"endomembrane system;intracellular;membrane",{"$nulls":3},1,1,1,"5.5","5.5","5.5","38.506","0.0081806","1.7313",5843000,1,"0.138966","0.888941","-0.494572","-0.402655","sp|Q9NQS1|AVEN_HUMAN","sp|Q9NQS1|AVEN_HUMAN",2670,"Q9NQS1","AVEN_HUMAN","Cell death regulator Aven",null,"AVEN"]
["20.9217","20.8552","21.6631","21.1033",{"$nulls":3},"cellular metal ion homeostasis;cristae formation;mitochondrial calcium ion homeostasis;mitochondrial calcium ion transmembrane transport;mitochondrial calcium release;protein hexamerization;protein homooligomerization","calcium ion binding;calcium:proton antiporter activity;ribosome binding","integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},7,7,7,"14.6","14.6","14.6","83.353",0,"67.829",726890000,43,"0.654953","0.391304","-0.494748","-1.75507","sp|O95202|LETM1_HUMAN","sp|O95202|LETM1_HUMAN",416,"O95202","LETM1_HUMAN","Mitochondrial proton/calcium exchanger protein {ECO:0000305}",null,"LETM1"]
["22.2369","22.3595","23.0247","22.5626",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},3,3,1,32,32,9,"11.477",0,"4.3481",411960000,9,"0.75943","0.337378","-0.495413","-2.07232","tr|I3L3P7|I3L3P7_HUMAN;sp|P62244|RS15A_HUMAN;tr|I3L246|I3L246_HUMAN;tr|H3BV27|H3BV27_HUMAN;tr|H3BT37|H3BT37_HUMAN;tr|I3L303|I3L303_HUMAN;tr|H3BVC7|H3BVC7_HUMAN","tr|I3L3P7|I3L3P7_HUMAN;sp|P62244|RS15A_HUMAN;tr|I3L246|I3L246_HUMAN",1293,"I3L3P7","I3L3P7_HUMAN",null,null,"RPS15A"]
["15.4094","14.5937","16.5165","14.4783",{"$nulls":3},"calcium ion transport into cytosol;G-protein coupled receptor signaling pathway;long-term synaptic potentiation;memory;platelet activation;positive regulation of cytosolic calcium ion concentration;protein heterooligomerization;protein homooligomerization;regulation of cardiac conduction;regulation of insulin secretion;response to calcium ion;sensory perception of bitter taste;sensory perception of sweet taste;sensory perception of umami taste","calcium ion binding;calcium-release channel activity;inositol 1,3,4,5 tetrakisphosphate binding;inositol 1,4,5 trisphosphate binding;inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;inositol hexakisphosphate binding;phosphatidylinositol binding","apical part of cell;brush border;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of plasma membrane;membrane;myelin sheath;neuronal cell body;nuclear outer membrane;nucleolus;nucleoplasm;plasma membrane;platelet dense tubular network membrane;receptor complex","Aldosterone synthesis and secretion;Alzheimer disease;Apelin signaling pathway;Apoptosis;Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholinergic synapse;Circadian entrainment;Cortisol synthesis and secretion;C-type lectin receptor signaling pathway;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Insulin secretion;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;NOD-like receptor signaling pathway;Oocyte meiosis;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Phosphatidylinositol signaling system;Platelet activation;Proteoglycans in cancer;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Taste transduction;Thyroid hormone synthesis;Vascular smooth muscle contraction",null,null,3,3,3,"1.3","1.3","1.3","304.1",0,"5.8801",61625000,10,"0.157566","0.868062","-0.495877","-0.451738","sp|Q14573|ITPR3_HUMAN","sp|Q14573|ITPR3_HUMAN",1631,"Q14573","ITPR3_HUMAN","Inositol 1,4,5-trisphosphate receptor type 3",null,"ITPR3"]
["16.8596","16.7761","17.4649","17.1639",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;regulation of translation","ribosomal small subunit binding;RNA binding;rRNA binding","cytosol;mitochondrial inner membrane;mitochondrion;nucleoplasm;plasma membrane;ribosome",{"$nulls":3},2,2,2,"3.9","3.9","3.9","78.549",0,"3.5039",48693000,6,"1.06379","0.303838","-0.496533","-3.1788","sp|Q96EY7|PTCD3_HUMAN","sp|Q96EY7|PTCD3_HUMAN",2266,"Q96EY7","PTCD3_HUMAN","Pentatricopeptide repeat domain-containing protein 3, mitochondrial",null,"PTCD3"]
["14.1456","14.2999","14.9459","14.4927",{"$nulls":3},"cerebellar Purkinje cell differentiation;C-terminal protein deglutamylation;eye photoreceptor cell differentiation;mitochondrion organization;neuromuscular process;olfactory bulb development;protein side chain deglutamylation","metallocarboxypeptidase activity;tubulin binding;zinc ion binding","cytoplasm;cytosol;intracellular membrane-bounded organelle;mitochondrion;nucleolus;nucleus",{"$nulls":3},1,1,1,1,1,1,"138.45",0,"4.4335",17489000,3,"0.760107","0.338561","-0.496546","-2.07446","sp|Q9UPW5|CBPC1_HUMAN;tr|J3KNS1|J3KNS1_HUMAN","sp|Q9UPW5|CBPC1_HUMAN;tr|J3KNS1|J3KNS1_HUMAN",2927,"Q9UPW5","CBPC1_HUMAN","Cytosolic carboxypeptidase 1",null,"AGTPBP1"]
["19.2236","19.236","20.194","19.2602",{"$nulls":4},"cytochrome-c oxidase activity","mitochondrial respiratory chain;mitochondrion;nucleolus",{"$nulls":3},2,2,2,38,38,38,"8.8399","0.0014055","2.3082",33802000,3,"0.399678","0.621005","-0.49732","-1.06508","tr|E5RJZ1|E5RJZ1_HUMAN;tr|H0YBD2|H0YBD2_HUMAN;sp|O14548|COX7R_HUMAN","tr|E5RJZ1|E5RJZ1_HUMAN;tr|H0YBD2|H0YBD2_HUMAN;sp|O14548|COX7R_HUMAN",159,"E5RJZ1","E5RJZ1_HUMAN",null,null,"COX7A2L"]
["26.0646","25.8932","26.7943","26.1585",{"$nulls":3},"animal organ regeneration;ATP biosynthetic process;canonical glycolysis;cellular response to insulin stimulus;liver development;neutrophil degranulation;programmed cell death;protein homotetramerization;pyruvate biosynthetic process;response to gravity;response to hypoxia;response to muscle inactivity;response to nutrient;skeletal muscle tissue regeneration","ADP binding;ATP binding;cadherin binding;identical protein binding;kinase activity;magnesium ion binding;MHC class II protein complex binding;potassium ion binding;pyruvate kinase activity;RNA binding;thyroid hormone binding","cilium;cytoplasm;cytosol;extracellular exosome;extracellular matrix;extracellular region;extracellular vesicle;ficolin-1-rich granule lumen;mitochondrion;myelin sheath;nucleus;pyruvate kinase complex;secretory granule lumen;vesicle","Biosynthesis of amino acids;Carbon metabolism;Central carbon metabolism in cancer;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;Human papillomavirus infection;Metabolic pathways;Purine metabolism;Pyruvate metabolism;Type II diabetes mellitus;Viral carcinogenesis",null,null,27,27,3,"58.6","58.6","7.3","57.936",0,"323.31",26768000000,272,"0.568761","0.468146","-0.497471","-1.51088","sp|P14618|KPYM_HUMAN;tr|B4DNK4|B4DNK4_HUMAN;tr|H3BQ34|H3BQ34_HUMAN;tr|H3BUW1|H3BUW1_HUMAN;tr|H3BTJ2|H3BTJ2_HUMAN;tr|H3BT25|H3BT25_HUMAN;tr|H3BU13|H3BU13_HUMAN;tr|H3BN34|H3BN34_HUMAN;tr|H3BQZ3|H3BQZ3_HUMAN","sp|P14618|KPYM_HUMAN;tr|B4DNK4|B4DNK4_HUMAN;tr|H3BQ34|H3BQ34_HUMAN",670,"P14618","KPYM_HUMAN","Pyruvate kinase PKM",null,"PKM"]
["16.8153","17.469","17.7723","17.507",{"$nulls":3},"glycoprotein catabolic process;N-acetylglucosamine metabolic process;protein deglycosylation;protein O-linked glycosylation","[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity;[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity;[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity;beta-N-acetylglucosaminidase activity;hyalurononglucosaminidase activity","cytosol;membrane;nucleus","Insulin resistance",null,null,2,2,2,"2.3","2.3","2.3","102.91","0.00075988","2.9008",76039000,4,"0.531865","0.496458","-0.497502","-1.41037","sp|O60502|OGA_HUMAN","sp|O60502|OGA_HUMAN",290,"O60502","OGA_HUMAN","Protein O-GlcNAcase {ECO:0000303|PubMed:11148210, ECO:0000303|PubMed:11788610}","GA {ECO:0000303|PubMed:20863279}","MGEA5"]
["20.0487","20.5329","20.7649","20.8121",{"$nulls":3},"cytoplasmic sequestering of NF-kappaB;mRNA transport;Ras protein signal transduction;stress granule assembly","mRNA binding;receptor signaling complex scaffold activity;RNA binding","cytoplasm;cytosol;intracellular ribonucleoprotein complex",{"$nulls":3},5,4,4,"13.5","11.8","11.8","54.12",0,"127.33",354820000,14,"0.751136","0.339196","-0.497673","-2.04617","sp|Q9UN86|G3BP2_HUMAN;tr|D6RGJ4|D6RGJ4_HUMAN;tr|D6RAC7|D6RAC7_HUMAN;tr|D6RB17|D6RB17_HUMAN;tr|D6R9X5|D6R9X5_HUMAN;tr|D6R9A4|D6R9A4_HUMAN;tr|D6RBM9|D6RBM9_HUMAN;tr|D6REX8|D6REX8_HUMAN;tr|D6RBR0|D6RBR0_HUMAN;tr|D6RE13|D6RE13_HUMAN;tr|D6RBW8|D6RBW8_HUMAN","sp|Q9UN86|G3BP2_HUMAN",2906,"Q9UN86","G3BP2_HUMAN","Ras GTPase-activating protein-binding protein 2","3BP-2","G3BP2"]
["21.1019","20.9388","21.6127","21.4237",{"$nulls":5},"cytosol;plasma membrane",{"$nulls":3},4,4,4,"31.7","31.7","31.7","17.603",0,"7.1423",252640000,25,"1.2403","0.317043","-0.497779","-3.98806","tr|H3BU16|H3BU16_HUMAN;tr|A6NGP5|A6NGP5_HUMAN;sp|Q9H910|HN1L_HUMAN;tr|H3BMT0|H3BMT0_HUMAN;tr|H3BTV5|H3BTV5_HUMAN;tr|H3BMV3|H3BMV3_HUMAN","tr|H3BU16|H3BU16_HUMAN;tr|A6NGP5|A6NGP5_HUMAN;sp|Q9H910|HN1L_HUMAN;tr|H3BMT0|H3BMT0_HUMAN;tr|H3BTV5|H3BTV5_HUMAN;tr|H3BMV3|H3BMV3_HUMAN",2617,"H3BU16","H3BU16_HUMAN",null,null,"JPT2"]
["17.9714","17.8377","18.5858","18.2189",{"$nulls":3},"apoptotic process;cell death;cytoplasmic sequestering of NF-kappaB;positive regulation of apoptotic process;positive regulation of cell death;positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;positive regulation of protein complex assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;regulation of cell adhesion;regulation of protein catabolic process","heat shock protein binding;NF-kappaB binding;protein domain specific binding;protein kinase binding;protein kinase regulator activity;ubiquitin binding;ubiquitin protein ligase binding","CD95 death-inducing signaling complex;cytosol;nuclear envelope;nucleus;perinuclear region of cytoplasm;VCP-NPL4-UFD1 AAA ATPase complex","Necroptosis",null,null,2,2,2,4,4,4,"73.953",0,"5.6034",81079000,5,"0.901187","0.299561","-0.497799","-2.54922","sp|Q9UNN5|FAF1_HUMAN;tr|B3KT28|B3KT28_HUMAN;tr|B1ANM7|B1ANM7_HUMAN","sp|Q9UNN5|FAF1_HUMAN;tr|B3KT28|B3KT28_HUMAN;tr|B1ANM7|B1ANM7_HUMAN",2915,"Q9UNN5","FAF1_HUMAN","FAS-associated factor 1","FAF1","FAF1"]
["18.7341","18.7597","19.3421","19.1482",{"$nulls":3},"negative regulation of phosphatase activity;protein complex assembly;rRNA metabolic process;rRNA transcription","RNA binding","condensed nuclear chromosome;cytoplasm;nucleolus;nucleoplasm",{"$nulls":3},4,4,4,"17.1","17.1","17.1","34.222",0,"9.8079",61162000,11,"1.43846","0.331016","-0.4982","-5.09449","sp|Q9BYG3|MK67I_HUMAN;tr|H7BZL0|H7BZL0_HUMAN;tr|C9J808|C9J808_HUMAN;tr|C9J6C5|C9J6C5_HUMAN","sp|Q9BYG3|MK67I_HUMAN;tr|H7BZL0|H7BZL0_HUMAN;tr|C9J808|C9J808_HUMAN;tr|C9J6C5|C9J6C5_HUMAN",2510,"Q9BYG3","MK67I_HUMAN","MKI67 FHA domain-interacting nucleolar phosphoprotein",null,"NIFK"]
["20.4945","20.3005","21.0834","20.7081",{"$nulls":3},"ATP hydrolysis coupled proton transport","proton-transporting ATPase activity, rotational mechanism","vacuolar proton-transporting V-type ATPase, V1 domain",{"$nulls":3},4,4,4,"14.9","14.9","14.9","51.57",0,"137.63",417650000,23,"0.84658","0.30911","-0.498242","-2.35844","tr|G3V126|G3V126_HUMAN;sp|Q9UI12|VATH_HUMAN","tr|G3V126|G3V126_HUMAN;sp|Q9UI12|VATH_HUMAN",2845,"G3V126","G3V126_HUMAN"]
["20.6317","20.465","21.2094","20.8839",{"$nulls":3},"acetyl-CoA biosynthetic process from pyruvate;cellular nitrogen compound metabolic process;glucose metabolic process;mitochondrial acetyl-CoA biosynthetic process from pyruvate;pyruvate metabolic process;regulation of acetyl-CoA biosynthetic process from pyruvate;tricarboxylic acid cycle","pyruvate dehydrogenase (acetyl-transferring) activity;pyruvate dehydrogenase (NAD+) activity;pyruvate dehydrogenase activity","mitochondrial matrix;mitochondrion;myelin sheath;nucleolus;nucleus;pyruvate dehydrogenase complex","Carbon metabolism;Central carbon metabolism in cancer;Citrate cycle (TCA cycle);Glucagon signaling pathway;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Pyruvate metabolism",null,null,7,7,7,"24.9","24.9","24.9","43.295",0,"55.736",343960000,26,"0.949134","0.295233","-0.498281","-2.7248","sp|P08559|ODPA_HUMAN;tr|Q5JPU3|Q5JPU3_HUMAN;tr|Q5JPU0|Q5JPU0_HUMAN;tr|Q5JPT9|Q5JPT9_HUMAN;tr|Q5JPU1|Q5JPU1_HUMAN;tr|Q5JPU2|Q5JPU2_HUMAN;sp|P29803|ODPAT_HUMAN","sp|P08559|ODPA_HUMAN",563,"P08559","ODPA_HUMAN","Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial",null,"PDHA1"]
["22.6408","22.4095","23.2106","22.8362",{"$nulls":3},"translation","structural constituent of ribosome","small ribosomal subunit",{"$nulls":3},3,3,3,"41.1","41.1","41.1","14.759",0,"103.33",498490000,30,"0.818589","0.322054","-0.498288","-2.2642","tr|K7EJ78|K7EJ78_HUMAN;tr|K7EQJ5|K7EQJ5_HUMAN;sp|P62841|RS15_HUMAN;tr|K7ELC2|K7ELC2_HUMAN;tr|S4R456|S4R456_HUMAN;tr|K7EM56|K7EM56_HUMAN;tr|A0A0B4J2B4|A0A0B4J2B4_HUMAN;tr|S4R417|S4R417_HUMAN","tr|K7EJ78|K7EJ78_HUMAN;tr|K7EQJ5|K7EQJ5_HUMAN;sp|P62841|RS15_HUMAN;tr|K7ELC2|K7ELC2_HUMAN;tr|S4R456|S4R456_HUMAN;tr|K7EM56|K7EM56_HUMAN;tr|A0A0B4J2B4|A0A0B4J2B4_HUMAN;tr|S4R417|S4R417_HUMAN",1319,"K7EJ78","K7EJ78_HUMAN",null,null,"RPS15"]
["16.3114",1,"17.3101",1,{"$nulls":3},"beta-catenin-TCF complex assembly;cellular response to DNA damage stimulus;histone H3-K4 methylation;post-translational protein modification;regulation of megakaryocyte differentiation;regulation of transcription, DNA-templated;response to estrogen;transcription, DNA-templated","histone-lysine N-methyltransferase activity;methylated histone binding;transcription regulatory region DNA binding","histone methyltransferase complex;MLL1 complex;MLL3/4 complex;nucleolus;nucleoplasm;nucleus;Set1C/COMPASS complex","Cushing syndrome",null,null,1,1,1,"2.2","2.2","2.2","59.152","0.00039017","3.1636",18163000,1,"0.013923","0.980555","-0.499334","-0.0446414","sp|Q15291|RBBP5_HUMAN","sp|Q15291|RBBP5_HUMAN",1689,"Q15291","RBBP5_HUMAN","Retinoblastoma-binding protein 5","BBP-5","RBBP5"]
["16.6576","16.7211","17.3528","17.0265",{"$nulls":3},"DNA double-strand break processing;double-strand break repair;double-strand break repair via homologous recombination;nucleic acid phosphodiester bond hydrolysis","3'-5' exonuclease activity;exodeoxyribonuclease I activity;nucleic acid binding;single-stranded DNA 3'-5' exodeoxyribonuclease activity","cytoplasm;nucleus",{"$nulls":3},1,1,1,"2.4","2.4","2.4","70.352",0,"5.6449",36170000,9,"1.02267","0.297693","-0.500288","-3.01011","sp|Q9NVH0|EXD2_HUMAN","sp|Q9NVH0|EXD2_HUMAN",2721,"Q9NVH0","EXD2_HUMAN","Exonuclease 3'-5' domain-containing protein 2 {ECO:0000312|HGNC:HGNC:20217}",null,"EXD2"]
["21.1307","21.3257","22.1388","21.3182",{"$nulls":3},"in utero embryonic development;protein transport;regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter","RNA binding","cytosol;nucleus",{"$nulls":3},6,6,6,"48.1","48.1","48.1","22.168",0,"119.36",303640000,37,"0.446958","0.554271","-0.500299","-1.18637","sp|P20290|BTF3_HUMAN;tr|H0Y9Y1|H0Y9Y1_HUMAN;tr|D6RDG3|D6RDG3_HUMAN","sp|P20290|BTF3_HUMAN;tr|H0Y9Y1|H0Y9Y1_HUMAN;tr|D6RDG3|D6RDG3_HUMAN",739,"P20290","BTF3_HUMAN","Transcription factor BTF3",null,"BTF3"]
["17.391","17.2498","17.9131","17.7289",{"$nulls":4},"oxidoreductase activity","integral component of membrane",{"$nulls":3},1,1,1,"3.9","3.9","3.9","33.524","0.0047765","2.033",31496000,5,"1.3031","0.333616","-0.500604","-4.31375","tr|A0A0C4DGQ8|A0A0C4DGQ8_HUMAN;sp|Q6IAN0|DRS7B_HUMAN","tr|A0A0C4DGQ8|A0A0C4DGQ8_HUMAN;sp|Q6IAN0|DRS7B_HUMAN",1868,"A0A0C4DGQ8","A0A0C4DGQ8_HUMAN",null,null,"DHRS7B"]
["18.5695","18.7895","19.1621","19.1985",{"$nulls":3},"double-strand break repair;female meiosis I;male meiosis I;mitotic spindle assembly checkpoint;oocyte maturation;oogenesis;reciprocal meiotic recombination;spermatid development;spermatogenesis;synaptonemal complex assembly;transcription from RNA polymerase II promoter","ATP binding;identical protein binding;transcription cofactor activity","male germ cell nucleus;nucleus",{"$nulls":3},4,4,4,12,12,12,"48.55",0,"17.505",119300000,7,"1.33549","0.335028","-0.500771","-4.49035","sp|Q15645|PCH2_HUMAN;tr|H0YAL2|H0YAL2_HUMAN","sp|Q15645|PCH2_HUMAN",1713,"Q15645","PCH2_HUMAN","Pachytene checkpoint protein 2 homolog",null,"TRIP13"]
["23.4424","23.2919","24.0217","23.7147",{"$nulls":3},"negative regulation of RNA splicing;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;mRNA binding;RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;membrane;nucleoplasm;small ribosomal subunit",{"$nulls":3},2,2,2,"20.9","20.9","20.9","13.015",0,"4.2359",687620000,16,"1.00275","0.294719","-0.501059","-2.93083","sp|P62854|RS26_HUMAN;sp|Q5JNZ5|RS26L_HUMAN","sp|P62854|RS26_HUMAN;sp|Q5JNZ5|RS26L_HUMAN",1322,"P62854","RS26_HUMAN","40S ribosomal protein S26",null,"RPS26"]
["15.6837","16.987","16.5401","17.1334",{"$nulls":3},"regulation of hair cycle",null,"cytoplasm",{"$nulls":3},2,2,2,"5.6","5.6","5.6","66.86","0.0010768","2.4187",35439000,6,"0.254715","0.769547","-0.50139","-0.700242","sp|Q8TE67|ES8L3_HUMAN","sp|Q8TE67|ES8L3_HUMAN",2123,"Q8TE67","ES8L3_HUMAN","Epidermal growth factor receptor kinase substrate 8-like protein 3","PS8-like protein 3","EPS8L3"]
["19.4002","20.503","20.9072","19.9995",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;cargo loading into COPII-coated vesicle;COPII vesicle coating;intracellular protein transport;mRNA transport;positive regulation of TOR signaling;sister chromatid cohesion","identical protein binding;structural molecule activity","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;extracellular exosome;GATOR2 complex;Golgi membrane;intracellular membrane-bounded organelle;lysosomal membrane;nuclear envelope;nuclear pore outer ring;nucleoplasm","mTOR signaling pathway;Protein processing in endoplasmic reticulum;RNA transport",null,null,4,4,4,"20.8","20.8","20.8","35.54",0,"28.553",182000000,13,"0.255633","0.768055","-0.501738","-0.702554","sp|P55735|SEC13_HUMAN;tr|A0A0C4DFR6|A0A0C4DFR6_HUMAN;tr|A8MXL6|A8MXL6_HUMAN","sp|P55735|SEC13_HUMAN;tr|A0A0C4DFR6|A0A0C4DFR6_HUMAN",1210,"P55735","SEC13_HUMAN","Protein SEC13 homolog {ECO:0000305}",null,"SEC13"]
["18.054","16.9261","18.8268","17.1578",{"$nulls":4},"ATP binding",{"$nulls":4},6,4,4,"15.3","9.6","9.6","59.196",0,"8.6199",100450000,11,"0.17556","0.845459","-0.502222","-0.498624","tr|D6RJ96|D6RJ96_HUMAN;sp|O95757|HS74L_HUMAN;tr|E9PDE8|E9PDE8_HUMAN","tr|D6RJ96|D6RJ96_HUMAN;sp|O95757|HS74L_HUMAN;tr|E9PDE8|E9PDE8_HUMAN",448,"D6RJ96","D6RJ96_HUMAN",null,null,"HSPA4L"]
["18.335","18.2007","19.1203","18.4202",{"$nulls":3},"amelogenesis;brown fat cell differentiation;cell adhesion mediated by integrin;cell-cell adhesion;cell-matrix adhesion;cell-substrate adhesion;cell-substrate junction assembly;cellular response to extracellular stimulus;cellular response to organic cyclic compound;digestive tract development;ectodermal cell differentiation;extracellular matrix organization;filopodium assembly;hemidesmosome assembly;integrin-mediated signaling pathway;leukocyte migration;nail development;negative regulation of extrinsic apoptotic signaling pathway;positive regulation of apoptotic process;positive regulation of cell migration;positive regulation of cell-cell adhesion;positive regulation of cell-substrate adhesion;positive regulation of GTPase activity;positive regulation of phosphorylation;positive regulation of transcription from RNA polymerase II promoter;renal system development;skin development","cadherin binding;insulin-like growth factor I binding;integrin binding;laminin binding;metal ion binding;neuregulin binding","basal plasma membrane;basement membrane;cell surface;cell-cell adherens junction;external side of plasma membrane;filopodium;focal adhesion;hemidesmosome;integrin alpha6-beta4 complex;plasma membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Cell adhesion molecules (CAMs);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Hematopoietic cell lineage;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);Pathways in cancer;PI3K-Akt signaling pathway;Regulation of actin cytoskeleton;Small cell lung cancer;Toxoplasmosis",null,null,9,9,9,"13.1","13.1","13.1","126.6",0,"28.451",284310000,40,"0.531614","0.495648","-0.502442","-1.40969","sp|P23229|ITA6_HUMAN;tr|H7BZ97|H7BZ97_HUMAN","sp|P23229|ITA6_HUMAN",772,"P23229","ITA6_HUMAN","Integrin alpha-6",null,"ITGA6"]
["17.3774","17.7801","18.5225","17.6399",{"$nulls":3},"rRNA processing;tRNA 5'-leader removal","ribonuclease P activity;RNA binding","microtubule organizing center;multimeric ribonuclease P complex;nucleoplasm;ribonuclease MRP complex","Ribosome biogenesis in eukaryotes;RNA transport",null,null,1,1,1,"7.5","7.5","7.5","20.632",0,"3.6146",14606000,5,"0.388192","0.634896","-0.502464","-1.0359","sp|Q9BUL9|RPP25_HUMAN","sp|Q9BUL9|RPP25_HUMAN",2458,"Q9BUL9","RPP25_HUMAN","Ribonuclease P protein subunit p25","Nase P protein subunit p25","RPP25"]
["22.6697","22.5948","23.3184","22.9512",{"$nulls":3},"androgen receptor signaling pathway;chaperone-mediated protein folding;copper ion transport;embryo implantation;male sex differentiation;negative regulation of microtubule polymerization;negative regulation of microtubule polymerization or depolymerization;negative regulation of neuron projection development;prostate gland development;protein complex localization;protein folding;regulation of cellular response to heat;steroid hormone receptor complex assembly","ATP binding;copper-dependent protein binding;FK506 binding;glucocorticoid receptor binding;GTP binding;heat shock protein binding;peptidyl-prolyl cis-trans isomerase activity;phosphoprotein binding;protein binding, bridging;RNA binding;tau protein binding","axonal growth cone;cytoplasm;cytosol;extracellular exosome;microtubule;mitochondrion;neuronal cell body;nucleoplasm;perinuclear region of cytoplasm;protein complex","Estrogen signaling pathway",null,null,15,15,15,"43.6","43.6","43.6","51.804",0,"165.84",2381600000,72,"0.93758","0.298705","-0.502529","-2.68177","sp|Q02790|FKBP4_HUMAN;tr|H0YFG2|H0YFG2_HUMAN;tr|F5H120|F5H120_HUMAN;tr|F5H1U3|F5H1U3_HUMAN","sp|Q02790|FKBP4_HUMAN",1432,"Q02790","FKBP4_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP4","PIase FKBP4","FKBP4"]
["17.4222","17.3873","17.9783","17.8371",{"$nulls":3},"microtubule cytoskeleton organization","structural molecule activity","microtubule cytoskeleton",{"$nulls":3},1,1,1,3,3,3,"81.964",0,"9.3678",59897000,6,"1.69293","0.344424","-0.502965","-6.91479","sp|Q96T17|MA7D2_HUMAN","sp|Q96T17|MA7D2_HUMAN",2359,"Q96T17","MA7D2_HUMAN","MAP7 domain-containing protein 2",null,"MAP7D2"]
["14.4951","14.7915","15.2608","15.0323",{"$nulls":3},"O-glycan processing;protein O-linked glycosylation","carbohydrate binding;metal ion binding;polypeptide N-acetylgalactosaminyltransferase activity","Golgi apparatus;Golgi membrane;integral component of membrane;perinuclear region of cytoplasm","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,1,1,1,"2.4","2.4","2.4","71.158","0.0010787","2.4307",8996500,2,"0.939624","0.298286","-0.503248","-2.68935","sp|Q8NCL4|GALT6_HUMAN","sp|Q8NCL4|GALT6_HUMAN",2083,"Q8NCL4","GALT6_HUMAN","Polypeptide N-acetylgalactosaminyltransferase 6",null,"GALNT6"]
["17.9657","18.2468","18.1538","19.0659",{"$nulls":9},1,1,1,"10.6","10.6","10.6","13.812",0,"5.8797",17243000,4,"0.395784","0.623678","-0.503582","-1.05518","tr|H3BU49|H3BU49_HUMAN;sp|Q9Y2Y0|AR2BP_HUMAN","tr|H3BU49|H3BU49_HUMAN;sp|Q9Y2Y0|AR2BP_HUMAN",2963,"H3BU49","H3BU49_HUMAN",null,null,"ARL2BP"]
["16.1816","16.504","16.7779","16.9157",{"$nulls":4},"RNA binding","cytoplasm;cytoplasmic stress granule;cytosol;membrane;nuclear body;nucleoplasm;nucleus;polysomal ribosome",{"$nulls":3},3,3,3,"9.2","9.2","9.2","76.12",0,"6.3622",33267000,3,"0.988485","0.298131","-0.504012","-2.87496","sp|Q7Z417|NUFP2_HUMAN","sp|Q7Z417|NUFP2_HUMAN",1951,"Q7Z417","NUFP2_HUMAN","Nuclear fragile X mental retardation-interacting protein 2",null,"NUFIP2"]
["18.4579","17.9583","18.6662","18.7581",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;response to alkaloid;response to toxic substance;RNA splicing","ATP binding;ATP-dependent RNA helicase activity;double-stranded RNA binding;RNA binding;RNA helicase activity","cytoplasm;nuclear speck;nucleolus;nucleoplasm;nucleus;U12-type spliceosomal complex","Spliceosome",null,null,5,5,5,"8.1","8.1","8.1","90.932",0,"20.874",135140000,14,"0.731279","0.348299","-0.504028","-1.98427","sp|O43143|DHX15_HUMAN","sp|O43143|DHX15_HUMAN",227,"O43143","DHX15_HUMAN","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15",null,"DHX15"]
["26.8119","26.7125","27.4317","27.1023",{"$nulls":3},"glycolytic process;lactate metabolic process;NAD metabolic process;positive regulation of apoptotic process;post-embryonic animal organ development;pyruvate metabolic process;response to cAMP;response to drug;response to estrogen;response to glucose;response to hydrogen peroxide;response to hypoxia;response to nutrient;substantia nigra development","cadherin binding;identical protein binding;kinase binding;L-lactate dehydrogenase activity;NAD binding","cytosol;extracellular exosome;membrane;nucleus","Central carbon metabolism in cancer;Cysteine and methionine metabolism;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism",null,null,16,16,15,"57.5","57.5","53.9","36.688",0,"189.82",23270000000,122,"1.00369","0.29525","-0.504765","-2.93453","sp|P00338|LDHA_HUMAN;tr|F5GXY2|F5GXY2_HUMAN;tr|F5GYU2|F5GYU2_HUMAN;tr|F5GXH2|F5GXH2_HUMAN;tr|F5H5J4|F5H5J4_HUMAN;tr|F5H6W8|F5H6W8_HUMAN;tr|F5GZQ4|F5GZQ4_HUMAN;tr|F5H8H6|F5H8H6_HUMAN;tr|F5GXC7|F5GXC7_HUMAN;tr|F5GWW2|F5GWW2_HUMAN;tr|F5GXU1|F5GXU1_HUMAN","sp|P00338|LDHA_HUMAN",462,"P00338","LDHA_HUMAN","L-lactate dehydrogenase A chain","DH-A","LDHA"]
["24.1337","24.046","24.7839","24.4067",{"$nulls":3},"aging;cellular response to brain-derived neurotrophic factor stimulus;glial cell proliferation;hematopoietic progenitor cell differentiation;neutrophil degranulation;peptidyl-diphthamide biosynthetic process from peptidyl-histidine;positive regulation of cytoplasmic translation;positive regulation of translation;protein methylation;response to drug;response to endoplasmic reticulum stress;response to estradiol;response to ethanol;response to folic acid;response to hydrogen peroxide;response to ischemia;skeletal muscle cell differentiation;skeletal muscle contraction;translational elongation","5S rRNA binding;actin filament binding;cadherin binding;GTP binding;GTPase activity;p53 binding;protein kinase binding;ribosome binding;RNA binding;translation elongation factor activity","aggresome;cytoplasm;cytosol;extracellular exosome;extracellular matrix;extracellular region;ficolin-1-rich granule lumen;intracellular ribonucleoprotein complex;membrane;membrane raft;nucleus;plasma membrane;polysomal ribosome;secretory granule lumen","AMPK signaling pathway;Oxytocin signaling pathway",null,null,33,33,32,"46.9","46.9","45.7","95.337",0,"323.31",11381000000,308,"0.918244","0.293321","-0.505447","-2.61078","sp|P13639|EF2_HUMAN;tr|M0R0I6|M0R0I6_HUMAN;tr|K7EJ74|K7EJ74_HUMAN;tr|K7EP67|K7EP67_HUMAN","sp|P13639|EF2_HUMAN",658,"P13639","EF2_HUMAN","Elongation factor 2","F-2","EEF2"]
["23.0158","22.8133","23.6021","23.2379",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;interleukin-12-mediated signaling pathway;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;regulation of macrophage apoptotic process;scaRNA localization to Cajal body;toxin transport;translocation of peptides or proteins into host cell cytoplasm;tubulin complex assembly","ATP binding;protein binding involved in protein folding;RNA binding;ubiquitin protein ligase binding;unfolded protein binding","acrosomal vesicle;cell body;centrosome;chaperonin-containing T-complex;cytosol;extracellular exosome;Golgi apparatus;microtubule;myelin sheath;nuclear heterochromatin;pericentriolar material;zona pellucida receptor complex",{"$nulls":3},19,19,19,"49.3","49.3","49.3","60.343",0,"250.27",3154000000,130,"0.866308","0.30267","-0.505482","-2.42628","sp|P17987|TCPA_HUMAN;tr|E7EQR6|E7EQR6_HUMAN;tr|E7ERF2|E7ERF2_HUMAN;tr|F5H282|F5H282_HUMAN;tr|F5H136|F5H136_HUMAN;tr|F5H676|F5H676_HUMAN;tr|F5H726|F5H726_HUMAN;tr|F5GZI8|F5GZI8_HUMAN;tr|F5GZ03|F5GZ03_HUMAN;tr|F5GYL4|F5GYL4_HUMAN;tr|F5H7Y1|F5H7Y1_HUMAN","sp|P17987|TCPA_HUMAN;tr|E7EQR6|E7EQR6_HUMAN;tr|E7ERF2|E7ERF2_HUMAN;tr|F5H282|F5H282_HUMAN",715,"P17987","TCPA_HUMAN","T-complex protein 1 subunit alpha","CP-1-alpha","TCP1"]
["16.4224","16.2676","17.0607","16.6405",{"$nulls":3},"'de novo' pyrimidine nucleobase biosynthetic process;'de novo' UMP biosynthetic process;female pregnancy;lactation;positive regulation of apoptotic process;pyrimidine nucleoside biosynthetic process;regulation of mitochondrial fission;response to caffeine;response to drug;response to L-arginine;response to starvation","dihydroorotate dehydrogenase activity;drug binding;FMN binding;ubiquinone binding","cytosol;integral component of membrane;mitochondrial inner membrane;mitochondrion;neuronal cell body;nucleoplasm","Metabolic pathways;Pyrimidine metabolism",null,null,2,2,2,"8.1","8.1","8.1","42.867","0.0037671","2.0544",22114000,2,"0.816728","0.322082","-0.50558","-2.25801","sp|Q02127|PYRD_HUMAN;tr|I3NI32|I3NI32_HUMAN","sp|Q02127|PYRD_HUMAN;tr|I3NI32|I3NI32_HUMAN",1425,"Q02127","PYRD_HUMAN","Dihydroorotate dehydrogenase (quinone), mitochondrial","HOdehase","DHODH"]
["18.7372","18.7345","19.2528","19.2308",{"$nulls":3},"cholesterol biosynthetic process;hair follicle development;labyrinthine layer blood vessel development;smoothened signaling pathway","3-beta-hydroxy-delta5-steroid dehydrogenase activity;4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity;4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity;C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity;sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;lipid droplet","Metabolic pathways;Steroid biosynthesis",null,null,3,3,3,"12.1","12.1","12.1","41.9",0,"82.794",148420000,14,"3.31894","0.447","-0.505943","-45.6364","sp|Q15738|NSDHL_HUMAN;tr|C9JDR0|C9JDR0_HUMAN","sp|Q15738|NSDHL_HUMAN;tr|C9JDR0|C9JDR0_HUMAN",1719,"Q15738","NSDHL_HUMAN","Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating",null,"NSDHL"]
["19.0092","19.2962","20.1807","19.1369",{"$nulls":3},"DNA duplex unwinding;double-strand break repair;multicellular organism development;nucleic acid phosphodiester bond hydrolysis;protein localization to cytoplasmic stress granule;regulation of transcription, DNA-templated;regulation of translational initiation;response to exogenous dsRNA;response to virus;RNA secondary structure unwinding;spliceosomal complex assembly;transcription, DNA-templated;tRNA splicing, via endonucleolytic cleavage and ligation","ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;chromatin binding;DNA binding;DNA/RNA helicase activity;double-stranded RNA binding;exonuclease activity;nuclease activity;poly(A) binding;RNA binding;RNA helicase activity;transcription cofactor activity","cleavage body;cytoplasm;cytoplasmic stress granule;cytosol;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;tRNA-splicing ligase complex",{"$nulls":3},10,10,10,"19.3","19.3","19.3","82.431",0,"14.218",234690000,15,"0.348271","0.687201","-0.506108","-0.935066","sp|Q92499|DDX1_HUMAN;tr|F1T0B3|F1T0B3_HUMAN;tr|A0A087X2G1|A0A087X2G1_HUMAN","sp|Q92499|DDX1_HUMAN;tr|F1T0B3|F1T0B3_HUMAN;tr|A0A087X2G1|A0A087X2G1_HUMAN",2163,"Q92499","DDX1_HUMAN","ATP-dependent RNA helicase DDX1",null,"DDX1"]
["19.8343","19.9415","20.3916","20.3963",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome","Ribosome",null,null,1,1,1,"10.9","10.9","10.9","10.165",0,"6.7929",51743000,4,"1.95629","0.401115","-0.506116","-9.43012","sp|Q9BQ48|RM34_HUMAN;tr|M0R226|M0R226_HUMAN","sp|Q9BQ48|RM34_HUMAN;tr|M0R226|M0R226_HUMAN",2411,"Q9BQ48","RM34_HUMAN","39S ribosomal protein L34, mitochondrial","34mt;RP-L34","MRPL34"]
["19.0623","19.2189","19.7702","19.5249",{"$nulls":3},"plasma membrane organization;regulation of actin cytoskeleton organization","cytoskeletal adaptor activity",{"$nulls":4},1,1,1,"20.7","20.7","20.7","6.7425",0,"4.3267",31807000,5,"1.13392","0.314085","-0.506912","-3.48294","tr|I3L2J6|I3L2J6_HUMAN;tr|I3L113|I3L113_HUMAN;tr|I3L3C5|I3L3C5_HUMAN;tr|I3L526|I3L526_HUMAN;tr|I3L125|I3L125_HUMAN;tr|I3L0M4|I3L0M4_HUMAN;tr|I3L3J7|I3L3J7_HUMAN;tr|I3L327|I3L327_HUMAN;tr|I3L1C8|I3L1C8_HUMAN;tr|I3L2M4|I3L2M4_HUMAN;sp|Q9UQB8|BAIP2_HUMAN;tr|I3L4C2|I3L4C2_HUMAN","tr|I3L2J6|I3L2J6_HUMAN;tr|I3L113|I3L113_HUMAN;tr|I3L3C5|I3L3C5_HUMAN;tr|I3L526|I3L526_HUMAN;tr|I3L125|I3L125_HUMAN;tr|I3L0M4|I3L0M4_HUMAN;tr|I3L3J7|I3L3J7_HUMAN;tr|I3L327|I3L327_HUMAN;tr|I3L1C8|I3L1C8_HUMAN;tr|I3L2M4|I3L2M4_HUMAN;sp|Q9UQB8|BAIP2_HUMAN;tr|I3L4C2|I3L4C2_HUMAN",2931,"I3L2J6","I3L2J6_HUMAN",null,null,"BAIAP2"]
["15.0529","15.1427","15.7041","15.506",{"$nulls":3},"intracellular estrogen receptor signaling pathway;regulation of transcription, DNA-templated;RNA metabolic process;RNA processing;RNA secondary structure unwinding;transcription, DNA-templated","ATP binding;ATP-dependent RNA helicase activity;estrogen receptor binding;receptor binding;RNA binding;transcription corepressor activity","cytoplasm;Golgi apparatus;membrane;nucleolus;nucleus",{"$nulls":3},1,1,1,"1.2","1.2","1.2","98.594",0,"4.1388",16217000,1,"1.36655","0.331629","-0.507274","-4.66558","sp|Q8TDD1|DDX54_HUMAN","sp|Q8TDD1|DDX54_HUMAN",2120,"Q8TDD1","DDX54_HUMAN","ATP-dependent RNA helicase DDX54",null,"DDX54"]
["23.2383","23.5781","24.0523","23.7789",{"$nulls":3},"actomyosin structure organization","actin binding;calmodulin binding","cytoskeleton",{"$nulls":3},9,9,9,"37.2","37.2","37.2","32.616",0,"113.78",2231600000,61,"0.837252","0.314866","-0.507378","-2.32678","tr|B4DDF4|B4DDF4_HUMAN;sp|Q99439|CNN2_HUMAN;tr|B4DUT8|B4DUT8_HUMAN;tr|A0A087X271|A0A087X271_HUMAN;tr|A0A087X1X5|A0A087X1X5_HUMAN;tr|H3BVI6|H3BVI6_HUMAN;tr|K7ES69|K7ES69_HUMAN;tr|H3BQH0|H3BQH0_HUMAN;tr|A0A087WV51|A0A087WV51_HUMAN;tr|U3KPS3|U3KPS3_HUMAN;sp|Q15417|CNN3_HUMAN","tr|B4DDF4|B4DDF4_HUMAN;sp|Q99439|CNN2_HUMAN;tr|B4DUT8|B4DUT8_HUMAN;tr|A0A087X271|A0A087X271_HUMAN;tr|A0A087X1X5|A0A087X1X5_HUMAN;tr|H3BVI6|H3BVI6_HUMAN",2370,"B4DDF4","B4DDF4_HUMAN","Calponin {ECO:0000256|RuleBase:RU361224}",null,"CNN2"]
["21.762","21.5144","22.874","21.4173",{"$nulls":3},"proteasome-mediated ubiquitin-dependent protein catabolic process","threonine-type endopeptidase activity","proteasome core complex, beta-subunit complex",{"$nulls":3},4,4,4,"43.4","43.4","43.4","16.161",0,"26.007",360890000,21,"0.249371","0.776487","-0.507421","-0.686786","tr|A0A087WUL2|A0A087WUL2_HUMAN;sp|P49720|PSB3_HUMAN;tr|A0A087WXQ8|A0A087WXQ8_HUMAN;tr|A0A087WY10|A0A087WY10_HUMAN","tr|A0A087WUL2|A0A087WUL2_HUMAN;sp|P49720|PSB3_HUMAN;tr|A0A087WXQ8|A0A087WXQ8_HUMAN;tr|A0A087WY10|A0A087WY10_HUMAN",1086,"A0A087WUL2","A0A087WUL2_HUMAN",null,null,"PSMB3"]
["17.2922","16.8747","17.7441","17.4389",{"$nulls":3},"actin polymerization or depolymerization",{"$nulls":5},2,2,2,"4.6","4.6","4.6","52.789",0,"12.972",33826000,16,"0.72497","0.353863","-0.508057","-1.96481","tr|E7EW77|E7EW77_HUMAN;tr|E7EP65|E7EP65_HUMAN;tr|A0A0C4DG21|A0A0C4DG21_HUMAN;tr|F8WAL6|F8WAL6_HUMAN;sp|Q9NYB9|ABI2_HUMAN;tr|E7EUA1|E7EUA1_HUMAN;tr|F8WAU3|F8WAU3_HUMAN;tr|F8WCD7|F8WCD7_HUMAN;tr|F8WAZ8|F8WAZ8_HUMAN;tr|F8WBL5|F8WBL5_HUMAN;tr|F8WEB9|F8WEB9_HUMAN;tr|H7C3Q7|H7C3Q7_HUMAN;tr|H0Y6B5|H0Y6B5_HUMAN;tr|B7Z836|B7Z836_HUMAN;tr|E9PEZ7|E9PEZ7_HUMAN","tr|E7EW77|E7EW77_HUMAN;tr|E7EP65|E7EP65_HUMAN;tr|A0A0C4DG21|A0A0C4DG21_HUMAN;tr|F8WAL6|F8WAL6_HUMAN;sp|Q9NYB9|ABI2_HUMAN;tr|E7EUA1|E7EUA1_HUMAN;tr|F8WAU3|F8WAU3_HUMAN;tr|F8WCD7|F8WCD7_HUMAN;tr|F8WAZ8|F8WAZ8_HUMAN;tr|F8WBL5|F8WBL5_HUMAN;tr|F8WEB9|F8WEB9_HUMAN;tr|H7C3Q7|H7C3Q7_HUMAN;tr|H0Y6B5|H0Y6B5_HUMAN;tr|B7Z836|B7Z836_HUMAN;tr|E9PEZ7|E9PEZ7_HUMAN",2748,"E7EW77","E7EW77_HUMAN",null,null,"ABI2"]
["21.2291","20.5368","21.7722","21.0138",{"$nulls":3},"cellular protein metabolic process;post-translational protein modification","calcium ion binding","endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular region;Golgi apparatus;melanosome;membrane;sarcoplasmic reticulum lumen",{"$nulls":3},7,7,7,"30.5","30.5","30.5","37.106",0,"29.907",403990000,28,"0.371405","0.654478","-0.510058","-0.993393","sp|O43852|CALU_HUMAN;tr|H0Y875|H0Y875_HUMAN","sp|O43852|CALU_HUMAN;tr|H0Y875|H0Y875_HUMAN",273,"O43852","CALU_HUMAN","Calumenin",null,"CALU"]
["20.0135","19.9117","20.8875","20.0583",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;neutrophil degranulation;retrograde vesicle-mediated transport, Golgi to ER;viral process","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;ficolin-1-rich granule membrane;Golgi apparatus;Golgi membrane;Golgi-associated vesicle;intracellular membrane-bounded organelle;membrane;plasma membrane;secretory granule membrane;tertiary granule membrane;transport vesicle",{"$nulls":3},14,14,14,"21.4","21.4","21.4","107.14",0,"32.481",700970000,49,"0.460579","0.543647","-0.510324","-1.22171","sp|P53618|COPB_HUMAN;tr|E9PP73|E9PP73_HUMAN;tr|E9PP63|E9PP63_HUMAN;tr|E9PKQ1|E9PKQ1_HUMAN","sp|P53618|COPB_HUMAN",1181,"P53618","COPB_HUMAN","Coatomer subunit beta",null,"COPB1"]
["24.1035","24.4546","24.9338","24.6461",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;cytosolic ribosome;membrane;nucleus","Ribosome",null,null,5,5,5,"25.6","25.6","25.6","24.261",0,"111.29",2459200000,34,"0.814685","0.32102","-0.510902","-2.25123","sp|P26373|RL13_HUMAN;tr|J3QSB4|J3QSB4_HUMAN;tr|H3BTH3|H3BTH3_HUMAN","sp|P26373|RL13_HUMAN;tr|J3QSB4|J3QSB4_HUMAN",810,"P26373","RL13_HUMAN","60S ribosomal protein L13",null,"RPL13"]
["18.9957","19.0441","19.7733","19.2892",{"$nulls":3},"cell cycle;cell proliferation;extrinsic apoptotic signaling pathway in absence of ligand;insulin receptor signaling pathway;regulation of glucose import;regulation of protein localization to plasma membrane;signal transduction","identical protein binding;protein kinase B binding","cytoplasm;cytosol;early endosome;early endosome membrane;endosome membrane;extracellular exosome;nucleus;vesicle membrane","Colorectal cancer;Longevity regulating pathway;Pathways in cancer",null,null,5,5,5,"12.8","12.8","12.8","79.663",0,"16.476",244550000,20,"0.768794","0.337448","-0.511386","-2.10206","sp|Q9UKG1|DP13A_HUMAN;tr|C9K0C4|C9K0C4_HUMAN","sp|Q9UKG1|DP13A_HUMAN",2869,"Q9UKG1","DP13A_HUMAN","DCC-interacting protein 13-alpha","ip13-alpha","APPL1"]
["25.697","26.85","27.1647","26.4054",{"$nulls":3},"cytoplasmic sequestering of protein;hippo signaling;MAPK cascade;membrane organization;negative regulation of G-protein coupled receptor protein signaling pathway;negative regulation of protein dephosphorylation;negative regulation of transcription, DNA-templated;positive regulation of catalytic activity;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein heterooligomerization;protein targeting;regulation of mRNA stability;viral process","cadherin binding;enzyme binding;histone deacetylase binding;identical protein binding;phosphoprotein binding;phosphoserine residue binding;protein complex binding;protein C-terminus binding;protein domain specific binding;transcription corepressor activity","cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;focal adhesion;melanosome;membrane;mitochondrion;nucleus;perinuclear region of cytoplasm;protein complex;transcriptional repressor complex","Cell cycle;Hepatitis B;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,14,11,8,"64.6","57.3","47.2","28.082",0,"323.31",12567000000,127,"0.270971","0.756762","-0.511565","-0.741106","sp|P31946|1433B_HUMAN;tr|Q4VY20|Q4VY20_HUMAN;tr|Q4VY19|Q4VY19_HUMAN;tr|A0A0J9YWE8|A0A0J9YWE8_HUMAN;tr|A0A0J9YWZ2|A0A0J9YWZ2_HUMAN","sp|P31946|1433B_HUMAN",896,"P31946","1433B_HUMAN","14-3-3 protein beta/alpha",null,"YWHAB"]
["17.9905","17.849","19.0033","17.8605",{"$nulls":4},"actin binding;ATP binding;motor activity","myosin complex",{"$nulls":3},1,1,1,"10.2","10.2","10.2","13.206","0.0010823","2.4835",13776000,2,"0.330126","0.702789","-0.512136","-0.889467","tr|M0QXU2|M0QXU2_HUMAN;tr|H0YLE5|H0YLE5_HUMAN;sp|O00160|MYO1F_HUMAN;sp|Q12965|MYO1E_HUMAN","tr|M0QXU2|M0QXU2_HUMAN;tr|H0YLE5|H0YLE5_HUMAN;sp|O00160|MYO1F_HUMAN;sp|Q12965|MYO1E_HUMAN",120,"M0QXU2","M0QXU2_HUMAN",null,null,"MYO1F"]
["22.2391","22.0911","22.6978","22.6589",{"$nulls":3},"protein folding","ATP binding;unfolded protein binding","cytosol;plasma membrane",{"$nulls":3},13,13,13,36,36,36,"55.674",0,"132.11",1584100000,65,"1.66758","0.338112","-0.513271","-6.70965","tr|B4DUR8|B4DUR8_HUMAN;sp|P49368|TCPG_HUMAN;tr|Q5SZX6|Q5SZX6_HUMAN;tr|Q5SZW8|Q5SZW8_HUMAN;tr|E9PRC8|E9PRC8_HUMAN;tr|E9PQ35|E9PQ35_HUMAN;tr|E9PM09|E9PM09_HUMAN;tr|Q5SZX9|Q5SZX9_HUMAN","tr|B4DUR8|B4DUR8_HUMAN;sp|P49368|TCPG_HUMAN",1074,"B4DUR8","B4DUR8_HUMAN","T-complex protein 1 subunit gamma {ECO:0000256|RuleBase:RU004191}",null,"CCT3"]
["17.2305","16.8562","18.0217","17.0917",{"$nulls":3},"endocytosis",{"$nulls":5},1,1,1,"1.8","1.8","1.8","64.071","0.0050505","1.9254",48808000,5,"0.383517","0.636538","-0.51332","-1.02404","tr|B7ZL14|B7ZL14_HUMAN;tr|H0Y7W6|H0Y7W6_HUMAN;sp|Q96RU3|FNBP1_HUMAN","tr|B7ZL14|B7ZL14_HUMAN;tr|H0Y7W6|H0Y7W6_HUMAN;sp|Q96RU3|FNBP1_HUMAN",2350,"B7ZL14","B7ZL14_HUMAN"]
["20.576","20.8729","21.5294","20.9472",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;barbed-end actin filament capping;blood coagulation;ER to Golgi vesicle-mediated transport;innate immune response;movement of cell or subcellular component;protein complex assembly","actin binding","actin cytoskeleton;brush border;cortical cytoskeleton;cytosol;extracellular exosome;extracellular region;F-actin capping protein complex;membrane","Endocytosis",null,null,7,6,6,"38.1","34.6","34.6","32.949",0,"23.005",297420000,26,"0.591009","0.447043","-0.513845","-1.57259","sp|P47755|CAZA2_HUMAN;tr|C9JUG7|C9JUG7_HUMAN;tr|F8W9N7|F8W9N7_HUMAN;tr|A0A0D9SET8|A0A0D9SET8_HUMAN;tr|F8WED3|F8WED3_HUMAN","sp|P47755|CAZA2_HUMAN;tr|C9JUG7|C9JUG7_HUMAN;tr|F8W9N7|F8W9N7_HUMAN;tr|A0A0D9SET8|A0A0D9SET8_HUMAN",1044,"P47755","CAZA2_HUMAN","F-actin-capping protein subunit alpha-2",null,"CAPZA2"]
["13.2737","13.2627","14.1224","13.4419",{"$nulls":3},"small GTPase mediated signal transduction","GTPase activator activity;guanyl-nucleotide exchange factor activity","intracellular",{"$nulls":3},2,2,2,"1.7","1.7","1.7","158.93","0.0011128","2.7408",45038000,3,"0.568552","0.467805","-0.513963","-1.51031","tr|H0Y7H7|H0Y7H7_HUMAN;sp|Q8N1I0|DOCK4_HUMAN;tr|H0Y599|H0Y599_HUMAN;tr|F5GXW1|F5GXW1_HUMAN","tr|H0Y7H7|H0Y7H7_HUMAN;sp|Q8N1I0|DOCK4_HUMAN;tr|H0Y599|H0Y599_HUMAN;tr|F5GXW1|F5GXW1_HUMAN",2039,"H0Y7H7","H0Y7H7_HUMAN",null,null,"DOCK4"]
["22.7958","22.589","23.5015","22.9126",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;actin filament network formation;actin filament organization;focal adhesion assembly;negative regulation of cellular component movement;platelet degranulation;platelet formation;platelet morphogenesis;regulation of apoptotic process","actin filament binding;calcium ion binding;double-stranded RNA binding;integrin binding;ion channel binding;ligand-dependent nuclear receptor transcription coactivator activity;protein homodimerization activity;vinculin binding","brush border;cell projection;cell-cell junction;cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;fascia adherens;focal adhesion;intracellular;plasma membrane;platelet alpha granule lumen;pseudopodium;ruffle;stress fiber;Z disc","Adherens junction;Amoebiasis;Focal adhesion;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Systemic lupus erythematosus;Tight junction;Viral carcinogenesis",null,null,35,24,24,"56.7","41.7","41.7","103.06",0,"323.31",3892900000,169,"0.61812","0.423813","-0.514684","-1.64899","sp|P12814|ACTN1_HUMAN;tr|H9KV75|H9KV75_HUMAN;tr|G3V2N5|G3V2N5_HUMAN;tr|H7C5W8|H7C5W8_HUMAN;tr|H0YJW3|H0YJW3_HUMAN;tr|H0YJ11|H0YJ11_HUMAN;tr|G3V2W4|G3V2W4_HUMAN;sp|P35609|ACTN2_HUMAN;tr|G3V5M4|G3V5M4_HUMAN;sp|Q08043|ACTN3_HUMAN;tr|A0A087WSZ2|A0A087WSZ2_HUMAN;tr|G3V2X9|G3V2X9_HUMAN;tr|G3V2E8|G3V2E8_HUMAN;tr|F6THM6|F6THM6_HUMAN;tr|G3V380|G3V380_HUMAN","sp|P12814|ACTN1_HUMAN;tr|H9KV75|H9KV75_HUMAN",649,"P12814","ACTN1_HUMAN","Alpha-actinin-1",null,"ACTN1"]
["20.1593","20.0771","21.0104","20.2558",{"$nulls":3},"carnitine biosynthetic process;cellular response to leukemia inhibitory factor;cellular response to tetrahydrofolate;dTMP biosynthetic process;folic acid metabolic process;glycine biosynthetic process from serine;glycine metabolic process;L-serine catabolic process;L-serine metabolic process;negative regulation of translation;protein homotetramerization;protein tetramerization;purine nucleobase biosynthetic process;tetrahydrofolate interconversion;tetrahydrofolate metabolic process","glycine hydroxymethyltransferase activity;identical protein binding;L-allo-threonine aldolase activity;mRNA 5'-UTR binding;protein homodimerization activity;pyridoxal phosphate binding;serine binding;translation repressor activity, nucleic acid binding","cytosol;extracellular exosome;mitochondrion;nucleus","Antifolate resistance;Biosynthesis of amino acids;Carbon metabolism;Glycine, serine and threonine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;One carbon pool by folate",null,null,9,8,8,"22.4","19.5","19.5","53.082",0,"21.028",409750000,32,"0.511857","0.512318","-0.514914","-1.35673","sp|P34896|GLYC_HUMAN;tr|J3KRK5|J3KRK5_HUMAN;tr|J3KRZ5|J3KRZ5_HUMAN;tr|G3V2D2|G3V2D2_HUMAN","sp|P34896|GLYC_HUMAN",915,"P34896","GLYC_HUMAN","Serine hydroxymethyltransferase, cytosolic","HMT","SHMT1"]
["20.2349","19.8292","20.2","20.8944",{"$nulls":9},1,1,1,"21.5","21.5","21.5","7.3235","0.0010941","2.552",71403000,5,"0.48328","0.522926","-0.515121","-1.28108","tr|D6RC06|D6RC06_HUMAN;tr|D6REP8|D6REP8_HUMAN;tr|D6RE99|D6RE99_HUMAN;tr|D6RD60|D6RD60_HUMAN;sp|P49773|HINT1_HUMAN","tr|D6RC06|D6RC06_HUMAN;tr|D6REP8|D6REP8_HUMAN;tr|D6RE99|D6RE99_HUMAN;tr|D6RD60|D6RD60_HUMAN;sp|P49773|HINT1_HUMAN",1095,"D6RC06","D6RC06_HUMAN",null,null,"HINT1"]
["19.7525","19.2956","20.3188","19.7599",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;pancreatic juice secretion;retrograde vesicle-mediated transport, Golgi to ER","hormone activity;structural molecule activity","COPI vesicle coat;cytoplasm;cytosol;endoplasmic reticulum membrane;extracellular exosome;extracellular space;Golgi membrane;membrane;transport vesicle",{"$nulls":3},13,13,13,14,14,14,"138.34",0,"23.297",692770000,40,"0.538274","0.488219","-0.515337","-1.42767","sp|P53621|COPA_HUMAN","sp|P53621|COPA_HUMAN",1182,"P53621","COPA_HUMAN","Coatomer subunit alpha",null,"COPA"]
["16.3819","15.9658","16.9649","16.4149",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity","cytosol;intracellular membrane-bounded organelle;nucleus",{"$nulls":3},1,1,1,"2.4","2.4","2.4","51.571",0,"8.9685",22781000,4,"0.56353","0.470478","-0.516052","-1.4965","tr|M0R0P9|M0R0P9_HUMAN;sp|P31751|AKT2_HUMAN","tr|M0R0P9|M0R0P9_HUMAN;sp|P31751|AKT2_HUMAN",890,"M0R0P9","M0R0P9_HUMAN",null,null,"AKT2"]
["22.5607","22.0107","23.1701","22.4334",{"$nulls":3},"positive regulation of gene expression;transcription from RNA polymerase II promoter","DNA binding transcription factor activity;RNA binding;single-stranded DNA binding","nucleus",{"$nulls":3},14,14,9,"31.7","31.7","21.6","67.56",0,"82.036",1706100000,90,"0.422234","0.592724","-0.516068","-1.1227","sp|Q96AE4|FUBP1_HUMAN;tr|E9PEB5|E9PEB5_HUMAN","sp|Q96AE4|FUBP1_HUMAN;tr|E9PEB5|E9PEB5_HUMAN",2231,"Q96AE4","FUBP1_HUMAN","Far upstream element-binding protein 1","BP;USE-binding protein 1","FUBP1"]
["22.2937","22.3286","22.793","22.8618",{"$nulls":3},"apoptotic process;ceramide metabolic process;chromosome segregation;ciliary basal body-plasma membrane docking;female meiotic nuclear division;G2/M transition of mitotic cell cycle;inactivation of MAPK activity;meiotic sister chromatid cohesion, centromeric;meiotic spindle elongation;mitotic nuclear envelope reassembly;mitotic sister chromatid separation;negative regulation of cell growth;negative regulation of tyrosine phosphorylation of STAT protein;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;peptidyl-serine dephosphorylation;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;protein complex assembly;protein dephosphorylation;regulation of cell adhesion;regulation of cell differentiation;regulation of DNA replication;regulation of G2/M transition of mitotic cell cycle;regulation of growth;regulation of meiotic cell cycle process involved in oocyte maturation;regulation of transcription, DNA-templated;regulation of Wnt signaling pathway;response to organic substance;RNA splicing;second-messenger-mediated signaling","protein antigen binding;protein heterodimerization activity;protein phosphatase regulator activity;protein serine/threonine phosphatase activity","chromosome, centromeric region;cytosol;dendrite;extracellular exosome;lateral plasma membrane;membrane;microtubule cytoskeleton;mitochondrion;nucleus;protein phosphatase type 2A complex","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Chagas disease (American trypanosomiasis);Dopaminergic synapse;Hepatitis C;Hippo signaling pathway;Human papillomavirus infection;Long-term depression;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway;TGF-beta signaling pathway;Tight junction",null,null,14,14,12,"31.2","31.2","26.1","65.308",0,"194.56",1917600000,77,"2.25723","0.449818","-0.51623","-13.3909","sp|P30153|2AAA_HUMAN;tr|B3KQV6|B3KQV6_HUMAN;tr|C9J9C1|C9J9C1_HUMAN;tr|E9PH38|E9PH38_HUMAN;tr|M0QXG4|M0QXG4_HUMAN;tr|M0R0K6|M0R0K6_HUMAN;tr|E9PPI5|E9PPI5_HUMAN;tr|E9PNM7|E9PNM7_HUMAN;tr|E9PHZ6|E9PHZ6_HUMAN;tr|H0YDG7|H0YDG7_HUMAN","sp|P30153|2AAA_HUMAN;tr|B3KQV6|B3KQV6_HUMAN",866,"P30153","2AAA_HUMAN","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform",null,"PPP2R1A"]
["17.5821","17.3714","17.8413","18.1468",{"$nulls":9},2,2,2,"11.6","11.6","11.6","38.448","0.00039793","3.3318",26242000,9,"0.965699","0.294556","-0.51729","-2.78732","tr|A0A0A0MSZ9|A0A0A0MSZ9_HUMAN;sp|Q05048|CSTF1_HUMAN;tr|A3KFI9|A3KFI9_HUMAN","tr|A0A0A0MSZ9|A0A0A0MSZ9_HUMAN;sp|Q05048|CSTF1_HUMAN;tr|A3KFI9|A3KFI9_HUMAN",1450,"A0A0A0MSZ9","A0A0A0MSZ9_HUMAN",null,null,"CSTF1"]
["20.7788","21.0646","21.9987","20.8799",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"16.2","16.2","16.2","13.439",0,"41.288",183350000,8,"0.332888","0.702278","-0.517555","-0.896402","tr|Q5T093|Q5T093_HUMAN;tr|Q5T092|Q5T092_HUMAN;tr|A0A0A0MR06|A0A0A0MR06_HUMAN;tr|Q5T091|Q5T091_HUMAN;sp|O15258|RER1_HUMAN;tr|Q9P0H9|Q9P0H9_HUMAN","tr|Q5T093|Q5T093_HUMAN;tr|Q5T092|Q5T092_HUMAN;tr|A0A0A0MR06|A0A0A0MR06_HUMAN;tr|Q5T091|Q5T091_HUMAN;sp|O15258|RER1_HUMAN;tr|Q9P0H9|Q9P0H9_HUMAN",207,"Q5T093","Q5T093_HUMAN",null,null,"RER1"]
["16.5471","16.2497","18.1105","15.7225",{"$nulls":4},"GTP binding;GTPase activity",{"$nulls":4},1,1,1,"9.6","9.6","9.6","23.086",0,"22.459",12108000,3,"0.149526","0.875737","-0.518116","-0.430607","tr|H3BST5|H3BST5_HUMAN;sp|Q8IXI1|MIRO2_HUMAN","tr|H3BST5|H3BST5_HUMAN;sp|Q8IXI1|MIRO2_HUMAN",2021,"H3BST5","H3BST5_HUMAN",null,null,"RHOT2"]
["25.4435","25.2084","26.0102","25.6784",{"$nulls":3},"activation of protein kinase B activity;cell proliferation;cell redox homeostasis;cell-cell signaling;cellular response to oxidative stress;glycerol ether metabolic process;movement of cell or subcellular component;negative regulation of hydrogen peroxide-induced cell death;negative regulation of protein export from nucleus;negative regulation of transcription from RNA polymerase II promoter;nucleobase-containing small molecule interconversion;oxidation-reduction process;positive regulation of DNA binding;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein kinase B signaling;protein repair;regulation of protein import into nucleus, translocation;response to radiation;signal transduction;transcription, DNA-templated","oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;peptide disulfide oxidoreductase activity;protein disulfide oxidoreductase activity;protein-disulfide reductase activity;RNA binding;thioredoxin-disulfide reductase activity","cytoplasm;cytosol;extracellular exosome;mitochondrion;nucleus","Fluid shear stress and atherosclerosis;NOD-like receptor signaling pathway",null,null,2,2,2,21,21,21,"11.737",0,"12.293",3275900000,18,"0.901245","0.300006","-0.518349","-2.54943","sp|P10599|THIO_HUMAN","sp|P10599|THIO_HUMAN",608,"P10599","THIO_HUMAN","Thioredoxin","rx","TXN"]
["17.1802","17.4056","17.6732","17.9499",{"$nulls":3},"cellular response to drug;'de novo' pyrimidine nucleobase biosynthetic process;'de novo' UMP biosynthetic process;female pregnancy;lactation;pyrimidine nucleoside biosynthetic process;UMP biosynthetic process","identical protein binding;orotate phosphoribosyltransferase activity;orotidine-5'-phosphate decarboxylase activity","cytoplasm;cytosol;nucleus","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,2,2,2,"5.8","5.8","5.8","52.221","0.0011009","2.6402",62696000,6,"0.996689","0.295815","-0.51865","-2.90699","sp|P11172|UMPS_HUMAN;tr|F2Z3P2|F2Z3P2_HUMAN;tr|F2Z303|F2Z303_HUMAN;tr|F8WDG4|F8WDG4_HUMAN;tr|E9PFD2|E9PFD2_HUMAN","sp|P11172|UMPS_HUMAN;tr|F2Z3P2|F2Z3P2_HUMAN;tr|F2Z303|F2Z303_HUMAN;tr|F8WDG4|F8WDG4_HUMAN;tr|E9PFD2|E9PFD2_HUMAN",621,"P11172","UMPS_HUMAN","Uridine 5'-monophosphate synthase","MP synthase","UMPS"]
["18.4671","18.5849","20.2086","17.8811",{"$nulls":5},"nucleus",{"$nulls":3},11,11,11,"20.4","20.4","20.4","98.169",0,"35.709",254170000,32,"0.155107","0.871856","-0.518862","-0.445287","tr|E9PPJ0|E9PPJ0_HUMAN;sp|Q13435|SF3B2_HUMAN;tr|A0A087WZZ5|A0A087WZZ5_HUMAN;tr|E9PJ04|E9PJ04_HUMAN;tr|H0YCG1|H0YCG1_HUMAN;tr|E9PJT3|E9PJT3_HUMAN;tr|H0YEX5|H0YEX5_HUMAN;tr|E9PIL8|E9PIL8_HUMAN","tr|E9PPJ0|E9PPJ0_HUMAN;sp|Q13435|SF3B2_HUMAN;tr|A0A087WZZ5|A0A087WZZ5_HUMAN;tr|E9PJ04|E9PJ04_HUMAN;tr|H0YCG1|H0YCG1_HUMAN",1554,"E9PPJ0","E9PPJ0_HUMAN",null,null,"SF3B2"]
["21.7698","21.6282","22.1565","22.28",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"14.9","14.9","14.9","32.182",0,"99.107",679590000,19,"1.50549","0.320786","-0.519256","-5.52567","tr|I3L1P8|I3L1P8_HUMAN;sp|Q02978|M2OM_HUMAN","tr|I3L1P8|I3L1P8_HUMAN;sp|Q02978|M2OM_HUMAN",1436,"I3L1P8","I3L1P8_HUMAN",null,null,"SLC25A11"]
["19.916","19.4166","20.7595","19.6132",{"$nulls":3},"binding of sperm to zona pellucida;hematopoietic stem cell homeostasis;positive regulation of gene expression","RNA binding","cytoplasm;PcG protein complex",{"$nulls":3},11,11,11,"17.5","17.5","17.5","114.53",0,"54.149",228030000,43,"0.307117","0.719366","-0.519993","-0.831755","sp|Q14157|UBP2L_HUMAN;tr|F8W726|F8W726_HUMAN;tr|Q5VU78|Q5VU78_HUMAN;tr|Q5VU77|Q5VU77_HUMAN;tr|Q5VU81|Q5VU81_HUMAN;tr|Q5VU80|Q5VU80_HUMAN;tr|Q5VU79|Q5VU79_HUMAN;tr|H0Y5H6|H0Y5H6_HUMAN;tr|H7C2T8|H7C2T8_HUMAN","sp|Q14157|UBP2L_HUMAN;tr|F8W726|F8W726_HUMAN",1605,"Q14157","UBP2L_HUMAN","Ubiquitin-associated protein 2-like",null,"UBAP2L"]
["19.2515","18.3702","19.7064","18.9555",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity","cytosol",{"$nulls":3},6,6,6,"3.4","3.4","3.4","225.5",0,"112.61",289600000,25,"0.33367","0.701835","-0.520061","-0.898368","tr|F5GWT4|F5GWT4_HUMAN;sp|Q9H4A3|WNK1_HUMAN;tr|F6UYG0|F6UYG0_HUMAN","tr|F5GWT4|F5GWT4_HUMAN;sp|Q9H4A3|WNK1_HUMAN;tr|F6UYG0|F6UYG0_HUMAN",2595,"F5GWT4","F5GWT4_HUMAN",null,null,"WNK1"]
["19.9125","20.1053","20.8445","20.2144",{"$nulls":3},"ATP-dependent chromatin remodeling;chromatin remodeling;DNA recombination;DNA repair;histone H2A acetylation;histone H4 acetylation;neural retina development;positive regulation of protein targeting to mitochondrion;protein deubiquitination;regulation of autophagy of mitochondrion;regulation of growth;regulation of transcription from RNA polymerase II promoter;signal transduction;spinal cord development;transcription, DNA-templated","chromatin binding;transcription coactivator activity","Ino80 complex;npBAF complex;NuA4 histone acetyltransferase complex;nuclear chromatin;nucleoplasm;nucleus;plasma membrane;protein complex;SWI/SNF complex","Hepatocellular carcinoma;Thermogenesis",null,null,2,2,2,"5.6","5.6","5.6","47.46",0,"9.2702",268660000,12,"0.593642","0.443483","-0.520549","-1.57995","sp|O96019|ACL6A_HUMAN;tr|C9JQT2|C9JQT2_HUMAN;tr|H7C5S0|H7C5S0_HUMAN","sp|O96019|ACL6A_HUMAN;tr|C9JQT2|C9JQT2_HUMAN;tr|H7C5S0|H7C5S0_HUMAN",461,"O96019","ACL6A_HUMAN","Actin-like protein 6A",null,"ACTL6A"]
["23.9544","23.9257","24.6042","24.3182",{"$nulls":3},"translational elongation","translation elongation factor activity","cytoplasm;cytosol;eukaryotic translation elongation factor 1 complex",{"$nulls":3},7,7,7,"58.7","58.7","58.7","24.763",0,"171.63",2398300000,60,"1.16553","0.315789","-0.521165","-3.62728","sp|P24534|EF1B_HUMAN;tr|C9JZW3|C9JZW3_HUMAN;tr|F2Z2G2|F2Z2G2_HUMAN;tr|F8WF65|F8WF65_HUMAN","sp|P24534|EF1B_HUMAN",788,"P24534","EF1B_HUMAN","Elongation factor 1-beta","F-1-beta","EEF1B2"]
["15.4326","14.9007","16.2249","15.1508",{"$nulls":3},"cellular response to fatty acid;cellular response to glucose stimulus;glucose metabolic process;hypoxia-inducible factor-1alpha signaling pathway;peptidyl-serine phosphorylation;peroxisome proliferator activated receptor signaling pathway;regulation of acetyl-CoA biosynthetic process from pyruvate;regulation of glucose metabolic process;regulation of reactive oxygen species metabolic process","ATP binding;protein kinase activity;protein serine/threonine kinase activity;pyruvate dehydrogenase (acetyl-transferring) kinase activity","mitochondrial matrix;mitochondrion;nucleolus",{"$nulls":3},1,1,1,"3.9","3.9","3.9","46.938","0.0011132","2.7479",9136900,4,"0.322247","0.708215","-0.521197","-0.869695","sp|Q15120|PDK3_HUMAN","sp|Q15120|PDK3_HUMAN",1677,"Q15120","PDK3_HUMAN","[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial",null,"PDK3"]
["20.711","20.7468","21.7602","20.7402",{"$nulls":3},"bicellular tight junction assembly;lipopolysaccharide-mediated signaling pathway;negative regulation of apoptotic process;negative regulation of transcription from RNA polymerase II promoter;positive regulation of angiogenesis;positive regulation of autophagy;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of protein kinase B signaling","double-stranded RNA binding;NF-kappaB binding;RNA binding;RNA polymerase II transcription factor binding;transcription coactivator activity","apical plasma membrane;bicellular tight junction;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;fibrillar center;integral component of membrane;intercellular canaliculus;nuclear body;nuclear membrane;nucleus;perinuclear region of cytoplasm",{"$nulls":3},10,10,10,"21.8","21.8","21.8","63.836",0,"72.517",383180000,45,"0.382568","0.638265","-0.521356","-1.02164","sp|Q86UE4|LYRIC_HUMAN;tr|E5RJU9|E5RJU9_HUMAN;tr|H0YB56|H0YB56_HUMAN;tr|H0YBJ8|H0YBJ8_HUMAN","sp|Q86UE4|LYRIC_HUMAN;tr|E5RJU9|E5RJU9_HUMAN",1977,"Q86UE4","LYRIC_HUMAN","Protein LYRIC",null,"MTDH"]
["17.1561","17.3764","18.0223","17.5535",{"$nulls":3},"activation of blood coagulation via clotting cascade;bleb assembly;blood coagulation;bone mineralization involved in bone maturation;calcium activated galactosylceramide scrambling;calcium activated phosphatidylcholine scrambling;calcium activated phosphatidylserine scrambling;calcium ion transmembrane transport;cation transport;chloride transmembrane transport;chloride transport;dendritic cell chemotaxis;ion transmembrane transport;negative regulation of cell volume;neutrophil degranulation;phosphatidylserine exposure on blood platelet;phospholipid scrambling;pore complex assembly;positive regulation of apoptotic process;positive regulation of bone mineralization;positive regulation of endothelial cell apoptotic process;positive regulation of ion transmembrane transport;positive regulation of monocyte chemotaxis;positive regulation of phagocytosis, engulfment;positive regulation of potassium ion export;purinergic nucleotide receptor signaling pathway;sodium ion transmembrane transport","calcium activated cation channel activity;intracellular calcium activated chloride channel activity;phospholipid scramblase activity;protein homodimerization activity;voltage-gated chloride channel activity;voltage-gated ion channel activity","cell surface;chloride channel complex;cytosol;extracellular exosome;intracellular;membrane;plasma membrane;specific granule membrane;tertiary granule membrane",{"$nulls":3},2,2,2,"3.4","3.4","3.4","106.16",0,"4.4106",67227000,8,"0.740888","0.34181","-0.521644","-2.0141","sp|Q4KMQ2|ANO6_HUMAN","sp|Q4KMQ2|ANO6_HUMAN",1788,"Q4KMQ2","ANO6_HUMAN","Anoctamin-6",null,"ANO6"]
["12.4025","12.2475","12.2899","13.4043",{"$nulls":9},3,3,3,"1.4","1.4","1.4","358.62",0,"34.339",24080000,6,"0.345526","0.688558","-0.522159","-0.928161","tr|A0A087WV66|A0A087WV66_HUMAN;sp|P46013|KI67_HUMAN","tr|A0A087WV66|A0A087WV66_HUMAN;sp|P46013|KI67_HUMAN",1019,"A0A087WV66"]
["14.0777",1,"15.1239",1,{"$nulls":3},"androgen biosynthetic process;androgen receptor signaling pathway;angiogenesis;animal organ regeneration;brain development;cell morphogenesis;cellular response to epidermal growth factor stimulus;cellular response to hepatocyte growth factor stimulus;cellular response to steroid hormone stimulus;cellular response to thyroid hormone stimulus;embryonic heart tube development;embryonic hemopoiesis;embryonic hindlimb morphogenesis;embryonic placenta development;enucleate erythrocyte development;epithelial cell proliferation involved in mammary gland duct elongation;ERK1 and ERK2 cascade;erythrocyte development;fat cell differentiation;intracellular steroid hormone receptor signaling pathway;keratinocyte differentiation;lactation;lens development in camera-type eye;liver development;mammary gland branching involved in pregnancy;mammary gland branching involved in thelarche;megakaryocyte development;monocyte differentiation;mRNA transcription from RNA polymerase II promoter;negative regulation of apoptotic process;negative regulation of keratinocyte proliferation;negative regulation of neuron differentiation;negative regulation of transcription from RNA polymerase II promoter;peroxisome proliferator activated receptor signaling pathway;positive regulation of erythrocyte differentiation;positive regulation of G0 to G1 transition;positive regulation of gene expression;positive regulation of hepatocyte proliferation;positive regulation of interferon-gamma-mediated signaling pathway;positive regulation of intracellular estrogen receptor signaling pathway;positive regulation of keratinocyte differentiation;positive regulation of mammary gland epithelial cell proliferation;positive regulation of protein import into nucleus, translocation;positive regulation of receptor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of cell cycle;regulation of lipid metabolic process;regulation of RNA biosynthetic process;regulation of transcription from RNA polymerase I promoter;regulation of vitamin D receptor signaling pathway;retinal pigment epithelium development;thyroid hormone generation;thyroid hormone mediated signaling pathway;transcription initiation from RNA polymerase II promoter;ventricular trabecula myocardium morphogenesis","chromatin binding;chromatin DNA binding;core promoter binding;estrogen receptor binding;LBD domain binding;ligand-dependent nuclear receptor binding;ligand-dependent nuclear receptor transcription coactivator activity;mediator complex binding;nuclear hormone receptor binding;peroxisome proliferator activated receptor binding;receptor activity;retinoic acid receptor binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription cofactor activity;RNA polymerase II transcription factor activity, sequence-specific DNA binding;thyroid hormone receptor binding;thyroid hormone receptor coactivator activity;transcription coactivator activity;transcription cofactor activity;transcription factor binding;ubiquitin protein ligase activity;vitamin D receptor binding","chromatin;mediator complex;membrane;nucleolus;nucleoplasm;nucleus;protein-DNA complex;ubiquitin ligase complex","Endocrine resistance;Thyroid hormone signaling pathway",null,null,1,1,1,"0.9","0.9","0.9","168.48","0.0010616","2.3468",10829000,1,"0.0170065","0.977918","-0.523072","-0.0543489","sp|Q15648|MED1_HUMAN","sp|Q15648|MED1_HUMAN",1714,"Q15648","MED1_HUMAN","Mediator of RNA polymerase II transcription subunit 1",null,"MED1"]
["19.6024","19.715","20.3906","19.9748",{"$nulls":3},"protein targeting to ER;proteolysis;signal peptide processing","peptidase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;organelle membrane;signal peptidase complex","Protein export",null,null,1,1,1,"6.7","6.7","6.7","20.313",0,"4.5901",69151000,5,"0.868145","0.302418","-0.523973","-2.43266","sp|P61009|SPCS3_HUMAN","sp|P61009|SPCS3_HUMAN",1250,"P61009","SPCS3_HUMAN","Signal peptidase complex subunit 3",null,"SPCS3"]
["15.0391","15.0786","15.5102","15.6572",{"$nulls":9},1,1,1,"1.1","1.1","1.1","136.37",0,"3.7326",19794000,8,"1.69055","0.342409","-0.524863","-6.89532","tr|S4R400|S4R400_HUMAN;sp|Q5VW36|FOCAD_HUMAN","tr|S4R400|S4R400_HUMAN;sp|Q5VW36|FOCAD_HUMAN",1846,"S4R400","S4R400_HUMAN",null,null,"FOCAD"]
["19.2029","19.4503","20.2595","19.4441",{"$nulls":9},8,8,8,"21.8","21.8","21.8","66.734",0,"99.661",330450000,39,"0.464759","0.539074","-0.525166","-1.2326","tr|E5RIM3|E5RIM3_HUMAN;sp|Q9Y263|PLAP_HUMAN;tr|H0YBW4|H0YBW4_HUMAN;tr|H0YC16|H0YC16_HUMAN","tr|E5RIM3|E5RIM3_HUMAN;sp|Q9Y263|PLAP_HUMAN;tr|H0YBW4|H0YBW4_HUMAN",2940,"E5RIM3","E5RIM3_HUMAN",null,null,"PLAA"]
[1,"15.6029",1,"16.6547",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;interferon-gamma-mediated signaling pathway;regulation of immune response;type I interferon signaling pathway;viral process","peptide antigen binding","cell surface;early endosome membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},5,1,0,"20.2","3.8",0,"40.968","0.0011123","2.7389",12460000,1,"0.015346","0.979483","-0.525881","-0.0491288","sp|Q29963|1C06_HUMAN;sp|P30480|1B42_HUMAN;sp|P30460|1B08_HUMAN;sp|P01889|1B07_HUMAN;sp|Q07000|1C15_HUMAN;sp|P30501|1C02_HUMAN;sp|Q29865|1C18_HUMAN;sp|Q95365|1B38_HUMAN;sp|Q29836|1B67_HUMAN;sp|Q29718|1B82_HUMAN;sp|P30475|1B39_HUMAN;sp|P30462|1B14_HUMAN;sp|P18463|1B37_HUMAN;sp|P01893|HLAH_HUMAN;sp|P30505|1C08_HUMAN;tr|Q6DU44|Q6DU44_HUMAN;sp|P13747|HLAE_HUMAN","sp|Q29963|1C06_HUMAN;sp|P30480|1B42_HUMAN;sp|P30460|1B08_HUMAN;sp|P01889|1B07_HUMAN;sp|Q07000|1C15_HUMAN;sp|P30501|1C02_HUMAN;sp|Q29865|1C18_HUMAN;sp|Q95365|1B38_HUMAN;sp|Q29836|1B67_HUMAN;sp|Q29718|1B82_HUMAN;sp|P30475|1B39_HUMAN;sp|P30462|1B14_HUMAN;sp|P18463|1B37_HUMAN;sp|P01893|HLAH_HUMAN;sp|P30505|1C08_HUMAN",1766,"Q29963","1C06_HUMAN","HLA class I histocompatibility antigen, Cw-6 alpha chain",null,"HLA-C"]
["23.8472","23.4519","24.4132","23.9377",{"$nulls":3},"apoptotic cell clearance;cell redox homeostasis;cellular protein metabolic process;IRE1-mediated unfolded protein response;post-translational protein modification;protein folding;response to endoplasmic reticulum stress","peptide disulfide oxidoreductase activity;protein disulfide isomerase activity","cytosol;endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular space;melanosome;plasma membrane","Protein processing in endoplasmic reticulum",null,null,11,11,11,"36.4","36.4","36.4","48.121",0,"218.03",3003900000,85,"0.636285","0.408031","-0.525914","-1.70097","sp|Q15084|PDIA6_HUMAN","sp|Q15084|PDIA6_HUMAN",1675,"Q15084","PDIA6_HUMAN","Protein disulfide-isomerase A6",null,"PDIA6"]
["20.503","18.8482","20.6916","19.7118",{"$nulls":3},"cellular ketone metabolic process;in utero embryonic development;N-terminal peptidyl-glycine N-myristoylation;N-terminal protein myristoylation;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;regulation of rhodopsin mediated signaling pathway","glycylpeptide N-tetradecanoyltransferase activity;myristoyltransferase activity","cytoplasm;cytosol;extrinsic component of membrane;mitochondrion;plasma membrane",{"$nulls":3},6,6,6,"17.9","17.9","17.9","56.806",0,"16.359",288720000,34,"0.194361","0.828517","-0.526061","-0.547093","sp|P30419|NMT1_HUMAN;tr|K7EN82|K7EN82_HUMAN;tr|B7Z8J4|B7Z8J4_HUMAN;tr|Q5VUC6|Q5VUC6_HUMAN;sp|O60551|NMT2_HUMAN","sp|P30419|NMT1_HUMAN;tr|K7EN82|K7EN82_HUMAN",870,"P30419","NMT1_HUMAN","Glycylpeptide N-tetradecanoyltransferase 1",null,"NMT1"]
["20.7779","20.7714","21.5679","21.034",{"$nulls":3},"endosome localization;ferric iron import across plasma membrane;negative regulation of endocytic recycling;regulation of small GTPase mediated signal transduction;Rho protein signal transduction;small GTPase mediated signal transduction;transferrin transport","cadherin binding;GTPase activator activity;Rab GTPase binding;SH3 domain binding;SH3/SH2 adaptor activity","cytoplasm;cytosol;endosome membrane;extracellular exosome;perinuclear region of cytoplasm",{"$nulls":3},8,8,8,"29.4","29.4","29.4","50.435",0,"185.55",475130000,37,"0.727118","0.350588","-0.526311","-1.97142","sp|Q07960|RHG01_HUMAN;tr|H0YE29|H0YE29_HUMAN;tr|E9PNR6|E9PNR6_HUMAN","sp|Q07960|RHG01_HUMAN;tr|H0YE29|H0YE29_HUMAN;tr|E9PNR6|E9PNR6_HUMAN",1468,"Q07960","RHG01_HUMAN","Rho GTPase-activating protein 1",null,"ARHGAP1"]
["15.9761","15.8967","16.6821","16.2452",{"$nulls":3},"phosphatidylinositol dephosphorylation","hydrolase activity",{"$nulls":4},3,3,2,"3.8","3.8",3,"126.52",0,"6.8433",43158000,9,"0.85132","0.306063","-0.527245","-2.37463","tr|A0A0A0MTP6|A0A0A0MTP6_HUMAN;sp|O15357|SHIP2_HUMAN;tr|F5GY16|F5GY16_HUMAN","tr|A0A0A0MTP6|A0A0A0MTP6_HUMAN;sp|O15357|SHIP2_HUMAN",216,"A0A0A0MTP6","A0A0A0MTP6_HUMAN",null,null,"INPPL1"]
["15.8309","15.6519","16.4127","16.1246",{"$nulls":3},"attachment of GPI anchor to protein","GPI-anchor transamidase activity","endoplasmic reticulum membrane;GPI-anchor transamidase complex;membrane","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways",null,null,1,1,1,"3.1","3.1","3.1","61.655",0,"4.0782",16284000,3,"1.04703","0.304285","-0.527254","-3.10922","sp|Q96S52|PIGS_HUMAN","sp|Q96S52|PIGS_HUMAN",2352,"Q96S52","PIGS_HUMAN","GPI transamidase component PIG-S",null,"PIGS"]
["23.6663","23.4579","24.3422","23.8374",{"$nulls":3},"interleukin-12-mediated signaling pathway;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;cytosolic large ribosomal subunit;endoplasmic reticulum;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleus","Ribosome",null,null,11,11,11,"50.2","50.2","50.2","34.273",0,"96.018",1798000000,76,"0.714412","0.360426","-0.52768","-1.93246","sp|P05388|RLA0_HUMAN;tr|F8VWS0|F8VWS0_HUMAN;tr|F8VU65|F8VU65_HUMAN;sp|Q8NHW5|RLA0L_HUMAN;tr|F8VQY6|F8VQY6_HUMAN;tr|F8VPE8|F8VPE8_HUMAN;tr|F8VRK7|F8VRK7_HUMAN;tr|G3V210|G3V210_HUMAN;tr|F8VW21|F8VW21_HUMAN;tr|F8VZS0|F8VZS0_HUMAN;tr|F8VS58|F8VS58_HUMAN;tr|F8VWV4|F8VWV4_HUMAN;tr|F8W1K8|F8W1K8_HUMAN","sp|P05388|RLA0_HUMAN;tr|F8VWS0|F8VWS0_HUMAN;tr|F8VU65|F8VU65_HUMAN;sp|Q8NHW5|RLA0L_HUMAN;tr|F8VQY6|F8VQY6_HUMAN;tr|F8VPE8|F8VPE8_HUMAN;tr|F8VRK7|F8VRK7_HUMAN;tr|G3V210|G3V210_HUMAN;tr|F8VW21|F8VW21_HUMAN;tr|F8VZS0|F8VZS0_HUMAN;tr|F8VS58|F8VS58_HUMAN",520,"P05388","RLA0_HUMAN","60S acidic ribosomal protein P0",null,"RPLP0"]
["20.027","19.6873","20.6732","20.0966",{"$nulls":4},"GTP binding;GTPase activity",{"$nulls":4},5,5,5,"14.5","14.5","14.5","52.832",0,"17.192",327080000,27,"0.592653","0.445067","-0.527781","-1.57718","tr|H3BR35|H3BR35_HUMAN;sp|P15170|ERF3A_HUMAN;tr|H3BSV8|H3BSV8_HUMAN;sp|Q8IYD1|ERF3B_HUMAN","tr|H3BR35|H3BR35_HUMAN;sp|P15170|ERF3A_HUMAN",681,"H3BR35","H3BR35_HUMAN",null,null,"GSPT1"]
["21.6456","21.6546","22.6321","21.7239",{"$nulls":3},"spliceosomal snRNP assembly",null,"spliceosomal complex",{"$nulls":3},2,2,2,"31.2","31.2","31.2","7.1013",0,"4.5686",72065000,5,"0.437719","0.56791","-0.52789","-1.16251","tr|Q49AN9|Q49AN9_HUMAN;tr|F5H013|F5H013_HUMAN;sp|P62308|RUXG_HUMAN;sp|A8MWD9|RUXGL_HUMAN;tr|C9JVQ0|C9JVQ0_HUMAN","tr|Q49AN9|Q49AN9_HUMAN;tr|F5H013|F5H013_HUMAN;sp|P62308|RUXG_HUMAN;sp|A8MWD9|RUXGL_HUMAN;tr|C9JVQ0|C9JVQ0_HUMAN",113,"Q49AN9","Q49AN9_HUMAN"]
["19.3515","19.3905","20.0811","19.717",{"$nulls":3},"cyanate catabolic process;hydrogen sulfide biosynthetic process;kidney development;liver development;response to toxic substance;spinal cord development;transsulfuration","3-mercaptopyruvate sulfurtransferase activity;identical protein binding;thiosulfate sulfurtransferase activity","cell junction;cytosol;extracellular exosome;mitochondrion;neuron projection;synapse","Cysteine and methionine metabolism;Metabolic pathways;Sulfur metabolism;Sulfur relay system",null,null,3,3,3,"18.2","18.2","18.2","33.178",0,"15.415",120120000,11,"0.990819","0.299186","-0.528045","-2.88405","sp|P25325|THTM_HUMAN;tr|B1AH49|B1AH49_HUMAN","sp|P25325|THTM_HUMAN",795,"P25325","THTM_HUMAN","3-mercaptopyruvate sulfurtransferase","ST","MPST"]
["16.5049","16.1658","17.1682","16.5618",{"$nulls":4},"actin binding;protein phosphatase inhibitor activity",{"$nulls":4},1,1,1,"2.4","2.4","2.4","68.295",0,"8.6383",27770000,6,"0.573748","0.462428","-0.529636","-1.52464","tr|J3KP75|J3KP75_HUMAN;sp|O75167|PHAR2_HUMAN","tr|J3KP75|J3KP75_HUMAN;sp|O75167|PHAR2_HUMAN",327,"J3KP75","J3KP75_HUMAN","Phosphatase and actin regulator {ECO:0000256|RuleBase:RU301113}",null,"PHACTR2"]
["18.9121","17.5889","19.27","18.2914",{"$nulls":4},"4 iron, 4 sulfur cluster binding;FMN binding;NADH dehydrogenase (ubiquinone) activity","cytosol;mitochondrion",{"$nulls":3},3,3,3,"14.3","14.3","14.3","39.462",0,"4.2964",67089000,4,"0.23252","0.792296","-0.530158","-0.644251","tr|B4DE93|B4DE93_HUMAN;tr|G3V0I5|G3V0I5_HUMAN;sp|P49821|NDUV1_HUMAN;tr|E9PJL9|E9PJL9_HUMAN;tr|E9PLC6|E9PLC6_HUMAN;tr|E9PQP1|E9PQP1_HUMAN;tr|E9PMX3|E9PMX3_HUMAN;tr|H0YD04|H0YD04_HUMAN;tr|H0YE81|H0YE81_HUMAN;tr|E9PPR0|E9PPR0_HUMAN","tr|B4DE93|B4DE93_HUMAN;tr|G3V0I5|G3V0I5_HUMAN;sp|P49821|NDUV1_HUMAN;tr|E9PJL9|E9PJL9_HUMAN;tr|E9PLC6|E9PLC6_HUMAN;tr|E9PQP1|E9PQP1_HUMAN;tr|E9PMX3|E9PMX3_HUMAN",1099,"B4DE93","B4DE93_HUMAN",null,null,"NDUFV1"]
["19.2867","19.2241","20.3233","19.2488",{"$nulls":4},"NADH dehydrogenase (ubiquinone) activity","mitochondrion",{"$nulls":3},1,1,1,"26.1","26.1","26.1","8.0551","0.00039293","3.2215",18688000,4,"0.368487","0.659528","-0.530675","-0.986019","tr|F2Z3P9|F2Z3P9_HUMAN;tr|C9JXQ9|C9JXQ9_HUMAN;sp|O95168|NDUB4_HUMAN","tr|F2Z3P9|F2Z3P9_HUMAN;tr|C9JXQ9|C9JXQ9_HUMAN;sp|O95168|NDUB4_HUMAN",414,"F2Z3P9","F2Z3P9_HUMAN",null,null,"NDUFB4"]
["18.4823","19.0936","19.1057","19.5317",{"$nulls":9},1,1,1,"9.8","9.8","9.8","15.956",0,"5.5498",22809000,2,"0.537158","0.48998","-0.530774","-1.42466","tr|H0YNP9|H0YNP9_HUMAN;tr|H0YKT9|H0YKT9_HUMAN;sp|Q8N4P3|MESH1_HUMAN","tr|H0YNP9|H0YNP9_HUMAN;tr|H0YKT9|H0YKT9_HUMAN;sp|Q8N4P3|MESH1_HUMAN",2051,"H0YNP9","H0YNP9_HUMAN",null,null,"HDDC3"]
["25.1382","24.6678","25.3064","25.5623",{"$nulls":3},"cell proliferation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal large subunit assembly;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;RNA binding;rRNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;nucleolus;nucleus;TORC2 complex","Ribosome",null,null,4,4,4,"26.9","26.9","26.9","17.695",0,"124.21",2372300000,34,"0.731421","0.348179","-0.531337","-1.98471","sp|P62750|RL23A_HUMAN;tr|H7BY10|H7BY10_HUMAN;tr|K7EJV9|K7EJV9_HUMAN;tr|K7ERT8|K7ERT8_HUMAN;tr|A8MUS3|A8MUS3_HUMAN;tr|K7EMA7|K7EMA7_HUMAN","sp|P62750|RL23A_HUMAN;tr|H7BY10|H7BY10_HUMAN;tr|K7EJV9|K7EJV9_HUMAN;tr|K7ERT8|K7ERT8_HUMAN;tr|A8MUS3|A8MUS3_HUMAN;tr|K7EMA7|K7EMA7_HUMAN",1311,"P62750","RL23A_HUMAN","60S ribosomal protein L23a",null,"RPL23A"]
["20.0992","19.736","20.2586","20.6395",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;mitochondrial translation","NADH dehydrogenase (ubiquinone) activity;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrial ribosome;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,2,2,2,"23.9","23.9","23.9","12.551",0,"3.9986",57145000,3,"0.742585","0.342456","-0.531483","-2.01939","sp|O95182|NDUA7_HUMAN","sp|O95182|NDUA7_HUMAN",415,"O95182","NDUA7_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7",null,"NDUFA7"]
["23.9748","24.1233","24.752","24.4092",{"$nulls":3},"cell proliferation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;rRNA processing;sister chromatid cohesion;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","DNA binding;RNA binding;structural constituent of ribosome;zinc ion binding","cytosol;cytosolic small ribosomal subunit;nucleoplasm;nucleus;ribosome","Ribosome",null,null,4,4,2,"39.3","39.3","14.3","9.461",0,"47.733",885410000,23,"0.981061","0.294976","-0.531568","-2.8462","sp|P42677|RS27_HUMAN;tr|Q5T4L4|Q5T4L4_HUMAN","sp|P42677|RS27_HUMAN;tr|Q5T4L4|Q5T4L4_HUMAN",996,"P42677","RS27_HUMAN","40S ribosomal protein S27",null,"RPS27"]
["21.9518","21.9195","22.6707","22.265",{"$nulls":9},3,3,3,"26.4","26.4","26.4","14.369",0,"7.8208",335260000,5,"0.919397","0.29377","-0.532196","-2.61498","tr|C9JXB8|C9JXB8_HUMAN;tr|C9JNW5|C9JNW5_HUMAN;sp|P83731|RL24_HUMAN","tr|C9JXB8|C9JXB8_HUMAN;tr|C9JNW5|C9JNW5_HUMAN;sp|P83731|RL24_HUMAN",1389,"C9JXB8","C9JXB8_HUMAN",null,null,"RPL24"]
["19.2028","18.8891","19.9604","19.1959",{"$nulls":5},"cytosol;fibrillar center;nucleus",{"$nulls":3},12,12,12,"10.2","10.2","10.2","152.3",0,"80.067",455620000,44,"0.485937","0.523257","-0.5322","-1.28807","tr|E7ETY2|E7ETY2_HUMAN;tr|J3KQ96|J3KQ96_HUMAN;sp|Q13428|TCOF_HUMAN;tr|H0YA99|H0YA99_HUMAN","tr|E7ETY2|E7ETY2_HUMAN;tr|J3KQ96|J3KQ96_HUMAN;sp|Q13428|TCOF_HUMAN",3085,"E7ETY2","E7ETY2_HUMAN",null,null,"TCOF1"]
["14.8452","15.4726","15.4925","15.8899",{"$nulls":3},"activation of MAPK activity;adaptive immune response;angiogenesis involved in wound healing;autophagy;axon guidance;cell chemotaxis;cell migration;cellular calcium ion homeostasis;chemotaxis;embryonic cleavage;endothelial cell proliferation;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;G-protein coupled receptor signaling pathway;homophilic cell adhesion via plasma membrane adhesion molecules;inflammatory response;innate immune response;interleukin-7-mediated signaling pathway;leukocyte migration;phosphatidylinositol 3-kinase signaling;phosphatidylinositol biosynthetic process;phosphatidylinositol-mediated signaling;phosphorylation;platelet activation;platelet aggregation;positive regulation of autophagy;positive regulation of gene expression;positive regulation of neutrophil apoptotic process;positive regulation of protein kinase B signaling;regulation of cell-matrix adhesion;regulation of clathrin-dependent endocytosis;signal transduction;T cell receptor signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;vascular endothelial growth factor receptor signaling pathway","1-phosphatidylinositol-3-kinase activity;1-phosphatidylinositol-4-phosphate 3-kinase activity;ATP binding;insulin receptor substrate binding;kinase activity;phosphatidylinositol 3-kinase activity;phosphatidylinositol-4,5-bisphosphate 3-kinase activity","cytoplasm;cytosol;midbody;nucleolus;nucleus;phosphatidylinositol 3-kinase complex;plasma membrane","Acute myeloid leukemia;AGE-RAGE signaling pathway in diabetic complications;Aldosterone-regulated sodium reabsorption;Amoebiasis;AMPK signaling pathway;Apoptosis;Autophagy - animal;Axon guidance;B cell receptor signaling pathway;Bacterial invasion of epithelial cells;Breast cancer;cAMP signaling pathway;Carbohydrate digestion and absorption;Cellular senescence;Central carbon metabolism in cancer;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;C-type lectin receptor signaling pathway;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;Epstein-Barr virus infection;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Inflammatory mediator regulation of TRP channels;Influenza A;Inositol phosphate metabolism;Insulin resistance;Insulin signaling pathway;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Longevity regulating pathway;Longevity regulating pathway - multiple species;Measles;Melanoma;Metabolic pathways;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Non-small cell lung cancer;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Platelet activation;Platinum drug resistance;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Signaling pathways regulating pluripotency of stem cells;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid hormone signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Type II diabetes mellitus;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,1,1,1,"1.4","1.4","1.4","122.76",0,"5.8508",24782000,6,"0.540467","0.486493","-0.532281","-1.43361","sp|P42338|PK3CB_HUMAN","sp|P42338|PK3CB_HUMAN",993,"P42338","PK3CB_HUMAN","Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform","I3Kbeta;I3K-beta;I3-kinase subunit beta;tdIns-3-kinase subunit beta","PIK3CB"]
["16.5393","16.2381","17.2716","16.5708",{"$nulls":3},"transcription, DNA-templated","DNA binding;DNA-directed 5'-3' RNA polymerase activity;ribonucleoside binding","nucleoplasm",{"$nulls":3},3,3,3,"4.9","4.9","4.9","133.06",0,"6.5825",68635000,12,"0.526594","0.499323","-0.532499","-1.39618","tr|C9J2Y9|C9J2Y9_HUMAN;sp|P30876|RPB2_HUMAN;tr|C9J4M6|C9J4M6_HUMAN","tr|C9J2Y9|C9J2Y9_HUMAN;sp|P30876|RPB2_HUMAN;tr|C9J4M6|C9J4M6_HUMAN",880,"C9J2Y9","C9J2Y9_HUMAN","DNA-directed RNA polymerase subunit beta {ECO:0000256|RuleBase:RU363031}",null,"POLR2B"]
["18.5623","18.545","20.1075","18.0658",{"$nulls":3},"cardiovascular system development;fatty acid metabolic process;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;mitochondrion morphogenesis;multicellular organism aging;multicellular organism growth;muscle contraction;reproductive system development","electron transfer activity;NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex I","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,1,1,1,"17.7","17.7","17.7","13.711","0.0094617","1.6924",33495000,5,"0.184625","0.834786","-0.532969","-0.522053","sp|O75380|NDUS6_HUMAN;tr|D6RBT3|D6RBT3_HUMAN","sp|O75380|NDUS6_HUMAN;tr|D6RBT3|D6RBT3_HUMAN",337,"O75380","NDUS6_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial",null,"NDUFS6"]
["23.6421","23.7121","24.2828","24.1377",{"$nulls":3},"regulation of microtubule polymerization or depolymerization",{"$nulls":5},2,1,1,"11.3",6,6,"19.574",0,"10.832",1637400000,9,"1.65618","0.334356","-0.533212","-6.61925","tr|E5RGX5|E5RGX5_HUMAN;sp|Q93045|STMN2_HUMAN","tr|E5RGX5|E5RGX5_HUMAN;sp|Q93045|STMN2_HUMAN",2215,"E5RGX5","E5RGX5_HUMAN","Stathmin {ECO:0000256|RuleBase:RU004388}",null,"STMN2"]
["20.1473","19.9304","20.6882","20.456",{"$nulls":3},"ER to Golgi vesicle-mediated transport;IRE1-mediated unfolded protein response;protein transport;regulation of endocytosis;retrograde vesicle-mediated transport, Golgi to ER","GTPase activator activity;metal ion binding","cytosol;Golgi apparatus;postsynaptic density","Endocytosis",null,null,7,7,7,"25.1","25.1","25.1","44.667",0,"63.836",230130000,24,"1.10539","0.308987","-0.533274","-3.35662","sp|Q8N6T3|ARFG1_HUMAN;tr|E5RHT6|E5RHT6_HUMAN;tr|E5RHC5|E5RHC5_HUMAN;tr|F8W1U7|F8W1U7_HUMAN;tr|F8VWH9|F8VWH9_HUMAN;tr|H0YIQ0|H0YIQ0_HUMAN;tr|E5RHH7|E5RHH7_HUMAN","sp|Q8N6T3|ARFG1_HUMAN;tr|E5RHT6|E5RHT6_HUMAN;tr|E5RHC5|E5RHC5_HUMAN;tr|F8W1U7|F8W1U7_HUMAN;tr|F8VWH9|F8VWH9_HUMAN",2062,"Q8N6T3","ARFG1_HUMAN","ADP-ribosylation factor GTPase-activating protein 1","RF GAP 1","ARFGAP1"]
["22.3333","22.0461","23.041","22.4064",{"$nulls":3},"'de novo' IMP biosynthetic process","phosphoribosylaminoimidazolesuccinocarboxamide synthase activity",{"$nulls":4},9,9,9,24,24,24,"45.651",0,"142.55",1033000000,42,"0.576806","0.461041","-0.534019","-1.5331","tr|E9PBS1|E9PBS1_HUMAN;sp|P22234|PUR6_HUMAN;tr|D6RF62|D6RF62_HUMAN","tr|E9PBS1|E9PBS1_HUMAN;sp|P22234|PUR6_HUMAN;tr|D6RF62|D6RF62_HUMAN",763,"E9PBS1","E9PBS1_HUMAN",null,null,"PAICS"]
["18.6402","18.6082","19.4074","18.911",{"$nulls":4},"RNA binding","mRNA cleavage factor complex;nuclear speck;nucleoplasm",{"$nulls":3},3,3,3,10,10,10,"52.269",0,"46.71",60429000,9,"0.784107","0.332861","-0.534963","-2.15119","tr|F8WJN3|F8WJN3_HUMAN;sp|Q16630|CPSF6_HUMAN","tr|F8WJN3|F8WJN3_HUMAN;sp|Q16630|CPSF6_HUMAN",1746,"F8WJN3","F8WJN3_HUMAN",null,null,"CPSF6"]
["15.1572","15.5688","15.6479","16.1483",{"$nulls":3},"cell division;meiotic cell cycle;negative regulation of DNA endoreduplication;regulation of mitotic spindle assembly;sister chromatid cohesion",null,"chromatin;chromosome;chromosome, centromeric region;cohesin complex;cytosol;membrane;mitotic spindle pole;nuclear matrix;nucleoplasm;nucleus","Cell cycle",null,null,2,2,2,"3.2","3.2","3.2","141.32","0.00075901","2.8937",31120000,2,"0.619079","0.423557","-0.535059","-1.65172","sp|Q8N3U4|STAG2_HUMAN;tr|B1AMT0|B1AMT0_HUMAN;tr|B1AMT1|B1AMT1_HUMAN;tr|B1AMT2|B1AMT2_HUMAN;tr|B1AMT3|B1AMT3_HUMAN;tr|C9JJQ0|C9JJQ0_HUMAN;tr|B1AMT4|B1AMT4_HUMAN;sp|Q8WVM7|STAG1_HUMAN","sp|Q8N3U4|STAG2_HUMAN;tr|B1AMT0|B1AMT0_HUMAN;tr|B1AMT1|B1AMT1_HUMAN;tr|B1AMT2|B1AMT2_HUMAN;tr|B1AMT3|B1AMT3_HUMAN;tr|C9JJQ0|C9JJQ0_HUMAN;tr|B1AMT4|B1AMT4_HUMAN;sp|Q8WVM7|STAG1_HUMAN",2047,"Q8N3U4","STAG2_HUMAN","Cohesin subunit SA-2",null,"STAG2"]
["12.9173","12.892","13.7071","13.1742",{"$nulls":3},"angiogenesis","ATPase activity;metal ion binding;ubiquitin-protein transferase activity","cytosol;nucleolus",{"$nulls":3},2,2,2,"0.5","0.5","0.5","591.4","0.0014114","2.3247",23230000,1,"0.739289","0.341267","-0.536017","-2.00912","tr|A0A0A0MTR7|A0A0A0MTR7_HUMAN;sp|Q63HN8|RN213_HUMAN;tr|A0A0A0MTC1|A0A0A0MTC1_HUMAN","tr|A0A0A0MTR7|A0A0A0MTR7_HUMAN;sp|Q63HN8|RN213_HUMAN;tr|A0A0A0MTC1|A0A0A0MTC1_HUMAN",1853,"A0A0A0MTR7","A0A0A0MTR7_HUMAN",null,null,"RNF213"]
["20.0868","20.0626","20.754","20.4693",{"$nulls":3},"negative regulation of angiogenesis;negative regulation of cytosolic calcium ion concentration;signal transduction;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;transition between slow and fast fiber","DNA binding;DNA binding transcription factor activity;mitogen-activated protein kinase binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding","cell projection;cytoplasm;membrane;neuronal cell body;nucleoplasm;nucleus","Basal transcription factors;cGMP-PKG signaling pathway",null,null,15,15,15,"24.8","24.8","24.8","112.42",0,"128.16",663030000,77,"1.1934","0.325908","-0.536947","-3.7585","sp|P78347|GTF2I_HUMAN;tr|C9J6M0|C9J6M0_HUMAN","sp|P78347|GTF2I_HUMAN",1367,"P78347","GTF2I_HUMAN","General transcription factor II-I","FII-I;TFII-I","GTF2I"]
["24.7159","24.7427","25.5387","24.994",{"$nulls":3},"cellular response to ionizing radiation;mRNA transcription;positive regulation of I-kappaB kinase/NF-kappaB signaling;regulation of cell death;regulation of transcription, DNA-templated;transcription, DNA-templated;translational elongation","activating transcription factor binding;cadherin binding;DNA binding;heat shock protein binding;signal transducer activity;translation elongation factor activity;translation factor activity, RNA binding","cytoplasm;cytosol;eukaryotic translation elongation factor 1 complex;fibrillar center;nucleus",{"$nulls":3},11,11,6,"54.1","54.1","32.7","31.121",0,"202.6",5215000000,108,"0.726511","0.351619","-0.53703","-1.96955","sp|P29692|EF1D_HUMAN;tr|E9PK01|E9PK01_HUMAN;tr|E9PRY8|E9PRY8_HUMAN;tr|A0A087X1X7|A0A087X1X7_HUMAN;tr|E9PPR1|E9PPR1_HUMAN;tr|E9PL12|E9PL12_HUMAN;tr|E9PQ49|E9PQ49_HUMAN;tr|E9PI39|E9PI39_HUMAN;tr|E9PQZ1|E9PQZ1_HUMAN;tr|E9PMW7|E9PMW7_HUMAN;tr|E9PIZ1|E9PIZ1_HUMAN;tr|H0YCK7|H0YCK7_HUMAN;tr|H0YE58|H0YE58_HUMAN;tr|E9PK06|E9PK06_HUMAN;tr|H0YE72|H0YE72_HUMAN;tr|E9PK72|E9PK72_HUMAN;tr|E9PQC9|E9PQC9_HUMAN;tr|E9PKK3|E9PKK3_HUMAN;tr|E9PNW6|E9PNW6_HUMAN;tr|E9PJD0|E9PJD0_HUMAN","sp|P29692|EF1D_HUMAN;tr|E9PK01|E9PK01_HUMAN;tr|E9PRY8|E9PRY8_HUMAN;tr|A0A087X1X7|A0A087X1X7_HUMAN;tr|E9PPR1|E9PPR1_HUMAN;tr|E9PL12|E9PL12_HUMAN;tr|E9PQ49|E9PQ49_HUMAN;tr|E9PI39|E9PI39_HUMAN;tr|E9PQZ1|E9PQZ1_HUMAN;tr|E9PMW7|E9PMW7_HUMAN",850,"P29692","EF1D_HUMAN","Elongation factor 1-delta","F-1-delta","EEF1D"]
["17.5118","17.5966","17.9724","18.2116",{"$nulls":3},"regulation of transcription, DNA-templated",{"$nulls":5},2,1,1,12,"6.7","6.7","25.981",0,"3.6911",22821000,2,"1.28894","0.331757","-0.537807","-4.2384","tr|C9JSU1|C9JSU1_HUMAN;sp|Q9Y608|LRRF2_HUMAN","tr|C9JSU1|C9JSU1_HUMAN;sp|Q9Y608|LRRF2_HUMAN",3036,"C9JSU1","C9JSU1_HUMAN",null,null,"LRRFIP2"]
["19.355","18.8985","19.9254","19.4042",{"$nulls":3},"phenylalanyl-tRNA aminoacylation;protein heterotetramerization;translation;tRNA aminoacylation for protein translation","ATP binding;magnesium ion binding;phenylalanine-tRNA ligase activity;RNA binding","cytoplasm;cytosol;membrane;phenylalanine-tRNA ligase complex","Aminoacyl-tRNA biosynthesis",null,null,4,4,4,"6.5","6.5","6.5","66.115",0,"7.9917",198870000,14,"0.584117","0.451402","-0.538109","-1.55338","sp|Q9NSD9|SYFB_HUMAN","sp|Q9NSD9|SYFB_HUMAN",2692,"Q9NSD9","SYFB_HUMAN","Phenylalanine--tRNA ligase beta subunit",null,"FARSB"]
["16.9839","16.554","17.8402","16.7753",{"$nulls":3},"cell separation after cytokinesis;endosomal transport;endosome to lysosome transport;ESCRT III complex disassembly;lysosome organization;mitotic metaphase plate congression;multivesicular body assembly;multivesicular body sorting pathway;nucleus organization;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;regulation of receptor recycling;viral budding;viral life cycle","cadherin binding","cytosol;endosome membrane;extracellular exosome;nucleus","Endocytosis;Necroptosis",null,null,1,1,1,"9.6","9.6","9.6","24.57",0,"22.048",10519000,3,"0.349582","0.685695","-0.538811","-0.938366","sp|Q9NZZ3|CHMP5_HUMAN","sp|Q9NZZ3|CHMP5_HUMAN",2766,"Q9NZZ3","CHMP5_HUMAN","Charged multivesicular body protein 5",null,"CHMP5"]
["15.2418","14.966","15.6666","15.6201",{"$nulls":3},"regulation of Rho protein signal transduction","Rho guanyl-nucleotide exchange factor activity",{"$nulls":4},1,1,1,"1.4","1.4","1.4","91.296","0.0044414","2.0458",18195000,1,"1.21411","0.320573","-0.539503","-3.8585","tr|M0QZS0|M0QZS0_HUMAN;tr|A0A087WZG4|A0A087WZG4_HUMAN;tr|M0R150|M0R150_HUMAN;sp|Q6ZSZ5|ARHGI_HUMAN","tr|M0QZS0|M0QZS0_HUMAN;tr|A0A087WZG4|A0A087WZG4_HUMAN;tr|M0R150|M0R150_HUMAN;sp|Q6ZSZ5|ARHGI_HUMAN",1918,"M0QZS0","M0QZS0_HUMAN",null,null,"ARHGEF18"]
["22.181","22.0789","22.7652","22.5737",{"$nulls":3},"barbed-end actin filament capping;negative regulation of actin filament polymerization;positive regulation of cardiac muscle hypertrophy;regulation of actin phosphorylation;sequestering of actin monomers","actin binding;actin monomer binding;ATP binding;cadherin binding;phosphatidylinositol-4,5-bisphosphate binding;protein complex binding","actin cytoskeleton;cell-cell junction;cytosol;filopodium;focal adhesion;myofibril;perinuclear region of cytoplasm;ruffle membrane",{"$nulls":3},8,8,8,"33.1","33.1","33.1","40.282",0,"195.22",1393900000,49,"1.41847","0.335477","-0.539504","-4.97192","sp|Q12792|TWF1_HUMAN;tr|F8VS81|F8VS81_HUMAN;tr|F8VRG3|F8VRG3_HUMAN;tr|F8W1Q9|F8W1Q9_HUMAN","sp|Q12792|TWF1_HUMAN;tr|F8VS81|F8VS81_HUMAN",1493,"Q12792","TWF1_HUMAN","Twinfilin-1",null,"TWF1"]
["20.3131","20.3583","21.4367","20.3144",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of insulin secretion;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of insulin secretion;positive regulation of transcription, DNA-templated;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome regulatory particle assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent protein catabolic process;Wnt signaling pathway, planar cell polarity pathway","bHLH transcription factor binding;transcription coactivator activity","cytoplasm;cytosol;nucleoplasm;nucleus;proteasome regulatory particle",{"$nulls":3},3,3,3,13,13,13,"24.682",0,"34.729",208130000,15,"0.358678","0.671016","-0.539854","-0.961273","sp|O00233|PSMD9_HUMAN;tr|F5H5V4|F5H5V4_HUMAN;tr|F5GX23|F5GX23_HUMAN;tr|J3KN29|J3KN29_HUMAN;tr|F5H7X1|F5H7X1_HUMAN;tr|F5H169|F5H169_HUMAN","sp|O00233|PSMD9_HUMAN;tr|F5H5V4|F5H5V4_HUMAN;tr|F5GX23|F5GX23_HUMAN;tr|J3KN29|J3KN29_HUMAN",129,"O00233","PSMD9_HUMAN","26S proteasome non-ATPase regulatory subunit 9",null,"PSMD9"]
["15.3031","15.0504","16.3075","15.1261",{"$nulls":3},"defense response to Gram-positive bacterium;defense response to virus;dendritic cell proliferation;I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;negative regulation of gene expression;negative regulation of type I interferon production;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-beta biosynthetic process;positive regulation of interferon-beta production;positive regulation of macroautophagy;positive regulation of peptidyl-serine phosphorylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;positive regulation of xenophagy;protein phosphorylation;regulation of neuron death;regulation of type I interferon production;response to virus;TRIF-dependent toll-like receptor signaling pathway;type I interferon production;viral process","ATP binding;identical protein binding;nucleic acid binding;phosphoprotein binding;protein kinase activity;protein serine/threonine kinase activity","cytoplasm;cytosol;endosome membrane","Cytosolic DNA-sensing pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;IL-17 signaling pathway;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;Mitophagy - animal;NOD-like receptor signaling pathway;Ras signaling pathway;RIG-I-like receptor signaling pathway;Toll-like receptor signaling pathway;Yersinia infection",null,null,2,2,2,"4.5","4.5","4.5","83.641",0,"3.747",21560000,5,"0.331943","0.702892","-0.540048","-0.894029","sp|Q9UHD2|TBK1_HUMAN","sp|Q9UHD2|TBK1_HUMAN",2830,"Q9UHD2","TBK1_HUMAN","Serine/threonine-protein kinase TBK1",null,"TBK1"]
["20.2552","19.6647","20.7128","20.2891",{"$nulls":3},"active induction of host immune response by virus;apoptotic process;protein targeting to mitochondrion;regulation of insulin secretion;regulation of mitochondrial membrane permeability","adenine transmembrane transporter activity;ATP:ADP antiporter activity","extracellular matrix;integral component of membrane;mitochondrial inner membrane;mitochondrial inner membrane presequence translocase complex;mitochondrion;nucleus","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Necroptosis;Parkinson disease",null,null,7,2,1,"24.5","9.1","4.4","32.866",0,"3.9998",247290000,8,"0.560644","0.471257","-0.540972","-1.48858","sp|P12236|ADT3_HUMAN","sp|P12236|ADT3_HUMAN",642,"P12236","ADT3_HUMAN","ADP/ATP translocase 3",null,"SLC25A6"]
["22.3826","21.9342","23.0312","22.3682",{"$nulls":3},"negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of protein neddylation;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of ubiquitin protein ligase activity;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of gene expression;positive regulation of protein binding;protein localization to nucleus;protein stabilization;protein targeting;regulation of signal transduction by p53 class mediator;ribosomal large subunit assembly;ribosomal large subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","5S rRNA binding;RNA binding;structural constituent of ribosome;ubiquitin ligase inhibitor activity;ubiquitin protein ligase binding","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;membrane;nucleolus;nucleoplasm;protein complex","Ribosome",null,null,3,3,3,"16.9","16.9","16.9","20.252",0,"74.468",571190000,15,"0.510245","0.512913","-0.541274","-1.35243","sp|P62913|RL11_HUMAN;tr|Q5VVC9|Q5VVC9_HUMAN;tr|Q5VVC8|Q5VVC8_HUMAN","sp|P62913|RL11_HUMAN;tr|Q5VVC9|Q5VVC9_HUMAN;tr|Q5VVC8|Q5VVC8_HUMAN",1332,"P62913","RL11_HUMAN","60S ribosomal protein L11",null,"RPL11"]
["20.6154","20.1679","21.2595","20.6068",{"$nulls":3},"CRD-mediated mRNA stabilization;mRNA transport;negative regulation of translation;neuronal stem cell population maintenance;pallium cell proliferation in forebrain;regulation of cytokine biosynthetic process;regulation of mRNA stability;regulation of mRNA stability involved in response to stress","mRNA 3'-UTR binding;mRNA 5'-UTR binding;mRNA binding;RNA binding;translation regulator activity","axon;CRD-mediated mRNA stability complex;cytoplasm;cytoplasmic stress granule;cytosol;dendritic spine;filopodium;growth cone;intracellular ribonucleoprotein complex;lamellipodium;nucleoplasm;perinuclear region of cytoplasm","MicroRNAs in cancer",null,null,11,11,10,"25.3","25.3","23.1","63.48",0,"28.948",520240000,47,"0.516216","0.509723","-0.541493","-1.36837","sp|Q9NZI8|IF2B1_HUMAN","sp|Q9NZI8|IF2B1_HUMAN",2757,"Q9NZI8","IF2B1_HUMAN","Insulin-like growth factor 2 mRNA-binding protein 1","GF2 mRNA-binding protein 1;MP1;MP-1","IGF2BP1"]
["18.9063","18.4212","19.5336","18.878",{"$nulls":5},"cytosol",{"$nulls":3},10,10,10,"12.3","12.3","12.3","101.2",0,"39.779",277350000,30,"0.501546","0.513689","-0.542053","-1.32931","tr|A0A0B4J1W3|A0A0B4J1W3_HUMAN;sp|Q9BXJ9|NAA15_HUMAN;sp|Q6N069|NAA16_HUMAN","tr|A0A0B4J1W3|A0A0B4J1W3_HUMAN;sp|Q9BXJ9|NAA15_HUMAN",2496,"A0A0B4J1W3","A0A0B4J1W3_HUMAN",null,null,"NAA15"]
["20.6617","20.4114","21.6099","20.5493",{"$nulls":3},"ATP hydrolysis coupled proton transport;ATP metabolic process;insulin receptor signaling pathway;ion transmembrane transport;phagosome acidification;proton transport;regulation of macroautophagy;transferrin transport","ATP binding;hydrogen ion transmembrane transporter activity;proton-transporting ATPase activity, rotational mechanism","cytosol;endomembrane system;extracellular exosome;integral component of membrane;intracellular membrane-bounded organelle;lysosomal membrane;melanosome;microvillus;myelin sheath;plasma membrane;proton-transporting V-type ATPase, V1 domain;ruffle","Collecting duct acid secretion;Epithelial cell signaling in Helicobacter pylori infection;Human papillomavirus infection;Metabolic pathways;mTOR signaling pathway;Oxidative phosphorylation;Phagosome;Rheumatoid arthritis;Synaptic vesicle cycle;Vibrio cholerae infection",null,null,10,10,10,"28.2","28.2","28.2","56.5",0,"78.443",492700000,36,"0.372717","0.65141","-0.543036","-0.996706","sp|P21281|VATB2_HUMAN;tr|H0YC04|H0YC04_HUMAN;tr|H0YAT8|H0YAT8_HUMAN;tr|E5RGH6|E5RGH6_HUMAN;tr|C9JL73|C9JL73_HUMAN;sp|P15313|VATB1_HUMAN;tr|C9JZ02|C9JZ02_HUMAN;tr|C9J5E3|C9J5E3_HUMAN;tr|C9JNS9|C9JNS9_HUMAN","sp|P21281|VATB2_HUMAN;tr|H0YC04|H0YC04_HUMAN",751,"P21281","VATB2_HUMAN","V-type proton ATPase subunit B, brain isoform","-ATPase subunit B 2","ATP6V1B2"]
["15.8251","15.447","16.7008","15.6576",{"$nulls":3},"angiogenesis;meiotic attachment of telomere to nuclear envelope;negative regulation of activin receptor signaling pathway;negative regulation of BMP signaling pathway;negative regulation of transforming growth factor beta receptor signaling pathway;nuclear envelope organization;regulation of intracellular signal transduction","chromatin DNA binding","integral component of membrane;integral component of nuclear inner membrane;membrane;nuclear inner membrane;nuclear membrane",{"$nulls":3},3,3,3,"6.7","6.7","6.7","99.996",0,"7.0848",29202000,6,"0.365663","0.66409","-0.543092","-0.978891","sp|Q9Y2U8|MAN1_HUMAN","sp|Q9Y2U8|MAN1_HUMAN",2959,"Q9Y2U8","MAN1_HUMAN","Inner nuclear membrane protein Man1",null,"LEMD3"]
["17.9335","17.684","18.6944","18.0111",{"$nulls":3},"cell cycle;central nervous system development;intracellular signal transduction;negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;peptidyl-serine phosphorylation;positive regulation of cell differentiation;positive regulation of cell growth;positive regulation of transcription from RNA polymerase II promoter;regulation of DNA-templated transcription in response to stress;regulation of translation in response to stress;response to lipopolysaccharide;signal transduction;skeletal system development;toll-like receptor signaling pathway","ATP binding;cysteine-type endopeptidase inhibitor activity involved in apoptotic process;kinase activity;magnesium ion binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity","cytoplasm;cytosol;nucleoplasm;nucleus","Insulin resistance;Long-term potentiation;MAPK signaling pathway;mTOR signaling pathway;Neurotrophin signaling pathway;Oocyte meiosis;Progesterone-mediated oocyte maturation;Thermogenesis;Yersinia infection",null,null,6,6,4,"10.7","10.7","8.1","83.735",0,"12.594",131310000,23,"0.563255","0.470137","-0.544023","-1.49575","sp|P51812|KS6A3_HUMAN;tr|B1AXG2|B1AXG2_HUMAN;tr|E9PAN7|E9PAN7_HUMAN;tr|B1AXG1|B1AXG1_HUMAN;sp|Q9UK32|KS6A6_HUMAN;tr|D6RHW7|D6RHW7_HUMAN;tr|E9PMM7|E9PMM7_HUMAN;tr|D6R910|D6R910_HUMAN;tr|D6RA62|D6RA62_HUMAN;tr|D6RE03|D6RE03_HUMAN;tr|B7Z3B5|B7Z3B5_HUMAN;sp|Q15349|KS6A2_HUMAN;tr|F2Z2J1|F2Z2J1_HUMAN","sp|P51812|KS6A3_HUMAN",1147,"P51812","KS6A3_HUMAN","Ribosomal protein S6 kinase alpha-3","6K-alpha-3","RPS6KA3"]
["14.358","13.2246","15.1969","13.4742",{"$nulls":3},"defense response to virus;germinal center formation;granuloma formation;natural killer cell degranulation;neutrophil degranulation;phagocytosis;positive regulation of exocytosis;positive regulation of regulated secretory pathway;positive regulation of substrate adhesion-dependent cell spreading;regulation of mast cell degranulation","Rab GTPase binding","azurophil granule lumen;cytosol;endoplasmic reticulum;exocytic vesicle;extracellular region;late endosome;lysosome;membrane;recycling endosome;Weibel-Palade body",{"$nulls":3},2,2,2,"3.3","3.3","3.3","123.28","0.00040306","3.4197",16828000,5,"0.186884","0.833632","-0.54425","-0.527874","sp|Q70J99|UN13D_HUMAN;tr|K7EN29|K7EN29_HUMAN","sp|Q70J99|UN13D_HUMAN;tr|K7EN29|K7EN29_HUMAN",1923,"Q70J99","UN13D_HUMAN","Protein unc-13 homolog D",null,"UNC13D"]
["19.7921","19.6262","20.4178","20.0927",{"$nulls":3},"canonical glycolysis;carbohydrate phosphorylation;cellular glucose homeostasis;establishment of protein localization to mitochondrion;glycolytic process;maintenance of protein location in mitochondrion;positive regulation of cytokine secretion involved in immune response;positive regulation of interleukin-1 beta secretion","ATP binding;fructokinase activity;glucokinase activity;glucose binding;hexokinase activity;mannokinase activity;peptidoglycan binding","cytosol;membrane raft;mitochondrial outer membrane;mitochondrion;sperm principal piece","Amino sugar and nucleotide sugar metabolism;Carbohydrate digestion and absorption;Carbon metabolism;Central carbon metabolism in cancer;Fructose and mannose metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Insulin signaling pathway;Metabolic pathways;Neomycin, kanamycin and gentamicin biosynthesis;Starch and sucrose metabolism;Type II diabetes mellitus",null,null,10,10,7,"13.8","13.8","9.9","102.48",0,"27.16",386370000,23,"1.01832","0.296491","-0.546134","-2.99265","sp|P19367|HXK1_HUMAN;tr|B1AR62|B1AR62_HUMAN;tr|B1AR61|B1AR61_HUMAN;sp|Q2TB90|HKDC1_HUMAN","sp|P19367|HXK1_HUMAN",729,"P19367","HXK1_HUMAN","Hexokinase-1",null,"HK1"]
["20.551",1,"21.6439",1,{"$nulls":3},"DNA damage response, detection of DNA damage;global genome nucleotide-excision repair;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein monoubiquitination;protein neddylation;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF complex assembly;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;transcription-coupled nucleotide-excision repair;viral process;Wnt signaling pathway","cullin family protein binding;ligase activity;NEDD8 transferase activity;protein complex binding;transcription factor binding;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity;ubiquitin-ubiquitin ligase activity;zinc ion binding","Cul2-RING ubiquitin ligase complex;Cul3-RING ubiquitin ligase complex;Cul4A-RING E3 ubiquitin ligase complex;Cul4B-RING E3 ubiquitin ligase complex;Cul5-RING ubiquitin ligase complex;Cul7-RING ubiquitin ligase complex;cullin-RING ubiquitin ligase complex;cytosol;nuclear SCF ubiquitin ligase complex;nucleoplasm;SCF ubiquitin ligase complex;VCB complex","Cell cycle;Circadian rhythm;HIF-1 signaling pathway;Human immunodeficiency virus 1 infection;Nucleotide excision repair;Oocyte meiosis;Pathways in cancer;Protein processing in endoplasmic reticulum;Renal cell carcinoma;TGF-beta signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway",null,null,2,2,2,"17.6","17.6","17.6","12.274",0,"19.754",59814000,7,"0.0119622","0.982205","-0.546413","-0.0384357","sp|P62877|RBX1_HUMAN","sp|P62877|RBX1_HUMAN",1326,"P62877","RBX1_HUMAN","E3 ubiquitin-protein ligase RBX1",null,"RBX1"]
["19.5669","19.5264","20.25","19.9379",{"$nulls":4},"microtubule motor activity","kinesin complex",{"$nulls":3},10,10,8,"18.9","18.9","15.9","68.774",0,"56.515",414020000,43,"1.13273","0.313343","-0.547284","-3.47761","tr|G3V3H3|G3V3H3_HUMAN;tr|G3V5R9|G3V5R9_HUMAN;tr|G5E9S8|G5E9S8_HUMAN;tr|G3V2E7|G3V2E7_HUMAN;sp|Q07866|KLC1_HUMAN;tr|F8W6L3|F8W6L3_HUMAN;tr|E7EVH7|E7EVH7_HUMAN;tr|H0YJU9|H0YJU9_HUMAN;tr|H0YJL0|H0YJL0_HUMAN;tr|H0YJT3|H0YJT3_HUMAN;tr|H0YG16|H0YG16_HUMAN;tr|G3V2P7|G3V2P7_HUMAN;tr|H0YGB8|H0YGB8_HUMAN","tr|G3V3H3|G3V3H3_HUMAN;tr|G3V5R9|G3V5R9_HUMAN;tr|G5E9S8|G5E9S8_HUMAN;tr|G3V2E7|G3V2E7_HUMAN;sp|Q07866|KLC1_HUMAN;tr|F8W6L3|F8W6L3_HUMAN;tr|E7EVH7|E7EVH7_HUMAN",3098,"G3V3H3","G3V3H3_HUMAN",null,null,"KLC1"]
["25.733","25.6733","26.2476","26.2535",{"$nulls":3},"erythrocyte differentiation;maturation of SSU-rRNA;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);negative regulation of transcription from RNA polymerase II promoter;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA 5'-UTR binding;RNA binding;small ribosomal subunit rRNA binding;structural constituent of ribosome;translation regulator activity","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;mitochondrion;nucleolus;nucleoplasm","Ribosome",null,null,5,5,5,"32.5","32.5","32.5","16.273",0,"84.319",2830700000,38,"2.52462","0.530909","-0.547343","-18.2531","sp|P62263|RS14_HUMAN;tr|H0YB22|H0YB22_HUMAN;tr|E5RH77|E5RH77_HUMAN","sp|P62263|RS14_HUMAN",1297,"P62263","RS14_HUMAN","40S ribosomal protein S14",null,"RPS14"]
["16.4056","16.1127","16.9065","16.7073",{"$nulls":9},1,1,1,"2.9","2.9","2.9","52.787",0,"5.4606",24039000,7,"1.04291","0.300607","-0.547729","-3.09229","tr|H0YBM4|H0YBM4_HUMAN;tr|H0YBF7|H0YBF7_HUMAN;tr|A0A0A0MRE5|A0A0A0MRE5_HUMAN;sp|Q9ULH1|ASAP1_HUMAN","tr|H0YBM4|H0YBM4_HUMAN;tr|H0YBF7|H0YBF7_HUMAN;tr|A0A0A0MRE5|A0A0A0MRE5_HUMAN;sp|Q9ULH1|ASAP1_HUMAN",2892,"H0YBM4","H0YBM4_HUMAN",null,null,"ASAP1"]
["19.3893","18.9712","19.9579","19.5014",{"$nulls":3},"autophagosome assembly;autophagy of mitochondrion;autophagy of nucleus;cellular protein modification process;macroautophagy;mitochondrial fragmentation involved in apoptotic process;negative regulation of phagocytosis;protein targeting to membrane;protein ubiquitination;regulation of cilium assembly","Atg12 transferase activity;Atg8 ligase activity;enzyme binding;ligase activity;ubiquitin-like protein transferase activity","cytoplasmic ubiquitin ligase complex;cytosol","Autophagy - animal;Autophagy - other;Kaposi sarcoma-associated herpesvirus infection",null,null,3,3,3,"13.1","13.1","13.1","35.864",0,"6.0557",78230000,13,"0.6618","0.38966","-0.549373","-1.7751","sp|Q9NT62|ATG3_HUMAN;tr|F8WDI0|F8WDI0_HUMAN","sp|Q9NT62|ATG3_HUMAN",2695,"Q9NT62","ATG3_HUMAN","Ubiquitin-like-conjugating enzyme ATG3",null,"ATG3"]
["15.0972","14.8165","15.8449","15.1681",{"$nulls":3},"cell division;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;protein localization to centrosome;regulation of G2/M transition of mitotic cell cycle",null,"apical part of cell;centriole;centrosome;ciliary basal body;cytosol;pericentriolar material;spindle pole",{"$nulls":3},1,1,1,"3.2","3.2","3.2","71.965",0,"3.5078",12284000,5,"0.564857","0.469119","-0.549613","-1.50015","sp|Q8NHV4|NEDD1_HUMAN","sp|Q8NHV4|NEDD1_HUMAN",2103,"Q8NHV4","NEDD1_HUMAN","Protein NEDD1",null,"NEDD1"]
["20.5219","20.3226","21.5354","20.4114",{"$nulls":3},"chaperone cofactor-dependent protein refolding;chaperone mediated protein folding requiring cofactor;negative regulation of inclusion body assembly;negative regulation of transcription from RNA polymerase II promoter in response to stress;positive regulation of ATPase activity;regulation of cellular response to heat;response to unfolded protein","ATPase activator activity;ATPase binding;cadherin binding;chaperone binding;Hsp70 protein binding;RNA polymerase II transcription corepressor activity;unfolded protein binding","cytoplasm;cytosol;extracellular exosome;nucleolus;nucleoplasm;nucleus","Influenza A;Protein processing in endoplasmic reticulum",null,null,5,5,5,"18.2","18.2","18.2","38.044",0,"26.838",315470000,19,"0.360428","0.668746","-0.551198","-0.965686","sp|P25685|DNJB1_HUMAN;tr|M0R080|M0R080_HUMAN","sp|P25685|DNJB1_HUMAN",798,"P25685","DNJB1_HUMAN","DnaJ homolog subfamily B member 1",null,"DNAJB1"]
["24.1856","24.1382","24.8654","24.5614",{"$nulls":3},"carbohydrate metabolic process","catalytic activity","cytosol;integral component of membrane;nucleus;plasma membrane",{"$nulls":3},18,18,12,"39.6","39.6","26.5","64.872",0,"177.48",6971800000,86,"1.15626","0.313522","-0.551486","-3.58446","tr|F5GZS6|F5GZS6_HUMAN;sp|P08195|4F2_HUMAN;tr|J3KPF3|J3KPF3_HUMAN;tr|H0YFS2|H0YFS2_HUMAN;tr|F5GZI0|F5GZI0_HUMAN;tr|H0YFX4|H0YFX4_HUMAN","tr|F5GZS6|F5GZS6_HUMAN;sp|P08195|4F2_HUMAN;tr|J3KPF3|J3KPF3_HUMAN",557,"F5GZS6","F5GZS6_HUMAN",null,null,"SLC3A2"]
["19.5073","19.4763","20.4691","19.6199",{"$nulls":3},"mitochondrial translational termination;ribosome disassembly;translation","ribosomal large subunit binding","mitochondrial matrix;mitochondrion",{"$nulls":3},3,3,3,"15.3","15.3","15.3","29.277",0,"11.373",107440000,13,"0.490815","0.519835","-0.552747","-1.30092","sp|Q96E11|RRFM_HUMAN","sp|Q96E11|RRFM_HUMAN",2259,"Q96E11","RRFM_HUMAN","Ribosome-recycling factor, mitochondrial","RF","MRRF"]
["21.792","22.064","22.771","22.1907",{"$nulls":3},"estrogen biosynthetic process;extracellular matrix organization;fatty acid biosynthetic process;long-chain fatty-acyl-CoA biosynthetic process;positive regulation of cell-substrate adhesion","3-oxo-arachidoyl-CoA reductase activity;3-oxo-behenoyl-CoA reductase activity;3-oxo-cerotoyl-CoA reductase activity;3-oxo-lignoceroyl-CoA reductase activity;collagen binding;estradiol 17-beta-dehydrogenase activity;fibronectin binding;heparin binding;long-chain-3-hydroxyacyl-CoA dehydrogenase activity","endoplasmic reticulum membrane;integral component of membrane;proteinaceous extracellular matrix","Biosynthesis of unsaturated fatty acids;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways;Steroid hormone biosynthesis",null,null,6,6,6,"17.9","17.9","17.9","34.324",0,"23.566",824060000,37,"0.644684","0.401553","-0.552843","-1.72522","sp|Q53GQ0|DHB12_HUMAN;tr|E9PI21|E9PI21_HUMAN","sp|Q53GQ0|DHB12_HUMAN",1794,"Q53GQ0","DHB12_HUMAN","Very-long-chain 3-oxoacyl-CoA reductase {ECO:0000305}",null,"HSD17B12"]
["20.6034","20.124","20.9617","20.8723",{"$nulls":4},"phosphatidylinositol binding",{"$nulls":4},4,4,4,25,25,25,"19.825",0,"39.644",185720000,10,"0.820086","0.321594","-0.553286","-2.26918","tr|A0A087X0R6|A0A087X0R6_HUMAN;sp|Q9UMY4|SNX12_HUMAN","tr|A0A087X0R6|A0A087X0R6_HUMAN;sp|Q9UMY4|SNX12_HUMAN",2903,"A0A087X0R6","A0A087X0R6_HUMAN",null,null,"SNX12"]
["18.9081","18.5573","19.4331","19.1393",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome regulatory particle assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway",null,"cytosol;nucleoplasm;proteasome accessory complex;proteasome complex",{"$nulls":3},5,5,5,"14.9","14.9","14.9","56.195",0,"70.893",155560000,20,"0.864315","0.301256","-0.553509","-2.41937","sp|Q16401|PSMD5_HUMAN;tr|F2Z3J2|F2Z3J2_HUMAN","sp|Q16401|PSMD5_HUMAN",1735,"Q16401","PSMD5_HUMAN","26S proteasome non-ATPase regulatory subunit 5",null,"PSMD5"]
["17.0896","17.0807","17.7919","17.486",{"$nulls":9},2,2,2,"3.8","3.8","3.8","87.183",0,"12.469",84464000,11,"1.16375","0.312655","-0.553796","-3.61904","tr|A0A0A0MS45|A0A0A0MS45_HUMAN;sp|Q9H9E3|COG4_HUMAN;tr|J3KNI1|J3KNI1_HUMAN;tr|J3QLW1|J3QLW1_HUMAN;tr|E9PRT5|E9PRT5_HUMAN;tr|H3BSD2|H3BSD2_HUMAN;tr|H3BMV9|H3BMV9_HUMAN","tr|A0A0A0MS45|A0A0A0MS45_HUMAN;sp|Q9H9E3|COG4_HUMAN;tr|J3KNI1|J3KNI1_HUMAN;tr|J3QLW1|J3QLW1_HUMAN;tr|E9PRT5|E9PRT5_HUMAN;tr|H3BSD2|H3BSD2_HUMAN;tr|H3BMV9|H3BMV9_HUMAN",2623,"A0A0A0MS45","A0A0A0MS45_HUMAN",null,null,"COG4"]
["24.1702","23.9653","24.9801","24.2632",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},4,4,4,"36.1","36.1","36.1","12.701",0,"8.458",1441300000,26,"0.559638","0.471306","-0.553905","-1.48583","tr|H7C2W9|H7C2W9_HUMAN;tr|C9JU56|C9JU56_HUMAN;tr|B7Z4E3|B7Z4E3_HUMAN;sp|P62899|RL31_HUMAN;tr|B7Z4C8|B7Z4C8_HUMAN;tr|B8ZZK4|B8ZZK4_HUMAN","tr|H7C2W9|H7C2W9_HUMAN;tr|C9JU56|C9JU56_HUMAN;tr|B7Z4E3|B7Z4E3_HUMAN;sp|P62899|RL31_HUMAN;tr|B7Z4C8|B7Z4C8_HUMAN;tr|B8ZZK4|B8ZZK4_HUMAN",1329,"H7C2W9","H7C2W9_HUMAN",null,null,"RPL31"]
["22.5745","22.711","23.1759","23.2184",{"$nulls":3},"activation of MAPK activity;cellular protein modification process;DNA double-strand break processing;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;Fc-epsilon receptor signaling pathway;global genome nucleotide-excision repair;histone ubiquitination;JNK cascade;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of DNA repair;positive regulation of histone modification;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of ubiquitin-protein transferase activity;postreplication repair;protein K63-linked ubiquitination;protein ubiquitination;proteolysis;regulation of DNA repair;regulation of histone ubiquitination;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway","ATP binding;RNA binding;ubiquitin binding;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;fibrillar center;nucleoplasm;nucleus;protein complex;UBC13-MMS2 complex;UBC13-UEV1A complex;ubiquitin ligase complex","Ubiquitin mediated proteolysis",null,null,4,4,4,"36.8","36.8","36.8","17.138",0,"67.51",778180000,11,"1.79043","0.370486","-0.554396","-7.76046","sp|P61088|UBE2N_HUMAN;tr|F8VZ29|F8VZ29_HUMAN;tr|F8VSD4|F8VSD4_HUMAN;tr|F8VV71|F8VV71_HUMAN;sp|Q5JXB2|UE2NL_HUMAN;tr|F8VQQ8|F8VQQ8_HUMAN","sp|P61088|UBE2N_HUMAN;tr|F8VZ29|F8VZ29_HUMAN;tr|F8VSD4|F8VSD4_HUMAN;tr|F8VV71|F8VV71_HUMAN;sp|Q5JXB2|UE2NL_HUMAN",1257,"P61088","UBE2N_HUMAN","Ubiquitin-conjugating enzyme E2 N",null,"UBE2N"]
["22.4332","22.1168","23.0768","22.5824",{"$nulls":3},"gene silencing by RNA;osteoblast differentiation;regulation of transcription, DNA-templated;RNA catabolic process;transcription, DNA-templated;viral process","cadherin binding;nuclease activity;RNA binding;transcription cofactor activity","cytoplasm;cytosol;dense body;extracellular exosome;melanosome;membrane;mitochondrion;nucleus;RISC complex","Viral carcinogenesis",null,null,29,29,29,"41.3","41.3","41.3",102,0,"323.31",3493500000,125,"0.700369","0.366778","-0.554599","-1.88984","sp|Q7KZF4|SND1_HUMAN;tr|H7C597|H7C597_HUMAN","sp|Q7KZF4|SND1_HUMAN",1928,"Q7KZF4","SND1_HUMAN","Staphylococcal nuclease domain-containing protein 1",null,"SND1"]
["17.7479","17.7367","18.8374","17.7565",{"$nulls":3},"cell proliferation;endocytosis;lipid tube assembly;membrane organization;muscle cell differentiation;nucleus localization;nucleus organization;positive regulation of apoptotic process;positive regulation of astrocyte differentiation;regulation of cell cycle arrest;regulation of endocytosis;regulation of neuron differentiation;viral process","actin filament binding;identical protein binding;RNA polymerase binding;tau protein binding","actin cytoskeleton;axon;axon initial segment;cytoplasm;cytosol;I band;lipid tube;membrane;node of Ranvier;nuclear envelope;T-tubule;Z disc","Endocytosis;Fc gamma R-mediated phagocytosis",null,null,3,3,3,"6.7","6.7","6.7","64.699",0,"5.2927",87476000,2,"0.384366","0.635975","-0.554662","-1.02619","sp|O00499|BIN1_HUMAN","sp|O00499|BIN1_HUMAN",147,"O00499","BIN1_HUMAN","Myc box-dependent-interacting protein 1",null,"BIN1"]
["18.2185",1,"19.3281",1,{"$nulls":4},"RNA binding",{"$nulls":4},1,1,1,"14.9","14.9","14.9","9.9402","0.0011013","2.6448",21160000,2,"0.0137603","0.980557","-0.554847","-0.0441274","tr|E9PQK4|E9PQK4_HUMAN;tr|E9PSH0|E9PSH0_HUMAN;tr|E9PKU1|E9PKU1_HUMAN;sp|Q92879|CELF1_HUMAN;tr|G5EA30|G5EA30_HUMAN","tr|E9PQK4|E9PQK4_HUMAN;tr|E9PSH0|E9PSH0_HUMAN;tr|E9PKU1|E9PKU1_HUMAN;sp|Q92879|CELF1_HUMAN;tr|G5EA30|G5EA30_HUMAN",2198,"E9PQK4","E9PQK4_HUMAN",null,null,"CELF1"]
["22.4229","22.0962","23.2507","22.3787",{"$nulls":3},"maintenance of translational fidelity;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;stress granule assembly;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;membrane;nucleoplasm;ribosome","Ribosome",null,null,2,2,2,"15.4","15.4","15.4","15.807",0,"4.7699",453080000,14,"0.449241","0.553476","-0.555102","-1.19228","sp|P62266|RS23_HUMAN;tr|D6RD47|D6RD47_HUMAN","sp|P62266|RS23_HUMAN;tr|D6RD47|D6RD47_HUMAN",1298,"P62266","RS23_HUMAN","40S ribosomal protein S23",null,"RPS23"]
["15.3352","14.56","16.051","14.9559",{"$nulls":3},"miRNA mediated inhibition of translation","nucleic acid binding",{"$nulls":4},3,3,3,"4.4","4.4","4.4","148.57",0,"8.007",26846000,11,"0.305842","0.723773","-0.555851","-0.82856","tr|H0Y720|H0Y720_HUMAN;sp|Q9UPQ9|TNR6B_HUMAN","tr|H0Y720|H0Y720_HUMAN;sp|Q9UPQ9|TNR6B_HUMAN",2922,"H0Y720","H0Y720_HUMAN",null,null,"TNRC6B"]
["23.4381","22.5287","23.2809","23.7979",{"$nulls":3},"chemotaxis;cytokine-mediated signaling pathway;ion transport","chemokine binding;ion transmembrane transporter activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;membrane;plasma membrane",{"$nulls":3},1,1,1,"8.6","8.6","8.6","16.691",0,"28.476",449210000,3,"0.398883","0.622495","-0.556014","-1.06306","sp|Q04941|PLP2_HUMAN","sp|Q04941|PLP2_HUMAN",1449,"Q04941","PLP2_HUMAN","Proteolipid protein 2",null,"PLP2"]
["18.6836","18.4729","18.8407","19.4278",{"$nulls":3},"cell growth;endoplasmic reticulum organization;IRE1-mediated unfolded protein response;posttranslational protein targeting to endoplasmic reticulum membrane;pronephric nephron development;protein targeting to ER;response to interferon-gamma;SRP-dependent cotranslational protein targeting to membrane","ribosome binding","cytosol;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane;rough endoplasmic reticulum","Phagosome;Protein export;Protein processing in endoplasmic reticulum;Vibrio cholerae infection",null,null,2,2,2,4,4,4,"52.264","0.00039139","3.1852",87742000,4,"0.664428","0.388991","-0.556026","-1.78282","sp|P61619|S61A1_HUMAN;tr|B4DR61|B4DR61_HUMAN","sp|P61619|S61A1_HUMAN;tr|B4DR61|B4DR61_HUMAN",1277,"P61619","S61A1_HUMAN","Protein transport protein Sec61 subunit alpha isoform 1","ec61 alpha-1","SEC61A1"]
["20.2452","20.0626","21.0537","20.3667",{"$nulls":3},"DNA repair;DNA replication;DNA replication-independent nucleosome organization;nucleosome disassembly;positive regulation of DNA-templated transcription, elongation;positive regulation of transcription elongation from RNA polymerase II promoter;regulation of signal transduction by p53 class mediator;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","histone binding;nucleosome binding;RNA binding","chromosome;FACT complex;nucleoplasm;nucleus",{"$nulls":3},12,12,12,"14.7","14.7","14.7","119.91",0,"36.453",774160000,40,"0.588314","0.450566","-0.55629","-1.56507","sp|Q9Y5B9|SP16H_HUMAN","sp|Q9Y5B9|SP16H_HUMAN",3016,"Q9Y5B9","SP16H_HUMAN","FACT complex subunit SPT16",null,"SUPT16H"]
["20.9608","20.9032","21.7901","21.1876",{"$nulls":3},"protein import into mitochondrial matrix",null,"integral component of membrane;mitochondrial outer membrane translocase complex",{"$nulls":3},1,1,1,"12.7","12.7","12.7","6.3495","0.0075958","1.7772",67926000,3,"0.683814","0.376787","-0.556837","-1.84019","tr|A0A087WZY2|A0A087WZY2_HUMAN;sp|Q9P0U1|TOM7_HUMAN;tr|A6NIV2|A6NIV2_HUMAN","tr|A0A087WZY2|A0A087WZY2_HUMAN;sp|Q9P0U1|TOM7_HUMAN;tr|A6NIV2|A6NIV2_HUMAN",2775,"A0A087WZY2","A0A087WZY2_HUMAN",null,null,"TOMM7"]
["21.8229","22.04","22.4102","22.5669",{"$nulls":3},"mitotic cell cycle;positive regulation by host of symbiont catalytic activity;regulation of protein stability",null,"cytosol;kinetochore;nucleus;protein complex;ubiquitin ligase complex","NOD-like receptor signaling pathway",null,null,13,13,13,"48.5","48.5","48.5","41.024",0,"101.46",1051900000,82,"1.2744","0.32928","-0.55712","-4.16221","sp|Q9Y2Z0|SGT1_HUMAN","sp|Q9Y2Z0|SGT1_HUMAN",2964,"Q9Y2Z0","SGT1_HUMAN","Protein SGT1 homolog {ECO:0000250|UniProtKB:Q08446}",null,"SUGT1"]
["18.4351","18.5736","19.3222","18.8029",{"$nulls":3},"establishment of cell polarity;microtubule cytoskeleton organization","ATP binding;protein serine/threonine kinase activity",{"$nulls":4},4,4,4,10,10,10,"78.452",0,"48.641",184890000,25,"0.760917","0.338717","-0.558187","-2.07702","tr|E7ETY4|E7ETY4_HUMAN;tr|E9PC69|E9PC69_HUMAN;sp|Q7KZI7|MARK2_HUMAN;tr|F5H4J8|F5H4J8_HUMAN;tr|F5H6N2|F5H6N2_HUMAN;tr|F5H4F6|F5H4F6_HUMAN","tr|E7ETY4|E7ETY4_HUMAN;tr|E9PC69|E9PC69_HUMAN;sp|Q7KZI7|MARK2_HUMAN",3086,"E7ETY4","E7ETY4_HUMAN","Non-specific serine/threonine protein kinase {ECO:0000256|SAAS:SAAS00804148}",null,"MARK2"]
["21.5025","21.22","22.0096","21.8315",{"$nulls":3},"negative regulation of cell proliferation","cadherin binding;RNA binding;zinc ion binding","cell junction;cytosol;focal adhesion;nucleus;plasma membrane;protein complex",{"$nulls":3},7,7,7,"20.4","20.4","20.4","47.996",0,"51.42",774870000,31,"1.10372","0.309149","-0.559274","-3.34934","sp|Q9UGI8|TES_HUMAN;tr|F8W7T0|F8W7T0_HUMAN;tr|H7BYK1|H7BYK1_HUMAN","sp|Q9UGI8|TES_HUMAN",2822,"Q9UGI8","TES_HUMAN","Testin",null,"TES"]
["26.1201","26.1062","26.7919","26.5533",{"$nulls":3},"ATP metabolic process;cellular response to starvation;chaperone mediated protein folding requiring cofactor;chaperone-mediated autophagy;chaperone-mediated autophagy translocation complex disassembly;chaperone-mediated protein transport involved in chaperone-mediated autophagy;clathrin coat disassembly;late endosomal microautophagy;membrane organization;mRNA splicing, via spliceosome;negative regulation of supramolecular fiber organization;negative regulation of transcription, DNA-templated;neurotransmitter secretion;neutrophil degranulation;positive regulation by host of viral genome replication;positive regulation of mRNA splicing, via spliceosome;protein folding;protein methylation;protein refolding;protein targeting to lysosome involved in chaperone-mediated autophagy;regulation of cell cycle;regulation of cellular response to heat;regulation of mRNA stability;regulation of protein complex assembly;regulation of protein complex stability;regulation of protein import;regulation of protein stability;response to unfolded protein;transcription, DNA-templated;viral process","ATP binding;ATPase activity;ATPase activity, coupled;C3HC4-type RING finger domain binding;cadherin binding;enzyme binding;G-protein coupled receptor binding;heat shock protein binding;MHC class II protein complex binding;phosphatidylserine binding;RNA binding;ubiquitin protein ligase binding;unfolded protein binding","blood microparticle;clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;cytosol;extracellular exosome;extracellular matrix;extracellular region;extracellular space;ficolin-1-rich granule lumen;focal adhesion;intracellular;intracellular ribonucleoprotein complex;late endosome;lumenal side of lysosomal membrane;lysosomal lumen;lysosomal membrane;melanosome;membrane;myelin sheath;nucleolus;nucleoplasm;nucleus;plasma membrane;presynapse;Prp19 complex;secretory granule lumen;spliceosomal complex","Antigen processing and presentation;Endocytosis;Estrogen signaling pathway;Legionellosis;Longevity regulating pathway - multiple species;MAPK signaling pathway;Measles;Protein processing in endoplasmic reticulum;Spliceosome;Toxoplasmosis",null,null,26,25,17,"48.6","48.6","35.6","70.897",0,"323.31",31419000000,361,"1.36921","0.334464","-0.559445","-4.68088","sp|P11142|HSP7C_HUMAN;tr|E9PKE3|E9PKE3_HUMAN;tr|E9PN89|E9PN89_HUMAN;tr|E9PNE6|E9PNE6_HUMAN;tr|E9PLF4|E9PLF4_HUMAN;tr|A8K7Q2|A8K7Q2_HUMAN;tr|E9PQQ4|E9PQQ4_HUMAN;tr|E9PQK7|E9PQK7_HUMAN;tr|E9PK54|E9PK54_HUMAN;tr|E9PPY6|E9PPY6_HUMAN;tr|E9PN25|E9PN25_HUMAN;tr|E9PI65|E9PI65_HUMAN;tr|E9PS65|E9PS65_HUMAN;tr|E9PM13|E9PM13_HUMAN","sp|P11142|HSP7C_HUMAN;tr|E9PKE3|E9PKE3_HUMAN;tr|E9PN89|E9PN89_HUMAN;tr|E9PNE6|E9PNE6_HUMAN",617,"P11142","HSP7C_HUMAN","Heat shock cognate 71 kDa protein",null,"HSPA8"]
["18.0001","18.2577","18.5121","18.867",{"$nulls":4},"nucleic acid binding",{"$nulls":4},2,2,2,"3.2","3.2","3.2","93.287","0.0010826","2.4858",126210000,4,"0.903357","0.300305","-0.560636","-2.557","tr|H3BQQ2|H3BQQ2_HUMAN;sp|Q86UK7|ZN598_HUMAN;tr|H3BR87|H3BR87_HUMAN","tr|H3BQQ2|H3BQQ2_HUMAN;sp|Q86UK7|ZN598_HUMAN;tr|H3BR87|H3BR87_HUMAN",1978,"H3BQQ2","H3BQQ2_HUMAN",null,null,"ZNF598"]
["16.8236","16.9674","17.6132","17.2994",{"$nulls":3},"cell cycle;mRNA methylation;mRNA processing;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA splicing",null,"nuclear membrane;nuclear speck;nucleoplasm;nucleus;RNA N6-methyladenosine methyltransferase complex",{"$nulls":3},1,1,1,"3.8","3.8","3.8","44.243",0,"45.65",39292000,8,"1.08048","0.308477","-0.560814","-3.24924","sp|Q15007|FL2D_HUMAN","sp|Q15007|FL2D_HUMAN",1659,"Q15007","FL2D_HUMAN","Pre-mRNA-splicing regulator WTAP",null,"WTAP"]
["19.2472","19.7254","20.2658","19.8303",{"$nulls":3},"cellular response to vasopressin;negative regulation of protein export from nucleus;protein sumoylation;response to axon injury;signal transduction;sister chromatid cohesion","cadherin binding;GTPase activator activity;Ran GTPase binding;RNA binding;ubiquitin protein ligase binding","aggresome;axon cytoplasm;condensed chromosome kinetochore;cytoplasm;cytoplasmic periphery of the nuclear pore complex;cytosol;dendrite;intracellular membrane-bounded organelle;mitotic spindle;nuclear envelope;nuclear membrane;nuclear pore;nuclear pore cytoplasmic filaments;perinuclear region of cytoplasm;spindle pole","RNA transport",null,null,5,5,5,"11.4","11.4","11.4","63.541",0,"21.599",252280000,33,"0.648775","0.397524","-0.561737","-1.73709","sp|P46060|RAGP1_HUMAN;tr|B0QYT5|B0QYT5_HUMAN;tr|B0QYT4|B0QYT4_HUMAN;tr|H0Y4Q3|H0Y4Q3_HUMAN","sp|P46060|RAGP1_HUMAN",1020,"P46060","RAGP1_HUMAN","Ran GTPase-activating protein 1","anGAP1","RANGAP1"]
["15.6254","15.5062","16.6787","15.5776",{"$nulls":3},"cell adhesion;positive regulation of synapse assembly",null,"cell surface;endoplasmic reticulum;integral component of plasma membrane",{"$nulls":3},1,1,1,"4.5","4.5","4.5","46.031",0,"3.5821",9258700,2,"0.380146","0.641578","-0.562327","-1.0155","sp|Q13641|TPBG_HUMAN","sp|Q13641|TPBG_HUMAN",1582,"Q13641","TPBG_HUMAN","Trophoblast glycoprotein",null,"TPBG"]
["23.101","22.961","23.3827","23.8047",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},4,4,4,23,23,23,"20.51",0,"12.497",935410000,23,"0.896142","0.29862","-0.562705","-2.53119","tr|E7EQV9|E7EQV9_HUMAN;sp|P61313|RL15_HUMAN;tr|E7EX53|E7EX53_HUMAN;tr|E7ENU7|E7ENU7_HUMAN","tr|E7EQV9|E7EQV9_HUMAN;sp|P61313|RL15_HUMAN;tr|E7EX53|E7EX53_HUMAN;tr|E7ENU7|E7ENU7_HUMAN",1269,"E7EQV9","E7EQV9_HUMAN","Ribosomal protein L15 {ECO:0000256|RuleBase:RU000663}",null,"RPL15"]
["19.9683","19.1819","20.3433","19.9329",{"$nulls":3},"intracellular protein transport;vesicle-mediated transport","protein transporter activity","clathrin adaptor complex",{"$nulls":3},9,9,5,"14.6","14.6","9.4","101.33",0,"85.381",451910000,27,"0.47879","0.525505","-0.562973","-1.26929","tr|A0A087X253|A0A087X253_HUMAN;sp|P63010|AP2B1_HUMAN","tr|A0A087X253|A0A087X253_HUMAN;sp|P63010|AP2B1_HUMAN",1338,"A0A087X253","A0A087X253_HUMAN","AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291}",null,"AP2B1"]
["23.9795","23.6753","24.474","24.3068",{"$nulls":5},"nascent polypeptide-associated complex",{"$nulls":3},5,5,5,"51.5","51.5","51.5","15.016",0,"276.27",1279200000,34,"1.07911","0.305229","-0.562993","-3.24343","tr|F8VZJ2|F8VZJ2_HUMAN;tr|H0YHX9|H0YHX9_HUMAN;sp|Q13765|NACA_HUMAN;sp|E9PAV3|NACAM_HUMAN;tr|F8W0W4|F8W0W4_HUMAN;tr|F8W1N5|F8W1N5_HUMAN;tr|F8VNW4|F8VNW4_HUMAN;tr|F8VZ58|F8VZ58_HUMAN;sp|Q9BZK3|NACP1_HUMAN","tr|F8VZJ2|F8VZJ2_HUMAN;tr|H0YHX9|H0YHX9_HUMAN;sp|Q13765|NACA_HUMAN;sp|E9PAV3|NACAM_HUMAN;tr|F8W0W4|F8W0W4_HUMAN;tr|F8W1N5|F8W1N5_HUMAN;tr|F8VNW4|F8VNW4_HUMAN",114,"F8VZJ2","F8VZJ2_HUMAN",null,null,"NACA"]
["19.1778","19.0949","20.0765","19.3237",{"$nulls":4},"transferase activity, transferring glycosyl groups",{"$nulls":4},3,3,3,"20.7","20.7","20.7","21.51",0,"6.8608",73999000,8,"0.560745","0.471659","-0.563788","-1.48886","tr|G5E9W8|G5E9W8_HUMAN;tr|C9JQ42|C9JQ42_HUMAN;sp|P46976|GLYG_HUMAN;tr|C9J8R8|C9J8R8_HUMAN;tr|C9J7C7|C9J7C7_HUMAN","tr|G5E9W8|G5E9W8_HUMAN;tr|C9JQ42|C9JQ42_HUMAN;sp|P46976|GLYG_HUMAN",1042,"G5E9W8","G5E9W8_HUMAN"]
["17.9215","17.7582","18.8282","17.9793",{"$nulls":4},"protein tyrosine phosphatase activity",{"$nulls":4},1,1,1,"11.5","11.5","11.5","14.576",0,"3.781",22391000,7,"0.492203","0.519963","-0.563898","-1.30458","tr|F5H5H9|F5H5H9_HUMAN;tr|F5GY79|F5GY79_HUMAN;tr|F5H1Z8|F5H1Z8_HUMAN;tr|F5H0N8|F5H0N8_HUMAN;sp|P29350|PTN6_HUMAN","tr|F5H5H9|F5H5H9_HUMAN;tr|F5GY79|F5GY79_HUMAN;tr|F5H1Z8|F5H1Z8_HUMAN;tr|F5H0N8|F5H0N8_HUMAN;sp|P29350|PTN6_HUMAN",846,"F5H5H9","F5H5H9_HUMAN","Tyrosine-protein phosphatase {ECO:0000256|RuleBase:RU364084}",null,"PTPN6"]
["19.7292","19.5298","20.4175","19.9713",{"$nulls":3},"multicellular organism development;transcription, DNA-templated","GTP binding;identical protein binding;transcription factor binding","cytosol;membrane;nuclear body;polysome",{"$nulls":3},7,7,7,"27.2","27.2","27.2","40.542",0,"18.136",220240000,30,"0.832685","0.314372","-0.564865","-2.31137","sp|Q9Y295|DRG1_HUMAN","sp|Q9Y295|DRG1_HUMAN",2946,"Q9Y295","DRG1_HUMAN","Developmentally-regulated GTP-binding protein 1","RG-1","DRG1"]
["19.8599","19.9655","20.5961","20.3596",{"$nulls":3},"autophagy of mitochondrion",null,"integral component of mitochondrial outer membrane;mitochondrion;nucleus",{"$nulls":3},1,1,1,"4.8","4.8","4.8","20.675",0,"3.6043",55228000,4,"1.31253","0.335569","-0.56514","-4.36454","sp|Q9BWH2|FUND2_HUMAN","sp|Q9BWH2|FUND2_HUMAN",2486,"Q9BWH2","FUND2_HUMAN","FUN14 domain-containing protein 2",null,"FUNDC2"]
["18.0206","18.0294","18.9153","18.2677",{"$nulls":3},"intracellular protein transport;vesicle-mediated transport",null,"intracellular membrane-bounded organelle;SNARE complex",{"$nulls":3},2,2,2,"18.3","18.3","18.3","13.281","0.00039401","3.2462",19019000,3,"0.653055","0.391132","-0.566485","-1.74954","tr|B7ZBM4|B7ZBM4_HUMAN;tr|B7ZBM5|B7ZBM5_HUMAN;tr|Q96NX8|Q96NX8_HUMAN;tr|F8W9Z6|F8W9Z6_HUMAN;tr|B7ZBM8|B7ZBM8_HUMAN;sp|O14662|STX16_HUMAN;tr|H3BU86|H3BU86_HUMAN;tr|E9PND6|E9PND6_HUMAN;tr|H0YEW0|H0YEW0_HUMAN;tr|C9K0W8|C9K0W8_HUMAN","tr|B7ZBM4|B7ZBM4_HUMAN;tr|B7ZBM5|B7ZBM5_HUMAN;tr|Q96NX8|Q96NX8_HUMAN;tr|F8W9Z6|F8W9Z6_HUMAN;tr|B7ZBM8|B7ZBM8_HUMAN;sp|O14662|STX16_HUMAN;tr|H3BU86|H3BU86_HUMAN;tr|E9PND6|E9PND6_HUMAN;tr|H0YEW0|H0YEW0_HUMAN;tr|C9K0W8|C9K0W8_HUMAN",166,"B7ZBM4","B7ZBM4_HUMAN",null,null,"STX16"]
["20.9209","19.8018","21.063","20.7945",{"$nulls":3},"heme catabolic process","biliverdin reductase activity;riboflavin reductase (NADPH) activity","cytosol;extracellular exosome;nucleoplasm;plasma membrane;terminal bouton","Metabolic pathways;Porphyrin and chlorophyll metabolism;Riboflavin metabolism",null,null,3,3,3,"23.8","23.8","23.8","22.119",0,"12.392",213030000,29,"0.368509","0.659919","-0.567413","-0.986075","sp|P30043|BLVRB_HUMAN;tr|M0QZL1|M0QZL1_HUMAN;tr|M0R192|M0R192_HUMAN","sp|P30043|BLVRB_HUMAN",857,"P30043","BLVRB_HUMAN","Flavin reductase (NADPH)","R","BLVRB"]
["21.1854","21.2484","21.6315","21.9377",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational elongation;translational initiation;viral transcription","structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;membrane","Ribosome",null,null,3,3,3,"55.7","55.7","55.7","11.665",0,"5.8018",142260000,20,"1.16647","0.31738","-0.567705","-3.63164","sp|P05387|RLA2_HUMAN;tr|H0YDD8|H0YDD8_HUMAN","sp|P05387|RLA2_HUMAN;tr|H0YDD8|H0YDD8_HUMAN",519,"P05387","RLA2_HUMAN","60S acidic ribosomal protein P2",null,"RPLP2"]
["21.8426","21.5034","22.4552","22.0277",{"$nulls":5},"endoplasmic reticulum tubular network;extracellular exosome;integral component of membrane",{"$nulls":3},1,1,1,"5.3","5.3","5.3","21.493","0.0072896","1.8102",276990000,2,"0.762799","0.336921","-0.568367","-2.08299","sp|Q00765|REEP5_HUMAN","sp|Q00765|REEP5_HUMAN",1409,"Q00765","REEP5_HUMAN","Receptor expression-enhancing protein 5",null,"REEP5"]
["27.038","26.8576","27.7083","27.3241",{"$nulls":3},"cellular response to drug;cellular response to interleukin-4;cellular response to organic cyclic compound;chaperone-mediated protein complex assembly;Fc-gamma receptor signaling pathway involved in phagocytosis;negative regulation of cell cycle arrest;negative regulation of complement-dependent cytotoxicity;negative regulation of neuron apoptotic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of transforming growth factor beta activation;neutrophil degranulation;placenta development;positive regulation of cell differentiation;positive regulation of cell size;positive regulation of nitric oxide biosynthetic process;positive regulation of phosphoprotein phosphatase activity;positive regulation of protein binding;positive regulation of protein import into nucleus, translocation;positive regulation of protein localization to cell surface;positive regulation of protein serine/threonine kinase activity;positive regulation of telomerase activity;positive regulation of transforming growth factor beta receptor signaling pathway;protein folding;protein stabilization;regulation of cellular response to heat;regulation of interferon-gamma-mediated signaling pathway;regulation of protein ubiquitination;regulation of type I interferon-mediated signaling pathway;response to cocaine;response to salt stress;response to unfolded protein;supramolecular fiber organization;telomerase holoenzyme complex assembly;telomere maintenance via telomerase;virion attachment to host cell;xenobiotic metabolic process","ATP binding;ATP-dependent protein binding;cadherin binding;CTP binding;dATP binding;disordered domain specific binding;DNA polymerase binding;double-stranded RNA binding;drug binding;GTP binding;heat shock protein binding;histone deacetylase binding;histone methyltransferase binding;identical protein binding;ion channel binding;kinase binding;MHC class II protein complex binding;nitric-oxide synthase regulator activity;peptide binding;protein dimerization activity;protein homodimerization activity;protein kinase binding;protein kinase regulator activity;RNA binding;sulfonylurea receptor binding;TPR domain binding;unfolded protein binding;UTP binding","apical plasma membrane;aryl hydrocarbon receptor complex;basolateral plasma membrane;brush border membrane;cell surface;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;inclusion body;lysosomal membrane;melanosome;membrane;mitochondrion;nucleoplasm;nucleus;ooplasm;protein complex;secretory granule lumen;sperm head plasma membrane","Antigen processing and presentation;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;IL-17 signaling pathway;Necroptosis;NOD-like receptor signaling pathway;Pathways in cancer;PI3K-Akt signaling pathway;Progesterone-mediated oocyte maturation;Prostate cancer;Protein processing in endoplasmic reticulum;Th17 cell differentiation",null,null,32,32,16,"48.9","48.9","27.9","83.263",0,"323.31",58144000000,400,"0.936528","0.297755","-0.56841","-2.67787","sp|P08238|HS90B_HUMAN;sp|Q58FF7|H90B3_HUMAN","sp|P08238|HS90B_HUMAN",559,"P08238","HS90B_HUMAN","Heat shock protein HSP 90-beta","SP 90","HSP90AB1"]
["19.6404","20.0074","20.4917","20.2957",{"$nulls":3},"immune response;negative regulation of cysteine-type endopeptidase activity","cysteine-type endopeptidase inhibitor activity;endopeptidase inhibitor activity;protease binding","cytoplasm;extracellular space",{"$nulls":3},1,1,1,"7.6","7.6","7.6","16.454",0,"5.6189",86476000,5,"0.95279","0.296275","-0.56979","-2.73851","sp|O76096|CYTF_HUMAN","sp|O76096|CYTF_HUMAN",389,"O76096","CYTF_HUMAN","Cystatin-F",null,"CST7"]
["19.7313","20.2377","20.2377","20.8716",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrion;ribosome",{"$nulls":3},3,3,3,"25.7","25.7","25.7","25.65",0,"12.791",132760000,23,"0.53004","0.498747","-0.570144","-1.40545","sp|P82930|RT34_HUMAN;tr|C9JJ19|C9JJ19_HUMAN;tr|A0A087WUZ8|A0A087WUZ8_HUMAN","sp|P82930|RT34_HUMAN;tr|C9JJ19|C9JJ19_HUMAN",1385,"P82930","RT34_HUMAN","28S ribosomal protein S34, mitochondrial","34mt;RP-S34","MRPS34"]
["18.587","18.0735","19.129","18.6721",{"$nulls":4},"ATP binding;metal ion binding","nucleus",{"$nulls":3},16,16,14,"12.4","12.4","10.5","217.1",0,"67.221",444750000,50,"0.621724","0.422192","-0.570263","-1.65925","tr|F5GWX5|F5GWX5_HUMAN;sp|Q14839|CHD4_HUMAN;tr|A0A0C4DGG9|A0A0C4DGG9_HUMAN;sp|Q8TDI0|CHD5_HUMAN;tr|K7EMY3|K7EMY3_HUMAN;tr|F2Z2R5|F2Z2R5_HUMAN","tr|F5GWX5|F5GWX5_HUMAN;sp|Q14839|CHD4_HUMAN;tr|A0A0C4DGG9|A0A0C4DGG9_HUMAN",1647,"F5GWX5","F5GWX5_HUMAN",null,null,"CHD4"]
["24.6021","24.3087","25.3088","24.7427",{"$nulls":3},"microtubule-based process","GTP binding;GTPase activity;structural constituent of cytoskeleton","microtubule;microtubule cytoskeleton",{"$nulls":3},21,5,4,"62.7","20.2","16.7","47.766",0,"196.4",6265500000,120,"0.666619","0.388777","-0.570365","-1.78926","tr|Q5JP53|Q5JP53_HUMAN;sp|P07437|TBB5_HUMAN;tr|Q5ST81|Q5ST81_HUMAN","tr|Q5JP53|Q5JP53_HUMAN;sp|P07437|TBB5_HUMAN;tr|Q5ST81|Q5ST81_HUMAN",544,"Q5JP53","Q5JP53_HUMAN","Tubulin beta chain {ECO:0000256|RuleBase:RU000352}",null,"TUBB"]
["18.987","18.3828","19.8388","18.6737",{"$nulls":3},"neutrophil degranulation;proteolysis","dipeptidyl-peptidase activity;serine-type peptidase activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region;Golgi apparatus;intracellular membrane-bounded organelle;vesicle",{"$nulls":3},4,4,4,"8.9","8.9","8.9","54.341",0,"6.1069",96948000,12,"0.322621","0.708438","-0.571323","-0.870634","sp|Q9UHL4|DPP2_HUMAN;tr|R4GNE8|R4GNE8_HUMAN;tr|R4GMV4|R4GMV4_HUMAN;tr|R4GN05|R4GN05_HUMAN","sp|Q9UHL4|DPP2_HUMAN;tr|R4GNE8|R4GNE8_HUMAN",2836,"Q9UHL4","DPP2_HUMAN","Dipeptidyl peptidase 2",null,"DPP7"]
["18.5944","19.217","19.8867","19.0678",{"$nulls":3},"associative learning;cellular response to brain-derived neurotrophic factor stimulus;cellular response to selenite ion;embryonic cranial skeleton morphogenesis;exploration behavior;mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;negative regulation of excitatory postsynaptic potential;negative regulation of selenocysteine incorporation;negative regulation of selenocysteine insertion sequence binding;negative regulation of translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of translation;response to organic cyclic compound;RNA export from nucleus;RNA secondary structure unwinding;RNA splicing;rRNA processing;termination of RNA polymerase II transcription","ATP binding;ATP-dependent RNA helicase activity;mRNA binding;poly(A) binding;ribonucleoprotein complex binding;RNA binding;RNA stem-loop binding;selenocysteine insertion sequence binding","catalytic step 2 spliceosome;cytoplasm;cytosol;dendrite;exon-exon junction complex;membrane;neuronal cell body;nuclear speck;nucleolus;nucleoplasm","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,7,5,5,"22.6","18.5","18.5","46.871",0,"12.095",96241000,8,"0.417751","0.599255","-0.571543","-1.11121","sp|P38919|IF4A3_HUMAN;tr|I3L3H2|I3L3H2_HUMAN","sp|P38919|IF4A3_HUMAN",960,"P38919","IF4A3_HUMAN","Eukaryotic initiation factor 4A-III","IF4A-III;IF-4A-III","EIF4A3"]
["18.4729","18.2666","19.005","18.8789",{"$nulls":4},"RNA binding",{"$nulls":4},2,2,2,"9.3","9.3","9.3","38.093",0,"25.453",64164000,16,"1.37834","0.33492","-0.572211","-4.73367","tr|H0YA82|H0YA82_HUMAN;sp|Q4G0J3|LARP7_HUMAN;tr|D6R9Z6|D6R9Z6_HUMAN;tr|D6RFF0|D6RFF0_HUMAN","tr|H0YA82|H0YA82_HUMAN;sp|Q4G0J3|LARP7_HUMAN;tr|D6R9Z6|D6R9Z6_HUMAN;tr|D6RFF0|D6RFF0_HUMAN",1786,"H0YA82","H0YA82_HUMAN",null,null,"LARP7"]
["17.9308","17.7173","18.3198","18.4729",{"$nulls":9},4,4,4,"14.8","14.8","14.8","52.175",0,"9.4055",59954000,15,"1.31121","0.334443","-0.572328","-4.3574","tr|F6T1Q0|F6T1Q0_HUMAN;sp|Q6L8Q7|PDE12_HUMAN","tr|F6T1Q0|F6T1Q0_HUMAN;sp|Q6L8Q7|PDE12_HUMAN",1874,"F6T1Q0","F6T1Q0_HUMAN",null,null,"PDE12"]
["21.8864","21.5282","22.3112","22.2501",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},2,2,2,"20.6","20.6","20.6","15.197",0,"15.732",249140000,15,"1.05823","0.305729","-0.573302","-3.1556","tr|E7ETK0|E7ETK0_HUMAN;tr|A0A087WUS0|A0A087WUS0_HUMAN;sp|P62847|RS24_HUMAN","tr|E7ETK0|E7ETK0_HUMAN;tr|A0A087WUS0|A0A087WUS0_HUMAN;sp|P62847|RS24_HUMAN",1320,"E7ETK0","E7ETK0_HUMAN","40S ribosomal protein S24 {ECO:0000256|RuleBase:RU004383}",null,"RPS24"]
["20.601","20.7778","21.584","20.9433",{"$nulls":3},"brainstem development;cerebellum development;cerebral cortex development;'de novo' IMP biosynthetic process;glycine metabolic process;purine nucleobase biosynthetic process;purine ribonucleoside monophosphate biosynthetic process;response to inorganic substance;response to organic substance;tetrahydrofolate biosynthetic process","ATP binding;metal ion binding;phosphoribosylamine-glycine ligase activity;phosphoribosylformylglycinamidine cyclo-ligase activity;phosphoribosylglycinamide formyltransferase activity","cytosol;extracellular exosome","Antifolate resistance;Metabolic pathways;One carbon pool by folate;Purine metabolism",null,null,20,20,20,"28.5","28.5","28.5","107.77",0,"94.001",1209200000,94,"0.645583","0.400883","-0.57423","-1.72783","sp|P22102|PUR2_HUMAN;tr|F8WD69|F8WD69_HUMAN;tr|C9JBJ1|C9JBJ1_HUMAN;tr|C9JTV6|C9JTV6_HUMAN;tr|C9JZG2|C9JZG2_HUMAN;tr|C9JKQ7|C9JKQ7_HUMAN;tr|H7C366|H7C366_HUMAN","sp|P22102|PUR2_HUMAN",762,"P22102","PUR2_HUMAN","Trifunctional purine biosynthetic protein adenosine-3",null,"GART"]
["17.4883","17.2329","18.5796","17.2907",{"$nulls":3},"7-methylguanosine mRNA capping;cell cycle;chromatin remodeling;DNA-templated transcription, elongation;negative regulation of DNA-templated transcription, elongation;negative regulation of mRNA polyadenylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of DNA-templated transcription, elongation;positive regulation of macroautophagy;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral transcription;response to organic substance;single stranded viral RNA replication via double stranded DNA intermediate;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","chromatin binding;DNA binding;enzyme binding;mRNA binding;protein heterodimerization activity;RNA binding","DSIF complex;nucleoplasm;nucleus",{"$nulls":3},9,9,9,"15.2","15.2","15.2",121,0,"22.627",103800000,32,"0.324146","0.709017","-0.574512","-0.874459","sp|O00267|SPT5H_HUMAN;tr|M0QYL9|M0QYL9_HUMAN","sp|O00267|SPT5H_HUMAN",131,"O00267","SPT5H_HUMAN","Transcription elongation factor SPT5","SPT5","SUPT5H"]
["20.3883","20.7248","21.232","21.0305",{"$nulls":9},6,6,6,"12.3","12.3","12.3","46.913",0,"39.566",454940000,32,"1.00249","0.29419","-0.574668","-2.92981","tr|E7ETZ4|E7ETZ4_HUMAN;sp|Q9Y6E2|BZW2_HUMAN;tr|B5MCE7|B5MCE7_HUMAN;tr|B5MCH7|B5MCH7_HUMAN;tr|Q75MG1|Q75MG1_HUMAN;tr|E9PFD4|E9PFD4_HUMAN;tr|E7EMS9|E7EMS9_HUMAN;tr|E9PFE3|E9PFE3_HUMAN;tr|C9JF98|C9JF98_HUMAN;tr|F8WDX8|F8WDX8_HUMAN","tr|E7ETZ4|E7ETZ4_HUMAN;sp|Q9Y6E2|BZW2_HUMAN;tr|B5MCE7|B5MCE7_HUMAN;tr|B5MCH7|B5MCH7_HUMAN;tr|Q75MG1|Q75MG1_HUMAN;tr|E9PFD4|E9PFD4_HUMAN",3049,"E7ETZ4","E7ETZ4_HUMAN",null,null,"BZW2"]
["16.2646","16.2882","17.2672","16.4352",{"$nulls":3},"intracellular signal transduction","ATP binding;magnesium ion binding;protein serine/threonine kinase activity","cytosol;nucleus",{"$nulls":3},5,3,3,"9.3","6.6","6.6","81.471",0,"5.1051",41785000,7,"0.52103","0.503236","-0.574826","-1.38125","tr|E9PGT3|E9PGT3_HUMAN;sp|Q15418|KS6A1_HUMAN","tr|E9PGT3|E9PGT3_HUMAN;sp|Q15418|KS6A1_HUMAN",1701,"E9PGT3","E9PGT3_HUMAN","Ribosomal protein S6 kinase {ECO:0000256|PIRNR:PIRNR000606}",null,"RPS6KA1"]
["17.7001","17.4244","18.1879","18.0885",{"$nulls":3},"intracellular protein transport;vesicle-mediated transport",null,"clathrin adaptor complex",{"$nulls":3},2,2,2,"7.1","7.1","7.1","40.296",0,"4.1917",49835000,13,"1.2288","0.316034","-0.57594","-3.93074","tr|K7EJL1|K7EJL1_HUMAN;tr|E7ENJ6|E7ENJ6_HUMAN;sp|Q9BXS5|AP1M1_HUMAN","tr|K7EJL1|K7EJL1_HUMAN;tr|E7ENJ6|E7ENJ6_HUMAN;sp|Q9BXS5|AP1M1_HUMAN",2499,"K7EJL1","K7EJL1_HUMAN",null,null,"AP1M1"]
["18.8995","19.1164","19.9607","19.2075",{"$nulls":3},"positive regulation of cell proliferation;positive regulation of gene expression;protein methylation;tRNA splicing, via endonucleolytic cleavage and ligation","identical protein binding;protein methyltransferase activity;RNA binding","cytoplasm;intracellular membrane-bounded organelle;nucleoplasm;nucleus;tRNA-splicing ligase complex",{"$nulls":3},1,1,1,"3.9","3.9","3.9","37.19",0,"15.767",88455000,12,"0.553898","0.474064","-0.576141","-1.47013","sp|Q52LJ0|FA98B_HUMAN","sp|Q52LJ0|FA98B_HUMAN",1790,"Q52LJ0","FA98B_HUMAN","Protein FAM98B",null,"FAM98B"]
["22.6651","22.8112","23.5289","23.1012",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of transferase activity;protein methylation;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;enzyme binding;fibroblast growth factor binding;mRNA binding;RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;focal adhesion;membrane;nucleoplasm;nucleus","Ribosome",null,null,9,9,9,"34.8","34.8","34.8","31.324",0,"35.18",1557300000,42,"0.9021","0.300537","-0.576833","-2.55249","sp|P15880|RS2_HUMAN;tr|H0YEN5|H0YEN5_HUMAN;tr|E9PQD7|E9PQD7_HUMAN;tr|I3L404|I3L404_HUMAN;tr|E9PMM9|E9PMM9_HUMAN;tr|E9PPT0|E9PPT0_HUMAN;tr|E9PM36|E9PM36_HUMAN;tr|H3BNG3|H3BNG3_HUMAN;tr|H0YE27|H0YE27_HUMAN","sp|P15880|RS2_HUMAN;tr|H0YEN5|H0YEN5_HUMAN;tr|E9PQD7|E9PQD7_HUMAN",689,"P15880","RS2_HUMAN","40S ribosomal protein S2",null,"RPS2"]
["17.8533","17.7743","18.9295","17.853",{"$nulls":5},"cytosol;microtubule organizing center",{"$nulls":3},11,11,11,"12.3","12.3","12.3","145.17",0,"48.98",257450000,49,"0.401592","0.621545","-0.577429","-1.06995","tr|A0A087X2D8|A0A087X2D8_HUMAN;sp|O60271|JIP4_HUMAN;tr|D6RHI8|D6RHI8_HUMAN;tr|H0YBE9|H0YBE9_HUMAN;tr|H0YBS5|H0YBS5_HUMAN","tr|A0A087X2D8|A0A087X2D8_HUMAN;sp|O60271|JIP4_HUMAN",284,"A0A087X2D8","A0A087X2D8_HUMAN",null,null,"SPAG9"]
["22.5687","22.4779","23.1625","23.0402",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;osteoblast differentiation;positive regulation of canonical Wnt signaling pathway;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent ERAD pathway;ubiquitin-dependent protein catabolic process;viral process;Wnt signaling pathway, planar cell polarity pathway","ATP binding;ATPase activity;proteasome-activating ATPase activity;TBP-class protein binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;cytosolic proteasome complex;extracellular region;ficolin-1-rich granule lumen;membrane;nuclear proteasome complex;nucleoplasm;nucleus;P-body;proteasome accessory complex;proteasome complex;proteasome regulatory particle, base subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,16,16,16,"46.4","46.4","46.4","48.633",0,"117.41",2472100000,74,"1.7716","0.357265","-0.578065","-7.58987","sp|P35998|PRS7_HUMAN;tr|C9JLS9|C9JLS9_HUMAN","sp|P35998|PRS7_HUMAN",941,"P35998","PRS7_HUMAN","26S proteasome regulatory subunit 7",null,"PSMC2"]
["18.845","18.3002","19.9703","18.3315",{"$nulls":4},"nucleic acid binding",{"$nulls":4},2,2,2,"14.7","14.7","14.7","20.732",0,"6.8049",75280000,9,"0.242586","0.784591","-0.578266","-0.669679","tr|H0YJV7|H0YJV7_HUMAN;sp|P25490|TYY1_HUMAN;tr|H0YJU4|H0YJU4_HUMAN;sp|O15391|TYY2_HUMAN","tr|H0YJV7|H0YJV7_HUMAN;sp|P25490|TYY1_HUMAN;tr|H0YJU4|H0YJU4_HUMAN;sp|O15391|TYY2_HUMAN",797,"H0YJV7","H0YJV7_HUMAN",null,null,"YY1"]
["19.5329","19.7008","20.49","19.901",{"$nulls":3},"activation of MAPK activity;ERK1 and ERK2 cascade;MAPK cascade;negative regulation of gene expression;peptidyl-serine autophosphorylation;positive regulation of ERK1 and ERK2 cascade;positive regulation of production of miRNAs involved in gene silencing by miRNA;positive regulation of protein serine/threonine kinase activity;positive regulation of transcription, DNA-templated;proteolysis in other organism;regulation of apoptotic process;regulation of early endosome to late endosome transport;regulation of Golgi inheritance;regulation of mitotic cell cycle;regulation of stress-activated MAPK cascade","ATP binding;MAP kinase kinase activity;metal ion binding;PDZ domain binding;protein serine/threonine kinase activator activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity;scaffold protein binding","cell-cell junction;cytoplasmic side of plasma membrane;cytosol;early endosome;endoplasmic reticulum;extracellular region;focal adhesion;Golgi apparatus;late endosome;microtubule;mitochondrion;nucleus;perinuclear region of cytoplasm;peroxisomal membrane;plasma membrane","Acute myeloid leukemia;Apelin signaling pathway;Apoptosis;Autophagy - animal;B cell receptor signaling pathway;Bladder cancer;Breast cancer;cAMP signaling pathway;Cellular senescence;Central carbon metabolism in cancer;cGMP-PKG signaling pathway;Choline metabolism in cancer;Chronic myeloid leukemia;Colorectal cancer;Cushing syndrome;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;MicroRNAs in cancer;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-small cell lung cancer;Oxytocin signaling pathway;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prion diseases;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid cancer;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Yersinia infection",null,null,3,3,2,"9.8","9.8","7.5","44.424",0,"7.6667",218480000,19,"0.700256","0.366386","-0.578672","-1.8895","sp|P36507|MP2K2_HUMAN;tr|G5E9C7|G5E9C7_HUMAN;tr|M0R1B6|M0R1B6_HUMAN","sp|P36507|MP2K2_HUMAN;tr|G5E9C7|G5E9C7_HUMAN",942,"P36507","MP2K2_HUMAN","Dual specificity mitogen-activated protein kinase kinase 2","AP kinase kinase 2;APKK 2","MAP2K2"]
["18.9113","19.171","19.9412","19.2993",{"$nulls":3},"regulation of cytoplasmic mRNA processing body assembly;stress granule assembly","cadherin binding;RNA binding","cytoplasmic stress granule;cytosol;membrane;nuclear speck",{"$nulls":3},9,9,9,"12.5","12.5","12.5","113.37",0,"33.359",282910000,32,"0.626487","0.418072","-0.579131","-1.67285","sp|Q8WWM7|ATX2L_HUMAN;tr|H3BUF6|H3BUF6_HUMAN;tr|H3BSK9|H3BSK9_HUMAN;tr|H3BRB0|H3BRB0_HUMAN;tr|A0A0C4DGL7|A0A0C4DGL7_HUMAN","sp|Q8WWM7|ATX2L_HUMAN;tr|H3BUF6|H3BUF6_HUMAN;tr|H3BSK9|H3BSK9_HUMAN",2152,"Q8WWM7","ATX2L_HUMAN","Ataxin-2-like protein",null,"ATXN2L"]
["14.9818","15.0895","15.9035","15.3267",{"$nulls":3},"autophagosome assembly;autophagy;autophagy of mitochondrion;autophagy of peroxisome;cell cycle;glycophagy;heart development;liver development;macroautophagy;negative regulation of extrinsic apoptotic signaling pathway;positive regulation of cell size;positive regulation of JNK cascade;positive regulation of protein phosphorylation;regulation of macroautophagy;regulation of transcription, DNA-templated;reticulophagy;transcription, DNA-templated","protein complex scaffold activity;protein kinase binding","Atg1/ULK1 kinase complex;cytosol;endoplasmic reticulum membrane;nuclear membrane;phagophore assembly site membrane","Autophagy - animal;Longevity regulating pathway",null,null,2,2,2,"1.9","1.9","1.9","183.09",0,"4.9531",34442000,2,"0.728348","0.351368","-0.579474","-1.97521","sp|Q8TDY2|RBCC1_HUMAN","sp|Q8TDY2|RBCC1_HUMAN",2122,"Q8TDY2","RBCC1_HUMAN","RB1-inducible coiled-coil protein 1",null,"RB1CC1"]
["17.9737","17.681","18.6002","18.2143",{"$nulls":4},"ATP binding;nucleoside-triphosphatase activity;nucleotide phosphatase activity, acting on free nucleotides;RNA binding","extracellular exosome;membrane","Metabolic pathways;Purine metabolism;Thiamine metabolism",null,null,1,1,1,"7.9","7.9","7.9","20.713","0.005353","1.8845",27585000,6,"0.857101","0.303923","-0.57987","-2.39447","sp|Q9BSD7|NTPCR_HUMAN;tr|Q5TDF0|Q5TDF0_HUMAN","sp|Q9BSD7|NTPCR_HUMAN;tr|Q5TDF0|Q5TDF0_HUMAN",2434,"Q9BSD7","NTPCR_HUMAN","Cancer-related nucleoside-triphosphatase","TPase","NTPCR"]
["18.1322","17.8761","18.4194","18.7501",{"$nulls":3},"cell adhesion;mRNA 3'-end processing;mRNA export from nucleus;mRNA polyadenylation;mRNA splicing, via spliceosome;positive regulation of protein dephosphorylation;termination of RNA polymerase II transcription",null,"bicellular tight junction;cytoplasm;cytoskeleton;cytosol;nuclear stress granule;nucleoplasm;plasma membrane","mRNA surveillance pathway;Tight junction",null,null,7,7,7,"9.6","9.6","9.6","141.15",0,"83.241",254770000,20,"0.962686","0.293347","-0.580549","-2.77588","sp|Q92797|SYMPK_HUMAN;tr|A0A087WUE9|A0A087WUE9_HUMAN;tr|M0R3C7|M0R3C7_HUMAN;tr|M0R1C2|M0R1C2_HUMAN;tr|M0R180|M0R180_HUMAN;tr|M0QXP5|M0QXP5_HUMAN","sp|Q92797|SYMPK_HUMAN;tr|A0A087WUE9|A0A087WUE9_HUMAN",2192,"Q92797","SYMPK_HUMAN","Symplekin",null,"SYMPK"]
["18.1593","17.458","18.6909","18.0881",{"$nulls":9},1,1,1,"8.5","8.5","8.5","16.921",0,"4.5591",23276000,5,"0.473786","0.53073","-0.580812","-1.25618","tr|I3L245|I3L245_HUMAN;tr|J3KMX1|J3KMX1_HUMAN;sp|Q99567|NUP88_HUMAN","tr|I3L245|I3L245_HUMAN;tr|J3KMX1|J3KMX1_HUMAN;sp|Q99567|NUP88_HUMAN",2382,"I3L245","I3L245_HUMAN",null,null,"NUP88"]
["18.7643","18.8069","19.2223","19.5113",{"$nulls":3},"negative regulation of transcription elongation from RNA polymerase II promoter;positive regulation of viral transcription;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","RNA binding","cytoplasm;NELF complex;nucleoplasm",{"$nulls":3},2,2,2,"4.8","4.8","4.8","65.697",0,"17.357",141820000,11,"1.23856","0.317691","-0.581182","-3.97938","sp|Q8WX92|NELFB_HUMAN","sp|Q8WX92|NELFB_HUMAN",2154,"Q8WX92","NELFB_HUMAN","Negative elongation factor B","ELF-B","NELFB"]
["19.3428","19.875","20.4541","19.9266",{"$nulls":3},"regulation of transcription, DNA-templated;response to hypoxia;response to oxidative stress","cadherin binding involved in cell-cell adhesion;metal ion binding;transcription coactivator activity","cell-cell adherens junction;cytoskeleton;focal adhesion;transcription factor complex;Z disc",{"$nulls":3},4,4,4,"23.1","23.1","23.1","36.071",0,"44.409",184200000,23,"0.583497","0.452533","-0.581406","-1.55166","sp|O00151|PDLI1_HUMAN","sp|O00151|PDLI1_HUMAN",117,"O00151","PDLI1_HUMAN","PDZ and LIM domain protein 1",null,"PDLIM1"]
["20.9426","20.4223","21.4406","21.0934",{"$nulls":3},"blood coagulation;cellular response to nerve growth factor stimulus;cholesterol homeostasis;cilium assembly;endocytic recycling;endocytosis;intracellular protein transport;low-density lipoprotein particle clearance;neuron projection development;positive regulation of cholesterol storage;positive regulation of endocytic recycling;positive regulation of myoblast fusion;protein homooligomerization;protein localization to cilium","ATP binding;cadherin binding;calcium ion binding;GTP binding;identical protein binding;Rab GTPase binding","ciliary pocket membrane;early endosome membrane;endosome membrane;extracellular exosome;lipid droplet;membrane;plasma membrane;platelet dense tubular network membrane;recycling endosome membrane","Endocytosis",null,null,12,12,12,"34.8","34.8","34.8","60.626",0,"35.54",718210000,46,"0.693418","0.373885","-0.584484","-1.86891","sp|Q9H4M9|EHD1_HUMAN;tr|A0A024R571|A0A024R571_HUMAN;tr|C9JC03|C9JC03_HUMAN;tr|C9J2Z4|C9J2Z4_HUMAN;tr|C9JIJ3|C9JIJ3_HUMAN;tr|C9IZH1|C9IZH1_HUMAN;tr|C9JDQ8|C9JDQ8_HUMAN;sp|Q9NZN3|EHD3_HUMAN;tr|A0A0C4DH83|A0A0C4DH83_HUMAN","sp|Q9H4M9|EHD1_HUMAN;tr|A0A024R571|A0A024R571_HUMAN;tr|C9JC03|C9JC03_HUMAN;tr|C9J2Z4|C9J2Z4_HUMAN",2600,"Q9H4M9","EHD1_HUMAN","EH domain-containing protein 1 {ECO:0000305}",null,"EHD1"]
["16.7908","16.327","17.4841","16.8039",{"$nulls":3},"[2Fe-2S] cluster assembly;iron incorporation into metallo-sulfur cluster;molybdopterin cofactor biosynthetic process;Mo-molybdopterin cofactor biosynthetic process;protein complex assembly;small molecule metabolic process;sulfur amino acid metabolic process","cysteine desulfurase activity;iron-sulfur cluster binding;metal ion binding;protein homodimerization activity;pyridoxal phosphate binding","cytosol;mitochondrial matrix;mitochondrion;nucleoplasm;nucleus","Metabolic pathways;Sulfur relay system;Thiamine metabolism",null,null,3,3,3,"9.4","9.4","9.4","50.195",0,"4.0509",37669000,10,"0.5359","0.491701","-0.585052","-1.42126","sp|Q9Y697|NFS1_HUMAN;tr|H7C0I5|H7C0I5_HUMAN;tr|H0YGN5|H0YGN5_HUMAN;tr|F2Z2E7|F2Z2E7_HUMAN","sp|Q9Y697|NFS1_HUMAN;tr|H7C0I5|H7C0I5_HUMAN;tr|H0YGN5|H0YGN5_HUMAN",3043,"Q9Y697","NFS1_HUMAN","Cysteine desulfurase, mitochondrial",null,"NFS1"]
["20.1552","19.8493","20.7099","20.4654",{"$nulls":3},"dendritic spine development;embryonic process involved in female pregnancy;fatty acid transport;lipid biosynthetic process;lipid metabolic process;long-chain fatty-acyl-CoA biosynthetic process;negative regulation of prostaglandin secretion;positive regulation of cell growth;response to interleukin-15;response to nutrient;triglyceride metabolic process","arachidonate-CoA ligase activity;ATP binding;decanoate--CoA ligase activity;long-chain fatty acid-CoA ligase activity;very long-chain fatty acid-CoA ligase activity","cytoplasm;endoplasmic reticulum membrane;ER-mitochondrion membrane contact site;extracellular exosome;integral component of membrane;lipid droplet;membrane;mitochondrial outer membrane;neuronal cell body;peroxisomal membrane","Adipocytokine signaling pathway;Fatty acid biosynthesis;Fatty acid degradation;Fatty acid metabolism;Ferroptosis;Metabolic pathways;Peroxisome;PPAR signaling pathway;Thermogenesis",null,null,12,12,10,"23.2","23.2","19.1","79.187",0,"105.37",699080000,50,"1.01752","0.295941","-0.585427","-2.98948","sp|O60488|ACSL4_HUMAN;tr|H0Y9A0|H0Y9A0_HUMAN;tr|D6RFW9|D6RFW9_HUMAN;tr|D6RDA8|D6RDA8_HUMAN;tr|D6RD96|D6RD96_HUMAN;tr|D6RF95|D6RF95_HUMAN","sp|O60488|ACSL4_HUMAN",288,"O60488","ACSL4_HUMAN","Long-chain-fatty-acid--CoA ligase 4",null,"ACSL4"]
["18.5671","17.2941","18.0504","18.9825",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},3,3,2,"5.9","5.9","4.6","68.326",0,"12.148",109440000,9,"0.271547","0.756685","-0.585793","-0.742552","tr|B4DXZ6|B4DXZ6_HUMAN;sp|P51114|FXR1_HUMAN;tr|C9JAJ4|C9JAJ4_HUMAN;tr|H7C4S4|H7C4S4_HUMAN","tr|B4DXZ6|B4DXZ6_HUMAN;sp|P51114|FXR1_HUMAN",1128,"B4DXZ6","B4DXZ6_HUMAN",null,null,"FXR1"]
["18.9857","18.8983","19.8348","19.2217",{"$nulls":3},"B cell activation;cell proliferation;exocytosis","cytokine activity;high molecular weight B cell growth factor receptor binding;syntaxin binding","cytoplasm;cytosol;extracellular region;membrane",{"$nulls":3},8,8,8,"23.3","23.3","23.3","61.89",0,"28.493",222960000,29,"0.701568","0.366493","-0.586283","-1.89346","sp|P40222|TXLNA_HUMAN","sp|P40222|TXLNA_HUMAN",968,"P40222","TXLNA_HUMAN","Alpha-taxilin",null,"TXLNA"]
["16.5708","14.0116","17.1432","14.6119",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;regulation of protein kinase activity",null,"cytosol",{"$nulls":3},2,2,2,"3.8","3.8","3.8","109.68",0,"13.267",30802000,7,"0.110417","0.906728","-0.586377","-0.325803","sp|Q8ND04|SMG8_HUMAN;tr|J3KTD7|J3KTD7_HUMAN","sp|Q8ND04|SMG8_HUMAN;tr|J3KTD7|J3KTD7_HUMAN",2085,"Q8ND04","SMG8_HUMAN","Protein SMG8",null,"SMG8"]
["19.6421","18.8582","20.1734","19.5001",{"$nulls":3},"apoptotic process;axonal transport of mitochondrion;cellular response to glucose stimulus;cellular response to hypoxia;cellular response to L-glutamate;cellular senescence;cochlea development;dynamin family protein polymerization involved in mitochondrial fission;GTP metabolic process;inner mitochondrial membrane organization;intracellular distribution of mitochondria;membrane tubulation;mitochondrial calcium uptake;mitochondrial fission;mitochondrial fusion;mitochondrial genome maintenance;mitochondrion morphogenesis;mitochondrion organization;negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;negative regulation of release of cytochrome c from mitochondria;positive regulation of dendritic spine morphogenesis;positive regulation of glucose import in response to insulin stimulus;positive regulation of mitochondrial fusion;positive regulation of neuron maturation;protein oligomerization;regulation of apoptotic process;response to electrical stimulus;response to muscle activity;response to nutrient levels;retina development in camera-type eye;visual perception","cardiolipin binding;GTP binding;GTPase activity;kinase binding;magnesium ion binding;microtubule binding;phosphatidic acid binding","axon cytoplasm;cytosol;dendrite;extrinsic component of mitochondrial inner membrane;integral component of membrane;membrane;mitochondrial crista;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial outer membrane;mitochondrion;nucleoplasm",{"$nulls":3},9,9,1,"11.2","11.2","1.4","111.82",0,"50.632",327090000,29,"0.42714","0.587627","-0.58659","-1.13528","tr|E5KLK1|E5KLK1_HUMAN;tr|E5KLJ9|E5KLJ9_HUMAN;tr|E5KLJ5|E5KLJ5_HUMAN;tr|E5KLJ6|E5KLJ6_HUMAN;tr|H7C141|H7C141_HUMAN","tr|E5KLK1|E5KLK1_HUMAN;tr|E5KLJ9|E5KLJ9_HUMAN;tr|E5KLJ5|E5KLJ5_HUMAN;tr|E5KLJ6|E5KLJ6_HUMAN",3080,"E5KLK1","OPA1_HUMAN","Dynamin-like 120 kDa protein, mitochondrial",null,"OPA1"]
["17.6776","17.0767","18.6152","17.3139",{"$nulls":3},"cellular response to oxidative stress;immune response;middle ear morphogenesis;miRNA metabolic process;negative regulation of cell proliferation;outer ear morphogenesis;positive regulation of intrinsic apoptotic signaling pathway;pre-miRNA processing;production of miRNAs involved in gene silencing by miRNA;production of siRNA involved in RNA interference;protein phosphorylation;protein stabilization;response to virus;skeletal system morphogenesis","double-stranded RNA binding;enzyme activator activity;enzyme binding;identical protein binding;pre-miRNA binding;protein homodimerization activity;RNA binding","cytoplasm;cytosol;membrane;nucleoplasm;perinuclear region of cytoplasm;RISC-loading complex",{"$nulls":3},2,2,2,"9.6","9.6","9.6","34.404",0,"4.2751",28702000,8,"0.302262","0.726476","-0.587371","-0.819585","sp|O75569|PRKRA_HUMAN;tr|F8WEG8|F8WEG8_HUMAN;tr|G5E9Q4|G5E9Q4_HUMAN;tr|C9JMM3|C9JMM3_HUMAN","sp|O75569|PRKRA_HUMAN;tr|F8WEG8|F8WEG8_HUMAN;tr|G5E9Q4|G5E9Q4_HUMAN;tr|C9JMM3|C9JMM3_HUMAN",353,"O75569","PRKRA_HUMAN","Interferon-inducible double-stranded RNA-dependent protein kinase activator A",null,"PRKRA"]
["19.0349","18.7009","19.2353","19.6764",{"$nulls":5},"cytosol;intercellular bridge;microtubule cytoskeleton",{"$nulls":3},2,2,2,"6.3","6.3","6.3","44.693",0,"24.504",103190000,11,"0.776084","0.337151","-0.587986","-2.12537","tr|C9JG97|C9JG97_HUMAN;sp|Q13685|AAMP_HUMAN;tr|C9JEH3|C9JEH3_HUMAN;tr|H7C0R2|H7C0R2_HUMAN;tr|C9JTS3|C9JTS3_HUMAN","tr|C9JG97|C9JG97_HUMAN;sp|Q13685|AAMP_HUMAN;tr|C9JEH3|C9JEH3_HUMAN;tr|H7C0R2|H7C0R2_HUMAN;tr|C9JTS3|C9JTS3_HUMAN",1585,"C9JG97","C9JG97_HUMAN",null,null,"AAMP"]
["19.7216","19.9084","20.628","20.1783",{"$nulls":3},"mRNA splice site selection;RNA splicing","DNA binding;mRNA binding;RNA binding","nuclear speck;nucleoplasm;nucleus;U1 snRNP;U2-type prespliceosome",{"$nulls":3},4,4,4,"13.7","13.7","13.7","51.466",0,"73.692",190030000,17,"0.863137","0.300429","-0.588126","-2.4153","sp|O95232|LC7L3_HUMAN;tr|J3KPP4|J3KPP4_HUMAN;tr|D6RDI2|D6RDI2_HUMAN;tr|E7EN55|E7EN55_HUMAN;tr|C9JL41|C9JL41_HUMAN;tr|H0YBV7|H0YBV7_HUMAN;tr|H0YAR4|H0YAR4_HUMAN","sp|O95232|LC7L3_HUMAN;tr|J3KPP4|J3KPP4_HUMAN;tr|D6RDI2|D6RDI2_HUMAN",420,"O95232","LC7L3_HUMAN","Luc7-like protein 3",null,"LUC7L3"]
["18.9954","18.6942","19.8193","19.049",{"$nulls":9},1,1,1,"24.2","24.2","24.2","7.6339","0.0066489","1.8345",19366000,1,"0.53734","0.490385","-0.589339","-1.42515","tr|C9JRS7|C9JRS7_HUMAN;tr|F8W8C3|F8W8C3_HUMAN;sp|Q96Q11|TRNT1_HUMAN","tr|C9JRS7|C9JRS7_HUMAN;tr|F8W8C3|F8W8C3_HUMAN;sp|Q96Q11|TRNT1_HUMAN",2336,"C9JRS7","C9JRS7_HUMAN",null,null,"TRNT1"]
["18.506","18.2947","19.339","18.6411",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;neutrophil degranulation","ATP binding","centrosome;cytoplasm;cytosol;dynactin complex;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;microtubule cytoskeleton;secretory granule lumen",{"$nulls":3},1,1,1,"6.1","6.1","6.1","42.293",0,"15.309",90851000,8,"0.606973","0.428092","-0.589714","-1.61741","sp|P42025|ACTY_HUMAN","sp|P42025|ACTY_HUMAN",988,"P42025","ACTY_HUMAN","Beta-centractin",null,"ACTR1B"]
["16.6033","17.4695","18.793","16.4594",{"$nulls":3},"cellular protein metabolic process;fucose metabolic process;glycoside catabolic process;neutrophil degranulation;post-translational protein modification;regulation of entry of bacterium into host cell;response to bacterium","alpha-L-fucosidase activity","azurophil granule lumen;endoplasmic reticulum lumen;extracellular exosome;extracellular region;extracellular space","Other glycan degradation",null,null,2,2,2,"6.9","6.9","6.9","54.066",0,"8.5239",47808000,14,"0.166046","0.85698","-0.589812","-0.4739","sp|Q9BTY2|FUCO2_HUMAN","sp|Q9BTY2|FUCO2_HUMAN",2452,"Q9BTY2","FUCO2_HUMAN","Plasma alpha-L-fucosidase",null,"FUCA2"]
["16.31","16.5702","17.4251","16.6361",{"$nulls":3},"negative regulation of retrograde protein transport, ER to cytosol;protein N-linked glycosylation via asparagine;regulation of tumor necrosis factor biosynthetic process;spermatid development;ubiquitin-dependent ERAD pathway","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding","cytoplasm;endoplasmic reticulum membrane;integral component of membrane","Parkinson disease;Protein processing in endoplasmic reticulum;Ubiquitin mediated proteolysis",null,null,1,1,1,"4.4","4.4","4.4","35.198","0.0027759","2.1812",15104000,1,"0.535998","0.492105","-0.590511","-1.42152","sp|Q9Y385|UB2J1_HUMAN","sp|Q9Y385|UB2J1_HUMAN",2976,"Q9Y385","UB2J1_HUMAN","Ubiquitin-conjugating enzyme E2 J1",null,"UBE2J1"]
["18.4687","18.0943","18.887","18.8595",{"$nulls":9},2,2,2,"20.5","20.5","20.5","13.334","0.001087","2.5131",60665000,3,"1.05752","0.304499","-0.591745","-3.15263","tr|H7C2R6|H7C2R6_HUMAN;tr|C9JX57|C9JX57_HUMAN;tr|D3DSE6|D3DSE6_HUMAN;tr|C9J818|C9J818_HUMAN;sp|P57076|CU059_HUMAN;tr|H7BZW1|H7BZW1_HUMAN;tr|F8VZ95|F8VZ95_HUMAN","tr|H7C2R6|H7C2R6_HUMAN;tr|C9JX57|C9JX57_HUMAN;tr|D3DSE6|D3DSE6_HUMAN;tr|C9J818|C9J818_HUMAN;sp|P57076|CU059_HUMAN;tr|H7BZW1|H7BZW1_HUMAN;tr|F8VZ95|F8VZ95_HUMAN",3107,"H7C2R6","H7C2R6_HUMAN",null,null,"C21orf59"]
["19.5297","19.3323","20.1003","19.9474",{"$nulls":3},"metabolic process","hydrolase activity;metal ion binding",{"$nulls":4},3,3,1,"13.4","13.4","5.4","34.596",0,"6.8653",79388000,13,"1.38071","0.334476","-0.592821","-4.74744","sp|Q96GK7|FAH2A_HUMAN","sp|Q96GK7|FAH2A_HUMAN",2281,"Q96GK7","FAH2A_HUMAN","Fumarylacetoacetate hydrolase domain-containing protein 2A",null,"FAHD2A"]
["19.694","19.7301","20.7801","19.8299",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein K63-linked deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of proteasomal protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to ethanol;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent protein catabolic process;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activator activity;Lys63-specific deubiquitinase activity;metal ion binding;metallopeptidase activity;proteasome binding;thiol-dependent ubiquitinyl hydrolase activity","cytosol;cytosolic proteasome complex;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, lid subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,3,3,3,"23.5","23.5","23.5","34.577",0,"20.493",168790000,15,"0.470312","0.53385","-0.592941","-1.24709","sp|O00487|PSDE_HUMAN;tr|C9JW37|C9JW37_HUMAN","sp|O00487|PSDE_HUMAN",146,"O00487","PSDE_HUMAN","26S proteasome non-ATPase regulatory subunit 14",null,"PSMD14"]
["17.8922","17.2993","19.1214","17.2569",{"$nulls":3},"7-methylguanosine mRNA capping;cellular response to leukemia inhibitory factor;transcription from RNA polymerase II promoter","mRNA (guanine-N7-)-methyltransferase activity;RNA binding","fibrillar center;mRNA cap binding complex;mRNA cap methyltransferase complex;nucleoplasm;nucleus;receptor complex","mRNA surveillance pathway",null,null,3,3,3,"9.2","9.2","9.2","54.843",0,"7.1787",60028000,9,"0.217674","0.802478","-0.593425","-0.60661","sp|O43148|MCES_HUMAN;tr|K7EP06|K7EP06_HUMAN;tr|K7EPP5|K7EPP5_HUMAN","sp|O43148|MCES_HUMAN;tr|K7EP06|K7EP06_HUMAN",228,"O43148","MCES_HUMAN","mRNA cap guanine-N7 methyltransferase",null,"RNMT"]
["20.2766","19.9725","20.9898","20.4477",{"$nulls":3},"autophagy;base-excision repair;cell aging;cell cycle arrest;cell differentiation;cell proliferation;cellular protein localization;cellular response to actinomycin D;cellular response to DNA damage stimulus;cellular response to drug;cellular response to gamma radiation;cellular response to glucose starvation;cellular response to heat;cellular response to hypoxia;cellular response to ionizing radiation;cellular response to reactive oxygen species;cellular response to UV;chromatin assembly;circadian behavior;determination of adult lifespan;DNA damage response, signal transduction by p53 class mediator;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;DNA strand renaturation;entrainment of circadian clock by photoperiod;ER overload response;intrinsic apoptotic signaling pathway;intrinsic apoptotic signaling pathway by p53 class mediator;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;mitotic G1 DNA damage checkpoint;mRNA transcription;multicellular organism development;negative regulation of apoptotic process;negative regulation of cell growth;negative regulation of cell proliferation;negative regulation of fibroblast proliferation;negative regulation of helicase activity;negative regulation of smooth muscle cell proliferation;negative regulation of telomerase activity;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;nucleotide-excision repair;oligodendrocyte apoptotic process;oxidative stress-induced premature senescence;positive regulation of apoptotic process;positive regulation of cell cycle arrest;positive regulation of execution phase of apoptosis;positive regulation of gene expression;positive regulation of histone deacetylation;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of leukocyte migration;positive regulation of neuron apoptotic process;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of pri-miRNA transcription from RNA polymerase II promoter;positive regulation of protein export from nucleus;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;positive regulation of protein oligomerization;positive regulation of reactive oxygen species metabolic process;positive regulation of release of cytochrome c from mitochondria;positive regulation of thymocyte apoptotic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;positive regulation of transcription, DNA-templated;proteasome-mediated ubiquitin-dependent protein catabolic process;protein complex assembly;protein deubiquitination;protein homotetramerization;protein localization;protein tetramerization;Ras protein signal transduction;regulation of apoptotic process;regulation of cell cycle G2/M phase transition;regulation of hydrogen peroxide-induced cell death;regulation of intracellular pH;regulation of mitochondrial membrane permeability;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;replicative senescence;response to amino acid;response to antibiotic;response to caffeine;response to cytokine;response to ethanol;response to gamma radiation;response to hyperoxia;response to metal ion;response to retinoic acid;response to UV-B;response to vitamin B3;response to X-ray;signal transduction by p53 class mediator;viral process;wound healing","ATP binding;chaperone binding;chromatin binding;copper ion binding;core promoter sequence-specific DNA binding;damaged DNA binding;disordered domain specific binding;DNA binding;DNA binding transcription factor activity;enzyme binding;histone acetyltransferase binding;histone deacetylase binding;identical protein binding;MDM2/MDM4 family protein binding;mRNA 3'-UTR binding;p53 binding;protease binding;protein C-terminus binding;protein heterodimerization activity;protein kinase binding;protein N-terminus binding;protein phosphatase 2A binding;protein phosphatase binding;protein self-association;receptor tyrosine kinase binding;RNA polymerase II regulatory region sequence-specific DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;RNA polymerase II transcription factor binding;transcription cofactor binding;transcription factor activity, core RNA polymerase binding;transcription factor binding;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;ubiquitin protein ligase binding;zinc ion binding","cytoplasm;cytosol;endoplasmic reticulum;intracellular;mitochondrial matrix;mitochondrion;nuclear chromatin;nuclear matrix;nucleolus;nucleoplasm;nucleus;PML body;protein complex;replication fork;transcription factor complex","Amyotrophic lateral sclerosis (ALS);Apoptosis;Basal cell carcinoma;Bladder cancer;Breast cancer;Cell cycle;Cellular senescence;Central carbon metabolism in cancer;Chronic myeloid leukemia;Colorectal cancer;Endocrine resistance;Endometrial cancer;Epstein-Barr virus infection;Ferroptosis;Fluid shear stress and atherosclerosis;Gastric cancer;Glioma;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Huntington disease;Kaposi sarcoma-associated herpesvirus infection;Longevity regulating pathway;MAPK signaling pathway;Measles;Melanoma;MicroRNAs in cancer;Mitophagy - animal;Neurotrophin signaling pathway;Non-small cell lung cancer;p53 signaling pathway;Pancreatic cancer;Pathways in cancer;PI3K-Akt signaling pathway;Platinum drug resistance;Prostate cancer;Proteoglycans in cancer;Small cell lung cancer;Sphingolipid signaling pathway;Thyroid cancer;Thyroid hormone signaling pathway;Transcriptional misregulation in cancer;Viral carcinogenesis;Wnt signaling pathway",null,null,5,5,5,13,13,13,"43.653",0,"7.0405",273250000,15,"0.707615","0.362893","-0.594173","-1.91177","sp|P04637|P53_HUMAN;tr|E7EQX7|E7EQX7_HUMAN;tr|J3KP33|J3KP33_HUMAN;tr|E7EMR6|E7EMR6_HUMAN;tr|A0A087WZU8|A0A087WZU8_HUMAN;tr|E9PCY9|E9PCY9_HUMAN;tr|S4R334|S4R334_HUMAN;tr|A0A087X1Q1|A0A087X1Q1_HUMAN;tr|E9PFT5|E9PFT5_HUMAN;tr|A0A087WXZ1|A0A087WXZ1_HUMAN;tr|A0A087WT22|A0A087WT22_HUMAN;tr|E7ESS1|E7ESS1_HUMAN","sp|P04637|P53_HUMAN;tr|E7EQX7|E7EQX7_HUMAN;tr|J3KP33|J3KP33_HUMAN;tr|E7EMR6|E7EMR6_HUMAN;tr|A0A087WZU8|A0A087WZU8_HUMAN",500,"P04637","P53_HUMAN","Cellular tumor antigen p53",null,"TP53"]
["24.1092","23.593","24.652","24.2394",{"$nulls":3},"actin cytoskeleton reorganization;adaptive immune response;alpha-beta T cell differentiation;arachidonic acid secretion;cell surface receptor signaling pathway;cellular response to glucocorticoid stimulus;cellular response to hydrogen peroxide;cellular response to vascular endothelial growth factor stimulus;DNA duplex unwinding;DNA rewinding;endocrine pancreas development;estrous cycle;gliogenesis;G-protein coupled receptor signaling pathway;G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;granulocyte chemotaxis;hepatocyte differentiation;inflammatory response;innate immune response;insulin secretion;keratinocyte differentiation;monocyte chemotaxis;myoblast migration involved in skeletal muscle regeneration;negative regulation of apoptotic process;negative regulation of exocytosis;negative regulation of interleukin-8 secretion;negative regulation of phospholipase A2 activity;negative regulation of T-helper 2 cell differentiation;neutrophil clearance;neutrophil homeostasis;peptide cross-linking;phagocytosis;positive regulation of cell migration involved in sprouting angiogenesis;positive regulation of G1/S transition of mitotic cell cycle;positive regulation of interleukin-2 production;positive regulation of neutrophil apoptotic process;positive regulation of prostaglandin biosynthetic process;positive regulation of T cell proliferation;positive regulation of T-helper 1 cell differentiation;positive regulation of vesicle fusion;positive regulation of wound healing;prolactin secretion;prostate gland development;regulation of cell shape;regulation of hormone secretion;regulation of inflammatory response;regulation of interleukin-1 production;regulation of leukocyte migration;response to drug;response to estradiol;response to interleukin-1;response to peptide hormone;response to X-ray;signal transduction","annealing helicase activity;cadherin binding involved in cell-cell adhesion;calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;double-stranded DNA-dependent ATPase activity;helicase activity;phospholipase A2 inhibitor activity;phospholipid binding;protein binding, bridging;protein homodimerization activity;receptor binding;single-stranded DNA binding;single-stranded RNA binding;structural molecule activity","apical plasma membrane;basolateral plasma membrane;cell surface;cell-cell adherens junction;cornified envelope;cytoplasm;cytoplasmic vesicle membrane;cytosol;early endosome membrane;endosome;extracellular exosome;extracellular region;extracellular space;extrinsic component of endosome membrane;extrinsic component of external side of plasma membrane;extrinsic component of membrane;focal adhesion;lateral plasma membrane;mast cell granule;mitochondrial membrane;motile cilium;nucleoplasm;nucleus;phagocytic cup;plasma membrane;protein complex;sarcolemma;vesicle",{"$nulls":3},16,16,16,"52.9","52.9","52.9","38.714",0,"168.49",5563200000,110,"0.670006","0.387287","-0.594547","-1.79924","sp|P04083|ANXA1_HUMAN;tr|Q5T3N1|Q5T3N1_HUMAN;tr|Q5T3N0|Q5T3N0_HUMAN","sp|P04083|ANXA1_HUMAN;tr|Q5T3N1|Q5T3N1_HUMAN",492,"P04083","ANXA1_HUMAN","Annexin A1",null,"ANXA1"]
["21.5221","20.8067","21.7805","21.7384",{"$nulls":3},"activation of innate immune response;circadian rhythm;DNA recombination;DNA repair;innate immune response;mRNA processing;mRNA splicing, via spliceosome;negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;negative regulation of transcription, DNA-templated;regulation of circadian rhythm;regulation of transcription, DNA-templated;RNA splicing;transcription, DNA-templated","chromatin binding;core promoter binding;identical protein binding;RNA binding;RNA polymerase II distal enhancer sequence-specific DNA binding;transcription regulatory region sequence-specific DNA binding","membrane;nuclear matrix;nuclear speck;nucleolus;nucleoplasm;nucleus;paraspeckles;RNA polymerase II transcription factor complex",{"$nulls":3},14,14,12,34,34,34,"54.231",0,"76.838",480870000,45,"0.622178","0.422361","-0.595025","-1.66054","sp|Q15233|NONO_HUMAN;tr|H7C367|H7C367_HUMAN;tr|C9IZL7|C9IZL7_HUMAN;tr|C9JYS8|C9JYS8_HUMAN","sp|Q15233|NONO_HUMAN;tr|H7C367|H7C367_HUMAN",1685,"Q15233","NONO_HUMAN","Non-POU domain-containing octamer-binding protein","onO protein","NONO"]
["19.7825","19.8272","20.6183","20.1817",{"$nulls":3},"cell division;DNA replication initiation","ATP binding;chromatin binding;DNA helicase activity;DNA replication origin binding","MCM complex;nucleoplasm",{"$nulls":3},9,9,9,"19.4","19.4","19.4","77.592",0,"22.382",439160000,27,"0.94575","0.29556","-0.595137","-2.71215","tr|B1AHB1|B1AHB1_HUMAN;sp|P33992|MCM5_HUMAN","tr|B1AHB1|B1AHB1_HUMAN;sp|P33992|MCM5_HUMAN",913,"B1AHB1","B1AHB1_HUMAN","DNA helicase {ECO:0000256|SAAS:SAAS00536514}"]
["18.3877","18.4032","19.3101","18.6717",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion","Ribosome",null,null,2,2,2,"13.6","13.6","13.6","23.64",0,"7.1829",51860000,14,"0.692104","0.373093","-0.595409","-1.86497","sp|Q9NWU5|RM22_HUMAN;tr|E7ESL0|E7ESL0_HUMAN;tr|A0A0C4DGX2|A0A0C4DGX2_HUMAN;tr|J3KQY1|J3KQY1_HUMAN","sp|Q9NWU5|RM22_HUMAN;tr|E7ESL0|E7ESL0_HUMAN;tr|A0A0C4DGX2|A0A0C4DGX2_HUMAN;tr|J3KQY1|J3KQY1_HUMAN",2728,"Q9NWU5","RM22_HUMAN","39S ribosomal protein L22, mitochondrial","22mt;RP-L22","MRPL22"]
["17.4349","16.5224","17.7745","17.3747",{"$nulls":3},"activation of phospholipase D activity;adenylate cyclase-activating G-protein coupled receptor signaling pathway;branching involved in blood vessel morphogenesis;cell differentiation;G-protein coupled receptor signaling pathway;in utero embryonic development;movement of cell or subcellular component;platelet activation;positive regulation of apoptotic process;positive regulation of cytosolic calcium ion concentration;regulation of cell migration;regulation of cell shape;regulation of small GTPase mediated signal transduction;Rho protein signal transduction;signal transduction","D5 dopamine receptor binding;G-protein beta/gamma-subunit complex binding;GTP binding;GTPase activity;guanyl-nucleotide exchange factor activity;metal ion binding;Rho guanyl-nucleotide exchange factor activity;signal transducer activity;type 1 angiotensin receptor binding","brush border membrane;cytosol;extracellular exosome;focal adhesion;heterotrimeric G-protein complex;melanosome;membrane;nucleus;plasma membrane","Apelin signaling pathway;cGMP-PKG signaling pathway;Human cytomegalovirus infection;Long-term depression;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;Phospholipase D signaling pathway;Platelet activation;Regulation of actin cytoskeleton;Sphingolipid signaling pathway;Vascular smooth muscle contraction",null,null,3,3,3,"11.4","11.4","11.4","44.049",0,"4.2039",34204000,5,"0.450779","0.55188","-0.59591","-1.19626","sp|Q14344|GNA13_HUMAN","sp|Q14344|GNA13_HUMAN",1620,"Q14344","GNA13_HUMAN","Guanine nucleotide-binding protein subunit alpha-13"," alpha-13;-protein subunit alpha-13","GNA13"]
["16.635","16.162","17.4903","16.5009",{"$nulls":3},"mitochondrial ATP synthesis coupled electron transport;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;response to oxidative stress","4 iron, 4 sulfur cluster binding;electron transfer activity;metal ion binding;NAD binding;NADH dehydrogenase (ubiquinone) activity;quinone binding;ubiquitin protein ligase binding","mitochondrial matrix;mitochondrial respiratory chain complex I;mitochondrion;nucleoplasm","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,1,1,1,"4.1","4.1","4.1","52.545",0,"3.8058",24256000,9,"0.409046","0.609946","-0.597095","-1.08896","sp|O75306|NDUS2_HUMAN","sp|O75306|NDUS2_HUMAN",330,"O75306","NDUS2_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial",null,"NDUFS2"]
["15.9708","15.5765","16.8103","15.9338",{"$nulls":9},2,2,2,"4.5","4.5","4.5","74.789",0,"6.6664",28075000,3,"0.469597","0.533815","-0.598365","-1.24522","tr|H0Y6I6|H0Y6I6_HUMAN;sp|Q96ME1|FXL18_HUMAN","tr|H0Y6I6|H0Y6I6_HUMAN;sp|Q96ME1|FXL18_HUMAN",2328,"H0Y6I6","H0Y6I6_HUMAN",null,null,"FBXL18"]
["16.6774","16.8962","17.3858","17.3852",{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},1,1,1,"2.7","2.7","2.7","53.119",0,"5.5307",42812000,9,"1.49768","0.320373","-0.598699","-5.47379","tr|A0A0D9SFL2|A0A0D9SFL2_HUMAN;tr|M0QYH2|M0QYH2_HUMAN;sp|Q96T60|PNKP_HUMAN","tr|A0A0D9SFL2|A0A0D9SFL2_HUMAN;tr|M0QYH2|M0QYH2_HUMAN;sp|Q96T60|PNKP_HUMAN",2363,"A0A0D9SFL2","A0A0D9SFL2_HUMAN",null,null,"PNKP"]
["18.2294","18.055","19.1806","18.3015",{"$nulls":3},"transcription, DNA-templated","DNA binding transcription factor activity;sequence-specific DNA binding","endoplasmic reticulum;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},3,3,3,"10.9","10.9","10.9","58.683",0,"4.1691",31342000,4,"0.504178","0.513051","-0.598837","-1.3363","tr|A0A0C4DG88|A0A0C4DG88_HUMAN;sp|P14859|PO2F1_HUMAN;tr|A0A0A0MT46|A0A0A0MT46_HUMAN;tr|H0YLC5|H0YLC5_HUMAN;tr|U3KQN1|U3KQN1_HUMAN;tr|U3KQ96|U3KQ96_HUMAN;tr|H0YNW1|H0YNW1_HUMAN;sp|Q9UKI9|PO2F3_HUMAN;sp|P09086|PO2F2_HUMAN;tr|H0YLL6|H0YLL6_HUMAN;tr|B5ME60|B5ME60_HUMAN;tr|H0YKT2|H0YKT2_HUMAN","tr|A0A0C4DG88|A0A0C4DG88_HUMAN;sp|P14859|PO2F1_HUMAN;tr|A0A0A0MT46|A0A0A0MT46_HUMAN",675,"A0A0C4DG88","A0A0C4DG88_HUMAN","POU domain protein {ECO:0000256|RuleBase:RU361194}",null,"POU2F1"]
["18.6308","18.9481","19.5741","19.2029",{"$nulls":3},"translation","structural constituent of ribosome","mitochondrion;ribosome",{"$nulls":3},2,2,2,"17.5","17.5","17.5","16.603",0,"5.0632",54074000,5,"0.874077","0.305172","-0.599038","-2.45333","tr|S4R3W9|S4R3W9_HUMAN;sp|P49406|RM19_HUMAN;tr|S4R455|S4R455_HUMAN;tr|A0A0A0MRF4|A0A0A0MRF4_HUMAN","tr|S4R3W9|S4R3W9_HUMAN;sp|P49406|RM19_HUMAN;tr|S4R455|S4R455_HUMAN;tr|A0A0A0MRF4|A0A0A0MRF4_HUMAN",1075,"S4R3W9","S4R3W9_HUMAN",null,null,"MRPL19"]
["22.1939","22.2832","23.0328","22.6443",{"$nulls":3},"apoptotic DNA fragmentation;astral microtubule organization;establishment of mitotic spindle localization;establishment of protein localization;intracellular transport of virus;mitotic chromosome movement towards spindle pole;mitotic metaphase plate congression;mitotic spindle assembly;modulation by virus of host process;neutrophil degranulation;NLS-bearing protein import into nucleus;protein import into nucleus;protein import into nucleus, translocation;Ran protein signal transduction;regulation of cholesterol biosynthetic process;ribosomal protein import into nucleus","enzyme binding;Hsp90 protein binding;nuclear localization sequence binding;protein domain specific binding;protein transporter activity;Ran GTPase binding;RNA binding;zinc ion binding","cytoplasm;cytosol;endoplasmic reticulum tubular network;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;host cell;membrane;nuclear envelope;nuclear membrane;nuclear periphery;nuclear pore;nucleoplasm;specific granule lumen","RNA transport",null,null,18,18,18,"31.1","31.1","31.1","97.169",0,"216.08",2801600000,117,"1.02266","0.297136","-0.600033","-3.01006","sp|Q14974|IMB1_HUMAN;tr|J3KTM9|J3KTM9_HUMAN;tr|J3QR48|J3QR48_HUMAN;tr|J3QKQ5|J3QKQ5_HUMAN;tr|J3QRG4|J3QRG4_HUMAN;tr|J3KS06|J3KS06_HUMAN","sp|Q14974|IMB1_HUMAN;tr|J3KTM9|J3KTM9_HUMAN",1650,"Q14974","IMB1_HUMAN","Importin subunit beta-1",null,"KPNB1"]
["19.0273","19.0678","19.75","19.5478",{"$nulls":3},"positive regulation of cytoskeleton organization;protein folding","protein binding involved in protein folding;unfolded protein binding","cytoplasm;cytosol;extracellular exosome;mitochondrion;nucleus;prefoldin complex",{"$nulls":3},2,2,2,"15.6","15.6","15.6","16.648","0.0037658","2.0538",68194000,7,"1.55046","0.327591","-0.601378","-5.8332","sp|Q9UHV9|PFD2_HUMAN","sp|Q9UHV9|PFD2_HUMAN",2840,"Q9UHV9","PFD2_HUMAN","Prefoldin subunit 2",null,"PFDN2"]
["18.5783","17.9906","19.7055","18.0664",{"$nulls":9},1,1,1,"36.7","36.7","36.7","6.3166","0.00040339","3.428",14509000,4,"0.251007","0.771744","-0.601507","-0.690908","tr|E9PS47|E9PS47_HUMAN;tr|E9PLE4|E9PLE4_HUMAN;sp|Q9BVG9|PTSS2_HUMAN","tr|E9PS47|E9PS47_HUMAN;tr|E9PLE4|E9PLE4_HUMAN;sp|Q9BVG9|PTSS2_HUMAN",2472,"E9PS47","E9PS47_HUMAN",null,null,"PTDSS2"]
["19.4503","18.2492","19.8347","19.0688",{"$nulls":3},"canonical glycolysis;cellular response to leukemia inhibitory factor;fructose 6-phosphate metabolic process","6-phosphofructokinase activity;ATP binding;cadherin binding;identical protein binding;metal ion binding;protein complex binding","cytoplasm;cytosol;extracellular exosome;extracellular matrix;membrane;nucleus","AMPK signaling pathway;Biosynthesis of amino acids;Carbon metabolism;Central carbon metabolism in cancer;Fructose and mannose metabolism;Galactose metabolism;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Pentose phosphate pathway;RNA degradation;Thyroid hormone signaling pathway",null,null,7,6,6,"12.6","10.2","10.2","85.595",0,"15.204",237730000,23,"0.312469","0.714209","-0.602018","-0.845173","sp|Q01813|PFKAP_HUMAN;tr|B1APP6|B1APP6_HUMAN;tr|H0Y3Y3|H0Y3Y3_HUMAN;tr|V9GY25|V9GY25_HUMAN;tr|B1APP8|B1APP8_HUMAN","sp|Q01813|PFKAP_HUMAN",1421,"Q01813","PFKAP_HUMAN","ATP-dependent 6-phosphofructokinase, platelet type {ECO:0000255|HAMAP-Rule:MF_03184}","FK-P;TP-PFK {ECO:0000255|HAMAP-Rule:MF_03184}","PFKP"]
["21.128","20.5146","21.8984","20.9484",{"$nulls":3},"chaperone-mediated protein folding;negative regulation of cellular respiration;negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;negative regulation of reactive oxygen species biosynthetic process;response to stress;translational attenuation","ATP binding;protein kinase binding;RNA binding;tumor necrosis factor receptor binding;unfolded protein binding","extracellular exosome;lipid droplet;membrane;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;nucleoplasm",{"$nulls":3},11,11,11,"21.2","21.2","21.2","80.109",0,"50.114",957810000,40,"0.399541","0.6216","-0.60205","-1.06473","sp|Q12931|TRAP1_HUMAN;tr|I3L0K7|I3L0K7_HUMAN;tr|I3L239|I3L239_HUMAN;tr|I3L2D5|I3L2D5_HUMAN","sp|Q12931|TRAP1_HUMAN;tr|I3L0K7|I3L0K7_HUMAN",1508,"Q12931","TRAP1_HUMAN","Heat shock protein 75 kDa, mitochondrial","SP 75","TRAP1"]
["16.6547","16.4365","17.6055","16.6921",{"$nulls":5},"endosome;membrane",{"$nulls":3},5,5,5,"4.7","4.7","4.7","161.85",0,"44.69",87586000,16,"0.484621","0.522484","-0.603214","-1.28461","sp|Q8N3D4|EH1L1_HUMAN;tr|E9PIH6|E9PIH6_HUMAN;tr|H0YDZ9|H0YDZ9_HUMAN","sp|Q8N3D4|EH1L1_HUMAN",2045,"Q8N3D4","EH1L1_HUMAN","EH domain-binding protein 1-like protein 1",null,"EHBP1L1"]
["16.5336","16.2746","17.5476","16.4674",{"$nulls":3},"cardiac muscle tissue development;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;nervous system development","2 iron, 2 sulfur cluster binding;electron transfer activity;metal ion binding;NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion;myelin sheath","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,1,1,1,"7.6","7.6","7.6","27.391",0,"3.7408",15456000,5,"0.408025","0.610374","-0.603395","-1.08636","sp|P19404|NDUV2_HUMAN;tr|E7EPT4|E7EPT4_HUMAN","sp|P19404|NDUV2_HUMAN;tr|E7EPT4|E7EPT4_HUMAN",732,"P19404","NDUV2_HUMAN","NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial",null,"NDUFV2"]
["15.942",1,1,"17.1493",{"$nulls":3},"activation of JUN kinase activity;activation of MAPK activity;cellular response to DNA damage stimulus;DNA repair;execution phase of apoptosis;mitotic G2 DNA damage checkpoint;nervous system development;positive regulation of JNK cascade;positive regulation of stress-activated MAPK cascade;protein autophosphorylation;protein phosphorylation;regulation of actin cytoskeleton organization;regulation of apoptotic process;regulation of cytoskeleton organization;regulation of microtubule cytoskeleton organization;regulation of mitotic cell cycle;sister chromatid cohesion","ATP binding;kinase activity;MAP kinase kinase kinase activity;protein kinase activity;protein serine/threonine kinase activator activity;protein serine/threonine kinase activity;transferase activity","cytoplasm;cytosol;extracellular exosome","MAPK signaling pathway",null,null,1,1,1,"1.1","1.1","1.1","116.07","0.0047716","2.0258",20257000,0,"0.0171728","0.977663","-0.603619","-0.0548708","sp|Q7L7X3|TAOK1_HUMAN","sp|Q7L7X3|TAOK1_HUMAN",1936,"Q7L7X3","TAOK1_HUMAN","Serine/threonine-protein kinase TAO1",null,"TAOK1"]
["19.8001","19.7391","20.4138","20.333",{"$nulls":3},"4-hydroxyproline metabolic process;cell redox homeostasis;extracellular matrix organization;I-kappaB phosphorylation;male gonad development;negative regulation of male germ cell proliferation;neutrophil degranulation;protein maturation by protein folding;reactive oxygen species metabolic process;spermatogenesis","protein homodimerization activity;thioredoxin peroxidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;mitochondrion;nucleus;secretory granule lumen;smooth endoplasmic reticulum",{"$nulls":3},6,3,3,24,"14.8","14.8","30.54",0,"5.9086",198670000,12,"2.15785","0.419299","-0.603796","-11.9303","sp|Q13162|PRDX4_HUMAN;tr|H7C3T4|H7C3T4_HUMAN;tr|A6NJJ0|A6NJJ0_HUMAN;tr|A6NG45|A6NG45_HUMAN","sp|Q13162|PRDX4_HUMAN;tr|H7C3T4|H7C3T4_HUMAN",1530,"Q13162","PRDX4_HUMAN","Peroxiredoxin-4",null,"PRDX4"]
["14.0794","13.9654","14.9485","14.3066",{"$nulls":3},"centriole replication;cerebral cortex development;mitotic spindle organization;neurogenesis;RNA splicing","RNA binding","catalytic step 2 spliceosome;centriole;centrosome;nucleus;precatalytic spliceosome;spindle pole;U5 snRNP",{"$nulls":3},2,2,2,"2.1","2.1","2.1","165.95",0,"7.4279",14684000,5,"0.689191","0.374289","-0.60512","-1.85624","sp|O43379|WDR62_HUMAN","sp|O43379|WDR62_HUMAN",243,"O43379","WDR62_HUMAN","WD repeat-containing protein 62",null,"WDR62"]
["17.6626","17.9143","18.5462","18.2415",{"$nulls":3},"determination of ventral identity;dorsal/ventral pattern formation;negative regulation of JNK cascade;negative regulation of JUN kinase activity;regulation of protein homodimerization activity","phosphatidylinositol binding;protein domain specific binding","cytoplasm;membrane",{"$nulls":3},2,2,2,"10.5","10.5","10.5","35.023",0,"16.005",40216000,12,"1.03587","0.3","-0.605352","-3.06353","sp|Q96BJ3|AIDA_HUMAN","sp|Q96BJ3|AIDA_HUMAN",2238,"Q96BJ3","AIDA_HUMAN","Axin interactor, dorsalization-associated protein",null,"AIDA"]
["17.511","17.5071","18.5348","17.6953",{"$nulls":3},"actin cytoskeleton organization;actin filament severing;multicellular organism development;regulation of transcription, DNA-templated;transcription, DNA-templated","actin binding;actin filament binding","brush border;cytosol;focal adhesion;microtubule organizing center;nucleoplasm",{"$nulls":3},6,6,6,6,6,6,"144.75",0,"51.042",197390000,26,"0.544156","0.485065","-0.60599","-1.44362","sp|Q13045|FLII_HUMAN;tr|J3KS54|J3KS54_HUMAN","sp|Q13045|FLII_HUMAN",1515,"Q13045","FLII_HUMAN","Protein flightless-1 homolog",null,"FLII"]
["14.3944","14.671","15.0628","15.2158",{"$nulls":4},"metal ion binding;RNA binding",{"$nulls":4},1,1,1,"0.9","0.9","0.9","164.2","0.00039557","3.296",14392000,4,"1.20977","0.32244","-0.606601","-3.8374","sp|Q9UKJ3|GPTC8_HUMAN","sp|Q9UKJ3|GPTC8_HUMAN",2871,"Q9UKJ3","GPTC8_HUMAN","G patch domain-containing protein 8",null,"GPATCH8"]
["16.3351","15.8389","17.5953","15.7955",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;response to hydrogen peroxide;response to hypoxia;response to organonitrogen compound","NADH dehydrogenase (ubiquinone) activity","integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I;neuron projection","Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,1,1,1,"3.2","3.2","3.2","67.026",0,"5.8184",12515000,5,"0.235513","0.789582","-0.608442","-0.651818","sp|P03915|NU5M_HUMAN","sp|P03915|NU5M_HUMAN",486,"P03915","NU5M_HUMAN","NADH-ubiquinone oxidoreductase chain 5",null,"MT-ND5"]
["15.7861","18.2794","16.8434","18.4394",{"$nulls":9},2,2,2,"10.5","10.5","10.5","27.468","0.0010642","2.3581",22203000,3,"0.142173","0.88314","-0.608598","-0.411167","tr|F5H0B0|F5H0B0_HUMAN;tr|H0YC42|H0YC42_HUMAN;tr|U3KQQ8|U3KQQ8_HUMAN;tr|E5RGC7|E5RGC7_HUMAN;tr|E5RFR7|E5RFR7_HUMAN;tr|H0YAT2|H0YAT2_HUMAN;tr|H0YC44|H0YC44_HUMAN;tr|H7C5V3|H7C5V3_HUMAN;sp|Q9Y2Q9|RT28_HUMAN;sp|P55327|TPD52_HUMAN","tr|F5H0B0|F5H0B0_HUMAN;tr|H0YC42|H0YC42_HUMAN;tr|U3KQQ8|U3KQQ8_HUMAN;tr|E5RGC7|E5RGC7_HUMAN;tr|E5RFR7|E5RFR7_HUMAN;tr|H0YAT2|H0YAT2_HUMAN;tr|H0YC44|H0YC44_HUMAN;tr|H7C5V3|H7C5V3_HUMAN;sp|Q9Y2Q9|RT28_HUMAN;sp|P55327|TPD52_HUMAN",3094,"F5H0B0"]
["16.3676","15.9611","17.1074","16.4387",{"$nulls":3},"enzyme active site formation via cysteine modification to L-cysteine persulfide;molybdopterin cofactor biosynthetic process;Mo-molybdopterin cofactor biosynthetic process;protein urmylation;tRNA thio-modification;tRNA wobble position uridine thiolation;tRNA wobble uridine modification","ATP binding;metal ion binding;molybdopterin-synthase adenylyltransferase activity;molybdopterin-synthase sulfurtransferase activity;nucleotidyltransferase activity;sulfurtransferase activity;thiosulfate sulfurtransferase activity;URM1 activating enzyme activity","cytosol","Sulfur relay system",null,null,1,1,1,"3.3","3.3","3.3","49.669",0,"4.8556",20485000,7,"0.584958","0.451797","-0.608697","-1.55572","sp|O95396|MOCS3_HUMAN","sp|O95396|MOCS3_HUMAN",432,"O95396","MOCS3_HUMAN","Adenylyltransferase and sulfurtransferase MOCS3 {ECO:0000255|HAMAP-Rule:MF_03049}",null,"MOCS3"]
["17.8934","17.4604","18.3366","18.2364",{"$nulls":4},"GTP binding;GTPase activity;translation elongation factor activity","intracellular",{"$nulls":3},5,5,5,"13.2","13.2","13.2","66.034",0,"7.3987",91619000,11,"0.954109","0.298719","-0.609571","-2.74347","tr|C9IZ01|C9IZ01_HUMAN;sp|Q96RP9|EFGM_HUMAN;tr|F8WAU4|F8WAU4_HUMAN","tr|C9IZ01|C9IZ01_HUMAN;sp|Q96RP9|EFGM_HUMAN;tr|F8WAU4|F8WAU4_HUMAN",2345,"C9IZ01","C9IZ01_HUMAN",null,null,"GFM1"]
["17.1162","16.825","17.3316","17.8296",{"$nulls":3},"COPII vesicle coating;endoplasmic reticulum organization;protein transport;substantia nigra development",null,"cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane",{"$nulls":3},7,7,7,"6.6","6.6","6.6","233.51",0,"8.0068",123920000,8,"0.772704","0.337793","-0.609964","-2.11454","sp|O15027|SC16A_HUMAN;tr|J3KNL6|J3KNL6_HUMAN;tr|A0A0C4DH09|A0A0C4DH09_HUMAN;tr|F1T0I1|F1T0I1_HUMAN;tr|X6RGP5|X6RGP5_HUMAN;tr|Q8N9G1|Q8N9G1_HUMAN","sp|O15027|SC16A_HUMAN;tr|J3KNL6|J3KNL6_HUMAN;tr|A0A0C4DH09|A0A0C4DH09_HUMAN;tr|F1T0I1|F1T0I1_HUMAN;tr|X6RGP5|X6RGP5_HUMAN",192,"O15027","SC16A_HUMAN","Protein transport protein Sec16A",null,"SEC16A"]
["20.0478","18.4877","20.9361","18.8196",{"$nulls":3},"autophagy;cell proliferation;cellular calcium ion homeostasis;cellular water homeostasis;epithelial cell differentiation;hemostasis;membrane fusion;negative regulation of gene expression;regulation of cell shape;response to calcium ion;response to organic cyclic compound;response to salt stress;social behavior","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;integrin binding;RNA binding","cytosol;endoplasmic reticulum membrane;extracellular exosome;membrane;nuclear envelope;nucleus;plasma membrane",{"$nulls":3},4,4,4,"10.9","10.9","10.9","52.739",0,"22.131",241770000,15,"0.162267","0.86301","-0.610065","-0.46404","sp|P20073|ANXA7_HUMAN","sp|P20073|ANXA7_HUMAN",738,"P20073","ANXA7_HUMAN","Annexin A7",null,"ANXA7"]
["23.4924","23.1455","23.9165","23.9415",{"$nulls":3},"translation","RNA binding;structural constituent of ribosome","small ribosomal subunit",{"$nulls":3},8,8,8,"33.5","33.5","33.5","22.391",0,147,1321600000,72,"1.13952","0.3132","-0.610078","-3.50821","tr|M0R0F0|M0R0F0_HUMAN;sp|P46782|RS5_HUMAN;tr|M0R0R2|M0R0R2_HUMAN;tr|M0QZN2|M0QZN2_HUMAN","tr|M0R0F0|M0R0F0_HUMAN;sp|P46782|RS5_HUMAN;tr|M0R0R2|M0R0R2_HUMAN;tr|M0QZN2|M0QZN2_HUMAN",1036,"M0R0F0","M0R0F0_HUMAN",null,null,"RPS5"]
["17.7527","17.9253","18.7719","18.1265",{"$nulls":3},"cell adhesion;cellular defense response;platelet degranulation;signal transduction","scavenger receptor activity","blood microparticle;extracellular exosome;extracellular matrix;extracellular region;extracellular space;membrane;platelet dense granule lumen;proteinaceous extracellular matrix",{"$nulls":3},3,3,3,"6.7","6.7","6.7","65.33",0,"20.08",72902000,16,"0.679246","0.379742","-0.61022","-1.82659","sp|Q08380|LG3BP_HUMAN;tr|K7EJY8|K7EJY8_HUMAN;tr|K7ESM3|K7ESM3_HUMAN;tr|K7EKQ5|K7EKQ5_HUMAN;tr|K7EP36|K7EP36_HUMAN","sp|Q08380|LG3BP_HUMAN",1474,"Q08380","LG3BP_HUMAN","Galectin-3-binding protein",null,"LGALS3BP"]
["17.8802","17.3859","18.491","17.9958",{"$nulls":9},5,5,5,"8.8","8.8","8.8","103.69",0,"32.122",84482000,11,"0.65146","0.39171","-0.610376","-1.7449","sp|Q7Z3E2|CC186_HUMAN;tr|H0Y7V5|H0Y7V5_HUMAN;tr|A0A0C4DFU7|A0A0C4DFU7_HUMAN","sp|Q7Z3E2|CC186_HUMAN;tr|H0Y7V5|H0Y7V5_HUMAN",1947,"Q7Z3E2","CC186_HUMAN","Coiled-coil domain-containing protein 186",null,"CCDC186"]
["20.1936","20.1668","20.921","20.6604",{"$nulls":4},"oxidoreductase activity","membrane;mitochondrion;peroxisome",{"$nulls":3},6,6,6,"15.3","15.3","15.3","45.394",0,"50.127",321360000,22,"1.36569","0.330448","-0.610477","-4.66064","sp|Q6YN16|HSDL2_HUMAN","sp|Q6YN16|HSDL2_HUMAN",1913,"Q6YN16","HSDL2_HUMAN","Hydroxysteroid dehydrogenase-like protein 2",null,"HSDL2"]
["23.65","22.8672","24.0172","23.7232",{"$nulls":3},"binding of sperm to zona pellucida;chaperone mediated protein folding independent of cofactor;chaperone-mediated protein complex assembly;neutrophil degranulation;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;scaRNA localization to Cajal body;toxin transport","ATP binding;protein binding involved in protein folding;ubiquitin protein ligase binding;unfolded protein binding","azurophil granule lumen;cell body;chaperonin-containing T-complex;cytosol;extracellular exosome;extracellular matrix;extracellular region;microtubule;myelin sheath;zona pellucida receptor complex",{"$nulls":3},20,20,20,"52.1","52.1","52.1","57.488",0,"323.31",4556200000,154,"0.551211","0.478482","-0.611577","-1.4628","sp|P78371|TCPB_HUMAN;tr|F5GWF6|F5GWF6_HUMAN;tr|F8VQ14|F8VQ14_HUMAN","sp|P78371|TCPB_HUMAN;tr|F5GWF6|F5GWF6_HUMAN;tr|F8VQ14|F8VQ14_HUMAN",1369,"P78371","TCPB_HUMAN","T-complex protein 1 subunit beta","CP-1-beta","CCT2"]
["16.613","16.4385","17.6359","16.6392",{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},3,3,3,4,4,4,"125.87",0,"5.846",37493000,12,"0.455802","0.547174","-0.611794","-1.20929","sp|O95104|SFR15_HUMAN","sp|O95104|SFR15_HUMAN",410,"O95104","SFR15_HUMAN","Splicing factor, arginine/serine-rich 15",null,"SCAF4"]
["21.1942","20.6295","22.0882","20.9616",{"$nulls":3},"positive regulation of ATPase activity;social behavior","heat shock protein binding","cytoplasm;cytosol;extracellular space;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},4,4,4,"26.5","26.5","26.5","29.909",0,"98.647",339620000,23,"0.36328","0.666114","-0.613021","-0.972877","sp|Q8WXX5|DNJC9_HUMAN","sp|Q8WXX5|DNJC9_HUMAN",2159,"Q8WXX5","DNJC9_HUMAN","DnaJ homolog subfamily C member 9","DJC9 {ECO:0000303|PubMed:17182002}","DNAJC9"]
["18.094","18.4852","19.4874","18.3185",{"$nulls":3},"nuclear membrane organization",null,"endoplasmic reticulum;Golgi apparatus;integral component of membrane;nuclear inner membrane",{"$nulls":3},5,5,5,"18.8","18.8","18.8","44.875",0,"10.488",83756000,13,"0.372121","0.653025","-0.613362","-0.995202","sp|Q9BTV4|TMM43_HUMAN","sp|Q9BTV4|TMM43_HUMAN",2450,"Q9BTV4","TMM43_HUMAN","Transmembrane protein 43",null,"TMEM43"]
["16.0795","15.2416","15.9832","16.5654",{"$nulls":3},"brain development;central nervous system development;embryonic camera-type eye development;G2/M transition of mitotic cell cycle;negative regulation of catalytic activity;negative regulation of protein binding;positive regulation of intermediate filament depolymerization;positive regulation of neural precursor cell proliferation;stem cell proliferation","intermediate filament binding;structural molecule activity","cytoplasm;extracellular matrix;intermediate filament;intermediate filament cytoskeleton",{"$nulls":3},7,7,7,"5.9","5.9","5.9","177.44",0,"12.506",72805000,8,"0.453409","0.550756","-0.61376","-1.20308","sp|P48681|NEST_HUMAN","sp|P48681|NEST_HUMAN",1059,"P48681","NEST_HUMAN","Nestin",null,"NES"]
["16.2763","16.0011","17.9262","15.579",{"$nulls":3},"cellular response to superoxide","metal ion binding;poly(ADP-ribose) glycohydrolase activity","mitochondrial matrix;nuclear body;nucleoplasm",{"$nulls":3},2,2,2,"8.3","8.3","8.3","38.946",0,"4.0223",10316000,2,"0.183648","0.832551","-0.613893","-0.519533","sp|Q9NX46|ARHL2_HUMAN","sp|Q9NX46|ARHL2_HUMAN",2735,"Q9NX46","ARHL2_HUMAN","Poly(ADP-ribose) glycohydrolase ARH3",null,"ADPRHL2"]
["19.5953","19.9989","20.6973","20.1253",{"$nulls":3},"animal organ morphogenesis;cell cycle arrest;cell proliferation;cellular iron ion homeostasis;Fc-epsilon receptor signaling pathway;G1/S transition of mitotic cell cycle;G2/M transition of mitotic cell cycle;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;negative regulation of G2/M transition of mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein monoubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;SCF complex assembly;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;viral process;Wnt signaling pathway","ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cullin-RING ubiquitin ligase complex;cytosol;nucleoplasm;Parkin-FBXW7-Cul1 ubiquitin ligase complex;SCF ubiquitin ligase complex","Cell cycle;Circadian rhythm;Hedgehog signaling pathway;Human immunodeficiency virus 1 infection;Oocyte meiosis;Pathways in cancer;Protein processing in endoplasmic reticulum;TGF-beta signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway",null,null,10,10,10,"17.3","17.3","17.3","89.677",0,"26.839",475090000,45,"0.654777","0.390917","-0.614165","-1.75456","sp|Q13616|CUL1_HUMAN;tr|A0A0C4DGX4|A0A0C4DGX4_HUMAN","sp|Q13616|CUL1_HUMAN;tr|A0A0C4DGX4|A0A0C4DGX4_HUMAN",1577,"Q13616","CUL1_HUMAN","Cullin-1","UL-1","CUL1"]
["16.934","16.8631","17.8531","17.1726",{"$nulls":9},1,1,1,"16.5","16.5","16.5","11.348","0.0011148","2.7536",7074700,1,"0.668793","0.387747","-0.614297","-1.79566","tr|G3V1T4|G3V1T4_HUMAN;sp|P57740|NU107_HUMAN","tr|G3V1T4|G3V1T4_HUMAN;sp|P57740|NU107_HUMAN",1229,"G3V1T4","G3V1T4_HUMAN"]
["20.2206","20.2243","21.2949","20.3787",{"$nulls":3},"cell separation after cytokinesis;endosomal transport;ESCRT III complex disassembly;establishment of protein localization;exit from mitosis;macroautophagy;membrane invagination;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of cell death;negative regulation of centriole elongation;nuclear envelope reassembly;nucleus organization;positive regulation of exosomal secretion;positive regulation of viral release from host cell;protein heterooligomerization;protein homooligomerization;protein polymerization;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;regulation of viral process;vacuolar transport;viral budding via host ESCRT complex;viral life cycle","phosphatidylcholine binding;protein domain specific binding","cytosol;ESCRT III complex;extracellular exosome;late endosome membrane;membrane;membrane coat;nuclear envelope","Endocytosis;Necroptosis",null,null,2,2,2,"12.2","12.2","12.2","25.104",0,"24.326",146860000,7,"0.505936","0.514637","-0.614326","-1.34097","sp|O43633|CHM2A_HUMAN;tr|M0R1T5|M0R1T5_HUMAN;tr|M0R1L7|M0R1L7_HUMAN","sp|O43633|CHM2A_HUMAN;tr|M0R1T5|M0R1T5_HUMAN;tr|M0R1L7|M0R1L7_HUMAN",254,"O43633","CHM2A_HUMAN","Charged multivesicular body protein 2a",null,"CHMP2A"]
["15.5218","15.1773","16.3456","15.5823",{"$nulls":4},"protein-cysteine S-palmitoyltransferase activity","integral component of membrane",{"$nulls":3},1,1,1,"6.5","6.5","6.5","33.743",0,"3.6866",10365000,4,"0.552827","0.475375","-0.614382","-1.46721","tr|B4DRN8|B4DRN8_HUMAN;sp|Q5W0Z9|ZDH20_HUMAN","tr|B4DRN8|B4DRN8_HUMAN;sp|Q5W0Z9|ZDH20_HUMAN",1850,"B4DRN8","B4DRN8_HUMAN","Palmitoyltransferase {ECO:0000256|RuleBase:RU079119}",null,"ZDHHC20"]
["15.3197","13.9552","16.0546","14.4533",{"$nulls":3},"aging;brain development;calcium ion export across plasma membrane;cellular response to corticosterone stimulus;cellular response to vitamin D;ion transmembrane transport;neural retina development;regulation of cardiac conduction;regulation of cytosolic calcium ion concentration;response to cold;transport","ATP binding;calcium ion transmembrane transporter activity;calcium-transporting ATPase activity;calmodulin binding;metal ion binding;PDZ domain binding","apical plasma membrane;basolateral plasma membrane;cytoplasmic side of plasma membrane;dendritic spine membrane;extracellular exosome;integral component of plasma membrane;intracellular membrane-bounded organelle;membrane;membrane raft;neuronal cell body membrane;nucleus;plasma membrane","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Calcium signaling pathway;cAMP signaling pathway;cGMP-PKG signaling pathway;Endocrine and other factor-regulated calcium reabsorption;Mineral absorption;Pancreatic secretion;Salivary secretion",null,null,3,3,3,4,4,4,"138.75",0,"10.098",16797000,4,"0.209591","0.814246","-0.61648","-0.58604","sp|P20020|AT2B1_HUMAN;tr|E7ERY9|E7ERY9_HUMAN;sp|Q16720|AT2B3_HUMAN;sp|P23634|AT2B4_HUMAN;tr|H0Y7S3|H0Y7S3_HUMAN;sp|Q01814|AT2B2_HUMAN","sp|P20020|AT2B1_HUMAN;tr|E7ERY9|E7ERY9_HUMAN;sp|Q16720|AT2B3_HUMAN;sp|P23634|AT2B4_HUMAN",736,"P20020","AT2B1_HUMAN","Plasma membrane calcium-transporting ATPase 1","MCA1","ATP2B1"]
["23.1553","23.2859","24.1494","23.5256",{"$nulls":3},"defense response to virus;innate immune response;IRES-dependent viral translational initiation;mRNA metabolic process;mRNA splicing, via spliceosome;negative regulation of defense response to virus;negative regulation of type I interferon production;proteasome-mediated ubiquitin-dependent protein catabolic process;RNA metabolic process;viral RNA genome replication","DNA binding;enzyme binding;RNA binding;ubiquitin protein ligase binding","cytoplasm;cytosol;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus","Ferroptosis",null,null,9,5,1,"33.4","20.5","3.8","38.58",0,"61.52",2438000000,59,"0.715595","0.360017","-0.616924","-1.93607","sp|Q15366|PCBP2_HUMAN;tr|H3BSS4|H3BSS4_HUMAN","sp|Q15366|PCBP2_HUMAN",1695,"Q15366","PCBP2_HUMAN","Poly(rC)-binding protein 2",null,"PCBP2"]
["22.1985","21.1347","22.7636","21.8035",{"$nulls":3},"cell cycle phase transition;cell proliferation;cellular protein modification process;cellular response to glucocorticoid stimulus;cellular response to steroid hormone stimulus;positive regulation of protein targeting to mitochondrion;positive regulation of protein ubiquitination;positive regulation of ubiquitin-protein transferase activity;protein K11-linked ubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated;ubiquitin-dependent protein catabolic process","ATP binding;enzyme binding;RNA binding;transcription coactivator activity;ubiquitin conjugating enzyme activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activator activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;ubiquitin ligase complex","Parkinson disease;Ubiquitin mediated proteolysis",null,null,5,5,5,"51.9","51.9","51.9","17.861",0,"34.645",328120000,28,"0.318774","0.712141","-0.616929","-0.860985","sp|P68036|UB2L3_HUMAN;tr|A0A0B4J2G9|A0A0B4J2G9_HUMAN","sp|P68036|UB2L3_HUMAN;tr|A0A0B4J2G9|A0A0B4J2G9_HUMAN",1356,"P68036","UB2L3_HUMAN","Ubiquitin-conjugating enzyme E2 L3",null,"UBE2L3"]
["19.9169","19.7539","20.6355","20.2693",{"$nulls":3},"DNA deamination;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;isotype switching;nuclear mRNA surveillance;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';polyadenylation-dependent snoRNA 3'-end processing;positive regulation of isotype switching;regulation of mRNA stability;rRNA 3'-end processing;rRNA catabolic process;rRNA processing;U4 snRNA 3'-end processing","RNA binding","cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);nuclear exosome (RNase complex);nucleolus;nucleoplasm","RNA degradation",null,null,2,2,2,"11.4","11.4","11.4","28.235",0,"6.4894",108300000,7,"1.03974","0.299336","-0.617043","-3.0793","sp|Q5RKV6|EXOS6_HUMAN","sp|Q5RKV6|EXOS6_HUMAN",1822,"Q5RKV6","EXOS6_HUMAN","Exosome complex component MTR3",null,"EXOSC6"]
["20.139","19.1858","20.6387","19.9204",{"$nulls":3},"calcium ion import into sarcoplasmic reticulum;calcium ion transmembrane transport;calcium ion transport from cytosol to endoplasmic reticulum;cardiac muscle hypertrophy in response to stress;cell adhesion;cellular calcium ion homeostasis;cellular response to oxidative stress;endoplasmic reticulum calcium ion homeostasis;epidermis development;ER-nucleus signaling pathway;ion transmembrane transport;negative regulation of heart contraction;organelle organization;positive regulation of endoplasmic reticulum calcium ion concentration;positive regulation of heart rate;regulation of calcium ion-dependent exocytosis of neurotransmitter;regulation of cardiac conduction;regulation of cardiac muscle cell action potential involved in regulation of contraction;regulation of cardiac muscle cell membrane potential;regulation of cardiac muscle contraction by calcium ion signaling;regulation of the force of heart contraction;relaxation of cardiac muscle;response to endoplasmic reticulum stress;sarcoplasmic reticulum calcium ion transport;transition between fast and slow fiber;T-tubule organization","ATP binding;calcium ion binding;calcium-transporting ATPase activity;calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential;enzyme binding;lutropin-choriogonadotropic hormone receptor binding;protein C-terminus binding;S100 protein binding","calcium ion-transporting ATPase complex;endoplasmic reticulum;endoplasmic reticulum membrane;extrinsic component of cytoplasmic side of plasma membrane;integral component of plasma membrane;longitudinal sarcoplasmic reticulum;membrane;nucleoplasm;perinuclear region of cytoplasm;platelet dense tubular network membrane;protein complex;ribbon synapse;sarcoplasmic reticulum;sarcoplasmic reticulum membrane;vesicle membrane","Adrenergic signaling in cardiomyocytes;Alzheimer disease;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Calcium signaling pathway;cAMP signaling pathway;Cardiac muscle contraction;cGMP-PKG signaling pathway;Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM);Pancreatic secretion;Thyroid hormone signaling pathway",null,null,9,9,9,"10.2","10.2","10.2","114.76",0,"27.936",531270000,38,"0.387548","0.633369","-0.617192","-1.03426","sp|P16615|AT2A2_HUMAN;tr|H7C5W9|H7C5W9_HUMAN;sp|Q93084|AT2A3_HUMAN;sp|O14983|AT2A1_HUMAN;tr|H3BVB2|H3BVB2_HUMAN","sp|P16615|AT2A2_HUMAN;tr|H7C5W9|H7C5W9_HUMAN",699,"P16615","AT2A2_HUMAN","Sarcoplasmic/endoplasmic reticulum calcium ATPase 2","ERCA2;R Ca(2+)-ATPase 2","ATP2A2"]
["16.5338","16.2208","17.8398","16.152",{"$nulls":3},"tRNA export from nucleus;tRNA re-export from nucleus","Ran GTPase binding;tRNA binding","cytoplasm;cytosol;nuclear matrix;nucleoplasm","RNA transport",null,null,3,3,3,"4.3","4.3","4.3","109.96",0,"6.7639",51599000,7,"0.262862","0.759116","-0.618612","-0.720735","sp|O43592|XPOT_HUMAN;tr|F5GZM3|F5GZM3_HUMAN;tr|F8WDU6|F8WDU6_HUMAN","sp|O43592|XPOT_HUMAN",251,"O43592","XPOT_HUMAN","Exportin-T",null,"XPOT"]
["13.9196",1,"15.1577",1,{"$nulls":3},"GPI anchor biosynthetic process","mannose-ethanolamine phosphotransferase activity","endoplasmic reticulum membrane;integral component of membrane;membrane","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways",null,null,1,1,1,1,1,1,"118.7","0.0010638","2.3579",8718400,3,"0.0202834","0.974541","-0.619067","-0.0645985","sp|Q8TEQ8|PIGO_HUMAN","sp|Q8TEQ8|PIGO_HUMAN",2128,"Q8TEQ8","PIGO_HUMAN","GPI ethanolamine phosphate transferase 3",null,"PIGO"]
[1,"17.4441",1,"18.6827",{"$nulls":9},1,1,1,"6.2","6.2","6.2","21.485","0.0050488","1.922",20392000,1,"0.0160335","0.978053","-0.619282","-0.0512923","tr|H0YFT9|H0YFT9_HUMAN;tr|G3V1N5|G3V1N5_HUMAN;tr|B4E3L3|B4E3L3_HUMAN;sp|Q96RU2|UBP28_HUMAN","tr|H0YFT9|H0YFT9_HUMAN;tr|G3V1N5|G3V1N5_HUMAN;tr|B4E3L3|B4E3L3_HUMAN;sp|Q96RU2|UBP28_HUMAN",2349,"H0YFT9","H0YFT9_HUMAN",null,null,"USP28"]
["21.0193","21.2051","21.9467","21.5185",{"$nulls":5},"cytosol",{"$nulls":3},3,3,3,"22.8","22.8","22.8","22.649",0,"48.601",226190000,18,"0.93125","0.296163","-0.620405","-2.65839","tr|H0YAT1|H0YAT1_HUMAN;sp|Q9H788|SH24A_HUMAN","tr|H0YAT1|H0YAT1_HUMAN;sp|Q9H788|SH24A_HUMAN",2609,"H0YAT1","H0YAT1_HUMAN",null,null,"SH2D4A"]
["23.5029","23.1619","24.2051","23.7017",{"$nulls":3},"translation","RNA binding;structural constituent of ribosome","cytosol;endoplasmic reticulum;small ribosomal subunit",{"$nulls":3},10,10,10,"47.6","47.6","47.6","25.371",0,"51.933",2626500000,64,"0.749998","0.339565","-0.620959","-2.04259","tr|E9PL09|E9PL09_HUMAN;sp|P23396|RS3_HUMAN;tr|E9PPU1|E9PPU1_HUMAN;tr|H0YEU2|H0YEU2_HUMAN;tr|E9PQ96|E9PQ96_HUMAN;tr|E9PJH4|E9PJH4_HUMAN;tr|F2Z2S8|F2Z2S8_HUMAN;tr|H0YF32|H0YF32_HUMAN;tr|E9PK82|E9PK82_HUMAN;tr|H0YCJ7|H0YCJ7_HUMAN;tr|E9PSF4|E9PSF4_HUMAN;tr|H0YES8|H0YES8_HUMAN;tr|E9PQX2|E9PQX2_HUMAN","tr|E9PL09|E9PL09_HUMAN;sp|P23396|RS3_HUMAN;tr|E9PPU1|E9PPU1_HUMAN;tr|H0YEU2|H0YEU2_HUMAN;tr|E9PQ96|E9PQ96_HUMAN;tr|E9PJH4|E9PJH4_HUMAN;tr|F2Z2S8|F2Z2S8_HUMAN;tr|H0YF32|H0YF32_HUMAN;tr|E9PK82|E9PK82_HUMAN;tr|H0YCJ7|H0YCJ7_HUMAN",778,"E9PL09","E9PL09_HUMAN",null,null,"RPS3"]
["19.622","19.3633","20.1796","20.0477",{"$nulls":3},"histone acetylation;regulation of growth;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated",null,"NuA4 histone acetyltransferase complex;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"13.7","13.7","13.7","22.417",0,"45.951",75479000,10,"1.29631","0.332416","-0.621007","-4.27745","sp|Q9NV56|MRGBP_HUMAN","sp|Q9NV56|MRGBP_HUMAN",2716,"Q9NV56","MRGBP_HUMAN","MRG/MORF4L-binding protein",null,"MRGBP"]
["19.4233","19.5685","20.1421","20.0927",{"$nulls":3},"formation of translation preinitiation complex","translation initiation factor activity","eukaryotic 43S preinitiation complex;eukaryotic 48S preinitiation complex;eukaryotic translation initiation factor 3 complex",{"$nulls":3},2,2,2,"5.2","5.2","5.2","39.589",0,"3.8053",194890000,6,"1.82737","0.386647","-0.62149","-8.10582","tr|A0A087WZK9|A0A087WZK9_HUMAN;sp|O15372|EIF3H_HUMAN;tr|B3KS98|B3KS98_HUMAN;tr|E5RGU4|E5RGU4_HUMAN;tr|E5RJT0|E5RJT0_HUMAN","tr|A0A087WZK9|A0A087WZK9_HUMAN;sp|O15372|EIF3H_HUMAN;tr|B3KS98|B3KS98_HUMAN;tr|E5RGU4|E5RGU4_HUMAN;tr|E5RJT0|E5RJT0_HUMAN",218,"A0A087WZK9","A0A087WZK9_HUMAN","Eukaryotic translation initiation factor 3 subunit H {ECO:0000256|HAMAP-Rule:MF_03007}","IF3h {ECO:0000256|HAMAP-Rule:MF_03007}"]
["17.1142","16.7934","17.4938","17.6575",{"$nulls":3},"angiogenesis;signal transduction","receptor tyrosine kinase binding",{"$nulls":4},3,3,3,"18.5","18.5","18.5","32.507",0,"22.348",30926000,8,"1.1272","0.310051","-0.621888","-3.45287","tr|H0Y539|H0Y539_HUMAN;tr|X6R6D0|X6R6D0_HUMAN;sp|P29353|SHC1_HUMAN;tr|Q5T188|Q5T188_HUMAN","tr|H0Y539|H0Y539_HUMAN;tr|X6R6D0|X6R6D0_HUMAN;sp|P29353|SHC1_HUMAN",847,"H0Y539","H0Y539_HUMAN",null,null,"SHC1"]
["19.4729","17.112","20.2928","17.5366",{"$nulls":4},"serine-type endopeptidase activity",{"$nulls":4},3,3,3,"23.1","23.1","23.1","16.991",0,"4.7882",36105000,5,"0.1167","0.904727","-0.622215","-0.342897","tr|M0QYV5|M0QYV5_HUMAN;tr|M0R208|M0R208_HUMAN;sp|Q16740|CLPP_HUMAN","tr|M0QYV5|M0QYV5_HUMAN;tr|M0R208|M0R208_HUMAN;sp|Q16740|CLPP_HUMAN",3113,"M0QYV5","M0QYV5_HUMAN","ATP-dependent Clp protease proteolytic subunit {ECO:0000256|RuleBase:RU003567}",null,"CLPP"]
["19.8598","19.1993","20.0482","20.2565",{"$nulls":3},"cellular respiration;mitochondrial respiratory chain complex I assembly;negative regulation of insulin secretion involved in cellular response to glucose stimulus;reactive oxygen species metabolic process;respiratory electron transport chain","electron transfer activity;NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrion","Thermogenesis",null,null,3,3,3,"21.9","21.9","21.9","19.856",0,"23.886",75698000,14,"0.669779","0.386495","-0.622813","-1.79857","sp|Q8N183|MIMIT_HUMAN;tr|D6RA56|D6RA56_HUMAN","sp|Q8N183|MIMIT_HUMAN",2034,"Q8N183","NDUF2_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2",null,"NDUFAF2"]
["14.3214",1,"15.5691",1,{"$nulls":5},"intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},1,1,1,"4.6","4.6","4.6","69.548","0.002773","2.1741",7075300,3,"0.0198355","0.974714","-0.623839","-0.0632014","tr|H0Y517|H0Y517_HUMAN;tr|H7C1U3|H7C1U3_HUMAN;sp|Q5T0F9|C2D1B_HUMAN","tr|H0Y517|H0Y517_HUMAN;tr|H7C1U3|H7C1U3_HUMAN;sp|Q5T0F9|C2D1B_HUMAN",1826,"H0Y517","H0Y517_HUMAN",null,null,"CC2D1B"]
["18.5297","18.9488","19.8705","18.8571",{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},2,2,2,"7.7","7.7","7.7","36.43",0,"48.65",96668000,10,"0.428601","0.584396","-0.624551","-1.13904","tr|Q5JRC6|Q5JRC6_HUMAN;sp|Q8IWS0|PHF6_HUMAN;tr|A0A0D9SGE8|A0A0D9SGE8_HUMAN","tr|Q5JRC6|Q5JRC6_HUMAN;sp|Q8IWS0|PHF6_HUMAN;tr|A0A0D9SGE8|A0A0D9SGE8_HUMAN",2015,"Q5JRC6","Q5JRC6_HUMAN"]
["23.3873","23.2653","24.1283","23.7737",{"$nulls":3},"epithelial cell differentiation;platelet degranulation","cadherin binding","cytosol;extracellular exosome;extracellular region;vesicle",{"$nulls":3},9,9,9,"55.8","55.8","55.8","22.391",0,"116.42",1662400000,56,"1.09981","0.30931","-0.624698","-3.33233","sp|P37802|TAGL2_HUMAN;tr|X6RJP6|X6RJP6_HUMAN;tr|C9J5W6|C9J5W6_HUMAN;sp|Q9UI15|TAGL3_HUMAN","sp|P37802|TAGL2_HUMAN;tr|X6RJP6|X6RJP6_HUMAN",954,"P37802","TAGL2_HUMAN","Transgelin-2",null,"TAGLN2"]
["16.2377","16.2481","17.0764","16.659",{"$nulls":3},"nucleotide-excision repair;transcription, DNA-templated",null,"core TFIIH complex",{"$nulls":3},1,1,1,"16.6","16.6","16.6","20.404","0.0007533","2.8427",10299000,3,"1.01834","0.297043","-0.624792","-2.99275","tr|E9PI26|E9PI26_HUMAN;sp|P32780|TF2H1_HUMAN","tr|E9PI26|E9PI26_HUMAN;sp|P32780|TF2H1_HUMAN",905,"E9PI26","E9PI26_HUMAN",null,null,"GTF2H1"]
["20.768","20.5519","21.8229","20.7466",{"$nulls":3},"cell redox homeostasis;cellular response to oxidative stress;cellular response to reactive oxygen species;hydrogen peroxide catabolic process;inflammatory response;NADPH oxidation;negative regulation of apoptotic process;negative regulation of oxidoreductase activity;negative regulation of transcription from RNA polymerase III promoter;positive regulation of collagen biosynthetic process;reactive nitrogen species metabolic process;regulation of apoptosis involved in tissue homeostasis;response to oxidative stress","antioxidant activity;cysteine-type endopeptidase inhibitor activity involved in apoptotic process;peroxidase activity;peroxiredoxin activity;peroxynitrite reductase activity;protein dimerization activity;receptor binding;RNA polymerase III regulatory region DNA binding;thioredoxin peroxidase activity","cytoplasm;cytoplasmic vesicle;cytosol;extracellular exosome;extracellular space;intracellular membrane-bounded organelle;mitochondrial matrix;mitochondrion;nucleus;perinuclear region of cytoplasm;peroxisomal matrix;peroxisome","Peroxisome",null,null,6,6,6,35,35,35,"22.086",0,"30.449",282990000,33,"0.428306","0.58394","-0.624834","-1.13828","sp|P30044|PRDX5_HUMAN","sp|P30044|PRDX5_HUMAN",858,"P30044","PRDX5_HUMAN","Peroxiredoxin-5, mitochondrial",null,"PRDX5"]
["15.3592","15.3157","15.7652","16.1615",{"$nulls":3},"cell differentiation;cellular response to granulocyte macrophage colony-stimulating factor stimulus;negative regulation of cell proliferation;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","DEAD/H-box RNA helicase binding;RNA polymerase II regulatory region sequence-specific DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","nuclear chromatin;nucleus;RNA polymerase II transcription repressor complex",{"$nulls":3},1,1,1,"3.5","3.5","3.5","57.001","0.00076894","3.007",18599000,6,"1.0544","0.30576","-0.625931","-3.13969","sp|P41162|ETV3_HUMAN","sp|P41162|ETV3_HUMAN",980,"P41162","ETV3_HUMAN","ETS translocation variant 3",null,"ETV3"]
["17.1673","17.2952","17.6997","18.0147",{"$nulls":3},"negative regulation of proteolysis;protein folding;regulation of protein secretion;regulation of translation","ATPase activator activity;chaperone binding;DNA binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;nuclear membrane;plasma membrane","Protein processing in endoplasmic reticulum",null,null,2,2,2,"4.5","4.5","4.5","63.882",0,"27.271",53694000,13,"1.17748","0.31878","-0.625979","-3.68309","sp|Q96KC8|DNJC1_HUMAN","sp|Q96KC8|DNJC1_HUMAN",2318,"Q96KC8","DNJC1_HUMAN","DnaJ homolog subfamily C member 1",null,"DNAJC1"]
["17.7235","17.9391","19.7357","17.18",{"$nulls":9},1,1,1,"15.6","15.6","15.6","11.814",0,"3.829",21463000,7,"0.171691","0.849932","-0.626556","-0.488588","tr|H3BQQ6|H3BQQ6_HUMAN;tr|H3BTI2|H3BTI2_HUMAN;tr|H3BTP8|H3BTP8_HUMAN;tr|H3BSY6|H3BSY6_HUMAN;tr|H3BP64|H3BP64_HUMAN;tr|H3BUL4|H3BUL4_HUMAN;tr|H3BMX9|H3BMX9_HUMAN;tr|H3BU93|H3BU93_HUMAN;sp|Q9GZU8|F192A_HUMAN","tr|H3BQQ6|H3BQQ6_HUMAN;tr|H3BTI2|H3BTI2_HUMAN;tr|H3BTP8|H3BTP8_HUMAN;tr|H3BSY6|H3BSY6_HUMAN;tr|H3BP64|H3BP64_HUMAN;tr|H3BUL4|H3BUL4_HUMAN;tr|H3BMX9|H3BMX9_HUMAN;tr|H3BU93|H3BU93_HUMAN;sp|Q9GZU8|F192A_HUMAN",2545,"H3BQQ6","H3BQQ6_HUMAN",null,null,"FAM192A"]
["19.5043","19.5097","20.0863","20.1818",{"$nulls":3},"cell differentiation;multicellular organism development;regulation of T cell differentiation in thymus",null,"external side of plasma membrane;integral component of plasma membrane;membrane",{"$nulls":3},10,10,10,"17.5","17.5","17.5","76.096",0,"217.07",320500000,27,"2.23879","0.445867","-0.627037","-13.1071","sp|O96005|CLPT1_HUMAN;tr|K7EQQ1|K7EQQ1_HUMAN","sp|O96005|CLPT1_HUMAN;tr|K7EQQ1|K7EQQ1_HUMAN",459,"O96005","CLPT1_HUMAN","Cleft lip and palate transmembrane protein 1",null,"CLPTM1"]
["22.2002","22.3196","23.0737","22.7002",{"$nulls":3},"cytokine secretion;interleukin-1 alpha secretion;mast cell degranulation;positive regulation of cell proliferation;positive regulation of I-kappaB kinase/NF-kappaB signaling;regulation of cell shape;response to copper ion;response to electrical stimulus","calcium ion binding;copper ion binding;fibroblast growth factor binding;lipid binding;protein homodimerization activity;RAGE receptor binding;zinc ion binding","cytoplasm;cytosol;extracellular exosome;extracellular region;extracellular space;mast cell granule;nucleolus;nucleus;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},3,3,3,"31.6","31.6","31.6","11.471",0,"4.2825",323040000,9,"1.06853","0.303607","-0.627039","-3.1987","sp|Q99584|S10AD_HUMAN","sp|Q99584|S10AD_HUMAN",2384,"Q99584","S10AD_HUMAN","Protein S100-A13",null,"S100A13"]
["23.1924","23.277","24.0051","23.72",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;cellular hyperosmotic response;cellular response to tumor necrosis factor;fertilization;in utero embryonic development;male gonad development;negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;negative regulation of necroptotic process;negative regulation of skeletal muscle tissue development;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cytoplasmic translation;positive regulation of organ growth;response to cold;spermatogenesis;transcription, DNA-templated","DNA binding transcription factor activity;double-stranded DNA binding;mRNA 3'-UTR binding;Rho GTPase binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;single-stranded DNA binding;transcription corepressor activity;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","bicellular tight junction;cytoplasm;cytosol;nucleus;perinuclear region of cytoplasm;polysome","Tight junction",null,null,13,10,10,"57.8","48.1","48.1","40.089",0,"296.7",1570400000,67,"1.28604","0.327975","-0.627918","-4.22312","sp|P16989|YBOX3_HUMAN;tr|A0A0D9SEI8|A0A0D9SEI8_HUMAN","sp|P16989|YBOX3_HUMAN",702,"P16989","YBOX3_HUMAN","Y-box-binding protein 3",null,"YBX3"]
["19.563","18.5829","20.2164","19.1857",{"$nulls":4},"peptidyl-prolyl cis-trans isomerase activity;phosphatase activator activity","cytoplasm;nucleoplasm",{"$nulls":3},5,5,5,21,21,21,"37.375",0,"12.07",108080000,11,"0.327634","0.70509","-0.628104","-0.883212","tr|A6PVN5|A6PVN5_HUMAN;sp|Q15257|PTPA_HUMAN;tr|A6PVN6|A6PVN6_HUMAN;tr|Q5T949|Q5T949_HUMAN;tr|Q5T948|Q5T948_HUMAN;tr|A6PVN9|A6PVN9_HUMAN;tr|F6WIT2|F6WIT2_HUMAN;tr|A6PVN8|A6PVN8_HUMAN;tr|C9IZ76|C9IZ76_HUMAN;tr|A6PVN7|A6PVN7_HUMAN;tr|Q68CR8|Q68CR8_HUMAN;tr|B7ZBP9|B7ZBP9_HUMAN;tr|B7ZBQ0|B7ZBQ0_HUMAN;tr|B7ZBP7|B7ZBP7_HUMAN;tr|B4DDQ6|B4DDQ6_HUMAN;tr|H0Y6E5|H0Y6E5_HUMAN","tr|A6PVN5|A6PVN5_HUMAN;sp|Q15257|PTPA_HUMAN;tr|A6PVN6|A6PVN6_HUMAN;tr|Q5T949|Q5T949_HUMAN;tr|Q5T948|Q5T948_HUMAN;tr|A6PVN9|A6PVN9_HUMAN;tr|F6WIT2|F6WIT2_HUMAN;tr|A6PVN8|A6PVN8_HUMAN;tr|C9IZ76|C9IZ76_HUMAN",1686,"A6PVN5","A6PVN5_HUMAN","Serine/threonine-protein phosphatase 2A activator {ECO:0000256|RuleBase:RU361210}",null,"PTPA"]
["18.409","18.1699","19.0085","18.8268",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;endosomal transport;retrograde transport, endosome to Golgi","actin binding;alpha-tubulin binding","cytosol;early endosome;early endosome membrane;recycling endosome;recycling endosome membrane;WASH complex",{"$nulls":3},1,1,1,"3.8","3.8","3.8","47.989",0,"39.451",57819000,9,"1.27851","0.328299","-0.628233","-4.18363","sp|Q9NQA3|WASH6_HUMAN","sp|Q9NQA3|WASH6_HUMAN",2667,"Q9NQA3","WASH6_HUMAN","WAS protein family homolog 6",null,"WASH6P"]
["19.1996","18.8948","19.8548","19.4967",{"$nulls":9},3,3,3,"13.1","13.1","13.1","38.893",0,"8.9563",112700000,7,"0.935251","0.298035","-0.628581","-2.67315","tr|A0A087WV52|A0A087WV52_HUMAN;sp|Q9NP92|RT30_HUMAN","tr|A0A087WV52|A0A087WV52_HUMAN;sp|Q9NP92|RT30_HUMAN",2657,"A0A087WV52"]
["14.4231",1,"15.6821",1,{"$nulls":3},"activation of GTPase activity;regulation of small GTPase mediated signal transduction","GTPase activator activity;protein heterodimerization activity",{"$nulls":4},2,2,2,"2.5","2.5","2.5","166.8",0,"3.9349",25971000,10,"0.0198631","0.974807","-0.6295","-0.0632876","sp|Q86X10|RLGPB_HUMAN;tr|A2A2F0|A2A2F0_HUMAN","sp|Q86X10|RLGPB_HUMAN;tr|A2A2F0|A2A2F0_HUMAN",1993,"Q86X10","RLGPB_HUMAN","Ral GTPase-activating protein subunit beta",null,"RALGAPB"]
["18.6468","18.5896","19.4067","19.0896",{"$nulls":3},"cell-matrix adhesion;cellular response to insulin stimulus;focal adhesion assembly;glucose transport;insulin receptor signaling pathway;muscle contraction;positive regulation of glucose import;positive regulation of glycogen biosynthetic process;positive regulation of lipid biosynthetic process;positive regulation of protein localization to plasma membrane;stress fiber assembly","actin binding;cytoskeletal protein binding;insulin receptor binding;SH3/SH2 adaptor activity","cell-cell adherens junction;cell-substrate adherens junction;centrosome;cytosol;focal adhesion;membrane raft;nuclear matrix;nucleus;plasma membrane;stress fiber;zonula adherens","Adherens junction;Insulin signaling pathway;PPAR signaling pathway",null,null,7,7,7,"8.5","8.5","8.5","142.51",0,"52.06",238930000,25,"1.22453","0.316179","-0.629958","-3.90962","sp|Q9BX66|SRBS1_HUMAN;tr|S4R406|S4R406_HUMAN;tr|S4R303|S4R303_HUMAN","sp|Q9BX66|SRBS1_HUMAN",2491,"Q9BX66","SRBS1_HUMAN","Sorbin and SH3 domain-containing protein 1",null,"SORBS1"]
["22.4987","22.0794","23.257","22.5815",{"$nulls":3},"DNA repair;DNA replication;DNA replication, removal of RNA primer;double-strand break repair;double-strand break repair via homologous recombination;memory;nucleic acid phosphodiester bond hydrolysis;positive regulation of sister chromatid cohesion;telomere maintenance via semi-conservative replication;UV protection","5'-3' exonuclease activity;5'-flap endonuclease activity;damaged DNA binding;DNA binding;double-stranded DNA binding;double-stranded DNA exodeoxyribonuclease activity;endonuclease activity;exonuclease activity;flap endonuclease activity;metal ion binding;RNA-DNA hybrid ribonuclease activity","membrane;mitochondrion;nuclear chromosome, telomeric region;nucleolus;nucleoplasm;nucleus;protein complex","Base excision repair;DNA replication;Non-homologous end-joining",null,null,9,9,9,30,30,30,"42.592",0,"131.82",1239200000,36,"0.595592","0.440746","-0.63021","-1.58541","sp|P39748|FEN1_HUMAN;tr|F5H1Y3|F5H1Y3_HUMAN;tr|I3L3E9|I3L3E9_HUMAN","sp|P39748|FEN1_HUMAN;tr|F5H1Y3|F5H1Y3_HUMAN",966,"P39748","FEN1_HUMAN","Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}","EN-1 {ECO:0000255|HAMAP-Rule:MF_03140}","FEN1"]
["22.6411","22.4458","23.758","22.5903",{"$nulls":3},"erythrocyte homeostasis;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleoplasm;ribosome","Ribosome",null,null,3,3,3,"33.3","33.3","33.3","15.55",0,"323.31",370720000,45,"0.399787","0.621807","-0.63064","-1.06536","sp|P08708|RS17_HUMAN;tr|H0YN88|H0YN88_HUMAN;tr|A0A075B716|A0A075B716_HUMAN","sp|P08708|RS17_HUMAN;tr|H0YN88|H0YN88_HUMAN;tr|A0A075B716|A0A075B716_HUMAN",569,"P08708","RS17_HUMAN","40S ribosomal protein S17 {ECO:0000305}",null,"RPS17"]
["17.7887","17.4719","19.1137","17.4097",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,2,2,2,"10.7","10.7","10.7","22.814","0.0011232","2.7919",41268000,3,"0.265995","0.756282","-0.631403","-0.728608","sp|Q7Z2W9|RM21_HUMAN;tr|F5H7V8|F5H7V8_HUMAN","sp|Q7Z2W9|RM21_HUMAN;tr|F5H7V8|F5H7V8_HUMAN",1944,"Q7Z2W9","RM21_HUMAN","39S ribosomal protein L21, mitochondrial","21mt;RP-L21","MRPL21"]
["18.2266","18.1833","18.7226","18.9503",{"$nulls":3},"microtubule-based movement","microtubule motor activity",{"$nulls":4},1,1,1,"5.9","5.9","5.9","21.735",0,"4.6986",37608000,9,"1.49384","0.320945","-0.631536","-5.44841","tr|H7C2F6|H7C2F6_HUMAN;sp|Q9Y496|KIF3A_HUMAN;tr|J3KPF9|J3KPF9_HUMAN;tr|A0A087X011|A0A087X011_HUMAN;tr|E9PES4|E9PES4_HUMAN","tr|H7C2F6|H7C2F6_HUMAN;sp|Q9Y496|KIF3A_HUMAN;tr|J3KPF9|J3KPF9_HUMAN;tr|A0A087X011|A0A087X011_HUMAN;tr|E9PES4|E9PES4_HUMAN",2994,"H7C2F6","H7C2F6_HUMAN",null,null,"KIF3A"]
["18.8153","19.1664","19.7598","19.4851",{"$nulls":4},"metal ion transmembrane transporter activity","integral component of membrane",{"$nulls":3},1,1,1,4,4,4,"30.912","0.0014075","2.3115",13658000,1,"0.977723","0.295325","-0.63159","-2.83333","tr|K7EQ91|K7EQ91_HUMAN;sp|Q13433|S39A6_HUMAN","tr|K7EQ91|K7EQ91_HUMAN;sp|Q13433|S39A6_HUMAN",1553,"K7EQ91","K7EQ91_HUMAN",null,null,"SLC39A6"]
["16.878","16.6664","17.2867","17.5216",{"$nulls":3},"GTP metabolic process;mature ribosome assembly","GTP binding;GTPase activity;ribosome binding;translation elongation factor activity",null,"Ribosome biogenesis in eukaryotes",null,null,3,3,3,"3.8","3.8","3.8","125.43",0,"9.4048",60159000,12,"1.24234","0.317954","-0.632002","-3.99833","sp|Q7Z2Z2|ETUD1_HUMAN","sp|Q7Z2Z2|ETUD1_HUMAN",1945,"Q7Z2Z2","EFL1_HUMAN","Elongation factor-like GTPase 1",null,"EFL1"]
["18.5565","18.32","19.4442","18.701",{"$nulls":3},"DNA replication;DNA replication, removal of RNA primer;mismatch repair;RNA catabolic process","metal ion binding;ribonuclease activity;RNA binding;RNA-DNA hybrid ribonuclease activity","cytosol;nucleoplasm;ribonuclease H2 complex","DNA replication",null,null,2,2,2,"12.4","12.4","12.4","33.395",0,"3.6413",62630000,9,"0.610259","0.4279","-0.634331","-1.6267","sp|O75792|RNH2A_HUMAN","sp|O75792|RNH2A_HUMAN",366,"O75792","RNH2A_HUMAN","Ribonuclease H2 subunit A","Nase H2 subunit A","RNASEH2A"]
["19.8687","19.8424","20.7258","20.2542",{"$nulls":9},1,1,1,"15.9","15.9","15.9","4.7233",0,"6.0578",36648000,7,"0.938812","0.29941","-0.634489","-2.68633","tr|M0R051|M0R051_HUMAN;tr|H0Y6Y8|H0Y6Y8_HUMAN;tr|B1AL05|B1AL05_HUMAN;sp|Q8N983|RM43_HUMAN","tr|M0R051|M0R051_HUMAN;tr|H0Y6Y8|H0Y6Y8_HUMAN;tr|B1AL05|B1AL05_HUMAN;sp|Q8N983|RM43_HUMAN",2067,"M0R051","M0R051_HUMAN",null,null,"MRPL43"]
["15.0467","14.1453","15.0549","15.4061",{"$nulls":9},1,1,1,"2.2","2.2","2.2","77.746","0.0010862","2.5077",7748300,1,"0.494954","0.517565","-0.634544","-1.31185","tr|B4DIW9|B4DIW9_HUMAN;sp|O15084|ANR28_HUMAN","tr|B4DIW9|B4DIW9_HUMAN;sp|O15084|ANR28_HUMAN",197,"B4DIW9","B4DIW9_HUMAN",null,null,"ANKRD28"]
["17.2413","17.7015","17.9945","18.2179",{"$nulls":5},"cytoplasm;microtubule organizing center;nucleoplasm","Glucagon signaling pathway",null,null,4,4,4,"7.9","7.9","7.9","95.367",0,"7.2634",81025000,12,"0.882178","0.302765","-0.634841","-2.48174","sp|Q6IN85|P4R3A_HUMAN;tr|G3V5A2|G3V5A2_HUMAN;tr|G3V5Z3|G3V5Z3_HUMAN;tr|G3V4R3|G3V4R3_HUMAN;tr|G3V231|G3V231_HUMAN;tr|H0YJN6|H0YJN6_HUMAN;tr|H0YIY8|H0YIY8_HUMAN;sp|Q5MIZ7|P4R3B_HUMAN","sp|Q6IN85|P4R3A_HUMAN;tr|G3V5A2|G3V5A2_HUMAN;tr|G3V5Z3|G3V5Z3_HUMAN",1870,"Q6IN85","P4R3A_HUMAN","Serine/threonine-protein phosphatase 4 regulatory subunit 3A {ECO:0000312|HGNC:HGNC:20219}",null,"PPP4R3A"]
["21.887","21.8108","22.6517","22.3176",{"$nulls":3},"chaperone mediated protein folding requiring cofactor;negative regulation of establishment of protein localization to mitochondrion;negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;negative regulation of p38MAPK cascade;positive regulation of MHC class I biosynthetic process;positive regulation of NK T cell activation;positive regulation of protein tyrosine kinase activity;positive regulation of transcription from RNA polymerase II promoter;receptor-mediated endocytosis;regulation of cellular response to heat;response to unfolded protein","adenyl-nucleotide exchange factor activity;alpha-tubulin binding;ATP binding","cytoplasm;cytosol;endocytic vesicle lumen;extracellular exosome;extracellular region;microtubule;nucleoplasm;protein complex","Protein processing in endoplasmic reticulum",null,null,25,25,24,"38.8","38.8","37.2","96.864",0,"323.31",2879900000,150,"1.18336","0.320105","-0.635741","-3.71081","sp|Q92598|HS105_HUMAN;tr|A0A0A0MSM0|A0A0A0MSM0_HUMAN;tr|R4GN69|R4GN69_HUMAN;tr|Q5TBM3|Q5TBM3_HUMAN","sp|Q92598|HS105_HUMAN;tr|A0A0A0MSM0|A0A0A0MSM0_HUMAN",2176,"Q92598","HS105_HUMAN","Heat shock protein 105 kDa",null,"HSPH1"]
["18.5886","19.308","19.9913","19.1769",{"$nulls":3},"acyl-CoA metabolic process;coenzyme A biosynthetic process;long-chain fatty-acyl-CoA catabolic process;medium-chain fatty acid biosynthetic process;medium-chain fatty-acyl-CoA catabolic process;palmitic acid biosynthetic process","acyl-CoA hydrolase activity;carboxylic ester hydrolase activity;fatty-acyl-CoA binding;long-chain fatty acyl-CoA binding;myristoyl-CoA hydrolase activity;palmitoyl-CoA hydrolase activity;protein homodimerization activity","cytosol;extracellular exosome;mitochondrion;nucleoplasm","Biosynthesis of unsaturated fatty acids;Fatty acid elongation",null,null,4,4,4,"15.3","15.3","15.3","41.796",0,"8.9939",164270000,27,"0.440759","0.562687","-0.635872","-1.17035","sp|O00154|BACH_HUMAN;tr|K7EKP8|K7EKP8_HUMAN","sp|O00154|BACH_HUMAN;tr|K7EKP8|K7EKP8_HUMAN",118,"O00154","BACH_HUMAN","Cytosolic acyl coenzyme A thioester hydrolase",null,"ACOT7"]
["15.8335","15.7113","16.7201","16.0979",{"$nulls":5},"cytosol;nucleoplasm",{"$nulls":3},1,1,1,"4.5","4.5","4.5","43.933","0.0011046","2.6785",8218700,1,"0.738912","0.342108","-0.636621","-2.00795","tr|F8VWL0|F8VWL0_HUMAN;tr|F8VX55|F8VX55_HUMAN;sp|Q12800|TFCP2_HUMAN","tr|F8VWL0|F8VWL0_HUMAN;tr|F8VX55|F8VX55_HUMAN;sp|Q12800|TFCP2_HUMAN",1495,"F8VWL0","F8VWL0_HUMAN",null,null,"TFCP2"]
["25.091","25.2219","26.0714","25.5158",{"$nulls":9},1,1,1,"23.9","23.9","23.9","5.4292",0,"12.776",1014600000,12,"0.808989","0.325934","-0.637144","-2.2324","tr|E5RIP1|E5RIP1_HUMAN;tr|E5RJX2|E5RJX2_HUMAN;sp|P60866|RS20_HUMAN","tr|E5RIP1|E5RIP1_HUMAN;tr|E5RJX2|E5RJX2_HUMAN;sp|P60866|RS20_HUMAN",1242,"E5RIP1","E5RIP1_HUMAN",null,null,"RPS20"]
["17.182","16.9348","18.0471","17.3456",{"$nulls":3},"hematopoietic stem cell homeostasis;inner cell mass cell differentiation;kidney development;negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;negative regulation of mitotic cell cycle;Notch signaling pathway;positive regulation of canonical Wnt signaling pathway;ribosomal large subunit assembly;skeletal system morphogenesis;somitogenesis",null,"nucleolus;nucleus;ribosome",{"$nulls":3},1,1,1,"2.5","2.5","2.5","53.32","0.001071","2.3899",38771000,1,"0.641266","0.404031","-0.637918","-1.71533","sp|Q9NVX2|NLE1_HUMAN","sp|Q9NVX2|NLE1_HUMAN",2724,"Q9NVX2","NLE1_HUMAN","Notchless protein homolog 1",null,"NLE1"]
["16.1213","16.1891","16.8041","16.7823",{"$nulls":3},"activation of GTPase activity;cellular response to insulin stimulus;intracellular protein transport;membrane organization;negative regulation of vesicle fusion;regulation of vesicle fusion;vesicle-mediated transport","GTPase activator activity;Rab GTPase binding","cytoplasmic vesicle membrane;cytosol;endomembrane system;extracellular exosome;intracellular","Insulin resistance;Thyroid hormone signaling pathway",null,null,3,3,3,"2.9","2.9","2.9","146.56",0,"9.4518",42099000,14,"2.50836","0.507826","-0.638009","-17.9129","sp|O60343|TBCD4_HUMAN","sp|O60343|TBCD4_HUMAN",286,"O60343","TBCD4_HUMAN","TBC1 domain family member 4",null,"TBC1D4"]
["16.9137","17.0464","17.4494","17.789",{"$nulls":3},"interleukin-1-mediated signaling pathway","ATP binding;protein serine/threonine kinase activity",{"$nulls":4},5,5,5,"12.1","12.1","12.1","76.059",0,"23.554",75741000,12,"1.13903","0.312456","-0.639168","-3.506","tr|D3YTB5|D3YTB5_HUMAN;sp|P51617|IRAK1_HUMAN;tr|H7C224|H7C224_HUMAN;tr|H7C2I6|H7C2I6_HUMAN;tr|H7C3C1|H7C3C1_HUMAN;tr|H7C3G8|H7C3G8_HUMAN;tr|F8WAB6|F8WAB6_HUMAN","tr|D3YTB5|D3YTB5_HUMAN;sp|P51617|IRAK1_HUMAN;tr|H7C224|H7C224_HUMAN;tr|H7C2I6|H7C2I6_HUMAN",1141,"D3YTB5","D3YTB5_HUMAN",null,null,"IRAK1"]
["16.8081","16.3438","17.5938","16.8373",{"$nulls":4},"ATP binding;MAP kinase kinase kinase activity","cytosol",{"$nulls":3},2,2,2,"7.5","7.5","7.5","51.582",0,"4.0643",20517000,3,"0.543187","0.485114","-0.63958","-1.44098","tr|D4Q8H0|D4Q8H0_HUMAN;sp|Q9NYL2|MLTK_HUMAN","tr|D4Q8H0|D4Q8H0_HUMAN;sp|Q9NYL2|MLTK_HUMAN",3078,"D4Q8H0","D4Q8H0_HUMAN",null,null,"pk"]
["17.365","16.7284","18.266","17.1074",{"$nulls":3},"metabolic process","catalytic activity",{"$nulls":4},1,1,1,"7.5","7.5","7.5","28.179",0,"15.126",25995000,4,"0.361413","0.667531","-0.639946","-0.96817","tr|H0Y5L2|H0Y5L2_HUMAN;sp|Q9NTX5|ECHD1_HUMAN","tr|H0Y5L2|H0Y5L2_HUMAN;sp|Q9NTX5|ECHD1_HUMAN",2701,"H0Y5L2","H0Y5L2_HUMAN",null,null,"ECHDC1"]
["24.7676","24.4548","25.3615","25.1414",{"$nulls":3},"actin cytoskeleton organization;androgen receptor signaling pathway;cell division;cellular protein complex localization;cellular response to mineralocorticoid stimulus;DNA metabolic process;hippocampus development;intracellular transport of virus;miRNA metabolic process;mitotic cell cycle;mitotic spindle organization;positive regulation of protein binding;positive regulation of transcription, DNA-templated;pre-miRNA export from nucleus;protein export from nucleus;protein import into nucleus;protein import into nucleus, translocation;protein localization to nucleolus;regulation of cholesterol biosynthetic process;regulation of gene silencing by miRNA;ribosomal large subunit export from nucleus;ribosomal small subunit export from nucleus;spermatid development;tRNA export from nucleus;viral process","androgen receptor binding;cadherin binding;chromatin binding;dynein intermediate chain binding;GDP binding;GTP binding;GTPase activity;importin-alpha family protein binding;magnesium ion binding;protein complex binding;protein domain specific binding;protein heterodimerization activity;RNA binding;transcription coactivator activity","centriole;cytoplasm;cytosol;extracellular exosome;extracellular matrix;host cell;male germ cell nucleus;manchette;melanosome;membrane;midbody;nuclear envelope;nuclear pore;nucleolus;nucleoplasm;nucleus;protein complex;recycling endosome;RNA nuclear export complex;sperm flagellum","Human T-cell leukemia virus 1 infection;Ribosome biogenesis in eukaryotes;RNA transport",null,null,7,7,7,"34.7","34.7","34.7","24.423",0,"18.625",3434000000,37,"1.10348","0.308462","-0.640227","-3.34828","sp|P62826|RAN_HUMAN;tr|B5MDF5|B5MDF5_HUMAN;tr|J3KQE5|J3KQE5_HUMAN;tr|F5H018|F5H018_HUMAN;tr|H0YFC6|H0YFC6_HUMAN;tr|B4DV51|B4DV51_HUMAN;tr|A0A087X0W0|A0A087X0W0_HUMAN","sp|P62826|RAN_HUMAN;tr|B5MDF5|B5MDF5_HUMAN;tr|J3KQE5|J3KQE5_HUMAN;tr|F5H018|F5H018_HUMAN",1316,"P62826","RAN_HUMAN","GTP-binding nuclear protein Ran",null,"RAN"]
["18.4997","18.5053","19.3574","18.9288",{"$nulls":3},"cellular response to glucose stimulus;cellular response to hypoxia;excitatory postsynaptic potential;lactation;nucleobase-containing compound metabolic process;nucleoside transport;sleep;uridine transport","nucleoside transmembrane transporter activity","apical plasma membrane;basolateral plasma membrane;integral component of plasma membrane;membrane;plasma membrane;postsynapse","Alcoholism",null,null,1,1,1,"4.4","4.4","4.4","50.219",0,"31.117",67638000,9,"1.01743","0.295393","-0.640605","-2.98912","sp|Q99808|S29A1_HUMAN","sp|Q99808|S29A1_HUMAN",2398,"Q99808","S29A1_HUMAN","Equilibrative nucleoside transporter 1",null,"SLC29A1"]
["18.3296","18.4096","19.5062","18.5151",{"$nulls":3},"neutrophil degranulation;ossification;signal transduction","SH3 domain binding","extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular;secretory granule lumen",{"$nulls":3},2,2,2,"17.3","17.3","17.3","23.787",0,"6.354",60082000,6,"0.486406","0.522552","-0.64099","-1.2893","sp|Q92882|OSTF1_HUMAN","sp|Q92882|OSTF1_HUMAN",2199,"Q92882","OSTF1_HUMAN","Osteoclast-stimulating factor 1",null,"OSTF1"]
["16.1926","15.3759","15.9414","16.9108",{"$nulls":3},"intracellular signal transduction;regulation of Rho protein signal transduction","cAMP-dependent protein kinase activity;metal ion binding;Rho guanyl-nucleotide exchange factor activity","cytosol",{"$nulls":3},2,2,2,"2.8","2.8","2.8","161.18",0,"9.7067",47333000,7,"0.379019","0.643277","-0.641794","-1.01265","tr|A0A087WTD7|A0A087WTD7_HUMAN;tr|A8MYJ1|A8MYJ1_HUMAN;sp|Q12802|AKP13_HUMAN;tr|A0A087WYS7|A0A087WYS7_HUMAN;tr|A0A087WX73|A0A087WX73_HUMAN;tr|A0A087WY36|A0A087WY36_HUMAN","tr|A0A087WTD7|A0A087WTD7_HUMAN;tr|A8MYJ1|A8MYJ1_HUMAN;sp|Q12802|AKP13_HUMAN;tr|A0A087WYS7|A0A087WYS7_HUMAN;tr|A0A087WX73|A0A087WX73_HUMAN;tr|A0A087WY36|A0A087WY36_HUMAN",1496,"A0A087WTD7","A0A087WTD7_HUMAN",null,null,"AKAP13"]
["18.6809","18.4191","19.0582","19.3274",{"$nulls":3},"carbohydrate metabolic process","catalytic activity","integral component of membrane",{"$nulls":3},7,1,1,60,"6.2","6.2","15.754","0.0056761","1.8715",38232000,1,"1.12074","0.310547","-0.642847","-3.42414","tr|F5H0E2|F5H0E2_HUMAN;tr|F5H867|F5H867_HUMAN;tr|F5GZR9|F5GZR9_HUMAN","tr|F5H0E2|F5H0E2_HUMAN;tr|F5H867|F5H867_HUMAN",3095,"F5H0E2","F5H0E2_HUMAN",null,null,"SLC3A2"]
["22.0228","21.9418","22.9775","22.2732",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"7.5","7.5","7.5","14.265",0,"4.1763",183470000,7,"0.67495","0.382817","-0.642982","-1.81385","tr|F8VNT9|F8VNT9_HUMAN;tr|F8VV56|F8VV56_HUMAN;tr|F8W022|F8W022_HUMAN;tr|F8VWK8|F8VWK8_HUMAN;sp|P08962|CD63_HUMAN","tr|F8VNT9|F8VNT9_HUMAN;tr|F8VV56|F8VV56_HUMAN;tr|F8W022|F8W022_HUMAN;tr|F8VWK8|F8VWK8_HUMAN;sp|P08962|CD63_HUMAN",574,"F8VNT9","F8VNT9_HUMAN",null,null,"CD63"]
["23.2075","22.7178","23.8994","23.3126",{"$nulls":3},"translation","structural constituent of ribosome","cytosol;endoplasmic reticulum;nucleolus;ribosome",{"$nulls":3},5,5,5,28,28,28,"18.756",0,"9.6806",753470000,16,"0.630176","0.414775","-0.643317","-1.68341","tr|G3V203|G3V203_HUMAN;tr|H0YHA7|H0YHA7_HUMAN;sp|Q07020|RL18_HUMAN;tr|J3QQ67|J3QQ67_HUMAN;tr|F8VUA6|F8VUA6_HUMAN;tr|F8VYV2|F8VYV2_HUMAN;tr|A0A075B7A0|A0A075B7A0_HUMAN","tr|G3V203|G3V203_HUMAN;tr|H0YHA7|H0YHA7_HUMAN;sp|Q07020|RL18_HUMAN;tr|J3QQ67|J3QQ67_HUMAN;tr|F8VUA6|F8VUA6_HUMAN;tr|F8VYV2|F8VYV2_HUMAN;tr|A0A075B7A0|A0A075B7A0_HUMAN",1462,"G3V203","G3V203_HUMAN"]
["16.4537","16.2853","17.2885","16.7371",{"$nulls":9},2,2,2,"8.8","8.8","8.8","38.072",0,"4.9644",17704000,3,"0.808801","0.325522","-0.643352","-2.23178","tr|G3V0G5|G3V0G5_HUMAN;sp|Q8IV38|ANKY2_HUMAN","tr|G3V0G5|G3V0G5_HUMAN;sp|Q8IV38|ANKY2_HUMAN",2007,"G3V0G5","G3V0G5_HUMAN"]
["21.5425","22.0261","22.5001","22.3578",{"$nulls":3},"alternative mRNA splicing, via spliceosome;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;RNA metabolic process","protein domain specific binding;RNA binding","catalytic step 2 spliceosome;extracellular exosome;extracellular matrix;integral component of plasma membrane;membrane;nuclear matrix;nucleolus;nucleoplasm;paraspeckles;spliceosomal complex","Spliceosome",null,null,17,17,11,"31.2","31.2","21.6","77.515",0,"126.83",1952200000,104,"0.903612","0.300754","-0.64467","-2.55791","sp|P52272|HNRPM_HUMAN;tr|A0A087X0X3|A0A087X0X3_HUMAN;tr|M0R019|M0R019_HUMAN;tr|M0R2T0|M0R2T0_HUMAN;tr|M0R2I7|M0R2I7_HUMAN;tr|M0R0N3|M0R0N3_HUMAN;tr|M0QYQ7|M0QYQ7_HUMAN;tr|M0R0Y6|M0R0Y6_HUMAN;tr|M0QYL3|M0QYL3_HUMAN;tr|M0QY96|M0QY96_HUMAN","sp|P52272|HNRPM_HUMAN;tr|A0A087X0X3|A0A087X0X3_HUMAN;tr|M0R019|M0R019_HUMAN",1152,"P52272","HNRPM_HUMAN","Heterogeneous nuclear ribonucleoprotein M","nRNP M","HNRNPM"]
["19.038","18.7166","19.5107","19.5338",{"$nulls":9},1,1,1,"9.6","9.6","9.6","16.437",0,"3.7524",59257000,6,"1.24334","0.319792","-0.644951","-4.00335","tr|B5MCE2|B5MCE2_HUMAN;tr|B4DRG3|B4DRG3_HUMAN;sp|Q9H6V9|LDAH_HUMAN;tr|B5MDU6|B5MDU6_HUMAN","tr|B5MCE2|B5MCE2_HUMAN;tr|B4DRG3|B4DRG3_HUMAN;sp|Q9H6V9|LDAH_HUMAN;tr|B5MDU6|B5MDU6_HUMAN",2607,"B5MCE2","B5MCE2_HUMAN",null,null,"LDAH"]
["21.1075","20.9179","21.969","21.3491",{"$nulls":3},"in utero embryonic development;placenta development;tRNA splicing, via endonucleolytic cleavage and ligation","ATP binding;metal ion binding;RNA binding;RNA ligase (ATP) activity;vinculin binding","cytoplasm;cytosol;endoplasmic reticulum membrane;intracellular membrane-bounded organelle;nuclear envelope;nucleoplasm;nucleus;tRNA-splicing ligase complex",{"$nulls":3},8,8,8,21,21,21,"55.21",0,"25.485",674750000,31,"0.734413","0.348911","-0.646333","-1.99397","sp|Q9Y3I0|RTCB_HUMAN","sp|Q9Y3I0|RTCB_HUMAN",2987,"Q9Y3I0","RTCB_HUMAN","tRNA-splicing ligase RtcB homolog {ECO:0000255|HAMAP-Rule:MF_03144}",null,"RTCB"]
["16.6865","16.5837","17.6432","16.9203",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;positive regulation of I-kappaB kinase/NF-kappaB signaling;transcription, DNA-templated","cadherin binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;signal transducer activity;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytosol;extracellular exosome;fibrillar center;membrane;microtubule organizing center;nucleus;plasma membrane",{"$nulls":3},3,3,3,"5.2","5.2","5.2","104.06",0,"12.108",64313000,10,"0.660553","0.390124","-0.646662","-1.77145","sp|Q6P1N0|C2D1A_HUMAN;tr|K7EJY5|K7EJY5_HUMAN","sp|Q6P1N0|C2D1A_HUMAN;tr|K7EJY5|K7EJY5_HUMAN",1883,"Q6P1N0","C2D1A_HUMAN","Coiled-coil and C2 domain-containing protein 1A",null,"CC2D1A"]
["17.2503","17.7735","18.2701","18.0475",{"$nulls":3},"cell cycle;cellular response to organic cyclic compound;histone H4-K16 acetylation;histone H4-K5 acetylation;histone H4-K8 acetylation;mitochondrion organization;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell cycle;positive regulation of gene expression;protein deubiquitination;protein stabilization;regulation of protein complex assembly;regulation of transcription, DNA-templated;release from viral latency;transcription from RNA polymerase II promoter","activating transcription factor binding;cadherin binding;chromatin binding;DNA binding transcription factor activity;identical protein binding;transcription coactivator activity;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding","axon;cytoplasm;dendrite;histone acetyltransferase complex;membrane;MLL1 complex;neuronal cell body;nucleoplasm;nucleus;Set1C/COMPASS complex","Herpes simplex virus 1 infection",null,null,9,9,9,"8.5","8.5","8.5","208.73",0,"14.786",163510000,24,"0.821973","0.322559","-0.646923","-2.27547","sp|P51610|HCFC1_HUMAN;tr|A6NEM2|A6NEM2_HUMAN;tr|H7C1C4|H7C1C4_HUMAN;sp|Q9Y5Z7|HCFC2_HUMAN","sp|P51610|HCFC1_HUMAN;tr|A6NEM2|A6NEM2_HUMAN",1140,"P51610","HCFC1_HUMAN","Host cell factor 1","CF;CF-1","HCFC1"]
["20.581","20.1279","21.6934","20.3095",{"$nulls":9},5,5,5,"31.7","31.7","31.7","32.611",0,"101.23",279940000,36,"0.329783","0.70253","-0.647002","-0.888607","tr|E9PJ81|E9PJ81_HUMAN;tr|E9PRQ7|E9PRQ7_HUMAN;sp|Q04323|UBXN1_HUMAN;tr|A0A087WTZ5|A0A087WTZ5_HUMAN;tr|E9PS08|E9PS08_HUMAN","tr|E9PJ81|E9PJ81_HUMAN;tr|E9PRQ7|E9PRQ7_HUMAN;sp|Q04323|UBXN1_HUMAN;tr|A0A087WTZ5|A0A087WTZ5_HUMAN",1441,"E9PJ81","E9PJ81_HUMAN",null,null,"UBXN1"]
["19.5974","19.2029","20.4539","19.6406",{"$nulls":3},"DNA replication;DNA replication initiation;DNA unwinding involved in DNA replication;G1/S transition of mitotic cell cycle","ATP binding;DNA helicase activity;single-stranded DNA binding","MCM complex;membrane;nuclear chromosome, telomeric region;nucleoplasm;nucleus","Cell cycle;DNA replication",null,null,15,15,15,"21.7","21.7","21.7","96.557",0,"127.47",456640000,51,"0.539808","0.486541","-0.647154","-1.43183","sp|P33991|MCM4_HUMAN;tr|E5RG31|E5RG31_HUMAN;tr|E5RFJ8|E5RFJ8_HUMAN","sp|P33991|MCM4_HUMAN",912,"P33991","MCM4_HUMAN","DNA replication licensing factor MCM4",null,"MCM4"]
["21.909","21.2013","22.3872","22.0174",{"$nulls":3},"maintenance of gastrointestinal epithelium;negative regulation of epithelial cell migration;negative regulation of epithelial cell proliferation;negative regulation of epithelial to mesenchymal transition;negative regulation of pathway-restricted SMAD protein phosphorylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transforming growth factor beta receptor signaling pathway;spliceosomal snRNP assembly","receptor binding;RNA binding","cytoplasm;cytosol;nucleoplasm;SMN complex;SMN-Sm protein complex","RNA transport",null,null,7,7,7,"28.6","28.6","28.6","38.438",0,"55.263",1064100000,47,"0.608156","0.428775","-0.647161","-1.62075","sp|Q9Y3F4|STRAP_HUMAN;tr|H0YH33|H0YH33_HUMAN","sp|Q9Y3F4|STRAP_HUMAN",2986,"Q9Y3F4","STRAP_HUMAN","Serine-threonine kinase receptor-associated protein",null,"STRAP"]
["18.5429","18.3756","19.469","18.7463",{"$nulls":4},"GTPase activator activity",{"$nulls":4},4,4,4,"24.1","24.1","24.1","30.597",0,"15.451",111030000,15,"0.65264","0.391346","-0.648444","-1.74833","tr|E9PQP3|E9PQP3_HUMAN;tr|A0A0D9SF70|A0A0D9SF70_HUMAN;tr|G5E9L0|G5E9L0_HUMAN;sp|Q8N6H7|ARFG2_HUMAN;tr|E9PIY6|E9PIY6_HUMAN;tr|E9PMR9|E9PMR9_HUMAN;tr|E9PM63|E9PM63_HUMAN;tr|H0YF45|H0YF45_HUMAN;tr|H0YDX1|H0YDX1_HUMAN;tr|E9PJT7|E9PJT7_HUMAN;tr|H0YDN9|H0YDN9_HUMAN;tr|E9PK28|E9PK28_HUMAN;tr|E9PN48|E9PN48_HUMAN","tr|E9PQP3|E9PQP3_HUMAN;tr|A0A0D9SF70|A0A0D9SF70_HUMAN;tr|G5E9L0|G5E9L0_HUMAN;sp|Q8N6H7|ARFG2_HUMAN;tr|E9PIY6|E9PIY6_HUMAN",2061,"E9PQP3","E9PQP3_HUMAN",null,null,"ARFGAP2"]
["16.9866","17.0717","18.4936","16.8617",{"$nulls":3},"co-translational protein modification;post-translational protein modification;protein N-linked glycosylation via asparagine","dolichyl-diphosphooligosaccharide-protein glycotransferase activity;metal ion binding","endoplasmic reticulum membrane;integral component of membrane;membrane;oligosaccharyltransferase complex","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,2,2,2,3,3,3,"80.529","0.0047393","1.961",73877000,4,"0.291934","0.740055","-0.648488","-0.793695","sp|P46977|STT3A_HUMAN;tr|H0YET6|H0YET6_HUMAN","sp|P46977|STT3A_HUMAN;tr|H0YET6|H0YET6_HUMAN",1043,"P46977","STT3A_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A","ligosaccharyl transferase subunit STT3A;TT3-A","STT3A"]
["16.4247","16.4471","16.9064","17.2625",{"$nulls":3},"angiogenesis;hyaluronan catabolic process;regulation of sprouting angiogenesis","cadherin binding;calcium ion binding;hyalurononglucosaminidase activity","extracellular exosome;integral component of membrane;integral component of plasma membrane",{"$nulls":3},4,4,4,"2.7","2.7","2.7","154.37",0,"8.8933",90032000,10,"1.1673","0.319226","-0.648582","-3.63554","sp|Q9UHN6|TMEM2_HUMAN;tr|B4E1B9|B4E1B9_HUMAN;tr|F5H6B2|F5H6B2_HUMAN","sp|Q9UHN6|TMEM2_HUMAN",2837,"Q9UHN6","TMEM2_HUMAN","Cell surface hyaluronidase {ECO:0000303|PubMed:28246172}",null,"TMEM2"]
["24.1615","24.0365","24.957","24.5404",{"$nulls":3},"angiogenesis;cellular response to epidermal growth factor stimulus;cellular response to leukemia inhibitory factor;negative regulation of translation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter","DNA topoisomerase binding;identical protein binding;mRNA 5'-UTR binding;protein C-terminus binding;RNA binding;telomeric DNA binding","cell cortex;cytoplasmic ribonucleoprotein granule;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus","Pathogenic Escherichia coli infection",null,null,15,15,15,"24.8","24.8","24.8","76.613",0,"323.31",6633200000,139,"1.01712","0.294847","-0.649678","-2.98785","sp|P19338|NUCL_HUMAN;tr|H7BY16|H7BY16_HUMAN;tr|C9JYW2|C9JYW2_HUMAN;tr|C9JLB1|C9JLB1_HUMAN;tr|C9J1H7|C9J1H7_HUMAN;tr|C9JWL1|C9JWL1_HUMAN","sp|P19338|NUCL_HUMAN;tr|H7BY16|H7BY16_HUMAN",728,"P19338","NUCL_HUMAN","Nucleolin",null,"NCL"]
["19.4939","18.9222","20.552","19.1653",{"$nulls":3},"apoptotic DNA fragmentation;chaperone-mediated protein folding;negative regulation of apoptotic DNA fragmentation;negative regulation of deoxyribonuclease activity;negative regulation of execution phase of apoptosis;positive regulation of apoptotic process;thymocyte apoptotic process","deoxyribonuclease inhibitor activity;protein binding involved in protein folding;protein domain specific binding","cytosol;nuclear chromatin;nucleoplasm;nucleus;plasma membrane","Apoptosis",null,null,3,3,3,"11.8","11.8","11.8","36.521",0,"7.6286",136720000,17,"0.321357","0.709552","-0.650573","-0.867464","sp|O00273|DFFA_HUMAN","sp|O00273|DFFA_HUMAN",132,"O00273","DFFA_HUMAN","DNA fragmentation factor subunit alpha",null,"DFFA"]
["19.0664","18.582","19.4512","19.4989",{"$nulls":4},"serine-type endopeptidase inhibitor activity","integral component of membrane",{"$nulls":3},1,1,1,"5.9","5.9","5.9","22.828","0.00038745","3.0951",51543000,4,"0.93545","0.298506","-0.650802","-2.67389","tr|K7EM91|K7EM91_HUMAN;sp|O43291|SPIT2_HUMAN","tr|K7EM91|K7EM91_HUMAN;sp|O43291|SPIT2_HUMAN",240,"K7EM91","K7EM91_HUMAN",null,null,"SPINT2"]
["19.1566","18.7501","19.839","19.3701",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,27,27,27,"7.2634",0,"3.6562",19545000,7,"0.767726","0.337938","-0.651222","-2.09865","tr|Q9HB66|Q9HB66_HUMAN","tr|Q9HB66|Q9HB66_HUMAN",3118,"Q9HB66","Q9HB66_HUMAN"]
["20.9075","20.9571","21.743","21.4242",{"$nulls":3},"base-excision repair;DNA damage response, detection of DNA damage;DNA replication;double-strand break repair via homologous recombination;error-free translesion synthesis;error-prone translesion synthesis;G1/S transition of mitotic cell cycle;interstrand cross-link repair;mismatch repair;mitotic G1 DNA damage checkpoint;nucleotide-excision repair;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;protein localization to chromosome;regulation of cellular response to heat;regulation of DNA damage checkpoint;regulation of double-strand break repair via homologous recombination;regulation of signal transduction by p53 class mediator;telomere maintenance;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","damaged DNA binding;enzyme binding;G-rich strand telomeric DNA binding;protein N-terminus binding;protein phosphatase binding;single-stranded DNA binding;ubiquitin protein ligase binding","chromatin;DNA replication factor A complex;nuclear body;nuclear chromosome, telomeric region;nucleoplasm;nucleus;PML body","DNA replication;Fanconi anemia pathway;Homologous recombination;Mismatch repair;Nucleotide excision repair",null,null,3,3,3,"24.8","24.8","24.8","29.247",0,"83.482",242280000,14,"1.24998","0.321651","-0.651322","-4.0369","sp|P15927|RFA2_HUMAN;tr|Q5TEJ7|Q5TEJ7_HUMAN;tr|Q5TEJ0|Q5TEJ0_HUMAN","sp|P15927|RFA2_HUMAN;tr|Q5TEJ7|Q5TEJ7_HUMAN",691,"P15927","RFA2_HUMAN","Replication protein A 32 kDa subunit","P-A p32","RPA2"]
["23.0984","22.9059","23.8219","23.4862",{"$nulls":4},"gamma-glutamylcyclotransferase activity",{"$nulls":4},5,5,5,"59.2","59.2","59.2","11.578",0,"30.274",798110000,28,"1.10822","0.309851","-0.65189","-3.36899","tr|M0QZK8|M0QZK8_HUMAN;sp|O75223|GGCT_HUMAN;tr|H7BZK5|H7BZK5_HUMAN;tr|B8ZZK2|B8ZZK2_HUMAN","tr|M0QZK8|M0QZK8_HUMAN;sp|O75223|GGCT_HUMAN",329,"M0QZK8","M0QZK8_HUMAN"]
["16.4659","15.846","17.3113","16.3067",{"$nulls":9},1,1,1,"12.4","12.4","12.4","19.382","0.00039651","3.3114",10255000,4,"0.415895","0.600043","-0.653069","-1.10646","tr|A0A0B4J287|A0A0B4J287_HUMAN;sp|Q9H0A8|COMD4_HUMAN;tr|H3BM91|H3BM91_HUMAN","tr|A0A0B4J287|A0A0B4J287_HUMAN;sp|Q9H0A8|COMD4_HUMAN;tr|H3BM91|H3BM91_HUMAN",2554,"A0A0B4J287","A0A0B4J287_HUMAN",null,null,"COMMD4"]
["14.603","14.7513","16.1825","14.4798",{"$nulls":9},2,2,2,"3.9","3.9","3.9","102.01",0,"5.7903",24228000,3,"0.280634","0.749553","-0.654041","-0.765357","tr|G3V4V5|G3V4V5_HUMAN;tr|H0YJP0|H0YJP0_HUMAN;sp|Q9ULT8|HECD1_HUMAN;tr|A0A087X2H1|A0A087X2H1_HUMAN","tr|G3V4V5|G3V4V5_HUMAN;tr|H0YJP0|H0YJP0_HUMAN;sp|Q9ULT8|HECD1_HUMAN;tr|A0A087X2H1|A0A087X2H1_HUMAN",2896,"G3V4V5","G3V4V5_HUMAN",null,null,"HECTD1"]
["19.6231","19.5137","20.3364","20.1107",{"$nulls":4},"hydrolase activity","mitochondrion",{"$nulls":3},4,4,4,"17.8","17.8","17.8","34.69",0,"29.086",137340000,24,"1.45922","0.320418","-0.655147","-5.22472","sp|Q8NFV4|ABHDB_HUMAN;tr|H7C396|H7C396_HUMAN;tr|C9J7Q4|C9J7Q4_HUMAN;tr|H7BZ58|H7BZ58_HUMAN;tr|H0YC52|H0YC52_HUMAN","sp|Q8NFV4|ABHDB_HUMAN;tr|H7C396|H7C396_HUMAN;tr|C9J7Q4|C9J7Q4_HUMAN;tr|H7BZ58|H7BZ58_HUMAN",2097,"Q8NFV4","ABHDB_HUMAN","Protein ABHD11 {ECO:0000305}",null,"ABHD11"]
["18.5412","17.8297","19.1223","18.5594",{"$nulls":3},"alpha-linolenic acid metabolic process;fatty acid beta-oxidation using acyl-CoA dehydrogenase;fatty acid beta-oxidation using acyl-CoA oxidase;fatty acid oxidation;generation of precursor metabolites and energy;lipid homeostasis;lipid metabolic process;peroxisome fission;positive regulation of cholesterol homeostasis;prostaglandin metabolic process;regulation of lipid metabolic process;spermatogenesis;very long-chain fatty acid metabolic process","acyl-CoA dehydrogenase activity;acyl-CoA oxidase activity;FAD binding;flavin adenine dinucleotide binding;palmitoyl-CoA oxidase activity;PDZ domain binding;protein N-terminus binding;receptor binding","intracellular membrane-bounded organelle;membrane;mitochondrion;nucleolus;nucleoplasm;nucleus;peroxisomal matrix;peroxisomal membrane;peroxisome;plasma membrane","alpha-Linolenic acid metabolism;beta-Alanine metabolism;Biosynthesis of unsaturated fatty acids;cAMP signaling pathway;Carbon metabolism;Fatty acid degradation;Fatty acid metabolism;Metabolic pathways;Peroxisome;PPAR signaling pathway;Propanoate metabolism",null,null,5,5,5,"14.7","14.7","14.7","74.423",0,"26.732",112370000,23,"0.544558","0.48504","-0.655382","-1.44471","sp|Q15067|ACOX1_HUMAN;tr|K7ELT1|K7ELT1_HUMAN;tr|I3L0T4|I3L0T4_HUMAN","sp|Q15067|ACOX1_HUMAN",1672,"Q15067","ACOX1_HUMAN","Peroxisomal acyl-coenzyme A oxidase 1 {ECO:0000303|PubMed:8117268}","OX {ECO:0000303|PubMed:8117268}","ACOX1"]
["19.8342","18.7402","20.5772","19.3093",{"$nulls":3},"glutamine metabolic process;GMP biosynthetic process;purine nucleobase biosynthetic process;purine ribonucleoside monophosphate biosynthetic process","ATP binding;GMP synthase (glutamine-hydrolyzing) activity;GMP synthase activity;pyrophosphatase activity","cytosol","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism",null,null,13,13,13,"22.7","22.7","22.7","76.715",0,"86.497",444590000,49,"0.287878","0.743377","-0.656045","-0.783525","sp|P49915|GUAA_HUMAN","sp|P49915|GUAA_HUMAN",1105,"P49915","GUAA_HUMAN","GMP synthase [glutamine-hydrolyzing]",null,"GMPS"]
["15.382","15.1267","16.3182","15.5028",{"$nulls":3},"signal transduction","3',5'-cyclic-nucleotide phosphodiesterase activity;metal ion binding",{"$nulls":4},1,1,1,"3.8","3.8","3.8","48.386","0.0097688","1.6882",11864000,3,"0.577821","0.459124","-0.656152","-1.53591","tr|D6RHE0|D6RHE0_HUMAN;tr|A0A087WSZ7|A0A087WSZ7_HUMAN;sp|Q08499|PDE4D_HUMAN","tr|D6RHE0|D6RHE0_HUMAN;tr|A0A087WSZ7|A0A087WSZ7_HUMAN;sp|Q08499|PDE4D_HUMAN",1476,"D6RHE0","D6RHE0_HUMAN","Phosphodiesterase {ECO:0000256|RuleBase:RU363067}",null,"PDE4D"]
["22.3294","22.6553","23.2191","23.0779",{"$nulls":3},"fibroblast growth factor receptor signaling pathway;interleukin-12-mediated signaling pathway;mRNA splicing, via spliceosome;regulation of RNA splicing;RNA metabolic process;RNA processing","RNA binding;single-stranded RNA binding;TBP-class protein binding","catalytic step 2 spliceosome;cytosol;membrane;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},7,7,5,"26.5","26.5",20,"45.671",0,"181.08",925300000,63,"1.18011","0.320689","-0.656156","-3.69548","sp|P52597|HNRPF_HUMAN","sp|P52597|HNRPF_HUMAN",1160,"P52597","HNRPF_HUMAN","Heterogeneous nuclear ribonucleoprotein F","nRNP F","HNRNPF"]
["19.626","19.6636","20.4301","20.1722",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},15,15,15,"16.6","16.6","16.6","141.44",0,"50.916",730250000,68,"1.42895","0.337788","-0.656323","-5.03585","tr|A0A024R4E5|A0A024R4E5_HUMAN;sp|Q00341|VIGLN_HUMAN;tr|H0Y394|H0Y394_HUMAN;tr|H7C0A4|H7C0A4_HUMAN;tr|C9JZI8|C9JZI8_HUMAN;tr|C9J5E5|C9J5E5_HUMAN;tr|C9JIZ1|C9JIZ1_HUMAN;tr|C9JHS7|C9JHS7_HUMAN;tr|C9JHZ8|C9JHZ8_HUMAN;tr|C9JES8|C9JES8_HUMAN;tr|C9JBS3|C9JBS3_HUMAN;tr|C9JEJ8|C9JEJ8_HUMAN;tr|C9JHN6|C9JHN6_HUMAN;tr|C9JT62|C9JT62_HUMAN;tr|C9JK79|C9JK79_HUMAN;tr|C9JMQ6|C9JMQ6_HUMAN;tr|C9JQ82|C9JQ82_HUMAN;tr|H7BZC3|H7BZC3_HUMAN;tr|H7C2D1|H7C2D1_HUMAN;tr|C9JHS9|C9JHS9_HUMAN;tr|C9J739|C9J739_HUMAN","tr|A0A024R4E5|A0A024R4E5_HUMAN;sp|Q00341|VIGLN_HUMAN;tr|H0Y394|H0Y394_HUMAN",3059,"A0A024R4E5","A0A024R4E5_HUMAN"]
["18.9222","19.0378","19.6077","19.6655",{"$nulls":3},"RNA phosphodiester bond hydrolysis, endonucleolytic","endoribonuclease activity;single-stranded RNA binding;zinc ion binding","mitochondrial matrix",{"$nulls":3},1,1,1,"3.8","3.8","3.8","32.805",0,"4.7433",93252000,14,"2.02035","0.402643","-0.656596","-10.1636","sp|Q53H82|LACB2_HUMAN","sp|Q53H82|LACB2_HUMAN",1797,"Q53H82","LACB2_HUMAN","Endoribonuclease LACTB2 {ECO:0000303|PubMed:26826708}",null,"LACTB2"]
["17.4931","17.4514","18.0759","18.1823",{"$nulls":3},"defense response to virus;interferon-beta production;protein K63-linked ubiquitination;regulation of type I interferon production;response to type I interferon","RNA binding;ubiquitin-protein transferase activity;zinc ion binding","cytoplasm;cytosol",{"$nulls":3},2,2,2,"3.4","3.4","3.4","81.487",0,"21.538",84904000,7,"2.12617","0.401538","-0.656869","-11.4984","sp|Q9BRZ2|TRI56_HUMAN","sp|Q9BRZ2|TRI56_HUMAN",2432,"Q9BRZ2","TRI56_HUMAN","E3 ubiquitin-protein ligase TRIM56",null,"TRIM56"]
["21.0923","21.1965","22.1936","21.4089",{"$nulls":3},"cellular response to hypoxia;DNA damage response, signal transduction by p53 class mediator;mast cell activation;negative regulation of cell proliferation;peripheral nervous system myelin maintenance;positive regulation of spindle checkpoint;regulation of apoptotic process;response to metal ion","cadherin binding;gamma-tubulin binding;microtubule binding;Rab GTPase binding","cell-cell adherens junction;centrosome;cytoplasm;cytosol;extracellular exosome;microtubule;microtubule cytoskeleton;myelin sheath;nucleus;perinuclear region of cytoplasm;plasma membrane;recycling endosome membrane",{"$nulls":3},5,5,5,"21.6","21.6","21.6","42.835",0,"18.837",282490000,28,"0.621828","0.422989","-0.656883","-1.65955","sp|Q92597|NDRG1_HUMAN;tr|E5RJY1|E5RJY1_HUMAN;tr|E7ESM1|E7ESM1_HUMAN;tr|E5RG99|E5RG99_HUMAN;tr|E5RIR1|E5RIR1_HUMAN;tr|E5RGM5|E5RGM5_HUMAN;tr|E5RIV1|E5RIV1_HUMAN;tr|E5RIM2|E5RIM2_HUMAN","sp|Q92597|NDRG1_HUMAN;tr|E5RJY1|E5RJY1_HUMAN;tr|E7ESM1|E7ESM1_HUMAN",2175,"Q92597","NDRG1_HUMAN","Protein NDRG1",null,"NDRG1"]
["16.3508","16.2291","17.2296","16.665",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;negative regulation of RNA export from nucleus;nuclear pore complex assembly;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;tRNA export from nucleus;viral entry into host cell;viral penetration into host nucleus;viral process;viral transcription","DNA binding;identical protein binding;metal ion binding;nuclear localization sequence binding;nucleocytoplasmic transporter activity;protein membrane anchor;structural constituent of nuclear pore","cytosol;host cell;nuclear inclusion body;nuclear membrane;nuclear periphery;nuclear pore;nuclear pore nuclear basket;nucleolus;nucleoplasm","RNA transport",null,null,4,4,4,"4.7","4.7","4.7","153.94",0,"8.188",61385000,13,"0.82222","0.322979","-0.657348","-2.27629","sp|P49790|NU153_HUMAN","sp|P49790|NU153_HUMAN",1096,"P49790","NU153_HUMAN","Nuclear pore complex protein Nup153",null,"NUP153"]
["20.0118","19.7439","21.0342","20.0378",{"$nulls":3},"activation of JUN kinase activity;adaptive immune response;angiogenesis;animal organ morphogenesis;B cell receptor signaling pathway;beta selection;blood vessel morphogenesis;cell proliferation;cellular response to low-density lipoprotein particle stimulus;cellular response to molecule of fungal origin;collagen-activated tyrosine kinase receptor signaling pathway;defense response to bacterium;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;inflammatory response;innate immune response;integrin-mediated signaling pathway;leukocyte activation involved in immune response;leukocyte cell-cell adhesion;leukotriene biosynthetic process;lymph vessel development;macrophage activation involved in immune response;neutrophil activation involved in immune response;neutrophil chemotaxis;peptidyl-serine phosphorylation;peptidyl-tyrosine autophosphorylation;platelet activation;positive regulation of alpha-beta T cell differentiation;positive regulation of alpha-beta T cell proliferation;positive regulation of B cell differentiation;positive regulation of bone resorption;positive regulation of calcium-mediated signaling;positive regulation of cell adhesion mediated by integrin;positive regulation of cytokine secretion;positive regulation of gamma-delta T cell differentiation;positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process;positive regulation of interleukin-3 biosynthetic process;positive regulation of mast cell degranulation;positive regulation of peptidyl-tyrosine autophosphorylation;positive regulation of receptor internalization;positive regulation of type I interferon production;protein phosphorylation;receptor internalization;regulation of arachidonic acid secretion;regulation of DNA binding transcription factor activity;regulation of ERK1 and ERK2 cascade;regulation of neutrophil degranulation;regulation of phagocytosis;regulation of platelet activation;regulation of platelet aggregation;regulation of superoxide anion generation;regulation of tumor necrosis factor-mediated signaling pathway;serotonin secretion by platelet;stimulatory C-type lectin receptor signaling pathway;transcription factor import into nucleus;transmembrane receptor protein tyrosine kinase signaling pathway;viral process","ATP binding;integrin binding;non-membrane spanning protein tyrosine kinase activity;phosphatase binding;phosphotyrosine residue binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;protein tyrosine kinase activity;SH2 domain binding;signal transducer, downstream of receptor, with protein tyrosine kinase activity;Toll-like receptor binding","B cell receptor complex;cytoplasm;cytosol;early phagosome;extrinsic component of cytoplasmic side of plasma membrane;nucleus;plasma membrane;protein complex;T cell receptor complex","B cell receptor signaling pathway;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Herpes simplex virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Natural killer cell mediated cytotoxicity;NF-kappa B signaling pathway;Osteoclast differentiation;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Platelet activation;Tuberculosis;Viral carcinogenesis",null,null,9,9,9,"24.3","24.3","24.3","72.065",0,"195.9",433000000,38,"0.481226","0.524276","-0.658099","-1.27568","sp|P43405|KSYK_HUMAN","sp|P43405|KSYK_HUMAN",1011,"P43405","KSYK_HUMAN","Tyrosine-protein kinase SYK",null,"SYK"]
["17.3101","17.3608","18.5681","17.421",{"$nulls":3},"cilium assembly;lipoprotein transport;neuron differentiation","lipid binding","ciliary transition zone;cilium;cytosol;intracellular",{"$nulls":3},1,1,1,"6.8","6.8","6.8","28.136","0.00039355","3.2344",34520000,5,"0.432113","0.578769","-0.659107","-1.14807","sp|A6NIH7|U119B_HUMAN","sp|A6NIH7|U119B_HUMAN",106,"A6NIH7","U119B_HUMAN","Protein unc-119 homolog B",null,"UNC119B"]
["22.1499","22.2696","22.9599","22.7779",{"$nulls":3},"exon-exon junction complex disassembly;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of translation","ribosome binding;RNA binding","cell junction;cytosol;exon-exon junction complex;nucleolus;nucleoplasm;nucleus","mRNA surveillance pathway;RNA transport",null,null,4,4,4,"29.9","29.9","29.9","22.655",0,"120.9",597500000,34,"1.58107","0.332956","-0.659128","-6.05143","sp|Q9BRP8|WIBG_HUMAN","sp|Q9BRP8|WIBG_HUMAN",2428,"Q9BRP8","PYM1_HUMAN","Partner of Y14 and mago {ECO:0000250|UniProtKB:P82804}",null,"PYM1"]
["20.0288","20.1034","20.7746","20.6778",{"$nulls":3},"IRES-dependent viral translational initiation;protein deubiquitination;translational initiation","thiol-dependent ubiquitin-specific protease activity;translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;membrane","RNA transport",null,null,5,5,5,"20.7","20.7","20.7","37.563",0,"40.895",244600000,30,"2.07246","0.406459","-0.660096","-10.8009","sp|O00303|EIF3F_HUMAN;tr|H0YDT6|H0YDT6_HUMAN;tr|A0A0D9SEZ9|A0A0D9SEZ9_HUMAN","sp|O00303|EIF3F_HUMAN",135,"O00303","EIF3F_HUMAN","Eukaryotic translation initiation factor 3 subunit F {ECO:0000255|HAMAP-Rule:MF_03005}","IF3f {ECO:0000255|HAMAP-Rule:MF_03005}","EIF3F"]
["19.3919","19.1884","19.9008","20.0032",{"$nulls":3},"cellular response to growth factor stimulus;endocytic recycling;pinocytosis;positive regulation of peptidyl-tyrosine phosphorylation;protein homooligomerization;regulation of endocytosis","ATP binding;cadherin binding;calcium ion binding;GTP binding;nucleic acid binding","early endosome membrane;endoplasmic reticulum;extracellular exosome;membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;recycling endosome membrane","Endocytosis",null,null,7,7,7,"21.1","21.1","21.1","61.174",0,"48.609",303980000,19,"1.54718","0.323083","-0.66188","-5.81026","sp|Q9H223|EHD4_HUMAN;tr|A0A087WUA5|A0A087WUA5_HUMAN","sp|Q9H223|EHD4_HUMAN;tr|A0A087WUA5|A0A087WUA5_HUMAN",2572,"Q9H223","EHD4_HUMAN","EH domain-containing protein 4 {ECO:0000305}",null,"EHD4"]
["23.4669","22.6149","23.8508","23.5548",{"$nulls":5},"cytosol;endoplasmic reticulum",{"$nulls":3},4,4,4,38,38,38,"12.201",0,"8.0428",728430000,21,"0.553066","0.476175","-0.661941","-1.46786","tr|E9PLL6|E9PLL6_HUMAN;sp|P46776|RL27A_HUMAN;tr|E9PJD9|E9PJD9_HUMAN;tr|E9PLX7|E9PLX7_HUMAN","tr|E9PLL6|E9PLL6_HUMAN;sp|P46776|RL27A_HUMAN;tr|E9PJD9|E9PJD9_HUMAN",1031,"E9PLL6","E9PLL6_HUMAN",null,null,"RPL27A"]
["18.5433","17.4272","19.0389","18.2555",{"$nulls":3},"galactose catabolic process;galactose catabolic process via UDP-galactose;galactose metabolic process;UDP-glucose catabolic process;UDP-glucose metabolic process","UDP-glucose:hexose-1-phosphate uridylyltransferase activity;zinc ion binding","cytosol;Golgi apparatus","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Metabolic pathways;Prolactin signaling pathway",null,null,2,2,2,"6.3","6.3","6.3","43.363","0.0010977","2.5999",56969000,3,"0.362528","0.66702","-0.661988","-0.970981","sp|P07902|GALT_HUMAN;tr|G3V3U5|G3V3U5_HUMAN;tr|G3V223|G3V223_HUMAN;tr|F2Z2X9|F2Z2X9_HUMAN;tr|G3V4G9|G3V4G9_HUMAN","sp|P07902|GALT_HUMAN;tr|G3V3U5|G3V3U5_HUMAN;tr|G3V223|G3V223_HUMAN;tr|F2Z2X9|F2Z2X9_HUMAN;tr|G3V4G9|G3V4G9_HUMAN",551,"P07902","GALT_HUMAN","Galactose-1-phosphate uridylyltransferase","al-1-P uridylyltransferase","GALT"]
["18.715","18.0887","19.0303","19.0987",{"$nulls":5},"cytoskeleton",{"$nulls":3},1,1,1,"9.5","9.5","9.5","12.122","0.0037697","2.0594",24195000,1,"0.769223","0.33785","-0.662634","-2.10342","tr|H0YFD8|H0YFD8_HUMAN;tr|H0Y9H2|H0Y9H2_HUMAN;tr|E7EV99|E7EV99_HUMAN;tr|E7ENY0|E7ENY0_HUMAN;sp|P35611|ADDA_HUMAN","tr|H0YFD8|H0YFD8_HUMAN;tr|H0Y9H2|H0Y9H2_HUMAN;tr|E7EV99|E7EV99_HUMAN;tr|E7ENY0|E7ENY0_HUMAN;sp|P35611|ADDA_HUMAN",935,"H0YFD8","H0YFD8_HUMAN",null,null,"ADD1"]
["14.7645","15.4725","15.5294","16.0346",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;nuclear pore complex assembly;nucleocytoplasmic transport;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;tRNA export from nucleus;viral process;viral transcription","structural constituent of nuclear pore","host cell;membrane;nuclear envelope;nuclear membrane;nuclear periphery;nuclear pore;nuclear pore inner ring","RNA transport",null,null,3,3,3,"1.9","1.9","1.9","227.92",0,"8.2226",49220000,5,"0.574105","0.463241","-0.663461","-1.52563","sp|Q92621|NU205_HUMAN","sp|Q92621|NU205_HUMAN",2182,"Q92621","NU205_HUMAN","Nuclear pore complex protein Nup205",null,"NUP205"]
["21.4491","20.8921","21.9998","21.6684",{"$nulls":3},"chromatin remodeling;covalent chromatin modification;positive regulation of gene expression, epigenetic;regulation of double-strand break repair;regulation of double-strand break repair via nonhomologous end joining;regulation of transcription from RNA polymerase II promoter;signal transduction;transcription from RNA polymerase II promoter;viral genome replication","chromatin binding;DNA binding;histone binding;RNA binding","contractile fiber;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"17.6","17.6","17.6","42.674",0,"37.854",445750000,29,"0.751498","0.339586","-0.663499","-2.04731","sp|P35659|DEK_HUMAN;tr|B4DFG0|B4DFG0_HUMAN;tr|H0Y993|H0Y993_HUMAN;tr|D6RDA2|D6RDA2_HUMAN;tr|D6R9L5|D6R9L5_HUMAN;tr|H0Y8X0|H0Y8X0_HUMAN","sp|P35659|DEK_HUMAN;tr|B4DFG0|B4DFG0_HUMAN;tr|H0Y993|H0Y993_HUMAN",939,"P35659","DEK_HUMAN","Protein DEK",null,"DEK"]
["20.5435","20.6019","21.5058","20.9671",{"$nulls":3},"adenine salvage;AMP salvage;cellular response to insulin stimulus;grooming behavior;lactation;neutrophil degranulation;purine ribonucleoside salvage;purine-containing compound salvage","adenine binding;adenine phosphoribosyltransferase activity;AMP binding","cytoplasm;cytosol;extracellular exosome;extracellular region;nucleoplasm;secretory granule lumen","Metabolic pathways;Purine metabolism",null,null,5,5,5,"31.7","31.7","31.7","19.608",0,"16.611",184890000,13,"0.873189","0.304306","-0.663764","-2.45023","sp|P07741|APT_HUMAN;tr|H3BQF1|H3BQF1_HUMAN;tr|H3BQB1|H3BQB1_HUMAN;tr|H3BQZ9|H3BQZ9_HUMAN;tr|H3BSW3|H3BSW3_HUMAN","sp|P07741|APT_HUMAN;tr|H3BQF1|H3BQF1_HUMAN;tr|H3BQB1|H3BQB1_HUMAN;tr|H3BQZ9|H3BQZ9_HUMAN",547,"P07741","APT_HUMAN","Adenine phosphoribosyltransferase","PRT","APRT"]
["20.2888","20.5384","21.6052","20.5511",{"$nulls":3},"response to calcium ion","calcium ion binding;protein homodimerization activity;RNA binding","cytosol;extracellular exosome;extracellular space;nucleolus;plasma membrane",{"$nulls":3},1,1,1,"11.7","11.7","11.7","11.801",0,"13.378",111110000,12,"0.46261","0.539295","-0.664532","-1.227","sp|Q96FQ6|S10AG_HUMAN","sp|Q96FQ6|S10AG_HUMAN",2268,"Q96FQ6","S10AG_HUMAN","Protein S100-A16",null,"S100A16"]
["18.8271","18.946","19.7184","19.3838",{"$nulls":3},"COPII vesicle coating","Rab guanyl-nucleotide exchange factor activity","cytosol;endoplasmic reticulum;Golgi apparatus;Golgi membrane;TRAPP complex",{"$nulls":3},2,2,2,"11.7","11.7","11.7","20.274",0,"4.6951",51802000,9,"1.19009","0.323648","-0.664556","-3.74273","sp|O43617|TPPC3_HUMAN;tr|A0A087WWM0|A0A087WWM0_HUMAN;tr|A0A087WYS5|A0A087WYS5_HUMAN;tr|A6NKE1|A6NKE1_HUMAN","sp|O43617|TPPC3_HUMAN;tr|A0A087WWM0|A0A087WWM0_HUMAN;tr|A0A087WYS5|A0A087WYS5_HUMAN;tr|A6NKE1|A6NKE1_HUMAN",253,"O43617","TPPC3_HUMAN","Trafficking protein particle complex subunit 3",null,"TRAPPC3"]
["20.5898","20.4504","21.3256","21.0459",{"$nulls":3},"fatty acid beta-oxidation;negative regulation of insulin secretion;response to activity;response to drug;response to insulin","3-hydroxyacyl-CoA dehydrogenase activity;NAD+ binding","cytoplasm;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;nucleoplasm","Butanoate metabolism;Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Lysine degradation;Metabolic pathways;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,7,7,7,"36.3","36.3","36.3","34.293",0,"37.144",229410000,25,"1.29277","0.334291","-0.665629","-4.25868","sp|Q16836|HCDH_HUMAN;tr|E9PF18|E9PF18_HUMAN;tr|A0A0A0MSE2|A0A0A0MSE2_HUMAN","sp|Q16836|HCDH_HUMAN;tr|E9PF18|E9PF18_HUMAN;tr|A0A0A0MSE2|A0A0A0MSE2_HUMAN",1758,"Q16836","HCDH_HUMAN","Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial","CDH","HADH"]
["17.765","18.3098","19.1909","18.2157",{"$nulls":3},"'de novo' IMP biosynthetic process;glutamine metabolic process;purine ribonucleoside monophosphate biosynthetic process;response to drug","ATP binding;metal ion binding;phosphoribosylformylglycinamidine synthase activity","cytoplasm;cytosol;extracellular exosome","Metabolic pathways;Purine metabolism",null,null,7,7,7,8,8,8,"144.73",0,"25.736",174510000,23,"0.44922","0.553084","-0.665904","-1.19222","sp|O15067|PUR4_HUMAN;tr|H0YGH1|H0YGH1_HUMAN;tr|J3KTL4|J3KTL4_HUMAN;tr|J3QSG0|J3QSG0_HUMAN;tr|J3QSH6|J3QSH6_HUMAN","sp|O15067|PUR4_HUMAN",195,"O15067","PUR4_HUMAN","Phosphoribosylformylglycinamidine synthase","GAM synthase;GAMS","PFAS"]
["19.8537","19.8247","20.8614","20.149",{"$nulls":3},"positive regulation of cell proliferation;protein refolding;response to heat","ATP binding;ATPase activator activity;chaperone binding;heat shock protein binding;metal ion binding;unfolded protein binding","cytosol;extracellular exosome;membrane","Protein processing in endoplasmic reticulum",null,null,7,7,7,"28.6","28.6","28.6","45.745",0,"167.58",264970000,36,"0.693242","0.373489","-0.665986","-1.86839","sp|O60884|DNJA2_HUMAN;tr|A0A087WT48|A0A087WT48_HUMAN","sp|O60884|DNJA2_HUMAN",313,"O60884","DNJA2_HUMAN","DnaJ homolog subfamily A member 2",null,"DNAJA2"]
["15.4638","17.4988","16.844","17.451",{"$nulls":3},"regulation of autophagy",null,"extracellular space",{"$nulls":3},4,4,4,"4.3","4.3","4.3","115.76",0,"4.9597",67533000,5,"0.225888","0.79669","-0.666244","-0.627457","tr|X6R3R3|X6R3R3_HUMAN;sp|O94964|SOGA1_HUMAN;tr|H0YDM2|H0YDM2_HUMAN","tr|X6R3R3|X6R3R3_HUMAN;sp|O94964|SOGA1_HUMAN;tr|H0YDM2|H0YDM2_HUMAN",403,"X6R3R3","X6R3R3_HUMAN",null,null,"SOGA1"]
["14.853","14.4905","15.5864","15.0902",{"$nulls":3},"establishment of protein localization to endoplasmic reticulum membrane;intracellular protein transport;positive regulation of autophagosome assembly;positive regulation of endoplasmic reticulum tubular network organization;positive regulation of protein lipidation;regulation of GTPase activity","enzyme activator activity;enzyme regulator activity;GTPase activator activity;protein heterodimerization activity;Rab GTPase binding","cytosol;endoplasmic reticulum membrane;plasma membrane;protein complex",{"$nulls":3},2,2,2,"2.4","2.4","2.4","155.98","0.0010772","2.4209",25963000,3,"0.789649","0.33305","-0.666516","-2.16913","sp|Q9H2M9|RBGPR_HUMAN","sp|Q9H2M9|RBGPR_HUMAN",2579,"Q9H2M9","RBGPR_HUMAN","Rab3 GTPase-activating protein non-catalytic subunit",null,"RAB3GAP2"]
["21.2758","20.4117","21.701","21.3216",{"$nulls":4},"RNA binding",{"$nulls":4},6,6,6,"32.1","32.1","32.1","26.743",0,"29.025",283260000,26,"0.533466","0.495036","-0.667516","-1.41469","tr|A0A087WX29|A0A087WX29_HUMAN;sp|Q13148|TADBP_HUMAN;tr|B1AKP7|B1AKP7_HUMAN;tr|G3V162|G3V162_HUMAN;tr|A0A087X260|A0A087X260_HUMAN;tr|A0A087WYY0|A0A087WYY0_HUMAN;tr|K7EJM5|K7EJM5_HUMAN;tr|K7EN94|K7EN94_HUMAN;tr|A0A087WXQ5|A0A087WXQ5_HUMAN;tr|A0A087WV68|A0A087WV68_HUMAN;tr|A0A087WTZ4|A0A087WTZ4_HUMAN;tr|K7EL26|K7EL26_HUMAN;tr|K7EJ99|K7EJ99_HUMAN;tr|A0A0A0MSV7|A0A0A0MSV7_HUMAN;tr|A0A087WYE7|A0A087WYE7_HUMAN;tr|A0A087WZC9|A0A087WZC9_HUMAN;tr|A0A087WW61|A0A087WW61_HUMAN;tr|A0A087WX67|A0A087WX67_HUMAN;tr|A0A087WXV3|A0A087WXV3_HUMAN","tr|A0A087WX29|A0A087WX29_HUMAN;sp|Q13148|TADBP_HUMAN;tr|B1AKP7|B1AKP7_HUMAN;tr|G3V162|G3V162_HUMAN;tr|A0A087X260|A0A087X260_HUMAN;tr|A0A087WYY0|A0A087WYY0_HUMAN;tr|K7EJM5|K7EJM5_HUMAN;tr|K7EN94|K7EN94_HUMAN",1527,"A0A087WX29","A0A087WX29_HUMAN",null,null,"TARDBP"]
["18.8394","18.8011","19.9577","19.0181",{"$nulls":3},"activation of innate immune response;heart development;innate immune response;negative regulation of cyclin-dependent protein serine/threonine kinase activity;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of signal transduction by p53 class mediator;transcription, DNA-templated","7SK snRNA binding;cyclin-dependent protein serine/threonine kinase inhibitor activity;snRNA binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"11.7","11.7","11.7","40.623",0,"6.0361",71765000,12,"0.535476","0.49219","-0.667719","-1.42011","sp|O94992|HEXI1_HUMAN","sp|O94992|HEXI1_HUMAN",407,"O94992","HEXI1_HUMAN","Protein HEXIM1",null,"HEXIM1"]
["17.8545","17.784","18.6684","18.3058",{"$nulls":3},"cell growth;cell projection organization;cellular iron ion homeostasis;centrosome localization;iron-sulfur cluster assembly;negative regulation of centrosome duplication;protein localization to cell cortex","4 iron, 4 sulfur cluster binding;ATP binding;iron-sulfur cluster binding;metal ion binding;nucleotide binding","centriole;cilium;cytosol;extracellular exosome;nucleus;plasma membrane",{"$nulls":3},2,2,2,"11.2","11.2","11.2","34.534",0,"3.7931",36004000,10,"1.16301","0.313798","-0.66783","-3.61561","sp|P53384|NUBP1_HUMAN;tr|I3L531|I3L531_HUMAN","sp|P53384|NUBP1_HUMAN;tr|I3L531|I3L531_HUMAN",1178,"P53384","NUBP1_HUMAN","Cytosolic Fe-S cluster assembly factor NUBP1 {ECO:0000255|HAMAP-Rule:MF_03038}",null,"NUBP1"]
["23.7059","23.58","24.5025","24.12",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,5,5,5,"15.894","0.001127","2.8141",311600000,6,"1.09671","0.30727","-0.668286","-3.3189","tr|F5GXT1|F5GXT1_HUMAN;tr|A6NNI4|A6NNI4_HUMAN;tr|A0A087WZG3|A0A087WZG3_HUMAN;tr|A0A087WU13|A0A087WU13_HUMAN;tr|G8JLH6|G8JLH6_HUMAN;sp|P21926|CD9_HUMAN","tr|F5GXT1|F5GXT1_HUMAN;tr|A6NNI4|A6NNI4_HUMAN;tr|A0A087WZG3|A0A087WZG3_HUMAN;tr|A0A087WU13|A0A087WU13_HUMAN;tr|G8JLH6|G8JLH6_HUMAN;sp|P21926|CD9_HUMAN",758,"F5GXT1","F5GXT1_HUMAN",null,null,"CD9"]
["21.9697","21.7275","22.8098","22.2243",{"$nulls":3},"embryonic organ development;global genome nucleotide-excision repair;nucleotide-excision repair;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, preincision complex assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein folding;regulation of proteasomal ubiquitin-dependent protein catabolic process;spermatogenesis","damaged DNA binding;polyubiquitin modification-dependent protein binding;single-stranded DNA binding","cytosol;nucleoplasm;nucleus;proteasome complex;XPC complex","Nucleotide excision repair;Protein processing in endoplasmic reticulum",null,null,5,5,5,"16.1","16.1","16.1","43.171",0,"77.407",683610000,34,"0.771264","0.338024","-0.668466","-2.10994","sp|P54727|RD23B_HUMAN;tr|Q5W0S5|Q5W0S5_HUMAN;tr|K7ENJ0|K7ENJ0_HUMAN;tr|K7ELW1|K7ELW1_HUMAN;sp|P54725|RD23A_HUMAN;tr|Q5W0S4|Q5W0S4_HUMAN;tr|H0Y579|H0Y579_HUMAN","sp|P54727|RD23B_HUMAN;tr|Q5W0S5|Q5W0S5_HUMAN",1195,"P54727","RD23B_HUMAN","UV excision repair protein RAD23 homolog B","HR23B;R23B","RAD23B"]
["18.7346","18.5732","19.3819","19.2664",{"$nulls":4},"metal ion binding;protein serine/threonine phosphatase activity",{"$nulls":4},1,1,1,"4.2","4.2","4.2","31.263",0,"10.096",72777000,2,"1.67316","0.338864","-0.670239","-6.75429","tr|B5MCT7|B5MCT7_HUMAN;sp|P49593|PPM1F_HUMAN","tr|B5MCT7|B5MCT7_HUMAN;sp|P49593|PPM1F_HUMAN",1083,"B5MCT7","B5MCT7_HUMAN"]
["21.5787","21.1897","22.2491","21.8608",{"$nulls":3},"protein catabolic process","ATP binding;proteasome-activating ATPase activity","cytoplasm",{"$nulls":3},11,11,11,"38.1","38.1","38.1","47.352",0,"301.01",931740000,59,"0.87037","0.304554","-0.670743","-2.4404","tr|R4GNH3|R4GNH3_HUMAN;tr|E9PM69|E9PM69_HUMAN;sp|P17980|PRS6A_HUMAN;tr|E9PN50|E9PN50_HUMAN;tr|E9PKD5|E9PKD5_HUMAN;tr|E9PMD8|E9PMD8_HUMAN;tr|E9PLG2|E9PLG2_HUMAN","tr|R4GNH3|R4GNH3_HUMAN;tr|E9PM69|E9PM69_HUMAN;sp|P17980|PRS6A_HUMAN;tr|E9PN50|E9PN50_HUMAN;tr|E9PKD5|E9PKD5_HUMAN;tr|E9PMD8|E9PMD8_HUMAN",3120,"R4GNH3","R4GNH3_HUMAN",null,null,"PSMC3"]
["18.5404","18.407","19.3173","18.9726",{"$nulls":4},"methyltransferase activity",{"$nulls":4},1,1,1,"9.8","9.8","9.8","16.93",0,"4.2515",32437000,9,"1.16659","0.318182","-0.67122","-3.63223","tr|B4E349|B4E349_HUMAN;tr|F5H6D8|F5H6D8_HUMAN;tr|B4DTN4|B4DTN4_HUMAN;sp|Q86U44|MTA70_HUMAN","tr|B4E349|B4E349_HUMAN;tr|F5H6D8|F5H6D8_HUMAN;tr|B4DTN4|B4DTN4_HUMAN;sp|Q86U44|MTA70_HUMAN",1976,"B4E349","B4E349_HUMAN",null,null,"METTL3"]
["14.9952","15.0549","15.6689","15.7241",{"$nulls":3},"positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein ubiquitination;protein folding","enzyme inhibitor activity",null,"Protein processing in endoplasmic reticulum",null,null,1,1,1,"4.4","4.4","4.4","39.474","0.00039216","3.2037",8991000,2,"2.4381","0.493699","-0.671488","-16.5144","sp|Q9NZL4|HPBP1_HUMAN","sp|Q9NZL4|HPBP1_HUMAN",2759,"Q9NZL4","HPBP1_HUMAN","Hsp70-binding protein 1","spBP1","HSPBP1"]
["18.5778","18.62","19.5615","18.9803",{"$nulls":3},"chaperone-mediated protein transport;protein import into mitochondrial inner membrane;protein targeting to mitochondrion;sensory perception of sound","protein transporter activity;zinc ion binding","fibrillar center;mitochondrial inner membrane;mitochondrial intermembrane space protein transporter complex;mitochondrion",{"$nulls":3},1,1,1,"14.7","14.7","14.7","10.5","0.0010714","2.392",27971000,2,"0.831244","0.313848","-0.672034","-2.30652","sp|Q9Y5L4|TIM13_HUMAN","sp|Q9Y5L4|TIM13_HUMAN",3021,"Q9Y5L4","TIM13_HUMAN","Mitochondrial import inner membrane translocase subunit Tim13",null,"TIMM13"]
["20.0363","19.7954","20.6545","20.5228",{"$nulls":3},"glycosphingolipid metabolic process;lipid transport","identical protein binding;lipid binding;metal ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;intracellular membrane-bounded organelle;membrane;organelle membrane contact site;plasma membrane",{"$nulls":3},18,18,18,"25.9","25.9","25.9","122.85",0,"56.356",691910000,92,"1.40659","0.332921","-0.672785","-4.90029","sp|Q9BSJ8|ESYT1_HUMAN;tr|F8VZB1|F8VZB1_HUMAN","sp|Q9BSJ8|ESYT1_HUMAN",2437,"Q9BSJ8","ESYT1_HUMAN","Extended synaptotagmin-1",{"$f":"-#REF!","v":{"$error":"#REF!"}},"ESYT1"]
["17.8208","17.9275","18.6199","18.4764",{"$nulls":3},"circadian regulation of gene expression;negative regulation of epithelial cell proliferation;negative regulation of transcription, DNA-templated;positive regulation of apoptotic signaling pathway;positive regulation of branching involved in ureteric bud morphogenesis;positive regulation of MAP kinase activity;positive regulation of transcription, DNA-templated;regulation of apoptotic process;regulation of circadian rhythm;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated","identical protein binding;transcription coactivator activity","chromatin;cytoplasm;nucleus;plasma membrane;protein complex","Neurotrophin signaling pathway",null,null,3,2,2,"5.4","3.9","3.9","86.16",0,"323.31",81318000,16,"1.76587","0.354974","-0.673965","-7.53862","sp|Q9Y5V3|MAGD1_HUMAN","sp|Q9Y5V3|MAGD1_HUMAN",3028,"Q9Y5V3","MAGD1_HUMAN","Melanoma-associated antigen D1",null,"MAGED1"]
["19.7285","20.1099","20.6978","20.489",{"$nulls":3},"cellular protein modification process","ATP binding;catalytic activity",{"$nulls":4},9,9,9,"20.7","20.7","20.7","74.403",0,"16.693",423330000,34,"1.04498","0.302491","-0.674129","-3.10077","sp|Q14166|TTL12_HUMAN","sp|Q14166|TTL12_HUMAN",1608,"Q14166","TTL12_HUMAN","Tubulin--tyrosine ligase-like protein 12",null,"TTLL12"]
["16.1133",1,1,"17.4631",{"$nulls":9},1,1,1,"2.7","2.7","2.7","37.791","0.0037633","2.0535",11478000,1,"0.0189372","0.975935","-0.674871","-0.0603958","tr|E9PNH0|E9PNH0_HUMAN;tr|H0YCD7|H0YCD7_HUMAN;sp|Q9H0X9|OSBL5_HUMAN","tr|E9PNH0|E9PNH0_HUMAN;tr|H0YCD7|H0YCD7_HUMAN;sp|Q9H0X9|OSBL5_HUMAN",2566,"E9PNH0","E9PNH0_HUMAN",null,null,"OSBPL5"]
["16.4637","15.8929","16.885","16.8228",{"$nulls":3},"mitochondrial fission;peroxisome fission","GTP binding;GTPase activity","cytosol;intracellular membrane-bounded organelle",{"$nulls":3},12,1,1,"26.8","2.9","2.9","79.621",0,"9.2166",40990000,9,"0.845097","0.309208","-0.675604","-2.35339","tr|G8JLD5|G8JLD5_HUMAN","tr|G8JLD5|G8JLD5_HUMAN",3099,"G8JLD5","G8JLD5_HUMAN",null,null,"DNM1L"]
["15.632","15.3394","16.6432","15.6795",{"$nulls":3},"signal transduction","DNA binding;protein complex scaffold activity","centrosome;Golgi apparatus;intracellular membrane-bounded organelle",{"$nulls":3},9,9,9,3,3,3,"453.49",0,"57.368",158030000,23,"0.50623","0.514614","-0.675631","-1.34175","tr|A0A0A0MRF6|A0A0A0MRF6_HUMAN;sp|Q99996|AKAP9_HUMAN;tr|A0A0A0MRE9|A0A0A0MRE9_HUMAN;tr|H7BYL6|H7BYL6_HUMAN;tr|A0A087WX84|A0A087WX84_HUMAN;tr|H7BZV6|H7BZV6_HUMAN;tr|Q6PJH3|Q6PJH3_HUMAN","tr|A0A0A0MRF6|A0A0A0MRF6_HUMAN;sp|Q99996|AKAP9_HUMAN;tr|A0A0A0MRE9|A0A0A0MRE9_HUMAN",2404,"A0A0A0MRF6","A0A0A0MRF6_HUMAN",null,null,"AKAP9"]
["21.8429","21.9094","22.6513","22.4538",{"$nulls":9},5,5,5,"15.4","15.4","15.4","46.228",0,"84.973",832950000,43,"1.63973","0.330043","-0.676352","-6.49078","tr|A0A0A6YYC3|A0A0A6YYC3_HUMAN;sp|Q9Y383|LC7L2_HUMAN;tr|A0A0A6YYJ8|A0A0A6YYJ8_HUMAN;tr|A8MYV2|A8MYV2_HUMAN;sp|Q9NQ29|LUC7L_HUMAN;tr|B8ZZ10|B8ZZ10_HUMAN;tr|B8ZZ12|B8ZZ12_HUMAN;tr|B8ZZ09|B8ZZ09_HUMAN","tr|A0A0A6YYC3|A0A0A6YYC3_HUMAN;sp|Q9Y383|LC7L2_HUMAN;tr|A0A0A6YYJ8|A0A0A6YYJ8_HUMAN;tr|A8MYV2|A8MYV2_HUMAN;sp|Q9NQ29|LUC7L_HUMAN",2975,"A0A0A6YYC3"]
["22.0096","21.5818","22.7481","22.1963",{"$nulls":3},"[2Fe-2S] cluster assembly;cell redox homeostasis;negative regulation of cardiac muscle hypertrophy;protein maturation by iron-sulfur cluster transfer;regulation of the force of heart contraction","electron transfer activity;identical protein binding;iron-sulfur cluster binding;metal ion binding;protein disulfide oxidoreductase activity;protein kinase C binding;RNA binding","cell cortex;cytosol;dendrite;extracellular exosome;nucleus;Z disc",{"$nulls":3},9,9,9,"38.8","38.8","38.8","37.432",0,"269.2",1000100000,47,"0.716157","0.359816","-0.676488","-1.93779","sp|O76003|GLRX3_HUMAN","sp|O76003|GLRX3_HUMAN",383,"O76003","GLRX3_HUMAN","Glutaredoxin-3",null,"GLRX3"]
["19.4704","19.455","20.6052","19.6739",{"$nulls":3},"B cell differentiation;B cell mediated immunity;cell cycle arrest;determination of adult lifespan;DNA repair;double-strand break repair;germ cell development;in utero embryonic development;intra-S DNA damage checkpoint;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;isotype switching;maintenance of DNA repeat elements;male gonad development;meiotic gene conversion;mismatch repair;negative regulation of DNA recombination;negative regulation of neuron apoptotic process;negative regulation of reciprocal meiotic recombination;oxidative phosphorylation;positive regulation of helicase activity;positive regulation of isotype switching to IgA isotypes;positive regulation of isotype switching to IgG isotypes;postreplication repair;response to UV-B;response to X-ray;somatic hypermutation of immunoglobulin genes;somatic recombination of immunoglobulin gene segments","ATP binding;centromeric DNA binding;damaged DNA binding;DNA binding;DNA-dependent ATPase activity;double-strand/single-strand DNA junction binding;enzyme binding;guanine/thymine mispair binding;heteroduplex DNA loop binding;protein C-terminus binding;protein homodimerization activity;protein kinase binding;Y-form DNA binding","membrane;MutSalpha complex;MutSbeta complex;nuclear chromosome, telomeric region;nucleoplasm","Colorectal cancer;Mismatch repair;Pathways in cancer;Platinum drug resistance",null,null,10,10,9,"14.5","14.5","13.2","104.74",0,"130.93",536230000,40,"0.547769","0.484682","-0.67688","-1.45343","sp|P43246|MSH2_HUMAN;tr|V9H019|V9H019_HUMAN;tr|E9PHA6|E9PHA6_HUMAN;tr|A0A087X078|A0A087X078_HUMAN;tr|A0A087X1E7|A0A087X1E7_HUMAN;tr|V9H015|V9H015_HUMAN;tr|V9H0B2|V9H0B2_HUMAN","sp|P43246|MSH2_HUMAN;tr|V9H019|V9H019_HUMAN;tr|E9PHA6|E9PHA6_HUMAN;tr|A0A087X078|A0A087X078_HUMAN",1006,"P43246","MSH2_HUMAN","DNA mismatch repair protein Msh2","MSH2","MSH2"]
["17.2873","17.002","17.7231","17.9261",{"$nulls":3},"adipose tissue development;DNA dealkylation involved in DNA repair;DNA demethylation;oxidative demethylation;oxidative single-stranded DNA demethylation;oxidative single-stranded RNA demethylation;regulation of brown fat cell differentiation;regulation of lipid storage;regulation of multicellular organism growth;regulation of respiratory system process;regulation of white fat cell proliferation;RNA repair;temperature homeostasis","DNA-N1-methyladenine dioxygenase activity;ferrous iron binding;oxidative DNA demethylase activity;oxidative RNA demethylase activity;RNA N6-methyladenosine dioxygenase activity","nuclear speck;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"3.8","3.8","3.8","58.281",0,"5.6843",39388000,10,"1.21924","0.315058","-0.679994","-3.8836","sp|Q9C0B1|FTO_HUMAN","sp|Q9C0B1|FTO_HUMAN",2529,"Q9C0B1","FTO_HUMAN","Alpha-ketoglutarate-dependent dioxygenase FTO",null,"FTO"]
["17.332","17.3051","18.2515","17.7458",{"$nulls":4},"actin binding;calcium ion binding;microtubule binding","cytoskeleton",{"$nulls":3},34,34,34,"6.8","6.8","6.8","856.87",0,"214.03",992310000,137,"0.938658","0.298931","-0.680056","-2.68576","tr|H3BPE1|H3BPE1_HUMAN;tr|H3BQK9|H3BQK9_HUMAN;sp|Q9UPN3|MACF1_HUMAN;tr|H0Y390|H0Y390_HUMAN;tr|E9PNZ4|E9PNZ4_HUMAN;tr|H0YD69|H0YD69_HUMAN;tr|H0Y314|H0Y314_HUMAN;tr|E9PLY5|E9PLY5_HUMAN;tr|H0Y6T5|H0Y6T5_HUMAN;tr|H0Y4F5|H0Y4F5_HUMAN;tr|E9PLY0|E9PLY0_HUMAN","tr|H3BPE1|H3BPE1_HUMAN;tr|H3BQK9|H3BQK9_HUMAN;sp|Q9UPN3|MACF1_HUMAN;tr|H0Y390|H0Y390_HUMAN",3104,"H3BPE1","H3BPE1_HUMAN",null,null,"MACF1"]
["17.2015","17.7142","18.4638","17.8137",{"$nulls":3},"maternal process involved in female pregnancy;NLS-bearing protein import into nucleus;positive regulation of transcription from RNA polymerase II promoter","nuclear localization sequence binding;protein transporter activity","cytosol;membrane;nuclear pore;nucleoplasm",{"$nulls":3},4,2,2,"11.6","6.2","6.2","60.029",0,"12.048",58867000,11,"0.616564","0.425054","-0.680848","-1.64457","sp|O60684|IMA7_HUMAN;sp|O15131|IMA6_HUMAN;tr|S4R3E5|S4R3E5_HUMAN;tr|Q5TFJ7|Q5TFJ7_HUMAN","sp|O60684|IMA7_HUMAN;sp|O15131|IMA6_HUMAN",299,"O60684","IMA7_HUMAN","Importin subunit alpha-7",null,"KPNA6"]
["18.7463","19.9036","19.9533","20.0595",{"$nulls":9},4,4,4,"33.8","33.8","33.8","16.956",0,"8.6142",105760000,14,"0.441659","0.563184","-0.681456","-1.17267","tr|A0A096LPJ4|A0A096LPJ4_HUMAN;sp|P05161|ISG15_HUMAN;tr|A0A096LNZ9|A0A096LNZ9_HUMAN","tr|A0A096LPJ4|A0A096LPJ4_HUMAN;sp|P05161|ISG15_HUMAN;tr|A0A096LNZ9|A0A096LNZ9_HUMAN",514,"A0A096LPJ4","A0A096LPJ4_HUMAN",null,null,"ISG15"]
["19.0542","18.7281","19.8013","19.3485",{"$nulls":3},"proline biosynthetic process","pyrroline-5-carboxylate reductase activity","mitochondrion",{"$nulls":3},3,3,3,"17.5","17.5","17.5","25.868",0,"10.606",110320000,24,"0.873257","0.304739","-0.683722","-2.45046","tr|A0A087WTV6|A0A087WTV6_HUMAN;sp|Q96C36|P5CR2_HUMAN;tr|A0A087WZR9|A0A087WZR9_HUMAN;tr|J3KR12|J3KR12_HUMAN","tr|A0A087WTV6|A0A087WTV6_HUMAN;sp|Q96C36|P5CR2_HUMAN;tr|A0A087WZR9|A0A087WZR9_HUMAN",2243,"A0A087WTV6","A0A087WTV6_HUMAN",null,null,"PYCR2"]
["23.3585","23.7155","24.3814","24.0605",{"$nulls":3},"DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;establishment of skin barrier;intrinsic apoptotic signaling pathway in response to DNA damage;keratinization;keratinocyte development;membrane organization;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of keratinocyte proliferation;negative regulation of protein kinase activity;positive regulation of cell growth;positive regulation of epidermal cell differentiation;positive regulation of protein export from nucleus;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;regulation of cyclin-dependent protein serine/threonine kinase activity;regulation of epidermal cell division;release of cytochrome c from mitochondria;signal transduction","cadherin binding;identical protein binding;phosphoprotein binding;protein domain specific binding;protein kinase binding;protein kinase C inhibitor activity","cytoplasmic vesicle membrane;cytosol;extracellular exosome;extracellular space;mitochondrion;nucleus","Aldosterone-regulated sodium reabsorption;Cell cycle;p53 signaling pathway",null,null,10,7,7,"40.3","30.2","30.2","27.774",0,"53.513",2084900000,45,"0.981907","0.295487","-0.683931","-2.84946","sp|P31947|1433S_HUMAN","sp|P31947|1433S_HUMAN",897,"P31947","1433S_HUMAN","14-3-3 protein sigma",null,"SFN"]
["19.5007","19.1574","20.0786","19.9509",{"$nulls":5},"cytosol;nucleoplasm",{"$nulls":3},3,3,3,"22.4","22.4","22.4","32.253",0,"27.843",114830000,20,"1.19042","0.324513","-0.685692","-3.74432","tr|H0YN81|H0YN81_HUMAN;sp|Q9GZS3|WDR61_HUMAN;tr|H0YMF9|H0YMF9_HUMAN;tr|H0YM76|H0YM76_HUMAN;tr|H0YLA1|H0YLA1_HUMAN;tr|H3BQA8|H3BQA8_HUMAN;tr|H0YL19|H0YL19_HUMAN","tr|H0YN81|H0YN81_HUMAN;sp|Q9GZS3|WDR61_HUMAN;tr|H0YMF9|H0YMF9_HUMAN",2540,"H0YN81","H0YN81_HUMAN",null,null,"WDR61"]
["17.1025","17.0113","17.5304","17.9558",{"$nulls":3},"rRNA base methylation","RNA binding;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity","nucleolus;nucleus",{"$nulls":3},2,2,2,"7.7","7.7","7.7","46.691","0.00076423","2.9617",47847000,4,"1.05794","0.305113","-0.686242","-3.15438","sp|Q96P11|NSUN5_HUMAN;sp|Q63ZY6|NSN5C_HUMAN","sp|Q96P11|NSUN5_HUMAN;sp|Q63ZY6|NSN5C_HUMAN",2330,"Q96P11","NSUN5_HUMAN","Probable 28S rRNA (cytosine-C(5))-methyltransferase",null,"NSUN5"]
["13.1663","12.6822","14.2142","13.0088",{"$nulls":3},"Golgi to endosome transport;mitochondrion organization;negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization",null,"cytoplasm;cytosol;extracellular exosome;mitochondrial outer membrane",{"$nulls":3},2,2,2,"0.7","0.7","0.7","422.39",0,"3.6485",16102000,4,"0.396935","0.623436","-0.68726","-1.0581","sp|Q709C8|VP13C_HUMAN","sp|Q709C8|VP13C_HUMAN",1921,"Q709C8","VP13C_HUMAN","Vacuolar protein sorting-associated protein 13C",null,"VPS13C"]
["18.9912","18.8223","19.5502","19.6385",{"$nulls":3},"phenylalanyl-tRNA aminoacylation;protein heterotetramerization;tRNA aminoacylation for protein translation","ATP binding;phenylalanine-tRNA ligase activity;RNA binding;tRNA binding","cytoplasm;cytosol;membrane;phenylalanine-tRNA ligase complex","Aminoacyl-tRNA biosynthesis",null,null,4,4,4,10,10,10,"57.563",0,"9.556",137630000,26,"1.7289","0.357367","-0.687643","-7.21612","sp|Q9Y285|SYFA_HUMAN;tr|K7ER00|K7ER00_HUMAN;tr|K7ER16|K7ER16_HUMAN;tr|K7EK06|K7EK06_HUMAN;tr|K7EPH2|K7EPH2_HUMAN","sp|Q9Y285|SYFA_HUMAN;tr|K7ER00|K7ER00_HUMAN;tr|K7ER16|K7ER16_HUMAN",2945,"Q9Y285","SYFA_HUMAN","Phenylalanine--tRNA ligase alpha subunit",null,"FARSA"]
["20.1174","19.5405","21.0168","20.02",{"$nulls":3},"mRNA stabilization;positive regulation of translation;response to cold;response to UV;stress granule assembly","mRNA 3'-UTR binding;RNA binding;small ribosomal subunit rRNA binding;translation repressor activity","cytoplasm;cytoplasmic stress granule;nucleolus;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"26.7","26.7","26.7","18.648",0,"48.052",124150000,14,"0.45114","0.552279","-0.689431","-1.1972","sp|Q14011|CIRBP_HUMAN;tr|K7ENX8|K7ENX8_HUMAN;tr|K7ELV6|K7ELV6_HUMAN;tr|K7EJV5|K7EJV5_HUMAN;tr|K7ELT6|K7ELT6_HUMAN;tr|K7EJV1|K7EJV1_HUMAN;tr|K7EMY9|K7EMY9_HUMAN;tr|K7EPM4|K7EPM4_HUMAN;tr|K7ER40|K7ER40_HUMAN;tr|K7EQR7|K7EQR7_HUMAN;tr|D6W5Y5|D6W5Y5_HUMAN;tr|K7EQX4|K7EQX4_HUMAN;tr|K7ENN6|K7ENN6_HUMAN;tr|K7EIF7|K7EIF7_HUMAN;tr|K7EQL0|K7EQL0_HUMAN","sp|Q14011|CIRBP_HUMAN;tr|K7ENX8|K7ENX8_HUMAN;tr|K7ELV6|K7ELV6_HUMAN;tr|K7EJV5|K7EJV5_HUMAN;tr|K7ELT6|K7ELT6_HUMAN;tr|K7EJV1|K7EJV1_HUMAN;tr|K7EMY9|K7EMY9_HUMAN;tr|K7EPM4|K7EPM4_HUMAN;tr|K7ER40|K7ER40_HUMAN;tr|K7EQR7|K7EQR7_HUMAN;tr|D6W5Y5|D6W5Y5_HUMAN",1595,"Q14011","CIRBP_HUMAN","Cold-inducible RNA-binding protein",null,"CIRBP"]
["18.5488","18.1036","19.4256","18.6084",{"$nulls":9},1,1,1,"4.1","4.1","4.1","34.488","0.000757","2.8713",52603000,3,"0.559156","0.470093","-0.690799","-1.48451","tr|K7EMZ9|K7EMZ9_HUMAN;sp|Q8ND56|LS14A_HUMAN","tr|K7EMZ9|K7EMZ9_HUMAN;sp|Q8ND56|LS14A_HUMAN",2087,"K7EMZ9","K7EMZ9_HUMAN",null,null,"LSM14A"]
["19.1037","19.0173","19.8677","19.6363",{"$nulls":3},"sensory perception of sound","ubiquitin protein ligase binding","cytosol",{"$nulls":3},2,2,2,"7.2","7.2","7.2","35.822",0,"69.868",93185000,17,"1.51626","0.325415","-0.691474","-5.59793","sp|Q8IVM0|CCD50_HUMAN","sp|Q8IVM0|CCD50_HUMAN",2009,"Q8IVM0","CCD50_HUMAN","Coiled-coil domain-containing protein 50",null,"CCDC50"]
["20.9655","20.9238","21.8766","21.396",{"$nulls":3},"membrane protein proteolysis;membrane protein proteolysis involved in retrograde protein transport, ER to cytosol;protein homotetramerization","aspartic endopeptidase activity, intramembrane cleaving;peptidase activity;protein homodimerization activity;ubiquitin protein ligase binding","cell surface;Derlin-1 retrotranslocation complex;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi-associated vesicle membrane;integral component of cytoplasmic side of endoplasmic reticulum membrane;integral component of lumenal side of endoplasmic reticulum membrane;lysosomal membrane;membrane;plasma membrane;rough endoplasmic reticulum",{"$nulls":3},3,3,3,"13.8","13.8","13.8","41.488",0,"14.774",472150000,19,"0.986626","0.297884","-0.691691","-2.86774","sp|Q8TCT9|HM13_HUMAN;tr|A0A075B6F6|A0A075B6F6_HUMAN;tr|A0A0C4DGU3|A0A0C4DGU3_HUMAN","sp|Q8TCT9|HM13_HUMAN;tr|A0A075B6F6|A0A075B6F6_HUMAN",2117,"Q8TCT9","HM13_HUMAN","Minor histocompatibility antigen H13",null,"HM13"]
["19.3877","19.4478","20.1573","20.0617",{"$nulls":4},"zinc ion binding",{"$nulls":4},5,5,5,"24.4","24.4","24.4","42.542",0,"24.846",197930000,33,"2.18072","0.426894","-0.69179","-12.2519","tr|H7C0E5|H7C0E5_HUMAN;sp|O75312|ZPR1_HUMAN;tr|H7BZM7|H7BZM7_HUMAN;tr|H7C449|H7C449_HUMAN","tr|H7C0E5|H7C0E5_HUMAN;sp|O75312|ZPR1_HUMAN;tr|H7BZM7|H7BZM7_HUMAN",331,"H7C0E5","H7C0E5_HUMAN",null,null,"ZPR1"]
["17.7507","17.7275","18.6254","18.2386",{"$nulls":4},"zinc ion binding","nucleus",{"$nulls":3},3,3,3,"10.5","10.5","10.5","50.562",0,"7.5417",78406000,8,"1.15465","0.310493","-0.692893","-3.5771","tr|C9J0I9|C9J0I9_HUMAN;sp|Q86WB0|NIPA_HUMAN;tr|F8WAU5|F8WAU5_HUMAN","tr|C9J0I9|C9J0I9_HUMAN;sp|Q86WB0|NIPA_HUMAN",1992,"C9J0I9","C9J0I9_HUMAN",null,null,"ZC3HC1"]
["16.5184",1,"17.9052",1,{"$nulls":9},1,1,1,"13.9","13.9","13.9","12.981","0.0010699","2.3892",8079900,4,"0.0189492","0.976106","-0.693412","-0.0604334","tr|A0A087WV30|A0A087WV30_HUMAN;tr|C9JH59|C9JH59_HUMAN;tr|C9J2V2|C9J2V2_HUMAN;tr|C9JN51|C9JN51_HUMAN;tr|A0A087X0G7|A0A087X0G7_HUMAN;tr|A0A087WUW6|A0A087WUW6_HUMAN;tr|A0A087X1B1|A0A087X1B1_HUMAN;sp|Q9Y6K9|NEMO_HUMAN","tr|A0A087WV30|A0A087WV30_HUMAN;tr|C9JH59|C9JH59_HUMAN;tr|C9J2V2|C9J2V2_HUMAN;tr|C9JN51|C9JN51_HUMAN;tr|A0A087X0G7|A0A087X0G7_HUMAN;tr|A0A087WUW6|A0A087WUW6_HUMAN;tr|A0A087X1B1|A0A087X1B1_HUMAN;sp|Q9Y6K9|NEMO_HUMAN",3053,"A0A087WV30","A0A087WV30_HUMAN",null,null,"IKBKG"]
["18.5254","18.3806","19.3199","18.9759",{"$nulls":3},"apoptotic process;camera-type eye development;cell fate specification;chaperone-mediated protein folding;dorsal/ventral neural tube patterning;intracellular signal transduction;multicellular organism growth;negative regulation of apoptotic process;negative regulation of protein phosphorylation;positive regulation of BMP signaling pathway;smoothened signaling pathway;viral process","disordered domain specific binding;FK506 binding;identical protein binding;metal ion binding;peptidyl-prolyl cis-trans isomerase activity","cytoplasm;cytosol;endoplasmic reticulum;integral component of endoplasmic reticulum membrane;membrane;mitochondrial membrane;mitochondrion;protein complex",{"$nulls":3},4,4,4,"18.4","18.4","18.4","44.561",0,"10.741",87339000,21,"1.18607","0.323492","-0.694903","-3.72365","sp|Q14318|FKBP8_HUMAN;tr|M0R2K9|M0R2K9_HUMAN;tr|U3KQI1|U3KQI1_HUMAN;tr|M0R1Q0|M0R1Q0_HUMAN;tr|M0R1S6|M0R1S6_HUMAN;tr|U3KQ64|U3KQ64_HUMAN;tr|M0R2Q6|M0R2Q6_HUMAN;tr|A0A0A0MTJ1|A0A0A0MTJ1_HUMAN","sp|Q14318|FKBP8_HUMAN;tr|M0R2K9|M0R2K9_HUMAN",1618,"Q14318","FKBP8_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP8","PIase FKBP8","FKBP8"]
["18.3366","17.9177","19.2393","18.4052",{"$nulls":5},"cytosol;intracellular membrane-bounded organelle;nucleolus;WASH complex",{"$nulls":3},12,12,3,"16.7","16.7","4.2","136.86",0,"65.092",199470000,35,"0.561016","0.472075","-0.695125","-1.4896","tr|F8W7U3|F8W7U3_HUMAN;tr|E7ESD2|E7ESD2_HUMAN;sp|Q641Q2|FA21A_HUMAN;tr|A0A087WYF6|A0A087WYF6_HUMAN;tr|A0A0A0MT65|A0A0A0MT65_HUMAN;sp|Q5SRD0|FA21D_HUMAN;tr|B1AP61|B1AP61_HUMAN","tr|F8W7U3|F8W7U3_HUMAN;tr|E7ESD2|E7ESD2_HUMAN;sp|Q641Q2|FA21A_HUMAN;tr|A0A087WYF6|A0A087WYF6_HUMAN",1854,"F8W7U3","F8W7U3_HUMAN",null,null,"WASHC2A"]
["20.1747","19.782","20.9573","20.3939",{"$nulls":3},"cytoplasmic mRNA processing body assembly;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;negative regulation of neuron differentiation;regulation of translation;RNA secondary structure unwinding;spermatogenesis;stem cell population maintenance;viral RNA genome packaging","ATP binding;ATP-dependent RNA helicase activity;cadherin binding;helicase activity;protein domain specific binding;RNA binding;RNA helicase activity","cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;heterochromatin;membrane;mitochondrion;nucleolus;nucleus;outer dense fiber;P granule;P-body;RISC complex;sperm annulus","RNA degradation",null,null,6,6,6,"18.8","18.8","18.8","54.416",0,"39.964",446030000,37,"0.74615","0.342778","-0.697253","-2.03053","sp|P26196|DDX6_HUMAN;tr|Q8IV96|Q8IV96_HUMAN","sp|P26196|DDX6_HUMAN;tr|Q8IV96|Q8IV96_HUMAN",806,"P26196","DDX6_HUMAN","Probable ATP-dependent RNA helicase DDX6 {ECO:0000305}",null,"DDX6"]
["16.6844","16.5281","17.2578","17.3494",{"$nulls":3},"epithelial cell differentiation;mRNA splicing, via spliceosome;RNA processing;RNA splicing","RNA binding","nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},2,2,2,"6.6","6.6","6.6","36.926",0,"4.4349",16750000,4,"1.7837","0.363126","-0.697347","-7.69908","sp|P31942|HNRH3_HUMAN","sp|P31942|HNRH3_HUMAN",894,"P31942","HNRH3_HUMAN","Heterogeneous nuclear ribonucleoprotein H3","nRNP H3","HNRNPH3"]
["20.8715","20.8676","21.7406","21.3941",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"14.9","14.9","14.9","7.9924","0.0027826","2.2051",64503000,3,"1.24807","0.320719","-0.697801","-4.02722","tr|Q5JWB9|Q5JWB9_HUMAN;sp|Q96A57|TM230_HUMAN;tr|A0A087WTT2|A0A087WTT2_HUMAN","tr|Q5JWB9|Q5JWB9_HUMAN;sp|Q96A57|TM230_HUMAN;tr|A0A087WTT2|A0A087WTT2_HUMAN",2228,"Q5JWB9","Q5JWB9_HUMAN",null,null,"TMEM230"]
["23.2181","23.4492","23.8757","24.1874",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;regulation of transcription, DNA-templated;ribosomal large subunit assembly;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;DNA binding;RNA binding;structural constituent of ribosome","cytoplasmic ribonucleoprotein granule;cytosol;cytosolic large ribosomal subunit;focal adhesion;membrane;nucleus","Ribosome",null,null,10,10,10,"30.2","30.2","30.2","32.728",0,"126.77",1659000000,76,"1.15894","0.313941","-0.697881","-3.5968","sp|Q02878|RL6_HUMAN;tr|F8VZ45|F8VZ45_HUMAN;tr|U3KQR5|U3KQR5_HUMAN;tr|F8VR69|F8VR69_HUMAN;tr|F8VZA3|F8VZA3_HUMAN;tr|F8VWR1|F8VWR1_HUMAN;tr|F8VU16|F8VU16_HUMAN","sp|Q02878|RL6_HUMAN",1434,"Q02878","RL6_HUMAN","60S ribosomal protein L6",null,"RPL6"]
["19.3591","19.4588","20.2145","20.0003",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;identical protein binding;protein heterodimerization activity;transcription corepressor activity","nucleus",{"$nulls":3},2,2,2,"15.6","15.6","15.6","22.35","0.00039904","3.3458",66015000,7,"1.56167","0.334392","-0.698512","-5.91226","sp|Q14919|NC2A_HUMAN;tr|C9JCC6|C9JCC6_HUMAN;tr|E9PNC7|E9PNC7_HUMAN;tr|E9PMW2|E9PMW2_HUMAN;tr|E9PQX9|E9PQX9_HUMAN","sp|Q14919|NC2A_HUMAN;tr|C9JCC6|C9JCC6_HUMAN;tr|E9PNC7|E9PNC7_HUMAN;tr|E9PMW2|E9PMW2_HUMAN;tr|E9PQX9|E9PQX9_HUMAN",1649,"Q14919","NC2A_HUMAN","Dr1-associated corepressor",null,"DRAP1"]
["20.4774","20.5198","21.324","21.0723",{"$nulls":3},"cell proliferation;cellular response to DNA damage stimulus;cellular response to epidermal growth factor stimulus;cellular response to xenobiotic stimulus;DNA replication;DNA replication initiation;DNA unwinding involved in DNA replication;G1/S transition of mitotic cell cycle;regulation of phosphorylation;response to drug","ATP binding;DNA helicase activity;single-stranded DNA binding","chromatin;cytosol;MCM complex;membrane;nuclear chromosome, telomeric region;nucleoplasm;nucleus","Cell cycle;DNA replication",null,null,14,14,14,25,25,25,"81.307",0,"71.054",902230000,42,"1.49876","0.321736","-0.69952","-5.48097","sp|P33993|MCM7_HUMAN;tr|C9J8M6|C9J8M6_HUMAN","sp|P33993|MCM7_HUMAN",914,"P33993","MCM7_HUMAN","DNA replication licensing factor MCM7",null,"MCM7"]
["23.3109","23.2202","24.0534","23.8771",{"$nulls":3},"positive regulation of cell proliferation","actin binding;calmodulin binding","cytoplasm;extracellular exosome;plasma membrane","Fc gamma R-mediated phagocytosis;Leishmaniasis",null,null,4,4,4,"62.1","62.1","62.1","19.529",0,"84.084",737340000,31,"1.71014","0.339333","-0.699673","-7.05746","sp|P49006|MRP_HUMAN","sp|P49006|MRP_HUMAN",1065,"P49006","MRP_HUMAN","MARCKS-related protein",null,"MARCKSL1"]
["17.5183","17.5014","18.3225","18.0978",{"$nulls":3},"activation of protein kinase activity;cellular response to extracellular stimulus;estrous cycle;negative regulation of gene expression;negative regulation of neuron apoptotic process;negative regulation of protein binding;negative regulation of synaptic transmission;nitric oxide homeostasis;positive regulation of axon extension;positive regulation of cGMP biosynthetic process;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of synapse assembly;regulation of protein ADP-ribosylation;regulation of transcription, DNA-templated;response to carbohydrate;response to inorganic substance;short-term memory;transcription, DNA-templated","beta-tubulin binding;chromatin binding;copper ion binding;DNA binding;peptide binding","axon;cytoplasm;dendrite;extracellular space;neuronal cell body;nucleus",{"$nulls":3},5,5,5,7,7,7,"123.56",0,"70.451",129440000,19,"1.60366","0.334367","-0.700338","-6.21721","sp|Q9H2P0|ADNP_HUMAN","sp|Q9H2P0|ADNP_HUMAN",2580,"Q9H2P0","ADNP_HUMAN","Activity-dependent neuroprotector homeobox protein",null,"ADNP"]
["17.115","17.4865","18.4931","17.5106",{"$nulls":9},2,2,2,17,17,17,"23.822",0,"6.9544",14208000,3,"0.503641","0.513075","-0.701097","-1.33487","tr|Q5TBQ1|Q5TBQ1_HUMAN;tr|Q5TBQ0|Q5TBQ0_HUMAN;sp|Q9BX40|LS14B_HUMAN;tr|A0A0C4DFV2|A0A0C4DFV2_HUMAN;tr|Q5TBP9|Q5TBP9_HUMAN","tr|Q5TBQ1|Q5TBQ1_HUMAN;tr|Q5TBQ0|Q5TBQ0_HUMAN;sp|Q9BX40|LS14B_HUMAN;tr|A0A0C4DFV2|A0A0C4DFV2_HUMAN;tr|Q5TBP9|Q5TBP9_HUMAN",2490,"Q5TBQ1","Q5TBQ1_HUMAN",null,null,"LSM14B"]
["18.2358","18.9579","19.6432","18.9532",{"$nulls":3},"actin cytoskeleton organization;actin filament organization;calcium ion transport;cell-substrate adhesion;cellular response to interleukin-4;early endosome to recycling endosome transport;homeostasis of number of cells within a tissue;innate immune response;leukocyte chemotaxis;movement of cell or subcellular component;natural killer cell degranulation;negative regulation of actin nucleation;negative regulation of neuron apoptotic process;negative regulation of vesicle fusion;nerve growth factor signaling pathway;phagocytosis;phagolysosome assembly;positive chemotaxis;positive regulation of cell migration;positive regulation of T cell proliferation;regulation of actin cytoskeleton organization;regulation of cell shape;regulation of release of sequestered calcium ion into cytosol;T cell homeostasis;uropod organization","actin binding;actin filament binding;actin monomer binding;cytoskeletal protein binding;myosin heavy chain binding;phosphatidylinositol 3-kinase binding;protein C-terminus binding;protein homodimerization activity;RNA binding","actin filament;axon;cell-cell junction;cortical actin cytoskeleton;cytoplasm;cytosol;early endosome;extracellular exosome;immunological synapse;lamellipodium;membrane;phagocytic cup;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane;protein complex","Phagosome;Tuberculosis",null,null,1,1,1,"3.5","3.5","3.5","51.026",0,"40.327",84636000,9,"0.529676","0.498615","-0.701329","-1.40447","sp|P31146|COR1A_HUMAN","sp|P31146|COR1A_HUMAN",882,"P31146","COR1A_HUMAN","Coronin-1A",null,"CORO1A"]
["14.6816","14.2827","15.2145","15.1531",{"$nulls":3},"endocytosis;endosomal vesicle fusion;endosome localization;Golgi to lysosome transport;positive regulation of pinocytosis;retrograde transport, endosome to Golgi","metal ion binding;phosphatidylinositol phosphate binding;Rab GTPase binding","cytosol;early endosome;endosome;endosome membrane;extracellular exosome;intracellular membrane-bounded organelle;lysosomal membrane;macropinosome;membrane",{"$nulls":3},1,1,1,"2.5","2.5","2.5","128.4",0,"44.913",21147000,5,"1.13259","0.312604","-0.701657","-3.477","sp|Q9P2R3|ANFY1_HUMAN","sp|Q9P2R3|ANFY1_HUMAN",2792,"Q9P2R3","ANFY1_HUMAN","Rabankyrin-5 {ECO:0000303|PubMed:15328530}","ank-5 {ECO:0000303|PubMed:22284051}","ANKFY1"]
["15.5831","15.3479","16.5492","15.7874",{"$nulls":3},"defense response to virus;exocyst localization;exocytosis;Golgi to plasma membrane transport;phosphatidylinositol-mediated signaling;positive regulation of protein secretion;protein transport;regulation of macroautophagy;viral process","GTP-Rho binding;phosphatidylinositol-4,5-bisphosphate binding","cytoplasm;cytoplasmic side of apical plasma membrane;cytosol;exocyst;Flemming body;membrane;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},3,3,3,"5.5","5.5","5.5","101.98",0,"5.0751",78631000,7,"0.657633","0.390349","-0.702768","-1.7629","sp|Q9NV70|EXOC1_HUMAN","sp|Q9NV70|EXOC1_HUMAN",2717,"Q9NV70","EXOC1_HUMAN","Exocyst complex component 1",null,"EXOC1"]
["19.2635","18.9817","19.9095","19.7419",{"$nulls":3},"post-translational protein modification","transcription factor binding;ubiquitin binding;ubiquitin protein ligase binding","cytosol;nuclear body;nucleoplasm;VCP-NPL4-UFD1 AAA ATPase complex",{"$nulls":3},3,3,3,"8.6","8.6","8.6","54.862",0,"35.035",141350000,11,"1.29854","0.331726","-0.70312","-4.28935","sp|O94888|UBXN7_HUMAN;tr|F8WB69|F8WB69_HUMAN;tr|C9JD50|C9JD50_HUMAN;tr|C9JAT7|C9JAT7_HUMAN","sp|O94888|UBXN7_HUMAN",397,"O94888","UBXN7_HUMAN","UBX domain-containing protein 7",null,"UBXN7"]
["21.8605","21.2421","22.4602","22.0543",{"$nulls":9},8,8,8,"38.8","38.8","38.8","31.703",0,"38.353",516680000,27,"0.706684","0.363282","-0.705953","-1.90895","tr|J3QT28|J3QT28_HUMAN;sp|O43684|BUB3_HUMAN;tr|J3QSX4|J3QSX4_HUMAN","tr|J3QT28|J3QT28_HUMAN;sp|O43684|BUB3_HUMAN;tr|J3QSX4|J3QSX4_HUMAN",258,"J3QT28","J3QT28_HUMAN",null,null,"BUB3"]
["15.9738","17.6144","17.7918","17.2086",{"$nulls":3},"cellular protein complex assembly;cellular response to misfolded protein;chaperone cofactor-dependent protein refolding;chaperone mediated protein folding requiring cofactor;ERAD pathway","Hsp70 protein binding","endoplasmic reticulum;integral component of endoplasmic reticulum membrane;membrane;nuclear membrane","Protein processing in endoplasmic reticulum",null,null,3,3,3,"13.9","13.9","13.9","41.818",0,"31.616",46102000,13,"0.29885","0.730793","-0.706057","-0.811032","sp|Q9NXW2|DJB12_HUMAN;tr|J3KPS0|J3KPS0_HUMAN;tr|V9GYN7|V9GYN7_HUMAN","sp|Q9NXW2|DJB12_HUMAN;tr|J3KPS0|J3KPS0_HUMAN",2743,"Q9NXW2","DJB12_HUMAN","DnaJ homolog subfamily B member 12 {ECO:0000312|HGNC:HGNC:14891}",null,"DNAJB12"]
["16.9833","17.3097","19.3086","16.3986",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination",null,"mitochondrial inner membrane;mitochondrial small ribosomal subunit","Ribosome",null,null,2,2,2,"14.4","14.4","14.4","22.999",0,"7.2101",29650000,5,"0.169527","0.851432","-0.707106","-0.482963","sp|P82664|RT10_HUMAN","sp|P82664|RT10_HUMAN",1379,"P82664","RT10_HUMAN","28S ribosomal protein S10, mitochondrial","10mt;RP-S10","MRPS10"]
["17.7122","17.4893","18.5888","18.0295",{"$nulls":3},"CUT catabolic process;DNA deamination;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);isotype switching;nuclear polyadenylation-dependent rRNA catabolic process;nuclear polyadenylation-dependent tRNA catabolic process;nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';polyadenylation-dependent snoRNA 3'-end processing;positive regulation of isotype switching;regulation of mRNA stability;rRNA processing;U4 snRNA 3'-end processing","3'-5'-exoribonuclease activity;RNA binding","cytoplasm;cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);nuclear exosome (RNase complex);nucleolus;nucleoplasm;nucleus;transcriptionally active chromatin","RNA degradation",null,null,2,2,2,"21.1","21.1","21.1","29.572",0,"36.569",32101000,12,"0.845015","0.308791","-0.708357","-2.35311","sp|Q9NQT5|EXOS3_HUMAN","sp|Q9NQT5|EXOS3_HUMAN",2671,"Q9NQT5","EXOS3_HUMAN","Exosome complex component RRP40",null,"EXOSC3"]
["17.6676","17.557","18.5544","18.0874",{"$nulls":3},"attachment of mitotic spindle microtubules to kinetochore;cell division;mitotic cell cycle checkpoint;mitotic spindle assembly checkpoint;negative regulation of T cell proliferation;regulation of metaphase plate congression;sister chromatid cohesion;thymus development","identical protein binding;kinetochore binding","actin cytoskeleton;centrosome;condensed chromosome kinetochore;cytosol;kinetochore;mitotic spindle;nuclear envelope;nucleus;spindle;spindle pole","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Viral carcinogenesis",null,null,5,5,5,"11.1","11.1","11.1","83.066",0,"27.306",135650000,16,"1.00842","0.294432","-0.708613","-2.95321","sp|Q9Y6D9|MD1L1_HUMAN;tr|C9JPS1|C9JPS1_HUMAN;tr|C9JTA2|C9JTA2_HUMAN;tr|C9JP81|C9JP81_HUMAN;tr|C9J9H5|C9J9H5_HUMAN;tr|C9JX80|C9JX80_HUMAN;tr|C9JKI7|C9JKI7_HUMAN;tr|C9K086|C9K086_HUMAN","sp|Q9Y6D9|MD1L1_HUMAN",3047,"Q9Y6D9","MD1L1_HUMAN","Mitotic spindle assembly checkpoint protein MAD1",null,"MAD1L1"]
["21.6694","20.7247","22.0563","21.7559",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","protein homodimerization activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;nucleus;proteasome complex;proteasome regulatory particle;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,7,7,7,"27.5","27.5","27.5","37.025",0,"15.931",534190000,27,"0.539293","0.487417","-0.70904","-1.43043","sp|P51665|PSMD7_HUMAN;tr|H3BNT7|H3BNT7_HUMAN;tr|H3BTM8|H3BTM8_HUMAN;tr|H3BQV2|H3BQV2_HUMAN","sp|P51665|PSMD7_HUMAN;tr|H3BNT7|H3BNT7_HUMAN;tr|H3BTM8|H3BTM8_HUMAN",1145,"P51665","PSMD7_HUMAN","26S proteasome non-ATPase regulatory subunit 7",null,"PSMD7"]
["15.3205","15.1279","16.4991","15.3729",{"$nulls":4},"ATP binding;protein kinase activity",{"$nulls":4},1,1,1,"6.9","6.9","6.9","28.517","0.0007593","2.896",7602400,1,"0.469901","0.533408","-0.711816","-1.24601","tr|H7C071|H7C071_HUMAN;tr|A0A087WUR6|A0A087WUR6_HUMAN;sp|Q14012|KCC1A_HUMAN;sp|Q8IU85|KCC1D_HUMAN","tr|H7C071|H7C071_HUMAN;tr|A0A087WUR6|A0A087WUR6_HUMAN;sp|Q14012|KCC1A_HUMAN;sp|Q8IU85|KCC1D_HUMAN",1596,"H7C071","H7C071_HUMAN",null,null,"CAMK1"]
["19.0788","19.2438","20.8189","18.9311",{"$nulls":4},"RNA binding","cytosol;nucleoplasm",{"$nulls":3},3,3,1,"9.4","9.4","3.1","42.835",0,"18.478",88063000,8,"0.275821","0.754573","-0.713701","-0.75328","tr|F8W8I6|F8W8I6_HUMAN;sp|P31483|TIA1_HUMAN;tr|E5RGV5|E5RGV5_HUMAN;tr|E5RG67|E5RG67_HUMAN;tr|C9JTN7|C9JTN7_HUMAN;tr|A6NKZ9|A6NKZ9_HUMAN;tr|F8WE16|F8WE16_HUMAN;tr|E7ETJ9|E7ETJ9_HUMAN;tr|E7ETC0|E7ETC0_HUMAN;tr|H7BY49|H7BY49_HUMAN","tr|F8W8I6|F8W8I6_HUMAN;sp|P31483|TIA1_HUMAN;tr|E5RGV5|E5RGV5_HUMAN;tr|E5RG67|E5RG67_HUMAN;tr|C9JTN7|C9JTN7_HUMAN",887,"F8W8I6","F8W8I6_HUMAN",null,null,"TIA1"]
["19.9193","18.2887","21.2048","18.4308",{"$nulls":9},2,2,2,31,31,31,"9.1924",0,"9.0009",28966000,3,"0.154482","0.87177","-0.713783","-0.443647","tr|E9PQV9|E9PQV9_HUMAN;sp|Q9BTE7|DCNL5_HUMAN;tr|E9PLH8|E9PLH8_HUMAN;tr|E9PM78|E9PM78_HUMAN;tr|H0YD80|H0YD80_HUMAN;tr|E9PLS2|E9PLS2_HUMAN;tr|E9PM04|E9PM04_HUMAN;tr|H0YCN4|H0YCN4_HUMAN","tr|E9PQV9|E9PQV9_HUMAN;sp|Q9BTE7|DCNL5_HUMAN;tr|E9PLH8|E9PLH8_HUMAN;tr|E9PM78|E9PM78_HUMAN;tr|H0YD80|H0YD80_HUMAN;tr|E9PLS2|E9PLS2_HUMAN;tr|E9PM04|E9PM04_HUMAN;tr|H0YCN4|H0YCN4_HUMAN",2446,"E9PQV9","E9PQV9_HUMAN","DCN1-like protein {ECO:0000256|RuleBase:RU363131}",null,"DCUN1D5"]
["16.7108","16.0138","17.3442","16.8083",{"$nulls":9},7,7,7,"6.9","6.9","6.9","217.2",0,"21.269",127490000,26,"0.609348","0.42814","-0.713958","-1.62412","tr|A0A0C4DGZ0|A0A0C4DGZ0_HUMAN;sp|P24928|RPB1_HUMAN;tr|A0A087WWE2|A0A087WWE2_HUMAN","tr|A0A0C4DGZ0|A0A0C4DGZ0_HUMAN;sp|P24928|RPB1_HUMAN",792,"A0A0C4DGZ0"]
["22.694","22.4279","23.3292","23.2206",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},5,5,5,"35.5","35.5","35.5","22.975",0,"65.291",692780000,32,"1.41776","0.334192","-0.713963","-4.96763","tr|X1WI28|X1WI28_HUMAN;sp|P27635|RL10_HUMAN;tr|F8W7C6|F8W7C6_HUMAN;tr|A0A087WV22|A0A087WV22_HUMAN;tr|H7C123|H7C123_HUMAN;tr|H7C2C5|H7C2C5_HUMAN;sp|Q96L21|RL10L_HUMAN;tr|B8A6G2|B8A6G2_HUMAN;tr|A6QRI9|A6QRI9_HUMAN","tr|X1WI28|X1WI28_HUMAN;sp|P27635|RL10_HUMAN;tr|F8W7C6|F8W7C6_HUMAN;tr|A0A087WV22|A0A087WV22_HUMAN;tr|H7C123|H7C123_HUMAN;tr|H7C2C5|H7C2C5_HUMAN",823,"X1WI28","X1WI28_HUMAN",null,null,"RPL10"]
["17.847","17.902","18.7759","18.4018",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;NLS-bearing protein import into nucleus;nuclear pore organization;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of transcription, DNA-templated;tRNA export from nucleus;viral process;viral transcription","nucleocytoplasmic transporter activity;phospholipid binding;single-stranded DNA binding","host cell;nuclear envelope;nuclear lamina;nuclear membrane;nuclear pore central transport channel;nuclear pore nuclear basket;nucleoplasm;plasma membrane","RNA transport",null,null,1,1,1,4,4,4,"34.773","0.00040274","3.4095",42757000,8,"1.19761","0.325203","-0.714345","-3.77864","sp|Q8NFH5|NUP53_HUMAN","sp|Q8NFH5|NUP53_HUMAN",2095,"Q8NFH5","NUP53_HUMAN","Nucleoporin NUP53",null,"NUP35"]
["20.126","20.0956","21.0025","20.6501",{"$nulls":3},"axon guidance;cell adhesion;cell-cell signaling;embryonic pattern specification;ephrin receptor signaling pathway;neural crest cell migration;positive regulation of T cell proliferation;T cell costimulation","ephrin receptor binding","cytoplasm;extracellular exosome;integral component of plasma membrane;membrane raft;nucleus;plasma membrane;synapse","Axon guidance",null,null,6,6,5,"29.2","29.2","21.7","38.006",0,"18.379",266020000,25,"1.25167","0.324481","-0.715493","-4.04546","sp|P98172|EFNB1_HUMAN","sp|P98172|EFNB1_HUMAN",1395,"P98172","EFNB1_HUMAN","Ephrin-B1",null,"EFNB1"]
["17.9693","17.4268","18.72","18.1098",{"$nulls":3},"regulation of blood pressure;response to hypoxia","angiotensin type II receptor activity","cell cortex;cytoplasmic vesicle membrane;cytosol;endoplasmic reticulum membrane;Golgi membrane;integral component of membrane;intracellular membrane-bounded organelle;nucleoplasm;plasma membrane",{"$nulls":3},1,1,1,"13.8","13.8","13.8","17.419",0,"4.5691",21965000,8,"0.655254","0.390549","-0.716851","-1.75595","sp|Q6RW13|ATRAP_HUMAN","sp|Q6RW13|ATRAP_HUMAN",1900,"Q6RW13","ATRAP_HUMAN","Type-1 angiotensin II receptor-associated protein",null,"AGTRAP"]
["19.2319","19.4374","20.3046","19.7997",{"$nulls":3},"ATP-dependent chromatin remodeling;cell cycle;CENP-A containing nucleosome assembly;chromatin assembly;chromatin remodeling;DNA replication;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;negative regulation of cell proliferation;negative regulation of G0 to G1 transition;negative regulation of gene expression, epigenetic;regulation of cell cycle;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;response to growth hormone;transcription, DNA-templated","histone binding;histone deacetylase activity;histone deacetylase binding","CAF-1 complex;cytosol;ESC/E(Z) complex;nuclear chromatin;nucleoplasm;nucleus;NuRD complex;NURF complex;protein complex;Sin3 complex","Cellular senescence",null,null,6,4,4,"24.7","21.6","21.6","47.655",0,"4.0402",133810000,3,"0.924181","0.293654","-0.717524","-2.63244","sp|Q09028|RBBP4_HUMAN;tr|C9JPP3|C9JPP3_HUMAN;tr|H0YF10|H0YF10_HUMAN;tr|E9PND5|E9PND5_HUMAN;tr|E9PNS6|E9PNS6_HUMAN;tr|H0YEU5|H0YEU5_HUMAN;tr|H0YCT5|H0YCT5_HUMAN;tr|H0YDK2|H0YDK2_HUMAN","sp|Q09028|RBBP4_HUMAN",1481,"Q09028","RBBP4_HUMAN","Histone-binding protein RBBP4",null,"RBBP4"]
["24.1433","22.8824","24.4862","23.9755",{"$nulls":3},"G1/S transition of mitotic cell cycle;positive regulation of mitotic centrosome separation;protein import into nucleus;RNA export from nucleus;signal transduction;spindle organization;ubiquitin-dependent protein catabolic process;viral process","cadherin binding;GDP-dissociation inhibitor activity;GTPase activator activity;Ran GTPase binding","centrosome;cytoplasm;cytosol;nuclear envelope;nucleus","Human T-cell leukemia virus 1 infection;Viral carcinogenesis",null,null,5,5,5,"35.8","35.8","35.8","23.31",0,"31.134",1533800000,38,"0.395953","0.624128","-0.718023","-1.05561","sp|P43487|RANG_HUMAN;tr|F6WQW2|F6WQW2_HUMAN;tr|C9JXG8|C9JXG8_HUMAN;tr|C9JJ34|C9JJ34_HUMAN;tr|C9JDM3|C9JDM3_HUMAN;tr|C9JGV6|C9JGV6_HUMAN;tr|C9JIC6|C9JIC6_HUMAN;sp|Q9C010|IPKB_HUMAN;tr|Q5T0Z6|Q5T0Z6_HUMAN","sp|P43487|RANG_HUMAN;tr|F6WQW2|F6WQW2_HUMAN;tr|C9JXG8|C9JXG8_HUMAN;tr|C9JJ34|C9JJ34_HUMAN",1012,"P43487","RANG_HUMAN","Ran-specific GTPase-activating protein",null,"RANBP1"]
["16.1864","15.8077","16.8913","16.5396",{"$nulls":9},2,2,2,"7.6","7.6","7.6","55.671",0,"6.634",24431000,12,"0.963769","0.293839","-0.718396","-2.77999","sp|Q53LP3|SWAHC_HUMAN","sp|Q53LP3|SWAHC_HUMAN",1798,"Q53LP3","SWAHC_HUMAN","Ankyrin repeat domain-containing protein SOWAHC",null,"SOWAHC"]
["17.4625","17.412","18.4481","17.8632",{"$nulls":3},"activation of JUN kinase activity;B cell apoptotic process;B cell homeostasis;epithelial cell migration;histone H3-T11 phosphorylation;hyperosmotic response;negative regulation of B cell proliferation;negative regulation of protein kinase activity;peptidyl-serine phosphorylation;protein phosphorylation;regulation of cell motility;regulation of germinal center formation;regulation of immunoglobulin production;regulation of transcription from RNA polymerase II promoter;renal system process;signal transduction;spleen development;transcription, DNA-templated","androgen receptor binding;ATP binding;chromatin binding;GTP-Rho binding;histone binding;histone deacetylase binding;histone kinase activity (H3-T11 specific);ligand-dependent nuclear receptor transcription coactivator activity;protein kinase activity;protein kinase C activity;protein kinase C binding;protein serine/threonine kinase activity;Rac GTPase binding","cleavage furrow;cytoplasm;cytosol;endosome;midbody;nucleoplasm;nucleus;plasma membrane;protein complex","PI3K-Akt signaling pathway;Salmonella infection;Yersinia infection",null,null,5,5,5,"11.3","11.3","11.3","103.93",0,"17.582",107860000,20,"0.872356","0.303875","-0.718439","-2.44732","sp|Q16512|PKN1_HUMAN;tr|K7EN76|K7EN76_HUMAN;tr|K7EM57|K7EM57_HUMAN","sp|Q16512|PKN1_HUMAN",1736,"Q16512","PKN1_HUMAN","Serine/threonine-protein kinase N1",null,"PKN1"]
["19.2531","19.1002","20.0957","19.6955",{"$nulls":3},"apoptotic mitochondrial changes;ATP metabolic process;cellular respiration;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;reactive oxygen species metabolic process;regulation of mitochondrial membrane potential","2 iron, 2 sulfur cluster binding;4 iron, 4 sulfur cluster binding;electron transfer activity;iron-sulfur cluster binding;metal ion binding;NADH dehydrogenase (ubiquinone) activity","mitochondrial intermembrane space;mitochondrial matrix;mitochondrial respiratory chain complex I;mitochondrion;myelin sheath","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,11,11,11,"23.7","23.7","23.7","79.467",0,"31.158",253030000,29,"1.10521","0.308295","-0.718926","-3.35584","sp|P28331|NDUS1_HUMAN;tr|B4DJ81|B4DJ81_HUMAN;tr|C9JPQ5|C9JPQ5_HUMAN","sp|P28331|NDUS1_HUMAN;tr|B4DJ81|B4DJ81_HUMAN",837,"P28331","NDUS1_HUMAN","NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial",null,"NDUFS1"]
["19.9608","19.6792","20.9977","20.081",{"$nulls":4},"phospholipid transporter activity","intracellular",{"$nulls":3},3,3,3,"19.6","19.6","19.6","31.802",0,"198.18",193210000,19,"0.56483","0.468714","-0.7193","-1.50007","tr|F5GWE5|F5GWE5_HUMAN;sp|Q00169|PIPNA_HUMAN;tr|I3L471|I3L471_HUMAN;tr|I3L4U7|I3L4U7_HUMAN;tr|I3NI10|I3NI10_HUMAN;tr|I3L2X8|I3L2X8_HUMAN;tr|I3L4C0|I3L4C0_HUMAN;tr|I3L459|I3L459_HUMAN;tr|I3L4H1|I3L4H1_HUMAN","tr|F5GWE5|F5GWE5_HUMAN;sp|Q00169|PIPNA_HUMAN;tr|I3L471|I3L471_HUMAN;tr|I3L4U7|I3L4U7_HUMAN",1400,"F5GWE5","F5GWE5_HUMAN",null,null,"PITPNA"]
["17.8525","17.7593","18.7824","18.2707",{"$nulls":3},"axon extension;cellular response to insulin stimulus;cognition;dendrite extension;Fc-gamma receptor signaling pathway involved in phagocytosis;lamellipodium assembly;modification of synaptic structure;negative regulation of synaptic vesicle recycling;neutrophil degranulation;positive regulation of Arp2/3 complex-mediated actin nucleation;positive regulation of axon extension;positive regulation of dendrite development;positive regulation of neurotrophin TRK receptor signaling pathway;positive regulation of ruffle assembly;Rac protein signal transduction;regulation of cell shape;regulation of translation;response to electrical stimulus;ruffle organization;vascular endothelial growth factor receptor signaling pathway","actin filament binding;protein complex binding;Rac GTPase binding;RNA 7-methylguanosine cap binding","axonal growth cone;central region of growth cone;cytosol;dendritic growth cone;dendritic spine;excitatory synapse;extracellular exosome;extracellular region;filopodium tip;focal adhesion;lamellipodium;mRNA cap binding complex;neuron projection;neuronal cell body;perinuclear region of cytoplasm;peripheral region of growth cone;ruffle;SCAR complex;secretory granule lumen;specific granule lumen;terminal bouton;tertiary granule lumen","Regulation of actin cytoskeleton;RNA transport",null,null,5,5,5,"4.6","4.6","4.6","145.18",0,"20.474",201910000,12,"0.961412","0.293275","-0.720656","-2.77105","sp|Q7L576|CYFP1_HUMAN;tr|A0A0G2JR96|A0A0G2JR96_HUMAN;tr|A0A0G2JQT1|A0A0G2JQT1_HUMAN;tr|A0A0G2JRX2|A0A0G2JRX2_HUMAN;tr|A0A087WU52|A0A087WU52_HUMAN;tr|A0A0G2JRV9|A0A0G2JRV9_HUMAN;tr|A0A087WWL1|A0A087WWL1_HUMAN;tr|A0A0G2JQH3|A0A0G2JQH3_HUMAN;tr|A0A087WVZ5|A0A087WVZ5_HUMAN;tr|A0A087WVE1|A0A087WVE1_HUMAN;tr|A0A087WTQ3|A0A087WTQ3_HUMAN;tr|A0A087WWZ1|A0A087WWZ1_HUMAN;tr|H7C229|H7C229_HUMAN;tr|E7EVJ5|E7EVJ5_HUMAN;sp|Q96F07|CYFP2_HUMAN","sp|Q7L576|CYFP1_HUMAN;tr|A0A0G2JR96|A0A0G2JR96_HUMAN;tr|A0A0G2JQT1|A0A0G2JQT1_HUMAN",1933,"Q7L576","CYFP1_HUMAN","Cytoplasmic FMR1-interacting protein 1",null,"CYFIP1"]
["18.906","18.9959","19.9065","19.438",{"$nulls":4},"tRNA (guanine-N2-)-methyltransferase activity;tRNA binding",{"$nulls":4},3,3,3,"14.8","14.8","14.8","32.795",0,"31.411",95096000,19,"1.02606","0.298812","-0.721269","-3.02376","tr|K7EQQ8|K7EQQ8_HUMAN;sp|Q9NXH9|TRM1_HUMAN;tr|K7EQY6|K7EQY6_HUMAN;tr|K7ENI9|K7ENI9_HUMAN;tr|K7EQU7|K7EQU7_HUMAN;tr|K7EMZ2|K7EMZ2_HUMAN;tr|K7ERR5|K7ERR5_HUMAN","tr|K7EQQ8|K7EQQ8_HUMAN;sp|Q9NXH9|TRM1_HUMAN;tr|K7EQY6|K7EQY6_HUMAN;tr|K7ENI9|K7ENI9_HUMAN;tr|K7EQU7|K7EQU7_HUMAN",2740,"K7EQQ8","K7EQQ8_HUMAN",null,null,"TRMT1"]
["15.4694","15.6799","16.0435","16.549",{"$nulls":5},"cytosol;Golgi apparatus",{"$nulls":3},2,2,2,"2.7","2.7","2.7","138.86",0,"22.884",48103000,16,"0.924984","0.295478","-0.721585","-2.63538","tr|E3W994|E3W994_HUMAN;tr|J3KR49|J3KR49_HUMAN;sp|O75122|CLAP2_HUMAN;tr|E7ERI8|E7ERI8_HUMAN;tr|E7EW49|E7EW49_HUMAN;tr|H7C4X8|H7C4X8_HUMAN;tr|H7C5M8|H7C5M8_HUMAN","tr|E3W994|E3W994_HUMAN;tr|J3KR49|J3KR49_HUMAN;sp|O75122|CLAP2_HUMAN;tr|E7ERI8|E7ERI8_HUMAN;tr|E7EW49|E7EW49_HUMAN;tr|H7C4X8|H7C4X8_HUMAN;tr|H7C5M8|H7C5M8_HUMAN",319,"E3W994","E3W994_HUMAN",null,null,"CLASP2"]
["17.1132","17.4444","18.3133","17.6889",{"$nulls":3},"cellular response to retinoic acid;generation of catalytic spliceosome for second transesterification step;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;mRNA splicing, via spliceosome;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;Notch signaling pathway;positive regulation by host of viral transcription;positive regulation of histone H3-K4 methylation;positive regulation of mRNA splicing, via spliceosome;positive regulation of neurogenesis;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transforming growth factor beta receptor signaling pathway;positive regulation of vitamin D receptor signaling pathway;regulation of retinoic acid receptor signaling pathway;regulation of transcription from RNA polymerase II promoter;regulation of vitamin D receptor signaling pathway;retinoic acid receptor signaling pathway;transcription initiation from RNA polymerase II promoter;viral process","androgen receptor binding;enzyme binding;Notch binding;nuclear hormone receptor binding;retinoic acid receptor binding;RNA binding;SMAD binding;transcription coactivator activity;transcription corepressor activity;vitamin D receptor binding","catalytic step 2 spliceosome;nuclear body;nuclear matrix;nuclear speck;nucleoplasm;nucleus;post-mRNA release spliceosomal complex;spliceosomal complex","Epstein-Barr virus infection;Notch signaling pathway;Spliceosome;Viral carcinogenesis",null,null,3,3,3,"6.2","6.2","6.2","61.494",0,"6.4566",42300000,8,"0.750406","0.33933","-0.722311","-2.04387","sp|Q13573|SNW1_HUMAN;tr|G3V3A4|G3V3A4_HUMAN;tr|G3V4X8|G3V4X8_HUMAN","sp|Q13573|SNW1_HUMAN;tr|G3V3A4|G3V3A4_HUMAN;tr|G3V4X8|G3V4X8_HUMAN",1573,"Q13573","SNW1_HUMAN","SNW domain-containing protein 1",null,"SNW1"]
["15.8161","15.9314","16.8821","16.3102",{"$nulls":4},"ATP binding","cytosol;nucleoplasm",{"$nulls":3},4,4,4,"6.1","6.1","6.1","107.43",0,"16.343",33960000,9,"0.880605","0.301894","-0.722382","-2.4762","tr|E7EXA6|E7EXA6_HUMAN;sp|Q8WVB6|CTF18_HUMAN;tr|A0A0D9SF58|A0A0D9SF58_HUMAN;tr|F8WCC1|F8WCC1_HUMAN","tr|E7EXA6|E7EXA6_HUMAN;sp|Q8WVB6|CTF18_HUMAN;tr|A0A0D9SF58|A0A0D9SF58_HUMAN",2143,"E7EXA6","E7EXA6_HUMAN",null,null,"CHTF18"]
["21.7712","21.3865","22.599","22.0035",{"$nulls":3},"gene silencing by RNA;mRNA polyadenylation;mRNA splicing, via spliceosome;mRNA stabilization;negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of viral genome replication;regulation of mRNA stability;translational initiation","mRNA 3'-UTR binding;poly(A) binding;poly(U) RNA binding;protein C-terminus binding;RNA binding;translation activator activity","catalytic step 2 spliceosome;cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleus","mRNA surveillance pathway;RNA degradation;RNA transport",null,null,22,22,14,"51.9","51.9","35.8","70.67",0,"192.05",1895900000,91,"0.748564","0.34032","-0.722404","-2.03809","sp|P11940|PABP1_HUMAN;tr|E7ERJ7|E7ERJ7_HUMAN;tr|E7EQV3|E7EQV3_HUMAN;tr|A0A087WTT1|A0A087WTT1_HUMAN;tr|H0YAR2|H0YAR2_HUMAN;tr|H0YBN4|H0YBN4_HUMAN;tr|E5RJB9|E5RJB9_HUMAN;sp|Q9H361|PABP3_HUMAN;tr|E5RGH3|E5RGH3_HUMAN;tr|E5RH24|E5RH24_HUMAN;tr|H0YAS6|H0YAS6_HUMAN;tr|H0YB75|H0YB75_HUMAN;tr|E5RHG7|E5RHG7_HUMAN;tr|B1ANR1|B1ANR1_HUMAN;tr|H0YAP2|H0YAP2_HUMAN;tr|H0YAS7|H0YAS7_HUMAN;tr|H0YB86|H0YB86_HUMAN;tr|H0YEQ8|H0YEQ8_HUMAN;tr|H0YAW6|H0YAW6_HUMAN;sp|Q4VXU2|PAP1L_HUMAN;tr|E5RGC4|E5RGC4_HUMAN;tr|E5RFD8|E5RFD8_HUMAN;tr|H0YCC8|H0YCC8_HUMAN;tr|E5RJM8|E5RJM8_HUMAN;tr|H0YC10|H0YC10_HUMAN;sp|Q5JQF8|PAP1M_HUMAN","sp|P11940|PABP1_HUMAN;tr|E7ERJ7|E7ERJ7_HUMAN;tr|E7EQV3|E7EQV3_HUMAN;tr|A0A087WTT1|A0A087WTT1_HUMAN",638,"P11940","PABP1_HUMAN","Polyadenylate-binding protein 1","ABP-1;oly(A)-binding protein 1","PABPC1"]
["17.1721","16.5293","18.1453","17.0044",{"$nulls":3},"apoptotic process;mRNA splicing, via spliceosome;RNA splicing, via transesterification reactions","RNA binding","Cajal body;cytoplasm;nuclear speck;nucleoplasm;nucleus;spliceosomal complex","Spliceosome",null,null,1,1,1,"11.3","11.3","11.3","26.711","0.00038835","3.1082",15274000,7,"0.41568","0.599238","-0.72414","-1.10591","sp|O75940|SPF30_HUMAN","sp|O75940|SPF30_HUMAN",378,"O75940","SPF30_HUMAN","Survival of motor neuron-related-splicing factor 30",null,"SMNDC1"]
["23.5258","23.1211","24.3391","23.7586",{"$nulls":3},"cell proliferation;neutrophil degranulation;signal transduction","RNA binding","extracellular region;ficolin-1-rich granule lumen",{"$nulls":3},6,6,6,"27.1","27.1","27.1","20.63",0,"13.865",1021100000,30,"0.752415","0.339452","-0.725425","-2.05019","sp|Q13442|HAP28_HUMAN;tr|F8WBW6|F8WBW6_HUMAN","sp|Q13442|HAP28_HUMAN",1556,"Q13442","HAP28_HUMAN","28 kDa heat- and acid-stable phosphoprotein",null,"PDAP1"]
["26.4552","25.8513","27.051","26.7073",{"$nulls":3},"actin cytoskeleton organization;actin filament depolymerization;actin filament fragmentation;cytoskeleton organization;establishment of cell polarity;interleukin-12-mediated signaling pathway;mitotic cytokinesis;negative regulation of apoptotic process;neural crest cell migration;neural fold formation;positive regulation by host of viral process;positive regulation of actin filament depolymerization;protein phosphorylation;regulation of cell morphogenesis;regulation of dendritic spine morphogenesis;response to amino acid;response to virus;Rho protein signal transduction","actin filament binding;receptor binding","cell-cell junction;cortical actin cytoskeleton;cytoplasm;cytosol;extracellular exosome;extracellular matrix;extracellular space;focal adhesion;lamellipodium;lamellipodium membrane;membrane;nuclear matrix;nucleus;ruffle membrane;vesicle","Axon guidance;Fc gamma R-mediated phagocytosis;Human immunodeficiency virus 1 infection;Pertussis;Regulation of actin cytoskeleton",null,null,10,10,7,"63.3","63.3","46.4","18.502",0,"176.26",9837300000,95,"0.764783","0.337074","-0.72588","-2.08929","sp|P23528|COF1_HUMAN;tr|G3V1A4|G3V1A4_HUMAN;tr|E9PK25|E9PK25_HUMAN;tr|E9PP50|E9PP50_HUMAN;tr|E9PQB7|E9PQB7_HUMAN;tr|E9PLJ3|E9PLJ3_HUMAN;tr|E9PS23|E9PS23_HUMAN","sp|P23528|COF1_HUMAN;tr|G3V1A4|G3V1A4_HUMAN;tr|E9PK25|E9PK25_HUMAN;tr|E9PP50|E9PP50_HUMAN;tr|E9PQB7|E9PQB7_HUMAN",783,"P23528","COF1_HUMAN","Cofilin-1",null,"CFL1"]
["16.5615","15.8087","17.3426","16.4846",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;endosome to melanosome transport;eye development;melanosome organization;melanosome transport;neuron projection development;pigmentation;platelet activation;platelet dense granule organization",null,"axon cytoplasm;BLOC-1 complex;cytosol;transport vesicle",{"$nulls":3},1,1,1,"9.4","9.4","9.4","21.255",0,"4.3596",10087000,3,"0.481515","0.52467","-0.7285","-1.27644","sp|Q6QNY0|BL1S3_HUMAN","sp|Q6QNY0|BL1S3_HUMAN",1899,"Q6QNY0","BL1S3_HUMAN","Biogenesis of lysosome-related organelles complex 1 subunit 3","LOC-1 subunit 3","BLOC1S3"]
["20.5746","20.5735","21.4698","21.1383",{"$nulls":3},"creatine metabolic process;muscle contraction","ATP binding;creatine kinase activity","mitochondrial inner membrane;mitochondrion","Arginine and proline metabolism;Metabolic pathways",null,null,5,5,4,15,15,"11.2","47.504",0,"209.61",327080000,40,"1.31993","0.331486","-0.730034","-4.40477","sp|P17540|KCRS_HUMAN","sp|P17540|KCRS_HUMAN",707,"P17540","KCRS_HUMAN","Creatine kinase S-type, mitochondrial",null,"CKMT2"]
["17.5945","17.7284","18.9169","17.8694",{"$nulls":3},"cell redox homeostasis;cellular copper ion homeostasis;copper ion transport;eye development;oxidation-reduction process;respiratory chain complex IV assembly","copper ion binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrion;myofibril","Central carbon metabolism in cancer",null,null,2,2,2,18,18,18,"29.81",0,"5.6242",38237000,10,"0.522691","0.502071","-0.731688","-1.3857","sp|O43819|SCO2_HUMAN;tr|C9JBU1|C9JBU1_HUMAN","sp|O43819|SCO2_HUMAN;tr|C9JBU1|C9JBU1_HUMAN",269,"O43819","SCO2_HUMAN","Protein SCO2 homolog, mitochondrial",null,"SCO2"]
["17.9334","18.156","18.8575","18.6957",{"$nulls":9},1,1,1,10,10,10,"19.359",0,"3.6461",39519000,3,"1.47415","0.324754","-0.731902","-5.32017","tr|M0R2S3|M0R2S3_HUMAN;sp|Q9BW85|CCD94_HUMAN","tr|M0R2S3|M0R2S3_HUMAN;sp|Q9BW85|CCD94_HUMAN",2481,"M0R2S3","M0R2S3_HUMAN",null,null,"CCDC94"]
["21.1108","24.659","22.2951","24.9389",{"$nulls":3},"ERBB2 signaling pathway;positive regulation of mitophagy in response to mitochondrial depolarization;posttranscriptional regulation of gene expression;protein folding;protein stabilization;protein targeting;regulation of cyclin-dependent protein serine/threonine kinase activity;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway","chaperone binding;heat shock protein binding;Hsp90 protein binding;kinase binding;protein kinase binding;protein kinase regulator activity;protein tyrosine kinase activity;unfolded protein binding","cytoplasm;cytosol;extracellular exosome;HSP90-CDC37 chaperone complex","PI3K-Akt signaling pathway",null,null,6,6,6,"18.8","18.8","18.8","44.468",0,"130.06",2132600000,30,"0.112293","0.904958","-0.732135","-0.330918","sp|Q16543|CDC37_HUMAN;tr|K7EQA9|K7EQA9_HUMAN;tr|K7EKQ2|K7EKQ2_HUMAN;tr|K7EL68|K7EL68_HUMAN;tr|K7EIU0|K7EIU0_HUMAN","sp|Q16543|CDC37_HUMAN;tr|K7EQA9|K7EQA9_HUMAN;tr|K7EKQ2|K7EKQ2_HUMAN",1742,"Q16543","CDC37_HUMAN","Hsp90 co-chaperone Cdc37",null,"CDC37"]
["20.4864","20.5104","21.2855","21.176",{"$nulls":9},1,1,1,"33.3","33.3","33.3","4.0925",0,"4.9244",31722000,4,"2.23632","0.440967","-0.732388","-13.0696","tr|F8VSD9|F8VSD9_HUMAN;tr|H0YHX0|H0YHX0_HUMAN;sp|Q9UBP6|TRMB_HUMAN","tr|F8VSD9|F8VSD9_HUMAN;tr|H0YHX0|H0YHX0_HUMAN;sp|Q9UBP6|TRMB_HUMAN",2805,"F8VSD9","F8VSD9_HUMAN",null,null,"METTL1"]
["17.1395","16.9552","18.0916","17.468",{"$nulls":9},2,2,2,"27.4","27.4","27.4","12.33",0,"4.1078",17315000,2,"0.815201","0.321841","-0.732458","-2.25295","tr|I3L328|I3L328_HUMAN;tr|G5EA36|G5EA36_HUMAN;sp|P30260|CDC27_HUMAN","tr|I3L328|I3L328_HUMAN;tr|G5EA36|G5EA36_HUMAN;sp|P30260|CDC27_HUMAN",868,"I3L328","I3L328_HUMAN",null,null,"CDC27"]
["23.9175","24.3691","25.1475","24.6042",{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;RNA metabolic process;viral RNA genome replication","cadherin binding;mRNA binding;RNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific single stranded DNA binding;single-stranded DNA binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;extracellular exosome;membrane;nuclear speck;nucleoplasm","Ferroptosis;Spliceosome",null,null,12,12,8,"49.7","49.7","36.5","37.497",0,"174.14",4128600000,86,"0.759893","0.337772","-0.732548","-2.07378","sp|Q15365|PCBP1_HUMAN;tr|F8VTZ0|F8VTZ0_HUMAN;tr|H3BSP4|H3BSP4_HUMAN;tr|C9K0A2|C9K0A2_HUMAN;tr|F8WC71|F8WC71_HUMAN;tr|C9IZV9|C9IZV9_HUMAN;tr|C9J7A9|C9J7A9_HUMAN;tr|C9JSA6|C9JSA6_HUMAN;tr|C9J5V4|C9J5V4_HUMAN;tr|C9JTY5|C9JTY5_HUMAN;tr|C9JZY3|C9JZY3_HUMAN;tr|C9J0A4|C9J0A4_HUMAN;tr|F6TJN8|F6TJN8_HUMAN;sp|P57723|PCBP4_HUMAN","sp|Q15365|PCBP1_HUMAN",1694,"Q15365","PCBP1_HUMAN","Poly(rC)-binding protein 1",null,"PCBP1"]
["17.4502","17.6224","18.0357","18.503",{"$nulls":3},"cellular protein metabolic process;post-translational protein modification;regulation of protein targeting;response to cisplatin","calcium ion binding;DNA binding;G-protein alpha-subunit binding","cis-Golgi network;early endosome;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular space;extrinsic component of Golgi membrane;Golgi cisterna membrane;Golgi-associated vesicle;lumenal side of Golgi membrane;membrane;nucleus;rough endoplasmic reticulum;trans-Golgi network",{"$nulls":3},3,3,3,"6.7","6.7","6.7","53.879","0.0011062","2.7054",63928000,2,"1.00601","0.294351","-0.733012","-2.9437","sp|Q02818|NUCB1_HUMAN;tr|C9JKZ2|C9JKZ2_HUMAN;tr|H7BZI1|H7BZI1_HUMAN;tr|C9JBD3|C9JBD3_HUMAN;tr|C9J3C1|C9J3C1_HUMAN","sp|Q02818|NUCB1_HUMAN;tr|C9JKZ2|C9JKZ2_HUMAN;tr|H7BZI1|H7BZI1_HUMAN",1433,"Q02818","NUCB1_HUMAN","Nucleobindin-1",null,"NUCB1"]
["17.6559","17.9281","18.9597","18.0907",{"$nulls":3},"positive regulation of NF-kappaB transcription factor activity","DNA binding;DNA binding transcription factor activity","cytosol;NF-kappaB complex;nucleus",{"$nulls":3},3,3,3,"13.3","13.3","13.3","42.868",0,"6.9501",84040000,16,"0.604477","0.430952","-0.733211","-1.61037","tr|Q2TAM5|Q2TAM5_HUMAN;tr|A0A087X0W8|A0A087X0W8_HUMAN;sp|Q04206|TF65_HUMAN;tr|E9PI38|E9PI38_HUMAN;tr|E9PQS6|E9PQS6_HUMAN;tr|E9PKV4|E9PKV4_HUMAN;tr|A0A087WVP0|A0A087WVP0_HUMAN;tr|E9PKH5|E9PKH5_HUMAN;tr|E9PJR1|E9PJR1_HUMAN;tr|E9PRX2|E9PRX2_HUMAN;tr|E9PNV4|E9PNV4_HUMAN;tr|E9PMD5|E9PMD5_HUMAN","tr|Q2TAM5|Q2TAM5_HUMAN;tr|A0A087X0W8|A0A087X0W8_HUMAN;sp|Q04206|TF65_HUMAN;tr|E9PI38|E9PI38_HUMAN;tr|E9PQS6|E9PQS6_HUMAN;tr|E9PKV4|E9PKV4_HUMAN;tr|A0A087WVP0|A0A087WVP0_HUMAN;tr|E9PKH5|E9PKH5_HUMAN",1440,"Q2TAM5","Q2TAM5_HUMAN"]
["16.4651","14.5919","17.531","14.9932",{"$nulls":3},"cytokine production;excretion;positive regulation of transcription from RNA polymerase II promoter;regulation of calcineurin-NFAT signaling cascade;signal transduction;transcription from RNA polymerase II promoter","DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytosol;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"1.9","1.9","1.9","165.76",0,"4.0464",17812000,2,"0.162684","0.862731","-0.733569","-0.46513","sp|O94916|NFAT5_HUMAN","sp|O94916|NFAT5_HUMAN",400,"O94916","NFAT5_HUMAN","Nuclear factor of activated T-cells 5","F-AT5","NFAT5"]
["20.1145","20.4022","21.4754","20.5084",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"14.6","14.6","14.6","8.8893","0.0020957","2.235",45249000,1,"0.54807","0.484325","-0.73357","-1.45425","tr|H0YFP7|H0YFP7_HUMAN;tr|H0YH69|H0YH69_HUMAN;sp|Q9HBU6|EKI1_HUMAN","tr|H0YFP7|H0YFP7_HUMAN;tr|H0YH69|H0YH69_HUMAN;sp|Q9HBU6|EKI1_HUMAN",2638,"H0YFP7","H0YFP7_HUMAN",null,null,"ETNK1"]
["15.5513","15.3493","16.5864","15.7815",{"$nulls":3},"carboxylic acid metabolic process","cadherin binding;carboxy-lyase activity;pyridoxal phosphate binding","Golgi apparatus;intracellular membrane-bounded organelle",{"$nulls":3},1,1,1,"1.4","1.4","1.4","86.706","0.0027797","2.1924",27818000,1,"0.65939","0.390823","-0.733614","-1.76804","sp|Q6P996|PDXD1_HUMAN;tr|H3BND4|H3BND4_HUMAN","sp|Q6P996|PDXD1_HUMAN;tr|H3BND4|H3BND4_HUMAN",1889,"Q6P996","PDXD1_HUMAN","Pyridoxal-dependent decarboxylase domain-containing protein 1",null,"PDXDC1"]
["20.8672","20.3551","21.4925","21.1975",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;post-translational protein modification;protein transport","GDP binding;GTP binding;GTPase activity","cytosol;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;Golgi apparatus;Golgi membrane;lysosomal membrane;melanosome;nucleus","AMPK signaling pathway",null,null,4,4,4,"23.6","23.6","23.6","23.545",0,"9.6858",315860000,25,"0.882673","0.303202","-0.733871","-2.48348","sp|P61019|RAB2A_HUMAN;tr|E9PKL7|E9PKL7_HUMAN;tr|H7C125|H7C125_HUMAN;tr|Q5HYI5|Q5HYI5_HUMAN;sp|Q8WUD1|RAB2B_HUMAN","sp|P61019|RAB2A_HUMAN;tr|E9PKL7|E9PKL7_HUMAN",1252,"P61019","RAB2A_HUMAN","Ras-related protein Rab-2A",null,"RAB2A"]
["19.3515","18.4202","19.7077","19.5323",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},11,3,3,"22.1","5.5","5.5","67.97",0,"13.452",235870000,14,"0.582695","0.453906","-0.734165","-1.54943","tr|B1ANR0|B1ANR0_HUMAN;sp|Q13310|PABP4_HUMAN;tr|H0Y5F5|H0Y5F5_HUMAN;tr|H0YEU6|H0YEU6_HUMAN;tr|H0YER0|H0YER0_HUMAN;tr|H0Y6X6|H0Y6X6_HUMAN;sp|P0CB38|PAB4L_HUMAN","tr|B1ANR0|B1ANR0_HUMAN;sp|Q13310|PABP4_HUMAN;tr|H0Y5F5|H0Y5F5_HUMAN",1542,"B1ANR0","B1ANR0_HUMAN","Polyadenylate-binding protein {ECO:0000256|RuleBase:RU362004}","ABP {ECO:0000256|RuleBase:RU362004}"]
["14.4706","14.2508","15.8583","14.3344",{"$nulls":3},"activation of JUN kinase activity;intracellular signal transduction;protein phosphorylation;regulation of apoptotic process;regulation of mitotic cell cycle","ATP binding;MAP kinase kinase kinase kinase activity;protein kinase activity;protein serine/threonine kinase activity","cytoplasm",{"$nulls":3},1,1,1,"1.5","1.5","1.5","95.023","0.0010722","2.3924",14327000,4,"0.356429","0.67771","-0.735673","-0.955606","tr|A0A0A0MQR1|A0A0A0MQR1_HUMAN;sp|Q9Y4K4|M4K5_HUMAN","tr|A0A0A0MQR1|A0A0A0MQR1_HUMAN;sp|Q9Y4K4|M4K5_HUMAN",3002,"A0A0A0MQR1","M4K5_HUMAN","Mitogen-activated protein kinase kinase kinase kinase 5",null,"MAP4K5"]
["19.9806","19.8151","20.7152","20.5537",{"$nulls":3},"actin cytoskeleton organization;regulation of mitochondrial fission","actin binding;Rho GTPase binding","perinuclear region of cytoplasm",{"$nulls":3},14,14,14,"20.7","20.7","20.7","135.62",0,"185.86",922310000,78,"1.62413","0.328211","-0.736597","-6.37115","sp|Q27J81|INF2_HUMAN;tr|A0A0A0MQU1|A0A0A0MQU1_HUMAN","sp|Q27J81|INF2_HUMAN;tr|A0A0A0MQU1|A0A0A0MQU1_HUMAN",1765,"Q27J81","INF2_HUMAN","Inverted formin-2",null,"INF2"]
["16.5167","16.515","17.3307","17.1769",{"$nulls":3},"establishment of cell polarity;microtubule cytoskeleton organization","ATP binding;protein serine/threonine kinase activity",{"$nulls":4},2,2,2,"5.3","5.3","5.3","74.09",0,"12.085",47907000,17,"1.97109","0.403267","-0.737962","-9.59495","tr|A0A0A0MST9|A0A0A0MST9_HUMAN;tr|A0A0A0MSZ1|A0A0A0MSZ1_HUMAN;tr|A0A0A0MT23|A0A0A0MT23_HUMAN;sp|P27448|MARK3_HUMAN;tr|J3KNR0|J3KNR0_HUMAN;tr|H0YKP9|H0YKP9_HUMAN;tr|A2SY06|A2SY06_HUMAN;tr|H0YIY6|H0YIY6_HUMAN;tr|A0A0A0MQR8|A0A0A0MQR8_HUMAN","tr|A0A0A0MST9|A0A0A0MST9_HUMAN;tr|A0A0A0MSZ1|A0A0A0MSZ1_HUMAN;tr|A0A0A0MT23|A0A0A0MT23_HUMAN;sp|P27448|MARK3_HUMAN;tr|J3KNR0|J3KNR0_HUMAN;tr|H0YKP9|H0YKP9_HUMAN;tr|A2SY06|A2SY06_HUMAN;tr|H0YIY6|H0YIY6_HUMAN;tr|A0A0A0MQR8|A0A0A0MQR8_HUMAN",822,"A0A0A0MST9","A0A0A0MST9_HUMAN","Non-specific serine/threonine protein kinase {ECO:0000256|SAAS:SAAS00804148}"]
["20.6327","20.3779","21.4999","20.9884",{"$nulls":3},"activation of innate immune response;B cell lineage commitment;brain development;cell proliferation;cellular protein modification process;cellular response to insulin stimulus;double-strand break repair;double-strand break repair via alternative nonhomologous end joining;double-strand break repair via nonhomologous end joining;ectopic germ cell programmed cell death;heart development;immunoglobulin V(D)J recombination;innate immune response;intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of apoptotic process;negative regulation of cellular senescence;negative regulation of immunoglobulin production;negative regulation of protein phosphorylation;negative regulation of response to gamma radiation;peptidyl-serine phosphorylation;positive regulation of apoptotic process;positive regulation of developmental growth;positive regulation of fibroblast proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;pro-B cell differentiation;protein destabilization;protein phosphorylation;protein ubiquitination;regulation of circadian rhythm;regulation of smooth muscle cell proliferation;response to activity;response to gamma radiation;rhythmic process;signal transduction involved in mitotic G1 DNA damage checkpoint;somitogenesis;spleen development;T cell differentiation in thymus;T cell lineage commitment;T cell receptor V(D)J recombination;telomere capping;thymus development","ATP binding;DNA-dependent protein kinase activity;double-stranded DNA binding;enzyme binding;protein domain specific binding;protein kinase activity;protein serine/threonine kinase activity;RNA binding;transcription factor binding","cytosol;DNA-dependent protein kinase-DNA ligase 4 complex;extracellular matrix;membrane;nonhomologous end joining complex;nuclear chromosome, telomeric region;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;transcription factor complex","Cell cycle;Non-homologous end-joining",null,null,63,63,63,"20.3","20.3","20.3","469.08",0,"323.31",4515400000,283,"0.911381","0.293374","-0.73886","-2.58589","sp|P78527|PRKDC_HUMAN;tr|H0YG84|H0YG84_HUMAN","sp|P78527|PRKDC_HUMAN",1373,"P78527","PRKDC_HUMAN","DNA-dependent protein kinase catalytic subunit","NA-PK catalytic subunit;NA-PKcs","PRKDC"]
["18.718","18.9646","19.9187","19.2423",{"$nulls":3},"pseudouridine synthesis;tRNA processing","enzyme binding;pseudouridine synthase activity;RNA binding","nucleus",{"$nulls":3},9,9,9,"23.1","23.1","23.1","75.035",0,"68.84",190700000,28,"0.753469","0.339082","-0.739215","-2.0535","sp|Q96PZ0|PUS7_HUMAN;tr|E7EUH7|E7EUH7_HUMAN;tr|H0Y863|H0Y863_HUMAN","sp|Q96PZ0|PUS7_HUMAN;tr|E7EUH7|E7EUH7_HUMAN",2335,"Q96PZ0","PUS7_HUMAN","Pseudouridylate synthase 7 homolog",null,"PUS7"]
["19.1747","18.3296","19.9122","19.0712",{"$nulls":3},"cyanate catabolic process;epithelial cell differentiation;rRNA import into mitochondrion;rRNA transport","5S rRNA binding;thiosulfate sulfurtransferase activity","extracellular exosome;extracellular space;mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Cysteine and methionine metabolism;Metabolic pathways;Sulfur metabolism;Sulfur relay system",null,null,3,3,3,"14.1","14.1","14.1","33.429",0,"6.1919",77804000,9,"0.467789","0.535456","-0.739506","-1.2405","sp|Q16762|THTR_HUMAN;tr|B1AH48|B1AH48_HUMAN","sp|Q16762|THTR_HUMAN",1753,"Q16762","THTR_HUMAN","Thiosulfate sulfurtransferase",null,"TST"]
["19.3493","19.3227","20.1788","19.9722",{"$nulls":9},1,1,1,"33.3","33.3","33.3","4.5243","0.001073","2.3924",20921000,4,"1.71558","0.34761","-0.739533","-7.10313","tr|H0Y8R8|H0Y8R8_HUMAN;tr|H0Y8Y6|H0Y8Y6_HUMAN;tr|H0Y9K2|H0Y9K2_HUMAN;sp|Q13535|ATR_HUMAN","tr|H0Y8R8|H0Y8R8_HUMAN;tr|H0Y8Y6|H0Y8Y6_HUMAN;tr|H0Y9K2|H0Y9K2_HUMAN;sp|Q13535|ATR_HUMAN",1567,"H0Y8R8","H0Y8R8_HUMAN",null,null,"ATR"]
["21.4186","21.7629","22.7999","21.8622",{"$nulls":3},"aspartyl-tRNA aminoacylation;protein complex assembly;translation;tRNA aminoacylation for protein translation","aminoacylase activity;aspartate-tRNA ligase activity;ATP binding;RNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;extracellular exosome;membrane","Aminoacyl-tRNA biosynthesis",null,null,15,15,15,"33.5","33.5","33.5","57.136",0,"95.065",1917400000,61,"0.558332","0.471003","-0.740264","-1.48225","sp|P14868|SYDC_HUMAN;tr|H7BZ35|H7BZ35_HUMAN;tr|C9J7S3|C9J7S3_HUMAN;tr|H7C278|H7C278_HUMAN;tr|C9JLC1|C9JLC1_HUMAN;tr|C9JQM9|C9JQM9_HUMAN","sp|P14868|SYDC_HUMAN",677,"P14868","SYDC_HUMAN","Aspartate--tRNA ligase, cytoplasmic",null,"DARS"]
["21.2422","21.1784","21.992","21.9097",{"$nulls":4},"DNA binding",{"$nulls":4},3,3,3,"40.2","40.2","40.2","10.004",0,"8.3909",230530000,14,"2.30937","0.446381","-0.740526","-14.226","tr|K7EQA1|K7EQA1_HUMAN;sp|O14737|PDCD5_HUMAN;tr|K7ESJ4|K7ESJ4_HUMAN","tr|K7EQA1|K7EQA1_HUMAN;sp|O14737|PDCD5_HUMAN",168,"K7EQA1","K7EQA1_HUMAN",null,null,"PDCD5"]
["19.1698","18.3815","19.41","19.6249",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleolus;nucleus","Ribosome",null,null,2,2,2,7,7,7,"29.842","0.0003879","3.1016",68274000,10,"0.675549","0.383138","-0.741796","-1.81563","sp|P82914|RT15_HUMAN","sp|P82914|RT15_HUMAN",1383,"P82914","RT15_HUMAN","28S ribosomal protein S15, mitochondrial","15mt;RP-S15","MRPS15"]
["22.2051","21.9185","22.9556","22.6541",{"$nulls":3},"binding of sperm to zona pellucida;chaperone-mediated protein folding;'de novo' protein folding;positive regulation of establishment of protein localization to telomere;positive regulation of protein localization to Cajal body;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;protein folding;protein stabilization;scaRNA localization to Cajal body;toxin transport","ATP binding;protein binding involved in protein folding;RNA binding;unfolded protein binding","cell body;cell projection;centrosome;chaperonin-containing T-complex;cytosol;extracellular exosome;melanosome;microtubule;nucleoplasm;zona pellucida receptor complex",{"$nulls":3},16,16,16,"44.5","44.5","44.5","57.924",0,"101.13",2178900000,98,"1.15352","0.309745","-0.743037","-3.57189","sp|P50991|TCPD_HUMAN","sp|P50991|TCPD_HUMAN",1125,"P50991","TCPD_HUMAN","T-complex protein 1 subunit delta","CP-1-delta","CCT4"]
["16.5371","15.9319","16.9276","17.0278",{"$nulls":4},"chloride channel activity","chloride channel complex;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;membrane;nucleus",{"$nulls":3},3,3,3,"8.9","8.9","8.9","62.022",0,"70.197",36729000,13,"0.8655","0.303433","-0.743213","-2.42348","sp|Q96S66|CLCC1_HUMAN","sp|Q96S66|CLCC1_HUMAN",2353,"Q96S66","CLCC1_HUMAN","Chloride channel CLIC-like protein 1",null,"CLCC1"]
["14.8952","13.8873","15.6741","14.5961",{"$nulls":3},"intra-Golgi vesicle-mediated transport",null,"Golgi apparatus;Golgi membrane;integral component of Golgi membrane;nucleoplasm",{"$nulls":3},3,3,1,"5.9","5.9","1.8","77.454",0,"8.1958",32072000,8,"0.377174","0.645834","-0.743784","-1.00798","sp|Q13948|CASP_HUMAN","sp|Q13948|CASP_HUMAN",1592,"Q13948","CASP_HUMAN","Protein CASP",null,"CUX1"]
["19.9713","19.8263","20.8468","20.4403",{"$nulls":3},"cellular amino acid biosynthetic process;citrulline biosynthetic process;glutamate metabolic process;L-proline biosynthetic process;ornithine biosynthetic process;proline biosynthetic process","ATP binding;delta1-pyrroline-5-carboxylate synthetase activity;glutamate 5-kinase activity;glutamate-5-semialdehyde dehydrogenase activity;identical protein binding;RNA binding","cytosol;mitochondrial inner membrane;mitochondrion","Arginine and proline metabolism;Biosynthesis of amino acids;Metabolic pathways",null,null,9,9,9,"16.4","16.4","16.4","87.301",0,"108.44",640540000,27,"1.12684","0.309333","-0.744786","-3.45128","sp|P54886|P5CS_HUMAN","sp|P54886|P5CS_HUMAN",1199,"P54886","P5CS_HUMAN","Delta-1-pyrroline-5-carboxylate synthase","5CS","ALDH18A1"]
["16.551","16.3309","17.5101","16.8623",{"$nulls":3},"cell division;mitotic chromosome condensation",null,"condensed chromosome, centromeric region;condensin complex;cytoplasm;cytosol;membrane;nucleus",{"$nulls":3},5,5,5,"8.6","8.6","8.6","114.33",0,"22.094",89082000,21,"0.792524","0.332677","-0.745274","-2.17847","sp|Q9BPX3|CND3_HUMAN;tr|D6RA93|D6RA93_HUMAN;tr|H0Y9Z8|H0Y9Z8_HUMAN","sp|Q9BPX3|CND3_HUMAN",2407,"Q9BPX3","CND3_HUMAN","Condensin complex subunit 3",null,"NCAPG"]
["21.7442","21.5996","22.5695","22.2652",{"$nulls":3},"mitochondrion transport along microtubule;mRNA transport;negative regulation of mitochondrial RNA catabolic process;regulation of mitochondrial translation;regulation of transcription, DNA-templated;RNA modification;transcription, DNA-templated","beta-tubulin binding;endonuclease activity;microtubule binding;RNA binding;single-stranded DNA binding;ubiquitin protein ligase binding","condensed nuclear chromosome;cytoskeleton;intracellular ribonucleoprotein complex;membrane;microtubule;mitochondrial nucleoid;mitochondrion;nuclear inner membrane;nuclear outer membrane;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},39,39,39,"38.7","38.7","38.7","157.9",0,"323.31",4277300000,207,"1.32385","0.331167","-0.745417","-4.4262","sp|P42704|LPPRC_HUMAN;tr|B8ZZ38|B8ZZ38_HUMAN;tr|A0A0C4DG06|A0A0C4DG06_HUMAN;tr|C9JCA9|C9JCA9_HUMAN;tr|H7C3W8|H7C3W8_HUMAN;tr|A0A0C4DG51|A0A0C4DG51_HUMAN;sp|Q9NP80|PLPL8_HUMAN","sp|P42704|LPPRC_HUMAN",997,"P42704","LPPRC_HUMAN","Leucine-rich PPR motif-containing protein, mitochondrial",null,"LRPPRC"]
["16.8411","15.964","17.4858","16.8101",{"$nulls":4},"ATP binding;protein kinase activity",{"$nulls":4},5,5,4,"6.4","6.4","5.4","144.92",0,"21.383",70888000,13,"0.508052","0.513801","-0.745453","-1.34659","tr|E7EN19|E7EN19_HUMAN;tr|E7ESS2|E7ESS2_HUMAN;tr|C9J840|C9J840_HUMAN;tr|E7EX83|E7EX83_HUMAN;tr|A0A0D9SG62|A0A0D9SG62_HUMAN;tr|E7ENQ1|E7ENQ1_HUMAN;tr|G3XAA2|G3XAA2_HUMAN;tr|H7C360|H7C360_HUMAN;tr|G5E948|G5E948_HUMAN;sp|O95819|M4K4_HUMAN;tr|A0A0D9SEY1|A0A0D9SEY1_HUMAN;tr|H7C0P6|H7C0P6_HUMAN","tr|E7EN19|E7EN19_HUMAN;tr|E7ESS2|E7ESS2_HUMAN;tr|C9J840|C9J840_HUMAN;tr|E7EX83|E7EX83_HUMAN;tr|A0A0D9SG62|A0A0D9SG62_HUMAN;tr|E7ENQ1|E7ENQ1_HUMAN;tr|G3XAA2|G3XAA2_HUMAN;tr|H7C360|H7C360_HUMAN;tr|G5E948|G5E948_HUMAN;sp|O95819|M4K4_HUMAN;tr|A0A0D9SEY1|A0A0D9SEY1_HUMAN;tr|H7C0P6|H7C0P6_HUMAN",3082,"E7EN19","E7EN19_HUMAN",null,null,"MAP4K4"]
["17.2975","17.7263","18.2472","18.2688",{"$nulls":5},"cytosol;nucleus;plasma membrane",{"$nulls":3},3,3,3,"17.1","17.1","17.1","34.496","0.00040258","3.409",38890000,4,"1.13216","0.311868","-0.746051","-3.47506","tr|F8VP97|F8VP97_HUMAN;tr|F8VV52|F8VV52_HUMAN;sp|Q9NZN8|CNOT2_HUMAN;tr|F8VQF4|F8VQF4_HUMAN;tr|F8VRS8|F8VRS8_HUMAN;tr|F8W145|F8W145_HUMAN;tr|F8VQD8|F8VQD8_HUMAN;tr|A0A087X050|A0A087X050_HUMAN;tr|F8VVY1|F8VVY1_HUMAN;tr|F8VUB4|F8VUB4_HUMAN;tr|F8VX63|F8VX63_HUMAN","tr|F8VP97|F8VP97_HUMAN;tr|F8VV52|F8VV52_HUMAN;sp|Q9NZN8|CNOT2_HUMAN;tr|F8VQF4|F8VQF4_HUMAN;tr|F8VRS8|F8VRS8_HUMAN;tr|F8W145|F8W145_HUMAN",2763,"F8VP97","F8VP97_HUMAN",null,null,"CNOT2"]
["18.2138","18.0933","19.3065","18.4992",{"$nulls":3},"peroxisome membrane biogenesis;peroxisome organization;protein import into peroxisome membrane;transmembrane transport","lipid binding;protein dimerization activity","cytosol;endoplasmic reticulum;integral component of peroxisomal membrane;membrane;nucleoplasm;peroxisomal membrane;peroxisome;protein complex;protein-lipid complex","Peroxisome",null,null,2,2,2,"7.5","7.5","7.5","42.139",0,"11.114",73618000,6,"0.682453","0.378008","-0.74933","-1.83613","sp|P56589|PEX3_HUMAN","sp|P56589|PEX3_HUMAN",1226,"P56589","PEX3_HUMAN","Peroxisomal biogenesis factor 3",null,"PEX3"]
["16.2266","15.8907","17.264","16.3542",{"$nulls":3},"actin cytoskeleton organization;lamellipodium assembly;movement of cell or subcellular component;regulation of Arp2/3 complex-mediated actin nucleation;ruffle organization;small GTPase mediated signal transduction","cadherin binding;GTP binding;GTP-dependent protein binding;identical protein binding;phosphatidylinositol-4-phosphate binding;protein domain specific binding;Rac GTPase binding","cell cortex;cytoplasm;cytosol;plasma membrane;ruffle;trans-Golgi network membrane",{"$nulls":3},1,1,1,"4.7","4.7","4.7","37.855",0,"5.6357",15506000,8,"0.582016","0.453504","-0.750438","-1.54754","sp|P53365|ARFP2_HUMAN;tr|A0A087X1E4|A0A087X1E4_HUMAN","sp|P53365|ARFP2_HUMAN;tr|A0A087X1E4|A0A087X1E4_HUMAN",1176,"P53365","ARFP2_HUMAN","Arfaptin-2",null,"ARFIP2"]
["13.5209","13.504","14.8566","13.6692",{"$nulls":3},"negative regulation of Ras protein signal transduction;signal transduction","GTPase activator activity",{"$nulls":4},1,1,1,"2.2","2.2","2.2","101.79","0.0075683","1.7531",6150600,1,"0.476776","0.528125","-0.750487","-1.264","tr|E9PGC0|E9PGC0_HUMAN;sp|P20936|RASA1_HUMAN","tr|E9PGC0|E9PGC0_HUMAN;sp|P20936|RASA1_HUMAN",749,"E9PGC0","E9PGC0_HUMAN",null,null,"RASA1"]
["19.7418","19.1684","20.3573","20.055",{"$nulls":3},"autophagosome maturation;autophagosome membrane docking;cilium assembly;exocytosis;membrane fusion;neutrophil degranulation;protein transport;synaptic vesicle fusion to presynaptic active zone membrane;synaptic vesicle priming;vesicle targeting","SNAP receptor activity;syntaxin binding","autophagosome;autophagosome membrane;azurophil granule membrane;centrosome;ciliary pocket membrane;cytoplasm;cytosol;Golgi membrane;nucleoplasm;plasma membrane;presynapse;SNARE complex","Autophagy - animal;SNARE interactions in vesicular transport",null,null,4,4,4,"22.1","22.1","22.1","28.97",0,"8.1585",121670000,16,"0.834445","0.313992","-0.751054","-2.3173","sp|O95721|SNP29_HUMAN;tr|C9JAF7|C9JAF7_HUMAN","sp|O95721|SNP29_HUMAN;tr|C9JAF7|C9JAF7_HUMAN",446,"O95721","SNP29_HUMAN","Synaptosomal-associated protein 29 {ECO:0000312|HGNC:HGNC:11133}","NAP-29 {ECO:0000312|HGNC:HGNC:11133}","SNAP29"]
["19.4495","19.3386","20.6586","19.6325",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},2,2,2,"12.6","12.6","12.6","24.354",0,"13.798",85581000,9,"0.548852","0.482144","-0.751506","-1.45638","tr|A0A0G2JIC6|A0A0G2JIC6_HUMAN;sp|Q9Y676|RT18B_HUMAN","tr|A0A0G2JIC6|A0A0G2JIC6_HUMAN;sp|Q9Y676|RT18B_HUMAN",3039,"A0A0G2JIC6","A0A0G2JIC6_HUMAN",null,null,"MRPS18B"]
["17.9831","16.9656","18.7865","17.6653",{"$nulls":3},"cell adhesion;cell-matrix adhesion;cellular response to reactive oxygen species;endothelial cell migration;epidermal growth factor receptor signaling pathway;growth hormone receptor signaling pathway;muscle contraction;positive regulation of stress fiber assembly;signal complex assembly;signal transduction;transforming growth factor beta receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway","beta-catenin binding;integrin binding;metal ion binding;neuropilin binding;protein kinase binding;ubiquitin protein ligase binding;vinculin binding","cell cortex;cytosol;focal adhesion;lamellipodium;microtubule associated complex;plasma membrane;stress fiber","Bacterial invasion of epithelial cells;Chemokine signaling pathway;Focal adhesion;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Leukocyte transendothelial migration;Proteoglycans in cancer;Regulation of actin cytoskeleton;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,4,4,4,"12.4","12.4","12.4","64.505",0,"21.596",97858000,20,"0.371144","0.655164","-0.751544","-0.992733","sp|P49023|PAXI_HUMAN;tr|F5GZ78|F5GZ78_HUMAN;tr|F5H836|F5H836_HUMAN;tr|H0YIE4|H0YIE4_HUMAN","sp|P49023|PAXI_HUMAN;tr|F5GZ78|F5GZ78_HUMAN;tr|F5H836|F5H836_HUMAN",1066,"P49023","PAXI_HUMAN","Paxillin",null,"PXN"]
["19.2108","19.1892","20.0856","19.8188",{"$nulls":3},"apoptotic DNA fragmentation;intracellular transport of virus;modulation by virus of host process;NLS-bearing protein import into nucleus;regulation of DNA recombination","nuclear localization sequence binding;protein transporter activity","cytoplasm;cytosol;dendrite;host cell;nuclear pore;nucleoplasm;nucleus","Influenza A",null,null,5,5,3,"14.3","14.3","8.9","60.221",0,"40.639",166630000,28,"1.51938","0.323877","-0.752213","-5.61906","sp|P52294|IMA5_HUMAN;tr|H0Y3K0|H0Y3K0_HUMAN;tr|C9J352|C9J352_HUMAN;tr|C9JWD9|C9JWD9_HUMAN;tr|F2Z3G4|F2Z3G4_HUMAN;tr|C9J4U1|C9J4U1_HUMAN;tr|C9JYI4|C9JYI4_HUMAN","sp|P52294|IMA5_HUMAN",1154,"P52294","IMA5_HUMAN","Importin subunit alpha-5",null,"KPNA1"]
["17.994",1,1,"19.4986",{"$nulls":3},"translation","structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;nucleus;plasma membrane","Ribosome",null,null,2,2,2,16,16,16,"12.469","0.0011211","2.7779",9721100,3,"0.018778","0.975409","-0.752311","-0.0598984","sp|Q969Q0|RL36L_HUMAN;sp|P83881|RL36A_HUMAN;tr|H0Y5B4|H0Y5B4_HUMAN;tr|H7BZ11|H7BZ11_HUMAN;tr|J3KQN4|J3KQN4_HUMAN","sp|Q969Q0|RL36L_HUMAN;sp|P83881|RL36A_HUMAN;tr|H0Y5B4|H0Y5B4_HUMAN;tr|H7BZ11|H7BZ11_HUMAN;tr|J3KQN4|J3KQN4_HUMAN",2220,"Q969Q0","RL36L_HUMAN","60S ribosomal protein L36a-like",null,"RPL36AL"]
["20.8653","20.3201","21.7302","20.9636",{"$nulls":9},1,1,1,"26.4","26.4","26.4","7.8269",0,"10.896",44946000,8,"0.602039","0.432955","-0.75416","-1.60351","tr|D6RE15|D6RE15_HUMAN;tr|D6RCC8|D6RCC8_HUMAN;sp|Q06203|PUR1_HUMAN","tr|D6RE15|D6RE15_HUMAN;tr|D6RCC8|D6RCC8_HUMAN;sp|Q06203|PUR1_HUMAN",1456,"D6RE15","D6RE15_HUMAN",null,null,"PPAT"]
["18.4117","18.1847","19.3802","18.7247",{"$nulls":3},"cellular response to amino acid starvation;cellular response to leucine starvation;positive regulation of kinase activity;positive regulation of transcription from RNA polymerase II promoter in response to stress;regulation of translation","cadherin binding;protein kinase binding;protein kinase regulator activity;ribosome binding;RNA binding;translation factor activity, RNA binding","cytoplasm;cytosol;membrane;polysome;ribosome",{"$nulls":3},26,26,26,"12.6","12.6","12.6","292.75",0,"118.34",755330000,91,"0.791321","0.332526","-0.754287","-2.17456","sp|Q92616|GCN1L_HUMAN","sp|Q92616|GCN1L_HUMAN",2179,"Q92616","GCN1_HUMAN","eIF-2-alpha kinase activator GCN1 {ECO:0000250|UniProtKB:E9PVA8}",null,"GCN1"]
["16.1873","16.2267","17.0182","16.905",{"$nulls":3},"mitotic cell cycle checkpoint;mRNA splicing, via spliceosome",null,"nuclear speck;nucleoplasm;nucleus","Renal cell carcinoma;Transcriptional misregulation in cancer",null,null,1,1,1,"4.3","4.3","4.3","52.417",0,"3.6025",14683000,7,"2.20416","0.431484","-0.754623","-12.5903","sp|Q92733|PRCC_HUMAN","sp|Q92733|PRCC_HUMAN",2187,"Q92733","PRCC_HUMAN","Proline-rich protein PRCC",null,"PRCC"]
["19.9604","18.6577","20.3884","19.7401",{"$nulls":3},"intracellular protein transport;pinocytosis;regulation of macroautophagy;retrograde transport, endosome to Golgi;vesicle organization","cadherin binding;dynactin binding;phosphatidylinositol binding;protein heterodimerization activity","cytoplasmic vesicle membrane;cytosol;early endosome membrane;extrinsic component of cytoplasmic side of plasma membrane;extrinsic component of endosome membrane;macropinocytic cup;phagocytic cup;retromer complex;retromer, tubulation complex;ruffle;tubular endosome","Endocytosis",null,null,6,6,6,"17.3","17.3","17.3","46.816",0,"30.367",256470000,28,"0.388999","0.634895","-0.755147","-1.03794","sp|Q9Y5X3|SNX5_HUMAN;tr|Q5QPE4|Q5QPE4_HUMAN;tr|A0A087WUY5|A0A087WUY5_HUMAN;tr|Q5QPE5|Q5QPE5_HUMAN;tr|U3KQL0|U3KQL0_HUMAN;tr|U3KQP5|U3KQP5_HUMAN","sp|Q9Y5X3|SNX5_HUMAN;tr|Q5QPE4|Q5QPE4_HUMAN;tr|A0A087WUY5|A0A087WUY5_HUMAN;tr|Q5QPE5|Q5QPE5_HUMAN",3031,"Q9Y5X3","SNX5_HUMAN","Sorting nexin-5",null,"SNX5"]
["17.8468","17.8036","18.6654","18.496",{"$nulls":3},"multicellular organism development;positive regulation of viral transcription;regulation of transcription, DNA-templated;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter",null,"cytosol;NELF complex;nuclear body;nucleoplasm",{"$nulls":3},3,3,3,"13.6","13.6","13.6","57.276",0,"8.6499",52540000,11,"1.88225","0.393169","-0.755476","-8.64607","sp|Q9H3P2|NELFA_HUMAN;tr|H0Y3X6|H0Y3X6_HUMAN;tr|A0A0C4DFX9|A0A0C4DFX9_HUMAN;tr|H7C2C7|H7C2C7_HUMAN","sp|Q9H3P2|NELFA_HUMAN;tr|H0Y3X6|H0Y3X6_HUMAN;tr|A0A0C4DFX9|A0A0C4DFX9_HUMAN",2589,"Q9H3P2","NELFA_HUMAN","Negative elongation factor A","ELF-A","NELFA"]
["19.0899","19.2155","20.156","19.6605",{"$nulls":3},"aggrephagy;apoptotic process;autophagy;autophagy of mitochondrion;cell differentiation;endosomal transport;endosome organization;immune system process;intracellular signal transduction;macroautophagy;mitophagy;negative regulation of apoptotic process;negative regulation of growth of symbiont in host;negative regulation of transcription from RNA polymerase II promoter;positive regulation of apoptotic process;positive regulation of long-term synaptic potentiation;positive regulation of protein localization to plasma membrane;positive regulation of protein phosphorylation;positive regulation of transcription from RNA polymerase II promoter;protein heterooligomerization;protein localization;protein localization to perinuclear region of cytoplasm;regulation of I-kappaB kinase/NF-kappaB signaling;regulation of mitochondrion organization;regulation of protein complex stability;regulation of Ras protein signal transduction;response to ischemia;response to mitochondrial depolarisation;response to stress;ubiquitin-dependent protein catabolic process","enzyme binding;identical protein binding;ionotropic glutamate receptor binding;K63-linked polyubiquitin modification-dependent protein binding;protein homodimerization activity;protein kinase binding;protein kinase C binding;protein serine/threonine kinase activity;receptor tyrosine kinase binding;SH2 domain binding;ubiquitin binding;ubiquitin protein ligase binding;zinc ion binding","aggresome;amphisome;autolysosome;autophagosome;cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;inclusion body;intracellular membrane-bounded organelle;late endosome;Lewy body;nucleoplasm;P-body;phagophore assembly site;PML body;sarcomere;sperm midpiece","Cellular senescence;Fluid shear stress and atherosclerosis;Mitophagy - animal;Necroptosis;Osteoclast differentiation",null,null,6,6,6,"24.1","24.1","24.1","47.687",0,"19.71",233100000,34,"1.00919","0.295505","-0.755561","-2.95628","sp|Q13501|SQSTM_HUMAN;tr|E7EMC7|E7EMC7_HUMAN;tr|E9PFW8|E9PFW8_HUMAN","sp|Q13501|SQSTM_HUMAN;tr|E7EMC7|E7EMC7_HUMAN",1563,"Q13501","SQSTM_HUMAN","Sequestosome-1",null,"SQSTM1"]
["21.6516","23.0734","23.2593","22.9799",{"$nulls":3},"cellular response to acidic pH;constitutive secretory pathway;establishment of protein localization to membrane;insulin secretion involved in cellular response to glucose stimulus;melanosome transport;post-translational protein modification;receptor recycling;regulated exocytosis;regulation of anion transport;regulation of endocytic recycling;regulation of protein localization to cell surface;retrograde transport, endosome to plasma membrane;transcytosis;transferrin transport","cadherin binding;GDP binding;GTP binding;GTPase activity;myosin V binding","anchored component of synaptic vesicle membrane;cell junction;cytosol;extracellular exosome;mitochondrion;phagocytic vesicle;phagocytic vesicle membrane;recycling endosome;recycling endosome membrane;synaptic vesicle","AMPK signaling pathway;Endocytosis;Influenza A;Vasopressin-regulated water reabsorption",null,null,8,8,8,"39.4","39.4","39.4","24.488",0,"316.27",1100400000,53,"0.391777","0.629951","-0.757094","-1.045","sp|Q15907|RB11B_HUMAN;tr|H3BMH2|H3BMH2_HUMAN;tr|H3BSC1|H3BSC1_HUMAN;sp|P62491|RB11A_HUMAN;tr|M0R2D0|M0R2D0_HUMAN;tr|B4DQU5|B4DQU5_HUMAN;sp|P57735|RAB25_HUMAN;tr|A0A0C4DGX5|A0A0C4DGX5_HUMAN","sp|Q15907|RB11B_HUMAN;tr|H3BMH2|H3BMH2_HUMAN;tr|H3BSC1|H3BSC1_HUMAN;sp|P62491|RB11A_HUMAN",1729,"Q15907","RB11B_HUMAN","Ras-related protein Rab-11B",null,"RAB11B"]
["19.2071","19.0935","20.0862","19.7287",{"$nulls":3},"cytoplasmic translational initiation;translational initiation","translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m",{"$nulls":3},5,5,5,"23.8","23.8","23.8","42.502",0,"110.43",190430000,29,"1.25015","0.322589","-0.75714","-4.03774","sp|Q7L2H7|EIF3M_HUMAN;tr|H0YCQ8|H0YCQ8_HUMAN;tr|E9PRI2|E9PRI2_HUMAN;tr|E7ESM3|E7ESM3_HUMAN;tr|J3KNJ2|J3KNJ2_HUMAN","sp|Q7L2H7|EIF3M_HUMAN;tr|H0YCQ8|H0YCQ8_HUMAN",1931,"Q7L2H7","EIF3M_HUMAN","Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012}","IF3m {ECO:0000255|HAMAP-Rule:MF_03012}","EIF3M"]
["19.7812","19.4507","20.5414","20.2048",{"$nulls":3},"bile acid biosynthetic process","cholesterol binding;sterol transporter activity","cytosol;endoplasmic reticulum membrane;filopodium tip;membrane;nuclear membrane;perinuclear endoplasmic reticulum;plasma membrane",{"$nulls":3},11,11,11,"17.6","17.6","17.6","101.22",0,"48.214",487610000,60,"1.07118","0.302744","-0.75714","-3.20986","sp|Q9H4L5|OSBL3_HUMAN;tr|C9J8P4|C9J8P4_HUMAN;tr|C9JEF2|C9JEF2_HUMAN;tr|C9JZ19|C9JZ19_HUMAN","sp|Q9H4L5|OSBL3_HUMAN",2599,"Q9H4L5","OSBL3_HUMAN","Oxysterol-binding protein-related protein 3","RP-3;SBP-related protein 3","OSBPL3"]
["22.0632","21.7278","23.1674","22.1383",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal large subunit assembly;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;rRNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane","Ribosome",null,null,4,4,4,"37.6","37.6","37.6","17.818",0,"22.374",454090000,19,"0.527847","0.498952","-0.757401","-1.39955","sp|P30050|RL12_HUMAN","sp|P30050|RL12_HUMAN",861,"P30050","RL12_HUMAN","60S ribosomal protein L12",null,"RPL12"]
["15.8431","16.2939","16.6952","16.9591",{"$nulls":3},"intracellular signal transduction","ATP binding;magnesium ion binding;protein serine/threonine kinase activity","cytosol;nucleoplasm",{"$nulls":3},1,1,1,"1.7","1.7","1.7","78.366","0.0011287","2.8275",34364000,1,"0.9961","0.295574","-0.758654","-2.90468","tr|A0A0A6YYC0|A0A0A6YYC0_HUMAN;tr|E9PJN1|E9PJN1_HUMAN;sp|O75676|KS6A4_HUMAN","tr|A0A0A6YYC0|A0A0A6YYC0_HUMAN;tr|E9PJN1|E9PJN1_HUMAN;sp|O75676|KS6A4_HUMAN",359,"A0A0A6YYC0","A0A0A6YYC0_HUMAN",null,null,"RPS6KA4"]
["18.0572","18.7785","19.0005","19.3577",{"$nulls":3},"CDP-diacylglycerol biosynthetic process;phosphatidylglycerol biosynthetic process","phosphatidate cytidylyltransferase activity","endoplasmic reticulum membrane;integral component of membrane;membrane;mitochondrial inner membrane","Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,2,2,2,7,7,7,"51.417",0,"7.1775",69412000,10,"0.700938","0.366682","-0.761295","-1.89156","sp|O95674|CDS2_HUMAN","sp|O95674|CDS2_HUMAN",444,"O95674","CDS2_HUMAN","Phosphatidate cytidylyltransferase 2",null,"CDS2"]
["18.2006","17.7833","19.0438","18.4629",{"$nulls":9},3,3,3,"8.6","8.6","8.6","66.476",0,"14.282",63731000,8,"0.777195","0.336901","-0.76138","-2.12894","tr|A0A087WYU1|A0A087WYU1_HUMAN;sp|Q9Y5X1|SNX9_HUMAN;tr|A0A087WVE4|A0A087WVE4_HUMAN;tr|A0A087WZW2|A0A087WZW2_HUMAN","tr|A0A087WYU1|A0A087WYU1_HUMAN;sp|Q9Y5X1|SNX9_HUMAN",3029,"A0A087WYU1"]
["22.6379","22.5989","23.7009","23.0592",{"$nulls":3},"cellular response to actinomycin D;negative regulation of cell cycle arrest;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of ubiquitin protein ligase activity;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of cell cycle arrest;positive regulation of cell proliferation;positive regulation of gene expression;positive regulation of signal transduction by p53 class mediator;positive regulation of transcription from RNA polymerase II promoter;protein stabilization;protein-DNA complex disassembly;ribosomal protein import into nucleus;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","large ribosomal subunit rRNA binding;RNA binding;structural constituent of ribosome;transcription coactivator binding;ubiquitin ligase inhibitor activity;ubiquitin protein ligase binding","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleolus;nucleoplasm;protein complex;ribosome","Ribosome",null,null,5,5,5,"43.6","43.6","43.6","14.865",0,"23.457",808940000,31,"0.849848","0.306387","-0.761668","-2.3696","sp|P62829|RL23_HUMAN;tr|C9JD32|C9JD32_HUMAN;tr|J3KT29|J3KT29_HUMAN;tr|B9ZVP7|B9ZVP7_HUMAN;tr|J3KTJ3|J3KTJ3_HUMAN;tr|J3QQT9|J3QQT9_HUMAN","sp|P62829|RL23_HUMAN;tr|C9JD32|C9JD32_HUMAN;tr|J3KT29|J3KT29_HUMAN;tr|B9ZVP7|B9ZVP7_HUMAN",1317,"P62829","RL23_HUMAN","60S ribosomal protein L23",null,"RPL23"]
["19.0057","20.2986","21.0238","19.8072",{"$nulls":3},"ammonia assimilation cycle;cell proliferation;cellular amino acid biosynthetic process;cellular response to starvation;glutamate catabolic process;glutamine biosynthetic process;neurotransmitter uptake;positive regulation of epithelial cell proliferation;positive regulation of insulin secretion;positive regulation of synaptic transmission, glutamatergic;protein homooligomerization;response to glucose","ATP binding;dynein light chain binding;glutamate binding;glutamate decarboxylase activity;glutamate-ammonia ligase activity;identical protein binding;magnesium ion binding;manganese ion binding","axon terminus;cytosol;extracellular exosome;glial cell projection;mitochondrion;myelin sheath;nucleus;perikaryon;protein complex;rough endoplasmic reticulum","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;GABAergic synapse;Glutamatergic synapse;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Necroptosis;Nitrogen metabolism",null,null,6,6,6,"20.6","20.6","20.6","42.064",0,"41.685",202980000,19,"0.318362","0.712157","-0.763363","-0.859952","sp|P15104|GLNA_HUMAN;tr|A0A087WYJ1|A0A087WYJ1_HUMAN","sp|P15104|GLNA_HUMAN",680,"P15104","GLNA_HUMAN","Glutamine synthetase","S","GLUL"]
["15.0222","15.234","15.8531","15.9308",{"$nulls":9},2,2,2,"1.8","1.8","1.8","113.05",0,"4.863",26005000,3,"1.67522","0.342759","-0.763813","-6.77082","tr|A0A087X1V3|A0A087X1V3_HUMAN;sp|O15164|TIF1A_HUMAN","tr|A0A087X1V3|A0A087X1V3_HUMAN;sp|O15164|TIF1A_HUMAN",204,"A0A087X1V3"]
["18.7632","19.7718","20.3419","19.7221",{"$nulls":3},"cell morphogenesis;COPII vesicle coating;negative regulation of autophagosome assembly;phagocytosis;post-Golgi vesicle-mediated transport;protein transport;regulation of ER to Golgi vesicle-mediated transport;regulation of protein transport;response to hypoxia;response to toxic substance;retrograde vesicle-mediated transport, Golgi to ER;toxin transport;vesicle docking involved in exocytosis","protein N-terminus binding;syntaxin binding","cis-Golgi network;cytosol;endoplasmic reticulum membrane;Golgi cisterna membrane;Golgi transport complex;Golgi-associated vesicle;plasma membrane",{"$nulls":3},6,6,6,"12.8","12.8","12.8","72.379",0,"48.768",306910000,26,"0.487247","0.523378","-0.76449","-1.29152","sp|Q8WVM8|SCFD1_HUMAN;tr|H0YIZ7|H0YIZ7_HUMAN","sp|Q8WVM8|SCFD1_HUMAN",2145,"Q8WVM8","SCFD1_HUMAN","Sec1 family domain-containing protein 1",null,"SCFD1"]
["20.1728","19.9355","21.1713","20.4683",{"$nulls":3},"actin cytoskeleton reorganization;excitatory chemical synaptic transmission","alpha-actinin binding;metal ion binding;protein homodimerization activity;protein phosphatase binding","cell junction;cytoplasm;cytoskeleton;dendritic spine;early endosome lumen;early endosome membrane;filamentous actin;lamellipodium;nucleus;perinuclear region of cytoplasm;postsynaptic membrane;recycling endosome lumen;recycling endosome membrane;stress fiber",{"$nulls":3},5,5,5,"16.7","16.7","16.7","35.398",0,"7.5568",240810000,10,"0.756784","0.335815","-0.765666","-2.06395","sp|P50479|PDLI4_HUMAN;tr|C9J542|C9J542_HUMAN","sp|P50479|PDLI4_HUMAN",1115,"P50479","PDLI4_HUMAN","PDZ and LIM domain protein 4",null,"PDLIM4"]
["14.8236","15.8649","15.9716","16.2487",{"$nulls":3},"activation of protein kinase activity;cell cycle;lymphocyte aggregation;neutrophil degranulation;protein autophosphorylation;protein phosphorylation;regulation of apoptotic process;regulation of lymphocyte migration;regulation of mitotic cell cycle;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;identical protein binding;protein homodimerization activity;protein serine/threonine kinase activity","cytoplasm;extracellular exosome;plasma membrane;specific granule membrane","Progesterone-mediated oocyte maturation",null,null,3,3,3,"5.8","5.8","5.8","112.13",0,"6.1753",22225000,5,"0.536011","0.49251","-0.765875","-1.42156","sp|O94804|STK10_HUMAN","sp|O94804|STK10_HUMAN",392,"O94804","STK10_HUMAN","Serine/threonine-protein kinase 10",null,"STK10"]
["15.9744","15.8295","16.9807","16.3572",{"$nulls":5},"nucleoplasm",{"$nulls":3},1,1,1,8,8,8,"26.267","0.0063228","1.8413",10460000,5,"0.857661","0.30434","-0.767012","-2.3964","tr|Q5T7U0|Q5T7U0_HUMAN;tr|Q5T7U4|Q5T7U4_HUMAN;tr|Q5T7U1|Q5T7U1_HUMAN;sp|Q9Y5Q8|TF3C5_HUMAN","tr|Q5T7U0|Q5T7U0_HUMAN;tr|Q5T7U4|Q5T7U4_HUMAN;tr|Q5T7U1|Q5T7U1_HUMAN;sp|Q9Y5Q8|TF3C5_HUMAN",3024,"Q5T7U0","Q5T7U0_HUMAN",null,null,"GTF3C5"]
["19.955","19.9179","20.8278","20.5851",{"$nulls":3},"macroautophagy;necroptotic process","GTPase activator activity;phosphatase activity;protein complex binding;protein serine/threonine phosphatase activity;signal transducer, downstream of receptor, with serine/threonine phosphatase activity","integral component of membrane;mitochondrial outer membrane;mitochondrion","Mitophagy - animal;Necroptosis;TNF signaling pathway",null,null,4,4,4,"17.6","17.6","17.6","32.004",0,"12.076",241400000,13,"1.61096","0.335464","-0.769991","-6.27174","sp|Q96HS1|PGAM5_HUMAN;tr|F5GXG4|F5GXG4_HUMAN","sp|Q96HS1|PGAM5_HUMAN",2289,"Q96HS1","PGAM5_HUMAN","Serine/threonine-protein phosphatase PGAM5, mitochondrial",null,"PGAM5"]
["16.4538","17.6577","18.4246","17.2272",{"$nulls":3},"cardiac muscle tissue morphogenesis;cellular iron ion homeostasis;heart trabecula formation;labyrinthine layer development;negative regulation of cAMP catabolic process;negative regulation of cyclic-nucleotide phosphodiesterase activity;negative regulation of DNA binding transcription factor activity;oxygen homeostasis;peptidyl-proline hydroxylation to 4-hydroxy-L-proline;positive regulation of transcription from RNA polymerase II promoter;regulation of angiogenesis;regulation of neuron death;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to hypoxia;response to nitric oxide;ventricular septum morphogenesis","enzyme binding;iron ion binding;L-ascorbic acid binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;peptidyl-proline 4-dioxygenase activity;peptidyl-proline dioxygenase activity","cytoplasm;cytosol;nucleus","HIF-1 signaling pathway;Pathways in cancer;Renal cell carcinoma",null,null,3,3,3,"12.4","12.4","12.4","46.02",0,"10.112",32096000,5,"0.337156","0.696601","-0.770146","-0.907121","sp|Q9GZT9|EGLN1_HUMAN","sp|Q9GZT9|EGLN1_HUMAN",2544,"Q9GZT9","EGLN1_HUMAN","Egl nine homolog 1",null,"EGLN1"]
["20.0051","19.9287","21.0539","20.4217",{"$nulls":3},"stem cell development","poly(U) RNA binding;RNA binding","cytoplasm;polysome","mRNA surveillance pathway",null,null,4,4,4,"20.7","20.7","20.7","35.196",0,"16.312",123550000,19,"0.864873","0.302172","-0.770928","-2.42131","sp|Q96DH6|MSI2H_HUMAN;tr|B4DHE8|B4DHE8_HUMAN;tr|J3QKT5|J3QKT5_HUMAN;tr|J3KTC1|J3KTC1_HUMAN;tr|B4DM51|B4DM51_HUMAN","sp|Q96DH6|MSI2H_HUMAN;tr|B4DHE8|B4DHE8_HUMAN;tr|J3QKT5|J3QKT5_HUMAN;tr|J3KTC1|J3KTC1_HUMAN;tr|B4DM51|B4DM51_HUMAN",2257,"Q96DH6","MSI2H_HUMAN","RNA-binding protein Musashi homolog 2","usashi-2","MSI2"]
["15.6085","15.0851","16.629","15.6066",{"$nulls":3},"cytoskeleton organization;multicellular organism development;regulation of cell morphogenesis","DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding","cytoplasm;nucleoplasm",{"$nulls":3},1,1,1,"2.3","2.3","2.3","86.435",0,"5.5691",12246000,5,"0.506478","0.51466","-0.770961","-1.34241","sp|Q2TAL8|QRIC1_HUMAN","sp|Q2TAL8|QRIC1_HUMAN",1775,"Q2TAL8","QRIC1_HUMAN","Glutamine-rich protein 1",null,"QRICH1"]
["14.2884","13.9975","15.0884","14.7426",{"$nulls":5},"integral component of membrane;nuclear membrane;nucleoplasm",{"$nulls":3},1,1,1,"1.3","1.3","1.3","125.09","0.0010989","2.6199",8405100,2,"1.11963","0.309126","-0.772538","-3.41923","tr|A0A075B7F8|A0A075B7F8_HUMAN;sp|A8CG34|P121C_HUMAN","tr|A0A075B7F8|A0A075B7F8_HUMAN;sp|A8CG34|P121C_HUMAN",111,"A0A075B7F8","A0A075B7F8_HUMAN",null,null,"POM121C"]
["20.3062","20.1293","21.1595","20.8212",{"$nulls":3},"DNA replication initiation","ATP binding;DNA binding;DNA helicase activity","cytosol;MCM complex;microtubule cytoskeleton;nucleoplasm",{"$nulls":3},12,12,12,"22.7","22.7","22.7","93.998",0,"147.25",768030000,50,"1.25211","0.326395","-0.772596","-4.04767","tr|H0Y8E6|H0Y8E6_HUMAN;sp|P49736|MCM2_HUMAN","tr|H0Y8E6|H0Y8E6_HUMAN;sp|P49736|MCM2_HUMAN",1088,"H0Y8E6","H0Y8E6_HUMAN","DNA helicase {ECO:0000256|SAAS:SAAS00536514}",null,"MCM2"]
["20.7089","20.6088","22.0216","20.8423",{"$nulls":3},"cell-cell junction organization","metal ion binding","focal adhesion;plasma membrane",{"$nulls":3},4,4,4,"11.6","11.6","11.6","45.724",0,"48.695",321300000,14,"0.492906","0.518694","-0.773114","-1.30644","tr|A0A0J9YXC7|A0A0J9YXC7_HUMAN;tr|F8WC86|F8WC86_HUMAN;sp|P0CW20|LIM3L_HUMAN;sp|P0CW19|LIMS3_HUMAN;tr|A0A0A6YYD2|A0A0A6YYD2_HUMAN;tr|A0A0M3HER1|A0A0M3HER1_HUMAN;sp|P48059|LIMS1_HUMAN","tr|A0A0J9YXC7|A0A0J9YXC7_HUMAN;tr|F8WC86|F8WC86_HUMAN;sp|P0CW20|LIM3L_HUMAN;sp|P0CW19|LIMS3_HUMAN;tr|A0A0A6YYD2|A0A0A6YYD2_HUMAN",3069,"A0A0J9YXC7","A0A0J9YXC7_HUMAN","LIM and senescent cell antigen-like-containing domain protein {ECO:0000256|PIRNR:PIRNR038003}",null,"LIMS4"]
["20.3323","20.4352","22.0456","20.272",{"$nulls":3},"innate immune response;negative regulation of cyclin-dependent protein serine/threonine kinase activity;protein import into nucleus;signal transduction;viral process","GTPase regulator activity;histone binding;protein transporter activity;Ran GTPase binding;SMAD binding;transporter activity","cytosol;membrane;nuclear pore;nucleoplasm",{"$nulls":3},13,13,13,"17.7","17.7","17.7","119.52",0,"43.62",980530000,33,"0.323344","0.708751","-0.775007","-0.872448","sp|O95373|IPO7_HUMAN;tr|E9PLJ0|E9PLJ0_HUMAN;tr|E9PLB2|E9PLB2_HUMAN","sp|O95373|IPO7_HUMAN",429,"O95373","IPO7_HUMAN","Importin-7","mp7","IPO7"]
["19.0726","18.4249","19.8982","19.1524",{"$nulls":3},"anatomical structure morphogenesis;mRNA transport;negative regulation of translation;regulation of cytokine biosynthetic process;regulation of mRNA stability;translation","mRNA 3'-UTR binding;mRNA 5'-UTR binding;RNA binding;translation regulator activity","cytoplasm;cytosol;nucleus",{"$nulls":3},7,6,6,"17.8","15.5","15.5","63.704",0,"33.183",177510000,35,"0.590875","0.446642","-0.776495","-1.57221","sp|O00425|IF2B3_HUMAN;tr|F8WD15|F8WD15_HUMAN","sp|O00425|IF2B3_HUMAN",140,"O00425","IF2B3_HUMAN","Insulin-like growth factor 2 mRNA-binding protein 3","GF2 mRNA-binding protein 3;MP-3","IGF2BP3"]
["18.2627","17.5282","19.0231","18.3228",{"$nulls":3},"cellular response to stimulus;central nervous system development;myelination;oligodendrocyte development;ovarian follicle development;regulation of molecular function;regulation of translational initiation;response to glucose;response to heat;response to peptide hormone;translational initiation","ATP binding;GTP binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex","Herpes simplex virus 1 infection;RNA transport",null,null,2,2,2,"9.7","9.7","9.7","38.989",0,"8.3723",63850000,12,"0.576437","0.460635","-0.777482","-1.53208","sp|P49770|EI2BB_HUMAN;tr|H0YJJ8|H0YJJ8_HUMAN;tr|G3V5E5|G3V5E5_HUMAN","sp|P49770|EI2BB_HUMAN;tr|H0YJJ8|H0YJJ8_HUMAN;tr|G3V5E5|G3V5E5_HUMAN",1094,"P49770","EI2BB_HUMAN","Translation initiation factor eIF-2B subunit beta",null,"EIF2B2"]
["19.8286","21.4008","21.4618","21.3258",{"$nulls":3},"astrocyte development;Bergmann glial cell differentiation;cellular response to interferon-gamma;intermediate filament organization;lens fiber cell development;movement of cell or subcellular component;muscle filament sliding;negative regulation of neuron projection development;positive regulation of collagen biosynthetic process;positive regulation of translation;regulation of mRNA stability;SMAD protein signal transduction;viral process","double-stranded RNA binding;identical protein binding;keratin filament binding;protein C-terminus binding;protein domain specific binding;scaffold protein binding;structural constituent of cytoskeleton;structural constituent of eye lens","cell leading edge;cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular matrix;focal adhesion;intermediate filament;intracellular ribonucleoprotein complex;neuron projection;peroxisome;phagocytic vesicle;plasma membrane;polysome","Epstein-Barr virus infection;MicroRNAs in cancer",null,null,17,15,15,"43.6","39.9","39.9","53.651",0,"55.809",1032400000,67,"0.369007","0.6603","-0.779046","-0.987334","sp|P08670|VIME_HUMAN;tr|B0YJC4|B0YJC4_HUMAN;tr|B0YJC5|B0YJC5_HUMAN;tr|Q5JVS8|Q5JVS8_HUMAN;sp|P17661|DESM_HUMAN","sp|P08670|VIME_HUMAN;tr|B0YJC4|B0YJC4_HUMAN;tr|B0YJC5|B0YJC5_HUMAN",568,"P08670","VIME_HUMAN","Vimentin",null,"VIM"]
["15.4748","14.7465","15.947","15.8325",{"$nulls":5},"Golgi apparatus;integral component of membrane",{"$nulls":3},1,1,1,"5.9","5.9","5.9","44.772",0,"22.724",8301100,1,"0.772373","0.337229","-0.779092","-2.11348","sp|Q96K37|S35E1_HUMAN","sp|Q96K37|S35E1_HUMAN",2314,"Q96K37","S35E1_HUMAN","Solute carrier family 35 member E1",null,"SLC35E1"]
["19.3241","19.0391","20.0654","19.8582",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"26.4","26.4","26.4","14.6",0,"6.7076",42245000,9,"1.32425","0.333443","-0.7802","-4.4284","tr|B4DDK6|B4DDK6_HUMAN;sp|O14925|TIM23_HUMAN;sp|Q5SRD1|TI23B_HUMAN","tr|B4DDK6|B4DDK6_HUMAN;sp|O14925|TIM23_HUMAN;sp|Q5SRD1|TI23B_HUMAN",181,"B4DDK6","B4DDK6_HUMAN",null,null,"TIMM23B"]
["20.9346","19.744","21.3788","20.8605",{"$nulls":3},"activation of GTPase activity;cell division;chromosome passenger complex localization to kinetochore;establishment of protein localization;focal adhesion assembly;integrin-mediated signaling pathway;negative regulation of focal adhesion assembly;negative regulation of GTPase activity;negative regulation of substrate adhesion-dependent cell spreading;positive regulation of attachment of spindle microtubules to kinetochore;positive regulation of G2/M transition of mitotic cell cycle;regulation of cell migration;regulation of fibroblast migration;regulation of ruffle assembly;sister chromatid cohesion","microtubule binding;protein domain specific binding;protein kinase binding;Rac GTPase binding;RNA binding;small GTPase binding","chromosome, centromeric core domain;cytosol;early endosome membrane;microtubule;midbody;mitotic spindle midzone;nucleolus;plasma membrane",{"$nulls":3},5,5,5,"15.5","15.5","15.5","56.084",0,"29.266",352260000,34,"0.452934","0.551009","-0.780303","-1.20185","sp|Q9P258|RCC2_HUMAN","sp|Q9P258|RCC2_HUMAN",2780,"Q9P258","RCC2_HUMAN","Protein RCC2",null,"RCC2"]
["16.5894","16.3079","17.6142","16.8438",{"$nulls":4},"protein tyrosine phosphatase activity","cytosol;integral component of membrane;nucleoplasm",{"$nulls":3},2,2,2,"9.1","9.1","9.1","44.562",0,"14.055",29897000,11,"0.704631","0.363576","-0.780336","-1.90272","tr|K7EQG9|K7EQG9_HUMAN;sp|P17706|PTN2_HUMAN;tr|K7EIY0|K7EIY0_HUMAN;tr|K7ENP9|K7ENP9_HUMAN;tr|K7EIE9|K7EIE9_HUMAN;tr|K7ER87|K7ER87_HUMAN","tr|K7EQG9|K7EQG9_HUMAN;sp|P17706|PTN2_HUMAN;tr|K7EIY0|K7EIY0_HUMAN;tr|K7ENP9|K7ENP9_HUMAN;tr|K7EIE9|K7EIE9_HUMAN;tr|K7ER87|K7ER87_HUMAN",710,"K7EQG9","K7EQG9_HUMAN","Tyrosine-protein phosphatase non-receptor type {ECO:0000256|PIRNR:PIRNR000926}",null,"PTPN2"]
["20.663","20.7434","21.6265","21.3419",{"$nulls":4},"GTP binding;GTPase activity","integral component of membrane",{"$nulls":3},9,9,9,"25.4","25.4","25.4","58.772",0,"48.457",671640000,67,"1.46825","0.322114","-0.781011","-5.28226","tr|F5H6I7|F5H6I7_HUMAN;sp|Q6DD88|ATLA3_HUMAN;tr|F5GWF8|F5GWF8_HUMAN","tr|F5H6I7|F5H6I7_HUMAN;sp|Q6DD88|ATLA3_HUMAN",1863,"F5H6I7","F5H6I7_HUMAN",null,null,"ATL3"]
["17.5231","16.8934","18.3695","17.6095",{"$nulls":4},"ubiquitin-like modifier activating enzyme activity","cytosol;intracellular membrane-bounded organelle",{"$nulls":3},1,1,1,"5.6","5.6","5.6","41.85",0,"3.7612",35011000,9,"0.594746","0.442809","-0.78122","-1.58304","tr|E7EQ61|E7EQ61_HUMAN;sp|Q9GZZ9|UBA5_HUMAN","tr|E7EQ61|E7EQ61_HUMAN;sp|Q9GZZ9|UBA5_HUMAN",2548,"E7EQ61","E7EQ61_HUMAN",null,null,"UBA5"]
["17.8084","17.7223","18.8083","18.2864",{"$nulls":3},"glomerular visceral epithelial cell development;glomerular visceral epithelial cell migration;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;negative regulation of hydrogen peroxide-induced cell death;nuclear envelope organization;nuclear pore complex assembly;poly(A)+ mRNA export from nucleus;positive regulation of SMAD protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;renal system development;SMAD protein signal transduction;tRNA export from nucleus;viral process;viral transcription","structural constituent of nuclear pore","host cell;membrane;nuclear envelope;nuclear membrane;nuclear periphery;nuclear pore","RNA transport",null,null,5,5,5,"8.1","8.1","8.1","93.487",0,"12.096",181720000,15,"1.00933","0.296044","-0.78197","-2.95684","sp|Q8N1F7|NUP93_HUMAN;tr|H3BVG0|H3BVG0_HUMAN;tr|H3BRD9|H3BRD9_HUMAN;tr|H3BV15|H3BV15_HUMAN;tr|H3BVE2|H3BVE2_HUMAN;tr|H3BNN5|H3BNN5_HUMAN;tr|H3BV11|H3BV11_HUMAN;tr|H3BRI8|H3BRI8_HUMAN;tr|H3BM93|H3BM93_HUMAN","sp|Q8N1F7|NUP93_HUMAN;tr|H3BVG0|H3BVG0_HUMAN",2036,"Q8N1F7","NUP93_HUMAN","Nuclear pore complex protein Nup93",null,"NUP93"]
["20.2176","20.5783","21.5451","20.8162",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;protein methylation;regulation of translational termination;translational termination","ribosome binding;RNA binding;sequence-specific mRNA binding;translation release factor activity;translation termination factor activity","cytoplasm;cytosol","mRNA surveillance pathway",null,null,10,10,10,"31.6","31.6","31.6","49.03",0,"21.305",538190000,29,"0.711943","0.360631","-0.782678","-1.92493","sp|P62495|ERF1_HUMAN;tr|B7Z7P8|B7Z7P8_HUMAN;tr|I3L492|I3L492_HUMAN;tr|D6RCB3|D6RCB3_HUMAN;tr|D6RJE8|D6RJE8_HUMAN","sp|P62495|ERF1_HUMAN;tr|B7Z7P8|B7Z7P8_HUMAN",1308,"P62495","ERF1_HUMAN","Eukaryotic peptide chain release factor subunit 1","RF1;ukaryotic release factor 1","ETF1"]
["21.7817","21.4368","23.1317","21.6524",{"$nulls":3},"canonical glycolysis;epithelial cell differentiation;fructose 1,6-bisphosphate metabolic process;fructose metabolic process;gluconeogenesis;neutrophil degranulation","cytoskeletal protein binding;fructose-bisphosphate aldolase activity","cytoskeleton;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;mitochondrion;secretory granule lumen;tertiary granule lumen","Biosynthesis of amino acids;Carbon metabolism;Fructose and mannose metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;Pentose phosphate pathway",null,null,4,1,1,"18.4","6.3","6.3","39.455",0,"96.726",1327600000,47,"0.386144","0.633154","-0.782771","-1.0307","sp|P09972|ALDOC_HUMAN;tr|A8MVZ9|A8MVZ9_HUMAN;tr|K7EKH5|K7EKH5_HUMAN;tr|C9J8F3|C9J8F3_HUMAN;tr|J3KSV6|J3KSV6_HUMAN;tr|J3QKP5|J3QKP5_HUMAN","sp|P09972|ALDOC_HUMAN;tr|A8MVZ9|A8MVZ9_HUMAN",598,"P09972","ALDOC_HUMAN","Fructose-bisphosphate aldolase C",null,"ALDOC"]
["16.7495","16.7835","17.9557","17.1435",{"$nulls":3},"activation of MAPK activity;CAMKK-AMPK signaling cascade;cell cycle arrest;cellular response to ethanol;cellular response to glucose starvation;cellular response to hydrogen peroxide;cellular response to hypoxia;cellular response to nutrient levels;cellular response to organonitrogen compound;cellular response to prostaglandin E stimulus;cholesterol biosynthetic process;cold acclimation;fatty acid biosynthetic process;fatty acid homeostasis;fatty acid oxidation;glucose homeostasis;glucose metabolic process;lipid biosynthetic process;macroautophagy;negative regulation of apoptotic process;negative regulation of glucose import in response to insulin stimulus;negative regulation of glucosylceramide biosynthetic process;negative regulation of lipid catabolic process;negative regulation of TOR signaling;positive regulation of autophagy;positive regulation of cell proliferation;positive regulation of cholesterol biosynthetic process;positive regulation of gene expression;positive regulation of glycolytic process;positive regulation of skeletal muscle tissue development;protein heterooligomerization;protein phosphorylation;regulation of circadian rhythm;regulation of energy homeostasis;regulation of macroautophagy;regulation of peptidyl-serine phosphorylation;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;regulation of vesicle-mediated transport;response to activity;response to caffeine;response to camptothecin;response to gamma radiation;response to hypoxia;response to UV;rhythmic process;signal transduction;transcription, DNA-templated;Wnt signaling pathway","[acetyl-CoA carboxylase] kinase activity;[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity;AMP-activated protein kinase activity;ATP binding;cAMP-dependent protein kinase activity;chromatin binding;histone serine kinase activity;metal ion binding;protein C-terminus binding;protein kinase activity;tau-protein kinase activity","apical plasma membrane;cytoplasm;cytosol;intracellular;nuclear speck;nucleoplasm;nucleotide-activated protein kinase complex;nucleus","Adipocytokine signaling pathway;AMPK signaling pathway;Apelin signaling pathway;Autophagy - animal;Circadian rhythm;Fluid shear stress and atherosclerosis;FoxO signaling pathway;Glucagon signaling pathway;Hypertrophic cardiomyopathy (HCM);Insulin resistance;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;mTOR signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Oxytocin signaling pathway;PI3K-Akt signaling pathway;Thermogenesis;Tight junction",null,null,2,2,2,"4.8","4.8","4.8","64.009","0.00076365","2.9548",47014000,4,"0.712491","0.361022","-0.783092","-1.9266","sp|Q13131|AAPK1_HUMAN;tr|Q96E92|Q96E92_HUMAN;tr|A0A087WXX9|A0A087WXX9_HUMAN;sp|P54646|AAPK2_HUMAN","sp|Q13131|AAPK1_HUMAN;tr|Q96E92|Q96E92_HUMAN;tr|A0A087WXX9|A0A087WXX9_HUMAN;sp|P54646|AAPK2_HUMAN",1524,"Q13131","AAPK1_HUMAN","5'-AMP-activated protein kinase catalytic subunit alpha-1","MPK subunit alpha-1","PRKAA1"]
["20.4105","20.2564","21.2346","21.0003",{"$nulls":3},"locomotory exploration behavior;pigmentation",null,"extracellular exosome;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},7,7,7,"25.8","25.8","25.8","42.449",0,"121.55",378860000,29,"1.51527","0.324","-0.78403","-5.59129","sp|Q9HB07|MYG1_HUMAN;tr|F8VR84|F8VR84_HUMAN;tr|F8VQQ3|F8VQQ3_HUMAN","sp|Q9HB07|MYG1_HUMAN;tr|F8VR84|F8VR84_HUMAN;tr|F8VQQ3|F8VQQ3_HUMAN",2632,"Q9HB07","MYG1_HUMAN","UPF0160 protein MYG1, mitochondrial",null,"C12orf10"]
["18.6664","18.5605","19.5467","19.2529",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"9.7","9.7","9.7","21.127",0,"55.247",53771000,14,"1.42875","0.336469","-0.78633","-5.03461","tr|Q5T8U5|Q5T8U5_HUMAN;sp|O15260|SURF4_HUMAN","tr|Q5T8U5|Q5T8U5_HUMAN;sp|O15260|SURF4_HUMAN",208,"Q5T8U5","Q5T8U5_HUMAN"]
["17.0479","17.2739","18.3895","17.5055",{"$nulls":9},7,1,1,"31.3","7.3","7.3","20.621",0,"12.17",30967000,6,"0.644274","0.401162","-0.786571","-1.72403","tr|K7ENT6|K7ENT6_HUMAN;tr|K7ERG3|K7ERG3_HUMAN","tr|K7ENT6|K7ENT6_HUMAN;tr|K7ERG3|K7ERG3_HUMAN",3112,"K7ENT6","K7ENT6_HUMAN",null,null,"TPM4"]
["19.3523","19.4471","20.4011","19.9749",{"$nulls":3},"transcription, DNA-templated","DNA binding;DNA-directed 5'-3' RNA polymerase activity","nucleoplasm",{"$nulls":3},3,3,3,"18.5","18.5","18.5","21.459",0,"52.692",85448000,9,"1.16201","0.315488","-0.78834","-3.611","tr|A0A087WVZ9|A0A087WVZ9_HUMAN;tr|A0A0A0MQR7|A0A0A0MQR7_HUMAN;sp|P19388|RPAB1_HUMAN;tr|A0A087WWX0|A0A087WWX0_HUMAN;tr|A0A087WVN5|A0A087WVN5_HUMAN","tr|A0A087WVZ9|A0A087WVZ9_HUMAN;tr|A0A0A0MQR7|A0A0A0MQR7_HUMAN;sp|P19388|RPAB1_HUMAN;tr|A0A087WWX0|A0A087WWX0_HUMAN",731,"A0A087WVZ9","A0A087WVZ9_HUMAN",null,null,"POLR2E"]
["18.9449","18.728","19.8885","19.3618",{"$nulls":4},"methyltransferase activity",{"$nulls":4},1,1,1,"5.7","5.7","5.7","27.775",0,"16.908",68297000,13,"0.960975","0.292787","-0.788714","-2.76939","sp|Q6UX53|MET7B_HUMAN;tr|A0A087WZT2|A0A087WZT2_HUMAN","sp|Q6UX53|MET7B_HUMAN;tr|A0A087WZT2|A0A087WZT2_HUMAN",1904,"Q6UX53","MET7B_HUMAN","Methyltransferase-like protein 7B",null,"METTL7B"]
["16.3665","17.3437","18.1664","17.1257",{"$nulls":3},"intracellular signal transduction","metal ion binding","intracellular",{"$nulls":3},2,2,2,13,13,13,"35.487","0.0011021","2.6523",20928000,6,"0.41652","0.599812","-0.790947","-1.10806","tr|J3KRN5|J3KRN5_HUMAN;sp|P17252|KPCA_HUMAN","tr|J3KRN5|J3KRN5_HUMAN;sp|P17252|KPCA_HUMAN",706,"J3KRN5","J3KRN5_HUMAN",null,null,"PRKCA"]
["15.3194","16.2319","16.2024","16.9327",{"$nulls":4},"chromatin binding;DNA binding transcription factor activity;sequence-specific DNA binding;zinc ion binding","cytosol;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},3,3,3,"6.7","6.7","6.7","79.372",0,"11.2",39676000,11,"0.511272","0.51146","-0.79195","-1.35517","tr|E7ESY4|E7ESY4_HUMAN;sp|Q13330|MTA1_HUMAN;tr|H0Y4T7|H0Y4T7_HUMAN;tr|F8VPC5|F8VPC5_HUMAN;tr|H0YIT0|H0YIT0_HUMAN;tr|E9PF88|E9PF88_HUMAN;tr|E9PCS8|E9PCS8_HUMAN;tr|E7EQY4|E7EQY4_HUMAN;tr|E7EV10|E7EV10_HUMAN;sp|Q9BTC8|MTA3_HUMAN","tr|E7ESY4|E7ESY4_HUMAN;sp|Q13330|MTA1_HUMAN;tr|H0Y4T7|H0Y4T7_HUMAN",1544,"E7ESY4","E7ESY4_HUMAN",null,null,"MTA1"]
["16.9533","16.5977","17.9072","17.2295",{"$nulls":3},"cell differentiation;cellular response to fibroblast growth factor stimulus;cellular response to interleukin-2;cellular response to nerve growth factor stimulus;cellular response to prolactin;cellular response to wortmannin;DNA repair;mitotic cell cycle;mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter;signal transduction involved in DNA damage checkpoint","DNA binding;leucine zipper domain binding;protein kinase binding;protein phosphatase 1 binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;transcription corepressor binding;transcription factor activity, RNA polymerase II transcription factor recruiting;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;WD40-repeat domain binding","catalytic step 2 spliceosome;cytoplasm;membrane;nuclear speck;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein-DNA complex;Prp19 complex","Spliceosome",null,null,4,4,4,"8.9","8.9","8.9","92.25",0,"10.417",53519000,22,"0.759255","0.336986","-0.79279","-2.07176","sp|Q99459|CDC5L_HUMAN","sp|Q99459|CDC5L_HUMAN",2372,"Q99459","CDC5L_HUMAN","Cell division cycle 5-like protein","dc5-like protein","CDC5L"]
["17.7583","17.8301","18.147","19.0282",{"$nulls":3},"cell division;DNA-dependent DNA replication;sister chromatid cohesion","chromatin binding","cytosol;nuclear chromatin;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},3,3,3,"8.1","8.1","8.1","72.979",0,"63.105",130880000,13,"0.668482","0.387352","-0.79338","-1.79475","sp|Q9BTE3|MCMBP_HUMAN","sp|Q9BTE3|MCMBP_HUMAN",2444,"Q9BTE3","MCMBP_HUMAN","Mini-chromosome maintenance complex-binding protein","CM-binding protein;CM-BP","MCMBP"]
["21.8759","21.9145","22.691","22.6878",{"$nulls":3},"cell differentiation;cellular amino acid metabolic process;L-alpha-amino acid transmembrane transport;leukocyte migration;nervous system development;neutral amino acid transport;transport","amino acid transmembrane transporter activity;antiporter activity;L-amino acid transmembrane transporter activity;neutral amino acid transmembrane transporter activity;peptide antigen binding","apical plasma membrane;cytosol;extracellular exosome;integral component of plasma membrane;intracellular membrane-bounded organelle;membrane;plasma membrane","Central carbon metabolism in cancer;mTOR signaling pathway",null,null,3,3,3,"8.7","8.7","8.7","55.01",0,"17.001",896790000,21,"3.22493","0.419556","-0.79418","-40.9514","sp|Q01650|LAT1_HUMAN","sp|Q01650|LAT1_HUMAN",1418,"Q01650","LAT1_HUMAN","Large neutral amino acids transporter small subunit 1",null,"SLC7A5"]
["17.4976","18.4349","19.1614","18.3612",{"$nulls":5},"Golgi apparatus;integral component of membrane;nucleoplasm;trans-Golgi network",{"$nulls":3},4,4,4,"12.1","12.1","12.1","47.879",0,"91.967",71255000,18,"0.486781","0.522998","-0.795064","-1.29029","tr|J3KQ45|J3KQ45_HUMAN;tr|F8W8W7|F8W8W7_HUMAN;sp|O43493|TGON2_HUMAN","tr|J3KQ45|J3KQ45_HUMAN;tr|F8W8W7|F8W8W7_HUMAN;sp|O43493|TGON2_HUMAN",249,"J3KQ45","J3KQ45_HUMAN",null,null,"TGOLN2"]
["21.3131","21.0495","21.7569","22.1986",{"$nulls":3},"intralumenal vesicle formation;membrane invagination;negative regulation of early endosome to late endosome transport;negative regulation of phagocytosis;negative regulation of protein catabolic process;negative regulation of protein transport;negative regulation of viral entry into host cell;positive regulation of neuron projection development;protein deubiquitination;protein to membrane docking;protein transport;regulation of Wnt signaling pathway;response to bacterium;Wnt signaling pathway","phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-3-phosphate binding;phosphatidylinositol-4-phosphate binding;phosphatidylinositol-5-phosphate binding;protein phosphatase binding","clathrin-coated vesicle;cytoplasm;cytosol;early endosome;early endosome membrane;early phagosome;endosome membrane;extracellular exosome;extrinsic component of membrane","Endocytosis",null,null,2,2,2,"14.2","14.2","14.2","18.762",0,"12.785",295910000,10,"1.04394","0.300133","-0.796477","-3.09652","sp|O60493|SNX3_HUMAN","sp|O60493|SNX3_HUMAN",289,"O60493","SNX3_HUMAN","Sorting nexin-3",null,"SNX3"]
["15.9433","15.9088","17.216","16.2299",{"$nulls":3},"adult locomotory behavior;cellular protein metabolic process;feeding behavior;homeostasis of number of cells within a tissue;insulin-like growth factor receptor signaling pathway;mitotic G1 DNA damage checkpoint;mRNA destabilization;multicellular organism growth;musculoskeletal movement;negative regulation of translation;neuromuscular process controlling balance;post-embryonic development;posttranscriptional gene silencing;spinal cord motor neuron differentiation","cadherin binding;proline-rich region binding;RNA binding","cytoplasmic stress granule;cytosol;endoplasmic reticulum;endosome;Golgi apparatus;integral component of membrane;membrane;perikaryon;protein complex;proximal dendrite",{"$nulls":3},3,3,3,3,3,3,"150.07",0,"20.107",46938000,9,"0.606223","0.429142","-0.796908","-1.61529","sp|Q6Y7W6|PERQ2_HUMAN;tr|I1E4Y6|I1E4Y6_HUMAN;tr|C9JH18|C9JH18_HUMAN;tr|C9JHW1|C9JHW1_HUMAN;tr|E7ESB6|E7ESB6_HUMAN","sp|Q6Y7W6|PERQ2_HUMAN;tr|I1E4Y6|I1E4Y6_HUMAN",1911,"Q6Y7W6","GGYF2_HUMAN","GRB10-interacting GYF protein 2 {ECO:0000303|PubMed:12771153}"]
["19.6167","19.1016","20.6248","19.6878",{"$nulls":3},"adaptive immune response;arginine metabolic process;innate immune response;negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process;negative regulation of CD4-positive, alpha-beta T cell proliferation;negative regulation of chemokine (C-C motif) ligand 4 production;negative regulation of chemokine (C-C motif) ligand 5 production;negative regulation of defense response to bacterium;negative regulation of interleukin-13 secretion;negative regulation of interleukin-17 secretion;negative regulation of macrophage inflammatory protein 1 alpha production;negative regulation of tumor necrosis factor production;negative regulation of tumor necrosis factor secretion;negative regulation of type 2 immune response;nitric oxide biosynthetic process;positive regulation of cellular senescence;regulation of interleukin-1 beta secretion;regulation of reactive oxygen species biosynthetic process;striated muscle contraction;urea cycle;ureteric bud development","arginase activity;metal ion binding","mitochondrial matrix;mitochondrion","Amoebiasis;Arginine and proline metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Metabolic pathways",null,null,4,4,4,"19.5","19.5","19.5","38.577",0,"13.122",119140000,19,"0.561531","0.472027","-0.797128","-1.49102","sp|P78540|ARGI2_HUMAN","sp|P78540|ARGI2_HUMAN",1374,"P78540","ARGI2_HUMAN","Arginase-2, mitochondrial",null,"ARG2"]
["21.8587","21.7892","22.7197","22.5226",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},3,3,3,"31.6","31.6","31.6","12.656",0,"7.5392",313980000,16,"1.77624","0.361935","-0.797197","-7.63154","tr|E5RI99|E5RI99_HUMAN;sp|P62888|RL30_HUMAN;tr|E5RJH3|E5RJH3_HUMAN;tr|A0A0C4DH44|A0A0C4DH44_HUMAN;tr|A0A0B4J213|A0A0B4J213_HUMAN","tr|E5RI99|E5RI99_HUMAN;sp|P62888|RL30_HUMAN;tr|E5RJH3|E5RJH3_HUMAN;tr|A0A0C4DH44|A0A0C4DH44_HUMAN",1328,"E5RI99","E5RI99_HUMAN",null,null,"RPL30"]
["17.7483","17.2197","18.3672","18.1973",{"$nulls":3},"activation of MAPKK activity;animal organ morphogenesis;anterior/posterior pattern specification;blood vessel development;heart development;intracellular signal transduction;JNK cascade;parathyroid gland development;positive regulation of cell proliferation;positive regulation of substrate adhesion-dependent cell spreading;Ras protein signal transduction;thymus development","cadherin binding;identical protein binding;phosphotyrosine residue binding;RNA binding;SH3/SH2 adaptor activity;signal transducer activity","cytosol;endosome;extracellular exosome","Bacterial invasion of epithelial cells;Chemokine signaling pathway;Chronic myeloid leukemia;ErbB signaling pathway;Fc gamma R-mediated phagocytosis;Focal adhesion;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Insulin signaling pathway;MAPK signaling pathway;MicroRNAs in cancer;Neurotrophin signaling pathway;Pathways in cancer;Rap1 signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Shigellosis;Yersinia infection",null,null,3,3,3,"19.5","19.5","19.5","33.777",0,"3.5381",36477000,9,"0.988528","0.298657","-0.798255","-2.87513","sp|P46109|CRKL_HUMAN","sp|P46109|CRKL_HUMAN",1025,"P46109","CRKL_HUMAN","Crk-like protein",null,"CRKL"]
["18.784","18.59","19.6506","19.3207",{"$nulls":9},1,1,1,"12.2","12.2","12.2","18.837","0.0004","3.3631",46886000,2,"1.27659","0.32795","-0.798616","-4.1736","tr|A0A087WXE2|A0A087WXE2_HUMAN;sp|Q8IZ73|RUSD2_HUMAN","tr|A0A087WXE2|A0A087WXE2_HUMAN;sp|Q8IZ73|RUSD2_HUMAN",2028,"A0A087WXE2","A0A087WXE2_HUMAN",null,null,"RPUSD2"]
["18.8169","20.8713","20.655","20.6306",{"$nulls":3},"activation of innate immune response;alternative mRNA splicing, via spliceosome;double-strand break repair via homologous recombination;histone H3 deacetylation;innate immune response;mRNA processing;negative regulation of circadian rhythm;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;positive regulation of sister chromatid cohesion;positive regulation of transcription from RNA polymerase II promoter;regulation of circadian rhythm;rhythmic process;RNA splicing;transcription, DNA-templated","chromatin binding;core promoter binding;DNA binding;histone deacetylase binding;protein homodimerization activity;RNA binding;RNA polymerase II distal enhancer sequence-specific DNA binding;transcription regulatory region DNA binding;transcription regulatory region sequence-specific DNA binding","chromatin;cytoplasm;extracellular matrix;nuclear matrix;nuclear speck;nucleoplasm;nucleus;paraspeckles;RNA polymerase II transcription factor complex",{"$nulls":3},10,8,8,17,"15.6","15.6","76.149",0,"42.076",237710000,26,"0.285464","0.746777","-0.798692","-0.777471","sp|P23246|SFPQ_HUMAN;tr|H0Y9K7|H0Y9K7_HUMAN;tr|H0Y9U2|H0Y9U2_HUMAN","sp|P23246|SFPQ_HUMAN",773,"P23246","SFPQ_HUMAN","Splicing factor, proline- and glutamine-rich",null,"SFPQ"]
["15.9955","16.4957","16.8638","17.2251",{"$nulls":5},"membrane;nucleus",{"$nulls":3},1,1,1,"1.4","1.4","1.4","118.58",0,"14.194",55603000,1,"0.912247","0.293884","-0.798777","-2.58903","sp|Q5M775|CYTSB_HUMAN","sp|Q5M775|CYTSB_HUMAN",1819,"Q5M775","CYTSB_HUMAN","Cytospin-B",null,"SPECC1"]
["17.4581","18.1003","18.6633","18.5034",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;negative regulation of protein catabolic process;protein complex assembly;RNA splicing;RNA splicing, via transesterification reactions","protein complex binding;RNA binding","catalytic step 2 spliceosome;nucleolus;nucleoplasm;nucleus;small nuclear ribonucleoprotein complex;spliceosomal complex;U12-type spliceosomal complex","Spliceosome",null,null,5,5,5,"6.3","6.3","6.3","135.58",0,"24.72",153850000,34,"0.867455","0.301572","-0.804122","-2.43026","sp|Q15393|SF3B3_HUMAN","sp|Q15393|SF3B3_HUMAN",1698,"Q15393","SF3B3_HUMAN","Splicing factor 3B subunit 3",null,"SF3B3"]
["15.8637","16.0826","16.8516","16.7033",{"$nulls":3},"spliceosomal tri-snRNP complex assembly",null,"spliceosomal complex",{"$nulls":3},1,1,1,"4.2","4.2","4.2","43.472","0.0011091","2.719",15026000,4,"1.5855","0.335208","-0.804339","-6.08357","sp|Q9Y312|AAR2_HUMAN;tr|A2A2Q9|A2A2Q9_HUMAN","sp|Q9Y312|AAR2_HUMAN;tr|A2A2Q9|A2A2Q9_HUMAN",2967,"Q9Y312","AAR2_HUMAN","Protein AAR2 homolog",null,"AAR2"]
["16.5466","16.083","17.2045","17.0349",{"$nulls":3},"activation of protein kinase B activity;activation-induced cell death of T cells;aging;anoikis;apoptotic mitochondrial changes;cell differentiation;cell projection organization;cell proliferation;cellular protein modification process;cellular response to cadmium ion;cellular response to DNA damage stimulus;cellular response to epidermal growth factor stimulus;cellular response to granulocyte macrophage colony-stimulating factor stimulus;cellular response to hypoxia;cellular response to insulin stimulus;cellular response to mechanical stimulus;cellular response to nerve growth factor stimulus;cellular response to organic cyclic compound;cellular response to prostaglandin E stimulus;cellular response to reactive oxygen species;cellular response to tumor necrosis factor;cellular response to vascular endothelial growth factor stimulus;chemical synaptic transmission, postsynaptic;endocrine pancreas development;epidermal growth factor receptor signaling pathway;establishment of protein localization to mitochondrion;execution phase of apoptosis;germ cell development;glucose homeostasis;glucose metabolic process;glucose transport;glycogen biosynthetic process;glycogen cell differentiation involved in embryonic placenta development;G-protein coupled receptor signaling pathway;hyaluronan metabolic process;I-kappaB kinase/NF-kappaB signaling;inflammatory response;insulin receptor signaling pathway;insulin-like growth factor receptor signaling pathway;interleukin-18-mediated signaling pathway;intracellular signal transduction;labyrinthine layer blood vessel development;lipopolysaccharide-mediated signaling pathway;maintenance of protein location in mitochondrion;mammary gland epithelial cell differentiation;maternal placenta development;negative regulation of apoptotic process;negative regulation of autophagy;negative regulation of cell size;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of endopeptidase activity;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;negative regulation of fatty acid beta-oxidation;negative regulation of gene expression;negative regulation of JNK cascade;negative regulation of macroautophagy;negative regulation of neuron death;negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;negative regulation of plasma membrane long-chain fatty acid transport;negative regulation of protein kinase activity;negative regulation of protein kinase activity by protein phosphorylation;negative regulation of protein kinase B signaling;negative regulation of proteolysis;negative regulation of release of cytochrome c from mitochondria;NIK/NF-kappaB signaling;nitric oxide biosynthetic process;osteoblast differentiation;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;peripheral nervous system myelin maintenance;phosphatidylinositol 3-kinase signaling;phosphorylation;platelet activation;positive regulation of apoptotic process;positive regulation of blood vessel endothelial cell migration;positive regulation of cell growth;positive regulation of cell proliferation;positive regulation of cellular protein metabolic process;positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;positive regulation of DNA binding transcription factor activity;positive regulation of endodeoxyribonuclease activity;positive regulation of endothelial cell proliferation;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of fat cell differentiation;positive regulation of fibroblast migration;positive regulation of glucose import;positive regulation of glucose metabolic process;positive regulation of glycogen biosynthetic process;positive regulation of I-kappaB phosphorylation;positive regulation of lipid biosynthetic process;positive regulation of mitochondrial membrane potential;positive regulation of nitric oxide biosynthetic process;positive regulation of nitric-oxide synthase activity;positive regulation of organ growth;positive regulation of peptidyl-serine phosphorylation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein localization to nucleus;positive regulation of protein localization to plasma membrane;positive regulation of protein phosphorylation;positive regulation of smooth muscle cell proliferation;positive regulation of sodium ion transport;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of vasoconstriction;protein autophosphorylation;protein catabolic process;protein import into nucleus, translocation;protein kinase B signaling;protein phosphorylation;protein ubiquitination;regulation of apoptotic process;regulation of cell cycle checkpoint;regulation of cell migration;regulation of glycogen biosynthetic process;regulation of mRNA stability;regulation of myelination;regulation of neuron projection development;regulation of nitric-oxide synthase activity;regulation of signal transduction by p53 class mediator;regulation of translation;response to fluid shear stress;response to food;response to growth hormone;response to heat;response to insulin-like growth factor stimulus;response to oxidative stress;response to UV-A;signal transduction;spinal cord development;striated muscle cell differentiation;T cell costimulation;TOR signaling;translation","14-3-3 protein binding;ATP binding;enzyme binding;GTPase activating protein binding;identical protein binding;kinase activity;nitric-oxide synthase regulator activity;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;protein homodimerization activity;protein kinase activity;protein kinase C binding;protein phosphatase 2A binding;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity","cell-cell junction;ciliary basal body;cytoplasm;cytosol;microtubule cytoskeleton;mitochondrion;nucleoplasm;nucleus;plasma membrane;postsynapse;protein complex;spindle;vesicle","Acute myeloid leukemia;Adipocytokine signaling pathway;Adrenergic signaling in cardiomyocytes;AGE-RAGE signaling pathway in diabetic complications;AMPK signaling pathway;Apelin signaling pathway;Apoptosis;Autophagy - animal;B cell receptor signaling pathway;Breast cancer;cAMP signaling pathway;Carbohydrate digestion and absorption;Cellular senescence;Central carbon metabolism in cancer;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;C-type lectin receptor signaling pathway;Dopaminergic synapse;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;Epstein-Barr virus infection;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Glucagon signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Insulin resistance;Insulin signaling pathway;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Longevity regulating pathway;Longevity regulating pathway - multiple species;MAPK signaling pathway;Measles;Melanoma;mTOR signaling pathway;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Non-small cell lung cancer;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Platelet activation;Platinum drug resistance;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Signaling pathways regulating pluripotency of stem cells;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid hormone signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;VEGF signaling pathway;Yersinia infection",null,null,2,2,2,"6.2","6.2","6.2","55.686",0,"5.1243",38463000,5,"1.08332","0.308317","-0.804888","-3.26137","sp|P31749|AKT1_HUMAN;tr|G3V3K5|G3V3K5_HUMAN","sp|P31749|AKT1_HUMAN;tr|G3V3K5|G3V3K5_HUMAN",889,"P31749","AKT1_HUMAN","RAC-alpha serine/threonine-protein kinase",null,"AKT1"]
["19.8977","19.6616","20.8798","20.2926",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial membrane;mitochondrial respiratory chain complex I","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,1,1,1,"21.2","21.2","21.2","10.921",0,"6.0967",62670000,11,"0.900995","0.299793","-0.806511","-2.54853","sp|O43678|NDUA2_HUMAN","sp|O43678|NDUA2_HUMAN",256,"O43678","NDUA2_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2",null,"NDUFA2"]
["20.917","20.3575","21.4877","21.402",{"$nulls":3},"apoptotic process;cellular protein metabolic process;cellular response to glucose stimulus;cellular response to organic cyclic compound;myoblast differentiation;negative regulation of cell-substrate adhesion;negative regulation of neuron projection development;plasma cell differentiation;positive regulation of erythrocyte aggregation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of viral entry into host cell;post-translational protein modification;regulation of apoptotic process;response to axon injury;response to drug;response to isolation stress;T cell costimulation","lactose binding;laminin binding;protein homodimerization activity;RNA binding;signal transducer activity","cell surface;cytoplasm;cytosol;endoplasmic reticulum lumen;extracellular exosome;extracellular matrix;extracellular region;extracellular space;intracellular;nucleus;proteinaceous extracellular matrix",{"$nulls":3},3,3,3,"28.9","28.9","28.9","14.716",0,"57.418",198710000,21,"0.982956","0.29807","-0.807626","-2.85352","sp|P09382|LEG1_HUMAN","sp|P09382|LEG1_HUMAN",581,"P09382","LEG1_HUMAN","Galectin-1","al-1","LGALS1"]
["14.8708","15.0334","15.857","15.6634",{"$nulls":3},"cargo loading into vesicle;cytokinesis;cytoskeleton-dependent intracellular transport;endosome to lysosome transport;Golgi to plasma membrane protein transport;intracellular protein transport;melanosome organization;microtubule-based movement;plus-end-directed vesicle transport along microtubule","ATP binding;ATPase activity;microtubule binding;microtubule motor activity","centrosome;endosome membrane;kinesin complex;microtubule;midbody;trans-Golgi network membrane",{"$nulls":3},2,2,2,"1.6","1.6","1.6","202.31",0,"12.954",38063000,9,"1.62681","0.327069","-0.808101","-6.39154","sp|Q9H1H9|KI13A_HUMAN;tr|E7ERX9|E7ERX9_HUMAN;tr|H0Y9Z7|H0Y9Z7_HUMAN;tr|H0Y307|H0Y307_HUMAN;sp|Q9NQT8|KI13B_HUMAN","sp|Q9H1H9|KI13A_HUMAN;tr|E7ERX9|E7ERX9_HUMAN;tr|H0Y9Z7|H0Y9Z7_HUMAN;tr|H0Y307|H0Y307_HUMAN;sp|Q9NQT8|KI13B_HUMAN",2570,"Q9H1H9","KI13A_HUMAN","Kinesin-like protein KIF13A",null,"KIF13A"]
["20.0663","19.9319","20.7946","20.8201",{"$nulls":3},"cell cycle;cell division","RNA binding","cytoplasm;microtubule organizing center;midbody",{"$nulls":3},3,3,3,"14.3","14.3","14.3","25.835",0,"7.2787",157150000,8,"2.14934","0.410828","-0.808285","-11.8127","sp|Q96CT7|CC124_HUMAN","sp|Q96CT7|CC124_HUMAN",2251,"Q96CT7","CC124_HUMAN","Coiled-coil domain-containing protein 124",null,"CCDC124"]
["19.5406","19.4403","20.5321","20.0668",{"$nulls":3},"'de novo' pyrimidine nucleobase biosynthetic process;glutamine metabolic process","amino acid binding;aspartate carbamoyltransferase activity;ATP binding;carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;metal ion binding","nucleoplasm",{"$nulls":3},20,20,20,"14.6","14.6","14.6","236.02",0,"122.39",1225300000,72,"1.11515","0.311435","-0.809019","-3.39942","tr|F8VPD4|F8VPD4_HUMAN;sp|P27708|PYR1_HUMAN;tr|H7C2E4|H7C2E4_HUMAN","tr|F8VPD4|F8VPD4_HUMAN;sp|P27708|PYR1_HUMAN",827,"F8VPD4","F8VPD4_HUMAN",null,null,"CAD"]
["16.711","16.5907","17.7137","17.2071",{"$nulls":3},"anatomical structure morphogenesis;cell differentiation;double-strand break repair;histone dephosphorylation;multicellular organism development;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;positive regulation of DNA repair;regulation of transcription, DNA-templated;response to ionizing radiation;transcription, DNA-templated;visual perception","metal ion binding;protein tyrosine phosphatase activity","centrosome;cytoplasm;nucleoplasm;nucleus;transcription factor complex",{"$nulls":3},1,1,1,"3.3","3.3","3.3","62.662","0.00076453","2.972",26339000,9,"1.04718","0.304887","-0.809573","-3.10981","sp|Q99504|EYA3_HUMAN","sp|Q99504|EYA3_HUMAN",2377,"Q99504","EYA3_HUMAN","Eyes absent homolog 3",null,"EYA3"]
["18.37","17.9946","18.996","18.9903",{"$nulls":9},1,1,1,"8.2","8.2","8.2","17.091",0,"11.553",39095000,8,"1.30413","0.334724","-0.810853","-4.31927","tr|A0A087WVQ2|A0A087WVQ2_HUMAN;tr|I3L0Y2|I3L0Y2_HUMAN;tr|I3L4Q4|I3L4Q4_HUMAN;sp|Q9BUL5|PHF23_HUMAN","tr|A0A087WVQ2|A0A087WVQ2_HUMAN;tr|I3L0Y2|I3L0Y2_HUMAN;tr|I3L4Q4|I3L4Q4_HUMAN;sp|Q9BUL5|PHF23_HUMAN",2456,"A0A087WVQ2","A0A087WVQ2_HUMAN",null,null,"PHF23"]
["20.9356","20.9005","22.0178","21.4411",{"$nulls":4},"RNA binding",{"$nulls":4},19,19,18,"18.1","18.1","17.4","158.64",0,"213.2",2048600000,107,"0.971208","0.297567","-0.811398","-2.80834","tr|E7EX73|E7EX73_HUMAN;tr|E9PGM1|E9PGM1_HUMAN;tr|E7EUU4|E7EUU4_HUMAN;sp|Q04637|IF4G1_HUMAN;tr|A0A0A0MR52|A0A0A0MR52_HUMAN;tr|H7C044|H7C044_HUMAN;tr|C9J6B6|C9J6B6_HUMAN;tr|C9JF13|C9JF13_HUMAN;tr|C9J2Z7|C9J2Z7_HUMAN;tr|C9K073|C9K073_HUMAN;tr|H7C0V6|H7C0V6_HUMAN;tr|C9JWH7|C9JWH7_HUMAN;tr|C9J556|C9J556_HUMAN;tr|C9JSU8|C9JSU8_HUMAN;tr|C9JWW9|C9JWW9_HUMAN","tr|E7EX73|E7EX73_HUMAN;tr|E9PGM1|E9PGM1_HUMAN;tr|E7EUU4|E7EUU4_HUMAN;sp|Q04637|IF4G1_HUMAN;tr|A0A0A0MR52|A0A0A0MR52_HUMAN",1443,"E7EX73","E7EX73_HUMAN",null,null,"EIF4G1"]
["15.7708","15.3224","16.8348","15.8864",{"$nulls":3},"mRNA splicing, via spliceosome;RNA metabolic process","RNA binding","cytosol;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus",{"$nulls":3},5,1,1,"16.3","3.8","3.8","49.263",0,"3.6217",10335000,1,"0.583587","0.452452","-0.814012","-1.55191","sp|P55795|HNRH2_HUMAN","sp|P55795|HNRH2_HUMAN",1213,"P55795","HNRH2_HUMAN","Heterogeneous nuclear ribonucleoprotein H2","nRNP H2","HNRNPH2"]
["19.5601","19.6784","20.1347","20.7336",{"$nulls":3},"respiratory electron transport chain","oxidoreductase activity, acting on NAD(P)H","mitochondrial inner membrane",{"$nulls":3},1,1,1,"12.9","12.9","12.9","7.8423",0,"3.4593",32821000,2,"0.934374","0.297565","-0.814886","-2.66991","tr|F8WAS3|F8WAS3_HUMAN;tr|C9IZN5|C9IZN5_HUMAN;tr|A0A087X1G1|A0A087X1G1_HUMAN;tr|H7BYD0|H7BYD0_HUMAN;sp|Q16718|NDUA5_HUMAN","tr|F8WAS3|F8WAS3_HUMAN;tr|C9IZN5|C9IZN5_HUMAN;tr|A0A087X1G1|A0A087X1G1_HUMAN;tr|H7BYD0|H7BYD0_HUMAN;sp|Q16718|NDUA5_HUMAN",1752,"F8WAS3","F8WAS3_HUMAN",null,null,"NDUFA5"]
["18.5274","18.4567","19.5918","19.0238",{"$nulls":9},1,1,1,"10.9","10.9","10.9","12.946","0.0014045","2.3008",37688000,2,"0.982088","0.296","-0.815752","-2.85016","tr|E7EPW2|E7EPW2_HUMAN;sp|P82663|RT25_HUMAN","tr|E7EPW2|E7EPW2_HUMAN;sp|P82663|RT25_HUMAN",1378,"E7EPW2","E7EPW2_HUMAN",null,null,"MRPS25"]
["20.4656","20.0869","21.5704","20.6142",{"$nulls":3},"activation of MAPKK activity;cellular response to endothelin;cellular response to insulin-like growth factor stimulus;cellular response to nerve growth factor stimulus;cellular response to nitric oxide;cellular response to transforming growth factor beta stimulus;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;negative regulation of cell motility;negative regulation of natural killer cell mediated cytotoxicity;negative regulation of wound healing;positive regulation of cell growth;positive regulation of smooth muscle cell migration;positive regulation of substrate adhesion-dependent cell spreading;regulation of actin cytoskeleton organization;regulation of cell shape;regulation of GTPase activity;regulation of protein binding;regulation of Rac protein signal transduction;regulation of signal transduction;regulation of transcription from RNA polymerase II promoter;response to cholecystokinin;response to hepatocyte growth factor;response to hydrogen peroxide;response to yeast;SH2 domain-mediated complex assembly;vascular endothelial growth factor receptor signaling pathway","cytoskeletal protein binding;ephrin receptor binding;insulin-like growth factor receptor binding;phosphotyrosine residue binding;protein phosphorylated amino acid binding;protein self-association;protein tyrosine kinase binding;scaffold protein binding;SH2 domain binding;SH3 domain binding;SH3/SH2 adaptor activity","actin cytoskeleton;cytoplasm;cytosol;extracellular exosome;membrane raft;nucleus;plasma membrane;protein complex","Bacterial invasion of epithelial cells;Chemokine signaling pathway;Chronic myeloid leukemia;ErbB signaling pathway;Fc gamma R-mediated phagocytosis;Focal adhesion;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Insulin signaling pathway;MAPK signaling pathway;MicroRNAs in cancer;Neurotrophin signaling pathway;Pathways in cancer;Rap1 signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Shigellosis;Yersinia infection",null,null,6,6,6,28,28,28,"33.83",0,"60.384",303010000,32,"0.596145","0.441053","-0.816028","-1.58696","sp|P46108|CRK_HUMAN;tr|I3L297|I3L297_HUMAN","sp|P46108|CRK_HUMAN;tr|I3L297|I3L297_HUMAN",1024,"P46108","CRK_HUMAN","Adapter molecule crk",null,"CRK"]
["18.863","18.5228","19.6188","19.4013",{"$nulls":3},"cholesterol biosynthetic process;dimethylallyl diphosphate biosynthetic process;isopentenyl diphosphate biosynthetic process;isoprenoid biosynthetic process;regulation of cholesterol biosynthetic process","hydrolase activity;isopentenyl-diphosphate delta-isomerase activity;magnesium ion binding;manganese ion binding;metal ion binding","cytosol;peroxisome","Metabolic pathways;Terpenoid backbone biosynthesis",null,null,3,3,3,"18.5","18.5","18.5","26.319",0,"8.9066",95213000,11,"1.25194","0.325435","-0.817151","-4.04683","sp|Q13907|IDI1_HUMAN;tr|C9JKM8|C9JKM8_HUMAN","sp|Q13907|IDI1_HUMAN",1591,"Q13907","IDI1_HUMAN","Isopentenyl-diphosphate Delta-isomerase 1",null,"IDI1"]
["14.1636","14.021","15.564","14.255",{"$nulls":3},"ATP-dependent chromatin remodeling;beta-catenin-TCF complex assembly;chromatin organization;chromatin remodeling;covalent chromatin modification;interleukin-7-mediated signaling pathway;negative regulation of androgen receptor signaling pathway;negative regulation of cell growth;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle;negative regulation of transcription, DNA-templated;nervous system development;neural retina development;nucleosome disassembly;positive regulation by host of viral transcription;positive regulation of DNA binding transcription factor activity;positive regulation of glucose mediated signaling pathway;positive regulation of pri-miRNA transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;positive regulation of transcription, DNA-templated;positive regulation of Wnt signaling pathway;regulation of transcription from RNA polymerase II promoter","androgen receptor binding;ATP binding;DNA polymerase binding;DNA-dependent ATPase activity;helicase activity;lysine-acetylated histone binding;p53 binding;protein N-terminus binding;RNA polymerase I CORE element sequence-specific DNA binding;RNA polymerase II transcription coactivator activity;Tat protein binding;transcription coactivator activity;transcription corepressor activity;transcription factor binding","extracellular space;membrane;nBAF complex;npBAF complex;nuclear chromatin;nucleolus;nucleoplasm;nucleus;protein complex;SWI/SNF complex","Hepatocellular carcinoma;Thermogenesis",null,null,2,2,2,"1.8","1.8","1.8","184.64","0.00039746","3.3224",18272000,4,"0.46806","0.535116","-0.817187","-1.24121","sp|P51532|SMCA4_HUMAN;tr|Q9HBD4|Q9HBD4_HUMAN;tr|A0A0A0MT49|A0A0A0MT49_HUMAN;tr|K7EP28|K7EP28_HUMAN","sp|P51532|SMCA4_HUMAN;tr|Q9HBD4|Q9HBD4_HUMAN;tr|A0A0A0MT49|A0A0A0MT49_HUMAN;tr|K7EP28|K7EP28_HUMAN",1134,"P51532","SMCA4_HUMAN","Transcription activator BRG1",null,"SMARCA4"]
["15.8573","15.6255","17.2812","15.8361",{"$nulls":9},1,1,1,2,2,2,"73.476",0,"3.591",30023000,3,"0.419911","0.594878","-0.817238","-1.11674","tr|G5E9W3|G5E9W3_HUMAN;sp|Q9UKF6|CPSF3_HUMAN","tr|G5E9W3|G5E9W3_HUMAN;sp|Q9UKF6|CPSF3_HUMAN",2868,"G5E9W3","G5E9W3_HUMAN"]
["17.7224",1,"19.36",1,{"$nulls":3},"protein import into mitochondrial matrix;protein targeting to mitochondrion","P-P-bond-hydrolysis-driven protein transmembrane transporter activity","integral component of mitochondrial inner membrane;mitochondrial inner membrane;mitochondrial inner membrane presequence translocase complex",{"$nulls":3},2,2,2,"20.3","20.3","20.3","18.273",0,"5.1546",13528000,2,"0.020714","0.975498","-0.818781","-0.0659403","sp|O60830|TI17B_HUMAN;tr|V9GYS0|V9GYS0_HUMAN;tr|V9GYU0|V9GYU0_HUMAN","sp|O60830|TI17B_HUMAN;tr|V9GYS0|V9GYS0_HUMAN;tr|V9GYU0|V9GYU0_HUMAN",309,"O60830","TI17B_HUMAN","Mitochondrial import inner membrane translocase subunit Tim17-B",null,"TIMM17B"]
["16.0525","16.1473","17.0223","16.8153",{"$nulls":3},"mitochondrial fusion","GTP binding;GTPase activity","integral component of membrane;mitochondrial outer membrane",{"$nulls":3},1,1,1,2,2,2,"56.235","0.006006","1.866",26186000,1,"1.72625","0.355119","-0.818835","-7.19346","tr|H7C5H5|H7C5H5_HUMAN;tr|A0A0C4DFN1|A0A0C4DFN1_HUMAN;sp|Q8IWA4|MFN1_HUMAN","tr|H7C5H5|H7C5H5_HUMAN;tr|A0A0C4DFN1|A0A0C4DFN1_HUMAN;sp|Q8IWA4|MFN1_HUMAN",2011,"H7C5H5","H7C5H5_HUMAN",null,null,"MFN1"]
["19.0896","19.0219","19.8662","19.8845",{"$nulls":3},"mRNA splicing, via spliceosome","nucleic acid binding","nucleoplasm",{"$nulls":3},6,6,6,"19.5","19.5","19.5","52.228",0,"70.426",189890000,23,"2.73891","0.569926","-0.819597","-23.381","sp|Q92917|GPKOW_HUMAN","sp|Q92917|GPKOW_HUMAN",2203,"Q92917","GPKOW_HUMAN","G-patch domain and KOW motifs-containing protein",null,"GPKOW"]
["15.5777","16.436","17.5235","16.1323",{"$nulls":3},"histone H3-K36 methylation;histone H3-K4 methylation;peptidyl-lysine dimethylation;peptidyl-lysine monomethylation;peptidyl-lysine trimethylation;positive regulation of muscle cell differentiation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;transcription, DNA-templated","histone methyltransferase activity (H3-K36 specific);histone methyltransferase activity (H3-K4 specific);histone-lysine N-methyltransferase activity;RNA polymerase II activating transcription factor binding;transcription coactivator activity","nuclear chromatin;nucleoplasm","Lysine degradation",null,null,3,3,3,"8.4","8.4","8.4","67.256",0,"9.9765",44937000,19,"0.375788","0.647898","-0.821012","-1.00447","sp|Q86TU7|SETD3_HUMAN","sp|Q86TU7|SETD3_HUMAN",1974,"Q86TU7","SETD3_HUMAN","Histone-lysine N-methyltransferase setd3",null,"SETD3"]
["18.9415","17.5072","19.7046","18.3875",{"$nulls":9},1,1,1,"22.8","22.8","22.8","6.3823","0.0011202","2.7779",16756000,3,"0.311998","0.714405","-0.821749","-0.843992","tr|H3BUW6|H3BUW6_HUMAN;tr|H3BN64|H3BN64_HUMAN;tr|H3BRM1|H3BRM1_HUMAN;tr|H3BRF9|H3BRF9_HUMAN;sp|Q96K21|ANCHR_HUMAN","tr|H3BUW6|H3BUW6_HUMAN;tr|H3BN64|H3BN64_HUMAN;tr|H3BRM1|H3BRM1_HUMAN;tr|H3BRF9|H3BRF9_HUMAN;sp|Q96K21|ANCHR_HUMAN",2313,"H3BUW6","H3BUW6_HUMAN",null,null,"ZFYVE19"]
["21.8086","21.398","22.7071","22.143",{"$nulls":3},"cellular hyperosmotic response;cellular response to glucose starvation;cellular response to mechanical stimulus;cerebral cortex development;female pregnancy;glucose transmembrane transport;glucose transport;lactose biosynthetic process;L-ascorbic acid metabolic process;protein complex assembly;regulation of glucose transport;regulation of insulin secretion;response to insulin;response to Thyroglobulin triiodothyronine","dehydroascorbic acid transmembrane transporter activity;D-glucose transmembrane transporter activity;glucose transmembrane transporter activity;identical protein binding;kinase binding;protein self-association;xenobiotic transmembrane transporter activity","apical plasma membrane;basolateral plasma membrane;blood microparticle;caveola;cortical actin cytoskeleton;cytosol;extracellular exosome;female pronucleus;Golgi membrane;integral component of plasma membrane;intercalated disc;melanosome;membrane;midbody;plasma membrane;sarcolemma;Z disc","Adipocytokine signaling pathway;Bile secretion;Central carbon metabolism in cancer;Glucagon signaling pathway;HIF-1 signaling pathway;Human T-cell leukemia virus 1 infection;Insulin resistance;Insulin secretion;Pathways in cancer;Renal cell carcinoma;Thyroid hormone signaling pathway",null,null,3,3,3,"7.7","7.7","7.7","54.083",0,"32.174",689830000,19,"0.845809","0.308692","-0.821807","-2.35582","sp|P11166|GTR1_HUMAN","sp|P11166|GTR1_HUMAN",618,"P11166","GTR1_HUMAN","Solute carrier family 2, facilitated glucose transporter member 1",null,"SLC2A1"]
["18.3562","18.2903","19.5739","18.7171",{"$nulls":9},2,2,2,"23.5","23.5","23.5","16.852",0,"5.5804",17422000,3,"0.708196","0.362207","-0.822207","-1.91353","tr|Q5TB19|Q5TB19_HUMAN;tr|E9PLC4|E9PLC4_HUMAN;sp|Q9BTT0|AN32E_HUMAN","tr|Q5TB19|Q5TB19_HUMAN;tr|E9PLC4|E9PLC4_HUMAN;sp|Q9BTT0|AN32E_HUMAN",2447,"Q5TB19","Q5TB19_HUMAN"]
["20.0522","20.626","21.1164","21.2063",{"$nulls":3},"positive regulation of translation;regulation of translation;RNA processing","RNA binding","cytoplasm;dendrite;nucleolus;nucleoplasm;nucleus",{"$nulls":3},2,2,2,28,28,28,"17.17",0,"102.81",130780000,11,"0.977162","0.294818","-0.822263","-2.83117","sp|P98179|RBM3_HUMAN","sp|P98179|RBM3_HUMAN",1397,"P98179","RBM3_HUMAN","RNA-binding protein 3",null,"RBM3"]
["20.7209","20.9621","21.5676","21.7604",{"$nulls":3},"translational initiation","translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;extracellular exosome","RNA transport",null,null,5,5,5,"24.9","24.9","24.9","36.501",0,"18.419",489900000,21,"1.4754","0.327438","-0.822486","-5.32821","sp|Q13347|EIF3I_HUMAN;tr|Q5TFK1|Q5TFK1_HUMAN","sp|Q13347|EIF3I_HUMAN",1545,"Q13347","EIF3I_HUMAN","Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008}","IF3i {ECO:0000255|HAMAP-Rule:MF_03008}","EIF3I"]
["18.0027","17.5371","19.1886","18.0014",{"$nulls":3},"vesicle-mediated transport",null,"TRAPP complex",{"$nulls":3},2,2,2,"26.5","26.5","26.5","13.021",0,"3.6275",24790000,5,"0.488189","0.523017","-0.825076","-1.294","tr|G3V1A0|G3V1A0_HUMAN;tr|G5EA23|G5EA23_HUMAN;tr|J3KP27|J3KP27_HUMAN;sp|Q9Y296|TPPC4_HUMAN;tr|E9PN70|E9PN70_HUMAN;tr|E9PKS9|E9PKS9_HUMAN;tr|E9PQE8|E9PQE8_HUMAN","tr|G3V1A0|G3V1A0_HUMAN;tr|G5EA23|G5EA23_HUMAN;tr|J3KP27|J3KP27_HUMAN;sp|Q9Y296|TPPC4_HUMAN;tr|E9PN70|E9PN70_HUMAN;tr|E9PKS9|E9PKS9_HUMAN;tr|E9PQE8|E9PQE8_HUMAN",2947,"G3V1A0","G3V1A0_HUMAN",null,null,"TRAPPC4"]
["16.391","16.5351","18.167","16.4099",{"$nulls":3},"regulation of microtubule motor activity",{"$nulls":5},1,1,1,"8.7","8.7","8.7","15.143",0,"5.1546",16391000,5,"0.348765","0.687317","-0.825358","-0.936309","tr|I3L3G9|I3L3G9_HUMAN;tr|I3L2S8|I3L2S8_HUMAN;tr|J3KRK9|J3KRK9_HUMAN;tr|J3QL85|J3QL85_HUMAN;tr|A6NIZ0|A6NIZ0_HUMAN;tr|X5DR54|X5DR54_HUMAN;sp|Q9GZM8|NDEL1_HUMAN;sp|Q9NXR1|NDE1_HUMAN","tr|I3L3G9|I3L3G9_HUMAN;tr|I3L2S8|I3L2S8_HUMAN;tr|J3KRK9|J3KRK9_HUMAN;tr|J3QL85|J3QL85_HUMAN;tr|A6NIZ0|A6NIZ0_HUMAN;tr|X5DR54|X5DR54_HUMAN;sp|Q9GZM8|NDEL1_HUMAN;sp|Q9NXR1|NDE1_HUMAN",2535,"I3L3G9","I3L3G9_HUMAN",null,null,"NDE1"]
["17.8551","17.738","18.9407","18.307",{"$nulls":4},"GTP binding;GTPase activity",{"$nulls":4},2,2,2,"12.6","12.6","12.6","20.42",0,"4.671",67225000,9,"0.906251","0.295699","-0.827305","-2.56739","tr|A0A087X163|A0A087X163_HUMAN;sp|Q9NP72|RAB18_HUMAN;tr|Q5W0J0|Q5W0J0_HUMAN;tr|H0Y6T8|H0Y6T8_HUMAN","tr|A0A087X163|A0A087X163_HUMAN;sp|Q9NP72|RAB18_HUMAN;tr|Q5W0J0|Q5W0J0_HUMAN;tr|H0Y6T8|H0Y6T8_HUMAN",2654,"A0A087X163","A0A087X163_HUMAN",null,null,"RAB18"]
["21.1789","21.4822","22.282","22.034",{"$nulls":3},"cellular lipid metabolic process;cellular protein metabolic process;leukotriene biosynthetic process;leukotriene metabolic process;neutrophil degranulation;peptide catabolic process","aminopeptidase activity;epoxide hydrolase activity;leukotriene-A4 hydrolase activity;metalloaminopeptidase activity;peptidase activity;peptide binding;RNA binding;zinc ion binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;nucleus;tertiary granule lumen","Arachidonic acid metabolism;Metabolic pathways",null,null,14,14,14,"33.1","33.1","33.1","69.284",0,"94.232",1116100000,75,"1.28619","0.329009","-0.827414","-4.22391","sp|P09960|LKHA4_HUMAN;tr|B4DEH5|B4DEH5_HUMAN","sp|P09960|LKHA4_HUMAN",597,"P09960","LKHA4_HUMAN","Leukotriene A-4 hydrolase","TA-4 hydrolase","LTA4H"]
["25.0929","24.4886","26.2841","24.9534",{"$nulls":3},"negative regulation of cell proliferation;negative regulation of DNA replication;neutrophil degranulation;signal transduction","cadherin binding involved in cell-cell adhesion;calcium ion binding;calcium-dependent protein binding;protein homodimerization activity;S100 protein binding","cell-cell adherens junction;cytoplasm;extracellular exosome;extracellular region;extracellular space;nucleus;ruffle;secretory granule lumen",{"$nulls":3},4,4,4,39,39,39,"11.74",0,"49.995",2004500000,27,"0.426307","0.588535","-0.82804","-1.13315","sp|P31949|S10AB_HUMAN","sp|P31949|S10AB_HUMAN",899,"P31949","S10AB_HUMAN","Protein S100-A11",null,"S100A11"]
["17.3772","17.2723","18.348","17.9583",{"$nulls":3},"activation of MAPKK activity;axon guidance;calcium-mediated signaling;cell migration;cellular response to epidermal growth factor stimulus;epidermal growth factor receptor signaling pathway;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;in utero embryonic development;inositol phosphate metabolic process;leukocyte migration;phospholipid catabolic process;positive regulation of angiogenesis;positive regulation of blood vessel endothelial cell migration;positive regulation of epithelial cell migration;positive regulation of release of sequestered calcium ion into cytosol;signal transduction;T cell receptor signaling pathway;viral process","calcium ion binding;glutamate receptor binding;neurotrophin TRKA receptor binding;phosphatidylinositol phospholipase C activity;phospholipase C activity;protein kinase binding;receptor tyrosine kinase binding;signal transducer activity, downstream of receptor","cell projection;cell-cell junction;COP9 signalosome;cytoplasm;cytosol;lamellipodium;plasma membrane;ruffle","AGE-RAGE signaling pathway in diabetic complications;Axon guidance;Calcium signaling pathway;Choline metabolism in cancer;EGFR tyrosine kinase inhibitor resistance;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glioma;Hepatocellular carcinoma;HIF-1 signaling pathway;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Inositol phosphate metabolism;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Metabolic pathways;MicroRNAs in cancer;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;NF-kappa B signaling pathway;Non-small cell lung cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid hormone signaling pathway;VEGF signaling pathway;Vibrio cholerae infection;Yersinia infection",null,null,5,5,5,"6.6","6.6","6.6","148.53",0,"12.882",192380000,19,"1.26348","0.32764","-0.828395","-4.10578","sp|P19174|PLCG1_HUMAN","sp|P19174|PLCG1_HUMAN",727,"P19174","PLCG1_HUMAN","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1",null,"PLCG1"]
["20.1533","19.6779","21.0048","20.4876",{"$nulls":3},"cell separation after cytokinesis;endosomal transport;macroautophagy;membrane invagination;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of autophagosome assembly;negative regulation of neuron death;nucleus organization;plasma membrane tubulation;posttranslational protein targeting to endoplasmic reticulum membrane;protein homooligomerization;protein polymerization;vacuolar transport;vesicle budding from membrane;viral budding via host ESCRT complex;viral life cycle","ATPase binding;identical protein binding;lipid binding;protein homodimerization activity","cytoplasm;cytoplasmic side of plasma membrane;cytoplasmic vesicle membrane;cytosol;ESCRT III complex;extracellular exosome;late endosome membrane;membrane coat;midbody;nucleus","Endocytosis;Necroptosis",null,null,4,4,4,"18.9","18.9","18.9","25.098",0,"9.7172",178740000,19,"0.84844","0.308571","-0.830606","-2.36479","sp|Q9BY43|CHM4A_HUMAN;tr|E9PQI5|E9PQI5_HUMAN;tr|E9PQ80|E9PQ80_HUMAN;tr|E9PSI1|E9PSI1_HUMAN;tr|H0YI89|H0YI89_HUMAN;tr|H0YIN6|H0YIN6_HUMAN","sp|Q9BY43|CHM4A_HUMAN;tr|E9PQI5|E9PQI5_HUMAN;tr|E9PQ80|E9PQ80_HUMAN;tr|E9PSI1|E9PSI1_HUMAN;tr|H0YI89|H0YI89_HUMAN",2505,"Q9BY43","CHM4A_HUMAN","Charged multivesicular body protein 4a",null,"CHMP4A"]
["18.7605","19.1177","20.826","18.7154",{"$nulls":3},"L-methionine salvage from methylthioadenosine","acireductone dioxygenase [iron(II)-requiring] activity;metal ion binding;oxidoreductase activity","cytoplasm;cytosol;nucleus;plasma membrane","Cysteine and methionine metabolism;Metabolic pathways",null,null,3,3,3,"19.6","19.6","19.6","21.498","0.00040404","3.4385",108320000,4,"0.285244","0.745919","-0.83157","-0.77692","sp|Q9BV57|MTND_HUMAN","sp|Q9BV57|MTND_HUMAN",2467,"Q9BV57","MTND_HUMAN","1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase {ECO:0000255|HAMAP-Rule:MF_03154}",null,"ADI1"]
["23.1694","23.1584","24.2061","23.7849",{"$nulls":3},"cell proliferation;cellular response to hydrogen peroxide;cellular response to UV;DNA damage response, detection of DNA damage;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA ligation;epithelial cell differentiation;error-free translesion synthesis;error-prone translesion synthesis;estrous cycle;heart development;leading strand elongation;liver regeneration;mismatch repair;mitotic telomere maintenance via semi-conservative replication;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of deoxyribonuclease activity;positive regulation of DNA repair;positive regulation of DNA replication;protein sumoylation;protein ubiquitination;regulation of transcription involved in G1/S transition of mitotic cell cycle;replication fork processing;response to cadmium ion;response to dexamethasone;response to estradiol;response to L-glutamate;telomere maintenance;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","chromatin binding;damaged DNA binding;dinucleotide insertion or deletion binding;DNA polymerase binding;DNA polymerase processivity factor activity;enzyme binding;estrogen receptor binding;histone acetyltransferase binding;identical protein binding;MutLalpha complex binding;purine-specific mismatch base pair DNA N-glycosylase activity;receptor tyrosine kinase binding","centrosome;DNA replication factor C complex;extracellular exosome;nuclear body;nuclear chromosome, telomeric region;nuclear replication fork;nucleoplasm;nucleus;PCNA complex;PCNA-p21 complex;replication fork;replisome","Base excision repair;Cell cycle;DNA replication;Hepatitis B;Mismatch repair;Nucleotide excision repair;Tight junction",null,null,9,9,9,"51.3","51.3","51.3","28.768",0,"267.55",2304700000,102,"1.23205","0.317432","-0.831624","-3.9469","sp|P12004|PCNA_HUMAN","sp|P12004|PCNA_HUMAN",639,"P12004","PCNA_HUMAN","Proliferating cell nuclear antigen","CNA","PCNA"]
["17.0216","17.1938","18.1848","17.694",{"$nulls":3},"cytoplasmic mRNA processing body assembly;deadenylation-dependent decapping of nuclear-transcribed mRNA;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay","poly(G) binding;poly(U) RNA binding;RNA binding","cytoplasmic ribonucleoprotein granule;cytosol;nuclear speck;P-body;PML body","RNA degradation",null,null,4,4,4,"8.3","8.3","8.3","86.849",0,"7.1972",95057000,7,"1.0683","0.302367","-0.831672","-3.1977","sp|Q86TB9|PATL1_HUMAN","sp|Q86TB9|PATL1_HUMAN",1971,"Q86TB9","PATL1_HUMAN","Protein PAT1 homolog 1",null,"PATL1"]
["16.072","15.9501","16.6257","17.0597",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding",{"$nulls":4},7,1,1,"21.9","3.7","3.7","39.933","0.003111","2.1501",23136000,3,"1.17892","0.318197","-0.831676","-3.68985","tr|M0QZM1|M0QZM1_HUMAN","tr|M0QZM1|M0QZM1_HUMAN",3114,"M0QZM1","M0QZM1_HUMAN",null,null,"HNRNPM"]
[1,"18.1089","19.7777",1,{"$nulls":9},2,2,2,"20.3","20.3","20.3","24.061",0,"9.8169",21010000,2,"0.0206346","0.974273","-0.834397","-0.0656928","tr|E9PPG9|E9PPG9_HUMAN;sp|P78406|RAE1L_HUMAN;tr|E9PQ57|E9PQ57_HUMAN;tr|B0QZ37|B0QZ37_HUMAN;tr|B0QZ36|B0QZ36_HUMAN","tr|E9PPG9|E9PPG9_HUMAN;sp|P78406|RAE1L_HUMAN;tr|E9PQ57|E9PQ57_HUMAN;tr|B0QZ37|B0QZ37_HUMAN;tr|B0QZ36|B0QZ36_HUMAN",1371,"E9PPG9","E9PPG9_HUMAN",null,null,"RAE1"]
["19.9256","19.8802","20.7421","20.7325",{"$nulls":3},"carbohydrate phosphorylation;cellular carbohydrate metabolic process;fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;glycerol metabolic process;innate immune response;negative regulation of MDA-5 signaling pathway;regulation of innate immune response","ATP binding;FAD-AMP lyase (cyclizing) activity;glycerone kinase activity;metal ion binding;triokinase activity","cytosol;extracellular exosome;nucleus","Carbon metabolism;Fructose and mannose metabolism;Glycerolipid metabolism;Metabolic pathways;RIG-I-like receptor signaling pathway",null,null,8,8,8,"20.2","20.2","20.2","58.946",0,"46.999",378430000,24,"3.11202","0.489391","-0.834409","-35.9547","sp|Q3LXA3|TKFC_HUMAN;tr|A0A087WUL0|A0A087WUL0_HUMAN;tr|H0YCY6|H0YCY6_HUMAN;tr|I3L252|I3L252_HUMAN","sp|Q3LXA3|TKFC_HUMAN;tr|A0A087WUL0|A0A087WUL0_HUMAN;tr|H0YCY6|H0YCY6_HUMAN;tr|I3L252|I3L252_HUMAN",1780,"Q3LXA3","TKFC_HUMAN","Triokinase/FMN cyclase {ECO:0000312|HGNC:HGNC:24552}",null,"TKFC"]
["18.4607","19.2763","19.9671","19.439",{"$nulls":3},"anatomical structure morphogenesis;mRNA transport;negative regulation of translation;regulation of cytokine biosynthetic process;regulation of mRNA stability","mRNA 3'-UTR binding;mRNA 5'-UTR binding;RNA binding;translation regulator activity","cytoplasm;cytoskeleton;cytosol;nucleus",{"$nulls":3},9,8,8,"21.5","19.4","19.4","66.121",0,"24.554",206500000,45,"0.642149","0.401684","-0.834557","-1.71789","sp|Q9Y6M1|IF2B2_HUMAN;tr|F8W930|F8W930_HUMAN","sp|Q9Y6M1|IF2B2_HUMAN;tr|F8W930|F8W930_HUMAN",3054,"Q9Y6M1","IF2B2_HUMAN","Insulin-like growth factor 2 mRNA-binding protein 2","GF2 mRNA-binding protein 2;MP-2","IGF2BP2"]
["21.8383","21.6667","22.8352","22.3394",{"$nulls":3},"protein targeting to mitochondrion","heat shock protein binding","cytosol;integral component of membrane;membrane;mitochondrial outer membrane;nucleoplasm;nucleus",{"$nulls":3},9,9,9,"37.2","37.2","37.2","34.559",0,"127.27",812410000,58,"1.06473","0.304455","-0.83485","-3.18274","sp|Q15785|TOM34_HUMAN","sp|Q15785|TOM34_HUMAN",1722,"Q15785","TOM34_HUMAN","Mitochondrial import receptor subunit TOM34","Tom34","TOMM34"]
["13.6939","13.7209","15.0001","14.0876",{"$nulls":4},"RNA binding;ubiquitin binding;ubiquitin-protein transferase activity;zinc ion binding","cytosol;nucleoplasm",{"$nulls":3},2,2,2,"1.1","1.1","1.1","308.57",0,"4.7961",22283000,3,"0.681269","0.377787","-0.836454","-1.83261","tr|E7EMW7|E7EMW7_HUMAN;sp|O95071|UBR5_HUMAN","tr|E7EMW7|E7EMW7_HUMAN;sp|O95071|UBR5_HUMAN",409,"E7EMW7","E7EMW7_HUMAN",null,null,"UBR5"]
["18.2747","18.0223","19.4023","18.5687",{"$nulls":4},"RNA binding",{"$nulls":4},6,3,3,"17.8","12.9","12.9","58.311",0,"4.5537",74244000,16,"0.710971","0.360734","-0.837014","-1.92197","tr|A0A024R7W5|A0A024R7W5_HUMAN;tr|A0A087X0Q1|A0A087X0Q1_HUMAN;sp|Q7Z739|YTHD3_HUMAN;tr|A0A087WY31|A0A087WY31_HUMAN","tr|A0A024R7W5|A0A024R7W5_HUMAN;tr|A0A087X0Q1|A0A087X0Q1_HUMAN;sp|Q7Z739|YTHD3_HUMAN;tr|A0A087WY31|A0A087WY31_HUMAN",1965,"A0A024R7W5","A0A024R7W5_HUMAN"]
["18.8783","17.9986","19.9285","18.6258",{"$nulls":3},"acetyl-CoA biosynthetic process;cholesterol biosynthetic process;citrate metabolic process;coenzyme A metabolic process;fatty acid biosynthetic process;fatty-acyl-CoA biosynthetic process;lipid biosynthetic process;neutrophil degranulation;oxaloacetate metabolic process;positive regulation of cellular metabolic process","ATP binding;ATP citrate synthase activity;cofactor binding;metal ion binding","azurophil granule lumen;citrate lyase complex;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;plasma membrane","Citrate cycle (TCA cycle);Metabolic pathways",null,null,18,18,18,21,21,21,"120.84",0,"65.474",639450000,67,"0.400476","0.62172","-0.838696","-1.06711","sp|P53396|ACLY_HUMAN;tr|K7ESG8|K7ESG8_HUMAN;tr|K7EIE7|K7EIE7_HUMAN","sp|P53396|ACLY_HUMAN",1179,"P53396","ACLY_HUMAN","ATP-citrate synthase",null,"ACLY"]
["19.3705","19.2785","20.676","19.6522",{"$nulls":3},"mitochondrial translational elongation;regulation of DNA-templated transcription, elongation;regulation of mitochondrial translation;translational elongation","RNA binding;translation elongation factor activity","mitochondrial matrix;mitochondrion;nucleus",{"$nulls":3},4,4,4,"25.5","25.5","25.5","35.39",0,"37.562",116930000,21,"0.612736","0.426032","-0.839627","-1.63371","sp|P43897|EFTS_HUMAN;tr|C9JG32|C9JG32_HUMAN;tr|C9JT21|C9JT21_HUMAN;tr|F8VPA7|F8VPA7_HUMAN;tr|F8VS27|F8VS27_HUMAN","sp|P43897|EFTS_HUMAN",1015,"P43897","EFTS_HUMAN","Elongation factor Ts, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03135}","F-Ts {ECO:0000255|HAMAP-Rule:MF_03135};F-TsMt {ECO:0000255|HAMAP-Rule:MF_03135}","TSFM"]
["16.1445","15.9007","16.9907","16.735",{"$nulls":3},"DNA replication","3'-5' exonuclease activity;DNA binding;DNA-directed DNA polymerase activity;nucleotide binding",{"$nulls":4},2,2,2,"3.3","3.3","3.3","111.68",0,"5.5016",60772000,12,"1.38237","0.335706","-0.840308","-4.75712","tr|M0QZR8|M0QZR8_HUMAN;sp|P28340|DPOD1_HUMAN;tr|M0R2B7|M0R2B7_HUMAN;tr|M0QZB4|M0QZB4_HUMAN","tr|M0QZR8|M0QZR8_HUMAN;sp|P28340|DPOD1_HUMAN;tr|M0R2B7|M0R2B7_HUMAN;tr|M0QZB4|M0QZB4_HUMAN",838,"M0QZR8","M0QZR8_HUMAN","DNA polymerase {ECO:0000256|RuleBase:RU000442}",null,"POLD1"]
["18.255","17.6297","19.394","18.1808",{"$nulls":5},"cytosol;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},1,1,1,8,8,8,"27.33",0,"30.073",28739000,1,"0.466952","0.53586","-0.845066","-1.23832","tr|Q5TGM0|Q5TGM0_HUMAN;tr|A0A087WY55|A0A087WY55_HUMAN;sp|Q9NP79|VTA1_HUMAN","tr|Q5TGM0|Q5TGM0_HUMAN;tr|A0A087WY55|A0A087WY55_HUMAN;sp|Q9NP79|VTA1_HUMAN",2655,"Q5TGM0","Q5TGM0_HUMAN",null,null,"VTA1"]
["17.6562","17.2685","18.4737","18.1418",{"$nulls":3},"proteasome assembly;ubiquitin-dependent ERAD pathway","protein complex scaffold activity","centrosome;COPII-coated ER to Golgi transport vesicle;cytoplasmic vesicle;early endosome;endocytic vesicle;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;late endosome;membrane;multivesicular body;nucleus;proteasome complex",{"$nulls":3},8,8,8,"5.8","5.8","5.8","204.29",0,"46.287",233530000,21,"1.0953","0.306596","-0.845437","-3.3128","sp|Q5VYK3|ECM29_HUMAN;tr|J3KN16|J3KN16_HUMAN;tr|R4GMY1|R4GMY1_HUMAN;tr|F6XAQ5|F6XAQ5_HUMAN","sp|Q5VYK3|ECM29_HUMAN;tr|J3KN16|J3KN16_HUMAN",1848,"Q5VYK3","ECM29_HUMAN","Proteasome-associated protein ECM29 homolog","cm29","ECM29"]
["19.0714","18.9726","19.977","19.7624",{"$nulls":3},"cap-independent translational initiation;cell differentiation;circadian regulation of translation;entrainment of circadian clock by photoperiod;IRES-dependent translational initiation of linear mRNA;miRNA mediated inhibition of translation;mRNA processing;negative regulation of translation;negative regulation of translation in response to stress;negative regulation of translational initiation;positive regulation of muscle cell differentiation;regulation of alternative mRNA splicing, via spliceosome;regulation of nucleocytoplasmic transport;response to arsenic-containing substance;RNA processing;RNA splicing","cyclin binding;miRNA binding;mRNA 3'-UTR binding;mRNA binding;pre-mRNA intronic binding;pre-mRNA intronic pyrimidine-rich binding;RNA binding;zinc ion binding","cytoplasm;cytoplasmic stress granule;cytosol;nuclear speck;nucleolus;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"12.1","12.1","12.1","40.313",0,"34.061",136290000,18,"1.72443","0.3529","-0.847755","-7.17798","sp|Q9BWF3|RBM4_HUMAN;tr|E9PB51|E9PB51_HUMAN","sp|Q9BWF3|RBM4_HUMAN;tr|E9PB51|E9PB51_HUMAN",2485,"Q9BWF3","RBM4_HUMAN","RNA-binding protein 4",null,"RBM4"]
["19.0585","18.9581","20.3172","19.3976",{"$nulls":3},"mitochondrial ATP synthesis coupled electron transport;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;respiratory gaseous exchange;response to oxidative stress","electron transfer activity;NADH dehydrogenase (ubiquinone) activity","cytosol;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,1,1,1,"11.7","11.7","11.7","17.114",0,"13.807",61568000,9,"0.682373","0.377613","-0.84911","-1.83589","sp|Q9UI09|NDUAC_HUMAN","sp|Q9UI09|NDUAC_HUMAN",2843,"Q9UI09","NDUAC_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12",null,"NDUFA12"]
["18.9484","18.8924","20.1551","19.3866",{"$nulls":3},"amelogenesis;autophagy;cell adhesion;cell motility;cell-matrix adhesion;digestive tract development;extracellular matrix organization;hemidesmosome assembly;integrin-mediated signaling pathway;mesodermal cell differentiation;nail development;renal system development;response to wounding;skin development","G-protein coupled receptor binding;receptor activity","cell junction;cell leading edge;cell surface;extracellular exosome;hemidesmosome;integrin complex;nucleus;plasma membrane;receptor complex","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);PI3K-Akt signaling pathway;Regulation of actin cytoskeleton",null,null,24,24,24,"18.9","18.9","18.9","202.16",0,"76.89",811470000,81,"0.801385","0.328422","-0.850473","-2.2074","sp|P16144|ITB4_HUMAN;tr|J3QS11|J3QS11_HUMAN;tr|J3QQL2|J3QQL2_HUMAN;tr|J3QRK0|J3QRK0_HUMAN;tr|J3KSH9|J3KSH9_HUMAN","sp|P16144|ITB4_HUMAN",693,"P16144","ITB4_HUMAN","Integrin beta-4",null,"ITGB4"]
["16.2508","16.4456","17.1935","17.206",{"$nulls":3},"intra-Golgi vesicle-mediated transport;spermatogenesis","cadherin binding;transporter activity","cytosol;extrinsic component of Golgi membrane;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;Golgi transport complex;membrane;nucleolus;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"4.1","4.1","4.1","167.35",0,"6.1049",83203000,4,"1.89","0.396217","-0.851542","-8.72518","sp|Q08378|GOGA3_HUMAN","sp|Q08378|GOGA3_HUMAN",1472,"Q08378","GOGA3_HUMAN","Golgin subfamily A member 3",null,"GOLGA3"]
["18.7389","18.499","19.7083","19.2345",{"$nulls":9},4,4,4,"30.4","30.4","30.4","21.783",0,"17.418",46622000,10,"1.07127","0.303371","-0.852421","-3.21023","tr|I3L0W0|I3L0W0_HUMAN;sp|Q92667|AKAP1_HUMAN;tr|I3NI36|I3NI36_HUMAN","tr|I3L0W0|I3L0W0_HUMAN;sp|Q92667|AKAP1_HUMAN",2184,"I3L0W0","I3L0W0_HUMAN",null,null,"AKAP1"]
["20.2158","19.9","21.129","20.6927",{"$nulls":3},"cellular amino acid biosynthetic process;L-proline biosynthetic process;protein hexamerization;visual perception","identical protein binding;ornithine-oxo-acid transaminase activity;pyridoxal phosphate binding","mitochondrial matrix;mitochondrion;nucleoplasm","Arginine and proline metabolism;Metabolic pathways",null,null,7,7,7,"33.3","33.3","33.3","48.534",0,"89.575",422370000,39,"1.06096","0.303223","-0.852921","-3.16696","sp|P04181|OAT_HUMAN","sp|P04181|OAT_HUMAN",494,"P04181","OAT_HUMAN","Ornithine aminotransferase, mitochondrial",null,"OAT"]
["14.9224","15.0316","16.4426","15.2184",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;metaphase/anaphase transition of mitotic cell cycle;mitotic cell cycle;mitotic metaphase plate congression;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K11-linked ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of exit from mitosis;regulation of mitotic metaphase/anaphase transition;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;ubiquitin-dependent protein catabolic process","ubiquitin-protein transferase activity","anaphase-promoting complex;cytosol;intracellular;nucleoplasm","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis",null,null,1,1,1,"4.7","4.7","4.7","68.833","0.001406","2.3085",15963000,5,"0.523902","0.503328","-0.853511","-1.38895","sp|Q9UJX2|CDC23_HUMAN","sp|Q9UJX2|CDC23_HUMAN",2861,"Q9UJX2","CDC23_HUMAN","Cell division cycle protein 23 homolog",null,"CDC23"]
["15.7538","16.0415","16.7782","16.7249",{"$nulls":3},"axon guidance;nervous system development;signal transduction","hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;microtubule binding","cytosol;dendrite;neuronal cell body","Axon guidance",null,null,1,1,1,2,2,2,"61.421",0,"5.2526",25065000,8,"1.5511","0.329121","-0.853919","-5.83765","sp|Q9BPU6|DPYL5_HUMAN","sp|Q9BPU6|DPYL5_HUMAN",2405,"Q9BPU6","DPYL5_HUMAN","Dihydropyrimidinase-related protein 5","RP-5","DPYSL5"]
["18.6434","18.4212","19.4316","19.3412",{"$nulls":3},"transcription, DNA-templated","DNA binding;DNA-directed DNA polymerase activity","intracellular membrane-bounded organelle;nucleolus",{"$nulls":3},10,10,10,"10.4","10.4","10.4","140.13",0,"56.431",308130000,36,"1.71786","0.346405","-0.854095","-7.12235","tr|I3L1L3|I3L1L3_HUMAN;sp|Q9BQG0|MBB1A_HUMAN;tr|I3L2H8|I3L2H8_HUMAN","tr|I3L1L3|I3L1L3_HUMAN;sp|Q9BQG0|MBB1A_HUMAN",2420,"I3L1L3","I3L1L3_HUMAN",null,null,"MYBBP1A"]
["19.5094","19.3002","20.6884","19.8369",{"$nulls":3},"glutamine metabolic process","glutaminase activity",{"$nulls":4},1,1,1,"15.5","15.5","15.5","11.873",0,"8.4465",50979000,8,"0.722347","0.355103","-0.857881","-1.95674","tr|B8ZZC5|B8ZZC5_HUMAN;tr|B8ZZA8|B8ZZA8_HUMAN","tr|B8ZZC5|B8ZZC5_HUMAN;tr|B8ZZA8|B8ZZA8_HUMAN",3073,"B8ZZC5","B8ZZC5_HUMAN",null,null,"GLS"]
["18.7891","18.8864","19.9455","19.4468",{"$nulls":3},"male gonad development;nuclear-transcribed mRNA catabolic process, no-go decay;regulation of transcription, DNA-templated","DNA binding;RNA binding","CRD-mediated mRNA stability complex;cytosol;Golgi apparatus;mitochondrial inner membrane;plasma membrane",{"$nulls":3},12,12,12,"20.8","20.8","20.8","88.884",0,"36.757",438900000,32,"1.1104","0.310552","-0.858378","-3.37856","sp|O75534|CSDE1_HUMAN;tr|E9PLT0|E9PLT0_HUMAN;tr|E9PLD4|E9PLD4_HUMAN;tr|E9PNG3|E9PNG3_HUMAN","sp|O75534|CSDE1_HUMAN;tr|E9PLT0|E9PLT0_HUMAN",352,"O75534","CSDE1_HUMAN","Cold shock domain-containing protein E1",null,"CSDE1"]
["20.8228","20.6575","22.0506","21.1476",{"$nulls":3},"leukocyte migration;monocarboxylic acid transport;plasma membrane lactate transport;pyruvate metabolic process","lactate transmembrane transporter activity;monocarboxylic acid transmembrane transporter activity;RNA binding;symporter activity","integral component of membrane;integral component of plasma membrane;membrane;nuclear membrane;plasma membrane","Central carbon metabolism in cancer",null,null,4,4,4,"10.1","10.1","10.1","49.469",0,"33.389",481660000,20,"0.694216","0.372642","-0.858943","-1.87131","sp|O15427|MOT4_HUMAN;tr|J3QQV2|J3QQV2_HUMAN;tr|J3QSC3|J3QSC3_HUMAN;tr|J3QRP8|J3QRP8_HUMAN;tr|J3QLE3|J3QLE3_HUMAN;tr|J3KTM6|J3KTM6_HUMAN;tr|J3QRU2|J3QRU2_HUMAN;tr|J3KT83|J3KT83_HUMAN;tr|J3QRA0|J3QRA0_HUMAN;tr|J3QQS9|J3QQS9_HUMAN;tr|J3KTI8|J3KTI8_HUMAN","sp|O15427|MOT4_HUMAN;tr|J3QQV2|J3QQV2_HUMAN;tr|J3QSC3|J3QSC3_HUMAN",222,"O15427","MOT4_HUMAN","Monocarboxylate transporter 4","CT 4","SLC16A3"]
["16.331","15.8932","17.4125","16.5342",{"$nulls":3},"generation of catalytic spliceosome for second transesterification step;mRNA 3'-splice site recognition;mRNA splicing, via spliceosome;transcription-coupled nucleotide-excision repair","RNA binding","catalytic step 1 spliceosome;catalytic step 2 spliceosome;nucleoplasm;post-mRNA release spliceosomal complex;post-spliceosomal complex;Prp19 complex","Spliceosome",null,null,1,1,1,"4.9","4.9","4.9","32.992",0,"3.7524",13881000,6,"0.654955","0.391691","-0.861211","-1.75508","sp|Q9ULR0|ISY1_HUMAN","sp|Q9ULR0|ISY1_HUMAN",2895,"Q9ULR0","ISY1_HUMAN","Pre-mRNA-splicing factor ISY1 homolog",null,"ISY1"]
["17.5965","17.6078","19.0018","17.93",{"$nulls":3},"ATP-dependent chromatin remodeling",null,"SWI/SNF complex",{"$nulls":3},2,2,2,"17.8","17.8","17.8","18.257",0,"4.6336",35575000,8,"0.604957","0.430849","-0.863757","-1.61172","tr|H7C048|H7C048_HUMAN;tr|K7EMQ8|K7EMQ8_HUMAN;tr|B4DGM3|B4DGM3_HUMAN;sp|Q969G3|SMCE1_HUMAN;tr|J3QKS7|J3QKS7_HUMAN","tr|H7C048|H7C048_HUMAN;tr|K7EMQ8|K7EMQ8_HUMAN;tr|B4DGM3|B4DGM3_HUMAN;sp|Q969G3|SMCE1_HUMAN;tr|J3QKS7|J3QKS7_HUMAN",2218,"H7C048","H7C048_HUMAN",null,null,"SMARCE1"]
["18.0096",1,"19.7378",1,{"$nulls":3},"cell surface receptor signaling pathway",null,"extracellular exosome;integral component of plasma membrane;plasma membrane","p53 signaling pathway",null,null,1,1,1,"3.7","3.7","3.7","29.625",0,"7.0559",42442000,3,"0.0214684","0.975388","-0.864077","-0.0682882","sp|P27701|CD82_HUMAN","sp|P27701|CD82_HUMAN",826,"P27701","CD82_HUMAN","CD82 antigen",null,"CD82"]
["17.0678","16.9271","18.1464","17.577",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"7.2","7.2","7.2","27.423","0.00076394","2.9579",18227000,4,"1.00687","0.293899","-0.864298","-2.94707","tr|H0YNE5|H0YNE5_HUMAN;tr|H0YLG5|H0YLG5_HUMAN;sp|Q96TC7|RMD3_HUMAN","tr|H0YNE5|H0YNE5_HUMAN;tr|H0YLG5|H0YLG5_HUMAN;sp|Q96TC7|RMD3_HUMAN",2366,"H0YNE5","H0YNE5_HUMAN",null,null,"RMDN3"]
["18.4267","18.3261","19.5038","18.9783",{"$nulls":3},"protein targeting to ER;response to drug;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;SRP-dependent cotranslational protein targeting to membrane, translocation","7S RNA binding;drug binding;endoplasmic reticulum signal peptide binding;GDP binding;GTP binding;GTPase activity;ribonucleoprotein complex binding;RNA binding","cytoplasm;cytosol;nuclear speck;nucleus;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,5,5,5,"15.3","15.3","15.3","55.704",0,"66.689",141780000,20,"1.0765","0.304452","-0.864632","-3.23235","sp|P61011|SRP54_HUMAN;tr|G3V4F7|G3V4F7_HUMAN;tr|G3V480|G3V480_HUMAN;tr|G3V346|G3V346_HUMAN;tr|A0A0D9SFN7|A0A0D9SFN7_HUMAN;tr|G3V3L9|G3V3L9_HUMAN","sp|P61011|SRP54_HUMAN;tr|G3V4F7|G3V4F7_HUMAN",1251,"P61011","SRP54_HUMAN","Signal recognition particle 54 kDa protein","RP54","SRP54"]
["19.3427","19.3674","20.8323","19.6074",{"$nulls":3},"positive regulation of ruffle assembly;regulation of molecular function;regulation of Rho protein signal transduction;Rho protein signal transduction;sensory perception of sound","actin binding;cadherin binding","cytosol;extracellular exosome;plasma membrane;protein complex;ruffle membrane;stereocilium bundle;stereocilium tip;vesicle",{"$nulls":3},10,10,10,"24.9","24.9","24.9","80.62",0,"297.41",506000000,55,"0.532391","0.497232","-0.864817","-1.41179","sp|Q9H6S3|ES8L2_HUMAN;tr|A0A087WX39|A0A087WX39_HUMAN;tr|E9PLH1|E9PLH1_HUMAN","sp|Q9H6S3|ES8L2_HUMAN",2604,"Q9H6S3","ES8L2_HUMAN","Epidermal growth factor receptor kinase substrate 8-like protein 2","PS8-like protein 2","EPS8L2"]
["20.539","20.4725","21.6884","21.0588",{"$nulls":3},"developmental process;protein folding","unfolded protein binding","condensed chromosome kinetochore;cytoplasm;cytosol;extracellular exosome;intracellular;microtubule cytoskeleton;microtubule organizing center;spindle pole",{"$nulls":3},4,4,4,35,35,35,"17.676",0,"18.013",138760000,28,"0.953625","0.297737","-0.86789","-2.74165","sp|Q8WVJ2|NUDC2_HUMAN;tr|E5RFP0|E5RFP0_HUMAN","sp|Q8WVJ2|NUDC2_HUMAN;tr|E5RFP0|E5RFP0_HUMAN",2144,"Q8WVJ2","NUDC2_HUMAN","NudC domain-containing protein 2",null,"NUDCD2"]
["14.963","14.7124","15.6251","15.7885",{"$nulls":3},"cell division;meiotic chromosome segregation;mitotic sister chromatid cohesion;negative regulation of chromatin binding;negative regulation of DNA replication;negative regulation of sister chromatid cohesion;positive regulation of fibroblast proliferation;protein localization to chromatin;regulation of chromosome condensation;regulation of cohesin loading;response to toxic substance;sister chromatid cohesion;viral process",null,"chromatin;chromosome;chromosome, centromeric region;cohesin complex;cytoplasm;cytosol;nucleoplasm;nucleus;synaptonemal complex",{"$nulls":3},2,2,2,"2.6","2.6","2.6","132.94",0,"5.1326",27376000,6,"1.54712","0.321607","-0.869086","-5.80983","sp|Q7Z5K2|WAPL_HUMAN","sp|Q7Z5K2|WAPL_HUMAN",1959,"Q7Z5K2","WAPL_HUMAN","Wings apart-like protein homolog",null,"WAPL"]
["20.4821","21.8137","22.1199","21.9146",{"$nulls":3},"adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;calcium-mediated signaling;cyclic nucleotide metabolic process;cyclic-nucleotide-mediated signaling;diadenosine hexaphosphate catabolic process;diadenosine pentaphosphate catabolic process;diphosphoinositol polyphosphate metabolic process;inositol phosphate metabolic process;intracellular signal transduction;intracellular transport;regulation of RNA export from nucleus","bis(5'-adenosyl)-hexaphosphatase activity;bis(5'-adenosyl)-pentaphosphatase activity;diphosphoinositol-polyphosphate diphosphatase activity;endopolyphosphatase activity;inositol bisdiphosphate tetrakisphosphate diphosphatase activity;inositol diphosphate pentakisphosphate diphosphatase activity;inositol diphosphate tetrakisphosphate diphosphatase activity;inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity;inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity;inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity;inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity;m7G(5')pppN diphosphatase activity;metal ion binding;snoRNA binding","cytoplasm;cytosol;intracellular;nucleus",{"$nulls":3},3,3,3,"26.1","26.1","26.1","20.306",0,"9.4826",222390000,20,"0.486838","0.523394","-0.869343","-1.29044","sp|Q9NZJ9|NUDT4_HUMAN;tr|F8VRL4|F8VRL4_HUMAN;tr|F8VRR0|F8VRR0_HUMAN;tr|A0A0C4DGJ4|A0A0C4DGJ4_HUMAN;sp|Q96G61|NUD11_HUMAN;sp|Q8NFP7|NUD10_HUMAN","sp|Q9NZJ9|NUDT4_HUMAN",2758,"Q9NZJ9","NUDT4_HUMAN","Diphosphoinositol polyphosphate phosphohydrolase 2","IPP-2","NUDT4"]
["15.936","15.7574","17.0112","16.4219",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;activation-induced cell death of T cells;cell aging;mitochondrial DNA replication;mitochondrion organization;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interferon-gamma-mediated signaling pathway;negative regulation of NF-kappaB transcription factor activity;negative regulation of programmed cell death;negative regulation of protein kinase activity;negative regulation of transcription from RNA polymerase II promoter;neuromuscular junction development;positive regulation of apoptotic process;positive regulation of protein ubiquitination;positive regulation of T cell proliferation;protein folding;protein stabilization;response to heat;response to interferon-gamma;skeletal muscle acetylcholine-gated channel clustering;small GTPase mediated signal transduction;T cell differentiation in thymus","ATP binding;GTPase regulator activity;Hsp70 protein binding;interferon-gamma receptor binding;metal ion binding;NF-kappaB binding;protein kinase binding;transcription factor binding;unfolded protein binding","cell junction;cytoplasm;cytosol;extrinsic component of plasma membrane;intracellular membrane-bounded organelle;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;neuromuscular junction;nucleus;postsynaptic membrane","Viral carcinogenesis",null,null,1,1,1,"3.3","3.3","3.3","52.488","0.0010981","2.6039",16921000,1,"0.975679","0.296178","-0.869847","-2.82547","sp|Q96EY1|DNJA3_HUMAN","sp|Q96EY1|DNJA3_HUMAN",2265,"Q96EY1","DNJA3_HUMAN","DnaJ homolog subfamily A member 3, mitochondrial",null,"DNAJA3"]
["17.0641","18.2994","17.9227","19.1808",{"$nulls":3},"negative regulation of transcription, DNA-templated;positive regulation of cell proliferation;protein homooligomerization;transcription, DNA-templated",null,"cell junction;cytoplasm;intracellular membrane-bounded organelle;nuclear body;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"4.4","4.4","4.4","57.258",0,"8.328",55655000,9,"0.368808","0.660109","-0.869967","-0.986831","sp|Q96RE7|NACC1_HUMAN","sp|Q96RE7|NACC1_HUMAN",2342,"Q96RE7","NACC1_HUMAN","Nucleus accumbens-associated protein 1","AC-1","NACC1"]
["20.2614","20.1144","21.1832","20.9356",{"$nulls":3},"animal organ morphogenesis;cytochrome c-heme linkage;oxidation-reduction process","holocytochrome-c synthase activity;metal ion binding","mitochondrial inner membrane;mitochondrion","Porphyrin and chlorophyll metabolism",null,null,7,7,7,"34.3","34.3","34.3","30.601",0,"30.603",243040000,38,"1.58124","0.334588","-0.871487","-6.05261","sp|P53701|CCHL_HUMAN","sp|P53701|CCHL_HUMAN",1183,"P53701","CCHL_HUMAN","Cytochrome c-type heme lyase","CHL","HCCS"]
["19.6517","19.5528","20.4172","20.5315",{"$nulls":3},"hydrogen ion transmembrane transport;mitochondrial electron transport, cytochrome c to oxygen;mitochondrial electron transport, NADH to ubiquinone","NADH dehydrogenase (ubiquinone) activity;protein complex binding","extracellular exosome;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrial respiratory chain complex IV;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,1,1,1,"9.9","9.9","9.9","9.3697","0.0053583","1.8874",47604000,2,"2.12937","0.400155","-0.87208","-11.5413","sp|O00483|NDUA4_HUMAN","sp|O00483|NDUA4_HUMAN",145,"O00483","NDUA4_HUMAN","Cytochrome c oxidase subunit NDUFA4",null,"NDUFA4"]
["19.8771","19.8887","21.1779","20.3398",{"$nulls":3},"SRP-dependent cotranslational protein targeting to membrane",null,"integral component of membrane;intracellular",{"$nulls":3},1,1,1,8,8,8,"20.161","0.00039573","3.2975",69716000,7,"0.76507","0.337472","-0.875952","-2.0902","tr|C9JA28|C9JA28_HUMAN;sp|Q9UNL2|SSRG_HUMAN","tr|C9JA28|C9JA28_HUMAN;sp|Q9UNL2|SSRG_HUMAN",2913,"C9JA28","C9JA28_HUMAN",null,null,"SSR3"]
["14.6144","14.5018","15.7706","15.0975",{"$nulls":3},"platelet degranulation","endonuclease activity;metal ion binding;nucleic acid binding","cytosol;extracellular exosome;extracellular region;membrane",{"$nulls":3},1,1,1,"2.8","2.8","2.8","55.016",0,"3.5913",12258000,3,"0.906168","0.295255","-0.875959","-2.5671","sp|O94919|ENDD1_HUMAN","sp|O94919|ENDD1_HUMAN",401,"O94919","ENDD1_HUMAN","Endonuclease domain-containing 1 protein",null,"ENDOD1"]
["19.6118","19.7067","20.6342","20.4362",{"$nulls":4},"ubiquitin protein ligase activity","nucleus",{"$nulls":3},3,3,3,"20.3","20.3","20.3","26.804",0,"120.26",158040000,18,"1.81395","0.375832","-0.875985","-7.97866","tr|M0R3B2|M0R3B2_HUMAN;sp|Q9Y314|NOSIP_HUMAN;tr|A0A075B797|A0A075B797_HUMAN;tr|A0A075B6F9|A0A075B6F9_HUMAN;tr|M0R1T7|M0R1T7_HUMAN;tr|M0QX85|M0QX85_HUMAN;tr|M0R1K2|M0R1K2_HUMAN","tr|M0R3B2|M0R3B2_HUMAN;sp|Q9Y314|NOSIP_HUMAN;tr|A0A075B797|A0A075B797_HUMAN;tr|A0A075B6F9|A0A075B6F9_HUMAN",2968,"M0R3B2","M0R3B2_HUMAN",null,null,"NOSIP"]
["18.9743","18.8108","20.1363","19.4024",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},5,5,5,14,14,14,"54.945",0,"17.598",227010000,28,"0.838831","0.313029","-0.876816","-2.33212","tr|A0A087X1A5|A0A087X1A5_HUMAN;sp|O95793|STAU1_HUMAN;tr|Q5JW30|Q5JW30_HUMAN;tr|Q5JW28|Q5JW28_HUMAN;tr|F6UDC6|F6UDC6_HUMAN","tr|A0A087X1A5|A0A087X1A5_HUMAN;sp|O95793|STAU1_HUMAN;tr|Q5JW30|Q5JW30_HUMAN",450,"A0A087X1A5","A0A087X1A5_HUMAN",null,null,"STAU1"]
["21.1932","20.9622","22.4097","21.5038",{"$nulls":3},"response to stress","ATPase activator activity;cadherin binding;chaperone binding","cytosol;endoplasmic reticulum;extracellular exosome",{"$nulls":3},11,11,11,"42.3","42.3","42.3","38.274",0,"38.278",687780000,47,"0.697246","0.368596","-0.879055","-1.88042","sp|O95433|AHSA1_HUMAN;tr|G3V438|G3V438_HUMAN;tr|H0YJG7|H0YJG7_HUMAN;tr|G3V3W9|G3V3W9_HUMAN;tr|H0YJU2|H0YJU2_HUMAN;tr|H0YJ63|H0YJ63_HUMAN","sp|O95433|AHSA1_HUMAN;tr|G3V438|G3V438_HUMAN",435,"O95433","AHSA1_HUMAN","Activator of 90 kDa heat shock protein ATPase homolog 1","HA1","AHSA1"]
["17.6034","18.0063","18.8843","18.4846",{"$nulls":3},"actin filament organization;cell communication by chemical coupling;cell communication by electrical coupling;maintenance of protein location in cell;neural precursor cell proliferation;regulation of dendrite development;regulation of neuronal synaptic plasticity","actin binding;cadherin binding;profilin binding","actin cytoskeleton;actomyosin;cortical cytoskeleton;cytoplasm;dendrite;gap junction;growth cone;plasma membrane",{"$nulls":3},3,3,3,"10.8","10.8","10.8","71.428",0,"32.027",61867000,11,"1.04468","0.301898","-0.879627","-3.09954","sp|Q16643|DREB_HUMAN;tr|D6R9Q9|D6R9Q9_HUMAN;tr|D6R9W4|D6R9W4_HUMAN","sp|Q16643|DREB_HUMAN;tr|D6R9Q9|D6R9Q9_HUMAN",1747,"Q16643","DREB_HUMAN","Drebrin",null,"DBN1"]
["20.3834","20.5628","21.5861","21.1269",{"$nulls":3},"calcium ion homeostasis;cellular protein metabolic process;endoplasmic reticulum calcium ion homeostasis;ER overload response;glucose homeostasis;IRE1-mediated unfolded protein response;kidney development;negative regulation of ATF6-mediated unfolded protein response;negative regulation of DNA binding transcription factor activity;negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;negative regulation of neuron apoptotic process;negative regulation of programmed cell death;negative regulation of transcription from RNA polymerase II promoter;negative regulation of type B pancreatic cell apoptotic process;nervous system process;olfactory behavior;pancreas development;positive regulation of adenylate cyclase activity;positive regulation of calcium ion transport;positive regulation of growth;positive regulation of protein metabolic process;positive regulation of protein ubiquitination;post-translational protein modification;protein maturation by protein folding;protein stabilization;renal water homeostasis;response to endoplasmic reticulum stress;sensory perception of sound;ubiquitin-dependent ERAD pathway;visual perception","activating transcription factor binding;ATPase binding;calcium-dependent protein binding;calmodulin binding;ubiquitin protein ligase binding","dendrite;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;proteasome complex","Protein processing in endoplasmic reticulum",null,null,6,6,6,"10.9","10.9","10.9","100.29",0,"91.471",635520000,52,"1.15606","0.312759","-0.883332","-3.58356","sp|O76024|WFS1_HUMAN;tr|H0Y9G5|H0Y9G5_HUMAN","sp|O76024|WFS1_HUMAN;tr|H0Y9G5|H0Y9G5_HUMAN",385,"O76024","WFS1_HUMAN","Wolframin",null,"WFS1"]
["18.3116","18.4784","19.4609","19.0961",{"$nulls":3},"actin filament polymerization","actin binding;Rho GTPase binding",{"$nulls":4},10,10,10,"10.1","10.1","10.1","141.36",0,"126.45",346560000,53,"1.31994","0.33261","-0.883427","-4.40481","tr|A0A0G2JH68|A0A0G2JH68_HUMAN;sp|O60610|DIAP1_HUMAN;tr|H9KV28|H9KV28_HUMAN;tr|B4E2I7|B4E2I7_HUMAN","tr|A0A0G2JH68|A0A0G2JH68_HUMAN;sp|O60610|DIAP1_HUMAN;tr|H9KV28|H9KV28_HUMAN",296,"A0A0G2JH68","A0A0G2JH68_HUMAN",null,null,"DIAPH1"]
["18.4771","18.4178","19.6203","19.0422",{"$nulls":9},1,1,1,"7.3","7.3","7.3","18.573","0.0010937","2.546",59385000,3,"1.03052","0.298884","-0.883837","-3.04177","tr|H7C5F2|H7C5F2_HUMAN;tr|H7C5H3|H7C5H3_HUMAN;tr|G5E9W7|G5E9W7_HUMAN;tr|G5E9V5|G5E9V5_HUMAN;sp|P82650|RT22_HUMAN","tr|H7C5F2|H7C5F2_HUMAN;tr|H7C5H3|H7C5H3_HUMAN;tr|G5E9W7|G5E9W7_HUMAN;tr|G5E9V5|G5E9V5_HUMAN;sp|P82650|RT22_HUMAN",1377,"H7C5F2","H7C5F2_HUMAN",null,null,"MRPS22"]
["19.7124","19.6373","20.94","20.1795",{"$nulls":3},"tRNA aminoacylation for protein translation;valyl-tRNA aminoacylation","aminoacyl-tRNA editing activity;ATP binding;valine-tRNA ligase activity","cytosol;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,7,7,7,"10.2","10.2","10.2","140.47",0,"100.98",735040000,42,"0.834045","0.313577","-0.884913","-2.31595","sp|P26640|SYVC_HUMAN;tr|A2ABF4|A2ABF4_HUMAN;tr|A0A0G2JJT9|A0A0G2JJT9_HUMAN;tr|H0Y426|H0Y426_HUMAN","sp|P26640|SYVC_HUMAN",816,"P26640","SYVC_HUMAN","Valine--tRNA ligase",null,"VARS"]
["17.4527","17.5009","18.3467","18.3777",{"$nulls":5},"nucleoplasm",{"$nulls":3},1,1,1,"3.4","3.4","3.4","53.878",0,"29.929",51915000,9,"2.98101","0.525667","-0.885355","-30.9147","tr|A0A0A0MRT2|A0A0A0MRT2_HUMAN;sp|Q9BTA9|WAC_HUMAN","tr|A0A0A0MRT2|A0A0A0MRT2_HUMAN;sp|Q9BTA9|WAC_HUMAN",2442,"A0A0A0MRT2","A0A0A0MRT2_HUMAN",null,null,"WAC"]
["15.9769","15.3901","17.0711","16.0685",{"$nulls":9},1,1,1,"8.8","8.8","8.8","23.074","0.001119","2.7741",10369000,2,"0.574189","0.463648","-0.886256","-1.52586","tr|X6R5E5|X6R5E5_HUMAN;sp|Q8NBM4|UBAC2_HUMAN","tr|X6R5E5|X6R5E5_HUMAN;sp|Q8NBM4|UBAC2_HUMAN",2073,"X6R5E5","X6R5E5_HUMAN",null,null,"UBAC2"]
["25.1044","25.3027","26.0009","26.1793",{"$nulls":3},"cytoplasmic translation;embryo implantation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;heparin binding;RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;membrane","Ribosome",null,null,2,2,2,"14.5","14.5","14.5","17.752",0,"10.652",2110600000,18,"1.65964","0.336223","-0.886521","-6.6465","sp|P47914|RL29_HUMAN","sp|P47914|RL29_HUMAN",1048,"P47914","RL29_HUMAN","60S ribosomal protein L29",null,"RPL29"]
["20.256","20.3667","21.79","20.6067",{"$nulls":3},"multicellular organism development;platelet degranulation","cytokine activity","extracellular exosome;extracellular region;platelet dense granule lumen",{"$nulls":3},4,4,4,"24.2","24.2","24.2","24.68",0,"31.514",249800000,20,"0.562115","0.4715","-0.886977","-1.49262","sp|Q92520|FAM3C_HUMAN;tr|C9JP35|C9JP35_HUMAN;tr|C9JMN4|C9JMN4_HUMAN","sp|Q92520|FAM3C_HUMAN",2166,"Q92520","FAM3C_HUMAN","Protein FAM3C",null,"FAM3C"]
["19.5956","20.1297","20.9362","20.565",{"$nulls":3},"brain development;glutaminyl-tRNA aminoacylation;negative regulation of apoptotic signaling pathway;negative regulation of protein kinase activity;negative regulation of stress-activated MAPK cascade;negative regulation of transcription, DNA-templated;tRNA aminoacylation for protein translation","ATP binding;glutamine-tRNA ligase activity;protein kinase binding;protein kinase inhibitor activity","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;mitochondrial matrix;protein complex","Aminoacyl-tRNA biosynthesis;Metabolic pathways",null,null,13,12,12,"19.6","18.6","18.6","87.798",0,"58.79",631600000,39,"0.95069","0.29668","-0.887971","-2.73063","sp|P47897|SYQ_HUMAN;tr|C9J165|C9J165_HUMAN;tr|H7C0R3|H7C0R3_HUMAN;tr|F2Z2V6|F2Z2V6_HUMAN","sp|P47897|SYQ_HUMAN",1047,"P47897","SYQ_HUMAN","Glutamine--tRNA ligase",null,"QARS"]
["18.6712","18.94","19.9451","19.443",{"$nulls":3},"DNA damage response, detection of DNA damage;DNA replication;DNA strand elongation involved in DNA replication;DNA synthesis involved in DNA repair;error-free translesion synthesis;error-prone translesion synthesis;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of DNA-directed DNA polymerase activity;regulation of signal transduction by p53 class mediator;response to organophosphorus;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","DNA clamp loader activity","Ctf18 RFC-like complex;DNA replication factor C complex;nucleoplasm;nucleus","DNA replication;Mismatch repair;Nucleotide excision repair",null,null,2,2,2,"7.9","7.9","7.9","40.556",0,"15.783",134100000,9,"1.04969","0.305492","-0.888442","-3.12019","sp|P40938|RFC3_HUMAN;tr|A0A087X270|A0A087X270_HUMAN","sp|P40938|RFC3_HUMAN;tr|A0A087X270|A0A087X270_HUMAN",977,"P40938","RFC3_HUMAN","Replication factor C subunit 3",null,"RFC3"]
["17.9761","17.9073","18.7001","18.9602",{"$nulls":4},"phosphoric ester hydrolase activity","integral component of membrane",{"$nulls":3},4,4,4,"8.9","8.9","8.9","55.571",0,"10.432",80248000,11,"1.65425","0.332508","-0.888474","-6.60404","tr|E9PGZ4|E9PGZ4_HUMAN;sp|Q9NTJ5|SAC1_HUMAN;tr|C9JV50|C9JV50_HUMAN;tr|F8WDN7|F8WDN7_HUMAN;tr|C9J3E3|C9J3E3_HUMAN","tr|E9PGZ4|E9PGZ4_HUMAN;sp|Q9NTJ5|SAC1_HUMAN;tr|C9JV50|C9JV50_HUMAN;tr|F8WDN7|F8WDN7_HUMAN",2699,"E9PGZ4","E9PGZ4_HUMAN",null,null,"SACM1L"]
["12.8225","12.7181","13.9867","13.3309",{"$nulls":3},"activation of protein kinase B activity;anoikis;brain development;cardiac muscle cell development;cardiac muscle contraction;cell aging;cell cycle arrest;cellular response to amino acid starvation;cellular response to amino acid stimulus;cellular response to hypoxia;cellular response to leucine;cellular response to leucine starvation;cellular response to nutrient levels;cellular response to starvation;'de novo' pyrimidine nucleobase biosynthetic process;DNA repair;energy reserve metabolic process;germ cell development;growth;heart morphogenesis;heart valve morphogenesis;long-term memory;maternal process involved in female pregnancy;mRNA stabilization;multicellular organism growth;negative regulation of autophagy;negative regulation of cell size;negative regulation of cholangiocyte apoptotic process;negative regulation of iodide transmembrane transport;negative regulation of macroautophagy;negative regulation of muscle atrophy;negative regulation of NFAT protein import into nucleus;negative regulation of protein phosphorylation;negative regulation of protein ubiquitination;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;phosphorylation;positive regulation of actin filament polymerization;positive regulation of cell growth involved in cardiac muscle cell development;positive regulation of cholangiocyte proliferation;positive regulation of dendritic spine development;positive regulation of eating behavior;positive regulation of endothelial cell proliferation;positive regulation of epithelial to mesenchymal transition;positive regulation of gene expression;positive regulation of glial cell proliferation;positive regulation of granulosa cell proliferation;positive regulation of keratinocyte migration;positive regulation of lamellipodium assembly;positive regulation of lipid biosynthetic process;positive regulation of myotube differentiation;positive regulation of neuron death;positive regulation of neuron maturation;positive regulation of nitric oxide biosynthetic process;positive regulation of oligodendrocyte differentiation;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of protein kinase B signaling;positive regulation of protein phosphorylation;positive regulation of sensory perception of pain;positive regulation of skeletal muscle hypertrophy;positive regulation of smooth muscle cell proliferation;positive regulation of stress fiber assembly;positive regulation of transcription from RNA polymerase III promoter;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;positive regulation of translation;positive regulation of wound healing, spreading of epidermal cells;post-embryonic development;protein autophosphorylation;protein catabolic process;protein phosphorylation;regulation of actin cytoskeleton organization;regulation of brown fat cell differentiation;regulation of carbohydrate utilization;regulation of cell growth;regulation of cell size;regulation of cellular response to heat;regulation of fatty acid beta-oxidation;regulation of glycogen biosynthetic process;regulation of GTPase activity;regulation of macroautophagy;regulation of membrane permeability;regulation of myelination;regulation of osteoclast differentiation;regulation of response to food;response to amino acid;response to cocaine;response to insulin;response to morphine;response to nutrient;ruffle organization;signal transduction;social behavior;spinal cord development;TOR signaling;TORC1 signaling;visual learning;voluntary musculoskeletal movement;wound healing","ATP binding;identical protein binding;kinase activity;phosphoprotein binding;protein domain specific binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;ribosome binding;RNA polymerase III type 1 promoter DNA binding;RNA polymerase III type 2 promoter DNA binding;RNA polymerase III type 3 promoter DNA binding;TFIIIC-class transcription factor binding","cytoplasm;cytosol;dendrite;endomembrane system;endoplasmic reticulum membrane;Golgi membrane;lysosomal membrane;lysosome;membrane;mitochondrial outer membrane;neuronal cell body;nucleoplasm;nucleus;phosphatidylinositol 3-kinase complex;PML body;TORC1 complex;TORC2 complex","Acute myeloid leukemia;Adipocytokine signaling pathway;AMPK signaling pathway;Apelin signaling pathway;Autophagy - animal;Autophagy - other;Breast cancer;Cellular senescence;Central carbon metabolism in cancer;Choline metabolism in cancer;Colorectal cancer;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;ErbB signaling pathway;Gastric cancer;Glioma;Hepatocellular carcinoma;Herpes simplex virus 1 infection;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Insulin resistance;Insulin signaling pathway;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Longevity regulating pathway;Longevity regulating pathway - multiple species;MicroRNAs in cancer;mTOR signaling pathway;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prostate cancer;Proteoglycans in cancer;Th17 cell differentiation;Thermogenesis;Thyroid hormone signaling pathway;Type II diabetes mellitus",null,null,1,1,1,"0.7","0.7","0.7","288.89","0.0011103","2.7247",13054000,3,"0.935989","0.298257","-0.888484","-2.67588","sp|P42345|MTOR_HUMAN","sp|P42345|MTOR_HUMAN",994,"P42345","MTOR_HUMAN","Serine/threonine-protein kinase mTOR",null,"MTOR"]
["21.1163","20.9164","20.2026","23.6087",{"$nulls":3},"intracellular protein transport;organelle assembly;organelle localization;positive regulation of receptor localization to synapse;positive regulation of T cell mediated cytotoxicity;regulation of protein localization to plasma membrane;vesicle docking;vesicle fusion","chloride channel inhibitor activity;SNAP receptor activity;SNARE binding;syntaxin binding","azurophil granule;early endosome;early endosome membrane;endocytic vesicle;endosome;extracellular exosome;immunological synapse;integral component of membrane;late endosome;lysosomal membrane;lysosome;perinuclear region of cytoplasm;plasma membrane;recycling endosome;SNARE complex;tertiary granule;vesicle","Phagosome;SNARE interactions in vesicular transport",null,null,7,7,7,"33.3","33.3","33.3","29.815",0,"17.837",273700000,20,"0.184334","0.833677","-0.889334","-0.521303","sp|O15400|STX7_HUMAN","sp|O15400|STX7_HUMAN",221,"O15400","STX7_HUMAN","Syntaxin-7",null,"STX7"]
["17.894","18.1299","18.8141","18.9896",{"$nulls":3},"ATP-dependent chromatin remodeling",null,"nucleoplasm;SWI/SNF complex",{"$nulls":3},1,1,1,"4.4","4.4","4.4","52.238",0,"124.43",104850000,9,"1.58128","0.336236","-0.889883","-6.05294","tr|J3KMX2|J3KMX2_HUMAN;tr|B9EGA3|B9EGA3_HUMAN;sp|Q92925|SMRD2_HUMAN","tr|J3KMX2|J3KMX2_HUMAN;tr|B9EGA3|B9EGA3_HUMAN;sp|Q92925|SMRD2_HUMAN",2205,"J3KMX2","J3KMX2_HUMAN",null,null,"SMARCD2"]
["15.9913","16.4205","17.0601","17.132",{"$nulls":3},"cellular response to lipopolysaccharide;cellular response to tumor necrosis factor;mRNA processing;mRNA splicing, via spliceosome;RNA splicing;RNA splicing, via transesterification reactions;spliceosomal tri-snRNP complex assembly","K63-linked polyubiquitin modification-dependent protein binding;pre-mRNA intronic binding;RNA binding;second spliceosomal transesterification activity;U1 snRNA binding;U2 snRNA binding;U5 snRNA binding;U6 snRNA binding","catalytic step 2 spliceosome;membrane;nuclear speck;nucleoplasm;nucleus;U4/U6 x U5 tri-snRNP complex;U5 snRNP","Spliceosome",null,null,9,9,9,"5.9","5.9","5.9","273.6",0,"31.946",147850000,33,"1.26056","0.325104","-0.890132","-4.09078","sp|Q6P2Q9|PRP8_HUMAN;tr|I3L0J9|I3L0J9_HUMAN;tr|I3L3Z8|I3L3Z8_HUMAN","sp|Q6P2Q9|PRP8_HUMAN",1887,"Q6P2Q9","PRP8_HUMAN","Pre-mRNA-processing-splicing factor 8",null,"PRPF8"]
["17.1426","17.3234","18.4993","17.7483",{"$nulls":3},"COPII vesicle coating;regulation of phosphoprotein phosphatase activity","protein phosphatase binding","cytosol;Golgi membrane",{"$nulls":3},5,5,5,"13.6","13.6","13.6","96.723",0,"11.201",58629000,14,"0.83114","0.314149","-0.89077","-2.30617","sp|Q9UPN7|PP6R1_HUMAN","sp|Q9UPN7|PP6R1_HUMAN",2921,"Q9UPN7","PP6R1_HUMAN","Serine/threonine-protein phosphatase 6 regulatory subunit 1",null,"PPP6R1"]
["18.1144","18.0728","19.0074","18.9614",{"$nulls":3},"retrograde protein transport, ER to cytosol;ubiquitin-dependent ERAD pathway","ubiquitin binding;ubiquitin-protein transferase activator activity","extracellular exosome;Hrd1p ubiquitin ligase ERAD-L complex;integral component of endoplasmic reticulum membrane;membrane",{"$nulls":3},3,3,3,"10.1","10.1","10.1","53.028",0,"17.712",84199000,11,"2.91746","0.516615","-0.89081","-28.7299","sp|Q9Y679|AUP1_HUMAN","sp|Q9Y679|AUP1_HUMAN",3041,"Q9Y679","AUP1_HUMAN","Ancient ubiquitous protein 1",null,"AUP1"]
["21.6011","21.303","22.5722","22.1172",{"$nulls":3},"defense response to virus;immune response;negative regulation of viral entry into host cell;negative regulation of viral genome replication;negative regulation of viral transcription;response to interferon-alpha;response to interferon-beta;response to interferon-gamma;response to virus;type I interferon signaling pathway",null,"extracellular exosome;integral component of membrane;late endosome membrane;lysosomal membrane;plasma membrane",{"$nulls":3},2,2,2,"30.1","30.1","30.1","14.632",0,"11.7",290940000,9,"1.08813","0.30879","-0.892658","-3.28194","sp|Q01628|IFM3_HUMAN;tr|H7BYV1|H7BYV1_HUMAN;tr|E9PS44|E9PS44_HUMAN;tr|E9PQN9|E9PQN9_HUMAN;sp|P13164|IFM1_HUMAN;sp|Q01629|IFM2_HUMAN;sp|C9JQL5|DSA2D_HUMAN","sp|Q01628|IFM3_HUMAN;tr|H7BYV1|H7BYV1_HUMAN;tr|E9PS44|E9PS44_HUMAN;tr|E9PQN9|E9PQN9_HUMAN;sp|P13164|IFM1_HUMAN;sp|Q01629|IFM2_HUMAN;sp|C9JQL5|DSA2D_HUMAN",1417,"Q01628","IFM3_HUMAN","Interferon-induced transmembrane protein 3",null,"IFITM3"]
["18.3288","18.1467","19.6384","18.6238",{"$nulls":9},3,3,3,"15.6","15.6","15.6","35.421",0,"15.71",70672000,15,"0.647459","0.399092","-0.893316","-1.73327","tr|A0A0D9SFS2|A0A0D9SFS2_HUMAN;sp|Q15654|TRIP6_HUMAN","tr|A0A0D9SFS2|A0A0D9SFS2_HUMAN;sp|Q15654|TRIP6_HUMAN",1715,"A0A0D9SFS2"]
["18.9778","18.6153","19.4824","19.8984",{"$nulls":9},2,2,2,"23.3","23.3","23.3","14.726",0,"6.488",58717000,15,"1.07823","0.30395","-0.893864","-3.23968","tr|H0YJB9|H0YJB9_HUMAN;tr|G3V4C6|G3V4C6_HUMAN;sp|Q9Y224|CN166_HUMAN","tr|H0YJB9|H0YJB9_HUMAN;tr|G3V4C6|G3V4C6_HUMAN;sp|Q9Y224|CN166_HUMAN",2935,"H0YJB9","H0YJB9_HUMAN",null,null,"RTRAF"]
["16.4642","16.8894","17.672","17.4702",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;cellular response to DNA damage stimulus;DNA repair;Fc-epsilon receptor signaling pathway;MAPK cascade;multicellular organism development;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasomal ubiquitin-independent protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;spermatogenesis, exchange of chromosomal proteins;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","lysine-acetylated histone binding;peptidase activator activity;proteasome binding","cytosol;nuclear speck;nucleoplasm;nucleus;proteasome core complex;spermatoproteasome complex","Proteasome",null,null,4,4,4,"2.7","2.7","2.7","211.33",0,"8.0665",141580000,12,"1.20204","0.327869","-0.894294","-3.79996","sp|Q14997|PSME4_HUMAN;tr|F8WBH5|F8WBH5_HUMAN","sp|Q14997|PSME4_HUMAN;tr|F8WBH5|F8WBH5_HUMAN",1652,"Q14997","PSME4_HUMAN","Proteasome activator complex subunit 4",null,"PSME4"]
["18.7492","20.641","20.9449","20.235",{"$nulls":3},"intracellular transport of virus;modulation by virus of host process;NLS-bearing protein import into nucleus;response to hydrogen peroxide","nuclear localization sequence binding;protein transporter activity","cytosol;extracellular exosome;host cell;nuclear pore;nucleoplasm",{"$nulls":3},5,5,3,"17.3","17.3","11.5","57.886",0,"25.825",176430000,20,"0.32863","0.703891","-0.894837","-0.885713","sp|O00629|IMA3_HUMAN;tr|H7C4F6|H7C4F6_HUMAN","sp|O00629|IMA3_HUMAN",154,"O00629","IMA3_HUMAN","Importin subunit alpha-3",null,"KPNA4"]
["18.7012","18.4989","20.402","18.5921",{"$nulls":4},"peptidase activity",{"$nulls":4},1,1,1,"18.7","18.7","18.7","9.658",0,"29.49",34145000,2,"0.368132","0.660052","-0.897001","-0.985123","tr|H0YJN9|H0YJN9_HUMAN;tr|G3V2T4|G3V2T4_HUMAN;tr|G3V4E4|G3V4E4_HUMAN;sp|Q99538|LGMN_HUMAN","tr|H0YJN9|H0YJN9_HUMAN;tr|G3V2T4|G3V2T4_HUMAN;tr|G3V4E4|G3V4E4_HUMAN;sp|Q99538|LGMN_HUMAN",2380,"H0YJN9","H0YJN9_HUMAN",null,null,"LGMN"]
["19.5927","19.0357","20.9755","19.448",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"21.8","21.8","21.8","17.963",0,"75.887",53464000,10,"0.414985","0.5997","-0.897583","-1.10413","tr|E9PJK1|E9PJK1_HUMAN;tr|E9PRJ8|E9PRJ8_HUMAN;tr|H0YDL9|H0YDL9_HUMAN;tr|H0YDJ9|H0YDJ9_HUMAN;sp|P60033|CD81_HUMAN;tr|E9PIF1|E9PIF1_HUMAN;tr|A6NMH8|A6NMH8_HUMAN;tr|E9PM31|E9PM31_HUMAN;tr|H0YEE2|H0YEE2_HUMAN","tr|E9PJK1|E9PJK1_HUMAN;tr|E9PRJ8|E9PRJ8_HUMAN;tr|H0YDL9|H0YDL9_HUMAN;tr|H0YDJ9|H0YDJ9_HUMAN;sp|P60033|CD81_HUMAN;tr|E9PIF1|E9PIF1_HUMAN;tr|A6NMH8|A6NMH8_HUMAN;tr|E9PM31|E9PM31_HUMAN;tr|H0YEE2|H0YEE2_HUMAN",1233,"E9PJK1","E9PJK1_HUMAN","Tetraspanin {ECO:0000256|RuleBase:RU361218}",null,"CD81"]
["18.0472","16.711","18.0323","18.5214",{"$nulls":4},"RNA binding","cytosol;nucleolus;nucleus;protein complex",{"$nulls":3},5,5,5,"12.9","12.9","12.9","61.728",0,"5.5785",136840000,6,"0.475968","0.528423","-0.897752","-1.26189","sp|Q9NUQ6|SPS2L_HUMAN;tr|A0A0A0MSG5|A0A0A0MSG5_HUMAN;tr|B8ZZZ7|B8ZZZ7_HUMAN;tr|C9IZC3|C9IZC3_HUMAN;tr|C9J8M7|C9J8M7_HUMAN;tr|F2Z2S1|F2Z2S1_HUMAN;tr|C9JKE4|C9JKE4_HUMAN;tr|F8VZ02|F8VZ02_HUMAN;tr|F8VT91|F8VT91_HUMAN;tr|C9JGM8|C9JGM8_HUMAN;tr|F8W6C2|F8W6C2_HUMAN;tr|Q4ZFW0|Q4ZFW0_HUMAN;tr|F8WAV0|F8WAV0_HUMAN;tr|C9JW67|C9JW67_HUMAN","sp|Q9NUQ6|SPS2L_HUMAN;tr|A0A0A0MSG5|A0A0A0MSG5_HUMAN;tr|B8ZZZ7|B8ZZZ7_HUMAN",2708,"Q9NUQ6","SPS2L_HUMAN","SPATS2-like protein",null,"SPATS2L"]
["14.0329","13.3106","14.8561","14.2829",{"$nulls":3},"anterograde axonal transport;axonal transport of mitochondrion;cell differentiation;cytokinetic process;cytoskeleton-dependent cytokinesis;ER to Golgi vesicle-mediated transport;exit from mitosis;membrane fission;metabolic process;microtubule bundle formation;microtubule severing;mitotic cytokinesis;mitotic spindle disassembly;nervous system development;nuclear envelope reassembly;positive regulation of cytokinesis;protein hexamerization;protein homooligomerization","alpha-tubulin binding;ATP binding;beta-tubulin binding;microtubule binding;microtubule-severing ATPase activity;protein complex binding","axon cytoplasm;cytoplasm;cytoplasmic vesicle;cytosol;endoplasmic reticulum membrane;endoplasmic reticulum tubular network;endosome;extracellular exosome;lipid droplet;microtubule;microtubule organizing center;midbody;nuclear membrane;nucleoplasm;nucleus;perinuclear region of cytoplasm;spindle",{"$nulls":3},1,1,1,"3.9","3.9","3.9","67.196",0,"5.3266",8777400,2,"0.719259","0.356031","-0.897755","-1.94728","sp|Q9UBP0|SPAST_HUMAN","sp|Q9UBP0|SPAST_HUMAN",2804,"Q9UBP0","SPAST_HUMAN","Spastin {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000303|PubMed:10610178}"]
["17.8814","17.5276","18.6858","18.5192",{"$nulls":3},"cellular glucose homeostasis;glycolytic process","ATP binding;glucose binding;hexokinase activity","cell",{"$nulls":3},3,3,3,"4.5","4.5","4.5","98.972",0,"15.301",124020000,10,"1.35393","0.336681","-0.897984","-4.59372","tr|E9PB90|E9PB90_HUMAN;sp|P52789|HXK2_HUMAN","tr|E9PB90|E9PB90_HUMAN;sp|P52789|HXK2_HUMAN",1167,"E9PB90","E9PB90_HUMAN",null,null,"HK2"]
["20.8942","21.0442","21.7539","21.9912",{"$nulls":9},1,1,1,28,28,28,"5.8183",0,"32.089",86212000,9,"1.63269","0.327658","-0.903351","-6.43653","tr|J3KQY4|J3KQY4_HUMAN;tr|D6RHZ1|D6RHZ1_HUMAN;tr|D6RIH3|D6RIH3_HUMAN;tr|D6RCE9|D6RCE9_HUMAN;tr|D6RD44|D6RD44_HUMAN;tr|A2RQR6|A2RQR6_HUMAN;sp|Q96EI5|TCAL4_HUMAN","tr|J3KQY4|J3KQY4_HUMAN;tr|D6RHZ1|D6RHZ1_HUMAN;tr|D6RIH3|D6RIH3_HUMAN;tr|D6RCE9|D6RCE9_HUMAN;tr|D6RD44|D6RD44_HUMAN;tr|A2RQR6|A2RQR6_HUMAN;sp|Q96EI5|TCAL4_HUMAN",2260,"J3KQY4","J3KQY4_HUMAN",null,null,"TCEAL4"]
["22.6655","22.9121","23.7446","23.6411",{"$nulls":3},"autophagy;cell separation after cytokinesis;endosomal transport;exit from mitosis;macroautophagy;maintenance of lens transparency;membrane fission;mitotic cytokinesis;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of autophagosome assembly;negative regulation of cell death;negative regulation of neuron death;nuclear envelope reassembly;nucleus organization;positive regulation of viral release from host cell;posttranslational protein targeting to endoplasmic reticulum membrane;protein homooligomerization;regulation of centrosome duplication;regulation of mitotic spindle assembly;regulation of viral process;ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;vacuolar transport;viral budding;viral budding via host ESCRT complex;viral life cycle","cadherin binding;identical protein binding;protein homodimerization activity","cytoplasm;cytoplasmic side of plasma membrane;cytosol;endosome;ESCRT III complex;extracellular exosome;late endosome membrane;membrane coat;midbody;nuclear envelope;nucleus;vesicle","Endocytosis;Necroptosis",null,null,6,6,6,"37.9","37.9","37.9","24.95",0,"165.9",1619000000,55,"1.6739","0.3408","-0.904053","-6.76024","sp|Q9H444|CHM4B_HUMAN","sp|Q9H444|CHM4B_HUMAN",2594,"Q9H444","CHM4B_HUMAN","Charged multivesicular body protein 4b",null,"CHMP4B"]
["20.3225","20.0274","21.4788","20.6799",{"$nulls":3},"negative regulation of endoribonuclease activity;regulation of type I interferon-mediated signaling pathway;ribosomal subunit export from nucleus;translational initiation;translational termination;viral process","ATP binding;ATPase activity;endoribonuclease inhibitor activity;iron ion binding;ribosomal small subunit binding","cytoplasm;cytosol;membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},7,7,7,"17.7","17.7","17.7","67.314",0,"221.63",523190000,30,"0.775693","0.337401","-0.904416","-2.12412","sp|P61221|ABCE1_HUMAN;tr|D6R9I9|D6R9I9_HUMAN;tr|H0Y990|H0Y990_HUMAN;tr|D6RGF4|D6RGF4_HUMAN","sp|P61221|ABCE1_HUMAN;tr|D6R9I9|D6R9I9_HUMAN",1264,"P61221","ABCE1_HUMAN","ATP-binding cassette sub-family E member 1",null,"ABCE1"]
["17.7392","17.5889","18.7643","18.3743",{"$nulls":3},"apoptotic signaling pathway;mitochondrial translational elongation;mitochondrial translational termination","GTP binding;RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,"7.3","7.3","7.3","45.566",0,"5.6682",48844000,9,"1.30649","0.33584","-0.905246","-4.33193","sp|P51398|RT29_HUMAN;tr|V9GYF7|V9GYF7_HUMAN;tr|V9GZ61|V9GZ61_HUMAN;tr|V9GYW1|V9GYW1_HUMAN;tr|V9GYA7|V9GYA7_HUMAN;tr|V9GYJ9|V9GYJ9_HUMAN;tr|V9GYL9|V9GYL9_HUMAN","sp|P51398|RT29_HUMAN;tr|V9GYF7|V9GYF7_HUMAN;tr|V9GZ61|V9GZ61_HUMAN;tr|V9GYW1|V9GYW1_HUMAN;tr|V9GYA7|V9GYA7_HUMAN;tr|V9GYJ9|V9GYJ9_HUMAN;tr|V9GYL9|V9GYL9_HUMAN",1133,"P51398","RT29_HUMAN","28S ribosomal protein S29, mitochondrial","29mt;RP-S29","DAP3"]
["18.5048","18.5778","20.0908","18.8067",{"$nulls":9},8,8,8,"8.3","8.3","8.3","118.7",0,"21.298",230280000,25,"0.532144","0.49727","-0.907469","-1.41112","tr|A0A024RCR6|A0A024RCR6_HUMAN;tr|A0A0G2JK23|A0A0G2JK23_HUMAN;sp|P46379|BAG6_HUMAN;tr|A0A0G2JL47|A0A0G2JL47_HUMAN;tr|H0Y710|H0Y710_HUMAN;tr|F6S6P2|F6S6P2_HUMAN;tr|X6REW1|X6REW1_HUMAN;tr|A0A0G2JJM1|A0A0G2JJM1_HUMAN;tr|F6UR09|F6UR09_HUMAN;tr|F6U1F2|F6U1F2_HUMAN;tr|F6XTU0|F6XTU0_HUMAN;tr|A0A0G2JJR8|A0A0G2JJR8_HUMAN;tr|A0A0K0K1A2|A0A0K0K1A2_HUMAN;tr|F6WML8|F6WML8_HUMAN;tr|F6VEM6|F6VEM6_HUMAN;tr|F6X9W3|F6X9W3_HUMAN;tr|F6U341|F6U341_HUMAN;tr|H0Y4L1|H0Y4L1_HUMAN;tr|F6TC96|F6TC96_HUMAN","tr|A0A024RCR6|A0A024RCR6_HUMAN;tr|A0A0G2JK23|A0A0G2JK23_HUMAN;sp|P46379|BAG6_HUMAN;tr|A0A0G2JL47|A0A0G2JL47_HUMAN",1027,"A0A024RCR6","A0A024RCR6_HUMAN",null,null,"BAG6"]
["15.5457","15.3231","16.492","16.1928",{"$nulls":3},"positive regulation of collagen fibril organization","procollagen galactosyltransferase activity","endoplasmic reticulum lumen;membrane","Lysine degradation;Other types of O-glycan biosynthesis",null,null,1,1,1,"2.7","2.7","2.7","71.635",0,"4.1996",22866000,5,"1.40143","0.331688","-0.907985","-4.86946","sp|Q8NBJ5|GT251_HUMAN","sp|Q8NBJ5|GT251_HUMAN",2071,"Q8NBJ5","GT251_HUMAN","Procollagen galactosyltransferase 1",null,"COLGALT1"]
["21.4687","22.9019","23.0027","23.1904",{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},3,3,3,"12.5","12.5","12.5","30.302",0,"101.18",973810000,13,"0.475587","0.529114","-0.91125","-1.26089","tr|D6R9P3|D6R9P3_HUMAN;tr|D6RD18|D6RD18_HUMAN;tr|D6RBZ0|D6RBZ0_HUMAN;tr|A0A087WZV1|A0A087WZV1_HUMAN;sp|Q99729|ROAA_HUMAN","tr|D6R9P3|D6R9P3_HUMAN;tr|D6RD18|D6RD18_HUMAN;tr|D6RBZ0|D6RBZ0_HUMAN;tr|A0A087WZV1|A0A087WZV1_HUMAN;sp|Q99729|ROAA_HUMAN",3061,"D6R9P3","D6R9P3_HUMAN",null,null,"HNRNPAB"]
["17.2423","17.8063","18.2393","18.6337",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;double-strand break repair via homologous recombination;establishment of protein localization to telomere;mitotic cell cycle checkpoint;positive regulation of telomere capping;response to ionizing radiation;snRNA transcription from RNA polymerase II promoter","DNA polymerase binding;G-rich strand telomeric DNA binding;single-stranded DNA binding","cytosol;nuclear chromosome, telomeric region;nucleoplasm;nucleus;SOSS complex",{"$nulls":3},1,1,1,"10.4","10.4","10.4","22.338","0.0097561","1.6804",14994000,2,"0.929188","0.297404","-0.91221","-2.6508","sp|Q9BQ15|SOSB1_HUMAN","sp|Q9BQ15|SOSB1_HUMAN",2410,"Q9BQ15","SOSB1_HUMAN","SOSS complex subunit B1",null,"NABP2"]
["21.2088","21.071","22.4752","21.6324",{"$nulls":3},"actin filament polymerization;Arp2/3 complex-mediated actin nucleation",null,"Arp2/3 protein complex",{"$nulls":3},2,2,2,"19.5","19.5","19.5","13.057",0,"4.3344",320290000,5,"0.780756","0.334743","-0.913877","-2.14038","tr|F8WDD7|F8WDD7_HUMAN;tr|H7C0A3|H7C0A3_HUMAN;sp|P59998|ARPC4_HUMAN;tr|F8WCF6|F8WCF6_HUMAN;tr|A0A0A6YYG9|A0A0A6YYG9_HUMAN","tr|F8WDD7|F8WDD7_HUMAN;tr|H7C0A3|H7C0A3_HUMAN;sp|P59998|ARPC4_HUMAN;tr|F8WCF6|F8WCF6_HUMAN;tr|A0A0A6YYG9|A0A0A6YYG9_HUMAN",1232,"F8WDD7","F8WDD7_HUMAN",null,null,"ARPC4"]
["16.0276","16.3525","17.4944","16.7168",{"$nulls":3},"signal transduction","phosphatase regulator activity;protein kinase binding",{"$nulls":4},3,3,3,"5.7","5.7","5.7","80.199",0,"9.9656",47145000,11,"0.790724","0.332788","-0.915551","-2.17262","tr|K7EL81|K7EL81_HUMAN;sp|Q9BZL4|PP12C_HUMAN;tr|K7ER83|K7ER83_HUMAN","tr|K7EL81|K7EL81_HUMAN;sp|Q9BZL4|PP12C_HUMAN;tr|K7ER83|K7ER83_HUMAN",2523,"K7EL81","K7EL81_HUMAN",null,null,"PPP1R12C"]
["17.1235","17.2251","19.4098","16.7726",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;cell cycle;cell division;dopamine receptor signaling pathway;G-protein coupled receptor signaling pathway;GTP metabolic process;negative regulation of adenylate cyclase activity;positive regulation of macroautophagy;protein folding;transport;vesicle fusion","GDP binding;G-protein beta/gamma-subunit complex binding;G-protein coupled receptor binding;G-protein coupled serotonin receptor binding;GTP binding;GTPase activating protein binding;GTPase activity;metal ion binding;protein domain specific binding;signal transducer activity","centrosome;cytoplasm;extracellular exosome;Golgi apparatus;heterotrimeric G-protein complex;lysosomal membrane;membrane;membrane raft;midbody;nucleolus;nucleus;plasma membrane;zymogen granule","Adrenergic signaling in cardiomyocytes;Alcoholism;Apelin signaling pathway;Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Leukocyte transendothelial migration;Long-term depression;Melanogenesis;Morphine addiction;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Serotonergic synapse;Sphingolipid signaling pathway;Toxoplasmosis",null,null,3,2,2,"12.1",9,9,"40.532",0,"5.4237",50354000,10,"0.252576","0.771036","-0.916907","-0.69486","sp|P08754|GNAI3_HUMAN","sp|P08754|GNAI3_HUMAN",571,"P08754","GNAI3_HUMAN","Guanine nucleotide-binding protein G(k) subunit alpha {ECO:0000303|PubMed:2452165}",null,"GNAI3"]
["16.9866","16.9797","18.0923","17.7096",{"$nulls":3},"activation of GTPase activity;intracellular protein transport;regulation of GTPase activity;regulation of vesicle fusion;retrograde transport, endosome to Golgi","GTPase activator activity;Rab GTPase binding","cytosol;endomembrane system;intracellular;plasma membrane",{"$nulls":3},2,2,2,"6.8","6.8","6.8","87.198",0,"41.559",46451000,11,"1.38901","0.332148","-0.9178","-4.796","sp|Q4KMP7|TB10B_HUMAN","sp|Q4KMP7|TB10B_HUMAN",1787,"Q4KMP7","TB10B_HUMAN","TBC1 domain family member 10B",null,"TBC1D10B"]
["16.1712","16.1785","17.0253","17.1632",{"$nulls":3},"autophagosome assembly;autophagy;autophagy of mitochondrion;autophagy of nucleus;C-terminal protein lipidation;macroautophagy;positive regulation of protein catabolic process;protein delipidation;protein targeting to membrane;proteolysis","cysteine-type endopeptidase activity;cysteine-type peptidase activity;endopeptidase activity","cytoplasm;cytosol","Autophagy - animal;Autophagy - other",null,null,2,2,2,"7.9","7.9","7.9","44.294","0.001107","2.7119",28048000,3,"2.25237","0.444764","-0.919421","-13.3155","sp|Q9Y4P1|ATG4B_HUMAN;tr|C9JVD5|C9JVD5_HUMAN;tr|C9J3C0|C9J3C0_HUMAN;tr|H7C2A6|H7C2A6_HUMAN;tr|C9JIK8|C9JIK8_HUMAN;tr|C9JQ72|C9JQ72_HUMAN","sp|Q9Y4P1|ATG4B_HUMAN;tr|C9JVD5|C9JVD5_HUMAN;tr|C9J3C0|C9J3C0_HUMAN;tr|H7C2A6|H7C2A6_HUMAN;tr|C9JIK8|C9JIK8_HUMAN;tr|C9JQ72|C9JQ72_HUMAN",3004,"Q9Y4P1","ATG4B_HUMAN","Cysteine protease ATG4B",null,"ATG4B"]
["17.3851","17.0225","18.0973","18.15",{"$nulls":3},"cilium movement;inner dynein arm assembly;outer dynein arm assembly","dynein intermediate chain binding","cytoplasm",{"$nulls":3},5,5,5,"9.6","9.6","9.6","93.52",0,"27.128",115920000,21,"1.42652","0.33386","-0.919849","-5.02098","sp|Q86Y56|DAAF5_HUMAN;tr|H0Y650|H0Y650_HUMAN;tr|E9PGY2|E9PGY2_HUMAN","sp|Q86Y56|DAAF5_HUMAN;tr|H0Y650|H0Y650_HUMAN",1999,"Q86Y56","DAAF5_HUMAN","Dynein assembly factor 5, axonemal {ECO:0000303|PubMed:25232951, ECO:0000312|HGNC:HGNC:26013}"]
["19.2582","17.8806","19.5076","19.4736",{"$nulls":3},"cholesterol biosynthetic process;sterol biosynthetic process","chromo shadow domain binding;delta14-sterol reductase activity;DNA binding;lamin binding;oxidoreductase activity, acting on the CH-CH group of donors;RNA binding","integral component of membrane;integral component of nuclear inner membrane;membrane;nuclear envelope;nuclear membrane",{"$nulls":3},3,3,3,6,6,6,"70.702",0,"13.787",82430000,14,"0.504443","0.513027","-0.921157","-1.337","sp|Q14739|LBR_HUMAN;tr|C9JXK0|C9JXK0_HUMAN","sp|Q14739|LBR_HUMAN;tr|C9JXK0|C9JXK0_HUMAN",1643,"Q14739","LBR_HUMAN","Lamin-B receptor",null,"LBR"]
["16.6519","16.1906","17.5002","17.1854",{"$nulls":3},"double-strand break repair via nonhomologous end joining;female meiosis chromosome segregation;intrinsic apoptotic signaling pathway in response to DNA damage;isotype switching;male meiosis chromosome segregation;meiotic metaphase I plate congression;meiotic spindle midzone assembly;meiotic telomere clustering;mismatch repair;negative regulation of mitotic recombination;nuclear-transcribed mRNA poly(A) tail shortening;oogenesis;positive regulation of isotype switching to IgA isotypes;positive regulation of isotype switching to IgG isotypes;resolution of meiotic recombination intermediates;somatic hypermutation of immunoglobulin genes;spermatogenesis;synapsis","ATP binding;ATPase activity;chromatin binding;guanine/thymine mispair binding","chiasma;late recombination nodule;male germ cell nucleus;membrane;MutLalpha complex;nucleoplasm;nucleus;synaptonemal complex","Colorectal cancer;Endometrial cancer;Fanconi anemia pathway;Gastric cancer;Mismatch repair;Pathways in cancer;Platinum drug resistance",null,null,2,2,2,3,3,3,"84.6",0,"4.6209",69627000,11,"1.09251","0.309624","-0.92157","-3.30075","sp|P40692|MLH1_HUMAN;tr|F2Z298|F2Z298_HUMAN;tr|E9PF25|E9PF25_HUMAN;tr|H0Y818|H0Y818_HUMAN","sp|P40692|MLH1_HUMAN;tr|F2Z298|F2Z298_HUMAN;tr|E9PF25|E9PF25_HUMAN;tr|H0Y818|H0Y818_HUMAN",972,"P40692","MLH1_HUMAN","DNA mismatch repair protein Mlh1",null,"MLH1"]
["19.6688","19.1991","20.8496","19.8645",{"$nulls":9},1,1,1,"19.7","19.7","19.7","7.8114",0,"12.943",54456000,3,"0.63301","0.409985","-0.923081","-1.69155","tr|H7C466|H7C466_HUMAN;sp|Q8WU90|ZC3HF_HUMAN","tr|H7C466|H7C466_HUMAN;sp|Q8WU90|ZC3HF_HUMAN",2134,"H7C466","H7C466_HUMAN",null,null,"ZC3H15"]
["18.0582","18.1174","19.321","18.7012",{"$nulls":9},4,2,2,"8.3","5.1","5.1","61.163",0,"4.3532",97246000,8,"1.0117","0.297128","-0.923345","-2.96627","tr|A0A087WXZ3|A0A087WXZ3_HUMAN;sp|Q9Y5A9|YTHD2_HUMAN;tr|S4R3J8|S4R3J8_HUMAN;tr|S4R3V3|S4R3V3_HUMAN","tr|A0A087WXZ3|A0A087WXZ3_HUMAN;sp|Q9Y5A9|YTHD2_HUMAN",3014,"A0A087WXZ3"]
["18.5153","18.1587","19.5787","18.9436",{"$nulls":3},"cellular respiration;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;negative regulation of cell growth;negative regulation of intrinsic apoptotic signaling pathway;reactive oxygen species metabolic process;substantia nigra development","electron transfer activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity","mitochondrial matrix;mitochondrial membrane;mitochondrial respiratory chain complex I;mitochondrion;myelin sheath;nuclear body","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,2,2,2,"11.4","11.4","11.4","30.241",0,"24.017",63332000,17,"0.897899","0.29971","-0.924163","-2.53746","sp|O75489|NDUS3_HUMAN;tr|E9PS48|E9PS48_HUMAN","sp|O75489|NDUS3_HUMAN;tr|E9PS48|E9PS48_HUMAN",349,"O75489","NDUS3_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial",null,"NDUFS3"]
["15.8096","14.7519","16.0442","16.3661",{"$nulls":3},"double-strand break repair via homologous recombination;embryonic organ development;homeostasis of number of cells;multicellular organism growth;positive regulation of epithelial cell proliferation;protein deubiquitination;regulation of protein monoubiquitination;seminiferous tubule development;single fertilization;skeletal system morphogenesis;skin development;spermatogenesis;viral process","thiol-dependent ubiquitinyl hydrolase activity","intracellular membrane-bounded organelle;late endosome;lysosome;nucleoplasm;nucleus","Fanconi anemia pathway",null,null,2,2,2,"4.6","4.6","4.6","76.21","0.0011157","2.7599",18342000,3,"0.626291","0.417712","-0.924456","-1.67229","sp|Q8TAF3|WDR48_HUMAN","sp|Q8TAF3|WDR48_HUMAN",2105,"Q8TAF3","WDR48_HUMAN","WD repeat-containing protein 48",null,"WDR48"]
["13.0005","12.6937","14.5642","12.979",{"$nulls":3},"cell division;chromosome segregation;mitotic cell cycle;sister chromatid cohesion",null,"chromosome, centromeric region;condensed chromosome kinetochore;cytosol;membrane;Ndc80 complex;nucleus",{"$nulls":3},1,1,1,"3.7","3.7","3.7","54.303","0.0011029","2.6624",5316300,1,"0.430972","0.578733","-0.924499","-1.14513","sp|Q9BZD4|NUF2_HUMAN","sp|Q9BZD4|NUF2_HUMAN",2515,"Q9BZD4","NUF2_HUMAN","Kinetochore protein Nuf2","Nuf2;Nuf2R;sNuf2","NUF2"]
["17.6973","15.8527","18.2349","17.1645",{"$nulls":3},"deoxyribose phosphate catabolic process;galactose catabolic process;glucose metabolic process;glycogen biosynthetic process;glycogen catabolic process;neutrophil degranulation;pentose-phosphate shunt","magnesium ion binding;phosphoglucomutase activity;phosphopentomutase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;secretory granule lumen","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways;Pentose phosphate pathway;Purine metabolism;Starch and sucrose metabolism",null,null,2,2,2,"3.9","3.9","3.9","68.283",0,"4.5456",56625000,6,"0.321231","0.708792","-0.924689","-0.867146","sp|Q96G03|PGM2_HUMAN","sp|Q96G03|PGM2_HUMAN",2273,"Q96G03","PGM2_HUMAN","Phosphoglucomutase-2","GM 2","PGM2"]
["17.0691","17.1318","17.7951","18.2568",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion",{"$nulls":3},1,1,1,4,4,4,"29.45",0,"7.3712",23983000,6,"1.23731","0.318336","-0.925514","-3.97313","sp|Q9HD33|RM47_HUMAN","sp|Q9HD33|RM47_HUMAN",2650,"Q9HD33","RM47_HUMAN","39S ribosomal protein L47, mitochondrial","47mt;RP-L47","MRPL47"]
["14.1","14.27","15.6065","14.616",{"$nulls":3},"maturation of SSU-rRNA;positive regulation of ribosomal small subunit export from nucleus;positive regulation of rRNA processing;ribosomal small subunit biogenesis;rRNA processing","ATP binding;metal ion binding;protein serine/threonine kinase activity","cytoplasm;cytosol;nucleoplasm;preribosome, small subunit precursor","Ribosome biogenesis in eukaryotes",null,null,2,2,2,"5.1","5.1","5.1","63.282",0,"5.6708",10072000,4,"0.684848","0.376621","-0.926215","-1.84327","sp|Q9BVS4|RIOK2_HUMAN;tr|H0Y919|H0Y919_HUMAN","sp|Q9BVS4|RIOK2_HUMAN;tr|H0Y919|H0Y919_HUMAN",2474,"Q9BVS4","RIOK2_HUMAN","Serine/threonine-protein kinase RIO2",null,"RIOK2"]
[1,"14.6734","16.5259",1,{"$nulls":3},"ATP hydrolysis coupled proton transport","proton-transporting ATP synthase activity, rotational mechanism;proton-transporting ATPase activity, rotational mechanism","integral component of membrane;proton-transporting V-type ATPase, V1 domain",{"$nulls":3},1,1,1,"6.4","6.4","6.4","31.61","0.0056837","1.8782",6674000,1,"0.0283491","0.966797","-0.926277","-0.089545","tr|A0A0C4DGX8|A0A0C4DGX8_HUMAN;sp|Q15904|VAS1_HUMAN","tr|A0A0C4DGX8|A0A0C4DGX8_HUMAN;sp|Q15904|VAS1_HUMAN",1728,"A0A0C4DGX8","A0A0C4DGX8_HUMAN"]
["23.643","24.0715","24.9475","24.6201",{"$nulls":3},"translation","structural constituent of ribosome","cytosol;endoplasmic reticulum;ribosome",{"$nulls":3},5,5,5,"31.4","31.4","31.4","21.879",0,"33.881",1816300000,45,"1.12338","0.309875","-0.926566","-3.43587","tr|Q5JR95|Q5JR95_HUMAN;sp|P62241|RS8_HUMAN","tr|Q5JR95|Q5JR95_HUMAN;sp|P62241|RS8_HUMAN",1292,"Q5JR95","Q5JR95_HUMAN",null,null,"RPS8"]
["22.108","22.6334","23.9431","22.6539",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;autophagy;collagen catabolic process;neutrophil degranulation;protein catabolic process;proteolysis","aspartic-type endopeptidase activity;cysteine-type endopeptidase activity;serine-type endopeptidase activity","extracellular exosome;extracellular region;extracellular space;ficolin-1-rich granule lumen;lysosomal lumen;lysosome;melanosome;membrane raft;specific granule lumen;tertiary granule lumen","Apoptosis;Autophagy - animal;Estrogen signaling pathway;Lysosome;Sphingolipid signaling pathway;Tuberculosis",null,null,12,12,12,"36.7","36.7","36.7","44.552",0,"217.39",1367600000,67,"0.50289","0.513948","-0.927776","-1.33288","sp|P07339|CATD_HUMAN;tr|H7C469|H7C469_HUMAN;tr|C9JH19|C9JH19_HUMAN;tr|F8WD96|F8WD96_HUMAN;tr|H7C1V0|H7C1V0_HUMAN;tr|F8W787|F8W787_HUMAN","sp|P07339|CATD_HUMAN;tr|H7C469|H7C469_HUMAN;tr|C9JH19|C9JH19_HUMAN;tr|F8WD96|F8WD96_HUMAN",541,"P07339","CATD_HUMAN","Cathepsin D",null,"CTSD"]
["15.2716","15.0085","16.25","15.8887",{"$nulls":3},"neuron projection development",null,"growth cone;plasma membrane",{"$nulls":3},3,3,3,"4.2","4.2","4.2","102.4",0,"7.6743",35095000,9,"1.27369","0.32827","-0.929262","-4.15853","sp|Q7Z2K8|GRIN1_HUMAN","sp|Q7Z2K8|GRIN1_HUMAN",1941,"Q7Z2K8","GRIN1_HUMAN","G protein-regulated inducer of neurite outgrowth 1","RIN1","GPRIN1"]
["20.4224","18.954","20.4904","20.753",{"$nulls":3},"cell cycle;cellular response to DNA damage stimulus;formation of translation preinitiation complex;IRES-dependent viral translational initiation;positive regulation of cell proliferation;regulation of growth;regulation of transcription, DNA-templated;ribosome disassembly;transcription, DNA-templated;translation reinitiation","translation initiation factor activity","cytosol;plasma membrane",{"$nulls":3},4,4,4,"29.8","29.8","29.8","20.555",0,"5.2089",122120000,11,"0.472025","0.532586","-0.933484","-1.25157","sp|Q9ULC4|MCTS1_HUMAN","sp|Q9ULC4|MCTS1_HUMAN",2889,"Q9ULC4","MCTS1_HUMAN","Malignant T-cell-amplified sequence 1","CT-1","MCTS1"]
["19.4405","19.5064","20.5215","20.2973",{"$nulls":9},3,3,3,11,11,11,"47.761",0,"12.931",167470000,12,"1.81709","0.378479","-0.935942","-8.00826","tr|H0YKH0|H0YKH0_HUMAN;tr|H0YLW9|H0YLW9_HUMAN;tr|H0YLI3|H0YLI3_HUMAN;tr|F5H7D6|F5H7D6_HUMAN;tr|H0YNT2|H0YNT2_HUMAN;tr|A0A0D9SES8|A0A0D9SES8_HUMAN;sp|Q04726|TLE3_HUMAN;tr|H0YKT5|H0YKT5_HUMAN;tr|H0YKN8|H0YKN8_HUMAN;tr|H0YL70|H0YL70_HUMAN;tr|H0YNI7|H0YNI7_HUMAN","tr|H0YKH0|H0YKH0_HUMAN;tr|H0YLW9|H0YLW9_HUMAN;tr|H0YLI3|H0YLI3_HUMAN;tr|F5H7D6|F5H7D6_HUMAN;tr|H0YNT2|H0YNT2_HUMAN;tr|A0A0D9SES8|A0A0D9SES8_HUMAN;sp|Q04726|TLE3_HUMAN;tr|H0YKT5|H0YKT5_HUMAN;tr|H0YKN8|H0YKN8_HUMAN;tr|H0YL70|H0YL70_HUMAN",1445,"H0YKH0","H0YKH0_HUMAN",null,null,"TLE3"]
["20.3629","20.6297","21.5592","21.3059",{"$nulls":3},"translational initiation;viral translational termination-reinitiation","RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex;fibrillar center;membrane;nucleoplasm",{"$nulls":3},8,8,8,19,19,19,"66.726",0,"135.52",682130000,43,"1.43768","0.331858","-0.936205","-5.08968","sp|Q9Y262|EIF3L_HUMAN;tr|B0QY89|B0QY89_HUMAN;tr|C9JHP4|C9JHP4_HUMAN;tr|C9K0Q7|C9K0Q7_HUMAN;tr|B0QY90|B0QY90_HUMAN;tr|H7C3A0|H7C3A0_HUMAN","sp|Q9Y262|EIF3L_HUMAN;tr|B0QY89|B0QY89_HUMAN;tr|C9JHP4|C9JHP4_HUMAN;tr|C9K0Q7|C9K0Q7_HUMAN;tr|B0QY90|B0QY90_HUMAN",2939,"Q9Y262","EIF3L_HUMAN","Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011}","IF3l {ECO:0000255|HAMAP-Rule:MF_03011}","EIF3L"]
["21.8341","22.0604","22.9775","22.7895",{"$nulls":3},"cell death;COPII-coated vesicle budding;ER to Golgi vesicle-mediated transport;membrane fusion;negative regulation by host of viral genome replication;neuron projection development;neutrophil degranulation;positive regulation by host of viral genome replication;positive regulation by host of viral release from host cell;positive regulation of I-kappaB kinase/NF-kappaB signaling;protein localization to endoplasmic reticulum;sphingolipid biosynthetic process","cadherin binding;FFAT motif binding;microtubule binding;protein domain specific binding;protein heterodimerization activity;signal transducer activity","azurophil granule membrane;bicellular tight junction;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane;integral component of membrane;microtubule cytoskeleton;nuclear membrane;plasma membrane;vesicle","Cholesterol metabolism",null,null,6,6,5,"34.1","34.1","29.3","27.893",0,"49.178",800090000,47,"1.62335","0.326492","-0.936274","-6.36522","sp|Q9P0L0|VAPA_HUMAN;tr|J3QKM9|J3QKM9_HUMAN","sp|Q9P0L0|VAPA_HUMAN",2774,"Q9P0L0","VAPA_HUMAN","Vesicle-associated membrane protein-associated protein A","AMP-A;AMP-associated protein A;AP-A","VAPA"]
["19.8766","18.9952","20.8169","19.9282",{"$nulls":3},"DNA packaging;internal protein amino acid acetylation;negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric;N-terminal peptidyl-glutamic acid acetylation;N-terminal peptidyl-serine acetylation;N-terminal protein amino acid acetylation;protein acetylation","N-acetyltransferase activity;peptide alpha-N-acetyltransferase activity;peptide-glutamate-N-acetyltransferase activity;peptide-serine-N-acetyltransferase activity","cytoplasm;cytosol;cytosolic ribosome;intracellular;membrane;NatA complex;nucleolus;nucleus",{"$nulls":3},3,3,3,"15.7","15.7","15.7","26.458",0,"19.234",186950000,5,"0.563566","0.470884","-0.936619","-1.4966","sp|P41227|NAA10_HUMAN;tr|H0Y8T0|H0Y8T0_HUMAN;tr|C9JN83|C9JN83_HUMAN;tr|C9JW55|C9JW55_HUMAN;tr|F8W808|F8W808_HUMAN;tr|A8MWP7|A8MWP7_HUMAN;sp|Q9BSU3|NAA11_HUMAN","sp|P41227|NAA10_HUMAN",982,"P41227","NAA10_HUMAN","N-alpha-acetyltransferase 10",null,"NAA10"]
["16.1561","15.519","17.4882","16.0617",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytosol;nucleus;Ski complex","RNA degradation",null,null,2,2,2,4,4,4,"137.75",0,"13.189",54748000,9,"0.452224","0.551909","-0.937397","-1.20001","sp|Q15477|SKIV2_HUMAN","sp|Q15477|SKIV2_HUMAN",1707,"Q15477","SKIV2_HUMAN","Helicase SKI2W","ki2","SKIV2L"]
["20.1782","19.8609","21.284","20.6301",{"$nulls":9},1,1,1,"36.8","36.8","36.8","3.9695","0.0010718","2.392",28060000,5,"0.909659","0.294574","-0.937474","-2.57967","tr|D7F472|D7F472_HUMAN;tr|F8WEM2|F8WEM2_HUMAN;sp|Q9UDX3|S14L4_HUMAN","tr|D7F472|D7F472_HUMAN;tr|F8WEM2|F8WEM2_HUMAN;sp|Q9UDX3|S14L4_HUMAN",2816,"D7F472","D7F472_HUMAN",null,null,"SEC14L4"]
["18.7879","15.9777","18.9526","17.6884",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;cell redox homeostasis;cellular response to angiotensin;cellular response to gamma radiation;cellular response to glucose stimulus;cellular response to L-glutamine;cellular response to mechanical stimulus;cellular response to organic cyclic compound;cellular response to oxidative stress;cellular response to tumor necrosis factor;cytochrome complex assembly;hydrogen peroxide biosynthetic process;inflammatory response;innate immune response;negative regulation of glomerular filtration by angiotensin;neutrophil degranulation;oxidation-reduction process;positive regulation of cell growth;positive regulation of defense response to bacterium;positive regulation of endothelial cell proliferation;positive regulation of interleukin-6 production;positive regulation of mucus secretion;positive regulation of NAD(P)H oxidase activity;positive regulation of phagocytosis;positive regulation of reactive oxygen species biosynthetic process;positive regulation of smooth muscle cell proliferation;positive regulation of superoxide anion generation;positive regulation of toll-like receptor 2 signaling pathway;positive regulation of tumor necrosis factor production;regulation of release of sequestered calcium ion into cytosol;respiratory burst;response to activity;response to aldosterone;response to drug;response to hypoxia;response to interleukin-1;response to nutrient levels;smooth muscle hypertrophy;superoxide anion generation;superoxide metabolic process;vascular endothelial growth factor receptor signaling pathway","electron transfer activity;heme binding;metal ion binding;protein heterodimerization activity;SH3 domain binding;superoxide-generating NADPH oxidase activity","apical plasma membrane;dendrite;endoplasmic reticulum membrane;endosome;focal adhesion;Golgi apparatus;membrane;mitochondrion;NADPH oxidase complex;neuronal cell body;nucleus;perinuclear endoplasmic reticulum;phagocytic vesicle membrane;plasma membrane;secretory granule;specific granule membrane;stress fiber;tertiary granule membrane","Fluid shear stress and atherosclerosis;Leishmaniasis;Leukocyte transendothelial migration;NOD-like receptor signaling pathway;Osteoclast differentiation;Phagosome",null,null,3,3,3,"28.7","28.7","28.7","21.012","0.0027749","2.1778",61539000,2,"0.218455","0.801791","-0.937683","-0.608595","sp|P13498|CY24A_HUMAN","sp|P13498|CY24A_HUMAN",656,"P13498","CY24A_HUMAN","Cytochrome b-245 light chain",null,"CYBA"]
["17.844","17.4153","18.863","18.2727",{"$nulls":3},"alpha-linolenic acid metabolic process;fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA oxidase;linoleic acid metabolic process;long-chain fatty acid catabolic process;peroxisomal long-chain fatty acid import;peroxisomal membrane transport;peroxisome organization;transmembrane transport;very long-chain fatty acid catabolic process","ATP binding;ATPase activity;ATPase activity, coupled to transmembrane movement of substances;enzyme binding;identical protein binding;long-chain fatty acid transporter activity;protein homodimerization activity;transporter activity","cytoplasm;cytosol;integral component of peroxisomal membrane;membrane;mitochondrion;perinuclear region of cytoplasm;peroxisomal membrane;peroxisome","ABC transporters;Peroxisome",null,null,3,3,3,"6.4","6.4","6.4","82.936",0,"18.597",111630000,21,"0.907583","0.294506","-0.938244","-2.57219","sp|P33897|ABCD1_HUMAN","sp|P33897|ABCD1_HUMAN",910,"P33897","ABCD1_HUMAN","ATP-binding cassette sub-family D member 1",null,"ABCD1"]
["21.1066","22.2945","22.883","22.3957",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},3,3,3,35,35,35,"11.075",0,"7.1916",363410000,7,"0.550992","0.478081","-0.938787","-1.46221","tr|M0R3H0|M0R3H0_HUMAN;sp|P62249|RS16_HUMAN;tr|M0R1M5|M0R1M5_HUMAN;tr|M0R210|M0R210_HUMAN;tr|Q6IPX4|Q6IPX4_HUMAN;tr|M0QX76|M0QX76_HUMAN;tr|A0A087WZ27|A0A087WZ27_HUMAN","tr|M0R3H0|M0R3H0_HUMAN;sp|P62249|RS16_HUMAN;tr|M0R1M5|M0R1M5_HUMAN;tr|M0R210|M0R210_HUMAN;tr|Q6IPX4|Q6IPX4_HUMAN",1294,"M0R3H0","M0R3H0_HUMAN",null,null,"RPS16"]
["21.7784","23.0411","23.8425","22.856",{"$nulls":3},"translation","structural constituent of ribosome","large ribosomal subunit",{"$nulls":3},5,5,5,"24.3","24.3","24.3","19.586",0,"47.355",818410000,16,"0.441629","0.562788","-0.939497","-1.17259","tr|A0A087WXM6|A0A087WXM6_HUMAN;tr|J3QQT2|J3QQT2_HUMAN;tr|J3KRX5|J3KRX5_HUMAN;sp|P18621|RL17_HUMAN;tr|A0A0A6YYL6|A0A0A6YYL6_HUMAN;tr|J3QLC8|J3QLC8_HUMAN;tr|A0A0A0MRF8|A0A0A0MRF8_HUMAN;tr|J3KRB3|J3KRB3_HUMAN;tr|A0A087WWH0|A0A087WWH0_HUMAN;tr|J3QS96|J3QS96_HUMAN;tr|J3KSJ0|J3KSJ0_HUMAN;tr|A0A087WY81|A0A087WY81_HUMAN","tr|A0A087WXM6|A0A087WXM6_HUMAN;tr|J3QQT2|J3QQT2_HUMAN;tr|J3KRX5|J3KRX5_HUMAN;sp|P18621|RL17_HUMAN;tr|A0A0A6YYL6|A0A0A6YYL6_HUMAN;tr|J3QLC8|J3QLC8_HUMAN;tr|A0A0A0MRF8|A0A0A0MRF8_HUMAN",722,"A0A087WXM6","A0A087WXM6_HUMAN",null,null,"RPL17"]
["17.7667","17.0348","18.8522","17.8288",{"$nulls":3},"cellular response to misfolded protein;DNA repair;endoplasmic reticulum unfolded protein response;ERBB2 signaling pathway;negative regulation of protein binding;negative regulation of transforming growth factor beta receptor signaling pathway;positive regulation of chaperone-mediated protein complex assembly;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein ubiquitination;positive regulation of ubiquitin-protein transferase activity;proteasome-mediated ubiquitin-dependent protein catabolic process;protein autoubiquitination;protein K63-linked ubiquitination;protein maturation;protein polyubiquitination;protein quality control for misfolded or incompletely synthesized proteins;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of glucocorticoid metabolic process;regulation of protein stability;ubiquitin-dependent protein catabolic process;ubiquitin-dependent SMAD protein catabolic process","enzyme binding;G-protein coupled receptor binding;Hsp70 protein binding;Hsp90 protein binding;kinase binding;misfolded protein binding;protein binding, bridging;protein homodimerization activity;SMAD binding;TPR domain binding;ubiquitin protein ligase activity;ubiquitin protein ligase activity involved in ERAD pathway;ubiquitin protein ligase binding;ubiquitin-protein transferase activity;ubiquitin-ubiquitin ligase activity","cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;nuclear inclusion body;nucleoplasm;ubiquitin conjugating enzyme complex;ubiquitin ligase complex;Z disc","Protein processing in endoplasmic reticulum;Ubiquitin mediated proteolysis",null,null,5,5,5,"19.5","19.5","19.5","34.856",0,"6.8124",76612000,8,"0.562522","0.47058","-0.93974","-1.49374","sp|Q9UNE7|CHIP_HUMAN;tr|H3BTA3|H3BTA3_HUMAN;tr|H3BUD0|H3BUD0_HUMAN;tr|H3BS86|H3BS86_HUMAN","sp|Q9UNE7|CHIP_HUMAN;tr|H3BTA3|H3BTA3_HUMAN",2908,"Q9UNE7","CHIP_HUMAN","E3 ubiquitin-protein ligase CHIP {ECO:0000305}",null,"STUB1"]
["24.2235","24.1713","25.0375","25.2387",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},2,2,2,"24.7","24.7","24.7","9.657",0,"57.044",1666900000,21,"1.92128","0.394645","-0.940655","-9.05119","tr|H0YLP6|H0YLP6_HUMAN;tr|H0YMF4|H0YMF4_HUMAN;sp|P46779|RL28_HUMAN;tr|H0YKD8|H0YKD8_HUMAN","tr|H0YLP6|H0YLP6_HUMAN;tr|H0YMF4|H0YMF4_HUMAN;sp|P46779|RL28_HUMAN;tr|H0YKD8|H0YKD8_HUMAN",1034,"H0YLP6","H0YLP6_HUMAN",null,null,"RPL28"]
["20.7876","20.6235","22.1807","21.1137",{"$nulls":3},"tricarboxylic acid cycle","2 iron, 2 sulfur cluster binding;electron transfer activity",{"$nulls":4},3,3,3,"27.6","27.6","27.6","14.143",0,"9.1458",199090000,11,"0.651297","0.391859","-0.941607","-1.74442","tr|A0A087WXX8|A0A087WXX8_HUMAN;tr|A0A087WWT1|A0A087WWT1_HUMAN;sp|P21912|SDHB_HUMAN","tr|A0A087WXX8|A0A087WXX8_HUMAN;tr|A0A087WWT1|A0A087WWT1_HUMAN;sp|P21912|SDHB_HUMAN",757,"A0A087WXX8","A0A087WXX8_HUMAN",null,null,"SDHB"]
["17.9541","17.9057","19.1143","18.6294",{"$nulls":5},"nucleoplasm",{"$nulls":3},2,2,2,"9.7","9.7","9.7","30.824",0,"3.5112",42452000,9,"1.2156","0.321459","-0.94198","-3.86577","tr|E9PIB2|E9PIB2_HUMAN;sp|P57764|GSDMD_HUMAN;tr|G3V1A6|G3V1A6_HUMAN;tr|E9PQ48|E9PQ48_HUMAN;tr|E9PNZ0|E9PNZ0_HUMAN;tr|E9PQR9|E9PQR9_HUMAN","tr|E9PIB2|E9PIB2_HUMAN;sp|P57764|GSDMD_HUMAN;tr|G3V1A6|G3V1A6_HUMAN;tr|E9PQ48|E9PQ48_HUMAN;tr|E9PNZ0|E9PNZ0_HUMAN;tr|E9PQR9|E9PQR9_HUMAN",1230,"E9PIB2","E9PIB2_HUMAN",null,null,"GSDMD"]
["19.5153","19.2469","20.5948","20.0551",{"$nulls":3},"DNA repair;DNA replication;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","chromatin binding;DNA binding;RNA binding","chromosome;nucleolus;nucleoplasm",{"$nulls":3},7,7,7,"13.1","13.1","13.1","81.074",0,"51.262",320670000,22,"1.0525","0.303936","-0.94384","-3.13178","sp|Q08945|SSRP1_HUMAN;tr|E9PPZ7|E9PPZ7_HUMAN;tr|E9PMD4|E9PMD4_HUMAN","sp|Q08945|SSRP1_HUMAN",1477,"Q08945","SSRP1_HUMAN","FACT complex subunit SSRP1",null,"SSRP1"]
["16.5099","16.2391","18.2984","16.3555",{"$nulls":3},"protein folding","ATP binding","cytoplasm",{"$nulls":3},5,2,2,"24.9","13.8","13.8","29.736","0.0010776","2.4247",27455000,5,"0.362568","0.667092","-0.95249","-0.971082","tr|S4R3N1|S4R3N1_HUMAN;sp|Q9Y3A3|PHOCN_HUMAN;tr|B4DM50|B4DM50_HUMAN","tr|S4R3N1|S4R3N1_HUMAN",3121,"S4R3N1","S4R3N1_HUMAN",null,null,"HSPE1-MOB4"]
["24.4877","24.3128","25.6986","25.0095",{"$nulls":3},"nuclear-transcribed mRNA poly(A) tail shortening;regulation of gene expression;RNA secondary structure unwinding;translational initiation;viral process","ATP binding;ATP-dependent RNA helicase activity;double-stranded RNA binding;helicase activity;mRNA binding;RNA binding;RNA cap binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 4F complex;extracellular exosome;extracellular matrix;membrane","RNA transport",null,null,16,16,14,"46.8","46.8","42.6","46.153",0,"323.31",8604500000,124,"0.937984","0.299182","-0.953791","-2.68326","sp|P60842|IF4A1_HUMAN;tr|J3KT12|J3KT12_HUMAN;tr|J3KTB5|J3KTB5_HUMAN;tr|J3QS69|J3QS69_HUMAN;tr|J3QL43|J3QL43_HUMAN;tr|E7EQG2|E7EQG2_HUMAN;sp|Q14240|IF4A2_HUMAN;tr|J3QLN6|J3QLN6_HUMAN;tr|J3QR64|J3QR64_HUMAN;tr|J3KSZ0|J3KSZ0_HUMAN;tr|J3QKZ9|J3QKZ9_HUMAN;tr|J3KS25|J3KS25_HUMAN;tr|J3KTN0|J3KTN0_HUMAN;tr|J3KSN7|J3KSN7_HUMAN;tr|J3QL52|J3QL52_HUMAN;tr|J3KT04|J3KT04_HUMAN;tr|J3KS93|J3KS93_HUMAN;tr|E7EMV8|E7EMV8_HUMAN;tr|C9JUF0|C9JUF0_HUMAN;tr|J3QQP0|J3QQP0_HUMAN;tr|E9PBH4|E9PBH4_HUMAN;tr|F8WE11|F8WE11_HUMAN","sp|P60842|IF4A1_HUMAN;tr|J3KT12|J3KT12_HUMAN;tr|J3KTB5|J3KTB5_HUMAN;tr|J3QS69|J3QS69_HUMAN",1241,"P60842","IF4A1_HUMAN","Eukaryotic initiation factor 4A-I","IF4A-I;IF-4A-I","EIF4A1"]
["16.8406","14.6168","16.5315","16.8341",{"$nulls":4},"electron transfer activity;iron ion binding;L-ascorbic acid binding;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;procollagen-proline 4-dioxygenase activity","cytosol;endoplasmic reticulum;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;nucleoplasm","Arginine and proline metabolism;Metabolic pathways",null,null,3,3,3,"7.5","7.5","7.5","60.901",0,"4.2601",44802000,4,"0.314482","0.713864","-0.954074","-0.850222","sp|O15460|P4HA2_HUMAN;tr|C9JCP0|C9JCP0_HUMAN;tr|C9JX45|C9JX45_HUMAN;tr|A8MXE0|A8MXE0_HUMAN;tr|E7ERI1|E7ERI1_HUMAN;tr|E7ENX0|E7ENX0_HUMAN;tr|E7EPI9|E7EPI9_HUMAN","sp|O15460|P4HA2_HUMAN",223,"O15460","P4HA2_HUMAN","Prolyl 4-hydroxylase subunit alpha-2",{"$f":"-PH alpha-2","v":{"$error":"#NAME?"}},"P4HA2"]
["19.5697","19.351","20.8029","20.0259",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;positive regulation of growth rate;regulation of growth","DBD domain binding;p53 binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;mitochondrion",{"$nulls":3},5,5,5,"22.7","22.7","22.7","37.54",0,"31.667",129930000,18,"0.848182","0.308152","-0.954089","-2.36391","sp|Q8N2F6|ARM10_HUMAN;tr|H7BXQ8|H7BXQ8_HUMAN;tr|C9J5N7|C9J5N7_HUMAN;tr|A0A0J9YWR7|A0A0J9YWR7_HUMAN;tr|A0A0J9YXE4|A0A0J9YXE4_HUMAN;tr|A0A0J9YY38|A0A0J9YY38_HUMAN;tr|A0A0J9YXV5|A0A0J9YXV5_HUMAN;tr|H7C2M7|H7C2M7_HUMAN","sp|Q8N2F6|ARM10_HUMAN;tr|H7BXQ8|H7BXQ8_HUMAN;tr|C9J5N7|C9J5N7_HUMAN;tr|A0A0J9YWR7|A0A0J9YWR7_HUMAN;tr|A0A0J9YXE4|A0A0J9YXE4_HUMAN",2040,"Q8N2F6","ARM10_HUMAN","Armadillo repeat-containing protein 10",null,"ARMC10"]
["15.6539","17.0056","17.5002","17.0761",{"$nulls":4},"ATP binding;protein kinase activity",{"$nulls":4},2,2,2,"4.2","4.2","4.2","73.769",0,"5.8955",25404000,12,"0.510476","0.512888","-0.958399","-1.35305","tr|E9PG46|E9PG46_HUMAN;sp|Q2M2I8|AAK1_HUMAN","tr|E9PG46|E9PG46_HUMAN;sp|Q2M2I8|AAK1_HUMAN",1768,"E9PG46","E9PG46_HUMAN",null,null,"AAK1"]
["18.9505","18.9341","19.9845","19.8184",{"$nulls":3},"mitochondrial genome maintenance;mitochondrial translational elongation;mitochondrial translational termination","protein domain specific binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,1,1,1,"10.3","10.3","10.3","20.05",0,"9.2187",100180000,5,"2.12541","0.393962","-0.959169","-11.4883","sp|Q9NRX2|RM17_HUMAN","sp|Q9NRX2|RM17_HUMAN",2686,"Q9NRX2","RM17_HUMAN","39S ribosomal protein L17, mitochondrial","17mt;RP-L17","MRPL17"]
["17.9625","17.8517","18.9731","18.7641",{"$nulls":5},"R2TP complex",{"$nulls":3},5,5,5,"11.7","11.7","11.7","75.718",0,"12.668",163000000,27,"1.8296","0.389449","-0.961545","-8.12709","sp|Q9H6T3|RPAP3_HUMAN","sp|Q9H6T3|RPAP3_HUMAN",2605,"Q9H6T3","RPAP3_HUMAN","RNA polymerase II-associated protein 3",null,"RPAP3"]
["16.0721",1,1,"17.9963",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity",{"$nulls":4},1,1,1,"3.6","3.6","3.6","37.389",0,"4.5339",10178000,1,"0.0267743","0.967366","-0.962105","-0.0847049","tr|C9J8E1|C9J8E1_HUMAN;sp|Q16644|MAPK3_HUMAN","tr|C9J8E1|C9J8E1_HUMAN;sp|Q16644|MAPK3_HUMAN",1748,"C9J8E1","C9J8E1_HUMAN",null,null,"MAPKAPK3"]
["17.8135","18.0566","19.1921","18.606",{"$nulls":4},"ATP binding","extracellular exosome",{"$nulls":3},5,5,5,"11.3","11.3","11.3","74.977",0,"39.042",119920000,20,"1.0297","0.298318","-0.964001","-3.03849","sp|O43301|HS12A_HUMAN;tr|K7ELE6|K7ELE6_HUMAN","sp|O43301|HS12A_HUMAN",242,"O43301","HS12A_HUMAN","Heat shock 70 kDa protein 12A",null,"HSPA12A"]
["14.367","14.2043","15.5843","14.918",{"$nulls":3},"CUT catabolic process;dosage compensation by inactivation of X chromosome;histone mRNA catabolic process;maturation of 5.8S rRNA;negative regulation of telomere maintenance via telomerase;nuclear mRNA surveillance;nuclear polyadenylation-dependent rRNA catabolic process;nuclear retention of unspliced pre-mRNA at the site of transcription;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;regulation of telomerase RNA localization to Cajal body;rRNA processing","3'-5'-exoribonuclease activity;exoribonuclease activity;nucleotide binding;RNA binding;telomerase RNA binding","cytoplasm;cytosol;exosome (RNase complex);membrane;nuclear exosome (RNase complex);nucleolus;nucleoplasm;nucleus;transcriptionally active chromatin","RNA degradation",null,null,1,1,1,"1.5","1.5","1.5","100.83","0.00075301","2.837",15905000,5,"0.972996","0.298315","-0.965474","-2.81518","sp|Q01780|EXOSX_HUMAN","sp|Q01780|EXOSX_HUMAN",1419,"Q01780","EXOSX_HUMAN","Exosome component 10",null,"EXOSC10"]
["17.5389","17.085","17.4744","19.0822",{"$nulls":3},"activation of cysteine-type endopeptidase activity;activation of cysteine-type endopeptidase activity involved in apoptotic process;activation of innate immune response;apoptotic process;cellular response to interleukin-1;cellular response to lipopolysaccharide;cellular response to tumor necrosis factor;defense response to Gram-negative bacterium;defense response to virus;inflammatory response;innate immune response;interleukin-1 beta production;intrinsic apoptotic signaling pathway by p53 class mediator;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;macropinocytosis;myeloid dendritic cell activation;myeloid dendritic cell activation involved in immune response;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interferon-beta production;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein serine/threonine kinase activity;neutrophil degranulation;positive regulation of actin filament polymerization;positive regulation of activated T cell proliferation;positive regulation of adaptive immune response;positive regulation of antigen processing and presentation of peptide antigen via MHC class II;positive regulation of apoptotic process;positive regulation of chemokine secretion;positive regulation of cysteine-type endopeptidase activity;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of defense response to virus by host;positive regulation of DNA binding transcription factor activity;positive regulation of ERK1 and ERK2 cascade;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of interferon-gamma production;positive regulation of interleukin-1 beta secretion;positive regulation of interleukin-10 secretion;positive regulation of interleukin-6 production;positive regulation of interleukin-6 secretion;positive regulation of interleukin-8 secretion;positive regulation of JNK cascade;positive regulation of NF-kappaB transcription factor activity;positive regulation of phagocytosis;positive regulation of release of cytochrome c from mitochondria;positive regulation of T cell activation;positive regulation of T cell migration;positive regulation of tumor necrosis factor production;regulation of autophagy;regulation of GTPase activity;regulation of inflammatory response;regulation of intrinsic apoptotic signaling pathway;regulation of protein stability;regulation of tumor necrosis factor-mediated signaling pathway;signal transduction;tumor necrosis factor-mediated signaling pathway","BMP receptor binding;cysteine-type endopeptidase activator activity involved in apoptotic process;cysteine-type endopeptidase activity involved in apoptotic process;enzyme binding;identical protein binding;interleukin-6 receptor binding;ion channel binding;myosin I binding;protease binding;protein homodimerization activity;Pyrin domain binding;tropomyosin binding","AIM2 inflammasome complex;azurophil granule lumen;cytoplasm;cytosol;endoplasmic reticulum;extracellular region;IkappaB kinase complex;mitochondrion;neuronal cell body;NLRP1 inflammasome complex;NLRP3 inflammasome complex;nucleolus;nucleus;secretory granule lumen","C-type lectin receptor signaling pathway;Cytosolic DNA-sensing pathway;Influenza A;Legionellosis;Necroptosis;NOD-like receptor signaling pathway;Pertussis;Salmonella infection;Yersinia infection",null,null,2,2,2,"12.3","12.3","12.3","21.627",0,"4.2432",32351000,3,"0.435508","0.573382","-0.966332","-1.15681","sp|Q9ULZ3|ASC_HUMAN","sp|Q9ULZ3|ASC_HUMAN",2899,"Q9ULZ3","ASC_HUMAN","Apoptosis-associated speck-like protein containing a CARD","ASC","PYCARD"]
["18.7442","18.8455","19.2141","20.3091",{"$nulls":3},"alpha-linolenic acid metabolic process;fatty acid elongation, monounsaturated fatty acid;fatty acid elongation, polyunsaturated fatty acid;fatty acid elongation, saturated fatty acid;linoleic acid metabolic process;long-chain fatty-acyl-CoA biosynthetic process;sphingolipid biosynthetic process;very long-chain fatty acid biosynthetic process","3-oxo-arachidoyl-CoA synthase activity;3-oxo-cerotoyl-CoA synthase activity;3-oxo-lignoceronyl-CoA synthase activity;fatty acid elongase activity;very-long-chain 3-ketoacyl-CoA synthase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane","Biosynthesis of unsaturated fatty acids;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways",null,null,1,1,1,"4.3","4.3","4.3","32.662","0.0010973","2.5928",57279000,6,"0.656083","0.391196","-0.966789","-1.75837","sp|Q9BW60|ELOV1_HUMAN","sp|Q9BW60|ELOV1_HUMAN",2478,"Q9BW60","ELOV1_HUMAN","Elongation of very long chain fatty acids protein 1 {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000305}",null,"ELOVL1"]
["17.166","17.3805","18.4876","17.9949",{"$nulls":3},"NAD biosynthesis via nicotinamide riboside salvage pathway;NADH metabolic process;NADP metabolic process;nicotinamide nucleotide metabolic process;protein homotetramerization","metal ion binding;NADHX epimerase activity;NADPHX epimerase activity;nucleotide binding;protein homodimerization activity","cell body;cilium;cytosol;extracellular exosome;extracellular region;extracellular space;intracellular membrane-bounded organelle;mitochondrial matrix;mitochondrion;nucleoplasm",{"$nulls":3},1,1,1,"6.6","6.6","6.6","31.674",0,"5.6543",27828000,7,"1.16012","0.314713","-0.967956","-3.60225","sp|Q8NCW5|NNRE_HUMAN","sp|Q8NCW5|NNRE_HUMAN",2084,"Q8NCW5","NNRE_HUMAN","NAD(P)H-hydrate epimerase {ECO:0000255|HAMAP-Rule:MF_03159}",null,"NAXE"]
["18.5397","19.3355","19.9188","19.8945",{"$nulls":9},1,1,1,"9.1","9.1","9.1","11.255",0,"7.3439",27665000,6,"0.868665","0.303269","-0.969048","-2.43447","tr|H0YII4|H0YII4_HUMAN;tr|H0YI90|H0YI90_HUMAN;sp|Q5TDH0|DDI2_HUMAN","tr|H0YII4|H0YII4_HUMAN;tr|H0YI90|H0YI90_HUMAN;sp|Q5TDH0|DDI2_HUMAN",1839,"H0YII4","H0YII4_HUMAN",null,null,"DDI2"]
["17.8381","17.2793","18.5231","18.5329",{"$nulls":3},"regulation of GTPase activity;signal transduction",{"$nulls":5},7,7,7,8,8,8,"157.46",0,"19.375",203450000,21,"1.1308","0.310953","-0.969299","-3.46895","tr|F8W9S7|F8W9S7_HUMAN;sp|Q14C86|GAPD1_HUMAN;tr|B0QZ65|B0QZ65_HUMAN;tr|A0A0A0MQV8|A0A0A0MQV8_HUMAN;tr|B4DGD8|B4DGD8_HUMAN;tr|H0Y4E7|H0Y4E7_HUMAN;tr|H0Y7I9|H0Y7I9_HUMAN;tr|C9IZ08|C9IZ08_HUMAN","tr|F8W9S7|F8W9S7_HUMAN;sp|Q14C86|GAPD1_HUMAN;tr|B0QZ65|B0QZ65_HUMAN;tr|A0A0A0MQV8|A0A0A0MQV8_HUMAN;tr|B4DGD8|B4DGD8_HUMAN;tr|H0Y4E7|H0Y4E7_HUMAN;tr|H0Y7I9|H0Y7I9_HUMAN;tr|C9IZ08|C9IZ08_HUMAN",1654,"F8W9S7","F8W9S7_HUMAN",null,null,"GAPVD1"]
["16.7883","16.6777","17.8304","17.5786",{"$nulls":3},"adherens junction assembly;adherens junction organization;bundle of His cell-Purkinje myocyte adhesion involved in cell communication;cell migration;cell-cell adhesion;cellular response to indole-3-methanol;cornification;cytoskeletal anchoring at plasma membrane;desmosome assembly;detection of mechanical stimulus;endothelial cell-cell adhesion;keratinization;neutrophil degranulation;positive regulation of canonical Wnt signaling pathway;positive regulation of DNA binding transcription factor activity;positive regulation of protein import into nucleus;protein heterooligomerization;protein localization to plasma membrane;regulation of cell proliferation;regulation of heart rate by cardiac conduction;regulation of ventricular cardiac muscle cell action potential","alpha-catenin binding;cadherin binding;cell adhesion molecule binding;cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;protein homodimerization activity;protein kinase binding;protein phosphatase binding;signal transducer activity;structural constituent of cell wall;structural molecule activity;transcription coactivator activity","actin cytoskeleton;apicolateral plasma membrane;catenin complex;cell-cell adherens junction;cell-cell junction;cornified envelope;cytoplasm;cytoplasmic side of plasma membrane;cytoskeleton;cytosol;desmosome;extracellular exosome;extracellular matrix;extracellular region;fascia adherens;ficolin-1-rich granule lumen;focal adhesion;gamma-catenin-TCF7L2 complex;intercalated disc;intermediate filament;lateral plasma membrane;nucleus;plasma membrane;protein-DNA complex;specific granule lumen;Z disc;zonula adherens","Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Gastric cancer;Pathways in cancer;Transcriptional misregulation in cancer",null,null,3,2,2,"4.7",3,3,"81.744",0,"9.4868",111430000,3,"1.71102","0.341365","-0.971516","-7.06482","sp|P14923|PLAK_HUMAN;tr|C9JTX4|C9JTX4_HUMAN;tr|C9J826|C9J826_HUMAN;tr|C9JK18|C9JK18_HUMAN;tr|C9JKY1|C9JKY1_HUMAN","sp|P14923|PLAK_HUMAN",678,"P14923","PLAK_HUMAN","Junction plakoglobin",null,"JUP"]
["18.3922","18.1815","19.613","18.9085",{"$nulls":9},1,1,1,18,18,18,"10.514","0.00039308","3.2215",16518000,5,"0.928641","0.296939","-0.97385","-2.64879","tr|B1AQ61|B1AQ61_HUMAN;sp|O95155|UBE4B_HUMAN","tr|B1AQ61|B1AQ61_HUMAN;sp|O95155|UBE4B_HUMAN",412,"B1AQ61","B1AQ61_HUMAN",null,null,"UBE4B"]
["16.6936","16.5029","17.9331","17.2143",{"$nulls":9},2,2,2,"12.2","12.2","12.2","32.136",0,"5.7033",26988000,4,"0.921707","0.293588","-0.975443","-2.6234","tr|C9JA93|C9JA93_HUMAN;sp|Q8TC07|TBC15_HUMAN","tr|C9JA93|C9JA93_HUMAN;sp|Q8TC07|TBC15_HUMAN",3076,"C9JA93","C9JA93_HUMAN",null,null,"TBC1D15"]
["18.1745","18.0476","19.3959","18.7787",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;cellular response to reactive oxygen species;cytolysis in other organism;defense response to bacterium;defense response to Gram-negative bacterium;defense response to Gram-positive bacterium;killing of cells of other organism;positive regulation of cell proliferation;positive regulation of reactive oxygen species metabolic process;replicative cell aging",null,"integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},1,1,1,"21.5","21.5","21.5","8.1828",0,"3.5107",17205000,8,"1.04455","0.301307","-0.976263","-3.099","sp|P60602|ROMO1_HUMAN","sp|P60602|ROMO1_HUMAN",1238,"P60602","ROMO1_HUMAN","Reactive oxygen species modulator 1","OS modulator 1","ROMO1"]
["13.7757","13.5079","15.4598","13.7771",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"1.1","1.1","1.1","112.71","0.00075844","2.8856",9841000,5,"0.43143","0.578526","-0.976585","-1.14631","tr|A0A075B785|A0A075B785_HUMAN;sp|Q9P260|K1468_HUMAN","tr|A0A075B785|A0A075B785_HUMAN;sp|Q9P260|K1468_HUMAN",2781,"A0A075B785","A0A075B785_HUMAN",null,null,"KIAA1468"]
["20.8759","19.281","22.5958","19.5196",{"$nulls":4},"calcium ion binding",{"$nulls":4},3,3,2,"26.9","26.9","16.9","14.436",0,"7.9596",334580000,14,"0.201429","0.821407","-0.979232","-0.565199","tr|F8VPF3|F8VPF3_HUMAN;tr|F8W1R7|F8W1R7_HUMAN;sp|P60660|MYL6_HUMAN;tr|J3KND3|J3KND3_HUMAN;tr|G8JLA2|G8JLA2_HUMAN;tr|G3V1V0|G3V1V0_HUMAN;tr|B7Z6Z4|B7Z6Z4_HUMAN;tr|H0YI43|H0YI43_HUMAN;tr|F8VZU9|F8VZU9_HUMAN;tr|G3V1Y7|G3V1Y7_HUMAN;tr|F8W180|F8W180_HUMAN;tr|F8VXL3|F8VXL3_HUMAN","tr|F8VPF3|F8VPF3_HUMAN;tr|F8W1R7|F8W1R7_HUMAN;sp|P60660|MYL6_HUMAN;tr|J3KND3|J3KND3_HUMAN;tr|G8JLA2|G8JLA2_HUMAN;tr|G3V1V0|G3V1V0_HUMAN;tr|B7Z6Z4|B7Z6Z4_HUMAN;tr|H0YI43|H0YI43_HUMAN;tr|F8VZU9|F8VZU9_HUMAN;tr|G3V1Y7|G3V1Y7_HUMAN;tr|F8W180|F8W180_HUMAN",1239,"F8VPF3","F8VPF3_HUMAN",null,null,"MYL6"]
["21.4971","21.3106","22.4864","22.282",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;cellular response to nerve growth factor stimulus;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component","actin binding;structural constituent of cytoskeleton","actin cytoskeleton;Arp2/3 protein complex;cytosol;extracellular exosome;filamentous actin;focal adhesion;growth cone leading edge;lamellipodium;membrane","Bacterial invasion of epithelial cells;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,5,5,5,"30.9","30.9","30.9","20.546",0,"13.342",362950000,20,"1.71342","0.343422","-0.980344","-7.08498","sp|O15145|ARPC3_HUMAN;tr|C9JZD1|C9JZD1_HUMAN;tr|F8VR50|F8VR50_HUMAN","sp|O15145|ARPC3_HUMAN;tr|C9JZD1|C9JZD1_HUMAN",202,"O15145","ARPC3_HUMAN","Actin-related protein 2/3 complex subunit 3",null,"ARPC3"]
["22.1178","21.7046","23.2701","22.5136",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleus;rough endoplasmic reticulum","Ribosome",null,null,8,8,8,"22.5","22.5","22.5","47.697",0,"19.595",996750000,26,"0.821924","0.32214","-0.98069","-2.27531","sp|P36578|RL4_HUMAN;tr|H3BM89|H3BM89_HUMAN;tr|H3BU31|H3BU31_HUMAN;tr|H3BTP7|H3BTP7_HUMAN","sp|P36578|RL4_HUMAN;tr|H3BM89|H3BM89_HUMAN;tr|H3BU31|H3BU31_HUMAN",945,"P36578","RL4_HUMAN","60S ribosomal protein L4",null,"RPL4"]
["22.209","21.9765","23.0871","23.0697",{"$nulls":3},"purine nucleotide biosynthetic process","IMP dehydrogenase activity","cytosol",{"$nulls":3},8,8,7,"22.1","22.1","20.4","50.957",0,"94.298",1511300000,43,"1.86311","0.388391","-0.985632","-8.45389","tr|H0Y4R1|H0Y4R1_HUMAN;sp|P12268|IMDH2_HUMAN;tr|E7ETK5|E7ETK5_HUMAN;tr|C9K0R9|C9K0R9_HUMAN","tr|H0Y4R1|H0Y4R1_HUMAN;sp|P12268|IMDH2_HUMAN",643,"H0Y4R1","H0Y4R1_HUMAN",null,null,"IMPDH2"]
["15.4915","15.4011","16.3042","16.5644",{"$nulls":3},"central nervous system development;negative regulation of transcription from RNA polymerase II promoter;neuron apoptotic process;transcription, DNA-templated","DNA binding;protein domain specific binding;transcription corepressor activity","cell junction;cytoplasm;nuclear matrix;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},1,1,1,"1.1","1.1","1.1","125.41",0,"8.7249",26288000,3,"1.72388","0.350708","-0.987986","-7.17335","sp|P54259|ATN1_HUMAN","sp|P54259|ATN1_HUMAN",1190,"P54259","ATN1_HUMAN","Atrophin-1",null,"ATN1"]
["14.8317","14.6868","16.8572","14.6396",{"$nulls":3},"defense response to virus","ATP binding;ATPase activity;cadherin binding","membrane",{"$nulls":3},2,2,2,"4.7","4.7","4.7","79.744",0,"3.8709",19069000,3,"0.330426","0.702762","-0.989174","-0.890222","sp|Q9NUQ8|ABCF3_HUMAN","sp|Q9NUQ8|ABCF3_HUMAN",2709,"Q9NUQ8","ABCF3_HUMAN","ATP-binding cassette sub-family F member 3",null,"ABCF3"]
["21.1978","20.5981","22.1919","21.5839",{"$nulls":3},"negative regulation of translation;positive regulation of dendrite morphogenesis;positive regulation of dendritic spine morphogenesis","RNA binding","cytoplasmic stress granule;cytosol;dendrite;integral component of plasma membrane;membrane;P-body",{"$nulls":3},10,10,10,"27.4","27.4","27.4","78.365",0,"66.862",783290000,44,"0.834717","0.313687","-0.989945","-2.31822","sp|Q14444|CAPR1_HUMAN;tr|G3V153|G3V153_HUMAN;tr|A0A087X082|A0A087X082_HUMAN;tr|E9PLA9|E9PLA9_HUMAN","sp|Q14444|CAPR1_HUMAN;tr|G3V153|G3V153_HUMAN;tr|A0A087X082|A0A087X082_HUMAN;tr|E9PLA9|E9PLA9_HUMAN",1622,"Q14444","CAPR1_HUMAN","Caprin-1",null,"CAPRIN1"]
["18.4802","18.3827","19.6563","19.1891",{"$nulls":3},"cell division;kinetochore organization;meiotic chromosome condensation;meiotic chromosome segregation;mitotic chromosome condensation","ATP binding;protein heterodimerization activity","condensed chromosome;condensin complex;cytoplasm;cytosol;extracellular exosome;nuclear chromosome;nucleolus;nucleoplasm;nucleus",{"$nulls":3},16,16,16,17,17,17,"135.65",0,"42.95",495520000,39,"1.27265","0.327266","-0.991237","-4.15312","sp|O95347|SMC2_HUMAN;tr|A0A0C4DGE5|A0A0C4DGE5_HUMAN;tr|Q5T821|Q5T821_HUMAN","sp|O95347|SMC2_HUMAN",427,"O95347","SMC2_HUMAN","Structural maintenance of chromosomes protein 2","MC protein 2;MC-2","SMC2"]
["16.4922","16.2198","17.6688","17.0286",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay",null,"cytoplasm;cytosol;nucleoplasm;nucleus;Ski complex;transcriptionally active chromatin","RNA degradation",null,null,4,4,4,"3.1","3.1","3.1","175.48",0,"8.814",104900000,9,"0.983038","0.298592","-0.992722","-2.85384","sp|Q6PGP7|TTC37_HUMAN;tr|D6RCE2|D6RCE2_HUMAN","sp|Q6PGP7|TTC37_HUMAN;tr|D6RCE2|D6RCE2_HUMAN",1893,"Q6PGP7","TTC37_HUMAN","Tetratricopeptide repeat protein 37","PR repeat protein 37","TTC37"]
["17.6789","17.0818","18.5523","18.1941",{"$nulls":3},"activation of MAPK activity;Bergmann glial cell differentiation;cell cycle arrest;cell motility;cellular senescence;cerebellar cortex formation;chemotaxis;epithelial cell proliferation involved in lung morphogenesis;ERK1 and ERK2 cascade;face development;heart development;keratinocyte differentiation;labyrinthine layer development;MAPK cascade;movement of cell or subcellular component;negative regulation of cell proliferation;negative regulation of gene expression;neuron differentiation;peptidyl-threonine phosphorylation;placenta blood vessel development;positive regulation of axonogenesis;positive regulation of ERK1 and ERK2 cascade;positive regulation of gene expression;positive regulation of production of miRNAs involved in gene silencing by miRNA;positive regulation of protein serine/threonine kinase activity;positive regulation of transcription, DNA-templated;protein phosphorylation;proteolysis in other organism;regulation of apoptotic process;regulation of axon regeneration;regulation of early endosome to late endosome transport;regulation of Golgi inheritance;regulation of mitotic cell cycle;regulation of stress-activated MAPK cascade;signal transduction;thymus development;thyroid gland development;trachea formation","ATP binding;MAP kinase kinase activity;protein C-terminus binding;protein kinase activity;protein N-terminus binding;protein serine/threonine kinase activator activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity;signal transducer, downstream of receptor, with protein tyrosine phosphatase activity","cytosol;early endosome;endoplasmic reticulum;extracellular exosome;focal adhesion;Golgi apparatus;late endosome;microtubule organizing center;mitochondrion;nucleus;plasma membrane","Acute myeloid leukemia;Alcoholism;Apelin signaling pathway;Apoptosis;Autophagy - animal;B cell receptor signaling pathway;Bladder cancer;Breast cancer;cAMP signaling pathway;Cellular senescence;Central carbon metabolism in cancer;cGMP-PKG signaling pathway;Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;Cushing syndrome;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Focal adhesion;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;MicroRNAs in cancer;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-small cell lung cancer;Oocyte meiosis;Osteoclast differentiation;Oxytocin signaling pathway;Pancreatic cancer;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prion diseases;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Serotonergic synapse;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid cancer;Thyroid hormone signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Yersinia infection",null,null,3,2,2,"9.9","7.6","7.6","43.439",0,"4.911",43832000,3,"0.982449","0.297031","-0.992826","-2.85156","sp|Q02750|MP2K1_HUMAN;tr|H3BRW9|H3BRW9_HUMAN","sp|Q02750|MP2K1_HUMAN;tr|H3BRW9|H3BRW9_HUMAN",1431,"Q02750","MP2K1_HUMAN","Dual specificity mitogen-activated protein kinase kinase 1","AP kinase kinase 1;APKK 1;KK1","MAP2K1"]
["17.0474","17.1457","18.2147","17.9811",{"$nulls":3},"intracellular signal transduction","GTPase activator activity;metal ion binding","intracellular",{"$nulls":3},1,1,1,"2.3","2.3","2.3","84.622",0,"55.292",50523000,9,"1.80572","0.365605","-1.00135","-7.90162","tr|K7ES92|K7ES92_HUMAN;tr|F5H1R4|F5H1R4_HUMAN;sp|Q92619|HMHA1_HUMAN;tr|K7ES98|K7ES98_HUMAN;tr|K7EM85|K7EM85_HUMAN","tr|K7ES92|K7ES92_HUMAN;tr|F5H1R4|F5H1R4_HUMAN;sp|Q92619|HMHA1_HUMAN;tr|K7ES98|K7ES98_HUMAN;tr|K7EM85|K7EM85_HUMAN",2180,"K7ES92","K7ES92_HUMAN",null,null,"ARHGAP45"]
["15.7675","15.2624","16.9787","16.0648",{"$nulls":3},"ATP-dependent chromatin remodeling;transcription, DNA-templated","DNA binding transcription factor activity;sequence-specific DNA binding;zinc ion binding","nuclear chromatin;nuclear speck;nucleoplasm;protein complex",{"$nulls":3},3,2,2,"7.4","5.6","5.6","65.26",0,"4.3972",24169000,8,"0.713057","0.360823","-1.00681","-1.92832","sp|Q8WXI9|P66B_HUMAN","sp|Q8WXI9|P66B_HUMAN",2158,"Q8WXI9","P66B_HUMAN","Transcriptional repressor p66-beta",null,"GATAD2B"]
["17.583","17.5269","18.7234","18.4022",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},1,1,1,15,15,15,"14.056",0,"3.9186",19582000,9,"1.59896","0.338193","-1.00791","-6.18236","tr|K7EKI4|K7EKI4_HUMAN;tr|K7ELF1|K7ELF1_HUMAN;tr|K7ELQ0|K7ELQ0_HUMAN;tr|K7ES61|K7ES61_HUMAN;sp|Q9BYD3|RM04_HUMAN;tr|X6RAY8|X6RAY8_HUMAN","tr|K7EKI4|K7EKI4_HUMAN;tr|K7ELF1|K7ELF1_HUMAN;tr|K7ELQ0|K7ELQ0_HUMAN;tr|K7ES61|K7ES61_HUMAN;sp|Q9BYD3|RM04_HUMAN;tr|X6RAY8|X6RAY8_HUMAN",2508,"K7EKI4","K7EKI4_HUMAN",null,null,"MRPL4"]
["18.1896","18.5491","19.2084","19.547",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;insulin receptor signaling pathway;plasma membrane organization;positive regulation of actin cytoskeleton reorganization;positive regulation of actin filament polymerization;regulation of insulin receptor signaling pathway;response to bacterium","actin binding;cadherin binding involved in cell-cell adhesion;proline-rich region binding","cell-cell adherens junction;cytoskeleton;cytosol;extracellular exosome;nucleoplasm;plasma membrane",{"$nulls":3},3,3,3,"8.2","8.2","8.2","56.882",0,"50.845",166860000,11,"1.2593","0.325751","-1.00838","-4.08433","sp|Q9UHR4|BI2L1_HUMAN","sp|Q9UHR4|BI2L1_HUMAN",2839,"Q9UHR4","BI2L1_HUMAN","Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1","AI1-associated protein 2-like protein 1","BAIAP2L1"]
["18.4652","17.5937","19.595","18.482",{"$nulls":4},"peptidase activity",{"$nulls":4},2,2,2,"19.3","19.3","19.3","15.976","0.00076775","2.9899",35704000,2,"0.538261","0.487815","-1.00907","-1.42764","tr|D6RAI0|D6RAI0_HUMAN;tr|D6RGK7|D6RGK7_HUMAN;tr|D6RAZ3|D6RAZ3_HUMAN;tr|D6R9T3|D6R9T3_HUMAN;tr|E7EMP6|E7EMP6_HUMAN;sp|Q96FZ2|HMCES_HUMAN","tr|D6RAI0|D6RAI0_HUMAN;tr|D6RGK7|D6RGK7_HUMAN;tr|D6RAZ3|D6RAZ3_HUMAN;tr|D6R9T3|D6R9T3_HUMAN;tr|E7EMP6|E7EMP6_HUMAN;sp|Q96FZ2|HMCES_HUMAN",2271,"D6RAI0","D6RAI0_HUMAN","Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein {ECO:0000256|RuleBase:RU364100}","S cell-specific 5hmC-binding protein {ECO:0000256|RuleBase:RU364100}","HMCES"]
["21.5145","20.4261","22.1796","21.7871",{"$nulls":3},"IRE1-mediated unfolded protein response;small GTPase mediated signal transduction","GTP binding;signal recognition particle binding","cytoplasm;cytoplasmic microtubule;endoplasmic reticulum membrane;integral component of membrane;membrane;signal recognition particle receptor complex","Protein export",null,null,6,6,6,"30.6","30.6","30.6","29.702",0,"11.268",464630000,21,"0.653619","0.390981","-1.01304","-1.75118","sp|Q9Y5M8|SRPRB_HUMAN;tr|H7C4H2|H7C4H2_HUMAN","sp|Q9Y5M8|SRPRB_HUMAN;tr|H7C4H2|H7C4H2_HUMAN",3022,"Q9Y5M8","SRPRB_HUMAN","Signal recognition particle receptor subunit beta","R-beta","SRPRB"]
["15.005","16.0028","16.935","16.1008",{"$nulls":3},"signal transduction","phosphatidylinositol binding",{"$nulls":4},2,2,2,"2.6","2.6","2.6","104.57",0,"3.787",33500000,7,"0.586253","0.45171","-1.01401","-1.55933","tr|G3V174|G3V174_HUMAN;sp|A7KAX9|RHG32_HUMAN","tr|G3V174|G3V174_HUMAN;sp|A7KAX9|RHG32_HUMAN",110,"G3V174","G3V174_HUMAN",null,null,"ARHGAP32"]
["22.6323","21.9698","23.3332","23.2981",{"$nulls":3},"antigen processing and presentation of peptide antigen via MHC class I;calcium-mediated signaling using intracellular calcium source;ER to Golgi vesicle-mediated transport;execution phase of apoptosis;intracellular protein transport;negative regulation of endoplasmic reticulum calcium ion concentration;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cytosolic calcium ion concentration;positive regulation of ER-associated ubiquitin-dependent protein catabolic process;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial calcium ion concentration;positive regulation of retrograde protein transport, ER to cytosol;protein localization to endoplasmic reticulum exit site;spermatogenesis","MHC class I protein binding;protein complex binding","clathrin-coated vesicle;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi cisterna membrane;integral component of lumenal side of endoplasmic reticulum membrane;integral component of plasma membrane;lipid droplet;membrane;mitochondrion;perinuclear endoplasmic reticulum","Human papillomavirus infection;Protein processing in endoplasmic reticulum",null,null,8,8,8,22,22,22,"27.991",0,"43.838",1320900000,70,"1.03474","0.299725","-1.01463","-3.05893","sp|P51572|BAP31_HUMAN;tr|C9JMD7|C9JMD7_HUMAN;tr|C9JSP1|C9JSP1_HUMAN;tr|C9JQ75|C9JQ75_HUMAN;tr|C9J0M4|C9J0M4_HUMAN","sp|P51572|BAP31_HUMAN;tr|C9JMD7|C9JMD7_HUMAN;tr|C9JSP1|C9JSP1_HUMAN;tr|C9JQ75|C9JQ75_HUMAN;tr|C9J0M4|C9J0M4_HUMAN",1138,"P51572","BAP31_HUMAN","B-cell receptor-associated protein 31","ap31;CR-associated protein 31","BCAP31"]
["17.7865","16.513","18.7602","17.571",{"$nulls":4},"SH3 domain binding;structural constituent of cytoskeleton","cytoskeleton;cytosol","Pathways in cancer;Thyroid cancer",null,null,3,3,3,8,8,8,"53.29",0,"26.294",51208000,10,"0.439082","0.564381","-1.01585","-1.16602","sp|Q16204|CCDC6_HUMAN","sp|Q16204|CCDC6_HUMAN",1733,"Q16204","CCDC6_HUMAN","Coiled-coil domain-containing protein 6",null,"CCDC6"]
["15.2439","15.0359","15.8955","16.4162",{"$nulls":3},"histone H3 acetylation;histone H4 acetylation;positive regulation of interleukin-1 beta secretion;positive regulation of keratinocyte differentiation;positive regulation of retinoic acid receptor signaling pathway;positive regulation of transcription, DNA-templated;response to growth hormone;response to organophosphorus;response to retinoic acid","DNA binding;interleukin-1 binding;NACHT domain binding;zinc ion binding","cytoplasm;cytosol;plasma membrane;PML body",{"$nulls":3},4,4,4,"12.6","12.6","12.6","63.954",0,"7.1861",58448000,9,"1.16473","0.313433","-1.01591","-3.62359","sp|O95361|TRI16_HUMAN;tr|H0Y626|H0Y626_HUMAN;tr|K7EL43|K7EL43_HUMAN;tr|B3KP96|B3KP96_HUMAN;tr|J3QKY5|J3QKY5_HUMAN;tr|J3KSX4|J3KSX4_HUMAN;tr|J3QL38|J3QL38_HUMAN;tr|J3QR69|J3QR69_HUMAN;tr|C9JWX7|C9JWX7_HUMAN;tr|I3L1X9|I3L1X9_HUMAN;tr|J3QLP0|J3QLP0_HUMAN;tr|I3L3K9|I3L3K9_HUMAN;tr|K7ENN8|K7ENN8_HUMAN;sp|Q309B1|TR16L_HUMAN","sp|O95361|TRI16_HUMAN;tr|H0Y626|H0Y626_HUMAN;tr|K7EL43|K7EL43_HUMAN;tr|B3KP96|B3KP96_HUMAN;tr|J3QKY5|J3QKY5_HUMAN",428,"O95361","TRI16_HUMAN","Tripartite motif-containing protein 16",null,"TRIM16"]
["19.1749","18.9185","20.259","19.8684",{"$nulls":3},"defense response to virus;innate immune response;negative regulation of viral genome replication;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-beta production;positive regulation of mRNA catabolic process;positive regulation of RIG-I signaling pathway;response to virus","cadherin binding;metal ion binding;RNA binding","cytoplasm;cytosol;nucleus",{"$nulls":3},10,10,10,"16.2","16.2","16.2","101.43",0,"252.23",462810000,43,"1.31043","0.335144","-1.01699","-4.35317","sp|Q7Z2W4|ZCCHV_HUMAN;tr|C9J6P4|C9J6P4_HUMAN;tr|H7C5K1|H7C5K1_HUMAN","sp|Q7Z2W4|ZCCHV_HUMAN;tr|C9J6P4|C9J6P4_HUMAN",1943,"Q7Z2W4","ZCCHV_HUMAN","Zinc finger CCCH-type antiviral protein 1",null,"ZC3HAV1"]
["13.7745",1,"15.8102",1,{"$nulls":3},"intracellular signal transduction","actin binding;ATP binding;GTPase activator activity;motor activity","cytosol;myosin complex",{"$nulls":3},2,2,2,"1.1","1.1","1.1","234.07","0.0020935","2.2284",15242000,1,"0.0331074","0.963562","-1.01785","-0.104083","tr|M0R300|M0R300_HUMAN;tr|M0R0P8|M0R0P8_HUMAN;sp|Q13459|MYO9B_HUMAN","tr|M0R300|M0R300_HUMAN;tr|M0R0P8|M0R0P8_HUMAN;sp|Q13459|MYO9B_HUMAN",1560,"M0R300","M0R300_HUMAN",null,null,"MYO9B"]
["18.4609","18.542","19.6922","19.3476",{"$nulls":3},"response to virus;RNA processing",null,"nucleoplasm",{"$nulls":3},4,4,4,"7.5","7.5","7.5","71.611",0,"9.0463",165700000,16,"1.53918","0.315839","-1.01849","-5.7546","tr|M0R3F1|M0R3F1_HUMAN;tr|A0A0A0MRA5|A0A0A0MRA5_HUMAN;tr|B7Z4B8|B7Z4B8_HUMAN;sp|Q9BUJ2|HNRL1_HUMAN;tr|M0QYM5|M0QYM5_HUMAN;tr|M0QYI8|M0QYI8_HUMAN;tr|M0QYZ0|M0QYZ0_HUMAN","tr|M0R3F1|M0R3F1_HUMAN;tr|A0A0A0MRA5|A0A0A0MRA5_HUMAN;tr|B7Z4B8|B7Z4B8_HUMAN;sp|Q9BUJ2|HNRL1_HUMAN;tr|M0QYM5|M0QYM5_HUMAN;tr|M0QYI8|M0QYI8_HUMAN;tr|M0QYZ0|M0QYZ0_HUMAN",2455,"M0R3F1","M0R3F1_HUMAN",null,null,"HNRNPUL1"]
["17.1649","17.1702","18.4329","17.9396",{"$nulls":3},"'de novo' GDP-L-fucose biosynthetic process;GDP-mannose metabolic process;Notch signaling pathway","GDP-mannose 4,6-dehydratase activity;identical protein binding;NADP+ binding","cytoplasm;cytosol;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Fructose and mannose metabolism;Metabolic pathways",null,null,2,2,2,"8.3","8.3","8.3","41.949",0,"4.5548",47357000,2,"1.26819","0.329317","-1.01877","-4.13005","sp|O60547|GMDS_HUMAN","sp|O60547|GMDS_HUMAN",293,"O60547","GMDS_HUMAN","GDP-mannose 4,6 dehydratase",null,"GMDS"]
["20.7507","19.8033","21.6194","20.9744",{"$nulls":3},"ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;microtubule-based process;platelet degranulation;regulation of G2/M transition of mitotic cell cycle","enzyme binding;GTP binding;GTPase activity;structural constituent of cytoskeleton","cytosol;extracellular exosome;extracellular region;microtubule;microtubule cytoskeleton","Apoptosis;Gap junction;Pathogenic Escherichia coli infection;Phagosome;Tight junction",null,null,19,3,3,52,10,10,"49.924",0,"26.496",411450000,18,"0.663321","0.389764","-1.01985","-1.77957","sp|P68366|TBA4A_HUMAN;tr|C9JDS9|C9JDS9_HUMAN;tr|C9JEV8|C9JEV8_HUMAN;tr|C9JQ00|C9JQ00_HUMAN;tr|C9JJQ8|C9JJQ8_HUMAN;tr|C9JDL2|C9JDL2_HUMAN","sp|P68366|TBA4A_HUMAN",1359,"P68366","TBA4A_HUMAN","Tubulin alpha-4A chain",null,"TUBA4A"]
["18.412","17.6756","19.4358","18.6919",{"$nulls":9},1,1,1,"25.7","25.7","25.7","7.6915","0.00077042","3.0163",16992000,7,"0.719815","0.356421","-1.02005","-1.94898","tr|F5H3X1|F5H3X1_HUMAN;tr|F5H052|F5H052_HUMAN;tr|F5H2X2|F5H2X2_HUMAN;tr|F5H2K4|F5H2K4_HUMAN;tr|F5GWV0|F5GWV0_HUMAN;tr|F5H4P3|F5H4P3_HUMAN;sp|Q6NXE6|ARMC6_HUMAN","tr|F5H3X1|F5H3X1_HUMAN;tr|F5H052|F5H052_HUMAN;tr|F5H2X2|F5H2X2_HUMAN;tr|F5H2K4|F5H2K4_HUMAN;tr|F5GWV0|F5GWV0_HUMAN;tr|F5H4P3|F5H4P3_HUMAN;sp|Q6NXE6|ARMC6_HUMAN",1877,"F5H3X1","F5H3X1_HUMAN",null,null,"ARMC6"]
["16.7456","15.2588","17.256","16.7899",{"$nulls":3},"adherens junction assembly;bicellular tight junction assembly;cell morphogenesis involved in neuron differentiation;mitotic cell cycle;negative regulation of cell-substrate adhesion;negative regulation of microtubule polymerization;post-chaperonin tubulin folding pathway;protein folding;tubulin complex assembly","beta-tubulin binding;chaperone binding;GTPase activator activity","adherens junction;bicellular tight junction;centrosome;cytoplasm;lateral plasma membrane;microtubule",{"$nulls":3},4,4,4,"4.6","4.6","4.6","132.6",0,"11.041",86828000,8,"0.494354","0.518771","-1.02075","-1.31027","sp|Q9BTW9|TBCD_HUMAN;tr|J3KR97|J3KR97_HUMAN;tr|I3L0V3|I3L0V3_HUMAN;tr|I3L4D2|I3L4D2_HUMAN;tr|I3L1S3|I3L1S3_HUMAN;tr|I3L3H4|I3L3H4_HUMAN;tr|I3L131|I3L131_HUMAN;tr|I3L143|I3L143_HUMAN;tr|I3L163|I3L163_HUMAN;tr|I3L500|I3L500_HUMAN;tr|I3L439|I3L439_HUMAN;tr|I3L120|I3L120_HUMAN;tr|A0A0J9YXU4|A0A0J9YXU4_HUMAN;tr|A0A0J9YWI5|A0A0J9YWI5_HUMAN;tr|A0A0J9YVR1|A0A0J9YVR1_HUMAN","sp|Q9BTW9|TBCD_HUMAN;tr|J3KR97|J3KR97_HUMAN;tr|I3L0V3|I3L0V3_HUMAN",2451,"Q9BTW9","TBCD_HUMAN","Tubulin-specific chaperone D",null,"TBCD"]
["14.9203","15.3166","16.3404","15.9468",{"$nulls":3},"intracellular signal transduction;negative regulation of GTPase activity;regulation of small GTPase mediated signal transduction","GTPase activator activity;metal ion binding","cytosol;intracellular;nucleoplasm;plasma membrane",{"$nulls":3},1,1,1,"1.9","1.9","1.9","106.68",0,"9.4323",20890000,7,"1.17487","0.318314","-1.02516","-3.67083","sp|Q9P107|GMIP_HUMAN","sp|Q9P107|GMIP_HUMAN",2777,"Q9P107","GMIP_HUMAN","GEM-interacting protein","MIP","GMIP"]
["19.363","19.2131","20.2302","20.3976",{"$nulls":3},"cell division;kinetochore organization;meiotic chromosome condensation;meiotic chromosome segregation;mitotic chromosome condensation;mitotic sister chromatid segregation","ATP binding;protein heterodimerization activity","condensin complex;cytosol;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},19,19,19,"20.7","20.7","20.7","147.18",0,"116.03",1006500000,65,"1.9289","0.397854","-1.02586","-9.13246","sp|Q9NTJ3|SMC4_HUMAN;tr|E9PD53|E9PD53_HUMAN;tr|C9JR83|C9JR83_HUMAN;tr|C9JVD8|C9JVD8_HUMAN;tr|C9J578|C9J578_HUMAN;tr|C9J9E4|C9J9E4_HUMAN;tr|C9JWF0|C9JWF0_HUMAN;tr|C9IYK2|C9IYK2_HUMAN;tr|C9JJ64|C9JJ64_HUMAN","sp|Q9NTJ3|SMC4_HUMAN;tr|E9PD53|E9PD53_HUMAN",2698,"Q9NTJ3","SMC4_HUMAN","Structural maintenance of chromosomes protein 4","MC protein 4;MC-4","SMC4"]
["16.8711","15.8522","18.0744","16.7023",{"$nulls":3},"innate immune response","RNA binding","cytoplasm",{"$nulls":3},8,8,5,"5.9","5.9","3.8","269.45",0,"47.223",133320000,21,"0.452772","0.551657","-1.02667","-1.20143","sp|Q8IWZ3|ANKH1_HUMAN;tr|E9PDP5|E9PDP5_HUMAN;tr|H0Y785|H0Y785_HUMAN;tr|H0Y472|H0Y472_HUMAN;tr|H0Y4P6|H0Y4P6_HUMAN;tr|H7C0V5|H7C0V5_HUMAN;tr|A0A0A0MQZ8|A0A0A0MQZ8_HUMAN;tr|H0Y7Y3|H0Y7Y3_HUMAN","sp|Q8IWZ3|ANKH1_HUMAN;tr|E9PDP5|E9PDP5_HUMAN;tr|H0Y785|H0Y785_HUMAN;tr|H0Y472|H0Y472_HUMAN;tr|H0Y4P6|H0Y4P6_HUMAN",2018,"Q8IWZ3","ANKH1_HUMAN","Ankyrin repeat and KH domain-containing protein 1",null,"ANKHD1"]
["18.9344","19.1207","19.9663","20.1425",{"$nulls":9},2,2,2,"19.1","19.1","19.1","15.175",0,"42.332",98434000,13,"1.8173","0.381163","-1.02687","-8.01021","tr|F8WBJ6|F8WBJ6_HUMAN;sp|Q9NRX1|PNO1_HUMAN","tr|F8WBJ6|F8WBJ6_HUMAN;sp|Q9NRX1|PNO1_HUMAN",2685,"F8WBJ6","F8WBJ6_HUMAN",null,null,"PNO1"]
["21.1179","20.3394","21.8601","21.6575",{"$nulls":3},"vesicle-mediated transport","cadherin binding","cytoplasm;cytosol;endosome;endosome membrane;Golgi apparatus;lipid droplet;membrane;transport vesicle",{"$nulls":3},10,10,10,"36.4","36.4","36.4","47.074",0,"58.897",718860000,47,"0.904542","0.296444","-1.03013","-2.56125","sp|O60664|PLIN3_HUMAN;tr|K7ERZ3|K7ERZ3_HUMAN;tr|K7EL96|K7EL96_HUMAN;tr|K7ER39|K7ER39_HUMAN","sp|O60664|PLIN3_HUMAN;tr|K7ERZ3|K7ERZ3_HUMAN;tr|K7EL96|K7EL96_HUMAN",297,"O60664","PLIN3_HUMAN","Perilipin-3",null,"PLIN3"]
["16.8459","16.699","18.2406","17.3661",{"$nulls":3},"microtubule-based movement",null,"cytoplasmic dynein complex",{"$nulls":3},6,1,1,"42.4","10.8","10.8","28.404","0.00076511","2.9747",17925000,4,"0.836759","0.314027","-1.03088","-2.32511","tr|E7EV09|E7EV09_HUMAN;tr|E7EQL5|E7EQL5_HUMAN;tr|E7EQU2|E7EQU2_HUMAN;tr|E7ETL8|E7ETL8_HUMAN;tr|E9PGG1|E9PGG1_HUMAN","tr|E7EV09|E7EV09_HUMAN;tr|E7EQL5|E7EQL5_HUMAN;tr|E7EQU2|E7EQU2_HUMAN;tr|E7ETL8|E7ETL8_HUMAN;tr|E9PGG1|E9PGG1_HUMAN",3083,"E7EV09","E7EV09_HUMAN",null,null,"DYNC1I2"]
["14.732","14.1005","15.4795","15.4173",{"$nulls":4},"DNA binding transcription factor activity;RNA binding;zinc ion binding","nucleus",{"$nulls":3},2,2,2,"1.4","1.4","1.4","220.22",0,"6.209",37096000,5,"1.08137","0.309134","-1.03213","-3.25303","sp|Q9P2E3|ZNFX1_HUMAN","sp|Q9P2E3|ZNFX1_HUMAN",2786,"Q9P2E3","ZNFX1_HUMAN","NFX1-type zinc finger-containing protein 1",null,"ZNFX1"]
["13.7457","14.1592","15.3937","14.5755",{"$nulls":3},"actin cytoskeleton organization;activation of JUN kinase activity;activation of MAPK activity;activation of MAPKK activity;activation of protein kinase activity;apoptotic process;axonogenesis;cell migration;cellular response to DNA damage stimulus;dendrite arborization;focal adhesion assembly;mitotic G2 DNA damage checkpoint;nervous system development;positive regulation of dendrite morphogenesis;positive regulation of JNK cascade;positive regulation of neuron projection development;positive regulation of protein autophosphorylation;positive regulation of stress-activated MAPK cascade;protein autophosphorylation;protein targeting to membrane;regulation of actin cytoskeleton organization;regulation of apoptotic process;regulation of cell growth;regulation of cell shape;regulation of mitotic cell cycle;response to stress;stress-activated MAPK cascade","ATP binding;MAP kinase kinase kinase activity;mitogen-activated protein kinase kinase binding;neuropilin binding;protein serine/threonine kinase activity","actin cytoskeleton;axon;axonal growth cone;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;dendritic growth cone;integral component of membrane;intracellular;neuron projection;nucleolus;nucleus;receptor complex","MAPK signaling pathway",null,null,1,1,1,"0.9","0.9","0.9","138.25","0.0010893","2.5297",9789600,1,"0.814868","0.32143","-1.03214","-2.25184","sp|Q9UL54|TAOK2_HUMAN","sp|Q9UL54|TAOK2_HUMAN",2886,"Q9UL54","TAOK2_HUMAN","Serine/threonine-protein kinase TAO2",null,"TAOK2"]
["15.06","15.7477","16.6668","16.2078",{"$nulls":3},"animal organ morphogenesis;ATP-dependent chromatin remodeling;chromatin remodeling;covalent chromatin modification;insulin receptor signaling pathway;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;nervous system development;nucleosome disassembly;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;prostate gland development;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","chromatin binding;DNA binding;protein N-terminus binding;transcription coactivator activity","cytoplasm;nBAF complex;npBAF complex;nuclear chromatin;nucleoplasm;nucleus;protein complex;SWI/SNF complex;XY body","Hepatocellular carcinoma;Thermogenesis",null,null,1,1,1,"1.1","1.1","1.1","122.87",0,"9.3966",38127000,9,"0.887355","0.298539","-1.03347","-2.5","sp|Q92922|SMRC1_HUMAN","sp|Q92922|SMRC1_HUMAN",2204,"Q92922","SMRC1_HUMAN","SWI/SNF complex subunit SMARCC1",null,"SMARCC1"]
["16.1806","17.0305","17.808","17.47",{"$nulls":3},"histone H2B ubiquitination;histone monoubiquitination;negative regulation of cell migration;negative regulation of mRNA polyadenylation;positive regulation of histone H2B ubiquitination;positive regulation of histone methylation;positive regulation of transcription, DNA-templated;protein polyubiquitination;protein ubiquitination;regulation of transcription, DNA-templated;ubiquitin-dependent protein catabolic process","chromatin binding;histone binding;metal ion binding;mRNA 3'-UTR binding;p53 binding;transcription coactivator activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","HULC complex;nucleolus;nucleoplasm;nucleus;ubiquitin ligase complex",{"$nulls":3},3,3,3,"6.4","6.4","6.4","113.66",0,"4.3395",54627000,6,"0.817283","0.323326","-1.03349","-2.25985","sp|Q5VTR2|BRE1A_HUMAN;tr|C9JWJ4|C9JWJ4_HUMAN;tr|C9J0A5|C9J0A5_HUMAN;tr|C9JXC9|C9JXC9_HUMAN","sp|Q5VTR2|BRE1A_HUMAN",1843,"Q5VTR2","BRE1A_HUMAN","E3 ubiquitin-protein ligase BRE1A","BRE1;RE1-A","RNF20"]
["15.3934","15.6406","16.8127","16.292",{"$nulls":4},"actin binding;ATP binding;motor activity","myosin complex",{"$nulls":3},3,3,3,"4.6","4.6","4.6","145.01",0,"10.104",40253000,11,"1.15801","0.313174","-1.03535","-3.59254","tr|A0A0A0MRM8|A0A0A0MRM8_HUMAN;tr|A0A0D9SGC1|A0A0D9SGC1_HUMAN;sp|Q9UM54|MYO6_HUMAN;tr|E7EW20|E7EW20_HUMAN","tr|A0A0A0MRM8|A0A0A0MRM8_HUMAN;tr|A0A0D9SGC1|A0A0D9SGC1_HUMAN;sp|Q9UM54|MYO6_HUMAN;tr|E7EW20|E7EW20_HUMAN",3063,"A0A0A0MRM8","A0A0A0MRM8_HUMAN",null,null,"MYO6"]
["13.7523","13.4246","15.1843","14.0656",{"$nulls":9},1,1,1,"2.2","2.2","2.2","133.85","0.00477","2.0251",14357000,4,"0.6629","0.388588","-1.03652","-1.77833","tr|H0Y3V5|H0Y3V5_HUMAN;sp|Q6YHU6|THADA_HUMAN","tr|H0Y3V5|H0Y3V5_HUMAN;sp|Q6YHU6|THADA_HUMAN",1912,"H0Y3V5","H0Y3V5_HUMAN",null,null,"THADA"]
["19.8368","18.1659","20.2047","19.8725",{"$nulls":3},"carbohydrate metabolic process","phosphotransferase activity, alcohol group as acceptor",null,"Metabolic pathways",null,null,5,5,5,"15.5","15.5","15.5","51.504",0,"43.958",135080000,24,"0.459066","0.544762","-1.03724","-1.21777","tr|A0A0B4J2A0|A0A0B4J2A0_HUMAN;sp|Q9UHJ6|SHPK_HUMAN","tr|A0A0B4J2A0|A0A0B4J2A0_HUMAN;sp|Q9UHJ6|SHPK_HUMAN",3065,"A0A0B4J2A0","A0A0B4J2A0_HUMAN"]
["18.3342","16.9228","18.8813","18.4517",{"$nulls":3},"protein destabilization;regulation of protein complex assembly;regulation of signal transduction",null,"endoplasmic reticulum membrane;integral component of membrane;membrane",{"$nulls":3},3,3,3,"7.6","7.6","7.6","62.974",0,"19.422",82669000,18,"0.530639","0.49684","-1.03801","-1.40707","sp|Q969V3|NCLN_HUMAN;tr|K7EMW4|K7EMW4_HUMAN","sp|Q969V3|NCLN_HUMAN",2224,"Q969V3","NCLN_HUMAN","Nicalin",null,"NCLN"]
["19.2109","19.3095","20.8084","19.789",{"$nulls":3},"cellular sphingolipid homeostasis;ceramide metabolic process",null,"endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},2,2,2,"20.2","20.2","20.2","14.788",0,"12.203",54253000,5,"0.74535","0.343007","-1.0385","-2.02803","tr|J3QRM9|J3QRM9_HUMAN;sp|Q8N138|ORML3_HUMAN;tr|J3KTF9|J3KTF9_HUMAN;tr|F6WST4|F6WST4_HUMAN;tr|A0A0K0K1C5|A0A0K0K1C5_HUMAN;tr|F8VXD5|F8VXD5_HUMAN;sp|Q9P0S3|ORML1_HUMAN;sp|Q53FV1|ORML2_HUMAN","tr|J3QRM9|J3QRM9_HUMAN;sp|Q8N138|ORML3_HUMAN;tr|J3KTF9|J3KTF9_HUMAN;tr|F6WST4|F6WST4_HUMAN;tr|A0A0K0K1C5|A0A0K0K1C5_HUMAN;tr|F8VXD5|F8VXD5_HUMAN;sp|Q9P0S3|ORML1_HUMAN;sp|Q53FV1|ORML2_HUMAN",2032,"J3QRM9","J3QRM9_HUMAN",null,null,"ORMDL3"]
["21.4587","20.7326","22.216","22.0551",{"$nulls":3},"regulation of RNA splicing","RNA binding","cytosol;nuclear speck;nucleus",{"$nulls":3},4,4,4,"31.5","31.5","31.5","15.156",0,"46.827",181220000,24,"0.968087","0.296557","-1.03986","-2.79642","tr|J3QL05|J3QL05_HUMAN;tr|J3KP15|J3KP15_HUMAN;sp|Q01130|SRSF2_HUMAN;sp|Q9BRL6|SRSF8_HUMAN","tr|J3QL05|J3QL05_HUMAN;tr|J3KP15|J3KP15_HUMAN;sp|Q01130|SRSF2_HUMAN",1414,"J3QL05","J3QL05_HUMAN",null,null,"SRSF2"]
["18.5459","18.6272","20.1677","19.0851",{"$nulls":3},"inflammatory response;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of interleukin-8 production;positive regulation of transcription, DNA-templated;regulation of interleukin-6 production;regulation of mitotic cell cycle","protein tyrosine kinase activator activity;SH2 domain binding;SH3 domain binding;signaling adaptor activity","cytoplasm;cytosol;plasma membrane",{"$nulls":3},7,7,7,"16.3","16.3","16.3","91.299",0,"46.286",207550000,32,"0.708908","0.362011","-1.03986","-1.9157","sp|Q8N4X5|AF1L2_HUMAN;tr|F6QUH3|F6QUH3_HUMAN","sp|Q8N4X5|AF1L2_HUMAN;tr|F6QUH3|F6QUH3_HUMAN",2053,"Q8N4X5","AF1L2_HUMAN","Actin filament-associated protein 1-like 2","FAP1-like protein 2","AFAP1L2"]
["14.2544","14.1294","15.6573","14.8077",{"$nulls":3},"DNA damage response, detection of DNA damage;DNA-dependent DNA replication;error-free translesion synthesis;error-prone translesion synthesis;negative regulation of transcription from RNA polymerase II promoter;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of transcription, DNA-templated;telomere maintenance via semi-conservative replication;telomere maintenance via telomerase;transcription, DNA-templated;transcription-coupled nucleotide-excision repair;translesion synthesis","ATP binding;DNA binding;DNA clamp loader activity;double-stranded DNA binding;enzyme activator activity;protein domain specific binding;sequence-specific DNA binding","cytoplasm;DNA replication factor C complex;extracellular exosome;nucleolus;nucleoplasm;nucleus","DNA replication;Mismatch repair;Nucleotide excision repair",null,null,1,1,1,"1.6","1.6","1.6","128.25",0,"4.5272",17900000,8,"0.865474","0.303011","-1.04059","-2.42339","sp|P35251|RFC1_HUMAN","sp|P35251|RFC1_HUMAN",927,"P35251","RFC1_HUMAN","Replication factor C subunit 1",null,"RFC1"]
["17.1486","16.8454","18.617","17.4693",{"$nulls":4},"ATP binding;formate-tetrahydrofolate ligase activity;methylenetetrahydrofolate dehydrogenase (NADP+) activity","mitochondrion",{"$nulls":3},4,4,4,"5.7","5.7","5.7","99.31",0,"7.0983",97866000,22,"0.657524","0.390502","-1.04618","-1.76258","tr|A0A087WVM4|A0A087WVM4_HUMAN;sp|Q6UB35|C1TM_HUMAN;tr|B7ZM99|B7ZM99_HUMAN;tr|Q4VXM0|Q4VXM0_HUMAN;tr|H0Y327|H0Y327_HUMAN","tr|A0A087WVM4|A0A087WVM4_HUMAN;sp|Q6UB35|C1TM_HUMAN;tr|B7ZM99|B7ZM99_HUMAN",1901,"A0A087WVM4","A0A087WVM4_HUMAN",null,null,"MTHFD1L"]
["15.9732","14.5982","16.2847","16.3809",{"$nulls":3},"cilium assembly;early endosome to late endosome transport;endocytic recycling;negative regulation of epithelial cell migration;positive regulation of adherens junction organization;positive regulation of early endosome to late endosome transport;positive regulation of homophilic cell adhesion;positive regulation of Wnt protein secretion;protein transport;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway","protein kinase binding;protein tyrosine phosphatase activity","ciliary basal body;cytoplasm;cytosol;early endosome;endosome;extracellular exosome;nuclear body;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"4.3","4.3","4.3","178.97",0,"5.9999",47824000,15,"0.571805","0.466314","-1.04712","-1.51928","sp|Q9H3S7|PTN23_HUMAN","sp|Q9H3S7|PTN23_HUMAN",2591,"Q9H3S7","PTN23_HUMAN","Tyrosine-protein phosphatase non-receptor type 23",null,"PTPN23"]
["17.4403","16.582","18.6125","17.5051",{"$nulls":3},"mRNA processing","RNA binding","nucleus",{"$nulls":3},2,2,2,"7.3","7.3","7.3","48.023",0,"4.6961",35833000,10,"0.563162","0.469734","-1.04766","-1.49549","tr|G3XAC6|G3XAC6_HUMAN;sp|Q14498|RBM39_HUMAN;tr|H0Y4X3|H0Y4X3_HUMAN","tr|G3XAC6|G3XAC6_HUMAN;sp|Q14498|RBM39_HUMAN;tr|H0Y4X3|H0Y4X3_HUMAN",1625,"G3XAC6","G3XAC6_HUMAN",null,null,"RBM39"]
["18.7011","18.3331","19.8312","19.3006",{"$nulls":3},"interleukin-12-mediated signaling pathway;L-methionine salvage from methylthioadenosine;nucleobase-containing compound metabolic process;purine ribonucleoside salvage","phosphorylase activity;S-methyl-5-thioadenosine phosphorylase activity","cytosol;extracellular exosome;nucleus","Cysteine and methionine metabolism;Metabolic pathways",null,null,4,4,4,"22.3","22.3","22.3","31.236",0,"8.7356",96076000,13,"1.08033","0.307822","-1.04882","-3.2486","sp|Q13126|MTAP_HUMAN;tr|B4DUC8|B4DUC8_HUMAN;tr|J3QSB7|J3QSB7_HUMAN;tr|F8WES2|F8WES2_HUMAN;tr|F2Z2F3|F2Z2F3_HUMAN;tr|J3KRN1|J3KRN1_HUMAN","sp|Q13126|MTAP_HUMAN;tr|B4DUC8|B4DUC8_HUMAN;tr|J3QSB7|J3QSB7_HUMAN;tr|F8WES2|F8WES2_HUMAN;tr|F2Z2F3|F2Z2F3_HUMAN",1523,"Q13126","MTAP_HUMAN","S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}",null,"MTAP"]
["16.309","15.3482","16.9361","16.8199",{"$nulls":3},"cell adhesion;cell surface receptor signaling pathway;cell-cell signaling;G-protein coupled receptor signaling pathway;immune response;inflammatory response;movement of cell or subcellular component;neutrophil degranulation","calcium ion binding;G-protein coupled receptor activity;transmembrane signaling receptor activity","extracellular exosome;focal adhesion;integral component of plasma membrane;membrane;plasma membrane;secretory granule membrane",{"$nulls":3},2,2,2,4,4,4,"91.868",0,"6.2578",31432000,2,"0.789427","0.332638","-1.04937","-2.16841","sp|P48960|CD97_HUMAN","sp|P48960|CD97_HUMAN",1063,"P48960","CD97_HUMAN","CD97 antigen",null,"CD97"]
["20.3125","20.796","21.4108","21.7993",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of type I interferon production;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","cadherin binding;DNA binding;double-stranded RNA binding;protein homodimerization activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytoplasm;cytoskeleton;cytosol;nucleus;plasma membrane",{"$nulls":3},8,8,7,"10.9","10.9","9.4","89.252",0,"303.49",921990000,40,"1.11266","0.311964","-1.0508","-3.38847","sp|Q32MZ4|LRRF1_HUMAN","sp|Q32MZ4|LRRF1_HUMAN",1776,"Q32MZ4","LRRF1_HUMAN","Leucine-rich repeat flightless-interacting protein 1","RR FLII-interacting protein 1","LRRFIP1"]
["18.0251","18.1823","19.538","18.7734",{"$nulls":9},3,3,3,17,17,17,"34.431",0,"13.416",74097000,13,"0.941231","0.297494","-1.05204","-2.69532","tr|E9PH82|E9PH82_HUMAN;sp|Q8NCA5|FA98A_HUMAN;tr|C9J3G8|C9J3G8_HUMAN","tr|E9PH82|E9PH82_HUMAN;sp|Q8NCA5|FA98A_HUMAN",2081,"E9PH82","E9PH82_HUMAN",null,null,"FAM98A"]
["19.9777","17.7163","20.3234","19.4763",{"$nulls":3},"dopamine catabolic process;hydrogen peroxide biosynthetic process;negative regulation of serotonin secretion;neurotransmitter catabolic process;positive regulation of dopamine metabolic process;response to aluminum ion;response to corticosterone;response to drug;response to ethanol;response to lipopolysaccharide;response to selenium ion;response to toxic substance;substantia nigra development","electron transfer activity;flavin adenine dinucleotide binding;primary amine oxidase activity;protein homodimerization activity","extracellular exosome;integral component of membrane;mitochondrial envelope;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion","Alcoholism;Amphetamine addiction;Arginine and proline metabolism;Cocaine addiction;Dopaminergic synapse;Drug metabolism - cytochrome P450;Glycine, serine and threonine metabolism;Histidine metabolism;Metabolic pathways;Phenylalanine metabolism;Serotonergic synapse;Tryptophan metabolism;Tyrosine metabolism",null,null,4,4,4,"13.5","13.5","13.5","58.762",0,"27.265",144870000,17,"0.323154","0.708615","-1.05287","-0.871972","sp|P27338|AOFB_HUMAN;sp|P21397|AOFA_HUMAN","sp|P27338|AOFB_HUMAN",819,"P27338","AOFB_HUMAN","Amine oxidase [flavin-containing] B",null,"MAOB"]
["17.9045","17.7182","19.4576","18.2726",{"$nulls":9},1,1,1,"10.5","10.5","10.5","14.844","0.0010635","2.3536",28886000,2,"0.655598","0.390872","-1.05378","-1.75696","tr|C9J6N5|C9J6N5_HUMAN;tr|C9JQ40|C9JQ40_HUMAN;tr|C9JW51|C9JW51_HUMAN;sp|Q9H098|F107B_HUMAN","tr|C9J6N5|C9J6N5_HUMAN;tr|C9JQ40|C9JQ40_HUMAN;tr|C9JW51|C9JW51_HUMAN;sp|Q9H098|F107B_HUMAN",2552,"C9J6N5","C9J6N5_HUMAN",null,null,"FAM107B"]
["19.1176","17.4277","19.3551","19.3059",{"$nulls":3},"cellular response to interferon-beta;cellular response to oxidative stress;liver regeneration;mitochondrial mRNA catabolic process;mitochondrial mRNA polyadenylation;mitochondrial RNA 3'-end processing;mitochondrial RNA 5'-end processing;mitochondrial RNA catabolic process;mitochondrion morphogenesis;mitotic cell cycle arrest;mRNA catabolic process;negative regulation of growth;nuclear polyadenylation-dependent mRNA catabolic process;positive regulation of miRNA catabolic process;positive regulation of mitochondrial RNA catabolic process;positive regulation of mRNA catabolic process;protein homooligomerization;protein homotrimerization;regulation of cellular respiration;regulation of cellular senescence;response to cAMP;response to growth hormone;RNA catabolic process;RNA import into mitochondrion;RNA polyadenylation;rRNA import into mitochondrion","3'-5'-exoribonuclease activity;miRNA binding;poly(G) binding;poly(U) RNA binding;polyribonucleotide nucleotidyltransferase activity;RNA binding","cytoplasm;cytosol;endoplasmic reticulum membrane;mitochondrial degradosome;mitochondrial intermembrane space;mitochondrion;nucleus;polysomal ribosome","RNA degradation",null,null,4,4,4,"6.8","6.8","6.8","85.95",0,"3.7077",264100000,6,"0.471978","0.532192","-1.05787","-1.25145","sp|Q8TCS8|PNPT1_HUMAN;tr|F8WBI3|F8WBI3_HUMAN;tr|H7BXF6|H7BXF6_HUMAN","sp|Q8TCS8|PNPT1_HUMAN",2116,"Q8TCS8","PNPT1_HUMAN","Polyribonucleotide nucleotidyltransferase 1, mitochondrial",null,"PNPT1"]
["18.8143","16.917","18.0038","19.8455",{"$nulls":3},"asparagine biosynthetic process;cellular amino acid biosynthetic process;cellular response to glucose starvation;cellular response to hormone stimulus;glutamine metabolic process;L-asparagine biosynthetic process;liver development;negative regulation of apoptotic process;PERK-mediated unfolded protein response;positive regulation of mitotic cell cycle;response to amino acid;response to follicle-stimulating hormone;response to light stimulus;response to mechanical stimulus;response to methotrexate;response to toxic substance","asparagine synthase (glutamine-hydrolyzing) activity;ATP binding;cofactor binding;protein homodimerization activity","cytosol","Alanine, aspartate and glutamate metabolism;Biosynthesis of amino acids;Metabolic pathways",null,null,6,6,6,"15.5","15.5","15.5","64.369",0,"8.414",196570000,16,"0.294843","0.734929","-1.05899","-0.800987","sp|P08243|ASNS_HUMAN;tr|F8WEJ5|F8WEJ5_HUMAN;tr|C9J057|C9J057_HUMAN;tr|C9JLN6|C9JLN6_HUMAN;tr|C9JM09|C9JM09_HUMAN;tr|C9JT45|C9JT45_HUMAN","sp|P08243|ASNS_HUMAN;tr|F8WEJ5|F8WEJ5_HUMAN",561,"P08243","ASNS_HUMAN","Asparagine synthetase [glutamine-hydrolyzing]",null,"ASNS"]
["17.9628","17.6505","18.9844","18.7502",{"$nulls":3},"determination of adult lifespan;DNA repair;intrinsic apoptotic signaling pathway;intrinsic apoptotic signaling pathway in response to DNA damage;isotype switching;meiotic mismatch repair;mismatch repair;negative regulation of DNA recombination;positive regulation of helicase activity;positive regulation of isotype switching;response to UV;somatic hypermutation of immunoglobulin genes;somatic recombination of immunoglobulin gene segments;viral process","ATP binding;chromatin binding;damaged DNA binding;DNA-dependent ATPase activity;guanine/thymine mispair binding;methylated histone binding;mismatched DNA binding","cytosol;Golgi apparatus;intracellular membrane-bounded organelle;MutSalpha complex;nuclear chromatin;nucleoplasm","Colorectal cancer;Mismatch repair;Pathways in cancer;Platinum drug resistance",null,null,7,7,7,"7.8","7.8","7.8","152.78",0,"13.675",319090000,30,"1.49162","0.324168","-1.06067","-5.43385","sp|P52701|MSH6_HUMAN;tr|A0A087WWJ1|A0A087WWJ1_HUMAN;tr|F8W7G9|F8W7G9_HUMAN;tr|F8WAX8|F8WAX8_HUMAN;tr|A0A087WYT6|A0A087WYT6_HUMAN","sp|P52701|MSH6_HUMAN;tr|A0A087WWJ1|A0A087WWJ1_HUMAN",1162,"P52701","MSH6_HUMAN","DNA mismatch repair protein Msh6 {ECO:0000250|UniProtKB:P54276}","MSH6 {ECO:0000303|PubMed:8942985}","MSH6"]
["15.1564","15.3571","16.69","15.9449",{"$nulls":4},"enzyme binding",{"$nulls":4},2,2,2,4,4,4,"73.2","0.0010741","2.4008",14461000,5,"0.955612","0.298954","-1.06073","-2.74914","sp|Q9NW82|WDR70_HUMAN;tr|D6RIW8|D6RIW8_HUMAN","sp|Q9NW82|WDR70_HUMAN;tr|D6RIW8|D6RIW8_HUMAN",2725,"Q9NW82","WDR70_HUMAN","WD repeat-containing protein 70",null,"WDR70"]
["17.6907","17.1375","18.6774","18.2759",{"$nulls":3},"adaptive immune response;B cell activation;beta selection;immune response;innate immune response;intracellular signal transduction;negative thymic T cell selection;peptidyl-tyrosine autophosphorylation;peptidyl-tyrosine phosphorylation;positive regulation of alpha-beta T cell differentiation;positive regulation of alpha-beta T cell proliferation;positive regulation of calcium-mediated signaling;positive regulation of T cell differentiation;positive thymic T cell selection;protein phosphorylation;regulation of cell proliferation;T cell activation;T cell aggregation;T cell differentiation;T cell migration;T cell receptor signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding;non-membrane spanning protein tyrosine kinase activity;protein tyrosine kinase activity;receptor binding","cell-cell junction;cytoplasm;cytosol;extrinsic component of cytoplasmic side of plasma membrane;immunological synapse;plasma membrane;T cell receptor complex","Natural killer cell mediated cytotoxicity;NF-kappa B signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Primary immunodeficiency;Ras signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Yersinia infection",null,null,4,4,4,"11.3","11.3","11.3","69.872",0,"7.5158",98055000,15,"1.04692","0.303684","-1.06251","-3.10875","sp|P43403|ZAP70_HUMAN","sp|P43403|ZAP70_HUMAN",1010,"P43403","ZAP70_HUMAN","Tyrosine-protein kinase ZAP-70",null,"ZAP70"]
["17.7663","18.4374","19.2712","19.0588",{"$nulls":4},"cadherin binding;structural molecule activity","basement membrane;extracellular exosome",{"$nulls":3},4,4,4,"11.6","11.6","11.6","57.13",0,"14.214",98730000,15,"1.0253","0.298251","-1.06314","-3.02068","sp|O00515|LAD1_HUMAN;tr|E9PDI4|E9PDI4_HUMAN;tr|A0A0J9YVY2|A0A0J9YVY2_HUMAN;tr|A0A0J9YYF6|A0A0J9YYF6_HUMAN;tr|A0A0J9YW63|A0A0J9YW63_HUMAN","sp|O00515|LAD1_HUMAN;tr|E9PDI4|E9PDI4_HUMAN;tr|A0A0J9YVY2|A0A0J9YVY2_HUMAN;tr|A0A0J9YYF6|A0A0J9YYF6_HUMAN;tr|A0A0J9YW63|A0A0J9YW63_HUMAN",150,"O00515","LAD1_HUMAN","Ladinin-1","ad-1","LAD1"]
["15.2398","17.1819","18.2487","16.3138",{"$nulls":3},"apoptotic process;cellular response to virus;mRNA processing;negative regulation of GTPase activity;negative regulation of phosphatase activity;positive regulation by host of viral transcription;positive regulation of apoptotic process;positive regulation of transcription from RNA polymerase II promoter;regulation of RNA splicing;RNA splicing;rRNA processing","RNA binding;RNA polymerase II transcription coactivator activity","cytosol;euchromatin;granular component;heterochromatin;nucleolus;nucleoplasm;nucleus;preribosome, large subunit precursor;preribosome, small subunit precursor",{"$nulls":3},2,2,2,"2.8","2.8","2.8","84.427",0,"7.0067",56297000,3,"0.286839","0.745203","-1.07042","-0.780919","sp|Q14684|RRP1B_HUMAN","sp|Q14684|RRP1B_HUMAN",1638,"Q14684","RRP1B_HUMAN","Ribosomal RNA processing protein 1 homolog B",null,"RRP1B"]
["15.4707","15.3312","16.7997","16.1452",{"$nulls":3},"maintenance of epithelial cell apical/basal polarity;nervous system development;signal transduction",null,"basolateral plasma membrane;cytoplasm;PML body",{"$nulls":3},3,3,3,10,10,10,"73.449",0,"6.5402",27727000,3,"1.06933","0.30423","-1.07146","-3.20205","sp|O75427|LRCH4_HUMAN;tr|C9JYK0|C9JYK0_HUMAN","sp|O75427|LRCH4_HUMAN",342,"O75427","LRCH4_HUMAN","Leucine-rich repeat and calponin homology domain-containing protein 4",null,"LRCH4"]
["19.9993","20.3065","21.164","21.2864",{"$nulls":9},2,2,2,"34.6","34.6","34.6","9.2555",0,"5.6918",76960000,14,"1.63913","0.326495","-1.07227","-6.48611","tr|F5GYQ2|F5GYQ2_HUMAN;tr|F5GX77|F5GX77_HUMAN;sp|Q9UI30|TR112_HUMAN","tr|F5GYQ2|F5GYQ2_HUMAN;tr|F5GX77|F5GX77_HUMAN;sp|Q9UI30|TR112_HUMAN",2847,"F5GYQ2","F5GYQ2_HUMAN",null,null,"TRMT112"]
["19.1533","19.1352","20.4184","20.0181",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity",{"$nulls":4},5,5,5,"17.7","17.7","17.7","45.31",0,"26.275",180170000,12,"1.48031","0.3279","-1.07405","-5.35997","tr|E7EU96|E7EU96_HUMAN;sp|P68400|CSK21_HUMAN;tr|Q5U5J2|Q5U5J2_HUMAN;sp|Q8NEV1|CSK23_HUMAN;tr|V9GYA2|V9GYA2_HUMAN;tr|V9GY80|V9GY80_HUMAN","tr|E7EU96|E7EU96_HUMAN;sp|P68400|CSK21_HUMAN;tr|Q5U5J2|Q5U5J2_HUMAN;sp|Q8NEV1|CSK23_HUMAN",1361,"E7EU96","E7EU96_HUMAN",null,null,"CSNK2A1"]
["12.6355","12.3699","14.4404","12.7133",{"$nulls":3},"animal organ development;apoptotic process;establishment of mitotic spindle orientation;Golgi organization;negative regulation of extrinsic apoptotic signaling pathway;positive regulation of aggrephagy;positive regulation of apoptotic process;positive regulation of autophagy of mitochondrion;positive regulation of cilium assembly;positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;positive regulation of lipophagy;protein destabilization;regulation of phosphoprotein phosphatase activity;retrograde vesicle-mediated transport, Golgi to ER;vesicle transport along microtubule;vocal learning","beta-tubulin binding;dynactin binding;dynein intermediate chain binding;heat shock protein binding;identical protein binding;ion channel binding;kinase binding;lipid transporter activity;p53 binding;profilin binding;transcription factor binding","autophagosome;axon;centriole;cytoplasm;cytoplasmic vesicle membrane;cytosol;dendrite;endoplasmic reticulum;Golgi apparatus;inclusion body;late endosome;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex","Huntington disease",null,null,2,2,2,1,1,1,"347.6",0,"3.8016",18504000,7,"0.46354","0.539025","-1.07416","-1.22942","sp|P42858|HD_HUMAN","sp|P42858|HD_HUMAN",1000,"P42858","HD_HUMAN","Huntingtin",null,"HTT"]
["19.8549","19.6454","21.0029","20.6502",{"$nulls":3},"negative regulation of ATPase activity;ossification;protein import into mitochondrial matrix",null,"extrinsic component of mitochondrial inner membrane;mitochondrial matrix;presequence translocase-associated import motor;protein complex",{"$nulls":3},2,2,2,"24.8","24.8","24.8","13.825",0,"33.96",66692000,8,"1.46275","0.323012","-1.07642","-5.24713","sp|Q9Y3D7|TIM16_HUMAN;tr|I3L1U7|I3L1U7_HUMAN;tr|I3L0X9|I3L0X9_HUMAN;tr|I3L3T0|I3L3T0_HUMAN;tr|A0A0A6YYL4|A0A0A6YYL4_HUMAN","sp|Q9Y3D7|TIM16_HUMAN;tr|I3L1U7|I3L1U7_HUMAN;tr|I3L0X9|I3L0X9_HUMAN;tr|I3L3T0|I3L3T0_HUMAN;tr|A0A0A6YYL4|A0A0A6YYL4_HUMAN",2985,"Q9Y3D7","TIM16_HUMAN","Mitochondrial import inner membrane translocase subunit TIM16",null,"PAM16"]
["16.3363","14.7643","17.0847","16.169",{"$nulls":3},"axon guidance;brain development;cell proliferation;cellular response to glucose stimulus;cellular response to insulin stimulus;glucose metabolic process;insulin receptor signaling pathway;interleukin-7-mediated signaling pathway;lipid homeostasis;mammary gland development;MAPK cascade;negative regulation of B cell apoptotic process;negative regulation of kinase activity;negative regulation of plasma membrane long-chain fatty acid transport;phosphatidylinositol-mediated signaling;positive regulation of B cell proliferation;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of fatty acid beta-oxidation;positive regulation of glucose import;positive regulation of glucose metabolic process;positive regulation of glycogen biosynthetic process;positive regulation of insulin secretion;positive regulation of mesenchymal cell proliferation;positive regulation of protein kinase B signaling;regulation of lipid metabolic process;response to glucose;signal transduction","14-3-3 protein binding;1-phosphatidylinositol-3-kinase activity;insulin receptor binding;phosphatidylinositol 3-kinase binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;protein domain specific binding;protein kinase binding;protein phosphatase binding;Ras guanyl-nucleotide exchange factor activity;signal transducer activity","cytosol;plasma membrane;protein complex","Adipocytokine signaling pathway;AMPK signaling pathway;Autophagy - animal;cGMP-PKG signaling pathway;FoxO signaling pathway;Insulin resistance;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;MicroRNAs in cancer;Non-alcoholic fatty liver disease (NAFLD);Regulation of lipolysis in adipocytes;Type II diabetes mellitus",null,null,2,2,2,"2.5","2.5","2.5","137.33",0,"13.149",21397000,5,"0.445843","0.555543","-1.07655","-1.18348","sp|Q9Y4H2|IRS2_HUMAN","sp|Q9Y4H2|IRS2_HUMAN",3000,"Q9Y4H2","IRS2_HUMAN","Insulin receptor substrate 2","RS-2","IRS2"]
["23.2007","22.5904","24.1152","23.8342",{"$nulls":3},"embryonic forelimb morphogenesis;epidermis development;positive regulation of collateral sprouting;regulation of retinoic acid receptor signaling pathway;regulation of transcription, DNA-templated;retinoic acid metabolic process;signal transduction","retinal binding;retinoic acid binding;retinoid binding;retinol binding","cytosol;endoplasmic reticulum;extracellular exosome;nucleoplasm",{"$nulls":3},6,6,6,"35.5","35.5","35.5","15.693",0,"36.224",1077100000,36,"1.07183","0.304","-1.07919","-3.2126","sp|P29373|RABP2_HUMAN;tr|Q5SYZ4|Q5SYZ4_HUMAN;tr|B5MCB5|B5MCB5_HUMAN;sp|P29762|RABP1_HUMAN","sp|P29373|RABP2_HUMAN;tr|Q5SYZ4|Q5SYZ4_HUMAN",848,"P29373","RABP2_HUMAN","Cellular retinoic acid-binding protein 2",null,"CRABP2"]
["19.6854","19.8986","21.2205","20.5273",{"$nulls":9},4,4,4,"22.4","22.4","22.4","25.829",0,"12.755",144200000,14,"1.01597","0.293681","-1.08187","-2.98325","tr|E9PBT8|E9PBT8_HUMAN;sp|Q8NBJ7|SUMF2_HUMAN;tr|J3KQJ1|J3KQJ1_HUMAN;tr|J3QT17|J3QT17_HUMAN;tr|C9JL30|C9JL30_HUMAN;tr|A8MXB9|A8MXB9_HUMAN;tr|C9J660|C9J660_HUMAN;tr|F8WEX5|F8WEX5_HUMAN;tr|E9PG02|E9PG02_HUMAN;tr|H7C3B2|H7C3B2_HUMAN;tr|F8WA42|F8WA42_HUMAN;tr|F8WEV7|F8WEV7_HUMAN;tr|F8WES7|F8WES7_HUMAN","tr|E9PBT8|E9PBT8_HUMAN;sp|Q8NBJ7|SUMF2_HUMAN;tr|J3KQJ1|J3KQJ1_HUMAN;tr|J3QT17|J3QT17_HUMAN;tr|C9JL30|C9JL30_HUMAN;tr|A8MXB9|A8MXB9_HUMAN;tr|C9J660|C9J660_HUMAN;tr|F8WEX5|F8WEX5_HUMAN;tr|E9PG02|E9PG02_HUMAN;tr|H7C3B2|H7C3B2_HUMAN;tr|F8WA42|F8WA42_HUMAN",2072,"E9PBT8","E9PBT8_HUMAN",null,null,"SUMF2"]
["18.1445","17.843","19.4168","18.7369",{"$nulls":4},"metal ion binding;metalloendopeptidase activity",{"$nulls":4},4,4,4,"10.3","10.3","10.3","68.867",0,"7.5763",115280000,9,"0.998136","0.295529","-1.08307","-2.91266","tr|E9PCB6|E9PCB6_HUMAN;sp|Q9BYT8|NEUL_HUMAN;tr|H0YAK4|H0YAK4_HUMAN;tr|H0YAF7|H0YAF7_HUMAN","tr|E9PCB6|E9PCB6_HUMAN;sp|Q9BYT8|NEUL_HUMAN;tr|H0YAK4|H0YAK4_HUMAN",2512,"E9PCB6","E9PCB6_HUMAN",null,null,"NLN"]
["17.2832","17.0119","18.8836","17.5809",{"$nulls":3},"cell division;cellular response to heat;cellular response to interferon-alpha;intracellular transport of virus;MAPK import into nucleus;mitotic nuclear envelope disassembly;mitotic spindle assembly checkpoint;mRNA export from nucleus;mRNA export from nucleus in response to heat stress;negative regulation of RNA export from nucleus;negative regulation of transcription from RNA polymerase II promoter;negative regulation of translational initiation;nuclear pore organization;positive regulation of heterochromatin assembly;positive regulation of intracellular protein transport;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of protein export from nucleus;positive regulation of protein import into nucleus;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of mitotic sister chromatid separation;regulation of mitotic spindle assembly;response to epidermal growth factor;RNA export from nucleus;RNA import into nucleus;tRNA export from nucleus;viral process;viral transcription","chromatin binding;dynein complex binding;heat shock protein binding;mitogen-activated protein kinase binding;mRNA binding;nucleocytoplasmic transporter activity;protein homodimerization activity;RNA binding;tubulin binding","cytoplasm;cytoplasmic dynein complex;extrinsic component of membrane;host cell;kinetochore;mitotic spindle;nuclear envelope;nuclear inclusion body;nuclear membrane;nuclear periphery;nuclear pore;nuclear pore nuclear basket;nucleoplasm;nucleus","Pathways in cancer;RNA transport;Thyroid cancer",null,null,8,8,8,"5.1","5.1","5.1","267.29",0,"36.713",269140000,41,"0.611518","0.427071","-1.08466","-1.63026","sp|P12270|TPR_HUMAN","sp|P12270|TPR_HUMAN",644,"P12270","TPR_HUMAN","Nucleoprotein TPR",null,"TPR"]
["16.6393","16.3676","18.1018","17.0792",{"$nulls":3},"DNA damage response, detection of DNA damage;DNA ligation;DNA synthesis involved in DNA repair;mismatch repair;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;telomere maintenance;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","DNA-directed DNA polymerase activity","cytoplasm;delta DNA polymerase complex;nucleoplasm;nucleus","Base excision repair;DNA replication;Homologous recombination;Mismatch repair;Nucleotide excision repair",null,null,2,2,2,"4.9","4.9","4.9","51.4","0.001407","2.3099",55408000,4,"0.753863","0.339237","-1.08704","-2.05475","sp|Q15054|DPOD3_HUMAN","sp|Q15054|DPOD3_HUMAN",1668,"Q15054","DPOD3_HUMAN","DNA polymerase delta subunit 3",null,"POLD3"]
["18.3754","17.4625","19.1649","18.8514",{"$nulls":3},"mRNA cis splicing, via spliceosome;mRNA splicing, via spliceosome;positive regulation of protein targeting to mitochondrion;regulation of autophagy of mitochondrion;rRNA processing","RNA binding;single-stranded DNA binding;WW domain binding","cytosol;intracellular membrane-bounded organelle;nucleoplasm;nucleus;spliceosomal complex","Spliceosome",null,null,4,4,4,"8.4","8.4","8.4","69.997",0,"16.597",116530000,13,"0.81643","0.32167","-1.08922","-2.25702","sp|Q9Y2W2|WBP11_HUMAN;tr|F5H5G4|F5H5G4_HUMAN","sp|Q9Y2W2|WBP11_HUMAN",2961,"Q9Y2W2","WBP11_HUMAN","WW domain-binding protein 11","BP-11","WBP11"]
["19.6085","19.6953","20.7734","20.7091",{"$nulls":3},"response to drug;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane, translocation","7S RNA binding;RNA binding;signal recognition particle binding;TPR domain binding","cytosol;endoplasmic reticulum;signal recognition particle;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,7,7,7,"15.2","15.2","15.2","74.605",0,"69.83",438500000,28,"2.61096","0.55619","-1.08933","-20.1689","sp|O76094|SRP72_HUMAN;tr|R4GNC1|R4GNC1_HUMAN;tr|D6RDY6|D6RDY6_HUMAN","sp|O76094|SRP72_HUMAN",388,"O76094","SRP72_HUMAN","Signal recognition particle subunit SRP72","RP72","SRP72"]
["17.4561","17.4309","18.6675","18.4057",{"$nulls":3},"cellular response to lithium ion;DNA ligation involved in DNA repair;DNA recombination;double-strand break repair;double-strand break repair via nonhomologous end joining;establishment of integrated proviral latency;positive regulation of ligase activity;response to X-ray","identical protein binding;protein C-terminus binding","cytosol;DNA ligase IV complex;DNA-dependent protein kinase-DNA ligase 4 complex;nonhomologous end joining complex;nucleoplasm;nucleus","Non-homologous end-joining",null,null,3,3,3,11,11,11,"38.286",0,"15.153",41022000,10,"1.84876","0.383824","-1.09311","-8.31239","sp|Q13426|XRCC4_HUMAN","sp|Q13426|XRCC4_HUMAN",1552,"Q13426","XRCC4_HUMAN","DNA repair protein XRCC4",null,"XRCC4"]
["16.8831","16.8279","17.9978","17.9087",{"$nulls":5},"acrosomal vesicle",{"$nulls":3},2,2,2,"1.3","1.3","1.3","187.02","0.0010737","2.3967",141510000,3,"2.6434","0.584678","-1.09773","-20.9391","sp|Q9ULL0|K1210_HUMAN","sp|Q9ULL0|K1210_HUMAN",2894,"Q9ULL0","K1210_HUMAN","Acrosomal protein KIAA1210 {ECO:0000305}"]
["17.4356","17.2439","18.6351","18.2407",{"$nulls":9},1,1,1,"6.3","6.3","6.3","30.983","0.00039698","3.3176",22246000,7,"1.42438","0.332571","-1.09815","-5.00786","tr|E9PMR3|E9PMR3_HUMAN;sp|Q9BUR4|WAP53_HUMAN","tr|E9PMR3|E9PMR3_HUMAN;sp|Q9BUR4|WAP53_HUMAN",2461,"E9PMR3","E9PMR3_HUMAN",null,null,"WRAP53"]
["14.0844","12.4806","15.0525","13.7128",{"$nulls":3},"intracellular signal transduction","ATP binding;protein serine/threonine kinase activity","intracellular",{"$nulls":3},4,4,4,"3.3","3.3","3.3","187.3",0,"10.755",36029000,7,"0.394911","0.624556","-1.10019","-1.05296","tr|H7BYJ3|H7BYJ3_HUMAN;sp|O14578|CTRO_HUMAN","tr|H7BYJ3|H7BYJ3_HUMAN;sp|O14578|CTRO_HUMAN",161,"H7BYJ3","H7BYJ3_HUMAN",null,null,"CIT"]
["21.0797","20.1619","21.8438","21.5997",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;membrane;nucleolus","Ribosome",null,null,2,2,2,"17.1","17.1","17.1","12.254","0.0010807","2.4598",90098000,5,"0.834795","0.314104","-1.10096","-2.31848","sp|Q9Y3U8|RL36_HUMAN;tr|J3QSB5|J3QSB5_HUMAN","sp|Q9Y3U8|RL36_HUMAN;tr|J3QSB5|J3QSB5_HUMAN",2989,"Q9Y3U8","RL36_HUMAN","60S ribosomal protein L36",null,"RPL36"]
["19.0492","19.1751","20.4741","19.9542",{"$nulls":3},"heart development;positive regulation of axon extension;positive regulation of dendritic spine development;positive regulation of translation","translation initiation factor activity","axon",{"$nulls":3},12,12,12,"18.1","18.1","18.1","102.33",0,"90.634",590860000,44,"1.26629","0.327321","-1.10201","-4.12024","tr|D3DQV9|D3DQV9_HUMAN;sp|P78344|IF4G2_HUMAN;tr|H0Y3P2|H0Y3P2_HUMAN;tr|H0YCH5|H0YCH5_HUMAN;tr|H0YEC5|H0YEC5_HUMAN;tr|H0YD77|H0YD77_HUMAN;tr|E9PKF8|E9PKF8_HUMAN;tr|H0YD99|H0YD99_HUMAN;tr|H0YEN8|H0YEN8_HUMAN;tr|H0YDC0|H0YDC0_HUMAN;tr|H0YCF8|H0YCF8_HUMAN;tr|H0YE22|H0YE22_HUMAN","tr|D3DQV9|D3DQV9_HUMAN;sp|P78344|IF4G2_HUMAN;tr|H0Y3P2|H0Y3P2_HUMAN;tr|H0YCH5|H0YCH5_HUMAN",1366,"D3DQV9","D3DQV9_HUMAN"]
["19.1278","19.0836","20.2736","20.1474",{"$nulls":3},"apoptotic process;blood circulation;cellular response to insulin stimulus;cellular response to interferon-beta;cellular response to interferon-gamma;cellular response to organic cyclic compound;defense response to virus;interferon-gamma-mediated signaling pathway;interleukin-12-mediated signaling pathway;JAK-STAT cascade;macrophage derived foam cell differentiation;metanephric mesenchymal cell differentiation;metanephric mesenchymal cell proliferation involved in metanephros development;negative regulation by virus of viral protein levels in host cell;negative regulation of angiogenesis;negative regulation of endothelial cell proliferation;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;negative regulation of metanephric nephron tubule epithelial cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of defense response to virus by host;positive regulation of erythrocyte differentiation;positive regulation of interferon-alpha production;positive regulation of mesenchymal cell proliferation;positive regulation of nitric-oxide synthase biosynthetic process;positive regulation of smooth muscle cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of apoptotic process;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway;renal tubule development;response to cAMP;response to cytokine;response to drug;response to hydrogen peroxide;response to interferon-beta;response to mechanical stimulus;response to nutrient;response to peptide hormone;transcription, DNA-templated;tumor necrosis factor-mediated signaling pathway;type I interferon signaling pathway;viral process","cadherin binding;CCR5 chemokine receptor binding;core promoter binding;DNA binding transcription factor activity;double-stranded DNA binding;enzyme binding;histone acetyltransferase binding;histone binding;identical protein binding;nuclear hormone receptor binding;promoter-specific chromatin binding;protein homodimerization activity;protein phosphatase 2A binding;repressing transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;signal transducer activity;transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;tumor necrosis factor receptor binding;ubiquitin-like protein ligase binding","axon;cytoplasm;cytosol;dendrite;nuclear chromatin;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex","AGE-RAGE signaling pathway in diabetic complications;Chemokine signaling pathway;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human papillomavirus infection;Inflammatory bowel disease (IBD);Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Prolactin signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis",null,null,9,9,9,"16.4","16.4","16.4","87.334",0,"29.029",410810000,37,"2.43893","0.500556","-1.10479","-16.5301","sp|P42224|STAT1_HUMAN;tr|J3KPM9|J3KPM9_HUMAN;tr|E7EPD2|E7EPD2_HUMAN;tr|D2KFR9|D2KFR9_HUMAN;tr|H7BZ88|H7BZ88_HUMAN;tr|H7BZB5|H7BZB5_HUMAN;tr|E7ENM1|E7ENM1_HUMAN","sp|P42224|STAT1_HUMAN;tr|J3KPM9|J3KPM9_HUMAN",992,"P42224","STAT1_HUMAN","Signal transducer and activator of transcription 1-alpha/beta",null,"STAT1"]
["18.1054","17.9685","19.3366","18.949",{"$nulls":3},"ATP-dependent chromatin remodeling;chromatin assembly or disassembly;DNA methylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;regulation of fibroblast migration;regulation of signal transduction by p53 class mediator","chromatin binding;DNA binding transcription factor activity;histone deacetylase activity;histone deacetylase binding;RNA polymerase II repressing transcription factor binding;RNA polymerase II transcription factor binding;sequence-specific DNA binding;transcription factor activity, transcription factor binding;transcription regulatory region DNA binding;zinc ion binding","histone deacetylase complex;membrane;nuclear chromatin;nucleoplasm;NuRD complex;protein complex;transcription factor complex",{"$nulls":3},4,4,4,"8.8","8.8","8.8","75.022",0,"27.245",209390000,25,"1.4834","0.325088","-1.10585","-5.38009","sp|O94776|MTA2_HUMAN","sp|O94776|MTA2_HUMAN",391,"O94776","MTA2_HUMAN","Metastasis-associated protein MTA2",null,"MTA2"]
["20.3983","20.5864","21.824","21.3757",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","cadherin binding;RNA binding","cytoplasm;membrane",{"$nulls":3},7,7,7,"12.9","12.9","12.9","48.043",0,"16.627",633430000,27,"1.34716","0.336646","-1.1075","-4.55554","sp|Q7L1Q6|BZW1_HUMAN;tr|C9IZ80|C9IZ80_HUMAN;tr|C9JFN4|C9JFN4_HUMAN;tr|C9J188|C9J188_HUMAN;tr|C9JWF5|C9JWF5_HUMAN;tr|H0Y503|H0Y503_HUMAN","sp|Q7L1Q6|BZW1_HUMAN;tr|C9IZ80|C9IZ80_HUMAN;tr|C9JFN4|C9JFN4_HUMAN",1930,"Q7L1Q6","BZW1_HUMAN","Basic leucine zipper and W2 domain-containing protein 1",null,"BZW1"]
["16.4854","18.199","18.1439","18.7564",{"$nulls":3},"activation of GTPase activity;intracellular protein transport;regulation of vesicle fusion","calcium ion binding;GTPase activator activity;Rab GTPase binding","endomembrane system;integral component of membrane;intracellular",{"$nulls":3},3,3,3,3,3,3,"140.52",0,"8.0329",124710000,9,"0.45903","0.544369","-1.10796","-1.21768","sp|Q66K14|TBC9B_HUMAN;tr|G3V133|G3V133_HUMAN","sp|Q66K14|TBC9B_HUMAN",1855,"Q66K14","TBC9B_HUMAN","TBC1 domain family member 9B",null,"TBC1D9B"]
["17.2164","16.8432","18.6537","17.6239",{"$nulls":4},"tRNA (adenine-N1-)-methyltransferase activity","tRNA (m1A) methyltransferase complex",{"$nulls":3},1,1,1,"9.4","9.4","9.4","20.421","0.0003861","3.0646",15517000,1,"0.744348","0.343235","-1.109","-2.0249","tr|H0Y2Q1|H0Y2Q1_HUMAN;sp|Q96FX7|TRM61_HUMAN","tr|H0Y2Q1|H0Y2Q1_HUMAN;sp|Q96FX7|TRM61_HUMAN",2270,"H0Y2Q1","H0Y2Q1_HUMAN",null,null,"TRMT61A"]
["14.5429","14.4306","15.9026","15.2898",{"$nulls":4},"carbon-nitrogen ligase activity, with glutamine as amido-N-donor",{"$nulls":4},1,1,1,"4.5","4.5","4.5","39.539","0.0027768","2.1842",8204200,2,"1.15129","0.308259","-1.1094","-3.56172","tr|D6RDU9|D6RDU9_HUMAN;tr|D6REA0|D6REA0_HUMAN;sp|O75879|GATB_HUMAN","tr|D6RDU9|D6RDU9_HUMAN;tr|D6REA0|D6REA0_HUMAN;sp|O75879|GATB_HUMAN",372,"D6RDU9","D6RDU9_HUMAN",null,null,"GATB"]
["16.2526","16.8858","17.8736","17.4837",{"$nulls":3},"protein dephosphorylation;protein phosphorylation;signal transduction","protein phosphatase regulator activity","protein phosphatase 4 complex",{"$nulls":3},3,3,3,"3.2","3.2","3.2",107,0,"7.5717",73983000,7,"1.01607","0.294762","-1.10945","-2.98367","sp|Q8TF05|PP4R1_HUMAN;tr|J3QL26|J3QL26_HUMAN;tr|J3KSB0|J3KSB0_HUMAN;tr|J3QLA6|J3QLA6_HUMAN;tr|J3QQV0|J3QQV0_HUMAN;tr|J3KRU1|J3KRU1_HUMAN","sp|Q8TF05|PP4R1_HUMAN;tr|J3QL26|J3QL26_HUMAN;tr|J3KSB0|J3KSB0_HUMAN;tr|J3QLA6|J3QLA6_HUMAN;tr|J3QQV0|J3QQV0_HUMAN",2131,"Q8TF05","PP4R1_HUMAN","Serine/threonine-protein phosphatase 4 regulatory subunit 1",null,"PPP4R1"]
["15.4959","15.1647","16.8301","16.0537",{"$nulls":3},"intracellular distribution of mitochondria;mitochondrion organization","mRNA binding","cytoplasm",{"$nulls":3},9,2,1,"12.3","3.3","1.1","146.67","0.0010799","2.4501",57526000,10,"0.924562","0.294108","-1.11162","-2.63384","sp|O75153|CLU_HUMAN;tr|I3L318|I3L318_HUMAN","sp|O75153|CLU_HUMAN",325,"O75153","CLU_HUMAN","Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013}",null,"CLUH"]
["18.0733","18.8555","19.8538","19.3017",{"$nulls":3},"cell cycle arrest;cellular respiration;mitochondrial mRNA processing;mRNA metabolic process;positive regulation of cell proliferation;regulation of mitochondrial mRNA stability","protein kinase activity;RNA binding","mitochondrial matrix;mitochondrion",{"$nulls":3},3,3,3,"5.2","5.2","5.2","70.737",0,"19.516",213700000,16,"0.836946","0.314446","-1.11333","-2.32574","sp|Q969Z0|TBRG4_HUMAN;tr|C9J7P5|C9J7P5_HUMAN;tr|C9IZN7|C9IZN7_HUMAN;tr|C9J5A2|C9J5A2_HUMAN;tr|C9J347|C9J347_HUMAN","sp|Q969Z0|TBRG4_HUMAN;tr|C9J7P5|C9J7P5_HUMAN;tr|C9IZN7|C9IZN7_HUMAN",2226,"Q969Z0","FAKD4_HUMAN","FAST kinase domain-containing protein 4 {ECO:0000303|PubMed:20869947}",null,"TBRG4"]
["14.8493","14.5656","16.2396","15.4053",{"$nulls":5},"cell junction;nucleoplasm;plasma membrane",{"$nulls":3},1,1,1,"3.4","3.4","3.4","68.258","0.0072944","1.8136",17345000,2,"0.896005","0.298182","-1.11501","-2.5307","tr|H0YCG0|H0YCG0_HUMAN;tr|A0A0G2JMS7|A0A0G2JMS7_HUMAN;tr|A0A0G2JNZ2|A0A0G2JNZ2_HUMAN;sp|Q14160|SCRIB_HUMAN;tr|A0A0G2JPP5|A0A0G2JPP5_HUMAN","tr|H0YCG0|H0YCG0_HUMAN;tr|A0A0G2JMS7|A0A0G2JMS7_HUMAN;tr|A0A0G2JNZ2|A0A0G2JNZ2_HUMAN;sp|Q14160|SCRIB_HUMAN;tr|A0A0G2JPP5|A0A0G2JPP5_HUMAN",1606,"H0YCG0","H0YCG0_HUMAN",null,null,"SCRIB"]
["17.4597","18.3206","19.28","18.7351",{"$nulls":3},"4-hydroxyproline catabolic process;glyoxylate metabolic process;proline catabolic process;proline catabolic process to glutamate;proline metabolic process","1-pyrroline-5-carboxylate dehydrogenase activity;aldehyde dehydrogenase (NAD) activity;electron transfer activity;identical protein binding","mitochondrial matrix","Alanine, aspartate and glutamate metabolism;Arginine and proline metabolism;Metabolic pathways",null,null,4,4,4,"10.3","10.3","10.3","61.719",0,"10.048",101780000,13,"0.797174","0.331316","-1.11741","-2.19363","sp|P30038|AL4A1_HUMAN;tr|Q5TF55|Q5TF55_HUMAN","sp|P30038|AL4A1_HUMAN",853,"P30038","AL4A1_HUMAN","Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","5C dehydrogenase","ALDH4A1"]
["22.2349","21.4242","22.6052","23.2893",{"$nulls":3},"ATP-dependent chromatin remodeling;cell junction assembly;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component;negative regulation of protein binding;platelet aggregation;positive regulation of gene expression, epigenetic;postsynaptic actin cytoskeleton organization;protein deubiquitination;retina homeostasis;substantia nigra development;vascular endothelial growth factor receptor signaling pathway","ATP binding;identical protein binding;kinesin binding;nitric-oxide synthase binding;structural constituent of cytoskeleton;structural constituent of postsynaptic actin cytoskeleton;Tat protein binding","actin cytoskeleton;blood microparticle;cortical cytoskeleton;cytoplasm;cytoplasmic ribonucleoprotein granule;cytoskeleton;cytosol;dense body;extracellular exosome;extracellular space;focal adhesion;intracellular ribonucleoprotein complex;membrane;myelin sheath;NuA4 histone acetyltransferase complex;nuclear chromatin;nucleoplasm;nucleus;plasma membrane;protein complex;vesicle","Adherens junction;Apoptosis;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Dilated cardiomyopathy (DCM);Fluid shear stress and atherosclerosis;Focal adhesion;Gastric acid secretion;Hepatocellular carcinoma;Hippo signaling pathway;Hypertrophic cardiomyopathy (HCM);Influenza A;Leukocyte transendothelial migration;Oxytocin signaling pathway;Pathogenic Escherichia coli infection;Phagosome;Platelet activation;Proteoglycans in cancer;Rap1 signaling pathway;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis;Thermogenesis;Thyroid hormone signaling pathway;Tight junction;Vibrio cholerae infection;Viral myocarditis;Yersinia infection",null,null,23,1,1,"73.9","4.5","4.5","41.736",0,"84.922",1085800000,15,"0.770526","0.338112","-1.1177","-2.10758","sp|P60709|ACTB_HUMAN;tr|G5E9R0|G5E9R0_HUMAN;tr|E7EVS6|E7EVS6_HUMAN;tr|C9JZR7|C9JZR7_HUMAN;tr|C9JTX5|C9JTX5_HUMAN","sp|P60709|ACTB_HUMAN",1240,"P60709","ACTB_HUMAN","Actin, cytoplasmic 1",null,"ACTB"]
["16.2068","16.1518","17.9242","16.6713",{"$nulls":3},"activation of protein kinase B activity;fat cell differentiation;negative regulation of cell migration;negative regulation of sequestering of triglyceride;phosphatidylserine acyl-chain remodeling;phospholipid transport;positive regulation of glucose import in response to insulin stimulus;positive regulation of insulin receptor signaling pathway;positive regulation of protein kinase B signaling;protein localization to nuclear pore","cholesterol binding;phosphatidylinositol-4-phosphate binding;phosphatidylserine binding;phospholipid transporter activity","cortical endoplasmic reticulum;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;nuclear membrane",{"$nulls":3},4,4,4,"6.7","6.7","6.7","101.19",0,"12.411",79280000,21,"0.664762","0.389317","-1.11852","-1.7838","sp|Q9BZF1|OSBL8_HUMAN;tr|F8VUA7|F8VUA7_HUMAN;tr|F8VQX7|F8VQX7_HUMAN","sp|Q9BZF1|OSBL8_HUMAN;tr|F8VUA7|F8VUA7_HUMAN;tr|F8VQX7|F8VQX7_HUMAN",2518,"Q9BZF1","OSBL8_HUMAN","Oxysterol-binding protein-related protein 8","RP-8;SBP-related protein 8","OSBPL8"]
["17.9306","17.6156","18.9769","18.8092",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;cardiac muscle cell proliferation;cellular response to glucagon stimulus;female meiotic nuclear division;intracellular signal transduction;mesoderm formation;negative regulation of activated T cell proliferation;negative regulation of cAMP-dependent protein kinase activity;negative regulation of meiotic nuclear division;regulation of transcription from RNA polymerase II promoter;renal water homeostasis;sarcomere organization","cAMP binding;cAMP-dependent protein kinase inhibitor activity;cAMP-dependent protein kinase regulator activity;protein domain specific binding;protein kinase A catalytic subunit binding;ubiquitin protein ligase binding","cAMP-dependent protein kinase complex;ciliary base;cytoplasm;cytosol;membrane;neuromuscular junction;nucleotide-activated protein kinase complex;plasma membrane raft;protein complex","Insulin signaling pathway",null,null,3,3,3,"10.8","10.8","10.8","42.981",0,"11.976",105360000,7,"1.61152","0.337202","-1.11989","-6.27593","sp|P10644|KAP0_HUMAN;tr|K7EM13|K7EM13_HUMAN;tr|K7EPB2|K7EPB2_HUMAN;tr|K7EPR5|K7EPR5_HUMAN;tr|K7EQK3|K7EQK3_HUMAN;tr|K7EMU2|K7EMU2_HUMAN;tr|X6RAV4|X6RAV4_HUMAN;tr|K7EMZ6|K7EMZ6_HUMAN;tr|K7EIE5|K7EIE5_HUMAN;tr|K7EID3|K7EID3_HUMAN;tr|K7EJ40|K7EJ40_HUMAN;tr|K7EK41|K7EK41_HUMAN","sp|P10644|KAP0_HUMAN;tr|K7EM13|K7EM13_HUMAN;tr|K7EPB2|K7EPB2_HUMAN",611,"P10644","KAP0_HUMAN","cAMP-dependent protein kinase type I-alpha regulatory subunit",null,"PRKAR1A"]
["15.582","14.9436","16.5644","16.2018",{"$nulls":9},1,1,1,"3.9","3.9","3.9","24.731","0.0034364","2.0809",11466000,4,"1.03297","0.298586","-1.12034","-3.05173","tr|F5H0Y3|F5H0Y3_HUMAN;sp|Q15773|MLF2_HUMAN","tr|F5H0Y3|F5H0Y3_HUMAN;sp|Q15773|MLF2_HUMAN",1721,"F5H0Y3","F5H0Y3_HUMAN",null,null,"MLF2"]
["17.1646","16.8138","18.287","17.9374",{"$nulls":3},"adaptive immune response;adherens junction organization;brain development;cell differentiation;cellular response to peptide hormone stimulus;central nervous system development;epidermal growth factor receptor signaling pathway;innate immune response;negative regulation of bone resorption;negative regulation of cell proliferation;negative regulation of ERK1 and ERK2 cascade;negative regulation of Golgi to plasma membrane protein transport;negative regulation of interleukin-6 production;negative regulation of kinase activity;negative regulation of low-density lipoprotein particle clearance;negative regulation of phagocytosis;oligodendrocyte differentiation;peptidyl-tyrosine autophosphorylation;positive regulation of MAP kinase activity;protein phosphorylation;regulation of cell proliferation;regulation of cytokine production;regulation of Fc receptor mediated stimulatory signaling pathway;T cell costimulation;T cell receptor signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding;identical protein binding;kinase activity;metal ion binding;non-membrane spanning protein tyrosine kinase activity;proline-rich region binding;protein C-terminus binding;protein kinase A catalytic subunit binding;protein phosphatase binding;protein tyrosine kinase activity;receptor binding","cell-cell junction;cytoplasm;cytosol;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane;membrane raft;plasma membrane","Epithelial cell signaling in Helicobacter pylori infection",null,null,2,2,2,"5.6","5.6","5.6","50.704",0,"3.462",56099000,7,"1.34348","0.337371","-1.12303","-4.53486","sp|P41240|CSK_HUMAN","sp|P41240|CSK_HUMAN",984,"P41240","CSK_HUMAN","Tyrosine-protein kinase CSK",null,"CSK"]
["17.1924","16.4506","18.1457","17.744",{"$nulls":3},"3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;skeletal system development;sulfate assimilation","adenylylsulfate kinase activity;ATP binding;nucleotidyltransferase activity;protein homodimerization activity;sulfate adenylyltransferase (ATP) activity","cytosol","Metabolic pathways;Purine metabolism;Selenocompound metabolism;Sulfur metabolism",null,null,3,3,3,"4.8","4.8","4.8","70.832",0,"3.9175",50652000,3,"0.932598","0.297096","-1.12336","-2.66335","sp|O43252|PAPS1_HUMAN","sp|O43252|PAPS1_HUMAN",236,"O43252","PAPS1_HUMAN","Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1","APS synthase 1;APSS 1","PAPSS1"]
["15.982","16.4991","17.1293","17.5997",{"$nulls":3},"angiogenesis;cell differentiation;exocyst localization;exocytosis","SNARE binding","exocyst;extracellular space",{"$nulls":3},1,1,1,"2.4","2.4","2.4","72.66","0.0010953","2.5774",42179000,4,"1.07263","0.305267","-1.12392","-3.21597","sp|Q03169|TNAP2_HUMAN","sp|Q03169|TNAP2_HUMAN",1438,"Q03169","TNAP2_HUMAN","Tumor necrosis factor alpha-induced protein 2","NF alpha-induced protein 2","TNFAIP2"]
["19.5702","18.8826","20.2493","20.4517",{"$nulls":3},"cellular amino acid biosynthetic process;chemical synaptic transmission;glutamate biosynthetic process;glutamate secretion;glutamine catabolic process;protein homotetramerization;regulation of respiratory gaseous exchange by neurological system process;suckling behavior","glutaminase activity","cytosol;mitochondrial matrix;mitochondrion","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Central carbon metabolism in cancer;D-Glutamine and D-glutamate metabolism;GABAergic synapse;Glutamatergic synapse;Metabolic pathways;MicroRNAs in cancer;Proximal tubule bicarbonate reclamation",null,null,5,5,5,"12.4","12.4","12.4","73.46",0,"61.252",429780000,45,"1.05371","0.30515","-1.12412","-3.13679","sp|O94925|GLSK_HUMAN;tr|H7BZD1|H7BZD1_HUMAN","sp|O94925|GLSK_HUMAN",402,"O94925","GLSK_HUMAN","Glutaminase kidney isoform, mitochondrial","LS","GLS"]
["17.2934","16.6953","18.5668","17.6786",{"$nulls":3},"DNA replication","DNA binding;DNA-directed DNA polymerase activity","nucleoplasm",{"$nulls":3},3,3,3,"8.8","8.8","8.8","49.612",0,"5.7409",48761000,2,"0.770486","0.337709","-1.12836","-2.10745","tr|F8W8R3|F8W8R3_HUMAN;sp|P49005|DPOD2_HUMAN;tr|A0A087WWF6|A0A087WWF6_HUMAN;tr|C9IZD2|C9IZD2_HUMAN;tr|C9J8Z7|C9J8Z7_HUMAN;tr|C9JLE1|C9JLE1_HUMAN;tr|H7C1B3|H7C1B3_HUMAN;tr|C9JHC7|C9JHC7_HUMAN","tr|F8W8R3|F8W8R3_HUMAN;sp|P49005|DPOD2_HUMAN;tr|A0A087WWF6|A0A087WWF6_HUMAN;tr|C9IZD2|C9IZD2_HUMAN;tr|C9J8Z7|C9J8Z7_HUMAN;tr|C9JLE1|C9JLE1_HUMAN",1064,"F8W8R3","F8W8R3_HUMAN",null,null,"POLD2"]
[1,"15.7426","18.0018",1,{"$nulls":3},"axon guidance;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;leukocyte migration;negative regulation of translation;positive regulation of cell migration;stress granule assembly","identical protein binding;phosphatidylinositol binding;protein kinase binding;RNA binding;SH3/SH2 adaptor activity","cell projection;cytoplasmic stress granule;cytosol;focal adhesion;plasma membrane",{"$nulls":3},1,1,1,"2.1","2.1","2.1","59.68","0.0047603","2.0053",8567200,4,"0.0318961","0.963251","-1.12961","-0.100394","sp|Q14451|GRB7_HUMAN","sp|Q14451|GRB7_HUMAN",1623,"Q14451","GRB7_HUMAN","Growth factor receptor-bound protein 7",null,"GRB7"]
["18.4073","18.227","19.6945","19.1995",{"$nulls":3},"cholesterol biosynthetic process;cholesterol biosynthetic process via 24,25-dihydrolanosterol;regulation of cholesterol biosynthetic process;steroid biosynthetic process;sterol metabolic process","heme binding;iron ion binding;sterol 14-demethylase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;organelle membrane;plasma membrane","Metabolic pathways;Steroid biosynthesis",null,null,5,5,5,"12.3","12.3","12.3","56.805",0,"14.897",227980000,17,"1.29866","0.33281","-1.12983","-4.29001","sp|Q16850|CP51A_HUMAN;tr|A0A0C4DFL7|A0A0C4DFL7_HUMAN","sp|Q16850|CP51A_HUMAN;tr|A0A0C4DFL7|A0A0C4DFL7_HUMAN",1759,"Q16850","CP51A_HUMAN","Lanosterol 14-alpha demethylase","DM","CYP51A1"]
["19.3279","19.7066","21.1358","20.1594",{"$nulls":4},"receptor activity","integral component of membrane",{"$nulls":3},3,3,3,"7.3","7.3","7.3","72.647",0,"7.4695",224900000,13,"0.786478","0.33316","-1.13038","-2.15886","tr|J3KQI6|J3KQI6_HUMAN;sp|Q9BX79|STRA6_HUMAN;tr|I3L2B6|I3L2B6_HUMAN;tr|I3NI08|I3NI08_HUMAN","tr|J3KQI6|J3KQI6_HUMAN;sp|Q9BX79|STRA6_HUMAN;tr|I3L2B6|I3L2B6_HUMAN",2492,"J3KQI6","J3KQI6_HUMAN",null,null,"STRA6"]
["20.2947","20.441","21.4301","21.5675",{"$nulls":9},1,1,1,"38.5","38.5","38.5","4.1316","0.00038715","3.0839",20154000,1,"2.10902","0.39028","-1.13095","-11.271","tr|H3BU01|H3BU01_HUMAN;sp|O60294|TYW4_HUMAN","tr|H3BU01|H3BU01_HUMAN;sp|O60294|TYW4_HUMAN",285,"H3BU01","H3BU01_HUMAN",null,null,"LCMT2"]
["18.8789","19.8136","20.4648","20.4906",{"$nulls":9},3,3,3,"8.3","8.3","8.3","31.008",0,"17.243",102980000,16,"0.864485","0.301672","-1.13149","-2.41996","tr|A2AB27|A2AB27_HUMAN;sp|P36915|GNL1_HUMAN","tr|A2AB27|A2AB27_HUMAN;sp|P36915|GNL1_HUMAN",950,"A2AB27","A2AB27_HUMAN",null,null,"GNL1"]
["15.13","14.8994","16.1247","16.1685",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;negative regulation of double-strand break repair;negative regulation of histone H2A K63-linked ubiquitination;protein polyubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of embryonic development","thyroid hormone receptor binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;nuclear speck;nucleoplasm;nucleus","Ubiquitin mediated proteolysis",null,null,3,3,3,"2.4","2.4","2.4","220.43",0,"22.984",46916000,17,"1.97546","0.406655","-1.13187","-9.64406","sp|Q14669|TRIPC_HUMAN;tr|H7C1L9|H7C1L9_HUMAN;tr|G5E9G6|G5E9G6_HUMAN","sp|Q14669|TRIPC_HUMAN",1635,"Q14669","TRIPC_HUMAN","E3 ubiquitin-protein ligase TRIP12",null,"TRIP12"]
["17.377","17.3929","18.7616","18.2765",{"$nulls":3},"apoptotic process;branching involved in blood vessel morphogenesis;cell differentiation involved in embryonic placenta development;cell morphogenesis;central nervous system development;endocardium development;hepatocyte apoptotic process;hippo signaling;intracellular signal transduction;keratinocyte differentiation;negative regulation of canonical Wnt signaling pathway;negative regulation of cell proliferation;negative regulation of organ growth;neural tube formation;peptidyl-serine phosphorylation;positive regulation of apoptotic process;positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;positive regulation of fat cell differentiation;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein binding;positive regulation of protein phosphorylation;primitive hemopoiesis;protein autophosphorylation;protein phosphorylation;protein stabilization;regulation of cell differentiation involved in embryonic placenta development;regulation of mitotic cell cycle;signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;identical protein binding;magnesium ion binding;protein dimerization activity;protein homodimerization activity;protein kinase activity;protein serine/threonine kinase activator activity;protein serine/threonine kinase activity;transcription factor binding","cytoplasm;cytosol;nuclear body;nucleoplasm;nucleus;protein complex","FoxO signaling pathway;MAPK signaling pathway;Non-small cell lung cancer;Pathways in cancer;Ras signaling pathway",null,null,4,4,4,"8.8","8.8","8.8","55.63",0,"8.5518",93057000,7,"1.36788","0.332058","-1.13412","-4.67321","sp|Q13043|STK4_HUMAN;tr|F5H5B4|F5H5B4_HUMAN;tr|A0A087WYT4|A0A087WYT4_HUMAN;tr|A0A087WVN8|A0A087WVN8_HUMAN;sp|Q13188|STK3_HUMAN","sp|Q13043|STK4_HUMAN;tr|F5H5B4|F5H5B4_HUMAN",1514,"Q13043","STK4_HUMAN","Serine/threonine-protein kinase 4",null,"STK4"]
["16.7691","16.7358","18.2862","17.4881",{"$nulls":3},"alanyl-tRNA aminoacylation","alanine-tRNA ligase activity;ATP binding;metal ion binding;nucleic acid binding;Ser-tRNA(Ala) hydrolase activity","cytoplasm;nucleus",{"$nulls":3},2,2,2,"8.5","8.5","8.5","45.479",0,"4.5746",37260000,12,"0.979675","0.294466","-1.13468","-2.84085","sp|Q9BTE6|AASD1_HUMAN;tr|C9J5N1|C9J5N1_HUMAN;tr|L7N2F4|L7N2F4_HUMAN","sp|Q9BTE6|AASD1_HUMAN;tr|C9J5N1|C9J5N1_HUMAN;tr|L7N2F4|L7N2F4_HUMAN",2445,"Q9BTE6","AASD1_HUMAN","Alanyl-tRNA editing protein Aarsd1",null,"AARSD1"]
["16.1262","16.4499","17.7986","17.0494",{"$nulls":9},1,1,1,"5.7","5.7","5.7","24.322",0,"15.805",14789000,5,"0.96479","0.294061","-1.13596","-2.78387","tr|B7ZBC9|B7ZBC9_HUMAN;tr|B7ZBC8|B7ZBC8_HUMAN;sp|O75449|KTNA1_HUMAN","tr|B7ZBC9|B7ZBC9_HUMAN;tr|B7ZBC8|B7ZBC8_HUMAN;sp|O75449|KTNA1_HUMAN",346,"B7ZBC9","B7ZBC9_HUMAN",null,null,"KATNA1"]
["20.1898","19.4566","21.2245","20.7088",{"$nulls":3},"base-excision repair;DNA damage response, detection of DNA damage;DNA recombination;DNA repair;DNA replication;DNA-dependent DNA replication;double-strand break repair via homologous recombination;error-free translesion synthesis;error-prone translesion synthesis;G1/S transition of mitotic cell cycle;interstrand cross-link repair;mismatch repair;nucleotide-excision repair;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;protein localization to chromosome;regulation of cellular response to heat;regulation of signal transduction by p53 class mediator;telomere maintenance;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","damaged DNA binding;G-rich strand telomeric DNA binding;metal ion binding;single-stranded DNA binding","DNA replication factor A complex;nuclear chromosome, telomeric region;nucleoplasm;nucleus;PML body","DNA replication;Fanconi anemia pathway;Homologous recombination;Mismatch repair;Nucleotide excision repair",null,null,8,8,8,"21.8","21.8","21.8","68.137",0,"127.4",421270000,49,"0.901727","0.3009","-1.14344","-2.55115","sp|P27694|RFA1_HUMAN;tr|I3L4R8|I3L4R8_HUMAN;tr|I3L2M5|I3L2M5_HUMAN","sp|P27694|RFA1_HUMAN;tr|I3L4R8|I3L4R8_HUMAN",824,"P27694","RFA1_HUMAN","Replication protein A 70 kDa DNA-binding subunit","P-A p70","RPA1"]
["17.7177","17.7529","20.2801","17.4863",{"$nulls":3},"cotranslational protein targeting to membrane;IRE1-mediated unfolded protein response;positive regulation of cell proliferation",null,"endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Protein processing in endoplasmic reticulum",null,null,2,2,2,"14.3","14.3","14.3","32.235",0,"3.5626",46791000,9,"0.303091","0.725675","-1.1479","-0.821664","sp|P43307|SSRA_HUMAN;tr|C9JBX5|C9JBX5_HUMAN;tr|C9J3L8|C9J3L8_HUMAN;tr|C9J5W0|C9J5W0_HUMAN;tr|E9PAL7|E9PAL7_HUMAN;tr|C9IZQ1|C9IZQ1_HUMAN","sp|P43307|SSRA_HUMAN;tr|C9JBX5|C9JBX5_HUMAN;tr|C9J3L8|C9J3L8_HUMAN;tr|C9J5W0|C9J5W0_HUMAN;tr|E9PAL7|E9PAL7_HUMAN;tr|C9IZQ1|C9IZQ1_HUMAN",1009,"P43307","SSRA_HUMAN","Translocon-associated protein subunit alpha","RAP-alpha","SSR1"]
["19.1353","19.5504","20.7448","20.2438",{"$nulls":3},"positive regulation of translation;positive regulation of translational initiation","N6-methyladenosine-containing RNA binding;ribosome binding;RNA binding","cytoplasm",{"$nulls":3},6,6,3,"15.7","15.7","11.1","60.873",0,"10.728",220080000,16,"1.14632","0.312517","-1.15147","-3.53902","sp|Q9BYJ9|YTHD1_HUMAN","sp|Q9BYJ9|YTHD1_HUMAN",2511,"Q9BYJ9","YTHD1_HUMAN","YTH domain-containing family protein 1 {ECO:0000305}",null,"YTHDF1"]
["17.6276","17.7992","19.0252","18.7167",{"$nulls":3},"actin cytoskeleton reorganization;cell adhesion","actin binding",{"$nulls":4},2,2,2,"14.4","14.4","14.4","21.561","0.0047587","2.0047",34652000,4,"1.64831","0.330681","-1.15751","-6.55751","tr|B0QYP8|B0QYP8_HUMAN;tr|A0A087WZB5|A0A087WZB5_HUMAN;sp|Q9HBI1|PARVB_HUMAN","tr|B0QYP8|B0QYP8_HUMAN;tr|A0A087WZB5|A0A087WZB5_HUMAN;sp|Q9HBI1|PARVB_HUMAN",2636,"B0QYP8","B0QYP8_HUMAN",null,null,"PARVB"]
["15.3199","15.8013","16.8963","16.5488",{"$nulls":3},"dephosphorylation of RNA polymerase II C-terminal domain;snRNA transcription;snRNA transcription from RNA polymerase II promoter","CTD phosphatase activity;metal ion binding;protein serine/threonine phosphatase activity","cytoplasm;cytosol;DNA-directed RNA polymerase II, holoenzyme;nucleolus;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"2.3","2.3","2.3","69.508",0,"23.558",27536000,8,"1.22542","0.316427","-1.16195","-3.91403","sp|Q8IXW5|RPAP2_HUMAN","sp|Q8IXW5|RPAP2_HUMAN",2023,"Q8IXW5","RPAP2_HUMAN","Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2",null,"RPAP2"]
["17.6261","18.1622","19.496","18.6363",{"$nulls":9},2,2,2,"8.5","8.5","8.5","34.252",0,"5.8573",56890000,6,"0.833351","0.312749","-1.17204","-2.31361","tr|C9J4Q3|C9J4Q3_HUMAN;tr|B8ZZG1|B8ZZG1_HUMAN;sp|Q9NZW5|MPP6_HUMAN;tr|C9JGI8|C9JGI8_HUMAN","tr|C9J4Q3|C9J4Q3_HUMAN;tr|B8ZZG1|B8ZZG1_HUMAN;sp|Q9NZW5|MPP6_HUMAN;tr|C9JGI8|C9JGI8_HUMAN",2765,"C9J4Q3","C9J4Q3_HUMAN",null,null,"MPP6"]
["18.1629","17.7773","19.5234","18.763",{"$nulls":4},"GTP binding;GTPase activity","cytosol;plasma membrane",{"$nulls":3},2,1,1,"17.2","11.5","11.5","13.584","0.0010619","2.3468",29104000,4,"0.956411","0.29814","-1.17314","-2.75215","tr|A0A087WWB9|A0A087WWB9_HUMAN;sp|P51153|RAB13_HUMAN","tr|A0A087WWB9|A0A087WWB9_HUMAN;sp|P51153|RAB13_HUMAN",1132,"A0A087WWB9","A0A087WWB9_HUMAN",null,null,"RAB13"]
["13.0063","14.7215","13.9065","16.1706",{"$nulls":3},"artery development;neural fold bending;ventricular septum development",null,"extracellular exosome;membrane;nucleus",{"$nulls":3},3,3,3,"4.1","4.1","4.1","120.27",0,"3.4868",22082000,6,"0.305255","0.724154","-1.17464","-0.827088","sp|Q86V48|LUZP1_HUMAN","sp|Q86V48|LUZP1_HUMAN",1984,"Q86V48","LUZP1_HUMAN","Leucine zipper protein 1",null,"LUZP1"]
["14.4985","14.0227","15.5064","15.3644",{"$nulls":9},1,1,1,"2.3","2.3","2.3","68.12",0,"3.6251",10471000,3,"1.37813","0.333702","-1.17479","-4.73241","tr|A8MSZ8|A8MSZ8_HUMAN;tr|A6NN50|A6NN50_HUMAN;sp|O75147|OBSL1_HUMAN","tr|A8MSZ8|A8MSZ8_HUMAN;tr|A6NN50|A6NN50_HUMAN;sp|O75147|OBSL1_HUMAN",322,"A8MSZ8","A8MSZ8_HUMAN",null,null,"OBSL1"]
["17.2366","17.3881","18.6797","18.296",{"$nulls":3},"mitochondrial tRNA 3'-trailer cleavage, endonucleolytic;mitochondrial tRNA processing;tRNA 3'-end processing","3'-tRNA processing endoribonuclease activity;metal ion binding;RNA binding;tRNA-specific ribonuclease activity","mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleoplasm;nucleus","RNA transport",null,null,6,6,6,"12.1","12.1","12.1","92.218",0,"12.375",144420000,15,"1.53114","0.317867","-1.17553","-5.69922","sp|Q9BQ52|RNZ2_HUMAN;tr|E7ES68|E7ES68_HUMAN;tr|G5E9D5|G5E9D5_HUMAN;tr|H7C2I4|H7C2I4_HUMAN;tr|V9GZ72|V9GZ72_HUMAN;tr|V9GYS7|V9GYS7_HUMAN","sp|Q9BQ52|RNZ2_HUMAN;tr|E7ES68|E7ES68_HUMAN;tr|G5E9D5|G5E9D5_HUMAN",2412,"Q9BQ52","RNZ2_HUMAN","Zinc phosphodiesterase ELAC protein 2",null,"ELAC2"]
["16.9252","16.2848","18.1912","17.3705",{"$nulls":3},"activation of GTPase activity;angiogenesis;bone remodeling;branching involved in mammary gland duct morphogenesis;cAMP metabolic process;cell adhesion;cell chemotaxis;cell migration;cell motility;ephrin receptor signaling pathway;intrinsic apoptotic signaling pathway in response to DNA damage;keratinocyte differentiation;lens fiber cell morphogenesis;mammary gland epithelial cell proliferation;multicellular organism development;negative regulation of protein kinase B signaling;osteoblast differentiation;osteoclast differentiation;positive regulation of protein localization to plasma membrane;protein kinase B signaling;regulation of angiogenesis;regulation of blood vessel endothelial cell migration;regulation of cell adhesion mediated by integrin;regulation of ERK1 and ERK2 cascade;regulation of lamellipodium assembly;response to growth factor","ATP binding;cadherin binding;ephrin receptor activity;transmembrane receptor protein tyrosine kinase activity;virus receptor activity","cell surface;focal adhesion;integral component of plasma membrane;intracellular;lamellipodium;lamellipodium membrane;leading edge membrane;plasma membrane;ruffle membrane","Axon guidance;MAPK signaling pathway;PI3K-Akt signaling pathway;Rap1 signaling pathway;Ras signaling pathway",null,null,5,5,5,"6.6","6.6","6.6","108.27",0,"14.338",104740000,17,"0.81704","0.32291","-1.17588","-2.25905","sp|P29317|EPHA2_HUMAN","sp|P29317|EPHA2_HUMAN",845,"P29317","EPHA2_HUMAN","Ephrin type-A receptor 2",null,"EPHA2"]
["18.6207","17.8653","19.6387","19.1995",{"$nulls":3},"intracellular distribution of mitochondria",null,"cytoplasm",{"$nulls":3},9,9,1,12,12,"1.1","138.23",0,"34.859",327490000,34,"0.940239","0.297016","-1.1761","-2.69163","tr|I3L2B0|I3L2B0_HUMAN","tr|I3L2B0|I3L2B0_HUMAN",3108,"I3L2B0","I3L2B0_HUMAN",null,null,"CLUH"]
["16.5183","16.8413","17.6357","18.0774",{"$nulls":5},"intracellular membrane-bounded organelle;nucleolus;nucleus",{"$nulls":3},1,1,1,"7.3","7.3","7.3","17.198","0.00075472","2.8527",10043000,2,"1.30069","0.333211","-1.1768","-4.30081","tr|D6RIC3|D6RIC3_HUMAN;sp|Q9Y3C1|NOP16_HUMAN;tr|A0A0C4DGU5|A0A0C4DGU5_HUMAN;tr|A0A087X1T1|A0A087X1T1_HUMAN;tr|A0A087X2G6|A0A087X2G6_HUMAN","tr|D6RIC3|D6RIC3_HUMAN;sp|Q9Y3C1|NOP16_HUMAN;tr|A0A0C4DGU5|A0A0C4DGU5_HUMAN;tr|A0A087X1T1|A0A087X1T1_HUMAN;tr|A0A087X2G6|A0A087X2G6_HUMAN",2982,"D6RIC3","D6RIC3_HUMAN",null,null,"NOP16"]
["17.1379","17.2222","18.4643","18.251",{"$nulls":3},"DNA strand elongation involved in DNA replication;DNA strand elongation involved in mitotic DNA replication;inner cell mass cell proliferation","3'-5' DNA helicase activity","cytoplasm;GINS complex;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"7.1","7.1","7.1","22.988",0,"8.9699",36995000,9,"2.02927","0.413429","-1.17761","-10.27","sp|Q14691|PSF1_HUMAN","sp|Q14691|PSF1_HUMAN",1639,"Q14691","PSF1_HUMAN","DNA replication complex GINS protein PSF1",null,"GINS1"]
["12.5471","12.9805","14.0727","13.8131",{"$nulls":3},"Golgi to endosome transport;protein transport",null,"cytosol;extracellular exosome",{"$nulls":3},1,1,1,"0.6","0.6","0.6","190.36","0.0097752","1.689",11209000,2,"1.36696","0.332817","-1.17912","-4.66797","sp|Q7Z3U7|MON2_HUMAN","sp|Q7Z3U7|MON2_HUMAN",1949,"Q7Z3U7","MON2_HUMAN","Protein MON2 homolog",null,"MON2"]
["16.9541","17.0172","18.0981","18.2389",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;ribosomal small subunit assembly","GTP binding;ribosomal small subunit binding;RNA binding;rRNA binding","cytosol;mitochondrial inner membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},1,1,1,"2.7","2.7","2.7","48.349",0,"6.6272",24828000,1,"2.37428","0.4687","-1.18285","-15.3377","sp|O75616|ERAL1_HUMAN","sp|O75616|ERAL1_HUMAN",356,"O75616","ERAL1_HUMAN","GTPase Era, mitochondrial","ERA;-ERA","ERAL1"]
["15.0819","14.1715","15.8047","15.8169",{"$nulls":3},"microtubule-based movement","ATP binding;ATPase activity;microtubule binding;microtubule motor activity","cytoplasm;kinesin complex;microtubule",{"$nulls":3},3,3,3,"2.7","2.7","2.7","187.18",0,"10.362",32190000,5,"0.915527","0.293122","-1.18411","-2.60091","sp|Q7Z4S6|KI21A_HUMAN;tr|H0YIM7|H0YIM7_HUMAN;sp|O75037|KI21B_HUMAN","sp|Q7Z4S6|KI21A_HUMAN",1956,"Q7Z4S6","KI21A_HUMAN","Kinesin-like protein KIF21A",null,"KIF21A"]
["16.5733",1,"18.9631",1,{"$nulls":5},"nuclear body;nucleoplasm",{"$nulls":3},1,1,1,"2.5","2.5","2.5","59.388",0,"5.5307",24804000,3,"0.0319387","0.963465","-1.19493","-0.100524","tr|A0A096LNN3|A0A096LNN3_HUMAN;tr|A0A096LNW1|A0A096LNW1_HUMAN;tr|A0A096LNL9|A0A096LNL9_HUMAN;sp|P46100|ATRX_HUMAN","tr|A0A096LNN3|A0A096LNN3_HUMAN;tr|A0A096LNW1|A0A096LNW1_HUMAN;tr|A0A096LNL9|A0A096LNL9_HUMAN;sp|P46100|ATRX_HUMAN",1023,"A0A096LNN3","A0A096LNN3_HUMAN",null,null,"ATRX"]
["19.8946","17.6815","20.0962","19.8732",{"$nulls":3},"ATP hydrolysis coupled proton transport","proton-transporting ATPase activity, rotational mechanism","proton-transporting two-sector ATPase complex, catalytic domain",{"$nulls":3},3,3,3,"26.6","26.6","26.6","23.539",0,"6.7525",99735000,7,"0.403941","0.616518","-1.19661","-1.07594","tr|C9J8H1|C9J8H1_HUMAN;sp|P36543|VATE1_HUMAN","tr|C9J8H1|C9J8H1_HUMAN;sp|P36543|VATE1_HUMAN",944,"C9J8H1","C9J8H1_HUMAN",null,null,"ATP6V1E1"]
["19.0429","18.6087","20.2048","19.8515",{"$nulls":3},"AMP biosynthetic process;aspartate metabolic process;cellular response to electrical stimulus;'de novo' AMP biosynthetic process;immune system process;IMP metabolic process;purine ribonucleoside monophosphate biosynthetic process;response to ammonium ion;response to purine-containing compound","adenylosuccinate synthase activity;GTP binding;metal ion binding;phosphate ion binding","cytoplasm;cytosol;extracellular exosome;plasma membrane","Alanine, aspartate and glutamate metabolism;Metabolic pathways;Purine metabolism",null,null,4,4,4,"11.8","11.8","11.8","50.097",0,"21.038",200670000,12,"1.29971","0.333902","-1.20236","-4.29562","sp|P30520|PURA2_HUMAN","sp|P30520|PURA2_HUMAN",873,"P30520","PURA2_HUMAN","Adenylosuccinate synthetase isozyme 2 {ECO:0000255|HAMAP-Rule:MF_03127}","dSS 2 {ECO:0000255|HAMAP-Rule:MF_03127};MPSase 2 {ECO:0000255|HAMAP-Rule:MF_03127}","ADSS"]
["19.4526","18.476","20.4324","19.9103",{"$nulls":3},"protein phosphorylation;regulation of signal transduction by p53 class mediator;tRNA processing;tRNA threonylcarbamoyladenosine metabolic process","ATP binding;hydrolase activity;p53 binding;protein serine/threonine kinase activity","cytosol;EKC/KEOPS complex;membrane;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"16.6","16.6","16.6","28.16",0,"5.8786",98947000,11,"0.792941","0.333091","-1.20698","-2.17983","sp|Q96S44|PRPK_HUMAN;tr|Q5JZ02|Q5JZ02_HUMAN","sp|Q96S44|PRPK_HUMAN",2351,"Q96S44","PRPK_HUMAN","TP53-regulating kinase",null,"TP53RK"]
["16.2689","15.6237","17.8976","16.4356",{"$nulls":3},"cell division;ER to Golgi vesicle-mediated transport;establishment of mitotic spindle orientation;Golgi organization;meiotic cell cycle;mitotic cell cycle checkpoint;mitotic metaphase plate congression;mitotic sister chromatid segregation;mitotic spindle assembly checkpoint;protein complex assembly;protein localization to kinetochore;protein transport;regulation of exit from mitosis;retrograde vesicle-mediated transport, Golgi to ER;sister chromatid cohesion","centromeric DNA binding","condensed chromosome kinetochore;cytosol;Dsl1/NZR complex;endoplasmic reticulum;endoplasmic reticulum membrane;kinetochore;kinetochore microtubule;membrane;nucleus;RZZ complex;spindle pole",{"$nulls":3},5,5,5,"10.9","10.9","10.9","88.828",0,"23.222",69127000,23,"0.574687","0.463099","-1.22031","-1.52724","sp|O43264|ZW10_HUMAN;tr|F5H3C1|F5H3C1_HUMAN","sp|O43264|ZW10_HUMAN",237,"O43264","ZW10_HUMAN","Centromere/kinetochore protein zw10 homolog",null,"ZW10"]
["16.6776","16.389","18.4177","17.09",{"$nulls":3},"miRNA metabolic process;positive regulation of RNA interference;pre-miRNA export from nucleus;protein export from nucleus;regulation of protein export from nucleus","mRNA binding;nuclear export signal receptor activity;pre-miRNA binding;pre-miRNA transporter activity;Ran GTPase binding;RNA binding;tRNA binding","cytoplasm;cytosol;micro-ribonucleoprotein complex;nuclear RNA export factor complex;nucleoplasm;nucleus;RNA nuclear export complex","RNA transport",null,null,6,6,6,"7.3","7.3","7.3","136.31",0,"14.287",120070000,19,"0.669132","0.387587","-1.22057","-1.79666","sp|Q9HAV4|XPO5_HUMAN;tr|E2QRM3|E2QRM3_HUMAN","sp|Q9HAV4|XPO5_HUMAN",2630,"Q9HAV4","XPO5_HUMAN","Exportin-5","xp5","XPO5"]
["18.5323","18.1537","19.987","19.1484",{"$nulls":4},"phosphoprotein phosphatase activity",{"$nulls":4},3,3,3,9,9,9,"47.815",0,"5.3838",109410000,6,"0.932221","0.296629","-1.22469","-2.66196","tr|E7ETC2|E7ETC2_HUMAN;sp|Q08209|PP2BA_HUMAN;tr|Q5F2F8|Q5F2F8_HUMAN;sp|P16298|PP2BB_HUMAN;tr|E9PPC8|E9PPC8_HUMAN;tr|E9PK68|E9PK68_HUMAN;tr|H0YC26|H0YC26_HUMAN;sp|P48454|PP2BC_HUMAN","tr|E7ETC2|E7ETC2_HUMAN;sp|Q08209|PP2BA_HUMAN;tr|Q5F2F8|Q5F2F8_HUMAN;sp|P16298|PP2BB_HUMAN",1469,"E7ETC2","E7ETC2_HUMAN","Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273}",null,"PPP3CA"]
["18.188","18.7118","19.871","19.4801",{"$nulls":3},"cotranslational protein targeting to membrane;IRE1-mediated unfolded protein response;SRP-dependent cotranslational protein targeting to membrane;vesicle-mediated transport","GTP binding;GTPase activity;RNA binding;signal recognition particle binding","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;membrane;signal recognition particle receptor complex","Protein export",null,null,6,6,6,"15.4","15.4","15.4","69.81",0,"33.608",277830000,21,"1.19183","0.325032","-1.22563","-3.75104","sp|P08240|SRPR_HUMAN","sp|P08240|SRPR_HUMAN",560,"P08240","SRPRA_HUMAN","Signal recognition particle receptor subunit alpha","R-alpha","SRPRA"]
["16.9972","16.9099","18.4261","17.9385",{"$nulls":3},"D-ribose metabolic process;pentose-phosphate shunt;pentose-phosphate shunt, non-oxidative branch","identical protein binding;monosaccharide binding;ribose-5-phosphate isomerase activity","cytosol;intracellular membrane-bounded organelle","Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,2,2,2,"10.3","10.3","10.3","33.269","0.00040016","3.3663",38515000,10,"1.4166","0.33165","-1.22871","-4.9606","sp|P49247|RPIA_HUMAN","sp|P49247|RPIA_HUMAN",1069,"P49247","RPIA_HUMAN","Ribose-5-phosphate isomerase",null,"RPIA"]
["13.5049","13.8007","14.7872","14.9824",{"$nulls":3},"apoptotic DNA fragmentation;conversion of ds siRNA to ss siRNA;conversion of ds siRNA to ss siRNA involved in RNA interference;miRNA loading onto RISC involved in gene silencing by miRNA;miRNA metabolic process;negative regulation of Schwann cell proliferation;negative regulation of transcription from RNA polymerase II promoter;nerve development;neuron projection morphogenesis;peripheral nervous system myelin formation;positive regulation of myelination;positive regulation of Schwann cell differentiation;pre-miRNA processing;production of miRNAs involved in gene silencing by miRNA;production of siRNA involved in RNA interference;RNA phosphodiester bond hydrolysis, endonucleolytic;siRNA loading onto RISC involved in RNA interference;targeting of mRNA for destruction involved in RNA interference","ATP binding;deoxyribonuclease I activity;DNA binding;double-stranded RNA binding;endoribonuclease activity;helicase activity;metal ion binding;pre-miRNA binding;protein domain specific binding;ribonuclease III activity;siRNA binding","ARC complex;axon;cytoplasm;cytosol;dendrite;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;growth cone;micro-ribonucleoprotein complex;nucleus;RISC-loading complex","MicroRNAs in cancer",null,null,1,1,1,"0.6","0.6","0.6","218.68",0,"6.6728",19320000,7,"1.69756","0.346462","-1.23198","-6.95292","sp|Q9UPY3|DICER_HUMAN","sp|Q9UPY3|DICER_HUMAN",2928,"Q9UPY3","DICER_HUMAN","Endoribonuclease Dicer",null,"DICER1"]
["18.7478","18.5598","20.3631","19.4135",{"$nulls":4},"ion transmembrane transporter activity","integral component of membrane;mitochondrial membrane;mitochondrion",{"$nulls":3},6,6,6,"27.1","27.1","27.1","35.503",0,"15.349",102620000,13,"0.901607","0.300452","-1.23457","-2.55072","tr|A0A0A0MS41|A0A0A0MS41_HUMAN;sp|Q9BWM7|SFXN3_HUMAN;tr|S4R3N9|S4R3N9_HUMAN","tr|A0A0A0MS41|A0A0A0MS41_HUMAN;sp|Q9BWM7|SFXN3_HUMAN;tr|S4R3N9|S4R3N9_HUMAN",2487,"A0A0A0MS41","A0A0A0MS41_HUMAN","Sideroflexin {ECO:0000256|RuleBase:RU362000}",null,"SFXN3"]
["16.8876","16.0893","18.1652","17.3006",{"$nulls":9},2,2,2,"11.1","11.1","11.1","36.271",0,"7.4266",27904000,9,"0.772867","0.3382","-1.24442","-2.11506","tr|G3V340|G3V340_HUMAN;sp|Q13033|STRN3_HUMAN;tr|G3V3G7|G3V3G7_HUMAN;tr|H0YJZ4|H0YJZ4_HUMAN;tr|H0YJT2|H0YJT2_HUMAN","tr|G3V340|G3V340_HUMAN;sp|Q13033|STRN3_HUMAN;tr|G3V3G7|G3V3G7_HUMAN;tr|H0YJZ4|H0YJZ4_HUMAN;tr|H0YJT2|H0YJT2_HUMAN",1513,"G3V340","G3V340_HUMAN",null,null,"STRN3"]
["15.5037","15.0696","16.875","16.1955",{"$nulls":9},2,2,2,"7.2","7.2","7.2","60.626","0.003762","2.0518",22306000,2,"1.0441","0.300719","-1.2486","-3.09716","tr|A0A0A0MR08|A0A0A0MR08_HUMAN;sp|O94966|UBP19_HUMAN;tr|E7ESU0|E7ESU0_HUMAN;tr|E7EST9|E7EST9_HUMAN;tr|B5MEG5|B5MEG5_HUMAN","tr|A0A0A0MR08|A0A0A0MR08_HUMAN;sp|O94966|UBP19_HUMAN;tr|E7ESU0|E7ESU0_HUMAN;tr|E7EST9|E7EST9_HUMAN;tr|B5MEG5|B5MEG5_HUMAN",404,"A0A0A0MR08","A0A0A0MR08_HUMAN",null,null,"USP19"]
["12.8754","11.416","14.0687","12.7244",{"$nulls":3},"cell death;cellular protein modification process;cellular response to DNA damage stimulus;DNA repair;inflammatory response;protein ADP-ribosylation;regulation of telomerase activity;response to drug","DNA binding;enzyme binding;NAD+ ADP-ribosyltransferase activity","cytoplasm;cytosol;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleus;spindle microtubule","Apoptosis;Base excision repair;Necroptosis",null,null,1,1,1,"0.7","0.7","0.7","192.59","0.0097529","1.6765",8925000,1,"0.475554","0.52872","-1.25084","-1.2608","sp|Q9UKK3|PARP4_HUMAN","sp|Q9UKK3|PARP4_HUMAN",2872,"Q9UKK3","PARP4_HUMAN","Poly [ADP-ribose] polymerase 4","ARP-4","PARP4"]
["15.5547","15.4034","17.0046","16.4592",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;aorta morphogenesis;auditory receptor cell stereocilium organization;cargo loading into COPII-coated vesicle;cochlear nucleus development;COPII vesicle coating;coronary artery morphogenesis;ER to Golgi vesicle-mediated transport;intracellular protein transport;lung lobe morphogenesis;neural tube closure;outflow tract morphogenesis;pulmonary artery morphogenesis;regulation of cargo loading into COPII-coated vesicle;regulation of establishment of planar polarity involved in neural tube closure","zinc ion binding","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane","Protein processing in endoplasmic reticulum",null,null,2,2,2,"2.6","2.6","2.6","137.42",0,"14.229",25277000,5,"1.32396","0.332301","-1.25285","-4.4268","sp|O95487|SC24B_HUMAN","sp|O95487|SC24B_HUMAN",439,"O95487","SC24B_HUMAN","Protein transport protein Sec24B {ECO:0000305}",null,"SEC24B"]
["20.2455","20.2457","21.8671","21.1356",{"$nulls":3},"actin filament organization;adherens junction organization;aging;apical junction assembly;axon regeneration;cell adhesion;cellular protein localization;cellular response to indole-3-methanol;epithelial cell-cell adhesion;establishment or maintenance of cell polarity;gap junction assembly;male gonad development;negative regulation of cell motility;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;negative regulation of integrin-mediated signaling pathway;negative regulation of neuroblast proliferation;odontogenesis of dentin-containing tooth;ovarian follicle development;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;positive regulation of muscle cell differentiation;positive regulation of smoothened signaling pathway;protein heterooligomerization;response to estrogen","actin filament binding;beta-catenin binding;cadherin binding;gamma-catenin binding;identical protein binding;protein heterodimerization activity;RNA binding;structural molecule activity;vinculin binding","acrosomal vesicle;actin cytoskeleton;catenin complex;cell junction;cell-cell junction;cytosol;flotillin complex;focal adhesion;Golgi apparatus;intercalated disc;intracellular membrane-bounded organelle;lamellipodium;plasma membrane;zonula adherens","Adherens junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Endometrial cancer;Gastric cancer;Hippo signaling pathway;Leukocyte transendothelial migration;Pathways in cancer",null,null,24,24,18,"42.3","42.3","35.3","100.07",0,"222.84",1424500000,93,"1.12275","0.310212","-1.25574","-3.43305","sp|P35221|CTNA1_HUMAN;tr|G3XAM7|G3XAM7_HUMAN;tr|E5RGY7|E5RGY7_HUMAN;tr|A0A0A0MRI5|A0A0A0MRI5_HUMAN;tr|H0YBB8|H0YBB8_HUMAN;tr|E5RJ41|E5RJ41_HUMAN;tr|E5RIB1|E5RIB1_HUMAN;tr|A0A0A0MTJ6|A0A0A0MTJ6_HUMAN;tr|A0A087WZL6|A0A087WZL6_HUMAN;tr|E5RGU3|E5RGU3_HUMAN;tr|E5RHJ5|E5RHJ5_HUMAN;tr|E5RFG3|E5RFG3_HUMAN;tr|E5RFK9|E5RFK9_HUMAN;tr|E5RFM5|E5RFM5_HUMAN;tr|E5RJP7|E5RJP7_HUMAN;tr|E5RGD2|E5RGD2_HUMAN;tr|E5RGY6|E5RGY6_HUMAN;tr|E5RG03|E5RG03_HUMAN;tr|E5RGG4|E5RGG4_HUMAN;tr|E5RJ43|E5RJ43_HUMAN;tr|E5RGS1|E5RGS1_HUMAN;tr|E5RHV7|E5RHV7_HUMAN;tr|B9A010|B9A010_HUMAN;sp|Q9UI47|CTNA3_HUMAN","sp|P35221|CTNA1_HUMAN;tr|G3XAM7|G3XAM7_HUMAN",920,"P35221","CTNA1_HUMAN","Catenin alpha-1",null,"CTNNA1"]
["20.2731","19.9971","21.3148","21.4737",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},5,5,5,"36.9","36.9","36.9","16.714",0,"20.739",138650000,15,"1.80642","0.36811","-1.25911","-7.90819","tr|M0R3D6|M0R3D6_HUMAN;tr|M0R1A7|M0R1A7_HUMAN;tr|M0R117|M0R117_HUMAN;sp|Q02543|RL18A_HUMAN;tr|M0R0P7|M0R0P7_HUMAN","tr|M0R3D6|M0R3D6_HUMAN;tr|M0R1A7|M0R1A7_HUMAN;tr|M0R117|M0R117_HUMAN;sp|Q02543|RL18A_HUMAN;tr|M0R0P7|M0R0P7_HUMAN",1430,"M0R3D6","M0R3D6_HUMAN",null,null,"RPL18A"]
["18.8569","17.4743","19.7007","19.1659",{"$nulls":3},"chaperone cofactor-dependent protein refolding;protein folding;regulation of cellular response to heat","ATPase activator activity;heat shock protein binding","cytoplasm;cytoskeleton;cytosol;extracellular exosome;membrane;nucleoplasm",{"$nulls":3},6,6,6,17,17,17,"56.44",0,"15.667",234100000,15,"0.639531","0.405315","-1.26771","-1.71032","sp|Q99615|DNJC7_HUMAN;tr|K7ESP1|K7ESP1_HUMAN;tr|K7EPP7|K7EPP7_HUMAN;tr|K7EIH8|K7EIH8_HUMAN;tr|K7EJL5|K7EJL5_HUMAN;tr|K7EN19|K7EN19_HUMAN;tr|K7EJV7|K7EJV7_HUMAN;tr|K7ER44|K7ER44_HUMAN;tr|K7ELJ8|K7ELJ8_HUMAN;tr|K7EJE9|K7EJE9_HUMAN;tr|K7EK03|K7EK03_HUMAN;tr|K7EJ24|K7EJ24_HUMAN","sp|Q99615|DNJC7_HUMAN;tr|K7ESP1|K7ESP1_HUMAN;tr|K7EPP7|K7EPP7_HUMAN;tr|K7EIH8|K7EIH8_HUMAN;tr|K7EJL5|K7EJL5_HUMAN;tr|K7EN19|K7EN19_HUMAN;tr|K7EJV7|K7EJV7_HUMAN;tr|K7ER44|K7ER44_HUMAN",2389,"Q99615","DNJC7_HUMAN","DnaJ homolog subfamily C member 7",null,"DNAJC7"]
["15.3458","15.8574","17.7982","15.9445",{"$nulls":3},"actin cytoskeleton organization;apical constriction;bleb assembly;cortical actin cytoskeleton organization;ephrin receptor signaling pathway;execution phase of apoptosis;G-protein coupled receptor signaling pathway;I-kappaB kinase/NF-kappaB signaling;leukocyte cell-cell adhesion;leukocyte migration;leukocyte tethering or rolling;membrane to membrane docking;myoblast migration;negative regulation of angiogenesis;negative regulation of bicellular tight junction assembly;negative regulation of myosin-light-chain-phosphatase activity;negative regulation of neuron apoptotic process;negative regulation of protein binding;neutrophil degranulation;positive regulation of focal adhesion assembly;protein localization to plasma membrane;protein phosphorylation;regulation of actin cytoskeleton organization;regulation of cell adhesion;regulation of cell motility;regulation of establishment of cell polarity;regulation of establishment of endothelial barrier;regulation of focal adhesion assembly;regulation of keratinocyte differentiation;regulation of stress fiber assembly;Rho protein signal transduction;signal transduction;smooth muscle contraction;vascular endothelial growth factor receptor signaling pathway","ATP binding;GTP-Rho binding;metal ion binding;protein kinase activity;protein serine/threonine kinase activity","bleb;centriole;cytoskeleton;cytosol;extracellular region;Golgi membrane;lamellipodium;plasma membrane;ruffle;secretory granule lumen","Axon guidance;cAMP signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Focal adhesion;Human cytomegalovirus infection;Leukocyte transendothelial migration;MicroRNAs in cancer;Oxytocin signaling pathway;Pathogenic Escherichia coli infection;Pathways in cancer;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis;Sphingolipid signaling pathway;TGF-beta signaling pathway;Tight junction;Vascular smooth muscle contraction;Yersinia infection",null,null,7,6,6,"6.1","4.8","4.8","158.17",0,"20.597",114860000,15,"0.49827","0.513297","-1.26979","-1.32063","sp|Q13464|ROCK1_HUMAN;tr|J3KRH6|J3KRH6_HUMAN","sp|Q13464|ROCK1_HUMAN",1561,"Q13464","ROCK1_HUMAN","Rho-associated protein kinase 1",null,"ROCK1"]
["17.4902","18.9137","19.3632","19.5804",{"$nulls":4},"RNA binding",{"$nulls":4},1,1,1,"4.5","4.5","4.5","29.177",0,"13.061",58900000,11,"0.657894","0.390739","-1.26983","-1.76366","tr|D6R9H8|D6R9H8_HUMAN;tr|D6REB4|D6REB4_HUMAN;sp|Q9H074|PAIP1_HUMAN","tr|D6R9H8|D6R9H8_HUMAN;tr|D6REB4|D6REB4_HUMAN;sp|Q9H074|PAIP1_HUMAN",2549,"D6R9H8","D6R9H8_HUMAN",null,null,"PAIP1"]
["17.3154","17.9427","19.2817","18.5235",{"$nulls":3},"DNA damage response, detection of DNA damage;DNA repair;DNA replication;error-free translesion synthesis;error-prone translesion synthesis;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of DNA-directed DNA polymerase activity;regulation of signal transduction by p53 class mediator;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","ATP binding;DNA binding;enzyme binding","Ctf18 RFC-like complex;DNA replication factor C complex;nucleoplasm;nucleus","DNA replication;Mismatch repair;Nucleotide excision repair",null,null,2,2,2,"8.5","8.5","8.5","39.157",0,"4.9857",80755000,11,"0.912063","0.292994","-1.27357","-2.58836","sp|P35250|RFC2_HUMAN;tr|H7C5S7|H7C5S7_HUMAN;tr|H7C5P1|H7C5P1_HUMAN;tr|H7C5Q7|H7C5Q7_HUMAN;tr|F8WC37|F8WC37_HUMAN;tr|H7C5A0|H7C5A0_HUMAN;tr|H7C5G4|H7C5G4_HUMAN","sp|P35250|RFC2_HUMAN;tr|H7C5S7|H7C5S7_HUMAN;tr|H7C5P1|H7C5P1_HUMAN;tr|H7C5Q7|H7C5Q7_HUMAN;tr|F8WC37|F8WC37_HUMAN;tr|H7C5A0|H7C5A0_HUMAN;tr|H7C5G4|H7C5G4_HUMAN",926,"P35250","RFC2_HUMAN","Replication factor C subunit 2",null,"RFC2"]
["16.0394","19.4626","22.1218","15.9294",{"$nulls":3},"autophagic cell death;establishment of protein localization to organelle;Golgi to lysosome transport;granzyme-mediated apoptotic signaling pathway;neutrophil degranulation;positive regulation of natural killer cell degranulation;positive regulation of natural killer cell mediated cytotoxicity;protein stabilization;regulation of organelle transport along microtubule","enzyme binding;protein domain specific binding;virus receptor activity","alveolar lamellar body;autolysosome;azurophil granule membrane;cytolytic granule;cytoplasm;cytosol;dendrite;endosome membrane;external side of plasma membrane;extracellular exosome;ficolin-1-rich granule membrane;integral component of plasma membrane;late endosome;lysosomal membrane;lysosome;melanosome;membrane;multivesicular body;neuronal cell body;perinuclear region of cytoplasm;phagolysosome membrane;plasma membrane;sarcolemma;synaptic vesicle","Autophagy - animal;Lysosome;Phagosome;Tuberculosis",null,null,3,3,3,"9.8","9.8","9.8","44.882",0,"4.5705",307270000,6,"0.123132","0.902096","-1.27462","-0.360284","sp|P11279|LAMP1_HUMAN","sp|P11279|LAMP1_HUMAN",627,"P11279","LAMP1_HUMAN","Lysosome-associated membrane glycoprotein 1","AMP-1;ysosome-associated membrane protein 1","LAMP1"]
["18.289","18.7747","20.2294","19.3918",{"$nulls":3},"brain development;chemical synaptic transmission;cofactor metabolic process;cofactor transport;fatty-acyl-CoA biosynthetic process;lipid catabolic process;lysosomal lumen acidification;membrane raft organization;negative regulation of apoptotic process;negative regulation of cell growth;negative regulation of neuron apoptotic process;nervous system development;neuron development;pinocytosis;positive regulation of pinocytosis;positive regulation of receptor-mediated endocytosis;protein catabolic process;protein depalmitoylation;protein transport;receptor-mediated endocytosis;regulation of synapse structure or activity;response to stimulus;sphingolipid catabolic process;visual perception","palmitoyl-(protein) hydrolase activity;palmitoyl-CoA hydrolase activity","axon;cytosol;extracellular exosome;extracellular region;Golgi apparatus;lysosomal lumen;lysosome;membrane;membrane raft;nucleus;synaptic vesicle","Fatty acid elongation;Fatty acid metabolism;Lysosome;Metabolic pathways",null,null,2,2,2,"10.8","10.8","10.8","34.193",0,"18.212",78003000,8,"0.926614","0.296399","-1.27873","-2.64135","sp|P50897|PPT1_HUMAN;tr|E9PSE5|E9PSE5_HUMAN;tr|E9PP28|E9PP28_HUMAN;tr|E9PK48|E9PK48_HUMAN;tr|E9PIA8|E9PIA8_HUMAN;tr|E9PMG2|E9PMG2_HUMAN","sp|P50897|PPT1_HUMAN;tr|E9PSE5|E9PSE5_HUMAN;tr|E9PP28|E9PP28_HUMAN;tr|E9PK48|E9PK48_HUMAN;tr|E9PIA8|E9PIA8_HUMAN;tr|E9PMG2|E9PMG2_HUMAN",1122,"P50897","PPT1_HUMAN","Palmitoyl-protein thioesterase 1","PT-1","PPT1"]
["19.806","19.7387","21.5125","20.5941",{"$nulls":3},"DNA replication;dUMP biosynthetic process;dUTP catabolic process;liver development;nucleobase-containing compound metabolic process;nucleobase-containing small molecule interconversion;protein homotrimerization;regulation of protein heterodimerization activity;response to organic cyclic compound","dUTP diphosphatase activity;magnesium ion binding;peroxisome proliferator activated receptor binding;pyrimidine deoxyribonucleotide binding;receptor inhibitor activity;RNA binding","cytosol;extracellular exosome;mitochondrion;nucleoplasm;nucleus","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,6,6,4,"29.8","29.8","18.3","26.563",0,"41.027",307370000,44,"0.964372","0.293566","-1.28098","-2.78228","sp|P33316|DUT_HUMAN;tr|H0YNW5|H0YNW5_HUMAN;tr|A0A0C4DGL3|A0A0C4DGL3_HUMAN;tr|H0YKC5|H0YKC5_HUMAN;tr|H0YKI0|H0YKI0_HUMAN","sp|P33316|DUT_HUMAN;tr|H0YNW5|H0YNW5_HUMAN;tr|A0A0C4DGL3|A0A0C4DGL3_HUMAN;tr|H0YKC5|H0YKC5_HUMAN;tr|H0YKI0|H0YKI0_HUMAN",909,"P33316","DUT_HUMAN","Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial","UTPase","DUT"]
["20.2604","20.028","22.3515","20.5108",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of establishment of protein localization to mitochondrion;negative regulation of JUN kinase activity;negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;negative regulation of protein ubiquitination;positive regulation of apoptotic process;protein folding;protein localization to mitochondrion;regulation of protein transport;response to heat;response to unfolded protein","ATP binding;ATPase activator activity;C3HC4-type RING finger domain binding;chaperone binding;G-protein coupled receptor binding;Hsp70 protein binding;low-density lipoprotein particle receptor binding;metal ion binding;Tat protein binding;ubiquitin protein ligase binding;unfolded protein binding","cytoplasmic side of endoplasmic reticulum membrane;cytosol;extracellular exosome;membrane;microtubule cytoskeleton;mitochondrion;nucleus;perinuclear region of cytoplasm","Protein processing in endoplasmic reticulum",null,null,8,8,8,"28.7","28.7","28.7","44.868",0,"21.519",498580000,20,"0.523314","0.502074","-1.28701","-1.38738","sp|P31689|DNJA1_HUMAN","sp|P31689|DNJA1_HUMAN",888,"P31689","DNJA1_HUMAN","DnaJ homolog subfamily A member 1",null,"DNAJA1"]
["18.0416","18.013","19.555","19.0897",{"$nulls":9},1,1,1,"13.6","13.6","13.6","7.5737","0.0010842","2.4927",24413000,5,"1.50999","0.321207","-1.29503","-5.55573","tr|H3BUR4|H3BUR4_HUMAN;sp|Q9ULX3|NOB1_HUMAN","tr|H3BUR4|H3BUR4_HUMAN;sp|Q9ULX3|NOB1_HUMAN",2898,"H3BUR4","H3BUR4_HUMAN",null,null,"NOB1"]
["16.9573","17.7619","18.7979","18.5122",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding",{"$nulls":4},8,5,5,"15.6","14.2","14.2","69.086",0,"40.306",112640000,12,"1.02874","0.298053","-1.29548","-3.03459","tr|J3KTA4|J3KTA4_HUMAN;sp|P17844|DDX5_HUMAN;tr|J3QRQ7|J3QRQ7_HUMAN;tr|J3QR02|J3QR02_HUMAN;tr|J3KRX8|J3KRX8_HUMAN;tr|J3QSF1|J3QSF1_HUMAN;tr|J3KRZ1|J3KRZ1_HUMAN;tr|J3QLG9|J3QLG9_HUMAN;tr|J3QR62|J3QR62_HUMAN;tr|J3QRN5|J3QRN5_HUMAN;tr|X6RLV5|X6RLV5_HUMAN","tr|J3KTA4|J3KTA4_HUMAN;sp|P17844|DDX5_HUMAN",712,"J3KTA4","J3KTA4_HUMAN",null,null,"DDX5"]
["18.2292","17.7851","19.8924","18.7277",{"$nulls":9},2,2,2,"18.6","18.6","18.6","15.376",0,"3.7998",49822000,4,"0.765175","0.33827","-1.30287","-2.09054","tr|A0A096LPC8|A0A096LPC8_HUMAN;sp|Q96SU4|OSBL9_HUMAN","tr|A0A096LPC8|A0A096LPC8_HUMAN;sp|Q96SU4|OSBL9_HUMAN",2357,"A0A096LPC8","A0A096LPC8_HUMAN",null,null,"OSBPL9"]
["18.3218","18.0702","19.7327","19.2709",{"$nulls":3},"mitochondrial respiratory chain complex I assembly",null,"integral component of membrane;mitochondrial inner membrane",{"$nulls":3},1,1,1,"18.1","18.1","18.1","12.257","0.0050471","1.9205",16873000,6,"1.41764","0.332916","-1.30583","-4.96687","sp|Q96GE9|TM261_HUMAN","sp|Q96GE9|TM261_HUMAN",2279,"Q96GE9","DMAC1_HUMAN","Distal membrane-arm assembly complex protein 1 {ECO:0000303|PubMed:27626371}",null,"DMAC1"]
[1,"12.8991","15.5281",1,{"$nulls":9},3,3,3,"3.3","3.3","3.3","122.96",0,"13.998",31794000,6,"0.0450402","0.955948","-1.31452","-0.139999","tr|A0A0A0MTG4|A0A0A0MTG4_HUMAN;sp|P82094|TMF1_HUMAN;tr|F8WF45|F8WF45_HUMAN","tr|A0A0A0MTG4|A0A0A0MTG4_HUMAN;sp|P82094|TMF1_HUMAN;tr|F8WF45|F8WF45_HUMAN",1376,"A0A0A0MTG4"]
["24.2523","24.1066","25.4631","25.5461",{"$nulls":3},"amino acid transport;glutamine secretion;glutamine transport;L-glutamine import across plasma membrane;neutral amino acid transport","amino acid transmembrane transporter activity;L-glutamine transmembrane transporter activity;L-serine transmembrane transporter activity;neutral amino acid transmembrane transporter activity;receptor activity;symporter activity;virus receptor activity","extracellular exosome;integral component of plasma membrane;melanosome;membrane;plasma membrane","Central carbon metabolism in cancer;Protein digestion and absorption",null,null,10,10,10,"21.3","21.3","21.3","56.598",0,"292.71",3854200000,58,"2.40034","0.474872","-1.32515","-15.8077","sp|Q15758|AAAT_HUMAN;tr|M0QXM4|M0QXM4_HUMAN;tr|M0QX44|M0QX44_HUMAN","sp|Q15758|AAAT_HUMAN;tr|M0QXM4|M0QXM4_HUMAN",1720,"Q15758","AAAT_HUMAN","Neutral amino acid transporter B(0)","TB(0)","SLC1A5"]
["15.8359","15.2331","16.9386","16.7819",{"$nulls":3},"attachment of mitotic spindle microtubules to kinetochore;attachment of spindle microtubules to kinetochore;cell division;chromosome segregation;establishment of mitotic spindle orientation;kinetochore organization;metaphase plate congression;mitotic cell cycle;mitotic sister chromatid segregation;mitotic spindle organization;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of protein localization to kinetochore;sister chromatid cohesion","identical protein binding;structural constituent of cytoskeleton","centrosome;chromosome, centromeric region;condensed chromosome kinetochore;condensed nuclear chromosome outer kinetochore;cytosol;kinetochore;membrane;Ndc80 complex;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"4.8","4.8","4.8","73.912",0,"6.9677",57287000,8,"1.2925","0.333213","-1.32578","-4.25724","sp|O14777|NDC80_HUMAN;tr|I3L4G3|I3L4G3_HUMAN","sp|O14777|NDC80_HUMAN",174,"O14777","NDC80_HUMAN","Kinetochore protein NDC80 homolog",null,"NDC80"]
["19.7924","18.9025","20.9578","20.3913",{"$nulls":4},"ATP binding",{"$nulls":4},3,3,3,"34.1","34.1","34.1","13.34",0,"12.801",105330000,11,"0.891839","0.299924","-1.32711","-2.51589","tr|C9JXZ7|C9JXZ7_HUMAN;tr|C9JTT7|C9JTT7_HUMAN;tr|C9J8M3|C9J8M3_HUMAN;tr|C9JZI1|C9JZI1_HUMAN;sp|P35249|RFC4_HUMAN;tr|C9JGY5|C9JGY5_HUMAN;tr|F8WE44|F8WE44_HUMAN;tr|C9JW34|C9JW34_HUMAN","tr|C9JXZ7|C9JXZ7_HUMAN;tr|C9JTT7|C9JTT7_HUMAN;tr|C9J8M3|C9J8M3_HUMAN;tr|C9JZI1|C9JZI1_HUMAN;sp|P35249|RFC4_HUMAN;tr|C9JGY5|C9JGY5_HUMAN;tr|F8WE44|F8WE44_HUMAN",925,"C9JXZ7","C9JXZ7_HUMAN",null,null,"RFC4"]
["18.3293","18.2452","19.7182","19.5106",{"$nulls":3},"cell division;meiotic chromosome condensation;meiotic chromosome segregation;mitotic chromosome condensation","chromatin binding;DNA topoisomerase (ATP-hydrolyzing) activator activity;DNA topoisomerase binding","condensin complex;cytosol;membrane;nuclear condensin complex;nucleus",{"$nulls":3},10,10,10,"17.1","17.1","17.1","82.562",0,"22.618",269580000,21,"2.15173","0.41502","-1.32714","-11.8456","sp|Q15003|CND2_HUMAN;tr|E9PHA2|E9PHA2_HUMAN;tr|C9J470|C9J470_HUMAN;tr|C9JZP1|C9JZP1_HUMAN;tr|H7C415|H7C415_HUMAN","sp|Q15003|CND2_HUMAN;tr|E9PHA2|E9PHA2_HUMAN;tr|C9J470|C9J470_HUMAN",1655,"Q15003","CND2_HUMAN","Condensin complex subunit 2",null,"NCAPH"]
["22.5891","22.5832","23.9791","23.8479",{"$nulls":3},"adherens junction assembly;androgen receptor signaling pathway;anterior/posterior axis specification;beta-catenin destruction complex disassembly;beta-catenin-TCF complex assembly;bone resorption;branching involved in blood vessel morphogenesis;branching involved in ureteric bud morphogenesis;canonical Wnt signaling pathway;canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;canonical Wnt signaling pathway involved in negative regulation of apoptotic process;canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation;canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition;catenin import into nucleus;cell adhesion;cell fate specification;cell maturation;cell morphogenesis involved in differentiation;cell-cell adhesion;cell-matrix adhesion;cellular response to growth factor stimulus;cellular response to indole-3-methanol;central nervous system vasculogenesis;chemical synaptic transmission;chromatin-mediated maintenance of transcription;cranial ganglion development;cranial skeletal system development;dorsal root ganglion development;dorsal/ventral axis specification;ectoderm development;embryonic axis specification;embryonic brain development;embryonic digit morphogenesis;embryonic foregut morphogenesis;embryonic forelimb morphogenesis;embryonic heart tube development;embryonic hindlimb morphogenesis;embryonic skeletal limb joint morphogenesis;endodermal cell fate commitment;endothelial tube morphogenesis;entry of bacterium into host cell;epithelial cell differentiation involved in prostate gland development;epithelial to mesenchymal transition;epithelial tube branching involved in lung morphogenesis;fungiform papilla formation;gastrulation with mouth forming second;genitalia morphogenesis;glial cell fate determination;hair cell differentiation;hair follicle morphogenesis;hair follicle placode formation;hindbrain development;in utero embryonic development;layer formation in cerebral cortex;lens morphogenesis in camera-type eye;lung cell differentiation;lung induction;lung-associated mesenchyme development;male genitalia development;mesenchymal cell proliferation involved in lung development;metanephros morphogenesis;midbrain dopaminergic neuron differentiation;negative regulation of angiogenesis;negative regulation of apoptotic signaling pathway;negative regulation of cell death;negative regulation of cell proliferation;negative regulation of chondrocyte differentiation;negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;negative regulation of mitotic cell cycle, embryonic;negative regulation of oligodendrocyte differentiation;negative regulation of osteoclast differentiation;negative regulation of oxidative stress-induced neuron death;negative regulation of protein sumoylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;nephron tubule formation;neural plate development;neuron migration;neuron projection extension;odontogenesis of dentin-containing tooth;oocyte development;osteoclast differentiation;oviduct development;pancreas development;positive regulation of apoptotic process;positive regulation of chromatin-mediated maintenance of transcription;positive regulation of core promoter binding;positive regulation of determination of dorsal identity;positive regulation of DNA binding transcription factor activity;positive regulation of DNA-templated transcription, initiation;positive regulation of endothelial cell differentiation;positive regulation of epithelial cell proliferation involved in prostate gland development;positive regulation of epithelial to mesenchymal transition;positive regulation of fibroblast growth factor receptor signaling pathway;positive regulation of heparan sulfate proteoglycan biosynthetic process;positive regulation of histone H3-K4 methylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of MAPK cascade;positive regulation of mesenchymal cell proliferation;positive regulation of muscle cell differentiation;positive regulation of neuroblast proliferation;positive regulation of neuron apoptotic process;positive regulation of osteoblast differentiation;positive regulation of skeletal muscle tissue development;positive regulation of telomerase activity;positive regulation of telomere maintenance via telomerase;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;proteasome-mediated ubiquitin-dependent protein catabolic process;protein localization to cell surface;proximal/distal pattern formation;regulation of angiogenesis;regulation of calcium ion import;regulation of centriole-centriole cohesion;regulation of centromeric sister chromatid cohesion;regulation of euchromatin binding;regulation of fibroblast proliferation;regulation of myelination;regulation of nephron tubule epithelial cell differentiation;regulation of neurogenesis;regulation of protein localization to cell surface;regulation of secondary heart field cardioblast proliferation;regulation of smooth muscle cell proliferation;regulation of T cell proliferation;regulation of timing of anagen;renal inner medulla development;renal outer medulla development;renal vesicle formation;response to drug;response to estradiol;smooth muscle cell differentiation;stem cell population maintenance;sympathetic ganglion development;synapse organization;synaptic vesicle transport;T cell differentiation in thymus;thymus development;trachea formation;transcription, DNA-templated;Wnt signaling pathway;Wnt signaling pathway, calcium modulating pathway","alpha-catenin binding;androgen receptor binding;cadherin binding;chromatin binding;disordered domain specific binding;DNA binding transcription factor activity;enzyme binding;estrogen receptor binding;ion channel binding;I-SMAD binding;kinase binding;nuclear hormone receptor binding;protein C-terminus binding;protein heterodimerization activity;protein kinase binding;protein phosphatase binding;repressing transcription factor binding;RNA polymerase II activating transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription factor binding;signal transducer activity;SMAD binding;transcription coactivator activity;transcription factor binding;transcription regulatory region DNA binding","adherens junction;apical part of cell;basolateral plasma membrane;beta-catenin destruction complex;beta-catenin-TCF complex;beta-catenin-TCF7L2 complex;bicellular tight junction;catenin complex;cell cortex;cell junction;cell periphery;cell-cell adherens junction;cell-cell junction;centrosome;cytoplasm;cytosol;extracellular exosome;fascia adherens;flotillin complex;focal adhesion;intracellular;lamellipodium;lateral plasma membrane;membrane;microvillus membrane;nuclear euchromatin;nucleoplasm;nucleus;perinuclear region of cytoplasm;plasma membrane;protein complex;protein-DNA complex;Scrib-APC-beta-catenin complex;spindle pole;synapse;transcription factor complex;Wnt signalosome;Z disc","Adherens junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Basal cell carcinoma;Breast cancer;Colorectal cancer;Cushing syndrome;Endometrial cancer;Fluid shear stress and atherosclerosis;Focal adhesion;Gastric cancer;Hepatitis C;Hepatocellular carcinoma;Hippo signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Melanogenesis;Pathogenic Escherichia coli infection;Pathways in cancer;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Signaling pathways regulating pluripotency of stem cells;Thyroid cancer;Thyroid hormone signaling pathway;Wnt signaling pathway",null,null,20,20,19,"41.2","41.2","39.6","85.496",0,"323.31",6085100000,156,"2.61251","0.565161","-1.32731","-20.205","sp|P35222|CTNB1_HUMAN;tr|B4DGU4|B4DGU4_HUMAN;tr|E7EMJ5|E7EMJ5_HUMAN;tr|E9PDF9|E9PDF9_HUMAN;tr|E7EV28|E7EV28_HUMAN;tr|C9IZ65|C9IZ65_HUMAN","sp|P35222|CTNB1_HUMAN;tr|B4DGU4|B4DGU4_HUMAN",921,"P35222","CTNB1_HUMAN","Catenin beta-1",null,"CTNNB1"]
["15.3937","14.3113","16.8912","15.469",{"$nulls":4},"ATP binding",{"$nulls":4},3,3,3,"4.2","4.2","4.2","126.98",0,"18.007",35463000,9,"0.559589","0.470905","-1.32761","-1.48569","tr|B5MDQ0|B5MDQ0_HUMAN;sp|Q2NKX8|ERC6L_HUMAN","tr|B5MDQ0|B5MDQ0_HUMAN;sp|Q2NKX8|ERC6L_HUMAN",1771,"B5MDQ0","B5MDQ0_HUMAN",null,null,"ERCC6L"]
["16.4847","16.2079","18.6693","16.6869",{"$nulls":3},"nucleotide metabolic process","5'-nucleotidase activity;magnesium ion binding;nucleotide binding","cytoplasm",{"$nulls":3},2,2,2,"7.6","7.6","7.6","37.405",0,"3.7882",26796000,9,"0.502075","0.513171","-1.33183","-1.33071","tr|X6RM59|X6RM59_HUMAN;sp|Q9H0P0|5NT3A_HUMAN","tr|X6RM59|X6RM59_HUMAN;sp|Q9H0P0|5NT3A_HUMAN",2561,"X6RM59","X6RM59_HUMAN","5'-nucleotidase {ECO:0000256|RuleBase:RU361276}",null,"NT5C3A"]
["17.0045","16.4658","18.428","17.7062",{"$nulls":3},"signal transduction","GTPase activator activity",{"$nulls":4},4,4,4,"6.8","6.8","6.8","90.873",0,"24.716",92749000,6,"1.00955","0.296585","-1.33192","-2.95773","tr|Q1RLN5|Q1RLN5_HUMAN;sp|Q8IWW6|RHG12_HUMAN;tr|H0Y5D8|H0Y5D8_HUMAN","tr|Q1RLN5|Q1RLN5_HUMAN;sp|Q8IWW6|RHG12_HUMAN",2017,"Q1RLN5","Q1RLN5_HUMAN"]
["18.4644","18.0484","19.5727","19.6245",{"$nulls":9},1,1,1,"37.9","37.9","37.9","11.246",0,"33.738",21819000,1,"1.62829","0.325915","-1.3422","-6.40282","tr|K7EJQ6|K7EJQ6_HUMAN;tr|K7ERQ0|K7ERQ0_HUMAN;tr|K7ERY2|K7ERY2_HUMAN;tr|K7EPQ7|K7EPQ7_HUMAN;sp|Q5BJH7|YIF1B_HUMAN","tr|K7EJQ6|K7EJQ6_HUMAN;tr|K7ERQ0|K7ERQ0_HUMAN;tr|K7ERY2|K7ERY2_HUMAN;tr|K7EPQ7|K7EPQ7_HUMAN;sp|Q5BJH7|YIF1B_HUMAN",1803,"K7EJQ6","K7EJQ6_HUMAN",null,null,"YIF1B"]
["15.3689","16.422","17.3336","17.1432",{"$nulls":3},"one-carbon metabolic process","adenosylhomocysteinase activity",{"$nulls":4},1,1,1,"2.3","2.3","2.3","58.004",0,"3.9795",23698000,4,"0.890141","0.299051","-1.34295","-2.50986","tr|H0Y8B3|H0Y8B3_HUMAN;sp|O43865|SAHH2_HUMAN;sp|Q96HN2|SAHH3_HUMAN","tr|H0Y8B3|H0Y8B3_HUMAN;sp|O43865|SAHH2_HUMAN;sp|Q96HN2|SAHH3_HUMAN",274,"H0Y8B3","H0Y8B3_HUMAN","Adenosylhomocysteinase {ECO:0000256|RuleBase:RU000548}",null,"AHCYL2"]
["18.9137","17.2266","19.7644","19.0691",{"$nulls":9},3,3,3,"8.9","8.9","8.9","41.155",0,"8.332",139100000,4,"0.556042","0.471486","-1.34665","-1.47599","tr|E9PCJ7|E9PCJ7_HUMAN;sp|Q8N806|UBR7_HUMAN;tr|G3V336|G3V336_HUMAN;tr|H0YJY4|H0YJY4_HUMAN;tr|H0YJM2|H0YJM2_HUMAN","tr|E9PCJ7|E9PCJ7_HUMAN;sp|Q8N806|UBR7_HUMAN;tr|G3V336|G3V336_HUMAN",2065,"E9PCJ7","E9PCJ7_HUMAN",null,null,"UBR7"]
["12.6321","15.0862","15.726","14.705",{"$nulls":3},"immunoglobulin biosynthetic process;O-glycan processing;protein O-linked glycosylation;protein O-linked glycosylation via serine;protein O-linked glycosylation via threonine","carbohydrate binding;manganese ion binding;polypeptide N-acetylgalactosaminyltransferase activity","endoplasmic reticulum membrane;extracellular exosome;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;Golgi stack;integral component of Golgi membrane;membrane;perinuclear region of cytoplasm","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,1,1,1,"3.5","3.5","3.5","64.732",0,"9.4695",9910100,3,"0.382155","0.638767","-1.35638","-1.02059","sp|Q10471|GALT2_HUMAN","sp|Q10471|GALT2_HUMAN",1486,"Q10471","GALT2_HUMAN","Polypeptide N-acetylgalactosaminyltransferase 2",null,"GALNT2"]
["20.7103","20.3036","21.9661","21.7655",{"$nulls":3},"mitochondrion organization;positive regulation of transcription from RNA polymerase II promoter;regulation of cellular response to hypoxia;transcription, DNA-templated","sequence-specific DNA binding;transcription factor binding","mitochondrial intermembrane space;mitochondrion;nucleus",{"$nulls":3},3,3,3,"27.2","27.2","27.2","15.512",0,"30.766",134650000,12,"1.57302","0.329739","-1.35883","-5.99327","sp|Q9Y6H1|CHCH2_HUMAN;sp|Q5T1J5|CHCH9_HUMAN","sp|Q9Y6H1|CHCH2_HUMAN;sp|Q5T1J5|CHCH9_HUMAN",1829,"Q9Y6H1","CHCH2_HUMAN","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2",null,"CHCHD2"]
["15.4714","15.5137","16.6011","17.1089",{"$nulls":3},"hair follicle maturation;neurogenesis;ribosomal small subunit biogenesis","RNA binding","nucleolus;nucleus",{"$nulls":3},1,1,1,"1.5","1.5","1.5","96.256",0,"22.755",30367000,9,"1.47836","0.328797","-1.36244","-5.34733","sp|Q5C9Z4|NOM1_HUMAN","sp|Q5C9Z4|NOM1_HUMAN",1804,"Q5C9Z4","NOM1_HUMAN","Nucleolar MIF4G domain-containing protein 1",null,"NOM1"]
["23.7117","21.8852","24.6583","23.6688",{"$nulls":3},"positive regulation of transcription initiation from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter;SMAD protein signal transduction","identical protein binding;RNA binding;single-stranded DNA binding;transcription coactivator activity;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding","extracellular exosome;nucleolus;nucleus;transcription factor complex",{"$nulls":3},3,3,3,"33.9","33.9","33.9","14.395",0,"11.211",619780000,8,"0.495897","0.51722","-1.36512","-1.31435","sp|P53999|TCP4_HUMAN;tr|D6RC37|D6RC37_HUMAN;tr|D6R970|D6R970_HUMAN","sp|P53999|TCP4_HUMAN",1187,"P53999","TCP4_HUMAN","Activated RNA polymerase II transcriptional coactivator p15",null,"SUB1"]
["17.7653","17.4368","19.0504","18.8822",{"$nulls":3},"folic acid metabolic process;one-carbon metabolic process;tetrahydrofolate metabolic process","magnesium ion binding;methenyltetrahydrofolate cyclohydrolase activity;methylenetetrahydrofolate dehydrogenase (NAD+) activity;methylenetetrahydrofolate dehydrogenase (NADP+) activity;phosphate ion binding","extracellular space;mitochondrial matrix;mitochondrion","Metabolic pathways;One carbon pool by folate",null,null,4,4,4,18,18,18,"37.895",0,"4.8743",103130000,12,"1.75009","0.352713","-1.36528","-7.39933","sp|P13995|MTDC_HUMAN;tr|B9A062|B9A062_HUMAN","sp|P13995|MTDC_HUMAN",666,"P13995","MTDC_HUMAN","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial",null,"MTHFD2"]
["17.9281","17.5842","19.1092","19.1352",{"$nulls":3},"exocyst localization;Golgi to plasma membrane transport;negative regulation of exocytosis;regulation of SNARE complex assembly","cadherin binding involved in cell-cell adhesion;GTP-Rho binding;phosphatidylinositol-4,5-bisphosphate binding","cell-cell adherens junction;exocyst;integral component of membrane;plasma membrane",{"$nulls":3},1,1,1,"5.7","5.7","5.7","23.554",0,"9.0569",71411000,2,"1.80795","0.370648","-1.366","-7.92249","sp|Q8NFX7|STXB6_HUMAN","sp|Q8NFX7|STXB6_HUMAN",2099,"Q8NFX7","STXB6_HUMAN","Syntaxin-binding protein 6",null,"STXBP6"]
["15.0316","15.3836","16.8084","16.341",{"$nulls":4},"GTPase activator activity",{"$nulls":4},1,1,1,3,3,3,"43.347",0,"6.4098",11190000,1,"1.3679","0.333256","-1.36711","-4.67337","tr|H0Y873|H0Y873_HUMAN;sp|Q96P47|AGAP3_HUMAN","tr|H0Y873|H0Y873_HUMAN;sp|Q96P47|AGAP3_HUMAN",2331,"H0Y873","H0Y873_HUMAN",null,null,"AGAP3"]
[1,"15.0093","17.7482",1,{"$nulls":3},"circadian rhythm;mRNA destabilization;mRNA processing;mRNA splicing, via spliceosome;negative regulation of catalytic activity;RNA metabolic process","mRNA 3'-UTR binding;RNA binding","axon terminus;catalytic step 2 spliceosome;dendrite;endoplasmic reticulum;growth cone;intracellular ribonucleoprotein complex;nucleoplasm;spliceosomal complex",{"$nulls":3},3,2,2,"6.3","4.4","4.4","70.942",0,"4.322",8606800,1,"0.0401726","0.956516","-1.36947","-0.125439","sp|O43390|HNRPR_HUMAN;tr|B4DT28|B4DT28_HUMAN","sp|O43390|HNRPR_HUMAN",244,"O43390","HNRPR_HUMAN","Heterogeneous nuclear ribonucleoprotein R","nRNP R","HNRNPR"]
["21.309","20.1454","22.1139","22.0859",{"$nulls":3},"'de novo' pyrimidine nucleobase biosynthetic process;nucleobase-containing small molecule interconversion;nucleoside diphosphate phosphorylation;nucleoside triphosphate biosynthetic process;pyrimidine ribonucleotide biosynthetic process","ATP binding;cytidylate kinase activity;nucleoside diphosphate kinase activity;nucleoside phosphate kinase activity;uridine kinase activity;uridylate kinase activity","cytoplasm;cytosol;extracellular exosome;nucleolus;nucleus","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,7,7,7,"37.8","37.8","37.8","22.222",0,"47.201",327570000,35,"0.846657","0.309528","-1.37267","-2.35871","sp|P30085|KCY_HUMAN;tr|Q5T0D2|Q5T0D2_HUMAN;tr|E9PJD2|E9PJD2_HUMAN","sp|P30085|KCY_HUMAN;tr|Q5T0D2|Q5T0D2_HUMAN",863,"P30085","KCY_HUMAN","UMP-CMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}",null,"CMPK1"]
["17.002","16.7798","17.9738","18.5564",{"$nulls":4},"cadherin binding;identical protein binding","cytoplasm;cytosol;nucleoplasm","Endocytosis",null,null,3,3,3,"10.1","10.1","10.1","43.973",0,"12.182",53716000,5,"1.32046","0.333741","-1.3742","-4.40763","sp|Q9NR46|SHLB2_HUMAN;tr|B7ZC38|B7ZC38_HUMAN;tr|B7ZC39|B7ZC39_HUMAN;tr|F8WFB9|F8WFB9_HUMAN","sp|Q9NR46|SHLB2_HUMAN;tr|B7ZC38|B7ZC38_HUMAN;tr|B7ZC39|B7ZC39_HUMAN",2680,"Q9NR46","SHLB2_HUMAN","Endophilin-B2",null,"SH3GLB2"]
["18.2588","18.5925","19.5177","20.1011",{"$nulls":3},"ATP-dependent chromatin remodeling;behavioral response to ethanol;blood coagulation;cardiac muscle hypertrophy;cellular response to dopamine;cellular response to heat;cellular response to hydrogen peroxide;cellular response to retinoic acid;cellular response to transforming growth factor beta stimulus;chromatin remodeling;circadian regulation of gene expression;dendrite development;embryonic digit morphogenesis;epidermal cell differentiation;eyelid development in camera-type eye;fungiform papilla formation;hair follicle placode formation;histone deacetylation;histone H3 deacetylation;histone H4 deacetylation;maintenance of chromatin silencing;negative regulation of apoptotic process;negative regulation of dendritic spine development;negative regulation of DNA binding;negative regulation of DNA binding transcription factor activity;negative regulation of MHC class II biosynthetic process;negative regulation of neuron projection development;negative regulation of peptidyl-lysine acetylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;odontogenesis of dentin-containing tooth;positive regulation of cell proliferation;positive regulation of collagen biosynthetic process;positive regulation of epithelial to mesenchymal transition;positive regulation of interleukin-1 production;positive regulation of oligodendrocyte differentiation;positive regulation of proteolysis;positive regulation of receptor biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of tumor necrosis factor production;positive regulation of tyrosine phosphorylation of STAT protein;regulation of signal transduction by p53 class mediator;response to amphetamine;response to caffeine;response to cocaine;response to drug;response to hyperoxia;response to lipopolysaccharide;response to nicotine;transcription, DNA-templated","chromatin binding;core promoter binding;deacetylase activity;enzyme binding;heat shock protein binding;histone deacetylase activity;histone deacetylase binding;NAD-dependent histone deacetylase activity (H3-K14 specific);NF-kappaB binding;protein deacetylase activity;RNA binding;RNA polymerase II repressing transcription factor binding;sequence-specific DNA binding;transcription factor binding","cytoplasm;ESC/E(Z) complex;nuclear chromatin;nucleoplasm;nucleus;NuRD complex;protein complex;Sin3 complex","Alcoholism;Cell cycle;Chronic myeloid leukemia;Epstein-Barr virus infection;Human papillomavirus infection;Huntington disease;Longevity regulating pathway - multiple species;Notch signaling pathway;Pathways in cancer;Thyroid hormone signaling pathway;Transcriptional misregulation in cancer;Viral carcinogenesis",null,null,3,3,1,"8.8","8.8","3.9","55.364",0,"29.318",162340000,7,"1.2658","0.326332","-1.38379","-4.11773","sp|Q92769|HDAC2_HUMAN;tr|Q5TEE2|Q5TEE2_HUMAN;tr|E5RFI6|E5RFI6_HUMAN;tr|E5RJ04|E5RJ04_HUMAN;tr|E5RGV4|E5RGV4_HUMAN;tr|E5RHE7|E5RHE7_HUMAN;tr|E5RH52|E5RH52_HUMAN;tr|E5RG37|E5RG37_HUMAN;tr|E5RFP9|E5RFP9_HUMAN;tr|H3BM24|H3BM24_HUMAN","sp|Q92769|HDAC2_HUMAN;tr|Q5TEE2|Q5TEE2_HUMAN",2189,"Q92769","HDAC2_HUMAN","Histone deacetylase 2","D2","HDAC2"]
["19.5298","20.3678","21.5606","21.1187",{"$nulls":9},2,2,2,"18.3","18.3","18.3","18.356",0,"41.704",188810000,11,"1.00407","0.294801","-1.39086","-2.93601","tr|M0R389|M0R389_HUMAN;sp|Q15102|PA1B3_HUMAN;tr|M0QXS6|M0QXS6_HUMAN;tr|M0R323|M0R323_HUMAN;tr|M0QZT2|M0QZT2_HUMAN","tr|M0R389|M0R389_HUMAN;sp|Q15102|PA1B3_HUMAN;tr|M0QXS6|M0QXS6_HUMAN;tr|M0R323|M0R323_HUMAN;tr|M0QZT2|M0QZT2_HUMAN",1676,"M0R389","M0R389_HUMAN",null,null,"PAFAH1B3"]
["17.214","17.783","19.2492","18.5404",{"$nulls":3},"cell proliferation;cellular response to cytokine stimulus;DNA repair;negative regulation of cell cycle arrest;negative regulation of mRNA polyadenylation;phosphorylation of RNA polymerase II C-terminal domain;positive regulation of cardiac muscle hypertrophy;positive regulation of histone H2B ubiquitination;positive regulation of histone phosphorylation;positive regulation of mRNA 3'-UTR binding;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral transcription;protein phosphorylation;regulation of DNA repair;regulation of histone modification;regulation of muscle cell differentiation;replication fork processing;response to drug;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","7SK snRNA binding;ATP binding;chromatin binding;cyclin binding;cyclin-dependent protein serine/threonine kinase activity;DNA binding;kinase activity;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity;RNA polymerase II core promoter sequence-specific DNA binding;transcription coactivator binding;transcription regulatory region DNA binding","chromosome;cyclin/CDK positive transcription elongation factor complex;cytoplasmic ribonucleoprotein granule;membrane;nucleoplasm;PML body;transcription elongation factor complex","Transcriptional misregulation in cancer",null,null,1,1,1,"3.2","3.2","3.2","42.777",0,"51.705",71483000,10,"1.03802","0.299062","-1.39627","-3.07227","sp|P50750|CDK9_HUMAN","sp|P50750|CDK9_HUMAN",1120,"P50750","CDK9_HUMAN","Cyclin-dependent kinase 9",null,"CDK9"]
["15.0946","15.4341","17.1449","16.1833",{"$nulls":4},"receptor activity","integral component of membrane",{"$nulls":3},1,1,1,"8.9","8.9","8.9","22.209",0,"3.6942",11336000,3,"0.954543","0.29846","-1.39974","-2.74511","tr|H7C240|H7C240_HUMAN;tr|H7C3E1|H7C3E1_HUMAN;sp|O75787|RENR_HUMAN","tr|H7C240|H7C240_HUMAN;tr|H7C3E1|H7C3E1_HUMAN;sp|O75787|RENR_HUMAN",365,"H7C240","H7C240_HUMAN",null,null,"ATP6AP2"]
["15.9981","15.3449","17.2856","16.8704",{"$nulls":3},"DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;gene silencing by miRNA;multicellular organism development;negative regulation of intracellular estrogen receptor signaling pathway;negative regulation of retinoic acid receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of translation;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of cytoplasmic mRNA processing body assembly;positive regulation of mRNA catabolic process;positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;regulation of stem cell population maintenance;RNA phosphodiester bond hydrolysis, exonucleolytic;transcription, DNA-templated","armadillo repeat domain binding;estrogen receptor binding;protein complex scaffold activity;protein domain specific binding;retinoic acid receptor binding;RNA binding","CCR4-NOT complex;CCR4-NOT core complex;cytosol;extracellular space;membrane;nucleus;P-body;peroxisomal membrane","RNA degradation",null,null,7,7,7,"4.4","4.4","4.4","266.94",0,"18.214",139460000,22,"1.16706","0.31761","-1.40656","-3.63439","sp|A5YKK6|CNOT1_HUMAN;tr|H3BR89|H3BR89_HUMAN;tr|H3BMH0|H3BMH0_HUMAN;tr|H3BMZ2|H3BMZ2_HUMAN","sp|A5YKK6|CNOT1_HUMAN",101,"A5YKK6","CNOT1_HUMAN","CCR4-NOT transcription complex subunit 1",null,"CNOT1"]
["16.9635","17.6917","19.1869","18.3006",{"$nulls":4},"protein serine/threonine phosphatase activity;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity","cytosol;nucleus",{"$nulls":3},5,5,5,"8.5","8.5","8.5","96.753",0,"39.869",148900000,16,"0.878563","0.302029","-1.41614","-2.46903","sp|Q9ULE6|PALD_HUMAN","sp|Q9ULE6|PALD_HUMAN",2890,"Q9ULE6","PALD_HUMAN","Paladin",null,"PALD1"]
["15.5562","14.7182","16.8534","16.2547",{"$nulls":3},"small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity","intracellular",{"$nulls":3},6,6,5,"4.7","4.7","4.2","240.34",0,"9.852",71332000,19,"0.956253","0.297645","-1.41688","-2.75155","tr|A0A0A0MSY4|A0A0A0MSY4_HUMAN;sp|Q9BZ29|DOCK9_HUMAN;tr|A0A088AWN3|A0A088AWN3_HUMAN;tr|A0A0A0MRA7|A0A0A0MRA7_HUMAN;tr|H0Y3S1|H0Y3S1_HUMAN;tr|A0A0A0MT38|A0A0A0MT38_HUMAN;tr|X6RGR3|X6RGR3_HUMAN;tr|H7BZ79|H7BZ79_HUMAN;tr|Q5JUD8|Q5JUD8_HUMAN;tr|A0A0D9SFH5|A0A0D9SFH5_HUMAN;tr|A0A0J9YW64|A0A0J9YW64_HUMAN","tr|A0A0A0MSY4|A0A0A0MSY4_HUMAN;sp|Q9BZ29|DOCK9_HUMAN;tr|A0A088AWN3|A0A088AWN3_HUMAN;tr|A0A0A0MRA7|A0A0A0MRA7_HUMAN",3064,"A0A0A0MSY4","A0A0A0MSY4_HUMAN",null,null,"DOCK9"]
["16.8387","16.6712","18.6308","17.7221",{"$nulls":3},"G-protein coupled receptor signaling pathway;positive regulation of cAMP biosynthetic process;positive regulation of protein kinase A signaling;protein targeting;regulation of protein kinase C signaling","adenylate cyclase binding;protein kinase A binding","cell cortex;cytoplasm;cytoskeleton;cytosol;focal adhesion;plasma membrane",{"$nulls":3},20,20,20,"20.5","20.5","20.5","191.48",0,"120.9",372670000,61,"1.03911","0.299638","-1.42145","-3.07671","sp|Q02952|AKA12_HUMAN","sp|Q02952|AKA12_HUMAN",1435,"Q02952","AKA12_HUMAN","A-kinase anchor protein 12","KAP-12","AKAP12"]
["16.1841","14.9007","16.6286","17.3024",{"$nulls":5},"nucleoplasm",{"$nulls":3},2,2,2,"10.9","10.9","10.9","33.266","0.0010874","2.5187",23111000,4,"0.724521","0.353084","-1.42306","-1.96343","tr|F8VRD2|F8VRD2_HUMAN;sp|Q9H0H5|RGAP1_HUMAN;tr|F8W1E5|F8W1E5_HUMAN;tr|H0YIK5|H0YIK5_HUMAN","tr|F8VRD2|F8VRD2_HUMAN;sp|Q9H0H5|RGAP1_HUMAN;tr|F8W1E5|F8W1E5_HUMAN;tr|H0YIK5|H0YIK5_HUMAN",2559,"F8VRD2","F8VRD2_HUMAN",null,null,"RACGAP1"]
["15.4864","14.2567","17.5274","15.0638",{"$nulls":3},"regulation of TOR signaling",null,"cytoplasm;TORC1 complex;TORC2 complex","mTOR signaling pathway",null,null,3,3,3,"3.2","3.2","3.2","122.07",0,"3.8982",100050000,5,"0.38759","0.63348","-1.42404","-1.03437","sp|O43156|TTI1_HUMAN","sp|O43156|TTI1_HUMAN",230,"O43156","TTI1_HUMAN","TELO2-interacting protein 1 homolog",null,"TTI1"]
["16.6102","16.7116","18.4012","17.7698",{"$nulls":3},"cell division;chromosome separation;meiotic chromosome condensation;mitotic chromosome condensation","chromatin binding;histone binding","condensed chromosome;condensed chromosome, centromeric region;condensin complex;condensin core heterodimer;cytoplasm;cytosol;membrane;nuclear condensin complex;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"7.2","7.2","7.2","157.18",0,"25.008",193730000,31,"1.32916","0.334593","-1.42461","-4.45539","sp|Q15021|CND1_HUMAN;tr|E7EN77|E7EN77_HUMAN;tr|F5H431|F5H431_HUMAN;tr|F5GZK7|F5GZK7_HUMAN","sp|Q15021|CND1_HUMAN;tr|E7EN77|E7EN77_HUMAN",1664,"Q15021","CND1_HUMAN","Condensin complex subunit 1",null,"NCAPD2"]
["16.4587","16.13","18.3433","17.0983",{"$nulls":3},"activation of MAPK activity;activation of protein kinase activity;cardiac muscle contraction;inflammatory response;positive regulation of protein kinase activity;positive regulation of transcription, DNA-templated;proteolysis in other organism;regulation of apoptotic process;regulation of cytokine biosynthetic process;regulation of mitotic cell cycle;signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;MAP kinase kinase activity;protein kinase binding;protein serine/threonine kinase activity;protein tyrosine kinase activity","cytoplasm;cytosol;membrane;nucleoplasm","Amyotrophic lateral sclerosis (ALS);Cellular senescence;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;GnRH signaling pathway;Hepatitis B;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;MAPK signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Rap1 signaling pathway;Thermogenesis;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Yersinia infection",null,null,2,2,2,"6.1","6.1","6.1","39.318",0,"5.3873",43862000,9,"0.803838","0.328292","-1.42637","-2.21545","sp|P46734|MP2K3_HUMAN;tr|J3KRV4|J3KRV4_HUMAN;sp|P52564|MP2K6_HUMAN;sp|P45985|MP2K4_HUMAN","sp|P46734|MP2K3_HUMAN;tr|J3KRV4|J3KRV4_HUMAN;sp|P52564|MP2K6_HUMAN;sp|P45985|MP2K4_HUMAN",1030,"P46734","MP2K3_HUMAN","Dual specificity mitogen-activated protein kinase kinase 3","AP kinase kinase 3;APKK 3","MAP2K3"]
["15.2717","15.0365","16.5129","16.6486",{"$nulls":3},"phosphatidylinositol dephosphorylation","hydrolase activity","cytosol",{"$nulls":3},2,1,1,"2.7","1.5","1.5","90.559",0,"4.9854",22443000,3,"2.04889","0.413045","-1.42666","-10.508","tr|H0Y5Q9|H0Y5Q9_HUMAN;sp|Q92835|SHIP1_HUMAN","tr|H0Y5Q9|H0Y5Q9_HUMAN;sp|Q92835|SHIP1_HUMAN",2195,"H0Y5Q9","H0Y5Q9_HUMAN",null,null,"INPP5D"]
["19.536","19.2894","20.9266","20.756",{"$nulls":3},"chromatin silencing at telomere;DNA packaging;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;histone H4 acetylation;internal protein amino acid acetylation;response to nutrient","H4 histone acetyltransferase activity;histone acetyltransferase activity;histone binding","cytoplasm;intracellular membrane-bounded organelle;nuclear chromatin;nuclear chromosome, telomeric region;nuclear matrix;nucleoplasm;nucleus;protein complex","Alcoholism",null,null,5,5,5,"16.9","16.9","16.9","49.512",0,"20.722",226550000,28,"1.96497","0.399934","-1.42857","-9.52643","sp|O14929|HAT1_HUMAN;tr|F8WEW1|F8WEW1_HUMAN;tr|F8W9G7|F8W9G7_HUMAN","sp|O14929|HAT1_HUMAN",182,"O14929","HAT1_HUMAN","Histone acetyltransferase type B catalytic subunit",null,"HAT1"]
["18.7802","19.3026","20.7734","20.2034",{"$nulls":4},"metal ion binding","cytosol",{"$nulls":3},3,3,3,17,17,17,"32.962",0,"42.534",127070000,10,"1.19008","0.322787","-1.44695","-3.74271","sp|Q96H79|ZCCHL_HUMAN","sp|Q96H79|ZCCHL_HUMAN",2285,"Q96H79","ZCCHL_HUMAN","Zinc finger CCCH-type antiviral protein 1-like",null,"ZC3HAV1L"]
["16.0982","15.9051","17.6908","17.2206",{"$nulls":3},"CMP salvage;CTP salvage;pyrimidine nucleobase metabolic process;pyrimidine nucleoside salvage;UMP salvage","ATP binding;nucleoside kinase activity;uridine kinase activity","cytosol","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,1,1,1,5,5,5,"29.299","0.00075672","2.8713",20473000,4,"1.5343","0.316857","-1.45405","-5.7209","sp|Q9BZX2|UCK2_HUMAN","sp|Q9BZX2|UCK2_HUMAN",2525,"Q9BZX2","UCK2_HUMAN","Uridine-cytidine kinase 2","CK 2","UCK2"]
["15.4193","14.8749","16.8585","16.3454",{"$nulls":3},"axonogenesis;brain morphogenesis;cell-cell adhesion;dendrite morphogenesis;positive regulation of muscle cell differentiation;prepulse inhibition;radial glia guided migration of Purkinje cell;regulation of synapse structural plasticity","actin filament binding;cadherin binding;identical protein binding;structural constituent of cytoskeleton","actin cytoskeleton;adherens junction;axon;basolateral plasma membrane;cell-cell adherens junction;cytoplasm;cytosol;lamellipodium;nucleus;postsynaptic density","Adherens junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Endometrial cancer;Gastric cancer;Hippo signaling pathway;Leukocyte transendothelial migration;Pathways in cancer",null,null,7,1,1,"8.5","1.9","1.9","105.31",0,"9.6155",33990000,9,"1.2204","0.315933","-1.45487","-3.8893","sp|P26232|CTNA2_HUMAN;tr|C9J144|C9J144_HUMAN;tr|C9IZ88|C9IZ88_HUMAN","sp|P26232|CTNA2_HUMAN",807,"P26232","CTNA2_HUMAN","Catenin alpha-2",null,"CTNNA2"]
["17.0458","16.659","19.5204","17.1046",{"$nulls":3},"aromatic amino acid family metabolic process","dioxygenase activity;metal ion binding;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen",{"$nulls":4},2,2,2,"6.5","6.5","6.5","39.385","0.00040064","3.385",24881000,3,"0.449756","0.552835","-1.46009","-1.19361","sp|Q96IR7|HPDL_HUMAN","sp|Q96IR7|HPDL_HUMAN",2298,"Q96IR7","HPDL_HUMAN","4-hydroxyphenylpyruvate dioxygenase-like protein",null,"HPDL"]
["20.6264","18.263","21.1426","20.6675",{"$nulls":3},"dATP catabolic process;defense response to virus;deoxyribonucleotide catabolic process;dGTP catabolic process;immune response;protein homotetramerization;regulation of innate immune response;type I interferon signaling pathway","dGTP binding;dGTPase activity;identical protein binding;nucleic acid binding;ribonuclease activity;RNA binding;triphosphoric monoester hydrolase activity;zinc ion binding","intracellular;nucleoplasm;nucleus;plasma membrane","Human immunodeficiency virus 1 infection",null,null,6,6,6,"12.6","12.6","12.6","72.2",0,"32.5",505460000,35,"0.456679","0.545351","-1.46034","-1.21157","sp|Q9Y3Z3|SAMH1_HUMAN","sp|Q9Y3Z3|SAMH1_HUMAN",2990,"Q9Y3Z3","SAMH1_HUMAN","Deoxynucleoside triphosphate triphosphohydrolase SAMHD1","NTPase","SAMHD1"]
["17.0147","17.1951","18.6179","18.515",{"$nulls":3},"endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosome assembly;rRNA processing","GTP binding;GTPase activity;RNA binding;U3 snoRNA binding","cytosol;nucleolus;nucleoplasm;preribosome, small subunit precursor",{"$nulls":3},4,4,4,"9.8","9.8","9.8","91.809",0,"8.5598",117370000,15,"2.29996","0.430989","-1.4616","-14.0715","sp|Q2NL82|TSR1_HUMAN;tr|I3L1Q5|I3L1Q5_HUMAN","sp|Q2NL82|TSR1_HUMAN;tr|I3L1Q5|I3L1Q5_HUMAN",1772,"Q2NL82","TSR1_HUMAN","Pre-rRNA-processing protein TSR1 homolog",null,"TSR1"]
["19.3703","19.2997","20.8823","20.7152",{"$nulls":3},"establishment of endothelial intestinal barrier;hippo signaling;intestinal absorption;negative regulation of osteoclast development;regulation of membrane permeability;TNFSF11-mediated signaling pathway","cadherin binding;guanylate kinase activity;protein binding, bridging;protein C-terminus binding;protein domain specific binding","adherens junction;bicellular tight junction;cell junction;cytosol;nucleoplasm;plasma membrane","Tight junction;Vibrio cholerae infection",null,null,11,11,11,"14.5","14.5","14.5","133.96",0,"155.99",747820000,24,"2.41818","0.480533","-1.46381","-16.1377","sp|Q9UDY2|ZO2_HUMAN;tr|U3KQJ2|U3KQJ2_HUMAN;tr|B1AN86|B1AN86_HUMAN","sp|Q9UDY2|ZO2_HUMAN",2817,"Q9UDY2","ZO2_HUMAN","Tight junction protein ZO-2",null,"TJP2"]
["18.6665","18.5523","20.3184","19.833",{"$nulls":9},1,1,1,"24.7","24.7","24.7","8.2873",0,"3.6942",32458000,8,"1.55728","0.333801","-1.46631","-5.88117","tr|D6R918|D6R918_HUMAN;tr|D6RBC5|D6RBC5_HUMAN;tr|D6RDI5|D6RDI5_HUMAN;tr|D6RA54|D6RA54_HUMAN;tr|D6RC55|D6RC55_HUMAN;tr|D6RG39|D6RG39_HUMAN;tr|D6RIT9|D6RIT9_HUMAN;sp|Q9NX40|OCAD1_HUMAN","tr|D6R918|D6R918_HUMAN;tr|D6RBC5|D6RBC5_HUMAN;tr|D6RDI5|D6RDI5_HUMAN;tr|D6RA54|D6RA54_HUMAN;tr|D6RC55|D6RC55_HUMAN;tr|D6RG39|D6RG39_HUMAN;tr|D6RIT9|D6RIT9_HUMAN;sp|Q9NX40|OCAD1_HUMAN",2734,"D6R918","D6R918_HUMAN",null,null,"OCIAD1"]
["17.7302","17.7542","19.116","19.3022",{"$nulls":3},"DNA biosynthetic process;DNA ligation involved in DNA repair;DNA recombination;DNA replication","ATP binding;DNA binding;DNA ligase (ATP) activity",{"$nulls":4},10,10,10,"17.5","17.5","17.5","88.386",0,"51.023",240580000,26,"2.39052","0.474633","-1.46687","-15.629","tr|M0R0Q7|M0R0Q7_HUMAN;sp|P18858|DNLI1_HUMAN;tr|B4E135|B4E135_HUMAN;tr|F5GZ28|F5GZ28_HUMAN;tr|M0QY71|M0QY71_HUMAN;tr|M0R1G7|M0R1G7_HUMAN","tr|M0R0Q7|M0R0Q7_HUMAN;sp|P18858|DNLI1_HUMAN;tr|B4E135|B4E135_HUMAN;tr|F5GZ28|F5GZ28_HUMAN",725,"M0R0Q7","M0R0Q7_HUMAN","DNA ligase {ECO:0000256|RuleBase:RU000617}",null,"LIG1"]
["15.6171","15.9356","17.392","17.1585",{"$nulls":3},"contact inhibition;negative regulation of cell growth;negative regulation of cell migration;negative regulation of cell proliferation;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of MAP kinase activity;negative regulation of platelet-derived growth factor receptor signaling pathway;negative regulation of protein kinase B signaling;negative regulation of T cell receptor signaling pathway;negative regulation of vascular permeability;neutrophil degranulation;peptidyl-tyrosine dephosphorylation;platelet-derived growth factor receptor signaling pathway;positive chemotaxis;positive regulation of cell adhesion;positive regulation of focal adhesion assembly;positive regulation of protein kinase B signaling;regulation of cell adhesion;T cell receptor signaling pathway","beta-catenin binding;delta-catenin binding;gamma-catenin binding;mitogen-activated protein kinase binding;phosphatase activity;platelet-derived growth factor receptor binding;protein kinase binding;protein tyrosine phosphatase activity","cell surface;cell-cell junction;extracellular exosome;immunological synapse;integral component of plasma membrane;plasma membrane;ruffle membrane;specific granule membrane","Adherens junction",null,null,3,3,3,"3.9","3.9","3.9","145.94",0,"4.557",49055000,10,"1.7716","0.359584","-1.49891","-7.58989","sp|Q12913|PTPRJ_HUMAN;tr|A0A087WTK0|A0A087WTK0_HUMAN;tr|A0A087WVC6|A0A087WVC6_HUMAN","sp|Q12913|PTPRJ_HUMAN;tr|A0A087WTK0|A0A087WTK0_HUMAN;tr|A0A087WVC6|A0A087WVC6_HUMAN",1507,"Q12913","PTPRJ_HUMAN","Receptor-type tyrosine-protein phosphatase eta",{"$f":"-PTP-eta,rotein-tyrosine phosphatase eta","v":{"$error":"#NAME?"}},"PTPRJ"]
["14.4339","13.4027","15.9585","14.8836",{"$nulls":3},"chromatin remodeling","DNA binding","nucleoplasm;SWI/SNF superfamily-type complex",{"$nulls":3},2,2,2,3,3,3,"129.37",0,"3.7962",19167000,5,"0.742048","0.342068","-1.5027","-2.01772","tr|H0Y488|H0Y488_HUMAN;sp|O14497|ARI1A_HUMAN","tr|H0Y488|H0Y488_HUMAN;sp|O14497|ARI1A_HUMAN",157,"H0Y488","H0Y488_HUMAN",null,null,"ARID1A"]
["23.2437","23.6824","26.4825","23.4585",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"10.2","10.2","10.2","13.328","0.0004029","3.4141",1914800000,9,"0.368751","0.659717","-1.50751","-0.986688","tr|X6RI56|X6RI56_HUMAN;sp|O94886|CSCL1_HUMAN","tr|X6RI56|X6RI56_HUMAN;sp|O94886|CSCL1_HUMAN",396,"X6RI56","X6RI56_HUMAN",null,null,"TMEM63A"]
["15.581","15.6285","15.7858","18.4432",{"$nulls":3},"endosomal transport;endosome organization;protein transport",null,"early endosome;endosome;WASH complex","Endocytosis",null,null,4,4,4,"4.5","4.5","4.5","136.4",0,"6.2659",88129000,7,"0.427442","0.587344","-1.50973","-1.13606","sp|Q2M389|WASH7_HUMAN;tr|A0A087X256|A0A087X256_HUMAN;tr|F8VYH7|F8VYH7_HUMAN","sp|Q2M389|WASH7_HUMAN;tr|A0A087X256|A0A087X256_HUMAN;tr|F8VYH7|F8VYH7_HUMAN",1770,"Q2M389","WASC4_HUMAN","WASH complex subunit 4 {ECO:0000312|HGNC:HGNC:29174}",null,"WASHC4"]
["15.2448","15.0768","16.793","16.5502",{"$nulls":3},"negative regulation of cell migration;positive regulation of anion channel activity;positive regulation of protein targeting to membrane","ion channel binding","plasma membrane",{"$nulls":3},1,1,1,"1.3","1.3","1.3","102.12",0,"13.38",34810000,6,"2.02628","0.40977","-1.51077","-10.2343","sp|Q9Y4C2|TCAF1_HUMAN","sp|Q9Y4C2|TCAF1_HUMAN",2995,"Q9Y4C2","TCAF1_HUMAN","TRPM8 channel-associated factor 1 {ECO:0000303|PubMed:25559186}",null,"TCAF1"]
["23.7818","22.005","24.3302","24.4923",{"$nulls":3},"translation","structural constituent of ribosome","cytosolic large ribosomal subunit",{"$nulls":3},3,3,3,14,14,14,"23.134",0,"97.829",916530000,22,"0.636474","0.407378","-1.51789","-1.70151","tr|J3QR09|J3QR09_HUMAN;tr|J3KTE4|J3KTE4_HUMAN;sp|P84098|RL19_HUMAN;tr|J3QL15|J3QL15_HUMAN","tr|J3QR09|J3QR09_HUMAN;tr|J3KTE4|J3KTE4_HUMAN;sp|P84098|RL19_HUMAN",1392,"J3QR09","J3QR09_HUMAN","Ribosomal protein L19 {ECO:0000256|RuleBase:RU000574}",null,"RPL19"]
["16.86","17.2111","18.8985","18.211",{"$nulls":4},"ATP binding;ATPase activity, coupled to transmembrane movement of substances;cation:chloride symporter activity","integral component of membrane",{"$nulls":3},5,5,5,7,7,7,"124.59",0,"48.135",125630000,16,"1.2298","0.316927","-1.5192","-3.93569","tr|G3XAL9|G3XAL9_HUMAN;sp|P55011|S12A2_HUMAN","tr|G3XAL9|G3XAL9_HUMAN;sp|P55011|S12A2_HUMAN",1202,"G3XAL9","G3XAL9_HUMAN"]
["15.3016","15.3709","17.5975","16.1299",{"$nulls":3},"apoptotic process;blastocyst formation;blood coagulation;camera-type eye morphogenesis;macroautophagy;mitochondrial fusion;mitochondrial membrane organization;mitochondrion localization;negative regulation of Ras protein signal transduction;negative regulation of smooth muscle cell proliferation;parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization;protein localization to phagophore assembly site;protein targeting to mitochondrion;response to unfolded protein","GTP binding;GTPase activity;ubiquitin protein ligase binding","cytosol;integral component of membrane;intrinsic component of mitochondrial outer membrane;microtubule cytoskeleton;mitochondrial outer membrane;mitochondrion","Mitophagy - animal;NOD-like receptor signaling pathway",null,null,2,2,2,"4.6","4.6","4.6","86.401",0,"6.9313",33290000,4,"0.761632","0.337061","-1.52744","-2.07929","sp|O95140|MFN2_HUMAN;tr|Q5JXC5|Q5JXC5_HUMAN","sp|O95140|MFN2_HUMAN;tr|Q5JXC5|Q5JXC5_HUMAN",411,"O95140","MFN2_HUMAN","Mitofusin-2",null,"MFN2"]
["18.3608","18.3705","19.494","20.3145",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;inflammatory response;mRNA processing;mRNA splicing, via spliceosome;response to lipopolysaccharide;RNA metabolic process","AU-rich element binding;protein kinase binding;RNA binding","intracellular ribonucleoprotein complex;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"9.5","9.5","9.5","30.84",0,"9.14",66293000,9,"1.19169","0.324161","-1.53863","-3.75034","sp|Q13151|ROA0_HUMAN","sp|Q13151|ROA0_HUMAN",1528,"Q13151","ROA0_HUMAN","Heterogeneous nuclear ribonucleoprotein A0","nRNP A0","HNRNPA0"]
["17.0424","17.9153","19.4661","18.5702",{"$nulls":9},3,3,3,"11.4","11.4","11.4","51.556",0,"16.51",82748000,13,"0.876375","0.304149","-1.53934","-2.46137","tr|A0A0D9SF63|A0A0D9SF63_HUMAN;sp|Q9BZK7|TBL1R_HUMAN;tr|C9JLJ1|C9JLJ1_HUMAN;tr|C9JCK0|C9JCK0_HUMAN;tr|C9JBN1|C9JBN1_HUMAN;tr|A0A0D9SF25|A0A0D9SF25_HUMAN;tr|F8W9D8|F8W9D8_HUMAN;tr|C9IYU9|C9IYU9_HUMAN;sp|Q9BQ87|TBL1Y_HUMAN;sp|O60907|TBL1X_HUMAN","tr|A0A0D9SF63|A0A0D9SF63_HUMAN;sp|Q9BZK7|TBL1R_HUMAN",2522,"A0A0D9SF63","A0A0D9SF63_HUMAN",null,null,"TBL1XR1"]
["19.5531","17.7427","20.2499","20.1274",{"$nulls":3},"negative regulation of protein localization to nucleus;negative regulation of transcription from RNA polymerase II promoter;transcription from RNA polymerase II promoter","cadherin binding involved in cell-cell adhesion;DNA binding transcription factor activity;identical protein binding;p53 binding;zinc ion binding","cell-cell adherens junction;cytoplasm",{"$nulls":3},7,7,7,"14.3","14.3","14.3","65.834",0,"35.78",298090000,24,"0.63536","0.408207","-1.5408","-1.6983","sp|Q14134|TRI29_HUMAN;tr|E9PRL4|E9PRL4_HUMAN;tr|E9PI31|E9PI31_HUMAN;tr|E9PLI4|E9PLI4_HUMAN;tr|E9PJ94|E9PJ94_HUMAN;tr|E9PM74|E9PM74_HUMAN;tr|E9PPX1|E9PPX1_HUMAN;tr|H0YD78|H0YD78_HUMAN;tr|E9PIQ2|E9PIQ2_HUMAN;tr|H0YF27|H0YF27_HUMAN;tr|E9PJD4|E9PJD4_HUMAN","sp|Q14134|TRI29_HUMAN;tr|E9PRL4|E9PRL4_HUMAN",1600,"Q14134","TRI29_HUMAN","Tripartite motif-containing protein 29",null,"TRIM29"]
["18.489","18.2903","20.2249","19.6482",{"$nulls":3},"RNA processing","RNA binding","mitochondrion",{"$nulls":3},7,7,7,"27.1","27.1","27.1","47.27",0,"45.023",182140000,17,"1.43485","0.332693","-1.54693","-5.07219","tr|H0Y8R1|H0Y8R1_HUMAN;tr|F5H5I6|F5H5I6_HUMAN;tr|H0YAK1|H0YAK1_HUMAN;sp|Q12849|GRSF1_HUMAN;tr|H0YAM1|H0YAM1_HUMAN","tr|H0Y8R1|H0Y8R1_HUMAN;tr|F5H5I6|F5H5I6_HUMAN;tr|H0YAK1|H0YAK1_HUMAN;sp|Q12849|GRSF1_HUMAN",1500,"H0Y8R1","H0Y8R1_HUMAN",null,null,"GRSF1"]
["16.4369","16.5364","17.8717","18.2024",{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},1,1,1,7,7,7,"25.477","0.0075833","1.763",23207000,5,"1.91425","0.39584","-1.55038","-8.97695","tr|M0QX71|M0QX71_HUMAN;sp|Q9BQ67|GRWD1_HUMAN","tr|M0QX71|M0QX71_HUMAN;sp|Q9BQ67|GRWD1_HUMAN",2414,"M0QX71","M0QX71_HUMAN",null,null,"GRWD1"]
["15.7867","17.9559","18.6644","18.1807",{"$nulls":5},"Golgi apparatus",{"$nulls":3},2,2,2,"5.8","5.8","5.8","46.701",0,"4.9473",25829000,6,"0.526525","0.499288","-1.55131","-1.396","sp|Q96M27|PRRC1_HUMAN","sp|Q96M27|PRRC1_HUMAN",2327,"Q96M27","PRRC1_HUMAN","Protein PRRC1",null,"PRRC1"]
["21.9134","22.9295","24.1866","23.7713",{"$nulls":3},"regulation of microtubule polymerization or depolymerization",{"$nulls":5},4,4,3,"49.4","49.4","38.8","9.7931",0,"7.5657",508490000,21,"0.978933","0.295834","-1.55753","-2.83799","tr|A2A2D0|A2A2D0_HUMAN;sp|P16949|STMN1_HUMAN","tr|A2A2D0|A2A2D0_HUMAN;sp|P16949|STMN1_HUMAN",701,"A2A2D0","A2A2D0_HUMAN","Stathmin {ECO:0000256|RuleBase:RU004388}",null,"STMN1"]
["19.7413","21.4312","22.669","21.66",{"$nulls":3},"dosage compensation by inactivation of X chromosome;regulation of translational initiation;response to stress","RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;nucleus","RNA transport",null,null,3,3,3,"41.6","41.6","41.6","12.732",0,"54.884",173980000,12,"0.602107","0.43335","-1.57823","-1.6037","sp|P41567|EIF1_HUMAN;tr|K7EM18|K7EM18_HUMAN;sp|O60739|EIF1B_HUMAN","sp|P41567|EIF1_HUMAN;tr|K7EM18|K7EM18_HUMAN;sp|O60739|EIF1B_HUMAN",987,"P41567","EIF1_HUMAN","Eukaryotic translation initiation factor 1","IF1","EIF1"]
["21.5079","20.4946","22.9141","22.2622",{"$nulls":3},"negative regulation of canonical Wnt signaling pathway;Ras protein signal transduction","ATP binding;ATP-dependent DNA helicase activity;ATP-dependent RNA helicase activity;DNA binding;endonuclease activity;mRNA binding;RNA binding","cytoplasmic stress granule;cytosol;focal adhesion;intracellular ribonucleoprotein complex;nucleus;plasma membrane",{"$nulls":3},9,9,8,"24.2","24.2","22.5","52.164",0,"174.07",885800000,41,"0.924586","0.294563","-1.58684","-2.63393","sp|Q13283|G3BP1_HUMAN;tr|E5RI46|E5RI46_HUMAN;tr|E5RIF8|E5RIF8_HUMAN;tr|E5RH42|E5RH42_HUMAN;tr|E5RIZ6|E5RIZ6_HUMAN;tr|E5RJU8|E5RJU8_HUMAN;tr|E5RH00|E5RH00_HUMAN","sp|Q13283|G3BP1_HUMAN",1540,"Q13283","G3BP1_HUMAN","Ras GTPase-activating protein-binding protein 1","3BP-1","G3BP1"]
["17.5159","18.5658","19.7123","19.5448",{"$nulls":3},"covalent chromatin modification;positive regulation of rRNA processing;regulation of transcription, DNA-templated;rRNA (guanine-N7)-methylation;rRNA methylation;transcription, DNA-templated","methyltransferase activity;protein heterodimerization activity;RNA binding;rRNA (guanine) methyltransferase activity","nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},3,3,3,"17.4","17.4","17.4","31.88",0,"21.145",56517000,8,"1.01686","0.294303","-1.58771","-2.98681","sp|O43709|WBS22_HUMAN;tr|H7C170|H7C170_HUMAN;tr|H7C0G4|H7C0G4_HUMAN","sp|O43709|WBS22_HUMAN;tr|H7C170|H7C170_HUMAN",261,"O43709","BUD23_HUMAN","Probable 18S rRNA (guanine-N(7))-methyltransferase {ECO:0000305}",null,"BUD23"]
["18.2713","18.0743","21.313","18.2272",{"$nulls":3},"layer formation in cerebral cortex;phosphatidylinositol acyl-chain remodeling;phospholipid biosynthetic process;ventricular system development","1-acylglycerol-3-phosphate O-acyltransferase activity;2-acylglycerol-3-phosphate O-acyltransferase activity;lysophospholipid acyltransferase activity","endoplasmic reticulum membrane;integral component of membrane;membrane","Glycerophospholipid metabolism",null,null,3,3,3,"8.7","8.7","8.7","52.764",0,"3.6484",94575000,3,"0.387111","0.632753","-1.59729","-1.03315","sp|Q96N66|MBOA7_HUMAN","sp|Q96N66|MBOA7_HUMAN",2329,"Q96N66","MBOA7_HUMAN","Lysophospholipid acyltransferase 7 {ECO:0000305}","PLAT 7 {ECO:0000305}","MBOAT7"]
["16.7024","16.2002","17.712","18.3861",{"$nulls":3},"Golgi organization;negative regulation of neuron projection development;negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of protein refolding;negative regulation of protein ubiquitination;negative regulation of ubiquitin-protein transferase activity;neuron death;protein folding;regulation of cellular response to heat;regulation of inclusion body assembly;regulation of ubiquitin-protein transferase activity","adenyl-nucleotide exchange factor activity;chaperone binding;protein kinase binding;ubiquitin protein ligase binding","cytosol;inclusion body;membrane;mitochondrion;nucleus;perinuclear region of cytoplasm",{"$nulls":3},3,3,3,"9.4","9.4","9.4","51.199",0,"13.031",47840000,16,"1.20233","0.328767","-1.59771","-3.80138","sp|Q9UL15|BAG5_HUMAN","sp|Q9UL15|BAG5_HUMAN",2882,"Q9UL15","BAG5_HUMAN","BAG family molecular chaperone regulator 5","AG-5","BAG5"]
["13.5587","13.0988","15.3642","14.4927",{"$nulls":3},"brain development;mitochondrial tRNA modification;negative regulation of cyclin-dependent protein serine/threonine kinase activity;positive regulation of mitochondrial translation;positive regulation of translational fidelity;regulation of neuron differentiation","4 iron, 4 sulfur cluster binding;metal ion binding;N6-isopentenyladenosine methylthiotransferase activity;protein complex binding;protein kinase binding","mitochondrion",{"$nulls":3},1,1,1,"2.8","2.8","2.8","67.688","0.00039417","3.2586",7801600,2,"1.07996","0.307169","-1.59974","-3.24704","sp|Q96SZ6|CK5P1_HUMAN","sp|Q96SZ6|CK5P1_HUMAN",2358,"Q96SZ6","CK5P1_HUMAN","CDK5 regulatory subunit-associated protein 1",null,"CDK5RAP1"]
["24.1742","22.3934","25.1007","24.6957",{"$nulls":3},"cellular response to drug;cellular response to fatty acid;cellular response to glucose stimulus;CTP biosynthetic process;endocytosis;GTP biosynthetic process;hippocampus development;lactation;negative regulation of cell proliferation;negative regulation of gene expression;negative regulation of myeloid leukocyte differentiation;nucleobase-containing small molecule interconversion;positive regulation of DNA binding;positive regulation of epithelial cell proliferation;positive regulation of neuron projection development;regulation of apoptotic process;response to amine;response to cAMP;response to testosterone;UTP biosynthetic process","ATP binding;deoxyribonuclease activity;enzyme binding;gamma-tubulin binding;GTP binding;identical protein binding;intermediate filament binding;magnesium ion binding;nucleoside diphosphate kinase activity;ribosomal small subunit binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;single-stranded DNA binding","centrosome;cytoplasm;cytosol;extracellular exosome;intermediate filament;membrane;mitochondrial outer membrane;myelin sheath;nucleus;perinuclear region of cytoplasm;ruffle membrane","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,6,1,1,"39.5","9.2","9.2","17.149",0,"136.4",2042000000,15,"0.659349","0.390432","-1.61438","-1.76792","sp|P15531|NDKA_HUMAN","sp|P15531|NDKA_HUMAN",686,"P15531","NDKA_HUMAN","Nucleoside diphosphate kinase A","DK A;DP kinase A","NME1"]
["16.1647","15.9582","19.1855","16.2273",{"$nulls":3},"angiogenesis;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;apolipoprotein A-I-mediated signaling pathway;apoptotic cell clearance;calcium ion transmembrane transport;cell adhesion;cell adhesion mediated by integrin;cell-matrix adhesion;cell-substrate adhesion;endodermal cell differentiation;entry of symbiont into host cell by promotion of host phagocytosis;ERK1 and ERK2 cascade;extracellular matrix organization;extrinsic apoptotic signaling pathway in absence of ligand;heterotypic cell-cell adhesion;integrin-mediated signaling pathway;leukocyte migration;negative chemotaxis;negative regulation of entry of bacterium into host cell;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of lipid storage;negative regulation of lipid transport;negative regulation of lipoprotein metabolic process;negative regulation of low-density lipoprotein particle receptor biosynthetic process;negative regulation of macrophage derived foam cell differentiation;neutrophil degranulation;positive regulation of cell adhesion;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of cytosolic calcium ion concentration;positive regulation of MAPK cascade;positive regulation of osteoblast proliferation;regulation of apoptotic cell clearance;regulation of phagocytosis;substrate adhesion-dependent cell spreading;transforming growth factor-beta secretion;vascular endothelial growth factor receptor signaling pathway;vasculogenesis;viral entry into host cell","coreceptor activity;extracellular matrix binding;extracellular matrix protein binding;fibronectin binding;metal ion binding;opsonin binding;peptide binding;protease binding;protein kinase C binding;receptor binding;transforming growth factor beta binding;virus receptor activity;voltage-gated calcium channel activity","alphav-beta3 integrin-IGF-1-IGF1R complex;cell surface;cytosol;external side of plasma membrane;extracellular exosome;filopodium membrane;focal adhesion;integral component of plasma membrane;integrin alphav-beta3 complex;integrin alphav-beta5 complex;integrin alphav-beta6 complex;integrin alphav-beta8 complex;integrin complex;lamellipodium membrane;membrane;microvillus membrane;phagocytic vesicle;plasma membrane;ruffle membrane;specific granule membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Cell adhesion molecules (CAMs);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Fluid shear stress and atherosclerosis;Focal adhesion;Human cytomegalovirus infection;Human papillomavirus infection;Hypertrophic cardiomyopathy (HCM);Pathways in cancer;Phagosome;PI3K-Akt signaling pathway;Proteoglycans in cancer;Regulation of actin cytoskeleton;Small cell lung cancer;Thyroid hormone signaling pathway",null,null,5,5,5,"7.1","7.1","7.1","116.04",0,"17.538",114740000,17,"0.417043","0.599235","-1.64491","-1.1094","sp|P06756|ITAV_HUMAN;tr|H7BZG1|H7BZG1_HUMAN","sp|P06756|ITAV_HUMAN",537,"P06756","ITAV_HUMAN","Integrin alpha-V",null,"ITGAV"]
["16.5887","19.2134","19.3934","19.7096",{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},3,3,3,"4.5","4.5","4.5","97.394",0,"3.5832",126760000,6,"0.470899","0.532704","-1.65049","-1.24862","sp|Q9NTZ6|RBM12_HUMAN","sp|Q9NTZ6|RBM12_HUMAN",2702,"Q9NTZ6","RBM12_HUMAN","RNA-binding protein 12",null,"RBM12"]
["14.2331","13.4168","15.7926","15.1626",{"$nulls":3},"apoptotic process involved in morphogenesis;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand",null,"extracellular exosome;membrane raft","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Chagas disease (American trypanosomiasis);Dopaminergic synapse;Hepatitis C;Hippo signaling pathway;Human papillomavirus infection;Long-term depression;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway;TGF-beta signaling pathway;Tight junction",null,null,3,1,1,"8.2","3.2","3.2","66.213",0,"3.8771",12957000,4,"1.07014","0.304363","-1.65265","-3.20546","sp|P30154|2AAB_HUMAN","sp|P30154|2AAB_HUMAN",867,"P30154","2AAB_HUMAN","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform",null,"PPP2R1B"]
["19.6545","19.7679","21.3054","21.4345",{"$nulls":3},"DNA metabolic process;intracellular transport of virus;modulation by virus of host process;NLS-bearing protein import into nucleus;regulation of DNA recombination","histone deacetylase binding;nuclear localization sequence binding;protein transporter activity;RNA binding","cytoplasm;cytosol;host cell;membrane;nuclear pore;nucleoplasm","Influenza A",null,null,7,7,7,"20.2","20.2","20.2","57.861",0,"155.51",705800000,46,"2.5736","0.539077","-1.65873","-19.3166","sp|P52292|IMA1_HUMAN;tr|J3QLL0|J3QLL0_HUMAN;tr|J3KS65|J3KS65_HUMAN;tr|J3QL07|J3QL07_HUMAN","sp|P52292|IMA1_HUMAN;tr|J3QLL0|J3QLL0_HUMAN;tr|J3KS65|J3KS65_HUMAN",1153,"P52292","IMA1_HUMAN","Importin subunit alpha-1",null,"KPNA2"]
["14.3485",1,"17.7103",1,{"$nulls":9},1,1,1,"24.8","24.8","24.8","12.29",0,"3.944",4725600,1,"0.0508385","0.949914","-1.68091","-0.157188","tr|D6RGY8|D6RGY8_HUMAN;tr|D6RFI3|D6RFI3_HUMAN;sp|Q9GZM5|YIPF3_HUMAN;tr|E7EQR8|E7EQR8_HUMAN","tr|D6RGY8|D6RGY8_HUMAN;tr|D6RFI3|D6RFI3_HUMAN;sp|Q9GZM5|YIPF3_HUMAN;tr|E7EQR8|E7EQR8_HUMAN",2534,"D6RGY8","D6RGY8_HUMAN",null,null,"YIPF3"]
["14.1444","16.1149","17.2002","16.4686",{"$nulls":3},"dendrite morphogenesis;negative regulation of phosphatase activity;regulation of Rho protein signal transduction;synapse assembly","cytoskeletal protein binding;Rac guanyl-nucleotide exchange factor activity;Rho guanyl-nucleotide exchange factor activity","cell junction;cytoskeleton;cytosol;dendrite;dendritic spine;extrinsic component of cytoplasmic side of plasma membrane;filopodium",{"$nulls":3},2,2,2,"2.9","2.9","2.9","118.63",0,"6.5315",49340000,7,"0.608611","0.428247","-1.7047","-1.62204","sp|Q9Y4F1|FARP1_HUMAN;tr|C9JME2|C9JME2_HUMAN;tr|M0QYB0|M0QYB0_HUMAN","sp|Q9Y4F1|FARP1_HUMAN;tr|C9JME2|C9JME2_HUMAN;tr|M0QYB0|M0QYB0_HUMAN",2998,"Q9Y4F1","FARP1_HUMAN","FERM, ARHGEF and pleckstrin domain-containing protein 1",null,"FARP1"]
["20.371","22.193","23.5476","22.4931",{"$nulls":3},"assembly of large subunit precursor of preribosome;gene silencing by miRNA;maturation of 5.8S rRNA;maturation of LSU-rRNA;mature ribosome assembly;miRNA mediated inhibition of translation;positive regulation of translation;regulation of fatty acid biosynthetic process;regulation of glycolytic process;regulation of megakaryocyte differentiation;regulation of reactive oxygen species metabolic process;response to insulin;ribosomal subunit export from nucleus","ribosomal large subunit binding;ribosome binding;translation initiation factor activity","cytoplasm;cytosol;extracellular exosome;nucleolus;nucleoplasm;nucleus;preribosome, large subunit precursor","Ribosome biogenesis in eukaryotes",null,null,6,6,6,"40.4","40.4","40.4","26.599",0,"217.38",536740000,39,"0.619005","0.423159","-1.73831","-1.65151","sp|P56537|IF6_HUMAN;tr|B7ZBH1|B7ZBH1_HUMAN","sp|P56537|IF6_HUMAN",1224,"P56537","IF6_HUMAN","Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132}","IF-6 {ECO:0000255|HAMAP-Rule:MF_03132}"]
["12.1011",1,"15.5942",1,{"$nulls":3},"centrosome cycle;chromatin assembly or disassembly;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;spindle organization;transcription, DNA-templated","ATP binding;ATP-dependent DNA helicase activity;DNA binding;helicase activity;histone deacetylase activity;RNA binding;zinc ion binding","centrosome;cytoplasm;microtubule organizing center;nucleolus;nucleoplasm;nucleus;NuRD complex",{"$nulls":3},4,2,2,"3.4","1.6","1.6","226.59","0.0094555","1.6918",12947000,1,"0.0622303","0.940843","-1.74654","-0.190499","sp|Q12873|CHD3_HUMAN;tr|I3L229|I3L229_HUMAN;tr|H7C3H7|H7C3H7_HUMAN;tr|H7C0J3|H7C0J3_HUMAN","sp|Q12873|CHD3_HUMAN",1501,"Q12873","CHD3_HUMAN","Chromodomain-helicase-DNA-binding protein 3","HD-3","CHD3"]
["19.8144","15.893","19.9268","19.2763",{"$nulls":9},4,4,4,"24.3","24.3","24.3","25.73",0,"6.4263",82135000,5,"0.326117","0.70584","-1.74779","-0.879406","tr|F8VRK6|F8VRK6_HUMAN;tr|H0YH87|H0YH87_HUMAN;tr|F8WB06|F8WB06_HUMAN;tr|F8VQP2|F8VQP2_HUMAN;tr|V9GY86|V9GY86_HUMAN;sp|Q99700|ATX2_HUMAN","tr|F8VRK6|F8VRK6_HUMAN;tr|H0YH87|H0YH87_HUMAN;tr|F8WB06|F8WB06_HUMAN;tr|F8VQP2|F8VQP2_HUMAN;tr|V9GY86|V9GY86_HUMAN;sp|Q99700|ATX2_HUMAN",2391,"F8VRK6","F8VRK6_HUMAN",null,null,"ATXN2"]
["15.6182","16.6105","18.0776","17.6622",{"$nulls":3},"regulation of transcription, DNA-templated;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","DNA binding;RNA binding","cytosol;nuclear speck;nucleoplasm;nucleus;transcription factor TFIID complex;transcription factor TFIIE complex","Basal transcription factors;Viral carcinogenesis",null,null,2,2,2,"7.9","7.9","7.9","33.043","0.0010815","2.4713",13538000,3,"1.08391","0.307811","-1.75554","-3.26389","sp|P29084|T2EB_HUMAN","sp|P29084|T2EB_HUMAN",842,"P29084","T2EB_HUMAN","Transcription initiation factor IIE subunit beta","FIIE-beta","GTF2E2"]
["16.4282","15.8552","18.035","17.7627",{"$nulls":3},"COPII vesicle coating;G1/S transition of mitotic cell cycle;innate immune response;protein dephosphorylation","metal ion binding;protein serine/threonine phosphatase activity","cytosol;Golgi membrane;mitochondrion",{"$nulls":3},2,2,2,"8.9","8.9","8.9","35.144",0,"5.0332",23846000,6,"1.50744","0.322163","-1.75714","-5.53867","sp|O00743|PPP6_HUMAN;tr|Q5T1S7|Q5T1S7_HUMAN","sp|O00743|PPP6_HUMAN;tr|Q5T1S7|Q5T1S7_HUMAN",155,"O00743","PPP6_HUMAN","Serine/threonine-protein phosphatase 6 catalytic subunit","P6C","PPP6C"]
["14.3493","17.5437","17.632","17.7801",{"$nulls":3},"cellular iron ion homeostasis;citrate metabolic process;intestinal absorption;post-embryonic development;regulation of translation;response to iron(II) ion;tricarboxylic acid cycle","3 iron, 4 sulfur cluster binding;4 iron, 4 sulfur cluster binding;aconitate hydratase activity;iron-responsive element binding;metal ion binding;RNA binding","cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;Golgi apparatus;mitochondrion","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Metabolic pathways",null,null,4,4,4,"8.7","8.7","8.7","98.398",0,"7.0811",96043000,9,"0.413568","0.600272","-1.75962","-1.10051","sp|P21399|ACOC_HUMAN","sp|P21399|ACOC_HUMAN",755,"P21399","ACOC_HUMAN","Cytoplasmic aconitate hydratase","conitase","ACO1"]
["17.2307","15.0378","18.0681","17.7838",{"$nulls":3},"ubiquitin-dependent protein catabolic process",{"$nulls":5},1,1,1,"22.5","22.5","22.5","9.9601",0,"5.8878",14971000,7,"0.608077","0.42838","-1.79173","-1.62053","tr|E5RHG8|E5RHG8_HUMAN;sp|Q15369|ELOC_HUMAN","tr|E5RHG8|E5RHG8_HUMAN;sp|Q15369|ELOC_HUMAN",1696,"E5RHG8","E5RHG8_HUMAN",null,null,"ELOC"]
["15.6438","15.3229","18.0172","16.5621",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;interstrand cross-link repair;protein autoubiquitination;protein K11-linked ubiquitination;protein K27-linked ubiquitination;protein K29-linked ubiquitination;protein K48-linked ubiquitination;protein K63-linked ubiquitination;protein K6-linked ubiquitination;protein monoubiquitination;protein ubiquitination","ATP binding;chromatin binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;nucleolus;nucleoplasm;nucleus","Fanconi anemia pathway",null,null,2,2,2,"15.2","15.2","15.2","22.521","0.00076075","2.905",20164000,4,"0.865793","0.302884","-1.80626","-2.4245","sp|Q9NPD8|UBE2T_HUMAN","sp|Q9NPD8|UBE2T_HUMAN",2660,"Q9NPD8","UBE2T_HUMAN","Ubiquitin-conjugating enzyme E2 T",null,"UBE2T"]
["16.8542","15.0183","17.9234","17.5658",{"$nulls":3},"transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding;signal transducer, downstream of receptor, with protein tyrosine kinase activity;transmembrane receptor protein tyrosine kinase activity","integral component of membrane;intracellular;plasma membrane",{"$nulls":3},4,4,4,"5.1","5.1","5.1","129.17",0,"14.439",123120000,12,"0.714832","0.359434","-1.80835","-1.93374","tr|E9PFD7|E9PFD7_HUMAN;sp|P00533|EGFR_HUMAN;tr|Q504U8|Q504U8_HUMAN;tr|A0A0B4J1Y5|A0A0B4J1Y5_HUMAN","tr|E9PFD7|E9PFD7_HUMAN;sp|P00533|EGFR_HUMAN;tr|Q504U8|Q504U8_HUMAN",472,"E9PFD7","E9PFD7_HUMAN","Receptor protein-tyrosine kinase {ECO:0000256|SAAS:SAAS00593197}",null,"EGFR"]
["15.1073","14.9048","17.0698","16.682",{"$nulls":3},"mRNA export from nucleus;regulation of gene expression;RNA secondary structure unwinding;RNA splicing","ATP binding;ATP-dependent RNA helicase activity;helicase activity;RNA binding","catalytic step 2 spliceosome;cytoplasm;extracellular exosome;membrane;nuclear envelope;nuclear membrane;nuclear pore;nucleolus",{"$nulls":3},6,1,1,15,"5.6","5.6","53.926","0.00040128","3.3969",17937000,4,"1.87238","0.387212","-1.86982","-8.54646","sp|Q9UMR2|DD19B_HUMAN;tr|H3BQK0|H3BQK0_HUMAN;tr|H3BMQ5|H3BMQ5_HUMAN;tr|H3BN59|H3BN59_HUMAN","sp|Q9UMR2|DD19B_HUMAN;tr|H3BQK0|H3BQK0_HUMAN;tr|H3BMQ5|H3BMQ5_HUMAN;tr|H3BN59|H3BN59_HUMAN",2901,"Q9UMR2","DD19B_HUMAN","ATP-dependent RNA helicase DDX19B",null,"DDX19B"]
["15.0601","15.0889","16.2625","17.6397",{"$nulls":3},"cell cycle;chromatin assembly;DNA repair;DNA replication;DNA replication-dependent nucleosome assembly;protein complex assembly;regulation of transcription, DNA-templated;transcription, DNA-templated","chromatin binding;histone binding;unfolded protein binding","CAF-1 complex;cytoplasm;nuclear chromatin;nucleoplasm;nucleus;protein complex",{"$nulls":3},2,2,2,"4.7","4.7","4.7","61.492",0,"15.8",26686000,9,"0.949125","0.294753","-1.87663","-2.72477","sp|Q13112|CAF1B_HUMAN","sp|Q13112|CAF1B_HUMAN",1521,"Q13112","CAF1B_HUMAN","Chromatin assembly factor 1 subunit B","AF-1 subunit B","CHAF1B"]
["13.6956","13.8056","15.7696","15.5279",{"$nulls":3},"adherens junction maintenance;brain morphogenesis;cerebral cortex development;homeostasis of number of cells;neuroepithelial cell differentiation;protein localization to cell junction;radial glial cell differentiation;regulation of oligodendrocyte progenitor proliferation;signal transduction","cell adhesion molecule binding","apical junction complex;apical part of cell;cell junction;cell-cell adherens junction;cytosol;nuclear speck;nucleoplasm;plasma membrane","Adherens junction;cAMP signaling pathway;Leukocyte transendothelial migration;Rap1 signaling pathway;Ras signaling pathway;Tight junction",null,null,2,2,2,"1.6","1.6","1.6","201.8","0.0010945","2.5624",19724000,3,"2.31361","0.451759","-1.89813","-14.2961","tr|A8MQ02|A8MQ02_HUMAN;sp|P55196|AFAD_HUMAN;tr|J3KN01|J3KN01_HUMAN;tr|H0Y8U8|H0Y8U8_HUMAN;tr|H0Y948|H0Y948_HUMAN;tr|H0Y8L4|H0Y8L4_HUMAN;tr|Q5TIG5|Q5TIG5_HUMAN","tr|A8MQ02|A8MQ02_HUMAN;sp|P55196|AFAD_HUMAN;tr|J3KN01|J3KN01_HUMAN;tr|H0Y8U8|H0Y8U8_HUMAN;tr|H0Y948|H0Y948_HUMAN;tr|H0Y8L4|H0Y8L4_HUMAN;tr|Q5TIG5|Q5TIG5_HUMAN",1207,"A8MQ02","A8MQ02_HUMAN",null,null,"AFDN"]
["16.4982","16.101","19.0606","17.3983",{"$nulls":9},2,2,2,"11.6","11.6","11.6","26.937",0,"4.0242",32731000,4,"0.816838","0.322496","-1.92988","-2.25838","tr|H7BYW5|H7BYW5_HUMAN;sp|P31321|KAP1_HUMAN;tr|C9JSK5|C9JSK5_HUMAN","tr|H7BYW5|H7BYW5_HUMAN;sp|P31321|KAP1_HUMAN;tr|C9JSK5|C9JSK5_HUMAN",885,"H7BYW5","H7BYW5_HUMAN",null,null,"PRKAR1B"]
["15.6117","15.1561","17.8186","16.8435",{"$nulls":3},"angiogenesis;cellular response to lipopolysaccharide;chronological cell aging;circadian rhythm;defense response to Gram-negative bacterium;extracellular matrix organization;fibrinolysis;negative regulation of blood coagulation;negative regulation of cell adhesion mediated by integrin;negative regulation of cell migration;negative regulation of endopeptidase activity;negative regulation of endothelial cell apoptotic process;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of fibrinolysis;negative regulation of plasminogen activation;negative regulation of smooth muscle cell migration;negative regulation of smooth muscle cell-matrix adhesion;negative regulation of vascular wound healing;negative regulation of wound healing;platelet degranulation;positive regulation of angiogenesis;positive regulation of blood coagulation;positive regulation of inflammatory response;positive regulation of interleukin-8 production;positive regulation of leukotriene production involved in inflammatory response;positive regulation of monocyte chemotaxis;positive regulation of receptor-mediated endocytosis;positive regulation of transcription from RNA polymerase II promoter;regulation of receptor activity;replicative senescence","protease binding;receptor binding;serine-type endopeptidase inhibitor activity","extracellular exosome;extracellular matrix;extracellular region;extracellular space;plasma membrane;platelet alpha granule lumen","AGE-RAGE signaling pathway in diabetic complications;Apelin signaling pathway;Cellular senescence;Chagas disease (American trypanosomiasis);Complement and coagulation cascades;HIF-1 signaling pathway;Hippo signaling pathway;p53 signaling pathway",null,null,1,1,1,"2.5","2.5","2.5","45.059","0.0011265","2.8051",16748000,2,"1.16363","0.311881","-1.94717","-3.61851","sp|P05121|PAI1_HUMAN","sp|P05121|PAI1_HUMAN",512,"P05121","PAI1_HUMAN","Plasminogen activator inhibitor 1","AI;AI-1","SERPINE1"]
["14.8891","14.8545","17.2937","16.3594",{"$nulls":3},"DNA replication","3'-5' exonuclease activity;4 iron, 4 sulfur cluster binding;DNA binding;DNA-directed DNA polymerase activity;metal ion binding;nucleoside binding;nucleotide binding","cytosol;nucleoplasm",{"$nulls":3},4,4,4,4,4,4,"165.77",0,"9.1434",76161000,10,"1.27805","0.32728","-1.95475","-4.18125","tr|A0A087WU64|A0A087WU64_HUMAN;sp|P09884|DPOLA_HUMAN;tr|A6NMQ1|A6NMQ1_HUMAN","tr|A0A087WU64|A0A087WU64_HUMAN;sp|P09884|DPOLA_HUMAN;tr|A6NMQ1|A6NMQ1_HUMAN",596,"A0A087WU64","A0A087WU64_HUMAN","DNA polymerase {ECO:0000256|RuleBase:RU000442}",null,"POLA1"]
["14.3407","15.2589","16.6314","16.9327",{"$nulls":3},"cilium assembly;microtubule anchoring at centrosome;protein localization to centrosome",null,"centrosome;cytosol;nuclear membrane",{"$nulls":3},8,8,8,"5.3","5.3","5.3","227.73",0,"21.057",121680000,19,"1.26287","0.324714","-1.98229","-4.10262","tr|E7ETA6|E7ETA6_HUMAN;tr|A6NNN6|A6NNN6_HUMAN;sp|Q15154|PCM1_HUMAN;tr|E5RGQ4|E5RGQ4_HUMAN;tr|E9PGW9|E9PGW9_HUMAN;tr|E7EV93|E7EV93_HUMAN;tr|H0YBA1|H0YBA1_HUMAN","tr|E7ETA6|E7ETA6_HUMAN;tr|A6NNN6|A6NNN6_HUMAN;sp|Q15154|PCM1_HUMAN;tr|E5RGQ4|E5RGQ4_HUMAN;tr|E9PGW9|E9PGW9_HUMAN;tr|E7EV93|E7EV93_HUMAN",3084,"E7ETA6","E7ETA6_HUMAN",null,null,"PCM1"]
["18.6388","15.4598","19.2297","18.8593",{"$nulls":3},"chromosome segregation;innate immune response;intracellular signal transduction;negative regulation of viral genome replication;positive regulation of viral genome replication;protein phosphorylation;regulation of mRNA processing;regulation of mRNA splicing, via spliceosome;RNA splicing;sperm chromatin condensation;spliceosomal complex assembly;viral process","ATP binding;magnesium ion binding;protein kinase activity;protein serine/threonine kinase activity;RNA binding","cytoplasm;cytosol;endoplasmic reticulum;nuclear matrix;nucleus;plasma membrane","Herpes simplex virus 1 infection",null,null,4,4,3,"8.5","8.5","7.2","74.324",0,"8.8392",108670000,11,"0.470205","0.534193","-1.99521","-1.24681","sp|Q96SB4|SRPK1_HUMAN;tr|H3BLV9|H3BLV9_HUMAN;tr|Q5R363|Q5R363_HUMAN;tr|D6RBF8|D6RBF8_HUMAN","sp|Q96SB4|SRPK1_HUMAN;tr|H3BLV9|H3BLV9_HUMAN;tr|Q5R363|Q5R363_HUMAN;tr|D6RBF8|D6RBF8_HUMAN",2355,"Q96SB4","SRPK1_HUMAN","SRSF protein kinase 1",null,"SRPK1"]
["19.9355","16.8805","20.899","19.9628",{"$nulls":3},"mitotic DNA replication termination;site-specific DNA replication termination at RTS1 barrier",null,"nucleus",{"$nulls":3},3,3,3,"13.7","13.7","13.7","33.886",0,"59.078",216370000,10,"0.477623","0.526607","-2.02293","-1.26623","sp|Q9BY42|RTF2_HUMAN;tr|A0A0A0MQR2|A0A0A0MQR2_HUMAN;tr|A2A2L5|A2A2L5_HUMAN;tr|A2A2L6|A2A2L6_HUMAN","sp|Q9BY42|RTF2_HUMAN;tr|A0A0A0MQR2|A0A0A0MQR2_HUMAN;tr|A2A2L5|A2A2L5_HUMAN",2504,"Q9BY42","RTF2_HUMAN","Protein RTF2 homolog",null,"RTFDC1"]
["16.1049","16.6257","18.9384","17.9124",{"$nulls":4},"DNA primase activity",{"$nulls":4},3,3,3,"11.3","11.3","11.3","38.947",0,"10.411",76747000,9,"1.15547","0.311245","-2.06009","-3.58087","tr|F8VNY2|F8VNY2_HUMAN;sp|P49642|PRI1_HUMAN;tr|F8VSB2|F8VSB2_HUMAN;tr|H0YIP2|H0YIP2_HUMAN","tr|F8VNY2|F8VNY2_HUMAN;sp|P49642|PRI1_HUMAN;tr|F8VSB2|F8VSB2_HUMAN",1084,"F8VNY2","F8VNY2_HUMAN","DNA primase {ECO:0000256|RuleBase:RU003514}",null,"PRIM1"]
["17.7062","18.2788","20.3237","19.8474",{"$nulls":9},2,2,2,"10.9","10.9","10.9","24.992",0,"9.9866",73837000,10,"1.51964","0.32531","-2.09302","-5.62079","sp|Q9H7E9|CH033_HUMAN","sp|Q9H7E9|CH033_HUMAN",2610,"Q9H7E9","CH033_HUMAN","UPF0488 protein C8orf33",null,"C8orf33"]
["17.5196","17.5201","20.0577","19.2868",{"$nulls":3},"cell proliferation in forebrain;deoxyribonucleotide biosynthetic process;DNA replication;male gonad development;mitotic cell cycle;nucleobase-containing small molecule interconversion;protein heterotetramerization;pyrimidine nucleobase metabolic process;response to ionizing radiation;retina development in camera-type eye","ATP binding;disordered domain specific binding;identical protein binding;ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor","cell projection;cytosol;extracellular exosome;neuronal cell body;nuclear envelope;ribonucleoside-diphosphate reductase complex","Drug metabolism - other enzymes;Glutathione metabolism;Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,6,6,6,"11.5","11.5","11.5","90.069",0,"242.82",366550000,33,"1.51417","0.322597","-2.1524","-5.58385","sp|P23921|RIR1_HUMAN;tr|E9PL69|E9PL69_HUMAN","sp|P23921|RIR1_HUMAN;tr|E9PL69|E9PL69_HUMAN",787,"P23921","RIR1_HUMAN","Ribonucleoside-diphosphate reductase large subunit",null,"RRM1"]
["16.553","15.0548","18.4014","17.541",{"$nulls":3},"negative regulation of protein ubiquitination;protein methylation;regulation of transcription, DNA-templated","histone-arginine N-methyltransferase activity;metal ion binding;methyltransferase activity;nucleic acid binding;protein-arginine N-methyltransferase activity;protein-arginine omega-N asymmetric methyltransferase activity","cytoplasm;cytosol;ribosome",{"$nulls":3},3,3,3,"7.9","7.9","7.9","59.875",0,"12.249",42604000,7,"0.889869","0.298616","-2.16727","-2.5089","sp|O60678|ANM3_HUMAN;tr|A0A0A0MSN7|A0A0A0MSN7_HUMAN","sp|O60678|ANM3_HUMAN;tr|A0A0A0MSN7|A0A0A0MSN7_HUMAN",298,"O60678","ANM3_HUMAN","Protein arginine N-methyltransferase 3",null,"PRMT3"]
["16.4826","16.105","18.5811","18.3796",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},3,3,3,"8.1","8.1","8.1","59.544",0,"22.643",75547000,15,"2.02498","0.406175","-2.18656","-10.2188","sp|Q86XZ4|SPAS2_HUMAN;tr|F8VS10|F8VS10_HUMAN","sp|Q86XZ4|SPAS2_HUMAN;tr|F8VS10|F8VS10_HUMAN",1998,"Q86XZ4","SPAS2_HUMAN","Spermatogenesis-associated serine-rich protein 2",null,"SPATS2"]
["18.1436","18.809","21.0587","20.2693",{"$nulls":3},"central nervous system development;signal transduction;synaptic vesicle uncoating","cadherin binding;GTPase binding;identical protein binding;lipid binding;phosphatase binding","cell junction;cell projection;cytoplasm;early endosome membrane;podosome;synapse","Endocytosis",null,null,5,5,5,"14.9","14.9","14.9","41.489",0,"8.0071",199240000,13,"1.28889","0.330701","-2.18774","-4.23816","sp|Q99961|SH3G1_HUMAN;tr|M0QYE0|M0QYE0_HUMAN;tr|M0R0I3|M0R0I3_HUMAN;sp|Q99962|SH3G2_HUMAN;tr|M0R2K6|M0R2K6_HUMAN","sp|Q99961|SH3G1_HUMAN;tr|M0QYE0|M0QYE0_HUMAN;tr|M0R0I3|M0R0I3_HUMAN",2402,"Q99961","SH3G1_HUMAN","Endophilin-A2",null,"SH3GL1"]
["14.9621","14.9917","16.1883","18.1683",{"$nulls":3},"ribosome biogenesis","GTP binding;RNA binding","chromosome;mitochondrion;nucleolus",{"$nulls":3},1,1,1,"3.9","3.9","3.9","42.932",0,"8.9006",49697000,6,"0.806249","0.327445","-2.20135","-2.22337","sp|A4D1E9|GTPBA_HUMAN","sp|A4D1E9|GTPBA_HUMAN",100,"A4D1E9","GTPBA_HUMAN","GTP-binding protein 10",null,"GTPBP10"]
["15.7999","15.6826","18.1631","17.7249",{"$nulls":3},"cell proliferation;mitochondrial calcium ion transmembrane transport;mitochondrial protein catabolic process;mitochondrial protein processing;mitochondrion organization;negative regulation of apoptotic process;protein hexamerization;protein quality control for misfolded or incompletely synthesized proteins","ATP binding;ATP-dependent peptidase activity;metal ion binding;metalloendopeptidase activity;metallopeptidase activity","integral component of membrane;membrane;mitochondrial inner membrane;mitochondrion;nuclear body",{"$nulls":3},3,3,3,"6.3","6.3","6.3","86.454",0,"72.942",77700000,13,"1.9814","0.413607","-2.20275","-9.7114","sp|Q96TA2|YMEL1_HUMAN;tr|Q96I63|Q96I63_HUMAN","sp|Q96TA2|YMEL1_HUMAN;tr|Q96I63|Q96I63_HUMAN",2365,"Q96TA2","YMEL1_HUMAN","ATP-dependent zinc metalloprotease YME1L1",null,"YME1L1"]
["15.8197","17.1602","18.6688","18.7266",{"$nulls":3},"anterograde axonal transport;antigen processing and presentation of exogenous peptide antigen via MHC class II;microtubule-based movement;mitotic cytokinesis;mitotic spindle midzone assembly;organelle organization;retrograde vesicle-mediated transport, Golgi to ER","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;DNA binding;microtubule binding;microtubule motor activity","axon cytoplasm;chromosome;cytoplasm;cytosol;intercellular bridge;kinesin complex;membrane;midbody;nuclear matrix;nucleoplasm;spindle microtubule",{"$nulls":3},7,7,7,"6.5","6.5","6.5","139.88",0,"48.404",238200000,27,"1.09017","0.310135","-2.20775","-3.2907","sp|O95239|KIF4A_HUMAN;sp|Q2VIQ3|KIF4B_HUMAN","sp|O95239|KIF4A_HUMAN",421,"O95239","KIF4A_HUMAN","Chromosome-associated kinesin KIF4A",null,"KIF4A"]
["12.9211","17.0832","16.9261","17.5221",{"$nulls":3},"7-methylguanosine mRNA capping;RNA processing;transcription from RNA polymerase II promoter;viral process","GTP binding;mRNA guanylyltransferase activity;polynucleotide 5'-phosphatase activity;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity;RNA guanylyltransferase activity;triphosphatase activity","nucleoplasm;nucleus","mRNA surveillance pathway",null,null,3,3,3,"5.4","5.4","5.4","68.556",0,"9.9909",40821000,6,"0.396478","0.622957","-2.22196","-1.05694","sp|O60942|MCE1_HUMAN","sp|O60942|MCE1_HUMAN",315,"O60942","MCE1_HUMAN","mRNA-capping enzyme",null,"RNGTT"]
["12.6916","11.6973","14.6044","14.2479",{"$nulls":3},"acetyl-CoA metabolic process;biotin metabolic process;carnitine shuttle;cellular response to prostaglandin E stimulus;fatty acid biosynthetic process;fatty-acyl-CoA biosynthetic process;lipid homeostasis;malonyl-CoA biosynthetic process;multicellular organismal protein metabolic process;positive regulation of cellular metabolic process;protein homotetramerization;regulation of cholesterol biosynthetic process;tissue homeostasis","acetyl-CoA carboxylase activity;ATP binding;biotin carboxylase activity;identical protein binding;metal ion binding","actin cytoskeleton;cytosol;extracellular exosome;fibrillar center;mitochondrion","AMPK signaling pathway;Fatty acid biosynthesis;Fatty acid metabolism;Glucagon signaling pathway;Insulin signaling pathway;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism",null,null,3,3,3,"2.2","2.2","2.2","265.55","0.00040371","3.4349",26253000,2,"1.28648","0.330051","-2.23168","-4.22545","sp|Q13085|ACACA_HUMAN;tr|Q59FY4|Q59FY4_HUMAN","sp|Q13085|ACACA_HUMAN;tr|Q59FY4|Q59FY4_HUMAN",1518,"Q13085","ACACA_HUMAN","Acetyl-CoA carboxylase 1","CC1","ACACA"]
["14.0405","16.9684","17.5911","17.9081",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosomal small subunit biogenesis;rRNA base methylation;rRNA processing","RNA binding;rRNA (pseudouridine) methyltransferase activity;rRNA binding","cytoplasm;nucleolus;nucleoplasm;nucleus;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,1,1,1,"4.1","4.1","4.1","26.72","0.0020972","2.2401",17730000,0,"0.573775","0.462834","-2.2451","-1.52472","sp|Q92979|NEP1_HUMAN","sp|Q92979|NEP1_HUMAN",2210,"Q92979","NEP1_HUMAN","Ribosomal RNA small subunit methyltransferase NEP1 {ECO:0000305|PubMed:20047967}",null,"EMG1"]
["14.624","15.0469","17.459","16.7241",{"$nulls":3},"intracellular protein transport;toxin transport;vesicle-mediated transport",null,"actin filament;AP-3 adaptor complex;CORVET complex;early endosome",{"$nulls":3},2,2,2,"3.5","3.5","3.5","107.81",0,"9.3497",35144000,6,"1.47445","0.326091","-2.25614","-5.32206","tr|A0A087WXL6|A0A087WXL6_HUMAN;sp|Q9H270|VPS11_HUMAN;tr|A0A0G2JS92|A0A0G2JS92_HUMAN;tr|B7Z879|B7Z879_HUMAN","tr|A0A087WXL6|A0A087WXL6_HUMAN;sp|Q9H270|VPS11_HUMAN;tr|A0A0G2JS92|A0A0G2JS92_HUMAN;tr|B7Z879|B7Z879_HUMAN",2573,"A0A087WXL6","A0A087WXL6_HUMAN"]
["16.2869","16.0458","20.1618","16.6896",{"$nulls":3},"carbohydrate metabolic process;glutathione metabolic process;methylglyoxal metabolic process;negative regulation of apoptotic process;osteoclast differentiation;pyruvate metabolic process;regulation of transcription from RNA polymerase II promoter","lactoylglutathione lyase activity;zinc ion binding","cytoplasm;cytosol;extracellular exosome;nucleus;plasma membrane","Metabolic pathways;Pyruvate metabolism",null,null,2,2,2,"15.2","15.2","15.2","20.777",0,"4.3849",41237000,2,"0.489815","0.521463","-2.25935","-1.29828","sp|Q04760|LGUL_HUMAN","sp|Q04760|LGUL_HUMAN",1446,"Q04760","LGUL_HUMAN","Lactoylglutathione lyase",null,"GLO1"]
["22.5771","19.2484","23.4601","23.0185",{"$nulls":5},"nuclear body",{"$nulls":3},1,1,1,"11.4","11.4","11.4","9.3804",0,"27.407",432710000,7,"0.522719","0.502475","-2.3266","-1.38578","tr|Q5T123|Q5T123_HUMAN;sp|Q9H299|SH3L3_HUMAN;tr|A0A087WV23|A0A087WV23_HUMAN","tr|Q5T123|Q5T123_HUMAN;sp|Q9H299|SH3L3_HUMAN;tr|A0A087WV23|A0A087WV23_HUMAN",2574,"Q5T123","Q5T123_HUMAN",null,null,"SH3BGRL3"]
["14.2599","14.1035","18.6901","14.3292",{"$nulls":3},"protein targeting to peroxisome","ATP binding;ATPase activity, coupled","peroxisomal membrane;peroxisome",{"$nulls":3},2,2,2,2,2,2,"136.58","0.0011282","2.8275",34044000,4,"0.400414","0.621318","-2.32796","-1.06696","tr|A0A0C4DG33|A0A0C4DG33_HUMAN;sp|O43933|PEX1_HUMAN;tr|H7BZH3|H7BZH3_HUMAN","tr|A0A0C4DG33|A0A0C4DG33_HUMAN;sp|O43933|PEX1_HUMAN;tr|H7BZH3|H7BZH3_HUMAN",278,"A0A0C4DG33","A0A0C4DG33_HUMAN"]
["15.6355","14.1189","17.0856","17.3378",{"$nulls":3},"regulation of Rho protein signal transduction","metal ion binding;Rho guanyl-nucleotide exchange factor activity",{"$nulls":4},4,4,4,"6.1","6.1","6.1","129.5",0,"7.0338",23376000,4,"1.02928","0.298616","-2.33442","-3.03677","tr|B7ZM68|B7ZM68_HUMAN;sp|Q6ZNL6|FGD5_HUMAN;tr|H7C0G2|H7C0G2_HUMAN","tr|B7ZM68|B7ZM68_HUMAN;sp|Q6ZNL6|FGD5_HUMAN",1914,"B7ZM68","B7ZM68_HUMAN"]
["16.2258","16.2483","18.7933","18.3925",{"$nulls":9},2,2,2,"3.4","3.4","3.4","78.346",0,"3.8289",78344000,3,"2.14381","0.40672","-2.35585","-11.7369","tr|E9PC74|E9PC74_HUMAN;sp|Q13144|EI2BE_HUMAN","tr|E9PC74|E9PC74_HUMAN;sp|Q13144|EI2BE_HUMAN",1526,"E9PC74"]
["17.4664","17.6006","20.0519","19.7457",{"$nulls":3},"cell division","ATP binding;protein serine/threonine kinase activity","cytosol;nucleus",{"$nulls":3},6,6,5,"22.2","22.2","18.5","34.081",0,"12.916",228610000,23,"2.3047","0.441129","-2.36529","-14.1491","tr|A0A024QZP7|A0A024QZP7_HUMAN;sp|P06493|CDK1_HUMAN;tr|E5RIU6|E5RIU6_HUMAN;tr|A0A087WZZ9|A0A087WZZ9_HUMAN;tr|G3V317|G3V317_HUMAN;tr|K7ELV5|K7ELV5_HUMAN;sp|Q00526|CDK3_HUMAN","tr|A0A024QZP7|A0A024QZP7_HUMAN;sp|P06493|CDK1_HUMAN;tr|E5RIU6|E5RIU6_HUMAN;tr|A0A087WZZ9|A0A087WZZ9_HUMAN",528,"A0A024QZP7","A0A024QZP7_HUMAN",null,null,"CDK1"]
["18.5215","18.7145","20.8939","21.0958",{"$nulls":3},"axon regeneration;dihydrofolate metabolic process;folic acid metabolic process;glycine biosynthetic process;negative regulation of translation;nucleotide biosynthetic process;one-carbon metabolic process;oxidation-reduction process;positive regulation of nitric-oxide synthase activity;regulation of removal of superoxide radicals;regulation of transcription involved in G1/S transition of mitotic cell cycle;response to methotrexate;tetrahydrobiopterin biosynthetic process;tetrahydrofolate biosynthetic process;tetrahydrofolate metabolic process","dihydrofolate reductase activity;drug binding;folate reductase activity;folic acid binding;methotrexate binding;mRNA binding;NADPH binding;sequence-specific mRNA binding;translation repressor activity, nucleic acid binding","cytosol;mitochondrion","Antifolate resistance;Folate biosynthesis;Metabolic pathways;One carbon pool by folate",null,null,3,3,3,"23.5","23.5","23.5","21.452",0,"10.792",176050000,13,"2.4639","0.501183","-2.37685","-17.0148","sp|P00374|DYR_HUMAN;tr|B4DM58|B4DM58_HUMAN","sp|P00374|DYR_HUMAN",464,"P00374","DYR_HUMAN","Dihydrofolate reductase",null,"DHFR"]
["12.8146","12.5998","15.1502","15.1297",{"$nulls":3},"cell differentiation","RNA binding",{"$nulls":4},2,2,2,"1.5","1.5","1.5","242.96",0,"4.371",20971000,9,"2.70749","0.569455","-2.43276","-22.5479","sp|Q5JSZ5|PRC2B_HUMAN;tr|H0Y412|H0Y412_HUMAN","sp|Q5JSZ5|PRC2B_HUMAN;tr|H0Y412|H0Y412_HUMAN",1813,"Q5JSZ5","PRC2B_HUMAN","Protein PRRC2B",null,"PRRC2B"]
["17.2709","17.3292","19.8864","19.5883",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;mitotic cell cycle checkpoint;mitotic sister chromatid segregation;mitotic spindle assembly checkpoint;negative regulation of apoptotic process;negative regulation of mitotic cell cycle;negative regulation of protein catabolic process;negative regulation of ubiquitin protein ligase activity;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;sister chromatid cohesion","identical protein binding;protein homodimerization activity","condensed chromosome kinetochore;cytosol;kinetochore;mitotic spindle;nucleoplasm;nucleus;perinuclear region of cytoplasm;spindle pole","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation",null,null,3,3,3,"15.1","15.1","15.1","23.51",0,"5.4625",94218000,8,"2.41325","0.480211","-2.43727","-16.0459","sp|Q13257|MD2L1_HUMAN","sp|Q13257|MD2L1_HUMAN",1537,"Q13257","MD2L1_HUMAN","Mitotic spindle assembly checkpoint protein MAD2A","sMAD2","MAD2L1"]
["12.5966","12.8634","16.6022","13.7478",{"$nulls":3},"centrosome localization;microtubule anchoring at microtubule organizing center;minus-end-directed organelle transport along microtubule;mRNA transport;protein targeting to Golgi;regulation of microtubule cytoskeleton organization;retrograde vesicle-mediated transport, Golgi to ER","cytoskeletal adaptor activity;dynactin binding;dynein complex binding;dynein light intermediate chain binding;Rab GTPase binding","annulate lamellae;centrosome;cytoplasm;cytoplasmic vesicle;cytosol;Golgi apparatus;nuclear envelope;nuclear pore;plasma membrane",{"$nulls":3},2,2,2,"3.3","3.3","3.3","93.532",0,"4.9845",31167000,3,"0.637916","0.406545","-2.445","-1.70567","sp|Q8TD16|BICD2_HUMAN","sp|Q8TD16|BICD2_HUMAN",2118,"Q8TD16","BICD2_HUMAN","Protein bicaudal D homolog 2","ic-D 2","BICD2"]
["19.179","18.7115","21.5911","21.2675",{"$nulls":3},"cargo loading into vesicle;COPI coating of Golgi vesicle;COPI-coated vesicle budding;COPII vesicle coating;ER to Golgi vesicle-mediated transport;Golgi organization;intracellular protein transport;kidney development;protein oligomerization;regulated exocytosis;regulation of amyloid-beta formation;response to alkaloid;retrograde vesicle-mediated transport, Golgi to ER;vesicle targeting, to, from or within Golgi","protein complex binding;syntaxin binding","cis-Golgi network;COPI-coated vesicle;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;ER to Golgi transport vesicle membrane;extracellular exosome;gamma-secretase complex;Golgi apparatus;Golgi membrane;integral component of membrane;melanosome;plasma membrane;secretory granule membrane;trans-Golgi network transport vesicle;transport vesicle;zymogen granule membrane",{"$nulls":3},4,4,4,"27.9","27.9","27.9","24.976",0,"25.817",212110000,20,"1.89115","0.395062","-2.48401","-8.73694","sp|P49755|TMEDA_HUMAN;tr|G3V2K7|G3V2K7_HUMAN","sp|P49755|TMEDA_HUMAN;tr|G3V2K7|G3V2K7_HUMAN",1091,"P49755","TMEDA_HUMAN","Transmembrane emp24 domain-containing protein 10",null,"TMED10"]
["15.0299","16.7008","19.6487","17.1053",{"$nulls":3},"endocytosis",null,"clathrin coat of endocytic vesicle",{"$nulls":3},2,2,2,"15.2","15.2","15.2","44.888","0.0091503","1.7106",58386000,4,"0.618734","0.42319","-2.51166","-1.65074","tr|F6PQP6|F6PQP6_HUMAN;tr|E9PBC1|E9PBC1_HUMAN;sp|O95208|EPN2_HUMAN;tr|I3L356|I3L356_HUMAN;tr|I3L2H1|I3L2H1_HUMAN;tr|I3L2B2|I3L2B2_HUMAN","tr|F6PQP6|F6PQP6_HUMAN;tr|E9PBC1|E9PBC1_HUMAN;sp|O95208|EPN2_HUMAN;tr|I3L356|I3L356_HUMAN;tr|I3L2H1|I3L2H1_HUMAN;tr|I3L2B2|I3L2B2_HUMAN",417,"F6PQP6","F6PQP6_HUMAN",null,null,"EPN2"]
["16.2531","16.4976","19.0705","18.7113",{"$nulls":3},"apoptotic process;protein localization","actin binding","cytoskeleton;cytosol;focal adhesion",{"$nulls":3},5,5,5,"12.2","12.2","12.2","76.763",0,"13.941",103450000,12,"2.13211","0.404078","-2.51554","-11.5782","sp|Q8IZW8|TENS4_HUMAN","sp|Q8IZW8|TENS4_HUMAN",2031,"Q8IZW8","TENS4_HUMAN","Tensin-4",null,"TNS4"]
["13.9128","13.2979","15.8604","16.5107",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell division;chromosome segregation;microtubule-based movement;mitotic cell cycle;mitotic centrosome separation;mitotic spindle assembly;mitotic spindle organization;regulation of mitotic centrosome separation;retrograde vesicle-mediated transport, Golgi to ER;spindle organization","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;microtubule binding;microtubule motor activity;protein complex binding;protein kinase binding","cytosol;kinesin complex;membrane;microtubule;spindle;spindle pole",{"$nulls":3},3,3,3,"3.4","3.4","3.4","119.16",0,"6.3703",62364000,5,"1.54085","0.318697","-2.58018","-5.76616","sp|P52732|KIF11_HUMAN","sp|P52732|KIF11_HUMAN",1163,"P52732","KIF11_HUMAN","Kinesin-like protein KIF11",null,"KIF11"]
["17.8191","15.8346","19.3486","19.5253",{"$nulls":3},"DNA damage checkpoint;negative regulation of phosphoprotein phosphatase activity",null,"cytoplasm",{"$nulls":3},3,3,3,"17.3","17.3","17.3","31.444",0,"7.5617",48526000,7,"0.920795","0.293837","-2.61009","-2.62007","sp|O75663|TIPRL_HUMAN","sp|O75663|TIPRL_HUMAN",358,"O75663","TIPRL_HUMAN","TIP41-like protein",null,"TIPRL"]
["15.587","15.9872","18.2406","18.5786",{"$nulls":3},"cellular response to UV;mitotic cell cycle;negative regulation of inflammatory response;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of stress-activated MAPK cascade","ATP binding;protein serine/threonine kinase activity","nucleus",{"$nulls":3},2,2,2,"6.5","6.5","6.5","36.085",0,"5.1467",96866000,8,"2.0075","0.403103","-2.62253","-10.0122","sp|Q96KB5|TOPK_HUMAN;tr|E5RFX4|E5RFX4_HUMAN","sp|Q96KB5|TOPK_HUMAN;tr|E5RFX4|E5RFX4_HUMAN",2317,"Q96KB5","TOPK_HUMAN","Lymphokine-activated killer T-cell-originated protein kinase",null,"PBK"]
["17.6176","17.659","20.9098","19.665",{"$nulls":3},"lipid particle organization;neutrophil degranulation;response to unfolded protein;retrograde protein transport, ER to cytosol;ubiquitin-dependent ERAD pathway","lipase binding;lipase inhibitor activity;ubiquitin binding;ubiquitin protein ligase binding","azurophil granule lumen;endoplasmic reticulum;extracellular region;lipid droplet;VCP-NPL4-UFD1 AAA ATPase complex",{"$nulls":3},2,2,2,"6.1","6.1","6.1","52.623",0,"6.6821",166100000,4,"1.29186","0.331077","-2.64909","-4.25387","sp|Q96CS3|FAF2_HUMAN","sp|Q96CS3|FAF2_HUMAN",2250,"Q96CS3","FAF2_HUMAN","FAS-associated factor 2",null,"FAF2"]
["18.3649","17.5819","20.8207","20.5429",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;membrane;nucleoplasm","Ribosome",null,null,2,2,2,"24.2","24.2","24.2","14.515",0,"98.827",50021000,11,"1.64348","0.331847","-2.70839","-6.51986","sp|P25398|RS12_HUMAN","sp|P25398|RS12_HUMAN",796,"P25398","RS12_HUMAN","40S ribosomal protein S12",null,"RPS12"]
["19.78","15.77","20.5233","20.4544",{"$nulls":3},"ER to Golgi vesicle-mediated transport;protein transport;retrograde transport, endosome to Golgi;vesicle docking involved in exocytosis;vesicle fusion;vesicle targeting","cadherin binding;protein-cysteine S-palmitoyltransferase activity;SNAP receptor activity;SNARE binding","apical dendrite;basal dendrite;cytoplasm;cytoplasmic vesicle membrane;cytosol;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment membrane;endosome;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of plasma membrane;mitochondrion;neuronal cell body;SNARE complex;transport vesicle","SNARE interactions in vesicular transport",null,null,4,4,4,"26.3","26.3","26.3","22.417",0,"13.806",175080000,12,"0.510593","0.513295","-2.71388","-1.35336","sp|O15498|YKT6_HUMAN;tr|H7C3K7|H7C3K7_HUMAN","sp|O15498|YKT6_HUMAN",224,"O15498","YKT6_HUMAN","Synaptobrevin homolog YKT6",null,"YKT6"]
["18.0021","14.419","18.9083","19.1574",{"$nulls":9},1,1,1,"4.3","4.3","4.3","29.184",0,"6.1024",39551000,8,"0.590628","0.446241","-2.8223","-1.57153","tr|Q9UF94|Q9UF94_HUMAN;tr|H3BQH3|H3BQH3_HUMAN;sp|Q8TBB5|KLDC4_HUMAN","tr|Q9UF94|Q9UF94_HUMAN;tr|H3BQH3|H3BQH3_HUMAN;sp|Q8TBB5|KLDC4_HUMAN",2112,"Q9UF94","Q9UF94_HUMAN",null,null,"DKFZp434G0522"]
["15.4715","15.1325","18.5507","17.8806",{"$nulls":3},"apoptotic process;regulation of apoptotic process;Rho protein signal transduction;septin cytoskeleton organization;signal transduction","GTP binding;GTPase inhibitor activity;GTP-Rho binding","cytosol",{"$nulls":3},2,2,2,"7.1","7.1","7.1","62.667",0,"9.8048",49515000,10,"1.7903","0.368","-2.91368","-7.7593","sp|Q9BST9|RTKN_HUMAN","sp|Q9BST9|RTKN_HUMAN",2438,"Q9BST9","RTKN_HUMAN","Rhotekin",null,"RTKN"]
["15.1189","14.3319","17.4773","17.8125",{"$nulls":3},"cell cycle;cell division;lymphocyte proliferation;maintenance of DNA methylation;methylation-dependent chromatin silencing;multicellular organism development;pericentric heterochromatin assembly;transcription, DNA-templated","ATP binding;helicase activity","chromosome, centromeric region;nucleus;pericentric heterochromatin",{"$nulls":3},3,3,3,"4.3","4.3","4.3","97.073",0,"43.479",58401000,11,"1.68203","0.343581","-2.91952","-6.82588","sp|Q9NRZ9|HELLS_HUMAN;tr|A0A0B4J1V9|A0A0B4J1V9_HUMAN;tr|A0A087WSW7|A0A087WSW7_HUMAN;tr|F6XU50|F6XU50_HUMAN;tr|B1ALG6|B1ALG6_HUMAN;tr|Q9NW36|Q9NW36_HUMAN","sp|Q9NRZ9|HELLS_HUMAN;tr|A0A0B4J1V9|A0A0B4J1V9_HUMAN;tr|A0A087WSW7|A0A087WSW7_HUMAN;tr|F6XU50|F6XU50_HUMAN",2689,"Q9NRZ9","HELLS_HUMAN","Lymphoid-specific helicase",null,"HELLS"]
["15.5753","15.1036","18.2952","18.5506",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;cellular response to fatty acid;cellular response to hypoxia;cellular response to iron(III) ion;cellular response to organic cyclic compound;digestive tract development;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;G2/M transition of mitotic cell cycle;histone H3-S10 phosphorylation involved in chromosome condensation;in utero embryonic development;mitotic metaphase plate congression;mitotic nuclear envelope disassembly;mitotic spindle organization;negative regulation of gene expression;negative regulation of protein phosphorylation;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;oocyte maturation;positive regulation of attachment of spindle microtubules to kinetochore;positive regulation of cardiac muscle cell proliferation;positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle;positive regulation of fibroblast proliferation;positive regulation of histone phosphorylation;positive regulation of mitochondrial ATP synthesis coupled electron transport;positive regulation of mitotic cell cycle;positive regulation of mRNA 3'-end processing;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;protein complex assembly;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of cell cycle;regulation of chromosome condensation;regulation of mitotic cell cycle spindle assembly checkpoint;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;response to DDT;response to drug;response to mechanical stimulus;spermatogenesis;tissue regeneration;transcription initiation from RNA polymerase II promoter;ventricular cardiac muscle cell development","cyclin-dependent protein serine/threonine kinase activator activity;cyclin-dependent protein serine/threonine kinase activity;histone kinase activity;patched binding;protein kinase binding;ubiquitin-like protein ligase binding","centrosome;condensed nuclear chromosome outer kinetochore;cyclin B1-CDK1 complex;cytoplasm;cytosol;membrane;mitochondrial matrix;nucleoplasm;nucleus;spindle pole","Cell cycle;Cellular senescence;FoxO signaling pathway;Human immunodeficiency virus 1 infection;Oocyte meiosis;p53 signaling pathway;Progesterone-mediated oocyte maturation",null,null,2,2,2,"6.5","6.5","6.5","48.337",0,"17.294",50281000,9,"2.12605","0.397714","-3.0835","-11.4968","sp|P14635|CCNB1_HUMAN;tr|E9PC90|E9PC90_HUMAN","sp|P14635|CCNB1_HUMAN;tr|E9PC90|E9PC90_HUMAN",672,"P14635","CCNB1_HUMAN","G2/mitotic-specific cyclin-B1",null,"CCNB1"]
["15.7434","13.5548","17.7342","17.8105",{"$nulls":3},"DNA replication initiation;DNA replication, synthesis of RNA primer;G1/S transition of mitotic cell cycle;telomere maintenance via semi-conservative replication","4 iron, 4 sulfur cluster binding;DNA primase activity;DNA-directed DNA polymerase activity;metal ion binding;single-stranded DNA binding","alpha DNA polymerase:primase complex;nucleoplasm","DNA replication",null,null,4,4,4,"9.8","9.8","9.8","58.805",0,"6.4646",61091000,7,"0.982682","0.29755","-3.12325","-2.85246","sp|P49643|PRI2_HUMAN","sp|P49643|PRI2_HUMAN",1085,"P49643","PRI2_HUMAN","DNA primase large subunit",null,"PRIM2"]
["16.134","16.5961","19.4868","19.8145",{"$nulls":3},"deoxyribonucleotide biosynthetic process;DNA replication;negative regulation of G0 to G1 transition;nucleobase-containing small molecule interconversion;regulation of transcription involved in G1/S transition of mitotic cell cycle","metal ion binding;ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor","cytosol;ribonucleoside-diphosphate reductase complex","Drug metabolism - other enzymes;Glutathione metabolism;Metabolic pathways;p53 signaling pathway;Purine metabolism;Pyrimidine metabolism",null,null,10,10,10,"29.8","29.8","29.8","44.877",0,"19.515",303700000,21,"2.13381","0.408079","-3.28557","-11.6012","sp|P31350|RIR2_HUMAN;tr|C9JXC1|C9JXC1_HUMAN;tr|A0A0C4DGZ6|A0A0C4DGZ6_HUMAN;sp|Q7LG56|RIR2B_HUMAN;tr|H0YAV1|H0YAV1_HUMAN","sp|P31350|RIR2_HUMAN;tr|C9JXC1|C9JXC1_HUMAN",886,"P31350","RIR2_HUMAN","Ribonucleoside-diphosphate reductase subunit M2",null,"RRM2"]
["13.0818","13.3365","16.8811","16.6618",{"$nulls":3},"actin filament organization;asymmetric neuroblast division;cell morphogenesis;cellular hyperosmotic response;cellular response to muramyl dipeptide;cellular response to tumor necrosis factor;establishment of mitotic spindle orientation;G-protein coupled receptor signaling pathway;innate immune response;intracellular protein transport;intracellular signal transduction;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;negative regulation of microtubule depolymerization;negative regulation of necroptotic process;negative regulation of neurogenesis;negative regulation of podosome assembly;positive regulation of apoptotic process;positive regulation of interleukin-6 production;positive regulation of neuron differentiation;positive regulation of neuron migration;positive regulation of NF-kappaB transcription factor activity;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor production;regulation of cell proliferation;regulation of Rho protein signal transduction;regulation of small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity;microtubule binding;Rac GTPase binding;Rac guanyl-nucleotide exchange factor activity;Rho GTPase binding;Rho guanyl-nucleotide exchange factor activity;transcription factor binding;zinc ion binding","bicellular tight junction;cytoplasm;cytoplasmic vesicle;cytoskeleton;cytosol;dendritic shaft;focal adhesion;Golgi apparatus;microtubule;neuronal cell body;podosome;postsynaptic density;protein complex;ruffle membrane;spindle;vesicle","Fluid shear stress and atherosclerosis;Pathogenic Escherichia coli infection;Tight junction",null,null,2,2,2,"2.4","2.4","2.4","111.54","0.00076307","2.9448",33729000,2,"2.65396","0.594759","-3.56228","-21.1962","sp|Q92974|ARHG2_HUMAN;tr|V9GYM8|V9GYM8_HUMAN;tr|Q5VY93|Q5VY93_HUMAN","sp|Q92974|ARHG2_HUMAN;tr|V9GYM8|V9GYM8_HUMAN;tr|Q5VY93|Q5VY93_HUMAN",2209,"Q92974","ARHG2_HUMAN","Rho guanine nucleotide exchange factor 2",null,"ARHGEF2"]
["14.2973","10.688","16.1394","16.7125",{"$nulls":3},"chromosome separation;female meiosis chromosome segregation;meiotic spindle assembly checkpoint;mitotic spindle assembly checkpoint;mitotic spindle organization;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of cell proliferation;positive regulation of pathway-restricted SMAD protein phosphorylation;protein autophosphorylation;protein localization to kinetochore;protein localization to meiotic spindle midzone;spindle organization","ATP binding;protein homodimerization activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity","cytoplasm;kinetochore;membrane;spindle","Cell cycle",null,null,4,4,4,"7.4","7.4","7.4","97.071",0,"14.384",51408000,9,"0.784533","0.332602","-3.93329","-2.15257","sp|P33981|TTK_HUMAN;tr|D6RF82|D6RF82_HUMAN;tr|D6REX1|D6REX1_HUMAN;tr|D6RIC6|D6RIC6_HUMAN","sp|P33981|TTK_HUMAN",911,"P33981","TTK_HUMAN","Dual specificity protein kinase TTK",null,"TTK"]
["15.2318","12.8172","18.3243","18.8596",{"$nulls":3},"glomerular visceral epithelial cell migration;hematopoietic progenitor cell differentiation;mitotic cytokinesis;positive regulation of bleb assembly;regulation of exit from mitosis;septin ring assembly","actin binding;cadherin binding","actin cytoskeleton;actomyosin contractile ring;bleb;cell cortex region;nucleoplasm",{"$nulls":3},11,11,11,"11.8","11.8","11.8","124.2",0,"50.539",326580000,35,"1.17969","0.319854","-4.56746","-3.69352","sp|Q9NQW6|ANLN_HUMAN;tr|C9JJT6|C9JJT6_HUMAN;tr|H7C3S1|H7C3S1_HUMAN;tr|H7C1K5|H7C1K5_HUMAN","sp|Q9NQW6|ANLN_HUMAN",2672,"Q9NQW6","ANLN_HUMAN","Anillin",null,"ANLN"]
["15.0624",1,"15.9456","12.1301",{"$nulls":3},"adult locomotory behavior;developmental growth;microtubule cytoskeleton organization;mitotic spindle organization;muscle atrophy;peripheral nervous system neuron axonogenesis;post-chaperonin tubulin folding pathway;post-embryonic development;protein folding","chaperone binding","cytoplasm;microtubule",{"$nulls":3},1,1,1,"2.7","2.7","2.7","59.345","0.0047458","1.9871",8494000,1,"0.304213","0.723882","-6.00664","-0.824474","sp|Q15813|TBCE_HUMAN","sp|Q15813|TBCE_HUMAN",1724,"Q15813","TBCE_HUMAN","Tubulin-specific chaperone E",null,"TBCE"]
[1,"16.5207","14.7991","15.1478",{"$nulls":3},"cell migration;lung alveolus development;positive regulation of cell proliferation",null,"cytosol;focal adhesion",{"$nulls":3},3,3,3,"3.7","3.7","3.7","155.26",0,"28.144",44698000,5,"0.294618","0.734922","-6.21314","-0.800424","sp|Q68CZ2|TENS3_HUMAN;tr|E9PCX8|E9PCX8_HUMAN","sp|Q68CZ2|TENS3_HUMAN",1859,"Q68CZ2","TENS3_HUMAN","Tensin-3",null,"TNS3"]
["14.456",1,"15.3291","12.8805",{"$nulls":3},"mitochondrial threonyl-tRNA aminoacylation","aminoacyl-tRNA editing activity;ATP binding;protein homodimerization activity;threonine-tRNA ligase activity","mitochondrial matrix;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,2,2,2,"3.5","3.5","3.5","81.035","0.0003858","3.0483",35510000,2,"0.347248","0.687439","-6.37682","-0.932492","sp|Q9BW92|SYTM_HUMAN;tr|Q5T5E9|Q5T5E9_HUMAN;tr|U3KQ50|U3KQ50_HUMAN;tr|U3KQG0|U3KQG0_HUMAN","sp|Q9BW92|SYTM_HUMAN;tr|Q5T5E9|Q5T5E9_HUMAN;tr|U3KQ50|U3KQ50_HUMAN;tr|U3KQG0|U3KQG0_HUMAN",2482,"Q9BW92","SYTM_HUMAN","Threonine--tRNA ligase, mitochondrial",null,"TARS2"]
["14.4063",1,"14.5315","14.1328",{"$nulls":3},"cellular response to nerve growth factor stimulus;endocytosis;neuron projection development;plasma membrane tubulation;protein localization to endosome;protein targeting to membrane;receptor-mediated endocytosis;retrograde transport, endosome to plasma membrane;slow endocytic recycling","cadherin binding;identical protein binding;metal ion binding;phosphatidic acid binding;Rab GTPase binding","extrinsic component of membrane;late endosome;late endosome membrane;recycling endosome membrane",{"$nulls":3},2,2,2,"3.9","3.9","3.9","93.44","0.0010961","2.587",16137000,4,"0.369468","0.658945","-6.62899","-0.988497","sp|Q8N3F8|MILK1_HUMAN;tr|B0QY86|B0QY86_HUMAN","sp|Q8N3F8|MILK1_HUMAN;tr|B0QY86|B0QY86_HUMAN",2046,"Q8N3F8","MILK1_HUMAN","MICAL-like protein 1",null,"MICALL1"]
[1,"15.0018","14.9663","14.5324",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;rRNA transcription;transcription from RNA polymerase III promoter;transcription initiation from RNA polymerase III promoter;transcription, DNA-templated;tRNA transcription;tRNA transcription from RNA polymerase III promoter","RNA polymerase III type 1 promoter sequence-specific DNA binding;RNA polymerase III type 2 promoter sequence-specific DNA binding;transcription factor activity, RNA polymerase III transcription factor binding","intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;transcription factor TFIIIC complex",{"$nulls":3},1,1,1,"0.8","0.8","0.8","238.87",0,"8.503",21119000,7,"0.359548","0.668862","-6.74839","-0.963466","sp|Q12789|TF3C1_HUMAN","sp|Q12789|TF3C1_HUMAN",1492,"Q12789","TF3C1_HUMAN","General transcription factor 3C polypeptide 1",null,"GTF3C1"]
["14.4169",1,"15.0892","13.9316",{"$nulls":3},"cell migration;regulation of actin cytoskeleton organization","actin binding",{"$nulls":4},1,1,1,"1.6","1.6","1.6","83.381","0.0011074","2.7123",13034000,5,"0.378048","0.645035","-6.80197","-1.01019","tr|H0Y7U8|H0Y7U8_HUMAN;tr|H0Y470|H0Y470_HUMAN;tr|H7C2C6|H7C2C6_HUMAN;sp|Q3V6T2|GRDN_HUMAN","tr|H0Y7U8|H0Y7U8_HUMAN;tr|H0Y470|H0Y470_HUMAN;tr|H7C2C6|H7C2C6_HUMAN;sp|Q3V6T2|GRDN_HUMAN",1781,"H0Y7U8","H0Y7U8_HUMAN",null,null,"CCDC88A"]
[1,"15.1932","15.4869","14.6426",{"$nulls":3},"cell growth;negative regulation of apoptotic process","ATP binding","integral component of membrane;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrion",{"$nulls":3},5,1,0,"13.9","3.6",0,"71.368","0.0011038","2.6709",10285000,3,"0.366168","0.66364","-6.96815","-0.980166","sp|Q9NVI7|ATD3A_HUMAN","sp|Q9NVI7|ATD3A_HUMAN",2722,"Q9NVI7","ATD3A_HUMAN","ATPase family AAA domain-containing protein 3A {ECO:0000312|HGNC:HGNC:25567}",null,"ATAD3A"]
[1,"13.3752","14.8021","13.6011",{"$nulls":3},"phosphatidylinositol biosynthetic process;phosphatidylinositol dephosphorylation;protein dephosphorylation","calcium-activated potassium channel activity;phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;phosphatidylinositol-3,5-bisphosphate phosphatase activity;phosphatidylinositol-3-phosphatase activity;protein serine/threonine phosphatase activity;protein tyrosine phosphatase activity","cytoplasm;cytosol;nuclear envelope","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,1,1,1,"1.9","1.9","1.9","71.967","0.001068","2.3832",6543600,2,"0.424402","0.590411","-7.01398","-1.12826","sp|Q9Y217|MTMR6_HUMAN","sp|Q9Y217|MTMR6_HUMAN",2934,"Q9Y217","MTMR6_HUMAN","Myotubularin-related protein 6",null,"MTMR6"]
[1,"15.2309","15.7871","14.7094",{"$nulls":3},"muscle organ development;positive regulation of histone methylation;positive regulation of myoblast proliferation;positive regulation of transcription from RNA polymerase II promoter;regulation of skeletal muscle satellite cell proliferation;transcription, DNA-templated","DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcription factor binding","cytosol;nucleus",{"$nulls":3},1,1,1,"1.6","1.6","1.6","104.8","0.0010969","2.5909",7026800,3,"0.373852","0.651747","-7.13279","-0.999576","sp|Q9Y5B6|PAXB1_HUMAN","sp|Q9Y5B6|PAXB1_HUMAN",3015,"Q9Y5B6","PAXB1_HUMAN","PAX3- and PAX7-binding protein 1",null,"PAXBP1"]
[1,"16.2935","16.688","14.9618",{"$nulls":3},"mRNA processing;RNA splicing","RNA binding;RNA polymerase core enzyme binding","nuclear matrix;nucleoplasm;spliceosomal complex",{"$nulls":3},3,3,3,"2.8","2.8","2.8","140.52",0,"4.7487",25984000,3,"0.347368","0.687909","-7.17814","-0.932796","sp|Q9UPN6|SCAF8_HUMAN;tr|A0A0A0MT33|A0A0A0MT33_HUMAN","sp|Q9UPN6|SCAF8_HUMAN;tr|A0A0A0MT33|A0A0A0MT33_HUMAN",2920,"Q9UPN6","SCAF8_HUMAN","Protein SCAF8",null,"SCAF8"]
["15.1782",1,"15.683","15.2326",{"$nulls":3},"protein import into nucleus","DNA binding;metal ion binding;protein phosphatase inhibitor activity;RNA binding","chromatin;nuclear body;nucleoplasm;nucleus;PTW/PP1 phosphatase complex",{"$nulls":3},1,1,1,"1.7","1.7","1.7","99.057","0.0003876","3.0983",17059000,1,"0.389385","0.63261","-7.36873","-1.03892","sp|Q96QC0|PP1RA_HUMAN","sp|Q96QC0|PP1RA_HUMAN",2337,"Q96QC0","PP1RA_HUMAN","Serine/threonine-protein phosphatase 1 regulatory subunit 10",null,"PPP1R10"]
[1,"14.6319","15.5459","15.0507",{"$nulls":3},"animal organ morphogenesis;apoptotic process;atrial septum morphogenesis;bone remodeling;cell cycle arrest;cell fate determination;hemopoiesis;marginal zone B cell differentiation;multicellular organism development;negative regulation of apoptotic process;negative regulation of gene expression;negative regulation of growth rate;nervous system development;Notch signaling involved in heart development;Notch signaling pathway;positive regulation of ERK1 and ERK2 cascade;positive regulation of Ras protein signal transduction;pulmonary valve morphogenesis;regulation of developmental process;regulation of transcription, DNA-templated;stem cell population maintenance;transcription initiation from RNA polymerase II promoter","calcium ion binding;receptor activity;transcription factor activity, ligand-activated RNA polymerase II transcription factor binding","cell surface;endoplasmic reticulum membrane;extracellular region;Golgi membrane;integral component of plasma membrane;membrane;nucleoplasm;nucleus;plasma membrane;receptor complex","Breast cancer;Endocrine resistance;Human papillomavirus infection;MicroRNAs in cancer;Notch signaling pathway;Pathways in cancer;Th1 and Th2 cell differentiation;Thyroid hormone signaling pathway",null,null,1,1,1,"0.6","0.6","0.6","265.4","0.0078585","1.7338",10458000,2,"0.412211","0.603027","-7.48234","-1.09704","sp|Q04721|NOTC2_HUMAN","sp|Q04721|NOTC2_HUMAN",1444,"Q04721","NOTC2_HUMAN","Neurogenic locus notch homolog protein 2","N2;otch 2","NOTCH2"]
["14.4146",1,"15.6319","14.7683",{"$nulls":3},"regulation of transcription from RNA polymerase II promoter","translation elongation factor activity","elongin complex",{"$nulls":3},1,1,1,"2.1","2.1","2.1","87.229","0.006002","1.8604",9387700,3,"0.419154","0.595794","-7.49282","-1.1148","tr|A0A024RAC6|A0A024RAC6_HUMAN;sp|Q14241|ELOA1_HUMAN","tr|A0A024RAC6|A0A024RAC6_HUMAN;sp|Q14241|ELOA1_HUMAN",1614,"A0A024RAC6","A0A024RAC6_HUMAN",null,null,"ELOA"]
["13.998",1,"14.7179","15.3165",{"$nulls":3},"cytoplasmic sequestering of transcription factor;double-strand break repair via homologous recombination;replication fork processing","histone binding;transcription corepressor activity","cytoplasm;nuclear body;nuclear replication fork;nucleoplasm",{"$nulls":3},1,1,1,"0.9","0.9","0.9","150.93","0.00038865","3.1114",15334000,7,"0.435042","0.574612","-7.51823","-1.15561","sp|Q96HA7|TONSL_HUMAN","sp|Q96HA7|TONSL_HUMAN",2286,"Q96HA7","TONSL_HUMAN","Tonsoku-like protein",null,"TONSL"]
["16.0442",1,"15.9888","16.2464",{"$nulls":3},"cellular respiration;mitochondrial RNA processing;mRNA processing","protein kinase activity;RNA binding;rRNA binding","mitochondrial nucleoid;mitochondrion;ribonucleoprotein granule",{"$nulls":3},2,2,2,"3.1","3.1","3.1","86.573","0.00038911","3.1176",28389000,6,"0.377818","0.645581","-7.59551","-1.00961","sp|Q7L8L6|FAKD5_HUMAN","sp|Q7L8L6|FAKD5_HUMAN",1937,"Q7L8L6","FAKD5_HUMAN","FAST kinase domain-containing protein 5, mitochondrial",null,"FASTKD5"]
["16.1932",1,"16.4917","16.0029",{"$nulls":3},"creatine metabolic process","ATP binding;creatine kinase activity","extracellular exosome;mitochondrial inner membrane;mitochondrion","Arginine and proline metabolism;Metabolic pathways",null,null,2,1,1,"8.9",5,5,"47.036","0.00076864","3.0052",10231000,2,"0.376628","0.64693","-7.65067","-1.0066","sp|P12532|KCRU_HUMAN","sp|P12532|KCRU_HUMAN",647,"P12532","KCRU_HUMAN","Creatine kinase U-type, mitochondrial",null,"CKMT1A;CKMT1B"]
["15.9016",1,"16.1132","16.0961",{"$nulls":3},"activation of MAPK activity;Fc-epsilon receptor signaling pathway;heart development;I-kappaB kinase/NF-kappaB signaling;JNK cascade;MyD88-dependent toll-like receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway;negative regulation of autophagy;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of protein kinase activity;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway","K63-linked polyubiquitin modification-dependent protein binding;metal ion binding","cytosol;endosome membrane;nucleoplasm;plasma membrane","Epstein-Barr virus infection;Hepatitis B;Herpes simplex virus 1 infection;Human immunodeficiency virus 1 infection;IL-17 signaling pathway;Leishmaniasis;MAPK signaling pathway;Measles;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Osteoclast differentiation;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Yersinia infection",null,null,1,1,1,"2.2","2.2","2.2","76.493",0,"3.829",12380000,1,"0.384783","0.636595","-7.65384","-1.02725","sp|Q9NYJ8|TAB2_HUMAN","sp|Q9NYJ8|TAB2_HUMAN",2750,"Q9NYJ8","TAB2_HUMAN","TGF-beta-activated kinase 1 and MAP3K7-binding protein 2",null,"TAB2"]
[1,"15.0966","16.6563","14.8126",{"$nulls":3},"ribosomal small subunit biogenesis;ribosomal small subunit export from nucleus;rRNA processing",null,"cytosol;EGO complex;late endosome membrane;nucleoplasm;nucleus;preribosome, small subunit precursor",{"$nulls":3},2,2,2,"6.5","6.5","6.5","54.854",0,"9.7756",13511000,4,"0.406037","0.613335","-7.68614","-1.08128","sp|Q96GA3|LTV1_HUMAN","sp|Q96GA3|LTV1_HUMAN",2275,"Q96GA3","LTV1_HUMAN","Protein LTV1 homolog",null,"LTV1"]
[1,"14.1522","15.5053","15.0541",{"$nulls":3},"signal transduction","GTPase activator activity",{"$nulls":4},1,1,1,"2.1","2.1","2.1","85.38","0.001403","2.2736",10074000,4,"0.440921","0.562319","-7.70361","-1.17077","tr|E9PCM6|E9PCM6_HUMAN;tr|E7EQN5|E7EQN5_HUMAN;sp|P98171|RHG04_HUMAN","tr|E9PCM6|E9PCM6_HUMAN;tr|E7EQN5|E7EQN5_HUMAN;sp|P98171|RHG04_HUMAN",1394,"E9PCM6","E9PCM6_HUMAN",null,null,"ARHGAP4"]
[1,"14.4418","15.7425","15.1349",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},2,1,1,4,"2.6","2.6","65.821","0.0072727","1.7907",9734200,2,"0.43176","0.578319","-7.7178","-1.14716","tr|A8MQB8|A8MQB8_HUMAN;tr|G3V0J0|G3V0J0_HUMAN","tr|A8MQB8|A8MQB8_HUMAN;tr|G3V0J0|G3V0J0_HUMAN",3070,"A8MQB8","A8MQB8_HUMAN",null,null,"FMR1"]
[1,"15.9028","15.6118","16.7773",{"$nulls":3},"axon guidance;cell adhesion;interferon-gamma-mediated signaling pathway;MAPK cascade","identical protein binding;Ras guanyl-nucleotide exchange factor activity;virus receptor activity","anchored component of membrane;cell surface;cytosol;external side of plasma membrane;extracellular exosome;extracellular matrix;Golgi membrane;integral component of membrane;membrane;plasma membrane","Cell adhesion molecules (CAMs);Prion diseases",null,null,2,2,2,"2.2","2.2","2.2","94.573","0.00075786","2.8832",24838000,4,"0.388229","0.635294","-7.74313","-1.03599","sp|P13591|NCAM1_HUMAN;tr|A0A087WWD4|A0A087WWD4_HUMAN;tr|A0A0D9SF98|A0A0D9SF98_HUMAN;tr|A0A087WWJ5|A0A087WWJ5_HUMAN;tr|A0A0D9SF30|A0A0D9SF30_HUMAN;tr|A0A087WTF6|A0A087WTF6_HUMAN;tr|A0A087WX77|A0A087WX77_HUMAN;tr|A0A087WV75|A0A087WV75_HUMAN","sp|P13591|NCAM1_HUMAN;tr|A0A087WWD4|A0A087WWD4_HUMAN;tr|A0A0D9SF98|A0A0D9SF98_HUMAN;tr|A0A087WWJ5|A0A087WWJ5_HUMAN;tr|A0A0D9SF30|A0A0D9SF30_HUMAN;tr|A0A087WTF6|A0A087WTF6_HUMAN;tr|A0A087WX77|A0A087WX77_HUMAN;tr|A0A087WV75|A0A087WV75_HUMAN",657,"P13591","NCAM1_HUMAN","Neural cell adhesion molecule 1","CAM-1;-CAM-1","NCAM1"]
[1,"15.3537","16.1422","15.7227",{"$nulls":9},1,1,1,"1.7","1.7","1.7","86.557",0,"8.0977",9482900,3,"0.405608","0.613843","-7.75566","-1.08019","sp|Q5W0V3|F16B1_HUMAN","sp|Q5W0V3|F16B1_HUMAN",1849,"Q5W0V3","F16B1_HUMAN","Protein FAM160B1",null,"FAM160B1"]
[1,"15.5369","16.0513","16.3024",{"$nulls":3},"adaptive immune response;antigen processing and presentation of endogenous peptide antigen via MHC class I;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of peptide antigen via MHC class I;cytosol to ER transport;defense response;peptide transport;protein transport;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;viral process","ADP binding;ATP binding;MHC class I protein binding;MHC class Ib protein binding;peptide antigen binding;peptide transporter activity;peptide-transporting ATPase activity;protein homodimerization activity;TAP1 binding;TAP2 binding","endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;integral component of endoplasmic reticulum membrane;integral component of membrane;membrane;microtubule organizing center;mitochondrion;phagocytic vesicle membrane;TAP complex","ABC transporters;Antigen processing and presentation;Epstein-Barr virus infection;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Phagosome;Primary immunodeficiency",null,null,1,1,1,"1.4","1.4","1.4","87.217",0,"7.0184",18083000,4,"0.408623","0.609858","-7.90838","-1.08788","sp|Q03518|TAP1_HUMAN","sp|Q03518|TAP1_HUMAN",1439,"Q03518","TAP1_HUMAN","Antigen peptide transporter 1","PT1","TAP1"]
["14.3997",1,"15.8372","15.4735",{"$nulls":3},"cell cycle;embryo development;histone deubiquitination;histone H4 acetylation;histone ubiquitination;positive regulation of mitotic cell cycle;positive regulation of transcription, DNA-templated;protein deubiquitination;transcription, DNA-templated;ubiquitin-dependent protein catabolic process","enzyme binding;ligand-dependent nuclear receptor transcription coactivator activity;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;transcription coactivator activity;zinc ion binding","nucleoplasm;SAGA complex",{"$nulls":3},1,1,1,"3.2","3.2","3.2","59.96","0.0011198","2.7758",10095000,1,"0.44719","0.553634","-7.95546","-1.18697","sp|Q9UPT9|UBP22_HUMAN","sp|Q9UPT9|UBP22_HUMAN",2925,"Q9UPT9","UBP22_HUMAN","Ubiquitin carboxyl-terminal hydrolase 22",null,"USP22"]
[1,"14.3076","15.0639","16.2712",{"$nulls":5},"cytosol;plasma membrane",{"$nulls":3},1,1,1,"0.8","0.8","0.8","176.55","0.0010791","2.4366",14770000,2,"0.452012","0.551515","-8.01375","-1.19946","tr|A0A0A0MRB5|A0A0A0MRB5_HUMAN;sp|Q8WXG6|MADD_HUMAN","tr|A0A0A0MRB5|A0A0A0MRB5_HUMAN;sp|Q8WXG6|MADD_HUMAN",2157,"A0A0A0MRB5","A0A0A0MRB5_HUMAN",null,null,"MADD"]
["16.1515",1,"16.9043","16.3035",{"$nulls":3},"fat cell differentiation;lipid transport;positive regulation of sequestering of triglyceride","lipid binding","Golgi apparatus;late endosome membrane;nucleoplasm",{"$nulls":3},1,1,1,"1.6","1.6","1.6","83.642",0,"7.0405",34504000,8,"0.397242","0.623836","-8.02816","-1.05889","sp|Q9BXB4|OSB11_HUMAN","sp|Q9BXB4|OSB11_HUMAN",2494,"Q9BXB4","OSB11_HUMAN","Oxysterol-binding protein-related protein 11","RP-11;SBP-related protein 11","OSBPL11"]
[1,"17.5574","17.7887","16.8275",{"$nulls":4},"5'-nucleotidase activity;metal ion binding",{"$nulls":4},2,2,2,"6.2","6.2","6.2","51.844",0,"38.694",46063000,9,"0.361447","0.667921","-8.02939","-0.968254","sp|Q5TFE4|NT5D1_HUMAN;tr|H0YDA5|H0YDA5_HUMAN","sp|Q5TFE4|NT5D1_HUMAN;tr|H0YDA5|H0YDA5_HUMAN",1840,"Q5TFE4","NT5D1_HUMAN","5'-nucleotidase domain-containing protein 1",null,"NT5DC1"]
[1,"17.4897","18.1441","16.4125",{"$nulls":3},"actin cytoskeleton organization;axon guidance;ossification;positive regulation of osteoblast differentiation;receptor-mediated endocytosis","metal ion binding","actin cytoskeleton;cell-cell adherens junction;cytosol;focal adhesion;nucleus;ruffle;stress fiber",{"$nulls":3},2,2,2,"11.2","11.2","11.2","49.844",0,"9.3919",59406000,16,"0.361758","0.667193","-8.0335","-0.969039","sp|Q9NR12|PDLI7_HUMAN","sp|Q9NR12|PDLI7_HUMAN",2676,"Q9NR12","PDLI7_HUMAN","PDZ and LIM domain protein 7",null,"PDLIM7"]
["15.7431",1,"17.1617","15.6592",{"$nulls":3},"adherens junction organization;axon guidance;cell adhesion;cell recognition;cell-cell adhesion;desmosome organization;enamel mineralization;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;homophilic cell adhesion via plasma membrane adhesion molecules;immune response;iron ion transport;lens morphogenesis in camera-type eye;protein localization to cell junction;regulation of synapse assembly;retina development in camera-type eye;viral entry into host cell","carbohydrate binding;cell adhesion molecule binding;coreceptor activity;identical protein binding;protein heterodimerization activity;protein homodimerization activity;receptor binding;virion binding;virus receptor activity","adherens junction;apical junction complex;axon;catenin complex;cell-cell adherens junction;cell-cell contact zone;extracellular region;growth cone membrane;integral component of membrane;integral component of plasma membrane;intracellular membrane-bounded organelle;membrane;plasma membrane;presynaptic membrane","Adherens junction;Cell adhesion molecules (CAMs);Herpes simplex virus 1 infection",null,null,1,1,1,"5.4","5.4","5.4","57.157",0,"3.77",7912500,1,"0.40746","0.610326","-8.0389","-1.08491","sp|Q15223|PVRL1_HUMAN","sp|Q15223|PVRL1_HUMAN",1684,"Q15223","NECT1_HUMAN","Nectin-1",null,"NECTIN1"]
["14.2072",1,"16.301","15.0439",{"$nulls":3},"autophagosome assembly;autophagy of mitochondrion;autophagy of nucleus;macroautophagy;protein lipidation;protein lipidation involved in autophagosome assembly;protein localization to phagophore assembly site;xenophagy","phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-3-phosphate binding;phosphatidylinositol-5-phosphate binding","cytosol;extrinsic component of membrane;phagophore assembly site;phagophore assembly site membrane;protein complex","Autophagy - animal;Autophagy - other",null,null,1,1,1,7,7,7,"49.408","0.0031034","2.1294",9315200,1,"0.458531","0.544569","-8.06884","-1.21638","sp|Q9Y4P8|WIPI2_HUMAN","sp|Q9Y4P8|WIPI2_HUMAN",3006,"Q9Y4P8","WIPI2_HUMAN","WD repeat domain phosphoinositide-interacting protein 2","IPI-2","WIPI2"]
[1,"16.8781","17.7757","16.3697",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic mitochondrial changes;establishment of protein localization to membrane;extrinsic apoptotic signaling pathway via death domain receptors;hepatocyte apoptotic process;mitochondrial ATP synthesis coupled electron transport;mitochondrial outer membrane permeabilization;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;neuron apoptotic process;positive regulation of apoptotic process;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of fibroblast apoptotic process;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial membrane potential;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of protein homooligomerization;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;positive regulation of protein oligomerization;positive regulation of release of cytochrome c from mitochondria;protein homooligomerization;protein targeting to mitochondrion;regulation of apoptotic process;regulation of cell proliferation;regulation of G1/S transition of mitotic cell cycle;release of cytochrome c from mitochondria;signal transduction in response to DNA damage","death receptor binding;protein heterodimerization activity;ubiquitin protein ligase binding","cytosol;extracellular exosome;integral component of mitochondrial membrane;membrane;mitochondrial outer membrane;mitochondrion","Alzheimer disease;Amyotrophic lateral sclerosis (ALS);Apoptosis;Apoptosis - multiple species;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;Natural killer cell mediated cytotoxicity;Necroptosis;Non-alcoholic fatty liver disease (NAFLD);p53 signaling pathway;Pathways in cancer;Platinum drug resistance;Sphingolipid signaling pathway;Tuberculosis;Viral myocarditis",null,null,1,1,1,"6.7","6.7","6.7","21.994","0.0011144","2.7521",10678000,2,"0.382129","0.638989","-8.13369","-1.02052","sp|P55957|BID_HUMAN","sp|P55957|BID_HUMAN",1218,"P55957","BID_HUMAN","BH3-interacting domain death agonist",null,"BID"]
["16.1757",1,"17.0778","16.5891",{"$nulls":3},"protein complex assembly;signaling","protein domain specific binding","plasma membrane;synapse",{"$nulls":3},2,2,2,"3.3","3.3","3.3","108.01",0,"10.498",43195000,6,"0.407931","0.610272","-8.24557","-1.08612","sp|Q9Y2H0|DLGP4_HUMAN;tr|F8WF49|F8WF49_HUMAN;tr|A0A0B4J2C2|A0A0B4J2C2_HUMAN","sp|Q9Y2H0|DLGP4_HUMAN;tr|F8WF49|F8WF49_HUMAN;tr|A0A0B4J2C2|A0A0B4J2C2_HUMAN",2949,"Q9Y2H0","DLGP4_HUMAN","Disks large-associated protein 4","AP-4","DLGAP4"]
["18.1815",1,"17.6559","18.0364",{"$nulls":3},"cell cycle arrest;fatty acid biosynthetic process;macroautophagy;nail development;positive regulation of gene expression;protein heterooligomerization;protein phosphorylation;regulation of catalytic activity;regulation of macroautophagy;regulation of signal transduction by p53 class mediator;signal transduction","AMP-activated protein kinase activity;protein kinase activity;protein kinase binding","cytosol;nucleoplasm;nucleotide-activated protein kinase complex","Adipocytokine signaling pathway;AMPK signaling pathway;Apelin signaling pathway;Circadian rhythm;FoxO signaling pathway;Glucagon signaling pathway;Hypertrophic cardiomyopathy (HCM);Insulin resistance;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Non-alcoholic fatty liver disease (NAFLD);Oxytocin signaling pathway;Thermogenesis;Tight junction",null,null,1,1,1,"11.1","11.1","11.1","30.382",0,"19.397",28418000,2,"0.358464","0.671685","-8.25542","-0.960733","sp|Q9Y478|AAKB1_HUMAN","sp|Q9Y478|AAKB1_HUMAN",2992,"Q9Y478","AAKB1_HUMAN","5'-AMP-activated protein kinase subunit beta-1","MPK subunit beta-1;MPKb","PRKAB1"]
[1,"17.4993","18.6341","16.459",{"$nulls":9},1,1,1,"36.7","36.7","36.7","5.5393",0,"3.456",7041200,1,"0.372871","0.651592","-8.29688","-0.997096","tr|I3L0Q0|I3L0Q0_HUMAN;tr|I3L2Q4|I3L2Q4_HUMAN;sp|P62253|UB2G1_HUMAN","tr|I3L0Q0|I3L0Q0_HUMAN;tr|I3L2Q4|I3L2Q4_HUMAN;sp|P62253|UB2G1_HUMAN",1295,"I3L0Q0","I3L0Q0_HUMAN",null,null,"UBE2G1"]
["15.8295",1,"16.6409","16.7866",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;metal ion binding","nucleus",{"$nulls":3},1,1,1,"0.5","0.5","0.5","187.88","0.0066401","1.8297",57961000,1,"0.420868","0.59371","-8.29897","-1.11919","sp|P52746|ZN142_HUMAN","sp|P52746|ZN142_HUMAN",1164,"P52746","ZN142_HUMAN","Zinc finger protein 142",null,"ZNF142"]
[1,"16.3252","17.3296","16.6324",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;intracellular protein transport;regulation of defense response to virus by virus;vesicle-mediated transport","protein transporter activity","AP-type membrane coat adaptor complex;clathrin-coated endocytic vesicle membrane;clathrin-coated pit;cytoplasmic vesicle membrane;cytosol;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle;lysosomal membrane;trans-Golgi network membrane","Human immunodeficiency virus 1 infection;Lysosome",null,null,1,1,1,"10.2","10.2","10.2","18.615","0.00039246","3.2037",10640000,3,"0.407282","0.610999","-8.31837","-1.08446","sp|P56377|AP1S2_HUMAN","sp|P56377|AP1S2_HUMAN",1223,"P56377","AP1S2_HUMAN","AP-1 complex subunit sigma-2",null,"AP1S2"]
["16.9992",1,"17.5781","17.128",{"$nulls":3},"membrane biogenesis;phosphatidylserine metabolic process;phospholipid biosynthetic process;positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity;positive regulation of serine C-palmitoyltransferase activity;sphingolipid metabolic process","enzyme binding;L-serine transmembrane transporter activity;protein binding, bridging","endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;plasma membrane",{"$nulls":3},1,1,1,"2.9","2.9","2.9","50.494",0,"3.7362",16958000,1,"0.391313","0.630528","-8.35342","-1.04382","sp|Q9NRX5|SERC1_HUMAN","sp|Q9NRX5|SERC1_HUMAN",2688,"Q9NRX5","SERC1_HUMAN","Serine incorporator 1",null,"SERINC1"]
[1,"15.7543","16.5212","16.9531",{"$nulls":3},"canonical Wnt signaling pathway","beta-catenin binding;transcription coactivator activity","nucleolus;nucleoplasm",{"$nulls":3},1,1,1,"0.8","0.8","0.8","153.09","0.0010933","2.546",12706000,1,"0.426151","0.588132","-8.36001","-1.13274","tr|A0A087WZX0|A0A087WZX0_HUMAN;sp|Q86UU0|BCL9L_HUMAN","tr|A0A087WZX0|A0A087WZX0_HUMAN;sp|Q86UU0|BCL9L_HUMAN",1981,"A0A087WZX0","A0A087WZX0_HUMAN",null,null,"BCL9L"]
[1,"14.358","16.2464","15.8485",{"$nulls":3},"rRNA processing;spliceosomal snRNP assembly",null,"cytosol;nuclear body;SMN complex",{"$nulls":3},1,1,1,"1.1","1.1","1.1","118.82",0,"7.0184",19485000,3,"0.472344","0.532642","-8.36849","-1.2524","tr|I3L2C7|I3L2C7_HUMAN;sp|P57678|GEMI4_HUMAN","tr|I3L2C7|I3L2C7_HUMAN;sp|P57678|GEMI4_HUMAN",1228,"I3L2C7","I3L2C7_HUMAN",null,null,"GEMIN4"]
["16.8957",1,"17.8089","16.8267",{"$nulls":3},"astrocyte development;cell cycle arrest;cell dedifferentiation;cell division;cellular response to phorbol 13-acetate 12-myristate;dentate gyrus development;G1/S transition of mitotic cell cycle;generation of neurons;gliogenesis;lateral ventricle development;negative regulation of cell cycle;negative regulation of cell differentiation;negative regulation of cell proliferation;negative regulation of cellular senescence;negative regulation of epithelial cell proliferation;negative regulation of monocyte differentiation;negative regulation of myeloid cell differentiation;negative regulation of osteoblast differentiation;positive regulation of cell-matrix adhesion;positive regulation of fibroblast proliferation;protein phosphorylation;regulation of cell motility;regulation of erythrocyte differentiation;regulation of G2/M transition of mitotic cell cycle;regulation of gene expression;response to virus;signal transduction;type B pancreatic cell development","ATP binding;cyclin binding;cyclin-dependent protein serine/threonine kinase activity;FBXO family protein binding","centrosome;cyclin-dependent protein kinase holoenzyme complex;cytoplasm;cytosol;nucleoplasm;nucleus;ruffle","Breast cancer;Cell cycle;Cellular senescence;Chronic myeloid leukemia;Cushing syndrome;Epstein-Barr virus infection;Glioma;Hepatitis C;Hepatocellular carcinoma;Human cytomegalovirus infection;Human papillomavirus infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;Melanoma;MicroRNAs in cancer;Non-small cell lung cancer;p53 signaling pathway;Pancreatic cancer;Pathways in cancer;PI3K-Akt signaling pathway;Small cell lung cancer;Viral carcinogenesis",null,null,2,2,2,"8.3","8.3","8.3","36.938","0.0047281","1.946",22570000,1,"0.394183","0.623552","-8.36997","-1.05111","sp|Q00534|CDK6_HUMAN","sp|Q00534|CDK6_HUMAN",1403,"Q00534","CDK6_HUMAN","Cyclin-dependent kinase 6",null,"CDK6"]
["17.4474",1,"17.7866","17.5799",{"$nulls":9},1,1,1,"8.6","8.6","8.6","26.758",0,"3.6896",11523000,3,"0.385314","0.634511","-8.45954","-1.0286","tr|H0YE34|H0YE34_HUMAN;tr|A0A075B6T1|A0A075B6T1_HUMAN;sp|Q9C0C7|AMRA1_HUMAN","tr|H0YE34|H0YE34_HUMAN;tr|A0A075B6T1|A0A075B6T1_HUMAN;sp|Q9C0C7|AMRA1_HUMAN",2531,"H0YE34","H0YE34_HUMAN",null,null,"AMBRA1"]
["17.7555",1,"18.2373","17.4474",{"$nulls":3},"protein prenylation","protein prenyltransferase activity",{"$nulls":4},2,2,2,"9.2","9.2","9.2","27.443","0.0056818","1.8759",24499000,3,"0.377675","0.645519","-8.46462","-1.00925","tr|B3KVN2|B3KVN2_HUMAN;tr|E9PQP6|E9PQP6_HUMAN;sp|P49354|FNTA_HUMAN","tr|B3KVN2|B3KVN2_HUMAN;tr|E9PQP6|E9PQP6_HUMAN;sp|P49354|FNTA_HUMAN",1072,"B3KVN2","B3KVN2_HUMAN"]
["16.5327",1,"17.3206","17.472",{"$nulls":9},1,1,1,"5.7","5.7","5.7","27.637",0,"10.79",17013000,6,"0.417725","0.59885","-8.62995","-1.11115","tr|C9J2Z9|C9J2Z9_HUMAN;sp|O15047|SET1A_HUMAN","tr|C9J2Z9|C9J2Z9_HUMAN;sp|O15047|SET1A_HUMAN",194,"C9J2Z9","C9J2Z9_HUMAN",null,null,"SETD1A"]
["16.4783",1,"17.5919","17.2173",{"$nulls":3},"negative regulation of protein K48-linked ubiquitination;positive regulation of cytokine-mediated signaling pathway;positive regulation of defense response to virus by host;positive regulation of NIK/NF-kappaB signaling;positive regulation of transcription, DNA-templated;protein stabilization;regulation of gene expression","zinc ion binding","intracellular",{"$nulls":3},1,1,1,"3.8","3.8","3.8","38.472",0,"5.7856",13434000,2,"0.420932","0.593803","-8.66543","-1.11936","sp|Q96DX7|TRI44_HUMAN","sp|Q96DX7|TRI44_HUMAN",2258,"Q96DX7","TRI44_HUMAN","Tripartite motif-containing protein 44",null,"TRIM44"]
[1,"17.8701","18.3015","17.9631",{"$nulls":3},"miRNA loading onto RISC involved in gene silencing by miRNA;pre-miRNA processing;production of siRNA involved in RNA interference;regulation of viral transcription","double-stranded RNA binding;siRNA binding","RISC complex",{"$nulls":3},1,1,1,17,17,17,"9.3606","0.0072775","1.7993",13165000,0,"0.386211","0.633548","-8.69721","-1.03087","tr|F8VYK6|F8VYK6_HUMAN;tr|F8VZZ7|F8VZZ7_HUMAN;tr|F8VTT7|F8VTT7_HUMAN;tr|F8VP94|F8VP94_HUMAN;tr|F8VYK3|F8VYK3_HUMAN;tr|F8VZ57|F8VZ57_HUMAN;sp|Q15633|TRBP2_HUMAN","tr|F8VYK6|F8VYK6_HUMAN;tr|F8VZZ7|F8VZZ7_HUMAN;tr|F8VTT7|F8VTT7_HUMAN;tr|F8VP94|F8VP94_HUMAN;tr|F8VYK3|F8VYK3_HUMAN;tr|F8VZ57|F8VZ57_HUMAN;sp|Q15633|TRBP2_HUMAN",1709,"F8VYK6","F8VYK6_HUMAN",null,null,"TARBP2"]
["12.5554",1,"15.923","15.1301",{"$nulls":3},"heterochromatin maintenance;regulation of chromosome organization;RNA processing","chromatin binding;DNA binding;RNA binding;RNA polymerase binding","chromosome, centromeric region;cytoplasm;nucleoplasm",{"$nulls":3},2,2,2,3,3,3,"125.97",0,"6.192",20667000,6,"0.568692","0.468212","-8.74885","-1.5107","sp|O75717|WDHD1_HUMAN","sp|O75717|WDHD1_HUMAN",363,"O75717","WDHD1_HUMAN","WD repeat and HMG-box DNA-binding protein 1",null,"WDHD1"]
[1,"16.9296","17.9183","17.7494",{"$nulls":3},"peptidyl-serine octanoylation","O-acyltransferase activity;serine O-acyltransferase activity","endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane",{"$nulls":3},1,1,1,"2.8","2.8","2.8","49.715","0.00076482","2.9739",20236000,5,"0.418631","0.598037","-8.86903","-1.11347","sp|Q96T53|MBOA4_HUMAN","sp|Q96T53|MBOA4_HUMAN",2362,"Q96T53","MBOA4_HUMAN","Ghrelin O-acyltransferase",null,"MBOAT4"]
["18.1064",1,"18.328","18.5715",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"5.3","5.3","5.3","21.233","0.0094648","1.6958",26502000,1,"0.389828","0.633064","-8.8966","-1.04005","tr|A0A0A6YYA0|A0A0A6YYA0_HUMAN;sp|Q9Y3B3|TMED7_HUMAN","tr|A0A0A6YYA0|A0A0A6YYA0_HUMAN;sp|Q9Y3B3|TMED7_HUMAN",2979,"A0A0A6YYA0","A0A0A6YYA0_HUMAN",null,null,"TMED7-TICAM2"]
[1,"15.1585","16.7259","17.2813",{"$nulls":3},"cell division;microtubule-based movement;mitotic metaphase plate congression;mitotic sister chromatid segregation;mitotic spindle assembly;spermatogenesis","ATP binding;ATPase activity;microtubule binding;microtubule motor activity","early endosome;kinesin complex;membrane;microtubule;microtubule organizing center;nucleus;spindle",{"$nulls":3},1,1,1,"1.9","1.9","1.9","73.747",0,"30.663",35400000,8,"0.475121","0.52941","-8.92436","-1.25967","sp|Q9BW19|KIFC1_HUMAN","sp|Q9BW19|KIFC1_HUMAN",2477,"Q9BW19","KIFC1_HUMAN","Kinesin-like protein KIFC1",null,"KIFC1"]
[1,"14.47","15.6349","17.7345",{"$nulls":3},"cell separation after cytokinesis;endosomal transport;ESCRT III complex disassembly;exit from mitosis;late endosome to vacuole transport;mitotic metaphase plate congression;multivesicular body assembly;nuclear envelope reassembly;nucleus organization;protein localization to chromatin;viral budding via host ESCRT complex;viral life cycle","protein transporter activity","cytosol;ESCRT III complex;nuclear envelope;nucleus","Endocytosis;Necroptosis",null,null,2,2,2,"4.6","4.6","4.6","50.91","0.0053745","1.908",20256000,1,"0.495383","0.516775","-8.94972","-1.31299","sp|Q8WUX9|CHMP7_HUMAN","sp|Q8WUX9|CHMP7_HUMAN",2142,"Q8WUX9","CHMP7_HUMAN","Charged multivesicular body protein 7",null,"CHMP7"]
[1,"12.0749","15.659","15.4096",{"$nulls":3},"androgen receptor signaling pathway;cell cycle arrest;cell cycle checkpoint;cell division;cell morphogenesis involved in neuron differentiation;cellular response to xenobiotic stimulus;chromatin remodeling;covalent chromatin modification;digestive tract development;enucleate erythrocyte differentiation;G1/S transition of mitotic cell cycle;glial cell apoptotic process;hepatocyte apoptotic process;maintenance of mitotic sister chromatid cohesion;mitotic cell cycle checkpoint;myoblast differentiation;negative regulation of DNA binding transcription factor activity;negative regulation of epithelial cell proliferation;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of gene expression;negative regulation of protein kinase activity;negative regulation of smoothened signaling pathway;negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle;negative regulation of transcription involved in G1/S transition of mitotic cell cycle;negative regulation of transcription, DNA-templated;neuron apoptotic process;neuron maturation;neuron projection development;positive regulation of macrophage differentiation;positive regulation of mitotic metaphase/anaphase transition;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription regulatory region DNA binding;positive regulation of transcription, DNA-templated;protein localization to chromosome, centromeric region;Ras protein signal transduction;regulation of cell growth;regulation of centromere complex assembly;regulation of cohesin loading;regulation of lipid kinase activity;regulation of mitotic cell cycle;regulation of transcription involved in G1/S transition of mitotic cell cycle;regulation of transcription, DNA-templated;sister chromatid biorientation;skeletal muscle cell differentiation;striated muscle cell differentiation;tissue homeostasis;transcription, DNA-templated;viral process","androgen receptor binding;core promoter binding;disordered domain specific binding;DNA binding;DNA binding transcription factor activity;identical protein binding;importin-alpha family protein binding;kinase binding;phosphoprotein binding;RNA polymerase II activating transcription factor binding;transcription coactivator activity;transcription factor binding;ubiquitin protein ligase binding","chromatin;nucleoplasm;nucleus;PML body;Rb-E2F complex;spindle;SWI/SNF complex","Bladder cancer;Breast cancer;Cell cycle;Cellular senescence;Chronic myeloid leukemia;Cushing syndrome;Endocrine resistance;Epstein-Barr virus infection;Gastric cancer;Glioma;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Melanoma;Non-small cell lung cancer;Pancreatic cancer;Pathways in cancer;Prostate cancer;Small cell lung cancer;Viral carcinogenesis",null,null,2,2,2,"3.6","3.6","3.6","106.16",0,"6.3158",21188000,4,"0.609412","0.428537","-8.9968","-1.6243","sp|P06400|RB_HUMAN","sp|P06400|RB_HUMAN",526,"P06400","RB_HUMAN","Retinoblastoma-associated protein",null,"RB1"]
["18.6584",1,"19.4981","18.1588",{"$nulls":3},"adaptive immune response;complement activation, classical pathway;innate immune response;interleukin-10 production;negative regulation of gene expression;positive regulation of gene expression;positive regulation of interleukin-10 production;positive regulation of memory T cell differentiation;positive regulation of regulatory T cell differentiation;positive regulation of T cell proliferation;positive regulation of transforming growth factor beta production;regulation of complement activation;regulation of Notch signaling pathway;sequestering of extracellular ligand from receptor;single fertilization;T cell mediated immunity","cadherin binding;receptor activity;virus receptor activity","cell surface;extracellular exosome;focal adhesion;inner acrosomal membrane;integral component of plasma membrane;plasma membrane","Complement and coagulation cascades;Measles",null,null,2,2,2,"4.6","4.6","4.6","43.747","0.0014035","2.2789",61691000,2,"0.380478","0.641305","-8.99924","-1.01634","sp|P15529|MCP_HUMAN","sp|P15529|MCP_HUMAN",685,"P15529","MCP_HUMAN","Membrane cofactor protein",null,"CD46"]
[1,"18.5382","18.8855","18.6777",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"6.6","6.6","6.6","18.97",0,"4.4341",16012000,2,"0.384957","0.63575","-9.01254","-1.02769","tr|S4R468|S4R468_HUMAN;sp|Q8NE86|MCU_HUMAN","tr|S4R468|S4R468_HUMAN;sp|Q8NE86|MCU_HUMAN",2093,"S4R468","S4R468_HUMAN",null,null,"MCU"]
["17.9392",1,"19.1498","17.9702",{"$nulls":3},"protein folding","peptidyl-prolyl cis-trans isomerase activity",{"$nulls":4},1,1,1,"17.2","17.2","17.2","15.35",0,"16.099",12315000,6,"0.401886","0.621399","-9.09042","-1.07071","tr|R4GN99|R4GN99_HUMAN;sp|P30405|PPIF_HUMAN","tr|R4GN99|R4GN99_HUMAN;sp|P30405|PPIF_HUMAN",869,"R4GN99","R4GN99_HUMAN","Peptidyl-prolyl cis-trans isomerase {ECO:0000256|RuleBase:RU363019}","PIase {ECO:0000256|RuleBase:RU363019}","PPIF"]
[1,"19.2078","19.6055","18.8493",{"$nulls":3},"fatty-acyl-CoA biosynthetic process;monounsaturated fatty acid biosynthetic process;unsaturated fatty acid biosynthetic process","metal ion binding;oxidoreductase activity;stearoyl-CoA 9-desaturase activity","endoplasmic reticulum membrane;integral component of membrane","AMPK signaling pathway;Biosynthesis of unsaturated fatty acids;Fatty acid metabolism;Metabolic pathways;PPAR signaling pathway",null,null,1,1,1,"5.5","5.5","5.5","37.61",0,"39.942",70362000,6,"0.374528","0.650122","-9.12347","-1.00129","sp|Q86SK9|SCD5_HUMAN","sp|Q86SK9|SCD5_HUMAN",1968,"Q86SK9","SCD5_HUMAN","Stearoyl-CoA desaturase 5 {ECO:0000305}",null,"SCD5"]
["13.2956",1,"16.568","16.0573",{"$nulls":3},"intracellular receptor signaling pathway;negative regulation of cell growth;wound healing",null,"cell surface;integral component of plasma membrane",{"$nulls":3},1,1,1,"1.5","1.5","1.5","85.034","0.0031077","2.1371",5788200,1,"0.560964","0.471672","-9.16482","-1.48946","sp|Q96PD2|DCBD2_HUMAN","sp|Q96PD2|DCBD2_HUMAN",2333,"Q96PD2","DCBD2_HUMAN","Discoidin, CUB and LCCL domain-containing protein 2",null,"DCBLD2"]
[1,"18.7342","19.2313","18.8756",{"$nulls":3},"cellular response to DNA damage stimulus;protein de-ADP-ribosylation;purine nucleoside metabolic process","deacetylase activity;hydrolase activity, acting on glycosyl bonds","mitochondrion;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"7.1","7.1","7.1","35.505",0,"4.413",50334000,4,"0.388154","0.634839","-9.18636","-1.0358","sp|Q9BQ69|MACD1_HUMAN","sp|Q9BQ69|MACD1_HUMAN",2415,"Q9BQ69","MACD1_HUMAN","O-acetyl-ADP-ribose deacetylase MACROD1",null,"MACROD1"]
["18.6583",1,"19.5881","18.4817",{"$nulls":5},"cytosol;nucleus",{"$nulls":3},1,1,1,"22.7","22.7","22.7","8.7797",0,"57.576",22387000,6,"0.390053","0.633121","-9.20578","-1.04062","tr|C9JRU6|C9JRU6_HUMAN;tr|C9J0B2|C9J0B2_HUMAN;tr|C9JUW4|C9JUW4_HUMAN;tr|C9J8R4|C9J8R4_HUMAN;tr|C9JVE2|C9JVE2_HUMAN;sp|Q96GG9|DCNL1_HUMAN","tr|C9JRU6|C9JRU6_HUMAN;tr|C9J0B2|C9J0B2_HUMAN;tr|C9JUW4|C9JUW4_HUMAN;tr|C9J8R4|C9J8R4_HUMAN;tr|C9JVE2|C9JVE2_HUMAN;sp|Q96GG9|DCNL1_HUMAN",2280,"C9JRU6","C9JRU6_HUMAN","DCN1-like protein {ECO:0000256|RuleBase:RU363131}",null,"DCUN1D1"]
[1,"18.3794","19.4775","18.3206",{"$nulls":9},1,1,1,25,25,25,"7.6896","0.005678","1.8755",17187000,2,"0.396681","0.623462","-9.20934","-1.05746","tr|H3BR38|H3BR38_HUMAN;tr|H3BM50|H3BM50_HUMAN;tr|H3BPU5|H3BPU5_HUMAN;tr|H3BR25|H3BR25_HUMAN;tr|H3BPT1|H3BPT1_HUMAN;tr|H3BN58|H3BN58_HUMAN;tr|H3BSZ4|H3BSZ4_HUMAN;sp|Q9BVC4|LST8_HUMAN;tr|A0A0A0MR05|A0A0A0MR05_HUMAN","tr|H3BR38|H3BR38_HUMAN;tr|H3BM50|H3BM50_HUMAN;tr|H3BPU5|H3BPU5_HUMAN;tr|H3BR25|H3BR25_HUMAN;tr|H3BPT1|H3BPT1_HUMAN;tr|H3BN58|H3BN58_HUMAN;tr|H3BSZ4|H3BSZ4_HUMAN;sp|Q9BVC4|LST8_HUMAN;tr|A0A0A0MR05|A0A0A0MR05_HUMAN",2470,"H3BR38","H3BR38_HUMAN",null,null,"MLST8"]
["16.8887",1,"18.4619","17.8726",{"$nulls":3},"rRNA processing;rRNA transcription","RNA binding","actin cytoskeleton;cytosol;nucleolus",{"$nulls":3},1,1,1,9,9,9,"19.343",0,"13.831",9351100,3,"0.436801","0.568771","-9.22289","-1.16014","sp|O75607|NPM3_HUMAN","sp|O75607|NPM3_HUMAN",354,"O75607","NPM3_HUMAN","Nucleoplasmin-3",null,"NPM3"]
["19.2902",1,"19.5409","19.364",{"$nulls":5},"Golgi apparatus;integral component of membrane;nucleoplasm",{"$nulls":3},1,1,1,"1.9","1.9","1.9","63.984","0.005998","1.8599",81559000,4,"0.381011","0.641258","-9.30734","-1.01769","tr|G5E994|G5E994_HUMAN;sp|Q5VW38|GP107_HUMAN","tr|G5E994|G5E994_HUMAN;sp|Q5VW38|GP107_HUMAN",1847,"G5E994","G5E994_HUMAN"]
[1,"17.8991","18.8911","18.6396",{"$nulls":3},"dGTP catabolic process;DNA protection;exogenous drug catabolic process;mitotic cell cycle;nucleobase-containing small molecule catabolic process;nucleoside phosphate catabolic process;purine nucleotide catabolic process;regulation of proteasomal protein catabolic process","8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;metal ion binding;NADH pyrophosphatase activity;nucleoside-diphosphatase activity;nucleoside-triphosphate diphosphatase activity","cytosol",{"$nulls":3},1,1,1,"7.3","7.3","7.3","18.609",0,"33.829",25195000,8,"0.414307","0.600696","-9.31581","-1.1024","sp|Q9NV35|NUD15_HUMAN","sp|Q9NV35|NUD15_HUMAN",2715,"Q9NV35","NUD15_HUMAN","Nucleotide triphosphate diphosphatase NUDT15 {ECO:0000305}",null,"NUDT15"]
[1,"16.4412","16.8042","19.3584",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;cellular protein modification process;exit from mitosis;free ubiquitin chain polymerization;positive regulation of ubiquitin protein ligase activity;protein K11-linked ubiquitination;protein K27-linked ubiquitination;protein K29-linked ubiquitination;protein K63-linked ubiquitination;protein K6-linked ubiquitination;protein ubiquitination","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","anaphase-promoting complex;cytoplasm;cytosol;nucleoplasm","Ubiquitin mediated proteolysis",null,null,2,2,2,"19.4","19.4","19.4","23.845",0,"9.8912",61295000,3,"0.450749","0.551812","-9.36074","-1.19618","sp|Q16763|UBE2S_HUMAN;tr|K7EPJ1|K7EPJ1_HUMAN","sp|Q16763|UBE2S_HUMAN;tr|K7EPJ1|K7EPJ1_HUMAN",1754,"Q16763","UBE2S_HUMAN","Ubiquitin-conjugating enzyme E2 S",null,"UBE2S"]
[1,"17.9566","19.5978","18.1046",{"$nulls":3},"tetrapyrrole biosynthetic process","hydroxymethylbilane synthase activity",{"$nulls":4},2,2,2,"11.2","11.2","11.2","20.892","0.0007619","2.9296",44700000,2,"0.413858","0.600406","-9.37291","-1.10125","tr|F5GY90|F5GY90_HUMAN;tr|F5H226|F5H226_HUMAN;tr|F5H345|F5H345_HUMAN;sp|P08397|HEM3_HUMAN","tr|F5GY90|F5GY90_HUMAN;tr|F5H226|F5H226_HUMAN;tr|F5H345|F5H345_HUMAN;sp|P08397|HEM3_HUMAN",562,"F5GY90","F5GY90_HUMAN",null,null,"HMBS"]
[1,"17.484","18.7563","18.6561",{"$nulls":9},1,1,1,"5.9","5.9","5.9","25.966","0.0014015","2.2576",35128000,1,"0.43219","0.579171","-9.46418","-1.14827","tr|A0A087WTU3|A0A087WTU3_HUMAN;sp|Q9Y6I9|TX264_HUMAN","tr|A0A087WTU3|A0A087WTU3_HUMAN;sp|Q9Y6I9|TX264_HUMAN",3052,"A0A087WTU3","A0A087WTU3_HUMAN",null,null,"TEX264"]
["18.6737",1,"19.7982","18.9499",{"$nulls":9},2,2,2,"18.4","18.4","18.4","19.914",0,"9.4358",50222000,5,"0.404757","0.615303","-9.53726","-1.07802","tr|H7C5S6|H7C5S6_HUMAN;sp|Q9UFC0|LRWD1_HUMAN","tr|H7C5S6|H7C5S6_HUMAN;sp|Q9UFC0|LRWD1_HUMAN",2820,"H7C5S6","H7C5S6_HUMAN",null,null,"LRWD1"]
[1,"19.4492","19.8741","20.0787",{"$nulls":4},"GTP binding;GTPase activity",{"$nulls":4},1,1,1,"4.9","4.9","4.9","21.214",0,"3.7063",50574000,5,"0.396538","0.623355","-9.75184","-1.05709","tr|F5H157|F5H157_HUMAN;sp|Q15286|RAB35_HUMAN","tr|F5H157|F5H157_HUMAN;sp|Q15286|RAB35_HUMAN",1688,"F5H157","F5H157_HUMAN",null,null,"RAB35"]
["20.0114",1,"19.4354","21.0937",{"$nulls":4},"carbohydrate binding",{"$nulls":4},1,1,1,"4.3","4.3","4.3","24.086","0.0037645","2.0537",56091000,3,"0.383008","0.637097","-9.75888","-1.02275","tr|G3V3R6|G3V3R6_HUMAN;sp|P17931|LEG3_HUMAN","tr|G3V3R6|G3V3R6_HUMAN;sp|P17931|LEG3_HUMAN",714,"G3V3R6","G3V3R6_HUMAN","Galectin {ECO:0000256|RuleBase:RU102079}",null,"LGALS3"]
[1,"20.1219","20.6996","20.0096",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,11,11,11,"9.6352","0.0075558","1.7509",26073000,4,"0.383373","0.636089","-9.79366","-1.02368","tr|K7EIN4|K7EIN4_HUMAN;tr|K7EQ63|K7EQ63_HUMAN;sp|Q13445|TMED1_HUMAN","tr|K7EIN4|K7EIN4_HUMAN;tr|K7EQ63|K7EQ63_HUMAN;sp|Q13445|TMED1_HUMAN",1558,"K7EIN4","K7EIN4_HUMAN",null,null,"TMED1"]
[1,"19.2804","20.6613","19.5026",{"$nulls":3},"signal transduction",{"$nulls":5},4,1,1,"39.3","13.1","13.1","12.198",0,"17.53",31523000,1,"0.407694","0.610471","-9.94171","-1.08551","tr|B1AKQ8|B1AKQ8_HUMAN;tr|F6X3N5|F6X3N5_HUMAN;tr|F6UT28|F6UT28_HUMAN;sp|P62873|GBB1_HUMAN;tr|F5H8J8|F5H8J8_HUMAN;tr|F5H100|F5H100_HUMAN;tr|F5H0S8|F5H0S8_HUMAN;tr|E9PCP0|E9PCP0_HUMAN;sp|P16520|GBB3_HUMAN","tr|B1AKQ8|B1AKQ8_HUMAN;tr|F6X3N5|F6X3N5_HUMAN;tr|F6UT28|F6UT28_HUMAN;sp|P62873|GBB1_HUMAN;tr|F5H8J8|F5H8J8_HUMAN;tr|F5H100|F5H100_HUMAN;tr|F5H0S8|F5H0S8_HUMAN;tr|E9PCP0|E9PCP0_HUMAN;sp|P16520|GBB3_HUMAN",1325,"B1AKQ8","B1AKQ8_HUMAN",null,null,"GNB1"]
["21.0109",1,"21.2896","20.6812",{"$nulls":3},"microtubule-based process","GTP binding;GTPase activity;structural constituent of cytoskeleton","cytoplasm;extracellular exosome;extracellular vesicle;microtubule;microtubule cytoskeleton;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,21,1,1,"65.2","2.7","2.7","49.906",0,"3.6941",475780000,7,"0.372831","0.651475","-9.97997","-0.996995","sp|Q13885|TBB2A_HUMAN","sp|Q13885|TBB2A_HUMAN",1590,"Q13885","TBB2A_HUMAN","Tubulin beta-2A chain",null,"TUBB2A"]
["20.4237",1,"20.7456","20.8351",{"$nulls":9},2,2,2,"36.4","36.4","36.4","7.8818",0,"3.8905",59415000,6,"0.388921","0.634838","-10.0785","-1.03775","tr|C9JB42|C9JB42_HUMAN;tr|C9JDR7|C9JDR7_HUMAN;tr|C9JDX6|C9JDX6_HUMAN;tr|F8WCZ4|F8WCZ4_HUMAN;tr|C9J2P2|C9J2P2_HUMAN;tr|E9PH18|E9PH18_HUMAN;tr|C9J2C4|C9J2C4_HUMAN;sp|O75190|DNJB6_HUMAN;tr|A0A0J9YX62|A0A0J9YX62_HUMAN;tr|C9JN01|C9JN01_HUMAN;sp|Q8WWF6|DNJB3_HUMAN","tr|C9JB42|C9JB42_HUMAN;tr|C9JDR7|C9JDR7_HUMAN;tr|C9JDX6|C9JDX6_HUMAN;tr|F8WCZ4|F8WCZ4_HUMAN;tr|C9J2P2|C9J2P2_HUMAN;tr|E9PH18|E9PH18_HUMAN;tr|C9J2C4|C9J2C4_HUMAN;sp|O75190|DNJB6_HUMAN;tr|A0A0J9YX62|A0A0J9YX62_HUMAN;tr|C9JN01|C9JN01_HUMAN;sp|Q8WWF6|DNJB3_HUMAN",328,"C9JB42","C9JB42_HUMAN",null,null,"DNAJB6"]
["17.3727",1,"19.2297","19.3844",{"$nulls":3},"neuron projection development","calcium ion binding","extracellular exosome;mitochondrial inner membrane",{"$nulls":3},1,1,1,5,5,5,"26.927","0.00039032","3.1641",151800000,3,"0.466154","0.536601","-10.1207","-1.23623","sp|Q9BUP0|EFHD1_HUMAN","sp|Q9BUP0|EFHD1_HUMAN",2459,"Q9BUP0","EFHD1_HUMAN","EF-hand domain-containing protein D1",null,"EFHD1"]
[1,"16.1636","18.7947","18.6504",{"$nulls":3},"in utero embryonic development;negative regulation of gene expression;positive regulation of fibroblast proliferation;regulation of DNA damage checkpoint;regulation of G2/M transition of mitotic cell cycle;ribonucleotide metabolic process;RNA catabolic process","RNA-DNA hybrid ribonuclease activity","nucleus;ribonuclease H2 complex","DNA replication",null,null,2,2,2,"7.4","7.4","7.4","35.138",0,"3.4891",52160000,8,"0.504614","0.513831","-10.1408","-1.33745","sp|Q5TBB1|RNH2B_HUMAN;tr|A0A087WXR7|A0A087WXR7_HUMAN;tr|A0A087WZJ6|A0A087WZJ6_HUMAN","sp|Q5TBB1|RNH2B_HUMAN;tr|A0A087WXR7|A0A087WXR7_HUMAN;tr|A0A087WZJ6|A0A087WZJ6_HUMAN",1838,"Q5TBB1","RNH2B_HUMAN","Ribonuclease H2 subunit B","Nase H2 subunit B","RNASEH2B"]
[1,"19.114","20.2432","20.3607",{"$nulls":3},"dUTP metabolic process","dUTP diphosphatase activity",{"$nulls":4},3,1,1,"29.4","9.1","9.1","15.548",0,"11.81",72555000,10,"0.425523","0.587639","-10.2449","-1.13113","tr|H0YNJ9|H0YNJ9_HUMAN;tr|H0YMM5|H0YMM5_HUMAN","tr|H0YNJ9|H0YNJ9_HUMAN;tr|H0YMM5|H0YMM5_HUMAN",3102,"H0YNJ9","H0YNJ9_HUMAN",null,null,"DUT"]
["12.7693",1,"18.2031","16.676",{"$nulls":3},"sphingolipid metabolic process","glucosylceramidase activity",{"$nulls":4},2,2,2,"5.3","5.3","5.3","50.263","0.0010653","2.3622",47448000,4,"0.663032","0.389371","-10.5549","-1.77872","tr|A0A0G2JNZ5|A0A0G2JNZ5_HUMAN;tr|A0A0G2JLB3|A0A0G2JLB3_HUMAN;sp|P04062|GLCM_HUMAN;tr|A0A0G2JNZ0|A0A0G2JNZ0_HUMAN","tr|A0A0G2JNZ5|A0A0G2JNZ5_HUMAN;tr|A0A0G2JLB3|A0A0G2JLB3_HUMAN;sp|P04062|GLCM_HUMAN;tr|A0A0G2JNZ0|A0A0G2JNZ0_HUMAN",488,"A0A0G2JNZ5","A0A0G2JNZ5_HUMAN","Glucosylceramidase {ECO:0000256|RuleBase:RU361188}",null,"GBA"]
["12.9485",1,"16.8322","18.2641",{"$nulls":3},"negative regulation of ATP citrate synthase activity;negative regulation of lyase activity;negative regulation of T cell receptor signaling pathway;peptidyl-histidine dephosphorylation;positive regulation of cell motility;positive regulation of insulin secretion involved in cellular response to glucose stimulus;protein dephosphorylation;regulation of actin cytoskeleton reorganization","calcium channel inhibitor activity;ion channel binding;protein histidine phosphatase activity","cytosol;extracellular exosome",{"$nulls":3},1,1,1,16,16,16,"13.832",0,"10.973",8554200,2,"0.655725","0.39126","-10.5739","-1.75733","sp|Q9NRX4|PHP14_HUMAN","sp|Q9NRX4|PHP14_HUMAN",2687,"Q9NRX4","PHP14_HUMAN","14 kDa phosphohistidine phosphatase {ECO:0000303|PubMed:12383260}",null,"PHPT1"]
["14.4929",1,"18.118","18.7132",{"$nulls":3},"aging;cartilage development;circadian rhythm;developmental growth;DNA biosynthetic process;dTMP biosynthetic process;dTTP biosynthetic process;dUMP metabolic process;immortalization of host cell by virus;intestinal epithelial cell maturation;liver regeneration;negative regulation of translation;nucleobase-containing small molecule interconversion;regulation of transcription involved in G1/S transition of mitotic cell cycle;response to cytokine;response to drug;response to ethanol;response to folic acid;response to glucocorticoid;response to organophosphorus;response to progesterone;response to toxic substance;response to vitamin A;tetrahydrofolate interconversion;uracil metabolic process","cofactor binding;drug binding;folic acid binding;nucleotide binding;protein homodimerization activity;sequence-specific mRNA binding;thymidylate synthase activity;translation repressor activity, nucleic acid binding","cytoplasm;cytosol;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;nucleolus;nucleus","Antifolate resistance;Metabolic pathways;One carbon pool by folate;Pyrimidine metabolism",null,null,4,4,4,"16.9","16.9","16.9","35.716",0,"6.8028",107130000,13,"0.593631","0.443083","-10.6692","-1.57992","sp|P04818|TYSY_HUMAN","sp|P04818|TYSY_HUMAN",502,"P04818","TYSY_HUMAN","Thymidylate synthase","S;Sase","TYMS"]
[1,"22.0232","22.5639","22.026",{"$nulls":4},"ATP binding",{"$nulls":4},1,1,1,"9.4","9.4","9.4","13.999","0.00040241","3.4063",335300000,10,"0.384099","0.635807","-10.7833","-1.02552","tr|K7EM02|K7EM02_HUMAN;tr|K7EIJ8|K7EIJ8_HUMAN;sp|Q8IYT4|KATL2_HUMAN","tr|K7EM02|K7EM02_HUMAN;tr|K7EIJ8|K7EIJ8_HUMAN;sp|Q8IYT4|KATL2_HUMAN",2027,"K7EM02","K7EM02_HUMAN",null,null,"KATNAL2"]
[1,"22.0502","22.3905","22.2723",{"$nulls":3},"aerobic respiration;mitochondrial respiratory chain complex IV assembly",null,"integral component of membrane;mitochondrial membrane;mitochondrion","Thermogenesis",null,null,1,1,1,11,11,11,"13.291","0.00039185","3.2005",118220000,2,"0.384567","0.636426","-10.8063","-1.0267","sp|Q5RI15|COX20_HUMAN","sp|Q5RI15|COX20_HUMAN",1821,"Q5RI15","COX20_HUMAN","Cytochrome c oxidase protein 20 homolog",null,"COX20"]
["16.2282",1,"19.9474","20.1586",{"$nulls":3},"cellular response to DNA damage stimulus;centrosome cycle;DNA replication;regulation of cell cycle;response to UV;translesion synthesis","chromatin binding","centrosome;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},2,2,2,"28.8","28.8","28.8","11.986",0,"43.737",64577000,11,"0.565599","0.469396","-11.4389","-1.50218","sp|Q15004|PAF15_HUMAN;tr|H0YMA4|H0YMA4_HUMAN;tr|H0YKX3|H0YKX3_HUMAN","sp|Q15004|PAF15_HUMAN;tr|H0YMA4|H0YMA4_HUMAN;tr|H0YKX3|H0YKX3_HUMAN",1656,"Q15004","PAF15_HUMAN","PCNA-associated factor {ECO:0000305}",null,"PCLAF"]
[1,"19.7522","22.1738","21.7834",{"$nulls":9},1,1,1,10,10,10,"11.181",0,"14.124",119180000,10,"0.46652","0.536596","-11.6025","-1.23719","tr|I3L4C5|I3L4C5_HUMAN;sp|Q9H832|UBE2Z_HUMAN","tr|I3L4C5|I3L4C5_HUMAN;sp|Q9H832|UBE2Z_HUMAN",2614,"I3L4C5","I3L4C5_HUMAN",null,null,"UBE2Z"]
[1,1,"14.1396","13.3051",{"$nulls":3},"cell proliferation;mitotic chromosome movement towards spindle pole;positive regulation of mitotic metaphase/anaphase transition;protein complex assembly;signaling","phosphoprotein phosphatase activity","cytosol;microtubule organizing center;mitochondrion;nucleus;spindle pole centrosome",{"$nulls":3},2,2,2,"3.7","3.7","3.7","95.114",0,"3.9374",11649000,3,"2.96897","0.505412","-12.7223","-30.4885","sp|Q15398|DLGP5_HUMAN","sp|Q15398|DLGP5_HUMAN",1699,"Q15398","DLGP5_HUMAN","Disks large-associated protein 5","AP-5","DLGAP5"]
[1,1,"15.4377","13.0535",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"1.3","1.3","1.3",240,"0.00040323","3.4267",8789800,2,"2.09676","0.406","-13.2456","-11.1112","tr|F8W6X9|F8W6X9_HUMAN;tr|A0A087WTQ6|A0A087WTQ6_HUMAN;sp|Q7Z5N4|SDK1_HUMAN","tr|F8W6X9|F8W6X9_HUMAN;tr|A0A087WTQ6|A0A087WTQ6_HUMAN;sp|Q7Z5N4|SDK1_HUMAN",1961,"F8W6X9","F8W6X9_HUMAN",null,null,"SDK1"]
[1,1,"14.1156","14.7505",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;apoptotic process;cell division;cell proliferation;meiotic sister chromatid cohesion, centromeric;metaphase/anaphase transition of mitotic cell cycle;mitotic cell cycle;mitotic cell cycle checkpoint;mitotic spindle assembly checkpoint;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein localization to kinetochore;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;sister chromatid cohesion","ATP binding;protein kinase activity;protein serine/threonine kinase activity","anaphase-promoting complex;condensed chromosome kinetochore;condensed chromosome outer kinetochore;condensed nuclear chromosome kinetochore;cytoplasm;cytosol;kinetochore;microtubule organizing center;perinuclear region of cytoplasm;spindle midzone","Cell cycle;Human T-cell leukemia virus 1 infection",null,null,1,1,1,"1.1","1.1","1.1","119.54","0.004717","1.9282",9576000,1,"3.25338","0.429091","-13.4331","-42.3165","sp|O60566|BUB1B_HUMAN","sp|O60566|BUB1B_HUMAN",294,"O60566","BUB1B_HUMAN","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta",null,"BUB1B"]
[1,1,"14.4628","14.5864",{"$nulls":3},"DNA methylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;regulation of RNA polymerase II transcriptional preinitiation complex assembly;transcription, DNA-templated;viral process","ATPase activity;transcription corepressor activity","cytosol;nuclear body;nucleoplasm;nucleus;transcription factor complex",{"$nulls":3},1,1,1,"1.1","1.1","1.1","136.39","0.0020942","2.2288",4763400,1,"4.6802","0.524444","-13.5246","-218.822","sp|Q6VMQ6|MCAF1_HUMAN","sp|Q6VMQ6|MCAF1_HUMAN",1907,"Q6VMQ6","MCAF1_HUMAN","Activating transcription factor 7-interacting protein 1",null,"ATF7IP"]
[1,1,"15.2691","14.4331",{"$nulls":3},"cell differentiation;cell migration;innate immune response;interferon-gamma-mediated signaling pathway;interleukin-12-mediated signaling pathway;interleukin-15-mediated signaling pathway;interleukin-2-mediated signaling pathway;interleukin-7-mediated signaling pathway;interleukin-9-mediated signaling pathway;intracellular signal transduction;MAPK cascade;peptidyl-tyrosine autophosphorylation;positive regulation of sprouting angiogenesis;protein phosphorylation;regulation of cell proliferation;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway;response to antibiotic;transmembrane receptor protein tyrosine kinase signaling pathway;type I interferon signaling pathway","ATP binding;CCR5 chemokine receptor binding;growth hormone receptor binding;metal ion binding;non-membrane spanning protein tyrosine kinase activity;protein phosphatase binding;protein tyrosine kinase activity;Ras guanyl-nucleotide exchange factor activity;receptor binding;ubiquitin protein ligase binding","cytoplasm;cytoskeleton;cytosol;endosome;extrinsic component of cytoplasmic side of plasma membrane;focal adhesion;nucleus","EGFR tyrosine kinase inhibitor resistance;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Signaling pathways regulating pluripotency of stem cells;Th1 and Th2 cell differentiation;Th17 cell differentiation;Toxoplasmosis;Tuberculosis;Viral carcinogenesis",null,null,1,1,1,"1.3","1.3","1.3","133.28","0.0072751","1.7907",17349000,2,"3.04129","0.490553","-13.8511","-33.1396","sp|P23458|JAK1_HUMAN","sp|P23458|JAK1_HUMAN",780,"P23458","JAK1_HUMAN","Tyrosine-protein kinase JAK1",null,"JAK1"]
[1,1,"14.8393","15.184",{"$nulls":3},"cell division;microtubule bundle formation;mitotic metaphase plate congression;negative regulation of cell growth;positive regulation of cyclin-dependent protein serine/threonine kinase activity;positive regulation of microtubule polymerization;positive regulation of transcription, DNA-templated;regulation of mitotic spindle organization","microtubule binding","cytoplasm;cytosol;microtubule cytoskeleton;midbody;nucleoplasm;spindle;spindle pole",{"$nulls":3},1,1,1,"3.9","3.9","3.9","38.796","0.0014011","2.2548",5772700,2,"3.8203","0.355333","-14.0116","-81.3019","sp|Q6PGN9|PSRC1_HUMAN","sp|Q6PGN9|PSRC1_HUMAN",1892,"Q6PGN9","PSRC1_HUMAN","Proline/serine-rich coiled-coil protein 1",null,"PSRC1"]
[1,1,"15.0398","15.4844",{"$nulls":3},"autophagy of peroxisome","fatty-acyl-CoA binding;lipid binding","integral component of membrane;nucleoplasm;nucleus;peroxisome",{"$nulls":3},1,1,1,"3.6","3.6","3.6","58.792","0.007292","1.8131",3467300,2,"3.61463","0.431143","-14.2621","-64.1559","tr|B7Z2R7|B7Z2R7_HUMAN","tr|B7Z2R7|B7Z2R7_HUMAN",3071,"B7Z2R7","B7Z2R7_HUMAN","Acyl-CoA-binding domain-containing protein 5 {ECO:0000256|PIRNR:PIRNR002412}",null,"ACBD5"]
[1,1,"15.7033","15.4928",{"$nulls":3},"intracellular signal transduction;negative regulation of protein tyrosine kinase activity;signal transduction","protein kinase inhibitor activity;SH3 domain binding","cytoplasm;mitochondrion",{"$nulls":3},1,1,1,"3.3","3.3","3.3","50.424","0.0010676","2.3794",8269100,2,"4.28411","0.309647","-14.5981","-138.688","sp|O60239|3BP5_HUMAN","sp|O60239|3BP5_HUMAN",281,"O60239","3BP5_HUMAN","SH3 domain-binding protein 5","H3BP-5","SH3BP5"]
[1,1,"15.9745","15.387",{"$nulls":3},"microtubule cytoskeleton organization","structural molecule activity","cytosol;microtubule cytoskeleton;spindle",{"$nulls":3},2,2,2,"4.9","4.9","4.9","92.819",0,"4.6864",15671000,6,"3.39792","0.40973","-14.6808","-49.984","sp|Q3KQU3|MA7D1_HUMAN;tr|E9PLH3|E9PLH3_HUMAN;tr|C9JIR3|C9JIR3_HUMAN;tr|H0YF21|H0YF21_HUMAN","sp|Q3KQU3|MA7D1_HUMAN;tr|E9PLH3|E9PLH3_HUMAN;tr|C9JIR3|C9JIR3_HUMAN;tr|H0YF21|H0YF21_HUMAN",1779,"Q3KQU3","MA7D1_HUMAN","MAP7 domain-containing protein 1",null,"MAP7D1"]
[1,1,"16.0836","16.0069",{"$nulls":3},"cell division;regulation of attachment of spindle microtubules to kinetochore",{"$nulls":5},1,1,1,5,5,5,"27.165","0.00039714","3.3187",10831000,1,"5.18695","0.408","-15.0453","-392.167","tr|J3KTQ0|J3KTQ0_HUMAN;sp|Q96R06|SPAG5_HUMAN","tr|J3KTQ0|J3KTQ0_HUMAN;sp|Q96R06|SPAG5_HUMAN",2341,"J3KTQ0","J3KTQ0_HUMAN",null,null,"SPAG5"]
[1,1,"17.2332","15.4632",{"$nulls":9},1,1,1,"2.2","2.2","2.2","51.911","0.0047668","2.0085",6213300,4,"2.48038","0.508343","-15.3482","-17.3424","tr|X6R9L0|X6R9L0_HUMAN;sp|Q13217|DNJC3_HUMAN","tr|X6R9L0|X6R9L0_HUMAN;sp|Q13217|DNJC3_HUMAN",1534,"X6R9L0","X6R9L0_HUMAN",null,null,"DNAJC3"]
[1,1,"16.6799","16.6671",{"$nulls":3},"phosphorelay signal transduction system","signal transducer activity","intracellular",{"$nulls":3},1,1,1,"5.1","5.1","5.1","23.693",0,"12.776",11941000,4,"6.77563",1,"-15.6735","-2442.39","tr|C9JSE3|C9JSE3_HUMAN;sp|O15287|FANCG_HUMAN","tr|C9JSE3|C9JSE3_HUMAN;sp|O15287|FANCG_HUMAN",210,"C9JSE3","C9JSE3_HUMAN",null,null,"FANCG"]
[1,1,"16.9519","16.5176",{"$nulls":3},"Cajal body organization",{"$nulls":5},1,1,1,"5.8","5.8","5.8","30.813","0.0010913","2.5404",7230500,3,"3.72033","0.422462","-15.7347","-72.4611","tr|G3V179|G3V179_HUMAN;tr|E9PMJ2|E9PMJ2_HUMAN;tr|J3KP39|J3KP39_HUMAN;sp|Q9BPY3|F118B_HUMAN","tr|G3V179|G3V179_HUMAN;tr|E9PMJ2|E9PMJ2_HUMAN;tr|J3KP39|J3KP39_HUMAN;sp|Q9BPY3|F118B_HUMAN",2409,"G3V179","G3V179_HUMAN",null,null,"FAM118B"]
[1,1,"16.0577","17.8095",{"$nulls":3},"branching morphogenesis of an epithelial tube;cell cycle phase transition;cell division;cellular response to bleomycin;cellular response to cisplatin;cellular response to DNA damage stimulus;cellular response to hydroxyurea;circadian rhythm;detection of abiotic stimulus;DNA replication;lung development;morphogenesis of an epithelium;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of double-strand break repair;regulation of circadian rhythm;response to abiotic stimulus;transcription, DNA-templated","protein heterodimerization activity;protein homodimerization activity","nuclear chromatin;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"1.1","1.1","1.1","138.66",0,"16.035",77828000,7,"2.52169","0.522985","-15.9336","-18.1914","sp|Q9UNS1|TIM_HUMAN","sp|Q9UNS1|TIM_HUMAN",2916,"Q9UNS1","TIM_HUMAN","Protein timeless homolog","TIM","TIMELESS"]
[1,1,"17.3848","16.8044",{"$nulls":4},"calcium ion binding",{"$nulls":4},1,1,1,"5.3","5.3","5.3","28.001","0.002095","2.2299",9455600,2,"3.48809","0.391543","-16.0946","-55.4546","tr|H0Y3T6|H0Y3T6_HUMAN;tr|G3V1E2|G3V1E2_HUMAN;sp|Q9BRK5|CAB45_HUMAN","tr|H0Y3T6|H0Y3T6_HUMAN;tr|G3V1E2|G3V1E2_HUMAN;sp|Q9BRK5|CAB45_HUMAN",2427,"H0Y3T6","H0Y3T6_HUMAN",null,null,"SDF4"]
[1,1,"16.8869","17.5382",{"$nulls":3},"cysteine biosynthetic process from serine",{"$nulls":5},1,1,1,"9.6","9.6","9.6","19.087",0,"3.7301",18501000,2,"3.39445","0.413263","-16.2126","-49.7846","tr|C9JMA6|C9JMA6_HUMAN;sp|P35520|CBS_HUMAN","tr|C9JMA6|C9JMA6_HUMAN;sp|P35520|CBS_HUMAN",931,"C9JMA6","C9JMA6_HUMAN",null,null,"CBS"]
[1,1,"17.2007","17.6566",{"$nulls":3},"cell proliferation;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;gene silencing by RNA;nuclear-transcribed mRNA poly(A) tail shortening;regulation of transcription, DNA-templated;regulation of translation;transcription, DNA-templated",null,"CCR4-NOT complex;cytosol;nucleus",{"$nulls":3},1,1,1,"2.4","2.4","2.4","55.215",0,"7.6588",28004000,9,"3.71583","0.406815","-16.4286","-72.086","sp|Q9UKZ1|CNO11_HUMAN","sp|Q9UKZ1|CNO11_HUMAN",2881,"Q9UKZ1","CNO11_HUMAN","CCR4-NOT transcription complex subunit 11",null,"CNOT11"]
[1,1,"18.2747","17.0006",{"$nulls":3},"intrinsic apoptotic signaling pathway in response to oxidative stress;positive regulation of apoptotic process;positive regulation of JNK cascade;positive regulation of kinase activity;positive regulation of MAPK cascade;ribosomal large subunit biogenesis","RNA binding;zinc ion binding","cytosol;cytosolic large ribosomal subunit;Golgi apparatus;nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},1,1,1,"3.1","3.1","3.1","54.271",0,"8.9247",18784000,1,"2.83481","0.536","-16.6377","-26.1172","sp|Q969S3|ZN622_HUMAN","sp|Q969S3|ZN622_HUMAN",2221,"Q969S3","ZN622_HUMAN","Zinc finger protein 622",null,"ZNF622"]
[1,1,"17.9601","17.3974",{"$nulls":3},"cilium assembly",null,"cilium",{"$nulls":3},1,1,1,"4.6","4.6","4.6","30.811",0,"3.5694",5131500,2,"3.54606","0.438667","-16.6787","-59.2839","sp|Q96LJ8|UBX10_HUMAN","sp|Q96LJ8|UBX10_HUMAN",2325,"Q96LJ8","UBX10_HUMAN","UBX domain-containing protein 10 {ECO:0000305}",null,"UBXN10"]
[1,1,"17.8423","17.5186",{"$nulls":3},"protein insertion into membrane",null,"integral component of membrane;mitochondrion",{"$nulls":3},1,1,1,"1.8","1.8","1.8","48.519","0.0078637","1.7343",15009000,3,"4.02627","0.352889","-16.6805","-103.063","tr|S4R3Q9|S4R3Q9_HUMAN;sp|Q15070|OXA1L_HUMAN;tr|J3KNA0|J3KNA0_HUMAN","tr|S4R3Q9|S4R3Q9_HUMAN;sp|Q15070|OXA1L_HUMAN;tr|J3KNA0|J3KNA0_HUMAN",1673,"S4R3Q9","S4R3Q9_HUMAN",null,null,"OXA1L"]
[1,1,"18.2455","17.1577",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"5.1","5.1","5.1","27.759","0.001114","2.7521",9282900,4,"2.97516","0.50464","-16.7016","-30.707","sp|Q9NW97|TMM51_HUMAN","sp|Q9NW97|TMM51_HUMAN",2726,"Q9NW97","TMM51_HUMAN","Transmembrane protein 51",null,"TMEM51"]
[1,1,"16.7122","19.0455",{"$nulls":3},"cell differentiation;covalent chromatin modification;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;multicellular organism development;regulation of transcription, DNA-templated;spermatogenesis;transcription, DNA-templated","histone binding","nuclear chromatin;nucleoplasm;protein complex",{"$nulls":3},2,2,2,"11.4","11.4","11.4","22.433",0,"3.5436",35696000,3,"2.32393","0.457268","-16.8788","-14.4683","sp|Q9NVP2|ASF1B_HUMAN;tr|K7ES22|K7ES22_HUMAN;tr|K7ELW9|K7ELW9_HUMAN;sp|Q9Y294|ASF1A_HUMAN","sp|Q9NVP2|ASF1B_HUMAN;tr|K7ES22|K7ES22_HUMAN;tr|K7ELW9|K7ELW9_HUMAN;sp|Q9Y294|ASF1A_HUMAN",2723,"Q9NVP2","ASF1B_HUMAN","Histone chaperone ASF1B",null,"ASF1B"]
[1,1,"20.0886","16.1209",{"$nulls":3},"cell cycle;cell division;DNA replication","DNA binding","nucleus",{"$nulls":3},2,2,2,"4.7","4.7","4.7","49.741","0.0010597","2.3301",35707000,2,"1.87986","0.390168","-17.1047","-8.62189","sp|Q6IQ49|SDE2_HUMAN","sp|Q6IQ49|SDE2_HUMAN",1871,"Q6IQ49","SDE2_HUMAN","Replication stress response regulator SDE2 {ECO:0000305}",null,"SDE2"]
[1,1,"18.4137","17.8677",{"$nulls":3},"apoptotic process;regulation of apoptotic process","cysteine-type endopeptidase activity",{"$nulls":4},1,1,1,"15.5","15.5","15.5","13.925",0,"6.0086",9150900,3,"3.59594","0.416276","-17.1407","-62.7892","tr|E7EQ01|E7EQ01_HUMAN;tr|E7EVN1|E7EVN1_HUMAN;tr|E7ETB7|E7ETB7_HUMAN;tr|E7EQ06|E7EQ06_HUMAN;tr|A0A0A0MS31|A0A0A0MS31_HUMAN;sp|Q14790|CASP8_HUMAN","tr|E7EQ01|E7EQ01_HUMAN;tr|E7EVN1|E7EVN1_HUMAN;tr|E7ETB7|E7ETB7_HUMAN;tr|E7EQ06|E7EQ06_HUMAN;tr|A0A0A0MS31|A0A0A0MS31_HUMAN;sp|Q14790|CASP8_HUMAN",1646,"E7EQ01","E7EQ01_HUMAN",null,null,"CASP8"]
[1,1,"18.0332","18.6309",{"$nulls":3},"cell cycle phase transition;cell division;DNA replication;DNA replication checkpoint;intra-S DNA damage checkpoint;positive regulation of cell proliferation;regulation of nuclear cell cycle DNA replication;replication fork arrest;replication fork protection;response to UV","DNA binding","cytoplasm;intracellular membrane-bounded organelle;nuclear chromatin;nucleoplasm;nucleus;replication fork protection complex",{"$nulls":3},1,1,1,"3.7","3.7","3.7","34.555",0,"9.2699",15669000,3,"3.52698","0.424516","-17.332","-57.9951","sp|Q9BVW5|TIPIN_HUMAN","sp|Q9BVW5|TIPIN_HUMAN",2475,"Q9BVW5","TIPIN_HUMAN","TIMELESS-interacting protein",null,"TIPIN"]
[1,1,"18.82","18.1612",{"$nulls":3},"abscission;cell separation after cytokinesis;endosomal transport;macroautophagy;mitotic cytokinesis checkpoint;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of cytokinesis;nucleus organization;positive regulation of viral release from host cell;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;regulation of viral process;ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;vacuolar transport;viral budding via host ESCRT complex;viral life cycle","protein homodimerization activity","cytosol;ESCRT III complex;extracellular exosome;Flemming body;late endosome membrane;midbody","Endocytosis;Necroptosis",null,null,1,1,1,6,6,6,"26.41","0.0003864","3.0672",23778000,1,"3.45048","0.421111","-17.4906","-53.1034","sp|Q96CF2|CHM4C_HUMAN","sp|Q96CF2|CHM4C_HUMAN",2246,"Q96CF2","CHM4C_HUMAN","Charged multivesicular body protein 4c",null,"CHMP4C"]
[1,1,"18.7359","18.5816",{"$nulls":3},"tRNA methylation","tRNA (cytosine) methyltransferase activity",{"$nulls":4},1,1,1,"3.4","3.4","3.4","43.426",0,"8.14",57316000,3,"4.7193","0.476","-17.6587","-228.898","sp|Q6P1Q9|MET2B_HUMAN","sp|Q6P1Q9|MET2B_HUMAN",1884,"Q6P1Q9","MET2B_HUMAN","Methyltransferase-like protein 2B",null,"METTL2B"]
[1,1,"19.5862","19.6095",{"$nulls":9},1,1,1,"12.6","12.6","12.6","9.5794","0.00038971","3.1361",7935100,5,"6.40798","0.544","-18.5979","-1599.51","tr|F8WDN6|F8WDN6_HUMAN;sp|Q9BXI6|TB10A_HUMAN","tr|F8WDN6|F8WDN6_HUMAN;sp|Q9BXI6|TB10A_HUMAN",2495,"F8WDN6","F8WDN6_HUMAN",null,null,"TBC1D10A"]
[1,1,"20.0413","19.2753",{"$nulls":3},"box C/D snoRNP assembly;maturation of LSU-rRNA;maturation of SSU-rRNA;mRNA splicing, via spliceosome;rRNA processing;single fertilization","ATPase binding;box C/D snoRNA binding;RNA binding;U3 snoRNA binding;U4 snRNA binding;U4atac snRNA binding","box C/D snoRNP complex;dense fibrillar component;nucleolus;nucleoplasm;nucleus;precatalytic spliceosome;protein complex;small-subunit processome;U4/U6 x U5 tri-snRNP complex","Ribosome biogenesis in eukaryotes;Spliceosome",null,null,1,1,1,"9.4","9.4","9.4","14.173","0.00076658","2.9824",42225000,2,"3.37567","0.416615","-18.6583","-48.7189","sp|P55769|NH2L1_HUMAN;tr|B1AHD1|B1AHD1_HUMAN","sp|P55769|NH2L1_HUMAN;tr|B1AHD1|B1AHD1_HUMAN",1211,"P55769","NH2L1_HUMAN","NHP2-like protein 1",null,"SNU13"]
[1,1,"20.2796","19.414",{"$nulls":3},"ATP biosynthetic process;ATP synthesis coupled proton transport;cristae formation;mitochondrial ATP synthesis coupled proton transport;oxidative phosphorylation;response to copper ion","ATPase activity;proton-transporting ATP synthase activity, rotational mechanism;transmembrane transporter activity;transporter activity","mitochondrial inner membrane;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,1,1,1,"8.3","8.3","8.3","17.49",0,"16.908",23208000,6,"3.2783","0.426419","-18.8468","-43.5488","sp|P30049|ATPD_HUMAN","sp|P30049|ATPD_HUMAN",860,"P30049","ATPD_HUMAN","ATP synthase subunit delta, mitochondrial",null,"ATP5D"]
[1,1,"20.0382","20.5161",{"$nulls":9},1,1,1,"13.6","13.6","13.6","8.6344",0,"17.257",30223000,9,"3.81363","0.34112","-19.2771","-80.6801","tr|H0YJ87|H0YJ87_HUMAN;tr|A0A087WTC9|A0A087WTC9_HUMAN;tr|G3V5I6|G3V5I6_HUMAN;tr|G3V256|G3V256_HUMAN;tr|H0YJA2|H0YJA2_HUMAN;sp|Q6PJT7|ZC3HE_HUMAN","tr|H0YJ87|H0YJ87_HUMAN;tr|A0A087WTC9|A0A087WTC9_HUMAN;tr|G3V5I6|G3V5I6_HUMAN;tr|G3V256|G3V256_HUMAN;tr|H0YJA2|H0YJA2_HUMAN;sp|Q6PJT7|ZC3HE_HUMAN",1896,"H0YJ87","H0YJ87_HUMAN",null,null,"ZC3H14"]
[1,1,"20.1686","21.0501",{"$nulls":9},1,1,1,"13.4","13.4","13.4","10.865",0,"25.762",47454000,7,"3.29695","0.425714","-19.6094","-44.495","tr|C9J7Y4|C9J7Y4_HUMAN;sp|Q8WWK9|CKAP2_HUMAN","tr|C9J7Y4|C9J7Y4_HUMAN;sp|Q8WWK9|CKAP2_HUMAN",2151,"C9J7Y4","C9J7Y4_HUMAN",null,null,"CKAP2"]
[1,1,"21.8406","21.6751",{"$nulls":4},"cysteine-type endopeptidase activity",{"$nulls":4},1,1,1,"9.4","9.4","9.4","13.366","0.0010661","2.3725",141150000,4,"4.79869","0.466286","-20.7578","-250.806","tr|C9JXR7|C9JXR7_HUMAN;tr|A0A087WU32|A0A087WU32_HUMAN;tr|A8MVM1|A8MVM1_HUMAN;sp|P42574|CASP3_HUMAN","tr|C9JXR7|C9JXR7_HUMAN;tr|A0A087WU32|A0A087WU32_HUMAN;tr|A8MVM1|A8MVM1_HUMAN;sp|P42574|CASP3_HUMAN",995,"C9JXR7","C9JXR7_HUMAN",null,null,"CASP3"]

{"sheet":"SW480_Signproteins_3DsiKvssiC","index":3,"n_rows":153,"n_cols":36,"rows_kept":153}
["3D siKRAS 1 ","3D siKRAS 2","3D NT 1 ","3D NT 2 ","C: Only identified by site","C: Reverse","C: Potential contaminant","C: GOBP name","C: GOMF name","C: GOCC name","C: KEGG pathway name","C: Student's T-test Significant 3D siKRAS_3D NT","C: Student's T-test significant","N: Peptides","N: Razor + unique peptides","N: Unique peptides","N: Sequence coverage [%]","N: Unique + razor sequence coverage [%]","N: Unique sequence coverage [%]","N: Mol. weight [kDa]","N: Q-value","N: Score","N: Intensity","N: MS/MS Count","N: -Log Student's T-test p-value 3D siKRAS_3D NT","N: Student's T-test q-value 3D siKRAS_3D NT","N: Student's T-test Difference 3D siKRAS_3D NT","N: Student's T-test Test statistic 3D siKRAS_3D NT","T: Protein IDs","T: Majority protein IDs","T: id","T: Uniprot IDs","T: Uniprot name","T: Uniprot full protein name","T: Uniprot short protein name","T: Gene name"]
["22.0783","21.8296",1,1,{"$nulls":4},"transcription coactivator activity","nucleus",{"$nulls":3},1,1,1,30,30,30,"6.8585","0.00039494","3.2904",25687000,2,"4.45327","0.393333","20.954","168.509","tr|J3KTD8|J3KTD8_HUMAN","tr|J3KTD8|J3KTD8_HUMAN",3110,"J3KTD8","J3KTD8_HUMAN",null,null,"CBFB"]
["19.3371","19.7789",1,1,{"$nulls":9},1,1,1,"16.9","16.9","16.9","9.7027","0.0063249","1.8465",16566000,1,"3.8489","0.406095","18.558","84.0245","tr|F8WF15|F8WF15_HUMAN;tr|F8W8F0|F8W8F0_HUMAN;tr|C9J180|C9J180_HUMAN;sp|Q96LR5|UB2E2_HUMAN","tr|F8WF15|F8WF15_HUMAN;tr|F8W8F0|F8W8F0_HUMAN;tr|C9J180|C9J180_HUMAN;sp|Q96LR5|UB2E2_HUMAN",2326,"F8WF15","F8WF15_HUMAN",null,null,"UBE2E2"]
["19.6104","19.4939",1,1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"21.7","21.7","21.7","8.8131",0,"39.841",41441000,8,"5.00668","0.272","18.5521","318.667","tr|C9JAW5|C9JAW5_HUMAN;sp|Q9Y241|HIG1A_HUMAN;tr|C9JNU6|C9JNU6_HUMAN","tr|C9JAW5|C9JAW5_HUMAN;sp|Q9Y241|HIG1A_HUMAN;tr|C9JNU6|C9JNU6_HUMAN",2938,"C9JAW5","C9JAW5_HUMAN",null,null,"HIG1 domain-containing protein"]
["18.213","18.2832",1,1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,3,3,3,"38.309","0.0010784","2.4289",18691000,4,"5.38349","0.544","17.2481","491.747","tr|A0A0A0MT98|A0A0A0MT98_HUMAN;tr|A0A0G2JKZ1|A0A0G2JKZ1_HUMAN;sp|O15533|TPSN_HUMAN;tr|A2AB90|A2AB90_HUMAN;tr|A0A0G2JH37|A0A0G2JH37_HUMAN;tr|A0A0A0MSV9|A0A0A0MSV9_HUMAN","tr|A0A0A0MT98|A0A0A0MT98_HUMAN;tr|A0A0G2JKZ1|A0A0G2JKZ1_HUMAN;sp|O15533|TPSN_HUMAN;tr|A2AB90|A2AB90_HUMAN;tr|A0A0G2JH37|A0A0G2JH37_HUMAN;tr|A0A0A0MSV9|A0A0A0MSV9_HUMAN",226,"A0A0A0MT98","A0A0A0MT98_HUMAN",null,null,"TAPBP"]
["18.0497","17.7147",1,1,{"$nulls":9},1,1,1,"8.4","8.4","8.4","37.353",0,"3.5654",30041000,1,"4.00683","0.334316","16.8822","100.782","tr|F5GZY1|F5GZY1_HUMAN;sp|Q9H993|ARMT1_HUMAN","tr|F5GZY1|F5GZY1_HUMAN;sp|Q9H993|ARMT1_HUMAN",2619,"F5GZY1","F5GZY1_HUMAN",null,null,"ARMT1"]
["17.6584","18.0331",1,1,{"$nulls":5},"nucleolus",{"$nulls":3},1,1,1,3,3,3,"48.208",0,"3.7326",10452000,2,"3.90793","0.3448","16.8457","89.9341","tr|J3QSV6|J3QSV6_HUMAN;sp|O76021|RL1D1_HUMAN","tr|J3QSV6|J3QSV6_HUMAN;sp|O76021|RL1D1_HUMAN",384,"J3QSV6","J3QSV6_HUMAN",null,null,"RSL1D1"]
["17.924","17.5144",1,1,{"$nulls":9},1,1,1,24,24,24,"5.4142","0.0063207","1.8408",10260000,1,"3.82372","0.370783","16.7192","81.6225","tr|D6R907|D6R907_HUMAN;tr|D6RBI9|D6RBI9_HUMAN;tr|D6RBR6|D6RBR6_HUMAN;tr|D6RFG3|D6RFG3_HUMAN;tr|D6REL6|D6REL6_HUMAN;tr|I6L9I8|I6L9I8_HUMAN;sp|Q9Y6I3|EPN1_HUMAN;sp|Q9H201|EPN3_HUMAN","tr|D6R907|D6R907_HUMAN;tr|D6RBI9|D6RBI9_HUMAN;tr|D6RBR6|D6RBR6_HUMAN;tr|D6RFG3|D6RFG3_HUMAN;tr|D6REL6|D6REL6_HUMAN;tr|I6L9I8|I6L9I8_HUMAN;sp|Q9Y6I3|EPN1_HUMAN;sp|Q9H201|EPN3_HUMAN",2571,"D6R907","D6R907_HUMAN",null,null,"EPN3"]
["17.4439","16.8852",1,1,{"$nulls":3},"actin cytoskeleton organization;endocytosis",null,"intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},2,2,2,"7.8","7.8","7.8","49.712","0.0047749","2.0326",12021000,2,"3.52515","0.41125","16.1646","57.8729","tr|M0R0F9|M0R0F9_HUMAN;tr|W4VSQ9|W4VSQ9_HUMAN;sp|Q15642|CIP4_HUMAN;tr|M0R070|M0R070_HUMAN;tr|M0R2H7|M0R2H7_HUMAN","tr|M0R0F9|M0R0F9_HUMAN;tr|W4VSQ9|W4VSQ9_HUMAN;sp|Q15642|CIP4_HUMAN;tr|M0R070|M0R070_HUMAN;tr|M0R2H7|M0R2H7_HUMAN",1711,"M0R0F9","M0R0F9_HUMAN",null,null,"TRIP10"]
["17.113","16.9009",1,1,{"$nulls":3},"androgen receptor signaling pathway;circadian rhythm;intracellular steroid hormone receptor signaling pathway;mRNA processing;mRNA stabilization;nuclear-transcribed mRNA catabolic process;positive regulation of circadian rhythm;positive regulation of mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of alternative mRNA splicing, via spliceosome;RNA splicing;transcription initiation from RNA polymerase II promoter","ATP binding;core promoter sequence-specific DNA binding;ligand-dependent nuclear receptor transcription coactivator activity;phosphoprotein binding;receptor activity;RNA binding;RNA polymerase II transcription cofactor activity;thyroid hormone receptor binding;transcription coactivator activity;transcription cofactor activity;vitamin D receptor binding","extracellular exosome;mediator complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"4.3","4.3","4.3","108.66","0.0044384","2.0412",11093000,2,"4.35763","0.295","16.0069","150.938","sp|Q9Y2W1|TR150_HUMAN","sp|Q9Y2W1|TR150_HUMAN",2960,"Q9Y2W1","TR150_HUMAN","Thyroid hormone receptor-associated protein 3",null,"THRAP3"]
["16.7172","16.9115",1,1,{"$nulls":5},"cytosol;Golgi apparatus;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"2.8","2.8","2.8","60.741",0,"8.6202",10786000,3,"4.42338","0.337143","15.8143","162.808","sp|Q8IWE2|NXP20_HUMAN","sp|Q8IWE2|NXP20_HUMAN",2013,"Q8IWE2","NXP20_HUMAN","Protein NOXP20",null,"FAM114A1"]
["18.6178","14.7599",1,1,{"$nulls":3},"tRNA modification;wybutosine biosynthetic process","iron ion binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;protein homodimerization activity;tRNA binding;tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity","cytoplasm",{"$nulls":3},1,1,1,"2.5","2.5","2.5","36.547","0.0075758","1.7615",59591000,2,"1.83026","0.392292","15.6889","8.13345","sp|A2RUC4|TYW5_HUMAN","sp|A2RUC4|TYW5_HUMAN",98,"A2RUC4","TYW5_HUMAN","tRNA wybutosine-synthesizing protein 5","TYW5","TYW5"]
["16.7224","16.529",1,1,{"$nulls":3},"cell recognition;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;homophilic cell adhesion via plasma membrane adhesion molecules","cell adhesion molecule binding;protein homodimerization activity;receptor activity;receptor binding","cell-cell adherens junction;extracellular exosome;integral component of plasma membrane",{"$nulls":3},1,1,1,"4.6","4.6","4.6","42.785","0.0031013","2.1168",18897000,1,"4.41677","0.314667","15.6257","161.574","sp|Q8NFZ8|CADM4_HUMAN","sp|Q8NFZ8|CADM4_HUMAN",2100,"Q8NFZ8","CADM4_HUMAN","Cell adhesion molecule 4",null,"CADM4"]
["16.2521","16.3353",1,1,{"$nulls":3},"carbohydrate metabolic process;glucosamine catabolic process;N-acetylglucosamine metabolic process","glucosamine-6-phosphate deaminase activity","cytosol;nucleus","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,2,1,1,17,"10.9","10.9","31.084","0.004749","1.99",7979400,1,"5.13185","0.3264","15.2937","368.065","sp|Q8TDQ7|GNPI2_HUMAN","sp|Q8TDQ7|GNPI2_HUMAN",2121,"Q8TDQ7","GNPI2_HUMAN","Glucosamine-6-phosphate isomerase 2",null,"GNPDA2"]
["16.0467","16.2306",1,1,{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},1,1,1,2,2,2,"102.13","0.00039432","3.2748",11418000,1,"4.43308","0.363077","15.1387","164.638","tr|A0A087WWP4|A0A087WWP4_HUMAN;sp|Q96T37|RBM15_HUMAN","tr|A0A087WWP4|A0A087WWP4_HUMAN;sp|Q96T37|RBM15_HUMAN",2360,"A0A087WWP4","A0A087WWP4_HUMAN",null,null,"RBM15"]
["16.1281","15.976",1,1,{"$nulls":4},"methyltransferase activity","nucleolus",{"$nulls":3},1,1,1,"4.2","4.2","4.2","34.2","0.002772","2.1738",2449400,1,"4.59331","0.429091","15.0521","197.992","tr|E9PPY3|E9PPY3_HUMAN;sp|O43159|RRP8_HUMAN","tr|E9PPY3|E9PPY3_HUMAN;sp|O43159|RRP8_HUMAN",231,"E9PPY3","E9PPY3_HUMAN",null,null,"RRP8"]
["15.1243","15.6315",1,1,{"$nulls":9},1,1,1,"3.2","3.2","3.2","79.972",0,"4.1769",10687000,3,"3.50735","0.387059","14.3779","56.6989","tr|H0YAJ5|H0YAJ5_HUMAN;tr|G5E9Y1|G5E9Y1_HUMAN;sp|Q92870|APBB2_HUMAN","tr|H0YAJ5|H0YAJ5_HUMAN;tr|G5E9Y1|G5E9Y1_HUMAN;sp|Q92870|APBB2_HUMAN",2197,"H0YAJ5","H0YAJ5_HUMAN",null,null,"APBB2"]
["15.2169","14.7315",1,1,{"$nulls":9},1,1,1,"1.4","1.4","1.4","88.181","0.003096","2.0916",17737000,1,"3.52077","0.398788","13.9742","57.5822","tr|C9J8U1|C9J8U1_HUMAN;tr|F8WAN1|F8WAN1_HUMAN;sp|Q69YQ0|CYTSA_HUMAN","tr|C9J8U1|C9J8U1_HUMAN;tr|F8WAN1|F8WAN1_HUMAN;sp|Q69YQ0|CYTSA_HUMAN",1861,"C9J8U1","C9J8U1_HUMAN",null,null,"SPECC1L"]
["14.1172","14.4393",1,1,{"$nulls":3},"axon development;microtubule cytoskeleton organization;regulation of dendrite development;regulation of Golgi organization;regulation of microtubule polymerization;regulation of organelle organization","calmodulin binding;microtubule minus-end binding;spectrin binding","cytosol;Golgi apparatus;microtubule end",{"$nulls":3},1,1,1,"0.9","0.9","0.9","168.09",0,"28.136",3422800,9,"3.83253","0.387636","13.2783","82.4548","sp|Q08AD1|CAMP2_HUMAN","sp|Q08AD1|CAMP2_HUMAN",1478,"Q08AD1","CAMP2_HUMAN","Calmodulin-regulated spectrin-associated protein 2 {ECO:0000305}",null,"CAMSAP2"]
["13.7623","13.8873",1,1,{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell cycle;cell division;mitotic sister chromatid cohesion;mitotic spindle assembly;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of cell proliferation;positive regulation of synapse maturation;positive regulation of synaptic plasticity;positive regulation of ubiquitin protein ligase activity;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of dendrite development;regulation of meiotic nuclear division;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;sister chromatid cohesion","anaphase-promoting complex binding;enzyme binding;histone deacetylase binding;protein C-terminus binding;ubiquitin-protein transferase activator activity","centrosome;cytosol;nucleoplasm;perinuclear region of cytoplasm;protein complex;spindle;spindle pole","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Ubiquitin mediated proteolysis;Viral carcinogenesis",null,null,1,1,1,"2.2","2.2","2.2","54.722","0.0010646","2.3595",6752100,2,"4.6241","0.472","12.8248","205.136","sp|Q12834|CDC20_HUMAN","sp|Q12834|CDC20_HUMAN",1498,"Q12834","CDC20_HUMAN","Cell division cycle protein 20 homolog",null,"CDC20"]
["12.5208","13.0494",1,1,{"$nulls":5},"cytoplasm;microtubule",{"$nulls":3},2,2,2,"1.9","1.9","1.9","171.69",0,"6.3509",17586000,2,"3.29877","0.436098","11.7851","44.5886","sp|Q9Y4F5|C170B_HUMAN;tr|J3KQR7|J3KQR7_HUMAN","sp|Q9Y4F5|C170B_HUMAN;tr|J3KQR7|J3KQR7_HUMAN",2999,"Q9Y4F5","C170B_HUMAN","Centrosomal protein of 170 kDa protein B",null,"CEP170B"]
["19.5308","19.2286","14.1274","14.8652",{"$nulls":3},"cholesterol biosynthetic process;isoprenoid biosynthetic process;ketone body biosynthetic process;regulation of lipid metabolic process","hydroxymethylglutaryl-CoA synthase activity","mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Butanoate metabolism;Metabolic pathways;PPAR signaling pathway;Synthesis and degradation of ketone bodies;Terpenoid backbone biosynthesis;Valine, leucine and isoleucine degradation",null,null,3,3,3,"8.1","8.1","8.1","56.635",0,"10.023",69947000,5,"2.18061","0.4224","4.88336","12.2504","sp|P54868|HMCS2_HUMAN","sp|P54868|HMCS2_HUMAN",1198,"P54868","HMCS2_HUMAN","Hydroxymethylglutaryl-CoA synthase, mitochondrial","MG-CoA synthase","HMGCS2"]
["20.5294","20.4293","17.1926","17.3741",{"$nulls":3},"beta-catenin destruction complex assembly;beta-catenin destruction complex disassembly;cell cycle;cell division;cell morphogenesis;cell surface receptor signaling pathway;Golgi organization;intermediate filament cytoskeleton organization;negative regulation of canonical Wnt signaling pathway;peptidyl-serine phosphorylation;phagocytosis;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein phosphorylation;regulation of cell shape;regulation of GTP binding;signal transduction;Wnt signaling pathway","ATP binding;kinase activity;protein kinase activity;protein serine/threonine kinase activity","beta-catenin destruction complex;centrosome;ciliary basal body;cilium;condensed chromosome kinetochore;cytosol;intracellular ribonucleoprotein complex;membrane;nuclear speck","Breast cancer;Gastric cancer;Hedgehog signaling pathway;Hepatocellular carcinoma;Human papillomavirus infection;Wnt signaling pathway",null,null,2,2,2,"9.8","9.8","9.8","38.914",0,"23.34",146750000,10,"2.979","0.514939","3.19601","30.8432","sp|P48729|KC1A_HUMAN;tr|U3KQ83|U3KQ83_HUMAN;tr|U3KPX3|U3KPX3_HUMAN;tr|H0Y9X2|H0Y9X2_HUMAN;tr|U3KQK7|U3KQK7_HUMAN;tr|D6REM4|D6REM4_HUMAN;tr|E7ETM0|E7ETM0_HUMAN;sp|Q8N752|KC1AL_HUMAN","sp|P48729|KC1A_HUMAN;tr|U3KQ83|U3KQ83_HUMAN;tr|U3KPX3|U3KPX3_HUMAN;tr|H0Y9X2|H0Y9X2_HUMAN;tr|U3KQK7|U3KQK7_HUMAN;tr|D6REM4|D6REM4_HUMAN;tr|E7ETM0|E7ETM0_HUMAN;sp|Q8N752|KC1AL_HUMAN",1060,"P48729","KC1A_HUMAN","Casein kinase I isoform alpha","KI-alpha","CSNK1A1"]
["19.4558","19.4575","17.3621","16.5035",{"$nulls":3},"cell division;cell proliferation;DNA repair;mitotic sister chromatid cohesion;negative regulation of cell proliferation;regulation of cell proliferation;sister chromatid cohesion","ATP binding;DNA binding","chromatin;chromosome;chromosome, centromeric region;cytosol;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"5.6","5.6","5.6","164.67",0,"14.074",165070000,13,"1.55694","0.332226","2.5238","5.87874","sp|Q9NTI5|PDS5B_HUMAN;tr|A9IYQ1|A9IYQ1_HUMAN","sp|Q9NTI5|PDS5B_HUMAN",2697,"Q9NTI5","PDS5B_HUMAN","Sister chromatid cohesion protein PDS5 homolog B",null,"PDS5B"]
["25.6961","25.7212","23.801","23.526",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular protein metabolic process;CENP-A containing nucleosome assembly;chromatin silencing at rDNA;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;DNA-templated transcription, initiation;double-strand break repair via nonhomologous end joining;negative regulation of gene expression, epigenetic;negative regulation of megakaryocyte differentiation;nucleosome assembly;positive regulation of gene expression, epigenetic;protein heterotetramerization;regulation of gene silencing by miRNA;regulation of hematopoietic stem cell differentiation;regulation of megakaryocyte differentiation;telomere capping;telomere organization","DNA binding;histone binding;protein domain specific binding;protein heterodimerization activity;RNA binding","extracellular exosome;extracellular matrix;extracellular region;membrane;nuclear chromosome;nuclear chromosome, telomeric region;nuclear nucleosome;nucleoplasm;nucleosome;nucleus;protein complex","Alcoholism;Systemic lupus erythematosus;Viral carcinogenesis",null,null,5,5,5,"46.6","46.6","46.6","11.367",0,"12.459",987460000,14,"2.34407","0.462914","2.04515","14.81","sp|P62805|H4_HUMAN","sp|P62805|H4_HUMAN",1314,"P62805","H4_HUMAN","Histone H4",null,"HIST1H4A;HIST1H4B;HIST1H4C;HIST1H4D;HIST1H4E;HIST1H4F;HIST1H4H;HIST1H4I;HIST1H4J;HIST1H4K;HIST1H4L;HIST2H4A;HIST2H4B;HIST4H4"]
["25.2501","25.2097","23.4561","23.2808",{"$nulls":4},"DNA binding;protein heterodimerization activity","nucleosome;nucleus",{"$nulls":3},3,3,3,25,25,25,"10.334",0,"17.788",596510000,14,"2.63301","0.574933","1.86146","20.6894","tr|K7EMV3|K7EMV3_HUMAN;tr|B4DEB1|B4DEB1_HUMAN;tr|K7EK07|K7EK07_HUMAN;sp|Q71DI3|H32_HUMAN;sp|Q16695|H31T_HUMAN;sp|P84243|H33_HUMAN;sp|P68431|H31_HUMAN;tr|K7ES00|K7ES00_HUMAN;tr|K7EP01|K7EP01_HUMAN;sp|Q6NXT2|H3C_HUMAN;tr|Q5TEC6|Q5TEC6_HUMAN","tr|K7EMV3|K7EMV3_HUMAN;tr|B4DEB1|B4DEB1_HUMAN;tr|K7EK07|K7EK07_HUMAN;sp|Q71DI3|H32_HUMAN;sp|Q16695|H31T_HUMAN;sp|P84243|H33_HUMAN;sp|P68431|H31_HUMAN;tr|K7ES00|K7ES00_HUMAN;tr|K7EP01|K7EP01_HUMAN;sp|Q6NXT2|H3C_HUMAN;tr|Q5TEC6|Q5TEC6_HUMAN",1362,"K7EMV3","K7EMV3_HUMAN","Histone H3 {ECO:0000256|RuleBase:RU004471}",null,"H3F3B"]
["17.0651","16.6618","15.4152","14.673",{"$nulls":3},"chromatin silencing;covalent chromatin modification;dosage compensation;establishment of protein localization to chromatin;negative regulation of cell cycle G2/M phase transition;negative regulation of gene expression, epigenetic;negative regulation of histone H3-K27 methylation;negative regulation of histone H3-K4 methylation;negative regulation of histone phosphorylation;negative regulation of protein localization to chromosome, telomeric region;negative regulation of protein serine/threonine kinase activity;negative regulation of response to oxidative stress;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;nucleosome assembly;positive regulation of gene expression, epigenetic;positive regulation of keratinocyte differentiation;positive regulation of maintenance of mitotic sister chromatid cohesion;positive regulation of response to oxidative stress;regulation of gene expression, epigenetic;regulation of lipid metabolic process;regulation of response to oxidative stress","chromatin DNA binding;core promoter sequence-specific DNA binding;DNA binding;double-stranded methylated DNA binding;enzyme binding;nucleosomal DNA binding;protein heterodimerization activity;protein kinase binding;protein serine/threonine kinase inhibitor activity;rDNA binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription regulatory region DNA binding","Barr body;condensed chromosome;extracellular exosome;nuclear chromatin;nuclear chromosome;nuclear chromosome, telomeric region;nucleolus;nucleosome;nucleus;pericentric heterochromatin;sex chromatin","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,1,1,1,"5.9","5.9","5.9","39.617","0.0011161","2.7636",6663500,2,"1.3019","0.33431","1.81932","4.30731","sp|O75367|H2AY_HUMAN","sp|O75367|H2AY_HUMAN",334,"O75367","H2AY_HUMAN","Core histone macro-H2A.1","H2A1;istone macroH2A1","H2AFY"]
["22.4423","22.5908","20.6528","20.8538",{"$nulls":4},"nucleosomal DNA binding","chromatin;nucleus",{"$nulls":3},3,3,3,"37.8","37.8","37.8","9.5355",0,"28.506",123230000,9,"2.30247","0.436","1.76328","14.1125","tr|A6NL93|A6NL93_HUMAN;sp|P05114|HMGN1_HUMAN;tr|A6NEL0|A6NEL0_HUMAN","tr|A6NL93|A6NL93_HUMAN;sp|P05114|HMGN1_HUMAN;tr|A6NEL0|A6NEL0_HUMAN",511,"A6NL93","A6NL93_HUMAN",null,null,"HMGN1"]
["24.6759","24.5598","23.0334","22.8579",{"$nulls":3},"antibacterial humoral response;antimicrobial humoral immune response mediated by antimicrobial peptide;defense response to Gram-positive bacterium;innate immune response in mucosa","DNA binding;protein heterodimerization activity","cytosol;extracellular space;nucleoplasm;nucleosome",{"$nulls":3},3,3,3,"26.2","26.2","26.2","13.906",0,"28.377",597920000,14,"2.4052","0.481039","1.67218","15.8971","tr|B2R4S9|B2R4S9_HUMAN;sp|Q99880|H2B1L_HUMAN;sp|Q99879|H2B1M_HUMAN;sp|Q99877|H2B1N_HUMAN;sp|Q93079|H2B1H_HUMAN;sp|Q5QNW6|H2B2F_HUMAN;sp|P62807|H2B1C_HUMAN;sp|P58876|H2B1D_HUMAN;sp|P57053|H2BFS_HUMAN;sp|O60814|H2B1K_HUMAN;tr|U3KQK0|U3KQK0_HUMAN;sp|Q8N257|H2B3B_HUMAN;sp|Q16778|H2B2E_HUMAN;sp|P33778|H2B1B_HUMAN;sp|P23527|H2B1O_HUMAN;sp|P06899|H2B1J_HUMAN;sp|Q96A08|H2B1A_HUMAN","tr|B2R4S9|B2R4S9_HUMAN;sp|Q99880|H2B1L_HUMAN;sp|Q99879|H2B1M_HUMAN;sp|Q99877|H2B1N_HUMAN;sp|Q93079|H2B1H_HUMAN;sp|Q5QNW6|H2B2F_HUMAN;sp|P62807|H2B1C_HUMAN;sp|P58876|H2B1D_HUMAN;sp|P57053|H2BFS_HUMAN;sp|O60814|H2B1K_HUMAN;tr|U3KQK0|U3KQK0_HUMAN;sp|Q8N257|H2B3B_HUMAN;sp|Q16778|H2B2E_HUMAN;sp|P33778|H2B1B_HUMAN;sp|P23527|H2B1O_HUMAN;sp|P06899|H2B1J_HUMAN",306,"B2R4S9","B2R4S9_HUMAN","Histone H2B {ECO:0000256|RuleBase:RU000451}",null,"HIST1H2BC"]
["20.4992","20.4188","18.8958","19.0106",{"$nulls":3},"mRNA splicing, via spliceosome;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA processing","pre-mRNA intronic binding;RNA binding;transcription regulatory region DNA binding","cytoplasm;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus;ribonucleoprotein granule",{"$nulls":3},3,3,2,"11.9","11.9","10.4","64.132",0,"23.534",109560000,13,"2.66592","0.586105","1.50585","21.4911","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN",676,"P14866","HNRPL_HUMAN","Heterogeneous nuclear ribonucleoprotein L","nRNP L","HNRNPL"]
["22.4484","22.8131","21.1649","21.1426",{"$nulls":9},1,1,1,"38.7","38.7","38.7","6.1895",0,"43.17",55133000,5,"1.82513","0.383886","1.47697","8.08447","tr|C9JLG5|C9JLG5_HUMAN;tr|C9JA65|C9JA65_HUMAN;sp|O00458|IFRD1_HUMAN","tr|C9JLG5|C9JLG5_HUMAN;tr|C9JA65|C9JA65_HUMAN;sp|O00458|IFRD1_HUMAN",144,"C9JLG5","C9JLG5_HUMAN",null,null,"IFRD1"]
["18.53","18.4394","17.2448","17.1128",{"$nulls":3},"mitochondrial ATP synthesis coupled proton transport;mitochondrial electron transport, ubiquinol to cytochrome c;response to glucagon","electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity;electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity;heme binding;metal ion binding","integral component of membrane;membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrion;nucleus","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,2,2,2,"19.7","19.7","19.7","35.422",0,"21.145",33687000,6,"2.42762","0.487027","1.3059","16.3151","sp|P08574|CY1_HUMAN","sp|P08574|CY1_HUMAN",564,"P08574","CY1_HUMAN","Cytochrome c1, heme protein, mitochondrial",null,"CYC1"]
["19.2201","19.2101","18.0775","17.7674",{"$nulls":3},"neutrophil degranulation","heme binding;steroid binding","cell body;endoplasmic reticulum;extracellular exosome;integral component of plasma membrane;membrane;neuron projection;neuronal cell body;plasma membrane;smooth endoplasmic reticulum membrane;specific granule membrane;synapse",{"$nulls":3},4,4,4,"37.9","37.9","37.9","21.671",0,"95.548",23899000,7,"1.8507","0.386667","1.29267","8.33144","sp|O00264|PGRC1_HUMAN","sp|O00264|PGRC1_HUMAN",130,"O00264","PGRC1_HUMAN","Membrane-associated progesterone receptor component 1","PR","PGRMC1"]
["20.8665","20.6207","19.2559","19.6715",{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,"13.7","13.7","13.7","31.745",0,"9.7485",129610000,7,"1.47119","0.323429","1.27987","5.3011","tr|H0Y6E7|H0Y6E7_HUMAN;tr|H3BT71|H3BT71_HUMAN;sp|P38159|RBMX_HUMAN;tr|H3BR27|H3BR27_HUMAN;sp|Q96E39|RMXL1_HUMAN;tr|H3BNC1|H3BNC1_HUMAN;sp|O75526|RMXL2_HUMAN;sp|Q8N7X1|RMXL3_HUMAN","tr|H0Y6E7|H0Y6E7_HUMAN;tr|H3BT71|H3BT71_HUMAN;sp|P38159|RBMX_HUMAN;tr|H3BR27|H3BR27_HUMAN;sp|Q96E39|RMXL1_HUMAN",957,"H0Y6E7","H0Y6E7_HUMAN",null,null,"RBMX"]
["20.0327","19.9549","18.7609","18.865",{"$nulls":3},"N-acetylneuraminate metabolic process","N-acylneuraminate cytidylyltransferase activity","membrane;nucleoplasm;nucleus","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,4,4,4,15,15,15,"48.379",0,"9.2632",131440000,16,"2.52098","0.515294","1.18087","18.1764","sp|Q8NFW8|NEUA_HUMAN","sp|Q8NFW8|NEUA_HUMAN",2098,"Q8NFW8","NEUA_HUMAN","N-acylneuraminate cytidylyltransferase",null,"CMAS"]
["16.5801","16.3638","15.3957","15.3159",{"$nulls":3},"ribosomal small subunit biogenesis;rRNA modification;tRNA acetylation","ATP binding;N-acetyltransferase activity","nucleolus",{"$nulls":3},1,1,1,"1.8","1.8","1.8","93.533",0,"20.83",16562000,3,"1.979","0.410102","1.1161","9.68414","tr|A0A087WV29|A0A087WV29_HUMAN;sp|Q9H0A0|NAT10_HUMAN","tr|A0A087WV29|A0A087WV29_HUMAN;sp|Q9H0A0|NAT10_HUMAN",2553,"A0A087WV29","A0A087WV29_HUMAN","RNA cytidine acetyltransferase {ECO:0000256|HAMAP-Rule:MF_03211}",null,"NAT10"]
["15.1635","14.9023","14.0786","13.8145",{"$nulls":3},"chromatin organization;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;neural tube development;neurogenesis;nuclear pore distribution;nuclear pore organization;paraxial mesoderm development;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of transcription, DNA-templated;sister chromatid cohesion;somite development;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;tRNA export from nucleus;viral process;viral transcription","nucleocytoplasmic transporter activity;structural constituent of nuclear pore","condensed chromosome kinetochore;cytosol;host cell;membrane;nuclear envelope;nuclear membrane;nuclear pore;nuclear pore outer ring","RNA transport",null,null,1,1,1,"0.8","0.8","0.8","128.98","0.002771","2.1727",12978000,3,"1.55276","0.330667","1.08636","5.84936","sp|Q8WUM0|NU133_HUMAN","sp|Q8WUM0|NU133_HUMAN",2140,"Q8WUM0","NU133_HUMAN","Nuclear pore complex protein Nup133",null,"NUP133"]
["20.8715","21.0247","20.1331","19.6953",{"$nulls":3},"carbohydrate metabolic process;neutrophil degranulation;protein folding","carbohydrate binding;enzyme binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;plasma membrane;specific granule membrane",{"$nulls":3},4,4,4,"14.7","14.7","14.7","32.233",0,"90.268",167990000,20,"1.32961","0.333869","1.03393","4.45783","sp|Q14165|MLEC_HUMAN;tr|F5H1S8|F5H1S8_HUMAN;tr|F5GX14|F5GX14_HUMAN;tr|H0YG07|H0YG07_HUMAN","sp|Q14165|MLEC_HUMAN;tr|F5H1S8|F5H1S8_HUMAN;tr|F5GX14|F5GX14_HUMAN",1607,"Q14165","MLEC_HUMAN","Malectin",null,"MLEC"]
["17.7095","17.6238","16.4897","16.8275",{"$nulls":3},"L-methionine salvage from methylthioadenosine","identical protein binding;S-methyl-5-thioribose-1-phosphate isomerase activity","cell projection;cytosol;fibrillar center;nucleoplasm","Cysteine and methionine metabolism;Metabolic pathways",null,null,2,2,2,"8.1","8.1","8.1","39.149","0.0011152","2.758",37570000,2,"1.54356","0.320145","1.00804","5.78499","sp|Q9BV20|MTNA_HUMAN","sp|Q9BV20|MTNA_HUMAN",2463,"Q9BV20","MTNA_HUMAN","Methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119}","1Pi {ECO:0000255|HAMAP-Rule:MF_03119};TR-1-P isomerase {ECO:0000255|HAMAP-Rule:MF_03119}","MRI1"]
[]
["17.0474","17.1457","18.2147","17.9811",{"$nulls":3},"intracellular signal transduction","GTPase activator activity;metal ion binding","intracellular",{"$nulls":3},1,1,1,"2.3","2.3","2.3","84.622",0,"55.292",50523000,9,"1.80572","0.365605","-1.00135","-7.90162","tr|K7ES92|K7ES92_HUMAN;tr|F5H1R4|F5H1R4_HUMAN;sp|Q92619|HMHA1_HUMAN;tr|K7ES98|K7ES98_HUMAN;tr|K7EM85|K7EM85_HUMAN","tr|K7ES92|K7ES92_HUMAN;tr|F5H1R4|F5H1R4_HUMAN;sp|Q92619|HMHA1_HUMAN;tr|K7ES98|K7ES98_HUMAN;tr|K7EM85|K7EM85_HUMAN",2180,"K7ES92","K7ES92_HUMAN",null,null,"ARHGAP45"]
["17.583","17.5269","18.7234","18.4022",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},1,1,1,15,15,15,"14.056",0,"3.9186",19582000,9,"1.59896","0.338193","-1.00791","-6.18236","tr|K7EKI4|K7EKI4_HUMAN;tr|K7ELF1|K7ELF1_HUMAN;tr|K7ELQ0|K7ELQ0_HUMAN;tr|K7ES61|K7ES61_HUMAN;sp|Q9BYD3|RM04_HUMAN;tr|X6RAY8|X6RAY8_HUMAN","tr|K7EKI4|K7EKI4_HUMAN;tr|K7ELF1|K7ELF1_HUMAN;tr|K7ELQ0|K7ELQ0_HUMAN;tr|K7ES61|K7ES61_HUMAN;sp|Q9BYD3|RM04_HUMAN;tr|X6RAY8|X6RAY8_HUMAN",2508,"K7EKI4","K7EKI4_HUMAN",null,null,"MRPL4"]
["19.1749","18.9185","20.259","19.8684",{"$nulls":3},"defense response to virus;innate immune response;negative regulation of viral genome replication;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-beta production;positive regulation of mRNA catabolic process;positive regulation of RIG-I signaling pathway;response to virus","cadherin binding;metal ion binding;RNA binding","cytoplasm;cytosol;nucleus",{"$nulls":3},10,10,10,"16.2","16.2","16.2","101.43",0,"252.23",462810000,43,"1.31043","0.335144","-1.01699","-4.35317","sp|Q7Z2W4|ZCCHV_HUMAN;tr|C9J6P4|C9J6P4_HUMAN;tr|H7C5K1|H7C5K1_HUMAN","sp|Q7Z2W4|ZCCHV_HUMAN;tr|C9J6P4|C9J6P4_HUMAN",1943,"Q7Z2W4","ZCCHV_HUMAN","Zinc finger CCCH-type antiviral protein 1",null,"ZC3HAV1"]
["18.4609","18.542","19.6922","19.3476",{"$nulls":3},"response to virus;RNA processing",null,"nucleoplasm",{"$nulls":3},4,4,4,"7.5","7.5","7.5","71.611",0,"9.0463",165700000,16,"1.53918","0.315839","-1.01849","-5.7546","tr|M0R3F1|M0R3F1_HUMAN;tr|A0A0A0MRA5|A0A0A0MRA5_HUMAN;tr|B7Z4B8|B7Z4B8_HUMAN;sp|Q9BUJ2|HNRL1_HUMAN;tr|M0QYM5|M0QYM5_HUMAN;tr|M0QYI8|M0QYI8_HUMAN;tr|M0QYZ0|M0QYZ0_HUMAN","tr|M0R3F1|M0R3F1_HUMAN;tr|A0A0A0MRA5|A0A0A0MRA5_HUMAN;tr|B7Z4B8|B7Z4B8_HUMAN;sp|Q9BUJ2|HNRL1_HUMAN;tr|M0QYM5|M0QYM5_HUMAN;tr|M0QYI8|M0QYI8_HUMAN;tr|M0QYZ0|M0QYZ0_HUMAN",2455,"M0R3F1","M0R3F1_HUMAN",null,null,"HNRNPUL1"]
["19.363","19.2131","20.2302","20.3976",{"$nulls":3},"cell division;kinetochore organization;meiotic chromosome condensation;meiotic chromosome segregation;mitotic chromosome condensation;mitotic sister chromatid segregation","ATP binding;protein heterodimerization activity","condensin complex;cytosol;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},19,19,19,"20.7","20.7","20.7","147.18",0,"116.03",1006500000,65,"1.9289","0.397854","-1.02586","-9.13246","sp|Q9NTJ3|SMC4_HUMAN;tr|E9PD53|E9PD53_HUMAN;tr|C9JR83|C9JR83_HUMAN;tr|C9JVD8|C9JVD8_HUMAN;tr|C9J578|C9J578_HUMAN;tr|C9J9E4|C9J9E4_HUMAN;tr|C9JWF0|C9JWF0_HUMAN;tr|C9IYK2|C9IYK2_HUMAN;tr|C9JJ64|C9JJ64_HUMAN","sp|Q9NTJ3|SMC4_HUMAN;tr|E9PD53|E9PD53_HUMAN",2698,"Q9NTJ3","SMC4_HUMAN","Structural maintenance of chromosomes protein 4","MC protein 4;MC-4","SMC4"]
["18.9344","19.1207","19.9663","20.1425",{"$nulls":9},2,2,2,"19.1","19.1","19.1","15.175",0,"42.332",98434000,13,"1.8173","0.381163","-1.02687","-8.01021","tr|F8WBJ6|F8WBJ6_HUMAN;sp|Q9NRX1|PNO1_HUMAN","tr|F8WBJ6|F8WBJ6_HUMAN;sp|Q9NRX1|PNO1_HUMAN",2685,"F8WBJ6","F8WBJ6_HUMAN",null,null,"PNO1"]
["17.9628","17.6505","18.9844","18.7502",{"$nulls":3},"determination of adult lifespan;DNA repair;intrinsic apoptotic signaling pathway;intrinsic apoptotic signaling pathway in response to DNA damage;isotype switching;meiotic mismatch repair;mismatch repair;negative regulation of DNA recombination;positive regulation of helicase activity;positive regulation of isotype switching;response to UV;somatic hypermutation of immunoglobulin genes;somatic recombination of immunoglobulin gene segments;viral process","ATP binding;chromatin binding;damaged DNA binding;DNA-dependent ATPase activity;guanine/thymine mispair binding;methylated histone binding;mismatched DNA binding","cytosol;Golgi apparatus;intracellular membrane-bounded organelle;MutSalpha complex;nuclear chromatin;nucleoplasm","Colorectal cancer;Mismatch repair;Pathways in cancer;Platinum drug resistance",null,null,7,7,7,"7.8","7.8","7.8","152.78",0,"13.675",319090000,30,"1.49162","0.324168","-1.06067","-5.43385","sp|P52701|MSH6_HUMAN;tr|A0A087WWJ1|A0A087WWJ1_HUMAN;tr|F8W7G9|F8W7G9_HUMAN;tr|F8WAX8|F8WAX8_HUMAN;tr|A0A087WYT6|A0A087WYT6_HUMAN","sp|P52701|MSH6_HUMAN;tr|A0A087WWJ1|A0A087WWJ1_HUMAN",1162,"P52701","MSH6_HUMAN","DNA mismatch repair protein Msh6 {ECO:0000250|UniProtKB:P54276}","MSH6 {ECO:0000303|PubMed:8942985}","MSH6"]
["19.9993","20.3065","21.164","21.2864",{"$nulls":9},2,2,2,"34.6","34.6","34.6","9.2555",0,"5.6918",76960000,14,"1.63913","0.326495","-1.07227","-6.48611","tr|F5GYQ2|F5GYQ2_HUMAN;tr|F5GX77|F5GX77_HUMAN;sp|Q9UI30|TR112_HUMAN","tr|F5GYQ2|F5GYQ2_HUMAN;tr|F5GX77|F5GX77_HUMAN;sp|Q9UI30|TR112_HUMAN",2847,"F5GYQ2","F5GYQ2_HUMAN",null,null,"TRMT112"]
["19.1533","19.1352","20.4184","20.0181",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity",{"$nulls":4},5,5,5,"17.7","17.7","17.7","45.31",0,"26.275",180170000,12,"1.48031","0.3279","-1.07405","-5.35997","tr|E7EU96|E7EU96_HUMAN;sp|P68400|CSK21_HUMAN;tr|Q5U5J2|Q5U5J2_HUMAN;sp|Q8NEV1|CSK23_HUMAN;tr|V9GYA2|V9GYA2_HUMAN;tr|V9GY80|V9GY80_HUMAN","tr|E7EU96|E7EU96_HUMAN;sp|P68400|CSK21_HUMAN;tr|Q5U5J2|Q5U5J2_HUMAN;sp|Q8NEV1|CSK23_HUMAN",1361,"E7EU96","E7EU96_HUMAN",null,null,"CSNK2A1"]
["19.8549","19.6454","21.0029","20.6502",{"$nulls":3},"negative regulation of ATPase activity;ossification;protein import into mitochondrial matrix",null,"extrinsic component of mitochondrial inner membrane;mitochondrial matrix;presequence translocase-associated import motor;protein complex",{"$nulls":3},2,2,2,"24.8","24.8","24.8","13.825",0,"33.96",66692000,8,"1.46275","0.323012","-1.07642","-5.24713","sp|Q9Y3D7|TIM16_HUMAN;tr|I3L1U7|I3L1U7_HUMAN;tr|I3L0X9|I3L0X9_HUMAN;tr|I3L3T0|I3L3T0_HUMAN;tr|A0A0A6YYL4|A0A0A6YYL4_HUMAN","sp|Q9Y3D7|TIM16_HUMAN;tr|I3L1U7|I3L1U7_HUMAN;tr|I3L0X9|I3L0X9_HUMAN;tr|I3L3T0|I3L3T0_HUMAN;tr|A0A0A6YYL4|A0A0A6YYL4_HUMAN",2985,"Q9Y3D7","TIM16_HUMAN","Mitochondrial import inner membrane translocase subunit TIM16",null,"PAM16"]
["19.6085","19.6953","20.7734","20.7091",{"$nulls":3},"response to drug;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane, translocation","7S RNA binding;RNA binding;signal recognition particle binding;TPR domain binding","cytosol;endoplasmic reticulum;signal recognition particle;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,7,7,7,"15.2","15.2","15.2","74.605",0,"69.83",438500000,28,"2.61096","0.55619","-1.08933","-20.1689","sp|O76094|SRP72_HUMAN;tr|R4GNC1|R4GNC1_HUMAN;tr|D6RDY6|D6RDY6_HUMAN","sp|O76094|SRP72_HUMAN",388,"O76094","SRP72_HUMAN","Signal recognition particle subunit SRP72","RP72","SRP72"]
["17.4561","17.4309","18.6675","18.4057",{"$nulls":3},"cellular response to lithium ion;DNA ligation involved in DNA repair;DNA recombination;double-strand break repair;double-strand break repair via nonhomologous end joining;establishment of integrated proviral latency;positive regulation of ligase activity;response to X-ray","identical protein binding;protein C-terminus binding","cytosol;DNA ligase IV complex;DNA-dependent protein kinase-DNA ligase 4 complex;nonhomologous end joining complex;nucleoplasm;nucleus","Non-homologous end-joining",null,null,3,3,3,11,11,11,"38.286",0,"15.153",41022000,10,"1.84876","0.383824","-1.09311","-8.31239","sp|Q13426|XRCC4_HUMAN","sp|Q13426|XRCC4_HUMAN",1552,"Q13426","XRCC4_HUMAN","DNA repair protein XRCC4",null,"XRCC4"]
["16.8831","16.8279","17.9978","17.9087",{"$nulls":5},"acrosomal vesicle",{"$nulls":3},2,2,2,"1.3","1.3","1.3","187.02","0.0010737","2.3967",141510000,3,"2.6434","0.584678","-1.09773","-20.9391","sp|Q9ULL0|K1210_HUMAN","sp|Q9ULL0|K1210_HUMAN",2894,"Q9ULL0","K1210_HUMAN","Acrosomal protein KIAA1210 {ECO:0000305}",null,"KIAA1210"]
["17.4356","17.2439","18.6351","18.2407",{"$nulls":9},1,1,1,"6.3","6.3","6.3","30.983","0.00039698","3.3176",22246000,7,"1.42438","0.332571","-1.09815","-5.00786","tr|E9PMR3|E9PMR3_HUMAN;sp|Q9BUR4|WAP53_HUMAN","tr|E9PMR3|E9PMR3_HUMAN;sp|Q9BUR4|WAP53_HUMAN",2461,"E9PMR3","E9PMR3_HUMAN",null,null,"WRAP53"]
["19.1278","19.0836","20.2736","20.1474",{"$nulls":3},"apoptotic process;blood circulation;cellular response to insulin stimulus;cellular response to interferon-beta;cellular response to interferon-gamma;cellular response to organic cyclic compound;defense response to virus;interferon-gamma-mediated signaling pathway;interleukin-12-mediated signaling pathway;JAK-STAT cascade;macrophage derived foam cell differentiation;metanephric mesenchymal cell differentiation;metanephric mesenchymal cell proliferation involved in metanephros development;negative regulation by virus of viral protein levels in host cell;negative regulation of angiogenesis;negative regulation of endothelial cell proliferation;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;negative regulation of metanephric nephron tubule epithelial cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of defense response to virus by host;positive regulation of erythrocyte differentiation;positive regulation of interferon-alpha production;positive regulation of mesenchymal cell proliferation;positive regulation of nitric-oxide synthase biosynthetic process;positive regulation of smooth muscle cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of apoptotic process;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway;renal tubule development;response to cAMP;response to cytokine;response to drug;response to hydrogen peroxide;response to interferon-beta;response to mechanical stimulus;response to nutrient;response to peptide hormone;transcription, DNA-templated;tumor necrosis factor-mediated signaling pathway;type I interferon signaling pathway;viral process","cadherin binding;CCR5 chemokine receptor binding;core promoter binding;DNA binding transcription factor activity;double-stranded DNA binding;enzyme binding;histone acetyltransferase binding;histone binding;identical protein binding;nuclear hormone receptor binding;promoter-specific chromatin binding;protein homodimerization activity;protein phosphatase 2A binding;repressing transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;signal transducer activity;transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;tumor necrosis factor receptor binding;ubiquitin-like protein ligase binding","axon;cytoplasm;cytosol;dendrite;nuclear chromatin;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex","AGE-RAGE signaling pathway in diabetic complications;Chemokine signaling pathway;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human papillomavirus infection;Inflammatory bowel disease (IBD);Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Prolactin signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis",null,null,9,9,9,"16.4","16.4","16.4","87.334",0,"29.029",410810000,37,"2.43893","0.500556","-1.10479","-16.5301","sp|P42224|STAT1_HUMAN;tr|J3KPM9|J3KPM9_HUMAN;tr|E7EPD2|E7EPD2_HUMAN;tr|D2KFR9|D2KFR9_HUMAN;tr|H7BZ88|H7BZ88_HUMAN;tr|H7BZB5|H7BZB5_HUMAN;tr|E7ENM1|E7ENM1_HUMAN","sp|P42224|STAT1_HUMAN;tr|J3KPM9|J3KPM9_HUMAN",992,"P42224","STAT1_HUMAN","Signal transducer and activator of transcription 1-alpha/beta",null,"STAT1"]
["18.1054","17.9685","19.3366","18.949",{"$nulls":3},"ATP-dependent chromatin remodeling;chromatin assembly or disassembly;DNA methylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;regulation of fibroblast migration;regulation of signal transduction by p53 class mediator","chromatin binding;DNA binding transcription factor activity;histone deacetylase activity;histone deacetylase binding;RNA polymerase II repressing transcription factor binding;RNA polymerase II transcription factor binding;sequence-specific DNA binding;transcription factor activity, transcription factor binding;transcription regulatory region DNA binding;zinc ion binding","histone deacetylase complex;membrane;nuclear chromatin;nucleoplasm;NuRD complex;protein complex;transcription factor complex",{"$nulls":3},4,4,4,"8.8","8.8","8.8","75.022",0,"27.245",209390000,25,"1.4834","0.325088","-1.10585","-5.38009","sp|O94776|MTA2_HUMAN","sp|O94776|MTA2_HUMAN",391,"O94776","MTA2_HUMAN","Metastasis-associated protein MTA2",null,"MTA2"]
["20.3983","20.5864","21.824","21.3757",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","cadherin binding;RNA binding","cytoplasm;membrane",{"$nulls":3},7,7,7,"12.9","12.9","12.9","48.043",0,"16.627",633430000,27,"1.34716","0.336646","-1.1075","-4.55554","sp|Q7L1Q6|BZW1_HUMAN;tr|C9IZ80|C9IZ80_HUMAN;tr|C9JFN4|C9JFN4_HUMAN;tr|C9J188|C9J188_HUMAN;tr|C9JWF5|C9JWF5_HUMAN;tr|H0Y503|H0Y503_HUMAN","sp|Q7L1Q6|BZW1_HUMAN;tr|C9IZ80|C9IZ80_HUMAN;tr|C9JFN4|C9JFN4_HUMAN",1930,"Q7L1Q6","BZW1_HUMAN","Basic leucine zipper and W2 domain-containing protein 1",null,"BZW1"]
["17.9306","17.6156","18.9769","18.8092",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;cardiac muscle cell proliferation;cellular response to glucagon stimulus;female meiotic nuclear division;intracellular signal transduction;mesoderm formation;negative regulation of activated T cell proliferation;negative regulation of cAMP-dependent protein kinase activity;negative regulation of meiotic nuclear division;regulation of transcription from RNA polymerase II promoter;renal water homeostasis;sarcomere organization","cAMP binding;cAMP-dependent protein kinase inhibitor activity;cAMP-dependent protein kinase regulator activity;protein domain specific binding;protein kinase A catalytic subunit binding;ubiquitin protein ligase binding","cAMP-dependent protein kinase complex;ciliary base;cytoplasm;cytosol;membrane;neuromuscular junction;nucleotide-activated protein kinase complex;plasma membrane raft;protein complex","Insulin signaling pathway",null,null,3,3,3,"10.8","10.8","10.8","42.981",0,"11.976",105360000,7,"1.61152","0.337202","-1.11989","-6.27593","sp|P10644|KAP0_HUMAN;tr|K7EM13|K7EM13_HUMAN;tr|K7EPB2|K7EPB2_HUMAN;tr|K7EPR5|K7EPR5_HUMAN;tr|K7EQK3|K7EQK3_HUMAN;tr|K7EMU2|K7EMU2_HUMAN;tr|X6RAV4|X6RAV4_HUMAN;tr|K7EMZ6|K7EMZ6_HUMAN;tr|K7EIE5|K7EIE5_HUMAN;tr|K7EID3|K7EID3_HUMAN;tr|K7EJ40|K7EJ40_HUMAN;tr|K7EK41|K7EK41_HUMAN","sp|P10644|KAP0_HUMAN;tr|K7EM13|K7EM13_HUMAN;tr|K7EPB2|K7EPB2_HUMAN",611,"P10644","KAP0_HUMAN","cAMP-dependent protein kinase type I-alpha regulatory subunit",null,"PRKAR1A"]
["17.1646","16.8138","18.287","17.9374",{"$nulls":3},"adaptive immune response;adherens junction organization;brain development;cell differentiation;cellular response to peptide hormone stimulus;central nervous system development;epidermal growth factor receptor signaling pathway;innate immune response;negative regulation of bone resorption;negative regulation of cell proliferation;negative regulation of ERK1 and ERK2 cascade;negative regulation of Golgi to plasma membrane protein transport;negative regulation of interleukin-6 production;negative regulation of kinase activity;negative regulation of low-density lipoprotein particle clearance;negative regulation of phagocytosis;oligodendrocyte differentiation;peptidyl-tyrosine autophosphorylation;positive regulation of MAP kinase activity;protein phosphorylation;regulation of cell proliferation;regulation of cytokine production;regulation of Fc receptor mediated stimulatory signaling pathway;T cell costimulation;T cell receptor signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding;identical protein binding;kinase activity;metal ion binding;non-membrane spanning protein tyrosine kinase activity;proline-rich region binding;protein C-terminus binding;protein kinase A catalytic subunit binding;protein phosphatase binding;protein tyrosine kinase activity;receptor binding","cell-cell junction;cytoplasm;cytosol;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane;membrane raft;plasma membrane","Epithelial cell signaling in Helicobacter pylori infection",null,null,2,2,2,"5.6","5.6","5.6","50.704",0,"3.462",56099000,7,"1.34348","0.337371","-1.12303","-4.53486","sp|P41240|CSK_HUMAN","sp|P41240|CSK_HUMAN",984,"P41240","CSK_HUMAN","Tyrosine-protein kinase CSK",null,"CSK"]
["20.2947","20.441","21.4301","21.5675",{"$nulls":9},1,1,1,"38.5","38.5","38.5","4.1316","0.00038715","3.0839",20154000,1,"2.10902","0.39028","-1.13095","-11.271","tr|H3BU01|H3BU01_HUMAN;sp|O60294|TYW4_HUMAN","tr|H3BU01|H3BU01_HUMAN;sp|O60294|TYW4_HUMAN",285,"H3BU01","H3BU01_HUMAN",null,null,"LCMT2"]
["15.13","14.8994","16.1247","16.1685",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;negative regulation of double-strand break repair;negative regulation of histone H2A K63-linked ubiquitination;protein polyubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of embryonic development","thyroid hormone receptor binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;nuclear speck;nucleoplasm;nucleus","Ubiquitin mediated proteolysis",null,null,3,3,3,"2.4","2.4","2.4","220.43",0,"22.984",46916000,17,"1.97546","0.406655","-1.13187","-9.64406","sp|Q14669|TRIPC_HUMAN;tr|H7C1L9|H7C1L9_HUMAN;tr|G5E9G6|G5E9G6_HUMAN","sp|Q14669|TRIPC_HUMAN",1635,"Q14669","TRIPC_HUMAN","E3 ubiquitin-protein ligase TRIP12",null,"TRIP12"]
["17.377","17.3929","18.7616","18.2765",{"$nulls":3},"apoptotic process;branching involved in blood vessel morphogenesis;cell differentiation involved in embryonic placenta development;cell morphogenesis;central nervous system development;endocardium development;hepatocyte apoptotic process;hippo signaling;intracellular signal transduction;keratinocyte differentiation;negative regulation of canonical Wnt signaling pathway;negative regulation of cell proliferation;negative regulation of organ growth;neural tube formation;peptidyl-serine phosphorylation;positive regulation of apoptotic process;positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;positive regulation of fat cell differentiation;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein binding;positive regulation of protein phosphorylation;primitive hemopoiesis;protein autophosphorylation;protein phosphorylation;protein stabilization;regulation of cell differentiation involved in embryonic placenta development;regulation of mitotic cell cycle;signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;identical protein binding;magnesium ion binding;protein dimerization activity;protein homodimerization activity;protein kinase activity;protein serine/threonine kinase activator activity;protein serine/threonine kinase activity;transcription factor binding","cytoplasm;cytosol;nuclear body;nucleoplasm;nucleus;protein complex","FoxO signaling pathway;MAPK signaling pathway;Non-small cell lung cancer;Pathways in cancer;Ras signaling pathway",null,null,4,4,4,"8.8","8.8","8.8","55.63",0,"8.5518",93057000,7,"1.36788","0.332058","-1.13412","-4.67321","sp|Q13043|STK4_HUMAN;tr|F5H5B4|F5H5B4_HUMAN;tr|A0A087WYT4|A0A087WYT4_HUMAN;tr|A0A087WVN8|A0A087WVN8_HUMAN;sp|Q13188|STK3_HUMAN","sp|Q13043|STK4_HUMAN;tr|F5H5B4|F5H5B4_HUMAN",1514,"Q13043","STK4_HUMAN","Serine/threonine-protein kinase 4",null,"STK4"]
["17.6276","17.7992","19.0252","18.7167",{"$nulls":3},"actin cytoskeleton reorganization;cell adhesion","actin binding",{"$nulls":4},2,2,2,"14.4","14.4","14.4","21.561","0.0047587","2.0047",34652000,4,"1.64831","0.330681","-1.15751","-6.55751","tr|B0QYP8|B0QYP8_HUMAN;tr|A0A087WZB5|A0A087WZB5_HUMAN;sp|Q9HBI1|PARVB_HUMAN","tr|B0QYP8|B0QYP8_HUMAN;tr|A0A087WZB5|A0A087WZB5_HUMAN;sp|Q9HBI1|PARVB_HUMAN",2636,"B0QYP8","B0QYP8_HUMAN",null,null,"PARVB"]
["14.4985","14.0227","15.5064","15.3644",{"$nulls":9},1,1,1,"2.3","2.3","2.3","68.12",0,"3.6251",10471000,3,"1.37813","0.333702","-1.17479","-4.73241","tr|A8MSZ8|A8MSZ8_HUMAN;tr|A6NN50|A6NN50_HUMAN;sp|O75147|OBSL1_HUMAN","tr|A8MSZ8|A8MSZ8_HUMAN;tr|A6NN50|A6NN50_HUMAN;sp|O75147|OBSL1_HUMAN",322,"A8MSZ8","A8MSZ8_HUMAN",null,null,"OBSL1"]
["17.2366","17.3881","18.6797","18.296",{"$nulls":3},"mitochondrial tRNA 3'-trailer cleavage, endonucleolytic;mitochondrial tRNA processing;tRNA 3'-end processing","3'-tRNA processing endoribonuclease activity;metal ion binding;RNA binding;tRNA-specific ribonuclease activity","mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleoplasm;nucleus","RNA transport",null,null,6,6,6,"12.1","12.1","12.1","92.218",0,"12.375",144420000,15,"1.53114","0.317867","-1.17553","-5.69922","sp|Q9BQ52|RNZ2_HUMAN;tr|E7ES68|E7ES68_HUMAN;tr|G5E9D5|G5E9D5_HUMAN;tr|H7C2I4|H7C2I4_HUMAN;tr|V9GZ72|V9GZ72_HUMAN;tr|V9GYS7|V9GYS7_HUMAN","sp|Q9BQ52|RNZ2_HUMAN;tr|E7ES68|E7ES68_HUMAN;tr|G5E9D5|G5E9D5_HUMAN",2412,"Q9BQ52","RNZ2_HUMAN","Zinc phosphodiesterase ELAC protein 2",null,"ELAC2"]
["17.1379","17.2222","18.4643","18.251",{"$nulls":3},"DNA strand elongation involved in DNA replication;DNA strand elongation involved in mitotic DNA replication;inner cell mass cell proliferation","3'-5' DNA helicase activity","cytoplasm;GINS complex;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"7.1","7.1","7.1","22.988",0,"8.9699",36995000,9,"2.02927","0.413429","-1.17761","-10.27","sp|Q14691|PSF1_HUMAN","sp|Q14691|PSF1_HUMAN",1639,"Q14691","PSF1_HUMAN","DNA replication complex GINS protein PSF1",null,"GINS1"]
["12.5471","12.9805","14.0727","13.8131",{"$nulls":3},"Golgi to endosome transport;protein transport",null,"cytosol;extracellular exosome",{"$nulls":3},1,1,1,"0.6","0.6","0.6","190.36","0.0097752","1.689",11209000,2,"1.36696","0.332817","-1.17912","-4.66797","sp|Q7Z3U7|MON2_HUMAN","sp|Q7Z3U7|MON2_HUMAN",1949,"Q7Z3U7","MON2_HUMAN","Protein MON2 homolog",null,"MON2"]
["16.9541","17.0172","18.0981","18.2389",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;ribosomal small subunit assembly","GTP binding;ribosomal small subunit binding;RNA binding;rRNA binding","cytosol;mitochondrial inner membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},1,1,1,"2.7","2.7","2.7","48.349",0,"6.6272",24828000,1,"2.37428","0.4687","-1.18285","-15.3377","sp|O75616|ERAL1_HUMAN","sp|O75616|ERAL1_HUMAN",356,"O75616","ERAL1_HUMAN","GTPase Era, mitochondrial","ERA;-ERA","ERAL1"]
["16.9972","16.9099","18.4261","17.9385",{"$nulls":3},"D-ribose metabolic process;pentose-phosphate shunt;pentose-phosphate shunt, non-oxidative branch","identical protein binding;monosaccharide binding;ribose-5-phosphate isomerase activity","cytosol;intracellular membrane-bounded organelle","Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,2,2,2,"10.3","10.3","10.3","33.269","0.00040016","3.3663",38515000,10,"1.4166","0.33165","-1.22871","-4.9606","sp|P49247|RPIA_HUMAN","sp|P49247|RPIA_HUMAN",1069,"P49247","RPIA_HUMAN","Ribose-5-phosphate isomerase",null,"RPIA"]
["13.5049","13.8007","14.7872","14.9824",{"$nulls":3},"apoptotic DNA fragmentation;conversion of ds siRNA to ss siRNA;conversion of ds siRNA to ss siRNA involved in RNA interference;miRNA loading onto RISC involved in gene silencing by miRNA;miRNA metabolic process;negative regulation of Schwann cell proliferation;negative regulation of transcription from RNA polymerase II promoter;nerve development;neuron projection morphogenesis;peripheral nervous system myelin formation;positive regulation of myelination;positive regulation of Schwann cell differentiation;pre-miRNA processing;production of miRNAs involved in gene silencing by miRNA;production of siRNA involved in RNA interference;RNA phosphodiester bond hydrolysis, endonucleolytic;siRNA loading onto RISC involved in RNA interference;targeting of mRNA for destruction involved in RNA interference","ATP binding;deoxyribonuclease I activity;DNA binding;double-stranded RNA binding;endoribonuclease activity;helicase activity;metal ion binding;pre-miRNA binding;protein domain specific binding;ribonuclease III activity;siRNA binding","ARC complex;axon;cytoplasm;cytosol;dendrite;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;growth cone;micro-ribonucleoprotein complex;nucleus;RISC-loading complex","MicroRNAs in cancer",null,null,1,1,1,"0.6","0.6","0.6","218.68",0,"6.6728",19320000,7,"1.69756","0.346462","-1.23198","-6.95292","sp|Q9UPY3|DICER_HUMAN","sp|Q9UPY3|DICER_HUMAN",2928,"Q9UPY3","DICER_HUMAN","Endoribonuclease Dicer",null,"DICER1"]
["15.5547","15.4034","17.0046","16.4592",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;aorta morphogenesis;auditory receptor cell stereocilium organization;cargo loading into COPII-coated vesicle;cochlear nucleus development;COPII vesicle coating;coronary artery morphogenesis;ER to Golgi vesicle-mediated transport;intracellular protein transport;lung lobe morphogenesis;neural tube closure;outflow tract morphogenesis;pulmonary artery morphogenesis;regulation of cargo loading into COPII-coated vesicle;regulation of establishment of planar polarity involved in neural tube closure","zinc ion binding","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane","Protein processing in endoplasmic reticulum",null,null,2,2,2,"2.6","2.6","2.6","137.42",0,"14.229",25277000,5,"1.32396","0.332301","-1.25285","-4.4268","sp|O95487|SC24B_HUMAN","sp|O95487|SC24B_HUMAN",439,"O95487","SC24B_HUMAN","Protein transport protein Sec24B {ECO:0000305}",null,"SEC24B"]
["20.2731","19.9971","21.3148","21.4737",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},5,5,5,"36.9","36.9","36.9","16.714",0,"20.739",138650000,15,"1.80642","0.36811","-1.25911","-7.90819","tr|M0R3D6|M0R3D6_HUMAN;tr|M0R1A7|M0R1A7_HUMAN;tr|M0R117|M0R117_HUMAN;sp|Q02543|RL18A_HUMAN;tr|M0R0P7|M0R0P7_HUMAN","tr|M0R3D6|M0R3D6_HUMAN;tr|M0R1A7|M0R1A7_HUMAN;tr|M0R117|M0R117_HUMAN;sp|Q02543|RL18A_HUMAN;tr|M0R0P7|M0R0P7_HUMAN",1430,"M0R3D6","M0R3D6_HUMAN",null,null,"RPL18A"]
["18.0416","18.013","19.555","19.0897",{"$nulls":9},1,1,1,"13.6","13.6","13.6","7.5737","0.0010842","2.4927",24413000,5,"1.50999","0.321207","-1.29503","-5.55573","tr|H3BUR4|H3BUR4_HUMAN;sp|Q9ULX3|NOB1_HUMAN","tr|H3BUR4|H3BUR4_HUMAN;sp|Q9ULX3|NOB1_HUMAN",2898,"H3BUR4","H3BUR4_HUMAN",null,null,"NOB1"]
["18.3218","18.0702","19.7327","19.2709",{"$nulls":3},"mitochondrial respiratory chain complex I assembly",null,"integral component of membrane;mitochondrial inner membrane",{"$nulls":3},1,1,1,"18.1","18.1","18.1","12.257","0.0050471","1.9205",16873000,6,"1.41764","0.332916","-1.30583","-4.96687","sp|Q96GE9|TM261_HUMAN","sp|Q96GE9|TM261_HUMAN",2279,"Q96GE9","DMAC1_HUMAN","Distal membrane-arm assembly complex protein 1 {ECO:0000303|PubMed:27626371}",null,"DMAC1"]
["24.2523","24.1066","25.4631","25.5461",{"$nulls":3},"amino acid transport;glutamine secretion;glutamine transport;L-glutamine import across plasma membrane;neutral amino acid transport","amino acid transmembrane transporter activity;L-glutamine transmembrane transporter activity;L-serine transmembrane transporter activity;neutral amino acid transmembrane transporter activity;receptor activity;symporter activity;virus receptor activity","extracellular exosome;integral component of plasma membrane;melanosome;membrane;plasma membrane","Central carbon metabolism in cancer;Protein digestion and absorption",null,null,10,10,10,"21.3","21.3","21.3","56.598",0,"292.71",3854200000,58,"2.40034","0.474872","-1.32515","-15.8077","sp|Q15758|AAAT_HUMAN;tr|M0QXM4|M0QXM4_HUMAN;tr|M0QX44|M0QX44_HUMAN","sp|Q15758|AAAT_HUMAN;tr|M0QXM4|M0QXM4_HUMAN",1720,"Q15758","AAAT_HUMAN","Neutral amino acid transporter B(0)","TB(0)","SLC1A5"]
["18.3293","18.2452","19.7182","19.5106",{"$nulls":3},"cell division;meiotic chromosome condensation;meiotic chromosome segregation;mitotic chromosome condensation","chromatin binding;DNA topoisomerase (ATP-hydrolyzing) activator activity;DNA topoisomerase binding","condensin complex;cytosol;membrane;nuclear condensin complex;nucleus",{"$nulls":3},10,10,10,"17.1","17.1","17.1","82.562",0,"22.618",269580000,21,"2.15173","0.41502","-1.32714","-11.8456","sp|Q15003|CND2_HUMAN;tr|E9PHA2|E9PHA2_HUMAN;tr|C9J470|C9J470_HUMAN;tr|C9JZP1|C9JZP1_HUMAN;tr|H7C415|H7C415_HUMAN","sp|Q15003|CND2_HUMAN;tr|E9PHA2|E9PHA2_HUMAN;tr|C9J470|C9J470_HUMAN",1655,"Q15003","CND2_HUMAN","Condensin complex subunit 2",null,"NCAPH"]
["22.5891","22.5832","23.9791","23.8479",{"$nulls":3},"adherens junction assembly;androgen receptor signaling pathway;anterior/posterior axis specification;beta-catenin destruction complex disassembly;beta-catenin-TCF complex assembly;bone resorption;branching involved in blood vessel morphogenesis;branching involved in ureteric bud morphogenesis;canonical Wnt signaling pathway;canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;canonical Wnt signaling pathway involved in negative regulation of apoptotic process;canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation;canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition;catenin import into nucleus;cell adhesion;cell fate specification;cell maturation;cell morphogenesis involved in differentiation;cell-cell adhesion;cell-matrix adhesion;cellular response to growth factor stimulus;cellular response to indole-3-methanol;central nervous system vasculogenesis;chemical synaptic transmission;chromatin-mediated maintenance of transcription;cranial ganglion development;cranial skeletal system development;dorsal root ganglion development;dorsal/ventral axis specification;ectoderm development;embryonic axis specification;embryonic brain development;embryonic digit morphogenesis;embryonic foregut morphogenesis;embryonic forelimb morphogenesis;embryonic heart tube development;embryonic hindlimb morphogenesis;embryonic skeletal limb joint morphogenesis;endodermal cell fate commitment;endothelial tube morphogenesis;entry of bacterium into host cell;epithelial cell differentiation involved in prostate gland development;epithelial to mesenchymal transition;epithelial tube branching involved in lung morphogenesis;fungiform papilla formation;gastrulation with mouth forming second;genitalia morphogenesis;glial cell fate determination;hair cell differentiation;hair follicle morphogenesis;hair follicle placode formation;hindbrain development;in utero embryonic development;layer formation in cerebral cortex;lens morphogenesis in camera-type eye;lung cell differentiation;lung induction;lung-associated mesenchyme development;male genitalia development;mesenchymal cell proliferation involved in lung development;metanephros morphogenesis;midbrain dopaminergic neuron differentiation;negative regulation of angiogenesis;negative regulation of apoptotic signaling pathway;negative regulation of cell death;negative regulation of cell proliferation;negative regulation of chondrocyte differentiation;negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;negative regulation of mitotic cell cycle, embryonic;negative regulation of oligodendrocyte differentiation;negative regulation of osteoclast differentiation;negative regulation of oxidative stress-induced neuron death;negative regulation of protein sumoylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;nephron tubule formation;neural plate development;neuron migration;neuron projection extension;odontogenesis of dentin-containing tooth;oocyte development;osteoclast differentiation;oviduct development;pancreas development;positive regulation of apoptotic process;positive regulation of chromatin-mediated maintenance of transcription;positive regulation of core promoter binding;positive regulation of determination of dorsal identity;positive regulation of DNA binding transcription factor activity;positive regulation of DNA-templated transcription, initiation;positive regulation of endothelial cell differentiation;positive regulation of epithelial cell proliferation involved in prostate gland development;positive regulation of epithelial to mesenchymal transition;positive regulation of fibroblast growth factor receptor signaling pathway;positive regulation of heparan sulfate proteoglycan biosynthetic process;positive regulation of histone H3-K4 methylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of MAPK cascade;positive regulation of mesenchymal cell proliferation;positive regulation of muscle cell differentiation;positive regulation of neuroblast proliferation;positive regulation of neuron apoptotic process;positive regulation of osteoblast differentiation;positive regulation of skeletal muscle tissue development;positive regulation of telomerase activity;positive regulation of telomere maintenance via telomerase;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;proteasome-mediated ubiquitin-dependent protein catabolic process;protein localization to cell surface;proximal/distal pattern formation;regulation of angiogenesis;regulation of calcium ion import;regulation of centriole-centriole cohesion;regulation of centromeric sister chromatid cohesion;regulation of euchromatin binding;regulation of fibroblast proliferation;regulation of myelination;regulation of nephron tubule epithelial cell differentiation;regulation of neurogenesis;regulation of protein localization to cell surface;regulation of secondary heart field cardioblast proliferation;regulation of smooth muscle cell proliferation;regulation of T cell proliferation;regulation of timing of anagen;renal inner medulla development;renal outer medulla development;renal vesicle formation;response to drug;response to estradiol;smooth muscle cell differentiation;stem cell population maintenance;sympathetic ganglion development;synapse organization;synaptic vesicle transport;T cell differentiation in thymus;thymus development;trachea formation;transcription, DNA-templated;Wnt signaling pathway;Wnt signaling pathway, calcium modulating pathway","alpha-catenin binding;androgen receptor binding;cadherin binding;chromatin binding;disordered domain specific binding;DNA binding transcription factor activity;enzyme binding;estrogen receptor binding;ion channel binding;I-SMAD binding;kinase binding;nuclear hormone receptor binding;protein C-terminus binding;protein heterodimerization activity;protein kinase binding;protein phosphatase binding;repressing transcription factor binding;RNA polymerase II activating transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription factor binding;signal transducer activity;SMAD binding;transcription coactivator activity;transcription factor binding;transcription regulatory region DNA binding","adherens junction;apical part of cell;basolateral plasma membrane;beta-catenin destruction complex;beta-catenin-TCF complex;beta-catenin-TCF7L2 complex;bicellular tight junction;catenin complex;cell cortex;cell junction;cell periphery;cell-cell adherens junction;cell-cell junction;centrosome;cytoplasm;cytosol;extracellular exosome;fascia adherens;flotillin complex;focal adhesion;intracellular;lamellipodium;lateral plasma membrane;membrane;microvillus membrane;nuclear euchromatin;nucleoplasm;nucleus;perinuclear region of cytoplasm;plasma membrane;protein complex;protein-DNA complex;Scrib-APC-beta-catenin complex;spindle pole;synapse;transcription factor complex;Wnt signalosome;Z disc","Adherens junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Basal cell carcinoma;Breast cancer;Colorectal cancer;Cushing syndrome;Endometrial cancer;Fluid shear stress and atherosclerosis;Focal adhesion;Gastric cancer;Hepatitis C;Hepatocellular carcinoma;Hippo signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Melanogenesis;Pathogenic Escherichia coli infection;Pathways in cancer;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Signaling pathways regulating pluripotency of stem cells;Thyroid cancer;Thyroid hormone signaling pathway;Wnt signaling pathway",null,null,20,20,19,"41.2","41.2","39.6","85.496",0,"323.31",6085100000,156,"2.61251","0.565161","-1.32731","-20.205","sp|P35222|CTNB1_HUMAN;tr|B4DGU4|B4DGU4_HUMAN;tr|E7EMJ5|E7EMJ5_HUMAN;tr|E9PDF9|E9PDF9_HUMAN;tr|E7EV28|E7EV28_HUMAN;tr|C9IZ65|C9IZ65_HUMAN","sp|P35222|CTNB1_HUMAN;tr|B4DGU4|B4DGU4_HUMAN",921,"P35222","CTNB1_HUMAN","Catenin beta-1",null,"CTNNB1"]
["18.4644","18.0484","19.5727","19.6245",{"$nulls":9},1,1,1,"37.9","37.9","37.9","11.246",0,"33.738",21819000,1,"1.62829","0.325915","-1.3422","-6.40282","tr|K7EJQ6|K7EJQ6_HUMAN;tr|K7ERQ0|K7ERQ0_HUMAN;tr|K7ERY2|K7ERY2_HUMAN;tr|K7EPQ7|K7EPQ7_HUMAN;sp|Q5BJH7|YIF1B_HUMAN","tr|K7EJQ6|K7EJQ6_HUMAN;tr|K7ERQ0|K7ERQ0_HUMAN;tr|K7ERY2|K7ERY2_HUMAN;tr|K7EPQ7|K7EPQ7_HUMAN;sp|Q5BJH7|YIF1B_HUMAN",1803,"K7EJQ6","K7EJQ6_HUMAN",null,null,"YIF1B"]
["20.7103","20.3036","21.9661","21.7655",{"$nulls":3},"mitochondrion organization;positive regulation of transcription from RNA polymerase II promoter;regulation of cellular response to hypoxia;transcription, DNA-templated","sequence-specific DNA binding;transcription factor binding","mitochondrial intermembrane space;mitochondrion;nucleus",{"$nulls":3},3,3,3,"27.2","27.2","27.2","15.512",0,"30.766",134650000,12,"1.57302","0.329739","-1.35883","-5.99327","sp|Q9Y6H1|CHCH2_HUMAN;sp|Q5T1J5|CHCH9_HUMAN","sp|Q9Y6H1|CHCH2_HUMAN;sp|Q5T1J5|CHCH9_HUMAN",1829,"Q9Y6H1","CHCH2_HUMAN","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2",null,"CHCHD2"]
["15.4714","15.5137","16.6011","17.1089",{"$nulls":3},"hair follicle maturation;neurogenesis;ribosomal small subunit biogenesis","RNA binding","nucleolus;nucleus",{"$nulls":3},1,1,1,"1.5","1.5","1.5","96.256",0,"22.755",30367000,9,"1.47836","0.328797","-1.36244","-5.34733","sp|Q5C9Z4|NOM1_HUMAN","sp|Q5C9Z4|NOM1_HUMAN",1804,"Q5C9Z4","NOM1_HUMAN","Nucleolar MIF4G domain-containing protein 1",null,"NOM1"]
["17.7653","17.4368","19.0504","18.8822",{"$nulls":3},"folic acid metabolic process;one-carbon metabolic process;tetrahydrofolate metabolic process","magnesium ion binding;methenyltetrahydrofolate cyclohydrolase activity;methylenetetrahydrofolate dehydrogenase (NAD+) activity;methylenetetrahydrofolate dehydrogenase (NADP+) activity;phosphate ion binding","extracellular space;mitochondrial matrix;mitochondrion","Metabolic pathways;One carbon pool by folate",null,null,4,4,4,18,18,18,"37.895",0,"4.8743",103130000,12,"1.75009","0.352713","-1.36528","-7.39933","sp|P13995|MTDC_HUMAN;tr|B9A062|B9A062_HUMAN","sp|P13995|MTDC_HUMAN",666,"P13995","MTDC_HUMAN","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial",null,"MTHFD2"]
["17.9281","17.5842","19.1092","19.1352",{"$nulls":3},"exocyst localization;Golgi to plasma membrane transport;negative regulation of exocytosis;regulation of SNARE complex assembly","cadherin binding involved in cell-cell adhesion;GTP-Rho binding;phosphatidylinositol-4,5-bisphosphate binding","cell-cell adherens junction;exocyst;integral component of membrane;plasma membrane",{"$nulls":3},1,1,1,"5.7","5.7","5.7","23.554",0,"9.0569",71411000,2,"1.80795","0.370648","-1.366","-7.92249","sp|Q8NFX7|STXB6_HUMAN","sp|Q8NFX7|STXB6_HUMAN",2099,"Q8NFX7","STXB6_HUMAN","Syntaxin-binding protein 6",null,"STXBP6"]
["15.0316","15.3836","16.8084","16.341",{"$nulls":4},"GTPase activator activity",{"$nulls":4},1,1,1,3,3,3,"43.347",0,"6.4098",11190000,1,"1.3679","0.333256","-1.36711","-4.67337","tr|H0Y873|H0Y873_HUMAN;sp|Q96P47|AGAP3_HUMAN","tr|H0Y873|H0Y873_HUMAN;sp|Q96P47|AGAP3_HUMAN",2331,"H0Y873","H0Y873_HUMAN",null,null,"AGAP3"]
["17.002","16.7798","17.9738","18.5564",{"$nulls":4},"cadherin binding;identical protein binding","cytoplasm;cytosol;nucleoplasm","Endocytosis",null,null,3,3,3,"10.1","10.1","10.1","43.973",0,"12.182",53716000,5,"1.32046","0.333741","-1.3742","-4.40763","sp|Q9NR46|SHLB2_HUMAN;tr|B7ZC38|B7ZC38_HUMAN;tr|B7ZC39|B7ZC39_HUMAN;tr|F8WFB9|F8WFB9_HUMAN","sp|Q9NR46|SHLB2_HUMAN;tr|B7ZC38|B7ZC38_HUMAN;tr|B7ZC39|B7ZC39_HUMAN",2680,"Q9NR46","SHLB2_HUMAN","Endophilin-B2",null,"SH3GLB2"]
["16.6102","16.7116","18.4012","17.7698",{"$nulls":3},"cell division;chromosome separation;meiotic chromosome condensation;mitotic chromosome condensation","chromatin binding;histone binding","condensed chromosome;condensed chromosome, centromeric region;condensin complex;condensin core heterodimer;cytoplasm;cytosol;membrane;nuclear condensin complex;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"7.2","7.2","7.2","157.18",0,"25.008",193730000,31,"1.32916","0.334593","-1.42461","-4.45539","sp|Q15021|CND1_HUMAN;tr|E7EN77|E7EN77_HUMAN;tr|F5H431|F5H431_HUMAN;tr|F5GZK7|F5GZK7_HUMAN","sp|Q15021|CND1_HUMAN;tr|E7EN77|E7EN77_HUMAN",1664,"Q15021","CND1_HUMAN","Condensin complex subunit 1",null,"NCAPD2"]
["15.2717","15.0365","16.5129","16.6486",{"$nulls":3},"phosphatidylinositol dephosphorylation","hydrolase activity","cytosol",{"$nulls":3},2,1,1,"2.7","1.5","1.5","90.559",0,"4.9854",22443000,3,"2.04889","0.413045","-1.42666","-10.508","tr|H0Y5Q9|H0Y5Q9_HUMAN;sp|Q92835|SHIP1_HUMAN","tr|H0Y5Q9|H0Y5Q9_HUMAN;sp|Q92835|SHIP1_HUMAN",2195,"H0Y5Q9","H0Y5Q9_HUMAN",null,null,"INPP5D"]
["19.536","19.2894","20.9266","20.756",{"$nulls":3},"chromatin silencing at telomere;DNA packaging;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;histone H4 acetylation;internal protein amino acid acetylation;response to nutrient","H4 histone acetyltransferase activity;histone acetyltransferase activity;histone binding","cytoplasm;intracellular membrane-bounded organelle;nuclear chromatin;nuclear chromosome, telomeric region;nuclear matrix;nucleoplasm;nucleus;protein complex","Alcoholism",null,null,5,5,5,"16.9","16.9","16.9","49.512",0,"20.722",226550000,28,"1.96497","0.399934","-1.42857","-9.52643","sp|O14929|HAT1_HUMAN;tr|F8WEW1|F8WEW1_HUMAN;tr|F8W9G7|F8W9G7_HUMAN","sp|O14929|HAT1_HUMAN",182,"O14929","HAT1_HUMAN","Histone acetyltransferase type B catalytic subunit",null,"HAT1"]
["16.0982","15.9051","17.6908","17.2206",{"$nulls":3},"CMP salvage;CTP salvage;pyrimidine nucleobase metabolic process;pyrimidine nucleoside salvage;UMP salvage","ATP binding;nucleoside kinase activity;uridine kinase activity","cytosol","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,1,1,1,5,5,5,"29.299","0.00075672","2.8713",20473000,4,"1.5343","0.316857","-1.45405","-5.7209","sp|Q9BZX2|UCK2_HUMAN","sp|Q9BZX2|UCK2_HUMAN",2525,"Q9BZX2","UCK2_HUMAN","Uridine-cytidine kinase 2","CK 2","UCK2"]
["17.0147","17.1951","18.6179","18.515",{"$nulls":3},"endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosome assembly;rRNA processing","GTP binding;GTPase activity;RNA binding;U3 snoRNA binding","cytosol;nucleolus;nucleoplasm;preribosome, small subunit precursor",{"$nulls":3},4,4,4,"9.8","9.8","9.8","91.809",0,"8.5598",117370000,15,"2.29996","0.430989","-1.4616","-14.0715","sp|Q2NL82|TSR1_HUMAN;tr|I3L1Q5|I3L1Q5_HUMAN","sp|Q2NL82|TSR1_HUMAN;tr|I3L1Q5|I3L1Q5_HUMAN",1772,"Q2NL82","TSR1_HUMAN","Pre-rRNA-processing protein TSR1 homolog",null,"TSR1"]
["19.3703","19.2997","20.8823","20.7152",{"$nulls":3},"establishment of endothelial intestinal barrier;hippo signaling;intestinal absorption;negative regulation of osteoclast development;regulation of membrane permeability;TNFSF11-mediated signaling pathway","cadherin binding;guanylate kinase activity;protein binding, bridging;protein C-terminus binding;protein domain specific binding","adherens junction;bicellular tight junction;cell junction;cytosol;nucleoplasm;plasma membrane","Tight junction;Vibrio cholerae infection",null,null,11,11,11,"14.5","14.5","14.5","133.96",0,"155.99",747820000,24,"2.41818","0.480533","-1.46381","-16.1377","sp|Q9UDY2|ZO2_HUMAN;tr|U3KQJ2|U3KQJ2_HUMAN;tr|B1AN86|B1AN86_HUMAN","sp|Q9UDY2|ZO2_HUMAN",2817,"Q9UDY2","ZO2_HUMAN","Tight junction protein ZO-2",null,"TJP2"]
["18.6665","18.5523","20.3184","19.833",{"$nulls":9},1,1,1,"24.7","24.7","24.7","8.2873",0,"3.6942",32458000,8,"1.55728","0.333801","-1.46631","-5.88117","tr|D6R918|D6R918_HUMAN;tr|D6RBC5|D6RBC5_HUMAN;tr|D6RDI5|D6RDI5_HUMAN;tr|D6RA54|D6RA54_HUMAN;tr|D6RC55|D6RC55_HUMAN;tr|D6RG39|D6RG39_HUMAN;tr|D6RIT9|D6RIT9_HUMAN;sp|Q9NX40|OCAD1_HUMAN","tr|D6R918|D6R918_HUMAN;tr|D6RBC5|D6RBC5_HUMAN;tr|D6RDI5|D6RDI5_HUMAN;tr|D6RA54|D6RA54_HUMAN;tr|D6RC55|D6RC55_HUMAN;tr|D6RG39|D6RG39_HUMAN;tr|D6RIT9|D6RIT9_HUMAN;sp|Q9NX40|OCAD1_HUMAN",2734,"D6R918","D6R918_HUMAN",null,null,"OCIAD1"]
["17.7302","17.7542","19.116","19.3022",{"$nulls":3},"DNA biosynthetic process;DNA ligation involved in DNA repair;DNA recombination;DNA replication","ATP binding;DNA binding;DNA ligase (ATP) activity",{"$nulls":4},10,10,10,"17.5","17.5","17.5","88.386",0,"51.023",240580000,26,"2.39052","0.474633","-1.46687","-15.629","tr|M0R0Q7|M0R0Q7_HUMAN;sp|P18858|DNLI1_HUMAN;tr|B4E135|B4E135_HUMAN;tr|F5GZ28|F5GZ28_HUMAN;tr|M0QY71|M0QY71_HUMAN;tr|M0R1G7|M0R1G7_HUMAN","tr|M0R0Q7|M0R0Q7_HUMAN;sp|P18858|DNLI1_HUMAN;tr|B4E135|B4E135_HUMAN;tr|F5GZ28|F5GZ28_HUMAN",725,"M0R0Q7","M0R0Q7_HUMAN","DNA ligase {ECO:0000256|RuleBase:RU000617}",null,"LIG1"]
["15.6171","15.9356","17.392","17.1585",{"$nulls":3},"contact inhibition;negative regulation of cell growth;negative regulation of cell migration;negative regulation of cell proliferation;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of MAP kinase activity;negative regulation of platelet-derived growth factor receptor signaling pathway;negative regulation of protein kinase B signaling;negative regulation of T cell receptor signaling pathway;negative regulation of vascular permeability;neutrophil degranulation;peptidyl-tyrosine dephosphorylation;platelet-derived growth factor receptor signaling pathway;positive chemotaxis;positive regulation of cell adhesion;positive regulation of focal adhesion assembly;positive regulation of protein kinase B signaling;regulation of cell adhesion;T cell receptor signaling pathway","beta-catenin binding;delta-catenin binding;gamma-catenin binding;mitogen-activated protein kinase binding;phosphatase activity;platelet-derived growth factor receptor binding;protein kinase binding;protein tyrosine phosphatase activity","cell surface;cell-cell junction;extracellular exosome;immunological synapse;integral component of plasma membrane;plasma membrane;ruffle membrane;specific granule membrane","Adherens junction",null,null,3,3,3,"3.9","3.9","3.9","145.94",0,"4.557",49055000,10,"1.7716","0.359584","-1.49891","-7.58989","sp|Q12913|PTPRJ_HUMAN;tr|A0A087WTK0|A0A087WTK0_HUMAN;tr|A0A087WVC6|A0A087WVC6_HUMAN","sp|Q12913|PTPRJ_HUMAN;tr|A0A087WTK0|A0A087WTK0_HUMAN;tr|A0A087WVC6|A0A087WVC6_HUMAN",1507,"Q12913","PTPRJ_HUMAN","Receptor-type tyrosine-protein phosphatase eta",{"$error":"#NAME?"},"PTPRJ"]
["15.2448","15.0768","16.793","16.5502",{"$nulls":3},"negative regulation of cell migration;positive regulation of anion channel activity;positive regulation of protein targeting to membrane","ion channel binding","plasma membrane",{"$nulls":3},1,1,1,"1.3","1.3","1.3","102.12",0,"13.38",34810000,6,"2.02628","0.40977","-1.51077","-10.2343","sp|Q9Y4C2|TCAF1_HUMAN","sp|Q9Y4C2|TCAF1_HUMAN",2995,"Q9Y4C2","TCAF1_HUMAN","TRPM8 channel-associated factor 1 {ECO:0000303|PubMed:25559186}",null,"TCAF1"]
["18.489","18.2903","20.2249","19.6482",{"$nulls":3},"RNA processing","RNA binding","mitochondrion",{"$nulls":3},7,7,7,"27.1","27.1","27.1","47.27",0,"45.023",182140000,17,"1.43485","0.332693","-1.54693","-5.07219","tr|H0Y8R1|H0Y8R1_HUMAN;tr|F5H5I6|F5H5I6_HUMAN;tr|H0YAK1|H0YAK1_HUMAN;sp|Q12849|GRSF1_HUMAN;tr|H0YAM1|H0YAM1_HUMAN","tr|H0Y8R1|H0Y8R1_HUMAN;tr|F5H5I6|F5H5I6_HUMAN;tr|H0YAK1|H0YAK1_HUMAN;sp|Q12849|GRSF1_HUMAN",1500,"H0Y8R1","H0Y8R1_HUMAN",null,null,"GRSF1"]
["16.4369","16.5364","17.8717","18.2024",{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},1,1,1,7,7,7,"25.477","0.0075833","1.763",23207000,5,"1.91425","0.39584","-1.55038","-8.97695","tr|M0QX71|M0QX71_HUMAN;sp|Q9BQ67|GRWD1_HUMAN","tr|M0QX71|M0QX71_HUMAN;sp|Q9BQ67|GRWD1_HUMAN",2414,"M0QX71","M0QX71_HUMAN",null,null,"GRWD1"]
["19.6545","19.7679","21.3054","21.4345",{"$nulls":3},"DNA metabolic process;intracellular transport of virus;modulation by virus of host process;NLS-bearing protein import into nucleus;regulation of DNA recombination","histone deacetylase binding;nuclear localization sequence binding;protein transporter activity;RNA binding","cytoplasm;cytosol;host cell;membrane;nuclear pore;nucleoplasm","Influenza A",null,null,7,7,7,"20.2","20.2","20.2","57.861",0,"155.51",705800000,46,"2.5736","0.539077","-1.65873","-19.3166","sp|P52292|IMA1_HUMAN;tr|J3QLL0|J3QLL0_HUMAN;tr|J3KS65|J3KS65_HUMAN;tr|J3QL07|J3QL07_HUMAN","sp|P52292|IMA1_HUMAN;tr|J3QLL0|J3QLL0_HUMAN;tr|J3KS65|J3KS65_HUMAN",1153,"P52292","IMA1_HUMAN","Importin subunit alpha-1",null,"KPNA2"]
["16.4282","15.8552","18.035","17.7627",{"$nulls":3},"COPII vesicle coating;G1/S transition of mitotic cell cycle;innate immune response;protein dephosphorylation","metal ion binding;protein serine/threonine phosphatase activity","cytosol;Golgi membrane;mitochondrion",{"$nulls":3},2,2,2,"8.9","8.9","8.9","35.144",0,"5.0332",23846000,6,"1.50744","0.322163","-1.75714","-5.53867","sp|O00743|PPP6_HUMAN;tr|Q5T1S7|Q5T1S7_HUMAN","sp|O00743|PPP6_HUMAN;tr|Q5T1S7|Q5T1S7_HUMAN",155,"O00743","PPP6_HUMAN","Serine/threonine-protein phosphatase 6 catalytic subunit","P6C","PPP6C"]
["15.1073","14.9048","17.0698","16.682",{"$nulls":3},"mRNA export from nucleus;regulation of gene expression;RNA secondary structure unwinding;RNA splicing","ATP binding;ATP-dependent RNA helicase activity;helicase activity;RNA binding","catalytic step 2 spliceosome;cytoplasm;extracellular exosome;membrane;nuclear envelope;nuclear membrane;nuclear pore;nucleolus",{"$nulls":3},6,1,1,15,"5.6","5.6","53.926","0.00040128","3.3969",17937000,4,"1.87238","0.387212","-1.86982","-8.54646","sp|Q9UMR2|DD19B_HUMAN;tr|H3BQK0|H3BQK0_HUMAN;tr|H3BMQ5|H3BMQ5_HUMAN;tr|H3BN59|H3BN59_HUMAN","sp|Q9UMR2|DD19B_HUMAN;tr|H3BQK0|H3BQK0_HUMAN;tr|H3BMQ5|H3BMQ5_HUMAN;tr|H3BN59|H3BN59_HUMAN",2901,"Q9UMR2","DD19B_HUMAN","ATP-dependent RNA helicase DDX19B",null,"DDX19B"]
["13.6956","13.8056","15.7696","15.5279",{"$nulls":3},"adherens junction maintenance;brain morphogenesis;cerebral cortex development;homeostasis of number of cells;neuroepithelial cell differentiation;protein localization to cell junction;radial glial cell differentiation;regulation of oligodendrocyte progenitor proliferation;signal transduction","cell adhesion molecule binding","apical junction complex;apical part of cell;cell junction;cell-cell adherens junction;cytosol;nuclear speck;nucleoplasm;plasma membrane","Adherens junction;cAMP signaling pathway;Leukocyte transendothelial migration;Rap1 signaling pathway;Ras signaling pathway;Tight junction",null,null,2,2,2,"1.6","1.6","1.6","201.8","0.0010945","2.5624",19724000,3,"2.31361","0.451759","-1.89813","-14.2961","tr|A8MQ02|A8MQ02_HUMAN;sp|P55196|AFAD_HUMAN;tr|J3KN01|J3KN01_HUMAN;tr|H0Y8U8|H0Y8U8_HUMAN;tr|H0Y948|H0Y948_HUMAN;tr|H0Y8L4|H0Y8L4_HUMAN;tr|Q5TIG5|Q5TIG5_HUMAN","tr|A8MQ02|A8MQ02_HUMAN;sp|P55196|AFAD_HUMAN;tr|J3KN01|J3KN01_HUMAN;tr|H0Y8U8|H0Y8U8_HUMAN;tr|H0Y948|H0Y948_HUMAN;tr|H0Y8L4|H0Y8L4_HUMAN;tr|Q5TIG5|Q5TIG5_HUMAN",1207,"A8MQ02","A8MQ02_HUMAN",null,null,"AFDN"]
["17.7062","18.2788","20.3237","19.8474",{"$nulls":9},2,2,2,"10.9","10.9","10.9","24.992",0,"9.9866",73837000,10,"1.51964","0.32531","-2.09302","-5.62079","sp|Q9H7E9|CH033_HUMAN","sp|Q9H7E9|CH033_HUMAN",2610,"Q9H7E9","CH033_HUMAN","UPF0488 protein C8orf33",null,"C8orf33"]
["17.5196","17.5201","20.0577","19.2868",{"$nulls":3},"cell proliferation in forebrain;deoxyribonucleotide biosynthetic process;DNA replication;male gonad development;mitotic cell cycle;nucleobase-containing small molecule interconversion;protein heterotetramerization;pyrimidine nucleobase metabolic process;response to ionizing radiation;retina development in camera-type eye","ATP binding;disordered domain specific binding;identical protein binding;ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor","cell projection;cytosol;extracellular exosome;neuronal cell body;nuclear envelope;ribonucleoside-diphosphate reductase complex","Drug metabolism - other enzymes;Glutathione metabolism;Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,6,6,6,"11.5","11.5","11.5","90.069",0,"242.82",366550000,33,"1.51417","0.322597","-2.1524","-5.58385","sp|P23921|RIR1_HUMAN;tr|E9PL69|E9PL69_HUMAN","sp|P23921|RIR1_HUMAN;tr|E9PL69|E9PL69_HUMAN",787,"P23921","RIR1_HUMAN","Ribonucleoside-diphosphate reductase large subunit",null,"RRM1"]
["16.4826","16.105","18.5811","18.3796",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},3,3,3,"8.1","8.1","8.1","59.544",0,"22.643",75547000,15,"2.02498","0.406175","-2.18656","-10.2188","sp|Q86XZ4|SPAS2_HUMAN;tr|F8VS10|F8VS10_HUMAN","sp|Q86XZ4|SPAS2_HUMAN;tr|F8VS10|F8VS10_HUMAN",1998,"Q86XZ4","SPAS2_HUMAN","Spermatogenesis-associated serine-rich protein 2",null,"SPATS2"]
["15.7999","15.6826","18.1631","17.7249",{"$nulls":3},"cell proliferation;mitochondrial calcium ion transmembrane transport;mitochondrial protein catabolic process;mitochondrial protein processing;mitochondrion organization;negative regulation of apoptotic process;protein hexamerization;protein quality control for misfolded or incompletely synthesized proteins","ATP binding;ATP-dependent peptidase activity;metal ion binding;metalloendopeptidase activity;metallopeptidase activity","integral component of membrane;membrane;mitochondrial inner membrane;mitochondrion;nuclear body",{"$nulls":3},3,3,3,"6.3","6.3","6.3","86.454",0,"72.942",77700000,13,"1.9814","0.413607","-2.20275","-9.7114","sp|Q96TA2|YMEL1_HUMAN;tr|Q96I63|Q96I63_HUMAN","sp|Q96TA2|YMEL1_HUMAN;tr|Q96I63|Q96I63_HUMAN",2365,"Q96TA2","YMEL1_HUMAN","ATP-dependent zinc metalloprotease YME1L1",null,"YME1L1"]
["14.624","15.0469","17.459","16.7241",{"$nulls":3},"intracellular protein transport;toxin transport;vesicle-mediated transport",null,"actin filament;AP-3 adaptor complex;CORVET complex;early endosome",{"$nulls":3},2,2,2,"3.5","3.5","3.5","107.81",0,"9.3497",35144000,6,"1.47445","0.326091","-2.25614","-5.32206","tr|A0A087WXL6|A0A087WXL6_HUMAN;sp|Q9H270|VPS11_HUMAN;tr|A0A0G2JS92|A0A0G2JS92_HUMAN;tr|B7Z879|B7Z879_HUMAN","tr|A0A087WXL6|A0A087WXL6_HUMAN;sp|Q9H270|VPS11_HUMAN;tr|A0A0G2JS92|A0A0G2JS92_HUMAN;tr|B7Z879|B7Z879_HUMAN",2573,"A0A087WXL6","A0A087WXL6_HUMAN",null,null,"VPS11"]
["16.2258","16.2483","18.7933","18.3925",{"$nulls":9},2,2,2,"3.4","3.4","3.4","78.346",0,"3.8289",78344000,3,"2.14381","0.40672","-2.35585","-11.7369","tr|E9PC74|E9PC74_HUMAN;sp|Q13144|EI2BE_HUMAN","tr|E9PC74|E9PC74_HUMAN;sp|Q13144|EI2BE_HUMAN",1526,"E9PC74",{"$nulls":3},"EIF2B5"]
["17.4664","17.6006","20.0519","19.7457",{"$nulls":3},"cell division","ATP binding;protein serine/threonine kinase activity","cytosol;nucleus",{"$nulls":3},6,6,5,"22.2","22.2","18.5","34.081",0,"12.916",228610000,23,"2.3047","0.441129","-2.36529","-14.1491","tr|A0A024QZP7|A0A024QZP7_HUMAN;sp|P06493|CDK1_HUMAN;tr|E5RIU6|E5RIU6_HUMAN;tr|A0A087WZZ9|A0A087WZZ9_HUMAN;tr|G3V317|G3V317_HUMAN;tr|K7ELV5|K7ELV5_HUMAN;sp|Q00526|CDK3_HUMAN","tr|A0A024QZP7|A0A024QZP7_HUMAN;sp|P06493|CDK1_HUMAN;tr|E5RIU6|E5RIU6_HUMAN;tr|A0A087WZZ9|A0A087WZZ9_HUMAN",528,"A0A024QZP7","A0A024QZP7_HUMAN",null,null,"CDK1"]
["18.5215","18.7145","20.8939","21.0958",{"$nulls":3},"axon regeneration;dihydrofolate metabolic process;folic acid metabolic process;glycine biosynthetic process;negative regulation of translation;nucleotide biosynthetic process;one-carbon metabolic process;oxidation-reduction process;positive regulation of nitric-oxide synthase activity;regulation of removal of superoxide radicals;regulation of transcription involved in G1/S transition of mitotic cell cycle;response to methotrexate;tetrahydrobiopterin biosynthetic process;tetrahydrofolate biosynthetic process;tetrahydrofolate metabolic process","dihydrofolate reductase activity;drug binding;folate reductase activity;folic acid binding;methotrexate binding;mRNA binding;NADPH binding;sequence-specific mRNA binding;translation repressor activity, nucleic acid binding","cytosol;mitochondrion","Antifolate resistance;Folate biosynthesis;Metabolic pathways;One carbon pool by folate",null,null,3,3,3,"23.5","23.5","23.5","21.452",0,"10.792",176050000,13,"2.4639","0.501183","-2.37685","-17.0148","sp|P00374|DYR_HUMAN;tr|B4DM58|B4DM58_HUMAN","sp|P00374|DYR_HUMAN",464,"P00374","DYR_HUMAN","Dihydrofolate reductase",null,"DHFR"]
["12.8146","12.5998","15.1502","15.1297",{"$nulls":3},"cell differentiation","RNA binding",{"$nulls":4},2,2,2,"1.5","1.5","1.5","242.96",0,"4.371",20971000,9,"2.70749","0.569455","-2.43276","-22.5479","sp|Q5JSZ5|PRC2B_HUMAN;tr|H0Y412|H0Y412_HUMAN","sp|Q5JSZ5|PRC2B_HUMAN;tr|H0Y412|H0Y412_HUMAN",1813,"Q5JSZ5","PRC2B_HUMAN","Protein PRRC2B",null,"PRRC2B"]
["17.2709","17.3292","19.8864","19.5883",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;mitotic cell cycle checkpoint;mitotic sister chromatid segregation;mitotic spindle assembly checkpoint;negative regulation of apoptotic process;negative regulation of mitotic cell cycle;negative regulation of protein catabolic process;negative regulation of ubiquitin protein ligase activity;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;sister chromatid cohesion","identical protein binding;protein homodimerization activity","condensed chromosome kinetochore;cytosol;kinetochore;mitotic spindle;nucleoplasm;nucleus;perinuclear region of cytoplasm;spindle pole","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation",null,null,3,3,3,"15.1","15.1","15.1","23.51",0,"5.4625",94218000,8,"2.41325","0.480211","-2.43727","-16.0459","sp|Q13257|MD2L1_HUMAN","sp|Q13257|MD2L1_HUMAN",1537,"Q13257","MD2L1_HUMAN","Mitotic spindle assembly checkpoint protein MAD2A","sMAD2","MAD2L1"]
["19.179","18.7115","21.5911","21.2675",{"$nulls":3},"cargo loading into vesicle;COPI coating of Golgi vesicle;COPI-coated vesicle budding;COPII vesicle coating;ER to Golgi vesicle-mediated transport;Golgi organization;intracellular protein transport;kidney development;protein oligomerization;regulated exocytosis;regulation of amyloid-beta formation;response to alkaloid;retrograde vesicle-mediated transport, Golgi to ER;vesicle targeting, to, from or within Golgi","protein complex binding;syntaxin binding","cis-Golgi network;COPI-coated vesicle;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;ER to Golgi transport vesicle membrane;extracellular exosome;gamma-secretase complex;Golgi apparatus;Golgi membrane;integral component of membrane;melanosome;plasma membrane;secretory granule membrane;trans-Golgi network transport vesicle;transport vesicle;zymogen granule membrane",{"$nulls":3},4,4,4,"27.9","27.9","27.9","24.976",0,"25.817",212110000,20,"1.89115","0.395062","-2.48401","-8.73694","sp|P49755|TMEDA_HUMAN;tr|G3V2K7|G3V2K7_HUMAN","sp|P49755|TMEDA_HUMAN;tr|G3V2K7|G3V2K7_HUMAN",1091,"P49755","TMEDA_HUMAN","Transmembrane emp24 domain-containing protein 10",null,"TMED10"]
["16.2531","16.4976","19.0705","18.7113",{"$nulls":3},"apoptotic process;protein localization","actin binding","cytoskeleton;cytosol;focal adhesion",{"$nulls":3},5,5,5,"12.2","12.2","12.2","76.763",0,"13.941",103450000,12,"2.13211","0.404078","-2.51554","-11.5782","sp|Q8IZW8|TENS4_HUMAN","sp|Q8IZW8|TENS4_HUMAN",2031,"Q8IZW8","TENS4_HUMAN","Tensin-4",null,"TNS4"]
["13.9128","13.2979","15.8604","16.5107",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell division;chromosome segregation;microtubule-based movement;mitotic cell cycle;mitotic centrosome separation;mitotic spindle assembly;mitotic spindle organization;regulation of mitotic centrosome separation;retrograde vesicle-mediated transport, Golgi to ER;spindle organization","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;microtubule binding;microtubule motor activity;protein complex binding;protein kinase binding","cytosol;kinesin complex;membrane;microtubule;spindle;spindle pole",{"$nulls":3},3,3,3,"3.4","3.4","3.4","119.16",0,"6.3703",62364000,5,"1.54085","0.318697","-2.58018","-5.76616","sp|P52732|KIF11_HUMAN","sp|P52732|KIF11_HUMAN",1163,"P52732","KIF11_HUMAN","Kinesin-like protein KIF11",null,"KIF11"]
["15.587","15.9872","18.2406","18.5786",{"$nulls":3},"cellular response to UV;mitotic cell cycle;negative regulation of inflammatory response;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of stress-activated MAPK cascade","ATP binding;protein serine/threonine kinase activity","nucleus",{"$nulls":3},2,2,2,"6.5","6.5","6.5","36.085",0,"5.1467",96866000,8,"2.0075","0.403103","-2.62253","-10.0122","sp|Q96KB5|TOPK_HUMAN;tr|E5RFX4|E5RFX4_HUMAN","sp|Q96KB5|TOPK_HUMAN;tr|E5RFX4|E5RFX4_HUMAN",2317,"Q96KB5","TOPK_HUMAN","Lymphokine-activated killer T-cell-originated protein kinase",null,"PBK"]
["18.3649","17.5819","20.8207","20.5429",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;membrane;nucleoplasm","Ribosome",null,null,2,2,2,"24.2","24.2","24.2","14.515",0,"98.827",50021000,11,"1.64348","0.331847","-2.70839","-6.51986","sp|P25398|RS12_HUMAN","sp|P25398|RS12_HUMAN",796,"P25398","RS12_HUMAN","40S ribosomal protein S12",null,"RPS12"]
["15.4715","15.1325","18.5507","17.8806",{"$nulls":3},"apoptotic process;regulation of apoptotic process;Rho protein signal transduction;septin cytoskeleton organization;signal transduction","GTP binding;GTPase inhibitor activity;GTP-Rho binding","cytosol",{"$nulls":3},2,2,2,"7.1","7.1","7.1","62.667",0,"9.8048",49515000,10,"1.7903","0.368","-2.91368","-7.7593","sp|Q9BST9|RTKN_HUMAN","sp|Q9BST9|RTKN_HUMAN",2438,"Q9BST9","RTKN_HUMAN","Rhotekin",null,"RTKN"]
["15.1189","14.3319","17.4773","17.8125",{"$nulls":3},"cell cycle;cell division;lymphocyte proliferation;maintenance of DNA methylation;methylation-dependent chromatin silencing;multicellular organism development;pericentric heterochromatin assembly;transcription, DNA-templated","ATP binding;helicase activity","chromosome, centromeric region;nucleus;pericentric heterochromatin",{"$nulls":3},3,3,3,"4.3","4.3","4.3","97.073",0,"43.479",58401000,11,"1.68203","0.343581","-2.91952","-6.82588","sp|Q9NRZ9|HELLS_HUMAN;tr|A0A0B4J1V9|A0A0B4J1V9_HUMAN;tr|A0A087WSW7|A0A087WSW7_HUMAN;tr|F6XU50|F6XU50_HUMAN;tr|B1ALG6|B1ALG6_HUMAN;tr|Q9NW36|Q9NW36_HUMAN","sp|Q9NRZ9|HELLS_HUMAN;tr|A0A0B4J1V9|A0A0B4J1V9_HUMAN;tr|A0A087WSW7|A0A087WSW7_HUMAN;tr|F6XU50|F6XU50_HUMAN",2689,"Q9NRZ9","HELLS_HUMAN","Lymphoid-specific helicase",null,"HELLS"]
["15.5753","15.1036","18.2952","18.5506",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;cellular response to fatty acid;cellular response to hypoxia;cellular response to iron(III) ion;cellular response to organic cyclic compound;digestive tract development;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;G2/M transition of mitotic cell cycle;histone H3-S10 phosphorylation involved in chromosome condensation;in utero embryonic development;mitotic metaphase plate congression;mitotic nuclear envelope disassembly;mitotic spindle organization;negative regulation of gene expression;negative regulation of protein phosphorylation;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;oocyte maturation;positive regulation of attachment of spindle microtubules to kinetochore;positive regulation of cardiac muscle cell proliferation;positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle;positive regulation of fibroblast proliferation;positive regulation of histone phosphorylation;positive regulation of mitochondrial ATP synthesis coupled electron transport;positive regulation of mitotic cell cycle;positive regulation of mRNA 3'-end processing;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;protein complex assembly;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of cell cycle;regulation of chromosome condensation;regulation of mitotic cell cycle spindle assembly checkpoint;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;response to DDT;response to drug;response to mechanical stimulus;spermatogenesis;tissue regeneration;transcription initiation from RNA polymerase II promoter;ventricular cardiac muscle cell development","cyclin-dependent protein serine/threonine kinase activator activity;cyclin-dependent protein serine/threonine kinase activity;histone kinase activity;patched binding;protein kinase binding;ubiquitin-like protein ligase binding","centrosome;condensed nuclear chromosome outer kinetochore;cyclin B1-CDK1 complex;cytoplasm;cytosol;membrane;mitochondrial matrix;nucleoplasm;nucleus;spindle pole","Cell cycle;Cellular senescence;FoxO signaling pathway;Human immunodeficiency virus 1 infection;Oocyte meiosis;p53 signaling pathway;Progesterone-mediated oocyte maturation",null,null,2,2,2,"6.5","6.5","6.5","48.337",0,"17.294",50281000,9,"2.12605","0.397714","-3.0835","-11.4968","sp|P14635|CCNB1_HUMAN;tr|E9PC90|E9PC90_HUMAN","sp|P14635|CCNB1_HUMAN;tr|E9PC90|E9PC90_HUMAN",672,"P14635","CCNB1_HUMAN","G2/mitotic-specific cyclin-B1",null,"CCNB1"]
["16.134","16.5961","19.4868","19.8145",{"$nulls":3},"deoxyribonucleotide biosynthetic process;DNA replication;negative regulation of G0 to G1 transition;nucleobase-containing small molecule interconversion;regulation of transcription involved in G1/S transition of mitotic cell cycle","metal ion binding;ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor","cytosol;ribonucleoside-diphosphate reductase complex","Drug metabolism - other enzymes;Glutathione metabolism;Metabolic pathways;p53 signaling pathway;Purine metabolism;Pyrimidine metabolism",null,null,10,10,10,"29.8","29.8","29.8","44.877",0,"19.515",303700000,21,"2.13381","0.408079","-3.28557","-11.6012","sp|P31350|RIR2_HUMAN;tr|C9JXC1|C9JXC1_HUMAN;tr|A0A0C4DGZ6|A0A0C4DGZ6_HUMAN;sp|Q7LG56|RIR2B_HUMAN;tr|H0YAV1|H0YAV1_HUMAN","sp|P31350|RIR2_HUMAN;tr|C9JXC1|C9JXC1_HUMAN",886,"P31350","RIR2_HUMAN","Ribonucleoside-diphosphate reductase subunit M2",null,"RRM2"]
["13.0818","13.3365","16.8811","16.6618",{"$nulls":3},"actin filament organization;asymmetric neuroblast division;cell morphogenesis;cellular hyperosmotic response;cellular response to muramyl dipeptide;cellular response to tumor necrosis factor;establishment of mitotic spindle orientation;G-protein coupled receptor signaling pathway;innate immune response;intracellular protein transport;intracellular signal transduction;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;negative regulation of microtubule depolymerization;negative regulation of necroptotic process;negative regulation of neurogenesis;negative regulation of podosome assembly;positive regulation of apoptotic process;positive regulation of interleukin-6 production;positive regulation of neuron differentiation;positive regulation of neuron migration;positive regulation of NF-kappaB transcription factor activity;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor production;regulation of cell proliferation;regulation of Rho protein signal transduction;regulation of small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity;microtubule binding;Rac GTPase binding;Rac guanyl-nucleotide exchange factor activity;Rho GTPase binding;Rho guanyl-nucleotide exchange factor activity;transcription factor binding;zinc ion binding","bicellular tight junction;cytoplasm;cytoplasmic vesicle;cytoskeleton;cytosol;dendritic shaft;focal adhesion;Golgi apparatus;microtubule;neuronal cell body;podosome;postsynaptic density;protein complex;ruffle membrane;spindle;vesicle","Fluid shear stress and atherosclerosis;Pathogenic Escherichia coli infection;Tight junction",null,null,2,2,2,"2.4","2.4","2.4","111.54","0.00076307","2.9448",33729000,2,"2.65396","0.594759","-3.56228","-21.1962","sp|Q92974|ARHG2_HUMAN;tr|V9GYM8|V9GYM8_HUMAN;tr|Q5VY93|Q5VY93_HUMAN","sp|Q92974|ARHG2_HUMAN;tr|V9GYM8|V9GYM8_HUMAN;tr|Q5VY93|Q5VY93_HUMAN",2209,"Q92974","ARHG2_HUMAN","Rho guanine nucleotide exchange factor 2",null,"ARHGEF2"]
[1,1,"14.1396","13.3051",{"$nulls":3},"cell proliferation;mitotic chromosome movement towards spindle pole;positive regulation of mitotic metaphase/anaphase transition;protein complex assembly;signaling","phosphoprotein phosphatase activity","cytosol;microtubule organizing center;mitochondrion;nucleus;spindle pole centrosome",{"$nulls":3},2,2,2,"3.7","3.7","3.7","95.114",0,"3.9374",11649000,3,"2.96897","0.505412","-12.7223","-30.4885","sp|Q15398|DLGP5_HUMAN","sp|Q15398|DLGP5_HUMAN",1699,"Q15398","DLGP5_HUMAN","Disks large-associated protein 5","AP-5","DLGAP5"]
[1,1,"15.4377","13.0535",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"1.3","1.3","1.3",240,"0.00040323","3.4267",8789800,2,"2.09676","0.406","-13.2456","-11.1112","tr|F8W6X9|F8W6X9_HUMAN;tr|A0A087WTQ6|A0A087WTQ6_HUMAN;sp|Q7Z5N4|SDK1_HUMAN","tr|F8W6X9|F8W6X9_HUMAN;tr|A0A087WTQ6|A0A087WTQ6_HUMAN;sp|Q7Z5N4|SDK1_HUMAN",1961,"F8W6X9","F8W6X9_HUMAN",null,null,"SDK1"]
[1,1,"14.1156","14.7505",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;apoptotic process;cell division;cell proliferation;meiotic sister chromatid cohesion, centromeric;metaphase/anaphase transition of mitotic cell cycle;mitotic cell cycle;mitotic cell cycle checkpoint;mitotic spindle assembly checkpoint;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein localization to kinetochore;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;sister chromatid cohesion","ATP binding;protein kinase activity;protein serine/threonine kinase activity","anaphase-promoting complex;condensed chromosome kinetochore;condensed chromosome outer kinetochore;condensed nuclear chromosome kinetochore;cytoplasm;cytosol;kinetochore;microtubule organizing center;perinuclear region of cytoplasm;spindle midzone","Cell cycle;Human T-cell leukemia virus 1 infection",null,null,1,1,1,"1.1","1.1","1.1","119.54","0.004717","1.9282",9576000,1,"3.25338","0.429091","-13.4331","-42.3165","sp|O60566|BUB1B_HUMAN","sp|O60566|BUB1B_HUMAN",294,"O60566","BUB1B_HUMAN","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta",null,"BUB1B"]
[1,1,"14.4628","14.5864",{"$nulls":3},"DNA methylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;regulation of RNA polymerase II transcriptional preinitiation complex assembly;transcription, DNA-templated;viral process","ATPase activity;transcription corepressor activity","cytosol;nuclear body;nucleoplasm;nucleus;transcription factor complex",{"$nulls":3},1,1,1,"1.1","1.1","1.1","136.39","0.0020942","2.2288",4763400,1,"4.6802","0.524444","-13.5246","-218.822","sp|Q6VMQ6|MCAF1_HUMAN","sp|Q6VMQ6|MCAF1_HUMAN",1907,"Q6VMQ6","MCAF1_HUMAN","Activating transcription factor 7-interacting protein 1",null,"ATF7IP"]
[1,1,"15.2691","14.4331",{"$nulls":3},"cell differentiation;cell migration;innate immune response;interferon-gamma-mediated signaling pathway;interleukin-12-mediated signaling pathway;interleukin-15-mediated signaling pathway;interleukin-2-mediated signaling pathway;interleukin-7-mediated signaling pathway;interleukin-9-mediated signaling pathway;intracellular signal transduction;MAPK cascade;peptidyl-tyrosine autophosphorylation;positive regulation of sprouting angiogenesis;protein phosphorylation;regulation of cell proliferation;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway;response to antibiotic;transmembrane receptor protein tyrosine kinase signaling pathway;type I interferon signaling pathway","ATP binding;CCR5 chemokine receptor binding;growth hormone receptor binding;metal ion binding;non-membrane spanning protein tyrosine kinase activity;protein phosphatase binding;protein tyrosine kinase activity;Ras guanyl-nucleotide exchange factor activity;receptor binding;ubiquitin protein ligase binding","cytoplasm;cytoskeleton;cytosol;endosome;extrinsic component of cytoplasmic side of plasma membrane;focal adhesion;nucleus","EGFR tyrosine kinase inhibitor resistance;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Signaling pathways regulating pluripotency of stem cells;Th1 and Th2 cell differentiation;Th17 cell differentiation;Toxoplasmosis;Tuberculosis;Viral carcinogenesis",null,null,1,1,1,"1.3","1.3","1.3","133.28","0.0072751","1.7907",17349000,2,"3.04129","0.490553","-13.8511","-33.1396","sp|P23458|JAK1_HUMAN","sp|P23458|JAK1_HUMAN",780,"P23458","JAK1_HUMAN","Tyrosine-protein kinase JAK1",null,"JAK1"]
[1,1,"14.8393","15.184",{"$nulls":3},"cell division;microtubule bundle formation;mitotic metaphase plate congression;negative regulation of cell growth;positive regulation of cyclin-dependent protein serine/threonine kinase activity;positive regulation of microtubule polymerization;positive regulation of transcription, DNA-templated;regulation of mitotic spindle organization","microtubule binding","cytoplasm;cytosol;microtubule cytoskeleton;midbody;nucleoplasm;spindle;spindle pole",{"$nulls":3},1,1,1,"3.9","3.9","3.9","38.796","0.0014011","2.2548",5772700,2,"3.8203","0.355333","-14.0116","-81.3019","sp|Q6PGN9|PSRC1_HUMAN","sp|Q6PGN9|PSRC1_HUMAN",1892,"Q6PGN9","PSRC1_HUMAN","Proline/serine-rich coiled-coil protein 1",null,"PSRC1"]
[1,1,"15.0398","15.4844",{"$nulls":3},"autophagy of peroxisome","fatty-acyl-CoA binding;lipid binding","integral component of membrane;nucleoplasm;nucleus;peroxisome",{"$nulls":3},1,1,1,"3.6","3.6","3.6","58.792","0.007292","1.8131",3467300,2,"3.61463","0.431143","-14.2621","-64.1559","tr|B7Z2R7|B7Z2R7_HUMAN","tr|B7Z2R7|B7Z2R7_HUMAN",3071,"B7Z2R7","B7Z2R7_HUMAN","Acyl-CoA-binding domain-containing protein 5 {ECO:0000256|PIRNR:PIRNR002412}",null,"ACBD5"]
[1,1,"15.7033","15.4928",{"$nulls":3},"intracellular signal transduction;negative regulation of protein tyrosine kinase activity;signal transduction","protein kinase inhibitor activity;SH3 domain binding","cytoplasm;mitochondrion",{"$nulls":3},1,1,1,"3.3","3.3","3.3","50.424","0.0010676","2.3794",8269100,2,"4.28411","0.309647","-14.5981","-138.688","sp|O60239|3BP5_HUMAN","sp|O60239|3BP5_HUMAN",281,"O60239","3BP5_HUMAN","SH3 domain-binding protein 5","H3BP-5","SH3BP5"]
[1,1,"15.9745","15.387",{"$nulls":3},"microtubule cytoskeleton organization","structural molecule activity","cytosol;microtubule cytoskeleton;spindle",{"$nulls":3},2,2,2,"4.9","4.9","4.9","92.819",0,"4.6864",15671000,6,"3.39792","0.40973","-14.6808","-49.984","sp|Q3KQU3|MA7D1_HUMAN;tr|E9PLH3|E9PLH3_HUMAN;tr|C9JIR3|C9JIR3_HUMAN;tr|H0YF21|H0YF21_HUMAN","sp|Q3KQU3|MA7D1_HUMAN;tr|E9PLH3|E9PLH3_HUMAN;tr|C9JIR3|C9JIR3_HUMAN;tr|H0YF21|H0YF21_HUMAN",1779,"Q3KQU3","MA7D1_HUMAN","MAP7 domain-containing protein 1",null,"MAP7D1"]
[1,1,"16.0836","16.0069",{"$nulls":3},"cell division;regulation of attachment of spindle microtubules to kinetochore",{"$nulls":5},1,1,1,5,5,5,"27.165","0.00039714","3.3187",10831000,1,"5.18695","0.408","-15.0453","-392.167","tr|J3KTQ0|J3KTQ0_HUMAN;sp|Q96R06|SPAG5_HUMAN","tr|J3KTQ0|J3KTQ0_HUMAN;sp|Q96R06|SPAG5_HUMAN",2341,"J3KTQ0","J3KTQ0_HUMAN",null,null,"SPAG5"]
[1,1,"17.2332","15.4632",{"$nulls":9},1,1,1,"2.2","2.2","2.2","51.911","0.0047668","2.0085",6213300,4,"2.48038","0.508343","-15.3482","-17.3424","tr|X6R9L0|X6R9L0_HUMAN;sp|Q13217|DNJC3_HUMAN","tr|X6R9L0|X6R9L0_HUMAN;sp|Q13217|DNJC3_HUMAN",1534,"X6R9L0","X6R9L0_HUMAN",null,null,"DNAJC3"]
[1,1,"16.6799","16.6671",{"$nulls":3},"phosphorelay signal transduction system","signal transducer activity","intracellular",{"$nulls":3},1,1,1,"5.1","5.1","5.1","23.693",0,"12.776",11941000,4,"6.77563",1,"-15.6735","-2442.39","tr|C9JSE3|C9JSE3_HUMAN;sp|O15287|FANCG_HUMAN","tr|C9JSE3|C9JSE3_HUMAN;sp|O15287|FANCG_HUMAN",210,"C9JSE3","C9JSE3_HUMAN",null,null,"FANCG"]
[1,1,"16.9519","16.5176",{"$nulls":3},"Cajal body organization",{"$nulls":5},1,1,1,"5.8","5.8","5.8","30.813","0.0010913","2.5404",7230500,3,"3.72033","0.422462","-15.7347","-72.4611","tr|G3V179|G3V179_HUMAN;tr|E9PMJ2|E9PMJ2_HUMAN;tr|J3KP39|J3KP39_HUMAN;sp|Q9BPY3|F118B_HUMAN","tr|G3V179|G3V179_HUMAN;tr|E9PMJ2|E9PMJ2_HUMAN;tr|J3KP39|J3KP39_HUMAN;sp|Q9BPY3|F118B_HUMAN",2409,"G3V179","G3V179_HUMAN",null,null,"FAM118B"]
[1,1,"16.0577","17.8095",{"$nulls":3},"branching morphogenesis of an epithelial tube;cell cycle phase transition;cell division;cellular response to bleomycin;cellular response to cisplatin;cellular response to DNA damage stimulus;cellular response to hydroxyurea;circadian rhythm;detection of abiotic stimulus;DNA replication;lung development;morphogenesis of an epithelium;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of double-strand break repair;regulation of circadian rhythm;response to abiotic stimulus;transcription, DNA-templated","protein heterodimerization activity;protein homodimerization activity","nuclear chromatin;nucleoplasm;nucleus",{"$nulls":3},1,1,1,"1.1","1.1","1.1","138.66",0,"16.035",77828000,7,"2.52169","0.522985","-15.9336","-18.1914","sp|Q9UNS1|TIM_HUMAN","sp|Q9UNS1|TIM_HUMAN",2916,"Q9UNS1","TIM_HUMAN","Protein timeless homolog","TIM","TIMELESS"]
[1,1,"17.3848","16.8044",{"$nulls":4},"calcium ion binding",{"$nulls":4},1,1,1,"5.3","5.3","5.3","28.001","0.002095","2.2299",9455600,2,"3.48809","0.391543","-16.0946","-55.4546","tr|H0Y3T6|H0Y3T6_HUMAN;tr|G3V1E2|G3V1E2_HUMAN;sp|Q9BRK5|CAB45_HUMAN","tr|H0Y3T6|H0Y3T6_HUMAN;tr|G3V1E2|G3V1E2_HUMAN;sp|Q9BRK5|CAB45_HUMAN",2427,"H0Y3T6","H0Y3T6_HUMAN",null,null,"SDF4"]
[1,1,"16.8869","17.5382",{"$nulls":3},"cysteine biosynthetic process from serine",{"$nulls":5},1,1,1,"9.6","9.6","9.6","19.087",0,"3.7301",18501000,2,"3.39445","0.413263","-16.2126","-49.7846","tr|C9JMA6|C9JMA6_HUMAN;sp|P35520|CBS_HUMAN","tr|C9JMA6|C9JMA6_HUMAN;sp|P35520|CBS_HUMAN",931,"C9JMA6","C9JMA6_HUMAN",null,null,"CBS"]
[1,1,"17.2007","17.6566",{"$nulls":3},"cell proliferation;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;gene silencing by RNA;nuclear-transcribed mRNA poly(A) tail shortening;regulation of transcription, DNA-templated;regulation of translation;transcription, DNA-templated",null,"CCR4-NOT complex;cytosol;nucleus",{"$nulls":3},1,1,1,"2.4","2.4","2.4","55.215",0,"7.6588",28004000,9,"3.71583","0.406815","-16.4286","-72.086","sp|Q9UKZ1|CNO11_HUMAN","sp|Q9UKZ1|CNO11_HUMAN",2881,"Q9UKZ1","CNO11_HUMAN","CCR4-NOT transcription complex subunit 11",null,"CNOT11"]
[1,1,"18.2747","17.0006",{"$nulls":3},"intrinsic apoptotic signaling pathway in response to oxidative stress;positive regulation of apoptotic process;positive regulation of JNK cascade;positive regulation of kinase activity;positive regulation of MAPK cascade;ribosomal large subunit biogenesis","RNA binding;zinc ion binding","cytosol;cytosolic large ribosomal subunit;Golgi apparatus;nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},1,1,1,"3.1","3.1","3.1","54.271",0,"8.9247",18784000,1,"2.83481","0.536","-16.6377","-26.1172","sp|Q969S3|ZN622_HUMAN","sp|Q969S3|ZN622_HUMAN",2221,"Q969S3","ZN622_HUMAN","Zinc finger protein 622",null,"ZNF622"]
[1,1,"17.9601","17.3974",{"$nulls":3},"cilium assembly",null,"cilium",{"$nulls":3},1,1,1,"4.6","4.6","4.6","30.811",0,"3.5694",5131500,2,"3.54606","0.438667","-16.6787","-59.2839","sp|Q96LJ8|UBX10_HUMAN","sp|Q96LJ8|UBX10_HUMAN",2325,"Q96LJ8","UBX10_HUMAN","UBX domain-containing protein 10 {ECO:0000305}",null,"UBXN10"]
[1,1,"17.8423","17.5186",{"$nulls":3},"protein insertion into membrane",null,"integral component of membrane;mitochondrion",{"$nulls":3},1,1,1,"1.8","1.8","1.8","48.519","0.0078637","1.7343",15009000,3,"4.02627","0.352889","-16.6805","-103.063","tr|S4R3Q9|S4R3Q9_HUMAN;sp|Q15070|OXA1L_HUMAN;tr|J3KNA0|J3KNA0_HUMAN","tr|S4R3Q9|S4R3Q9_HUMAN;sp|Q15070|OXA1L_HUMAN;tr|J3KNA0|J3KNA0_HUMAN",1673,"S4R3Q9","S4R3Q9_HUMAN",null,null,"OXA1L"]
[1,1,"18.2455","17.1577",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"5.1","5.1","5.1","27.759","0.001114","2.7521",9282900,4,"2.97516","0.50464","-16.7016","-30.707","sp|Q9NW97|TMM51_HUMAN","sp|Q9NW97|TMM51_HUMAN",2726,"Q9NW97","TMM51_HUMAN","Transmembrane protein 51",null,"TMEM51"]
[1,1,"16.7122","19.0455",{"$nulls":3},"cell differentiation;covalent chromatin modification;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;multicellular organism development;regulation of transcription, DNA-templated;spermatogenesis;transcription, DNA-templated","histone binding","nuclear chromatin;nucleoplasm;protein complex",{"$nulls":3},2,2,2,"11.4","11.4","11.4","22.433",0,"3.5436",35696000,3,"2.32393","0.457268","-16.8788","-14.4683","sp|Q9NVP2|ASF1B_HUMAN;tr|K7ES22|K7ES22_HUMAN;tr|K7ELW9|K7ELW9_HUMAN;sp|Q9Y294|ASF1A_HUMAN","sp|Q9NVP2|ASF1B_HUMAN;tr|K7ES22|K7ES22_HUMAN;tr|K7ELW9|K7ELW9_HUMAN;sp|Q9Y294|ASF1A_HUMAN",2723,"Q9NVP2","ASF1B_HUMAN","Histone chaperone ASF1B",null,"ASF1B"]
[1,1,"20.0886","16.1209",{"$nulls":3},"cell cycle;cell division;DNA replication","DNA binding","nucleus",{"$nulls":3},2,2,2,"4.7","4.7","4.7","49.741","0.0010597","2.3301",35707000,2,"1.87986","0.390168","-17.1047","-8.62189","sp|Q6IQ49|SDE2_HUMAN","sp|Q6IQ49|SDE2_HUMAN",1871,"Q6IQ49","SDE2_HUMAN","Replication stress response regulator SDE2 {ECO:0000305}",null,"SDE2"]
[1,1,"18.4137","17.8677",{"$nulls":3},"apoptotic process;regulation of apoptotic process","cysteine-type endopeptidase activity",{"$nulls":4},1,1,1,"15.5","15.5","15.5","13.925",0,"6.0086",9150900,3,"3.59594","0.416276","-17.1407","-62.7892","tr|E7EQ01|E7EQ01_HUMAN;tr|E7EVN1|E7EVN1_HUMAN;tr|E7ETB7|E7ETB7_HUMAN;tr|E7EQ06|E7EQ06_HUMAN;tr|A0A0A0MS31|A0A0A0MS31_HUMAN;sp|Q14790|CASP8_HUMAN","tr|E7EQ01|E7EQ01_HUMAN;tr|E7EVN1|E7EVN1_HUMAN;tr|E7ETB7|E7ETB7_HUMAN;tr|E7EQ06|E7EQ06_HUMAN;tr|A0A0A0MS31|A0A0A0MS31_HUMAN;sp|Q14790|CASP8_HUMAN",1646,"E7EQ01","E7EQ01_HUMAN",null,null,"CASP8"]
[1,1,"18.0332","18.6309",{"$nulls":3},"cell cycle phase transition;cell division;DNA replication;DNA replication checkpoint;intra-S DNA damage checkpoint;positive regulation of cell proliferation;regulation of nuclear cell cycle DNA replication;replication fork arrest;replication fork protection;response to UV","DNA binding","cytoplasm;intracellular membrane-bounded organelle;nuclear chromatin;nucleoplasm;nucleus;replication fork protection complex",{"$nulls":3},1,1,1,"3.7","3.7","3.7","34.555",0,"9.2699",15669000,3,"3.52698","0.424516","-17.332","-57.9951","sp|Q9BVW5|TIPIN_HUMAN","sp|Q9BVW5|TIPIN_HUMAN",2475,"Q9BVW5","TIPIN_HUMAN","TIMELESS-interacting protein",null,"TIPIN"]
[1,1,"18.82","18.1612",{"$nulls":3},"abscission;cell separation after cytokinesis;endosomal transport;macroautophagy;mitotic cytokinesis checkpoint;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of cytokinesis;nucleus organization;positive regulation of viral release from host cell;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;regulation of viral process;ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;vacuolar transport;viral budding via host ESCRT complex;viral life cycle","protein homodimerization activity","cytosol;ESCRT III complex;extracellular exosome;Flemming body;late endosome membrane;midbody","Endocytosis;Necroptosis",null,null,1,1,1,6,6,6,"26.41","0.0003864","3.0672",23778000,1,"3.45048","0.421111","-17.4906","-53.1034","sp|Q96CF2|CHM4C_HUMAN","sp|Q96CF2|CHM4C_HUMAN",2246,"Q96CF2","CHM4C_HUMAN","Charged multivesicular body protein 4c",null,"CHMP4C"]
[1,1,"18.7359","18.5816",{"$nulls":3},"tRNA methylation","tRNA (cytosine) methyltransferase activity",{"$nulls":4},1,1,1,"3.4","3.4","3.4","43.426",0,"8.14",57316000,3,"4.7193","0.476","-17.6587","-228.898","sp|Q6P1Q9|MET2B_HUMAN","sp|Q6P1Q9|MET2B_HUMAN",1884,"Q6P1Q9","MET2B_HUMAN","Methyltransferase-like protein 2B",null,"METTL2B"]
[1,1,"19.5862","19.6095",{"$nulls":9},1,1,1,"12.6","12.6","12.6","9.5794","0.00038971","3.1361",7935100,5,"6.40798","0.544","-18.5979","-1599.51","tr|F8WDN6|F8WDN6_HUMAN;sp|Q9BXI6|TB10A_HUMAN","tr|F8WDN6|F8WDN6_HUMAN;sp|Q9BXI6|TB10A_HUMAN",2495,"F8WDN6","F8WDN6_HUMAN",null,null,"TBC1D10A"]
[1,1,"20.0413","19.2753",{"$nulls":3},"box C/D snoRNP assembly;maturation of LSU-rRNA;maturation of SSU-rRNA;mRNA splicing, via spliceosome;rRNA processing;single fertilization","ATPase binding;box C/D snoRNA binding;RNA binding;U3 snoRNA binding;U4 snRNA binding;U4atac snRNA binding","box C/D snoRNP complex;dense fibrillar component;nucleolus;nucleoplasm;nucleus;precatalytic spliceosome;protein complex;small-subunit processome;U4/U6 x U5 tri-snRNP complex","Ribosome biogenesis in eukaryotes;Spliceosome",null,null,1,1,1,"9.4","9.4","9.4","14.173","0.00076658","2.9824",42225000,2,"3.37567","0.416615","-18.6583","-48.7189","sp|P55769|NH2L1_HUMAN;tr|B1AHD1|B1AHD1_HUMAN","sp|P55769|NH2L1_HUMAN;tr|B1AHD1|B1AHD1_HUMAN",1211,"P55769","NH2L1_HUMAN","NHP2-like protein 1",null,"SNU13"]
[1,1,"20.2796","19.414",{"$nulls":3},"ATP biosynthetic process;ATP synthesis coupled proton transport;cristae formation;mitochondrial ATP synthesis coupled proton transport;oxidative phosphorylation;response to copper ion","ATPase activity;proton-transporting ATP synthase activity, rotational mechanism;transmembrane transporter activity;transporter activity","mitochondrial inner membrane;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,1,1,1,"8.3","8.3","8.3","17.49",0,"16.908",23208000,6,"3.2783","0.426419","-18.8468","-43.5488","sp|P30049|ATPD_HUMAN","sp|P30049|ATPD_HUMAN",860,"P30049","ATPD_HUMAN","ATP synthase subunit delta, mitochondrial",null,"ATP5D"]
[1,1,"20.0382","20.5161",{"$nulls":9},1,1,1,"13.6","13.6","13.6","8.6344",0,"17.257",30223000,9,"3.81363","0.34112","-19.2771","-80.6801","tr|H0YJ87|H0YJ87_HUMAN;tr|A0A087WTC9|A0A087WTC9_HUMAN;tr|G3V5I6|G3V5I6_HUMAN;tr|G3V256|G3V256_HUMAN;tr|H0YJA2|H0YJA2_HUMAN;sp|Q6PJT7|ZC3HE_HUMAN","tr|H0YJ87|H0YJ87_HUMAN;tr|A0A087WTC9|A0A087WTC9_HUMAN;tr|G3V5I6|G3V5I6_HUMAN;tr|G3V256|G3V256_HUMAN;tr|H0YJA2|H0YJA2_HUMAN;sp|Q6PJT7|ZC3HE_HUMAN",1896,"H0YJ87","H0YJ87_HUMAN",null,null,"ZC3H14"]
[1,1,"20.1686","21.0501",{"$nulls":9},1,1,1,"13.4","13.4","13.4","10.865",0,"25.762",47454000,7,"3.29695","0.425714","-19.6094","-44.495","tr|C9J7Y4|C9J7Y4_HUMAN;sp|Q8WWK9|CKAP2_HUMAN","tr|C9J7Y4|C9J7Y4_HUMAN;sp|Q8WWK9|CKAP2_HUMAN",2151,"C9J7Y4","C9J7Y4_HUMAN",null,null,"CKAP2"]
[1,1,"21.8406","21.6751",{"$nulls":4},"cysteine-type endopeptidase activity",{"$nulls":4},1,1,1,"9.4","9.4","9.4","13.366","0.0010661","2.3725",141150000,4,"4.79869","0.466286","-20.7578","-250.806","tr|C9JXR7|C9JXR7_HUMAN;tr|A0A087WU32|A0A087WU32_HUMAN;tr|A8MVM1|A8MVM1_HUMAN;sp|P42574|CASP3_HUMAN","tr|C9JXR7|C9JXR7_HUMAN;tr|A0A087WU32|A0A087WU32_HUMAN;tr|A8MVM1|A8MVM1_HUMAN;sp|P42574|CASP3_HUMAN",995,"C9JXR7","C9JXR7_HUMAN",null,null,"CASP3"]

{"sheet":"LS174T_Allproteins_3DsiKvssiC","index":4,"n_rows":4521,"n_cols":36,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["3D siKRAS 2 ","3D siKRAS 1","3D NT  2","3D NT 1","C: Only identified by site","C: Reverse","C: Potential contaminant","C: GOBP name","C: GOMF name","C: GOCC name","C: KEGG pathway name","C: Student's T-test Significant 3D siKRAS_2D siKRAS","C: Student's T-test significant","N: Peptides","N: Razor + unique peptides","N: Unique peptides","N: Sequence coverage [%]","N: Unique + razor sequence coverage [%]","N: Unique sequence coverage [%]","N: Mol. weight [kDa]","N: Q-value","N: Score","N: Intensity","N: MS/MS Count","N: -Log Student's T-test p-value 3D siKRAS_2D siKRAS","N: Student's T-test q-value 3D siKRAS_2D siKRAS","N: Student's T-test Difference 3D siKRAS_2D siKRAS","N: Student's T-test Test statistic 3D siKRAS_2D siKRAS","T: Protein IDs","T: Majority protein IDs","T: id","T: Uniprot IDs","T: Uniprot name","T: Uniprot full protein name","T: Uniprot short protein name","T: Gene name"]
["20.1228","19.9216",1,1,{"$nulls":3},"cellular defense response",{"$nulls":5},1,1,1,"30.2","30.2","30.2","12.763","0.008168","2.3581",11502000,3,"4.5534",1,"19.0222","189.099","sp|Q9UEU5|GGE2D_HUMAN;sp|Q6NT46|GAG2A_HUMAN;sp|Q4V326|GAG2E_HUMAN;sp|Q13066|GAG2B_HUMAN;tr|A0A087X111|A0A087X111_HUMAN","sp|Q9UEU5|GGE2D_HUMAN;sp|Q6NT46|GAG2A_HUMAN;sp|Q4V326|GAG2E_HUMAN;sp|Q13066|GAG2B_HUMAN;tr|A0A087X111|A0A087X111_HUMAN",2199,"Q9UEU5","GGE2D_HUMAN","G antigen 2D","AGE-2D","GAGE2D;GAGE8"]
["20.2477","19.4158",1,1,{"$nulls":3},"chromosome segregation;histone methylation;N-terminal peptidyl-alanine methylation;N-terminal peptidyl-alanine trimethylation;N-terminal peptidyl-glycine methylation;N-terminal peptidyl-proline dimethylation;N-terminal peptidyl-serine dimethylation;N-terminal peptidyl-serine trimethylation;spindle organization","histone methyltransferase activity;N-terminal protein N-methyltransferase activity;protein methyltransferase activity","cytoplasm;cytosol;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"11.2","11.2","11.2","25.387",0,"14.264",43686000,3,"3.312",1,"18.8318","45.2733","sp|Q9BV86|NTM1A_HUMAN;tr|S4R344|S4R344_HUMAN;tr|S4R3J7|S4R3J7_HUMAN","sp|Q9BV86|NTM1A_HUMAN;tr|S4R344|S4R344_HUMAN;tr|S4R3J7|S4R3J7_HUMAN",4003,"Q9BV86","NTM1A_HUMAN","N-terminal Xaa-Pro-Lys N-methyltransferase 1",null,"NTMT1"]
["18.998","19.5824",1,1,{"$nulls":4},"structural constituent of myelin sheath",{"$nulls":4},2,2,2,"38.4","38.4","38.4","17.442","0.002924","3.233",10702000,3,"3.59321",1,"18.2902","62.5927","tr|J3KS94|J3KS94_HUMAN;tr|J3QQK6|J3QQK6_HUMAN;sp|P02686|MBP_HUMAN","tr|J3KS94|J3KS94_HUMAN;tr|J3QQK6|J3QQK6_HUMAN;sp|P02686|MBP_HUMAN",822,"J3KS94","J3KS94_HUMAN",null,null,"MBP"]
["17.1793","18.2731",1,1,{"$nulls":3},"CDP-diacylglycerol biosynthetic process;phosphatidic acid biosynthetic process;phospholipid biosynthetic process","1-acylglycerol-3-phosphate O-acyltransferase activity","endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane;integral component of membrane;membrane;nuclear envelope;plasma membrane","Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phospholipase D signaling pathway",null,null,1,1,1,"2.7","2.7","2.7","43.38","0.0029264","3.2356",26286000,2,"2.97171",1,"16.7262","30.585","sp|Q9NRZ7|PLCC_HUMAN","sp|Q9NRZ7|PLCC_HUMAN",4433,"Q9NRZ7","PLCC_HUMAN","1-acyl-sn-glycerol-3-phosphate acyltransferase gamma",null,"AGPAT3"]
["17.3185","18.0756",1,1,{"$nulls":4},"hydrolase activity;metal ion binding","extracellular exosome",{"$nulls":3},2,2,2,"12.9","12.9","12.9","31.371","0.00024278","5.7365",19870000,4,"3.2894",1,"16.697","44.1093","sp|Q68D91|MBLC2_HUMAN","sp|Q68D91|MBLC2_HUMAN",2794,"Q68D91","MBLC2_HUMAN","Metallo-beta-lactamase domain-containing protein 2",null,"MBLAC2"]
["16.2506","17.8763",1,1,{"$nulls":3},"protein glycosylation","galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;metal ion binding","Golgi membrane",{"$nulls":3},6,6,6,"21.6","21.6","21.6","34.963",0,"17.818",264170000,15,"2.59328",1,"16.0634","19.7609","tr|G3V150|G3V150_HUMAN;sp|O94766|B3GA3_HUMAN;tr|E9PNA1|E9PNA1_HUMAN","tr|G3V150|G3V150_HUMAN;sp|O94766|B3GA3_HUMAN",650,"G3V150","G3V150_HUMAN","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase {ECO:0000256|RuleBase:RU363127}"]
["16.1279","17.2266",1,1,{"$nulls":3},"adult walking behavior;brain development;cell chemotaxis;chemical synaptic transmission, postsynaptic;desensitization of G-protein coupled receptor protein signaling pathway by arrestin;detection of temperature stimulus involved in sensory perception of pain;dopamine receptor signaling pathway;follicle-stimulating hormone signaling pathway;G-protein coupled receptor internalization;G-protein coupled receptor signaling pathway;membrane organization;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of GTPase activity;negative regulation of interleukin-1 beta production;negative regulation of interleukin-12 production;negative regulation of interleukin-6 production;negative regulation of natural killer cell mediated cytotoxicity;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein kinase B signaling;negative regulation of protein phosphorylation;negative regulation of protein ubiquitination;negative regulation of release of cytochrome c from mitochondria;negative regulation of smooth muscle cell apoptotic process;negative regulation of toll-like receptor signaling pathway;negative regulation of tumor necrosis factor production;platelet activation;positive regulation of calcium ion transport;positive regulation of cardiac muscle cell differentiation;positive regulation of DNA biosynthetic process;positive regulation of ERK1 and ERK2 cascade;positive regulation of gene expression;positive regulation of peptidyl-serine phosphorylation;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of protein kinase B signaling;positive regulation of protein ubiquitination;positive regulation of receptor internalization;positive regulation of synaptic transmission, dopaminergic;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein transport;protein ubiquitination;receptor internalization;regulation of androgen receptor signaling pathway;transcription from RNA polymerase II promoter;transforming growth factor beta receptor signaling pathway;Wnt signaling pathway, planar cell polarity pathway","14-3-3 protein binding;alpha-1A adrenergic receptor binding;alpha-1B adrenergic receptor binding;angiotensin receptor binding;arrestin family protein binding;D1 dopamine receptor binding;enzyme binding;follicle-stimulating hormone receptor binding;G-protein coupled receptor binding;identical protein binding;mitogen-activated protein kinase binding;platelet activating factor receptor binding;protein complex binding;protein complex scaffold activity;protein domain specific binding;protein kinase B binding;receptor binding;type 1 angiotensin receptor binding;type 2A serotonin receptor binding;ubiquitin protein ligase binding","basolateral plasma membrane;clathrin-coated pit;cytoplasm;cytoplasmic vesicle;cytosol;dendritic spine;endocytic vesicle;intracellular membrane-bounded organelle;nucleus;plasma membrane;postsynaptic density;postsynaptic membrane","Chemokine signaling pathway;Dopaminergic synapse;Endocytosis;Hedgehog signaling pathway;MAPK signaling pathway;Morphine addiction;Olfactory transduction;Parathyroid hormone synthesis, secretion and action;Relaxin signaling pathway",null,null,10,10,9,"25.4","25.4","23.7","46.105",0,"24.219",258990000,40,"2.91163",1,"15.6772","28.5375","sp|P32121|ARRB2_HUMAN;tr|Q68DZ5|Q68DZ5_HUMAN;tr|K7ENA6|K7ENA6_HUMAN;tr|I3L412|I3L412_HUMAN;tr|K7EL17|K7EL17_HUMAN;tr|I3L0V6|I3L0V6_HUMAN","sp|P32121|ARRB2_HUMAN;tr|Q68DZ5|Q68DZ5_HUMAN;tr|K7ENA6|K7ENA6_HUMAN",1346,"P32121","ARRB2_HUMAN","Beta-arrestin-2",null,"ARRB2"]
["17.2717","14.7765",1,1,{"$nulls":4},"ATP binding",{"$nulls":4},2,2,2,"2.7","2.7","2.7","117.85","0.0065347","2.5632",10991000,2,"2.16592",1,"15.0241","12.0428","tr|A0A0G2JMG8|A0A0G2JMG8_HUMAN;tr|A0A0G2JLX3|A0A0G2JLX3_HUMAN;tr|J3KN39|J3KN39_HUMAN;tr|A0A0G2JPQ2|A0A0G2JPQ2_HUMAN;sp|Q9NX02|NALP2_HUMAN;tr|K7EMK2|K7EMK2_HUMAN;tr|A0A0G2JPB6|A0A0G2JPB6_HUMAN;tr|A0A0G2JLQ8|A0A0G2JLQ8_HUMAN;tr|A0A0G2JP37|A0A0G2JP37_HUMAN;tr|A0A0G2JNC8|A0A0G2JNC8_HUMAN","tr|A0A0G2JMG8|A0A0G2JMG8_HUMAN;tr|A0A0G2JLX3|A0A0G2JLX3_HUMAN;tr|J3KN39|J3KN39_HUMAN;tr|A0A0G2JPQ2|A0A0G2JPQ2_HUMAN;sp|Q9NX02|NALP2_HUMAN;tr|K7EMK2|K7EMK2_HUMAN;tr|A0A0G2JPB6|A0A0G2JPB6_HUMAN;tr|A0A0G2JLQ8|A0A0G2JLQ8_HUMAN;tr|A0A0G2JP37|A0A0G2JP37_HUMAN;tr|A0A0G2JNC8|A0A0G2JNC8_HUMAN",4528,"A0A0G2JMG8","A0A0G2JMG8_HUMAN",null,null,"NLRP2"]
["15.8213","16.0145",1,1,{"$nulls":3},"apoptotic process;intracellular signal transduction;regulation of JNK cascade;viral process","ATP binding;guanylate kinase activity;protein complex scaffold activity","bicellular tight junction;cell junction;membrane;nucleus;plasma membrane","Rap1 signaling pathway",null,null,4,4,4,4,4,4,"165.61","0.00024349","5.7752",29209000,5,"4.37707",1,"14.9179","154.356","sp|Q5TCQ9|MAGI3_HUMAN","sp|Q5TCQ9|MAGI3_HUMAN",2741,"Q5TCQ9","MAGI3_HUMAN","Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3",null,"MAGI3"]
["15.0591","16.407",1,1,{"$nulls":3},"cellular glucuronidation;flavonoid glucuronidation;metabolic process;negative regulation of cellular glucuronidation;negative regulation of fatty acid metabolic process;negative regulation of glucuronosyltransferase activity;retinoic acid metabolic process;xenobiotic glucuronidation","enzyme binding;glucuronosyltransferase activity;protein heterodimerization activity;protein homodimerization activity;retinoic acid binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Ascorbate and aldarate metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pentose and glucuronate interconversions;Porphyrin and chlorophyll metabolism;Retinol metabolism;Steroid hormone biosynthesis",null,null,8,2,2,"24.7","4.7","4.7","60.338","0.00023935","5.4263",35396000,4,"2.68071",1,"14.733","21.8613","sp|P35503|UD13_HUMAN","sp|P35503|UD13_HUMAN",1385,"P35503","UD13_HUMAN","UDP-glucuronosyltransferase 1-3","DPGT 1-3;GT1*3;GT1.3;GT1-03","UGT1A3"]
["19.9499","11.0313",1,1,{"$nulls":3},"rRNA processing;tRNA export from nucleus","RNA binding","condensed nuclear chromosome;CURI complex;mitochondrion;nucleolus;nucleoplasm;nucleus;small-subunit processome;UTP-C complex","Ribosome biogenesis in eukaryotes",null,null,11,11,11,12,12,12,"127.59",0,"31.88",368160000,45,"1.08054",1,"14.4906","3.24951","sp|Q9H6R4|NOL6_HUMAN;tr|A0A0A0MRW6|A0A0A0MRW6_HUMAN;tr|A0A0C4DFX0|A0A0C4DFX0_HUMAN","sp|Q9H6R4|NOL6_HUMAN;tr|A0A0A0MRW6|A0A0A0MRW6_HUMAN",4229,"Q9H6R4","NOL6_HUMAN","Nucleolar protein 6",null,"NOL6"]
["15.0855","15.8462",1,1,{"$nulls":3},"endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","RNA binding","90S preribosome;nucleolus",{"$nulls":3},8,8,8,"17.5","17.5","17.5","82.597",0,"56.327",167870000,40,"3.16071",1,"14.4658","38.0304","sp|Q8N9T8|KRI1_HUMAN;tr|H0YFD2|H0YFD2_HUMAN;tr|F8WFC1|F8WFC1_HUMAN;tr|H0YH26|H0YH26_HUMAN","sp|Q8N9T8|KRI1_HUMAN",3271,"Q8N9T8","KRI1_HUMAN","Protein KRI1 homolog",null,"KRI1"]
["15.099","15.3616",1,1,{"$nulls":3},"cytoskeleton-dependent intracellular transport;microtubule-based movement;retrograde vesicle-mediated transport, Golgi to ER","ATP binding;ATPase activity;microtubule binding;microtubule motor activity;motor activity;RNA binding","endoplasmic reticulum;Golgi apparatus;kinesin complex;microtubule",{"$nulls":3},4,2,2,"5.7","3.4","3.4","122.95","0.0054119","2.6697",12388000,3,"4.06988",1,"14.2303","108.371","sp|O43896|KIF1C_HUMAN","sp|O43896|KIF1C_HUMAN",449,"O43896","KIF1C_HUMAN","Kinesin-like protein KIF1C",null,"KIF1C"]
["15.1149","15.3291",1,1,{"$nulls":3},"cellular response to UV;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of protein ubiquitination",null,"nucleolus;PML body",{"$nulls":3},1,1,1,"1.8","1.8","1.8","100.38","0.0036991","2.9842",11271000,3,"4.24663",1,"14.222","132.83","sp|O75113|N4BP1_HUMAN","sp|O75113|N4BP1_HUMAN",522,"O75113","N4BP1_HUMAN","NEDD4-binding protein 1","4BP1","N4BP1"]
["14.6389","15.2473",1,1,{"$nulls":4},"metal ion binding;metalloendopeptidase activity",{"$nulls":4},4,4,4,"4.7","4.7","4.7","125.12","0.0037159","3.0757",13161000,3,"3.32283",1,"13.9431","45.8417","tr|G3V1R5|G3V1R5_HUMAN;sp|O43847|NRDC_HUMAN;tr|B1AKJ5|B1AKJ5_HUMAN;tr|H0Y5G9|H0Y5G9_HUMAN;tr|A0A087WYK8|A0A087WYK8_HUMAN;tr|F5H7V1|F5H7V1_HUMAN","tr|G3V1R5|G3V1R5_HUMAN;sp|O43847|NRDC_HUMAN;tr|B1AKJ5|B1AKJ5_HUMAN;tr|H0Y5G9|H0Y5G9_HUMAN;tr|A0A087WYK8|A0A087WYK8_HUMAN;tr|F5H7V1|F5H7V1_HUMAN",446,"G3V1R5","G3V1R5_HUMAN",null,null,"NRDC"]
["13.5111","15.7033",1,1,{"$nulls":4},"nucleic acid binding","cytosol;nucleoplasm;plasma membrane",{"$nulls":3},5,5,5,"5.8","5.8","5.8","145.44",0,"10.9",51204000,11,"2.19205",1,"13.6072","12.4144","tr|S4R3H4|S4R3H4_HUMAN;tr|E7EQT4|E7EQT4_HUMAN;sp|Q9UKV3|ACINU_HUMAN;tr|G3V3B0|G3V3B0_HUMAN;tr|G3V3T3|G3V3T3_HUMAN","tr|S4R3H4|S4R3H4_HUMAN;tr|E7EQT4|E7EQT4_HUMAN;sp|Q9UKV3|ACINU_HUMAN;tr|G3V3B0|G3V3B0_HUMAN",5306,"S4R3H4","S4R3H4_HUMAN",null,null,"ACIN1"]
["12.6145","14.162",1,1,{"$nulls":3},"activation of protein kinase activity;cell division;cell proliferation in forebrain;cerebellar cortex development;cerebellar granular layer structural organization;cerebellar Purkinje cell layer structural organization;cerebral cortex development;establishment of protein localization;hippocampus development;microtubule-based movement;mitotic metaphase plate congression;negative regulation of apoptotic process;negative regulation of integrin activation;negative regulation of neuron apoptotic process;olfactory bulb development;positive regulation of cell proliferation;positive regulation of cytokinesis;proteasome-mediated ubiquitin-dependent protein catabolic process;regulation of cell adhesion;regulation of cell growth;regulation of cell maturation;regulation of cell migration;regulation of G1/S transition of mitotic cell cycle;regulation of G2/M transition of mitotic cell cycle;regulation of myelination;regulation of neuron apoptotic process;regulation of Rap protein signal transduction;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;substrate adhesion-dependent cell spreading","ATP binding;ATPase activity;ATP-dependent microtubule motor activity, plus-end-directed;microtubule binding;microtubule motor activity;PDZ domain binding;protein kinase binding;tubulin binding","cytosol;kinesin complex;membrane;microtubule;midbody;nucleus;spindle midzone",{"$nulls":3},6,6,6,"4.7","4.7","4.7","186.49",0,"9.0421",45599000,10,"2.41138",1,"12.3883","16.0112","sp|Q15058|KIF14_HUMAN","sp|Q15058|KIF14_HUMAN",2443,"Q15058","KIF14_HUMAN","Kinesin-like protein KIF14 {ECO:0000305}",null,"KIF14"]
["24.7954","23.6549","24.5497",1,{"$nulls":9},1,1,1,"68.3","68.3","68.3","3.9694","0.00025259","6.5686",217990000,0,"0.362652",1,"11.4503","0.971293","tr|K7ENI6|K7ENI6_HUMAN;tr|K7ERE1|K7ERE1_HUMAN;sp|Q8N2U0|TM256_HUMAN","tr|K7ENI6|K7ENI6_HUMAN;tr|K7ERE1|K7ERE1_HUMAN;sp|Q8N2U0|TM256_HUMAN",3209,"K7ENI6","K7ENI6_HUMAN",null,null,"TMEM256-PLSCR3"]
["22.0066","23.3264","22.3504",1,{"$nulls":3},"angiogenesis;erythrocyte differentiation;generation of precursor metabolites and energy;heme biosynthetic process;mitochondrial depolarization;negative regulation of ATPase activity;negative regulation of endothelial cell proliferation;negative regulation of hydrolase activity;positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of proteolysis involved in cellular protein catabolic process;protein homooligomerization;protein homotetramerization;reactive oxygen species metabolic process;regulation of ATP metabolic process;regulation of protein targeting to mitochondrion","angiostatin binding;ATPase binding;ATPase inhibitor activity;calmodulin binding;enzyme binding;enzyme inhibitor activity;protein homodimerization activity","cell surface;mitochondrion",{"$nulls":3},2,2,2,16,16,16,"12.249","0.00024272","5.723",322040000,11,"0.384939",1,"10.9913","1.02765","sp|Q9UII2|ATIF1_HUMAN;tr|A0A0B4J230|A0A0B4J230_HUMAN","sp|Q9UII2|ATIF1_HUMAN;tr|A0A0B4J230|A0A0B4J230_HUMAN",4756,"Q9UII2","ATIF1_HUMAN","ATPase inhibitor, mitochondrial",null,"ATPIF1"]
["20.5771","22.2734","20.8426",1,{"$nulls":9},1,1,1,22,22,22,"5.8668","0.00066593","4.0733",39983000,3,"0.395666",1,"10.5039","1.05488","tr|F8VSA6|F8VSA6_HUMAN;tr|E9PS38|E9PS38_HUMAN;sp|Q15843|NEDD8_HUMAN;tr|S4R3E9|S4R3E9_HUMAN;tr|E9PL57|E9PL57_HUMAN","tr|F8VSA6|F8VSA6_HUMAN;tr|E9PS38|E9PS38_HUMAN;sp|Q15843|NEDD8_HUMAN;tr|S4R3E9|S4R3E9_HUMAN;tr|E9PL57|E9PL57_HUMAN",2530,"F8VSA6","F8VSA6_HUMAN",null,null,"NEDD8"]
["19.5133","22.5961",1,"20.2599",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"24.4","24.4","24.4","18.349","0.0052272","2.7087",114200000,5,"0.401185",1,"10.4247","1.06892","tr|H0YKJ9|H0YKJ9_HUMAN;sp|O60637|TSN3_HUMAN","tr|H0YKJ9|H0YKJ9_HUMAN;sp|O60637|TSN3_HUMAN",488,"H0YKJ9","H0YKJ9_HUMAN",null,null,"TSPAN3"]
["21.1005","22.0685","21.331",1,{"$nulls":9},2,2,2,"30.5","30.5","30.5","11.956",0,"27.479",97887000,9,"0.383414",1,"10.419","1.02378","tr|H3BNF1|H3BNF1_HUMAN;tr|H3BUV4|H3BUV4_HUMAN;tr|H3BUT1|H3BUT1_HUMAN;sp|Q9NWW5|CLN6_HUMAN;tr|H3BRN7|H3BRN7_HUMAN;tr|H3BTY4|H3BTY4_HUMAN","tr|H3BNF1|H3BNF1_HUMAN;tr|H3BUV4|H3BUV4_HUMAN;tr|H3BUT1|H3BUT1_HUMAN;sp|Q9NWW5|CLN6_HUMAN;tr|H3BRN7|H3BRN7_HUMAN;tr|H3BTY4|H3BTY4_HUMAN",4524,"H3BNF1","H3BNF1_HUMAN",null,null,"CLN6"]
["21.6407","21.5551",1,"21.3755",{"$nulls":3},"histone H3-K27 trimethylation;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;nucleosome assembly;nucleosome positioning","ADP binding;AMP binding;ATP binding;calcium ion binding;chromatin DNA binding;dATP binding;double-stranded DNA binding;GTP binding;RNA binding","extracellular exosome;nuclear heterochromatin;nuclear nucleosome;nucleus",{"$nulls":3},7,1,1,"27.4","7.3","7.3","21.865",0,"9.9946",3478500000,21,"0.382638",1,"10.4101","1.02181","sp|P10412|H14_HUMAN","sp|P10412|H14_HUMAN",968,"P10412","H14_HUMAN","Histone H1.4",null,"HIST1H1E"]
["21.486","21.8002","21.5613",1,{"$nulls":9},1,1,1,"51.9","51.9","51.9","6.268","0.0080172","2.4226",72238000,0,"0.377118",1,"10.3625","1.00784","tr|E5RHZ4|E5RHZ4_HUMAN;tr|H0YBJ0|H0YBJ0_HUMAN;sp|P06746|DPOLB_HUMAN","tr|E5RHZ4|E5RHZ4_HUMAN;tr|H0YBJ0|H0YBJ0_HUMAN;sp|P06746|DPOLB_HUMAN",882,"E5RHZ4","E5RHZ4_HUMAN",null,null,"POLB"]
["20.0588","21.7203","20.079",1,{"$nulls":3},"cell volume homeostasis;chloride transport;spliceosomal snRNP assembly",null,"cytosol;methylosome;nucleoplasm;nucleus;pICln-Sm protein complex;plasma membrane",{"$nulls":3},3,3,3,"33.5","33.5","33.5","18.259","0.00025846","7.0969",60049000,6,"0.405877",1,"10.35","1.08087","tr|E9PMI6|E9PMI6_HUMAN;tr|J3KN38|J3KN38_HUMAN;sp|P54105|ICLN_HUMAN;tr|E9PJF4|E9PJF4_HUMAN;tr|E9PQ83|E9PQ83_HUMAN","tr|E9PMI6|E9PMI6_HUMAN;tr|J3KN38|J3KN38_HUMAN;sp|P54105|ICLN_HUMAN;tr|E9PJF4|E9PJF4_HUMAN",1731,"E9PMI6","E9PMI6_HUMAN",null,null,"CLNS1A"]
["23.042","21.8241","23.3448",1,{"$nulls":3},"oocyte maturation;spindle assembly involved in female meiosis","GTP binding;GTPase activity;structural constituent of cytoskeleton","cytoplasm;extracellular exosome;meiotic spindle;microtubule;microtubule cytoskeleton","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,9,1,1,"24.3","7.2","7.2","49.775",0,"141.21",798390000,10,"0.341101",1,"10.2607","0.917034","sp|Q3ZCM7|TBB8_HUMAN;tr|A0A075B736|A0A075B736_HUMAN;tr|Q5SQY0|Q5SQY0_HUMAN","sp|Q3ZCM7|TBB8_HUMAN;tr|A0A075B736|A0A075B736_HUMAN;tr|Q5SQY0|Q5SQY0_HUMAN",2621,"Q3ZCM7","TBB8_HUMAN","Tubulin beta-8 chain {ECO:0000305}",null,"TUBB8"]
["19.0007","21.4129","19.1178",1,{"$nulls":9},2,2,2,"13.9","13.9","13.9","25.766",0,"11.015",56071000,5,"0.417439",1,"10.1479","1.11041","tr|F8WDP1|F8WDP1_HUMAN;tr|A0A0A0MRY0|A0A0A0MRY0_HUMAN;sp|Q8WUA7|TB22A_HUMAN","tr|F8WDP1|F8WDP1_HUMAN;tr|A0A0A0MRY0|A0A0A0MRY0_HUMAN;sp|Q8WUA7|TB22A_HUMAN",3417,"F8WDP1","F8WDP1_HUMAN",null,null,"TBC1D22A"]
["14.7762","21.8909","15.4505",1,{"$nulls":4},"protein tyrosine phosphatase activity","cell junction;integral component of membrane;intracellular membrane-bounded organelle;plasma membrane",{"$nulls":3},5,5,5,"5.5","5.5","5.5","164.2",0,"12.201",4352200000,12,"0.47339",1,"10.1083","1.25514","tr|Q5TG12|Q5TG12_HUMAN;tr|E9PGC5|E9PGC5_HUMAN;sp|Q15262|PTPRK_HUMAN;tr|H0YDP9|H0YDP9_HUMAN;tr|H0Y6P5|H0Y6P5_HUMAN","tr|Q5TG12|Q5TG12_HUMAN;tr|E9PGC5|E9PGC5_HUMAN;sp|Q15262|PTPRK_HUMAN",5212,"Q5TG12","Q5TG12_HUMAN",null,null,"PTPRK"]
["19.187","18.9837","17.0091",1,{"$nulls":5},"mitochondrion;nucleoplasm",{"$nulls":3},3,3,3,"41.2","41.2","41.2","11.716",0,"11.384",103720000,12,"0.474975",1,"10.0808","1.25929","tr|A0A087WZX2|A0A087WZX2_HUMAN;sp|O95139|NDUB6_HUMAN","tr|A0A087WZX2|A0A087WZX2_HUMAN;sp|O95139|NDUB6_HUMAN",691,"A0A087WZX2","A0A087WZX2_HUMAN",null,null,"NDUFB6"]
["21.3662","22.0785","22.3143",1,{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;apoptotic process;ciliary basal body-plasma membrane docking;cilium assembly;ER to Golgi vesicle-mediated transport;G2/M transition of mitotic cell cycle;intraciliary retrograde transport;intraciliary transport involved in cilium assembly;macroautophagy;motile cilium assembly;negative regulation of phosphorylation;neutrophil degranulation;positive regulation of ATP-dependent microtubule motor activity, plus-end-directed;positive regulation of insulin secretion involved in cellular response to glucose stimulus;positive regulation of non-motile cilium assembly;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;regulation of G2/M transition of mitotic cell cycle;regulation of transcription, DNA-templated;sister chromatid cohesion;spermatid development;substantia nigra development;transcription, DNA-templated;transport along microtubule;viral process","cytoskeletal protein binding;dynein intermediate chain binding;dynein light intermediate chain binding;enzyme binding;motor activity;nitric-oxide synthase regulator activity;protein C-terminus binding;protein domain specific binding;protein heterodimerization activity;protein homodimerization activity;scaffold protein binding","axon cytoplasm;centrosome;ciliary tip;cilium;cytoplasm;cytoplasmic dynein complex;cytosol;extracellular exosome;ficolin-1-rich granule membrane;kinetochore;membrane;microtubule;mitochondrion;mitotic spindle;nucleus;plasma membrane;tertiary granule membrane","Vasopressin-regulated water reabsorption",null,null,3,2,2,"44.9","32.6","32.6","10.366",0,"8.3347",162870000,17,"0.351791",1,"10.0652","0.943926","sp|P63167|DYL1_HUMAN;tr|F8VXL2|F8VXL2_HUMAN;tr|F8VRV5|F8VRV5_HUMAN;tr|F8VXI7|F8VXI7_HUMAN","sp|P63167|DYL1_HUMAN;tr|F8VXL2|F8VXL2_HUMAN;tr|F8VRV5|F8VRV5_HUMAN",1940,"P63167","DYL1_HUMAN","Dynein light chain 1, cytoplasmic",null,"DYNLL1"]
["19.3778","20.6377","18.9171",1,{"$nulls":9},4,4,4,"31.7","31.7","31.7","22.554",0,"18.266",402050000,30,"0.420782",1,"10.0492","1.11897","tr|D6RBD8|D6RBD8_HUMAN;sp|Q8NBA8|DTWD2_HUMAN;tr|D6REE2|D6REE2_HUMAN;tr|J3KND6|J3KND6_HUMAN","tr|D6RBD8|D6RBD8_HUMAN;sp|Q8NBA8|DTWD2_HUMAN;tr|D6REE2|D6REE2_HUMAN",3279,"D6RBD8","D6RBD8_HUMAN",null,null,"DTWD2"]
["22.468","19.644","21.0327",1,{"$nulls":3},"lipid transport;nervous system development;protein homotrimerization;regulation of neuron apoptotic process","drug binding;identical protein binding;opioid receptor activity","cell junction;cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum membrane;growth cone;integral component of membrane;integral component of plasma membrane;lipid droplet;nuclear envelope;nuclear inner membrane;nuclear outer membrane;postsynaptic density;postsynaptic membrane",{"$nulls":3},3,3,3,"24.2","24.2","24.2","25.127",0,"11.95",100020000,8,"0.371058",1,"10.0397","0.992514","sp|Q99720|SGMR1_HUMAN;tr|Q5T1J1|Q5T1J1_HUMAN","sp|Q99720|SGMR1_HUMAN",3877,"Q99720","SGMR1_HUMAN","Sigma non-opioid intracellular receptor 1",null,"SIGMAR1"]
["21.4492","21.5894","22.0598",1,{"$nulls":3},"response to retinoic acid","hydrolase activity","cytoplasm;nucleus",{"$nulls":3},3,3,3,26,26,26,"24.418",0,"10.004",173270000,9,"0.353667",1,"9.9894","0.948648","sp|Q8WZ82|OVCA2_HUMAN","sp|Q8WZ82|OVCA2_HUMAN",3474,"Q8WZ82","OVCA2_HUMAN","Esterase OVCA2",null,"OVCA2"]
["21.5005","21.7013","22.23",1,{"$nulls":9},2,2,2,"42.6","42.6","42.6","5.3351","0.00026171","7.3102",85051000,7,"0.350507",1,"9.98591","0.940694","tr|K7ENF0|K7ENF0_HUMAN","tr|K7ENF0|K7ENF0_HUMAN",5283,"K7ENF0","K7ENF0_HUMAN",null,null,"NARS"]
["19.4134","20.5657","19.1855",1,{"$nulls":3},"apoptotic process;cellular response to tumor necrosis factor;negative regulation of apoptotic process;protein targeting to peroxisome;regulation of I-kappaB kinase/NF-kappaB signaling","DNA binding;polyubiquitin modification-dependent protein binding;zinc ion binding","cytoplasm",{"$nulls":3},2,2,2,"16.3","16.3","16.3","22.555","0.00026205","7.3526",39798000,9,"0.407986",1,"9.89683","1.08625","sp|Q6FIF0|ZFAN6_HUMAN;tr|H0YMR5|H0YMR5_HUMAN;tr|H0YLR2|H0YLR2_HUMAN;tr|H0YME2|H0YME2_HUMAN;tr|H0YK21|H0YK21_HUMAN;tr|H0YK54|H0YK54_HUMAN","sp|Q6FIF0|ZFAN6_HUMAN;tr|H0YMR5|H0YMR5_HUMAN;tr|H0YLR2|H0YLR2_HUMAN;tr|H0YME2|H0YME2_HUMAN;tr|H0YK21|H0YK21_HUMAN;tr|H0YK54|H0YK54_HUMAN",2810,"Q6FIF0","ZFAN6_HUMAN","AN1-type zinc finger protein 6",null,"ZFAND6"]
["18.743","18.9345","16.8861",1,{"$nulls":3},"glycosaminoglycan biosynthetic process","heparan sulfate 2-O-sulfotransferase activity","Golgi membrane;integral component of membrane;membrane","Glycosaminoglycan biosynthesis - heparan sulfate / heparin",null,null,8,8,8,"26.4","26.4","26.4","41.881",0,"52.888",2070100000,50,"0.469796",1,"9.89569","1.24574","sp|Q7LGA3|HS2ST_HUMAN;tr|K7EP71|K7EP71_HUMAN","sp|Q7LGA3|HS2ST_HUMAN",2980,"Q7LGA3","HS2ST_HUMAN","Heparan sulfate 2-O-sulfotransferase 1","OST;-O-sulfotransferase","HS2ST1"]
["21.439","20.6972","21.4238",1,{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;ribosomal small subunit assembly;translation","mRNA binding;RNA binding;rRNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit","Ribosome",null,null,10,10,10,"39.7","39.7","39.7","28.134",0,"34.041",472760000,49,"0.35997",1,"9.85619","0.96453","sp|Q9Y2R9|RT07_HUMAN;tr|J3QLS3|J3QLS3_HUMAN;tr|J3QQS1|J3QQS1_HUMAN;tr|J3QKW2|J3QKW2_HUMAN;tr|J3KSI8|J3KSI8_HUMAN","sp|Q9Y2R9|RT07_HUMAN;tr|J3QLS3|J3QLS3_HUMAN;tr|J3QQS1|J3QQS1_HUMAN;tr|J3QKW2|J3QKW2_HUMAN;tr|J3KSI8|J3KSI8_HUMAN",4931,"Q9Y2R9","RT07_HUMAN","28S ribosomal protein S7, mitochondrial","7mt;RP-S7","MRPS7"]
["19.6745","20.8919","19.9214",1,{"$nulls":9},1,1,1,"20.8","20.8","20.8","6.0239","0.0074554","2.4669",36635000,0,"0.388271",1,"9.82246","1.0361","tr|H3BUD2|H3BUD2_HUMAN;tr|H3BS05|H3BS05_HUMAN;tr|H3BR94|H3BR94_HUMAN;sp|Q9BTE1|DCTN5_HUMAN","tr|H3BUD2|H3BUD2_HUMAN;tr|H3BS05|H3BS05_HUMAN;tr|H3BR94|H3BR94_HUMAN;sp|Q9BTE1|DCTN5_HUMAN",3965,"H3BUD2","H3BUD2_HUMAN",null,null,"DCTN5"]
["20.2786","21.1933","20.887",1,{"$nulls":3},"proteasome-mediated ubiquitin-dependent protein catabolic process;protein K11-linked ubiquitination;protein K48-linked ubiquitination;protein ubiquitination;ubiquitin-dependent protein catabolic process","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;cytosol","Ubiquitin mediated proteolysis",null,null,4,4,4,"25.7","25.7","25.7","20.655",0,"14.621",84361000,11,"0.367593",1,"9.7924","0.983763","sp|P62256|UBE2H_HUMAN;tr|C9JZG9|C9JZG9_HUMAN;tr|C9JZY6|C9JZY6_HUMAN;tr|H7C4M9|H7C4M9_HUMAN;tr|C9J8Q9|C9J8Q9_HUMAN","sp|P62256|UBE2H_HUMAN;tr|C9JZG9|C9JZG9_HUMAN;tr|C9JZY6|C9JZY6_HUMAN;tr|H7C4M9|H7C4M9_HUMAN;tr|C9J8Q9|C9J8Q9_HUMAN",1879,"P62256","UBE2H_HUMAN","Ubiquitin-conjugating enzyme E2 H",null,"UBE2H"]
["19.9811","20.8498","20.273",1,{"$nulls":5},"cytosol;nucleus",{"$nulls":3},1,1,1,"23.3","23.3","23.3","11.852","0.0046929","2.8889",26455000,2,"0.379455",1,"9.77894","1.01375","tr|A0A087WTY9|A0A087WTY9_HUMAN;sp|Q9Y605|MOFA1_HUMAN","tr|A0A087WTY9|A0A087WTY9_HUMAN;sp|Q9Y605|MOFA1_HUMAN",5068,"A0A087WTY9","A0A087WTY9_HUMAN",null,null,"MRFAP1"]
["20.3848","20.5212","20.4149",1,{"$nulls":4},"translation elongation factor activity",{"$nulls":4},2,2,2,"30.1","30.1","30.1","12.527","0.00023901","5.4016",64134000,8,"0.375561",1,"9.74555","1.0039","tr|B8ZZU8|B8ZZU8_HUMAN;sp|Q15370|ELOB_HUMAN;tr|I3L0M9|I3L0M9_HUMAN;tr|A0A0B4J296|A0A0B4J296_HUMAN","tr|B8ZZU8|B8ZZU8_HUMAN;sp|Q15370|ELOB_HUMAN;tr|I3L0M9|I3L0M9_HUMAN;tr|A0A0B4J296|A0A0B4J296_HUMAN",2478,"B8ZZU8","B8ZZU8_HUMAN",null,null,"ELOB"]
["18.7849","19.6794",1,"17.9797",{"$nulls":4},"nucleic acid binding",{"$nulls":4},2,2,2,"14.4","14.4","14.4","24.13",0,"24.509",28744000,2,"0.431283",1,"9.74231","1.14593","tr|H0YAV9|H0YAV9_HUMAN;sp|Q9UIV1|CNOT7_HUMAN;tr|H0YBT3|H0YBT3_HUMAN;tr|E5RGH2|E5RGH2_HUMAN","tr|H0YAV9|H0YAV9_HUMAN;sp|Q9UIV1|CNOT7_HUMAN;tr|H0YBT3|H0YBT3_HUMAN;tr|E5RGH2|E5RGH2_HUMAN",4759,"H0YAV9","H0YAV9_HUMAN",null,null,"CNOT7"]
["21.2617","20.4716","21.399",1,{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of viral genome replication;protein complex assembly;protein folding","cyclosporin A binding;peptidyl-prolyl cis-trans isomerase activity;ribonucleoprotein complex binding","cytoplasm;nuclear speck;nucleoplasm;spliceosomal complex;U4/U6 snRNP;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,5,5,5,"46.9","46.9","46.9","19.208",0,"18.138",310360000,16,"0.353049",1,"9.66713","0.947094","sp|O43447|PPIH_HUMAN;tr|C9JQD4|C9JQD4_HUMAN;tr|H0YEL5|H0YEL5_HUMAN;tr|C9JAN8|C9JAN8_HUMAN","sp|O43447|PPIH_HUMAN;tr|C9JQD4|C9JQD4_HUMAN;tr|H0YEL5|H0YEL5_HUMAN",401,"O43447","PPIH_HUMAN","Peptidyl-prolyl cis-trans isomerase H","PIase H","PPIH"]
["18.0771","17.9154","15.6861",1,{"$nulls":3},"mitochondrial tRNA methylation","tRNA (guanine(37)-N(1))-methyltransferase activity","mitochondrial matrix;nucleus",{"$nulls":3},3,3,3,"8.1","8.1","8.1","58.246",0,"11.098",41649000,8,"0.49596",1,"9.65315","1.31451","sp|Q32P41|TRM5_HUMAN","sp|Q32P41|TRM5_HUMAN",2610,"Q32P41","TRM5_HUMAN","tRNA (guanine(37)-N1)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03152}",null,"TRMT5"]
["18.6189","19.6549","17.9765",1,{"$nulls":3},"7-methylguanosine mRNA capping;apoptotic process;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, exonucleolytic;positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of translational initiation;positive regulation of viral transcription;regulation of gene silencing by miRNA;RNA metabolic process;snRNA transcription from RNA polymerase II promoter;somatic stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;transcription, DNA-templated;transcription-coupled nucleotide-excision repair","DNA-directed 5'-3' RNA polymerase activity;single-stranded DNA binding;single-stranded RNA binding;translation initiation factor binding","DNA-directed RNA polymerase II, core complex;nucleoplasm;nucleus;P-body","Huntington disease;RNA polymerase",null,null,4,4,4,"29.7","29.7","29.7","19.294",0,"7.9867",76069000,9,"0.426872",1,"9.64866","1.1346","sp|P62487|RPB7_HUMAN;tr|E9PIU7|E9PIU7_HUMAN;tr|H0YEE4|H0YEE4_HUMAN;tr|E9PKH3|E9PKH3_HUMAN","sp|P62487|RPB7_HUMAN",1899,"P62487","RPB7_HUMAN","DNA-directed RNA polymerase II subunit RPB7","NA polymerase II subunit B7","POLR2G"]
["19.9769","20.6356","20.3276",1,{"$nulls":3},"proton-transporting ATP synthase complex assembly",null,"cytosol;mitochondrion;nuclear speck",{"$nulls":3},4,4,4,"19.7","19.7","19.7","32.772",0,"12.963",117550000,4,"0.372914",1,"9.6424","0.997206","sp|Q8N5M1|ATPF2_HUMAN;tr|C9J2Q2|C9J2Q2_HUMAN;tr|K7ELC1|K7ELC1_HUMAN","sp|Q8N5M1|ATPF2_HUMAN;tr|C9J2Q2|C9J2Q2_HUMAN",3244,"Q8N5M1","ATPF2_HUMAN","ATP synthase mitochondrial F1 complex assembly factor 2",null,"ATPAF2"]
["19.8142","20.3395","19.8951",1,{"$nulls":3},"oxidation-reduction process",{"$nulls":5},2,2,2,"21.7","21.7","21.7","22.917","0.00026462","7.5396",38103000,9,"0.381468",1,"9.62933","1.01885","tr|H3BM30|H3BM30_HUMAN;sp|Q9BV79|MECR_HUMAN","tr|H3BM30|H3BM30_HUMAN;sp|Q9BV79|MECR_HUMAN",4002,"H3BM30","H3BM30_HUMAN",null,null,"MECR"]
["19.1838","17.9126",1,"16.9516",{"$nulls":3},"negative regulation of transcription elongation from RNA polymerase II promoter;positive regulation of cell proliferation;positive regulation of transcription elongation from RNA polymerase II promoter",null,"cytoplasm;nucleus",{"$nulls":3},5,5,5,"22.5","22.5","22.5","32.762",0,"8.6547",72181000,10,"0.450825",1,"9.57237","1.19638","sp|Q56P03|EAPP_HUMAN;tr|G3V2W9|G3V2W9_HUMAN;tr|A0A087X060|A0A087X060_HUMAN","sp|Q56P03|EAPP_HUMAN;tr|G3V2W9|G3V2W9_HUMAN;tr|A0A087X060|A0A087X060_HUMAN",2672,"Q56P03","EAPP_HUMAN","E2F-associated phosphoprotein","APP","EAPP"]
["20.2068","19.8546","19.969",1,{"$nulls":3},"multicellular organism development","DNA binding;RNA binding;zinc ion binding","chromosome;cytoplasm;nucleus",{"$nulls":3},7,7,7,"8.8","8.8","8.8","117.01",0,"30.999",357930000,19,"0.376521",1,"9.54618","1.00633","sp|Q96KR1|ZFR_HUMAN","sp|Q96KR1|ZFR_HUMAN",3762,"Q96KR1","ZFR_HUMAN","Zinc finger RNA-binding protein","ZFR","ZFR"]
["18.9206","19.1027","17.9963",1,{"$nulls":3},"mitochondrial DNA repair;mitochondrial DNA replication;mitochondrial genome maintenance","DNA binding;single-stranded DNA exodeoxyribonuclease activity","mitochondrion",{"$nulls":3},3,3,3,"9.6","9.6","9.6","39.42","0.00026441","7.5197",47261000,11,"0.420952",1,"9.51348","1.11941","sp|Q9BQP7|MGME1_HUMAN;tr|Q5QPE8|Q5QPE8_HUMAN;tr|Q5QPE7|Q5QPE7_HUMAN","sp|Q9BQP7|MGME1_HUMAN;tr|Q5QPE8|Q5QPE8_HUMAN",3923,"Q9BQP7","MGME1_HUMAN","Mitochondrial genome maintenance exonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03030}",null,"MGME1"]
["19.8634","19.8328","19.6721",1,{"$nulls":3},"mRNA 3'-end processing;mRNA splicing, via spliceosome;termination of RNA polymerase II transcription","RNA binding","nucleoplasm","mRNA surveillance pathway",null,null,7,7,7,23,23,23,"48.357",0,"16.468",105410000,14,"0.381465",1,"9.512","1.01884","sp|Q05048|CSTF1_HUMAN;tr|A0A0A0MSZ9|A0A0A0MSZ9_HUMAN;tr|A3KFI9|A3KFI9_HUMAN","sp|Q05048|CSTF1_HUMAN;tr|A0A0A0MSZ9|A0A0A0MSZ9_HUMAN",2098,"Q05048","CSTF1_HUMAN","Cleavage stimulation factor subunit 1",null,"CSTF1"]
["19.1248","20.0223","19.1301",1,{"$nulls":9},1,1,1,25,25,25,"7.6896","0.0013112","3.8424",20371000,1,"0.392818",1,"9.50851","1.04764","tr|H3BR38|H3BR38_HUMAN;tr|H3BM50|H3BM50_HUMAN;tr|H3BPU5|H3BPU5_HUMAN;tr|H3BR25|H3BR25_HUMAN;tr|H3BPT1|H3BPT1_HUMAN;tr|H3BN58|H3BN58_HUMAN;tr|H3BSZ4|H3BSZ4_HUMAN;sp|Q9BVC4|LST8_HUMAN;tr|A0A0A0MR05|A0A0A0MR05_HUMAN","tr|H3BR38|H3BR38_HUMAN;tr|H3BM50|H3BM50_HUMAN;tr|H3BPU5|H3BPU5_HUMAN;tr|H3BR25|H3BR25_HUMAN;tr|H3BPT1|H3BPT1_HUMAN;tr|H3BN58|H3BN58_HUMAN;tr|H3BSZ4|H3BSZ4_HUMAN;sp|Q9BVC4|LST8_HUMAN;tr|A0A0A0MR05|A0A0A0MR05_HUMAN",4005,"H3BR38","H3BR38_HUMAN",null,null,"MLST8"]
["19.808","20.1139","19.929",1,{"$nulls":3},"nervous system development",null,"integral component of membrane",{"$nulls":3},2,2,2,"8.9","8.9","8.9","32.513","0.0002348","5.0377",113820000,13,"0.375303",1,"9.49645","1.00325","sp|Q5BJD5|TM41B_HUMAN;tr|E9PJ42|E9PJ42_HUMAN","sp|Q5BJD5|TM41B_HUMAN;tr|E9PJ42|E9PJ42_HUMAN",2677,"Q5BJD5","TM41B_HUMAN","Transmembrane protein 41B",null,"TMEM41B"]
["23.0184","20.1185","23.152",1,{"$nulls":3},"negative regulation of apoptotic process;oxidation-reduction process",null,"integral component of membrane;mitochondrial inner membrane;respiratory chain",{"$nulls":3},1,1,1,"27.4","27.4","27.4","11.528",0,"28.069",175470000,4,"0.314305",1,"9.49242","0.849777","sp|Q9BW72|HIG2A_HUMAN","sp|Q9BW72|HIG2A_HUMAN",4025,"Q9BW72","HIG2A_HUMAN","HIG1 domain family member 2A, mitochondrial",null,"HIGD2A"]
["19.9902","19.8837","19.907",1,{"$nulls":9},2,2,2,"48.3","48.3","48.3","9.5168",0,"30.143",38077000,11,"0.375268",1,"9.48347","1.00316","tr|H0YMW8|H0YMW8_HUMAN;tr|H0YNF3|H0YNF3_HUMAN;tr|H0YMR6|H0YMR6_HUMAN;tr|H0YLE6|H0YLE6_HUMAN;tr|H0YL55|H0YL55_HUMAN;tr|H7BXE3|H7BXE3_HUMAN;sp|Q9NWH9|SLTM_HUMAN;tr|H0YLW7|H0YLW7_HUMAN;tr|H0YKU6|H0YKU6_HUMAN","tr|H0YMW8|H0YMW8_HUMAN;tr|H0YNF3|H0YNF3_HUMAN;tr|H0YMR6|H0YMR6_HUMAN;tr|H0YLE6|H0YLE6_HUMAN;tr|H0YL55|H0YL55_HUMAN;tr|H7BXE3|H7BXE3_HUMAN;sp|Q9NWH9|SLTM_HUMAN;tr|H0YLW7|H0YLW7_HUMAN;tr|H0YKU6|H0YKU6_HUMAN",4514,"H0YMW8","H0YMW8_HUMAN",null,null,"SLTM"]
["18.694","20.1827",1,"18.9165",{"$nulls":3},"cytolysis;defense response to bacterium;metabolic process","lysozyme activity",{"$nulls":4},1,1,1,"11.5","11.5","11.5","11.488",0,"13.352",73651000,12,"0.395564",1,"9.48009","1.05462","tr|F8VV32|F8VV32_HUMAN;tr|A0A0B4J259|A0A0B4J259_HUMAN;sp|P61626|LYSC_HUMAN","tr|F8VV32|F8VV32_HUMAN;tr|A0A0B4J259|A0A0B4J259_HUMAN;sp|P61626|LYSC_HUMAN",1852,"F8VV32","F8VV32_HUMAN","Lysozyme {ECO:0000256|SAAS:SAAS00858882}",null,"LYZ"]
["18.5866","19.7822",1,"18.4557",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;positive regulation of mRNA splicing, via spliceosome;RNA splicing;RNA splicing, via transesterification reactions","RNA binding","nucleoplasm;spliceosomal complex;U12-type spliceosomal complex","Spliceosome",null,null,1,1,1,"3.3","3.3","3.3","44.385",0,"11.446",139260000,19,"0.40591",1,"9.45656","1.08096","sp|Q15427|SF3B4_HUMAN","sp|Q15427|SF3B4_HUMAN",2489,"Q15427","SF3B4_HUMAN","Splicing factor 3B subunit 4",null,"SF3B4"]
["19.452","21.2757",1,"20.8473",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,"11.7","11.7","11.7","21.233","0.00026028","7.2157",111330000,9,"0.353127",1,"9.44017","0.94729","tr|A0A0A6YYA0|A0A0A6YYA0_HUMAN;sp|Q9Y3B3|TMED7_HUMAN;tr|G3V2Y2|G3V2Y2_HUMAN","tr|A0A0A6YYA0|A0A0A6YYA0_HUMAN;sp|Q9Y3B3|TMED7_HUMAN;tr|G3V2Y2|G3V2Y2_HUMAN",4973,"A0A0A6YYA0","A0A0A6YYA0_HUMAN",null,null,"TMED7-TICAM2"]
["20.3315","20.1229","20.5775",1,{"$nulls":4},"nucleic acid binding",{"$nulls":4},5,5,3,"37.4","37.4","28.9","20.732",0,"28.273",822700000,70,"0.35982",1,"9.43839","0.964151","tr|H0YJV7|H0YJV7_HUMAN;sp|P25490|TYY1_HUMAN;tr|H0YJU4|H0YJU4_HUMAN;sp|Q96MM3|ZFP42_HUMAN","tr|H0YJV7|H0YJV7_HUMAN;sp|P25490|TYY1_HUMAN;tr|H0YJU4|H0YJU4_HUMAN",1223,"H0YJV7","H0YJV7_HUMAN",null,null,"YY1"]
["21.3793","19.8418","21.4092",1,{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,2,2,2,"38.5","38.5","38.5","7.6191","0.000251","6.4392",91157000,22,"0.341935",1,"9.40594","0.919132","sp|O75394|RM33_HUMAN","sp|O75394|RM33_HUMAN",562,"O75394","RM33_HUMAN","39S ribosomal protein L33, mitochondrial","33mt;RP-L33","MRPL33"]
["17.9208","18.3342","16.4887",1,{"$nulls":3},"cell differentiation;mitochondrial transport;nervous system development","kinesin binding","cytoskeleton;mitochondrion",{"$nulls":3},4,4,4,"13.7","13.7","13.7","71.813",0,"8.5762",62082000,9,"0.456529",1,"9.38316","1.21118","sp|Q96EK5|KBP_HUMAN;tr|A0A0D9SFK7|A0A0D9SFK7_HUMAN","sp|Q96EK5|KBP_HUMAN;tr|A0A0D9SFK7|A0A0D9SFK7_HUMAN",3664,"Q96EK5","KBP_HUMAN","KIF1-binding protein {ECO:0000305|PubMed:16225668}",null,"KIF1BP"]
["18.6016","21.1797",1,"20.1296",{"$nulls":4},"RNA binding","nucleolus",{"$nulls":3},3,3,3,"34.8","34.8","34.8","15.017",0,"31.433",410870000,60,"0.360667",1,"9.32588","0.966288","tr|D6RC52|D6RC52_HUMAN;tr|D6RCB9|D6RCB9_HUMAN;sp|Q9NX24|NHP2_HUMAN;tr|J3QSY4|J3QSY4_HUMAN;tr|H0YC83|H0YC83_HUMAN","tr|D6RC52|D6RC52_HUMAN;tr|D6RCB9|D6RCB9_HUMAN;sp|Q9NX24|NHP2_HUMAN;tr|J3QSY4|J3QSY4_HUMAN",4531,"D6RC52","D6RC52_HUMAN",null,null,"NHP2"]
["22.3029","18.7306",1,"21.4572",{"$nulls":3},"branchiomotor neuron axon guidance;dichotomous subdivision of terminal units involved in salivary gland branching;multicellular organism development;neuron projection extension;regulation of axon extension involved in axon guidance;regulation of smooth muscle cell migration","receptor activity;semaphorin receptor activity","extracellular exosome;integral component of membrane;plasma membrane;semaphorin receptor complex","Axon guidance",null,null,3,3,2,"1.3","1.3","0.7","211.06","0.0025152","3.2854",1372900000,7,"0.33214",1,"9.28817","0.894524","sp|Q9UIW2|PLXA1_HUMAN","sp|Q9UIW2|PLXA1_HUMAN",4760,"Q9UIW2","PLXA1_HUMAN","Plexin-A1",null,"PLXNA1"]
["17.1247","17.0017","14.5566",1,{"$nulls":3},"regulation of transcription, DNA-templated;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","DNA binding;RNA binding","cytosol;nuclear speck;nucleoplasm;nucleus;transcription factor TFIID complex;transcription factor TFIIE complex","Basal transcription factors;Viral carcinogenesis",null,null,9,9,9,"42.3","42.3","42.3","33.043",0,"34.834",195940000,34,"0.516735",1,"9.28496","1.36975","sp|P29084|T2EB_HUMAN;tr|E5RH41|E5RH41_HUMAN;tr|E5RIW4|E5RIW4_HUMAN;tr|E5RK24|E5RK24_HUMAN","sp|P29084|T2EB_HUMAN;tr|E5RH41|E5RH41_HUMAN",1277,"P29084","T2EB_HUMAN","Transcription initiation factor IIE subunit beta","FIIE-beta","GTF2E2"]
["19.0445","19.7766","19.2798",1,{"$nulls":3},"cellular response to nitric oxide;collagen catabolic process;extracellular matrix disassembly;negative regulation of hydrogen peroxide metabolic process;positive regulation of oxidative stress-induced cell death;positive regulation of protein oligomerization;proteolysis","endopeptidase activity;metalloendopeptidase activity;metallopeptidase activity;serine-type endopeptidase activity;zinc ion binding","extracellular region;extracellular space;proteinaceous extracellular matrix","IL-17 signaling pathway;Prostate cancer;Rheumatoid arthritis;TNF signaling pathway;Transcriptional misregulation in cancer",null,null,2,2,2,4,4,4,"53.977","0.004499","2.9237",122440000,6,"0.379354",1,"9.27067","1.0135","sp|P08254|MMP3_HUMAN;tr|H7C139|H7C139_HUMAN","sp|P08254|MMP3_HUMAN;tr|H7C139|H7C139_HUMAN",921,"P08254","MMP3_HUMAN","Stromelysin-1","L-1","MMP3"]
["19.6873","19.4626","19.6381",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"18.5","18.5","18.5","13.105","0.00067084","4.1583",26987000,4,"0.371311",1,"9.25589","0.993153","tr|H3BN27|H3BN27_HUMAN;tr|A0A087WYE0|A0A087WYE0_HUMAN;sp|Q9Y342|PLLP_HUMAN","tr|H3BN27|H3BN27_HUMAN;tr|A0A087WYE0|A0A087WYE0_HUMAN;sp|Q9Y342|PLLP_HUMAN",4961,"H3BN27","H3BN27_HUMAN",null,null,"PLLP"]
["21.1336","19.5391","21.1889",1,{"$nulls":9},2,2,2,17,17,17,"11.181","0.00068713","4.523",92146000,12,"0.339378",1,"9.24194","0.912705","tr|I3L4C5|I3L4C5_HUMAN;sp|Q9H832|UBE2Z_HUMAN","tr|I3L4C5|I3L4C5_HUMAN;sp|Q9H832|UBE2Z_HUMAN",4251,"I3L4C5","I3L4C5_HUMAN",null,null,"UBE2Z"]
["19.436","18.9637","18.9548",1,{"$nulls":4},"RNA binding","extracellular region;microfibril;nucleus",{"$nulls":3},10,10,10,"34.6","34.6","34.6","51.958",0,"34.68",332970000,53,"0.384661",1,"9.22242","1.02694","sp|P55081|MFAP1_HUMAN","sp|P55081|MFAP1_HUMAN",1754,"P55081","MFAP1_HUMAN","Microfibrillar-associated protein 1 {ECO:0000312|HGNC:HGNC:7032}",null,"MFAP1"]
["19.3566","18.4695","18.4137",1,{"$nulls":3},"embryonic morphogenesis",null,"tRNA-splicing ligase complex",{"$nulls":3},2,2,2,"13.7","13.7","13.7","21.356","0.0074495","2.4533",19919000,4,"0.396099",1,"9.20618","1.05598","tr|C9J4K0|C9J4K0_HUMAN;sp|Q9BVC5|ASHWN_HUMAN","tr|C9J4K0|C9J4K0_HUMAN;sp|Q9BVC5|ASHWN_HUMAN",4006,"C9J4K0","C9J4K0_HUMAN",null,null,"C2orf49"]
["19.3297","19.7517","19.7007",1,{"$nulls":9},1,1,1,27,27,27,"6.7737","0.002336","3.4184",19293000,6,"0.367147",1,"9.19034","0.982638","tr|H7C613|H7C613_HUMAN;tr|H7C5T6|H7C5T6_HUMAN;tr|C9JB06|C9JB06_HUMAN;sp|Q8N5I4|DHRSX_HUMAN","tr|H7C613|H7C613_HUMAN;tr|H7C5T6|H7C5T6_HUMAN;tr|C9JB06|C9JB06_HUMAN;sp|Q8N5I4|DHRSX_HUMAN",3241,"H7C613","H7C613_HUMAN",null,null,"DHRSX"]
["17.3868","19.7429","17.7846",1,{"$nulls":3},"protein folding","unfolded protein binding","cytosol;peroxisomal membrane",{"$nulls":3},3,3,3,"16.4","16.4","16.4","33.526",0,"8.0275",36107000,6,"0.406463",1,"9.1726","1.08237","sp|Q99614|TTC1_HUMAN;tr|H0YB37|H0YB37_HUMAN","sp|Q99614|TTC1_HUMAN",3866,"Q99614","TTC1_HUMAN","Tetratricopeptide repeat protein 1","PR repeat protein 1","TTC1"]
["16.4462","20.7551","17.9039",1,{"$nulls":3},"BMP signaling pathway;cell development;cell-cell signaling;positive regulation of myoblast fusion;positive regulation of pathway-restricted SMAD protein phosphorylation;regulation of apoptotic process;regulation of MAPK cascade;signal transduction;SMAD protein signal transduction;transforming growth factor beta receptor signaling pathway","cytokine activity;growth factor activity;transforming growth factor beta receptor binding","cytoplasm;extracellular exosome;extracellular region;extracellular space;nucleus","Cytokine-cytokine receptor interaction",null,null,7,7,7,"28.9","28.9","28.9","34.14",0,"38.072",329880000,26,"0.393313",1,"9.1487","1.0489","sp|Q99988|GDF15_HUMAN;tr|A0A0A0MTT8|A0A0A0MTT8_HUMAN","sp|Q99988|GDF15_HUMAN",3899,"Q99988","GDF15_HUMAN","Growth/differentiation factor 15","DF-15","GDF15"]
["18.9296","19.3275","19.0013",1,{"$nulls":5},"mitochondrion",{"$nulls":3},2,2,2,"23.8","23.8","23.8","17.167","0.00026015","7.2131",47273000,7,"0.379508",1,"9.12789","1.01389","tr|E9PIQ7|E9PIQ7_HUMAN;sp|O00165|HAX1_HUMAN;tr|Q5VYD6|Q5VYD6_HUMAN","tr|E9PIQ7|E9PIQ7_HUMAN;sp|O00165|HAX1_HUMAN;tr|Q5VYD6|Q5VYD6_HUMAN",193,"E9PIQ7","E9PIQ7_HUMAN",null,null,"HAX1"]
["15.2379","16.1179",1,"12.1015",{"$nulls":3},"DNA recombination;DNA repair;DNA replication;DNA synthesis involved in DNA repair;humoral immune response mediated by circulating immunoglobulin;isotype switching;meiotic cell cycle;mismatch repair;regulation of signal transduction by p53 class mediator;somatic hypermutation of immunoglobulin genes;strand displacement;t-circle formation","5'-3' exodeoxyribonuclease activity;5'-3' exonuclease activity;chromatin binding;DNA binding;double-stranded DNA 5'-3' exodeoxyribonuclease activity;exonuclease activity;flap endonuclease activity;metal ion binding;RNA-DNA hybrid ribonuclease activity;single-stranded DNA 5'-3' exodeoxyribonuclease activity","nuclear body;nucleoplasm;nucleus","Mismatch repair",null,null,9,9,9,"14.5","14.5","14.5","94.102",0,"22.152",170760000,30,"0.614661",1,"9.12716","1.63917","sp|Q9UQ84|EXO1_HUMAN;tr|H0YAZ2|H0YAZ2_HUMAN","sp|Q9UQ84|EXO1_HUMAN",4879,"Q9UQ84","EXO1_HUMAN","Exonuclease 1","Exo1","EXO1"]
["18.0825","19.1804","18.018",1,{"$nulls":3},"apoptotic process;cell differentiation;Wnt signaling pathway","actin binding",{"$nulls":4},4,2,2,"27.7","19.3","19.3","22.195",0,"8.0639",117410000,16,"0.40156",1,"9.12247","1.06987","sp|Q9BQE9|BCL7B_HUMAN;tr|F2Z3H6|F2Z3H6_HUMAN","sp|Q9BQE9|BCL7B_HUMAN;tr|F2Z3H6|F2Z3H6_HUMAN",3920,"Q9BQE9","BCL7B_HUMAN","B-cell CLL/lymphoma 7 protein family member B",null,"BCL7B"]
["20.0002","19.3636","20.1286",1,{"$nulls":3},"cellular iron ion homeostasis;iron ion transport","ferric iron binding","cell",{"$nulls":3},2,2,2,23,23,23,"12.876","0.0013103","3.84",37999000,4,"0.355303",1,"9.11759","0.952769","tr|G3V1D1|G3V1D1_HUMAN;tr|G3V192|G3V192_HUMAN;sp|P02794|FRIH_HUMAN;tr|E9PPQ4|E9PPQ4_HUMAN","tr|G3V1D1|G3V1D1_HUMAN;tr|G3V192|G3V192_HUMAN;sp|P02794|FRIH_HUMAN;tr|E9PPQ4|E9PPQ4_HUMAN",824,"G3V1D1","G3V1D1_HUMAN","Ferritin {ECO:0000256|RuleBase:RU361145}"]
["20.7982","19.2473","20.862",1,{"$nulls":3},"fatty acid catabolic process","acyl-CoA hydrolase activity;metal ion binding;receptor binding","mitochondrion;peroxisomal matrix","Peroxisome",null,null,6,6,6,"23.2","23.2","23.2","42.233",0,"14.495",183360000,20,"0.339379",1,"9.09172","0.912708","sp|A8MXV4|NUD19_HUMAN","sp|A8MXV4|NUD19_HUMAN",179,"A8MXV4","NUD19_HUMAN","Nucleoside diphosphate-linked moiety X motif 19","udix motif 19","NUDT19"]
["19.0573","19.2444","19.1196",1,{"$nulls":3},"base-excision repair","uracil DNA N-glycosylase activity",{"$nulls":4},2,2,2,17,17,17,"15.646","0.0002495","6.3273",38759000,4,"0.375364",1,"9.09107","1.0034","tr|Q68DM5|Q68DM5_HUMAN;tr|F5GYA2|F5GYA2_HUMAN;sp|P13051|UNG_HUMAN","tr|Q68DM5|Q68DM5_HUMAN;tr|F5GYA2|F5GYA2_HUMAN;sp|P13051|UNG_HUMAN",1021,"Q68DM5","Q68DM5_HUMAN",null,null,"UNG"]
["19.7788","18.4929","19.0933",1,{"$nulls":3},"mitochondrial respiratory chain complex I assembly;mitochondrial respiratory chain complex III assembly;mitochondrial respiratory chain complex IV assembly;mitochondrion organization","ATP binding","integral component of membrane;mitochondrial respiratory chain complex III;mitochondrion",{"$nulls":3},3,3,3,"8.6","8.6","8.6","47.534","0.00023987","5.4863",82110000,3,"0.374878",1,"9.08917","1.00217","sp|Q9Y276|BCS1_HUMAN;tr|H7C492|H7C492_HUMAN;tr|C9J1S9|C9J1S9_HUMAN","sp|Q9Y276|BCS1_HUMAN;tr|H7C492|H7C492_HUMAN",4899,"Q9Y276","BCS1_HUMAN","Mitochondrial chaperone BCS1",{"$f":"-#REF!","v":{"$error":"#REF!"}},"BCS1L"]
["18.6301","19.4779","18.9484",1,{"$nulls":3},"negative regulation of fat cell differentiation","13-prostaglandin reductase activity;15-oxoprostaglandin 13-oxidase activity;zinc ion binding","mitochondrion;peroxisome",{"$nulls":3},1,1,1,4,4,4,"40.14","0.00069013","4.613",69330000,7,"0.378224",1,"9.07978","1.01064","sp|Q8N4Q0|ZADH2_HUMAN","sp|Q8N4Q0|ZADH2_HUMAN",3226,"Q8N4Q0","PTGR3_HUMAN","Prostaglandin reductase 3","RG-3","ZADH2"]
["18.8548","19.5533","19.3389",1,{"$nulls":5},"cytosol;nucleoplasm",{"$nulls":3},2,2,2,"21.8","21.8","21.8","21.537","0.00023491","5.0455",35299000,6,"0.367917",1,"9.0346","0.984581","tr|Q5TD07|Q5TD07_HUMAN;sp|P16083|NQO2_HUMAN;tr|Q5TD05|Q5TD05_HUMAN","tr|Q5TD07|Q5TD07_HUMAN;sp|P16083|NQO2_HUMAN;tr|Q5TD05|Q5TD05_HUMAN",1070,"Q5TD07","Q5TD07_HUMAN",null,null,"NQO2"]
["18.5709","19.0696","18.586",1,{"$nulls":3},"hematopoietic progenitor cell differentiation",null,"cytosol",{"$nulls":3},5,5,5,"18.8","18.8","18.8","54.141",0,"26.562",91956000,16,"0.38438",1,"9.02727","1.02623","sp|Q6NXE6|ARMC6_HUMAN;tr|F5H2X2|F5H2X2_HUMAN;tr|F5H2K4|F5H2K4_HUMAN;tr|F5GWV0|F5GWV0_HUMAN;tr|F5H4P3|F5H4P3_HUMAN;tr|B4E1N1|B4E1N1_HUMAN;tr|F5H052|F5H052_HUMAN;tr|F5H3X1|F5H3X1_HUMAN;tr|H0YGL0|H0YGL0_HUMAN;tr|H0YGQ5|H0YGQ5_HUMAN;tr|H0YH65|H0YH65_HUMAN;tr|F5H6J3|F5H6J3_HUMAN","sp|Q6NXE6|ARMC6_HUMAN;tr|F5H2X2|F5H2X2_HUMAN;tr|F5H2K4|F5H2K4_HUMAN;tr|F5GWV0|F5GWV0_HUMAN;tr|F5H4P3|F5H4P3_HUMAN;tr|B4E1N1|B4E1N1_HUMAN",2840,"Q6NXE6","ARMC6_HUMAN","Armadillo repeat-containing protein 6",null,"ARMC6"]
["19.9844","19.5362","20.5248",1,{"$nulls":9},2,2,2,21,21,21,"15.956","0.00025407","6.7008",39246000,5,"0.342858",1,"8.99794","0.921451","tr|H0YNP9|H0YNP9_HUMAN;sp|Q8N4P3|MESH1_HUMAN;tr|H0YKT9|H0YKT9_HUMAN","tr|H0YNP9|H0YNP9_HUMAN;sp|Q8N4P3|MESH1_HUMAN;tr|H0YKT9|H0YKT9_HUMAN",3225,"H0YNP9","H0YNP9_HUMAN",null,null,"HDDC3"]
["22.1598","19.1496","22.3482",1,{"$nulls":9},2,2,2,"53.4","53.4","53.4","11.246","0.00025164","6.4973",64034000,2,"0.307654",1,"8.98059","0.833102","tr|K7EJQ6|K7EJQ6_HUMAN;tr|K7EPQ7|K7EPQ7_HUMAN;tr|K7ERQ0|K7ERQ0_HUMAN;tr|K7ERY2|K7ERY2_HUMAN;sp|Q5BJH7|YIF1B_HUMAN","tr|K7EJQ6|K7EJQ6_HUMAN;tr|K7EPQ7|K7EPQ7_HUMAN;tr|K7ERQ0|K7ERQ0_HUMAN;tr|K7ERY2|K7ERY2_HUMAN;sp|Q5BJH7|YIF1B_HUMAN",5279,"K7EJQ6","K7EJQ6_HUMAN",null,null,"YIF1B"]
["18.5751","18.8731","18.5236",1,{"$nulls":3},"tRNA-type intron splice site recognition and cleavage","tRNA-intron endonuclease activity","nucleus;tRNA-intron endonuclease complex",{"$nulls":3},3,3,3,"18.2","18.2","18.2","26.101",0,"8.7365",33559000,7,"0.383002",1,"8.96232","1.02274","tr|B0V3J0|B0V3J0_HUMAN;tr|A9C4B9|A9C4B9_HUMAN;tr|A0A0G2JNK5|A0A0G2JNK5_HUMAN;tr|A0A024R4N9|A0A024R4N9_HUMAN;sp|Q9BSV6|SEN34_HUMAN;tr|E7EQB3|E7EQB3_HUMAN","tr|B0V3J0|B0V3J0_HUMAN;tr|A9C4B9|A9C4B9_HUMAN;tr|A0A0G2JNK5|A0A0G2JNK5_HUMAN;tr|A0A024R4N9|A0A024R4N9_HUMAN;sp|Q9BSV6|SEN34_HUMAN;tr|E7EQB3|E7EQB3_HUMAN",3955,"B0V3J0","B0V3J0_HUMAN",null,null,"TSEN34"]
["18.8873","18.1891","18.1649",1,{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear mRNA surveillance;nuclear polyadenylation-dependent mRNA catabolic process;nuclear polyadenylation-dependent rRNA catabolic process;nuclear polyadenylation-dependent tRNA catabolic process;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';regulation of mRNA stability;RNA catabolic process;rRNA processing;U1 snRNA 3'-end processing;U4 snRNA 3'-end processing;U5 snRNA 3'-end processing","3'-5'-exoribonuclease activity;AU-rich element binding;RNA binding","cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);nuclear exosome (RNase complex);nucleolus;nucleoplasm","RNA degradation",null,null,2,2,2,"8.6","8.6","8.6","31.821","0.00025284","6.5862",40149000,7,"0.390845",1,"8.95572","1.04263","sp|Q15024|EXOS7_HUMAN","sp|Q15024|EXOS7_HUMAN",2429,"Q15024","EXOS7_HUMAN","Exosome complex component RRP42",null,"EXOSC7"]
["18.9605","17.5884",1,"17.6489",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;NLS-bearing protein import into nucleus;nuclear pore organization;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of transcription, DNA-templated;tRNA export from nucleus;viral process;viral transcription","nucleocytoplasmic transporter activity;phospholipid binding;single-stranded DNA binding","host cell;nuclear envelope;nuclear lamina;nuclear membrane;nuclear pore central transport channel;nuclear pore nuclear basket;nucleoplasm;plasma membrane","RNA transport",null,null,2,2,2,"9.8","9.8","9.8","34.773","0.00066994","4.138",47070000,3,"0.402204",1,"8.95002","1.07151","sp|Q8NFH5|NUP53_HUMAN;tr|C9IYQ7|C9IYQ7_HUMAN;tr|F8WCF5|F8WCF5_HUMAN;tr|F8WEL4|F8WEL4_HUMAN","sp|Q8NFH5|NUP53_HUMAN;tr|C9IYQ7|C9IYQ7_HUMAN;tr|F8WCF5|F8WCF5_HUMAN;tr|F8WEL4|F8WEL4_HUMAN",3340,"Q8NFH5","NUP53_HUMAN","Nucleoporin NUP53",null,"NUP35"]
["19.4436","18.8679",1,"19.4124",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;neutrophil degranulation","NADH dehydrogenase (ubiquinone) activity","azurophil granule membrane;cytoplasm;integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion;plasma membrane","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,3,3,3,"22.7","22.7","22.7","14.187","0.00066152","3.9801",37941000,5,"0.362789",1,"8.94949","0.971639","sp|O95298|NDUC2_HUMAN;tr|E9PRJ5|E9PRJ5_HUMAN;tr|E9PRQ4|E9PRQ4_HUMAN;tr|A0A087WY27|A0A087WY27_HUMAN;tr|E9PM14|E9PM14_HUMAN;sp|E9PQ53|NDUCR_HUMAN;tr|A0A087WUM3|A0A087WUM3_HUMAN","sp|O95298|NDUC2_HUMAN;tr|E9PRJ5|E9PRJ5_HUMAN",713,"O95298","NDUC2_HUMAN","NADH dehydrogenase [ubiquinone] 1 subunit C2",null,"NDUFC2"]
["18.0286","15.7883",1,"14.9695",{"$nulls":3},"neuron migration;protein O-linked glycosylation;protein O-linked mannosylation","acetylglucosaminyltransferase activity;protein O-GlcNAc transferase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Mannose type O-glycan biosynthesis;Metabolic pathways",null,null,7,7,7,"16.9","16.9","16.9","66.615",0,"24.942",200200000,18,"0.475812",1,"8.92373","1.26148","sp|Q8NAT1|PMGT2_HUMAN","sp|Q8NAT1|PMGT2_HUMAN",3273,"Q8NAT1","PMGT2_HUMAN","Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 {ECO:0000303|PubMed:23929950}","OMGnT2 {ECO:0000303|PubMed:23929950}","POMGNT2"]
["16.5485","18.9738","16.6821",1,{"$nulls":4},"DNA binding;zinc ion binding",{"$nulls":4},3,3,3,"37.9","37.9","37.9","22.54","0.0013138","3.8665",18383000,6,"0.422841",1,"8.9201","1.12425","tr|Q5QPB1|Q5QPB1_HUMAN;sp|O76080|ZFAN5_HUMAN","tr|Q5QPB1|Q5QPB1_HUMAN;sp|O76080|ZFAN5_HUMAN",5293,"Q5QPB1","Q5QPB1_HUMAN",null,null,"ZFAND5"]
["18.5723","18.7282","18.4819",1,{"$nulls":9},3,3,3,"23.3","23.3","23.3","15.512","0.00066607","4.0741",11675000,2,"0.381613",1,"8.90929","1.01922","tr|K7EQH1|K7EQH1_HUMAN;tr|A0A087WVF1|A0A087WVF1_HUMAN;sp|Q96B23|CR025_HUMAN;tr|Q5BIX2|Q5BIX2_HUMAN","tr|K7EQH1|K7EQH1_HUMAN;tr|A0A087WVF1|A0A087WVF1_HUMAN;sp|Q96B23|CR025_HUMAN;tr|Q5BIX2|Q5BIX2_HUMAN",3608,"K7EQH1","K7EQH1_HUMAN",null,null,"C18orf25"]
["19.454","18.9923","19.6355",1,{"$nulls":3},"ubiquitin-dependent protein catabolic process",{"$nulls":5},3,3,3,"16.6","16.6","16.6","18.72","0.00025227","6.5419",46684000,7,"0.356371",1,"8.90546","0.95546","tr|E5RJR5|E5RJR5_HUMAN;sp|P63208|SKP1_HUMAN;tr|E5RGM3|E5RGM3_HUMAN;tr|E7ERH2|E7ERH2_HUMAN;tr|F8W8N3|F8W8N3_HUMAN","tr|E5RJR5|E5RJR5_HUMAN;sp|P63208|SKP1_HUMAN",1943,"E5RJR5","E5RJR5_HUMAN",null,null,"SKP1"]
["19.2414","18.6683","19.11",1,{"$nulls":3},"cytoplasmic mRNA processing body assembly;multicellular organism development;positive regulation of type I interferon-mediated signaling pathway;regulation of translation;RIG-I signaling pathway","double-stranded DNA binding;double-stranded RNA binding;RNA binding;single-stranded RNA binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;P-body",{"$nulls":3},4,4,2,"8.9","8.9","3.9","50.529",0,"44.789",133560000,12,"0.36704",1,"8.89979","0.982366","sp|Q8ND56|LS14A_HUMAN;tr|I3L4Q1|I3L4Q1_HUMAN;tr|A0A0G2JQ95|A0A0G2JQ95_HUMAN;tr|A0A096LP11|A0A096LP11_HUMAN","sp|Q8ND56|LS14A_HUMAN",3313,"Q8ND56","LS14A_HUMAN","Protein LSM14 homolog A",null,"LSM14A"]
["16.9605","17.6959","15.8593",1,{"$nulls":3},"I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;negative regulation of gene expression;negative regulation of interferon-beta production;negative regulation of neuron death;negative regulation of transcription from RNA polymerase II promoter;NIK/NF-kappaB signaling;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of transcription from RNA polymerase II promoter;response to cytokine","chromatin binding;DNA binding transcription factor activity;RNA polymerase II distal enhancer sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding","cytosol;I-kappaB/NF-kappaB complex;nucleoplasm;nucleus;transcription factor complex","Ras signaling pathway;Transcriptional misregulation in cancer;Viral carcinogenesis",null,null,3,3,3,"6.1","6.1","6.1","68.519","0.0023138","3.3254",23610000,2,"0.450773",1,"8.89855","1.19625","sp|Q04864|REL_HUMAN","sp|Q04864|REL_HUMAN",2094,"Q04864","REL_HUMAN","Proto-oncogene c-Rel",null,"REL"]
["18.9936","19.1385",1,"19.3654",{"$nulls":3},"cellular response to growth factor stimulus;cellular response to steroid hormone stimulus;negative regulation of intrinsic apoptotic signaling pathway;negative regulation of phosphatase activity;negative regulation of transcription from RNA polymerase II promoter;regulation of cell growth;regulation of transcription from RNA polymerase II promoter;response to virus;transcription, DNA-templated","chromatin binding;phosphatase inhibitor activity;phosphoprotein binding;protein phosphatase inhibitor activity;RNA polymerase II transcription corepressor activity","cytoplasm;cytosol;dendrite;DNA-directed RNA polymerase II, core complex;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},7,7,7,"18.3","18.3","18.3","59.832",0,"17.771",162280000,12,"0.361096",1,"8.88335","0.96737","sp|O94763|RMP_HUMAN;tr|I3NI51|I3NI51_HUMAN;tr|I3L280|I3L280_HUMAN;tr|I3L2V7|I3L2V7_HUMAN;tr|I3L104|I3L104_HUMAN","sp|O94763|RMP_HUMAN",649,"O94763","RMP_HUMAN","Unconventional prefoldin RPB5 interactor 1",null,"URI1"]
["16.7028","18.57",1,"16.5116",{"$nulls":9},1,1,1,"12.3","12.3","12.3","11.848","0.0013012","3.7275",6051100,2,"0.427738",1,"8.88061","1.13682","tr|A0A087WW12|A0A087WW12_HUMAN;tr|A0A087WZ11|A0A087WZ11_HUMAN;sp|Q6P158|DHX57_HUMAN","tr|A0A087WW12|A0A087WW12_HUMAN;tr|A0A087WZ11|A0A087WZ11_HUMAN;sp|Q6P158|DHX57_HUMAN",2845,"A0A087WW12","A0A087WW12_HUMAN",null,null,"DHX57"]
["19.1237","17.7496","18.1514",1,{"$nulls":5},"cytosol;mitochondrion;nucleus",{"$nulls":3},2,2,2,"9.7","9.7","9.7","28.466","0.00023889","5.4009",23460000,5,"0.385856",1,"8.86098","1.02997","sp|Q9UFN0|NPS3A_HUMAN","sp|Q9UFN0|NPS3A_HUMAN",4698,"Q9UFN0","NPS3A_HUMAN","Protein NipSnap homolog 3A","ipSnap3A","NIPSNAP3A"]
["18.4463","18.783","18.5328",1,{"$nulls":9},1,1,1,"16.2","16.2","16.2","9.116","0.003127","3.2052",12897000,2,"0.377638",1,"8.84825","1.00915","tr|K7ELP6|K7ELP6_HUMAN;sp|Q53F19|NCBP3_HUMAN","tr|K7ELP6|K7ELP6_HUMAN;sp|Q53F19|NCBP3_HUMAN",2646,"K7ELP6","K7ELP6_HUMAN",null,null,"NCBP3"]
["17.761","18.0407","17.1425",1,{"$nulls":4},"arginyltransferase activity",{"$nulls":4},2,2,2,"7.4","7.4","7.4","45.831",0,"25.275",43733000,9,"0.410938",1,"8.8296","1.09379","tr|B4DK25|B4DK25_HUMAN;tr|B4E107|B4E107_HUMAN;tr|F5GXE4|F5GXE4_HUMAN;tr|H0Y5C2|H0Y5C2_HUMAN;sp|O95260|ATE1_HUMAN","tr|B4DK25|B4DK25_HUMAN;tr|B4E107|B4E107_HUMAN;tr|F5GXE4|F5GXE4_HUMAN;tr|H0Y5C2|H0Y5C2_HUMAN;sp|O95260|ATE1_HUMAN",709,"B4DK25","B4DK25_HUMAN","Arginyl-tRNA--protein transferase 1 {ECO:0000256|PIRNR:PIRNR037207}","rginyltransferase 1 {ECO:0000256|PIRNR:PIRNR037207};-transferase 1 {ECO:0000256|PIRNR:PIRNR037207}","ATE1"]
["18.7906","21.0855",1,"21.225",{"$nulls":9},3,3,3,"31.1","31.1","31.1","11.972",0,"10.293",120890000,9,"0.321241",1,"8.82556","0.867173","tr|F5GX77|F5GX77_HUMAN;sp|Q9UI30|TR112_HUMAN;tr|F5GYQ2|F5GYQ2_HUMAN","tr|F5GX77|F5GX77_HUMAN;sp|Q9UI30|TR112_HUMAN",4748,"F5GX77","F5GX77_HUMAN",null,null,"TRMT112"]
["18.4191","18.6778","18.4507",1,{"$nulls":3},"metabolic process","catalytic activity",{"$nulls":4},1,1,1,"14.6","14.6","14.6","19.409","0.0006922","4.69",12726000,4,"0.378406",1,"8.82314","1.0111","tr|K7EKW4|K7EKW4_HUMAN;sp|Q96AB3|ISOC2_HUMAN","tr|K7EKW4|K7EKW4_HUMAN;sp|Q96AB3|ISOC2_HUMAN",3598,"K7EKW4","K7EKW4_HUMAN",null,null,"ISOC2"]
["19.0773","18.344","18.7955",1,{"$nulls":3},"autophagy;ER to Golgi vesicle-mediated transport;Golgi ribbon formation;Golgi to vacuole transport;intra-Golgi vesicle-mediated transport;protein targeting to vacuole;retrograde transport, endosome to Golgi;vesicle fusion with Golgi apparatus;voluntary musculoskeletal movement","SNAP receptor activity;SNARE binding","autophagosome;clathrin-coated vesicle;cytosol;endoplasmic reticulum membrane;endosome;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi membrane;integral component of membrane;intracellular membrane-bounded organelle;late endosome membrane;neuron projection terminus;neuronal cell body;perinuclear region of cytoplasm;SNARE complex;synaptic vesicle;trans-Golgi network membrane","SNARE interactions in vesicular transport",null,null,1,1,1,"10.6","10.6","10.6","25.217","0.00068368","4.4424",22603000,2,"0.369914",1,"8.81291","0.989625","sp|Q96AJ9|VTI1A_HUMAN","sp|Q96AJ9|VTI1A_HUMAN",3602,"Q96AJ9","VTI1A_HUMAN","Vesicle transport through interaction with t-SNAREs homolog 1A",null,"VTI1A"]
["18.8545","18.6208","18.9004",1,{"$nulls":4},"RNA polymerase II transcription cofactor activity","mediator complex;nuclear body;nucleus",{"$nulls":3},4,4,4,"37.3","37.3","37.3","26.287",0,"32.946",278900000,22,"0.36679",1,"8.78748","0.981735","tr|J3KR33|J3KR33_HUMAN;sp|A0JLT2|MED19_HUMAN","tr|J3KR33|J3KR33_HUMAN;sp|A0JLT2|MED19_HUMAN",151,"J3KR33","J3KR33_HUMAN","Mediator of RNA polymerase II transcription subunit 19 {ECO:0000256|RuleBase:RU364151}"]
["19.1881","18.8481",1,"19.4717",{"$nulls":9},3,3,3,"21.6","21.6","21.6","23.266","0.00026511","7.5826",42643000,8,"0.354494",1,"8.78229","0.950733","tr|F8VTY2|F8VTY2_HUMAN;sp|Q8NFH4|NUP37_HUMAN","tr|F8VTY2|F8VTY2_HUMAN;sp|Q8NFH4|NUP37_HUMAN",3339,"F8VTY2","F8VTY2_HUMAN",null,null,"NUP37"]
["19.0273","18.9007","19.4055",1,{"$nulls":4},"cysteine-type peptidase activity","cytoplasmic ribonucleoprotein granule;cytosol;intracellular membrane-bounded organelle",{"$nulls":3},4,4,4,"13.3","13.3","13.3","36.269","0.00023652","5.1859",79013000,5,"0.355002",1,"8.76131","0.952011","tr|A0A087X0D5|A0A087X0D5_HUMAN;sp|P09668|CATH_HUMAN;tr|E9PKT6|E9PKT6_HUMAN","tr|A0A087X0D5|A0A087X0D5_HUMAN;sp|P09668|CATH_HUMAN;tr|E9PKT6|E9PKT6_HUMAN",953,"A0A087X0D5","A0A087X0D5_HUMAN",null,null,"CTSH"]
["19.3478","18.7793","19.6766",1,{"$nulls":5},"cytosol",{"$nulls":3},2,2,2,22,22,22,"21.556",0,"13.75",30655000,4,"0.347813",1,"8.72521","0.933914","tr|H0YNN4|H0YNN4_HUMAN;tr|H0YNB7|H0YNB7_HUMAN;tr|H0YL22|H0YL22_HUMAN;sp|Q9Y375|CIA30_HUMAN","tr|H0YNN4|H0YNN4_HUMAN;tr|H0YNB7|H0YNB7_HUMAN;tr|H0YL22|H0YL22_HUMAN;sp|Q9Y375|CIA30_HUMAN",4964,"H0YNN4","H0YNN4_HUMAN",null,null,"NDUFAF1"]
["18.2844","18.3595","18.1989",1,{"$nulls":3},"box C/D snoRNP assembly;positive regulation of transcription from RNA polymerase II promoter;protein oligomerization;RNA processing","ATPase binding;DNA binding;identical protein binding;metal ion binding;protein binding, bridging;RNA binding","fibrillar center;nuclear matrix;nucleolus;nucleus;perichromatin fibrils;pre-snoRNP complex;presynaptic active zone;protein complex;transcription elongation factor complex",{"$nulls":3},6,6,6,19,19,19,"56.299",0,"40.059",263330000,31,"0.379669",1,"8.72246","1.01429","sp|Q9UHK0|NUFP1_HUMAN","sp|Q9UHK0|NUFP1_HUMAN",4728,"Q9UHK0","NUFP1_HUMAN","Nuclear fragile X mental retardation-interacting protein 1",null,"NUFIP1"]
["20.7948","18.8596","21.2319",1,{"$nulls":3},"NAD biosynthetic process;NAD metabolic process;protein oligomerization;quinolinate catabolic process","nicotinate-nucleotide diphosphorylase (carboxylating) activity;protein homodimerization activity","cytoplasm;cytosol;extracellular exosome","Metabolic pathways;Nicotinate and nicotinamide metabolism",null,null,5,5,5,"18.2","18.2","18.2","30.845",0,"12.114",144620000,14,"0.317276",1,"8.71125","0.857227","sp|Q15274|NADC_HUMAN;tr|C9JCJ5|C9JCJ5_HUMAN","sp|Q15274|NADC_HUMAN;tr|C9JCJ5|C9JCJ5_HUMAN",2464,"Q15274","NADC_HUMAN","Nicotinate-nucleotide pyrophosphorylase [carboxylating]",null,"QPRT"]
["17.6976","18.7739","18.1",1,{"$nulls":9},4,4,4,"7.1","7.1","7.1","83.069",0,"14.672",61789000,9,"0.379504",1,"8.68578","1.01388","sp|Q8IYQ7|THNS1_HUMAN","sp|Q8IYQ7|THNS1_HUMAN",3169,"Q8IYQ7","THNS1_HUMAN","Threonine synthase-like 1","SH1","THNSL1"]
["19.284","18.7369","19.6727",1,{"$nulls":9},1,1,1,17,17,17,"11.728","0.0023246","3.3676",20957000,3,"0.345727",1,"8.67409","0.928667","tr|M0R1B0|M0R1B0_HUMAN;sp|O43402|EMC8_HUMAN","tr|M0R1B0|M0R1B0_HUMAN;sp|O43402|EMC8_HUMAN",398,"M0R1B0","M0R1B0_HUMAN",null,null,"EMC8"]
["19.2075","18.4791","19.3415",1,{"$nulls":3},"mitochondrial respiratory chain complex IV assembly",null,"integral component of membrane;mitochondrial inner membrane",{"$nulls":3},1,1,1,"8.3","8.3","8.3","18.402","0.0025173","3.2914",31848000,6,"0.352193",1,"8.6726","0.944938","sp|Q8N5G0|SMI20_HUMAN","sp|Q8N5G0|SMI20_HUMAN",3239,"Q8N5G0","SIM20_HUMAN","Small integral membrane protein 20",null,"SMIM20"]
["17.6853","18.8311","18.1843",1,{"$nulls":5},"cytosol;integral component of membrane;nucleoplasm;plasma membrane",{"$nulls":3},1,1,1,4,4,4,"47.597","0.00026062","7.2322",36552000,4,"0.376536",1,"8.66605","1.00637","tr|H0YH69|H0YH69_HUMAN;sp|Q9HBU6|EKI1_HUMAN","tr|H0YH69|H0YH69_HUMAN;sp|Q9HBU6|EKI1_HUMAN",4314,"H0YH69","H0YH69_HUMAN",null,null,"ETNK1"]
["19.1398","18.5752","19.4033",1,{"$nulls":3},"aggrephagy;antigen processing and presentation of endogenous antigen;apoptotic process;autophagosome assembly;autophagy;autophagy of host cells involved in interaction with symbiont;autophagy of mitochondrion;autophagy of nucleus;blood vessel remodeling;cellular homeostasis;cellular response to nitrogen starvation;cellular response to nitrosative stress;C-terminal protein lipidation;heart contraction;macroautophagy;negative regulation of apoptotic process;negative regulation of cell death;negative regulation of histone H4-K16 acetylation;negative regulation of phagocytosis;negative regulation of protein ubiquitination;negative regulation of reactive oxygen species metabolic process;negative stranded viral RNA replication;negative thymic T cell selection;otolith development;positive regulation of mucus secretion;post-translational protein modification;protein lipidation involved in autophagosome assembly;regulation of cilium assembly;regulation of cytokine secretion involved in immune response;regulation of release of sequestered calcium ion into cytosol;response to drug;response to fungus;vasodilation;ventricular cardiac muscle cell development",null,"Atg12-Atg5-Atg16 complex;autophagosome;axoneme;cytoplasm;cytosol;ER-mitochondrion membrane contact site;membrane;phagocytic vesicle membrane;phagophore assembly site membrane","Autophagy - animal;Autophagy - other;Ferroptosis;Longevity regulating pathway;Longevity regulating pathway - multiple species;Mitophagy - animal;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway;Shigellosis",null,null,2,2,2,"8.4","8.4","8.4","32.447","0.0013106","3.8411",38703000,6,"0.350326",1,"8.65583","0.940239","sp|Q9H1Y0|ATG5_HUMAN;tr|L7UQJ2|L7UQJ2_HUMAN","sp|Q9H1Y0|ATG5_HUMAN;tr|L7UQJ2|L7UQJ2_HUMAN",4161,"Q9H1Y0","ATG5_HUMAN","Autophagy protein 5",null,"ATG5"]
["19.7295","18.3601","19.7896",1,{"$nulls":3},"cell division;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;sister chromatid cohesion;tRNA export from nucleus;viral process;viral transcription",null,"condensed chromosome kinetochore;cytosol;host cell;nuclear envelope;nuclear pore outer ring","RNA transport",null,null,2,2,2,"8.2","8.2","8.2","42.15",0,"8.6629",42343000,8,"0.341598",1,"8.65001","0.918285","sp|Q8NFH3|NUP43_HUMAN","sp|Q8NFH3|NUP43_HUMAN",3338,"Q8NFH3","NUP43_HUMAN","Nucleoporin Nup43",null,"NUP43"]
["19.3812","18.7034","19.8218",1,{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process",null,"mitochondrion",{"$nulls":3},3,3,3,"35.5","35.5","35.5","18.919","0.00025056","6.4057",36959000,3,"0.340921",1,"8.63143","0.916582","tr|A0A024RBT2|A0A024RBT2_HUMAN;sp|Q9NR28|DBLOH_HUMAN;tr|F5H796|F5H796_HUMAN;tr|F5H0Q4|F5H0Q4_HUMAN;tr|F5GYH3|F5GYH3_HUMAN;tr|F5GX50|F5GX50_HUMAN;tr|F5GXT8|F5GXT8_HUMAN;tr|H7BZK7|H7BZK7_HUMAN","tr|A0A024RBT2|A0A024RBT2_HUMAN;sp|Q9NR28|DBLOH_HUMAN;tr|F5H796|F5H796_HUMAN",4405,"A0A024RBT2","A0A024RBT2_HUMAN",null,null,"DIABLO"]
["17.614","18.5715","17.9291",1,{"$nulls":9},2,2,2,"22.2","22.2","22.2","19.407","0.0023295","3.3938",11944000,1,"0.381016",1,"8.62819","1.0177","tr|Q5T9P8|Q5T9P8_HUMAN;tr|Q5T9P7|Q5T9P7_HUMAN;sp|Q99633|PRP18_HUMAN;tr|M0R3G1|M0R3G1_HUMAN","tr|Q5T9P8|Q5T9P8_HUMAN;tr|Q5T9P7|Q5T9P7_HUMAN;sp|Q99633|PRP18_HUMAN;tr|M0R3G1|M0R3G1_HUMAN",3871,"Q5T9P8","Q5T9P8_HUMAN",null,null,"PRPF18"]
["17.7566","18.6265","18.1313",1,{"$nulls":3},"enzyme-directed rRNA pseudouridine synthesis","pseudouridine synthase activity;RNA binding",{"$nulls":4},5,5,5,"14.1","14.1","14.1","61.311",0,10,53979000,9,"0.376286",1,"8.62587","1.00573","sp|Q8IZ73|RUSD2_HUMAN;tr|A0A087WXE2|A0A087WXE2_HUMAN","sp|Q8IZ73|RUSD2_HUMAN;tr|A0A087WXE2|A0A087WXE2_HUMAN",3175,"Q8IZ73","RUSD2_HUMAN","RNA pseudouridylate synthase domain-containing protein 2",null,"RPUSD2"]
["18.4521","18.5581","18.7763",1,{"$nulls":3},"COPII vesicle coating","Rab guanyl-nucleotide exchange factor activity","cytosol;endoplasmic reticulum;Golgi membrane;TRAPP complex",{"$nulls":3},1,1,1,"5.3","5.3","5.3","20.783","0.0035365","3.1637",42266000,5,"0.361929",1,"8.61697","0.969471","sp|Q8IUR0|TPPC5_HUMAN","sp|Q8IUR0|TPPC5_HUMAN",3106,"Q8IUR0","TPPC5_HUMAN","Trafficking protein particle complex subunit 5",null,"TRAPPC5"]
["18.2579","18.3908","18.4315",1,{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome","Ribosome",null,null,1,1,1,"5.3","5.3","5.3","21.514","0.0079875","2.3751",22136000,1,"0.369144",1,"8.6086","0.987679","sp|Q9NZE8|RM35_HUMAN","sp|Q9NZE8|RM35_HUMAN",4589,"Q9NZE8","RM35_HUMAN","39S ribosomal protein L35, mitochondrial","35mt;RP-L35","MRPL35"]
["19.1623","18.3222","19.2788",1,{"$nulls":3},"cellular response to glucose stimulus;cellular response to hypoxia;excitatory postsynaptic potential;lactation;nucleobase-containing compound metabolic process;nucleoside transport;sleep;uridine transport","nucleoside transmembrane transporter activity","apical plasma membrane;basolateral plasma membrane;integral component of plasma membrane;membrane;plasma membrane;postsynapse","Alcoholism",null,null,2,2,2,"6.4","6.4","6.4","50.219","0.00024254","5.7187",47359000,8,"0.350353",1,"8.60289","0.940305","sp|Q99808|S29A1_HUMAN","sp|Q99808|S29A1_HUMAN",3886,"Q99808","S29A1_HUMAN","Equilibrative nucleoside transporter 1",null,"SLC29A1"]
["17.3494","18.6112","17.7676",1,{"$nulls":3},"DNA-templated transcription, initiation;histone H3 acetylation;positive regulation of DNA binding transcription factor activity;regulation of signal transduction by p53 class mediator;RNA polymerase II transcriptional preinitiation complex assembly;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","DNA binding;protein heterodimerization activity;RNA polymerase II activating transcription factor binding;TBP-class protein binding;transcription coactivator activity;transcription factor binding","nucleoplasm;nucleus;PCAF complex;SAGA complex;STAGA complex;transcription factor TFIID complex;transcription factor TFTC complex","Basal transcription factors",null,null,2,2,2,13,13,13,"17.924","0.00024196","5.6657",100900000,13,"0.3829",1,"8.59648","1.02248","sp|Q16514|TAF12_HUMAN","sp|Q16514|TAF12_HUMAN",2544,"Q16514","TAF12_HUMAN","Transcription initiation factor TFIID subunit 12",null,"TAF12"]
["18.8046","17.7013","18.3345",1,{"$nulls":5},"cytoplasm;nuclear membrane;nucleolus;nucleus",{"$nulls":3},3,3,3,"40.3","40.3","40.3","16.014","0.00068997","4.609",28963000,4,"0.369504",1,"8.58569","0.988589","sp|Q9UK76|HN1_HUMAN;tr|J3KT51|J3KT51_HUMAN;tr|J3KSH8|J3KSH8_HUMAN","sp|Q9UK76|HN1_HUMAN;tr|J3KT51|J3KT51_HUMAN",4778,"Q9UK76","JUPI1_HUMAN","Jupiter microtubule associated homolog 1 {ECO:0000312|HGNC:HGNC:14569}",null,"JPT1"]
["17.8977","18.2264","17.9546",1,{"$nulls":3},"protein transport",null,"cytoplasm;cytosol;nuclear speck",{"$nulls":3},1,1,1,13,13,13,"34.593","0.0065269","2.5551",17807000,2,"0.378955",1,"8.58475","1.01249","sp|Q6PD74|AAGAB_HUMAN","sp|Q6PD74|AAGAB_HUMAN",2877,"Q6PD74","AAGAB_HUMAN","Alpha- and gamma-adaptin-binding protein p34",null,"AAGAB"]
["16.6547","17.5943",1,"16.1049",{"$nulls":3},"aging;ATP-dependent chromatin remodeling;brain development;embryonic organ development;heart development;histone acetylation;in utero embryonic development;methylation-dependent chromatin silencing;negative regulation of transcription from RNA polymerase II promoter;regulation of DNA methylation;regulation of signal transduction by p53 class mediator;response to estradiol;response to nutrient levels;tissue development;transcription, DNA-templated","chromatin binding;DNA binding;histone deacetylase activity;methyl-CpG binding","cytoplasm;heterochromatin;nuclear chromatin;nucleoplasm;NuRD complex;protein complex",{"$nulls":3},5,5,5,"16.8","16.8","16.8","32.844",0,"20.166",134350000,13,"0.426173",1,"8.57199","1.1328","sp|O95983|MBD3_HUMAN;tr|K7EIE8|K7EIE8_HUMAN;tr|A0A087WT34|A0A087WT34_HUMAN;tr|A0A087X1H1|A0A087X1H1_HUMAN;tr|A0A0A0MTS6|A0A0A0MTS6_HUMAN;tr|A0A087WZ12|A0A087WZ12_HUMAN","sp|O95983|MBD3_HUMAN;tr|K7EIE8|K7EIE8_HUMAN",781,"O95983","MBD3_HUMAN","Methyl-CpG-binding domain protein 3",null,"MBD3"]
["17.408","18.1249","17.389",1,{"$nulls":3},"chemotaxis;doxorubicin transport;drug transmembrane transport;endocytosis;positive regulation of GTPase activity;regulation of GTPase activity;regulation of small GTPase mediated signal transduction;signal transduction;small GTPase mediated signal transduction;transmembrane transport","ATPase activity, coupled to movement of substances;drug transmembrane transporter activity;GTPase activator activity;Rac GTPase binding;Ral GTPase binding;transmembrane transporter activity","cytosol;membrane","Pancreatic cancer;Pathways in cancer;Ras signaling pathway",null,null,8,8,8,18,18,18,"76.063",0,"24.393",247320000,43,"0.391802",1,"8.57193","1.04506","sp|Q15311|RBP1_HUMAN;tr|E7ENF8|E7ENF8_HUMAN;tr|J3QLT3|J3QLT3_HUMAN","sp|Q15311|RBP1_HUMAN;tr|E7ENF8|E7ENF8_HUMAN",2471,"Q15311","RBP1_HUMAN","RalA-binding protein 1","alBP1","RALBP1"]
["15.4421","18.1229","15.4628",1,{"$nulls":3},"histone H3-S28 phosphorylation;mitotic cell cycle;positive regulation of cytokinesis;spindle checkpoint","ATP binding;protein serine/threonine kinase activity","chromosome passenger complex;midbody;nucleoplasm",{"$nulls":3},4,4,4,"19.7","19.7","19.7","26.212",0,"8.8116",52265000,14,"0.43779",1,"8.5511","1.16269","tr|J3KTD6|J3KTD6_HUMAN;sp|Q96GD4|AURKB_HUMAN;tr|J3QR41|J3QR41_HUMAN;tr|J3QLN8|J3QLN8_HUMAN;tr|J3KRJ2|J3KRJ2_HUMAN;tr|J3KRF8|J3KRF8_HUMAN;tr|J3KT86|J3KT86_HUMAN;tr|B4DXA6|B4DXA6_HUMAN;tr|A3KFJ1|A3KFJ1_HUMAN;tr|Q5QPD4|Q5QPD4_HUMAN;tr|A0A0A0MSY3|A0A0A0MSY3_HUMAN;tr|Q5Y191|Q5Y191_HUMAN;sp|Q9UQB9|AURKC_HUMAN;tr|A3KFJ0|A3KFJ0_HUMAN;sp|O14965|AURKA_HUMAN","tr|J3KTD6|J3KTD6_HUMAN;sp|Q96GD4|AURKB_HUMAN;tr|J3QR41|J3QR41_HUMAN;tr|J3QLN8|J3QLN8_HUMAN;tr|J3KRJ2|J3KRJ2_HUMAN;tr|J3KRF8|J3KRF8_HUMAN;tr|J3KT86|J3KT86_HUMAN",3701,"J3KTD6","J3KTD6_HUMAN",null,null,"AURKB"]
["18.228","18.3398","18.473",1,{"$nulls":3},"cilium assembly;lipoprotein transport;neuron differentiation","lipid binding","ciliary transition zone;cilium;cytosol;intracellular",{"$nulls":3},2,2,2,"10.4","10.4","10.4","28.136","0.00024319","5.7589",45788000,7,"0.365444",1,"8.54741","0.978337","sp|A6NIH7|U119B_HUMAN;tr|K7EJU3|K7EJU3_HUMAN;tr|K7EN86|K7EN86_HUMAN;tr|C9JSK0|C9JSK0_HUMAN;sp|Q13432|U119A_HUMAN","sp|A6NIH7|U119B_HUMAN;tr|K7EJU3|K7EJU3_HUMAN;tr|K7EN86|K7EN86_HUMAN;tr|C9JSK0|C9JSK0_HUMAN;sp|Q13432|U119A_HUMAN",172,"A6NIH7","U119B_HUMAN","Protein unc-119 homolog B",null,"UNC119B"]
["20.2209","18.1509","20.2825",1,{"$nulls":3},"ceramide biosynthetic process;positive regulation of lipophagy;sphinganine biosynthetic process;sphingolipid biosynthetic process;sphingolipid metabolic process;sphingomyelin biosynthetic process;sphingosine biosynthetic process","pyridoxal phosphate binding;serine C-palmitoyltransferase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;serine C-palmitoyltransferase complex;SPOTS complex","Metabolic pathways;Sphingolipid metabolism;Sphingolipid signaling pathway",null,null,6,6,6,19,19,19,"52.743",0,"34.599",289180000,37,"0.326831",1,"8.54466","0.881197","sp|O15269|SPTC1_HUMAN","sp|O15269|SPTC1_HUMAN",347,"O15269","SPTC1_HUMAN","Serine palmitoyltransferase 1",null,"SPTLC1"]
["19.1524","18.8235","19.9014",1,{"$nulls":3},"metabolic process","uridylyltransferase activity",{"$nulls":4},11,1,1,59,"6.1","6.1","24.235","0.00046893","4.9826",51858000,4,"0.335599",1,"8.53727","0.903211","tr|C9JNZ1|C9JNZ1_HUMAN;tr|C9JVG3|C9JVG3_HUMAN;tr|C9JWG0|C9JWG0_HUMAN;tr|C9JTZ5|C9JTZ5_HUMAN;tr|C9JUW1|C9JUW1_HUMAN;tr|F2Z3H1|F2Z3H1_HUMAN;tr|C9J3M0|C9J3M0_HUMAN;tr|F2Z3P4|F2Z3P4_HUMAN;tr|F8WC70|F8WC70_HUMAN","tr|C9JNZ1|C9JNZ1_HUMAN;tr|C9JVG3|C9JVG3_HUMAN;tr|C9JWG0|C9JWG0_HUMAN;tr|C9JTZ5|C9JTZ5_HUMAN;tr|C9JUW1|C9JUW1_HUMAN",5186,"C9JNZ1","C9JNZ1_HUMAN",null,null,"UGP2"]
["19.363","18.675","19.9699",1,{"$nulls":3},"protein folding","unfolded protein binding","prefoldin complex",{"$nulls":3},2,2,2,"25.2","25.2","25.2","11.561","0.00025189","6.5129",45738000,5,"0.333984",1,"8.53404","0.899156","tr|A2AB88|A2AB88_HUMAN;sp|O15212|PFD6_HUMAN","tr|A2AB88|A2AB88_HUMAN;sp|O15212|PFD6_HUMAN",340,"A2AB88","A2AB88_HUMAN",null,null,"PFDN6"]
["16.8352","19.3114",1,"18.0916",{"$nulls":3},"signal transduction","protein phosphatase regulator activity","protein phosphatase type 2A complex",{"$nulls":3},3,3,3,29,29,29,"13.941",0,"8.2561",70511000,12,"0.369092",1,"8.52749","0.987549","tr|G3V292|G3V292_HUMAN;tr|H0YK26|H0YK26_HUMAN","tr|G3V292|G3V292_HUMAN;tr|H0YK26|H0YK26_HUMAN",5236,"G3V292","G3V292_HUMAN",null,null,"PPP2R5C"]
["18.3849","18.5419","18.8857",1,{"$nulls":9},2,2,2,"24.2","24.2","24.2","17.093","0.00066123","3.9758",43059000,8,"0.355292",1,"8.52056","0.952741","tr|M0R0H0|M0R0H0_HUMAN;sp|P55899|FCGRN_HUMAN;tr|M0R2T3|M0R2T3_HUMAN;tr|M0R0K7|M0R0K7_HUMAN;tr|M0QYM4|M0QYM4_HUMAN;tr|M0R220|M0R220_HUMAN;tr|M0QYN1|M0QYN1_HUMAN;tr|M0QYN9|M0QYN9_HUMAN;tr|M0R0A9|M0R0A9_HUMAN","tr|M0R0H0|M0R0H0_HUMAN;sp|P55899|FCGRN_HUMAN;tr|M0R2T3|M0R2T3_HUMAN;tr|M0R0K7|M0R0K7_HUMAN;tr|M0QYM4|M0QYM4_HUMAN;tr|M0R220|M0R220_HUMAN;tr|M0QYN1|M0QYN1_HUMAN;tr|M0QYN9|M0QYN9_HUMAN;tr|M0R0A9|M0R0A9_HUMAN",1774,"M0R0H0","M0R0H0_HUMAN",null,null,"FCGRT"]
["20.7673","17.9334","20.671",1,{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome","Ribosome",null,null,2,2,2,"12.2","12.2","12.2","21.405",0,"10.425",69383000,9,"0.317138",1,"8.51485","0.85688","sp|Q9BYC8|RM32_HUMAN","sp|Q9BYC8|RM32_HUMAN",4057,"Q9BYC8","RM32_HUMAN","39S ribosomal protein L32, mitochondrial","32mt;RP-L32","MRPL32"]
["18.0232","18.1094","18.1545",1,{"$nulls":3},"regulation of microtubule motor activity",{"$nulls":5},1,1,1,"11.7","11.7","11.7","14.077","0.0021249","3.4415",10958000,4,"0.369946",1,"8.48907","0.989705","tr|I3L2R3|I3L2R3_HUMAN;tr|I3L2T8|I3L2T8_HUMAN;tr|I3L533|I3L533_HUMAN;tr|I3L2R9|I3L2R9_HUMAN;tr|I3L522|I3L522_HUMAN;tr|X5DR54|X5DR54_HUMAN;sp|Q9NXR1|NDE1_HUMAN","tr|I3L2R3|I3L2R3_HUMAN;tr|I3L2T8|I3L2T8_HUMAN;tr|I3L533|I3L533_HUMAN;tr|I3L2R9|I3L2R9_HUMAN;tr|I3L522|I3L522_HUMAN;tr|X5DR54|X5DR54_HUMAN;sp|Q9NXR1|NDE1_HUMAN",4550,"I3L2R3","I3L2R3_HUMAN",null,null,"NDE1"]
["18.1043","19.6551","19.8381",1,{"$nulls":3},"protein complex assembly",null,"mitochondrion",{"$nulls":3},3,3,3,19,19,19,"19.91","0.00025536","6.8479",45527000,6,"0.332419",1,"8.46067","0.895224","tr|H0YEW4|H0YEW4_HUMAN;tr|A8MRA7|A8MRA7_HUMAN;sp|Q5TC12|ATPF1_HUMAN;tr|I3L448|I3L448_HUMAN;tr|H0YD21|H0YD21_HUMAN","tr|H0YEW4|H0YEW4_HUMAN;tr|A8MRA7|A8MRA7_HUMAN;sp|Q5TC12|ATPF1_HUMAN;tr|I3L448|I3L448_HUMAN",2740,"H0YEW4","H0YEW4_HUMAN",null,null,"ATPAF1"]
["16.5679","18.4466","17.0941",1,{"$nulls":3},"detoxification of nitrogen compound;nitrate metabolic process;oxidation-reduction process;xenobiotic metabolic process","molybdenum ion binding;molybdopterin cofactor binding;nitrate reductase activity;pyridoxal phosphate binding","extracellular exosome;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion;peroxisome",{"$nulls":3},4,4,4,"12.8","12.8","12.8","38.023","0.00067996","4.3566",113790000,3,"0.391482",1,"8.46018","1.04425","sp|Q969Z3|MARC2_HUMAN;tr|X1WI34|X1WI34_HUMAN;tr|F6V6Z1|F6V6Z1_HUMAN","sp|Q969Z3|MARC2_HUMAN;tr|X1WI34|X1WI34_HUMAN",3589,"Q969Z3","MARC2_HUMAN","Mitochondrial amidoxime reducing component 2","ARC2","MARC2"]
["18.0482","18.0534","18.1884",1,{"$nulls":5},"cytoplasm;plasma membrane",{"$nulls":3},3,3,3,"14.8","14.8","14.8","34.474","0.00024384","5.7924",29816000,9,"0.367681",1,"8.45658","0.983985","sp|Q96KN1|FA84B_HUMAN","sp|Q96KN1|FA84B_HUMAN",3758,"Q96KN1","FA84B_HUMAN","Protein FAM84B",null,"FAM84B"]
["19.0176","17.9105","19.0176",1,{"$nulls":3},"carbohydrate catabolic process;glycolipid catabolic process;glycoside catabolic process;glycosylceramide catabolic process;oligosaccharide metabolic process","alpha-galactosidase activity;alpha-N-acetylgalactosaminidase activity;protein homodimerization activity","cytoplasm;extracellular exosome;lysosome","Glycosphingolipid biosynthesis - globo and isoglobo series;Lysosome;Metabolic pathways",null,null,2,2,2,"7.5","7.5","7.5","46.564","0.00024201","5.666",42869000,9,"0.348956",1,"8.45525","0.936789","sp|P17050|NAGAB_HUMAN","sp|P17050|NAGAB_HUMAN",1093,"P17050","NAGAB_HUMAN","Alpha-N-acetylgalactosaminidase",null,"NAGA"]
["17.1723","19.6472",1,"18.9391",{"$nulls":3},"DNA damage response, detection of DNA damage;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;ribosomal small subunit assembly;translation","mRNA 5'-UTR binding;RNA binding;small ribosomal subunit rRNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion","Ribosome",null,null,4,4,4,"22.2","22.2","22.2","20.616",0,"12.075",160670000,43,"0.347113",1,"8.4402","0.932152","sp|P82912|RT11_HUMAN;tr|H0YL99|H0YL99_HUMAN","sp|P82912|RT11_HUMAN;tr|H0YL99|H0YL99_HUMAN",1994,"P82912","RT11_HUMAN","28S ribosomal protein S11, mitochondrial","11mt;RP-S11","MRPS11"]
["20.0446","15.5991","17.7767",1,{"$nulls":5},"GPI-anchor transamidase complex",{"$nulls":3},2,2,2,"10.3","10.3","10.3","26.076","0.00068807","4.5654",32522000,4,"0.362869",1,"8.43349","0.97184","tr|E9PLV6|E9PLV6_HUMAN;tr|E9PPZ9|E9PPZ9_HUMAN;sp|O43292|GPAA1_HUMAN;tr|E9PLG8|E9PLG8_HUMAN;tr|E9PM11|E9PM11_HUMAN","tr|E9PLV6|E9PLV6_HUMAN;tr|E9PPZ9|E9PPZ9_HUMAN;sp|O43292|GPAA1_HUMAN;tr|E9PLG8|E9PLG8_HUMAN;tr|E9PM11|E9PM11_HUMAN",388,"E9PLV6","E9PLV6_HUMAN",null,null,"GPAA1"]
["17.5202","17.6206","17.3043",1,{"$nulls":3},"DNA repair;oxidation-reduction process",{"$nulls":5},1,1,1,"13.4","13.4","13.4","12.055","0.0080094","2.4164",5222400,2,"0.386902",1,"8.41824","1.03262","tr|H0YJF3|H0YJF3_HUMAN;tr|G3V4M4|G3V4M4_HUMAN;sp|Q13686|ALKB1_HUMAN","tr|H0YJF3|H0YJF3_HUMAN;tr|G3V4M4|G3V4M4_HUMAN;sp|Q13686|ALKB1_HUMAN",2300,"H0YJF3","H0YJF3_HUMAN",null,null,"ALKBH1"]
["18.0927","18.9683","19.2315",1,{"$nulls":3},"negative regulation of gluconeogenesis",null,"nucleoplasm",{"$nulls":3},2,2,2,"7.7","7.7","7.7","30.402",0,"11.612",48643000,5,"0.343093",1,"8.4148","0.922043","tr|D6REW7|D6REW7_HUMAN;tr|B4DQT1|B4DQT1_HUMAN;tr|B4DVN3|B4DVN3_HUMAN;sp|Q7L5Y9|MAEA_HUMAN;tr|E7ESC7|E7ESC7_HUMAN;tr|D6RID6|D6RID6_HUMAN;tr|D6RE80|D6RE80_HUMAN;tr|D6RDW4|D6RDW4_HUMAN;tr|D6RIB6|D6RIB6_HUMAN","tr|D6REW7|D6REW7_HUMAN;tr|B4DQT1|B4DQT1_HUMAN;tr|B4DVN3|B4DVN3_HUMAN;sp|Q7L5Y9|MAEA_HUMAN;tr|E7ESC7|E7ESC7_HUMAN;tr|D6RID6|D6RID6_HUMAN;tr|D6RE80|D6RE80_HUMAN;tr|D6RDW4|D6RDW4_HUMAN;tr|D6RIB6|D6RIB6_HUMAN",2973,"D6REW7","D6REW7_HUMAN",null,null,"MAEA"]
["16.1345","16.764",1,"15.1052",{"$nulls":3},"fat cell differentiation;skeletal muscle tissue development","histone acetyltransferase activity;methyltransferase activity","cytoplasm;nucleus",{"$nulls":3},3,3,3,"11.3","11.3","11.3","46.992","0.00025543","6.8531",99756000,11,"0.448127",1,"8.39665","1.18939","tr|B3KW44|B3KW44_HUMAN;tr|B5ME25|B5ME25_HUMAN;sp|Q9H825|METL8_HUMAN;tr|E7ETE0|E7ETE0_HUMAN;tr|C9JE69|C9JE69_HUMAN","tr|B3KW44|B3KW44_HUMAN;tr|B5ME25|B5ME25_HUMAN;sp|Q9H825|METL8_HUMAN;tr|E7ETE0|E7ETE0_HUMAN",5172,"B3KW44","B3KW44_HUMAN",null,null,"METTL8"]
["16.6806","17.6661",1,"16.5683",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity;nuclear retention of pre-mRNA at the site of transcription;poly(A)+ mRNA export from nucleus;positive regulation of B cell differentiation;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of transcription, DNA-templated;posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery;regulation of mRNA stability;spleen development;transcription elongation from RNA polymerase II promoter","double-stranded DNA binding;RNA binding","transcription export complex 2",{"$nulls":3},4,4,4,"13.5","13.5","13.5","46.029",0,"13.535",135190000,16,"0.403796",1,"8.38917","1.07557","sp|Q5JVF3|PCID2_HUMAN","sp|Q5JVF3|PCID2_HUMAN",2704,"Q5JVF3","PCID2_HUMAN","PCI domain-containing protein 2",null,"PCID2"]
["17.2504","17.3028","16.7926",1,{"$nulls":5},"cytosol;integral component of membrane;nucleus",{"$nulls":3},11,11,11,"26.3","26.3","26.3","75.532",0,"38.133",316520000,41,"0.398188",1,"8.38032","1.06129","sp|Q9Y426|CU025_HUMAN;tr|H7BZB0|H7BZB0_HUMAN","sp|Q9Y426|CU025_HUMAN",5002,"Q9Y426","C2CD2_HUMAN","C2 domain-containing protein 2",null,"C2CD2"]
["18.4065","17.8662","18.5128",1,{"$nulls":3},"cellular protein metabolic process;negative regulation of amyloid precursor protein biosynthetic process;nervous system development","amyloid-beta binding;ATP binding","endosome membrane;extracellular exosome;extracellular region;extracellular space;Golgi apparatus;Golgi membrane;Golgi-associated vesicle membrane;integral component of organelle membrane;intracellular membrane-bounded organelle;membrane;plasma membrane",{"$nulls":3},1,1,1,"3.8","3.8","3.8","30.338","0.0037022","3.0016",29081000,7,"0.356803",1,"8.37991","0.956547","sp|Q9Y287|ITM2B_HUMAN","sp|Q9Y287|ITM2B_HUMAN",4904,"Q9Y287","ITM2B_HUMAN","Integral membrane protein 2B",null,"ITM2B"]
["19.6223","17.7126","19.6083",1,{"$nulls":4},"RNA binding",{"$nulls":4},4,4,4,"40.4","40.4","40.4","12.614",0,"8.2779",61689000,5,"0.332005",1,"8.36332","0.894185","tr|H0YIB4|H0YIB4_HUMAN;sp|Q13242|SRSF9_HUMAN;tr|S4R3G0|S4R3G0_HUMAN","tr|H0YIB4|H0YIB4_HUMAN;sp|Q13242|SRSF9_HUMAN;tr|S4R3G0|S4R3G0_HUMAN",2225,"H0YIB4","H0YIB4_HUMAN",null,null,"SRSF9"]
["19.7477","18.367","20.4338",1,{"$nulls":3},"protein import into mitochondrial inner membrane",null,"integral component of membrane;mitochondrial inner membrane;mitochondrial inner membrane protein insertion complex;mitochondrial intermembrane space",{"$nulls":3},3,3,3,"17.3","17.3","17.3","29.233",0,"18.645",212500000,20,"0.316861",1,"8.34045","0.856187","sp|Q9BSF4|CS052_HUMAN","sp|Q9BSF4|CS052_HUMAN",3948,"Q9BSF4","TIM29_HUMAN","Mitochondrial import inner membrane translocase subunit Tim29 {ECO:0000303|PubMed:27554484}","IM29 {ECO:0000303|PubMed:27554484}","TIMM29"]
["17.7086","18.122",1,"18.1643",{"$nulls":3},"7-methylguanosine mRNA capping;androgen receptor signaling pathway;cell cycle arrest;cell division;cell proliferation;G1/S transition of mitotic cell cycle;G2/M transition of mitotic cell cycle;nucleotide-excision repair, preincision complex assembly;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;protein stabilization;regulation of cyclin-dependent protein serine/threonine kinase activity;snRNA transcription from RNA polymerase II promoter;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair","androgen receptor binding;ATP binding;cyclin-dependent protein serine/threonine kinase activity;DNA-dependent ATPase activity;kinase activity;protein C-terminus binding;protein kinase activity;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity;transcription coactivator activity","cyclin-dependent protein kinase activating kinase holoenzyme complex;cytoplasm;holo TFIIH complex;nucleoplasm;nucleus;perinuclear region of cytoplasm;TFIIK complex","Basal transcription factors;Cell cycle;Nucleotide excision repair",null,null,10,10,10,"31.5","31.5","31.5","39.038",0,"21.097",375610000,54,"0.362419",1,"8.33315","0.970706","sp|P50613|CDK7_HUMAN;tr|D6RAD4|D6RAD4_HUMAN;tr|D6R9G1|D6R9G1_HUMAN;tr|D6REC6|D6REC6_HUMAN;tr|D6RFL0|D6RFL0_HUMAN;tr|D6RGG9|D6RGG9_HUMAN;tr|D6RI01|D6RI01_HUMAN;tr|D6R9Z2|D6R9Z2_HUMAN;tr|D6RF14|D6RF14_HUMAN;tr|D6RIG9|D6RIG9_HUMAN;tr|A0A0D9SFW9|A0A0D9SFW9_HUMAN;sp|Q9C098|DCLK3_HUMAN","sp|P50613|CDK7_HUMAN;tr|D6RAD4|D6RAD4_HUMAN;tr|D6R9G1|D6R9G1_HUMAN;tr|D6REC6|D6REC6_HUMAN",1633,"P50613","CDK7_HUMAN","Cyclin-dependent kinase 7",null,"CDK7"]
["18.3546","18.3602","19.1078",1,{"$nulls":3},"multicellular organism development;positive regulation of transcription, DNA-templated","zinc ion binding",{"$nulls":4},1,1,1,"15.3","15.3","15.3","9.8242","0.0065217","2.5417",17656000,4,"0.341134",1,"8.3035","0.917118","tr|H0YIM9|H0YIM9_HUMAN;tr|A0A0C4DGJ7|A0A0C4DGJ7_HUMAN;sp|Q8WUH1|CHUR_HUMAN","tr|H0YIM9|H0YIM9_HUMAN;tr|A0A0C4DGJ7|A0A0C4DGJ7_HUMAN;sp|Q8WUH1|CHUR_HUMAN",3420,"H0YIM9","H0YIM9_HUMAN",null,null,"CHURC1-FNTB"]
["18.2644","17.3516","18.0348",1,{"$nulls":4},"dioxygenase activity;iron ion binding;L-ascorbic acid binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen","extracellular exosome;integral component of membrane;membrane",{"$nulls":3},4,4,4,"16.6","16.6","16.6","35.646","0.00026233","7.3867",103990000,12,"0.362924",1,"8.29061","0.971981","sp|Q6PK18|OGFD3_HUMAN;tr|K7ENS7|K7ENS7_HUMAN;tr|J3QRG1|J3QRG1_HUMAN","sp|Q6PK18|OGFD3_HUMAN;tr|K7ENS7|K7ENS7_HUMAN;tr|J3QRG1|J3QRG1_HUMAN",2887,"Q6PK18","OGFD3_HUMAN","2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3",null,"OGFOD3"]
["17.7715","17.7663","17.9636",1,{"$nulls":3},"transcription, DNA-templated","DNA binding transcription factor activity;sequence-specific DNA binding","nucleus",{"$nulls":3},4,4,4,14,14,14,"63.217","0.0025157","3.2863",22287000,4,"0.364931",1,"8.28709","0.977044","tr|G5E965|G5E965_HUMAN;tr|C9J0F0|C9J0F0_HUMAN;sp|Q9H334|FOXP1_HUMAN;tr|A0A087X299|A0A087X299_HUMAN;tr|E9PFD3|E9PFD3_HUMAN;tr|A0A087WVT2|A0A087WVT2_HUMAN;tr|H0Y882|H0Y882_HUMAN;tr|A0A0B4J2F3|A0A0B4J2F3_HUMAN;tr|C9IYY1|C9IYY1_HUMAN;tr|A0A087X2G3|A0A087X2G3_HUMAN;tr|C9J5T4|C9J5T4_HUMAN","tr|G5E965|G5E965_HUMAN;tr|C9J0F0|C9J0F0_HUMAN;sp|Q9H334|FOXP1_HUMAN;tr|A0A087X299|A0A087X299_HUMAN;tr|E9PFD3|E9PFD3_HUMAN;tr|A0A087WVT2|A0A087WVT2_HUMAN;tr|H0Y882|H0Y882_HUMAN;tr|A0A0B4J2F3|A0A0B4J2F3_HUMAN",4184,"G5E965","G5E965_HUMAN"]
["17.8913","18.0161",1,"18.3351",{"$nulls":9},1,1,1,"14.9","14.9","14.9","13.152","0.0037083","3.0405",36199000,13,"0.356573",1,"8.28613","0.955968","tr|F2Z2B6|F2Z2B6_HUMAN;tr|F2Z3N8|F2Z3N8_HUMAN;sp|Q92613|JADE3_HUMAN","tr|F2Z2B6|F2Z2B6_HUMAN;tr|F2Z3N8|F2Z3N8_HUMAN;sp|Q92613|JADE3_HUMAN",3506,"F2Z2B6","F2Z2B6_HUMAN",null,null,"JADE3"]
["18.0424","17.5238","17.9965",1,{"$nulls":3},"electron transport chain;hydrogen ion transmembrane transport",null,"mitochondrial respiratory chain complex IV;nucleus",{"$nulls":3},2,2,2,"30.1","30.1","30.1","9.6172","0.0090576","2.257",5755300,2,"0.363901",1,"8.28491","0.974445","sp|Q9C002|NMES1_HUMAN;tr|H0YKW5|H0YKW5_HUMAN","sp|Q9C002|NMES1_HUMAN;tr|H0YKW5|H0YKW5_HUMAN",4090,"Q9C002","NMES1_HUMAN","Normal mucosa of esophagus-specific gene 1 protein",null,"NMES1"]
["16.9396","16.9424",1,"16.3351",{"$nulls":5},"nucleus",{"$nulls":3},16,14,14,"35.3","29.9","29.9","77.319",0,"98.325",773160000,68,"0.405147",1,"8.27343","1.07902","tr|A0A0C4DGT8|A0A0C4DGT8_HUMAN;tr|A0A087WWP8|A0A087WWP8_HUMAN;sp|Q5VWQ0|RSBN1_HUMAN;tr|A0A0C4DH79|A0A0C4DH79_HUMAN","tr|A0A0C4DGT8|A0A0C4DGT8_HUMAN;tr|A0A087WWP8|A0A087WWP8_HUMAN;sp|Q5VWQ0|RSBN1_HUMAN",2764,"A0A0C4DGT8","A0A0C4DGT8_HUMAN",null,null,"RSBN1"]
["17.4032","16.0267",1,"15.8954",{"$nulls":3},"positive regulation of epithelial cell migration;self proteolysis","calcium-dependent cysteine-type endopeptidase activity;endopeptidase activity;MIT domain binding","cytoplasm;cytosol;extracellular exosome;nuclear body;nucleoplasm",{"$nulls":3},3,3,3,"3.8","3.8","3.8","92.651","0.0013007","3.7236",33910000,6,"0.415452",1,"8.26725","1.10533","sp|Q9Y6W3|CAN7_HUMAN","sp|Q9Y6W3|CAN7_HUMAN",5116,"Q9Y6W3","CAN7_HUMAN","Calpain-7",null,"CAPN7"]
["17.0329","17.9078","17.4122",1,{"$nulls":9},2,2,2,"12.9","12.9","12.9","23.011","0.00066196","3.9882",35788000,7,"0.376258",1,"8.26429","1.00566","tr|K7EJX8|K7EJX8_HUMAN;sp|Q96G46|DUS3L_HUMAN","tr|K7EJX8|K7EJX8_HUMAN;sp|Q96G46|DUS3L_HUMAN",3694,"K7EJX8","K7EJX8_HUMAN",null,null,"DUS3L"]
["17.5211","19.3605",1,"19.3753",{"$nulls":3},"peroxisome membrane biogenesis;peroxisome organization;protein import into peroxisome membrane;transmembrane transport","lipid binding;protein dimerization activity","cytosol;endoplasmic reticulum;integral component of peroxisomal membrane;membrane;nucleoplasm;peroxisomal membrane;peroxisome;protein complex;protein-lipid complex","Peroxisome",null,null,3,3,3,"12.1","12.1","12.1","42.139",0,"46.813",149820000,16,"0.331857",1,"8.25312","0.893815","sp|P56589|PEX3_HUMAN;tr|Q7Z6V3|Q7Z6V3_HUMAN","sp|P56589|PEX3_HUMAN",1787,"P56589","PEX3_HUMAN","Peroxisomal biogenesis factor 3",null,"PEX3"]
["16.4499","15.6271","14.5743",1,{"$nulls":3},"protein transport","metal ion binding","early endosome membrane;endoplasmic reticulum;transport vesicle",{"$nulls":3},4,4,4,"16.9","16.9","16.9","27.797",0,"13.201",149990000,15,"0.457423",1,"8.25135","1.2135","sp|Q9H8W4|PKHF2_HUMAN","sp|Q9H8W4|PKHF2_HUMAN",4261,"Q9H8W4","PKHF2_HUMAN","Pleckstrin homology domain-containing family F member 2","H domain-containing family F member 2","PLEKHF2"]
["18.0526","17.4181","18.0279",1,{"$nulls":4},"hydrolase activity",{"$nulls":4},1,1,1,"5.9","5.9","5.9","25.029","0.0038958","2.9563",9938200,2,"0.360145",1,"8.22141","0.964972","tr|F5GXT0|F5GXT0_HUMAN;tr|F8W7U8|F8W7U8_HUMAN;sp|P49959|MRE11_HUMAN","tr|F5GXT0|F5GXT0_HUMAN;tr|F8W7U8|F8W7U8_HUMAN;sp|P49959|MRE11_HUMAN",1615,"F5GXT0","F5GXT0_HUMAN",null,null,"MRE11"]
["17.6801","17.0536","17.2957",1,{"$nulls":9},2,2,2,"9.6","9.6","9.6","34.736","0.007451","2.4603",9109500,2,"0.377176",1,"8.21897","1.00798","tr|J3QLH0|J3QLH0_HUMAN;tr|J3QL54|J3QL54_HUMAN;tr|J3KT10|J3KT10_HUMAN;sp|Q9BW27|NUP85_HUMAN;tr|J3QLV0|J3QLV0_HUMAN;tr|F5H0W7|F5H0W7_HUMAN;tr|J3QLD4|J3QLD4_HUMAN","tr|J3QLH0|J3QLH0_HUMAN;tr|J3QL54|J3QL54_HUMAN;tr|J3KT10|J3KT10_HUMAN;sp|Q9BW27|NUP85_HUMAN;tr|J3QLV0|J3QLV0_HUMAN;tr|F5H0W7|F5H0W7_HUMAN;tr|J3QLD4|J3QLD4_HUMAN",4021,"J3QLH0","J3QLH0_HUMAN",null,null,"NUP85"]
["17.1598","17.3572","17.0821",1,{"$nulls":3},"defense response to virus;JAK-STAT cascade;regulation of mitochondrial fission;regulation of protein phosphorylation;regulation of transcription from RNA polymerase II promoter;regulation of type I interferon-mediated signaling pathway;transcription, DNA-templated;type I interferon signaling pathway;viral process","DNA binding;DNA binding transcription factor activity;identical protein binding;signal transducer activity;ubiquitin-like protein ligase binding","cytosol;nucleoplasm;plasma membrane","Chemokine signaling pathway;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human papillomavirus infection;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pathways in cancer",null,null,2,2,2,"4.3","4.3","4.3","97.915","0.00069557","4.8024",40591000,8,"0.382655",1,"8.21743","1.02186","sp|P52630|STAT2_HUMAN;tr|B4DLC8|B4DLC8_HUMAN","sp|P52630|STAT2_HUMAN;tr|B4DLC8|B4DLC8_HUMAN",1690,"P52630","STAT2_HUMAN","Signal transducer and activator of transcription 2",null,"STAT2"]
["19.372","17.685","19.6391",1,{"$nulls":9},7,7,7,"18.5","18.5","18.5","62.167",0,"10.867",123640000,14,"0.325255",1,"8.20893","0.877242","tr|F6VX93|F6VX93_HUMAN;sp|Q5VIR6|VPS53_HUMAN;tr|I3L184|I3L184_HUMAN;tr|E7EVT8|E7EVT8_HUMAN;tr|I3L0S6|I3L0S6_HUMAN","tr|F6VX93|F6VX93_HUMAN;sp|Q5VIR6|VPS53_HUMAN",2752,"F6VX93","F6VX93_HUMAN",null,null,"VPS53"]
["16.6632","18.85","18.1146",1,{"$nulls":3},"enzyme active site formation via cysteine modification to L-cysteine persulfide;molybdopterin cofactor biosynthetic process;Mo-molybdopterin cofactor biosynthetic process;protein urmylation;tRNA thio-modification;tRNA wobble position uridine thiolation;tRNA wobble uridine modification","ATP binding;metal ion binding;molybdopterin-synthase adenylyltransferase activity;molybdopterin-synthase sulfurtransferase activity;nucleotidyltransferase activity;sulfurtransferase activity;thiosulfate sulfurtransferase activity;URM1 activating enzyme activity","cytosol","Sulfur relay system",null,null,2,2,2,"8.5","8.5","8.5","49.669",0,"12.72",28974000,3,"0.354378",1,"8.19931","0.95044","sp|O95396|MOCS3_HUMAN","sp|O95396|MOCS3_HUMAN",729,"O95396","MOCS3_HUMAN","Adenylyltransferase and sulfurtransferase MOCS3 {ECO:0000255|HAMAP-Rule:MF_03049}",null,"MOCS3"]
["17.9148","16.5747",1,"17.1051",{"$nulls":3},"'de novo' pyrimidine nucleobase biosynthetic process;'de novo' UMP biosynthetic process;female pregnancy;lactation;positive regulation of apoptotic process;pyrimidine nucleoside biosynthetic process;regulation of mitochondrial fission;response to caffeine;response to drug;response to L-arginine;response to starvation","dihydroorotate dehydrogenase activity;drug binding;FMN binding;ubiquinone binding","cytosol;integral component of membrane;mitochondrial inner membrane;mitochondrion;neuronal cell body;nucleoplasm","Metabolic pathways;Pyrimidine metabolism",null,null,2,2,2,"8.1","8.1","8.1","42.867",0,"13.436",33079000,7,"0.379487",1,"8.19217","1.01383","sp|Q02127|PYRD_HUMAN;tr|I3NI32|I3NI32_HUMAN","sp|Q02127|PYRD_HUMAN;tr|I3NI32|I3NI32_HUMAN",2062,"Q02127","PYRD_HUMAN","Dihydroorotate dehydrogenase (quinone), mitochondrial","HOdehase","DHODH"]
["18.1437","17.6796","18.442",1,{"$nulls":3},"cellular response to DNA damage stimulus;cellular response to ionizing radiation;DNA damage checkpoint;DNA repair;DNA replication;double-strand break repair via homologous recombination;embryo development;intra-S DNA damage checkpoint;meiotic DNA integrity checkpoint;mitotic DNA replication checkpoint;negative regulation of DNA replication;nucleotide-excision repair;protein phosphorylation;regulation of protein phosphorylation;regulation of signal transduction by p53 class mediator;response to UV",null,"checkpoint clamp complex;cytosol;nucleolus;nucleoplasm;nucleus;site of double-strand break","Cellular senescence",null,null,1,1,1,5,5,5,"31.691","0.0048711","2.8304",22314000,3,"0.349777",1,"8.19066","0.938855","sp|O60921|HUS1_HUMAN","sp|O60921|HUS1_HUMAN",514,"O60921","HUS1_HUMAN","Checkpoint protein HUS1","HUS1","HUS1"]
["18.854","17.7296",1,"19.2102",{"$nulls":9},3,3,3,"15.2","15.2","15.2","34.647","0.00023838","5.3802",38314000,4,"0.333296",1,"8.18672","0.897427","tr|Q5T063|Q5T063_HUMAN;sp|Q9NZJ6|COQ3_HUMAN;tr|F6WGP0|F6WGP0_HUMAN","tr|Q5T063|Q5T063_HUMAN;sp|Q9NZJ6|COQ3_HUMAN",4592,"Q5T063"]
["18.1986","18.1152","18.9433",1,{"$nulls":3},"mRNA processing","RNA binding","nucleus",{"$nulls":3},3,2,2,"7.1","5.7","5.7","56.45",0,"10.101",77968000,5,"0.339233",1,"8.18529","0.912341","tr|B7WPG3|B7WPG3_HUMAN;tr|C9IYN3|C9IYN3_HUMAN;tr|D6W592|D6W592_HUMAN;sp|Q8WVV9|HNRLL_HUMAN;tr|H7C464|H7C464_HUMAN;tr|C9JJZ7|C9JJZ7_HUMAN;tr|H7BXH8|H7BXH8_HUMAN","tr|B7WPG3|B7WPG3_HUMAN;tr|C9IYN3|C9IYN3_HUMAN;tr|D6W592|D6W592_HUMAN;sp|Q8WVV9|HNRLL_HUMAN;tr|H7C464|H7C464_HUMAN",3446,"B7WPG3","B7WPG3_HUMAN",null,null,"HNRNPLL"]
["16.6802","16.8562","16.1783",1,{"$nulls":3},"mitotic metaphase plate congression;negative regulation of cell proliferation;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of protein ubiquitination;negative regulation of telomerase activity;negative regulation of telomere maintenance via telomerase;negative regulation of telomere maintenance via telomere lengthening;positive regulation of protein localization to nucleolus;positive regulation of telomeric DNA binding;protein localization to chromosome, telomeric region;protein localization to nucleolus;regulation of protein stability;regulation of telomerase activity;telomere maintenance via telomerase","macromolecular complex binding;telomerase inhibitor activity;telomerase RNA binding","chromosome, telomeric region;condensed chromosome kinetochore;kinetochore;nuclear chromosome;nuclear chromosome, telomeric region;nucleolus;spindle",{"$nulls":3},4,4,4,"16.8","16.8","16.8","37.034",0,"13.611",120920000,16,"0.404614",1,"8.17904","1.07765","sp|Q96BK5|PINX1_HUMAN;tr|E5RJG9|E5RJG9_HUMAN;tr|E5RGR1|E5RGR1_HUMAN;tr|A0A0A6YYK5|A0A0A6YYK5_HUMAN","sp|Q96BK5|PINX1_HUMAN;tr|E5RJG9|E5RJG9_HUMAN;tr|E5RGR1|E5RGR1_HUMAN;tr|A0A0A6YYK5|A0A0A6YYK5_HUMAN",3613,"Q96BK5","PINX1_HUMAN","PIN2/TERF1-interacting telomerase inhibitor 1",null,"PINX1"]
["17.2562","17.5508",1,"17.464",{"$nulls":3},"base-excision repair, gap-filling;cellular response to UV;DNA damage response, detection of DNA damage;DNA ligation;DNA repair;DNA replication;DNA replication proofreading;DNA synthesis involved in DNA repair;fatty acid homeostasis;mismatch repair;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;response to UV;telomere maintenance;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","3'-5'-exodeoxyribonuclease activity;4 iron, 4 sulfur cluster binding;chromatin binding;damaged DNA binding;DNA binding;DNA-directed DNA polymerase activity;metal ion binding;nucleotide binding","aggresome;cytosol;delta DNA polymerase complex;membrane;nucleoplasm;nucleotide-excision repair complex;nucleus","Base excision repair;DNA replication;Homologous recombination;Mismatch repair;Nucleotide excision repair",null,null,12,12,12,"14.3","14.3","14.3","123.63",0,"30.138",221310000,37,"0.371047",1,"8.17148","0.992487","sp|P28340|DPOD1_HUMAN;tr|M0R2B7|M0R2B7_HUMAN;tr|M0QZR8|M0QZR8_HUMAN;tr|M0QZB4|M0QZB4_HUMAN;tr|M0R2I8|M0R2I8_HUMAN;tr|M0QXE6|M0QXE6_HUMAN;tr|M0R3H8|M0R3H8_HUMAN","sp|P28340|DPOD1_HUMAN;tr|M0R2B7|M0R2B7_HUMAN;tr|M0QZR8|M0QZR8_HUMAN",1270,"P28340","DPOD1_HUMAN","DNA polymerase delta catalytic subunit",null,"POLD1"]
["20.3051","17.5199","20.4848",1,{"$nulls":3},"autophagy;cell junction assembly;cell-cell adhesion;embryo implantation;endoplasmic reticulum organization;exocytosis;Golgi organization",null,"autophagosome membrane;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment membrane;integral component of membrane;membrane;nucleolus;phagophore assembly site;plasma membrane","Autophagy - animal",null,null,3,3,3,"13.8","13.8","13.8","46.237",0,"8.5104",86051000,3,"0.306485",1,"8.17008","0.830171","sp|Q96GC9|VMP1_HUMAN;tr|K7EPE7|K7EPE7_HUMAN;tr|K7EL93|K7EL93_HUMAN;tr|K7EL74|K7EL74_HUMAN;tr|K7ENU2|K7ENU2_HUMAN;tr|K7EK01|K7EK01_HUMAN;tr|K7EMI0|K7EMI0_HUMAN;tr|K7ELS2|K7ELS2_HUMAN","sp|Q96GC9|VMP1_HUMAN;tr|K7EPE7|K7EPE7_HUMAN",3699,"Q96GC9","VMP1_HUMAN","Vacuole membrane protein 1",null,"VMP1"]
["18.4195","17.6249","18.7082",1,{"$nulls":3},"nucleotide-excision repair","damaged DNA binding","nucleus",{"$nulls":3},2,2,2,"12.9","12.9","12.9","30.032","0.00023546","5.1103",15437000,4,"0.342912",1,"8.16807","0.921589","tr|F2Z2T2|F2Z2T2_HUMAN;sp|P23025|XPA_HUMAN","tr|F2Z2T2|F2Z2T2_HUMAN;sp|P23025|XPA_HUMAN",1189,"F2Z2T2","F2Z2T2_HUMAN",null,null,"XPA"]
["17.4331","17.7951",1,"17.9792",{"$nulls":4},"ATP binding;MAP kinase kinase kinase activity","cytosol",{"$nulls":3},2,1,1,"7.5","3.5","3.5","51.582","0.0002454","5.9034",13777000,3,"0.356894",1,"8.12451","0.956779","tr|D4Q8H0|D4Q8H0_HUMAN","tr|D4Q8H0|D4Q8H0_HUMAN",5190,"D4Q8H0","D4Q8H0_HUMAN",null,null,"pk"]
["16.9456","16.9647","16.6855",1,{"$nulls":3},"DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;nuclear-transcribed mRNA poly(A) tail shortening;protein autoubiquitination","metal ion binding;RNA binding;ubiquitin-protein transferase activity","cytosol;nucleus","RNA degradation",null,null,3,3,3,"8.9","8.9","8.9","63.509","0.0085271","2.3173",18856000,6,"0.387593",1,"8.11236","1.03438","sp|O95628|CNOT4_HUMAN","sp|O95628|CNOT4_HUMAN",749,"O95628","CNOT4_HUMAN","CCR4-NOT transcription complex subunit 4",null,"CNOT4"]
["19.0616","17.4388","19.2779",1,{"$nulls":4},"RNA binding",{"$nulls":4},9,1,1,"66.4","8.6","8.6","24.043","0.00088028","3.9491",55884000,15,"0.327978",1,"8.1113","0.884077","tr|C9JSZ1|C9JSZ1_HUMAN","tr|C9JSZ1|C9JSZ1_HUMAN",5187,"C9JSZ1","C9JSZ1_HUMAN",null,null,"FUBP1"]
["17.1802","16.4765",1,"16.4401",{"$nulls":3},"adaptive immune response;B cell homeostasis;B cell receptor signaling pathway;blood coagulation;cellular response to DNA damage stimulus;cellular response to extracellular stimulus;cellular response to heat;cellular response to retinoic acid;central nervous system development;cytokine secretion;dendritic cell differentiation;ephrin receptor signaling pathway;erythrocyte differentiation;Fc receptor mediated inhibitory signaling pathway;Fc receptor mediated stimulatory signaling pathway;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;histamine secretion by mast cell;immune response-regulating cell surface receptor signaling pathway;inflammatory response;innate immune response;JAK-STAT cascade involved in growth hormone signaling pathway;leukocyte migration;lipopolysaccharide-mediated signaling pathway;negative regulation of B cell proliferation;negative regulation of cell proliferation;negative regulation of ERK1 and ERK2 cascade;negative regulation of immune response;negative regulation of intracellular signal transduction;negative regulation of MAP kinase activity;negative regulation of mast cell proliferation;negative regulation of myeloid leukocyte differentiation;negative regulation of protein phosphorylation;negative regulation of toll-like receptor 2 signaling pathway;negative regulation of toll-like receptor 4 signaling pathway;neuron projection development;oligodendrocyte development;peptidyl-tyrosine autophosphorylation;peptidyl-tyrosine phosphorylation;platelet activation;platelet degranulation;positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;positive regulation of B cell receptor signaling pathway;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of cellular component movement;positive regulation of dendritic cell apoptotic process;positive regulation of Fc receptor mediated stimulatory signaling pathway;positive regulation of glial cell proliferation;positive regulation of mast cell proliferation;positive regulation of neuron projection development;positive regulation of oligodendrocyte progenitor proliferation;positive regulation of phosphatidylinositol 3-kinase activity;positive regulation of protein phosphorylation;positive regulation of stress-activated protein kinase signaling cascade;positive regulation of tyrosine phosphorylation of STAT protein;protein autophosphorylation;protein phosphorylation;regulation of B cell apoptotic process;regulation of B cell receptor signaling pathway;regulation of cell adhesion mediated by integrin;regulation of cytokine production;regulation of cytokine secretion;regulation of ERK1 and ERK2 cascade;regulation of erythrocyte differentiation;regulation of inflammatory response;regulation of mast cell activation;regulation of mast cell degranulation;regulation of monocyte chemotaxis;regulation of platelet aggregation;regulation of protein phosphorylation;regulation of release of sequestered calcium ion into cytosol;response to amino acid;response to axon injury;response to carbohydrate;response to drug;response to hormone;response to insulin;response to organic cyclic compound;response to sterol depletion;response to toxic substance;signal transduction;stimulatory C-type lectin receptor signaling pathway;T cell costimulation;tolerance induction to self antigen;transmembrane receptor protein tyrosine kinase signaling pathway;viral process","ATP binding;enzyme binding;ephrin receptor binding;gamma-tubulin binding;glycosphingolipid binding;integrin binding;ion channel binding;kinase activity;non-membrane spanning protein tyrosine kinase activity;phosphoprotein binding;phosphorylation-dependent protein binding;platelet-derived growth factor receptor binding;protein tyrosine kinase activity;receptor binding;SH3 domain binding;signal transducer, downstream of receptor, with protein tyrosine kinase activity;ubiquitin protein ligase binding","cell-cell adherens junction;cytoplasm;cytosol;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane;Golgi apparatus;integrin alpha2-beta1 complex;intracellular membrane-bounded organelle;mast cell granule;membrane raft;mitochondrial crista;mitochondrial intermembrane space;nucleus;perinuclear region of cytoplasm;plasma membrane;postsynaptic density","B cell receptor signaling pathway;Chemokine signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;NF-kappa B signaling pathway;Platelet activation;Viral carcinogenesis",null,null,1,1,1,2,2,2,"58.573","0.0037252","3.1039",38486000,7,"0.393434",1,"8.10831","1.0492","sp|P07948|LYN_HUMAN;tr|H0Y3C5|H0Y3C5_HUMAN;tr|J3KPD6|J3KPD6_HUMAN;sp|P08631|HCK_HUMAN","sp|P07948|LYN_HUMAN;tr|H0Y3C5|H0Y3C5_HUMAN;tr|J3KPD6|J3KPD6_HUMAN;sp|P08631|HCK_HUMAN",909,"P07948","LYN_HUMAN","Tyrosine-protein kinase Lyn",null,"LYN"]
["17.1887","17.5831","17.6021",1,{"$nulls":3},"galactose catabolic process;galactose catabolic process via UDP-galactose;galactose metabolic process;UDP-glucose catabolic process;UDP-glucose metabolic process","UDP-glucose:hexose-1-phosphate uridylyltransferase activity;zinc ion binding","cytosol;Golgi apparatus","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Metabolic pathways;Prolactin signaling pathway",null,null,2,2,2,"6.3","6.3","6.3","43.363","0.00023602","5.1621",37796000,3,"0.363597",1,"8.08484","0.973678","sp|P07902|GALT_HUMAN;tr|G3V3U5|G3V3U5_HUMAN;tr|G3V223|G3V223_HUMAN;tr|F2Z2X9|F2Z2X9_HUMAN;tr|G3V4G9|G3V4G9_HUMAN","sp|P07902|GALT_HUMAN;tr|G3V3U5|G3V3U5_HUMAN;tr|G3V223|G3V223_HUMAN;tr|F2Z2X9|F2Z2X9_HUMAN;tr|G3V4G9|G3V4G9_HUMAN",907,"P07902","GALT_HUMAN","Galactose-1-phosphate uridylyltransferase","al-1-P uridylyltransferase","GALT"]
["15.8323","16.6315",1,"15.2998",{"$nulls":3},"cell division;central nervous system development;mitotic nuclear envelope reassembly;negative regulation of apoptotic process;negative regulation of phosphorylation;positive regulation of protein dephosphorylation;regulation of catalytic activity","protein phosphatase 2A binding;protein phosphatase regulator activity","endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane",{"$nulls":3},6,6,6,"9.5","9.5","9.5","104.11",0,"13.693",37599000,13,"0.424538",1,"8.08203","1.12861","sp|Q86XL3|ANKL2_HUMAN","sp|Q86XL3|ANKL2_HUMAN",3083,"Q86XL3","ANKL2_HUMAN","Ankyrin repeat and LEM domain-containing protein 2",null,"ANKLE2"]
["16.8375","16.7655",1,"16.4493",{"$nulls":4},"ATP binding;ATPase activity, coupled to transmembrane movement of substances","integral component of membrane",{"$nulls":3},1,1,1,"3.8","3.8","3.8","77.12",0,"10.002",23726000,5,"0.39201",1,"8.07687","1.04559","tr|B4DGL8|B4DGL8_HUMAN;tr|A0A087WW65|A0A087WW65_HUMAN;sp|O75027|ABCB7_HUMAN","tr|B4DGL8|B4DGL8_HUMAN;tr|A0A087WW65|A0A087WW65_HUMAN;sp|O75027|ABCB7_HUMAN",518,"B4DGL8","B4DGL8_HUMAN",null,null,"ABCB7"]
["16.9724","17.7513","17.5704",1,{"$nulls":3},"regulation of transcription, DNA-templated","DNA binding","chromatin;nucleus",{"$nulls":3},2,2,2,"34.3","34.3","34.3","10.767","0.00024919","6.2997",36854000,14,"0.363625",1,"8.07662","0.973747","tr|F5H2U8|F5H2U8_HUMAN;sp|P52926|HMGA2_HUMAN;tr|F5H2A4|F5H2A4_HUMAN;tr|F5H6H0|F5H6H0_HUMAN","tr|F5H2U8|F5H2U8_HUMAN;sp|P52926|HMGA2_HUMAN;tr|F5H2A4|F5H2A4_HUMAN;tr|F5H6H0|F5H6H0_HUMAN",1701,"F5H2U8","F5H2U8_HUMAN",null,null,"HMGA2"]
["19.2466","17.4159","19.5421",1,{"$nulls":3},"signal transduction","protein phosphatase regulator activity","cytoplasm;cytosol;protein phosphatase type 2A complex","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Dopaminergic synapse;Human papillomavirus infection;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway",null,null,3,2,2,"7.3","5.6","5.6","54.699","0.00067234","4.1897",80021000,2,"0.32045",1,"8.0602","0.865187","sp|Q16537|2A5E_HUMAN","sp|Q16537|2A5E_HUMAN",2547,"Q16537","2A5E_HUMAN","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform",null,"PPP2R5E"]
["20.0754","17.0653","20.0301",1,{"$nulls":3},"calcium ion transmembrane transport;hair follicle maturation;protein ubiquitination;ubiquitin-dependent protein catabolic process","calcium channel activity;phosphatase binding","Cul4A-RING E3 ubiquitin ligase complex;plasma membrane",{"$nulls":3},2,2,2,"2.9","2.9","2.9","90.851","0.0083593","2.3511",248470000,5,"0.308884",1,"8.05526","0.836184","sp|Q8TEL6|TP4AP_HUMAN","sp|Q8TEL6|TP4AP_HUMAN",3396,"Q8TEL6","TP4AP_HUMAN","Short transient receptor potential channel 4-associated protein","rp4-associated protein;rpc4-associated protein","TRPC4AP"]
["17.0405","17.0576","17.0065",1,{"$nulls":3},"anterior commissure morphogenesis;cell differentiation involved in salivary gland development;chondrocyte differentiation;Clara cell differentiation;commissural neuron axon guidance;DNA replication;glial cell differentiation;hindbrain development;lung ciliated cell differentiation;negative regulation of DNA binding;negative regulation of epithelial cell proliferation involved in lung morphogenesis;negative regulation of mesenchymal cell proliferation involved in lung development;negative regulation of pri-miRNA transcription from RNA polymerase II promoter;negative regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;principal sensory nucleus of trigeminal nerve development;salivary gland cavitation;Type I pneumocyte differentiation;Type II pneumocyte differentiation","DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription corepressor activity;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cerebellar mossy fiber;fibrillar center;nucleus",{"$nulls":3},5,4,4,"19.3","16.7","16.7","47.441",0,"12.367",72056000,13,"0.376122",1,"8.0458","1.00532","sp|O00712|NFIB_HUMAN;tr|A0A0A0MRX8|A0A0A0MRX8_HUMAN;tr|Q5VW27|Q5VW27_HUMAN;tr|Q5VW30|Q5VW30_HUMAN;tr|Q5VW26|Q5VW26_HUMAN;tr|U3KPY9|U3KPY9_HUMAN;tr|A0A087WXP2|A0A087WXP2_HUMAN;tr|Q5W0Y9|Q5W0Y9_HUMAN;tr|U3KQE8|U3KQE8_HUMAN;tr|Q5VW31|Q5VW31_HUMAN","sp|O00712|NFIB_HUMAN;tr|A0A0A0MRX8|A0A0A0MRX8_HUMAN;tr|Q5VW27|Q5VW27_HUMAN;tr|Q5VW30|Q5VW30_HUMAN;tr|Q5VW26|Q5VW26_HUMAN",250,"O00712","NFIB_HUMAN","Nuclear factor 1 B-type","F1-B;uclear factor 1/B","NFIB"]
["18.0124","17.3613","18.2869",1,{"$nulls":3},"apoptotic process;cellular response to DNA damage stimulus;cellular response to dsRNA;defense response to virus;interferon-gamma-mediated signaling pathway;lipopolysaccharide-mediated signaling pathway;macrophage apoptotic process;MDA-5 signaling pathway;negative regulation of type I interferon production;positive regulation of cytokine secretion;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-beta production;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;positive regulation of type I interferon-mediated signaling pathway;programmed necrotic cell death;regulation of type I interferon production;response to exogenous dsRNA;transcription from RNA polymerase II promoter;TRIF-dependent toll-like receptor signaling pathway;type I interferon biosynthetic process;type I interferon signaling pathway;viral process","DNA binding;identical protein binding;protein domain specific binding;protein homodimerization activity;RNA polymerase II proximal promoter sequence-specific DNA binding;sequence-specific DNA binding;transcription cofactor activity;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytoplasm;cytosol;nucleoplasm;nucleus","Cytosolic DNA-sensing pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;NOD-like receptor signaling pathway;Pertussis;RIG-I-like receptor signaling pathway;Toll-like receptor signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,4,4,4,19,19,19,"47.219","0.00046784","4.9157",20786000,7,"0.346226",1,"8.04342","0.929922","sp|Q14653|IRF3_HUMAN;tr|M0QYT9|M0QYT9_HUMAN;tr|M0R205|M0R205_HUMAN;tr|M0QZB8|M0QZB8_HUMAN;tr|M0QZB7|M0QZB7_HUMAN;tr|M0R3C2|M0R3C2_HUMAN;tr|M0R0R8|M0R0R8_HUMAN;tr|M0R007|M0R007_HUMAN;tr|M0R0X9|M0R0X9_HUMAN;tr|M0QXC8|M0QXC8_HUMAN;tr|M0QX56|M0QX56_HUMAN;tr|M0R3E9|M0R3E9_HUMAN;tr|M0QYX3|M0QYX3_HUMAN","sp|Q14653|IRF3_HUMAN;tr|M0QYT9|M0QYT9_HUMAN;tr|M0R205|M0R205_HUMAN;tr|M0QZB8|M0QZB8_HUMAN;tr|M0QZB7|M0QZB7_HUMAN;tr|M0R3C2|M0R3C2_HUMAN",2374,"Q14653","IRF3_HUMAN","Interferon regulatory factor 3","RF-3","IRF3"]
["16.8445","16.6413","16.4004",1,{"$nulls":3},"cilium assembly",null,"cilium",{"$nulls":3},1,1,1,"4.6","4.6","4.6","30.811","0.0037129","3.0494",8849700,3,"0.391537",1,"8.0427","1.04439","sp|Q96LJ8|UBX10_HUMAN","sp|Q96LJ8|UBX10_HUMAN",3767,"Q96LJ8","UBX10_HUMAN","UBX domain-containing protein 10 {ECO:0000305}",null,"UBXN10"]
["17.4518","17.8348","18.2325",1,{"$nulls":5},"cytoplasmic vesicle;integral component of membrane;peroxisomal membrane",{"$nulls":3},3,3,3,"19.2","19.2","19.2","18.44",0,"24.111",216790000,24,"0.346807",1,"8.02702","0.931383","sp|Q53FP2|TMM35_HUMAN","sp|Q53FP2|TMM35_HUMAN",2647,"Q53FP2","TM35A_HUMAN","Transmembrane protein 35A",null,"TMEM35A"]
["17.0443","15.6997",1,"15.7649",{"$nulls":5},"cytosol;mitochondrion",{"$nulls":3},4,4,4,23,23,23,"25.961",0,"25.234",222910000,21,"0.404663",1,"7.98957","1.07778","sp|Q96LL9|DJC30_HUMAN","sp|Q96LL9|DJC30_HUMAN",3768,"Q96LL9","DJC30_HUMAN","DnaJ homolog subfamily C member 30",null,"DNAJC30"]
["16.6974","17.052","16.7778",1,{"$nulls":4},"RNA binding",{"$nulls":4},2,2,2,"5.3","5.3","5.3","50.313","0.00025019","6.3696",3025600000,16,"0.378774",1,"7.98579","1.01203","tr|S4R446|S4R446_HUMAN;sp|Q86XN8|MEX3D_HUMAN","tr|S4R446|S4R446_HUMAN;sp|Q86XN8|MEX3D_HUMAN",3084,"S4R446","S4R446_HUMAN",null,null,"MEX3D"]
["17.2297","17.616",1,"17.8871",{"$nulls":3},"nucleocytoplasmic transport",null,"nuclear pore",{"$nulls":3},2,2,2,"3.5","3.5","3.5","49.095","0.0008797","3.9394",21709000,3,"0.352123",1,"7.97924","0.944761","tr|Q5JRG1|Q5JRG1_HUMAN;tr|H7BYF2|H7BYF2_HUMAN;sp|Q9BVL2|NUPL1_HUMAN","tr|Q5JRG1|Q5JRG1_HUMAN;tr|H7BYF2|H7BYF2_HUMAN;sp|Q9BVL2|NUPL1_HUMAN",4013,"Q5JRG1","Q5JRG1_HUMAN",null,null,"NUP58"]
["15.6213","17.3883","16.0645",1,{"$nulls":3},"calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;cellular protein localization;cytoskeleton organization;focal adhesion assembly;G2/M transition of mitotic cell cycle;gene silencing by miRNA;glycerophospholipid biosynthetic process;lamellipodium assembly;negative regulation of hippo signaling;negative regulation of kinase activity;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;positive regulation of gene silencing by miRNA;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of MAP kinase activity;positive regulation of protein complex assembly;regulation of cell migration;regulation of cellular response to hypoxia;regulation of GTPase activity;regulation of transcription, DNA-templated;response to hypoxia;transcription, DNA-templated;wound healing, spreading of epidermal cells","actin filament binding;alpha-catenin binding;chromatin binding;metal ion binding;transcription corepressor activity","adherens junction;cell-cell junction;cytosol;focal adhesion;Golgi apparatus;lamellipodium;microtubule organizing center;nucleus;P-body;plasma membrane;transcription factor complex","Hippo signaling pathway;Hippo signaling pathway - multiple species",null,null,1,1,1,"4.5","4.5","4.5","56.933","0.0023187","3.3545",14189000,3,"0.394239",1,"7.97254","1.05125","sp|Q96IF1|AJUBA_HUMAN","sp|Q96IF1|AJUBA_HUMAN",3732,"Q96IF1","AJUBA_HUMAN","LIM domain-containing protein ajuba",null,"AJUBA"]
["16.9227","17.5472","17.5488",1,{"$nulls":3},"ER to Golgi vesicle-mediated transport;protein folding;protein transport","mannose binding;metal ion binding","COPII-coated ER to Golgi transport vesicle;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;integral component of membrane",{"$nulls":3},2,2,2,"7.8","7.8","7.8","39.71","0.0054141","2.6717",27672000,2,"0.358722",1,"7.96054","0.961384","sp|Q9H0V9|LMA2L_HUMAN","sp|Q9H0V9|LMA2L_HUMAN",4149,"Q9H0V9","LMA2L_HUMAN","VIP36-like protein",null,"LMAN2L"]
["17.0296","17.2678","17.3841",1,{"$nulls":3},"positive regulation of transcription, DNA-templated","DNA binding","nucleus",{"$nulls":3},2,2,2,"6.1","6.1","6.1","57.958","0.0086973","2.2903",13527000,2,"0.362599",1,"7.95665","0.971159","tr|U3KQS6|U3KQS6_HUMAN;tr|A0A0A0MQU7|A0A0A0MQU7_HUMAN;sp|P20823|HNF1A_HUMAN;tr|F5H0K0|F5H0K0_HUMAN;tr|A0A0A0MTK8|A0A0A0MTK8_HUMAN;tr|A0A087WYP0|A0A087WYP0_HUMAN;tr|H0YND5|H0YND5_HUMAN;tr|E0YMI9|E0YMI9_HUMAN","tr|U3KQS6|U3KQS6_HUMAN;tr|A0A0A0MQU7|A0A0A0MQU7_HUMAN;sp|P20823|HNF1A_HUMAN;tr|F5H0K0|F5H0K0_HUMAN;tr|A0A0A0MTK8|A0A0A0MTK8_HUMAN;tr|A0A087WYP0|A0A087WYP0_HUMAN;tr|H0YND5|H0YND5_HUMAN;tr|E0YMI9|E0YMI9_HUMAN",1155,"U3KQS6","U3KQS6_HUMAN",null,null,"HNF1A"]
["18.2707","17.0778","18.4486",1,{"$nulls":9},3,3,3,"35.7","35.7","35.7","15.556","0.00068058","4.3673",64012000,5,"0.337951",1,"7.94993","0.909121","tr|B5MC22|B5MC22_HUMAN;sp|Q9UDX5|MTFP1_HUMAN;tr|F8WEN7|F8WEN7_HUMAN;tr|H7C417|H7C417_HUMAN","tr|B5MC22|B5MC22_HUMAN;sp|Q9UDX5|MTFP1_HUMAN;tr|F8WEN7|F8WEN7_HUMAN;tr|H7C417|H7C417_HUMAN",4690,"B5MC22","B5MC22_HUMAN",null,null,"MTFP1"]
["16.3269","14.8361","14.2639",1,{"$nulls":3},"bile acid biosynthetic process;cellular response to cholesterol;positive regulation of proteasomal protein catabolic process;regulation of autophagy","cholesterol binding;sterol transporter activity","autophagosome;cytosol;endoplasmic reticulum membrane;perinuclear endoplasmic reticulum;plasma membrane",{"$nulls":3},10,10,10,"18.5","18.5","18.5","95.43",0,"25.997",237650000,38,"0.448818",1,"7.94957","1.19118","sp|Q9BZF2|OSBL7_HUMAN;tr|J3QLK7|J3QLK7_HUMAN","sp|Q9BZF2|OSBL7_HUMAN;tr|J3QLK7|J3QLK7_HUMAN",4077,"Q9BZF2","OSBL7_HUMAN","Oxysterol-binding protein-related protein 7","RP-7;SBP-related protein 7","OSBPL7"]
["17.4802","17.7033","18.2983",1,{"$nulls":5},"cytosol;nucleoplasm",{"$nulls":3},3,3,3,"16.3","16.3","16.3","30.785",0,"8.0953",18250000,5,"0.341577",1,"7.94259","0.918232","tr|K7EIY6|K7EIY6_HUMAN;sp|Q9BV68|RN126_HUMAN;tr|U3KQF4|U3KQF4_HUMAN;tr|U3KPY8|U3KPY8_HUMAN","tr|K7EIY6|K7EIY6_HUMAN;sp|Q9BV68|RN126_HUMAN",4001,"K7EIY6","K7EIY6_HUMAN",null,null,"RNF126"]
["17.2276","17.1261","17.4827",1,{"$nulls":3},"cerebellar Purkinje cell layer morphogenesis;ubiquinone biosynthetic process","ATP binding;kinase activity","cytosol;integral component of membrane;mitochondrial membrane;mitochondrion;plasma membrane",{"$nulls":3},3,3,3,"10.8","10.8","10.8","60.069","0.00067446","4.22",34308000,7,"0.359308",1,"7.93546","0.962862","sp|Q96D53|ADCK4_HUMAN;tr|M0R001|M0R001_HUMAN;tr|M0R362|M0R362_HUMAN;tr|M0QZZ2|M0QZZ2_HUMAN;tr|M0R3F7|M0R3F7_HUMAN;tr|M0R011|M0R011_HUMAN","sp|Q96D53|ADCK4_HUMAN;tr|M0R001|M0R001_HUMAN",3646,"Q96D53","COQ8B_HUMAN","Atypical kinase COQ8B, mitochondrial {ECO:0000305}",null,"COQ8B"]
["17.9452","17.2647","18.4048",1,{"$nulls":3},"Fc-gamma receptor signaling pathway involved in phagocytosis","actin binding","cytoskeleton;cytosol","Endocytosis;Yersinia infection",null,null,4,4,4,13,13,13,"46.288",0,"8.0494",74177000,10,"0.337265",1,"7.90257","0.907396","sp|Q8TF74|WIPF2_HUMAN;tr|J3QKM5|J3QKM5_HUMAN;tr|A8MWR2|A8MWR2_HUMAN","sp|Q8TF74|WIPF2_HUMAN",3408,"Q8TF74","WIPF2_HUMAN","WAS/WASL-interacting protein family member 2",null,"WIPF2"]
["19.3874","17.3781","19.9924",1,{"$nulls":3},"dephosphorylation of RNA polymerase II C-terminal domain;mRNA polyadenylation;termination of RNA polymerase II transcription","CTD phosphatase activity","cytosol;mRNA cleavage and polyadenylation specificity factor complex;nucleoplasm","mRNA surveillance pathway",null,null,3,3,3,"20.1","20.1","20.1","22.574","0.0067141","2.5353",39776000,3,"0.304773",1,"7.88651","0.82588","sp|Q9NP77|SSU72_HUMAN","sp|Q9NP77|SSU72_HUMAN",4356,"Q9NP77","SSU72_HUMAN","RNA polymerase II subunit A C-terminal domain phosphatase SSU72","TD phosphatase SSU72","SSU72"]
["16.4972","17.051","16.7785",1,{"$nulls":3},"maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","ribonucleoprotein complex binding","chromosome;cytosol;nucleolus;nucleoplasm;nucleus;preribosome, large subunit precursor",{"$nulls":3},22,22,22,"41.3","41.3","41.3","66.077",0,"74.773",1582600000,157,"0.373555",1,"7.88485","0.998825","tr|B5MCF9|B5MCF9_HUMAN;sp|O00541|PESC_HUMAN;tr|B3KXD6|B3KXD6_HUMAN;tr|H7C267|H7C267_HUMAN;tr|H7BYY8|H7BYY8_HUMAN","tr|B5MCF9|B5MCF9_HUMAN;sp|O00541|PESC_HUMAN;tr|B3KXD6|B3KXD6_HUMAN",240,"B5MCF9","B5MCF9_HUMAN","Pescadillo homolog {ECO:0000256|HAMAP-Rule:MF_03028}"]
["17.3607","17.2859","17.8772",1,{"$nulls":3},"activation of MAPK activity;activation of MAPKKK activity;aorta development;cardiac septum development;coronary vasculature development;Fc-epsilon receptor signaling pathway;heart morphogenesis;I-kappaB kinase/NF-kappaB signaling;in utero embryonic development;JNK cascade;lung development;MyD88-dependent toll-like receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of NF-kappaB transcription factor activity;protein deubiquitination;stimulatory C-type lectin receptor signaling pathway;transforming growth factor beta receptor signaling pathway","enzyme activator activity;kinase activator activity;mitogen-activated protein kinase p38 binding;protein complex binding;protein serine/threonine phosphatase activity","cytosol;endosome membrane;nuclear speck;protein complex","Epstein-Barr virus infection;Hepatitis B;Herpes simplex virus 1 infection;Human immunodeficiency virus 1 infection;Leishmaniasis;MAPK signaling pathway;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Osteoclast differentiation;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Yersinia infection",null,null,4,4,4,"12.3","12.3","12.3","54.643","0.00233","3.3941",27316000,4,"0.347985",1,"7.88467","0.934347","sp|Q15750|TAB1_HUMAN","sp|Q15750|TAB1_HUMAN",2518,"Q15750","TAB1_HUMAN","TGF-beta-activated kinase 1 and MAP3K7-binding protein 1",null,"TAB1"]
["17.3184","16.7582","17.3257",1,{"$nulls":9},8,8,8,"41.7","41.7","41.7","27.586",0,"26.238",157440000,19,"0.359849",1,"7.87547","0.964226","tr|X6R3X1|X6R3X1_HUMAN;sp|Q6NUK4|REEP3_HUMAN","tr|X6R3X1|X6R3X1_HUMAN;sp|Q6NUK4|REEP3_HUMAN",2833,"X6R3X1"]
["17.2303","16.5738","17.1624",1,{"$nulls":3},"cellular response to interferon-gamma;cellular response to virus;chemotaxis;ERK1 and ERK2 cascade;female pregnancy;inflammatory response;maternal process involved in female pregnancy;natural killer cell tolerance induction;negative regulation of activated T cell proliferation;negative regulation of CD4-positive, alpha-beta T cell proliferation;negative regulation of chemokine production;negative regulation of gene expression;negative regulation of interferon-gamma production;negative regulation of mast cell degranulation;negative regulation of natural killer cell mediated cytotoxicity;negative regulation of tumor necrosis factor production;p38MAPK cascade;positive regulation of activated T cell autonomous cell death;positive regulation of CD4-positive, alpha-beta T cell proliferation;positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;positive regulation of dendritic cell apoptotic process;positive regulation of dendritic cell chemotaxis;positive regulation of dendritic cell differentiation;positive regulation of ERK1 and ERK2 cascade;positive regulation of gene expression;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-gamma secretion;positive regulation of interleukin-1 beta secretion;positive regulation of interleukin-10 secretion;positive regulation of interleukin-12 secretion;positive regulation of interleukin-13 secretion;positive regulation of interleukin-4 production;positive regulation of interleukin-6 secretion;positive regulation of interleukin-8 secretion;positive regulation of monocyte chemotactic protein-1 production;positive regulation of NF-kappaB import into nucleus;positive regulation of NF-kappaB transcription factor activity;positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;positive regulation of transforming growth factor beta production;positive regulation of tumor necrosis factor secretion;positive regulation of viral entry into host cell;response to interleukin-1;response to lipopolysaccharide","carbohydrate binding;disaccharide binding;enzyme binding;galactose binding;signal transducer activity","cytoplasm;cytosol;extracellular exosome;extracellular space;intracellular;nucleus",{"$nulls":3},2,2,2,"7.6","7.6","7.6","39.518","0.0012993","3.7039",15982000,2,"0.360943",1,"7.82084","0.966983","sp|O00182|LEG9_HUMAN;tr|J3QS92|J3QS92_HUMAN;tr|J3KSA0|J3KSA0_HUMAN","sp|O00182|LEG9_HUMAN;tr|J3QS92|J3QS92_HUMAN;tr|J3KSA0|J3KSA0_HUMAN",196,"O00182","LEG9_HUMAN","Galectin-9","al-9","LGALS9"]
["19.4271","16.5547","19.3473",1,{"$nulls":3},"autophagosome maturation;autophagosome membrane docking;endoplasmic reticulum-Golgi intermediate compartment organization;ER to Golgi vesicle-mediated transport;exocytosis;Golgi organization;intracellular protein transport;protein localization to phagophore assembly site;vesicle docking;vesicle fusion","protein kinase binding;protein phosphatase binding;SNAP receptor activity;SNARE binding","autophagosome;autophagosome membrane;COPII-coated ER to Golgi transport vesicle;cytosol;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;ER to Golgi transport vesicle membrane;ER-mitochondrion membrane contact site;integral component of membrane;mitochondrion;plasma membrane;smooth endoplasmic reticulum membrane;SNARE complex","Autophagy - animal;SNARE interactions in vesicular transport",null,null,2,2,2,"9.6","9.6","9.6","33.403",0,"9.1797",82728000,10,"0.31116",1,"7.81728","0.841891","sp|P56962|STX17_HUMAN;tr|E9PJW1|E9PJW1_HUMAN;tr|E9PQU9|E9PQU9_HUMAN;tr|E9PJV6|E9PJV6_HUMAN;tr|E9PIC2|E9PIC2_HUMAN","sp|P56962|STX17_HUMAN;tr|E9PJW1|E9PJW1_HUMAN;tr|E9PQU9|E9PQU9_HUMAN;tr|E9PJV6|E9PJV6_HUMAN;tr|E9PIC2|E9PIC2_HUMAN",1789,"P56962","STX17_HUMAN","Syntaxin-17 {ECO:0000303|PubMed:21545355}",null,"STX17"]
["16.4935","17.0514","16.917",1,{"$nulls":3},"deoxynucleotide transport;mitochondrial transport;thiamine pyrophosphate transmembrane transport;thiamine-containing compound metabolic process","deoxynucleotide transmembrane transporter activity;thiamine pyrophosphate transmembrane transporter activity;thiamine transmembrane transporter activity","integral component of mitochondrial inner membrane;mitochondrial inner membrane;nucleus",{"$nulls":3},3,3,3,"10.3","10.3","10.3","35.511",0,"8.7982",134640000,14,"0.366596",1,"7.81401","0.981245","sp|Q9HC21|TPC_HUMAN;tr|J3KTL0|J3KTL0_HUMAN;tr|J3KSI7|J3KSI7_HUMAN;tr|J3QL84|J3QL84_HUMAN;tr|J3KS44|J3KS44_HUMAN;tr|J3QLV3|J3QLV3_HUMAN;tr|J3KRY6|J3KRY6_HUMAN","sp|Q9HC21|TPC_HUMAN",4316,"Q9HC21","TPC_HUMAN","Mitochondrial thiamine pyrophosphate carrier",null,"SLC25A19"]
["18.9359","17.1285","19.4461",1,{"$nulls":3},"G-protein coupled receptor signaling pathway;nucleobase-containing small molecule catabolic process;platelet activation;purine ribonucleoside diphosphate catabolic process","ATP binding;nucleoside-diphosphatase activity;nucleoside-triphosphatase activity","basal lamina;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;plasma membrane","Metabolic pathways;Purine metabolism;Taste transduction",null,null,2,2,2,"5.1","5.1","5.1","53.665","0.0017138","3.531",76921000,9,"0.311466",1,"7.80912","0.842659","sp|Q9Y5L3|ENTP2_HUMAN","sp|Q9Y5L3|ENTP2_HUMAN",5045,"Q9Y5L3","ENTP2_HUMAN","Ectonucleoside triphosphate diphosphohydrolase 2","TPDase 2","ENTPD2"]
["15.5495","15.4555",1,"14.3943",{"$nulls":3},"activation of GTPase activity;intracellular protein transport;regulation of vesicle fusion","14-3-3 protein binding;GTPase activator activity;Rab GTPase binding","endomembrane system;intracellular",{"$nulls":3},2,2,2,"5.5","5.5","5.5","59.08","0.0015005","3.5424",16474000,5,"0.438861",1,"7.80537","1.16545","sp|Q9NU19|TB22B_HUMAN","sp|Q9NU19|TB22B_HUMAN",4457,"Q9NU19","TB22B_HUMAN","TBC1 domain family member 22B",null,"TBC1D22B"]
["15.1076","17.7093",1,"16.2157",{"$nulls":3},"ATF6-mediated unfolded protein response;endoplasmic reticulum unfolded protein response;eye development;positive regulation of apoptotic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response;protein folding;regulation of transcription from RNA polymerase II promoter;response to stress;signal transduction;visual perception","cAMP response element binding;DNA binding transcription factor activity;identical protein binding;protein heterodimerization activity;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;sequence-specific DNA binding;transcription coactivator activity;transcription regulatory region sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;ubiquitin protein ligase binding","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;integral component of endoplasmic reticulum membrane;membrane;nuclear envelope;nucleoplasm;nucleus","Alzheimer disease;Protein processing in endoplasmic reticulum",null,null,3,3,3,"6.3","6.3","6.3","74.584","0.00066504","4.0513",55801000,6,"0.378237",1,"7.80062","1.01067","sp|P18850|ATF6A_HUMAN","sp|P18850|ATF6A_HUMAN",1124,"P18850","ATF6A_HUMAN","Cyclic AMP-dependent transcription factor ATF-6 alpha","AMP-dependent transcription factor ATF-6 alpha","ATF6"]
["18.0232","16.7715","18.2009",1,{"$nulls":4},"aminopeptidase activity;identical protein binding;serine-type peptidase activity","cytosol;nucleus",{"$nulls":3},6,6,6,"8.9","8.9","8.9","98.262",0,"28.024",85189000,6,"0.335984",1,"7.7969","0.904179","sp|Q86TI2|DPP9_HUMAN;tr|M0R2A8|M0R2A8_HUMAN;tr|M0R3C4|M0R3C4_HUMAN;tr|M0R2G6|M0R2G6_HUMAN;tr|M0R0I1|M0R0I1_HUMAN;tr|M0R1L4|M0R1L4_HUMAN","sp|Q86TI2|DPP9_HUMAN;tr|M0R2A8|M0R2A8_HUMAN",3034,"Q86TI2","DPP9_HUMAN","Dipeptidyl peptidase 9","P9","DPP9"]
["14.4047","14.8178",1,"12.6353",{"$nulls":3},"microtubule cytoskeleton organization;mitotic cytokinesis;mRNA processing;negative regulation of apoptotic process;regulation of cell cycle;regulation of mRNA splicing, via spliceosome;regulation of RNA splicing;RNA splicing","DNA binding;RNA binding;RS domain binding","nuclear speck",{"$nulls":3},18,18,18,"12.3","12.3","12.3","263.83",0,"55.453",306940000,53,"0.505126",1,"7.79364","1.33881","sp|P18583|SON_HUMAN;tr|H7C1M2|H7C1M2_HUMAN;tr|J3QSZ5|J3QSZ5_HUMAN;tr|H7C2G8|H7C2G8_HUMAN","sp|P18583|SON_HUMAN",1118,"P18583","SON_HUMAN","Protein SON",null,"SON"]
["17.2744","16.7524","17.4673",1,{"$nulls":3},"neutrophil degranulation","RNA binding","extracellular region;ficolin-1-rich granule lumen;secretory granule lumen",{"$nulls":3},6,6,6,24,24,24,"29.411",0,"26.675",202150000,43,"0.351978",1,"7.77974","0.944397","sp|Q9BU76|MMTA2_HUMAN","sp|Q9BU76|MMTA2_HUMAN",3980,"Q9BU76","MMTA2_HUMAN","Multiple myeloma tumor-associated protein 2","MMTAG2","MMTAG2"]
["16.699","16.8536","17.0014",1,{"$nulls":3},"carbohydrate phosphorylation;D-ribose catabolic process;pentose-phosphate shunt","ATP binding;carbohydrate kinase activity;metal ion binding;ribokinase activity","cytoplasm;cytosol;extracellular exosome;nucleus","Metabolic pathways;Pentose phosphate pathway",null,null,1,1,1,4,4,4,"34.143","0.0044935","2.9081",9984200,4,"0.362859",1,"7.77557","0.971816","sp|Q9H477|RBSK_HUMAN","sp|Q9H477|RBSK_HUMAN",4201,"Q9H477","RBSK_HUMAN","Ribokinase {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000303|PubMed:17585908}","K {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000303|PubMed:17585908}","RBKS"]
["18.0246","16.9018","18.3827",1,{"$nulls":3},"adult walking behavior;cellular response to hydroperoxide;negative regulation of neuron apoptotic process;negative regulation of oxidative stress-induced neuron death;negative regulation of peptidyl-cysteine S-nitrosylation;neuron apoptotic process;response to oxidative stress","oxidoreductase activity","mitochondrion;nucleolus",{"$nulls":3},5,5,5,"10.6","10.6","10.6","97.969",0,"8.8633",74111000,11,"0.331274",1,"7.77188","0.892349","sp|Q8N573|OXR1_HUMAN;tr|H0YC07|H0YC07_HUMAN","sp|Q8N573|OXR1_HUMAN",3234,"Q8N573","OXR1_HUMAN","Oxidation resistance protein 1",null,"OXR1"]
["14.5019","16.3946","14.3761",1,{"$nulls":3},"cell proliferation;clathrin coat assembly;endocytic recycling;epidermal growth factor receptor signaling pathway;Golgi to endosome transport;membrane organization;negative regulation of epidermal growth factor receptor signaling pathway;positive regulation of receptor recycling;protein transport;receptor-mediated endocytosis of virus by host cell;regulation of cell proliferation;vesicle organization;viral entry into host cell","cadherin binding;calcium ion binding;identical protein binding;polyubiquitin modification-dependent protein binding;SH3 domain binding","aggresome;AP-2 adaptor complex;apical plasma membrane;basal plasma membrane;ciliary membrane;clathrin-coated pit;cytosol;early endosome membrane;intracellular membrane-bounded organelle;membrane;plasma membrane","Endocytosis",null,null,3,3,3,"5.6","5.6","5.6","98.655","0.00025961","7.1885",15883000,5,"0.432425",1,"7.76021","1.14887","sp|P42566|EPS15_HUMAN;tr|B1AUU8|B1AUU8_HUMAN","sp|P42566|EPS15_HUMAN;tr|B1AUU8|B1AUU8_HUMAN",1472,"P42566","EPS15_HUMAN","Epidermal growth factor receptor substrate 15","rotein Eps15","EPS15"]
["16.9223","18.2992",1,"18.7184",{"$nulls":4},"lamin binding;NADH dehydrogenase activity","lamin filament;nuclear lamina;nuclear lumen;nucleolus;nucleus",{"$nulls":3},4,4,2,"11.2","11.2","6.8","51.156",0,"8.3191",32639000,5,"0.323303",1,"7.75157","0.872346","sp|Q9UHQ1|NARF_HUMAN;tr|E7EP87|E7EP87_HUMAN;tr|A0A088AWN8|A0A088AWN8_HUMAN;tr|J3KS48|J3KS48_HUMAN;tr|J3KT43|J3KT43_HUMAN;tr|E9PH27|E9PH27_HUMAN;tr|J3KTP5|J3KTP5_HUMAN;tr|J3QRB0|J3QRB0_HUMAN;tr|J3KRH7|J3KRH7_HUMAN;tr|J3QL28|J3QL28_HUMAN;tr|J3QSD9|J3QSD9_HUMAN","sp|Q9UHQ1|NARF_HUMAN;tr|E7EP87|E7EP87_HUMAN;tr|A0A088AWN8|A0A088AWN8_HUMAN;tr|J3KS48|J3KS48_HUMAN;tr|J3KT43|J3KT43_HUMAN;tr|E9PH27|E9PH27_HUMAN;tr|J3KTP5|J3KTP5_HUMAN;tr|J3QRB0|J3QRB0_HUMAN;tr|J3KRH7|J3KRH7_HUMAN",4732,"Q9UHQ1","NARF_HUMAN","Nuclear prelamin A recognition factor",null,"NARF"]
["16.1015","15.7645",1,"15.3637",{"$nulls":4},"actin binding;cadherin binding","actin cytoskeleton;cytosol;focal adhesion",{"$nulls":3},14,14,7,"19.1","19.1","9.8","116.53",0,"38.928",178230000,29,"0.405133",1,"7.75118","1.07898","sp|Q6WCQ1|MPRIP_HUMAN;tr|J3KSW8|J3KSW8_HUMAN;tr|H0Y7E2|H0Y7E2_HUMAN;tr|H7C3G6|H7C3G6_HUMAN;tr|J3KSK7|J3KSK7_HUMAN;tr|K7EL39|K7EL39_HUMAN;tr|J3QRL2|J3QRL2_HUMAN;tr|A8MZF8|A8MZF8_HUMAN","sp|Q6WCQ1|MPRIP_HUMAN;tr|J3KSW8|J3KSW8_HUMAN",2919,"Q6WCQ1","MPRIP_HUMAN","Myosin phosphatase Rho-interacting protein",{"$f":"-RIP","v":{"$error":"#NAME?"}},"MPRIP"]
["19.2974","17.0517","19.8474",1,{"$nulls":3},"hyaluronan catabolic process;regulation of G2/M transition of mitotic cell cycle","hyaluronic acid binding","cell surface;cytosol;membrane;plasma membrane","ECM-receptor interaction",null,null,16,16,15,25,25,24,"84.099",0,"54.784",509790000,51,"0.301115",1,"7.75085","0.816709","sp|O75330|HMMR_HUMAN;tr|E5RIH2|E5RIH2_HUMAN;tr|E5RI30|E5RI30_HUMAN","sp|O75330|HMMR_HUMAN",545,"O75330","HMMR_HUMAN","Hyaluronan mediated motility receptor",null,"HMMR"]
["16.3229","17.1281","16.9601",1,{"$nulls":4},"nucleic acid binding",{"$nulls":4},1,1,1,9,9,9,"18.755","0.004878","2.8486",6892900,2,"0.361888",1,"7.74544","0.969366","tr|H0YKA3|H0YKA3_HUMAN;sp|Q9Y6X8|ZHX2_HUMAN","tr|H0YKA3|H0YKA3_HUMAN;sp|Q9Y6X8|ZHX2_HUMAN",5119,"H0YKA3","H0YKA3_HUMAN",null,null,"ZHX2"]
["17.0505","15.769","16.3371",1,{"$nulls":3},"agmatine biosynthetic process;negative regulation of protein catabolic process;positive regulation of catalytic activity;positive regulation of polyamine transmembrane transport;putrescine biosynthetic process from ornithine;putrescine transport;spermatogenesis;trans-Golgi network membrane organization","arginine decarboxylase activity;ornithine decarboxylase activator activity;putrescine transmembrane transporter activity","axon;cis-Golgi network;cytoplasmic vesicle;cytosol;dendrite;endoplasmic reticulum-Golgi intermediate compartment membrane;granular vesicle;mitochondrion;nucleus;perikaryon;perinuclear region of cytoplasm;trans-Golgi network;transport vesicle","Arginine and proline metabolism;Metabolic pathways",null,null,1,1,1,"1.5","1.5","1.5","49.979","0.0068843","2.505",221020000,13,"0.376378",1,"7.74118","1.00596","sp|Q96A70|AZIN2_HUMAN","sp|Q96A70|AZIN2_HUMAN",3597,"Q96A70","AZIN2_HUMAN","Antizyme inhibitor 2","zI2","AZIN2"]
["17.5572","16.9671",1,"18.0423",{"$nulls":3},"NAD metabolic process;NADP biosynthetic process","NAD+ kinase activity",{"$nulls":4},2,2,2,"7.5","7.5","7.5","45.233",0,"9.3732",13367000,3,"0.337465",1,"7.741","0.907899","tr|A0A0A0MR98|A0A0A0MR98_HUMAN;sp|O95544|NADK_HUMAN;tr|J3KTI3|J3KTI3_HUMAN","tr|A0A0A0MR98|A0A0A0MR98_HUMAN;sp|O95544|NADK_HUMAN;tr|J3KTI3|J3KTI3_HUMAN",741,"A0A0A0MR98","A0A0A0MR98_HUMAN",null,null,"NADK"]
["17.5406","17.027","18.1004",1,{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;interferon-gamma-mediated signaling pathway;regulation of immune response;type I interferon signaling pathway;viral process","peptide antigen binding","cell surface;early endosome membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},6,1,0,"26.8","3.8",0,"40.968","0.0015155","3.7017",21535000,2,"0.335948",1,"7.73362","0.904088","sp|Q29963|1C06_HUMAN;sp|P30480|1B42_HUMAN;sp|P30460|1B08_HUMAN;sp|P01889|1B07_HUMAN;sp|Q95365|1B38_HUMAN;sp|Q29836|1B67_HUMAN;sp|Q29718|1B82_HUMAN;sp|P30475|1B39_HUMAN;tr|Q6DU44|Q6DU44_HUMAN;sp|P13747|HLAE_HUMAN","sp|Q29963|1C06_HUMAN;sp|P30480|1B42_HUMAN;sp|P30460|1B08_HUMAN;sp|P01889|1B07_HUMAN;sp|Q95365|1B38_HUMAN;sp|Q29836|1B67_HUMAN;sp|Q29718|1B82_HUMAN;sp|P30475|1B39_HUMAN",2589,"Q29963","1C06_HUMAN","HLA class I histocompatibility antigen, Cw-6 alpha chain",null,"HLA-C"]
["16.4746","16.5997","16.6122",1,{"$nulls":3},"actomyosin structure organization;positive regulation of cell adhesion;positive regulation of gene expression;positive regulation of keratinocyte migration;wound healing","cytoskeletal protein binding;structural constituent of cytoskeleton","apical part of cell;bicellular tight junction;cytoplasm;cytoskeleton;cytosol;plasma membrane","Tight junction",null,null,7,5,5,"7.7","5.8","5.8","99.711",0,"19.463",196600000,15,"0.3702",1,"7.73101","0.990347","sp|Q9H329|E41LB_HUMAN","sp|Q9H329|E41LB_HUMAN",4182,"Q9H329","E41LB_HUMAN","Band 4.1-like protein 4B",null,"EPB41L4B"]
["17.4326","16.6267","17.6104",1,{"$nulls":3},"protein ubiquitination",null,"cytosol;extracellular exosome;Golgi apparatus;plasma membrane",{"$nulls":3},2,2,2,"9.4","9.4","9.4","45.338","0.003719","3.084",31148000,4,"0.34585",1,"7.72442","0.928976","sp|Q9BSL1|UBAC1_HUMAN","sp|Q9BSL1|UBAC1_HUMAN",3952,"Q9BSL1","UBAC1_HUMAN","Ubiquitin-associated domain-containing protein 1","BA domain-containing protein 1","UBAC1"]
["15.5985","16.1313","15.2927",1,{"$nulls":3},"anion homeostasis;arginine biosynthetic process;carbamoyl phosphate biosynthetic process;cellular response to ammonia;cellular response to cAMP;cellular response to fibroblast growth factor stimulus;cellular response to glucagon stimulus;cellular response to oleic acid;citrulline biosynthetic process;'de novo' pyrimidine nucleobase biosynthetic process;glutamine metabolic process;hepatocyte differentiation;homocysteine metabolic process;midgut development;nitric oxide metabolic process;response to amine;response to amino acid;response to dexamethasone;response to drug;response to food;response to growth hormone;response to lipopolysaccharide;response to starvation;response to toxic substance;response to zinc ion;triglyceride catabolic process;urea cycle;vasodilation","ATP binding;calcium ion binding;carbamoyl-phosphate synthase (ammonia) activity;carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;endopeptidase activity;glutamate binding;modified amino acid binding;phospholipid binding;protein complex binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrial nucleoid;nucleolus;protein complex","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Nitrogen metabolism",null,null,3,2,2,"2.2","1.7","1.7","164.94","0.00067522","4.2379",32408000,4,"0.405267",1,"7.71855","1.07932","sp|P31327|CPSM_HUMAN;tr|Q5R211|Q5R211_HUMAN","sp|P31327|CPSM_HUMAN",1329,"P31327","CPSM_HUMAN","Carbamoyl-phosphate synthase [ammonia], mitochondrial",null,"CPS1"]
["17.7462","16.5473",1,"17.8667",{"$nulls":3},"3'-phosphoadenosine 5'-phosphosulfate metabolic process;chondrocyte development;chondroitin sulfate metabolic process;embryonic digit morphogenesis;endochondral ossification;inositol biosynthetic process;phosphatidylinositol phosphorylation;post-embryonic development","3'(2'),5'-bisphosphate nucleotidase activity;3'-nucleotidase activity;inositol monophosphate 1-phosphatase activity;inositol monophosphate 3-phosphatase activity;inositol monophosphate 4-phosphatase activity;metal ion binding","cytosol;Golgi apparatus;Golgi lumen;integral component of membrane;membrane;nuclear body;nucleus","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Sulfur metabolism",null,null,2,2,2,"4.7","4.7","4.7","38.681","0.0048632","2.8184",23713000,5,"0.339228",1,"7.7134","0.912328","sp|Q9NX62|IMPA3_HUMAN","sp|Q9NX62|IMPA3_HUMAN",4536,"Q9NX62","IMPA3_HUMAN","Inositol monophosphatase 3","MP 3;MPase 3","IMPAD1"]
["18.9245","16.4907","18.9944",1,{"$nulls":3},"apoptotic process;blood vessel development;cell cycle;circadian regulation of gene expression;negative regulation of transcription, DNA-templated;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of B cell proliferation;regulation of gene expression;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;response to toxic substance;response to xenobiotic stimulus;transcription from RNA polymerase II promoter;xenobiotic metabolic process","aryl hydrocarbon receptor activity;DNA binding;DNA binding transcription factor activity;E-box binding;enhancer binding;Hsp90 protein binding;nuclear receptor activity;protein dimerization activity;protein heterodimerization activity;TBP-class protein binding;TFIID-class transcription factor binding;transcription coactivator binding;transcription factor binding;transcription regulatory region DNA binding","cytoplasm;cytosol;cytosolic aryl hydrocarbon receptor complex;nuclear aryl hydrocarbon receptor complex;nucleoplasm;nucleus;protein complex;transcription factor complex","Cushing syndrome;Th17 cell differentiation",null,null,13,13,13,"20.4","20.4","20.4","96.146",0,"44.755",559480000,79,"0.314091",1,"7.71037","0.84924","sp|P35869|AHR_HUMAN;tr|E5RGQ2|E5RGQ2_HUMAN;tr|G3V143|G3V143_HUMAN;tr|E5RFG4|E5RFG4_HUMAN;sp|A9YTQ3|AHRR_HUMAN","sp|P35869|AHR_HUMAN",1398,"P35869","AHR_HUMAN","Aryl hydrocarbon receptor","h receptor;hR","AHR"]
["15.6402","16.3724","15.5934",1,{"$nulls":4},"transcription cofactor activity","fibrillar center;SAGA complex",{"$nulls":3},4,4,4,"6.9","6.9","6.9","80.343",0,"29.124",147630000,24,"0.395815",1,"7.70958","1.05526","tr|F6S7C4|F6S7C4_HUMAN;sp|Q8NEM7|SP20H_HUMAN;tr|C9JQS2|C9JQS2_HUMAN;tr|H7C5F9|H7C5F9_HUMAN;tr|B4E2D5|B4E2D5_HUMAN;tr|R4GND2|R4GND2_HUMAN","tr|F6S7C4|F6S7C4_HUMAN;sp|Q8NEM7|SP20H_HUMAN;tr|C9JQS2|C9JQS2_HUMAN;tr|H7C5F9|H7C5F9_HUMAN;tr|B4E2D5|B4E2D5_HUMAN;tr|R4GND2|R4GND2_HUMAN",3326,"F6S7C4","F6S7C4_HUMAN",null,null,"SUPT20H"]
["16.1069","16.9166","16.6045",1,{"$nulls":3},"cardiac muscle thin filament assembly","actin filament binding;cytoskeletal protein binding;filamin binding;structural constituent of muscle;tropomyosin binding","extracellular exosome;I band;stress fiber;Z disc",{"$nulls":3},1,1,1,"1.1","1.1","1.1","116.45","0.00066548","4.0565",37595000,1,"0.368788",1,"7.70948","0.986781","sp|O76041|NEBL_HUMAN","sp|O76041|NEBL_HUMAN",642,"O76041","NEBL_HUMAN","Nebulette",null,"NEBL"]
["15.6304","16.9407","16.1666",1,{"$nulls":3},"defense response to virus;innate immune response;positive regulation of innate immune response;positive regulation of interferon-beta production;positive regulation of type I interferon production;transcription from RNA polymerase III promoter","chromatin binding;DNA binding;DNA-directed 5'-3' RNA polymerase activity","cytosol;DNA-directed RNA polymerase III complex;nuclear chromatin;nuclear speck;nucleoplasm","Cytosolic DNA-sensing pathway;RNA polymerase",null,null,1,1,1,"3.5","3.5","3.5","44.395","0.0010965","3.8869",15365000,3,"0.37873",1,"7.70225","1.01192","sp|P05423|RPC4_HUMAN","sp|P05423|RPC4_HUMAN",865,"P05423","RPC4_HUMAN","DNA-directed RNA polymerase III subunit RPC4","NA polymerase III subunit C4","POLR3D"]
["17.134","17.1537","17.9089",1,{"$nulls":3},"fatty acid alpha-oxidation;protein oligomerization","carbon-carbon lyase activity;cofactor binding;identical protein binding;magnesium ion binding;receptor binding;thiamine pyrophosphate binding","intracellular membrane-bounded organelle;peroxisomal matrix;peroxisome","Peroxisome",null,null,3,3,3,"6.7","6.7","6.7","63.728","0.00023969","5.4756",28730000,4,"0.338105",1,"7.6894","0.909506","sp|Q9UJ83|HACL1_HUMAN;tr|B3KPX4|B3KPX4_HUMAN;tr|C9JJM7|C9JJM7_HUMAN;tr|C9J306|C9J306_HUMAN","sp|Q9UJ83|HACL1_HUMAN;tr|B3KPX4|B3KPX4_HUMAN",4762,"Q9UJ83","HACL1_HUMAN","2-hydroxyacyl-CoA lyase 1",null,"HACL1"]
["16.2643","16.317","16.2259",1,{"$nulls":3},"cell differentiation;spermatogenesis","ubiquitin protein ligase activity","cytoplasm;cytosol;fibrillar center","Ubiquitin mediated proteolysis",null,null,2,2,2,"2.9","2.9","2.9","118.56","0.0013152","3.8833",30657000,5,"0.377379",1,"7.67768","1.0085","sp|Q5GLZ8|HERC4_HUMAN","sp|Q5GLZ8|HERC4_HUMAN",2687,"Q5GLZ8","HERC4_HUMAN","Probable E3 ubiquitin-protein ligase HERC4",null,"HERC4"]
["14.8602","18.6485","17.1706",1,{"$nulls":3},"apoptotic process;cell differentiation;cell proliferation;positive regulation of receptor activity;regulation of apoptotic process;regulation of transcription, DNA-templated;transcription, DNA-templated","ligand-dependent nuclear receptor transcription coactivator activity;RNA binding;transcription coactivator activity","cytoplasm;cytosol;intercellular bridge;intracellular ribonucleoprotein complex;microtubule cytoskeleton;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},2,2,2,"10.2","10.2","10.2","25.673","0.0013043","3.7589",26188000,1,"0.343679",1,"7.66906","0.923517","sp|Q9HD15|SRA1_HUMAN","sp|Q9HD15|SRA1_HUMAN",4338,"Q9HD15","SRA1_HUMAN","Steroid receptor RNA activator 1",null,"SRA1"]
["18.9878","13.7112","16.4412",1,{"$nulls":3},"angiogenesis;inositol phosphate metabolic process;intracellular signal transduction;labyrinthine layer blood vessel development;lipid catabolic process;regulation of cell proliferation","metal ion binding;phosphatidylinositol phospholipase C activity;signal transducer activity","cleavage furrow;cytosol;plasma membrane","AGE-RAGE signaling pathway in diabetic complications;Calcium signaling pathway;Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Thyroid hormone signaling pathway",null,null,19,19,19,"34.3","34.3","34.3","89.257",0,"107.8",1946500000,64,"0.348261",1,"7.62895","0.935042","sp|Q8N3E9|PLCD3_HUMAN;tr|H0YGF8|H0YGF8_HUMAN;tr|F5GXC1|F5GXC1_HUMAN;tr|K7EQF2|K7EQF2_HUMAN","sp|Q8N3E9|PLCD3_HUMAN",3215,"Q8N3E9","PLCD3_HUMAN","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",null,"PLCD3"]
["16.6","18.3036","18.6578",1,{"$nulls":3},"peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase","glutaminyl-peptide cyclotransferase activity;zinc ion binding","Golgi apparatus;Golgi membrane;integral component of membrane;membrane",{"$nulls":3},10,10,10,"37.2","37.2","37.2","42.924",0,"29.415",271500000,37,"0.318148",1,"7.6229","0.859413","sp|Q9NXS2|QPCTL_HUMAN;tr|K7EQG1|K7EQG1_HUMAN","sp|Q9NXS2|QPCTL_HUMAN;tr|K7EQG1|K7EQG1_HUMAN",4553,"Q9NXS2","QPCTL_HUMAN","Glutaminyl-peptide cyclotransferase-like protein",null,"QPCTL"]
["15.3945","16.272","15.437",1,{"$nulls":4},"ATP binding","cytosol;nucleoplasm;plasma membrane",{"$nulls":3},2,2,2,"2.9","2.9","2.9","89.974","0.0031276","3.2095",20981000,1,"0.394908",1,"7.61475","1.05295","tr|A0A0A0MSH9|A0A0A0MSH9_HUMAN;sp|Q86WJ1|CHD1L_HUMAN;tr|A0A087WTM4|A0A087WTM4_HUMAN;tr|A0A0A0MRH8|A0A0A0MRH8_HUMAN","tr|A0A0A0MSH9|A0A0A0MSH9_HUMAN;sp|Q86WJ1|CHD1L_HUMAN;tr|A0A087WTM4|A0A087WTM4_HUMAN;tr|A0A0A0MRH8|A0A0A0MRH8_HUMAN",3072,"A0A0A0MSH9","A0A0A0MSH9_HUMAN",null,null,"CHD1L"]
["16.2364","16.9546","16.9751",1,{"$nulls":3},"peroxisome organization;protein import into peroxisome matrix, translocation;protein stabilization;protein targeting to peroxisome","ATP binding;ATPase activity;ATPase activity, coupled;protein complex binding;protein C-terminus binding","cytoplasm;cytosol;peroxisomal membrane;peroxisome;photoreceptor cell cilium;photoreceptor outer segment","Peroxisome",null,null,1,1,1,"2.7","2.7","2.7","104.06","0.00069332","4.7181",28117000,6,"0.354803",1,"7.60791","0.95151","sp|Q13608|PEX6_HUMAN","sp|Q13608|PEX6_HUMAN",2288,"Q13608","PEX6_HUMAN","Peroxisome assembly factor 2","AF-2","PEX6"]
["16.4004","16.4361","16.6284",1,{"$nulls":3},"calcium-mediated signaling;multicellular organism development","calcium ion binding","cytosol;endoplasmic reticulum;integral component of membrane;membrane;nucleoplasm",{"$nulls":3},13,13,13,"20.7","20.7","20.7","99.594",0,"91.354",565110000,59,"0.363371",1,"7.60408","0.973106","sp|Q6DN12|MCTP2_HUMAN;tr|F5H415|F5H415_HUMAN","sp|Q6DN12|MCTP2_HUMAN",2806,"Q6DN12","MCTP2_HUMAN","Multiple C2 and transmembrane domain-containing protein 2",null,"MCTP2"]
["15.5663","16.8163","16.1771",1,{"$nulls":3},"clathrin coat assembly;clathrin-dependent endocytosis;membrane invagination;membrane organization;protein localization to plasma membrane;synaptic vesicle endocytosis","identical protein binding;phosphatidylinositol binding;phosphatidylinositol-4,5-bisphosphate binding;phosphatidylserine binding","clathrin-coated pit;clathrin-coated vesicle;cytosol;plasma membrane;presynaptic endocytic zone membrane",{"$nulls":3},3,3,3,"5.3","5.3","5.3","88.923","0.00025195","6.518",32244000,9,"0.373421",1,"7.60273","0.998488","sp|Q0JRZ9|FCHO2_HUMAN;tr|H0YAE2|H0YAE2_HUMAN;tr|H7BXJ4|H7BXJ4_HUMAN","sp|Q0JRZ9|FCHO2_HUMAN",2144,"Q0JRZ9","FCHO2_HUMAN","F-BAR domain only protein 2",null,"FCHO2"]
["16.5418","18.1638",1,"18.5096",{"$nulls":3},"cell separation after cytokinesis;endosomal transport;ESCRT III complex disassembly;exit from mitosis;late endosome to vacuole transport;mitotic metaphase plate congression;multivesicular body assembly;nuclear envelope reassembly;nucleus organization;protein localization to chromatin;viral budding via host ESCRT complex;viral life cycle","protein transporter activity","cytosol;ESCRT III complex;nuclear envelope;nucleus","Endocytosis;Necroptosis",null,null,6,6,6,"20.8","20.8","20.8","50.91",0,"21.852",64247000,7,"0.320044",1,"7.598","0.864169","sp|Q8WUX9|CHMP7_HUMAN;tr|E5RJI3|E5RJI3_HUMAN;tr|E5RIU9|E5RIU9_HUMAN","sp|Q8WUX9|CHMP7_HUMAN",3429,"Q8WUX9","CHMP7_HUMAN","Charged multivesicular body protein 7",null,"CHMP7"]
["14.9571","16.2484","15.0147",1,{"$nulls":3},"early endosome to late endosome transport;endosome organization;endosome to lysosome transport;lysosome organization;protein transport",null,"cytosol;FHF complex",{"$nulls":3},2,2,2,"2.8","2.8","2.8","105.57","0.0012995","3.7048",16446000,4,"0.405281",1,"7.59544","1.07936","sp|Q8N612|F16A2_HUMAN","sp|Q8N612|F16A2_HUMAN",3250,"Q8N612","F16A2_HUMAN","FTS and Hook-interacting protein","HIP","FAM160A2"]
["15.6842","16.1059","15.683",1,{"$nulls":4},"nucleic acid binding",{"$nulls":4},1,1,1,"2.1","2.1","2.1","75.56","0.0048603","2.8134",14799000,6,"0.385261",1,"7.55357","1.02846","tr|H0Y5I5|H0Y5I5_HUMAN;tr|F8WCX2|F8WCX2_HUMAN;sp|Q8N1G0|ZN687_HUMAN","tr|H0Y5I5|H0Y5I5_HUMAN;tr|F8WCX2|F8WCX2_HUMAN;sp|Q8N1G0|ZN687_HUMAN",3199,"H0Y5I5","H0Y5I5_HUMAN",null,null,"ZNF687"]
["16.6967","16.2128","16.8193",1,{"$nulls":3},"cell cycle arrest;cell division;eukaryotic translation initiation factor 2 complex assembly;positive regulation of cell proliferation;positive regulation of translational initiation;regulation of translation",null,"cytoplasm",{"$nulls":3},3,3,3,"9.8","9.8","9.8","39.134","0.0013052","3.777",120970000,12,"0.355579",1,"7.54509","0.953464","sp|O75794|CD123_HUMAN;tr|X6RKY7|X6RKY7_HUMAN;tr|X6RF82|X6RF82_HUMAN;tr|X6RA30|X6RA30_HUMAN;tr|H7BZW7|H7BZW7_HUMAN","sp|O75794|CD123_HUMAN;tr|X6RKY7|X6RKY7_HUMAN;tr|X6RF82|X6RF82_HUMAN;tr|X6RA30|X6RA30_HUMAN",611,"O75794","CD123_HUMAN","Cell division cycle protein 123 homolog","rotein D123","CDC123"]
["14.3671","16.6357","14.948",1,{"$nulls":3},"attachment of mitotic spindle microtubules to kinetochore;attachment of spindle microtubules to kinetochore;cell division;chromosome segregation;establishment of mitotic spindle orientation;kinetochore organization;metaphase plate congression;mitotic cell cycle;mitotic sister chromatid segregation;mitotic spindle organization;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of protein localization to kinetochore;sister chromatid cohesion","identical protein binding;structural constituent of cytoskeleton","centrosome;chromosome, centromeric region;condensed chromosome kinetochore;condensed nuclear chromosome outer kinetochore;cytosol;kinetochore;membrane;Ndc80 complex;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"3.3","3.3","3.3","73.912","0.0013146","3.88",12635000,5,"0.399787",1,"7.52742","1.06536","sp|O14777|NDC80_HUMAN","sp|O14777|NDC80_HUMAN",285,"O14777","NDC80_HUMAN","Kinetochore protein NDC80 homolog",null,"NDC80"]
["17.8763","16.0902","17.9129",1,{"$nulls":3},"maturation of SSU-rRNA;negative regulation of phosphatase activity;RNA processing;RNA splicing;RNA splicing, via transesterification reactions;rRNA processing","RNA binding","chromosome;Mpp10 complex;nucleolus;nucleoplasm;small nucleolar ribonucleoprotein complex;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,10,10,10,"22.9","22.9","22.9","78.863",0,"69.817",751800000,71,"0.328402",1,"7.52679","0.885142","sp|O00566|MPP10_HUMAN;tr|U3KQ48|U3KQ48_HUMAN","sp|O00566|MPP10_HUMAN",243,"O00566","MPP10_HUMAN","U3 small nucleolar ribonucleoprotein protein MPP10",null,"MPHOSPH10"]
["15.7248","16.0688","15.7644",1,{"$nulls":3},"activation of MAPKK activity;axon guidance;calcium-mediated signaling;cell migration;cellular response to epidermal growth factor stimulus;epidermal growth factor receptor signaling pathway;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;in utero embryonic development;inositol phosphate metabolic process;leukocyte migration;phospholipid catabolic process;positive regulation of angiogenesis;positive regulation of blood vessel endothelial cell migration;positive regulation of epithelial cell migration;positive regulation of release of sequestered calcium ion into cytosol;signal transduction;T cell receptor signaling pathway;viral process","calcium ion binding;glutamate receptor binding;neurotrophin TRKA receptor binding;phosphatidylinositol phospholipase C activity;phospholipase C activity;protein kinase binding;receptor tyrosine kinase binding;signal transducer activity, downstream of receptor","cell projection;cell-cell junction;COP9 signalosome;cytoplasm;cytosol;lamellipodium;plasma membrane;ruffle","AGE-RAGE signaling pathway in diabetic complications;Axon guidance;Calcium signaling pathway;Choline metabolism in cancer;EGFR tyrosine kinase inhibitor resistance;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glioma;Hepatocellular carcinoma;HIF-1 signaling pathway;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Inositol phosphate metabolism;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Metabolic pathways;MicroRNAs in cancer;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;NF-kappa B signaling pathway;Non-small cell lung cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid hormone signaling pathway;VEGF signaling pathway;Vibrio cholerae infection;Yersinia infection",null,null,4,4,4,"5.2","5.2","5.2","148.53","0.00026247","7.4075",29975000,7,"0.380995",1,"7.51456","1.01765","sp|P19174|PLCG1_HUMAN","sp|P19174|PLCG1_HUMAN",1128,"P19174","PLCG1_HUMAN","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1",null,"PLCG1"]
["17.3036","16.244","17.5236",1,{"$nulls":3},"mitotic cell cycle checkpoint;regulation of exit from mitosis",null,"cytoplasm;nuclear membrane;nucleolus;nucleus;spindle",{"$nulls":3},2,2,2,"8.8","8.8","8.8","31.051","0.0048524","2.7798",13786000,3,"0.337258",1,"7.51198","0.90738","sp|Q15013|MD2BP_HUMAN","sp|Q15013|MD2BP_HUMAN",2422,"Q15013","MD2BP_HUMAN","MAD2L1-binding protein",null,"MAD2L1BP"]
["18.8567","16.7378","19.5744",1,{"$nulls":3},"cell redox homeostasis;oxidation-reduction process;protein folding;response to endoplasmic reticulum stress","protein disulfide isomerase activity","endoplasmic reticulum;integral component of membrane",{"$nulls":3},3,3,3,"11.5","11.5","11.5","38.952","0.00026882","7.9462",44090000,6,"0.295821",1,"7.51008","0.80344","sp|Q9H1E5|TMX4_HUMAN","sp|Q9H1E5|TMX4_HUMAN",4155,"Q9H1E5","TMX4_HUMAN","Thioredoxin-related transmembrane protein 4",null,"TMX4"]
["16.3131","17.4675","17.7919",1,{"$nulls":3},"signal transduction","phosphatase regulator activity;protein kinase binding","cytoplasm","Focal adhesion;Oxytocin signaling pathway;Proteoglycans in cancer;Regulation of actin cytoskeleton;Vascular smooth muscle contraction",null,null,21,21,2,"35.9","35.9","3.5","84.88",0,"83.107",624560000,102,"0.330545",1,"7.49439","0.890519","sp|Q9BZL4|PP12C_HUMAN","sp|Q9BZL4|PP12C_HUMAN",4084,"Q9BZL4","PP12C_HUMAN","Protein phosphatase 1 regulatory subunit 12C",null,"PPP1R12C"]
["16.6221","16.5824","17.2792",1,{"$nulls":3},"cell adhesion;cell-cell signaling;negative regulation of cell proliferation;neutrophil degranulation;regulation of immune response;signal transduction","carbohydrate binding;receptor activity","external side of plasma membrane;extracellular exosome;integral component of plasma membrane;nucleus;plasma membrane;specific granule membrane;tertiary granule membrane","Hematopoietic cell lineage",null,null,1,1,1,"3.3","3.3","3.3","39.825","0.00069573","4.8095",16053000,3,"0.34102",1,"7.46267","0.916832","sp|P20138|CD33_HUMAN","sp|P20138|CD33_HUMAN",1144,"P20138","CD33_HUMAN","Myeloid cell surface antigen CD33",null,"CD33"]
["17.434","15.9127","17.4218",1,{"$nulls":3},"cell proliferation;mitotic chromosome movement towards spindle pole;positive regulation of mitotic metaphase/anaphase transition;protein complex assembly;signaling","phosphoprotein phosphatase activity","cytosol;microtubule organizing center;mitochondrion;nucleus;spindle pole centrosome",{"$nulls":3},7,7,7,"12.4","12.4","12.4","95.114",0,"16.871",61900000,12,"0.336299",1,"7.46242","0.90497","sp|Q15398|DLGP5_HUMAN;tr|G3V543|G3V543_HUMAN;tr|G3V4E5|G3V4E5_HUMAN","sp|Q15398|DLGP5_HUMAN",2485,"Q15398","DLGP5_HUMAN","Disks large-associated protein 5","AP-5","DLGAP5"]
["16.9981","16.7597",1,"17.8371",{"$nulls":3},"enzyme-directed rRNA 2'-O-methylation;rRNA 2'-O-methylation","RNA binding;rRNA (guanosine-2'-O-)-methyltransferase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},2,2,2,"6.5","6.5","6.5","38.638","0.0013129","3.8554",18595000,2,"0.328779",1,"7.46033","0.886086","sp|Q6IN84|MRM1_HUMAN;tr|A0A087WZC1|A0A087WZC1_HUMAN","sp|Q6IN84|MRM1_HUMAN;tr|A0A087WZC1|A0A087WZC1_HUMAN",2821,"Q6IN84","MRM1_HUMAN","rRNA methyltransferase 1, mitochondrial {ECO:0000303|PubMed:24036117}",null,"MRM1"]
["15.1875","15.5099",1,"14.7847",{"$nulls":3},"activation of JUN kinase activity;activation of protein kinase activity;apoptotic process;axial mesoderm formation;beta-catenin destruction complex assembly;beta-catenin destruction complex disassembly;canonical Wnt signaling pathway;canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation;cellular protein complex assembly;cytoplasmic microtubule organization;determination of left/right symmetry;embryonic eye morphogenesis;embryonic skeletal joint morphogenesis;forebrain anterior/posterior pattern specification;muscle cell development;negative regulation of canonical Wnt signaling pathway;negative regulation of fat cell differentiation;negative regulation of transcription elongation from RNA polymerase II promoter;negative regulation of Wnt signaling pathway;olfactory placode formation;optic placode formation;positive regulation of canonical Wnt signaling pathway;positive regulation of JNK cascade;positive regulation of peptidyl-serine phosphorylation;positive regulation of peptidyl-threonine phosphorylation;positive regulation of protein catabolic process;positive regulation of protein phosphorylation;positive regulation of protein ubiquitination;positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;positive regulation of transcription, DNA-templated;positive regulation of ubiquitin-protein transferase activity;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;regulation of intracellular estrogen receptor signaling pathway;regulation of Wnt signaling pathway;Wnt signaling pathway;Wnt-activated signaling pathway involved in forebrain neuron fate commitment","armadillo repeat domain binding;beta-catenin binding;enzyme binding;GTPase activator activity;identical protein binding;I-SMAD binding;protein complex scaffold activity;protein homodimerization activity;protein kinase binding;receptor signaling complex scaffold activity;signal transducer activity;SMAD binding;ubiquitin protein ligase binding","beta-catenin destruction complex;cell periphery;cytoplasm;cytoplasmic vesicle;cytosol;lateral plasma membrane;nucleus;perinuclear region of cytoplasm","Basal cell carcinoma;Breast cancer;Colorectal cancer;Cushing syndrome;Endometrial cancer;Gastric cancer;Hepatocellular carcinoma;Hippo signaling pathway;Human papillomavirus infection;Pathways in cancer;Signaling pathways regulating pluripotency of stem cells;Wnt signaling pathway",null,null,1,1,1,"1.7","1.7","1.7","95.634","0.00087951","3.9389",42053000,13,"0.406135",1,"7.45634","1.08153","sp|O15169|AXIN1_HUMAN","sp|O15169|AXIN1_HUMAN",337,"O15169","AXIN1_HUMAN","Axin-1",null,"AXIN1"]
["15.9609","16.4017","16.4818",1,{"$nulls":3},"small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity","intracellular",{"$nulls":3},4,4,4,"4.9","4.9","4.9","126.41",0,"8.2938",46218000,5,"0.358484",1,"7.44036","0.960783","tr|D6RE77|D6RE77_HUMAN;tr|A0A0A6YYB7|A0A0A6YYB7_HUMAN;tr|A0A0A0MR23|A0A0A0MR23_HUMAN;sp|Q8TEU7|RPGF6_HUMAN;tr|E9PCH4|E9PCH4_HUMAN;tr|B7Z7Y1|B7Z7Y1_HUMAN;tr|A0A0A6YYJ1|A0A0A6YYJ1_HUMAN","tr|D6RE77|D6RE77_HUMAN;tr|A0A0A6YYB7|A0A0A6YYB7_HUMAN;tr|A0A0A0MR23|A0A0A0MR23_HUMAN;sp|Q8TEU7|RPGF6_HUMAN;tr|E9PCH4|E9PCH4_HUMAN;tr|B7Z7Y1|B7Z7Y1_HUMAN",3400,"D6RE77","D6RE77_HUMAN",null,null,"RAPGEF6"]
["16.3708","16.2241","16.7168",1,{"$nulls":3},"apoptotic process;blastocyst formation;blood coagulation;camera-type eye morphogenesis;macroautophagy;mitochondrial fusion;mitochondrial membrane organization;mitochondrion localization;negative regulation of Ras protein signal transduction;negative regulation of smooth muscle cell proliferation;parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization;protein localization to phagophore assembly site;protein targeting to mitochondrion;response to unfolded protein","GTP binding;GTPase activity;ubiquitin protein ligase binding","cytosol;integral component of membrane;intrinsic component of mitochondrial outer membrane;microtubule cytoskeleton;mitochondrial outer membrane;mitochondrion","Mitophagy - animal;NOD-like receptor signaling pathway",null,null,5,5,5,"10.3","10.3","10.3","86.401",0,"8.077",54586000,10,"0.352852",1,"7.43905","0.946596","sp|O95140|MFN2_HUMAN;tr|Q5JXC5|Q5JXC5_HUMAN;tr|C9JQT7|C9JQT7_HUMAN;tr|H7C5H5|H7C5H5_HUMAN;tr|A0A0C4DFN1|A0A0C4DFN1_HUMAN;sp|Q8IWA4|MFN1_HUMAN","sp|O95140|MFN2_HUMAN",692,"O95140","MFN2_HUMAN","Mitofusin-2",null,"MFN2"]
["16.2358","18.3578",1,"18.7241",{"$nulls":3},"axon guidance;MAPK cascade;microtubule nucleation;negative regulation of ERK1 and ERK2 cascade;protein complex assembly","enzyme binding;Ran GTPase binding;Ras guanyl-nucleotide exchange factor activity","cytoplasm;cytosol;microtubule associated complex;nucleus;plasma membrane",{"$nulls":3},4,4,4,"8.1","8.1","8.1","77.846",0,"8.5334",43768000,6,"0.307609",1,"7.43472","0.83299","sp|Q96S59|RANB9_HUMAN","sp|Q96S59|RANB9_HUMAN",3814,"Q96S59","RANB9_HUMAN","Ran-binding protein 9","anBP9","RANBP9"]
["14.9621","15.9719","15.0823",1,{"$nulls":3},"negative regulation of transcription, DNA-templated;regulation of DNA methylation;transcription, DNA-templated","methylated histone binding;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;nuclear heterochromatin;nuclear nucleosome;nucleolus;nucleus;plasma membrane;ubiquitin ligase complex",{"$nulls":3},3,3,3,8,8,8,"97.181",0,"10.096",55418000,18,"0.39451",1,"7.42587","1.05194","sp|Q99549|MPP8_HUMAN;tr|A0A0A0MT47|A0A0A0MT47_HUMAN","sp|Q99549|MPP8_HUMAN",3856,"Q99549","MPP8_HUMAN","M-phase phosphoprotein 8",null,"MPHOSPH8"]
["15.7342","15.7566","15.6435",1,{"$nulls":3},"signal transduction","GTP binding;GTPase activity",{"$nulls":4},6,6,6,"5.7","5.7","5.7","171.68",0,"13.762",42050000,15,"0.379516",1,"7.42361","1.01391","tr|A0A0A0MSK6|A0A0A0MSK6_HUMAN;sp|Q13017|RHG05_HUMAN","tr|A0A0A0MSK6|A0A0A0MSK6_HUMAN;sp|Q13017|RHG05_HUMAN",2194,"A0A0A0MSK6","A0A0A0MSK6_HUMAN",null,null,"ARHGAP5"]
["16.1181","16.2535","16.526",1,{"$nulls":3},"protein complex assembly;signaling","protein domain specific binding","plasma membrane;synapse",{"$nulls":3},3,3,3,4,4,4,"108.01","0.00024038","5.517",33963000,3,"0.356641",1,"7.42279","0.956141","sp|Q9Y2H0|DLGP4_HUMAN;tr|F8WF49|F8WF49_HUMAN;tr|A0A0B4J2C2|A0A0B4J2C2_HUMAN","sp|Q9Y2H0|DLGP4_HUMAN",4914,"Q9Y2H0","DLGP4_HUMAN","Disks large-associated protein 4","AP-4","DLGAP4"]
["18.2065","16.0355","18.4223",1,{"$nulls":3},"defense response to virus;immune response","ATP binding;double-stranded RNA binding;nucleotidyltransferase activity","cytosol",{"$nulls":3},2,2,2,"9.4","9.4","9.4","41.474","0.0015132","3.6636",29327000,1,"0.312038",1,"7.40987","0.844093","tr|F8VXY3|F8VXY3_HUMAN;sp|P00973|OAS1_HUMAN;tr|H0YIB8|H0YIB8_HUMAN;tr|H0YI20|H0YI20_HUMAN","tr|F8VXY3|F8VXY3_HUMAN;sp|P00973|OAS1_HUMAN;tr|H0YIB8|H0YIB8_HUMAN;tr|H0YI20|H0YI20_HUMAN",811,"F8VXY3","F8VXY3_HUMAN",null,null,"OAS1"]
["16.0056","16.1539","16.3502",1,{"$nulls":3},"aging;angiogenesis involved in wound healing;axon regeneration;basement membrane organization;branching involved in salivary gland morphogenesis;calcium-dependent cell-matrix adhesion;cellular response to cholesterol;cellular response to mechanical stimulus;commissural neuron axon guidance;cytoskeletal anchoring at plasma membrane;epithelial tube branching involved in lung morphogenesis;extracellular matrix organization;membrane protein ectodomain proteolysis;microtubule anchoring;modulation by virus of host morphology or physiology;morphogenesis of an epithelial sheet;myelination in peripheral nervous system;negative regulation of cell migration;negative regulation of MAPK cascade;negative regulation of protein kinase B signaling;nerve maturation;NLS-bearing protein import into nucleus;positive regulation of basement membrane assembly involved in embryonic body morphogenesis;positive regulation of cell-matrix adhesion;positive regulation of myelination;positive regulation of oligodendrocyte differentiation;positive regulation of protein kinase activity;protein O-linked glycosylation;regulation of embryonic cell shape;regulation of epithelial to mesenchymal transition;regulation of gastrulation;response to denervation involved in regulation of muscle adaptation;response to peptide hormone;skeletal muscle tissue regeneration","actin binding;alpha-actinin binding;calcium ion binding;dystroglycan binding;laminin-1 binding;SH2 domain binding;structural constituent of muscle;tubulin binding;vinculin binding;virus receptor activity","basement membrane;basolateral plasma membrane;cell-cell adherens junction;contractile ring;costamere;cytoplasm;cytoskeleton;cytosol;dystroglycan complex;dystrophin-associated glycoprotein complex;endoplasmic reticulum lumen;external side of plasma membrane;extracellular exosome;extracellular matrix;extracellular region;extracellular space;filopodium;focal adhesion;Golgi lumen;integral component of membrane;lamellipodium;node of Ranvier;nuclear periphery;nucleoplasm;plasma membrane;plasma membrane raft;postsynaptic membrane;sarcolemma","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);ECM-receptor interaction;Hypertrophic cardiomyopathy (HCM);Viral myocarditis",null,null,3,3,3,"4.6","4.6","4.6","97.44","0.00025426","6.7165",27623000,4,"0.360045",1,"7.40467","0.96472","sp|Q14118|DAG1_HUMAN","sp|Q14118|DAG1_HUMAN",2328,"Q14118","DAG1_HUMAN","Dystroglycan",null,"DAG1"]
["14.0519","16.3642",1,"14.7099",{"$nulls":3},"brain development",null,"axon;integral component of membrane;neuron projection terminus;nuclear membrane;nucleus;rough endoplasmic reticulum membrane;synapse",{"$nulls":3},10,10,10,"20.5","20.5","20.5","76.177",0,"17.312",198140000,28,"0.396785",1,"7.35306","1.05772","sp|Q8N5G2|MACOI_HUMAN","sp|Q8N5G2|MACOI_HUMAN",3240,"Q8N5G2","MACOI_HUMAN","Macoilin {ECO:0000303|PubMed:21589894}",null,"MACO1"]
["15.8672","16.1955","16.3612",1,{"$nulls":3},"transport","ATP binding;ATPase activity, coupled to transmembrane movement of substances;transporter activity","ATP-binding cassette (ABC) transporter complex;membrane;mitochondrial envelope;mitochondrial inner membrane;mitochondrion;nucleolus;nucleus","ABC transporters",null,null,2,2,2,"4.8","4.8","4.8","79.988","0.00024131","5.608",32336000,8,"0.35692",1,"7.35079","0.956842","sp|Q9NUT2|ABCB8_HUMAN","sp|Q9NUT2|ABCB8_HUMAN",4473,"Q9NUT2","ABCB8_HUMAN","ATP-binding cassette sub-family B member 8, mitochondrial",null,"ABCB8"]
["15.6769","15.8279","15.8141",1,{"$nulls":3},"cellular glucose homeostasis;cellular response to insulin stimulus;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;insulin receptor signaling pathway;interleukin-7-mediated signaling pathway;leukocyte migration;negative regulation of MAPK cascade;phosphatidylinositol 3-kinase signaling;phosphatidylinositol biosynthetic process;phosphatidylinositol phosphorylation;phosphatidylinositol-mediated signaling;positive regulation of glucose import in response to insulin stimulus;positive regulation of protein kinase B signaling;positive regulation of transcription factor import into nucleus;positive regulation of transcription from RNA polymerase II promoter;protein transport;regulation of autophagy;regulation of phosphatidylinositol 3-kinase activity;regulation of small GTPase mediated signal transduction;response to endoplasmic reticulum stress;T cell receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway","1-phosphatidylinositol-3-kinase activity;1-phosphatidylinositol-3-kinase regulator activity;GTPase activator activity;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;phosphotyrosine residue binding;protein heterodimerization activity;protein phosphatase binding;receptor tyrosine kinase binding","cytosol;nucleus;phosphatidylinositol 3-kinase complex","Acute myeloid leukemia;AGE-RAGE signaling pathway in diabetic complications;Aldosterone-regulated sodium reabsorption;Amoebiasis;AMPK signaling pathway;Apoptosis;Autophagy - animal;Axon guidance;B cell receptor signaling pathway;Bacterial invasion of epithelial cells;Breast cancer;cAMP signaling pathway;Carbohydrate digestion and absorption;Cellular senescence;Central carbon metabolism in cancer;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;C-type lectin receptor signaling pathway;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;Epstein-Barr virus infection;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Insulin signaling pathway;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Longevity regulating pathway;Longevity regulating pathway - multiple species;Measles;Melanoma;MicroRNAs in cancer;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Non-small cell lung cancer;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Platelet activation;Platinum drug resistance;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Signaling pathways regulating pluripotency of stem cells;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid hormone signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Type II diabetes mellitus;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,2,2,2,"4.1","4.1","4.1","81.544","0.00088009","3.949",14875000,3,"0.370707",1,"7.34539","0.991627","sp|O00459|P85B_HUMAN;tr|E9PFP1|E9PFP1_HUMAN","sp|O00459|P85B_HUMAN;tr|E9PFP1|E9PFP1_HUMAN",228,"O00459","P85B_HUMAN","Phosphatidylinositol 3-kinase regulatory subunit beta","I3K regulatory subunit beta;I3-kinase regulatory subunit beta;tdIns-3-kinase regulatory subunit beta","PIK3R2"]
["16.2176","16.6018",1,"17.1339",{"$nulls":3},"7-methylguanosine mRNA capping;DNA repair;global genome nucleotide-excision repair;nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;phosphorylation of RNA polymerase II C-terminal domain;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair","ATP-dependent DNA helicase activity;DNA binding transcription factor activity;double-stranded DNA binding","core TFIIH complex portion of holo TFIIH complex;holo TFIIH complex;nuclear speck;nucleoplasm;nucleus;transcription factor TFIID complex","Basal transcription factors;Nucleotide excision repair;Viral carcinogenesis",null,null,7,7,7,21,21,21,"52.186",0,"47.783",461520000,56,"0.338289",1,"7.34275","0.909968","sp|Q92759|TF2H4_HUMAN;tr|A0A0G2JHJ2|A0A0G2JHJ2_HUMAN","sp|Q92759|TF2H4_HUMAN",3525,"Q92759","TF2H4_HUMAN","General transcription factor IIH subunit 4",null,"GTF2H4"]
["15.4971","17.0721",1,"16.8864",{"$nulls":3},"cellular glucuronidation;coumarin metabolic process;drug metabolic process;fatty acid metabolic process;flavone metabolic process;flavonoid glucuronidation;negative regulation of cellular glucuronidation;negative regulation of fatty acid metabolic process;negative regulation of glucuronosyltransferase activity;negative regulation of steroid metabolic process;retinoic acid metabolic process;steroid metabolic process;xenobiotic glucuronidation","drug binding;enzyme binding;enzyme inhibitor activity;fatty acid binding;glucuronosyltransferase activity;protein heterodimerization activity;protein homodimerization activity;retinoic acid binding;steroid binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Ascorbate and aldarate metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pentose and glucuronate interconversions;Porphyrin and chlorophyll metabolism;Retinol metabolism;Steroid hormone biosynthesis",null,null,10,1,1,"33.2","2.1","2.1","59.741","0.0013075","3.8109",58063000,3,"0.34217",1,"7.34137","0.919723","sp|Q9HAW9|UD18_HUMAN;sp|Q9HAW7|UD17_HUMAN;sp|O60656|UD19_HUMAN;tr|H0Y8D7|H0Y8D7_HUMAN","sp|Q9HAW9|UD18_HUMAN;sp|Q9HAW7|UD17_HUMAN;sp|O60656|UD19_HUMAN",4300,"Q9HAW9","UD18_HUMAN","UDP-glucuronosyltransferase 1-8","DPGT 1-8;GT1*8;GT1.8;GT1-08","UGT1A8"]
["17.7041","16.1465","18.1842",1,{"$nulls":3},"cellular glucuronidation;steroid metabolic process","glucuronosyltransferase activity","endoplasmic reticulum membrane;integral component of membrane;intracellular membrane-bounded organelle;membrane;organelle membrane","Ascorbate and aldarate metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pentose and glucuronate interconversions;Porphyrin and chlorophyll metabolism;Retinol metabolism;Steroid hormone biosynthesis",null,null,4,4,4,"7.5","7.5","7.5","61.095","0.00067416","4.2189",72621000,10,"0.314391",1,"7.33318","0.849994","sp|O75795|UDB17_HUMAN;sp|P54855|UDB15_HUMAN;tr|A0A0G2JMZ5|A0A0G2JMZ5_HUMAN;sp|P36537|UDB10_HUMAN;tr|A0A087WYG9|A0A087WYG9_HUMAN;sp|Q9BY64|UDB28_HUMAN","sp|O75795|UDB17_HUMAN;sp|P54855|UDB15_HUMAN",612,"O75795","UDB17_HUMAN","UDP-glucuronosyltransferase 2B17","DPGT 2B17","UGT2B17"]
["15.8758","15.8676","16.0852",1,{"$nulls":3},"cell-cell junction organization;sensory perception of sound",null,"cell junction;integral component of membrane;tricellular tight junction",{"$nulls":3},2,2,2,"6.8","6.8","6.8","51.12","0.0066969","2.5155",11948000,3,"0.362812",1,"7.3291","0.971697","tr|A1BQX2|A1BQX2_HUMAN;tr|A0A0G2JQ38|A0A0G2JQ38_HUMAN;tr|D6RA09|D6RA09_HUMAN;tr|A0A0G2JN23|A0A0G2JN23_HUMAN;sp|Q8N4S9|MALD2_HUMAN;tr|D6RAH8|D6RAH8_HUMAN;tr|A0A0G2JN00|A0A0G2JN00_HUMAN","tr|A1BQX2|A1BQX2_HUMAN;tr|A0A0G2JQ38|A0A0G2JQ38_HUMAN;tr|D6RA09|D6RA09_HUMAN;tr|A0A0G2JN23|A0A0G2JN23_HUMAN;sp|Q8N4S9|MALD2_HUMAN;tr|D6RAH8|D6RAH8_HUMAN;tr|A0A0G2JN00|A0A0G2JN00_HUMAN",3227,"A1BQX2","A1BQX2_HUMAN"]
["15.7316","17.2425",1,"17.3203",{"$nulls":4},"phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"4.9","4.9","4.9","56.447","0.0088786","2.2708",15298000,1,"0.331954",1,"7.32685","0.894057","sp|Q9ULR3|PPM1H_HUMAN","sp|Q9ULR3|PPM1H_HUMAN",4823,"Q9ULR3","PPM1H_HUMAN","Protein phosphatase 1H",null,"PPM1H"]
["18.8601","16.0315","19.2613",1,{"$nulls":3},"cellular response to glucagon stimulus;cerebral cortex development;G-protein coupled receptor signaling pathway;response to lipopolysaccharide;signal transduction","PDZ domain binding;phosphate ion binding;signal transducer activity","actin filament;extracellular exosome;heterotrimeric G-protein complex;plasma membrane","Alcoholism;Apelin signaling pathway;Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Dopaminergic synapse;GABAergic synapse;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;MAPK signaling pathway;Morphine addiction;Pathways in cancer;PI3K-Akt signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Retrograde endocannabinoid signaling;Serotonergic synapse",null,null,1,1,1,"15.3","15.3","15.3","8.0061","0.0017116","3.5138",11153000,4,"0.291149",1,"7.31519","0.791727","sp|Q9UBI6|GBG12_HUMAN","sp|Q9UBI6|GBG12_HUMAN",4664,"Q9UBI6","GBG12_HUMAN","Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12",null,"GNG12"]
["17.544","15.9758","17.9505",1,{"$nulls":3},"apoptotic process;cellular response to virus;mRNA processing;negative regulation of GTPase activity;negative regulation of phosphatase activity;positive regulation by host of viral transcription;positive regulation of apoptotic process;positive regulation of transcription from RNA polymerase II promoter;regulation of RNA splicing;RNA splicing;rRNA processing","RNA binding;RNA polymerase II transcription coactivator activity","cytosol;euchromatin;granular component;heterochromatin;nucleolus;nucleoplasm;nucleus;preribosome, large subunit precursor;preribosome, small subunit precursor",{"$nulls":3},19,19,19,"36.5","36.5","36.5","84.427",0,"93.734",1006200000,95,"0.316733",1,"7.28464","0.855865","sp|Q14684|RRP1B_HUMAN","sp|Q14684|RRP1B_HUMAN",2381,"Q14684","RRP1B_HUMAN","Ribosomal RNA processing protein 1 homolog B",null,"RRP1B"]
["15.3396","13.8663",1,"13.6606",{"$nulls":3},"cell cycle;positive regulation of cell cycle;positive regulation of cell proliferation;positive regulation of transcription from RNA polymerase II promoter;regulation of Rho guanyl-nucleotide exchange factor activity",null,"integral component of membrane",{"$nulls":3},6,6,6,9,9,9,"87.339",0,"21.094",245540000,40,"0.429433",1,"7.2727","1.14117","sp|Q9ULG6|CCPG1_HUMAN;tr|H3BNE2|H3BNE2_HUMAN;tr|H3BV63|H3BV63_HUMAN","sp|Q9ULG6|CCPG1_HUMAN",4815,"Q9ULG6","CCPG1_HUMAN","Cell cycle progression protein 1",null,"CCPG1"]
["15.9338","17.4672",1,"17.8655",{"$nulls":3},"cellular response to oxidative stress;peptidyl-serine phosphorylation;protein autophosphorylation;protein phosphorylation;regulation of cell shape;regulation of interleukin-1-mediated signaling pathway;regulation of MAPK cascade;viral process","ATP binding;protein domain specific binding;protein kinase binding;protein serine/threonine kinase activity","cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;mitochondrial membrane;nucleus;protein complex",{"$nulls":3},12,12,12,"32.5","32.5","32.5","58.14",0,"49.814",392970000,57,"0.317707",1,"7.26776","0.858309","sp|Q86Y07|VRK2_HUMAN;tr|E7ERS5|E7ERS5_HUMAN;tr|E9PBU1|E9PBU1_HUMAN","sp|Q86Y07|VRK2_HUMAN",3088,"Q86Y07","VRK2_HUMAN","Serine/threonine-protein kinase VRK2",null,"VRK2"]
["15.5202","15.9618","15.9559",1,{"$nulls":3},"aging;anatomical structure morphogenesis;antral ovarian follicle growth;brain morphogenesis;cellular response to amyloid-beta;cellular response to corticosterone stimulus;cellular response to glucose stimulus;cellular response to hypoxia;cellular response to nerve growth factor stimulus;cellular response to oxidative stress;DNA damage response, signal transduction by p53 class mediator;extrinsic apoptotic signaling pathway in absence of ligand;initiation of primordial ovarian follicle growth;negative regulation of canonical Wnt signaling pathway;negative regulation of neuron differentiation;negative regulation of transcription from RNA polymerase II promoter;neuronal stem cell population maintenance;oocyte maturation;ovulation from ovarian follicle;positive regulation of apoptotic process;positive regulation of endothelial cell apoptotic process;positive regulation of erythrocyte differentiation;positive regulation of hydrogen peroxide-mediated programmed cell death;positive regulation of neuron apoptotic process;positive regulation of reactive oxygen species biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;protein kinase B signaling;regulation of neural precursor cell proliferation;regulation of transcription from RNA polymerase II promoter;regulation of translation;response to dexamethasone;response to drug;response to nutrient levels;response to water-immersion restraint stress;tumor necrosis factor-mediated signaling pathway","beta-catenin binding;chromatin DNA binding;core promoter binding;DNA binding;DNA binding transcription factor activity;protein kinase binding;sequence-specific DNA binding;transcription cofactor binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytoplasm;cytosol;membrane;mitochondrion;nucleoplasm;nucleus","AMPK signaling pathway;Cellular senescence;Chemokine signaling pathway;EGFR tyrosine kinase inhibitor resistance;Endometrial cancer;FoxO signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Mitophagy - animal;Neurotrophin signaling pathway;Non-small cell lung cancer;PI3K-Akt signaling pathway;Prolactin signaling pathway",null,null,1,1,1,"2.8","2.8","2.8","71.276","0.005988","2.6476",9702800,2,"0.362469",1,"7.26302","0.970832","sp|O43524|FOXO3_HUMAN","sp|O43524|FOXO3_HUMAN",407,"O43524","FOXO3_HUMAN","Forkhead box protein O3 {ECO:0000305}",null,"FOXO3"]
["17.4032","17.2551","19.2087",1,{"$nulls":4},"DNA binding transcription factor activity","cytosol;nucleus",{"$nulls":3},2,2,2,17,17,17,"31.356","0.0068816","2.4943",20060000,5,"0.291866",1,"7.22475","0.793523","tr|B1AJU4|B1AJU4_HUMAN;sp|O14896|IRF6_HUMAN","tr|B1AJU4|B1AJU4_HUMAN;sp|O14896|IRF6_HUMAN",296,"B1AJU4","B1AJU4_HUMAN",null,null,"IRF6"]
["16.2352","17.0366",1,"17.8551",{"$nulls":9},10,10,10,"34.4","34.4","34.4","41.21",0,"17.791",193050000,30,"0.316134",1,"7.20834","0.854363","tr|A0A087WZ32|A0A087WZ32_HUMAN;tr|A8K727|A8K727_HUMAN;sp|Q9HB19|PKHA2_HUMAN;tr|A0A087X038|A0A087X038_HUMAN;tr|E5RHB5|E5RHB5_HUMAN;tr|E5RGP3|E5RGP3_HUMAN","tr|A0A087WZ32|A0A087WZ32_HUMAN;tr|A8K727|A8K727_HUMAN;sp|Q9HB19|PKHA2_HUMAN;tr|A0A087X038|A0A087X038_HUMAN;tr|E5RHB5|E5RHB5_HUMAN",5133,"A0A087WZ32","A0A087WZ32_HUMAN",null,null,"PLEKHA2"]
["16.9187","15.773","17.2937",1,{"$nulls":4},"enzyme binding",{"$nulls":4},4,4,4,"7.5","7.5","7.5","73.2",0,"8.6541",32547000,10,"0.326942",1,"7.199","0.881476","sp|Q9NW82|WDR70_HUMAN;tr|D6RIW8|D6RIW8_HUMAN","sp|Q9NW82|WDR70_HUMAN;tr|D6RIW8|D6RIW8_HUMAN",4512,"Q9NW82","WDR70_HUMAN","WD repeat-containing protein 70",null,"WDR70"]
["17.517","16.163","18.2962",1,{"$nulls":3},"autophagosome assembly;cellular response to starvation;positive regulation of autophagosome assembly;positive regulation of vacuole organization","RNA binding","extracellular exosome;Golgi apparatus;integral component of plasma membrane;late endosome membrane;lysosomal membrane;plasma membrane",{"$nulls":3},3,3,3,"3.4","3.4","3.4","111.38",0,"10.831",64282000,4,"0.30605",1,"7.1919","0.829081","sp|Q6UXG2|K1324_HUMAN;tr|E9PB18|E9PB18_HUMAN","sp|Q6UXG2|K1324_HUMAN;tr|E9PB18|E9PB18_HUMAN",2911,"Q6UXG2","K1324_HUMAN","UPF0577 protein KIAA1324",null,"KIAA1324"]
["15.0163","15.4693",1,"15.1061",{"$nulls":3},"regulation of small GTPase mediated signal transduction","GTPase activator activity","cytosol;nucleus;plasma membrane",{"$nulls":3},5,4,4,"3.2","2.8","2.8","194.93","0.00046696","4.8939",35534000,8,"0.381472",1,"7.18977","1.01886","tr|H7C1F9|H7C1F9_HUMAN;sp|Q2PPJ7|RGPA2_HUMAN","tr|H7C1F9|H7C1F9_HUMAN;sp|Q2PPJ7|RGPA2_HUMAN",2598,"H7C1F9","H7C1F9_HUMAN",null,null,"RALGAPA2"]
["15.6648","15.7435","16.0477",1,{"$nulls":3},"intracellular signal transduction;regulation of Rho protein signal transduction","Rho guanyl-nucleotide exchange factor activity","cytosol;nucleoplasm;plasma membrane",{"$nulls":3},4,4,4,"5.8","5.8","5.8","89.123",0,"8.7754",36165000,6,"0.355921",1,"7.18032","0.954327","tr|H0Y895|H0Y895_HUMAN;sp|Q12774|ARHG5_HUMAN;tr|C9J591|C9J591_HUMAN","tr|H0Y895|H0Y895_HUMAN;sp|Q12774|ARHG5_HUMAN",2156,"H0Y895","H0Y895_HUMAN",null,null,"ARHGEF5"]
["14.9399","15.9482","15.536",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},9,9,9,"10.2","10.2","10.2","125.38",0,"28.528",200340000,35,"0.368073",1,"7.17601","0.984974","tr|A0A087WVA8|A0A087WVA8_HUMAN;sp|Q8IWB9|TEX2_HUMAN;tr|J3KRZ8|J3KRZ8_HUMAN","tr|A0A087WVA8|A0A087WVA8_HUMAN;sp|Q8IWB9|TEX2_HUMAN;tr|J3KRZ8|J3KRZ8_HUMAN",3125,"A0A087WVA8","A0A087WVA8_HUMAN",null,null,"TEX2"]
["15.2749","17.8491",1,"17.7906",{"$nulls":3},"intracellular protein transport;vesicle-mediated transport",null,"intracellular",{"$nulls":3},3,3,3,"10.5","10.5","10.5","55.361","0.00067431","4.2193",15890000,2,"0.311918",1,"7.16667","0.843792","tr|A0A0G2JS92|A0A0G2JS92_HUMAN;tr|B7Z879|B7Z879_HUMAN;tr|A0A087WXL6|A0A087WXL6_HUMAN;sp|Q9H270|VPS11_HUMAN","tr|A0A0G2JS92|A0A0G2JS92_HUMAN;tr|B7Z879|B7Z879_HUMAN;tr|A0A087WXL6|A0A087WXL6_HUMAN;sp|Q9H270|VPS11_HUMAN",4164,"A0A0G2JS92","A0A0G2JS92_HUMAN",null,null,"VPS11"]
["17.1138","15.4905","17.271",1,{"$nulls":3},"fatty acid alpha-oxidation;fatty acid biosynthetic process;oxidation-reduction process;phytol metabolic process","receptor binding;trans-2-enoyl-CoA reductase (NADPH) activity","mitochondrion;peroxisomal membrane;peroxisome","Peroxisome",null,null,5,5,5,29,29,29,"32.544",0,"19.935",135470000,19,"0.324983",1,"7.16666","0.876559","sp|Q9BY49|PECR_HUMAN;tr|B4DJS2|B4DJS2_HUMAN","sp|Q9BY49|PECR_HUMAN;tr|B4DJS2|B4DJS2_HUMAN",4055,"Q9BY49","PECR_HUMAN","Peroxisomal trans-2-enoyl-CoA reductase","ERP","PECR"]
["15.5534","18.673",1,"18.9266",{"$nulls":3},"histone H3 acetylation;histone H4 acetylation;positive regulation of interleukin-1 beta secretion;positive regulation of keratinocyte differentiation;positive regulation of retinoic acid receptor signaling pathway;positive regulation of transcription, DNA-templated;response to growth hormone;response to organophosphorus;response to retinoic acid","DNA binding;interleukin-1 binding;NACHT domain binding;zinc ion binding","cytoplasm;cytosol;plasma membrane;PML body",{"$nulls":3},5,5,5,16,16,16,"63.954",0,"13.134",54346000,9,"0.288817",1,"7.14991","0.785878","sp|O95361|TRI16_HUMAN;tr|H0Y626|H0Y626_HUMAN;tr|K7ENN8|K7ENN8_HUMAN;tr|B3KP96|B3KP96_HUMAN;tr|J3QKY5|J3QKY5_HUMAN;tr|K7EL43|K7EL43_HUMAN;tr|I3L3K9|I3L3K9_HUMAN;tr|I3L2F3|I3L2F3_HUMAN;sp|Q309B1|TR16L_HUMAN","sp|O95361|TRI16_HUMAN;tr|H0Y626|H0Y626_HUMAN;tr|K7ENN8|K7ENN8_HUMAN;tr|B3KP96|B3KP96_HUMAN",720,"O95361","TRI16_HUMAN","Tripartite motif-containing protein 16",null,"TRIM16"]
["15.3199","15.9998","16.0201",1,{"$nulls":3},"DNA double-strand break processing;double-strand break repair;double-strand break repair via homologous recombination;nucleic acid phosphodiester bond hydrolysis","3'-5' exonuclease activity;exodeoxyribonuclease I activity;nucleic acid binding;single-stranded DNA 3'-5' exodeoxyribonuclease activity","cytoplasm;nucleus",{"$nulls":3},4,4,4,"8.9","8.9","8.9","70.352",0,"12.532",107950000,22,"0.354622",1,"7.14979","0.951053","sp|Q9NVH0|EXD2_HUMAN;tr|C9JLF4|C9JLF4_HUMAN","sp|Q9NVH0|EXD2_HUMAN",4488,"Q9NVH0","EXD2_HUMAN","Exonuclease 3'-5' domain-containing protein 2 {ECO:0000312|HGNC:HGNC:20217}",null,"EXD2"]
["15.9795","18.4084",1,"19.0899",{"$nulls":4},"SUMO transferase activity;zinc ion binding",{"$nulls":4},1,1,1,"5.3","5.3","5.3","31.239","0.00067129","4.1699",74827000,3,"0.28781",1,"7.149","0.783355","tr|B4DGW0|B4DGW0_HUMAN;tr|A0A087WUY7|A0A087WUY7_HUMAN;sp|O75928|PIAS2_HUMAN;sp|O75925|PIAS1_HUMAN","tr|B4DGW0|B4DGW0_HUMAN;tr|A0A087WUY7|A0A087WUY7_HUMAN;sp|O75928|PIAS2_HUMAN;sp|O75925|PIAS1_HUMAN",628,"B4DGW0","B4DGW0_HUMAN",null,null,"PIAS2"]
["17.9846","15.4829","18.1964",1,{"$nulls":3},"miRNA mediated inhibition of translation","nucleic acid binding",{"$nulls":4},8,8,8,"10.8","10.8","10.8","148.57",0,"62.374",101820000,17,"0.302923",1,"7.13554","0.821241","tr|H0Y720|H0Y720_HUMAN;sp|Q9UPQ9|TNR6B_HUMAN","tr|H0Y720|H0Y720_HUMAN;sp|Q9UPQ9|TNR6B_HUMAN",4869,"H0Y720","H0Y720_HUMAN",null,null,"TNRC6B"]
["15.6098","13.9282","14.2803",1,{"$nulls":3},"cellular response to glucose stimulus;chemical synaptic transmission;glutamate secretion;innervation;intracellular signal transduction;negative regulation of synaptic plasticity;neuromuscular junction development;neurotransmitter secretion;phagosome maturation;positive regulation of apoptotic process;positive regulation of defense response to bacterium;positive regulation of inhibitory postsynaptic potential;positive regulation of protein secretion;positive regulation of synaptic vesicle priming;presynaptic dense core vesicle exocytosis;regulation of short-term neuronal synaptic plasticity;synaptic transmission, glutamatergic;synaptic vesicle docking;synaptic vesicle exocytosis;synaptic vesicle priming","calcium ion binding;calmodulin binding;diacylglycerol binding;GTP-dependent protein binding;phospholipid binding;Rab GTPase binding","calyx of Held;cell junction;cytosol;early phagosome;Golgi apparatus;membrane;neuromuscular junction;plasma membrane;presynaptic active zone;ribbon synapse;terminal bouton","Synaptic vesicle cycle",null,null,2,2,2,"2.2","2.2","2.2","180.68","0.00067966","4.3463",24083000,3,"0.399682",1,"7.12886","1.06509","sp|O14795|UN13B_HUMAN;tr|B1AM27|B1AM27_HUMAN","sp|O14795|UN13B_HUMAN;tr|B1AM27|B1AM27_HUMAN",288,"O14795","UN13B_HUMAN","Protein unc-13 homolog B",null,"UNC13B"]
["16.4131","16.561","17.7243",1,{"$nulls":3},"cellular response to dexamethasone stimulus;DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;negative regulation by host of viral transcription;negative regulation of cell cycle arrest;negative regulation of cell proliferation;negative regulation of cyclin-dependent protein serine/threonine kinase activity;negative regulation of DNA binding;negative regulation of transcription, DNA-templated;positive regulation by host of viral transcription;positive regulation of apoptotic process;positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;positive regulation of transcription, DNA-templated;protein complex assembly;regulation of mitotic cell cycle phase transition","DNA binding;E-box binding;histone deacetylase binding;protein homodimerization activity;sequence-specific DNA binding;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","mitochondrion;nucleus;transcriptional repressor complex","Proteoglycans in cancer",null,null,1,1,1,"4.7","4.7","4.7","38.725","0.001301","3.7271",6808500,2,"0.315193",1,"7.12489","0.852005","sp|Q01664|TFAP4_HUMAN","sp|Q01664|TFAP4_HUMAN",2052,"Q01664","TFAP4_HUMAN","Transcription factor AP-4",null,"TFAP4"]
["17.7887","15.4953","18.0666",1,{"$nulls":3},"biomineral tissue development;mRNA splicing, via spliceosome;negative regulation of DNA ligase activity;negative regulation of double-strand break repair via nonhomologous end joining;negative regulation of protein binding;negative regulation of protein complex assembly;protection from non-homologous end joining at telomere;regulation of transcription, DNA-templated;RNA processing;spliceosomal complex disassembly","DNA binding","catalytic step 2 spliceosome;cytoplasm;nuclear chromosome, telomeric region;nuclear speck;nucleolus;nucleoplasm;proteinaceous extracellular matrix;spliceosomal complex;U2-type post-mRNA release spliceosomal complex",{"$nulls":3},8,8,8,"13.3","13.3","13.3","96.819",0,"20.956",217210000,32,"0.304675",1,"7.10871","0.825634","sp|Q9UBB9|TFP11_HUMAN;tr|H0Y4U8|H0Y4U8_HUMAN","sp|Q9UBB9|TFP11_HUMAN",4655,"Q9UBB9","TFP11_HUMAN","Tuftelin-interacting protein 11",null,"TFIP11"]
["16.4619","17.1056",1,"18.387",{"$nulls":3},"negative regulation of insulin receptor signaling pathway;protein dephosphorylation","transmembrane receptor protein tyrosine phosphatase activity","cytoplasm;integral component of membrane;nucleus;plasma membrane",{"$nulls":3},2,2,2,"3.3","3.3","3.3","80.641","0.00025355","6.6484",35007000,3,"0.300443",1,"7.09027","0.815025","sp|P23469|PTPRE_HUMAN","sp|P23469|PTPRE_HUMAN",1202,"P23469","PTPRE_HUMAN","Receptor-type tyrosine-protein phosphatase epsilon",{"$f":"-PTP-epsilon,rotein-tyrosine phosphatase epsilon","v":{"$error":"#NAME?"}},"PTPRE"]
["17.2816","15.3461","17.4742",1,{"$nulls":3},"mechanosensory behavior;multicellular organism development;spermatid development","DNA binding;double-stranded RNA binding;RNA binding;single-stranded RNA binding","cytoplasm;microtubule cytoskeleton;nucleus",{"$nulls":3},9,5,5,"15.6","10.6","10.6","73.652","0.00025069","6.4208",44984000,5,"0.315695",1,"7.07674","0.853262","sp|Q96SI9|STRBP_HUMAN;tr|H0YC91|H0YC91_HUMAN","sp|Q96SI9|STRBP_HUMAN",3820,"Q96SI9","STRBP_HUMAN","Spermatid perinuclear RNA-binding protein",null,"STRBP"]
["13.5272","14.6651","13.0469",1,{"$nulls":4},"carbohydrate binding;protein kinase A binding","protein complex",{"$nulls":3},2,2,2,"1.3","1.3","1.3","330.63","0.00023975","5.4782",11294000,3,"0.440235",1,"7.07272","1.16899","sp|Q68DQ2|CRBG3_HUMAN","sp|Q68DQ2|CRBG3_HUMAN",2796,"Q68DQ2","CRBG3_HUMAN","Very large A-kinase anchor protein","lAKAP","CRYBG3"]
["19.5301","15.26","19.6543",1,{"$nulls":3},"activation of JUN kinase activity;apoptotic process;Fc-epsilon receptor signaling pathway;JNK cascade;positive regulation of telomerase activity;positive regulation of telomere capping;positive regulation of telomere maintenance via telomerase;proteolysis in other organism;regulation of apoptotic process;regulation of mitotic cell cycle;response to heat;response to osmotic stress;response to tumor necrosis factor;response to UV;signal transduction;stress-activated MAPK cascade","ATP binding;enzyme binding;magnesium ion binding;MAP kinase kinase activity;protein kinase binding;protein phosphatase binding;protein serine/threonine kinase activity;protein tyrosine kinase activity","cytoplasm;cytosol;nucleus","Epstein-Barr virus infection;ErbB signaling pathway;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;GnRH signaling pathway;Hepatitis B;Human immunodeficiency virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;MAPK signaling pathway;Neurotrophin signaling pathway;Osteoclast differentiation;Protein processing in endoplasmic reticulum;Relaxin signaling pathway;T cell receptor signaling pathway;Tight junction;TNF signaling pathway;Toll-like receptor signaling pathway;Yersinia infection",null,null,8,8,8,27,27,27,"47.484",0,"27.174",454610000,38,"0.27",1,"7.06787","0.738668","sp|O14733|MP2K7_HUMAN","sp|O14733|MP2K7_HUMAN",276,"O14733","MP2K7_HUMAN","Dual specificity mitogen-activated protein kinase kinase 7","AP kinase kinase 7;APKK 7","MAP2K7"]
["16.7857","15.3941","17.2206",1,{"$nulls":3},"RNA processing","ATP binding;ATP-dependent RNA helicase activity;cadherin binding;ribosomal small subunit binding;RNA binding;translation initiation factor activity","eukaryotic 43S preinitiation complex;mitochondrion",{"$nulls":3},5,5,5,"5.6","5.6","5.6","155.23",0,"13.201",103560000,13,"0.317359",1,"6.97961","0.857435","sp|Q7Z478|DHX29_HUMAN;tr|A0A087WYN9|A0A087WYN9_HUMAN","sp|Q7Z478|DHX29_HUMAN;tr|A0A087WYN9|A0A087WYN9_HUMAN",3000,"Q7Z478","DHX29_HUMAN","ATP-dependent RNA helicase DHX29 {ECO:0000255|HAMAP-Rule:MF_03068}",null,"DHX29"]
["17.2597","15.976","18.3492",1,{"$nulls":3},"snRNA transcription from RNA polymerase II promoter",null,"nucleoplasm",{"$nulls":3},4,4,4,"13.1","13.1","13.1","57.47","0.0002574","7.0041",63800000,5,"0.293743",1,"6.94324","0.79823","sp|Q96SY0|VWA9_HUMAN;tr|B4DJL6|B4DJL6_HUMAN;tr|H3BRY6|H3BRY6_HUMAN;tr|B4DVT3|B4DVT3_HUMAN;tr|H3BP17|H3BP17_HUMAN;tr|H3BMK7|H3BMK7_HUMAN","sp|Q96SY0|VWA9_HUMAN;tr|B4DJL6|B4DJL6_HUMAN;tr|H3BRY6|H3BRY6_HUMAN;tr|B4DVT3|B4DVT3_HUMAN",3827,"Q96SY0","INT14_HUMAN","Integrator complex subunit 14 {ECO:0000312|HGNC:HGNC:25372}",null,"INTS14"]
["17.3692","14.9918","17.602",1,{"$nulls":3},"cell cycle;cell division;maintenance of centrosome location;posttranscriptional regulation of gene expression;production of miRNAs involved in gene silencing by miRNA","methyltransferase activity;miRNA binding;RNA binding","condensed chromosome kinetochore;cytoplasm;kinetochore;mitotic spindle;spindle pole centrosome",{"$nulls":3},7,7,7,"22.1","22.1","22.1","42.008",0,"69.656",412780000,36,"0.30258",1,"6.87948","0.820382","sp|Q5T280|CI114_HUMAN;tr|A0A087WYA7|A0A087WYA7_HUMAN;tr|R4GNG4|R4GNG4_HUMAN","sp|Q5T280|CI114_HUMAN",2723,"Q5T280","CI114_HUMAN","Putative methyltransferase C9orf114 {ECO:0000305}",null,"SPOUT1"]
["17.3042","16.1175","18.6745",1,{"$nulls":5},"nucleolus",{"$nulls":3},6,6,6,"21.4","21.4","21.4","48.208",0,"19.099",197580000,17,"0.284898",1,"6.8736","0.776052","tr|J3QSV6|J3QSV6_HUMAN;sp|O76021|RL1D1_HUMAN;tr|I3L3U9|I3L3U9_HUMAN;tr|I3L234|I3L234_HUMAN;tr|I3L3C4|I3L3C4_HUMAN;tr|J3KPU7|J3KPU7_HUMAN;tr|I3L2F2|I3L2F2_HUMAN;tr|I3L4T8|I3L4T8_HUMAN;tr|I3L1Y4|I3L1Y4_HUMAN","tr|J3QSV6|J3QSV6_HUMAN;sp|O76021|RL1D1_HUMAN;tr|I3L3U9|I3L3U9_HUMAN",639,"J3QSV6","J3QSV6_HUMAN",null,null,"RSL1D1"]
["17.387","14.8589","17.5947",1,{"$nulls":3},"anterograde axonal transport;mitochondrial calcium ion transmembrane transport;mitochondrial outer membrane permeabilization involved in programmed cell death;nervous system development;proteolysis;regulation of mitochondrial membrane permeability","ATP binding;metalloendopeptidase activity;peptidase activity;unfolded protein binding;zinc ion binding","axon cytoplasm;m-AAA complex;mitochondrial inner membrane;mitochondrial permeability transition pore complex;mitochondrion",{"$nulls":3},7,7,7,"13.7","13.7","13.7","88.234",0,"20.086",131360000,22,"0.299731",1,"6.8256","0.813241","sp|Q9UQ90|SPG7_HUMAN;tr|H3BTR8|H3BTR8_HUMAN;tr|J3KRF6|J3KRF6_HUMAN;tr|H3BTY6|H3BTY6_HUMAN","sp|Q9UQ90|SPG7_HUMAN",4881,"Q9UQ90","SPG7_HUMAN","Paraplegin {ECO:0000250|UniProtKB:Q3ULF4}",null,"SPG7"]
["16.6989","14.6454","16.7156",1,{"$nulls":4},"metal ion binding;RNA binding",{"$nulls":4},17,17,17,"15.6","15.6","15.6","164.2",0,"66.118",435390000,71,"0.318342",1,"6.81436","0.859901","sp|Q9UKJ3|GPTC8_HUMAN;tr|K7EKU0|K7EKU0_HUMAN","sp|Q9UKJ3|GPTC8_HUMAN",4784,"Q9UKJ3","GPTC8_HUMAN","G patch domain-containing protein 8",null,"GPATCH8"]
["16.3271","15.0682","16.8864",1,{"$nulls":3},"in utero embryonic development;liver development;lung alveolus development;mannose metabolic process;mitochondrion organization;N-glycan processing;positive regulation of neurogenesis;protein deglycosylation;protein glycosylation;respiratory gaseous exchange;retina morphogenesis in camera-type eye;vacuole organization","alpha-mannosidase activity;carbohydrate binding;hydrolase activity, hydrolyzing N-glycosyl compounds;mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity;metal ion binding","cis-Golgi network;extracellular exosome;Golgi medial cisterna;Golgi membrane;integral component of membrane;membrane","Metabolic pathways;N-Glycan biosynthesis",null,null,3,3,3,"2.7","2.7","2.7","131.14","0.0019173","3.4695",13741000,2,"0.31347",1,"6.75444","0.847683","sp|Q16706|MA2A1_HUMAN","sp|Q16706|MA2A1_HUMAN",2565,"Q16706","MA2A1_HUMAN","Alpha-mannosidase 2",null,"MAN2A1"]
["16.3501","15.5441","17.3857",1,{"$nulls":3},"anatomical structure morphogenesis;cell differentiation;muscle organ development;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;protein deubiquitination;transcription, DNA-templated","RNA polymerase II regulatory region sequence-specific DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"12.8","12.8","12.8","75.456","0.00067659","4.289",17921000,5,"0.30379",1,"6.75426","0.823416","sp|P85037|FOXK1_HUMAN;tr|U3KQ26|U3KQ26_HUMAN","sp|P85037|FOXK1_HUMAN",2015,"P85037","FOXK1_HUMAN","Forkhead box protein K1",null,"FOXK1"]
["13.4947","15.0285",1,"14.017",{"$nulls":3},"endocytosis;regulation of Rho protein signal transduction","calcium ion binding;Rho guanyl-nucleotide exchange factor activity",{"$nulls":4},4,4,4,"2.7","2.7","2.7","191.6","0.00025523","6.8204",23812000,1,"0.386049",1,"6.75313","1.03046","tr|A0A087WVF7|A0A087WVF7_HUMAN;sp|Q9NZM3|ITSN2_HUMAN;tr|E7EPJ2|E7EPJ2_HUMAN","tr|A0A087WVF7|A0A087WVF7_HUMAN;sp|Q9NZM3|ITSN2_HUMAN;tr|E7EPJ2|E7EPJ2_HUMAN",4598,"A0A087WVF7","A0A087WVF7_HUMAN",null,null,"ITSN2"]
["17.0621","14.3533","16.9336",1,{"$nulls":3},"actin filament organization",{"$nulls":5},3,3,3,"6.8","6.8","6.8","70.174","0.0013126","3.853",20818000,1,"0.308073",1,"6.74088","0.834151","tr|H7BXR3|H7BXR3_HUMAN;sp|O94875|SRBS2_HUMAN;tr|H7C1R7|H7C1R7_HUMAN;tr|H7BZK1|H7BZK1_HUMAN;tr|C9J3W4|C9J3W4_HUMAN;tr|C9JL62|C9JL62_HUMAN;tr|C9IZ89|C9IZ89_HUMAN;tr|H7BZX1|H7BZX1_HUMAN","tr|H7BXR3|H7BXR3_HUMAN;sp|O94875|SRBS2_HUMAN;tr|H7C1R7|H7C1R7_HUMAN;tr|H7BZK1|H7BZK1_HUMAN",662,"H7BXR3","H7BXR3_HUMAN",null,null,"SORBS2"]
["15.1862","15.8635","16.6424",1,{"$nulls":9},2,2,2,"3.4","3.4","3.4","74.789","0.0036923","2.9615",12551000,1,"0.316909",1,"6.70363","0.856306","tr|H0Y6I6|H0Y6I6_HUMAN;sp|Q96ME1|FXL18_HUMAN","tr|H0Y6I6|H0Y6I6_HUMAN;sp|Q96ME1|FXL18_HUMAN",3770,"H0Y6I6","H0Y6I6_HUMAN",null,null,"FBXL18"]
["16.9194","16.2355","18.7505",1,{"$nulls":3},"cellular protein metabolic process;post-translational protein modification;regulation of protein targeting;response to cisplatin","calcium ion binding;DNA binding;G-protein alpha-subunit binding","cis-Golgi network;early endosome;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular space;extrinsic component of Golgi membrane;Golgi cisterna membrane;Golgi-associated vesicle;lumenal side of Golgi membrane;membrane;nucleus;rough endoplasmic reticulum;trans-Golgi network",{"$nulls":3},4,4,4,"9.1","9.1","9.1","53.879","0.0002426","5.719",48482000,5,"0.276346",1,"6.70221","0.754597","sp|Q02818|NUCB1_HUMAN;tr|C9JKZ2|C9JKZ2_HUMAN;tr|H7BZI1|H7BZI1_HUMAN;tr|C9JBD3|C9JBD3_HUMAN;tr|C9J3C1|C9J3C1_HUMAN","sp|Q02818|NUCB1_HUMAN;tr|C9JKZ2|C9JKZ2_HUMAN;tr|H7BZI1|H7BZI1_HUMAN",2073,"Q02818","NUCB1_HUMAN","Nucleobindin-1",null,"NUCB1"]
["15.6169","15.7731",1,"16.9858",{"$nulls":3},"cell cycle;cell division;cellular response to DNA damage stimulus;histone deubiquitination;histone H2A K63-linked deubiquitination;mitotic cell cycle;monoubiquitinated histone H2A deubiquitination;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of translational elongation;protein deubiquitination;protein homotetramerization;regulation of cell cycle;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;ubiquitin-dependent protein catabolic process","cysteine-type endopeptidase activity;histone binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;transcription coactivator activity;ubiquitin binding;zinc ion binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"7.4","7.4","7.4","93.569",0,"22.497",120770000,13,"0.309791",1,"6.70205","0.83846","sp|Q9Y5T5|UBP16_HUMAN","sp|Q9Y5T5|UBP16_HUMAN",5056,"Q9Y5T5","UBP16_HUMAN","Ubiquitin carboxyl-terminal hydrolase 16 {ECO:0000255|HAMAP-Rule:MF_03062}",null,"USP16"]
["15.4718","16.5848",1,"17.7222",{"$nulls":4},"identical protein binding;protein C-terminus binding","Cajal body;fibrillar center;membrane;nuclear body;nucleolus;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"8.2","8.2","8.2","62.608",0,"8.0385",45282000,10,"0.292713",1,"6.66721","0.795647","sp|P38432|COIL_HUMAN","sp|P38432|COIL_HUMAN",1425,"P38432","COIL_HUMAN","Coilin",null,"COIL"]
["14.788","15.7065","16.2673",1,{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","RNA binding","nucleolus;nucleus",{"$nulls":3},9,9,9,"17.6","17.6","17.6","84.468",0,"29.908",214040000,31,"0.3203",1,"6.61361","0.864813","sp|Q5QJE6|TDIF2_HUMAN;tr|J3KP30|J3KP30_HUMAN;tr|E9PRB3|E9PRB3_HUMAN","sp|Q5QJE6|TDIF2_HUMAN;tr|J3KP30|J3KP30_HUMAN",2708,"Q5QJE6","TDIF2_HUMAN","Deoxynucleotidyltransferase terminal-interacting protein 2",null,"DNTTIP2"]
["15.7993","15.0609",1,"16.651",{"$nulls":3},"7-methylguanosine mRNA capping;apoptotic process;DNA repair;DNA topological change;embryonic organ development;global genome nucleotide-excision repair;hair cell differentiation;nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;positive regulation of apoptotic process;positive regulation of transcription from RNA polymerase II promoter;protein localization;protein phosphorylation;regulation of mitotic cell cycle phase transition;response to hypoxia;response to oxidative stress;response to UV;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair;UV protection;viral process","3'-5' DNA helicase activity;ATP binding;ATPase activity;ATP-dependent DNA helicase activity;damaged DNA binding;DNA binding;helicase activity;protein C-terminus binding;protein N-terminus binding;transcription factor binding","core TFIIH complex;holo TFIIH complex;nucleoplasm;nucleus;transcription factor TFIID complex","Basal transcription factors;Nucleotide excision repair",null,null,16,16,16,"27.7","27.7","27.7","89.277",0,"57.216",623880000,77,"0.311619",1,"6.60457","0.843042","sp|P19447|ERCC3_HUMAN;tr|H7C309|H7C309_HUMAN","sp|P19447|ERCC3_HUMAN",1136,"P19447","ERCC3_HUMAN","General transcription and DNA repair factor IIH helicase subunit XPB","FIIH subunit XPB","ERCC3"]
["14.1573","15.1364","15.1739",1,{"$nulls":3},"actin cytoskeleton reorganization;activation of JNKK activity;cytoskeleton organization;intracellular signal transduction;microvillus assembly;positive regulation of protein phosphorylation;protein autophosphorylation;protein localization to plasma membrane;protein phosphorylation;regulation of apoptotic process;regulation of dendrite morphogenesis;regulation of mitotic cell cycle;Wnt signaling pathway","ATP binding;MAP kinase kinase kinase kinase activity;protein kinase activity;protein serine/threonine kinase activity","apical plasma membrane;cytoplasm;cytoskeleton;cytosol;extracellular exosome;nucleoplasm;nucleus;recycling endosome",{"$nulls":3},18,10,10,"17.2","11.2","11.2","154.94",0,"29.465",221240000,38,"0.343646",1,"6.55991","0.923434","sp|Q9UKE5|TNIK_HUMAN","sp|Q9UKE5|TNIK_HUMAN",4780,"Q9UKE5","TNIK_HUMAN","TRAF2 and NCK-interacting protein kinase",null,"TNIK"]
["14.8832","14.8461","15.6746",1,{"$nulls":3},"box H/ACA snoRNP assembly;negative regulation of rRNA processing;positive regulation of apoptotic process;positive regulation of telomerase RNA localization to Cajal body;ribonucleoprotein complex assembly","unfolded protein binding","cytoplasm;cytosol;nucleoplasm",{"$nulls":3},2,2,2,"4.2","4.2","4.2","65.124","0.0013118","3.8458",6491000,1,"0.330184",1,"6.52738","0.889615","sp|Q6PI26|SHQ1_HUMAN","sp|Q6PI26|SHQ1_HUMAN",2878,"Q6PI26","SHQ1_HUMAN","Protein SHQ1 homolog",null,"SHQ1"]
["15.844","14.1681","15.9718",1,{"$nulls":3},"early endosome to late endosome transport;endocytic recycling;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;protein autophosphorylation;protein phosphorylation;receptor recycling;transferrin transport","ATP binding;myosin VI binding;protein phosphatase inhibitor activity;protein serine/threonine kinase activity","cytosol;early endosome;Golgi apparatus;growth cone;integral component of membrane;neuronal cell body;perinuclear region of cytoplasm;recycling endosome",{"$nulls":3},2,2,2,"2.1","2.1","2.1","164.9","0.0037368","3.1405",15435000,5,"0.320611",1,"6.52019","0.865592","sp|Q8IWU2|LMTK2_HUMAN","sp|Q8IWU2|LMTK2_HUMAN",3133,"Q8IWU2","LMTK2_HUMAN","Serine/threonine-protein kinase LMTK2",null,"LMTK2"]
["16.7016","14.3747","17.0428",1,{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;bile acid biosynthetic process;cholesterol metabolic process;vesicle-mediated transport","cholesterol binding;phospholipid binding;sterol transporter activity","cytosol;extracellular exosome;intracellular;late endosome",{"$nulls":3},3,3,3,"3.3","3.3","3.3","108.47","0.0048761","2.8464",32935000,3,"0.296047",1,"6.51673","0.804005","sp|Q9BXW6|OSBL1_HUMAN;tr|J3QSB8|J3QSB8_HUMAN","sp|Q9BXW6|OSBL1_HUMAN",4048,"Q9BXW6","OSBL1_HUMAN","Oxysterol-binding protein-related protein 1","RP-1;SBP-related protein 1","OSBPL1A"]
["13.8423","13.0149",1,"12.9682",{"$nulls":3},"axon development;microtubule cytoskeleton organization;regulation of dendrite development;regulation of Golgi organization;regulation of microtubule polymerization;regulation of organelle organization","calmodulin binding;microtubule minus-end binding;spectrin binding","cytosol;Golgi apparatus;microtubule end",{"$nulls":3},1,1,1,"0.9","0.9","0.9","168.09","0.0037313","3.1187",16112000,5,"0.403322",1,"6.44446","1.07436","sp|Q08AD1|CAMP2_HUMAN","sp|Q08AD1|CAMP2_HUMAN",2137,"Q08AD1","CAMP2_HUMAN","Calmodulin-regulated spectrin-associated protein 2 {ECO:0000305}",null,"CAMSAP2"]
["15.0269","14.3149","15.5171",1,{"$nulls":3},"cargo loading into vesicle;cytokinesis;cytoskeleton-dependent intracellular transport;endosome to lysosome transport;Golgi to plasma membrane protein transport;intracellular protein transport;melanosome organization;microtubule-based movement;plus-end-directed vesicle transport along microtubule","ATP binding;ATPase activity;microtubule binding;microtubule motor activity","centrosome;endosome membrane;kinesin complex;microtubule;midbody;trans-Golgi network membrane",{"$nulls":3},4,3,3,"2.8",2,2,"202.31","0.0006829","4.4053",12668000,4,"0.327296",1,"6.41236","0.882364","sp|Q9H1H9|KI13A_HUMAN;tr|H0Y9Z7|H0Y9Z7_HUMAN;tr|H0Y307|H0Y307_HUMAN","sp|Q9H1H9|KI13A_HUMAN;tr|H0Y9Z7|H0Y9Z7_HUMAN;tr|H0Y307|H0Y307_HUMAN",4156,"Q9H1H9","KI13A_HUMAN","Kinesin-like protein KIF13A",null,"KIF13A"]
["13.2513","15.896",1,"15.4611",{"$nulls":3},"actin cytoskeleton reorganization;activation of protein kinase B activity;embryo development;establishment of cell polarity;establishment or maintenance of actin cytoskeleton polarity;peptidyl-serine phosphorylation;positive regulation of actin filament polymerization;positive regulation of endothelial cell proliferation;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of protein kinase B signaling;positive regulation of TOR signaling;regulation of actin cytoskeleton organization;regulation of establishment of cell polarity;regulation of gene expression;regulation of GTPase activity;regulation of inflammatory response;regulation of peptidyl-serine phosphorylation;regulation of phosphorylation;regulation of protein kinase B signaling;TOR signaling","enzyme activator activity;protein kinase binding;ribosome binding","cytosol;TORC2 complex","mTOR signaling pathway",null,null,11,11,11,"8.4","8.4","8.4","192.22",0,"19.668",156670000,26,"0.319561",1,"6.34314","0.862957","sp|Q6R327|RICTR_HUMAN","sp|Q6R327|RICTR_HUMAN",2892,"Q6R327","RICTR_HUMAN","Rapamycin-insensitive companion of mTOR",null,"RICTOR"]
["14.0292","15.3062","15.6567",1,{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA processing","RNA binding","nuclear membrane;nucleolus;nucleoplasm;nucleus;Pwp2p-containing subcomplex of 90S preribosome;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,9,9,9,"24.3","24.3","24.3","62.003",0,"26.871",191880000,32,"0.31909",1,"6.33934","0.861776","sp|Q9Y5J1|UTP18_HUMAN;tr|J3KSR7|J3KSR7_HUMAN;tr|J3QRG0|J3QRG0_HUMAN;tr|J3QR85|J3QR85_HUMAN;tr|J3QLD6|J3QLD6_HUMAN","sp|Q9Y5J1|UTP18_HUMAN",5039,"Q9Y5J1","UTP18_HUMAN","U3 small nucleolar RNA-associated protein 18 homolog",null,"UTP18"]
["13.9028","13.8391","14.2371",1,{"$nulls":3},"negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA catabolic process;RNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;membrane",{"$nulls":3},8,8,8,"11.5","11.5","11.5","128.12",0,"37.784",92822000,20,"0.352087",1,"6.2524","0.94467","sp|Q14147|DHX34_HUMAN;tr|H7C504|H7C504_HUMAN","sp|Q14147|DHX34_HUMAN",2334,"Q14147","DHX34_HUMAN","Probable ATP-dependent RNA helicase DHX34",null,"DHX34"]
["15.1691","15.7237","17.3964",1,{"$nulls":3},"actin cytoskeleton organization;cell migration;cytoskeleton organization;epithelial cell morphogenesis;keratinocyte development","actin binding;muscle alpha-actinin binding","actin cytoskeleton;actin filament;axon;cytosol;focal adhesion;growth cone;lamellipodium;nucleus;plasma membrane;podosome;ruffle;Z disc",{"$nulls":3},2,2,2,"1.7","1.7","1.7","150.56","0.00026226","7.3666",55198000,8,"0.279181",1,"6.24824","0.761712","sp|Q8WX93|PALLD_HUMAN;tr|H0YA05|H0YA05_HUMAN","sp|Q8WX93|PALLD_HUMAN;tr|H0YA05|H0YA05_HUMAN",3461,"Q8WX93","PALLD_HUMAN","Palladin",null,"PALLD"]
["17.8198","14.1217","18.5147",1,{"$nulls":3},"maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA methylation","RNA binding;rRNA (guanine) methyltransferase activity;rRNA (uridine-2'-O-)-methyltransferase activity","nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},19,19,19,"29.6","29.6","29.6","96.557",0,"67.964",497180000,75,"0.252315",1,"6.21341","0.694201","sp|Q8IY81|SPB1_HUMAN;tr|J3QSE2|J3QSE2_HUMAN;tr|J3KS36|J3KS36_HUMAN","sp|Q8IY81|SPB1_HUMAN",3159,"Q8IY81","SPB1_HUMAN","pre-rRNA processing protein FTSJ3 {ECO:0000255|HAMAP-Rule:MF_03163}",null,"FTSJ3"]
["14.8449","13.8009","15.3454",1,{"$nulls":3},"epithelial cell-cell adhesion;zonula adherens maintenance","delta-catenin binding","cell junction;centrosome;cytosol;extracellular exosome;nucleus;zonula adherens",{"$nulls":3},5,5,5,"6.5","6.5","6.5","127.13",0,"12.068",59762000,8,"0.316461",1,"6.15019","0.855185","sp|Q6IQ23|PKHA7_HUMAN;tr|E9PKC0|E9PKC0_HUMAN;tr|H0YDE2|H0YDE2_HUMAN;tr|E9PIK1|E9PIK1_HUMAN;tr|E9PL74|E9PL74_HUMAN","sp|Q6IQ23|PKHA7_HUMAN;tr|E9PKC0|E9PKC0_HUMAN;tr|H0YDE2|H0YDE2_HUMAN",2824,"Q6IQ23","PKHA7_HUMAN","Pleckstrin homology domain-containing family A member 7","H domain-containing family A member 7","PLEKHA7"]
["13.6775","16.6528",1,"17.1138",{"$nulls":3},"hair follicle maturation;neurogenesis;ribosomal small subunit biogenesis","RNA binding","nucleolus;nucleus",{"$nulls":3},15,15,15,"20.7","20.7","20.7","96.256",0,"75.388",482830000,48,"0.272737",1,"6.10827","0.745539","sp|Q5C9Z4|NOM1_HUMAN","sp|Q5C9Z4|NOM1_HUMAN",2680,"Q5C9Z4","NOM1_HUMAN","Nucleolar MIF4G domain-containing protein 1",null,"NOM1"]
["15.2238","17.1201",1,"19.1369",{"$nulls":3},"response to X-ray",null,"endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane",{"$nulls":3},3,3,3,"8.6","8.6","8.6","39.309","0.00024606","5.991",73665000,6,"0.242475",1,"6.10351","0.669401","sp|Q70UQ0|IKIP_HUMAN","sp|Q70UQ0|IKIP_HUMAN",2945,"Q70UQ0","IKIP_HUMAN","Inhibitor of nuclear factor kappa-B kinase-interacting protein"," kappa-B kinase-interacting protein;KBKB-interacting protein;KK-interacting protein","IKBIP"]
["14.354","13.0357","14.2754",1,{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},3,3,3,"5.8","5.8","5.8","102.13","0.00024516","5.8761",28668000,5,"0.337536",1,"6.05719","0.908077","tr|A0A087WWP4|A0A087WWP4_HUMAN;sp|Q96T37|RBM15_HUMAN","tr|A0A087WWP4|A0A087WWP4_HUMAN;sp|Q96T37|RBM15_HUMAN",3832,"A0A087WWP4","A0A087WWP4_HUMAN",null,null,"RBM15"]
["12.9984","13.6664",1,"13.6689",{"$nulls":3},"inactivation of MAPK activity;regulation of G-protein coupled receptor protein signaling pathway","GTPase activator activity","cytoplasm;cytosol;nucleoplasm;plasma membrane","Axon guidance",null,null,8,8,8,11,11,11,"132.33",0,"16.171",179730000,30,"0.352443",1,"5.99797","0.945568","sp|P49796|RGS3_HUMAN;tr|H7C539|H7C539_HUMAN;tr|Q5VXC0|Q5VXC0_HUMAN;tr|C9J582|C9J582_HUMAN;tr|C9J6G2|C9J6G2_HUMAN","sp|P49796|RGS3_HUMAN;tr|H7C539|H7C539_HUMAN",1604,"P49796","RGS3_HUMAN","Regulator of G-protein signaling 3","GP3;GS3","RGS3"]
["12.7322","12.0491","12.1526",1,{"$nulls":3},"microtubule anchoring","microtubule binding","cell projection;centriole;centrosome;membrane;nucleus;spindle",{"$nulls":3},13,13,13,"6.4","6.4","6.4","350.93",0,"33.788",223080000,39,"0.390098",1,"5.81433","1.04073","sp|Q5VT06|CE350_HUMAN;tr|H0Y6Q4|H0Y6Q4_HUMAN;tr|H0Y7F7|H0Y7F7_HUMAN;tr|Q5T2X4|Q5T2X4_HUMAN","sp|Q5VT06|CE350_HUMAN",2753,"Q5VT06","CE350_HUMAN","Centrosome-associated protein 350 {ECO:0000305}","ep350","CEP350"]
["17.2536","11.5915","16.2519",1,{"$nulls":3},"activation of cysteine-type endopeptidase activity;activation of GTPase activity;intracellular protein transport;positive regulation of proteolysis;regulation of vesicle fusion;retrograde transport, endosome to Golgi","cadherin binding;GTPase activator activity;guanyl-nucleotide exchange factor activity;PDZ domain binding;Rab GTPase binding","cytosol;endomembrane system;extracellular exosome;intracellular;microvillus;plasma membrane",{"$nulls":3},7,7,7,"20.7","20.7","20.7","57.117",0,"32.667",320840000,32,"0.259626",1,"5.79661","0.712598","sp|Q9BXI6|TB10A_HUMAN;tr|B5MD46|B5MD46_HUMAN;tr|H0Y2U5|H0Y2U5_HUMAN;tr|H7C1Q1|H7C1Q1_HUMAN;tr|H7C471|H7C471_HUMAN;tr|H0Y5R9|H0Y5R9_HUMAN;tr|F8WCD1|F8WCD1_HUMAN;tr|F8WDN6|F8WDN6_HUMAN;tr|F8W9Y7|F8W9Y7_HUMAN","sp|Q9BXI6|TB10A_HUMAN;tr|B5MD46|B5MD46_HUMAN",4041,"Q9BXI6","TB10A_HUMAN","TBC1 domain family member 10A",null,"TBC1D10A"]
["15.5406","12.7739","15.9473",1,{"$nulls":5},"fibrillar center;mitochondrion",{"$nulls":3},4,4,4,"2.7","2.7","2.7","233.27","0.00046827","4.9452",61815000,7,"0.273632",1,"5.68361","0.747786","tr|Q5T3Q7|Q5T3Q7_HUMAN;sp|Q9H583|HEAT1_HUMAN","tr|Q5T3Q7|Q5T3Q7_HUMAN;sp|Q9H583|HEAT1_HUMAN",4220,"Q5T3Q7","Q5T3Q7_HUMAN",null,null,"HEATR1"]
["14.8809","12.7577","15.3248",1,{"$nulls":3},"negative regulation of TOR signaling;regulation of small GTPase mediated signal transduction","GTPase activator activity","cytosol;nucleus;TSC1-TSC2 complex",{"$nulls":3},4,4,4,"4.4","4.4","4.4","194.39","0.00026695","7.7413",60033000,18,"0.286981",1,"5.65692","0.781274","tr|H3BMQ0|H3BMQ0_HUMAN;sp|P49815|TSC2_HUMAN;tr|H3BQK4|H3BQK4_HUMAN","tr|H3BMQ0|H3BMQ0_HUMAN;sp|P49815|TSC2_HUMAN;tr|H3BQK4|H3BQK4_HUMAN",1605,"H3BMQ0","H3BMQ0_HUMAN",null,null,"TSC2"]
["14.6812","15.2393",1,"17.7029",{"$nulls":3},"protein localization to plasma membrane;protein targeting to Golgi;regulation of defense response to virus by virus","ion channel binding","COPI-coated vesicle;cytosol",{"$nulls":3},6,6,6,"11.7","11.7","11.7","104.9",0,"9.4925",64427000,11,"0.243198",1,"5.60882","0.671223","sp|Q6VY07|PACS1_HUMAN;tr|B4DF77|B4DF77_HUMAN;tr|E9PNZ9|E9PNZ9_HUMAN;tr|E9PSE1|E9PSE1_HUMAN;tr|E9PSG7|E9PSG7_HUMAN;tr|H0YCU5|H0YCU5_HUMAN;tr|E9PPK2|E9PPK2_HUMAN","sp|Q6VY07|PACS1_HUMAN;tr|B4DF77|B4DF77_HUMAN",2917,"Q6VY07","PACS1_HUMAN","Phosphofurin acidic cluster sorting protein 1","ACS-1","PACS1"]
["13.3621","14.2341",1,"15.5223",{"$nulls":3},"regulation of transcription, DNA-templated;RNA splicing;transcription, DNA-templated","double-stranded DNA binding;RNA binding;zinc ion binding","cytoplasm;intracellular membrane-bounded organelle;nuclear speck;nucleoplasm",{"$nulls":3},7,7,7,"5.8","5.8","5.8","220.62",0,"20.357",96456000,17,"0.278964",1,"5.53691","0.761166","sp|Q14966|ZN638_HUMAN;tr|A0A096LPH6|A0A096LPH6_HUMAN;tr|C9JWN0|C9JWN0_HUMAN","sp|Q14966|ZN638_HUMAN",2405,"Q14966","ZN638_HUMAN","Zinc finger protein 638",null,"ZNF638"]
["17.0136","13.9409","19.8501",1,{"$nulls":5},"nucleolus",{"$nulls":3},8,8,8,"35.2","35.2","35.2","27.091",0,"48.087",261730000,40,"0.187342",1,"5.05217","0.529054","tr|E7ENR5|E7ENR5_HUMAN;tr|H0Y714|H0Y714_HUMAN;sp|Q96G21|IMP4_HUMAN;tr|B9A008|B9A008_HUMAN;tr|B8ZZ47|B8ZZ47_HUMAN","tr|E7ENR5|E7ENR5_HUMAN;tr|H0Y714|H0Y714_HUMAN;sp|Q96G21|IMP4_HUMAN;tr|B9A008|B9A008_HUMAN;tr|B8ZZ47|B8ZZ47_HUMAN",3691,"E7ENR5","E7ENR5_HUMAN",null,null,"IMP4"]
["14.9621","9.00806","15.1164",1,{"$nulls":9},2,2,2,"0.6","0.6","0.6","336.22","0.0099655","2.1811",34293000,7,"0.180971",1,"3.92688","0.512624","sp|O15050|TRNK1_HUMAN","sp|O15050|TRNK1_HUMAN",318,"O15050","TRNK1_HUMAN","TPR and ankyrin repeat-containing protein 1",null,"TRANK1"]
["17.5804","22.3331","18.2204","15.331",{"$nulls":3},"chromatin remodeling;DNA-dependent DNA replication;regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding","ACF complex;CHRAC",{"$nulls":3},27,27,27,"22.4","22.4","22.4","178.7",0,"79.881",1162300000,117,"0.430472",1,"3.18108","1.14385","sp|Q9NRL2|BAZ1A_HUMAN;tr|A0A087WWN7|A0A087WWN7_HUMAN;tr|H0YJP5|H0YJP5_HUMAN","sp|Q9NRL2|BAZ1A_HUMAN",4422,"Q9NRL2","BAZ1A_HUMAN","Bromodomain adjacent to zinc finger domain protein 1A",null,"BAZ1A"]
["18.7024","19.7485","18.8595","14.4556",{"$nulls":3},"cell redox homeostasis;peptidyl-cysteine oxidation;platelet degranulation;protein folding;response to endoplasmic reticulum stress","protein disulfide isomerase activity;thiol oxidase activity","cell surface;endoplasmic reticulum membrane;integral component of membrane;plasma membrane;platelet alpha granule membrane",{"$nulls":3},6,6,6,"21.8","21.8","21.8","51.871",0,"36.292",111280000,15,"0.426891",1,"2.56795","1.13464","sp|Q96JJ7|TMX3_HUMAN;tr|B4DIE3|B4DIE3_HUMAN;tr|H3BPB3|H3BPB3_HUMAN","sp|Q96JJ7|TMX3_HUMAN",3745,"Q96JJ7","TMX3_HUMAN","Protein disulfide-isomerase TMX3",null,"TMX3"]
["21.1525","21.3956","21.2589","16.2216",{"$nulls":5},"endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},2,2,2,"12.6","12.6","12.6","17.221","0.00023518","5.0741",109560000,10,"0.375936",1,"2.53381","1.00485","tr|E5RGY0|E5RGY0_HUMAN;tr|B4E1G1|B4E1G1_HUMAN;sp|Q9BUN8|DERL1_HUMAN","tr|E5RGY0|E5RGY0_HUMAN;tr|B4E1G1|B4E1G1_HUMAN;sp|Q9BUN8|DERL1_HUMAN",3991,"E5RGY0","E5RGY0_HUMAN","Derlin {ECO:0000256|RuleBase:RU363059}",null,"DERL1"]
["21.0937","20.5408","21.006","15.5935",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cilium assembly;ER to Golgi vesicle-mediated transport;intraciliary transport involved in cilium assembly;macroautophagy;positive regulation of ATP-dependent microtubule motor activity, plus-end-directed;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;sister chromatid cohesion;transport along microtubule","cytoskeletal protein binding;dynein intermediate chain binding;dynein light intermediate chain binding;motor activity;protein heterodimerization activity;protein homodimerization activity;scaffold protein binding","centrosome;ciliary tip;cilium;cytoplasmic dynein complex;cytosol;membrane;microtubule;mitochondrion;myosin complex;myosin V complex;nucleus;plasma membrane","Vasopressin-regulated water reabsorption",null,null,3,3,2,"44.9","44.9","32.6","10.35",0,"9.885",96712000,9,"0.344439",1,"2.51746","0.925429","sp|Q96FJ2|DYL2_HUMAN","sp|Q96FJ2|DYL2_HUMAN",3684,"Q96FJ2","DYL2_HUMAN","Dynein light chain 2, cytoplasmic",null,"DYNLL2"]
["22.0058","20.5266","19.7088","17.9407",{"$nulls":3},"ribosomal large subunit biogenesis;rRNA processing","RNA binding","nuclear periphery;nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},9,9,9,"31.7","31.7","31.7","34.852",0,"23.317",565370000,41,"0.773836",1,"2.44146","2.11816","sp|Q99848|EBP2_HUMAN;tr|H7C2Q8|H7C2Q8_HUMAN","sp|Q99848|EBP2_HUMAN;tr|H7C2Q8|H7C2Q8_HUMAN",3891,"Q99848","EBP2_HUMAN","Probable rRNA-processing protein EBP2",null,"EBNA1BP2"]
["16.2159",1,"11.8073",1,{"$nulls":3},"muscle contraction","actin filament binding;ATP binding;calmodulin binding;microfilament motor activity","extracellular exosome;muscle myosin complex;myofibril;myosin filament","Tight junction",null,null,7,6,5,"4.6","4.2","3.8","223.6",0,"22.05",50420000,13,"0.0781827",1,"2.20431","0.236217","sp|Q9UKX3|MYH13_HUMAN;sp|P12883|MYH7_HUMAN;sp|A7E2Y1|MYH7B_HUMAN;tr|A0A087X0T3|A0A087X0T3_HUMAN","sp|Q9UKX3|MYH13_HUMAN",4796,"Q9UKX3","MYH13_HUMAN","Myosin-13",null,"MYH13"]
["16.0644","17.6651","14.14","15.3918",{"$nulls":3},"spermatid development;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","DNA binding transcription factor activity","fibrillar center;nucleoplasm;nucleus;transcription elongation factor complex;transcriptionally active chromatin",{"$nulls":3},16,16,16,"19.1","19.1","19.1","127.46",0,"65.172",511400000,84,"0.757344",1,"2.09888","2.06572","sp|Q9UHB7|AFF4_HUMAN;tr|C9JCE0|C9JCE0_HUMAN;tr|H7C319|H7C319_HUMAN","sp|Q9UHB7|AFF4_HUMAN",4718,"Q9UHB7","AFF4_HUMAN","AF4/FMR2 family member 4",null,"AFF4"]
["16.3477","18.0094","14.5825","15.6363",{"$nulls":3},"apoptotic process;cell differentiation;cell proliferation;cellular response to interferon-beta;defense response to virus;mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;regulation of type I interferon production;RNA secondary structure unwinding","ATP binding;ATP-dependent RNA helicase activity;DNA binding;metal ion binding;RNA binding","catalytic step 2 spliceosome;cytoplasm;cytosol;endoplasmic reticulum;membrane;nucleolus;nucleus",{"$nulls":3},17,17,14,"35.2","35.2","29.9","69.837",0,"39.668",480520000,61,"0.76913",1,"2.06915","2.10313","sp|Q9UJV9|DDX41_HUMAN;tr|J3KNN5|J3KNN5_HUMAN;tr|H0Y8L8|H0Y8L8_HUMAN;tr|D6RGI7|D6RGI7_HUMAN;tr|D6RD33|D6RD33_HUMAN","sp|Q9UJV9|DDX41_HUMAN;tr|J3KNN5|J3KNN5_HUMAN",4770,"Q9UJV9","DDX41_HUMAN","Probable ATP-dependent RNA helicase DDX41",null,"DDX41"]
["19.3209","16.7935","16.7275","15.258",{"$nulls":3},"cellular iron ion homeostasis;copper ion transport;iron ion transport","copper ion binding;ferrous iron binding;ferroxidase activity","basolateral plasma membrane;integral component of membrane;intracellular;perinuclear region of cytoplasm;plasma membrane","Mineral absorption;Porphyrin and chlorophyll metabolism",null,null,5,5,5,"6.3","6.3","6.3","130.45","0.00025661","6.9413",123560000,15,"0.532576",1,"2.06448","1.41229","sp|Q9BQS7|HEPH_HUMAN;tr|A0A0C4DG76|A0A0C4DG76_HUMAN;tr|Q5JZ08|Q5JZ08_HUMAN;tr|E7ES21|E7ES21_HUMAN;tr|Q5JZ07|Q5JZ07_HUMAN;tr|F8WBZ8|F8WBZ8_HUMAN","sp|Q9BQS7|HEPH_HUMAN;tr|A0A0C4DG76|A0A0C4DG76_HUMAN;tr|Q5JZ08|Q5JZ08_HUMAN;tr|E7ES21|E7ES21_HUMAN;tr|Q5JZ07|Q5JZ07_HUMAN",3924,"Q9BQS7","HEPH_HUMAN","Hephaestin",null,"HEPH"]
[1,"18.1947",1,"14.0801",{"$nulls":3},"DNA repair;meiotic cell cycle;mitotic cell cycle checkpoint;telomere maintenance",null,"chromosome, telomeric region;Mre11 complex",{"$nulls":3},2,2,2,"3.9","3.9","3.9","75.968","0.00067935","4.3406",27885000,3,"0.0622141",1,"2.05729","0.190452","tr|A0A0C4DG07|A0A0C4DG07_HUMAN;sp|O60934|NBN_HUMAN;tr|A0A087X1V5|A0A087X1V5_HUMAN","tr|A0A0C4DG07|A0A0C4DG07_HUMAN;sp|O60934|NBN_HUMAN;tr|A0A087X1V5|A0A087X1V5_HUMAN",516,"A0A0C4DG07","A0A0C4DG07_HUMAN","Nibrin {ECO:0000256|PIRNR:PIRNR011869}"]
["18.6795","20.1746","17.61","17.1325",{"$nulls":3},"chemical synaptic transmission;endothelial cell migration;glutamate secretion;G-protein coupled receptor signaling pathway;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of cytokinesis;positive regulation of transforming growth factor beta receptor signaling pathway;protein targeting;regulation of protein stability;regulation of synaptic plasticity","actin binding;cadherin binding;myosin binding;PDZ domain binding;protein homodimerization activity;receptor binding","brush border;cell cortex;cytoplasm;cytoplasmic vesicle;cytosol;dendritic shaft;dendritic spine;endocytic vesicle;extracellular exosome;membrane;synaptic vesicle;vesicle membrane",{"$nulls":3},3,3,3,"9.3","9.3","9.3","36.049",0,"10.01",108530000,19,"0.920668",1,"2.0558","2.61961","sp|O14908|GIPC1_HUMAN;tr|K7EM11|K7EM11_HUMAN;tr|K7ELJ2|K7ELJ2_HUMAN","sp|O14908|GIPC1_HUMAN;tr|K7EM11|K7EM11_HUMAN",298,"O14908","GIPC1_HUMAN","PDZ domain-containing protein GIPC1",null,"GIPC1"]
["19.5123","19.9826","19.5428","16.0468",{"$nulls":3},"mRNA splice site selection;negative regulation of striated muscle tissue development","identical protein binding;mRNA binding;RS domain binding","U1 snRNP;U2-type prespliceosome",{"$nulls":3},9,4,4,"25.1","16.2","16.2","43.727",0,"37.012",363660000,29,"0.416146",1,"1.95263","1.1071","sp|Q9NQ29|LUC7L_HUMAN;tr|A8MYV2|A8MYV2_HUMAN;tr|B8ZZ10|B8ZZ10_HUMAN;tr|B8ZZ09|B8ZZ09_HUMAN;tr|F8WBC1|F8WBC1_HUMAN;tr|F2Z322|F2Z322_HUMAN","sp|Q9NQ29|LUC7L_HUMAN;tr|A8MYV2|A8MYV2_HUMAN;tr|B8ZZ10|B8ZZ10_HUMAN",4377,"Q9NQ29","LUC7L_HUMAN","Putative RNA-binding protein Luc7-like 1",null,"LUC7L"]
["17.6153","18.1966","13.8531","18.1266",{"$nulls":3},"lipid metabolic process;proteolysis;regulation of lipid metabolic process","identical protein binding;peptidase activity","cytosol;mitochondrion",{"$nulls":3},19,19,19,"45.5","45.5","45.5","60.693",0,"106.93",1248200000,94,"0.329761",1,"1.91608","0.888551","sp|P83111|LACTB_HUMAN;tr|H0YNN5|H0YNN5_HUMAN","sp|P83111|LACTB_HUMAN",2002,"P83111","LACTB_HUMAN","Serine beta-lactamase-like protein LACTB, mitochondrial {ECO:0000305}",null,"LACTB"]
["17.8122","19.9834","17.866","16.1321",{"$nulls":5},"nuclear membrane;nucleus",{"$nulls":3},14,14,13,22,22,"20.6","105.85",0,"49.571",518050000,52,"0.515586",1,"1.89874","1.36668","tr|H0Y3N9|H0Y3N9_HUMAN;sp|Q9UPP1|PHF8_HUMAN;tr|H0Y589|H0Y589_HUMAN;tr|H0Y7M8|H0Y7M8_HUMAN;tr|H7BZB7|H7BZB7_HUMAN","tr|H0Y3N9|H0Y3N9_HUMAN;sp|Q9UPP1|PHF8_HUMAN;tr|H0Y589|H0Y589_HUMAN",4866,"H0Y3N9","H0Y3N9_HUMAN",null,null,"PHF8"]
["19.7024","17.7496","18.4669","15.2693",{"$nulls":3},"cell cycle;cell division;cellular response to DNA damage stimulus;negative regulation by host of viral genome replication;negative regulation of cell cycle arrest;positive regulation of cyclin-dependent protein serine/threonine kinase activity;positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues;positive regulation of transcription from RNA polymerase II promoter;regulation of cyclin-dependent protein serine/threonine kinase activity;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","cyclin-dependent protein serine/threonine kinase activity;cyclin-dependent protein serine/threonine kinase regulator activity;protein kinase binding;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity","cyclin K-CDK12 complex;cyclin K-CDK13 complex;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"16.7","16.7","16.7","64.239",0,"42.992",317000000,38,"0.370758",1,"1.85793","0.991757","sp|O75909|CCNK_HUMAN;tr|G3V5E1|G3V5E1_HUMAN;tr|G3V2Q3|G3V2Q3_HUMAN;tr|G3V235|G3V235_HUMAN","sp|O75909|CCNK_HUMAN;tr|G3V5E1|G3V5E1_HUMAN;tr|G3V2Q3|G3V2Q3_HUMAN",625,"O75909","CCNK_HUMAN","Cyclin-K",null,"CCNK"]
["18.7102","18.1359","18.0008","15.1463",{"$nulls":3},"regulation of transcription, DNA-templated",null,"nucleoplasm",{"$nulls":3},4,4,4,"8.6","8.6","8.6","74.9",0,"16.99",108850000,17,"0.479213",1,"1.84952","1.2704","tr|F5H7D6|F5H7D6_HUMAN;tr|H0YNT2|H0YNT2_HUMAN;sp|Q04726|TLE3_HUMAN;tr|H0YKT5|H0YKT5_HUMAN;tr|H0YKN8|H0YKN8_HUMAN;tr|H0YL70|H0YL70_HUMAN;tr|H0YKH0|H0YKH0_HUMAN;tr|H0YLW9|H0YLW9_HUMAN;tr|H0YLI3|H0YLI3_HUMAN;tr|A0A0D9SES8|A0A0D9SES8_HUMAN;tr|H0YNI7|H0YNI7_HUMAN","tr|F5H7D6|F5H7D6_HUMAN;tr|H0YNT2|H0YNT2_HUMAN;sp|Q04726|TLE3_HUMAN;tr|H0YKT5|H0YKT5_HUMAN;tr|H0YKN8|H0YKN8_HUMAN;tr|H0YL70|H0YL70_HUMAN;tr|H0YKH0|H0YKH0_HUMAN;tr|H0YLW9|H0YLW9_HUMAN;tr|H0YLI3|H0YLI3_HUMAN;tr|A0A0D9SES8|A0A0D9SES8_HUMAN;tr|H0YNI7|H0YNI7_HUMAN",2090,"F5H7D6","F5H7D6_HUMAN",null,null,"TLE3"]
[1,"20.1116","16.42",1,{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial ribosome;mitochondrial small ribosomal subunit","Ribosome",null,null,5,5,5,"39.1","39.1","39.1","15.173",0,"10.494",608910000,40,"0.0485188",1,"1.84581","0.150331","sp|O15235|RT12_HUMAN","sp|O15235|RT12_HUMAN",342,"O15235","RT12_HUMAN","28S ribosomal protein S12, mitochondrial","12mt;RP-S12","MRPS12"]
["18.001","17.2978","16.7502","14.9973",{"$nulls":3},"rRNA processing","RNA binding;snoRNA binding","Mpp10 complex;nucleolus;nucleoplasm;nucleus;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,6,6,6,"43.5","43.5","43.5","21.85",0,"16.639",303690000,46,"0.697217",1,"1.77564","1.88034","sp|Q9NV31|IMP3_HUMAN","sp|Q9NV31|IMP3_HUMAN",4477,"Q9NV31","IMP3_HUMAN","U3 small nucleolar ribonucleoprotein protein IMP3","3 snoRNP protein IMP3","IMP3"]
["16.0643","15.952","14.2412","14.2561",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;poly(A)+ mRNA export from nucleus;RNA export from nucleus;termination of RNA polymerase II transcription","metal ion binding;RNA binding","nucleoplasm",{"$nulls":3},4,4,4,"8.1","8.1","8.1","89.13",0,"25.651",78527000,30,"2.98532",1,"1.75948","31.0689","sp|O75152|ZC11A_HUMAN;tr|E9PQ61|E9PQ61_HUMAN;tr|E9PBY7|E9PBY7_HUMAN","sp|O75152|ZC11A_HUMAN;tr|E9PQ61|E9PQ61_HUMAN",530,"O75152","ZC11A_HUMAN","Zinc finger CCCH domain-containing protein 11A",null,"ZC3H11A"]
["20.553","22.5548","20.7325","18.9568",{"$nulls":3},"cardiovascular system development;fatty acid metabolic process;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;mitochondrion morphogenesis;multicellular organism aging;multicellular organism growth;muscle contraction;reproductive system development","electron transfer activity;NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex I","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,5,5,5,54,54,54,"13.711",0,"41.987",165730000,11,"0.481934",1,"1.70926","1.27754","sp|O75380|NDUS6_HUMAN;tr|D6RBT3|D6RBT3_HUMAN","sp|O75380|NDUS6_HUMAN;tr|D6RBT3|D6RBT3_HUMAN",557,"O75380","NDUS6_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial",null,"NDUFS6"]
["20.7652","21.6999","17.9734","21.0841",{"$nulls":9},5,5,5,"25.4","25.4","25.4","18.657",0,"10.589",125930000,13,"0.393387",1,"1.70376","1.04908","tr|H0Y6Y8|H0Y6Y8_HUMAN;tr|B1AL05|B1AL05_HUMAN;sp|Q8N983|RM43_HUMAN;tr|H0YBU8|H0YBU8_HUMAN;tr|M0R051|M0R051_HUMAN","tr|H0Y6Y8|H0Y6Y8_HUMAN;tr|B1AL05|B1AL05_HUMAN;sp|Q8N983|RM43_HUMAN;tr|H0YBU8|H0YBU8_HUMAN",3266,"H0Y6Y8","H0Y6Y8_HUMAN",null,null,"MRPL43"]
["22.3797","22.4679","22.0526","19.3903",{"$nulls":3},"chromatin organization;positive regulation of DNA-templated transcription, elongation;positive regulation of NAD+ ADP-ribosyltransferase activity;post-embryonic camera-type eye morphogenesis;pyrimidine dimer repair by nucleotide-excision repair;regulation of development, heterochronic;regulation of epithelial cell proliferation;regulation of transcription from RNA polymerase II promoter;response to UV-B;response to UV-C;transcription-coupled nucleotide-excision repair","DNA binding;nucleosomal DNA binding","chromatin;cytoplasm;nucleoplasm;nucleus",{"$nulls":3},5,5,5,47,47,47,"10.659",0,"18.282",247290000,19,"0.482181",1,"1.70239","1.27819","sp|P05114|HMGN1_HUMAN;tr|A6NL93|A6NL93_HUMAN;tr|A6NEL0|A6NEL0_HUMAN;tr|F2Z2W6|F2Z2W6_HUMAN;tr|F2Z2Y5|F2Z2Y5_HUMAN;tr|H7BXJ5|H7BXJ5_HUMAN","sp|P05114|HMGN1_HUMAN;tr|A6NL93|A6NL93_HUMAN;tr|A6NEL0|A6NEL0_HUMAN",856,"P05114","HMGN1_HUMAN","Non-histone chromosomal protein HMG-14",null,"HMGN1"]
["18.8064","22.6198","18.9672","19.0947",{"$nulls":3},"tRNA aminoacylation for protein translation;tryptophanyl-tRNA aminoacylation;vasculogenesis","ATP binding;tryptophan-tRNA ligase activity","mitochondrial matrix;mitochondrion;plasma membrane","Aminoacyl-tRNA biosynthesis",null,null,5,5,5,"19.4","19.4","19.4","40.146",0,"10.78",194760000,15,"0.327039",1,"1.68214","0.88172","sp|Q9UGM6|SYWM_HUMAN","sp|Q9UGM6|SYWM_HUMAN",4705,"Q9UGM6","SYWM_HUMAN","Tryptophan--tRNA ligase, mitochondrial",null,"WARS2"]
["16.5308","17.2315","16.1369","14.2728",{"$nulls":3},"aging;extracellular matrix organization;follicular dendritic cell differentiation;germinal center formation;I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;negative regulation of transcription from RNA polymerase II promoter;NIK/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;regulation of transcription, DNA-templated;response to cytokine;response to lipopolysaccharide;rhythmic process;spleen development","chromatin binding;DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcription coactivator activity;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","Bcl3/NF-kappaB2 complex;cytoplasm;cytosol;nucleoplasm;nucleus","Breast cancer;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Human T-cell leukemia virus 1 infection;Legionellosis;MAPK signaling pathway;NF-kappa B signaling pathway;Osteoclast differentiation;Pathways in cancer;Viral carcinogenesis",null,null,2,2,2,"3.3","3.3","3.3","96.748",0,"11.397",30345000,11,"0.630194",1,"1.67632","1.68347","sp|Q00653|NFKB2_HUMAN","sp|Q00653|NFKB2_HUMAN",2034,"Q00653","NFKB2_HUMAN","Nuclear factor NF-kappa-B p100 subunit",null,"NFKB2"]
["16.3277","16.5988","14.5688","15.0662",{"$nulls":3},"negative regulation of protein localization to nucleolus;positive regulation of gene expression, epigenetic;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription initiation from RNA polymerase I promoter","chromatin binding;DNA binding;RNA polymerase I activity;zinc ion binding","DNA-directed RNA polymerase I complex;nucleoplasm","RNA polymerase",null,null,34,34,33,"26.5","26.5","25.9","194.81",0,"123.73",1228900000,151,"1.54713",1,"1.64572","5.8099","sp|O95602|RPA1_HUMAN;tr|B9ZVN9|B9ZVN9_HUMAN","sp|O95602|RPA1_HUMAN;tr|B9ZVN9|B9ZVN9_HUMAN",746,"O95602","RPA1_HUMAN","DNA-directed RNA polymerase I subunit RPA1","NA polymerase I subunit A1","POLR1A"]
["17.0961","17.5237","16.068","15.2687",{"$nulls":3},"mitotic cell cycle",null,"chromosome, centromeric region;nucleus",{"$nulls":3},3,3,3,"7.2","7.2","7.2","48.832","0.00023827","5.3749",29068000,7,"1.1643",1,"1.64157","3.6216","tr|E9PQC4|E9PQC4_HUMAN;sp|Q9BZD4|NUF2_HUMAN;tr|B1AQT4|B1AQT4_HUMAN;tr|E9PP32|E9PP32_HUMAN","tr|E9PQC4|E9PQC4_HUMAN;sp|Q9BZD4|NUF2_HUMAN",4072,"E9PQC4","E9PQC4_HUMAN",null,null,"NUF2"]
["21.2242","21.4609","21.4226","18.008",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;movement of cell or subcellular component;response to estradiol;response to estrogen","actin binding;protein complex binding;structural constituent of cytoskeleton","actin cytoskeleton;Arp2/3 protein complex;cytosol;extracellular exosome;focal adhesion;tubulobulbar complex","Bacterial invasion of epithelial cells;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,5,5,5,"19.6","19.6","19.6","40.949",0,"23.532",411130000,35,"0.354535",1,"1.62726","0.950834","sp|O15143|ARC1B_HUMAN;tr|C9JTT6|C9JTT6_HUMAN;tr|C9JBJ7|C9JBJ7_HUMAN;tr|C9K057|C9K057_HUMAN;tr|C9J4Z7|C9J4Z7_HUMAN;tr|F8VXW2|F8VXW2_HUMAN;tr|C9JEY1|C9JEY1_HUMAN;tr|C9JQM8|C9JQM8_HUMAN;tr|C9JFG9|C9JFG9_HUMAN;tr|C9J6C8|C9J6C8_HUMAN;tr|C9JM51|C9JM51_HUMAN;tr|F8WEB3|F8WEB3_HUMAN","sp|O15143|ARC1B_HUMAN;tr|C9JTT6|C9JTT6_HUMAN;tr|C9JBJ7|C9JBJ7_HUMAN;tr|C9K057|C9K057_HUMAN;tr|C9J4Z7|C9J4Z7_HUMAN;tr|F8VXW2|F8VXW2_HUMAN;tr|C9JEY1|C9JEY1_HUMAN;tr|C9JQM8|C9JQM8_HUMAN;tr|C9JFG9|C9JFG9_HUMAN;tr|C9J6C8|C9J6C8_HUMAN",329,"O15143","ARC1B_HUMAN","Actin-related protein 2/3 complex subunit 1B",null,"ARPC1B"]
["16.9966",1,1,"13.7905",{"$nulls":3},"RNA secondary structure unwinding;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;nucleolus;nucleoplasm",{"$nulls":3},7,7,7,"20.7","20.7","20.7","54.226",0,"23.84",190480000,22,"0.0506184",1,"1.60306","0.156538","sp|Q9Y6V7|DDX49_HUMAN;tr|M0R1S3|M0R1S3_HUMAN;tr|M0QZC0|M0QZC0_HUMAN;tr|M0R0K1|M0R0K1_HUMAN","sp|Q9Y6V7|DDX49_HUMAN",5115,"Q9Y6V7","DDX49_HUMAN","Probable ATP-dependent RNA helicase DDX49",null,"DDX49"]
["25.1445","25.3348","24.911","22.3834",{"$nulls":3},"spliceosomal snRNP assembly",null,"spliceosomal complex",{"$nulls":3},3,3,3,"31.2","31.2","31.2","7.1013",0,"9.9952",843100000,24,"0.473907",1,"1.59246","1.25649","tr|Q49AN9|Q49AN9_HUMAN;tr|F5H013|F5H013_HUMAN;sp|P62308|RUXG_HUMAN;sp|A8MWD9|RUXGL_HUMAN;tr|C9JVQ0|C9JVQ0_HUMAN","tr|Q49AN9|Q49AN9_HUMAN;tr|F5H013|F5H013_HUMAN;sp|P62308|RUXG_HUMAN;sp|A8MWD9|RUXGL_HUMAN",178,"Q49AN9","Q49AN9_HUMAN"]
["17.2324","18.153","15.9075","16.3374",{"$nulls":9},6,6,6,"21.6","21.6","21.6","38.62",0,"31.037",727600000,52,"1.04252",1,"1.57025","3.09071","tr|F5GX09|F5GX09_HUMAN;sp|Q5HYJ3|FA76B_HUMAN","tr|F5GX09|F5GX09_HUMAN;sp|Q5HYJ3|FA76B_HUMAN",2690,"F5GX09","F5GX09_HUMAN",null,null,"FAM76B"]
["19.6526","19.2554","20.1245","15.6552",{"$nulls":4},"calcium ion binding",{"$nulls":4},7,7,7,"22.3","22.3","22.3","46.629",0,"16.651",162330000,18,"0.253503",1,"1.56414","0.697192","tr|Q2L696|Q2L696_HUMAN;tr|V9HW75|V9HW75_HUMAN;tr|A0A087WSV8|A0A087WSV8_HUMAN;sp|P80303|NUCB2_HUMAN;tr|E9PKG6|E9PKG6_HUMAN;tr|E9PM22|E9PM22_HUMAN;tr|E9PLR0|E9PLR0_HUMAN;tr|E9PLE9|E9PLE9_HUMAN;tr|E9PJP3|E9PJP3_HUMAN;tr|H0YEG8|H0YEG8_HUMAN","tr|Q2L696|Q2L696_HUMAN;tr|V9HW75|V9HW75_HUMAN;tr|A0A087WSV8|A0A087WSV8_HUMAN;sp|P80303|NUCB2_HUMAN;tr|E9PKG6|E9PKG6_HUMAN;tr|E9PM22|E9PM22_HUMAN;tr|E9PLR0|E9PLR0_HUMAN;tr|E9PLE9|E9PLE9_HUMAN",1984,"Q2L696","Q2L696_HUMAN",null,null,"NUCB2"]
["18.5942","16.2177","18.8294","12.8864",{"$nulls":3},"cell differentiation","RNA binding","cytoplasm;extracellular exosome;membrane;nucleus",{"$nulls":3},12,11,11,10,"9.6","9.6","228.86",0,"17.451",214510000,22,"0.169816",1,"1.54802","0.483716","sp|P48634|PRC2A_HUMAN","sp|P48634|PRC2A_HUMAN",1546,"P48634","PRC2A_HUMAN","Protein PRRC2A",null,"PRRC2A"]
["17.227","17.3196","18.5369","12.9207",{"$nulls":3},"centrosome duplication;cytoplasmic microtubule organization;interphase microtubule nucleation by interphase microtubule organizing center;meiotic cell cycle;microtubule nucleation;mitotic spindle assembly;protein complex assembly","gamma-tubulin binding;structural constituent of cytoskeleton","centrosome;cytosol;equatorial microtubule organizing center;gamma-tubulin complex;gamma-tubulin ring complex;membrane;microtubule;microtubule cytoskeleton;recycling endosome;spindle pole",{"$nulls":3},16,16,16,36,36,36,"76.088",0,"85.254",662830000,78,"0.195482",1,"1.54456","0.549968","sp|Q9UGJ1|GCP4_HUMAN;tr|H3BPU4|H3BPU4_HUMAN;tr|H3BN56|H3BN56_HUMAN;tr|H3BS59|H3BS59_HUMAN;tr|H3BNL9|H3BNL9_HUMAN;tr|H3BQ12|H3BQ12_HUMAN;tr|H3BQY4|H3BQY4_HUMAN","sp|Q9UGJ1|GCP4_HUMAN;tr|H3BPU4|H3BPU4_HUMAN",4703,"Q9UGJ1","GCP4_HUMAN","Gamma-tubulin complex component 4","CP-4;GCP4","TUBGCP4"]
["18.0501","16.9638","16.6945","15.2439",{"$nulls":3},"cellular response to acidic pH;insulin secretion involved in cellular response to glucose stimulus;negative regulation of adiponectin secretion;regulated exocytosis;regulation of protein localization to cell surface","gamma-tubulin binding;Rab GTPase binding","early endosome;early endosome membrane;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle;microtubule organizing center;mitochondrial outer membrane;recycling endosome;recycling endosome membrane;secretory granule;transport vesicle membrane","Endocytosis",null,null,15,15,15,"39.4","39.4","39.4","70.414",0,"87.054",756370000,99,"0.634897",1,"1.53771","1.69697","sp|Q9BXF6|RFIP5_HUMAN","sp|Q9BXF6|RFIP5_HUMAN",4040,"Q9BXF6","RFIP5_HUMAN","Rab11 family-interacting protein 5","ab11-FIP5","RAB11FIP5"]
["20.8168","19.7533","19.4834","18.0153",{"$nulls":3},"cell differentiation;DNA replication initiation;DNA unwinding involved in DNA replication;negative regulation of transcription, DNA-templated;nervous system development;positive regulation of cell proliferation;transcription, DNA-templated","double-stranded telomeric DNA binding;purine-rich negative regulatory element binding;RNA binding;single-stranded DNA binding;SMAD binding;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;transcription factor binding;translation repressor activity, nucleic acid binding","cytoplasm;dendrite;DNA replication factor A complex;neuronal cell body;nuclear chromosome, telomeric region;nucleus",{"$nulls":3},4,4,4,"10.9","10.9","10.9","34.91",0,"8.6506",79244000,15,"0.633942",1,"1.5357","1.69422","sp|Q00577|PURA_HUMAN","sp|Q00577|PURA_HUMAN",2032,"Q00577","PURA_HUMAN","Transcriptional activator protein Pur-alpha",null,"PURA"]
["16.9034","19.9999","17.1925","16.6477",{"$nulls":3},"negative regulation of epidermal growth factor-activated receptor activity;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding transcription factor activity;metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding;sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nucleus;plasma membrane",{"$nulls":3},4,4,3,"10.5","10.5","8.3","57.358","0.00025031","6.3872",56201000,11,"0.363822",1,"1.53156","0.974244","sp|Q8N5A5|ZGPAT_HUMAN;tr|V9GY48|V9GY48_HUMAN;tr|X6RGY1|X6RGY1_HUMAN","sp|Q8N5A5|ZGPAT_HUMAN;tr|V9GY48|V9GY48_HUMAN",3235,"Q8N5A5","ZGPAT_HUMAN","Zinc finger CCCH-type with G patch domain-containing protein",null,"ZGPAT"]
["21.3254","20.9448","20.5489","18.6721",{"$nulls":3},"base-excision repair;DNA damage response, detection of DNA damage;DNA replication;double-strand break repair via homologous recombination;error-free translesion synthesis;error-prone translesion synthesis;G1/S transition of mitotic cell cycle;interstrand cross-link repair;mismatch repair;mitotic G1 DNA damage checkpoint;nucleotide-excision repair;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;protein localization to chromosome;regulation of cellular response to heat;regulation of DNA damage checkpoint;regulation of double-strand break repair via homologous recombination;regulation of signal transduction by p53 class mediator;telomere maintenance;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","damaged DNA binding;enzyme binding;G-rich strand telomeric DNA binding;protein N-terminus binding;protein phosphatase binding;single-stranded DNA binding;ubiquitin protein ligase binding","chromatin;DNA replication factor A complex;nuclear body;nuclear chromosome, telomeric region;nucleoplasm;nucleus;PML body","DNA replication;Fanconi anemia pathway;Homologous recombination;Mismatch repair;Nucleotide excision repair",null,null,4,4,4,"27.8","27.8","27.8","29.247",0,"11.852",220880000,17,"0.598057",1,"1.5246","1.59232","sp|P15927|RFA2_HUMAN;tr|Q5TEJ7|Q5TEJ7_HUMAN;tr|Q5TEJ0|Q5TEJ0_HUMAN","sp|P15927|RFA2_HUMAN;tr|Q5TEJ7|Q5TEJ7_HUMAN",1068,"P15927","RFA2_HUMAN","Replication protein A 32 kDa subunit","P-A p32","RPA2"]
["21.5896","20.823","21.2076","18.1608",{"$nulls":3},"cell adhesion;cell-cell signaling;cell-matrix adhesion;cellular response to interferon-gamma;integrin-mediated signaling pathway;regulation of inflammatory response;signal transduction;stress fiber assembly;transforming growth factor beta receptor signaling pathway;viral process","metal ion binding;RNA binding","cell-cell adherens junction;cytosol;focal adhesion;integral component of plasma membrane;nucleus;phagocytic vesicle;plasma membrane;stress fiber","Focal adhesion",null,null,10,10,10,"34.4","34.4","34.4","61.277",0,"51.567",383100000,34,"0.361725",1,"1.52212","0.968955","sp|Q15942|ZYX_HUMAN;tr|H0Y2Y8|H0Y2Y8_HUMAN;tr|H7C3D3|H7C3D3_HUMAN;tr|C9IZ41|C9IZ41_HUMAN;tr|H7C3R3|H7C3R3_HUMAN;tr|C9JJK5|C9JJK5_HUMAN","sp|Q15942|ZYX_HUMAN;tr|H0Y2Y8|H0Y2Y8_HUMAN;tr|H7C3D3|H7C3D3_HUMAN",2533,"Q15942","ZYX_HUMAN","Zyxin",null,"ZYX"]
["21.1961","15.6618","17.1143","16.7155",{"$nulls":3},"activation of protein kinase B activity;establishment or maintenance of actin cytoskeleton polarity;negative regulation of Ras protein signal transduction;stress-activated protein kinase signaling cascade;substantia nigra development;TORC2 signaling","phosphatidic acid binding;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-4,5-bisphosphate binding;protein kinase binding;Ras GTPase binding","cytoplasmic vesicle;cytosol;Golgi apparatus;nucleoplasm;plasma membrane;TORC2 complex","mTOR signaling pathway",null,null,7,7,7,"15.5","15.5","15.5","59.122",0,"16.643",186510000,14,"0.193835",1,"1.51407","0.545745","sp|Q9BPZ7|SIN1_HUMAN;tr|E9PGB8|E9PGB8_HUMAN;tr|B1AMA5|B1AMA5_HUMAN;tr|B1AMA6|B1AMA6_HUMAN;tr|B1AMB1|B1AMB1_HUMAN;tr|B1AMB2|B1AMB2_HUMAN;tr|H0Y866|H0Y866_HUMAN","sp|Q9BPZ7|SIN1_HUMAN;tr|E9PGB8|E9PGB8_HUMAN;tr|B1AMA5|B1AMA5_HUMAN",3906,"Q9BPZ7","SIN1_HUMAN","Target of rapamycin complex 2 subunit MAPKAP1","ORC2 subunit MAPKAP1","MAPKAP1"]
["18.6054","19.8549","18.7945","16.6468",{"$nulls":3},"cardiolipin biosynthetic process","phosphatidylglycerophosphatase activity;phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;protein tyrosine phosphatase activity;protein tyrosine/serine/threonine phosphatase activity","mitochondrial inner membrane;mitochondrion;nucleus",{"$nulls":3},7,7,7,"42.3","42.3","42.3","22.843",0,"20.405",307190000,38,"0.457994",1,"1.50946","1.21499","sp|Q8WUK0|PTPM1_HUMAN;tr|E9PQM0|E9PQM0_HUMAN","sp|Q8WUK0|PTPM1_HUMAN",3423,"Q8WUK0","PTPM1_HUMAN","Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1",null,"PTPMT1"]
["21.2032","21.1599","21.1199","18.2337",{"$nulls":3},"cell division;microtubule-based movement;mitotic metaphase plate congression;mitotic sister chromatid segregation;mitotic spindle assembly;spermatogenesis","ATP binding;ATPase activity;microtubule binding;microtubule motor activity","early endosome;kinesin complex;membrane;microtubule;microtubule organizing center;nucleus;spindle",{"$nulls":3},10,10,8,18,18,"14.1","73.747",0,"53.894",896660000,51,"0.390842",1,"1.50476","1.04262","sp|Q9BW19|KIFC1_HUMAN;tr|A2AB20|A2AB20_HUMAN","sp|Q9BW19|KIFC1_HUMAN",4020,"Q9BW19","KIFC1_HUMAN","Kinesin-like protein KIFC1",null,"KIFC1"]
["19.1307","19.0926","19.3171","15.9214",{"$nulls":3},"mitochondrial threonyl-tRNA aminoacylation","aminoacyl-tRNA editing activity;ATP binding;protein homodimerization activity;threonine-tRNA ligase activity","mitochondrial matrix;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,15,15,15,"26.5","26.5","26.5","81.035",0,"40.771",218700000,26,"0.325928",1,"1.49238","0.878931","sp|Q9BW92|SYTM_HUMAN;tr|U3KQG0|U3KQG0_HUMAN;tr|F6S7Q7|F6S7Q7_HUMAN;tr|U3KQ50|U3KQ50_HUMAN;tr|Q5T5E9|Q5T5E9_HUMAN","sp|Q9BW92|SYTM_HUMAN;tr|U3KQG0|U3KQG0_HUMAN",4028,"Q9BW92","SYTM_HUMAN","Threonine--tRNA ligase, mitochondrial",null,"TARS2"]
["17.1405","16.503","17.2138","13.464",{"$nulls":5},"integral component of membrane;nuclear membrane;nucleoplasm",{"$nulls":3},10,10,10,"13.2","13.2","13.2","125.09",0,"26.62",152460000,31,"0.28635",1,"1.48281","0.779692","tr|A0A075B7F8|A0A075B7F8_HUMAN;sp|A8CG34|P121C_HUMAN;sp|Q96HA1|P121A_HUMAN;tr|A0A087WY75|A0A087WY75_HUMAN;sp|A6NF01|P121B_HUMAN;tr|C9JFL1|C9JFL1_HUMAN;tr|C9JER0|C9JER0_HUMAN;sp|Q6PJE2|POZP3_HUMAN;tr|C9J370|C9J370_HUMAN;tr|A0A0J9YWR1|A0A0J9YWR1_HUMAN","tr|A0A075B7F8|A0A075B7F8_HUMAN;sp|A8CG34|P121C_HUMAN;sp|Q96HA1|P121A_HUMAN;tr|A0A087WY75|A0A087WY75_HUMAN",176,"A0A075B7F8","A0A075B7F8_HUMAN",null,null,"POM121C"]
["20.4274","22.3557","21.2733","18.561",{"$nulls":3},"cell proliferation;cellular heat acclimation;CENP-A containing nucleosome assembly;DNA replication;multicellular organism development;negative regulation of cell growth;negative regulation of G0 to G1 transition;negative regulation of gene expression, epigenetic;negative regulation of transcription from RNA polymerase II promoter;post-translational protein modification;regulation of signal transduction by p53 class mediator;response to steroid hormone;transcription, DNA-templated","histone deacetylase activity;RNA binding","cytosol;ESC/E(Z) complex;nucleoplasm;nucleus;NuRD complex",{"$nulls":3},11,4,4,"26.8","14.4","14.4","47.82",0,"31.843",450270000,34,"0.32878",1,"1.47442","0.886089","sp|Q16576|RBBP7_HUMAN;tr|E9PC52|E9PC52_HUMAN;tr|Q5JP01|Q5JP01_HUMAN;tr|Q5JNZ6|Q5JNZ6_HUMAN","sp|Q16576|RBBP7_HUMAN;tr|E9PC52|E9PC52_HUMAN",2552,"Q16576","RBBP7_HUMAN","Histone-binding protein RBBP7",null,"RBBP7"]
["15.8958","17.9412","15.9372","14.9521",{"$nulls":3},"endoplasmic reticulum mannose trimming;mannose trimming involved in glycoprotein ERAD pathway;N-glycan processing;oligosaccharide metabolic process;protein alpha-1,2-demannosylation;protein glycosylation;trimming of first mannose on A branch;trimming of second mannose on A branch;trimming of terminal mannose on B branch;trimming of terminal mannose on C branch;ubiquitin-dependent ERAD pathway","calcium ion binding;mannosyl-oligosaccharide 1,2-alpha-mannosidase activity","endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum quality control compartment;extracellular vesicle;Golgi apparatus;Golgi membrane;integral component of membrane;membrane","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,9,9,9,18,18,18,"79.579",0,"65.266",250600000,31,"0.48984",1,"1.47384","1.29835","sp|Q9UKM7|MA1B1_HUMAN;tr|H0YGV7|H0YGV7_HUMAN;tr|H0YG20|H0YG20_HUMAN;REV__sp|O60290|ZN862_HUMAN","sp|Q9UKM7|MA1B1_HUMAN;tr|H0YGV7|H0YGV7_HUMAN;tr|H0YG20|H0YG20_HUMAN",4788,"Q9UKM7","MA1B1_HUMAN","Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase",null,"MAN1B1"]
["17.4564","17.3095","17.3323","14.4985",{"$nulls":3},"activation of protein kinase activity;apoptotic process;B cell proliferation;cell chemotaxis;cell cycle;cellular response to angiotensin;cellular response to hydrogen peroxide;cellular response to hydroperoxide;cellular senescence;defense response to bacterium;execution phase of apoptosis;Fc-gamma receptor signaling pathway involved in phagocytosis;histone phosphorylation;immunoglobulin mediated immune response;interferon-gamma-mediated signaling pathway;interleukin-10 production;interleukin-12 production;intrinsic apoptotic signaling pathway in response to oxidative stress;negative regulation of actin filament polymerization;negative regulation of filopodium assembly;negative regulation of glial cell apoptotic process;negative regulation of inflammatory response;negative regulation of insulin receptor signaling pathway;negative regulation of MAP kinase activity;negative regulation of peptidyl-tyrosine phosphorylation;negative regulation of platelet aggregation;negative regulation of protein binding;neutrophil activation;neutrophil degranulation;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;platelet activation;positive regulation of apoptotic signaling pathway;positive regulation of ceramide biosynthetic process;positive regulation of endodeoxyribonuclease activity;positive regulation of glucosylceramide catabolic process;positive regulation of phospholipid scramblase activity;positive regulation of protein dephosphorylation;positive regulation of protein import into nucleus;positive regulation of response to DNA damage stimulus;positive regulation of sphingomyelin catabolic process;positive regulation of superoxide anion generation;protein phosphorylation;protein stabilization;regulation of actin cytoskeleton organization;regulation of mRNA stability;regulation of receptor activity;signal transduction;stimulatory C-type lectin receptor signaling pathway;termination of signal transduction","ATP binding;calcium-independent protein kinase C activity;enzyme activator activity;enzyme binding;insulin receptor substrate binding;kinase binding;metal ion binding;non-membrane spanning protein tyrosine kinase activity;protein kinase activity;protein kinase binding;protein kinase C activity;protein serine/threonine kinase activity","azurophil granule lumen;cell-cell junction;cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;extracellular region;nuclear matrix;nucleoplasm;nucleus;perinuclear region of cytoplasm;plasma membrane","AGE-RAGE signaling pathway in diabetic complications;Autophagy - animal;Chemokine signaling pathway;C-type lectin receptor signaling pathway;Estrogen signaling pathway;Fc gamma R-mediated phagocytosis;GnRH signaling pathway;Inflammatory mediator regulation of TRP channels;Insulin resistance;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Type II diabetes mellitus;Vascular smooth muscle contraction",null,null,3,3,3,"6.2","6.2","6.2","77.504",0,"10.167",42925000,10,"0.387579",1,"1.46753","1.03434","sp|Q05655|KPCD_HUMAN","sp|Q05655|KPCD_HUMAN",2104,"Q05655","KPCD_HUMAN","Protein kinase C delta type",null,"PRKCD"]
["18.7341","19.279","19.2049","15.875",{"$nulls":3},"actin cytoskeleton reorganization;actin filament polymerization;bicellular tight junction assembly;endocytic recycling;neuron projection development;positive regulation of protein targeting to mitochondrion;substrate adhesion-dependent cell spreading","actin filament binding;actinin binding;filamin binding;metal ion binding;Rab GTPase binding","bicellular tight junction;cell-cell junction;cytosol;neuron projection;plasma membrane;recycling endosome;stress fiber","Tight junction",null,null,8,8,8,"16.5","16.5","16.5","97.501",0,"22.071",204000000,24,"0.322096",1,"1.46663","0.869317","sp|Q8IY33|MILK2_HUMAN","sp|Q8IY33|MILK2_HUMAN",3157,"Q8IY33","MILK2_HUMAN","MICAL-like protein 2",null,"MICALL2"]
["19.0389","19.1518","19.1122","16.1786",{"$nulls":3},"cell migration;lung alveolus development;positive regulation of cell proliferation",null,"cytosol;focal adhesion",{"$nulls":3},9,9,9,10,10,10,"155.26",0,"52.249",252480000,23,"0.369191",1,"1.44994","0.987799","sp|Q68CZ2|TENS3_HUMAN;tr|E9PCX8|E9PCX8_HUMAN;tr|C9JHU5|C9JHU5_HUMAN;tr|H0Y4U1|H0Y4U1_HUMAN;tr|F8VV64|F8VV64_HUMAN;tr|A0A087WWW7|A0A087WWW7_HUMAN;sp|Q63HR2|TNS2_HUMAN;tr|E9PGF5|E9PGF5_HUMAN;tr|E9PF55|E9PF55_HUMAN;sp|Q9HBL0|TENS1_HUMAN","sp|Q68CZ2|TENS3_HUMAN;tr|E9PCX8|E9PCX8_HUMAN",2792,"Q68CZ2","TENS3_HUMAN","Tensin-3",null,"TNS3"]
["19.0783","20.2583","19.141","17.3047",{"$nulls":9},2,2,2,"5.8","5.8","5.8","63.569","0.0023315","3.4036",138310000,4,"0.499721",1,"1.44551","1.32447","tr|H0YE03|H0YE03_HUMAN;tr|H7C3G7|H7C3G7_HUMAN;sp|Q2TBE0|C19L2_HUMAN","tr|H0YE03|H0YE03_HUMAN;tr|H7C3G7|H7C3G7_HUMAN;sp|Q2TBE0|C19L2_HUMAN",2605,"H0YE03","H0YE03_HUMAN",null,null,"CWF19L2"]
["18.7109","18.3516","18.5807","15.5923",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of translation;RNA export from nucleus;termination of RNA polymerase II transcription","mRNA binding;nucleocytoplasmic transporter activity;RNA binding","cytoplasm;cytosol;exon-exon junction complex;microtubule organizing center;nucleolus;nucleoplasm;nucleus","mRNA surveillance pathway;RNA transport",null,null,15,15,15,"29.4","29.4","29.4","57.761",0,"67.935",978380000,93,"0.358176",1,"1.44476","0.960009","sp|Q9BZI7|REN3B_HUMAN;tr|A0A087WYC8|A0A087WYC8_HUMAN","sp|Q9BZI7|REN3B_HUMAN;tr|A0A087WYC8|A0A087WYC8_HUMAN",4080,"Q9BZI7","REN3B_HUMAN","Regulator of nonsense transcripts 3B",null,"UPF3B"]
["19.5648","20.1589","17.2471","19.611",{"$nulls":3},"cell cycle arrest;cellular response to transforming growth factor beta stimulus;dephosphorylation;negative regulation of BMP signaling pathway;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of NF-kappaB import into nucleus;negative regulation of SMAD protein complex assembly;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transforming growth factor beta receptor signaling pathway;N-terminal protein myristoylation;peptidyl-threonine dephosphorylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of protein export from nucleus;positive regulation of transcription, DNA-templated;positive regulation of Wnt signaling pathway;protein dephosphorylation;Wnt signaling pathway","calmodulin-dependent protein phosphatase activity;magnesium ion binding;manganese ion binding;protein serine/threonine phosphatase activity;R-SMAD binding;signal transducer activity","cytosol;membrane;nucleoplasm;nucleus;plasma membrane","MAPK signaling pathway",null,null,5,5,3,17,17,"11.3","42.447",0,"11.003",145770000,15,"0.442834",1,"1.43283","1.1757","sp|P35813|PPM1A_HUMAN;tr|E9PKB5|E9PKB5_HUMAN;tr|E9PL75|E9PL75_HUMAN;tr|E9PJN3|E9PJN3_HUMAN","sp|P35813|PPM1A_HUMAN;tr|E9PKB5|E9PKB5_HUMAN",1397,"P35813","PPM1A_HUMAN","Protein phosphatase 1A",null,"PPM1A"]
["16.5049","16.8391","16.0802","14.4167",{"$nulls":4},"ATP binding;protein kinase activity",{"$nulls":4},30,19,1,"25.3","17.3","0.7","151.08",0,"79.435",818380000,103,"0.628296",1,"1.42354","1.67803","tr|A0A0D9SEY1|A0A0D9SEY1_HUMAN;tr|G5E948|G5E948_HUMAN;sp|O95819|M4K4_HUMAN;tr|H7C360|H7C360_HUMAN;tr|A0A0D9SG62|A0A0D9SG62_HUMAN;tr|E7ENQ1|E7ENQ1_HUMAN;tr|G3XAA2|G3XAA2_HUMAN;tr|E7EX83|E7EX83_HUMAN;tr|H7C0P6|H7C0P6_HUMAN;tr|H7C3Z6|H7C3Z6_HUMAN","tr|A0A0D9SEY1|A0A0D9SEY1_HUMAN;tr|G5E948|G5E948_HUMAN;sp|O95819|M4K4_HUMAN;tr|H7C360|H7C360_HUMAN;tr|A0A0D9SG62|A0A0D9SG62_HUMAN;tr|E7ENQ1|E7ENQ1_HUMAN;tr|G3XAA2|G3XAA2_HUMAN;tr|E7EX83|E7EX83_HUMAN;tr|H7C0P6|H7C0P6_HUMAN",5154,"A0A0D9SEY1","A0A0D9SEY1_HUMAN"]
["17.639",1,"14.8067",1,{"$nulls":3},"aorta smooth muscle tissue morphogenesis;bleb assembly;cellular hypotonic response;muscle contraction;positive regulation of calcium ion transport;positive regulation of cell migration;positive regulation of wound healing;protein phosphorylation;smooth muscle contraction;tonic smooth muscle contraction","actin binding;ATP binding;calmodulin binding;metal ion binding;myosin light chain kinase activity","cleavage furrow;cytoplasm;cytosol;extracellular exosome;lamellipodium;stress fiber","Apelin signaling pathway;Calcium signaling pathway;cGMP-PKG signaling pathway;Focal adhesion;Gastric acid secretion;Oxytocin signaling pathway;Platelet activation;Regulation of actin cytoskeleton;Vascular smooth muscle contraction",null,null,2,2,2,"1.2","1.2","1.2","210.71","0.0079953","2.3795",124760000,6,"0.0420263",1,"1.41617","0.130998","sp|Q15746|MYLK_HUMAN","sp|Q15746|MYLK_HUMAN",2517,"Q15746","MYLK_HUMAN","Myosin light chain kinase, smooth muscle","LCK;mMLCK","MYLK"]
["18.7169","18.8336","17.7621","16.9738",{"$nulls":3},"negative regulation of insulin secretion","cytokine activity","extracellular region",{"$nulls":3},3,3,3,17,17,17,"24.963","0.00069493","4.7644",46050000,11,"1.14469",1,"1.40729","3.53162","sp|Q96BQ1|FAM3D_HUMAN","sp|Q96BQ1|FAM3D_HUMAN",3618,"Q96BQ1","FAM3D_HUMAN","Protein FAM3D",null,"FAM3D"]
["18.3951","20.5523","17.3737","18.7629",{"$nulls":4},"metal ion binding;RNA binding","nucleolus;nucleus",{"$nulls":3},17,17,17,"47.2","47.2","47.2","43.614",0,"164.32",3273900000,198,"0.41159",1,"1.40539","1.09546","sp|Q9NX58|LYAR_HUMAN;tr|D6RDJ1|D6RDJ1_HUMAN","sp|Q9NX58|LYAR_HUMAN",4535,"Q9NX58","LYAR_HUMAN","Cell growth-regulating nucleolar protein",null,"LYAR"]
["16.9615","17.7354","16.4338","15.4584",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA polyadenylation;mRNA splicing, via spliceosome;pre-mRNA cleavage required for polyadenylation;termination of RNA polymerase II transcription","RNA binding","mRNA cleavage and polyadenylation specificity factor complex;nucleoplasm","mRNA surveillance pathway",null,null,6,6,6,"15.2","15.2","15.2","66.526",0,"11.147",95826000,13,"0.815059",1,"1.40232","2.25247","sp|Q6UN15|FIP1_HUMAN;tr|A0A0B4J203|A0A0B4J203_HUMAN;tr|H0Y8P7|H0Y8P7_HUMAN","sp|Q6UN15|FIP1_HUMAN;tr|A0A0B4J203|A0A0B4J203_HUMAN",2901,"Q6UN15","FIP1_HUMAN","Pre-mRNA 3'-end-processing factor FIP1","Fip1","FIP1L1"]
["17.6049","18.6871","16.8905","16.6315",{"$nulls":3},"cell division;cell proliferation;DNA repair;mitotic sister chromatid cohesion;negative regulation of cell proliferation;regulation of cell proliferation;sister chromatid cohesion","ATP binding;DNA binding","chromatin;chromosome;chromosome, centromeric region;cytosol;nucleoplasm;nucleus",{"$nulls":3},27,26,26,"22.3","21.8","21.8","164.67",0,"127.72",1143900000,146,"0.884386",1,"1.38499","2.48951","sp|Q9NTI5|PDS5B_HUMAN;tr|A9IYQ1|A9IYQ1_HUMAN","sp|Q9NTI5|PDS5B_HUMAN",4449,"Q9NTI5","PDS5B_HUMAN","Sister chromatid cohesion protein PDS5 homolog B",null,"PDS5B"]
[1,"19.376","16.6101",1,{"$nulls":9},1,1,1,"15.6","15.6","15.6","8.4658","0.0015116","3.6487",9569400,2,"0.0366133",1,"1.38294","0.114714","tr|C9JA90|C9JA90_HUMAN;tr|C9J5P1|C9J5P1_HUMAN;tr|C9IZY1|C9IZY1_HUMAN;tr|C9JNE2|C9JNE2_HUMAN;sp|Q9Y530|OARD1_HUMAN","tr|C9JA90|C9JA90_HUMAN;tr|C9J5P1|C9J5P1_HUMAN;tr|C9IZY1|C9IZY1_HUMAN;tr|C9JNE2|C9JNE2_HUMAN;sp|Q9Y530|OARD1_HUMAN",5029,"C9JA90","C9JA90_HUMAN",null,null,"OARD1"]
["19.7235","19.2605","18.5742","17.6463",{"$nulls":3},"abscission;actomyosin contractile ring contraction;cell division;cell separation after cytokinesis;cytoskeleton-dependent cytokinesis;endosomal transport;endosomal vesicle fusion;ESCRT complex disassembly;ESCRT III complex disassembly;intracellular cholesterol transport;late endosomal microautophagy;macroautophagy;mitotic cytokinesis checkpoint;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of cytokinesis;nuclear envelope organization;nuclear envelope reassembly;nucleus organization;positive regulation of exosomal secretion;positive regulation of viral budding via host ESCRT complex;positive regulation of viral life cycle;positive regulation of viral release from host cell;protein targeting to lysosome;regulation of protein localization;regulation of protein localization to plasma membrane;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;vesicle budding from membrane;vesicle uncoating;vesicle-mediated transport;viral budding via host ESCRT complex;viral life cycle;viral release from host cell","ATP binding;ATPase activity;ATPase activity, coupled;protein C-terminus binding;protein domain specific binding","centrosome;cytoplasm;cytosol;early endosome;endosome;extracellular exosome;Flemming body;late endosome;late endosome membrane;lysosome;midbody;nucleus;perinuclear region of cytoplasm;plasma membrane;spindle pole;vacuolar membrane","Endocytosis;Necroptosis",null,null,7,5,5,"17.6",13,13,"48.897","0.00026932","7.9756",110810000,16,"0.933061",1,"1.38176","2.66506","sp|Q9UN37|VPS4A_HUMAN;tr|I3L4J1|I3L4J1_HUMAN;sp|Q6PIW4|FIGL1_HUMAN","sp|Q9UN37|VPS4A_HUMAN;tr|I3L4J1|I3L4J1_HUMAN",4838,"Q9UN37","VPS4A_HUMAN","Vacuolar protein sorting-associated protein 4A",null,"VPS4A"]
["21.372","23.7684","22.193","20.1934",{"$nulls":3},"detection of chemical stimulus involved in sensory perception of bitter taste;negative regulation of cysteine-type endopeptidase activity","cysteine-type endopeptidase inhibitor activity;protease binding","extracellular space","Salivary secretion",null,null,5,5,5,"48.2","48.2","48.2","16.387",0,"34.313",237300000,32,"0.327295",1,"1.37698","0.882363","sp|P01037|CYTN_HUMAN;sp|P01036|CYTS_HUMAN;sp|P09228|CYTT_HUMAN","sp|P01037|CYTN_HUMAN",813,"P01037","CYTN_HUMAN","Cystatin-SN",null,"CST1"]
["24.2679","23.7144","24.3994","20.83",{"$nulls":9},2,2,2,"49.4","49.4","49.4","9.0564",0,"22.12",419970000,11,"0.279346",1,"1.37642","0.762125","sp|Q9P1F3|ABRAL_HUMAN;tr|Q5SZC9|Q5SZC9_HUMAN","sp|Q9P1F3|ABRAL_HUMAN;tr|Q5SZC9|Q5SZC9_HUMAN",4625,"Q9P1F3","ABRAL_HUMAN","Costars family protein ABRACL",null,"ABRACL"]
["21.3727","18.8782","18.8309","18.6778",{"$nulls":3},"androgen receptor signaling pathway;cell aging;cellular response to oxidative stress;cellular response to testosterone stimulus;cytoplasmic translation;positive regulation of androgen receptor activity",null,"cytoplasm;polysome",{"$nulls":3},2,2,2,7,7,7,"27.939","0.0067021","2.5218",41630000,7,"0.412274",1,"1.3711","1.09721","sp|Q9H446|RWDD1_HUMAN;tr|E5RJE3|E5RJE3_HUMAN;tr|E5RGS5|E5RGS5_HUMAN;tr|E5RGQ3|E5RGQ3_HUMAN","sp|Q9H446|RWDD1_HUMAN;tr|E5RJE3|E5RJE3_HUMAN;tr|E5RGS5|E5RGS5_HUMAN;tr|E5RGQ3|E5RGQ3_HUMAN",4200,"Q9H446","RWDD1_HUMAN","RWD domain-containing protein 1",null,"RWDD1"]
["20.9363","20.4391","21.1241","17.5298",{"$nulls":3},"ATP biosynthetic process;negative regulation of ATP citrate synthase activity;oxidative phosphorylation;positive regulation of high voltage-gated calcium channel activity",null,"integral component of plasma membrane;membrane;mitochondrial outer membrane;mitochondrion",{"$nulls":3},4,4,4,"13.6","13.6","13.6","33.742",0,"11.697",205850000,29,"0.274519",1,"1.36074","0.750011","sp|O75323|NIPS2_HUMAN;tr|H7C333|H7C333_HUMAN;tr|C9J7B1|C9J7B1_HUMAN;tr|C9K068|C9K068_HUMAN;tr|F8WBI5|F8WBI5_HUMAN","sp|O75323|NIPS2_HUMAN;tr|H7C333|H7C333_HUMAN;tr|C9J7B1|C9J7B1_HUMAN;tr|C9K068|C9K068_HUMAN",544,"O75323","NIPS2_HUMAN","Protein NipSnap homolog 2","ipSnap2","NIPSNAP2"]
["19.9683","20.8073","20.2142","17.8467",{"$nulls":3},"amyloid precursor protein catabolic process;amyloid precursor protein metabolic process;amyloid-beta formation;ephrin receptor signaling pathway;epithelial cell proliferation;membrane protein ectodomain proteolysis;membrane protein intracellular domain proteolysis;myeloid cell homeostasis;neutrophil degranulation;Notch receptor processing;Notch signaling pathway;positive regulation of apoptotic process;positive regulation of catalytic activity;protein processing;proteolysis;T cell proliferation","endopeptidase activity","azurophil granule membrane;endoplasmic reticulum;extracellular exosome;focal adhesion;gamma-secretase complex;Golgi apparatus;integral component of membrane;integral component of plasma membrane;lysosomal membrane;melanosome;membrane;plasma membrane","Alzheimer disease;Notch signaling pathway",null,null,9,9,9,"16.1","16.1","16.1","78.41",0,"29.935",376820000,23,"0.405858",1,"1.35738","1.08083","sp|Q92542|NICA_HUMAN;tr|H0Y6T7|H0Y6T7_HUMAN;tr|H0Y3Z4|H0Y3Z4_HUMAN;tr|Q5T205|Q5T205_HUMAN;tr|Q5T209|Q5T209_HUMAN;tr|Q5T210|Q5T210_HUMAN","sp|Q92542|NICA_HUMAN;tr|H0Y6T7|H0Y6T7_HUMAN;tr|H0Y3Z4|H0Y3Z4_HUMAN",3490,"Q92542","NICA_HUMAN","Nicastrin",null,"NCSTN"]
["20.7435","20.492","21.1692","17.3708",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"11.3","11.3","11.3","41.767",0,"40.839",146350000,8,"0.257827",1,"1.3477","0.708075","tr|A0A0C4DGH0|A0A0C4DGH0_HUMAN;sp|Q5ZPR3|CD276_HUMAN;tr|H0YK40|H0YK40_HUMAN;tr|H0YK59|H0YK59_HUMAN;tr|H0YL10|H0YL10_HUMAN","tr|A0A0C4DGH0|A0A0C4DGH0_HUMAN;sp|Q5ZPR3|CD276_HUMAN;tr|H0YK40|H0YK40_HUMAN;tr|H0YK59|H0YK59_HUMAN;tr|H0YL10|H0YL10_HUMAN",2778,"A0A0C4DGH0","A0A0C4DGH0_HUMAN",null,null,"CD276"]
["23.853","23.5512","23.8617","20.8671",{"$nulls":5},"integral component of membrane",{"$nulls":3},7,7,2,45,45,"9.5","20.542",0,"47.318",1386600000,67,"0.329895",1,"1.33769","0.888888","tr|A0A087WUV8|A0A087WUV8_HUMAN;sp|P35613|BASI_HUMAN;tr|R4GMX5|R4GMX5_HUMAN;tr|I3L192|I3L192_HUMAN;tr|R4GN83|R4GN83_HUMAN","tr|A0A087WUV8|A0A087WUV8_HUMAN;sp|P35613|BASI_HUMAN",1393,"A0A087WUV8","A0A087WUV8_HUMAN",null,null,"BSG"]
["14.5071","13.92","14.2741","11.4798",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;replication fork processing",null,"chromosome;nucleoplasm",{"$nulls":3},10,10,10,"4.5","4.5","4.5","330.46",0,"31.586",214490000,51,"0.348724",1,"1.33656","0.936207","sp|Q8NFC6|BD1L1_HUMAN;tr|H0Y9Y2|H0Y9Y2_HUMAN","sp|Q8NFC6|BD1L1_HUMAN",3335,"Q8NFC6","BD1L1_HUMAN","Biorientation of chromosomes in cell division protein 1-like 1 {ECO:0000305}",null,"BOD1L1"]
["17.8938","17.7306","17.5848","15.3838",{"$nulls":3},"actin filament organization;asymmetric neuroblast division;cell morphogenesis;cellular hyperosmotic response;cellular response to muramyl dipeptide;cellular response to tumor necrosis factor;establishment of mitotic spindle orientation;G-protein coupled receptor signaling pathway;innate immune response;intracellular protein transport;intracellular signal transduction;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;negative regulation of microtubule depolymerization;negative regulation of necroptotic process;negative regulation of neurogenesis;negative regulation of podosome assembly;positive regulation of apoptotic process;positive regulation of interleukin-6 production;positive regulation of neuron differentiation;positive regulation of neuron migration;positive regulation of NF-kappaB transcription factor activity;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor production;regulation of cell proliferation;regulation of Rho protein signal transduction;regulation of small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity;microtubule binding;Rac GTPase binding;Rac guanyl-nucleotide exchange factor activity;Rho GTPase binding;Rho guanyl-nucleotide exchange factor activity;transcription factor binding;zinc ion binding","bicellular tight junction;cytoplasm;cytoplasmic vesicle;cytoskeleton;cytosol;dendritic shaft;focal adhesion;Golgi apparatus;microtubule;neuronal cell body;podosome;postsynaptic density;protein complex;ruffle membrane;spindle;vesicle","Fluid shear stress and atherosclerosis;Pathogenic Escherichia coli infection;Tight junction",null,null,21,21,21,29,29,29,"111.54",0,"64.579",343600000,55,"0.45349",1,"1.32789","1.20329","sp|Q92974|ARHG2_HUMAN;tr|V9GYM8|V9GYM8_HUMAN;tr|Q5VY93|Q5VY93_HUMAN;tr|V9GYF0|V9GYF0_HUMAN;tr|V9GYF5|V9GYF5_HUMAN;tr|V9GYG5|V9GYG5_HUMAN;tr|V9GZ14|V9GZ14_HUMAN;tr|V9GZ58|V9GZ58_HUMAN","sp|Q92974|ARHG2_HUMAN;tr|V9GYM8|V9GYM8_HUMAN",3561,"Q92974","ARHG2_HUMAN","Rho guanine nucleotide exchange factor 2",null,"ARHGEF2"]
["18.5759","20.4391","18.9343","17.4299",{"$nulls":3},"regulation of phosphoprotein phosphatase activity;regulation of signal transduction","protein phosphatase inhibitor activity","cytosol;nucleoplasm",{"$nulls":3},3,3,3,20,20,20,"19.245","0.00026151","7.3042",39779000,10,"0.41608",1,"1.32541","1.10694","tr|E7EMN6|E7EMN6_HUMAN;sp|P41236|IPP2_HUMAN;tr|E7EUI7|E7EUI7_HUMAN;sp|Q6NXS1|IPP2M_HUMAN","tr|E7EMN6|E7EMN6_HUMAN;sp|P41236|IPP2_HUMAN;tr|E7EUI7|E7EUI7_HUMAN;sp|Q6NXS1|IPP2M_HUMAN",1455,"E7EMN6","E7EMN6_HUMAN",null,null,"PPP1R2"]
["17.9943","15.6349","16.9491","14.0505",{"$nulls":3},"mRNA processing;negative regulation of stem cell differentiation;phosphorylation of RNA polymerase II C-terminal domain;positive regulation of transcription from RNA polymerase II promoter;protein autophosphorylation;regulation of MAP kinase activity;regulation of RNA splicing;RNA splicing;transcription elongation from RNA polymerase II promoter","ATP binding;cyclin binding;cyclin-dependent protein serine/threonine kinase activity;protein kinase activity;protein kinase binding;RNA polymerase II carboxy-terminal domain kinase activity;transcription factor binding;transcription regulatory region DNA binding","chromosome;cyclin K-CDK12 complex;cyclin/CDK positive transcription elongation factor complex;fibrillar center;nuclear cyclin-dependent protein kinase holoenzyme complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},18,18,15,"21.7","21.7","18.9","164.15",0,"81.281",624570000,101,"0.256035",1,"1.31477","0.703565","sp|Q9NYV4|CDK12_HUMAN;tr|J3QSD7|J3QSD7_HUMAN;tr|Q9BVE2|Q9BVE2_HUMAN;tr|A0A087X209|A0A087X209_HUMAN;tr|H0YLT2|H0YLT2_HUMAN","sp|Q9NYV4|CDK12_HUMAN;tr|J3QSD7|J3QSD7_HUMAN",4576,"Q9NYV4","CDK12_HUMAN","Cyclin-dependent kinase 12",null,"CDK12"]
["20.2541","20.5109","20.538","17.5988",{"$nulls":3},"androgen metabolic process;bile acid biosynthetic process;bile acid catabolic process;C21-steroid hormone metabolic process;cholesterol catabolic process;digestion;oxidation-reduction process","aldo-keto reductase (NADP) activity;delta4-3-oxosteroid 5beta-reductase activity;steroid binding","cytosol;extracellular exosome","Metabolic pathways;Primary bile acid biosynthesis;Steroid hormone biosynthesis",null,null,3,3,3,"5.5","5.5","5.5","37.376","0.00026254","7.4134",362520000,15,"0.330654",1,"1.31411","0.890793","sp|P51857|AK1D1_HUMAN","sp|P51857|AK1D1_HUMAN",1670,"P51857","AK1D1_HUMAN","3-oxo-5-beta-steroid 4-dehydrogenase",null,"AKR1D1"]
["16.4267","17.7092","16.2163","15.3057",{"$nulls":3},"RNA secondary structure unwinding","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;cytosol;membrane;nucleolus;nucleus",{"$nulls":3},12,12,12,"29.3","29.3","29.3","68.546",0,"137.2",464640000,56,"0.622597",1,"1.30693","1.66174","sp|Q8NHQ9|DDX55_HUMAN;tr|F5H5U2|F5H5U2_HUMAN;tr|E7EX41|E7EX41_HUMAN;tr|F5H2I2|F5H2I2_HUMAN;tr|F5H735|F5H735_HUMAN","sp|Q8NHQ9|DDX55_HUMAN;tr|F5H5U2|F5H5U2_HUMAN;tr|E7EX41|E7EX41_HUMAN",3349,"Q8NHQ9","DDX55_HUMAN","ATP-dependent RNA helicase DDX55",null,"DDX55"]
["18.0461","17.6587","17.5725","15.5284",{"$nulls":9},4,4,4,"8.7","8.7","8.7","73.041",0,"10.435",137520000,6,"0.472018",1,"1.30195","1.25155","tr|F8W9X7|F8W9X7_HUMAN;sp|Q567U6|CCD93_HUMAN;tr|H7C050|H7C050_HUMAN","tr|F8W9X7|F8W9X7_HUMAN;sp|Q567U6|CCD93_HUMAN",2669,"F8W9X7","F8W9X7_HUMAN",null,null,"CCDC93"]
["18.4777","18.791","17.9916","16.697",{"$nulls":3},"bicarbonate transport;platelet degranulation;positive regulation of protein targeting to mitochondrion;sterol biosynthetic process","cytochrome-b5 reductase activity, acting on NAD(P)H;oxidoreductase activity","endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;membrane;mitochondrion;plasma membrane;platelet alpha granule membrane","Amino sugar and nucleotide sugar metabolism",null,null,6,6,6,"22.6","22.6","22.6","34.094",0,"13.161",100280000,18,"0.715935",1,"1.2901","1.93711","sp|Q9UHQ9|NB5R1_HUMAN;tr|H7C0R7|H7C0R7_HUMAN","sp|Q9UHQ9|NB5R1_HUMAN;tr|H7C0R7|H7C0R7_HUMAN",4733,"Q9UHQ9","NB5R1_HUMAN","NADH-cytochrome b5 reductase 1","5R.1","CYB5R1"]
["15.9514","16.1765","15.9943","13.5855",{"$nulls":3},"anastral spindle assembly;astral microtubule organization;cell division;chromosome segregation;establishment of mitotic spindle orientation;meiotic cell cycle;microtubule bundle formation;nucleus organization;positive regulation of BMP signaling pathway;positive regulation of chromosome segregation;positive regulation of chromosome separation;positive regulation of hair follicle development;positive regulation of intracellular transport;positive regulation of keratinocyte differentiation;positive regulation of microtubule polymerization;positive regulation of mitotic spindle elongation;positive regulation of protein localization to cell cortex;positive regulation of protein localization to spindle pole body;positive regulation of spindle assembly;regulation of metaphase plate congression;regulation of mitotic spindle organization","disordered domain specific binding;dynein complex binding;microtubule binding;microtubule minus-end binding;microtubule plus-end binding;phosphatidylinositol binding;protein complex binding;protein C-terminus binding;protein domain specific binding;structural molecule activity;tubulin binding","cell cortex;cell cortex region;centrosome;chromosome;cortical microtubule;cytoplasmic microtubule bundle;cytosol;dendrite;extracellular exosome;extrinsic component of plasma membrane;Golgi membrane;lateral cell cortex;lateral plasma membrane;microtubule bundle;microtubule minus-end;microtubule plus-end;mitotic spindle;mitotic spindle astral microtubule;mitotic spindle midzone;mitotic spindle pole;neuronal cell body;nuclear matrix;nucleoplasm;nucleus;protein complex;spindle;spindle microtubule;spindle pole;spindle pole centrosome",{"$nulls":3},41,41,41,"28.1","28.1","28.1","238.26",0,"226.43",1122200000,147,"0.395033",1,"1.27405","1.05327","sp|Q14980|NUMA1_HUMAN;tr|A0A087WY61|A0A087WY61_HUMAN;tr|H0YFY6|H0YFY6_HUMAN;tr|F5H4J1|F5H4J1_HUMAN;tr|F5H6Y5|F5H6Y5_HUMAN;tr|K4DIE0|K4DIE0_HUMAN;tr|F5H2F3|F5H2F3_HUMAN;tr|F5H3L6|F5H3L6_HUMAN;tr|F5H0Z7|F5H0Z7_HUMAN;tr|F5H763|F5H763_HUMAN;tr|F5GZW1|F5GZW1_HUMAN","sp|Q14980|NUMA1_HUMAN;tr|A0A087WY61|A0A087WY61_HUMAN",2408,"Q14980","NUMA1_HUMAN","Nuclear mitotic apparatus protein 1 {ECO:0000312|HGNC:HGNC:8059}",null,"NUMA1"]
["18.3548","18.3187","18.2988","15.8283",{"$nulls":3},"protein maturation",null,"endoplasmic reticulum membrane;integral component of membrane;membrane",{"$nulls":3},4,4,4,"6.6","6.6","6.6","79.697","0.0002578","7.027",183260000,25,"0.386108",1,"1.27319","1.03061","sp|Q9BU23|LMF2_HUMAN","sp|Q9BU23|LMF2_HUMAN",3977,"Q9BU23","LMF2_HUMAN","Lipase maturation factor 2",null,"LMF2"]
["16.8387","18.069","16.7839","15.5801",{"$nulls":5},"cytoplasm;extracellular region",{"$nulls":3},5,5,5,"12.3","12.3","12.3","56.051","0.00025813","7.0486",37871000,7,"0.556713",1,"1.27189","1.47782","sp|Q6SPF0|SAMD1_HUMAN;tr|E9PIW9|E9PIW9_HUMAN","sp|Q6SPF0|SAMD1_HUMAN;tr|E9PIW9|E9PIW9_HUMAN",2896,"Q6SPF0","SAMD1_HUMAN","Atherin",null,"SAMD1"]
["16.2761","18.3086","16.7593","15.2837",{"$nulls":4},"ATP binding;ATPase activity","mitochondrion",{"$nulls":3},16,16,16,12,12,12,"214.82",0,"44.478",228380000,38,"0.378749",1,"1.27085","1.01196","sp|A3KMH1|VWA8_HUMAN","sp|A3KMH1|VWA8_HUMAN",160,"A3KMH1","VWA8_HUMAN","von Willebrand factor A domain-containing protein 8",null,"VWA8"]
["19.7667","20.1278","19.6669","17.6892",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit",{"$nulls":3},2,2,2,"17.2","17.2","17.2","15.128","0.000668","4.1106",83781000,8,"0.476257",1,"1.2692","1.26265","sp|Q7Z7F7|RM55_HUMAN;tr|X6R631|X6R631_HUMAN;tr|X6RIW1|X6RIW1_HUMAN","sp|Q7Z7F7|RM55_HUMAN;tr|X6R631|X6R631_HUMAN;tr|X6RIW1|X6RIW1_HUMAN",3022,"Q7Z7F7","RM55_HUMAN","39S ribosomal protein L55, mitochondrial","55mt;RP-L55","MRPL55"]
["17.1301","17.7633","15.2275","17.1498",{"$nulls":3},"muscle cell differentiation;negative regulation of T cell proliferation;neural tube closure;positive regulation of cytokine secretion;positive regulation of interleukin-2 biosynthetic process;positive regulation of phosphorylation;regulation of gene expression, epigenetic;regulation of proteasomal ubiquitin-dependent protein catabolic process;vasculogenesis","hepatocyte growth factor receptor binding;ubiquitin protein ligase binding;ubiquitin-protein transferase inhibitor activity","Cul2-RING ubiquitin ligase complex;Cul3-RING ubiquitin ligase complex;Cul4A-RING E3 ubiquitin ligase complex;cullin-RING ubiquitin ligase complex;cytoplasm;intracellular",{"$nulls":3},3,3,3,"6.7","6.7","6.7","68.207",0,"11.757",40974000,5,"0.468824",1,"1.25805","1.2432","sp|Q92990|GLMN_HUMAN;tr|M0QX84|M0QX84_HUMAN;tr|M0QXG8|M0QXG8_HUMAN","sp|Q92990|GLMN_HUMAN",3563,"Q92990","GLMN_HUMAN","Glomulin",null,"GLMN"]
["18.8465","19.4862","18.9266","16.8932",{"$nulls":9},2,2,2,"12.6","12.6","12.6","24.259","0.00068587","4.4964",50407000,6,"0.444051",1,"1.25646","1.17885","tr|C9JJ54|C9JJ54_HUMAN;sp|Q8IWB7|WDFY1_HUMAN","tr|C9JJ54|C9JJ54_HUMAN;sp|Q8IWB7|WDFY1_HUMAN",3124,"C9JJ54","C9JJ54_HUMAN",null,null,"WDFY1"]
["18.7083",1,"16.2041",1,{"$nulls":3},"mRNA processing;RNA splicing","RNA binding","precatalytic spliceosome","Spliceosome",null,null,5,5,5,"11.7","11.7","11.7","64.467",0,"12.619",94504000,19,"0.0341629",1,"1.25207","0.107291","sp|Q5VTL8|PR38B_HUMAN;tr|A0A0A0MRN0|A0A0A0MRN0_HUMAN","sp|Q5VTL8|PR38B_HUMAN;tr|A0A0A0MRN0|A0A0A0MRN0_HUMAN",2756,"Q5VTL8","PR38B_HUMAN","Pre-mRNA-splicing factor 38B",null,"PRPF38B"]
["21.2928",1,"18.7989",1,{"$nulls":3},"acyl-CoA metabolic process;phosphatidylcholine acyl-chain remodeling","benzodiazepine receptor binding;lipid binding;long-chain fatty acyl-CoA binding;protein dimerization activity","endoplasmic reticulum lumen;extracellular exosome;Golgi apparatus;perinuclear endoplasmic reticulum","PPAR signaling pathway",null,null,2,2,2,31,31,31,"10.044","0.00023469","5.0312",55029000,6,"0.029277",1,"1.24692","0.0923902","sp|P07108|ACBP_HUMAN;tr|B8ZWD1|B8ZWD1_HUMAN;tr|A0A0A0MTI5|A0A0A0MTI5_HUMAN","sp|P07108|ACBP_HUMAN;tr|B8ZWD1|B8ZWD1_HUMAN;tr|A0A0A0MTI5|A0A0A0MTI5_HUMAN",889,"P07108","ACBP_HUMAN","Acyl-CoA-binding protein","CBP","DBI"]
["22.2055","23.4348","22.0458","21.102",{"$nulls":4},"calcium ion binding","endoplasmic reticulum;endoplasmic reticulum lumen;nucleolus",{"$nulls":3},10,10,10,"36.9","36.9","36.9","36.876",0,"85.064",823340000,62,"0.603726",1,"1.24624","1.60826","sp|Q14257|RCN2_HUMAN;tr|H0YL43|H0YL43_HUMAN;tr|A8MXP8|A8MXP8_HUMAN","sp|Q14257|RCN2_HUMAN;tr|H0YL43|H0YL43_HUMAN",2353,"Q14257","RCN2_HUMAN","Reticulocalbin-2",null,"RCN2"]
["16.1739","15.5584","14.153","15.0891",{"$nulls":3},"inositol phosphate metabolic process;lipid catabolic process;phosphatidylinositol-mediated signaling","calcium ion binding;calcium-dependent phospholipase C activity;phosphatidylinositol phospholipase C activity;signal transducer activity","cytoplasm;cytosol;intracellular membrane-bounded organelle;plasma membrane","Inositol phosphate metabolism;Metabolic pathways",null,null,11,11,11,"8.3","8.3","8.3","189.22",0,"44.777",208380000,29,"0.806052",1,"1.24511","2.22272","sp|Q4KWH8|PLCH1_HUMAN","sp|Q4KWH8|PLCH1_HUMAN",2634,"Q4KWH8","PLCH1_HUMAN","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1",null,"PLCH1"]
["18.5878","19.4221","17.035","18.4863",{"$nulls":3},"cell cycle;negative regulation of cell proliferation;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of transcription, DNA-templated;positive regulation of histone acetylation;positive regulation of transcription, DNA-templated;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;Wnt signaling pathway","histone binding;lysine-acetylated histone binding;p53 binding;transcription coactivator activity;transcription corepressor activity;transcription factor binding;transcription regulatory region DNA binding","cytoplasm;cytosol;nucleoplasm;nucleus","Hepatocellular carcinoma",null,null,21,21,21,"50.1","50.1","50.1","74.138",0,"323.31",1785600000,136,"0.559907",1,"1.24428","1.48657","sp|Q9NPI1|BRD7_HUMAN;tr|I3L4V5|I3L4V5_HUMAN","sp|Q9NPI1|BRD7_HUMAN",4370,"Q9NPI1","BRD7_HUMAN","Bromodomain-containing protein 7",null,"BRD7"]
["18.5276","16.3233","16.4312","15.9376",{"$nulls":3},"alternative mRNA splicing, via spliceosome;cellular response to heat;intracellular protein transport;mRNA 3'-end processing;mRNA 3'-splice site recognition;mRNA export from nucleus;mRNA splicing, via spliceosome;RNA export from nucleus;RNA splicing, via transesterification reactions;termination of RNA polymerase II transcription","pre-mRNA 3'-splice site binding;second spliceosomal transesterification activity;zinc ion binding","catalytic step 2 spliceosome;cytoplasm;cytosol;intracellular membrane-bounded organelle;membrane;nuclear speck;nucleoplasm;nucleus;small nuclear ribonucleoprotein complex;spliceosomal complex","Spliceosome",null,null,11,11,11,"25.6","25.6","25.6","68.386",0,"76.479",392550000,49,"0.412907",1,"1.24103","1.09882","sp|O95391|SLU7_HUMAN;tr|A0A0C4DGD2|A0A0C4DGD2_HUMAN;tr|E5RGM7|E5RGM7_HUMAN;tr|E5RK41|E5RK41_HUMAN","sp|O95391|SLU7_HUMAN",726,"O95391","SLU7_HUMAN","Pre-mRNA-splicing factor SLU7","Slu7","SLU7"]
["16.0958","15.9456","14.6755","14.885",{"$nulls":3},"animal organ development;apoptotic process;establishment of mitotic spindle orientation;Golgi organization;negative regulation of extrinsic apoptotic signaling pathway;positive regulation of aggrephagy;positive regulation of apoptotic process;positive regulation of autophagy of mitochondrion;positive regulation of cilium assembly;positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;positive regulation of lipophagy;protein destabilization;regulation of phosphoprotein phosphatase activity;retrograde vesicle-mediated transport, Golgi to ER;vesicle transport along microtubule;vocal learning","beta-tubulin binding;dynactin binding;dynein intermediate chain binding;heat shock protein binding;identical protein binding;ion channel binding;kinase binding;lipid transporter activity;p53 binding;profilin binding;transcription factor binding","autophagosome;axon;centriole;cytoplasm;cytoplasmic vesicle membrane;cytosol;dendrite;endoplasmic reticulum;Golgi apparatus;inclusion body;late endosome;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex","Huntington disease",null,null,9,9,9,4,4,4,"347.6",0,"19.931",62838000,12,"1.97356",1,"1.2404","9.62269","sp|P42858|HD_HUMAN","sp|P42858|HD_HUMAN",1482,"P42858","HD_HUMAN","Huntingtin",null,"HTT"]
[1,"16.1846",1,"13.7133",{"$nulls":3},"snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter",null,"transcription elongation factor complex",{"$nulls":3},2,2,2,"4.7","4.7","4.7","53.6","0.00024096","5.5889",31353000,3,"0.0399561",1,"1.23565","0.124788","tr|U3KQ90|U3KQ90_HUMAN;sp|P55199|ELL_HUMAN","tr|U3KQ90|U3KQ90_HUMAN;sp|P55199|ELL_HUMAN",1760,"U3KQ90","U3KQ90_HUMAN",null,null,"ELL"]
["20.4534","19.3036","20.6789","16.6447",{"$nulls":3},"bicellular tight junction assembly;cellular response to insulin stimulus;cortical actin cytoskeleton organization;endocytic recycling;endosomal transport;endothelial cell chemotaxis;establishment of Sertoli cell barrier;neuron projection development;post-translational protein modification;protein kinase A signaling;protein localization to cell leading edge;protein localization to plasma membrane;protein transport;trans-Golgi network to recycling endosome transport","GTP binding;GTPase activity;protein kinase A catalytic subunit binding","bicellular tight junction;cell junction;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;endocytic vesicle;extracellular exosome;insulin-responsive compartment;lamellipodium;lateral plasma membrane;neuron projection;plasma membrane;recycling endosome;recycling endosome membrane;trans-Golgi network","Tight junction",null,null,7,5,4,"39.4","30.5","26.6","22.774",0,"73.494",655470000,50,"0.207255",1,"1.21669","0.580081","sp|P51153|RAB13_HUMAN;tr|A0A087WWB9|A0A087WWB9_HUMAN;tr|M0R257|M0R257_HUMAN;sp|Q96E17|RAB3C_HUMAN","sp|P51153|RAB13_HUMAN",1646,"P51153","RAB13_HUMAN","Ras-related protein Rab-13",null,"RAB13"]
["21.5057","22.0984","20.7002","20.4752",{"$nulls":4},"catalytic activity;magnesium ion binding;thiamine pyrophosphate binding",{"$nulls":4},8,8,8,"29.5","29.5","29.5","56.732",0,"97.368",519660000,35,"1.20843",1,"1.21437","3.83085","tr|M0R026|M0R026_HUMAN;sp|A1L0T0|ILVBL_HUMAN;tr|M0R1B5|M0R1B5_HUMAN;tr|E9PJS0|E9PJS0_HUMAN;tr|M0QZX5|M0QZX5_HUMAN;tr|E9PL44|E9PL44_HUMAN","tr|M0R026|M0R026_HUMAN;sp|A1L0T0|ILVBL_HUMAN",154,"M0R026","M0R026_HUMAN",null,null,"ILVBL"]
["19.7909","19.4176","17.747","19.0437",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;RNA export from nucleus;RNA splicing;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus","RNA binding","nuclear speck;nucleoplasm;THO complex part of transcription export complex;transcription export complex","RNA transport;Spliceosome",null,null,5,5,5,"16.5","16.5","16.5","38.771",0,"21.064",222360000,30,"0.667471",1,"1.20889","1.79177","sp|Q96J01|THOC3_HUMAN;tr|D6RGZ2|D6RGZ2_HUMAN;tr|D6REC9|D6REC9_HUMAN","sp|Q96J01|THOC3_HUMAN;tr|D6RGZ2|D6RGZ2_HUMAN",3739,"Q96J01","THOC3_HUMAN","THO complex subunit 3","ho3","THOC3"]
["18.7134","19.3805","18.6575","17.0223",{"$nulls":3},"abortive mitotic cell cycle;apoptotic process;B cell receptor signaling pathway;cell differentiation;cell proliferation;G-protein coupled receptor signaling pathway;hematopoietic progenitor cell differentiation;intracellular signal transduction;leukocyte migration;megakaryocyte development;natural killer cell mediated cytotoxicity;negative regulation of B cell receptor signaling pathway;negative regulation of cell proliferation;negative regulation of humoral immune response mediated by circulating immunoglobulin;negative regulation of MAP kinase activity;negative regulation of peptidyl-tyrosine phosphorylation;negative regulation of T cell proliferation;negative regulation of T cell receptor signaling pathway;neutrophil degranulation;peptidyl-tyrosine dephosphorylation;peptidyl-tyrosine phosphorylation;platelet activation;platelet aggregation;platelet formation;positive regulation of cell adhesion mediated by integrin;positive regulation of cell proliferation;positive regulation of phosphatidylinositol 3-kinase signaling;protein dephosphorylation;regulation of B cell differentiation;regulation of ERK1 and ERK2 cascade;regulation of G1/S transition of mitotic cell cycle;regulation of release of sequestered calcium ion into cytosol;regulation of type I interferon-mediated signaling pathway;T cell costimulation","cell adhesion molecule binding;phosphotyrosine residue binding;protein kinase binding;protein tyrosine phosphatase activity;SH2 domain binding;SH3 domain binding;transmembrane receptor protein tyrosine phosphatase activity","alpha-beta T cell receptor complex;cell-cell junction;cytoplasm;cytosol;extracellular exosome;extracellular region;membrane;nucleolus;nucleus;protein complex;specific granule lumen;tertiary granule lumen","Adherens junction;B cell receptor signaling pathway;Jak-STAT signaling pathway;Leishmaniasis;Natural killer cell mediated cytotoxicity;PD-L1 expression and PD-1 checkpoint pathway in cancer;Proteoglycans in cancer;T cell receptor signaling pathway",null,null,10,10,10,"20.7","20.7","20.7","67.56",0,"34.488",278240000,44,"0.515701",1,"1.2071","1.36699","sp|P29350|PTN6_HUMAN;tr|F5H0N8|F5H0N8_HUMAN;tr|F5H5H9|F5H5H9_HUMAN;tr|F5GY79|F5GY79_HUMAN;tr|F5H1Z8|F5H1Z8_HUMAN;tr|F5H1V7|F5H1V7_HUMAN;tr|F5H4Z1|F5H4Z1_HUMAN;tr|F5GXD4|F5GXD4_HUMAN;tr|U3KQS1|U3KQS1_HUMAN","sp|P29350|PTN6_HUMAN",1282,"P29350","PTN6_HUMAN","Tyrosine-protein phosphatase non-receptor type 6",null,"PTPN6"]
["20.4828","21.2769","20.8036","18.5497",{"$nulls":3},"post-translational protein modification","prenylated protein tyrosine phosphatase activity","cytoplasm;cytosol;early endosome;extracellular exosome;nucleus;plasma membrane",{"$nulls":3},4,4,4,"35.9","35.9","35.9","19.127",0,"8.5117",141690000,13,"0.376754",1,"1.20314","1.00692","sp|Q12974|TP4A2_HUMAN;tr|E9PMY3|E9PMY3_HUMAN;tr|E9PML8|E9PML8_HUMAN;tr|E9PJC0|E9PJC0_HUMAN;tr|E9PRR9|E9PRR9_HUMAN;sp|Q93096|TP4A1_HUMAN;tr|A0A0D9SGK2|A0A0D9SGK2_HUMAN","sp|Q12974|TP4A2_HUMAN;tr|E9PMY3|E9PMY3_HUMAN;tr|E9PML8|E9PML8_HUMAN;tr|E9PJC0|E9PJC0_HUMAN;tr|E9PRR9|E9PRR9_HUMAN;sp|Q93096|TP4A1_HUMAN",2188,"Q12974","TP4A2_HUMAN","Protein tyrosine phosphatase type IVA 2",null,"PTP4A2"]
["18.8574","17.3884","18.104","15.7415",{"$nulls":3},"cell differentiation;DNA dealkylation involved in DNA repair;mRNA export from nucleus;mRNA processing;oxidative single-stranded RNA demethylation;response to hypoxia;spermatogenesis","metal ion binding;oxidative RNA demethylase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;RNA binding","cytosol;Golgi apparatus;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"11.9","11.9","11.9","44.255","0.00025595","6.8942",41498000,8,"0.319502",1,"1.20016","0.86281","sp|Q6P6C2|ALKB5_HUMAN;tr|K7ER58|K7ER58_HUMAN","sp|Q6P6C2|ALKB5_HUMAN",2873,"Q6P6C2","ALKB5_HUMAN","RNA demethylase ALKBH5 {ECO:0000303|PubMed:24616105}",null,"ALKBH5"]
["18.1927","18.0154","17.1291","16.6809",{"$nulls":3},"NAD biosynthesis via nicotinamide riboside salvage pathway","ADP-dependent NAD(P)H-hydrate dehydratase activity;ATP binding;ATP-dependent NAD(P)H-hydrate dehydratase activity","mitochondrial matrix",{"$nulls":3},2,2,2,"10.4","10.4","10.4","36.576","0.00087873","3.9219",33460000,3,"1.41904",1,"1.19908","4.97537","sp|Q8IW45|NNRD_HUMAN","sp|Q8IW45|NNRD_HUMAN",3121,"Q8IW45","NNRD_HUMAN","ATP-dependent (S)-NAD(P)H-hydrate dehydratase {ECO:0000255|HAMAP-Rule:MF_03157}",null,"NAXD"]
[1,"16.8437",1,"14.4556",{"$nulls":3},"muscle organ development;positive regulation of histone methylation;positive regulation of myoblast proliferation;positive regulation of transcription from RNA polymerase II promoter;regulation of skeletal muscle satellite cell proliferation;transcription, DNA-templated","DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcription factor binding","cytosol;nucleus",{"$nulls":3},7,7,7,"10.5","10.5","10.5","104.8",0,"22.137",122730000,25,"0.0366703",1,"1.19403","0.114886","sp|Q9Y5B6|PAXB1_HUMAN","sp|Q9Y5B6|PAXB1_HUMAN",5037,"Q9Y5B6","PAXB1_HUMAN","PAX3- and PAX7-binding protein 1",null,"PAXBP1"]
["16.6813","17.7355","17.1579","14.9083",{"$nulls":3},"endocytosis;intracellular protein transport",null,"AP-1 adaptor complex;cytoplasm;Golgi apparatus",{"$nulls":3},6,6,6,"7.3","7.3","7.3","140.65",0,"16.965",87414000,20,"0.352675",1,"1.17527","0.946152","sp|Q9UMZ2|SYNRG_HUMAN;tr|A0A087WZS7|A0A087WZS7_HUMAN","sp|Q9UMZ2|SYNRG_HUMAN",4836,"Q9UMZ2","SYNRG_HUMAN","Synergin gamma",null,"SYNRG"]
["16.0114","17.542","14.8382","16.3676",{"$nulls":3},"beta-catenin-TCF complex assembly;DNA repair;histone acetylation;histone deubiquitination;histone H2A acetylation;histone H4 acetylation;protein deubiquitination;regulation of transcription, DNA-templated;transcription, DNA-templated","kinase activity;thiol-dependent ubiquitinyl hydrolase activity;transcription cofactor activity","Golgi apparatus;NuA4 histone acetyltransferase complex;nucleoplasm;nucleus;PCAF complex;STAGA complex;Swr1 complex;transcription factor TFTC complex","Human T-cell leukemia virus 1 infection",null,null,55,55,0,"18.6","18.6",0,"437.6",0,"204.32",1192300000,137,"0.40749",1,"1.17383","1.08499","sp|Q9Y4A5|TRRAP_HUMAN;tr|C9K0N1|C9K0N1_HUMAN","sp|Q9Y4A5|TRRAP_HUMAN",5009,"Q9Y4A5","TRRAP_HUMAN","Transformation/transcription domain-associated protein",null,"TRRAP"]
["18.9276","19.4122","17.7961","18.2259",{"$nulls":3},"maturation of SSU-rRNA;positive regulation of rRNA processing;ribosomal small subunit biogenesis;rRNA processing","ATP binding;hydrolase activity;metal ion binding;protein serine/threonine kinase activity","cytosol;nucleoplasm;preribosome, small subunit precursor","Ribosome biogenesis in eukaryotes",null,null,17,17,17,"35.9","35.9","35.9","65.582",0,"184.28",1820500000,128,"1.15493",1,"1.15887","3.57838","sp|Q9BRS2|RIOK1_HUMAN;tr|E9PFQ8|E9PFQ8_HUMAN","sp|Q9BRS2|RIOK1_HUMAN",3939,"Q9BRS2","RIOK1_HUMAN","Serine/threonine-protein kinase RIO1",null,"RIOK1"]
["18.3648","16.4517","18.4188","14.0824",{"$nulls":3},"meiotic cell cycle;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;transcription, DNA-templated","nucleic acid binding;protein homodimerization activity;zinc ion binding","cytosol;nucleoplasm",{"$nulls":3},16,16,16,"7.8","7.8","7.8","251.11",0,"20.649",321150000,34,"0.171653",1,"1.15764","0.488489","sp|Q5VUA4|ZN318_HUMAN","sp|Q5VUA4|ZN318_HUMAN",2758,"Q5VUA4","ZN318_HUMAN","Zinc finger protein 318",null,"ZNF318"]
["19.4375","19.1083","19.3665","16.8776",{"$nulls":5},"cytosol;Golgi apparatus;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"21.7","21.7","21.7","60.741",0,"13.71",76764000,13,"0.341008",1,"1.15086","0.916802","sp|Q8IWE2|NXP20_HUMAN","sp|Q8IWE2|NXP20_HUMAN",3127,"Q8IWE2","NXP20_HUMAN","Protein NOXP20",null,"FAM114A1"]
["19.1945","18.0223","16.1134","18.8035",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;cargo loading into COPII-coated vesicle;COPII vesicle coating;ER to Golgi vesicle-mediated transport;intracellular protein transport;positive regulation of cholesterol homeostasis;positive regulation of protein secretion;regulation of low-density lipoprotein particle receptor biosynthetic process","zinc ion binding","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane","Protein processing in endoplasmic reticulum",null,null,7,6,6,"7.9","7.1","7.1","119.75",0,"16.701",135460000,26,"0.287967",1,"1.14993","0.783748","sp|O95486|SC24A_HUMAN;tr|H0Y9J6|H0Y9J6_HUMAN","sp|O95486|SC24A_HUMAN",738,"O95486","SC24A_HUMAN","Protein transport protein Sec24A {ECO:0000305}",null,"SEC24A"]
["22.0318","20.5453","21.9839","18.2936",{"$nulls":3},"cilium assembly;intraciliary transport;kidney development;mitotic cytokinesis;photoreceptor cell development;post-Golgi vesicle-mediated transport;small GTPase mediated signal transduction;smoothened signaling pathway","GDP binding;GTP binding;GTPase activity;metal ion binding;microtubule binding","centrosome;cilium;cytoplasmic microtubule;extracellular exosome;Golgi apparatus;Golgi membrane;midbody;nucleus;photoreceptor connecting cilium;spindle microtubule",{"$nulls":3},7,7,7,"48.4","48.4","48.4","20.455",0,"23.11",323760000,17,"0.206444",1,"1.1498","0.578013","sp|P36405|ARL3_HUMAN","sp|P36405|ARL3_HUMAN",1403,"P36405","ARL3_HUMAN","ADP-ribosylation factor-like protein 3",null,"ARL3"]
["17.7429","18.0295","18.1189","15.3556",{"$nulls":4},"zinc ion binding","nucleus",{"$nulls":3},3,3,3,"10.5","10.5","10.5","50.562",0,"12.126",55643000,15,"0.305279",1,"1.14895","0.827147","tr|C9J0I9|C9J0I9_HUMAN;sp|Q86WB0|NIPA_HUMAN;tr|F8WAU5|F8WAU5_HUMAN","tr|C9J0I9|C9J0I9_HUMAN;sp|Q86WB0|NIPA_HUMAN",3070,"C9J0I9","C9J0I9_HUMAN",null,null,"ZC3HC1"]
["19.0831","19.1634","19.0025","16.9473",{"$nulls":3},"tRNA methylation","RNA binding;tRNA (guanine(9)-N(1))-methyltransferase activity;tRNA (guanine-N1-)-methyltransferase activity;tRNA binding","actin cytoskeleton;cytosol;extracellular exosome;nucleolus;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"15.3","15.3","15.3","39.718",0,"9.7353",80784000,12,"0.419872",1,"1.14833","1.11664","sp|Q8TBZ6|TM10A_HUMAN;tr|D6R954|D6R954_HUMAN;tr|X6REK4|X6REK4_HUMAN","sp|Q8TBZ6|TM10A_HUMAN;tr|D6R954|D6R954_HUMAN;tr|X6REK4|X6REK4_HUMAN",3371,"Q8TBZ6","TM10A_HUMAN","tRNA methyltransferase 10 homolog A",null,"TRMT10A"]
["16.0111","15.6695","15.5397","13.8518",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular response to UV;embryonic digit morphogenesis;histone acetylation;homeostatic process;negative regulation of transcription from RNA polymerase II promoter;Notch signaling pathway;N-terminal peptidyl-lysine acetylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;protein acetylation;protein complex assembly;protein destabilization;regulation of apoptotic process;regulation of cellular response to heat;regulation of lipid metabolic process;regulation of myeloid cell differentiation;regulation of smoothened signaling pathway;regulation of transcription from RNA polymerase II promoter in response to hypoxia;regulation of transcription, DNA-templated;response to hypoxia;rhythmic process;signal transduction;stimulatory C-type lectin receptor signaling pathway;transcription initiation from RNA polymerase II promoter;viral process","acetyltransferase activity;chromatin binding;damaged DNA binding;DNA binding transcription factor activity;histone acetyltransferase activity;MRF binding;p53 binding;peptide N-acetyltransferase activity;proximal promoter sequence-specific DNA binding;RNA polymerase II activating transcription factor binding;RNA polymerase II transcription coactivator activity;RNA polymerase II transcription factor binding;signal transducer activity;transcription coactivator activity;transcription factor binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription factor binding;zinc ion binding","cytoplasm;histone acetyltransferase complex;nuclear body;nuclear chromatin;nucleoplasm;nucleus","Adherens junction;cAMP signaling pathway;Cell cycle;FoxO signaling pathway;Glucagon signaling pathway;Hepatitis B;HIF-1 signaling pathway;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term potentiation;Melanogenesis;MicroRNAs in cancer;Notch signaling pathway;Pathways in cancer;Prostate cancer;Renal cell carcinoma;TGF-beta signaling pathway;Thyroid hormone signaling pathway;Tuberculosis;Viral carcinogenesis;Wnt signaling pathway",null,null,9,4,4,"6.6","3.2","3.2","265.35",0,"12.197",45043000,13,"0.501532",1,"1.14455","1.32927","sp|Q92793|CBP_HUMAN;tr|I3L466|I3L466_HUMAN","sp|Q92793|CBP_HUMAN",3530,"Q92793","CBP_HUMAN","CREB-binding protein",null,"CREBBP"]
["24.82","25.5632","24.9837","23.1144",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},7,7,7,"35.1","35.1","35.1","22.389",0,"52.807",4640700000,140,"0.427395",1,"1.14251","1.13594","tr|E9PKZ0|E9PKZ0_HUMAN;sp|P62917|RL8_HUMAN;tr|G3V1A1|G3V1A1_HUMAN;tr|E9PKU4|E9PKU4_HUMAN;tr|E9PP36|E9PP36_HUMAN","tr|E9PKZ0|E9PKZ0_HUMAN;sp|P62917|RL8_HUMAN;tr|G3V1A1|G3V1A1_HUMAN;tr|E9PKU4|E9PKU4_HUMAN",1928,"E9PKZ0","E9PKZ0_HUMAN",null,null,"RPL8"]
["15.9855","19.0673","17.0253","15.7537",{"$nulls":3},"calcium ion transport into cytosol;muscle organ development;regulation of ryanodine-sensitive calcium-release channel activity","structural constituent of muscle","integral component of membrane;junctional membrane complex;junctional sarcoplasmic reticulum membrane;plasma membrane;Z disc",{"$nulls":3},13,13,13,28,28,28,"71.685",0,"62.978",1393500000,101,"0.247489",1,"1.13692","0.682044","sp|Q9HDC5|JPH1_HUMAN","sp|Q9HDC5|JPH1_HUMAN",4346,"Q9HDC5","JPH1_HUMAN","Junctophilin-1","P-1","JPH1"]
["16.3984","14.9732","16.7046","12.3975",{"$nulls":3},"histone methylation;regulation of transcription, DNA-templated;transcription, DNA-templated","histone-lysine N-methyltransferase activity;metal ion binding","chromosome;nucleoplasm;nucleus","Lysine degradation",null,null,16,16,16,14,14,14,"161.61",0,"65.601",644780000,87,"0.176192",1,"1.13478","0.50026","sp|Q9BZ95|NSD3_HUMAN;tr|E9PKA2|E9PKA2_HUMAN;tr|H0YE68|H0YE68_HUMAN","sp|Q9BZ95|NSD3_HUMAN",4071,"Q9BZ95","NSD3_HUMAN","Histone-lysine N-methyltransferase NSD3",null,"NSD3"]
["16.0481","18.7795","16.6505","15.9206",{"$nulls":3},"positive regulation of gene expression, epigenetic;RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript;rRNA transcription;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription initiation from RNA polymerase I promoter","DNA binding;DNA-directed 5'-3' RNA polymerase activity;RNA polymerase I transcription factor binding","DNA-directed RNA polymerase I complex;fibrillar center;nucleolus;nucleoplasm;nucleus","RNA polymerase",null,null,14,14,8,"28.5","28.5","19.1","53.961",0,"53.447",699460000,90,"0.293707",1,"1.12828","0.798139","sp|Q9GZS1|RPA49_HUMAN","sp|Q9GZS1|RPA49_HUMAN",4114,"Q9GZS1","RPA49_HUMAN","DNA-directed RNA polymerase I subunit RPA49","NA polymerase I subunit A49","POLR1E"]
["21.335","21.3739","19.9419","20.5147",{"$nulls":3},"vacuolar transport",null,"cytosol",{"$nulls":3},2,2,2,"10.9","10.9","10.9","20.772",0,"10.234",106040000,8,"1.22726",1,"1.12614","3.92313","tr|C9J0A7|C9J0A7_HUMAN;sp|Q9UQN3|CHM2B_HUMAN;tr|A0A087WW88|A0A087WW88_HUMAN","tr|C9J0A7|C9J0A7_HUMAN;sp|Q9UQN3|CHM2B_HUMAN;tr|A0A087WW88|A0A087WW88_HUMAN",4885,"C9J0A7","C9J0A7_HUMAN",null,null,"CHMP2B"]
["21.6282","22.1701","21.8001","19.7494",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;cargo loading into COPII-coated vesicle;COPII vesicle coating;intracellular protein transport;mRNA transport;positive regulation of TOR signaling;sister chromatid cohesion","identical protein binding;structural molecule activity","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;extracellular exosome;GATOR2 complex;Golgi membrane;intracellular membrane-bounded organelle;lysosomal membrane;nuclear envelope;nuclear pore outer ring;nucleoplasm","mTOR signaling pathway;Protein processing in endoplasmic reticulum;RNA transport",null,null,6,6,6,"32.6","32.6","32.6","35.54",0,"67.956",366660000,28,"0.397747",1,"1.12439","1.06017","sp|P55735|SEC13_HUMAN;tr|A0A0C4DFR6|A0A0C4DFR6_HUMAN;tr|A8MXL6|A8MXL6_HUMAN;tr|E7ERC8|E7ERC8_HUMAN","sp|P55735|SEC13_HUMAN;tr|A0A0C4DFR6|A0A0C4DFR6_HUMAN;tr|A8MXL6|A8MXL6_HUMAN",1767,"P55735","SEC13_HUMAN","Protein SEC13 homolog {ECO:0000305}",null,"SEC13"]
["18.3798","19.4687","19.4469","16.1586",{"$nulls":3},"cellular protein complex assembly;cellular response to misfolded protein;chaperone cofactor-dependent protein refolding;chaperone mediated protein folding requiring cofactor;ERAD pathway","Hsp70 protein binding","endoplasmic reticulum;integral component of endoplasmic reticulum membrane;membrane;nuclear membrane","Protein processing in endoplasmic reticulum",null,null,9,9,9,"27.5","27.5","27.5","41.818",0,"43.443",332180000,50,"0.233817",1,"1.1215","0.64753","sp|Q9NXW2|DJB12_HUMAN;tr|J3KPS0|J3KPS0_HUMAN;tr|V9GYN7|V9GYN7_HUMAN;tr|V9GY70|V9GY70_HUMAN","sp|Q9NXW2|DJB12_HUMAN;tr|J3KPS0|J3KPS0_HUMAN;tr|V9GYN7|V9GYN7_HUMAN",4555,"Q9NXW2","DJB12_HUMAN","DnaJ homolog subfamily B member 12 {ECO:0000312|HGNC:HGNC:14891}",null,"DNAJB12"]
["20.0344","21.508","20.8412","18.4612",{"$nulls":3},"activation of MAPK activity;ERK1 and ERK2 cascade;MAPK cascade;negative regulation of gene expression;peptidyl-serine autophosphorylation;positive regulation of ERK1 and ERK2 cascade;positive regulation of production of miRNAs involved in gene silencing by miRNA;positive regulation of protein serine/threonine kinase activity;positive regulation of transcription, DNA-templated;proteolysis in other organism;regulation of apoptotic process;regulation of early endosome to late endosome transport;regulation of Golgi inheritance;regulation of mitotic cell cycle;regulation of stress-activated MAPK cascade","ATP binding;MAP kinase kinase activity;metal ion binding;PDZ domain binding;protein serine/threonine kinase activator activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity;scaffold protein binding","cell-cell junction;cytoplasmic side of plasma membrane;cytosol;early endosome;endoplasmic reticulum;extracellular region;focal adhesion;Golgi apparatus;late endosome;microtubule;mitochondrion;nucleus;perinuclear region of cytoplasm;peroxisomal membrane;plasma membrane","Acute myeloid leukemia;Apelin signaling pathway;Apoptosis;Autophagy - animal;B cell receptor signaling pathway;Bladder cancer;Breast cancer;cAMP signaling pathway;Cellular senescence;Central carbon metabolism in cancer;cGMP-PKG signaling pathway;Choline metabolism in cancer;Chronic myeloid leukemia;Colorectal cancer;Cushing syndrome;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;MicroRNAs in cancer;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-small cell lung cancer;Oxytocin signaling pathway;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prion diseases;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid cancer;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Yersinia infection",null,null,10,7,7,"33.8","23.8","23.8","44.424",0,"43.34",274530000,27,"0.29453",1,"1.11998","0.800202","sp|P36507|MP2K2_HUMAN;tr|G5E9C7|G5E9C7_HUMAN;tr|M0R1B6|M0R1B6_HUMAN","sp|P36507|MP2K2_HUMAN;tr|G5E9C7|G5E9C7_HUMAN",1405,"P36507","MP2K2_HUMAN","Dual specificity mitogen-activated protein kinase kinase 2","AP kinase kinase 2;APKK 2","MAP2K2"]
["16.6865","20.1311","16.8675","17.7121",{"$nulls":4},"actin binding;ATP binding;calmodulin binding;motor activity","extracellular exosome;myosin complex",{"$nulls":3},29,26,25,"17.9","16.1","15.4","202.81",0,"81.151",645770000,57,"0.227289",1,"1.11897","0.631007","sp|Q9NQX4|MYO5C_HUMAN;tr|H0YMK3|H0YMK3_HUMAN;tr|H0YM93|H0YM93_HUMAN;tr|H0YM96|H0YM96_HUMAN","sp|Q9NQX4|MYO5C_HUMAN",4400,"Q9NQX4","MYO5C_HUMAN","Unconventional myosin-Vc",null,"MYO5C"]
["17.685","17.706","17.4859","15.6798",{"$nulls":3},"intracellular protein transport;response to brefeldin A",null,"cytoplasm;cytoplasmic microtubule;cytosol;extracellular exosome;extrinsic component of Golgi membrane;Golgi apparatus;Golgi medial cisterna;Golgi trans cisterna",{"$nulls":3},3,3,3,"7.9","7.9","7.9","88.743","0.00066342","4.0223",93376000,9,"0.464542",1,"1.11267","1.23203","sp|Q8IV36|HID1_HUMAN;tr|E9PIM7|E9PIM7_HUMAN","sp|Q8IV36|HID1_HUMAN",3109,"Q8IV36","HID1_HUMAN","Protein HID1",null,"HID1"]
["13.5996","16.5107","13.3727","14.5249",{"$nulls":3},"histone H2A acetylation;histone H4 acetylation","ATP binding;chromatin binding;DNA binding;helicase activity;protein antigen binding","NuA4 histone acetyltransferase complex;nuclear speck;nucleoplasm;Swr1 complex",{"$nulls":3},14,14,14,"6.6","6.6","6.6","343.48",0,"32.097",196100000,51,"0.257286",1,"1.10629","0.706712","sp|Q96L91|EP400_HUMAN;tr|A0A0A0MR70|A0A0A0MR70_HUMAN;tr|A0A0A0MR80|A0A0A0MR80_HUMAN","sp|Q96L91|EP400_HUMAN",3763,"Q96L91","EP400_HUMAN","E1A-binding protein p400",null,"EP400"]
["17.2437","17.5578","16.1696","16.4206",{"$nulls":3},"adherens junction organization;axonogenesis;lateral ventricle development;negative regulation of protein localization to plasma membrane;neuroblast division in subventricular zone;positive regulation of cell migration;positive regulation of neurogenesis","alpha-catenin binding;beta-catenin binding;cadherin binding","apical part of cell;basolateral plasma membrane;clathrin-coated vesicle;early endosome;extrinsic component of plasma membrane;focal adhesion;nucleus;plasma membrane","Notch signaling pathway",null,null,17,17,17,"47.6","47.6","47.6","70.803",0,"70.864",555160000,85,"1.50167",1,"1.10564","5.50024","sp|P49757|NUMB_HUMAN;tr|G3V3Z8|G3V3Z8_HUMAN;tr|G3V3R1|G3V3R1_HUMAN;tr|G3V3M5|G3V3M5_HUMAN;tr|G3V4S6|G3V4S6_HUMAN;tr|G3V433|G3V433_HUMAN","sp|P49757|NUMB_HUMAN;tr|G3V3Z8|G3V3Z8_HUMAN",1597,"P49757","NUMB_HUMAN","Protein numb homolog",{"$f":"-Numb","v":{"$error":"#NAME?"}},"NUMB"]
["20.1345","18.0486","19.6537","16.323",{"$nulls":3},"cell differentiation;multicellular organism development;negative regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;histone acetyltransferase binding;metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nucleus",{"$nulls":3},7,7,7,"30.7","30.7","30.7","61.438",0,"57.168",472490000,40,"0.199959",1,"1.10319","0.561439","sp|O95365|ZBT7A_HUMAN","sp|O95365|ZBT7A_HUMAN",722,"O95365","ZBT7A_HUMAN","Zinc finger and BTB domain-containing protein 7A",null,"ZBTB7A"]
[1,"14.3584",1,"12.1584",{"$nulls":3},"RNA processing;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;nucleolus;nucleoplasm",{"$nulls":3},7,7,7,"7.3","7.3","7.3","129.54",0,"18.075",106060000,20,"0.0404924",1,"1.10003","0.126399","sp|Q8IY37|DHX37_HUMAN;tr|F5H3Y4|F5H3Y4_HUMAN","sp|Q8IY37|DHX37_HUMAN;tr|F5H3Y4|F5H3Y4_HUMAN",3158,"Q8IY37","DHX37_HUMAN","Probable ATP-dependent RNA helicase DHX37",null,"DHX37"]
["15.4153","15.8639","15.342","13.7375",{"$nulls":3},"brain development;intracellular signal transduction;lipid catabolic process;regulation of cell cycle","calcium ion binding;phosphatidylinositol phospholipase C activity;signal transducer activity","cytoplasm;nucleus",{"$nulls":3},4,4,4,"5.3","5.3","5.3","109.06","0.00026817","7.8934",52158000,17,"0.498135",1,"1.09985","1.32027","tr|A0A0D9SF51|A0A0D9SF51_HUMAN;tr|A0A0D9SG17|A0A0D9SG17_HUMAN;tr|A0A087WW73|A0A087WW73_HUMAN;tr|A0A087WT80|A0A087WT80_HUMAN;sp|Q9NQ66|PLCB1_HUMAN;tr|H0YCJ2|H0YCJ2_HUMAN;tr|A0A0D9SFJ4|A0A0D9SFJ4_HUMAN;tr|A0A0D9SGI7|A0A0D9SGI7_HUMAN","tr|A0A0D9SF51|A0A0D9SF51_HUMAN;tr|A0A0D9SG17|A0A0D9SG17_HUMAN;tr|A0A087WW73|A0A087WW73_HUMAN;tr|A0A087WT80|A0A087WT80_HUMAN;sp|Q9NQ66|PLCB1_HUMAN;tr|H0YCJ2|H0YCJ2_HUMAN",4381,"A0A0D9SF51","A0A0D9SF51_HUMAN","Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133}",null,"PLCB1"]
["16.8554","18.663","14.2837","19.0364",{"$nulls":3},"tRNA splicing, via endonucleolytic cleavage and ligation","transferase activity, transferring phosphorus-containing groups",{"$nulls":4},2,2,2,"16.8","16.8","16.8","20.615","0.00067781","4.3029",59383000,11,"0.150179",1,"1.09916","0.432326","tr|F5H8A0|F5H8A0_HUMAN;sp|Q86TN4|TRPT1_HUMAN;tr|F5H6B6|F5H6B6_HUMAN","tr|F5H8A0|F5H8A0_HUMAN;sp|Q86TN4|TRPT1_HUMAN;tr|F5H6B6|F5H6B6_HUMAN",3036,"F5H8A0","F5H8A0_HUMAN",null,null,"TRPT1"]
["20.5237","18.6661","21.2638","15.7295",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","small ribosomal subunit rRNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;small ribosomal subunit","Ribosome",null,null,6,6,6,"58.4","58.4","58.4","14.226",0,"11.124",82335000,11,"0.129076",1,"1.09824","0.376258","sp|P82932|RT06_HUMAN","sp|P82932|RT06_HUMAN",1998,"P82932","RT06_HUMAN","28S ribosomal protein S6, mitochondrial","6mt;RP-S6","MRPS6"]
["20.4061","18.8548","20.168","16.8982",{"$nulls":3},"positive regulation of NF-kappaB transcription factor activity","DNA binding;DNA binding transcription factor activity","cytosol;NF-kappaB complex;nucleus",{"$nulls":3},7,7,7,"28.6","28.6","28.6","42.868",0,"18.454",175370000,15,"0.217592",1,"1.09735","0.606403","tr|Q2TAM5|Q2TAM5_HUMAN;tr|A0A087X0W8|A0A087X0W8_HUMAN;sp|Q04206|TF65_HUMAN;tr|E9PKV4|E9PKV4_HUMAN;tr|A0A087WVP0|A0A087WVP0_HUMAN;tr|E9PKH5|E9PKH5_HUMAN;tr|E9PMD5|E9PMD5_HUMAN;tr|E9PI38|E9PI38_HUMAN;tr|E9PQS6|E9PQS6_HUMAN;tr|E9PNV4|E9PNV4_HUMAN;tr|E9PJR1|E9PJR1_HUMAN;tr|E9PRX2|E9PRX2_HUMAN;tr|E9PM47|E9PM47_HUMAN;tr|E9PNK5|E9PNK5_HUMAN;tr|E9PN69|E9PN69_HUMAN;tr|E9PJZ9|E9PJZ9_HUMAN","tr|Q2TAM5|Q2TAM5_HUMAN;tr|A0A087X0W8|A0A087X0W8_HUMAN;sp|Q04206|TF65_HUMAN;tr|E9PKV4|E9PKV4_HUMAN;tr|A0A087WVP0|A0A087WVP0_HUMAN;tr|E9PKH5|E9PKH5_HUMAN;tr|E9PMD5|E9PMD5_HUMAN;tr|E9PI38|E9PI38_HUMAN;tr|E9PQS6|E9PQS6_HUMAN;tr|E9PNV4|E9PNV4_HUMAN",2087,"Q2TAM5","Q2TAM5_HUMAN"]
["16.0025","17.9416","14.6167","17.1401",{"$nulls":3},"glycosaminoglycan biosynthetic process;O-glycan processing","carbohydrate binding;metal ion binding;polypeptide N-acetylgalactosaminyltransferase activity","Golgi membrane;integral component of membrane","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,6,6,6,"7.8","7.8","7.8","106.26",0,"22.51",181600000,28,"0.249584",1,"1.09366","0.687323","sp|Q7Z7M9|GALT5_HUMAN","sp|Q7Z7M9|GALT5_HUMAN",3025,"Q7Z7M9","GALT5_HUMAN","Polypeptide N-acetylgalactosaminyltransferase 5",null,"GALNT5"]
["19.0377","19.1815","19.3448","16.6979",{"$nulls":3},"cytoplasmic mRNA processing body assembly;deadenylation-independent decapping of nuclear-transcribed mRNA;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay","identical protein binding;mRNA binding;phosphodiesterase decapping endonuclease activity","cytoplasmic ribonucleoprotein granule;cytosol;membrane;P-body","RNA degradation",null,null,6,6,6,13,13,13,"56.077",0,"15.115",106370000,23,"0.302858",1,"1.08825","0.821079","sp|Q96F86|EDC3_HUMAN;tr|H3BSQ0|H3BSQ0_HUMAN;tr|H3BPN4|H3BPN4_HUMAN;tr|H3BPW9|H3BPW9_HUMAN","sp|Q96F86|EDC3_HUMAN;tr|H3BSQ0|H3BSQ0_HUMAN;tr|H3BPN4|H3BPN4_HUMAN",3682,"Q96F86","EDC3_HUMAN","Enhancer of mRNA-decapping protein 3",null,"EDC3"]
["15.2502","16.7028","14.2323","15.5586",{"$nulls":3},"anatomical structure morphogenesis;atrial septum primum morphogenesis;atrial septum secundum morphogenesis;bone development;double-strand break repair via nonhomologous end joining;histone H3-K36 methylation;membranous septum morphogenesis;negative regulation of transcription from RNA polymerase II promoter;positive regulation of isotype switching to IgA isotypes;regulation of double-strand break repair via nonhomologous end joining;regulation of establishment of protein localization;transcription, DNA-templated","chromatin binding;histone methyltransferase activity (H4-K20 specific);histone-lysine N-methyltransferase activity;metal ion binding;sequence-specific DNA binding","chromosome;cytoplasm;nucleoplasm;nucleus","Lysine degradation;Transcriptional misregulation in cancer",null,null,11,11,11,"11.4","11.4","11.4","152.26",0,"29.832",168340000,32,"0.413068",1,"1.08109","1.09923","sp|O96028|NSD2_HUMAN;tr|D6R9V2|D6R9V2_HUMAN;tr|H0Y9L4|H0Y9L4_HUMAN;tr|D6RIS1|D6RIS1_HUMAN;tr|H0Y9U6|H0Y9U6_HUMAN","sp|O96028|NSD2_HUMAN;tr|D6R9V2|D6R9V2_HUMAN",792,"O96028","NSD2_HUMAN","Histone-lysine N-methyltransferase NSD2",null,"NSD2"]
["21.5464","21.0156","19.889","20.5224",{"$nulls":3},"cellular response to insulin stimulus;liver regeneration;mRNA 3'-end processing;mRNA export from nucleus;mRNA processing;mRNA splice site selection;mRNA splicing, via spliceosome;positive regulation of RNA splicing;regulation of cell cycle;RNA export from nucleus;termination of RNA polymerase II transcription","protein kinase B binding;RNA binding","cytosol;nuclear speck;nucleolus;nucleoplasm;nucleus","Herpes simplex virus 1 infection;Spliceosome",null,null,3,2,2,14,"10.7","10.7","31.263",0,"12.359",180460000,13,"0.915971",1,"1.07531","2.60252","sp|Q13243|SRSF5_HUMAN","sp|Q13243|SRSF5_HUMAN",2226,"Q13243","SRSF5_HUMAN","Serine/arginine-rich splicing factor 5",null,"SRSF5"]
["17.4107","19.079","14.7998","19.5424",{"$nulls":5},"nucleus",{"$nulls":3},8,8,8,"22.8","22.8","22.8","42.612",0,"34.008",452970000,47,"0.148217",1,"1.07375","0.427155","tr|S5FZ81|S5FZ81_HUMAN;sp|Q8WUB8|PHF10_HUMAN","tr|S5FZ81|S5FZ81_HUMAN;sp|Q8WUB8|PHF10_HUMAN",3418,"S5FZ81","S5FZ81_HUMAN",null,null,"PHF10"]
["16.6187","19.7736","16.6181","17.6291",{"$nulls":3},"cleavage furrow formation;endocytosis;endosomal transport;endosome organization;intracellular protein transport;macropinocytosis;mitotic cytokinesis;negative regulation of endocytosis;negative regulation of protein localization to cell surface;plasma membrane tubulation;positive regulation of membrane protein ectodomain proteolysis;positive regulation of protein localization to cell surface;protein import","identical protein binding;phosphatidylinositol binding","cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;extrinsic component of membrane;membrane",{"$nulls":3},17,17,17,"39.2","39.2","39.2","65.264",0,"65.206",853110000,101,"0.233793",1,"1.0725","0.647471","sp|Q8WV41|SNX33_HUMAN;tr|H3BPR3|H3BPR3_HUMAN","sp|Q8WV41|SNX33_HUMAN",3433,"Q8WV41","SNX33_HUMAN","Sorting nexin-33",null,"SNX33"]
["18.2814","18.4438","18.3645","16.225",{"$nulls":3},"mRNA processing","metal ion binding;RNA binding","cytoplasm;nuclear speck",{"$nulls":3},6,5,5,"8.1",7,7,"118.72",0,"8.7342",90637000,6,"0.3722",1,"1.06788","0.995402","sp|Q9P2N5|RBM27_HUMAN;tr|U3KPZ7|U3KPZ7_HUMAN","sp|Q9P2N5|RBM27_HUMAN;tr|U3KPZ7|U3KPZ7_HUMAN",4646,"Q9P2N5","RBM27_HUMAN","RNA-binding protein 27",null,"RBM27"]
["17.6871","16.5953","15.9462","16.201",{"$nulls":3},"activation of protein kinase activity;amyloid fibril formation;apoptotic signaling pathway;cellular protein modification process;I-kappaB kinase/NF-kappaB signaling;lymph node development;necroptotic process;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of ligase activity;positive regulation of necroptotic process;positive regulation of NF-kappaB transcription factor activity;positive regulation of oxidoreductase activity;positive regulation of phosphatase activity;positive regulation of reactive oxygen species metabolic process;protein autophosphorylation;protein heterooligomerization;protein homooligomerization;regulation of activated T cell proliferation;regulation of activation-induced cell death of T cells;regulation of adaptive immune response;regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation;regulation of interferon-gamma production;regulation of T cell mediated cytotoxicity;signal transduction;spleen development;T cell differentiation in thymus;T cell homeostasis;thymus development","ATP binding;identical protein binding;NF-kappaB-inducing kinase activity;protein complex binding;protein kinase activity;protein serine/threonine kinase activity;transcription coactivator activity","cytosol;mitochondrion;plasma membrane","Cytosolic DNA-sensing pathway;Necroptosis;NOD-like receptor signaling pathway;TNF signaling pathway",null,null,2,2,2,"7.7","7.7","7.7","56.887","0.0013001","3.7139",24119000,7,"0.705185",1,"1.06758","1.9044","sp|Q9Y572|RIPK3_HUMAN;tr|H0YJN5|H0YJN5_HUMAN;tr|G3V2L1|G3V2L1_HUMAN","sp|Q9Y572|RIPK3_HUMAN;tr|H0YJN5|H0YJN5_HUMAN;tr|G3V2L1|G3V2L1_HUMAN",5032,"Q9Y572","RIPK3_HUMAN","Receptor-interacting serine/threonine-protein kinase 3",null,"RIPK3"]
["22.2249","18.3212","19.5099","18.9033",{"$nulls":4},"serine-type endopeptidase activity",{"$nulls":4},4,4,4,"10.6","10.6","10.6","45.112",0,"8.0585",181710000,11,"0.19156",1,"1.06646","0.539902","tr|A0A0C4DG44|A0A0C4DG44_HUMAN;sp|O43464|HTRA2_HUMAN;sp|P83110|HTRA3_HUMAN","tr|A0A0C4DG44|A0A0C4DG44_HUMAN;sp|O43464|HTRA2_HUMAN",402,"A0A0C4DG44","A0A0C4DG44_HUMAN",null,null,"HTRA2"]
["17.5853","18.203","17.5988","16.0589",{"$nulls":3},"glycoprotein catabolic process;N-acetylglucosamine metabolic process;protein deglycosylation;protein O-linked glycosylation","[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity;[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity;[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity;beta-N-acetylglucosaminidase activity;hyalurononglucosaminidase activity","cytosol;membrane;nucleus","Insulin resistance",null,null,6,6,6,"8.7","8.7","8.7","102.91",0,"17.954",147950000,13,"0.484443",1,"1.06528","1.28414","sp|O60502|OGA_HUMAN;tr|H7C3X0|H7C3X0_HUMAN","sp|O60502|OGA_HUMAN",475,"O60502","OGA_HUMAN","Protein O-GlcNAcase {ECO:0000303|PubMed:11148210, ECO:0000303|PubMed:11788610}","GA {ECO:0000303|PubMed:20863279}","MGEA5"]
["20.7517","20.9077","20.7507","18.7859",{"$nulls":3},"mRNA processing;RNA splicing","DNA binding transcription factor activity;metal ion binding;RNA binding","nucleoplasm;nucleus",{"$nulls":3},8,8,8,"26.1","26.1","26.1","37.404",0,"36.915",207430000,23,"0.404389",1,"1.06145","1.07708","sp|O95218|ZRAB2_HUMAN;tr|A0A0C4DGV5|A0A0C4DGV5_HUMAN","sp|O95218|ZRAB2_HUMAN;tr|A0A0C4DGV5|A0A0C4DGV5_HUMAN",703,"O95218","ZRAB2_HUMAN","Zinc finger Ran-binding domain-containing protein 2",null,"ZRANB2"]
["18.8919","20.4911","19.0428","18.2198",{"$nulls":3},"cellular defense response",{"$nulls":5},2,2,2,"21.2","21.2","21.2","16.15","0.00023663","5.1915",16295000,3,"0.444103",1,"1.06022","1.17898","sp|O75459|PAGE1_HUMAN","sp|O75459|PAGE1_HUMAN",574,"O75459","PAGE1_HUMAN","P antigen family member 1","AGE-1","PAGE1"]
["20.4188","19.8848","20.5795","17.6069",{"$nulls":3},"ribosome biogenesis","GTP binding;RNA binding","chromosome;mitochondrion;nucleolus",{"$nulls":3},9,9,9,"32.3","32.3","32.3","42.932",0,"36.677",338810000,19,"0.25503",1,"1.05863","0.701035","sp|A4D1E9|GTPBA_HUMAN;tr|C9J8R7|C9J8R7_HUMAN;tr|C9JNI1|C9JNI1_HUMAN;tr|C9JEQ8|C9JEQ8_HUMAN;tr|F8WBY0|F8WBY0_HUMAN;tr|F8WCN4|F8WCN4_HUMAN;tr|F8WBB5|F8WBB5_HUMAN","sp|A4D1E9|GTPBA_HUMAN;tr|C9J8R7|C9J8R7_HUMAN;tr|C9JNI1|C9JNI1_HUMAN",162,"A4D1E9","GTPBA_HUMAN","GTP-binding protein 10",null,"GTPBP10"]
["20.1738","19.6217","19.0164","18.6676",{"$nulls":9},4,4,4,"34.8","34.8","34.8","22.49",0,"9.4372",52699000,10,"1.07678",1,"1.05575","3.23355","tr|K7ER15|K7ER15_HUMAN;sp|Q9H0R4|HDHD2_HUMAN;tr|K7EMY7|K7EMY7_HUMAN;tr|K7EQD2|K7EQD2_HUMAN","tr|K7ER15|K7ER15_HUMAN;sp|Q9H0R4|HDHD2_HUMAN;tr|K7EMY7|K7EMY7_HUMAN",4141,"K7ER15","K7ER15_HUMAN",null,null,"HDHD2"]
["18.0901","18.8296","18.0601","16.7546",{"$nulls":5},"cytosol;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},10,10,10,"17.8","17.8","17.8","90.856",0,"27.183",99871000,21,"0.529132",1,"1.0525","1.40301","tr|A0A087WT45|A0A087WT45_HUMAN;sp|Q4V328|GRAP1_HUMAN;tr|A0A075B793|A0A075B793_HUMAN;tr|A0A087WXA6|A0A087WXA6_HUMAN;tr|A0A087WW92|A0A087WW92_HUMAN","tr|A0A087WT45|A0A087WT45_HUMAN;sp|Q4V328|GRAP1_HUMAN;tr|A0A075B793|A0A075B793_HUMAN",2635,"A0A087WT45","A0A087WT45_HUMAN",null,null,"GRIPAP1"]
["18.4466","19.0825","17.6027","17.8329",{"$nulls":3},"cellular response to camptothecin;cellular response to cisplatin;cellular response to DNA damage stimulus;cellular response to gamma radiation;cellular response to hydroxyurea;cellular response to ionizing radiation;chromosome organization involved in meiotic cell cycle;DNA recombinase assembly;DNA recombination;DNA repair;DNA synthesis involved in DNA repair;DNA unwinding involved in DNA replication;double-strand break repair via homologous recombination;interstrand cross-link repair;meiotic cell cycle;mitotic recombination;mitotic recombination-dependent replication fork processing;negative regulation of G0 to G1 transition;positive regulation of DNA ligation;protein homooligomerization;reciprocal meiotic recombination;regulation of double-strand break repair via homologous recombination;regulation of protein phosphorylation;replication fork processing;replication-born double-strand break repair via sister chromatid exchange;response to drug;response to glucoside;response to toxic substance;response to X-ray;strand displacement;strand invasion;telomere maintenance via recombination;telomere maintenance via telomere lengthening","ATP binding;chromatin binding;DNA polymerase binding;double-stranded DNA binding;four-way junction DNA binding;identical protein binding;protein C-terminus binding;recombinase activity;single-stranded DNA binding;single-stranded DNA-dependent ATPase activity","chromatin;condensed chromosome;condensed nuclear chromosome;cytoplasm;cytosol;lateral element;microtubule organizing center;mitochondrial matrix;mitochondrion;nuclear chromatin;nuclear chromosome;nuclear chromosome, telomeric region;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;PML body;protein complex;site of double-strand break","Fanconi anemia pathway;Homologous recombination;Pancreatic cancer;Pathways in cancer",null,null,3,3,3,"10.3","10.3","10.3","36.966","0.00024765","6.1759",88712000,7,"1.04374",1,"1.04678","3.09569","sp|Q06609|RAD51_HUMAN;tr|Q9NZG9|Q9NZG9_HUMAN;tr|E9PI54|E9PI54_HUMAN;tr|E9PJ30|E9PJ30_HUMAN;tr|E9PNT5|E9PNT5_HUMAN","sp|Q06609|RAD51_HUMAN",2114,"Q06609","RAD51_HUMAN","DNA repair protein RAD51 homolog 1","RAD51;sRAD51","RAD51"]
["21.7623","22.2032","21.8188","20.0662",{"$nulls":9},4,4,4,"26.1","26.1","26.1","17.634",0,"32.372",243370000,25,"0.433344",1,"1.04027","1.15123","tr|E9PM92|E9PM92_HUMAN;sp|O00193|SMAP_HUMAN;tr|E9PQA1|E9PQA1_HUMAN;tr|E9PRZ9|E9PRZ9_HUMAN","tr|E9PM92|E9PM92_HUMAN;sp|O00193|SMAP_HUMAN;tr|E9PQA1|E9PQA1_HUMAN;tr|E9PRZ9|E9PRZ9_HUMAN",199,"E9PM92","E9PM92_HUMAN",null,null,"C11orf58"]
["19.3597","20.1572","19.1497","18.292",{"$nulls":5},"mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,"15.9","15.9","15.9","17.459",0,"20.564",109030000,21,"0.660681",1,"1.0376","1.77182","tr|C9JU35|C9JU35_HUMAN;sp|Q9NPL8|TIDC1_HUMAN;tr|C9JR82|C9JR82_HUMAN","tr|C9JU35|C9JU35_HUMAN;sp|Q9NPL8|TIDC1_HUMAN;tr|C9JR82|C9JR82_HUMAN",4374,"C9JU35","C9JU35_HUMAN",null,null,"TIMMDC1"]
["20.0613","19.8039","17.9971","19.7951",{"$nulls":3},"cellular protein modification process;cellular response to interferon-beta;DNA replication initiation;G1/S transition of mitotic cell cycle;negative regulation of cAMP-mediated signaling;positive regulation of inclusion body assembly;positive regulation of neuron apoptotic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K48-linked ubiquitination;protein polyubiquitination;protein ubiquitination;response to growth factor","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;cytosol;nuclear speck;nucleoplasm;nucleus","Ubiquitin mediated proteolysis",null,null,4,3,3,"24.2","20.8","20.8","26.736","0.00023657","5.1879",50692000,4,"0.429473",1,"1.03648","1.14128","sp|P49427|UB2R1_HUMAN;tr|U3KQ77|U3KQ77_HUMAN;tr|U3KPV8|U3KPV8_HUMAN","sp|P49427|UB2R1_HUMAN;tr|U3KQ77|U3KQ77_HUMAN;tr|U3KPV8|U3KPV8_HUMAN",1574,"P49427","UB2R1_HUMAN","Ubiquitin-conjugating enzyme E2 R1",null,"CDC34"]
["21.9048","19.6233","20.2669","19.1893",{"$nulls":3},"galactose metabolic process","ATP binding;galactokinase activity;galactose binding","cytoplasm",{"$nulls":3},5,5,5,21,21,21,"47.635",0,"109.3",318070000,23,"0.302886",1,"1.03595","0.821149","tr|B7ZAX5|B7ZAX5_HUMAN;sp|Q01415|GALK2_HUMAN;tr|H0YLL8|H0YLL8_HUMAN;tr|H0YK10|H0YK10_HUMAN;tr|H0YNR7|H0YNR7_HUMAN;tr|H0YK30|H0YK30_HUMAN;tr|H0YND3|H0YND3_HUMAN;tr|H0YLL3|H0YLL3_HUMAN","tr|B7ZAX5|B7ZAX5_HUMAN;sp|Q01415|GALK2_HUMAN",2044,"B7ZAX5","B7ZAX5_HUMAN",null,null,"GALK2"]
["19.4988","20.5593","19.1356","18.8604",{"$nulls":4},"RNA binding",{"$nulls":4},2,2,2,18,18,18,"15.108","0.00024882","6.2619",101560000,13,"0.697873",1,"1.03108","1.88231","tr|H3BPG5|H3BPG5_HUMAN;tr|H3BV80|H3BV80_HUMAN;tr|H3BMS0|H3BMS0_HUMAN;tr|H3BMM9|H3BMM9_HUMAN;tr|H3BTC0|H3BTC0_HUMAN;sp|Q15287|RNPS1_HUMAN","tr|H3BPG5|H3BPG5_HUMAN;tr|H3BV80|H3BV80_HUMAN;tr|H3BMS0|H3BMS0_HUMAN;tr|H3BMM9|H3BMM9_HUMAN;tr|H3BTC0|H3BTC0_HUMAN;sp|Q15287|RNPS1_HUMAN",2468,"H3BPG5","H3BPG5_HUMAN"]
[1,"18.6767",1,"16.6276",{"$nulls":9},3,3,3,"8.8","8.8","8.8","51.814","0.00024994","6.3513",23148000,6,"0.0274718",1,"1.02458","0.0868504","tr|K7ESN3|K7ESN3_HUMAN;sp|Q8N2G8|GHDC_HUMAN","tr|K7ESN3|K7ESN3_HUMAN;sp|Q8N2G8|GHDC_HUMAN",3207,"K7ESN3","K7ESN3_HUMAN",null,null,"GHDC"]
["23.9637","23.7579","24.0417","21.6312",{"$nulls":3},"generation of precursor metabolites and energy;mitochondrial electron transport, cytochrome c to oxygen","cytochrome-c oxidase activity","integral component of membrane;mitochondrial inner membrane;mitochondrion","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,3,3,3,"29.3","29.3","29.3","8.7813","0.00025478","6.7707",883950000,50,"0.313122",1,"1.02432","0.846811","sp|P09669|COX6C_HUMAN","sp|P09669|COX6C_HUMAN",954,"P09669","COX6C_HUMAN","Cytochrome c oxidase subunit 6C",null,"COX6C"]
["17.8819","17.5845","18.1677","15.2504",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitinyl hydrolase activity","Flemming body;nucleoplasm",{"$nulls":3},4,4,4,"11.1","11.1","11.1","49.058",0,"12.945",132720000,24,"0.254014",1,"1.0241","0.698478","tr|H0YLB7|H0YLB7_HUMAN;tr|H0YKU8|H0YKU8_HUMAN;tr|Q6JHV3|Q6JHV3_HUMAN;tr|H0YMI4|H0YMI4_HUMAN;sp|Q9Y6I4|UBP3_HUMAN;tr|H0YL81|H0YL81_HUMAN;tr|H0YLG0|H0YLG0_HUMAN","tr|H0YLB7|H0YLB7_HUMAN;tr|H0YKU8|H0YKU8_HUMAN;tr|Q6JHV3|Q6JHV3_HUMAN;tr|H0YMI4|H0YMI4_HUMAN;sp|Q9Y6I4|UBP3_HUMAN",5097,"H0YLB7","H0YLB7_HUMAN",null,null,"USP3"]
["14.7493","16.2905","13.4217","15.5752",{"$nulls":3},"CENP-A containing nucleosome assembly;chromatin remodeling;covalent chromatin modification;DNA-templated transcription, initiation;negative regulation of DNA binding;negative regulation of transcription, DNA-templated;nucleosome assembly;nucleosome positioning;positive regulation of transcription, DNA-templated;positive regulation of viral transcription","histone binding;metal ion binding","nucleoplasm;nucleus;RSF complex",{"$nulls":3},5,5,5,"4.2","4.2","4.2","163.82","0.00025681","6.9464",37956000,8,"0.283044",1,"1.02142","0.771402","sp|Q96T23|RSF1_HUMAN;tr|H0YCN2|H0YCN2_HUMAN;tr|H0YER1|H0YER1_HUMAN;tr|H7C306|H7C306_HUMAN","sp|Q96T23|RSF1_HUMAN;tr|H0YCN2|H0YCN2_HUMAN;tr|H0YER1|H0YER1_HUMAN",3831,"Q96T23","RSF1_HUMAN","Remodeling and spacing factor 1","sf-1","RSF1"]
["20.4025","18.4376","20.4842","16.3193",{"$nulls":9},2,2,2,"9.1","9.1","9.1","46.393",0,"16.151",250200000,19,"0.153946",1,"1.01829","0.442238","tr|A0A087WTX2|A0A087WTX2_HUMAN;sp|Q92504|S39A7_HUMAN;tr|A2AAT0|A2AAT0_HUMAN","tr|A0A087WTX2|A0A087WTX2_HUMAN;sp|Q92504|S39A7_HUMAN;tr|A2AAT0|A2AAT0_HUMAN",3481,"A0A087WTX2"]
["17.8667","18.3725","17.5911","16.6119",{"$nulls":3},"maturation of SSU-rRNA;positive regulation of ribosomal small subunit export from nucleus;positive regulation of rRNA processing;ribosomal small subunit biogenesis;rRNA processing","ATP binding;metal ion binding;protein serine/threonine kinase activity","cytoplasm;cytosol;nucleoplasm;preribosome, small subunit precursor","Ribosome biogenesis in eukaryotes",null,null,8,8,8,"19.9","19.9","19.9","63.282",0,"31.785",255400000,46,"0.686297",1,"1.0181","1.84759","sp|Q9BVS4|RIOK2_HUMAN;tr|H0Y919|H0Y919_HUMAN","sp|Q9BVS4|RIOK2_HUMAN",4016,"Q9BVS4","RIOK2_HUMAN","Serine/threonine-protein kinase RIO2",null,"RIOK2"]
["19.4163","18.3778","18.7613","16.9998",{"$nulls":3},"regulation of dendrite development","oxidoreductase activity;zinc ion binding","mitochondrial outer membrane",{"$nulls":3},5,5,5,"16.4","16.4","16.4","43.589",0,"12.6",91248000,13,"0.371721",1,"1.01652","0.994191","sp|Q8WWV3|RT4I1_HUMAN;tr|G3V1R2|G3V1R2_HUMAN","sp|Q8WWV3|RT4I1_HUMAN",3458,"Q8WWV3","RT4I1_HUMAN","Reticulon-4-interacting protein 1, mitochondrial",null,"RTN4IP1"]
["15.3153","19.7485","15.8581","17.1786",{"$nulls":3},"negative regulation of apoptotic process;N-terminal protein amino acid acetylation;smooth muscle cell proliferation","peptide alpha-N-acetyltransferase activity","cytoplasm;NatC complex",{"$nulls":3},5,5,5,"9.4","9.4","9.4","83.638","0.00026652","7.7133",73173000,10,"0.152413",1,"1.01351","0.438209","sp|Q5VZE5|NAA35_HUMAN","sp|Q5VZE5|NAA35_HUMAN",2771,"Q5VZE5","NAA35_HUMAN","N-alpha-acetyltransferase 35, NatC auxiliary subunit",null,"NAA35"]
["19.2202","18.2961","18.6802","16.817",{"$nulls":3},"heart development;negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity","nucleus",{"$nulls":3},12,12,6,"27.7","27.7",13,"76.666",0,"49.949",351980000,66,"0.36245",1,"1.00952","0.970784","sp|Q9BQ70|TCF25_HUMAN;tr|H3BTU3|H3BTU3_HUMAN;tr|H3BQ53|H3BQ53_HUMAN;tr|H3BSS3|H3BSS3_HUMAN;tr|Q9H384|Q9H384_HUMAN;tr|H3BRP4|H3BRP4_HUMAN","sp|Q9BQ70|TCF25_HUMAN;tr|H3BTU3|H3BTU3_HUMAN;tr|H3BQ53|H3BQ53_HUMAN",3913,"Q9BQ70","TCF25_HUMAN","Transcription factor 25","CF-25","TCF25"]
["19.5274","18.615","19.2728","16.8634",{"$nulls":3},"activation of MAPK activity;CAMKK-AMPK signaling cascade;cell cycle arrest;cellular response to ethanol;cellular response to glucose starvation;cellular response to hydrogen peroxide;cellular response to hypoxia;cellular response to nutrient levels;cellular response to organonitrogen compound;cellular response to prostaglandin E stimulus;cholesterol biosynthetic process;cold acclimation;fatty acid biosynthetic process;fatty acid homeostasis;fatty acid oxidation;glucose homeostasis;glucose metabolic process;lipid biosynthetic process;macroautophagy;negative regulation of apoptotic process;negative regulation of glucose import in response to insulin stimulus;negative regulation of glucosylceramide biosynthetic process;negative regulation of lipid catabolic process;negative regulation of TOR signaling;positive regulation of autophagy;positive regulation of cell proliferation;positive regulation of cholesterol biosynthetic process;positive regulation of gene expression;positive regulation of glycolytic process;positive regulation of skeletal muscle tissue development;protein heterooligomerization;protein phosphorylation;regulation of circadian rhythm;regulation of energy homeostasis;regulation of macroautophagy;regulation of peptidyl-serine phosphorylation;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;regulation of vesicle-mediated transport;response to activity;response to caffeine;response to camptothecin;response to gamma radiation;response to hypoxia;response to UV;rhythmic process;signal transduction;transcription, DNA-templated;Wnt signaling pathway","[acetyl-CoA carboxylase] kinase activity;[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity;AMP-activated protein kinase activity;ATP binding;cAMP-dependent protein kinase activity;chromatin binding;histone serine kinase activity;metal ion binding;protein C-terminus binding;protein kinase activity;tau-protein kinase activity","apical plasma membrane;cytoplasm;cytosol;intracellular;nuclear speck;nucleoplasm;nucleotide-activated protein kinase complex;nucleus","Adipocytokine signaling pathway;AMPK signaling pathway;Apelin signaling pathway;Autophagy - animal;Circadian rhythm;Fluid shear stress and atherosclerosis;FoxO signaling pathway;Glucagon signaling pathway;Hypertrophic cardiomyopathy (HCM);Insulin resistance;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;mTOR signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Oxytocin signaling pathway;PI3K-Akt signaling pathway;Thermogenesis;Tight junction",null,null,8,8,8,"18.4","18.4","18.4","64.009",0,"17.729",151090000,19,"0.285961",1,"1.00313","0.778718","sp|Q13131|AAPK1_HUMAN;tr|Q96E92|Q96E92_HUMAN;tr|A0A087WXX9|A0A087WXX9_HUMAN;sp|P54646|AAPK2_HUMAN","sp|Q13131|AAPK1_HUMAN",2207,"Q13131","AAPK1_HUMAN","5'-AMP-activated protein kinase catalytic subunit alpha-1","MPK subunit alpha-1","PRKAA1"]
["19.9476","19.3188","19.8608","17.408",{"$nulls":3},"mRNA processing;regulation of alternative mRNA splicing, via spliceosome;regulation of apoptotic process;RNA splicing","mRNA binding;RNA binding","cytoplasm;nuclear speck;spliceosomal complex","Spliceosome",null,null,31,31,31,"37.8","37.8","37.8","100.18",0,"146.85",2664200000,251,"0.290025",1,"0.998813","0.788908","sp|P49756|RBM25_HUMAN;tr|E9PQU5|E9PQU5_HUMAN;tr|H0YE46|H0YE46_HUMAN;tr|E9PSE8|E9PSE8_HUMAN","sp|P49756|RBM25_HUMAN",1596,"P49756","RBM25_HUMAN","RNA-binding protein 25",null,"RBM25"]
["20.0503","21.0007","17.8659","21.2043",{"$nulls":3},"cilium assembly;nervous system development;neuron projection development;protein homotrimerization","enzyme binding;identical protein binding","cytoplasm;cytosol;dendrite;extracellular space;membrane;neuronal cell body;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},9,9,9,"22.7","22.7","22.7","53.488",0,"73.768",355900000,32,"0.203563",1,"0.990373","0.570654","sp|Q9UBB4|ATX10_HUMAN;tr|B1AHE4|B1AHE4_HUMAN;tr|B1AHE3|B1AHE3_HUMAN","sp|Q9UBB4|ATX10_HUMAN",4653,"Q9UBB4","ATX10_HUMAN","Ataxin-10",null,"ATXN10"]
["16.7494","15.1939","15.5018","14.4607",{"$nulls":3},"cellular response to DNA damage stimulus;DNA repair;mitotic cell cycle checkpoint;response to ionizing radiation;snRNA processing;snRNA transcription from RNA polymerase II promoter",null,"cytoplasm;integrator complex;nucleolus;nucleoplasm;nucleus;SOSS complex",{"$nulls":3},2,2,2,"3.8","3.8","3.8","118.07",0,"11.443",52061000,17,"0.396986",1,"0.990367","1.05823","sp|Q68E01|INT3_HUMAN;tr|A0A096LNW8|A0A096LNW8_HUMAN","sp|Q68E01|INT3_HUMAN;tr|A0A096LNW8|A0A096LNW8_HUMAN",2797,"Q68E01","INT3_HUMAN","Integrator complex subunit 3","nt3","INTS3"]
["18.1962","17.719","16.8635","17.0741",{"$nulls":3},"androgen receptor signaling pathway;circadian rhythm;intracellular steroid hormone receptor signaling pathway;mRNA processing;mRNA stabilization;nuclear-transcribed mRNA catabolic process;positive regulation of circadian rhythm;positive regulation of mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of alternative mRNA splicing, via spliceosome;RNA splicing;transcription initiation from RNA polymerase II promoter","ATP binding;core promoter sequence-specific DNA binding;ligand-dependent nuclear receptor transcription coactivator activity;phosphoprotein binding;receptor activity;RNA binding;RNA polymerase II transcription cofactor activity;thyroid hormone receptor binding;transcription coactivator activity;transcription cofactor activity;vitamin D receptor binding","extracellular exosome;mediator complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},8,8,7,"10.4","10.4","9.2","108.66",0,"31.635",122130000,22,"1.20027",1,"0.988791","3.79144","sp|Q9Y2W1|TR150_HUMAN","sp|Q9Y2W1|TR150_HUMAN",4943,"Q9Y2W1","TR150_HUMAN","Thyroid hormone receptor-associated protein 3",null,"THRAP3"]
["22.9943","24.139","22.6776","22.4793",{"$nulls":3},"histone mRNA metabolic process;mRNA splicing, via spliceosome;nuclear import;RNA splicing;spliceosomal snRNP assembly;termination of RNA polymerase II transcription","RNA binding","catalytic step 2 spliceosome;cytosol;methylosome;nucleoplasm;pICln-Sm protein complex;small nuclear ribonucleoprotein complex;small nucleolar ribonucleoprotein complex;SMN-Sm protein complex;spliceosomal complex;U1 snRNP;U12-type spliceosomal complex;U4 snRNP;U7 snRNP","Spliceosome",null,null,3,3,3,"31.4","31.4","31.4","9.7251",0,"12.701",373830000,45,"0.636378",1,"0.988196","1.70123","sp|P62306|RUXF_HUMAN;tr|A0A0B4J254|A0A0B4J254_HUMAN;tr|F8W0W6|F8W0W6_HUMAN","sp|P62306|RUXF_HUMAN;tr|A0A0B4J254|A0A0B4J254_HUMAN;tr|F8W0W6|F8W0W6_HUMAN",1888,"P62306","RUXF_HUMAN","Small nuclear ribonucleoprotein F","nRNP-F","SNRPF"]
["16.899","17.1338","16.9234","15.1348",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;intra-Golgi vesicle-mediated transport;protein transport",null,"Golgi apparatus;Golgi membrane;Golgi transport complex;trans-Golgi network membrane",{"$nulls":3},6,6,6,"8.8","8.8","8.8","108.98",0,"10.817",58453000,10,"0.411279",1,"0.987314","1.09466","sp|Q8WTW3|COG1_HUMAN;tr|A0A087WVI0|A0A087WVI0_HUMAN;tr|E9PBL8|E9PBL8_HUMAN;tr|J3KSY3|J3KSY3_HUMAN;tr|J3QKY9|J3QKY9_HUMAN;tr|J3QLT5|J3QLT5_HUMAN","sp|Q8WTW3|COG1_HUMAN;tr|A0A087WVI0|A0A087WVI0_HUMAN;tr|E9PBL8|E9PBL8_HUMAN",3412,"Q8WTW3","COG1_HUMAN","Conserved oligomeric Golgi complex subunit 1","OG complex subunit 1","COG1"]
["19.0103","18.8234","19.1601","16.7085",{"$nulls":3},"cell-matrix adhesion;glutamate secretion;negative regulation of protein localization to plasma membrane;negative regulation of stress fiber assembly;neurotransmitter secretion;signal transduction","signal transducer activity","cytoplasm;cytosol;focal adhesion;presynaptic active zone",{"$nulls":3},24,24,19,"27.5","27.5","22.4","135.78",0,"150.3",1469100000,197,"0.294139",1,"0.982544","0.799223","sp|Q13136|LIPA1_HUMAN;tr|E9PJZ7|E9PJZ7_HUMAN;tr|H0YEF9|H0YEF9_HUMAN;tr|H0YDW2|H0YDW2_HUMAN;tr|E9PPF6|E9PPF6_HUMAN;tr|E9PID5|E9PID5_HUMAN;tr|H0YD72|H0YD72_HUMAN;tr|H0YF15|H0YF15_HUMAN;tr|H0YIJ4|H0YIJ4_HUMAN;tr|H0YHJ4|H0YHJ4_HUMAN","sp|Q13136|LIPA1_HUMAN;tr|E9PJZ7|E9PJZ7_HUMAN",2208,"Q13136","LIPA1_HUMAN","Liprin-alpha-1",null,"PPFIA1"]
["18.9721","19.6219","19.1424","17.4887",{"$nulls":3},"dendritic spine development;embryonic process involved in female pregnancy;fatty acid transport;lipid biosynthetic process;lipid metabolic process;long-chain fatty-acyl-CoA biosynthetic process;negative regulation of prostaglandin secretion;positive regulation of cell growth;response to interleukin-15;response to nutrient;triglyceride metabolic process","arachidonate-CoA ligase activity;ATP binding;decanoate--CoA ligase activity;long-chain fatty acid-CoA ligase activity;very long-chain fatty acid-CoA ligase activity","cytoplasm;endoplasmic reticulum membrane;ER-mitochondrion membrane contact site;extracellular exosome;integral component of membrane;lipid droplet;membrane;mitochondrial outer membrane;neuronal cell body;peroxisomal membrane","Adipocytokine signaling pathway;Fatty acid biosynthesis;Fatty acid degradation;Fatty acid metabolism;Ferroptosis;Metabolic pathways;Peroxisome;PPAR signaling pathway;Thermogenesis",null,null,13,10,10,25,"19.1","19.1","79.187",0,"67.796",271150000,34,"0.41523",1,"0.981442","1.10476","sp|O60488|ACSL4_HUMAN;tr|H0Y9A0|H0Y9A0_HUMAN;tr|D6RFW9|D6RFW9_HUMAN;tr|D6RDA8|D6RDA8_HUMAN;tr|D6RD96|D6RD96_HUMAN;tr|D6RF95|D6RF95_HUMAN","sp|O60488|ACSL4_HUMAN",472,"O60488","ACSL4_HUMAN","Long-chain-fatty-acid--CoA ligase 4",null,"ACSL4"]
["15.6784","16.9988","16.5368","14.1829",{"$nulls":3},"snRNA processing;snRNA transcription from RNA polymerase II promoter","transmembrane signaling receptor activity","actin cytoskeleton;integrator complex;nucleoplasm;nucleus",{"$nulls":3},9,9,9,"13.8","13.8","13.8","100.39",0,"22.96",191810000,43,"0.264669",1,"0.978752","0.725275","sp|Q9UL03|INT6_HUMAN;tr|G5E9X1|G5E9X1_HUMAN;tr|B3KQH5|B3KQH5_HUMAN;tr|C9JVX2|C9JVX2_HUMAN;tr|C9JXP6|C9JXP6_HUMAN;tr|C9J885|C9J885_HUMAN;tr|C9K0V7|C9K0V7_HUMAN;tr|F8WAV7|F8WAV7_HUMAN","sp|Q9UL03|INT6_HUMAN;tr|G5E9X1|G5E9X1_HUMAN;tr|B3KQH5|B3KQH5_HUMAN",4800,"Q9UL03","INT6_HUMAN","Integrator complex subunit 6","nt6","INTS6"]
["20.6375","21.0609","20.9772","18.7693",{"$nulls":3},"heme biosynthetic process;protoporphyrinogen IX biosynthetic process","uroporphyrinogen decarboxylase activity","cytosol;nucleoplasm","Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,8,8,8,"38.4","38.4","38.4","40.786",0,"36.906",208600000,24,"0.321682",1,"0.975966","0.868278","sp|P06132|DCUP_HUMAN;tr|H0Y5R6|H0Y5R6_HUMAN;tr|Q5T446|Q5T446_HUMAN","sp|P06132|DCUP_HUMAN;tr|H0Y5R6|H0Y5R6_HUMAN;tr|Q5T446|Q5T446_HUMAN",869,"P06132","DCUP_HUMAN","Uroporphyrinogen decarboxylase","PD;RO-D","UROD"]
["20.5456","20.5811","19.621","19.5556",{"$nulls":3},"phosphate-containing compound metabolic process","acylphosphatase activity","extracellular exosome","Metabolic pathways;Pyruvate metabolism",null,null,4,4,4,"46.5","46.5","46.5","11.261",0,"8.5103",70962000,5,"2.83826",1,"0.975057","26.2214","sp|P07311|ACYP1_HUMAN;tr|G3V2U7|G3V2U7_HUMAN;tr|G3V3F8|G3V3F8_HUMAN;tr|G3V597|G3V597_HUMAN","sp|P07311|ACYP1_HUMAN;tr|G3V2U7|G3V2U7_HUMAN;tr|G3V3F8|G3V3F8_HUMAN;tr|G3V597|G3V597_HUMAN",895,"P07311","ACYP1_HUMAN","Acylphosphatase-1",null,"ACYP1"]
["22.0681","21.6877","20.8589","20.9511",{"$nulls":3},"DNA recombination;DNA repair;forebrain morphogenesis;lateral ventricle development;midbrain development;protein deubiquitination;regulation of proteasomal protein catabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated;ubiquitin-dependent protein catabolic process","endopeptidase inhibitor activity;proteasome binding;RNA binding;thiol-dependent ubiquitin-specific protease activity","cytosol;cytosolic proteasome complex;Ino80 complex;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},11,11,11,"41.9","41.9","41.9","37.606",0,"56.406",565720000,52,"1.41839",1,"0.972937","4.9714","sp|Q9Y5K5|UCHL5_HUMAN;tr|Q5LJA9|Q5LJA9_HUMAN;tr|Q5LJA5|Q5LJA5_HUMAN;tr|Q5LJB0|Q5LJB0_HUMAN;tr|H0Y6Y4|H0Y6Y4_HUMAN;tr|H0Y4E0|H0Y4E0_HUMAN;tr|H0Y4K0|H0Y4K0_HUMAN;tr|H0Y636|H0Y636_HUMAN","sp|Q9Y5K5|UCHL5_HUMAN;tr|Q5LJA9|Q5LJA9_HUMAN;tr|Q5LJA5|Q5LJA5_HUMAN;tr|Q5LJB0|Q5LJB0_HUMAN;tr|H0Y6Y4|H0Y6Y4_HUMAN",5041,"Q9Y5K5","UCHL5_HUMAN","Ubiquitin carboxyl-terminal hydrolase isozyme L5","CH-L5","UCHL5"]
["21.7762","22.0885","22.0402","19.8792",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},5,5,5,"34.4","34.4","34.4","18.529",0,"36.131",408980000,16,"0.330715",1,"0.97265","0.890947","tr|A6NJD9|A6NJD9_HUMAN;sp|Q16540|RM23_HUMAN;tr|A8MVT4|A8MVT4_HUMAN;tr|A8MYK1|A8MYK1_HUMAN;tr|H7C2P7|H7C2P7_HUMAN","tr|A6NJD9|A6NJD9_HUMAN;sp|Q16540|RM23_HUMAN;tr|A8MVT4|A8MVT4_HUMAN;tr|A8MYK1|A8MYK1_HUMAN;tr|H7C2P7|H7C2P7_HUMAN",5164,"A6NJD9","A6NJD9_HUMAN",null,null,"MRPL23"]
["23.4925","22.9428","23.8415","20.6504",{"$nulls":3},"ER to Golgi vesicle-mediated transport",null,"endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi membrane;integral component of membrane;intracellular membrane-bounded organelle;membrane;nucleoplasm",{"$nulls":3},7,7,7,29,29,29,"32.592",0,"106.09",1182300000,58,"0.215138",1,"0.971717","0.600162","sp|Q969X5|ERGI1_HUMAN;tr|F2Z3Q5|F2Z3Q5_HUMAN;tr|F2Z2U2|F2Z2U2_HUMAN","sp|Q969X5|ERGI1_HUMAN",3587,"Q969X5","ERGI1_HUMAN","Endoplasmic reticulum-Golgi intermediate compartment protein 1",null,"ERGIC1"]
["17.6166","15.5974","17.7169","13.561",{"$nulls":3},"adult heart development;adult walking behavior;aorta morphogenesis;atrioventricular canal development;blood circulation;blood vessel remodeling;cardiac septum morphogenesis;central nervous system development;chromatin remodeling;cognition;covalent chromatin modification;cranial nerve development;embryonic hindlimb morphogenesis;epithelium development;face development;female genitalia development;genitalia development;heart morphogenesis;in utero embryonic development;inner ear morphogenesis;innervation;limb development;nose development;olfactory behavior;olfactory bulb development;olfactory nerve development;palate development;positive regulation of multicellular organism growth;positive regulation of transcription from RNA polymerase II promoter;regulation of growth hormone secretion;regulation of neurogenesis;regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;regulation of transcription, DNA-templated;retina development in camera-type eye;right ventricular compact myocardium morphogenesis;rRNA processing;semicircular canal morphogenesis;sensory perception of sound;skeletal system development;T cell differentiation;transcription, DNA-templated;ventricular trabecula myocardium morphogenesis","ATP binding;chromatin binding;helicase activity;promoter-specific chromatin binding;RNA polymerase II proximal promoter sequence-specific DNA binding","nucleolus;nucleus",{"$nulls":3},36,32,29,"17.3","16.4","14.8","335.92",0,"115.21",762720000,102,"0.145148",1,"0.968077","0.419047","sp|Q9P2D1|CHD7_HUMAN","sp|Q9P2D1|CHD7_HUMAN",4639,"Q9P2D1","CHD7_HUMAN","Chromodomain-helicase-DNA-binding protein 7","HD-7","CHD7"]
["22.0564","21.111","21.9001","19.3334",{"$nulls":3},"neutrophil degranulation","heme binding;steroid binding","cell body;endoplasmic reticulum;extracellular exosome;integral component of plasma membrane;membrane;neuron projection;neuronal cell body;plasma membrane;smooth endoplasmic reticulum membrane;specific granule membrane;synapse",{"$nulls":3},5,5,5,39,39,39,"21.671",0,"136.52",206810000,17,"0.257389",1,"0.966911","0.706972","sp|O00264|PGRC1_HUMAN","sp|O00264|PGRC1_HUMAN",207,"O00264","PGRC1_HUMAN","Membrane-associated progesterone receptor component 1","PR","PGRMC1"]
["18.6464","17.2268","18.2503","15.6951",{"$nulls":4},"metal ion binding","nuclear speck",{"$nulls":3},13,13,13,"19.2","19.2","19.2","108.94",0,"49.995",440940000,73,"0.238558",1,"0.963873","0.659512","tr|E7ERS3|E7ERS3_HUMAN;sp|Q86VM9|ZCH18_HUMAN;tr|H3BRN6|H3BRN6_HUMAN;tr|H3BRH3|H3BRH3_HUMAN;tr|H3BPD0|H3BPD0_HUMAN","tr|E7ERS3|E7ERS3_HUMAN;sp|Q86VM9|ZCH18_HUMAN",5198,"E7ERS3","E7ERS3_HUMAN",null,null,"ZC3H18"]
["19.0432","18.4047","19.1772","16.346",{"$nulls":4},"RNA binding","cytosol;nucleoplasm",{"$nulls":3},6,3,1,"16.4","7.8","3.1","42.835","0.00024522","5.8816",41530000,14,"0.239992",1,"0.962317","0.663133","tr|F8W8I6|F8W8I6_HUMAN;sp|P31483|TIA1_HUMAN;tr|E5RGV5|E5RGV5_HUMAN;tr|E5RG67|E5RG67_HUMAN;tr|F8WE16|F8WE16_HUMAN","tr|F8W8I6|F8W8I6_HUMAN;sp|P31483|TIA1_HUMAN;tr|E5RGV5|E5RGV5_HUMAN;tr|E5RG67|E5RG67_HUMAN",1332,"F8W8I6","F8W8I6_HUMAN",null,null,"TIA1"]
["21.1823","18.9462","19.6952","18.5094",{"$nulls":3},"endocytosis;endosomal transport;intracellular protein transport;neutrophil degranulation;protein transport","clathrin binding","azurophil granule membrane;cytoplasm;cytosol;early endosome;endosome;extracellular exosome;membrane;plasma membrane;specific granule membrane",{"$nulls":3},4,4,3,13,13,"10.4","53.818",0,"15.79",194420000,12,"0.27854",1,"0.961946","0.760102","sp|O60784|TOM1_HUMAN;tr|Q6UW50|Q6UW50_HUMAN;tr|B0QY01|B0QY01_HUMAN;tr|F8WB30|F8WB30_HUMAN;tr|F8WAW7|F8WAW7_HUMAN;tr|F8WE29|F8WE29_HUMAN;tr|F8WBB0|F8WBB0_HUMAN;tr|H7BYN7|H7BYN7_HUMAN","sp|O60784|TOM1_HUMAN;tr|Q6UW50|Q6UW50_HUMAN;tr|B0QY01|B0QY01_HUMAN",501,"O60784","TOM1_HUMAN","Target of Myb protein 1",null,"TOM1"]
["17.4231","18.8803","16.5453","17.8354",{"$nulls":3},"autophagy;endocytic recycling;Golgi organization;Golgi vesicle transport;lipid transport;lysosomal transport;protein transport;retrograde transport, endosome to Golgi",null,"cytosol;EARP complex;GARP complex;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;membrane;nucleolus;recycling endosome;trans-Golgi network membrane",{"$nulls":3},5,5,5,"11.6","11.6","11.6","86.041",0,"21.187",111040000,21,"0.369225",1,"0.961318","0.987883","sp|Q9UID3|VPS51_HUMAN;tr|E9PQD5|E9PQD5_HUMAN;tr|E9PRV0|E9PRV0_HUMAN;tr|E9PKX7|E9PKX7_HUMAN;tr|E9PKE5|E9PKE5_HUMAN;tr|E9PMB6|E9PMB6_HUMAN;tr|E9PQN6|E9PQN6_HUMAN;tr|H0YEE1|H0YEE1_HUMAN;tr|E9PJ36|E9PJ36_HUMAN","sp|Q9UID3|VPS51_HUMAN",4752,"Q9UID3","VPS51_HUMAN","Vacuolar protein sorting-associated protein 51 homolog",null,"VPS51"]
["17.5737","18.0862","17.0589","16.6828",{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},5,4,4,"6.5","5.4","5.4","125.87",0,"12.346",49129000,17,"1.02453",1,"0.95915","3.0176","sp|O95104|SFR15_HUMAN","sp|O95104|SFR15_HUMAN",690,"O95104","SFR15_HUMAN","Splicing factor, arginine/serine-rich 15",null,"SCAF4"]
["18.6741","19.3192","19.4879","16.589",{"$nulls":5},"Golgi apparatus;integral component of membrane;nucleoplasm;trans-Golgi network",{"$nulls":3},4,4,4,"11.7","11.7","11.7","47.879",0,"46.644",89405000,14,"0.232933",1,"0.958195","0.645296","tr|J3KQ45|J3KQ45_HUMAN;tr|F8W8W7|F8W8W7_HUMAN;sp|O43493|TGON2_HUMAN","tr|J3KQ45|J3KQ45_HUMAN;tr|F8W8W7|F8W8W7_HUMAN;sp|O43493|TGON2_HUMAN",405,"J3KQ45","J3KQ45_HUMAN",null,null,"TGOLN2"]
["17.3876","16.8703","18.1124","14.2291",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;rRNA transcription;transcription from RNA polymerase III promoter;transcription initiation from RNA polymerase III promoter;transcription, DNA-templated;tRNA transcription;tRNA transcription from RNA polymerase III promoter","RNA polymerase III type 1 promoter sequence-specific DNA binding;RNA polymerase III type 2 promoter sequence-specific DNA binding;transcription factor activity, RNA polymerase III transcription factor binding","intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;transcription factor TFIIIC complex",{"$nulls":3},23,23,23,"14.8","14.8","14.8","238.87",0,"71.79",699910000,85,"0.171916",1,"0.958183","0.489172","sp|Q12789|TF3C1_HUMAN;tr|H3BRD0|H3BRD0_HUMAN;tr|H3BU55|H3BU55_HUMAN;tr|I3L1Z3|I3L1Z3_HUMAN;tr|H3BU37|H3BU37_HUMAN","sp|Q12789|TF3C1_HUMAN",2158,"Q12789","TF3C1_HUMAN","General transcription factor 3C polypeptide 1",null,"GTF3C1"]
["18.2405","18.7491","17.9325","17.1408",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion","Ribosome",null,null,7,7,7,"18.4","18.4","18.4","48.006",0,"27.257",307140000,32,"0.747979",1,"0.958108","2.03626","sp|P82675|RT05_HUMAN","sp|P82675|RT05_HUMAN",1992,"P82675","RT05_HUMAN","28S ribosomal protein S5, mitochondrial","5mt;RP-S5","MRPS5"]
["21.2928","22.1141","20.4716","21.0235",{"$nulls":3},"cell redox homeostasis;cellular copper ion homeostasis;copper ion transport;eye development;oxidation-reduction process;respiratory chain complex IV assembly","copper ion binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrion;myofibril","Central carbon metabolism in cancer",null,null,6,6,6,"31.6","31.6","31.6","29.81",0,"50.425",430760000,29,"0.714266",1,"0.955873","1.93201","sp|O43819|SCO2_HUMAN;tr|C9JBU1|C9JBU1_HUMAN","sp|O43819|SCO2_HUMAN",441,"O43819","SCO2_HUMAN","Protein SCO2 homolog, mitochondrial",null,"SCO2"]
["18.9072",1,1,"16.9972",{"$nulls":3},"chromatin silencing","DNA binding;protein heterodimerization activity","extracellular exosome;nuclear chromatin;nucleosome;nucleus","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,5,2,2,"57.7","10.8","10.8","13.995","0.00023629","5.1761",96839000,8,"0.0250997",1,"0.954981","0.0795418","sp|Q8IUE6|H2A2B_HUMAN","sp|Q8IUE6|H2A2B_HUMAN",3101,"Q8IUE6","H2A2B_HUMAN","Histone H2A type 2-B",null,"HIST2H2AB"]
["21.5711","22.2893","21.2535","20.6977",{"$nulls":3},"brain development;lipid catabolic process;lipid metabolic process;nervous system development;spermatogenesis","1-alkyl-2-acetylglycerophosphocholine esterase activity;identical protein binding;phospholipase A2 activity;platelet-activating factor acetyltransferase activity;protein heterodimerization activity","cytoplasm;cytosol;extracellular exosome;membrane","Ether lipid metabolism;Metabolic pathways",null,null,8,8,8,"43.3","43.3","43.3","25.734",0,"54.457",372390000,36,"0.768889",1,"0.954639","2.10236","sp|Q15102|PA1B3_HUMAN;tr|M0R389|M0R389_HUMAN;tr|M0R1K3|M0R1K3_HUMAN;tr|M0QXS6|M0QXS6_HUMAN;tr|M0R323|M0R323_HUMAN;tr|M0QZT2|M0QZT2_HUMAN","sp|Q15102|PA1B3_HUMAN;tr|M0R389|M0R389_HUMAN;tr|M0R1K3|M0R1K3_HUMAN;tr|M0QXS6|M0QXS6_HUMAN;tr|M0R323|M0R323_HUMAN;tr|M0QZT2|M0QZT2_HUMAN",2450,"Q15102","PA1B3_HUMAN","Platelet-activating factor acetylhydrolase IB subunit gamma",null,"PAFAH1B3"]
["20.5698","21.1518","19.7594","20.0544",{"$nulls":4},"nucleic acid binding","nucleus",{"$nulls":3},6,6,6,37,37,37,"26.034",0,"20.546",138710000,15,"1.0009",1,"0.953879","2.92354","sp|O75391|SPAG7_HUMAN;tr|I3L0X5|I3L0X5_HUMAN;tr|I3L4C3|I3L4C3_HUMAN;tr|I3L0Q5|I3L0Q5_HUMAN","sp|O75391|SPAG7_HUMAN;tr|I3L0X5|I3L0X5_HUMAN;tr|I3L4C3|I3L4C3_HUMAN",561,"O75391","SPAG7_HUMAN","Sperm-associated antigen 7",null,"SPAG7"]
["20.5739","20.5247","20.8349","18.3579",{"$nulls":3},"carbohydrate metabolic process;isocitrate metabolic process;tricarboxylic acid cycle","ATP binding;isocitrate dehydrogenase (NAD+) activity;magnesium ion binding;NAD binding","mitochondrial matrix;mitochondrion;nucleolus;nucleoplasm","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways",null,null,4,4,4,"17.8","17.8","17.8","42.794",0,"37.941",208310000,21,"0.282169",1,"0.952847","0.769208","sp|P51553|IDH3G_HUMAN;tr|H7C1W2|H7C1W2_HUMAN;tr|E9PF84|E9PF84_HUMAN;tr|G5E9Q7|G5E9Q7_HUMAN;tr|E7EQB8|E7EQB8_HUMAN","sp|P51553|IDH3G_HUMAN;tr|H7C1W2|H7C1W2_HUMAN;tr|E9PF84|E9PF84_HUMAN;tr|G5E9Q7|G5E9Q7_HUMAN;tr|E7EQB8|E7EQB8_HUMAN",1654,"P51553","IDH3G_HUMAN","Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial",null,"IDH3G"]
["21.0242","21.0622","19.6353","20.5463",{"$nulls":3},"DNA-dependent DNA replication;mitochondrial respiratory chain complex assembly;mitochondrion organization;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase I promoter;transcription from mitochondrial promoter;transcription initiation from mitochondrial promoter","chromatin binding;DNA binding transcription factor activity;DNA binding, bending;heat shock protein binding;mitochondrial promoter sequence-specific DNA binding;RNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcription coactivator binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytosol;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleus","Apelin signaling pathway;Huntington disease",null,null,10,10,10,"28.9","28.9","28.9","29.096",0,"29.146",2224100000,124,"0.76466",1,"0.952377","2.0889","sp|Q00059|TFAM_HUMAN;tr|H7BYN3|H7BYN3_HUMAN","sp|Q00059|TFAM_HUMAN;tr|H7BYN3|H7BYN3_HUMAN",2026,"Q00059","TFAM_HUMAN","Transcription factor A, mitochondrial","tTFA","TFAM"]
["18.1729","17.4203","18.4132","15.2799",{"$nulls":3},"cellular response to insulin stimulus;insulin receptor signaling pathway via phosphatidylinositol 3-kinase;intracellular protein transmembrane transport;positive regulation of glucose import in response to insulin stimulus;positive regulation of glucose transport;positive regulation of protein targeting to membrane;positive regulation of vesicle fusion;protein localization to plasma membrane;vesicle fusion","calcium ion binding;calcium-dependent phospholipid binding","cell cortex;cytoplasmic vesicle membrane;cytosol;microtubule organizing center;plasma membrane;ruffle membrane",{"$nulls":3},22,22,17,"33.5","33.5","24.9","110.45",0,"138.95",1155300000,114,"0.211017",1,"0.950082","0.589672","sp|Q86YS7|C2CD5_HUMAN;tr|H0YFE9|H0YFE9_HUMAN;tr|H0YGU7|H0YGU7_HUMAN","sp|Q86YS7|C2CD5_HUMAN",3096,"Q86YS7","C2CD5_HUMAN","C2 domain-containing protein 5",null,"C2CD5"]
["17.3088","19.2562","17.2363","17.4295",{"$nulls":5},"nucleus",{"$nulls":3},23,23,21,"35.6","35.6","31.2","94.868",0,"96.874",1548100000,179,"0.362349",1,"0.949612","0.97053","sp|Q6PCB5|RSBNL_HUMAN;tr|A0A087X239|A0A087X239_HUMAN;tr|C9JM20|C9JM20_HUMAN;tr|H7C2D3|H7C2D3_HUMAN","sp|Q6PCB5|RSBNL_HUMAN;tr|A0A087X239|A0A087X239_HUMAN",2875,"Q6PCB5","RSBNL_HUMAN","Round spermatid basic protein 1-like protein",null,"RSBN1L"]
["18.8863","19.0778","18.4896","17.5775",{"$nulls":4},"cysteine-type endopeptidase activity",{"$nulls":4},1,1,1,"10.4","10.4","10.4","24.79","0.00024534","5.8986",47591000,11,"0.74778",1,"0.948524","2.03563","tr|Q5SVL2|Q5SVL2_HUMAN;sp|P55210|CASP7_HUMAN;tr|A0A0A0MRL7|A0A0A0MRL7_HUMAN","tr|Q5SVL2|Q5SVL2_HUMAN;sp|P55210|CASP7_HUMAN;tr|A0A0A0MRL7|A0A0A0MRL7_HUMAN",1762,"Q5SVL2","Q5SVL2_HUMAN",null,null,"CASP7"]
["17.0639","16.5524","17.0255","14.7033",{"$nulls":3},"actin modification;barbed-end actin filament capping;cell cycle;cell division;positive regulation of substrate adhesion-dependent cell spreading","actin filament binding;GTP-Rho binding;myosin II binding;ubiquitin protein ligase binding","actin cytoskeleton;cytoplasm;focal adhesion;microtubule organizing center;midbody;nucleus",{"$nulls":3},23,23,22,"10.2","10.2","10.2","261.37",0,"87.304",1155500000,111,"0.291967",1,"0.943771","0.793777","sp|Q9H2D6|TARA_HUMAN;tr|F6WYE2|F6WYE2_HUMAN;tr|H0Y5J9|H0Y5J9_HUMAN;tr|F6TR96|F6TR96_HUMAN;tr|F6WMF4|F6WMF4_HUMAN","sp|Q9H2D6|TARA_HUMAN;tr|F6WYE2|F6WYE2_HUMAN",4167,"Q9H2D6","TARA_HUMAN","TRIO and F-actin-binding protein",null,"TRIOBP"]
["20.3166","20.2173","19.0043","19.647",{"$nulls":3},"cell division;mitotic chromosome condensation",null,"condensed chromosome, centromeric region;condensin complex;cytoplasm;cytosol;membrane;nucleus",{"$nulls":3},11,11,11,"14.7","14.7","14.7","114.33",0,"63.056",444030000,45,"0.99362",1,"0.941331","2.89498","sp|Q9BPX3|CND3_HUMAN;tr|D6RA93|D6RA93_HUMAN;tr|H0Y9Z8|H0Y9Z8_HUMAN","sp|Q9BPX3|CND3_HUMAN",3902,"Q9BPX3","CND3_HUMAN","Condensin complex subunit 3",null,"NCAPG"]
["23.5188","21.3773","23.5776","19.4363",{"$nulls":3},"mRNA splicing, via spliceosome;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA processing","pre-mRNA intronic binding;RNA binding;transcription regulatory region DNA binding","cytoplasm;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus;ribonucleoprotein granule",{"$nulls":3},19,19,10,"50.4","50.4","32.1","64.132",0,"139.02",1436800000,88,"0.139365",1,"0.941102","0.403717","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN;tr|M0R1W6|M0R1W6_HUMAN;tr|M0QYL7|M0QYL7_HUMAN;tr|B4DVF8|B4DVF8_HUMAN","sp|P14866|HNRPL_HUMAN;tr|M0QXS5|M0QXS5_HUMAN",1052,"P14866","HNRPL_HUMAN","Heterogeneous nuclear ribonucleoprotein L","nRNP L","HNRNPL"]
["16.7374","17.3479","15.4892","16.7183",{"$nulls":3},"cell-cell signaling;homophilic cell adhesion via plasma membrane adhesion molecules;nervous system development","calcium ion binding","cell junction;cell-cell junction;integral component of plasma membrane;intracellular membrane-bounded organelle;nucleolus;nucleus;plasma membrane",{"$nulls":3},8,8,8,"11.2","11.2","11.2","114.74",0,"22.928",84434000,13,"0.516212",1,"0.938958","1.36836","sp|Q08174|PCDH1_HUMAN;tr|D6RAX3|D6RAX3_HUMAN;tr|H0Y9F5|H0Y9F5_HUMAN;tr|D6RBG2|D6RBG2_HUMAN","sp|Q08174|PCDH1_HUMAN",2124,"Q08174","PCDH1_HUMAN","Protocadherin-1",null,"PCDH1"]
[1,"18.5302",1,"16.6611",{"$nulls":9},2,2,2,"4.7","4.7","4.7","73.281","0.0065528","2.6038",17037000,1,"0.0250905",1,"0.93456","0.0795134","tr|G3V195|G3V195_HUMAN;sp|Q32P44|EMAL3_HUMAN;tr|B7WPE2|B7WPE2_HUMAN;tr|H7C355|H7C355_HUMAN;tr|G3V1D0|G3V1D0_HUMAN;tr|H0Y3M3|H0Y3M3_HUMAN","tr|G3V195|G3V195_HUMAN;sp|Q32P44|EMAL3_HUMAN;tr|B7WPE2|B7WPE2_HUMAN;tr|H7C355|H7C355_HUMAN;tr|G3V1D0|G3V1D0_HUMAN;tr|H0Y3M3|H0Y3M3_HUMAN",2611,"G3V195","G3V195_HUMAN"]
["23.1202","21.419","23.1859","19.4897",{"$nulls":3},"mRNA splicing, via spliceosome;RNA metabolic process","RNA binding","catalytic step 2 spliceosome;intracellular ribonucleoprotein complex;nucleoplasm;nucleus","Spliceosome",null,null,11,11,11,"31.5","31.5","31.5","39.594",0,"66.828",953670000,57,"0.159956",1,"0.93178","0.457996","sp|P51991|ROA3_HUMAN;tr|H7C1J8|H7C1J8_HUMAN","sp|P51991|ROA3_HUMAN",1677,"P51991","ROA3_HUMAN","Heterogeneous nuclear ribonucleoprotein A3","nRNP A3","HNRNPA3"]
["19.8811","19.8666","20.0204","17.8648",{"$nulls":3},"protein depalmitoylation","carboxylic ester hydrolase activity;lysophospholipase activity;palmitoyl-(protein) hydrolase activity","cytoplasm;cytosol;extracellular exosome",{"$nulls":3},6,6,6,"30.4","30.4","30.4","26.316",0,"10.509",114500000,8,"0.319975",1,"0.931214","0.863997","sp|Q5VWZ2|LYPL1_HUMAN","sp|Q5VWZ2|LYPL1_HUMAN",2766,"Q5VWZ2","LYPL1_HUMAN","Lysophospholipase-like protein 1",null,"LYPLAL1"]
["21.1612","18.7629","21.2437","16.8195",{"$nulls":3},"epithelial cell differentiation;mRNA splicing, via spliceosome;RNA processing;RNA splicing","RNA binding","nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},5,5,5,"21.4","21.4","21.4","36.926",0,"61.206",237410000,14,"0.126666",1,"0.930465","0.369791","sp|P31942|HNRH3_HUMAN","sp|P31942|HNRH3_HUMAN",1338,"P31942","HNRH3_HUMAN","Heterogeneous nuclear ribonucleoprotein H3","nRNP H3","HNRNPH3"]
["15.4309","16.7695","15.0443","15.3083",{"$nulls":3},"positive regulation of proteasomal protein catabolic process;response to endoplasmic reticulum stress",null,"endoplasmic reticulum;integral component of membrane",{"$nulls":3},5,5,5,"6.8","6.8","6.8","104.01",0,"14.132",98432000,17,"0.510929",1,"0.923896","1.35426","sp|Q6ZXV5|TMTC3_HUMAN;tr|F8VRY4|F8VRY4_HUMAN","sp|Q6ZXV5|TMTC3_HUMAN",2939,"Q6ZXV5","TMTC3_HUMAN","Transmembrane and TPR repeat-containing protein 3",null,"TMTC3"]
["16.807","16.7876","16.558","15.1929",{"$nulls":3},"Golgi apparatus mannose trimming;N-glycan processing;protein glycosylation","calcium ion binding;mannosidase activity;mannosyl-oligosaccharide 1,2-alpha-mannosidase activity","cytosol;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of membrane;membrane","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,4,4,4,"8.4","8.4","8.4","72.968","0.00024716","6.1529",26255000,3,"0.50952",1,"0.921865","1.3505","sp|P33908|MA1A1_HUMAN","sp|P33908|MA1A1_HUMAN",1359,"P33908","MA1A1_HUMAN","Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA",null,"MAN1A1"]
["18.8709","18.799","18.976","16.8549",{"$nulls":3},"positive regulation of protein binding;positive regulation of protein localization to nucleolus;positive regulation of RNA biosynthetic process;ribosomal large subunit export from nucleus","protein binding, bridging;ribosomal large subunit binding;RNA binding","cytoplasm;membrane;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes;RNA transport",null,null,4,4,4,"13.9","13.9","13.9","57.603",0,"16.859",123110000,13,"0.320972",1,"0.919497","0.866497","sp|Q96D46|NMD3_HUMAN;tr|C9JA08|C9JA08_HUMAN;tr|C9J0B9|C9J0B9_HUMAN","sp|Q96D46|NMD3_HUMAN;tr|C9JA08|C9JA08_HUMAN",3645,"Q96D46","NMD3_HUMAN","60S ribosomal export protein NMD3","NMD3","NMD3"]
["22.017","24.0962","22.3522","21.9262",{"$nulls":3},"cargo loading into vesicle;COPI coating of Golgi vesicle;COPII vesicle coating;ER to Golgi vesicle-mediated transport;Golgi organization;heart looping;intracellular protein transport;labyrinthine layer blood vessel development;maternal placenta development;multicellular organism growth;negative regulation of GTPase activity;neural tube closure;positive regulation of gene expression;post-anal tail morphogenesis;protein localization to plasma membrane;retrograde vesicle-mediated transport, Golgi to ER;somite rostral/caudal axis specification",null,"COPI-coated vesicle;COPI-coated vesicle membrane;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;integral component of membrane;intracellular membrane-bounded organelle;transport vesicle;zymogen granule membrane",{"$nulls":3},4,4,4,"30.8","30.8","30.8","22.761",0,"42.557",530600000,44,"0.320195",1,"0.917439","0.864548","sp|Q15363|TMED2_HUMAN;tr|F5GX39|F5GX39_HUMAN;tr|E7EQ72|E7EQ72_HUMAN","sp|Q15363|TMED2_HUMAN;tr|F5GX39|F5GX39_HUMAN;tr|E7EQ72|E7EQ72_HUMAN",2474,"Q15363","TMED2_HUMAN","Transmembrane emp24 domain-containing protein 2",null,"TMED2"]
["21.0381","20.9826","21.2032","18.9915",{"$nulls":3},"oxidation-reduction process",null,"mitochondrial inner membrane;respiratory chain",{"$nulls":3},5,5,5,"35.2","35.2","35.2","15.136",0,"13.916",284670000,43,"0.304551",1,"0.912971","0.825323","tr|A0A0C4DGS0|A0A0C4DGS0_HUMAN;sp|P56556|NDUA6_HUMAN;tr|R4GN43|R4GN43_HUMAN","tr|A0A0C4DGS0|A0A0C4DGS0_HUMAN;sp|P56556|NDUA6_HUMAN;tr|R4GN43|R4GN43_HUMAN",1785,"A0A0C4DGS0","A0A0C4DGS0_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 {ECO:0000256|PIRNR:PIRNR006643}",null,"NDUFA6"]
["15.2293","15.3311","13.7281","15.0067",{"$nulls":3},"positive regulation by host of viral genome replication;response to interleukin-1;response to tumor necrosis factor;RNA processing","ATP binding;ATP-dependent RNA helicase activity;N6-methyladenosine-containing RNA binding;RNA binding;RNA polymerase binding;RNA-dependent ATPase activity","endoplasmic reticulum",{"$nulls":3},4,4,4,"3.3","3.3","3.3","160.25","0.00024438","5.8287",29231000,7,"0.536667",1,"0.912776","1.42333","sp|Q9H6S0|YTDC2_HUMAN;tr|D6RF50|D6RF50_HUMAN;tr|D6RA70|D6RA70_HUMAN","sp|Q9H6S0|YTDC2_HUMAN",4230,"Q9H6S0","YTDC2_HUMAN","Probable ATP-dependent RNA helicase YTHDC2",null,"YTHDC2"]
["21.1515","21.2735","21.3664","19.2364",{"$nulls":9},2,2,2,"42.1","42.1","42.1","6.3823","0.00024969","6.3442",54454000,10,"0.316032",1,"0.91111","0.854107","tr|H3BUW6|H3BUW6_HUMAN;tr|H3BN64|H3BN64_HUMAN;tr|H3BRM1|H3BRM1_HUMAN;tr|H3BRF9|H3BRF9_HUMAN;sp|Q96K21|ANCHR_HUMAN","tr|H3BUW6|H3BUW6_HUMAN;tr|H3BN64|H3BN64_HUMAN;tr|H3BRM1|H3BRM1_HUMAN;tr|H3BRF9|H3BRF9_HUMAN;sp|Q96K21|ANCHR_HUMAN",3751,"H3BUW6","H3BUW6_HUMAN",null,null,"ZFYVE19"]
["18.1202","15.7181","16.6085","15.4113",{"$nulls":3},"negative regulation of transcription, DNA-templated",{"$nulls":5},6,5,4,"51.9","47.1","43.8","22.81",0,"25.669",215560000,32,"0.245706",1,"0.909248","0.677548","sp|Q4VC05|BCL7A_HUMAN;tr|F8WE18|F8WE18_HUMAN;tr|F8WDZ4|F8WDZ4_HUMAN","sp|Q4VC05|BCL7A_HUMAN",2636,"Q4VC05","BCL7A_HUMAN","B-cell CLL/lymphoma 7 protein family member A",null,"BCL7A"]
["20.4687","19.7107","19.6605","18.7032",{"$nulls":3},"COPII-coated vesicle budding;intracellular protein transport","zinc ion binding","COPII vesicle coat;cytosol;endomembrane system;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane;perinuclear region of cytoplasm","Protein processing in endoplasmic reticulum",null,null,13,11,11,"22.9","20.1","20.1","86.478",0,"51.483",426050000,32,"0.560004",1,"0.907828","1.48683","sp|Q15437|SC23B_HUMAN;tr|Q5QPE1|Q5QPE1_HUMAN;tr|Q5QPE2|Q5QPE2_HUMAN","sp|Q15437|SC23B_HUMAN;tr|Q5QPE1|Q5QPE1_HUMAN",2493,"Q15437","SC23B_HUMAN","Protein transport protein Sec23B {ECO:0000305}","Sec23B {ECO:0000303|PubMed:8898360}","SEC23B"]
["19.1946","19.4654","19.2694","17.5815",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosomal small subunit biogenesis;rRNA base methylation;rRNA processing","RNA binding;rRNA (pseudouridine) methyltransferase activity;rRNA binding","cytoplasm;nucleolus;nucleoplasm;nucleus;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,2,2,2,"9.8","9.8","9.8","26.72","0.0037329","3.1249",63664000,3,"0.396993",1,"0.904558","1.05825","sp|Q92979|NEP1_HUMAN;tr|V9GYP5|V9GYP5_HUMAN;tr|A0A087WWQ2|A0A087WWQ2_HUMAN","sp|Q92979|NEP1_HUMAN;tr|V9GYP5|V9GYP5_HUMAN;tr|A0A087WWQ2|A0A087WWQ2_HUMAN",3562,"Q92979","NEP1_HUMAN","Ribosomal RNA small subunit methyltransferase NEP1 {ECO:0000305|PubMed:20047967}",null,"EMG1"]
["18.3016","17.8004","17.6616","16.6347",{"$nulls":3},"mRNA splicing, via spliceosome;RNA splicing","ATP binding;ATPase activity;ATP-dependent RNA helicase activity;RNA binding;RNA helicase activity","cytoplasm;nucleoplasm;nucleus;spliceosomal complex","Spliceosome",null,null,14,14,14,"18.6","18.6","18.6","119.26",0,"61.581",388500000,75,"0.593748",1,"0.902861","1.58025","sp|O60231|DHX16_HUMAN;tr|Q5SQH5|Q5SQH5_HUMAN;tr|A2AB15|A2AB15_HUMAN","sp|O60231|DHX16_HUMAN",456,"O60231","DHX16_HUMAN","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16",null,"DHX16"]
["18.1489","19.459","18.2369","17.5752",{"$nulls":3},"prolyl-tRNA aminoacylation","ATP binding;proline-tRNA ligase activity","mitochondrial matrix","Aminoacyl-tRNA biosynthesis",null,null,3,3,3,"10.5","10.5","10.5","53.262",0,"10.113",127790000,12,"0.461303",1,"0.897953","1.22359","sp|Q7L3T8|SYPM_HUMAN","sp|Q7L3T8|SYPM_HUMAN",2966,"Q7L3T8","SYPM_HUMAN","Probable proline--tRNA ligase, mitochondrial",null,"PARS2"]
[1,"18.8705",1,"17.0748",{"$nulls":3},"post-translational protein modification","kinase activity","cytosol",{"$nulls":3},4,4,4,"19.7","19.7","19.7","34.412","0.002927","3.2389",19013000,3,"0.0235365",1,"0.897854","0.0747073","sp|Q9HA64|KT3K_HUMAN;tr|I3L2G3|I3L2G3_HUMAN;tr|I3L139|I3L139_HUMAN;tr|I3L3W5|I3L3W5_HUMAN;tr|I3L378|I3L378_HUMAN","sp|Q9HA64|KT3K_HUMAN;tr|I3L2G3|I3L2G3_HUMAN;tr|I3L139|I3L139_HUMAN",4285,"Q9HA64","KT3K_HUMAN","Ketosamine-3-kinase",null,"FN3KRP"]
["17.5698","18.6782","17.505","16.9524",{"$nulls":3},"glucose homeostasis;peptidyl-lysine modification to peptidyl-hypusine;positive regulation of cell proliferation;positive regulation of T cell proliferation;protein homotetramerization;spermidine catabolic process;spermidine metabolic process;translation","deoxyhypusine synthase activity;identical protein binding","cytoplasm;cytosol",{"$nulls":3},4,4,4,"15.4","15.4","15.4","40.97",0,"13.961",34600000,6,"0.544926",1,"0.895256","1.4457","sp|P49366|DHYS_HUMAN;tr|A0A087WZK0|A0A087WZK0_HUMAN;tr|Q5J8M5|Q5J8M5_HUMAN;tr|M0R1T2|M0R1T2_HUMAN;tr|M0R0V2|M0R0V2_HUMAN;tr|M0R264|M0R264_HUMAN;tr|M0R1T4|M0R1T4_HUMAN;tr|M0R253|M0R253_HUMAN;tr|M0QX43|M0QX43_HUMAN;tr|B4E3M2|B4E3M2_HUMAN","sp|P49366|DHYS_HUMAN;tr|A0A087WZK0|A0A087WZK0_HUMAN;tr|Q5J8M5|Q5J8M5_HUMAN;tr|M0R1T2|M0R1T2_HUMAN;tr|M0R0V2|M0R0V2_HUMAN;tr|M0R264|M0R264_HUMAN",1568,"P49366","DHYS_HUMAN","Deoxyhypusine synthase","HS","DHPS"]
["20.6579","20.5031","20.4677","18.904",{"$nulls":4},"RNA binding","membrane;nucleoplasm;nucleus",{"$nulls":3},17,17,17,"28.8","28.8","28.8","85.104",0,"64.12",541910000,54,"0.428456",1,"0.894637","1.13866","sp|Q1KMD3|HNRL2_HUMAN;tr|H3BQZ7|H3BQZ7_HUMAN","sp|Q1KMD3|HNRL2_HUMAN;tr|H3BQZ7|H3BQZ7_HUMAN",2586,"Q1KMD3","HNRL2_HUMAN","Heterogeneous nuclear ribonucleoprotein U-like protein 2",null,"HNRNPUL2"]
["21.9915","22.3709","22.1837","20.3896",{"$nulls":3},"negative regulation of mitochondrial membrane potential;neutrophil degranulation;positive regulation of mitochondrial membrane permeability;positive regulation of necrotic cell death",null,"azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;mitochondrion",{"$nulls":3},7,7,7,"44.9","44.9","44.9","22.875",0,"38.942",327110000,14,"0.364389",1,"0.894561","0.975675","sp|Q9Y5Z4|HEBP2_HUMAN;tr|Q5THN1|Q5THN1_HUMAN;tr|C9IZA0|C9IZA0_HUMAN","sp|Q9Y5Z4|HEBP2_HUMAN",5067,"Q9Y5Z4","HEBP2_HUMAN","Heme-binding protein 2",null,"HEBP2"]
["19.9553","20.472","18.491","20.1521",{"$nulls":9},4,4,4,"39.1","39.1","39.1","12.405","0.00025988","7.2025",88164000,9,"0.38413",1,"0.892107","1.0256","tr|E9PN51|E9PN51_HUMAN;tr|F8W9K7|F8W9K7_HUMAN;tr|E9PPW7|E9PPW7_HUMAN;sp|O00217|NDUS8_HUMAN;tr|E9PKH6|E9PKH6_HUMAN","tr|E9PN51|E9PN51_HUMAN;tr|F8W9K7|F8W9K7_HUMAN;tr|E9PPW7|E9PPW7_HUMAN;sp|O00217|NDUS8_HUMAN;tr|E9PKH6|E9PKH6_HUMAN",202,"E9PN51","E9PN51_HUMAN",null,null,"NDUFS8"]
["16.6621",1,"14.8786",1,{"$nulls":3},"snRNA transcription from RNA polymerase II promoter",null,"DNA-directed RNA polymerase II, holoenzyme;nucleoplasm",{"$nulls":3},3,3,3,4,4,4,"156.02","0.00068182","4.3911",31794000,4,"0.0269437",1,"0.891739","0.0852261","sp|Q5VT52|RPRD2_HUMAN","sp|Q5VT52|RPRD2_HUMAN",2755,"Q5VT52","RPRD2_HUMAN","Regulation of nuclear pre-mRNA domain-containing protein 2",null,"RPRD2"]
["20.5543","20.3954","20.544","18.6292",{"$nulls":3},"negative regulation of transcription, DNA-templated;positive regulation of abscisic acid-activated signaling pathway","ATP binding;GTP binding;phosphatidylinositol-3-phosphate binding;phosphatidylinositol-4-phosphate binding;phosphatidylinositol-5-phosphate binding","cortical actin cytoskeleton;cytosol;nucleus;plasma membrane",{"$nulls":3},10,10,10,"25.6","25.6","25.6","50.854",0,"34.34",377050000,31,"0.344124",1,"0.88829","0.924634","sp|Q9NS86|LANC2_HUMAN","sp|Q9NS86|LANC2_HUMAN",4436,"Q9NS86","LANC2_HUMAN","LanC-like protein 2",null,"LANCL2"]
["17.384","19.4626","17.598","17.4722",{"$nulls":3},"box H/ACA snoRNA 3'-end processing;cell proliferation;mRNA pseudouridine synthesis;positive regulation of establishment of protein localization to telomere;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;regulation of telomerase RNA localization to Cajal body;RNA processing;rRNA processing;rRNA pseudouridine synthesis;snRNA pseudouridine synthesis;telomerase RNA stabilization;telomere maintenance via telomerase","box H/ACA snoRNA binding;pseudouridine synthase activity;RNA binding;telomerase activity;telomerase RNA binding","box H/ACA scaRNP complex;box H/ACA snoRNP complex;box H/ACA telomerase RNP complex;cytoplasm;fibrillar center;nucleolus;nucleoplasm;nucleus;telomerase holoenzyme complex","Ribosome biogenesis in eukaryotes",null,null,15,15,15,35,35,35,"57.673",0,"46.814",974440000,91,"0.315615",1,"0.888221","0.853062","sp|O60832|DKC1_HUMAN;tr|C9IYT0|C9IYT0_HUMAN;tr|H7C0M1|H7C0M1_HUMAN;tr|H7C2Q9|H7C2Q9_HUMAN;tr|H7BZF2|H7BZF2_HUMAN","sp|O60832|DKC1_HUMAN;tr|C9IYT0|C9IYT0_HUMAN",508,"O60832","DKC1_HUMAN","H/ACA ribonucleoprotein complex subunit 4",null,"DKC1"]
["21.9551","22.7704","22.2699","20.6816",{"$nulls":4},"nucleosomal DNA binding","chromatin;nucleus",{"$nulls":3},7,7,7,"60.1","60.1","60.1","16.496",0,"75.533",323820000,35,"0.371537",1,"0.887065","0.993724","tr|Q5JSL0|Q5JSL0_HUMAN;tr|Q5JSK6|Q5JSK6_HUMAN;sp|P82970|HMGN5_HUMAN;tr|Q5JSK9|Q5JSK9_HUMAN;tr|Q5JSK7|Q5JSK7_HUMAN;tr|Q5JSK8|Q5JSK8_HUMAN","tr|Q5JSL0|Q5JSL0_HUMAN;tr|Q5JSK6|Q5JSK6_HUMAN;sp|P82970|HMGN5_HUMAN;tr|Q5JSK9|Q5JSK9_HUMAN;tr|Q5JSK7|Q5JSK7_HUMAN;tr|Q5JSK8|Q5JSK8_HUMAN",2000,"Q5JSL0","Q5JSL0_HUMAN",null,null,"HMGN5"]
["19.6337","18.3143","19.5694","16.6062",{"$nulls":3},"mitotic cell cycle;mitotic spindle assembly checkpoint;mRNA processing;protein localization to kinetochore;RNA splicing;viral process","identical protein binding","chromosome;cytoplasm;nuclear speck;nucleoplasm;spindle pole;spliceosomal complex",{"$nulls":3},16,16,16,"32.1","32.1","32.1","65.601",0,"172.94",1007700000,97,"0.194091",1,"0.886171","0.5464","sp|Q13123|RED_HUMAN;tr|E7EQZ7|E7EQZ7_HUMAN;tr|Q9H4P6|Q9H4P6_HUMAN;tr|D6REL4|D6REL4_HUMAN;tr|D6RAY9|D6RAY9_HUMAN;tr|D6RCQ4|D6RCQ4_HUMAN;tr|A0A0C4DGW5|A0A0C4DGW5_HUMAN","sp|Q13123|RED_HUMAN;tr|E7EQZ7|E7EQZ7_HUMAN;tr|Q9H4P6|Q9H4P6_HUMAN;tr|D6REL4|D6REL4_HUMAN",2205,"Q13123","RED_HUMAN","Protein Red {ECO:0000303|PubMed:10216252}",null,"IK"]
["20.4909","21.2724","20.3265","19.6859",{"$nulls":3},"cellular aldehyde metabolic process;xenobiotic metabolic process","aldo-keto reductase (NADP) activity;electron transfer activity;identical protein binding","cytosol;extracellular exosome","Metabolism of xenobiotics by cytochrome P450",null,null,6,5,4,"24.2","20.8","17.2","37.206",0,"11.993",176940000,11,"0.647261",1,"0.875432","1.73269","sp|O95154|ARK73_HUMAN","sp|O95154|ARK73_HUMAN",694,"O95154","ARK73_HUMAN","Aflatoxin B1 aldehyde reductase member 3",null,"AKR7A3"]
["16.8809","20.3752","16.6049","18.9027",{"$nulls":9},4,4,4,"21.1","21.1","21.1","18.66",0,"9.2694",73652000,9,"0.144789",1,"0.874253","0.418097","tr|Q5QPM0|Q5QPM0_HUMAN;tr|Q5QPL9|Q5QPL9_HUMAN;sp|Q9UKM9|RALY_HUMAN;tr|Q5QPM1|Q5QPM1_HUMAN;tr|Q5QPM2|Q5QPM2_HUMAN","tr|Q5QPM0|Q5QPM0_HUMAN;tr|Q5QPL9|Q5QPL9_HUMAN;sp|Q9UKM9|RALY_HUMAN;tr|Q5QPM1|Q5QPM1_HUMAN",4789,"Q5QPM0","Q5QPM0_HUMAN",null,null,"RALY"]
["16.7988","16.7466","16.8374","14.9656",{"$nulls":3},"regulation of small GTPase mediated signal transduction;small GTPase mediated signal transduction","GTPase activator activity;phosphatidylinositol binding","actin cytoskeleton;cell cortex;cell junction;cytosol;dendritic spine;endoplasmic reticulum membrane;endosome membrane;fibrillar center;Golgi apparatus;Golgi membrane;nucleoplasm;postsynaptic density;postsynaptic membrane",{"$nulls":3},15,15,15,"12.4","12.4","12.4","230.53",0,"65.069",333740000,44,"0.34647",1,"0.871196","0.930536","sp|A7KAX9|RHG32_HUMAN;tr|G3V174|G3V174_HUMAN;tr|K7EQI6|K7EQI6_HUMAN;tr|A0A0A0MQQ9|A0A0A0MQQ9_HUMAN;tr|K7EMC2|K7EMC2_HUMAN;sp|O14559|RHG33_HUMAN","sp|A7KAX9|RHG32_HUMAN",175,"A7KAX9","RHG32_HUMAN","Rho GTPase-activating protein 32",null,"ARHGAP32"]
["21.9486","22.0155","22.2624","19.9634",{"$nulls":3},"apoptotic process;cellular response to staurosporine;epithelial cell differentiation;execution phase of apoptosis;proteolysis;regulation of apoptotic process","cysteine-type endopeptidase activity;cysteine-type endopeptidase activity involved in execution phase of apoptosis;cysteine-type peptidase activity;identical protein binding","cytosol;nucleoplasm","Apoptosis",null,null,8,8,8,"31.7","31.7","31.7","33.31",0,"46.411",480020000,32,"0.276835",1,"0.869177","0.755824","sp|P55212|CASP6_HUMAN;tr|D6RHU3|D6RHU3_HUMAN;tr|D6RBM3|D6RBM3_HUMAN","sp|P55212|CASP6_HUMAN;tr|D6RHU3|D6RHU3_HUMAN",1763,"P55212","CASP6_HUMAN","Caspase-6","ASP-6","CASP6"]
["20.1071","20.8913","20.288","18.9754",{"$nulls":3},"regulation of double-strand break repair via homologous recombination","metal ion binding;NF-kappaB-inducing kinase activity;protein serine/threonine phosphatase activity","cytosol;microtubule organizing center;nucleoplasm;nucleus;plasma membrane;protein phosphatase 4 complex","Glucagon signaling pathway",null,null,6,6,6,"21.8","21.8","21.8","35.08",0,"11.86",145540000,8,"0.426908",1,"0.867498","1.13469","sp|P60510|PP4C_HUMAN;tr|H3BTA2|H3BTA2_HUMAN;tr|I3L4X0|I3L4X0_HUMAN;tr|H3BV22|H3BV22_HUMAN;tr|H3BPN5|H3BPN5_HUMAN;tr|H3BVE3|H3BVE3_HUMAN","sp|P60510|PP4C_HUMAN;tr|H3BTA2|H3BTA2_HUMAN;tr|I3L4X0|I3L4X0_HUMAN;tr|H3BV22|H3BV22_HUMAN",1808,"P60510","PP4C_HUMAN","Serine/threonine-protein phosphatase 4 catalytic subunit","p4;P4C","PPP4C"]
["19.9121","21.0369","20.0474","19.1696",{"$nulls":3},"interleukin-12-mediated signaling pathway","phospholipase binding;structural molecule activity","lamin filament;membrane;nuclear envelope;nuclear inner membrane;nuclear matrix;nuclear membrane;nucleoplasm;nucleus","Apoptosis",null,null,26,25,24,"48.6","48.6","46.9","66.408",0,"165.29",896480000,95,"0.457565",1,"0.865999","1.21387","sp|P20700|LMNB1_HUMAN;tr|E9PBF6|E9PBF6_HUMAN;tr|A0A0D9SFE5|A0A0D9SFE5_HUMAN;tr|A0A0D9SFY5|A0A0D9SFY5_HUMAN","sp|P20700|LMNB1_HUMAN;tr|E9PBF6|E9PBF6_HUMAN;tr|A0A0D9SFE5|A0A0D9SFE5_HUMAN",1153,"P20700","LMNB1_HUMAN","Lamin-B1",null,"LMNB1"]
["18.5032","18.0773","17.3784","17.4705",{"$nulls":3},"cilium assembly;multicellular organism development;positive regulation of cell motility;positive regulation of feeding behavior;protein polyglutamylation;regulation of cilium beat frequency involved in ciliary motility","RNA binding","centriole;ciliary basal body;cilium;extracellular exosome;microtubule;nucleus",{"$nulls":3},4,4,4,"19.7","19.7","19.7","22.774",0,"9.5187",146270000,17,"1.23757",1,"0.865827","3.9744","sp|Q9Y6A4|CFA20_HUMAN;tr|H3BPA3|H3BPA3_HUMAN","sp|Q9Y6A4|CFA20_HUMAN",5083,"Q9Y6A4","CFA20_HUMAN","Cilia- and flagella-associated protein 20",null,"CFAP20"]
["18.9342","18.6247","18.6341","17.194",{"$nulls":3},"negative regulation of chromatin binding;negative regulation of transcription from RNA polymerase II promoter;positive regulation of G1/S transition of mitotic cell cycle;RNA methylation;snRNA metabolic process;snRNA modification","RNA binding;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity",{"$nulls":4},6,6,6,"14.4","14.4","14.4","74.354",0,"34.335",105280000,21,"0.44258",1,"0.865391","1.17505","sp|Q7L2J0|MEPCE_HUMAN","sp|Q7L2J0|MEPCE_HUMAN",2964,"Q7L2J0","MEPCE_HUMAN","7SK snRNA methylphosphate capping enzyme","ePCE","MEPCE"]
["17.3808",1,1,"15.658",{"$nulls":3},"negative regulation of protein kinase activity;regulation of transcription, DNA-templated;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","DNA binding","cytosol;fibrillar center;nucleoplasm;nucleus;transcription elongation factor complex","Transcriptional misregulation in cancer",null,null,7,7,7,"23.1","23.1","23.1","62.055",0,"19.273",340330000,30,"0.0247212",1,"0.861375","0.0783727","sp|Q03111|ENL_HUMAN","sp|Q03111|ENL_HUMAN",2078,"Q03111","ENL_HUMAN","Protein ENL",null,"MLLT1"]
["19.4021","21.2842","19.9916","18.9745",{"$nulls":3},"glutathione derivative biosynthetic process;leukotriene biosynthetic process;lipid metabolic process;response to organonitrogen compound;xenobiotic metabolic process","glutathione peroxidase activity;glutathione transferase activity;leukotriene-C4 synthase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;intracellular membrane-bounded organelle;membrane;nuclear envelope;organelle membrane","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Fluid shear stress and atherosclerosis;Glutathione metabolism;Hepatocellular carcinoma;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pathways in cancer;Platinum drug resistance",null,null,3,3,3,"32.2","32.2","32.2","16.516",0,"18.161",494870000,52,"0.296067",1,"0.860075","0.804056","sp|O14880|MGST3_HUMAN;tr|Q5VV89|Q5VV89_HUMAN;tr|Q5VV87|Q5VV87_HUMAN","sp|O14880|MGST3_HUMAN;tr|Q5VV89|Q5VV89_HUMAN;tr|Q5VV87|Q5VV87_HUMAN",294,"O14880","MGST3_HUMAN","Microsomal glutathione S-transferase 3","icrosomal GST-3","MGST3"]
["20.0135","19.8372","19.7909","18.3429",{"$nulls":3},"innate immune response;mitochondrial respiratory chain complex I assembly;regulation of oxidoreductase activity","oxidoreductase activity, acting on NAD(P)H","cytoplasm;cytosol;mitochondrial inner membrane;mitochondrion;nucleoplasm;nucleus","MAPK signaling pathway",null,null,4,4,4,"19.3","19.3","19.3","49.148",0,"13.663",164870000,22,"0.443346",1,"0.858436","1.17703","sp|Q9BQ95|ECSIT_HUMAN;tr|J3KTF5|J3KTF5_HUMAN;tr|K7EPL5|K7EPL5_HUMAN;tr|K7EN32|K7EN32_HUMAN","sp|Q9BQ95|ECSIT_HUMAN;tr|J3KTF5|J3KTF5_HUMAN",3914,"Q9BQ95","ECSIT_HUMAN","Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial",null,"ECSIT"]
["19.9436","16.3705","19.927","14.6793",{"$nulls":3},"apoptotic process;cell cycle;mRNA splicing, via spliceosome;positive regulation of cell migration;positive regulation of cell proliferation;regulation of transcription, DNA-templated;transcription, DNA-templated","core promoter binding;ligand-dependent nuclear receptor transcription coactivator activity;RNA binding;transcription coactivator activity;transcription corepressor activity","nucleoplasm;perinuclear region of cytoplasm",{"$nulls":3},10,10,10,"11.1","11.1","11.1","132.82",0,"32.208",254120000,26,"0.0898403",1,"0.853943","0.269014","sp|Q8IX12|CCAR1_HUMAN;tr|A0A0C4DGG8|A0A0C4DGG8_HUMAN;tr|F5H2E6|F5H2E6_HUMAN;tr|F5H1H2|F5H1H2_HUMAN;tr|F5H3E1|F5H3E1_HUMAN;tr|H0YFJ7|H0YFJ7_HUMAN","sp|Q8IX12|CCAR1_HUMAN;tr|A0A0C4DGG8|A0A0C4DGG8_HUMAN;tr|F5H2E6|F5H2E6_HUMAN;tr|F5H1H2|F5H1H2_HUMAN",3142,"Q8IX12","CCAR1_HUMAN","Cell division cycle and apoptosis regulator protein 1",null,"CCAR1"]
[1,"19.0227",1,"17.3175",{"$nulls":4},"methyltransferase activity","mitochondrion",{"$nulls":3},3,3,3,"16.1","16.1","16.1","25.414","0.00069589","4.8097",14087000,1,"0.0220631",1,"0.852588","0.0701369","tr|C9J236|C9J236_HUMAN;tr|C9JS27|C9JS27_HUMAN;sp|Q7L592|NDUF7_HUMAN;tr|C9JP36|C9JP36_HUMAN;tr|C9JEL7|C9JEL7_HUMAN","tr|C9J236|C9J236_HUMAN;tr|C9JS27|C9JS27_HUMAN;sp|Q7L592|NDUF7_HUMAN;tr|C9JP36|C9JP36_HUMAN",2969,"C9J236","C9J236_HUMAN","Protein arginine methyltransferase NDUFAF7 {ECO:0000256|RuleBase:RU364114}",null,"NDUFAF7"]
["19.978","19.1243","19.7358","17.6618",{"$nulls":3},"actin cytoskeleton organization;cell communication;endocytosis;membrane organization;regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity;identical protein binding;lipid binding","cell cortex;cell projection;cytoplasm;cytoskeleton;cytosol;extracellular exosome;Golgi apparatus;intracellular membrane-bounded organelle;lysosome;nucleoplasm;perinuclear region of cytoplasm;phagocytic cup","Insulin signaling pathway",null,null,10,10,10,"25.6","25.6","25.6","68.351",0,"36.257",226210000,13,"0.278518",1,"0.852311","0.760049","sp|Q15642|CIP4_HUMAN;tr|W4VSQ9|W4VSQ9_HUMAN;tr|M0R0F9|M0R0F9_HUMAN;tr|M0R2H7|M0R2H7_HUMAN;tr|M0R070|M0R070_HUMAN","sp|Q15642|CIP4_HUMAN;tr|W4VSQ9|W4VSQ9_HUMAN;tr|M0R0F9|M0R0F9_HUMAN;tr|M0R2H7|M0R2H7_HUMAN",2506,"Q15642","CIP4_HUMAN","Cdc42-interacting protein 4",null,"TRIP10"]
[1,"18.8865",1,"17.1958",{"$nulls":3},"metal ion transport;vacuolar transport",null,"intracellular",{"$nulls":3},1,1,1,"9.6","9.6","9.6","15.727","0.0052356","2.7404",3173600,1,"0.0220411",1,"0.845354","0.0700684","tr|H7C5F7|H7C5F7_HUMAN;tr|B4DGY6|B4DGY6_HUMAN;tr|A0A0C4DGW0|A0A0C4DGW0_HUMAN;sp|Q9NV92|NFIP2_HUMAN","tr|H7C5F7|H7C5F7_HUMAN;tr|B4DGY6|B4DGY6_HUMAN;tr|A0A0C4DGW0|A0A0C4DGW0_HUMAN;sp|Q9NV92|NFIP2_HUMAN",4481,"H7C5F7","H7C5F7_HUMAN",null,null,"NDFIP2"]
[1,"19.5154",1,"17.8321",{"$nulls":3},"cadmium ion transmembrane transport;calcium ion import;cellular calcium ion homeostasis;cellular zinc ion homeostasis;detoxification of cadmium ion;in utero embryonic development;negative regulation of calcium ion import;negative regulation of neurotransmitter secretion;negative regulation of zinc ion transmembrane import;regulation of sequestering of zinc ion;response to zinc ion;zinc II ion transport","calcium channel inhibitor activity;zinc ion transmembrane transporter activity","cytoplasm;endoplasmic reticulum;Golgi apparatus;integral component of membrane;nuclear membrane;plasma membrane;T-tubule","Mineral absorption",null,null,3,3,3,"6.7","6.7","6.7","55.299","0.006883","2.5019",27027000,1,"0.0211406",1,"0.84162","0.0672683","sp|Q9Y6M5|ZNT1_HUMAN","sp|Q9Y6M5|ZNT1_HUMAN",5106,"Q9Y6M5","ZNT1_HUMAN","Zinc transporter 1","nT-1","SLC30A1"]
["16.778","19.1891","17.6952","16.5985",{"$nulls":3},"cell proliferation;peptidyl-proline hydroxylation;protein hydroxylation;regulation of translational termination;stress granule assembly","iron ion binding;L-ascorbic acid binding;peptidyl-proline 3-dioxygenase activity;peptidyl-proline dioxygenase activity","cytoplasmic stress granule;cytosol;nucleus",{"$nulls":3},5,5,5,"14.6","14.6","14.6","63.245",0,"19.056",66451000,7,"0.227594",1,"0.83673","0.631781","sp|Q8N543|OGFD1_HUMAN;tr|A0A0A0MTR2|A0A0A0MTR2_HUMAN;tr|H3BR79|H3BR79_HUMAN;tr|H3BUA6|H3BUA6_HUMAN;tr|H3BR02|H3BR02_HUMAN","sp|Q8N543|OGFD1_HUMAN;tr|A0A0A0MTR2|A0A0A0MTR2_HUMAN",3232,"Q8N543","OGFD1_HUMAN","Prolyl 3-hydroxylase OGFOD1",null,"OGFOD1"]
["17.3551","17.3329","16.0807","16.9397",{"$nulls":3},"regulation of Rho protein signal transduction","Rho guanyl-nucleotide exchange factor activity","cytoplasm",{"$nulls":3},17,17,17,"16.4","16.4","16.4","164.66",0,"51.126",408880000,59,"0.717044",1,"0.833788","1.9405","sp|Q8TER5|ARH40_HUMAN;tr|G3V485|G3V485_HUMAN;tr|G3V3N2|G3V3N2_HUMAN;tr|G3V5C1|G3V5C1_HUMAN","sp|Q8TER5|ARH40_HUMAN",3399,"Q8TER5","ARH40_HUMAN","Rho guanine nucleotide exchange factor 40",null,"ARHGEF40"]
["19.0807","19.6224","18.8806","18.1554",{"$nulls":3},"DNA strand elongation involved in DNA replication;DNA strand elongation involved in mitotic DNA replication;inner cell mass cell proliferation","3'-5' DNA helicase activity","cytoplasm;GINS complex;nucleoplasm;nucleus",{"$nulls":3},3,3,3,23,23,23,"22.988",0,"9.0437",69120000,8,"0.684413",1,"0.833575","1.84197","sp|Q14691|PSF1_HUMAN","sp|Q14691|PSF1_HUMAN",2385,"Q14691","PSF1_HUMAN","DNA replication complex GINS protein PSF1",null,"GINS1"]
["17.3811","17.7496","17.0659","16.4009",{"$nulls":3},"cellular response to ionizing radiation;DNA repair;DNA synthesis involved in DNA repair;double-strand break repair via homologous recombination;interstrand cross-link repair;regulation of double-strand break repair via homologous recombination;strand displacement","double-stranded DNA binding;RNA binding;single-stranded DNA binding","nuclear chromatin;nucleoplasm;nucleus;protein complex",{"$nulls":3},5,5,5,"17.3","17.3","17.3","38.457",0,"13.622",133100000,25,"0.795601",1,"0.831951","2.18849","sp|Q96B01|R51A1_HUMAN;tr|F5H1Y0|F5H1Y0_HUMAN;tr|H0YGT5|H0YGT5_HUMAN;tr|H0YFK6|H0YFK6_HUMAN;tr|F5H4V6|F5H4V6_HUMAN;tr|F5H031|F5H031_HUMAN;tr|F5H710|F5H710_HUMAN","sp|Q96B01|R51A1_HUMAN;tr|F5H1Y0|F5H1Y0_HUMAN;tr|H0YGT5|H0YGT5_HUMAN",3606,"Q96B01","R51A1_HUMAN","RAD51-associated protein 1"]
["21.985","21.917","20.8942","21.344",{"$nulls":3},"attachment of spindle microtubules to kinetochore;cell division;microtubule bundle formation;microtubule polymerization;mitotic sister chromatid segregation;mitotic spindle assembly;mitotic spindle assembly checkpoint;protein stabilization;regulation of chromosome segregation;regulation of transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;heparin binding;microtubule binding;RNA binding;zinc ion binding","condensed chromosome kinetochore;cytoplasm;kinetochore;microtubule;nucleolus;nucleoplasm;nucleus;spindle;spindle matrix",{"$nulls":3},4,4,4,"11.3","11.3","11.3","50.75",0,"41.382",614190000,37,"1.17188",1,"0.831887","3.65686","sp|O43670|ZN207_HUMAN;tr|J3QRS9|J3QRS9_HUMAN;tr|X6R4W8|X6R4W8_HUMAN;tr|J3QS27|J3QS27_HUMAN;tr|J3KTL1|J3KTL1_HUMAN;tr|J3KRB6|J3KRB6_HUMAN;tr|J3KRW6|J3KRW6_HUMAN;tr|H0Y3M2|H0Y3M2_HUMAN;tr|J3KS31|J3KS31_HUMAN","sp|O43670|ZN207_HUMAN;tr|J3QRS9|J3QRS9_HUMAN;tr|X6R4W8|X6R4W8_HUMAN;tr|J3QS27|J3QS27_HUMAN;tr|J3KTL1|J3KTL1_HUMAN;tr|J3KRB6|J3KRB6_HUMAN;tr|J3KRW6|J3KRW6_HUMAN;tr|H0Y3M2|H0Y3M2_HUMAN;tr|J3KS31|J3KS31_HUMAN",418,"O43670","ZN207_HUMAN","BUB3-interacting and GLEBS motif-containing protein ZNF207 {ECO:0000303|PubMed:24462186, ECO:0000303|PubMed:24462187}","BuGZ {ECO:0000303|PubMed:26388440};uGZ {ECO:0000303|PubMed:24462186, ECO:0000303|PubMed:24462187}","ZNF207"]
["19.2753","18.9888","18.8553","17.7472",{"$nulls":3},"activation of innate immune response;aging;cellular protein localization;cellular response to dopamine;cellular response to glucose stimulus;DNA replication;hematopoietic progenitor cell differentiation;histone deacetylation;in utero embryonic development;negative regulation of apoptotic process;negative regulation of circadian rhythm;negative regulation of histone H3-K27 acetylation;negative regulation of protein localization to nucleus;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription regulatory region DNA binding;negative regulation of transcription, DNA-templated;positive regulation of chromatin silencing;positive regulation of defense response to virus by host;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of transcription from RNA polymerase II promoter;protein deacetylation;regulation of hormone levels;regulation of lipid metabolic process;regulation of megakaryocyte differentiation;regulation of transcription from RNA polymerase II promoter in response to oxidative stress;response to methylglyoxal;rhythmic process;transcription, DNA-templated","chromatin binding;DNA binding transcription factor activity;protein complex binding;protein deacetylase activity;RNA binding;RNA polymerase II activating transcription factor binding;RNA polymerase II repressing transcription factor binding;RNA polymerase II transcription corepressor activity;transcription regulatory region sequence-specific DNA binding","kinetochore;nucleolus;nucleoplasm;nucleus;Sin3 complex;transcription factor complex;transcriptional repressor complex","Epstein-Barr virus infection;Huntington disease;Thyroid hormone signaling pathway;Transcriptional misregulation in cancer",null,null,17,17,17,"17.5","17.5","17.5","145.17",0,"58.341",913430000,59,"0.547193",1,"0.830839","1.45187","sp|Q96ST3|SIN3A_HUMAN;tr|H3BP90|H3BP90_HUMAN;tr|H3BNZ3|H3BNZ3_HUMAN;tr|H3BMA2|H3BMA2_HUMAN;tr|H3BT34|H3BT34_HUMAN;tr|H3BQ76|H3BQ76_HUMAN;tr|H3BQ88|H3BQ88_HUMAN;tr|H3BNA0|H3BNA0_HUMAN;tr|H3BQL7|H3BQL7_HUMAN","sp|Q96ST3|SIN3A_HUMAN",3824,"Q96ST3","SIN3A_HUMAN","Paired amphipathic helix protein Sin3a",null,"SIN3A"]
["19.7134","19.9382","19.836","18.1551",{"$nulls":3},"cytoplasmic sequestering of protein;maintenance of unfolded protein involved in ERAD pathway;tail-anchored membrane protein insertion into ER membrane","chaperone binding","BAT3 complex;cytoplasm;cytosol;nucleolus;nucleoplasm",{"$nulls":3},4,4,4,"22.6","22.6","22.6","36.504",0,"15.151",108160000,8,"0.365755",1,"0.830253","0.979124","sp|Q7L5D6|GET4_HUMAN;tr|C9JPA8|C9JPA8_HUMAN;tr|C9JY46|C9JY46_HUMAN;tr|C9JHN8|C9JHN8_HUMAN","sp|Q7L5D6|GET4_HUMAN",2970,"Q7L5D6","GET4_HUMAN","Golgi to ER traffic protein 4 homolog",null,"GET4"]
["17.8394","19.0463","18.314","16.9211",{"$nulls":3},"B cell activation;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of stress-activated MAPK cascade;negative regulation of transcription from RNA polymerase II promoter;regulation of dephosphorylation;regulation of microtubule-based movement;response to interleukin-1;response to tumor necrosis factor;signal transduction","protein phosphatase 2A binding;protein phosphatase regulator activity","cytoplasm;cytosol","Autophagy - animal;Autophagy - other",null,null,4,4,4,"18.9","18.9","18.9","39.221",0,"10.277",53621000,9,"0.332574",1,"0.825311","0.895615","sp|P78318|IGBP1_HUMAN","sp|P78318|IGBP1_HUMAN",1969,"P78318","IGBP1_HUMAN","Immunoglobulin-binding protein 1",null,"IGBP1"]
["16.7328","16.1522","16.8739","14.3633",{"$nulls":3},"chromatin organization;covalent chromatin modification;DNA replication initiation;establishment of protein localization to chromatin","chromatin binding;methylated histone binding;methyl-CpG binding","condensed chromosome kinetochore;cytosol;kinetochore;microtubule organizing center;nuclear origin of replication recognition complex;nucleolus;nucleoplasm;nucleus;pericentric heterochromatin;telomeric heterochromatin",{"$nulls":3},8,8,8,19,19,19,"70.86",0,"60.686",344260000,36,"0.23063",1,"0.823896","0.639468","sp|Q9UFC0|LRWD1_HUMAN;tr|H7C5S6|H7C5S6_HUMAN;tr|F8WDB4|F8WDB4_HUMAN","sp|Q9UFC0|LRWD1_HUMAN;tr|H7C5S6|H7C5S6_HUMAN",4697,"Q9UFC0","LRWD1_HUMAN","Leucine-rich repeat and WD repeat-containing protein 1",null,"LRWD1"]
["19.8609","18.9492","19.1477","18.0156",{"$nulls":4},"ATP binding;protein kinase activity",{"$nulls":4},7,7,7,"13.5","13.5","13.5","77.053",0,"26.499",813980000,17,"0.426237",1,"0.823392","1.13297","tr|F8VSC5|F8VSC5_HUMAN;sp|Q6P3W7|SCYL2_HUMAN","tr|F8VSC5|F8VSC5_HUMAN;sp|Q6P3W7|SCYL2_HUMAN",2865,"F8VSC5","F8VSC5_HUMAN",null,null,"SCYL2"]
["20.9521","19.9679","20.1468","19.1268",{"$nulls":3},"long-chain fatty acid metabolic process;medium-chain fatty acid metabolic process;mitochondrial respiratory chain complex I assembly","flavin adenine dinucleotide binding;long-chain-acyl-CoA dehydrogenase activity;medium-chain-acyl-CoA dehydrogenase activity","dendrite;mitochondrial inner membrane;mitochondrial membrane;mitochondrion;nucleus",{"$nulls":3},13,13,13,"26.2","26.2","26.2","68.76",0,"50.741",431710000,26,"0.437345",1,"0.823221","1.16154","sp|Q9H845|ACAD9_HUMAN;tr|H0Y8Z9|H0Y8Z9_HUMAN;tr|D6RCD8|D6RCD8_HUMAN","sp|Q9H845|ACAD9_HUMAN;tr|H0Y8Z9|H0Y8Z9_HUMAN",4252,"Q9H845","ACAD9_HUMAN","Acyl-CoA dehydrogenase family member 9, mitochondrial","CAD-9","ACAD9"]
["23.7497","23.8417","23.4193","22.5332",{"$nulls":3},"adenine transport;behavioral fear response;learning;neuron-neuron synaptic transmission;regulation of cilium assembly","nucleotide binding;porin activity;voltage-gated anion channel activity","extracellular exosome;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion;nucleus;pore complex","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholesterol metabolism;Ferroptosis;Hepatitis B;Human T-cell leukemia virus 1 infection;Huntington disease;Necroptosis;NOD-like receptor signaling pathway;Parkinson disease;Viral carcinogenesis",null,null,12,12,12,"49.5","49.5","49.5","30.658",0,"113.46",1541300000,101,"0.683639",1,"0.819462","1.83966","sp|Q9Y277|VDAC3_HUMAN;tr|E5RFP6|E5RFP6_HUMAN;tr|E5RJN6|E5RJN6_HUMAN;tr|E5RHZ6|E5RHZ6_HUMAN;tr|E5RHE1|E5RHE1_HUMAN;tr|E5RK27|E5RK27_HUMAN;tr|E5RFL1|E5RFL1_HUMAN","sp|Q9Y277|VDAC3_HUMAN;tr|E5RFP6|E5RFP6_HUMAN;tr|E5RJN6|E5RJN6_HUMAN;tr|E5RHZ6|E5RHZ6_HUMAN",4900,"Q9Y277","VDAC3_HUMAN","Voltage-dependent anion-selective channel protein 3","DAC-3;VDAC3","VDAC3"]
["15.5359","16.482","14.9092","15.4765",{"$nulls":3},"cell differentiation","RNA binding",{"$nulls":4},4,3,2,"2.4",2,"1.3","242.96",0,"11.054",54552000,17,"0.557393",1,"0.816118","1.47968","sp|Q5JSZ5|PRC2B_HUMAN;tr|Q5JT00|Q5JT00_HUMAN","sp|Q5JSZ5|PRC2B_HUMAN",2698,"Q5JSZ5","PRC2B_HUMAN","Protein PRRC2B",null,"PRRC2B"]
["18.0893","17.6487","18.2267","15.8802",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;RNA export from nucleus;termination of RNA polymerase II transcription","ATP binding;ATP-dependent RNA helicase activity;RNA binding","catalytic step 2 spliceosome;cytoplasm;membrane;nucleoplasm;nucleus","Spliceosome",null,null,10,10,10,"9.5","9.5","9.5","140.5",0,"33.216",139810000,29,"0.247947",1,"0.81558","0.683198","sp|Q92620|PRP16_HUMAN;tr|H3BQT9|H3BQT9_HUMAN;tr|H3BV01|H3BV01_HUMAN;tr|J3KRT1|J3KRT1_HUMAN;tr|J3KSA8|J3KSA8_HUMAN;tr|H3BMS7|H3BMS7_HUMAN","sp|Q92620|PRP16_HUMAN",3510,"Q92620","PRP16_HUMAN","Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16",null,"DHX38"]
["15.9823","17.3154","16.0018","15.6722",{"$nulls":3},"activated T cell proliferation;CD4-positive, alpha-beta T cell differentiation;CD8-positive, alpha-beta T cell differentiation;chromatin organization;chromatin remodeling;epidermis development;execution phase of apoptosis;histone methylation;negative regulation of transcription from RNA polymerase II promoter;reflex;transcription, DNA-templated;viral process","chromatin binding;double-stranded DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","nuclear body;nuclear heterochromatin;nuclear matrix;nucleoplasm;nucleus;PML body",{"$nulls":3},4,2,2,"9.2","6.7","6.7","85.956","0.00068634","4.5024",25930000,8,"0.445375",1,"0.811801","1.18227","sp|Q01826|SATB1_HUMAN;tr|A0A087WW22|A0A087WW22_HUMAN;tr|A0A087WW75|A0A087WW75_HUMAN;tr|C9IZC5|C9IZC5_HUMAN;tr|C9JP21|C9JP21_HUMAN","sp|Q01826|SATB1_HUMAN",2056,"Q01826","SATB1_HUMAN","DNA-binding protein SATB1",null,"SATB1"]
["19.0191",1,"17.3972",1,{"$nulls":9},3,3,3,"11.9","11.9","11.9","30.48",0,"8.0187",51754000,5,"0.0209162",1,"0.810923","0.06657","sp|A6NCS6|CB072_HUMAN","sp|A6NCS6|CB072_HUMAN",166,"A6NCS6","CB072_HUMAN","Uncharacterized protein C2orf72",null,"C2orf72"]
["18.389","17.2642","17.1504","16.8815",{"$nulls":3},"endosome localization;protein transport;renal water homeostasis;vesicle-mediated transport","actin binding;ATP binding;calmodulin binding;microfilament motor activity;Rab GTPase binding","apical cortex;cytoplasmic vesicle membrane;extracellular exosome;myosin complex;protein complex",{"$nulls":3},55,55,21,"36.6","36.6","14.4","213.67",0,"289.45",2358400000,244,"0.528707",1,"0.810623","1.40186","sp|Q9ULV0|MYO5B_HUMAN;tr|Q7Z7A5|Q7Z7A5_HUMAN;tr|K7EPI3|K7EPI3_HUMAN;tr|Q9UES5|Q9UES5_HUMAN;tr|O95317|O95317_HUMAN;tr|E7ERV5|E7ERV5_HUMAN","sp|Q9ULV0|MYO5B_HUMAN",4825,"Q9ULV0","MYO5B_HUMAN","Unconventional myosin-Vb",null,"MYO5B"]
["19.6985","18.2371","17.8419","18.4743",{"$nulls":3},"isoprenoid biosynthetic process;protein heterotetramerization;regulation of body fluid levels;ubiquinone biosynthetic process","protein heterodimerization activity;trans-hexaprenyltranstransferase activity;trans-octaprenyltranstransferase activity","cytosol;mitochondrial matrix;transferase complex","Terpenoid backbone biosynthesis",null,null,4,4,4,"16.5","16.5","16.5","44.128",0,"27.219",106090000,8,"0.380717",1,"0.809695","1.01695","sp|Q86YH6|DLP1_HUMAN;tr|Q5JRD6|Q5JRD6_HUMAN","sp|Q86YH6|DLP1_HUMAN",3093,"Q86YH6","DLP1_HUMAN","Decaprenyl-diphosphate synthase subunit 2",null,"PDSS2"]
["22.254","23.4456","22.4367","21.6439",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;retrograde vesicle-mediated transport, Golgi to ER;toxin transport",null,"COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi membrane;transport vesicle",{"$nulls":3},4,4,4,35,35,35,"20.198",0,"27.833",191620000,11,"0.42557",1,"0.809526","1.13125","sp|P61923|COPZ1_HUMAN;tr|F8VVA7|F8VVA7_HUMAN;tr|F8VXB1|F8VXB1_HUMAN;tr|F8VUC5|F8VUC5_HUMAN;tr|F8W156|F8W156_HUMAN;tr|F8W651|F8W651_HUMAN;tr|F8VYZ4|F8VYZ4_HUMAN;tr|F8VXR1|F8VXR1_HUMAN;tr|F8VYK5|F8VYK5_HUMAN","sp|P61923|COPZ1_HUMAN;tr|F8VVA7|F8VVA7_HUMAN;tr|F8VXB1|F8VXB1_HUMAN;tr|F8VUC5|F8VUC5_HUMAN;tr|F8W156|F8W156_HUMAN;tr|F8W651|F8W651_HUMAN;tr|F8VYZ4|F8VYZ4_HUMAN;tr|F8VXR1|F8VXR1_HUMAN",1858,"P61923","COPZ1_HUMAN","Coatomer subunit zeta-1",null,"COPZ1"]
["16.8011","20.2061","17.533","17.8603",{"$nulls":3},"dTMP biosynthetic process;dUMP biosynthetic process;nucleobase-containing small molecule interconversion;pyrimidine nucleotide metabolic process","dCMP deaminase activity;identical protein binding;zinc ion binding","cytoplasm;cytosol;extracellular exosome","Metabolic pathways;Pyrimidine metabolism",null,null,2,2,2,"17.4","17.4","17.4","20.016",0,"8.611",46772000,9,"0.16524",1,"0.806949","0.471801","sp|P32321|DCTD_HUMAN;tr|D6RAD7|D6RAD7_HUMAN;tr|D6RAR9|D6RAR9_HUMAN;tr|D6RC36|D6RC36_HUMAN;tr|D6R9S0|D6R9S0_HUMAN;tr|D6RBN2|D6RBN2_HUMAN;tr|D6RBJ9|D6RBJ9_HUMAN","sp|P32321|DCTD_HUMAN;tr|D6RAD7|D6RAD7_HUMAN;tr|D6RAR9|D6RAR9_HUMAN;tr|D6RC36|D6RC36_HUMAN;tr|D6R9S0|D6R9S0_HUMAN;tr|D6RBN2|D6RBN2_HUMAN;tr|D6RBJ9|D6RBJ9_HUMAN",1348,"P32321","DCTD_HUMAN","Deoxycytidylate deaminase",null,"DCTD"]
[1,"15.3901","13.7798",1,{"$nulls":3},"cell proliferation;DNA dealkylation involved in DNA repair;DNA duplex unwinding;regulation of transcription, DNA-templated;transcription, DNA-templated","ATP binding;ATP-dependent 3'-5' DNA helicase activity;RNA binding","activating signal cointegrator 1 complex;cytosol;intracellular;membrane;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"1.7","1.7","1.7","251.46","0.00026399","7.5092",25841000,11,"0.0264375",1,"0.805123","0.0836677","sp|Q8N3C0|ASCC3_HUMAN;tr|J3KNJ4|J3KNJ4_HUMAN;tr|E5RFZ0|E5RFZ0_HUMAN","sp|Q8N3C0|ASCC3_HUMAN",3213,"Q8N3C0","ASCC3_HUMAN","Activating signal cointegrator 1 complex subunit 3",null,"ASCC3"]
[1,"15.2219",1,"13.6238",{"$nulls":3},"liver regeneration;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of membrane protein ectodomain proteolysis;negative regulation of mitotic cell cycle;protein dephosphorylation;regulation of membrane depolarization during action potential;regulation of sodium ion transmembrane transporter activity","ATPase binding;cytoskeletal protein binding;phosphotyrosine residue binding;protein tyrosine phosphatase activity;sodium channel regulator activity","cytoplasm;cytoplasmic side of plasma membrane;cytoskeleton;plasma membrane",{"$nulls":3},10,10,10,"16.5","16.5","16.5","103.99",0,"25.818",230260000,30,"0.0265576",1,"0.799042","0.0840375","sp|P26045|PTN3_HUMAN;tr|J3KN34|J3KN34_HUMAN","sp|P26045|PTN3_HUMAN;tr|J3KN34|J3KN34_HUMAN",1234,"P26045","PTN3_HUMAN","Tyrosine-protein phosphatase non-receptor type 3",null,"PTPN3"]
["18.9441","15.7507","18.1902","14.9132",{"$nulls":3},"beta-catenin-TCF complex assembly;cellular response to DNA damage stimulus;histone H3-K4 methylation;post-translational protein modification;regulation of megakaryocyte differentiation;regulation of transcription, DNA-templated;response to estrogen;transcription, DNA-templated","histone-lysine N-methyltransferase activity;methylated histone binding;transcription regulatory region DNA binding","histone methyltransferase complex;MLL1 complex;MLL3/4 complex;nucleolus;nucleoplasm;nucleus;Set1C/COMPASS complex","Cushing syndrome",null,null,4,4,4,"15.4","15.4","15.4","59.152",0,"8.778",105630000,28,"0.118509",1,"0.795695","0.347798","sp|Q15291|RBBP5_HUMAN","sp|Q15291|RBBP5_HUMAN",2469,"Q15291","RBBP5_HUMAN","Retinoblastoma-binding protein 5","BBP-5","RBBP5"]
["17.4214","16.3341","17.5917","14.5774",{"$nulls":3},"circadian regulation of gene expression;negative regulation of epithelial cell proliferation;negative regulation of transcription, DNA-templated;positive regulation of apoptotic signaling pathway;positive regulation of branching involved in ureteric bud morphogenesis;positive regulation of MAP kinase activity;positive regulation of transcription, DNA-templated;regulation of apoptotic process;regulation of circadian rhythm;regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated","identical protein binding;transcription coactivator activity","chromatin;cytoplasm;nucleus;plasma membrane;protein complex","Neurotrophin signaling pathway",null,null,3,3,3,"4.9","4.9","4.9","86.16",0,"131.33",108760000,23,"0.17419",1,"0.79322","0.495071","sp|Q9Y5V3|MAGD1_HUMAN","sp|Q9Y5V3|MAGD1_HUMAN",5059,"Q9Y5V3","MAGD1_HUMAN","Melanoma-associated antigen D1",null,"MAGED1"]
["16.5185","18.1992","17.471","15.6656",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;transcription from RNA polymerase III promoter;transcription, DNA-templated;tRNA transcription from RNA polymerase III promoter",null,"nucleoplasm;transcription factor TFIIIC complex",{"$nulls":3},9,9,9,"16.6","16.6","16.6","100.68",0,"22.656",228760000,28,"0.23121",1,"0.790482","0.640936","sp|Q8WUA4|TF3C2_HUMAN;tr|A0A087WZD8|A0A087WZD8_HUMAN;tr|H0Y4Q6|H0Y4Q6_HUMAN;tr|C9JNH7|C9JNH7_HUMAN;tr|H7C318|H7C318_HUMAN;tr|H7C3X9|H7C3X9_HUMAN","sp|Q8WUA4|TF3C2_HUMAN;tr|A0A087WZD8|A0A087WZD8_HUMAN",3416,"Q8WUA4","TF3C2_HUMAN","General transcription factor 3C polypeptide 2",null,"GTF3C2"]
["18.8746","18.449","18.6309","17.1132",{"$nulls":3},"blastocyst growth;cellular response to lipopolysaccharide;endodermal cell fate commitment;histone H2B ubiquitination;histone H3-K4 trimethylation;histone monoubiquitination;inner cell mass cell differentiation;interleukin-6-mediated signaling pathway;JAK-STAT cascade;negative regulation of mRNA polyadenylation;negative regulation of myeloid cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of histone H2B ubiquitination;positive regulation of histone H3-K4 methylation;positive regulation of histone H3-K79 methylation;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein ubiquitination;regulation of genetic imprinting;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;trophectodermal cell differentiation;Wnt signaling pathway","RNA polymerase II core binding;SH2 domain binding","Cdc73/Paf1 complex;nuclear speck;nucleoplasm;transcriptionally active chromatin",{"$nulls":3},14,14,14,"15.9","15.9","15.9","133.5",0,"54.215",427370000,52,"0.374818",1,"0.789726","1.00202","sp|Q6PD62|CTR9_HUMAN;tr|H0YCE8|H0YCE8_HUMAN","sp|Q6PD62|CTR9_HUMAN",2876,"Q6PD62","CTR9_HUMAN","RNA polymerase-associated protein CTR9 homolog",null,"CTR9"]
["18.0879","18.7828","18.0055","17.2874",{"$nulls":9},3,3,3,"12.1","12.1","12.1","53.458",0,"10.979",53845000,14,"0.59329",1,"0.788932","1.57897","tr|J3KND1|J3KND1_HUMAN;sp|Q96ER3|SAAL1_HUMAN;tr|E9PRZ1|E9PRZ1_HUMAN;tr|H0YEK5|H0YEK5_HUMAN;tr|E9PMD2|E9PMD2_HUMAN;tr|H0YCN7|H0YCN7_HUMAN","tr|J3KND1|J3KND1_HUMAN;sp|Q96ER3|SAAL1_HUMAN;tr|E9PRZ1|E9PRZ1_HUMAN;tr|H0YEK5|H0YEK5_HUMAN;tr|E9PMD2|E9PMD2_HUMAN",3670,"J3KND1","J3KND1_HUMAN"]
["18.7021","19.3589","19.0635","17.4197",{"$nulls":3},"DNA replication;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity","nucleus",{"$nulls":3},7,6,6,"30.8","28.4","28.4","49.193",0,"66.276",349450000,31,"0.330845",1,"0.788864","0.891274","tr|K7EN08|K7EN08_HUMAN;sp|Q14938|NFIX_HUMAN;tr|C9JWJ8|C9JWJ8_HUMAN;tr|K7ESG9|K7ESG9_HUMAN;tr|K7EKH0|K7EKH0_HUMAN;tr|K7EJB0|K7EJB0_HUMAN;tr|K7EMQ5|K7EMQ5_HUMAN","tr|K7EN08|K7EN08_HUMAN;sp|Q14938|NFIX_HUMAN;tr|C9JWJ8|C9JWJ8_HUMAN",2404,"K7EN08","K7EN08_HUMAN","Nuclear factor 1 {ECO:0000256|RuleBase:RU000690}",null,"NFIX"]
["19.7371","19.9015","19.842","18.2199",{"$nulls":3},"cell differentiation;negative regulation of T cell receptor signaling pathway;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of B cell receptor signaling pathway;regulation of cytokine production;regulation of cytokine-mediated signaling pathway","DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nucleoplasm;nucleus",{"$nulls":3},9,9,9,"27.1","27.1","27.1","67.497",0,"30.673",259730000,42,"0.360982",1,"0.788372","0.967082","sp|P32519|ELF1_HUMAN;tr|Q6MZZ4|Q6MZZ4_HUMAN","sp|P32519|ELF1_HUMAN;tr|Q6MZZ4|Q6MZZ4_HUMAN",1350,"P32519","ELF1_HUMAN","ETS-related transcription factor Elf-1",null,"ELF1"]
["14.3096","15.9206","15.2159","13.4389",{"$nulls":3},"cation transport;cellular response to mechanical stimulus;detection of mechanical stimulus;positive regulation of cell-cell adhesion mediated by integrin;positive regulation of integrin activation;regulation of membrane potential","cation channel activity;mechanosensitive ion channel activity","endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;integral component of membrane;lamellipodium membrane;plasma membrane",{"$nulls":3},3,3,3,"2.5","2.5","2.5","286.79","0.00025138","6.4667",40340000,9,"0.237499",1,"0.787715","0.656837","sp|Q92508|PIEZ1_HUMAN;tr|H0YB49|H0YB49_HUMAN","sp|Q92508|PIEZ1_HUMAN",3483,"Q92508","PIEZ1_HUMAN","Piezo-type mechanosensitive ion channel component 1",null,"PIEZO1"]
["16.7272",1,"15.1558",1,{"$nulls":3},"cobalamin biosynthetic process;cobalamin metabolic process;short-chain fatty acid catabolic process","GTP binding;GTPase activity;identical protein binding;protein homodimerization activity","mitochondrial matrix",{"$nulls":3},5,5,5,"14.4","14.4","14.4","46.538",0,"9.5601",49202000,8,"0.0233927",1,"0.785679","0.0742618","sp|Q8IVH4|MMAA_HUMAN;tr|Q495G5|Q495G5_HUMAN;tr|D6RIS5|D6RIS5_HUMAN","sp|Q8IVH4|MMAA_HUMAN;tr|Q495G5|Q495G5_HUMAN;tr|D6RIS5|D6RIS5_HUMAN",3114,"Q8IVH4","MMAA_HUMAN","Methylmalonic aciduria type A protein, mitochondrial {ECO:0000305}",null,"MMAA"]
["19.4903","20.3958","19.8407","18.4748",{"$nulls":3},"cellular response to interferon-gamma;positive regulation of actin filament polymerization;positive regulation of pseudopodium assembly;regulation of cell shape;Rho protein signal transduction","GTPase activator activity;GTP-Rho binding;RNA binding","actin cytoskeleton;cell-cell adherens junction;cytoplasm;endomembrane system;microtubule cytoskeleton;phagocytic vesicle;plasma membrane",{"$nulls":3},5,5,5,"27.8","27.8","27.8","37.979",0,"14.332",116040000,23,"0.357536",1,"0.785302","0.958396","sp|Q9H3Q1|BORG4_HUMAN;tr|J3KRZ9|J3KRZ9_HUMAN;tr|J3QQS6|J3QQS6_HUMAN;tr|J3QR93|J3QR93_HUMAN","sp|Q9H3Q1|BORG4_HUMAN;tr|J3KRZ9|J3KRZ9_HUMAN",4193,"Q9H3Q1","BORG4_HUMAN","Cdc42 effector protein 4",null,"CDC42EP4"]
["17.6776","18.6535","17.6348","17.139",{"$nulls":4},"electron transfer activity;iron ion binding;L-ascorbic acid binding;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;procollagen-proline 4-dioxygenase activity","cytosol;endoplasmic reticulum;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;nucleoplasm","Arginine and proline metabolism;Metabolic pathways",null,null,3,3,3,8,8,8,"60.901","0.00026575","7.6355",52474000,8,"0.536381",1,"0.778639","1.42256","sp|O15460|P4HA2_HUMAN;tr|C9JN43|C9JN43_HUMAN;tr|C9JIG4|C9JIG4_HUMAN;tr|C9JCP0|C9JCP0_HUMAN;tr|C9JX45|C9JX45_HUMAN;tr|A8MXE0|A8MXE0_HUMAN;tr|E7ERI1|E7ERI1_HUMAN;tr|E7ENX0|E7ENX0_HUMAN;tr|E7EPI9|E7EPI9_HUMAN","sp|O15460|P4HA2_HUMAN",366,"O15460","P4HA2_HUMAN","Prolyl 4-hydroxylase subunit alpha-2",{"$f":"-PH alpha-2","v":{"$error":"#NAME?"}},"P4HA2"]
["18.5056","19.8296","17.7774","19.0028",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;cargo loading into COPII-coated vesicle;COPII vesicle coating;ER to Golgi vesicle-mediated transport;in utero embryonic development;intracellular protein transport","SNARE binding;zinc ion binding","COPII vesicle coat;cytosol;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane","Protein processing in endoplasmic reticulum",null,null,6,6,6,"8.5","8.5","8.5","113.01",0,"27.521",137700000,13,"0.319164",1,"0.7775","0.861963","sp|O94855|SC24D_HUMAN;tr|E9PDM8|E9PDM8_HUMAN;tr|E9PC44|E9PC44_HUMAN","sp|O94855|SC24D_HUMAN;tr|E9PDM8|E9PDM8_HUMAN",659,"O94855","SC24D_HUMAN","Protein transport protein Sec24D {ECO:0000305}",null,"SEC24D"]
["19.0487","19.7774","18.9643","18.3074",{"$nulls":3},"N-acetylneuraminate metabolic process","N-acylneuraminate cytidylyltransferase activity","membrane;nucleoplasm;nucleus","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,5,5,5,"18.7","18.7","18.7","48.379",0,"12.82",142670000,14,"0.595216",1,"0.777163","1.58436","sp|Q8NFW8|NEUA_HUMAN;tr|F5H296|F5H296_HUMAN;tr|F5GYM0|F5GYM0_HUMAN","sp|Q8NFW8|NEUA_HUMAN",3343,"Q8NFW8","NEUA_HUMAN","N-acylneuraminate cytidylyltransferase",null,"CMAS"]
["17.1731","19.6756","17.5615","17.7328",{"$nulls":3},"osteoblast differentiation","NADP-retinol dehydrogenase activity;oxidoreductase activity","endoplasmic reticulum;endoplasmic reticulum membrane;lysosomal membrane;membrane;mitochondrion;nucleus",{"$nulls":3},4,4,4,"18.5","18.5","18.5","36.864",0,"9.6814",46323000,13,"0.222811",1,"0.777157","0.619654","sp|Q9HBH5|RDH14_HUMAN;tr|C9J2C7|C9J2C7_HUMAN","sp|Q9HBH5|RDH14_HUMAN",4309,"Q9HBH5","RDH14_HUMAN","Retinol dehydrogenase 14",null,"RDH14"]
["21.3654","22.479","21.3582","20.933",{"$nulls":9},2,2,2,"21.2","21.2","21.2","5.7856","0.0037136","3.0561",68407000,2,"0.491613",1,"0.776593","1.30303","tr|J3KSI4|J3KSI4_HUMAN;tr|I3L405|I3L405_HUMAN;tr|I3L261|I3L261_HUMAN;tr|I3L1D2|I3L1D2_HUMAN;tr|I3L4E0|I3L4E0_HUMAN;tr|J3QS48|J3QS48_HUMAN;tr|I3L295|I3L295_HUMAN;tr|J3KTK8|J3KTK8_HUMAN;tr|J3QQZ4|J3QQZ4_HUMAN;tr|J3KT75|J3KT75_HUMAN;tr|J3QW43|J3QW43_HUMAN;tr|J3QRD5|J3QRD5_HUMAN;tr|Q9H3L2|Q9H3L2_HUMAN;sp|O75352|MPU1_HUMAN;tr|Q1HDL3|Q1HDL3_HUMAN;tr|A0A087WV81|A0A087WV81_HUMAN","tr|J3KSI4|J3KSI4_HUMAN;tr|I3L405|I3L405_HUMAN;tr|I3L261|I3L261_HUMAN;tr|I3L1D2|I3L1D2_HUMAN;tr|I3L4E0|I3L4E0_HUMAN;tr|J3QS48|J3QS48_HUMAN;tr|I3L295|I3L295_HUMAN;tr|J3KTK8|J3KTK8_HUMAN;tr|J3QQZ4|J3QQZ4_HUMAN;tr|J3KT75|J3KT75_HUMAN;tr|J3QW43|J3QW43_HUMAN;tr|J3QRD5|J3QRD5_HUMAN;tr|Q9H3L2|Q9H3L2_HUMAN;sp|O75352|MPU1_HUMAN;tr|Q1HDL3|Q1HDL3_HUMAN;tr|A0A087WV81|A0A087WV81_HUMAN",550,"J3KSI4","J3KSI4_HUMAN",null,null,"MPDU1"]
["16.755","17.597","15.7324","17.0667",{"$nulls":5},"cytoskeleton;cytosol;filopodium;membrane;nucleoplasm;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},5,5,5,"8.2","8.2","8.2","73.91",0,"15.905",62743000,10,"0.367797",1,"0.776459","0.984278","sp|Q9H4E7|DEFI6_HUMAN","sp|Q9H4E7|DEFI6_HUMAN",4209,"Q9H4E7","DEFI6_HUMAN","Differentially expressed in FDCP 6 homolog","EF-6","DEF6"]
["19.8935","19.48","19.8445","17.9767",{"$nulls":3},"actin cytoskeleton reorganization;AV node cell to bundle of His cell communication;AV node cell-bundle of His cell adhesion involved in cell communication;cardiac muscle fiber development;cell-cell junction organization;defense response to virus;epithelial structure maintenance;gamma-delta T cell activation;germ cell migration;heart development;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;homotypic cell-cell adhesion;leukocyte migration;mitochondrion organization;neutrophil chemotaxis;regulation of AV node cell action potential;regulation of immune response;transepithelial transport","beta-catenin binding;cell adhesion molecule binding;cell adhesive protein binding involved in AV node cell-bundle of His cell communication;connexin binding;identical protein binding;integrin binding;PDZ domain binding;receptor binding;virus receptor activity","acrosomal vesicle;adherens junction;apicolateral plasma membrane;basolateral plasma membrane;bicellular tight junction;cell body;cell junction;cell-cell adherens junction;cell-cell junction;cytoplasm;extracellular region;extracellular space;filopodium;growth cone;integral component of plasma membrane;intercalated disc;membrane raft;neuromuscular junction;neuron projection;nucleoplasm;plasma membrane;protein complex","Viral myocarditis",null,null,6,6,6,"19.2","19.2","19.2","40.029",0,"17.703",180660000,18,"0.299014",1,"0.776156","0.811444","sp|P78310|CXAR_HUMAN","sp|P78310|CXAR_HUMAN",1966,"P78310","CXAR_HUMAN","Coxsackievirus and adenovirus receptor","AR;CAR","CXADR"]
["18.5988","16.926","18.7013","15.2729",{"$nulls":3},"amygdala development;cellular response to DNA damage stimulus;dendritic spine development;hippocampus development;learning;locomotory behavior;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process","ATP binding;FAT10 activating enzyme activity;ubiquitin activating enzyme activity","cytoplasm;cytosol","Ubiquitin mediated proteolysis",null,null,8,8,8,9,9,9,"117.97",0,"15.222",107900000,12,"0.140407",1,"0.775301","0.406484","sp|A0AVT1|UBA6_HUMAN;tr|H0Y8S8|H0Y8S8_HUMAN","sp|A0AVT1|UBA6_HUMAN;tr|H0Y8S8|H0Y8S8_HUMAN",150,"A0AVT1","UBA6_HUMAN","Ubiquitin-like modifier-activating enzyme 6","biquitin-activating enzyme 6","UBA6"]
["16.6313","16.6737","16.6709","15.0886",{"$nulls":3},"endosome organization;Golgi organization;phosphatidylinositol phosphorylation","1-phosphatidylinositol 4-kinase activity","endosome;lysosomal membrane;plasma membrane;trans-Golgi network",{"$nulls":3},3,3,3,"7.1","7.1","7.1","51.218","0.00066711","4.0866",20641000,3,"0.364646",1,"0.772721","0.976324","tr|E9PAM4|E9PAM4_HUMAN;sp|Q9BTU6|P4K2A_HUMAN","tr|E9PAM4|E9PAM4_HUMAN;sp|Q9BTU6|P4K2A_HUMAN",3971,"E9PAM4","E9PAM4_HUMAN"]
["17.1947","16.877","16.5734","15.957",{"$nulls":5},"nuclear body;nucleolus;nucleus",{"$nulls":3},4,4,4,"7.3","7.3","7.3","80.321","0.00025927","7.1693",44289000,10,"0.806024",1,"0.770656","2.22263","tr|J3QQW9|J3QQW9_HUMAN;sp|Q15022|SUZ12_HUMAN","tr|J3QQW9|J3QQW9_HUMAN;sp|Q15022|SUZ12_HUMAN",2428,"J3QQW9","J3QQW9_HUMAN",null,null,"SUZ12"]
["21.1613","20.8331","19.8701","20.5886",{"$nulls":3},"cytoplasmic mRNA processing body assembly;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;mRNA processing;mRNA splicing, via spliceosome","RNA binding","catalytic step 2 spliceosome;cytosol;Lsm1-7-Pat1 complex;nucleoplasm;nucleus;P-body;precatalytic spliceosome;U4/U6 x U5 tri-snRNP complex;U6 snRNP","RNA degradation;Spliceosome",null,null,2,2,2,"32.4","32.4","32.4","11.845",0,"8.9506",54629000,8,"0.718236",1,"0.767851","1.94414","sp|P62310|LSM3_HUMAN","sp|P62310|LSM3_HUMAN",1889,"P62310","LSM3_HUMAN","U6 snRNA-associated Sm-like protein LSm3",null,"LSM3"]
["15.2477","18.5327","15.3712","16.8891",{"$nulls":4},"RNA binding","nuclear membrane;nucleus",{"$nulls":3},22,12,12,"12.1","7.4","7.4","263.25",0,"26.555",195270000,35,"0.145541",1,"0.760067","0.420084","tr|H0YM23|H0YM23_HUMAN;sp|O75179|ANR17_HUMAN;tr|H0YLQ3|H0YLQ3_HUMAN","tr|H0YM23|H0YM23_HUMAN;sp|O75179|ANR17_HUMAN",537,"H0YM23","H0YM23_HUMAN",null,null,"ANKRD17"]
["16.3944","16.5418","16.541","14.8803",{"$nulls":4},"nucleic acid binding;zinc ion binding","cytosol;nucleus",{"$nulls":3},1,1,1,"3.9","3.9","3.9","40.471","0.0050373","2.7497",9061200,3,"0.337745",1,"0.757417","0.908601","tr|A0A087WZG9|A0A087WZG9_HUMAN;tr|B4DSP0|B4DSP0_HUMAN;tr|A0A087WXK2|A0A087WXK2_HUMAN;sp|Q86TG7|PEG10_HUMAN;tr|A0A087WUL4|A0A087WUL4_HUMAN;tr|A0A087WX23|A0A087WX23_HUMAN","tr|A0A087WZG9|A0A087WZG9_HUMAN;tr|B4DSP0|B4DSP0_HUMAN;tr|A0A087WXK2|A0A087WXK2_HUMAN;sp|Q86TG7|PEG10_HUMAN;tr|A0A087WUL4|A0A087WUL4_HUMAN;tr|A0A087WX23|A0A087WX23_HUMAN",3033,"A0A087WZG9","A0A087WZG9_HUMAN",null,null,"PEG10"]
["20.1328","20.1631","20.2414","18.5443",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;ribosomal small subunit assembly","GTP binding;ribosomal small subunit binding;RNA binding;rRNA binding","cytosol;mitochondrial inner membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},9,9,9,27,27,27,"48.349",0,"48.451",680230000,90,"0.330221",1,"0.75508","0.889707","sp|O75616|ERAL1_HUMAN;tr|J3QSB2|J3QSB2_HUMAN;tr|J3QRV9|J3QRV9_HUMAN;tr|K7EQJ8|K7EQJ8_HUMAN;tr|J3QT61|J3QT61_HUMAN","sp|O75616|ERAL1_HUMAN;tr|J3QSB2|J3QSB2_HUMAN;tr|J3QRV9|J3QRV9_HUMAN",594,"O75616","ERAL1_HUMAN","GTPase Era, mitochondrial","ERA;-ERA","ERAL1"]
["22.2479","22.1163","22.1834","20.6791",{"$nulls":3},"cell division;G2/M transition of mitotic cell cycle;mitotic cell cycle;negative regulation of protein dephosphorylation;regulation of insulin secretion;response to glucose;response to nutrient;transport","ion channel inhibitor activity;phosphatase inhibitor activity;potassium channel inhibitor activity;protein phosphatase 2A binding;protein phosphatase inhibitor activity;protein phosphatase regulator activity;receptor binding","cytoplasm;nucleoplasm",{"$nulls":3},8,8,7,"66.1","66.1",57,"13.389",0,"30.72",343940000,35,"0.371806",1,"0.750827","0.994404","sp|O43768|ENSA_HUMAN;tr|A6NMQ3|A6NMQ3_HUMAN;tr|Q5T5H1|Q5T5H1_HUMAN","sp|O43768|ENSA_HUMAN;tr|A6NMQ3|A6NMQ3_HUMAN;tr|Q5T5H1|Q5T5H1_HUMAN",433,"O43768","ENSA_HUMAN","Alpha-endosulfine",null,"ENSA"]
[1,"19.2342",1,"17.7363",{"$nulls":3},"histone deubiquitination;negative regulation of insulin secretion involved in cellular response to glucose stimulus;poly(A)+ mRNA export from nucleus;positive regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","chromatin binding;ligand-dependent nuclear receptor transcription coactivator activity;transcription coactivator activity","DUBm complex;mitochondrion;nuclear pore;nucleoplasm;SAGA complex",{"$nulls":3},2,2,2,"24.8","24.8","24.8","11.528",0,"9.1434",93686000,8,"0.0189766",1,"0.748941","0.060519","sp|Q9NPA8|ENY2_HUMAN;tr|E5RHX8|E5RHX8_HUMAN","sp|Q9NPA8|ENY2_HUMAN;tr|E5RHX8|E5RHX8_HUMAN",4361,"Q9NPA8","ENY2_HUMAN","Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046}",null,"ENY2"]
["21.7172","21.1309","21.1439","20.2084",{"$nulls":4},"aldehyde dehydrogenase (NAD) activity","extracellular exosome;membrane",{"$nulls":3},13,13,13,"23.4","23.4","23.4","85.126",0,"66.284",457690000,51,"0.511139",1,"0.747895","1.35482","sp|Q8IZ83|A16A1_HUMAN;tr|F5H4B6|F5H4B6_HUMAN;tr|M0QY06|M0QY06_HUMAN","sp|Q8IZ83|A16A1_HUMAN;tr|F5H4B6|F5H4B6_HUMAN",3177,"Q8IZ83","A16A1_HUMAN","Aldehyde dehydrogenase family 16 member A1",null,"ALDH16A1"]
["22.3288","23.2661","22.5337","21.5709",{"$nulls":3},"mesoderm development;phagocytosis;positive regulation of skeletal muscle acetylcholine-gated channel clustering;protein folding;protein localization to cell surface;Wnt signaling pathway","identical protein binding;low-density lipoprotein particle receptor binding","endoplasmic reticulum;plasma membrane",{"$nulls":3},13,13,13,"54.7","54.7","54.7","26.076",0,"61.166",691200000,60,"0.41693",1,"0.74515","1.10911","sp|Q14696|MESD_HUMAN;tr|H0YLI4|H0YLI4_HUMAN","sp|Q14696|MESD_HUMAN",2388,"Q14696","MESD_HUMAN","LRP chaperone MESD {ECO:0000305}",null,"MESD"]
["17.5905","18.4805","15.6421","18.9391",{"$nulls":3},"acrosome assembly;adherens junction organization;adhesion of symbiont to host;cell part morphogenesis;cell recognition;cilium organization;coreceptor-mediated virion attachment to host cell;cytoskeleton organization;establishment of mitochondrion localization;fertilization;fusion of virus membrane with host plasma membrane;heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;homophilic cell adhesion via plasma membrane adhesion molecules;positive regulation of immunoglobulin mediated immune response;positive regulation of mast cell activation;positive regulation of natural killer cell mediated cytotoxicity;positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;positive regulation of T cell receptor signaling pathway;regulation of immune response;regulation of viral entry into host cell;sperm mitochondrion organization;spermatid development;spermatid nucleus differentiation;susceptibility to natural killer cell mediated cytotoxicity;susceptibility to T cell mediated cytotoxicity","cell adhesion molecule binding;coreceptor activity;identical protein binding;protein heterodimerization activity;protein homodimerization activity;receptor binding;virus receptor activity","cell surface;cell-cell adherens junction;cell-cell contact zone;cell-cell junction;extracellular exosome;focal adhesion;integral component of membrane;integral component of plasma membrane;plasma membrane;zonula adherens","Adherens junction;Cell adhesion molecules (CAMs)",null,null,6,6,6,"17.1","17.1","17.1","57.741",0,"10.146",89982000,8,"0.15167",1,"0.744891","0.436254","sp|Q92692|PVRL2_HUMAN;tr|K7EKE8|K7EKE8_HUMAN","sp|Q92692|PVRL2_HUMAN;tr|K7EKE8|K7EKE8_HUMAN",3519,"Q92692","NECT2_HUMAN","Nectin-2",null,"NECTIN2"]
["18.1974","19.6832","18.1423","18.2515",{"$nulls":3},"cellular homeostasis;mitochondrial outer membrane permeabilization;mitochondrion transport along microtubule;regulation of small GTPase mediated signal transduction","calcium ion binding;GTP binding;GTPase activity","cytosol;extracellular exosome;integral component of mitochondrial outer membrane;membrane;plasma membrane","Mitophagy - animal",null,null,5,5,4,"10.8","10.8","9.1","68.117",0,"13.589",95866000,9,"0.373236",1,"0.743428","0.99802","sp|Q8IXI1|MIRO2_HUMAN;tr|H3BST5|H3BST5_HUMAN;tr|I3L2C6|I3L2C6_HUMAN;tr|H3BMP9|H3BMP9_HUMAN;tr|H3BVI5|H3BVI5_HUMAN;tr|H3BUX4|H3BUX4_HUMAN","sp|Q8IXI1|MIRO2_HUMAN;tr|H3BST5|H3BST5_HUMAN;tr|I3L2C6|I3L2C6_HUMAN",3145,"Q8IXI1","MIRO2_HUMAN","Mitochondrial Rho GTPase 2","IRO-2;Miro-2","RHOT2"]
[1,"19.1026",1,"17.6185",{"$nulls":4},"metal ion binding","nucleus",{"$nulls":3},2,2,2,"11.2","11.2","11.2","20.769","0.00023759","5.2838",9991500,2,"0.0189365",1,"0.742055","0.0603937","tr|E5RJW4|E5RJW4_HUMAN;sp|Q9NW64|RBM22_HUMAN;tr|E5RHA8|E5RHA8_HUMAN","tr|E5RJW4|E5RJW4_HUMAN;sp|Q9NW64|RBM22_HUMAN;tr|E5RHA8|E5RHA8_HUMAN",4510,"E5RJW4","E5RJW4_HUMAN",null,null,"RBM22"]
["18.991","18.2425","19.19","16.5648",{"$nulls":3},"DNA metabolic process","actin filament binding;ATP binding;DNA binding;DNA-dependent ATPase activity;motor activity","myosin complex",{"$nulls":3},29,29,29,"20.1","20.1","20.1","231.1",0,"118.35",434130000,70,"0.192255",1,"0.73937","0.541687","tr|A0A0D9SFK2|A0A0D9SFK2_HUMAN;sp|Q92614|MY18A_HUMAN;tr|H0YEV9|H0YEV9_HUMAN","tr|A0A0D9SFK2|A0A0D9SFK2_HUMAN;sp|Q92614|MY18A_HUMAN",3507,"A0A0D9SFK2","A0A0D9SFK2_HUMAN",null,null,"MYO18A"]
["18.1739","17.4525","17.4373","16.7129",{"$nulls":3},"actin cytoskeleton organization;activation of protein kinase activity;apoptotic process;cell cycle;cell growth;cell migration;cell proliferation;cellular response to organic cyclic compound;cytoskeleton organization;dendritic spine development;movement of cell or subcellular component;negative regulation of endothelial cell apoptotic process;positive regulation of angiogenesis;regulation of apoptotic process;regulation of MAPK cascade;regulation of mitotic cell cycle;Rho protein signal transduction;signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;cadherin binding involved in cell-cell adhesion;protein kinase activity;protein serine/threonine kinase activity;Rac GTPase binding","cell-cell adherens junction;focal adhesion;Golgi apparatus","Axon guidance;ErbB signaling pathway;Focal adhesion;Human immunodeficiency virus 1 infection;MicroRNAs in cancer;Ras signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway",null,null,2,2,2,"4.4","4.4","4.4","64.071",0,"25.083",45470000,8,"0.544279",1,"0.73811","1.44395","sp|O96013|PAK4_HUMAN;tr|M0R2X4|M0R2X4_HUMAN","sp|O96013|PAK4_HUMAN;tr|M0R2X4|M0R2X4_HUMAN",790,"O96013","PAK4_HUMAN","Serine/threonine-protein kinase PAK 4",null,"PAK4"]
[1,"16.947","15.4731",1,{"$nulls":3},"cellular response to leukemia inhibitory factor;positive regulation of gene expression, epigenetic;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription initiation from RNA polymerase I promoter","DNA-directed 5'-3' RNA polymerase activity","DNA-directed RNA polymerase I complex;nucleoplasm","RNA polymerase",null,null,9,9,9,"29.6","29.6","29.6","37.432",0,"54.975",361620000,51,"0.0215166",1,"0.736925","0.0684383","sp|Q3B726|RPA43_HUMAN","sp|Q3B726|RPA43_HUMAN",2612,"Q3B726","RPA43_HUMAN","DNA-directed RNA polymerase I subunit RPA43",null,"TWISTNB"]
["18.5448","19.7028","18.9232","17.8528",{"$nulls":3},"innate immune response;toll-like receptor signaling pathway","receptor binding","endoplasmic reticulum lumen",{"$nulls":3},1,1,1,"6.8","6.8","6.8","30.748",0,"16.362",71157000,8,"0.347512",1,"0.735782","0.933157","sp|Q9BT09|CNPY3_HUMAN","sp|Q9BT09|CNPY3_HUMAN",3956,"Q9BT09","CNPY3_HUMAN","Protein canopy homolog 3",null,"CNPY3"]
[1,"16.8584","15.3925",1,{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding","nuclear membrane;nucleoplasm;nucleus;precatalytic spliceosome","Spliceosome",null,null,7,7,7,"18.9","18.9","18.9","37.476",0,"13.738",47438000,12,"0.0215203",1,"0.732949","0.0684496","sp|Q8NAV1|PR38A_HUMAN","sp|Q8NAV1|PR38A_HUMAN",3274,"Q8NAV1","PR38A_HUMAN","Pre-mRNA-splicing factor 38A",null,"PRPF38A"]
["20.4116","20.549","20.3774","19.1185",{"$nulls":3},"microtubule anchoring;negative regulation of DNA binding transcription factor activity;negative regulation of protein binding;negative regulation of protein homotetramerization;negative regulation of transcription, DNA-templated;peroxisome organization;peroxisome transport along microtubule;protein complex assembly;protein homooligomerization;protein import into peroxisome matrix;protein import into peroxisome matrix, substrate release;protein import into peroxisome matrix, translocation","beta-tubulin binding;microtubule binding;protein N-terminus binding;receptor binding;transcription corepressor activity","fibrillar center;integral component of membrane;intracellular;membrane;nucleus;peroxisomal importomer complex;peroxisomal membrane;peroxisome;protein complex","Peroxisome",null,null,7,7,7,"37.9","37.9","37.9","41.236",0,"40.899",153950000,29,"0.435427",1,"0.732356","1.1566","sp|O75381|PEX14_HUMAN","sp|O75381|PEX14_HUMAN",558,"O75381","PEX14_HUMAN","Peroxisomal membrane protein PEX14",null,"PEX14"]
["21.0253","21.8623","20.8925","20.5336",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;regulation of alternative mRNA splicing, via spliceosome;regulation of translation;RNA export from nucleus;termination of RNA polymerase II transcription","mRNA binding;RNA binding","catalytic step 2 spliceosome;cytoplasm;cytosol;dendrite;exon-exon junction complex;neuronal cell body;nuclear speck;nucleoplasm;nucleus","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,4,4,4,"36.8","36.8","36.8","19.889",0,"28.585",119800000,4,"0.6025",1,"0.730752","1.60481","sp|Q9Y5S9|RBM8A_HUMAN;tr|A0A0J9YW13|A0A0J9YW13_HUMAN","sp|Q9Y5S9|RBM8A_HUMAN;tr|A0A0J9YW13|A0A0J9YW13_HUMAN",5054,"Q9Y5S9","RBM8A_HUMAN","RNA-binding protein 8A",null,"RBM8A"]
["18.9234","20.4799","19.285","18.6575",{"$nulls":3},"endocytosis;intracellular protein transport;negative regulation of epidermal growth factor-activated receptor activity;negative regulation of transcription, DNA-templated;negative regulation of transforming growth factor beta receptor signaling pathway;regulation of macroautophagy;retrograde transport, endosome to Golgi;vesicle organization","dynactin binding;phosphatidylinositol binding;protein heterodimerization activity;protein homodimerization activity","cytoplasm;cytosol;early endosome membrane;extrinsic component of membrane;intracellular;nucleus;retromer complex;retromer, tubulation complex;tubular endosome","Endocytosis",null,null,10,9,9,"27.8","25.4","25.4","46.648",0,"16.43",115530000,25,"0.322566",1,"0.73044","0.870495","sp|Q9UNH7|SNX6_HUMAN;tr|A0A0A0MRI2|A0A0A0MRI2_HUMAN;tr|G3V5X9|G3V5X9_HUMAN;tr|H0YJF8|H0YJF8_HUMAN;tr|G3V4Z5|G3V4Z5_HUMAN;tr|G3V5U2|G3V5U2_HUMAN;sp|Q86XE0|SNX32_HUMAN","sp|Q9UNH7|SNX6_HUMAN;tr|A0A0A0MRI2|A0A0A0MRI2_HUMAN",4845,"Q9UNH7","SNX6_HUMAN","Sorting nexin-6",null,"SNX6"]
["18.4316","19.9433","18.2067","18.7076",{"$nulls":3},"apoptotic process",null,"Golgi membrane;integral component of membrane",{"$nulls":3},2,2,2,"28.1","28.1","28.1","17.132","0.00026413","7.5132",31358000,9,"0.341131",1,"0.730299","0.917112","tr|E9PND3|E9PND3_HUMAN;tr|E9PN10|E9PN10_HUMAN;sp|O00559|RCAS1_HUMAN;tr|E9PJ38|E9PJ38_HUMAN","tr|E9PND3|E9PND3_HUMAN;tr|E9PN10|E9PN10_HUMAN;sp|O00559|RCAS1_HUMAN;tr|E9PJ38|E9PJ38_HUMAN",241,"E9PND3","E9PND3_HUMAN","Receptor-binding cancer antigen expressed on SiSo cells {ECO:0000256|PIRNR:PIRNR034247}",null,"EBAG9"]
["20.6052","21.445","19.8815","20.7098",{"$nulls":3},"central nervous system development;signal transduction;synaptic vesicle uncoating","cadherin binding;GTPase binding;identical protein binding;lipid binding;phosphatase binding","cell junction;cell projection;cytoplasm;early endosome membrane;podosome;synapse","Endocytosis",null,null,10,10,10,31,31,31,"41.489",0,"20.57",274510000,21,"0.466402",1,"0.729459","1.23688","sp|Q99961|SH3G1_HUMAN;tr|M0QYE0|M0QYE0_HUMAN;tr|M0R0I3|M0R0I3_HUMAN;sp|Q99962|SH3G2_HUMAN;tr|M0R2K6|M0R2K6_HUMAN","sp|Q99961|SH3G1_HUMAN;tr|M0QYE0|M0QYE0_HUMAN;tr|M0R0I3|M0R0I3_HUMAN",3897,"Q99961","SH3G1_HUMAN","Endophilin-A2",null,"SH3GL1"]
["21.1146","21.9242","21.3591","20.2249",{"$nulls":4},"ATP binding;metal ion binding","nucleus",{"$nulls":3},75,75,75,"46.3","46.3","46.3","217.1",0,"323.31",10462000000,731,"0.391356",1,"0.727355","1.04392","tr|F5GWX5|F5GWX5_HUMAN;sp|Q14839|CHD4_HUMAN;tr|A0A0C4DGG9|A0A0C4DGG9_HUMAN;sp|Q8TDI0|CHD5_HUMAN;sp|Q12873|CHD3_HUMAN;tr|K7EMY3|K7EMY3_HUMAN;tr|F5H6N4|F5H6N4_HUMAN;tr|F2Z2R5|F2Z2R5_HUMAN;tr|I3L229|I3L229_HUMAN;tr|H7C3H7|H7C3H7_HUMAN;tr|H7C0J3|H7C0J3_HUMAN;tr|F5H596|F5H596_HUMAN","tr|F5GWX5|F5GWX5_HUMAN;sp|Q14839|CHD4_HUMAN;tr|A0A0C4DGG9|A0A0C4DGG9_HUMAN",5222,"F5GWX5","F5GWX5_HUMAN",null,null,"CHD4"]
["19.8997","19.9315","19.534","18.8439",{"$nulls":3},"activation of innate immune response;centriole assembly;DNA recombination;DNA repair;DNA replication;glucocorticoid receptor signaling pathway;histone deacetylation;innate immune response;intracellular estrogen receptor signaling pathway;negative regulation of centriole replication;positive regulation of transcription from RNA polymerase II promoter;response to hormone;SMAD protein signal transduction;transcription, DNA-templated","ligand-dependent nuclear receptor transcription coactivator activity;protein binding, bridging;RNA binding;RNA polymerase II transcription cofactor activity","cytoplasm;intracellular ribonucleoprotein complex;mediator complex;nuclear speck;nucleolus;nucleoplasm;nucleus;transcription factor complex",{"$nulls":3},6,6,6,"12.7","12.7","12.7","69.491",0,"43.503",262240000,39,"0.769221",1,"0.726604","2.10342","sp|Q96PK6|RBM14_HUMAN","sp|Q96PK6|RBM14_HUMAN",3785,"Q96PK6","RBM14_HUMAN","RNA-binding protein 14",null,"RBM14"]
["20.2887","20.6077","20.4236","19.0202",{"$nulls":3},"COPII vesicle coating;ER to Golgi vesicle-mediated transport;Golgi organization;intracellular protein transport","metal ion binding;phospholipase activity;RNA binding","COPII-coated ER to Golgi transport vesicle;cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;ER to Golgi transport vesicle membrane;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle",{"$nulls":3},16,16,16,"21.4","21.4","21.4","111.08",0,"51.355",356800000,48,"0.377713",1,"0.726316","1.00934","sp|Q9Y6Y8|S23IP_HUMAN;tr|A0A0C4DH82|A0A0C4DH82_HUMAN;tr|H7C4C4|H7C4C4_HUMAN;tr|H7C0V8|H7C0V8_HUMAN","sp|Q9Y6Y8|S23IP_HUMAN",5121,"Q9Y6Y8","S23IP_HUMAN","SEC23-interacting protein",null,"SEC23IP"]
["20.6426","21.19","20.8801","19.5044",{"$nulls":3},"G-protein coupled receptor signaling pathway","glutathione binding;G-protein coupled receptor activity;low-density lipoprotein particle receptor binding;SH3 domain binding;zinc ion binding","cytoplasm;extracellular exosome;integral component of plasma membrane;plasma membrane",{"$nulls":3},5,5,5,14,14,14,"45.283",0,"12.842",210700000,20,"0.365344",1,"0.724087","0.978085","sp|O43813|LANC1_HUMAN;tr|E9PHS0|E9PHS0_HUMAN;tr|F8WDS9|F8WDS9_HUMAN","sp|O43813|LANC1_HUMAN;tr|E9PHS0|E9PHS0_HUMAN;tr|F8WDS9|F8WDS9_HUMAN",438,"O43813","LANC1_HUMAN","LanC-like protein 1",null,"LANCL1"]
[1,"17.357",1,"15.909",{"$nulls":3},"covalent chromatin modification;dendrite development;positive regulation of dendrite morphogenesis;positive regulation of transcription, DNA-templated;transcription, DNA-templated","transcription coactivator activity","condensed chromosome kinetochore;condensed nuclear chromosome, centromeric region;cytosol;kinetochore;nBAF complex;nuclear body;nucleus",{"$nulls":3},2,2,2,"5.1","5.1","5.1","42.99",0,"15.178",80291000,13,"0.0205492",1,"0.724015","0.0654268","sp|O75177|CREST_HUMAN","sp|O75177|CREST_HUMAN",536,"O75177","CREST_HUMAN","Calcium-responsive transactivator",null,"SS18L1"]
["14.9832","14.0231","14.2889","13.2775",{"$nulls":5},"centrosome;cytosol;nuclear membrane",{"$nulls":3},4,4,4,4,4,4,"171.97",0,"8.5031",58988000,17,"0.386873",1,"0.719975","1.03255","tr|H0Y2V6|H0Y2V6_HUMAN;sp|Q5SW79|CE170_HUMAN","tr|H0Y2V6|H0Y2V6_HUMAN;sp|Q5SW79|CE170_HUMAN",2715,"H0Y2V6","H0Y2V6_HUMAN",null,null,"CEP170"]
["20.6123","21.398","20.7249","19.8484",{"$nulls":3},"activation of GTPase activity;cell division;chromosome passenger complex localization to kinetochore;establishment of protein localization;focal adhesion assembly;integrin-mediated signaling pathway;negative regulation of focal adhesion assembly;negative regulation of GTPase activity;negative regulation of substrate adhesion-dependent cell spreading;positive regulation of attachment of spindle microtubules to kinetochore;positive regulation of G2/M transition of mitotic cell cycle;regulation of cell migration;regulation of fibroblast migration;regulation of ruffle assembly;sister chromatid cohesion","microtubule binding;protein domain specific binding;protein kinase binding;Rac GTPase binding;RNA binding;small GTPase binding","chromosome, centromeric core domain;cytosol;early endosome membrane;microtubule;midbody;mitotic spindle midzone;nucleolus;plasma membrane",{"$nulls":3},7,7,7,"23.4","23.4","23.4","56.084",0,"22.127",449010000,46,"0.460181",1,"0.718439","1.22067","sp|Q9P258|RCC2_HUMAN","sp|Q9P258|RCC2_HUMAN",4631,"Q9P258","RCC2_HUMAN","Protein RCC2",null,"RCC2"]
["15.6633","15.6871","14.6816","15.2319",{"$nulls":9},8,8,8,"11.3","11.3","11.3",110,0,"18.304",122530000,18,"0.917617",1,"0.718413","2.6085","tr|Q5VWU8|Q5VWU8_HUMAN;tr|Q5VWV2|Q5VWV2_HUMAN;sp|Q8TEW0|PARD3_HUMAN;tr|F5GZI3|F5GZI3_HUMAN;tr|B1AP52|B1AP52_HUMAN","tr|Q5VWU8|Q5VWU8_HUMAN;tr|Q5VWV2|Q5VWV2_HUMAN;sp|Q8TEW0|PARD3_HUMAN;tr|F5GZI3|F5GZI3_HUMAN",3401,"Q5VWU8","Q5VWU8_HUMAN",null,null,"PARD3"]
["20.1152","21.1291","20.1641","19.6444",{"$nulls":3},"actin filament-based movement;actomyosin structure organization;mitochondrion morphogenesis;neuronal action potential;regulation of cell shape;sensory perception of sound;skeletal muscle contraction;skeletal muscle tissue development;vocalization behavior","actin filament binding;actin-dependent ATPase activity;ATP binding;ATPase activity;calmodulin binding;microfilament motor activity","actomyosin;axon;brush border;cytosol;extracellular exosome;growth cone;membrane;myelin sheath;myosin II complex;myosin II filament;stress fiber","Regulation of actin cytoskeleton;Tight junction",null,null,67,59,40,"38.3","34.9","23.6","227.87",0,"323.31",3157000000,256,"0.475285",1,"0.717873","1.2601","sp|Q7Z406|MYH14_HUMAN;tr|A1L2Z2|A1L2Z2_HUMAN;tr|A0A0C4DFM8|A0A0C4DFM8_HUMAN","sp|Q7Z406|MYH14_HUMAN",2996,"Q7Z406","MYH14_HUMAN","Myosin-14",null,"MYH14"]
["21.9902","23.6453","22.0698","22.1305",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},8,8,8,"51.1","51.1","51.1","16.714",0,"48.744",1085300000,82,"0.320978",1,"0.717566","0.866511","tr|M0R3D6|M0R3D6_HUMAN;tr|M0R1A7|M0R1A7_HUMAN;tr|M0R117|M0R117_HUMAN;sp|Q02543|RL18A_HUMAN;tr|M0R0P7|M0R0P7_HUMAN","tr|M0R3D6|M0R3D6_HUMAN;tr|M0R1A7|M0R1A7_HUMAN;tr|M0R117|M0R117_HUMAN;sp|Q02543|RL18A_HUMAN;tr|M0R0P7|M0R0P7_HUMAN",2068,"M0R3D6","M0R3D6_HUMAN",null,null,"RPL18A"]
["16.1827","16.5262","16.3174","14.9668",{"$nulls":9},4,4,4,"6.9","6.9","6.9","114.43","0.0006795","4.3443",41416000,5,"0.382867",1,"0.712391","1.02239","tr|A0A087WW77|A0A087WW77_HUMAN;sp|Q15334|L2GL1_HUMAN","tr|A0A087WW77|A0A087WW77_HUMAN;sp|Q15334|L2GL1_HUMAN",2472,"A0A087WW77","A0A087WW77_HUMAN",null,null,"LLGL1"]
["16.8559","18.1446","17.2892","16.2872",{"$nulls":3},"cytoskeleton organization;positive regulation of translation;regulation of cell morphogenesis;translation","poly(A) binding;RNA binding","cytosol;membrane",{"$nulls":3},7,7,7,"15.2","15.2","15.2","80.595","0.0002611","7.2834",50272000,7,"0.323328",1,"0.712076","0.872408","sp|Q71RC2|LARP4_HUMAN;tr|X6RLN4|X6RLN4_HUMAN;tr|Q96J85|Q96J85_HUMAN;tr|Q8TBL5|Q8TBL5_HUMAN;tr|A0A087WTL9|A0A087WTL9_HUMAN;tr|Q6P4E2|Q6P4E2_HUMAN","sp|Q71RC2|LARP4_HUMAN;tr|X6RLN4|X6RLN4_HUMAN",2951,"Q71RC2","LARP4_HUMAN","La-related protein 4",null,"LARP4"]
["20.1304","19.8853","19.6355","18.9586",{"$nulls":3},"endoplasmic reticulum organization;positive regulation of ATPase activity;protein localization to nuclear envelope","ATPase activator activity;ATPase binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;nuclear membrane",{"$nulls":3},8,8,8,"25.5","25.5","25.5","51.263",0,"54.427",210030000,27,"0.728189",1,"0.710858","1.97473","sp|Q8NFQ8|TOIP2_HUMAN","sp|Q8NFQ8|TOIP2_HUMAN",3341,"Q8NFQ8","TOIP2_HUMAN","Torsin-1A-interacting protein 2",null,"TOR1AIP2"]
[1,"19.7344",1,"18.3131",{"$nulls":3},"cardiac muscle tissue morphogenesis;cellular iron ion homeostasis;heart trabecula formation;labyrinthine layer development;negative regulation of cAMP catabolic process;negative regulation of cyclic-nucleotide phosphodiesterase activity;negative regulation of DNA binding transcription factor activity;oxygen homeostasis;peptidyl-proline hydroxylation to 4-hydroxy-L-proline;positive regulation of transcription from RNA polymerase II promoter;regulation of angiogenesis;regulation of neuron death;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to hypoxia;response to nitric oxide;ventricular septum morphogenesis","enzyme binding;iron ion binding;L-ascorbic acid binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;peptidyl-proline 4-dioxygenase activity;peptidyl-proline dioxygenase activity","cytoplasm;cytosol;nucleus","HIF-1 signaling pathway;Pathways in cancer;Renal cell carcinoma",null,null,4,4,4,"11.3","11.3","11.3","46.02",0,"8.8312",51626000,6,"0.0174427",1,"0.710651","0.0557172","sp|Q9GZT9|EGLN1_HUMAN","sp|Q9GZT9|EGLN1_HUMAN",4119,"Q9GZT9","EGLN1_HUMAN","Egl nine homolog 1",null,"EGLN1"]
["21.6049","21.6777","21.3575","20.5074",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,2,2,2,"12.1","12.1","12.1","33.3",0,"73.572",142390000,2,"0.622551",1,"0.708848","1.66161","sp|Q5T653|RM02_HUMAN;tr|C9IY40|C9IY40_HUMAN","sp|Q5T653|RM02_HUMAN;tr|C9IY40|C9IY40_HUMAN",2732,"Q5T653","RM02_HUMAN","39S ribosomal protein L2, mitochondrial","2mt;RP-L2","MRPL2"]
["18.6835","18.744","18.5982","17.4125",{"$nulls":3},"dopamine receptor signaling pathway;transcription, DNA-templated","metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nucleus",{"$nulls":3},2,2,2,"17.1","17.1","17.1","25.43",0,"27.501",173820000,32,"0.449614",1,"0.708383","1.19324","sp|Q9BXK1|KLF16_HUMAN","sp|Q9BXK1|KLF16_HUMAN",4044,"Q9BXK1","KLF16_HUMAN","Krueppel-like factor 16",null,"KLF16"]
["23.6049","24.0314","23.9405","22.2805",{"$nulls":4},"RNA binding","mitochondrion",{"$nulls":3},6,6,6,"65.2","65.2","65.2","10.353",0,"41.125",780490000,51,"0.304738",1,"0.707659","0.825791","tr|A0A087WUN7|A0A087WUN7_HUMAN;tr|H0YJ40|H0YJ40_HUMAN;tr|G3V4X6|G3V4X6_HUMAN;sp|Q9GZT3|SLIRP_HUMAN;tr|G3V2S9|G3V2S9_HUMAN;tr|H0YJW7|H0YJW7_HUMAN;tr|H0YJ07|H0YJ07_HUMAN;tr|H0YJU7|H0YJU7_HUMAN;tr|H0YJI1|H0YJI1_HUMAN","tr|A0A087WUN7|A0A087WUN7_HUMAN;tr|H0YJ40|H0YJ40_HUMAN;tr|G3V4X6|G3V4X6_HUMAN;sp|Q9GZT3|SLIRP_HUMAN;tr|G3V2S9|G3V2S9_HUMAN;tr|H0YJW7|H0YJW7_HUMAN;tr|H0YJ07|H0YJ07_HUMAN;tr|H0YJU7|H0YJU7_HUMAN",4116,"A0A087WUN7","A0A087WUN7_HUMAN",null,null,"SLIRP"]
["18.8041","19.4966","18.8105","18.0778",{"$nulls":3},"base-excision repair","alkylbase DNA N-glycosylase activity;DNA binding","integral component of membrane",{"$nulls":3},4,4,4,"21.5","21.5","21.5","27.295",0,"13.437",59041000,8,"0.528427",1,"0.706226","1.40111","tr|A2IDA3|A2IDA3_HUMAN;sp|P29372|3MG_HUMAN","tr|A2IDA3|A2IDA3_HUMAN;sp|P29372|3MG_HUMAN",1284,"A2IDA3","A2IDA3_HUMAN"]
["19.0248","20.8731","19.5752","18.9152",{"$nulls":4},"metal ion binding","integral component of membrane",{"$nulls":3},1,1,1,"12.2","12.2","12.2","12.976",0,"11.359",18987000,7,"0.261433",1,"0.703711","0.717142","tr|E9PP55|E9PP55_HUMAN;sp|Q96K19|RN170_HUMAN","tr|E9PP55|E9PP55_HUMAN;sp|Q96K19|RN170_HUMAN",3750,"E9PP55","E9PP55_HUMAN",null,null,"RNF170"]
[1,"19.2689",1,"17.8653",{"$nulls":9},10,2,2,"55.2","14.6","14.6","22.692",0,"105.75",278590000,17,"0.0176773",1,"0.701802","0.0564524","tr|B1ALG6|B1ALG6_HUMAN","tr|B1ALG6|B1ALG6_HUMAN",5168,"B1ALG6","B1ALG6_HUMAN",null,null,"HELLS"]
["22.4658","22.6403","22.063","21.6408",{"$nulls":3},"signal transduction","protein phosphatase inhibitor activity",{"$nulls":4},3,3,3,41,41,41,"16.619",0,"19.243",261300000,21,"1.03736",1,"0.701117","3.0696","tr|J3KSJ8|J3KSJ8_HUMAN;sp|Q9UD71|PPR1B_HUMAN;tr|J3KT77|J3KT77_HUMAN","tr|J3KSJ8|J3KSJ8_HUMAN;sp|Q9UD71|PPR1B_HUMAN;tr|J3KT77|J3KT77_HUMAN",4686,"J3KSJ8","J3KSJ8_HUMAN",null,null,"PPP1R1B"]
["19.7278","18.5694","19.3219","17.577",{"$nulls":3},"glutamyl-tRNA aminoacylation","ATP binding;glutamate-tRNA ligase activity;tRNA binding;zinc ion binding","cytoplasm",{"$nulls":3},7,7,7,"17.2","17.2","17.2","56.825",0,"15.43",186220000,14,"0.24177",1,"0.69917","0.66762","tr|H3BTB7|H3BTB7_HUMAN;sp|Q5JPH6|SYEM_HUMAN","tr|H3BTB7|H3BTB7_HUMAN;sp|Q5JPH6|SYEM_HUMAN",2693,"H3BTB7","H3BTB7_HUMAN",null,null,"EARS2"]
["20.1337","21.2831","20.1559","19.8639",{"$nulls":3},"lipid particle organization;neutrophil degranulation;response to unfolded protein;retrograde protein transport, ER to cytosol;ubiquitin-dependent ERAD pathway","lipase binding;lipase inhibitor activity;ubiquitin binding;ubiquitin protein ligase binding","azurophil granule lumen;endoplasmic reticulum;extracellular region;lipid droplet;VCP-NPL4-UFD1 AAA ATPase complex",{"$nulls":3},7,7,7,"22.5","22.5","22.5","52.623",0,"108.23",419030000,39,"0.443737",1,"0.698536","1.17804","sp|Q96CS3|FAF2_HUMAN","sp|Q96CS3|FAF2_HUMAN",3640,"Q96CS3","FAF2_HUMAN","FAS-associated factor 2",null,"FAF2"]
["17.8694","17.3747","16.8849","16.9634",{"$nulls":3},"mRNA 5'-splice site recognition",null,"commitment complex;U1 snRNP;U2-type prespliceosome",{"$nulls":3},2,2,2,4,4,4,"78.429","0.00068353","4.4269",37865000,7,"0.965477",1,"0.697865","2.78648","sp|Q86UA1|PRP39_HUMAN;tr|H0YJY9|H0YJY9_HUMAN","sp|Q86UA1|PRP39_HUMAN;tr|H0YJY9|H0YJY9_HUMAN",3045,"Q86UA1","PRP39_HUMAN","Pre-mRNA-processing factor 39",null,"PRPF39"]
[1,"19.808",1,"18.4163",{"$nulls":3},"arginyl-tRNA aminoacylation","arginine-tRNA ligase activity;ATP binding","cytoplasm","Spliceosome",null,null,2,2,2,"20.5","20.5","20.5","19.181",0,"10.577",36186000,7,"0.0169882",1,"0.695836","0.0542914","sp|Q8WUD4|CCD12_HUMAN;tr|J3KR35|J3KR35_HUMAN;tr|S4R331|S4R331_HUMAN;tr|C9JUN5|C9JUN5_HUMAN","sp|Q8WUD4|CCD12_HUMAN;tr|J3KR35|J3KR35_HUMAN;tr|S4R331|S4R331_HUMAN;tr|C9JUN5|C9JUN5_HUMAN",3419,"Q8WUD4","CCD12_HUMAN","Coiled-coil domain-containing protein 12",null,"CCDC12"]
["18.3221","17.1486","17.9901","16.091",{"$nulls":3},"positive regulation of rRNA processing;rRNA methylation","18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity;RNA binding;rRNA (adenine-N6,N6-)-dimethyltransferase activity","cytosol;mitochondrial matrix;nucleolus;nucleoplasm;nucleus",{"$nulls":3},8,8,8,"34.5","34.5","34.5","35.236",0,"13.97",135950000,15,"0.223919",1,"0.694814","0.622465","sp|Q9UNQ2|DIM1_HUMAN;tr|A0A0C4DGB1|A0A0C4DGB1_HUMAN;tr|D6RCL3|D6RCL3_HUMAN","sp|Q9UNQ2|DIM1_HUMAN;tr|A0A0C4DGB1|A0A0C4DGB1_HUMAN",4852,"Q9UNQ2","DIM1_HUMAN","Probable dimethyladenosine transferase",null,"DIMT1"]
["18.9217","17.688","18.0404","17.1801",{"$nulls":4},"metal ion binding;RNA binding",{"$nulls":4},7,7,7,"11.1","11.1","11.1","140.26",0,"14.43",118090000,23,"0.343738",1,"0.694608","0.923665","sp|Q9UPT8|ZC3H4_HUMAN;tr|M0QY97|M0QY97_HUMAN","sp|Q9UPT8|ZC3H4_HUMAN;tr|M0QY97|M0QY97_HUMAN",4871,"Q9UPT8","ZC3H4_HUMAN","Zinc finger CCCH domain-containing protein 4",null,"ZC3H4"]
["19.8914","18.6039","19.706","17.4049",{"$nulls":3},"cellular localization;early endosome to recycling endosome transport;forebrain development;negative regulation of phosphatase activity","actin filament binding;actin-dependent ATPase activity;ATP binding;calcium-dependent protein binding;calmodulin binding;microfilament motor activity;protein domain specific binding","apical dendrite;axolemma;axon;basolateral plasma membrane;brush border;cytoplasmic vesicle;cytosol;endosome;extracellular exosome;myelin sheath;myosin complex;neuron projection;neuronal cell body;plasma membrane raft;smooth endoplasmic reticulum",{"$nulls":3},44,44,44,"52.5","52.5","52.5","116.2",0,"246.33",3216300000,245,"0.185787",1,"0.692204","0.525047","sp|O94832|MYO1D_HUMAN;tr|J3QRN6|J3QRN6_HUMAN;tr|K7EIG7|K7EIG7_HUMAN;tr|J3KRL0|J3KRL0_HUMAN;tr|J3QRR2|J3QRR2_HUMAN;tr|F8WEW9|F8WEW9_HUMAN;sp|B0I1T2|MYO1G_HUMAN","sp|O94832|MYO1D_HUMAN;tr|J3QRN6|J3QRN6_HUMAN;tr|K7EIG7|K7EIG7_HUMAN",656,"O94832","MYO1D_HUMAN","Unconventional myosin-Id",null,"MYO1D"]
["19.2396","19.0254","19.0033","17.8826",{"$nulls":3},"mitochondrial respiratory chain complex I assembly;mitochondrial respiratory chain complex IV assembly;protein import into mitochondrial matrix",null,"integral component of membrane;mitochondrial inner membrane presequence translocase complex",{"$nulls":3},5,5,5,"21.8","21.8","21.8","28.202",0,"12.893",292460000,30,"0.455554",1,"0.689536","1.20865","sp|Q9BVV7|TIM21_HUMAN;tr|J3QRI1|J3QRI1_HUMAN;tr|J3KRJ3|J3KRJ3_HUMAN","sp|Q9BVV7|TIM21_HUMAN;tr|J3QRI1|J3QRI1_HUMAN",4018,"Q9BVV7","TIM21_HUMAN","Mitochondrial import inner membrane translocase subunit Tim21",null,"TIMM21"]
["19.063","19.7602","19.3328","18.1114",{"$nulls":3},"exocyst assembly;Golgi to plasma membrane transport;protein transport;regulation of entry of bacterium into host cell","protein kinase binding;protein N-terminus binding;Ral GTPase binding","cytosol;exocyst;Flemming body;membrane;plasma membrane","Ras signaling pathway",null,null,32,32,32,"38.5","38.5","38.5","104.07",0,"231.89",2839300000,233,"0.366279",1,"0.689443","0.980446","sp|Q96KP1|EXOC2_HUMAN;tr|Q2MDF5|Q2MDF5_HUMAN","sp|Q96KP1|EXOC2_HUMAN",3759,"Q96KP1","EXOC2_HUMAN","Exocyst complex component 2",null,"EXOC2"]
[1,"18.1043",1,"16.7273",{"$nulls":3},"chromatin remodeling;DNA methylation;DNA repair;histone H2A acetylation;histone H4 acetylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of transcription factor import into nucleus;regulation of growth;response to ethanol;transcription, DNA-templated","RNA polymerase II repressing transcription factor binding;transcription corepressor activity","cytoplasm;cytosol;NuA4 histone acetyltransferase complex;nucleoplasm;nucleus;replication fork",{"$nulls":3},8,8,8,"24.8","24.8","24.8","52.992",0,"15.405",129130000,24,"0.0185742",1,"0.688489","0.0592608","sp|Q9NPF5|DMAP1_HUMAN;tr|Q5TG40|Q5TG40_HUMAN;tr|Q5TG38|Q5TG38_HUMAN;tr|Q5TG39|Q5TG39_HUMAN;tr|Q5TG36|Q5TG36_HUMAN;tr|Q5TG37|Q5TG37_HUMAN","sp|Q9NPF5|DMAP1_HUMAN;tr|Q5TG40|Q5TG40_HUMAN;tr|Q5TG38|Q5TG38_HUMAN;tr|Q5TG39|Q5TG39_HUMAN",4367,"Q9NPF5","DMAP1_HUMAN","DNA methyltransferase 1-associated protein 1","NMAP1;NMT1-associated protein 1","DMAP1"]
["15.8894","14.4944","16.9513","12.0612",{"$nulls":3},"cell differentiation;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;intraciliary transport involved in cilium assembly;multicellular organism development;positive regulation of cell proliferation;positive regulation of intracellular protein transport;protein localization to centrosome;regulation of centrosome duplication;regulation of G2/M transition of mitotic cell cycle;spermatogenesis","protein complex binding;protein homodimerization activity","acrosomal vesicle;centriolar satellite;centrosome;ciliary transition zone;cytosol;intercellular bridge;intracellular membrane-bounded organelle;microtubule cytoskeleton;microtubule organizing center",{"$nulls":3},16,16,16,"18.4","18.4","18.4","122.15",0,"40.109",271590000,44,"0.0900705",1,"0.685622","0.269656","sp|Q9UPN4|CP131_HUMAN;tr|I3L2J8|I3L2J8_HUMAN;tr|I3L2X7|I3L2X7_HUMAN;tr|I3L316|I3L316_HUMAN;tr|I3L4M5|I3L4M5_HUMAN","sp|Q9UPN4|CP131_HUMAN;tr|I3L2J8|I3L2J8_HUMAN",4862,"Q9UPN4","CP131_HUMAN","Centrosomal protein of 131 kDa",null,"CEP131"]
["18.2402","17.8119","18.0557","16.6269",{"$nulls":5},"cytosol;intracellular membrane-bounded organelle;nucleolus;WASH complex",{"$nulls":3},12,12,12,"16.5","16.5","16.5","136.86",0,"38.896",141680000,28,"0.341554",1,"0.684799","0.918173","tr|F8W7U3|F8W7U3_HUMAN;tr|E7ESD2|E7ESD2_HUMAN;sp|Q641Q2|FA21A_HUMAN;tr|A0A087WYF6|A0A087WYF6_HUMAN;tr|J3KP36|J3KP36_HUMAN;sp|Q9Y4E1|FA21C_HUMAN;tr|A0A0A0MR88|A0A0A0MR88_HUMAN;tr|A0A096LPC5|A0A096LPC5_HUMAN;tr|B1AP61|B1AP61_HUMAN;tr|A0A0A0MT65|A0A0A0MT65_HUMAN;sp|Q5SRD0|FA21D_HUMAN","tr|F8W7U3|F8W7U3_HUMAN;tr|E7ESD2|E7ESD2_HUMAN;sp|Q641Q2|FA21A_HUMAN;tr|A0A087WYF6|A0A087WYF6_HUMAN;tr|J3KP36|J3KP36_HUMAN;sp|Q9Y4E1|FA21C_HUMAN;tr|A0A0A0MR88|A0A0A0MR88_HUMAN;tr|A0A096LPC5|A0A096LPC5_HUMAN",2781,"F8W7U3","F8W7U3_HUMAN",null,null,"WASHC2A"]
["16.7675","15.4353","15.8134","15.0233",{"$nulls":3},"aging;behavioral response to cocaine;cerebellum development;copulation;exploration behavior;gamma-aminobutyric acid biosynthetic process;gamma-aminobutyric acid catabolic process;locomotory behavior;negative regulation of blood pressure;negative regulation of dopamine secretion;negative regulation of gamma-aminobutyric acid secretion;negative regulation of platelet aggregation;neurotransmitter catabolic process;positive regulation of aspartate secretion;positive regulation of dopamine metabolic process;positive regulation of heat generation;positive regulation of inhibitory postsynaptic potential;positive regulation of insulin secretion;positive regulation of prolactin secretion;positive regulation of uterine smooth muscle contraction;response to drug;response to ethanol;response to hypoxia;response to iron ion;response to nicotine","(S)-3-amino-2-methylpropionate transaminase activity;4-aminobutyrate transaminase activity;4-aminobutyrate:2-oxoglutarate transaminase activity;iron-sulfur cluster binding;metal ion binding;protein homodimerization activity;pyridoxal phosphate binding;succinate-semialdehyde dehydrogenase binding","4-aminobutyrate transaminase complex;extracellular exosome;mitochondrial matrix;mitochondrion;neuron projection","Alanine, aspartate and glutamate metabolism;beta-Alanine metabolism;Butanoate metabolism;GABAergic synapse;Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,2,2,2,5,5,5,"56.438","0.0015025","3.5582",18701000,4,"0.327147",1,"0.683023","0.88199","sp|P80404|GABT_HUMAN;tr|H3BRN4|H3BRN4_HUMAN;tr|H3BNQ7|H3BNQ7_HUMAN;tr|H3BRJ1|H3BRJ1_HUMAN;tr|H3BMJ9|H3BMJ9_HUMAN;tr|H3BRT1|H3BRT1_HUMAN;tr|H3BPW8|H3BPW8_HUMAN","sp|P80404|GABT_HUMAN;tr|H3BRN4|H3BRN4_HUMAN;tr|H3BNQ7|H3BNQ7_HUMAN;tr|H3BRJ1|H3BRJ1_HUMAN;tr|H3BMJ9|H3BMJ9_HUMAN;tr|H3BRT1|H3BRT1_HUMAN;tr|H3BPW8|H3BPW8_HUMAN",1985,"P80404","GABT_HUMAN","4-aminobutyrate aminotransferase, mitochondrial",null,"ABAT"]
["17.6137","16.3011","17.8404","14.7098",{"$nulls":3},"cell division;miRNA catabolic process;mitotic cell cycle;mitotic sister chromatid separation;negative regulation of cell proliferation;nuclear-transcribed mRNA catabolic process, exonucleolytic;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';polyuridylation-dependent mRNA catabolic process;rRNA processing;stem cell population maintenance","3'-5'-exoribonuclease activity;magnesium ion binding;poly(U) RNA binding;ribonuclease activity","cytoplasm;exosome (RNase complex);P-body;polysome",{"$nulls":3},5,5,5,"6.6","6.6","6.6","99.278",0,"11.101",68232000,6,"0.138719",1,"0.682317","0.401998","sp|Q8IYB7|DI3L2_HUMAN;tr|H7C440|H7C440_HUMAN;tr|C9JGP4|C9JGP4_HUMAN","sp|Q8IYB7|DI3L2_HUMAN;tr|H7C440|H7C440_HUMAN",3163,"Q8IYB7","DI3L2_HUMAN","DIS3-like exonuclease 2 {ECO:0000255|HAMAP-Rule:MF_03045}","DIS3L2","DIS3L2"]
["21.2936","21.6457","21.2815","20.294",{"$nulls":3},"liver development;mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;negative regulation of DNA damage checkpoint;positive regulation of cell growth involved in cardiac muscle cell development;positive regulation of DNA biosynthetic process;positive regulation of DNA-templated transcription, elongation;positive regulation of translation;positive regulation of vascular smooth muscle cell proliferation;RNA export from nucleus;RNA secondary structure unwinding;RNA splicing;spliceosomal complex assembly;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus","ATP binding;ATPase activity;ATP-dependent protein binding;ATP-dependent RNA helicase activity;identical protein binding;protein complex binding;RNA binding;RNA-dependent ATPase activity;U4 snRNA binding;U6 snRNA binding","cytoplasm;nuclear matrix;nuclear speck;nucleolus;nucleoplasm;nucleus;spliceosomal complex;transcription export complex","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,13,4,4,"33.6","14.5","14.5","48.991",0,"25.377",413650000,23,"0.490777",1,"0.6819","1.30082","sp|Q13838|DX39B_HUMAN;tr|Q5STU3|Q5STU3_HUMAN;tr|F6WLT2|F6WLT2_HUMAN;tr|F6S4E6|F6S4E6_HUMAN;tr|A0A0A0MT12|A0A0A0MT12_HUMAN;tr|F6TRA5|F6TRA5_HUMAN;tr|A0A0G2JJZ9|A0A0G2JJZ9_HUMAN;tr|F6R6M7|F6R6M7_HUMAN;tr|F6UJC5|F6UJC5_HUMAN;tr|A0A0G2JHN7|A0A0G2JHN7_HUMAN;tr|F6U6E2|F6U6E2_HUMAN;tr|F6S2B7|F6S2B7_HUMAN;tr|F6QYI9|F6QYI9_HUMAN;tr|A0A0G2JJL7|A0A0G2JJL7_HUMAN;tr|H0Y400|H0Y400_HUMAN","sp|Q13838|DX39B_HUMAN;tr|Q5STU3|Q5STU3_HUMAN;tr|F6WLT2|F6WLT2_HUMAN;tr|F6S4E6|F6S4E6_HUMAN;tr|A0A0A0MT12|A0A0A0MT12_HUMAN;tr|F6TRA5|F6TRA5_HUMAN;tr|A0A0G2JJZ9|A0A0G2JJZ9_HUMAN",2308,"Q13838","DX39B_HUMAN","Spliceosome RNA helicase DDX39B",null,"DDX39B"]
["22.9819","21.8551","21.395","22.079",{"$nulls":3},"B cell activation;cell proliferation;exocytosis","cytokine activity;high molecular weight B cell growth factor receptor binding;syntaxin binding","cytoplasm;cytosol;extracellular region;membrane",{"$nulls":3},27,27,27,"52.7","52.7","52.7","61.89",0,"256.31",5085100000,298,"0.387467",1,"0.68152","1.03406","sp|P40222|TXLNA_HUMAN","sp|P40222|TXLNA_HUMAN",1436,"P40222","TXLNA_HUMAN","Alpha-taxilin",null,"TXLNA"]
["17.4774","17.8216","16.7399","17.1964",{"$nulls":3},"generation of neurons;mRNA 3'-end processing;mRNA export from nucleus;neuron development;poly(A)+ mRNA export from nucleus;RNA export from nucleus;RNA splicing;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus","mRNA binding","nuclear speck;nucleoplasm;THO complex;THO complex part of transcription export complex;transcription export complex","RNA transport;Spliceosome",null,null,29,29,29,"22.3","22.3","22.3","182.77",0,"103.57",1700500000,190,"0.853834",1,"0.681344","2.38325","sp|Q8NI27|THOC2_HUMAN;tr|A0A0C4DG98|A0A0C4DG98_HUMAN;tr|H0Y815|H0Y815_HUMAN;tr|H0Y7U4|H0Y7U4_HUMAN;tr|B7ZBA0|B7ZBA0_HUMAN;tr|H0Y594|H0Y594_HUMAN;tr|F2Z2V2|F2Z2V2_HUMAN;tr|H7C477|H7C477_HUMAN;tr|B7ZB98|B7ZB98_HUMAN","sp|Q8NI27|THOC2_HUMAN;tr|A0A0C4DG98|A0A0C4DG98_HUMAN",3351,"Q8NI27","THOC2_HUMAN","THO complex subunit 2","ho2","THOC2"]
["13.7935","16.3368","13.7208","15.0525",{"$nulls":3},"actin filament organization;anatomical structure morphogenesis;cell adhesion;cell migration;cell-cell adhesion;cell-cell signaling;establishment or maintenance of cell polarity;homophilic cell adhesion via plasma membrane adhesion molecules","calcium ion binding","cell-cell junction;extracellular exosome;filopodium;focal adhesion;integral component of plasma membrane;lamellipodium;nucleus;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},9,9,9,"2.5","2.5","2.5","506.27",0,"13.862",52673000,9,"0.16558",1,"0.678518","0.472685","sp|Q14517|FAT1_HUMAN;tr|A0A087WVP1|A0A087WVP1_HUMAN;tr|D6RCE4|D6RCE4_HUMAN","sp|Q14517|FAT1_HUMAN;tr|A0A087WVP1|A0A087WVP1_HUMAN",2365,"Q14517","FAT1_HUMAN","Protocadherin Fat 1",null,"FAT1"]
["21.5526","21.0812","21.7007","19.5768",{"$nulls":4},"GTP binding",{"$nulls":4},11,8,8,"34.9",27,27,"49.915",0,"37.067",367650000,26,"0.224314",1,"0.678195","0.623467","tr|A6NMH6|A6NMH6_HUMAN;sp|Q92599|SEPT8_HUMAN;tr|A0A087X142|A0A087X142_HUMAN;tr|A6NFQ9|A6NFQ9_HUMAN;tr|F8W8I8|F8W8I8_HUMAN;tr|A0A0A0MRP8|A0A0A0MRP8_HUMAN;tr|C9J4G8|C9J4G8_HUMAN;tr|C9JV02|C9JV02_HUMAN","tr|A6NMH6|A6NMH6_HUMAN;sp|Q92599|SEPT8_HUMAN;tr|A0A087X142|A0A087X142_HUMAN;tr|A6NFQ9|A6NFQ9_HUMAN;tr|F8W8I8|F8W8I8_HUMAN",3502,"A6NMH6","A6NMH6_HUMAN",null,null,"SEPT8"]
["20.2477","21.7422","20.28","20.3549",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;intracellular protein transport;receptor-mediated endocytosis;regulation of defense response to virus by virus;response to virus;retrograde transport, endosome to Golgi","protein transporter activity","AP-1 adaptor complex;clathrin-coated endocytic vesicle membrane;clathrin-coated pit;cytoplasmic vesicle membrane;cytosol;extracellular exosome;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle;lysosomal membrane;membrane;terminal bouton;trans-Golgi network membrane","Human immunodeficiency virus 1 infection;Lysosome",null,null,2,2,2,"15.8","15.8","15.8","18.733",0,"74.648",155940000,16,"0.336525",1,"0.677493","0.905537","sp|P61966|AP1S1_HUMAN;tr|H7C1E4|H7C1E4_HUMAN","sp|P61966|AP1S1_HUMAN;tr|H7C1E4|H7C1E4_HUMAN",1864,"P61966","AP1S1_HUMAN","AP-1 complex subunit sigma-1A",null,"AP1S1"]
["14.4817","17.593","15.2539","15.4698",{"$nulls":3},"intracellular estrogen receptor signaling pathway;regulation of transcription, DNA-templated;RNA metabolic process;RNA processing;RNA secondary structure unwinding;transcription, DNA-templated","ATP binding;ATP-dependent RNA helicase activity;estrogen receptor binding;receptor binding;RNA binding;transcription corepressor activity","cytoplasm;Golgi apparatus;membrane;nucleolus;nucleus",{"$nulls":3},19,19,19,"26.7","26.7","26.7","98.594",0,"158.86",622520000,65,"0.150508",1,"0.675502","0.433195","sp|Q8TDD1|DDX54_HUMAN;tr|H0YHH7|H0YHH7_HUMAN;tr|F8VRX4|F8VRX4_HUMAN;tr|H0YHZ9|H0YHZ9_HUMAN","sp|Q8TDD1|DDX54_HUMAN",3385,"Q8TDD1","DDX54_HUMAN","ATP-dependent RNA helicase DDX54",null,"DDX54"]
["20.2978","20.5552","19.6559","19.847",{"$nulls":3},"ER-associated misfolded protein catabolic process;error-free translesion synthesis;negative regulation of RIG-I signaling pathway;negative regulation of type I interferon production;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;retrograde protein transport, ER to cytosol;skeletal system development;ubiquitin-dependent protein catabolic process","ATPase binding;K48-linked polyubiquitin modification-dependent protein binding;protein complex binding;receptor binding;thiol-dependent ubiquitin-specific protease activity","cytosol;endoplasmic reticulum;nucleoplasm;nucleus;UFD1-NPL4 complex;VCP-NPL4-UFD1 AAA ATPase complex","Protein processing in endoplasmic reticulum",null,null,8,8,8,28,28,28,"34.5",0,"20.688",175980000,26,"1.28392",1,"0.675033","4.21196","sp|Q92890|UFD1_HUMAN;tr|C9J6N9|C9J6N9_HUMAN;tr|C9JNP9|C9JNP9_HUMAN;tr|C9IZG3|C9IZG3_HUMAN","sp|Q92890|UFD1_HUMAN",3547,"Q92890","UFD1_HUMAN","Ubiquitin recognition factor in ER-associated degradation protein 1 {ECO:0000312|HGNC:HGNC:12520}",null,"UFD1"]
["19.7774","21.3607","19.4649","20.3237",{"$nulls":3},"purine-containing compound salvage;pyrimidine nucleoside salvage;pyrimidine nucleotide metabolic process","ATP binding;deoxycytidine kinase activity;drug binding;nucleoside kinase activity;protein homodimerization activity","cytosol;nucleus","Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,9,9,9,"35.8","35.8","35.8","30.518",0,"88.058",187090000,21,"0.274209",1,"0.674765","0.749235","sp|P27707|DCK_HUMAN;tr|D6RFG8|D6RFG8_HUMAN;tr|D6RCP9|D6RCP9_HUMAN;tr|D6RG38|D6RG38_HUMAN","sp|P27707|DCK_HUMAN;tr|D6RFG8|D6RFG8_HUMAN;tr|D6RCP9|D6RCP9_HUMAN",1256,"P27707","DCK_HUMAN","Deoxycytidine kinase","CK","DCK"]
["24.3304","23.2664","24.0346","22.2149",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;calcium ion regulated exocytosis;cellular response to interferon-gamma;exocytosis;Golgi to plasma membrane protein transport;membrane fusion;membrane organization;negative regulation of secretion by cell;positive regulation of receptor recycling;protein complex assembly;retrograde transport, endosome to Golgi;SNARE complex assembly;substrate adhesion-dependent cell spreading;vesicle docking involved in exocytosis;vesicle fusion;vesicle-mediated transport","SNAP receptor activity;SNARE binding;syntaxin-1 binding","apical plasma membrane;cell junction;cell surface;clathrin-coated vesicle;clathrin-coated vesicle membrane;cytosol;integral component of membrane;intracellular;intracellular membrane-bounded organelle;neuron projection;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;recycling endosome;recycling endosome membrane;secretory granule;SNARE complex;synapse;trans-Golgi network membrane;transport vesicle","Phagosome;SNARE interactions in vesicular transport",null,null,5,5,4,53,53,29,"11.309",0,"124.64",673590000,26,"0.23052",1,"0.673665","0.63919","sp|Q15836|VAMP3_HUMAN;tr|K7ENK9|K7ENK9_HUMAN;tr|K7EKX0|K7EKX0_HUMAN","sp|Q15836|VAMP3_HUMAN",2529,"Q15836","VAMP3_HUMAN","Vesicle-associated membrane protein 3","AMP-3","VAMP3"]
["21.6154","21.8947","21.6118","20.5532",{"$nulls":3},"regulation of transcription, DNA-templated;response to hypoxia;response to oxidative stress","cadherin binding involved in cell-cell adhesion;metal ion binding;transcription coactivator activity","cell-cell adherens junction;cytoskeleton;focal adhesion;transcription factor complex;Z disc",{"$nulls":3},8,8,8,"40.4","40.4","40.4","36.071",0,"71.385",315020000,24,"0.46318",1,"0.672519","1.22848","sp|O00151|PDLI1_HUMAN","sp|O00151|PDLI1_HUMAN",190,"O00151","PDLI1_HUMAN","PDZ and LIM domain protein 1",null,"PDLIM1"]
["22.2214","22.044","21.8642","21.0566",{"$nulls":3},"cellular response to growth factor stimulus;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;muscle contraction;muscle organ development;negative regulation of catenin import into nucleus;negative regulation of fibroblast proliferation;positive regulation of protein export from nucleus;regulation of canonical Wnt signaling pathway;skeletal muscle cell differentiation","actin binding;beta-tubulin binding;cadherin binding","cytoplasm;endoplasmic reticulum;integral component of membrane;membrane;microtubule;nuclear envelope;nuclear inner membrane;nuclear membrane;nuclear outer membrane;nucleoplasm","Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM)",null,null,13,13,13,"64.2","64.2","64.2","28.994",0,"36.921",719150000,67,"0.610057",1,"0.67231","1.62613","sp|P50402|EMD_HUMAN;tr|Q5HY57|Q5HY57_HUMAN;tr|F8WEQ1|F8WEQ1_HUMAN","sp|P50402|EMD_HUMAN;tr|Q5HY57|Q5HY57_HUMAN",1623,"P50402","EMD_HUMAN","Emerin",null,"EMD"]
["21.2501","21.2459","21.693","19.4586",{"$nulls":3},"N-terminal protein amino acid modification;peptidyl-methionine modification;protein processing;regulation of rhodopsin mediated signaling pathway","aminopeptidase activity;metal ion binding;metalloexopeptidase activity;RNA binding","cytoplasm;cytosol;plasma membrane",{"$nulls":3},12,12,12,"33.9","33.9","33.9","52.891",0,"38.726",450630000,28,"0.21574",1,"0.672202","0.601693","sp|P50579|MAP2_HUMAN;tr|F8VQZ7|F8VQZ7_HUMAN;tr|F8VRR3|F8VRR3_HUMAN;tr|G3V1U3|G3V1U3_HUMAN;tr|F8VSC4|F8VSC4_HUMAN;tr|F8VY03|F8VY03_HUMAN;tr|F8VZX9|F8VZX9_HUMAN","sp|P50579|MAP2_HUMAN;tr|F8VQZ7|F8VQZ7_HUMAN;tr|F8VRR3|F8VRR3_HUMAN;tr|G3V1U3|G3V1U3_HUMAN",1631,"P50579","MAP2_HUMAN","Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}","AP 2 {ECO:0000255|HAMAP-Rule:MF_03175};etAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}","METAP2"]
["20.9023","20.9802","21.0122","19.5262",{"$nulls":5},"mitochondrion",{"$nulls":3},8,8,8,"32.4","32.4","32.4","35.29",0,"16.866",290230000,28,"0.335663",1,"0.672101","0.903371","tr|A0A087X2D5|A0A087X2D5_HUMAN;sp|Q9BRJ2|RM45_HUMAN;tr|A0A0G2JMS5|A0A0G2JMS5_HUMAN;tr|A0A087WU62|A0A087WU62_HUMAN","tr|A0A087X2D5|A0A087X2D5_HUMAN;sp|Q9BRJ2|RM45_HUMAN;tr|A0A0G2JMS5|A0A0G2JMS5_HUMAN;tr|A0A087WU62|A0A087WU62_HUMAN",3931,"A0A087X2D5","A0A087X2D5_HUMAN",null,null,"MRPL45"]
["20.6126","19.8999","20.751","18.4217",{"$nulls":3},"attachment of spindle microtubules to kinetochore;cell division;chromosome segregation;mitotic cell cycle;mitotic spindle assembly;protein deubiquitination;protein K63-linked deubiquitination;response to ischemia","microtubule binding;polyubiquitin modification-dependent protein binding","BRISC complex;cytoplasm;cytosol;microtubule;spindle pole",{"$nulls":3},8,8,8,27,27,27,"46.9",0,"25.539",176580000,26,"0.195503",1,"0.669905","0.550024","sp|Q15018|F175B_HUMAN","sp|Q15018|F175B_HUMAN",2424,"Q15018","ABRX2_HUMAN","BRISC complex subunit Abraxas 2 {ECO:0000312|HGNC:HGNC:28975}",null,"ABRAXAS2"]
["17.9424","18.5452","18.3897","16.7582",{"$nulls":9},9,9,9,"16.9","16.9","16.9","87.183",0,"22.605",304420000,18,"0.282613",1,"0.669871","0.770319","tr|A0A0A0MS45|A0A0A0MS45_HUMAN;sp|Q9H9E3|COG4_HUMAN;tr|J3KNI1|J3KNI1_HUMAN;tr|H3BSD2|H3BSD2_HUMAN;tr|H3BMV9|H3BMV9_HUMAN;tr|E9PRT5|E9PRT5_HUMAN;tr|J3KRB5|J3KRB5_HUMAN;tr|J3QLW1|J3QLW1_HUMAN","tr|A0A0A0MS45|A0A0A0MS45_HUMAN;sp|Q9H9E3|COG4_HUMAN;tr|J3KNI1|J3KNI1_HUMAN",4276,"A0A0A0MS45","A0A0A0MS45_HUMAN",null,null,"COG4"]
["21.209","20.9278","21.2579","19.5394",{"$nulls":4},"GTP binding;GTPase activity",{"$nulls":4},13,13,7,32,32,"19.6","52.832",0,"62.244",488040000,40,"0.282169",1,"0.669724","0.769206","tr|H3BR35|H3BR35_HUMAN;sp|P15170|ERF3A_HUMAN;tr|H3BSV8|H3BSV8_HUMAN","tr|H3BR35|H3BR35_HUMAN;sp|P15170|ERF3A_HUMAN",1058,"H3BR35","H3BR35_HUMAN",null,null,"GSPT1"]
["20.5115","19.832","20.8035","18.2017",{"$nulls":3},"GDP-mannose biosynthetic process","GTP binding;mannose-1-phosphate guanylyltransferase activity","cytoplasm;extracellular exosome;mitochondrion","Amino sugar and nucleotide sugar metabolism;Fructose and mannose metabolism;Metabolic pathways",null,null,8,8,8,"26.9","26.9","26.9","39.834",0,"20.302",189820000,17,"0.175201",1,"0.669178","0.497694","sp|Q9Y5P6|GMPPB_HUMAN","sp|Q9Y5P6|GMPPB_HUMAN",5050,"Q9Y5P6","GMPPB_HUMAN","Mannose-1-phosphate guanyltransferase beta",null,"GMPPB"]
["18.6874","18.6739","18.0746","17.9493",{"$nulls":4},"transferase activity, transferring glycosyl groups",{"$nulls":4},3,3,3,"15.6","15.6","15.6","19.264","0.000246","5.9848",82768000,7,"2.05708",1,"0.668675","10.6088","tr|K7EID2|K7EID2_HUMAN;sp|Q9BT22|ALG1_HUMAN","tr|K7EID2|K7EID2_HUMAN;sp|Q9BT22|ALG1_HUMAN",3958,"K7EID2","K7EID2_HUMAN",null,null,"ALG1"]
["21.7224","19.7911","21.9632","18.2145",{"$nulls":4},"RNA binding",{"$nulls":4},6,6,1,"8.4","8.4","1.9","95.696",0,"15.714",7479100000,18,"0.107101",1,"0.66784","0.316738","tr|H0YDK8|H0YDK8_HUMAN;tr|Q5T1Z4|Q5T1Z4_HUMAN;tr|Q5T1Z8|Q5T1Z8_HUMAN;tr|H0YC97|H0YC97_HUMAN","tr|H0YDK8|H0YDK8_HUMAN;tr|Q5T1Z4|Q5T1Z4_HUMAN;tr|Q5T1Z8|Q5T1Z8_HUMAN;tr|H0YC97|H0YC97_HUMAN",5257,"H0YDK8","H0YDK8_HUMAN",null,null,"PUM1"]
["16.6432","18.2721","16.7872","16.7931",{"$nulls":4},"ATP binding",{"$nulls":4},7,7,7,"10.6","10.6","10.6","126.98",0,"20.135",97447000,21,"0.302226",1,"0.667469","0.819494","tr|B5MDQ0|B5MDQ0_HUMAN;sp|Q2NKX8|ERC6L_HUMAN","tr|B5MDQ0|B5MDQ0_HUMAN;sp|Q2NKX8|ERC6L_HUMAN",2596,"B5MDQ0","B5MDQ0_HUMAN",null,null,"ERCC6L"]
["23.2001","24.1495","22.7084","23.3081",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","protein homodimerization activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;nucleus;proteasome complex;proteasome regulatory particle;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,11,11,11,"51.9","51.9","51.9","37.025",0,"102.4",1515900000,67,"0.447219",1,"0.666529","1.18704","sp|P51665|PSMD7_HUMAN;tr|H3BNT7|H3BNT7_HUMAN;tr|H3BTM8|H3BTM8_HUMAN;tr|H3BQV2|H3BQV2_HUMAN","sp|P51665|PSMD7_HUMAN;tr|H3BNT7|H3BNT7_HUMAN;tr|H3BTM8|H3BTM8_HUMAN",1665,"P51665","PSMD7_HUMAN","26S proteasome non-ATPase regulatory subunit 7",null,"PSMD7"]
["19.4462","20.2287","19.02","19.3261",{"$nulls":3},"ATP-dependent chromatin remodeling;cellular response to leukemia inhibitory factor;CENP-A containing nucleosome assembly;chromatin remodeling;chromatin silencing at rDNA;covalent chromatin modification;DNA-templated transcription, initiation;nucleosome assembly;nucleosome positioning;positive regulation of gene expression, epigenetic;positive regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter","ATP binding;ATPase activity;DNA binding;helicase activity;nucleosome binding","chromatin silencing complex;condensed chromosome;fibrillar center;nucleoplasm;nucleus;NURF complex;RSF complex",{"$nulls":3},35,35,35,"38.7","38.7","38.7","121.9",0,"169.79",2603200000,228,"0.594143",1,"0.664393","1.58135","sp|O60264|SMCA5_HUMAN;sp|P28370|SMCA1_HUMAN;tr|A0A0A0MRP6|A0A0A0MRP6_HUMAN;tr|B7ZLQ5|B7ZLQ5_HUMAN","sp|O60264|SMCA5_HUMAN",460,"O60264","SMCA5_HUMAN","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5","WI/SNF-related matrix-associated actin-dependent regulator of chromatin A5","SMARCA5"]
["21.5998","21.5117","21.6284","20.1554",{"$nulls":3},"G2/M transition of mitotic cell cycle;protein demethylation","cadherin binding;protein C-terminal methylesterase activity;protein kinase binding;protein phosphatase 2A binding;protein phosphatase binding;protein phosphatase inhibitor activity;protein phosphatase regulator activity","nucleoplasm",{"$nulls":3},10,10,10,"31.9","31.9","31.9","42.315",0,"56.687",340740000,26,"0.334228",1,"0.663884","0.899767","sp|Q9Y570|PPME1_HUMAN","sp|Q9Y570|PPME1_HUMAN",5031,"Q9Y570","PPME1_HUMAN","Protein phosphatase methylesterase 1","ME-1","PPME1"]
["22.6024","22.6999","22.4829","21.4953",{"$nulls":3},"activation of innate immune response;circadian rhythm;DNA recombination;DNA repair;innate immune response;mRNA processing;mRNA splicing, via spliceosome;negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;negative regulation of transcription, DNA-templated;regulation of circadian rhythm;regulation of transcription, DNA-templated;RNA splicing;transcription, DNA-templated","chromatin binding;core promoter binding;identical protein binding;RNA binding;RNA polymerase II distal enhancer sequence-specific DNA binding;transcription regulatory region sequence-specific DNA binding","membrane;nuclear matrix;nuclear speck;nucleolus;nucleoplasm;nucleus;paraspeckles;RNA polymerase II transcription factor complex",{"$nulls":3},20,20,19,"51.2","51.2","49.5","54.231",0,"122.58",1172800000,110,"0.503444",1,"0.662103","1.33435","sp|Q15233|NONO_HUMAN;tr|H7C367|H7C367_HUMAN;tr|C9JYS8|C9JYS8_HUMAN;tr|C9IZL7|C9IZL7_HUMAN;tr|C9J4X2|C9J4X2_HUMAN","sp|Q15233|NONO_HUMAN",2461,"Q15233","NONO_HUMAN","Non-POU domain-containing octamer-binding protein","onO protein","NONO"]
["19.1126","19.6345","17.8616","19.5622",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;ER to Golgi vesicle-mediated transport;microtubule-based movement;neutrophil degranulation",null,"azurophil granule lumen;cytosol;dynactin complex;extracellular region;ficolin-1-rich granule lumen",{"$nulls":3},4,4,4,"17.3","17.3","17.3","46.306",0,"18.078",90799000,11,"0.272099",1,"0.661687","0.743938","sp|Q9NZ32|ARP10_HUMAN;tr|V9GYX7|V9GYX7_HUMAN;tr|G3V2Q5|G3V2Q5_HUMAN;tr|G3V5Y4|G3V5Y4_HUMAN;tr|F6S9Y6|F6S9Y6_HUMAN;tr|G3V4K6|G3V4K6_HUMAN;tr|G3V524|G3V524_HUMAN","sp|Q9NZ32|ARP10_HUMAN;tr|V9GYX7|V9GYX7_HUMAN;tr|G3V2Q5|G3V2Q5_HUMAN;tr|G3V5Y4|G3V5Y4_HUMAN;tr|F6S9Y6|F6S9Y6_HUMAN",4582,"Q9NZ32","ARP10_HUMAN","Actin-related protein 10",null,"ACTR10"]
["22.3761","22.4281","22.8211","20.6627",{"$nulls":3},"embryonic organ development;global genome nucleotide-excision repair;nucleotide-excision repair;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, preincision complex assembly;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein folding;regulation of proteasomal ubiquitin-dependent protein catabolic process;spermatogenesis","damaged DNA binding;polyubiquitin modification-dependent protein binding;single-stranded DNA binding","cytosol;nucleoplasm;nucleus;proteasome complex;XPC complex","Nucleotide excision repair;Protein processing in endoplasmic reticulum",null,null,7,7,7,"24.4","24.4","24.4","43.171",0,"100.5",736890000,61,"0.219621",1,"0.660197","0.611559","sp|P54727|RD23B_HUMAN;tr|H0Y579|H0Y579_HUMAN;tr|Q5W0S5|Q5W0S5_HUMAN;tr|Q5W0S4|Q5W0S4_HUMAN;tr|K7ENJ0|K7ENJ0_HUMAN;tr|K7ELW1|K7ELW1_HUMAN;sp|P54725|RD23A_HUMAN","sp|P54727|RD23B_HUMAN",1740,"P54727","RD23B_HUMAN","UV excision repair protein RAD23 homolog B","HR23B;R23B","RAD23B"]
["17.6112","17.4036","17.3756","16.3191",{"$nulls":3},"lysosome localization",null,"BORC complex;lysosomal membrane",{"$nulls":3},4,4,4,"16.5","16.5","16.5","37.226","0.00026667","7.72",33012000,8,"0.462244",1,"0.660075","1.22604","sp|Q96GS4|CQ059_HUMAN","sp|Q96GS4|CQ059_HUMAN",3707,"Q96GS4","BORC6_HUMAN","BLOC-1-related complex subunit 6 {ECO:0000305}",null,"BORCS6"]
["23.2782","23.6044","23.2714","22.2967",{"$nulls":3},"cellular glucose homeostasis;cellular response to X-ray;chromatin organization;double-strand break repair via homologous recombination;gene conversion;interstrand cross-link repair;modulation by host of RNA binding by virus;modulation by host of viral RNA-binding transcription factor activity;positive regulation by host of viral genome replication;positive regulation by host of viral transcription;positive regulation of insulin receptor signaling pathway;regulation of DNA replication;regulation of DNA strand elongation;regulation of insulin receptor signaling pathway;regulation of transcription from RNA polymerase II promoter;release from viral latency;replication fork processing","chromatin binding;double-stranded DNA binding;RNA binding;single-stranded DNA binding;transcription factor binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","chromatin;cytoplasm;nuclear chromatin;nucleolus;nucleus",{"$nulls":3},6,6,6,"21.8","21.8","21.8","27.296",0,"145.06",772750000,40,"0.482468",1,"0.657284","1.27894","sp|Q9H1E3|NUCKS_HUMAN","sp|Q9H1E3|NUCKS_HUMAN",4154,"Q9H1E3","NUCKS_HUMAN","Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1",null,"NUCKS1"]
["21.71","21.7031","22.0259","20.0739",{"$nulls":3},"cell redox homeostasis",null,"cell;integral component of membrane",{"$nulls":3},9,9,9,"31.4","31.4","31.4","34.037",0,"36.138",537560000,45,"0.243809",1,"0.656619","0.672765","sp|Q9Y320|TMX2_HUMAN;tr|E9PSF0|E9PSF0_HUMAN;tr|E9PRL5|E9PRL5_HUMAN;tr|H3BSU7|H3BSU7_HUMAN;tr|E9PLR1|E9PLR1_HUMAN;tr|G3V155|G3V155_HUMAN","sp|Q9Y320|TMX2_HUMAN",4959,"Q9Y320","TMX2_HUMAN","Thioredoxin-related transmembrane protein 2",null,"TMX2"]
["22.6138","22.8888","22.6857","21.5048",{"$nulls":9},7,7,7,"53.1","53.1","53.1","21.883",0,"31.749",726710000,67,"0.4064",1,"0.656044","1.08221","tr|C9JQV0|C9JQV0_HUMAN;sp|Q9BRJ6|CG050_HUMAN;tr|H7C0T1|H7C0T1_HUMAN;tr|H7C2R9|H7C2R9_HUMAN","tr|C9JQV0|C9JQV0_HUMAN;sp|Q9BRJ6|CG050_HUMAN;tr|H7C0T1|H7C0T1_HUMAN;tr|H7C2R9|H7C2R9_HUMAN",3932,"C9JQV0","C9JQV0_HUMAN",null,null,"C7orf50"]
["21.2635","21.9932","21.5315","20.414",{"$nulls":3},"autophagosome assembly;Golgi organization;membrane fusion;nuclear envelope reassembly;proteasome-mediated ubiquitin-dependent protein catabolic process","ATPase binding;phospholipid binding;protein phosphatase regulator activity;ubiquitin binding","chromosome;cytosol;Golgi stack;intermediate filament cytoskeleton;nucleoplasm;nucleus;plasma membrane;VCP-NSFL1C complex","Protein processing in endoplasmic reticulum",null,null,7,7,7,30,30,30,"40.572",0,"72.396",520880000,47,"0.367097",1,"0.655641","0.982509","sp|Q9UNZ2|NSF1C_HUMAN;tr|F2Z2K0|F2Z2K0_HUMAN;tr|R4GNE6|R4GNE6_HUMAN","sp|Q9UNZ2|NSF1C_HUMAN;tr|F2Z2K0|F2Z2K0_HUMAN",4858,"Q9UNZ2","NSF1C_HUMAN","NSFL1 cofactor p47",null,"NSFL1C"]
["20.1593","18.0856","19.9462","16.99",{"$nulls":3},"cell redox homeostasis;IRE1-mediated unfolded protein response;oxidation-reduction process;protein folding;response to endoplasmic reticulum stress","oxidoreductase activity;peptide disulfide oxidoreductase activity;protein disulfide isomerase activity","endoplasmic reticulum lumen;endoplasmic reticulum membrane",{"$nulls":3},16,16,16,"40.5","40.5","40.5","59.594",0,"85.375",880390000,93,"0.123923",1,"0.654335","0.362414","sp|Q14554|PDIA5_HUMAN;tr|C9JY10|C9JY10_HUMAN;tr|H7C4F9|H7C4F9_HUMAN","sp|Q14554|PDIA5_HUMAN",2368,"Q14554","PDIA5_HUMAN","Protein disulfide-isomerase A5",null,"PDIA5"]
["17.001","16.7033","17.7972","14.6004",{"$nulls":3},"choline transport;neutrophil degranulation;phosphatidylcholine biosynthetic process;positive regulation of I-kappaB kinase/NF-kappaB signaling;transmembrane transport","choline transmembrane transporter activity;signal transducer activity","extracellular exosome;integral component of membrane;lysosomal membrane;plasma membrane;specific granule membrane","Choline metabolism in cancer",null,null,3,3,3,5,5,5,"80.123","0.0025147","3.2815",31825000,2,"0.140608",1,"0.653387","0.407018","sp|Q8IWA5|CTL2_HUMAN;tr|K7EPV6|K7EPV6_HUMAN;tr|K7ESF5|K7ESF5_HUMAN;tr|K7ER17|K7ER17_HUMAN","sp|Q8IWA5|CTL2_HUMAN;tr|K7EPV6|K7EPV6_HUMAN;tr|K7ESF5|K7ESF5_HUMAN",3123,"Q8IWA5","CTL2_HUMAN","Choline transporter-like protein 2",null,"SLC44A2"]
[1,"20.1078",1,"18.8025",{"$nulls":3},"cellular protein metabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated","RNA binding","nucleoplasm",{"$nulls":3},6,6,6,"29.5","29.5","29.5","28.669",0,"20.797",350300000,21,"0.0156167",1,"0.652649","0.0499812","sp|Q9P031|TAP26_HUMAN;tr|F8VNY5|F8VNY5_HUMAN","sp|Q9P031|TAP26_HUMAN;tr|F8VNY5|F8VNY5_HUMAN",4611,"Q9P031","TAP26_HUMAN","Thyroid transcription factor 1-associated protein 26","TF-1-associated protein 26","CCDC59"]
["17.5711","16.5693","17.5907","15.2479",{"$nulls":3},"activation of GTPase activity;axonogenesis;establishment of neuroblast polarity;interkinetic nuclear migration;microtubule cytoskeleton organization;neuron projection development;positive regulation of peptidyl-serine phosphorylation;positive regulation of vascular associated smooth muscle cell migration;regulation of neurogenesis;small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity;Rac GTPase binding","axon;basal part of cell;focal adhesion;growth cone;intracellular;neuron projection",{"$nulls":3},12,12,11,"7.3","7.3","6.9","242.56",0,"30.72",145590000,26,"0.180309",1,"0.650918","0.510913","sp|Q96N67|DOCK7_HUMAN;tr|A0A0C4DGY6|A0A0C4DGY6_HUMAN;tr|H0Y7L2|H0Y7L2_HUMAN;tr|A2A369|A2A369_HUMAN;sp|Q8NF50|DOCK8_HUMAN","sp|Q96N67|DOCK7_HUMAN",3776,"Q96N67","DOCK7_HUMAN","Dedicator of cytokinesis protein 7",null,"DOCK7"]
["16.6477","17.0184","16.6514","15.7132",{"$nulls":3},"angiogenesis;cardiac epithelial to mesenchymal transition;cell-matrix adhesion;collagen catabolic process;extracellular matrix disassembly;extracellular matrix organization;immune response to tumor cell;innate immune response;integrin-mediated signaling pathway;male gonad development;negative regulation of cell growth;negative regulation of cell migration;negative regulation of cell-matrix adhesion;negative regulation of receptor binding;protein kinase C signaling;tissue regeneration","integrin binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;SH3 domain binding","acrosomal vesicle;adherens junction;cell projection;cell surface;extracellular exosome;integral component of membrane;plasma membrane",{"$nulls":3},2,2,2,"4.1","4.1","4.1","92.958","0.0065515","2.6012",28620000,1,"0.486664",1,"0.650696","1.28998","sp|Q13444|ADA15_HUMAN","sp|Q13444|ADA15_HUMAN",2258,"Q13444","ADA15_HUMAN","Disintegrin and metalloproteinase domain-containing protein 15","DAM 15","ADAM15"]
["17.254","18.2407","17.9509","16.2424",{"$nulls":3},"cytoskeleton organization","actin binding",{"$nulls":4},4,4,4,"14.7","14.7","14.7","46.07","0.00024944","6.3222",43342000,10,"0.238578",1,"0.650669","0.659562","tr|J3QSX6|J3QSX6_HUMAN;tr|F8W8M4|F8W8M4_HUMAN;tr|A0A0A0MRL6|A0A0A0MRL6_HUMAN;sp|O14639|ABLM1_HUMAN;tr|H0Y7N6|H0Y7N6_HUMAN;tr|F6XFR5|F6XFR5_HUMAN","tr|J3QSX6|J3QSX6_HUMAN;tr|F8W8M4|F8W8M4_HUMAN;tr|A0A0A0MRL6|A0A0A0MRL6_HUMAN;sp|O14639|ABLM1_HUMAN",267,"J3QSX6","J3QSX6_HUMAN",null,null,"ABLIM1"]
["16.3688","17.3965","16.6587","15.8053",{"$nulls":3},"defense response to virus;interferon-beta production;protein K63-linked ubiquitination;regulation of type I interferon production;response to type I interferon","RNA binding;ubiquitin-protein transferase activity;zinc ion binding","cytoplasm;cytosol",{"$nulls":3},2,2,2,"3.4","3.4","3.4","81.487",0,"8.5377",38860000,12,"0.363777",1,"0.650652","0.97413","sp|Q9BRZ2|TRI56_HUMAN","sp|Q9BRZ2|TRI56_HUMAN",3944,"Q9BRZ2","TRI56_HUMAN","E3 ubiquitin-protein ligase TRIM56",null,"TRIM56"]
["22.957","23.3768","23.4345","21.6005",{"$nulls":3},"blastocyst development;cell cycle;cell proliferation;DNA replication;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;histone exchange;male gonad development;nucleosome assembly;protein transport;response to testosterone","histone binding;Hsp90 protein binding;protein complex binding","cytoplasm;nuclear chromatin;nucleoplasm;nucleus;protein complex",{"$nulls":3},30,30,30,"63.1","63.1","63.1","85.237",0,"323.31",2881600000,175,"0.250763",1,"0.649361","0.690294","sp|P49321|NASP_HUMAN;tr|Q5T624|Q5T624_HUMAN;tr|E9PRH9|E9PRH9_HUMAN;tr|E9PI86|E9PI86_HUMAN;tr|H0YF33|H0YF33_HUMAN;tr|E9PPR5|E9PPR5_HUMAN;tr|H0YDS9|H0YDS9_HUMAN;tr|E9PPQ8|E9PPQ8_HUMAN;tr|E9PNB5|E9PNB5_HUMAN;tr|E9PQG5|E9PQG5_HUMAN;tr|E9PAU3|E9PAU3_HUMAN;tr|E9PKR5|E9PKR5_HUMAN","sp|P49321|NASP_HUMAN;tr|Q5T624|Q5T624_HUMAN",1564,"P49321","NASP_HUMAN","Nuclear autoantigenic sperm protein","ASP","NASP"]
["19.794","20.0321","20.1911","18.3395",{"$nulls":9},2,2,2,"31.5","31.5","31.5","11.545",0,"10.088",47854000,8,"0.252214",1,"0.647747","0.693948","tr|M0QY17|M0QY17_HUMAN;tr|M0R3F4|M0R3F4_HUMAN;tr|M0R2A4|M0R2A4_HUMAN;tr|M0R2K3|M0R2K3_HUMAN;tr|M0R193|M0R193_HUMAN;tr|M0R0I0|M0R0I0_HUMAN;tr|M0R2I2|M0R2I2_HUMAN;tr|J3KQS6|J3KQS6_HUMAN;sp|Q9NWV8|BABA1_HUMAN","tr|M0QY17|M0QY17_HUMAN;tr|M0R3F4|M0R3F4_HUMAN;tr|M0R2A4|M0R2A4_HUMAN;tr|M0R2K3|M0R2K3_HUMAN;tr|M0R193|M0R193_HUMAN;tr|M0R0I0|M0R0I0_HUMAN;tr|M0R2I2|M0R2I2_HUMAN;tr|J3KQS6|J3KQS6_HUMAN;sp|Q9NWV8|BABA1_HUMAN",4523,"M0QY17","M0QXG9_HUMAN",null,null,"BABAM1"]
["17.8414","17.5974","18.0433","16.1001",{"$nulls":3},"endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of SSU-rRNA;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosomal small subunit biogenesis;rRNA processing","enzyme binding;RNA binding;snoRNA binding","90S preribosome;membrane;mitochondrion;Noc4p-Nop14p complex;nucleolus;nucleoplasm;nucleus;small-subunit processome",{"$nulls":3},23,23,23,"31.4","31.4","31.4","97.667",0,"136.22",1026000000,110,"0.239309",1,"0.647672","0.661408","sp|P78316|NOP14_HUMAN;tr|E9PFK5|E9PFK5_HUMAN","sp|P78316|NOP14_HUMAN;tr|E9PFK5|E9PFK5_HUMAN",1968,"P78316","NOP14_HUMAN","Nucleolar protein 14",null,"NOP14"]
[1,"19.1837",1,"17.892",{"$nulls":3},"sensory perception of sound","ubiquitin protein ligase binding","cytosol",{"$nulls":3},2,2,2,"7.2","7.2","7.2","35.822",0,"17.432",120210000,12,"0.0162724",1,"0.645836","0.0520435","sp|Q8IVM0|CCD50_HUMAN","sp|Q8IVM0|CCD50_HUMAN",3116,"Q8IVM0","CCD50_HUMAN","Coiled-coil domain-containing protein 50",null,"CCDC50"]
["17.9739","16.9193","17.9618","15.64",{"$nulls":5},"cytosol;endosome membrane;Golgi apparatus;perinuclear region of cytoplasm",{"$nulls":3},6,6,6,"10.5","10.5","10.5","101.37",0,"16.231",92383000,24,"0.178557",1,"0.645668","0.506382","sp|Q5JSH3|WDR44_HUMAN;tr|H7BY83|H7BY83_HUMAN","sp|Q5JSH3|WDR44_HUMAN;tr|H7BY83|H7BY83_HUMAN",2697,"Q5JSH3","WDR44_HUMAN","WD repeat-containing protein 44",null,"WDR44"]
["19.6203","20.7278","19.1082","19.9499",{"$nulls":3},"cellular amino acid metabolic process","identical protein binding;L-serine ammonia-lyase activity;L-threonine ammonia-lyase activity;pyridoxal phosphate binding","extracellular exosome;mitochondrion","Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways;Valine, leucine and isoleucine biosynthesis",null,null,3,3,3,"18.2","18.2","18.2","34.674",0,"15.737",100700000,5,"0.345186",1,"0.644938","0.927305","sp|Q96GA7|SDSL_HUMAN;tr|F8VYZ3|F8VYZ3_HUMAN","sp|Q96GA7|SDSL_HUMAN;tr|F8VYZ3|F8VYZ3_HUMAN",3697,"Q96GA7","SDSL_HUMAN","Serine dehydratase-like",null,"SDSL"]
[1,"17.6594",1,"16.3699",{"$nulls":3},"maturation of 5.8S rRNA;maturation of LSU-rRNA","RNA binding","nucleolus;preribosome, large subunit precursor",{"$nulls":3},3,3,3,"14.2","14.2","14.2","30.065",0,"10.987",82321000,8,"0.0178165",1,"0.644736","0.0568889","sp|O95478|NSA2_HUMAN;tr|A0A0A0MQZ6|A0A0A0MQZ6_HUMAN;tr|H0YAI9|H0YAI9_HUMAN","sp|O95478|NSA2_HUMAN;tr|A0A0A0MQZ6|A0A0A0MQZ6_HUMAN",737,"O95478","NSA2_HUMAN","Ribosome biogenesis protein NSA2 homolog",null,"NSA2"]
["17.7535","19.778","18.0791","18.1713",{"$nulls":3},"cell cycle;chromatin assembly;DNA repair;DNA replication;DNA replication-dependent nucleosome assembly;protein complex assembly","chromatin binding;chromo shadow domain binding;identical protein binding;unfolded protein binding","CAF-1 complex;nuclear chromatin;protein complex",{"$nulls":3},20,20,20,"31.9","31.9","31.9","106.92",0,"113.96",1380800000,156,"0.227747",1,"0.640588","0.632169","sp|Q13111|CAF1A_HUMAN;tr|K7EJF1|K7EJF1_HUMAN;tr|K7EPA1|K7EPA1_HUMAN","sp|Q13111|CAF1A_HUMAN",2203,"Q13111","CAF1A_HUMAN","Chromatin assembly factor 1 subunit A","AF-1 subunit A","CHAF1A"]
["19.7562","20.7345","19.3545","19.8572",{"$nulls":3},"apoptotic process;cell cycle;cell division;cellular response to exogenous dsRNA;cellular response to starvation;negative regulation of protein binding;positive regulation of autophagosome assembly;positive regulation of protein binding;positive regulation of protein phosphorylation;positive regulation of protein serine/threonine kinase activity;Ras protein signal transduction;regulation of exocyst assembly;regulation of exocyst localization;signal transduction","ATPase binding;GDP binding;GTP binding;GTPase activity;ubiquitin protein ligase binding","extracellular exosome;intracellular;midbody;plasma membrane","Colorectal cancer;Pancreatic cancer;Pathways in cancer;Phospholipase D signaling pathway;Rap1 signaling pathway;Ras signaling pathway",null,null,9,4,4,"46.6","15.5","15.5","23.408",0,"9.9457",84166000,14,"0.437857",1,"0.639478","1.16286","sp|P11234|RALB_HUMAN;tr|C9J6B1|C9J6B1_HUMAN;tr|C9JQB3|C9JQB3_HUMAN","sp|P11234|RALB_HUMAN;tr|C9J6B1|C9J6B1_HUMAN;tr|C9JQB3|C9JQB3_HUMAN",991,"P11234","RALB_HUMAN","Ras-related protein Ral-B",null,"RALB"]
["21.0534","22.8797","21.9573","20.6969",{"$nulls":3},"[2Fe-2S] cluster assembly;interleukin-12-mediated signaling pathway;protein maturation by iron-sulfur cluster transfer",null,"cytoplasm;cytosol;extracellular exosome;nucleus",{"$nulls":3},4,4,4,"61.6","61.6","61.6","10.116",0,"40.201",163700000,21,"0.2058",1,"0.639453","0.576369","sp|Q9H3K6|BOLA2_HUMAN;tr|H3BV85|H3BV85_HUMAN;tr|H3BTW0|H3BTW0_HUMAN;tr|A0A0B4J295|A0A0B4J295_HUMAN;tr|H3BVE0|H3BVE0_HUMAN","sp|Q9H3K6|BOLA2_HUMAN",4188,"Q9H3K6","BOLA2_HUMAN","BolA-like protein 2",null,"BOLA2;BOLA2B"]
["19.68","20.2754","19.6263","19.0541",{"$nulls":3},"activation of MAPK activity;follicle-stimulating hormone signaling pathway;G-protein coupled receptor internalization;G-protein coupled receptor signaling pathway;membrane organization;negative regulation of ERK1 and ERK2 cascade;negative regulation of GTPase activity;negative regulation of interleukin-6 production;negative regulation of interleukin-8 production;negative regulation of NF-kappaB transcription factor activity;negative regulation of Notch signaling pathway;negative regulation of protein ubiquitination;phototransduction;platelet activation;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of ERK1 and ERK2 cascade;positive regulation of histone acetylation;positive regulation of histone H4 acetylation;positive regulation of insulin secretion involved in cellular response to glucose stimulus;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein binding;positive regulation of protein phosphorylation;positive regulation of protein ubiquitination;positive regulation of receptor internalization;positive regulation of Rho protein signal transduction;positive regulation of smooth muscle cell apoptotic process;positive regulation of transcription from RNA polymerase II promoter;proteasome-mediated ubiquitin-dependent protein catabolic process;protein transport;protein ubiquitination;response to drug;stress fiber assembly;transcription from RNA polymerase II promoter;ubiquitin-dependent protein catabolic process","alpha-1A adrenergic receptor binding;alpha-1B adrenergic receptor binding;angiotensin receptor binding;AP-2 adaptor complex binding;arrestin family protein binding;clathrin adaptor activity;cysteine-type endopeptidase inhibitor activity involved in apoptotic process;enzyme inhibitor activity;estrogen receptor binding;follicle-stimulating hormone receptor binding;GTPase activator activity;insulin-like growth factor receptor binding;ion channel binding;mitogen-activated protein kinase kinase binding;protein phosphorylated amino acid binding;transcription factor binding;transcription regulatory region DNA binding;ubiquitin protein ligase binding;V2 vasopressin receptor binding","basolateral plasma membrane;chromatin;clathrin-coated pit;cytoplasm;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;dendritic spine;Golgi membrane;lysosomal membrane;nuclear body;nucleoplasm;nucleus;plasma membrane;postsynaptic density;postsynaptic membrane;pseudopodium","Chemokine signaling pathway;Endocytosis;Hedgehog signaling pathway;MAPK signaling pathway;Morphine addiction;Olfactory transduction;Parathyroid hormone synthesis, secretion and action;Relaxin signaling pathway",null,null,6,5,5,"19.9","18.2","18.2","47.065",0,"19.001",366030000,36,"0.580799",1,"0.637508","1.54417","sp|P49407|ARRB1_HUMAN;tr|E9PM35|E9PM35_HUMAN;tr|H0YET9|H0YET9_HUMAN","sp|P49407|ARRB1_HUMAN;tr|E9PM35|E9PM35_HUMAN",1571,"P49407","ARRB1_HUMAN","Beta-arrestin-1",null,"ARRB1"]
[1,"16.65","15.3768",1,{"$nulls":3},"immune response;multicellular organism growth;negative regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","histone deacetylase binding;metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","nucleus",{"$nulls":3},2,2,2,"4.9","4.9","4.9","64.899","0.00026055","7.2304",53209000,14,"0.0187834",1,"0.636636","0.0599152","sp|Q02086|SP2_HUMAN","sp|Q02086|SP2_HUMAN",2061,"Q02086","SP2_HUMAN","Transcription factor Sp2",null,"SP2"]
["16.4883","18.5474","16.4912","17.2724",{"$nulls":4},"aminopeptidase activity;manganese ion binding;metalloexopeptidase activity","cytoplasm;nucleus",{"$nulls":3},3,3,3,9,9,9,"55.86","0.0013132","3.8576",52995000,5,"0.206298",1,"0.636059","0.577639","sp|Q8NDH3|PEPL1_HUMAN;tr|H0YEP3|H0YEP3_HUMAN","sp|Q8NDH3|PEPL1_HUMAN",3316,"Q8NDH3","PEPL1_HUMAN","Probable aminopeptidase NPEPL1",null,"NPEPL1"]
["18.251","18.8033","18.2003","17.5827",{"$nulls":3},"oocyte development;regulation of transcription, DNA-templated;spermatogenesis;transcription from RNA polymerase II promoter;translational attenuation","DNA binding;RNA binding","cytoplasm;fibrillar center;nucleus",{"$nulls":3},5,2,2,"19.2","9.3","9.3","38.517","0.00026261","7.4155",45389000,9,"0.577309",1,"0.635692","1.53449","sp|Q9Y2T7|YBOX2_HUMAN","sp|Q9Y2T7|YBOX2_HUMAN",4939,"Q9Y2T7","YBOX2_HUMAN","Y-box-binding protein 2",null,"YBX2"]
["14.7803","18.9039","15.786","16.6276",{"$nulls":3},"activation of GTPase activity;intracellular protein transport;regulation of vesicle fusion","calcium ion binding;GTPase activator activity;Rab GTPase binding","endomembrane system;integral component of membrane;intracellular",{"$nulls":3},7,7,7,"8.6","8.6","8.6","140.52",0,"9.1991",76701000,10,"0.101708",1,"0.635337","0.301928","sp|Q66K14|TBC9B_HUMAN;tr|E5RIN2|E5RIN2_HUMAN;tr|H0YB08|H0YB08_HUMAN;tr|G3V133|G3V133_HUMAN","sp|Q66K14|TBC9B_HUMAN",2784,"Q66K14","TBC9B_HUMAN","TBC1 domain family member 9B",null,"TBC1D9B"]
["20.9953","21.6077","21.285","20.0493",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of peptide antigen via MHC class I;immune response;interferon-gamma-mediated signaling pathway;regulation of immune response;type I interferon signaling pathway;viral process","beta-2-microglobulin binding;peptide antigen binding;TAP binding","cell surface;early endosome membrane;endoplasmic reticulum;ER to Golgi transport vesicle membrane;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of lumenal side of endoplasmic reticulum membrane;integral component of plasma membrane;MHC class I protein complex;phagocytic vesicle membrane;plasma membrane;recycling endosome membrane",{"$nulls":3},7,5,2,"28.5","21.1","7.9","40.904",0,"33.307",466560000,38,"0.342243",1,"0.634356","0.919907","sp|P16188|1A30_HUMAN;tr|Q5SRN7|Q5SRN7_HUMAN;sp|P30447|1A23_HUMAN;sp|P30457|1A66_HUMAN;sp|P30453|1A34_HUMAN;sp|P13746|1A11_HUMAN;sp|P04439|1A03_HUMAN;tr|Q5SRN5|Q5SRN5_HUMAN;tr|Q9GJ45|Q9GJ45_HUMAN;sp|P01891|1A68_HUMAN;tr|B0UXQ0|B0UXQ0_HUMAN;sp|P30512|1A29_HUMAN;sp|P30459|1A74_HUMAN;sp|P30456|1A43_HUMAN;sp|P30450|1A26_HUMAN;sp|P18462|1A25_HUMAN;sp|P16190|1A33_HUMAN;sp|P16189|1A31_HUMAN;sp|P10314|1A32_HUMAN;tr|A0A0G2JPD3|A0A0G2JPD3_HUMAN","sp|P16188|1A30_HUMAN;tr|Q5SRN7|Q5SRN7_HUMAN;sp|P30447|1A23_HUMAN;sp|P30457|1A66_HUMAN;sp|P30453|1A34_HUMAN;sp|P13746|1A11_HUMAN;sp|P04439|1A03_HUMAN;tr|Q5SRN5|Q5SRN5_HUMAN",1074,"P16188","1A30_HUMAN","HLA class I histocompatibility antigen, A-30 alpha chain",null,"HLA-A"]
["20.0759","20.8244","19.8544","19.7779",{"$nulls":9},12,12,11,"22.8","22.8","21.7","99.813",0,"51.124",325900000,37,"0.63082",1,"0.634003","1.68526","tr|A0A0C4DFT3|A0A0C4DFT3_HUMAN;sp|Q12959|DLG1_HUMAN;tr|E7EQD7|E7EQD7_HUMAN;tr|B4E2H8|B4E2H8_HUMAN;tr|C9IYP1|C9IYP1_HUMAN;tr|C9JUA9|C9JUA9_HUMAN;tr|C9JN61|C9JN61_HUMAN;tr|C9JCP6|C9JCP6_HUMAN;tr|A8MUT6|A8MUT6_HUMAN;tr|H7C166|H7C166_HUMAN;tr|C9J110|C9J110_HUMAN;tr|F2Z2L0|F2Z2L0_HUMAN;tr|H7C325|H7C325_HUMAN;tr|F8W750|F8W750_HUMAN;tr|B5MCC5|B5MCC5_HUMAN;tr|B7Z264|B7Z264_HUMAN;tr|E9PIW2|E9PIW2_HUMAN;tr|B7Z2T4|B7Z2T4_HUMAN;tr|E9PN83|E9PN83_HUMAN;sp|Q15700|DLG2_HUMAN","tr|A0A0C4DFT3|A0A0C4DFT3_HUMAN;sp|Q12959|DLG1_HUMAN;tr|E7EQD7|E7EQD7_HUMAN",2184,"A0A0C4DFT3","A0A0C4DFT3_HUMAN",null,null,"DLG1"]
["15.089","14.3395","15.5848","12.5764",{"$nulls":3},"cell division;cellular response to DNA damage stimulus;female meiosis II;G2/M transition of mitotic cell cycle;intracellular signal transduction;mitotic cell cycle;negative regulation of phosphoprotein phosphatase activity;peptidyl-serine phosphorylation;positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle;regulation of cell cycle","ATP binding;kinase activity;protein phosphatase 2A binding;protein serine/threonine kinase activity","centrosome;cleavage furrow;cytoplasm;nucleoplasm;nucleus",{"$nulls":3},2,1,1,"2.4","1.5","1.5","97.318","0.0037045","3.0117",11156000,4,"0.141267",1,"0.633667","0.408765","sp|Q96GX5|GWL_HUMAN;tr|A0A087WUU7|A0A087WUU7_HUMAN","sp|Q96GX5|GWL_HUMAN;tr|A0A087WUU7|A0A087WUU7_HUMAN",3709,"Q96GX5","GWL_HUMAN","Serine/threonine-protein kinase greatwall","GWL;W;WL","MASTL"]
["19.1051","18.8939","19.7596","16.9741",{"$nulls":3},"mRNA splicing, via spliceosome;transcription-coupled nucleotide-excision repair","RNA binding","catalytic step 2 spliceosome;membrane;nucleoplasm","Spliceosome",null,null,7,7,7,"8.7","8.7","8.7","171.29",0,"17.908",269040000,26,"0.158018",1,"0.632625","0.452924","sp|O60306|AQR_HUMAN","sp|O60306|AQR_HUMAN",462,"O60306","AQR_HUMAN","Intron-binding protein aquarius",null,"AQR"]
["15.8292","16.9951","16.3645","15.1948",{"$nulls":3},"axon guidance;kidney development;Roundabout signaling pathway",null,"axolemma;integral component of membrane",{"$nulls":3},26,26,24,"33.6","33.6","31.3","117.91",0,"71.632",497810000,55,"0.280878",1,"0.632515","0.765968","tr|R4GMM8|R4GMM8_HUMAN;sp|Q9HCK4|ROBO2_HUMAN;tr|F8W703|F8W703_HUMAN;tr|A0A087WWM5|A0A087WWM5_HUMAN;tr|F8WBR3|F8WBR3_HUMAN;tr|H7C4V8|H7C4V8_HUMAN;tr|H7C4U9|H7C4U9_HUMAN","tr|R4GMM8|R4GMM8_HUMAN;sp|Q9HCK4|ROBO2_HUMAN;tr|F8W703|F8W703_HUMAN;tr|A0A087WWM5|A0A087WWM5_HUMAN;tr|F8WBR3|F8WBR3_HUMAN",4329,"R4GMM8","R4GMM8_HUMAN",null,null,"ROBO2"]
["22.1189","22.1236","22.5311","20.4469",{"$nulls":3},"intracellular signal transduction;regulation of mRNA stability;regulation of transcription, DNA-templated","DNA binding;mRNA 3'-UTR binding;phosphatase binding","cytoplasm;cytoplasmic exosome (RNase complex);cytosol;extracellular exosome;P granule;P-body",{"$nulls":3},3,3,3,"51.7","51.7","51.7","15.892",0,"22.123",212220000,24,"0.217705",1,"0.632249","0.606691","sp|Q9Y2V2|CHSP1_HUMAN;tr|H3BSW7|H3BSW7_HUMAN;tr|H3BUY4|H3BUY4_HUMAN;tr|H3BPY5|H3BPY5_HUMAN;tr|H3BNU9|H3BNU9_HUMAN;tr|H3BTK3|H3BTK3_HUMAN;tr|I3L3X8|I3L3X8_HUMAN","sp|Q9Y2V2|CHSP1_HUMAN;tr|H3BSW7|H3BSW7_HUMAN;tr|H3BUY4|H3BUY4_HUMAN;tr|H3BPY5|H3BPY5_HUMAN;tr|H3BNU9|H3BNU9_HUMAN",4942,"Q9Y2V2","CHSP1_HUMAN","Calcium-regulated heat-stable protein 1",null,"CARHSP1"]
["20.9936","21.2522","21.1921","19.79",{"$nulls":3},"blood coagulation;negative regulation of G0 to G1 transition;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;viral process","chromatin binding;histone deacetylase binding;identical protein binding;macromolecular complex binding;methylated histone binding;protein binding, bridging;protein homodimerization activity;repressing transcription factor binding;ribonucleoprotein complex binding","chromocenter;histone deacetylase complex;histone methyltransferase complex;kinetochore;macromolecular complex;nuclear chromosome, telomeric region;nuclear envelope;nuclear heterochromatin;nuclear pericentric heterochromatin;nucleolus;nucleoplasm;nucleus;pericentric heterochromatin;ribonucleoprotein complex;transcriptional repressor complex",{"$nulls":3},5,5,5,"30.4","30.4","30.4","22.225",0,"11.579",154330000,16,"0.328837",1,"0.631778","0.886233","sp|P45973|CBX5_HUMAN;tr|F8VNY3|F8VNY3_HUMAN","sp|P45973|CBX5_HUMAN",1498,"P45973","CBX5_HUMAN","Chromobox protein homolog 5",null,"CBX5"]
["18.0311",1,"16.7684",1,{"$nulls":3},"negative regulation of ion transmembrane transport;negative regulation of protein homooligomerization;positive regulation of protein homodimerization activity;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination","metal ion binding","Cul4A-RING E3 ubiquitin ligase complex;cytoplasm;membrane;nucleolus;nucleus",{"$nulls":3},3,3,3,"16.1","16.1","16.1","50.545","0.0038926","2.946",24692000,6,"0.0170246",1,"0.631377","0.0544058","sp|Q96SW2|CRBN_HUMAN;tr|J3QT87|J3QT87_HUMAN","sp|Q96SW2|CRBN_HUMAN;tr|J3QT87|J3QT87_HUMAN",3826,"Q96SW2","CRBN_HUMAN","Protein cereblon",null,"CRBN"]
["18.7694","20.0501","18.5351","19.0224",{"$nulls":9},31,31,0,"15.5","15.5",0,"286.97",0,"103.41",811610000,78,"0.342653",1,"0.630962","0.920936","tr|E9PEM5|E9PEM5_HUMAN","tr|E9PEM5|E9PEM5_HUMAN",5210,"E9PEM5","E9PEM5_HUMAN",null,null,"LRBA"]
["19.0361","19.1368","19.3045","17.6068",{"$nulls":9},4,4,4,"13.6","13.6","13.6","49.967",0,"20.102",81364000,10,"0.271237",1,"0.630793","0.741773","sp|Q49AR2|CE022_HUMAN","sp|Q49AR2|CE022_HUMAN",2627,"Q49AR2","CE022_HUMAN","UPF0489 protein C5orf22",null,"C5orf22"]
["20.3576","21.2512","20.6521","19.6951",{"$nulls":3},"androgen metabolic process;estrogen biosynthetic process;fatty acid biosynthetic process;fatty-acyl-CoA biosynthetic process;oxidation-reduction process;protein heterotetramerization","3-hydroxyacyl-CoA dehydrogenase activity;3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity;estradiol 17-beta-dehydrogenase activity;NADH binding;testosterone dehydrogenase (NAD+) activity","mitochondrial envelope;mitochondrial matrix;plasma membrane","Fatty acid biosynthesis;Fatty acid metabolism;Metabolic pathways;Steroid hormone biosynthesis",null,null,4,4,4,"21.1","21.1","21.1","26.973",0,"12.784",126980000,12,"0.359552",1,"0.630763","0.963476","sp|Q92506|DHB8_HUMAN","sp|Q92506|DHB8_HUMAN",3482,"Q92506","DHB8_HUMAN","Estradiol 17-beta-dehydrogenase 8",null,"HSD17B8"]
["20.0531","20.5092","20.1474","19.1538",{"$nulls":3},"L-methionine salvage from methylthioadenosine","identical protein binding;S-methyl-5-thioribose-1-phosphate isomerase activity","cell projection;cytosol;fibrillar center;nucleoplasm","Cysteine and methionine metabolism;Metabolic pathways",null,null,6,6,6,"28.2","28.2","28.2","39.149",0,"20.444",186730000,20,"0.434207",1,"0.630527","1.15346","sp|Q9BV20|MTNA_HUMAN","sp|Q9BV20|MTNA_HUMAN",3996,"Q9BV20","MTNA_HUMAN","Methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119}","1Pi {ECO:0000255|HAMAP-Rule:MF_03119};TR-1-P isomerase {ECO:0000255|HAMAP-Rule:MF_03119}","MRI1"]
["22.0867","21.2666","22.3315","19.7615",{"$nulls":3},"maintenance of gastrointestinal epithelium;O-glycan processing;stimulatory C-type lectin receptor signaling pathway","protein homodimerization activity","apical plasma membrane;cytosol;extracellular exosome;extracellular space;Golgi lumen;integral component of membrane;plasma membrane",{"$nulls":3},7,7,7,"20.7","20.7","20.7","54.603",0,"27.021",416450000,30,"0.16348",1,"0.630192","0.467207","sp|Q9H3R2|MUC13_HUMAN;tr|C9IZG1|C9IZG1_HUMAN","sp|Q9H3R2|MUC13_HUMAN",4194,"Q9H3R2","MUC13_HUMAN","Mucin-13","UC-13","MUC13"]
["18.6939","18.3559","18.7821","17.0117",{"$nulls":3},"DNA repair;DNA strand renaturation;double-strand break repair via homologous recombination","annealing helicase activity;ATP binding;ATP-dependent 3'-5' DNA helicase activity;ATP-dependent DNA helicase activity;DNA binding;DNA helicase activity;four-way junction helicase activity","chromosome;cytoplasm;membrane;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"8.6","8.6","8.6","73.457",0,"10.371",88953000,15,"0.253368",1,"0.62799","0.696853","sp|P46063|RECQ1_HUMAN;tr|F5H4P4|F5H4P4_HUMAN;tr|F5H3W0|F5H3W0_HUMAN;tr|F5H2L2|F5H2L2_HUMAN;tr|F8WA66|F8WA66_HUMAN;tr|F8WD97|F8WD97_HUMAN","sp|P46063|RECQ1_HUMAN",1503,"P46063","RECQ1_HUMAN","ATP-dependent DNA helicase Q1",null,"RECQL"]
["24.6856","26.1588","24.7681","24.8203",{"$nulls":3},"cellular response to gamma radiation;cellular response to UV;cytoplasmic translation;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;positive regulation of translation;regulation of translation involved in cellular response to UV;ribosomal large subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA 5'-UTR binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;cytosolic ribosome;extracellular exosome;membrane;nucleolus;nucleoplasm;ribonucleoprotein complex","Ribosome",null,null,12,12,2,"53.8","53.8","11.7","17.258",0,"106.5",29820000000,589,"0.3152",1,"0.627979","0.85202","sp|P61254|RL26_HUMAN;tr|J3QRI7|J3QRI7_HUMAN;tr|J3QQQ9|J3QQQ9_HUMAN;tr|J3QQV1|J3QQV1_HUMAN;tr|J3QRC4|J3QRC4_HUMAN;tr|J3KTJ8|J3KTJ8_HUMAN;tr|E5RIT6|E5RIT6_HUMAN;tr|J3KS10|J3KS10_HUMAN;tr|J3KSS0|J3KSS0_HUMAN;tr|E5RHH1|E5RHH1_HUMAN","sp|P61254|RL26_HUMAN;tr|J3QRI7|J3QRI7_HUMAN;tr|J3QQQ9|J3QQQ9_HUMAN;tr|J3QQV1|J3QQV1_HUMAN;tr|J3QRC4|J3QRC4_HUMAN;tr|J3KTJ8|J3KTJ8_HUMAN;tr|E5RIT6|E5RIT6_HUMAN",1841,"P61254","RL26_HUMAN","60S ribosomal protein L26",null,"RPL26"]
["18.1329","19.9302","18.2052","18.6035",{"$nulls":3},"attachment of mitotic spindle microtubules to kinetochore;cell division;mitotic cell cycle checkpoint;mitotic spindle assembly checkpoint;negative regulation of T cell proliferation;regulation of metaphase plate congression;sister chromatid cohesion;thymus development","identical protein binding;kinetochore binding","actin cytoskeleton;centrosome;condensed chromosome kinetochore;cytosol;kinetochore;mitotic spindle;nuclear envelope;nucleus;spindle;spindle pole","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Viral carcinogenesis",null,null,11,11,11,"19.2","19.2","19.2","83.066",0,"28.942",165530000,31,"0.247223",1,"0.627201","0.681372","sp|Q9Y6D9|MD1L1_HUMAN;tr|C9JTA2|C9JTA2_HUMAN;tr|C9JPS1|C9JPS1_HUMAN;tr|C9K086|C9K086_HUMAN;tr|C9JIR0|C9JIR0_HUMAN;tr|C9JP81|C9JP81_HUMAN;tr|C9J9H5|C9J9H5_HUMAN;tr|C9JX80|C9JX80_HUMAN","sp|Q9Y6D9|MD1L1_HUMAN",5090,"Q9Y6D9","MD1L1_HUMAN","Mitotic spindle assembly checkpoint protein MAD1",null,"MAD1L1"]
["20.6412","21.2965","19.738","20.9454",{"$nulls":3},"mitotic chromosome condensation;vacuolar transport;vesicle-mediated transport",null,"ESCRT III complex;nuclear matrix",{"$nulls":3},4,4,4,"18.2","18.2","18.2","19.531","0.00025641","6.937",160820000,13,"0.339545",1,"0.627189","0.913124","tr|F8VUA2|F8VUA2_HUMAN;sp|Q9HD42|CHM1A_HUMAN;tr|F8VVT7|F8VVT7_HUMAN;tr|F5H875|F5H875_HUMAN","tr|F8VUA2|F8VUA2_HUMAN;sp|Q9HD42|CHM1A_HUMAN;tr|F8VVT7|F8VVT7_HUMAN;tr|F5H875|F5H875_HUMAN",4343,"F8VUA2","F8VUA2_HUMAN",null,null,"CHMP1A"]
["15.9897","17.1776","16.5351","15.3791",{"$nulls":3},"defense response to Gram-positive bacterium;defense response to virus;dendritic cell proliferation;I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;negative regulation of gene expression;negative regulation of type I interferon production;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-beta biosynthetic process;positive regulation of interferon-beta production;positive regulation of macroautophagy;positive regulation of peptidyl-serine phosphorylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;positive regulation of xenophagy;protein phosphorylation;regulation of neuron death;regulation of type I interferon production;response to virus;TRIF-dependent toll-like receptor signaling pathway;type I interferon production;viral process","ATP binding;identical protein binding;nucleic acid binding;phosphoprotein binding;protein kinase activity;protein serine/threonine kinase activity","cytoplasm;cytosol;endosome membrane","Cytosolic DNA-sensing pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;IL-17 signaling pathway;Influenza A;Kaposi sarcoma-associated herpesvirus infection;Measles;Mitophagy - animal;NOD-like receptor signaling pathway;Ras signaling pathway;RIG-I-like receptor signaling pathway;Toll-like receptor signaling pathway;Yersinia infection",null,null,4,4,4,"7.8","7.8","7.8","83.641",0,"9.0366",40773000,10,"0.276892",1,"0.626522","0.755967","sp|Q9UHD2|TBK1_HUMAN","sp|Q9UHD2|TBK1_HUMAN",4722,"Q9UHD2","TBK1_HUMAN","Serine/threonine-protein kinase TBK1",null,"TBK1"]
["18.7171","19.374","18.92","17.9189",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;basement membrane organization;cell migration involved in gastrulation;cell-cell adhesion involved in gastrulation;G-protein coupled receptor signaling pathway;in utero embryonic development;vasculature development;visual learning","G-protein alpha-subunit binding;GTPase activator activity;guanyl-nucleotide exchange factor activity","cytoplasm;plasma membrane",{"$nulls":3},5,5,5,"9.4","9.4","9.4","59.709",0,"13.045",116100000,11,"0.392066",1,"0.626105","1.04573","sp|Q9NPQ8|RIC8A_HUMAN;tr|H0YEN0|H0YEN0_HUMAN;tr|H0YE35|H0YE35_HUMAN;tr|E9PSI0|E9PSI0_HUMAN;sp|Q9NVN3|RIC8B_HUMAN;tr|B7WPL0|B7WPL0_HUMAN","sp|Q9NPQ8|RIC8A_HUMAN",4375,"Q9NPQ8","RIC8A_HUMAN","Synembryn-A",null,"RIC8A"]
["19.3605","20.1597","19.2619","19.0096",{"$nulls":3},"cell cycle;cell proliferation;extrinsic apoptotic signaling pathway in absence of ligand;insulin receptor signaling pathway;regulation of glucose import;regulation of protein localization to plasma membrane;signal transduction","identical protein binding;protein kinase B binding","cytoplasm;cytosol;early endosome;early endosome membrane;endosome membrane;extracellular exosome;nucleus;vesicle membrane","Colorectal cancer;Longevity regulating pathway;Pathways in cancer",null,null,11,11,11,"25.2","25.2","25.2","79.663",0,"44.684",235240000,34,"0.561225",1,"0.624384","1.49018","sp|Q9UKG1|DP13A_HUMAN;tr|C9K0C4|C9K0C4_HUMAN;tr|C9JAB0|C9JAB0_HUMAN","sp|Q9UKG1|DP13A_HUMAN",4782,"Q9UKG1","DP13A_HUMAN","DCC-interacting protein 13-alpha","ip13-alpha","APPL1"]
["17.3174","19.4001","17.8596","17.6095",{"$nulls":3},"miRNA metabolic process;positive regulation of RNA interference;pre-miRNA export from nucleus;protein export from nucleus;regulation of protein export from nucleus","mRNA binding;nuclear export signal receptor activity;pre-miRNA binding;pre-miRNA transporter activity;Ran GTPase binding;RNA binding;tRNA binding","cytoplasm;cytosol;micro-ribonucleoprotein complex;nuclear RNA export factor complex;nucleoplasm;nucleus;RNA nuclear export complex","RNA transport",null,null,6,6,6,7,7,7,"136.31",0,"11.686",122870000,6,"0.213182",1,"0.624251","0.595185","sp|Q9HAV4|XPO5_HUMAN;tr|H0Y3W3|H0Y3W3_HUMAN","sp|Q9HAV4|XPO5_HUMAN",4296,"Q9HAV4","XPO5_HUMAN","Exportin-5","xp5","XPO5"]
["19.3962","18.9914","19.3519","17.7911",{"$nulls":3},"apoptotic process;apoptotic signaling pathway;regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding","centrosome;cytosol;intracellular membrane-bounded organelle;nuclear chromatin;nucleoplasm",{"$nulls":3},10,10,10,32,32,32,"44.155",0,"106.22",749310000,68,"0.283199",1,"0.622245","0.771792","sp|Q92785|REQU_HUMAN;tr|J3KMZ8|J3KMZ8_HUMAN;tr|E9PN04|E9PN04_HUMAN","sp|Q92785|REQU_HUMAN;tr|J3KMZ8|J3KMZ8_HUMAN",3529,"Q92785","REQU_HUMAN","Zinc finger protein ubi-d4",null,"DPF2"]
["20.0915","20.4015","18.8472","20.4032",{"$nulls":3},"intracellular protein transport","protein kinase activator activity","intracellular",{"$nulls":3},6,6,6,"32.5","32.5","32.5","36.215",0,"13.968",124380000,17,"0.287714",1,"0.621256","0.783114","tr|I3NI44|I3NI44_HUMAN;tr|J3KQU4|J3KQU4_HUMAN;tr|I3L4I4|I3L4I4_HUMAN;sp|O75674|TM1L1_HUMAN;tr|I3L3T4|I3L3T4_HUMAN;tr|I3L367|I3L367_HUMAN;tr|I3L1G1|I3L1G1_HUMAN;tr|I3L1Q1|I3L1Q1_HUMAN;tr|I3L4N3|I3L4N3_HUMAN;tr|I3L4G0|I3L4G0_HUMAN","tr|I3NI44|I3NI44_HUMAN;tr|J3KQU4|J3KQU4_HUMAN;tr|I3L4I4|I3L4I4_HUMAN;sp|O75674|TM1L1_HUMAN;tr|I3L3T4|I3L3T4_HUMAN;tr|I3L367|I3L367_HUMAN;tr|I3L1G1|I3L1G1_HUMAN",599,"I3NI44","I3NI44_HUMAN",null,null,"TOM1L1"]
["20.5435","20.7756","19.5224","20.555",{"$nulls":4},"translation release factor activity",{"$nulls":4},5,5,5,"32.3","32.3","32.3","21.905",0,"13.243",124330000,11,"0.441887",1,"0.620829","1.17326","tr|J3KS15|J3KS15_HUMAN;sp|Q14197|ICT1_HUMAN;tr|J3QRF8|J3QRF8_HUMAN","tr|J3KS15|J3KS15_HUMAN;sp|Q14197|ICT1_HUMAN",2345,"J3KS15","J3KS15_HUMAN",null,null,"MRPL58"]
["22.8683","23.284","22.7374","22.1751",{"$nulls":3},"proteolysis",null,"proteasome regulatory particle",{"$nulls":3},13,13,13,"44.9","44.9","44.9","32.551",0,"97.949",1017400000,59,"0.661013",1,"0.619866","1.7728","tr|R4GMR5|R4GMR5_HUMAN;sp|P48556|PSMD8_HUMAN;tr|K7EJR3|K7EJR3_HUMAN;tr|K7EJC1|K7EJC1_HUMAN;tr|K7ERW6|K7ERW6_HUMAN;tr|K7ENY6|K7ENY6_HUMAN","tr|R4GMR5|R4GMR5_HUMAN;sp|P48556|PSMD8_HUMAN;tr|K7EJR3|K7EJR3_HUMAN",1545,"R4GMR5","R4GMR5_HUMAN",null,null,"PSMD8"]
["21.4735","21.2221","21.6604","19.7956",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","rRNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit","Ribosome",null,null,9,9,9,"35.9","35.9","35.9","28.449",0,"44.504",1435600000,124,"0.238278",1,"0.619825","0.658803","sp|Q9NX20|RM16_HUMAN;tr|E9PI14|E9PI14_HUMAN","sp|Q9NX20|RM16_HUMAN",4530,"Q9NX20","RM16_HUMAN","39S ribosomal protein L16, mitochondrial","16mt;RP-L16","MRPL16"]
["19.2733","18.963","18.5944","18.4054",{"$nulls":3},"maturation of LSU-rRNA;positive regulation of cell proliferation;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;ribosomal large subunit assembly;rRNA base methylation","RNA binding;rRNA (cytosine-C5-)-methyltransferase activity","nucleolus;nucleoplasm",{"$nulls":3},10,10,10,"18.2","18.2","18.2","89.301",0,"37.187",348400000,70,"1.11613",1,"0.618205","3.40375","sp|P46087|NOP2_HUMAN;tr|A0A087WV73|A0A087WV73_HUMAN;tr|F5GWB7|F5GWB7_HUMAN;tr|F5H709|F5H709_HUMAN;tr|F5H359|F5H359_HUMAN;tr|F5H5X6|F5H5X6_HUMAN;tr|F5H8G6|F5H8G6_HUMAN","sp|P46087|NOP2_HUMAN;tr|A0A087WV73|A0A087WV73_HUMAN",1504,"P46087","NOP2_HUMAN","Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase",null,"NOP2"]
["21.466","22.7442","21.795","21.1796",{"$nulls":3},"cell cycle;cell division;chromosome segregation;lysosome localization;small GTPase mediated signal transduction","alpha-tubulin binding;beta-tubulin binding;GDP binding;GTP binding;GTPase activity","cytoplasm;extracellular exosome;late endosome membrane;lysosomal membrane;membrane;midbody;spindle midzone",{"$nulls":3},6,6,6,"30.6","30.6","30.6","21.539",0,"17.025",357940000,14,"0.322767",1,"0.617805","0.871001","sp|Q9NVJ2|ARL8B_HUMAN;sp|Q96BM9|ARL8A_HUMAN","sp|Q9NVJ2|ARL8B_HUMAN;sp|Q96BM9|ARL8A_HUMAN",4493,"Q9NVJ2","ARL8B_HUMAN","ADP-ribosylation factor-like protein 8B",null,"ARL8B"]
["19.9442","19.8827","19.9265","18.6732",{"$nulls":3},"mitochondrial tRNA 5'-end processing;mitochondrial tRNA processing;tRNA 5'-leader removal","metal ion binding;ribonuclease P activity","mitochondrial matrix;mitochondrial ribonuclease P complex;mitochondrion;nucleus",{"$nulls":3},5,5,5,"13.9","13.9","13.9","67.315",0,"22.015",242410000,18,"0.365313",1,"0.613587","0.978007","sp|O15091|MRRP3_HUMAN;tr|A0A0A0MTQ0|A0A0A0MTQ0_HUMAN","sp|O15091|MRRP3_HUMAN",322,"O15091","MRPP3_HUMAN","Mitochondrial ribonuclease P catalytic subunit",null,"KIAA0391"]
["16.176",1,"14.9542",1,{"$nulls":9},2,2,2,"11.6","11.6","11.6","30.492","0.0061704","2.6221",29343000,9,"0.0185755",1,"0.610911","0.0592649","tr|Q5HYY5|Q5HYY5_HUMAN;sp|Q96T21|SEBP2_HUMAN","tr|Q5HYY5|Q5HYY5_HUMAN;sp|Q96T21|SEBP2_HUMAN",3830,"Q5HYY5","Q5HYY5_HUMAN",null,null,"SECISBP2"]
["15.6965","16.1044","15.8542","14.7271",{"$nulls":3},"intracellular signal transduction;negative regulation of apoptotic process;negative regulation of insulin secretion involved in cellular response to glucose stimulus;negative regulation of neuron projection regeneration;neuron projection morphogenesis;protein phosphorylation;regulation of JNK cascade;regulation of mitotic cell cycle","ATP binding;creatine kinase activity;MAP kinase kinase kinase kinase activity;protein serine/threonine kinase activity","cytoplasm","MAPK signaling pathway",null,null,29,1,1,"25.4","1.2","1.2",145,0,"42.551",152440000,3,"0.380932",1,"0.609807","1.01749","tr|E7ESS2|E7ESS2_HUMAN;tr|E7EN19|E7EN19_HUMAN","tr|E7ESS2|E7ESS2_HUMAN;tr|E7EN19|E7EN19_HUMAN",5200,"E7ESS2","M4K4_HUMAN","Mitogen-activated protein kinase kinase kinase kinase 4",null,"MAP4K4"]
["20.2885","19.4403","19.5722","18.9413",{"$nulls":3},"cell-cell junction assembly;cell-cell signaling involved in cell-cell junction organization;establishment of endothelial intestinal barrier;hippo signaling;regulation of bicellular tight junction assembly","cadherin binding;calmodulin binding","apical junction complex;apical part of cell;basolateral plasma membrane;bicellular tight junction;cell junction;cell-cell adherens junction;cytoplasm;cytosol;gap junction;plasma membrane","Adherens junction;Epithelial cell signaling in Helicobacter pylori infection;Gap junction;Salmonella infection;Tight junction;Vibrio cholerae infection",null,null,35,35,35,"30.1","30.1","30.1","195.46",0,"116.17",1304700000,168,"0.432755",1,"0.607667","1.14972","sp|Q07157|ZO1_HUMAN;tr|G3V1L9|G3V1L9_HUMAN;tr|A0A087X0K9|A0A087X0K9_HUMAN;tr|G5E9E7|G5E9E7_HUMAN;tr|H0YKB1|H0YKB1_HUMAN;tr|H0YLT6|H0YLT6_HUMAN;tr|H0Y3R8|H0Y3R8_HUMAN","sp|Q07157|ZO1_HUMAN;tr|G3V1L9|G3V1L9_HUMAN;tr|A0A087X0K9|A0A087X0K9_HUMAN;tr|G5E9E7|G5E9E7_HUMAN",2119,"Q07157","ZO1_HUMAN","Tight junction protein ZO-1",null,"TJP1"]
["17.604","19.4792","17.948","17.9258",{"$nulls":3},"axon extension;BMP signaling pathway;cell cycle;cell division;cellular protein metabolic process;chromosome segregation;female gamete generation;negative regulation of transcription from RNA polymerase II promoter;neuron migration;protein deubiquitination;protein ubiquitination;transforming growth factor beta receptor signaling pathway;ubiquitin-dependent protein catabolic process","co-SMAD binding;cysteine-type endopeptidase activity;cysteine-type peptidase activity;thiol-dependent ubiquitinyl hydrolase activity","cytoplasm;cytosol;growth cone;membrane",{"$nulls":3},9,9,9,5,5,5,"292.28",0,"31.906",332880000,27,"0.23277",1,"0.604669","0.644882","sp|Q93008|USP9X_HUMAN;sp|O00507|USP9Y_HUMAN","sp|Q93008|USP9X_HUMAN",3564,"Q93008","USP9X_HUMAN","Probable ubiquitin carboxyl-terminal hydrolase FAF-X",null,"USP9X"]
["16.3297","17.3792","16.7599","15.743",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;RNA splicing;RNA splicing, via transesterification reactions;spliceosomal tri-snRNP complex assembly","identical protein binding;RNA binding","Cajal body;cytosol;nuclear speck;nucleoplasm;nucleus;protein complex;spliceosomal complex;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,15,15,15,"31.5","31.5","31.5","77.528",0,"57.668",716500000,69,"0.304521",1,"0.602988","0.825249","sp|O43395|PRPF3_HUMAN","sp|O43395|PRPF3_HUMAN",395,"O43395","PRPF3_HUMAN","U4/U6 small nuclear ribonucleoprotein Prp3",null,"PRPF3"]
["16.9173","17.8061","16.6908","16.8266",{"$nulls":4},"actin binding;protein phosphatase inhibitor activity",{"$nulls":4},2,2,2,"4.5","4.5","4.5","68.295","0.00046718","4.9077",20153000,5,"0.506042",1,"0.602979","1.34125","tr|J3KP75|J3KP75_HUMAN;sp|O75167|PHAR2_HUMAN","tr|J3KP75|J3KP75_HUMAN;sp|O75167|PHAR2_HUMAN",533,"J3KP75","J3KP75_HUMAN","Phosphatase and actin regulator {ECO:0000256|RuleBase:RU301113}",null,"PHACTR2"]
["20.6939","20.7824","20.8586","19.4123",{"$nulls":3},"aging;apoptotic mitochondrial changes;cell redox homeostasis;cellular response to fibroblast growth factor stimulus;cellular response to follicle-stimulating hormone stimulus;cellular response to glucose stimulus;cellular response to hepatocyte growth factor stimulus;cellular response to insulin stimulus;cellular response to mechanical stimulus;cellular response to thyroxine stimulus;cysteine metabolic process;glutamate metabolic process;glutathione biosynthetic process;L-ascorbic acid metabolic process;negative regulation of apoptotic process;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of hepatic stellate cell activation;negative regulation of neuron apoptotic process;negative regulation of protein ubiquitination;negative regulation of transcription, DNA-templated;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;regulation of blood vessel size;regulation of mitochondrial depolarization;response to activity;response to arsenic-containing substance;response to cadmium ion;response to heat;response to hormone;response to human chorionic gonadotropin;response to interleukin-1;response to nitrosative stress;response to nutrient;response to oxidative stress;response to xenobiotic stimulus","ADP binding;ATP binding;coenzyme binding;glutamate binding;glutamate-cysteine ligase activity;magnesium ion binding;protein heterodimerization activity","cytosol;glutamate-cysteine ligase complex","Cysteine and methionine metabolism;Ferroptosis;Glutathione metabolism;Metabolic pathways",null,null,12,12,12,"26.8","26.8","26.8","72.765",0,"41.233",405970000,46,"0.307158",1,"0.602712","0.831858","sp|P48506|GSH1_HUMAN;tr|E1CEI4|E1CEI4_HUMAN;tr|A0A0C4DGB2|A0A0C4DGB2_HUMAN;tr|D6R959|D6R959_HUMAN;tr|D6RGF8|D6RGF8_HUMAN;tr|H0Y9I7|H0Y9I7_HUMAN;tr|D6REX4|D6REX4_HUMAN","sp|P48506|GSH1_HUMAN;tr|E1CEI4|E1CEI4_HUMAN;tr|A0A0C4DGB2|A0A0C4DGB2_HUMAN",1543,"P48506","GSH1_HUMAN","Glutamate--cysteine ligase catalytic subunit",null,"GCLC"]
["15.1904","15.3769","15.7533","13.6102",{"$nulls":3},"establishment of Golgi localization;Golgi organization;maintenance of Golgi location;organelle transport along microtubule;positive regulation of GTPase activity;regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity","actin cytoskeleton;cell junction;cytoplasmic vesicle membrane;cytosol;Golgi apparatus;Golgi membrane;plasma membrane",{"$nulls":3},8,8,8,"7.6","7.6","7.6","217.33",0,"19.418",127860000,29,"0.199239",1,"0.601902","0.559595","sp|Q5T5U3|RHG21_HUMAN;tr|E7ESW5|E7ESW5_HUMAN;tr|F8W9U9|F8W9U9_HUMAN;tr|A0A087WW76|A0A087WW76_HUMAN","sp|Q5T5U3|RHG21_HUMAN;tr|E7ESW5|E7ESW5_HUMAN;tr|F8W9U9|F8W9U9_HUMAN;tr|A0A087WW76|A0A087WW76_HUMAN",2730,"Q5T5U3","RHG21_HUMAN","Rho GTPase-activating protein 21",null,"ARHGAP21"]
["15.7608","17.2278","15.8204","15.9657",{"$nulls":3},"cellular response to interleukin-4;cytoplasmic sequestering of transcription factor;in utero embryonic development;negative regulation of DNA binding transcription factor activity;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;post-translational protein modification;proteasomal ubiquitin-independent protein catabolic process;protein deubiquitination;protein ubiquitination;regulation of epidermal cell differentiation;transcription, DNA-templated","disordered domain specific binding;protein homodimerization activity;transcription factor binding","actin filament;Cul3-RING ubiquitin ligase complex;cytoplasm;cytosol;endoplasmic reticulum;microtubule organizing center;midbody;nucleoplasm;protein complex","Fluid shear stress and atherosclerosis;Hepatocellular carcinoma;Pathways in cancer;Ubiquitin mediated proteolysis",null,null,6,6,6,"10.9","10.9","10.9","69.666",0,"8.5568",42932000,9,"0.300715",1,"0.601243","0.815706","sp|Q14145|KEAP1_HUMAN;tr|K7ESE0|K7ESE0_HUMAN;tr|K7EPZ3|K7EPZ3_HUMAN;tr|K7EQX2|K7EQX2_HUMAN;tr|K7EJ49|K7EJ49_HUMAN;tr|K7EJD8|K7EJD8_HUMAN","sp|Q14145|KEAP1_HUMAN",2333,"Q14145","KEAP1_HUMAN","Kelch-like ECH-associated protein 1",null,"KEAP1"]
["18.6538","19.1143","19.4776","17.1014",{"$nulls":4},"calcium ion binding",{"$nulls":4},10,10,10,"20.2","20.2","20.2","83.474",0,"33.13",192340000,35,"0.172703",1,"0.594469","0.491214","tr|M0R165|M0R165_HUMAN;sp|Q9UBC2|EP15R_HUMAN;tr|M0R2S2|M0R2S2_HUMAN;tr|K7EJR2|K7EJR2_HUMAN;tr|M0R330|M0R330_HUMAN;tr|M0QX30|M0QX30_HUMAN;tr|M0R1V5|M0R1V5_HUMAN;tr|M0R3I1|M0R3I1_HUMAN","tr|M0R165|M0R165_HUMAN;sp|Q9UBC2|EP15R_HUMAN;tr|M0R2S2|M0R2S2_HUMAN",4657,"M0R165","M0R165_HUMAN",null,null,"EPS15L1"]
["22.4392","21.4947","22.5366","20.2088",{"$nulls":3},"rRNA processing","bent DNA binding;DNA binding;double-stranded DNA binding;peptidyl-prolyl cis-trans isomerase activity;RNA binding","cytoplasm;extracellular exosome;mitochondrial matrix;nucleolus;nucleus;preribosome;spindle",{"$nulls":3},3,3,3,"32.1","32.1","32.1","13.81",0,"12.516",304650000,13,"0.165733",1,"0.594218","0.473085","sp|Q9Y237|PIN4_HUMAN;tr|H0Y4T6|H0Y4T6_HUMAN;tr|J3KMW3|J3KMW3_HUMAN;tr|H0Y8P6|H0Y8P6_HUMAN;tr|H0Y610|H0Y610_HUMAN","sp|Q9Y237|PIN4_HUMAN",4892,"Q9Y237","PIN4_HUMAN","Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4",null,"PIN4"]
["16.5944","15.5494","15.7704","15.1874",{"$nulls":3},"axon guidance;B cell differentiation;cellular glucose homeostasis;cellular response to insulin stimulus;cellular response to UV;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;extrinsic apoptotic signaling pathway via death domain receptors;Fc-epsilon receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;G-protein coupled receptor signaling pathway;growth hormone receptor signaling pathway;insulin receptor signaling pathway;insulin-like growth factor receptor signaling pathway;interleukin-7-mediated signaling pathway;intrinsic apoptotic signaling pathway in response to DNA damage;leukocyte migration;negative regulation of apoptotic process;negative regulation of cell-matrix adhesion;negative regulation of osteoclast differentiation;NFAT protein import into nucleus;phosphatidylinositol 3-kinase signaling;phosphatidylinositol biosynthetic process;phosphatidylinositol phosphorylation;phosphatidylinositol-mediated signaling;platelet activation;positive regulation of cell migration;positive regulation of endoplasmic reticulum unfolded protein response;positive regulation of glucose import;positive regulation of glucose import in response to insulin stimulus;positive regulation of protein kinase B signaling;positive regulation of protein localization to plasma membrane;positive regulation of RNA splicing;positive regulation of transcription factor import into nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor production;protein phosphorylation;protein stabilization;regulation of insulin receptor signaling pathway;regulation of phosphatidylinositol 3-kinase activity;regulation of stress fiber assembly;response to endoplasmic reticulum stress;T cell costimulation;T cell receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway;viral process","1-phosphatidylinositol-3-kinase activity;1-phosphatidylinositol-3-kinase regulator activity;ErbB-3 class receptor binding;insulin binding;insulin receptor binding;insulin receptor substrate binding;insulin-like growth factor receptor binding;neurotrophin TRKA receptor binding;phosphatidylinositol 3-kinase binding;phosphatidylinositol 3-kinase regulator activity;phosphatidylinositol 3-kinase regulatory subunit binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;phosphotyrosine residue binding;protein heterodimerization activity;protein phosphatase binding;transcription factor binding;transmembrane receptor protein tyrosine kinase adaptor activity","cell-cell junction;cis-Golgi network;cytoplasm;cytosol;membrane;nucleus;perinuclear endoplasmic reticulum membrane;phosphatidylinositol 3-kinase complex;phosphatidylinositol 3-kinase complex, class IA;plasma membrane;protein complex","Acute myeloid leukemia;AGE-RAGE signaling pathway in diabetic complications;Aldosterone-regulated sodium reabsorption;Amoebiasis;AMPK signaling pathway;Apoptosis;Autophagy - animal;Axon guidance;B cell receptor signaling pathway;Bacterial invasion of epithelial cells;Breast cancer;cAMP signaling pathway;Carbohydrate digestion and absorption;Cellular senescence;Central carbon metabolism in cancer;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;C-type lectin receptor signaling pathway;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;Epstein-Barr virus infection;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Insulin signaling pathway;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leukocyte transendothelial migration;Longevity regulating pathway;Longevity regulating pathway - multiple species;Measles;Melanoma;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Non-small cell lung cancer;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Platelet activation;Platinum drug resistance;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Signaling pathways regulating pluripotency of stem cells;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid hormone signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Type II diabetes mellitus;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,2,2,2,"4.4","4.4","4.4","83.597","0.001507","3.6168",11995000,3,"0.370512",1,"0.593006","0.991135","sp|P27986|P85A_HUMAN;tr|E5RHI0|E5RHI0_HUMAN;tr|E5RGI8|E5RGI8_HUMAN","sp|P27986|P85A_HUMAN;tr|E5RHI0|E5RHI0_HUMAN;tr|E5RGI8|E5RGI8_HUMAN",1260,"P27986","P85A_HUMAN","Phosphatidylinositol 3-kinase regulatory subunit alpha","I3K regulatory subunit alpha;I3-kinase regulatory subunit alpha;tdIns-3-kinase regulatory subunit alpha","PIK3R1"]
["17.0555","17.6002","17.3556","16.1142",{"$nulls":3},"microtubule-based movement","ATP binding;ATPase activity;microtubule binding;microtubule motor activity","cytoplasm;kinesin complex;microtubule",{"$nulls":3},7,7,7,6,6,6,"187.18",0,"34.201",123740000,29,"0.324266",1,"0.592943","0.874761","sp|Q7Z4S6|KI21A_HUMAN;tr|H0YHT2|H0YHT2_HUMAN;tr|H0YIM6|H0YIM6_HUMAN;tr|H0YIM7|H0YIM7_HUMAN","sp|Q7Z4S6|KI21A_HUMAN;tr|H0YHT2|H0YHT2_HUMAN",3006,"Q7Z4S6","KI21A_HUMAN","Kinesin-like protein KIF21A",null,"KIF21A"]
["15.116","15.9862","15.2526","14.6667",{"$nulls":3},"cellular response to cAMP;cellular response to ethanol;platelet activation;regulation of cardiac conduction;regulation of insulin secretion;release of sequestered calcium ion into cytosol;response to hypoxia;signal transduction;transport","calcium ion binding;calcium ion transmembrane transporter activity;inositol 1,4,5 trisphosphate binding;inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;phosphatidylinositol binding;scaffold protein binding","cell cortex;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;nucleus;plasma membrane;platelet dense tubular network membrane;receptor complex;sarcoplasmic reticulum membrane","Aldosterone synthesis and secretion;Alzheimer disease;Apelin signaling pathway;Apoptosis;Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Cholinergic synapse;Cortisol synthesis and secretion;C-type lectin receptor signaling pathway;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;NOD-like receptor signaling pathway;Oocyte meiosis;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Phosphatidylinositol signaling system;Platelet activation;Proteoglycans in cancer;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Thyroid hormone synthesis;Vascular smooth muscle contraction",null,null,6,6,6,"3.4","3.4","3.4","308.06",0,"19.71",59942000,19,"0.424178",1,"0.591492","1.12768","sp|Q14571|ITPR2_HUMAN","sp|Q14571|ITPR2_HUMAN",2371,"Q14571","ITPR2_HUMAN","Inositol 1,4,5-trisphosphate receptor type 2",null,"ITPR2"]
["19.5704","18.6237","19.5604","17.4536",{"$nulls":4},"metal ion binding",{"$nulls":4},3,3,3,25,25,25,"20.6",0,"12.171",23343000,6,"0.180327",1,"0.590073","0.51096","tr|H0YFA4|H0YFA4_HUMAN;sp|P52943|CRIP2_HUMAN","tr|H0YFA4|H0YFA4_HUMAN;sp|P52943|CRIP2_HUMAN",1702,"H0YFA4","H0YFA4_HUMAN",null,null,"CRIP2"]
["23.4307","23.2479","23.2456","22.2529",{"$nulls":3},"protein N-linked glycosylation via asparagine","transferase activity, transferring glycosyl groups","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},13,13,13,"44.6","44.6","44.6","48.799",0,"323.31",2249800000,116,"0.440299",1,"0.590056","1.16916","tr|A0A0C4DGS1|A0A0C4DGS1_HUMAN;sp|P39656|OST48_HUMAN;tr|U3KQ84|U3KQ84_HUMAN","tr|A0A0C4DGS1|A0A0C4DGS1_HUMAN;sp|P39656|OST48_HUMAN",1431,"A0A0C4DGS1","A0A0C4DGS1_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit {ECO:0000256|RuleBase:RU361142}","ligosaccharyl transferase 48 kDa subunit {ECO:0000256|RuleBase:RU361142}","DDOST"]
["18.2318","17.6953","17.7441","17.0034",{"$nulls":3},"adrenergic receptor signaling pathway;adrenergic receptor signaling pathway involved in heart process;bone development;cardiac muscle cell differentiation;G-protein coupled receptor signaling pathway;heart development;intracellular signal transduction;nuclear export;positive regulation of apoptotic process;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of MAP kinase activity;positive regulation of Rho protein signal transduction;regulation of cardiac muscle hypertrophy;regulation of glucocorticoid mediated signaling pathway;regulation of sarcomere organization;regulation of small GTPase mediated signal transduction","cAMP-dependent protein kinase activity;guanyl-nucleotide exchange factor activity;MAP-kinase scaffold activity;metal ion binding;protein complex scaffold activity;protein kinase A binding;Rho GTPase binding;Rho guanyl-nucleotide exchange factor activity;signal transducer activity","actin filament;cell cortex;cytosol;membrane;nucleus;perinuclear region of cytoplasm","Human cytomegalovirus infection;Parathyroid hormone synthesis, secretion and action",null,null,58,58,58,"29.1","29.1","29.1","307.55",0,"323.31",2532300000,370,"0.486585",1,"0.589801","1.28977","sp|Q12802|AKP13_HUMAN;tr|H0YMW2|H0YMW2_HUMAN;tr|A0A087WTD7|A0A087WTD7_HUMAN;tr|A8MYJ1|A8MYJ1_HUMAN;tr|A0A087WY36|A0A087WY36_HUMAN;tr|H0YLH1|H0YLH1_HUMAN;tr|A0A087WX73|A0A087WX73_HUMAN;tr|A0A087X047|A0A087X047_HUMAN","sp|Q12802|AKP13_HUMAN;tr|H0YMW2|H0YMW2_HUMAN;tr|A0A087WTD7|A0A087WTD7_HUMAN;tr|A8MYJ1|A8MYJ1_HUMAN",2162,"Q12802","AKP13_HUMAN","A-kinase anchor protein 13","KAP-13","AKAP13"]
["21.9692","21.6478","21.6944","20.7466",{"$nulls":3},"cellular amino acid metabolic process;xenobiotic metabolic process","aminoacylase activity;identical protein binding;metal ion binding;metallopeptidase activity","cytosol;extracellular exosome","2-Oxocarboxylic acid metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Metabolic pathways",null,null,10,10,10,"34.3","34.3","34.3","45.884",0,"147.16",666100000,48,"0.442582",1,"0.588023","1.17505","sp|Q03154|ACY1_HUMAN;tr|C9JMV9|C9JMV9_HUMAN;tr|C9JYZ0|C9JYZ0_HUMAN;tr|F8WC59|F8WC59_HUMAN","sp|Q03154|ACY1_HUMAN;tr|C9JMV9|C9JMV9_HUMAN;tr|C9JYZ0|C9JYZ0_HUMAN;tr|F8WC59|F8WC59_HUMAN",2080,"Q03154","ACY1_HUMAN","Aminoacylase-1","CY-1","ACY1"]
["23.6287","22.2374","23.0876","21.6033",{"$nulls":3},"ERBB signaling pathway;mRNA transport;negative regulation of protein autophosphorylation;negative regulation of protein tyrosine kinase activity;negative regulation of signaling;neutrophil degranulation;protein transport","identical protein binding;protein kinase binding;protein phosphatase binding","cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular ribonucleoprotein complex;membrane;nuclear pore;nucleus;perinuclear region of cytoplasm;secretory granule lumen",{"$nulls":3},34,34,34,"53.1","53.1","53.1","99.326",0,"291.81",2544400000,169,"0.206301",1,"0.58758","0.577647","sp|Q14764|MVP_HUMAN;tr|H3BQK6|H3BQK6_HUMAN;tr|H3BRL2|H3BRL2_HUMAN;tr|H3BUK7|H3BUK7_HUMAN;tr|H3BNF6|H3BNF6_HUMAN;tr|H3BP76|H3BP76_HUMAN;tr|H3BPZ2|H3BPZ2_HUMAN;tr|H3BNF2|H3BNF2_HUMAN;tr|H3BUP3|H3BUP3_HUMAN;tr|H3BQE7|H3BQE7_HUMAN","sp|Q14764|MVP_HUMAN",2394,"Q14764","MVP_HUMAN","Major vault protein","VP","MVP"]
["17.3957","19.7328","18.7791","17.1777",{"$nulls":3},"methylation;ubiquinone biosynthetic process","2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity","mitochondrial inner membrane;mitochondrial matrix;protein complex","Metabolic pathways;Ubiquinone and other terpenoid-quinone biosynthesis",null,null,5,5,5,"18.3","18.3","18.3","37.14",0,"17.969",198110000,34,"0.143066",1,"0.585812","0.413535","sp|Q5HYK3|COQ5_HUMAN;tr|F8VVX6|F8VVX6_HUMAN;tr|F8VP53|F8VP53_HUMAN;tr|F8VVW7|F8VVW7_HUMAN;tr|B4DP72|B4DP72_HUMAN","sp|Q5HYK3|COQ5_HUMAN;tr|F8VVX6|F8VVX6_HUMAN;tr|F8VP53|F8VP53_HUMAN;tr|F8VVW7|F8VVW7_HUMAN",2691,"Q5HYK3","COQ5_HUMAN","2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03191}",null,"COQ5"]
["16.0109","16.6862","16.125","15.4006",{"$nulls":3},"cell adhesion;cell migration;cellular protein metabolic process;endoderm development;extracellular matrix disassembly;extracellular matrix organization;hemidesmosome assembly;positive regulation of epithelial cell proliferation;post-translational protein modification;protein complex assembly;substrate adhesion-dependent cell spreading","extracellular matrix structural constituent","basement membrane;endoplasmic reticulum lumen;extracellular exosome;extracellular matrix;extracellular region;extracellular space;laminin-1 complex;laminin-10 complex;laminin-11 complex","Amoebiasis;ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Pathways in cancer;PI3K-Akt signaling pathway;Prion diseases;Small cell lung cancer;Toxoplasmosis",null,null,3,3,3,"2.4","2.4","2.4","177.6","0.00067174","4.1728",33359000,3,"0.445647",1,"0.585759","1.18297","sp|P11047|LAMC1_HUMAN","sp|P11047|LAMC1_HUMAN",981,"P11047","LAMC1_HUMAN","Laminin subunit gamma-1",null,"LAMC1"]
["17.267","17.1612","17.2281","16.0294",{"$nulls":3},"ion transport",null,"integral component of membrane;membrane;plasma membrane",{"$nulls":3},3,3,3,"9.5","9.5","9.5","76.118",0,"8.6411",46149000,5,"0.363307",1,"0.585408","0.972946","sp|Q8NE01|CNNM3_HUMAN","sp|Q8NE01|CNNM3_HUMAN",3321,"Q8NE01","CNNM3_HUMAN","Metal transporter CNNM3",null,"CNNM3"]
[1,"16.7603",1,"15.5954",{"$nulls":3},"adaptive immune response;angiogenesis;antigen processing and presentation of endogenous peptide antigen via MHC class I;antigen processing and presentation of peptide antigen via MHC class I;cell-cell signaling;fat cell differentiation;membrane protein ectodomain proteolysis;peptide catabolic process;positive regulation of angiogenesis;regulation of blood pressure;regulation of innate immune response;response to bacterium;signal transduction","aminopeptidase activity;endopeptidase activity;interleukin-1, Type II receptor binding;interleukin-6 receptor binding;metalloaminopeptidase activity;metalloexopeptidase activity;peptide binding;zinc ion binding","cytosol;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular exosome;extracellular region;extracellular space;integral component of membrane;membrane;plasma membrane",{"$nulls":3},2,2,2,"2.3","2.3","2.3","107.23","0.00066563","4.0584",12304000,4,"0.0169692",1,"0.582464","0.0542317","sp|Q9NZ08|ERAP1_HUMAN","sp|Q9NZ08|ERAP1_HUMAN",4580,"Q9NZ08","ERAP1_HUMAN","Endoplasmic reticulum aminopeptidase 1",null,"ERAP1"]
["19.1228","19.3449","19.3243","17.9803",{"$nulls":3},"mitochondrion organization;transcription from mitochondrial promoter;transcription initiation from mitochondrial promoter","DNA binding;DNA-directed 5'-3' RNA polymerase activity;RNA binding","mitochondrial DNA-directed RNA polymerase complex;mitochondrial matrix;mitochondrial nucleoid;mitochondrion",{"$nulls":3},26,26,26,"28.8","28.8","28.8","138.62",0,"120.86",850930000,105,"0.31591",1,"0.581554","0.853801","sp|O00411|RPOM_HUMAN;tr|K7EMH3|K7EMH3_HUMAN;tr|K7ESD1|K7ESD1_HUMAN","sp|O00411|RPOM_HUMAN",221,"O00411","RPOM_HUMAN","DNA-directed RNA polymerase, mitochondrial","tRPOL","POLRMT"]
["19.9536","20.6377","20.2294","19.2014",{"$nulls":3},"activation of MAPK activity;activation of protein kinase activity;cardiac muscle contraction;inflammatory response;positive regulation of protein kinase activity;positive regulation of transcription, DNA-templated;proteolysis in other organism;regulation of apoptotic process;regulation of cytokine biosynthetic process;regulation of mitotic cell cycle;signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;MAP kinase kinase activity;protein kinase binding;protein serine/threonine kinase activity;protein tyrosine kinase activity","cytoplasm;cytosol;membrane;nucleoplasm","Amyotrophic lateral sclerosis (ALS);Cellular senescence;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;GnRH signaling pathway;Hepatitis B;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;MAPK signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Rap1 signaling pathway;Thermogenesis;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Yersinia infection",null,null,13,13,10,"41.5","41.5","34.9","39.318",0,"80.665",1148000000,104,"0.350162",1,"0.580261","0.939824","sp|P46734|MP2K3_HUMAN;tr|E9PRZ0|E9PRZ0_HUMAN;tr|J3QR49|J3QR49_HUMAN;tr|J3KRV4|J3KRV4_HUMAN;tr|X6RB39|X6RB39_HUMAN;tr|J3QL77|J3QL77_HUMAN;tr|E9PMA8|E9PMA8_HUMAN","sp|P46734|MP2K3_HUMAN",1511,"P46734","MP2K3_HUMAN","Dual specificity mitogen-activated protein kinase kinase 3","AP kinase kinase 3;APKK 3","MAP2K3"]
["20.3874","20.8875","20.2476","19.8674",{"$nulls":5},"integral component of membrane",{"$nulls":3},8,8,8,"15.6","15.6","15.6","67.887",0,"21.193",268940000,26,"0.685927",1,"0.579935","1.84649","sp|Q9HD45|TM9S3_HUMAN;tr|Q5TB53|Q5TB53_HUMAN","sp|Q9HD45|TM9S3_HUMAN;tr|Q5TB53|Q5TB53_HUMAN",4344,"Q9HD45","TM9S3_HUMAN","Transmembrane 9 superfamily member 3",null,"TM9SF3"]
["19.6756","20.1089","19.909","18.7189",{"$nulls":3},"gamma-aminobutyric acid catabolic process","succinate-semialdehyde dehydrogenase [NAD(P)+] activity","mitochondrion",{"$nulls":3},7,7,7,"24.5","24.5","24.5","53.867",0,"31.601",168370000,19,"0.33958",1,"0.578315","0.913212","tr|C9J8Q5|C9J8Q5_HUMAN;sp|P51649|SSDH_HUMAN","tr|C9J8Q5|C9J8Q5_HUMAN;sp|P51649|SSDH_HUMAN",1663,"C9J8Q5","C9J8Q5_HUMAN",null,null,"ALDH5A1"]
["20.4579","21.4908","20.7517","20.0438",{"$nulls":3},"prenylated protein catabolic process;prenylcysteine catabolic process;prenylcysteine metabolic process","chloride-transporting ATPase activity;prenylcysteine oxidase activity","extracellular exosome;lysosome;plasma membrane;vacuolar membrane;very-low-density lipoprotein particle","Terpenoid backbone biosynthesis",null,null,9,9,9,"21.8","21.8","21.8","56.639",0,"34.356",293370000,26,"0.342659",1,"0.576588","0.920952","sp|Q9UHG3|PCYOX_HUMAN;tr|F8W8W4|F8W8W4_HUMAN;tr|C9K055|C9K055_HUMAN;tr|C9JGT6|C9JGT6_HUMAN;tr|C9JM55|C9JM55_HUMAN","sp|Q9UHG3|PCYOX_HUMAN;tr|F8W8W4|F8W8W4_HUMAN",4725,"Q9UHG3","PCYOX_HUMAN","Prenylcysteine oxidase 1",null,"PCYOX1"]
["17.869","17.0755","17.9762","15.8156",{"$nulls":3},"cellular sodium ion homeostasis;excretion;ion transmembrane transport;negative regulation of potassium ion transmembrane transport;negative regulation of potassium ion transmembrane transporter activity;negative regulation of protein localization to cell surface;negative regulation of sodium ion transmembrane transport;negative regulation of sodium ion transmembrane transporter activity;negative regulation of transcription from RNA polymerase II promoter;positive regulation of caveolin-mediated endocytosis;positive regulation of dendrite extension;positive regulation of endocytosis;positive regulation of protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K48-linked ubiquitination;protein monoubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of ion transmembrane transport;regulation of membrane depolarization;regulation of membrane potential;regulation of membrane repolarization;regulation of potassium ion transmembrane transporter activity;regulation of protein catabolic process;response to metal ion;sodium ion transport;ventricular cardiac muscle cell action potential;viral life cycle;water homeostasis","ion channel binding;potassium channel inhibitor activity;potassium channel regulator activity;sodium channel inhibitor activity;sodium channel regulator activity;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;Golgi apparatus;intracellular;multivesicular body;nucleoplasm","Aldosterone-regulated sodium reabsorption;Endocytosis;Tight junction;Ubiquitin mediated proteolysis",null,null,6,5,5,"8.1","7.1","7.1","111.93",0,"17.485",85932000,20,"0.176397",1,"0.576327","0.500792","sp|Q96PU5|NED4L_HUMAN;tr|K7ERN1|K7ERN1_HUMAN;tr|H0Y8H4|H0Y8H4_HUMAN","sp|Q96PU5|NED4L_HUMAN;tr|K7ERN1|K7ERN1_HUMAN",3786,"Q96PU5","NED4L_HUMAN","E3 ubiquitin-protein ligase NEDD4-like",null,"NEDD4L"]
[1,"17.937",1,"16.7856",{"$nulls":3},"retrograde transport, endosome to Golgi",null,"cytosol;Golgi cisterna membrane;integral component of membrane",{"$nulls":3},2,2,2,"4.7","4.7","4.7","63.429","0.0002572","6.9677",17826000,5,"0.015538",1,"0.57573","0.0497333","sp|Q8NBN3|TM87A_HUMAN","sp|Q8NBN3|TM87A_HUMAN",3288,"Q8NBN3","TM87A_HUMAN","Transmembrane protein 87A {ECO:0000305}",null,"TMEM87A"]
[1,"20.4971","19.3465",1,{"$nulls":9},3,3,3,"51.5","51.5","51.5","11.705",0,"36.292",341330000,20,"0.0133957",1,"0.57526","0.042975","sp|Q9BU68|PR15L_HUMAN","sp|Q9BU68|PR15L_HUMAN",3979,"Q9BU68","PR15L_HUMAN","Proline-rich protein 15-like protein",null,"PRR15L"]
["19.0067","20.4893","19.0331","19.3125",{"$nulls":3},"vesicle-mediated transport",null,"TRAPP complex",{"$nulls":3},2,2,2,"26.5","26.5","26.5","13.021",0,"13.253",39001000,8,"0.279523",1,"0.575256","0.762569","tr|G3V1A0|G3V1A0_HUMAN;tr|G5EA23|G5EA23_HUMAN;tr|J3KP27|J3KP27_HUMAN;sp|Q9Y296|TPPC4_HUMAN;tr|E9PN70|E9PN70_HUMAN;tr|E9PKS9|E9PKS9_HUMAN;tr|E9PQE8|E9PQE8_HUMAN","tr|G3V1A0|G3V1A0_HUMAN;tr|G5EA23|G5EA23_HUMAN;tr|J3KP27|J3KP27_HUMAN;sp|Q9Y296|TPPC4_HUMAN;tr|E9PN70|E9PN70_HUMAN;tr|E9PKS9|E9PKS9_HUMAN;tr|E9PQE8|E9PQE8_HUMAN",4908,"G3V1A0","G3V1A0_HUMAN",null,null,"TRAPPC4"]
["15.5351","16.8129","15.2659","15.9343",{"$nulls":4},"actin filament binding",{"$nulls":4},5,5,5,11,11,11,"83.238",0,"11.627",317050000,15,"0.292846",1,"0.573915","0.795981","tr|A6NN40|A6NN40_HUMAN;sp|Q2M3G4|SHRM1_HUMAN;tr|C9JXU1|C9JXU1_HUMAN","tr|A6NN40|A6NN40_HUMAN;sp|Q2M3G4|SHRM1_HUMAN;tr|C9JXU1|C9JXU1_HUMAN",2595,"A6NN40","A6NN40_HUMAN",null,null,"SHROOM1"]
["17.9113","17.5255","18.2466","16.0432",{"$nulls":4},"metal ion binding",{"$nulls":4},4,4,4,"7.3","7.3","7.3","77.667",0,"22.775",90101000,13,"0.181031",1,"0.573525","0.512779","sp|Q8ND24|RN214_HUMAN;tr|E9PRE9|E9PRE9_HUMAN;tr|E9PN76|E9PN76_HUMAN","sp|Q8ND24|RN214_HUMAN",3311,"Q8ND24","RN214_HUMAN","RING finger protein 214",null,"RNF214"]
["16.95","19.6935","17.5395","17.9597",{"$nulls":4},"methyltransferase activity",{"$nulls":4},20,20,20,"42.5","42.5","42.5","78.767",0,"111.57",953310000,108,"0.142591",1,"0.572124","0.412278","sp|Q8N6R0|MET13_HUMAN","sp|Q8N6R0|MET13_HUMAN",3256,"Q8N6R0","MET13_HUMAN","Methyltransferase-like protein 13",null,"METTL13"]
["17.686","19.1825","18.0467","17.684",{"$nulls":3},"endocytosis;phosphatidylinositol biosynthetic process;regulation of endocytosis","lipid binding;metal ion binding;protein transporter activity;SH2 domain binding;SH3 domain binding","cytosol;early endosome membrane;endosome;intracellular membrane-bounded organelle;nuclear speck","Endocytosis",null,null,7,7,4,"13.6","13.6","9.3","79.817",0,"9.1566",91744000,7,"0.270092",1,"0.568892","0.738898","sp|Q96T51|RUFY1_HUMAN;tr|H0YAC8|H0YAC8_HUMAN;tr|J3KPP6|J3KPP6_HUMAN;tr|H0Y9Y8|H0Y9Y8_HUMAN","sp|Q96T51|RUFY1_HUMAN",3833,"Q96T51","RUFY1_HUMAN","RUN and FYVE domain-containing protein 1",null,"RUFY1"]
["22.632","23.5476","22.8996","22.1425",{"$nulls":3},"activation of JUN kinase activity;fatty acid elongation;I-kappaB kinase/NF-kappaB signaling;positive regulation by virus of viral protein levels in host cell;positive regulation of viral genome replication;Rac protein signal transduction;Rho protein signal transduction;small GTPase mediated signal transduction;sphingolipid biosynthetic process;very long-chain fatty acid biosynthetic process","3-hydroxyacyl-CoA dehydratase activity;3-hydroxy-arachidoyl-CoA dehydratase activity;3-hydroxy-behenoyl-CoA dehydratase activity;3-hydroxy-lignoceroyl-CoA dehydratase activity;enzyme binding;GTPase activator activity;very-long-chain 3-hydroxyacyl-CoA dehydratase activity","cytosol;endoplasmic reticulum;focal adhesion;integral component of endoplasmic reticulum membrane;mitochondrion;nuclear membrane","Biosynthesis of unsaturated fatty acids;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways",null,null,13,13,13,34,34,34,"43.159",0,"254.02",7981100000,275,"0.35715",1,"0.568728","0.957423","sp|Q9P035|HACD3_HUMAN;tr|H3BS72|H3BS72_HUMAN;tr|H3BPZ1|H3BPZ1_HUMAN;tr|H3BRL8|H3BRL8_HUMAN;tr|H3BMZ1|H3BMZ1_HUMAN","sp|Q9P035|HACD3_HUMAN;tr|H3BS72|H3BS72_HUMAN;tr|H3BPZ1|H3BPZ1_HUMAN",4613,"Q9P035","HACD3_HUMAN","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 {ECO:0000305}",null,"HACD3"]
["17.8546","19.2851","18.0118","17.991",{"$nulls":3},"brain development;homophilic cell adhesion via plasma membrane adhesion molecules;negative regulation of cell adhesion;neural tube closure;neuroblast proliferation;positive regulation of axonogenesis;positive regulation of neuron projection development;regulation of cell shape;regulation of GTPase activity;regulation of neuron migration;regulation of protein phosphorylation;semaphorin-plexin signaling pathway","semaphorin receptor activity","cell surface;extracellular exosome;integral component of plasma membrane","Axon guidance",null,null,17,17,17,"12.5","12.5","12.5","205.12",0,"49.846",294680000,28,"0.292337",1,"0.568493","0.794703","sp|O15031|PLXB2_HUMAN;tr|E2PU09|E2PU09_HUMAN;tr|A6QRH1|A6QRH1_HUMAN;tr|A6QRG9|A6QRG9_HUMAN;tr|H0Y6J7|H0Y6J7_HUMAN","sp|O15031|PLXB2_HUMAN",315,"O15031","PLXB2_HUMAN","Plexin-B2",null,"PLXNB2"]
[1,"14.273","13.1361",1,{"$nulls":3},"defense response to virus;fat cell differentiation;mRNA processing;negative regulation of viral genome replication;positive regulation of glucose import in response to insulin stimulus;positive regulation of transcription from RNA polymerase II promoter;protein phosphorylation;regulation of mRNA stability;regulation of type I interferon-mediated signaling pathway;rRNA processing;type I interferon signaling pathway","ATP binding;endoribonuclease activity;identical protein binding;metal ion binding;protein kinase activity;ribonucleoprotein complex binding;RNA binding;rRNA binding","cytosol;mitochondrial matrix;nuclear matrix","Hepatitis C;Herpes simplex virus 1 infection;Influenza A;NOD-like receptor signaling pathway",null,null,4,4,4,"6.3","6.3","6.3","83.532",0,"9.3066",118460000,17,"0.0198387",1,"0.568426","0.0632113","sp|Q05823|RN5A_HUMAN","sp|Q05823|RN5A_HUMAN",2105,"Q05823","RN5A_HUMAN","2-5A-dependent ribonuclease","-5A-dependent RNase","RNASEL"]
[1,"16.8527","15.7192",1,{"$nulls":3},"protein ADP-ribosylation","NAD+ ADP-ribosyltransferase activity","nucleolus;nucleus",{"$nulls":3},3,3,3,6,6,6,"60.214","0.0029215","3.229",45184000,6,"0.0163848",1,"0.566735","0.0523967","tr|G3V167|G3V167_HUMAN;sp|Q9UGN5|PARP2_HUMAN;tr|E9PJ27|E9PJ27_HUMAN;tr|H0YH02|H0YH02_HUMAN","tr|G3V167|G3V167_HUMAN;sp|Q9UGN5|PARP2_HUMAN",4706,"G3V167","G3V167_HUMAN","Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114}","ARP {ECO:0000256|RuleBase:RU362114}"]
["22.8268","22.3644","22.0319","22.0265",{"$nulls":3},"positive regulation of exoribonuclease activity;regulation of transcription, DNA-templated;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair","DNA binding;zinc ion binding","nucleolus;nucleoplasm;nucleus;transcription factor TFIID complex",{"$nulls":3},11,11,11,"45.8","45.8","45.8","33.969",0,"50.484",1015200000,57,"0.873029",1,"0.566401","2.44967","sp|P23193|TCEA1_HUMAN;tr|E5RIS7|E5RIS7_HUMAN;tr|E5RJ93|E5RJ93_HUMAN;tr|B7Z4S1|B7Z4S1_HUMAN;tr|A0A0A0MT58|A0A0A0MT58_HUMAN;sp|Q15560|TCEA2_HUMAN;tr|E5RK46|E5RK46_HUMAN;tr|E5RFI1|E5RFI1_HUMAN;tr|Q5JRI7|Q5JRI7_HUMAN","sp|P23193|TCEA1_HUMAN;tr|E5RIS7|E5RIS7_HUMAN",1190,"P23193","TCEA1_HUMAN","Transcription elongation factor A protein 1",null,"TCEA1"]
["22.6306","21.8135","22.648","20.666",{"$nulls":3},"apoptotic process;cellular response to transforming growth factor beta stimulus;negative regulation of cell proliferation;negative regulation of chaperone-mediated protein folding;positive regulation of apoptotic process;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of gene expression;positive regulation of protein import into mitochondrial outer membrane;positive regulation of release of cytochrome c from mitochondria","acetyltransferase activator activity;beta-tubulin binding;DNA binding;heparin binding","cytoplasm;cytosol;extracellular exosome;nucleus",{"$nulls":3},7,7,7,"60.8","60.8","60.8","14.285",0,"26.557",380980000,22,"0.186613",1,"0.565059","0.527175","sp|O14737|PDCD5_HUMAN;tr|K7ESJ4|K7ESJ4_HUMAN;tr|K7EQA1|K7EQA1_HUMAN;tr|Q3HM38|Q3HM38_HUMAN;tr|X6R2P6|X6R2P6_HUMAN","sp|O14737|PDCD5_HUMAN;tr|K7ESJ4|K7ESJ4_HUMAN;tr|K7EQA1|K7EQA1_HUMAN",277,"O14737","PDCD5_HUMAN","Programmed cell death protein 5",null,"PDCD5"]
["18.4609","17.8048","17.7211","17.4151",{"$nulls":3},"autophagy;mitotic chromosome condensation;negative regulation of autophagosome assembly;negative regulation of autophagosome maturation;positive regulation of protein ubiquitination","chromatin binding;metal ion binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"17.1","17.1","17.1","43.818",0,"21.641",184370000,28,"0.586533",1,"0.56472","1.56011","sp|Q9BUL5|PHF23_HUMAN;tr|I3L4Q4|I3L4Q4_HUMAN;tr|A0A087WVQ2|A0A087WVQ2_HUMAN;tr|I3L0Y2|I3L0Y2_HUMAN;tr|I3L410|I3L410_HUMAN;tr|I3L1N0|I3L1N0_HUMAN;tr|I3L0X3|I3L0X3_HUMAN;tr|I3L2W6|I3L2W6_HUMAN","sp|Q9BUL5|PHF23_HUMAN;tr|I3L4Q4|I3L4Q4_HUMAN;tr|A0A087WVQ2|A0A087WVQ2_HUMAN;tr|I3L0Y2|I3L0Y2_HUMAN;tr|I3L410|I3L410_HUMAN;tr|I3L1N0|I3L1N0_HUMAN",3988,"Q9BUL5","PHF23_HUMAN","PHD finger protein 23 {ECO:0000303|PubMed:25484098}",null,"PHF23"]
["20.1664","18.8132","18.7313","19.1209",{"$nulls":3},"activation of protein kinase B activity;fat cell differentiation;negative regulation of cell migration;negative regulation of sequestering of triglyceride;phosphatidylserine acyl-chain remodeling;phospholipid transport;positive regulation of glucose import in response to insulin stimulus;positive regulation of insulin receptor signaling pathway;positive regulation of protein kinase B signaling;protein localization to nuclear pore","cholesterol binding;phosphatidylinositol-4-phosphate binding;phosphatidylserine binding;phospholipid transporter activity","cortical endoplasmic reticulum;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;nuclear membrane",{"$nulls":3},30,30,25,"46.6","46.6","41.2","101.19",0,"323.31",4213100000,333,"0.294709",1,"0.563742","0.800651","sp|Q9BZF1|OSBL8_HUMAN;tr|F8VQX7|F8VQX7_HUMAN;tr|F8VUA7|F8VUA7_HUMAN;tr|F8VZ43|F8VZ43_HUMAN;tr|F8VZB8|F8VZB8_HUMAN;tr|F8VVD3|F8VVD3_HUMAN;tr|F8VVE7|F8VVE7_HUMAN","sp|Q9BZF1|OSBL8_HUMAN;tr|F8VQX7|F8VQX7_HUMAN;tr|F8VUA7|F8VUA7_HUMAN",4076,"Q9BZF1","OSBL8_HUMAN","Oxysterol-binding protein-related protein 8","RP-8;SBP-related protein 8","OSBPL8"]
["19.3587","19.3527","19.3165","18.2678",{"$nulls":3},"lipid catabolic process","N-acylphosphatidylethanolamine-specific phospholipase D activity;phospholipase D activity","endoplasmic reticulum membrane;extracellular exosome;integral component of membrane","Ether lipid metabolism;Glycerophospholipid metabolism;Metabolic pathways",null,null,4,4,4,"10.4","10.4","10.4","54.705","0.00026385","7.4975",84391000,8,"0.403452",1,"0.563559","1.07469","sp|Q8IV08|PLD3_HUMAN;tr|M0QZI4|M0QZI4_HUMAN;tr|M0R1F7|M0R1F7_HUMAN;tr|M0R2W7|M0R2W7_HUMAN;tr|E2QRG1|E2QRG1_HUMAN","sp|Q8IV08|PLD3_HUMAN;tr|M0QZI4|M0QZI4_HUMAN;tr|M0R1F7|M0R1F7_HUMAN",3108,"Q8IV08","PLD3_HUMAN","Phospholipase D3","LD 3","PLD3"]
[1,"17.5341",1,"16.4081",{"$nulls":9},1,1,1,1,1,1,"82.883","0.0067074","2.531",13723000,1,"0.0155659",1,"0.562995","0.0498212","tr|A0A087WSY3|A0A087WSY3_HUMAN;sp|Q3MJ40|C144B_HUMAN;tr|A6NG92|A6NG92_HUMAN;tr|C9JT67|C9JT67_HUMAN;sp|A2RUR9|C144A_HUMAN","tr|A0A087WSY3|A0A087WSY3_HUMAN;sp|Q3MJ40|C144B_HUMAN;tr|A6NG92|A6NG92_HUMAN;tr|C9JT67|C9JT67_HUMAN;sp|A2RUR9|C144A_HUMAN",159,"A0A087WSY3","A0A087WSY3_HUMAN",null,null,"CCDC144A"]
["24.1108","24.0488","24.2641","22.7703",{"$nulls":3},"post-chaperonin tubulin folding pathway;tubulin complex assembly","beta-tubulin binding","cytoplasm;microtubule;microtubule cytoskeleton;nucleolus",{"$nulls":3},7,7,7,"58.3","58.3","58.3","10.08",0,"21.222",1085300000,42,"0.275571",1,"0.562643","0.752653","tr|E5RIW3|E5RIW3_HUMAN;sp|O75347|TBCA_HUMAN;tr|E5RJD8|E5RJD8_HUMAN;tr|E5RHG6|E5RHG6_HUMAN;tr|E5RIX8|E5RIX8_HUMAN","tr|E5RIW3|E5RIW3_HUMAN;sp|O75347|TBCA_HUMAN;tr|E5RJD8|E5RJD8_HUMAN;tr|E5RHG6|E5RHG6_HUMAN",547,"E5RIW3","E5RIW3_HUMAN","Tubulin-specific chaperone A {ECO:0000256|RuleBase:RU364030}",null,"TBCA"]
["18.4477","19.07","18.1675","18.2252",{"$nulls":4},"GTPase activator activity;metal ion binding",{"$nulls":4},4,4,4,"11.8","11.8","11.8","46.382","0.00026364","7.4737",38507000,5,"0.670298",1,"0.56254","1.8001","tr|A0A087WV97|A0A087WV97_HUMAN;sp|Q8WU79|SMAP2_HUMAN;tr|X6RCC3|X6RCC3_HUMAN","tr|A0A087WV97|A0A087WV97_HUMAN;sp|Q8WU79|SMAP2_HUMAN;tr|X6RCC3|X6RCC3_HUMAN",3413,"A0A087WV97","A0A087WV97_HUMAN",null,null,"SMAP2"]
["20.7337","21.7668","20.6489","20.7282",{"$nulls":3},"interleukin-12-mediated signaling pathway;negative regulation of cyclic-nucleotide phosphodiesterase activity;protein maturation by protein folding;protein targeting to mitochondrion;regulation of protein kinase A signaling;xenobiotic metabolic process","aryl hydrocarbon receptor binding;GAF domain binding;signal transducer activity;transcription coactivator activity;transcription factor binding;unfolded protein binding","aryl hydrocarbon receptor complex;cytoplasm;cytosol;membrane;nucleoplasm","Cushing syndrome",null,null,8,8,8,"31.2","31.2","31.2","37.636",0,"31.562",326240000,33,"0.40723",1,"0.561727","1.08433","sp|O00170|AIP_HUMAN;tr|E9PMH2|E9PMH2_HUMAN;tr|V9GYQ3|V9GYQ3_HUMAN","sp|O00170|AIP_HUMAN;tr|E9PMH2|E9PMH2_HUMAN",194,"O00170","AIP_HUMAN","AH receptor-interacting protein","IP","AIP"]
["16.0608","15.8091","16.3275","14.4203",{"$nulls":4},"GTPase activator activity;metal ion binding",{"$nulls":4},3,3,3,"5.7","5.7","5.7","88.02","0.0002586","7.1044",21258000,6,"0.208529",1,"0.561085","0.583331","tr|A0A087X1H5|A0A087X1H5_HUMAN;sp|Q15057|ACAP2_HUMAN;tr|C9J8L1|C9J8L1_HUMAN;tr|H7C3Q8|H7C3Q8_HUMAN","tr|A0A087X1H5|A0A087X1H5_HUMAN;sp|Q15057|ACAP2_HUMAN",2442,"A0A087X1H5","A0A087X1H5_HUMAN",null,null,"ACAP2"]
[1,"13.6766",1,"12.5571",{"$nulls":3},"cell differentiation;cell division;cell proliferation;chromosome segregation;DNA biosynthetic process;kidney development;kinetochore assembly;metaphase plate congression;mitotic cell cycle;mitotic spindle assembly checkpoint;muscle organ development;negative regulation of transcription, DNA-templated;protein transport;regulation of cell cycle;regulation of G2/M transition of mitotic cell cycle;regulation of striated muscle tissue development;response to drug;sister chromatid cohesion;ventricular system development","chromatin binding;dynein complex binding;protein C-terminus binding;protein homodimerization activity;transcription factor binding","axoneme;centrosome;chromosome, centromeric region;ciliary basal body;ciliary transition fiber;condensed chromosome outer kinetochore;cytoplasm;cytosol;kinetochore;midbody;nuclear envelope;nuclear matrix;nucleoplasm;nucleus;perinuclear region of cytoplasm;pronucleus;spindle;spindle pole",{"$nulls":3},1,1,1,"0.3","0.3","0.3","367.76","0.0058023","2.6594",6189500,2,"0.0204959",1,"0.559745","0.0652607","sp|P49454|CENPF_HUMAN","sp|P49454|CENPF_HUMAN",1576,"P49454","CENPF_HUMAN","Centromere protein F","ENP-F","CENPF"]
[1,"18.5277",1,"17.4099",{"$nulls":4},"nucleoside-triphosphate diphosphatase activity;O-methyltransferase activity","cytosol",{"$nulls":3},5,5,5,"14.7","14.7","14.7","68.856",0,"21.176",43511000,10,"0.0145291",1,"0.558898","0.0465545","sp|O95671|ASML_HUMAN","sp|O95671|ASML_HUMAN",751,"O95671","ASML_HUMAN","N-acetylserotonin O-methyltransferase-like protein","SMTL","ASMTL"]
[1,"15.9977",1,"14.8877",{"$nulls":3},"negative regulation of transcription, DNA-templated;regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding;methyl-CpG binding","cytosol;nucleoplasm;nucleus",{"$nulls":3},8,8,8,"12.4","12.4","12.4","118.87",0,"18.201",101760000,23,"0.0169912",1,"0.55496","0.054301","sp|Q9ULJ3|ZBT21_HUMAN","sp|Q9ULJ3|ZBT21_HUMAN",4818,"Q9ULJ3","ZBT21_HUMAN","Zinc finger and BTB domain-containing protein 21",null,"ZBTB21"]
["23.3339","23.6476","23.3793","22.495",{"$nulls":3},"cell differentiation;cilium assembly;cytokinesis;positive regulation of non-motile cilium assembly;protein heterooligomerization;regulation of embryonic cell shape;spermatogenesis","cadherin binding;GTP binding;identical protein binding;structural molecule activity","axoneme;cleavage furrow;condensed chromosome kinetochore;cytosol;extracellular exosome;midbody;non-motile cilium;nucleus;septin complex;sperm annulus;spindle;stress fiber",{"$nulls":3},11,11,11,"33.9","33.9","33.9","50.679",0,"183.54",2031800000,92,"0.444501",1,"0.553589","1.18001","sp|Q16181|SEPT7_HUMAN;tr|E7ES33|E7ES33_HUMAN;tr|E7EPK1|E7EPK1_HUMAN;tr|H0Y3Y4|H0Y3Y4_HUMAN;tr|G3V1Q4|G3V1Q4_HUMAN;tr|Q5JXL7|Q5JXL7_HUMAN;sp|Q6ZU15|SEP14_HUMAN","sp|Q16181|SEPT7_HUMAN;tr|E7ES33|E7ES33_HUMAN;tr|E7EPK1|E7EPK1_HUMAN;tr|H0Y3Y4|H0Y3Y4_HUMAN;tr|G3V1Q4|G3V1Q4_HUMAN",2536,"Q16181","SEPT7_HUMAN","Septin-7",null,"SEPT7"]
["14.8062",1,1,"13.7012",{"$nulls":4},"DNA binding","cytosol;nucleoplasm",{"$nulls":3},10,10,10,15,15,15,"99.328",0,"23.002",335400000,42,"0.0184604",1,"0.552525","0.0589049","tr|C9JA69|C9JA69_HUMAN;sp|Q8WY36|BBX_HUMAN;tr|C9J8D0|C9J8D0_HUMAN;tr|C9JYU6|C9JYU6_HUMAN;tr|C9JZA0|C9JZA0_HUMAN;tr|H7C1Q0|H7C1Q0_HUMAN","tr|C9JA69|C9JA69_HUMAN;sp|Q8WY36|BBX_HUMAN",3468,"C9JA69","C9JA69_HUMAN",null,null,"BBX"]
["23.3336","23.345","23.1955","22.3839",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","metal ion binding;RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;nucleus","Ribosome",null,null,5,5,5,"45.7","45.7","45.7","10.275",0,"110.15",4715500000,251,"0.510925",1,"0.549628","1.35425","sp|P61513|RL37A_HUMAN;tr|G5E9R3|G5E9R3_HUMAN;tr|C9J4Z3|C9J4Z3_HUMAN;tr|Q6P4E4|Q6P4E4_HUMAN;tr|E9PEL3|E9PEL3_HUMAN;tr|M0R0A1|M0R0A1_HUMAN;tr|M0R2L6|M0R2L6_HUMAN;sp|A6NKH3|RL37L_HUMAN","sp|P61513|RL37A_HUMAN;tr|G5E9R3|G5E9R3_HUMAN;tr|C9J4Z3|C9J4Z3_HUMAN;tr|Q6P4E4|Q6P4E4_HUMAN;tr|E9PEL3|E9PEL3_HUMAN;tr|M0R0A1|M0R0A1_HUMAN;tr|M0R2L6|M0R2L6_HUMAN",1848,"P61513","RL37A_HUMAN","60S ribosomal protein L37a",null,"RPL37A"]
["16.1144","16.0991","15.5026","15.6133",{"$nulls":3},"cell division;kinetochore assembly;mitotic sister chromatid cohesion","DNA binding;metal ion binding","cytoplasm;cytosol;nuclear chromatin;nucleoplasm;nucleus",{"$nulls":3},18,18,18,"21.8","21.8","21.8","155.34",0,"55.306",575670000,93,"1.99053",1,"0.548827","9.8156","sp|Q7Z3K3|POGZ_HUMAN;tr|M0R2X2|M0R2X2_HUMAN;tr|H7C238|H7C238_HUMAN;tr|A6PW30|A6PW30_HUMAN;tr|E9PJY9|E9PJY9_HUMAN;tr|E9PIR8|E9PIR8_HUMAN;tr|H0YCT3|H0YCT3_HUMAN","sp|Q7Z3K3|POGZ_HUMAN",2994,"Q7Z3K3","POGZ_HUMAN","Pogo transposable element with ZNF domain",null,"POGZ"]
[1,"18.9831",1,"17.8856",{"$nulls":3},"negative regulation of defense response to virus;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interferon-beta production;negative regulation of NF-kappaB import into nucleus;N-terminal protein myristoylation;peptidyl-threonine dephosphorylation;protein dephosphorylation","magnesium ion binding;manganese ion binding;protein serine/threonine phosphatase activity","cytosol;membrane;nucleolus","MAPK signaling pathway",null,null,4,2,2,"9.6",5,5,"52.642",0,"8.7019",36400000,5,"0.0138759",1,"0.548774","0.0444925","sp|O75688|PPM1B_HUMAN;tr|B8ZZF0|B8ZZF0_HUMAN;tr|C9JIR6|C9JIR6_HUMAN","sp|O75688|PPM1B_HUMAN;tr|B8ZZF0|B8ZZF0_HUMAN;tr|C9JIR6|C9JIR6_HUMAN",602,"O75688","PPM1B_HUMAN","Protein phosphatase 1B",null,"PPM1B"]
["13.7423","15.0443","14.5226","13.1688",{"$nulls":3},"blood coagulation;small GTPase mediated signal transduction","guanyl-nucleotide exchange factor activity","cytosol;perinuclear region of cytoplasm",{"$nulls":3},4,3,3,"2.2","1.9","1.9","229.56","0.00026532","7.6166",16515000,8,"0.20844",1,"0.547612","0.583103","sp|Q96HP0|DOCK6_HUMAN;tr|K7EP20|K7EP20_HUMAN;tr|K7ESB7|K7ESB7_HUMAN","sp|Q96HP0|DOCK6_HUMAN",3719,"Q96HP0","DOCK6_HUMAN","Dedicator of cytokinesis protein 6",null,"DOCK6"]
["21.2283","20.1029","21.5422","18.698",{"$nulls":4},"RNA binding",{"$nulls":4},4,4,4,"17.9","17.9","17.9","34.812",0,"12.789",185640000,13,"0.121791",1,"0.545477","0.356666","tr|B4DHE8|B4DHE8_HUMAN;sp|Q96DH6|MSI2H_HUMAN;tr|J3KTC1|J3KTC1_HUMAN;tr|J3QKT5|J3QKT5_HUMAN;tr|B4DM51|B4DM51_HUMAN","tr|B4DHE8|B4DHE8_HUMAN;sp|Q96DH6|MSI2H_HUMAN;tr|J3KTC1|J3KTC1_HUMAN;tr|J3QKT5|J3QKT5_HUMAN;tr|B4DM51|B4DM51_HUMAN",3653,"B4DHE8","B4DHE8_HUMAN",null,null,"MSI2"]
["17.364","16.6233","17.4103","15.4875",{"$nulls":3},"actin filament organization;female gamete generation","actin binding;Rho GTPase binding","endoplasmic reticulum;intracellular membrane-bounded organelle;nucleolus",{"$nulls":3},8,8,8,"8.8","8.8","8.8","124.85",0,"16.712",72051000,9,"0.187218",1,"0.544734","0.528733","tr|A6NML8|A6NML8_HUMAN;tr|C9J6U3|C9J6U3_HUMAN;tr|K4DI95|K4DI95_HUMAN;sp|O60879|DIAP2_HUMAN","tr|A6NML8|A6NML8_HUMAN;tr|C9J6U3|C9J6U3_HUMAN;tr|K4DI95|K4DI95_HUMAN;sp|O60879|DIAP2_HUMAN",5165,"A6NML8","A6NML8_HUMAN"]
["18.3759","19.7719","18.6548","18.4052",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;rRNA import into mitochondrion;translation","5S rRNA binding;structural constituent of ribosome","extracellular space;mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome;mitochondrion","Ribosome",null,null,4,4,4,"22.2","22.2","22.2","20.576","0.00046849","4.952",23261000,8,"0.281315",1,"0.543909","0.767064","sp|Q9H0U6|RM18_HUMAN","sp|Q9H0U6|RM18_HUMAN",4146,"Q9H0U6","RM18_HUMAN","39S ribosomal protein L18, mitochondrial","18mt;RP-L18","MRPL18"]
["19.1833","19.4717","19.0517","18.5158",{"$nulls":3},"RNA processing","RNA binding","cytosol;intracellular ribonucleoprotein complex;nucleoplasm",{"$nulls":3},8,8,8,"19.1","19.1","19.1","66.898",0,"23.27",243720000,56,"0.665793",1,"0.543694","1.78683","sp|Q4G0J3|LARP7_HUMAN;tr|H0YA82|H0YA82_HUMAN;tr|D6RFF0|D6RFF0_HUMAN;tr|D6R9Z6|D6R9Z6_HUMAN","sp|Q4G0J3|LARP7_HUMAN;tr|H0YA82|H0YA82_HUMAN",2629,"Q4G0J3","LARP7_HUMAN","La-related protein 7",null,"LARP7"]
["20.0961","18.554","19.4237","18.1395",{"$nulls":3},"deadenylation-dependent decapping of nuclear-transcribed mRNA;deadenylation-independent decapping of nuclear-transcribed mRNA;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;protein localization to cytoplasmic stress granule;regulation of mRNA stability","enzyme activator activity;enzyme regulator activity;hydrolase activity;identical protein binding;kinesin binding;mRNA binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;membrane;nucleus;P-body","RNA degradation",null,null,6,6,6,"19.4","19.4","19.4","63.309",0,"11.07",129690000,18,"0.192242",1,"0.543479","0.541654","sp|Q9NPI6|DCP1A_HUMAN;tr|A0A087WT55|A0A087WT55_HUMAN","sp|Q9NPI6|DCP1A_HUMAN",4371,"Q9NPI6","DCP1A_HUMAN","mRNA-decapping enzyme 1A",null,"DCP1A"]
["19.4163","20.3966","19.5426","19.1887",{"$nulls":9},7,7,7,"17.1","17.1","17.1","69.8",0,"18.84",198190000,21,"0.38893",1,"0.540777","1.03777","tr|B8ZZW5|B8ZZW5_HUMAN;sp|Q8NBF6|AVL9_HUMAN;tr|H7C0I1|H7C0I1_HUMAN","tr|B8ZZW5|B8ZZW5_HUMAN;sp|Q8NBF6|AVL9_HUMAN;tr|H7C0I1|H7C0I1_HUMAN",3281,"B8ZZW5","B8ZZW5_HUMAN",null,null,"AVL9"]
["20.2915","20.5251","20.8562","18.8801",{"$nulls":3},"mitochondrial respiratory chain complex I assembly","oxidoreductase activity","integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion",{"$nulls":3},6,6,6,"17.3","17.3","17.3","53.811",0,"17.366",282670000,34,"0.192729",1,"0.540148","0.542905","sp|Q96CU9|FXRD1_HUMAN;tr|E9PP78|E9PP78_HUMAN","sp|Q96CU9|FXRD1_HUMAN",3642,"Q96CU9","FXRD1_HUMAN","FAD-dependent oxidoreductase domain-containing protein 1 {ECO:0000312|HGNC:HGNC:26927}",null,"FOXRED1"]
["19.6655","21.0342","19.8323","19.7874",{"$nulls":3},"transmembrane transport","transporter activity","integral component of membrane",{"$nulls":3},2,2,2,"7.4","7.4","7.4","34.952","0.00026392","7.5037",124600000,13,"0.2899",1,"0.539991","0.788595","tr|E9PRM7|E9PRM7_HUMAN;tr|A0A0J9YWM3|A0A0J9YWM3_HUMAN;tr|A0A024RCG2|A0A024RCG2_HUMAN;sp|Q96BI1|S22AI_HUMAN","tr|E9PRM7|E9PRM7_HUMAN;tr|A0A0J9YWM3|A0A0J9YWM3_HUMAN;tr|A0A024RCG2|A0A024RCG2_HUMAN;sp|Q96BI1|S22AI_HUMAN",3611,"E9PRM7","E9PRM7_HUMAN",null,null,"SLC22A18"]
["19.8696","18.8085","20.0695","17.5297",{"$nulls":3},"rRNA base methylation","RNA binding;RNA methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity","nucleolus;nucleus",{"$nulls":3},9,9,9,"27.3","27.3","27.3","46.691",0,"22.983",278310000,39,"0.13495",1,"0.539443","0.391965","sp|Q96P11|NSUN5_HUMAN;sp|Q63ZY6|NSN5C_HUMAN;sp|Q3KNT7|NSN5B_HUMAN","sp|Q96P11|NSUN5_HUMAN",3780,"Q96P11","NSUN5_HUMAN","Probable 28S rRNA (cytosine-C(5))-methyltransferase",null,"NSUN5"]
["20.1423","21.0285","20.8034","19.2897",{"$nulls":3},"RNA phosphodiester bond hydrolysis, endonucleolytic","endoribonuclease activity;single-stranded RNA binding;zinc ion binding","mitochondrial matrix",{"$nulls":3},7,7,7,"25.7","25.7","25.7","32.805",0,"19.861",152260000,19,"0.22075",1,"0.538855","0.614424","sp|Q53H82|LACB2_HUMAN","sp|Q53H82|LACB2_HUMAN",2657,"Q53H82","LACB2_HUMAN","Endoribonuclease LACTB2 {ECO:0000303|PubMed:26826708}",null,"LACTB2"]
["19.8482","19.6592","20.3992","18.033",{"$nulls":3},"DNA replication","DNA binding;DNA-directed DNA polymerase activity","nucleoplasm",{"$nulls":3},7,7,7,"21.1","21.1","21.1","49.612",0,"30.476",301200000,49,"0.158035",1,"0.537601","0.452966","tr|F8W8R3|F8W8R3_HUMAN;sp|P49005|DPOD2_HUMAN;tr|A0A087WWF6|A0A087WWF6_HUMAN;tr|C9IZD2|C9IZD2_HUMAN;tr|C9J8Z7|C9J8Z7_HUMAN;tr|C9JLE1|C9JLE1_HUMAN;tr|C9JHC7|C9JHC7_HUMAN;tr|H7C1B3|H7C1B3_HUMAN","tr|F8W8R3|F8W8R3_HUMAN;sp|P49005|DPOD2_HUMAN;tr|A0A087WWF6|A0A087WWF6_HUMAN;tr|C9IZD2|C9IZD2_HUMAN;tr|C9J8Z7|C9J8Z7_HUMAN;tr|C9JLE1|C9JLE1_HUMAN;tr|C9JHC7|C9JHC7_HUMAN",1556,"F8W8R3","F8W8R3_HUMAN",null,null,"POLD2"]
["20.0015","20.4504","19.5085","19.8683",{"$nulls":9},1,1,1,"17.4","17.4","17.4","13.659","0.0037121","3.0477",52231000,9,"0.693419",1,"0.537576","1.86892","tr|Q5JZ02|Q5JZ02_HUMAN;sp|Q96S44|PRPK_HUMAN","tr|Q5JZ02|Q5JZ02_HUMAN;sp|Q96S44|PRPK_HUMAN",3811,"Q5JZ02","Q5JZ02_HUMAN",null,null,"TP53RK"]
["24.3093","24.2963","24.5851","22.9454",{"$nulls":3},"camera-type eye development;cellular protein metabolic process;in utero embryonic development;post-translational protein modification","calcium ion binding","endoplasmic reticulum;endoplasmic reticulum lumen",{"$nulls":3},14,14,14,"52.9","52.9","52.9","38.89",0,"323.31",2673000000,96,"0.237034",1,"0.537561","0.655663","sp|Q15293|RCN1_HUMAN;tr|E9PP27|E9PP27_HUMAN","sp|Q15293|RCN1_HUMAN",2470,"Q15293","RCN1_HUMAN","Reticulocalbin-1",null,"RCN1"]
[1,"18.447",1,"17.3725",{"$nulls":3},"carbohydrate metabolic process;O-glycan processing;protein O-linked glycosylation","carbohydrate binding;metal ion binding;polypeptide N-acetylgalactosaminyltransferase activity","extracellular exosome;Golgi membrane;integral component of membrane;membrane","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,5,5,5,"8.7","8.7","8.7","75.388",0,"9.6172",32841000,13,"0.0140081",1,"0.53726","0.0449101","sp|Q86SF2|GALT7_HUMAN;tr|H0YAK0|H0YAK0_HUMAN;tr|H0YAH3|H0YAH3_HUMAN;tr|E9PBY3|E9PBY3_HUMAN","sp|Q86SF2|GALT7_HUMAN;tr|H0YAK0|H0YAK0_HUMAN;tr|H0YAH3|H0YAH3_HUMAN",3027,"Q86SF2","GALT7_HUMAN","N-acetylgalactosaminyltransferase 7",null,"GALNT7"]
["21.1291","21.4606","21.4925","20.0228",{"$nulls":3},"activation of innate immune response;cellular response to exogenous dsRNA;defense response to bacterium;defense response to virus;innate immune response;negative regulation of type I interferon production;negative regulation of viral genome replication;positive regulation of chemokine (C-C motif) ligand 5 production;positive regulation of defense response to virus by host;positive regulation of DNA binding transcription factor activity;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-alpha secretion;positive regulation of interferon-beta production;positive regulation of interferon-beta secretion;positive regulation of interleukin-6 secretion;positive regulation of interleukin-8 production;positive regulation of IP-10 production;positive regulation of protein import into nucleus, translocation;positive regulation of protein phosphorylation;positive regulation of response to cytokine stimulus;positive regulation of transcription factor import into nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of tumor necrosis factor production;positive regulation of tumor necrosis factor secretion;positive regulation of type I interferon-mediated signaling pathway;protein deubiquitination;regulation of peroxisome organization;signal transduction;viral process","CARD domain binding;protein kinase binding;signal transducer activity","integral component of membrane;mitochondrial membrane;mitochondrial outer membrane;mitochondrion;peroxisomal membrane","Cytosolic DNA-sensing pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Influenza A;Measles;NOD-like receptor signaling pathway;RIG-I-like receptor signaling pathway",null,null,10,10,10,"41.9","41.9","41.9","56.527",0,"53.24",350600000,55,"0.259844",1,"0.537201","0.713146","sp|Q7Z434|MAVS_HUMAN","sp|Q7Z434|MAVS_HUMAN",2998,"Q7Z434","MAVS_HUMAN","Mitochondrial antiviral-signaling protein","AVS","MAVS"]
["22.9538","24.4639","22.8932","23.4507",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},5,5,5,"42.1","42.1","42.1","12.656",0,"30.361",722450000,31,"0.241562",1,"0.536915","0.667096","tr|E5RI99|E5RI99_HUMAN;sp|P62888|RL30_HUMAN;tr|E5RJH3|E5RJH3_HUMAN;tr|A0A0C4DH44|A0A0C4DH44_HUMAN;tr|A0A0B4J213|A0A0B4J213_HUMAN","tr|E5RI99|E5RI99_HUMAN;sp|P62888|RL30_HUMAN",1922,"E5RI99","E5RI99_HUMAN",null,null,"RPL30"]
["25.3542","24.8902","25.1176","24.0532",{"$nulls":3},"apoptotic DNA fragmentation;cell chemotaxis;cellular response to lipopolysaccharide;chromatin organization;defense response to Gram-negative bacterium;defense response to Gram-positive bacterium;DNA geometric change;DNA ligation involved in DNA repair;DNA topological change;inflammatory response to antigenic stimulus;innate immune response;male gonad development;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of transcription, DNA-templated;nucleosome assembly;positive regulation of DNA binding;positive regulation of endothelial cell proliferation;positive regulation of erythrocyte differentiation;positive regulation of innate immune response;positive regulation of interferon-beta production;positive regulation of megakaryocyte differentiation;positive regulation of nuclease activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of neurogenesis;regulation of stem cell proliferation;regulation of transcription from RNA polymerase II promoter;response to drug;response to lipopolysaccharide;response to steroid hormone;spermatid nucleus differentiation;transcription, DNA-templated;V(D)J recombination","chemoattractant activity;damaged DNA binding;DNA binding;DNA binding transcription factor activity;DNA binding, bending;double-stranded DNA binding;drug binding;enhancer sequence-specific DNA binding;four-way junction DNA binding;non-sequence-specific DNA binding, bending;protein domain specific binding;RAGE receptor binding;RNA binding;single-stranded DNA binding;supercoiled DNA binding;transcription factor binding;transcription regulatory region DNA binding","cell;condensed chromosome;cytoplasm;extracellular space;nuclear chromatin;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex",{"$nulls":3},7,6,6,"28.2","22.5","22.5","24.033",0,"51.572",1892500000,87,"0.344106",1,"0.536772","0.924591","sp|P26583|HMGB2_HUMAN;tr|D6R9A6|D6R9A6_HUMAN","sp|P26583|HMGB2_HUMAN;tr|D6R9A6|D6R9A6_HUMAN",1241,"P26583","HMGB2_HUMAN","High mobility group protein B2",null,"HMGB2"]
["16.0817","19.4653","17.3927","17.0861",{"$nulls":3},"intracellular protein transport","Ran GTPase binding","nucleus",{"$nulls":3},7,4,4,"11.1","7.4","7.4","86.54",0,"14.57",63507000,11,"0.106257",1,"0.534125","0.314428","tr|A0A075B780|A0A075B780_HUMAN;sp|O14787|TNPO2_HUMAN;tr|K7ENW1|K7ENW1_HUMAN;tr|K7ESC1|K7ESC1_HUMAN;tr|K7EMA3|K7EMA3_HUMAN","tr|A0A075B780|A0A075B780_HUMAN;sp|O14787|TNPO2_HUMAN",287,"A0A075B780","A0A075B780_HUMAN",null,null,"TNPO2"]
["23.8396","24.232","23.7502","23.2535",{"$nulls":3},"C21-steroid hormone biosynthetic process;carbohydrate metabolic process;cellular response to methylglyoxal;cellular response to peptide;daunorubicin metabolic process;doxorubicin metabolic process;fructose biosynthetic process;inner medullary collecting duct development;maternal process involved in female pregnancy;naphthalene metabolic process;negative regulation of apoptotic process;norepinephrine metabolic process;positive regulation of JAK-STAT cascade;positive regulation of smooth muscle cell proliferation;regulation of urine volume;renal water homeostasis;response to stress;response to thyroid hormone;response to water deprivation;sorbitol biosynthetic process;stress-activated protein kinase signaling cascade;tissue homeostasis","alditol:NADP+ 1-oxidoreductase activity;aldo-keto reductase (NADP) activity;electron transfer activity;glyceraldehyde oxidoreductase activity","cytosol;extracellular exosome;extracellular space;mast cell granule;nucleoplasm;paranodal junction;perinuclear region of cytoplasm;plasma membrane bounded cell projection cytoplasm;Schmidt-Lanterman incisure;Schwann cell microvillus","Folate biosynthesis;Fructose and mannose metabolism;Galactose metabolism;Glycerolipid metabolism;Metabolic pathways;Pentose and glucuronate interconversions",null,null,13,13,12,"52.8","52.8","50.3","35.853",0,"170.79",2203500000,104,"0.63143",1,"0.533964","1.68701","sp|P15121|ALDR_HUMAN;tr|E9PCX2|E9PCX2_HUMAN;tr|E9PEF9|E9PEF9_HUMAN","sp|P15121|ALDR_HUMAN;tr|E9PCX2|E9PCX2_HUMAN",1057,"P15121","ALDR_HUMAN","Aldose reductase","R","AKR1B1"]
["17.4784","19.7108","19.0171","17.1053",{"$nulls":3},"antigen processing and presentation;endosome to melanosome transport;melanosome assembly;mitochondrion organization;phagosome maturation;protein localization to membrane;vesicle-mediated transport","AP-1 adaptor complex binding;AP-3 adaptor complex binding;BLOC-2 complex binding;GTP binding;GTPase activity;GTP-dependent protein binding","cytosol;early endosome;endoplasmic reticulum;ER-mitochondrion membrane contact site;melanosome;melanosome membrane;membrane;mitochondrial outer membrane;mitochondrion;phagocytic vesicle;phagocytic vesicle membrane;trans-Golgi network",{"$nulls":3},5,5,5,"35.1","35.1","35.1","24.997",0,"18.416",72285000,15,"0.124125",1,"0.533383","0.362959","sp|Q13637|RAB32_HUMAN","sp|Q13637|RAB32_HUMAN",2297,"Q13637","RAB32_HUMAN","Ras-related protein Rab-32",null,"RAB32"]
[1,"15.4705",1,"14.4049",{"$nulls":3},"ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitin-specific protease activity","cytosol;nucleoplasm",{"$nulls":3},1,1,1,"1.5","1.5","1.5","78.15","0.0023202","3.3567",9074400,3,"0.0169012",1,"0.532763","0.0540183","tr|F8W6N3|F8W6N3_HUMAN;sp|Q92560|BAP1_HUMAN","tr|F8W6N3|F8W6N3_HUMAN;sp|Q92560|BAP1_HUMAN",3495,"F8W6N3","F8W6N3_HUMAN","Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU361215}",null,"BAP1"]
["18.6514","18.819","18.7879","17.6195",{"$nulls":3},"carbohydrate metabolic process;fibroblast growth factor receptor signaling pathway;O-glycan processing;protein O-linked glycosylation via serine;protein O-linked glycosylation via threonine","calcium ion binding;carbohydrate binding;manganese ion binding;polypeptide N-acetylgalactosaminyltransferase activity","extracellular exosome;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;integral component of membrane;membrane;perinuclear region of cytoplasm","Metabolic pathways;Mucin type O-glycan biosynthesis",null,null,17,17,17,"32.1","32.1","32.1","72.609",0,"131.89",1719900000,128,"0.33459",1,"0.531554","0.900677","sp|Q14435|GALT3_HUMAN;tr|C9J2C3|C9J2C3_HUMAN;tr|E7EUL0|E7EUL0_HUMAN;tr|C9J388|C9J388_HUMAN;tr|S4R3S5|S4R3S5_HUMAN;sp|Q8NCL4|GALT6_HUMAN;tr|C9JXX2|C9JXX2_HUMAN;tr|H7BZS4|H7BZS4_HUMAN","sp|Q14435|GALT3_HUMAN;tr|C9J2C3|C9J2C3_HUMAN",2361,"Q14435","GALT3_HUMAN","Polypeptide N-acetylgalactosaminyltransferase 3",null,"GALNT3"]
["18.7494","16.8147","18.2815","16.2212",{"$nulls":5},"cytosol;extracellular exosome;Golgi apparatus;nucleoplasm",{"$nulls":3},3,3,3,"13.4","13.4","13.4","39.933","0.0002686","7.9397",23166000,8,"0.128806",1,"0.530688","0.375536","sp|Q96A49|SYAP1_HUMAN","sp|Q96A49|SYAP1_HUMAN",3593,"Q96A49","SYAP1_HUMAN","Synapse-associated protein 1",null,"SYAP1"]
["17.6805","17.2534","18.0872","15.7854",{"$nulls":3},"endocytosis;membrane organization;positive regulation of Notch signaling pathway;protein autophosphorylation;protein phosphorylation;protein stabilization;regulation of clathrin-dependent endocytosis;regulation of protein localization","AP-2 adaptor complex binding;ATP binding;Notch binding;protein serine/threonine kinase activity","cell leading edge;clathrin-coated pit;clathrin-coated vesicle;cytoplasm;cytosol;extrinsic component of plasma membrane;terminal bouton",{"$nulls":3},7,7,7,"13.8","13.8","13.8","103.88",0,"10.745",77168000,14,"0.158187",1,"0.530676","0.453366","sp|Q2M2I8|AAK1_HUMAN;tr|E9PG46|E9PG46_HUMAN;tr|A0A096LP60|A0A096LP60_HUMAN;tr|A0A096LNZ0|A0A096LNZ0_HUMAN;tr|A0A096LP25|A0A096LP25_HUMAN","sp|Q2M2I8|AAK1_HUMAN;tr|E9PG46|E9PG46_HUMAN",2593,"Q2M2I8","AAK1_HUMAN","AP2-associated protein kinase 1",null,"AAK1"]
["19.0246","19.725","19.7311","17.9591",{"$nulls":3},"cellular amino acid metabolic process;selenium compound metabolic process","selenocysteine lyase activity;transferase activity","cytosol","Metabolic pathways;Selenocompound metabolism",null,null,6,6,6,"20.4","20.4","20.4","48.148",0,"16.161",135560000,14,"0.197851",1,"0.529748","0.556042","sp|Q96I15|SCLY_HUMAN;tr|A0A0A0MQU4|A0A0A0MQU4_HUMAN;tr|H7C3V9|H7C3V9_HUMAN;tr|H7C277|H7C277_HUMAN;tr|C9JNL5|C9JNL5_HUMAN;tr|H7C1N7|H7C1N7_HUMAN;tr|H7C1S7|H7C1S7_HUMAN;tr|F8WCL3|F8WCL3_HUMAN;tr|F8WBU3|F8WBU3_HUMAN;tr|H7C2M1|H7C2M1_HUMAN;tr|H7C4A1|H7C4A1_HUMAN","sp|Q96I15|SCLY_HUMAN;tr|A0A0A0MQU4|A0A0A0MQU4_HUMAN;tr|H7C3V9|H7C3V9_HUMAN;tr|H7C277|H7C277_HUMAN;tr|C9JNL5|C9JNL5_HUMAN",3726,"Q96I15","SCLY_HUMAN","Selenocysteine lyase","SCL","SCLY"]
["20.9503","19.9431","20.2634","19.5715",{"$nulls":3},"protein folding in endoplasmic reticulum",null,"cytoplasm;endoplasmic reticulum;ER membrane protein complex;mitochondrion;nucleus",{"$nulls":3},6,6,6,"25.3","25.3","25.3","34.833",0,"23.393",227690000,30,"0.32085",1,"0.529241","0.866192","sp|Q15006|EMC2_HUMAN;tr|H0YAS9|H0YAS9_HUMAN","sp|Q15006|EMC2_HUMAN",2419,"Q15006","EMC2_HUMAN","ER membrane protein complex subunit 2",null,"EMC2"]
["19.3193","19.531","18.9273","18.8652",{"$nulls":9},3,3,3,26,26,26,"24.028","0.0015073","3.6185",62224000,8,"1.38879",1,"0.528871","4.79472","sp|Q96FF7|YS003_HUMAN;tr|A0A044PY82|A0A044PY82_HUMAN","sp|Q96FF7|YS003_HUMAN;tr|A0A044PY82|A0A044PY82_HUMAN",3683,"Q96FF7","MISP3_HUMAN","Uncharacterized protein MISP3 {ECO:0000305}",null,"MISP3"]
[1,"19.0554",1,"17.9986",{"$nulls":3},"cell cycle;nucleobase-containing compound metabolic process;positive regulation of Notch signaling pathway;pyrimidine nucleoside metabolic process;pyrimidine nucleotide biosynthetic process","methyl-CpG binding;RNA binding","methylosome;midbody",{"$nulls":3},2,2,2,"21.2","21.2","21.2","12.259","0.00068074","4.3749",6461400,3,"0.0132827",1,"0.528422","0.0426178","sp|P84090|ERH_HUMAN;tr|G3V279|G3V279_HUMAN","sp|P84090|ERH_HUMAN;tr|G3V279|G3V279_HUMAN",2009,"P84090","ERH_HUMAN","Enhancer of rudimentary homolog",null,"ERH"]
["20.2176","21.63","20.4437","20.3472",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome","Ribosome",null,null,4,4,4,"26.1","26.1","26.1","10.165",0,"11.863",415110000,32,"0.27308",1,"0.528333","0.7464","sp|Q9BQ48|RM34_HUMAN;tr|M0R226|M0R226_HUMAN","sp|Q9BQ48|RM34_HUMAN;tr|M0R226|M0R226_HUMAN",3908,"Q9BQ48","RM34_HUMAN","39S ribosomal protein L34, mitochondrial","34mt;RP-L34","MRPL34"]
["16.6979","16.4233","15.8703","16.1988",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated",null,"nuclear speck;Sin3-type complex",{"$nulls":3},4,4,4,"3.8","3.8","3.8","110.32",0,"8.6023",86713000,17,"0.875166",1,"0.526055","2.45714","sp|Q9H0E3|SP130_HUMAN;tr|H7BXF5|H7BXF5_HUMAN","sp|Q9H0E3|SP130_HUMAN;tr|H7BXF5|H7BXF5_HUMAN",4134,"Q9H0E3","SP130_HUMAN","Histone deacetylase complex subunit SAP130",null,"SAP130"]
["17.9793","17.4209","17.5604","16.7879",{"$nulls":3},"cellular response to hydroxyurea;cellular response to radiation;cellular response to UV;DNA recombination;DNA repair;positive regulation of protein ubiquitination;regulation of growth","protein dimerization activity","chromosome, telomeric region;cytoplasm;nucleoplasm;Smc5-Smc6 complex",{"$nulls":3},3,3,3,"11.8","11.8","11.8","34.308",0,"18.527",47305000,15,"0.414731",1,"0.525941","1.10349","sp|Q96MG7|MAGG1_HUMAN","sp|Q96MG7|MAGG1_HUMAN",3772,"Q96MG7","NSE3_HUMAN","Non-structural maintenance of chromosomes element 3 homolog","on-SMC element 3 homolog","NSMCE3"]
["13.4161","14.1511","13.6305","12.8858",{"$nulls":3},"G-protein coupled receptor signaling pathway;negative regulation of fat cell differentiation;positive regulation of apoptotic process;regulation of Rho protein signal transduction;regulation of small GTPase mediated signal transduction;transmembrane receptor protein tyrosine phosphatase signaling pathway","ATP binding;guanyl-nucleotide exchange factor activity;protein serine/threonine kinase activity;Rho guanyl-nucleotide exchange factor activity","cytosol",{"$nulls":3},19,19,16,"8.8","8.8","7.8","346.9",0,"50.547",187310000,34,"0.375771",1,"0.525454","1.00443","sp|O75962|TRIO_HUMAN;tr|E7EPJ7|E7EPJ7_HUMAN;tr|E7EWP2|E7EWP2_HUMAN;tr|F5H228|F5H228_HUMAN;tr|C9IZQ6|C9IZQ6_HUMAN;tr|H7C1X7|H7C1X7_HUMAN","sp|O75962|TRIO_HUMAN;tr|E7EPJ7|E7EPJ7_HUMAN;tr|E7EWP2|E7EWP2_HUMAN;tr|F5H228|F5H228_HUMAN",635,"O75962","TRIO_HUMAN","Triple functional domain protein",null,"TRIO"]
[1,"20.9024",1,"19.8523",{"$nulls":5},"integral component of membrane",{"$nulls":3},2,2,2,14,14,14,"11.896","0.0029203","3.2183",102100000,6,"0.0119215",1,"0.525066","0.0383068","tr|B1AH87|B1AH87_HUMAN;sp|P30536|TSPOA_HUMAN","tr|B1AH87|B1AH87_HUMAN;sp|P30536|TSPOA_HUMAN",1314,"B1AH87","B1AH87_HUMAN",null,null,"TSPO"]
[1,"20.8908","19.8411",1,{"$nulls":3},"tRNA processing",null,"EKC/KEOPS complex;nuclear body;nucleoplasm",{"$nulls":3},1,1,1,"16.1","16.1","16.1","14.804","0.00067476","4.2251",32102000,2,"0.0119244",1,"0.524881","0.0383158","sp|Q14657|LAGE3_HUMAN","sp|Q14657|LAGE3_HUMAN",2375,"Q14657","LAGE3_HUMAN","EKC/KEOPS complex subunit LAGE3",null,"LAGE3"]
["17.7791","21.1607","18.3225","19.5696",{"$nulls":3},"cell proliferation;ER to Golgi vesicle-mediated transport;Golgi to vacuole transport;intra-Golgi vesicle-mediated transport;membrane fusion;platelet degranulation;protein targeting to vacuole;regulation of protein localization to plasma membrane;retrograde transport, endosome to Golgi;vesicle docking involved in exocytosis;vesicle fusion with Golgi apparatus;vesicle-mediated transport","chloride channel inhibitor activity;SNAP receptor activity;SNARE binding","cytosol;early endosome membrane;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;extracellular region;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;late endosome membrane;lysosomal membrane;neuronal cell body;perinuclear region of cytoplasm;platelet alpha granule lumen;recycling endosome;recycling endosome membrane;SNARE complex;synaptic vesicle;vesicle","SNARE interactions in vesicular transport",null,null,8,8,7,"41.4","41.4","34.5","26.688",0,"31.504",441640000,27,"0.0976322",1,"0.523832","0.290674","sp|Q9UEU0|VTI1B_HUMAN;tr|H0YJL5|H0YJL5_HUMAN;tr|J3KMW2|J3KMW2_HUMAN;tr|G3V5I2|G3V5I2_HUMAN;tr|H0YJJ5|H0YJJ5_HUMAN","sp|Q9UEU0|VTI1B_HUMAN",4694,"Q9UEU0","VTI1B_HUMAN","Vesicle transport through interaction with t-SNAREs homolog 1B",null,"VTI1B"]
["17.6637","16.0378","16.935","15.721",{"$nulls":3},"establishment of centrosome localization;nuclear migration;positive regulation of stress fiber assembly;positive regulation of transcription from RNA polymerase II promoter;regulation of stress fiber assembly","actin binding;identical protein binding;protein domain specific binding;protein self-association","bleb;cytoplasm;cytoskeleton;cytosol;intercalated disc;membrane;nucleus",{"$nulls":3},8,8,8,"11.6","11.6","11.6","126.55",0,"8.8058",93349000,8,"0.181982",1,"0.522716","0.515235","sp|Q9Y613|FHOD1_HUMAN;tr|J3KTH7|J3KTH7_HUMAN","sp|Q9Y613|FHOD1_HUMAN",5071,"Q9Y613","FHOD1_HUMAN","FH1/FH2 domain-containing protein 1",null,"FHOD1"]
["17.5597","18.1965","17.5107","17.2021",{"$nulls":3},"cytokinesis;mitochondrial respiratory chain complex III assembly;oxidation-reduction process",null,"centrosome;midbody;mitochondrial inner membrane;mitochondrion;respiratory chain",{"$nulls":3},1,1,1,"3.2","3.2","3.2","42.456","0.0017123","3.5205",29137000,3,"0.55541",1,"0.521652","1.47426","sp|Q6DKK2|TTC19_HUMAN","sp|Q6DKK2|TTC19_HUMAN",2805,"Q6DKK2","TTC19_HUMAN","Tetratricopeptide repeat protein 19, mitochondrial","PR repeat protein 19","TTC19"]
["19.243","20.6143","19.0364","19.7791",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleolus;nucleus","Ribosome",null,null,7,7,7,"24.9","24.9","24.9","29.842",0,"15.694",702540000,48,"0.241944",1,"0.520914","0.66806","sp|P82914|RT15_HUMAN","sp|P82914|RT15_HUMAN",1995,"P82914","RT15_HUMAN","28S ribosomal protein S15, mitochondrial","15mt;RP-S15","MRPS15"]
[1,"20.6748",1,"19.6351",{"$nulls":4},"ATP binding",{"$nulls":4},1,1,1,"14.3","14.3","14.3","13.635","0.0015129","3.6613",13617000,4,"0.0119396",1,"0.519817","0.0383641","tr|A0A0D9SG71|A0A0D9SG71_HUMAN;tr|A0A0D9SEZ6|A0A0D9SEZ6_HUMAN;sp|P49459|UBE2A_HUMAN","tr|A0A0D9SG71|A0A0D9SG71_HUMAN;tr|A0A0D9SEZ6|A0A0D9SEZ6_HUMAN;sp|P49459|UBE2A_HUMAN",1578,"A0A0D9SG71","A0A0D9SG71_HUMAN",null,null,"UBE2A"]
["16.9971","17.5546","17.671","15.8411",{"$nulls":3},"protein homooligomerization;protein processing;proteolysis;regulation of fatty acid beta-oxidation","identical protein binding;protease binding;serine-type endopeptidase activity","membrane;peroxisome",{"$nulls":3},1,1,1,"3.5","3.5","3.5","59.308","0.0013141","3.8739",14010000,4,"0.192945",1,"0.519806","0.543459","sp|Q2T9J0|TYSD1_HUMAN","sp|Q2T9J0|TYSD1_HUMAN",2600,"Q2T9J0","TYSD1_HUMAN","Peroxisomal leader peptide-processing protease",null,"TYSND1"]
["17.3736","18.7512","16.6121","18.4763",{"$nulls":3},"cellular response to DNA damage stimulus;chromatin remodeling;covalent chromatin modification;negative regulation of DNA damage checkpoint;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;regulation of inflammatory response;regulation of phosphorylation of RNA polymerase II C-terminal domain;regulation of transcription involved in G1/S transition of mitotic cell cycle;transcription, DNA-templated;viral process","chromatin binding;lysine-acetylated histone binding;p53 binding;RNA polymerase II core binding","chromosome;condensed nuclear chromosome;cytosol;nucleoplasm;nucleus",{"$nulls":3},20,18,15,"17.8","16.4","14.2","152.22",0,"53.882",433170000,58,"0.15579",1,"0.518166","0.44708","sp|O60885|BRD4_HUMAN;tr|M0QZD9|M0QZD9_HUMAN;tr|M0R0H4|M0R0H4_HUMAN;tr|M0QYW0|M0QYW0_HUMAN","sp|O60885|BRD4_HUMAN;tr|M0QZD9|M0QZD9_HUMAN",513,"O60885","BRD4_HUMAN","Bromodomain-containing protein 4",null,"BRD4"]
["22.0037","21.7699","22.1388","20.5987",{"$nulls":3},"nuclear membrane organization",null,"endoplasmic reticulum;Golgi apparatus;integral component of membrane;nuclear inner membrane",{"$nulls":3},13,13,13,"42.8","42.8","42.8","44.875",0,"86.158",708500000,67,"0.240781",1,"0.518043","0.665124","sp|Q9BTV4|TMM43_HUMAN;tr|V9GY05|V9GY05_HUMAN","sp|Q9BTV4|TMM43_HUMAN",3972,"Q9BTV4","TMM43_HUMAN","Transmembrane protein 43",null,"TMEM43"]
["18.9707","18.229","18.3342","17.8305",{"$nulls":3},"intracellular protein transport;vesicle-mediated transport;viral process","protein transporter activity","AP-1 adaptor complex;endosome membrane;Golgi apparatus;Golgi membrane;Golgi-associated vesicle;membrane;transport vesicle","Human immunodeficiency virus 1 infection;Lysosome",null,null,4,4,4,"5.9","5.9","5.9","87.116",0,"11.444",101040000,9,"0.434614",1,"0.517558","1.15451","sp|O75843|AP1G2_HUMAN;tr|G3V532|G3V532_HUMAN;tr|G3V2V9|G3V2V9_HUMAN;tr|G3V3Z2|G3V3Z2_HUMAN","sp|O75843|AP1G2_HUMAN;tr|G3V532|G3V532_HUMAN",617,"O75843","AP1G2_HUMAN","AP-1 complex subunit gamma-like 2",null,"AP1G2"]
[1,"20.1238",1,"19.0888",{"$nulls":3},"cellular nitrogen compound metabolic process;glycine catabolic process;glycine decarboxylation via glycine cleavage system;protein lipoylation","aminomethyltransferase activity","glycine cleavage complex;mitochondrial matrix;mitochondrion","Carbon metabolism;Glycine, serine and threonine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways",null,null,1,1,1,"11.6","11.6","11.6","18.884",0,"11.959",20381000,3,"0.0122403",1,"0.517485","0.0393174","sp|P23434|GCSH_HUMAN","sp|P23434|GCSH_HUMAN",1199,"P23434","GCSH_HUMAN","Glycine cleavage system H protein, mitochondrial {ECO:0000303|PubMed:1671321}",null,"GCSH"]
["13.5988","17.5944","14.3711","15.7917",{"$nulls":3},"activation of JUN kinase activity;activation of MAPKKK activity;activation of signaling protein activity involved in unfolded protein response;angiogenesis;cell cycle;cell motility involved in cerebral cortex radial glia guided migration;cellular protein catabolic process;cellular response to epidermal growth factor stimulus;cellular response to interleukin-1;cellular response to lipopolysaccharide;cellular response to tumor necrosis factor;cellular response to vascular endothelial growth factor stimulus;endothelial cell apoptotic process;extrinsic apoptotic signaling pathway via death domain receptors;I-kappaB phosphorylation;inflammatory response;innate immune response;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;layer formation in cerebral cortex;MAPK cascade;negative regulation of angiogenesis;negative regulation of canonical Wnt signaling pathway;negative regulation of catenin import into nucleus;negative regulation of cell proliferation;negative regulation of cellular protein catabolic process;negative regulation of endothelial cell migration;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of epithelial cell migration;negative regulation of epithelial cell proliferation;negative regulation of epithelial to mesenchymal transition;negative regulation of ERK1 and ERK2 cascade;negative regulation of fibroblast proliferation;negative regulation of G0 to G1 transition;negative regulation of GTPase activity;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of MAP kinase activity;negative regulation of NF-kappaB transcription factor activity;negative regulation of phosphatidylinositol 3-kinase activity;negative regulation of phosphatidylinositol 3-kinase signaling;negative regulation of protein phosphorylation;negative regulation of protein serine/threonine kinase activity;negative regulation of Ras protein signal transduction;negative regulation of toll-like receptor 4 signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of vascular endothelial growth factor receptor signaling pathway;negative regulation of vascular endothelial growth factor signaling pathway;neuron projection morphogenesis;positive regulation of apoptotic process;positive regulation of apoptotic signaling pathway;positive regulation of cell cycle arrest;positive regulation of dendrite development;positive regulation of IRE1-mediated unfolded protein response;positive regulation of JNK cascade;positive regulation of JUN kinase activity;positive regulation of MAPK cascade;positive regulation of neuron migration;positive regulation of neuron projection development;positive regulation of proteasomal protein catabolic process;positive regulation of protein catabolic process;positive regulation of protein serine/threonine kinase activity;positive regulation of synapse maturation;positive regulation of transcription from RNA polymerase II promoter;reelin-mediated signaling pathway;regulation of growth;regulation of GTPase activity;regulation of I-kappaB kinase/NF-kappaB signaling;regulation of p38MAPK cascade;regulation of protein complex assembly;regulation of protein heterodimerization activity;tube formation;vascular endothelial growth factor receptor-2 signaling pathway","14-3-3 protein binding;cadherin binding;death receptor binding;GTPase activator activity;identical protein binding;kinase binding;mitogen-activated protein kinase kinase binding;mitogen-activated protein kinase kinase kinase binding;phosphatidylinositol 3-kinase binding;phosphatidylinositol 3-kinase regulatory subunit binding;phosphatidylinositol-3-phosphate binding;phosphatidylinositol-4-phosphate binding;protein complex binding;protein homodimerization activity;protein kinase binding;protein phosphatase 2A binding;SH3 domain binding;signaling adaptor activity;vascular endothelial growth factor receptor 2 binding","AIP1-IRE1 complex;axon;cerebellar mossy fiber;climbing fiber;cytoplasm;cytosol;dendrite;endocytic vesicle;extracellular exosome;intrinsic component of the cytoplasmic side of the plasma membrane;neuronal cell body;neuronal cell body membrane;parallel fiber;plasma membrane","Apoptosis;TNF signaling pathway",null,null,22,22,19,"25.5","25.5","22.6","131.62",0,"74.584",715420000,99,"0.0805673",1,"0.515172","0.242966","sp|Q5VWQ8|DAB2P_HUMAN;tr|H0Y3A3|H0Y3A3_HUMAN;tr|F6R503|F6R503_HUMAN;tr|F8WA47|F8WA47_HUMAN;tr|A0A0A0MQZ2|A0A0A0MQZ2_HUMAN;tr|B7ZCA0|B7ZCA0_HUMAN;sp|Q96PV0|SYGP1_HUMAN","sp|Q5VWQ8|DAB2P_HUMAN;tr|H0Y3A3|H0Y3A3_HUMAN",2765,"Q5VWQ8","DAB2P_HUMAN","Disabled homolog 2-interacting protein","AB2 interaction protein;AB2-interacting protein","DAB2IP"]
["17.9636","19.2691","18.2541","17.9489",{"$nulls":3},"cell division;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;protein localization to centrosome;regulation of G2/M transition of mitotic cell cycle",null,"apical part of cell;centriole;centrosome;ciliary basal body;cytosol;pericentriolar material;spindle pole",{"$nulls":3},5,5,5,"11.4","11.4","11.4","71.965",0,"12.769",81058000,19,"0.281694",1,"0.51484","0.768016","sp|Q8NHV4|NEDD1_HUMAN","sp|Q8NHV4|NEDD1_HUMAN",3350,"Q8NHV4","NEDD1_HUMAN","Protein NEDD1",null,"NEDD1"]
["17.278","17.3181","17.9304","15.6378",{"$nulls":4},"RNA binding",{"$nulls":4},5,3,3,"18.8","14.1","14.1","34.861","0.00024845","6.2257",34876000,4,"0.156262",1,"0.513999","0.448318","tr|E5RJN7|E5RJN7_HUMAN;tr|A0A0A0MTC4|A0A0A0MTC4_HUMAN;tr|A0A0A0MTD1|A0A0A0MTD1_HUMAN;tr|F8VPI7|F8VPI7_HUMAN;tr|E7EPX0|E7EPX0_HUMAN;tr|A0A0A0MTC6|A0A0A0MTC6_HUMAN;tr|E7EVJ4|E7EVJ4_HUMAN;tr|E9PH62|E9PH62_HUMAN;tr|A0A0A0MTC5|A0A0A0MTC5_HUMAN;sp|Q9NUL3|STAU2_HUMAN;tr|G5EA18|G5EA18_HUMAN;tr|E7EVI1|E7EVI1_HUMAN;tr|E5RJ67|E5RJ67_HUMAN;tr|H0YBY0|H0YBY0_HUMAN;tr|E5RFK1|E5RFK1_HUMAN","tr|E5RJN7|E5RJN7_HUMAN;tr|A0A0A0MTC4|A0A0A0MTC4_HUMAN;tr|A0A0A0MTD1|A0A0A0MTD1_HUMAN;tr|F8VPI7|F8VPI7_HUMAN;tr|E7EPX0|E7EPX0_HUMAN;tr|A0A0A0MTC6|A0A0A0MTC6_HUMAN;tr|E7EVJ4|E7EVJ4_HUMAN;tr|E9PH62|E9PH62_HUMAN;tr|A0A0A0MTC5|A0A0A0MTC5_HUMAN;sp|Q9NUL3|STAU2_HUMAN;tr|G5EA18|G5EA18_HUMAN;tr|E7EVI1|E7EVI1_HUMAN",4463,"E5RJN7","E5RJN7_HUMAN",null,null,"STAU2"]
[1,"17.592",1,"16.5762",{"$nulls":3},"BMP signaling pathway;histone H2B conserved C-terminal lysine deubiquitination;monoubiquitinated protein deubiquitination;pathway-restricted SMAD protein phosphorylation;protein deubiquitination;transforming growth factor beta receptor signaling pathway;ubiquitin-dependent protein catabolic process","cysteine-type endopeptidase activity;identical protein binding;SMAD binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;transforming growth factor beta receptor binding;ubiquitin modification-dependent histone binding","cytoplasm;cytosol;mitochondrion;nucleus","Mitophagy - animal",null,null,5,5,5,"6.7","6.7","6.7","112.42","0.00026192","7.3431",30210000,5,"0.013921",1,"0.507894","0.0446349","sp|Q9Y4E8|UBP15_HUMAN;tr|F8VVY7|F8VVY7_HUMAN;tr|F8VZG8|F8VZG8_HUMAN;tr|F8W0H4|F8W0H4_HUMAN;tr|H0YI31|H0YI31_HUMAN;tr|G5E9A6|G5E9A6_HUMAN;sp|Q13107|UBP4_HUMAN;sp|P51784|UBP11_HUMAN","sp|Q9Y4E8|UBP15_HUMAN",5014,"Q9Y4E8","UBP15_HUMAN","Ubiquitin carboxyl-terminal hydrolase 15",null,"USP15"]
["20.1239","19.5192","19.7556","18.8737",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding","nucleoplasm;nucleus","Spliceosome",null,null,20,20,20,"23.9","23.9","23.9","118.29",0,"79.828",921040000,93,"0.353453",1,"0.506916","0.94811","sp|O15042|SR140_HUMAN;tr|E7ET15|E7ET15_HUMAN;tr|H0Y8D9|H0Y8D9_HUMAN;tr|E7EW00|E7EW00_HUMAN;tr|H7C4V2|H7C4V2_HUMAN;tr|C9J5L1|C9J5L1_HUMAN;tr|U3KPT1|U3KPT1_HUMAN;tr|C9JDJ7|C9JDJ7_HUMAN","sp|O15042|SR140_HUMAN;tr|E7ET15|E7ET15_HUMAN",316,"O15042","SR140_HUMAN","U2 snRNP-associated SURP motif-containing protein",null,"U2SURP"]
["24.2876","23.6701","24.0788","22.867",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosome biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","cadherin binding;RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;mitochondrion","Ribosome",null,null,5,5,5,"22.2","22.2","22.2","13.293",0,"14.543",1002100000,56,"0.272134",1,"0.505953","0.744026","sp|P49207|RL34_HUMAN","sp|P49207|RL34_HUMAN",1561,"P49207","RL34_HUMAN","60S ribosomal protein L34",null,"RPL34"]
["23.6434","24.1229","23.743","23.021",{"$nulls":3},"cellular response to interferon-gamma;negative regulation of formation of translation preinitiation complex;negative regulation of translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;focal adhesion;GAIT complex;intracellular ribonucleoprotein complex;large ribosomal subunit;membrane;nucleolus;nucleus","Ribosome",null,null,8,8,8,"36.9","36.9","36.9","23.577",0,"30.301",2510000000,144,"0.43532",1,"0.5011","1.15632","sp|P40429|RL13A_HUMAN;tr|M0QYS1|M0QYS1_HUMAN;tr|Q8J015|Q8J015_HUMAN;sp|Q6NVV1|R13P3_HUMAN;tr|M0QZU1|M0QZU1_HUMAN;tr|A0A096LPE0|A0A096LPE0_HUMAN","sp|P40429|RL13A_HUMAN;tr|M0QYS1|M0QYS1_HUMAN;tr|Q8J015|Q8J015_HUMAN",1439,"P40429","RL13A_HUMAN","60S ribosomal protein L13a",null,"RPL13A"]
["22.6626","21.5818","22.1676","21.075",{"$nulls":3},"asparagine metabolic process;glutamine metabolic process;neutrophil degranulation;oxaloacetate metabolic process","omega-amidase activity","centrosome;cytosol;extracellular exosome;extracellular region;mitochondrion;specific granule lumen;tertiary granule lumen","Alanine, aspartate and glutamate metabolism;Metabolic pathways",null,null,11,11,11,"52.2","52.2","52.2","30.608",0,"73.121",613720000,51,"0.235512",1,"0.500865","0.651816","sp|Q9NQR4|NIT2_HUMAN;tr|H7C579|H7C579_HUMAN;tr|F8WF70|F8WF70_HUMAN","sp|Q9NQR4|NIT2_HUMAN;tr|H7C579|H7C579_HUMAN",4391,"Q9NQR4","NIT2_HUMAN","Omega-amidase NIT2",null,"NIT2"]
["18.4736","18.8565","18.8369","17.4937",{"$nulls":3},"cellular response to DNA damage stimulus;negative regulation of cell growth;positive regulation of cell growth;positive regulation of signal transduction;regulation of protein stability","p53 binding;RNA binding","granular component;nucleolus;nucleoplasm",{"$nulls":3},7,7,7,"19.7","19.7","19.7","61.124",0,"42.226",251560000,29,"0.260813",1,"0.499756","0.715582","sp|Q9NXV6|CARF_HUMAN;tr|J3KNE1|J3KNE1_HUMAN;tr|D6RGD2|D6RGD2_HUMAN","sp|Q9NXV6|CARF_HUMAN",4554,"Q9NXV6","CARF_HUMAN","CDKN2A-interacting protein",null,"CDKN2AIP"]
["21.8558","21.3045","21.9404","20.2216",{"$nulls":3},"antigen processing and presentation;endosome organization;neutrophil degranulation;plasma membrane to endosome transport;protein transport;regulation of endocytosis","GDP binding;GTP binding;GTPase activity;GTP-dependent protein binding","anchored component of synaptic vesicle membrane;early endosome;early endosome membrane;endocytic vesicle;endosome;extracellular exosome;intracellular;intracellular membrane-bounded organelle;melanosome;membrane;plasma membrane;secretory granule membrane","Amoebiasis;Endocytosis;Phagosome;Ras signaling pathway;Tuberculosis;Vasopressin-regulated water reabsorption",null,null,7,4,4,"42.3","27.4","27.4","23.707",0,"18.047",290790000,10,"0.1967",1,"0.499162","0.553091","sp|P61020|RAB5B_HUMAN;tr|F8VUA5|F8VUA5_HUMAN","sp|P61020|RAB5B_HUMAN;tr|F8VUA5|F8VUA5_HUMAN",1824,"P61020","RAB5B_HUMAN","Ras-related protein Rab-5B",null,"RAB5B"]
["17.2564","19.0269","18.062","17.2238",{"$nulls":4},"RNA binding","integral component of membrane",{"$nulls":3},4,4,4,"10.1","10.1","10.1","61.52",0,"12.358",64649000,10,"0.179673",1,"0.498793","0.509269","tr|Q5SZR4|Q5SZR4_HUMAN;sp|Q9Y2W6|TDRKH_HUMAN;tr|F6TB26|F6TB26_HUMAN;tr|E9PKN8|E9PKN8_HUMAN;tr|B7ZAG4|B7ZAG4_HUMAN","tr|Q5SZR4|Q5SZR4_HUMAN;sp|Q9Y2W6|TDRKH_HUMAN;tr|F6TB26|F6TB26_HUMAN",4945,"Q5SZR4","Q5SZR4_HUMAN"]
["18.7577","18.7817","18.1628","18.3796",{"$nulls":3},"double-strand break repair via homologous recombination;embryonic organ development;homeostasis of number of cells;multicellular organism growth;positive regulation of epithelial cell proliferation;protein deubiquitination;regulation of protein monoubiquitination;seminiferous tubule development;single fertilization;skeletal system morphogenesis;skin development;spermatogenesis;viral process","thiol-dependent ubiquitinyl hydrolase activity","intracellular membrane-bounded organelle;late endosome;lysosome;nucleoplasm;nucleus","Fanconi anemia pathway",null,null,11,11,11,"23.6","23.6","23.6","76.21",0,"34.594",299200000,44,"1.3496",1,"0.498498","4.56925","sp|Q8TAF3|WDR48_HUMAN;tr|F8W9K4|F8W9K4_HUMAN;tr|F8W7Q3|F8W7Q3_HUMAN;tr|C9JC24|C9JC24_HUMAN;tr|F8W7Y5|F8W7Y5_HUMAN;tr|F8W6P2|F8W6P2_HUMAN","sp|Q8TAF3|WDR48_HUMAN",3358,"Q8TAF3","WDR48_HUMAN","WD repeat-containing protein 48",null,"WDR48"]
["20.6958","21.0132","20.6811","20.0376",{"$nulls":3},"cellular response to leukemia inhibitory factor;negative regulation of RNA-directed 5'-3' RNA polymerase activity;nuclear-transcribed mRNA poly(A) tail shortening;regulation of translational initiation;RNA secondary structure unwinding;translational initiation;viral process","ATP binding;ATPase activity;ATP-dependent RNA helicase activity;helicase activity;RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 4F complex;nucleolus;perinuclear region of cytoplasm","RNA transport",null,null,17,6,6,"45.9","20.4","20.4","46.402",0,"18.387",259790000,29,"0.520713",1,"0.495184","1.3804","sp|Q14240|IF4A2_HUMAN;tr|E7EQG2|E7EQG2_HUMAN;tr|J3KSN7|J3KSN7_HUMAN;tr|E7EMV8|E7EMV8_HUMAN;tr|E9PBH4|E9PBH4_HUMAN;tr|F8WE11|F8WE11_HUMAN;tr|C9JUF0|C9JUF0_HUMAN","sp|Q14240|IF4A2_HUMAN;tr|E7EQG2|E7EQG2_HUMAN",2349,"Q14240","IF4A2_HUMAN","Eukaryotic initiation factor 4A-II","IF4A-II;IF-4A-II","EIF4A2"]
[1,"16.1138","15.1242",1,{"$nulls":3},"MAPK cascade;negative regulation of Ras protein signal transduction;signal transduction","GTPase activator activity;metal ion binding","cytoplasm;cytosol;intrinsic component of the cytoplasmic side of the plasma membrane;perinuclear region of cytoplasm","MAPK signaling pathway;Ras signaling pathway;Viral carcinogenesis",null,null,3,3,3,"5.9","5.9","5.9","96.613",0,"9.9921",39490000,11,"0.0149355",1,"0.49477","0.0478357","sp|Q15283|RASA2_HUMAN;tr|A0A0A0MSJ9|A0A0A0MSJ9_HUMAN;tr|D6RBA9|D6RBA9_HUMAN","sp|Q15283|RASA2_HUMAN;tr|A0A0A0MSJ9|A0A0A0MSJ9_HUMAN",2466,"Q15283","RASA2_HUMAN","Ras GTPase-activating protein 2",null,"RASA2"]
["19.7129","19.5368","20.4315","17.8288",{"$nulls":3},"metabolic process","catalytic activity",{"$nulls":4},9,9,9,"27.3","27.3","27.3","63.652",0,"28.774",112810000,23,"0.130215",1,"0.494736","0.37931","tr|E9PF16|E9PF16_HUMAN;sp|Q96CM8|ACSF2_HUMAN;tr|D6RF87|D6RF87_HUMAN","tr|E9PF16|E9PF16_HUMAN;sp|Q96CM8|ACSF2_HUMAN",3635,"E9PF16","E9PF16_HUMAN",null,null,"ACSF2"]
["17.0552","17.9537","17.7911","16.2286",{"$nulls":3},"signal transduction","GTPase activator activity",{"$nulls":4},11,11,11,"18.4","18.4","18.4","90.873",0,"18.721",212040000,19,"0.195041",1,"0.494624","0.548837","tr|Q1RLN5|Q1RLN5_HUMAN;sp|Q8IWW6|RHG12_HUMAN;tr|H0Y5D8|H0Y5D8_HUMAN","tr|Q1RLN5|Q1RLN5_HUMAN;sp|Q8IWW6|RHG12_HUMAN",3136,"Q1RLN5","Q1RLN5_HUMAN"]
["23.2346","21.9626","23.5453","20.6628",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;inflammatory response;mRNA processing;mRNA splicing, via spliceosome;response to lipopolysaccharide;RNA metabolic process","AU-rich element binding;protein kinase binding;RNA binding","intracellular ribonucleoprotein complex;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"23.3","23.3","23.3","30.84",0,"48.833",930970000,41,"0.106072",1,"0.494524","0.313919","sp|Q13151|ROA0_HUMAN","sp|Q13151|ROA0_HUMAN",2212,"Q13151","ROA0_HUMAN","Heterogeneous nuclear ribonucleoprotein A0","nRNP A0","HNRNPA0"]
["18.3757","19.0321","18.4601","17.9592",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;negative regulation of RNA export from nucleus;nuclear pore complex assembly;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;tRNA export from nucleus;viral entry into host cell;viral penetration into host nucleus;viral process;viral transcription","DNA binding;identical protein binding;metal ion binding;nuclear localization sequence binding;nucleocytoplasmic transporter activity;protein membrane anchor;structural constituent of nuclear pore","cytosol;host cell;nuclear inclusion body;nuclear membrane;nuclear periphery;nuclear pore;nuclear pore nuclear basket;nucleolus;nucleoplasm","RNA transport",null,null,17,17,17,"18.2","18.2","18.2","153.94",0,"38.023",279980000,58,"0.451171",1,"0.494252","1.19728","sp|P49790|NU153_HUMAN","sp|P49790|NU153_HUMAN",1602,"P49790","NU153_HUMAN","Nuclear pore complex protein Nup153",null,"NUP153"]
["18.9592","19.8714","18.9109","18.9328",{"$nulls":3},"fructose 2,6-bisphosphate metabolic process;fructose metabolic process;glucose catabolic process;glycolytic process;lactate metabolic process;positive regulation of glucokinase activity;positive regulation of glycolytic process;positive regulation of insulin secretion;response to glucose","6-phosphofructo-2-kinase activity;ATP binding;fructose-2,6-bisphosphate 2-phosphatase activity;protein kinase binding","cytosol","AMPK signaling pathway;Fructose and mannose metabolism;Metabolic pathways;Thyroid hormone signaling pathway",null,null,14,14,13,"33.1","33.1","31.1","58.476",0,"40.363",194240000,39,"0.406148",1,"0.493443","1.08157","sp|O60825|F262_HUMAN;tr|F6RAZ1|F6RAZ1_HUMAN;tr|F6XNB3|F6XNB3_HUMAN;tr|A0A087X278|A0A087X278_HUMAN;tr|A0A087X2H4|A0A087X2H4_HUMAN;tr|I1Z9G3|I1Z9G3_HUMAN;sp|P16118|F261_HUMAN","sp|O60825|F262_HUMAN",503,"O60825","F262_HUMAN","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2","FK/FBPase 2;PF-2-K/Fru-2,6-P2ase 2","PFKFB2"]
["22.2725","23.0149","22.7519","21.5511",{"$nulls":3},"Leydig cell differentiation;male sex determination;mRNA 3'-splice site recognition;mRNA splicing, via spliceosome;negative regulation of smooth muscle cell proliferation;nuclear body organization;regulation of steroid biosynthetic process;regulation of transcription, DNA-templated;spliceosomal complex assembly;transcription, DNA-templated","identical protein binding;pre-mRNA branch point binding;RNA binding;transcription corepressor activity;zinc ion binding","nuclear body;nucleoplasm;nucleus;ribosome;spliceosomal complex",{"$nulls":3},9,9,9,"15.6","15.6","15.6","68.329",0,"53.824",821630000,58,"0.25354",1,"0.49219","0.697285","sp|Q15637|SF01_HUMAN;tr|F8WEV5|F8WEV5_HUMAN;tr|C9J792|C9J792_HUMAN;tr|H7C561|H7C561_HUMAN","sp|Q15637|SF01_HUMAN",2505,"Q15637","SF01_HUMAN","Splicing factor 1",null,"SF1"]
["16.8133","16.6921","16.6311","15.8903",{"$nulls":3},"cell differentiation;cell migration;innate immune response;interferon-gamma-mediated signaling pathway;interleukin-12-mediated signaling pathway;interleukin-15-mediated signaling pathway;interleukin-2-mediated signaling pathway;interleukin-7-mediated signaling pathway;interleukin-9-mediated signaling pathway;intracellular signal transduction;MAPK cascade;peptidyl-tyrosine autophosphorylation;positive regulation of sprouting angiogenesis;protein phosphorylation;regulation of cell proliferation;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway;response to antibiotic;transmembrane receptor protein tyrosine kinase signaling pathway;type I interferon signaling pathway","ATP binding;CCR5 chemokine receptor binding;growth hormone receptor binding;metal ion binding;non-membrane spanning protein tyrosine kinase activity;protein phosphatase binding;protein tyrosine kinase activity;Ras guanyl-nucleotide exchange factor activity;receptor binding;ubiquitin protein ligase binding","cytoplasm;cytoskeleton;cytosol;endosome;extrinsic component of cytoplasmic side of plasma membrane;focal adhesion;nucleus","EGFR tyrosine kinase inhibitor resistance;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Signaling pathways regulating pluripotency of stem cells;Th1 and Th2 cell differentiation;Th17 cell differentiation;Toxoplasmosis;Tuberculosis;Viral carcinogenesis",null,null,19,19,19,"18.9","18.9","18.9","133.28",0,"45.494",599140000,78,"0.494535",1,"0.491947","1.31075","sp|P23458|JAK1_HUMAN","sp|P23458|JAK1_HUMAN",1201,"P23458","JAK1_HUMAN","Tyrosine-protein kinase JAK1",null,"JAK1"]
["20.2602","20.4211","20.7444","18.9535",{"$nulls":3},"cilium assembly;developmental process;protein folding;protein localization to pericentriolar material","unfolded protein binding","cytoplasm;cytoplasmic dynein complex",{"$nulls":3},11,11,11,"46.5","46.5","46.5","40.822",0,"55.713",219960000,41,"0.19427",1,"0.49166","0.54686","sp|Q8IVD9|NUDC3_HUMAN","sp|Q8IVD9|NUDC3_HUMAN",3113,"Q8IVD9","NUDC3_HUMAN","NudC domain-containing protein 3",null,"NUDCD3"]
["19.914","22.1121","20.0494","20.9962",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;mitotic cell cycle checkpoint;mitotic sister chromatid segregation;mitotic spindle assembly checkpoint;negative regulation of apoptotic process;negative regulation of mitotic cell cycle;negative regulation of protein catabolic process;negative regulation of ubiquitin protein ligase activity;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of mitotic cell cycle spindle assembly checkpoint;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;sister chromatid cohesion","identical protein binding;protein homodimerization activity","condensed chromosome kinetochore;cytosol;kinetochore;mitotic spindle;nucleoplasm;nucleus;perinuclear region of cytoplasm;spindle pole","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation",null,null,7,7,7,"28.3","28.3","28.3","23.51",0,"41.379",427120000,48,"0.141617",1,"0.490266","0.409694","sp|Q13257|MD2L1_HUMAN","sp|Q13257|MD2L1_HUMAN",2228,"Q13257","MD2L1_HUMAN","Mitotic spindle assembly checkpoint protein MAD2A","sMAD2","MAD2L1"]
["20.8736","20.9214","19.8383","20.9783",{"$nulls":3},"arachidonic acid metabolic process;fatty acid catabolic process","acylglycerol lipase activity;amidase activity;anandamide amidohydrolase activity;fatty acid amide hydrolase activity;oleamide hydrolase activity","cytoskeleton;endoplasmic reticulum membrane;integral component of membrane;organelle membrane","Retrograde endocannabinoid signaling",null,null,10,10,10,"27.5","27.5","27.5","63.065",0,"28.461",494850000,36,"0.31738",1,"0.489182","0.857488","sp|O00519|FAAH1_HUMAN","sp|O00519|FAAH1_HUMAN",239,"O00519","FAAH1_HUMAN","Fatty-acid amide hydrolase 1",null,"FAAH"]
["17.5105","15.8215","16.805","15.5498",{"$nulls":3},"RNA processing","double-stranded RNA adenosine deaminase activity;RNA binding","nucleolus;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"6.9","6.9","6.9","132.65",0,"9.8978",111480000,14,"0.162389",1,"0.488597","0.464358","tr|H0YCK3|H0YCK3_HUMAN;sp|P55265|DSRAD_HUMAN","tr|H0YCK3|H0YCK3_HUMAN;sp|P55265|DSRAD_HUMAN",1765,"H0YCK3","H0YCK3_HUMAN",null,null,"ADAR"]
["16.7912","17.5879","17.1295","16.2729",{"$nulls":3},"7-methylguanosine mRNA capping;G1/S transition of mitotic cell cycle;G2/M transition of mitotic cell cycle;nucleotide-excision repair, preincision complex assembly;positive regulation of cyclin-dependent protein serine/threonine kinase activity;positive regulation of phosphorylation of RNA polymerase II C-terminal domain;positive regulation of transcription from RNA polymerase II promoter;protein phosphorylation;protein stabilization;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair","cyclin-dependent protein serine/threonine kinase regulator activity;kinase activity","cyclin-dependent protein kinase activating kinase holoenzyme complex;holo TFIIH complex;nucleoplasm;nucleus;TFIIK complex","Basal transcription factors;Cell cycle;Nucleotide excision repair",null,null,6,6,6,"26.6","26.6","26.6","37.643",0,"19.715",176240000,21,"0.308384",1,"0.488374","0.834932","sp|P51946|CCNH_HUMAN;tr|D6RHI7|D6RHI7_HUMAN;tr|D6RG18|D6RG18_HUMAN","sp|P51946|CCNH_HUMAN;tr|D6RHI7|D6RHI7_HUMAN;tr|D6RG18|D6RG18_HUMAN",1672,"P51946","CCNH_HUMAN","Cyclin-H",null,"CCNH"]
["23.7219","22.6623","23.5403","21.8687",{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,"44.2","44.2","44.2","10.32",0,"20.963",757080000,33,"0.1733",1,"0.487625","0.492763","tr|A0A087X2D0|A0A087X2D0_HUMAN;sp|P84103|SRSF3_HUMAN","tr|A0A087X2D0|A0A087X2D0_HUMAN;sp|P84103|SRSF3_HUMAN",2013,"A0A087X2D0","A0A087X2D0_HUMAN",null,null,"SRSF3"]
["16.2452","13.2084","14.3811","14.0976",{"$nulls":3},"O-glycan processing;phosphatidylinositol-mediated signaling;stimulatory C-type lectin receptor signaling pathway","extracellular matrix structural constituent","cytoplasm;extracellular exosome;extracellular space;Golgi lumen;mucus layer;plasma membrane","IL-17 signaling pathway",null,null,4,4,4,"3.4","3.4","3.4","585.56","0.00025342","6.6464",68430000,9,"0.108165",1,"0.487474","0.319651","sp|P98088|MUC5A_HUMAN","sp|P98088|MUC5A_HUMAN",2018,"P98088","MUC5A_HUMAN","Mucin-5AC {ECO:0000305}","UC-5AC {ECO:0000305}","MUC5AC"]
["16.1309","16.8292","15.7789","16.2065",{"$nulls":3},"amyloid-beta clearance;cellular response to fatty acid;cellular response to low-density lipoprotein particle stimulus;cholesterol homeostasis;cholesterol import;cholesterol metabolic process;cholesterol transport;chylomicron remnant clearance;endocytosis;intestinal cholesterol absorption;lipid metabolic process;lipoprotein catabolic process;long-term memory;low-density lipoprotein particle clearance;membrane organization;negative regulation of amyloid fibril formation;negative regulation of astrocyte activation;negative regulation of gene expression;negative regulation of microglial cell activation;negative regulation of protein metabolic process;phospholipid transport;plasma lipoprotein particle clearance;positive regulation of amyloid-beta clearance;positive regulation of endocytosis;positive regulation of gene expression;positive regulation of inflammatory response;positive regulation of lipoprotein particle clearance;positive regulation of lysosomal protein catabolic process;positive regulation of triglyceride biosynthetic process;receptor-mediated endocytosis;receptor-mediated endocytosis involved in cholesterol transport;regulation of cholesterol homeostasis;regulation of cholesterol metabolic process;regulation of phosphatidylcholine catabolic process;regulation of protein metabolic process;response to caloric restriction","amyloid-beta binding;calcium ion binding;clathrin heavy chain binding;identical protein binding;low-density lipoprotein particle binding;low-density lipoprotein receptor activity;protease binding;very-low-density lipoprotein particle receptor activity;virus receptor activity","apical part of cell;basolateral plasma membrane;cell surface;clathrin-coated endocytic vesicle membrane;clathrin-coated pit;early endosome;endolysosome membrane;endosome membrane;external side of plasma membrane;Golgi apparatus;integral component of plasma membrane;intracellular;late endosome;low-density lipoprotein particle;lysosome;membrane;PCSK9-LDLR complex;plasma membrane;receptor complex;somatodendritic compartment;sorting endosome","Aldosterone synthesis and secretion;Bile secretion;Cholesterol metabolism;Cortisol synthesis and secretion;Cushing syndrome;Endocytosis;Hepatitis C;Ovarian steroidogenesis;Toxoplasmosis",null,null,2,2,2,"3.1","3.1","3.1","95.375","0.00024802","6.2044",30049000,2,"0.448539",1,"0.487365","1.19046","sp|P01130|LDLR_HUMAN;tr|J3KMZ9|J3KMZ9_HUMAN;tr|H0YM92|H0YM92_HUMAN;tr|H0YMD1|H0YMD1_HUMAN","sp|P01130|LDLR_HUMAN;tr|J3KMZ9|J3KMZ9_HUMAN;tr|H0YM92|H0YM92_HUMAN;tr|H0YMD1|H0YMD1_HUMAN",818,"P01130","LDLR_HUMAN","Low-density lipoprotein receptor","DL receptor","LDLR"]
["18.3964","18.1724","18.2523","17.343",{"$nulls":3},"muscle organ development;positive regulation of striated muscle tissue development;positive regulation of transcription from RNA polymerase II promoter;smooth muscle cell differentiation","cadherin binding;RNA polymerase II transcription coactivator activity;transcription coactivator activity","nucleus",{"$nulls":3},5,5,5,"8.5","8.5","8.5","118.13","0.00068603","4.5015",148750000,8,"0.389554",1,"0.486692","1.03935","sp|Q9ULH7|MKL2_HUMAN;tr|I3L2S3|I3L2S3_HUMAN;tr|B0QY84|B0QY84_HUMAN;tr|E7ER32|E7ER32_HUMAN;tr|A0A087X287|A0A087X287_HUMAN;tr|B0QY83|B0QY83_HUMAN;tr|A0A087WU73|A0A087WU73_HUMAN;sp|Q969V6|MKL1_HUMAN;tr|W0Z7M9|W0Z7M9_HUMAN;sp|Q8IZQ8|MYCD_HUMAN","sp|Q9ULH7|MKL2_HUMAN;tr|I3L2S3|I3L2S3_HUMAN",4817,"Q9ULH7","MKL2_HUMAN","MKL/myocardin-like protein 2",null,"MKL2"]
["19.4691","19.2833","19.5042","18.2759",{"$nulls":3},"methionyl-tRNA aminoacylation;tRNA aminoacylation for protein translation","ATP binding;methionine-tRNA ligase activity","mitochondrial matrix","Aminoacyl-tRNA biosynthesis;Metabolic pathways;Selenocompound metabolism",null,null,4,4,4,12,12,12,"66.59",0,"10.404",145100000,15,"0.287542",1,"0.486159","0.782683","sp|Q96GW9|SYMM_HUMAN","sp|Q96GW9|SYMM_HUMAN",3708,"Q96GW9","SYMM_HUMAN","Methionine--tRNA ligase, mitochondrial",null,"MARS2"]
["22.0087","22.0321","22.5637","20.5057",{"$nulls":3},"animal organ regeneration;defense response to bacterium;hippocampus development;neutrophil degranulation;phagocytosis;positive regulation of angiogenesis;positive regulation of DNA binding transcription factor activity;positive regulation of DNA metabolic process;positive regulation of endothelial cell migration;response to glucocorticoid;response to growth factor","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;phospholipase A2 inhibitor activity","axon;cytoplasm;cytosol;dendrite;extracellular exosome;membrane;neuronal cell body;phagocytic vesicle membrane;plasma membrane;specific granule",{"$nulls":3},15,15,15,"52.6","52.6","52.6","36.375",0,"44.765",808920000,45,"0.1653",1,"0.485679","0.471955","sp|P12429|ANXA3_HUMAN;tr|D6RA82|D6RA82_HUMAN;tr|D6RFG5|D6RFG5_HUMAN;tr|D6RCA8|D6RCA8_HUMAN;tr|D6RAZ8|D6RAZ8_HUMAN;tr|D6RFJ9|D6RFJ9_HUMAN","sp|P12429|ANXA3_HUMAN;tr|D6RA82|D6RA82_HUMAN;tr|D6RFG5|D6RFG5_HUMAN",1014,"P12429","ANXA3_HUMAN","Annexin A3",null,"ANXA3"]
["14.9726","15.9147","14.9885","14.9286",{"$nulls":3},"metabolic process","hydrolase activity",{"$nulls":4},1,1,1,"2.3","2.3","2.3","80.464","0.003706","3.0203",10312000,3,"0.384992",1,"0.485084","1.02778","tr|F8W1I9|F8W1I9_HUMAN;sp|Q6JQN1|ACD10_HUMAN","tr|F8W1I9|F8W1I9_HUMAN;sp|Q6JQN1|ACD10_HUMAN",2827,"F8W1I9","F8W1I9_HUMAN",null,null,"ACAD10"]
["19.027","19.3494","19.4661","17.9413",{"$nulls":3},"histone acetylation;regulation of growth;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated",null,"NuA4 histone acetyltransferase complex;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"17.2","17.2","17.2","22.417",0,"17.824",192330000,23,"0.223631",1,"0.484496","0.621734","sp|Q9NV56|MRGBP_HUMAN","sp|Q9NV56|MRGBP_HUMAN",4479,"Q9NV56","MRGBP_HUMAN","MRG/MORF4L-binding protein",null,"MRGBP"]
["16.9497","15.638","15.4497","16.1702",{"$nulls":3},"enamel mineralization;magnesium ion homeostasis;metal ion homeostasis;response to stimulus;visual perception","magnesium ion transmembrane transporter activity;sodium ion transmembrane transporter activity","basolateral plasma membrane;dendrite;integral component of membrane;neuronal cell body;protein complex",{"$nulls":3},3,3,3,"5.7","5.7","5.7","86.606","0.00024137","5.6097",27991000,6,"0.233494",1,"0.483913","0.646714","sp|Q6P4Q7|CNNM4_HUMAN","sp|Q6P4Q7|CNNM4_HUMAN",2869,"Q6P4Q7","CNNM4_HUMAN","Metal transporter CNNM4",null,"CNNM4"]
["18.4679","18.7022","18.593","17.6108",{"$nulls":3},"base-excision repair, DNA ligation;cell cycle;cell division;DNA biosynthetic process;DNA ligation;DNA replication;double-strand break repair;double-strand break repair via alternative nonhomologous end joining;double-strand break repair via homologous recombination;mitochondrial DNA repair;mitochondrion organization;negative regulation of mitochondrial DNA replication;nucleotide-excision repair, DNA gap filling;transcription-coupled nucleotide-excision repair","ATP binding;DNA binding;DNA ligase (ATP) activity;DNA ligase activity;zinc ion binding","DNA ligase III-XRCC1 complex;mitochondrion;nucleoplasm;nucleus","Base excision repair",null,null,18,18,18,"22.4","22.4","22.4","112.91",0,"43.397",344480000,54,"0.357007",1,"0.483172","0.957063","sp|P49916|DNLI3_HUMAN;tr|K7ERZ5|K7ERZ5_HUMAN;tr|K7EQB6|K7EQB6_HUMAN;tr|K7ENR9|K7ENR9_HUMAN;tr|K7ELY6|K7ELY6_HUMAN","sp|P49916|DNLI3_HUMAN;tr|K7ERZ5|K7ERZ5_HUMAN",1614,"P49916","DNLI3_HUMAN","DNA ligase 3",null,"LIG3"]
["20.7093","21.0358","20.809","19.97",{"$nulls":3},"genitalia development;protein folding;protein targeting to mitochondrion;visual perception",null,"integral component of membrane;mitochondrial inner membrane;mitochondrion;protein complex",{"$nulls":3},8,8,8,"64.7","64.7","64.7","12.498",0,"74.058",700900000,54,"0.40282",1,"0.483053","1.07308","sp|Q96DA6|TIM14_HUMAN;tr|F2Z3A7|F2Z3A7_HUMAN;tr|G5E9V2|G5E9V2_HUMAN","sp|Q96DA6|TIM14_HUMAN;tr|F2Z3A7|F2Z3A7_HUMAN",3649,"Q96DA6","TIM14_HUMAN","Mitochondrial import inner membrane translocase subunit TIM14",null,"DNAJC19"]
["18.207","17.1689","18.5095","15.901",{"$nulls":3},"cellular response to insulin stimulus;protein localization to plasma membrane;protein transport","Rab guanyl-nucleotide exchange factor activity","cytoplasmic vesicle membrane;cytosol;insulin-responsive compartment;plasma membrane;retromer complex",{"$nulls":3},13,13,13,"9.1","9.1","9.1","212.71",0,"25.334",175230000,27,"0.117058",1,"0.482693","0.343865","tr|R4GNB2|R4GNB2_HUMAN;tr|R4GN35|R4GN35_HUMAN;sp|Q5VZ89|DEN4C_HUMAN;tr|X6RAE7|X6RAE7_HUMAN;tr|X6R5W5|X6R5W5_HUMAN;tr|R4GMN2|R4GMN2_HUMAN;tr|A0A0A0MRX3|A0A0A0MRX3_HUMAN","tr|R4GNB2|R4GNB2_HUMAN;tr|R4GN35|R4GN35_HUMAN;sp|Q5VZ89|DEN4C_HUMAN",5303,"R4GNB2","DEN4C_HUMAN","DENN domain-containing protein 4C",null,"DENND4C"]
["19.82","19.6322","20.1039","18.3844",{"$nulls":3},"tRNA processing","protein kinase binding","cytosol;EKC/KEOPS complex;nucleus",{"$nulls":3},3,3,3,"33.7","33.7","33.7","19.661",0,"22.567",32771000,9,"0.198315",1,"0.481946","0.55723","sp|Q9Y3C4|TPRKB_HUMAN","sp|Q9Y3C4|TPRKB_HUMAN",4979,"Q9Y3C4","TPRKB_HUMAN","EKC/KEOPS complex subunit TPRKB",null,"TPRKB"]
["16.7615","18.7009","17.9683","16.5321",{"$nulls":9},2,2,2,25,25,25,"11.652","0.00025151","6.4899",14261000,4,"0.13745",1,"0.481","0.398623","tr|F2Z3N7|F2Z3N7_HUMAN;tr|C9JZ87|C9JZ87_HUMAN;sp|Q9NUM4|T106B_HUMAN","tr|F2Z3N7|F2Z3N7_HUMAN;tr|C9JZ87|C9JZ87_HUMAN;sp|Q9NUM4|T106B_HUMAN",4465,"F2Z3N7","F2Z3N7_HUMAN",null,null,"TMEM106B"]
["18.9378","18.6368","18.9601","17.6533",{"$nulls":3},"blood circulation;cellular response to heat;muscle contraction;myoblast fusion;plasma membrane repair;regulation of vascular endothelial growth factor receptor signaling pathway","phospholipid binding","caveola;cytoplasmic vesicle;cytoplasmic vesicle membrane;extracellular exosome;integral component of membrane;intracellular membrane-bounded organelle;nuclear envelope;nuclear membrane;plasma membrane",{"$nulls":3},23,23,23,"15.2","15.2","15.2","234.71",0,"58.154",448860000,55,"0.26129",1,"0.480621","0.716783","sp|Q9NZM1|MYOF_HUMAN;tr|H0YD14|H0YD14_HUMAN","sp|Q9NZM1|MYOF_HUMAN;tr|H0YD14|H0YD14_HUMAN",4597,"Q9NZM1","MYOF_HUMAN","Myoferlin",null,"MYOF"]
["19.086","19.5641","19.031","18.6579",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;protein localization to pericentriolar material","DNA binding transcription factor activity;RNA binding;sequence-specific DNA binding","cis-Golgi network;endoplasmic reticulum-Golgi intermediate compartment;Golgi apparatus;Golgi membrane;Golgi stack;integral component of membrane;membrane",{"$nulls":3},86,86,85,"35.7","35.7","35.4","376.01",0,"323.31",3111000000,394,"0.595474",1,"0.48062","1.58508","sp|Q14789|GOGB1_HUMAN;tr|E7EU81|E7EU81_HUMAN;tr|H0Y867|H0Y867_HUMAN;tr|H7C5I7|H7C5I7_HUMAN","sp|Q14789|GOGB1_HUMAN;tr|E7EU81|E7EU81_HUMAN",2395,"Q14789","GOGB1_HUMAN","Golgin subfamily B member 1",null,"GOLGB1"]
["25.3503","25.491","24.8189","25.0639",{"$nulls":3},"translation","rRNA binding;structural constituent of ribosome","small ribosomal subunit","Ribosome",null,null,17,17,17,"57.2","57.2","57.2","22.591",0,"56.997",32354000000,678,"1.11351",1,"0.479248","3.3922","tr|A0A024R4M0|A0A024R4M0_HUMAN;sp|P46781|RS9_HUMAN;tr|B5MCT8|B5MCT8_HUMAN;tr|C9JM19|C9JM19_HUMAN;tr|F2Z3C0|F2Z3C0_HUMAN;tr|A8MXK4|A8MXK4_HUMAN","tr|A0A024R4M0|A0A024R4M0_HUMAN;sp|P46781|RS9_HUMAN;tr|B5MCT8|B5MCT8_HUMAN;tr|C9JM19|C9JM19_HUMAN",1517,"A0A024R4M0","A0A024R4M0_HUMAN"]
["21.5531","21.4968","20.8504","21.2417",{"$nulls":3},"methylation;nucleobase-containing compound metabolic process","thiopurine S-methyltransferase activity","cytosol;extracellular exosome","Drug metabolism - other enzymes",null,null,7,7,7,"32.7","32.7","32.7","28.18",0,"28.352",295130000,32,"0.865369",1,"0.478914","2.42302","sp|P51580|TPMT_HUMAN","sp|P51580|TPMT_HUMAN",1658,"P51580","TPMT_HUMAN","Thiopurine S-methyltransferase",null,"TPMT"]
["18.5867","17.7547","18.5883","16.7956",{"$nulls":3},"intracellular signal transduction;regulation of Rho protein signal transduction","Rho guanyl-nucleotide exchange factor activity","intracellular",{"$nulls":3},10,10,9,"13.9","13.9","12.6","88.857",0,"26.474",297370000,49,"0.170114",1,"0.478743","0.484489","tr|A0A0G2JQ41|A0A0G2JQ41_HUMAN;sp|Q12979|ABR_HUMAN;tr|B7Z683|B7Z683_HUMAN;tr|I3L1U8|I3L1U8_HUMAN;tr|I3L2P5|I3L2P5_HUMAN;tr|I3NI05|I3NI05_HUMAN;tr|A0A0G2JRJ1|A0A0G2JRJ1_HUMAN;tr|I3L3W0|I3L3W0_HUMAN;tr|A0A0G2JSE0|A0A0G2JSE0_HUMAN;tr|A0A0D9SGD7|A0A0D9SGD7_HUMAN;tr|I3L379|I3L379_HUMAN;tr|I3L0R7|I3L0R7_HUMAN","tr|A0A0G2JQ41|A0A0G2JQ41_HUMAN;sp|Q12979|ABR_HUMAN;tr|B7Z683|B7Z683_HUMAN",2189,"A0A0G2JQ41","A0A0G2JQ41_HUMAN",null,null,"ABR"]
["17.031","16.6884","16.998","15.765",{"$nulls":3},"cell cycle;mRNA methylation;mRNA processing;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA splicing",null,"nuclear membrane;nuclear speck;nucleoplasm;nucleus;RNA N6-methyladenosine methyltransferase complex",{"$nulls":3},1,1,1,"3.8","3.8","3.8","44.243",0,"25.479",21580000,6,"0.273461",1,"0.478201","0.747356","sp|Q15007|FL2D_HUMAN","sp|Q15007|FL2D_HUMAN",2420,"Q15007","FL2D_HUMAN","Pre-mRNA-splicing regulator WTAP",null,"WTAP"]
[1,"17.6754",1,"16.7199",{"$nulls":3},"histone H3 acetylation;histone H4 acetylation;intracellular estrogen receptor signaling pathway;mitotic cell cycle;positive regulation of gene expression;positive regulation of transcription, DNA-templated;protein deubiquitination;regulation of histone deacetylation;regulation of protein phosphorylation;regulation of protein stability;regulation of transcription from RNA polymerase II promoter;regulation of tubulin deacetylation;transcription, DNA-templated","DNA binding transcription factor activity;ligand-dependent nuclear receptor binding;ligand-dependent nuclear receptor transcription coactivator activity;protein domain specific binding;thiol-dependent ubiquitinyl hydrolase activity;transcription coactivator activity","Ada2/Gcn5/Ada3 transcription activator complex;intracellular;mitotic spindle;nucleoplasm;nucleus;SAGA complex;STAGA complex;transcription factor TFTC complex","Human papillomavirus infection",null,null,8,8,8,28,28,28,"48.902",0,"36.582",241310000,40,"0.0129914",1,"0.477775","0.0416963","sp|O75528|TADA3_HUMAN;tr|C9JMS0|C9JMS0_HUMAN","sp|O75528|TADA3_HUMAN",581,"O75528","TADA3_HUMAN","Transcriptional adapter 3",null,"TADA3"]
["19.4302","18.9866","18.0564","19.4057",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;clathrin coat assembly;clathrin-dependent endocytosis;ephrin receptor signaling pathway;intracellular protein transport;low-density lipoprotein particle clearance;low-density lipoprotein particle receptor catabolic process;membrane organization;microtubule-based movement;regulation of defense response to virus by virus;regulation of endocytosis;Wnt signaling pathway, planar cell polarity pathway","protein transporter activity;transporter activity","AP-2 adaptor complex;clathrin-coated endocytic vesicle;clathrin-coated endocytic vesicle membrane;cytosol;endocytic vesicle membrane;endolysosome membrane;plasma membrane","Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Huntington disease;Synaptic vesicle cycle",null,null,6,6,6,"40.8","40.8","40.8","17.018",0,"21.006",511480000,75,"0.243549",1,"0.477313","0.672108","sp|P53680|AP2S1_HUMAN;tr|M0R0N4|M0R0N4_HUMAN;tr|M0QYZ2|M0QYZ2_HUMAN;tr|X6R390|X6R390_HUMAN;tr|M0QZ21|M0QZ21_HUMAN;tr|M0R1S0|M0R1S0_HUMAN","sp|P53680|AP2S1_HUMAN;tr|M0R0N4|M0R0N4_HUMAN;tr|M0QYZ2|M0QYZ2_HUMAN;tr|X6R390|X6R390_HUMAN;tr|M0QZ21|M0QZ21_HUMAN",1722,"P53680","AP2S1_HUMAN","AP-2 complex subunit sigma",null,"AP2S1"]
["19.9005",1,"18.947",1,{"$nulls":3},"transcription initiation from RNA polymerase II promoter",null,"extracellular exosome;nucleoplasm",{"$nulls":3},2,2,2,"13.7","13.7","13.7","15.876","0.0017065","3.4783",30679000,3,"0.0113788",1,"0.476763","0.0365843","sp|Q86WQ0|NR2CA_HUMAN;tr|F5H0B6|F5H0B6_HUMAN;tr|U3KQ53|U3KQ53_HUMAN","sp|Q86WQ0|NR2CA_HUMAN;tr|F5H0B6|F5H0B6_HUMAN;tr|U3KQ53|U3KQ53_HUMAN",3073,"Q86WQ0","NR2CA_HUMAN","Nuclear receptor 2C2-associated protein",null,"NR2C2AP"]
["23.1763","22.9515","23.2209","21.954",{"$nulls":3},"translation","structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;nucleus;plasma membrane","Ribosome",null,null,6,6,2,"34.9","34.9","8.5","12.469",0,"17.596",5897300000,94,"0.270796",1,"0.476497","0.740665","sp|Q969Q0|RL36L_HUMAN","sp|Q969Q0|RL36L_HUMAN",3581,"Q969Q0","RL36L_HUMAN","60S ribosomal protein L36a-like",null,"RPL36AL"]
["25.7053","26.2148","25.8141","25.1552",{"$nulls":3},"maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA binding;RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;membrane;nucleolus","Ribosome",null,null,4,4,4,"24.4","24.4","24.4","14.551",0,"46.032",20250000000,155,"0.429612",1,"0.47543","1.14163","sp|P42766|RL35_HUMAN;tr|F2Z388|F2Z388_HUMAN","sp|P42766|RL35_HUMAN;tr|F2Z388|F2Z388_HUMAN",1481,"P42766","RL35_HUMAN","60S ribosomal protein L35",null,"RPL35"]
["17.7837","17.7229","17.115","17.4418",{"$nulls":4},"chromatin binding;DNA binding transcription factor activity;sequence-specific DNA binding;zinc ion binding","cytosol;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},9,6,5,"16.2","11.9","9.4","79.372",0,"18.289",207040000,34,"0.984044",1,"0.474876","2.85773","tr|E7ESY4|E7ESY4_HUMAN;sp|Q13330|MTA1_HUMAN;tr|H0Y4T7|H0Y4T7_HUMAN;tr|F8VSM3|F8VSM3_HUMAN;tr|F8W9Y9|F8W9Y9_HUMAN","tr|E7ESY4|E7ESY4_HUMAN;sp|Q13330|MTA1_HUMAN;tr|H0Y4T7|H0Y4T7_HUMAN",2237,"E7ESY4","E7ESY4_HUMAN",null,null,"MTA1"]
["26.1981","21.9317","23.6399","23.5411",{"$nulls":3},"macroautophagy;mitochondrial outer membrane translocase complex assembly;protein deubiquitination;protein import into mitochondrial matrix;protein targeting to mitochondrion;tRNA import into mitochondrion","mitochondrion targeting sequence binding;P-P-bond-hydrolysis-driven protein transmembrane transporter activity;unfolded protein binding","ER-mitochondrion membrane contact site;extracellular matrix;integral component of mitochondrial outer membrane;mitochondrial outer membrane;mitochondrial outer membrane translocase complex;mitochondrion",{"$nulls":3},3,3,3,"27.6","27.6","27.6","16.298",0,"70.479",3503800000,77,"0.0733038",1,"0.474426","0.222343","sp|Q15388|TOM20_HUMAN","sp|Q15388|TOM20_HUMAN",2481,"Q15388","TOM20_HUMAN","Mitochondrial import receptor subunit TOM20 homolog",null,"TOMM20"]
["23.3407","24.0189","23.5343","22.8778",{"$nulls":3},"glutathione biosynthetic process;release of cytochrome c from mitochondria","gamma-glutamylcyclotransferase activity;lyase activity;protein homodimerization activity","cytosol;extracellular exosome","Glutathione metabolism;Metabolic pathways",null,null,9,9,9,"63.8","63.8","63.8","21.007",0,"213.22",1728100000,71,"0.375491",1,"0.473711","1.00372","sp|O75223|GGCT_HUMAN;tr|M0QZK8|M0QZK8_HUMAN;tr|B8ZZK2|B8ZZK2_HUMAN;tr|H7BZK5|H7BZK5_HUMAN;tr|A0A0B4J1Y4|A0A0B4J1Y4_HUMAN","sp|O75223|GGCT_HUMAN;tr|M0QZK8|M0QZK8_HUMAN;tr|B8ZZK2|B8ZZK2_HUMAN",540,"O75223","GGCT_HUMAN","Gamma-glutamylcyclotransferase",null,"GGCT"]
["20.8048","20.9251","20.0092","20.7735",{"$nulls":3},"negative regulation of transcription elongation from RNA polymerase II promoter;positive regulation of viral transcription;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","RNA binding","cytoplasm;NELF complex;nucleoplasm",{"$nulls":3},8,8,8,"20.5","20.5","20.5","65.697",0,"40.898",419460000,24,"0.46155",1,"0.473566","1.22424","sp|Q8WX92|NELFB_HUMAN","sp|Q8WX92|NELFB_HUMAN",3460,"Q8WX92","NELFB_HUMAN","Negative elongation factor B","ELF-B","NELFB"]
["20.5497","20.6058","20.6291","19.5818",{"$nulls":3},"adherens junction assembly;bicellular tight junction assembly;cell morphogenesis involved in neuron differentiation;mitotic cell cycle;negative regulation of cell-substrate adhesion;negative regulation of microtubule polymerization;post-chaperonin tubulin folding pathway;protein folding;tubulin complex assembly","beta-tubulin binding;chaperone binding;GTPase activator activity","adherens junction;bicellular tight junction;centrosome;cytoplasm;lateral plasma membrane;microtubule",{"$nulls":3},19,19,19,27,27,27,"132.6",0,"112.99",709480000,43,"0.334617",1,"0.472324","0.900744","sp|Q9BTW9|TBCD_HUMAN;tr|J3KR97|J3KR97_HUMAN;tr|A0A0J9YWI5|A0A0J9YWI5_HUMAN;tr|A0A0J9YVR1|A0A0J9YVR1_HUMAN;tr|I3L439|I3L439_HUMAN;tr|I3L0V3|I3L0V3_HUMAN;tr|I3L163|I3L163_HUMAN;tr|I3L4D2|I3L4D2_HUMAN;tr|I3L3H4|I3L3H4_HUMAN;tr|I3L131|I3L131_HUMAN;tr|I3L143|I3L143_HUMAN;tr|I3L500|I3L500_HUMAN;tr|A0A0J9YVU1|A0A0J9YVU1_HUMAN;tr|I3L1S3|I3L1S3_HUMAN;tr|I3L120|I3L120_HUMAN;tr|A0A0J9YXU4|A0A0J9YXU4_HUMAN;tr|A0A0J9YYG2|A0A0J9YYG2_HUMAN;tr|A0A0G2JME7|A0A0G2JME7_HUMAN","sp|Q9BTW9|TBCD_HUMAN;tr|J3KR97|J3KR97_HUMAN",3973,"Q9BTW9","TBCD_HUMAN","Tubulin-specific chaperone D",null,"TBCD"]
["15.2813","16.1761","15.8237","14.6894",{"$nulls":3},"cellular respiration;mitochondrial RNA processing;mRNA processing","protein kinase activity;RNA binding;rRNA binding","mitochondrial nucleoid;mitochondrion;ribonucleoprotein granule",{"$nulls":3},3,3,3,"4.5","4.5","4.5","86.573","0.0013086","3.8252",33610000,6,"0.23621",1,"0.472123","0.653579","sp|Q7L8L6|FAKD5_HUMAN","sp|Q7L8L6|FAKD5_HUMAN",2976,"Q7L8L6","FAKD5_HUMAN","FAST kinase domain-containing protein 5, mitochondrial",null,"FASTKD5"]
["17.3972","19.6733","17.7574","18.3692",{"$nulls":3},"cell cycle arrest;cell proliferation;cellular response to DNA damage stimulus;ERBB2 signaling pathway;G1/S transition of mitotic cell cycle;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;post-translational protein modification;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;viral process","calcium channel activity;receptor activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","Cul4-RING E3 ubiquitin ligase complex;Cul5-RING ubiquitin ligase complex;cytosol","Human immunodeficiency virus 1 infection;Ubiquitin mediated proteolysis",null,null,8,8,8,"14.1","14.1","14.1","90.954",0,"80.296",132810000,19,"0.138151",1,"0.471939","0.400488","sp|Q93034|CUL5_HUMAN","sp|Q93034|CUL5_HUMAN",3566,"Q93034","CUL5_HUMAN","Cullin-5","UL-5","CUL5"]
["21.5718","22.0525","21.6387","21.042",{"$nulls":4},"cadherin binding;structural molecule activity","basement membrane;extracellular exosome",{"$nulls":3},21,21,21,"43.1","43.1","43.1","57.13",0,"96.545",1635200000,158,"0.464304",1,"0.471782","1.23141","sp|O00515|LAD1_HUMAN;tr|E9PDI4|E9PDI4_HUMAN;tr|A0A0J9YYF6|A0A0J9YYF6_HUMAN;tr|A0A0J9YW63|A0A0J9YW63_HUMAN;tr|A0A0J9YVY2|A0A0J9YVY2_HUMAN;tr|H0Y901|H0Y901_HUMAN","sp|O00515|LAD1_HUMAN;tr|E9PDI4|E9PDI4_HUMAN;tr|A0A0J9YYF6|A0A0J9YYF6_HUMAN;tr|A0A0J9YW63|A0A0J9YW63_HUMAN",238,"O00515","LAD1_HUMAN","Ladinin-1","ad-1","LAD1"]
["18.0279","16.3244","18.0303","15.3789",{"$nulls":3},"activation of JUN kinase activity;activation of MAPKK activity;cell cycle arrest;cell cycle checkpoint;cell death;cell differentiation;cell proliferation;cytoskeleton organization;DNA damage checkpoint;embryonic digit morphogenesis;intracellular signal transduction;limb development;positive regulation of apoptotic process;protein phosphorylation;response to radiation;response to stress","ATP binding;magnesium ion binding;MAP kinase kinase kinase activity;protein serine/threonine kinase activity;RNA binding","cytoplasm;cytosol;nucleus","MAPK signaling pathway",null,null,4,4,3,"7.4","7.4","5.1","91.154",0,"8.5424",62380000,4,"0.100743",1,"0.471566","0.299269","sp|Q9NYL2|MLTK_HUMAN","sp|Q9NYL2|MLTK_HUMAN",4569,"Q9NYL2","M3K20_HUMAN","Mitogen-activated protein kinase kinase kinase 20 {ECO:0000312|HGNC:HGNC:17797}",null,"MAP3K20"]
["19.0908","19.0252","19.3822","17.7912",{"$nulls":3},"defense response to virus;exocyst localization;exocytosis;Golgi to plasma membrane transport;phosphatidylinositol-mediated signaling;positive regulation of protein secretion;protein transport;regulation of macroautophagy;viral process","GTP-Rho binding;phosphatidylinositol-4,5-bisphosphate binding","cytoplasm;cytoplasmic side of apical plasma membrane;cytosol;exocyst;Flemming body;membrane;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},26,26,26,"38.7","38.7","38.7","101.98",0,"161.87",1975100000,183,"0.21192",1,"0.471312","0.591972","sp|Q9NV70|EXOC1_HUMAN","sp|Q9NV70|EXOC1_HUMAN",4480,"Q9NV70","EXOC1_HUMAN","Exocyst complex component 1",null,"EXOC1"]
["22.6393","22.8472","22.94","21.6049",{"$nulls":3},"learning;locomotory behavior;negative regulation of Arp2/3 complex-mediated actin nucleation;nervous system development;protein phosphorylation;signal transduction","actin binding;Arp2/3 complex binding;enzyme activator activity;growth factor activity;protein kinase inhibitor activity;signal transducer activity","intracellular",{"$nulls":3},8,8,8,"45.8","45.8","45.8","16.713",0,"43.191",427250000,30,"0.253364",1,"0.470778","0.696842","sp|P60983|GMFB_HUMAN;tr|G3V4P8|G3V4P8_HUMAN;tr|M0QYG8|M0QYG8_HUMAN;tr|M0R1D2|M0R1D2_HUMAN;tr|M0R0C1|M0R0C1_HUMAN;tr|M0QYJ8|M0QYJ8_HUMAN;sp|O60234|GMFG_HUMAN","sp|P60983|GMFB_HUMAN;tr|G3V4P8|G3V4P8_HUMAN",1819,"P60983","GMFB_HUMAN","Glia maturation factor beta","MF-beta","GMFB"]
["20.4739","20.4374","20.7037","19.2664",{"$nulls":3},"negative regulation of adiponectin secretion;protein transport;regulated exocytosis","Rab GTPase binding","cytoplasm;cytosol;intracellular membrane-bounded organelle;phagocytic vesicle membrane;recycling endosome","Endocytosis",null,null,43,43,41,"50.4","50.4","48.4","137.17",0,"323.31",8016600000,495,"0.236602",1,"0.470558","0.654571","sp|Q6WKZ4|RFIP1_HUMAN;tr|E7EX40|E7EX40_HUMAN","sp|Q6WKZ4|RFIP1_HUMAN;tr|E7EX40|E7EX40_HUMAN",2920,"Q6WKZ4","RFIP1_HUMAN","Rab11 family-interacting protein 1","ab11-FIP1","RAB11FIP1"]
["17.1698","18.5004","18.1908","16.5408",{"$nulls":3},"cellular response to ionizing radiation;DNA damage checkpoint;snRNA 3'-end processing;snRNA processing;snRNA transcription from RNA polymerase II promoter","lipid transporter activity","chromosome;cytoplasm;cytosol;integrator complex;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"3.5","3.5","3.5","106.83","0.0019165","3.4678",954150000,23,"0.154155",1,"0.469287","0.442788","sp|Q9NVH2|INT7_HUMAN;tr|A0A087WXK3|A0A087WXK3_HUMAN","sp|Q9NVH2|INT7_HUMAN",4490,"Q9NVH2","INT7_HUMAN","Integrator complex subunit 7","nt7","INTS7"]
["18.5931","15.2077","17.798","15.0652",{"$nulls":3},"glutaminyl-tRNAGln biosynthesis via transamidation;mitochondrial translation;regulation of protein stability","amidase activity;ATP binding;glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity","glutamyl-tRNA(Gln) amidotransferase complex;mitochondrion","Aminoacyl-tRNA biosynthesis;Metabolic pathways",null,null,6,6,6,"25.6","25.6","25.6","57.46",0,"13.313",47881000,16,"0.0709132",1,"0.46881","0.215511","sp|Q9H0R6|GATA_HUMAN;tr|X6R772|X6R772_HUMAN","sp|Q9H0R6|GATA_HUMAN;tr|X6R772|X6R772_HUMAN",4142,"Q9H0R6","GATA_HUMAN","Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03150}","lu-AdT subunit A {ECO:0000255|HAMAP-Rule:MF_03150}","QRSL1"]
["17.9678",1,"17.0301",1,{"$nulls":3},"ion transport;neutrophil degranulation","nucleic acid binding","extracellular exosome;integral component of membrane;intracellular membrane-bounded organelle;lysosomal membrane;microtubule organizing center;plasma membrane;specific granule membrane;tertiary granule membrane",{"$nulls":3},3,3,3,9,9,9,"92.125","0.0052251","2.7043",29528000,5,"0.0125086",1,"0.468803","0.0401674","sp|O94886|CSCL1_HUMAN;tr|X6RI56|X6RI56_HUMAN","sp|O94886|CSCL1_HUMAN",664,"O94886","CSCL1_HUMAN","CSC1-like protein 1",null,"TMEM63A"]
["22.1771","22.4167","22.4905","21.1664",{"$nulls":3},"cation transmembrane transport;magnesium ion transport","inorganic cation transmembrane transporter activity;magnesium ion transmembrane transporter activity","early endosome;early endosome membrane;ER membrane protein complex;Golgi apparatus;Golgi membrane;integral component of membrane;membrane;plasma membrane",{"$nulls":3},1,1,1,"18.3","18.3","18.3","14.686",0,"12.995",255000000,26,"0.253152",1,"0.468465","0.696309","sp|Q8N4V1|MMGT1_HUMAN","sp|Q8N4V1|MMGT1_HUMAN",3230,"Q8N4V1","MMGT1_HUMAN","Membrane magnesium transporter 1",null,"MMGT1"]
[1,"17.1477",1,"16.2117",{"$nulls":4},"ATP binding","extracellular exosome",{"$nulls":3},2,2,2,"4.3","4.3","4.3","74.977","0.00023507","5.0549",13729000,5,"0.0131479",1,"0.467992","0.0421913","sp|O43301|HS12A_HUMAN;tr|K7ELE6|K7ELE6_HUMAN","sp|O43301|HS12A_HUMAN;tr|K7ELE6|K7ELE6_HUMAN",389,"O43301","HS12A_HUMAN","Heat shock 70 kDa protein 12A",null,"HSPA12A"]
["25.7869","25.5965","26.0823","24.3655",{"$nulls":3},"in utero embryonic development;protein transport;regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter","RNA binding","cytosol;nucleus",{"$nulls":3},10,10,10,"66.5","66.5","66.5","22.168",0,"323.31",12653000000,325,"0.192264",1,"0.467833","0.54171","sp|P20290|BTF3_HUMAN;tr|D6RDG3|D6RDG3_HUMAN;tr|H0Y9Y1|H0Y9Y1_HUMAN","sp|P20290|BTF3_HUMAN;tr|D6RDG3|D6RDG3_HUMAN",1146,"P20290","BTF3_HUMAN","Transcription factor BTF3",null,"BTF3"]
["20.4515","20.8421","20.1412","20.2179",{"$nulls":3},"rRNA processing;tRNA 5'-leader removal","ribonuclease P activity;RNA binding","multimeric ribonuclease P complex;nucleoplasm;nucleus","RNA transport",null,null,3,3,3,"36.3","36.3","36.3","13.693",0,"18.552",128800000,10,"0.843433",1,"0.467297","2.34773","sp|O95059|RPP14_HUMAN","sp|O95059|RPP14_HUMAN",685,"O95059","RPP14_HUMAN","Ribonuclease P protein subunit p14",null,"RPP14"]
["21.7454","22.1821","22.0322","20.9613",{"$nulls":4},"SH3 domain binding;structural constituent of cytoskeleton","cytoskeleton;cytosol","Pathways in cancer;Thyroid cancer",null,null,15,15,15,"39.5","39.5","39.5","53.29",0,"95.558",774760000,60,"0.297475",1,"0.466974","0.807584","sp|Q16204|CCDC6_HUMAN","sp|Q16204|CCDC6_HUMAN",2538,"Q16204","CCDC6_HUMAN","Coiled-coil domain-containing protein 6",null,"CCDC6"]
["19.6895","19.5633","19.776","18.5433",{"$nulls":3},"cellular protein modification process;protein transport",null,"cytosol;nucleolus;plasma membrane",{"$nulls":3},3,3,3,"12.6","12.6","12.6","40.917",0,"16.932",112040000,10,"0.275822",1,"0.466704","0.753283","tr|F5H442|F5H442_HUMAN;sp|Q99816|TS101_HUMAN","tr|F5H442|F5H442_HUMAN;sp|Q99816|TS101_HUMAN",3887,"F5H442","F5H442_HUMAN",null,null,"TSG101"]
["21.8658","23.1526","21.917","22.1752",{"$nulls":3},"autophagic cell death;establishment of protein localization to organelle;Golgi to lysosome transport;granzyme-mediated apoptotic signaling pathway;neutrophil degranulation;positive regulation of natural killer cell degranulation;positive regulation of natural killer cell mediated cytotoxicity;protein stabilization;regulation of organelle transport along microtubule","enzyme binding;protein domain specific binding;virus receptor activity","alveolar lamellar body;autolysosome;azurophil granule membrane;cytolytic granule;cytoplasm;cytosol;dendrite;endosome membrane;external side of plasma membrane;extracellular exosome;ficolin-1-rich granule membrane;integral component of plasma membrane;late endosome;lysosomal membrane;lysosome;melanosome;membrane;multivesicular body;neuronal cell body;perinuclear region of cytoplasm;phagolysosome membrane;plasma membrane;sarcolemma;synaptic vesicle","Autophagy - animal;Lysosome;Phagosome;Tuberculosis",null,null,8,8,8,"16.5","16.5","16.5","44.882",0,"39.15",944540000,31,"0.256884",1,"0.463096","0.705701","sp|P11279|LAMP1_HUMAN","sp|P11279|LAMP1_HUMAN",993,"P11279","LAMP1_HUMAN","Lysosome-associated membrane glycoprotein 1","AMP-1;ysosome-associated membrane protein 1","LAMP1"]
["16.7993","16.3625","15.687","16.5487",{"$nulls":3},"endosome organization;neutrophil degranulation;osteoblast differentiation;protein transport;receptor-mediated endocytosis;regulation of early endosome to late endosome transport;regulation of early endosome to recycling endosome transport",null,"azurophil granule membrane;cytosol;early endosome membrane;endosome membrane;extracellular exosome;intracellular membrane-bounded organelle;lysosomal membrane;membrane;plasma membrane;secretory granule membrane",{"$nulls":3},7,7,7,"4.8","4.8","4.8","254.41",0,"16.349",71968000,12,"0.357612",1,"0.463027","0.958587","sp|O75165|DJC13_HUMAN;tr|H0YA63|H0YA63_HUMAN;tr|H0Y8Q2|H0Y8Q2_HUMAN","sp|O75165|DJC13_HUMAN",532,"O75165","DJC13_HUMAN","DnaJ homolog subfamily C member 13",null,"DNAJC13"]
["24.4378","25.1603","23.7374","24.9385",{"$nulls":3},"neutrophil degranulation;plasma membrane to endosome transport;protein transport;regulation of endocytosis","GDP binding;GTP binding;GTPase activity","anchored component of synaptic vesicle membrane;azurophil granule membrane;early endosome;early endosome membrane;endocytic vesicle;extracellular exosome;lipid droplet;lysosomal membrane;melanosome;plasma membrane","Amoebiasis;Endocytosis;Phagosome;Ras signaling pathway;Tuberculosis;Vasopressin-regulated water reabsorption",null,null,10,10,5,"59.3","59.3","29.2","23.482",0,"134.7",2561700000,106,"0.237929",1,"0.461098","0.657923","sp|P51148|RAB5C_HUMAN;tr|K7ENY4|K7ENY4_HUMAN;tr|K7ERI8|K7ERI8_HUMAN;tr|F8VVK3|F8VVK3_HUMAN;tr|F8VVZ0|F8VVZ0_HUMAN;tr|F8VWU4|F8VWU4_HUMAN;tr|K7EIP6|K7EIP6_HUMAN;tr|F8WCY6|F8WCY6_HUMAN;tr|F8WD79|F8WD79_HUMAN;tr|F8VPW9|F8VPW9_HUMAN;tr|F8VSF8|F8VSF8_HUMAN;tr|F8VWZ7|F8VWZ7_HUMAN","sp|P51148|RAB5C_HUMAN;tr|K7ENY4|K7ENY4_HUMAN;tr|K7ERI8|K7ERI8_HUMAN",1643,"P51148","RAB5C_HUMAN","Ras-related protein Rab-5C",null,"RAB5C"]
["21.305","20.3293","20.5575","20.1547",{"$nulls":3},"establishment of integrated proviral latency;mRNA 5'-splice site recognition;nuclear transport;positive regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;response to heat;response to oxidative stress;transcription, DNA-templated","activating transcription factor binding;chromatin binding;RNA binding;RNA polymerase II transcription coactivator activity;supercoiled DNA binding","cytosol;nuclear heterochromatin;nuclear periphery;nucleoplasm;nucleus;transcriptionally active chromatin",{"$nulls":3},19,19,18,"42.6","42.6","41.1","60.103",0,"204.15",2193400000,214,"0.323752",1,"0.461023","0.873472","sp|O75475|PSIP1_HUMAN;tr|H3BPQ6|H3BPQ6_HUMAN;tr|A0A024R216|A0A024R216_HUMAN;sp|Q9Y3E1|HDGR3_HUMAN","sp|O75475|PSIP1_HUMAN",576,"O75475","PSIP1_HUMAN","PC4 and SFRS1-interacting protein",null,"PSIP1"]
["16.9777","16.7129","16.4584","16.3103",{"$nulls":3},"cilium assembly;microtubule anchoring at centrosome;protein localization to centrosome",null,"centrosome;cytosol;nuclear membrane",{"$nulls":3},17,17,1,"11.1","11.1","0.9","227.73",0,"37.734",311000000,59,"1.02966",1,"0.460945","3.0383","tr|E7ETA6|E7ETA6_HUMAN","tr|E7ETA6|E7ETA6_HUMAN",5201,"E7ETA6","E7ETA6_HUMAN",null,null,"PCM1"]
["18.8754","19.4811","19.3023","18.1332",{"$nulls":3},"regulation of cell growth","opioid receptor activity","cytoplasm;membrane;nucleus",{"$nulls":3},8,8,8,"21.3","21.3","21.3","73.324",0,"31.084",148220000,35,"0.254427",1,"0.460523","0.699517","sp|Q9NZT2|OGFR_HUMAN;tr|A0A0A0MRN5|A0A0A0MRN5_HUMAN;tr|A0A087X028|A0A087X028_HUMAN","sp|Q9NZT2|OGFR_HUMAN;tr|A0A0A0MRN5|A0A0A0MRN5_HUMAN",4604,"Q9NZT2","OGFR_HUMAN","Opioid growth factor receptor","GFr","OGFR"]
["21.0705","22.2026","21.1569","21.1957",{"$nulls":4},"transferase activity, transferring glycosyl groups",{"$nulls":4},4,4,4,"25.9","25.9","25.9","21.51",0,"40.725",223070000,15,"0.299474",1,"0.460249","0.812596","tr|G5E9W8|G5E9W8_HUMAN;tr|C9JQ42|C9JQ42_HUMAN;sp|P46976|GLYG_HUMAN;tr|C9J8R8|C9J8R8_HUMAN;tr|C9J7C7|C9J7C7_HUMAN","tr|G5E9W8|G5E9W8_HUMAN;tr|C9JQ42|C9JQ42_HUMAN;sp|P46976|GLYG_HUMAN",1523,"G5E9W8","G5E9W8_HUMAN"]
["18.1009","19.0213","17.9229","18.2793",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intra-Golgi vesicle-mediated transport;protein transport",null,"cytosol;Golgi apparatus;Golgi membrane;Golgi transport complex;membrane;nucleoplasm;trans-Golgi network membrane",{"$nulls":3},6,6,6,"9.5","9.5","9.5","92.742",0,"13.125",167710000,17,"0.347109",1,"0.459983","0.932143","sp|Q9UP83|COG5_HUMAN","sp|Q9UP83|COG5_HUMAN",4860,"Q9UP83","COG5_HUMAN","Conserved oligomeric Golgi complex subunit 5","OG complex subunit 5","COG5"]
["20.5036","19.1073","18.9721","19.7189",{"$nulls":3},"ATP-dependent chromatin remodeling;behavioral response to ethanol;blood coagulation;cardiac muscle hypertrophy;cellular response to dopamine;cellular response to heat;cellular response to hydrogen peroxide;cellular response to retinoic acid;cellular response to transforming growth factor beta stimulus;chromatin remodeling;circadian regulation of gene expression;dendrite development;embryonic digit morphogenesis;epidermal cell differentiation;eyelid development in camera-type eye;fungiform papilla formation;hair follicle placode formation;histone deacetylation;histone H3 deacetylation;histone H4 deacetylation;maintenance of chromatin silencing;negative regulation of apoptotic process;negative regulation of dendritic spine development;negative regulation of DNA binding;negative regulation of DNA binding transcription factor activity;negative regulation of MHC class II biosynthetic process;negative regulation of neuron projection development;negative regulation of peptidyl-lysine acetylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;odontogenesis of dentin-containing tooth;positive regulation of cell proliferation;positive regulation of collagen biosynthetic process;positive regulation of epithelial to mesenchymal transition;positive regulation of interleukin-1 production;positive regulation of oligodendrocyte differentiation;positive regulation of proteolysis;positive regulation of receptor biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of tumor necrosis factor production;positive regulation of tyrosine phosphorylation of STAT protein;regulation of signal transduction by p53 class mediator;response to amphetamine;response to caffeine;response to cocaine;response to drug;response to hyperoxia;response to lipopolysaccharide;response to nicotine;transcription, DNA-templated","chromatin binding;core promoter binding;deacetylase activity;enzyme binding;heat shock protein binding;histone deacetylase activity;histone deacetylase binding;NAD-dependent histone deacetylase activity (H3-K14 specific);NF-kappaB binding;protein deacetylase activity;RNA binding;RNA polymerase II repressing transcription factor binding;sequence-specific DNA binding;transcription factor binding","cytoplasm;ESC/E(Z) complex;nuclear chromatin;nucleoplasm;nucleus;NuRD complex;protein complex;Sin3 complex","Alcoholism;Cell cycle;Chronic myeloid leukemia;Epstein-Barr virus infection;Human papillomavirus infection;Huntington disease;Longevity regulating pathway - multiple species;Notch signaling pathway;Pathways in cancer;Thyroid hormone signaling pathway;Transcriptional misregulation in cancer;Viral carcinogenesis",null,null,10,6,6,"23.4","14.5","14.5","55.364",0,"35.53",311780000,32,"0.207581",1,"0.45993","0.580913","sp|Q92769|HDAC2_HUMAN;tr|E5RFI6|E5RFI6_HUMAN;tr|E5RJ04|E5RJ04_HUMAN;tr|E5RGV4|E5RGV4_HUMAN;tr|E5RHE7|E5RHE7_HUMAN;tr|E5RH52|E5RH52_HUMAN;tr|E5RG37|E5RG37_HUMAN;tr|E5RFP9|E5RFP9_HUMAN;tr|H3BM24|H3BM24_HUMAN;tr|E5RK19|E5RK19_HUMAN","sp|Q92769|HDAC2_HUMAN",3527,"Q92769","HDAC2_HUMAN","Histone deacetylase 2","D2","HDAC2"]
["18.7454","18.2644","16.9488","19.1411",{"$nulls":3},"DNA dealkylation involved in DNA repair;regulation of transcription, DNA-templated;transcription, DNA-templated",null,"activating signal cointegrator 1 complex;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"12.9","12.9","12.9","86.359",0,"14.899",93129000,19,"0.141671",1,"0.45993","0.409837","sp|Q9H1I8|ASCC2_HUMAN;tr|B1AH59|B1AH59_HUMAN","sp|Q9H1I8|ASCC2_HUMAN",4157,"Q9H1I8","ASCC2_HUMAN","Activating signal cointegrator 1 complex subunit 2",null,"ASCC2"]
["18.6717","18.9543","19.1016","17.6048",{"$nulls":3},"cell division;cell proliferation;cerebral cortex development;metaphase/anaphase transition of mitotic cell cycle;microtubule cytoskeleton organization involved in mitosis;regulation of mitotic spindle organization",null,"cytoplasm;microtubule cytoskeleton;microtubule organizing center;spindle pole","RNA transport",null,null,8,8,8,"15.9","15.9","15.9","90.359",0,"15.474",120650000,20,"0.21655",1,"0.459826","0.603754","sp|Q9Y6A5|TACC3_HUMAN;tr|C9JWI7|C9JWI7_HUMAN;tr|Q8IX09|Q8IX09_HUMAN;tr|H0Y8F2|H0Y8F2_HUMAN;tr|E7EMT0|E7EMT0_HUMAN;tr|C9JA91|C9JA91_HUMAN","sp|Q9Y6A5|TACC3_HUMAN",5084,"Q9Y6A5","TACC3_HUMAN","Transforming acidic coiled-coil-containing protein 3",null,"TACC3"]
["19.1405","19.7357","18.7954","19.1649",{"$nulls":3},"alternative mRNA splicing, via spliceosome;blood coagulation;cellular response to cAMP;cellular response to gamma radiation;cellular response to UV;cerebral cortex development;guanine metabolic process;histone H3-K4 demethylation;histone H3-K9 demethylation;muscle cell development;negative regulation of DNA binding;negative regulation of DNA binding transcription factor activity;negative regulation of DNA damage response, signal transduction by p53 class mediator;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;negative regulation of protein binding;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;neuron maturation;positive regulation of cell size;positive regulation of chromatin binding;positive regulation of DNA binding transcription factor activity;positive regulation of histone ubiquitination;positive regulation of neuron projection development;positive regulation of transcription from RNA polymerase II promoter;protein demethylation;regulation of cellular protein localization;regulation of double-strand break repair via homologous recombination;regulation of transcription from RNA polymerase II promoter;response to fungicide;transcription, DNA-templated","androgen receptor binding;chromatin binding;demethylase activity;enzyme binding;flavin adenine dinucleotide binding;histone deacetylase activity;histone demethylase activity;histone demethylase activity (H3-dimethyl-K4 specific);histone demethylase activity (H3-K4 specific);histone demethylase activity (H3-K9 specific);ligand-dependent nuclear receptor transcription coactivator activity;MRF binding;oxidoreductase activity;p53 binding;telomeric DNA binding;telomeric repeat-containing RNA binding;transcription factor binding;transcription regulatory region DNA binding","DNA repair complex;nuclear chromatin;nuclear chromosome, telomeric region;nucleoplasm;nucleus;protein complex;transcription factor complex","Thermogenesis",null,null,12,12,12,"31.8","31.8","31.8","92.902",0,"45.636",228780000,32,"0.493196",1,"0.457894","1.30721","sp|O60341|KDM1A_HUMAN;tr|R4GMP9|R4GMP9_HUMAN;tr|R4GMQ1|R4GMQ1_HUMAN","sp|O60341|KDM1A_HUMAN;tr|R4GMP9|R4GMP9_HUMAN",467,"O60341","KDM1A_HUMAN","Lysine-specific histone demethylase 1A",null,"KDM1A"]
["17.4108",1,"16.496",1,{"$nulls":9},6,6,6,"35.5","35.5","35.5","13.303",0,"17.149",121850000,8,"0.0126236",1,"0.457417","0.0405319","tr|A0A087WYP2|A0A087WYP2_HUMAN;sp|Q8IZQ5|SELH_HUMAN;tr|H0YE28|H0YE28_HUMAN;tr|H3BV83|H3BV83_HUMAN","tr|A0A087WYP2|A0A087WYP2_HUMAN;sp|Q8IZQ5|SELH_HUMAN;tr|H0YE28|H0YE28_HUMAN",3181,"A0A087WYP2","A0A087WYP2_HUMAN",null,null,"SELENOH"]
["21.656","21.5405","21.1775","21.1042",{"$nulls":3},"DNA repair;DNA replication;DNA replication-independent nucleosome organization;nucleosome disassembly;positive regulation of DNA-templated transcription, elongation;positive regulation of transcription elongation from RNA polymerase II promoter;regulation of signal transduction by p53 class mediator;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","histone binding;nucleosome binding;RNA binding","chromosome;FACT complex;nucleoplasm;nucleus",{"$nulls":3},35,35,35,"35.4","35.4","35.4","119.91",0,"323.31",4588500000,326,"1.66506",1,"0.457391","6.68952","sp|Q9Y5B9|SP16H_HUMAN","sp|Q9Y5B9|SP16H_HUMAN",5038,"Q9Y5B9","SP16H_HUMAN","FACT complex subunit SPT16",null,"SUPT16H"]
["21.7535","22.9685","22.1456","21.6642",{"$nulls":3},"response to drug;SRP-dependent cotranslational protein targeting to membrane;SRP-dependent cotranslational protein targeting to membrane, translocation","7S RNA binding;RNA binding;signal recognition particle binding;TPR domain binding","cytosol;endoplasmic reticulum;signal recognition particle;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,21,21,21,39,39,39,"74.605",0,177,8986400000,196,"0.253798",1,"0.456062","0.697936","sp|O76094|SRP72_HUMAN;tr|D6RDY6|D6RDY6_HUMAN;tr|R4GNC1|R4GNC1_HUMAN","sp|O76094|SRP72_HUMAN",647,"O76094","SRP72_HUMAN","Signal recognition particle subunit SRP72","RP72","SRP72"]
["22.9352","23.553","22.8872","22.692",{"$nulls":3},"arginine biosynthetic process;argininosuccinate metabolic process;aspartate metabolic process;cellular response to laminar fluid shear stress;circadian rhythm;citrulline metabolic process;negative regulation of leukocyte cell-cell adhesion;positive regulation of nitric oxide biosynthetic process;urea cycle","amino acid binding;argininosuccinate synthase activity;ATP binding;identical protein binding;RNA binding","cytoplasm;cytosol;extracellular exosome;mitochondrion;myelin sheath","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Fluid shear stress and atherosclerosis;Metabolic pathways",null,null,18,18,18,"54.9","54.9","54.9","46.53",0,"199.2",1715800000,96,"0.529162",1,"0.454513","1.40309","sp|P00966|ASSY_HUMAN;tr|Q5T6L6|Q5T6L6_HUMAN;tr|Q5T6L5|Q5T6L5_HUMAN","sp|P00966|ASSY_HUMAN;tr|Q5T6L6|Q5T6L6_HUMAN",810,"P00966","ASSY_HUMAN","Argininosuccinate synthase {ECO:0000305}",null,"ASS1"]
["22.3235","22.5358","22.4806","21.4698",{"$nulls":3},"cell differentiation;cell proliferation;regulation of myeloid cell differentiation;transcription, DNA-templated","mRNA binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;single-stranded DNA binding;SMAD binding;transcription factor binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","DNA replication factor A complex;nucleus",{"$nulls":3},5,5,5,"38.1","38.1","38.1","33.24",0,"71.036",351340000,17,"0.326351",1,"0.454437","0.879993","sp|Q96QR8|PURB_HUMAN","sp|Q96QR8|PURB_HUMAN",3798,"Q96QR8","PURB_HUMAN","Transcriptional activator protein Pur-beta",null,"PURB"]
["22.586","22.9256","22.6836","21.9211",{"$nulls":3},"carnitine biosynthetic process;cellular aldehyde metabolic process;hormone metabolic process;neurotransmitter biosynthetic process;oxidation-reduction process","1-pyrroline dehydrogenase activity;3-chloroallyl aldehyde dehydrogenase activity;4-trimethylammoniobutyraldehyde dehydrogenase activity;aldehyde dehydrogenase (NAD) activity;aminobutyraldehyde dehydrogenase activity","cytoplasm;cytosol;extracellular exosome","Arginine and proline metabolism;Ascorbate and aldarate metabolism;beta-Alanine metabolism;Fatty acid degradation;Glycerolipid metabolism;Glycolysis / Gluconeogenesis;Histidine metabolism;Lysine degradation;Metabolic pathways;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,15,15,15,"33.4","33.4","33.4","53.801",0,"134.56",1236700000,83,"0.408113",1,"0.453468","1.08658","sp|P49189|AL9A1_HUMAN","sp|P49189|AL9A1_HUMAN",1560,"P49189","AL9A1_HUMAN","4-trimethylaminobutyraldehyde dehydrogenase","MABADH","ALDH9A1"]
[1,"18.1706",1,"17.2642",{"$nulls":3},"exocytosis;Golgi ribbon formation;membrane organization;microtubule cytoskeleton organization;SNARE complex assembly","SNAP receptor activity;SNARE binding","cell surface;clathrin-coated vesicle membrane;endosome;Golgi apparatus;Golgi membrane;integral component of synaptic vesicle membrane;lysosome;plasma membrane;SNARE complex;synaptic vesicle;trans-Golgi network membrane;transport vesicle","SNARE interactions in vesicular transport",null,null,1,1,1,"9.9","9.9","9.9","16.397","0.0031263","3.204",9058200,2,"0.011927",1,"0.453192","0.0383239","sp|O75379|VAMP4_HUMAN","sp|O75379|VAMP4_HUMAN",556,"O75379","VAMP4_HUMAN","Vesicle-associated membrane protein 4","AMP-4","VAMP4"]
["21.0748","21.1302","21.2516","20.0471",{"$nulls":3},"apoptotic process;CTP biosynthetic process;GTP biosynthetic process;nucleobase-containing small molecule interconversion;regulation of apoptotic process;UTP biosynthetic process","ATP binding;metal ion binding;nucleoside diphosphate kinase activity","cytosol;extracellular exosome;intracellular;mitochondrion","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,7,7,7,"43.2","43.2","43.2","19.015",0,"15.175",174860000,24,"0.275174",1,"0.453147","0.751657","sp|Q13232|NDK3_HUMAN;tr|H3BPR2|H3BPR2_HUMAN;tr|H3BPD9|H3BPD9_HUMAN;tr|H3BMQ7|H3BMQ7_HUMAN;tr|H3BRA8|H3BRA8_HUMAN","sp|Q13232|NDK3_HUMAN",2224,"Q13232","NDK3_HUMAN","Nucleoside diphosphate kinase 3","DK 3;DP kinase 3","NME3"]
["21.8787","22.1008","22.0917","20.9827",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;RNA splicing;viral process","RNA binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;precatalytic spliceosome;spliceosomal complex;U12-type spliceosomal complex;U2 snRNP;U2-type spliceosomal complex","Spliceosome",null,null,28,28,28,"39.7","39.7","39.7","100.23",0,"166.17",2079800000,192,"0.294558",1,"0.452575","0.800273","sp|Q13435|SF3B2_HUMAN;tr|A0A087WZZ5|A0A087WZZ5_HUMAN;tr|E9PPJ0|E9PPJ0_HUMAN;tr|E9PJ04|E9PJ04_HUMAN;tr|H0YCG1|H0YCG1_HUMAN;tr|E9PJT3|E9PJT3_HUMAN;tr|H0YEX5|H0YEX5_HUMAN;tr|E9PIL8|E9PIL8_HUMAN","sp|Q13435|SF3B2_HUMAN;tr|A0A087WZZ5|A0A087WZZ5_HUMAN;tr|E9PPJ0|E9PPJ0_HUMAN;tr|E9PJ04|E9PJ04_HUMAN",2253,"Q13435","SF3B2_HUMAN","Splicing factor 3B subunit 2",null,"SF3B2"]
["21.2991","21.6086","21.0603","20.9423",{"$nulls":3},"NADPH regeneration;oxidation-reduction process;proton transport;reactive oxygen species metabolic process;tricarboxylic acid cycle","NAD binding;NAD(P)+ transhydrogenase (AB-specific) activity;NAD(P)+ transhydrogenase (B-specific) activity;NAD(P)+ transhydrogenase activity;NADP binding","integral component of membrane;membrane;mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrion","Metabolic pathways;Nicotinate and nicotinamide metabolism",null,null,19,19,19,"20.5","20.5","20.5","113.89",0,"123.13",877440000,53,"0.951176",1,"0.452502","2.73245","sp|Q13423|NNTM_HUMAN;tr|E9PCX7|E9PCX7_HUMAN;tr|D6RHU2|D6RHU2_HUMAN;tr|D6RAI5|D6RAI5_HUMAN;tr|H0Y8P5|H0Y8P5_HUMAN;tr|D6RCR6|D6RCR6_HUMAN","sp|Q13423|NNTM_HUMAN;tr|E9PCX7|E9PCX7_HUMAN",2249,"Q13423","NNTM_HUMAN","NAD(P) transhydrogenase, mitochondrial",null,"NNT"]
["19.1885","20.0374","19.0307","19.2906",{"$nulls":3},"phosphatidylinositol biosynthetic process;regulation of lipid kinase activity;signal transduction;viral process","receptor activity","early endosome membrane;endoplasmic reticulum;endosome membrane;Golgi membrane;late endosome membrane;PAS complex","Human T-cell leukemia virus 1 infection;Viral carcinogenesis",null,null,7,7,7,13,13,13,"87.972",0,"33.763",207700000,25,"0.381512",1,"0.452302","1.01896","sp|Q08AM6|VAC14_HUMAN;tr|H3BUU8|H3BUU8_HUMAN;tr|H3BN23|H3BN23_HUMAN;tr|A0A087WT26|A0A087WT26_HUMAN","sp|Q08AM6|VAC14_HUMAN",2138,"Q08AM6","VAC14_HUMAN","Protein VAC14 homolog",null,"VAC14"]
["17.4802","18.0183","17.5725","17.0214",{"$nulls":3},"actin cytoskeleton reorganization;intracellular signal transduction;protein phosphorylation","ATP binding;magnesium ion binding;protein serine/threonine kinase activity","cell leading edge;cytosol;microtubule organizing center",{"$nulls":3},31,31,30,"25.1","25.1","24.3","172.46",0,"231.87",1183900000,129,"0.442346",1,"0.452302","1.17445","sp|Q6DT37|MRCKG_HUMAN","sp|Q6DT37|MRCKG_HUMAN",2808,"Q6DT37","MRCKG_HUMAN","Serine/threonine-protein kinase MRCK gamma",null,"CDC42BPG"]
["19.7435","16.984","20.0139","15.8111",{"$nulls":3},"centrosome duplication;cytoplasmic microtubule organization;interphase microtubule nucleation by interphase microtubule organizing center;meiotic cell cycle;microtubule nucleation;mitotic spindle assembly;single fertilization","gamma-tubulin binding;structural constituent of cytoskeleton;structural molecule activity","centriole;centrosome;cytoplasm;cytosol;equatorial microtubule organizing center;gamma-tubulin small complex;membrane;polar microtubule;spindle",{"$nulls":3},6,6,6,"9.2","9.2","9.2","103.57",0,"13.423",237550000,19,"0.0584541",1,"0.451293","0.179522","sp|Q96CW5|GCP3_HUMAN;tr|A0A087WWB5|A0A087WWB5_HUMAN;tr|A0A087WU06|A0A087WU06_HUMAN","sp|Q96CW5|GCP3_HUMAN;tr|A0A087WWB5|A0A087WWB5_HUMAN;tr|A0A087WU06|A0A087WU06_HUMAN",3644,"Q96CW5","GCP3_HUMAN","Gamma-tubulin complex component 3","CP-3;GCP3","TUBGCP3"]
["20.2226","14.4737","20.3126","13.4828",{"$nulls":3},"adipose tissue development;chorion development;DNA damage response, signal transduction by p53 class mediator;DNA recombination;double-strand break repair via nonhomologous end joining;endothelial cell migration;histone H3-K4 methylation;positive regulation of histone acetylation;positive regulation of histone H3-K36 methylation;positive regulation of histone H3-K4 methylation;positive regulation of isotype switching;positive regulation of isotype switching to IgG isotypes;positive regulation of protein ubiquitination;positive regulation of response to DNA damage stimulus;positive regulation of transcription initiation from RNA polymerase II promoter;regulation of cell cycle G2/M phase transition;response to ionizing radiation;transcription, DNA-templated;vasculogenesis",null,"chromosome;histone methyltransferase complex;MLL3/4 complex;nuclear matrix;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"2.4","2.4","2.4","121.34","0.0013135","3.8583",174160000,6,"0.0320652",1,"0.450425","0.10091","sp|Q6ZW49|PAXI1_HUMAN;tr|H7BZI8|H7BZI8_HUMAN","sp|Q6ZW49|PAXI1_HUMAN;tr|H7BZI8|H7BZI8_HUMAN",2937,"Q6ZW49","PAXI1_HUMAN","PAX-interacting protein 1",null,"PAXIP1"]
["19.1058","20.8033","19.4874","19.5211",{"$nulls":3},"mRNA processing;RNA splicing","RNA binding","nuclear speck;nucleolus;nucleus",{"$nulls":3},5,5,5,"17.3","17.3","17.3","44.915",0,"46.145",761750000,62,"0.187891",1,"0.450305","0.530467","sp|Q66PJ3|AR6P4_HUMAN;tr|F5GYV5|F5GYV5_HUMAN;tr|H7BZV4|H7BZV4_HUMAN;tr|A0A0C4DG62|A0A0C4DG62_HUMAN;tr|F8WCT1|F8WCT1_HUMAN;tr|F5H7X4|F5H7X4_HUMAN;tr|F8WEP2|F8WEP2_HUMAN;tr|A0A0C4DH18|A0A0C4DH18_HUMAN","sp|Q66PJ3|AR6P4_HUMAN;tr|F5GYV5|F5GYV5_HUMAN;tr|H7BZV4|H7BZV4_HUMAN;tr|A0A0C4DG62|A0A0C4DG62_HUMAN;tr|F8WCT1|F8WCT1_HUMAN;tr|F5H7X4|F5H7X4_HUMAN",2786,"Q66PJ3","AR6P4_HUMAN","ADP-ribosylation factor-like protein 6-interacting protein 4","ip-4;RL-6-interacting protein 4","ARL6IP4"]
["20.7485","20.7704","21.1396","19.4791",{"$nulls":3},"cellular response to extracellular stimulus;cytolysis;defense response to Gram-negative bacterium;defense response to Gram-positive bacterium;inflammatory response;innate immune response;neutrophil degranulation;pore complex assembly;pore formation in membrane of other organism;positive regulation of interleukin-1 beta secretion;protein homooligomerization;pyroptosis","cardiolipin binding;phosphatidic acid binding;phosphatidylinositol-4,5-bisphosphate binding;phosphatidylinositol-4-phosphate binding;phosphatidylserine binding","cytosol;extracellular region;extracellular space;ficolin-1-rich granule lumen;NLRP3 inflammasome complex;nucleoplasm;plasma membrane;specific granule lumen;tertiary granule lumen","NOD-like receptor signaling pathway",null,null,5,5,5,"19.6","19.6","19.6","52.8",0,"46.708",205860000,22,"0.192404",1,"0.450095","0.54207","sp|P57764|GSDMD_HUMAN;tr|G3V1A6|G3V1A6_HUMAN;tr|E9PIB2|E9PIB2_HUMAN;tr|E9PQ48|E9PQ48_HUMAN;tr|E9PNZ0|E9PNZ0_HUMAN;tr|E9PQR9|E9PQR9_HUMAN","sp|P57764|GSDMD_HUMAN;tr|G3V1A6|G3V1A6_HUMAN;tr|E9PIB2|E9PIB2_HUMAN",1797,"P57764","GSDMD_HUMAN","Gasdermin-D",null,"GSDMD"]
["18.6918","15.4266","18.2254","14.9928",{"$nulls":3},"negative regulation of telomere maintenance via telomerase;rRNA acetylation involved in maturation of SSU-rRNA;rRNA modification;tRNA acetylation;tRNA wobble cytosine modification","ATP binding;DNA polymerase binding;N-acetyltransferase activity;RNA binding;rRNA cytidine N-acetyltransferase activity;tRNA binding;tRNA N-acetyltransferase activity","90S preribosome;membrane;midbody;nuclear chromosome, telomeric region;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes",null,null,29,29,29,"36.9","36.9","36.9","115.73",0,"218.49",2237100000,196,"0.0640987",1,"0.450076","0.195908","sp|Q9H0A0|NAT10_HUMAN;tr|A0A087WV29|A0A087WV29_HUMAN;tr|E9PJN6|E9PJN6_HUMAN;tr|E9PMU0|E9PMU0_HUMAN","sp|Q9H0A0|NAT10_HUMAN;tr|A0A087WV29|A0A087WV29_HUMAN",4128,"Q9H0A0","NAT10_HUMAN","RNA cytidine acetyltransferase {ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000305}",null,"NAT10"]
["22.3863","23.1524","22.5146","22.1251",{"$nulls":3},"branched-chain amino acid biosynthetic process;branched-chain amino acid catabolic process;cell proliferation;G1/S transition of mitotic cell cycle;leucine biosynthetic process;valine biosynthetic process","branched-chain-amino-acid transaminase activity;identical protein binding;L-isoleucine transaminase activity;L-leucine transaminase activity;L-valine transaminase activity","cytosol;mitochondrion","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Cysteine and methionine metabolism;Metabolic pathways;Pantothenate and CoA biosynthesis;Valine, leucine and isoleucine biosynthesis;Valine, leucine and isoleucine degradation",null,null,10,10,10,"31.3","31.3","31.3","42.966",0,"55.655",863760000,53,"0.392232",1,"0.449524","1.04615","sp|P54687|BCAT1_HUMAN;tr|F5H2F2|F5H2F2_HUMAN;tr|A0A087WYF2|A0A087WYF2_HUMAN","sp|P54687|BCAT1_HUMAN",1738,"P54687","BCAT1_HUMAN","Branched-chain-amino-acid aminotransferase, cytosolic","CAT(c)","BCAT1"]
["27.6138","26.7819","27.7419","25.7551",{"$nulls":3},"erythrocyte homeostasis;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleoplasm;ribosome","Ribosome",null,null,9,9,9,"62.2","62.2","62.2","15.55",0,"323.31",70278000000,465,"0.144455",1,"0.449323","0.417214","sp|P08708|RS17_HUMAN;tr|H0YN88|H0YN88_HUMAN;tr|A0A075B716|A0A075B716_HUMAN;tr|H0YN73|H0YN73_HUMAN;tr|H3BNC9|H3BNC9_HUMAN","sp|P08708|RS17_HUMAN;tr|H0YN88|H0YN88_HUMAN;tr|A0A075B716|A0A075B716_HUMAN",930,"P08708","RS17_HUMAN","40S ribosomal protein S17 {ECO:0000305}",null,"RPS17"]
["18.7781","19.2566","17.9041","19.2346",{"$nulls":3},"tetrahydrobiopterin biosynthetic process","6-pyruvoyltetrahydropterin synthase activity",{"$nulls":4},1,1,1,"15.6","15.6","15.6","8.9132","0.0029246","3.2336",18555000,6,"0.228381",1,"0.44805","0.633773","tr|E9PNN3|E9PNN3_HUMAN;sp|Q03393|PTPS_HUMAN","tr|E9PNN3|E9PNN3_HUMAN;sp|Q03393|PTPS_HUMAN",2083,"E9PNN3","E9PNN3_HUMAN",null,null,"PTS"]
["20.2946","19.9485","18.3456","21.0026",{"$nulls":3},"cellular response to stimulus;central nervous system development;myelination;oligodendrocyte development;ovarian follicle development;regulation of molecular function;regulation of translational initiation;response to glucose;response to heat;response to peptide hormone;translational initiation","ATP binding;GTP binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex","Herpes simplex virus 1 infection;RNA transport",null,null,6,6,6,"21.9","21.9","21.9","38.989",0,"27.999",272950000,26,"0.113411",1,"0.447433","0.333963","sp|P49770|EI2BB_HUMAN;tr|G3V5E5|G3V5E5_HUMAN;tr|H0YJJ8|H0YJJ8_HUMAN;tr|H0YK01|H0YK01_HUMAN","sp|P49770|EI2BB_HUMAN;tr|G3V5E5|G3V5E5_HUMAN",1600,"P49770","EI2BB_HUMAN","Translation initiation factor eIF-2B subunit beta",null,"EIF2B2"]
["18.2957","19.8372","18.5621","18.6764",{"$nulls":4},"ATP binding","mitochondrion",{"$nulls":3},32,1,0,"53.3","1.7",0,"64.243","0.0013058","3.7879",451720000,11,"0.206694",1,"0.447227","0.578649","tr|H0Y2W2|H0Y2W2_HUMAN","tr|H0Y2W2|H0Y2W2_HUMAN",5246,"H0Y2W2","H0Y2W2_HUMAN",null,null,"ATAD3A"]
["18.94","19.4629","18.9287","18.5805",{"$nulls":3},"cell morphogenesis;cell proliferation;ceramide metabolic process;endoplasmic reticulum organization;ER to Golgi ceramide transport;heart morphogenesis;immune response;in utero embryonic development;intermembrane sphingolipid transfer;lipid homeostasis;mitochondrion morphogenesis;muscle contraction;response to endoplasmic reticulum stress;signal transduction;sphingolipid biosynthetic process","ceramide binding;intermembrane ceramide transfer activity;kinase activity;phosphatidylinositol-4-phosphate binding","cytosol;endoplasmic reticulum membrane;Golgi apparatus;intracellular;mitochondrion;nucleoplasm",{"$nulls":3},6,6,6,13,13,13,"70.834",0,"18.669",160260000,19,"0.536369",1,"0.446849","1.42253","sp|Q9Y5P4|C43BP_HUMAN;tr|H0Y9J1|H0Y9J1_HUMAN;tr|A0A0A0MRE4|A0A0A0MRE4_HUMAN","sp|Q9Y5P4|C43BP_HUMAN;tr|H0Y9J1|H0Y9J1_HUMAN;tr|A0A0A0MRE4|A0A0A0MRE4_HUMAN",5049,"Q9Y5P4","C43BP_HUMAN","Collagen type IV alpha-3-binding protein",null,"COL4A3BP"]
["20.7061","20.4983","20.7813","19.531",{"$nulls":3},"nucleotide metabolic process;pyrimidine nucleoside salvage","hydrolase activity;metal ion binding;phosphatase activity;pseudouridine 5'-phosphatase activity","cytoplasm;cytosol;extracellular exosome",{"$nulls":3},4,4,4,32,32,32,"25.249",0,"22.343",134230000,17,"0.256143",1,"0.446058","0.703836","sp|Q08623|HDHD1_HUMAN;tr|E7EVH9|E7EVH9_HUMAN","sp|Q08623|HDHD1_HUMAN;tr|E7EVH9|E7EVH9_HUMAN",2133,"Q08623","HDHD1_HUMAN","Pseudouridine-5'-phosphatase {ECO:0000312|HGNC:HGNC:16818}",null,"PUDP"]
["19.6832","18.9839","19.0386","18.7376",{"$nulls":3},"2-oxoglutarate metabolic process;cellular amino acid biosynthetic process;L-alanine catabolic process;L-alanine metabolic process","L-alanine:2-oxoglutarate aminotransferase activity;pyridoxal phosphate binding","mitochondrial matrix","2-Oxocarboxylic acid metabolism;Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways",null,null,8,8,8,"19.5","19.5","19.5","57.903",0,"39.939",144930000,18,"0.44068",1,"0.445426","1.17014","sp|Q8TD30|ALAT2_HUMAN;tr|H3BU54|H3BU54_HUMAN","sp|Q8TD30|ALAT2_HUMAN",3383,"Q8TD30","ALAT2_HUMAN","Alanine aminotransferase 2","LT2","GPT2"]
["16.8665",1,"15.9764",1,{"$nulls":3},"signal transduction","GTPase activator activity","cytosol;intracellular membrane-bounded organelle;nucleoplasm;plasma membrane",{"$nulls":3},5,5,5,"5.9","5.9","5.9","134.64","0.00025387","6.6908",84851000,6,"0.0127074",1,"0.445061","0.040797","tr|E7EU13|E7EU13_HUMAN;sp|Q96P48|ARAP1_HUMAN;tr|A0A0A0MSJ2|A0A0A0MSJ2_HUMAN;tr|F8WBT0|F8WBT0_HUMAN;tr|H0YGD1|H0YGD1_HUMAN;tr|F5GWQ2|F5GWQ2_HUMAN;tr|F5GWN4|F5GWN4_HUMAN","tr|E7EU13|E7EU13_HUMAN;sp|Q96P48|ARAP1_HUMAN;tr|A0A0A0MSJ2|A0A0A0MSJ2_HUMAN",3783,"E7EU13","E7EU13_HUMAN",null,null,"ARAP1"]
["21.4506","22.0198","21.85","20.7314",{"$nulls":3},"cell differentiation;cell redox homeostasis;negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway","peptide disulfide oxidoreductase activity;protein-disulfide reductase (glutathione) activity","endoplasmic reticulum lumen","Glutathione metabolism;Metabolic pathways",null,null,5,5,5,"37.2","37.2","37.2","19.206",0,"13.145",231880000,25,"0.257932",1,"0.444512","0.708338","sp|O95881|TXD12_HUMAN","sp|O95881|TXD12_HUMAN",777,"O95881","TXD12_HUMAN","Thioredoxin domain-containing protein 12",null,"TXNDC12"]
["19.0924","18.8339","18.7153","18.3243",{"$nulls":3},"mRNA 3'-end processing;mRNA polyadenylation;mRNA splicing, via spliceosome;regulation of mRNA 3'-end processing;RNA polyadenylation;termination of RNA polymerase II transcription","ATP binding;magnesium ion binding;manganese ion binding;polynucleotide adenylyltransferase activity;RNA binding","cytoplasm;nucleoplasm;nucleus","mRNA surveillance pathway",null,null,8,8,8,"15.8","15.8","15.8","82.842",0,"16.855",140850000,28,"0.700896",1,"0.443324","1.89143","sp|P51003|PAPOA_HUMAN;tr|G3XAH6|G3XAH6_HUMAN;tr|A0A0C4DGK1|A0A0C4DGK1_HUMAN;tr|G3V457|G3V457_HUMAN;tr|G3V3I9|G3V3I9_HUMAN;tr|G3V2A0|G3V2A0_HUMAN;tr|H0YJL4|H0YJL4_HUMAN;tr|H0YJ00|H0YJ00_HUMAN;sp|Q9NRJ5|PAPOB_HUMAN","sp|P51003|PAPOA_HUMAN;tr|G3XAH6|G3XAH6_HUMAN;tr|A0A0C4DGK1|A0A0C4DGK1_HUMAN",1641,"P51003","PAPOA_HUMAN","Poly(A) polymerase alpha","AP-alpha","PAPOLA"]
["22.5458","23.3392","22.4747","22.524",{"$nulls":3},"exosomal secretion;negative regulation of apoptotic process;nucleotide-excision repair, DNA damage recognition;positive regulation of DNA binding transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;post-translational protein modification;protein deneddylation;protein deubiquitination;regulation of cell cycle;regulation of IRE1-mediated unfolded protein response;regulation of JNK cascade;transcription from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair;translation","enzyme binding;macrophage migration inhibitory factor binding;metal ion binding;metallopeptidase activity;NEDD8-specific protease activity;thiol-dependent ubiquitin-specific protease activity;transcription coactivator activity;translation initiation factor activity","cell junction;COP9 signalosome;cytoplasm;cytosol;eukaryotic translation initiation factor 3 complex;nucleoplasm;nucleus;perinuclear region of cytoplasm;synaptic vesicle",{"$nulls":3},12,12,12,50,50,50,"37.578",0,"90.843",1009000000,46,"0.419188",1,"0.443122","1.11489","sp|Q92905|CSN5_HUMAN;tr|E5RHH5|E5RHH5_HUMAN;tr|E5RHF2|E5RHF2_HUMAN;tr|E5RFS1|E5RFS1_HUMAN;tr|E5RG35|E5RG35_HUMAN;tr|E5RK55|E5RK55_HUMAN","sp|Q92905|CSN5_HUMAN;tr|E5RHH5|E5RHH5_HUMAN",3550,"Q92905","CSN5_HUMAN","COP9 signalosome complex subunit 5","GN5;ignalosome subunit 5","COPS5"]
["16.4885",1,"15.6063",1,{"$nulls":3},"mitochondrial translation;mitochondrial translational termination;ribosome disassembly","GTP binding;GTPase activity","mitochondrial matrix",{"$nulls":3},2,2,2,4,4,4,"86.6","0.00024704","6.1484",13673000,1,"0.012909",1,"0.441067","0.0414355","sp|Q969S9|RRF2M_HUMAN;tr|D6RF75|D6RF75_HUMAN;tr|D6RAL1|D6RAL1_HUMAN","sp|Q969S9|RRF2M_HUMAN;tr|D6RF75|D6RF75_HUMAN;tr|D6RAL1|D6RAL1_HUMAN",3583,"Q969S9","RRF2M_HUMAN","Ribosome-releasing factor 2, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03059}","RF2mt {ECO:0000255|HAMAP-Rule:MF_03059}","GFM2"]
["18.1021","19.7239","18.2868","18.6591",{"$nulls":3},"interstrand cross-link repair;mitotic G2 DNA damage checkpoint;positive regulation of protein ubiquitination","DNA binding;DNA polymerase binding","cytosol;membrane;nucleoplasm","Fanconi anemia pathway",null,null,20,20,20,"18.4","18.4","18.4","149.32",0,"46.966",395800000,44,"0.187305",1,"0.440079","0.528957","sp|Q9NVI1|FANCI_HUMAN;tr|F8W7R3|F8W7R3_HUMAN;tr|H3BP78|H3BP78_HUMAN;tr|H3BMG4|H3BMG4_HUMAN;tr|H3BS60|H3BS60_HUMAN;tr|H3BQE2|H3BQE2_HUMAN;tr|H3BT54|H3BT54_HUMAN;tr|H3BN35|H3BN35_HUMAN","sp|Q9NVI1|FANCI_HUMAN;tr|F8W7R3|F8W7R3_HUMAN;tr|H3BP78|H3BP78_HUMAN",4491,"Q9NVI1","FANCI_HUMAN","Fanconi anemia group I protein","rotein FACI","FANCI"]
["21.5132","21.7313","21.7818","20.5839",{"$nulls":3},"actin filament organization;cell cycle;cell division;cell-cell adhesion;negative regulation of small GTPase mediated signal transduction;negative regulation of transforming growth factor beta1 production;positive regulation of protein localization to nucleus;proteasome-mediated ubiquitin-dependent protein catabolic process;protein complex assembly;regulation of actin cytoskeleton reorganization;regulation of receptor-mediated endocytosis;signal transduction;substrate-dependent cell migration, cell extension;vesicle organization","beta-catenin binding;cadherin binding;protein complex binding;protein C-terminus binding;SH3 domain binding;structural constituent of cytoskeleton;vascular endothelial growth factor receptor binding","actin cytoskeleton;cell-cell junction;cytoplasm;endocytic vesicle;extracellular exosome;filamentous actin;perinuclear region of cytoplasm;plasma membrane;ruffle","Bacterial invasion of epithelial cells",null,null,20,20,20,"37.9","37.9","37.9","71.45",0,"66.672",898400000,82,"0.26325",1,"0.439393","0.721709","sp|Q9Y5K6|CD2AP_HUMAN","sp|Q9Y5K6|CD2AP_HUMAN",5042,"Q9Y5K6","CD2AP_HUMAN","CD2-associated protein",null,"CD2AP"]
["20.9104","21.7459","21.1612","20.6167",{"$nulls":3},"cellular response to DNA damage stimulus;methylation;regulation of response to DNA damage stimulus","enzyme binding;protein carboxyl O-methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity",{"$nulls":4},8,8,8,"25.6","25.6","25.6","51.172",0,"125.59",479480000,27,"0.326728",1,"0.439262","0.88094","sp|Q9H993|ARMT1_HUMAN;tr|F5GZY1|F5GZY1_HUMAN","sp|Q9H993|ARMT1_HUMAN;tr|F5GZY1|F5GZY1_HUMAN",4270,"Q9H993","ARMT1_HUMAN","Protein-glutamate O-methyltransferase {ECO:0000305}",null,"ARMT1"]
["24.9212","24.513","25.2387","23.3177",{"$nulls":4},"RNA binding","nucleoplasm",{"$nulls":3},13,13,13,"45.3","45.3","45.3","33.155",0,"318.28",4243900000,142,"0.155726",1,"0.438854","0.446912","tr|F8W6I7|F8W6I7_HUMAN;sp|P09651|ROA1_HUMAN;tr|F8VZ49|F8VZ49_HUMAN;tr|F8VTQ5|F8VTQ5_HUMAN;sp|Q32P51|RA1L2_HUMAN;tr|F8VYN5|F8VYN5_HUMAN;tr|F8W646|F8W646_HUMAN;tr|H0YH80|H0YH80_HUMAN","tr|F8W6I7|F8W6I7_HUMAN;sp|P09651|ROA1_HUMAN;tr|F8VZ49|F8VZ49_HUMAN;tr|F8VTQ5|F8VTQ5_HUMAN;sp|Q32P51|RA1L2_HUMAN",951,"F8W6I7","F8W6I7_HUMAN",null,null,"HNRNPA1"]
["20.1061","20.4231","20.1524","19.5007",{"$nulls":3},"axon guidance","actin binding;SH3 domain binding;WW domain binding","cell junction;cytoskeleton;cytosol;filopodium;focal adhesion;lamellipodium;plasma membrane;synapse","Axon guidance;Rap1 signaling pathway;Regulation of actin cytoskeleton",null,null,11,11,5,"26.2","26.2","15.1","66.509",0,"76.541",257590000,26,"0.455651",1,"0.438031","1.2089","sp|Q8N8S7|ENAH_HUMAN","sp|Q8N8S7|ENAH_HUMAN",3264,"Q8N8S7","ENAH_HUMAN","Protein enabled homolog",null,"ENAH"]
["17.7944","18.4303","18.1733","17.176",{"$nulls":3},"coenzyme A biosynthetic process","ATP binding;pantothenate kinase activity","cytoplasm","Metabolic pathways;Pantothenate and CoA biosynthesis",null,null,4,4,4,"5.7","5.7","5.7","85.99",0,"15.801",97587000,10,"0.270594",1,"0.437706","0.740159","sp|Q9NVE7|PANK4_HUMAN;tr|H0YA26|H0YA26_HUMAN;tr|A0A0G2JR38|A0A0G2JR38_HUMAN;tr|E9PHT6|E9PHT6_HUMAN;tr|H0Y9E4|H0Y9E4_HUMAN","sp|Q9NVE7|PANK4_HUMAN;tr|H0YA26|H0YA26_HUMAN;tr|A0A0G2JR38|A0A0G2JR38_HUMAN;tr|E9PHT6|E9PHT6_HUMAN;tr|H0Y9E4|H0Y9E4_HUMAN",4486,"Q9NVE7","PANK4_HUMAN","Pantothenate kinase 4","PanK4","PANK4"]
["20.908","21.09","19.3185","21.8047",{"$nulls":3},"carbohydrate metabolic process;GDP-mannose biosynthetic process","mannose-6-phosphate isomerase activity;zinc ion binding",{"$nulls":4},8,8,8,"28.8","28.8","28.8","44.45",0,"24.994",284380000,17,"0.119671",1,"0.437429","0.35094","tr|H3BPB8|H3BPB8_HUMAN;sp|P34949|MPI_HUMAN;tr|H3BMZ9|H3BMZ9_HUMAN;tr|H3BPP3|H3BPP3_HUMAN;tr|H3BP57|H3BP57_HUMAN;tr|H3BT48|H3BT48_HUMAN;tr|H3BUZ9|H3BUZ9_HUMAN;tr|F5GX71|F5GX71_HUMAN;tr|H3BPM5|H3BPM5_HUMAN;tr|H3BPU7|H3BPU7_HUMAN;tr|H3BQX0|H3BQX0_HUMAN;tr|H3BNY8|H3BNY8_HUMAN;tr|H3BT46|H3BT46_HUMAN;tr|H3BU66|H3BU66_HUMAN;tr|H3BN01|H3BN01_HUMAN;tr|H3BUG1|H3BUG1_HUMAN;tr|B4DYB8|B4DYB8_HUMAN","tr|H3BPB8|H3BPB8_HUMAN;sp|P34949|MPI_HUMAN;tr|H3BMZ9|H3BMZ9_HUMAN;tr|H3BPP3|H3BPP3_HUMAN;tr|H3BP57|H3BP57_HUMAN;tr|H3BT48|H3BT48_HUMAN;tr|H3BUZ9|H3BUZ9_HUMAN;tr|F5GX71|F5GX71_HUMAN;tr|H3BPM5|H3BPM5_HUMAN;tr|H3BPU7|H3BPU7_HUMAN;tr|H3BQX0|H3BQX0_HUMAN;tr|H3BNY8|H3BNY8_HUMAN;tr|H3BT46|H3BT46_HUMAN",1368,"H3BPB8","H3BPB8_HUMAN","Mannose-6-phosphate isomerase {ECO:0000256|RuleBase:RU000611}"]
["26.1691","26.15","26.3567","25.0888",{"$nulls":3},"positive regulation of cell proliferation","actin binding;calmodulin binding","cytoplasm;extracellular exosome;plasma membrane","Fc gamma R-mediated phagocytosis;Leishmaniasis",null,null,5,5,5,"68.7","68.7","68.7","19.529",0,"134.32",3422000000,85,"0.250206",1,"0.436789","0.688889","sp|P49006|MRP_HUMAN","sp|P49006|MRP_HUMAN",1557,"P49006","MRP_HUMAN","MARCKS-related protein",null,"MARCKSL1"]
["15.9973","14.6725","15.7128","14.0841",{"$nulls":3},"actin cytoskeleton organization;adrenal gland development;amygdala development;artery morphogenesis;brain development;camera-type eye morphogenesis;cell communication;cellular response to heat;cerebral cortex development;cognition;collagen fibril organization;extracellular matrix organization;extrinsic apoptotic signaling pathway via death domain receptors;forebrain astrocyte development;forebrain morphogenesis;gamma-aminobutyric acid secretion, neurotransmission;glutamate secretion, neurotransmission;hair follicle maturation;heart development;liver development;MAPK cascade;metanephros development;myelination in peripheral nervous system;negative regulation of angiogenesis;negative regulation of astrocyte differentiation;negative regulation of cell migration;negative regulation of cell-matrix adhesion;negative regulation of endothelial cell proliferation;negative regulation of fibroblast proliferation;negative regulation of MAP kinase activity;negative regulation of MAPK cascade;negative regulation of neuroblast proliferation;negative regulation of neurotransmitter secretion;negative regulation of oligodendrocyte differentiation;negative regulation of osteoclast differentiation;negative regulation of protein kinase activity;negative regulation of Rac protein signal transduction;negative regulation of Ras protein signal transduction;negative regulation of transcription factor import into nucleus;neural tube development;observational learning;osteoblast differentiation;peripheral nervous system development;phosphatidylinositol 3-kinase signaling;pigmentation;positive regulation of adenylate cyclase activity;positive regulation of apoptotic process;positive regulation of endothelial cell proliferation;positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;positive regulation of GTPase activity;positive regulation of neuron apoptotic process;Ras protein signal transduction;regulation of angiogenesis;regulation of blood vessel endothelial cell migration;regulation of bone resorption;regulation of cell-matrix adhesion;regulation of gene expression;regulation of glial cell differentiation;regulation of GTPase activity;regulation of long-term neuronal synaptic plasticity;regulation of long-term synaptic potentiation;regulation of synaptic transmission, GABAergic;response to hypoxia;Schwann cell development;skeletal muscle tissue development;smooth muscle tissue development;spinal cord development;sympathetic nervous system development;visual learning;wound healing","GTPase activator activity;phosphatidylcholine binding;phosphatidylethanolamine binding","axon;cytoplasm;cytosol;dendrite;intrinsic component of the cytoplasmic side of the plasma membrane;membrane;nucleolus;nucleus;presynapse","EGFR tyrosine kinase inhibitor resistance;MAPK signaling pathway;Ras signaling pathway",null,null,22,22,22,"11.1","11.1","11.1","319.37",0,"49.216",298950000,55,"0.143895",1,"0.436419","0.415731","sp|P21359|NF1_HUMAN;tr|H0Y465|H0Y465_HUMAN;tr|J3KSB5|J3KSB5_HUMAN;tr|J3QSG6|J3QSG6_HUMAN;tr|K7EP94|K7EP94_HUMAN;tr|J3QLS2|J3QLS2_HUMAN;tr|K7EID4|K7EID4_HUMAN;tr|J3KRT8|J3KRT8_HUMAN;tr|J3QQN8|J3QQN8_HUMAN","sp|P21359|NF1_HUMAN;tr|H0Y465|H0Y465_HUMAN",1164,"P21359","NF1_HUMAN","Neurofibromin",null,"NF1"]
["19.4959","19.6628","19.2319","19.0541",{"$nulls":5},"cytoplasmic ribonucleoprotein granule;nuclear speck",{"$nulls":3},3,3,3,"20.6","20.6","20.6","23.661",0,"33.508",72333000,12,"1.15493",1,"0.436345","3.57837","tr|X6R700|X6R700_HUMAN;sp|Q9Y3Y2|CHTOP_HUMAN;tr|A0A087X1B7|A0A087X1B7_HUMAN","tr|X6R700|X6R700_HUMAN;sp|Q9Y3Y2|CHTOP_HUMAN",4999,"X6R700","X6R700_HUMAN",null,null,"CHTOP"]
["19.8809","18.4816","19.3933","18.0982",{"$nulls":9},3,3,3,"22.3","22.3","22.3","21.529",0,"8.8289",50985000,9,"0.159513",1,"0.435515","0.456838","tr|D6RJ90|D6RJ90_HUMAN;sp|Q9Y6G5|COMDA_HUMAN;tr|H0Y9N4|H0Y9N4_HUMAN;tr|D6RC04|D6RC04_HUMAN","tr|D6RJ90|D6RJ90_HUMAN;sp|Q9Y6G5|COMDA_HUMAN;tr|H0Y9N4|H0Y9N4_HUMAN;tr|D6RC04|D6RC04_HUMAN",5093,"D6RJ90","D6RJ90_HUMAN"]
["22.6209","20.0572","22.7721","19.0367",{"$nulls":3},"regulation of cell motility;regulation of microtubule-based process",null,"cytosol;nucleus",{"$nulls":3},5,5,5,"23.2","23.2","23.2","33.733",0,"24.009",401540000,16,"0.0627146",1,"0.43471","0.191903","sp|Q9Y316|MEMO1_HUMAN","sp|Q9Y316|MEMO1_HUMAN",4958,"Q9Y316","MEMO1_HUMAN","Protein MEMO1",null,"MEMO1"]
["14.7182","15.0358","14.4211","14.4645",{"$nulls":3},"covalent chromatin modification","chromatin binding;methylated histone binding;RNA binding;transcription coactivator activity","cytoplasm;nucleus",{"$nulls":3},2,2,2,"4.3","4.3","4.3","73.184","0.00068384","4.4539",15060000,9,"0.944774",1,"0.43416","2.70851","sp|Q9H7E2|TDRD3_HUMAN","sp|Q9H7E2|TDRD3_HUMAN",4242,"Q9H7E2","TDRD3_HUMAN","Tudor domain-containing protein 3",null,"TDRD3"]
["19.8564","21.4442","20.6356","19.7983",{"$nulls":5},"nucleoplasm",{"$nulls":3},3,3,3,"18.3","18.3","18.3","17.546",0,"9.8584",341470000,54,"0.169473",1,"0.433343","0.482823","tr|J3QLE5|J3QLE5_HUMAN;sp|P63162|RSMN_HUMAN;sp|P14678|RSMB_HUMAN;tr|A8MT02|A8MT02_HUMAN;tr|J3KRY3|J3KRY3_HUMAN;tr|S4R3P3|S4R3P3_HUMAN","tr|J3QLE5|J3QLE5_HUMAN;sp|P63162|RSMN_HUMAN;sp|P14678|RSMB_HUMAN;tr|A8MT02|A8MT02_HUMAN",1049,"J3QLE5","J3QLE5_HUMAN",null,null,"SNRPN"]
["20.9357","21.0933","20.7476","20.4147",{"$nulls":3},"cell separation after cytokinesis;cholesterol transport;endosomal transport;endosome to lysosome transport via multivesicular body sorting pathway;ESCRT III complex disassembly;late endosomal microautophagy;macroautophagy;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of cell death;negative regulation of exosomal secretion;nucleus organization;positive regulation of centriole elongation;positive regulation of exosomal secretion;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of viral life cycle;positive regulation of viral process;positive regulation of viral release from host cell;potassium ion transport;protein depolymerization;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;regulation of viral process;response to lipid;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;viral budding via host ESCRT complex;viral life cycle;viral release from host cell","ATP binding;ATPase activity;ATPase activity, coupled;identical protein binding;protein C-terminus binding;protein homodimerization activity","centrosome;cytoplasm;cytosol;endosome;endosome membrane;extracellular exosome;Flemming body;late endosome membrane;nucleus;spindle pole","Endocytosis;Necroptosis",null,null,12,12,10,"34.2","34.2","29.7","49.301",0,"27.441",430350000,37,"0.844911",1,"0.43332","2.35276","sp|O75351|VPS4B_HUMAN;tr|K7EL71|K7EL71_HUMAN;tr|K7EKZ3|K7EKZ3_HUMAN","sp|O75351|VPS4B_HUMAN",549,"O75351","VPS4B_HUMAN","Vacuolar protein sorting-associated protein 4B",null,"VPS4B"]
["19.6668","19.8232","19.715","18.9116",{"$nulls":3},"cellular response to stimulus;oligodendrocyte development;regulation of molecular function;response to glucose;response to heat;response to peptide hormone;translational initiation","identical protein binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex;membrane;plasma membrane","Herpes simplex virus 1 infection;RNA transport",null,null,9,9,9,"35.4","35.4","35.4","33.712",0,"22.351",257780000,29,"0.395712",1,"0.431701","1.055","sp|Q14232|EI2BA_HUMAN;tr|F5H0D0|F5H0D0_HUMAN;tr|H0YGG4|H0YGG4_HUMAN","sp|Q14232|EI2BA_HUMAN;tr|F5H0D0|F5H0D0_HUMAN",2348,"Q14232","EI2BA_HUMAN","Translation initiation factor eIF-2B subunit alpha",null,"EIF2B1"]
["16.8703","15.5927","17.4319","14.168",{"$nulls":3},"axon guidance;axonal fasciculation;camera-type eye development;cell migration;cellular response to extracellular stimulus;central nervous system neuron axonogenesis;establishment or maintenance of actin cytoskeleton polarity;forebrain development;mammary gland development;negative regulation of Rho protein signal transduction;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of vascular permeability;neural tube closure;neuron projection guidance;positive regulation of cilium assembly;positive regulation of neuron projection development;regulation of actin cytoskeleton organization;regulation of actin polymerization or depolymerization;regulation of axonogenesis;regulation of cell shape;regulation of small GTPase mediated signal transduction;signal transduction;transcription, DNA-templated;wound healing, spreading of cells","DNA binding;GTP binding;GTPase activator activity;GTPase activity;phospholipid binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription corepressor activity;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","actin cytoskeleton;ciliary basal body;cytoplasm;cytosol;nucleus;plasma membrane","Focal adhesion;Leukocyte transendothelial migration;Platelet activation;Regulation of actin cytoskeleton",null,null,10,10,10,"9.8","9.8","9.8","170.51",0,"16.508",89264000,20,"0.0817248",1,"0.431535","0.246234","sp|Q9NRY4|RHG35_HUMAN;tr|A2RRE5|A2RRE5_HUMAN","sp|Q9NRY4|RHG35_HUMAN;tr|A2RRE5|A2RRE5_HUMAN",4431,"Q9NRY4","RHG35_HUMAN","Rho GTPase-activating protein 35 {ECO:0000312|HGNC:HGNC:4591}",null,"ARHGAP35"]
["16.4269","19.0525","16.2643","18.3523",{"$nulls":9},4,4,4,"8.4","8.4","8.4","67.255",0,"9.1813",65406000,10,"0.0856279",1,"0.431434","0.257218","tr|A0A0D9SEU5|A0A0D9SEU5_HUMAN;sp|Q6VN20|RBP10_HUMAN;tr|R4GMX8|R4GMX8_HUMAN;tr|R4GMX7|R4GMX7_HUMAN;tr|R4GNA3|R4GNA3_HUMAN;tr|R4GN91|R4GN91_HUMAN","tr|A0A0D9SEU5|A0A0D9SEU5_HUMAN;sp|Q6VN20|RBP10_HUMAN;tr|R4GMX8|R4GMX8_HUMAN",2916,"A0A0D9SEU5","A0A0D9SEU5_HUMAN",null,null,"RANBP10"]
[1,"18.0431",1,"17.1812",{"$nulls":3},"BMP signaling pathway;bone development;cardiac muscle contraction;cartilage development;cellular response to organic cyclic compound;embryonic pattern specification;erythrocyte differentiation;germ cell development;Mullerian duct regression;negative regulation of transcription from RNA polymerase II promoter;osteoblast fate commitment;positive regulation of osteoblast differentiation;positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;positive regulation of transcription, DNA-templated;protein phosphorylation;signal transduction;SMAD protein signal transduction;transcription, DNA-templated;transforming growth factor beta receptor signaling pathway;ureteric bud development","DEAD/H-box RNA helicase binding;DNA binding transcription factor activity;metal ion binding;RNA polymerase II core promoter sequence-specific DNA binding;signal transducer activity, downstream of receptor;transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity;ubiquitin protein ligase binding","cytoplasm;cytosol;integral component of membrane;intracellular;nucleoplasm;nucleus;protein complex;SMAD protein complex;transcription factor complex","Signaling pathways regulating pluripotency of stem cells;TGF-beta signaling pathway",null,null,3,3,3,"10.5","10.5","10.5","52.258","0.00069348","4.724",16560000,2,"0.0114075",1,"0.430955","0.0366755","sp|Q99717|SMAD5_HUMAN;tr|H0YAK7|H0YAK7_HUMAN;sp|Q15797|SMAD1_HUMAN","sp|Q99717|SMAD5_HUMAN;tr|H0YAK7|H0YAK7_HUMAN;sp|Q15797|SMAD1_HUMAN",3876,"Q99717","SMAD5_HUMAN","Mothers against decapentaplegic homolog 5","AD homolog 5;others against DPP homolog 5","SMAD5"]
["18.2693","17.8017","18.6616","16.548",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;antimicrobial humoral response;defense response to bacterium;defense response to fungus;defense response to Gram-negative bacterium;defense response to Gram-positive bacterium;killing of cells of other organism","peptidase activity;RNA binding","extracellular exosome;extracellular matrix;extracellular region;extracellular space",{"$nulls":3},3,3,3,"32.7","32.7","32.7","11.284",0,"8.0651",245860000,13,"0.137176",1,"0.430661","0.397894","sp|P81605|DCD_HUMAN","sp|P81605|DCD_HUMAN",1986,"P81605","DCD_HUMAN","Dermcidin",null,"DCD"]
[1,"21.5239",1,"20.6628",{"$nulls":3},"chaperone-mediated protein transport;protein import into mitochondrial inner membrane;protein targeting to mitochondrion;sensory perception of sound","protein transporter activity;zinc ion binding","fibrillar center;mitochondrial inner membrane;mitochondrial intermembrane space protein transporter complex;mitochondrion",{"$nulls":3},2,2,2,"26.3","26.3","26.3","10.5","0.00025806","7.046",90598000,5,"0.00940188",1,"0.430516","0.0302937","sp|Q9Y5L4|TIM13_HUMAN","sp|Q9Y5L4|TIM13_HUMAN",5046,"Q9Y5L4","TIM13_HUMAN","Mitochondrial import inner membrane translocase subunit Tim13",null,"TIMM13"]
["17.9506","18.5028","18.1625","17.4306",{"$nulls":3},"MyD88-dependent toll-like receptor signaling pathway;negative regulation of ERK1 and ERK2 cascade;negative regulation of I-kappaB kinase/NF-kappaB signaling;regulation of inflammatory response",{"$nulls":5},3,3,3,"8.9","8.9","8.9","55.697",0,"13.303",44378000,11,"0.349591",1,"0.430147","0.938387","tr|E7EMV7|E7EMV7_HUMAN;tr|A0A0A0MRZ4|A0A0A0MRZ4_HUMAN;sp|Q15025|TNIP1_HUMAN;tr|E7EW15|E7EW15_HUMAN;tr|E7EWG2|E7EWG2_HUMAN;tr|E7EW68|E7EW68_HUMAN;tr|H0YC17|H0YC17_HUMAN","tr|E7EMV7|E7EMV7_HUMAN;tr|A0A0A0MRZ4|A0A0A0MRZ4_HUMAN;sp|Q15025|TNIP1_HUMAN;tr|E7EW15|E7EW15_HUMAN",2430,"E7EMV7","E7EMV7_HUMAN",null,null,"TNIP1"]
["18.9882","18.685","19.4896","17.3237",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity",{"$nulls":4},5,4,4,"41.2","36.5","36.5","18.685","0.00024486","5.8584",50815000,12,"0.135396",1,"0.429922","0.393154","tr|F8VYH9|F8VYH9_HUMAN;tr|F8VTV8|F8VTV8_HUMAN;tr|F8VWX7|F8VWX7_HUMAN;sp|P11802|CDK4_HUMAN;tr|F8VYY1|F8VYY1_HUMAN;tr|Q96BE9|Q96BE9_HUMAN;tr|F8W1L8|F8W1L8_HUMAN;tr|F8VXD2|F8VXD2_HUMAN;tr|F8VZZ0|F8VZZ0_HUMAN;tr|F8VZ51|F8VZ51_HUMAN","tr|F8VYH9|F8VYH9_HUMAN;tr|F8VTV8|F8VTV8_HUMAN;tr|F8VWX7|F8VWX7_HUMAN;sp|P11802|CDK4_HUMAN;tr|F8VYY1|F8VYY1_HUMAN;tr|Q96BE9|Q96BE9_HUMAN;tr|F8W1L8|F8W1L8_HUMAN",1003,"F8VYH9","F8VYH9_HUMAN",null,null,"CDK4"]
["19.1708","19.3479","19.6228","18.0368",{"$nulls":3},"acute-phase response;negative regulation of chemokine biosynthetic process;negative regulation of cytokine-mediated signaling pathway;negative regulation of DNA binding transcription factor activity;negative regulation of lipopolysaccharide-mediated signaling pathway;signal transduction",null,"integral component of membrane;membrane",{"$nulls":3},6,6,6,"20.2","20.2","20.2","45.679",0,"16.882",175700000,16,"0.190945",1,"0.42954","0.538322","sp|Q6IA17|SIGIR_HUMAN;tr|H0YDF8|H0YDF8_HUMAN;tr|C9JFX4|C9JFX4_HUMAN;tr|H0YDR5|H0YDR5_HUMAN;tr|E9PLG6|E9PLG6_HUMAN","sp|Q6IA17|SIGIR_HUMAN;tr|H0YDF8|H0YDF8_HUMAN;tr|C9JFX4|C9JFX4_HUMAN",2814,"Q6IA17","SIGIR_HUMAN","Single Ig IL-1-related receptor",null,"SIGIRR"]
["21.9929","21.9704","21.6302","21.4756",{"$nulls":3},"mitochondrial calcium ion transmembrane transport;protein processing involved in protein targeting to mitochondrion;proteolysis","metalloendopeptidase activity;zinc ion binding","extracellular space;mitochondrial inner membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},12,12,12,"31.4","31.4","31.4","58.252",0,"92.776",872240000,44,"1.50004",1,"0.428761","5.48942","sp|Q10713|MPPA_HUMAN;tr|Q5SXN9|Q5SXN9_HUMAN","sp|Q10713|MPPA_HUMAN",2152,"Q10713","MPPA_HUMAN","Mitochondrial-processing peptidase subunit alpha",null,"PMPCA"]
["15.6826","13.7873","15.7447","12.8699",{"$nulls":3},"centrosome localization;cytoskeletal anchoring at nuclear membrane;establishment or maintenance of cell polarity;fibroblast migration;nuclear envelope organization;nuclear migration;nuclear migration along microfilament;nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;positive regulation of cell migration;protein localization to nucleus;regulation of cilium assembly","actin binding;actin filament binding","aggresome;cytoplasm;extracellular exosome;filopodium membrane;focal adhesion;integral component of membrane;intermediate filament cytoskeleton;lamellipodium membrane;LINC complex;mitochondrion;nuclear envelope;nuclear lumen;nuclear membrane;nuclear outer membrane;nucleoplasm;nucleus;sarcoplasmic reticulum;sarcoplasmic reticulum membrane;Z disc",{"$nulls":3},30,30,30,"5.8","5.8","5.8","796.43",0,"65.983",377220000,64,"0.082492",1,"0.427656","0.248397","sp|Q8WXH0|SYNE2_HUMAN;tr|G3V5X4|G3V5X4_HUMAN;tr|A0A0A0MRE3|A0A0A0MRE3_HUMAN;tr|A0A0C4DGK3|A0A0C4DGK3_HUMAN;tr|G3V4T3|G3V4T3_HUMAN;tr|G3V3D4|G3V3D4_HUMAN;tr|G3V5D3|G3V5D3_HUMAN;tr|A0A0C4DH87|A0A0C4DH87_HUMAN","sp|Q8WXH0|SYNE2_HUMAN;tr|G3V5X4|G3V5X4_HUMAN;tr|A0A0A0MRE3|A0A0A0MRE3_HUMAN",3464,"Q8WXH0","SYNE2_HUMAN","Nesprin-2",null,"SYNE2"]
[1,"14.8221",1,"13.9702",{"$nulls":3},"embryonic skeletal system development",null,"cytoplasm",{"$nulls":3},4,4,4,"2.5","2.5","2.5","214.11","0.00067355","4.213",32319000,2,"0.0140186",1,"0.425939","0.0449431","sp|Q5T5P2|SKT_HUMAN;tr|Q5T5P0|Q5T5P0_HUMAN;tr|Q5T5P1|Q5T5P1_HUMAN","sp|Q5T5P2|SKT_HUMAN",2729,"Q5T5P2","SKT_HUMAN","Sickle tail protein homolog",null,"KIAA1217"]
["20.1497","19.9202","20.4452","18.774",{"$nulls":3},"endosome to lysosome transport;membrane organization;receptor-mediated endocytosis;secretion of lysosomal enzymes","mannose binding;mannose transmembrane transporter activity;retromer complex binding;transmembrane signaling receptor activity","clathrin-coated vesicle membrane;endosome;integral component of plasma membrane;late endosome;lysosomal membrane;membrane;perinuclear region of cytoplasm;plasma membrane;trans-Golgi network;trans-Golgi network membrane;transport vesicle","Lysosome;Phagosome",null,null,3,3,3,"14.1","14.1","14.1","30.993",0,"12.845",137330000,14,"0.177773",1,"0.425387","0.504354","sp|P20645|MPRD_HUMAN;tr|F5GX30|F5GX30_HUMAN;tr|F5GXE0|F5GXE0_HUMAN;tr|H0YGE9|H0YGE9_HUMAN;tr|F5GXU0|F5GXU0_HUMAN;tr|H0YGT2|H0YGT2_HUMAN;tr|F5H883|F5H883_HUMAN;tr|H0YF90|H0YF90_HUMAN","sp|P20645|MPRD_HUMAN;tr|F5GX30|F5GX30_HUMAN",1152,"P20645","MPRD_HUMAN","Cation-dependent mannose-6-phosphate receptor","D Man-6-P receptor;D-MPR","M6PR"]
["23.5407","24.0572","23.3317","23.4166",{"$nulls":3},"regulation of transcription, DNA-templated","cadherin binding;DNA binding;lamin binding","chromatin;nuclear envelope;nucleus",{"$nulls":3},35,35,24,70,70,"50.6","75.491",0,"323.31",13435000000,612,"0.609044",1,"0.424824","1.62326","sp|P42166|LAP2A_HUMAN","sp|P42166|LAP2A_HUMAN",1464,"P42166","LAP2A_HUMAN","Lamina-associated polypeptide 2, isoform alpha",null,"TMPO"]
["19.83","19.3013","20.0942","18.1892",{"$nulls":9},4,4,4,"21.1","21.1","21.1","23.373",0,"8.3304",95403000,12,"0.148883",1,"0.423973","0.42891","tr|H7C519|H7C519_HUMAN;sp|Q9H857|NT5D2_HUMAN;tr|H7C4G8|H7C4G8_HUMAN","tr|H7C519|H7C519_HUMAN;sp|Q9H857|NT5D2_HUMAN",4253,"H7C519","H7C519_HUMAN",null,null,"NT5DC2"]
["19.9112","21.3917","20.141","20.3144",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;ER to Golgi vesicle-mediated transport;nuclear migration","protein N-terminus binding","centrosome;cytoplasm;cytoplasmic dynein complex;cytosol;dynactin complex;focal adhesion;kinetochore;nucleus;spindle pole;stress fiber","Huntington disease;Vasopressin-regulated water reabsorption",null,null,8,8,8,"30.4","30.4","30.4","52.337",0,"25.506",274890000,34,"0.202737",1,"0.423745","0.568542","sp|Q9UJW0|DCTN4_HUMAN;tr|E5RGG1|E5RGG1_HUMAN;tr|H9KVE0|H9KVE0_HUMAN;tr|E5RI97|E5RI97_HUMAN;tr|E5RK21|E5RK21_HUMAN","sp|Q9UJW0|DCTN4_HUMAN",4771,"Q9UJW0","DCTN4_HUMAN","Dynactin subunit 4","yn4","DCTN4"]
["20.829","20.9974","20.6962","20.2844",{"$nulls":3},"cell proliferation;mRNA splicing, via spliceosome;neuronal stem cell population maintenance;positive regulation of neurogenesis;primary miRNA processing;regulation of transcription, DNA-templated;response to arsenic-containing substance;snRNA transcription from RNA polymerase II promoter","DNA binding;RNA binding","cytoplasm;nucleoplasm;protein complex",{"$nulls":3},17,17,17,"27.2","27.2","27.2","100.67",0,"95.41",764390000,75,"0.704234",1,"0.422924","1.90152","sp|Q9BXP5|SRRT_HUMAN;tr|H7C3A1|H7C3A1_HUMAN;tr|H7C1K0|H7C1K0_HUMAN;tr|H7C0U8|H7C0U8_HUMAN;tr|A0A0A0MSP6|A0A0A0MSP6_HUMAN","sp|Q9BXP5|SRRT_HUMAN;tr|H7C3A1|H7C3A1_HUMAN",4045,"Q9BXP5","SRRT_HUMAN","Serrate RNA effector molecule homolog",null,"SRRT"]
[1,"16.3224",1,"15.4774",{"$nulls":9},3,3,3,"4.2","4.2","4.2","106.01",0,"8.679",8677400,6,"0.012482",1,"0.422481","0.0400833","tr|A0A0A0MTP7|A0A0A0MTP7_HUMAN;tr|F8VXG7|F8VXG7_HUMAN;sp|Q99590|SCAFB_HUMAN","tr|A0A0A0MTP7|A0A0A0MTP7_HUMAN;tr|F8VXG7|F8VXG7_HUMAN;sp|Q99590|SCAFB_HUMAN",3862,"A0A0A0MTP7","A0A0A0MTP7_HUMAN",null,null,"SCAF11"]
["19.9529","19.3438","19.9717","18.4818",{"$nulls":4},"O-methyltransferase activity","integral component of membrane;mitochondrion",{"$nulls":3},6,6,6,"36.6","36.6","36.6","28.808",0,"24.766",102500000,26,"0.185347",1,"0.421649","0.523914","sp|Q86VU5|CMTD1_HUMAN;tr|R4GNF4|R4GNF4_HUMAN","sp|Q86VU5|CMTD1_HUMAN;tr|R4GNF4|R4GNF4_HUMAN",3064,"Q86VU5","CMTD1_HUMAN","Catechol O-methyltransferase domain-containing protein 1",null,"COMTD1"]
["19.8808","20.0746","19.232","19.8803",{"$nulls":3},"neutrophil degranulation","metal ion binding;phosphoprotein phosphatase activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region;plasma membrane",{"$nulls":3},4,4,4,"12.4","12.4","12.4","35.548",0,"10.112",115000000,10,"0.469932",1,"0.421545","1.2461","sp|Q9BRF8|CPPED_HUMAN","sp|Q9BRF8|CPPED_HUMAN",3930,"Q9BRF8","CPPED_HUMAN","Serine/threonine-protein phosphatase CPPED1",null,"CPPED1"]
["20.1946","17.9345","20.4532","16.8341",{"$nulls":3},"purine nucleobase metabolic process;purine nucleotide metabolic process","GMP reductase activity;metal ion binding","GMP reductase complex",{"$nulls":3},6,6,6,"24.4","24.4","24.4","33.921",0,"13.312",85464000,5,"0.0645734",1,"0.42089","0.19728","tr|H0YMB3|H0YMB3_HUMAN;tr|H0YLV5|H0YLV5_HUMAN;tr|A0A087WWM4|A0A087WWM4_HUMAN;sp|Q9P2T1|GMPR2_HUMAN;tr|F8WAN9|F8WAN9_HUMAN;tr|H0YNJ6|H0YNJ6_HUMAN;tr|H0YLB8|H0YLB8_HUMAN;tr|H0YK13|H0YK13_HUMAN;tr|H0YNS9|H0YNS9_HUMAN;tr|H0YK71|H0YK71_HUMAN;tr|H0YNH0|H0YNH0_HUMAN;tr|H0YL68|H0YL68_HUMAN;tr|H0YN22|H0YN22_HUMAN;tr|H0YMW6|H0YMW6_HUMAN;tr|H0YMR9|H0YMR9_HUMAN;tr|H0YMV5|H0YMV5_HUMAN","tr|H0YMB3|H0YMB3_HUMAN;tr|H0YLV5|H0YLV5_HUMAN;tr|A0A087WWM4|A0A087WWM4_HUMAN;sp|Q9P2T1|GMPR2_HUMAN;tr|F8WAN9|F8WAN9_HUMAN;tr|H0YNJ6|H0YNJ6_HUMAN;tr|H0YLB8|H0YLB8_HUMAN;tr|H0YK13|H0YK13_HUMAN;tr|H0YNS9|H0YNS9_HUMAN;tr|H0YK71|H0YK71_HUMAN",4650,"H0YMB3","H0YMB3_HUMAN","GMP reductase {ECO:0000256|HAMAP-Rule:MF_03195}","MPR {ECO:0000256|HAMAP-Rule:MF_03195}","GMPR2"]
["23.2747","23.8975","23.2398","23.0949",{"$nulls":3},"cellular response to DNA damage stimulus;mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;regulation of gene expression;RNA export from nucleus;RNA secondary structure unwinding;termination of RNA polymerase II transcription","ATP binding;ATPase activity;ATP-dependent RNA helicase activity;identical protein binding;RNA binding","cytoplasm;membrane;nuclear speck;nucleolus;nucleoplasm;nucleus;spliceosomal complex",{"$nulls":3},14,14,5,37,37,"17.8","49.129",0,"112.04",1864600000,89,"0.494153",1,"0.41877","1.30973","sp|O00148|DX39A_HUMAN;tr|K7EQN7|K7EQN7_HUMAN;tr|K7EN69|K7EN69_HUMAN;tr|K7EPJ3|K7EPJ3_HUMAN;tr|K7ENP6|K7ENP6_HUMAN;tr|K7EL56|K7EL56_HUMAN;tr|K7EIL8|K7EIL8_HUMAN;tr|A0A0D9SEM9|A0A0D9SEM9_HUMAN;tr|F6SXL5|F6SXL5_HUMAN;tr|H0YCC6|H0YCC6_HUMAN","sp|O00148|DX39A_HUMAN;tr|K7EQN7|K7EQN7_HUMAN",189,"O00148","DX39A_HUMAN","ATP-dependent RNA helicase DDX39A",null,"DDX39A"]
["20.3335","20.1277","20.7","18.9257",{"$nulls":3},"apoptotic process;endoplasmic reticulum tubular network formation;endoplasmic reticulum tubular network organization;vesicle-mediated transport;viral process",null,"endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;extracellular space;Golgi membrane;integral component of membrane;plasma membrane","Alzheimer disease",null,null,2,2,2,"4.8","4.8","4.8","112.61",0,"32.057",364170000,22,"0.163693",1,"0.417757","0.467764","sp|O95197|RTN3_HUMAN;tr|B7Z4M1|B7Z4M1_HUMAN;tr|F5H891|F5H891_HUMAN;tr|F5GWG7|F5GWG7_HUMAN;tr|F5H617|F5H617_HUMAN","sp|O95197|RTN3_HUMAN;tr|B7Z4M1|B7Z4M1_HUMAN;tr|F5H891|F5H891_HUMAN;tr|F5GWG7|F5GWG7_HUMAN;tr|F5H617|F5H617_HUMAN",700,"O95197","RTN3_HUMAN","Reticulon-3",null,"RTN3"]
["20.2153","19.1576","20.3578","18.1878",{"$nulls":3},"co-translational protein modification;post-translational protein modification;protein N-linked glycosylation via asparagine","dolichyl-diphosphooligosaccharide-protein glycotransferase activity;metal ion binding","endoplasmic reticulum membrane;integral component of membrane;membrane;oligosaccharyltransferase complex","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,8,7,7,"9.8","8.8","8.8","80.529",0,"19.516",262550000,28,"0.116633",1,"0.413662","0.342713","sp|P46977|STT3A_HUMAN;tr|A0A0C4DH80|A0A0C4DH80_HUMAN;tr|E9PN73|E9PN73_HUMAN;tr|E9PI32|E9PI32_HUMAN","sp|P46977|STT3A_HUMAN",1524,"P46977","STT3A_HUMAN","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A","ligosaccharyl transferase subunit STT3A;TT3-A","STT3A"]
[1,"19.9411",1,"19.128",{"$nulls":3},"neutrophil degranulation",null,"azurophil granule membrane;ficolin-1-rich granule membrane;integral component of membrane;nuclear speck;nucleolus;plasma membrane;secretory granule membrane",{"$nulls":3},1,1,1,"7.3","7.3","7.3","23.55","0.00024673","6.109",35805000,6,"0.00962638",1,"0.406505","0.0310094","sp|Q7Z7N9|T179B_HUMAN","sp|Q7Z7N9|T179B_HUMAN",3026,"Q7Z7N9","T179B_HUMAN","Transmembrane protein 179B",null,"TMEM179B"]
["19.1833","18.3104","18.4302","18.2527",{"$nulls":3},"bicellular tight junction assembly",null,"bicellular tight junction;integral component of membrane",{"$nulls":3},5,5,5,"14.8","14.8","14.8","59.129",0,"14.765",114250000,8,"0.33843",1,"0.405421","0.910322","tr|A0A0G2JMZ8|A0A0G2JMZ8_HUMAN;sp|Q16625|OCLN_HUMAN","tr|A0A0G2JMZ8|A0A0G2JMZ8_HUMAN;sp|Q16625|OCLN_HUMAN",2556,"A0A0G2JMZ8","A0A0G2JMZ8_HUMAN",null,null,"OCLN"]
["18.04","17.4069","17.7273","16.9098",{"$nulls":3},"snRNA processing;snRNA transcription from RNA polymerase II promoter","metal ion binding","integrator complex;nucleoplasm;nucleus",{"$nulls":3},9,9,9,"22.1","22.1","22.1","48.807",0,"48.27",221850000,49,"0.287756",1,"0.404896","0.783219","sp|Q96CB8|INT12_HUMAN;tr|A0A087WXN4|A0A087WXN4_HUMAN;tr|E9PGI3|E9PGI3_HUMAN;tr|C9J0M6|C9J0M6_HUMAN;tr|A0A0K0K189|A0A0K0K189_HUMAN;tr|C9JDP3|C9JDP3_HUMAN;tr|D6R9W3|D6R9W3_HUMAN","sp|Q96CB8|INT12_HUMAN;tr|A0A087WXN4|A0A087WXN4_HUMAN;tr|E9PGI3|E9PGI3_HUMAN",3631,"Q96CB8","INT12_HUMAN","Integrator complex subunit 12","nt12","INTS12"]
["25.9919","26.4358","26.0943","25.5269",{"$nulls":3},"apoptotic process;blood coagulation, intrinsic pathway;complement activation, classical pathway;immune response;innate immune response;mature ribosome assembly;mRNA processing;negative regulation of defense response to virus;negative regulation of interferon-gamma production;negative regulation of interleukin-12 production;negative regulation of MDA-5 signaling pathway;negative regulation of mRNA splicing, via spliceosome;negative regulation of RIG-I signaling pathway;negative regulation of transcription from RNA polymerase II promoter;phosphatidylinositol 3-kinase signaling;positive regulation of apoptotic process;positive regulation of cell adhesion;positive regulation of dendritic cell chemotaxis;positive regulation of mitochondrial translation;positive regulation of neutrophil chemotaxis;positive regulation of protein kinase B signaling;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of trophoblast cell migration;regulation of complement activation;RNA splicing;transcription, DNA-templated;viral process","adrenergic receptor binding;complement component C1q binding;hyaluronic acid binding;kininogen binding;mitochondrial ribosome binding;mRNA binding;protein kinase C binding;transcription corepressor activity;transcription factor binding","cell surface;cytoplasm;cytosol;extracellular space;membrane;mitochondrial matrix;mitochondrion;nucleolus;nucleus;plasma membrane",{"$nulls":3},10,10,10,61,61,61,"31.362",0,"259.26",7996900000,258,"0.4209",1,"0.403204","1.11928","sp|Q07021|C1QBP_HUMAN;tr|I3L3Q7|I3L3Q7_HUMAN;tr|I3L3B0|I3L3B0_HUMAN","sp|Q07021|C1QBP_HUMAN;tr|I3L3Q7|I3L3Q7_HUMAN;tr|I3L3B0|I3L3B0_HUMAN",2117,"Q07021","C1QBP_HUMAN","Complement component 1 Q subcomponent-binding protein, mitochondrial",null,"C1QBP"]
["17.3076","16.9681","16.3729","17.0981",{"$nulls":3},"apoptotic process",null,"integral component of membrane;membrane",{"$nulls":3},4,4,4,"13.4","13.4","13.4","62.228",0,"13.01",106060000,17,"0.376052",1,"0.402369","1.00514","sp|Q96KA5|CLP1L_HUMAN;tr|G5E9Z2|G5E9Z2_HUMAN","sp|Q96KA5|CLP1L_HUMAN;tr|G5E9Z2|G5E9Z2_HUMAN",3754,"Q96KA5","CLP1L_HUMAN","Cleft lip and palate transmembrane protein 1-like protein","LPTM1-like protein","CLPTM1L"]
["19.922","20.5678","20.1155","19.5725",{"$nulls":3},"autophagosome assembly;cellular defense response;cilium assembly;craniofacial suture morphogenesis;GTP metabolic process;negative regulation of transcription factor import into nucleus;protein transport","GTP binding;GTPase activity","autophagosome;cell junction;centrosome;cytoplasm;cytosol;endosome membrane;extracellular exosome;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane",{"$nulls":3},4,4,4,"21.9","21.9","21.9","26.659",0,"12.483",144490000,18,"0.354281",1,"0.400882","0.950196","sp|Q9ULC3|RAB23_HUMAN","sp|Q9ULC3|RAB23_HUMAN",4807,"Q9ULC3","RAB23_HUMAN","Ras-related protein Rab-23",null,"RAB23"]
["16.3962","17.3269","15.6612","17.2643",{"$nulls":3},"apoptotic signaling pathway;transcription, DNA-templated","metal ion binding;RNA binding","cytoplasm;nucleus;spindle",{"$nulls":3},14,14,14,"10.2","10.2","10.2","243.87",0,"23.707",128090000,30,"0.149425",1,"0.398852","0.43034","sp|Q9BTC0|DIDO1_HUMAN","sp|Q9BTC0|DIDO1_HUMAN",3962,"Q9BTC0","DIDO1_HUMAN","Death-inducer obliterator 1","Dido1;IO-1","DIDO1"]
["23.2988","22.8809","23.5091","21.8762",{"$nulls":4},"ATP binding;SUMO transferase activity","cytosol",{"$nulls":3},5,5,5,"29.9","29.9","29.9","15.516",0,"11.304",570320000,41,"0.165074",1,"0.397238","0.471366","tr|H3BQQ9|H3BQQ9_HUMAN;sp|P63279|UBC9_HUMAN;tr|B0QYN7|B0QYN7_HUMAN;tr|H3BPC4|H3BPC4_HUMAN","tr|H3BQQ9|H3BQQ9_HUMAN;sp|P63279|UBC9_HUMAN;tr|B0QYN7|B0QYN7_HUMAN;tr|H3BPC4|H3BPC4_HUMAN",1950,"H3BQQ9","H3BQQ9_HUMAN",null,null,"UBE2I"]
["18.2646","18.1364","18.52","17.0935",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein export from nucleus;protein import into nucleus;protein sumoylation;regulation of cell cycle;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of mRNA stability;regulation of nucleocytoplasmic transport;RNA export from nucleus;tRNA export from nucleus;viral process;viral transcription","nuclear export signal receptor activity;nuclear localization sequence binding;structural constituent of nuclear pore","cytoplasmic side of nuclear pore;cytosol;focal adhesion;host cell;intracellular membrane-bounded organelle;nuclear pore central transport channel;nuclear pore nuclear basket;nucleoplasm;nucleus","RNA transport",null,null,16,16,16,"11.9","11.9","11.9","213.62",0,"43.181",219020000,42,"0.195441",1,"0.393763","0.549864","sp|P35658|NU214_HUMAN;tr|A0A0A0MSW3|A0A0A0MSW3_HUMAN;tr|H0Y837|H0Y837_HUMAN;tr|B7ZAV2|B7ZAV2_HUMAN;tr|E9PKD2|E9PKD2_HUMAN;tr|H0YF36|H0YF36_HUMAN","sp|P35658|NU214_HUMAN;tr|A0A0A0MSW3|A0A0A0MSW3_HUMAN",1395,"P35658","NU214_HUMAN","Nuclear pore complex protein Nup214",null,"NUP214"]
["21.5398","21.6171","20.6235","21.7505",{"$nulls":3},"cerebellar Purkinje cell layer development;hippocampus development;hypothalamus development;midbrain development;mitochondrial electron transport, ubiquinol to cytochrome c;pons development;pyramidal neuron development;subthalamus development;thalamus development","ubiquinol-cytochrome-c reductase activity","mitochondrial inner membrane;mitochondrial respiratory chain complex III;mitochondrion","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,6,6,6,"79.3","79.3","79.3","9.9062",0,"30.382",511070000,74,"0.251864",1,"0.39143","0.693065","sp|O14949|QCR8_HUMAN","sp|O14949|QCR8_HUMAN",303,"O14949","QCR8_HUMAN","Cytochrome b-c1 complex subunit 8",null,"UQCRQ"]
["23.6564","24.6342","23.9432","23.5647",{"$nulls":3},"actin filament organization;movement of cell or subcellular component;muscle contraction;muscle filament sliding;osteoblast differentiation","actin filament binding;calcium ion binding;identical protein binding;protein heterodimerization activity;protein homodimerization activity;structural constituent of muscle","actin filament;cortical cytoskeleton;cytoskeleton;cytosol;extracellular exosome;filamentous actin;focal adhesion;membrane;muscle thin filament tropomyosin;podosome;stress fiber","Adrenergic signaling in cardiomyocytes;Cardiac muscle contraction;Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM)",null,null,20,12,7,"59.7","39.9","27.8","28.521",0,"213.65",2173600000,95,"0.273137",1,"0.391384","0.746543","sp|P67936|TPM4_HUMAN;tr|K7EMU5|K7EMU5_HUMAN;tr|K7EPV9|K7EPV9_HUMAN;tr|K7EPB9|K7EPB9_HUMAN","sp|P67936|TPM4_HUMAN",1956,"P67936","TPM4_HUMAN","Tropomyosin alpha-4 chain",null,"TPM4"]
["19.6795","18.8278","19.689","18.0399",{"$nulls":3},"endocytosis;negative regulation of phosphatase activity","actin binding","actin filament;axon;early endosome;growth cone;membrane",{"$nulls":3},14,14,14,"19.4","19.4","19.4","133.63",0,"38.612",243340000,32,"0.14525",1,"0.389135","0.419314","sp|Q5T1M5|FKB15_HUMAN;tr|A0A0A0MT60|A0A0A0MT60_HUMAN;tr|X6RKW4|X6RKW4_HUMAN","sp|Q5T1M5|FKB15_HUMAN;tr|A0A0A0MT60|A0A0A0MT60_HUMAN",2721,"Q5T1M5","FKB15_HUMAN","FK506-binding protein 15","KBP-15","FKBP15"]
["21.5798","21.2713","21.7723","20.3025",{"$nulls":3},"cell differentiation;covalent chromatin modification;DNA replication-dependent nucleosome assembly;DNA replication-independent nucleosome assembly;multicellular organism development;regulation of transcription, DNA-templated;spermatogenesis;transcription, DNA-templated","histone binding","nuclear chromatin;nucleoplasm;protein complex",{"$nulls":3},5,4,4,"42.1","38.1","38.1","22.433",0,"69.714",511150000,43,"0.182624",1,"0.388137","0.516891","sp|Q9NVP2|ASF1B_HUMAN;tr|K7ES22|K7ES22_HUMAN;tr|K7ELW9|K7ELW9_HUMAN;tr|K7EIL9|K7EIL9_HUMAN;tr|K7EM93|K7EM93_HUMAN","sp|Q9NVP2|ASF1B_HUMAN;tr|K7ES22|K7ES22_HUMAN;tr|K7ELW9|K7ELW9_HUMAN",4498,"Q9NVP2","ASF1B_HUMAN","Histone chaperone ASF1B",null,"ASF1B"]
["20.1278","21.7525","20.6359","20.4759",{"$nulls":4},"ATPase activity, coupled to transmembrane movement of substances",{"$nulls":4},4,4,4,"27.6","27.6","27.6","21.921",0,"17.492",144450000,18,"0.164843",1,"0.384288","0.470765","tr|G3V2S6|G3V2S6_HUMAN;sp|Q9Y5K8|VATD_HUMAN;tr|H0YJ55|H0YJ55_HUMAN;tr|H0YJS0|H0YJS0_HUMAN;tr|G3V2V6|G3V2V6_HUMAN;tr|H0YJH8|H0YJH8_HUMAN;tr|G3V559|G3V559_HUMAN;tr|G3V5S7|G3V5S7_HUMAN;tr|G3V3T8|G3V3T8_HUMAN","tr|G3V2S6|G3V2S6_HUMAN;sp|Q9Y5K8|VATD_HUMAN;tr|H0YJ55|H0YJ55_HUMAN;tr|H0YJS0|H0YJS0_HUMAN;tr|G3V2V6|G3V2V6_HUMAN;tr|H0YJH8|H0YJH8_HUMAN;tr|G3V559|G3V559_HUMAN",5043,"G3V2S6","G3V2S6_HUMAN",null,null,"ATP6V1D"]
["21.0334","21.3555","21.012","20.6163",{"$nulls":3},"10-formyltetrahydrofolate catabolic process;biosynthetic process;folic acid metabolic process;one-carbon metabolic process","aldehyde dehydrogenase (NAD) activity;catalytic activity;formyltetrahydrofolate dehydrogenase activity;hydroxymethyl-, formyl- and related transferase activity","cytosol;extracellular exosome;mitochondrion","One carbon pool by folate",null,null,24,24,24,36,36,36,"98.828",0,"123.41",969620000,81,"0.561419",1,"0.380313","1.49071","sp|O75891|AL1L1_HUMAN;tr|C9JYZ6|C9JYZ6_HUMAN;tr|C9IZ36|C9IZ36_HUMAN;tr|C9JY00|C9JY00_HUMAN;tr|D6RFJ7|D6RFJ7_HUMAN;sp|Q3SY69|AL1L2_HUMAN","sp|O75891|AL1L1_HUMAN",623,"O75891","AL1L1_HUMAN","Cytosolic 10-formyltetrahydrofolate dehydrogenase","0-FTHFDH;DH","ALDH1L1"]
["21.4774","21.9611","21.4801","21.1998",{"$nulls":3},"cell separation after cytokinesis;endosomal transport;macroautophagy;membrane invagination;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of autophagosome assembly;negative regulation of neuron death;nucleus organization;plasma membrane tubulation;posttranslational protein targeting to endoplasmic reticulum membrane;protein homooligomerization;protein polymerization;vacuolar transport;vesicle budding from membrane;viral budding via host ESCRT complex;viral life cycle","ATPase binding;identical protein binding;lipid binding;protein homodimerization activity","cytoplasm;cytoplasmic side of plasma membrane;cytoplasmic vesicle membrane;cytosol;ESCRT III complex;extracellular exosome;late endosome membrane;membrane coat;midbody;nucleus","Endocytosis;Necroptosis",null,null,6,6,2,"35.1","35.1","11.3","25.098",0,"55.178",333400000,27,"0.51205",1,"0.379374","1.35725","sp|Q9BY43|CHM4A_HUMAN;tr|E9PQI5|E9PQI5_HUMAN;tr|E9PQ80|E9PQ80_HUMAN;tr|H0YI89|H0YI89_HUMAN;tr|H0YIN6|H0YIN6_HUMAN","sp|Q9BY43|CHM4A_HUMAN;tr|E9PQI5|E9PQI5_HUMAN;tr|E9PQ80|E9PQ80_HUMAN",4053,"Q9BY43","CHM4A_HUMAN","Charged multivesicular body protein 4a",null,"CHMP4A"]
["19.7523","19.1824","19.5731","18.603",{"$nulls":3},"copper ion homeostasis;Golgi to plasma membrane transport;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein localization to cell surface;negative regulation of sodium ion transmembrane transport;plasma membrane to endosome transport;positive regulation of protein ubiquitination;post-translational protein modification;protein transport;protein ubiquitination;regulation of proteasomal ubiquitin-dependent protein catabolic process;transcription, DNA-templated","copper ion binding;identical protein binding;phosphatidic acid binding;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-4,5-bisphosphate binding;protein homodimerization activity","Cul2-RING ubiquitin ligase complex;cytoplasm;cytosol;early endosome;endosome membrane;extracellular exosome;nucleoplasm;nucleus;recycling endosome",{"$nulls":3},3,3,3,"32.1","32.1","32.1","21.178","0.00026497","7.5669",55304000,7,"0.244376",1,"0.379298","0.674194","sp|Q8N668|COMD1_HUMAN;tr|E9PE85|E9PE85_HUMAN","sp|Q8N668|COMD1_HUMAN",3251,"Q8N668","COMD1_HUMAN","COMM domain-containing protein 1",null,"COMMD1"]
["15.5604","17.1207","15.7631","16.1638",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},4,3,3,"9.6","8.2","8.2","65.821",0,"13.028",22546000,8,"0.163846",1,"0.377101","0.468163","tr|A8MQB8|A8MQB8_HUMAN;tr|G3V0J0|G3V0J0_HUMAN;sp|Q06787|FMR1_HUMAN;tr|A0A087WXI3|A0A087WXI3_HUMAN;tr|G8JLE9|G8JLE9_HUMAN;tr|R9WNI0|R9WNI0_HUMAN;tr|Q8IXW7|Q8IXW7_HUMAN","tr|A8MQB8|A8MQB8_HUMAN;tr|G3V0J0|G3V0J0_HUMAN;sp|Q06787|FMR1_HUMAN;tr|A0A087WXI3|A0A087WXI3_HUMAN;tr|G8JLE9|G8JLE9_HUMAN;tr|R9WNI0|R9WNI0_HUMAN",5166,"A8MQB8","A8MQB8_HUMAN",null,null,"FMR1"]
["25.5824","26.567","25.9204","25.4752",{"$nulls":3},"membrane organization;negative regulation of ion transmembrane transport;negative regulation of transcription, DNA-templated;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein targeting;small GTPase mediated signal transduction;substantia nigra development","14-3-3 protein binding;identical protein binding;ion channel binding;protein C-terminus binding;protein domain specific binding;protein N-terminus binding","cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;focal adhesion;membrane;mitochondrion;protein complex","Cell cycle;Hepatitis B;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;Pathogenic Escherichia coli infection;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,15,11,11,58,"50.2","50.2","27.764",0,"323.31",8692300000,135,"0.253676",1,"0.376895","0.697627","sp|P27348|1433T_HUMAN;tr|E9PG15|E9PG15_HUMAN","sp|P27348|1433T_HUMAN;tr|E9PG15|E9PG15_HUMAN",1247,"P27348","1433T_HUMAN","14-3-3 protein theta",null,"YWHAQ"]
["19.1536","20.5862","19.2137","19.7736",{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;metal ion binding;RNA binding","catalytic step 2 spliceosome;nuclear matrix;nuclear speck;nucleoplasm;precatalytic spliceosome;U12-type spliceosomal complex;U2 snRNP","Spliceosome",null,null,3,3,3,"20.9","20.9","20.9","12.405","0.00067628","4.2639",56692000,4,"0.17195",1,"0.376266","0.489259","sp|Q7RTV0|PHF5A_HUMAN","sp|Q7RTV0|PHF5A_HUMAN",2983,"Q7RTV0","PHF5A_HUMAN","PHD finger-like domain-containing protein 5A","HD finger-like domain protein 5A","PHF5A"]
["22.4677","22.3675","22.7252","21.3629",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial membrane;mitochondrial respiratory chain complex I","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,4,4,4,"41.4","41.4","41.4","10.921",0,"11.954",269940000,20,"0.194261",1,"0.373487","0.546837","sp|O43678|NDUA2_HUMAN","sp|O43678|NDUA2_HUMAN",421,"O43678","NDUA2_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2",null,"NDUFA2"]
["22.079","22.3897","22.1583","21.5644",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;cellular response to glucagon stimulus;intracellular signal transduction;negative regulation of cAMP-dependent protein kinase activity;renal water homeostasis","cAMP binding;cAMP-dependent protein kinase inhibitor activity;cAMP-dependent protein kinase regulator activity;protein domain specific binding;protein kinase A catalytic subunit binding;ubiquitin protein ligase binding","cAMP-dependent protein kinase complex;centrosome;ciliary base;cytoplasm;cytosol;extracellular exosome;focal adhesion;membrane;nucleotide-activated protein kinase complex;plasma membrane;plasma membrane raft;protein complex","Insulin signaling pathway",null,null,14,14,14,45,45,45,"45.518",0,"117.52",907150000,81,"0.41853",1,"0.373025","1.11321","sp|P13861|KAP2_HUMAN;tr|H7C330|H7C330_HUMAN;tr|H7C1L0|H7C1L0_HUMAN;tr|C9J830|C9J830_HUMAN;sp|P31323|KAP3_HUMAN;tr|H7C4A9|H7C4A9_HUMAN","sp|P13861|KAP2_HUMAN",1036,"P13861","KAP2_HUMAN","cAMP-dependent protein kinase type II-alpha regulatory subunit",null,"PRKAR2A"]
["17.9089","17.3203","17.7004","16.7838",{"$nulls":3},"B cell differentiation;cell competition in a multicellular organism;histone H2A-T120 phosphorylation;negative regulation of transcription from RNA polymerase II promoter;protein ubiquitination;transcription, DNA-templated;V(D)J recombination;viral process","ATP binding;estrogen receptor binding;histone kinase activity (H2A-T120 specific)","Cul4-RING E3 ubiquitin ligase complex;cytoplasm;fibrillar center;nucleus","Human immunodeficiency virus 1 infection",null,null,3,3,3,"3.6","3.6","3.6","169.01",0,"13.57",121050000,18,"0.248243",1,"0.372523","0.683945","sp|Q9Y4B6|VPRBP_HUMAN","sp|Q9Y4B6|VPRBP_HUMAN",5010,"Q9Y4B6","DCAF1_HUMAN","DDB1- and CUL4-associated factor 1 {ECO:0000312|HGNC:HGNC:30911}",null,"DCAF1"]
["17.9161","17.3009","18.065","16.4116",{"$nulls":3},"calcium ion-regulated exocytosis of neurotransmitter;exocytosis;intracellular protein transport;regulation of calcium ion-dependent exocytosis;vesicle fusion","calcium ion binding;calcium-dependent phospholipid binding;clathrin binding;neurexin family protein binding;Rab GTPase binding;syntaxin binding","exocytic vesicle;extracellular exosome;extrinsic component of plasma membrane;melanosome;microvillus membrane;plasma membrane;presynapse",{"$nulls":3},9,9,9,"29.5","29.5","29.5","61.856",0,"24.276",313080000,37,"0.145404",1,"0.370226","0.419722","sp|Q8IYJ3|SYTL1_HUMAN;tr|A0A087X1N4|A0A087X1N4_HUMAN","sp|Q8IYJ3|SYTL1_HUMAN;tr|A0A087X1N4|A0A087X1N4_HUMAN",3167,"Q8IYJ3","SYTL1_HUMAN","Synaptotagmin-like protein 1",null,"SYTL1"]
["21.2892","20.8517","21.4616","19.9413",{"$nulls":3},"cell division;circadian regulation of gene expression;entrainment of circadian clock by photoperiod;G2/M transition of mitotic cell cycle;glycogen metabolic process;protein dephosphorylation;regulation of cell adhesion;regulation of circadian rhythm","metal ion binding;myosin phosphatase activity;myosin-light-chain-phosphatase activity;phosphatase activity;protein kinase binding","cytosol;extracellular exosome;focal adhesion;nucleolus;nucleoplasm;nucleus;PTW/PP1 phosphatase complex","Adrenergic signaling in cardiomyocytes;Alcoholism;Amphetamine addiction;cAMP signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Dopaminergic synapse;Focal adhesion;Herpes simplex virus 1 infection;Hippo signaling pathway;Inflammatory mediator regulation of TRP channels;Insulin resistance;Insulin signaling pathway;Long-term potentiation;mRNA surveillance pathway;Oocyte meiosis;Oxytocin signaling pathway;Platelet activation;Proteoglycans in cancer;Regulation of actin cytoskeleton;Vascular smooth muscle contraction",null,null,12,6,6,"49.2","30.6","30.6","37.186",0,"68.955",400370000,31,"0.163186",1,"0.368951","0.466441","sp|P62140|PP1B_HUMAN;tr|C9J9S3|C9J9S3_HUMAN;tr|C9JP48|C9JP48_HUMAN;tr|E7ETD8|E7ETD8_HUMAN","sp|P62140|PP1B_HUMAN;tr|C9J9S3|C9J9S3_HUMAN;tr|C9JP48|C9JP48_HUMAN;tr|E7ETD8|E7ETD8_HUMAN",1871,"P62140","PP1B_HUMAN","Serine/threonine-protein phosphatase PP1-beta catalytic subunit","P-1B;PP1CD","PPP1CB"]
["21.4545",1,1,"20.7177",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","RNA binding","cytosol;fibrillar center;mitochondrial inner membrane;mitochondrial ribosome;mitochondrion;nucleoplasm",{"$nulls":3},1,1,1,"13.6","13.6","13.6","13.475","0.00024155","5.625",129570000,21,"0.00803681",1,"0.368407","0.0259343","sp|Q96BP2|CHCH1_HUMAN","sp|Q96BP2|CHCH1_HUMAN",3616,"Q96BP2","CHCH1_HUMAN","Coiled-coil-helix-coiled-coil-helix domain-containing protein 1",null,"CHCHD1"]
["18.115","19.9969","18.0442","19.3346",{"$nulls":4},"nucleic acid binding",{"$nulls":4},4,4,4,"11.3","11.3","11.3","59.57",0,"11.424",164170000,24,"0.108747",1,"0.366508","0.321243","tr|A0A0A6YYC7|A0A0A6YYC7_HUMAN;sp|Q96JP5|ZFP91_HUMAN","tr|A0A0A6YYC7|A0A0A6YYC7_HUMAN;sp|Q96JP5|ZFP91_HUMAN",3747,"A0A0A6YYC7","A0A0A6YYC7_HUMAN",null,null,"ZFP91-CNTF"]
["21.3751","22.1775","21.3768","21.4482",{"$nulls":5},"cytosol;fibrillar center;nucleolus;plasma membrane",{"$nulls":3},2,2,2,"14.9","14.9","14.9","18.357",0,"24.366",111760000,21,"0.335617",1,"0.363803","0.903257","tr|J3KNE3|J3KNE3_HUMAN;sp|P68402|PA1B2_HUMAN","tr|J3KNE3|J3KNE3_HUMAN;sp|P68402|PA1B2_HUMAN",1964,"J3KNE3","J3KNE3_HUMAN",null,null,"PAFAH1B2"]
["18.5795","18.8182","18.8436","17.8322",{"$nulls":3},"nervous system development","heparin binding;transition metal ion binding","integral component of membrane",{"$nulls":3},5,5,5,"10.8","10.8","10.8","75.109",0,"20.113",120700000,17,"0.252488",1,"0.360936","0.694638","tr|A0A0A0MRG2|A0A0A0MRG2_HUMAN;tr|E9PG40|E9PG40_HUMAN;sp|P05067|A4_HUMAN;tr|H7C0V9|H7C0V9_HUMAN;sp|Q06481|APLP2_HUMAN","tr|A0A0A0MRG2|A0A0A0MRG2_HUMAN;tr|E9PG40|E9PG40_HUMAN;sp|P05067|A4_HUMAN;tr|H7C0V9|H7C0V9_HUMAN",854,"A0A0A0MRG2","A0A0A0MRG2_HUMAN",null,null,"APP"]
["20.985","20.152","20.8044","19.6174",{"$nulls":3},"fucose metabolic process;glycolipid catabolic process;glycosaminoglycan catabolic process;glycoside catabolic process;neutrophil degranulation","alpha-L-fucosidase activity","azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;lysosomal lumen","Lysosome;Other glycan degradation",null,null,7,7,7,"22.7","22.7","22.7","53.688",0,"83.609",300240000,33,"0.173446",1,"0.357549","0.493143","sp|P04066|FUCO_HUMAN","sp|P04066|FUCO_HUMAN",831,"P04066","FUCO_HUMAN","Tissue alpha-L-fucosidase",null,"FUCA1"]
["20.6931","21.3362","20.7604","20.5565",{"$nulls":3},"activation of protein kinase activity;apoptotic process;cytoplasmic microtubule organization;protein autophosphorylation;regulation of apoptotic process;regulation of cell migration;regulation of focal adhesion assembly;regulation of mitotic cell cycle;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;cadherin binding;identical protein binding;protein homodimerization activity;protein serine/threonine kinase activity","cell leading edge;cytoplasm;extracellular exosome;perinuclear region of cytoplasm","Oocyte meiosis",null,null,31,31,31,"35.7","35.7","35.7","142.69",0,"122.55",1128800000,130,"0.396081",1,"0.356199","1.05593","sp|Q9H2G2|SLK_HUMAN","sp|Q9H2G2|SLK_HUMAN",4169,"Q9H2G2","SLK_HUMAN","STE20-like serine/threonine-protein kinase","SLK;TE20-like kinase","SLK"]
["16.7316",1,"16.0208",1,{"$nulls":3},"cell differentiation;cell migration;innate immune response;negative regulation of cell growth;negative regulation of Ras protein signal transduction;peptidyl-tyrosine autophosphorylation;protein autophosphorylation;protein phosphorylation;regulation of cell proliferation;transmembrane receptor protein tyrosine kinase signaling pathway","ATP binding;non-membrane spanning protein tyrosine kinase activity;protein tyrosine kinase activity;receptor binding;signal transducer activity","cytoplasm;cytosol;extrinsic component of cytoplasmic side of plasma membrane;membrane",{"$nulls":3},3,3,3,"4.7","4.7","4.7","72.467","0.00067009","4.1401",35221000,7,"0.0101508",1,"0.355411","0.0326799","sp|Q13470|TNK1_HUMAN;tr|I3L334|I3L334_HUMAN","sp|Q13470|TNK1_HUMAN;tr|I3L334|I3L334_HUMAN",2263,"Q13470","TNK1_HUMAN","Non-receptor tyrosine-protein kinase TNK1",null,"TNK1"]
["15.5991",1,"14.8897",1,{"$nulls":4},"metal ion binding;ubiquitin-protein transferase activity","LUBAC complex",{"$nulls":3},2,2,2,"3.7","3.7","3.7","102.29","0.0087176","2.3105",6007000,3,"0.0109441",1,"0.354688","0.0352033","tr|H0YKX0|H0YKX0_HUMAN;sp|Q96EP0|RNF31_HUMAN;tr|A0A0B4J293|A0A0B4J293_HUMAN","tr|H0YKX0|H0YKX0_HUMAN;sp|Q96EP0|RNF31_HUMAN;tr|A0A0B4J293|A0A0B4J293_HUMAN",3668,"H0YKX0","H0YKX0_HUMAN",null,null,"RNF31"]
["20.6619","21.62","20.6665","20.9125",{"$nulls":3},"cell proliferation;cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);regulation of cell cycle;regulation of signal transduction by p53 class mediator;ribosomal large subunit assembly;ribosome biogenesis;rRNA processing","ribonucleoprotein complex binding;RNA binding","intracellular ribonucleoprotein complex;nucleolus;nucleoplasm;nucleus;PeBoW complex;preribosome, large subunit precursor",{"$nulls":3},24,24,24,"44.8","44.8","44.8","83.629",0,"323.31",2411800000,147,"0.258831",1,"0.351449","0.710598","sp|Q14137|BOP1_HUMAN;tr|A0A075B729|A0A075B729_HUMAN","sp|Q14137|BOP1_HUMAN",2330,"Q14137","BOP1_HUMAN","Ribosome biogenesis protein BOP1 {ECO:0000255|HAMAP-Rule:MF_03027}",null,"BOP1"]
["21.5064","21.7711","21.0324","21.5448",{"$nulls":3},"covalent chromatin modification;positive regulation of rRNA processing;regulation of transcription, DNA-templated;rRNA (guanine-N7)-methylation;rRNA methylation;transcription, DNA-templated","methyltransferase activity;protein heterodimerization activity;RNA binding;rRNA (guanine) methyltransferase activity","nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},7,7,7,"28.1","28.1","28.1","31.88",0,"24.571",477260000,57,"0.457749",1,"0.350151","1.21435","sp|O43709|WBS22_HUMAN;tr|F8VZ18|F8VZ18_HUMAN;tr|F8WD87|F8WD87_HUMAN;tr|B3KR83|B3KR83_HUMAN;tr|H7C170|H7C170_HUMAN;tr|F8WD67|F8WD67_HUMAN;tr|E9PCQ7|E9PCQ7_HUMAN;tr|F2Z3D9|F2Z3D9_HUMAN;tr|H7C0G4|H7C0G4_HUMAN","sp|O43709|WBS22_HUMAN",426,"O43709","BUD23_HUMAN","Probable 18S rRNA (guanine-N(7))-methyltransferase {ECO:0000305}",null,"BUD23"]
["17.2268","14.3746","17.4577","13.4454",{"$nulls":3},"protein import into nucleus","DNA binding;metal ion binding;protein phosphatase inhibitor activity;RNA binding","chromatin;nuclear body;nucleoplasm;nucleus;PTW/PP1 phosphatase complex",{"$nulls":3},5,5,5,"6.8","6.8","6.8","99.057",0,"26.414",82735000,12,"0.0456603",1,"0.349131","0.141845","sp|Q96QC0|PP1RA_HUMAN","sp|Q96QC0|PP1RA_HUMAN",3792,"Q96QC0","PP1RA_HUMAN","Serine/threonine-protein phosphatase 1 regulatory subunit 10",null,"PPP1R10"]
["20.2326","21.176","20.3174","20.3948",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;antigen processing and presentation, exogenous lipid antigen via MHC class Ib;blood coagulation;intracellular protein transport;melanosome organization;positive regulation of NK T cell differentiation;protein targeting to lysosome","GTP-dependent protein binding;protein phosphatase binding","AP-3 adaptor complex;axon cytoplasm;clathrin adaptor complex;clathrin-coated vesicle membrane;Golgi apparatus;lysosomal membrane;membrane","Lysosome",null,null,46,46,36,"49.6","49.6","41.2","121.32",0,"323.31",9858600000,575,"0.268822",1,"0.348221","0.735709","sp|O00203|AP3B1_HUMAN;tr|H0YBD0|H0YBD0_HUMAN;tr|F5GWU4|F5GWU4_HUMAN;tr|F5GYB0|F5GYB0_HUMAN","sp|O00203|AP3B1_HUMAN",201,"O00203","AP3B1_HUMAN","AP-3 complex subunit beta-1",null,"AP3B1"]
["22.6591","22.2254","22.4764","21.7182",{"$nulls":3},"cell cycle;cell division","RNA binding","cytoplasm;microtubule organizing center;midbody",{"$nulls":3},15,15,15,"47.5","47.5","47.5","25.835",0,"111.95",2596400000,140,"0.290411",1,"0.344939","0.789875","sp|Q96CT7|CC124_HUMAN;tr|M0R2F5|M0R2F5_HUMAN","sp|Q96CT7|CC124_HUMAN",3641,"Q96CT7","CC124_HUMAN","Coiled-coil domain-containing protein 124",null,"CCDC124"]
["19.4691","19.2345","19.8719","18.1452",{"$nulls":3},"metal ion transport","metal ion binding;superoxide dismutase activity",{"$nulls":4},3,3,3,"11.8","11.8","11.8","27.086","0.00023624","5.1745",75906000,4,"0.135698",1,"0.343246","0.393959","tr|J3KNF4|J3KNF4_HUMAN;sp|O14618|CCS_HUMAN;tr|E9PP76|E9PP76_HUMAN;tr|E9PK03|E9PK03_HUMAN","tr|J3KNF4|J3KNF4_HUMAN;sp|O14618|CCS_HUMAN;tr|E9PP76|E9PP76_HUMAN",266,"J3KNF4","J3KNF4_HUMAN",null,null,"CCS"]
["23.5154","23.0299","22.6136","23.2502",{"$nulls":3},"ketone body biosynthetic process;ketone body catabolic process","3-hydroxybutyrate dehydrogenase activity","matrix side of mitochondrial inner membrane;mitochondrial matrix;mitochondrion;nucleoplasm","Butanoate metabolism;Metabolic pathways;Synthesis and degradation of ketone bodies",null,null,11,11,11,"45.2","45.2","45.2","38.157",0,"131.09",2409000000,102,"0.314904",1,"0.340768","0.851279","sp|Q02338|BDH_HUMAN;tr|E9PCG9|E9PCG9_HUMAN;tr|C9K0G7|C9K0G7_HUMAN;tr|C9JM78|C9JM78_HUMAN;tr|C9JQ90|C9JQ90_HUMAN;tr|A0A0G2JRX6|A0A0G2JRX6_HUMAN;tr|H7C2W1|H7C2W1_HUMAN;tr|C9JEB9|C9JEB9_HUMAN","sp|Q02338|BDH_HUMAN;tr|E9PCG9|E9PCG9_HUMAN;tr|C9K0G7|C9K0G7_HUMAN;tr|C9JM78|C9JM78_HUMAN;tr|C9JQ90|C9JQ90_HUMAN;tr|A0A0G2JRX6|A0A0G2JRX6_HUMAN",2067,"Q02338","BDH_HUMAN","D-beta-hydroxybutyrate dehydrogenase, mitochondrial {ECO:0000305}",null,"BDH1"]
["21.4855","21.8038","21.6835","20.9259",{"$nulls":3},"protein transport;regulation of ER to Golgi vesicle-mediated transport;vesicle-mediated transport",null,"COPII-coated ER to Golgi transport vesicle;endoplasmic reticulum;endoplasmic reticulum exit site;endoplasmic reticulum membrane;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},1,1,1,"4.7","4.7","4.7","27.989","0.00023452","5.0083",70651000,8,"0.305333",1,"0.339955","0.827284","sp|Q969M3|YIPF5_HUMAN","sp|Q969M3|YIPF5_HUMAN",3578,"Q969M3","YIPF5_HUMAN","Protein YIPF5",null,"YIPF5"]
["17.977","17.1","17.3966","17.0013",{"$nulls":3},"lipid metabolic process;long-chain fatty-acyl-CoA metabolic process;wax biosynthetic process","alcohol-forming fatty acyl-CoA reductase activity;fatty-acyl-CoA reductase (alcohol-forming) activity;oxidoreductase activity","integral component of peroxisomal membrane;peroxisomal matrix;peroxisome","Peroxisome",null,null,14,14,14,"32.6","32.6","32.6","59.438",0,"130.39",1038200000,90,"0.256994",1,"0.339545","0.705977","sp|Q96K12|FACR2_HUMAN;tr|F8VX60|F8VX60_HUMAN;tr|H0YIE0|H0YIE0_HUMAN;tr|F8VPF2|F8VPF2_HUMAN","sp|Q96K12|FACR2_HUMAN",3748,"Q96K12","FACR2_HUMAN","Fatty acyl-CoA reductase 2 {ECO:0000305|PubMed:15220348}",null,"FAR2"]
["19.4349","19.8174","19.6564","18.92",{"$nulls":3},"positive regulation of gene expression, epigenetic;rRNA transcription;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription initiation from RNA polymerase I promoter;transmembrane receptor protein tyrosine kinase signaling pathway","DNA-directed 5'-3' RNA polymerase activity;RNA binding","chromosome;cytosol;fibrillar center;mitochondrion;nucleolus;nucleoplasm;nucleus;RNA polymerase I transcription factor complex",{"$nulls":3},16,16,16,"53.3","53.3","53.3","54.985",0,"168.35",1890200000,191,"0.300246",1,"0.33794","0.81453","sp|O15446|RPA34_HUMAN","sp|O15446|RPA34_HUMAN",365,"O15446","RPA34_HUMAN","DNA-directed RNA polymerase I subunit RPA34",null,"CD3EAP"]
["20.7539","19.6681","21.0263","18.7249",{"$nulls":3},"electron transport chain;fatty acid beta-oxidation using acyl-CoA dehydrogenase;respiratory electron transport chain;response to oxidative stress","4 iron, 4 sulfur cluster binding;electron transfer activity;electron-transferring-flavoprotein dehydrogenase activity;flavin adenine dinucleotide binding;metal ion binding;oxidoreductase activity;oxidoreductase activity, oxidizing metal ions with flavin as acceptor;quinone binding;ubiquinone binding","integral component of mitochondrial inner membrane;mitochondrial electron transfer flavoprotein complex;mitochondrial matrix;mitochondrial membrane",{"$nulls":3},8,8,8,"16.9","16.9","16.9","68.495",0,"20.756",321410000,22,"0.0879048",1,"0.335397","0.263602","sp|Q16134|ETFD_HUMAN;tr|D6RAD5|D6RAD5_HUMAN","sp|Q16134|ETFD_HUMAN",2535,"Q16134","ETFD_HUMAN","Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial","TF-QO;TF-ubiquinone oxidoreductase","ETFDH"]
["20.3753","20.8025","20.4969","20.0135",{"$nulls":3},"ubiquitin-dependent protein catabolic process","ubiquitin protein ligase binding","cullin-RING ubiquitin ligase complex;cytosol;nucleoplasm",{"$nulls":3},17,17,13,"24.9","24.9","20.2","102.75",0,"111.54",672810000,56,"0.387666",1,"0.333709","1.03456","tr|K4DI93|K4DI93_HUMAN;sp|Q13620|CUL4B_HUMAN;tr|A6NE76|A6NE76_HUMAN","tr|K4DI93|K4DI93_HUMAN;sp|Q13620|CUL4B_HUMAN",2295,"K4DI93","K4DI93_HUMAN"]
["12.3014",1,"11.6383",1,{"$nulls":3},"activation of MAPKK activity;cellular response to nerve growth factor stimulus;dendrite morphogenesis;in utero embryonic development;nerve growth factor signaling pathway;positive regulation of neuron projection development;regulation of protein kinase activity","PDZ domain binding;protein kinase regulator activity","cytosol;integral component of membrane;late endosome;membrane;protein complex","Neurotrophin signaling pathway",null,null,6,6,6,"4.5","4.5","4.5","196.54",0,"17.43",53173000,18,"0.0133178",1,"0.331592","0.0427288","sp|Q9ULH0|KDIS_HUMAN;tr|E9PH70|E9PH70_HUMAN;tr|H0Y8E4|H0Y8E4_HUMAN;tr|F8WAY8|F8WAY8_HUMAN","sp|Q9ULH0|KDIS_HUMAN;tr|E9PH70|E9PH70_HUMAN;tr|H0Y8E4|H0Y8E4_HUMAN",4816,"Q9ULH0","KDIS_HUMAN","Kinase D-interacting substrate of 220 kDa",null,"KIDINS220"]
["16.6716","17.9979","17.0253","16.982",{"$nulls":3},"endomembrane system organization;exocytosis;Golgi organization;negative regulation of actin filament polymerization;negative regulation of GTPase activity;neuron projection development;positive regulation of protein glycosylation in Golgi;positive regulation of protein kinase B signaling;positive regulation of wound healing;protein transport;regulation of ARF protein signal transduction;regulation of establishment of cell polarity","ARF guanyl-nucleotide exchange factor activity;guanyl-nucleotide exchange factor activity;myosin binding;protein kinase A regulatory subunit binding","cytosol;Golgi apparatus;Golgi membrane;nuclear matrix;nucleolus;nucleoplasm;perinuclear region of cytoplasm;small nuclear ribonucleoprotein complex;trans-Golgi network","Endocytosis",null,null,12,12,9,"8.6","8.6","7.1","208.76",0,"27.05",201000000,29,"0.175713",1,"0.331091","0.499019","sp|Q9Y6D6|BIG1_HUMAN;tr|E5RIF2|E5RIF2_HUMAN;tr|E5RHL7|E5RHL7_HUMAN;tr|E5RHZ1|E5RHZ1_HUMAN","sp|Q9Y6D6|BIG1_HUMAN;tr|E5RIF2|E5RIF2_HUMAN",5089,"Q9Y6D6","BIG1_HUMAN","Brefeldin A-inhibited guanine nucleotide-exchange protein 1","refeldin A-inhibited GEP 1","ARFGEF1"]
["22.0873","22.5538","22.1077","21.8754",{"$nulls":3},"aerobic respiration;mitochondrial calcium ion transmembrane transport;mitochondrial electron transport, ubiquinol to cytochrome c;protein processing","metalloendopeptidase activity;zinc ion binding","mitochondrial inner membrane;mitochondrial matrix;mitochondrial respiratory chain complex III;mitochondrion",{"$nulls":3},14,13,13,38,"36.6","36.6","54.366",0,"138.01",884530000,61,"0.476268",1,"0.329011","1.26268","sp|O75439|MPPB_HUMAN;tr|G3V0E4|G3V0E4_HUMAN;tr|F8WAZ6|F8WAZ6_HUMAN;tr|F8WEA6|F8WEA6_HUMAN;tr|F8WBE1|F8WBE1_HUMAN","sp|O75439|MPPB_HUMAN;tr|G3V0E4|G3V0E4_HUMAN",570,"O75439","MPPB_HUMAN","Mitochondrial-processing peptidase subunit beta",null,"PMPCB"]
["18.8089","18.1132","19.1043","17.16",{"$nulls":3},"apoptotic process;cell migration;phagocytosis","SH3 domain binding","cytoplasm","Bacterial invasion of epithelial cells;Shigellosis",null,null,7,7,7,"16.5","16.5","16.5","81.466",0,"29.464",177870000,32,"0.107743",1,"0.328844","0.318497","sp|Q96BJ8|ELMO3_HUMAN;tr|F8W9E7|F8W9E7_HUMAN;tr|I3L4D1|I3L4D1_HUMAN","sp|Q96BJ8|ELMO3_HUMAN;tr|F8W9E7|F8W9E7_HUMAN",3612,"Q96BJ8","ELMO3_HUMAN","Engulfment and cell motility protein 3",null,"ELMO3"]
["19.3963","18.3136","19.1942","17.8596",{"$nulls":3},"DNA replication;DNA replication initiation;G1/S transition of mitotic cell cycle;protein import into nucleus, translocation;telomere maintenance via semi-conservative replication","DNA binding;DNA-directed DNA polymerase activity;protein heterodimerization activity","alpha DNA polymerase:primase complex;cytosol;nucleoplasm","DNA replication",null,null,6,6,6,"17.7","17.7","17.7","65.947",0,"13.503",103680000,14,"0.13114",1,"0.328058","0.381785","sp|Q14181|DPOA2_HUMAN;tr|E9PIQ6|E9PIQ6_HUMAN;tr|H0YDR7|H0YDR7_HUMAN","sp|Q14181|DPOA2_HUMAN;tr|E9PIQ6|E9PIQ6_HUMAN",2342,"Q14181","DPOA2_HUMAN","DNA polymerase alpha subunit B",null,"POLA2"]
["21.3961","21.2452","21.7614","20.2264",{"$nulls":3},"axon extension;behavioral response to cocaine;calcium ion import;cell cycle;cell division;cell proliferation;cell-matrix adhesion;cellular response to amyloid-beta;central nervous system neuron development;cerebellar cortex formation;chemical synaptic transmission;corpus callosum development;cortical actin cytoskeleton organization;dendrite morphogenesis;excitatory postsynaptic potential;hippocampus development;intracellular protein transport;layer formation in cerebral cortex;microtubule cytoskeleton organization;motor neuron axon guidance;negative regulation of axon extension;negative regulation of cell cycle;negative regulation of neuron death;negative regulation of protein export from nucleus;negative regulation of protein ubiquitination;negative regulation of proteolysis;negative regulation of synaptic plasticity;negative regulation of transcription, DNA-templated;neuron apoptotic process;neuron differentiation;neuron migration;neuron projection development;nucleocytoplasmic transport;oligodendrocyte differentiation;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;phosphorylation;positive regulation of actin cytoskeleton reorganization;positive regulation of calcium ion-dependent exocytosis;positive regulation of neuron apoptotic process;positive regulation of protein binding;positive regulation of protein kinase activity;positive regulation of protein targeting to membrane;protein autophosphorylation;protein localization to synapse;protein phosphorylation;receptor catabolic process;receptor clustering;regulation of apoptotic process;regulation of cell cycle arrest;regulation of cell migration;regulation of dendritic spine morphogenesis;regulation of macroautophagy;regulation of protein localization to plasma membrane;regulation of signal transduction by p53 class mediator;regulation of synaptic plasticity;regulation of synaptic transmission, glutamatergic;regulation of synaptic vesicle recycling;response to wounding;rhythmic process;Schwann cell development;sensory perception of pain;serine phosphorylation of STAT protein;skeletal muscle tissue development;synapse assembly;synaptic transmission, dopaminergic;synaptic transmission, glutamatergic;synaptic vesicle endocytosis;synaptic vesicle exocytosis;visual learning","acetylcholine receptor activator activity;ATP binding;cyclin-dependent protein serine/threonine kinase activity;cytoskeletal protein binding;ephrin receptor binding;ErbB-2 class receptor binding;ErbB-3 class receptor binding;kinase activity;p53 binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;tau-protein kinase activity","axon;cell junction;cyclin-dependent protein kinase 5 holoenzyme complex;cytoplasm;cytosol;dendrite;filopodium;growth cone;lamellipodium;membrane;microtubule;neuromuscular junction;neuronal cell body;nucleoplasm;nucleus;perikaryon;plasma membrane;postsynaptic density;postsynaptic membrane;presynapse","Alzheimer disease;Axon guidance;Cocaine addiction",null,null,12,11,11,"40.4","37.7","37.7","33.304",0,"32.173",751250000,70,"0.146904",1,"0.326763","0.423688","sp|Q00535|CDK5_HUMAN","sp|Q00535|CDK5_HUMAN",2031,"Q00535","CDK5_HUMAN","Cyclin-dependent-like kinase 5",null,"CDK5"]
["20.7737","21.3737","21.1436","20.3573",{"$nulls":3},"actin filament bundle assembly;apoptotic process;apoptotic signaling pathway;interleukin-2 biosynthetic process;negative regulation of B cell proliferation;negative regulation of fibroblast proliferation;negative regulation of T cell proliferation;negative regulation of T cell receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;positive regulation of amyloid precursor protein biosynthetic process;positive regulation of apoptotic process;positive regulation of cellular senescence;positive regulation of gene expression;positive regulation of hydrogen peroxide-mediated programmed cell death;transcription, DNA-templated","actin binding;enzyme binding;leucine zipper domain binding;transcription corepressor activity","actin filament;cytoplasm;nuclear chromatin;nucleus",{"$nulls":3},5,5,5,"24.4","24.4","24.4","36.567",0,"29.121",214780000,23,"0.236238",1,"0.323233","0.653649","sp|Q96IZ0|PAWR_HUMAN;tr|A0A0B4J260|A0A0B4J260_HUMAN;tr|F8W1M8|F8W1M8_HUMAN;tr|H0YI16|H0YI16_HUMAN","sp|Q96IZ0|PAWR_HUMAN",3737,"Q96IZ0","PAWR_HUMAN","PRKC apoptosis WT1 regulator protein",null,"PAWR"]
["19.6821","20.3948","19.8628","19.5683",{"$nulls":4},"peptidase activity",{"$nulls":4},5,5,5,27,27,27,"32.132",0,"14.187",123320000,21,"0.309389",1,"0.322898","0.83745","tr|D6R9T3|D6R9T3_HUMAN;tr|E7EMP6|E7EMP6_HUMAN;sp|Q96FZ2|HMCES_HUMAN;tr|D6RGK7|D6RGK7_HUMAN;tr|D6RAI0|D6RAI0_HUMAN;tr|D6RAZ3|D6RAZ3_HUMAN","tr|D6R9T3|D6R9T3_HUMAN;tr|E7EMP6|E7EMP6_HUMAN;sp|Q96FZ2|HMCES_HUMAN;tr|D6RGK7|D6RGK7_HUMAN;tr|D6RAI0|D6RAI0_HUMAN;tr|D6RAZ3|D6RAZ3_HUMAN",3688,"D6R9T3","D6R9T3_HUMAN","Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein {ECO:0000256|RuleBase:RU364100}","S cell-specific 5hmC-binding protein {ECO:0000256|RuleBase:RU364100}","HMCES"]
["21.5118","22.7629","21.6705","21.9607",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding;U6 snRNA binding","nucleoplasm;precatalytic spliceosome;U4/U6 x U5 tri-snRNP complex;U6 snRNP","RNA degradation;Spliceosome",null,null,4,4,4,"46.9","46.9","46.9","10.403",0,"11.561",248470000,12,"0.17648",1,"0.321749","0.501007","sp|O95777|LSM8_HUMAN;tr|F2Z2Y6|F2Z2Y6_HUMAN;tr|C9JIZ0|C9JIZ0_HUMAN;tr|C9JNV3|C9JNV3_HUMAN","sp|O95777|LSM8_HUMAN;tr|F2Z2Y6|F2Z2Y6_HUMAN;tr|C9JIZ0|C9JIZ0_HUMAN;tr|C9JNV3|C9JNV3_HUMAN",762,"O95777","LSM8_HUMAN","U6 snRNA-associated Sm-like protein LSm8",null,"LSM8"]
["21.7349","22.5307","22.0253","21.5974",{"$nulls":3},"calcium ion regulated exocytosis;cerebellum development;fat cell differentiation;response to ethanol;UV protection;zymogen granule exocytosis","calcium ion binding;identical protein binding","bleb;cytoplasm;extracellular exosome;Golgi apparatus;Golgi lumen;late endosome;membrane;plasma membrane",{"$nulls":3},13,13,13,"50.6","50.6","50.6","41.806",0,"246.89",724480000,49,"0.259171",1,"0.321424","0.711455","sp|Q9BRK5|CAB45_HUMAN;tr|H0Y3T6|H0Y3T6_HUMAN;tr|G3V1E2|G3V1E2_HUMAN","sp|Q9BRK5|CAB45_HUMAN;tr|H0Y3T6|H0Y3T6_HUMAN;tr|G3V1E2|G3V1E2_HUMAN",3934,"Q9BRK5","CAB45_HUMAN","45 kDa calcium-binding protein","ab45","SDF4"]
["20.8904","21.1405","20.9582","20.4354",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular signal transduction;protein phosphorylation;transcription initiation from RNA polymerase II promoter","ATP binding;protein homodimerization activity;protein serine/threonine kinase activity","cell cortex;cytosol;endomembrane system;lamellipodium;membrane;nucleoplasm",{"$nulls":3},9,9,9,"25.2","25.2","25.2","59.844",0,"54.798",310490000,20,"0.413327",1,"0.318663","1.09989","sp|Q9UHY1|NRBP_HUMAN;tr|F8W6G1|F8W6G1_HUMAN;tr|C9JHZ6|C9JHZ6_HUMAN;tr|C9JDW7|C9JDW7_HUMAN","sp|Q9UHY1|NRBP_HUMAN;tr|F8W6G1|F8W6G1_HUMAN",4741,"Q9UHY1","NRBP_HUMAN","Nuclear receptor-binding protein",null,"NRBP1"]
["20.845","24.6198","20.6089","24.2187",{"$nulls":3},"cholesterol biosynthetic process;cholesterol biosynthetic process via desmosterol;cholesterol biosynthetic process via lathosterol;cholesterol metabolic process;hemopoiesis;skeletal system development","C-8 sterol isomerase activity;cholestenol delta-isomerase activity;drug transmembrane transporter activity;steroid delta-isomerase activity;transmembrane signaling receptor activity","cytoplasmic vesicle;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of plasma membrane;nuclear envelope","Metabolic pathways;Steroid biosynthesis",null,null,2,2,2,"12.2","12.2","12.2","26.352",0,"12.668",944750000,25,"0.0390286",1,"0.318599","0.121999","sp|Q15125|EBP_HUMAN;tr|C9J719|C9J719_HUMAN;tr|C9JJ78|C9JJ78_HUMAN","sp|Q15125|EBP_HUMAN;tr|C9J719|C9J719_HUMAN;tr|C9JJ78|C9JJ78_HUMAN",2453,"Q15125","EBP_HUMAN","3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase",null,"EBP"]
["17.2593","17.6699","17.6733","16.6297",{"$nulls":3},"base-excision repair;cellular response to DNA damage stimulus;cellular response to UV;monoubiquitinated protein deubiquitination;negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of transcription, DNA-templated;positive regulation of canonical Wnt signaling pathway;positive regulation of cell growth;protein deubiquitination;response to drug;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitinyl hydrolase activity;WD40-repeat domain binding","cytoplasm;nucleoplasm;SCF ubiquitin ligase complex",{"$nulls":3},9,9,9,"9.2","9.2","9.2","157.31",0,"32.908",120750000,19,"0.198772",1,"0.313109","0.558401","sp|Q96K76|UBP47_HUMAN","sp|Q96K76|UBP47_HUMAN",3753,"Q96K76","UBP47_HUMAN","Ubiquitin carboxyl-terminal hydrolase 47",null,"USP47"]
["18.134","19.2578","17.6013","19.1658",{"$nulls":3},"negative regulation of retrograde protein transport, ER to cytosol;protein localization to endoplasmic reticulum","ubiquitin binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},3,3,3,"13.1","13.1","13.1","38.963",0,"17.124",126820000,26,"0.109861",1,"0.312333","0.324286","sp|Q8NBM4|UBAC2_HUMAN;tr|X6R5E5|X6R5E5_HUMAN","sp|Q8NBM4|UBAC2_HUMAN;tr|X6R5E5|X6R5E5_HUMAN",3287,"Q8NBM4","UBAC2_HUMAN","Ubiquitin-associated domain-containing protein 2","BA domain-containing protein 2","UBAC2"]
["19.6194","19.4664","19.5174","18.9471",{"$nulls":3},"autophagosome maturation;autophagosome membrane docking;cilium assembly;exocytosis;membrane fusion;neutrophil degranulation;protein transport;synaptic vesicle fusion to presynaptic active zone membrane;synaptic vesicle priming;vesicle targeting","SNAP receptor activity;syntaxin binding","autophagosome;autophagosome membrane;azurophil granule membrane;centrosome;ciliary pocket membrane;cytoplasm;cytosol;Golgi membrane;nucleoplasm;plasma membrane;presynapse;SNARE complex","Autophagy - animal;SNARE interactions in vesicular transport",null,null,5,5,5,"23.6","23.6","23.6","28.97",0,"8.8083",78912000,6,"0.394613",1,"0.310662","1.0522","sp|O95721|SNP29_HUMAN;tr|C9JAF7|C9JAF7_HUMAN","sp|O95721|SNP29_HUMAN;tr|C9JAF7|C9JAF7_HUMAN",757,"O95721","SNP29_HUMAN","Synaptosomal-associated protein 29 {ECO:0000312|HGNC:HGNC:11133}","NAP-29 {ECO:0000312|HGNC:HGNC:11133}","SNAP29"]
["21.5894","21.7417","21.3983","21.3131",{"$nulls":3},"ADP transport;apoptotic mitochondrial changes;generation of precursor metabolites and energy;mitochondrial genome maintenance;negative regulation of necroptotic process;regulation of insulin secretion;regulation of mitochondrial membrane permeability;transport;viral process","adenine transmembrane transporter activity;ATP:ADP antiporter activity","integral component of mitochondrial membrane;integral component of plasma membrane;mitochondrial inner membrane;mitochondrion;myelin sheath;nucleus","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Necroptosis;Parkinson disease",null,null,15,4,4,"51.3","13.4","13.4","33.064",0,"15.606",1221600000,48,"1.14927",1,"0.309886","3.55245","sp|P12235|ADT1_HUMAN;tr|V9GYG0|V9GYG0_HUMAN","sp|P12235|ADT1_HUMAN;tr|V9GYG0|V9GYG0_HUMAN",1009,"P12235","ADT1_HUMAN","ADP/ATP translocase 1",null,"SLC25A4"]
["19.9548","20.5595","20.1571","19.7389",{"$nulls":9},11,11,11,"25.9","25.9","25.9","64.705",0,"45.165",322410000,39,"0.310762",1,"0.309131","0.840892","tr|A0A087WWS7|A0A087WWS7_HUMAN;sp|Q15833|STXB2_HUMAN;tr|M0R0M7|M0R0M7_HUMAN;tr|M0R1A1|M0R1A1_HUMAN;tr|M0QZ54|M0QZ54_HUMAN;tr|R4GMY7|R4GMY7_HUMAN;tr|M0R376|M0R376_HUMAN;tr|M0R0D4|M0R0D4_HUMAN;tr|M0R118|M0R118_HUMAN;tr|A0A087WUN8|A0A087WUN8_HUMAN","tr|A0A087WWS7|A0A087WWS7_HUMAN;sp|Q15833|STXB2_HUMAN;tr|M0R0M7|M0R0M7_HUMAN",2528,"A0A087WWS7"]
["17.8115",1,"17.1955",1,{"$nulls":3},"cholesterol homeostasis;chylomicron remodeling;fatty acid biosynthetic process;low-density lipoprotein particle mediated signaling;phospholipid metabolic process;positive regulation of chemokine secretion;positive regulation of cholesterol storage;positive regulation of inflammatory response;positive regulation of macrophage derived foam cell differentiation;positive regulation of sequestering of triglyceride;regulation of lipoprotein lipase activity;response to cold;response to drug;response to glucose;retinoid metabolic process;triglyceride biosynthetic process;triglyceride catabolic process;triglyceride homeostasis;triglyceride metabolic process;very-low-density lipoprotein particle remodeling","apolipoprotein binding;heparin binding;lipoprotein lipase activity;phospholipase activity;receptor binding;triglyceride binding;triglyceride lipase activity","anchored component of membrane;cell surface;chylomicron;extracellular exosome;extracellular matrix;extracellular region;extracellular space;plasma membrane;very-low-density lipoprotein particle","Alzheimer disease;Cholesterol metabolism;Glycerolipid metabolism;PPAR signaling pathway",null,null,7,7,7,"20.6","20.6","20.6","53.162",0,"34.773",296430000,33,"0.00817875",1,"0.307997","0.0263882","sp|P06858|LIPL_HUMAN;tr|E7EW14|E7EW14_HUMAN;tr|E5RJI0|E5RJI0_HUMAN","sp|P06858|LIPL_HUMAN",885,"P06858","LIPL_HUMAN","Lipoprotein lipase","PL","LPL"]
["25.3169","25.8468","25.5377","25.0147",{"$nulls":9},26,26,18,"68.1","68.1",47,"27.175",0,"323.31",6662800000,259,"0.302805",1,"0.305619","0.820947","tr|Q5HYB6|Q5HYB6_HUMAN;tr|A0A087WWU8|A0A087WWU8_HUMAN;tr|Q5VU61|Q5VU61_HUMAN;tr|J3KN67|J3KN67_HUMAN;tr|D6R904|D6R904_HUMAN;sp|P06753|TPM3_HUMAN;tr|K7EP68|K7EP68_HUMAN;tr|D6RFM2|D6RFM2_HUMAN","tr|Q5HYB6|Q5HYB6_HUMAN;tr|A0A087WWU8|A0A087WWU8_HUMAN;tr|Q5VU61|Q5VU61_HUMAN;tr|J3KN67|J3KN67_HUMAN",5292,"Q5HYB6","Q5HYB6_HUMAN",null,null,"DKFZp686J1372"]
["21.543","21.5251","21.5095","20.9476",{"$nulls":3},"mRNA processing;regulation of transcription, DNA-templated;RNA processing;RNA splicing;transcription, DNA-templated","RNA binding","microtubule cytoskeleton;microtubule organizing center;nuclear speck;nucleoplasm;protein complex",{"$nulls":3},18,18,3,"39.8","39.8","7.7","59.379",0,"166.27",2052100000,198,"0.408147",1,"0.305456","1.08667","sp|Q14498|RBM39_HUMAN;tr|H0Y4X3|H0Y4X3_HUMAN","sp|Q14498|RBM39_HUMAN;tr|H0Y4X3|H0Y4X3_HUMAN",2363,"Q14498","RBM39_HUMAN","RNA-binding protein 39",null,"RBM39"]
["18.7263","20.4886","19.0032","19.6051",{"$nulls":3},"dendrite extension;positive regulation of dendritic spine development","basal RNA polymerase II transcription machinery binding;RNA binding","chromosome;nucleolus",{"$nulls":3},2,2,2,"21.7","21.7","21.7","15.225",0,"9.0714",383380000,31,"0.110395",1,"0.303299","0.325745","sp|Q9BRT6|LLPH_HUMAN","sp|Q9BRT6|LLPH_HUMAN",3941,"Q9BRT6","LLPH_HUMAN","Protein LLP homolog",null,"LLPH"]
["21.2786","21.9589","21.6","21.0324",{"$nulls":3},"nucleotide-excision repair, DNA damage recognition;post-translational protein modification;protein deneddylation;transcription-coupled nucleotide-excision repair",null,"COP9 signalosome;cytosol;nucleoplasm",{"$nulls":3},9,9,9,44,44,44,"30.276",0,"36.412",311590000,29,"0.247845",1,"0.302541","0.682941","sp|Q9UBW8|CSN7A_HUMAN;tr|F5H7C6|F5H7C6_HUMAN;tr|F5GYF7|F5GYF7_HUMAN;tr|F5H248|F5H248_HUMAN;tr|F5H4U8|F5H4U8_HUMAN;tr|F5H4Z0|F5H4Z0_HUMAN;tr|F5H3M6|F5H3M6_HUMAN;tr|G3XAP1|G3XAP1_HUMAN;tr|F5GXT7|F5GXT7_HUMAN","sp|Q9UBW8|CSN7A_HUMAN;tr|F5H7C6|F5H7C6_HUMAN;tr|F5GYF7|F5GYF7_HUMAN;tr|F5H248|F5H248_HUMAN",4683,"Q9UBW8","CSN7A_HUMAN","COP9 signalosome complex subunit 7a","GN7a;ignalosome subunit 7a","COPS7A"]
["23.3728","24.1722","23.4913","23.4505",{"$nulls":3},"mRNA splicing, via spliceosome;nuclear import;RNA splicing;spliceosomal complex assembly;spliceosomal snRNP assembly","RNA binding","catalytic step 2 spliceosome;cytosol;extracellular exosome;methylosome;nucleoplasm;pICln-Sm protein complex;precatalytic spliceosome;small nuclear ribonucleoprotein complex;SMN-Sm protein complex;spliceosomal complex;U1 snRNP;U12-type spliceosomal complex;U2 snRNP;U4 snRNP;U4/U6 x U5 tri-snRNP complex;U5 snRNP","Spliceosome",null,null,7,7,7,"61.9","61.9","61.9","13.527",0,"44.981",1948300000,101,"0.275935",1,"0.301594","0.753566","sp|P62316|SMD2_HUMAN;tr|K7ERG4|K7ERG4_HUMAN;tr|K7EJB5|K7EJB5_HUMAN","sp|P62316|SMD2_HUMAN;tr|K7ERG4|K7ERG4_HUMAN",1892,"P62316","SMD2_HUMAN","Small nuclear ribonucleoprotein Sm D2","m-D2","SNRPD2"]
["25.3647","25.8474","25.4929","25.117",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleus;rough endoplasmic reticulum","Ribosome",null,null,24,24,24,"48.7","48.7","48.7","47.697",0,"169.5",6857700000,214,"0.367774",1,"0.301096","0.98422","sp|P36578|RL4_HUMAN;tr|H3BM89|H3BM89_HUMAN;tr|H3BTP7|H3BTP7_HUMAN;tr|H3BU31|H3BU31_HUMAN","sp|P36578|RL4_HUMAN;tr|H3BM89|H3BM89_HUMAN",1409,"P36578","RL4_HUMAN","60S ribosomal protein L4",null,"RPL4"]
["26.3677","27.0077","26.5458","26.2318",{"$nulls":3},"cytoplasmic sequestering of protein;hippo signaling;MAPK cascade;membrane organization;negative regulation of G-protein coupled receptor protein signaling pathway;negative regulation of protein dephosphorylation;negative regulation of transcription, DNA-templated;positive regulation of catalytic activity;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein heterooligomerization;protein targeting;regulation of mRNA stability;viral process","cadherin binding;enzyme binding;histone deacetylase binding;identical protein binding;phosphoprotein binding;phosphoserine residue binding;protein complex binding;protein C-terminus binding;protein domain specific binding;transcription corepressor activity","cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;focal adhesion;melanosome;membrane;mitochondrion;nucleus;perinuclear region of cytoplasm;protein complex;transcriptional repressor complex","Cell cycle;Hepatitis B;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,15,9,9,"64.6","50.4","50.4","28.082",0,"323.31",12386000000,140,"0.309908",1,"0.298952","0.838753","sp|P31946|1433B_HUMAN;tr|Q4VY20|Q4VY20_HUMAN;tr|Q4VY19|Q4VY19_HUMAN;tr|A0A0J9YWE8|A0A0J9YWE8_HUMAN;tr|A0A0J9YWZ2|A0A0J9YWZ2_HUMAN","sp|P31946|1433B_HUMAN",1340,"P31946","1433B_HUMAN","14-3-3 protein beta/alpha",null,"YWHAB"]
["19.5844","19.7381","19.3225","19.4042",{"$nulls":3},"estrogen biosynthetic process;steroid biosynthetic process","17-beta-hydroxysteroid dehydrogenase (NADP+) activity;17-beta-ketosteroid reductase activity;3-keto sterol reductase activity;estradiol 17-beta-dehydrogenase activity;nucleotide binding","extracellular region","Steroid hormone biosynthesis",null,null,5,5,5,"25.4","25.4","25.4","28.308",0,"8.2567",86676000,7,"1.12049",1,"0.297883","3.42303","sp|Q6UWP2|DHR11_HUMAN;tr|A0A087WYV4|A0A087WYV4_HUMAN;tr|A0A087X0R1|A0A087X0R1_HUMAN;tr|A0A087WZN3|A0A087WZN3_HUMAN","sp|Q6UWP2|DHR11_HUMAN",2905,"Q6UWP2","DHR11_HUMAN","Dehydrogenase/reductase SDR family member 11",null,"DHRS11"]
["18.1198","19.9529","18.764","18.7138",{"$nulls":3},"cellular protein metabolic process;fucose metabolic process;glycoside catabolic process;neutrophil degranulation;post-translational protein modification;regulation of entry of bacterium into host cell;response to bacterium","alpha-L-fucosidase activity","azurophil granule lumen;endoplasmic reticulum lumen;extracellular exosome;extracellular region;extracellular space","Other glycan degradation",null,null,8,8,8,"18.4","18.4","18.4","54.066",0,"28.692",160560000,12,"0.109931",1,"0.297504","0.324477","sp|Q9BTY2|FUCO2_HUMAN;tr|Q7Z6V2|Q7Z6V2_HUMAN","sp|Q9BTY2|FUCO2_HUMAN",3975,"Q9BTY2","FUCO2_HUMAN","Plasma alpha-L-fucosidase",null,"FUCA2"]
["18.237","16.8601","18.1386","16.3672",{"$nulls":3},"histone mRNA catabolic process;mRNA polyadenylation;transcription, DNA-templated","ATP binding;identical protein binding;magnesium ion binding;manganese ion binding;polynucleotide adenylyltransferase activity;protein homodimerization activity;RNA binding;UTP binding","intracellular membrane-bounded organelle;mitochondrion",{"$nulls":3},14,14,14,"25.4","25.4","25.4","66.171",0,"81.807",696160000,76,"0.0878957",1,"0.295673","0.263576","sp|Q9NVV4|PAPD1_HUMAN;tr|Q5T851|Q5T851_HUMAN;tr|Q5T852|Q5T852_HUMAN","sp|Q9NVV4|PAPD1_HUMAN",4504,"Q9NVV4","PAPD1_HUMAN","Poly(A) RNA polymerase, mitochondrial","AP","MTPAP"]
["21.0438","21.2938","21.0677","20.6797",{"$nulls":3},"branched-chain amino acid catabolic process;fatty acid metabolic process","acyl-CoA dehydrogenase activity;flavin adenine dinucleotide binding","extracellular exosome;mitochondrial matrix;mitochondrion","Fatty acid degradation;Fatty acid metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,10,10,10,"31.5","31.5","31.5","47.485",0,"41.617",330130000,38,"0.48238",1,"0.295104","1.27871","sp|P45954|ACDSB_HUMAN","sp|P45954|ACDSB_HUMAN",1497,"P45954","ACDSB_HUMAN","Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial","BCAD","ACADSB"]
["25.1489","26.0384","25.342","25.2621",{"$nulls":3},"cell redox homeostasis","isomerase activity","cell",{"$nulls":3},6,1,1,"41.5","11.4","11.4","13.519",0,"60.144",3958300000,30,"0.236001",1,"0.291618","0.653053","tr|H7BZJ3|H7BZJ3_HUMAN","tr|H7BZJ3|H7BZJ3_HUMAN",5267,"H7BZJ3","H7BZJ3_HUMAN",null,null,"PDIA3"]
["20.5623","20.5739","20.263","20.2927",{"$nulls":4},"translation initiation factor activity","cytoplasm",{"$nulls":3},2,2,2,16,16,16,"24.602","0.0027231","3.2704",115000000,0,"2.52535",1,"0.290247","18.2684","tr|C9JEL3|C9JEL3_HUMAN;tr|B9A044|B9A044_HUMAN;tr|B8ZZ50|B8ZZ50_HUMAN;sp|O60573|IF4E2_HUMAN","tr|C9JEL3|C9JEL3_HUMAN;tr|B9A044|B9A044_HUMAN;tr|B8ZZ50|B8ZZ50_HUMAN;sp|O60573|IF4E2_HUMAN",484,"C9JEL3","C9JEL3_HUMAN",null,null,"EIF4E2"]
["18.2759","18.9673","18.8302","17.8337",{"$nulls":3},"intra-Golgi vesicle-mediated transport;spermatogenesis","cadherin binding;transporter activity","cytosol;extrinsic component of Golgi membrane;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;Golgi transport complex;membrane;nucleolus;nucleoplasm;nucleus",{"$nulls":3},20,20,20,"19.1","19.1","19.1","167.35",0,"56.356",316120000,33,"0.167482",1,"0.289639","0.477642","sp|Q08378|GOGA3_HUMAN;tr|A0A087WV43|A0A087WV43_HUMAN","sp|Q08378|GOGA3_HUMAN",2128,"Q08378","GOGA3_HUMAN","Golgin subfamily A member 3",null,"GOLGA3"]
[1,"14.6636",1,"14.0875",{"$nulls":3},"protein catabolic process","zinc ion binding",{"$nulls":4},2,2,2,"2.9","2.9","2.9","124.07","0.0013035","3.7515",12708000,4,"0.00944997",1,"0.288034","0.0304471","tr|A0A087WTJ9|A0A087WTJ9_HUMAN;sp|Q8IWV7|UBR1_HUMAN;tr|H3BS20|H3BS20_HUMAN;tr|H3BNQ6|H3BNQ6_HUMAN","tr|A0A087WTJ9|A0A087WTJ9_HUMAN;sp|Q8IWV7|UBR1_HUMAN;tr|H3BS20|H3BS20_HUMAN;tr|H3BNQ6|H3BNQ6_HUMAN",3134,"A0A087WTJ9","A0A087WTJ9_HUMAN",null,null,"UBR1"]
["24.5845","24.3479","24.4488","23.9099",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;membrane;nucleolus","Ribosome",null,null,6,6,6,"37.1","37.1","37.1","12.254",0,"17.185",726340000,63,"0.364031",1,"0.286873","0.974772","sp|Q9Y3U8|RL36_HUMAN;tr|J3QSB5|J3QSB5_HUMAN;tr|J3KTD3|J3KTD3_HUMAN","sp|Q9Y3U8|RL36_HUMAN;tr|J3QSB5|J3QSB5_HUMAN",4998,"Q9Y3U8","RL36_HUMAN","60S ribosomal protein L36",null,"RPL36"]
[1,"16.5311",1,"15.9576",{"$nulls":9},8,8,8,"14.3","14.3","14.3","77.147",0,"20.209",120550000,30,"0.00824437",1,"0.28676","0.026598","tr|A0A087WW95|A0A087WW95_HUMAN;sp|O15119|TBX3_HUMAN;sp|Q13207|TBX2_HUMAN","tr|A0A087WW95|A0A087WW95_HUMAN;sp|O15119|TBX3_HUMAN",326,"A0A087WW95"]
["18.6944","18.1671","19.0315","17.2607",{"$nulls":3},"cellular response to DNA damage stimulus;defense response to virus;double-strand break repair;endosome to lysosome transport;histone H2A ubiquitination;histone H2B ubiquitination;histone monoubiquitination;innate immune response;negative regulation of ubiquitin-protein transferase activity;positive regulation of chromatin binding;positive regulation of defense response to virus by host;positive regulation of double-strand break repair via nonhomologous end joining;positive regulation of NAD+ ADP-ribosyltransferase activity;positive regulation of protein binding;positive regulation of protein localization to early endosome;positive regulation of protein localization to nucleus;positive regulation of receptor catabolic process;positive regulation of transcription, DNA-templated;protein autoubiquitination;protein K48-linked ubiquitination;protein polyubiquitination;protein transport;protein ubiquitination involved in ubiquitin-dependent protein catabolic process","enzyme activator activity;enzyme binding;enzyme inhibitor activity;histone binding;metal ion binding;RNA binding;STAT family protein binding;ubiquitin-like protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;cytosol;early endosome membrane;lysosomal membrane;lysosome;nucleoplasm;nucleus;protein complex","Notch signaling pathway",null,null,11,11,11,"16.8","16.8","16.8","83.553",0,"52.251",390670000,32,"0.10396",1,"0.284649","0.308122","sp|Q8TDB6|DTX3L_HUMAN","sp|Q8TDB6|DTX3L_HUMAN",3384,"Q8TDB6","DTX3L_HUMAN","E3 ubiquitin-protein ligase DTX3L",null,"DTX3L"]
["23.88","24.3385","24.0291","23.6252",{"$nulls":3},"carbohydrate metabolic process;neutrophil degranulation;protein folding","carbohydrate binding;enzyme binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;plasma membrane;specific granule membrane",{"$nulls":3},15,15,15,"48.6","48.6","48.6","32.233",0,"201.57",2321200000,113,"0.343599",1,"0.282088","0.923315","sp|Q14165|MLEC_HUMAN;tr|F5H1S8|F5H1S8_HUMAN;tr|H0YG07|H0YG07_HUMAN;tr|F5GX14|F5GX14_HUMAN","sp|Q14165|MLEC_HUMAN;tr|F5H1S8|F5H1S8_HUMAN",2340,"Q14165","MLEC_HUMAN","Malectin",null,"MLEC"]
["23.3027","23.4686","23.6086","22.6018",{"$nulls":3},"aromatic compound catabolic process;epoxide metabolic process;response to organic cyclic compound;response to toxic substance;xenobiotic metabolic process","cis-stilbene-oxide hydrolase activity;epoxide hydrolase activity","endoplasmic reticulum membrane;integral component of membrane;organelle membrane","Bile secretion;Chemical carcinogenesis;Metabolism of xenobiotics by cytochrome P450",null,null,17,17,17,"38.7","38.7","38.7","52.948",0,"115.82",2130400000,85,"0.195372",1,"0.280452","0.549687","sp|P07099|HYEP_HUMAN;tr|B1AQP9|B1AQP9_HUMAN;tr|B1AQP8|B1AQP8_HUMAN","sp|P07099|HYEP_HUMAN",888,"P07099","HYEP_HUMAN","Epoxide hydrolase 1",null,"EPHX1"]
["19.6323","19.5661","19.5063","19.1344",{"$nulls":3},"establishment of integrated proviral latency;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;negative regulation of viral genome replication;nuclear transport;response to virus","DNA binding;enzyme binding;identical protein binding;LEM domain binding;protein C-terminus binding;protein homodimerization activity;protein N-terminus binding","chromosome;cytoplasm;cytosol;extracellular exosome;nuclear envelope;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"29.2","29.2","29.2","10.058",0,"19.797",230680000,20,"0.556208",1,"0.278872","1.47644","sp|O75531|BAF_HUMAN","sp|O75531|BAF_HUMAN",583,"O75531","BAF_HUMAN","Barrier-to-autointegration factor",null,"BANF1"]
["23.7744","23.5492","23.8541","22.915",{"$nulls":3},"fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;regulation of RNA splicing;RNA metabolic process;RNA processing","poly(U) RNA binding;RNA binding","catalytic step 2 spliceosome;cytosol;membrane;nucleoplasm;nucleus",{"$nulls":3},13,11,8,"48.6","42.5","32.3","49.229",0,"133.55",2142100000,119,"0.204944",1,"0.277273","0.574181","sp|P31943|HNRH1_HUMAN;tr|G8JLB6|G8JLB6_HUMAN;tr|E9PCY7|E9PCY7_HUMAN;tr|D6RIU0|D6RIU0_HUMAN;tr|D6RBM0|D6RBM0_HUMAN;tr|H0YB39|H0YB39_HUMAN;tr|D6RFM3|D6RFM3_HUMAN;tr|E7EQJ0|E7EQJ0_HUMAN;tr|D6RAM1|D6RAM1_HUMAN;tr|E5RGV0|E5RGV0_HUMAN;tr|D6R9T0|D6R9T0_HUMAN;tr|D6RIT2|D6RIT2_HUMAN;tr|D6RDU3|D6RDU3_HUMAN;tr|D6RJ04|D6RJ04_HUMAN;tr|D6RIH9|D6RIH9_HUMAN;tr|H0YBD7|H0YBD7_HUMAN;tr|E5RGH4|E5RGH4_HUMAN;tr|E7EN40|E7EN40_HUMAN;tr|H0YBG7|H0YBG7_HUMAN;tr|D6RDL0|D6RDL0_HUMAN;tr|D6RF17|D6RF17_HUMAN;tr|H0YAQ2|H0YAQ2_HUMAN;tr|D6R9D3|D6R9D3_HUMAN","sp|P31943|HNRH1_HUMAN;tr|G8JLB6|G8JLB6_HUMAN;tr|E9PCY7|E9PCY7_HUMAN;tr|D6RIU0|D6RIU0_HUMAN;tr|D6RBM0|D6RBM0_HUMAN;tr|H0YB39|H0YB39_HUMAN",1339,"P31943","HNRH1_HUMAN","Heterogeneous nuclear ribonucleoprotein H","nRNP H","HNRNPH1"]
["19.9197","21.3832","19.8023","20.9477",{"$nulls":3},"activation of protein kinase A activity;blood coagulation;calcium-mediated signaling using intracellular calcium source;cell communication by electrical coupling involved in cardiac conduction;cellular response to epinephrine stimulus;cellular response to glucagon stimulus;cellular response to glucose stimulus;cellular response to heat;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;high-density lipoprotein particle assembly;mRNA processing;peptidyl-serine phosphorylation;positive regulation of cell cycle arrest;protein phosphorylation;regulation of bicellular tight junction assembly;regulation of cardiac conduction;regulation of cardiac muscle contraction;regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;regulation of cytosolic calcium ion concentration;regulation of G2/M transition of mitotic cell cycle;regulation of heart rate;regulation of macroautophagy;regulation of osteoblast differentiation;regulation of proteasomal protein catabolic process;regulation of protein binding;regulation of ryanodine-sensitive calcium-release channel activity;renal water homeostasis;sperm capacitation;stimulatory C-type lectin receptor signaling pathway","ATP binding;cAMP-dependent protein kinase activity;protein kinase A regulatory subunit binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;ubiquitin protein ligase binding","acrosomal vesicle;calcium channel complex;cAMP-dependent protein kinase complex;centrosome;ciliary base;cytoplasm;cytosol;extracellular exosome;intercellular bridge;mitochondrion;motile cilium;nuclear speck;nucleoplasm;nucleotide-activated protein kinase complex;nucleus;perinuclear region of cytoplasm;plasma membrane raft;sperm midpiece","Adrenergic signaling in cardiomyocytes;Alcoholism;Aldosterone synthesis and secretion;Amoebiasis;Amphetamine addiction;Apelin signaling pathway;Autophagy - animal;Bile secretion;Calcium signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Cocaine addiction;Cortisol synthesis and secretion;Cushing syndrome;Dilated cardiomyopathy (DCM);Dopaminergic synapse;Endocrine and other factor-regulated calcium reabsorption;Endocrine resistance;Estrogen signaling pathway;GABAergic synapse;Gap junction;Gastric acid secretion;Glucagon signaling pathway;Glutamatergic synapse;GnRH signaling pathway;Hedgehog signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Inflammatory mediator regulation of TRP channels;Insulin secretion;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Morphine addiction;Olfactory transduction;Oocyte meiosis;Ovarian steroidogenesis;Oxytocin signaling pathway;Parathyroid hormone synthesis, secretion and action;Parkinson disease;Pathways in cancer;Platelet activation;Prion diseases;Progesterone-mediated oocyte maturation;Proteoglycans in cancer;Ras signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Retrograde endocannabinoid signaling;Salivary secretion;Serotonergic synapse;Taste transduction;Thermogenesis;Thyroid hormone signaling pathway;Thyroid hormone synthesis;Tight junction;Vascular smooth muscle contraction;Vasopressin-regulated water reabsorption;Vibrio cholerae infection;Viral carcinogenesis;Wnt signaling pathway",null,null,6,6,6,"21.7","21.7","21.7","40.589","0.00025221","6.5404",374330000,5,"0.100096",1,"0.276429","0.297483","sp|P17612|KAPCA_HUMAN;tr|Q15136|Q15136_HUMAN;tr|K7ERP6|K7ERP6_HUMAN;tr|A0A087WVC4|A0A087WVC4_HUMAN;sp|P22694|KAPCB_HUMAN;tr|A0A0A0MS54|A0A0A0MS54_HUMAN;tr|B1APF7|B1APF7_HUMAN;tr|B1APG1|B1APG1_HUMAN;tr|B1APG0|B1APG0_HUMAN;tr|B1APG2|B1APG2_HUMAN;tr|B1APF8|B1APF8_HUMAN;tr|B1APF9|B1APF9_HUMAN;tr|B1APG3|B1APG3_HUMAN;sp|P22612|KAPCG_HUMAN","sp|P17612|KAPCA_HUMAN;tr|Q15136|Q15136_HUMAN;tr|K7ERP6|K7ERP6_HUMAN;tr|A0A087WVC4|A0A087WVC4_HUMAN;sp|P22694|KAPCB_HUMAN;tr|A0A0A0MS54|A0A0A0MS54_HUMAN",1102,"P17612","KAPCA_HUMAN","cAMP-dependent protein kinase catalytic subunit alpha","KA C-alpha","PRKACA"]
["18.3751","18.0572","18.4825","17.4009",{"$nulls":9},3,3,3,"15.5","15.5","15.5","37.909","0.0048465","2.7685",48885000,4,"0.171017",1,"0.274418","0.486836","tr|A0A087WZP8|A0A087WZP8_HUMAN;sp|P49662|CASP4_HUMAN;tr|H0YD34|H0YD34_HUMAN","tr|A0A087WZP8|A0A087WZP8_HUMAN;sp|P49662|CASP4_HUMAN",1587,"A0A087WZP8"]
["24.7732","25.12","24.8639","24.4817",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;barbed-end actin filament capping;blood coagulation;ER to Golgi vesicle-mediated transport;innate immune response;movement of cell or subcellular component;protein complex assembly","actin binding","actin cytoskeleton;brush border;cortical cytoskeleton;cytosol;extracellular exosome;extracellular region;F-actin capping protein complex;membrane","Endocytosis",null,null,10,10,9,"56.6","56.6","53.1","32.949",0,"308.7",3170300000,107,"0.398125",1,"0.2738","1.06113","sp|P47755|CAZA2_HUMAN;tr|C9JUG7|C9JUG7_HUMAN;tr|F8W9N7|F8W9N7_HUMAN;tr|A0A0D9SET8|A0A0D9SET8_HUMAN;tr|F8WED3|F8WED3_HUMAN","sp|P47755|CAZA2_HUMAN;tr|C9JUG7|C9JUG7_HUMAN;tr|F8W9N7|F8W9N7_HUMAN;tr|A0A0D9SET8|A0A0D9SET8_HUMAN",1528,"P47755","CAZA2_HUMAN","F-actin-capping protein subunit alpha-2",null,"CAPZA2"]
["15.9219","16.6978","15.5672","16.5087",{"$nulls":3},"multicellular organism development;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;regulation of transcription, DNA-templated;signal transduction;transcription, DNA-templated","DNA binding transcription factor activity;metal ion binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcription regulatory region DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","histone deacetylase complex;nucleoplasm",{"$nulls":3},4,4,4,"6.3","6.3","6.3","115.27",0,"18.703",42634000,8,"0.155305",1,"0.271943","0.445808","sp|O75362|ZN217_HUMAN;tr|Q9BZ31|Q9BZ31_HUMAN","sp|O75362|ZN217_HUMAN",551,"O75362","ZN217_HUMAN","Zinc finger protein 217",null,"ZNF217"]
["19.6917","19.7268","19.4418","19.4351",{"$nulls":3},"actin polymerization or depolymerization;cell division;cellular protein complex localization;dendritic spine morphogenesis;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component;negative regulation of lymphocyte migration;negative regulation of membrane tubulation;positive regulation of Arp2/3 complex-mediated actin nucleation;positive regulation of clathrin-dependent endocytosis;positive regulation of filopodium assembly;protein complex assembly;regulation of nitric-oxide synthase activity;regulation of protein localization;regulation of transcription, DNA-templated;response to bacterium;spindle localization;transcription, DNA-templated;vesicle budding from membrane;vesicle organization;vesicle transport along actin filament","actin binding;GTPase regulator activity","actin cap;actin cytoskeleton;cytoplasmic vesicle;cytosol;endocytic vesicle membrane;extracellular exosome;lamellipodium;nucleus;plasma membrane","Adherens junction;Bacterial invasion of epithelial cells;Chemokine signaling pathway;Choline metabolism in cancer;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis;Tight junction;Yersinia infection",null,null,8,8,8,22,22,22,"54.826",0,"22.061",124640000,19,"2.36364",1,"0.270742","15.1497","sp|O00401|WASL_HUMAN","sp|O00401|WASL_HUMAN",219,"O00401","WASL_HUMAN","Neural Wiskott-Aldrich syndrome protein",{"$f":"-WASP","v":{"$error":"#NAME?"}},"WASL"]
[1,"16.6121",1,"16.0718",{"$nulls":3},"mitochondrial fission;peroxisome fission","GTP binding;GTPase activity","cytosol;intracellular membrane-bounded organelle",{"$nulls":3},23,1,1,"47.9","2.9","2.9","79.621","0.0048731","2.8408",15337000,4,"0.00771323",1,"0.270157","0.0248991","tr|G8JLD5|G8JLD5_HUMAN","tr|G8JLD5|G8JLD5_HUMAN",5244,"G8JLD5","G8JLD5_HUMAN",null,null,"DNM1L"]
["18.619","18.7378","19.1059","17.7174",{"$nulls":4},"ATP binding","cytosol;nucleoplasm",{"$nulls":3},9,9,9,"13.2","13.2","13.2","107.43",0,"45.295",287740000,52,"0.1315",1,"0.2667","0.382749","tr|E7EXA6|E7EXA6_HUMAN;sp|Q8WVB6|CTF18_HUMAN;tr|A0A0D9SF58|A0A0D9SF58_HUMAN;tr|F8WCC1|F8WCC1_HUMAN","tr|E7EXA6|E7EXA6_HUMAN;sp|Q8WVB6|CTF18_HUMAN;tr|A0A0D9SF58|A0A0D9SF58_HUMAN",3435,"E7EXA6","E7EXA6_HUMAN",null,null,"CHTF18"]
["23.8658","23.613","24.0436","22.9029",{"$nulls":3},"cellular response to interferon-beta;free ubiquitin chain polymerization;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;positive regulation of peptidyl-threonine phosphorylation;positive regulation of type I interferon-mediated signaling pathway;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K48-linked ubiquitination;protein ubiquitination;regulation of proteasomal ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process","ATP binding;ubiquitin protein ligase binding;ubiquitin-protein transferase activity;ubiquitin-ubiquitin ligase activity","cytoplasm;cytosol;extracellular exosome;filopodium tip;nucleus","Ubiquitin mediated proteolysis",null,null,10,10,10,"62.5","62.5","62.5","22.406",0,"198.63",1346800000,75,"0.159042",1,"0.266159","0.455606","sp|P61086|UBE2K_HUMAN;tr|D6RDM7|D6RDM7_HUMAN;tr|D6RFX1|D6RFX1_HUMAN","sp|P61086|UBE2K_HUMAN;tr|D6RDM7|D6RDM7_HUMAN",1829,"P61086","UBE2K_HUMAN","Ubiquitin-conjugating enzyme E2 K",null,"UBE2K"]
["21.2025","22.8806","21.5424","22.0102",{"$nulls":3},"apoptotic process;negative regulation of anoikis;negative regulation of gene expression;positive regulation of anoikis","aminoacyl-tRNA hydrolase activity","cytosol;membrane;mitochondrion",{"$nulls":3},5,5,5,"47.5","47.5","47.5","19.193",0,"69.965",1774300000,89,"0.102642",1,"0.265241","0.3045","sp|Q9Y3E5|PTH2_HUMAN;tr|J3KQ48|J3KQ48_HUMAN","sp|Q9Y3E5|PTH2_HUMAN;tr|J3KQ48|J3KQ48_HUMAN",4988,"Q9Y3E5","PTH2_HUMAN","Peptidyl-tRNA hydrolase 2, mitochondrial","TH 2","PTRH2"]
["20.5131","20.5782","20.7469","19.8149",{"$nulls":3},"actin filament bundle retrograde transport;axonogenesis;Cdc42 protein signal transduction;cytoplasmic actin-based contraction involved in cell motility;endoplasmic reticulum polarization;netrin-activated signaling pathway;neuron projection morphogenesis;positive regulation of axon extension;positive regulation of neuron migration;Ras protein signal transduction;regulation of establishment of cell polarity;substrate-dependent cell migration, cell extension","actin filament binding;cadherin binding;kinesin binding","axon;axonal growth cone;cell leading edge;cytoplasm;filopodium;growth cone;lamellipodium;microtubule;microtubule associated complex;microtubule cytoskeleton;perikaryon;perinuclear region of cytoplasm",{"$nulls":3},16,16,16,"29.8","29.8","29.8","71.639",0,"45.318",463270000,53,"0.202018",1,"0.264726","0.566704","sp|A0MZ66|SHOT1_HUMAN","sp|A0MZ66|SHOT1_HUMAN",152,"A0MZ66","SHOT1_HUMAN","Shootin-1 {ECO:0000312|HGNC:HGNC:29319}",null,"SHTN1"]
["20.1206","19.654","20.3623","18.885",{"$nulls":3},"blood coagulation;regulation of protein kinase A signaling","protein kinase A regulatory subunit binding;RNA binding","cytosol;integral component of membrane;membrane;mitochondrial outer membrane;mitochondrion",{"$nulls":3},13,13,13,23,23,23,"97.34",0,"120.07",301590000,40,"0.115766",1,"0.263642","0.340362","sp|Q92667|AKAP1_HUMAN;tr|I3L0W0|I3L0W0_HUMAN;tr|I3L2A2|I3L2A2_HUMAN;tr|I3L2N7|I3L2N7_HUMAN;tr|I3L0K6|I3L0K6_HUMAN;tr|I3L3K1|I3L3K1_HUMAN;tr|I3L364|I3L364_HUMAN;tr|I3NI36|I3NI36_HUMAN","sp|Q92667|AKAP1_HUMAN",3515,"Q92667","AKAP1_HUMAN","A-kinase anchor protein 1, mitochondrial",null,"AKAP1"]
["19.747","20.6373","20.1908","19.6685",{"$nulls":3},"cell division;Golgi disassembly;histone H3-S10 phosphorylation;histone H3-T3 phosphorylation;mitotic nuclear envelope disassembly;mitotic nuclear envelope reassembly;protein autophosphorylation;protein phosphorylation;regulation of cell shape","ATP binding;histone kinase activity (H3-S10 specific);histone kinase activity (H3-T3 specific);nucleosomal histone binding;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity","cytosol;Golgi stack;nucleolus;nucleoplasm;nucleus;spindle",{"$nulls":3},8,8,8,"24.7","24.7","24.7","45.476",0,"38.686",338030000,47,"0.179469",1,"0.262547","0.508742","sp|Q99986|VRK1_HUMAN;tr|H0YJ50|H0YJ50_HUMAN;tr|H0YJJ9|H0YJJ9_HUMAN;tr|H0YJF7|H0YJF7_HUMAN","sp|Q99986|VRK1_HUMAN;tr|H0YJ50|H0YJ50_HUMAN",3898,"Q99986","VRK1_HUMAN","Serine/threonine-protein kinase VRK1",null,"VRK1"]
["22.8347","23.5151","23.1209","22.7052",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;mitochondrial respiratory chain complex III assembly;oxidation-reduction process;oxidative phosphorylation",null,"mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrial respiratory chain complex III","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,5,5,5,"44.1","44.1","44.1","13.53",0,"26.132",431120000,32,"0.23751",1,"0.261863","0.656865","sp|P14927|QCR7_HUMAN;tr|B7Z2R2|B7Z2R2_HUMAN;tr|E5RHG9|E5RHG9_HUMAN","sp|P14927|QCR7_HUMAN;tr|B7Z2R2|B7Z2R2_HUMAN",1055,"P14927","QCR7_HUMAN","Cytochrome b-c1 complex subunit 7",null,"UQCRB"]
["18.1634","19.3506","18.3344","18.6602",{"$nulls":3},"nuclear export",null,"nucleus",{"$nulls":3},25,25,25,"27.3","27.3","27.3","122.95",0,"151.97",2318900000,211,"0.146231",1,"0.259694","0.42191","sp|O60524|NEMF_HUMAN;tr|G3V5V3|G3V5V3_HUMAN;tr|G3V4D9|G3V4D9_HUMAN;tr|G3V547|G3V547_HUMAN","sp|O60524|NEMF_HUMAN;tr|G3V5V3|G3V5V3_HUMAN",479,"O60524","NEMF_HUMAN","Nuclear export mediator factor NEMF",null,"NEMF"]
["22.7027","23.3425","23.0612","22.4686",{"$nulls":3},"angiogenesis;apoptotic process;IRE1-mediated unfolded protein response;negative regulation of apoptotic process;positive regulation of angiogenesis;positive regulation of endothelial cell proliferation;positive regulation of MAPK cascade;positive regulation of phosphatidylinositol 3-kinase signaling;positive regulation of protein kinase B signaling;positive regulation of protein phosphorylation;positive regulation of transcription from RNA polymerase II promoter",null,"endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular space",{"$nulls":3},4,4,4,"23.1","23.1","23.1","18.795",0,"10.081",443920000,23,"0.211503",1,"0.257667","0.59091","sp|Q969H8|MYDGF_HUMAN;tr|M0QXF7|M0QXF7_HUMAN;tr|M0QYN0|M0QYN0_HUMAN","sp|Q969H8|MYDGF_HUMAN;tr|M0QXF7|M0QXF7_HUMAN;tr|M0QYN0|M0QYN0_HUMAN",3577,"Q969H8","MYDGF_HUMAN","Myeloid-derived growth factor {ECO:0000303|PubMed:25581518, ECO:0000312|HGNC:HGNC:16948}","YDGF {ECO:0000303|PubMed:25581518}","MYDGF"]
["22.1356","22.0817","22.4016","21.3011",{"$nulls":3},"phenylalanyl-tRNA aminoacylation;protein heterotetramerization;translation;tRNA aminoacylation for protein translation","ATP binding;magnesium ion binding;phenylalanine-tRNA ligase activity;RNA binding","cytoplasm;cytosol;membrane;phenylalanine-tRNA ligase complex","Aminoacyl-tRNA biosynthesis",null,null,21,21,21,"40.6","40.6","40.6","66.115",0,"69.559",1241700000,92,"0.16344",1,"0.257337","0.467103","sp|Q9NSD9|SYFB_HUMAN","sp|Q9NSD9|SYFB_HUMAN",4441,"Q9NSD9","SYFB_HUMAN","Phenylalanine--tRNA ligase beta subunit",null,"FARSB"]
["22.5285","22.5995","22.646","21.9695",{"$nulls":3},"cell redox homeostasis;glycoprotein metabolic process;neutrophil degranulation;protein folding;response to endoplasmic reticulum stress;response to unfolded protein","protein disulfide isomerase activity","cell surface;endoplasmic reticulum lumen;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;extracellular region;specific granule lumen",{"$nulls":3},13,13,13,"37.7","37.7","37.7","46.971",0,"123.44",960020000,51,"0.275818",1,"0.256214","0.753273","sp|Q9BS26|ERP44_HUMAN","sp|Q9BS26|ERP44_HUMAN",3945,"Q9BS26","ERP44_HUMAN","Endoplasmic reticulum resident protein 44","R protein 44;Rp44","ERP44"]
["20.3217","20.6055","20.1309","20.2844",{"$nulls":9},4,4,4,"23.6","23.6","23.6","23.889",0,"10.498",148380000,10,"0.595871",1,"0.255894","1.58619","sp|Q6P1X6|CH082_HUMAN;tr|H0YF29|H0YF29_HUMAN","sp|Q6P1X6|CH082_HUMAN;tr|H0YF29|H0YF29_HUMAN",2860,"Q6P1X6","CH082_HUMAN","UPF0598 protein C8orf82",null,"C8orf82"]
["19.743","20.5479","20.1515","19.6293",{"$nulls":3},"ATP-dependent chromatin remodeling;beta-catenin-TCF complex assembly;chromatin organization;chromatin remodeling;covalent chromatin modification;interleukin-7-mediated signaling pathway;negative regulation of androgen receptor signaling pathway;negative regulation of cell growth;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle;negative regulation of transcription, DNA-templated;nervous system development;neural retina development;nucleosome disassembly;positive regulation by host of viral transcription;positive regulation of DNA binding transcription factor activity;positive regulation of glucose mediated signaling pathway;positive regulation of pri-miRNA transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;positive regulation of transcription, DNA-templated;positive regulation of Wnt signaling pathway;regulation of transcription from RNA polymerase II promoter","androgen receptor binding;ATP binding;DNA polymerase binding;DNA-dependent ATPase activity;helicase activity;lysine-acetylated histone binding;p53 binding;protein N-terminus binding;RNA polymerase I CORE element sequence-specific DNA binding;RNA polymerase II transcription coactivator activity;Tat protein binding;transcription coactivator activity;transcription corepressor activity;transcription factor binding","extracellular space;membrane;nBAF complex;npBAF complex;nuclear chromatin;nucleolus;nucleoplasm;nucleus;protein complex;SWI/SNF complex","Hepatocellular carcinoma;Thermogenesis",null,null,58,58,0,"37.3","37.3",0,"184.64",0,"323.31",7769100000,661,"0.188361",1,"0.255057","0.531676","sp|P51532|SMCA4_HUMAN;tr|Q9HBD4|Q9HBD4_HUMAN","sp|P51532|SMCA4_HUMAN;tr|Q9HBD4|Q9HBD4_HUMAN",1653,"P51532","SMCA4_HUMAN","Transcription activator BRG1",null,"SMARCA4"]
["20.3486","20.7397","20.1509","20.4316",{"$nulls":3},"animal organ morphogenesis;cell cycle arrest;cell proliferation;cellular iron ion homeostasis;Fc-epsilon receptor signaling pathway;G1/S transition of mitotic cell cycle;G2/M transition of mitotic cell cycle;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;negative regulation of G2/M transition of mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein monoubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;SCF complex assembly;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;viral process;Wnt signaling pathway","ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cullin-RING ubiquitin ligase complex;cytosol;nucleoplasm;Parkin-FBXW7-Cul1 ubiquitin ligase complex;SCF ubiquitin ligase complex","Cell cycle;Circadian rhythm;Hedgehog signaling pathway;Human immunodeficiency virus 1 infection;Oocyte meiosis;Pathways in cancer;Protein processing in endoplasmic reticulum;TGF-beta signaling pathway;Ubiquitin mediated proteolysis;Wnt signaling pathway",null,null,14,14,14,"22.9","22.9","22.9","89.677",0,"46.904",602530000,50,"0.394113",1,"0.252955","1.05093","sp|Q13616|CUL1_HUMAN;tr|A0A0C4DGX4|A0A0C4DGX4_HUMAN","sp|Q13616|CUL1_HUMAN;tr|A0A0C4DGX4|A0A0C4DGX4_HUMAN",2291,"Q13616","CUL1_HUMAN","Cullin-1","UL-1","CUL1"]
["17.8758","16.3313","18.2196","15.4842",{"$nulls":3},"branching morphogenesis of an epithelial tube;cell cycle phase transition;cell division;cellular response to bleomycin;cellular response to cisplatin;cellular response to DNA damage stimulus;cellular response to hydroxyurea;circadian rhythm;detection of abiotic stimulus;DNA replication;lung development;morphogenesis of an epithelium;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of double-strand break repair;regulation of circadian rhythm;response to abiotic stimulus;transcription, DNA-templated","protein heterodimerization activity;protein homodimerization activity","nuclear chromatin;nucleoplasm;nucleus",{"$nulls":3},13,13,13,"12.8","12.8","12.8","138.66",0,"46.464",352330000,43,"0.0518594",1,"0.251619","0.160197","sp|Q9UNS1|TIM_HUMAN","sp|Q9UNS1|TIM_HUMAN",4853,"Q9UNS1","TIM_HUMAN","Protein timeless homolog","TIM","TIMELESS"]
["19.1993","19.48","19.1624","19.0142",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell differentiation;cell division;microtubule cytoskeleton organization;microtubule depolymerization;microtubule-based movement;mitotic spindle assembly;mitotic spindle organization;nervous system development;regulation of cell migration;retrograde vesicle-mediated transport, Golgi to ER;sister chromatid cohesion","ATP binding;ATPase activity;microtubule binding;microtubule motor activity;motor activity","centriolar subdistal appendage;centriole;centrosome;cytoplasm;cytosol;kinesin complex;membrane;microtubule;nuclear body;nucleolus;nucleus;sperm principal piece;spindle pole",{"$nulls":3},16,16,15,"23.9","23.9","22.7","79.954",0,"61.576",533040000,56,"0.595104",1,"0.251394","1.58404","sp|O00139|KIF2A_HUMAN;tr|D6R9M0|D6R9M0_HUMAN;tr|H0Y8H2|H0Y8H2_HUMAN","sp|O00139|KIF2A_HUMAN",188,"O00139","KIF2A_HUMAN","Kinesin-like protein KIF2A",null,"KIF2A"]
["16.4985","17.0792","16.0902","16.9864",{"$nulls":3},"cysteine biosynthetic process;cysteine biosynthetic process from serine;cysteine biosynthetic process via cystathionine;DNA protection;homocysteine catabolic process;homocysteine metabolic process;hydrogen sulfide biosynthetic process;L-cysteine catabolic process;L-serine catabolic process;L-serine metabolic process;transsulfuration","carbon monoxide binding;cystathionine beta-synthase activity;enzyme binding;heme binding;identical protein binding;metal ion binding;modified amino acid binding;nitric oxide binding;nitrite reductase (NO-forming) activity;oxygen binding;protein homodimerization activity;pyridoxal phosphate binding;S-adenosyl-L-methionine binding;ubiquitin protein ligase binding","cytoplasm;cytosol;nucleus","Biosynthesis of amino acids;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways",null,null,3,3,3,"7.4","7.4","7.4","60.586","0.0013029","3.7502",38727000,2,"0.164259",1,"0.250551","0.46924","sp|P35520|CBS_HUMAN;tr|C9JMA6|C9JMA6_HUMAN","sp|P35520|CBS_HUMAN",1386,"P35520","CBS_HUMAN","Cystathionine beta-synthase {ECO:0000305}",null,"CBS"]
["17.4366","17.0541","16.9952","16.9956",{"$nulls":3},"chromatin organization;DNA methylation;embryo development;histone methylation;negative regulation of G0 to G1 transition;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;peptidyl-lysine dimethylation;peptidyl-lysine monomethylation;regulation of signal transduction by p53 class mediator;response to fungicide","C2H2 zinc finger domain binding;histone methyltransferase activity (H3-K27 specific);histone methyltransferase activity (H3-K9 specific);histone-lysine N-methyltransferase activity;methyltransferase activity;p53 binding;protein-lysine N-methyltransferase activity;zinc ion binding","chromosome;nuclear body;nucleoplasm;nucleus","Longevity regulating pathway;Lysine degradation",null,null,6,6,6,"7.9","7.9","7.9","141.46",0,"10.391",186880000,32,"0.493085",1,"0.249928","1.30692","sp|Q9H9B1|EHMT1_HUMAN;tr|A0A0C4DGF8|A0A0C4DGF8_HUMAN;tr|A0A0D9SFS4|A0A0D9SFS4_HUMAN;tr|A0A0D9SER3|A0A0D9SER3_HUMAN;tr|A0A0D9SFG7|A0A0D9SFG7_HUMAN;tr|A0A0D9SFX4|A0A0D9SFX4_HUMAN;tr|A0A0D9SEQ1|A0A0D9SEQ1_HUMAN;tr|A0A0D9SEP2|A0A0D9SEP2_HUMAN","sp|Q9H9B1|EHMT1_HUMAN;tr|A0A0C4DGF8|A0A0C4DGF8_HUMAN",4273,"Q9H9B1","EHMT1_HUMAN","Histone-lysine N-methyltransferase EHMT1",null,"EHMT1"]
["14.9234","17.706","15.4678","16.6634",{"$nulls":3},"cell division;mitotic cell cycle checkpoint;protein complex assembly;regulation of exit from mitosis;sister chromatid cohesion",null,"actin cytoskeleton;condensed chromosome kinetochore;cytosol;kinetochore microtubule;nucleus;plasma membrane;RZZ complex;spindle pole",{"$nulls":3},5,5,5,"2.9","2.9","2.9","250.75",0,"9.6989",58800000,5,"0.053316",1,"0.249073","0.164483","sp|P50748|KNTC1_HUMAN;tr|E7ES84|E7ES84_HUMAN","sp|P50748|KNTC1_HUMAN;tr|E7ES84|E7ES84_HUMAN",1634,"P50748","KNTC1_HUMAN","Kinetochore-associated protein 1",null,"KNTC1"]
["22.1125","21.0284","22.4642","20.1794",{"$nulls":9},5,5,5,"42.4","42.4","42.4","20.987",0,"31.445",192290000,22,"0.0643614",1,"0.248679","0.196667","tr|E9PPQ1|E9PPQ1_HUMAN;sp|Q16890|TPD53_HUMAN;tr|J3KNE7|J3KNE7_HUMAN;tr|E9PNK6|E9PNK6_HUMAN;tr|E9PNQ9|E9PNQ9_HUMAN","tr|E9PPQ1|E9PPQ1_HUMAN;sp|Q16890|TPD53_HUMAN;tr|J3KNE7|J3KNE7_HUMAN;tr|E9PNK6|E9PNK6_HUMAN;tr|E9PNQ9|E9PNQ9_HUMAN",2581,"E9PPQ1","E9PPQ1_HUMAN",null,null,"TPD52L1"]
["20.9568","21.1207","20.8623","20.7183",{"$nulls":3},"cell differentiation;cellular response to fibroblast growth factor stimulus;cellular response to interleukin-2;cellular response to nerve growth factor stimulus;cellular response to prolactin;cellular response to wortmannin;DNA repair;mitotic cell cycle;mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter;signal transduction involved in DNA damage checkpoint","DNA binding;leucine zipper domain binding;protein kinase binding;protein phosphatase 1 binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;transcription corepressor binding;transcription factor activity, RNA polymerase II transcription factor recruiting;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;WD40-repeat domain binding","catalytic step 2 spliceosome;cytoplasm;membrane;nuclear speck;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein-DNA complex;Prp19 complex","Spliceosome",null,null,36,36,36,"57.1","57.1","57.1","92.25",0,"323.31",5194300000,385,"0.8228",1,"0.248438","2.27823","sp|Q99459|CDC5L_HUMAN","sp|Q99459|CDC5L_HUMAN",3845,"Q99459","CDC5L_HUMAN","Cell division cycle 5-like protein","dc5-like protein","CDC5L"]
["18.1417","18.9349","18.4955","18.0851",{"$nulls":3},"carbohydrate metabolic process;regulation of immune system process","sialate O-acetylesterase activity","extracellular exosome;extracellular space;lysosome",{"$nulls":3},8,8,8,25,25,25,"58.314",0,"16.123",80144000,13,"0.197535",1,"0.247937","0.55523","sp|Q9HAT2|SIAE_HUMAN","sp|Q9HAT2|SIAE_HUMAN",4293,"Q9HAT2","SIAE_HUMAN","Sialate O-acetylesterase",null,"SIAE"]
["25.8883","26.1698","25.8423","25.7222",{"$nulls":3},"cytoplasmic translation;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal large subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","DNA binding;mRNA binding;protein homodimerization activity;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleus","Ribosome",null,null,16,16,16,52,52,52,"29.225",0,"115.06",10453000000,340,"0.60559",1,"0.246836","1.61351","sp|P18124|RL7_HUMAN;tr|A8MUD9|A8MUD9_HUMAN;tr|C9JIJ5|C9JIJ5_HUMAN;tr|C9JZ88|C9JZ88_HUMAN","sp|P18124|RL7_HUMAN;tr|A8MUD9|A8MUD9_HUMAN",1115,"P18124","RL7_HUMAN","60S ribosomal protein L7",null,"RPL7"]
["18.2308","17.8138","18.257","17.2951",{"$nulls":3},"cell adhesion;mRNA 3'-end processing;mRNA export from nucleus;mRNA polyadenylation;mRNA splicing, via spliceosome;positive regulation of protein dephosphorylation;termination of RNA polymerase II transcription",null,"bicellular tight junction;cytoplasm;cytoskeleton;cytosol;nuclear stress granule;nucleoplasm;plasma membrane","mRNA surveillance pathway;Tight junction",null,null,12,12,12,"17.8","17.8","17.8","141.15",0,"35.574",151500000,23,"0.164491",1,"0.246296","0.469847","sp|Q92797|SYMPK_HUMAN;tr|A0A087WUE9|A0A087WUE9_HUMAN;tr|M0R3C7|M0R3C7_HUMAN;tr|M0R1C2|M0R1C2_HUMAN;tr|M0R180|M0R180_HUMAN;tr|M0QXP5|M0QXP5_HUMAN;tr|M0R039|M0R039_HUMAN","sp|Q92797|SYMPK_HUMAN;tr|A0A087WUE9|A0A087WUE9_HUMAN;tr|M0R3C7|M0R3C7_HUMAN",3533,"Q92797","SYMPK_HUMAN","Symplekin",null,"SYMPK"]
["19.7621","20.6221","19.3487","20.5462",{"$nulls":3},"autophagosome assembly;autophagy of mitochondrion;autophagy of nucleus;cellular protein modification process;macroautophagy;mitochondrial fragmentation involved in apoptotic process;negative regulation of phagocytosis;protein targeting to membrane;protein ubiquitination;regulation of cilium assembly","Atg12 transferase activity;Atg8 ligase activity;enzyme binding;ligase activity;ubiquitin-like protein transferase activity","cytoplasmic ubiquitin ligase complex;cytosol","Autophagy - animal;Autophagy - other;Kaposi sarcoma-associated herpesvirus infection",null,null,4,4,4,"15.9","15.9","15.9","35.864",0,"13.585",124570000,9,"0.11264",1,"0.244636","0.331863","sp|Q9NT62|ATG3_HUMAN;tr|F8WDI0|F8WDI0_HUMAN","sp|Q9NT62|ATG3_HUMAN;tr|F8WDI0|F8WDI0_HUMAN",4448,"Q9NT62","ATG3_HUMAN","Ubiquitin-like-conjugating enzyme ATG3",null,"ATG3"]
["19.1954","19.1343","19.4805","18.3664",{"$nulls":9},2,2,2,"7.4","7.4","7.4","37.971",0,"9.0224",66447000,11,"0.150319",1,"0.241408","0.432697","tr|A0A0A0MRI1|A0A0A0MRI1_HUMAN;sp|Q8IXQ4|GPAM1_HUMAN","tr|A0A0A0MRI1|A0A0A0MRI1_HUMAN;sp|Q8IXQ4|GPAM1_HUMAN",3149,"A0A0A0MRI1","A0A0A0MRI1_HUMAN",null,null,"GPALPP1"]
["25.1377","24.5898","25.1778","24.0694",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational elongation;translational initiation;viral transcription","structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;membrane","Ribosome",null,null,6,6,5,"91.3","91.3","76.5","11.665",0,"94.441",1203600000,43,"0.133621",1,"0.240129","0.388416","sp|P05387|RLA2_HUMAN;tr|H0YDD8|H0YDD8_HUMAN","sp|P05387|RLA2_HUMAN;tr|H0YDD8|H0YDD8_HUMAN",863,"P05387","RLA2_HUMAN","60S acidic ribosomal protein P2",null,"RPLP2"]
["16.5493","16.8374","16.8068","16.1015",{"$nulls":3},"activation of MAPK activity;Fc-epsilon receptor signaling pathway;heart development;I-kappaB kinase/NF-kappaB signaling;JNK cascade;MyD88-dependent toll-like receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway;negative regulation of autophagy;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of protein kinase activity;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway","K63-linked polyubiquitin modification-dependent protein binding;metal ion binding","cytosol;endosome membrane;nucleoplasm;plasma membrane","Epstein-Barr virus infection;Hepatitis B;Herpes simplex virus 1 infection;Human immunodeficiency virus 1 infection;IL-17 signaling pathway;Leishmaniasis;MAPK signaling pathway;Measles;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Osteoclast differentiation;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Yersinia infection",null,null,4,4,4,"7.8","7.8","7.8","76.493",0,"11.084",17751000,7,"0.226092",1,"0.239197","0.627976","sp|Q9NYJ8|TAB2_HUMAN;tr|U3KQR0|U3KQR0_HUMAN","sp|Q9NYJ8|TAB2_HUMAN",4567,"Q9NYJ8","TAB2_HUMAN","TGF-beta-activated kinase 1 and MAP3K7-binding protein 2",null,"TAB2"]
["23.0708","23.7618","23.1042","23.2516",{"$nulls":3},"apoptotic process;cellular response to interleukin-4;cochlea development;DNA replication;DNA replication initiation;DNA unwinding involved in DNA replication;G1/S transition of mitotic cell cycle;nucleosome assembly","ATP binding;DNA binding;DNA helicase activity;DNA replication origin binding;enzyme binding;histone binding;metal ion binding","chromatin;cytoplasm;cytosol;MCM complex;microtubule cytoskeleton;nuclear chromosome, telomeric region;nuclear origin of replication recognition complex;nucleoplasm;nucleus","Cell cycle;DNA replication",null,null,31,31,31,"45.4","45.4","45.4","101.89",0,"323.31",3856400000,197,"0.244658",1,"0.238422","0.674908","sp|P49736|MCM2_HUMAN;tr|H0Y8E6|H0Y8E6_HUMAN;tr|F8WDM3|F8WDM3_HUMAN;tr|C9J013|C9J013_HUMAN;tr|C9JZ21|C9JZ21_HUMAN;tr|H7C4N9|H7C4N9_HUMAN","sp|P49736|MCM2_HUMAN;tr|H0Y8E6|H0Y8E6_HUMAN",1592,"P49736","MCM2_HUMAN","DNA replication licensing factor MCM2",null,"MCM2"]
["17.0731","18.011","17.4723","17.138",{"$nulls":9},5,5,5,"12.9","12.9","12.9","57.891",0,"17.094",268670000,34,"0.166759",1,"0.236865","0.475758","sp|Q8TBB5|KLDC4_HUMAN;tr|H3BQH3|H3BQH3_HUMAN;tr|Q9UF94|Q9UF94_HUMAN","sp|Q8TBB5|KLDC4_HUMAN;tr|H3BQH3|H3BQH3_HUMAN",3365,"Q8TBB5","KLDC4_HUMAN","Kelch domain-containing protein 4",null,"KLHDC4"]
["21.7596","22.4636","22.2029","21.5481",{"$nulls":3},"protein deneddylation",null,"COP9 signalosome;nucleoplasm",{"$nulls":3},5,5,5,"24.5","24.5","24.5","36.064",0,"31.837",444890000,20,"0.172626",1,"0.236056","0.491014","tr|E7EM64|E7EM64_HUMAN;sp|Q7L5N1|CSN6_HUMAN;tr|H7C3T0|H7C3T0_HUMAN","tr|E7EM64|E7EM64_HUMAN;sp|Q7L5N1|CSN6_HUMAN",2971,"E7EM64","E7EM64_HUMAN",null,null,"COPS6"]
["18.582","16.0216","18.7791","15.353",{"$nulls":3},"endocytosis;endosomal vesicle fusion;endosome localization;Golgi to lysosome transport;positive regulation of pinocytosis;retrograde transport, endosome to Golgi","metal ion binding;phosphatidylinositol phosphate binding;Rab GTPase binding","cytosol;early endosome;endosome;endosome membrane;extracellular exosome;intracellular membrane-bounded organelle;lysosomal membrane;macropinosome;membrane",{"$nulls":3},3,3,3,6,6,6,"128.4",0,"38.754",90570000,9,"0.0351348",1,"0.235754","0.110239","sp|Q9P2R3|ANFY1_HUMAN;tr|I3L1Z9|I3L1Z9_HUMAN","sp|Q9P2R3|ANFY1_HUMAN",4648,"Q9P2R3","ANFY1_HUMAN","Rabankyrin-5 {ECO:0000303|PubMed:15328530}","ank-5 {ECO:0000303|PubMed:22284051}","ANKFY1"]
["17.9561","19.1791","19.3125","17.3532",{"$nulls":4},"chaperone binding",{"$nulls":4},4,4,4,"19.4","19.4","19.4","38.76",0,"14.613",60661000,7,"0.0666595",1,"0.234776","0.203297","tr|J3QTA2|J3QTA2_HUMAN;sp|Q99933|BAG1_HUMAN;tr|C9JYK5|C9JYK5_HUMAN;tr|F1LLU6|F1LLU6_HUMAN","tr|J3QTA2|J3QTA2_HUMAN;sp|Q99933|BAG1_HUMAN;tr|C9JYK5|C9JYK5_HUMAN",3893,"J3QTA2","J3QTA2_HUMAN",null,null,"BAG1"]
["22.2148","22.731","22.4677","22.0127",{"$nulls":3},"regulation of translational initiation;translational initiation","RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;extracellular exosome;membrane","Measles;RNA transport",null,null,15,15,15,"49.4","49.4","49.4","39.93",0,"62.301",1140200000,59,"0.24519",1,"0.232663","0.676247","sp|O15372|EIF3H_HUMAN;tr|B3KS98|B3KS98_HUMAN;tr|A0A087WZK9|A0A087WZK9_HUMAN;tr|E5RJT0|E5RJT0_HUMAN;tr|E5RGU4|E5RGU4_HUMAN;tr|E5RFW7|E5RFW7_HUMAN;tr|E5RFH0|E5RFH0_HUMAN;tr|E5RHC7|E5RHC7_HUMAN;tr|E5RH59|E5RH59_HUMAN","sp|O15372|EIF3H_HUMAN;tr|B3KS98|B3KS98_HUMAN;tr|A0A087WZK9|A0A087WZK9_HUMAN",357,"O15372","EIF3H_HUMAN","Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007}","IF3h {ECO:0000255|HAMAP-Rule:MF_03007}","EIF3H"]
["20.5956","21.0852","20.6094","20.6096",{"$nulls":3},"intracellular distribution of mitochondria;mitochondrion organization","mRNA binding","cytoplasm",{"$nulls":3},26,26,1,"29.9","29.9","1.1","146.67",0,"143.24",1039500000,117,"0.351496",1,"0.230884","0.943183","sp|O75153|CLU_HUMAN","sp|O75153|CLU_HUMAN",531,"O75153","CLU_HUMAN","Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013}",null,"CLUH"]
["26.7886","27.4115","27.0147","26.7242",{"$nulls":4},"DNA binding","nucleus",{"$nulls":3},11,11,8,"48.1","48.1","30.4","18.311",0,"237.95",6362700000,406,"0.243112",1,"0.230614","0.671008","tr|Q5T7C4|Q5T7C4_HUMAN;sp|P09429|HMGB1_HUMAN;sp|B2RPK0|HGB1A_HUMAN","tr|Q5T7C4|Q5T7C4_HUMAN;sp|P09429|HMGB1_HUMAN;sp|B2RPK0|HGB1A_HUMAN",946,"Q5T7C4","Q5T7C4_HUMAN",null,null,"HMGB1"]
["23.3253","22.7816","23.7089","21.9393",{"$nulls":3},"RNA metabolic process","RNA binding;sequence-specific DNA binding;single-stranded DNA binding",{"$nulls":4},9,9,9,"45.3","45.3","45.3","25.572",0,"40.536",1133900000,63,"0.0822619",1,"0.229318","0.247749","tr|E9PGT1|E9PGT1_HUMAN;sp|Q15631|TSN_HUMAN;tr|H7C1D4|H7C1D4_HUMAN;tr|A0A0J9YVW2|A0A0J9YVW2_HUMAN","tr|E9PGT1|E9PGT1_HUMAN;sp|Q15631|TSN_HUMAN;tr|H7C1D4|H7C1D4_HUMAN",2504,"E9PGT1","E9PGT1_HUMAN",null,null,"TSN"]
["18.8722","19.8831","19.1918","19.1077",{"$nulls":3},"nucleocytoplasmic transport","structural constituent of nuclear pore","nuclear pore",{"$nulls":3},16,16,16,"16.1","16.1","16.1","148.09",0,"35.619",273130000,46,"0.156657",1,"0.227917","0.449356","tr|E9PF10|E9PF10_HUMAN;sp|O75694|NU155_HUMAN","tr|E9PF10|E9PF10_HUMAN;sp|O75694|NU155_HUMAN",605,"E9PF10","E9PF10_HUMAN",null,null,"NUP155"]
["16.6446","17.6938","16.7734","17.113",{"$nulls":3},"protein dephosphorylation;protein phosphorylation;signal transduction","protein phosphatase regulator activity","protein phosphatase 4 complex",{"$nulls":3},5,5,5,"7.7","7.7","7.7",107,0,"8.9745",47588000,7,"0.141677",1,"0.226007","0.409853","sp|Q8TF05|PP4R1_HUMAN;tr|J3QL26|J3QL26_HUMAN;tr|J3KSB0|J3KSB0_HUMAN;tr|J3QLA6|J3QLA6_HUMAN;tr|J3QQV0|J3QQV0_HUMAN;tr|J3KRU1|J3KRU1_HUMAN","sp|Q8TF05|PP4R1_HUMAN",3404,"Q8TF05","PP4R1_HUMAN","Serine/threonine-protein phosphatase 4 regulatory subunit 1",null,"PPP4R1"]
[1,"19.0763",1,"18.6255",{"$nulls":9},1,1,1,"4.5","4.5","4.5","41.548","0.0048583","2.8046",37973000,2,"0.00551796",1,"0.225408","0.0178562","tr|B9TX33|B9TX33_HUMAN;sp|Q71SY5|MED25_HUMAN","tr|B9TX33|B9TX33_HUMAN;sp|Q71SY5|MED25_HUMAN",2953,"B9TX33","B9TX33_HUMAN"]
["20.7964","19.1097","21.0062","18.4497",{"$nulls":3},"7-methylguanosine mRNA capping;cellular response to leukemia inhibitory factor;transcription from RNA polymerase II promoter","mRNA (guanine-N7-)-methyltransferase activity;RNA binding","fibrillar center;mRNA cap binding complex;mRNA cap methyltransferase complex;nucleoplasm;nucleus;receptor complex","mRNA surveillance pathway",null,null,7,7,7,"22.7","22.7","22.7","54.843",0,"28.045",271890000,14,"0.0473909",1,"0.225096","0.146987","sp|O43148|MCES_HUMAN;tr|K7EP06|K7EP06_HUMAN;tr|K7EPP5|K7EPP5_HUMAN","sp|O43148|MCES_HUMAN;tr|K7EP06|K7EP06_HUMAN",373,"O43148","MCES_HUMAN","mRNA cap guanine-N7 methyltransferase",null,"RNMT"]
["19.4175","19.0187","19.5387","18.4498",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","cadherin binding","mitochondrion;nucleoplasm",{"$nulls":3},5,5,5,"14.7","14.7","14.7","33.216",0,"10.137",306450000,21,"0.132742",1,"0.223851","0.38607","sp|Q9NWB6|ARGL1_HUMAN;tr|X6R9F1|X6R9F1_HUMAN","sp|Q9NWB6|ARGL1_HUMAN",4513,"Q9NWB6","ARGL1_HUMAN","Arginine and glutamate-rich protein 1",null,"ARGLU1"]
["19.1887","18.5874","18.5936","18.7364",{"$nulls":3},"activation of protein kinase activity;cellular response to extracellular stimulus;estrous cycle;negative regulation of gene expression;negative regulation of neuron apoptotic process;negative regulation of protein binding;negative regulation of synaptic transmission;nitric oxide homeostasis;positive regulation of axon extension;positive regulation of cGMP biosynthetic process;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of synapse assembly;regulation of protein ADP-ribosylation;regulation of transcription, DNA-templated;response to carbohydrate;response to inorganic substance;short-term memory;transcription, DNA-templated","beta-tubulin binding;chromatin binding;copper ion binding;DNA binding;peptide binding","axon;cytoplasm;dendrite;extracellular space;neuronal cell body;nucleus",{"$nulls":3},31,31,31,"35.8","35.8","35.8","123.56",0,"147.6",1890800000,253,"0.263322",1,"0.223083","0.721891","sp|Q9H2P0|ADNP_HUMAN;tr|E9PQK8|E9PQK8_HUMAN","sp|Q9H2P0|ADNP_HUMAN",4175,"Q9H2P0","ADNP_HUMAN","Activity-dependent neuroprotector homeobox protein",null,"ADNP"]
["24.5101","24.7582","24.8204","24.0018",{"$nulls":3},"regulation of microtubule polymerization or depolymerization",{"$nulls":5},2,1,1,"11.3",6,6,"19.574","0.0002359","5.154",2257800000,10,"0.184451",1,"0.223079","0.521604","tr|E5RGX5|E5RGX5_HUMAN;sp|Q93045|STMN2_HUMAN","tr|E5RGX5|E5RGX5_HUMAN;sp|Q93045|STMN2_HUMAN",3567,"E5RGX5","E5RGX5_HUMAN","Stathmin {ECO:0000256|RuleBase:RU004388}",null,"STMN2"]
["19.5707","20.8978","19.8731","20.1519",{"$nulls":3},"cell adhesion;cell migration;epithelial tube formation;glomerular visceral epithelial cell development;negative regulation of cell adhesion;negative regulation of cell-cell adhesion;positive regulation of cell migration;positive regulation of cell-cell adhesion mediated by integrin;regulation of microvillus assembly",null,"apical plasma membrane;cytoplasm;extracellular exosome;extracellular space;filopodium;integral component of plasma membrane;intracellular membrane-bounded organelle;lamellipodium;membrane raft;microtubule organizing center;microvillus membrane;nucleolus;plasma membrane;ruffle;slit diaphragm",{"$nulls":3},5,5,5,"13.4","13.4","13.4","58.635",0,"23.849",203980000,17,"0.110883",1,"0.221757","0.327075","sp|O00592|PODXL_HUMAN","sp|O00592|PODXL_HUMAN",246,"O00592","PODXL_HUMAN","Podocalyxin",null,"PODXL"]
["22.6796","22.9752","22.8596","22.354",{"$nulls":3},"negative regulation of cell proliferation","cadherin binding;RNA binding;zinc ion binding","cell junction;cytosol;focal adhesion;nucleus;plasma membrane;protein complex",{"$nulls":3},12,12,12,"36.6","36.6","36.6","47.996",0,"68.892",1359600000,65,"0.275895",1,"0.220625","0.753466","sp|Q9UGI8|TES_HUMAN;tr|F8W7T0|F8W7T0_HUMAN;tr|H7BYK1|H7BYK1_HUMAN;tr|F8WDI4|F8WDI4_HUMAN","sp|Q9UGI8|TES_HUMAN",4702,"Q9UGI8","TES_HUMAN","Testin",null,"TES"]
["21.4421","21.8422","21.6461","21.1999",{"$nulls":3},"acrosome assembly;actin cytoskeleton organization;adult locomotory behavior;ameboidal-type cell migration;auditory receptor cell development;brain morphogenesis;cerebral cortex development;cerebral cortex neuron differentiation;chemical synaptic transmission;ciliary basal body-plasma membrane docking;cochlea development;corpus callosum morphogenesis;cortical microtubule organization;establishment of centrosome localization;establishment of mitotic spindle orientation;establishment of planar polarity of embryonic epithelium;G2/M transition of mitotic cell cycle;germ cell development;hippocampus development;layer formation in cerebral cortex;learning or memory;lipid catabolic process;maintenance of centrosome location;microtubule cytoskeleton organization;microtubule cytoskeleton organization involved in establishment of planar polarity;microtubule organizing center organization;microtubule-based process;negative regulation of JNK cascade;negative regulation of neuron projection development;neuroblast proliferation;neuromuscular process controlling balance;neuron migration;nuclear envelope disassembly;nuclear migration;osteoclast development;platelet activating factor metabolic process;positive regulation of axon extension;positive regulation of cytokine-mediated signaling pathway;positive regulation of dendritic spine morphogenesis;positive regulation of embryonic development;positive regulation of mitotic cell cycle;protein secretion;regulation of G2/M transition of mitotic cell cycle;regulation of GTPase activity;regulation of microtubule cytoskeleton organization;regulation of microtubule motor activity;retrograde axonal transport;sister chromatid cohesion;stem cell division;transmission of nerve impulse;vesicle transport along microtubule","dynactin binding;dynein complex binding;dynein intermediate chain binding;heparin binding;microtubule binding;phospholipase A2 activity;phospholipase binding;phosphoprotein binding;protein homodimerization activity","astral microtubule;axon cytoplasm;cell cortex;cell leading edge;central region of growth cone;centrosome;cytosol;extracellular exosome;kinesin complex;kinetochore;microtubule associated complex;motile cilium;neuronal cell body;nuclear envelope;nuclear membrane;perinuclear region of cytoplasm;stereocilium","Ether lipid metabolism;Metabolic pathways",null,null,9,9,9,"23.2","23.2","23.2","46.637",0,"48.021",572760000,39,"0.267135",1,"0.219156","0.731472","sp|P43034|LIS1_HUMAN;tr|I3L495|I3L495_HUMAN;tr|I3L3N5|I3L3N5_HUMAN","sp|P43034|LIS1_HUMAN",1484,"P43034","LIS1_HUMAN","Platelet-activating factor acetylhydrolase IB subunit alpha {ECO:0000255|HAMAP-Rule:MF_03141}",null,"PAFAH1B1"]
["21.7054","22.2043","21.8807","21.5936",{"$nulls":3},"mRNA processing;mRNA splicing, via spliceosome;negative regulation of protein catabolic process;protein complex assembly;RNA splicing;RNA splicing, via transesterification reactions","protein complex binding;RNA binding","catalytic step 2 spliceosome;nucleolus;nucleoplasm;nucleus;small nuclear ribonucleoprotein complex;spliceosomal complex;U12-type spliceosomal complex","Spliceosome",null,null,28,28,28,"31.6","31.6","31.6","135.58",0,"199.75",2562800000,238,"0.277036",1,"0.217677","0.75633","sp|Q15393|SF3B3_HUMAN;tr|I3L4G7|I3L4G7_HUMAN;tr|J3QRB2|J3QRB2_HUMAN;tr|J3QL37|J3QL37_HUMAN;tr|H3BMB0|H3BMB0_HUMAN;tr|J3QKV4|J3QKV4_HUMAN","sp|Q15393|SF3B3_HUMAN",2484,"Q15393","SF3B3_HUMAN","Splicing factor 3B subunit 3",null,"SF3B3"]
["20.963","21.3905","20.6741","21.2453",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein ubiquitination;osteoblast differentiation;positive regulation of cell proliferation;positive regulation of glial cell proliferation;protein K69-linked ufmylation;protein ufmylation;regulation of intracellular estrogen receptor signaling pathway;regulation of proteasomal ubiquitin-dependent protein catabolic process;regulation of protein localization;response to endoplasmic reticulum stress;response to L-glutamate","ligase activity;UFM1 transferase activity","cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;membrane;neuron projection;protein complex",{"$nulls":3},34,34,34,"51.1","51.1","51.1","89.594",0,"278.05",7206000000,489,"0.218396",1,"0.21706","0.608447","sp|O94874|UFL1_HUMAN;sp|Q92845|KIFA3_HUMAN","sp|O94874|UFL1_HUMAN",661,"O94874","UFL1_HUMAN","E3 UFM1-protein ligase 1 {ECO:0000305}",null,"UFL1"]
["23.6947","24.2619","23.845","23.6781",{"$nulls":3},"apoptotic process;BMP signaling pathway;cellular protein modification process;DNA repair;MyD88-independent toll-like receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;positive regulation of protein targeting to mitochondrion;proteasome-mediated ubiquitin-dependent protein catabolic process;protein autoubiquitination;protein K11-linked ubiquitination;protein K48-linked ubiquitination;protein monoubiquitination;protein polyubiquitination;protein ubiquitination;regulation of transcription from RNA polymerase II promoter in response to hypoxia;TRIF-dependent toll-like receptor signaling pathway;ubiquitin-dependent protein catabolic process","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin-protein transferase activity","cytosol;endosome membrane;extracellular exosome;nucleoplasm;plasma membrane","Protein processing in endoplasmic reticulum;Shigellosis;Ubiquitin mediated proteolysis",null,null,3,3,2,"24.5","24.5","12.2","16.687",0,"9.1538",433170000,14,"0.267796",1,"0.216746","0.733131","sp|P61077|UB2D3_HUMAN;tr|A0A087WY85|A0A087WY85_HUMAN;tr|D6RAW0|D6RAW0_HUMAN;tr|D6RA11|D6RA11_HUMAN;tr|D6RFM0|D6RFM0_HUMAN;tr|D6RAH7|D6RAH7_HUMAN;tr|H9KV45|H9KV45_HUMAN;tr|A0A0A0MQU3|A0A0A0MQU3_HUMAN;sp|P62837|UB2D2_HUMAN;tr|D6R9F6|D6R9F6_HUMAN;tr|D6R933|D6R933_HUMAN;tr|D6RGD0|D6RGD0_HUMAN;tr|D6R980|D6R980_HUMAN;tr|D6RIZ3|D6RIZ3_HUMAN","sp|P61077|UB2D3_HUMAN;tr|A0A087WY85|A0A087WY85_HUMAN;tr|D6RAW0|D6RAW0_HUMAN;tr|D6RA11|D6RA11_HUMAN;tr|D6RFM0|D6RFM0_HUMAN;tr|D6RAH7|D6RAH7_HUMAN;tr|H9KV45|H9KV45_HUMAN;tr|A0A0A0MQU3|A0A0A0MQU3_HUMAN;sp|P62837|UB2D2_HUMAN",1827,"P61077","UB2D3_HUMAN","Ubiquitin-conjugating enzyme E2 D3",null,"UBE2D3"]
["16.3813","16.3915","16.8241","15.5167",{"$nulls":4},"actin filament binding;ATP binding;motor activity","myosin complex",{"$nulls":3},24,1,1,29,"1.8","1.8","113.78","0.0010977","3.9038",41860000,8,"0.112103",1,"0.216005","0.330403","tr|M0QY43|M0QY43_HUMAN","tr|M0QY43|M0QY43_HUMAN",5288,"M0QY43","M0QY43_HUMAN",null,null,"MYH14"]
["19.7197","20.2246","19.9831","19.5298",{"$nulls":3},"double-strand break repair;female meiosis I;male meiosis I;mitotic spindle assembly checkpoint;oocyte maturation;oogenesis;reciprocal meiotic recombination;spermatid development;spermatogenesis;synaptonemal complex assembly;transcription from RNA polymerase II promoter","ATP binding;identical protein binding;transcription cofactor activity","male germ cell nucleus;nucleus",{"$nulls":3},8,8,8,"23.8","23.8","23.8","48.55",0,"42.599",291800000,30,"0.229111",1,"0.215663","0.635622","sp|Q15645|PCH2_HUMAN;tr|H0YAL2|H0YAL2_HUMAN","sp|Q15645|PCH2_HUMAN",2508,"Q15645","PCH2_HUMAN","Pachytene checkpoint protein 2 homolog",null,"TRIP13"]
["15.7712","16.8885","15.9448","16.284",{"$nulls":3},"cellular response to interleukin-1;cellular response to lipopolysaccharide;cellular response to tumor necrosis factor;innate immune response;mRNA splicing, via spliceosome;multicellular organism development;negative regulation of interferon-beta production;negative regulation of interleukin-8 production;negative regulation of lipopolysaccharide-mediated signaling pathway;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein phosphorylation;negative regulation of toll-like receptor signaling pathway;negative regulation of tumor necrosis factor production;negative regulation of type I interferon-mediated signaling pathway","RNA binding","catalytic step 2 spliceosome;cytosol;extracellular exosome;nuclear speck;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"9.6","9.6","9.6","88.701",0,"33.742",160520000,22,"0.126343",1,"0.215385","0.368924","sp|Q8WUQ7|CATIN_HUMAN;tr|K7ENY9|K7ENY9_HUMAN","sp|Q8WUQ7|CATIN_HUMAN",3427,"Q8WUQ7","CATIN_HUMAN","Cactin",null,"CACTIN"]
["17.2671","18.0334","17.8363","17.0349",{"$nulls":3},"regulation of insulin secretion","protein domain specific binding","cytosol;Golgi membrane;intracellular membrane-bounded organelle;secretory granule membrane",{"$nulls":3},7,7,7,"24.6","24.6","24.6","53.242",0,"10.876",56193000,12,"0.133151",1,"0.214656","0.387162","tr|E9PDL4|E9PDL4_HUMAN;sp|Q05084|ICA69_HUMAN;tr|B9ZVM7|B9ZVM7_HUMAN;tr|Q6LCR0|Q6LCR0_HUMAN;tr|E7ENI6|E7ENI6_HUMAN;tr|C9IZC7|C9IZC7_HUMAN;tr|F8WET5|F8WET5_HUMAN;tr|Q6LCT9|Q6LCT9_HUMAN;tr|C9J8Y3|C9J8Y3_HUMAN;tr|C9J3Y4|C9J3Y4_HUMAN","tr|E9PDL4|E9PDL4_HUMAN;sp|Q05084|ICA69_HUMAN",2099,"E9PDL4","E9PDL4_HUMAN",null,null,"ICA1"]
["20.5229","21.027","21.1823","19.9421",{"$nulls":3},"ATP-dependent chromatin remodeling;cell cycle;cell differentiation;chromatin remodeling;covalent chromatin modification;DNA integration;DNA repair;negative regulation of cell proliferation;negative regulation of histone H3-K9 dimethylation;negative regulation of histone H3-K9 trimethylation;nervous system development;nucleosome disassembly;positive regulation by host of viral transcription;positive regulation of DNA binding transcription factor activity;positive regulation of glucose mediated signaling pathway;positive regulation of histone H3-K9 acetylation;positive regulation of histone H4 acetylation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;regulation of transcription from RNA polymerase II promoter;single stranded viral RNA replication via double stranded DNA intermediate;transcription, DNA-templated","DNA binding;p53 binding;RNA polymerase I CORE element sequence-specific DNA binding;Tat protein binding;transcription coactivator activity","fibrillar center;intracellular membrane-bounded organelle;nBAF complex;npBAF complex;nuclear chromatin;nucleolus;nucleoplasm;nucleus;protein complex;SWI/SNF complex","Hepatocellular carcinoma;Thermogenesis",null,null,15,15,1,"61.6","61.6","3.9","44.141",0,"323.31",2068100000,155,"0.10747",1,"0.212704","0.31775","sp|Q12824|SNF5_HUMAN;tr|B5MCL5|B5MCL5_HUMAN;tr|C9JTA6|C9JTA6_HUMAN;tr|A0A0G2JSE9|A0A0G2JSE9_HUMAN","sp|Q12824|SNF5_HUMAN;tr|B5MCL5|B5MCL5_HUMAN",2163,"Q12824","SNF5_HUMAN","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1",null,"SMARCB1"]
["19.7762","20.0329","20.1868","19.1978",{"$nulls":3},"chromatin remodeling","DNA binding;DNA-directed DNA polymerase activity;protein heterodimerization activity","CHRAC;epsilon DNA polymerase complex",{"$nulls":3},3,3,3,"39.7","39.7","39.7","14.71",0,"11.936",68860000,17,"0.143833",1,"0.212314","0.415567","sp|Q9NRG0|CHRC1_HUMAN;tr|E5RGS9|E5RGS9_HUMAN;tr|H0YBP8|H0YBP8_HUMAN","sp|Q9NRG0|CHRC1_HUMAN;tr|E5RGS9|E5RGS9_HUMAN",4418,"Q9NRG0","CHRC1_HUMAN","Chromatin accessibility complex protein 1","HRAC-1","CHRAC1"]
["23.0484","23.2003","23.2476","22.5828",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone",null,"mitochondrial respiratory chain complex I;mitochondrion",{"$nulls":3},6,6,6,"42.9","42.9","42.9","20.383",0,"38.623",595760000,32,"0.220431",1,"0.209205","0.613613","tr|E9PH64|E9PH64_HUMAN;sp|Q9Y6M9|NDUB9_HUMAN;tr|E7EWZ0|E7EWZ0_HUMAN;tr|E9PF49|E9PF49_HUMAN","tr|E9PH64|E9PH64_HUMAN;sp|Q9Y6M9|NDUB9_HUMAN;tr|E7EWZ0|E7EWZ0_HUMAN;tr|E9PF49|E9PF49_HUMAN",5107,"E9PH64","E9PH64_HUMAN",null,null,"NDUFB9"]
["23.4142","23.6942","23.4796","23.2138",{"$nulls":3},"brain development;glutaminyl-tRNA aminoacylation;negative regulation of apoptotic signaling pathway;negative regulation of protein kinase activity;negative regulation of stress-activated MAPK cascade;negative regulation of transcription, DNA-templated;tRNA aminoacylation for protein translation","ATP binding;glutamine-tRNA ligase activity;protein kinase binding;protein kinase inhibitor activity","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;mitochondrial matrix;protein complex","Aminoacyl-tRNA biosynthesis;Metabolic pathways",null,null,43,42,42,"60.4","59.4","59.4","87.798",0,"323.31",10717000000,643,"0.403421",1,"0.207487","1.07461","sp|P47897|SYQ_HUMAN;tr|H7C0R3|H7C0R3_HUMAN;tr|C9J165|C9J165_HUMAN;tr|F2Z2V6|F2Z2V6_HUMAN","sp|P47897|SYQ_HUMAN",1530,"P47897","SYQ_HUMAN","Glutamine--tRNA ligase",null,"QARS"]
["20.6083","20.7485","20.5692","20.3754",{"$nulls":3},"cell proliferation;positive regulation of pri-miRNA transcription from RNA polymerase II promoter;positive regulation of protein localization to chromosome, telomeric region;positive regulation of protein sumoylation;positive regulation of telomere maintenance;regulation of cell proliferation;ribosome biogenesis;stem cell division;stem cell population maintenance","GTP binding;GTPase activity;mRNA 5'-UTR binding;RNA binding","extracellular space;membrane;nuclear body;nucleolus;nucleus","Ribosome biogenesis in eukaryotes",null,null,26,26,26,"49.2","49.2","49.2","61.992",0,"323.31",4576000000,227,"0.643883",1,"0.206065","1.7229","sp|Q9BVP2|GNL3_HUMAN;tr|C9JYH9|C9JYH9_HUMAN;tr|C9JZT7|C9JZT7_HUMAN;tr|B4DMU5|B4DMU5_HUMAN","sp|Q9BVP2|GNL3_HUMAN",4014,"Q9BVP2","GNL3_HUMAN","Guanine nucleotide-binding protein-like 3",null,"GNL3"]
["15.9386",1,"15.5267",1,{"$nulls":3},"cellular response to laminar fluid shear stress;cellular response to starvation;cholesterol metabolic process;lipid metabolic process;negative regulation of cholesterol efflux;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cholesterol storage;positive regulation of protein targeting to mitochondrion;positive regulation of transcription from RNA polymerase II promoter;regulation of autophagy of mitochondrion;regulation of cholesterol biosynthetic process;regulation of cholesterol homeostasis;regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter;response to low-density lipoprotein particle stimulus;transcription, DNA-templated","E-box binding;protein C-terminus binding;protein dimerization activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane;intracellular membrane-bounded organelle;mitochondrion;nucleoplasm;nucleus;SREBP-SCAP-Insig complex",{"$nulls":3},3,3,3,"4.2","4.2","4.2","123.69","0.0019169","3.469",25276000,4,"0.00611225",1,"0.205935","0.0197661","sp|Q12772|SRBP2_HUMAN;tr|H0Y7E5|H0Y7E5_HUMAN","sp|Q12772|SRBP2_HUMAN;tr|H0Y7E5|H0Y7E5_HUMAN",2155,"Q12772","SRBP2_HUMAN","Sterol regulatory element-binding protein 2","REBP-2","SREBF2"]
["16.6752","16.5144","17.0145","15.7646",{"$nulls":3},"regulation of transcription from RNA polymerase II promoter","translation elongation factor activity","elongin complex",{"$nulls":3},19,19,19,"29.9","29.9","29.9","87.229",0,"152.71",1139400000,114,"0.110395",1,"0.205265","0.325745","tr|A0A024RAC6|A0A024RAC6_HUMAN;sp|Q14241|ELOA1_HUMAN","tr|A0A024RAC6|A0A024RAC6_HUMAN;sp|Q14241|ELOA1_HUMAN",5123,"A0A024RAC6","A0A024RAC6_HUMAN",null,null,"ELOA"]
["20.4562","20.5968","20.5775","20.0661",{"$nulls":3},"DNA replication;negative regulation of transcription from RNA polymerase II promoter;odontogenesis of dentin-containing tooth;positive regulation of transcription from RNA polymerase II promoter;transcription from RNA polymerase II promoter","DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","fibrillar center;nucleus",{"$nulls":3},7,7,5,"20.9","20.9","16.3","55.674",0,"194.3",877310000,43,"0.283331",1,"0.204753","0.772121","sp|P08651|NFIC_HUMAN","sp|P08651|NFIC_HUMAN",929,"P08651","NFIC_HUMAN","Nuclear factor 1 C-type","F1-C;uclear factor 1/C","NFIC"]
["18.8269","18.413","18.7809","18.0533",{"$nulls":5},"intracellular membrane-bounded organelle;nucleoplasm;plasma membrane",{"$nulls":3},6,6,6,14,14,14,"82.89",0,"34.323",125470000,22,"0.170176",1,"0.202841","0.484651","tr|A0A087X0M4|A0A087X0M4_HUMAN;sp|Q9BWU0|NADAP_HUMAN;tr|H7C256|H7C256_HUMAN;tr|A0A087WWF4|A0A087WWF4_HUMAN","tr|A0A087X0M4|A0A087X0M4_HUMAN;sp|Q9BWU0|NADAP_HUMAN",5135,"A0A087X0M4","A0A087X0M4_HUMAN",null,null,"SLC4A1AP"]
["17.9048","18.2298","17.2747","18.4558",{"$nulls":3},"cardiac muscle cell proliferation;coronary artery morphogenesis;covalent chromatin modification;embryonic organ development;heart morphogenesis;homeostatic process;negative regulation of cell migration;negative regulation of cell proliferation;nucleosome disassembly;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;metal ion binding","nucleoplasm;plasma membrane","Hepatocellular carcinoma",null,null,29,29,29,"21.6","21.6","21.6","197.39",0,"117.15",1887700000,195,"0.111929",1,"0.202079","0.329927","sp|Q68CP9|ARID2_HUMAN;tr|F8WCU9|F8WCU9_HUMAN;tr|F8W108|F8W108_HUMAN;tr|F8VWP4|F8VWP4_HUMAN;tr|A0A087WY37|A0A087WY37_HUMAN","sp|Q68CP9|ARID2_HUMAN;tr|F8WCU9|F8WCU9_HUMAN;tr|F8W108|F8W108_HUMAN",2789,"Q68CP9","ARID2_HUMAN","AT-rich interactive domain-containing protein 2 {ECO:0000305}","RID domain-containing protein 2 {ECO:0000305}","ARID2"]
["19.1923","19.9249","19.4109","19.3046",{"$nulls":3},"NAD biosynthesis via nicotinamide riboside salvage pathway;neutrophil degranulation;nicotinate nucleotide salvage;response to oxidative stress","ligase activity;nicotinate phosphoribosyltransferase activity;nicotinate-nucleotide diphosphorylase (carboxylating) activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region","Metabolic pathways;Nicotinate and nicotinamide metabolism",null,null,9,9,9,"25.5","25.5","25.5","57.578",0,"27.165",154060000,19,"0.192617",1,"0.20085","0.542618","sp|Q6XQN6|PNCB_HUMAN;tr|G5E977|G5E977_HUMAN;tr|C9J8U2|C9J8U2_HUMAN;tr|A0A087WUT5|A0A087WUT5_HUMAN","sp|Q6XQN6|PNCB_HUMAN;tr|G5E977|G5E977_HUMAN;tr|C9J8U2|C9J8U2_HUMAN",2921,"Q6XQN6","PNCB_HUMAN","Nicotinate phosphoribosyltransferase","APRTase","NAPRT"]
["17.4884","16.9113","18.0681","15.9345",{"$nulls":3},"cytoskeleton-dependent intracellular transport;microtubule-based movement;protein targeting;regulation of axonogenesis;signal transduction;T cell activation","14-3-3 protein binding;ATP binding;ATPase activity;microtubule binding;microtubule motor activity;protein kinase binding","axon;cytoplasm;cytosol;kinesin complex;microtubule;microvillus;paranode region of axon",{"$nulls":3},7,7,6,"6.5","6.5","5.8","202.79",0,"27.594",126400000,21,"0.0585148",1,"0.198589","0.179699","sp|Q9NQT8|KI13B_HUMAN;tr|E7ERX9|E7ERX9_HUMAN;tr|F2Z2F9|F2Z2F9_HUMAN;tr|H0YBA8|H0YBA8_HUMAN","sp|Q9NQT8|KI13B_HUMAN;tr|E7ERX9|E7ERX9_HUMAN",4395,"Q9NQT8","KI13B_HUMAN","Kinesin-like protein KIF13B",null,"KIF13B"]
["22.3808","22.2437","22.8576","21.3746",{"$nulls":4},"SH3 domain binding;SH3/SH2 adaptor activity","cytoplasm;extracellular exosome;extracellular space;nucleus",{"$nulls":3},4,4,4,"60.5","60.5","60.5","12.774",0,"35.436",327260000,15,"0.0878433",1,"0.196173","0.26343","sp|O75368|SH3L1_HUMAN","sp|O75368|SH3L1_HUMAN",553,"O75368","SH3L1_HUMAN","SH3 domain-binding glutamic acid-rich-like protein",null,"SH3BGRL"]
["22.6526","23.207","22.8896","22.578",{"$nulls":4},"heme binding;steroid binding;steroid hormone receptor activity","integral component of membrane;membrane;nuclear envelope",{"$nulls":3},6,6,6,"32.3","32.3","32.3","23.818",0,"51.876",539310000,40,"0.221523",1,"0.196003","0.616387","sp|O15173|PGRC2_HUMAN;tr|U3KQM0|U3KQM0_HUMAN","sp|O15173|PGRC2_HUMAN",338,"O15173","PGRC2_HUMAN","Membrane-associated progesterone receptor component 2",null,"PGRMC2"]
["20.7954","21.3136","21.1099","20.608",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport;intra-Golgi vesicle-mediated transport;retrograde vesicle-mediated transport, Golgi to ER","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi membrane;transport vesicle",{"$nulls":3},21,19,19,"34.6","32.3","32.3","97.621",0,"122.29",1085200000,76,"0.19241",1,"0.195525","0.542085","sp|Q9UBF2|COPG2_HUMAN","sp|Q9UBF2|COPG2_HUMAN",4662,"Q9UBF2","COPG2_HUMAN","Coatomer subunit gamma-2",null,"COPG2"]
["23.3878","23.6873","23.4165","23.2697",{"$nulls":3},"calcium ion transmembrane transport;endoplasmic reticulum calcium ion homeostasis;ER overload response","calcium channel activity","endoplasmic reticulum;Golgi membrane;integral component of endoplasmic reticulum membrane",{"$nulls":3},6,6,6,"30.3","30.3","30.3","21.175",0,"91.643",4121600000,127,"0.439212",1,"0.194487","1.16636","sp|Q9UM00|TMCO1_HUMAN;tr|J9JIE6|J9JIE6_HUMAN;tr|J3KS45|J3KS45_HUMAN;tr|J3QQY2|J3QQY2_HUMAN;tr|J3KTQ7|J3KTQ7_HUMAN","sp|Q9UM00|TMCO1_HUMAN;tr|J9JIE6|J9JIE6_HUMAN;tr|J3KS45|J3KS45_HUMAN;tr|J3QQY2|J3QQY2_HUMAN",4832,"Q9UM00","TMCO1_HUMAN","Calcium load-activated calcium channel {ECO:0000305|PubMed:27212239}","LAC channel {ECO:0000305|PubMed:27212239}","TMCO1"]
["18.5889","18.8212","18.8836","18.143",{"$nulls":3},"cell adhesion;neutrophil degranulation;positive regulation of substrate adhesion-dependent cell spreading;protein homooligomerization","cadherin binding;catalytic activity;protein homodimerization activity","extracellular exosome;extracellular region;extracellular space;mitochondrion;perinuclear region of cytoplasm;plasma membrane;specific granule;specific granule lumen;tertiary granule lumen",{"$nulls":3},2,2,2,"3.7","3.7","3.7","57.279","0.00025082","6.4316",73453000,5,"0.173858",1,"0.191811","0.494211","sp|Q6UX06|OLFM4_HUMAN","sp|Q6UX06|OLFM4_HUMAN",2909,"Q6UX06","OLFM4_HUMAN","Olfactomedin-4","LM4","OLFM4"]
["13.9299","14.7806","14.024","14.3039",{"$nulls":3},"cellular response to DNA damage stimulus;DNA metabolic process;DNA repair;DNA replication;DNA replication initiation;mitotic DNA replication checkpoint;mitotic G2 DNA damage checkpoint;regulation of signal transduction by p53 class mediator;response to ionizing radiation","DNA binding;identical protein binding;protein C-terminus binding","actin cytoskeleton;chromosome;condensed nuclear chromosome;cytoplasm;male germ cell nucleus;microtubule organizing center;nuclear body;nucleoplasm;nucleus;PML body;spindle pole","Homologous recombination",null,null,2,2,2,"2.3","2.3","2.3","170.68","0.0023177","3.353",27826000,7,"0.148239",1,"0.191305","0.42721","sp|Q92547|TOPB1_HUMAN","sp|Q92547|TOPB1_HUMAN",3493,"Q92547","TOPB1_HUMAN","DNA topoisomerase 2-binding protein 1",null,"TOPBP1"]
["19.6688","20.8055","20.1806","19.914",{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,"26.4","26.4","26.4","14.563",0,"13.363",106160000,15,"0.11024",1,"0.189915","0.325321","sp|Q96CP2|FWCH2_HUMAN;tr|I3L1Y9|I3L1Y9_HUMAN;tr|I3L4I0|I3L4I0_HUMAN;tr|I3L0R3|I3L0R3_HUMAN;tr|I3L231|I3L231_HUMAN;sp|Q4VC44|FWCH1_HUMAN","sp|Q96CP2|FWCH2_HUMAN;tr|I3L1Y9|I3L1Y9_HUMAN;tr|I3L4I0|I3L4I0_HUMAN",3639,"Q96CP2","FWCH2_HUMAN","FLYWCH family member 2",null,"FLYWCH2"]
["14.6785","15.0904","14.9421","14.4524",{"$nulls":3},"ion transmembrane transport","ATP binding;calcium-transporting ATPase activity;metal ion binding","Golgi membrane;integral component of membrane",{"$nulls":3},2,2,2,3,3,3,"103.19","0.00024295","5.7459",10333000,6,"0.209292",1,"0.18724","0.585277","sp|O75185|AT2C2_HUMAN;tr|A0A0A0MSP0|A0A0A0MSP0_HUMAN","sp|O75185|AT2C2_HUMAN;tr|A0A0A0MSP0|A0A0A0MSP0_HUMAN",538,"O75185","AT2C2_HUMAN","Calcium-transporting ATPase type 2C member 2","TPase 2C2","ATP2C2"]
["24.3843","24.5765","24.5577","24.0294",{"$nulls":3},"CD4-positive, alpha-beta T cell activation;cellular calcium ion homeostasis;interleukin-2 production;lipid localization;mitochondrial ATP synthesis coupled proton transport;mitochondrial calcium ion transmembrane transport;mitochondrial protein processing;mitochondrion organization;positive regulation of cardiolipin metabolic process;positive regulation of mitochondrial DNA replication;positive regulation of mitochondrial membrane potential;protein oligomerization;stress-induced mitochondrial fusion;T cell receptor signaling pathway","cardiolipin binding;GTPase binding;receptor binding","cytoskeleton;extrinsic component of plasma membrane;membrane raft;mitochondrial inner membrane;mitochondrial intermembrane space",{"$nulls":3},14,14,14,"63.8","63.8","63.8","38.534",0,"276.65",3234200000,116,"0.240646",1,"0.186835","0.664783","sp|Q9UJZ1|STML2_HUMAN;tr|A0A087WYB4|A0A087WYB4_HUMAN;tr|F2Z2I8|F2Z2I8_HUMAN","sp|Q9UJZ1|STML2_HUMAN;tr|A0A087WYB4|A0A087WYB4_HUMAN",4775,"Q9UJZ1","STML2_HUMAN","Stomatin-like protein 2, mitochondrial","LP-2","STOML2"]
["22.8688","23.4796","22.9824","22.9932",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","enzyme regulator activity","azurophil granule lumen;cytosol;extracellular exosome;extracellular region;membrane;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle;proteasome regulatory particle, base subcomplex;proteasome storage granule","Epstein-Barr virus infection;Proteasome",null,null,33,33,33,"45.2","45.2","45.2","105.84",0,"323.31",3682600000,206,"0.219081",1,"0.186397","0.610186","sp|Q99460|PSMD1_HUMAN;tr|A0A087WW66|A0A087WW66_HUMAN;tr|C9J9M4|C9J9M4_HUMAN;tr|H7BZR6|H7BZR6_HUMAN;tr|H7C378|H7C378_HUMAN;tr|F8WCE3|F8WCE3_HUMAN","sp|Q99460|PSMD1_HUMAN;tr|A0A087WW66|A0A087WW66_HUMAN",3846,"Q99460","PSMD1_HUMAN","26S proteasome non-ATPase regulatory subunit 1",null,"PSMD1"]
["20.1083","20.4221","20.3152","19.8438",{"$nulls":4},"ATP binding;protein kinase activity","cytosol",{"$nulls":3},12,12,12,"23.6","23.6","23.6","85.718",0,"31.323",364740000,42,"0.237118",1,"0.185708","0.655874","tr|E9PS17|E9PS17_HUMAN;sp|Q96KG9|NTKL_HUMAN;tr|E9PPN3|E9PPN3_HUMAN;tr|E9PK59|E9PK59_HUMAN;tr|A0A0A0MQX4|A0A0A0MQX4_HUMAN;tr|H0YDH0|H0YDH0_HUMAN;tr|H0YCI6|H0YCI6_HUMAN","tr|E9PS17|E9PS17_HUMAN;sp|Q96KG9|NTKL_HUMAN;tr|E9PPN3|E9PPN3_HUMAN;tr|E9PK59|E9PK59_HUMAN",3757,"E9PS17","E9PS17_HUMAN",null,null,"SCYL1"]
["22.388","22.2834","22.5913","21.7109",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity;protein complex binding","mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,6,6,6,39,39,39,"20.105",0,"47.347",381890000,31,"0.144161",1,"0.1846","0.416434","sp|P51970|NDUA8_HUMAN","sp|P51970|NDUA8_HUMAN",1676,"P51970","NDUA8_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8",null,"NDUFA8"]
["16.4957","16.7737","16.2725","16.6283",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;apoptotic process;cell division;cell proliferation;meiotic sister chromatid cohesion, centromeric;metaphase/anaphase transition of mitotic cell cycle;mitotic cell cycle;mitotic cell cycle checkpoint;mitotic spindle assembly checkpoint;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein localization to kinetochore;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;sister chromatid cohesion","ATP binding;protein kinase activity;protein serine/threonine kinase activity","anaphase-promoting complex;condensed chromosome kinetochore;condensed chromosome outer kinetochore;condensed nuclear chromosome kinetochore;cytoplasm;cytosol;kinetochore;microtubule organizing center;perinuclear region of cytoplasm;spindle midzone","Cell cycle;Human T-cell leukemia virus 1 infection",null,null,7,7,7,"9.3","9.3","9.3","119.54",0,"11.685",40400000,7,"0.300973",1,"0.184299","0.816353","sp|O60566|BUB1B_HUMAN;tr|H0YMK5|H0YMK5_HUMAN","sp|O60566|BUB1B_HUMAN",482,"O60566","BUB1B_HUMAN","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta",null,"BUB1B"]
["23.6392","24.1801","23.8533","23.6001",{"$nulls":3},"negative regulation of apoptotic process;negative regulation of establishment of protein localization to mitochondrion;negative regulation of JUN kinase activity;negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;negative regulation of protein ubiquitination;positive regulation of apoptotic process;protein folding;protein localization to mitochondrion;regulation of protein transport;response to heat;response to unfolded protein","ATP binding;ATPase activator activity;C3HC4-type RING finger domain binding;chaperone binding;G-protein coupled receptor binding;Hsp70 protein binding;low-density lipoprotein particle receptor binding;metal ion binding;Tat protein binding;ubiquitin protein ligase binding;unfolded protein binding","cytoplasmic side of endoplasmic reticulum membrane;cytosol;extracellular exosome;membrane;microtubule cytoskeleton;mitochondrion;nucleus;perinuclear region of cytoplasm","Protein processing in endoplasmic reticulum",null,null,16,16,16,"46.3","46.3","46.3","44.868",0,"167.79",5538500000,276,"0.220049",1,"0.182938","0.612644","sp|P31689|DNJA1_HUMAN","sp|P31689|DNJA1_HUMAN",1333,"P31689","DNJA1_HUMAN","DnaJ homolog subfamily A member 1",null,"DNAJA1"]
["18.6963","19.1599","19.0962","18.3962",{"$nulls":3},"centrosome duplication;cytoplasmic microtubule organization;interphase microtubule nucleation by interphase microtubule organizing center;meiotic cell cycle;microtubule nucleation;mitotic spindle assembly;protein complex assembly","gamma-tubulin binding;structural constituent of cytoskeleton","centrosome;cytoplasmic microtubule;cytosol;equatorial microtubule organizing center;gamma-tubulin small complex;membrane;microtubule organizing center;nucleoplasm;spindle pole",{"$nulls":3},11,11,11,"16.4","16.4","16.4","102.53",0,"30.336",283460000,36,"0.150521",1,"0.18186","0.433228","sp|Q9BSJ2|GCP2_HUMAN;tr|F2Z2B9|F2Z2B9_HUMAN;tr|B3KTU7|B3KTU7_HUMAN","sp|Q9BSJ2|GCP2_HUMAN;tr|F2Z2B9|F2Z2B9_HUMAN",3950,"Q9BSJ2","GCP2_HUMAN","Gamma-tubulin complex component 2","CP-2;GCP2","TUBGCP2"]
["23.5443","22.8991","23.6177","22.4646",{"$nulls":3},"cardiolipin acyl-chain remodeling;fatty acid beta-oxidation","3-hydroxyacyl-CoA dehydrogenase activity;acetyl-CoA C-acyltransferase activity;enoyl-CoA hydratase activity;long-chain-3-hydroxyacyl-CoA dehydrogenase activity;RNA binding","endoplasmic reticulum;extracellular exosome;mitochondrial envelope;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrial outer membrane;mitochondrion","Fatty acid degradation;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,23,23,23,"54.2","54.2","54.2","51.294",0,"323.31",8077400000,349,"0.0913535",1,"0.180523","0.273236","sp|P55084|ECHB_HUMAN;tr|F5GZQ3|F5GZQ3_HUMAN;tr|B5MD38|B5MD38_HUMAN;tr|C9JEY0|C9JEY0_HUMAN;tr|C9JE81|C9JE81_HUMAN;tr|C9K0M0|C9K0M0_HUMAN","sp|P55084|ECHB_HUMAN;tr|F5GZQ3|F5GZQ3_HUMAN;tr|B5MD38|B5MD38_HUMAN",1755,"P55084","ECHB_HUMAN","Trifunctional enzyme subunit beta, mitochondrial",null,"HADHB"]
["27.389","27.2877","27.5824","26.7353",{"$nulls":3},"angiogenesis;body fluid secretion;catabolism by host of symbiont protein;collagen fibril organization;fibrinolysis;interleukin-12-mediated signaling pathway;membrane raft assembly;negative regulation by host of symbiont molecular function;negative regulation of development of symbiont involved in interaction with host;negative regulation of low-density lipoprotein particle receptor catabolic process;neutrophil degranulation;osteoclast development;positive regulation of fibroblast proliferation;positive regulation of low-density lipoprotein particle clearance;positive regulation of low-density lipoprotein particle receptor binding;positive regulation of low-density lipoprotein receptor activity;positive regulation of protein phosphorylation;positive regulation of receptor recycling;positive regulation of receptor-mediated endocytosis involved in cholesterol transport;positive regulation of vacuole organization;positive regulation of vesicle fusion;protein heterotetramerization;protein localization to plasma membrane;response to thyroid hormone;vesicle budding from membrane","bone sialoprotein binding;cadherin binding involved in cell-cell adhesion;calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;cytoskeletal protein binding;identical protein binding;molecular function regulator;phosphatidylinositol-4,5-bisphosphate binding;phospholipase A2 inhibitor activity;protease binding;Rab GTPase binding;RNA binding;S100 protein binding","azurophil granule lumen;basement membrane;basolateral plasma membrane;cell cortex;cell surface;cell-cell adherens junction;cytoplasm;cytosol;early endosome;endosome;extracellular exosome;extracellular matrix;extracellular region;extracellular space;extrinsic component of plasma membrane;late endosome membrane;lipid droplet;lysosomal membrane;macropinosome;melanosome;membrane;membrane raft;midbody;myelin sheath adaxonal region;nucleus;PCSK9-AnxA2 complex;perinuclear region of cytoplasm;plasma membrane;ruffle;sarcolemma;Schmidt-Lanterman incisure;vesicle",{"$nulls":3},29,29,29,"73.2","73.2","73.2","38.604",0,"323.31",31952000000,596,"0.14579",1,"0.179473","0.420744","sp|P07355|ANXA2_HUMAN;tr|H0YN42|H0YN42_HUMAN;tr|H0YMD0|H0YMD0_HUMAN;tr|H0YMU9|H0YMU9_HUMAN;tr|H0YM50|H0YM50_HUMAN;sp|A6NMY6|AXA2L_HUMAN;tr|H0YNP5|H0YNP5_HUMAN;tr|H0YN28|H0YN28_HUMAN;tr|H0YL33|H0YL33_HUMAN;tr|H0YKS4|H0YKS4_HUMAN;tr|H0YMM1|H0YMM1_HUMAN;tr|H0YKZ7|H0YKZ7_HUMAN;tr|H0YLV6|H0YLV6_HUMAN;tr|H0YMT9|H0YMT9_HUMAN;tr|H0YKX9|H0YKX9_HUMAN;tr|H0YKL9|H0YKL9_HUMAN;tr|H0YMW4|H0YMW4_HUMAN;tr|H0YNA0|H0YNA0_HUMAN;tr|H0YKV8|H0YKV8_HUMAN;tr|H0YMD9|H0YMD9_HUMAN;tr|H0YNB8|H0YNB8_HUMAN;tr|H0YN52|H0YN52_HUMAN;tr|H0YKN4|H0YKN4_HUMAN;tr|H0YLE2|H0YLE2_HUMAN","sp|P07355|ANXA2_HUMAN;tr|H0YN42|H0YN42_HUMAN;tr|H0YMD0|H0YMD0_HUMAN;tr|H0YMU9|H0YMU9_HUMAN;tr|H0YM50|H0YM50_HUMAN;sp|A6NMY6|AXA2L_HUMAN;tr|H0YNP5|H0YNP5_HUMAN;tr|H0YN28|H0YN28_HUMAN;tr|H0YL33|H0YL33_HUMAN",897,"P07355","ANXA2_HUMAN","Annexin A2",null,"ANXA2"]
["15.1005","17.7592","16.9249","15.5759",{"$nulls":3},"tRNA pseudouridine synthesis","pseudouridine synthase activity;RNA binding","mitochondrial matrix;mitochondrion",{"$nulls":3},9,9,9,"28.4","28.4","28.4","42.205",0,"44.503",358480000,55,"0.0384963",1,"0.179471","0.120396","sp|Q96CM3|RUSD4_HUMAN;tr|E9PJV3|E9PJV3_HUMAN","sp|Q96CM3|RUSD4_HUMAN",3634,"Q96CM3","RUSD4_HUMAN","Mitochondrial RNA pseudouridine synthase RPUSD4",null,"RPUSD4"]
["24.6054","24.6689","24.6831","24.2362",{"$nulls":3},"actin cytoskeleton organization;actin cytoskeleton reorganization;alpha-beta T cell lineage commitment;androgen receptor signaling pathway;angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure;apical junction assembly;apolipoprotein A-I-mediated signaling pathway;beta selection;cell junction assembly;cell migration;cell-matrix adhesion;cellular response to chemokine;cellular response to lipopolysaccharide;cerebral cortex cell migration;cleavage furrow formation;endothelial cell migration;endothelial tube lumen extension;ephrin receptor signaling pathway;establishment of epithelial cell apical/basal polarity;forebrain radial glial cell differentiation;G-protein coupled receptor signaling pathway;GTP metabolic process;mitotic cleavage furrow formation;mitotic spindle assembly;negative chemotaxis;negative regulation of axonogenesis;negative regulation of cell migration involved in sprouting angiogenesis;negative regulation of cell size;negative regulation of cell-substrate adhesion;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of intracellular steroid hormone receptor signaling pathway;negative regulation of neuron apoptotic process;negative regulation of oxidative phosphorylation;negative regulation of reactive oxygen species biosynthetic process;neuron projection morphogenesis;neutrophil degranulation;odontogenesis;ossification involved in bone maturation;phosphatidylinositol-mediated signaling;platelet activation;positive regulation of actin filament polymerization;positive regulation of alpha-beta T cell differentiation;positive regulation of axonogenesis;positive regulation of cell growth;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cytokinesis;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of lipase activity;positive regulation of neuron apoptotic process;positive regulation of neuron differentiation;positive regulation of NF-kappaB import into nucleus;positive regulation of podosome assembly;positive regulation of protein serine/threonine kinase activity;positive regulation of stress fiber assembly;positive regulation of T cell migration;positive regulation of translation;positive regulation of vascular smooth muscle contraction;protein deubiquitination;regulation of actin cytoskeleton organization;regulation of calcium ion transport;regulation of cell migration;regulation of cell motility;regulation of dendrite development;regulation of focal adhesion assembly;regulation of microtubule cytoskeleton organization;regulation of modification of synaptic structure;regulation of neural precursor cell proliferation;regulation of osteoblast proliferation;regulation of small GTPase mediated signal transduction;regulation of systemic arterial blood pressure by endothelin;regulation of transcription from RNA polymerase II promoter;response to amino acid;response to drug;response to ethanol;response to glucocorticoid;response to glucose;response to hypoxia;response to mechanical stimulus;Rho protein signal transduction;Roundabout signaling pathway;skeletal muscle satellite cell migration;skeletal muscle tissue development;stress fiber assembly;stress-activated protein kinase signaling cascade;substantia nigra development;trabecula morphogenesis;transforming growth factor beta receptor signaling pathway;vascular endothelial growth factor receptor signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway;wound healing, spreading of cells","GDP binding;GTP binding;GTPase activity;myosin binding;protein domain specific binding;Rho GDP-dissociation inhibitor binding","apical junction complex;axon;cell cortex;cell junction;cell periphery;cleavage furrow;cytoskeleton;cytosol;dendritic spine;endoplasmic reticulum membrane;endosome;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane;ficolin-1-rich granule membrane;focal adhesion;lamellipodium;midbody;mitochondrion;nucleus;plasma membrane;ruffle membrane;secretory granule membrane;vesicle","Adherens junction;Axon guidance;Bacterial invasion of epithelial cells;cAMP signaling pathway;cGMP-PKG signaling pathway;Chemokine signaling pathway;Colorectal cancer;C-type lectin receptor signaling pathway;Endocytosis;Fluid shear stress and atherosclerosis;Focal adhesion;Human cytomegalovirus infection;Leukocyte transendothelial migration;MicroRNAs in cancer;mTOR signaling pathway;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Oxytocin signaling pathway;Pancreatic secretion;Parathyroid hormone synthesis, secretion and action;Pathogenic Escherichia coli infection;Pathways in cancer;Pertussis;Phospholipase D signaling pathway;Platelet activation;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Sphingolipid signaling pathway;T cell receptor signaling pathway;TGF-beta signaling pathway;Tight junction;Tuberculosis;Vascular smooth muscle contraction;Viral carcinogenesis;Wnt signaling pathway;Yersinia infection",null,null,10,10,4,"52.8","52.8","30.1","21.768",0,"99.311",1674900000,78,"0.288957",1,"0.177458","0.78623","sp|P61586|RHOA_HUMAN;tr|C9JNR4|C9JNR4_HUMAN;tr|C9JX21|C9JX21_HUMAN;tr|C9JRM1|C9JRM1_HUMAN","sp|P61586|RHOA_HUMAN;tr|C9JNR4|C9JNR4_HUMAN;tr|C9JX21|C9JX21_HUMAN",1849,"P61586","RHOA_HUMAN","Transforming protein RhoA",null,"RHOA"]
["23.1103","23.1562","23.4305","22.4857",{"$nulls":3},"IRES-dependent viral translational initiation;regulation of translational initiation;translational initiation;viral translational termination-reinitiation","protein complex scaffold activity;RNA binding;translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;extracellular exosome","RNA transport",null,null,30,30,30,"52.6","52.6","52.6","92.48",0,"164.25",2983300000,164,"0.126921",1,"0.175213","0.370476","sp|P55884|EIF3B_HUMAN;tr|C9JZG1|C9JZG1_HUMAN;tr|C9JQN7|C9JQN7_HUMAN","sp|P55884|EIF3B_HUMAN",1773,"P55884","EIF3B_HUMAN","Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001}","IF3b {ECO:0000255|HAMAP-Rule:MF_03001}","EIF3B"]
["19.9265","19.4515","20.1814","18.8477",{"$nulls":3},"determination of left/right symmetry;protein glycosylation;protein N-linked glycosylation;protein N-linked glycosylation via asparagine","dolichyl-phosphate beta-glucosyltransferase activity;oligosaccharyl transferase activity","endoplasmic reticulum membrane;integral component of membrane;membrane","Metabolic pathways;N-Glycan biosynthesis",null,null,3,3,3,"12.3","12.3","12.3","36.946",0,"11.909",137250000,13,"0.0817813",1,"0.174419","0.246393","sp|Q9Y673|ALG5_HUMAN","sp|Q9Y673|ALG5_HUMAN",5077,"Q9Y673","ALG5_HUMAN","Dolichyl-phosphate beta-glucosyltransferase","olP-glucosyltransferase","ALG5"]
["18.1752","19.4468","18.4679","18.806",{"$nulls":9},17,15,15,"17.6","15.5","15.5","148.13",0,"56.881",326660000,50,"0.0882349",1,"0.174025","0.264526","tr|J3KP58|J3KP58_HUMAN;sp|P30622|CLIP1_HUMAN;tr|F5H6A0|F5H6A0_HUMAN;tr|F5H0N7|F5H0N7_HUMAN;tr|F6VGP8|F6VGP8_HUMAN;tr|F5H1T5|F5H1T5_HUMAN;tr|F5H367|F5H367_HUMAN;tr|F5H270|F5H270_HUMAN","tr|J3KP58|J3KP58_HUMAN;sp|P30622|CLIP1_HUMAN;tr|F5H6A0|F5H6A0_HUMAN;tr|F5H0N7|F5H0N7_HUMAN",5276,"J3KP58","J3KP58_HUMAN",null,null,"CLIP1"]
["19.9398","20.1453","19.6297","20.1106",{"$nulls":3},"B cell differentiation;B cell mediated immunity;cell cycle arrest;determination of adult lifespan;DNA repair;double-strand break repair;germ cell development;in utero embryonic development;intra-S DNA damage checkpoint;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;isotype switching;maintenance of DNA repeat elements;male gonad development;meiotic gene conversion;mismatch repair;negative regulation of DNA recombination;negative regulation of neuron apoptotic process;negative regulation of reciprocal meiotic recombination;oxidative phosphorylation;positive regulation of helicase activity;positive regulation of isotype switching to IgA isotypes;positive regulation of isotype switching to IgG isotypes;postreplication repair;response to UV-B;response to X-ray;somatic hypermutation of immunoglobulin genes;somatic recombination of immunoglobulin gene segments","ATP binding;centromeric DNA binding;damaged DNA binding;DNA binding;DNA-dependent ATPase activity;double-strand/single-strand DNA junction binding;enzyme binding;guanine/thymine mispair binding;heteroduplex DNA loop binding;protein C-terminus binding;protein homodimerization activity;protein kinase binding;Y-form DNA binding","membrane;MutSalpha complex;MutSbeta complex;nuclear chromosome, telomeric region;nucleoplasm","Colorectal cancer;Mismatch repair;Pathways in cancer;Platinum drug resistance",null,null,19,19,17,"22.1","22.1","19.8","104.74",0,"41.052",531230000,52,"0.238507",1,"0.172427","0.659383","sp|P43246|MSH2_HUMAN;tr|V9H019|V9H019_HUMAN;tr|E9PHA6|E9PHA6_HUMAN;tr|A0A087X078|A0A087X078_HUMAN;tr|A0A087X1E7|A0A087X1E7_HUMAN;tr|V9H0B2|V9H0B2_HUMAN;tr|V9H015|V9H015_HUMAN","sp|P43246|MSH2_HUMAN;tr|V9H019|V9H019_HUMAN;tr|E9PHA6|E9PHA6_HUMAN;tr|A0A087X078|A0A087X078_HUMAN;tr|A0A087X1E7|A0A087X1E7_HUMAN",1487,"P43246","MSH2_HUMAN","DNA mismatch repair protein Msh2","MSH2","MSH2"]
["16.6457","17.8091","16.8277","17.2836",{"$nulls":3},"mRNA processing;regulation of alternative mRNA splicing, via spliceosome;regulation of apoptotic process;RNA splicing","identical protein binding;metal ion binding;miRNA binding;protein complex binding;RNA binding","nuclear speck;nucleus",{"$nulls":3},6,6,6,"10.6","10.6","10.6","103.53",0,"14.922",117640000,18,"0.0919156",1,"0.171687","0.274802","sp|P98175|RBM10_HUMAN;tr|A0A0A0MR66|A0A0A0MR66_HUMAN","sp|P98175|RBM10_HUMAN;tr|A0A0A0MR66|A0A0A0MR66_HUMAN",2022,"P98175","RBM10_HUMAN","RNA-binding protein 10 {ECO:0000305}",null,"RBM10"]
["24.0728","23.9444","23.9612","23.7129",{"$nulls":3},"translational initiation","RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytosol",{"$nulls":3},5,5,5,"48.6","48.6","48.6","16.46",0,"21.521",859280000,30,"0.462804",1,"0.171557","1.2275","sp|P47813|IF1AX_HUMAN;sp|O14602|IF1AY_HUMAN;tr|A6NJH9|A6NJH9_HUMAN;tr|X6RAC9|X6RAC9_HUMAN","sp|P47813|IF1AX_HUMAN;sp|O14602|IF1AY_HUMAN;tr|A6NJH9|A6NJH9_HUMAN;tr|X6RAC9|X6RAC9_HUMAN",264,"P47813","IF1AX_HUMAN","Eukaryotic translation initiation factor 1A, X-chromosomal","IF-1A X isoform","EIF1AX"]
["23.5247","23.9534","23.8109","23.3261",{"$nulls":3},"cell division;cell proliferation;multicellular organism development;protein folding;sister chromatid cohesion","cadherin binding;unfolded protein binding","cytoplasm;cytosol;microtubule;nucleoplasm",{"$nulls":3},15,15,15,"45.6","45.6","45.6","38.242",0,"102.66",2587700000,115,"0.186582",1,"0.170561","0.527095","sp|Q9Y266|NUDC_HUMAN;tr|A0A0A0MSU9|A0A0A0MSU9_HUMAN;tr|A0A0A0MSS4|A0A0A0MSS4_HUMAN","sp|Q9Y266|NUDC_HUMAN;tr|A0A0A0MSU9|A0A0A0MSU9_HUMAN;tr|A0A0A0MSS4|A0A0A0MSS4_HUMAN",4898,"Q9Y266","NUDC_HUMAN","Nuclear migration protein nudC",null,"NUDC"]
["20.1019","20.5484","20.3322","19.9773",{"$nulls":3},"mRNA splicing, via spliceosome;protein localization;regulation of apoptotic process;RNA secondary structure unwinding","ATP binding;ATP-dependent RNA helicase activity;RNA binding","Cajal body;cytoplasm;cytosol;membrane;nuclear speck;nucleolus;nucleoplasm;nucleus","Spliceosome",null,null,15,15,15,27,27,27,"102.97",0,"77.156",467650000,45,"0.214062",1,"0.170384","0.597426","sp|Q86XP3|DDX42_HUMAN;tr|A0A0A0MSJ0|A0A0A0MSJ0_HUMAN;tr|J3KRE3|J3KRE3_HUMAN;tr|J3QRI2|J3QRI2_HUMAN;tr|J3KTK9|J3KTK9_HUMAN","sp|Q86XP3|DDX42_HUMAN;tr|A0A0A0MSJ0|A0A0A0MSJ0_HUMAN",3085,"Q86XP3","DDX42_HUMAN","ATP-dependent RNA helicase DDX42",null,"DDX42"]
["18.5695","19.4246","19.6685","17.9858",{"$nulls":3},"cell division;cellular response to organic cyclic compound;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;regulation of mitotic spindle organization;RNA export from nucleus;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;tRNA export from nucleus;viral process;viral transcription","microtubule binding;RNA binding;ubiquitin binding","cytoplasm;fibrillar center;host cell;mitotic spindle pole;nuclear envelope;nuclear pore;nucleus","Influenza A;RNA transport",null,null,4,4,4,"13.3","13.3","13.3","40.968","0.00025667","6.9442",72939000,7,"0.0586118",1,"0.169861","0.179982","sp|P78406|RAE1L_HUMAN;tr|E9PQ57|E9PQ57_HUMAN;tr|E9PPG9|E9PPG9_HUMAN;tr|B0QZ36|B0QZ36_HUMAN","sp|P78406|RAE1L_HUMAN;tr|E9PQ57|E9PQ57_HUMAN;tr|E9PPG9|E9PPG9_HUMAN",1978,"P78406","RAE1L_HUMAN","mRNA export factor",null,"RAE1"]
["21.7651","21.7675","22.063","21.1324",{"$nulls":3},"cell growth involved in cardiac muscle cell development;regulation of dendritic spine morphogenesis;regulation of synapse assembly","actin binding;actinin binding;cadherin binding involved in cell-cell adhesion;metal ion binding;protein kinase C binding;protein N-terminus binding","actin cytoskeleton;cell-cell adherens junction;cytosol;membrane;neuron projection;postsynaptic density;postsynaptic membrane",{"$nulls":3},14,14,14,32,32,32,"63.944",0,"72.722",864700000,78,"0.123887",1,"0.168589","0.362319","sp|Q96HC4|PDLI5_HUMAN;tr|A0A0D9SFR4|A0A0D9SFR4_HUMAN;tr|H0Y8Y3|H0Y8Y3_HUMAN;tr|H0YBI4|H0YBI4_HUMAN;tr|H0Y929|H0Y929_HUMAN;tr|A0A0A0MSP3|A0A0A0MSP3_HUMAN;tr|D6RAA1|D6RAA1_HUMAN;tr|A0A0D9SFW3|A0A0D9SFW3_HUMAN;tr|D6RGG6|D6RGG6_HUMAN","sp|Q96HC4|PDLI5_HUMAN",3715,"Q96HC4","PDLI5_HUMAN","PDZ and LIM domain protein 5",null,"PDLIM5"]
["21.8476","21.6407","21.9528","21.1994",{"$nulls":3},"negative regulation of endoribonuclease activity;regulation of type I interferon-mediated signaling pathway;ribosomal subunit export from nucleus;translational initiation;translational termination;viral process","ATP binding;ATPase activity;endoribonuclease inhibitor activity;iron ion binding;ribosomal small subunit binding","cytoplasm;cytosol;membrane;mitochondrial matrix;mitochondrion",{"$nulls":3},16,16,16,"32.2","32.2","32.2","67.314",0,"284.31",873480000,71,"0.149397",1,"0.168072","0.430267","sp|P61221|ABCE1_HUMAN;tr|D6R9I9|D6R9I9_HUMAN;tr|D6RGF4|D6RGF4_HUMAN;tr|H0Y990|H0Y990_HUMAN","sp|P61221|ABCE1_HUMAN;tr|D6R9I9|D6R9I9_HUMAN;tr|D6RGF4|D6RGF4_HUMAN",1837,"P61221","ABCE1_HUMAN","ATP-binding cassette sub-family E member 1",null,"ABCE1"]
["21.3656","20.7459","21.3403","20.4383",{"$nulls":3},"activation of phospholipase D activity;Golgi organization;Golgi vesicle transport;protein localization to Golgi apparatus;retrograde transport, endosome to Golgi;small GTPase mediated signal transduction;toxin metabolic process","enzyme activator activity;GTP binding;GTPase activity;metal ion binding;protein domain specific binding","cytoplasm;cytosol;extracellular exosome;Golgi apparatus;trans-Golgi network;trans-Golgi network membrane",{"$nulls":3},4,4,4,"27.6","27.6","27.6","20.417",0,"31.073",263380000,33,"0.102551",1,"0.166479","0.304249","sp|P40616|ARL1_HUMAN;tr|B4DZG7|B4DZG7_HUMAN;tr|F8VYN9|F8VYN9_HUMAN;tr|F8VP99|F8VP99_HUMAN;tr|F8W1Z8|F8W1Z8_HUMAN;tr|F8VP63|F8VP63_HUMAN","sp|P40616|ARL1_HUMAN;tr|B4DZG7|B4DZG7_HUMAN;tr|F8VYN9|F8VYN9_HUMAN",1440,"P40616","ARL1_HUMAN","ADP-ribosylation factor-like protein 1",null,"ARL1"]
["19.4366","19.894","19.8039","19.1951",{"$nulls":9},2,2,2,"9.6","9.6","9.6","25.129","0.00025368","6.6646",90316000,6,"0.151419",1,"0.165838","0.435592","tr|A6PWM2|A6PWM2_HUMAN;sp|Q6UXH1|CREL2_HUMAN","tr|A6PWM2|A6PWM2_HUMAN;sp|Q6UXH1|CREL2_HUMAN",2912,"A6PWM2","A6PWM2_HUMAN",null,null,"CRELD2"]
["17.5504","17.1754","17.7761","16.6183",{"$nulls":9},2,2,2,"27.9","27.9","27.9","16.549","0.00026738","7.7645",30728000,5,"0.0910294",1,"0.165717","0.272332","tr|J3QKK8|J3QKK8_HUMAN;tr|A0A0A0MRV4|A0A0A0MRV4_HUMAN;tr|J3KRV9|J3KRV9_HUMAN;sp|Q8TBF2|PGFS_HUMAN;tr|J3KPF6|J3KPF6_HUMAN;tr|J3KPF5|J3KPF5_HUMAN;tr|A0A0A0MT35|A0A0A0MT35_HUMAN","tr|J3QKK8|J3QKK8_HUMAN;tr|A0A0A0MRV4|A0A0A0MRV4_HUMAN;tr|J3KRV9|J3KRV9_HUMAN;sp|Q8TBF2|PGFS_HUMAN;tr|J3KPF6|J3KPF6_HUMAN;tr|J3KPF5|J3KPF5_HUMAN;tr|A0A0A0MT35|A0A0A0MT35_HUMAN",3367,"J3QKK8","J3QKK8_HUMAN",null,null,"FAM213B"]
["25.5398","25.529","25.6024","25.1368",{"$nulls":3},"activation of innate immune response;brain development;cellular hyperosmotic salinity response;cellular response to gamma radiation;cellular response to X-ray;DNA ligation;DNA recombination;double-strand break repair via classical nonhomologous end joining;double-strand break repair via nonhomologous end joining;establishment of integrated proviral latency;innate immune response;negative regulation of transcription, DNA-templated;neutrophil degranulation;positive regulation of protein kinase activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;protein heterotetramerization;regulation of smooth muscle cell proliferation;telomere maintenance;transcription, DNA-templated","5'-deoxyribose-5-phosphate lyase activity;ATP binding;ATP-dependent DNA helicase activity;cyclin binding;damaged DNA binding;DNA binding;double-stranded DNA binding;macromolecular complex binding;protein C-terminus binding;RNA binding;telomeric DNA binding;transcription regulatory region DNA binding","cytosol;extracellular region;ficolin-1-rich granule lumen;Ku70:Ku80 complex;membrane;nonhomologous end joining complex;nuclear chromosome, telomeric region;nuclear telomere cap complex;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;secretory granule lumen;transcription factor complex","Non-homologous end-joining",null,null,34,34,34,54,54,54,"69.842",0,"323.31",14917000000,651,"0.257716",1,"0.164824","0.707796","sp|P12956|XRCC6_HUMAN;tr|B1AHC9|B1AHC9_HUMAN","sp|P12956|XRCC6_HUMAN;tr|B1AHC9|B1AHC9_HUMAN",1019,"P12956","XRCC6_HUMAN","X-ray repair cross-complementing protein 6",null,"XRCC6"]
["22.8624","23.0681","23.0114","22.5898",{"$nulls":3},"positive regulation of mRNA binding;positive regulation of translation;translational initiation","RNA binding;translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex","RNA transport",null,null,24,24,24,"35.8","35.8","35.8","105.34",0,"297.54",2879100000,148,"0.255392",1,"0.16465","0.701947","sp|Q99613|EIF3C_HUMAN;sp|B5ME19|EIFCL_HUMAN;tr|H3BPE4|H3BPE4_HUMAN;tr|H3BPE3|H3BPE3_HUMAN;tr|H3BTY8|H3BTY8_HUMAN","sp|Q99613|EIF3C_HUMAN;sp|B5ME19|EIFCL_HUMAN",3865,"Q99613","EIF3C_HUMAN","Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}","IF3c {ECO:0000255|HAMAP-Rule:MF_03002}","EIF3C"]
["17.9893","18.0991","18.608","17.1523",{"$nulls":3},"cellular respiration;heme a biosynthetic process;heme biosynthetic process;hydrogen ion transmembrane transport;mitochondrial electron transport, cytochrome c to oxygen;oxidation-reduction process;respiratory chain complex IV assembly;respiratory gaseous exchange","cytochrome-c oxidase activity;oxidoreductase activity, acting on the CH-CH group of donors","cytochrome complex;integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrion;nucleus","Metabolic pathways;Oxidative phosphorylation;Porphyrin and chlorophyll metabolism;Thermogenesis",null,null,4,4,4,"12.4","12.4","12.4","46.03","0.00026323","7.4508",79856000,12,"0.0741578",1,"0.164062","0.224778","sp|Q7KZN9|COX15_HUMAN","sp|Q7KZN9|COX15_HUMAN",2958,"Q7KZN9","COX15_HUMAN","Cytochrome c oxidase assembly protein COX15 homolog",null,"COX15"]
["16.9887",1,"16.6616",1,{"$nulls":3},"anterior/posterior axis specification;gastrulation with mouth forming second;germ cell development;histone H2A monoubiquitination;histone H2A-K119 monoubiquitination;mitotic cell cycle;negative regulation of DNA binding transcription factor activity;negative regulation of G0 to G1 transition;negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","chromatin binding;RING-like zinc finger domain binding;ubiquitin protein ligase activity;zinc ion binding","euchromatin;MLL1 complex;nuclear body;nucleoplasm;nucleus;PcG protein complex;PRC1 complex;sex chromatin;ubiquitin ligase complex",{"$nulls":3},4,4,3,"16.1","16.1","11.9","37.655",0,"11.253",49051000,6,"0.00451078",1,"0.163534","0.0146134","sp|Q99496|RING2_HUMAN;tr|X6RFN3|X6RFN3_HUMAN","sp|Q99496|RING2_HUMAN;tr|X6RFN3|X6RFN3_HUMAN",3848,"Q99496","RING2_HUMAN","E3 ubiquitin-protein ligase RING2",null,"RNF2"]
["21.2254","21.2023","20.9025","21.1989",{"$nulls":3},"apoptotic DNA fragmentation;chaperone-mediated protein folding;negative regulation of apoptotic DNA fragmentation;negative regulation of deoxyribonuclease activity;negative regulation of execution phase of apoptosis;positive regulation of apoptotic process;thymocyte apoptotic process","deoxyribonuclease inhibitor activity;protein binding involved in protein folding;protein domain specific binding","cytosol;nuclear chromatin;nucleoplasm;nucleus;plasma membrane","Apoptosis",null,null,8,8,8,"31.1","31.1","31.1","36.521",0,"35.176",344160000,24,"0.412318",1,"0.163133","1.09732","sp|O00273|DFFA_HUMAN;tr|K7ERT1|K7ERT1_HUMAN","sp|O00273|DFFA_HUMAN",210,"O00273","DFFA_HUMAN","DNA fragmentation factor subunit alpha",null,"DFFA"]
["21.2504","21.3628","21.1694","21.123",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","cytosol;mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome;mitochondrion","Ribosome",null,null,6,6,6,"35.9","35.9","35.9","30.156",0,"43.168",283420000,14,"0.92534",1,"0.160377","2.63669","sp|Q13084|RM28_HUMAN;tr|A2IDC6|A2IDC6_HUMAN;tr|Q4TT37|Q4TT37_HUMAN;tr|A2IDC7|A2IDC7_HUMAN","sp|Q13084|RM28_HUMAN;tr|A2IDC6|A2IDC6_HUMAN;tr|Q4TT37|Q4TT37_HUMAN;tr|A2IDC7|A2IDC7_HUMAN",2200,"Q13084","RM28_HUMAN","39S ribosomal protein L28, mitochondrial","28mt;RP-L28","MRPL28"]
["17.8454","19.1097","17.6257","19.0093",{"$nulls":3},"axon guidance;cell adhesion;iron ion homeostasis;positive regulation of BMP signaling pathway","co-receptor binding;receptor activity","Golgi apparatus;integral component of plasma membrane;nucleoplasm;plasma membrane;plasma membrane protein complex","Axon guidance;Cell adhesion molecules (CAMs);TGF-beta signaling pathway",null,null,21,21,21,"20.9","20.9","20.9","160.01",0,"72.133",642040000,82,"0.0554431",1,"0.159989","0.170723","sp|Q92859|NEO1_HUMAN;tr|Q59FP8|Q59FP8_HUMAN","sp|Q92859|NEO1_HUMAN;tr|Q59FP8|Q59FP8_HUMAN",3542,"Q92859","NEO1_HUMAN","Neogenin",null,"NEO1"]
["18.4227","18.5422","18.5294","18.1201",{"$nulls":3},"adipose tissue development;cellular response to cholesterol;cellular response to glucose stimulus;cellular response to testosterone stimulus;fatty acid metabolic process;ketone body biosynthetic process;liver development;positive regulation of insulin secretion;response to drug;response to ethanol;response to nutrient;response to oleic acid;response to purine-containing compound;response to starvation;white fat cell differentiation","acetoacetate-CoA ligase activity;ATP binding;butyrate-CoA ligase activity","cytosol","Butanoate metabolism;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,3,3,3,"5.7","5.7","5.7","75.143",0,"8.442",88022000,7,"0.270378",1,"0.157681","0.739615","sp|Q86V21|AACS_HUMAN;tr|E7EW25|E7EW25_HUMAN","sp|Q86V21|AACS_HUMAN",3055,"Q86V21","AACS_HUMAN","Acetoacetyl-CoA synthetase",null,"AACS"]
["19.5998","19.5616","19.6879","19.1588",{"$nulls":3},"negative regulation of DNA recombination at telomere;negative regulation of protein phosphorylation;negative regulation of telomere maintenance;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of NIK/NF-kappaB signaling;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein acetylation;protection from non-homologous end joining at telomere;protein localization to chromosome, telomeric region;regulation of double-strand break repair via homologous recombination;regulation of telomere maintenance;regulation of transcription, DNA-templated;telomere capping;telomere maintenance;telomere maintenance via telomerase;telomere maintenance via telomere lengthening;transcription, DNA-templated","G-rich strand telomeric DNA binding;phosphatase binding;telomeric DNA binding","chromosome, telomeric region;cytoplasm;cytosol;nuclear body;nuclear chromosome;nuclear chromosome, telomeric region;nuclear envelope;nuclear telomere cap complex;nucleoplasm;nucleus;shelterin complex",{"$nulls":3},7,7,7,"20.1","20.1","20.1","44.259",0,"26.087",126930000,21,"0.212347",1,"0.157312","0.59306","sp|Q9NYB0|TE2IP_HUMAN","sp|Q9NYB0|TE2IP_HUMAN",4563,"Q9NYB0","TE2IP_HUMAN","Telomeric repeat-binding factor 2-interacting protein 1","ERF2-interacting telomeric protein 1;RF2-interacting telomeric protein 1","TERF2IP"]
["22.3778","23.1945","22.5263","22.7332",{"$nulls":3},"cell cycle arrest;peptidyl-threonine dephosphorylation;protein dephosphorylation","metal ion binding;protein serine/threonine phosphatase activity","cytoplasm;membrane;nucleoplasm;nucleus",{"$nulls":3},18,18,18,48,48,48,"59.271",0,"197.11",1364100000,98,"0.127242",1,"0.156424","0.371339","sp|O15355|PPM1G_HUMAN","sp|O15355|PPM1G_HUMAN",354,"O15355","PPM1G_HUMAN","Protein phosphatase 1G",null,"PPM1G"]
["21.5643","21.6984","21.6103","21.3438",{"$nulls":3},"deoxyribose phosphate catabolic process;galactose catabolic process;glucose metabolic process;glycogen biosynthetic process;glycogen catabolic process;neutrophil degranulation;pentose-phosphate shunt","magnesium ion binding;phosphoglucomutase activity;phosphopentomutase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;secretory granule lumen","Amino sugar and nucleotide sugar metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways;Pentose phosphate pathway;Purine metabolism;Starch and sucrose metabolism",null,null,21,21,21,"36.8","36.8","36.8","68.283",0,"84.494",920600000,80,"0.387692",1,"0.154321","1.03463","sp|Q96G03|PGM2_HUMAN;tr|E7ENQ8|E7ENQ8_HUMAN;tr|E9PD70|E9PD70_HUMAN;tr|H0Y921|H0Y921_HUMAN","sp|Q96G03|PGM2_HUMAN",3690,"Q96G03","PGM2_HUMAN","Phosphoglucomutase-2","GM 2","PGM2"]
["22.3842","22.9254","22.7083","22.2951",{"$nulls":3},"chromosome organization;ITP catabolic process;nucleoside triphosphate catabolic process;purine nucleotide catabolic process","dITP diphosphatase activity;identical protein binding;ITP diphosphatase activity;metal ion binding;NADH pyrophosphatase activity;nucleoside-triphosphate diphosphatase activity;nucleotide binding;XTP diphosphatase activity","cytoplasm;cytosol","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism",null,null,7,7,7,"42.3","42.3","42.3","21.445",0,"31.966",563560000,40,"0.156698",1,"0.15302","0.449462","sp|Q9BY32|ITPA_HUMAN","sp|Q9BY32|ITPA_HUMAN",4051,"Q9BY32","ITPA_HUMAN","Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}","nosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148};TPase {ECO:0000255|HAMAP-Rule:MF_03148}","ITPA"]
["18.4362","18.3446","19.2906","17.185",{"$nulls":3},"apical protein localization;cytoplasmic sequestering of CFTR protein;ER to Golgi vesicle-mediated transport;Golgi to plasma membrane transport;negative regulation of anion channel activity;negative regulation of protein localization to cell surface;protein homooligomerization;protein transport;spermatid nucleus differentiation","frizzled binding;GTPase regulator activity;ion channel binding;protein C-terminus binding;protein homodimerization activity","cell junction;cytoplasm;dendrite;Golgi apparatus;Golgi membrane;Golgi-associated vesicle membrane;lysosomal membrane;membrane;plasma membrane;postsynaptic density;postsynaptic membrane;protein complex;trans-Golgi network transport vesicle",{"$nulls":3},7,7,4,"21.4","21.4","11.5","50.519",0,"19.415",76823000,17,"0.0466491",1,"0.152568","0.144785","sp|Q9HD26|GOPC_HUMAN;tr|F5H1Y4|F5H1Y4_HUMAN","sp|Q9HD26|GOPC_HUMAN;tr|F5H1Y4|F5H1Y4_HUMAN",4340,"Q9HD26","GOPC_HUMAN","Golgi-associated PDZ and coiled-coil motif-containing protein",null,"GOPC"]
["19.3142","19.2835","19.6639","18.6303",{"$nulls":4},"metal ion binding",{"$nulls":4},2,2,2,"20.6","20.6","20.6","14.746","0.0004674","4.9113",45918000,9,"0.0986452",1,"0.15174","0.293476","tr|C9JYX8|C9JYX8_HUMAN;tr|C9J031|C9J031_HUMAN;tr|C9IY57|C9IY57_HUMAN;sp|Q9UHC7|MKRN1_HUMAN;tr|C9IZP5|C9IZP5_HUMAN;sp|Q13434|MKRN4_HUMAN","tr|C9JYX8|C9JYX8_HUMAN;tr|C9J031|C9J031_HUMAN;tr|C9IY57|C9IY57_HUMAN;sp|Q9UHC7|MKRN1_HUMAN;tr|C9IZP5|C9IZP5_HUMAN;sp|Q13434|MKRN4_HUMAN",4720,"C9JYX8","C9JYX8_HUMAN",null,null,"MKRN1"]
["21.7556","22.0411","21.9595","21.5346",{"$nulls":3},"ceramide translocation;G2/M transition of mitotic cell cycle;phospholipid translocation;positive regulation of anion channel activity;regulation of chloride transport;regulation of response to osmotic stress;response to drug;stem cell proliferation;transmembrane transport;transport","ATP binding;ATPase activity, coupled to transmembrane movement of substances;ceramide-translocating ATPase activity;phosphatidylcholine-translocating ATPase activity;phosphatidylethanolamine-translocating ATPase activity;transporter activity;xenobiotic transmembrane transporting ATPase activity","apical plasma membrane;cell surface;extracellular exosome;integral component of membrane;membrane;plasma membrane","ABC transporters;Bile secretion;Gastric cancer;MicroRNAs in cancer",null,null,34,34,34,"32.5","32.5","32.5","141.48",0,"220.5",2778200000,243,"0.211612",1,"0.151303","0.591189","sp|P08183|MDR1_HUMAN;sp|P21439|MDR3_HUMAN;tr|E7EWT8|E7EWT8_HUMAN;tr|H7C0M2|H7C0M2_HUMAN","sp|P08183|MDR1_HUMAN",913,"P08183","MDR1_HUMAN","Multidrug resistance protein 1",null,"ABCB1"]
["20.5833","20.1799","20.4568","20.0062",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;clathrin-dependent endocytosis;ephrin receptor signaling pathway;intracellular protein transport;low-density lipoprotein particle clearance;low-density lipoprotein particle receptor catabolic process;membrane organization;microtubule-based movement;neutrophil degranulation;regulation of defense response to virus by virus;Wnt signaling pathway, planar cell polarity pathway","disordered domain specific binding;lipid binding;protein kinase binding;protein transporter activity","AP-2 adaptor complex;clathrin-coated endocytic vesicle;clathrin-coated endocytic vesicle membrane;cytoplasmic vesicle;cytosol;endocytic vesicle membrane;endolysosome membrane;ficolin-1-rich granule membrane;plasma membrane;secretory granule membrane","Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Huntington disease;Synaptic vesicle cycle",null,null,34,25,25,"49.5",38,38,"103.96",0,"323.31",3086100000,254,"0.174602",1,"0.150034","0.496142","sp|O94973|AP2A2_HUMAN;tr|A0A0G2JS82|A0A0G2JS82_HUMAN;tr|A0A0G2JQM1|A0A0G2JQM1_HUMAN;tr|E9PR62|E9PR62_HUMAN;tr|A0A0G2JRF9|A0A0G2JRF9_HUMAN;tr|A0A0G2JQA4|A0A0G2JQA4_HUMAN;tr|A0A0G2JRS3|A0A0G2JRS3_HUMAN;tr|E9PNC4|E9PNC4_HUMAN;tr|A0A0G2JQT9|A0A0G2JQT9_HUMAN;tr|H0YEG0|H0YEG0_HUMAN;tr|A0A0G2JS17|A0A0G2JS17_HUMAN;tr|H0YDE9|H0YDE9_HUMAN;tr|E9PQP4|E9PQP4_HUMAN","sp|O94973|AP2A2_HUMAN;tr|A0A0G2JS82|A0A0G2JS82_HUMAN;tr|A0A0G2JQM1|A0A0G2JQM1_HUMAN",680,"O94973","AP2A2_HUMAN","AP-2 complex subunit alpha-2",null,"AP2A2"]
["17.6065","18.8099","18.8822","17.2354",{"$nulls":3},"activation of JUN kinase activity;androgen receptor signaling pathway;apoptotic process;cellular response to cadmium ion;cellular response to copper ion;cellular response to diamide;cellular response to heat;cellular response to sodium arsenite;cellular response to unfolded protein;chromatin remodeling;covalent chromatin modification;extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of transcription, DNA-templated;nucleosome assembly;positive regulation of neuron death;positive regulation of protein kinase activity;positive regulation of protein phosphorylation;regulation of protein ubiquitination;regulation of transcription, DNA-templated;transcription, DNA-templated;viral process","androgen receptor binding;enzyme binding;heat shock protein binding;histone binding;p53 binding;protein heterodimerization activity;protein homodimerization activity;protein kinase activator activity;protein kinase binding;protein N-terminus binding;signal transducer activity, downstream of receptor;SUMO binding;transcription coactivator activity;transcription corepressor activity;transcription factor binding;ubiquitin protein ligase binding","chromosome, centromeric region;cytoplasm;cytosol;nuclear body;nucleolus;nucleoplasm;nucleus;PML body;SWI/SNF superfamily-type complex","Amyotrophic lateral sclerosis (ALS);Apoptosis;Herpes simplex virus 1 infection;MAPK signaling pathway",null,null,13,13,13,"26.8","26.8","26.8","81.372",0,"80.711",1076700000,135,"0.0472346",1,"0.149424","0.146523","sp|Q9UER7|DAXX_HUMAN;tr|Q5STR5|Q5STR5_HUMAN;tr|Q4VX54|Q4VX54_HUMAN","sp|Q9UER7|DAXX_HUMAN",4693,"Q9UER7","DAXX_HUMAN","Death domain-associated protein 6",null,"DAXX"]
["16.3599","17.7668","16.8706","16.9589",{"$nulls":3},"immune response;transcription, DNA-templated","RNA polymerase II proximal promoter sequence-specific DNA binding;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding","intracellular membrane-bounded organelle;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"8.4","8.4","8.4","104.76","0.0013069","3.8074",26744000,9,"0.0692831",1,"0.148605","0.210839","sp|P22670|RFX1_HUMAN","sp|P22670|RFX1_HUMAN",1186,"P22670","RFX1_HUMAN","MHC class II regulatory factor RFX1",null,"RFX1"]
["23.1319","22.7658","23.1717","22.431",{"$nulls":4},"ATP binding;protein serine/threonine kinase activity",{"$nulls":4},14,14,14,"48.8","48.8","48.8","45.31",0,"323.31",14181000000,465,"0.121916",1,"0.147491","0.357005","tr|E7EU96|E7EU96_HUMAN;sp|P68400|CSK21_HUMAN;tr|Q5U5J2|Q5U5J2_HUMAN;sp|Q8NEV1|CSK23_HUMAN;tr|A0A087WY74|A0A087WY74_HUMAN;tr|V9GYA2|V9GYA2_HUMAN;tr|V9GY80|V9GY80_HUMAN","tr|E7EU96|E7EU96_HUMAN;sp|P68400|CSK21_HUMAN;tr|Q5U5J2|Q5U5J2_HUMAN;sp|Q8NEV1|CSK23_HUMAN",1963,"E7EU96","E7EU96_HUMAN",null,null,"CSNK2A1"]
["26.2229","26.6209","26.3672","26.1854",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosome biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;rRNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleoplasm;nucleus;ribosome;small ribosomal subunit","Ribosome",null,null,16,16,16,"58.6","58.6","58.6","17.718",0,"323.31",69748000000,1206,"0.241045",1,"0.145643","0.665792","sp|P62269|RS18_HUMAN;tr|A0A0G2JQH2|A0A0G2JQH2_HUMAN;tr|Q5GGW2|Q5GGW2_HUMAN;tr|J3JS69|J3JS69_HUMAN","sp|P62269|RS18_HUMAN",1883,"P62269","RS18_HUMAN","40S ribosomal protein S18",null,"RPS18"]
["20.866","21.7388","21.0033","21.3112",{"$nulls":4},"metal ion binding;phosphoprotein phosphatase activity",{"$nulls":4},11,3,3,"46.4","9.5","9.5","34.95",0,"19.46",480520000,29,"0.105984",1,"0.145142","0.313677","tr|F8VYE8|F8VYE8_HUMAN;sp|P36873|PP1G_HUMAN;tr|F8VR82|F8VR82_HUMAN;tr|F8W0W8|F8W0W8_HUMAN;tr|A0A087WYY5|A0A087WYY5_HUMAN;tr|F8WE71|F8WE71_HUMAN;tr|F8W0V8|F8W0V8_HUMAN;tr|H0Y3Y6|H0Y3Y6_HUMAN","tr|F8VYE8|F8VYE8_HUMAN;sp|P36873|PP1G_HUMAN;tr|F8VR82|F8VR82_HUMAN;tr|F8W0W8|F8W0W8_HUMAN;tr|A0A087WYY5|A0A087WYY5_HUMAN",1413,"F8VYE8","F8VYE8_HUMAN","Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273}",null,"PPP1CC"]
["25.4765","25.3811","25.651","24.9174",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},12,12,2,"50.5","50.5","14.5","22.975",0,"288.57",17756000000,795,"0.134595",1,"0.144622","0.391017","tr|X1WI28|X1WI28_HUMAN;sp|P27635|RL10_HUMAN;tr|H7C123|H7C123_HUMAN;tr|H7C2C5|H7C2C5_HUMAN;tr|B8A6G2|B8A6G2_HUMAN;tr|A6QRI9|A6QRI9_HUMAN;sp|Q96L21|RL10L_HUMAN;tr|H7C2U2|H7C2U2_HUMAN","tr|X1WI28|X1WI28_HUMAN;sp|P27635|RL10_HUMAN;tr|H7C123|H7C123_HUMAN;tr|H7C2C5|H7C2C5_HUMAN",1252,"X1WI28","X1WI28_HUMAN",null,null,"RPL10"]
["16.7412","16.2432","16.7688","15.9272",{"$nulls":3},"protein transport","GTP binding;GTPase activator activity;GTPase activity;metal ion binding;phospholipid binding","cytoplasm","Endocytosis",null,null,14,12,3,23,"20.2","4.9","94.469",0,"76.103",801000000,105,"0.099166",1,"0.144193","0.294915","sp|Q9UPQ3|AGAP1_HUMAN","sp|Q9UPQ3|AGAP1_HUMAN",4868,"Q9UPQ3","AGAP1_HUMAN","Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1","GAP-1","AGAP1"]
["15.4881","15.0241","16.0839","14.1404",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;intracellular protein transport;intra-Golgi vesicle-mediated transport;protein glycosylation;protein localization to organelle;protein stabilization;retrograde vesicle-mediated transport, Golgi to ER","protein transporter activity","cis-Golgi network;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;Golgi transport complex;trans-Golgi network membrane",{"$nulls":3},2,2,2,"2.5","2.5","2.5","94.095","0.0010975","3.9026",25603000,6,"0.0464127",1,"0.143945","0.144082","sp|Q96JB2|COG3_HUMAN","sp|Q96JB2|COG3_HUMAN",3741,"Q96JB2","COG3_HUMAN","Conserved oligomeric Golgi complex subunit 3","OG complex subunit 3","COG3"]
["15.3073","16.1875","15.9506","15.2579",{"$nulls":4},"RNA binding;ubiquitin binding;ubiquitin-protein transferase activity;zinc ion binding","cytosol;nucleoplasm",{"$nulls":3},6,6,6,"3.2","3.2","3.2","308.57",0,"13.366",72034000,19,"0.0850319",1,"0.14311","0.255545","tr|E7EMW7|E7EMW7_HUMAN;sp|O95071|UBR5_HUMAN;tr|E7ET84|E7ET84_HUMAN","tr|E7EMW7|E7EMW7_HUMAN;sp|O95071|UBR5_HUMAN",688,"E7EMW7","E7EMW7_HUMAN",null,null,"UBR5"]
[1,"16.9047",1,"16.623",{"$nulls":4},"tRNA (guanine-N2-)-methyltransferase activity;tRNA binding",{"$nulls":4},2,2,2,"4.5","4.5","4.5","53.42","0.0087142","2.3094",15492000,2,"0.00389703",1,"0.140831","0.0126338","sp|Q7Z4G4|TRM11_HUMAN;tr|H0Y768|H0Y768_HUMAN;tr|Q5JY02|Q5JY02_HUMAN;tr|K7ENP1|K7ENP1_HUMAN","sp|Q7Z4G4|TRM11_HUMAN;tr|H0Y768|H0Y768_HUMAN;tr|Q5JY02|Q5JY02_HUMAN;tr|K7ENP1|K7ENP1_HUMAN",3002,"Q7Z4G4","TRM11_HUMAN","tRNA (guanine(10)-N2)-methyltransferase homolog",null,"TRMT11"]
["15.0235","17.884","16.2289","16.3984",{"$nulls":3},"activation of GTPase activity;cell cycle;intracellular protein transport;regulation of GTPase activity;regulation of vesicle fusion","GTPase activator activity;Rab GTPase binding;tubulin binding","centrosome;cytosol;endomembrane system;microtubule associated complex",{"$nulls":3},6,6,5,"7.3","7.3","5.8","121.74",0,"19.659",69121000,12,"0.0310371",1,"0.140088","0.0977736","sp|Q9Y3P9|RBGP1_HUMAN;tr|E9PS63|E9PS63_HUMAN","sp|Q9Y3P9|RBGP1_HUMAN",4995,"Q9Y3P9","RBGP1_HUMAN","Rab GTPase-activating protein 1",null,"RABGAP1"]
["20.631","18.779","19.7721","19.359",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;positive regulation of viral transcription;regulation of gene silencing by miRNA;RNA metabolic process;snRNA transcription from RNA polymerase II promoter;somatic stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;transcription, DNA-templated;transcription-coupled nucleotide-excision repair","DNA binding;DNA-directed 5'-3' RNA polymerase activity;protein dimerization activity","cytosol;DNA-directed RNA polymerase II, core complex;microtubule cytoskeleton;nucleoplasm;nucleus","Huntington disease;RNA polymerase",null,null,8,8,8,"46.5","46.5","46.5","31.441",0,"38.891",455030000,70,"0.0473871",1,"0.139448","0.146976","sp|P19387|RPB3_HUMAN;tr|H3BRR2|H3BRR2_HUMAN","sp|P19387|RPB3_HUMAN",1133,"P19387","RPB3_HUMAN","DNA-directed RNA polymerase II subunit RPB3 {ECO:0000305}","NA polymerase II subunit 3;NA polymerase II subunit B3","POLR2C"]
["20.1847","20.338","20.1696","20.0754",{"$nulls":9},24,24,24,"17.2","17.2","17.2","231.71",0,"134.39",1052000000,102,"0.58051",1,"0.138865","1.54336","tr|A0A0J9YWL0|A0A0J9YWL0_HUMAN;sp|Q9Y4K1|AIM1_HUMAN;tr|Q96QW7|Q96QW7_HUMAN","tr|A0A0J9YWL0|A0A0J9YWL0_HUMAN;sp|Q9Y4K1|AIM1_HUMAN",5159,"A0A0J9YWL0","A0A0J9YWL0_HUMAN",null,null,"CRYBG1"]
["25.177","25.0224","25.3446","24.5787",{"$nulls":3},"cell proliferation;cellular response to hydrogen peroxide;cellular response to UV;DNA damage response, detection of DNA damage;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA ligation;epithelial cell differentiation;error-free translesion synthesis;error-prone translesion synthesis;estrous cycle;heart development;leading strand elongation;liver regeneration;mismatch repair;mitotic telomere maintenance via semi-conservative replication;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of deoxyribonuclease activity;positive regulation of DNA repair;positive regulation of DNA replication;protein sumoylation;protein ubiquitination;regulation of transcription involved in G1/S transition of mitotic cell cycle;replication fork processing;response to cadmium ion;response to dexamethasone;response to estradiol;response to L-glutamate;telomere maintenance;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","chromatin binding;damaged DNA binding;dinucleotide insertion or deletion binding;DNA polymerase binding;DNA polymerase processivity factor activity;enzyme binding;estrogen receptor binding;histone acetyltransferase binding;identical protein binding;MutLalpha complex binding;purine-specific mismatch base pair DNA N-glycosylase activity;receptor tyrosine kinase binding","centrosome;DNA replication factor C complex;extracellular exosome;nuclear body;nuclear chromosome, telomeric region;nuclear replication fork;nucleoplasm;nucleus;PCNA complex;PCNA-p21 complex;replication fork;replisome","Base excision repair;Cell cycle;DNA replication;Hepatitis B;Mismatch repair;Nucleotide excision repair;Tight junction",null,null,13,13,13,"71.6","71.6","71.6","28.768",0,"323.31",4491600000,124,"0.120562",1,"0.138038","0.353349","sp|P12004|PCNA_HUMAN","sp|P12004|PCNA_HUMAN",1006,"P12004","PCNA_HUMAN","Proliferating cell nuclear antigen","CNA","PCNA"]
[1,"19.7626",1,"19.4881",{"$nulls":3},"protein N-linked glycosylation via arginine",null,"integral component of membrane;oligosaccharyltransferase complex",{"$nulls":3},1,1,1,"12.5","12.5","12.5","14.678","0.0023261","3.3802",54207000,12,"0.00321185",1,"0.137244","0.0104206","sp|Q8N6L1|KTAP2_HUMAN","sp|Q8N6L1|KTAP2_HUMAN",3254,"Q8N6L1","KTAP2_HUMAN","Keratinocyte-associated protein 2","CP-2","KRTCAP2"]
["24.4068","24.3915","24.6309","23.8932",{"$nulls":3},"L-phenylalanine catabolic process;positive regulation of transcription, DNA-templated;protein heterooligomerization;protein homotetramerization;regulation of protein homodimerization activity;tetrahydrobiopterin biosynthetic process;transcription, DNA-templated","4-alpha-hydroxytetrahydrobiopterin dehydratase activity;identical protein binding;phenylalanine 4-monooxygenase activity;transcription coactivator activity","cytosol;extracellular exosome;nucleoplasm;nucleus","Folate biosynthesis;Metabolic pathways",null,null,6,6,6,"57.7","57.7","57.7","11.999",0,"39.996",1171600000,38,"0.127353",1,"0.137109","0.371636","sp|P61457|PHS_HUMAN","sp|P61457|PHS_HUMAN",1847,"P61457","PHS_HUMAN","Pterin-4-alpha-carbinolamine dehydratase","HS","PCBD1"]
["23.8679","22.5684","23.8901","22.2721",{"$nulls":3},"cell death;COPII-coated vesicle budding;ER to Golgi vesicle-mediated transport;membrane fusion;negative regulation by host of viral genome replication;neuron projection development;neutrophil degranulation;positive regulation by host of viral genome replication;positive regulation by host of viral release from host cell;positive regulation of I-kappaB kinase/NF-kappaB signaling;protein localization to endoplasmic reticulum;sphingolipid biosynthetic process","cadherin binding;FFAT motif binding;microtubule binding;protein domain specific binding;protein heterodimerization activity;signal transducer activity","azurophil granule membrane;bicellular tight junction;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane;integral component of membrane;microtubule cytoskeleton;nuclear membrane;plasma membrane;vesicle","Cholesterol metabolism",null,null,11,11,10,"48.6","48.6","43.8","27.893",0,"134.34",1784900000,109,"0.0423809",1,"0.13703","0.132059","sp|Q9P0L0|VAPA_HUMAN;tr|J3QKM9|J3QKM9_HUMAN","sp|Q9P0L0|VAPA_HUMAN",4618,"Q9P0L0","VAPA_HUMAN","Vesicle-associated membrane protein-associated protein A","AMP-A;AMP-associated protein A;AP-A","VAPA"]
["18.3493","16.3719","16.3713","18.0781",{"$nulls":9},10,10,10,"61.8","61.8","61.8","28.17",0,"48.722",499530000,53,"0.0330935",1,"0.135882","0.104041","sp|Q96C57|CL043_HUMAN;tr|F5H7W8|F5H7W8_HUMAN;tr|E7ENF1|E7ENF1_HUMAN;tr|G5EA44|G5EA44_HUMAN;tr|F5H3K2|F5H3K2_HUMAN;tr|F5H8B7|F5H8B7_HUMAN;tr|H0YGK4|H0YGK4_HUMAN","sp|Q96C57|CL043_HUMAN;tr|F5H7W8|F5H7W8_HUMAN;tr|E7ENF1|E7ENF1_HUMAN;tr|G5EA44|G5EA44_HUMAN;tr|F5H3K2|F5H3K2_HUMAN;tr|F5H8B7|F5H8B7_HUMAN",3628,"Q96C57","CL043_HUMAN","Uncharacterized protein C12orf43",null,"C12orf43"]
["20.6588","20.8196","20.2063","21.001",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;actin filament network formation;bone development","actin filament binding;calcium ion binding","actin filament;actin filament bundle;cytoplasm;cytosol;plasma membrane",{"$nulls":3},19,16,16,"37.8","32.2","32.2","70.81",0,"106.9",535690000,50,"0.113549",1,"0.135532","0.334338","sp|P13797|PLST_HUMAN;tr|A0A0A0MSQ0|A0A0A0MSQ0_HUMAN;tr|U3KQI3|U3KQI3_HUMAN;tr|H7C4N2|H7C4N2_HUMAN;sp|P13796|PLSL_HUMAN;tr|Q5TBN3|Q5TBN3_HUMAN;tr|F2Z2Z9|F2Z2Z9_HUMAN","sp|P13797|PLST_HUMAN;tr|A0A0A0MSQ0|A0A0A0MSQ0_HUMAN",1032,"P13797","PLST_HUMAN","Plastin-3",null,"PLS3"]
["21.7345","21.9243","21.9013","21.4891",{"$nulls":3},"peptide metabolic process","aminopeptidase activity;identical protein binding;metalloaminopeptidase activity;zinc ion binding","blood microparticle;cytoplasm;cytosol;nucleus",{"$nulls":3},8,8,8,"24.8","24.8","24.8","52.428",0,"54.052",542120000,37,"0.211811",1,"0.134257","0.591695","sp|Q9ULA0|DNPEP_HUMAN;tr|E7ETB3|E7ETB3_HUMAN;tr|E7EMB6|E7EMB6_HUMAN;tr|F8WAN0|F8WAN0_HUMAN;tr|B9ZVU2|B9ZVU2_HUMAN;tr|C9JBE1|C9JBE1_HUMAN;tr|C9J1E2|C9J1E2_HUMAN;tr|E7EPX3|E7EPX3_HUMAN;tr|E5RJ35|E5RJ35_HUMAN;tr|C9JRG3|C9JRG3_HUMAN","sp|Q9ULA0|DNPEP_HUMAN;tr|E7ETB3|E7ETB3_HUMAN;tr|E7EMB6|E7EMB6_HUMAN;tr|F8WAN0|F8WAN0_HUMAN",4806,"Q9ULA0","DNPEP_HUMAN","Aspartyl aminopeptidase",null,"DNPEP"]
["19.7178","19.4389","19.8372","19.054",{"$nulls":3},"mRNA splicing, via spliceosome;nuclear import;protein complex assembly;regulation of translation;spliceosomal snRNP assembly;translation","mRNA 3'-UTR binding;ribosome binding;RNA 7-methylguanosine cap binding;RNA binding;snRNA binding;U1 snRNA binding;U4 snRNA binding;U4atac snRNA binding","cytoplasm;cytosol;Gemini of coiled bodies;membrane;nuclear body;nucleoplasm;SMN complex;SMN-Gemin2 complex;SMN-Sm protein complex","RNA transport",null,null,18,18,18,"17.5","17.5","17.5","168.59",0,"73.143",790560000,92,"0.108078",1,"0.132771","0.319412","sp|Q8TEQ6|GEMI5_HUMAN","sp|Q8TEQ6|GEMI5_HUMAN",3398,"Q8TEQ6","GEMI5_HUMAN","Gem-associated protein 5","emin5","GEMIN5"]
["20.9413","20.2112","21.2035","19.6877",{"$nulls":3},"negative regulation of cell proliferation;negative regulation of histone acetylation;negative regulation of histone H4 acetylation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription from RNA polymerase II promoter by histone modification;negative regulation of transcription, DNA-templated;positive regulation of histone deacetylation;protein phosphorylation;regulation of cell cycle;transcription, DNA-templated;viral genome replication;white fat cell differentiation","DNA binding transcription factor activity;glyoxylate reductase (NADP) activity;hydroxypyruvate reductase activity;identical protein binding;NAD binding;protein C-terminus binding;protein domain specific binding;protein homodimerization activity;repressing transcription factor binding;RNA polymerase II transcription corepressor activity;transcription factor binding","cytosol;nucleoplasm;nucleus;transcription factor complex;transcriptional repressor complex","Chronic myeloid leukemia;Notch signaling pathway;Pathways in cancer;Wnt signaling pathway",null,null,9,7,7,"22.3","18.4","18.4","47.535",0,"32.476",324900000,27,"0.0502137",1,"0.130676","0.155343","sp|Q13363|CTBP1_HUMAN;tr|D6RAX2|D6RAX2_HUMAN;tr|E7ESU7|E7ESU7_HUMAN;tr|E7EPF8|E7EPF8_HUMAN;tr|H0Y8W7|H0Y8W7_HUMAN;tr|E9PGB1|E9PGB1_HUMAN;tr|H0Y9M9|H0Y9M9_HUMAN;tr|E7EUB3|E7EUB3_HUMAN;tr|H0Y8U5|H0Y8U5_HUMAN","sp|Q13363|CTBP1_HUMAN;tr|D6RAX2|D6RAX2_HUMAN",2240,"Q13363","CTBP1_HUMAN","C-terminal-binding protein 1","tBP1","CTBP1"]
["21.5033","21.0691","21.8299","20.4838",{"$nulls":3},"intracellular transport",null,"nucleoplasm",{"$nulls":3},15,15,1,"40.1","40.1","2.8","52.894",0,"50.49",537570000,49,"0.0596382",1,"0.129389","0.182971","tr|B7Z7F3|B7Z7F3_HUMAN","tr|B7Z7F3|B7Z7F3_HUMAN",5179,"B7Z7F3","B7Z7F3_HUMAN",null,null,"RANBP3"]
["17.9884","16.7559","17.4349","17.0508",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell proliferation;cellular response to cell-matrix adhesion;G1/S transition of mitotic cell cycle;G2/M transition of mitotic cell cycle;positive regulation of intracellular estrogen receptor signaling pathway;positive regulation of protein polyubiquitination;positive regulation of smooth muscle cell proliferation;post-translational protein modification;protein deubiquitination;protein polyubiquitination;regulation of apoptotic process;regulation of cell cycle","identical protein binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytosol;nucleolus;nucleoplasm;nucleus;SCF ubiquitin ligase complex","Cell cycle;Epstein-Barr virus infection;FoxO signaling pathway;mTOR signaling pathway;Pathways in cancer;Small cell lung cancer;Ubiquitin mediated proteolysis;Viral carcinogenesis",null,null,3,3,3,"8.5","8.5","8.5","47.76","0.00025913","7.1593",48101000,5,"0.0656087",1,"0.129268","0.200268","sp|Q13309|SKP2_HUMAN;tr|A0A0A0MTL5|A0A0A0MTL5_HUMAN;tr|D6R9R7|D6R9R7_HUMAN","sp|Q13309|SKP2_HUMAN;tr|A0A0A0MTL5|A0A0A0MTL5_HUMAN;tr|D6R9R7|D6R9R7_HUMAN",2233,"Q13309","SKP2_HUMAN","S-phase kinase-associated protein 2",null,"SKP2"]
["20.5285","20.6811","20.8276","20.127",{"$nulls":3},"cellular response to DNA damage stimulus;protein de-ADP-ribosylation;purine nucleoside metabolic process","deacetylase activity;hydrolase activity, acting on glycosyl bonds","mitochondrion;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"22.5","22.5","22.5","35.505",0,"16.923",195730000,13,"0.121345",1,"0.127438","0.355464","sp|Q9BQ69|MACD1_HUMAN","sp|Q9BQ69|MACD1_HUMAN",3912,"Q9BQ69","MACD1_HUMAN","O-acetyl-ADP-ribose deacetylase MACROD1",null,"MACROD1"]
["16.9651","16.9251","16.6676","16.9693",{"$nulls":3},"ATP-dependent chromatin remodeling;brain development;canonical Wnt signaling pathway;covalent chromatin modification;digestive tract development;in utero embryonic development;negative regulation of canonical Wnt signaling pathway;negative regulation of fibroblast apoptotic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of Wnt signaling pathway;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase III promoter;positive regulation of transcription, DNA-templated;transcription, DNA-templated","armadillo repeat domain binding;ATP binding;beta-catenin binding;chromatin binding;DNA binding;DNA helicase activity;DNA-dependent ATPase activity;histone binding;methylated histone binding;p53 binding","MLL1 complex;nucleoplasm;nucleus;protein complex","Wnt signaling pathway",null,null,44,44,40,"25.3","25.3","23.8","290.52",0,"228.14",2593400000,296,"0.307385",1,"0.126657","0.832426","sp|Q9HCK8|CHD8_HUMAN;tr|H0YJG4|H0YJG4_HUMAN;tr|G3V2T9|G3V2T9_HUMAN;tr|H0YJA4|H0YJA4_HUMAN","sp|Q9HCK8|CHD8_HUMAN",4330,"Q9HCK8","CHD8_HUMAN","Chromodomain-helicase-DNA-binding protein 8 {ECO:0000255|HAMAP-Rule:MF_03071}","HD-8 {ECO:0000255|HAMAP-Rule:MF_03071}","CHD8"]
["19.2511","18.8015","19.8202","17.9821",{"$nulls":5},"integral component of membrane",{"$nulls":3},6,6,6,"29.5","29.5","29.5","28.214",0,"14.487",343710000,33,"0.0424471",1,"0.125137","0.132257","tr|E5RGS2|E5RGS2_HUMAN;sp|Q9H6H4|REEP4_HUMAN","tr|E5RGS2|E5RGS2_HUMAN;sp|Q9H6H4|REEP4_HUMAN",4228,"E5RGS2","E5RGS2_HUMAN","Receptor expression-enhancing protein {ECO:0000256|RuleBase:RU362006}",null,"REEP4"]
["21.7203","21.7146","21.8845","21.302",{"$nulls":3},"cell growth;negative regulation of apoptotic process","ATP binding","integral component of membrane;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrion",{"$nulls":3},35,35,1,"54.6","54.6","1.3","71.368",0,"231.88",5458100000,351,"0.147956",1,"0.124219","0.426465","sp|Q9NVI7|ATD3A_HUMAN;tr|Q5SV16|Q5SV16_HUMAN","sp|Q9NVI7|ATD3A_HUMAN",4492,"Q9NVI7","ATD3A_HUMAN","ATPase family AAA domain-containing protein 3A {ECO:0000312|HGNC:HGNC:25567}",null,"ATAD3A"]
["24.2987","24.768","24.6443","24.1758",{"$nulls":3},"in utero embryonic development;liver development;negative regulation of neuron projection development;N-glycan processing;protein heterooligomerization;renal system development","calcium ion binding;RNA binding","endoplasmic reticulum",{"$nulls":3},20,20,14,"45.6","45.6","34.2","60.192",0,"243.58",3762600000,205,"0.127444",1,"0.123302","0.37188","tr|K7ELL7|K7ELL7_HUMAN;sp|P14314|GLU2B_HUMAN;tr|K7EPW7|K7EPW7_HUMAN;tr|K7EKX1|K7EKX1_HUMAN;tr|K7EJ70|K7EJ70_HUMAN;tr|K7EIP3|K7EIP3_HUMAN;tr|K7EL27|K7EL27_HUMAN","tr|K7ELL7|K7ELL7_HUMAN;sp|P14314|GLU2B_HUMAN",5282,"K7ELL7","K7ELL7_HUMAN",null,null,"PRKCSH"]
["21.9642","22.2499","21.9789","21.992",{"$nulls":3},"protein targeting to ER;response to drug;SRP-dependent cotranslational protein targeting to membrane","7S RNA binding;endoplasmic reticulum signal peptide binding;protein domain specific binding;RNA binding;signal recognition particle binding","cytosol;endoplasmic reticulum;focal adhesion;nucleolus;ribosome;signal recognition particle;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,20,20,20,"41.9","41.9","41.9","70.729",0,"153.34",1699900000,121,"0.314631",1,"0.121627","0.850594","sp|Q9UHB9|SRP68_HUMAN","sp|Q9UHB9|SRP68_HUMAN",4719,"Q9UHB9","SRP68_HUMAN","Signal recognition particle subunit SRP68","RP68","SRP68"]
["23.3237","23.1903","23.581","22.6905",{"$nulls":3},"fatty acid beta-oxidation;protein homotetramerization","2,4-dienoyl-CoA reductase (NADPH) activity;NADPH binding;oxidoreductase activity, acting on NAD(P)H","cytosol;extracellular exosome;mitochondrial matrix;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},13,13,13,"44.2","44.2","44.2","36.067",0,"165.69",1760600000,108,"0.089998",1,"0.121303","0.269454","sp|Q16698|DECR_HUMAN;tr|E5RJG7|E5RJG7_HUMAN;tr|E5RFV2|E5RFV2_HUMAN;tr|E5RJD2|E5RJD2_HUMAN;tr|E5RID6|E5RID6_HUMAN;tr|H0YAW3|H0YAW3_HUMAN","sp|Q16698|DECR_HUMAN;tr|E5RJG7|E5RJG7_HUMAN;tr|E5RFV2|E5RFV2_HUMAN",2564,"Q16698","DECR_HUMAN","2,4-dienoyl-CoA reductase, mitochondrial",null,"DECR1"]
["21.1659","21.611","21.5452","20.9902",{"$nulls":3},"cellular response to UV;mitotic cell cycle;negative regulation of inflammatory response;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of stress-activated MAPK cascade","ATP binding;protein serine/threonine kinase activity","nucleus",{"$nulls":3},7,7,7,"27.3","27.3","27.3","36.085",0,"20.266",431680000,35,"0.115407",1,"0.120737","0.339387","sp|Q96KB5|TOPK_HUMAN;tr|E5RFX4|E5RFX4_HUMAN;tr|E5RIE1|E5RIE1_HUMAN","sp|Q96KB5|TOPK_HUMAN;tr|E5RFX4|E5RFX4_HUMAN",3755,"Q96KB5","TOPK_HUMAN","Lymphokine-activated killer T-cell-originated protein kinase",null,"PBK"]
["23.7894","23.9215","23.8193","23.6514",{"$nulls":3},"alternative mRNA splicing, via spliceosome;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;RNA metabolic process","protein domain specific binding;RNA binding","catalytic step 2 spliceosome;extracellular exosome;extracellular matrix;integral component of plasma membrane;membrane;nuclear matrix;nucleolus;nucleoplasm;paraspeckles;spliceosomal complex","Spliceosome",null,null,30,30,15,"54.2","54.2","31.9","77.515",0,"239.72",6013500000,240,"0.422772",1,"0.120089","1.12408","sp|P52272|HNRPM_HUMAN;tr|A0A087X0X3|A0A087X0X3_HUMAN;tr|M0R2I7|M0R2I7_HUMAN;tr|M0R2T0|M0R2T0_HUMAN;tr|M0R019|M0R019_HUMAN;tr|M0R0N3|M0R0N3_HUMAN;tr|M0QYQ7|M0QYQ7_HUMAN;tr|M0QY96|M0QY96_HUMAN;tr|M0R0Y6|M0R0Y6_HUMAN;tr|M0QYL3|M0QYL3_HUMAN","sp|P52272|HNRPM_HUMAN;tr|A0A087X0X3|A0A087X0X3_HUMAN",1679,"P52272","HNRPM_HUMAN","Heterogeneous nuclear ribonucleoprotein M","nRNP M","HNRNPM"]
["15.2594",1,"15.0227",1,{"$nulls":3},"snRNA processing",null,"integrator complex",{"$nulls":3},1,1,1,"1.1","1.1","1.1","133.38","0.0072663","2.4829",7554200,3,"0.00364971",1,"0.118349","0.0118353","tr|J3KMZ7|J3KMZ7_HUMAN;sp|Q9H0H0|INT2_HUMAN","tr|J3KMZ7|J3KMZ7_HUMAN;sp|Q9H0H0|INT2_HUMAN",4136,"J3KMZ7","J3KMZ7_HUMAN",null,null,"INTS2"]
["18.9167","20.7265","19.5284","19.8794",{"$nulls":3},"cell proliferation;cellular response to antibiotic;cellular response to UV-B;heart development;immune response;intrinsic apoptotic signaling pathway in response to DNA damage;prostate gland stromal morphogenesis;regulation of gene expression;response to organic substance;response to zinc ion","AT DNA binding;DNA binding, bending;peptide binding;zinc ion binding","cytoplasm",{"$nulls":3},2,2,2,"28.6","28.6","28.6","8.5328","0.0063606","2.6111",15802000,2,"0.040918",1,"0.117685","0.127676","sp|P50238|CRIP1_HUMAN;tr|K4DIB9|K4DIB9_HUMAN;tr|H3BRQ4|H3BRQ4_HUMAN","sp|P50238|CRIP1_HUMAN;tr|K4DIB9|K4DIB9_HUMAN;tr|H3BRQ4|H3BRQ4_HUMAN",1620,"P50238","CRIP1_HUMAN","Cysteine-rich protein 1","RP-1","CRIP1"]
["23.1232","22.4636","23.5101","21.8416",{"$nulls":3},"protein methylation;protein repair","cadherin binding;protein-L-isoaspartate (D-aspartate) O-methyltransferase activity","cytoplasm;cytosol;extracellular exosome;extracellular vesicle",{"$nulls":3},8,8,8,"52.4","52.4","52.4","24.636",0,"109.99",897510000,33,"0.0420167",1,"0.11749","0.130969","sp|P22061|PIMT_HUMAN;tr|A0A0A0MRJ6|A0A0A0MRJ6_HUMAN;tr|H7BY58|H7BY58_HUMAN;tr|F6S8N6|F6S8N6_HUMAN;tr|C9J0F2|C9J0F2_HUMAN;tr|F8WDT3|F8WDT3_HUMAN;tr|F8WAV5|F8WAV5_HUMAN;tr|F8WAX2|F8WAX2_HUMAN","sp|P22061|PIMT_HUMAN;tr|A0A0A0MRJ6|A0A0A0MRJ6_HUMAN;tr|H7BY58|H7BY58_HUMAN;tr|F6S8N6|F6S8N6_HUMAN",1176,"P22061","PIMT_HUMAN","Protein-L-isoaspartate(D-aspartate) O-methyltransferase","IMT","PCMT1"]
["20.2105","20.2347","20.1106","20.1003",{"$nulls":3},"anterior/posterior pattern specification;blood vessel morphogenesis;fertilization;forebrain development;limb development;lipid metabolic process;maternal placenta development;negative regulation of cyclin-dependent protein serine/threonine kinase activity;negative regulation of endothelial cell migration;negative regulation of endothelial cell proliferation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;neuron migration;placenta blood vessel development;positive regulation of systemic arterial blood pressure;positive regulation of transcription, DNA-templated;radial pattern formation;regulation of transcription from RNA polymerase II promoter;regulation of transcription involved in lymphatic endothelial cell fate commitment;response to estradiol;signal transduction;skeletal muscle tissue development;transcription, DNA-templated;trophoblast giant cell differentiation","DNA binding transcription factor activity;nuclear receptor activity;protein homodimerization activity;retinoic acid binding;sequence-specific DNA binding;steroid hormone receptor activity;transcription corepressor activity;zinc ion binding","nucleus",{"$nulls":3},9,9,8,"28.5","28.5","26.6","45.571",0,"55.938",1177300000,86,"1.90933",1,"0.117135","8.9253","sp|P24468|COT2_HUMAN;tr|F1DAL9|F1DAL9_HUMAN;sp|P10589|COT1_HUMAN;tr|H3BTC2|H3BTC2_HUMAN","sp|P24468|COT2_HUMAN",1210,"P24468","COT2_HUMAN","COUP transcription factor 2","OUP-TF2","NR2F2"]
["20.9079","20.3141","20.8626","20.1277",{"$nulls":3},"actin cytoskeleton organization;actin filament severing;multicellular organism development;regulation of transcription, DNA-templated;transcription, DNA-templated","actin binding;actin filament binding","brush border;cytosol;focal adhesion;microtubule organizing center;nucleoplasm",{"$nulls":3},18,18,14,"19.1","19.1","14.6","144.75",0,"189.72",1181800000,95,"0.0813551",1,"0.115842","0.245191","sp|Q13045|FLII_HUMAN;tr|J3QLR6|J3QLR6_HUMAN;tr|K7EQZ7|K7EQZ7_HUMAN;tr|J3QQQ2|J3QQQ2_HUMAN;tr|J3QQU5|J3QQU5_HUMAN","sp|Q13045|FLII_HUMAN",2197,"Q13045","FLII_HUMAN","Protein flightless-1 homolog",null,"FLII"]
["21.0031","20.601","20.5268","20.8458",{"$nulls":3},"beta-catenin-TCF complex assembly;cell cycle;cellular response to lipopolysaccharide;endodermal cell fate commitment;histone H2B ubiquitination;histone monoubiquitination;mRNA polyadenylation;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of epithelial cell proliferation;negative regulation of fibroblast proliferation;negative regulation of G1/S transition of mitotic cell cycle;negative regulation of myeloid cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell cycle G1/S phase transition;positive regulation of mRNA 3'-end processing;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;positive regulation of Wnt signaling pathway;protein destabilization;protein ubiquitination;recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex;regulation of cell growth;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;Wnt signaling pathway","RNA polymerase II core binding;transcription factor activity, RNA polymerase II transcription factor binding","Cdc73/Paf1 complex;cytosol;nuclear chromosome, telomeric region;nucleoplasm;nucleus",{"$nulls":3},18,18,18,"38.4","38.4","38.4","60.576",0,"58.282",863800000,87,"0.157321",1,"0.115774","0.451096","sp|Q6P1J9|CDC73_HUMAN","sp|Q6P1J9|CDC73_HUMAN",2848,"Q6P1J9","CDC73_HUMAN","Parafibromin",null,"CDC73"]
["22.1358","22.4585","22.3737","21.9912",{"$nulls":3},"mRNA splice site selection;RNA splicing","DNA binding;mRNA binding;RNA binding","nuclear speck;nucleoplasm;nucleus;U1 snRNP;U2-type prespliceosome",{"$nulls":3},12,12,12,"24.8","24.8","24.8","51.466",0,"292.12",2322100000,125,"0.160177",1,"0.114734","0.458574","sp|O95232|LC7L3_HUMAN;tr|J3KPP4|J3KPP4_HUMAN;tr|D6RDI2|D6RDI2_HUMAN;tr|D6RHH0|D6RHH0_HUMAN;tr|U3KQT3|U3KQT3_HUMAN;tr|E7EN55|E7EN55_HUMAN;tr|C9JL41|C9JL41_HUMAN;tr|H0YBV7|H0YBV7_HUMAN;tr|H0YAR4|H0YAR4_HUMAN;tr|H0YA81|H0YA81_HUMAN","sp|O95232|LC7L3_HUMAN;tr|J3KPP4|J3KPP4_HUMAN;tr|D6RDI2|D6RDI2_HUMAN",705,"O95232","LC7L3_HUMAN","Luc7-like protein 3",null,"LUC7L3"]
["24.8165","25.3138","24.7894","25.1116",{"$nulls":3},"'de novo' IMP biosynthetic process;purine nucleobase biosynthetic process;purine ribonucleoside monophosphate biosynthetic process","ATP binding;cadherin binding;identical protein binding;phosphoribosylaminoimidazole carboxylase activity;phosphoribosylaminoimidazolesuccinocarboxamide synthase activity","cytoplasm;cytosol;extracellular exosome;membrane","Metabolic pathways;Purine metabolism",null,null,21,21,21,64,64,64,"47.079",0,"321.91",5559100000,183,"0.133057",1,"0.114627","0.386911","sp|P22234|PUR6_HUMAN;tr|E9PBS1|E9PBS1_HUMAN;tr|D6RF62|D6RF62_HUMAN","sp|P22234|PUR6_HUMAN;tr|E9PBS1|E9PBS1_HUMAN;tr|D6RF62|D6RF62_HUMAN",1179,"P22234","PUR6_HUMAN","Multifunctional protein ADE2",null,"PAICS"]
["20.6057","21.188","21.0317","20.5329",{"$nulls":3},"iron-sulfur cluster assembly;protein maturation by iron-sulfur cluster transfer;small molecule metabolic process","2 iron, 2 sulfur cluster binding;ferrous iron binding;structural molecule activity","mitochondrial matrix",{"$nulls":3},4,4,4,"41.9","41.9","41.9","14.179",0,"15.24",109300000,18,"0.10053",1,"0.11451","0.29868","sp|Q9BUE6|ISCA1_HUMAN;tr|Q5TBE2|Q5TBE2_HUMAN;tr|Q5TBE9|Q5TBE9_HUMAN","sp|Q9BUE6|ISCA1_HUMAN",3983,"Q9BUE6","ISCA1_HUMAN","Iron-sulfur cluster assembly 1 homolog, mitochondrial",null,"ISCA1"]
["19.4059","19.7935","19.6769","19.2943",{"$nulls":3},"[2Fe-2S] cluster assembly;iron incorporation into metallo-sulfur cluster;molybdopterin cofactor biosynthetic process;Mo-molybdopterin cofactor biosynthetic process;protein complex assembly;small molecule metabolic process;sulfur amino acid metabolic process","cysteine desulfurase activity;iron-sulfur cluster binding;metal ion binding;protein homodimerization activity;pyridoxal phosphate binding","cytosol;mitochondrial matrix;mitochondrion;nucleoplasm;nucleus","Metabolic pathways;Sulfur relay system;Thiamine metabolism",null,null,5,5,5,"14.9","14.9","14.9","50.195",0,"22.492",192120000,15,"0.145137",1,"0.114088","0.419017","sp|Q9Y697|NFS1_HUMAN;tr|F2Z2E7|F2Z2E7_HUMAN;tr|H7C0I5|H7C0I5_HUMAN;tr|H0YGN5|H0YGN5_HUMAN;tr|F8WER8|F8WER8_HUMAN;tr|A2A2M1|A2A2M1_HUMAN;tr|F8WB23|F8WB23_HUMAN;tr|Q8WV90|Q8WV90_HUMAN","sp|Q9Y697|NFS1_HUMAN;tr|F2Z2E7|F2Z2E7_HUMAN",5082,"Q9Y697","NFS1_HUMAN","Cysteine desulfurase, mitochondrial",null,"NFS1"]
["19.0255","19.404","19.2782","18.9239",{"$nulls":3},"anterograde axonal transport;antigen processing and presentation of exogenous peptide antigen via MHC class II;microtubule-based movement;mitotic cytokinesis;mitotic spindle midzone assembly;organelle organization;retrograde vesicle-mediated transport, Golgi to ER","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;DNA binding;microtubule binding;microtubule motor activity","axon cytoplasm;chromosome;cytoplasm;cytosol;intercellular bridge;kinesin complex;membrane;midbody;nuclear matrix;nucleoplasm;spindle microtubule",{"$nulls":3},17,17,16,"17.1","17.1","16.2","139.88",0,"75.149",417100000,62,"0.152517",1,"0.113667","0.438481","sp|O95239|KIF4A_HUMAN;sp|Q2VIQ3|KIF4B_HUMAN;tr|Q5JRK0|Q5JRK0_HUMAN","sp|O95239|KIF4A_HUMAN",706,"O95239","KIF4A_HUMAN","Chromosome-associated kinesin KIF4A",null,"KIF4A"]
["14.6481","13.5625","14.5864","13.3981",{"$nulls":4},"DNA binding transcription factor activity","transcription elongation factor complex","Transcriptional misregulation in cancer",null,null,7,7,7,"7.8","7.8","7.8","131.42",0,"17.953",121890000,19,"0.0451895",1,"0.113026","0.140443","sp|P51825|AFF1_HUMAN;tr|F5GXF9|F5GXF9_HUMAN;tr|E7ETI4|E7ETI4_HUMAN;tr|E7EMC5|E7EMC5_HUMAN","sp|P51825|AFF1_HUMAN;tr|F5GXF9|F5GXF9_HUMAN",1669,"P51825","AFF1_HUMAN","AF4/FMR2 family member 1",null,"AFF1"]
["17.43","19.2774","18.1792","18.3055",{"$nulls":4},"RNA binding",{"$nulls":4},11,11,11,"22.5","22.5","22.5","69.437",0,"64.935",459890000,63,"0.0384767",1,"0.111413","0.120337","sp|Q86U38|NOP9_HUMAN","sp|Q86U38|NOP9_HUMAN",3040,"Q86U38","NOP9_HUMAN","Nucleolar protein 9",null,"NOP9"]
["20.7724","21.0699","20.9388","20.6811",{"$nulls":4},"RNA binding",{"$nulls":4},5,1,1,"37.7","9.4","9.4","32.035",0,"45.513",170740000,15,"0.201442",1,"0.111224","0.565231","tr|F8VRH0|F8VRH0_HUMAN","tr|F8VRH0|F8VRH0_HUMAN",5228,"F8VRH0","F8VRH0_HUMAN",null,null,"PCBP2"]
[1,"21.3611",1,"21.1423",{"$nulls":3},"transcription initiation from RNA polymerase II promoter",null,"transcription factor TFIIA complex",{"$nulls":3},1,1,1,"13.2","13.2","13.2","7.7969","0.0061815","2.6404",26682000,1,"0.00235217",1,"0.109391","0.00763889","tr|A8MYR4|A8MYR4_HUMAN;tr|H0YK39|H0YK39_HUMAN;sp|P52657|T2AG_HUMAN","tr|A8MYR4|A8MYR4_HUMAN;tr|H0YK39|H0YK39_HUMAN;sp|P52657|T2AG_HUMAN",1691,"A8MYR4","A8MYR4_HUMAN",null,null,"GTF2A2"]
["25.475","25.5449","25.5378","25.2634",{"$nulls":3},"glutathione metabolic process;response to virus;translational elongation","cadherin binding;glutathione transferase activity;translation elongation factor activity","cytoplasm;cytosol;extracellular exosome;membrane;nucleus","Legionellosis",null,null,24,24,24,"69.8","69.8","69.8","50.118",0,"323.31",10172000000,352,"0.283453",1,"0.109353","0.772428","sp|P26641|EF1G_HUMAN","sp|P26641|EF1G_HUMAN",1245,"P26641","EF1G_HUMAN","Elongation factor 1-gamma","F-1-gamma","EEF1G"]
["21.4963","22.6502","22.4239","21.5075",{"$nulls":3},"signal transduction","GTP binding;GTPase activity","membrane",{"$nulls":3},5,5,5,"65.8","65.8","65.8","8.6739",0,"28.333",273280000,30,"0.0470455",1,"0.107537","0.145962","tr|C9J931|C9J931_HUMAN;sp|Q15382|RHEB_HUMAN;tr|C9J469|C9J469_HUMAN","tr|C9J931|C9J931_HUMAN;sp|Q15382|RHEB_HUMAN",2479,"C9J931","C9J931_HUMAN",null,null,"RHEB"]
["18.5465","18.7112","18.4756","18.5692",{"$nulls":3},"behavioral fear response;cell adhesion;endothelial cell migration;locomotory exploration behavior;negative regulation of extracellular matrix disassembly;positive regulation of cell proliferation;proteolysis;psychomotor behavior;regulation of cell-cell adhesion mediated by integrin;regulation of insulin secretion;response to hypoxia;T cell activation;T cell costimulation","dipeptidyl-peptidase activity;identical protein binding;protease binding;protein homodimerization activity;receptor binding;serine-type endopeptidase activity;serine-type peptidase activity;virus receptor activity","apical plasma membrane;cell surface;endocytic vesicle;extracellular exosome;extracellular region;focal adhesion;integral component of membrane;intercellular canaliculus;invadopodium membrane;lamellipodium;lamellipodium membrane;lysosomal membrane;membrane;membrane raft;plasma membrane","Protein digestion and absorption",null,null,7,7,7,"10.4","10.4","10.4","88.278",0,"10.974",121680000,13,"0.422631",1,"0.106445","1.12371","sp|P27487|DPP4_HUMAN;tr|H7C1N5|H7C1N5_HUMAN;tr|F8WBB6|F8WBB6_HUMAN;tr|F8WE17|F8WE17_HUMAN","sp|P27487|DPP4_HUMAN",1251,"P27487","DPP4_HUMAN","Dipeptidyl peptidase 4",null,"DPP4"]
["20.5971","20.5109","20.7062","20.1917",{"$nulls":5},"R2TP complex",{"$nulls":3},16,16,16,"30.1","30.1","30.1","75.718",0,"76.384",915860000,100,"0.139099",1,"0.105107","0.403009","sp|Q9H6T3|RPAP3_HUMAN","sp|Q9H6T3|RPAP3_HUMAN",4232,"Q9H6T3","RPAP3_HUMAN","RNA polymerase II-associated protein 3",null,"RPAP3"]
["18.6188","19.1924","18.9167","18.6845",{"$nulls":3},"endocytic recycling","metal ion binding;Rab GTPase binding","intracellular",{"$nulls":3},1,1,1,10,10,10,"22.149","0.009977","2.1971",16244000,3,"0.115402",1,"0.104996","0.339373","tr|B0QY86|B0QY86_HUMAN;sp|Q8N3F8|MILK1_HUMAN","tr|B0QY86|B0QY86_HUMAN;sp|Q8N3F8|MILK1_HUMAN",3216,"B0QY86","B0QY86_HUMAN",null,null,"MICALL1"]
["27.6562","27.4067","27.4399","27.414",{"$nulls":3},"cell aging;cellular response to UV;CENP-A containing nucleosome assembly;centrosome cycle;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA repair;intracellular protein transport;negative regulation of apoptotic process;negative regulation of cell proliferation;negative regulation of centrosome duplication;negative regulation of protein kinase activity by regulation of protein phosphorylation;nucleocytoplasmic transport;nucleosome assembly;positive regulation of cell cycle G2/M phase transition;positive regulation of cell proliferation;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of translation;protein localization;protein oligomerization;regulation of centriole replication;regulation of eIF2 alpha phosphorylation by dsRNA;regulation of endodeoxyribonuclease activity;regulation of endoribonuclease activity;regulation of transcription from RNA polymerase II promoter;response to stress;ribosome assembly;signal transduction;viral process","activating transcription factor binding;core promoter binding;histone binding;NF-kappaB binding;protein heterodimerization activity;protein homodimerization activity;protein kinase binding;protein kinase inhibitor activity;ribosomal large subunit binding;ribosomal small subunit binding;RNA binding;RNA polymerase II transcription coactivator activity;Tat protein binding;transcription coactivator activity;transcription factor binding;unfolded protein binding","centrosome;cytoplasm;cytosol;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;spindle pole centrosome",{"$nulls":3},12,12,12,"44.2","44.2","44.2","32.575",0,"323.31",22391000000,242,"0.307496",1,"0.104437","0.832705","sp|P06748|NPM_HUMAN;tr|E5RGW4|E5RGW4_HUMAN;tr|E5RI98|E5RI98_HUMAN","sp|P06748|NPM_HUMAN",883,"P06748","NPM_HUMAN","Nucleophosmin","PM","NPM1"]
["27.0493","27.1599","27.3583","26.6433",{"$nulls":3},"erythrocyte differentiation;maturation of SSU-rRNA;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);negative regulation of transcription from RNA polymerase II promoter;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","mRNA 5'-UTR binding;RNA binding;small ribosomal subunit rRNA binding;structural constituent of ribosome;translation regulator activity","cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;mitochondrion;nucleolus;nucleoplasm","Ribosome",null,null,10,10,10,"66.9","66.9","66.9","16.273",0,"320.2",42150000000,1157,"0.0962823",1,"0.103788","0.286936","sp|P62263|RS14_HUMAN;tr|E5RH77|E5RH77_HUMAN;tr|H0YB22|H0YB22_HUMAN","sp|P62263|RS14_HUMAN;tr|E5RH77|E5RH77_HUMAN;tr|H0YB22|H0YB22_HUMAN",1881,"P62263","RS14_HUMAN","40S ribosomal protein S14",null,"RPS14"]
["18.6517","15.7953","18.6094","15.6313",{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;intracellular protein transport",null,"AP-type membrane coat adaptor complex;axon cytoplasm;clathrin adaptor complex;cytoplasmic vesicle membrane;Golgi apparatus","Lysosome",null,null,10,7,7,"37.1","29.9","29.9","46.977",0,"53.654",477320000,26,"0.0156239",1,"0.10317","0.0500038","sp|P53677|AP3M2_HUMAN;tr|E5RJ52|E5RJ52_HUMAN;tr|E7ER80|E7ER80_HUMAN;tr|H0YBA0|H0YBA0_HUMAN;tr|H0YBM0|H0YBM0_HUMAN;tr|H0YAY4|H0YAY4_HUMAN;tr|E5RI83|E5RI83_HUMAN","sp|P53677|AP3M2_HUMAN;tr|E5RJ52|E5RJ52_HUMAN;tr|E7ER80|E7ER80_HUMAN",1721,"P53677","AP3M2_HUMAN","AP-3 complex subunit mu-2",null,"AP3M2"]
["25.9212","26.2404","26.045","25.9106",{"$nulls":3},"fibroblast growth factor receptor signaling pathway;IRES-dependent viral translational initiation;mRNA processing;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;negative regulation of muscle cell differentiation;negative regulation of RNA splicing;regulation of alternative mRNA splicing, via spliceosome;RNA metabolic process;RNA splicing","poly-pyrimidine tract binding;pre-mRNA binding;RNA binding","extracellular exosome;membrane;nucleolus;nucleoplasm",{"$nulls":3},20,20,17,"59.3","59.3","54.6","57.221",0,"323.31",11328000000,207,"0.212963",1,"0.102968","0.594627","sp|P26599|PTBP1_HUMAN;tr|A6NLN1|A6NLN1_HUMAN;tr|A0A0D9SF20|A0A0D9SF20_HUMAN;tr|K7EKJ7|K7EKJ7_HUMAN;tr|K7EK45|K7EK45_HUMAN;tr|K7ES59|K7ES59_HUMAN;tr|A0A087WU68|A0A087WU68_HUMAN;tr|K7ELW5|K7ELW5_HUMAN;tr|A0A087WUW5|A0A087WUW5_HUMAN","sp|P26599|PTBP1_HUMAN;tr|A6NLN1|A6NLN1_HUMAN",1242,"P26599","PTBP1_HUMAN","Polypyrimidine tract-binding protein 1","TB","PTBP1"]
["20.1079","20.035","20.4099","19.5292",{"$nulls":3},"endocytosis;membrane organization;regulation of protein transport;signal transduction","cadherin binding;GTPase activating protein binding;GTPase activator activity;guanyl-nucleotide exchange factor activity;Rab guanyl-nucleotide exchange factor activity","cytosol;endosome;membrane",{"$nulls":3},20,20,20,"17.5","17.5","17.5","164.98",0,"62.918",608640000,60,"0.0762111",1,"0.101899","0.230621","sp|Q14C86|GAPD1_HUMAN;tr|F8W9S7|F8W9S7_HUMAN;tr|C9IZ08|C9IZ08_HUMAN;tr|B4DGD8|B4DGD8_HUMAN;tr|B0QZ65|B0QZ65_HUMAN;tr|H0Y7I9|H0Y7I9_HUMAN;tr|A0A0A0MQV8|A0A0A0MQV8_HUMAN;tr|H0Y4E7|H0Y4E7_HUMAN;tr|C9IZX9|C9IZX9_HUMAN","sp|Q14C86|GAPD1_HUMAN;tr|F8W9S7|F8W9S7_HUMAN;tr|C9IZ08|C9IZ08_HUMAN;tr|B4DGD8|B4DGD8_HUMAN;tr|B0QZ65|B0QZ65_HUMAN",2411,"Q14C86","GAPD1_HUMAN","GTPase-activating protein and VPS9 domain-containing protein 1",null,"GAPVD1"]
["19.4761","19.1879","19.5612","18.9008",{"$nulls":9},4,4,4,"31.7","31.7","31.7","17.799",0,"10.85",81070000,16,"0.0938601",1,"0.100951","0.280213","tr|M0QYT5|M0QYT5_HUMAN;sp|Q9NZ43|USE1_HUMAN;tr|G8JLK1|G8JLK1_HUMAN;tr|M0QZE0|M0QZE0_HUMAN","tr|M0QYT5|M0QYT5_HUMAN;sp|Q9NZ43|USE1_HUMAN;tr|G8JLK1|G8JLK1_HUMAN;tr|M0QZE0|M0QZE0_HUMAN",4583,"M0QYT5","M0QYT5_HUMAN",null,null,"USE1"]
["20.5291","20.9365","20.6884","20.5783",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear mRNA surveillance;nuclear polyadenylation-dependent mRNA catabolic process;nuclear polyadenylation-dependent rRNA catabolic process;nuclear polyadenylation-dependent tRNA catabolic process;nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';regulation of mRNA stability;rRNA processing;U1 snRNA 3'-end processing;U4 snRNA 3'-end processing;U5 snRNA 3'-end processing","AU-rich element binding;identical protein binding","cytoplasm;cytoplasmic exosome (RNase complex);cytosol;exosome (RNase complex);nuclear exosome (RNase complex);nucleolus;nucleoplasm;nucleus","RNA degradation",null,null,4,4,4,"24.6","24.6","24.6","30.039",0,"25.174",168040000,13,"0.164995",1,"0.0994186","0.471161","sp|Q96B26|EXOS8_HUMAN","sp|Q96B26|EXOS8_HUMAN",3609,"Q96B26","EXOS8_HUMAN","Exosome complex component RRP43",null,"EXOSC8"]
["24.4837","24.7635","24.7532","24.2979",{"$nulls":3},"gene silencing by RNA;mRNA polyadenylation;mRNA splicing, via spliceosome;mRNA stabilization;negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of viral genome replication;regulation of mRNA stability;translational initiation","mRNA 3'-UTR binding;poly(A) binding;poly(U) RNA binding;protein C-terminus binding;RNA binding;translation activator activity","catalytic step 2 spliceosome;cytoplasm;cytoplasmic ribonucleoprotein granule;cytoplasmic stress granule;cytosol;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleus","mRNA surveillance pathway;RNA degradation;RNA transport",null,null,29,29,19,"56.8","56.8","37.7","70.67",0,"323.31",7954600000,280,"0.125615",1,"0.0980644","0.366968","sp|P11940|PABP1_HUMAN;tr|A0A087WTT1|A0A087WTT1_HUMAN;tr|E7EQV3|E7EQV3_HUMAN;tr|E7ERJ7|E7ERJ7_HUMAN;tr|H0YAR2|H0YAR2_HUMAN;sp|Q9H361|PABP3_HUMAN;tr|H0YBN4|H0YBN4_HUMAN;tr|E5RJB9|E5RJB9_HUMAN;tr|H0YAP2|H0YAP2_HUMAN;tr|E5RGH3|E5RGH3_HUMAN;tr|E5RH24|E5RH24_HUMAN;tr|H0YAS6|H0YAS6_HUMAN;tr|H0YB75|H0YB75_HUMAN;tr|H0YAS7|H0YAS7_HUMAN;tr|H0YB86|H0YB86_HUMAN;sp|Q4VXU2|PAP1L_HUMAN;tr|E5RHG7|E5RHG7_HUMAN;tr|H0YC10|H0YC10_HUMAN;tr|E5RGC4|E5RGC4_HUMAN;tr|E5RFD8|E5RFD8_HUMAN;tr|E5RJM8|E5RJM8_HUMAN;tr|H0YAW6|H0YAW6_HUMAN;sp|Q96DU9|PABP5_HUMAN","sp|P11940|PABP1_HUMAN;tr|A0A087WTT1|A0A087WTT1_HUMAN;tr|E7EQV3|E7EQV3_HUMAN;tr|E7ERJ7|E7ERJ7_HUMAN",1005,"P11940","PABP1_HUMAN","Polyadenylate-binding protein 1","ABP-1;oly(A)-binding protein 1","PABPC1"]
["27.0032","27.6865","27.3069","27.1883",{"$nulls":3},"activation of MAPK activity;anaphase-promoting complex-dependent catabolic process;cellular iron ion homeostasis;cellular protein metabolic process;DNA damage response, detection of DNA damage;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;endoplasmic reticulum mannose trimming;endosomal transport;entry of bacterium into host cell;ERBB2 signaling pathway;error-free translesion synthesis;error-prone translesion synthesis;Fc-epsilon receptor signaling pathway;fibroblast growth factor receptor signaling pathway;G2/M transition of mitotic cell cycle;global genome nucleotide-excision repair;glycogen biosynthetic process;I-kappaB kinase/NF-kappaB signaling;innate immune response;interstrand cross-link repair;intracellular transport of virus;ion transmembrane transport;JNK cascade;macroautophagy;MAPK cascade;membrane organization;MyD88-dependent toll-like receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway;negative regulation of apoptotic process;negative regulation of canonical Wnt signaling pathway;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transforming growth factor beta receptor signaling pathway;negative regulation of type I interferon production;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;Notch signaling pathway;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleotide-binding oligomerization domain containing signaling pathway;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;positive regulation of apoptotic process;positive regulation of canonical Wnt signaling pathway;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein folding;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of necroptotic process;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter in response to hypoxia;regulation of tumor necrosis factor-mediated signaling pathway;regulation of type I interferon production;rRNA processing;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;SRP-dependent cotranslational protein targeting to membrane;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;transcription-coupled nucleotide-excision repair;transforming growth factor beta receptor signaling pathway;translation;translational initiation;translesion synthesis;transmembrane transport;TRIF-dependent toll-like receptor signaling pathway;tumor necrosis factor-mediated signaling pathway;viral life cycle;viral transcription;virion assembly;Wnt signaling pathway;Wnt signaling pathway, planar cell polarity pathway","metal ion binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic small ribosomal subunit;endocytic vesicle membrane;endoplasmic reticulum membrane;endoplasmic reticulum quality control compartment;endosome membrane;extracellular exosome;extracellular space;host cell;membrane;mitochondrial outer membrane;myelin sheath;nucleolus;nucleoplasm;nucleus;plasma membrane;small ribosomal subunit;vesicle","Ribosome",null,null,7,7,2,"51.9","51.9","20.5","17.965",0,"89.397",11710000000,268,"0.0939803",1,"0.0972691","0.280547","sp|P62979|RS27A_HUMAN;tr|J3QS39|J3QS39_HUMAN;tr|J3QTR3|J3QTR3_HUMAN;tr|F5H6Q2|F5H6Q2_HUMAN;tr|F5GYU3|F5GYU3_HUMAN;tr|F5H2Z3|F5H2Z3_HUMAN;tr|F5H265|F5H265_HUMAN;tr|B4DV12|B4DV12_HUMAN;tr|F5H388|F5H388_HUMAN;tr|F5H747|F5H747_HUMAN;tr|F5GXK7|F5GXK7_HUMAN;tr|J3QKN0|J3QKN0_HUMAN;tr|Q5PY61|Q5PY61_HUMAN;sp|P0CG47|UBB_HUMAN;tr|Q96C32|Q96C32_HUMAN;sp|P0CG48|UBC_HUMAN;tr|M0R1V7|M0R1V7_HUMAN;tr|M0R1M6|M0R1M6_HUMAN;tr|J3QLP7|J3QLP7_HUMAN;tr|J3QRK5|J3QRK5_HUMAN;tr|J3QSA3|J3QSA3_HUMAN;tr|K7EMA8|K7EMA8_HUMAN;tr|F5GZ39|F5GZ39_HUMAN;tr|J3KSM4|J3KSM4_HUMAN","sp|P62979|RS27A_HUMAN;tr|J3QS39|J3QS39_HUMAN;tr|J3QTR3|J3QTR3_HUMAN;tr|F5H6Q2|F5H6Q2_HUMAN;tr|F5GYU3|F5GYU3_HUMAN;tr|F5H2Z3|F5H2Z3_HUMAN;tr|F5H265|F5H265_HUMAN;tr|B4DV12|B4DV12_HUMAN;tr|F5H388|F5H388_HUMAN;tr|F5H747|F5H747_HUMAN;tr|F5GXK7|F5GXK7_HUMAN;tr|J3QKN0|J3QKN0_HUMAN;tr|Q5PY61|Q5PY61_HUMAN;sp|P0CG47|UBB_HUMAN;tr|Q96C32|Q96C32_HUMAN;sp|P0CG48|UBC_HUMAN;tr|M0R1V7|M0R1V7_HUMAN;tr|M0R1M6|M0R1M6_HUMAN",1931,"P62979","RS27A_HUMAN","Ubiquitin-40S ribosomal protein S27a",null,"RPS27A"]
["20.6775","21.7635","21.1087","21.1388",{"$nulls":3},"transmembrane transport",null,"integral component of membrane",{"$nulls":3},8,8,8,"33.5","33.5","33.5","33.281",0,"63.12",656250000,63,"0.05795",1,"0.0967226","0.178052","tr|E9PJH7|E9PJH7_HUMAN;sp|Q9H936|GHC1_HUMAN;tr|A0A0D9SFE1|A0A0D9SFE1_HUMAN;tr|A0A0D9SEI9|A0A0D9SEI9_HUMAN;tr|K4DIB8|K4DIB8_HUMAN;tr|K4DIA8|K4DIA8_HUMAN;tr|E9PS95|E9PS95_HUMAN;sp|Q9H1K4|GHC2_HUMAN;tr|K4DIB6|K4DIB6_HUMAN;tr|K4DIB3|K4DIB3_HUMAN;tr|A0A0D9SFA8|A0A0D9SFA8_HUMAN;tr|K4DIB0|K4DIB0_HUMAN;tr|K4DIA2|K4DIA2_HUMAN;tr|A0A0D9SG84|A0A0D9SG84_HUMAN;tr|E9PI74|E9PI74_HUMAN;tr|E9PQ36|E9PQ36_HUMAN","tr|E9PJH7|E9PJH7_HUMAN;sp|Q9H936|GHC1_HUMAN;tr|A0A0D9SFE1|A0A0D9SFE1_HUMAN;tr|A0A0D9SEI9|A0A0D9SEI9_HUMAN;tr|K4DIB8|K4DIB8_HUMAN;tr|K4DIA8|K4DIA8_HUMAN;tr|E9PS95|E9PS95_HUMAN;sp|Q9H1K4|GHC2_HUMAN",4266,"E9PJH7","E9PJH7_HUMAN",null,null,"SLC25A22"]
["17.549","16.6137","17.6823","16.2879",{"$nulls":3},"autophagy;negative regulation of clathrin-dependent endocytosis;negative regulation of G-protein coupled receptor internalization;positive regulation of ER-associated ubiquitin-dependent protein catabolic process;regulation of autophagosome assembly;regulation of macroautophagy;ubiquitin-dependent ERAD pathway",null,"autophagosome;cytoplasm;cytoplasmic vesicle;cytosol;nucleus;plasma membrane","Protein processing in endoplasmic reticulum",null,null,1,1,1,"2.6","2.6","2.6","65.695","0.00026089","7.2533",23064000,8,"0.0365955",1,"0.096261","0.11466","sp|Q9UHD9|UBQL2_HUMAN","sp|Q9UHD9|UBQL2_HUMAN",4724,"Q9UHD9","UBQL2_HUMAN","Ubiquilin-2",null,"UBQLN2"]
["21.176","20.878","21.2343","20.6281",{"$nulls":3},"cell growth;endoplasmic reticulum organization;IRE1-mediated unfolded protein response;posttranslational protein targeting to endoplasmic reticulum membrane;pronephric nephron development;protein targeting to ER;response to interferon-gamma;SRP-dependent cotranslational protein targeting to membrane","ribosome binding","cytosol;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane;rough endoplasmic reticulum","Phagosome;Protein export;Protein processing in endoplasmic reticulum;Vibrio cholerae infection",null,null,7,7,7,"14.9","14.9","14.9","52.264",0,"61.131",432320000,48,"0.0950658",1,"0.0957727","0.283562","sp|P61619|S61A1_HUMAN;tr|B4DR61|B4DR61_HUMAN;tr|H7C1Q9|H7C1Q9_HUMAN;tr|C9JXC6|C9JXC6_HUMAN;tr|H7C069|H7C069_HUMAN;tr|A6NK38|A6NK38_HUMAN;tr|F2Z2C7|F2Z2C7_HUMAN;tr|A6NIF9|A6NIF9_HUMAN;tr|C9JJV4|C9JJV4_HUMAN;tr|F8W776|F8W776_HUMAN;tr|Q8TC24|Q8TC24_HUMAN;sp|Q9H9S3|S61A2_HUMAN","sp|P61619|S61A1_HUMAN;tr|B4DR61|B4DR61_HUMAN",1851,"P61619","S61A1_HUMAN","Protein transport protein Sec61 subunit alpha isoform 1","ec61 alpha-1","SEC61A1"]
["22.5659","22.1432","22.4894","22.0293",{"$nulls":3},"positive regulation of apoptotic process;protein localization to mitochondrion",null,"extracellular exosome;integral component of membrane;membrane;mitochondrial inner membrane;mitochondrion;nucleus",{"$nulls":3},8,8,2,37,37,"9.2","33.331",0,"71.997",700840000,99,"0.102692",1,"0.09517","0.304637","sp|Q9Y6C9|MTCH2_HUMAN","sp|Q9Y6C9|MTCH2_HUMAN",5087,"Q9Y6C9","MTCH2_HUMAN","Mitochondrial carrier homolog 2",null,"MTCH2"]
["23.4247","23.7719","23.6472","23.3615",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process;cellular response to aldosterone;cellular response to estradiol stimulus;cellular response to hydrogen peroxide;cellular response to nitric oxide;cellular response to oxygen-glucose deprivation;chromosome condensation;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;mitochondrial respiratory chain complex I assembly;neuron apoptotic process;neuron differentiation;positive regulation of apoptotic process;positive regulation of neuron apoptotic process;regulation of apoptotic DNA fragmentation;response to ischemia;response to L-glutamate;response to toxic substance","DNA binding;FAD binding;NAD(P)H oxidase activity;oxidoreductase activity, acting on NAD(P)H;protein dimerization activity","cytosol;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrion;nucleus;perinuclear region of cytoplasm","Apoptosis;Necroptosis",null,null,22,22,22,"48.8","48.8","48.8","66.9",0,"187.22",3803700000,216,"0.144719",1,"0.0939703","0.417912","sp|O95831|AIFM1_HUMAN;tr|E9PMA0|E9PMA0_HUMAN","sp|O95831|AIFM1_HUMAN;tr|E9PMA0|E9PMA0_HUMAN",771,"O95831","AIFM1_HUMAN","Apoptosis-inducing factor 1, mitochondrial",null,"AIFM1"]
["15.258","14.8333","15.6056","14.2993",{"$nulls":3},"cellular response to hydroxyurea;chromatin remodeling;chromosome organization involved in meiotic cell cycle;covalent chromatin modification;DNA damage response, signal transduction by p53 class mediator;DNA methylation;DNA recombination;DNA repair;DNA replication-independent nucleosome assembly;forebrain development;meiotic spindle organization;multicellular organism growth;negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric;negative regulation of telomeric RNA transcription from RNA pol II promoter;nucleosome assembly;positive regulation of nuclear cell cycle DNA replication;positive regulation of telomere maintenance;positive regulation of telomeric RNA transcription from RNA pol II promoter;positive regulation of transcription from RNA polymerase II promoter;post-embryonic forelimb morphogenesis;protein localization to chromosome, telomeric region;regulation of histone H3-K9 trimethylation;regulation of transcription, DNA-templated;replication fork processing;seminiferous tubule development;Sertoli cell development;spermatogenesis;transcription, DNA-templated","ATP binding;chromatin binding;chromo shadow domain binding;DNA binding;DNA helicase activity;DNA translocase activity;helicase activity;histone binding;metal ion binding;methylated histone binding","condensed nuclear chromosome, centromeric region;nuclear body;nuclear chromosome, telomeric region;nuclear heterochromatin;nuclear pericentric heterochromatin;nuclear subtelomeric heterochromatin;nucleoplasm;nucleus;pericentric heterochromatin;PML body;SWI/SNF superfamily-type complex;telomeric heterochromatin",{"$nulls":3},27,27,27,"13.4","13.4","13.4","282.58",0,"89.728",640380000,127,"0.0436042",1,"0.0932088","0.135716","sp|P46100|ATRX_HUMAN;tr|A0A096LNL9|A0A096LNL9_HUMAN;tr|A0A096LNW1|A0A096LNW1_HUMAN;tr|A0A096LNN3|A0A096LNN3_HUMAN;tr|A0A087WWG0|A0A087WWG0_HUMAN;tr|A0A096LNX6|A0A096LNX6_HUMAN;tr|H0Y3T0|H0Y3T0_HUMAN;tr|A0A096LPG6|A0A096LPG6_HUMAN;tr|A0A096LNL6|A0A096LNL6_HUMAN;tr|A0A096LP59|A0A096LP59_HUMAN","sp|P46100|ATRX_HUMAN",1505,"P46100","ATRX_HUMAN","Transcriptional regulator ATRX",null,"ATRX"]
["21.9776","21.9638","22.26","21.4958",{"$nulls":4},"RNA binding","mRNA cleavage factor complex;nuclear speck;nucleoplasm",{"$nulls":3},6,6,6,18,18,18,"52.269",0,"66.75",740450000,60,"0.0805739",1,"0.0928621","0.242984","tr|F8WJN3|F8WJN3_HUMAN;sp|Q16630|CPSF6_HUMAN;tr|F8W084|F8W084_HUMAN","tr|F8WJN3|F8WJN3_HUMAN;sp|Q16630|CPSF6_HUMAN",2558,"F8WJN3","F8WJN3_HUMAN",null,null,"CPSF6"]
["19.7118","19.7221","19.9948","19.2536",{"$nulls":4},"nucleic acid binding","nucleus",{"$nulls":3},3,3,3,"11.7","11.7","11.7","41.364",0,"15.97",192880000,26,"0.083147",1,"0.0927496","0.250243","tr|C9JZE3|C9JZE3_HUMAN;tr|C9JYJ8|C9JYJ8_HUMAN;sp|Q9BWE0|REPI1_HUMAN;tr|E7EVL6|E7EVL6_HUMAN","tr|C9JZE3|C9JZE3_HUMAN;tr|C9JYJ8|C9JYJ8_HUMAN;sp|Q9BWE0|REPI1_HUMAN;tr|E7EVL6|E7EVL6_HUMAN",4030,"C9JZE3","C9JZE3_HUMAN",null,null,"REPIN1"]
["22.2016","22.2171","22.5448","21.691",{"$nulls":3},"isoleucyl-tRNA aminoacylation;tRNA aminoacylation for protein translation","aminoacyl-tRNA editing activity;ATP binding;isoleucine-tRNA ligase activity;tRNA binding","cytosol;mitochondrial matrix;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,24,24,24,"30.7","30.7","30.7","113.79",0,"147.79",1532500000,107,"0.0704738",1,"0.0914783","0.214252","sp|Q9NSE4|SYIM_HUMAN","sp|Q9NSE4|SYIM_HUMAN",4442,"Q9NSE4","SYIM_HUMAN","Isoleucine--tRNA ligase, mitochondrial",null,"IARS2"]
["23.3932",1,"23.2121",1,{"$nulls":9},1,1,1,"29.7","29.7","29.7","7.0202",0,"15.733",82449000,2,"0.00176701",1,"0.09056","0.00574237","tr|B8ZZF8|B8ZZF8_HUMAN;sp|Q9Y4Y9|LSM5_HUMAN","tr|B8ZZF8|B8ZZF8_HUMAN;sp|Q9Y4Y9|LSM5_HUMAN",5025,"B8ZZF8","B8ZZF8_HUMAN",null,null,"LSM5"]
["23.899","24.6494","24.2266","24.143",{"$nulls":3},"carbohydrate metabolic process;protein folding","carbohydrate binding;glucan 1,3-alpha-glucosidase activity;RNA binding","endoplasmic reticulum lumen;extracellular exosome;extracellular matrix;glucosidase II complex;Golgi apparatus;melanosome;membrane","Metabolic pathways;N-Glycan biosynthesis;Protein processing in endoplasmic reticulum",null,null,42,42,8,"52.9","52.9","10.5","106.87",0,"323.31",7437300000,395,"0.0784113",1,"0.0894232","0.236865","sp|Q14697|GANAB_HUMAN;tr|F5H6X6|F5H6X6_HUMAN","sp|Q14697|GANAB_HUMAN;tr|F5H6X6|F5H6X6_HUMAN",2389,"Q14697","GANAB_HUMAN","Neutral alpha-glucosidase AB",null,"GANAB"]
["20.9008","19.9228","21.2873","19.3583",{"$nulls":3},"acylglycerol catabolic process;adult walking behavior;glycerophospholipid catabolic process;monoacylglycerol catabolic process;phosphatidylserine catabolic process;protein depalmitoylation;response to auditory stimulus","acylglycerol lipase activity;lysophospholipase activity;palmitoyl-(protein) hydrolase activity","AMPA glutamate receptor complex;dendrite cytoplasm;integral component of membrane;plasma membrane",{"$nulls":3},11,11,11,"35.4","35.4","35.4","45.096",0,"68.904",647510000,61,"0.0260031",1,"0.0890265","0.0823291","sp|Q8N2K0|ABD12_HUMAN;tr|I3L294|I3L294_HUMAN;tr|Q5T712|Q5T712_HUMAN;tr|I3L440|I3L440_HUMAN;tr|I3L1V0|I3L1V0_HUMAN;tr|I3L380|I3L380_HUMAN","sp|Q8N2K0|ABD12_HUMAN",3208,"Q8N2K0","ABD12_HUMAN","Monoacylglycerol lipase ABHD12 {ECO:0000305}",null,"ABHD12"]
["17.0692","17.9072","17.7754","17.0253",{"$nulls":3},"cell division;chromosome segregation;establishment of spindle orientation;mitotic sister chromatid segregation;positive regulation of intracellular transport;positive regulation of spindle assembly;protein localization to centrosome;regulation of attachment of spindle microtubules to kinetochore;regulation of metaphase plate congression;spindle organization","microtubule binding","centriolar satellite;condensed chromosome kinetochore;cytoplasm;kinetochore;microtubule plus-end;midbody;mitotic spindle;mitotic spindle pole;spindle microtubule",{"$nulls":3},5,5,5,"6.4","6.4","6.4","134.42",0,"14.841",253550000,32,"0.0505048",1,"0.0878391","0.156203","sp|Q96R06|SPAG5_HUMAN;tr|K7ELC8|K7ELC8_HUMAN;tr|E9PMD0|E9PMD0_HUMAN;tr|J3KTQ0|J3KTQ0_HUMAN","sp|Q96R06|SPAG5_HUMAN",3800,"Q96R06","SPAG5_HUMAN","Sperm-associated antigen 5",null,"SPAG5"]
["26.7397","27.2965","26.9792","26.8832",{"$nulls":3},"chaperone-mediated autophagy;chaperone-mediated protein complex assembly;ciliary basal body-plasma membrane docking;ERBB2 signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;G2/M transition of mitotic cell cycle;mitochondrial transport;neutrophil degranulation;positive regulation of nitric oxide biosynthetic process;positive regulation of telomerase activity;protein import into mitochondrial outer membrane;protein refolding;protein stabilization;protein unfolding;receptor-mediated endocytosis;regulation of cellular response to heat;regulation of G2/M transition of mitotic cell cycle;regulation of nitric-oxide synthase activity;regulation of protein complex assembly;regulation of protein ubiquitination;response to antibiotic;response to cold;response to heat;response to unfolded protein;signal transduction;telomerase holoenzyme complex assembly;telomere maintenance via telomerase;vascular endothelial growth factor receptor signaling pathway","ATP binding;ATPase activity;disordered domain specific binding;DNA polymerase binding;GTPase binding;histone deacetylase binding;identical protein binding;MHC class II protein complex binding;nitric-oxide synthase regulator activity;nucleotide binding;protein homodimerization activity;protein tyrosine kinase activity;protein tyrosine kinase binding;RNA binding;TPR domain binding;unfolded protein binding","cytoplasm;cytosol;endocytic vesicle lumen;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;lysosomal lumen;melanosome;membrane;myelin sheath;nucleoplasm;nucleus;plasma membrane;protein complex;ruffle membrane;secretory granule lumen","Antigen processing and presentation;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;IL-17 signaling pathway;Necroptosis;NOD-like receptor signaling pathway;Pathways in cancer;PI3K-Akt signaling pathway;Progesterone-mediated oocyte maturation;Prostate cancer;Protein processing in endoplasmic reticulum;Th17 cell differentiation",null,null,42,30,30,"59.8","44.3","44.3","84.659",0,"323.31",36910000000,863,"0.103736",1,"0.0868731","0.307506","sp|P07900|HS90A_HUMAN;tr|G3V2J8|G3V2J8_HUMAN;sp|Q14568|HS902_HUMAN;sp|Q58FG0|HS905_HUMAN","sp|P07900|HS90A_HUMAN",906,"P07900","HS90A_HUMAN","Heat shock protein HSP 90-alpha",null,"HSP90AA1"]
["24.1104","24.574","24.117","24.3938",{"$nulls":3},"ATP biosynthetic process;cristae formation;mitochondrial ATP synthesis coupled proton transport;oxidative phosphorylation","proton-transporting ATP synthase activity, rotational mechanism;RNA binding;transmembrane transporter activity","extracellular exosome;membrane;mitochondrial inner membrane;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);mitochondrion;myelin sheath","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,10,10,10,"41.9","41.9","41.9","32.996",0,"87.383",7095300000,302,"0.108912",1,"0.086853","0.321693","sp|P36542|ATPG_HUMAN","sp|P36542|ATPG_HUMAN",1406,"P36542","ATPG_HUMAN","ATP synthase subunit gamma, mitochondrial",null,"ATP5C1"]
["21.0568","20.9409","21.1868","20.6378",{"$nulls":3},"ER to Golgi vesicle-mediated transport;intracellular protein transport","zinc ion binding","COPII vesicle coat",{"$nulls":3},12,12,12,17,17,17,"111.98",0,"63.296",668320000,60,"0.104075",1,"0.0865393","0.308438","tr|G5EA31|G5EA31_HUMAN;sp|P53992|SC24C_HUMAN","tr|G5EA31|G5EA31_HUMAN;sp|P53992|SC24C_HUMAN",1728,"G5EA31","G5EA31_HUMAN"]
["24.9194","24.8857","24.7739","24.8594",{"$nulls":3},"translation","structural constituent of ribosome","cytosol;endoplasmic reticulum;nucleolus;ribosome",{"$nulls":3},8,8,8,"43.9","43.9","43.9","18.756",0,"62.41",2438500000,122,"0.693342",1,"0.0858498","1.86869","tr|G3V203|G3V203_HUMAN;sp|Q07020|RL18_HUMAN;tr|J3QQ67|J3QQ67_HUMAN;tr|H0YHA7|H0YHA7_HUMAN;tr|F8VYV2|F8VYV2_HUMAN;tr|A0A075B7A0|A0A075B7A0_HUMAN;tr|F8VUA6|F8VUA6_HUMAN;tr|F8VXR6|F8VXR6_HUMAN","tr|G3V203|G3V203_HUMAN;sp|Q07020|RL18_HUMAN;tr|J3QQ67|J3QQ67_HUMAN;tr|H0YHA7|H0YHA7_HUMAN;tr|F8VYV2|F8VYV2_HUMAN;tr|A0A075B7A0|A0A075B7A0_HUMAN;tr|F8VUA6|F8VUA6_HUMAN",2116,"G3V203","G3V203_HUMAN"]
["18.2146","17.9286","17.1481","18.824",{"$nulls":4},"ATP binding","cytoplasm",{"$nulls":3},9,9,9,"17.8","17.8","17.8","80.709",0,"24.892",144230000,16,"0.0319793",1,"0.0855579","0.100648","sp|Q9BVQ7|SPA5L_HUMAN;tr|H0YCA5|H0YCA5_HUMAN","sp|Q9BVQ7|SPA5L_HUMAN",4015,"Q9BVQ7","SPA5L_HUMAN","Spermatogenesis-associated protein 5-like protein 1",null,"SPATA5L1"]
["22.4739","23.1818","22.8253","22.6611",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;osteoblast differentiation;positive regulation of DNA-templated transcription, elongation;regulation of DNA recombination;replication fork processing;RNA export from nucleus;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus;viral process","RNA binding","catalytic step 2 spliceosome;cytosol;extracellular exosome;membrane;nuclear speck;nucleoplasm;transcription export complex","Herpes simplex virus 1 infection;mRNA surveillance pathway;RNA transport;Spliceosome",null,null,6,6,6,"43.2","43.2","43.2","26.888",0,"105.95",1025700000,63,"0.0770375",1,"0.0846519","0.232969","sp|Q86V81|THOC4_HUMAN;tr|E9PB61|E9PB61_HUMAN","sp|Q86V81|THOC4_HUMAN;tr|E9PB61|E9PB61_HUMAN",3058,"Q86V81","THOC4_HUMAN","THO complex subunit 4","ho4","ALYREF"]
["22.4986","21.356","22.4753","21.2134",{"$nulls":3},"RNA splicing","RNA binding","nuclear speck",{"$nulls":3},7,7,7,"24.4","24.4","24.4","42.316",0,"20.812",510810000,48,"0.0309351",1,"0.0829573","0.097462","tr|Q5T760|Q5T760_HUMAN;sp|Q05519|SRS11_HUMAN;tr|B4DWT1|B4DWT1_HUMAN;tr|Q5T757|Q5T757_HUMAN;tr|S4R3C4|S4R3C4_HUMAN","tr|Q5T760|Q5T760_HUMAN;sp|Q05519|SRS11_HUMAN",2103,"Q5T760","Q5T760_HUMAN",null,null,"SRSF11"]
["19.1561","18.308","19.3994","17.9008",{"$nulls":3},"maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);negative regulation of cell migration;negative regulation of cell proliferation;negative regulation of cell-cell adhesion;negative regulation of collagen binding;negative regulation of DNA replication;negative regulation of protein ubiquitination;osteoblast differentiation;protein stabilization;regulation of cyclin-dependent protein serine/threonine kinase activity","GTP binding;GTPase activity;RNA binding","cytoplasm;cytosol;Golgi apparatus;membrane;nuclear membrane;nucleolus;nucleus;perinuclear region of cytoplasm","Ribosome biogenesis in eukaryotes",null,null,27,27,27,"47.3","47.3","47.3","73.964",0,"175.36",2429400000,209,"0.0301891",1,"0.0819445","0.0951821","sp|Q9BZE4|NOG1_HUMAN;tr|Q5T3R7|Q5T3R7_HUMAN","sp|Q9BZE4|NOG1_HUMAN",4074,"Q9BZE4","NOG1_HUMAN","Nucleolar GTP-binding protein 1",null,"GTPBP4"]
["18.3314","17.8635","17.7085","18.3239",{"$nulls":3},"adult locomotory behavior;developmental growth;microtubule cytoskeleton organization;mitotic spindle organization;muscle atrophy;peripheral nervous system neuron axonogenesis;post-chaperonin tubulin folding pathway;post-embryonic development;protein folding","chaperone binding","cytoplasm;microtubule",{"$nulls":3},7,7,7,"20.3","20.3","20.3","59.345",0,"16.132",97750000,8,"0.0690569",1,"0.0812378","0.21019","sp|Q15813|TBCE_HUMAN","sp|Q15813|TBCE_HUMAN",2525,"Q15813","TBCE_HUMAN","Tubulin-specific chaperone E",null,"TBCE"]
["13.9599","15.308","14.4055","14.7001",{"$nulls":3},"microtubule-based movement;spindle assembly","ATP binding;cholesterol binding;microtubule binding;microtubule motor activity","centriole;cytoplasm;nucleus",{"$nulls":3},2,2,2,"0.3","0.3","0.3","516.34","0.008694","2.2819",67022000,7,"0.0375839",1,"0.081171","0.117645","sp|Q9P2P6|STAR9_HUMAN;tr|H3BMX7|H3BMX7_HUMAN","sp|Q9P2P6|STAR9_HUMAN;tr|H3BMX7|H3BMX7_HUMAN",4647,"Q9P2P6","STAR9_HUMAN","StAR-related lipid transfer protein 9",null,"STARD9"]
["24.0112","23.8832","24.2869","23.447",{"$nulls":3},"regulation of apoptotic process;regulation of mRNA stability","cadherin binding;mRNA 3'-UTR binding;RNA binding","cytoplasm;cytosol;extracellular exosome;membrane;nucleus;perinuclear region of cytoplasm;plasma membrane",{"$nulls":3},20,20,20,"56.4","56.4","56.4","44.965",0,"178.29",2531300000,152,"0.0616629",1,"0.0802336","0.188854","sp|Q8NC51|PAIRB_HUMAN","sp|Q8NC51|PAIRB_HUMAN",3298,"Q8NC51","PAIRB_HUMAN","Plasminogen activator inhibitor 1 RNA-binding protein",null,"SERBP1"]
["18.669",1,"18.5099",1,{"$nulls":3},"sphingomyelin catabolic process","sphingomyelin phosphodiesterase activity","extracellular space",{"$nulls":3},2,2,2,"9.6","9.6","9.6","45.314","0.0015041","3.5774",14413000,2,"0.0019676",1,"0.0795116","0.00639277","tr|F8VWW8|F8VWW8_HUMAN;sp|Q92485|ASM3B_HUMAN;tr|Q5T0Y8|Q5T0Y8_HUMAN","tr|F8VWW8|F8VWW8_HUMAN;sp|Q92485|ASM3B_HUMAN;tr|Q5T0Y8|Q5T0Y8_HUMAN",3479,"F8VWW8","F8VWW8_HUMAN",null,null,"SMPDL3B"]
["18.7614","19.6282","19.233","18.9993",{"$nulls":3},"DNA replication;DNA synthesis involved in DNA repair;innate immune response;regulation of DNA-dependent DNA replication initiation","ATP binding;ATPase activity;DNA binding;identical protein binding;metal ion binding","membrane;nucleus;perinuclear region of cytoplasm",{"$nulls":3},7,7,7,"13.2","13.2","13.2","72.132",0,"13.589",138770000,8,"0.0569525",1,"0.0786161","0.175139","sp|Q96S55|WRIP1_HUMAN","sp|Q96S55|WRIP1_HUMAN",3813,"Q96S55","WRIP1_HUMAN","ATPase WRNIP1",null,"WRNIP1"]
["26.7806","26.5381","26.9622","26.1997",{"$nulls":4},"electron transfer activity;heme binding;metal ion binding","mitochondrion;respiratory chain",{"$nulls":3},8,8,8,"58.4","58.4","58.4","11.333",0,"92.771",5096500000,119,"0.0641055",1,"0.0783892","0.195928","tr|C9JFR7|C9JFR7_HUMAN;sp|P99999|CYC_HUMAN;CON__P62894","tr|C9JFR7|C9JFR7_HUMAN;sp|P99999|CYC_HUMAN",2025,"C9JFR7","C9JFR7_HUMAN",null,null,"CYCS"]
["23.5088","23.268","23.5939","23.0271",{"$nulls":3},"cristae formation;mitochondrial calcium ion homeostasis","RNA binding","membrane;MICOS complex;mitochondrial inner membrane;mitochondrion;myelin sheath",{"$nulls":3},31,31,3,"51.7","51.7","8.3","83.677",0,"257.36",4266900000,278,"0.0841499",1,"0.0779257","0.253066","sp|Q16891|MIC60_HUMAN;tr|B9A067|B9A067_HUMAN;tr|D6RAW4|D6RAW4_HUMAN","sp|Q16891|MIC60_HUMAN;tr|B9A067|B9A067_HUMAN",2582,"Q16891","MIC60_HUMAN","MICOS complex subunit MIC60",null,"IMMT"]
["24.8159","24.2107","24.9644","23.9091",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of endopeptidase activity;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of G1/S transition of mitotic cell cycle;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of proteasomal protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activator activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm;proteasome activator complex;proteasome complex","Antigen processing and presentation;Proteasome",null,null,17,17,17,"70.3","70.3","70.3","28.723",0,"165.98",3289500000,146,"0.0403046",1,"0.0765381","0.125835","sp|Q06323|PSME1_HUMAN;tr|H0YLU2|H0YLU2_HUMAN;tr|H0YKK6|H0YKK6_HUMAN","sp|Q06323|PSME1_HUMAN",2111,"Q06323","PSME1_HUMAN","Proteasome activator complex subunit 1",null,"PSME1"]
["16.8467","17.5474","17.2453","16.9981",{"$nulls":4},"microtubule motor activity","cytoplasm;kinesin complex;microtubule","Salmonella infection",null,null,7,5,5,"14.4","11.3","11.3","68.639",0,"16.8",54386000,10,"0.0665348",1,"0.0753946","0.202938","sp|Q9NSK0|KLC4_HUMAN;tr|C9J8T5|C9J8T5_HUMAN;tr|H7C4M1|H7C4M1_HUMAN;tr|C9JZE5|C9JZE5_HUMAN","sp|Q9NSK0|KLC4_HUMAN",4445,"Q9NSK0","KLC4_HUMAN","Kinesin light chain 4","LC 4","KLC4"]
["24.3982","24.6598","24.5125","24.3971",{"$nulls":3},"chaperone-mediated protein folding;negative regulation of cellular respiration;negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;negative regulation of reactive oxygen species biosynthetic process;response to stress;translational attenuation","ATP binding;protein kinase binding;RNA binding;tumor necrosis factor receptor binding;unfolded protein binding","extracellular exosome;lipid droplet;membrane;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;nucleoplasm",{"$nulls":3},32,32,32,"54.5","54.5","54.5","80.109",0,"323.31",8111200000,278,"0.183468",1,"0.074213","0.51907","sp|Q12931|TRAP1_HUMAN;tr|I3L0K7|I3L0K7_HUMAN;tr|I3L239|I3L239_HUMAN;tr|I3L253|I3L253_HUMAN;tr|I3L2D5|I3L2D5_HUMAN","sp|Q12931|TRAP1_HUMAN;tr|I3L0K7|I3L0K7_HUMAN",2181,"Q12931","TRAP1_HUMAN","Heat shock protein 75 kDa, mitochondrial","SP 75","TRAP1"]
["22.8296","23.4903","23.0647","23.1075",{"$nulls":3},"isoleucyl-tRNA aminoacylation;osteoblast differentiation;tRNA aminoacylation for protein translation","aminoacyl-tRNA editing activity;ATP binding;GTPase binding;isoleucine-tRNA ligase activity;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;extracellular exosome;membrane","Aminoacyl-tRNA biosynthesis",null,null,54,54,54,"52.5","52.5","52.5","144.5",0,"323.31",15278000000,882,"0.0735781",1,"0.0738659","0.223125","sp|P41252|SYIC_HUMAN;tr|A0A0A0MSX9|A0A0A0MSX9_HUMAN;tr|J3KR24|J3KR24_HUMAN;tr|Q5TCD1|Q5TCD1_HUMAN;tr|Q5TCC6|Q5TCC6_HUMAN;tr|Q5TCC9|Q5TCC9_HUMAN","sp|P41252|SYIC_HUMAN;tr|A0A0A0MSX9|A0A0A0MSX9_HUMAN;tr|J3KR24|J3KR24_HUMAN",1458,"P41252","SYIC_HUMAN","Isoleucine--tRNA ligase, cytoplasmic",null,"IARS"]
["22.1526","21.9209","22.3998","21.5271",{"$nulls":3},"'de novo' IMP biosynthetic process;glutamine metabolic process;purine ribonucleoside monophosphate biosynthetic process;response to drug","ATP binding;metal ion binding;phosphoribosylformylglycinamidine synthase activity","cytoplasm;cytosol;extracellular exosome","Metabolic pathways;Purine metabolism",null,null,26,26,26,"32.1","32.1","32.1","144.73",0,"295.71",1953200000,108,"0.0525898",1,"0.0732937","0.162347","sp|O15067|PUR4_HUMAN;tr|H0YGH1|H0YGH1_HUMAN;tr|J3QSG0|J3QSG0_HUMAN;tr|J3QSH6|J3QSH6_HUMAN;tr|J3KT98|J3KT98_HUMAN;tr|J3KTQ5|J3KTQ5_HUMAN;tr|J3KTL4|J3KTL4_HUMAN","sp|O15067|PUR4_HUMAN",320,"O15067","PUR4_HUMAN","Phosphoribosylformylglycinamidine synthase","GAM synthase;GAMS","PFAS"]
["20.1926","19.7605","20.7973","19.0122",{"$nulls":3},"DNA damage response, detection of DNA damage;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleolus","Ribosome",null,null,12,12,12,"29.3","29.3","29.3","45.834",0,"32.863",299430000,29,"0.0246366",1,"0.0717316","0.0781111","sp|P82933|RT09_HUMAN;tr|H7BZC4|H7BZC4_HUMAN","sp|P82933|RT09_HUMAN",1999,"P82933","RT09_HUMAN","28S ribosomal protein S9, mitochondrial","9mt;RP-S9","MRPS9"]
["20.444","21.1925","20.5756","20.9179",{"$nulls":3},"cell cycle;intracellular signal transduction;peptidyl-serine phosphorylation;positive regulation of inflammatory response;positive regulation of interleukin-6 production;regulation of gene expression;regulation of transcription, DNA-templated;response to osmotic stress;response to stress;transcription, DNA-templated;vascular endothelial growth factor receptor signaling pathway","ATP binding;MAP kinase activity;protein serine/threonine kinase activity","cytoplasm;cytosol;nucleus","Adrenergic signaling in cardiomyocytes;AGE-RAGE signaling pathway in diabetic complications;Amyotrophic lateral sclerosis (ALS);Cellular senescence;Chagas disease (American trypanosomiasis);C-type lectin receptor signaling pathway;Dopaminergic synapse;Endocrine resistance;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;FoxO signaling pathway;GnRH signaling pathway;Hepatitis B;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;IL-17 signaling pathway;Inflammatory mediator regulation of TRP channels;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Leukocyte transendothelial migration;MAPK signaling pathway;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Oocyte meiosis;Osteoclast differentiation;PD-L1 expression and PD-1 checkpoint pathway in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Relaxin signaling pathway;Retrograde endocannabinoid signaling;RIG-I-like receptor signaling pathway;Salmonella infection;Shigellosis;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thermogenesis;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;VEGF signaling pathway;Yersinia infection",null,null,6,6,6,"17.8","17.8","17.8","42.089",0,"18.205",328220000,19,"0.0564737",1,"0.071496","0.17374","sp|O15264|MK13_HUMAN;tr|Q5R3E6|Q5R3E6_HUMAN","sp|O15264|MK13_HUMAN",345,"O15264","MK13_HUMAN","Mitogen-activated protein kinase 13","AP kinase 13;APK 13","MAPK13"]
["21.3801","20.9919","21.5451","20.6854",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;translation","structural constituent of ribosome","cytosol;mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion","Ribosome",null,null,5,5,5,"52.6","52.6","52.6","15.345",0,"23.27",246840000,35,"0.0483784",1,"0.0707073","0.149915","sp|Q9Y3D3|RT16_HUMAN;tr|A6ND22|A6ND22_HUMAN","sp|Q9Y3D3|RT16_HUMAN;tr|A6ND22|A6ND22_HUMAN",4983,"Q9Y3D3","RT16_HUMAN","28S ribosomal protein S16, mitochondrial","16mt;RP-S16","MRPS16"]
["20.5503","19.8173","20.9173","19.3099",{"$nulls":3},"autophagy;cellular response to DNA damage stimulus;cellular response to interleukin-1;DNA damage response, signal transduction by p53 class mediator;negative regulation of I-kappaB kinase/NF-kappaB signaling;protein deubiquitination;regulation of autophagy;translesion synthesis;ubiquitin-dependent protein catabolic process","cysteine-type endopeptidase activity;ion channel binding;p53 binding;RNA binding;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity","cytoplasm;cytosol;early endosome;nucleoplasm;nucleus;protein complex",{"$nulls":3},16,16,16,"28.3","28.3","28.3","87.133",0,"77.163",499730000,37,"0.0250723",1,"0.0701857","0.0794573","sp|Q14694|UBP10_HUMAN;tr|H3BQP1|H3BQP1_HUMAN;tr|J3KT19|J3KT19_HUMAN;tr|H3BNS8|H3BNS8_HUMAN;tr|H3BNA1|H3BNA1_HUMAN;tr|H3BVF1|H3BVF1_HUMAN;tr|H3BNL0|H3BNL0_HUMAN;tr|Q68D90|Q68D90_HUMAN;tr|H3BQC6|H3BQC6_HUMAN","sp|Q14694|UBP10_HUMAN",2387,"Q14694","UBP10_HUMAN","Ubiquitin carboxyl-terminal hydrolase 10",null,"USP10"]
["23.9169","24.3024","24.0672","24.0127",{"$nulls":3},"actin cytoskeleton organization;cellular response to interferon-gamma;cytoskeletal anchoring at plasma membrane;epithelial cell morphogenesis;keratinocyte development;signal transduction;skeletal muscle tissue development","actin binding;cadherin binding;identical protein binding;RNA binding","actin cytoskeleton;brush border;cell cortex;cytoplasm;cytosol;extracellular exosome;extracellular matrix;focal adhesion;integral component of membrane;phagocytic vesicle;plasma membrane;stress fiber;Z disc","Focal adhesion;MAPK signaling pathway;Proteoglycans in cancer;Salmonella infection",null,null,128,128,116,"68.7","68.7","64.2","278.16",0,"323.31",22325000000,938,"0.122286",1,"0.0696974","0.358001","sp|O75369|FLNB_HUMAN;tr|E7EN95|E7EN95_HUMAN;tr|A0A0A0MT44|A0A0A0MT44_HUMAN;tr|H7C5L4|H7C5L4_HUMAN;tr|A0A0C4DGA1|A0A0C4DGA1_HUMAN","sp|O75369|FLNB_HUMAN;tr|E7EN95|E7EN95_HUMAN",554,"O75369","FLNB_HUMAN","Filamin-B","LN-B","FLNB"]
["22.0961","22.5893","22.3542","22.1945",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;ribosomal large subunit assembly;translation","RNA binding;rRNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome;mitochondrion","Ribosome",null,null,8,8,8,"45.8","45.8","45.8","20.683",0,"49.322",746760000,57,"0.0879448",1,"0.0683498","0.263714","sp|Q9Y3B7|RM11_HUMAN;tr|H0YCD5|H0YCD5_HUMAN;tr|E9PQB6|E9PQB6_HUMAN","sp|Q9Y3B7|RM11_HUMAN",4975,"Q9Y3B7","RM11_HUMAN","39S ribosomal protein L11, mitochondrial","11mt;RP-L11","MRPL11"]
[1,"18.051",1,"17.9146",{"$nulls":3},"bicarbonate transport;one-carbon metabolic process","carbonate dehydratase activity;zinc ion binding","cytosol;intracellular membrane-bounded organelle;myelin sheath","Metabolic pathways;Nitrogen metabolism",null,null,2,2,2,"13.7","13.7","13.7","29.443","0.0081712","2.3622",25005000,3,"0.00174827",1,"0.0682287","0.00568159","sp|Q8N1Q1|CAH13_HUMAN","sp|Q8N1Q1|CAH13_HUMAN",3202,"Q8N1Q1","CAH13_HUMAN","Carbonic anhydrase 13",null,"CA13"]
["16.6032","17.7155","16.5149","17.6687",{"$nulls":3},"apoptotic process;central nervous system development;mRNA 3'-end processing;mRNA export from nucleus;negative regulation of apoptotic process;RNA export from nucleus;RNA splicing;termination of RNA polymerase II transcription;viral mRNA export from host cell nucleus","RNA binding","nuclear body;nuclear speck;nucleoplasm;nucleus;THO complex;THO complex part of transcription export complex;transcription export complex","RNA transport",null,null,3,3,3,"14.4","14.4","14.4","37.535",0,"11.183",99053000,8,"0.0266284",1,"0.0675173","0.0842557","sp|Q86W42|THOC6_HUMAN","sp|Q86W42|THOC6_HUMAN",3065,"Q86W42","THOC6_HUMAN","THO complex subunit 6 homolog",null,"THOC6"]
["19.4006","19.6597","19.0832","19.8428",{"$nulls":3},"UDP-N-acetylglucosamine biosynthetic process","UDP-N-acetylglucosamine diphosphorylase activity","cytosol","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,8,8,7,"21.3","21.3","18.7","57.03",0,"17.642",190840000,12,"0.0542998",1,"0.0671616","0.167372","sp|Q3KQV9|UAP1L_HUMAN;tr|A0A087X226|A0A087X226_HUMAN","sp|Q3KQV9|UAP1L_HUMAN",2615,"Q3KQV9","UAP1L_HUMAN","UDP-N-acetylhexosamine pyrophosphorylase-like protein 1",null,"UAP1L1"]
["23.3688","23.7376","23.6938","23.2787",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;cellular hyperosmotic response;cellular response to tumor necrosis factor;fertilization;in utero embryonic development;male gonad development;negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;negative regulation of necroptotic process;negative regulation of skeletal muscle tissue development;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cytoplasmic translation;positive regulation of organ growth;response to cold;spermatogenesis;transcription, DNA-templated","DNA binding transcription factor activity;double-stranded DNA binding;mRNA 3'-UTR binding;Rho GTPase binding;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;single-stranded DNA binding;transcription corepressor activity;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","bicellular tight junction;cytoplasm;cytosol;nucleus;perinuclear region of cytoplasm;polysome","Tight junction",null,null,12,8,8,"53.8","43.8","43.8","40.089",0,"99.291",1308500000,82,"0.0799193",1,"0.0669498","0.241134","sp|P16989|YBOX3_HUMAN;tr|A0A0D9SEI8|A0A0D9SEI8_HUMAN","sp|P16989|YBOX3_HUMAN",1089,"P16989","YBOX3_HUMAN","Y-box-binding protein 3",null,"YBX3"]
["21.5966","22.211","21.898","21.7769",{"$nulls":3},"cellular detoxification of nitrogen compound;establishment of blood-nerve barrier;glutathione derivative biosynthetic process;glutathione metabolic process;nitrobenzene metabolic process;response to estrogen;xenobiotic catabolic process","enzyme binding;glutathione binding;glutathione transferase activity;identical protein binding;protein homodimerization activity","cytoplasm;cytosol;extracellular exosome;nucleus;sperm fibrous sheath","Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Fluid shear stress and atherosclerosis;Glutathione metabolism;Hepatocellular carcinoma;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pathways in cancer;Platinum drug resistance",null,null,10,10,10,"50.7","50.7","50.7","26.559",0,"50.763",582670000,36,"0.0696366",1,"0.0663328","0.211853","sp|P21266|GSTM3_HUMAN;tr|A0A0A0MTN3|A0A0A0MTN3_HUMAN;tr|E9PLF1|E9PLF1_HUMAN;tr|E9PHN7|E9PHN7_HUMAN;tr|E9PHN6|E9PHN6_HUMAN;tr|Q5T8Q9|Q5T8Q9_HUMAN;tr|Q5T8R1|Q5T8R1_HUMAN;sp|P46439|GSTM5_HUMAN;sp|P28161|GSTM2_HUMAN;tr|F6XZQ7|F6XZQ7_HUMAN","sp|P21266|GSTM3_HUMAN;tr|A0A0A0MTN3|A0A0A0MTN3_HUMAN",1159,"P21266","GSTM3_HUMAN","Glutathione S-transferase Mu 3",null,"GSTM3"]
["19.5149","21.1292","19.9202","20.5929",{"$nulls":3},"negative regulation of protein kinase activity;positive regulation of transcription from RNA polymerase II promoter;RNA transport;transcription, DNA-templated;tRNA splicing, via endonucleolytic cleavage and ligation;viral process","identical protein binding;RNA binding;RNA polymerase II core binding","centrosome;cytoplasm;cytosol;mitotic spindle;nucleoplasm;nucleus;perinuclear region of cytoplasm;tRNA-splicing ligase complex",{"$nulls":3},7,7,7,"38.5","38.5","38.5","28.068",0,"42.646",215320000,19,"0.0235955",1,"0.065485","0.0748898","sp|Q9Y224|CN166_HUMAN;tr|H0YJB9|H0YJB9_HUMAN;tr|G3V4C6|G3V4C6_HUMAN","sp|Q9Y224|CN166_HUMAN;tr|H0YJB9|H0YJB9_HUMAN;tr|G3V4C6|G3V4C6_HUMAN",4889,"Q9Y224","RTRAF_HUMAN","RNA transcription, translation and transport factor protein {ECO:0000312|HGNC:HGNC:23169}",null,"RTRAF"]
["21.231","21.1941","21.6214","20.6756",{"$nulls":3},"angiogenesis;apoptotic process;cell differentiation;negative regulation of apoptotic process;nuclear import;regulation of angiogenesis;regulation of transcription from RNA polymerase II promoter;viral process","oxidoreductase activity;transcription coactivator activity","cytoplasm;cytosol;membrane;nuclear envelope;nucleus",{"$nulls":3},9,9,9,"37.2","37.2","37.2","27.049",0,"16.184",268390000,22,"0.0434744",1,"0.0640516","0.135328","sp|Q9BUP3|HTAI2_HUMAN;tr|E9PI87|E9PI87_HUMAN","sp|Q9BUP3|HTAI2_HUMAN;tr|E9PI87|E9PI87_HUMAN",3992,"Q9BUP3","HTAI2_HUMAN","Oxidoreductase HTATIP2",null,"HTATIP2"]
["22.3365","21.3372","22.4748","21.0712",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","hydrolase activity;structural constituent of ribosome","cell junction;mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion;nucleoplasm",{"$nulls":3},8,8,8,"36.9","36.9","36.9","31.705",0,"67.614",955440000,60,"0.0233427",1,"0.0638428","0.0741069","sp|Q9H2W6|RM46_HUMAN;tr|A0A087WT90|A0A087WT90_HUMAN;tr|A0A087WT51|A0A087WT51_HUMAN","sp|Q9H2W6|RM46_HUMAN",4179,"Q9H2W6","RM46_HUMAN","39S ribosomal protein L46, mitochondrial","46mt;RP-L46","MRPL46"]
["24.8016","24.8038","25.0344","24.444",{"$nulls":3},"cell proliferation;neutrophil degranulation;signal transduction","RNA binding","extracellular region;ficolin-1-rich granule lumen",{"$nulls":3},6,6,6,"35.9","35.9","35.9","20.63",0,"137.8",1856400000,73,"0.0707207",1,"0.0634508","0.21496","sp|Q13442|HAP28_HUMAN;tr|F8WBW6|F8WBW6_HUMAN","sp|Q13442|HAP28_HUMAN",2256,"Q13442","HAP28_HUMAN","28 kDa heat- and acid-stable phosphoprotein",null,"PDAP1"]
["23.1351","23.5845","23.5054","23.0909",{"$nulls":3},"positive regulation of cell proliferation;protein refolding;response to heat","ATP binding;ATPase activator activity;chaperone binding;heat shock protein binding;metal ion binding;unfolded protein binding","cytosol;extracellular exosome;membrane","Protein processing in endoplasmic reticulum",null,null,15,15,15,"50.5","50.5","50.5","45.745",0,"263.82",4026100000,289,"0.0660923",1,"0.0616465","0.201663","sp|O60884|DNJA2_HUMAN;tr|A0A087WT48|A0A087WT48_HUMAN;tr|I3L320|I3L320_HUMAN","sp|O60884|DNJA2_HUMAN",512,"O60884","DNJA2_HUMAN","DnaJ homolog subfamily A member 2",null,"DNAJA2"]
["25.5781","25.3215","25.9229","24.8541",{"$nulls":3},"translational elongation","translation elongation factor activity","cytoplasm;cytosol;eukaryotic translation elongation factor 1 complex",{"$nulls":3},9,8,8,64,"59.1","59.1","24.763",0,"323.31",5130400000,151,"0.0355854",1,"0.0613384","0.111604","sp|P24534|EF1B_HUMAN;tr|C9JZW3|C9JZW3_HUMAN;tr|F2Z2G2|F2Z2G2_HUMAN;tr|F8WF65|F8WF65_HUMAN","sp|P24534|EF1B_HUMAN",1211,"P24534","EF1B_HUMAN","Elongation factor 1-beta","F-1-beta","EEF1B2"]
["21.0441","21.4133","21.1171","21.2214",{"$nulls":5},"nucleus",{"$nulls":3},1,1,1,"22.4","22.4","22.4","8.2526","0.008699","2.2916",60071000,1,"0.104682",1,"0.0594797","0.310105","tr|E9PR95|E9PR95_HUMAN;tr|E9PSC3|E9PSC3_HUMAN;tr|E9PLC5|E9PLC5_HUMAN;tr|E9PLB3|E9PLB3_HUMAN;tr|E9PIP1|E9PIP1_HUMAN;tr|E9PPB5|E9PPB5_HUMAN;tr|E9PQS1|E9PQS1_HUMAN;tr|A0A087WT99|A0A087WT99_HUMAN;sp|Q9H0W9|CK054_HUMAN","tr|E9PR95|E9PR95_HUMAN;tr|E9PSC3|E9PSC3_HUMAN;tr|E9PLC5|E9PLC5_HUMAN;tr|E9PLB3|E9PLB3_HUMAN;tr|E9PIP1|E9PIP1_HUMAN;tr|E9PPB5|E9PPB5_HUMAN;tr|E9PQS1|E9PQS1_HUMAN;tr|A0A087WT99|A0A087WT99_HUMAN;sp|Q9H0W9|CK054_HUMAN",4150,"E9PR95","E9PR95_HUMAN",null,null,"C11orf54"]
["23.8026","24.023","23.9946","23.7126",{"$nulls":3},"aging;cellular response to amino acid starvation;cellular response to heat;cellular response to UV;negative regulation of guanyl-nucleotide exchange factor activity;negative regulation of translational initiation in response to stress;PERK-mediated unfolded protein response;positive regulation of neuron death;positive regulation of type B pancreatic cell apoptotic process;protein autophosphorylation;response to endoplasmic reticulum stress;response to manganese-induced endoplasmic reticulum stress;translational initiation;transmembrane transport","ribosome binding;RNA binding;translation initiation factor activity","cytoplasmic stress granule;cytosol;eukaryotic 48S preinitiation complex;eukaryotic translation initiation factor 2 complex;extracellular exosome;glial limiting end-foot;membrane;multi-eIF complex;nucleus;polysome;ribosome;translation initiation ternary complex","Apoptosis;Autophagy - animal;Hepatitis C;Herpes simplex virus 1 infection;Influenza A;Measles;Non-alcoholic fatty liver disease (NAFLD);Protein processing in endoplasmic reticulum;RNA transport",null,null,28,28,28,"82.9","82.9","82.9","36.112",0,"323.31",21819000000,831,"0.112231",1,"0.0591917","0.330749","sp|P05198|IF2A_HUMAN;tr|G3V4T5|G3V4T5_HUMAN;tr|H0YJS4|H0YJS4_HUMAN","sp|P05198|IF2A_HUMAN;tr|G3V4T5|G3V4T5_HUMAN;tr|H0YJS4|H0YJS4_HUMAN",861,"P05198","IF2A_HUMAN","Eukaryotic translation initiation factor 2 subunit 1",null,"EIF2S1"]
["18.1887",1,"18.0731",1,{"$nulls":3},"metabolic process","catalytic activity",{"$nulls":4},1,1,1,"8.2","8.2","8.2","20.3","0.0037275","3.1076",17404000,0,"0.00146869",1,"0.0578356","0.0047745","tr|H0YGC7|H0YGC7_HUMAN;tr|F5H362|F5H362_HUMAN;tr|F5H755|F5H755_HUMAN;tr|F5H5A1|F5H5A1_HUMAN;sp|Q4G176|ACSF3_HUMAN","tr|H0YGC7|H0YGC7_HUMAN;tr|F5H362|F5H362_HUMAN;tr|F5H755|F5H755_HUMAN;tr|F5H5A1|F5H5A1_HUMAN;sp|Q4G176|ACSF3_HUMAN",2631,"H0YGC7","H0YGC7_HUMAN",null,null,"ACSF3"]
["16.9263","17.1911","16.0435","17.9595",{"$nulls":3},"androgen receptor signaling pathway;intracellular steroid hormone receptor signaling pathway;positive regulation of transcription, DNA-templated;transcription initiation from RNA polymerase II promoter","ligand-dependent nuclear receptor transcription coactivator activity;receptor activity;RNA polymerase II transcription cofactor activity;thyroid hormone receptor binding;transcription cofactor activity;vitamin D receptor binding","mediator complex;nucleoplasm;nucleus","Thyroid hormone signaling pathway",null,null,16,16,16,"22.6","22.6","22.6","110.3",0,"75.141",613120000,95,"0.0185263",1,"0.0571661","0.0591109","sp|O75448|MED24_HUMAN;tr|A0A0B4J1W0|A0A0B4J1W0_HUMAN;tr|F5GY88|F5GY88_HUMAN;tr|B4DDR8|B4DDR8_HUMAN;tr|F5H5K2|F5H5K2_HUMAN;tr|E9PFL1|E9PFL1_HUMAN;tr|J3KSU0|J3KSU0_HUMAN;tr|F5H2D6|F5H2D6_HUMAN;tr|B9TX62|B9TX62_HUMAN;tr|J3QRH9|J3QRH9_HUMAN;tr|H0YEG1|H0YEG1_HUMAN;tr|F5H3E6|F5H3E6_HUMAN;tr|B9TX75|B9TX75_HUMAN;tr|J3QLF8|J3QLF8_HUMAN;tr|J3KTL3|J3KTL3_HUMAN;tr|J3QLC0|J3QLC0_HUMAN;tr|F5H0M2|F5H0M2_HUMAN;tr|J3KSL1|J3KSL1_HUMAN","sp|O75448|MED24_HUMAN;tr|A0A0B4J1W0|A0A0B4J1W0_HUMAN;tr|F5GY88|F5GY88_HUMAN;tr|B4DDR8|B4DDR8_HUMAN;tr|F5H5K2|F5H5K2_HUMAN",572,"O75448","MED24_HUMAN","Mediator of RNA polymerase II transcription subunit 24",null,"MED24"]
["21.8433","21.8085","22.0646","21.4748",{"$nulls":3},"cellular response to leukemia inhibitory factor;defense response to virus;ERAD pathway;innate immune response;interferon-gamma-mediated signaling pathway;negative regulation of type I interferon production;negative regulation of viral entry into host cell;negative regulation of viral release from host cell;positive regulation of DNA binding transcription factor activity;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;protein deubiquitination;protein monoubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of viral entry into host cell;regulation of viral release from host cell;response to estrogen;response to vitamin D;translesion synthesis;viral process","cadherin binding;DNA binding transcription factor activity;ligase activity;RNA binding;ubiquitin protein ligase activity involved in ERAD pathway;ubiquitin-protein transferase activity;zinc ion binding","cytosol;nuclear body;nucleoplasm","Influenza A;NF-kappa B signaling pathway;RIG-I-like receptor signaling pathway",null,null,17,17,17,"27.1","27.1","27.1","70.973",0,"51.962",973250000,65,"0.0621902",1,"0.056242","0.190383","sp|Q14258|TRI25_HUMAN","sp|Q14258|TRI25_HUMAN",2354,"Q14258","TRI25_HUMAN","E3 ubiquitin/ISG15 ligase TRIM25",null,"TRIM25"]
["21.458","21.3137","21.3979","21.2619",{"$nulls":3},"intracellular protein transport;regulation of Arp2/3 complex-mediated actin nucleation;regulation of protein secretion","cadherin binding;phosphatidylinositol-4-phosphate binding;protein domain specific binding","cytosol;Golgi membrane;trans-Golgi network membrane",{"$nulls":3},13,13,13,"52.8","52.8","52.8","41.738",0,"80.242",458410000,42,"0.201216",1,"0.0559845","0.564653","sp|P53367|ARFP1_HUMAN","sp|P53367|ARFP1_HUMAN",1709,"P53367","ARFP1_HUMAN","Arfaptin-1",null,"ARFIP1"]
["23.5793","24.0367","23.8991","23.6063",{"$nulls":3},"heme catabolic process","biliverdin reductase activity;riboflavin reductase (NADPH) activity","cytosol;extracellular exosome;nucleoplasm;plasma membrane;terminal bouton","Metabolic pathways;Porphyrin and chlorophyll metabolism;Riboflavin metabolism",null,null,9,9,9,"61.2","61.2","61.2","22.119",0,"59.582",1258100000,75,"0.0668585",1,"0.0553627","0.20387","sp|P30043|BLVRB_HUMAN;tr|M0R192|M0R192_HUMAN;tr|M0QZL1|M0QZL1_HUMAN","sp|P30043|BLVRB_HUMAN;tr|M0R192|M0R192_HUMAN",1293,"P30043","BLVRB_HUMAN","Flavin reductase (NADPH)","R","BLVRB"]
["16.5453",1,"16.4363",1,{"$nulls":3},"post-translational protein modification;protein ubiquitination",null,"Cul4-RING E3 ubiquitin ligase complex;cytoplasm;cytosol;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"5.9","5.9","5.9","66.851","0.00069606","4.8112",21944000,5,"0.0015309",1,"0.0545101","0.00497639","sp|Q5TAQ9|DCAF8_HUMAN;tr|G3V3G9|G3V3G9_HUMAN;tr|V9GY54|V9GY54_HUMAN;tr|Q5TAQ8|Q5TAQ8_HUMAN","sp|Q5TAQ9|DCAF8_HUMAN;tr|G3V3G9|G3V3G9_HUMAN;tr|V9GY54|V9GY54_HUMAN",2737,"Q5TAQ9","DCAF8_HUMAN","DDB1- and CUL4-associated factor 8",null,"DCAF8"]
["15.3989",1,"15.2903",1,{"$nulls":3},"RNA processing","RNA binding",{"$nulls":4},2,2,2,"2.7","2.7","2.7","93.859","0.0023148","3.3306",38831000,2,"0.00164708",1,"0.0543003","0.00535333","tr|M0R3F6|M0R3F6_HUMAN;sp|Q8IX01|SUGP2_HUMAN;tr|M0R2Z9|M0R2Z9_HUMAN","tr|M0R3F6|M0R3F6_HUMAN;sp|Q8IX01|SUGP2_HUMAN;tr|M0R2Z9|M0R2Z9_HUMAN",3141,"M0R3F6","M0R3F6_HUMAN",null,null,"SUGP2"]
["20.4482","20.1674","20.3641","20.1442",{"$nulls":3},"sphingolipid metabolic process","glucosylceramidase activity",{"$nulls":4},8,8,8,"28.7","28.7","28.7","50.263",0,"49.988",250370000,23,"0.101331",1,"0.0536537","0.300889","tr|A0A0G2JNZ5|A0A0G2JNZ5_HUMAN;tr|A0A0G2JLB3|A0A0G2JLB3_HUMAN;sp|P04062|GLCM_HUMAN;tr|A0A0G2JNZ0|A0A0G2JNZ0_HUMAN","tr|A0A0G2JNZ5|A0A0G2JNZ5_HUMAN;tr|A0A0G2JLB3|A0A0G2JLB3_HUMAN;sp|P04062|GLCM_HUMAN;tr|A0A0G2JNZ0|A0A0G2JNZ0_HUMAN",830,"A0A0G2JNZ5","A0A0G2JNZ5_HUMAN","Glucosylceramidase {ECO:0000256|RuleBase:RU361188}",null,"GBA"]
["19.3624","19.5822","19.7852","19.0545",{"$nulls":3},"myosin filament assembly;negative regulation of endoplasmic reticulum calcium ion concentration;positive regulation of GTPase activity;positive regulation of mitochondrial calcium ion concentration;small GTPase mediated signal transduction;vascular smooth muscle contraction","GTPase activator activity","cytosol;endoplasmic reticulum;extracellular exosome;mitochondrion",{"$nulls":3},5,5,5,"10.7","10.7","10.7","66.316",0,"21.778",184040000,16,"0.0441946",1,"0.0524549","0.137478","sp|P52306|GDS1_HUMAN;tr|D6RHH8|D6RHH8_HUMAN;tr|D6RB97|D6RB97_HUMAN;tr|D6REZ0|D6REZ0_HUMAN;tr|H0Y8M2|H0Y8M2_HUMAN","sp|P52306|GDS1_HUMAN",1683,"P52306","GDS1_HUMAN","Rap1 GTPase-GDP dissociation stimulator 1",null,"RAP1GDS1"]
["20.7257","21.044","20.7315","20.9337",{"$nulls":3},"eye photoreceptor cell development;response to high light intensity;retina layer formation","NADP-retinol dehydrogenase activity","mitochondrial inner membrane",{"$nulls":3},9,9,9,35,35,35,"35.932",0,"73.396",285510000,32,"0.0927736",1,"0.0522652","0.277191","sp|Q8NBN7|RDH13_HUMAN;tr|G8JLA1|G8JLA1_HUMAN;tr|K7EQB5|K7EQB5_HUMAN;tr|K7ERV1|K7ERV1_HUMAN","sp|Q8NBN7|RDH13_HUMAN",3289,"Q8NBN7","RDH13_HUMAN","Retinol dehydrogenase 13",null,"RDH13"]
["24.0545","24.8124","24.315","24.4477",{"$nulls":3},"acetyl-CoA biosynthetic process;acetyl-CoA catabolic process;adipose tissue development;brain development;branched-chain amino acid catabolic process;coenzyme A biosynthetic process;coenzyme A metabolic process;fatty acid beta-oxidation;isoleucine catabolic process;ketone body biosynthetic process;ketone body catabolic process;ketone body metabolic process;liver development;metanephric proximal convoluted tubule development;propionyl-CoA biosynthetic process;protein homooligomerization;response to hormone;response to organic cyclic compound;response to starvation","acetyl-CoA C-acetyltransferase activity;carbon-carbon lyase activity;coenzyme binding;enzyme binding;ligase activity, forming carbon-carbon bonds;metal ion binding;protein homodimerization activity","extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Butanoate metabolism;Carbon metabolism;Fatty acid degradation;Fatty acid metabolism;Glyoxylate and dicarboxylate metabolism;Lysine degradation;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism;Synthesis and degradation of ketone bodies;Terpenoid backbone biosynthesis;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,19,19,19,"57.1","57.1","57.1","45.199",0,"323.31",4414800000,157,"0.0434988",1,"0.0520916","0.135401","sp|P24752|THIL_HUMAN;tr|H0YEL7|H0YEL7_HUMAN;tr|E9PRQ6|E9PRQ6_HUMAN;tr|E9PKF3|E9PKF3_HUMAN","sp|P24752|THIL_HUMAN",1214,"P24752","THIL_HUMAN","Acetyl-CoA acetyltransferase, mitochondrial",null,"ACAT1"]
["20.7833","20.564","21.03","20.2148",{"$nulls":3},"cis assembly of pre-catalytic spliceosome;mRNA splicing, via spliceosome;osteoblast differentiation","ATP binding;ATP-dependent helicase activity;ATP-dependent RNA helicase activity;identical protein binding;RNA binding","catalytic step 2 spliceosome;membrane;nucleoplasm;nucleus;spliceosomal complex;U4/U6 x U5 tri-snRNP complex;U5 snRNP","Spliceosome",null,null,82,82,82,"46.1","46.1","46.1","244.5",0,"323.31",9985200000,775,"0.0388683",1,"0.0512915","0.121516","sp|O75643|U520_HUMAN;tr|B4E0P5|B4E0P5_HUMAN","sp|O75643|U520_HUMAN",596,"O75643","U520_HUMAN","U5 small nuclear ribonucleoprotein 200 kDa helicase",null,"SNRNP200"]
["20.7483","20.7518","21.2638","20.1361",{"$nulls":3},"carbohydrate metabolic process;glycerol-3-phosphate catabolic process;NAD metabolic process;NADH metabolic process;negative regulation of peptidyl-serine phosphorylation;negative regulation of protein kinase C signaling;phosphatidic acid biosynthetic process;positive regulation of protein localization to cell surface;positive regulation of sodium ion transport;regulation of heart rate;regulation of sodium ion transmembrane transporter activity;regulation of ventricular cardiac muscle cell membrane depolarization;ventricular cardiac muscle cell action potential","glycerol-3-phosphate dehydrogenase [NAD+] activity;ion channel binding;NAD binding;protein homodimerization activity;sodium channel regulator activity","cytosol;extracellular exosome;glycerol-3-phosphate dehydrogenase complex;plasma membrane","Glycerophospholipid metabolism",null,null,8,8,7,"20.2","20.2","18.2","38.418",0,"24.996",424630000,26,"0.0281303",1,"0.0501118","0.0888735","sp|Q8N335|GPD1L_HUMAN;tr|C9K0P5|C9K0P5_HUMAN;tr|C9JFA7|C9JFA7_HUMAN;tr|C9JM46|C9JM46_HUMAN","sp|Q8N335|GPD1L_HUMAN;tr|C9K0P5|C9K0P5_HUMAN;tr|C9JFA7|C9JFA7_HUMAN",3211,"Q8N335","GPD1L_HUMAN","Glycerol-3-phosphate dehydrogenase 1-like protein","PD1-L","GPD1L"]
["23.895","23.1479","23.8006","23.1461",{"$nulls":3},"cytoplasmic translational initiation;translational initiation","translation initiation factor activity;translation initiation factor binding","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m",{"$nulls":3},13,13,13,"48.9","48.9","48.9","42.502",0,"263.92",1823800000,62,"0.0307653",1,"0.0481462","0.0969433","sp|Q7L2H7|EIF3M_HUMAN;tr|H0YCQ8|H0YCQ8_HUMAN;tr|J3KNJ2|J3KNJ2_HUMAN;tr|E9PRY0|E9PRY0_HUMAN;tr|E9PN86|E9PN86_HUMAN;tr|E9PRI2|E9PRI2_HUMAN;tr|E7ESM3|E7ESM3_HUMAN","sp|Q7L2H7|EIF3M_HUMAN;tr|H0YCQ8|H0YCQ8_HUMAN;tr|J3KNJ2|J3KNJ2_HUMAN",2963,"Q7L2H7","EIF3M_HUMAN","Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012}","IF3m {ECO:0000255|HAMAP-Rule:MF_03012}","EIF3M"]
["16.1423","15.3631","16.495","14.9147",{"$nulls":4},"growth factor activity;hydrolase activity","mitochondrion;nucleus",{"$nulls":3},1,1,1,"3.2","3.2","3.2","35.678","0.003736","3.1405",10897000,6,"0.0170071",1,"0.0478816","0.0543508","sp|P53370|NUDT6_HUMAN","sp|P53370|NUDT6_HUMAN",1710,"P53370","NUDT6_HUMAN","Nucleoside diphosphate-linked moiety X motif 6","udix motif 6","NUDT6"]
["19.6096","20.69","20.0094","20.1971",{"$nulls":3},"protein import into nucleus;regulation of gene silencing by miRNA;signal transduction","protein transporter activity;Ran GTPase binding","cytosol;nuclear envelope;nucleoplasm",{"$nulls":3},9,9,9,"11.5","11.5","11.5","119.94",0,"55.44",549790000,44,"0.0268545",1,"0.0465803","0.0849515","sp|O15397|IPO8_HUMAN;tr|F5H2I3|F5H2I3_HUMAN;tr|H0YH64|H0YH64_HUMAN;tr|F5H244|F5H244_HUMAN","sp|O15397|IPO8_HUMAN",361,"O15397","IPO8_HUMAN","Importin-8","mp8","IPO8"]
["20.6201","19.2505","20.8121","18.9665",{"$nulls":3},"metabolic process","hydrolase activity","mitochondrion",{"$nulls":3},4,4,4,"25.5","25.5","25.5",28,0,"12.411",96546000,9,"0.012455",1,"0.0459623","0.0399976","sp|Q9BSH5|HDHD3_HUMAN","sp|Q9BSH5|HDHD3_HUMAN",3949,"Q9BSH5","HDHD3_HUMAN","Haloacid dehalogenase-like hydrolase domain-containing protein 3",null,"HDHD3"]
["21.2797","18.4964","20.9282","18.757",{"$nulls":3},"apoptotic process;autophagy;cellular response to cobalt ion;cellular response to DNA damage stimulus;cellular response to hypoxia;fructose 1,6-bisphosphate metabolic process;fructose 2,6-bisphosphate metabolic process;intestinal epithelial cell development;negative regulation of glucose catabolic process to lactate via pyruvate;negative regulation of glycolytic process;negative regulation of mitophagy;negative regulation of neuron death;negative regulation of programmed cell death;negative regulation of reactive oxygen species metabolic process;positive regulation of cardiac muscle cell apoptotic process;positive regulation of DNA repair;positive regulation of hexokinase activity;regulation of pentose-phosphate shunt;regulation of response to DNA damage checkpoint signaling;response to gamma radiation;response to ischemia;response to xenobiotic stimulus","bisphosphoglycerate 2-phosphatase activity;fructose-2,6-bisphosphate 2-phosphatase activity","cytoplasm;cytosol;intracellular;mitochondrial outer membrane;nucleus","Central carbon metabolism in cancer;Fructose and mannose metabolism;Metabolic pathways",null,null,5,5,5,"25.6","25.6","25.6","30.062",0,"15.06",249600000,16,"0.00798037",1,"0.0454559","0.0257538","sp|Q9NQ88|TIGAR_HUMAN","sp|Q9NQ88|TIGAR_HUMAN",4382,"Q9NQ88","TIGAR_HUMAN","Fructose-2,6-bisphosphatase TIGAR {ECO:0000305}",null,"TIGAR"]
["22.6406","22.8198","22.7486","22.6219",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent protein catabolic process;Wnt signaling pathway, planar cell polarity pathway","enzyme regulator activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, lid subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,17,17,17,"38.2","38.2","38.2","60.977",0,"165.68",2112700000,105,"0.141724",1,"0.0449886","0.409978","sp|O43242|PSMD3_HUMAN;tr|F5H8K4|F5H8K4_HUMAN","sp|O43242|PSMD3_HUMAN",382,"O43242","PSMD3_HUMAN","26S proteasome non-ATPase regulatory subunit 3",null,"PSMD3"]
["17.9266","18.7872","18.9889","17.6373",{"$nulls":3},"fatty acid transport;lipid metabolic process;long-chain fatty acid import;long-chain fatty acid metabolic process;long-chain fatty acid transport;medium-chain fatty acid transport;response to nutrient;skin development;transport;very long-chain fatty acid catabolic process","fatty acid transmembrane transporter activity;long-chain fatty acid-CoA ligase activity;nucleotide binding;very long-chain fatty acid-CoA ligase activity","brush border membrane;endoplasmic reticulum membrane;integral component of membrane;membrane;microvillus;plasma membrane","Fat digestion and absorption;Insulin resistance;PPAR signaling pathway",null,null,9,9,9,"17.3","17.3","17.3","72.063",0,"25.024",261530000,38,"0.0171061",1,"0.0437937","0.0546613","sp|Q6P1M0|S27A4_HUMAN","sp|Q6P1M0|S27A4_HUMAN",2851,"Q6P1M0","S27A4_HUMAN","Long-chain fatty acid transport protein 4","ATP-4;atty acid transport protein 4","SLC27A4"]
["21.4198","21.3004","21.4844","21.1492",{"$nulls":3},"cell differentiation;chaperone-mediated protein folding;muscle organ development","cadherin binding;Hsp90 protein binding","cytosol;Golgi apparatus;nuclear speck;perinuclear region of cytoplasm",{"$nulls":3},28,28,28,"34.7","34.7","34.7","103.08",0,"278.3",2061500000,211,"0.0807167",1,"0.0432987","0.243388","sp|Q9H3U1|UN45A_HUMAN","sp|Q9H3U1|UN45A_HUMAN",4196,"Q9H3U1","UN45A_HUMAN","Protein unc-45 homolog A","nc-45A","UNC45A"]
["25.2557","25.8292","25.3397","25.6628",{"$nulls":3},"apoptotic process;cell division;cellular response to DNA damage stimulus;cellular response to hydrogen peroxide;cellular response to tumor necrosis factor;chromosome segregation;cytoplasmic translation;DNA damage response, detection of DNA damage;DNA repair;negative regulation of DNA repair;negative regulation of protein ubiquitination;negative regulation of translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of activated T cell proliferation;positive regulation of apoptotic signaling pathway;positive regulation of base-excision repair;positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis;positive regulation of DNA N-glycosylase activity;positive regulation of DNA repair;positive regulation of endodeoxyribonuclease activity;positive regulation of gene expression;positive regulation of interleukin-2 production;positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage;positive regulation of JUN kinase activity;positive regulation of microtubule polymerization;positive regulation of NF-kappaB transcription factor activity;positive regulation of NIK/NF-kappaB signaling;positive regulation of protein complex assembly;positive regulation of T cell receptor signaling pathway;regulation of apoptotic process;response to oxidative stress;response to TNF agonist;rRNA processing;spindle assembly;SRP-dependent cotranslational protein targeting to membrane;transcription, DNA-templated;translation;translational initiation;viral transcription","class I DNA-(apurinic or apyrimidinic site) lyase activity;class III/IV DNA-(apurinic or apyrimidinic site) lyase activity;damaged DNA binding;DNA binding;DNA-(apurinic or apyrimidinic site) lyase activity;endodeoxyribonuclease activity;enzyme binding;Hsp70 protein binding;Hsp90 protein binding;iron-sulfur cluster binding;kinase binding;microtubule binding;mRNA binding;oxidized purine DNA binding;oxidized pyrimidine DNA binding;protein complex binding;protein kinase A binding;protein kinase binding;RNA binding;small ribosomal subunit rRNA binding;structural constituent of ribosome;supercoiled DNA binding;transcription factor binding;tubulin binding;ubiquitin-like protein conjugating enzyme binding","cytoplasm;cytosol;cytosolic small ribosomal subunit;endoplasmic reticulum;extracellular exosome;extracellular matrix;focal adhesion;intracellular ribonucleoprotein complex;membrane;mitochondrial inner membrane;mitochondrial matrix;mitotic spindle;NF-kappaB complex;nucleolus;nucleoplasm;nucleus;plasma membrane;polysome;ribosome;ruffle membrane","Ribosome",null,null,23,23,23,"77.8","77.8","77.8","26.688",0,"323.31",62859000000,1351,"0.0400478",1,"0.0411663","0.125064","sp|P23396|RS3_HUMAN;tr|E9PL09|E9PL09_HUMAN;tr|E9PPU1|E9PPU1_HUMAN;tr|F2Z2S8|F2Z2S8_HUMAN;tr|H0YCJ7|H0YCJ7_HUMAN;tr|H0YEU2|H0YEU2_HUMAN;tr|H0YF32|H0YF32_HUMAN;tr|E9PQ96|E9PQ96_HUMAN;tr|E9PJH4|E9PJH4_HUMAN;tr|E9PK82|E9PK82_HUMAN;tr|E9PSF4|E9PSF4_HUMAN;tr|E9PQX2|E9PQX2_HUMAN;tr|H0YES8|H0YES8_HUMAN;tr|E9PJN9|E9PJN9_HUMAN","sp|P23396|RS3_HUMAN;tr|E9PL09|E9PL09_HUMAN;tr|E9PPU1|E9PPU1_HUMAN;tr|F2Z2S8|F2Z2S8_HUMAN;tr|H0YCJ7|H0YCJ7_HUMAN;tr|H0YEU2|H0YEU2_HUMAN;tr|H0YF32|H0YF32_HUMAN",1198,"P23396","RS3_HUMAN","40S ribosomal protein S3",null,"RPS3"]
["23.7137","23.5534","23.7509","23.4343",{"$nulls":4},"ATP binding;helicase activity;nucleic acid binding",{"$nulls":4},29,29,22,"48.5","48.5","38.3","69.086",0,"323.31",4187500000,200,"0.0762642",1,"0.0409479","0.230772","tr|J3KTA4|J3KTA4_HUMAN;sp|P17844|DDX5_HUMAN;tr|J3QRQ7|J3QRQ7_HUMAN;tr|J3QSF1|J3QSF1_HUMAN;tr|J3KRZ1|J3KRZ1_HUMAN;tr|J3KRX8|J3KRX8_HUMAN;tr|J3QR02|J3QR02_HUMAN;tr|X6RLV5|X6RLV5_HUMAN;tr|J3QRN5|J3QRN5_HUMAN;tr|J3QLG9|J3QLG9_HUMAN;tr|J3QR62|J3QR62_HUMAN","tr|J3KTA4|J3KTA4_HUMAN;sp|P17844|DDX5_HUMAN",1105,"J3KTA4","J3KTA4_HUMAN",null,null,"DDX5"]
["23.1953","23.0022","23.3987","22.7175",{"$nulls":3},"defense response to virus;negative regulation of transcription, DNA-templated;negative regulation of translation;negative regulation of viral genome replication;positive regulation of transcription, DNA-templated;protein phosphorylation;transcription, DNA-templated","DNA binding;double-stranded RNA binding;RNA binding","cytoplasm;extracellular region;intracellular ribonucleoprotein complex;membrane;mitochondrion;nucleolus;nucleoplasm;nucleus",{"$nulls":3},31,31,27,"45.5","45.5","41.7","95.337",0,"258.92",3127200000,194,"0.0366287",1,"0.0406265","0.11476","sp|Q12906|ILF3_HUMAN;tr|K7EKJ9|K7EKJ9_HUMAN;tr|K7EQR9|K7EQR9_HUMAN;tr|K7ER69|K7ER69_HUMAN;tr|K7EKY0|K7EKY0_HUMAN;tr|K7ERM6|K7ERM6_HUMAN;tr|K7ENK6|K7ENK6_HUMAN;tr|K7EM82|K7EM82_HUMAN;tr|K7EJ09|K7EJ09_HUMAN;tr|K7EPG3|K7EPG3_HUMAN;tr|K7EQ75|K7EQ75_HUMAN","sp|Q12906|ILF3_HUMAN",2177,"Q12906","ILF3_HUMAN","Interleukin enhancer-binding factor 3",null,"ILF3"]
["21.8058","21.912","21.9925","21.6464",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell division;ciliary basal body-plasma membrane docking;cytoplasmic microtubule organization;cytoplasmic mRNA processing body assembly;ER to Golgi vesicle-mediated transport;establishment of spindle localization;G2/M transition of mitotic cell cycle;minus-end-directed vesicle transport along microtubule;mitotic spindle organization;neutrophil degranulation;positive regulation of intracellular transport;positive regulation of spindle assembly;regulation of G2/M transition of mitotic cell cycle;regulation of metaphase plate congression;regulation of mitotic spindle organization;sister chromatid cohesion;stress granule assembly","ATP binding;ATPase activity;dynein intermediate chain binding;dynein light chain binding;dynein light intermediate chain binding;microtubule motor activity;RNA binding","azurophil granule lumen;centrosome;cytoplasmic dynein complex;cytosol;extracellular exosome;extracellular matrix;extracellular region;filopodium;membrane;microtubule","Phagosome;Salmonella infection;Vasopressin-regulated water reabsorption",null,null,142,142,142,"37.4","37.4","37.4","532.4",0,"323.31",8534400000,515,"0.0717753",1,"0.039464","0.217977","sp|Q14204|DYHC1_HUMAN;tr|H0YJ21|H0YJ21_HUMAN","sp|Q14204|DYHC1_HUMAN",2347,"Q14204","DYHC1_HUMAN","Cytoplasmic dynein 1 heavy chain 1",null,"DYNC1H1"]
["19.0821",1,"19.0034",1,{"$nulls":3},"transcription, DNA-templated;transforming growth factor beta receptor signaling pathway","DNA binding;DNA binding transcription factor activity","cytoplasm;integral component of membrane;nucleus;transcription factor complex",{"$nulls":3},2,1,1,"8.8","5.8","5.8","48.669","0.00026035","7.2178",65910000,6,"0.000947105",1,"0.0393047","0.00308075","tr|B7Z5N5|B7Z5N5_HUMAN;sp|Q15796|SMAD2_HUMAN","tr|B7Z5N5|B7Z5N5_HUMAN;sp|Q15796|SMAD2_HUMAN",2522,"B7Z5N5","B7Z5N5_HUMAN","Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195}","AD homolog {ECO:0000256|RuleBase:RU361195};others against DPP homolog {ECO:0000256|RuleBase:RU361195}","SMAD2"]
["23.487","23.7276","23.9989","23.1375",{"$nulls":3},"cellular protein modification process;NIK/NF-kappaB signaling;positive regulation of neuron apoptotic process;post-translational protein modification;protein neddylation;transforming growth factor beta receptor signaling pathway","ATP binding;NEDD8 transferase activity;ribosomal S6-glutamic acid ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm","Ubiquitin mediated proteolysis",null,null,8,8,8,"42.1","42.1","42.1","20.9",0,"42.141",1118400000,51,"0.0277131",1,"0.0391703","0.0875919","sp|P61081|UBC12_HUMAN;tr|M0QX69|M0QX69_HUMAN;tr|M0QYI6|M0QYI6_HUMAN","sp|P61081|UBC12_HUMAN",1828,"P61081","UBC12_HUMAN","NEDD8-conjugating enzyme Ubc12",null,"UBE2M"]
["22.2443","21.4055","22.2829","21.2894",{"$nulls":3},"circadian rhythm;mRNA destabilization;mRNA processing;mRNA splicing, via spliceosome;negative regulation of catalytic activity;RNA metabolic process","mRNA 3'-UTR binding;RNA binding","axon terminus;catalytic step 2 spliceosome;dendrite;endoplasmic reticulum;growth cone;intracellular ribonucleoprotein complex;nucleoplasm;spliceosomal complex",{"$nulls":3},16,12,12,"31.3","25.1","25.1","70.942",0,"105.78",1564400000,43,"0.0186817",1,"0.0387449","0.0595971","sp|O43390|HNRPR_HUMAN;tr|B4DT28|B4DT28_HUMAN","sp|O43390|HNRPR_HUMAN;tr|B4DT28|B4DT28_HUMAN",394,"O43390","HNRPR_HUMAN","Heterogeneous nuclear ribonucleoprotein R","nRNP R","HNRNPR"]
["19.6691","19.8146","19.9744","19.4328",{"$nulls":4},"methyltransferase activity","integral component of membrane;lipid droplet",{"$nulls":3},3,3,3,"23.3","23.3","23.3","20.662",0,"12.118",63538000,3,"0.043916",1,"0.0383158","0.136646","tr|F8VQX6|F8VQX6_HUMAN;tr|H0YI09|H0YI09_HUMAN;sp|Q9H8H3|MET7A_HUMAN","tr|F8VQX6|F8VQX6_HUMAN;tr|H0YI09|H0YI09_HUMAN;sp|Q9H8H3|MET7A_HUMAN",4256,"F8VQX6","F8VQX6_HUMAN",null,null,"METTL7A"]
["25.1284","25.4811","25.2972","25.2369",{"$nulls":3},"cell proliferation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;ribosomal small subunit assembly;rRNA processing;sister chromatid cohesion;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","DNA binding;RNA binding;structural constituent of ribosome;zinc ion binding","cytosol;cytosolic small ribosomal subunit;nucleoplasm;nucleus;ribosome","Ribosome",null,null,5,5,2,"40.5","40.5","14.3","9.461",0,"54.516",17036000000,596,"0.0691972",1,"0.0376749","0.210592","sp|P42677|RS27_HUMAN;tr|Q5T4L4|Q5T4L4_HUMAN","sp|P42677|RS27_HUMAN;tr|Q5T4L4|Q5T4L4_HUMAN",1476,"P42677","RS27_HUMAN","40S ribosomal protein S27",null,"RPS27"]
["25.6436","25.5503","25.8559","25.2634",{"$nulls":3},"cell cycle phase transition;cell proliferation;cellular protein modification process;cellular response to glucocorticoid stimulus;cellular response to steroid hormone stimulus;positive regulation of protein targeting to mitochondrion;positive regulation of protein ubiquitination;positive regulation of ubiquitin-protein transferase activity;protein K11-linked ubiquitination;protein polyubiquitination;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated;ubiquitin-dependent protein catabolic process","ATP binding;enzyme binding;RNA binding;transcription coactivator activity;ubiquitin conjugating enzyme activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activator activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;ubiquitin ligase complex","Parkinson disease;Ubiquitin mediated proteolysis",null,null,7,7,7,61,61,61,"17.861",0,"264.49",2748700000,75,"0.0398473",1,"0.037323","0.124461","sp|P68036|UB2L3_HUMAN;tr|A0A0B4J2G9|A0A0B4J2G9_HUMAN","sp|P68036|UB2L3_HUMAN;tr|A0A0B4J2G9|A0A0B4J2G9_HUMAN",1958,"P68036","UB2L3_HUMAN","Ubiquitin-conjugating enzyme E2 L3",null,"UBE2L3"]
["17.2209","17.3142","17.1629","17.2989",{"$nulls":3},"biotin metabolic process;biotin transport;pantothenate metabolic process;pantothenate transmembrane transport;transmembrane transport;transport","sodium-dependent multivitamin transmembrane transporter activity","brush border membrane;integral component of plasma membrane;membrane;plasma membrane;vesicle membrane","Vitamin digestion and absorption",null,null,2,2,2,"4.4","4.4","4.4","68.641","0.00024067","5.5603",31560000,6,"0.155037",1,"0.0367002","0.445103","sp|Q9Y289|SC5A6_HUMAN","sp|Q9Y289|SC5A6_HUMAN",4905,"Q9Y289","SC5A6_HUMAN","Sodium-dependent multivitamin transporter","a(+)-dependent multivitamin transporter","SLC5A6"]
[1,"17.2785",1,"17.207",{"$nulls":9},2,2,2,"20.9","20.9","20.9","11.471","0.00024498","5.868",67736000,8,"0.000957319",1,"0.0357647","0.00311394","sp|Q6ZSJ8|CA122_HUMAN","sp|Q6ZSJ8|CA122_HUMAN",2933,"Q6ZSJ8","CA122_HUMAN","Uncharacterized protein C1orf122",null,"C1orf122"]
["19.5517","19.3239","19.5243","19.2825",{"$nulls":3},"in utero embryonic development;negative regulation of gene expression;positive regulation of fibroblast proliferation;regulation of DNA damage checkpoint;regulation of G2/M transition of mitotic cell cycle;ribonucleotide metabolic process;RNA catabolic process","RNA-DNA hybrid ribonuclease activity","nucleus;ribonuclease H2 complex","DNA replication",null,null,5,5,5,"20.8","20.8","20.8","35.138",0,"22.782",101630000,16,"0.0679544",1,"0.0343904","0.207023","sp|Q5TBB1|RNH2B_HUMAN;tr|A0A087WXR7|A0A087WXR7_HUMAN;tr|A0A087WZJ6|A0A087WZJ6_HUMAN","sp|Q5TBB1|RNH2B_HUMAN;tr|A0A087WXR7|A0A087WXR7_HUMAN",2739,"Q5TBB1","RNH2B_HUMAN","Ribonuclease H2 subunit B","Nase H2 subunit B","RNASEH2B"]
["22.732","21.9325","22.906","21.6898",{"$nulls":3},"protein targeting to mitochondrion","heat shock protein binding","cytosol;integral component of membrane;membrane;mitochondrial outer membrane;nucleoplasm;nucleus",{"$nulls":3},11,11,11,"44.3","44.3","44.3","34.559",0,"128.32",1162400000,58,"0.0147203",1,"0.034317","0.0471574","sp|Q15785|TOM34_HUMAN","sp|Q15785|TOM34_HUMAN",2521,"Q15785","TOM34_HUMAN","Mitochondrial import receptor subunit TOM34","Tom34","TOMM34"]
["23.3411","23.3348","23.6077","23.0003",{"$nulls":3},"exon-exon junction complex disassembly;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;positive regulation of translation","ribosome binding;RNA binding","cell junction;cytosol;exon-exon junction complex;nucleolus;nucleoplasm;nucleus","mRNA surveillance pathway;RNA transport",null,null,9,9,9,"68.6","68.6","68.6","22.655",0,"82.947",1299400000,100,"0.0356266",1,"0.0339327","0.111729","sp|Q9BRP8|WIBG_HUMAN","sp|Q9BRP8|WIBG_HUMAN",3936,"Q9BRP8","PYM1_HUMAN","Partner of Y14 and mago {ECO:0000250|UniProtKB:P82804}",null,"PYM1"]
["22.5602","21.9469","22.9622","21.4781",{"$nulls":3},"activation of MAPK activity;Bergmann glial cell differentiation;cell cycle arrest;cell motility;cellular senescence;cerebellar cortex formation;chemotaxis;epithelial cell proliferation involved in lung morphogenesis;ERK1 and ERK2 cascade;face development;heart development;keratinocyte differentiation;labyrinthine layer development;MAPK cascade;movement of cell or subcellular component;negative regulation of cell proliferation;negative regulation of gene expression;neuron differentiation;peptidyl-threonine phosphorylation;placenta blood vessel development;positive regulation of axonogenesis;positive regulation of ERK1 and ERK2 cascade;positive regulation of gene expression;positive regulation of production of miRNAs involved in gene silencing by miRNA;positive regulation of protein serine/threonine kinase activity;positive regulation of transcription, DNA-templated;protein phosphorylation;proteolysis in other organism;regulation of apoptotic process;regulation of axon regeneration;regulation of early endosome to late endosome transport;regulation of Golgi inheritance;regulation of mitotic cell cycle;regulation of stress-activated MAPK cascade;signal transduction;thymus development;thyroid gland development;trachea formation","ATP binding;MAP kinase kinase activity;protein C-terminus binding;protein kinase activity;protein N-terminus binding;protein serine/threonine kinase activator activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity;signal transducer, downstream of receptor, with protein tyrosine phosphatase activity","cytosol;early endosome;endoplasmic reticulum;extracellular exosome;focal adhesion;Golgi apparatus;late endosome;microtubule organizing center;mitochondrion;nucleus;plasma membrane","Acute myeloid leukemia;Alcoholism;Apelin signaling pathway;Apoptosis;Autophagy - animal;B cell receptor signaling pathway;Bladder cancer;Breast cancer;cAMP signaling pathway;Cellular senescence;Central carbon metabolism in cancer;cGMP-PKG signaling pathway;Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;Cushing syndrome;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Focal adhesion;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Influenza A;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;MicroRNAs in cancer;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-small cell lung cancer;Oocyte meiosis;Osteoclast differentiation;Oxytocin signaling pathway;Pancreatic cancer;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prion diseases;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Serotonergic synapse;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thyroid cancer;Thyroid hormone signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Vascular smooth muscle contraction;VEGF signaling pathway;Yersinia infection",null,null,11,11,8,"41.2","41.2",31,"43.439",0,"87.055",844890000,37,"0.0129452",1,"0.0333614","0.0415498","sp|Q02750|MP2K1_HUMAN;tr|H3BRW9|H3BRW9_HUMAN","sp|Q02750|MP2K1_HUMAN",2069,"Q02750","MP2K1_HUMAN","Dual specificity mitogen-activated protein kinase kinase 1","AP kinase kinase 1;APKK 1;KK1","MAP2K1"]
[1,"16.8555",1,"16.7911",{"$nulls":5},"cytosol;mitochondrion",{"$nulls":3},1,1,1,"4.1","4.1","4.1","31.932","0.0065308","2.5609",5044900,3,"0.000885223",1,"0.0322199","0.00287966","tr|H0YBZ4|H0YBZ4_HUMAN;sp|Q15390|MTFR1_HUMAN","tr|H0YBZ4|H0YBZ4_HUMAN;sp|Q15390|MTFR1_HUMAN",2482,"H0YBZ4","H0YBZ4_HUMAN",null,null,"MTFR1"]
["20.4635","18.8872","20.4229","18.8654",{"$nulls":3},"bundle of His cell-Purkinje myocyte adhesion involved in cell communication;cell adhesion;cornification;desmosome organization;homophilic cell adhesion via plasma membrane adhesion molecules;keratinization;maternal process involved in female pregnancy;Purkinje myocyte development;regulation of heart rate by cardiac conduction;regulation of ventricular cardiac muscle cell action potential;response to progesterone","calcium ion binding;cell adhesion molecule binding;cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication","apical plasma membrane;cell surface;cell-cell junction;cornified envelope;desmosome;extracellular exosome;integral component of membrane;intercalated disc;lateral plasma membrane;plasma membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC)",null,null,17,17,17,"25.8","25.8","25.8","122.29",0,"62.973",545580000,62,"0.00874782",1,"0.0312519","0.0282066","sp|Q14126|DSG2_HUMAN;tr|J3KSI6|J3KSI6_HUMAN","sp|Q14126|DSG2_HUMAN",2329,"Q14126","DSG2_HUMAN","Desmoglein-2",null,"DSG2"]
["20.4408","21.2353","21.0413","20.5734",{"$nulls":9},3,3,3,"35.4","35.4","35.4","11.814",0,"32.492",74032000,10,"0.0209489",1,"0.0307369","0.0666718","tr|H3BQQ6|H3BQQ6_HUMAN;tr|H3BTI2|H3BTI2_HUMAN;tr|H3BTP8|H3BTP8_HUMAN;tr|H3BSY6|H3BSY6_HUMAN;tr|H3BP64|H3BP64_HUMAN;tr|H3BUL4|H3BUL4_HUMAN;tr|H3BMX9|H3BMX9_HUMAN;sp|Q9GZU8|F192A_HUMAN;tr|Q6P4H7|Q6P4H7_HUMAN;tr|H3BSF0|H3BSF0_HUMAN;tr|H3BPH9|H3BPH9_HUMAN;tr|H3BPF9|H3BPF9_HUMAN;tr|H3BN22|H3BN22_HUMAN;tr|H3BU93|H3BU93_HUMAN","tr|H3BQQ6|H3BQQ6_HUMAN;tr|H3BTI2|H3BTI2_HUMAN;tr|H3BTP8|H3BTP8_HUMAN;tr|H3BSY6|H3BSY6_HUMAN;tr|H3BP64|H3BP64_HUMAN;tr|H3BUL4|H3BUL4_HUMAN;tr|H3BMX9|H3BMX9_HUMAN;sp|Q9GZU8|F192A_HUMAN;tr|Q6P4H7|Q6P4H7_HUMAN;tr|H3BSF0|H3BSF0_HUMAN",4120,"H3BQQ6","H3BQQ6_HUMAN",null,null,"FAM192A"]
["20.1144","19.5677","20.996","18.6252",{"$nulls":3},"cellular response to interferon-gamma;intracellular protein transport;long-term synaptic potentiation;organelle fusion;positive regulation of catalytic activity;positive regulation of cell adhesion;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of chemotaxis;positive regulation of eosinophil degranulation;positive regulation of immunoglobulin secretion;positive regulation of insulin secretion involved in cellular response to glucose stimulus;positive regulation of protein localization to cell surface;positive regulation of protein localization to plasma membrane;post-Golgi vesicle-mediated transport;regulation of exocytosis;regulation of extrinsic apoptotic signaling pathway via death domain receptors;response to hydroperoxide;SNARE complex assembly;synaptic vesicle fusion to presynaptic active zone membrane;vesicle docking;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane","SNAP receptor activity;SNARE binding;sphingomyelin phosphodiesterase activator activity","basolateral plasma membrane;cell surface;cytosol;dendritic spine;endosome;extracellular exosome;extracellular space;integral component of membrane;intracellular;lamellipodium;lateral loop;membrane;myelin sheath adaxonal region;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;SNARE complex;somatodendritic compartment;specific granule;storage vacuole;synapse;synaptic vesicle;trans-Golgi network;vacuole","SNARE interactions in vesicular transport;Vasopressin-regulated water reabsorption",null,null,7,7,7,34,34,34,"34.18",0,"22.846",149290000,17,"0.00775142",1,"0.0304394","0.0250213","sp|Q12846|STX4_HUMAN;tr|C9JFM5|C9JFM5_HUMAN;tr|A0A087WWW0|A0A087WWW0_HUMAN","sp|Q12846|STX4_HUMAN",2166,"Q12846","STX4_HUMAN","Syntaxin-4",null,"STX4"]
["20.0458","19.566","20.2149","19.3387",{"$nulls":3},"isoprenoid biosynthetic process","carboxy-lyase activity",{"$nulls":4},8,8,8,"35.8","35.8","35.8","29.378",0,"16.777",154310000,15,"0.0182571",1,"0.0291052","0.0582685","tr|H3BP35|H3BP35_HUMAN;sp|P53602|MVD1_HUMAN;tr|A0A087WV85|A0A087WV85_HUMAN;tr|H3BQ47|H3BQ47_HUMAN;tr|H3BRZ1|H3BRZ1_HUMAN;tr|H3BVC4|H3BVC4_HUMAN","tr|H3BP35|H3BP35_HUMAN;sp|P53602|MVD1_HUMAN",1715,"H3BP35","H3BP35_HUMAN",null,null,"MVD"]
["18.7129","19.7152","19.0041","19.3658",{"$nulls":3},"apoptotic process;cellular response to dsRNA;cellular response to interleukin-1;cellular response to interleukin-6;cellular response to lipopolysaccharide;cellular response to mechanical stimulus;cellular response to nicotine;cellular response to peptide hormone stimulus;cellular response to tumor necrosis factor;Fc-epsilon receptor signaling pathway;I-kappaB kinase/NF-kappaB signaling;inflammatory response;innate immune response;membrane protein intracellular domain proteolysis;negative regulation of apoptotic process;negative regulation of calcidiol 1-monooxygenase activity;negative regulation of cellular protein metabolic process;negative regulation of cholesterol transport;negative regulation of gene expression;negative regulation of inflammatory response;negative regulation of interleukin-12 biosynthetic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of vitamin D biosynthetic process;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of hyaluronan biosynthetic process;positive regulation of lipid storage;positive regulation of macrophage derived foam cell differentiation;positive regulation of miRNA metabolic process;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of type I interferon production;response to muscle stretch;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;T cell receptor signaling pathway;transcription from RNA polymerase II promoter","actinin binding;chromatin binding;DNA binding transcription factor activity;identical protein binding;protein heterodimerization activity;protein homodimerization activity;RNA polymerase II distal enhancer sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor binding;transcription regulatory region DNA binding;transcription regulatory region sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cytoplasm;cytosol;extracellular region;I-kappaB/NF-kappaB complex;mitochondrion;nucleoplasm;nucleus;secretory granule lumen;specific granule lumen","Acute myeloid leukemia;Adipocytokine signaling pathway;AGE-RAGE signaling pathway in diabetic complications;Amoebiasis;Antifolate resistance;Apoptosis;B cell receptor signaling pathway;cAMP signaling pathway;Cellular senescence;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Chronic myeloid leukemia;Cocaine addiction;C-type lectin receptor signaling pathway;Cytosolic DNA-sensing pathway;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fluid shear stress and atherosclerosis;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;IL-17 signaling pathway;Inflammatory bowel disease (IBD);Influenza A;Insulin resistance;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Longevity regulating pathway;MAPK signaling pathway;Measles;MicroRNAs in cancer;Neurotrophin signaling pathway;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Pertussis;PI3K-Akt signaling pathway;Prolactin signaling pathway;Prostate cancer;Ras signaling pathway;Relaxin signaling pathway;RIG-I-like receptor signaling pathway;Salmonella infection;Shigellosis;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Viral carcinogenesis;Yersinia infection",null,null,7,7,7,"9.3","9.3","9.3","105.35",0,"38.013",255780000,22,"0.0170888",1,"0.0290928","0.0546072","sp|P19838|NFKB1_HUMAN;tr|D6RF93|D6RF93_HUMAN;tr|D6RH30|D6RH30_HUMAN","sp|P19838|NFKB1_HUMAN",1140,"P19838","NFKB1_HUMAN","Nuclear factor NF-kappa-B p105 subunit",null,"NFKB1"]
["20.9804","20.8347","21.246","20.5132",{"$nulls":3},"nucleotide-excision repair, DNA damage recognition;post-translational protein modification;protein deneddylation;transcription-coupled nucleotide-excision repair","NEDD8-specific protease activity","cell junction;COP9 signalosome;cytosol;extracellular exosome;nuclear speck;nucleoplasm;nucleus;synaptic vesicle",{"$nulls":3},9,9,9,"33.3","33.3","33.3","46.268",0,"68.479",417610000,30,"0.0236064",1,"0.0279903","0.0749238","sp|Q9BT78|CSN4_HUMAN;tr|D6RAX7|D6RAX7_HUMAN;tr|D6RFN0|D6RFN0_HUMAN;tr|D6RD63|D6RD63_HUMAN","sp|Q9BT78|CSN4_HUMAN;tr|D6RAX7|D6RAX7_HUMAN;tr|D6RFN0|D6RFN0_HUMAN;tr|D6RD63|D6RD63_HUMAN",3960,"Q9BT78","CSN4_HUMAN","COP9 signalosome complex subunit 4","GN4;ignalosome subunit 4","COPS4"]
["26.2519","26.0292","26.5138","25.714",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of peptide antigen via MHC class I;ATF6-mediated unfolded protein response;cardiac muscle cell differentiation;cellular calcium ion homeostasis;cellular response to lithium ion;cellular senescence;chaperone-mediated protein folding;cortical actin cytoskeleton organization;glucocorticoid receptor signaling pathway;negative regulation of cell cycle arrest;negative regulation of intracellular steroid hormone receptor signaling pathway;negative regulation of neuron differentiation;negative regulation of retinoic acid receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;negative regulation of translation;negative regulation of trophoblast cell migration;peptide antigen assembly with MHC class I protein complex;positive regulation of cell cycle;positive regulation of cell proliferation;positive regulation of dendritic cell chemotaxis;positive regulation of DNA replication;positive regulation of endothelial cell migration;positive regulation of gene expression;positive regulation of NIK/NF-kappaB signaling;positive regulation of phagocytosis;positive regulation of substrate adhesion-dependent cell spreading;protein export from nucleus;protein folding;protein folding in endoplasmic reticulum;protein localization to nucleus;protein maturation by protein folding;protein stabilization;receptor-mediated endocytosis;regulation of apoptotic process;regulation of meiotic nuclear division;regulation of transcription, DNA-templated;response to drug;response to estradiol;response to testosterone;sequestering of calcium ion;spermatogenesis;vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane","androgen receptor binding;calcium ion binding;carbohydrate binding;chaperone binding;complement component C1q binding;DNA binding;hormone binding;integrin binding;iron ion binding;mRNA binding;peptide binding;protein binding involved in protein folding;RNA binding;ubiquitin protein ligase binding;unfolded protein binding;zinc ion binding","acrosomal vesicle;cell surface;cytoplasm;cytosol;endocytic vesicle lumen;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment membrane;external side of plasma membrane;extracellular exosome;extracellular region;extracellular space;focal adhesion;Golgi apparatus;integral component of lumenal side of endoplasmic reticulum membrane;intracellular;membrane;MHC class I peptide loading complex;nucleus;perinuclear region of cytoplasm;phagocytic vesicle membrane;polysome;proteinaceous extracellular matrix;sarcoplasmic reticulum lumen;smooth endoplasmic reticulum","Antigen processing and presentation;Chagas disease (American trypanosomiasis);Epstein-Barr virus infection;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human T-cell leukemia virus 1 infection;Phagosome;Protein processing in endoplasmic reticulum",null,null,22,22,22,"74.6","74.6","74.6","48.141",0,"323.31",13918000000,453,"0.0201751",1,"0.0266771","0.0642606","sp|P27797|CALR_HUMAN;tr|K7EJB9|K7EJB9_HUMAN;tr|K7EL50|K7EL50_HUMAN","sp|P27797|CALR_HUMAN;tr|K7EJB9|K7EJB9_HUMAN",1258,"P27797","CALR_HUMAN","Calreticulin",null,"CALR"]
["17.7603","18.2097","18.8422","17.076",{"$nulls":3},"positive regulation of neuron projection development;RNA secondary structure unwinding;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;membrane;nucleolus",{"$nulls":3},17,17,17,"38.6","38.6","38.6","61.589",0,"107.95",1315300000,116,"0.00881466",1,"0.025898","0.02842","sp|Q9NY93|DDX56_HUMAN;tr|G3V0G3|G3V0G3_HUMAN;tr|H7C3E9|H7C3E9_HUMAN;tr|F8WDT8|F8WDT8_HUMAN;tr|F8WEI3|F8WEI3_HUMAN;tr|H7BZN7|H7BZN7_HUMAN","sp|Q9NY93|DDX56_HUMAN;tr|G3V0G3|G3V0G3_HUMAN;tr|H7C3E9|H7C3E9_HUMAN;tr|F8WDT8|F8WDT8_HUMAN",4562,"Q9NY93","DDX56_HUMAN","Probable ATP-dependent RNA helicase DDX56",null,"DDX56"]
["17.9126",1,"17.8611",1,{"$nulls":3},"anterior/posterior pattern specification;camera-type eye morphogenesis;histone H2A monoubiquitination;negative regulation of G0 to G1 transition;negative regulation of transcription, DNA-templated;transcription, DNA-templated","chromatin binding;metal ion binding;transferase activity;ubiquitin-protein transferase activator activity","cytosol;nuclear speck;nucleoplasm;nucleus;PcG protein complex;PRC1 complex;sex chromatin",{"$nulls":3},2,1,1,"7.4","3.9","3.9","42.429","0.00023641","5.1802",23718000,2,"0.000662548",1,"0.0257425","0.00215585","sp|Q06587|RING1_HUMAN","sp|Q06587|RING1_HUMAN",2113,"Q06587","RING1_HUMAN","E3 ubiquitin-protein ligase RING1",null,"RING1"]
["19.7618","20.4129","19.9484","20.1756",{"$nulls":3},"glomerular visceral epithelial cell development;glomerular visceral epithelial cell migration;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;negative regulation of hydrogen peroxide-induced cell death;nuclear envelope organization;nuclear pore complex assembly;poly(A)+ mRNA export from nucleus;positive regulation of SMAD protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;renal system development;SMAD protein signal transduction;tRNA export from nucleus;viral process;viral transcription","structural constituent of nuclear pore","host cell;membrane;nuclear envelope;nuclear membrane;nuclear periphery;nuclear pore","RNA transport",null,null,17,17,17,"25.3","25.3","25.3","93.487",0,"78.285",632020000,80,"0.02318",1,"0.0253763","0.0736026","sp|Q8N1F7|NUP93_HUMAN;tr|H3BVG0|H3BVG0_HUMAN;tr|H3BV11|H3BV11_HUMAN;tr|H3BRI8|H3BRI8_HUMAN;tr|H3BM93|H3BM93_HUMAN;tr|H3BNN5|H3BNN5_HUMAN;tr|H3BRD9|H3BRD9_HUMAN;tr|H3BVE2|H3BVE2_HUMAN;tr|H3BP95|H3BP95_HUMAN;tr|H3BV15|H3BV15_HUMAN;tr|H3BMX0|H3BMX0_HUMAN;tr|H3BPA9|H3BPA9_HUMAN","sp|Q8N1F7|NUP93_HUMAN;tr|H3BVG0|H3BVG0_HUMAN",3198,"Q8N1F7","NUP93_HUMAN","Nuclear pore complex protein Nup93",null,"NUP93"]
["26.4408","26.4648","26.6174","26.2393",{"$nulls":3},"angiogenesis;cellular response to epidermal growth factor stimulus;cellular response to leukemia inhibitory factor;negative regulation of translation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter","DNA topoisomerase binding;identical protein binding;mRNA 5'-UTR binding;protein C-terminus binding;RNA binding;telomeric DNA binding","cell cortex;cytoplasmic ribonucleoprotein granule;extracellular exosome;intracellular ribonucleoprotein complex;membrane;nucleolus;nucleoplasm;nucleus","Pathogenic Escherichia coli infection",null,null,26,26,26,"34.1","34.1","34.1","76.613",0,"323.31",28893000000,416,"0.0414597",1,"0.0244932","0.1293","sp|P19338|NUCL_HUMAN;tr|H7BY16|H7BY16_HUMAN;tr|C9JYW2|C9JYW2_HUMAN;tr|C9JLB1|C9JLB1_HUMAN;tr|C9J1H7|C9J1H7_HUMAN;tr|C9JWL1|C9JWL1_HUMAN","sp|P19338|NUCL_HUMAN;tr|H7BY16|H7BY16_HUMAN",1131,"P19338","NUCL_HUMAN","Nucleolin",null,"NCL"]
["20.6021","19.7575","20.9059","19.4053",{"$nulls":3},"acyl-CoA metabolic process","thiolester hydrolase activity",{"$nulls":4},6,6,6,"26.1","26.1","26.1","43.733",0,"23.168",193530000,17,"0.00872815",1,"0.0242319","0.0281438","tr|G3V4F2|G3V4F2_HUMAN;tr|A0A087X0W7|A0A087X0W7_HUMAN;sp|Q86TX2|ACOT1_HUMAN;tr|A0A087WT95|A0A087WT95_HUMAN;sp|P49753|ACOT2_HUMAN;sp|Q8N9L9|ACOT4_HUMAN","tr|G3V4F2|G3V4F2_HUMAN;tr|A0A087X0W7|A0A087X0W7_HUMAN;sp|Q86TX2|ACOT1_HUMAN;tr|A0A087WT95|A0A087WT95_HUMAN;sp|P49753|ACOT2_HUMAN",3039,"G3V4F2","G3V4F2_HUMAN",null,null,"ACOT1"]
["17.7486","18.31","18.5606","17.4496",{"$nulls":3},"biotin metabolic process;short-chain fatty acid catabolic process","ATP binding;biotin binding;biotin carboxylase activity;enzyme binding;metal ion binding;propionyl-CoA carboxylase activity","cytosol;mitochondrial matrix","Carbon metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Propanoate metabolism;Valine, leucine and isoleucine degradation",null,null,36,36,36,"56.5","56.5","56.5","80.058",0,"131.37",1211600000,126,"0.0121089",1,"0.0242109","0.0389009","sp|P05165|PCCA_HUMAN;tr|H0Y5U0|H0Y5U0_HUMAN;tr|Q5JTW6|Q5JTW6_HUMAN;tr|Q5JVH2|Q5JVH2_HUMAN;tr|H0Y4B9|H0Y4B9_HUMAN;tr|H0Y798|H0Y798_HUMAN","sp|P05165|PCCA_HUMAN",859,"P05165","PCCA_HUMAN","Propionyl-CoA carboxylase alpha chain, mitochondrial","CCase subunit alpha","PCCA"]
["22.6718","22.0918","22.7345","21.9815",{"$nulls":3},"metabolic process","catalytic activity","cytoplasm;extracellular exosome;peroxisome",{"$nulls":3},7,7,7,"27.2","27.2","27.2","32.236",0,"19.779",545580000,22,"0.0156363",1,"0.0237799","0.0500427","sp|Q96CN7|ISOC1_HUMAN;tr|D6RGE2|D6RGE2_HUMAN","sp|Q96CN7|ISOC1_HUMAN;tr|D6RGE2|D6RGE2_HUMAN",3637,"Q96CN7","ISOC1_HUMAN","Isochorismatase domain-containing protein 1",null,"ISOC1"]
["22.7486","21.8409","23.04","21.5026",{"$nulls":3},"mitochondrial membrane organization;protein dephosphorylation;protein import into mitochondrial matrix;release of cytochrome c from mitochondria","interleukin-2 receptor binding;phosphoprotein phosphatase activity;protein serine/threonine phosphatase activity;protein tyrosine phosphatase activity;ribonucleoprotein complex binding;RNA binding","integral component of membrane;mitochondrial inner membrane;mitochondrial inner membrane presequence translocase complex;mitochondrion;nuclear speck;nucleoplasm",{"$nulls":3},7,7,7,"24.1","24.1","24.1","39.646",0,"92.174",1275500000,73,"0.00813557",1,"0.0234337","0.0262502","sp|Q3ZCQ8|TIM50_HUMAN;tr|M0R0C3|M0R0C3_HUMAN;tr|M0R2F8|M0R2F8_HUMAN;tr|M0R047|M0R047_HUMAN;tr|M0QXC3|M0QXC3_HUMAN;tr|M0R2Z3|M0R2Z3_HUMAN;tr|M0R303|M0R303_HUMAN;tr|M0R2D2|M0R2D2_HUMAN;tr|M0R1Y4|M0R1Y4_HUMAN;tr|M0R003|M0R003_HUMAN","sp|Q3ZCQ8|TIM50_HUMAN",2622,"Q3ZCQ8","TIM50_HUMAN","Mitochondrial import inner membrane translocase subunit TIM50",null,"TIMM50"]
["20.2961","20.6573","20.3522","20.5549",{"$nulls":3},"aging;apoptotic DNA fragmentation;cellular response to calcium ion;cellular response to glucose stimulus;cellular response to hypoxia;DNA recombination;in utero embryonic development;neuron death in response to oxidative stress;positive regulation of apoptotic DNA fragmentation;positive regulation of hydrogen peroxide-mediated programmed cell death;response to antibiotic;response to estradiol;response to mechanical stimulus;response to tumor necrosis factor","deoxyribonuclease activity;endonuclease activity;metal ion binding;nucleic acid binding","cytosol;mitochondrion;nucleus;perikaryon","Apoptosis",null,null,3,3,3,"13.5","13.5","13.5","32.62",0,"9.5868",212400000,8,"0.0356886",1,"0.0231733","0.111916","sp|Q14249|NUCG_HUMAN","sp|Q14249|NUCG_HUMAN",2352,"Q14249","NUCG_HUMAN","Endonuclease G, mitochondrial","ndo G","ENDOG"]
["23.5489","23.6665","23.6586","23.5127",{"$nulls":3},"actin crosslink formation;actin filament bundle assembly;actin filament network formation;intestinal D-glucose absorption;positive regulation of multicellular organism growth;positive regulation of protein localization to plasma membrane;regulation of microvillus length;terminal web assembly","actin filament binding;calcium ion binding;structural constituent of cytoskeleton","actin filament;actin filament bundle;brush border;cytoplasm;extracellular exosome;terminal web",{"$nulls":3},26,26,23,"52.1","52.1","46.6","70.253",0,"323.31",3754000000,168,"0.0778733",1,"0.0220604","0.23534","sp|Q14651|PLSI_HUMAN;tr|C9JAM8|C9JAM8_HUMAN;tr|C9J359|C9J359_HUMAN;tr|C9J0F3|C9J0F3_HUMAN;tr|C9JAM3|C9JAM3_HUMAN;tr|C9JVY2|C9JVY2_HUMAN;tr|C9JU08|C9JU08_HUMAN;tr|C9JYI1|C9JYI1_HUMAN","sp|Q14651|PLSI_HUMAN",2373,"Q14651","PLSI_HUMAN","Plastin-1",null,"PLS1"]
["28.2575","28.0833","28.468","27.8294",{"$nulls":3},"anatomical structure morphogenesis;cell cycle;cornification;extrinsic apoptotic signaling pathway;Golgi to plasma membrane CFTR protein transport;hepatocyte apoptotic process;intermediate filament cytoskeleton organization;keratinization;negative regulation of apoptotic process;tumor necrosis factor-mediated signaling pathway;viral process","cadherin binding involved in cell-cell adhesion;RNA binding;scaffold protein binding;structural molecule activity","cell periphery;cell-cell adherens junction;centriolar satellite;cytoplasm;cytosol;extracellular exosome;intermediate filament;keratin filament;microtubule organizing center;nucleolus;perinuclear region of cytoplasm","Estrogen signaling pathway;Pathogenic Escherichia coli infection",null,null,40,40,26,"80.7","80.7","61.4","48.057",0,"323.31",64662000000,1415,"0.0205795",1,"0.0216837","0.0655213","sp|P05783|K1C18_HUMAN;tr|F8VZY9|F8VZY9_HUMAN;CON__H-INV:HIT000015463","sp|P05783|K1C18_HUMAN;tr|F8VZY9|F8VZY9_HUMAN",868,"P05783","K1C18_HUMAN","Keratin, type I cytoskeletal 18",null,"KRT18"]
["21.5439","22.6233","21.3556","22.7711",{"$nulls":3},"blood vessel development;brassinosteroid biosynthetic process;cell differentiation;cholesterol biosynthetic process;cholesterol biosynthetic process via desmosterol;cholesterol biosynthetic process via lathosterol;lung development;multicellular organism growth;post-embryonic development;regulation of cell proliferation;regulation of cholesterol biosynthetic process","7-dehydrocholesterol reductase activity;NADP binding;sterol delta7 reductase activity","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane;nuclear outer membrane","Metabolic pathways;Steroid biosynthesis",null,null,7,7,7,"16.2","16.2","16.2","54.489",0,"24.108",984400000,63,"0.00702887",1,"0.0202103","0.0227071","sp|Q9UBM7|DHCR7_HUMAN;tr|E9PJ54|E9PJ54_HUMAN;tr|E9PM00|E9PM00_HUMAN;tr|E9PRL8|E9PRL8_HUMAN;tr|E9PQ71|E9PQ71_HUMAN;tr|E9PIP9|E9PIP9_HUMAN;tr|H0YE57|H0YE57_HUMAN;tr|E9PLZ2|E9PLZ2_HUMAN","sp|Q9UBM7|DHCR7_HUMAN;tr|E9PJ54|E9PJ54_HUMAN;tr|E9PM00|E9PM00_HUMAN",4666,"Q9UBM7","DHCR7_HUMAN","7-dehydrocholesterol reductase",{"$f":"-DHC reductase","v":{"$error":"#NAME?"}},"DHCR7"]
["16.0231",1,"15.9836",1,{"$nulls":3},"histone H3 acetylation;negative regulation of apoptotic process;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;negative regulation of transcription from RNA polymerase II promoter;positive regulation of cell growth;positive regulation of transcription from RNA polymerase II promoter;protein deubiquitination;protein stabilization;regulation of signal transduction by p53 class mediator;RNA polymerase II transcriptional preinitiation complex assembly;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","protein heterodimerization activity;thiol-dependent ubiquitinyl hydrolase activity;transcription corepressor activity;transcription factor binding;transcription regulatory region DNA binding","nucleoplasm;SAGA complex;transcription factor TFIID complex;transcription factor TFTC complex","Basal transcription factors",null,null,10,4,4,47,"23.5","23.5","27.622",0,"8.3477",79210000,14,"0.000572528",1,"0.0197659","0.00186312","sp|Q9HBM6|TAF9B_HUMAN","sp|Q9HBM6|TAF9B_HUMAN",4313,"Q9HBM6","TAF9B_HUMAN","Transcription initiation factor TFIID subunit 9B",null,"TAF9B"]
["18.9654","18.8803","19.247","18.5592",{"$nulls":3},"DNA damage response, detection of DNA damage;DNA-dependent DNA replication;error-free translesion synthesis;error-prone translesion synthesis;negative regulation of transcription from RNA polymerase II promoter;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of transcription, DNA-templated;telomere maintenance via semi-conservative replication;telomere maintenance via telomerase;transcription, DNA-templated;transcription-coupled nucleotide-excision repair;translesion synthesis","ATP binding;DNA binding;DNA clamp loader activity;double-stranded DNA binding;enzyme activator activity;protein domain specific binding;sequence-specific DNA binding","cytoplasm;DNA replication factor C complex;extracellular exosome;nucleolus;nucleoplasm;nucleus","DNA replication;Mismatch repair;Nucleotide excision repair",null,null,42,42,42,"44.9","44.9","44.9","128.25",0,"323.31",4623600000,415,"0.017855",1,"0.0197525","0.0570094","sp|P35251|RFC1_HUMAN;tr|H0Y8U4|H0Y8U4_HUMAN;tr|H0Y9P8|H0Y9P8_HUMAN;tr|E0CX09|E0CX09_HUMAN;tr|D6RAD2|D6RAD2_HUMAN","sp|P35251|RFC1_HUMAN",1380,"P35251","RFC1_HUMAN","Replication factor C subunit 1",null,"RFC1"]
["18.2403","18.9965","18.2604","18.9385",{"$nulls":5},"extracellular exosome;mitochondrion",{"$nulls":3},4,4,4,24,24,24,"23.39",0,"12.385",29999000,7,"0.0116233",1,"0.0189743","0.0373606","sp|Q7Z4H3|HDDC2_HUMAN;tr|V9GYS5|V9GYS5_HUMAN;tr|V9GZ04|V9GZ04_HUMAN","sp|Q7Z4H3|HDDC2_HUMAN",3003,"Q7Z4H3","HDDC2_HUMAN","HD domain-containing protein 2",null,"HDDC2"]
["20.2346","20.3366","20.5738","19.961",{"$nulls":3},"cellular response to amino acid stimulus;covalent chromatin modification;DNA methylation;DNA methylation involved in embryo development;gene silencing;maintenance of DNA methylation;negative regulation of gene expression, epigenetic;negative regulation of histone H3-K9 methylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of gene expression;positive regulation of histone H3-K4 methylation;positive regulation of methylation-dependent chromatin silencing;Ras protein signal transduction;regulation of cell proliferation;transcription, DNA-templated","DNA (cytosine-5-)-methyltransferase activity;DNA binding;DNA-methyltransferase activity;methyl-CpG binding;promoter-specific chromatin binding;RNA binding;zinc ion binding","nucleoplasm;nucleus;pericentric heterochromatin;replication fork","Cysteine and methionine metabolism;Metabolic pathways;MicroRNAs in cancer",null,null,36,36,36,"25.6","25.6","25.6","183.16",0,"145.48",1050400000,99,"0.0183585",1,"0.0181971","0.0585858","sp|P26358|DNMT1_HUMAN;tr|K7ENW7|K7ENW7_HUMAN;tr|K7EJL0|K7EJL0_HUMAN;tr|K7ENQ6|K7ENQ6_HUMAN;tr|K7ERQ1|K7ERQ1_HUMAN;tr|K7EMU8|K7EMU8_HUMAN;tr|K7EIZ6|K7EIZ6_HUMAN;tr|K7ELB1|K7ELB1_HUMAN","sp|P26358|DNMT1_HUMAN",1237,"P26358","DNMT1_HUMAN","DNA (cytosine-5)-methyltransferase 1","nmt1","DNMT1"]
["21.3102","21.4607","21.7241","21.0109",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},9,9,8,"29.6","29.6","25.2","61.024",0,"201.25",708020000,52,"0.0154221",1,"0.017993","0.0493686","sp|Q7Z5L9|I2BP2_HUMAN","sp|Q7Z5L9|I2BP2_HUMAN",3011,"Q7Z5L9","I2BP2_HUMAN","Interferon regulatory factor 2-binding protein 2","RF-2-binding protein 2;RF-2BP2","IRF2BP2"]
["18.8158","17.5477","19.0322","17.2973",{"$nulls":5},"integral component of membrane",{"$nulls":3},5,5,5,"18.1","18.1","18.1","33.435",0,"68.54",401770000,52,"0.00487764",1,"0.0169716","0.0157954","tr|G3XAN4|G3XAN4_HUMAN;sp|Q15629|TRAM1_HUMAN","tr|G3XAN4|G3XAN4_HUMAN;sp|Q15629|TRAM1_HUMAN",2503,"G3XAN4","G3XAN4_HUMAN"]
["25.4776","25.7403","25.7249","25.4624",{"$nulls":3},"positive regulation of transcription initiation from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter;SMAD protein signal transduction","identical protein binding;RNA binding;single-stranded DNA binding;transcription coactivator activity;transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding","extracellular exosome;nucleolus;nucleus;transcription factor complex",{"$nulls":3},8,8,8,"59.1","59.1","59.1","14.395",0,"202.95",17412000000,434,"0.0260443",1,"0.0153131","0.0824562","sp|P53999|TCP4_HUMAN;tr|D6RC37|D6RC37_HUMAN;tr|D6R970|D6R970_HUMAN","sp|P53999|TCP4_HUMAN",1729,"P53999","TCP4_HUMAN","Activated RNA polymerase II transcriptional coactivator p15",null,"SUB1"]
["22.4228","22.4912","22.5885","22.2959",{"$nulls":3},"mRNA 3'-splice site recognition;mRNA processing;mRNA splicing, via spliceosome;regulation of alternative mRNA splicing, via spliceosome","RNA binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;spliceosomal complex;U2 snRNP;U2-type prespliceosome;U2-type spliceosomal complex","Spliceosome",null,null,26,26,26,"40.6","40.6","40.6","88.885",0,"174.29",2377100000,207,"0.0313339",1,"0.0148249","0.0986796","sp|Q15459|SF3A1_HUMAN;tr|F8WB66|F8WB66_HUMAN;tr|H7C1L2|H7C1L2_HUMAN;tr|F8WC79|F8WC79_HUMAN","sp|Q15459|SF3A1_HUMAN",2494,"Q15459","SF3A1_HUMAN","Splicing factor 3A subunit 1",null,"SF3A1"]
["21.9988","22.5199","22.6056","21.8865",{"$nulls":3},"cartilage development;cell-cell adhesion;cell-matrix adhesion;cellular response to fibroblast growth factor stimulus;extracellular matrix disassembly;extracellular matrix organization;hyaluronan catabolic process;interferon-gamma-mediated signaling pathway;leukocyte migration;monocyte aggregation;negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of DNA damage response, signal transduction by p53 class mediator;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;neutrophil degranulation;positive regulation of ERK1 and ERK2 cascade;positive regulation of heterotypic cell-cell adhesion;positive regulation of monocyte aggregation;positive regulation of peptidyl-serine phosphorylation;positive regulation of peptidyl-tyrosine phosphorylation;regulation of lamellipodium morphogenesis;wound healing, spreading of cells","collagen binding;hyaluronic acid binding","apical plasma membrane;cell projection;cell surface;cytosol;extracellular exosome;focal adhesion;Golgi apparatus;integral component of plasma membrane;lamellipodium membrane;macrophage migration inhibitory factor receptor complex;plasma membrane;secretory granule membrane","ECM-receptor interaction;Epstein-Barr virus infection;Hematopoietic cell lineage;MicroRNAs in cancer;Proteoglycans in cancer;Shigellosis",null,null,8,8,8,"13.7","13.7","13.7","81.537",0,"40.139",1332300000,64,"0.00929593",1,"0.0133009","0.0299558","sp|P16070|CD44_HUMAN;tr|H0YD13|H0YD13_HUMAN;tr|H0Y2P0|H0Y2P0_HUMAN;tr|H0YE40|H0YE40_HUMAN;tr|H0YDW7|H0YDW7_HUMAN;tr|H0YCV9|H0YCV9_HUMAN;tr|H0Y5E4|H0Y5E4_HUMAN;tr|H0YDX6|H0YDX6_HUMAN;tr|H0YD17|H0YD17_HUMAN;tr|E9PKC6|E9PKC6_HUMAN;tr|Q86UZ1|Q86UZ1_HUMAN;tr|H0YF08|H0YF08_HUMAN;tr|H0YD90|H0YD90_HUMAN;tr|J3KN83|J3KN83_HUMAN;tr|H0YEV3|H0YEV3_HUMAN;tr|H0YEU1|H0YEU1_HUMAN","sp|P16070|CD44_HUMAN;tr|H0YD13|H0YD13_HUMAN;tr|H0Y2P0|H0Y2P0_HUMAN;tr|H0YE40|H0YE40_HUMAN;tr|H0YDW7|H0YDW7_HUMAN;tr|H0YCV9|H0YCV9_HUMAN;tr|H0Y5E4|H0Y5E4_HUMAN",1069,"P16070","CD44_HUMAN","CD44 antigen",null,"CD44"]
["18.8333","19.9704","18.9236","19.8541",{"$nulls":3},"negative regulation of transcription, DNA-templated;positive regulation of viral transcription;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","RNA binding","membrane;NELF complex;nucleoplasm",{"$nulls":3},5,5,5,"10.2","10.2","10.2","66.246",0,"11.721",133820000,6,"0.00547945",1,"0.0130272","0.0177323","sp|Q8IXH7|NELFD_HUMAN;tr|X6RLT1|X6RLT1_HUMAN;tr|H0UI80|H0UI80_HUMAN","sp|Q8IXH7|NELFD_HUMAN;tr|X6RLT1|X6RLT1_HUMAN;tr|H0UI80|H0UI80_HUMAN",3144,"Q8IXH7","NELFD_HUMAN","Negative elongation factor C/D","ELF-C/D","NELFCD"]
["19.5479",1,"19.5246",1,{"$nulls":4},"peptidyl-prolyl cis-trans isomerase activity",{"$nulls":4},4,4,4,"15.9","15.9","15.9","19.814",0,"20.027",530550000,36,"0.000273488",1,"0.0116692","0.000890292","tr|F8VU90|F8VU90_HUMAN;sp|Q9NYL4|FKB11_HUMAN;tr|H0YHM7|H0YHM7_HUMAN;tr|E9PAR0|E9PAR0_HUMAN","tr|F8VU90|F8VU90_HUMAN;sp|Q9NYL4|FKB11_HUMAN",4570,"F8VU90","F8VU90_HUMAN","Peptidylprolyl isomerase {ECO:0000256|PROSITE-ProRule:PRU00277}",null,"FKBP11"]
["15.8612",1,"15.8397",1,{"$nulls":5},"nucleoplasm",{"$nulls":3},4,4,4,13,13,13,"35.049","0.00026781","7.8516",135670000,11,"0.000314305",1,"0.0107436","0.00102312","sp|Q8TAV0|FA76A_HUMAN;tr|E9PQL1|E9PQL1_HUMAN;tr|B1AJQ5|B1AJQ5_HUMAN","sp|Q8TAV0|FA76A_HUMAN;tr|E9PQL1|E9PQL1_HUMAN;tr|B1AJQ5|B1AJQ5_HUMAN",3362,"Q8TAV0","FA76A_HUMAN","Protein FAM76A",null,"FAM76A"]
["16.041",1,"16.0228",1,{"$nulls":3},"blood coagulation;lysosome localization;melanocyte differentiation;organelle organization;protein localization to membrane","GTP-dependent protein binding;Rab GTPase binding","BLOC-2 complex;early endosome membrane;endoplasmic reticulum;lysosomal membrane;membrane",{"$nulls":3},1,1,1,"1.8","1.8","1.8","82.974","0.0015152","3.7017",28417000,9,"0.000263543",1,"0.00911903","0.000857927","sp|Q86YV9|HPS6_HUMAN","sp|Q86YV9|HPS6_HUMAN",3097,"Q86YV9","HPS6_HUMAN","Hermansky-Pudlak syndrome 6 protein",null,"HPS6"]
["22.1293","22.0927","22.5686","21.6375",{"$nulls":3},"cellular response to DNA damage stimulus;centrosome cycle;DNA replication;regulation of cell cycle;response to UV;translesion synthesis","chromatin binding","centrosome;nucleoplasm;nucleus;perinuclear region of cytoplasm",{"$nulls":3},4,4,4,"43.2","43.2","43.2","11.986",0,"29.755",287750000,35,"0.00530298",1,"0.00799751","0.0171646","sp|Q15004|PAF15_HUMAN;tr|H0YMA4|H0YMA4_HUMAN;tr|H0YKX3|H0YKX3_HUMAN","sp|Q15004|PAF15_HUMAN;tr|H0YMA4|H0YMA4_HUMAN;tr|H0YKX3|H0YKX3_HUMAN",2417,"Q15004","PAF15_HUMAN","PCNA-associated factor {ECO:0000305}",null,"PCLAF"]
["21.9565","22.0019","21.6469","22.2973",{"$nulls":3},"chromosome segregation;positive regulation of protein dephosphorylation","enzyme regulator activity;protein phosphatase regulator activity","chromosome;cytoplasm;extracellular exosome;nucleus",{"$nulls":3},13,13,13,45,45,45,"41.564",0,"218.57",679250000,45,"0.00669124",1,"0.00704956","0.0216245","sp|Q15435|PP1R7_HUMAN;tr|H7C003|H7C003_HUMAN;tr|C9JD73|C9JD73_HUMAN;tr|C9J177|C9J177_HUMAN;tr|B5MBZ8|B5MBZ8_HUMAN;tr|C9JRC4|C9JRC4_HUMAN;tr|H7C3Q5|H7C3Q5_HUMAN;tr|H7C118|H7C118_HUMAN","sp|Q15435|PP1R7_HUMAN;tr|H7C003|H7C003_HUMAN;tr|C9JD73|C9JD73_HUMAN;tr|C9J177|C9J177_HUMAN;tr|B5MBZ8|B5MBZ8_HUMAN",2491,"Q15435","PP1R7_HUMAN","Protein phosphatase 1 regulatory subunit 7",null,"PPP1R7"]
["22.4895","22.8111","22.5642","22.7238",{"$nulls":3},"cellular response to hypoxia;ER to Golgi vesicle-mediated transport;IRE1-mediated unfolded protein response;negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway;negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;receptor-mediated endocytosis;response to endoplasmic reticulum stress;response to ischemia","ATP binding;chaperone binding","endocytic vesicle lumen;endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;extracellular exosome;extracellular region;focal adhesion;membrane;smooth endoplasmic reticulum","Protein processing in endoplasmic reticulum",null,null,26,26,26,"38.8","38.8","38.8","111.33",0,"323.31",2997600000,159,"0.0108216",1,"0.00624943","0.0348141","sp|Q9Y4L1|HYOU1_HUMAN;tr|A0A087X054|A0A087X054_HUMAN;tr|E9PJ21|E9PJ21_HUMAN;tr|A0A087WWI4|A0A087WWI4_HUMAN;tr|K7EQK2|K7EQK2_HUMAN;tr|J3KTF1|J3KTF1_HUMAN;tr|J3QL06|J3QL06_HUMAN;tr|Q9BST8|Q9BST8_HUMAN;tr|J3QQH7|J3QQH7_HUMAN;tr|J3QLE9|J3QLE9_HUMAN;tr|A0A087X214|A0A087X214_HUMAN;tr|A0A087WW13|A0A087WW13_HUMAN","sp|Q9Y4L1|HYOU1_HUMAN;tr|A0A087X054|A0A087X054_HUMAN;tr|E9PJ21|E9PJ21_HUMAN;tr|A0A087WWI4|A0A087WWI4_HUMAN;tr|K7EQK2|K7EQK2_HUMAN",5018,"Q9Y4L1","HYOU1_HUMAN","Hypoxia up-regulated protein 1",null,"HYOU1"]
["20.4806","19.0479","20.9101","18.6071",{"$nulls":3},"leukotriene metabolic process;response to antineoplastic agent","13-prostaglandin reductase activity;15-oxoprostaglandin 13-oxidase activity;2-alkenal reductase [NAD(P)] activity","cytoplasm;extracellular exosome",{"$nulls":3},5,5,5,"22.2","22.2","22.2","35.869",0,"64.93",120750000,8,"0.00128315",1,"0.00565815","0.00417224","sp|Q14914|PTGR1_HUMAN;tr|F6XGT7|F6XGT7_HUMAN;tr|Q5JVP2|Q5JVP2_HUMAN;tr|F2Z3J9|F2Z3J9_HUMAN","sp|Q14914|PTGR1_HUMAN",2402,"Q14914","PTGR1_HUMAN","Prostaglandin reductase 1","RG-1","PTGR1"]
["17.5772","18.7939","18.1587","18.201",{"$nulls":4},"metal ion binding;zinc ion binding","chromosome, centromeric region;midbody;nucleolus",{"$nulls":3},2,2,2,10,10,10,"36.201","0.0023158","3.3357",30935000,8,"0.00286382",1,"0.00565815","0.00929512","sp|Q9Y3S2|ZN330_HUMAN","sp|Q9Y3S2|ZN330_HUMAN",4996,"Q9Y3S2","ZN330_HUMAN","Zinc finger protein 330",null,"ZNF330"]
["21.5208","21.2236","21.6802","21.0541",{"$nulls":3},"proteolysis","serine-type endopeptidase activity;serine-type exopeptidase activity;serine-type peptidase activity","cytoplasm;cytosol;membrane;nucleus","Renin-angiotensin system",null,null,18,18,18,"37.6","37.6","37.6","80.699",0,"201.61",1058800000,78,"0.00451392",1,"0.00506687","0.0146235","sp|P48147|PPCE_HUMAN","sp|P48147|PPCE_HUMAN",1536,"P48147","PPCE_HUMAN","Prolyl endopeptidase","E","PREP"]
["25.5175","25.6684","25.6098","25.5671",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic small ribosomal subunit;endoplasmic reticulum;extracellular exosome;focal adhesion;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus","Ribosome",null,null,16,16,16,"60.6","60.6","60.6","24.205",0,"323.31",37225000000,693,"0.0177788",1,"0.00444984","0.0567707","sp|P62241|RS8_HUMAN;tr|Q5JR95|Q5JR95_HUMAN","sp|P62241|RS8_HUMAN;tr|Q5JR95|Q5JR95_HUMAN",1875,"P62241","RS8_HUMAN","40S ribosomal protein S8",null,"RPS8"]
["23.1272","23.3065","23.295","23.1315",{"$nulls":3},"DNA replication;DNA replication initiation;G1/S transition of mitotic cell cycle","ATP binding;DNA binding;helicase activity","alpha DNA polymerase:primase complex;centrosome;MCM complex;membrane;nuclear chromosome, telomeric region;nucleoplasm;nucleus;perinuclear region of cytoplasm","Cell cycle;DNA replication",null,null,36,36,36,"52.8","52.8","52.8","90.98",0,"323.31",4741200000,285,"0.00904919",1,"0.00353909","0.0291686","sp|P25205|MCM3_HUMAN;tr|J3KQ69|J3KQ69_HUMAN;tr|Q7Z6P5|Q7Z6P5_HUMAN","sp|P25205|MCM3_HUMAN;tr|J3KQ69|J3KQ69_HUMAN",1217,"P25205","MCM3_HUMAN","DNA replication licensing factor MCM3",null,"MCM3"]
["15.705","15.6081","15.3715","15.9349",{"$nulls":3},"glomerular visceral epithelial cell migration;hematopoietic progenitor cell differentiation;mitotic cytokinesis;positive regulation of bleb assembly;regulation of exit from mitosis;septin ring assembly","actin binding;cadherin binding","actin cytoskeleton;actomyosin contractile ring;bleb;cell cortex region;nucleoplasm",{"$nulls":3},3,3,3,"3.6","3.6","3.6","124.2","0.00024474","5.8565",24200000,5,"0.00357489",1,"0.00331402","0.0115937","sp|Q9NQW6|ANLN_HUMAN;tr|C9JJT6|C9JJT6_HUMAN","sp|Q9NQW6|ANLN_HUMAN",4397,"Q9NQW6","ANLN_HUMAN","Anillin",null,"ANLN"]
["20.9418","20.8014","21.2233","20.5167",{"$nulls":3},"animal organ morphogenesis;cytochrome c-heme linkage;oxidation-reduction process","holocytochrome-c synthase activity;metal ion binding","mitochondrial inner membrane;mitochondrion","Porphyrin and chlorophyll metabolism",null,null,7,7,7,"39.2","39.2","39.2","30.601",0,"26.704",293090000,37,"0.0013721",1,"0.00160694","0.004461","sp|P53701|CCHL_HUMAN","sp|P53701|CCHL_HUMAN",1723,"P53701","CCHL_HUMAN","Cytochrome c-type heme lyase","CHL","HCCS"]
["22.4657","23.0617","22.9274","22.597",{"$nulls":3},"sensory perception of pain","neurotransmitter binding","mitochondrial inner membrane;mitochondrion;synaptic membrane",{"$nulls":3},7,7,7,25,25,25,"33.31",0,"46.404",1012000000,35,"0.00135496",1,"0.00150108","0.00440537","sp|Q9BPW8|NIPS1_HUMAN;tr|C9JDV8|C9JDV8_HUMAN;tr|H7C2U6|H7C2U6_HUMAN;tr|F8WCR5|F8WCR5_HUMAN","sp|Q9BPW8|NIPS1_HUMAN",3901,"Q9BPW8","NIPS1_HUMAN","Protein NipSnap homolog 1","ipSnap1","NIPSNAP1"]
["27.4394","27.8005","27.6914","27.5474",{"$nulls":3},"cellular response to heat;cerebral cortex development;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;hippo signaling;hippocampus development;intracellular signal transduction;MAPK cascade;membrane organization;membrane repolarization during cardiac muscle cell action potential;negative regulation of calcium ion export across plasma membrane;negative regulation of calcium ion transmembrane transporter activity;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of peptidyl-serine dephosphorylation;neuron migration;positive regulation of protein export from nucleus;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;protein targeting;regulation of cellular response to heat;regulation of cytosolic calcium ion concentration;regulation of G2/M transition of mitotic cell cycle;regulation of heart rate by cardiac conduction;regulation of heart rate by hormone;regulation of membrane repolarization;regulation of potassium ion transmembrane transporter activity;substantia nigra development;viral process","cadherin binding;calcium channel regulator activity;enzyme binding;histone deacetylase binding;identical protein binding;ion channel binding;MHC class II protein complex binding;phosphoprotein binding;phosphoserine residue binding;potassium channel regulator activity;protein domain specific binding;protein heterodimerization activity;Rab guanyl-nucleotide exchange factor activity;RNA binding;ubiquitin protein ligase binding","axon;central region of growth cone;cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;focal adhesion;kinesin complex;melanosome;membrane;mitochondrion;nucleus","Cell cycle;Hepatitis C;Hippo signaling pathway;Neurotrophin signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,22,22,19,71,71,"67.8","29.174",0,"323.31",30154000000,537,"0.000935208",1,"0.000591278","0.00304209","sp|P62258|1433E_HUMAN;tr|B4DJF2|B4DJF2_HUMAN;tr|I3L3T1|I3L3T1_HUMAN;tr|K7EM20|K7EM20_HUMAN;tr|K7EIT4|K7EIT4_HUMAN;tr|I3L0W5|I3L0W5_HUMAN","sp|P62258|1433E_HUMAN",1880,"P62258","1433E_HUMAN","14-3-3 protein epsilon","4-3-3E","YWHAE"]
["15.7526","15.2579","16.0387","14.9724",{"$nulls":3},"actin filament network formation;actin filament polymerization;collateral sprouting in absence of injury;digestive tract development;embryonic axis specification;floor plate development;liver development;neural tube closure;notochord development;positive regulation of dendrite development;positive regulation of ruffle assembly;somite specification","actin monomer binding","actin filament;axon;axonal growth cone;cell cortex;dendrite;dendritic growth cone;neuronal cell body;perinuclear region of cytoplasm;plasma membrane;ruffle",{"$nulls":3},11,11,11,"12.8","12.8","12.8","135.62",0,"21.559",134910000,36,"0.000174184",1,"-0.000333309","-0.000567091","sp|O75128|COBL_HUMAN;tr|J3KR05|J3KR05_HUMAN;tr|H7C1N2|H7C1N2_HUMAN;tr|H7C2C4|H7C2C4_HUMAN;tr|A0A0J9YWK3|A0A0J9YWK3_HUMAN;tr|C9J9X1|C9J9X1_HUMAN","sp|O75128|COBL_HUMAN;tr|J3KR05|J3KR05_HUMAN;tr|H7C1N2|H7C1N2_HUMAN",524,"O75128","COBL_HUMAN","Protein cordon-bleu",null,"COBL"]
["19.3902","20.078","19.5104","19.9603",{"$nulls":3},"regulation of cell adhesion;regulation of signaling","metal ion binding","integral component of membrane",{"$nulls":3},27,27,27,"28.5","28.5","28.5","145.42",0,"114.33",695470000,84,"0.000926069",1,"-0.00123787","-0.0030124","tr|E9PMS6|E9PMS6_HUMAN;tr|A0A0A0MTE2|A0A0A0MTE2_HUMAN;tr|E9PMT2|E9PMT2_HUMAN;tr|F8WD26|F8WD26_HUMAN;tr|J3KP06|J3KP06_HUMAN;sp|Q8WWI1|LMO7_HUMAN;tr|E9PMP7|E9PMP7_HUMAN;tr|H0Y424|H0Y424_HUMAN;tr|H0YDG6|H0YDG6_HUMAN;tr|E9PJ10|E9PJ10_HUMAN;tr|E9PK58|E9PK58_HUMAN;tr|E9PLU6|E9PLU6_HUMAN;tr|H0YE95|H0YE95_HUMAN;tr|H0YDQ3|H0YDQ3_HUMAN;tr|E9PRE3|E9PRE3_HUMAN;tr|E9PRJ0|E9PRJ0_HUMAN","tr|E9PMS6|E9PMS6_HUMAN;tr|A0A0A0MTE2|A0A0A0MTE2_HUMAN;tr|E9PMT2|E9PMT2_HUMAN;tr|F8WD26|F8WD26_HUMAN;tr|J3KP06|J3KP06_HUMAN;sp|Q8WWI1|LMO7_HUMAN;tr|E9PMP7|E9PMP7_HUMAN;tr|H0Y424|H0Y424_HUMAN",5219,"E9PMS6","E9PMS6_HUMAN",null,null,"LMO7"]
["18.0297","18.4873","18.8663","17.6566",{"$nulls":3},"tRNA modification;tRNA N2-guanine methylation","metal ion binding;RNA binding;tRNA (guanine-N2-)-methyltransferase activity;tRNA binding","mitochondrion;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"11.1","11.1","11.1","72.233",0,"20.322",100740000,18,"0.00141025",1,"-0.00296497","-0.00458483","sp|Q9NXH9|TRM1_HUMAN;tr|K7EQQ8|K7EQQ8_HUMAN;tr|K7EMZ2|K7EMZ2_HUMAN;tr|K7EQY6|K7EQY6_HUMAN;tr|K7ENI9|K7ENI9_HUMAN;tr|K7ERR5|K7ERR5_HUMAN;tr|K7EQU7|K7EQU7_HUMAN","sp|Q9NXH9|TRM1_HUMAN;tr|K7EQQ8|K7EQQ8_HUMAN",4548,"Q9NXH9","TRM1_HUMAN","tRNA (guanine(26)-N(2))-dimethyltransferase",null,"TRMT1"]
["21.4365","21.7666","21.7658","21.4465",{"$nulls":3},"vesicle-mediated transport","cadherin binding","cytoplasm;cytosol;endosome;endosome membrane;Golgi apparatus;lipid droplet;membrane;transport vesicle",{"$nulls":3},12,12,12,"45.9","45.9","45.9","47.074",0,"107.84",760560000,60,"0.00620973",1,"-0.00461006","-0.0200792","sp|O60664|PLIN3_HUMAN;tr|K7ERZ3|K7ERZ3_HUMAN;tr|K7EL96|K7EL96_HUMAN;tr|K7ER39|K7ER39_HUMAN;tr|K7EJD0|K7EJD0_HUMAN","sp|O60664|PLIN3_HUMAN;tr|K7ERZ3|K7ERZ3_HUMAN;tr|K7EL96|K7EL96_HUMAN",490,"O60664","PLIN3_HUMAN","Perilipin-3",null,"PLIN3"]
["16.175","16.179","16.5909","15.7737",{"$nulls":3},"centriole replication;cerebral cortex development;mitotic spindle organization;neurogenesis;RNA splicing","RNA binding","catalytic step 2 spliceosome;centriole;centrosome;nucleus;precatalytic spliceosome;spindle pole;U5 snRNP",{"$nulls":3},3,3,3,"2.9","2.9","2.9","165.95",0,"14.711",48622000,14,"0.00400575",1,"-0.00530577","-0.0129847","sp|O43379|WDR62_HUMAN;tr|H7C3R4|H7C3R4_HUMAN","sp|O43379|WDR62_HUMAN",393,"O43379","WDR62_HUMAN","WD repeat-containing protein 62",null,"WDR62"]
["23.7306","23.4467","24.0439","23.1461",{"$nulls":3},"positive regulation of gene expression;transcription from RNA polymerase II promoter","DNA binding transcription factor activity;RNA binding;single-stranded DNA binding","nucleus",{"$nulls":3},24,24,13,"52.3","52.3","27.8","67.56",0,"192.99",3417000000,239,"0.00419774",1,"-0.00640488","-0.0136041","sp|Q96AE4|FUBP1_HUMAN;tr|E9PEB5|E9PEB5_HUMAN","sp|Q96AE4|FUBP1_HUMAN;tr|E9PEB5|E9PEB5_HUMAN",3599,"Q96AE4","FUBP1_HUMAN","Far upstream element-binding protein 1","BP;USE-binding protein 1","FUBP1"]
["22.2529","22.0628","22.5187","21.8105",{"$nulls":3},"B cell proliferation;CTP biosynthetic process;'de novo' CTP biosynthetic process;glutamine metabolic process;nucleobase-containing compound metabolic process;nucleobase-containing small molecule interconversion;response to drug;T cell proliferation","ATP binding;CTP synthase activity;identical protein binding","cytosol;membrane","Metabolic pathways;Pyrimidine metabolism",null,null,18,18,16,"40.4","40.4",36,"66.69",0,"95.44",1316800000,73,"0.00569772",1,"-0.00675869","-0.0184342","sp|P17812|PYRG1_HUMAN","sp|P17812|PYRG1_HUMAN",1104,"P17812","PYRG1_HUMAN","CTP synthase 1 {ECO:0000305}",null,"CTPS1"]
["15.6663",1,"15.6803",1,{"$nulls":3},"cell division;centrosome cycle;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;regulation of G2/M transition of mitotic cell cycle;spindle assembly",null,"centrosome;cytosol;HAUS complex;microtubule;spindle",{"$nulls":3},2,2,2,"3.8","3.8","3.8","71.682","0.00046468","4.8299",8822800,4,"0.00020637",1,"-0.00697088","-0.000671854","sp|O94927|HAUS5_HUMAN","sp|O94927|HAUS5_HUMAN",676,"O94927","HAUS5_HUMAN","HAUS augmin-like complex subunit 5",null,"HAUS5"]
["22.6729","23.5274","23.078","23.1374",{"$nulls":3},"anaerobic respiration;mitochondrial electron transport, succinate to ubiquinone;nervous system development;oxidation-reduction process;respiratory electron transport chain;succinate metabolic process;tricarboxylic acid cycle","electron transfer activity;flavin adenine dinucleotide binding;succinate dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);mitochondrion;myelin sheath;nucleolus","Alzheimer disease;Carbon metabolism;Citrate cycle (TCA cycle);Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,24,24,24,"49.7","49.7","49.7","72.691",0,"249.07",2290100000,117,"0.00545246",1,"-0.00755787","-0.0176455","sp|P31040|SDHA_HUMAN;tr|D6RFM5|D6RFM5_HUMAN;tr|A0A087X1I3|A0A087X1I3_HUMAN;tr|H0Y8X1|H0Y8X1_HUMAN","sp|P31040|SDHA_HUMAN;tr|D6RFM5|D6RFM5_HUMAN;tr|A0A087X1I3|A0A087X1I3_HUMAN",1323,"P31040","SDHA_HUMAN","Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",null,"SDHA"]
["20.0507","20.5391","20.2747","20.3331",{"$nulls":3},"cellular response to lipopolysaccharide;endodermal cell fate commitment;histone H2B ubiquitination;histone monoubiquitination;mRNA polyadenylation;negative regulation of myeloid cell differentiation;negative regulation of transcription from RNA polymerase II promoter;nucleosome positioning;positive regulation of cell cycle G1/S phase transition;positive regulation of histone methylation;positive regulation of mRNA 3'-end processing;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein localization to nucleus;protein ubiquitination;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;Wnt signaling pathway","chromatin binding;RNA polymerase II core binding","Cdc73/Paf1 complex;cell junction;cytoplasm;membrane;nucleoplasm",{"$nulls":3},14,14,14,"34.3","34.3","34.3","59.975",0,"43.795",746930000,90,"0.0113859",1,"-0.00900173","-0.0366068","sp|Q8N7H5|PAF1_HUMAN;tr|B4DGJ5|B4DGJ5_HUMAN;tr|M0QYC7|M0QYC7_HUMAN","sp|Q8N7H5|PAF1_HUMAN;tr|B4DGJ5|B4DGJ5_HUMAN",3260,"Q8N7H5","PAF1_HUMAN","RNA polymerase II-associated factor 1 homolog","PAF1","PAF1"]
["24.0893","23.8804","24.3231","23.6657",{"$nulls":3},"negative regulation of canonical Wnt signaling pathway;Ras protein signal transduction","ATP binding;ATP-dependent DNA helicase activity;ATP-dependent RNA helicase activity;DNA binding;endonuclease activity;mRNA binding;RNA binding","cytoplasmic stress granule;cytosol;focal adhesion;intracellular ribonucleoprotein complex;nucleus;plasma membrane",{"$nulls":3},14,14,13,"39.7","39.7",38,"52.164",0,"245.63",3591200000,160,"0.00854998",1,"-0.00951099","-0.0275747","sp|Q13283|G3BP1_HUMAN;tr|E5RIZ6|E5RIZ6_HUMAN;tr|E5RI46|E5RI46_HUMAN;tr|E5RIF8|E5RIF8_HUMAN;tr|E5RH42|E5RH42_HUMAN;tr|E5RJU8|E5RJU8_HUMAN;tr|E5RH00|E5RH00_HUMAN","sp|Q13283|G3BP1_HUMAN",2232,"Q13283","G3BP1_HUMAN","Ras GTPase-activating protein-binding protein 1","3BP-1","G3BP1"]
["23.3692","23.493","23.7249","23.1573",{"$nulls":3},"translational initiation","translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex;eukaryotic translation initiation factor 3 complex, eIF3m;extracellular exosome","RNA transport",null,null,16,16,16,"65.8","65.8","65.8","36.501",0,"127.35",1895600000,99,"0.0107199",1,"-0.0100193","-0.0344907","sp|Q13347|EIF3I_HUMAN;tr|Q5TFK1|Q5TFK1_HUMAN","sp|Q13347|EIF3I_HUMAN",2238,"Q13347","EIF3I_HUMAN","Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008}","IF3i {ECO:0000255|HAMAP-Rule:MF_03008}","EIF3I"]
["21.2841","20.7681","21.4345","20.6399",{"$nulls":3},"mRNA splicing, via spliceosome;negative regulation of phosphatase activity;spliceosomal tri-snRNP complex assembly","ribonucleoprotein complex binding","cytoplasm;cytosol;fibrillar center;nuclear speck;nucleoplasm;nucleus;U5 snRNP",{"$nulls":3},6,6,6,"26.4","26.4","26.4","37.646",0,"84.031",514290000,47,"0.00726706",1,"-0.0111189","-0.0234704","sp|O95400|CD2B2_HUMAN","sp|O95400|CD2B2_HUMAN",731,"O95400","CD2B2_HUMAN","CD2 antigen cytoplasmic tail-binding protein 2","D2 cytoplasmic domain-binding protein 2;D2 tail-binding protein 2","CD2BP2"]
["19.7901","20.078","19.6367","20.2541",{"$nulls":3},"epoxygenase P450 pathway","arachidonic acid epoxygenase activity;aromatase activity;heme binding;iron ion binding;retinoic acid 4-hydroxylase activity;steroid hydroxylase activity","endoplasmic reticulum;endoplasmic reticulum membrane;organelle membrane","Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Retinol metabolism",null,null,8,8,8,"23.2","23.2","23.2","55.816",0,"35.245",401110000,48,"0.0103608",1,"-0.0113573","-0.0333483","sp|Q96SQ9|CP2S1_HUMAN;tr|M0R152|M0R152_HUMAN;tr|M0R057|M0R057_HUMAN;tr|M0R2G8|M0R2G8_HUMAN","sp|Q96SQ9|CP2S1_HUMAN",3822,"Q96SQ9","CP2S1_HUMAN","Cytochrome P450 2S1",null,"CYP2S1"]
["21.1688","21.1152","21.516","20.7927",{"$nulls":3},"actomyosin structure organization;epithelial cell differentiation;negative regulation of ATPase activity","actin binding;cadherin binding involved in cell-cell adhesion;calmodulin binding;microtubule binding","actin cytoskeleton;cell-cell adherens junction;cytosol;dendritic spine;focal adhesion;neuronal cell body;postsynaptic density",{"$nulls":3},8,7,7,"39.8","36.5","36.5","36.413",0,"97.542",340570000,30,"0.0106132",1,"-0.0123835","-0.0341515","sp|Q15417|CNN3_HUMAN;tr|E9PDU6|E9PDU6_HUMAN","sp|Q15417|CNN3_HUMAN;tr|E9PDU6|E9PDU6_HUMAN",2487,"Q15417","CNN3_HUMAN","Calponin-3",null,"CNN3"]
["15.893",1,"15.9178",1,{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;zinc ion binding","nucleus",{"$nulls":3},8,8,8,"25.6","25.6","25.6","38.971",0,"13.717",143790000,14,"0.000362103",1,"-0.0124226","-0.00117864","sp|O75764|TCEA3_HUMAN;tr|S4R3M9|S4R3M9_HUMAN;tr|S4R419|S4R419_HUMAN","sp|O75764|TCEA3_HUMAN",608,"O75764","TCEA3_HUMAN","Transcription elongation factor A protein 3",null,"TCEA3"]
["15.0581","15.6559","15.6661","15.0756",{"$nulls":9},3,3,3,"2.9","2.9","2.9","189.97",0,"8.6822",49628000,13,"0.0102005",1,"-0.0137973","-0.0328382","sp|Q2KHR3|QSER1_HUMAN","sp|Q2KHR3|QSER1_HUMAN",2591,"Q2KHR3","QSER1_HUMAN","Glutamine and serine-rich protein 1",null,"QSER1"]
["22.7226","23.2829","22.9608","23.0734",{"$nulls":3},"angiogenesis;cellular response to leukemia inhibitory factor;establishment of Golgi localization;Golgi reassembly;intrinsic apoptotic signaling pathway in response to hydrogen peroxide;negative regulation of apoptotic process;negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;negative regulation of cell migration involved in sprouting angiogenesis;negative regulation of gene expression;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of gene expression;positive regulation of intracellular protein transport;positive regulation of MAP kinase activity;positive regulation of Notch signaling pathway;positive regulation of peptidyl-serine phosphorylation;positive regulation of protein serine/threonine kinase activity;positive regulation of stress-activated MAPK cascade;protein stabilization;response to hydrogen peroxide;wound healing, spreading of cells","protein homodimerization activity;protein kinase binding;protein N-terminus binding","cytoplasm;cytosol;extracellular exosome;Golgi apparatus;Golgi membrane;plasma membrane",{"$nulls":3},11,11,11,"60.8","60.8","60.8","24.701",0,"105.29",967800000,68,"0.0157019",1,"-0.0143595","-0.0502493","sp|Q9BUL8|PDC10_HUMAN;tr|C9J5C3|C9J5C3_HUMAN;tr|C9J6F3|C9J6F3_HUMAN;tr|C9J363|C9J363_HUMAN;tr|C9JSA3|C9JSA3_HUMAN;tr|C9JND6|C9JND6_HUMAN;tr|H7C5M9|H7C5M9_HUMAN;tr|C9J932|C9J932_HUMAN;tr|F8WDF3|F8WDF3_HUMAN","sp|Q9BUL8|PDC10_HUMAN;tr|C9J5C3|C9J5C3_HUMAN;tr|C9J6F3|C9J6F3_HUMAN;tr|C9J363|C9J363_HUMAN;tr|C9JSA3|C9JSA3_HUMAN;tr|C9JND6|C9JND6_HUMAN;tr|H7C5M9|H7C5M9_HUMAN",3989,"Q9BUL8","PDC10_HUMAN","Programmed cell death protein 10",null,"PDCD10"]
["19.1532","18.3385","19.5551","17.9667",{"$nulls":3},"signal transduction",null,"membrane;plasma membrane",{"$nulls":3},11,11,11,"24.3","24.3","24.3","68.249",0,"24.105",145820000,24,"0.00520325",1,"-0.0150347","-0.0168437","sp|Q9H9A6|LRC40_HUMAN","sp|Q9H9A6|LRC40_HUMAN",4272,"Q9H9A6","LRC40_HUMAN","Leucine-rich repeat-containing protein 40",null,"LRRC40"]
["20.8207","21.2262","20.6495","21.429",{"$nulls":9},3,3,3,"15.2","15.2","15.2","21.848",0,"10.307",296630000,13,"0.0111577",1,"-0.0157633","-0.0358822","sp|Q5VYY1|ANR22_HUMAN","sp|Q5VYY1|ANR22_HUMAN",2770,"Q5VYY1","ANR22_HUMAN","Ankyrin repeat domain-containing protein 22",null,"ANKRD22"]
["27.2857","26.8971","27.3377","26.8788",{"$nulls":3},"angiogenesis;ATP biosynthetic process;cristae formation;generation of precursor metabolites and energy;lipid metabolic process;mitochondrial ATP synthesis coupled proton transport;mitochondrion organization;negative regulation of cell adhesion involved in substrate-bound cell migration;osteoblast differentiation;positive regulation of blood vessel endothelial cell migration;proton transport;regulation of intracellular pH","angiostatin binding;ATP binding;MHC class I protein binding;proton-transporting ATP synthase activity, rotational mechanism;proton-transporting ATPase activity, rotational mechanism;transmembrane transporter activity;transporter activity","cell surface;extracellular exosome;extracellular matrix;membrane;mitochondrial matrix;mitochondrial membrane;mitochondrial nucleoid;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase, catalytic core;mitochondrion;myelin sheath;nucleus;plasma membrane;proton-transporting ATP synthase complex","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,27,27,17,"71.8","71.8",48,"56.559",0,"323.31",35049000000,821,"0.0175401",1,"-0.0168447","-0.0560225","sp|P06576|ATPB_HUMAN;tr|H0YH81|H0YH81_HUMAN;tr|F8W079|F8W079_HUMAN;tr|H0YI37|H0YI37_HUMAN","sp|P06576|ATPB_HUMAN;tr|H0YH81|H0YH81_HUMAN;tr|F8W079|F8W079_HUMAN",875,"P06576","ATPB_HUMAN","ATP synthase subunit beta, mitochondrial",null,"ATP5B"]
["23.517","23.7196","23.5567","23.7143",{"$nulls":3},"cellular response to oxidative stress;cholesterol biosynthetic process;erythrocyte maturation;glucose 6-phosphate metabolic process;glucose metabolic process;glutathione metabolic process;lipid metabolic process;NADP metabolic process;NADPH regeneration;negative regulation of cell growth involved in cardiac muscle cell development;negative regulation of protein glutathionylation;negative regulation of reactive oxygen species metabolic process;oxidation-reduction process;pentose biosynthetic process;pentose-phosphate shunt;pentose-phosphate shunt, oxidative branch;positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;regulation of neuron apoptotic process;response to ethanol;response to food;response to iron(III) ion;response to organic cyclic compound;ribose phosphate biosynthetic process;substantia nigra development","glucose binding;glucose-6-phosphate dehydrogenase activity;identical protein binding;NADP binding;protein homodimerization activity","cytoplasm;cytoplasmic side of plasma membrane;cytosol;extracellular exosome;membrane;nucleus","Carbon metabolism;Central carbon metabolism in cancer;Glutathione metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,28,28,28,"58.1","58.1","58.1","59.256",0,"123.01",3795100000,150,"0.0430063",1,"-0.0171881","-0.133929","sp|P11413|G6PD_HUMAN;tr|E7EUI8|E7EUI8_HUMAN;tr|E7EM57|E7EM57_HUMAN;tr|E9PD92|E9PD92_HUMAN","sp|P11413|G6PD_HUMAN;tr|E7EUI8|E7EUI8_HUMAN;tr|E7EM57|E7EM57_HUMAN;tr|E9PD92|E9PD92_HUMAN",997,"P11413","G6PD_HUMAN","Glucose-6-phosphate 1-dehydrogenase","6PD","G6PD"]
["24.8574","21.6373","25.1743","21.3567",{"$nulls":3},"cholesterol biosynthetic process;isoprenoid biosynthetic process;ketone body biosynthetic process;regulation of lipid metabolic process","hydroxymethylglutaryl-CoA synthase activity","mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Butanoate metabolism;Metabolic pathways;PPAR signaling pathway;Synthesis and degradation of ketone bodies;Terpenoid backbone biosynthesis;Valine, leucine and isoleucine degradation",null,null,19,19,18,"44.9","44.9","42.7","56.635",0,"323.31",2692200000,100,"0.00223602",1,"-0.018136","-0.00726264","sp|P54868|HMCS2_HUMAN","sp|P54868|HMCS2_HUMAN",1745,"P54868","HMCS2_HUMAN","Hydroxymethylglutaryl-CoA synthase, mitochondrial","MG-CoA synthase","HMGCS2"]
["15.4099",1,"15.4478",1,{"$nulls":3},"cellular respiration;mitochondrial RNA metabolic process;regulation of mitochondrial mRNA stability","protein kinase activity;RNA binding","mitochondrion",{"$nulls":3},2,2,2,3,3,3,"97.41","0.0056079","2.6664",16992000,1,"0.00057134",1,"-0.0189695","-0.00185926","sp|Q53R41|FAKD1_HUMAN","sp|Q53R41|FAKD1_HUMAN",2663,"Q53R41","FAKD1_HUMAN","FAST kinase domain-containing protein 1, mitochondrial",null,"FASTKD1"]
["17.6258","16.2605","17.761","16.1643",{"$nulls":3},"intracellular signal transduction;peptidyl-serine phosphorylation","ATP binding;protein serine/threonine kinase activity","cytoplasm;intracellular;membrane",{"$nulls":3},4,4,4,"12.4","12.4","12.4","44.765","0.00026378","7.4965",34923000,7,"0.0057299",1,"-0.0194721","-0.0185376","sp|Q6A1A2|PDPK2_HUMAN;tr|E9PER6|E9PER6_HUMAN;sp|O15530|PDPK1_HUMAN;tr|H3BQ10|H3BQ10_HUMAN;tr|H3BPW1|H3BPW1_HUMAN","sp|Q6A1A2|PDPK2_HUMAN;tr|E9PER6|E9PER6_HUMAN;sp|O15530|PDPK1_HUMAN;tr|H3BQ10|H3BQ10_HUMAN",369,"Q6A1A2","PDPK2_HUMAN","Putative 3-phosphoinositide-dependent protein kinase 2",null,"PDPK2P"]
["19.1629","20.2642","19.5079","19.9604",{"$nulls":3},"cell division;DNA-dependent DNA replication;sister chromatid cohesion","chromatin binding","cytosol;nuclear chromatin;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},10,10,10,"23.8","23.8","23.8","72.979",0,"72.973",297040000,31,"0.0107578",1,"-0.0206041","-0.0346111","sp|Q9BTE3|MCMBP_HUMAN","sp|Q9BTE3|MCMBP_HUMAN",3966,"Q9BTE3","MCMBP_HUMAN","Mini-chromosome maintenance complex-binding protein","CM-binding protein;CM-BP","MCMBP"]
["24.4264","25.2326","24.7867","24.9146",{"$nulls":3},"ion transport","actin filament binding;cadherin binding;ion transmembrane transporter activity;metal ion binding;SH3/SH2 adaptor activity","cortical actin cytoskeleton;cytoplasm;extracellular exosome;focal adhesion",{"$nulls":3},13,13,13,"55.2","55.2","55.2","29.717",0,"90.084",3123600000,89,"0.016157",1,"-0.0210924","-0.0516808","sp|Q14847|LASP1_HUMAN;tr|C9J9W2|C9J9W2_HUMAN;tr|F6S2S5|F6S2S5_HUMAN;tr|J3KSN1|J3KSN1_HUMAN;tr|K7ESD6|K7ESD6_HUMAN","sp|Q14847|LASP1_HUMAN;tr|C9J9W2|C9J9W2_HUMAN",2400,"Q14847","LASP1_HUMAN","LIM and SH3 domain protein 1","ASP-1","LASP1"]
["22.3973","22.9504","22.6996","22.6918",{"$nulls":3},"axon guidance;cellular response to interferon-gamma;centrosome localization;cytoplasm organization;cytoskeleton-dependent intracellular transport;hippocampus development;microtubule-based movement;plus-end-directed vesicle transport along microtubule;positive regulation of insulin secretion involved in cellular response to glucose stimulus;positive regulation of intracellular protein transport;positive regulation of potassium ion transport;positive regulation of protein localization to plasma membrane;positive regulation of synaptic transmission, GABAergic;positive regulation of vesicle fusion;positive regulation of voltage-gated sodium channel activity;regulation of membrane potential;stress granule disassembly;vesicle transport along microtubule","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;cadherin binding;identical protein binding;JUN kinase binding;microtubule binding;microtubule lateral binding;microtubule motor activity","axonal growth cone;ciliary rootlet;cytosol;kinesin complex;membrane;microtubule;microtubule organizing center;perinuclear region of cytoplasm;phagocytic vesicle;vesicle","Dopaminergic synapse;Endocytosis",null,null,39,39,39,"49.4","49.4","49.4","109.68",0,"323.31",3469900000,209,"0.0249658",1,"-0.021884","-0.0791282","sp|P33176|KINH_HUMAN;sp|O60282|KIF5C_HUMAN;tr|A0A0G2JMZ6|A0A0G2JMZ6_HUMAN;sp|Q12840|KIF5A_HUMAN;tr|J3KNA1|J3KNA1_HUMAN","sp|P33176|KINH_HUMAN",1355,"P33176","KINH_HUMAN","Kinesin-1 heavy chain",null,"KIF5B"]
["19.9628","20.7173","20.1603","20.5646",{"$nulls":3},"DNA replication;nucleosome assembly;nucleosome disassembly","chromatin binding;DNA replication origin binding;histone binding;RNA binding","chromosome;cytosol;nucleolus;nucleus;protein complex",{"$nulls":3},6,6,6,"22.4","22.4","22.4","49.419",0,"58.248",453480000,34,"0.016338",1,"-0.0223627","-0.0522496","sp|Q9BQ67|GRWD1_HUMAN;tr|M0QX71|M0QX71_HUMAN","sp|Q9BQ67|GRWD1_HUMAN;tr|M0QX71|M0QX71_HUMAN",3911,"Q9BQ67","GRWD1_HUMAN","Glutamate-rich WD repeat-containing protein 1",null,"GRWD1"]
["17.8323",1,"17.8787",1,{"$nulls":5},"cytoplasm;integral component of peroxisomal membrane;membrane;peroxisomal membrane;protein complex","Peroxisome",null,null,3,3,3,19,19,19,"22.252","0.00024085","5.5736",36914000,4,"0.000599112",1,"-0.0232363","-0.00194957","sp|Q9NR77|PXMP2_HUMAN;tr|F5H4N4|F5H4N4_HUMAN;tr|F5GXM0|F5GXM0_HUMAN;tr|F5GZF7|F5GZF7_HUMAN;tr|A0A087X249|A0A087X249_HUMAN","sp|Q9NR77|PXMP2_HUMAN;tr|F5H4N4|F5H4N4_HUMAN;tr|F5GXM0|F5GXM0_HUMAN",4412,"Q9NR77","PXMP2_HUMAN","Peroxisomal membrane protein 2",null,"PXMP2"]
["23.0312","24.2351","23.3187","23.9946",{"$nulls":3},"tricarboxylic acid cycle","cofactor binding;nucleotide binding;RNA binding;succinate-CoA ligase (ADP-forming) activity;succinate-CoA ligase (GDP-forming) activity","cytosol;extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion;plasma membrane","Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways;Propanoate metabolism",null,null,8,8,8,"30.1","30.1","30.1","36.249",0,"122.74",1683500000,85,"0.0105981",1,"-0.0235434","-0.0341034","sp|P53597|SUCA_HUMAN;tr|H7C233|H7C233_HUMAN","sp|P53597|SUCA_HUMAN",1714,"P53597","SUCA_HUMAN","Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03222}",null,"SUCLG1"]
["23.3886","23.1712","23.6385","22.9695",{"$nulls":3},"actin cytoskeleton organization;activation of GTPase activity;establishment of protein localization;negative regulation of epithelial cell migration;negative regulation of focal adhesion assembly;negative regulation of protein kinase activity by regulation of protein phosphorylation;negative regulation of protein phosphorylation;negative regulation of substrate adhesion-dependent cell spreading;neural crest cell migration;phagocytosis;positive regulation of lamellipodium morphogenesis;regulation of epithelial cell migration;regulation of fibroblast migration;regulation of focal adhesion assembly;regulation of protein phosphorylation;regulation of ruffle assembly;regulation of substrate adhesion-dependent cell spreading;signal transduction","actin filament binding;Rac GTPase binding","actin cytoskeleton;cytoplasm;flotillin complex;focal adhesion;lamellipodium;lateral plasma membrane",{"$nulls":3},12,12,12,"32.5","32.5","32.5","53.248",0,"218.3",1598000000,52,"0.0215205",1,"-0.0240774","-0.0684504","sp|Q9ULV4|COR1C_HUMAN;tr|B4E3S0|B4E3S0_HUMAN;tr|H0YHL7|H0YHL7_HUMAN;tr|F8W1H8|F8W1H8_HUMAN;tr|F8VUX3|F8VUX3_HUMAN;tr|F8VSA4|F8VSA4_HUMAN;tr|F8VRE9|F8VRE9_HUMAN;tr|F8VTT6|F8VTT6_HUMAN;tr|F8VVB7|F8VVB7_HUMAN;tr|F8VV53|F8VV53_HUMAN","sp|Q9ULV4|COR1C_HUMAN;tr|B4E3S0|B4E3S0_HUMAN",4826,"Q9ULV4","COR1C_HUMAN","Coronin-1C",null,"CORO1C"]
["22.0298","21.0471","22.2673","20.8584",{"$nulls":3},"cellular response to glucagon stimulus;G-protein coupled receptor signaling pathway;protein folding","calcium channel regulator activity;GTPase activity;GTPase binding;protein complex binding;signal transducer activity","cell body;cytosol;extracellular exosome;extracellular space;focal adhesion;lysosomal membrane;membrane;myelin sheath;perinuclear region of cytoplasm;plasma membrane;protein complex;vesicle","Alcoholism;Apelin signaling pathway;Chemokine signaling pathway;Cholinergic synapse;Circadian entrainment;Dopaminergic synapse;GABAergic synapse;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Morphine addiction;Pathways in cancer;PI3K-Akt signaling pathway;Ras signaling pathway;Relaxin signaling pathway;Retrograde endocannabinoid signaling;Serotonergic synapse",null,null,7,3,3,"28.2","13.2","13.2","37.331",0,"35.875",395240000,24,"0.00882695",1,"-0.0244436","-0.0284592","sp|P62879|GBB2_HUMAN;tr|C9JIS1|C9JIS1_HUMAN;tr|C9JXA5|C9JXA5_HUMAN;tr|C9JZN1|C9JZN1_HUMAN;tr|E7EP32|E7EP32_HUMAN;sp|Q9HAV0|GBB4_HUMAN;tr|C9JD14|C9JD14_HUMAN","sp|P62879|GBB2_HUMAN;tr|C9JIS1|C9JIS1_HUMAN;tr|C9JXA5|C9JXA5_HUMAN;tr|C9JZN1|C9JZN1_HUMAN;tr|E7EP32|E7EP32_HUMAN",1921,"P62879","GBB2_HUMAN","Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2",null,"GNB2"]
["19.7337","21.6504","19.635","21.7997",{"$nulls":3},"aging;axon guidance;cellular response to fatty acid;cellular response to hepatocyte growth factor stimulus;cellular response to insulin-like growth factor stimulus;cellular response to leukemia inhibitory factor;cellular response to nerve growth factor stimulus;cellular response to platelet-derived growth factor stimulus;cellular response to zinc ion;chemotaxis to arachidonic acid;circadian rhythm;lactation;lung saccule development;memory;negative regulation of neuron death;negative regulation of transcription by competitive promoter binding;pituitary gland development;positive regulation of apoptotic process;positive regulation of cardiac muscle tissue development;positive regulation of fat cell differentiation;positive regulation of hormone secretion;positive regulation of lipid biosynthetic process;positive regulation of long-term synaptic potentiation;positive regulation of multicellular organism growth;positive regulation of osteoclast differentiation;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of transforming growth factor beta3 production;protein kinase B signaling;protein phosphorylation;protein stabilization;regulation of cell size;regulation of circadian rhythm;regulation of fibroblast proliferation;regulation of glial cell proliferation;response to activity;response to drug;response to glucagon;response to hypoxia;response to L-glutamate;response to nicotine;response to organic substance;secretory granule organization;signal transduction;transforming growth factor beta receptor signaling pathway;Type I pneumocyte differentiation;viral process;visual learning","arrestin family protein binding;cAMP response element binding;DNA binding transcription factor activity;enzyme binding;histone acetyltransferase binding;Hsp70 protein binding;identical protein binding;RNA polymerase II activating transcription factor binding;RNA polymerase II distal enhancer sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;RNA polymerase II transcription coactivator binding;transcription cofactor activity;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription factor binding","ATF4-CREB1 transcription factor complex;axon;mitochondrial matrix;nuclear euchromatin;nucleoplasm;nucleus","Adrenergic signaling in cardiomyocytes;Alcoholism;Aldosterone synthesis and secretion;Amphetamine addiction;AMPK signaling pathway;Antigen processing and presentation;cAMP signaling pathway;cGMP-PKG signaling pathway;Cholinergic synapse;Circadian entrainment;Circadian rhythm;Cocaine addiction;Cortisol synthesis and secretion;Cushing syndrome;Dopaminergic synapse;Estrogen signaling pathway;Glucagon signaling pathway;Hepatitis B;Human cytomegalovirus infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Huntington disease;Insulin resistance;Insulin secretion;Kaposi sarcoma-associated herpesvirus infection;Longevity regulating pathway;Melanogenesis;Osteoclast differentiation;Parathyroid hormone synthesis, secretion and action;PI3K-Akt signaling pathway;Prostate cancer;Relaxin signaling pathway;Renin secretion;Thermogenesis;Thyroid hormone synthesis;TNF signaling pathway;Tuberculosis;Vasopressin-regulated water reabsorption;Viral carcinogenesis",null,null,3,3,2,"15.2","15.2","12.6","36.688","0.00025786","7.0276",192290000,17,"0.00541022",1,"-0.0253124","-0.0175096","sp|P16220|CREB1_HUMAN;tr|C9JBT4|C9JBT4_HUMAN;tr|C9J896|C9J896_HUMAN;tr|E9PAR2|E9PAR2_HUMAN;tr|C9J4L5|C9J4L5_HUMAN;tr|H7C1R5|H7C1R5_HUMAN;tr|H7C3I0|H7C3I0_HUMAN;tr|E7EWP8|E7EWP8_HUMAN;tr|G5E998|G5E998_HUMAN","sp|P16220|CREB1_HUMAN;tr|C9JBT4|C9JBT4_HUMAN;tr|C9J896|C9J896_HUMAN",1076,"P16220","CREB1_HUMAN","Cyclic AMP-responsive element-binding protein 1","AMP-responsive element-binding protein 1;REB-1","CREB1"]
["21.7856","22.1364","22.105","21.868",{"$nulls":3},"cell division;kinetochore organization;meiotic chromosome condensation;meiotic chromosome segregation;mitotic chromosome condensation","ATP binding;protein heterodimerization activity","condensed chromosome;condensin complex;cytoplasm;cytosol;extracellular exosome;nuclear chromosome;nucleolus;nucleoplasm;nucleus",{"$nulls":3},54,54,54,49,49,49,"135.65",0,"272.91",6955100000,494,"0.0385773",1,"-0.0255337","-0.12064","sp|O95347|SMC2_HUMAN;tr|A0A0C4DGE5|A0A0C4DGE5_HUMAN;tr|Q5T821|Q5T821_HUMAN","sp|O95347|SMC2_HUMAN",718,"O95347","SMC2_HUMAN","Structural maintenance of chromosomes protein 2","MC protein 2;MC-2","SMC2"]
[1,"15.4076",1,"15.4594",{"$nulls":3},"motor neuron migration",null,"membrane",{"$nulls":3},6,6,6,"5.8","5.8","5.8","170.67",0,"14.276",50436000,10,"0.000779992",1,"-0.0258994","-0.00253765","sp|Q5SYE7|NHSL1_HUMAN;tr|H0YDF6|H0YDF6_HUMAN;tr|E9PAK2|E9PAK2_HUMAN","sp|Q5SYE7|NHSL1_HUMAN",2718,"Q5SYE7","NHSL1_HUMAN","NHS-like protein 1",null,"NHSL1"]
["21.7457","22.2333","21.8947","22.1387",{"$nulls":3},"ER to Golgi vesicle-mediated transport;establishment of Golgi localization;intracellular protein transport;organelle transport along microtubule;retrograde vesicle-mediated transport, Golgi to ER","structural molecule activity","COPI vesicle coat;cytosol;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;transport vesicle",{"$nulls":3},22,22,20,"32.7","32.7","30.4","97.717",0,"230.77",1808600000,107,"0.0317216",1,"-0.0272236","-0.0998623","sp|Q9Y678|COPG1_HUMAN;tr|H0Y8X7|H0Y8X7_HUMAN;tr|D6RG17|D6RG17_HUMAN","sp|Q9Y678|COPG1_HUMAN",5079,"Q9Y678","COPG1_HUMAN","Coatomer subunit gamma-1",null,"COPG1"]
["24.8886","24.8542","25.1565","24.6421",{"$nulls":3},"cell redox homeostasis","isomerase activity","cell",{"$nulls":3},18,18,18,"68.6","68.6","68.6","40.369",0,"323.31",5030500000,133,"0.0344636",1,"-0.0278912","-0.108204","tr|Q86UY0|Q86UY0_HUMAN;sp|Q8NBS9|TXND5_HUMAN","tr|Q86UY0|Q86UY0_HUMAN;sp|Q8NBS9|TXND5_HUMAN",3293,"Q86UY0","Q86UY0_HUMAN",null,null,"TXNDC5"]
["17.5118",1,"17.5679",1,{"$nulls":3},"Golgi vesicle transport",{"$nulls":5},1,1,1,"9.2","9.2","9.2","13.875",0,"9.4782",8508000,1,"0.000737133",1,"-0.0280495","-0.00239833","tr|F5GWR1|F5GWR1_HUMAN;tr|F5GZH9|F5GZH9_HUMAN;tr|A0A0A0MTP0|A0A0A0MTP0_HUMAN;tr|A0A0A0MTK0|A0A0A0MTK0_HUMAN;sp|Q7Z6B0|CCD91_HUMAN","tr|F5GWR1|F5GWR1_HUMAN;tr|F5GZH9|F5GZH9_HUMAN;tr|A0A0A0MTP0|A0A0A0MTP0_HUMAN;tr|A0A0A0MTK0|A0A0A0MTK0_HUMAN;sp|Q7Z6B0|CCD91_HUMAN",3012,"F5GWR1","F5GWR1_HUMAN",null,null,"CCDC91"]
["16.1699",1,"16.2307",1,{"$nulls":3},"cell migration;protein phosphorylation","ATP binding","cytoplasm;Golgi apparatus;lamellipodium",{"$nulls":3},1,1,1,"1.6","1.6","1.6","82.857","0.0061827","2.6413",15809000,0,"0.000869854",1,"-0.0304146","-0.00282972","sp|Q8IZE3|PACE1_HUMAN","sp|Q8IZE3|PACE1_HUMAN",3178,"Q8IZE3","PACE1_HUMAN","Protein-associating with the carboxyl-terminal domain of ezrin",null,"SCYL3"]
["15.4304","14.0695","14.1206","15.4404",{"$nulls":3},"attachment of mitotic spindle microtubules to kinetochore;protein localization to kinetochore;protein localization to microtubule;sister chromatid biorientation","metal ion binding;nucleic acid binding","condensed chromosome;condensed chromosome kinetochore;cytoplasm;nuclear body;nucleoplasm;nucleus;spindle",{"$nulls":3},22,22,22,33,33,33,"89.098",0,"61.559",414820000,82,"0.00999687",1,"-0.0305119","-0.0321898","sp|Q96JM3|CHAP1_HUMAN;tr|S4R3K0|S4R3K0_HUMAN","sp|Q96JM3|CHAP1_HUMAN",3746,"Q96JM3","CHAP1_HUMAN","Chromosome alignment-maintaining phosphoprotein 1",null,"CHAMP1"]
["23.262","22.143","23.1801","22.2869",{"$nulls":3},"detection of calcium ion;Fc-epsilon receptor signaling pathway;glycogen catabolic process;inositol phosphate metabolic process;MAPK cascade;muscle contraction;negative regulation of peptidyl-threonine phosphorylation;negative regulation of ryanodine-sensitive calcium-release channel activity;platelet degranulation;positive regulation of cAMP biosynthetic process;positive regulation of cyclic nucleotide metabolic process;positive regulation of cyclic-nucleotide phosphodiesterase activity;positive regulation of peptidyl-threonine phosphorylation;positive regulation of phosphoprotein phosphatase activity;positive regulation of protein autophosphorylation;positive regulation of protein dephosphorylation;positive regulation of protein serine/threonine kinase activity;positive regulation of ryanodine-sensitive calcium-release channel activity;protein methylation;regulation of cardiac muscle contraction;regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;regulation of cell communication by electrical coupling involved in cardiac conduction;regulation of heart rate;regulation of nitric-oxide synthase activity;regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;regulation of rhodopsin mediated signaling pathway;regulation of ryanodine-sensitive calcium-release channel activity;response to calcium ion;Wnt signaling pathway, calcium modulating pathway","adenylate cyclase binding;calcium channel inhibitor activity;calcium ion binding;disordered domain specific binding;inositol-1,4,5-trisphosphate 3-kinase activity;ion channel binding;ligand-gated ion channel activity;protein kinase binding;protein phosphatase activator activity;protein serine/threonine kinase activator activity;Ras guanyl-nucleotide exchange factor activity;titin binding","catalytic complex;cytoplasm;cytosol;extracellular region;nucleoplasm;plasma membrane;protein complex;sarcomere;spindle pole","Adrenergic signaling in cardiomyocytes;Alcoholism;Aldosterone synthesis and secretion;Alzheimer disease;Amphetamine addiction;Apelin signaling pathway;Calcium signaling pathway;cAMP signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Circadian entrainment;C-type lectin receptor signaling pathway;Dopaminergic synapse;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;Gastric acid secretion;Glioma;Glucagon signaling pathway;GnRH signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Inflammatory mediator regulation of TRP channels;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Long-term potentiation;Melanogenesis;Neurotrophin signaling pathway;Olfactory transduction;Oocyte meiosis;Oxytocin signaling pathway;Pathways in cancer;Pertussis;Phosphatidylinositol signaling system;Phototransduction;Rap1 signaling pathway;Ras signaling pathway;Renin secretion;Salivary secretion;Tuberculosis;Vascular smooth muscle contraction",null,null,6,6,6,"60.4","60.4","60.4","16.837",0,"39.096",622540000,42,"0.0134961",1,"-0.0309925","-0.0432924","sp|P62158|CALM_HUMAN;tr|H0Y7A7|H0Y7A7_HUMAN;tr|E7ETZ0|E7ETZ0_HUMAN;tr|E7EMB3|E7EMB3_HUMAN;tr|F8WBR5|F8WBR5_HUMAN;tr|M0QZ52|M0QZ52_HUMAN;tr|G3V479|G3V479_HUMAN;tr|G3V361|G3V361_HUMAN;tr|Q96HY3|Q96HY3_HUMAN;tr|G3V226|G3V226_HUMAN;sp|P27482|CALL3_HUMAN;tr|C9J7T9|C9J7T9_HUMAN;sp|P02585|TNNC2_HUMAN","sp|P62158|CALM_HUMAN;tr|H0Y7A7|H0Y7A7_HUMAN;tr|E7ETZ0|E7ETZ0_HUMAN;tr|E7EMB3|E7EMB3_HUMAN;tr|F8WBR5|F8WBR5_HUMAN;tr|M0QZ52|M0QZ52_HUMAN;tr|G3V479|G3V479_HUMAN;tr|G3V361|G3V361_HUMAN;tr|Q96HY3|Q96HY3_HUMAN",1872,"P62158","CALM1_HUMAN","Calmodulin-1 {ECO:0000312|HGNC:HGNC:1442}",null,"CALM1"]
["21.9252","21.8456","22.2699","21.5657",{"$nulls":9},2,2,2,"52.3","52.3","52.3","10.027",0,"12.24",178660000,16,"0.0289762",1,"-0.0324078","-0.0914683","tr|F8VUY8|F8VUY8_HUMAN;sp|Q96QD8|S38A2_HUMAN","tr|F8VUY8|F8VUY8_HUMAN;sp|Q96QD8|S38A2_HUMAN",3793,"F8VUY8","F8VUY8_HUMAN",null,null,"SLC38A2"]
["14.7548",1,"14.8215",1,{"$nulls":4},"phosphatase binding","membrane",{"$nulls":3},2,2,2,"3.6","3.6","3.6","88.313","0.004884","2.8637",7728800,1,"0.00105076",1,"-0.03332","-0.00341753","sp|Q6ZMI0|PPR21_HUMAN;tr|F8W7E1|F8W7E1_HUMAN;tr|F8WBY8|F8WBY8_HUMAN;tr|F8WE40|F8WE40_HUMAN","sp|Q6ZMI0|PPR21_HUMAN;tr|F8W7E1|F8W7E1_HUMAN;tr|F8WBY8|F8WBY8_HUMAN;tr|F8WE40|F8WE40_HUMAN",2927,"Q6ZMI0","PPR21_HUMAN","Protein phosphatase 1 regulatory subunit 21",null,"PPP1R21"]
["19.8145","19.9264","19.8082","19.9996",{"$nulls":3},"2-oxoglutarate metabolic process;cellular protein metabolic process","2-hydroxyglutarate dehydrogenase activity","integral component of membrane;integral component of mitochondrial inner membrane;mitochondrial inner membrane;mitochondrion","Butanoate metabolism;Metabolic pathways",null,null,7,7,7,"21.4","21.4","21.4","50.315",0,"24.682",199890000,18,"0.101666",1,"-0.0334682","-0.301811","sp|Q9H9P8|L2HDH_HUMAN;tr|C9JVN9|C9JVN9_HUMAN;tr|G3V5S1|G3V5S1_HUMAN;tr|G3V272|G3V272_HUMAN","sp|Q9H9P8|L2HDH_HUMAN;tr|C9JVN9|C9JVN9_HUMAN",4280,"Q9H9P8","L2HDH_HUMAN","L-2-hydroxyglutarate dehydrogenase, mitochondrial",null,"L2HGDH"]
["20.2637","20.6424","20.3344","20.6395",{"$nulls":3},"cellular glucuronidation;flavone metabolic process;flavonoid glucuronidation;negative regulation of cellular glucuronidation;negative regulation of fatty acid metabolic process;negative regulation of glucuronosyltransferase activity;xenobiotic glucuronidation","enzyme binding;glucuronosyltransferase activity;protein heterodimerization activity;protein homodimerization activity;protein kinase C binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Ascorbate and aldarate metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pentose and glucuronate interconversions;Porphyrin and chlorophyll metabolism;Retinol metabolism;Steroid hormone biosynthesis",null,null,12,6,3,"38.9","18.7","7.7","59.809",0,"31.527",754610000,42,"0.0448118",1,"-0.0338783","-0.139318","sp|Q9HAW8|UD110_HUMAN;sp|P35504|UD15_HUMAN;tr|B5MCT4|B5MCT4_HUMAN","sp|Q9HAW8|UD110_HUMAN;sp|P35504|UD15_HUMAN",4299,"Q9HAW8","UD110_HUMAN","UDP-glucuronosyltransferase 1-10","DPGT 1-10;GT1*10;GT1.10;GT1-10","UGT1A10"]
["17.4648","19.1086","16.7946","19.8478",{"$nulls":3},"ATP hydrolysis coupled proton transport;cellular iron ion homeostasis;cellular response to increased oxygen levels;establishment of organelle localization;insulin receptor signaling pathway;ion transmembrane transport;pH reduction;positive regulation of bone resorption;positive regulation of ERK1 and ERK2 cascade;positive regulation of exocytosis;positive regulation of osteoblast differentiation;positive regulation of osteoclast development;proton transport;transferrin transport","ATP binding;proton-transporting ATP synthase activity, rotational mechanism;proton-transporting ATPase activity, rotational mechanism;Rab GTPase binding;transporter activity","endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;endosome membrane;extracellular exosome;integral component of membrane;proton-transporting two-sector ATPase complex;proton-transporting V-type ATPase, V1 domain","Epithelial cell signaling in Helicobacter pylori infection;Hepatitis B;Human papillomavirus infection;Lysosome;Metabolic pathways;Oxidative phosphorylation;Phagosome;Rheumatoid arthritis;Tuberculosis;Vibrio cholerae infection",null,null,3,3,3,"9.1","9.1","9.1","52.025",0,"12.409",101400000,5,"0.00615249",1,"-0.0344934","-0.0198954","sp|Q15904|VAS1_HUMAN;tr|A0A0C4DGX8|A0A0C4DGX8_HUMAN;tr|A6QRJ1|A6QRJ1_HUMAN;tr|A6NLC6|A6NLC6_HUMAN","sp|Q15904|VAS1_HUMAN;tr|A0A0C4DGX8|A0A0C4DGX8_HUMAN",2531,"Q15904","VAS1_HUMAN","V-type proton ATPase subunit S1",{"$f":"-ATPase subunit S294","v":{"$error":"#NAME?"}},"ATP6AP1"]
["23.7706","23.3843","24.0146","23.21",{"$nulls":3},"protein homotetramerization;visual perception;xenobiotic catabolic process","mRNA 3'-UTR binding;NADPH binding;NADPH:quinone reductase activity;zinc ion binding","cytosol;extracellular exosome",{"$nulls":3},17,17,17,"67.2","67.2","67.2","35.206",0,"83.915",2100300000,104,"0.0246458",1,"-0.0348701","-0.0781395","sp|Q08257|QOR_HUMAN;tr|A6NP24|A6NP24_HUMAN;tr|C9JH92|C9JH92_HUMAN","sp|Q08257|QOR_HUMAN;tr|A6NP24|A6NP24_HUMAN;tr|C9JH92|C9JH92_HUMAN",2127,"Q08257","QOR_HUMAN","Quinone oxidoreductase",null,"CRYZ"]
["21.3096","20.9279","21.4282","20.881",{"$nulls":3},"inner mitochondrial membrane organization;mitochondrial calcium ion homeostasis;mitochondrial calcium ion transmembrane transport;mitochondrial calcium uptake;mitochondrial respiratory chain complex III biogenesis;mitochondrial respiratory chain complex IV biogenesis;protein insertion into mitochondrial membrane;protein insertion into mitochondrial membrane from inner side","ribosome binding","mitochondrial inner membrane;mitochondrial matrix",{"$nulls":3},6,6,6,"23.7","23.7","23.7","32.544",0,"17.691",604690000,36,"0.0342502",1,"-0.035881","-0.107556","sp|Q8WWC4|CB047_HUMAN;tr|H7C0V0|H7C0V0_HUMAN","sp|Q8WWC4|CB047_HUMAN;tr|H7C0V0|H7C0V0_HUMAN",3452,"Q8WWC4","MAIP1_HUMAN","m-AAA protease-interacting protein 1, mitochondrial {ECO:0000303|PubMed:27642048}",null,"MAIP1"]
["23.4381","23.4367","23.7193","23.2297",{"$nulls":3},"4-hydroxyproline metabolic process;animal organ senescence;brown fat cell differentiation;cell redox homeostasis;cellular protein modification process;cellular response to hypoxia;cellular response to oxidative stress;chaperone mediated protein folding requiring cofactor;endoplasmic reticulum unfolded protein response;extracellular matrix organization;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;protein folding;protein folding in endoplasmic reticulum;protein maturation by protein folding;release of sequestered calcium ion into cytosol;response to endoplasmic reticulum stress;response to temperature stimulus","disulfide oxidoreductase activity;oxidoreductase activity;oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;protein disulfide isomerase activity;protein disulfide oxidoreductase activity","dendrite;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;intracellular membrane-bounded organelle;membrane","Protein processing in endoplasmic reticulum;Vibrio cholerae infection",null,null,17,17,16,"40.8","40.8","38.5","54.392",0,"114.21",2126900000,98,"0.0489787",1,"-0.0371323","-0.151692","sp|Q96HE7|ERO1A_HUMAN;tr|G3V3E6|G3V3E6_HUMAN;tr|G3V2H0|G3V2H0_HUMAN;tr|G3V5B3|G3V5B3_HUMAN;tr|G3V503|G3V503_HUMAN","sp|Q96HE7|ERO1A_HUMAN",3716,"Q96HE7","ERO1A_HUMAN","ERO1-like protein alpha","RO1-L;RO1-L-alpha","ERO1A"]
["22.478","22.4495","22.6078","22.3953",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;aorta development;cellular response to carbon monoxide;cellular response to dopamine;cellular response to nitric oxide;cellular response to X-ray;coronary vasculature development;dynamin family protein polymerization involved in mitochondrial fission;endocytosis;G2/M transition of mitotic cell cycle;Golgi to plasma membrane transport;G-protein coupled receptor internalization;macropinocytosis;membrane fusion;membrane organization;mitochondrial fission;negative regulation of membrane tubulation;negative regulation of non-motile cilium assembly;negative regulation of transforming growth factor beta receptor signaling pathway;neuron projection morphogenesis;phagocytosis;positive regulation of apoptotic process;positive regulation of lamellipodium assembly;positive regulation of nitric oxide biosynthetic process;positive regulation of phagocytosis;positive regulation of sodium:potassium-exchanging ATPase activity;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of transcription, DNA-templated;receptor internalization;receptor-mediated endocytosis;regulation of axon extension;regulation of Golgi organization;regulation of nitric-oxide synthase activity;regulation of Rac protein signal transduction;regulation of transcription, DNA-templated;response to cocaine;response to light stimulus;signal transduction;spermatogenesis;synaptic vesicle transport;transferrin transport;ventricular septum development","D2 dopamine receptor binding;enzyme binding;GTP binding;GTPase activity;microtubule binding;nitric-oxide synthase binding;phosphatidylinositol 3-kinase regulatory subunit binding;protein complex binding;protein kinase binding;SH3 domain binding;WW domain binding","centrosome;clathrin-coated endocytic vesicle;clathrin-coated pit;cytosol;endocytic vesicle membrane;endosome;extracellular exosome;focal adhesion;Golgi apparatus;Golgi membrane;growth cone;lamellipodium;microtubule;midbody;mitochondrial membrane;nucleus;perinuclear region of cytoplasm;phagocytic cup;phagocytic vesicle membrane;photoreceptor inner segment;plasma membrane;postsynaptic density;postsynaptic membrane;protein complex;ruffle membrane;trans-Golgi network","Bacterial invasion of epithelial cells;Endocrine and other factor-regulated calcium reabsorption;Endocytosis;Fc gamma R-mediated phagocytosis;Phospholipase D signaling pathway;Synaptic vesicle cycle",null,null,26,26,18,"34.4","34.4","25.6","98.063",0,"214.55",2200400000,122,"0.120295",1,"-0.0378122","-0.352628","sp|P50570|DYN2_HUMAN;tr|A0A0D9SFB1|A0A0D9SFB1_HUMAN;tr|A0A0D9SFE4|A0A0D9SFE4_HUMAN;sp|Q05193|DYN1_HUMAN;tr|E5RHK8|E5RHK8_HUMAN;sp|Q9UQ16|DYN3_HUMAN;tr|E5RIK2|E5RIK2_HUMAN;tr|K7EPK9|K7EPK9_HUMAN;tr|H7C5U0|H7C5U0_HUMAN","sp|P50570|DYN2_HUMAN",1630,"P50570","DYN2_HUMAN","Dynamin-2",null,"DNM2"]
["26.4978","26.5115","26.673","26.4134",{"$nulls":3},"CTP biosynthetic process;GTP biosynthetic process;UTP biosynthetic process","ATP binding;nucleoside diphosphate kinase activity","cytosol",{"$nulls":3},16,16,6,"71.9","71.9",24,"32.642",0,"297.36",15557000000,426,"0.099815",1,"-0.0385714","-0.296707","tr|Q32Q12|Q32Q12_HUMAN;sp|P22392|NDKB_HUMAN;tr|J3KPD9|J3KPD9_HUMAN;sp|O60361|NDK8_HUMAN;tr|F6XY72|F6XY72_HUMAN","tr|Q32Q12|Q32Q12_HUMAN;sp|P22392|NDKB_HUMAN;tr|J3KPD9|J3KPD9_HUMAN;sp|O60361|NDK8_HUMAN",5291,"Q32Q12","Q32Q12_HUMAN","Nucleoside diphosphate kinase {ECO:0000256|RuleBase:RU004013}"]
["22.3263","22.5977","22.6772","22.3262",{"$nulls":3},"post-Golgi vesicle-mediated transport;protein transport",null,"extracellular exosome;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;recycling endosome membrane;trans-Golgi network membrane;transport vesicle",{"$nulls":3},4,4,4,"14.3","14.3","14.3","36.648",0,"54.566",396910000,24,"0.0582918",1,"-0.039712","-0.179049","sp|O15127|SCAM2_HUMAN;tr|H3BV04|H3BV04_HUMAN;tr|H3BN93|H3BN93_HUMAN;tr|H3BUB6|H3BUB6_HUMAN;tr|H3BPL9|H3BPL9_HUMAN","sp|O15127|SCAM2_HUMAN;tr|H3BV04|H3BV04_HUMAN;tr|H3BN93|H3BN93_HUMAN;tr|H3BUB6|H3BUB6_HUMAN;tr|H3BPL9|H3BPL9_HUMAN",328,"O15127","SCAM2_HUMAN","Secretory carrier-associated membrane protein 2","ecretory carrier membrane protein 2","SCAMP2"]
["20.0364","20.6653","20.464","20.3176",{"$nulls":3},"axon extension;cellular response to insulin stimulus;cognition;dendrite extension;Fc-gamma receptor signaling pathway involved in phagocytosis;lamellipodium assembly;modification of synaptic structure;negative regulation of synaptic vesicle recycling;neutrophil degranulation;positive regulation of Arp2/3 complex-mediated actin nucleation;positive regulation of axon extension;positive regulation of dendrite development;positive regulation of neurotrophin TRK receptor signaling pathway;positive regulation of ruffle assembly;Rac protein signal transduction;regulation of cell shape;regulation of translation;response to electrical stimulus;ruffle organization;vascular endothelial growth factor receptor signaling pathway","actin filament binding;protein complex binding;Rac GTPase binding;RNA 7-methylguanosine cap binding","axonal growth cone;central region of growth cone;cytosol;dendritic growth cone;dendritic spine;excitatory synapse;extracellular exosome;extracellular region;filopodium tip;focal adhesion;lamellipodium;mRNA cap binding complex;neuron projection;neuronal cell body;perinuclear region of cytoplasm;peripheral region of growth cone;ruffle;SCAR complex;secretory granule lumen;specific granule lumen;terminal bouton;tertiary granule lumen","Regulation of actin cytoskeleton;RNA transport",null,null,16,16,6,"16.1","16.1","6.9","145.18",0,"54.859",1601300000,75,"0.0396272",1,"-0.0399656","-0.123799","sp|Q7L576|CYFP1_HUMAN;tr|A0A0G2JR96|A0A0G2JR96_HUMAN;tr|A0A0G2JQT1|A0A0G2JQT1_HUMAN;tr|H0YL50|H0YL50_HUMAN;tr|A0A087WVE1|A0A087WVE1_HUMAN;tr|A0A087WTQ3|A0A087WTQ3_HUMAN;tr|A0A087WWZ1|A0A087WWZ1_HUMAN;tr|A0A0G2JRX2|A0A0G2JRX2_HUMAN;tr|A0A087WU52|A0A087WU52_HUMAN;tr|A0A0G2JRV9|A0A0G2JRV9_HUMAN;tr|A0A087WWL1|A0A087WWL1_HUMAN;tr|A0A087X0D6|A0A087X0D6_HUMAN","sp|Q7L576|CYFP1_HUMAN;tr|A0A0G2JR96|A0A0G2JR96_HUMAN;tr|A0A0G2JQT1|A0A0G2JQT1_HUMAN",2968,"Q7L576","CYFP1_HUMAN","Cytoplasmic FMR1-interacting protein 1",null,"CYFIP1"]
["19.4173","20.4322","19.3765","20.5531",{"$nulls":3},"C21-steroid hormone biosynthetic process;cellular response to cAMP;cellular response to forskolin;cholesterol metabolic process;hormone biosynthetic process;small molecule metabolic process;sterol metabolic process","2 iron, 2 sulfur cluster binding;electron transfer activity;iron ion binding","mitochondrial matrix;mitochondrion",{"$nulls":3},2,2,2,"16.3","16.3","16.3","19.393",0,"93.056",144910000,8,"0.0161226",1,"-0.0400658","-0.0515723","sp|P10109|ADX_HUMAN","sp|P10109|ADX_HUMAN",963,"P10109","ADX_HUMAN","Adrenodoxin, mitochondrial",null,"FDX1"]
["20.5019","19.775","20.9112","19.4461",{"$nulls":3},"cellular response to hypoxia;heterochromatin organization;nucleosome assembly;regulation of cell proliferation;regulation of nucleus size;regulation of transcription, DNA-templated","DNA binding;nucleosome binding","chromosome;nuclear speck;nucleosome;nucleus",{"$nulls":3},21,21,21,47,47,47,"61.206",0,"164.64",3344100000,222,"0.0153587",1,"-0.0402069","-0.0491689","sp|Q5SSJ5|HP1B3_HUMAN;tr|X6RGJ2|X6RGJ2_HUMAN;tr|B0QZK4|B0QZK4_HUMAN;tr|Q5SWC8|Q5SWC8_HUMAN;tr|B0QZK8|B0QZK8_HUMAN;tr|B0QZK9|B0QZK9_HUMAN","sp|Q5SSJ5|HP1B3_HUMAN;tr|X6RGJ2|X6RGJ2_HUMAN;tr|B0QZK4|B0QZK4_HUMAN;tr|Q5SWC8|Q5SWC8_HUMAN",2713,"Q5SSJ5","HP1B3_HUMAN","Heterochromatin protein 1-binding protein 3",null,"HP1BP3"]
["23.1877","23.9652","23.7841","23.4516",{"$nulls":3},"diphosphate metabolic process;regulation of mitochondrial membrane potential;tRNA aminoacylation for protein translation","inorganic diphosphatase activity;magnesium ion binding;protein serine/threonine phosphatase activity","extracellular exosome;mitochondrial matrix","Oxidative phosphorylation",null,null,13,13,12,"55.4","55.4","50.6","37.92",0,"89.019",2496000000,99,"0.0310951",1,"-0.0414124","-0.0979506","sp|Q9H2U2|IPYR2_HUMAN;tr|D6R967|D6R967_HUMAN;tr|H0Y9D8|H0Y9D8_HUMAN;tr|D6RGV9|D6RGV9_HUMAN;tr|D6RGI1|D6RGI1_HUMAN;tr|D6RAD3|D6RAD3_HUMAN;tr|H0YAK2|H0YAK2_HUMAN","sp|Q9H2U2|IPYR2_HUMAN;tr|D6R967|D6R967_HUMAN;tr|H0Y9D8|H0Y9D8_HUMAN",4177,"Q9H2U2","IPYR2_HUMAN","Inorganic pyrophosphatase 2, mitochondrial",null,"PPA2"]
["15.7551","17.3436","15.7705","17.4119",{"$nulls":3},"selenocysteine incorporation","GTP binding;GTPase activity;ribonucleoprotein complex binding;selenocysteine insertion sequence binding;translation elongation factor activity;tRNA binding","intracellular ribonucleoprotein complex;mitochondrion;nucleus",{"$nulls":3},18,18,18,"37.8","37.8","37.8","65.304",0,"74.698",1154900000,122,"0.0114027",1,"-0.0418692","-0.0366603","sp|P57772|SELB_HUMAN;tr|C9J8T0|C9J8T0_HUMAN","sp|P57772|SELB_HUMAN;tr|C9J8T0|C9J8T0_HUMAN",1798,"P57772","SELB_HUMAN","Selenocysteine-specific elongation factor",null,"EEFSEC"]
["24.9665","24.6427","25.3086","24.3862",{"$nulls":3},"gluconeogenesis;malate metabolic process;NADH metabolic process;oxaloacetate metabolic process;tricarboxylic acid cycle","diiodophenylpyruvate reductase activity;L-malate dehydrogenase activity;malic enzyme activity;NAD binding","cytosol;extracellular exosome;extracellular space;mitochondrion;myelin sheath","Carbon metabolism;Citrate cycle (TCA cycle);Cysteine and methionine metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Proximal tubule bicarbonate reclamation;Pyruvate metabolism",null,null,13,13,13,"52.1","52.1","52.1","36.426",0,"152.98",3611500000,138,"0.027703",1,"-0.0427971","-0.087561","sp|P40925|MDHC_HUMAN;tr|B9A041|B9A041_HUMAN;tr|B8ZZ51|B8ZZ51_HUMAN;tr|C9JF79|C9JF79_HUMAN;tr|C9JRL4|C9JRL4_HUMAN;tr|C9JLV6|C9JLV6_HUMAN","sp|P40925|MDHC_HUMAN;tr|B9A041|B9A041_HUMAN;tr|B8ZZ51|B8ZZ51_HUMAN",1443,"P40925","MDHC_HUMAN","Malate dehydrogenase, cytoplasmic",null,"MDH1"]
["19.0322","16.6858","18.8174","16.9875",{"$nulls":3},"cellular protein metabolic process;intracellular protein transport;positive regulation of protein catabolic process;toxin transport;vesicle-mediated transport","ADP-ribosylation factor binding;protein heterodimerization activity","clathrin adaptor complex;early endosome membrane;endosome membrane;Golgi apparatus;intracellular membrane-bounded organelle;membrane;nucleoplasm;protein complex","Lysosome",null,null,6,6,6,"12.4","12.4","12.4","70.383",0,"39.34",109460000,7,"0.00906454",1,"-0.0434704","-0.0292176","sp|Q9UJY5|GGA1_HUMAN;tr|B0QYR6|B0QYR6_HUMAN;tr|B0QYS5|B0QYS5_HUMAN;tr|B0QYS2|B0QYS2_HUMAN;tr|B0QYS3|B0QYS3_HUMAN","sp|Q9UJY5|GGA1_HUMAN;tr|B0QYR6|B0QYR6_HUMAN",4774,"Q9UJY5","GGA1_HUMAN","ADP-ribosylation factor-binding protein GGA1",null,"GGA1"]
["17.6396",1,"17.7305",1,{"$nulls":4},"metal ion binding",{"$nulls":4},4,4,4,5,5,5,"161.91",0,"12.135",123520000,14,"0.00118468",1,"-0.0454521","-0.00385249","tr|A0A0J9YX88|A0A0J9YX88_HUMAN;tr|E9PJ24|E9PJ24_HUMAN;tr|B7ZM65|B7ZM65_HUMAN;tr|F8WEF5|F8WEF5_HUMAN;tr|A0A0J9YYB5|A0A0J9YYB5_HUMAN;tr|A0A0J9YWD5|A0A0J9YWD5_HUMAN;sp|Q9P1Y6|PHRF1_HUMAN","tr|A0A0J9YX88|A0A0J9YX88_HUMAN;tr|E9PJ24|E9PJ24_HUMAN;tr|B7ZM65|B7ZM65_HUMAN;tr|F8WEF5|F8WEF5_HUMAN;tr|A0A0J9YYB5|A0A0J9YYB5_HUMAN;tr|A0A0J9YWD5|A0A0J9YWD5_HUMAN;sp|Q9P1Y6|PHRF1_HUMAN",4628,"A0A0J9YX88","A0A0J9YX88_HUMAN",null,null,"PHRF1"]
["22.1926","22.1426","22.4","22.0275",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrion;ribosome",{"$nulls":3},4,4,4,26,26,26,"20.116",0,"16.237",449930000,34,"0.0814824",1,"-0.0461531","-0.24555","sp|P82663|RT25_HUMAN;tr|E7EPW2|E7EPW2_HUMAN","sp|P82663|RT25_HUMAN;tr|E7EPW2|E7EPW2_HUMAN",1989,"P82663","RT25_HUMAN","28S ribosomal protein S25, mitochondrial","25mt;RP-S25","MRPS25"]
["22.9","23.137","22.8941","23.237",{"$nulls":3},"threonyl-tRNA aminoacylation;translation;tRNA aminoacylation for protein translation","ATP binding;protein homodimerization activity;threonine-tRNA ligase activity;tRNA binding","actin cytoskeleton;cytoplasm;cytosol;extracellular exosome","Aminoacyl-tRNA biosynthesis",null,null,29,29,27,"45.2","45.2",43,"83.434",0,"209.01",3810500000,191,"0.0744523",1,"-0.0470276","-0.225617","sp|P26639|SYTC_HUMAN;tr|D6R9F8|D6R9F8_HUMAN;tr|D6RCA5|D6RCA5_HUMAN;tr|D6RDJ6|D6RDJ6_HUMAN;tr|D6RBR8|D6RBR8_HUMAN;tr|D6RJ97|D6RJ97_HUMAN;tr|D6RHV7|D6RHV7_HUMAN;tr|D6RCS6|D6RCS6_HUMAN","sp|P26639|SYTC_HUMAN",1243,"P26639","SYTC_HUMAN","Threonine--tRNA ligase, cytoplasmic",null,"TARS"]
["17.2851","18.5383","18.0272","17.8918",{"$nulls":3},"histidyl-tRNA aminoacylation;translation;tRNA aminoacylation for protein translation","ATP binding;histidine-tRNA ligase activity;protein homodimerization activity;RNA binding","mitochondrial matrix;mitochondrion","Aminoacyl-tRNA biosynthesis",null,null,9,3,3,"17.8","6.3","6.3","56.888",0,"15.39",61629000,12,"0.0239369",1,"-0.047864","-0.0759471","sp|P49590|SYHM_HUMAN;tr|B4DQ67|B4DQ67_HUMAN","sp|P49590|SYHM_HUMAN;tr|B4DQ67|B4DQ67_HUMAN",1582,"P49590","SYHM_HUMAN","Probable histidine--tRNA ligase, mitochondrial",null,"HARS2"]
["20.1252","20.7371","20.3299","20.6293",{"$nulls":3},"cellular response to interferon-beta;cellular response to oxidative stress;liver regeneration;mitochondrial mRNA catabolic process;mitochondrial mRNA polyadenylation;mitochondrial RNA 3'-end processing;mitochondrial RNA 5'-end processing;mitochondrial RNA catabolic process;mitochondrion morphogenesis;mitotic cell cycle arrest;mRNA catabolic process;negative regulation of growth;nuclear polyadenylation-dependent mRNA catabolic process;positive regulation of miRNA catabolic process;positive regulation of mitochondrial RNA catabolic process;positive regulation of mRNA catabolic process;protein homooligomerization;protein homotrimerization;regulation of cellular respiration;regulation of cellular senescence;response to cAMP;response to growth hormone;RNA catabolic process;RNA import into mitochondrion;RNA polyadenylation;rRNA import into mitochondrion","3'-5'-exoribonuclease activity;miRNA binding;poly(G) binding;poly(U) RNA binding;polyribonucleotide nucleotidyltransferase activity;RNA binding","cytoplasm;cytosol;endoplasmic reticulum membrane;mitochondrial degradosome;mitochondrial intermembrane space;mitochondrion;nucleus;polysomal ribosome","RNA degradation",null,null,20,20,20,"29.5","29.5","29.5","85.95",0,"61.123",505540000,62,"0.0458002",1,"-0.0484571","-0.142261","sp|Q8TCS8|PNPT1_HUMAN;tr|H7BXF6|H7BXF6_HUMAN;tr|H7C3C5|H7C3C5_HUMAN;tr|F8WBI3|F8WBI3_HUMAN","sp|Q8TCS8|PNPT1_HUMAN",3377,"Q8TCS8","PNPT1_HUMAN","Polyribonucleotide nucleotidyltransferase 1, mitochondrial",null,"PNPT1"]
["23.3968","23.2751","23.5564","23.2134",{"$nulls":3},"alpha-linolenic acid metabolic process;bile acid metabolic process;fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA oxidase;neutrophil degranulation;very long-chain fatty acid metabolic process","acetate CoA-transferase activity;acetyl-CoA C-acyltransferase activity;palmitoyl-CoA oxidase activity","extracellular region;intracellular membrane-bounded organelle;membrane;peroxisomal matrix;peroxisome;specific granule lumen","alpha-Linolenic acid metabolism;Biosynthesis of unsaturated fatty acids;Fatty acid degradation;Fatty acid metabolism;Metabolic pathways;Peroxisome;PPAR signaling pathway;Valine, leucine and isoleucine degradation",null,null,10,10,10,42,42,42,"44.292",0,"106.05",1713100000,67,"0.0897857",1,"-0.0489254","-0.268861","sp|P09110|THIK_HUMAN;tr|H7C131|H7C131_HUMAN;tr|C9JDE9|C9JDE9_HUMAN;tr|H0Y4D4|H0Y4D4_HUMAN;tr|B4DVF4|B4DVF4_HUMAN;tr|F2Z2Q6|F2Z2Q6_HUMAN;tr|F2Z3P7|F2Z3P7_HUMAN","sp|P09110|THIK_HUMAN;tr|H7C131|H7C131_HUMAN;tr|C9JDE9|C9JDE9_HUMAN;tr|H0Y4D4|H0Y4D4_HUMAN",940,"P09110","THIK_HUMAN","3-ketoacyl-CoA thiolase, peroxisomal",null,"ACAA1"]
["22.1191","22.4839","22.292","22.4103",{"$nulls":4},"DNA binding;lamin binding","cytoplasm;integral component of membrane;membrane;nuclear envelope;nuclear inner membrane;nuclear membrane;nucleus",{"$nulls":3},23,12,12,59,"29.3","29.3","50.67",0,"260.67",3532800000,282,"0.0861708",1,"-0.0496168","-0.258742","sp|P42167|LAP2B_HUMAN;tr|G5E972|G5E972_HUMAN;tr|H0YJH7|H0YJH7_HUMAN","sp|P42167|LAP2B_HUMAN;tr|G5E972|G5E972_HUMAN",1465,"P42167","LAP2B_HUMAN","Lamina-associated polypeptide 2, isoforms beta/gamma",null,"TMPO"]
["23.4917","23.449","23.6926","23.3518",{"$nulls":3},"cell differentiation;cellular iron ion homeostasis;negative regulation of catalytic activity;neutrophil degranulation;positive regulation of RNA polymerase II transcriptional preinitiation complex assembly;post-translational protein modification;protein ubiquitination;SCF complex assembly","TBP-class protein binding","cullin-RING ubiquitin ligase complex;cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;Golgi apparatus;membrane;nucleoplasm;nucleus;secretory granule lumen;ubiquitin ligase complex",{"$nulls":3},43,43,43,"42.8","42.8","42.8","136.37",0,"323.31",6490900000,272,"0.101771",1,"-0.0518894","-0.302102","sp|Q86VP6|CAND1_HUMAN;tr|A0A0C4DGH5|A0A0C4DGH5_HUMAN;tr|H0YH27|H0YH27_HUMAN;sp|O75155|CAND2_HUMAN;tr|F5H6I6|F5H6I6_HUMAN;tr|F8WBB8|F8WBB8_HUMAN","sp|Q86VP6|CAND1_HUMAN;tr|A0A0C4DGH5|A0A0C4DGH5_HUMAN",3063,"Q86VP6","CAND1_HUMAN","Cullin-associated NEDD8-dissociated protein 1",null,"CAND1"]
["24.5096","24.7364","24.6476","24.7032",{"$nulls":3},"animal organ regeneration;brainstem development;cerebellum development;cerebral cortex development;'de novo' IMP biosynthetic process;dihydrofolate metabolic process;nucleobase-containing compound metabolic process;nucleoside metabolic process;purine ribonucleoside monophosphate biosynthetic process;response to inorganic substance;tetrahydrofolate biosynthetic process","cadherin binding;IMP cyclohydrolase activity;phosphoribosylaminoimidazolecarboxamide formyltransferase activity;protein homodimerization activity","cytosol;extracellular exosome;membrane;mitochondrion","Antifolate resistance;Metabolic pathways;One carbon pool by folate;Purine metabolism",null,null,36,36,36,75,75,75,"64.615",0,"323.31",8641800000,298,"0.15656",1,"-0.0524359","-0.449101","sp|P31939|PUR9_HUMAN;tr|H7C1S2|H7C1S2_HUMAN;tr|C9JLK0|C9JLK0_HUMAN;tr|F8WEF0|F8WEF0_HUMAN","sp|P31939|PUR9_HUMAN",1337,"P31939","PUR9_HUMAN","Bifunctional purine biosynthesis protein PURH",null,"ATIC"]
["24.4956","24.8791","24.6851","24.7953",{"$nulls":3},"histone mRNA metabolic process;IRES-dependent viral translational initiation;nuclear histone mRNA catabolic process;protein localization to cytoplasmic stress granule;tRNA 3'-end processing;tRNA 5'-leader removal;tRNA export from nucleus;tRNA modification;tRNA processing","mRNA binding;poly(U) RNA binding;RNA binding;sequence-specific mRNA binding;tRNA binding","cytoplasm;intracellular ribonucleoprotein complex;nuclear chromosome, telomeric region;nucleus","Systemic lupus erythematosus",null,null,16,16,16,"36.3","36.3","36.3","46.836",0,"114.68",5214700000,118,"0.08828",1,"-0.0527983","-0.264652","sp|P05455|LA_HUMAN;tr|E7ERC4|E7ERC4_HUMAN;tr|E9PGX9|E9PGX9_HUMAN;tr|E9PFL9|E9PFL9_HUMAN","sp|P05455|LA_HUMAN;tr|E7ERC4|E7ERC4_HUMAN",866,"P05455","LA_HUMAN","Lupus La protein",null,"SSB"]
["22.5992","22.2384","22.6434","22.3014",{"$nulls":5},"mitochondrion;nucleolus",{"$nulls":3},6,6,6,"49.3","49.3","49.3","25.717",0,"55.991",375870000,32,"0.0709267",1,"-0.0535727","-0.215549","tr|C9JAZ1|C9JAZ1_HUMAN;sp|O75431|MTX2_HUMAN;tr|C9JNK6|C9JNK6_HUMAN;tr|F8WE26|F8WE26_HUMAN","tr|C9JAZ1|C9JAZ1_HUMAN;sp|O75431|MTX2_HUMAN;tr|C9JNK6|C9JNK6_HUMAN",568,"C9JAZ1","C9JAZ1_HUMAN",null,null,"MTX2"]
["17.5107",1,"17.6194",1,{"$nulls":3},"anterograde axonal transport;anterograde synaptic vesicle transport;endosome to melanosome transport;eye development;melanosome organization;melanosome transport;neuron projection development;pigmentation;platelet activation;platelet dense granule organization",null,"axon cytoplasm;BLOC-1 complex;cytosol;transport vesicle",{"$nulls":3},1,1,1,"9.4","9.4","9.4","21.255","0.000254","6.6988",15174000,6,"0.00142684",1,"-0.0543346","-0.0046387","sp|Q6QNY0|BL1S3_HUMAN","sp|Q6QNY0|BL1S3_HUMAN",2891,"Q6QNY0","BL1S3_HUMAN","Biogenesis of lysosome-related organelles complex 1 subunit 3","LOC-1 subunit 3","BLOC1S3"]
["20.5907","20.8927","20.9596","20.6335",{"$nulls":3},"aging;COPII vesicle coating;ER to Golgi vesicle-mediated transport;immune response;neutrophil degranulation;positive regulation of apoptotic signaling pathway;positive regulation of proteolysis involved in cellular protein catabolic process;proteolysis;proteolysis involved in cellular protein catabolic process;response to organic substance;T cell mediated cytotoxicity","chaperone binding;chloride ion binding;cysteine-type endopeptidase activity;cysteine-type peptidase activity;identical protein binding;peptidase activator activity involved in apoptotic process;phosphatase binding;protein self-association;serine-type endopeptidase activity","azurophil granule lumen;centrosome;COPII-coated ER to Golgi transport vesicle;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;extracellular region;extracellular space;Golgi membrane;intracellular membrane-bounded organelle;lysosome;membrane;nucleoplasm","Apoptosis;Lysosome",null,null,6,6,6,"18.6","18.6","18.6","51.853",0,"16.999",322920000,35,"0.0820178",1,"-0.0549068","-0.24706","sp|P53634|CATC_HUMAN;tr|H0YCY8|H0YCY8_HUMAN","sp|P53634|CATC_HUMAN;tr|H0YCY8|H0YCY8_HUMAN",1719,"P53634","CATC_HUMAN","Dipeptidyl peptidase 1",null,"CTSC"]
["20.7965",1,"20.9079",1,{"$nulls":5},"cytosol;nucleus;plasma membrane",{"$nulls":3},1,1,1,"14.2","14.2","14.2","10.897","0.00024242","5.7166",35301000,1,"0.00122104",1,"-0.0557375","-0.00397056","sp|Q9GZP8|IMUP_HUMAN","sp|Q9GZP8|IMUP_HUMAN",4110,"Q9GZP8","IMUP_HUMAN","Immortalization up-regulated protein",null,"IMUP"]
["24.1338","23.9462","24.3192","23.8736",{"$nulls":3},"mitochondrial transport;transport","phosphate:proton symporter activity;protein complex binding","extracellular exosome;integral component of plasma membrane;membrane;mitochondrial inner membrane;mitochondrion;myelin sheath",{"$nulls":3},13,13,13,"34.8","34.8","34.8","40.094",0,"133.5",9552000000,315,"0.0771549",1,"-0.0563993","-0.233302","sp|Q00325|MPCP_HUMAN;tr|F8VVM2|F8VVM2_HUMAN;tr|F8VZL5|F8VZL5_HUMAN;tr|F8VWR4|F8VWR4_HUMAN;tr|F8VWQ0|F8VWQ0_HUMAN","sp|Q00325|MPCP_HUMAN;tr|F8VVM2|F8VVM2_HUMAN",2028,"Q00325","MPCP_HUMAN","Phosphate carrier protein, mitochondrial",null,"SLC25A3"]
["22.8181","23.532","23.1938","23.2701",{"$nulls":3},"apoptotic signaling pathway;cellular response to interferon-beta;cellular response to retinoic acid;extrinsic apoptotic signaling pathway;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;negative regulation of cell growth;negative regulation of intrinsic apoptotic signaling pathway;negative regulation of transcription, DNA-templated;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of peptidase activity;positive regulation of protein catabolic process;protein import into mitochondrial inner membrane;reactive oxygen species metabolic process","ATP binding;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity","cytoplasm;extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial membrane;mitochondrial respiratory chain;mitochondrial respiratory chain complex I;mitochondrion;nucleoplasm","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,5,5,5,"39.6","39.6","39.6","16.698",0,"20.75",715350000,33,"0.0512983",1,"-0.0569086","-0.158544","sp|Q9P0J0|NDUAD_HUMAN;tr|B4DEZ3|B4DEZ3_HUMAN;tr|K7EJE1|K7EJE1_HUMAN;tr|E7ENQ6|E7ENQ6_HUMAN;tr|U3KQP3|U3KQP3_HUMAN","sp|Q9P0J0|NDUAD_HUMAN;tr|B4DEZ3|B4DEZ3_HUMAN;tr|K7EJE1|K7EJE1_HUMAN;tr|E7ENQ6|E7ENQ6_HUMAN",4615,"Q9P0J0","NDUAD_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13",null,"NDUFA13"]
["21.6019","20.7939","21.6949","20.8149",{"$nulls":3},"abortive mitotic cell cycle;activation of MAPK activity;atrioventricular canal development;axon guidance;Bergmann glial cell differentiation;brain development;cellular response to epidermal growth factor stimulus;cellular response to mechanical stimulus;cerebellar cortex formation;DNA damage checkpoint;ephrin receptor signaling pathway;epidermal growth factor receptor signaling pathway;ERBB signaling pathway;face morphogenesis;fibroblast growth factor receptor signaling pathway;genitalia development;glucose homeostasis;heart development;homeostasis of number of cells within a tissue;hormone metabolic process;hormone-mediated signaling pathway;inner ear development;integrin-mediated signaling pathway;intestinal epithelial cell migration;leukocyte migration;megakaryocyte development;microvillus organization;multicellular organism growth;multicellular organismal reproductive process;negative regulation of cell adhesion mediated by integrin;negative regulation of cortisol secretion;negative regulation of growth hormone secretion;negative regulation of insulin secretion;neurotrophin TRK receptor signaling pathway;organ growth;peptidyl-tyrosine dephosphorylation;platelet activation;platelet formation;platelet-derived growth factor receptor signaling pathway;positive regulation of ERK1 and ERK2 cascade;positive regulation of glucose import in response to insulin stimulus;positive regulation of hormone secretion;positive regulation of mitotic cell cycle;positive regulation of protein kinase B signaling;regulation of cell adhesion mediated by integrin;regulation of multicellular organism growth;regulation of protein complex assembly;regulation of protein export from nucleus;regulation of type I interferon-mediated signaling pathway;T cell costimulation;triglyceride metabolic process","1-phosphatidylinositol-3-kinase activity;cell adhesion molecule binding;D1 dopamine receptor binding;insulin receptor binding;insulin receptor substrate binding;non-membrane spanning protein tyrosine phosphatase activity;peptide hormone receptor binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;phospholipase binding;phosphoprotein phosphatase activity;protein domain specific binding;protein tyrosine phosphatase activity;receptor tyrosine kinase binding;SH3/SH2 adaptor activity","cytoplasm;cytosol;mitochondrion;nucleoplasm;nucleus;protein complex","Adipocytokine signaling pathway;Axon guidance;Chronic myeloid leukemia;C-type lectin receptor signaling pathway;Epithelial cell signaling in Helicobacter pylori infection;Herpes simplex virus 1 infection;Insulin resistance;Jak-STAT signaling pathway;Leukocyte transendothelial migration;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;Proteoglycans in cancer;Ras signaling pathway;Renal cell carcinoma",null,null,17,17,17,35,35,35,"68.436",0,"85.14",985370000,37,"0.0302751",1,"-0.0570135","-0.095445","sp|Q06124|PTN11_HUMAN;tr|H0YF12|H0YF12_HUMAN","sp|Q06124|PTN11_HUMAN",2108,"Q06124","PTN11_HUMAN","Tyrosine-protein phosphatase non-receptor type 11",null,"PTPN11"]
["18.5209","19.4209","19.3889","18.6713",{"$nulls":3},"5-phosphoribose 1-diphosphate biosynthetic process;hypoxanthine biosynthetic process;nervous system development;nucleoside metabolic process;purine nucleobase metabolic process;purine nucleotide biosynthetic process;pyrimidine nucleotide biosynthetic process;ribonucleoside monophosphate biosynthetic process;urate biosynthetic process","ATP binding;identical protein binding;kinase activity;magnesium ion binding;protein homodimerization activity;ribose phosphate diphosphokinase activity","cytosol","Biosynthesis of amino acids;Carbon metabolism;Metabolic pathways;Pentose phosphate pathway;Purine metabolism",null,null,10,4,4,"36.5","14.8","14.8","34.834","0.00026199","7.3494",65077000,5,"0.0327226",1,"-0.0592279","-0.102912","sp|P60891|PRPS1_HUMAN;tr|B1ALA9|B1ALA9_HUMAN;tr|A0A0B4J207|A0A0B4J207_HUMAN;sp|P21108|PRPS3_HUMAN;tr|B1ALA7|B1ALA7_HUMAN","sp|P60891|PRPS1_HUMAN;tr|B1ALA9|B1ALA9_HUMAN;tr|A0A0B4J207|A0A0B4J207_HUMAN;sp|P21108|PRPS3_HUMAN",1815,"P60891","PRPS1_HUMAN","Ribose-phosphate pyrophosphokinase 1",null,"PRPS1"]
["19.3409","18.8862","19.6487","18.6969",{"$nulls":3},"establishment of endothelial intestinal barrier;negative regulation of cell migration;neutrophil degranulation;positive regulation of protein autophosphorylation;Rap protein signal transduction;regulation of protein tyrosine kinase activity","GDP binding;GTP binding;GTPase activity;transcription coactivator activity","bicellular tight junction;cell-cell contact zone;cytoplasm;cytosol;extracellular exosome;plasma membrane;recycling endosome membrane;tertiary granule membrane","Tight junction",null,null,3,3,3,"16.9","16.9","16.9","20.745","0.00023781","5.3309",53048000,6,"0.0358305",1,"-0.0592546","-0.112346","sp|Q9Y3L5|RAP2C_HUMAN;tr|F6U784|F6U784_HUMAN;sp|P61225|RAP2B_HUMAN;sp|P10114|RAP2A_HUMAN;tr|A0A087X2C3|A0A087X2C3_HUMAN","sp|Q9Y3L5|RAP2C_HUMAN;tr|F6U784|F6U784_HUMAN;sp|P61225|RAP2B_HUMAN;sp|P10114|RAP2A_HUMAN",4994,"Q9Y3L5","RAP2C_HUMAN","Ras-related protein Rap-2c",null,"RAP2C"]
["18.7352","18.784","18.7494","18.889",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;intracellular protein transport;protein glycosylation;protein localization to Golgi apparatus;protein localization to organelle;protein stabilization;retrograde vesicle-mediated transport, Golgi to ER",null,"Golgi apparatus;Golgi membrane;Golgi transport complex;nucleolus;trans-Golgi network membrane",{"$nulls":3},10,10,10,"18.1","18.1","18.1","86.343",0,"23.636",160170000,23,"0.296682",1,"-0.0595779","-0.805598","sp|P83436|COG7_HUMAN","sp|P83436|COG7_HUMAN",2003,"P83436","COG7_HUMAN","Conserved oligomeric Golgi complex subunit 7","OG complex subunit 7","COG7"]
["24.0507","24.3399","24.221","24.2902",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of endopeptidase activity;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex;synapse","Proteasome",null,null,9,9,9,"40.8","40.8","40.8","28.433",0,"99.088",2349700000,95,"0.139925",1,"-0.0602598","-0.405203","sp|P25788|PSA3_HUMAN;tr|G3V4X5|G3V4X5_HUMAN;tr|G3V3W4|G3V3W4_HUMAN;tr|G3V5N4|G3V5N4_HUMAN","sp|P25788|PSA3_HUMAN",1229,"P25788","PSA3_HUMAN","Proteasome subunit alpha type-3",null,"PSMA3"]
["24.4354","24.9734","24.5466","24.9852",{"$nulls":3},"assembly of large subunit precursor of preribosome;gene silencing by miRNA;maturation of 5.8S rRNA;maturation of LSU-rRNA;mature ribosome assembly;miRNA mediated inhibition of translation;positive regulation of translation;regulation of fatty acid biosynthetic process;regulation of glycolytic process;regulation of megakaryocyte differentiation;regulation of reactive oxygen species metabolic process;response to insulin;ribosomal subunit export from nucleus","ribosomal large subunit binding;ribosome binding;translation initiation factor activity","cytoplasm;cytosol;extracellular exosome;nucleolus;nucleoplasm;nucleus;preribosome, large subunit precursor","Ribosome biogenesis in eukaryotes",null,null,6,6,6,"30.2","30.2","30.2","26.599",0,"288.41",2522900000,72,"0.0576519",1,"-0.0614939","-0.177182","sp|P56537|IF6_HUMAN;tr|B7ZBH1|B7ZBH1_HUMAN","sp|P56537|IF6_HUMAN",1783,"P56537","IF6_HUMAN","Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132}","IF-6 {ECO:0000255|HAMAP-Rule:MF_03132}"]
["24.0703","24.2863","24.0453","24.4355",{"$nulls":3},"L-serine biosynthetic process;pyridoxine biosynthetic process","O-phospho-L-serine:2-oxoglutarate aminotransferase activity","cytoplasm;cytosol;extracellular exosome","Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways;Vitamin B6 metabolism",null,null,18,18,18,"57.3","57.3","57.3","40.422",0,"118.17",3729700000,128,"0.0931956",1,"-0.0620775","-0.278366","sp|Q9Y617|SERC_HUMAN","sp|Q9Y617|SERC_HUMAN",5072,"Q9Y617","SERC_HUMAN","Phosphoserine aminotransferase",null,"PSAT1"]
["29.3462","29.0417","29.5568","28.9565",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;canonical glycolysis;cellular response to interferon-gamma;defense response to fungus;gluconeogenesis;killing by host of symbiont cells;killing of cells of other organism;microtubule cytoskeleton organization;negative regulation of endopeptidase activity;negative regulation of translation;neuron apoptotic process;peptidyl-cysteine S-trans-nitrosylation;positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction;positive regulation of cytokine secretion;protein stabilization;regulation of macroautophagy","aspartic-type endopeptidase inhibitor activity;disordered domain specific binding;glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;identical protein binding;microtubule binding;NAD binding;NADP binding;peptidyl-cysteine S-nitrosylase activity","cytoplasm;cytosol;extracellular exosome;extracellular matrix;GAIT complex;intracellular membrane-bounded organelle;intracellular ribonucleoprotein complex;lipid droplet;membrane;microtubule cytoskeleton;nuclear membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;vesicle","Alzheimer disease;Biosynthesis of amino acids;Carbon metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways",null,null,22,22,22,"82.1","82.1","82.1","36.053",0,"323.31",92196000000,1629,"0.0607754",1,"-0.0626869","-0.186277","sp|P04406|G3P_HUMAN;tr|E7EUT5|E7EUT5_HUMAN;sp|O14556|G3PT_HUMAN","sp|P04406|G3P_HUMAN;tr|E7EUT5|E7EUT5_HUMAN",841,"P04406","G3P_HUMAN","Glyceraldehyde-3-phosphate dehydrogenase","APDH","GAPDH"]
["22.5339","22.6523","22.668","22.6447",{"$nulls":3},"activation of innate immune response;B cell lineage commitment;brain development;cell proliferation;cellular protein modification process;cellular response to insulin stimulus;double-strand break repair;double-strand break repair via alternative nonhomologous end joining;double-strand break repair via nonhomologous end joining;ectopic germ cell programmed cell death;heart development;immunoglobulin V(D)J recombination;innate immune response;intrinsic apoptotic signaling pathway in response to DNA damage;negative regulation of apoptotic process;negative regulation of cellular senescence;negative regulation of immunoglobulin production;negative regulation of protein phosphorylation;negative regulation of response to gamma radiation;peptidyl-serine phosphorylation;positive regulation of apoptotic process;positive regulation of developmental growth;positive regulation of fibroblast proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;pro-B cell differentiation;protein destabilization;protein phosphorylation;protein ubiquitination;regulation of circadian rhythm;regulation of smooth muscle cell proliferation;response to activity;response to gamma radiation;rhythmic process;signal transduction involved in mitotic G1 DNA damage checkpoint;somitogenesis;spleen development;T cell differentiation in thymus;T cell lineage commitment;T cell receptor V(D)J recombination;telomere capping;thymus development","ATP binding;DNA-dependent protein kinase activity;double-stranded DNA binding;enzyme binding;protein domain specific binding;protein kinase activity;protein serine/threonine kinase activity;RNA binding;transcription factor binding","cytosol;DNA-dependent protein kinase-DNA ligase 4 complex;extracellular matrix;membrane;nonhomologous end joining complex;nuclear chromosome, telomeric region;nucleolus;nucleoplasm;nucleus;protein complex;protein-DNA complex;transcription factor complex","Cell cycle;Non-homologous end-joining",null,null,199,199,199,"52.1","52.1","52.1","469.08",0,"323.31",51547000000,3003,"0.393024",1,"-0.0632734","-1.04816","sp|P78527|PRKDC_HUMAN;tr|F5GX40|F5GX40_HUMAN;tr|H0YG84|H0YG84_HUMAN","sp|P78527|PRKDC_HUMAN",1980,"P78527","PRKDC_HUMAN","DNA-dependent protein kinase catalytic subunit","NA-PK catalytic subunit;NA-PKcs","PRKDC"]
["26.2352","26.1237","26.1731","26.3136",{"$nulls":5},"membrane;mitochondrion",{"$nulls":3},17,17,17,"67.4","67.4","67.4","33.239",0,"323.31",15485000000,346,"0.259386",1,"-0.0638609","-0.711996","tr|J3KPX7|J3KPX7_HUMAN;sp|Q99623|PHB2_HUMAN;tr|F5GY37|F5GY37_HUMAN;tr|F5GWA7|F5GWA7_HUMAN;tr|F5H3X6|F5H3X6_HUMAN;tr|F5H0C5|F5H0C5_HUMAN;tr|F5H2D2|F5H2D2_HUMAN;tr|U3KPZ5|U3KPZ5_HUMAN","tr|J3KPX7|J3KPX7_HUMAN;sp|Q99623|PHB2_HUMAN;tr|F5GY37|F5GY37_HUMAN;tr|F5GWA7|F5GWA7_HUMAN;tr|F5H3X6|F5H3X6_HUMAN",3868,"J3KPX7","J3KPX7_HUMAN",null,null,"PHB2"]
["21.9312","21.6205","22.0202","21.6594",{"$nulls":3},"cellular response to oxygen-glucose deprivation;cellular response to thapsigargin;dynamin family protein polymerization involved in mitochondrial fission;endocytosis;execution phase of apoptosis;heart contraction;intracellular distribution of mitochondria;membrane fusion;mitochondrial fission;mitochondrial fragmentation involved in apoptotic process;mitochondrial membrane fission;mitochondrion morphogenesis;mitochondrion organization;necroptotic process;negative regulation of mitochondrial fusion;peroxisome fission;positive regulation of apoptotic process;positive regulation of dendritic spine morphogenesis;positive regulation of intrinsic apoptotic signaling pathway;positive regulation of mitochondrial fission;positive regulation of protein secretion;positive regulation of release of cytochrome c from mitochondria;positive regulation of synaptic vesicle endocytosis;positive regulation of synaptic vesicle exocytosis;protein homotetramerization;protein localization to mitochondrion;protein oligomerization;regulation of ATP metabolic process;regulation of autophagy of mitochondrion;regulation of mitochondrion organization;regulation of peroxisome organization;regulation of protein oligomerization;release of cytochrome c from mitochondria;response to flavonoid;response to hypobaric hypoxia;synaptic vesicle recycling via endosome","BH2 domain binding;clathrin binding;GTP binding;GTPase activator activity;GTPase activity;GTP-dependent protein binding;identical protein binding;lipid binding;microtubule binding;protein complex binding;protein homodimerization activity;Rab GTPase binding;ubiquitin protein ligase binding","brush border;cell junction;clathrin-coated pit;cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;Golgi apparatus;Golgi membrane;intracellular membrane-bounded organelle;membrane;microtubule;microtubule cytoskeleton;mitochondrial outer membrane;mitochondrion;perinuclear region of cytoplasm;peroxisome;protein complex;synaptic vesicle membrane","Necroptosis;NOD-like receptor signaling pathway;TNF signaling pathway",null,null,25,25,3,"51.6","51.6","8.2","81.876",0,"323.31",1404000000,88,"0.089668",1,"-0.0639362","-0.268532","sp|O00429|DNM1L_HUMAN;tr|F8VZ52|F8VZ52_HUMAN;tr|B4DPZ9|B4DPZ9_HUMAN;tr|B4DDQ3|B4DDQ3_HUMAN;tr|F8W1W3|F8W1W3_HUMAN;tr|F8VUJ9|F8VUJ9_HUMAN;tr|F8VR28|F8VR28_HUMAN;tr|F8VYL3|F8VYL3_HUMAN;tr|H0YHY4|H0YHY4_HUMAN","sp|O00429|DNM1L_HUMAN",224,"O00429","DNM1L_HUMAN","Dynamin-1-like protein",null,"DNM1L"]
["20.5354","20.7512","20.5236","20.8927",{"$nulls":3},"cellular carbohydrate metabolic process;galactose catabolic process;glycosaminoglycan catabolic process;glycosphingolipid metabolic process;keratan sulfate catabolic process;neutrophil degranulation;response to cortisone;response to Thyroglobulin triiodothyronine","beta-galactosidase activity;exo-alpha-sialidase activity;galactoside binding","azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;Golgi apparatus;intracellular membrane-bounded organelle;lysosomal lumen;perinuclear region of cytoplasm;vacuole","Galactose metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - ganglio series;Lysosome;Metabolic pathways;Other glycan degradation;Sphingolipid metabolism",null,null,8,8,8,"16.5","16.5","16.5","76.074",0,"36.971",367330000,36,"0.10217",1,"-0.0648088","-0.303199","sp|P16278|BGAL_HUMAN;tr|E7EQ29|E7EQ29_HUMAN;tr|C9J539|C9J539_HUMAN;tr|C9J4G9|C9J4G9_HUMAN","sp|P16278|BGAL_HUMAN;tr|E7EQ29|E7EQ29_HUMAN",1077,"P16278","BGAL_HUMAN","Beta-galactosidase",null,"GLB1"]
["22.2297","21.6988","22.38","21.6784",{"$nulls":3},"aspartate transport;ATP biosynthetic process;cellular respiration;gluconeogenesis;L-glutamate transport;malate-aspartate shuttle;mitochondrial transport;response to calcium ion","acidic amino acid transmembrane transporter activity;calcium ion binding;L-aspartate transmembrane transporter activity;L-glutamate transmembrane transporter activity;transporter activity","integral component of membrane;integral component of plasma membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},21,21,17,"42.4","42.4","36.7","74.175",0,"136.19",2290000000,188,"0.0476358",1,"-0.0649872","-0.147713","sp|Q9UJS0|CMC2_HUMAN;tr|R4GN64|R4GN64_HUMAN","sp|Q9UJS0|CMC2_HUMAN",4768,"Q9UJS0","CMC2_HUMAN","Calcium-binding mitochondrial carrier protein Aralar2",null,"SLC25A13"]
["14.8015","16.407","15.9035","15.4372",{"$nulls":3},"DNA replication;intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;nuclear pore complex assembly;nuclear pore organization;nucleocytoplasmic transport;positive regulation of mRNA splicing, via spliceosome;posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery;protein import into nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;RNA export from nucleus;sister chromatid cohesion;telomere tethering at nuclear periphery;tRNA export from nucleus;viral process;viral transcription","mRNA binding;nuclear localization sequence binding;nucleocytoplasmic transporter activity;promoter-specific chromatin binding;RNA binding;RNA polymerase II transcription coactivator activity;serine-type peptidase activity;structural constituent of nuclear pore;transporter activity","cytosol;host cell;intracellular membrane-bounded organelle;intracellular ribonucleoprotein complex;nuclear body;nuclear envelope;nuclear inclusion body;nuclear membrane;nuclear periphery;nuclear pore;nuclear pore cytoplasmic filaments;nuclear pore nuclear basket;nuclear pore outer ring;nucleoplasm","Influenza A;RNA transport",null,null,4,4,4,"2.9","2.9","2.9","197.58","0.00066905","4.1269",58726000,11,"0.024946",1,"-0.0660944","-0.079067","sp|P52948|NUP98_HUMAN;tr|H0YEN4|H0YEN4_HUMAN;tr|H7C3P6|H7C3P6_HUMAN","sp|P52948|NUP98_HUMAN",1703,"P52948","NUP98_HUMAN","Nuclear pore complex protein Nup98-Nup96",null,"NUP98"]
["23.438","23.541","23.6479","23.464",{"$nulls":3},"cellular response to amino acid stimulus;negative regulation of cyclin-dependent protein serine/threonine kinase activity;NLS-bearing protein import into nucleus;positive regulation of protein import into nucleus;protein import into nucleus, translocation;ribosomal protein import into nucleus;viral process","GTPase inhibitor activity;nuclear localization sequence binding;protein transporter activity;Ran GTPase binding;RNA binding","cytoplasm;membrane;nuclear membrane;nuclear periphery;nuclear pore;nucleolus;nucleus",{"$nulls":3},33,33,27,"47.8","47.8","40.6","123.63",0,"323.31",6317100000,311,"0.227242",1,"-0.0664873","-0.630888","sp|O00410|IPO5_HUMAN;tr|H0Y8C6|H0Y8C6_HUMAN;tr|E7ETV3|E7ETV3_HUMAN;tr|E7EQT5|E7EQT5_HUMAN;tr|C9JZD8|C9JZD8_HUMAN;tr|C9JMV5|C9JMV5_HUMAN;tr|E7EWK4|E7EWK4_HUMAN;tr|E7EX05|E7EX05_HUMAN;tr|E7EV12|E7EV12_HUMAN;tr|C9JQT6|C9JQT6_HUMAN;tr|E7ESA1|E7ESA1_HUMAN;tr|E7ESZ1|E7ESZ1_HUMAN;tr|E7ETV8|E7ETV8_HUMAN;tr|C9J875|C9J875_HUMAN;tr|C9JZ53|C9JZ53_HUMAN;tr|C9JXE0|C9JXE0_HUMAN","sp|O00410|IPO5_HUMAN;tr|H0Y8C6|H0Y8C6_HUMAN",220,"O00410","IPO5_HUMAN","Importin-5","mp5","IPO5"]
["22.4598","22.6955","23.0164","22.2734",{"$nulls":3},"bicellular tight junction assembly;lipopolysaccharide-mediated signaling pathway;negative regulation of apoptotic process;negative regulation of transcription from RNA polymerase II promoter;positive regulation of angiogenesis;positive regulation of autophagy;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of protein kinase B signaling","double-stranded RNA binding;NF-kappaB binding;RNA binding;RNA polymerase II transcription factor binding;transcription coactivator activity","apical plasma membrane;bicellular tight junction;cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;fibrillar center;integral component of membrane;intercellular canaliculus;nuclear body;nuclear membrane;nucleus;perinuclear region of cytoplasm",{"$nulls":3},31,31,31,68,68,68,"63.836",0,"323.31",18823000000,748,"0.0560621",1,"-0.0672455","-0.172536","sp|Q86UE4|LYRIC_HUMAN;tr|E5RJU9|E5RJU9_HUMAN;tr|H0YB56|H0YB56_HUMAN;tr|H0YBJ8|H0YBJ8_HUMAN;tr|H0YBE0|H0YBE0_HUMAN","sp|Q86UE4|LYRIC_HUMAN;tr|E5RJU9|E5RJU9_HUMAN",3047,"Q86UE4","LYRIC_HUMAN","Protein LYRIC",null,"MTDH"]
["18.7921","17.925","19.1473","17.7061",{"$nulls":3},"glutathione biosynthetic process;glutathione metabolic process","5-oxoprolinase (ATP-hydrolyzing) activity;ATP binding","cytosol","Glutathione metabolism;Metabolic pathways",null,null,8,8,8,"9.3","9.3","9.3","137.46",0,"30.898",151670000,27,"0.0255738",1,"-0.0681229","-0.0810053","sp|O14841|OPLA_HUMAN;tr|A0A087WY99|A0A087WY99_HUMAN","sp|O14841|OPLA_HUMAN",292,"O14841","OPLA_HUMAN","5-oxoprolinase",null,"OPLAH"]
["20.7976","17.6646","19.5189","19.0816",{"$nulls":3},"regulation of phosphorylation of RNA polymerase II C-terminal domain","peptidyl-prolyl cis-trans isomerase activity;RNA binding","cytosol;nucleoplasm",{"$nulls":3},6,6,6,"17.3","17.3","17.3","57.224",0,"21.441",249820000,11,"0.0136337",1,"-0.0691633","-0.0437274","sp|Q8WUA2|PPIL4_HUMAN","sp|Q8WUA2|PPIL4_HUMAN",3415,"Q8WUA2","PPIL4_HUMAN","Peptidyl-prolyl cis-trans isomerase-like 4","PIase","PPIL4"]
["18.2514","20.1875","19.0778","19.5009",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;signal transduction;translation","GTP binding;GTPase activity;translation elongation factor activity","cytosol;extracellular exosome;intracellular;membrane","Legionellosis;mRNA surveillance pathway",null,null,10,10,10,"24.1","24.1","24.1","75.472",0,"42.725",372540000,69,"0.0221905",1,"-0.069891","-0.0705325","sp|Q9Y450|HBS1L_HUMAN;tr|B7Z524|B7Z524_HUMAN;tr|H0YDX7|H0YDX7_HUMAN;tr|J3QT46|J3QT46_HUMAN;tr|H0YES5|H0YES5_HUMAN;tr|E9PHZ9|E9PHZ9_HUMAN;tr|E9PS53|E9PS53_HUMAN;tr|E9PN23|E9PN23_HUMAN;tr|G5E991|G5E991_HUMAN;tr|E9PMN1|E9PMN1_HUMAN;tr|E9PLR4|E9PLR4_HUMAN","sp|Q9Y450|HBS1L_HUMAN;tr|B7Z524|B7Z524_HUMAN;tr|H0YDX7|H0YDX7_HUMAN;tr|J3QT46|J3QT46_HUMAN",5005,"Q9Y450","HBS1L_HUMAN","HBS1-like protein",null,"HBS1L"]
["21.1539","21.296","21.1833","21.4069",{"$nulls":4},"cytochrome-c oxidase activity","mitochondrial respiratory chain;mitochondrion;nucleolus",{"$nulls":3},3,3,3,"58.2","58.2","58.2","8.8399",0,"8.939",98749000,12,"0.187326",1,"-0.070075","-0.529011","tr|E5RJZ1|E5RJZ1_HUMAN;tr|H0YBD2|H0YBD2_HUMAN;sp|O14548|COX7R_HUMAN","tr|E5RJZ1|E5RJZ1_HUMAN;tr|H0YBD2|H0YBD2_HUMAN;sp|O14548|COX7R_HUMAN",259,"E5RJZ1","E5RJZ1_HUMAN",null,null,"COX7A2L"]
["19.3287",1,"19.4711",1,{"$nulls":9},1,1,1,35,35,35,"4.53",0,"11.53",17053000,6,"0.00168365",1,"-0.0711946","-0.00547198","tr|K7ESH8|K7ESH8_HUMAN;tr|K7EQV2|K7EQV2_HUMAN;tr|K7ERD7|K7ERD7_HUMAN;sp|O95707|RPP29_HUMAN","tr|K7ESH8|K7ESH8_HUMAN;tr|K7EQV2|K7EQV2_HUMAN;tr|K7ERD7|K7ERD7_HUMAN;sp|O95707|RPP29_HUMAN",754,"K7ESH8","K7ESH8_HUMAN",null,null,"POP4"]
["21.7073","21.0397","21.8965","20.9942",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","mRNA binding;RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome","Ribosome",null,null,7,7,7,"44.9","44.9","44.9","20.692",0,"18.399",359880000,29,"0.0410175",1,"-0.0718203","-0.127975","sp|Q9BYD1|RM13_HUMAN;tr|E5RJI7|E5RJI7_HUMAN;tr|H0YAX3|H0YAX3_HUMAN;tr|E5RFI2|E5RFI2_HUMAN","sp|Q9BYD1|RM13_HUMAN;tr|E5RJI7|E5RJI7_HUMAN",4059,"Q9BYD1","RM13_HUMAN","39S ribosomal protein L13, mitochondrial","13mt;RP-L13","MRPL13"]
["19.0767","17.9453","19.1626","18.0051",{"$nulls":3},"rRNA processing","RNA binding","cytosol;nucleolus;nucleoplasm;nucleus",{"$nulls":3},7,7,7,"29.8","29.8","29.8","27.924",0,"43.987",535260000,37,"0.0285135",1,"-0.0728731","-0.0900493","sp|Q9NRX1|PNO1_HUMAN;tr|F8WBJ6|F8WBJ6_HUMAN","sp|Q9NRX1|PNO1_HUMAN;tr|F8WBJ6|F8WBJ6_HUMAN",4427,"Q9NRX1","PNO1_HUMAN","RNA-binding protein PNO1",null,"PNO1"]
[1,"17.0161",1,"17.1637",{"$nulls":3},"plasma membrane tubulation",null,"cytosol;plasma membrane",{"$nulls":3},2,2,2,"7.4","7.4","7.4","46.494","0.00025394","6.6955",12846000,2,"0.00199682",1,"-0.0738106","-0.00648748","tr|A0A0C4DGG1|A0A0C4DGG1_HUMAN;sp|Q9UKS6|PACN3_HUMAN;tr|H0YDM6|H0YDM6_HUMAN","tr|A0A0C4DGG1|A0A0C4DGG1_HUMAN;sp|Q9UKS6|PACN3_HUMAN;tr|H0YDM6|H0YDM6_HUMAN",4792,"A0A0C4DGG1","A0A0C4DGG1_HUMAN",null,null,"PACSIN3"]
["17.419","17.2473","17.525","17.2901",{"$nulls":3},"protein monoubiquitination;protein ubiquitination;rescue of stalled ribosome","metal ion binding;ribosome binding;RNA binding;ubiquitin protein ligase activity",{"$nulls":4},6,6,6,"8.8","8.8","8.8","98.636",0,"17.324",80106000,16,"0.180502",1,"-0.0744162","-0.511412","sp|Q86UK7|ZN598_HUMAN;tr|H3BQQ2|H3BQQ2_HUMAN;tr|H3BR87|H3BR87_HUMAN","sp|Q86UK7|ZN598_HUMAN;tr|H3BQQ2|H3BQQ2_HUMAN",3048,"Q86UK7","ZN598_HUMAN","E3 ubiquitin-protein ligase ZNF598 {ECO:0000305}",null,"ZNF598"]
["21.6227","22.7167","21.8624","22.626",{"$nulls":3},"mitochondrial ATP synthesis coupled electron transport;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;respiratory gaseous exchange;response to oxidative stress","electron transfer activity;NADH dehydrogenase (ubiquinone) activity","cytosol;mitochondrial inner membrane;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,5,5,5,"46.2","46.2","46.2","17.114",0,"48.433",349440000,29,"0.0356269",1,"-0.0745344","-0.11173","sp|Q9UI09|NDUAC_HUMAN;tr|H0YID5|H0YID5_HUMAN;tr|F8VRD8|F8VRD8_HUMAN;tr|H0YIT1|H0YIT1_HUMAN;tr|F8VXI1|F8VXI1_HUMAN","sp|Q9UI09|NDUAC_HUMAN",4743,"Q9UI09","NDUAC_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12",null,"NDUFA12"]
["21.7401","21.0964","22.3","20.6893",{"$nulls":9},5,5,5,"45.4","45.4","45.4","15.296",0,"15.003",159380000,12,"0.0278829",1,"-0.0764208","-0.0881137","tr|C9JQ41|C9JQ41_HUMAN;tr|H7C525|H7C525_HUMAN;sp|Q4VC31|CCD58_HUMAN;tr|C9JBU9|C9JBU9_HUMAN","tr|C9JQ41|C9JQ41_HUMAN;tr|H7C525|H7C525_HUMAN;sp|Q4VC31|CCD58_HUMAN",2637,"C9JQ41","C9JQ41_HUMAN",null,null,"CCDC58"]
["21.6903","21.0422","21.6447","21.2417",{"$nulls":3},"cleavage involved in rRNA processing;maturation of LSU-rRNA;mitochondrial translational elongation;mitochondrial translational termination;rRNA pseudouridine synthesis;snRNA pseudouridine synthesis;translation","box H/ACA snoRNA binding;RNA binding;structural constituent of ribosome","box H/ACA snoRNP complex;large ribosomal subunit;mitochondrial inner membrane;mitochondrion","Ribosome",null,null,7,7,7,"27.1","27.1","27.1","36.908",0,"51.57",383450000,24,"0.0660549",1,"-0.0769157","-0.201555","sp|Q9BYD6|RM01_HUMAN;tr|H0Y8N7|H0Y8N7_HUMAN","sp|Q9BYD6|RM01_HUMAN;tr|H0Y8N7|H0Y8N7_HUMAN",4062,"Q9BYD6","RM01_HUMAN","39S ribosomal protein L1, mitochondrial","1mt;RP-L1","MRPL1"]
["22.2126","21.9304","22.468","21.8298",{"$nulls":3},"fatty acid beta-oxidation","dodecenoyl-CoA delta-isomerase activity;enoyl-CoA hydratase activity;intramolecular oxidoreductase activity","extracellular exosome;mitochondrial inner membrane;mitochondrial matrix;mitochondrion","Fatty acid degradation",null,null,8,8,8,"30.5","30.5","30.5","32.816",0,"23.091",531030000,25,"0.073113",1,"-0.0773897","-0.221798","sp|P42126|ECI1_HUMAN;tr|Q96DC0|Q96DC0_HUMAN;tr|H3BS70|H3BS70_HUMAN","sp|P42126|ECI1_HUMAN;tr|Q96DC0|Q96DC0_HUMAN;tr|H3BS70|H3BS70_HUMAN",1463,"P42126","ECI1_HUMAN","Enoyl-CoA delta isomerase 1, mitochondrial",null,"ECI1"]
["18.8222","16.2342","18.3709","16.8432",{"$nulls":3},"acetyl-CoA biosynthetic process;acyl-CoA metabolic process;fatty acid biosynthetic process;fatty acid oxidation;malonyl-CoA catabolic process;positive regulation of fatty acid oxidation;regulation of fatty acid beta-oxidation;regulation of glucose metabolic process;response to ischemia","identical protein binding;malonyl-CoA decarboxylase activity;receptor binding","cytoplasm;cytosol;mitochondrial matrix;mitochondrion;peroxisomal matrix;peroxisome","AMPK signaling pathway;beta-Alanine metabolism;Metabolic pathways;Peroxisome;Propanoate metabolism",null,null,4,4,4,"10.8","10.8","10.8","55.003",0,"8.1698",64944000,13,"0.0164055",1,"-0.0788326","-0.0524615","sp|O95822|DCMC_HUMAN;tr|V9GYW3|V9GYW3_HUMAN;tr|V9GY18|V9GY18_HUMAN;tr|A0A087X1B8|A0A087X1B8_HUMAN","sp|O95822|DCMC_HUMAN",769,"O95822","DCMC_HUMAN","Malonyl-CoA decarboxylase, mitochondrial","CD","MLYCD"]
["23.1626","22.9861","23.5046","22.8044",{"$nulls":3},"astrocyte cell migration;cellular calcium ion homeostasis;cellular protein metabolic process;chondroitin sulfate catabolic process;ganglioside catabolic process;glycosphingolipid metabolic process;hyaluronan catabolic process;keratan sulfate catabolic process;lipid storage;locomotory behavior;lysosome organization;male courtship behavior;myelination;neuromuscular process controlling balance;neutrophil degranulation;oligosaccharide catabolic process;oogenesis;penetration of zona pellucida;phospholipid biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;regulation of cell shape;sensory perception of sound;skeletal system development","acetylglucosaminyltransferase activity;beta-N-acetylhexosaminidase activity;N-acetyl-beta-D-galactosaminidase activity;protein heterodimerization activity;protein homodimerization activity","acrosomal vesicle;azurophil granule;azurophil granule lumen;extracellular exosome;extracellular region;lysosomal lumen;membrane","Amino sugar and nucleotide sugar metabolism;Glycosaminoglycan degradation;Glycosphingolipid biosynthesis - ganglio series;Glycosphingolipid biosynthesis - globo and isoglobo series;Lysosome;Metabolic pathways;Other glycan degradation",null,null,16,16,16,"39.4","39.4","39.4","63.111",0,"94.239",2236600000,82,"0.073177",1,"-0.0801468","-0.221981","sp|P07686|HEXB_HUMAN;tr|Q5URX0|Q5URX0_HUMAN;tr|H0YA83|H0YA83_HUMAN;tr|H0Y9B6|H0Y9B6_HUMAN;tr|D6REQ8|D6REQ8_HUMAN;tr|H0Y9M3|H0Y9M3_HUMAN","sp|P07686|HEXB_HUMAN;tr|Q5URX0|Q5URX0_HUMAN;tr|H0YA83|H0YA83_HUMAN;tr|H0Y9B6|H0Y9B6_HUMAN",901,"P07686","HEXB_HUMAN","Beta-hexosaminidase subunit beta",null,"HEXB"]
["18.2942",1,"18.4568",1,{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"10.8","10.8","10.8","20.798","0.0099617","2.1808",13585000,4,"0.00203686",1,"-0.0813026","-0.00661725","tr|K7EKW3|K7EKW3_HUMAN;tr|E7ESS3|E7ESS3_HUMAN;sp|Q71RG4|TMUB2_HUMAN","tr|K7EKW3|K7EKW3_HUMAN;tr|E7ESS3|E7ESS3_HUMAN;sp|Q71RG4|TMUB2_HUMAN",2952,"K7EKW3","K7EKW3_HUMAN",null,null,"TMUB2"]
["19.0242",1,"19.1884",1,{"$nulls":3},"regulation of transcription, DNA-templated","sequence-specific DNA binding","nucleus",{"$nulls":3},1,1,1,"7.8","7.8","7.8","17.418",0,"8.261",76793000,4,"0.00197399",1,"-0.0821133","-0.00641348","tr|A0A087WTJ6|A0A087WTJ6_HUMAN;sp|P47902|CDX1_HUMAN","tr|A0A087WTJ6|A0A087WTJ6_HUMAN;sp|P47902|CDX1_HUMAN",1531,"A0A087WTJ6","A0A087WTJ6_HUMAN",null,null,"CDX1"]
["22.2053","22.9408","22.8995","22.4109",{"$nulls":3},"in utero embryonic development;nucleotide-excision repair, DNA damage recognition;post-translational protein modification;protein deneddylation;response to light stimulus;signal transduction;transcription-coupled nucleotide-excision repair;ubiquitin-dependent protein catabolic process",null,"COP9 signalosome;cytoplasm;cytosol;nucleoplasm;nucleus",{"$nulls":3},8,8,8,27,27,27,"47.873",0,"130.76",1454300000,52,"0.060708",1,"-0.0821629","-0.186082","sp|Q9UNS2|CSN3_HUMAN;tr|H7C3P9|H7C3P9_HUMAN;tr|C9JLV5|C9JLV5_HUMAN;tr|J3QL22|J3QL22_HUMAN;tr|J3QS85|J3QS85_HUMAN;tr|J3KTQ1|J3KTQ1_HUMAN;tr|J3QKR0|J3QKR0_HUMAN;tr|K7ES36|K7ES36_HUMAN","sp|Q9UNS2|CSN3_HUMAN;tr|H7C3P9|H7C3P9_HUMAN",4854,"Q9UNS2","CSN3_HUMAN","COP9 signalosome complex subunit 3","GN3;ignalosome subunit 3","COPS3"]
["24.2001","24.3861","24.4361","24.3155",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;aggresome assembly;ATP metabolic process;autophagosome maturation;autophagy;cellular response to DNA damage stimulus;DNA repair;double-strand break repair;endoplasmic reticulum stress-induced pre-emptive quality control;endoplasmic reticulum unfolded protein response;endosome to lysosome transport via multivesicular body sorting pathway;ER to Golgi vesicle-mediated transport;ERAD pathway;ER-associated misfolded protein catabolic process;error-free translesion synthesis;establishment of protein localization;flavin adenine dinucleotide catabolic process;macroautophagy;NADH metabolic process;neutrophil degranulation;positive regulation of ATP biosynthetic process;positive regulation of Lys63-specific deubiquitinase activity;positive regulation of mitochondrial membrane potential;positive regulation of oxidative phosphorylation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein catabolic process;positive regulation of protein complex assembly;positive regulation of protein K63-linked deubiquitination;proteasomal protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein folding;protein hexamerization;protein homooligomerization;protein methylation;protein N-linked glycosylation via asparagine;protein ubiquitination;regulation of aerobic respiration;regulation of apoptotic process;retrograde protein transport, ER to cytosol;translesion synthesis;transmembrane transport;ubiquitin-dependent ERAD pathway;viral genome replication","ADP binding;ATP binding;ATPase activity;BAT3 complex binding;deubiquitinase activator activity;identical protein binding;K48-linked polyubiquitin modification-dependent protein binding;lipid binding;MHC class I protein binding;polyubiquitin modification-dependent protein binding;protein domain specific binding;protein phosphatase binding;RNA binding;ubiquitin protein ligase binding;ubiquitin-like protein ligase binding;ubiquitin-specific protease binding","ATPase complex;azurophil granule lumen;cytoplasm;cytosol;Derlin-1 retrotranslocation complex;endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular membrane-bounded organelle;lipid droplet;myelin sheath;nucleoplasm;nucleus;perinuclear region of cytoplasm;proteasome complex;protein complex;secretory granule lumen;site of double-strand break;VCP-NPL4-UFD1 AAA ATPase complex;VCP-NSFL1C complex","Legionellosis;Protein processing in endoplasmic reticulum",null,null,49,49,49,"71.6","71.6","71.6","89.321",0,"323.31",8096000000,358,"0.272961",1,"-0.0826979","-0.7461","sp|P55072|TERA_HUMAN;tr|C9IZA5|C9IZA5_HUMAN;tr|C9JUP7|C9JUP7_HUMAN","sp|P55072|TERA_HUMAN",1753,"P55072","TERA_HUMAN","Transitional endoplasmic reticulum ATPase","ER ATPase","VCP"]
["22.8024","22.1974","23.0895","22.0768",{"$nulls":3},"autophagy;cell proliferation;cellular calcium ion homeostasis;cellular water homeostasis;epithelial cell differentiation;hemostasis;membrane fusion;negative regulation of gene expression;regulation of cell shape;response to calcium ion;response to organic cyclic compound;response to salt stress;social behavior","calcium ion binding;calcium-dependent phospholipid binding;calcium-dependent protein binding;integrin binding;RNA binding","cytosol;endoplasmic reticulum membrane;extracellular exosome;membrane;nuclear envelope;nucleus;plasma membrane",{"$nulls":3},10,10,10,"21.1","21.1","21.1","52.739",0,"82.151",1200300000,72,"0.0454344",1,"-0.083271","-0.141172","sp|P20073|ANXA7_HUMAN","sp|P20073|ANXA7_HUMAN",1143,"P20073","ANXA7_HUMAN","Annexin A7",null,"ANXA7"]
["20.9523","20.8035","20.4263","21.4973",{"$nulls":3},"microtubule-based process","GTP binding;GTPase activity;structural constituent of cytoskeleton","cytoplasm;extracellular exosome;extracellular vesicle;microtubule;microtubule cytoskeleton;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,21,2,2,"51.2","6.1","6.1","49.906","0.00024594","5.9645",314070000,66,"0.050192",1,"-0.0839481","-0.155279","sp|Q13885|TBB2A_HUMAN;sp|Q9BVA1|TBB2B_HUMAN;tr|I3L2F9|I3L2F9_HUMAN;sp|A6NNZ2|TBB8L_HUMAN;sp|Q9H4B7|TBB1_HUMAN;CON__ENSEMBL:ENSBTAP00000025008;tr|M0R1I1|M0R1I1_HUMAN","sp|Q13885|TBB2A_HUMAN;sp|Q9BVA1|TBB2B_HUMAN",2312,"Q13885","TBB2A_HUMAN","Tubulin beta-2A chain",null,"TUBB2A"]
["24.2463","24.2546","24.3748","24.2948",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of protein targeting to mitochondrion;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex;secretory granule lumen","Proteasome",null,null,9,9,9,"43.3","43.3","43.3","29.965",0,"61.961",1929300000,67,"0.767279",1,"-0.0843687","-2.09723","sp|Q99436|PSB7_HUMAN;tr|Q5TBG5|Q5TBG5_HUMAN","sp|Q99436|PSB7_HUMAN",3841,"Q99436","PSB7_HUMAN","Proteasome subunit beta type-7",null,"PSMB7"]
["21.5961","21.1226","21.5821","21.3074",{"$nulls":3},"adenosine salvage;AMP salvage;dATP biosynthetic process;purine-containing compound salvage;ribonucleoside monophosphate biosynthetic process","adenosine kinase activity;ATP binding;metal ion binding;RNA binding","cytosol;nucleoplasm;nucleus","Metabolic pathways;Purine metabolism",null,null,14,14,14,55,55,55,"40.545",0,"84.304",523870000,43,"0.105431",1,"-0.0854464","-0.312161","sp|P55263|ADK_HUMAN","sp|P55263|ADK_HUMAN",1764,"P55263","ADK_HUMAN","Adenosine kinase","K","ADK"]
["25.5621","24.6662","25.4437","24.9569",{"$nulls":3},"histone H3-K27 trimethylation;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;nucleosome assembly;nucleosome positioning","chromatin DNA binding;RNA binding","nuclear euchromatin;nucleosome;nucleus;transcriptionally active chromatin",{"$nulls":3},8,8,2,"32.4","32.4","11.7","21.364",0,"49.777",45075000000,314,"0.0548494",1,"-0.0861521","-0.168984","sp|P16403|H12_HUMAN","sp|P16403|H12_HUMAN",1081,"P16403","H12_HUMAN","Histone H1.2",null,"HIST1H1C"]
["23.2593","22.9613","23.494","22.8989",{"$nulls":3},"translational initiation;viral translational termination-reinitiation","RNA binding;translation initiation factor activity","cytosol;eukaryotic translation initiation factor 3 complex;fibrillar center;membrane;nucleoplasm",{"$nulls":3},23,23,23,"41.1","41.1","41.1","66.726",0,241,2514900000,153,"0.0862412",1,"-0.0861597","-0.25894","sp|Q9Y262|EIF3L_HUMAN;tr|B0QY89|B0QY89_HUMAN;tr|B0QY90|B0QY90_HUMAN;tr|C9JHP4|C9JHP4_HUMAN;tr|C9K0Q7|C9K0Q7_HUMAN;tr|H7C3A0|H7C3A0_HUMAN;tr|H0Y7E6|H0Y7E6_HUMAN","sp|Q9Y262|EIF3L_HUMAN;tr|B0QY89|B0QY89_HUMAN;tr|B0QY90|B0QY90_HUMAN",4895,"Q9Y262","EIF3L_HUMAN","Eukaryotic translation initiation factor 3 subunit L {ECO:0000255|HAMAP-Rule:MF_03011}","IF3l {ECO:0000255|HAMAP-Rule:MF_03011}","EIF3L"]
["15.4431",1,"15.6188",1,{"$nulls":3},"calcium ion export;calcium ion import across plasma membrane;calcium ion transmembrane import into cytosol;calcium ion transmembrane transport;cellular calcium ion homeostasis;cellular response to epinephrine stimulus;flagellated sperm motility;hippocampus development;ion transmembrane transport;negative regulation of adrenergic receptor signaling pathway involved in heart process;negative regulation of arginine catabolic process;negative regulation of calcineurin-NFAT signaling cascade;negative regulation of cardiac muscle hypertrophy in response to stress;negative regulation of citrulline biosynthetic process;negative regulation of nitric oxide biosynthetic process;negative regulation of nitric oxide mediated signal transduction;negative regulation of nitric-oxide synthase activity;negative regulation of peptidyl-cysteine S-nitrosylation;negative regulation of the force of heart contraction;neural retina development;positive regulation of cAMP-dependent protein kinase activity;positive regulation of peptidyl-serine phosphorylation;regulation of cardiac conduction;regulation of cell cycle G1/S phase transition;regulation of sodium ion transmembrane transport;regulation of transcription from RNA polymerase II promoter;response to hydrostatic pressure;spermatogenesis","ATP binding;calcium-transporting ATPase activity;calmodulin binding;metal ion binding;nitric-oxide synthase binding;nitric-oxide synthase inhibitor activity;PDZ domain binding;protein kinase binding;protein phosphatase 2B binding;scaffold protein binding","basolateral plasma membrane;caveola;integral component of plasma membrane;intracellular membrane-bounded organelle;membrane;neuron projection;plasma membrane;protein complex;sperm flagellum;sperm principal piece;T-tubule;Z disc","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Calcium signaling pathway;cAMP signaling pathway;cGMP-PKG signaling pathway;Pancreatic secretion;Salivary secretion",null,null,6,1,1,"7.5","1.3","1.3","137.92","0.0065411","2.5704",11983000,1,"0.00263358",1,"-0.087853","-0.00855004","sp|P23634|AT2B4_HUMAN","sp|P23634|AT2B4_HUMAN",1206,"P23634","AT2B4_HUMAN","Plasma membrane calcium-transporting ATPase 4 {ECO:0000305}","MCA4 {ECO:0000303|PubMed:1531651, ECO:0000312|EMBL:AAA50819.1}","ATP2B4"]
["18.95","18.486","18.9291","18.6847",{"$nulls":3},"N-terminal peptidyl-methionine acetylation",null,"cytosol;Golgi apparatus;NatB complex",{"$nulls":3},11,11,11,"11.3","11.3","11.3","112.29",0,"46.596",190400000,21,"0.115194",1,"-0.0888348","-0.338808","sp|Q14CX7|NAA25_HUMAN","sp|Q14CX7|NAA25_HUMAN",2415,"Q14CX7","NAA25_HUMAN","N-alpha-acetyltransferase 25, NatB auxiliary subunit",null,"NAA25"]
["18.3588","19.4065","18.6857","19.26",{"$nulls":3},"fatty acid metabolic process;glucuronate catabolic process to xylulose 5-phosphate","3-hydroxyacyl-CoA dehydrogenase activity;L-gulonate 3-dehydrogenase activity;NAD+ binding;protein homodimerization activity","cytosol;extracellular exosome","Metabolic pathways;Pentose and glucuronate interconversions",null,null,4,4,4,"12.9","12.9","12.9","35.419",0,"8.1369",59523000,6,"0.0487368",1,"-0.0901957","-0.150976","sp|Q9Y2S2|CRYL1_HUMAN;tr|A0A087WW38|A0A087WW38_HUMAN","sp|Q9Y2S2|CRYL1_HUMAN;tr|A0A087WW38|A0A087WW38_HUMAN",4933,"Q9Y2S2","CRYL1_HUMAN","Lambda-crystallin homolog",null,"CRYL1"]
["24.0335","23.1591","24.0608","23.3131",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;neutrophil degranulation;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein K63-linked deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of proteasomal protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to ethanol;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;ubiquitin-dependent protein catabolic process;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activator activity;Lys63-specific deubiquitinase activity;metal ion binding;metallopeptidase activity;proteasome binding;thiol-dependent ubiquitinyl hydrolase activity","cytosol;cytosolic proteasome complex;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleoplasm;nucleus;proteasome accessory complex;proteasome complex;proteasome regulatory particle, lid subcomplex;secretory granule lumen","Epstein-Barr virus infection;Proteasome",null,null,10,10,10,50,50,50,"34.577",0,"117.14",1720000000,64,"0.0509941",1,"-0.090683","-0.157647","sp|O00487|PSDE_HUMAN;tr|C9JW37|C9JW37_HUMAN","sp|O00487|PSDE_HUMAN",234,"O00487","PSDE_HUMAN","26S proteasome non-ATPase regulatory subunit 14",null,"PSMD14"]
["20.4387","21.081","20.5751","21.1282",{"$nulls":3},"regulation of cytoplasmic mRNA processing body assembly;stress granule assembly","cadherin binding;RNA binding","cytoplasmic stress granule;cytosol;membrane;nuclear speck",{"$nulls":3},17,17,17,"21.9","21.9","21.9","113.37",0,"56.817",660380000,91,"0.0713061",1,"-0.0918112","-0.216635","sp|Q8WWM7|ATX2L_HUMAN;tr|H3BUF6|H3BUF6_HUMAN;tr|H3BSK9|H3BSK9_HUMAN;tr|H3BUE3|H3BUE3_HUMAN;tr|H3BSQ5|H3BSQ5_HUMAN;tr|H3BRB0|H3BRB0_HUMAN;tr|A0A0C4DGL7|A0A0C4DGL7_HUMAN","sp|Q8WWM7|ATX2L_HUMAN;tr|H3BUF6|H3BUF6_HUMAN",3456,"Q8WWM7","ATX2L_HUMAN","Ataxin-2-like protein",null,"ATXN2L"]
["20.8909","21.1007","21.0644","21.1123",{"$nulls":3},"'de novo' posttranslational protein folding;endoplasmic reticulum mannose trimming;endoplasmic reticulum unfolded protein response;ER-associated misfolded protein catabolic process;protein N-linked glycosylation via asparagine","UDP-glucose:glycoprotein glucosyltransferase activity;unfolded protein binding","endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum quality control compartment;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;protein complex","Protein processing in endoplasmic reticulum",null,null,35,35,34,33,33,"32.5","177.19",0,"203.85",1453900000,115,"0.318577",1,"-0.0925722","-0.860491","sp|Q9NYU2|UGGG1_HUMAN;tr|H7BZG0|H7BZG0_HUMAN;tr|F8WCI2|F8WCI2_HUMAN;tr|F8WCE6|F8WCE6_HUMAN","sp|Q9NYU2|UGGG1_HUMAN",4575,"Q9NYU2","UGGG1_HUMAN","UDP-glucose:glycoprotein glucosyltransferase 1","GT1;UGT1","UGGT1"]
["18.5599","18.8227","19.1843","18.3844",{"$nulls":3},"adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;cellular response to organic substance;epithelial cell differentiation involved in prostate gland development;ganglioside GM1 transport to membrane;glycosphingolipid metabolic process;lipid transport;negative regulation of hydrogen peroxide-induced cell death;neutrophil degranulation;platelet degranulation;positive regulation of MAPK cascade;prostate gland growth;regulation of autophagy;regulation of lipid metabolic process","beta-galactosidase activity;enzyme activator activity;ganglioside GM1 binding;ganglioside GM2 binding;ganglioside GM3 binding;ganglioside GP1c binding;ganglioside GT1b binding;G-protein coupled receptor binding;identical protein binding;lipid binding;phospholipid binding;protein homodimerization activity","azurophil granule membrane;extracellular exosome;extracellular matrix;extracellular region;extracellular space;integral component of membrane;intracellular membrane-bounded organelle;lysosomal lumen;lysosomal membrane;lysosome;mitochondrion;plasma membrane","Lysosome",null,null,6,6,6,"16.8","16.8","16.8","58.112",0,"12.204",102420000,12,"0.0728381",1,"-0.093051","-0.221014","sp|P07602|SAP_HUMAN;tr|C9JIZ6|C9JIZ6_HUMAN;tr|Q5BJH1|Q5BJH1_HUMAN;tr|A0A0J9YXB8|A0A0J9YXB8_HUMAN","sp|P07602|SAP_HUMAN;tr|C9JIZ6|C9JIZ6_HUMAN;tr|Q5BJH1|Q5BJH1_HUMAN",900,"P07602","SAP_HUMAN","Prosaposin",null,"PSAP"]
["13.1163","12.9106","12.9164","13.2969",{"$nulls":9},19,19,19,"8.4","8.4","8.4","358.62",0,"48.502",286310000,56,"0.149696",1,"-0.0932264","-0.431054","tr|A0A087WV66|A0A087WV66_HUMAN;sp|P46013|KI67_HUMAN","tr|A0A087WV66|A0A087WV66_HUMAN;sp|P46013|KI67_HUMAN",1501,"A0A087WV66"]
["25.2113","24.963","25.3687","24.9929",{"$nulls":3},"branched-chain amino acid catabolic process;lipid metabolic process;mitochondrial tRNA 3'-end processing;mitochondrial tRNA 5'-end processing;mitochondrial tRNA methylation;mitochondrial tRNA processing;mitochondrion organization;protein homotetramerization","3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity;3-hydroxyacyl-CoA dehydrogenase activity;cholate 7-alpha-dehydrogenase activity;RNA binding;testosterone dehydrogenase [NAD(P)] activity;tRNA binding","cytoplasm;mitochondrial matrix;mitochondrial ribonuclease P complex;mitochondrion;plasma membrane","Alzheimer disease;Metabolic pathways;Valine, leucine and isoleucine degradation",null,null,14,14,14,"88.9","88.9","88.9","26.923",0,"323.31",4292600000,159,"0.143894",1,"-0.0936298","-0.415728","sp|Q99714|HCD2_HUMAN;tr|Q5H928|Q5H928_HUMAN","sp|Q99714|HCD2_HUMAN;tr|Q5H928|Q5H928_HUMAN",3875,"Q99714","HCD2_HUMAN","3-hydroxyacyl-CoA dehydrogenase type-2",null,"HSD17B10"]
["16.1522","16.966","16.6974","16.6102",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;centriole-centriole cohesion;cilium assembly;intraciliary transport involved in cilium assembly;microtubule anchoring at centrosome;microtubule-based movement;neurogenesis;organelle organization;plus-end-directed vesicle transport along microtubule;retrograde vesicle-mediated transport, Golgi to ER","ATP binding;ATP-dependent microtubule motor activity, plus-end-directed;microtubule binding;Rab GTPase binding;spectrin binding","centriole;centrosome;ciliary tip;cilium;cytosol;extracellular exosome;kinesin II complex;microtubule;microtubule cytoskeleton","Hedgehog signaling pathway",null,null,3,2,2,"4.9","3.3","3.3","80.04","0.00024361","5.7818",29114000,2,"0.0764791",1,"-0.0946884","-0.231383","sp|Q9Y496|KIF3A_HUMAN;tr|J3KPF9|J3KPF9_HUMAN;tr|A0A087X011|A0A087X011_HUMAN;tr|E9PES4|E9PES4_HUMAN;tr|H7C2F6|H7C2F6_HUMAN","sp|Q9Y496|KIF3A_HUMAN;tr|J3KPF9|J3KPF9_HUMAN;tr|A0A087X011|A0A087X011_HUMAN;tr|E9PES4|E9PES4_HUMAN;tr|H7C2F6|H7C2F6_HUMAN",5007,"Q9Y496","KIF3A_HUMAN","Kinesin-like protein KIF3A",null,"KIF3A"]
["20.8458","21.3415","21.098","21.2797",{"$nulls":3},"axon guidance;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;Fc-epsilon receptor signaling pathway;leukocyte migration;MAPK cascade;neutrophil degranulation;positive regulation of endothelial cell proliferation;Ras protein signal transduction;stimulatory C-type lectin receptor signaling pathway","GTP binding;GTPase activity;protein complex binding","extracellular exosome;Golgi apparatus;Golgi membrane;membrane;plasma membrane;tertiary granule membrane","Acute myeloid leukemia;AGE-RAGE signaling pathway in diabetic complications;Alcoholism;Apelin signaling pathway;Apoptosis;Autophagy - animal;Axon guidance;B cell receptor signaling pathway;Bladder cancer;Breast cancer;Cellular senescence;Central carbon metabolism in cancer;Chemokine signaling pathway;Choline metabolism in cancer;Cholinergic synapse;Chronic myeloid leukemia;Colorectal cancer;C-type lectin receptor signaling pathway;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endometrial cancer;ErbB signaling pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;Insulin signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Longevity regulating pathway;Longevity regulating pathway - multiple species;Long-term depression;Long-term potentiation;MAPK signaling pathway;Melanogenesis;Melanoma;MicroRNAs in cancer;Mitophagy - animal;mTOR signaling pathway;Natural killer cell mediated cytotoxicity;Neurotrophin signaling pathway;Non-small cell lung cancer;Oxytocin signaling pathway;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Serotonergic synapse;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Thermogenesis;Thyroid cancer;Thyroid hormone signaling pathway;VEGF signaling pathway;Viral carcinogenesis",null,null,4,4,0,"25.4","25.4",0,"21.229",0,"16.702",197140000,25,"0.123274",1,"-0.0952129","-0.360667","sp|P01111|RASN_HUMAN","sp|P01111|RASN_HUMAN",815,"P01111","RASN_HUMAN","GTPase NRas",null,"NRAS"]
["21.0186",1,"21.2109",1,{"$nulls":3},"defense response to Gram-positive bacterium;negative regulation of cytokine secretion;negative regulation of phosphoprotein phosphatase activity;protein ubiquitination involved in ubiquitin-dependent protein catabolic process","protein phosphatase 1 binding;protein serine/threonine phosphatase inhibitor activity;ubiquitin protein ligase activity","cytoplasm;nucleus;protein phosphatase type 1 complex",{"$nulls":3},3,3,3,"41.3","41.3","41.3","13.952",0,"10.481",55937000,14,"0.00208085",1,"-0.0961485","-0.00675986","sp|O60927|PP1RB_HUMAN;tr|Q5SRK2|Q5SRK2_HUMAN","sp|O60927|PP1RB_HUMAN;tr|Q5SRK2|Q5SRK2_HUMAN",515,"O60927","PP1RB_HUMAN","E3 ubiquitin-protein ligase PPP1R11 {ECO:0000303|PubMed:27805901}",null,"PPP1R11"]
["22.9746","22.7225","23.2718","22.6194",{"$nulls":9},17,17,16,"39.3","39.3","36.6","62.035",0,"169.03",1730500000,82,"0.0928809",1,"-0.0970488","-0.27749","tr|E9PNQ6|E9PNQ6_HUMAN;tr|E9PIR7|E9PIR7_HUMAN;tr|F8W809|F8W809_HUMAN;tr|A0A087WSW9|A0A087WSW9_HUMAN;tr|A0A087WSY9|A0A087WSY9_HUMAN;sp|Q16881|TRXR1_HUMAN;tr|E2QRB9|E2QRB9_HUMAN;tr|E9PKD3|E9PKD3_HUMAN;tr|A0A0B4J225|A0A0B4J225_HUMAN;tr|E9PIZ5|E9PIZ5_HUMAN;tr|E9PLT3|E9PLT3_HUMAN;tr|E9PKI4|E9PKI4_HUMAN;tr|E9PQI3|E9PQI3_HUMAN;tr|E9PRI8|E9PRI8_HUMAN;tr|E9PJU2|E9PJU2_HUMAN;tr|A0A096LPK7|A0A096LPK7_HUMAN","tr|E9PNQ6|E9PNQ6_HUMAN;tr|E9PIR7|E9PIR7_HUMAN;tr|F8W809|F8W809_HUMAN;tr|A0A087WSW9|A0A087WSW9_HUMAN;tr|A0A087WSY9|A0A087WSY9_HUMAN;sp|Q16881|TRXR1_HUMAN;tr|E2QRB9|E2QRB9_HUMAN",5220,"E9PNQ6"]
["19.4518","20.4953","19.6948","20.4495",{"$nulls":3},"apoptotic process;cell migration;cell proliferation;cellular response to DNA damage stimulus;glucose metabolic process;mitochondrion localization;positive regulation of cell growth;positive regulation of protein phosphorylation;response to ionizing radiation",null,"cytoplasm;membrane;nucleoplasm;nucleus",{"$nulls":3},12,12,12,"23.5","23.5","23.5","88.118",0,"59.499",394230000,33,"0.0494786",1,"-0.098628","-0.153171","sp|Q6PJG6|BRAT1_HUMAN;tr|F8WDN5|F8WDN5_HUMAN","sp|Q6PJG6|BRAT1_HUMAN",2884,"Q6PJG6","BRAT1_HUMAN","BRCA1-associated ATM activator 1",null,"BRAT1"]
["17.4899","18.3541","17.6802","18.3617",{"$nulls":3},"calcium ion homeostasis;cellular protein metabolic process;endoplasmic reticulum calcium ion homeostasis;ER overload response;glucose homeostasis;IRE1-mediated unfolded protein response;kidney development;negative regulation of ATF6-mediated unfolded protein response;negative regulation of DNA binding transcription factor activity;negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;negative regulation of neuron apoptotic process;negative regulation of programmed cell death;negative regulation of transcription from RNA polymerase II promoter;negative regulation of type B pancreatic cell apoptotic process;nervous system process;olfactory behavior;pancreas development;positive regulation of adenylate cyclase activity;positive regulation of calcium ion transport;positive regulation of growth;positive regulation of protein metabolic process;positive regulation of protein ubiquitination;post-translational protein modification;protein maturation by protein folding;protein stabilization;renal water homeostasis;response to endoplasmic reticulum stress;sensory perception of sound;ubiquitin-dependent ERAD pathway;visual perception","activating transcription factor binding;ATPase binding;calcium-dependent protein binding;calmodulin binding;ubiquitin protein ligase binding","dendrite;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;proteasome complex","Protein processing in endoplasmic reticulum",null,null,8,8,8,"14.6","14.6","14.6","100.29",0,"19.031",78771000,18,"0.0585478",1,"-0.098937","-0.179795","sp|O76024|WFS1_HUMAN;tr|H0Y9G5|H0Y9G5_HUMAN","sp|O76024|WFS1_HUMAN;tr|H0Y9G5|H0Y9G5_HUMAN",640,"O76024","WFS1_HUMAN","Wolframin",null,"WFS1"]
["22.9977","22.5697","23.1754","22.5908",{"$nulls":3},"mRNA 3'-end processing;mRNA polyadenylation;mRNA processing;mRNA splicing, via spliceosome;protein tetramerization;termination of RNA polymerase II transcription","AU-rich element binding;histone deacetylase binding;hydrolase activity;identical protein binding;mRNA binding;protein homodimerization activity;RNA binding","centrosome;microtubule organizing center;mRNA cleavage factor complex;nuclear body;nucleoplasm;nucleus;paraspeckles","mRNA surveillance pathway",null,null,7,7,7,"40.1","40.1","40.1","26.227",0,"98.163",1057100000,70,"0.0917811",1,"-0.0994072","-0.274428","sp|O43809|CPSF5_HUMAN;tr|H3BND3|H3BND3_HUMAN;tr|H3BV41|H3BV41_HUMAN","sp|O43809|CPSF5_HUMAN;tr|H3BND3|H3BND3_HUMAN",437,"O43809","CPSF5_HUMAN","Cleavage and polyadenylation specificity factor subunit 5",null,"NUDT21"]
["23.641","21.496","23.0632","22.2726",{"$nulls":3},"metabolic process","catalytic activity;RNA binding",{"$nulls":4},11,2,0,"42.4","8.7",0,"35.904",0,"85.797",739650000,21,"0.0275167",1,"-0.0994291","-0.0869883","tr|M0QYT0|M0QYT0_HUMAN;tr|M0R076|M0R076_HUMAN","tr|M0QYT0|M0QYT0_HUMAN",5289,"M0QYT0","M0QYT0_HUMAN"]
["21.647","21.4931","21.8556","21.4864",{"$nulls":3},"cristae formation",null,"MICOS complex;mitochondrion",{"$nulls":3},9,9,9,"46.3","46.3","46.3","29.205",0,"82.331",1645200000,103,"0.177861",1,"-0.100929","-0.504582","tr|A0A087WYF7|A0A087WYF7_HUMAN;sp|Q6UXV4|MIC27_HUMAN;tr|A0A087WUX8|A0A087WUX8_HUMAN","tr|A0A087WYF7|A0A087WYF7_HUMAN;sp|Q6UXV4|MIC27_HUMAN;tr|A0A087WUX8|A0A087WUX8_HUMAN",2914,"A0A087WYF7","A0A087WYF7_HUMAN","MICOS complex subunit {ECO:0000256|RuleBase:RU363021}",null,"APOOL"]
["22.1047","22.007","22.389","21.9263",{"$nulls":5},"Golgi apparatus",{"$nulls":3},22,22,22,"29.5","29.5","29.5","114.16",0,"306.94",3381800000,118,"0.149468",1,"-0.101797","-0.430453","tr|A0A0A6YYL4|A0A0A6YYL4_HUMAN;sp|P57737|CORO7_HUMAN;tr|I3L167|I3L167_HUMAN;sp|Q9Y3D7|TIM16_HUMAN;tr|I3L0X9|I3L0X9_HUMAN;tr|I3L3T0|I3L3T0_HUMAN;tr|I3L1U7|I3L1U7_HUMAN;tr|E7EP81|E7EP81_HUMAN;tr|I3L442|I3L442_HUMAN;tr|I3L2Y6|I3L2Y6_HUMAN;tr|I3L212|I3L212_HUMAN;tr|A0A0B4J298|A0A0B4J298_HUMAN;tr|I3L359|I3L359_HUMAN;tr|I3L351|I3L351_HUMAN;tr|I3L1M1|I3L1M1_HUMAN;tr|I3L0X8|I3L0X8_HUMAN;tr|I3NI06|I3NI06_HUMAN;tr|I3L426|I3L426_HUMAN;tr|I3L1G9|I3L1G9_HUMAN","tr|A0A0A6YYL4|A0A0A6YYL4_HUMAN;sp|P57737|CORO7_HUMAN",5145,"A0A0A6YYL4","A0A0A6YYL4_HUMAN","Coronin {ECO:0000256|RuleBase:RU280818}",null,"CORO7-PAM16"]
["19.7482","20.278","19.7418","20.4901",{"$nulls":3},"DNA replication initiation;DNA replication, synthesis of RNA primer;G1/S transition of mitotic cell cycle;telomere maintenance via semi-conservative replication","4 iron, 4 sulfur cluster binding;DNA primase activity;DNA-directed DNA polymerase activity;metal ion binding;single-stranded DNA binding","alpha DNA polymerase:primase complex;nucleoplasm","DNA replication",null,null,10,10,10,"24.6","24.6","24.6","58.805",0,"27.178",260590000,29,"0.074025",1,"-0.10287","-0.224399","sp|P49643|PRI2_HUMAN;tr|A0A096LP51|A0A096LP51_HUMAN","sp|P49643|PRI2_HUMAN",1586,"P49643","PRI2_HUMAN","DNA primase large subunit",null,"PRIM2"]
["15.2029","15.768","15.7919","15.3852",{"$nulls":3},"cellular response to DNA damage stimulus;chromosome organization involved in meiotic cell cycle;DNA double-strand break processing;DNA duplex unwinding;DNA recombination;DNA repair;DNA replication;DNA synthesis involved in DNA repair;double-strand break repair;double-strand break repair via homologous recombination;double-strand break repair via nonhomologous end joining;negative regulation of telomere capping;nucleic acid phosphodiester bond hydrolysis;positive regulation of kinase activity;positive regulation of protein autophosphorylation;positive regulation of telomere maintenance;reciprocal meiotic recombination;regulation of mitotic recombination;regulation of signal transduction by p53 class mediator;strand displacement;telomere maintenance;telomere maintenance via recombination;telomere maintenance via telomerase;telomeric 3' overhang formation;viral process","adenylate kinase activity;ATP binding;ATPase activity;DNA binding;double-stranded telomeric DNA binding;G-quadruplex DNA binding;metal ion binding;protein binding, bridging;single-stranded telomeric DNA binding","condensed nuclear chromosome;membrane;Mre11 complex;nuclear chromatin;nuclear chromosome, telomeric region;nucleoplasm;site of double-strand break","Cellular senescence;Homologous recombination;Non-homologous end-joining",null,null,3,3,3,"2.6","2.6","2.6","153.89","0.00066756","4.1017",44016000,5,"0.0996113",1,"-0.103096","-0.296145","sp|Q92878|RAD50_HUMAN;tr|E7ESD9|E7ESD9_HUMAN;tr|E7EN38|E7EN38_HUMAN","sp|Q92878|RAD50_HUMAN",3543,"Q92878","RAD50_HUMAN","DNA repair protein RAD50","RAD50","RAD50"]
["21.3759","21.0413","21.456","21.1677",{"$nulls":3},"heme biosynthetic process;peptidyl-pyrromethane cofactor linkage;protoporphyrinogen IX biosynthetic process","hydroxymethylbilane synthase activity","cytoplasm;cytosol","Metabolic pathways;Porphyrin and chlorophyll metabolism",null,null,8,8,8,"29.1","29.1","29.1","39.33",0,"30.333",398810000,29,"0.16355",1,"-0.103225","-0.467389","sp|P08397|HEM3_HUMAN;tr|F5H345|F5H345_HUMAN;tr|F5GY90|F5GY90_HUMAN;tr|F5H226|F5H226_HUMAN;tr|F5H0P4|F5H0P4_HUMAN;tr|F5H4X2|F5H4X2_HUMAN;tr|F5H4W5|F5H4W5_HUMAN","sp|P08397|HEM3_HUMAN;tr|F5H345|F5H345_HUMAN;tr|F5GY90|F5GY90_HUMAN;tr|F5H226|F5H226_HUMAN;tr|F5H0P4|F5H0P4_HUMAN",922,"P08397","HEM3_HUMAN","Porphobilinogen deaminase","BG-D","HMBS"]
["18.0468",1,"18.2548",1,{"$nulls":4},"phosphatidate phosphatase activity","integral component of membrane",{"$nulls":3},2,2,2,"12.4","12.4","12.4","19.766","0.0017058","3.4756",16757000,6,"0.00264166",1,"-0.10401","-0.00857621","tr|K7EMK9|K7EMK9_HUMAN;tr|A0A0J9YXA3|A0A0J9YXA3_HUMAN;sp|O43688|LPP2_HUMAN;tr|K7ENH4|K7ENH4_HUMAN","tr|K7EMK9|K7EMK9_HUMAN;tr|A0A0J9YXA3|A0A0J9YXA3_HUMAN;sp|O43688|LPP2_HUMAN;tr|K7ENH4|K7ENH4_HUMAN",424,"K7EMK9","K7EMK9_HUMAN",null,null,"PLPP2"]
["18.3653",1,"18.5747",1,{"$nulls":5},"cytosol;nucleoplasm",{"$nulls":3},2,2,2,"59.1","59.1","59.1","7.2241","0.00067492","4.2274",33301000,7,"0.00261115",1,"-0.104725","-0.00847744","tr|F5GZF0|F5GZF0_HUMAN;sp|O14519|CDKA1_HUMAN","tr|F5GZF0|F5GZF0_HUMAN;sp|O14519|CDKA1_HUMAN",257,"F5GZF0","F5GZF0_HUMAN",null,null,"CDK2AP1"]
["25.3985","25.5515","25.657","25.5028",{"$nulls":3},"glucocorticoid catabolic process;glucocorticoid receptor signaling pathway;intracellular protein transport;membrane depolarization during action potential;membrane organization;negative regulation of dendrite morphogenesis;positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;positive regulation of transcription, DNA-templated;regulation of neuron differentiation;regulation of sodium ion transmembrane transporter activity;regulation of sodium ion transport;regulation of synaptic plasticity;substantia nigra development","actin binding;enzyme binding;glucocorticoid receptor binding;identical protein binding;insulin-like growth factor receptor binding;ion channel binding;protein domain specific binding;protein heterodimerization activity;sodium channel regulator activity","cytoplasm;cytoplasmic vesicle membrane;cytosol;extracellular exosome;intercalated disc;mitochondrion;plasma membrane","Cell cycle;Hepatitis C;Hippo signaling pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Viral carcinogenesis",null,null,16,13,13,"64.6","60.6","60.6","28.218",0,"323.31",6764500000,134,"0.360309",1,"-0.104858","-0.965384","sp|Q04917|1433F_HUMAN;tr|A2IDB2|A2IDB2_HUMAN;tr|F8WEB6|F8WEB6_HUMAN;tr|A2IDB1|A2IDB1_HUMAN","sp|Q04917|1433F_HUMAN",2096,"Q04917","1433F_HUMAN","14-3-3 protein eta",null,"YWHAH"]
["18.9452",1,"19.157",1,{"$nulls":3},"antigen processing and presentation;blood coagulation;complement-dependent cytotoxicity;cytotoxic T cell degranulation;exocytosis;exosomal secretion;melanocyte differentiation;melanosome localization;melanosome transport;multivesicular body organization;multivesicular body sorting pathway;natural killer cell degranulation;neutrophil degranulation;positive regulation of constitutive secretory pathway;positive regulation of exocytosis;positive regulation of gene expression;positive regulation of phagocytosis;positive regulation of reactive oxygen species biosynthetic process;positive regulation of regulated secretory pathway;protein targeting;synaptic vesicle transport","GDP binding;GTP binding;GTPase activity;myosin V binding;protein domain specific binding","apical plasma membrane;cytosol;dendrite;exocytic vesicle;extracellular exosome;extracellular region;Golgi apparatus;late endosome;lysosome;melanosome;melanosome membrane;multivesicular body membrane;photoreceptor outer segment;secretory granule;secretory granule membrane;specific granule lumen;synapse;Weibel-Palade body",{"$nulls":3},6,6,5,"28.5","28.5",24,"24.868",0,"9.2738",45674000,11,"0.00255537",1,"-0.105904","-0.00829687","sp|P51159|RB27A_HUMAN;tr|H3BN55|H3BN55_HUMAN;tr|H3BUD9|H3BUD9_HUMAN;tr|H3BS49|H3BS49_HUMAN;tr|H3BVH7|H3BVH7_HUMAN;tr|H3BU81|H3BU81_HUMAN","sp|P51159|RB27A_HUMAN;tr|H3BN55|H3BN55_HUMAN;tr|H3BUD9|H3BUD9_HUMAN;tr|H3BS49|H3BS49_HUMAN;tr|H3BVH7|H3BVH7_HUMAN;tr|H3BU81|H3BU81_HUMAN",1647,"P51159","RB27A_HUMAN","Ras-related protein Rab-27A","ab-27","RAB27A"]
["27.2028","27.2881","27.5672","27.1365",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of peptide antigen via MHC class I;cell redox homeostasis;positive regulation of extrinsic apoptotic signaling pathway;protein folding;protein folding in endoplasmic reticulum;protein import into nucleus;protein retention in ER lumen;response to endoplasmic reticulum stress;signal transduction","cysteine-type endopeptidase activity;disulfide oxidoreductase activity;identical protein binding;peptide disulfide oxidoreductase activity;phospholipase C activity;protein disulfide isomerase activity;RNA binding","cell surface;endoplasmic reticulum;endoplasmic reticulum lumen;extracellular exosome;extracellular space;focal adhesion;melanosome;myelin sheath;nucleus;phagocytic vesicle;recycling endosome membrane","Antigen processing and presentation;Epstein-Barr virus infection;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Protein processing in endoplasmic reticulum",null,null,32,32,27,63,63,"55.6","56.782",0,"323.31",43689000000,731,"0.170286",1,"-0.106447","-0.484935","sp|P30101|PDIA3_HUMAN","sp|P30101|PDIA3_HUMAN",1303,"P30101","PDIA3_HUMAN","Protein disulfide-isomerase A3",null,"PDIA3"]
["18.4449",1,"18.6597",1,{"$nulls":3},"fatty acid elongation;long-chain fatty-acyl-CoA biosynthetic process;sphingolipid biosynthetic process;very long-chain fatty acid biosynthetic process","3-hydroxyacyl-CoA dehydratase activity;3-hydroxy-arachidoyl-CoA dehydratase activity;3-hydroxy-behenoyl-CoA dehydratase activity;3-hydroxy-lignoceroyl-CoA dehydratase activity;3R-hydroxyacyl-CoA dehydratase activity;enzyme binding;very-long-chain 3-hydroxyacyl-CoA dehydratase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane","Biosynthesis of unsaturated fatty acids;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways",null,null,2,2,2,"8.7","8.7","8.7","28.368","0.0036984","2.983",57622000,0,"0.00266602",1,"-0.107423","-0.00865505","sp|Q6Y1H2|HACD2_HUMAN;tr|H7C4K8|H7C4K8_HUMAN;tr|C9JWG1|C9JWG1_HUMAN","sp|Q6Y1H2|HACD2_HUMAN;tr|H7C4K8|H7C4K8_HUMAN;tr|C9JWG1|C9JWG1_HUMAN",2922,"Q6Y1H2","HACD2_HUMAN","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 {ECO:0000305}",null,"HACD2"]
["17.4454","17.5837","17.6536","17.5905",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;cellular response to DNA damage stimulus;DNA repair;Fc-epsilon receptor signaling pathway;MAPK cascade;multicellular organism development;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasomal ubiquitin-independent protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;spermatogenesis, exchange of chromosomal proteins;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","lysine-acetylated histone binding;peptidase activator activity;proteasome binding","cytosol;nuclear speck;nucleoplasm;nucleus;proteasome core complex;spermatoproteasome complex","Proteasome",null,null,10,10,10,"8.4","8.4","8.4","211.33",0,"28.355",254270000,27,"0.533765",1,"-0.10755","-1.41549","sp|Q14997|PSME4_HUMAN;tr|F8WBH5|F8WBH5_HUMAN","sp|Q14997|PSME4_HUMAN",2409,"Q14997","PSME4_HUMAN","Proteasome activator complex subunit 4",null,"PSME4"]
["22.3243","22.7742","22.5407","22.7751",{"$nulls":3},"ATP hydrolysis coupled proton transport;ATP metabolic process;cellular iron ion homeostasis;cellular response to increased oxygen levels;insulin receptor signaling pathway;ion transmembrane transport;phagosome acidification;regulation of macroautophagy;transferrin transport;transport","ATP binding;proton-transporting ATPase activity, rotational mechanism","apical plasma membrane;cytosol;extracellular exosome;integral component of plasma membrane;lysosomal membrane;microvillus;mitochondrion;myelin sheath;plasma membrane;proton-transporting two-sector ATPase complex;proton-transporting V-type ATPase, V1 domain","Collecting duct acid secretion;Epithelial cell signaling in Helicobacter pylori infection;Human papillomavirus infection;Metabolic pathways;mTOR signaling pathway;Oxidative phosphorylation;Phagosome;Rheumatoid arthritis;Synaptic vesicle cycle;Vibrio cholerae infection",null,null,23,23,23,"55.6","55.6","55.6","68.303",0,"252.05",2084900000,118,"0.148699",1,"-0.108667","-0.428424","sp|P38606|VATA_HUMAN;tr|C9JA17|C9JA17_HUMAN;tr|C9JVW8|C9JVW8_HUMAN","sp|P38606|VATA_HUMAN",1426,"P38606","VATA_HUMAN","V-type proton ATPase catalytic subunit A",{"$f":"-ATPase subunit A","v":{"$error":"#NAME?"}},"ATP6V1A"]
["24.489","24.4704","24.6406","24.5372",{"$nulls":3},"cellular response to interleukin-4;circadian rhythm;GMP biosynthetic process;GTP biosynthetic process;lymphocyte proliferation;neutrophil degranulation;protein homotetramerization;purine ribonucleoside monophosphate biosynthetic process;retina development in camera-type eye","DNA binding;IMP dehydrogenase activity;metal ion binding;nucleotide binding;RNA binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;nucleus;peroxisomal membrane;secretory granule lumen","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism",null,null,24,24,22,"58.6","58.6","55.6","55.804",0,"319.75",4699700000,179,"0.762084",1,"-0.109245","-2.08072","sp|P12268|IMDH2_HUMAN;tr|H0Y4R1|H0Y4R1_HUMAN;tr|E7ETK5|E7ETK5_HUMAN","sp|P12268|IMDH2_HUMAN;tr|H0Y4R1|H0Y4R1_HUMAN",1011,"P12268","IMDH2_HUMAN","Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}","MP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156};MPD 2 {ECO:0000255|HAMAP-Rule:MF_03156};MPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}","IMPDH2"]
["20.5092","21.2976","21.1264","20.8995",{"$nulls":9},2,2,2,25,25,25,"13.389",0,"12.749",59306000,11,"0.0891707",1,"-0.10958","-0.267143","tr|K7EM09|K7EM09_HUMAN;tr|K7EPR0|K7EPR0_HUMAN;tr|K7ELQ9|K7ELQ9_HUMAN;sp|Q6UW68|TM205_HUMAN","tr|K7EM09|K7EM09_HUMAN;tr|K7EPR0|K7EPR0_HUMAN;tr|K7ELQ9|K7ELQ9_HUMAN;sp|Q6UW68|TM205_HUMAN",2903,"K7EM09","K7EM09_HUMAN",null,null,"TMEM205"]
["20.7578","20.546","20.9387","20.5845",{"$nulls":3},"dephosphorylation;glycerol biosynthetic process;glycerophospholipid metabolic process;negative regulation of gluconeogenesis;peptidyl-tyrosine dephosphorylation","glycerol-1-phosphatase activity;glycerol-3-phosphatase activity;magnesium ion binding;nucleotide phosphatase activity, acting on free nucleotides;phosphoglycolate phosphatase activity;phosphoprotein phosphatase activity;protein tyrosine phosphatase activity","cytosol","Carbon metabolism;Glyoxylate and dicarboxylate metabolism;Metabolic pathways",null,null,5,5,5,"19.6","19.6","19.6","34.006",0,"16.956",227910000,20,"0.188308",1,"-0.109672","-0.531541","sp|A6NDG6|PGP_HUMAN;tr|H3BV17|H3BV17_HUMAN","sp|A6NDG6|PGP_HUMAN",167,"A6NDG6","PGP_HUMAN","Glycerol-3-phosphate phosphatase {ECO:0000305}","3PP {ECO:0000303|PubMed:26755581}","PGP"]
["16.1571",1,"16.3792",1,{"$nulls":3},"carbohydrate metabolic process","beta-galactosidase activity","extracellular region;vacuole",{"$nulls":3},2,2,2,"5.5","5.5","5.5","72.078","0.0017109","3.5122",13284000,4,"0.00317073",1,"-0.111071","-0.0102877","sp|Q8IW92|GLBL2_HUMAN","sp|Q8IW92|GLBL2_HUMAN",3122,"Q8IW92","GLBL2_HUMAN","Beta-galactosidase-1-like protein 2",null,"GLB1L2"]
["19.2035","20.3403","19.2176","20.5493",{"$nulls":3},"cytokine-mediated signaling pathway;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;gene silencing by RNA;negative regulation of intracellular estrogen receptor signaling pathway;negative regulation of translation;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of ligand-dependent nuclear receptor transcription coactivator activity;positive regulation of peptidyl-serine phosphorylation;regulation of transcription, DNA-templated;sex differentiation;transcription, DNA-templated","epidermal growth factor receptor binding;kinase binding;protein domain specific binding;protein homodimerization activity","CCR4-NOT complex;CCR4-NOT core complex;cytosol;membrane;nucleus;P-body;protein complex","RNA degradation",null,null,5,5,5,"22.4","22.4","22.4","33.631",0,"16.084",132290000,15,"0.0408422",1,"-0.11158","-0.127449","sp|Q92600|RCD1_HUMAN;tr|F8WBZ6|F8WBZ6_HUMAN","sp|Q92600|RCD1_HUMAN",3503,"Q92600","CNOT9_HUMAN","CCR4-NOT transcription complex subunit 9 {ECO:0000312|HGNC:HGNC:10445}",null,"CNOT9"]
["19.1889","20.027","20.0126","19.4272",{"$nulls":3},"DNA replication;DNA replication, removal of RNA primer;mismatch repair;RNA catabolic process","metal ion binding;ribonuclease activity;RNA binding;RNA-DNA hybrid ribonuclease activity","cytosol;nucleoplasm;ribonuclease H2 complex","DNA replication",null,null,6,6,6,"34.1","34.1","34.1","33.395",0,"16.937",131540000,14,"0.0721606",1,"-0.111984","-0.219078","sp|O75792|RNH2A_HUMAN","sp|O75792|RNH2A_HUMAN",610,"O75792","RNH2A_HUMAN","Ribonuclease H2 subunit A","Nase H2 subunit A","RNASEH2A"]
["24.2689","23.4732","24.6029","23.366",{"$nulls":3},"aerobic respiration;aging;cellular response to growth factor stimulus;cellular response to oxidative stress;cholesterol metabolic process;hemoglobin metabolic process;hydrogen peroxide catabolic process;negative regulation of apoptotic process;negative regulation of NF-kappaB transcription factor activity;neutrophil degranulation;osteoblast differentiation;positive regulation of cell division;positive regulation of NF-kappaB transcription factor activity;positive regulation of phosphatidylinositol 3-kinase signaling;protein homotetramerization;protein tetramerization;response to activity;response to cadmium ion;response to drug;response to estradiol;response to ethanol;response to fatty acid;response to hydrogen peroxide;response to hyperoxia;response to hypoxia;response to inactivity;response to insulin;response to L-ascorbic acid;response to lead ion;response to light intensity;response to ozone;response to phenylpropanoid;response to reactive oxygen species;response to vitamin A;response to vitamin E;triglyceride metabolic process;ureteric bud development;UV protection","aminoacylase activity;antioxidant activity;catalase activity;enzyme binding;heme binding;metal ion binding;NADP binding;oxidoreductase activity, acting on peroxide as acceptor;protein homodimerization activity;receptor binding","cytosol;endoplasmic reticulum;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;focal adhesion;Golgi apparatus;intracellular membrane-bounded organelle;lysosome;membrane;mitochondrial intermembrane space;mitochondrion;peroxisomal matrix;peroxisomal membrane;peroxisome;plasma membrane;secretory granule lumen","Amyotrophic lateral sclerosis (ALS);Carbon metabolism;FoxO signaling pathway;Glyoxylate and dicarboxylate metabolism;Longevity regulating pathway;Longevity regulating pathway - multiple species;Metabolic pathways;Peroxisome;Tryptophan metabolism",null,null,24,24,24,"51.6","51.6","51.6","59.755",0,"248.27",4266500000,164,"0.049814",1,"-0.113364","-0.154162","sp|P04040|CATA_HUMAN","sp|P04040|CATA_HUMAN",828,"P04040","CATA_HUMAN","Catalase",null,"CAT"]
["25.4424","25.2703","25.6455","25.2954",{"$nulls":3},"DNA replication;mitochondrion morphogenesis;mitochondrion organization;positive regulation of helicase activity","chromatin binding;RNA binding;single-stranded DNA binding","extracellular exosome;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleus","DNA replication;Homologous recombination;Mismatch repair",null,null,6,6,6,"49.3","49.3","49.3","17.259",0,"305.42",3566600000,107,"0.209097",1,"-0.114083","-0.584779","sp|Q04837|SSBP_HUMAN;tr|A0A0G2JLD8|A0A0G2JLD8_HUMAN;tr|E7EUY5|E7EUY5_HUMAN;tr|C9K0U8|C9K0U8_HUMAN","sp|Q04837|SSBP_HUMAN;tr|A0A0G2JLD8|A0A0G2JLD8_HUMAN;tr|E7EUY5|E7EUY5_HUMAN;tr|C9K0U8|C9K0U8_HUMAN",2093,"Q04837","SSBP_HUMAN","Single-stranded DNA-binding protein, mitochondrial","tSSB;t-SSB","SSBP1"]
["17.8027","17.5609","17.9881","17.6049",{"$nulls":9},4,3,3,"21.5","17.1","17.1","25.411","0.00025887","7.1326",28796000,5,"0.178511",1,"-0.114692","-0.506264","tr|C9JRD2|C9JRD2_HUMAN;tr|C9JXB9|C9JXB9_HUMAN;sp|P25686|DNJB2_HUMAN;tr|C9J1G2|C9J1G2_HUMAN;tr|E7ETU0|E7ETU0_HUMAN;tr|C9JX00|C9JX00_HUMAN","tr|C9JRD2|C9JRD2_HUMAN;tr|C9JXB9|C9JXB9_HUMAN;sp|P25686|DNJB2_HUMAN;tr|C9J1G2|C9J1G2_HUMAN;tr|E7ETU0|E7ETU0_HUMAN;tr|C9JX00|C9JX00_HUMAN",1225,"C9JRD2","C9JRD2_HUMAN",null,null,"DNAJB2"]
["23.8506","24.0348","23.8075","24.3074",{"$nulls":3},"defense response to virus;immune response;negative regulation of viral entry into host cell;negative regulation of viral genome replication;negative regulation of viral transcription;response to interferon-alpha;response to interferon-beta;response to interferon-gamma;response to virus;type I interferon signaling pathway",null,"extracellular exosome;integral component of membrane;late endosome membrane;lysosomal membrane;plasma membrane",{"$nulls":3},2,2,2,"30.1","30.1","30.1","14.632",0,"30.516",524760000,23,"0.149599",1,"-0.11474","-0.430799","sp|Q01628|IFM3_HUMAN;tr|H7BYV1|H7BYV1_HUMAN;tr|E9PS44|E9PS44_HUMAN;tr|E9PQN9|E9PQN9_HUMAN;sp|P13164|IFM1_HUMAN;sp|Q01629|IFM2_HUMAN;sp|C9JQL5|DSA2D_HUMAN","sp|Q01628|IFM3_HUMAN;tr|H7BYV1|H7BYV1_HUMAN;tr|E9PS44|E9PS44_HUMAN;tr|E9PQN9|E9PQN9_HUMAN;sp|P13164|IFM1_HUMAN;sp|Q01629|IFM2_HUMAN;sp|C9JQL5|DSA2D_HUMAN",2049,"Q01628","IFM3_HUMAN","Interferon-induced transmembrane protein 3",null,"IFITM3"]
["24.9623","24.5988","25.0304","24.764",{"$nulls":3},"2-oxoglutarate metabolic process;aging;branched-chain amino acid catabolic process;cell redox homeostasis;cellular nitrogen compound metabolic process;dihydrolipoamide metabolic process;gastrulation;lipoate metabolic process;lysine catabolic process;mitochondrial acetyl-CoA biosynthetic process from pyruvate;mitochondrial electron transport, NADH to ubiquinone;proteolysis;pyruvate metabolic process;regulation of acetyl-CoA biosynthetic process from pyruvate;regulation of membrane potential;sperm capacitation;tricarboxylic acid cycle","dihydrolipoyl dehydrogenase activity;electron transfer activity;flavin adenine dinucleotide binding;lipoamide binding;NAD binding","acrosomal matrix;mitochondrial matrix;mitochondrion;motile cilium;myelin sheath;nucleoplasm;oxoglutarate dehydrogenase complex;pyruvate dehydrogenase complex","Carbon metabolism;Citrate cycle (TCA cycle);Glycine, serine and threonine metabolism;Glycolysis / Gluconeogenesis;Glyoxylate and dicarboxylate metabolism;Lysine degradation;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism;Tryptophan metabolism;Valine, leucine and isoleucine degradation",null,null,16,16,16,"43.2","43.2","43.2","54.177",0,177,5428400000,140,"0.182884",1,"-0.116609","-0.517562","sp|P09622|DLDH_HUMAN;tr|E9PEX6|E9PEX6_HUMAN;tr|F8WDM5|F8WDM5_HUMAN;tr|F2Z2E3|F2Z2E3_HUMAN","sp|P09622|DLDH_HUMAN;tr|E9PEX6|E9PEX6_HUMAN",950,"P09622","DLDH_HUMAN","Dihydrolipoyl dehydrogenase, mitochondrial",null,"DLD"]
["18.3013",1,"18.5371",1,{"$nulls":3},"cell adhesion;mRNA splicing, via spliceosome;regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;RNA binding;structural molecule activity","catalytic step 2 spliceosome;cell-cell junction;desmosome;intermediate filament;membrane;nuclear speck;plasma membrane","mRNA surveillance pathway;RNA transport",null,null,8,8,8,"16.3","16.3","16.3","81.613",0,"18.845",135480000,21,"0.00294947",1,"-0.117906","-0.00957218","sp|Q9H307|PININ_HUMAN;tr|G3V5F0|G3V5F0_HUMAN;tr|G3V579|G3V579_HUMAN","sp|Q9H307|PININ_HUMAN",4181,"Q9H307","PININ_HUMAN","Pinin",null,"PNN"]
["17.0269",1,"17.2635",1,{"$nulls":3},"cellular response to interferon-gamma;Golgi organization;phagosome maturation;retrograde transport, plasma membrane to Golgi;toxin transport;virion assembly","GTP binding;GTPase activity","endosome;extracellular exosome;Golgi apparatus;phagocytic vesicle;phagocytic vesicle membrane;trans-Golgi network membrane",{"$nulls":3},1,1,1,"5.2","5.2","5.2","23.339","0.0065256","2.5514",12873000,2,"0.00319392",1,"-0.118307","-0.0103626","sp|Q86YS6|RAB43_HUMAN","sp|Q86YS6|RAB43_HUMAN",3095,"Q86YS6","RAB43_HUMAN","Ras-related protein Rab-43",null,"RAB43"]
["25.4979","25.1781","25.5114","25.4024",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;membrane","Ribosome",null,null,8,8,8,"41.2","41.2","41.2","18.565",0,"135.63",9274900000,280,"0.256144",1,"-0.118931","-0.703838","sp|P46778|RL21_HUMAN;tr|M0R181|M0R181_HUMAN;tr|G3V1B3|G3V1B3_HUMAN","sp|P46778|RL21_HUMAN;tr|M0R181|M0R181_HUMAN;tr|G3V1B3|G3V1B3_HUMAN",1515,"P46778","RL21_HUMAN","60S ribosomal protein L21",null,"RPL21"]
["21.182","22.4692","21.9448","21.9451",{"$nulls":3},"aerobic respiration;AMP biosynthetic process;'de novo' AMP biosynthetic process;'de novo' IMP biosynthetic process;protein tetramerization;purine nucleotide biosynthetic process;purine ribonucleoside monophosphate biosynthetic process;response to hypoxia;response to muscle activity;response to nutrient;response to starvation","(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity;N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity","cytosol;mitochondrion","Alanine, aspartate and glutamate metabolism;Metabolic pathways;Purine metabolism",null,null,15,15,15,"42.4","42.4","42.4","54.889",0,"96.68",773650000,46,"0.0604811",1,"-0.119338","-0.185422","sp|P30566|PUR8_HUMAN;tr|A0A0A6YY92|A0A0A6YY92_HUMAN;tr|A0A096LNY6|A0A096LNY6_HUMAN;tr|A0A096LNY5|A0A096LNY5_HUMAN;tr|A0A096LPA2|A0A096LPA2_HUMAN;tr|A0A096LNY4|A0A096LNY4_HUMAN;tr|A0A096LNT4|A0A096LNT4_HUMAN;tr|A0A096LP92|A0A096LP92_HUMAN;tr|A0A096LP76|A0A096LP76_HUMAN;tr|B4DEP1|B4DEP1_HUMAN;tr|A0A096LP72|A0A096LP72_HUMAN;tr|V9GY96|V9GY96_HUMAN;tr|A0A096LNT0|A0A096LNT0_HUMAN","sp|P30566|PUR8_HUMAN;tr|A0A0A6YY92|A0A0A6YY92_HUMAN;tr|A0A096LNY6|A0A096LNY6_HUMAN",1315,"P30566","PUR8_HUMAN","Adenylosuccinate lyase {ECO:0000303|PubMed:8404037}","DSL {ECO:0000303|PubMed:8404037};SL","ADSL"]
["28.9984","28.9615","29.2514","28.9492",{"$nulls":3},"ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;microtubule-based process;movement of cell or subcellular component;natural killer cell mediated cytotoxicity;neutrophil degranulation;regulation of G2/M transition of mitotic cell cycle","double-stranded RNA binding;GTP binding;GTPase activity;MHC class I protein binding;structural constituent of cytoskeleton;unfolded protein binding","azurophil granule lumen;cytoskeleton;cytosol;extracellular exosome;extracellular matrix;extracellular region;extracellular vesicle;microtubule;microtubule cytoskeleton;myelin sheath;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,27,27,4,"66.3","66.3",13,"49.83",0,"323.31",115400000000000,2654,"0.290618",1,"-0.120317","-0.790396","sp|P68371|TBB4B_HUMAN;sp|P04350|TBB4A_HUMAN;tr|M0R2D3|M0R2D3_HUMAN;tr|M0QY85|M0QY85_HUMAN;tr|M0R0X0|M0R0X0_HUMAN;tr|M0QY37|M0QY37_HUMAN;tr|M0QX14|M0QX14_HUMAN;tr|M0QZL7|M0QZL7_HUMAN;tr|M0QYM7|M0QYM7_HUMAN;tr|M0R278|M0R278_HUMAN;tr|M0R042|M0R042_HUMAN;tr|M0R2T4|M0R2T4_HUMAN;tr|A0A075B724|A0A075B724_HUMAN","sp|P68371|TBB4B_HUMAN;sp|P04350|TBB4A_HUMAN",1962,"P68371","TBB4B_HUMAN","Tubulin beta-4B chain",null,"TUBB4B"]
["19.6545","19.9212","19.8614","19.9562",{"$nulls":3},"tRNA processing","nucleic acid binding;ribonuclease P activity","nucleus",{"$nulls":3},1,1,1,"10.9","10.9","10.9","15.324","0.0021272","3.4569",48448000,6,"0.316303",1,"-0.120938","-0.854786","tr|C9JYM0|C9JYM0_HUMAN;sp|O75817|POP7_HUMAN","tr|C9JYM0|C9JYM0_HUMAN;sp|O75817|POP7_HUMAN",614,"C9JYM0","C9JYM0_HUMAN",null,null,"POP7"]
["27.0043","27.0588","27.1523","27.1533",{"$nulls":3},"aldehyde catabolic process;angiogenesis;canonical glycolysis;carbohydrate metabolic process;erythrocyte homeostasis;gluconeogenesis;glucose 6-phosphate metabolic process;glucose homeostasis;hemostasis;humoral immune response;in utero embryonic development;learning or memory;mesoderm formation;methylglyoxal biosynthetic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of neuron apoptotic process;neutrophil degranulation;positive regulation of immunoglobulin secretion;response to cadmium ion;response to estradiol;response to immobilization stress;response to morphine;response to muscle stretch;response to progesterone;response to testosterone","cytokine activity;glucose-6-phosphate isomerase activity;growth factor activity;intramolecular transferase activity;monosaccharide binding;ubiquitin protein ligase binding","ciliary membrane;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;myelin sheath;neuron projection;nucleoplasm;plasma membrane;secretory granule lumen","Amino sugar and nucleotide sugar metabolism;Carbon metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways;Pentose phosphate pathway;Starch and sucrose metabolism",null,null,27,27,20,"58.2","58.2","38.7","63.146",0,"323.31",29847000000,558,"1.32848",1,"-0.121264","-4.45163","sp|P06744|G6PI_HUMAN;tr|A0A0A0MTS2|A0A0A0MTS2_HUMAN;tr|K7EQ48|K7EQ48_HUMAN;tr|A0A0J9YXP8|A0A0J9YXP8_HUMAN;tr|A0A0J9YYH3|A0A0J9YYH3_HUMAN;tr|A0A0J9YX90|A0A0J9YX90_HUMAN;tr|K7EPY4|K7EPY4_HUMAN;tr|K7EP41|K7EP41_HUMAN;tr|K7ENA0|K7ENA0_HUMAN;tr|K7ERC6|K7ERC6_HUMAN;tr|K7ELR7|K7ELR7_HUMAN;tr|K7ERK8|K7ERK8_HUMAN;tr|K7EIL4|K7EIL4_HUMAN;tr|K7ESF4|K7ESF4_HUMAN;sp|Q8N196|SIX5_HUMAN","sp|P06744|G6PI_HUMAN;tr|A0A0A0MTS2|A0A0A0MTS2_HUMAN;tr|K7EQ48|K7EQ48_HUMAN;tr|A0A0J9YXP8|A0A0J9YXP8_HUMAN;tr|A0A0J9YYH3|A0A0J9YYH3_HUMAN",881,"P06744","G6PI_HUMAN","Glucose-6-phosphate isomerase","PI","GPI"]
["17.0503","16.1572","17.3746","16.0767",{"$nulls":3},"glycerol catabolic process;glycerol metabolic process;glycerol-3-phosphate biosynthetic process;triglyceride metabolic process","ATP binding;glycerol kinase activity","mitochondrial outer membrane;mitochondrion",{"$nulls":3},3,3,3,"6.3","6.3","6.3","60.597","0.00046501","4.8333",115820000,6,"0.0500263",1,"-0.121934","-0.15479","sp|Q14409|GLPK3_HUMAN;sp|P32189|GLPK_HUMAN;tr|F8WC39|F8WC39_HUMAN;tr|A6NP46|A6NP46_HUMAN;tr|H7C2A0|H7C2A0_HUMAN","sp|Q14409|GLPK3_HUMAN;sp|P32189|GLPK_HUMAN",1347,"Q14409","GLPK3_HUMAN","Glycerol kinase 3 {ECO:0000305}","K 3;lycerokinase 3","GK3P"]
["19.7014","19.0432","19.9831","19.0063",{"$nulls":3},"actin filament organization;cell junction assembly;cell migration;establishment of epithelial cell apical/basal polarity;filopodium assembly;negative regulation of small GTPase mediated signal transduction;phagocytosis, engulfment;positive regulation of GTPase activity;regulation of actin cytoskeleton organization;regulation of actin filament depolymerization;regulation of blood vessel endothelial cell migration;semaphorin-plexin signaling pathway","GTPase activator activity;semaphorin receptor binding;SH3 domain binding","adherens junction;bicellular tight junction;cell leading edge;cytosol;lamellipodium;nucleus;phagocytic cup",{"$nulls":3},11,11,11,"23.7","23.7","23.7","75.712",0,"36.35",229220000,37,"0.0682696",1,"-0.122454","-0.207929","sp|Q9Y3L3|3BP1_HUMAN","sp|Q9Y3L3|3BP1_HUMAN",4993,"Q9Y3L3","3BP1_HUMAN","SH3 domain-binding protein 1 {ECO:0000312|HGNC:HGNC:10824}",null,"SH3BP1"]
["18.8938","17.4401","18.4318","18.1488",{"$nulls":3},"formation of translation preinitiation complex;intracellular protein transport;IRES-dependent viral translational initiation;ribosome disassembly","receptor activity;translation initiation factor activity","cytoplasm;cytosol;nuclear body",{"$nulls":3},6,6,6,"17.5","17.5","17.5","64.706",0,"13.525",132890000,24,"0.0540327",1,"-0.123353","-0.166588","sp|P41214|EIF2D_HUMAN;tr|Q5SY38|Q5SY38_HUMAN;tr|A0A087X1L6|A0A087X1L6_HUMAN","sp|P41214|EIF2D_HUMAN;tr|Q5SY38|Q5SY38_HUMAN",1451,"P41214","EIF2D_HUMAN","Eukaryotic translation initiation factor 2D","IF2d","EIF2D"]
["23.9498","23.4151","23.9643","23.6478",{"$nulls":3},"cellular response to leukemia inhibitory factor;chromosome segregation;negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of cell proliferation;regulation of insulin secretion;transport;viral process","adenine transmembrane transporter activity;ATP:ADP antiporter activity;RNA binding;ubiquitin protein ligase binding","extracellular exosome;extracellular matrix;integral component of plasma membrane;membrane;membrane raft;mitochondrial inner membrane;mitochondrial nucleoid;mitochondrion;MMXD complex;myelin sheath;nucleus","Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;Human T-cell leukemia virus 1 infection;Huntington disease;Influenza A;Necroptosis;Parkinson disease",null,null,18,7,7,"45.6","19.8","19.8","32.852",0,"32.276",7658200000,217,"0.137193",1,"-0.123629","-0.397938","sp|P05141|ADT2_HUMAN","sp|P05141|ADT2_HUMAN",857,"P05141","ADT2_HUMAN","ADP/ATP translocase 2",null,"SLC25A5"]
["26.1592","25.9631","26.2847","26.0871",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;defense response to Gram-negative bacterium;erythrocyte differentiation;killing of cells of other organism;maturation of SSU-rRNA;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);monocyte chemotaxis;negative regulation of respiratory burst involved in inflammatory response;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nucleolus organization;positive regulation of cellular component movement;positive regulation of respiratory burst involved in inflammatory response;protein tetramerization;response to extracellular stimulus;ribosomal small subunit assembly;ribosomal small subunit biogenesis;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","fibroblast growth factor binding;protein homodimerization activity;protein kinase binding;RNA binding;structural constituent of ribosome","cytoplasm;cytosol;cytosolic small ribosomal subunit;extracellular exosome;extracellular matrix;focal adhesion;membrane;nucleolus;nucleoplasm;ribosome","Ribosome",null,null,13,13,13,"62.8","62.8","62.8","16.06",0,"112.99",33271000000,476,"0.332779",1,"-0.124749","-0.896128","sp|P39019|RS19_HUMAN;tr|A0A075B6E2|A0A075B6E2_HUMAN;tr|M0R2L9|M0R2L9_HUMAN;tr|M0QXK4|M0QXK4_HUMAN;tr|M0QYF7|M0QYF7_HUMAN;tr|M0R140|M0R140_HUMAN","sp|P39019|RS19_HUMAN;tr|A0A075B6E2|A0A075B6E2_HUMAN",1429,"P39019","RS19_HUMAN","40S ribosomal protein S19",null,"RPS19"]
["23.5099","23.5837","23.7143","23.6291",{"$nulls":3},"ER to Golgi vesicle-mediated transport;Golgi organization;post-translational protein modification;protein transport","GDP binding;GTP binding;GTPase activity","cytosol;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;Golgi apparatus;Golgi membrane;lysosomal membrane;melanosome;nucleus","AMPK signaling pathway",null,null,11,11,4,"56.1","56.1","24.1","23.545",0,"158.23",1448600000,73,"0.804133",1,"-0.124899","-2.21641","sp|P61019|RAB2A_HUMAN;tr|E9PKL7|E9PKL7_HUMAN;tr|Q5HYI5|Q5HYI5_HUMAN;tr|H7C125|H7C125_HUMAN;tr|E9PE37|E9PE37_HUMAN;tr|H0YD31|H0YD31_HUMAN;tr|H0YDL5|H0YDL5_HUMAN;tr|Q6PIK3|Q6PIK3_HUMAN","sp|P61019|RAB2A_HUMAN;tr|E9PKL7|E9PKL7_HUMAN;tr|Q5HYI5|Q5HYI5_HUMAN",1823,"P61019","RAB2A_HUMAN","Ras-related protein Rab-2A",null,"RAB2A"]
["20.0865","21.1486","20.5102","20.9776",{"$nulls":3},"cell division;ER to Golgi vesicle-mediated transport;establishment of mitotic spindle orientation;Golgi organization;meiotic cell cycle;mitotic cell cycle checkpoint;mitotic metaphase plate congression;mitotic sister chromatid segregation;mitotic spindle assembly checkpoint;protein complex assembly;protein localization to kinetochore;protein transport;regulation of exit from mitosis;retrograde vesicle-mediated transport, Golgi to ER;sister chromatid cohesion","centromeric DNA binding","condensed chromosome kinetochore;cytosol;Dsl1/NZR complex;endoplasmic reticulum;endoplasmic reticulum membrane;kinetochore;kinetochore microtubule;membrane;nucleus;RZZ complex;spindle pole",{"$nulls":3},17,17,17,"28.8","28.8","28.8","88.828",0,"98.402",570500000,50,"0.0717119",1,"-0.126359","-0.217796","sp|O43264|ZW10_HUMAN;tr|F5H3C1|F5H3C1_HUMAN","sp|O43264|ZW10_HUMAN",384,"O43264","ZW10_HUMAN","Centromere/kinetochore protein zw10 homolog",null,"ZW10"]
["21.6292","21.7073","22.0108","21.5788",{"$nulls":9},16,16,16,"29.3","29.3","29.3","113.63",0,"78.203",822110000,86,"0.206004",1,"-0.126625","-0.57689","tr|F8W726|F8W726_HUMAN;sp|Q14157|UBP2L_HUMAN;tr|Q5VU77|Q5VU77_HUMAN;tr|Q5VU79|Q5VU79_HUMAN;tr|Q5VU78|Q5VU78_HUMAN;tr|Q5VU81|Q5VU81_HUMAN;tr|Q5VU80|Q5VU80_HUMAN;tr|H0Y5H6|H0Y5H6_HUMAN;tr|H7C2T8|H7C2T8_HUMAN","tr|F8W726|F8W726_HUMAN;sp|Q14157|UBP2L_HUMAN;tr|Q5VU77|Q5VU77_HUMAN",2338,"F8W726","F8W726_HUMAN",null,null,"UBAP2L"]
["27.2492","26.8025","27.3159","26.991",{"$nulls":3},"canonical glycolysis;cellular response to hypoxia;epithelial cell differentiation;gluconeogenesis;glycolytic process;negative regulation of angiogenesis;phosphorylation;plasminogen activation","ATP binding;phosphoglycerate kinase activity;protein-disulfide reductase activity","cytosol;extracellular exosome;extracellular space;membrane;membrane raft","Biosynthesis of amino acids;Carbon metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways",null,null,26,26,26,"73.9","73.9","73.9","44.614",0,"323.31",31481000000,639,"0.161467",1,"-0.127566","-0.461949","sp|P00558|PGK1_HUMAN;sp|P07205|PGK2_HUMAN","sp|P00558|PGK1_HUMAN",806,"P00558","PGK1_HUMAN","Phosphoglycerate kinase 1",null,"PGK1"]
["16.7387","16.6069","17.1488","16.453",{"$nulls":3},"angiogenesis;cell differentiation;exocyst localization;exocytosis","SNARE binding","exocyst;extracellular space",{"$nulls":3},1,1,1,"2.4","2.4","2.4","72.66","0.005413","2.67",296090000,18,"0.123653",1,"-0.128061","-0.361687","sp|Q03169|TNAP2_HUMAN","sp|Q03169|TNAP2_HUMAN",2081,"Q03169","TNAP2_HUMAN","Tumor necrosis factor alpha-induced protein 2","NF alpha-induced protein 2","TNFAIP2"]
["20.1416","19.7639","20.3628","19.8015",{"$nulls":3},"cell division;DNA repair;meiotic cell cycle;mitotic sister chromatid cohesion;mitotic sister chromatid segregation;negative regulation of DNA endoreduplication;regulation of mitotic spindle assembly;response to DNA damage checkpoint signaling;response to radiation;sister chromatid cohesion;stem cell population maintenance","ATP binding;chromatin binding;mediator complex binding;protein heterodimerization activity;RNA binding","chromosome;chromosome, centromeric region;cohesin complex;condensed chromosome kinetochore;condensed nuclear chromosome;cytosol;kinetochore;meiotic cohesin complex;mitotic spindle pole;nuclear matrix;nucleoplasm;nucleus","Cell cycle;Oocyte meiosis",null,null,34,34,34,"31.4","31.4","31.4","143.23",0,"82.859",1246500000,117,"0.13142",1,"-0.129403","-0.382536","sp|Q14683|SMC1A_HUMAN;tr|G8JLG1|G8JLG1_HUMAN;tr|H0Y7K8|H0Y7K8_HUMAN;tr|V9GY57|V9GY57_HUMAN;tr|V9GYN9|V9GYN9_HUMAN","sp|Q14683|SMC1A_HUMAN;tr|G8JLG1|G8JLG1_HUMAN",2380,"Q14683","SMC1A_HUMAN","Structural maintenance of chromosomes protein 1A","MC protein 1A;MC-1A;MC-1-alpha","SMC1A"]
["22.8921","22.5321","23.0127","22.6712",{"$nulls":3},"apoptotic process;cell cycle;mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","intracellular ribonucleoprotein complex;mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrion",{"$nulls":3},6,6,6,"51.8","51.8","51.8","15.383",0,"82.499",391280000,23,"0.185149",1,"-0.129852","-0.523404","sp|Q8IXM3|RM41_HUMAN","sp|Q8IXM3|RM41_HUMAN",3148,"Q8IXM3","RM41_HUMAN","39S ribosomal protein L41, mitochondrial","41mt;RP-L41","MRPL41"]
["14.0076",1,"14.268",1,{"$nulls":3},"bone development;face morphogenesis;in utero embryonic development;multicellular organism growth;odontogenesis of dentin-containing tooth;skeletal system morphogenesis;tissue homeostasis",null,"cytosol;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},10,10,10,"5.8","5.8","5.8","297.91",0,"24.435",144280000,35,"0.00432512",1,"-0.130202","-0.0140149","sp|Q6UB99|ANR11_HUMAN","sp|Q6UB99|ANR11_HUMAN",2899,"Q6UB99","ANR11_HUMAN","Ankyrin repeat domain-containing protein 11",null,"ANKRD11"]
["22.6718","22.8802","22.8504","22.9623",{"$nulls":3},"cellular amino acid biosynthetic process;glutamate biosynthetic process;glutamate catabolic process;glutamine metabolic process;mitochondrion organization;positive regulation of insulin secretion;substantia nigra development;tricarboxylic acid metabolic process","ADP binding;ATP binding;glutamate dehydrogenase (NAD+) activity;glutamate dehydrogenase [NAD(P)+] activity;GTP binding;identical protein binding;leucine binding;NAD+ binding","cytoplasm;mitochondrial matrix;mitochondrion","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Carbon metabolism;D-Glutamine and D-glutamate metabolism;Metabolic pathways;Necroptosis;Nitrogen metabolism;Proximal tubule bicarbonate reclamation",null,null,20,20,20,"49.3","49.3","49.3","61.397",0,"117.93",2446000000,143,"0.414279",1,"-0.130374","-1.10233","sp|P00367|DHE3_HUMAN;sp|P49448|DHE4_HUMAN","sp|P00367|DHE3_HUMAN;sp|P49448|DHE4_HUMAN",796,"P00367","DHE3_HUMAN","Glutamate dehydrogenase 1, mitochondrial","DH 1","GLUD1"]
["23.6569","23.5624","23.8634","23.618",{"$nulls":3},"4-hydroxyproline metabolic process;cell redox homeostasis;extracellular matrix organization;I-kappaB phosphorylation;male gonad development;negative regulation of male germ cell proliferation;neutrophil degranulation;protein maturation by protein folding;reactive oxygen species metabolic process;spermatogenesis","protein homodimerization activity;thioredoxin peroxidase activity","cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;mitochondrion;nucleus;secretory granule lumen;smooth endoplasmic reticulum",{"$nulls":3},14,11,11,62,"52.8","52.8","30.54",0,"74.06",1811900000,80,"0.372607",1,"-0.131042","-0.99643","sp|Q13162|PRDX4_HUMAN;tr|H7C3T4|H7C3T4_HUMAN;tr|A6NJJ0|A6NJJ0_HUMAN;tr|A6NG45|A6NG45_HUMAN","sp|Q13162|PRDX4_HUMAN;tr|H7C3T4|H7C3T4_HUMAN",2216,"Q13162","PRDX4_HUMAN","Peroxiredoxin-4",null,"PRDX4"]
["23.4983","23.486","23.6256","23.6209",{"$nulls":3},"positive regulation of proteasomal ubiquitin-dependent protein catabolic process;protein deubiquitination;protein K48-linked deubiquitination;protein ubiquitination;ubiquitin-dependent protein catabolic process","cysteine-type endopeptidase activity;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitin binding;zinc ion binding","cytosol;lysosome",{"$nulls":3},30,30,30,"46.6","46.6","46.6","95.785",0,"323.31",4034400000,173,"2.60438",1,"-0.131064","-20.016","sp|P45974|UBP5_HUMAN;tr|F5H571|F5H571_HUMAN","sp|P45974|UBP5_HUMAN",1499,"P45974","UBP5_HUMAN","Ubiquitin carboxyl-terminal hydrolase 5",null,"USP5"]
["15.9959","16.596","16.0434","16.8129",{"$nulls":3},"cell cycle","GTP binding","cytosol;nucleus",{"$nulls":3},2,2,2,3,3,3,"104.99","0.0098058","2.225",43961000,1,"0.0905258",1,"-0.132186","-0.270927","sp|Q8TCY9|URGCP_HUMAN;tr|C9J0W2|C9J0W2_HUMAN;tr|C9JKA8|C9JKA8_HUMAN;tr|F8WCC3|F8WCC3_HUMAN","sp|Q8TCY9|URGCP_HUMAN;tr|C9J0W2|C9J0W2_HUMAN;tr|C9JKA8|C9JKA8_HUMAN;tr|F8WCC3|F8WCC3_HUMAN",3379,"Q8TCY9","URGCP_HUMAN","Up-regulator of cell proliferation",null,"URGCP"]
["20.5277","20.7131","21.0253","20.4816",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;cellular protein modification process;exit from mitosis;free ubiquitin chain polymerization;positive regulation of ubiquitin protein ligase activity;protein K11-linked ubiquitination;protein K27-linked ubiquitination;protein K29-linked ubiquitination;protein K63-linked ubiquitination;protein K6-linked ubiquitination;protein ubiquitination","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","anaphase-promoting complex;cytoplasm;cytosol;nucleoplasm","Ubiquitin mediated proteolysis",null,null,5,5,5,"34.2","34.2","34.2","23.845",0,"18.681",187160000,28,"0.16194",1,"-0.133026","-0.463186","sp|Q16763|UBE2S_HUMAN;tr|K7EPJ1|K7EPJ1_HUMAN;tr|K7EM75|K7EM75_HUMAN","sp|Q16763|UBE2S_HUMAN;tr|K7EPJ1|K7EPJ1_HUMAN",2570,"Q16763","UBE2S_HUMAN","Ubiquitin-conjugating enzyme E2 S",null,"UBE2S"]
["18.9181","17.5532","18.5956","18.1453",{"$nulls":3},"endocytic recycling;endocytosis;positive regulation of histamine secretion by mast cell;protein transport;vesicle organization","epidermal growth factor receptor binding;insulin receptor binding;leptin receptor binding;phosphatidylinositol binding;transferrin receptor binding","cytoplasm;cytoplasmic dynein complex;early endosome membrane;extrinsic component of membrane;membrane;plasma membrane;protein complex;SNARE complex","Endocytosis",null,null,4,4,4,"10.7","10.7","10.7","51.908",0,"9.6229",96467000,13,"0.0612243",1,"-0.134799","-0.187581","sp|O95219|SNX4_HUMAN;tr|F8W9T3|F8W9T3_HUMAN","sp|O95219|SNX4_HUMAN;tr|F8W9T3|F8W9T3_HUMAN",704,"O95219","SNX4_HUMAN","Sorting nexin-4",null,"SNX4"]
["15.7239","17.1374","16.7865","16.3457",{"$nulls":9},5,3,3,"8.9","5.7","5.7","81.379","0.00026455","7.5363",34112000,9,"0.0596209",1,"-0.135417","-0.182921","tr|E9PP16|E9PP16_HUMAN;sp|Q8ND30|LIPB2_HUMAN;tr|H0YET1|H0YET1_HUMAN;tr|E9PIK8|E9PIK8_HUMAN;tr|H0YDJ2|H0YDJ2_HUMAN","tr|E9PP16|E9PP16_HUMAN;sp|Q8ND30|LIPB2_HUMAN",3312,"E9PP16","E9PP16_HUMAN",null,null,"PPFIBP2"]
["18.6651","18.97","19.7947","18.1135",{"$nulls":4},"chloride channel activity","chloride channel complex;endoplasmic reticulum;Golgi apparatus;intracellular membrane-bounded organelle;membrane;nucleus",{"$nulls":3},5,5,5,"12.9","12.9","12.9","62.022",0,"40.805",203250000,25,"0.0517436",1,"-0.136569","-0.159856","sp|Q96S66|CLCC1_HUMAN","sp|Q96S66|CLCC1_HUMAN",3815,"Q96S66","CLCC1_HUMAN","Chloride channel CLIC-like protein 1",null,"CLCC1"]
["16.4895","17.0065","16.6621","17.1091",{"$nulls":3},"axon guidance;heart development;Roundabout signaling pathway",null,"plasma membrane",{"$nulls":3},21,19,19,"21.7","20.2","20.2","175.85",0,"80.938",341360000,56,"0.138986",1,"-0.137621","-0.40271","tr|A0A087WTM1|A0A087WTM1_HUMAN;sp|Q9Y6N7|ROBO1_HUMAN;tr|A0A087WZ85|A0A087WZ85_HUMAN;tr|A0A0A0MSX4|A0A0A0MSX4_HUMAN;tr|H7C4Y7|H7C4Y7_HUMAN;tr|H7C545|H7C545_HUMAN","tr|A0A087WTM1|A0A087WTM1_HUMAN;sp|Q9Y6N7|ROBO1_HUMAN;tr|A0A087WZ85|A0A087WZ85_HUMAN;tr|A0A0A0MSX4|A0A0A0MSX4_HUMAN",5110,"A0A087WTM1","A0A087WTM1_HUMAN",null,null,"ROBO1"]
["18.3018","19.78","18.7159","19.6448",{"$nulls":3},"carbohydrate metabolic process","phosphotransferase activity, alcohol group as acceptor",null,"Metabolic pathways",null,null,6,6,6,"21.3","21.3","21.3","51.504",0,"22.977",118150000,13,"0.0516865",1,"-0.139392","-0.159688","tr|A0A0B4J2A0|A0A0B4J2A0_HUMAN;sp|Q9UHJ6|SHPK_HUMAN","tr|A0A0B4J2A0|A0A0B4J2A0_HUMAN;sp|Q9UHJ6|SHPK_HUMAN",4727,"A0A0B4J2A0","A0A0B4J2A0_HUMAN"]
["16.5893","19.1779","16.8129","19.2341",{"$nulls":3},"protein homotetramerization;tRNA modification;tRNA processing","ATP binding;GTP binding;identical protein binding;magnesium ion binding;nucleotidyltransferase activity;tRNA binding;tRNA guanylyltransferase activity","cytosol;mitochondrion",{"$nulls":3},2,2,2,7,7,7,"34.83","0.0002412","5.6061",53876000,7,"0.024904",1,"-0.139894","-0.0789372","sp|Q9NWX6|THG1_HUMAN","sp|Q9NWX6|THG1_HUMAN",4525,"Q9NWX6","THG1_HUMAN","Probable tRNA(His) guanylyltransferase",null,"THG1L"]
["18.7942",1,"19.075",1,{"$nulls":3},"apoptotic process;multicellular organismal lipid catabolic process;negative regulation of peptidyl-lysine acetylation;steroid biosynthetic process","hydrolase activity;nucleotide binding","mitochondrion;nucleolus",{"$nulls":3},1,1,1,"9.8","9.8","9.8","17.162",0,"10.277",24292000,2,"0.00341318",1,"-0.140407","-0.0110713","sp|Q9BX68|HINT2_HUMAN","sp|Q9BX68|HINT2_HUMAN",4038,"Q9BX68","HINT2_HUMAN","Histidine triad nucleotide-binding protein 2, mitochondrial","INT-2","HINT2"]
["20.4903","20.7881","20.9976","20.5633",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;cell division;ER to Golgi vesicle-mediated transport;microtubule cytoskeleton organization;microtubule-based movement;neutrophil degranulation;positive regulation of mitotic cell cycle spindle assembly checkpoint;sister chromatid cohesion;viral process","ATP binding;dynein heavy chain binding;GDP binding;microtubule motor activity;RNA binding","centrosome;condensed chromosome kinetochore;cytoplasmic dynein complex;cytosol;ficolin-1-rich granule membrane;kinetochore;membrane;microtubule;plasma membrane;secretory granule membrane;spindle pole","Phagosome;Salmonella infection;Vasopressin-regulated water reabsorption",null,null,12,12,12,"35.2","35.2","35.2","56.578",0,"73.106",434460000,58,"0.190181",1,"-0.14123","-0.536356","sp|Q9Y6G9|DC1L1_HUMAN;tr|E9PHI6|E9PHI6_HUMAN;tr|C9JGM7|C9JGM7_HUMAN;tr|C9JLW1|C9JLW1_HUMAN","sp|Q9Y6G9|DC1L1_HUMAN;tr|E9PHI6|E9PHI6_HUMAN",5094,"Q9Y6G9","DC1L1_HUMAN","Cytoplasmic dynein 1 light intermediate chain 1","IC1","DYNC1LI1"]
["22.7332","22.9487","23.2519","22.714",{"$nulls":3},"intracellular cholesterol transport",null,"intracellular",{"$nulls":3},7,7,7,"56.1","56.1","56.1","16.23",0,"21.921",604430000,34,"0.172231",1,"-0.141959","-0.48999","tr|J3KMY5|J3KMY5_HUMAN;sp|P61916|NPC2_HUMAN;tr|G3V3E8|G3V3E8_HUMAN;tr|E7EMS2|E7EMS2_HUMAN;tr|G3V3D1|G3V3D1_HUMAN;tr|H0YIZ1|H0YIZ1_HUMAN;tr|G3V2V8|G3V2V8_HUMAN","tr|J3KMY5|J3KMY5_HUMAN;sp|P61916|NPC2_HUMAN;tr|G3V3E8|G3V3E8_HUMAN;tr|E7EMS2|E7EMS2_HUMAN;tr|G3V3D1|G3V3D1_HUMAN;tr|H0YIZ1|H0YIZ1_HUMAN;tr|G3V2V8|G3V2V8_HUMAN",1857,"J3KMY5","J3KMY5_HUMAN",null,null,"NPC2"]
["19.9496","18.6655","19.7632","19.1384",{"$nulls":3},"covalent chromatin modification;regulation of transcription, DNA-templated;transcription, DNA-templated",null,"nuclear speck",{"$nulls":3},12,12,9,"43.7","43.7","32.5","40.028",0,"35.966",571820000,69,"0.0657414",1,"-0.143273","-0.200651","tr|B3KTM8|B3KTM8_HUMAN;tr|H0YLJ3|H0YLJ3_HUMAN;sp|Q9UBU8|MO4L1_HUMAN;tr|H0YMJ0|H0YMJ0_HUMAN;tr|H0YM21|H0YM21_HUMAN;tr|H0YLV1|H0YLV1_HUMAN;tr|H0YMT8|H0YMT8_HUMAN;tr|H0YNE0|H0YNE0_HUMAN;tr|H0YNX3|H0YNX3_HUMAN;tr|H0YNI8|H0YNI8_HUMAN","tr|B3KTM8|B3KTM8_HUMAN;tr|H0YLJ3|H0YLJ3_HUMAN;sp|Q9UBU8|MO4L1_HUMAN;tr|H0YMJ0|H0YMJ0_HUMAN;tr|H0YM21|H0YM21_HUMAN;tr|H0YLV1|H0YLV1_HUMAN;tr|H0YMT8|H0YMT8_HUMAN;tr|H0YNE0|H0YNE0_HUMAN",5171,"B3KTM8","B3KTM8_HUMAN",null,null,"MORF4L1"]
["17.6155",1,"17.9032",1,{"$nulls":9},2,2,2,5,5,5,"59.256","0.00025094","6.4364",34933000,5,"0.00374369",1,"-0.143858","-0.0121388","tr|A0A0A0MSJ8|A0A0A0MSJ8_HUMAN;tr|T1ECW5|T1ECW5_HUMAN;sp|O75170|PP6R2_HUMAN","tr|A0A0A0MSJ8|A0A0A0MSJ8_HUMAN;tr|T1ECW5|T1ECW5_HUMAN;sp|O75170|PP6R2_HUMAN",534,"A0A0A0MSJ8","A0A0A0MSJ8_HUMAN",null,null,"PPP6R2"]
["19.7121","20.8989","20.3083","20.5912",{"$nulls":3},"cellular response to DNA damage stimulus;ribosome biogenesis;signal transduction;T cell mediated immunity","GTP binding;GTPase activity;structural molecule activity","extracellular space;nucleus",{"$nulls":3},10,10,10,"22.2","22.2","22.2","68.66",0,"101.41",338430000,24,"0.0782719",1,"-0.144246","-0.23647","sp|P36915|GNL1_HUMAN;tr|A2AB27|A2AB27_HUMAN","sp|P36915|GNL1_HUMAN;tr|A2AB27|A2AB27_HUMAN",1414,"P36915","GNL1_HUMAN","Guanine nucleotide-binding protein-like 1",null,"GNL1"]
["18.0935","17.7792","17.932","18.231",{"$nulls":3},"canonical Wnt signaling pathway;innate immune response;negative regulation of inflammatory response;negative regulation of NF-kappaB transcription factor activity;nucleotide-binding oligomerization domain containing 2 signaling pathway;protein linear deubiquitination;protein ubiquitination;regulation of tumor necrosis factor-mediated signaling pathway;sprouting angiogenesis","cysteine-type peptidase activity;thiol-dependent ubiquitin-specific protease activity","cytoplasm;cytosol;LUBAC complex",{"$nulls":3},3,3,3,"15.6","15.6","15.6","40.262","0.00024207","5.674",51749000,14,"0.242474",1,"-0.145179","-0.669397","sp|Q96BN8|OTUL_HUMAN;tr|H0Y9T0|H0Y9T0_HUMAN","sp|Q96BN8|OTUL_HUMAN",3615,"Q96BN8","OTUL_HUMAN","Ubiquitin thioesterase otulin {ECO:0000305}"]
["14.8222",1,"15.1129",1,{"$nulls":3},"Wnt signaling pathway",{"$nulls":5},2,2,2,"2.6","2.6","2.6","86.68","0.00069029","4.623",14238000,8,"0.00454281",1,"-0.145358","-0.0147167","tr|E7ES00|E7ES00_HUMAN;sp|Q9Y2T1|AXIN2_HUMAN","tr|E7ES00|E7ES00_HUMAN;sp|Q9Y2T1|AXIN2_HUMAN",4936,"E7ES00","E7ES00_HUMAN",null,null,"AXIN2"]
["23.248","21.2893","23.2166","21.6127",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;cellular response to nerve growth factor stimulus;ephrin receptor signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;membrane organization;movement of cell or subcellular component","actin binding;structural constituent of cytoskeleton","actin cytoskeleton;Arp2/3 protein complex;cytosol;extracellular exosome;filamentous actin;focal adhesion;growth cone leading edge;lamellipodium;membrane","Bacterial invasion of epithelial cells;Endocytosis;Fc gamma R-mediated phagocytosis;Pathogenic Escherichia coli infection;Regulation of actin cytoskeleton;Salmonella infection;Shigellosis",null,null,7,7,7,"45.5","45.5","45.5","20.546",0,"42.928",658800000,34,"0.0368112",1,"-0.145961","-0.115312","sp|O15145|ARPC3_HUMAN;tr|C9JZD1|C9JZD1_HUMAN;tr|F8VR50|F8VR50_HUMAN","sp|O15145|ARPC3_HUMAN",331,"O15145","ARPC3_HUMAN","Actin-related protein 2/3 complex subunit 3",null,"ARPC3"]
["17.4226","16.0969","16.5219","17.2915",{"$nulls":3},"cell cycle;cellular senescence;negative regulation of beta-galactosidase activity;negative regulation of cellular senescence;negative regulation of exonuclease activity;negative regulation of gene expression;negative regulation of t-circle formation;negative regulation of telomere capping;negative regulation of telomere maintenance;negative regulation of telomere maintenance via recombination;negative regulation of telomere maintenance via semi-conservative replication;negative regulation of telomere maintenance via telomerase;negative regulation of telomere maintenance via telomere lengthening;negative regulation of telomere single strand break repair;negative regulation of telomeric D-loop disassembly;positive regulation of gene expression;positive regulation of nitric-oxide synthase activity;protection from non-homologous end joining at telomere;protein localization to chromosome, telomeric region;regulation of telomere maintenance;regulation of telomere maintenance via telomerase;RNA-dependent DNA biosynthetic process;telomere capping;telomere maintenance;telomeric D-loop disassembly;telomeric loop formation","double-stranded telomeric DNA binding;enzyme binding;G-rich strand telomeric DNA binding;macromolecular complex binding;protein C-terminus binding;protein homodimerization activity;telomeric DNA binding","chromosome, telomeric region;nuclear body;nuclear chromosome, telomeric region;nuclear telomere cap complex;nucleoplasm;nucleus;shelterin complex",{"$nulls":3},7,7,7,"19.6","19.6","19.6","59.593",0,"17.515",85586000,14,"0.0626502",1,"-0.146935","-0.191716","sp|Q15554|TERF2_HUMAN;tr|U3KQ35|U3KQ35_HUMAN;tr|H3BR06|H3BR06_HUMAN;tr|J3KSZ6|J3KSZ6_HUMAN;tr|H3BTA7|H3BTA7_HUMAN;tr|V9GYM1|V9GYM1_HUMAN;tr|J3KSJ9|J3KSJ9_HUMAN","sp|Q15554|TERF2_HUMAN;tr|U3KQ35|U3KQ35_HUMAN;tr|H3BR06|H3BR06_HUMAN;tr|J3KSZ6|J3KSZ6_HUMAN",2499,"Q15554","TERF2_HUMAN","Telomeric repeat-binding factor 2",null,"TERF2"]
["23.1897","22.8606","23.4166","22.9285",{"$nulls":3},"glutathione metabolic process;hydrogen sulfide metabolic process;sulfide oxidation, using sulfide:quinone oxidoreductase","iron ion binding;sulfur dioxygenase activity","cytoplasm;mitochondrial matrix;mitochondrion;nucleoplasm","Metabolic pathways;Sulfur metabolism",null,null,8,8,8,"38.6","38.6","38.6","27.873",0,"58.487",1046900000,50,"0.17639",1,"-0.147409","-0.500774","sp|O95571|ETHE1_HUMAN;tr|M0QXB5|M0QXB5_HUMAN;tr|M0QY80|M0QY80_HUMAN;tr|M0QX80|M0QX80_HUMAN","sp|O95571|ETHE1_HUMAN;tr|M0QXB5|M0QXB5_HUMAN",744,"O95571","ETHE1_HUMAN","Persulfide dioxygenase ETHE1, mitochondrial",null,"ETHE1"]
["19.4121","18.3263","20.0231","18.0124",{"$nulls":3},"activation of protein kinase B activity;adherens junction organization;angiotensin-activated signaling pathway involved in heart process;axon guidance;bone resorption;branching involved in mammary gland duct morphogenesis;cell cycle;cell proliferation;cell-cell adhesion;cellular response to fatty acid;cellular response to fluid shear stress;cellular response to hypoxia;cellular response to insulin stimulus;cellular response to lipopolysaccharide;cellular response to peptide hormone stimulus;cellular response to platelet-derived growth factor stimulus;cellular response to progesterone stimulus;cellular response to reactive oxygen species;central nervous system development;entry of bacterium into host cell;ephrin receptor signaling pathway;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;Fc-gamma receptor signaling pathway involved in phagocytosis;forebrain development;innate immune response;integrin-mediated signaling pathway;intracellular estrogen receptor signaling pathway;intracellular signal transduction;leukocyte migration;macroautophagy;negative regulation of anoikis;negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of focal adhesion assembly;negative regulation of intrinsic apoptotic signaling pathway;negative regulation of mitochondrial depolarization;negative regulation of protein homooligomerization;negative regulation of telomerase activity;negative regulation of telomere maintenance via telomerase;negative regulation of transcription, DNA-templated;neurotrophin TRK receptor signaling pathway;oogenesis;osteoclast development;peptidyl-serine phosphorylation;peptidyl-tyrosine autophosphorylation;peptidyl-tyrosine phosphorylation;platelet activation;platelet-derived growth factor receptor signaling pathway;positive regulation of apoptotic process;positive regulation of canonical Wnt signaling pathway;positive regulation of cyclin-dependent protein serine/threonine kinase activity;positive regulation of cytokine secretion;positive regulation of DNA biosynthetic process;positive regulation of epithelial cell migration;positive regulation of ERK1 and ERK2 cascade;positive regulation of glucose metabolic process;positive regulation of insulin receptor signaling pathway;positive regulation of integrin activation;positive regulation of lamellipodium morphogenesis;positive regulation of MAP kinase activity;positive regulation of ovarian follicle development;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of phosphatidylinositol 3-kinase activity;positive regulation of platelet-derived growth factor receptor signaling pathway;positive regulation of podosome assembly;positive regulation of protein autophosphorylation;positive regulation of protein kinase B signaling;positive regulation of protein localization to nucleus;positive regulation of protein processing;positive regulation of protein serine/threonine kinase activity;positive regulation of small GTPase mediated signal transduction;positive regulation of smooth muscle cell migration;positive regulation of transcription, DNA-templated;primary ovarian follicle growth;progesterone receptor signaling pathway;protein autophosphorylation;protein destabilization;regulation of bone resorption;regulation of caveolin-mediated endocytosis;regulation of cell cycle;regulation of cell projection assembly;regulation of cell proliferation;regulation of cell-cell adhesion;regulation of early endosome to late endosome transport;regulation of epithelial cell migration;regulation of intracellular estrogen receptor signaling pathway;regulation of podosome assembly;regulation of protein binding;regulation of vascular permeability;response to acidic pH;response to drug;response to electrical stimulus;response to hydrogen peroxide;response to interleukin-1;response to mechanical stimulus;response to mineralocorticoid;response to nutrient levels;response to virus;signal complex assembly;signal transduction;stimulatory C-type lectin receptor signaling pathway;stress fiber assembly;substrate adhesion-dependent cell spreading;T cell costimulation;transcytosis;transforming growth factor beta receptor signaling pathway;uterus development;vascular endothelial growth factor receptor signaling pathway;viral process","ATP binding;cadherin binding;connexin binding;enzyme binding;ephrin receptor binding;estrogen receptor binding;growth factor receptor binding;heme binding;hormone receptor binding;insulin receptor binding;integrin binding;ion channel binding;kinase activity;kinase binding;non-membrane spanning protein tyrosine kinase activity;phosphoprotein binding;protein C-terminus binding;protein kinase activity;protein kinase C binding;protein tyrosine kinase activity;receptor binding;scaffold protein binding;SH2 domain binding;SH3/SH2 adaptor activity;ubiquitin protein ligase binding","actin filament;caveola;cytoplasm;cytosol;extracellular exosome;extrinsic component of cytoplasmic side of plasma membrane;late endosome;lysosome;mitochondrial inner membrane;mitochondrion;neuron projection;nucleoplasm;perinuclear region of cytoplasm;plasma membrane;podosome;postsynaptic density;ruffle membrane","Adherens junction;Axon guidance;Bacterial invasion of epithelial cells;Bladder cancer;Chemokine signaling pathway;C-type lectin receptor signaling pathway;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endocytosis;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;GABAergic synapse;Gap junction;GnRH signaling pathway;Hepatitis B;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Inflammatory mediator regulation of TRP channels;Kaposi sarcoma-associated herpesvirus infection;Mitophagy - animal;Oxytocin signaling pathway;Platelet activation;Prolactin signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Shigellosis;Thyroid hormone signaling pathway;Tight junction;Tuberculosis;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,4,4,3,"9.5","9.5","7.6","59.834",0,"20.945",172480000,16,"0.0416904",1,"-0.148524","-0.129992","sp|P12931|SRC_HUMAN;sp|P07947|YES_HUMAN;tr|J3QRU1|J3QRU1_HUMAN;sp|P06241|FYN_HUMAN","sp|P12931|SRC_HUMAN;sp|P07947|YES_HUMAN;tr|J3QRU1|J3QRU1_HUMAN",1017,"P12931","SRC_HUMAN","Proto-oncogene tyrosine-protein kinase Src",null,"SRC"]
["18.0318","18.9035","18.4361","18.7968",{"$nulls":3},"endocytosis;protein transport",null,"clathrin vesicle coat;clathrin-coated pit;intracellular;plasma membrane",{"$nulls":3},3,3,3,"22.4","22.4","22.4","28.338","0.00025126","6.4595",46013000,5,"0.106678",1,"-0.148853","-0.31558","sp|Q9NVZ3|NECP2_HUMAN;tr|D6RAN6|D6RAN6_HUMAN;tr|F6SKB8|F6SKB8_HUMAN;tr|H0Y970|H0Y970_HUMAN;tr|D6RB24|D6RB24_HUMAN","sp|Q9NVZ3|NECP2_HUMAN;tr|D6RAN6|D6RAN6_HUMAN;tr|F6SKB8|F6SKB8_HUMAN",4507,"Q9NVZ3","NECP2_HUMAN","Adaptin ear-binding coat-associated protein 2",null,"NECAP2"]
["20.2464","21.7371","20.9106","21.3742",{"$nulls":3},"mitochondrial respiratory chain complex I assembly","calmodulin binding","mitochondrial inner membrane;mitochondrial membrane;mitochondrion","Thermogenesis",null,null,5,5,5,"29.1","29.1","29.1","20.266",0,"11.837",253960000,12,"0.0630709",1,"-0.150595","-0.192935","sp|Q9P032|NDUF4_HUMAN","sp|Q9P032|NDUF4_HUMAN",4612,"Q9P032","NDUF4_HUMAN","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4",null,"NDUFAF4"]
["16.6639",1,"16.9676",1,{"$nulls":9},3,3,3,"13.9","13.9","13.9","29.484","0.0015093","3.6349",19592000,4,"0.00418982",1,"-0.151861","-0.0135785","tr|Q4VXZ8|Q4VXZ8_HUMAN;sp|Q9NUI1|DECR2_HUMAN;tr|A0A0J9YWI0|A0A0J9YWI0_HUMAN","tr|Q4VXZ8|Q4VXZ8_HUMAN;sp|Q9NUI1|DECR2_HUMAN",4461,"Q4VXZ8","Q4VXZ8_HUMAN",null,null,"DECR2"]
["20.3751","16.7414","20.3795","17.0409",{"$nulls":3},"response to oxidative stress","glutathione peroxidase activity","cytosol",{"$nulls":3},3,3,3,"19.3","19.3","19.3","21.938",0,"10.323",93442000,15,"0.019323",1,"-0.151989","-0.0616013","tr|A0A087WUQ6|A0A087WUQ6_HUMAN;sp|P07203|GPX1_HUMAN","tr|A0A087WUQ6|A0A087WUQ6_HUMAN;sp|P07203|GPX1_HUMAN",892,"A0A087WUQ6","A0A087WUQ6_HUMAN","Glutathione peroxidase {ECO:0000256|RuleBase:RU000499}",null,"GPX1"]
["22.569","22.169","22.9481","22.0975",{"$nulls":3},"cellular iron ion homeostasis;citrate metabolic process;intestinal absorption;post-embryonic development;regulation of translation;response to iron(II) ion;tricarboxylic acid cycle","3 iron, 4 sulfur cluster binding;4 iron, 4 sulfur cluster binding;aconitate hydratase activity;iron-responsive element binding;metal ion binding;RNA binding","cytoplasm;cytosol;endoplasmic reticulum;extracellular exosome;Golgi apparatus;mitochondrion","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Metabolic pathways",null,null,30,30,30,"45.7","45.7","45.7","98.398",0,"258.71",2259600000,98,"0.110948",1,"-0.153796","-0.327253","sp|P21399|ACOC_HUMAN;tr|F5H2R8|F5H2R8_HUMAN;tr|F5H143|F5H143_HUMAN;tr|F5H3Z7|F5H3Z7_HUMAN;tr|E9PEF1|E9PEF1_HUMAN;sp|O00408|PDE2A_HUMAN","sp|P21399|ACOC_HUMAN",1166,"P21399","ACOC_HUMAN","Cytoplasmic aconitate hydratase","conitase","ACO1"]
["17.4422","18.2887","17.8197","18.2213",{"$nulls":9},4,4,4,"12.6","12.6","12.6","44.609",0,"15.974",57062000,15,"0.112317",1,"-0.155049","-0.330983","tr|J9JIC5|J9JIC5_HUMAN;sp|Q9HAS0|NJMU_HUMAN;tr|J3KRR1|J3KRR1_HUMAN;tr|J3QKQ1|J3QKQ1_HUMAN","tr|J9JIC5|J9JIC5_HUMAN;sp|Q9HAS0|NJMU_HUMAN;tr|J3KRR1|J3KRR1_HUMAN",4292,"J9JIC5","J9JIC5_HUMAN",null,null,"C17orf75"]
["21.3441","21.625","21.736","21.544",{"$nulls":3},"nucleobase-containing compound metabolic process;nucleotide biosynthetic process","enzyme inhibitor activity;identical protein binding;magnesium ion binding;ribose phosphate diphosphokinase activity",{"$nulls":4},10,9,9,"44.7","40.7","40.7","39.393",0,"72.624",463300000,19,"0.339785",1,"-0.155453","-0.913728","sp|Q14558|KPRA_HUMAN;tr|B4DP31|B4DP31_HUMAN;tr|C9J168|C9J168_HUMAN;tr|C9JNQ3|C9JNQ3_HUMAN;tr|C9JUN4|C9JUN4_HUMAN;tr|C9JKT9|C9JKT9_HUMAN","sp|Q14558|KPRA_HUMAN;tr|B4DP31|B4DP31_HUMAN;tr|C9J168|C9J168_HUMAN",2369,"Q14558","KPRA_HUMAN","Phosphoribosyl pyrophosphate synthase-associated protein 1","RPP synthase-associated protein 1","PRPSAP1"]
["25.1521","24.5407","25.3331","24.6727",{"$nulls":3},"fatty acid beta-oxidation","isomerase activity;receptor binding","extracellular exosome;membrane;mitochondrion;peroxisome","Peroxisome",null,null,10,8,8,"43.9","35.4","35.4","35.816",0,"323.31",5000700000,152,"0.118525",1,"-0.156511","-0.347841","sp|Q13011|ECH1_HUMAN;tr|M0R248|M0R248_HUMAN;tr|M0QZW4|M0QZW4_HUMAN;tr|M0QXS7|M0QXS7_HUMAN;tr|M0R1A2|M0R1A2_HUMAN","sp|Q13011|ECH1_HUMAN;tr|M0R248|M0R248_HUMAN",2193,"Q13011","ECH1_HUMAN","Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial",null,"ECH1"]
["16.1298","15.753","16.2797","15.9183",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;apoptotic process;clathrin coat assembly;clathrin-dependent endocytosis;digestive system development;membrane organization;negative regulation of actin filament polymerization;negative regulation of apoptotic process;negative regulation of Arp2/3 complex-mediated actin nucleation;positive regulation of apoptotic process;positive regulation of clathrin coat assembly;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;positive regulation of platelet-derived growth factor receptor-beta signaling pathway;positive regulation of protein binding;protein stabilization;receptor-mediated endocytosis;regulation of actin cytoskeleton organization;regulation of clathrin-dependent endocytosis;regulation of endocytosis;regulation of gastric acid secretion","actin filament binding;clathrin adaptor activity;clathrin binding;clathrin light chain binding;identical protein binding;phosphatidylinositol binding;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;phosphatidylinositol-3,5-bisphosphate binding;phosphatidylinositol-4,5-bisphosphate binding;protein heterodimerization activity;protein homodimerization activity;SH3 domain binding","apical plasma membrane;cell cortex;clathrin-coated pit;clathrin-coated vesicle;clathrin-coated vesicle membrane;cytoskeleton;cytosol;dendrite cytoplasm;dendritic spine;intracellular membrane-bounded organelle;mitochondrion;neuronal cell body;perinuclear region of cytoplasm;postsynaptic density;ruffle membrane;synaptic membrane",{"$nulls":3},6,5,5,"7.1","6.2","6.2","119.39",0,"10.955",53105000,11,"0.216545",1,"-0.157598","-0.603742","sp|O75146|HIP1R_HUMAN","sp|O75146|HIP1R_HUMAN",527,"O75146","HIP1R_HUMAN","Huntingtin-interacting protein 1-related protein","IP1-related protein","HIP1R"]
[1,"17.6497",1,"17.9668",{"$nulls":9},1,1,1,"3.2","3.2","3.2","54.704","0.0087024","2.2918",25892000,5,"0.00411583",1,"-0.158554","-0.0133398","tr|Q5T8C6|Q5T8C6_HUMAN;sp|Q13042|CDC16_HUMAN","tr|Q5T8C6|Q5T8C6_HUMAN;sp|Q13042|CDC16_HUMAN",2196,"Q5T8C6","Q5T8C6_HUMAN",null,null,"CDC16"]
["22.4316","22.9978","22.6263","23.1211",{"$nulls":3},"DNA repair;establishment of mitotic spindle orientation;microtubule anchoring;microtubule cytoskeleton organization;mitotic spindle assembly;mitotic spindle organization;neuroendocrine cell differentiation;regulation of cyclin-dependent protein serine/threonine kinase activity","kinase regulator activity;RNA binding;tubulin binding","centriole;centrosome;cytosol;mitotic spindle pole;nuclear cyclin-dependent protein kinase holoenzyme complex;nucleoplasm;nucleus",{"$nulls":3},7,7,7,"26.4","26.4","26.4","35.979",0,"121.91",1275500000,46,"0.146589",1,"-0.158979","-0.422855","sp|Q9P287|BCCIP_HUMAN","sp|Q9P287|BCCIP_HUMAN",4635,"Q9P287","BCCIP_HUMAN","BRCA2 and CDKN1A-interacting protein",null,"BCCIP"]
["19.5996",1,"19.9186",1,{"$nulls":3},"cellular sphingolipid homeostasis;ceramide metabolic process",null,"endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},2,1,1,"20.2","11.6","11.6","14.788","0.00023964","5.4686",42222000,9,"0.00370818",1,"-0.159502","-0.0120241","tr|J3QRM9|J3QRM9_HUMAN;sp|Q8N138|ORML3_HUMAN;tr|J3KTF9|J3KTF9_HUMAN;tr|F8VXD5|F8VXD5_HUMAN","tr|J3QRM9|J3QRM9_HUMAN;sp|Q8N138|ORML3_HUMAN;tr|J3KTF9|J3KTF9_HUMAN;tr|F8VXD5|F8VXD5_HUMAN",3194,"J3QRM9","J3QRM9_HUMAN",null,null,"ORMDL3"]
["23.189","22.8405","23.1468","23.204",{"$nulls":3},"cell redox homeostasis;protein folding;response to endoplasmic reticulum stress","disulfide oxidoreductase activity;protein disulfide isomerase activity","endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},9,9,9,"32.9","32.9","32.9","31.791",0,"42.285",779150000,36,"0.338241",1,"-0.160654","-0.909847","sp|Q9H3N1|TMX1_HUMAN;tr|G3V448|G3V448_HUMAN","sp|Q9H3N1|TMX1_HUMAN",4190,"Q9H3N1","TMX1_HUMAN","Thioredoxin-related transmembrane protein 1",null,"TMX1"]
["15.1532","14.9485","15.4037","15.0212",{"$nulls":3},"apoptotic process;blood coagulation;cell migration;cytoskeleton organization;Fc-gamma receptor signaling pathway involved in phagocytosis;integrin-mediated signaling pathway;phagocytosis, engulfment;positive regulation of epithelial cell migration;positive regulation of substrate adhesion-dependent cell spreading;signal transduction;small GTPase mediated signal transduction;vascular endothelial growth factor receptor signaling pathway","GTPase activator activity;Rho guanyl-nucleotide exchange factor activity;SH3 domain binding","cytoplasm;cytosol;guanyl-nucleotide exchange factor complex;membrane","Bacterial invasion of epithelial cells;Focal adhesion;Regulation of actin cytoskeleton;Shigellosis;Yersinia infection",null,null,11,11,10,"6.8","6.8","6.2","215.34",0,"15.207",113590000,19,"0.272506",1,"-0.161599","-0.744958","sp|Q14185|DOCK1_HUMAN;tr|A0A096LNH6|A0A096LNH6_HUMAN","sp|Q14185|DOCK1_HUMAN;tr|A0A096LNH6|A0A096LNH6_HUMAN",2343,"Q14185","DOCK1_HUMAN","Dedicator of cytokinesis protein 1",null,"DOCK1"]
["20.9326","19.8632","20.993","20.1272",{"$nulls":3},"androgen receptor signaling pathway;brain development;ovarian follicle development;positive regulation of phosphatidylinositol 3-kinase signaling;positive regulation of protein ubiquitination;positive regulation of transcription from RNA polymerase II promoter;progesterone receptor signaling pathway;prostate gland growth;protein autoubiquitination;protein K48-linked ubiquitination;proteolysis;regulation of circadian rhythm;regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;response to progesterone;sperm entry;ubiquitin-dependent protein catabolic process;viral process","metal ion binding;transcription coactivator activity;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;nucleus;proteasome complex","Human papillomavirus infection;Ubiquitin mediated proteolysis;Viral carcinogenesis",null,null,19,19,19,"24.5","24.5","24.5","100.69",0,"123.7",586680000,63,"0.0780253",1,"-0.162207","-0.235771","sp|Q05086|UBE3A_HUMAN;tr|A0A0D9SG77|A0A0D9SG77_HUMAN;tr|A0A0D9SGI3|A0A0D9SGI3_HUMAN;tr|A0A0D9SF91|A0A0D9SF91_HUMAN;tr|A0A0D9SES7|A0A0D9SES7_HUMAN;tr|A0A0D9SEJ2|A0A0D9SEJ2_HUMAN;tr|A0A0D9SG54|A0A0D9SG54_HUMAN;tr|A0A0D9SG63|A0A0D9SG63_HUMAN;tr|S4R306|S4R306_HUMAN","sp|Q05086|UBE3A_HUMAN;tr|A0A0D9SG77|A0A0D9SG77_HUMAN",2100,"Q05086","UBE3A_HUMAN","Ubiquitin-protein ligase E3A",null,"UBE3A"]
["22.5157","23.0422","22.6107","23.2727",{"$nulls":3},"rRNA processing;rRNA transcription","RNA binding","actin cytoskeleton;cytosol;nucleolus",{"$nulls":3},2,2,2,"17.4","17.4","17.4","19.343",0,"76.737",526180000,7,"0.132229",1,"-0.162702","-0.3847","sp|O75607|NPM3_HUMAN","sp|O75607|NPM3_HUMAN",592,"O75607","NPM3_HUMAN","Nucleoplasmin-3",null,"NPM3"]
["22.0616","21.428","22.2145","21.6052",{"$nulls":3},"nervous system development;positive regulation of protein dephosphorylation;protein dephosphorylation;signal transduction","phosphoprotein phosphatase activity;protein phosphatase regulator activity;protein serine/threonine phosphatase activity","cytosol;nucleoplasm;nucleus;protein phosphatase type 2A complex","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Dopaminergic synapse;Human papillomavirus infection;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway",null,null,20,20,17,"44.7","44.7","39.4","69.991",0,"99.536",1862700000,176,"0.128739",1,"-0.164974","-0.375355","sp|Q14738|2A5D_HUMAN;tr|E9PFR3|E9PFR3_HUMAN;tr|H0Y8C4|H0Y8C4_HUMAN;tr|H7C5Q9|H7C5Q9_HUMAN;tr|H0YN84|H0YN84_HUMAN;tr|H0YJ49|H0YJ49_HUMAN;tr|H0YJ35|H0YJ35_HUMAN","sp|Q14738|2A5D_HUMAN;tr|E9PFR3|E9PFR3_HUMAN;tr|H0Y8C4|H0Y8C4_HUMAN",2391,"Q14738","2A5D_HUMAN","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform",null,"PPP2R5D"]
["18.8551","18.5843","19.165","18.6048",{"$nulls":4},"actin binding;ATP binding;motor activity","myosin complex",{"$nulls":3},27,27,2,"23.9","23.9","1.4","149.63",0,"192.16",889970000,96,"0.188116",1,"-0.165201","-0.531045","tr|A0A0D9SGC1|A0A0D9SGC1_HUMAN;sp|Q9UM54|MYO6_HUMAN;tr|E7EW20|E7EW20_HUMAN;tr|Q5JVM0|Q5JVM0_HUMAN","tr|A0A0D9SGC1|A0A0D9SGC1_HUMAN;sp|Q9UM54|MYO6_HUMAN;tr|E7EW20|E7EW20_HUMAN",5156,"A0A0D9SGC1","A0A0D9SGC1_HUMAN",null,null,"MYO6"]
["20.5618","19.824","20.639","20.0802",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination;regulation of translation","ribosomal small subunit binding;RNA binding;rRNA binding","cytosol;mitochondrial inner membrane;mitochondrion;nucleoplasm;plasma membrane;ribosome",{"$nulls":3},9,9,9,"17.3","17.3","17.3","78.549",0,"34.592",503040000,50,"0.123094",1,"-0.166675","-0.360182","sp|Q96EY7|PTCD3_HUMAN;tr|B8ZZQ4|B8ZZQ4_HUMAN;tr|F8WE76|F8WE76_HUMAN","sp|Q96EY7|PTCD3_HUMAN",3677,"Q96EY7","PTCD3_HUMAN","Pentatricopeptide repeat domain-containing protein 3, mitochondrial",null,"PTCD3"]
["22.3495","22.0871","22.7387","22.0331",{"$nulls":3},"alternative mRNA splicing, via spliceosome;androgen receptor signaling pathway;defense response to virus;epithelial to mesenchymal transition;gene silencing by RNA;intracellular estrogen receptor signaling pathway;miRNA metabolic process;myoblast differentiation;positive regulation of transcription from RNA polymerase II promoter;regulation of alternative mRNA splicing, via spliceosome;regulation of skeletal muscle cell differentiation;regulation of transcription from RNA polymerase II promoter;RNA processing;RNA secondary structure unwinding;rRNA processing;transcription, DNA-templated","ATP binding;ATP-dependent RNA helicase activity;RNA binding;RNA helicase activity;RNA-dependent ATPase activity;transcription coactivator activity","cytoplasm;cytosol;membrane;nuclear speck;nucleolus;nucleoplasm;nucleus",{"$nulls":3},28,21,21,"44.6","34.4","34.4","80.272",0,"154.53",2013500000,132,"0.155076",1,"-0.167569","-0.445206","sp|Q92841|DDX17_HUMAN;tr|H3BLZ8|H3BLZ8_HUMAN","sp|Q92841|DDX17_HUMAN;tr|H3BLZ8|H3BLZ8_HUMAN",3541,"Q92841","DDX17_HUMAN","Probable ATP-dependent RNA helicase DDX17",null,"DDX17"]
["17.7187","18.2533","17.9916","18.3214",{"$nulls":9},2,2,2,"19.5","19.5","19.5","14.463","0.00025465","6.7621",74534000,11,"0.192751",1,"-0.170501","-0.542961","tr|K7ELB8|K7ELB8_HUMAN;sp|Q96S99|PKHF1_HUMAN;tr|K7EIX0|K7EIX0_HUMAN","tr|K7ELB8|K7ELB8_HUMAN;sp|Q96S99|PKHF1_HUMAN;tr|K7EIX0|K7EIX0_HUMAN",3817,"K7ELB8","K7ELB8_HUMAN",null,null,"PLEKHF1"]
["21.1526","21.3703","21.5455","21.3206",{"$nulls":3},"response to virus;RNA processing",null,"nucleoplasm",{"$nulls":3},16,16,16,"28.5","28.5","28.5","85.939",0,"94.258",887420000,73,"0.411979",1,"-0.171592","-1.09645","tr|A0A0A0MRA5|A0A0A0MRA5_HUMAN;tr|B7Z4B8|B7Z4B8_HUMAN;sp|Q9BUJ2|HNRL1_HUMAN;tr|M0R3F1|M0R3F1_HUMAN;tr|M0QYZ0|M0QYZ0_HUMAN;tr|M0QYI8|M0QYI8_HUMAN;tr|M0QYM5|M0QYM5_HUMAN;tr|M0R0K8|M0R0K8_HUMAN;tr|M0R203|M0R203_HUMAN;tr|M0QZV6|M0QZV6_HUMAN","tr|A0A0A0MRA5|A0A0A0MRA5_HUMAN;tr|B7Z4B8|B7Z4B8_HUMAN;sp|Q9BUJ2|HNRL1_HUMAN;tr|M0R3F1|M0R3F1_HUMAN;tr|M0QYZ0|M0QYZ0_HUMAN",3986,"A0A0A0MRA5","A0A0A0MRA5_HUMAN",null,null,"HNRNPUL1"]
["20.4017","19.7369","20.4219","20.0608",{"$nulls":3},"FAD biosynthetic process;oxidation-reduction process;riboflavin metabolic process","ATP binding;FMN adenylyltransferase activity","cytoplasm;cytosol;mitochondrial matrix;plasma membrane","Metabolic pathways;Riboflavin metabolism",null,null,10,10,10,"21.8","21.8","21.8","65.265",0,"45.179",368300000,30,"0.158785",1,"-0.17209","-0.454932","sp|Q8NFF5|FAD1_HUMAN;tr|Q5T196|Q5T196_HUMAN;tr|Q5T191|Q5T191_HUMAN;tr|Q5T190|Q5T190_HUMAN","sp|Q8NFF5|FAD1_HUMAN;tr|Q5T196|Q5T196_HUMAN",3337,"Q8NFF5","FAD1_HUMAN","FAD synthase",null,"FLAD1"]
["20.0542","19.983","20.434","19.9486",{"$nulls":3},"defense response to virus;innate immune response;negative regulation of viral genome replication;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha production;positive regulation of interferon-beta production;positive regulation of mRNA catabolic process;positive regulation of RIG-I signaling pathway;response to virus","cadherin binding;metal ion binding;RNA binding","cytoplasm;cytosol;nucleus",{"$nulls":3},17,17,17,"28.2","28.2","28.2","101.43",0,"106.04",572730000,63,"0.25629",1,"-0.172727","-0.704207","sp|Q7Z2W4|ZCCHV_HUMAN;tr|C9J6P4|C9J6P4_HUMAN;tr|H7C5K1|H7C5K1_HUMAN","sp|Q7Z2W4|ZCCHV_HUMAN;tr|C9J6P4|C9J6P4_HUMAN",2986,"Q7Z2W4","ZCCHV_HUMAN","Zinc finger CCCH-type antiviral protein 1",null,"ZC3HAV1"]
["19.3342","19.9755","19.6558","20.0002",{"$nulls":3},"cellular calcium ion homeostasis;cholesterol homeostasis;dephosphorylation;drug metabolic process;epoxide metabolic process;epoxygenase P450 pathway;inflammatory response;phospholipid dephosphorylation;positive regulation of blood vessel diameter;positive regulation of gene expression;reactive oxygen species metabolic process;regulation of blood pressure;regulation of cholesterol metabolic process;response to toxic substance;stilbene catabolic process;xenobiotic metabolic process","10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity;epoxide hydrolase activity;lipid phosphatase activity;magnesium ion binding;phosphatase activity;protein homodimerization activity;receptor binding;toxic substance binding","cytosol;extracellular exosome;peroxisome","Arachidonic acid metabolism;Metabolic pathways;Peroxisome",null,null,8,8,8,"25.8","25.8","25.8","62.615",0,"26.338",199810000,20,"0.166763",1,"-0.173158","-0.47577","sp|P34913|HYES_HUMAN;tr|E5RFU2|E5RFU2_HUMAN;tr|E5RFH6|E5RFH6_HUMAN;tr|H0YAW7|H0YAW7_HUMAN;tr|E5RI53|E5RI53_HUMAN","sp|P34913|HYES_HUMAN;tr|E5RFU2|E5RFU2_HUMAN;tr|E5RFH6|E5RFH6_HUMAN",1366,"P34913","HYES_HUMAN","Bifunctional epoxide hydrolase 2",null,"EPHX2"]
["14.8669","15.4006","15.5969","15.018",{"$nulls":3},"negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA catabolic process;protein transport;retrograde vesicle-mediated transport, Golgi to ER","SNARE binding","cytosol;Dsl1/NZR complex;endoplasmic reticulum;endoplasmic reticulum membrane;membrane",{"$nulls":3},6,6,6,"3.1","3.1","3.1","268.57",0,"9.6164",41122000,8,"0.153517",1,"-0.173671","-0.441111","sp|A2RRP1|NBAS_HUMAN;tr|H0Y5G7|H0Y5G7_HUMAN;tr|H7BZU5|H7BZU5_HUMAN;tr|H7C1Y9|H7C1Y9_HUMAN;tr|H7BZR3|H7BZR3_HUMAN;tr|C9JCM7|C9JCM7_HUMAN","sp|A2RRP1|NBAS_HUMAN;tr|H0Y5G7|H0Y5G7_HUMAN",157,"A2RRP1","NBAS_HUMAN","Neuroblastoma-amplified sequence",null,"NBAS"]
["21.3187","20.7548","21.3805","21.0415",{"$nulls":3},"mRNA 3'-splice site recognition;mRNA processing;mRNA splicing, via spliceosome;positive regulation of neuron projection development;RNA splicing","RNA binding;zinc ion binding","catalytic step 2 spliceosome;nuclear speck;nucleoplasm;small nuclear ribonucleoprotein complex;spliceosomal complex;U2 snRNP;U2-type prespliceosome","Spliceosome",null,null,5,5,5,17,17,17,"49.255",0,"31.552",343410000,20,"0.187546",1,"-0.174223","-0.529579","sp|Q15428|SF3A2_HUMAN;tr|K7EMT0|K7EMT0_HUMAN","sp|Q15428|SF3A2_HUMAN",2490,"Q15428","SF3A2_HUMAN","Splicing factor 3A subunit 2",null,"SF3A2"]
["22.8896","22.8439","23.1486","22.9342",{"$nulls":3},"positive regulation of cell proliferation;positive regulation of gene expression;protein methylation;tRNA splicing, via endonucleolytic cleavage and ligation","identical protein binding;protein methyltransferase activity;RNA binding","cytoplasm;intracellular membrane-bounded organelle;nucleoplasm;nucleus;tRNA-splicing ligase complex",{"$nulls":3},9,9,8,"38.8","38.8","34.5","37.19",0,"202.79",1077000000,70,"0.598618",1,"-0.174692","-1.5939","sp|Q52LJ0|FA98B_HUMAN;tr|H0YNA1|H0YNA1_HUMAN","sp|Q52LJ0|FA98B_HUMAN",2640,"Q52LJ0","FA98B_HUMAN","Protein FAM98B",null,"FAM98B"]
["21.8514","22.0011","21.9891","22.2147",{"$nulls":5},"mitochondrion",{"$nulls":3},8,6,6,"39.4","32.3","32.3","30.376",0,"65.009",530120000,28,"0.489656",1,"-0.175653","-1.29787","tr|A0A096LPI6|A0A096LPI6_HUMAN;tr|A0A0B4J2D5|A0A0B4J2D5_HUMAN;sp|P30042|ES1_HUMAN;tr|A0A096LNH5|A0A096LNH5_HUMAN;tr|H7C2G3|H7C2G3_HUMAN;tr|A0A0B4J2H4|A0A0B4J2H4_HUMAN;tr|H7C1F6|H7C1F6_HUMAN;tr|A0A096LP73|A0A096LP73_HUMAN;tr|F2Z2Q0|F2Z2Q0_HUMAN;tr|A0A096LP12|A0A096LP12_HUMAN;tr|A0A096LNJ1|A0A096LNJ1_HUMAN","tr|A0A096LPI6|A0A096LPI6_HUMAN;tr|A0A0B4J2D5|A0A0B4J2D5_HUMAN;sp|P30042|ES1_HUMAN;tr|A0A096LNH5|A0A096LNH5_HUMAN;tr|H7C2G3|H7C2G3_HUMAN;tr|A0A0B4J2H4|A0A0B4J2H4_HUMAN;tr|H7C1F6|H7C1F6_HUMAN;tr|A0A096LP73|A0A096LP73_HUMAN;tr|F2Z2Q0|F2Z2Q0_HUMAN;tr|A0A096LP12|A0A096LP12_HUMAN",5139,"A0A096LPI6","A0A096LPI6_HUMAN"]
["22.1889","22.4464","22.7397","22.248",{"$nulls":3},"cellular amino acid metabolic process;collagen catabolic process;proteolysis","aminopeptidase activity;manganese ion binding;metallocarboxypeptidase activity;proline dipeptidase activity","extracellular exosome",{"$nulls":3},13,13,13,"31.2","31.2","31.2","54.548",0,"159.01",1250500000,59,"0.228772",1,"-0.176156","-0.634765","sp|P12955|PEPD_HUMAN;tr|K7ES25|K7ES25_HUMAN;tr|V9GYL0|V9GYL0_HUMAN;tr|V9GYE4|V9GYE4_HUMAN","sp|P12955|PEPD_HUMAN",1018,"P12955","PEPD_HUMAN","Xaa-Pro dipeptidase",{"$f":"-Pro dipeptidase","v":{"$error":"#NAME?"}},"PEPD"]
["19.0378",1,"19.3927",1,{"$nulls":3},"RNA polymerase II complex import to nucleus;RNA polymerase III complex localization to nucleus","GTP binding;GTPase activity","cytosol;mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,"8.6","8.6","8.6","41.74","0.000257","6.9574",36813000,6,"0.00425135",1,"-0.177458","-0.013777","sp|Q9HCN4|GPN1_HUMAN;tr|F8WD09|F8WD09_HUMAN","sp|Q9HCN4|GPN1_HUMAN;tr|F8WD09|F8WD09_HUMAN",4333,"Q9HCN4","GPN1_HUMAN","GPN-loop GTPase 1 {ECO:0000303|PubMed:20855544}",null,"GPN1"]
["26.3424","26.5656","26.3558","26.9082",{"$nulls":3},"nuclear-transcribed mRNA poly(A) tail shortening;regulation of gene expression;RNA secondary structure unwinding;translational initiation;viral process","ATP binding;ATP-dependent RNA helicase activity;double-stranded RNA binding;helicase activity;mRNA binding;RNA binding;RNA cap binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 4F complex;extracellular exosome;extracellular matrix;membrane","RNA transport",null,null,29,29,18,"76.1","76.1","50.5","46.153",0,"323.31",19620000000,405,"0.21411",1,"-0.177989","-0.597548","sp|P60842|IF4A1_HUMAN;tr|J3KT12|J3KT12_HUMAN;tr|J3QS69|J3QS69_HUMAN;tr|J3KTB5|J3KTB5_HUMAN;tr|J3QL43|J3QL43_HUMAN;tr|J3QR64|J3QR64_HUMAN;tr|J3QLN6|J3QLN6_HUMAN;tr|J3KS25|J3KS25_HUMAN;tr|J3KSZ0|J3KSZ0_HUMAN;tr|J3QKZ9|J3QKZ9_HUMAN;tr|J3KTN0|J3KTN0_HUMAN;tr|J3KT04|J3KT04_HUMAN;tr|J3KS93|J3KS93_HUMAN;tr|J3QQP0|J3QQP0_HUMAN;tr|J3QL52|J3QL52_HUMAN","sp|P60842|IF4A1_HUMAN;tr|J3KT12|J3KT12_HUMAN;tr|J3QS69|J3QS69_HUMAN;tr|J3KTB5|J3KTB5_HUMAN;tr|J3QL43|J3QL43_HUMAN",1813,"P60842","IF4A1_HUMAN","Eukaryotic initiation factor 4A-I","IF4A-I;IF-4A-I","EIF4A1"]
["16.707","14.9521","16.8337","15.1834",{"$nulls":3},"cellular response to DNA damage stimulus;cellular response to hypoxia;DNA repair;mitotic G2 DNA damage checkpoint;negative regulation of phosphatidylinositol 3-kinase signaling;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of protein complex assembly;negative regulation of protein kinase B signaling;negative regulation of signal transduction by p53 class mediator;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein K63-linked deubiquitination;protein localization to nucleolus;protein localization to nucleoplasm;protein stabilization;regulation of aerobic respiration;regulation of apoptotic process;regulation of cell cycle;regulation of protein phosphorylation;regulation of RIG-I signaling pathway;regulation of signal transduction by p53 class mediator;ribosomal large subunit assembly;ribosomal large subunit export from nucleus","5S rRNA binding;identical protein binding;p53 binding;RNA binding","cytosol;fibrillar center;intracellular;intracellular membrane-bounded organelle;nucleolus;nucleoplasm",{"$nulls":3},4,4,4,13,13,13,"54.389",0,"8.8012",89187000,11,"0.0479272",1,"-0.178957","-0.148577","sp|Q9NZM5|GSCR2_HUMAN;tr|M0QZ34|M0QZ34_HUMAN;tr|M0QX73|M0QX73_HUMAN","sp|Q9NZM5|GSCR2_HUMAN",4600,"Q9NZM5","NOP53_HUMAN","Ribosome biogenesis protein NOP53 {ECO:0000305}",null,"NOP53"]
["19.5835","19.6097","20.057","19.4961",{"$nulls":3},"fatty acid beta-oxidation;fatty acid biosynthetic process;metabolic process","[acyl-carrier-protein] S-malonyltransferase activity;RNA binding;transferase activity","mitochondrial matrix;mitochondrion","Fatty acid biosynthesis;Fatty acid metabolism;Metabolic pathways",null,null,5,5,5,"18.7","18.7","18.7","42.961",0,"12.813",177210000,16,"0.231255",1,"-0.17996","-0.64105","sp|Q8IVS2|FABD_HUMAN","sp|Q8IVS2|FABD_HUMAN",3118,"Q8IVS2","FABD_HUMAN","Malonyl-CoA-acyl carrier protein transacylase, mitochondrial","CT","MCAT"]
["20.9764","20.3592","20.7751","20.9239",{"$nulls":5},"cytoplasm;microtubule organizing center;nucleoplasm","Glucagon signaling pathway",null,null,18,18,14,"31.3","31.3","26.5","95.367",0,118,592580000,57,"0.204245",1,"-0.181707","-0.572397","sp|Q6IN85|P4R3A_HUMAN;tr|G3V5Z3|G3V5Z3_HUMAN;tr|H0YIY8|H0YIY8_HUMAN;tr|G3V5A2|G3V5A2_HUMAN;tr|H0YJN6|H0YJN6_HUMAN","sp|Q6IN85|P4R3A_HUMAN;tr|G3V5Z3|G3V5Z3_HUMAN;tr|H0YIY8|H0YIY8_HUMAN",2822,"Q6IN85","P4R3A_HUMAN","Serine/threonine-protein phosphatase 4 regulatory subunit 3A {ECO:0000312|HGNC:HGNC:20219}",null,"PPP4R3A"]
["23.5135","23.6553","23.6708","23.8616",{"$nulls":3},"activation of MAPK activity;cell differentiation;Fc-epsilon receptor signaling pathway;JNK cascade;nucleotide-binding oligomerization domain containing signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription, DNA-templated;postreplication repair;protein K63-linked ubiquitination;protein polyubiquitination;regulation of DNA repair;regulation of transcription, DNA-templated;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway","ubiquitin protein ligase activity;ubiquitin protein ligase binding","cytoplasm;cytosol;extracellular exosome;nucleoplasm;nucleus;protein complex;UBC13-UEV1A complex;ubiquitin conjugating enzyme complex;ubiquitin ligase complex",{"$nulls":3},8,8,3,"63.3","63.3","25.2","16.495",0,"39.457",1150500000,57,"0.575254",1,"-0.181771","-1.5288","sp|Q13404|UB2V1_HUMAN;tr|I3L0A0|I3L0A0_HUMAN;tr|G3V2F7|G3V2F7_HUMAN;tr|A0A0A0MSL3|A0A0A0MSL3_HUMAN","sp|Q13404|UB2V1_HUMAN;tr|I3L0A0|I3L0A0_HUMAN;tr|G3V2F7|G3V2F7_HUMAN;tr|A0A0A0MSL3|A0A0A0MSL3_HUMAN",2244,"Q13404","UB2V1_HUMAN","Ubiquitin-conjugating enzyme E2 variant 1","EV-1","UBE2V1"]
["24.6642","25.4854","25.3691","25.146",{"$nulls":3},"actin cytoskeleton organization;actin filament branching;actin filament bundle assembly;actin filament organization;adherens junction organization;blood coagulation;canonical Wnt signaling pathway;cardiac conduction system development;Cdc42 protein signal transduction;cell junction assembly;cellular protein localization;cellular response to interferon-gamma;dendritic cell migration;dendritic spine morphogenesis;ephrin receptor signaling pathway;epithelial cell-cell adhesion;epithelial-mesenchymal cell signaling;establishment of epithelial cell apical/basal polarity;establishment of Golgi localization;establishment or maintenance of cell polarity;Fc-gamma receptor signaling pathway involved in phagocytosis;filopodium assembly;Golgi organization;hair follicle morphogenesis;hair follicle placode formation;heart contraction;integrin-mediated signaling pathway;interleukin-12-mediated signaling pathway;keratinization;keratinocyte development;macrophage differentiation;modification of synaptic structure;multicellular organism growth;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of gene expression;negative regulation of protein complex assembly;neuron fate determination;neuropilin signaling pathway;nuclear migration;organelle transport along microtubule;phagocytosis, engulfment;positive regulation of actin cytoskeleton reorganization;positive regulation of cell growth;positive regulation of cytokinesis;positive regulation of DNA replication;positive regulation of epithelial cell proliferation involved in lung morphogenesis;positive regulation of filopodium assembly;positive regulation of gene expression;positive regulation of hair follicle cell proliferation;positive regulation of intracellular protein transport;positive regulation of JNK cascade;positive regulation of lamellipodium assembly;positive regulation of muscle cell differentiation;positive regulation of neuron apoptotic process;positive regulation of peptidyl-serine phosphorylation;positive regulation of phosphatidylinositol 3-kinase activity;positive regulation of pseudopodium assembly;positive regulation of stress fiber assembly;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of synapse structural plasticity;regulation of attachment of spindle microtubules to kinetochore;regulation of filopodium assembly;regulation of lamellipodium assembly;regulation of mitotic nuclear division;regulation of protein catabolic process;regulation of protein heterodimerization activity;regulation of protein kinase activity;regulation of protein stability;regulation of small GTPase mediated signal transduction;regulation of stress fiber assembly;sprouting angiogenesis;submandibular salivary gland formation;substantia nigra development;T cell costimulation;vascular endothelial growth factor receptor signaling pathway;viral RNA genome replication;Wnt signaling pathway, planar cell polarity pathway","apolipoprotein A-I receptor binding;GBD domain binding;GTP binding;GTPase activity;GTP-dependent protein binding;identical protein binding;mitogen-activated protein kinase kinase kinase binding;protein kinase binding;protein serine/threonine kinase activity;Rho GDP-dissociation inhibitor binding;thioesterase binding;ubiquitin protein ligase activity","apical part of cell;cell-cell junction;cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;dendritic spine;endoplasmic reticulum membrane;extracellular exosome;filopodium;focal adhesion;Golgi membrane;Golgi transport complex;leading edge membrane;membrane;microtubule organizing center;midbody;mitotic spindle;myelin sheath;neuron projection;neuronal cell body;phagocytic vesicle;plasma membrane;protein complex;secretory granule;spindle midzone;storage vacuole","Adherens junction;AGE-RAGE signaling pathway in diabetic complications;Axon guidance;Bacterial invasion of epithelial cells;Chemokine signaling pathway;Endocytosis;Epithelial cell signaling in Helicobacter pylori infection;Fc gamma R-mediated phagocytosis;Focal adhesion;GnRH signaling pathway;Human papillomavirus infection;Leukocyte transendothelial migration;MAPK signaling pathway;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease (NAFLD);Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;Salmonella infection;Shigellosis;T cell receptor signaling pathway;Tight junction;VEGF signaling pathway;Viral carcinogenesis;Yersinia infection",null,null,9,9,8,"42.9","42.9","37.2","21.258",0,"119.16",3025900000,78,"0.149095",1,"-0.182741","-0.429469","sp|P60953|CDC42_HUMAN;tr|Q5JYX0|Q5JYX0_HUMAN;tr|F8WET9|F8WET9_HUMAN;tr|B1AH79|B1AH79_HUMAN;tr|G3V4H1|G3V4H1_HUMAN;tr|G3V476|G3V476_HUMAN;sp|P17081|RHOQ_HUMAN;tr|A0A0C4DH03|A0A0C4DH03_HUMAN;sp|Q9H4E5|RHOJ_HUMAN","sp|P60953|CDC42_HUMAN",1817,"P60953","CDC42_HUMAN","Cell division control protein 42 homolog",null,"CDC42"]
["12.2658","12.3221","12.8234","12.1339",{"$nulls":3},"angiogenesis;branching involved in salivary gland morphogenesis;branching involved in ureteric bud morphogenesis;cell differentiation;cell migration;cell proliferation;cell recognition;cilium assembly;cytoskeleton organization;embryo development;endothelial cell differentiation;extracellular matrix organization;focal adhesion assembly;hair follicle development;integrin-mediated signaling pathway;lung development;morphogenesis of a polarized epithelium;morphogenesis of embryonic epithelium;muscle organ development;neural crest cell migration;odontogenesis of dentin-containing tooth;protein localization to plasma membrane;regulation of cell adhesion;regulation of cell migration;regulation of cell proliferation;regulation of embryonic development;substrate adhesion-dependent cell spreading","integrin binding;structural molecule activity","basal lamina;basement membrane;extracellular exosome;extracellular matrix;extracellular region;extracellular space;laminin-10 complex;laminin-11 complex;laminin-5 complex;nucleus;synaptic cleft","Amoebiasis;ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Pathways in cancer;PI3K-Akt signaling pathway;Small cell lung cancer;Toxoplasmosis",null,null,1,1,1,"0.3","0.3","0.3","399.73","0.001712","3.5169",8908800,6,"0.189257",1,"-0.184702","-0.533981","sp|O15230|LAMA5_HUMAN","sp|O15230|LAMA5_HUMAN",341,"O15230","LAMA5_HUMAN","Laminin subunit alpha-5",null,"LAMA5"]
["20.7234","20.69","20.5232","21.2603",{"$nulls":3},"multicellular organism development;transcription, DNA-templated","GTP binding;identical protein binding;transcription factor binding","cytosol;membrane;nuclear body;polysome",{"$nulls":3},11,11,11,"45.5","45.5","45.5","40.542",0,"36.919",398100000,33,"0.176749",1,"-0.185079","-0.501703","sp|Q9Y295|DRG1_HUMAN;tr|H0YI06|H0YI06_HUMAN","sp|Q9Y295|DRG1_HUMAN",4907,"Q9Y295","DRG1_HUMAN","Developmentally-regulated GTP-binding protein 1","RG-1","DRG1"]
["20.8709","20.0389","20.7692","20.5134",{"$nulls":3},"mRNA splicing, via spliceosome;RNA processing;RNA splicing;RNA splicing, via transesterification reactions","RNA binding","catalytic step 2 spliceosome;cytosol;nuclear speck;nucleoplasm;precatalytic spliceosome;small nucleolar ribonucleoprotein complex;U5 snRNP","Spliceosome",null,null,16,16,16,"62.2","62.2","62.2","39.31",0,"323.31",1383100000,80,"0.148651",1,"-0.186409","-0.428299","sp|Q96DI7|SNR40_HUMAN;tr|Q9NSS8|Q9NSS8_HUMAN","sp|Q96DI7|SNR40_HUMAN",3654,"Q96DI7","SNR40_HUMAN","U5 small nuclear ribonucleoprotein 40 kDa protein","5 snRNP 40 kDa protein;5-40K","SNRNP40"]
["15.7833",1,"16.1576",1,{"$nulls":3},"neurotransmitter secretion",null,"presynaptic active zone",{"$nulls":3},3,2,2,"7.8","5.7","5.7","74.205","0.00069077","4.639",45630000,4,"0.00546221",1,"-0.187137","-0.0176768","tr|R4GN36|R4GN36_HUMAN;sp|O75145|LIPA3_HUMAN;tr|R4GNF1|R4GNF1_HUMAN","tr|R4GN36|R4GN36_HUMAN;sp|O75145|LIPA3_HUMAN;tr|R4GNF1|R4GNF1_HUMAN",526,"R4GN36","R4GN36_HUMAN",null,null,"PPFIA3"]
["20.1048","20.2013","21.0604","19.6215",{"$nulls":3},"cholesterol biosynthetic process;fatty acid metabolic process;steroid metabolic process;sterol biosynthetic process","C-4 methylsterol oxidase activity;iron ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;plasma membrane","Metabolic pathways;Steroid biosynthesis",null,null,2,2,2,"8.9","8.9","8.9","35.215",0,"37.402",163130000,14,"0.0868192",1,"-0.187879","-0.260561","sp|Q15800|MSMO1_HUMAN;tr|D6REA2|D6REA2_HUMAN;tr|D6RDP9|D6RDP9_HUMAN;tr|D6R952|D6R952_HUMAN","sp|Q15800|MSMO1_HUMAN;tr|D6REA2|D6REA2_HUMAN;tr|D6RDP9|D6RDP9_HUMAN;tr|D6R952|D6R952_HUMAN",2523,"Q15800","MSMO1_HUMAN","Methylsterol monooxygenase 1",null,"MSMO1"]
["20.3861","21.4753","21.0348","21.2031",{"$nulls":3},"folic acid metabolic process;one-carbon metabolic process;tetrahydrofolate metabolic process","magnesium ion binding;methenyltetrahydrofolate cyclohydrolase activity;methylenetetrahydrofolate dehydrogenase (NAD+) activity;methylenetetrahydrofolate dehydrogenase (NADP+) activity;phosphate ion binding","extracellular space;mitochondrial matrix;mitochondrion","Metabolic pathways;One carbon pool by folate",null,null,11,11,11,"44.9","44.9","44.9","37.895",0,"189.04",623620000,40,"0.116268",1,"-0.188312","-0.341725","sp|P13995|MTDC_HUMAN;tr|B9A062|B9A062_HUMAN;tr|B8ZZU9|B8ZZU9_HUMAN","sp|P13995|MTDC_HUMAN;tr|B9A062|B9A062_HUMAN",1038,"P13995","MTDC_HUMAN","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial",null,"MTHFD2"]
["24.1987","24.2423","24.4499","24.3703",{"$nulls":4},"oxidoreductase activity",null,"Arachidonic acid metabolism;Folate biosynthesis;Metabolic pathways;Ovarian steroidogenesis;Steroid hormone biosynthesis",null,null,16,16,8,"58.5","58.5","40.9","36.867",0,"284.26",3218400000,121,"1.27675",1,"-0.189549","-4.17446","tr|A0A0A0MSS8|A0A0A0MSS8_HUMAN;sp|P42330|AK1C3_HUMAN;tr|S4R3Z2|S4R3Z2_HUMAN;tr|S4R3D5|S4R3D5_HUMAN;sp|P17516|AK1C4_HUMAN","tr|A0A0A0MSS8|A0A0A0MSS8_HUMAN;sp|P42330|AK1C3_HUMAN;tr|S4R3Z2|S4R3Z2_HUMAN",1469,"A0A0A0MSS8","A0A0A0MSS8_HUMAN",null,null,"AKR1C3"]
["26.2661","26.1822","26.6398","26.1894",{"$nulls":3},"epidermis development;lipid metabolic process;neutrophil degranulation;triglyceride catabolic process","fatty acid binding;lipid binding","azurophil granule lumen;cytoplasm;cytosol;extracellular exosome;extracellular region;nucleoplasm;plasma membrane;secretory granule membrane","PPAR signaling pathway",null,null,8,8,8,"50.4","50.4","50.4","15.164",0,"126.88",4845200000,116,"0.307004",1,"-0.190428","-0.831473","sp|Q01469|FABP5_HUMAN;tr|I6L8B7|I6L8B7_HUMAN;sp|A8MUU1|FB5L3_HUMAN","sp|Q01469|FABP5_HUMAN;tr|I6L8B7|I6L8B7_HUMAN",2046,"Q01469","FABP5_HUMAN","Fatty acid-binding protein, epidermal",null,"FABP5"]
["25.8566","26.0418","26.2222","26.0591",{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of transcription from RNA polymerase II promoter;RNA metabolic process;viral RNA genome replication","cadherin binding;mRNA binding;RNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific single stranded DNA binding;single-stranded DNA binding","cytoplasm;cytoplasmic ribonucleoprotein granule;cytosol;extracellular exosome;membrane;nuclear speck;nucleoplasm","Ferroptosis;Spliceosome",null,null,17,17,12,"72.8","72.8",61,"37.497",0,"323.31",10475000000,314,"0.583382",1,"-0.191418","-1.55134","sp|Q15365|PCBP1_HUMAN","sp|Q15365|PCBP1_HUMAN",2475,"Q15365","PCBP1_HUMAN","Poly(rC)-binding protein 1",null,"PCBP1"]
["20.9368","19.9745","21.1035","20.1918",{"$nulls":5},"cytoskeleton",{"$nulls":3},18,18,18,"41.5","41.5","41.5","70.055",0,"87.187",1203600000,114,"0.0972972",1,"-0.192035","-0.289747","tr|E7EV99|E7EV99_HUMAN;tr|E7ENY0|E7ENY0_HUMAN;sp|P35611|ADDA_HUMAN;tr|H0Y9H2|H0Y9H2_HUMAN;tr|A0A0A0MSR2|A0A0A0MSR2_HUMAN;tr|D6RF25|D6RF25_HUMAN;tr|D6RJE2|D6RJE2_HUMAN;tr|H0YFD8|H0YFD8_HUMAN;tr|H0YG19|H0YG19_HUMAN;tr|D6RAH3|D6RAH3_HUMAN;sp|P35612|ADDB_HUMAN","tr|E7EV99|E7EV99_HUMAN;tr|E7ENY0|E7ENY0_HUMAN;sp|P35611|ADDA_HUMAN;tr|H0Y9H2|H0Y9H2_HUMAN;tr|A0A0A0MSR2|A0A0A0MSR2_HUMAN",1392,"E7EV99","E7EV99_HUMAN",null,null,"ADD1"]
["20.6192","20.6666","20.6055","21.0658",{"$nulls":3},"negative regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;identical protein binding;protein heterodimerization activity;transcription corepressor activity","nucleus",{"$nulls":3},4,4,4,"26.3","26.3","26.3","22.35",0,"10.818",141320000,21,"0.30768",1,"-0.192769","-0.833166","sp|Q14919|NC2A_HUMAN;tr|C9JCC6|C9JCC6_HUMAN;tr|E9PNC7|E9PNC7_HUMAN;tr|E9PQX9|E9PQX9_HUMAN;tr|E9PMW2|E9PMW2_HUMAN","sp|Q14919|NC2A_HUMAN;tr|C9JCC6|C9JCC6_HUMAN;tr|E9PNC7|E9PNC7_HUMAN;tr|E9PQX9|E9PQX9_HUMAN",2403,"Q14919","NC2A_HUMAN","Dr1-associated corepressor",null,"DRAP1"]
["19.7713","19.6436","20.4598","19.3417",{"$nulls":3},"regulation of hair cycle",null,"cytoplasm",{"$nulls":3},13,13,13,"29.8","29.8","29.8","66.86",0,"31.928",381210000,33,"0.116923",1,"-0.193298","-0.343499","sp|Q8TE67|ES8L3_HUMAN;tr|A0A087X104|A0A087X104_HUMAN","sp|Q8TE67|ES8L3_HUMAN",3389,"Q8TE67","ES8L3_HUMAN","Epidermal growth factor receptor kinase substrate 8-like protein 3","PS8-like protein 3","EPS8L3"]
["18.0431","18.5271","18.1934","18.7643",{"$nulls":3},"beta-catenin-TCF complex assembly;endodermal cell fate commitment;histone H2B ubiquitination;histone monoubiquitination;mRNA polyadenylation;negative regulation of myeloid cell differentiation;positive regulation of mRNA 3'-end processing;positive regulation of transcription elongation from RNA polymerase II promoter;positive regulation of transcription from RNA polymerase II promoter;protein ubiquitination;stem cell population maintenance;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;Wnt signaling pathway","RNA polymerase II C-terminal domain phosphoserine binding","Cdc73/Paf1 complex;centrosome;fibrillar center;nucleoplasm",{"$nulls":3},10,10,10,24,24,24,"75.403",0,"24.307",228520000,45,"0.183018",1,"-0.193808","-0.517907","sp|Q8WVC0|LEO1_HUMAN","sp|Q8WVC0|LEO1_HUMAN",3436,"Q8WVC0","LEO1_HUMAN","RNA polymerase-associated protein LEO1",null,"LEO1"]
["16.3296","16.4553","17.4611","15.7123",{"$nulls":3},"developmental process;glycerophospholipid catabolic process;phosphatidylcholine metabolic process","lysophospholipase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane","Glycerophospholipid metabolism",null,null,32,32,32,"29.2","29.2","29.2","149.99",0,"186.75",1812500000,262,"0.0730167",1,"-0.194202","-0.221523","sp|Q8IY17|PLPL6_HUMAN;tr|M0R2H4|M0R2H4_HUMAN;tr|M0R2K2|M0R2K2_HUMAN;tr|M0R2C2|M0R2C2_HUMAN;tr|M0QYF5|M0QYF5_HUMAN;tr|M0QZK5|M0QZK5_HUMAN;tr|M0QYT1|M0QYT1_HUMAN;tr|M0QXH7|M0QXH7_HUMAN","sp|Q8IY17|PLPL6_HUMAN",3154,"Q8IY17","PLPL6_HUMAN","Neuropathy target esterase",null,"PNPLA6"]
["18.8856","19.309","19.0668","19.5168",{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","metal ion binding;transferase activity","nucleoplasm",{"$nulls":3},9,9,9,"27.1","27.1","27.1","61.687",0,"23.108",273650000,17,"0.226681",1,"-0.194482","-0.629467","sp|Q8IU81|I2BP1_HUMAN","sp|Q8IU81|I2BP1_HUMAN",3098,"Q8IU81","I2BP1_HUMAN","Interferon regulatory factor 2-binding protein 1","RF-2-binding protein 1;RF-2BP1","IRF2BP1"]
["19.66","19.3154","19.797","19.5696",{"$nulls":3},"adherens junction assembly;adherens junction organization;bundle of His cell-Purkinje myocyte adhesion involved in cell communication;cell migration;cell-cell adhesion;cellular response to indole-3-methanol;cornification;cytoskeletal anchoring at plasma membrane;desmosome assembly;detection of mechanical stimulus;endothelial cell-cell adhesion;keratinization;neutrophil degranulation;positive regulation of canonical Wnt signaling pathway;positive regulation of DNA binding transcription factor activity;positive regulation of protein import into nucleus;protein heterooligomerization;protein localization to plasma membrane;regulation of cell proliferation;regulation of heart rate by cardiac conduction;regulation of ventricular cardiac muscle cell action potential","alpha-catenin binding;cadherin binding;cell adhesion molecule binding;cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;protein homodimerization activity;protein kinase binding;protein phosphatase binding;signal transducer activity;structural constituent of cell wall;structural molecule activity;transcription coactivator activity","actin cytoskeleton;apicolateral plasma membrane;catenin complex;cell-cell adherens junction;cell-cell junction;cornified envelope;cytoplasm;cytoplasmic side of plasma membrane;cytoskeleton;cytosol;desmosome;extracellular exosome;extracellular matrix;extracellular region;fascia adherens;ficolin-1-rich granule lumen;focal adhesion;gamma-catenin-TCF7L2 complex;intercalated disc;intermediate filament;lateral plasma membrane;nucleus;plasma membrane;protein-DNA complex;specific granule lumen;Z disc;zonula adherens","Acute myeloid leukemia;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Gastric cancer;Pathways in cancer;Transcriptional misregulation in cancer",null,null,18,14,14,"33.4","27.4","27.4","81.744",0,"53.472",426310000,56,"0.353192",1,"-0.195589","-0.947453","sp|P14923|PLAK_HUMAN;tr|C9JTX4|C9JTX4_HUMAN;tr|C9J826|C9J826_HUMAN;tr|C9JK18|C9JK18_HUMAN;tr|C9JKY1|C9JKY1_HUMAN","sp|P14923|PLAK_HUMAN",1054,"P14923","PLAK_HUMAN","Junction plakoglobin",null,"JUP"]
["19.7926","19.3405","19.8319","19.6934",{"$nulls":9},1,1,1,"6.6","6.6","6.6","20.791","0.0019177","3.4701",54507000,6,"0.306224",1,"-0.196116","-0.829518","tr|A0A087WY88|A0A087WY88_HUMAN;sp|Q8N5M9|JAGN1_HUMAN","tr|A0A087WY88|A0A087WY88_HUMAN;sp|Q8N5M9|JAGN1_HUMAN",3246,"A0A087WY88"]
["16.1838",1,"16.5773",1,{"$nulls":3},"cellular protein metabolic process;post-translational protein modification",null,"endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of membrane",{"$nulls":3},3,3,3,"4.7","4.7","4.7","110.11","0.00025145","6.4858",29637000,4,"0.00559131",1,"-0.196779","-0.018092","sp|Q24JP5|T132A_HUMAN;tr|H0YFQ2|H0YFQ2_HUMAN","sp|Q24JP5|T132A_HUMAN",2587,"Q24JP5","T132A_HUMAN","Transmembrane protein 132A",null,"TMEM132A"]
["23.441","23.2996","23.5767","23.5616",{"$nulls":3},"erythrocyte differentiation;iron ion homeostasis;iron ion transport","ion transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},12,12,12,"50.6","50.6","50.6","35.619",0,"143.55",2299800000,180,"0.968256",1,"-0.198834","-2.79706","sp|Q9H9B4|SFXN1_HUMAN;tr|D6RFI0|D6RFI0_HUMAN;tr|S4R2X2|S4R2X2_HUMAN;tr|D6RDG7|D6RDG7_HUMAN;tr|D6RAE9|D6RAE9_HUMAN","sp|Q9H9B4|SFXN1_HUMAN;tr|D6RFI0|D6RFI0_HUMAN;tr|S4R2X2|S4R2X2_HUMAN",4274,"Q9H9B4","SFXN1_HUMAN","Sideroflexin-1",null,"SFXN1"]
["19.4885",1,"19.8863",1,{"$nulls":3},"cellular response to glucose stimulus;cerebral cortex regionalization;embryonic brain development;mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;positive regulation of mRNA splicing, via spliceosome;protein oligomerization;regulation of alternative mRNA splicing, via spliceosome;regulation of RNA splicing;response to reactive oxygen species;RNA splicing, via transesterification reactions","identical protein binding;mRNA binding;poly-purine tract binding;pre-mRNA binding;protein domain specific binding;RNA binding","nuclear inner membrane;nucleoplasm;nucleus;perinuclear region of cytoplasm;spliceosomal complex","Spliceosome",null,null,3,3,3,"13.9","13.9","13.9","33.665",0,"7.9932",57034000,9,"0.00464739",1,"-0.198931","-0.0150537","sp|P62995|TRA2B_HUMAN;tr|H7BXF3|H7BXF3_HUMAN;tr|H7C2L4|H7C2L4_HUMAN","sp|P62995|TRA2B_HUMAN;tr|H7BXF3|H7BXF3_HUMAN",1934,"P62995","TRA2B_HUMAN","Transformer-2 protein homolog beta","RA-2 beta;RA2-beta;TRA2-beta","TRA2B"]
["20.3183","20.103","20.5594","20.2605",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,27,27,27,"7.2634","0.00025504","6.8041",37155000,8,"0.406418",1,"-0.19929","-1.08226","tr|Q9HB66|Q9HB66_HUMAN","tr|Q9HB66|Q9HB66_HUMAN",5301,"Q9HB66","Q9HB66_HUMAN"]
["19.5689","19.1969","19.5229","19.6431",{"$nulls":3},"cell cycle;chromatin assembly;DNA repair;DNA replication;DNA replication-dependent nucleosome assembly;protein complex assembly;regulation of transcription, DNA-templated;transcription, DNA-templated","chromatin binding;histone binding;unfolded protein binding","CAF-1 complex;cytoplasm;nuclear chromatin;nucleoplasm;nucleus;protein complex",{"$nulls":3},15,15,15,"40.8","40.8","40.8","61.492",0,"103.62",1779600000,123,"0.383363",1,"-0.200103","-1.02365","sp|Q13112|CAF1B_HUMAN","sp|Q13112|CAF1B_HUMAN",2204,"Q13112","CAF1B_HUMAN","Chromatin assembly factor 1 subunit B","AF-1 subunit B","CHAF1B"]
["18.4304","19.1538","18.5046","19.4814",{"$nulls":3},"apoptotic process;protein localization","actin binding","cytoskeleton;cytosol;focal adhesion",{"$nulls":3},12,12,12,"23.8","23.8","23.8","76.763",0,"32.69",291320000,45,"0.112181",1,"-0.200928","-0.330613","sp|Q8IZW8|TENS4_HUMAN","sp|Q8IZW8|TENS4_HUMAN",3183,"Q8IZW8","TENS4_HUMAN","Tensin-4",null,"TNS4"]
["20.8858","21.49","21.5921","21.1885",{"$nulls":3},"intracellular signal transduction","ATP binding;magnesium ion binding;protein serine/threonine kinase activity","cytosol;nucleus",{"$nulls":3},26,26,18,"44.3","44.3",33,"81.471",0,"83.512",1032600000,97,"0.1982",1,"-0.202337","-0.556934","tr|E9PGT3|E9PGT3_HUMAN;sp|Q15418|KS6A1_HUMAN;tr|B7Z3B5|B7Z3B5_HUMAN;tr|E9PMM7|E9PMM7_HUMAN;tr|Q5SVM7|Q5SVM7_HUMAN;tr|E9PAN7|E9PAN7_HUMAN;tr|Q5SVM6|Q5SVM6_HUMAN;tr|E9PPN6|E9PPN6_HUMAN","tr|E9PGT3|E9PGT3_HUMAN;sp|Q15418|KS6A1_HUMAN",2488,"E9PGT3","E9PGT3_HUMAN","Ribosomal protein S6 kinase {ECO:0000256|PIRNR:PIRNR000606}",null,"RPS6KA1"]
["21.0011","20.2718","21.1566","20.523",{"$nulls":9},2,2,2,"28.1","28.1","28.1","9.632",0,"8.3002",97206000,10,"0.145828",1,"-0.203289","-0.420844","tr|E5RFZ8|E5RFZ8_HUMAN;tr|E5RGA7|E5RGA7_HUMAN;tr|E5RJ40|E5RJ40_HUMAN;tr|E5RJG5|E5RJG5_HUMAN;tr|E5RIP4|E5RIP4_HUMAN;sp|Q15043|S39AE_HUMAN","tr|E5RFZ8|E5RFZ8_HUMAN;tr|E5RGA7|E5RGA7_HUMAN;tr|E5RJ40|E5RJ40_HUMAN;tr|E5RJG5|E5RJG5_HUMAN;tr|E5RIP4|E5RIP4_HUMAN;sp|Q15043|S39AE_HUMAN",2435,"E5RFZ8","E5RFZ8_HUMAN",null,null,"SLC39A14"]
["20.4057","21.2292","21.2675","20.7748",{"$nulls":4},"DNA binding","integral component of membrane;nucleus",{"$nulls":3},2,2,2,"19.5","19.5","19.5","15.32",0,"9.3807",368790000,52,"0.147203",1,"-0.203666","-0.424477","tr|Q5SZE2|Q5SZE2_HUMAN;tr|Q5SZE3|Q5SZE3_HUMAN;tr|H0YKH6|H0YKH6_HUMAN;tr|Q5SZE4|Q5SZE4_HUMAN;tr|Q5SZE1|Q5SZE1_HUMAN;sp|Q96G23|CERS2_HUMAN;tr|H0YNU7|H0YNU7_HUMAN","tr|Q5SZE2|Q5SZE2_HUMAN;tr|Q5SZE3|Q5SZE3_HUMAN;tr|H0YKH6|H0YKH6_HUMAN;tr|Q5SZE4|Q5SZE4_HUMAN;tr|Q5SZE1|Q5SZE1_HUMAN;sp|Q96G23|CERS2_HUMAN;tr|H0YNU7|H0YNU7_HUMAN",3692,"Q5SZE2","Q5SZE2_HUMAN",null,null,"CERS2"]
["21.4147","21.2588","21.5425","21.5399",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;protein targeting;regulation of defense response to virus by virus;vesicle targeting",null,"clathrin adaptor complex;clathrin-coated endocytic vesicle membrane;cytoplasmic vesicle membrane;cytosol;Golgi membrane;intracellular membrane-bounded organelle;lysosomal membrane;trans-Golgi network membrane","Human immunodeficiency virus 1 infection;Lysosome",null,null,10,10,7,"28.1","28.1","21.3","48.108",0,"62.398",658010000,50,"0.921542",1,"-0.204446","-2.6228","sp|Q9Y6Q5|AP1M2_HUMAN;tr|K7EJJ1|K7EJJ1_HUMAN;tr|K7ERH5|K7ERH5_HUMAN;tr|K7EL08|K7EL08_HUMAN;tr|K7EPR4|K7EPR4_HUMAN;tr|K7EK69|K7EK69_HUMAN;tr|K7EMG5|K7EMG5_HUMAN;tr|K7EQX3|K7EQX3_HUMAN","sp|Q9Y6Q5|AP1M2_HUMAN;tr|K7EJJ1|K7EJJ1_HUMAN",5112,"Q9Y6Q5","AP1M2_HUMAN","AP-1 complex subunit mu-2",null,"AP1M2"]
["20.9825","21.4041","21.1697","21.6277",{"$nulls":3},"peptide metabolic process;protein polyubiquitination","metal ion binding;metalloendopeptidase activity;peptide binding","cytosol;mitochondrial intermembrane space","African trypanosomiasis;Renin-angiotensin system",null,null,14,14,14,"28.6","28.6","28.6","78.839",0,"85.065",786680000,58,"0.238718",1,"-0.205378","-0.659917","sp|P52888|THOP1_HUMAN;tr|K7EP46|K7EP46_HUMAN;tr|K7EKB6|K7EKB6_HUMAN;tr|K7EL02|K7EL02_HUMAN;tr|K7EIK4|K7EIK4_HUMAN;tr|K7EMU4|K7EMU4_HUMAN;tr|K7EL32|K7EL32_HUMAN","sp|P52888|THOP1_HUMAN;tr|K7EP46|K7EP46_HUMAN",1698,"P52888","THOP1_HUMAN","Thimet oligopeptidase",null,"THOP1"]
["25.5401","25.2208","25.6973","25.4746",{"$nulls":3},"ATP metabolic process;cardiac muscle contraction;cell adhesion;cell communication by electrical coupling involved in cardiac conduction;cellular calcium ion homeostasis;cellular potassium ion homeostasis;cellular sodium ion homeostasis;ion transmembrane transport;leukocyte migration;membrane repolarization;membrane repolarization during cardiac muscle cell action potential;positive regulation of ATPase activity;positive regulation of calcium:sodium antiporter activity;positive regulation of potassium ion import;positive regulation of potassium ion transmembrane transporter activity;positive regulation of sodium ion export across plasma membrane;potassium ion import;potassium ion import across plasma membrane;protein localization to plasma membrane;protein stabilization;protein transport into plasma membrane raft;regulation of cardiac conduction;regulation of cardiac muscle contraction by calcium ion signaling;regulation of gene expression;relaxation of cardiac muscle;response to hypoxia;sodium ion export across plasma membrane","ATPase activator activity;ATPase binding;MHC class II protein complex binding;protein C-terminus binding;protein kinase binding;sodium:potassium-exchanging ATPase activity","apical plasma membrane;basolateral plasma membrane;caveola;extracellular exosome;extracellular vesicle;intercalated disc;intracellular;membrane;myelin sheath;plasma membrane;sarcolemma;sodium:potassium-exchanging ATPase complex","Adrenergic signaling in cardiomyocytes;Aldosterone synthesis and secretion;Aldosterone-regulated sodium reabsorption;Bile secretion;cAMP signaling pathway;Carbohydrate digestion and absorption;Cardiac muscle contraction;cGMP-PKG signaling pathway;Endocrine and other factor-regulated calcium reabsorption;Gastric acid secretion;Insulin secretion;Mineral absorption;Pancreatic secretion;Protein digestion and absorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Thyroid hormone signaling pathway;Thyroid hormone synthesis",null,null,9,9,9,"37.3","37.3","37.3","35.061",0,"232.04",8700800000,229,"0.396125",1,"-0.205557","-1.05604","sp|P05026|AT1B1_HUMAN;tr|V9GYR2|V9GYR2_HUMAN","sp|P05026|AT1B1_HUMAN;tr|V9GYR2|V9GYR2_HUMAN",853,"P05026","AT1B1_HUMAN","Sodium/potassium-transporting ATPase subunit beta-1",null,"ATP1B1"]
["24.5619","24.7991","24.9532","24.8227",{"$nulls":3},"10-formyltetrahydrofolate biosynthetic process;embryonic neurocranium morphogenesis;embryonic viscerocranium morphogenesis;folic acid metabolic process;heart development;histidine biosynthetic process;methionine biosynthetic process;methionine metabolic process;neural tube closure;neutrophil homeostasis;one-carbon metabolic process;purine nucleobase biosynthetic process;purine nucleotide biosynthetic process;serine family amino acid biosynthetic process;serine family amino acid metabolic process;somite development;tetrahydrofolate interconversion;transsulfuration","ATP binding;formate-tetrahydrofolate ligase activity;methenyltetrahydrofolate cyclohydrolase activity;methylenetetrahydrofolate dehydrogenase (NAD+) activity;methylenetetrahydrofolate dehydrogenase (NADP+) activity;methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity","cytoplasm;cytosol;extracellular exosome;membrane;mitochondrion","Metabolic pathways;One carbon pool by folate",null,null,51,51,50,"69.5","69.5","68.4","101.56",0,"323.31",13272000000,445,"0.576531",1,"-0.207421","-1.53234","sp|P11586|C1TC_HUMAN;tr|F5H2F4|F5H2F4_HUMAN;tr|V9GYY3|V9GYY3_HUMAN;tr|V9GY75|V9GY75_HUMAN","sp|P11586|C1TC_HUMAN;tr|F5H2F4|F5H2F4_HUMAN",1000,"P11586","C1TC_HUMAN","C-1-tetrahydrofolate synthase, cytoplasmic","1-THF synthase","MTHFD1"]
["22.9664","22.6227","23.072","22.9336",{"$nulls":3},"nitric oxide biosynthetic process;oxidation-reduction process;regulation of nitric-oxide synthase activity;tetrahydrobiopterin biosynthetic process","aldo-keto reductase (NADP) activity;NADP binding;sepiapterin reductase activity","cytosol;extracellular exosome;nucleoplasm","Folate biosynthesis;Metabolic pathways",null,null,10,10,10,46,46,46,"28.048",0,"122.73",918280000,65,"0.422673",1,"-0.208241","-1.12382","sp|P35270|SPRE_HUMAN;REV__sp|Q16649|NFIL3_HUMAN","sp|P35270|SPRE_HUMAN",1383,"P35270","SPRE_HUMAN","Sepiapterin reductase","PR","SPR"]
["24.1815","23.1016","24.3553","23.35",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;mRNA processing;mRNA splicing, via spliceosome;positive regulation of protein targeting to mitochondrion;regulation of autophagy of mitochondrion;RNA export from nucleus;RNA splicing;termination of RNA polymerase II transcription","metal ion binding;pre-mRNA 3'-splice site binding;RNA binding","Cajal body;catalytic step 2 spliceosome;nuclear speck;nucleoplasm;spliceosomal complex;U2AF","Shigellosis;Spliceosome",null,null,7,7,7,"38.3","38.3","38.3","27.872",0,"115.2",2124200000,56,"0.0959986",1,"-0.211096","-0.28615","sp|Q01081|U2AF1_HUMAN;sp|Q8WU68|U2AF4_HUMAN;tr|M0QYK5|M0QYK5_HUMAN;tr|M0R2N4|M0R2N4_HUMAN;tr|K7EJH3|K7EJH3_HUMAN;tr|K7EJM7|K7EJM7_HUMAN","sp|Q01081|U2AF1_HUMAN",2039,"Q01081","U2AF1_HUMAN","Splicing factor U2AF 35 kDa subunit",null,"U2AF1"]
["13.0754",1,"13.5",1,{"$nulls":3},"regulation of transcription, DNA-templated;transcription, DNA-templated","DNA binding;metal ion binding","nucleus",{"$nulls":3},1,1,1,3,3,3,"50.602","0.002333","3.4049",12240000,6,"0.00756635",1,"-0.212287","-0.0244289","sp|Q96C00|ZBTB9_HUMAN","sp|Q96C00|ZBTB9_HUMAN",3623,"Q96C00","ZBTB9_HUMAN","Zinc finger and BTB domain-containing protein 9",null,"ZBTB9"]
["23.0868","23.064","23.3199","23.2594",{"$nulls":3},"carbohydrate biosynthetic process;CMP-N-acetylneuraminate biosynthetic process","N-acetylneuraminate synthase activity;N-acylneuraminate cytidylyltransferase activity;N-acylneuraminate-9-phosphate synthase activity","cytoplasm;cytosol;extracellular exosome","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,11,11,11,"40.7","40.7","40.7","40.307",0,"158.21",1220100000,82,"1.65761",1,"-0.214241","-6.63049","sp|Q9NR45|SIAS_HUMAN;tr|Q5TBR0|Q5TBR0_HUMAN;tr|Q5TBR1|Q5TBR1_HUMAN","sp|Q9NR45|SIAS_HUMAN",4408,"Q9NR45","SIAS_HUMAN","Sialic acid synthase",null,"NANS"]
["18.5067","18.9108","18.969","18.878",{"$nulls":3},"anatomical structure morphogenesis;cell differentiation;double-strand break repair;histone dephosphorylation;multicellular organism development;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;positive regulation of DNA repair;regulation of transcription, DNA-templated;response to ionizing radiation;transcription, DNA-templated;visual perception","metal ion binding;protein tyrosine phosphatase activity","centrosome;cytoplasm;nucleoplasm;nucleus;transcription factor complex",{"$nulls":3},5,5,5,"14.5","14.5","14.5","62.662",0,"13.01",136110000,13,"0.388541",1,"-0.214732","-1.03678","sp|Q99504|EYA3_HUMAN;tr|B1APR7|B1APR7_HUMAN","sp|Q99504|EYA3_HUMAN;tr|B1APR7|B1APR7_HUMAN",3850,"Q99504","EYA3_HUMAN","Eyes absent homolog 3",null,"EYA3"]
["18.5742","18.7468","19.3708","18.3812",{"$nulls":4},"calcium ion binding",{"$nulls":4},2,2,2,"22.1","22.1","22.1","12.127","0.00068934","4.5972",43670000,5,"0.148924",1,"-0.215493","-0.429017","tr|E9PE24|E9PE24_HUMAN;tr|E7ER47|E7ER47_HUMAN;sp|P62760|VISL1_HUMAN","tr|E9PE24|E9PE24_HUMAN;tr|E7ER47|E7ER47_HUMAN;sp|P62760|VISL1_HUMAN",1906,"E9PE24","E9PE24_HUMAN",null,null,"VSNL1"]
["21.6062","20.9498","21.8819","21.1051",{"$nulls":3},"apoptotic process;blood circulation;cellular response to insulin stimulus;cellular response to interferon-beta;cellular response to interferon-gamma;cellular response to organic cyclic compound;defense response to virus;interferon-gamma-mediated signaling pathway;interleukin-12-mediated signaling pathway;JAK-STAT cascade;macrophage derived foam cell differentiation;metanephric mesenchymal cell differentiation;metanephric mesenchymal cell proliferation involved in metanephros development;negative regulation by virus of viral protein levels in host cell;negative regulation of angiogenesis;negative regulation of endothelial cell proliferation;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;negative regulation of metanephric nephron tubule epithelial cell differentiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of defense response to virus by host;positive regulation of erythrocyte differentiation;positive regulation of interferon-alpha production;positive regulation of mesenchymal cell proliferation;positive regulation of nitric-oxide synthase biosynthetic process;positive regulation of smooth muscle cell proliferation;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;regulation of apoptotic process;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway;renal tubule development;response to cAMP;response to cytokine;response to drug;response to hydrogen peroxide;response to interferon-beta;response to mechanical stimulus;response to nutrient;response to peptide hormone;transcription, DNA-templated;tumor necrosis factor-mediated signaling pathway;type I interferon signaling pathway;viral process","cadherin binding;CCR5 chemokine receptor binding;core promoter binding;DNA binding transcription factor activity;double-stranded DNA binding;enzyme binding;histone acetyltransferase binding;histone binding;identical protein binding;nuclear hormone receptor binding;promoter-specific chromatin binding;protein homodimerization activity;protein phosphatase 2A binding;repressing transcription factor binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;signal transducer activity;transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;tumor necrosis factor receptor binding;ubiquitin-like protein ligase binding","axon;cytoplasm;cytosol;dendrite;nuclear chromatin;nucleolus;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex","AGE-RAGE signaling pathway in diabetic complications;Chemokine signaling pathway;C-type lectin receptor signaling pathway;Epstein-Barr virus infection;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human papillomavirus infection;Inflammatory bowel disease (IBD);Influenza A;Jak-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Measles;Necroptosis;NOD-like receptor signaling pathway;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Prolactin signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis",null,null,21,21,21,"36.3","36.3","36.3","87.334",0,"121.54",1018800000,71,"0.146978",1,"-0.215529","-0.423883","sp|P42224|STAT1_HUMAN;tr|J3KPM9|J3KPM9_HUMAN;tr|E7EPD2|E7EPD2_HUMAN;tr|D2KFR9|D2KFR9_HUMAN;tr|E7ENM1|E7ENM1_HUMAN;tr|E9PH66|E9PH66_HUMAN;tr|H7BZB5|H7BZB5_HUMAN;tr|H7BZ88|H7BZ88_HUMAN","sp|P42224|STAT1_HUMAN;tr|J3KPM9|J3KPM9_HUMAN",1466,"P42224","STAT1_HUMAN","Signal transducer and activator of transcription 1-alpha/beta",null,"STAT1"]
["19.2465","19.8479","19.7236","19.8059",{"$nulls":9},2,2,2,"27.7","27.7","27.7","6.7436","0.0015018","3.5549",50786000,5,"0.261273",1,"-0.217544","-0.716741","tr|K7ELD9|K7ELD9_HUMAN;tr|K7ENG9|K7ENG9_HUMAN;tr|K7ELS8|K7ELS8_HUMAN;sp|O43760|SNG2_HUMAN","tr|K7ELD9|K7ELD9_HUMAN;tr|K7ENG9|K7ENG9_HUMAN;tr|K7ELS8|K7ELS8_HUMAN;sp|O43760|SNG2_HUMAN",430,"K7ELD9","K7ELD9_HUMAN",null,null,"SYNGR2"]
["27.2194","26.798","27.3163","27.1361",{"$nulls":3},"canonical glycolysis;gluconeogenesis;glycolytic process;neutrophil degranulation;regulation of glycolytic process;regulation of pentose-phosphate shunt;respiratory burst","2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;bisphosphoglycerate mutase activity;hydrolase activity;phosphoglycerate mutase activity;protein kinase binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;membrane;secretory granule lumen","Biosynthesis of amino acids;Carbon metabolism;Central carbon metabolism in cancer;Glucagon signaling pathway;Glycine, serine and threonine metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways",null,null,16,16,16,"73.6","73.6","73.6","28.804",0,"323.31",16200000000,415,"0.353956",1,"-0.217546","-0.949376","sp|P18669|PGAM1_HUMAN;sp|P15259|PGAM2_HUMAN;sp|Q8N0Y7|PGAM4_HUMAN","sp|P18669|PGAM1_HUMAN",1121,"P18669","PGAM1_HUMAN","Phosphoglycerate mutase 1",null,"PGAM1"]
["19.6442","18.8043","18.5083","20.3788",{"$nulls":3},"cholesterol biosynthetic process;isopentenyl diphosphate biosynthetic process, mevalonate pathway","ATP binding;mevalonate kinase activity","cytoplasm",{"$nulls":3},5,5,5,"20.6","20.6","20.6","37.171",0,"14.569",111320000,11,"0.0703361",1,"-0.219249","-0.213858","tr|F5H8H2|F5H8H2_HUMAN;sp|Q03426|KIME_HUMAN;tr|A0A0B4J236|A0A0B4J236_HUMAN;tr|F5H092|F5H092_HUMAN;tr|F5GXC0|F5GXC0_HUMAN","tr|F5H8H2|F5H8H2_HUMAN;sp|Q03426|KIME_HUMAN",2084,"F5H8H2","F5H8H2_HUMAN","Mevalonate kinase {ECO:0000256|RuleBase:RU363087}","K {ECO:0000256|RuleBase:RU363087}"]
["21.4597","21.243","21.6262","21.5165",{"$nulls":3},"cellular amino acid biosynthetic process;chemical synaptic transmission;glutamate biosynthetic process;glutamate secretion;glutamine catabolic process;protein homotetramerization;regulation of respiratory gaseous exchange by neurological system process;suckling behavior","glutaminase activity","cytosol;mitochondrial matrix;mitochondrion","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Central carbon metabolism in cancer;D-Glutamine and D-glutamate metabolism;GABAergic synapse;Glutamatergic synapse;Metabolic pathways;MicroRNAs in cancer;Proximal tubule bicarbonate reclamation",null,null,13,13,12,"28.8","28.8","27.7","73.46",0,"165.69",980210000,83,"0.674188",1,"-0.220003","-1.81159","sp|O94925|GLSK_HUMAN;tr|H7BZD1|H7BZD1_HUMAN","sp|O94925|GLSK_HUMAN",675,"O94925","GLSK_HUMAN","Glutaminase kidney isoform, mitochondrial","LS","GLS"]
["20.2397",1,"20.6824",1,{"$nulls":3},"endocytosis",null,"membrane",{"$nulls":3},2,2,2,"32.7","32.7","32.7","12.707","0.00068918","4.5901",22472000,3,"0.00496773",1,"-0.221368","-0.0160855","tr|F5GYH1|F5GYH1_HUMAN;sp|Q8NC96|NECP1_HUMAN","tr|F5GYH1|F5GYH1_HUMAN;sp|Q8NC96|NECP1_HUMAN",3301,"F5GYH1","F5GYH1_HUMAN",null,null,"NECAP1"]
["24.6336","24.4116","24.8436","24.646",{"$nulls":3},"fatty acid beta-oxidation using acyl-CoA dehydrogenase;protein methylation;respiratory electron transport chain","electron transfer activity","cytosol;extracellular exosome;mitochondrial matrix",{"$nulls":3},16,16,16,"52.2","52.2","52.2","27.843",0,"64.442",2803800000,122,"0.563266",1,"-0.222247","-1.49578","sp|P38117|ETFB_HUMAN;tr|M0QY67|M0QY67_HUMAN","sp|P38117|ETFB_HUMAN;tr|M0QY67|M0QY67_HUMAN",1423,"P38117","ETFB_HUMAN","Electron transfer flavoprotein subunit beta {ECO:0000305}","eta-ETF {ECO:0000303|PubMed:8504797}","ETFB"]
["16.1206",1,"16.5657",1,{"$nulls":3},"cellular response to dexamethasone stimulus;establishment of protein localization;myotube cell development;negative regulation of protein kinase activity;nucleosome assembly;positive regulation of peptidyl-serine phosphorylation;positive regulation of transcription from RNA polymerase II promoter","histone-lysine N-methyltransferase activity;metal ion binding;RNA polymerase II core binding;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding","cytoplasm;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"4.7","4.7","4.7","49.097","0.0017076","3.4853",26752000,3,"0.00634348",1,"-0.222527","-0.0205086","sp|Q9H7B4|SMYD3_HUMAN;tr|B0QZA0|B0QZA0_HUMAN;tr|B0QZ88|B0QZ88_HUMAN","sp|Q9H7B4|SMYD3_HUMAN;tr|B0QZA0|B0QZA0_HUMAN;tr|B0QZ88|B0QZ88_HUMAN",4240,"Q9H7B4","SMYD3_HUMAN","Histone-lysine N-methyltransferase SMYD3",null,"SMYD3"]
["23.7787","23.8532","23.9203","24.1568",{"$nulls":3},"immune response;inosine catabolic process;interleukin-2 secretion;NAD biosynthesis via nicotinamide riboside salvage pathway;neutrophil degranulation;nicotinamide riboside catabolic process;nucleobase-containing compound metabolic process;positive regulation of alpha-beta T cell differentiation;positive regulation of T cell proliferation;purine nucleotide catabolic process;purine-containing compound salvage;response to drug;urate biosynthetic process","drug binding;nucleoside binding;phosphate ion binding;purine nucleobase binding;purine-nucleoside phosphorylase activity","cytoplasm;cytoskeleton;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;intracellular;nucleus;secretory granule lumen","Metabolic pathways;Nicotinate and nicotinamide metabolism;Purine metabolism;Pyrimidine metabolism",null,null,15,15,15,"70.9","70.9","70.9","32.118",0,"272.33",2403900000,132,"0.668956",1,"-0.222626","-1.79614","sp|P00491|PNPH_HUMAN;tr|G3V5M2|G3V5M2_HUMAN;tr|G3V2H3|G3V2H3_HUMAN;tr|G3V393|G3V393_HUMAN","sp|P00491|PNPH_HUMAN;tr|G3V5M2|G3V5M2_HUMAN",802,"P00491","PNPH_HUMAN","Purine nucleoside phosphorylase","NP","PNP"]
["17.5741","19.5532","18.4594","19.1183",{"$nulls":3},"attachment of GPI anchor to protein;protein localization to cell surface","cysteine-type peptidase activity;GPI-anchor transamidase activity;protein disulfide isomerase activity","endoplasmic reticulum membrane;GPI-anchor transamidase complex;integral component of endoplasmic reticulum membrane;membrane","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways",null,null,4,4,4,"13.7","13.7","13.7","45.251",0,"14.04",88446000,13,"0.0710745",1,"-0.225244","-0.215972","sp|Q92643|GPI8_HUMAN;tr|B1AK81|B1AK81_HUMAN;tr|A6NEM5|A6NEM5_HUMAN;tr|S4R3M5|S4R3M5_HUMAN","sp|Q92643|GPI8_HUMAN;tr|B1AK81|B1AK81_HUMAN;tr|A6NEM5|A6NEM5_HUMAN",3513,"Q92643","GPI8_HUMAN","GPI-anchor transamidase","PI transamidase","PIGK"]
["21.8385","21.9662","22.4483","21.8069",{"$nulls":3},"cell differentiation;nervous system development",null,"cytoplasm;cytosol;microtubule;microtubule cytoskeleton",{"$nulls":3},11,11,11,"48.8","48.8","48.8","27.325",0,"47.646",567230000,41,"0.250245",1,"-0.225287","-0.688988","sp|Q99426|TBCB_HUMAN;tr|K7EP07|K7EP07_HUMAN;tr|K7EK42|K7EK42_HUMAN;tr|K7EL99|K7EL99_HUMAN;tr|K7EQH0|K7EQH0_HUMAN;tr|K7ER04|K7ER04_HUMAN","sp|Q99426|TBCB_HUMAN;tr|K7EP07|K7EP07_HUMAN;tr|K7EK42|K7EK42_HUMAN",3840,"Q99426","TBCB_HUMAN","Tubulin-folding cofactor B",null,"TBCB"]
["24.0604","24.0879","24.2084","24.3915",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;apoptotic process;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of G1/S transition of mitotic cell cycle;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of proteasomal protein catabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;Wnt signaling pathway, planar cell polarity pathway","endopeptidase activator activity;identical protein binding;MDM2/MDM4 family protein binding;p53 binding","cytoplasm;cytosol;membrane;nucleoplasm;nucleus;proteasome activator complex;proteasome complex","Antigen processing and presentation;Hepatitis C;Proteasome",null,null,13,13,3,"62.2","62.2","24.8","29.506",0,"117.36",2007200000,64,"0.869952",1,"-0.22579","-2.43894","sp|P61289|PSME3_HUMAN;tr|K9J957|K9J957_HUMAN;tr|B3KQ25|B3KQ25_HUMAN;tr|K7ENH2|K7ENH2_HUMAN;tr|A0A087WTV2|A0A087WTV2_HUMAN;tr|K7EMD0|K7EMD0_HUMAN;tr|K7EPX6|K7EPX6_HUMAN;tr|K7EKR3|K7EKR3_HUMAN;tr|B7Z8D3|B7Z8D3_HUMAN","sp|P61289|PSME3_HUMAN;tr|K9J957|K9J957_HUMAN;tr|B3KQ25|B3KQ25_HUMAN;tr|K7ENH2|K7ENH2_HUMAN;tr|A0A087WTV2|A0A087WTV2_HUMAN",1842,"P61289","PSME3_HUMAN","Proteasome activator complex subunit 3",null,"PSME3"]
["16.9983","17.6751","17.3276","17.7994",{"$nulls":3},"cell adhesion;cellular protein metabolic process;endodermal cell differentiation;extracellular matrix organization;neuron projection development;neuronal-glial interaction involved in cerebral cortex radial glia guided migration;odontogenesis;positive regulation of cell migration;positive regulation of epithelial cell proliferation;post-translational protein modification;substrate adhesion-dependent cell spreading","extracellular matrix structural constituent;structural molecule activity","basement membrane;endoplasmic reticulum lumen;extracellular exosome;extracellular matrix;extracellular region;extracellular space;laminin-1 complex;laminin-10 complex;laminin-2 complex;laminin-8 complex;perinuclear region of cytoplasm","Amoebiasis;ECM-receptor interaction;Focal adhesion;Human papillomavirus infection;Pathways in cancer;PI3K-Akt signaling pathway;Small cell lung cancer;Toxoplasmosis",null,null,12,12,12,"9.1","9.1","9.1","198.04",0,"38.276",123040000,26,"0.195363",1,"-0.226758","-0.549664","sp|P07942|LAMB1_HUMAN;tr|G3XAI2|G3XAI2_HUMAN;tr|E7EPA6|E7EPA6_HUMAN","sp|P07942|LAMB1_HUMAN;tr|G3XAI2|G3XAI2_HUMAN",908,"P07942","LAMB1_HUMAN","Laminin subunit beta-1",null,"LAMB1"]
["24.809","24.9724","25.0988","25.1374",{"$nulls":3},"response to stress","chaperone binding;Hsp70 protein binding;protein C-terminus binding;RNA binding","cytosol;Golgi apparatus;myelin sheath;nucleus;protein complex","Prion diseases",null,null,35,35,35,60,60,60,"62.639",0,"323.31",10449000000,288,"0.944937",1,"-0.22742","-2.70911","sp|P31948|STIP1_HUMAN;tr|F5H783|F5H783_HUMAN;tr|F5GXD8|F5GXD8_HUMAN;tr|H0YGI8|H0YGI8_HUMAN","sp|P31948|STIP1_HUMAN",1342,"P31948","STIP1_HUMAN","Stress-induced-phosphoprotein 1","TI1","STIP1"]
["20.591","19.8261","20.7095","20.1645",{"$nulls":3},"protein folding","ATP binding","cytoplasm",{"$nulls":3},8,3,3,"34.1","17.2","17.2","29.736",0,"8.8175",211690000,23,"0.170842",1,"-0.228411","-0.486382","tr|S4R3N1|S4R3N1_HUMAN;sp|Q9Y3A3|PHOCN_HUMAN;tr|B4DM50|B4DM50_HUMAN","tr|S4R3N1|S4R3N1_HUMAN",5307,"S4R3N1","S4R3N1_HUMAN",null,null,"HSPE1-MOB4"]
["22.6149","22.2107","22.7052","22.5796",{"$nulls":3},"cellular response to gamma radiation;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;negative regulation of cell death;regulation of ion transmembrane transport","voltage-gated ion channel activity","extracellular exosome;integral component of membrane;nuclear outer membrane;sarcoplasmic reticulum membrane",{"$nulls":3},2,2,2,"8.6","8.6","8.6","26.21",0,"9.0916",596460000,33,"0.407487",1,"-0.229598","-1.08498","sp|Q9BVC6|TM109_HUMAN","sp|Q9BVC6|TM109_HUMAN",4007,"Q9BVC6","TM109_HUMAN","Transmembrane protein 109",null,"TMEM109"]
["21.6708","20.5844","21.6702","21.0446",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome;mitochondrion",{"$nulls":3},13,13,13,"33.6","33.6","33.6","48.117",0,"33.695",833690000,60,"0.125487",1,"-0.229796","-0.366622","sp|Q9BZE1|RM37_HUMAN;tr|S4R369|S4R369_HUMAN;tr|A6NHR2|A6NHR2_HUMAN;tr|H0Y4J2|H0Y4J2_HUMAN","sp|Q9BZE1|RM37_HUMAN;tr|S4R369|S4R369_HUMAN;tr|A6NHR2|A6NHR2_HUMAN;tr|H0Y4J2|H0Y4J2_HUMAN",4073,"Q9BZE1","RM37_HUMAN","39S ribosomal protein L37, mitochondrial","37mt;RP-L37","MRPL37"]
["19.613","17.7153","19.475","18.3136",{"$nulls":3},"adenosine to inosine editing;dITP catabolic process;IDP catabolic process;mRNA catabolic process;negative regulation of rRNA processing;nucleobase-containing small molecule catabolic process;positive regulation of cell cycle process;positive regulation of cell proliferation;positive regulation of double-strand break repair;snoRNA catabolic process;XDP catabolic process","cobalt ion binding;dIDP diphosphatase activity;dITP diphosphatase activity;GTP binding;identical protein binding;IDP phosphatase activity;ITP binding;m7G(5')pppN diphosphatase activity;magnesium ion binding;manganese ion binding;metalloexopeptidase activity;mRNA binding;nucleotide phosphatase activity, acting on free nucleotides;protein homodimerization activity;snoRNA binding;XTP binding","cytoplasm;nucleolus;nucleoplasm;nucleus","Metabolic pathways;Purine metabolism;RNA degradation",null,null,3,3,2,"23.6","23.6","17.9","21.273","0.00025038","6.3931",66763000,9,"0.067903",1,"-0.230141","-0.206875","sp|Q96DE0|NUD16_HUMAN","sp|Q96DE0|NUD16_HUMAN",3651,"Q96DE0","NUD16_HUMAN","U8 snoRNA-decapping enzyme",null,"NUDT16"]
["22.7505","23.3104","22.95","23.572",{"$nulls":9},7,7,4,28,28,"17.2","34.684",0,"34.833",961900000,36,"0.195894",1,"-0.230565","-0.551025","tr|H3BLU7|H3BLU7_HUMAN;sp|O43488|ARK72_HUMAN;tr|H7C5H7|H7C5H7_HUMAN","tr|H3BLU7|H3BLU7_HUMAN;sp|O43488|ARK72_HUMAN",404,"H3BLU7","H3BLU7_HUMAN",null,null,"AKR7A2"]
["17.6352","17.6894","17.6183","18.1687",{"$nulls":3},"embryonic organ development;endocytosis;female pregnancy;in utero embryonic development;membrane organization;negative regulation of epidermal growth factor receptor signaling pathway;Notch signaling pathway","lipid binding","clathrin-coated pit;cytosol;nucleus;plasma membrane","Endocytosis",null,null,2,2,2,"8.2","8.2","8.2","60.293",0,"9.4196",28327000,4,"0.308813",1,"-0.231193","-0.836008","sp|Q9Y6I3|EPN1_HUMAN","sp|Q9Y6I3|EPN1_HUMAN",5096,"Q9Y6I3","EPN1_HUMAN","Epsin-1",null,"EPN1"]
["17.4844","18.225","17.6994","18.4748",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;protein sumoylation;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;tRNA export from nucleus;viral process;viral transcription","protein dimerization activity","endoplasmic reticulum membrane;host cell;integral component of membrane;membrane;nuclear envelope;nuclear membrane;nuclear pore","RNA transport",null,null,13,13,13,"8.8","8.8","8.8","205.11",0,"30.558",195980000,28,"0.15065",1,"-0.232448","-0.433567","sp|Q8TEM1|PO210_HUMAN","sp|Q8TEM1|PO210_HUMAN",3397,"Q8TEM1","PO210_HUMAN","Nuclear pore membrane glycoprotein 210","uclear pore protein gp210","NUP210"]
["17.3502","17.5828","18.3427","17.0598",{"$nulls":5},"U2 snRNP",{"$nulls":3},3,3,3,"11.7","11.7","11.7","38.946","0.00023725","5.2456",25947000,6,"0.123078",1,"-0.234774","-0.360138","sp|Q96F63|CCD97_HUMAN","sp|Q96F63|CCD97_HUMAN",3681,"Q96F63","CCD97_HUMAN","Coiled-coil domain-containing protein 97",null,"CCDC97"]
["22.7976","22.0924","23.04","22.3208",{"$nulls":3},"chaperone-mediated protein folding","FK506 binding;peptidyl-prolyl cis-trans isomerase activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome",{"$nulls":3},3,3,3,"38.7","38.7","38.7","15.649",0,"16.859",392040000,11,"0.163545",1,"-0.235379","-0.467377","sp|P26885|FKBP2_HUMAN;tr|F5H0N4|F5H0N4_HUMAN","sp|P26885|FKBP2_HUMAN",1246,"P26885","FKBP2_HUMAN","Peptidyl-prolyl cis-trans isomerase FKBP2","PIase FKBP2","FKBP2"]
["21.3147","21.3671","21.6906","21.4624",{"$nulls":3},"mitochondrial translational elongation","GTP binding;GTPase activity;RNA binding;translation elongation factor activity","mitochondrial matrix;mitochondrion",{"$nulls":3},17,17,17,"30.2","30.2","30.2","83.471",0,"59.232",1078100000,67,"0.740581",1,"-0.235584","-2.01314","sp|Q96RP9|EFGM_HUMAN;tr|C9IZ01|C9IZ01_HUMAN;tr|F8WAU4|F8WAU4_HUMAN;tr|C9JA25|C9JA25_HUMAN","sp|Q96RP9|EFGM_HUMAN;tr|C9IZ01|C9IZ01_HUMAN;tr|F8WAU4|F8WAU4_HUMAN",3805,"Q96RP9","EFGM_HUMAN","Elongation factor G, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03061}","F-Gmt {ECO:0000255|HAMAP-Rule:MF_03061}","GFM1"]
["20.485","20.8858","20.6094","21.2358",{"$nulls":3},"phosphate-containing compound metabolic process","inorganic diphosphatase activity;magnesium ion binding","cytoplasm",{"$nulls":3},2,1,1,"38.1","12.7","12.7","7.4054","0.0065359","2.564",38140000,5,"0.229958",1,"-0.237145","-0.637767","tr|A0A0C4DGB9|A0A0C4DGB9_HUMAN","tr|A0A0C4DGB9|A0A0C4DGB9_HUMAN",5150,"A0A0C4DGB9","A0A0C4DGB9_HUMAN",null,null,"PPA2"]
["25.8047","25.6204","26.1901","25.711",{"$nulls":3},"epithelial cell differentiation;platelet degranulation","cadherin binding","cytosol;extracellular exosome;extracellular region;vesicle",{"$nulls":3},13,13,13,"79.9","79.9","79.9","22.391",0,"266.38",6219100000,164,"0.345233",1,"-0.238025","-0.927424","sp|P37802|TAGL2_HUMAN;tr|X6RJP6|X6RJP6_HUMAN;tr|C9J5W6|C9J5W6_HUMAN;sp|Q9UI15|TAGL3_HUMAN","sp|P37802|TAGL2_HUMAN;tr|X6RJP6|X6RJP6_HUMAN",1421,"P37802","TAGL2_HUMAN","Transgelin-2",null,"TAGLN2"]
["28.8206","28.7352","28.9818","29.0524",{"$nulls":3},"canonical glycolysis;gluconeogenesis;negative regulation of cell growth;negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of ATP biosynthetic process;positive regulation of muscle contraction;positive regulation of plasminogen activation;response to virus;transcription, DNA-templated","cadherin binding;GTPase binding;magnesium ion binding;phosphopyruvate hydratase activity;protein homodimerization activity;RNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","cell cortex region;cell surface;cytoplasm;cytosol;extracellular exosome;extracellular space;M band;membrane;nucleus;phosphopyruvate hydratase complex;plasma membrane","Biosynthesis of amino acids;Carbon metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Metabolic pathways;RNA degradation",null,null,27,27,24,"75.3","75.3","66.8","47.168",0,"323.31",95524000000,1089,"1.30386",1,"-0.239201","-4.3178","sp|P06733|ENOA_HUMAN;tr|K7EM90|K7EM90_HUMAN","sp|P06733|ENOA_HUMAN",880,"P06733","ENOA_HUMAN","Alpha-enolase",null,"ENO1"]
["24.3836","23.8218","24.4478","24.2375",{"$nulls":3},"nucleosome assembly","nucleosome binding;RNA binding;unfolded protein binding","cytoplasm;nucleus",{"$nulls":3},13,13,11,"41.3","41.3","38.4","42.823",0,"285.21",3031300000,143,"0.294364",1,"-0.239891","-0.799787","sp|Q99733|NP1L4_HUMAN;tr|C9J6D1|C9J6D1_HUMAN;tr|A8MXH2|A8MXH2_HUMAN;tr|C9JZI7|C9JZI7_HUMAN;tr|E9PS34|E9PS34_HUMAN;tr|E9PNJ7|E9PNJ7_HUMAN;tr|E9PNW0|E9PNW0_HUMAN;tr|E9PJJ2|E9PJJ2_HUMAN;tr|E9PKT8|E9PKT8_HUMAN;tr|E9PKI2|E9PKI2_HUMAN;tr|E9PP22|E9PP22_HUMAN;tr|H0YCI4|H0YCI4_HUMAN;tr|C9J1B1|C9J1B1_HUMAN","sp|Q99733|NP1L4_HUMAN;tr|C9J6D1|C9J6D1_HUMAN;tr|A8MXH2|A8MXH2_HUMAN;tr|C9JZI7|C9JZI7_HUMAN;tr|E9PS34|E9PS34_HUMAN;tr|E9PNJ7|E9PNJ7_HUMAN;tr|E9PNW0|E9PNW0_HUMAN;tr|E9PJJ2|E9PJJ2_HUMAN;tr|E9PKT8|E9PKT8_HUMAN",3878,"Q99733","NP1L4_HUMAN","Nucleosome assembly protein 1-like 4",null,"NAP1L4"]
["26.0799","26.0302","26.3228","26.2685",{"$nulls":3},"brain development;L-serine biosynthetic process","electron transfer activity;L-malate dehydrogenase activity;NAD binding;phosphoglycerate dehydrogenase activity","cytosol;extracellular exosome","Biosynthesis of amino acids;Carbon metabolism;Cysteine and methionine metabolism;Glycine, serine and threonine metabolism;Metabolic pathways",null,null,26,26,26,"60.4","60.4","60.4","56.65",0,"323.31",18455000000,447,"1.64587",1,"-0.24059","-6.53845","sp|O43175|SERA_HUMAN;tr|Q5SZU1|Q5SZU1_HUMAN","sp|O43175|SERA_HUMAN;tr|Q5SZU1|Q5SZU1_HUMAN",379,"O43175","SERA_HUMAN","D-3-phosphoglycerate dehydrogenase",{"$f":"-PGDH","v":{"$error":"#NAME?"}},"PHGDH"]
["17.5041","17.5084","17.8493","17.6461",{"$nulls":4},"actin binding;calcium ion binding;microtubule binding","cytoskeleton",{"$nulls":3},46,45,45,"8.8","8.7","8.7","856.87",0,"154.89",835230000,129,"0.85175",1,"-0.241437","-2.3761","tr|H3BPE1|H3BPE1_HUMAN;tr|H3BQK9|H3BQK9_HUMAN;sp|Q9UPN3|MACF1_HUMAN;tr|H0Y390|H0Y390_HUMAN;tr|E9PNZ4|E9PNZ4_HUMAN;tr|H0YD69|H0YD69_HUMAN;tr|E9PLY5|E9PLY5_HUMAN;tr|E9PLY0|E9PLY0_HUMAN;tr|H0Y314|H0Y314_HUMAN;tr|H0Y6T5|H0Y6T5_HUMAN;tr|H0Y4F5|H0Y4F5_HUMAN","tr|H3BPE1|H3BPE1_HUMAN;tr|H3BQK9|H3BQK9_HUMAN;sp|Q9UPN3|MACF1_HUMAN;tr|H0Y390|H0Y390_HUMAN",5263,"H3BPE1","H3BPE1_HUMAN",null,null,"MACF1"]
["18.9693","19.3921","19.4201","19.4262",{"$nulls":3},"abscission;cell separation after cytokinesis;endosomal transport;macroautophagy;mitotic cytokinesis checkpoint;mitotic metaphase plate congression;multivesicular body assembly;negative regulation of cytokinesis;nucleus organization;positive regulation of viral release from host cell;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;regulation of viral process;ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;vacuolar transport;viral budding via host ESCRT complex;viral life cycle","protein homodimerization activity","cytosol;ESCRT III complex;extracellular exosome;Flemming body;late endosome membrane;midbody","Endocytosis;Necroptosis",null,null,4,4,4,24,24,24,"26.41",0,"11.354",75415000,15,"0.431643",1,"-0.242469","-1.14686","sp|Q96CF2|CHM4C_HUMAN","sp|Q96CF2|CHM4C_HUMAN",3633,"Q96CF2","CHM4C_HUMAN","Charged multivesicular body protein 4c",null,"CHMP4C"]
["20.2857","19.66","20.6133","19.8189",{"$nulls":3},"mRNA splicing, via spliceosome;RNA metabolic process","RNA binding","cytosol;intracellular ribonucleoprotein complex;membrane;nucleoplasm;nucleus",{"$nulls":3},8,4,4,"27.6","15.1","15.1","49.263",0,"26.003",239230000,5,"0.16883",1,"-0.243277","-0.48115","sp|P55795|HNRH2_HUMAN","sp|P55795|HNRH2_HUMAN",1771,"P55795","HNRH2_HUMAN","Heterogeneous nuclear ribonucleoprotein H2","nRNP H2","HNRNPH2"]
["23.3122","22.8994","23.5784","23.1219",{"$nulls":3},"activation of MAPK activity;basophil activation involved in immune response;diadenosine tetraphosphate biosynthetic process;ERK1 and ERK2 cascade;lysyl-tRNA aminoacylation;negative regulation of cell proliferation;positive regulation of cytokine production involved in inflammatory response;positive regulation of cytokine secretion involved in immune response;positive regulation of ERK1 and ERK2 cascade;positive regulation of macrophage activation;positive regulation of macrophage chemotaxis;positive regulation of metallopeptidase activity;positive regulation of p38MAPK cascade;positive regulation of transcription, DNA-templated;response to X-ray;tRNA aminoacylation for protein translation;tRNA processing;tumor necrosis factor-mediated signaling pathway;viral process","amino acid binding;ATP adenylyltransferase activity;ATP binding;identical protein binding;lysine-tRNA ligase activity;protein homodimerization activity;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytosol;extracellular space;mitochondrial matrix;mitochondrion;nucleus;plasma membrane","Aminoacyl-tRNA biosynthesis",null,null,32,32,32,"60.3","60.3","60.3","68.047",0,"300.08",7087800000,480,"0.292055",1,"-0.244338","-0.793997","sp|Q15046|SYK_HUMAN;tr|H3BVA8|H3BVA8_HUMAN;tr|J3KRL2|J3KRL2_HUMAN;tr|H3BPV7|H3BPV7_HUMAN;tr|H3BRC9|H3BRC9_HUMAN","sp|Q15046|SYK_HUMAN",2436,"Q15046","SYK_HUMAN","Lysine--tRNA ligase",null,"KARS"]
["23.0883","22.8496","23.2747","23.1534",{"$nulls":3},"methylation;one-carbon metabolic process;S-adenosylmethionine biosynthetic process","enzyme binding;methionine adenosyltransferase regulator activity","cytosol;extracellular exosome;intracellular;methionine adenosyltransferase complex;mitochondrion;nucleus","Biosynthesis of amino acids;Cysteine and methionine metabolism;Metabolic pathways",null,null,11,11,11,"42.2","42.2","42.2","37.551",0,"119.32",1454500000,74,"0.68069",1,"-0.245131","-1.83088","sp|Q9NZL9|MAT2B_HUMAN;tr|H7C0X7|H7C0X7_HUMAN;tr|E5RJR3|E5RJR3_HUMAN","sp|Q9NZL9|MAT2B_HUMAN;tr|H7C0X7|H7C0X7_HUMAN",4596,"Q9NZL9","MAT2B_HUMAN","Methionine adenosyltransferase 2 subunit beta",null,"MAT2B"]
["18.5349","17.1644","19.4659","16.7243",{"$nulls":3},"acylglycerol acyl-chain remodeling;diacylglycerol metabolic process;fatty acid homeostasis;lipid storage;long-chain fatty-acyl-CoA metabolic process;neutrophil degranulation;triglyceride biosynthetic process;triglyceride metabolic process;very-low-density lipoprotein particle assembly","2-acylglycerol O-acyltransferase activity;diacylglycerol O-acyltransferase activity;retinol O-fatty-acyltransferase activity;transferase activity, transferring acyl groups","endoplasmic reticulum membrane;integral component of membrane;plasma membrane;specific granule membrane","Fat digestion and absorption;Glycerolipid metabolism;Metabolic pathways;Retinol metabolism",null,null,8,8,8,"21.9","21.9","21.9","55.278",0,"70.518",557090000,51,"0.0518481",1,"-0.245463","-0.160164","sp|O75907|DGAT1_HUMAN;tr|A0A0A0MR74|A0A0A0MR74_HUMAN","sp|O75907|DGAT1_HUMAN;tr|A0A0A0MR74|A0A0A0MR74_HUMAN",624,"O75907","DGAT1_HUMAN","Diacylglycerol O-acyltransferase 1",null,"DGAT1"]
["22.8733","24.0613","23.2288","24.1992",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to organic cyclic compound;response to organonitrogen compound;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;membrane;nucleoplasm;nucleus;proteasome complex;proteasome core complex;proteasome core complex, beta-subunit complex","Proteasome",null,null,6,6,6,"37.8","37.8","37.8","22.836",0,"76.948",1137100000,43,"0.108892",1,"-0.246697","-0.32164","sp|P49721|PSB2_HUMAN;tr|A0A087WVV1|A0A087WVV1_HUMAN","sp|P49721|PSB2_HUMAN;tr|A0A087WVV1|A0A087WVV1_HUMAN",1591,"P49721","PSB2_HUMAN","Proteasome subunit beta type-2",null,"PSMB2"]
["20.5047","20.3825","20.6158","20.7662",{"$nulls":3},"generation of precursor metabolites and energy;glycogen biosynthetic process;glycogen metabolic process","1,4-alpha-glucan branching enzyme activity;1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis);carbohydrate binding;cation binding;hydrolase activity, hydrolyzing O-glycosyl compounds","cytosol;extracellular exosome","Metabolic pathways;Starch and sucrose metabolism",null,null,6,6,6,"12.3","12.3","12.3","80.473",0,34,395910000,16,"0.901955",1,"-0.247366","-2.55197","sp|Q04446|GLGB_HUMAN;tr|E9PGM4|E9PGM4_HUMAN","sp|Q04446|GLGB_HUMAN;tr|E9PGM4|E9PGM4_HUMAN",2089,"Q04446","GLGB_HUMAN","1,4-alpha-glucan-branching enzyme",null,"GBE1"]
["21.7243","21.1706","21.8398","21.5527",{"$nulls":3},"carnitine metabolic process;carnitine shuttle;cellular response to fatty acid;circadian rhythm;eating behavior;epithelial cell differentiation;fatty acid beta-oxidation;glucose metabolic process;long-chain fatty acid metabolic process;positive regulation of fatty acid beta-oxidation;protein homooligomerization;regulation of insulin secretion;regulation of lipid metabolic process;response to drug;response to organic cyclic compound;triglyceride metabolic process","carnitine O-palmitoyltransferase activity;identical protein binding;palmitoleoyltransferase activity","integral component of mitochondrial outer membrane;membrane;mitochondrial inner membrane;mitochondrial outer membrane;mitochondrion","Adipocytokine signaling pathway;AMPK signaling pathway;Fatty acid degradation;Fatty acid metabolism;Glucagon signaling pathway;Insulin resistance;PPAR signaling pathway;Thermogenesis",null,null,28,28,28,"42.7","42.7","42.7","88.367",0,"272.43",3887900000,260,"0.293611",1,"-0.248832","-0.797898","sp|P50416|CPT1A_HUMAN;tr|H3BP22|H3BP22_HUMAN;tr|H3BUV7|H3BUV7_HUMAN;tr|H3BUJ0|H3BUJ0_HUMAN;tr|H3BMD2|H3BMD2_HUMAN","sp|P50416|CPT1A_HUMAN",1624,"P50416","CPT1A_HUMAN","Carnitine O-palmitoyltransferase 1, liver isoform","PT1-L","CPT1A"]
["23.0201","22.007","23.1711","22.3541",{"$nulls":9},14,14,14,"34.9","34.9","34.9","54.719",0,"156.4",1925600000,88,"0.131498",1,"-0.249065","-0.382744","tr|F6TLX2|F6TLX2_HUMAN;sp|Q9HC38|GLOD4_HUMAN;tr|I3L3Q4|I3L3Q4_HUMAN;tr|I3L1I0|I3L1I0_HUMAN;tr|I3L1F4|I3L1F4_HUMAN","tr|F6TLX2|F6TLX2_HUMAN;sp|Q9HC38|GLOD4_HUMAN;tr|I3L3Q4|I3L3Q4_HUMAN",5227,"F6TLX2","F6TLX2_HUMAN",null,null,"GLOD4"]
["18.5247","18.7134","18.5686","19.1708",{"$nulls":3},"IRE1-mediated unfolded protein response;liver development;multicellular organism aging;nitrogen compound metabolic process;posttranslational protein targeting to endoplasmic reticulum membrane;posttranslational protein targeting to membrane, translocation;protein targeting to membrane;renal system development;SRP-dependent cotranslational protein targeting to membrane","protein transporter activity;receptor activity;RNA binding","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane","Protein export;Protein processing in endoplasmic reticulum",null,null,10,10,10,"16.8","16.8","16.8","87.996",0,"38.749",317180000,51,"0.292146",1,"-0.250649","-0.794227","sp|Q9UGP8|SEC63_HUMAN","sp|Q9UGP8|SEC63_HUMAN",4708,"Q9UGP8","SEC63_HUMAN","Translocation protein SEC63 homolog",null,"SEC63"]
["20.9862","20.0559","21.2718","20.2738",{"$nulls":3},"ATP metabolic process;dATP metabolic process;dGDP biosynthetic process;dGMP metabolic process;GDP biosynthetic process;GDP-mannose metabolic process;glycoprotein transport;nucleobase-containing small molecule interconversion;purine nucleotide metabolic process","ATP binding;guanylate kinase activity","cytosol","Metabolic pathways;Purine metabolism",null,null,8,8,8,"50.8","50.8","50.8","21.725",0,"22.741",231450000,25,"0.126376",1,"-0.251734","-0.369012","sp|Q16774|KGUA_HUMAN;tr|B1ANH5|B1ANH5_HUMAN;tr|B1ANH0|B1ANH0_HUMAN;tr|B1ANH6|B1ANH6_HUMAN;tr|B1ANH2|B1ANH2_HUMAN;tr|B1ANG9|B1ANG9_HUMAN;tr|B1ANH3|B1ANH3_HUMAN","sp|Q16774|KGUA_HUMAN;tr|B1ANH5|B1ANH5_HUMAN;tr|B1ANH0|B1ANH0_HUMAN;tr|B1ANH6|B1ANH6_HUMAN;tr|B1ANH2|B1ANH2_HUMAN;tr|B1ANG9|B1ANG9_HUMAN;tr|B1ANH3|B1ANH3_HUMAN",2571,"Q16774","KGUA_HUMAN","Guanylate kinase",null,"GUK1"]
["14.6318",1,"15.137",1,{"$nulls":3},"regulation of transcription from RNA polymerase II promoter;regulation of transcription, DNA-templated;transcription initiation from RNA polymerase II promoter","transcription coactivator activity","nucleoplasm;transcription factor complex",{"$nulls":3},15,15,15,"12.3","12.3","12.3","156.47",0,"41.845",311170000,49,"0.00797107",1,"-0.252594","-0.0257241","sp|Q9ULK4|MED23_HUMAN;tr|Q5JWT2|Q5JWT2_HUMAN","sp|Q9ULK4|MED23_HUMAN;tr|Q5JWT2|Q5JWT2_HUMAN",4820,"Q9ULK4","MED23_HUMAN","Mediator of RNA polymerase II transcription subunit 23",null,"MED23"]
["23.3878","23.3441","23.5424","23.6957",{"$nulls":3},"apoptotic process;negative regulation of cell proliferation;positive regulation of aminoacyl-tRNA ligase activity;positive regulation of neuron death;positive regulation of protein ubiquitination;protein complex assembly;tRNA aminoacylation for protein translation;Type II pneumocyte differentiation","protein complex scaffold activity","aminoacyl-tRNA synthetase multienzyme complex;cytosol;membrane;nucleus",{"$nulls":3},12,12,4,"58.4","58.4","23.4","35.348",0,"323.31",4503300000,151,"1.06272",1,"-0.253091","-3.17431","sp|Q13155|AIMP2_HUMAN;tr|A8MU58|A8MU58_HUMAN","sp|Q13155|AIMP2_HUMAN;tr|A8MU58|A8MU58_HUMAN",2214,"Q13155","AIMP2_HUMAN","Aminoacyl tRNA synthase complex-interacting multifunctional protein 2",null,"AIMP2"]
["20.201","20.4525","20.5265","20.636",{"$nulls":3},"cornification;epithelial cell morphogenesis involved in placental branching;keratinocyte differentiation;neural tube closure;proteolysis","endopeptidase activity;serine-type endopeptidase activity;serine-type peptidase activity","basolateral plasma membrane;extracellular exosome;extrinsic component of plasma membrane;integral component of plasma membrane;plasma membrane","MicroRNAs in cancer",null,null,11,11,11,"17.9","17.9","17.9","94.769",0,"40.297",511170000,53,"0.688881",1,"-0.254509","-1.85531","sp|Q9Y5Y6|ST14_HUMAN","sp|Q9Y5Y6|ST14_HUMAN",5066,"Q9Y5Y6","ST14_HUMAN","Suppressor of tumorigenicity 14 protein",null,"ST14"]
["19.7548","21.7472","20.4979","21.5161",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;autophagosome maturation;autophagosome membrane docking;membrane organization;mucus secretion;negative regulation of secretion by cell;neutrophil degranulation;positive regulation of histamine secretion by mast cell;post-Golgi vesicle-mediated transport;protein transport;regulation of protein localization to plasma membrane;vesicle fusion;viral entry into host cell","chloride channel inhibitor activity;SNAP receptor activity;SNARE binding","azurophil granule membrane;clathrin-coated vesicle membrane;cytoplasm;cytosol;early endosome;early endosome membrane;extracellular exosome;integral component of membrane;late endosome membrane;lysosomal membrane;membrane;mucin granule;perinuclear region of cytoplasm;phagocytic vesicle membrane;plasma membrane;recycling endosome;recycling endosome membrane;secretory granule membrane;SNARE complex;specific granule membrane;synaptic vesicle;tertiary granule membrane;vesicle","Autophagy - animal;Platelet activation;SNARE interactions in vesicular transport",null,null,5,5,5,47,47,47,"11.438",0,"15.389",308720000,21,"0.0755936",1,"-0.256039","-0.228866","sp|Q9BV40|VAMP8_HUMAN;tr|B8ZZT4|B8ZZT4_HUMAN;tr|C9JXZ5|C9JXZ5_HUMAN","sp|Q9BV40|VAMP8_HUMAN;tr|B8ZZT4|B8ZZT4_HUMAN",3998,"Q9BV40","VAMP8_HUMAN","Vesicle-associated membrane protein 8 {ECO:0000303|PubMed:12130530}","AMP-8 {ECO:0000303|PubMed:12130530}","VAMP8"]
["24.5967","23.3288","24.6876","23.7544",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;histone exchange;inner ear development;negative regulation of cell differentiation;nucleosome assembly;palate development;positive regulation of protein export from nucleus;vasculature development;ventricular system development","histone binding;RNA polymerase binding","cytoplasm;extracellular exosome;nucleus",{"$nulls":3},6,5,5,"22.3","15.9","15.9","28.787",0,"20.686",1458100000,61,"0.111234",1,"-0.258211","-0.328033","sp|Q92688|AN32B_HUMAN","sp|Q92688|AN32B_HUMAN",3518,"Q92688","AN32B_HUMAN","Acidic leucine-rich nuclear phosphoprotein 32 family member B",null,"ANP32B"]
["20.2078","19.8586","20.0431","20.5408",{"$nulls":3},"cell proliferation;mitochondrial calcium ion transmembrane transport;mitochondrial protein catabolic process;mitochondrial protein processing;mitochondrion organization;negative regulation of apoptotic process;protein hexamerization;protein quality control for misfolded or incompletely synthesized proteins","ATP binding;ATP-dependent peptidase activity;metal ion binding;metalloendopeptidase activity;metallopeptidase activity","integral component of membrane;membrane;mitochondrial inner membrane;mitochondrion;nuclear body",{"$nulls":3},21,21,21,"36.1","36.1","36.1","86.454",0,"312.42",3071500000,213,"0.314913",1,"-0.258746","-0.851301","sp|Q96TA2|YMEL1_HUMAN;tr|Q96I63|Q96I63_HUMAN;tr|R4GNA5|R4GNA5_HUMAN;tr|Q5T8D1|Q5T8D1_HUMAN;tr|Q5T8D2|Q5T8D2_HUMAN","sp|Q96TA2|YMEL1_HUMAN;tr|Q96I63|Q96I63_HUMAN",3838,"Q96TA2","YMEL1_HUMAN","ATP-dependent zinc metalloprotease YME1L1",null,"YME1L1"]
["22.4442","22.4466","22.6601","22.7483",{"$nulls":3},"DNA metabolic process;intracellular transport of virus;modulation by virus of host process;NLS-bearing protein import into nucleus;regulation of DNA recombination","histone deacetylase binding;nuclear localization sequence binding;protein transporter activity;RNA binding","cytoplasm;cytosol;host cell;membrane;nuclear pore;nucleoplasm","Influenza A",null,null,16,16,16,"46.7","46.7","46.7","57.861",0,"230.5",1644200000,167,"1.55533",1,"-0.258777","-5.86741","sp|P52292|IMA1_HUMAN;tr|J3QLL0|J3QLL0_HUMAN;tr|J3KS65|J3KS65_HUMAN;tr|J3QL07|J3QL07_HUMAN","sp|P52292|IMA1_HUMAN",1680,"P52292","IMA1_HUMAN","Importin subunit alpha-1",null,"KPNA2"]
["16.4295","19.14","17.0225","19.0666",{"$nulls":3},"cellular protein metabolic process;intracellular protein transport;vesicle-mediated transport","ADP-ribosylation factor binding","clathrin adaptor complex;clathrin-coated vesicle;early endosome membrane;endosome membrane;Golgi apparatus;trans-Golgi network","Lysosome",null,null,4,4,4,"15.8","15.8","15.8","67.15",0,"38.538",64757000,8,"0.0494292",1,"-0.259751","-0.153025","sp|Q9UJY4|GGA2_HUMAN;tr|H3BMN6|H3BMN6_HUMAN;tr|I3L2C4|I3L2C4_HUMAN;tr|H3BMM6|H3BMM6_HUMAN","sp|Q9UJY4|GGA2_HUMAN",4773,"Q9UJY4","GGA2_HUMAN","ADP-ribosylation factor-binding protein GGA2",null,"GGA2"]
["18.4534","18.3874","18.6691","18.6969",{"$nulls":3},"chromatin silencing;mitochondrion organization;negative regulation of cardiac muscle cell apoptotic process;negative regulation of reactive oxygen species metabolic process;peptidyl-lysine demalonylation;peptidyl-lysine desuccinylation;protein ADP-ribosylation;protein deacetylation;protein deglutarylation;protein demalonylation;protein desuccinylation;regulation of ketone biosynthetic process;response to nutrient levels","NAD+ ADP-ribosyltransferase activity;NAD+ binding;NAD-dependent protein deacetylase activity;protein-glutaryllysine deglutarylase activity;protein-malonyllysine demalonylase activity;protein-succinyllysine desuccinylase activity;zinc ion binding","cytosol;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial matrix;mitochondrion;nucleus",{"$nulls":3},2,2,2,"10.6","10.6","10.6","33.881","0.0002649","7.5553",56881000,14,"1.74241",1,"-0.26254","-7.33244","sp|Q9NXA8|SIR5_HUMAN","sp|Q9NXA8|SIR5_HUMAN",4541,"Q9NXA8","SIR5_HUMAN","NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}",null,"SIRT5"]
["16.4357","18.6531","17.7361","17.8799",{"$nulls":3},"cell cycle;cell division;DNA replication","DNA binding","nucleus",{"$nulls":3},4,4,3,"13.1","13.1","10.6","49.741",0,"9.3531",55761000,15,"0.0785509",1,"-0.263597","-0.237261","sp|Q6IQ49|SDE2_HUMAN","sp|Q6IQ49|SDE2_HUMAN",2825,"Q6IQ49","SDE2_HUMAN","Replication stress response regulator SDE2 {ECO:0000305}",null,"SDE2"]
["19.539","21.1409","19.5352","21.6738",{"$nulls":3},"bicarbonate transport;chloride ion homeostasis;one-carbon metabolic process","carbonate dehydratase activity;zinc ion binding","integral component of membrane;plasma membrane","Metabolic pathways;Nitrogen metabolism",null,null,3,3,3,"13.3","13.3","13.3","39.45",0,"24.043",265060000,14,"0.0648296",1,"-0.26455","-0.19802","sp|O43570|CAH12_HUMAN;tr|B3KUB4|B3KUB4_HUMAN","sp|O43570|CAH12_HUMAN;tr|B3KUB4|B3KUB4_HUMAN",408,"O43570","CAH12_HUMAN","Carbonic anhydrase 12",null,"CA12"]
["16.3947","15.7777","15.9906","16.7125",{"$nulls":5},"microtubule organizing center",{"$nulls":3},5,4,4,"7.2","6.4","6.4","112.28","0.00024643","6.0511",31342000,7,"0.198981",1,"-0.265378","-0.558935","tr|A0A0A0MRL8|A0A0A0MRL8_HUMAN;tr|A0A0A0MRL9|A0A0A0MRL9_HUMAN;tr|A0A087WVF8|A0A087WVF8_HUMAN;tr|A0A0A0MRM0|A0A0A0MRM0_HUMAN;tr|A0A0A0MRM1|A0A0A0MRM1_HUMAN;tr|A0A087WX83|A0A087WX83_HUMAN;tr|A0A075B749|A0A075B749_HUMAN;tr|E9PQG4|E9PQG4_HUMAN;tr|E9PL24|E9PL24_HUMAN;tr|A0A0C4DFQ0|A0A0C4DFQ0_HUMAN;sp|Q5VU43|MYOME_HUMAN;tr|A0A087WWI2|A0A087WWI2_HUMAN;tr|A0A087WYE4|A0A087WYE4_HUMAN;tr|E9PS60|E9PS60_HUMAN","tr|A0A0A0MRL8|A0A0A0MRL8_HUMAN;tr|A0A0A0MRL9|A0A0A0MRL9_HUMAN;tr|A0A087WVF8|A0A087WVF8_HUMAN;tr|A0A0A0MRM0|A0A0A0MRM0_HUMAN;tr|A0A0A0MRM1|A0A0A0MRM1_HUMAN;tr|A0A087WX83|A0A087WX83_HUMAN;tr|A0A075B749|A0A075B749_HUMAN;tr|E9PQG4|E9PQG4_HUMAN;tr|E9PL24|E9PL24_HUMAN;tr|A0A0C4DFQ0|A0A0C4DFQ0_HUMAN;sp|Q5VU43|MYOME_HUMAN",5125,"A0A0A0MRL8","A0A0A0MRL8_HUMAN",null,null,"PDE4DIP"]
["13.8903","14.7046","13.8817","15.2488",{"$nulls":3},"cell cycle;cellular response to DNA damage stimulus;cellular response to gamma radiation;cellular response to UV;DNA damage checkpoint;DNA repair;DNA replication;establishment of macromolecular complex localization to telomere;establishment of RNA localization to telomere;interstrand cross-link repair;multicellular organism development;negative regulation of DNA replication;peptidyl-serine phosphorylation;positive regulation of DNA damage response, signal transduction by p53 class mediator;positive regulation of telomerase catalytic core complex assembly;positive regulation of telomere maintenance via telomerase;protein autophosphorylation;protein localization to chromosome, telomeric region;regulation of cellular response to heat;regulation of signal transduction by p53 class mediator;replicative senescence;response to drug","ATP binding;DNA binding;MutLalpha complex binding;MutSalpha complex binding;protein kinase activity;protein serine/threonine kinase activity","chromosome;Golgi apparatus;nucleoplasm;PML body","Cell cycle;Cellular senescence;Fanconi anemia pathway;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;p53 signaling pathway",null,null,5,5,5,"2.6","2.6","2.6","301.36",0,"9.9102",511530000,20,"0.114391",1,"-0.267826","-0.336628","sp|Q13535|ATR_HUMAN;tr|H0Y9K2|H0Y9K2_HUMAN;tr|H0Y8R8|H0Y8R8_HUMAN;tr|H0Y8Y6|H0Y8Y6_HUMAN;tr|D6RFJ6|D6RFJ6_HUMAN","sp|Q13535|ATR_HUMAN",2274,"Q13535","ATR_HUMAN","Serine/threonine-protein kinase ATR",null,"ATR"]
["26.7159","25.7887","26.7358","26.3059",{"$nulls":3},"cotranslational protein targeting to membrane;neutrophil degranulation;protein targeting to ER;response to drug;SRP-dependent cotranslational protein targeting to membrane","7S RNA binding;endoplasmic reticulum signal peptide binding;RNA binding","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;nucleus;secretory granule lumen;signal recognition particle, endoplasmic reticulum targeting","Protein export",null,null,9,9,7,"67.6","67.6","41.2","14.57",0,"310.38",54309000000,712,"0.185966",1,"-0.268563","-0.525508","sp|P37108|SRP14_HUMAN;tr|H0YLA2|H0YLA2_HUMAN","sp|P37108|SRP14_HUMAN;tr|H0YLA2|H0YLA2_HUMAN",1418,"P37108","SRP14_HUMAN","Signal recognition particle 14 kDa protein","RP14","SRP14"]
["22.6681","22.5437","22.7743","22.9746",{"$nulls":3},"cellular response to epidermal growth factor stimulus;cellular response to insulin stimulus;cellular response to platelet-derived growth factor stimulus;cellular response to starvation;methionyl-tRNA aminoacylation;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;rRNA transcription;tRNA aminoacylation for protein translation","ATP binding;methionine-tRNA ligase activity;tRNA binding","aminoacyl-tRNA synthetase multienzyme complex;cytoplasm;cytosol;extracellular exosome;membrane;nucleolus","Aminoacyl-tRNA biosynthesis;Metabolic pathways;Selenocompound metabolism",null,null,29,29,29,"40.2","40.2","40.2","101.11",0,"323.31",8084300000,504,"0.822855",1,"-0.268563","-2.27841","sp|P56192|SYMC_HUMAN;tr|H0YIP0|H0YIP0_HUMAN;tr|H0YHV5|H0YHV5_HUMAN;tr|H0YI94|H0YI94_HUMAN;tr|H0YHL6|H0YHL6_HUMAN;tr|H0YI27|H0YI27_HUMAN;tr|F5H2V6|F5H2V6_HUMAN;tr|H0YIC2|H0YIC2_HUMAN","sp|P56192|SYMC_HUMAN",1778,"P56192","SYMC_HUMAN","Methionine--tRNA ligase, cytoplasmic",null,"MARS"]
["17.0007","18.929","16.4061","20.0613",{"$nulls":3},"transport","ATP binding;ATPase activity;transporter activity","ATP-binding cassette (ABC) transporter complex;membrane;mitochondrial envelope",{"$nulls":3},26,26,26,"36.9","36.9","36.9","71.289",0,"92.526",2209900000,213,"0.0417254",1,"-0.268822","-0.130096","sp|Q9UG63|ABCF2_HUMAN;tr|C9JHK9|C9JHK9_HUMAN;tr|C9JZV3|C9JZV3_HUMAN","sp|Q9UG63|ABCF2_HUMAN;tr|C9JHK9|C9JHK9_HUMAN;tr|C9JZV3|C9JZV3_HUMAN",4701,"Q9UG63","ABCF2_HUMAN","ATP-binding cassette sub-family F member 2",null,"ABCF2"]
["20.5363","21.5023","21.61","20.969",{"$nulls":3},"succinate metabolic process;succinyl-CoA metabolic process;succinyl-CoA pathway;tricarboxylic acid cycle","ATP binding;metal ion binding;succinate-CoA ligase (ADP-forming) activity","extracellular exosome;mitochondrial matrix;mitochondrion;myelin sheath","Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways;Propanoate metabolism",null,null,12,12,12,"28.9","28.9","28.9","50.317",0,"49.167",473880000,34,"0.163077",1,"-0.27022","-0.466155","sp|Q9P2R7|SUCB1_HUMAN;tr|Q5T9Q5|Q5T9Q5_HUMAN;tr|Q5T9Q8|Q5T9Q8_HUMAN","sp|Q9P2R7|SUCB1_HUMAN;tr|Q5T9Q5|Q5T9Q5_HUMAN",4649,"Q9P2R7","SUCB1_HUMAN","Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03220}",null,"SUCLA2"]
["13.2991",1,"13.8401",1,{"$nulls":3},"cellular response to DNA damage stimulus;double-strand break repair via nonhomologous end joining;intracellular protein transport;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination;spermatogenesis","guanyl-nucleotide exchange factor activity;SUMO binding;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity;zinc ion binding","centriole;cytoplasm;membrane;mitochondrial inner membrane;nucleoplasm;nucleus","Ubiquitin mediated proteolysis",null,null,8,8,8,"2.7","2.7","2.7","527.22",0,"23.011",128060000,22,"0.00944417",1,"-0.270513","-0.0304285","sp|O95714|HERC2_HUMAN;tr|A0A0J9YVP0|A0A0J9YVP0_HUMAN;sp|Q9BVR0|HRC23_HUMAN;tr|H3BUQ1|H3BUQ1_HUMAN","sp|O95714|HERC2_HUMAN;tr|A0A0J9YVP0|A0A0J9YVP0_HUMAN",755,"O95714","HERC2_HUMAN","E3 ubiquitin-protein ligase HERC2",null,"HERC2"]
["22.3681","22.1161","22.5824","22.4449",{"$nulls":3},"activation of MAPK activity;anaphase-promoting complex-dependent catabolic process;animal organ regeneration;apoptotic process;cell aging;cell division;cell migration;cell proliferation;cellular response to hydrogen peroxide;centrosome cycle;chromosome condensation;ciliary basal body-plasma membrane docking;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;DNA repair;DNA replication;epithelial cell differentiation;G2/M transition of mitotic cell cycle;Golgi disassembly;microtubule cytoskeleton organization;mitotic G2 DNA damage checkpoint;mitotic nuclear envelope disassembly;negative regulation of apoptotic process;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of cardiac muscle cell proliferation;positive regulation of DNA replication;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of gene expression;positive regulation of mitochondrial ATP synthesis coupled electron transport;positive regulation of protein import into nucleus, translocation;positive regulation of protein localization to nucleus;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;pronuclear fusion;proteasome-mediated ubiquitin-dependent protein catabolic process;protein complex assembly;protein deubiquitination;protein localization to kinetochore;protein phosphorylation;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of embryonic development;regulation of G2/M transition of mitotic cell cycle;regulation of gene expression;regulation of meiotic cell cycle;regulation of Schwann cell differentiation;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;response to activity;response to amine;response to axon injury;response to cadmium ion;response to copper ion;response to drug;response to ethanol;response to organic cyclic compound;response to toxic substance;transcription initiation from RNA polymerase II promoter;ventricular cardiac muscle cell development","ATP binding;chromatin binding;cyclin binding;cyclin-dependent protein kinase activity;cyclin-dependent protein serine/threonine kinase activity;histone kinase activity;Hsp70 protein binding;protein kinase activity;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity;virus receptor activity","centrosome;cyclin B1-CDK1 complex;cyclin-dependent protein kinase holoenzyme complex;cytosol;endoplasmic reticulum membrane;extracellular exosome;membrane;midbody;mitochondrial matrix;mitochondrion;mitotic spindle;nuclear chromosome, telomeric region;nucleoplasm;nucleus;spindle microtubule","Cell cycle;Cellular senescence;Gap junction;Human immunodeficiency virus 1 infection;Oocyte meiosis;p53 signaling pathway;Progesterone-mediated oocyte maturation;Viral carcinogenesis",null,null,16,15,14,"60.9","58.2","54.5","34.095",0,"85.241",1316500000,143,"0.701051",1,"-0.271557","-1.8919","sp|P06493|CDK1_HUMAN;tr|A0A024QZP7|A0A024QZP7_HUMAN;tr|A0A087WZZ9|A0A087WZZ9_HUMAN;tr|E5RIU6|E5RIU6_HUMAN;tr|K7ELV5|K7ELV5_HUMAN;tr|K7EJ83|K7EJ83_HUMAN;tr|H0YAZ9|H0YAZ9_HUMAN;tr|E7EUK8|E7EUK8_HUMAN;tr|E5RGN0|E5RGN0_HUMAN;sp|Q96Q40|CDK15_HUMAN;tr|A0A087WZU2|A0A087WZU2_HUMAN;sp|O94921|CDK14_HUMAN;tr|F5H6Z0|F5H6Z0_HUMAN;sp|Q07002|CDK18_HUMAN;sp|Q00536|CDK16_HUMAN;sp|Q00537|CDK17_HUMAN","sp|P06493|CDK1_HUMAN;tr|A0A024QZP7|A0A024QZP7_HUMAN;tr|A0A087WZZ9|A0A087WZZ9_HUMAN;tr|E5RIU6|E5RIU6_HUMAN",874,"P06493","CDK1_HUMAN","Cyclin-dependent kinase 1","DK1","CDK1"]
["21.2549","21.6193","21.4799","21.9417",{"$nulls":3},"post-translational protein modification","metal ion binding","endoplasmic reticulum;endoplasmic reticulum lumen",{"$nulls":3},10,10,10,"34.2","34.2","34.2","33.843",0,"26.091",397350000,30,"0.346452",1,"-0.273664","-0.93049","sp|Q8NBJ7|SUMF2_HUMAN;tr|J3KQJ1|J3KQJ1_HUMAN;tr|C9JL30|C9JL30_HUMAN;tr|A8MXB9|A8MXB9_HUMAN;tr|C9J660|C9J660_HUMAN;tr|E9PBT8|E9PBT8_HUMAN;tr|H7C3B2|H7C3B2_HUMAN;tr|F8WA42|F8WA42_HUMAN;tr|J3QT17|J3QT17_HUMAN;tr|E9PG02|E9PG02_HUMAN;tr|F8WEX5|F8WEX5_HUMAN;tr|F8WEV7|F8WEV7_HUMAN;tr|F8WES7|F8WES7_HUMAN","sp|Q8NBJ7|SUMF2_HUMAN;tr|J3KQJ1|J3KQJ1_HUMAN;tr|C9JL30|C9JL30_HUMAN;tr|A8MXB9|A8MXB9_HUMAN;tr|C9J660|C9J660_HUMAN;tr|E9PBT8|E9PBT8_HUMAN;tr|H7C3B2|H7C3B2_HUMAN;tr|F8WA42|F8WA42_HUMAN;tr|J3QT17|J3QT17_HUMAN;tr|E9PG02|E9PG02_HUMAN",3285,"Q8NBJ7","SUMF2_HUMAN","Sulfatase-modifying factor 2",null,"SUMF2"]
["20.5103","19.6401","20.0659","20.6344",{"$nulls":3},"dATP catabolic process;defense response to virus;deoxyribonucleotide catabolic process;dGTP catabolic process;immune response;protein homotetramerization;regulation of innate immune response;type I interferon signaling pathway","dGTP binding;dGTPase activity;identical protein binding;nucleic acid binding;ribonuclease activity;RNA binding;triphosphoric monoester hydrolase activity;zinc ion binding","intracellular;nucleoplasm;nucleus;plasma membrane","Human immunodeficiency virus 1 infection",null,null,14,14,14,"27.3","27.3","27.3","72.2",0,"42.626",520860000,51,"0.187357",1,"-0.274962","-0.529092","sp|Q9Y3Z3|SAMH1_HUMAN","sp|Q9Y3Z3|SAMH1_HUMAN",5000,"Q9Y3Z3","SAMH1_HUMAN","Deoxynucleoside triphosphate triphosphohydrolase SAMHD1","NTPase","SAMHD1"]
["21.9536","20.4639","21.8845","21.0834",{"$nulls":3},"arginine biosynthetic process via ornithine;urea cycle","argininosuccinate lyase activity;identical protein binding","cytoplasm;cytosol;extracellular exosome","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;Metabolic pathways",null,null,12,12,12,"27.2","27.2","27.2","51.657",0,"62.342",559880000,49,"0.110277",1,"-0.275205","-0.325421","sp|P04424|ARLY_HUMAN;tr|F8W943|F8W943_HUMAN;tr|H7C0S8|H7C0S8_HUMAN","sp|P04424|ARLY_HUMAN;tr|F8W943|F8W943_HUMAN",842,"P04424","ARLY_HUMAN","Argininosuccinate lyase","SAL","ASL"]
["22.0218","22.216","21.9993","22.789",{"$nulls":3},"cellular amino acid biosynthetic process;cellular response to oxidative stress;L-proline biosynthetic process;proline biosynthetic process","pyrroline-5-carboxylate reductase activity","mitochondrial matrix;mitochondrion","Arginine and proline metabolism;Biosynthesis of amino acids;Metabolic pathways",null,null,14,13,13,"49.4","45.3","45.3","33.637",0,"79.29",750440000,64,"0.245461",1,"-0.275224","-0.676931","sp|Q96C36|P5CR2_HUMAN;tr|A0A087WTV6|A0A087WTV6_HUMAN;tr|J3KR12|J3KR12_HUMAN;tr|A0A087WZR9|A0A087WZR9_HUMAN;tr|A0A087WX69|A0A087WX69_HUMAN;tr|A0A087WZF0|A0A087WZF0_HUMAN","sp|Q96C36|P5CR2_HUMAN;tr|A0A087WTV6|A0A087WTV6_HUMAN;tr|J3KR12|J3KR12_HUMAN;tr|A0A087WZR9|A0A087WZR9_HUMAN",3627,"Q96C36","P5CR2_HUMAN","Pyrroline-5-carboxylate reductase 2","5C reductase 2;5CR 2","PYCR2"]
["22.8939","23.4038","23.4918","23.3635",{"$nulls":3},"3'-phosphoadenosine 5'-phosphosulfate metabolic process;positive regulation of transcription from RNA polymerase II promoter","hydrolase activity","cytosol;extracellular exosome;nucleolus;nucleus",{"$nulls":3},7,7,7,"42.9","42.9","42.9","22.345",0,"86.376",787570000,41,"0.397836",1,"-0.27878","-1.0604","sp|Q96IU4|ABHEB_HUMAN;tr|B4DQI4|B4DQI4_HUMAN;tr|F8W9U3|F8W9U3_HUMAN","sp|Q96IU4|ABHEB_HUMAN;tr|B4DQI4|B4DQI4_HUMAN;tr|F8W9U3|F8W9U3_HUMAN",3735,"Q96IU4","ABHEB_HUMAN","Protein ABHD14B {ECO:0000305}",null,"ABHD14B"]
["20.756","20.4446","20.9488","20.8104",{"$nulls":3},"adult locomotory behavior;aging;axonogenesis;chemical synaptic transmission;cyclic nucleotide catabolic process;forebrain development;microtubule cytoskeleton organization;oligodendrocyte differentiation;regulation of mitochondrial membrane permeability;response to lipopolysaccharide;response to toxic substance;substantia nigra development","2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;cyclic nucleotide binding;RNA binding","cytoplasm;extracellular exosome;extracellular space;melanosome;membrane;microtubule;microvillus;mitochondrial inner membrane;mitochondrial outer membrane;myelin sheath abaxonal region;myelin sheath adaxonal region;perinuclear region of cytoplasm;plasma membrane;pseudopodium",{"$nulls":3},13,13,13,29,29,29,"47.578",0,"92.353",940160000,76,"0.614773",1,"-0.279368","-1.63948","sp|P09543|CN37_HUMAN;tr|K7ERC4|K7ERC4_HUMAN;tr|K7EN66|K7EN66_HUMAN;tr|C9K0L8|C9K0L8_HUMAN;tr|K7ERZ0|K7ERZ0_HUMAN","sp|P09543|CN37_HUMAN",949,"P09543","CN37_HUMAN","2',3'-cyclic-nucleotide 3'-phosphodiesterase","NP;NPase","CNP"]
["20.5665","19.8314","20.9511","20.0092",{"$nulls":4},"microtubule motor activity","kinesin complex",{"$nulls":3},18,18,1,"34.5","34.5","2.8","68.774",0,"64.608",515100000,36,"0.164816",1,"-0.281196","-0.470695","tr|G3V3H3|G3V3H3_HUMAN;tr|G3V5R9|G3V5R9_HUMAN;tr|G5E9S8|G5E9S8_HUMAN;tr|G3V2E7|G3V2E7_HUMAN;sp|Q07866|KLC1_HUMAN;tr|F8W6L3|F8W6L3_HUMAN;tr|H0YJU9|H0YJU9_HUMAN;tr|H0YJL0|H0YJL0_HUMAN;tr|H0YJT3|H0YJT3_HUMAN;tr|H0YG16|H0YG16_HUMAN;tr|G3V2P7|G3V2P7_HUMAN;tr|H0YGB8|H0YGB8_HUMAN","tr|G3V3H3|G3V3H3_HUMAN;tr|G3V5R9|G3V5R9_HUMAN;tr|G5E9S8|G5E9S8_HUMAN;tr|G3V2E7|G3V2E7_HUMAN;sp|Q07866|KLC1_HUMAN;tr|F8W6L3|F8W6L3_HUMAN",5238,"G3V3H3","G3V3H3_HUMAN",null,null,"KLC1"]
["20.7875","19.2456","21.3751","19.2221",{"$nulls":3},"lipid particle organization",null,"cell surface;endoplasmic reticulum membrane;Golgi apparatus;integral component of membrane;plasma membrane",{"$nulls":3},18,18,18,"23.9","23.9","23.9","98.555",0,"36.999",718720000,37,"0.0700457",1,"-0.282063","-0.213026","sp|Q9P2B2|FPRP_HUMAN","sp|Q9P2B2|FPRP_HUMAN",4637,"Q9P2B2","FPRP_HUMAN","Prostaglandin F2 receptor negative regulator",null,"PTGFRN"]
["22.0757","22.5604","22.2877","22.9162",{"$nulls":3},"protein targeting to ER;proteolysis;signal peptide processing","peptidase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;organelle membrane;signal peptidase complex","Protein export",null,null,3,3,3,"15.6","15.6","15.6","20.313",0,"8.0601",383720000,24,"0.260731",1,"-0.283875","-0.715376","sp|P61009|SPCS3_HUMAN","sp|P61009|SPCS3_HUMAN",1821,"P61009","SPCS3_HUMAN","Signal peptidase complex subunit 3",null,"SPCS3"]
["20.0415","20.8256","20.8084","20.6271",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;translation","RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial large ribosomal subunit;mitochondrial ribosome;mitochondrion","Ribosome",null,null,6,6,6,24,24,24,"30.243",0,"13.881",190630000,19,"0.257177",1,"-0.284242","-0.706438","sp|Q9BYD2|RM09_HUMAN;tr|Q5SZR1|Q5SZR1_HUMAN","sp|Q9BYD2|RM09_HUMAN;tr|Q5SZR1|Q5SZR1_HUMAN",4060,"Q9BYD2","RM09_HUMAN","39S ribosomal protein L9, mitochondrial","9mt;RP-L9","MRPL9"]
["20.7024","20.6773","21.1249","20.8263",{"$nulls":3},"negative regulation of axonogenesis;negative regulation of protein targeting to membrane;positive regulation of axon extension;protein transport;Rab protein signal transduction;regulation of small GTPase mediated signal transduction;response to calcium ion;signal transduction","GDP-dissociation inhibitor activity;GTPase activator activity;Rab GDP-dissociation inhibitor activity;Rab GTPase binding","axon;cytoplasm;cytosol;Golgi apparatus;midbody;myelin sheath;neuronal cell body;protein complex",{"$nulls":3},20,10,10,"54.6",30,30,"50.582",0,"49.295",403530000,43,"0.70592",1,"-0.285715","-1.90663","sp|P31150|GDIA_HUMAN;tr|G5E9U5|G5E9U5_HUMAN","sp|P31150|GDIA_HUMAN",1325,"P31150","GDIA_HUMAN","Rab GDP dissociation inhibitor alpha","ab GDI alpha","GDI1"]
["16.2534","17.0849","16.8544","17.0589",{"$nulls":4},"K63-linked polyubiquitin modification-dependent protein binding","cytosol",{"$nulls":3},3,3,1,"11.2","11.2","2.9","47.256",0,"9.1181",30492000,7,"0.24328",1,"-0.287483","-0.67143","tr|A0A087X0G7|A0A087X0G7_HUMAN;tr|A0A087WUW6|A0A087WUW6_HUMAN;tr|A0A087X1B1|A0A087X1B1_HUMAN;sp|Q9Y6K9|NEMO_HUMAN;tr|C9JH59|C9JH59_HUMAN;tr|C9JN51|C9JN51_HUMAN;tr|A0A087WV30|A0A087WV30_HUMAN;tr|C9JCG6|C9JCG6_HUMAN","tr|A0A087X0G7|A0A087X0G7_HUMAN;tr|A0A087WUW6|A0A087WUW6_HUMAN;tr|A0A087X1B1|A0A087X1B1_HUMAN;sp|Q9Y6K9|NEMO_HUMAN;tr|C9JH59|C9JH59_HUMAN;tr|C9JN51|C9JN51_HUMAN",5103,"A0A087X0G7","A0A087X0G7_HUMAN",null,null,"IKBKG"]
["24.1185","23.7696","24.2272","24.2388",{"$nulls":3},"hair cycle;histone mRNA metabolic process;mRNA splicing, via spliceosome;nuclear import;spliceosomal complex assembly;spliceosomal snRNP assembly;termination of RNA polymerase II transcription","RNA binding","catalytic step 2 spliceosome;cytosol;extracellular exosome;methylosome;nucleoplasm;nucleus;pICln-Sm protein complex;precatalytic spliceosome;small nuclear ribonucleoprotein complex;SMN-Sm protein complex;spliceosomal complex;U1 snRNP;U12-type spliceosomal complex;U2 snRNP;U4 snRNP;U4/U6 x U5 tri-snRNP complex;U5 snRNP;U7 snRNP","Spliceosome",null,null,2,2,2,25,25,25,"10.803",0,"15.746",979930000,29,"0.620485",1,"-0.28896","-1.65572","sp|P62304|RUXE_HUMAN;tr|A6NHK2|A6NHK2_HUMAN","sp|P62304|RUXE_HUMAN;tr|A6NHK2|A6NHK2_HUMAN",1887,"P62304","RUXE_HUMAN","Small nuclear ribonucleoprotein E","nRNP-E","SNRPE"]
["17.9356","18.9228","18.0189","19.4208",{"$nulls":3},"regulation of transcription, DNA-templated","histone-lysine N-methyltransferase activity","chromosome",{"$nulls":3},2,2,2,"6.9","6.9","6.9","40.127","0.0006683","4.114",54482000,6,"0.115267",1,"-0.290628","-0.339008","tr|D6RJA0|D6RJA0_HUMAN;sp|Q8WTS6|SETD7_HUMAN","tr|D6RJA0|D6RJA0_HUMAN;sp|Q8WTS6|SETD7_HUMAN",3410,"D6RJA0","D6RJA0_HUMAN","Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00910}",null,"SETD7"]
["20.445","19.3494","20.3901","19.9872",{"$nulls":3},"attachment of GPI anchor to protein","GPI-anchor transamidase activity","endoplasmic reticulum membrane;GPI-anchor transamidase complex;membrane","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis;Metabolic pathways",null,null,9,9,9,"28.1","28.1","28.1","61.655",0,"25.044",280620000,25,"0.175838",1,"-0.291438","-0.499344","sp|Q96S52|PIGS_HUMAN;tr|K7EN97|K7EN97_HUMAN","sp|Q96S52|PIGS_HUMAN",3812,"Q96S52","PIGS_HUMAN","GPI transamidase component PIG-S",null,"PIGS"]
["23.7071","23.201","23.7629","23.7304",{"$nulls":3},"cellular respiration;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;negative regulation of cell growth;negative regulation of intrinsic apoptotic signaling pathway;reactive oxygen species metabolic process;substantia nigra development","electron transfer activity;NADH dehydrogenase (ubiquinone) activity;NADH dehydrogenase activity","mitochondrial matrix;mitochondrial membrane;mitochondrial respiratory chain complex I;mitochondrion;myelin sheath;nuclear body","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,13,13,13,"46.6","46.6","46.6","30.241",0,"140.67",1614400000,47,"0.43438",1,"-0.29261","-1.1539","sp|O75489|NDUS3_HUMAN;tr|E9PS48|E9PS48_HUMAN;tr|G3V194|G3V194_HUMAN;tr|E9PKL8|E9PKL8_HUMAN","sp|O75489|NDUS3_HUMAN",579,"O75489","NDUS3_HUMAN","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial",null,"NDUFS3"]
["18.5283","19.6164","19.6527","19.0818",{"$nulls":3},"acylglycerol metabolic process;CDP-diacylglycerol biosynthetic process;hematopoietic progenitor cell differentiation;phosphatidic acid biosynthetic process;phospholipid biosynthetic process","1-acylglycerol-3-phosphate O-acyltransferase activity","endoplasmic reticulum membrane;integral component of membrane;mitochondrial outer membrane;mitochondrion;nuclear envelope","Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phospholipase D signaling pathway",null,null,4,4,4,17,17,17,"42.072",0,"50.518",426240000,36,"0.168384",1,"-0.294918","-0.47999","sp|Q9NUQ2|PLCE_HUMAN;tr|H0YC22|H0YC22_HUMAN","sp|Q9NUQ2|PLCE_HUMAN",4467,"Q9NUQ2","PLCE_HUMAN","1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon",null,"AGPAT5"]
["22.0492","21.0945","22.1592","21.5759",{"$nulls":3},"associative learning;cellular response to brain-derived neurotrophic factor stimulus;cellular response to selenite ion;embryonic cranial skeleton morphogenesis;exploration behavior;mRNA 3'-end processing;mRNA export from nucleus;mRNA splicing, via spliceosome;negative regulation of excitatory postsynaptic potential;negative regulation of selenocysteine incorporation;negative regulation of selenocysteine insertion sequence binding;negative regulation of translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;nuclear-transcribed mRNA poly(A) tail shortening;positive regulation of translation;response to organic cyclic compound;RNA export from nucleus;RNA secondary structure unwinding;RNA splicing;rRNA processing;termination of RNA polymerase II transcription","ATP binding;ATP-dependent RNA helicase activity;mRNA binding;poly(A) binding;ribonucleoprotein complex binding;RNA binding;RNA stem-loop binding;selenocysteine insertion sequence binding","catalytic step 2 spliceosome;cytoplasm;cytosol;dendrite;exon-exon junction complex;membrane;neuronal cell body;nuclear speck;nucleolus;nucleoplasm","mRNA surveillance pathway;RNA transport;Spliceosome",null,null,14,11,11,"39.9","34.1","34.1","46.871",0,"60.833",823360000,71,"0.187166",1,"-0.2957","-0.528601","sp|P38919|IF4A3_HUMAN;tr|I3L3H2|I3L3H2_HUMAN","sp|P38919|IF4A3_HUMAN",1428,"P38919","IF4A3_HUMAN","Eukaryotic initiation factor 4A-III","IF4A-III;IF-4A-III","EIF4A3"]
["17.6693","17.8579","18.4621","17.6572",{"$nulls":3},"7-methylguanosine mRNA capping;aging;apoptotic process;bone mineralization;cell proliferation;central nervous system myelin formation;chromosome segregation;embryonic cleavage;embryonic organ development;erythrocyte maturation;extracellular matrix organization;global genome nucleotide-excision repair;hair cell differentiation;hair follicle maturation;hematopoietic stem cell differentiation;in utero embryonic development;multicellular organism growth;nucleotide-excision repair;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;positive regulation of DNA binding;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;post-embryonic development;protein phosphorylation;regulation of mitotic cell cycle phase transition;response to hypoxia;response to oxidative stress;spinal cord development;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription-coupled nucleotide-excision repair;UV protection;viral process","4 iron, 4 sulfur cluster binding;5'-3' DNA helicase activity;ATP binding;ATP-dependent DNA helicase activity;DNA binding;DNA-dependent ATPase activity;metal ion binding;protein C-terminus binding;protein N-terminus binding","core TFIIH complex;cytoplasm;cytosol;holo TFIIH complex;MMXD complex;nucleoplasm;nucleus;spindle;transcription factor TFIID complex","Basal transcription factors;Nucleotide excision repair",null,null,16,16,16,28,28,28,"86.908",0,"84.273",819860000,76,"0.261068",1,"-0.296026","-0.716225","sp|P18074|ERCC2_HUMAN;tr|E7EVE9|E7EVE9_HUMAN;tr|A8MX75|A8MX75_HUMAN;tr|K7EIT8|K7EIT8_HUMAN;tr|B4E0F6|B4E0F6_HUMAN;tr|K7ENL1|K7ENL1_HUMAN;tr|K7EKF3|K7EKF3_HUMAN","sp|P18074|ERCC2_HUMAN;tr|E7EVE9|E7EVE9_HUMAN;tr|A8MX75|A8MX75_HUMAN",1112,"P18074","ERCC2_HUMAN","General transcription and DNA repair factor IIH helicase subunit XPD","FIIH subunit XPD","ERCC2"]
["17.6269","17.7586","18.2885","17.6898",{"$nulls":3},"antigen processing and presentation;immune response;intracellular protein transport","MHC class II protein binding","integral component of membrane;intracellular",{"$nulls":3},1,1,1,"11.5","11.5","11.5","13.917","0.0006737","4.2131",28729000,3,"0.360944",1,"-0.296403","-0.966985","tr|E7EQJ3|E7EQJ3_HUMAN;tr|H0YBZ8|H0YBZ8_HUMAN;tr|E7ESL3|E7ESL3_HUMAN;sp|P04233|HG2A_HUMAN;tr|H0YBZ2|H0YBZ2_HUMAN","tr|E7EQJ3|E7EQJ3_HUMAN;tr|H0YBZ8|H0YBZ8_HUMAN;tr|E7ESL3|E7ESL3_HUMAN;sp|P04233|HG2A_HUMAN;tr|H0YBZ2|H0YBZ2_HUMAN",839,"E7EQJ3","E7EQJ3_HUMAN",null,null,"CD74"]
["22.4578","21.2245","22.5923","21.6862",{"$nulls":3},"biosynthetic process;cellular amino acid metabolic process;L-threonine catabolic process to glycine","glycine C-acetyltransferase activity;pyridoxal phosphate binding","mitochondrial inner membrane;mitochondrion;nuclear speck;nucleoplasm","Glycine, serine and threonine metabolism;Metabolic pathways",null,null,4,4,3,"16.9","16.9","14.3","45.285",0,"85.78",775600000,33,"0.134043",1,"-0.298081","-0.389544","sp|O75600|KBL_HUMAN;tr|C9IZC9|C9IZC9_HUMAN;tr|H7BZ75|H7BZ75_HUMAN","sp|O75600|KBL_HUMAN",591,"O75600","KBL_HUMAN","2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial","KB ligase","GCAT"]
["19.3523","19.3279","20.0319","19.2464",{"$nulls":3},"branching involved in ureteric bud morphogenesis;cell aging;cell cycle arrest;cell junction assembly;cell proliferation;cell-matrix adhesion;establishment or maintenance of epithelial cell apical/basal polarity;fibroblast migration;integrin-mediated signaling pathway;MAPK cascade;multicellular organism development;myelin assembly;myelination in peripheral nervous system;negative regulation of cardiac muscle cell apoptotic process;negative regulation of neural precursor cell proliferation;negative regulation of neuron apoptotic process;negative regulation of protein kinase activity;negative regulation of smooth muscle cell migration;negative regulation of smooth muscle cell proliferation;nerve development;neuron projection morphogenesis;outflow tract morphogenesis;peptidyl-serine phosphorylation;platelet aggregation;positive regulation of axon extension;positive regulation of BMP signaling pathway;positive regulation of canonical Wnt signaling pathway;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of cell-matrix adhesion;positive regulation of dendrite morphogenesis;positive regulation of MAP kinase activity;positive regulation of myoblast differentiation;positive regulation of NIK/NF-kappaB signaling;positive regulation of osteoblast differentiation;positive regulation of phosphorylation;positive regulation of protein kinase B signaling;positive regulation of transcription, DNA-templated;protein heterooligomerization;protein kinase B signaling;protein phosphorylation;regulation of actin cytoskeleton organization;substrate adhesion-dependent cell spreading;supramolecular fiber organization;tumor necrosis factor-mediated signaling pathway","ATP binding;integrin binding;protein kinase binding;protein serine/threonine kinase activity;SH3 domain binding;signal transducer activity","cell junction;cell-cell junction;costamere;cytoplasm;cytosol;dendritic shaft;focal adhesion;lamellipodium;membrane;neuronal cell body;nucleoplasm;plasma membrane;protein complex;sarcomere;stress fiber;terminal bouton","Axon guidance;Bacterial invasion of epithelial cells;Endometrial cancer;Focal adhesion;PPAR signaling pathway",null,null,9,9,9,"22.1","22.1","22.1","51.419",0,"13.253",168860000,17,"0.278944",1,"-0.299047","-0.761116","sp|Q13418|ILK_HUMAN;tr|A0A0A0MTH3|A0A0A0MTH3_HUMAN;tr|A0A087WWY6|A0A087WWY6_HUMAN","sp|Q13418|ILK_HUMAN;tr|A0A0A0MTH3|A0A0A0MTH3_HUMAN",2248,"Q13418","ILK_HUMAN","Integrin-linked protein kinase",null,"ILK"]
["23.5495","23.8664","23.9041","24.11",{"$nulls":3},"cellular protein modification process","ATP binding;catalytic activity",{"$nulls":4},24,24,24,"45.5","45.5","45.5","74.403",0,"214.15",4011600000,157,"0.594707",1,"-0.299109","-1.58293","sp|Q14166|TTL12_HUMAN;tr|V9GY16|V9GY16_HUMAN","sp|Q14166|TTL12_HUMAN",2341,"Q14166","TTL12_HUMAN","Tubulin--tyrosine ligase-like protein 12",null,"TTLL12"]
["24.3063","22.9932","24.5263","23.3753",{"$nulls":3},"IRE1-mediated unfolded protein response;posttranslational protein targeting to membrane, translocation;protein import into nucleus, translocation;retrograde protein transport, ER to cytosol;SRP-dependent cotranslational protein targeting to membrane, translocation;ubiquitin-dependent ERAD pathway","ARF guanyl-nucleotide exchange factor activity;epidermal growth factor binding;RNA binding","cytosol;endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum Sec complex;integral component of membrane;membrane;Sec61 translocon complex","Phagosome;Protein export;Protein processing in endoplasmic reticulum;Vibrio cholerae infection",null,null,3,3,3,"37.5","37.5","37.5","9.9743",0,"36.736",2015100000,64,"0.117409",1,"-0.30106","-0.344817","sp|P60468|SC61B_HUMAN;tr|S4R3B5|S4R3B5_HUMAN","sp|P60468|SC61B_HUMAN",1807,"P60468","SC61B_HUMAN","Protein transport protein Sec61 subunit beta",null,"SEC61B"]
["15.3354","15.9531","16.3263","15.5734",{"$nulls":3},"cellular response to amino acid stimulus;endocytosis;negative regulation of cell growth;negative regulation of cell proliferation;negative regulation of GTPase activity;negative regulation of TOR signaling;positive regulation of autophagy;protein localization to lysosome;regulation of catalytic activity","GDP-dissociation inhibitor activity;identical protein binding;Ras GTPase binding","clathrin-coated pit;clathrin-coated vesicle;cytoplasm;extracellular exosome;nucleus",{"$nulls":3},7,7,7,"9.8","9.8","9.8","107.49",0,"18.374",109590000,17,"0.225994",1,"-0.30564","-0.627726","sp|Q9P0V3|SH3B4_HUMAN;tr|C9JF25|C9JF25_HUMAN;tr|C9JED2|C9JED2_HUMAN","sp|Q9P0V3|SH3B4_HUMAN",4622,"Q9P0V3","SH3B4_HUMAN","SH3 domain-binding protein 4",null,"SH3BP4"]
["21.346","20.2246","21.4467","20.7375",{"$nulls":3},"protein oligomerization;regulation of RNA splicing;regulation of voltage-gated calcium channel activity","cadherin binding;RNA binding;S100 protein binding;structural molecule activity conferring elasticity","actin cytoskeleton;cell-cell contact zone;costamere;cytoplasm;cytosol;extracellular exosome;focal adhesion;lysosomal membrane;membrane;nucleus;plasma membrane;sarcolemma;T-tubule;vesicle",{"$nulls":3},141,141,141,"50.8","50.8","50.8","629.09",0,"323.31",8495400000,667,"0.161653",1,"-0.306791","-0.462435","sp|Q09666|AHNK_HUMAN;tr|E9PQE3|E9PQE3_HUMAN;tr|E9PJZ0|E9PJZ0_HUMAN;tr|E9PKR9|E9PKR9_HUMAN;tr|E9PJC6|E9PJC6_HUMAN;tr|E9PLK4|E9PLK4_HUMAN","sp|Q09666|AHNK_HUMAN",2143,"Q09666","AHNK_HUMAN","Neuroblast differentiation-associated protein AHNAK",null,"AHNAK"]
["23.2778","23.2112","23.827","23.2767",{"$nulls":3},"Arp2/3 complex-mediated actin nucleation;asymmetric cell division;cellular response to interferon-gamma;cilium assembly;ephrin receptor signaling pathway;establishment or maintenance of cell polarity;Fc-gamma receptor signaling pathway involved in phagocytosis;meiotic chromosome movement towards spindle pole;meiotic cytokinesis;membrane organization;movement of cell or subcellular component;spindle localization","actin binding;ATP binding;structural constituent of cytoskeleton","actin cytoskeleton;Arp2/3 protein complex;brush border;cell-cell junction;cytosol;extracellular exosome;focal adhesion;lamellipodium;membrane","Tight junction;Yersinia infection",null,null,19,19,15,"55.5","55.5",49,"47.371",0,"104.96",2382000000,136,"0.41684",1,"-0.307329","-1.10888","sp|P61158|ARP3_HUMAN;tr|B4DXW1|B4DXW1_HUMAN;tr|F8WDR7|F8WDR7_HUMAN","sp|P61158|ARP3_HUMAN;tr|B4DXW1|B4DXW1_HUMAN",1832,"P61158","ARP3_HUMAN","Actin-related protein 3",null,"ACTR3"]
["19.5663","21.1382","20.8998","20.4253",{"$nulls":4},"enzyme activator activity;heme binding;metal ion binding","integral component of membrane;mitochondrial inner membrane;mitochondrial outer membrane",{"$nulls":3},2,2,2,18,18,18,"16.694",0,"18.892",81013000,9,"0.129717",1,"-0.310309","-0.377977","tr|J3KNF8|J3KNF8_HUMAN;tr|D6RFH4|D6RFH4_HUMAN;tr|H3BUX2|H3BUX2_HUMAN;sp|O43169|CYB5B_HUMAN","tr|J3KNF8|J3KNF8_HUMAN;tr|D6RFH4|D6RFH4_HUMAN;tr|H3BUX2|H3BUX2_HUMAN;sp|O43169|CYB5B_HUMAN",5274,"J3KNF8","J3KNF8_HUMAN"]
["14.9263","13.0291","14.3373","14.2408",{"$nulls":3},"cell cycle phase transition;cell division;DNA replication;DNA replication initiation;double-strand break repair via break-induced replication;G1/S transition of mitotic cell cycle;negative regulation of G0 to G1 transition;peptidyl-serine phosphorylation;phagocytosis;positive regulation of cell proliferation;positive regulation of G2/M transition of mitotic cell cycle;positive regulation of nuclear cell cycle DNA replication;regulation of cell shape","ATP binding;kinase activity;metal ion binding;protein kinase activity;protein serine/threonine kinase activity","cytoplasm;intercellular bridge;mitotic spindle;nucleoplasm;nucleus","Cell cycle",null,null,1,1,1,"1.7","1.7","1.7","63.887","0.00024091","5.5737",50464000,9,"0.111138",1,"-0.311318","-0.32777","sp|O00311|CDC7_HUMAN","sp|O00311|CDC7_HUMAN",214,"O00311","CDC7_HUMAN","Cell division cycle 7-related protein kinase","DC7-related kinase;sCdc7;uCdc7","CDC7"]
["18.4423","16.5442","19.0623","16.5508",{"$nulls":3},"glycosphingolipid metabolic process;neutrophil degranulation;post-translational protein modification","arylsulfatase activity;calcium ion binding;cerebroside-sulfatase activity;sulfuric ester hydrolase activity","azurophil granule lumen;endoplasmic reticulum lumen;extracellular exosome;extracellular region;lysosomal lumen;lysosome","Lysosome;Sphingolipid metabolism",null,null,3,3,3,"9.3","9.3","9.3","53.588",0,"8.0333",32704000,4,"0.0651809",1,"-0.313283","-0.199034","sp|P15289|ARSA_HUMAN;tr|A0A0C4DFZ2|A0A0C4DFZ2_HUMAN","sp|P15289|ARSA_HUMAN;tr|A0A0C4DFZ2|A0A0C4DFZ2_HUMAN",1059,"P15289","ARSA_HUMAN","Arylsulfatase A","SA","ARSA"]
["20.4513","20.7502","20.5446","21.2871",{"$nulls":3},"detection of chemical stimulus involved in sensory perception of bitter taste;epidermal growth factor receptor signaling pathway;Fc receptor signaling pathway;immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor;neutrophil degranulation;receptor clustering;retina homeostasis","polymeric immunoglobulin receptor activity","azurophil granule membrane;extracellular exosome;extracellular space;integral component of plasma membrane;plasma membrane;receptor complex","Intestinal immune network for IgA production",null,null,20,20,20,"32.1","32.1","32.1","83.283",0,"82.923",863100000,105,"0.289441",1,"-0.315118","-0.787443","sp|P01833|PIGR_HUMAN","sp|P01833|PIGR_HUMAN",819,"P01833","PIGR_HUMAN","Polymeric immunoglobulin receptor","IgR;oly-Ig receptor","PIGR"]
["24.9466","24.4271","25.1474","24.8584",{"$nulls":3},"cell redox homeostasis;cellular response to oxidative stress;cellular response to reactive oxygen species;hydrogen peroxide catabolic process;maternal placenta development;mitochondrion organization;myeloid cell differentiation;negative regulation of apoptotic process;negative regulation of kinase activity;peptidyl-cysteine oxidation;positive regulation of cell proliferation;positive regulation of NF-kappaB transcription factor activity;regulation of mitochondrial membrane potential;response to hydrogen peroxide;response to lipopolysaccharide;response to oxidative stress","alkyl hydroperoxide reductase activity;cysteine-type endopeptidase inhibitor activity involved in apoptotic process;identical protein binding;kinase binding;protein C-terminus binding;protein kinase binding;thioredoxin peroxidase activity","cytoplasm;cytosol;early endosome;extracellular exosome;mitochondrial matrix;mitochondrion;myelin sheath;protein complex",{"$nulls":3},8,8,8,"40.2","40.2","40.2","27.692",0,"127.63",3845100000,106,"0.398994",1,"-0.31606","-1.06334","sp|P30048|PRDX3_HUMAN","sp|P30048|PRDX3_HUMAN",1297,"P30048","PRDX3_HUMAN","Thioredoxin-dependent peroxide reductase, mitochondrial",null,"PRDX3"]
["28.1905","27.6597","28.3509","28.1334",{"$nulls":3},"actin cytoskeleton organization;actin filament depolymerization;actin filament fragmentation;cytoskeleton organization;establishment of cell polarity;interleukin-12-mediated signaling pathway;mitotic cytokinesis;negative regulation of apoptotic process;neural crest cell migration;neural fold formation;positive regulation by host of viral process;positive regulation of actin filament depolymerization;protein phosphorylation;regulation of cell morphogenesis;regulation of dendritic spine morphogenesis;response to amino acid;response to virus;Rho protein signal transduction","actin filament binding;receptor binding","cell-cell junction;cortical actin cytoskeleton;cytoplasm;cytosol;extracellular exosome;extracellular matrix;extracellular space;focal adhesion;lamellipodium;lamellipodium membrane;membrane;nuclear matrix;nucleus;ruffle membrane;vesicle","Axon guidance;Fc gamma R-mediated phagocytosis;Human immunodeficiency virus 1 infection;Pertussis;Regulation of actin cytoskeleton",null,null,13,13,9,"72.3","72.3","51.2","18.502",0,"287.64",24515000000,297,"0.415512",1,"-0.31707","-1.10548","sp|P23528|COF1_HUMAN;tr|G3V1A4|G3V1A4_HUMAN;tr|E9PK25|E9PK25_HUMAN;tr|E9PP50|E9PP50_HUMAN;tr|E9PQB7|E9PQB7_HUMAN;tr|E9PLJ3|E9PLJ3_HUMAN;tr|E9PS23|E9PS23_HUMAN","sp|P23528|COF1_HUMAN;tr|G3V1A4|G3V1A4_HUMAN;tr|E9PK25|E9PK25_HUMAN;tr|E9PP50|E9PP50_HUMAN;tr|E9PQB7|E9PQB7_HUMAN",1204,"P23528","COF1_HUMAN","Cofilin-1",null,"CFL1"]
["20.281","18.8361","20.3464","19.4083",{"$nulls":4},"receptor activity","integral component of membrane",{"$nulls":3},4,4,4,"26.1","26.1","26.1","22.209",0,"9.1033",81868000,2,"0.126749",1,"-0.318714","-0.370015","tr|H7C240|H7C240_HUMAN;sp|O75787|RENR_HUMAN;tr|H0Y750|H0Y750_HUMAN;tr|H7C3E1|H7C3E1_HUMAN","tr|H7C240|H7C240_HUMAN;sp|O75787|RENR_HUMAN;tr|H0Y750|H0Y750_HUMAN;tr|H7C3E1|H7C3E1_HUMAN",609,"H7C240","H7C240_HUMAN",null,null,"ATP6AP2"]
["19.7493","19.2116","20.093","19.5063",{"$nulls":3},"histone H3-K9 demethylation;regulation of transcription, DNA-templated;response to cisplatin;transcription, DNA-templated","antioxidant activity;chromatin DNA binding;dioxygenase activity;histone demethylase activity;histone demethylase activity (H3-K9 specific);metal ion binding;transcription regulatory region sequence-specific DNA binding","chromatin;nucleoplasm;nucleus","Thermogenesis",null,null,21,21,21,"21.1","21.1","21.1","191.58",0,"73.035",569260000,54,"0.295305",1,"-0.319201","-0.802145","sp|Q7LBC6|KDM3B_HUMAN;tr|H0Y9V5|H0Y9V5_HUMAN","sp|Q7LBC6|KDM3B_HUMAN",2978,"Q7LBC6","KDM3B_HUMAN","Lysine-specific demethylase 3B",null,"KDM3B"]
["18.2363",1,"18.8757",1,{"$nulls":3},"microtubule bundle formation;microtubule polymerization","tubulin binding","cytoplasm;extracellular exosome;microtubule",{"$nulls":3},1,1,1,8,8,8,"18.985","0.0037113","3.0473",8687800,2,"0.00797937",1,"-0.31972","-0.0257506","sp|Q9BW30|TPPP3_HUMAN","sp|Q9BW30|TPPP3_HUMAN",4022,"Q9BW30","TPPP3_HUMAN","Tubulin polymerization-promoting protein family member 3",null,"TPPP3"]
["21.6581","21.0562","22.1466","21.2101",{"$nulls":4},"RNA binding",{"$nulls":4},15,15,8,"31.4","31.4","21.1","63.674",0,"52.04",527160000,60,"0.206067",1,"-0.321198","-0.57705","tr|A0A087X0Q1|A0A087X0Q1_HUMAN;sp|Q7Z739|YTHD3_HUMAN;tr|A0A024R7W5|A0A024R7W5_HUMAN;tr|A0A087WY31|A0A087WY31_HUMAN;tr|A0A087X0C3|A0A087X0C3_HUMAN;tr|S4R373|S4R373_HUMAN","tr|A0A087X0Q1|A0A087X0Q1_HUMAN;sp|Q7Z739|YTHD3_HUMAN;tr|A0A024R7W5|A0A024R7W5_HUMAN;tr|A0A087WY31|A0A087WY31_HUMAN",3017,"A0A087X0Q1","A0A087X0Q1_HUMAN",null,null,"YTHDF3"]
["20.259","19.9223","20.527","20.3023",{"$nulls":3},"angiotensin-activated signaling pathway;epithelial fluid transport;mRNA polyadenylation;one-carbon metabolic process;positive regulation of sodium ion transport;protein export from nucleus;regulation of anion transport;regulation of cardiac conduction;regulation of ion transmembrane transporter activity;regulation of mRNA 3'-end processing;response to calcium ion;S-adenosylmethionine cycle","identical protein binding;RNA binding","apical plasma membrane;cytoplasm;cytosol;endoplasmic reticulum membrane;extracellular exosome","Cysteine and methionine metabolism;Metabolic pathways",null,null,6,6,6,"13.6","13.6","13.6","58.951",0,"28.769",279040000,22,"0.601022",1,"-0.323954","-1.60065","sp|O43865|SAHH2_HUMAN;tr|H0Y8B3|H0Y8B3_HUMAN;sp|Q96HN2|SAHH3_HUMAN","sp|O43865|SAHH2_HUMAN;tr|H0Y8B3|H0Y8B3_HUMAN;sp|Q96HN2|SAHH3_HUMAN",448,"O43865","SAHH2_HUMAN","S-adenosylhomocysteine hydrolase-like protein 1 {ECO:0000312|HGNC:HGNC:344}",null,"AHCYL1"]
[1,"15.9905",1,"16.6398",{"$nulls":3},"glycoside catabolic process;glycosphingolipid catabolic process;glycosphingolipid metabolic process;glycosylceramide catabolic process;negative regulation of nitric oxide biosynthetic process;negative regulation of nitric-oxide synthase activity;neutrophil degranulation;oligosaccharide metabolic process","alpha-galactosidase activity;catalytic activity;galactoside binding;hydrolase activity;protein homodimerization activity;raffinose alpha-galactosidase activity;receptor binding","azurophil granule lumen;cytoplasm;extracellular exosome;extracellular region;Golgi apparatus;lysosomal lumen;lysosome","Galactose metabolism;Glycerolipid metabolism;Glycosphingolipid biosynthesis - globo and isoglobo series;Lysosome;Metabolic pathways;Sphingolipid metabolism",null,null,1,1,1,"2.8","2.8","2.8","48.766","0.0066942","2.5123",14369000,0,"0.00930004",1,"-0.32462","-0.0299689","sp|P06280|AGAL_HUMAN","sp|P06280|AGAL_HUMAN",870,"P06280","AGAL_HUMAN","Alpha-galactosidase A",null,"GLA"]
["15.4707","17.9818","15.7549","18.3482",{"$nulls":3},"activation of cysteine-type endopeptidase activity involved in apoptotic process;activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;activin receptor signaling pathway;canonical Wnt signaling pathway;cell cycle arrest;cell-cell junction organization;cellular response to transforming growth factor beta stimulus;developmental growth;embryonic cranial skeleton morphogenesis;embryonic foregut morphogenesis;embryonic pattern specification;endoderm development;evasion or tolerance of host defenses by virus;extrinsic apoptotic signaling pathway;heart looping;immune response;immune system development;in utero embryonic development;lens fiber cell differentiation;liver development;mesoderm formation;negative regulation of apoptotic process;negative regulation of cardiac muscle hypertrophy in response to stress;negative regulation of cell growth;negative regulation of cytosolic calcium ion concentration;negative regulation of fat cell differentiation;negative regulation of inflammatory response;negative regulation of lung blood pressure;negative regulation of mitotic cell cycle;negative regulation of osteoblast differentiation;negative regulation of osteoblast proliferation;negative regulation of protein catabolic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transforming growth factor beta receptor signaling pathway;negative regulation of wound healing;nodal signaling pathway;osteoblast development;paraxial mesoderm morphogenesis;pericardium development;positive regulation of alkaline phosphatase activity;positive regulation of bone mineralization;positive regulation of catenin import into nucleus;positive regulation of cell migration;positive regulation of chondrocyte differentiation;positive regulation of epithelial to mesenchymal transition;positive regulation of extracellular matrix assembly;positive regulation of focal adhesion assembly;positive regulation of gene expression;positive regulation of interleukin-1 beta production;positive regulation of nitric oxide biosynthetic process;positive regulation of positive chemotaxis;positive regulation of pri-miRNA transcription from RNA polymerase II promoter;positive regulation of SMAD protein import into nucleus;positive regulation of stress fiber assembly;positive regulation of transcription factor import into nucleus;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of transforming growth factor beta3 production;primary miRNA processing;protein deubiquitination;protein stabilization;regulation of binding;regulation of epithelial cell proliferation;regulation of immune response;regulation of striated muscle tissue development;regulation of transcription from RNA polymerase II promoter;regulation of transforming growth factor beta receptor signaling pathway;regulation of transforming growth factor beta2 production;response to hypoxia;signal transduction involved in regulation of gene expression;SMAD protein complex assembly;SMAD protein signal transduction;somitogenesis;T cell activation;thyroid gland development;transcription, DNA-templated;transdifferentiation;transforming growth factor beta receptor signaling pathway;ureteric bud development;wound healing","beta-catenin binding;bHLH transcription factor binding;chromatin DNA binding;collagen binding;co-SMAD binding;DEAD/H-box RNA helicase binding;DNA binding transcription factor activity;enhancer binding;glucocorticoid receptor binding;identical protein binding;mineralocorticoid receptor binding;phosphatase binding;primary miRNA binding;protein heterodimerization activity;protein homodimerization activity;protein kinase binding;proximal promoter sequence-specific DNA binding;RNA polymerase II activating transcription factor binding;RNA polymerase II proximal promoter sequence-specific DNA binding;R-SMAD binding;sequence-specific DNA binding;transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding;transcription factor binding;transcription regulatory region DNA binding;transforming growth factor beta receptor binding;transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity;ubiquitin binding;ubiquitin protein ligase binding;zinc ion binding","cytoplasm;cytosol;heteromeric SMAD protein complex;nuclear chromatin;nuclear inner membrane;nucleoplasm;nucleus;plasma membrane;receptor complex;SMAD protein complex;transcription factor complex","Adherens junction;AGE-RAGE signaling pathway in diabetic complications;Apelin signaling pathway;Cell cycle;Cellular senescence;Chagas disease (American trypanosomiasis);Chronic myeloid leukemia;Colorectal cancer;Endocytosis;FoxO signaling pathway;Gastric cancer;Hepatitis B;Hepatocellular carcinoma;Hippo signaling pathway;Human T-cell leukemia virus 1 infection;Inflammatory bowel disease (IBD);Pancreatic cancer;Pathways in cancer;Relaxin signaling pathway;Signaling pathways regulating pluripotency of stem cells;TGF-beta signaling pathway;Th17 cell differentiation;Wnt signaling pathway",null,null,3,3,2,8,8,"4.9","48.08","0.00025981","7.2003",49639000,12,"0.0587016",1,"-0.325323","-0.180243","sp|P84022|SMAD3_HUMAN;tr|H0YMP2|H0YMP2_HUMAN;tr|H0YL71|H0YL71_HUMAN;tr|H3BP09|H3BP09_HUMAN;tr|H3BQ00|H3BQ00_HUMAN;tr|H3BVD1|H3BVD1_HUMAN;tr|K7EJX0|K7EJX0_HUMAN;sp|O15198|SMAD9_HUMAN","sp|P84022|SMAD3_HUMAN",2007,"P84022","SMAD3_HUMAN","Mothers against decapentaplegic homolog 3","AD homolog 3;ad3;MAD-3;others against DPP homolog 3","SMAD3"]
["19.3673","20.3812","20.0125","20.3933",{"$nulls":3},"cytoplasmic microtubule organization;cytoskeleton-dependent intracellular transport;early endosome to late endosome transport;endosome organization;endosome to lysosome transport;lysosome organization;multicellular organism development;protein transport;spermatid development","actin binding;dynein light intermediate chain binding;identical protein binding;microtubule binding","centrosome;cytosol;FHF complex;microtubule",{"$nulls":3},17,17,17,"28.8","28.8","28.8","84.647",0,"62.689",445060000,56,"0.217782",1,"-0.328647","-0.606886","sp|Q9UJC3|HOOK1_HUMAN","sp|Q9UJC3|HOOK1_HUMAN",4764,"Q9UJC3","HOOK1_HUMAN","Protein Hook homolog 1","HK1;-hook1","HOOK1"]
["16.5272","19.2773","16.9527","19.5152",{"$nulls":3},"3'-UTR-mediated mRNA stabilization;activation of MAPK activity;angiogenesis;apoptotic process;cartilage condensation;cell morphogenesis;cell surface receptor signaling pathway;cellular response to ionizing radiation;cellular response to lipopolysaccharide;cellular response to lipoteichoic acid;cellular response to tumor necrosis factor;cellular response to vascular endothelial growth factor stimulus;cellular response to virus;chemotaxis;chondrocyte differentiation;DNA damage checkpoint;fatty acid oxidation;glucose metabolic process;intracellular signal transduction;lipopolysaccharide-mediated signaling pathway;movement of cell or subcellular component;myoblast differentiation involved in skeletal muscle regeneration;negative regulation of canonical Wnt signaling pathway;neutrophil degranulation;osteoclast differentiation;p38MAPK cascade;peptidyl-serine phosphorylation;placenta development;positive regulation of brown fat cell differentiation;positive regulation of cardiac muscle cell proliferation;positive regulation of cyclase activity;positive regulation of cytokine secretion involved in immune response;positive regulation of erythrocyte differentiation;positive regulation of gene expression;positive regulation of glucose import;positive regulation of interleukin-12 secretion;positive regulation of macrophage chemotaxis;positive regulation of metallopeptidase activity;positive regulation of muscle cell differentiation;positive regulation of myoblast differentiation;positive regulation of myoblast fusion;positive regulation of myotube differentiation;positive regulation of protein import into nucleus;positive regulation of reactive oxygen species metabolic process;positive regulation of transcription from RNA polymerase II promoter;Ras protein signal transduction;regulation of cytokine production involved in inflammatory response;regulation of DNA binding transcription factor activity;regulation of ossification;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter;response to muramyl dipeptide;response to muscle stretch;signal transduction;signal transduction in response to DNA damage;skeletal muscle tissue development;stress-induced premature senescence;striated muscle cell differentiation;transcription, DNA-templated;transmembrane receptor protein serine/threonine kinase signaling pathway;vascular endothelial growth factor receptor signaling pathway","ATP binding;enzyme binding;MAP kinase activity;MAP kinase kinase activity;mitogen-activated protein kinase p38 binding;NFAT protein binding;protein phosphatase binding;protein serine/threonine kinase activity","cytoplasm;cytosol;extracellular exosome;extracellular region;ficolin-1-rich granule lumen;mitochondrion;nuclear speck;nucleoplasm;nucleus;secretory granule lumen;spindle pole","Adrenergic signaling in cardiomyocytes;AGE-RAGE signaling pathway in diabetic complications;Amyotrophic lateral sclerosis (ALS);Cellular senescence;Chagas disease (American trypanosomiasis);C-type lectin receptor signaling pathway;Dopaminergic synapse;Endocrine resistance;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;FoxO signaling pathway;GnRH signaling pathway;Hepatitis B;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;IL-17 signaling pathway;Inflammatory mediator regulation of TRP channels;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Leukocyte transendothelial migration;MAPK signaling pathway;Neurotrophin signaling pathway;NOD-like receptor signaling pathway;Oocyte meiosis;Osteoclast differentiation;PD-L1 expression and PD-1 checkpoint pathway in cancer;Pertussis;Platelet activation;Progesterone-mediated oocyte maturation;Prolactin signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Relaxin signaling pathway;Retrograde endocannabinoid signaling;RIG-I-like receptor signaling pathway;Salmonella infection;Shigellosis;Signaling pathways regulating pluripotency of stem cells;Sphingolipid signaling pathway;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thermogenesis;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;VEGF signaling pathway;Yersinia infection",null,null,5,5,5,"21.4","21.4","21.4","41.293",0,"22.199",64029000,8,"0.0574032",1,"-0.331644","-0.176456","sp|Q16539|MK14_HUMAN;tr|B4E0K5|B4E0K5_HUMAN;tr|B5TY33|B5TY33_HUMAN;tr|E7EX54|E7EX54_HUMAN","sp|Q16539|MK14_HUMAN;tr|B4E0K5|B4E0K5_HUMAN",2548,"Q16539","MK14_HUMAN","Mitogen-activated protein kinase 14","AP kinase 14;APK 14","MAPK14"]
["17.9124",1,"18.5767",1,{"$nulls":3},"post-translational protein modification;protein ubiquitination",null,"Cul4-RING E3 ubiquitin ligase complex;nucleoplasm",{"$nulls":3},2,2,2,"12.5","12.5","12.5","24.193","0.00068966","4.6004",14959000,3,"0.00844347",1,"-0.33215","-0.0272344","sp|Q9NXF7|DCA16_HUMAN","sp|Q9NXF7|DCA16_HUMAN",4544,"Q9NXF7","DCA16_HUMAN","DDB1- and CUL4-associated factor 16",null,"DCAF16"]
["18.2158",1,"18.8835",1,{"$nulls":3},"regulation of transcription from RNA polymerase II promoter;RNA processing","DNA binding;RNA binding","nucleoplasm",{"$nulls":3},22,1,1,"62.8","3.2","3.2","41.807","0.0029319","3.2664",49498000,4,"0.00833839",1,"-0.333858","-0.0268986","tr|Q5T6W2|Q5T6W2_HUMAN","tr|Q5T6W2|Q5T6W2_HUMAN",5295,"Q5T6W2","Q5T6W2_HUMAN",null,null,"HNRNPK"]
["22.1836","22.7472","22.5902","23.0121",{"$nulls":3},"COPI coating of Golgi vesicle;ER to Golgi vesicle-mediated transport;Golgi organization;positive regulation of organelle organization;protein transport;retrograde vesicle-mediated transport, Golgi to ER","syntaxin binding","endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular exosome;Golgi apparatus;Golgi membrane;integral component of membrane;trans-Golgi network transport vesicle;transport vesicle",{"$nulls":3},6,5,5,"29.4","22.1","22.1","27.277",0,"46.832",800230000,30,"0.355697",1,"-0.335744","-0.953762","sp|Q9BVK6|TMED9_HUMAN","sp|Q9BVK6|TMED9_HUMAN",4012,"Q9BVK6","TMED9_HUMAN","Transmembrane emp24 domain-containing protein 9",null,"TMED9"]
["16.7406","16.1881","16.0763","17.5245",{"$nulls":3},"cell redox homeostasis;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;negative regulation of protein phosphorylation;positive regulation of ATPase activity;protein folding in endoplasmic reticulum;response to endoplasmic reticulum stress;ubiquitin-dependent ERAD pathway","ATPase activator activity;ATPase binding;chaperone binding;disulfide oxidoreductase activity;Hsp70 protein binding;misfolded protein binding;oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;protein disulfide oxidoreductase activity","endoplasmic reticulum;endoplasmic reticulum chaperone complex;endoplasmic reticulum lumen;membrane","Protein processing in endoplasmic reticulum",null,null,7,7,7,"10.8","10.8","10.8","91.079",0,"19.075",133760000,22,"0.150695",1,"-0.336104","-0.433685","sp|Q8IXB1|DJC10_HUMAN;tr|A0A087WXH7|A0A087WXH7_HUMAN;tr|E7EP04|E7EP04_HUMAN","sp|Q8IXB1|DJC10_HUMAN",3143,"Q8IXB1","DJC10_HUMAN","DnaJ homolog subfamily C member 10",null,"DNAJC10"]
["20.8727","20.9637","21.1963","21.3166",{"$nulls":4},"ATP binding",{"$nulls":4},3,3,1,"25.2","25.2","12.2","16.21",0,"8.4523",179220000,18,"1.33463",1,"-0.338234","-4.48557","tr|C9J2P0|C9J2P0_HUMAN;tr|H7C061|H7C061_HUMAN;tr|B7Z306|B7Z306_HUMAN;sp|P51965|UB2E1_HUMAN;tr|A0A087X283|A0A087X283_HUMAN;tr|C9J180|C9J180_HUMAN","tr|C9J2P0|C9J2P0_HUMAN;tr|H7C061|H7C061_HUMAN;tr|B7Z306|B7Z306_HUMAN;sp|P51965|UB2E1_HUMAN;tr|A0A087X283|A0A087X283_HUMAN",1675,"C9J2P0","C9J2P0_HUMAN",null,null,"UBE2E1"]
["22.437","22.3928","22.8288","22.6804",{"$nulls":3},"platelet degranulation;positive regulation of interferon-gamma production;positive regulation of memory T cell activation;positive regulation of T cell activation;positive regulation of T cell mediated cytotoxicity","MHC class Ib protein binding, via antigen binding groove","cilium;extracellular exosome;extracellular region;membrane;platelet alpha granule lumen",{"$nulls":3},10,10,10,"36.1","36.1","36.1","36.748",0,"88.796",1010400000,48,"1.31721",1,"-0.339688","-4.38994","sp|Q9NUQ9|FA49B_HUMAN;tr|A0A087X178|A0A087X178_HUMAN;tr|E5RI16|E5RI16_HUMAN;tr|E5RJE1|E5RJE1_HUMAN;tr|E5RIR8|E5RIR8_HUMAN;tr|E5RJL8|E5RJL8_HUMAN;tr|E5RK61|E5RK61_HUMAN;tr|E5RFS4|E5RFS4_HUMAN;tr|E5RHU5|E5RHU5_HUMAN;tr|E5RGI7|E5RGI7_HUMAN;sp|Q9H0Q0|FA49A_HUMAN;tr|E5RK81|E5RK81_HUMAN;tr|E5RH75|E5RH75_HUMAN","sp|Q9NUQ9|FA49B_HUMAN;tr|A0A087X178|A0A087X178_HUMAN",4472,"Q9NUQ9","FA49B_HUMAN","Protein FAM49B",null,"FAM49B"]
["19.6892","19.2065","20.3668","19.2111",{"$nulls":3},"mitochondrial tRNA pseudouridine synthesis;mRNA pseudouridine synthesis;tRNA pseudouridine synthesis","pseudouridine synthase activity;pseudouridylate synthase activity;RNA binding","mitochondrial matrix;mitochondrion;nucleus",{"$nulls":3},9,9,9,"29.3","29.3","29.3","47.47",0,"44.373",227200000,21,"0.193381",1,"-0.341038","-0.544578","sp|Q9Y606|TRUA_HUMAN;tr|F5H1S9|F5H1S9_HUMAN;tr|G8JLB3|G8JLB3_HUMAN;tr|F5H168|F5H168_HUMAN;tr|F5GY32|F5GY32_HUMAN;tr|F8W9U5|F8W9U5_HUMAN;tr|F5H1B2|F5H1B2_HUMAN;tr|F5GXL3|F5GXL3_HUMAN","sp|Q9Y606|TRUA_HUMAN;tr|F5H1S9|F5H1S9_HUMAN;tr|G8JLB3|G8JLB3_HUMAN",5069,"Q9Y606","TRUA_HUMAN","tRNA pseudouridine synthase A",null,"PUS1"]
["17.2659","17.0078","17.6164","17.3428",{"$nulls":3},"ERAD pathway;negative regulation of retrograde protein transport, ER to cytosol;transmembrane transport;ubiquitin-dependent ERAD pathway","unfolded protein binding","endoplasmic reticulum lumen;endoplasmic reticulum quality control compartment","Protein processing in endoplasmic reticulum",null,null,2,2,2,"4.6","4.6","4.6","54.858","0.00024925","6.3009",36747000,6,"0.677895",1,"-0.342773","-1.82258","sp|Q96DZ1|ERLEC_HUMAN","sp|Q96DZ1|ERLEC_HUMAN",3656,"Q96DZ1","ERLEC_HUMAN","Endoplasmic reticulum lectin 1",null,"ERLEC1"]
["17.4741","15.6796","17.7087","16.1306",{"$nulls":3},"intra-Golgi vesicle-mediated transport",null,"Golgi apparatus;Golgi membrane;integral component of Golgi membrane;nucleoplasm",{"$nulls":3},20,20,4,36,36,10,"77.454",0,"86.43",424350000,62,"0.0962705",1,"-0.342806","-0.286903","sp|Q13948|CASP_HUMAN","sp|Q13948|CASP_HUMAN",2318,"Q13948","CASP_HUMAN","Protein CASP",null,"CUX1"]
["20.4326","18.5308","20.5359","19.1145",{"$nulls":3},"aerobic respiration;ATP biosynthetic process;mitochondrial respiratory chain complex IV assembly;oxidation-reduction process;oxidative phosphorylation;respiratory chain complex IV assembly","cytochrome-c oxidase activity","integral component of membrane;mitochondrial respiratory chain",{"$nulls":3},4,4,4,"21.3","21.3","21.3","33.331",0,"8.3422",143480000,23,"0.0971589",1,"-0.343515","-0.289364","sp|Q15526|SURF1_HUMAN;tr|A0A087WYS9|A0A087WYS9_HUMAN","sp|Q15526|SURF1_HUMAN;tr|A0A087WYS9|A0A087WYS9_HUMAN",2495,"Q15526","SURF1_HUMAN","Surfeit locus protein 1",null,"SURF1"]
["19.5682","20.3158","19.6983","20.8785",{"$nulls":3},"7-methylguanosine mRNA capping;fibroblast growth factor receptor signaling pathway;mRNA splicing, via spliceosome;positive regulation of gene expression, epigenetic;positive regulation of type I interferon production;positive regulation of viral transcription;regulation of gene silencing by miRNA;regulation of transcription from RNA polymerase I promoter;RNA metabolic process;snRNA transcription from RNA polymerase II promoter;somatic stem cell population maintenance;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription from RNA polymerase III promoter;transcription initiation from RNA polymerase I promoter;transcription initiation from RNA polymerase II promoter;transcription, DNA-templated;transcription-coupled nucleotide-excision repair","DNA binding;DNA-directed 5'-3' RNA polymerase activity;zinc ion binding","cytosol;DNA-directed RNA polymerase I complex;DNA-directed RNA polymerase II, core complex;DNA-directed RNA polymerase III complex;nucleoplasm;nucleus","Cytosolic DNA-sensing pathway;Huntington disease;RNA polymerase",null,null,1,1,1,"13.4","13.4","13.4","7.645","0.0070741","2.4879",24173000,6,"0.174484",1,"-0.346368","-0.495834","sp|P62875|RPAB5_HUMAN","sp|P62875|RPAB5_HUMAN",1919,"P62875","RPAB5_HUMAN","DNA-directed RNA polymerases I, II, and III subunit RPABC5","NA polymerases I, II, and III subunit ABC5","POLR2L"]
["21.7787","20.7818","21.5209","21.735",{"$nulls":3},"cellular response to drug;mRNA processing;mRNA splicing, via spliceosome;response to cocaine;RNA splicing","GTP binding;GTPase activity;RNA binding","Cajal body;catalytic step 2 spliceosome;cytosol;extracellular matrix;membrane;nuclear speck;nucleoplasm;spliceosomal complex;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,45,44,44,"60.5","59.5","59.5","109.43",0,"323.31",7483000000,494,"0.247466",1,"-0.347682","-0.681986","sp|Q15029|U5S1_HUMAN;tr|K7EP67|K7EP67_HUMAN;tr|K7EJ74|K7EJ74_HUMAN;tr|K7EIT3|K7EIT3_HUMAN;tr|K7EIV5|K7EIV5_HUMAN","sp|Q15029|U5S1_HUMAN",2431,"Q15029","U5S1_HUMAN","116 kDa U5 small nuclear ribonucleoprotein component",null,"EFTUD2"]
["19.985","17.9531","19.6846","18.9518",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination",null,"mitochondrial inner membrane;mitochondrial small ribosomal subunit","Ribosome",null,null,4,4,4,"20.4","20.4","20.4","22.999",0,"11.39",96638000,11,"0.109504",1,"-0.349171","-0.323312","sp|P82664|RT10_HUMAN","sp|P82664|RT10_HUMAN",1990,"P82664","RT10_HUMAN","28S ribosomal protein S10, mitochondrial","10mt;RP-S10","MRPS10"]
["19.8594","18.8837","20.4194","19.0253",{"$nulls":9},3,3,3,"22.2","22.2","22.2","20.012","0.00023832","5.3793",34047000,4,"0.142614",1,"-0.350816","-0.412338","sp|Q8N5M4|TTC9C_HUMAN;tr|H0YDR3|H0YDR3_HUMAN;tr|E9PKV8|E9PKV8_HUMAN;tr|E7EST3|E7EST3_HUMAN","sp|Q8N5M4|TTC9C_HUMAN;tr|H0YDR3|H0YDR3_HUMAN;tr|E9PKV8|E9PKV8_HUMAN",3245,"Q8N5M4","TTC9C_HUMAN","Tetratricopeptide repeat protein 9C","PR repeat protein 9C","TTC9C"]
["20.5433","20.5336","20.8209","20.9623",{"$nulls":3},"brain development;G1 to G0 transition;kidney development;lung development;negative regulation of epithelial cell proliferation;negative regulation of translation;organonitrogen compound catabolic process;response to lipid;response to salt","deaminase activity;endoribonuclease activity, producing 3'-phosphomonoesters;long-chain fatty acid binding;platinum binding;protein homodimerization activity;RNA binding;transition metal ion binding;xenon atom binding","cytoplasm;cytosol;extracellular exosome;mitochondrial matrix;nucleus;peroxisome",{"$nulls":3},2,2,2,19,19,19,"14.494",0,"9.8966",87841000,2,"1.42015",1,"-0.353178","-4.98214","sp|P52758|UK114_HUMAN;tr|H0YBX3|H0YBX3_HUMAN;tr|H0YB34|H0YB34_HUMAN","sp|P52758|UK114_HUMAN;tr|H0YBX3|H0YBX3_HUMAN;tr|H0YB34|H0YB34_HUMAN",1694,"P52758","RIDA_HUMAN","2-iminobutanoate/2-iminopropanoate deaminase {ECO:0000305|PubMed:22094463}",null,"RIDA"]
["19.3189","19.5855","19.6302","19.983",{"$nulls":3},"intrinsic apoptotic signaling pathway in response to oxidative stress;positive regulation of apoptotic process;positive regulation of JNK cascade;positive regulation of kinase activity;positive regulation of MAPK cascade;ribosomal large subunit biogenesis","RNA binding;zinc ion binding","cytosol;cytosolic large ribosomal subunit;Golgi apparatus;nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},9,9,9,"23.7","23.7","23.7","54.271",0,"25.779",230010000,33,"0.601821",1,"-0.354413","-1.6029","sp|Q969S3|ZN622_HUMAN","sp|Q969S3|ZN622_HUMAN",3582,"Q969S3","ZN622_HUMAN","Zinc finger protein 622",null,"ZNF622"]
["20.6156","20.2601","20.7757","20.8092",{"$nulls":5},"cytosol",{"$nulls":3},22,22,22,"26.7","26.7","26.7","101.2",0,"75.33",741890000,58,"0.731886",1,"-0.354614","-1.98615","tr|A0A0B4J1W3|A0A0B4J1W3_HUMAN;sp|Q9BXJ9|NAA15_HUMAN;sp|Q6N069|NAA16_HUMAN","tr|A0A0B4J1W3|A0A0B4J1W3_HUMAN;sp|Q9BXJ9|NAA15_HUMAN",4043,"A0A0B4J1W3","A0A0B4J1W3_HUMAN",null,null,"NAA15"]
["18.2135","16.938","18.4837","17.3784",{"$nulls":3},"immune system process",null,"cytosol;nucleoplasm",{"$nulls":3},3,3,3,"6.2","6.2","6.2","66.755","0.00024938","6.3107",44856000,7,"0.145906",1,"-0.355317","-0.421051","sp|Q96RS6|NUDC1_HUMAN","sp|Q96RS6|NUDC1_HUMAN",3808,"Q96RS6","NUDC1_HUMAN","NudC domain-containing protein 1",null,"NUDCD1"]
["18.189","18.1183","18.1045","18.9173",{"$nulls":3},"mRNA splicing, via spliceosome;RNA splicing, via transesterification reactions","metal ion binding;RNA binding;RNA lariat debranching enzyme activity","nucleus",{"$nulls":3},6,6,6,"13.1","13.1","13.1","61.554",0,"12.88",102840000,12,"0.324635",1,"-0.357241","-0.875686","sp|Q9UK59|DBR1_HUMAN;tr|F8WAY1|F8WAY1_HUMAN","sp|Q9UK59|DBR1_HUMAN",4777,"Q9UK59","DBR1_HUMAN","Lariat debranching enzyme",null,"DBR1"]
["18.994","19.2021","21.3531","17.5597",{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},7,7,7,31,31,31,"23.864",0,"141.01",1115300000,58,"0.0616031",1,"-0.358405","-0.188681","sp|Q96EY4|TMA16_HUMAN;tr|H0Y9X1|H0Y9X1_HUMAN;tr|D6RA57|D6RA57_HUMAN;tr|D6RE67|D6RE67_HUMAN;tr|D6RC31|D6RC31_HUMAN","sp|Q96EY4|TMA16_HUMAN;tr|H0Y9X1|H0Y9X1_HUMAN;tr|D6RA57|D6RA57_HUMAN",3676,"Q96EY4","TMA16_HUMAN","Translation machinery-associated protein 16",null,"TMA16"]
["18.0584","16.7321","17.7146","17.7939",{"$nulls":3},"cellular protein modification process;collagen catabolic process;endodermal cell differentiation;extracellular matrix disassembly;proteolysis;response to estradiol","enzyme activator activity;metalloaminopeptidase activity;metalloendopeptidase activity;zinc ion binding","extracellular matrix;integral component of plasma membrane;plasma membrane","Parathyroid hormone synthesis, secretion and action",null,null,5,5,5,"12.3","12.3","12.3","75.806",0,"29.52",95746000,11,"0.191776",1,"-0.359035","-0.540458","sp|P51511|MMP15_HUMAN","sp|P51511|MMP15_HUMAN",1651,"P51511","MMP15_HUMAN","Matrix metalloproteinase-15","MP-15","MMP15"]
["24.9538","24.4869","25.1051","25.0562",{"$nulls":3},"ERBB2 signaling pathway;positive regulation of mitophagy in response to mitochondrial depolarization;posttranscriptional regulation of gene expression;protein folding;protein stabilization;protein targeting;regulation of cyclin-dependent protein serine/threonine kinase activity;regulation of interferon-gamma-mediated signaling pathway;regulation of type I interferon-mediated signaling pathway","chaperone binding;heat shock protein binding;Hsp90 protein binding;kinase binding;protein kinase binding;protein kinase regulator activity;protein tyrosine kinase activity;unfolded protein binding","cytoplasm;cytosol;extracellular exosome;HSP90-CDC37 chaperone complex","PI3K-Akt signaling pathway",null,null,12,12,12,"36.8","36.8","36.8","44.468",0,"251.93",3895700000,90,"0.577609",1,"-0.360354","-1.53532","sp|Q16543|CDC37_HUMAN;tr|K7EQA9|K7EQA9_HUMAN;tr|K7EKQ2|K7EKQ2_HUMAN;tr|K7EL68|K7EL68_HUMAN;tr|K7EIU0|K7EIU0_HUMAN;tr|K7EJ06|K7EJ06_HUMAN","sp|Q16543|CDC37_HUMAN;tr|K7EQA9|K7EQA9_HUMAN;tr|K7EKQ2|K7EKQ2_HUMAN",2549,"Q16543","CDC37_HUMAN","Hsp90 co-chaperone Cdc37",null,"CDC37"]
["18.4184","17.2929","18.5459","17.8966",{"$nulls":3},"autophagy;negative regulation of endocytosis;positive regulation of autophagosome assembly;positive regulation of xenophagy;protein autoubiquitination;protein catabolic process;protein polyubiquitination;signal transduction;ubiquitin-dependent endocytosis;viral budding","metal ion binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;membrane;plasma membrane",{"$nulls":3},7,7,7,"14.5","14.5","14.5","83.593",0,"16.829",86442000,9,"0.200459",1,"-0.365582","-0.562718","sp|Q6UWE0|LRSM1_HUMAN","sp|Q6UWE0|LRSM1_HUMAN",2904,"Q6UWE0","LRSM1_HUMAN","E3 ubiquitin-protein ligase LRSAM1 {ECO:0000305}",null,"LRSAM1"]
["18.9992","17.7679","18.5405","18.9602",{"$nulls":3},"transcription, DNA-templated;transforming growth factor beta receptor signaling pathway","DNA binding;DNA binding transcription factor activity","centrosome;cytosol;nucleoplasm;transcription factor complex",{"$nulls":3},3,3,3,"8.1","8.1","8.1","50.052",0,"19.107",60985000,9,"0.200938",1,"-0.366802","-0.563943","tr|K7EIU8|K7EIU8_HUMAN;sp|Q13485|SMAD4_HUMAN;tr|K7ELK2|K7ELK2_HUMAN;tr|A0A087WUF3|A0A087WUF3_HUMAN","tr|K7EIU8|K7EIU8_HUMAN;sp|Q13485|SMAD4_HUMAN",2265,"K7EIU8","K7EIU8_HUMAN","Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195}","AD homolog {ECO:0000256|RuleBase:RU361195};others against DPP homolog {ECO:0000256|RuleBase:RU361195}","SMAD4"]
["25.015","24.0421","25.2189","24.5751",{"$nulls":3},"3'-UTR-mediated mRNA destabilization;cellular response to amino acid stimulus;cellular response to estradiol stimulus;cellular response to nitric oxide;cellular response to putrescine;cerebellum development;circadian regulation of translation;hepatocyte dedifferentiation;liver development;mRNA splicing, via spliceosome;mRNA stabilization;mRNA transcription from RNA polymerase II promoter;positive regulation of gene expression;positive regulation of telomerase RNA reverse transcriptase activity;positive regulation of telomere capping;positive regulation of transcription, DNA-templated;positive regulation of translation;regulation of circadian rhythm;regulation of mRNA stability;regulation of telomere maintenance;regulation of transcription, DNA-templated;response to calcium ion;response to drug;response to electrical stimulus;response to rapamycin;response to sodium phosphate;RNA catabolic process;RNA metabolic process;RNA processing;transcription, DNA-templated","AT DNA binding;chromatin binding;histone deacetylase binding;mRNA 3'-UTR AU-rich region binding;RNA binding;telomeric DNA binding;transcription factor binding","cytosol;extracellular exosome;intracellular ribonucleoprotein complex;nucleoplasm;nucleus",{"$nulls":3},12,12,11,"36.9","36.9","34.6","38.434",0,"206.1",3476300000,76,"0.227526",1,"-0.368421","-0.631609","sp|Q14103|HNRPD_HUMAN;tr|H0Y8G5|H0Y8G5_HUMAN;tr|H0YA96|H0YA96_HUMAN;tr|D6RAF8|D6RAF8_HUMAN;tr|D6RD83|D6RD83_HUMAN;tr|D6RF44|D6RF44_HUMAN;tr|D6RBQ9|D6RBQ9_HUMAN","sp|Q14103|HNRPD_HUMAN;tr|H0Y8G5|H0Y8G5_HUMAN;tr|H0YA96|H0YA96_HUMAN;tr|D6RAF8|D6RAF8_HUMAN",2326,"Q14103","HNRPD_HUMAN","Heterogeneous nuclear ribonucleoprotein D0","nRNP D0","HNRNPD"]
[1,"13.2962","14.0387",1,{"$nulls":3},"cellular response to DNA damage stimulus;immunoglobulin production;positive regulation of B cell proliferation;positive regulation of isotype switching to IgG isotypes;regulation of mitotic cell cycle phase transition","ATP binding","nucleus",{"$nulls":3},5,5,5,4,4,4,"207.57",0,"10.728",63920000,7,"0.0129064",1,"-0.371232","-0.0414271","sp|Q96QE3|ATAD5_HUMAN;tr|A0A075B754|A0A075B754_HUMAN","sp|Q96QE3|ATAD5_HUMAN;tr|A0A075B754|A0A075B754_HUMAN",3794,"Q96QE3","ATAD5_HUMAN","ATPase family AAA domain-containing protein 5",null,"ATAD5"]
["16.3264","16.9769","17.4175","16.6364",{"$nulls":3},"cell division;meiotic chromosome segregation;mitotic sister chromatid cohesion;negative regulation of chromatin binding;negative regulation of DNA replication;negative regulation of sister chromatid cohesion;positive regulation of fibroblast proliferation;protein localization to chromatin;regulation of chromosome condensation;regulation of cohesin loading;response to toxic substance;sister chromatid cohesion;viral process",null,"chromatin;chromosome;chromosome, centromeric region;cohesin complex;cytoplasm;cytosol;nucleoplasm;nucleus;synaptonemal complex",{"$nulls":3},5,5,5,"6.7","6.7","6.7","132.94",0,"10.252",78419000,14,"0.269878",1,"-0.375274","-0.73836","sp|Q7Z5K2|WAPL_HUMAN;tr|Q8WVX6|Q8WVX6_HUMAN","sp|Q7Z5K2|WAPL_HUMAN",3010,"Q7Z5K2","WAPL_HUMAN","Wings apart-like protein homolog",null,"WAPL"]
["17.7817","17.7666","18.1216","18.1797",{"$nulls":3},"astral microtubule organization;cell division;ciliary basal body-plasma membrane docking;establishment of epithelial cell polarity;establishment of mitotic spindle localization;establishment of spindle orientation;establishment or maintenance of cell polarity;exit from mitosis;G2/M transition of mitotic cell cycle;Golgi organization;microtubule anchoring;microtubule bundle formation;microtubule cytoskeleton organization;microtubule nucleation;microtubule organizing center organization;mitotic spindle assembly;mitotic spindle organization;negative regulation of microtubule depolymerization;negative regulation of microtubule polymerization or depolymerization;negative regulation of stress fiber assembly;negative regulation of wound healing, spreading of epidermal cells;positive regulation of basement membrane assembly involved in embryonic body morphogenesis;positive regulation of epithelial cell migration;positive regulation of exocytosis;positive regulation of extracellular matrix disassembly;positive regulation of microtubule polymerization;regulation of epithelial to mesenchymal transition;regulation of focal adhesion assembly;regulation of G2/M transition of mitotic cell cycle;regulation of gastrulation;regulation of microtubule cytoskeleton organization;sister chromatid cohesion;vesicle targeting","dystroglycan binding;kinetochore binding;microtubule binding;microtubule plus-end binding","basal cortex;cell cortex;centrosomal corona;centrosome;condensed chromosome kinetochore;cortical microtubule cytoskeleton;cytoplasmic microtubule;cytosol;extracellular exosome;Golgi apparatus;kinetochore;kinetochore microtubule;membrane;microtubule plus-end;spindle microtubule",{"$nulls":3},16,14,14,"14.3","12.8","12.8","169.45",0,"40.394",271610000,48,"2.20129",1,"-0.376492","-12.5484","sp|Q7Z460|CLAP1_HUMAN;tr|F8WA11|F8WA11_HUMAN;tr|H0Y5T1|H0Y5T1_HUMAN;tr|C9JP76|C9JP76_HUMAN;tr|C9J151|C9J151_HUMAN","sp|Q7Z460|CLAP1_HUMAN;tr|F8WA11|F8WA11_HUMAN;tr|H0Y5T1|H0Y5T1_HUMAN",2999,"Q7Z460","CLAP1_HUMAN","CLIP-associating protein 1",null,"CLASP1"]
["20.7884","21.5974","21.0238","22.1159",{"$nulls":3},"cholesterol biosynthetic process via 24,25-dihydrolanosterol","heme binding;iron ion binding;sterol 14-demethylase activity","endoplasmic reticulum;integral component of membrane","Metabolic pathways;Steroid biosynthesis",null,null,15,15,15,"39.3","39.3","39.3","57.278",0,"80.05",800970000,72,"0.197352",1,"-0.376992","-0.554762","tr|A0A0C4DFL7|A0A0C4DFL7_HUMAN;sp|Q16850|CP51A_HUMAN;tr|H7C0D0|H7C0D0_HUMAN;tr|C9IYR8|C9IYR8_HUMAN","tr|A0A0C4DFL7|A0A0C4DFL7_HUMAN;sp|Q16850|CP51A_HUMAN",5147,"A0A0C4DFL7","A0A0C4DFL7_HUMAN",null,null,"CYP51A1"]
["17.4422","16.3002","17.4092","17.0971",{"$nulls":3},"actin cytoskeleton reorganization;cell proliferation;positive regulation of cell migration;positive regulation of NF-kappaB transcription factor activity;regulation of epidermal growth factor receptor signaling pathway","ATP binding;epidermal growth factor receptor binding;non-membrane spanning protein tyrosine kinase activity",{"$nulls":4},3,3,3,"7.8","7.8","7.8","46.954","0.00067751","4.3001",28621000,3,"0.232902",1,"-0.381929","-0.645216","tr|W0S4B9|W0S4B9_HUMAN;sp|P16591|FER_HUMAN","tr|W0S4B9|W0S4B9_HUMAN;sp|P16591|FER_HUMAN",1085,"W0S4B9","W0S4B9_HUMAN","Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096}",null,"Pe1Fe10"]
["19.7826","20.1267","20.524","20.1514",{"$nulls":3},"adherens junction maintenance;bundle of His cell-Purkinje myocyte adhesion involved in cell communication;cardiac muscle cell action potential;cardiac muscle cell action potential involved in contraction;cell communication by electrical coupling involved in cardiac conduction;cell-cell adhesion;cell-cell signaling involved in cardiac conduction;cornification;desmosome assembly;gap junction assembly;heart development;intermediate filament bundle assembly;keratinization;lipid homeostasis;maintenance of animal organ identity;negative regulation of cell migration;negative regulation of cell proliferation;positive regulation of sodium ion transport;protein localization to plasma membrane;regulation of bicellular tight junction assembly;regulation of heart rate by cardiac conduction;regulation of ventricular cardiac muscle cell action potential;ventricular cardiac muscle cell action potential;ventricular cardiac muscle tissue morphogenesis","alpha-catenin binding;cadherin binding;cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;intermediate filament binding;ion channel binding;protein complex scaffold activity;protein kinase C binding;sodium channel regulator activity","adherens junction;cell junction;cell-cell junction;cornified envelope;desmosome;integral component of membrane;intercalated disc;intermediate filament;nucleoplasm;nucleus;plasma membrane","Arrhythmogenic right ventricular cardiomyopathy (ARVC)",null,null,25,25,25,39,39,39,"97.414",0,"189.25",2301300000,159,"0.568677",1,"-0.383073","-1.51066","sp|Q99959|PKP2_HUMAN;tr|B8QGS9|B8QGS9_HUMAN;tr|A0A087WXY2|A0A087WXY2_HUMAN","sp|Q99959|PKP2_HUMAN;tr|B8QGS9|B8QGS9_HUMAN",3896,"Q99959","PKP2_HUMAN","Plakophilin-2",null,"PKP2"]
["20.7701","20.2887","21.1233","20.7024",{"$nulls":3},"cell morphogenesis;COPII vesicle coating;negative regulation of autophagosome assembly;phagocytosis;post-Golgi vesicle-mediated transport;protein transport;regulation of ER to Golgi vesicle-mediated transport;regulation of protein transport;response to hypoxia;response to toxic substance;retrograde vesicle-mediated transport, Golgi to ER;toxin transport;vesicle docking involved in exocytosis","protein N-terminus binding;syntaxin binding","cis-Golgi network;cytosol;endoplasmic reticulum membrane;Golgi cisterna membrane;Golgi transport complex;Golgi-associated vesicle;plasma membrane",{"$nulls":3},16,16,16,"35.5","35.5","35.5","72.379",0,"89.81",624410000,35,"0.451931",1,"-0.383436","-1.19925","sp|Q8WVM8|SCFD1_HUMAN;tr|J3KNG4|J3KNG4_HUMAN;tr|G3V2M8|G3V2M8_HUMAN;tr|G3V4I1|G3V4I1_HUMAN;tr|G3V363|G3V363_HUMAN;tr|H0YJS6|H0YJS6_HUMAN;tr|G3V5F3|G3V5F3_HUMAN;tr|H0YIZ7|H0YIZ7_HUMAN;tr|G3V3K9|G3V3K9_HUMAN;tr|H0YJY1|H0YJY1_HUMAN","sp|Q8WVM8|SCFD1_HUMAN",3441,"Q8WVM8","SCFD1_HUMAN","Sec1 family domain-containing protein 1",null,"SCFD1"]
["20.2949",1,"21.0628",1,{"$nulls":3},"deadenylation-dependent decapping of nuclear-transcribed mRNA;exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;histone mRNA catabolic process;mRNA processing;negative regulation of neuron differentiation;RNA splicing;RNA splicing, via transesterification reactions;stem cell population maintenance","mRNA binding;pre-mRNA binding;RNA binding;RNA cap binding","axon;cytoplasm;cytosol;dendrite;Lsm1-7-Pat1 complex;messenger ribonucleoprotein complex;mRNA cap binding complex;neuronal cell body;nucleus;P-body","RNA degradation",null,null,1,1,1,12,12,12,"15.179","0.00067858","4.3256",27426000,3,"0.00855411",1,"-0.38396","-0.0275879","sp|O15116|LSM1_HUMAN","sp|O15116|LSM1_HUMAN",324,"O15116","LSM1_HUMAN","U6 snRNA-associated Sm-like protein LSm1",null,"LSM1"]
["20.5793","16.9452","20.5829","17.7122",{"$nulls":3},"box H/ACA snoRNP assembly;positive regulation of telomerase activity;positive regulation of telomerase RNA localization to Cajal body;positive regulation of telomere maintenance via telomerase;positive regulation of telomere maintenance via telomere lengthening;ribosome biogenesis;RNA stabilization;snoRNA guided rRNA pseudouridine synthesis;telomerase holoenzyme complex assembly;telomerase RNA stabilization","RNA binding;telomerase RNA binding","cytoplasm;nucleus;small nucleolar ribonucleoprotein complex",{"$nulls":3},3,3,3,"7.1","7.1","7.1","53.716",0,"15.542",184960000,22,"0.0539606",1,"-0.385256","-0.166376","sp|Q96HR8|NAF1_HUMAN;tr|D6RIB3|D6RIB3_HUMAN","sp|Q96HR8|NAF1_HUMAN",3721,"Q96HR8","NAF1_HUMAN","H/ACA ribonucleoprotein complex non-core subunit NAF1","NAF1","NAF1"]
["24.9924","24.8233","25.2659","25.3227",{"$nulls":3},"cytoplasmic translation;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","RNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit;extracellular exosome;focal adhesion;membrane","Ribosome",null,null,6,6,6,40,40,40,"14.463",0,"61.474",29188000000,365,"1.30664",1,"-0.386423","-4.33274","sp|P62899|RL31_HUMAN;tr|H7C2W9|H7C2W9_HUMAN;tr|C9JU56|C9JU56_HUMAN;tr|B7Z4E3|B7Z4E3_HUMAN;tr|B7Z4C8|B7Z4C8_HUMAN;tr|B8ZZK4|B8ZZK4_HUMAN","sp|P62899|RL31_HUMAN;tr|H7C2W9|H7C2W9_HUMAN;tr|C9JU56|C9JU56_HUMAN;tr|B7Z4E3|B7Z4E3_HUMAN;tr|B7Z4C8|B7Z4C8_HUMAN;tr|B8ZZK4|B8ZZK4_HUMAN",1924,"P62899","RL31_HUMAN","60S ribosomal protein L31",null,"RPL31"]
["24.0419","24.0755","24.3549","24.5369",{"$nulls":3},"cholesterol biosynthetic process;farnesyl diphosphate biosynthetic process;geranyl diphosphate biosynthetic process;regulation of cholesterol biosynthetic process;viral process","dimethylallyltranstransferase activity;geranyltranstransferase activity;metal ion binding;RNA binding","cytoplasm;cytosol;mitochondrion;nucleoplasm","Human T-cell leukemia virus 1 infection;Influenza A;Metabolic pathways;Terpenoid backbone biosynthesis",null,null,10,10,10,"33.7","33.7","33.7","48.275",0,"83.921",3749500000,107,"1.27849",1,"-0.387149","-4.18353","sp|P14324|FPPS_HUMAN;tr|A0A087WVN4|A0A087WVN4_HUMAN;tr|A0A087X1D8|A0A087X1D8_HUMAN;tr|A0A087X090|A0A087X090_HUMAN;tr|A0A087WTP2|A0A087WTP2_HUMAN","sp|P14324|FPPS_HUMAN;tr|A0A087WVN4|A0A087WVN4_HUMAN;tr|A0A087X1D8|A0A087X1D8_HUMAN;tr|A0A087X090|A0A087X090_HUMAN",1040,"P14324","FPPS_HUMAN","Farnesyl pyrophosphate synthase","PP synthase;PS","FDPS"]
["23.2018","22.633","23.4871","23.1221",{"$nulls":3},"amino acid transport;glutamine secretion;glutamine transport;L-glutamine import across plasma membrane;neutral amino acid transport","amino acid transmembrane transporter activity;L-glutamine transmembrane transporter activity;L-serine transmembrane transporter activity;neutral amino acid transmembrane transporter activity;receptor activity;symporter activity;virus receptor activity","extracellular exosome;integral component of plasma membrane;melanosome;membrane;plasma membrane","Central carbon metabolism in cancer;Protein digestion and absorption",null,null,9,9,9,"25.3","25.3","25.3","56.598",0,"78.27",1679500000,51,"0.431244",1,"-0.387234","-1.14583","sp|Q15758|AAAT_HUMAN;tr|M0QXM4|M0QXM4_HUMAN;tr|M0QX44|M0QX44_HUMAN","sp|Q15758|AAAT_HUMAN;tr|M0QXM4|M0QXM4_HUMAN",2519,"Q15758","AAAT_HUMAN","Neutral amino acid transporter B(0)","TB(0)","SLC1A5"]
["18.5276","18.4202","18.8966","18.8302",{"$nulls":3},"cellular protein modification process;epidermis development;hydroxylysine biosynthetic process;oxidation-reduction process;peptidyl-lysine hydroxylation;response to hypoxia","iron ion binding;L-ascorbic acid binding;procollagen-lysine 5-dioxygenase activity;protein homodimerization activity","catalytic complex;endoplasmic reticulum membrane;extracellular exosome;rough endoplasmic reticulum membrane","Lysine degradation",null,null,9,9,9,"18.4","18.4","18.4","83.549",0,"24.445",157670000,13,"1.59741",1,"-0.389475","-6.1709","sp|Q02809|PLOD1_HUMAN;tr|Q5JXB7|Q5JXB7_HUMAN;tr|Q5JXB8|Q5JXB8_HUMAN","sp|Q02809|PLOD1_HUMAN",2071,"Q02809","PLOD1_HUMAN","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1",null,"PLOD1"]
["18.2831","17.9647","17.9162","19.1108",{"$nulls":3},"maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA processing","RNA binding","cytoplasm;intercellular bridge;membrane;nucleolus;nucleoplasm;nucleus;small-subunit processome",{"$nulls":3},7,7,7,"23.6","23.6","23.6","43.664",0,"19.773",288310000,39,"0.226991",1,"-0.3896","-0.630252","sp|Q13601|KRR1_HUMAN;tr|A0A087WZC7|A0A087WZC7_HUMAN","sp|Q13601|KRR1_HUMAN;tr|A0A087WZC7|A0A087WZC7_HUMAN",2287,"Q13601","KRR1_HUMAN","KRR1 small subunit processome component homolog",null,"KRR1"]
["19.5404","18.7074","19.6954","19.3366",{"$nulls":3},"DNA replication initiation;DNA replication, synthesis of RNA primer;G1/S transition of mitotic cell cycle;telomere maintenance via semi-conservative replication","DNA primase activity;metal ion binding;single-stranded DNA binding","alpha DNA polymerase:primase complex;membrane;nucleoplasm","DNA replication",null,null,3,3,3,"12.6","12.6","12.6","49.901",0,"14.901",199660000,15,"0.320255",1,"-0.392157","-0.8647","sp|P49642|PRI1_HUMAN;tr|F8VNY2|F8VNY2_HUMAN;tr|F8VSB2|F8VSB2_HUMAN","sp|P49642|PRI1_HUMAN;tr|F8VNY2|F8VNY2_HUMAN",1585,"P49642","PRI1_HUMAN","DNA primase small subunit",null,"PRIM1"]
["22.1652","22.61","22.6648","22.8953",{"$nulls":3},"cellular response to calcium ion;glycerophospholipid biosynthetic process;lipid metabolic process;negative regulation of DNA binding;negative regulation of gene expression;negative regulation of NIK/NF-kappaB signaling;neuron projection extension;neutrophil degranulation;positive regulation of neuron differentiation;positive regulation of protein kinase B signaling;positive regulation of tumor necrosis factor-mediated signaling pathway;proteolysis;regulation of I-kappaB kinase/NF-kappaB signaling;regulation of transcription, DNA-templated;transcription, DNA-templated;vesicle-mediated transport","calcium ion binding;calcium-dependent phospholipid binding;endopeptidase activity;NF-kappaB binding;phosphatidylserine binding;protein homodimerization activity;transporter activity","azurophil granule membrane;cytoplasm;cytosol;extracellular exosome;membrane;nuclear membrane;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},14,14,14,"33.3","33.3","33.3","59.058",0,"109.85",983480000,59,"0.588951",1,"-0.392428","-1.56685","sp|Q99829|CPNE1_HUMAN;tr|B0QZ18|B0QZ18_HUMAN;tr|F2Z2V0|F2Z2V0_HUMAN;tr|A6PVH9|A6PVH9_HUMAN;tr|E7ENH5|E7ENH5_HUMAN;tr|Q5JX58|Q5JX58_HUMAN;tr|Q5JX59|Q5JX59_HUMAN;tr|Q5JX60|Q5JX60_HUMAN;tr|Q5JX44|Q5JX44_HUMAN;tr|Q5JX45|Q5JX45_HUMAN;tr|Q5JX56|Q5JX56_HUMAN;tr|Q5JX55|Q5JX55_HUMAN;tr|H0Y524|H0Y524_HUMAN;tr|Q5JX61|Q5JX61_HUMAN;tr|Q5JX52|Q5JX52_HUMAN;tr|Q5JX54|Q5JX54_HUMAN;tr|Q5JX57|Q5JX57_HUMAN;tr|E7EV27|E7EV27_HUMAN","sp|Q99829|CPNE1_HUMAN;tr|B0QZ18|B0QZ18_HUMAN;tr|F2Z2V0|F2Z2V0_HUMAN;tr|A6PVH9|A6PVH9_HUMAN;tr|E7ENH5|E7ENH5_HUMAN;tr|Q5JX58|Q5JX58_HUMAN;tr|Q5JX59|Q5JX59_HUMAN;tr|Q5JX60|Q5JX60_HUMAN;tr|Q5JX44|Q5JX44_HUMAN;tr|Q5JX45|Q5JX45_HUMAN",3888,"Q99829","CPNE1_HUMAN","Copine-1 {ECO:0000305}",null,"CPNE1"]
["17.3521","16.6807","17.3823","17.4384",{"$nulls":4},"heme binding;iron ion binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",{"$nulls":4},1,1,1,"6.7","6.7","6.7","23.323","0.0013024","3.7464",18464000,5,"0.440405",1,"-0.393922","-1.16943","tr|F8WBE2|F8WBE2_HUMAN;tr|C9J8K7|C9J8K7_HUMAN;sp|Q6UW02|CP20A_HUMAN;tr|E9PHG5|E9PHG5_HUMAN","tr|F8WBE2|F8WBE2_HUMAN;tr|C9J8K7|C9J8K7_HUMAN;sp|Q6UW02|CP20A_HUMAN;tr|E9PHG5|E9PHG5_HUMAN",2902,"F8WBE2","F8WBE2_HUMAN",null,null,"CYP20A1"]
["15.8281","16.426","17.0585","15.985",{"$nulls":3},"endoplasmic reticulum membrane fusion;Golgi reassembly;mitotic cell cycle;protein deubiquitination;protein K11-linked deubiquitination;protein K48-linked deubiquitination;protein ubiquitination","thiol-dependent ubiquitin-specific protease activity","cytoplasm;endoplasmic reticulum lumen;Golgi stack",{"$nulls":3},3,3,3,"3.7","3.7","3.7","134.32",0,"15.654",75774000,12,"0.231799",1,"-0.394702","-0.642426","sp|Q96JH7|VCIP1_HUMAN","sp|Q96JH7|VCIP1_HUMAN",3744,"Q96JH7","VCIP1_HUMAN","Deubiquitinating protein VCIP135",null,"VCPIP1"]
["18.0607",1,"18.8584",1,{"$nulls":3},"intrinsic apoptotic signaling pathway by p53 class mediator;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;nucleotide metabolic process;purine nucleotide metabolic process;regulation of transcription, DNA-templated;transcription, DNA-templated","bis(5'-adenosyl)-triphosphatase activity;catalytic activity;hydrolase activity;identical protein binding;nucleotide binding;ubiquitin protein ligase binding","cytoplasm;cytosol;extracellular exosome;fibrillar center;mitochondrion;plasma membrane","Metabolic pathways;Non-small cell lung cancer;Purine metabolism;Small cell lung cancer",null,null,3,3,3,"27.9","27.9","27.9","16.858","0.00024366","5.7867",32506000,2,"0.010031",1,"-0.398852","-0.0322985","sp|P49789|FHIT_HUMAN;tr|A0A0A0MRB0|A0A0A0MRB0_HUMAN;tr|E9PBZ0|E9PBZ0_HUMAN","sp|P49789|FHIT_HUMAN",1601,"P49789","FHIT_HUMAN","Bis(5'-adenosyl)-triphosphatase",null,"FHIT"]
["21.1543","19.4989","21.6149","19.8373",{"$nulls":4},"GTP binding;GTPase activity",{"$nulls":4},2,2,2,13,13,13,"21.214","0.00025569","6.8648",592100000,16,"0.11157",1,"-0.399511","-0.328949","tr|F5H157|F5H157_HUMAN;sp|Q15286|RAB35_HUMAN","tr|F5H157|F5H157_HUMAN;sp|Q15286|RAB35_HUMAN",2467,"F5H157","F5H157_HUMAN",null,null,"RAB35"]
["21.7271","21.3199","22.2898","21.5603",{"$nulls":3},"apoptotic signaling pathway;mitochondrial translational elongation;mitochondrial translational termination","GTP binding;RNA binding;structural constituent of ribosome","mitochondrial inner membrane;mitochondrial small ribosomal subunit;mitochondrion;nucleoplasm",{"$nulls":3},11,11,11,"34.9","34.9","34.9","45.566",0,"141.14",839500000,49,"0.358691",1,"-0.401568","-0.961306","sp|P51398|RT29_HUMAN;tr|V9GZ03|V9GZ03_HUMAN;tr|V9GYJ9|V9GYJ9_HUMAN;tr|V9GYL9|V9GYL9_HUMAN;tr|V9GYA7|V9GYA7_HUMAN;tr|V9GZ61|V9GZ61_HUMAN;tr|V9GYC9|V9GYC9_HUMAN;tr|V9GYW1|V9GYW1_HUMAN;tr|V9GY11|V9GY11_HUMAN;tr|V9GYJ3|V9GYJ3_HUMAN;tr|V9GYF7|V9GYF7_HUMAN","sp|P51398|RT29_HUMAN;tr|V9GZ03|V9GZ03_HUMAN;tr|V9GYJ9|V9GYJ9_HUMAN;tr|V9GYL9|V9GYL9_HUMAN;tr|V9GYA7|V9GYA7_HUMAN",1649,"P51398","RT29_HUMAN","28S ribosomal protein S29, mitochondrial","29mt;RP-S29","DAP3"]
["21.4128","21.259","21.3171","22.1605",{"$nulls":3},"blastocyst formation;mRNA splicing, via spliceosome","RNA binding","catalytic step 2 spliceosome;nucleoplasm;precatalytic spliceosome;U12-type spliceosomal complex;U2 snRNP;U2-type spliceosomal complex","Spliceosome",null,null,4,4,4,"36.8","36.8","36.8","14.585",0,"10.514",284860000,18,"0.350241",1,"-0.40296","-0.940025","sp|Q9Y3B4|SF3B6_HUMAN","sp|Q9Y3B4|SF3B6_HUMAN",4974,"Q9Y3B4","SF3B6_HUMAN","Splicing factor 3B subunit 6",null,"SF3B6"]
["23.951","24.6315","24.8909","24.5044",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;Fc-epsilon receptor signaling pathway;MAPK cascade;negative regulation of canonical Wnt signaling pathway;negative regulation of G2/M transition of mitotic cell cycle;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;NIK/NF-kappaB signaling;positive regulation of canonical Wnt signaling pathway;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein polyubiquitination;regulation of cellular amino acid metabolic process;regulation of hematopoietic stem cell differentiation;regulation of mRNA stability;regulation of transcription from RNA polymerase II promoter in response to hypoxia;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;stimulatory C-type lectin receptor signaling pathway;T cell receptor signaling pathway;transmembrane transport;tumor necrosis factor-mediated signaling pathway;viral process;Wnt signaling pathway, planar cell polarity pathway","threonine-type endopeptidase activity","cytosol;extracellular exosome;intracellular membrane-bounded organelle;nucleoplasm;nucleus;P-body;proteasome complex;proteasome core complex;proteasome core complex, alpha-subunit complex","Proteasome",null,null,11,11,11,"47.9","47.9","47.9","29.483",0,"210.97",2561200000,110,"0.389239",1,"-0.406381","-1.03855","sp|P25789|PSA4_HUMAN;tr|H0YN18|H0YN18_HUMAN;tr|H0YMZ1|H0YMZ1_HUMAN;tr|H0YL69|H0YL69_HUMAN;tr|H0YMA1|H0YMA1_HUMAN;tr|H0YKT8|H0YKT8_HUMAN;tr|H0YMI6|H0YMI6_HUMAN;tr|H0YKS0|H0YKS0_HUMAN;tr|H0YLC2|H0YLC2_HUMAN;tr|H0YLS6|H0YLS6_HUMAN;tr|H0YMV3|H0YMV3_HUMAN","sp|P25789|PSA4_HUMAN;tr|H0YN18|H0YN18_HUMAN;tr|H0YMZ1|H0YMZ1_HUMAN;tr|H0YL69|H0YL69_HUMAN;tr|H0YMA1|H0YMA1_HUMAN;tr|H0YKT8|H0YKT8_HUMAN;tr|H0YMI6|H0YMI6_HUMAN",1230,"P25789","PSA4_HUMAN","Proteasome subunit alpha type-4",null,"PSMA4"]
["15.9025","16.0149","16.7977","15.9331",{"$nulls":3},"activation of store-operated calcium channel activity;cellular calcium ion homeostasis;positive regulation of calcium ion transport;store-operated calcium entry","calcium channel regulator activity;calcium ion binding;store-operated calcium channel activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;plasma membrane","Calcium signaling pathway",null,null,5,5,4,"7.6","7.6","5.8","83.97",0,"11.147",147250000,18,"0.347441",1,"-0.406706","-0.932978","sp|Q9P246|STIM2_HUMAN;tr|H0Y860|H0Y860_HUMAN;tr|H7C5A5|H7C5A5_HUMAN;tr|H7C5K2|H7C5K2_HUMAN;tr|H7C5C6|H7C5C6_HUMAN","sp|Q9P246|STIM2_HUMAN;tr|H0Y860|H0Y860_HUMAN;tr|H7C5A5|H7C5A5_HUMAN;tr|H7C5K2|H7C5K2_HUMAN",4630,"Q9P246","STIM2_HUMAN","Stromal interaction molecule 2",null,"STIM2"]
["20.1433","17.9292","21.1188","17.7692",{"$nulls":3},"canonical glycolysis;glucose metabolic process","ADP-specific glucokinase activity;metal ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular region;membrane","Carbon metabolism;Glycolysis / Gluconeogenesis;Metabolic pathways",null,null,4,4,4,"13.7","13.7","13.7","54.088",0,"35.029",124800000,9,"0.0665871",1,"-0.407722","-0.203088","sp|Q9BRR6|ADPGK_HUMAN;tr|H3BRS6|H3BRS6_HUMAN;tr|H3BU35|H3BU35_HUMAN;tr|H3BTH4|H3BTH4_HUMAN;tr|H3BN66|H3BN66_HUMAN","sp|Q9BRR6|ADPGK_HUMAN;tr|H3BRS6|H3BRS6_HUMAN;tr|H3BU35|H3BU35_HUMAN",3938,"Q9BRR6","ADPGK_HUMAN","ADP-dependent glucokinase","DPGK;DP-GK","ADPGK"]
["13.7525","15.7573","14.8488","15.4847",{"$nulls":3},"transforming growth factor beta receptor signaling pathway","actin binding;cadherin binding;motor activity","bicellular tight junction;cell junction;myosin complex;plasma membrane","Tight junction",null,null,3,3,3,"2.6","2.6","2.6","136.38","0.00046816","4.9381",37710000,3,"0.134829",1,"-0.41186","-0.391641","sp|Q9P2M7|CING_HUMAN","sp|Q9P2M7|CING_HUMAN",4645,"Q9P2M7","CING_HUMAN","Cingulin",null,"CGN"]
["23.2912","22.8591","23.4121","23.5644",{"$nulls":3},"calcium ion homeostasis;endoplasmic reticulum organization;ER overload response;osteoblast differentiation;post-embryonic development;ubiquitin-dependent ERAD pathway","calcium ion binding;RNA binding","endoplasmic reticulum;integral component of membrane;membrane;rough endoplasmic reticulum",{"$nulls":3},26,26,26,47,47,47,"55.873",0,"323.31",14969000000,607,"0.671315",1,"-0.413097","-1.8031","sp|Q96A33|CCD47_HUMAN;tr|A0A087WYW6|A0A087WYW6_HUMAN;tr|J3QR89|J3QR89_HUMAN","sp|Q96A33|CCD47_HUMAN;tr|A0A087WYW6|A0A087WYW6_HUMAN",3591,"Q96A33","CCD47_HUMAN","Coiled-coil domain-containing protein 47",null,"CCDC47"]
["23.4491","22.667","23.6052","23.3444",{"$nulls":3},"cell-cell signaling;circadian regulation of gene expression;circadian rhythm;female pregnancy;NAD biosynthesis via nicotinamide riboside salvage pathway;positive regulation of cell proliferation;positive regulation of nitric-oxide synthase biosynthetic process;positive regulation of smooth muscle cell proliferation;positive regulation of transcription from RNA polymerase II promoter;response to organic cyclic compound;signal transduction","cytokine activity;drug binding;identical protein binding;nicotinamide phosphoribosyltransferase activity;nicotinate-nucleotide diphosphorylase (carboxylating) activity;protein homodimerization activity","cell junction;cytosol;extracellular exosome;nuclear speck","Metabolic pathways;Nicotinate and nicotinamide metabolism;NOD-like receptor signaling pathway",null,null,18,18,18,"52.5","52.5","52.5","55.52",0,"323.31",2585100000,141,"0.37835",1,"-0.416755","-1.01095","sp|P43490|NAMPT_HUMAN;tr|A0A0C4DFS8|A0A0C4DFS8_HUMAN;tr|C9JF35|C9JF35_HUMAN;tr|C9JG65|C9JG65_HUMAN","sp|P43490|NAMPT_HUMAN;tr|A0A0C4DFS8|A0A0C4DFS8_HUMAN",1492,"P43490","NAMPT_HUMAN","Nicotinamide phosphoribosyltransferase","AmPRTase;ampt","NAMPT"]
["18.6654","19.3054","19.3045","19.5045",{"$nulls":3},"intracellular distribution of mitochondria",null,"cytoplasm",{"$nulls":3},25,3,2,"30.3","4.3",3,"138.23",0,"16.839",344980000,20,"0.471504",1,"-0.419139","-1.25021","tr|I3L2B0|I3L2B0_HUMAN;tr|I3L318|I3L318_HUMAN;tr|I3L4B5|I3L4B5_HUMAN;tr|I3L3A3|I3L3A3_HUMAN;tr|I3L350|I3L350_HUMAN","tr|I3L2B0|I3L2B0_HUMAN",5271,"I3L2B0","I3L2B0_HUMAN",null,null,"CLUH"]
[1,"17.1659","18.0046",1,{"$nulls":9},4,1,1,"76.7","32.9","32.9","8.0509",0,"14.692",12880000,2,"0.0111149",1,"-0.419351","-0.0357462","tr|S4R341|S4R341_HUMAN","tr|S4R341|S4R341_HUMAN",5305,"S4R341","S4R341_HUMAN",null,null,"NOLC1"]
["22.5828","22.5393","22.7488","23.2126",{"$nulls":3},"cholesterol biosynthetic process;dimethylallyl diphosphate biosynthetic process;isopentenyl diphosphate biosynthetic process;isoprenoid biosynthetic process;regulation of cholesterol biosynthetic process","hydrolase activity;isopentenyl-diphosphate delta-isomerase activity;magnesium ion binding;manganese ion binding;metal ion binding","cytosol;peroxisome","Metabolic pathways;Terpenoid backbone biosynthesis",null,null,5,5,5,"27.8","27.8","27.8","26.319",0,"51.134",869730000,33,"0.670785",1,"-0.419659","-1.80154","sp|Q13907|IDI1_HUMAN;tr|C9JKM8|C9JKM8_HUMAN;tr|C9JD53|C9JD53_HUMAN","sp|Q13907|IDI1_HUMAN",2317,"Q13907","IDI1_HUMAN","Isopentenyl-diphosphate Delta-isomerase 1",null,"IDI1"]
[1,"17.1621","18.0025",1,{"$nulls":9},2,2,2,"9.9","9.9","9.9","35.248","0.0037106","3.0468",37739000,3,"0.0111389",1,"-0.420169","-0.0358224","sp|Q8N5C7|DTWD1_HUMAN;tr|H0YML0|H0YML0_HUMAN","sp|Q8N5C7|DTWD1_HUMAN;tr|H0YML0|H0YML0_HUMAN",3237,"Q8N5C7","DTWD1_HUMAN","DTW domain-containing protein 1",null,"DTWD1"]
["18.2315","16.9896","18.4431","17.6212",{"$nulls":3},"CUT catabolic process;dosage compensation by inactivation of X chromosome;histone mRNA catabolic process;maturation of 5.8S rRNA;negative regulation of telomere maintenance via telomerase;nuclear mRNA surveillance;nuclear polyadenylation-dependent rRNA catabolic process;nuclear retention of unspliced pre-mRNA at the site of transcription;nuclear-transcribed mRNA catabolic process;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;regulation of telomerase RNA localization to Cajal body;rRNA processing","3'-5'-exoribonuclease activity;exoribonuclease activity;nucleotide binding;RNA binding;telomerase RNA binding","cytoplasm;cytosol;exosome (RNase complex);membrane;nuclear exosome (RNase complex);nucleolus;nucleoplasm;nucleus;transcriptionally active chromatin","RNA degradation",null,null,10,10,10,"13.7","13.7","13.7","100.83",0,"21.346",146690000,25,"0.201806",1,"-0.421586","-0.566163","sp|Q01780|EXOSX_HUMAN;tr|K7EJ37|K7EJ37_HUMAN","sp|Q01780|EXOSX_HUMAN",2053,"Q01780","EXOSX_HUMAN","Exosome component 10",null,"EXOSC10"]
["22.1081","22.6041","22.8313","22.7331",{"$nulls":3},"carbohydrate metabolic process;tricarboxylic acid cycle","isocitrate dehydrogenase (NAD+) activity;magnesium ion binding;NAD binding","mitochondrial matrix;mitochondrion;myelin sheath;nucleus","2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids;Carbon metabolism;Citrate cycle (TCA cycle);Metabolic pathways",null,null,10,10,3,"31.4","31.4","9.6","39.591",0,"59.986",1009700000,64,"0.630822",1,"-0.42613","-1.68527","sp|P50213|IDH3A_HUMAN;tr|H0YL72|H0YL72_HUMAN;tr|H0YLI6|H0YLI6_HUMAN;tr|H0YKD0|H0YKD0_HUMAN;tr|H0YM64|H0YM64_HUMAN;tr|H0YNF5|H0YNF5_HUMAN;tr|H0YM46|H0YM46_HUMAN","sp|P50213|IDH3A_HUMAN;tr|H0YL72|H0YL72_HUMAN;tr|H0YLI6|H0YLI6_HUMAN;tr|H0YKD0|H0YKD0_HUMAN",1618,"P50213","IDH3A_HUMAN","Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial",null,"IDH3A"]
["22.0312","21.3205","22.2282","21.9783",{"$nulls":3},"brain development;endoplasmic reticulum tubular network organization;eye development;lipid particle organization;neutrophil degranulation;nuclear import;protein transport;small GTPase mediated signal transduction","GDP binding;GTP binding;GTPase activity","cytosol;endoplasmic reticulum membrane;endoplasmic reticulum tubular network;extracellular exosome;Golgi apparatus;intracellular;plasma membrane;secretory granule membrane",{"$nulls":3},6,6,6,"36.4","36.4","36.4","22.977",0,"56.06",498800000,31,"0.426864",1,"-0.427383","-1.13457","sp|Q9NP72|RAB18_HUMAN;tr|A0A087X163|A0A087X163_HUMAN;tr|Q5W0J0|Q5W0J0_HUMAN;tr|H0Y6T8|H0Y6T8_HUMAN","sp|Q9NP72|RAB18_HUMAN;tr|A0A087X163|A0A087X163_HUMAN;tr|Q5W0J0|Q5W0J0_HUMAN;tr|H0Y6T8|H0Y6T8_HUMAN",4353,"Q9NP72","RAB18_HUMAN","Ras-related protein Rab-18",null,"RAB18"]
["24.2909","23.6499","24.6955","24.1052",{"$nulls":3},"aerobic respiration;mitochondrial electron transport, ubiquinol to cytochrome c;oxidation-reduction process;oxidative phosphorylation;protein processing;response to activity;response to alkaloid","metalloendopeptidase activity;protein complex binding;ubiquinol-cytochrome-c reductase activity;ubiquitin protein ligase binding;zinc ion binding","cytosol;mitochondrial inner membrane;mitochondrial respiratory chain;mitochondrial respiratory chain complex III;mitochondrion;myelin sheath","Alzheimer disease;Cardiac muscle contraction;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,19,19,18,"52.9","52.9","51.5","52.645",0,"311.45",4032300000,179,"0.368745",1,"-0.429931","-0.986672","sp|P31930|QCR1_HUMAN","sp|P31930|QCR1_HUMAN",1335,"P31930","QCR1_HUMAN","Cytochrome b-c1 complex subunit 1, mitochondrial",null,"UQCRC1"]
["17.5443","18.2806","18.2867","18.4172",{"$nulls":3},"7-methylguanosine mRNA capping;cell cycle;chromatin remodeling;DNA-templated transcription, elongation;negative regulation of DNA-templated transcription, elongation;negative regulation of mRNA polyadenylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of DNA-templated transcription, elongation;positive regulation of macroautophagy;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral transcription;response to organic substance;single stranded viral RNA replication via double stranded DNA intermediate;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","chromatin binding;DNA binding;enzyme binding;mRNA binding;protein heterodimerization activity;RNA binding","DSIF complex;nucleoplasm;nucleus",{"$nulls":3},9,9,9,"14.9","14.9","14.9",121,0,"31.796",152650000,27,"0.442702",1,"-0.439436","-1.17536","sp|O00267|SPT5H_HUMAN;tr|M0QYL9|M0QYL9_HUMAN","sp|O00267|SPT5H_HUMAN",208,"O00267","SPT5H_HUMAN","Transcription elongation factor SPT5","SPT5","SUPT5H"]
["22.9638","21.8843","23.0995","22.6292",{"$nulls":3},"cell cycle;cellular response to DNA damage stimulus;formation of translation preinitiation complex;IRES-dependent viral translational initiation;positive regulation of cell proliferation;regulation of growth;regulation of transcription, DNA-templated;ribosome disassembly;transcription, DNA-templated;translation reinitiation","translation initiation factor activity","cytosol;plasma membrane",{"$nulls":3},7,7,7,"52.5","52.5","52.5","20.555",0,"53.625",615580000,44,"0.273635",1,"-0.440292","-0.747794","sp|Q9ULC4|MCTS1_HUMAN","sp|Q9ULC4|MCTS1_HUMAN",4808,"Q9ULC4","MCTS1_HUMAN","Malignant T-cell-amplified sequence 1","CT-1","MCTS1"]
["15.4075",1,1,"16.2894",{"$nulls":9},3,3,3,"8.1","8.1","8.1","54.231","0.00067674","4.2891",20075000,3,"0.0130796",1,"-0.440909","-0.0419751","sp|Q86SX3|CN080_HUMAN;tr|C9J6B2|C9J6B2_HUMAN;tr|C9K0G6|C9K0G6_HUMAN;tr|C9IYA4|C9IYA4_HUMAN;tr|C9J317|C9J317_HUMAN;tr|F8VP51|F8VP51_HUMAN","sp|Q86SX3|CN080_HUMAN;tr|C9J6B2|C9J6B2_HUMAN;tr|C9K0G6|C9K0G6_HUMAN;tr|C9IYA4|C9IYA4_HUMAN",3029,"Q86SX3","CN080_HUMAN","Uncharacterized protein C14orf80",null,"C14orf80"]
["20.6462","20.6201","21.947","20.2048",{"$nulls":3},"mRNA splicing, via spliceosome","nucleic acid binding","nucleoplasm",{"$nulls":3},9,9,9,"30.5","30.5","30.5","52.228",0,"73.269",691280000,49,"0.179259",1,"-0.442743","-0.508198","sp|Q92917|GPKOW_HUMAN","sp|Q92917|GPKOW_HUMAN",3552,"Q92917","GPKOW_HUMAN","G-patch domain and KOW motifs-containing protein",null,"GPKOW"]
["20.825","20.8181","21.1469","21.3884",{"$nulls":3},"carbohydrate metabolic process;pentose-phosphate shunt;pentose-phosphate shunt, oxidative branch","6-phosphogluconolactonase activity","cytoplasm;cytosol;extracellular exosome","Carbon metabolism;Metabolic pathways;Pentose phosphate pathway",null,null,5,5,5,"35.7","35.7","35.7","27.547",0,"31.099",221470000,11,"1.17978",1,"-0.446112","-3.69394","sp|O95336|6PGL_HUMAN;tr|M0R261|M0R261_HUMAN;tr|M0R0U3|M0R0U3_HUMAN;tr|M0R1L2|M0R1L2_HUMAN","sp|O95336|6PGL_HUMAN;tr|M0R261|M0R261_HUMAN",716,"O95336","6PGL_HUMAN","6-phosphogluconolactonase","PGL","PGLS"]
["18.5687","18.5252","19.0054","18.9862",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;cell-cell signaling;female pregnancy;membrane organization;peptide catabolic process;protein catabolic process;protein polyubiquitination;proteolysis;regulation of blood pressure;signal transduction;SMAD protein signal transduction","aminopeptidase activity;metalloaminopeptidase activity;metallopeptidase activity;peptide binding;zinc ion binding","cytoplasmic vesicle membrane;cytosol;early endosome lumen;extracellular region;integral component of plasma membrane;intracellular;lysosomal membrane;membrane;perinuclear region of cytoplasm;plasma membrane","Renin-angiotensin system",null,null,11,11,11,"14.4","14.4","14.4","117.35",0,"37.923",197130000,24,"2.55414",1,"-0.448897","-18.8869","sp|Q9UIQ6|LCAP_HUMAN","sp|Q9UIQ6|LCAP_HUMAN",4758,"Q9UIQ6","LCAP_HUMAN","Leucyl-cystinyl aminopeptidase","ystinyl aminopeptidase","LNPEP"]
["23.269","22.5713","23.4705","23.2728",{"$nulls":3},"adenine salvage;central nervous system neuron development;cerebral cortex neuron differentiation;cytolysis;dendrite morphogenesis;dopamine metabolic process;GMP catabolic process;grooming behavior;guanine salvage;hypoxanthine metabolic process;hypoxanthine salvage;IMP metabolic process;IMP salvage;locomotory behavior;lymphocyte proliferation;positive regulation of dopamine metabolic process;protein homotetramerization;purine nucleotide biosynthetic process;purine ribonucleoside salvage;purine-containing compound salvage;response to amphetamine;striatum development","guanine phosphoribosyltransferase activity;hypoxanthine phosphoribosyltransferase activity;identical protein binding;magnesium ion binding;nucleotide binding;protein homodimerization activity","cytoplasm;cytosol;extracellular exosome","Drug metabolism - other enzymes;Metabolic pathways;Purine metabolism",null,null,10,10,10,56,56,56,"24.579",0,"50.156",1077700000,53,"0.469631",1,"-0.451509","-1.24531","sp|P00492|HPRT_HUMAN","sp|P00492|HPRT_HUMAN",803,"P00492","HPRT_HUMAN","Hypoxanthine-guanine phosphoribosyltransferase","GPRT;GPRTase","HPRT1"]
["23.2542","24.027","23.8565","24.3381",{"$nulls":9},2,2,2,"15.6","15.6","15.6","7.0662","0.0037259","3.1051",376400000,16,"0.37527",1,"-0.456713","-1.00316","sp|Q9Y2S6|TMA7_HUMAN","sp|Q9Y2S6|TMA7_HUMAN",4934,"Q9Y2S6","TMA7_HUMAN","Translation machinery-associated protein 7",null,"TMA7"]
["17.2881",1,"18.2029",1,{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding;zinc ion binding","catalytic step 2 spliceosome;nuclear body;nucleoplasm;nucleus",{"$nulls":3},5,5,5,"10.5","10.5","10.5","78.576",0,"11.525",50017000,8,"0.0120183",1,"-0.457389","-0.0386137","sp|Q6NZY4|ZCHC8_HUMAN;tr|F5H6J5|F5H6J5_HUMAN;tr|F5GX80|F5GX80_HUMAN;tr|F5GXQ6|F5GXQ6_HUMAN;tr|F5H803|F5H803_HUMAN","sp|Q6NZY4|ZCHC8_HUMAN;tr|F5H6J5|F5H6J5_HUMAN;tr|F5GX80|F5GX80_HUMAN;tr|F5GXQ6|F5GXQ6_HUMAN",2844,"Q6NZY4","ZCHC8_HUMAN","Zinc finger CCHC domain-containing protein 8",null,"ZCCHC8"]
["21.8531","21.5057","22.9057","21.3765",{"$nulls":9},9,9,0,"52.4","52.4",0,"27.468",0,"45.771",442310000,44,"0.210692",1,"-0.461703","-0.588844","tr|F5H0B0|F5H0B0_HUMAN;tr|H0YC42|H0YC42_HUMAN;tr|E5RFR7|E5RFR7_HUMAN;tr|H0YC44|H0YC44_HUMAN;tr|U3KQQ8|U3KQQ8_HUMAN","tr|F5H0B0|F5H0B0_HUMAN;tr|H0YC42|H0YC42_HUMAN",5224,"F5H0B0"]
["22.0472","21.3013","22.3066","21.9671",{"$nulls":3},"cell differentiation;multicellular organism development;production of siRNA involved in RNA interference;spermatogenesis","DNA binding;metal ion binding;protein transporter activity;RNA binding;sequence-specific DNA binding","cytosol;Golgi apparatus;nucleus;perinuclear region of cytoplasm",{"$nulls":3},9,9,9,"45.9","45.9","45.9","33.112",0,"50.538",656570000,54,"0.424678",1,"-0.462592","-1.12896","sp|Q99598|TSNAX_HUMAN;tr|C4P0D6|C4P0D6_HUMAN;tr|C4P0D8|C4P0D8_HUMAN;tr|C4P0D4|C4P0D4_HUMAN;tr|Q5VVQ1|Q5VVQ1_HUMAN;tr|Q9NRI2|Q9NRI2_HUMAN","sp|Q99598|TSNAX_HUMAN;tr|C4P0D6|C4P0D6_HUMAN;tr|C4P0D8|C4P0D8_HUMAN;tr|C4P0D4|C4P0D4_HUMAN;tr|Q5VVQ1|Q5VVQ1_HUMAN",3863,"Q99598","TSNAX_HUMAN","Translin-associated protein X",null,"TSNAX"]
["18.8698","19.4275","19.3601","19.8695",{"$nulls":3},"post-translational protein modification","transcription factor binding;ubiquitin binding;ubiquitin protein ligase binding","cytosol;nuclear body;nucleoplasm;VCP-NPL4-UFD1 AAA ATPase complex",{"$nulls":3},7,7,7,"21.5","21.5","21.5","54.862",0,"45.258",127130000,18,"0.465399",1,"-0.466115","-1.23426","sp|O94888|UBXN7_HUMAN;tr|C9JAT7|C9JAT7_HUMAN;tr|F8WB69|F8WB69_HUMAN;tr|C9JD50|C9JD50_HUMAN;tr|H7BYF4|H7BYF4_HUMAN","sp|O94888|UBXN7_HUMAN;tr|C9JAT7|C9JAT7_HUMAN",666,"O94888","UBXN7_HUMAN","UBX domain-containing protein 7",null,"UBXN7"]
["16.36","16.0601","16.6157","16.7424",{"$nulls":3},"cell cycle;cell division;chromosome condensation;inner cell mass cell proliferation","methylated histone binding","condensin complex;membrane;nuclear speck;nucleoplasm",{"$nulls":3},18,18,18,"23.4","23.4","23.4","130.96",0,"72.927",656430000,94,"0.990141",1,"-0.468983","-2.8814","sp|Q86XI2|CNDG2_HUMAN;tr|H0Y6U5|H0Y6U5_HUMAN;tr|F8WE06|F8WE06_HUMAN","sp|Q86XI2|CNDG2_HUMAN;tr|H0Y6U5|H0Y6U5_HUMAN",3081,"Q86XI2","CNDG2_HUMAN","Condensin-2 complex subunit G2",null,"NCAPG2"]
["23.2483","22.6632","23.3875","23.465",{"$nulls":3},"calcium ion import into sarcoplasmic reticulum;calcium ion transmembrane transport;calcium ion transport from cytosol to endoplasmic reticulum;cardiac muscle hypertrophy in response to stress;cell adhesion;cellular calcium ion homeostasis;cellular response to oxidative stress;endoplasmic reticulum calcium ion homeostasis;epidermis development;ER-nucleus signaling pathway;ion transmembrane transport;negative regulation of heart contraction;organelle organization;positive regulation of endoplasmic reticulum calcium ion concentration;positive regulation of heart rate;regulation of calcium ion-dependent exocytosis of neurotransmitter;regulation of cardiac conduction;regulation of cardiac muscle cell action potential involved in regulation of contraction;regulation of cardiac muscle cell membrane potential;regulation of cardiac muscle contraction by calcium ion signaling;regulation of the force of heart contraction;relaxation of cardiac muscle;response to endoplasmic reticulum stress;sarcoplasmic reticulum calcium ion transport;transition between fast and slow fiber;T-tubule organization","ATP binding;calcium ion binding;calcium-transporting ATPase activity;calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential;enzyme binding;lutropin-choriogonadotropic hormone receptor binding;protein C-terminus binding;S100 protein binding","calcium ion-transporting ATPase complex;endoplasmic reticulum;endoplasmic reticulum membrane;extrinsic component of cytoplasmic side of plasma membrane;integral component of plasma membrane;longitudinal sarcoplasmic reticulum;membrane;nucleoplasm;perinuclear region of cytoplasm;platelet dense tubular network membrane;protein complex;ribbon synapse;sarcoplasmic reticulum;sarcoplasmic reticulum membrane;vesicle membrane","Adrenergic signaling in cardiomyocytes;Alzheimer disease;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Calcium signaling pathway;cAMP signaling pathway;Cardiac muscle contraction;cGMP-PKG signaling pathway;Dilated cardiomyopathy (DCM);Hypertrophic cardiomyopathy (HCM);Pancreatic secretion;Thyroid hormone signaling pathway",null,null,31,31,31,"35.3","35.3","35.3","114.76",0,"323.31",4970300000,285,"0.598748",1,"-0.470503","-1.59426","sp|P16615|AT2A2_HUMAN;tr|H7C5W9|H7C5W9_HUMAN;sp|O14983|AT2A1_HUMAN;sp|Q93084|AT2A3_HUMAN;tr|H3BVB2|H3BVB2_HUMAN;tr|A0A0C4DH86|A0A0C4DH86_HUMAN;tr|J3QSY6|J3QSY6_HUMAN;tr|H3BTW4|H3BTW4_HUMAN","sp|P16615|AT2A2_HUMAN;tr|H7C5W9|H7C5W9_HUMAN",1086,"P16615","AT2A2_HUMAN","Sarcoplasmic/endoplasmic reticulum calcium ATPase 2","ERCA2;R Ca(2+)-ATPase 2","ATP2A2"]
["18.7907","18.7587","18.9726","19.5245",{"$nulls":3},"branching involved in labyrinthine layer morphogenesis;cellular response to BMP stimulus;extracellular matrix organization;negative regulation of neural precursor cell proliferation;neural tube closure;placenta blood vessel development;positive regulation of glial cell differentiation","serine-type endopeptidase inhibitor activity","extracellular exosome;extracellular region;extracellular space;membrane;plasma membrane","Prostate cancer;Transcriptional misregulation in cancer",null,null,11,11,8,21,21,"15.3","58.397",0,"19.495",167980000,20,"0.640824",1,"-0.473809","-1.71406","sp|O43278|SPIT1_HUMAN;tr|H3BVD9|H3BVD9_HUMAN;tr|H3BTQ8|H3BTQ8_HUMAN;tr|H3BSM2|H3BSM2_HUMAN;tr|H3BNW5|H3BNW5_HUMAN;tr|H3BMB6|H3BMB6_HUMAN","sp|O43278|SPIT1_HUMAN;tr|H3BVD9|H3BVD9_HUMAN;tr|H3BTQ8|H3BTQ8_HUMAN;tr|H3BSM2|H3BSM2_HUMAN",385,"O43278","SPIT1_HUMAN","Kunitz-type protease inhibitor 1",null,"SPINT1"]
["22.3726","20.9008","22.1984","22.0261",{"$nulls":3},"apoptotic process;cell cycle;cerebral cortex development;liver regeneration;macroautophagy;phosphatidylcholine biosynthetic process;positive regulation of protein targeting to mitochondrion;protein folding;regulation of autophagy of mitochondrion;regulation of chromosome separation;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;spermatogenesis;transcription, DNA-templated;Wnt signaling pathway","ATP binding;protein N-terminus binding;protein serine/threonine kinase activity","acrosomal vesicle;chromatin;cytosol;nucleoplasm;nucleus;plasma membrane","Adherens junction;Measles;Mitophagy - animal;NF-kappa B signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Ribosome biogenesis in eukaryotes;Wnt signaling pathway",null,null,15,15,15,58,58,58,"41.213",0,"283.26",5091800000,242,"0.231565",1,"-0.475547","-0.641833","sp|P19784|CSK22_HUMAN;tr|H3BSA1|H3BSA1_HUMAN;tr|H3BV19|H3BV19_HUMAN;tr|H3BNI9|H3BNI9_HUMAN","sp|P19784|CSK22_HUMAN;tr|H3BSA1|H3BSA1_HUMAN;tr|H3BV19|H3BV19_HUMAN",1139,"P19784","CSK22_HUMAN","Casein kinase II subunit alpha'","K II alpha'","CSNK2A2"]
["18.7616","18.6539","19.4549","18.9194",{"$nulls":3},"intracellular signal transduction","metal ion binding","intracellular",{"$nulls":3},3,3,3,"18.8","18.8","18.8","35.487",0,"8.6801",76542000,9,"0.65511",1,"-0.479412","-1.75553","tr|J3KRN5|J3KRN5_HUMAN;sp|P17252|KPCA_HUMAN","tr|J3KRN5|J3KRN5_HUMAN;sp|P17252|KPCA_HUMAN",1097,"J3KRN5","J3KRN5_HUMAN",null,null,"PRKCA"]
["23.2487","23.0941","23.5176","23.7963",{"$nulls":3},"mitochondrion organization;positive regulation of transcription from RNA polymerase II promoter;regulation of cellular response to hypoxia;transcription, DNA-templated","sequence-specific DNA binding;transcription factor binding","mitochondrial intermembrane space;mitochondrion;nucleus",{"$nulls":3},4,4,4,"33.8","33.8","33.8","15.512",0,"56.009",432720000,35,"1.03183",1,"-0.485572","-3.0471","sp|Q9Y6H1|CHCH2_HUMAN;sp|Q5T1J5|CHCH9_HUMAN","sp|Q9Y6H1|CHCH2_HUMAN;sp|Q5T1J5|CHCH9_HUMAN",5095,"Q9Y6H1","CHCH2_HUMAN","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2",null,"CHCHD2"]
["19.7974","19.4298","20.1837","20.0148",{"$nulls":3},"cell cycle arrest;cellular response to DNA damage stimulus;DNA damage response, detection of DNA damage;G1/S transition of mitotic cell cycle;global genome nucleotide-excision repair;hemopoiesis;in utero embryonic development;intrinsic apoptotic signaling pathway;negative regulation of cell proliferation;negative regulation of granulocyte differentiation;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 3'-to lesion;nucleotide-excision repair, DNA incision, 5'-to lesion;nucleotide-excision repair, preincision complex assembly;nucleotide-excision repair, preincision complex stabilization;positive regulation of cell proliferation;positive regulation of G1/S transition of mitotic cell cycle;post-translational protein modification;proteasome-mediated ubiquitin-dependent protein catabolic process;protein ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of DNA damage checkpoint;regulation of nucleotide-excision repair;regulation of protein metabolic process;somatic stem cell population maintenance;transcription-coupled nucleotide-excision repair;viral process","ubiquitin protein ligase binding","Cul4A-RING E3 ubiquitin ligase complex;Cul4-RING E3 ubiquitin ligase complex;nucleoplasm","Human immunodeficiency virus 1 infection;Nucleotide excision repair;Ubiquitin mediated proteolysis",null,null,13,9,9,20,"14.5","14.5","87.679",0,"33.063",563520000,49,"0.858884",1,"-0.485681","-2.40061","sp|Q13619|CUL4A_HUMAN;tr|A0A0A0MR50|A0A0A0MR50_HUMAN;tr|A0A087WWN2|A0A087WWN2_HUMAN","sp|Q13619|CUL4A_HUMAN;tr|A0A0A0MR50|A0A0A0MR50_HUMAN",2294,"Q13619","CUL4A_HUMAN","Cullin-4A","UL-4A","CUL4A"]
["22.419","22.8787","23.7437","22.5326",{"$nulls":4},"actin binding;structural molecule activity","cell junction;cytoskeleton;nucleus;plasma membrane",{"$nulls":3},40,40,38,"51.4","51.4","49.9","104.36",0,"323.31",4093500000,329,"0.276689",1,"-0.489305","-0.755458","tr|E9PHY5|E9PHY5_HUMAN;sp|O43491|E41L2_HUMAN;tr|E9PK52|E9PK52_HUMAN;tr|E9PII3|E9PII3_HUMAN;tr|I6L9B1|I6L9B1_HUMAN;tr|E9PQD2|E9PQD2_HUMAN;tr|E9PQN0|E9PQN0_HUMAN;tr|E9PRG1|E9PRG1_HUMAN;tr|E9PIG0|E9PIG0_HUMAN;tr|Q6R5J7|Q6R5J7_HUMAN;tr|E9PJP4|E9PJP4_HUMAN;tr|H0Y5B0|H0Y5B0_HUMAN;tr|Q6ZSX4|Q6ZSX4_HUMAN;tr|E9PMV8|E9PMV8_HUMAN;tr|E9PPC9|E9PPC9_HUMAN;tr|E9PMG5|E9PMG5_HUMAN;tr|E9PN54|E9PN54_HUMAN","tr|E9PHY5|E9PHY5_HUMAN;sp|O43491|E41L2_HUMAN;tr|E9PK52|E9PK52_HUMAN;tr|E9PII3|E9PII3_HUMAN;tr|I6L9B1|I6L9B1_HUMAN",5213,"E9PHY5","E9PHY5_HUMAN",null,null,"EPB41L2"]
["20.4118","17.8818","18.8794","20.3972",{"$nulls":3},"microtubule bundle formation;microtubule polymerization;positive regulation of protein complex assembly;positive regulation of protein polymerization","microtubule binding;tubulin binding","cytoplasm;cytosol;microtubule;mitochondrion;myelin sheath;nucleus;perinuclear region of cytoplasm",{"$nulls":3},5,5,5,"36.1","36.1","36.1","23.693",0,"21.085",154840000,10,"0.11312",1,"-0.491491","-0.333172","sp|O94811|TPPP_HUMAN","sp|O94811|TPPP_HUMAN",653,"O94811","TPPP_HUMAN","Tubulin polymerization-promoting protein","PPP","TPPP"]
["19.2194","18.6217","19.5504","19.2762",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;attachment of mitotic spindle microtubules to kinetochore;cell division;cell proliferation;establishment or maintenance of microtubule cytoskeleton polarity;metaphase plate congression;microtubule depolymerization;microtubule-based movement;mitotic cell cycle;mitotic metaphase plate congression;regulation of chromosome segregation;retrograde vesicle-mediated transport, Golgi to ER;sister chromatid cohesion","ATP binding;ATPase activity;centromeric DNA binding;microtubule motor activity;microtubule plus-end binding","centrosome;chromosome, centromeric region;condensed chromosome kinetochore;cytosol;kinesin complex;kinetochore;membrane;microtubule cytoskeleton;microtubule plus-end;nucleoplasm",{"$nulls":3},13,12,12,"27.6","26.3","26.3","81.312",0,"44.674",411740000,55,"0.564292",1,"-0.492784","-1.4986","sp|Q99661|KIF2C_HUMAN;tr|Q5JR89|Q5JR89_HUMAN;tr|Q5JR91|Q5JR91_HUMAN;tr|H0Y5Z9|H0Y5Z9_HUMAN;sp|Q8N4N8|KIF2B_HUMAN","sp|Q99661|KIF2C_HUMAN",3873,"Q99661","KIF2C_HUMAN","Kinesin-like protein KIF2C",null,"KIF2C"]
["17.0289","18.2461","18.3169","17.9516",{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,12,12,12,"50.559",0,"13.495",53706000,14,"0.287185",1,"-0.496767","-0.781788","sp|Q7L4I2|RSRC2_HUMAN;tr|E9PI52|E9PI52_HUMAN","sp|Q7L4I2|RSRC2_HUMAN",2967,"Q7L4I2","RSRC2_HUMAN","Arginine/serine-rich coiled-coil protein 2",null,"RSRC2"]
[1,"16.5994",1,"17.5959",{"$nulls":3},"intracellular protein transport","Ran GTPase binding","intracellular",{"$nulls":3},5,1,1,"46.2","13.2","13.2","20.487","0.00067507","4.2328",4833400,1,"0.0136408",1,"-0.498232","-0.0437498","tr|H0Y3V4|H0Y3V4_HUMAN","tr|H0Y3V4|H0Y3V4_HUMAN",5247,"H0Y3V4","H0Y3V4_HUMAN",null,null,"IPO5"]
["17.8866",1,"18.8914",1,{"$nulls":3},"positive regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter","metal ion binding;proximal promoter sequence-specific DNA binding;sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","nucleus",{"$nulls":3},3,1,1,"8.6","4.3","4.3","41.347","0.0065541","2.6045",40506000,23,"0.0127218",1,"-0.502407","-0.0408428","sp|O15391|TYY2_HUMAN","sp|O15391|TYY2_HUMAN",360,"O15391","TYY2_HUMAN","Transcription factor YY2",null,"YY2"]
["16.9732","18.4889","18.547","17.925",{"$nulls":3},"nucleoside triphosphate catabolic process","phosphoric diester hydrolase activity;zinc ion binding","extracellular exosome;extracellular space",{"$nulls":3},3,3,3,"7.7","7.7","7.7","51.26","0.00026645","7.7103",64027000,8,"0.221554",1,"-0.504988","-0.616466","sp|Q92484|ASM3A_HUMAN","sp|Q92484|ASM3A_HUMAN",3478,"Q92484","ASM3A_HUMAN","Acid sphingomyelinase-like phosphodiesterase 3a","SM-like phosphodiesterase 3a","SMPDL3A"]
["20.818","19.7407","21.2742","20.3022",{"$nulls":3},"positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;transcription, DNA-templated","RNA binding;RNA polymerase II proximal promoter sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding","cytoplasm;membrane;nucleus",{"$nulls":3},18,16,16,"51.9",49,49,"61.64",0,"72.762",466270000,58,"0.255157",1,"-0.508827","-0.701355","sp|Q96I24|FUBP3_HUMAN","sp|Q96I24|FUBP3_HUMAN",3727,"Q96I24","FUBP3_HUMAN","Far upstream element-binding protein 3","USE-binding protein 3","FUBP3"]
["21.1453","19.9718","21.1017","21.0332",{"$nulls":3},"cellular response to estrogen stimulus;positive regulation of gene expression, epigenetic","RNA polymerase II transcription coactivator activity","nuclear chromatin",{"$nulls":3},6,6,6,"38.9","38.9","38.9","25.807",0,"14.154",162650000,13,"0.32076",1,"-0.50894","-0.865966","tr|A6NG10|A6NG10_HUMAN;tr|K7EMC9|K7EMC9_HUMAN;sp|Q969T9|WBP2_HUMAN;tr|K7EIJ0|K7EIJ0_HUMAN;tr|B4DFG2|B4DFG2_HUMAN;tr|K7ENL2|K7ENL2_HUMAN;tr|K7EIN1|K7EIN1_HUMAN;tr|K7ESN4|K7ESN4_HUMAN;tr|K7EIK1|K7EIK1_HUMAN","tr|A6NG10|A6NG10_HUMAN;tr|K7EMC9|K7EMC9_HUMAN;sp|Q969T9|WBP2_HUMAN;tr|K7EIJ0|K7EIJ0_HUMAN;tr|B4DFG2|B4DFG2_HUMAN;tr|K7ENL2|K7ENL2_HUMAN;tr|K7EIN1|K7EIN1_HUMAN;tr|K7ESN4|K7ESN4_HUMAN",3584,"A6NG10","A6NG10_HUMAN",null,null,"WBP2"]
["21.3506","20.5415","21.7311","21.1839",{"$nulls":4},"cysteine-type endopeptidase activity",{"$nulls":4},7,7,7,"36.4","36.4","36.4","26.738",0,"19.166",313820000,23,"0.392657",1,"-0.51145","-1.04723","tr|K7ESE8|K7ESE8_HUMAN;tr|J3KSD8|J3KSD8_HUMAN;sp|Q13867|BLMH_HUMAN;tr|K7ES02|K7ES02_HUMAN","tr|K7ESE8|K7ESE8_HUMAN;tr|J3KSD8|J3KSD8_HUMAN;sp|Q13867|BLMH_HUMAN;tr|K7ES02|K7ES02_HUMAN",2309,"K7ESE8","K7ESE8_HUMAN",null,null,"BLMH"]
["19.7878","17.6985","19.9884","18.5262",{"$nulls":3},"Golgi ribbon formation;protein transport",null,"cis-Golgi network;endoplasmic reticulum exit site;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus;integral component of membrane",{"$nulls":3},3,3,3,17,17,17,"26.005","0.00046871","4.9627",68430000,5,"0.139194",1,"-0.514194","-0.403261","sp|Q9Y3A6|TMED5_HUMAN;tr|M0R072|M0R072_HUMAN;tr|B1AKT3|B1AKT3_HUMAN","sp|Q9Y3A6|TMED5_HUMAN",4972,"Q9Y3A6","TMED5_HUMAN","Transmembrane emp24 domain-containing protein 5",null,"TMED5"]
["15.9494",1,"16.9807",1,{"$nulls":3},"ribosomal large subunit assembly","RNA binding;rRNA binding","nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},2,2,2,"6.3","6.3","6.3","53.193",0,"14.32",79242000,8,"0.0147107",1,"-0.515641","-0.047127","sp|Q9NQ55|SSF1_HUMAN;tr|A0A0A6YYI3|A0A0A6YYI3_HUMAN;tr|A0A0B4J1V8|A0A0B4J1V8_HUMAN;tr|H7C446|H7C446_HUMAN;tr|A8MV53|A8MV53_HUMAN","sp|Q9NQ55|SSF1_HUMAN;tr|A0A0A6YYI3|A0A0A6YYI3_HUMAN;tr|A0A0B4J1V8|A0A0B4J1V8_HUMAN;tr|H7C446|H7C446_HUMAN;tr|A8MV53|A8MV53_HUMAN",4380,"Q9NQ55","SSF1_HUMAN","Suppressor of SWI4 1 homolog","sf-1","PPAN"]
[1,"17.0616",1,"18.0971",{"$nulls":4},"RNA binding",{"$nulls":4},2,2,2,"9.6","9.6","9.6","27.354","0.0035358","3.1626",14747000,1,"0.0137647",1,"-0.517735","-0.0441412","sp|Q9H3H3|CK068_HUMAN","sp|Q9H3H3|CK068_HUMAN",4185,"Q9H3H3","CK068_HUMAN","UPF0696 protein C11orf68",null,"C11orf68"]
["19.2624","18.4368","19.3321","19.4082",{"$nulls":3},"adenosine to inosine editing;cellular response to DNA damage stimulus;cellular response to UV;circadian rhythm;endothelial to hematopoietic transition;forebrain radial glial cell differentiation;gliogenesis;mRNA catabolic process;mRNA destabilization;mRNA methylation;mRNA processing;mRNA splicing, via spliceosome;negative regulation of Notch signaling pathway;positive regulation of cap-independent translational initiation;primary miRNA methylation;primary miRNA processing;regulation of hematopoietic stem cell differentiation;regulation of meiotic cell cycle;regulation of T cell differentiation;RNA metabolic process;RNA methylation;spermatogenesis;stem cell population maintenance","mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;mRNA binding;protein heterodimerization activity;RNA methyltransferase activity;S-adenosyl-L-methionine binding","nuclear speck;nucleoplasm;nucleus;RNA N6-methyladenosine methyltransferase complex",{"$nulls":3},7,7,7,"18.6","18.6","18.6","64.473",0,"16.965",154420000,20,"0.473627",1,"-0.520543","-1.25576","sp|Q86U44|MTA70_HUMAN;tr|F5H6D8|F5H6D8_HUMAN;tr|B4DTN4|B4DTN4_HUMAN;tr|H0YFV6|H0YFV6_HUMAN;tr|B4E349|B4E349_HUMAN","sp|Q86U44|MTA70_HUMAN;tr|F5H6D8|F5H6D8_HUMAN;tr|B4DTN4|B4DTN4_HUMAN;tr|H0YFV6|H0YFV6_HUMAN",3042,"Q86U44","MTA70_HUMAN","N6-adenosine-methyltransferase catalytic subunit {ECO:0000305}",null,"METTL3"]
["18.5169","18.6188","18.8694","19.3188",{"$nulls":4},"metal ion binding","cell junction;fibrillar center;focal adhesion",{"$nulls":3},2,2,2,"19.4","19.4","19.4","15.934","0.00023736","5.2619",33111000,8,"0.824543",1,"-0.526282","-2.28405","tr|E7EWE8|E7EWE8_HUMAN;sp|Q8WUP2|FBLI1_HUMAN;tr|D6RAI6|D6RAI6_HUMAN;tr|E7EPI5|E7EPI5_HUMAN;tr|E7EN81|E7EN81_HUMAN","tr|E7EWE8|E7EWE8_HUMAN;sp|Q8WUP2|FBLI1_HUMAN;tr|D6RAI6|D6RAI6_HUMAN;tr|E7EPI5|E7EPI5_HUMAN;tr|E7EN81|E7EN81_HUMAN",3426,"E7EWE8","E7EWE8_HUMAN",null,null,"FBLIM1"]
["21.0566","21.4619","21.6023","21.9778",{"$nulls":3},"asparagine biosynthetic process;cellular amino acid biosynthetic process;cellular response to glucose starvation;cellular response to hormone stimulus;glutamine metabolic process;L-asparagine biosynthetic process;liver development;negative regulation of apoptotic process;PERK-mediated unfolded protein response;positive regulation of mitotic cell cycle;response to amino acid;response to follicle-stimulating hormone;response to light stimulus;response to mechanical stimulus;response to methotrexate;response to toxic substance","asparagine synthase (glutamine-hydrolyzing) activity;ATP binding;cofactor binding;protein homodimerization activity","cytosol","Alanine, aspartate and glutamate metabolism;Biosynthesis of amino acids;Metabolic pathways",null,null,13,13,13,"29.6","29.6","29.6","64.369",0,"74.287",917430000,42,"0.710745",1,"-0.530837","-1.92128","sp|P08243|ASNS_HUMAN;tr|F8WEJ5|F8WEJ5_HUMAN;tr|C9J057|C9J057_HUMAN","sp|P08243|ASNS_HUMAN",920,"P08243","ASNS_HUMAN","Asparagine synthetase [glutamine-hydrolyzing]",null,"ASNS"]
["21.4031","19.7617","21.3787","20.8487",{"$nulls":3},"error-free translesion synthesis;Golgi organization;negative regulation of RIG-I signaling pathway;negative regulation of type I interferon production;retrograde protein transport, ER to cytosol;ubiquitin-dependent ERAD pathway;ubiquitin-dependent protein catabolic process","metal ion binding;ubiquitin binding;ubiquitin protein ligase binding","cytosol;endoplasmic reticulum;nuclear outer membrane-endoplasmic reticulum membrane network;nucleoplasm;nucleus;UFD1-NPL4 complex;VCP-NPL4-UFD1 AAA ATPase complex","Protein processing in endoplasmic reticulum",null,null,11,11,11,"26.8","26.8","26.8","68.119",0,"99.312",403770000,22,"0.221387",1,"-0.531282","-0.616041","sp|Q8TAT6|NPL4_HUMAN;tr|A0A0D9SFI9|A0A0D9SFI9_HUMAN;tr|I3L4U9|I3L4U9_HUMAN;tr|I3L283|I3L283_HUMAN;tr|I3L3I1|I3L3I1_HUMAN","sp|Q8TAT6|NPL4_HUMAN",3361,"Q8TAT6","NPL4_HUMAN","Nuclear protein localization protein 4 homolog","rotein NPL4","NPLOC4"]
["20.4935","20.3971","21.1253","20.8358",{"$nulls":3},"establishment or maintenance of cell polarity;microtubule cytoskeleton organization;protein localization to plasma membrane;response to osmotic stress","receptor binding;structural molecule activity","basolateral plasma membrane;cytosol;microtubule;microtubule associated complex;microtubule cytoskeleton;perinuclear region of cytoplasm",{"$nulls":3},19,19,19,"32.4","32.4","32.4","84.051",0,"44.462",942660000,121,"1.13955",1,"-0.535255","-3.50832","sp|Q14244|MAP7_HUMAN;tr|A0A087WZ40|A0A087WZ40_HUMAN","sp|Q14244|MAP7_HUMAN;tr|A0A087WZ40|A0A087WZ40_HUMAN",2350,"Q14244","MAP7_HUMAN","Ensconsin",null,"MAP7"]
["24.8603","24.3018","25.1221","25.1166",{"$nulls":4},"cadherin binding;RNA binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;mitochondrial nucleoid;nuclear envelope;organelle membrane",{"$nulls":3},17,17,17,"54.1","54.1","54.1","34.93",0,"323.31",28984000000,556,"0.712864",1,"-0.538318","-1.92773","sp|Q96AG4|LRC59_HUMAN;tr|I3L223|I3L223_HUMAN","sp|Q96AG4|LRC59_HUMAN",3601,"Q96AG4","LRC59_HUMAN","Leucine-rich repeat-containing protein 59",null,"LRRC59"]
["22.8204","21.9456","23.1641","22.6809",{"$nulls":3},"cornification;extracellular matrix disassembly;positive regulation of cell proliferation;regulation of macroautophagy","calcium ion binding;calcium-dependent cysteine-type endopeptidase activity;endopeptidase activity","cytosol;extracellular exosome;membrane;plasma membrane",{"$nulls":3},8,8,8,"36.9","36.9","36.9","28.315",0,"74.377",712790000,45,"0.405444",1,"-0.539516","-1.07977","sp|P04632|CPNS1_HUMAN;tr|A0A0C4DGQ5|A0A0C4DGQ5_HUMAN;tr|K7EIV0|K7EIV0_HUMAN;tr|A0A075B7C0|A0A075B7C0_HUMAN;tr|K7ELJ7|K7ELJ7_HUMAN;tr|U3KQE2|U3KQE2_HUMAN;tr|K7EM73|K7EM73_HUMAN;tr|K7EKD8|K7EKD8_HUMAN;tr|U3KPR7|U3KPR7_HUMAN;sp|Q96L46|CPNS2_HUMAN;tr|K7ES78|K7ES78_HUMAN;tr|K7EMQ1|K7EMQ1_HUMAN","sp|P04632|CPNS1_HUMAN;tr|A0A0C4DGQ5|A0A0C4DGQ5_HUMAN;tr|K7EIV0|K7EIV0_HUMAN;tr|A0A075B7C0|A0A075B7C0_HUMAN;tr|K7ELJ7|K7ELJ7_HUMAN;tr|U3KQE2|U3KQE2_HUMAN;tr|K7EM73|K7EM73_HUMAN;tr|K7EKD8|K7EKD8_HUMAN",844,"P04632","CPNS1_HUMAN","Calpain small subunit 1","SS1","CAPNS1"]
["20.3015","18.9976","20.4112","19.9721",{"$nulls":3},"GTP metabolic process;mature ribosome assembly","GTP binding;GTPase activity;ribosome binding;translation elongation factor activity",null,"Ribosome biogenesis in eukaryotes",null,null,12,12,12,"16.3","16.3","16.3","125.43",0,"79.35",459960000,37,"0.289671",1,"-0.542089","-0.788019","sp|Q7Z2Z2|ETUD1_HUMAN","sp|Q7Z2Z2|ETUD1_HUMAN",2988,"Q7Z2Z2","EFL1_HUMAN","Elongation factor-like GTPase 1",null,"EFL1"]
["16.781","17.7384","17.378","18.2375",{"$nulls":3},"axonogenesis;bicellular tight junction assembly;cell cycle;cell division;cell-cell junction assembly;establishment or maintenance of cell polarity;protein complex assembly;regulation of cell migration",null,"apical plasma membrane;bicellular tight junction;cell cortex;cytosol;extracellular exosome;nucleus;plasma membrane;protein complex","Axon guidance;Endocytosis;Hippo signaling pathway;Human papillomavirus infection;Rap1 signaling pathway;Tight junction",null,null,3,3,3,"10.8","10.8","10.8","41.182","0.0081696","2.3591",20998000,2,"0.31516",1,"-0.548065","-0.851921","sp|Q9BYG5|PAR6B_HUMAN","sp|Q9BYG5|PAR6B_HUMAN",4064,"Q9BYG5","PAR6B_HUMAN","Partitioning defective 6 homolog beta","AR-6 beta;AR-6B","PARD6B"]
[1,"18.1762",1,"19.2806",{"$nulls":3},"ATP hydrolysis coupled proton transport","hydrogen ion transmembrane transporter activity","proton-transporting V-type ATPase, V0 domain",{"$nulls":3},2,2,2,"9.9","9.9","9.9","26.705","0.00067904","4.3288",35371000,2,"0.0137287",1,"-0.552191","-0.0440275","tr|J3QL14|J3QL14_HUMAN;tr|R4GN72|R4GN72_HUMAN;sp|P61421|VA0D1_HUMAN;tr|F5GYQ1|F5GYQ1_HUMAN","tr|J3QL14|J3QL14_HUMAN;tr|R4GN72|R4GN72_HUMAN;sp|P61421|VA0D1_HUMAN;tr|F5GYQ1|F5GYQ1_HUMAN",1846,"J3QL14","J3QL14_HUMAN",null,null,"ATP6V0D1"]
["14.9929","15.5282","15.3681","16.2683",{"$nulls":3},"apoptotic process;mitotic cytokinesis;negative regulation of microtubule depolymerization;positive regulation of transcription from RNA polymerase II promoter",null,"centrosome;cytoplasmic microtubule;cytosol;microtubule cytoskeleton;spindle pole",{"$nulls":3},8,8,8,"15.7","15.7","15.7","76.986",0,"26.94",192160000,35,"0.399599",1,"-0.557647","-1.06488","sp|Q8WWK9|CKAP2_HUMAN;tr|C9J7Y4|C9J7Y4_HUMAN;tr|C9J649|C9J649_HUMAN","sp|Q8WWK9|CKAP2_HUMAN",3455,"Q8WWK9","CKAP2_HUMAN","Cytoskeleton-associated protein 2",null,"CKAP2"]
["22.5341","21.4574","22.4898","22.6193",{"$nulls":3},"DNA repair;DNA replication;regulation of signal transduction by p53 class mediator;regulation of transcription, DNA-templated;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter","chromatin binding;DNA binding;RNA binding","chromosome;nucleolus;nucleoplasm",{"$nulls":3},26,26,26,"46.3","46.3","46.3","81.074",0,"323.31",5074500000,352,"0.386086",1,"-0.558788","-1.03055","sp|Q08945|SSRP1_HUMAN;tr|E9PMD4|E9PMD4_HUMAN;tr|E9PPZ7|E9PPZ7_HUMAN","sp|Q08945|SSRP1_HUMAN",2136,"Q08945","SSRP1_HUMAN","FACT complex subunit SSRP1",null,"SSRP1"]
["15.085",1,"16.2096",1,{"$nulls":3},"signal transduction","ATP binding;G-protein coupled receptor kinase activity",{"$nulls":4},6,6,6,"14.2","14.2","14.2","62.192",0,"17.149",115860000,22,"0.0169752",1,"-0.562297","-0.0542506","tr|F8W9W2|F8W9W2_HUMAN;sp|P43250|GRK6_HUMAN;tr|D6RHX8|D6RHX8_HUMAN;tr|D6RDA3|D6RDA3_HUMAN;tr|D6RHC7|D6RHC7_HUMAN;sp|P34947|GRK5_HUMAN","tr|F8W9W2|F8W9W2_HUMAN;sp|P43250|GRK6_HUMAN;tr|D6RHX8|D6RHX8_HUMAN",1488,"F8W9W2","F8W9W2_HUMAN","G protein-coupled receptor kinase {ECO:0000256|RuleBase:RU000308}",null,"GRK6"]
[1,"16.1821","17.3158",1,{"$nulls":9},4,4,4,"20.1","20.1","20.1","40.703","0.00025233","6.5419",23235000,3,"0.0158975",1,"-0.566804","-0.0508646","tr|A0A0G2JQW1|A0A0G2JQW1_HUMAN;tr|A0A0J9YXQ9|A0A0J9YXQ9_HUMAN;tr|Q53QD4|Q53QD4_HUMAN;sp|Q8WVT3|TPC12_HUMAN;tr|H7C373|H7C373_HUMAN;tr|H7C1E5|H7C1E5_HUMAN;tr|H7C0T3|H7C0T3_HUMAN;tr|H7C185|H7C185_HUMAN;tr|H7C2F7|H7C2F7_HUMAN","tr|A0A0G2JQW1|A0A0G2JQW1_HUMAN;tr|A0A0J9YXQ9|A0A0J9YXQ9_HUMAN;tr|Q53QD4|Q53QD4_HUMAN;sp|Q8WVT3|TPC12_HUMAN;tr|H7C373|H7C373_HUMAN;tr|H7C1E5|H7C1E5_HUMAN;tr|H7C0T3|H7C0T3_HUMAN",3445,"A0A0G2JQW1","A0A0G2JQW1_HUMAN",null,null,"TRAPPC12"]
["18.7841","18.1919","18.9111","19.2013",{"$nulls":5},"cytosol",{"$nulls":3},9,9,9,"12.6","12.6","12.6","107.21",0,"21.954",213320000,29,"0.643885",1,"-0.568175","-1.72291","tr|Q5JR04|Q5JR04_HUMAN;sp|Q9HCE1|MOV10_HUMAN","tr|Q5JR04|Q5JR04_HUMAN;sp|Q9HCE1|MOV10_HUMAN",4326,"Q5JR04","Q5JR04_HUMAN"]
["20.7045","20.6361","21.1511","21.3353",{"$nulls":3},"cholesterol biosynthetic process;ergosterol biosynthetic process;farnesyl diphosphate metabolic process;isoprenoid biosynthetic process;regulation of cholesterol biosynthetic process;regulation of lipid metabolic process;steroid biosynthetic process","farnesyl-diphosphate farnesyltransferase activity;oxidoreductase activity;squalene synthase activity","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Metabolic pathways;Steroid biosynthesis",null,null,10,10,10,"34.8","34.8","34.8","48.115",0,"46.758",618200000,56,"1.55031",1,"-0.572906","-5.83216","sp|P37268|FDFT_HUMAN;tr|E9PNM1|E9PNM1_HUMAN;tr|E9PS69|E9PS69_HUMAN;tr|E9PJG4|E9PJG4_HUMAN","sp|P37268|FDFT_HUMAN;tr|E9PNM1|E9PNM1_HUMAN",1420,"P37268","FDFT_HUMAN","Squalene synthase","QS;S","FDFT1"]
["20.899","21.4521","22.2092","21.2943",{"$nulls":3},"DNA damage response, detection of DNA damage;DNA replication;DNA strand elongation involved in DNA replication;DNA synthesis involved in DNA repair;error-free translesion synthesis;error-prone translesion synthesis;nucleotide-excision repair, DNA gap filling;nucleotide-excision repair, DNA incision;nucleotide-excision repair, DNA incision, 5'-to lesion;positive regulation of DNA-directed DNA polymerase activity;regulation of signal transduction by p53 class mediator;response to organophosphorus;telomere maintenance via semi-conservative replication;transcription-coupled nucleotide-excision repair;translesion synthesis","DNA clamp loader activity","Ctf18 RFC-like complex;DNA replication factor C complex;nucleoplasm;nucleus","DNA replication;Mismatch repair;Nucleotide excision repair",null,null,12,12,12,"42.1","42.1","42.1","40.556",0,"271.84",2512000000,114,"0.404765",1,"-0.576208","-1.07804","sp|P40938|RFC3_HUMAN;tr|A0A087X270|A0A087X270_HUMAN","sp|P40938|RFC3_HUMAN",1446,"P40938","RFC3_HUMAN","Replication factor C subunit 3",null,"RFC3"]
["14.6422",1,1,"15.7971",{"$nulls":3},"branching morphogenesis of an epithelial tube;cell proliferation;cell surface receptor signaling pathway;endothelial cell morphogenesis;entry of bacterium into host cell;establishment of skin barrier;MAPK cascade;negative regulation of autophagy;negative regulation of guanyl-nucleotide exchange factor activity;negative regulation of hydrogen peroxide-mediated programmed cell death;negative regulation of Rho protein signal transduction;negative regulation of stress fiber assembly;negative regulation of thrombin-activated receptor signaling pathway;positive chemotaxis;positive regulation of endothelial cell chemotaxis;positive regulation of microtubule polymerization;positive regulation of protein kinase B signaling;positive regulation of transcription from RNA polymerase II promoter;semaphorin-plexin signaling pathway;signal transduction","ATP binding;hepatocyte growth factor-activated receptor activity;identical protein binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;protein phosphatase binding;protein tyrosine kinase activity;Ras guanyl-nucleotide exchange factor activity","basal plasma membrane;cell surface;extracellular region;integral component of membrane;integral component of plasma membrane;intracellular;plasma membrane","Adherens junction;Axon guidance;Bacterial invasion of epithelial cells;Central carbon metabolism in cancer;EGFR tyrosine kinase inhibitor resistance;Epithelial cell signaling in Helicobacter pylori infection;Focal adhesion;Gastric cancer;Hepatocellular carcinoma;Malaria;MAPK signaling pathway;Melanoma;MicroRNAs in cancer;Pathways in cancer;PI3K-Akt signaling pathway;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Renal cell carcinoma;Transcriptional misregulation in cancer",null,null,4,4,4,"3.7","3.7","3.7","155.54","0.00067552","4.241",11418000,3,"0.017974",1,"-0.577442","-0.0573821","sp|P08581|MET_HUMAN","sp|P08581|MET_HUMAN",927,"P08581","MET_HUMAN","Hepatocyte growth factor receptor","GF receptor","MET"]
["19.6414","16.5002","19.954","17.3441",{"$nulls":3},"heme biosynthetic process;iron-sulfur cluster assembly","RNA binding;transferase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},3,3,3,"15.7","15.7","15.7","38.155",0,"11.48",52383000,9,"0.0949408",1,"-0.578319","-0.283215","sp|Q5T440|CAF17_HUMAN","sp|Q5T440|CAF17_HUMAN",2725,"Q5T440","CAF17_HUMAN","Putative transferase CAF17, mitochondrial",null,"IBA57"]
["20.2922","18.0834","20.5859","18.956",{"$nulls":3},"exocytosis",null,"exocyst",{"$nulls":3},22,22,22,"43.6","43.6","43.6","78.808",0,"162.08",1426700000,137,"0.147349",1,"-0.583137","-0.424863","tr|A0A0A0MSB8|A0A0A0MSB8_HUMAN;sp|Q9UPT5|EXOC7_HUMAN;tr|A0A0A0MRE1|A0A0A0MRE1_HUMAN;tr|B4DJ07|B4DJ07_HUMAN;tr|C9JKC2|C9JKC2_HUMAN;tr|B5MCY9|B5MCY9_HUMAN;tr|K7ERQ5|K7ERQ5_HUMAN;tr|C9JME6|C9JME6_HUMAN","tr|A0A0A0MSB8|A0A0A0MSB8_HUMAN;sp|Q9UPT5|EXOC7_HUMAN;tr|A0A0A0MRE1|A0A0A0MRE1_HUMAN;tr|B4DJ07|B4DJ07_HUMAN",4870,"A0A0A0MSB8","A0A0A0MSB8_HUMAN",null,null,"EXOC7"]
["21.4865","20.1789","21.8024","21.0322",{"$nulls":3},"apoptotic process;autophagic cell death;autophagy;cellular response to amino acid starvation;cellular response to glucose starvation;membrane fission;positive regulation of autophagosome assembly;positive regulation of autophagy;positive regulation of membrane tubulation;positive regulation of protein oligomerization;positive regulation of protein targeting to mitochondrion;protein localization to vacuolar membrane;protein oligomerization;receptor catabolic process;regulation of cytokinesis;regulation of macroautophagy;regulation of protein stability","cadherin binding;identical protein binding;lipid binding;protein homodimerization activity","autophagosome membrane;cytoplasm;cytoplasmic vesicle;cytosol;extracellular exosome;Golgi membrane;midbody;mitochondrial outer membrane","Autophagy - animal;Endocytosis",null,null,7,7,7,"28.5","28.5","28.5","40.796",0,"79.364",361210000,16,"0.282669",1,"-0.584623","-0.770461","sp|Q9Y371|SHLB1_HUMAN;tr|A0A087WW40|A0A087WW40_HUMAN","sp|Q9Y371|SHLB1_HUMAN;tr|A0A087WW40|A0A087WW40_HUMAN",4963,"Q9Y371","SHLB1_HUMAN","Endophilin-B1",null,"SH3GLB1"]
["20.8418","19.7691","21.1363","20.6503",{"$nulls":4},"nucleotide phosphatase activity, acting on free nucleotides",{"$nulls":4},6,6,6,"38.6","38.6","38.6","25.072",0,"33.824",426630000,49,"0.373378",1,"-0.587891","-0.998379","tr|Q5TDF0|Q5TDF0_HUMAN;sp|Q9BSD7|NTPCR_HUMAN","tr|Q5TDF0|Q5TDF0_HUMAN;sp|Q9BSD7|NTPCR_HUMAN",5297,"Q5TDF0","Q5TDF0_HUMAN",null,null,"NTPCR"]
["19.2182","17.9127","19.5078","18.8077",{"$nulls":3},"intracellular protein transport;intra-Golgi vesicle-mediated transport;membrane fusion;protein complex assembly;protein stabilization","soluble NSF attachment protein activity;syntaxin binding","extracellular exosome;lysosomal membrane;mitochondrion;myelin sheath;SNARE complex",{"$nulls":3},5,5,5,"18.9","18.9","18.9","34.746",0,"23.779",83030000,15,"0.294324",1,"-0.592325","-0.799685","sp|Q99747|SNAG_HUMAN;tr|J3KTJ6|J3KTJ6_HUMAN","sp|Q99747|SNAG_HUMAN",3880,"Q99747","SNAG_HUMAN","Gamma-soluble NSF attachment protein","NAP-gamma","NAPG"]
["19.8349","19.531","20.1797","20.3786",{"$nulls":3},"endoplasmic reticulum organization;endoplasmic reticulum tubular network membrane organization;Golgi organization;protein homooligomerization","GTP binding;GTPase activity;identical protein binding","endoplasmic reticulum;endoplasmic reticulum tubular network membrane;integral component of membrane;membrane",{"$nulls":3},5,5,5,"11.8","11.8","11.8","66.228",0,"46.671",229290000,22,"1.0886",1,"-0.596216","-3.28395","sp|Q8NHH9|ATLA2_HUMAN;tr|B5MCN0|B5MCN0_HUMAN;tr|C9JQQ5|C9JQQ5_HUMAN;tr|H7C3A2|H7C3A2_HUMAN","sp|Q8NHH9|ATLA2_HUMAN;tr|B5MCN0|B5MCN0_HUMAN;tr|C9JQQ5|C9JQQ5_HUMAN",3346,"Q8NHH9","ATLA2_HUMAN","Atlastin-2",null,"ATL2"]
["21.7536","20.3456","21.9781","21.3172",{"$nulls":4},"ATP binding;protein kinase activity","cytosol;nucleolus",{"$nulls":3},13,13,10,"41.7","41.7","33.5","45.835",0,"58.159",571630000,62,"0.282085",1,"-0.59804","-0.768997","tr|B4DR80|B4DR80_HUMAN;sp|Q9Y6E0|STK24_HUMAN;tr|H0Y630|H0Y630_HUMAN;tr|Q5JV98|Q5JV98_HUMAN;tr|Q5JV99|Q5JV99_HUMAN","tr|B4DR80|B4DR80_HUMAN;sp|Q9Y6E0|STK24_HUMAN;tr|H0Y630|H0Y630_HUMAN;tr|Q5JV98|Q5JV98_HUMAN",5175,"B4DR80","B4DR80_HUMAN",null,null,"STK24"]
["20.761","19.6742","20.9664","20.6817",{"$nulls":3},"oxidation-reduction process;regulation of osteoclast differentiation","antioxidant activity","cytoplasm;extracellular exosome",{"$nulls":3},4,4,4,21,21,21,"25.764",0,"11.829",215300000,12,"0.405354",1,"-0.606417","-1.07954","sp|Q9BRX8|F213A_HUMAN","sp|Q9BRX8|F213A_HUMAN",3943,"Q9BRX8","F213A_HUMAN","Redox-regulatory protein FAM213A",null,"FAM213A"]
["24.7394","23.8819","25.0573","24.7808",{"$nulls":5},"integral component of membrane",{"$nulls":3},3,3,3,"10.7","10.7","10.7","17.764",0,"8.1658",1208000000,29,"0.50953",1,"-0.608437","-1.35053","tr|A6NNI4|A6NNI4_HUMAN;tr|G8JLH6|G8JLH6_HUMAN;sp|P21926|CD9_HUMAN;tr|F5GXT1|F5GXT1_HUMAN;tr|A0A087WZG3|A0A087WZG3_HUMAN;tr|A0A087WU13|A0A087WU13_HUMAN","tr|A6NNI4|A6NNI4_HUMAN;tr|G8JLH6|G8JLH6_HUMAN;sp|P21926|CD9_HUMAN",1171,"A6NNI4","A6NNI4_HUMAN","Tetraspanin {ECO:0000256|RuleBase:RU361218}",null,"CD9"]
["18.5321","16.0994","19.2475","16.604",{"$nulls":3},"neutrophil degranulation","ATP binding","ficolin-1-rich granule membrane;mitochondrial inner membrane;mitochondrion;plasma membrane;secretory granule membrane",{"$nulls":3},26,6,3,"41.5","11.7","6.5","72.572",0,"42.784",332760000,38,"0.115495",1,"-0.610055","-0.339626","sp|Q5T9A4|ATD3B_HUMAN","sp|Q5T9A4|ATD3B_HUMAN",2736,"Q5T9A4","ATD3B_HUMAN","ATPase family AAA domain-containing protein 3B",null,"ATAD3B"]
["19.4625","17.5817","18.8715","19.3972",{"$nulls":3},"cellular protein catabolic process;protein K48-linked ubiquitination;protein K63-linked ubiquitination;protein ubiquitination;ubiquitin-dependent protein catabolic process","ATP binding;ubiquitin conjugating enzyme activity;ubiquitin protein ligase activity;ubiquitin protein ligase binding;ubiquitin-protein transferase activity","cytoplasm;cytosol;extracellular exosome","Parkinson disease;Protein processing in endoplasmic reticulum;Ubiquitin mediated proteolysis",null,null,4,4,4,"27.6","27.6","27.6","19.509","0.00026212","7.3585",32712000,6,"0.225719",1,"-0.612232","-0.627029","sp|P62253|UB2G1_HUMAN;tr|I3L0Q0|I3L0Q0_HUMAN;tr|I3L2Q4|I3L2Q4_HUMAN;tr|K7EPR7|K7EPR7_HUMAN;tr|I3L2H7|I3L2H7_HUMAN","sp|P62253|UB2G1_HUMAN;tr|I3L0Q0|I3L0Q0_HUMAN;tr|I3L2Q4|I3L2Q4_HUMAN",1878,"P62253","UB2G1_HUMAN","Ubiquitin-conjugating enzyme E2 G1",null,"UBE2G1"]
["21.3053","21.1122","21.4781","22.1705",{"$nulls":3},"tRNA modification;tRNA-guanine transglycosylation","metal ion binding;protein heterodimerization activity;protein homodimerization activity;queuine tRNA-ribosyltransferase activity","mitochondrial outer membrane;nucleus;protein complex",{"$nulls":3},7,7,7,30,30,30,"44.047",0,"70.041",438690000,27,"0.640308",1,"-0.615531","-1.71257","sp|Q9BXR0|TGT_HUMAN;tr|K7ESP6|K7ESP6_HUMAN;tr|K7EPI1|K7EPI1_HUMAN;tr|K7EJ21|K7EJ21_HUMAN;tr|K7EL95|K7EL95_HUMAN","sp|Q9BXR0|TGT_HUMAN;tr|K7ESP6|K7ESP6_HUMAN",4046,"Q9BXR0","TGT_HUMAN","Queuine tRNA-ribosyltransferase catalytic subunit 1 {ECO:0000255|HAMAP-Rule:MF_03218}",null,"QTRT1"]
["14.896","15.8657","16.0941","15.9027",{"$nulls":9},2,2,2,"3.5","3.5","3.5","99.666","0.00066357","4.0358",24966000,4,"0.471282",1,"-0.617559","-1.24962","tr|A0A087WXZ7|A0A087WXZ7_HUMAN;tr|K7EIX2|K7EIX2_HUMAN;sp|Q6AI08|HEAT6_HUMAN;tr|K7ELR8|K7ELR8_HUMAN","tr|A0A087WXZ7|A0A087WXZ7_HUMAN;tr|K7EIX2|K7EIX2_HUMAN;sp|Q6AI08|HEAT6_HUMAN;tr|K7ELR8|K7ELR8_HUMAN",2800,"A0A087WXZ7","A0A087WXZ7_HUMAN",null,null,"HEATR6"]
["18.3969","20.4979","19.9491","20.182",{"$nulls":4},"GTP binding;GTPase activity","cytoplasm;nucleus",{"$nulls":3},27,27,27,51,51,51,"79.548",0,"303.54",2366200000,208,"0.209115",1,"-0.618149","-0.584826","sp|Q3YEC7|RABL6_HUMAN;tr|B1AMX5|B1AMX5_HUMAN;tr|G3V154|G3V154_HUMAN;tr|F2Z2T0|F2Z2T0_HUMAN;tr|H0Y4Z8|H0Y4Z8_HUMAN;tr|H0Y7H6|H0Y7H6_HUMAN;tr|Q8WYT4|Q8WYT4_HUMAN","sp|Q3YEC7|RABL6_HUMAN",2619,"Q3YEC7","RABL6_HUMAN","Rab-like protein 6",null,"RABL6"]
["14.8389","16.6181","15.6578","17.0476",{"$nulls":3},"negative regulation of phosphatase activity;regulation of ARF protein signal transduction","ARF guanyl-nucleotide exchange factor activity;lipid transporter activity","integral component of membrane;transport vesicle membrane",{"$nulls":3},5,5,5,"3.4","3.4","3.4","240.65",0,"12.128",81867000,17,"0.196645",1,"-0.624209","-0.55295","sp|Q5TH69|BIG3_HUMAN","sp|Q5TH69|BIG3_HUMAN",2746,"Q5TH69","BIG3_HUMAN","Brefeldin A-inhibited guanine nucleotide-exchange protein 3 {ECO:0000305}",null,"ARFGEF3"]
["18.0578","17.267","18.7091","17.8643",{"$nulls":3},"DNA damage checkpoint","ATP binding;protein serine/threonine kinase activity","intracellular membrane-bounded organelle;nucleoplasm",{"$nulls":3},3,3,3,"10.4","10.4","10.4","49.019",0,"8.3546",57892000,6,"0.405139",1,"-0.624295","-1.07899","tr|J3KN87|J3KN87_HUMAN;sp|O14757|CHK1_HUMAN;tr|E7EPP6|E7EPP6_HUMAN;tr|E9PM65|E9PM65_HUMAN;tr|E9PQW7|E9PQW7_HUMAN;tr|E9PJI4|E9PJI4_HUMAN;tr|E9PKQ3|E9PKQ3_HUMAN","tr|J3KN87|J3KN87_HUMAN;sp|O14757|CHK1_HUMAN;tr|E7EPP6|E7EPP6_HUMAN",280,"J3KN87","J3KN87_HUMAN",null,null,"CHEK1"]
[1,"14.8759",1,"16.1272",{"$nulls":3},"transcription, DNA-templated","DNA-directed 5'-3' RNA polymerase activity","nucleoplasm;nucleus",{"$nulls":3},2,2,2,3,3,3,"75.773","0.0015142","3.681",21766000,2,"0.0191164",1,"-0.625634","-0.060956","tr|A0A0C4DH01|A0A0C4DH01_HUMAN;sp|Q9NVU0|RPC5_HUMAN;tr|H3BNJ0|H3BNJ0_HUMAN","tr|A0A0C4DH01|A0A0C4DH01_HUMAN;sp|Q9NVU0|RPC5_HUMAN;tr|H3BNJ0|H3BNJ0_HUMAN",4501,"A0A0C4DH01","A0A0C4DH01_HUMAN",null,null,"POLR3E"]
[1,"19.3462",1,"20.6024",{"$nulls":3},"cerebellar granule cell precursor proliferation;proteasome assembly;proteasome core complex assembly","proteasome binding","cytoplasm;cytosol;endoplasmic reticulum;Golgi apparatus;nucleoplasm;nucleus",{"$nulls":3},3,3,3,"11.8","11.8","11.8","32.854","0.00025707","6.9657",61424000,5,"0.014604",1,"-0.628125","-0.0467905","sp|O95456|PSMG1_HUMAN","sp|O95456|PSMG1_HUMAN",735,"O95456","PSMG1_HUMAN","Proteasome assembly chaperone 1","AC-1","PSMG1"]
["20.584","19.723","20.9331","20.6468",{"$nulls":3},"deoxyribonucleotide biosynthetic process;DNA replication;negative regulation of G0 to G1 transition;nucleobase-containing small molecule interconversion;regulation of transcription involved in G1/S transition of mitotic cell cycle","metal ion binding;ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor","cytosol;ribonucleoside-diphosphate reductase complex","Drug metabolism - other enzymes;Glutathione metabolism;Metabolic pathways;p53 signaling pathway;Purine metabolism;Pyrimidine metabolism",null,null,7,7,7,"24.4","24.4","24.4","44.877",0,"23.092",291510000,21,"0.529119",1,"-0.636468","-1.40297","sp|P31350|RIR2_HUMAN;tr|C9JXC1|C9JXC1_HUMAN","sp|P31350|RIR2_HUMAN",1330,"P31350","RIR2_HUMAN","Ribonucleoside-diphosphate reductase subunit M2",null,"RRM2"]
["18.7448","17.6697","18.9591","18.7354",{"$nulls":3},"peptidyl-diphthamide biosynthetic process from peptidyl-histidine","2-(3-amino-3-carboxypropyl)histidine synthase activity","cytosol",{"$nulls":3},4,4,4,"10.4","10.4","10.4","52.082",0,"10.013",76050000,11,"0.438901",1,"-0.640002","-1.16555","sp|Q9BQC3|DPH2_HUMAN;tr|H0YCR5|H0YCR5_HUMAN","sp|Q9BQC3|DPH2_HUMAN;tr|H0YCR5|H0YCR5_HUMAN",3916,"Q9BQC3","DPH2_HUMAN","2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 {ECO:0000305}",null,"DPH2"]
["19.1793","20.2153","20.1839","20.5003",{"$nulls":5},"integral component of membrane;intracellular membrane-bounded organelle",{"$nulls":3},4,4,4,"9.4","9.4","9.4","53.847",0,"12.072",197940000,12,"0.448572",1,"-0.644771","-1.19055","tr|B7ZKQ9|B7ZKQ9_HUMAN;tr|F5H4X0|F5H4X0_HUMAN;sp|Q8WTV0|SCRB1_HUMAN;tr|F5H5E8|F5H5E8_HUMAN","tr|B7ZKQ9|B7ZKQ9_HUMAN;tr|F5H4X0|F5H4X0_HUMAN;sp|Q8WTV0|SCRB1_HUMAN",5180,"B7ZKQ9","B7ZKQ9_HUMAN"]
["22.2142","22.0593","23.0352","22.5286",{"$nulls":3},"regulation of translational initiation;translational initiation","cadherin binding;GTP binding;GTPase activity;RNA binding;translation factor activity, RNA binding;translation initiation factor activity","cytoplasm;cytosol;plasma membrane","RNA transport",null,null,13,13,13,"33.2","33.2","33.2","49.222",0,"42.624",1339500000,106,"0.868936",1,"-0.645164","-2.43541","sp|P55010|IF5_HUMAN;tr|H0YLZ1|H0YLZ1_HUMAN;tr|H0YN40|H0YN40_HUMAN;tr|H0YMJ8|H0YMJ8_HUMAN;tr|H0YM54|H0YM54_HUMAN;tr|H0YK11|H0YK11_HUMAN;tr|H0YK29|H0YK29_HUMAN","sp|P55010|IF5_HUMAN",1748,"P55010","IF5_HUMAN","Eukaryotic translation initiation factor 5","IF-5","EIF5"]
["20.2253","16.5943","20.3201","17.8039",{"$nulls":3},"chromatin maintenance;DNA duplex unwinding;DNA recombination;mitochondrial mRNA catabolic process;mitochondrial mRNA surveillance;mitochondrial ncRNA surveillance;mitochondrial RNA 3'-end processing;mitochondrial RNA surveillance;mitochondrion morphogenesis;negative regulation of apoptotic process;positive regulation of cell growth;positive regulation of mitochondrial RNA catabolic process;RNA catabolic process","3'-5' RNA helicase activity;ATP binding;ATP-dependent RNA helicase activity;DNA binding;DNA helicase activity;double-stranded RNA binding;helicase activity;protein homodimerization activity;RNA binding","mitochondrial degradosome;mitochondrial matrix;mitochondrial nucleoid;mitochondrion;nucleus",{"$nulls":3},10,10,10,"19.5","19.5","19.5","87.99",0,"26.791",253340000,23,"0.0992948",1,"-0.652205","-0.295271","sp|Q8IYB8|SUV3_HUMAN;tr|B1AR60|B1AR60_HUMAN","sp|Q8IYB8|SUV3_HUMAN",3164,"Q8IYB8","SUV3_HUMAN","ATP-dependent RNA helicase SUPV3L1, mitochondrial",null,"SUPV3L1"]
["18.9612","20.4988","20.1723","20.594",{"$nulls":3},"multicellular organism development;platelet degranulation","cytokine activity","extracellular exosome;extracellular region;platelet dense granule lumen",{"$nulls":3},6,6,6,"32.2","32.2","32.2","24.68",0,"25.17",102310000,20,"0.302158",1,"-0.653176","-0.819325","sp|Q92520|FAM3C_HUMAN;tr|C9JP35|C9JP35_HUMAN;tr|C9JMN4|C9JMN4_HUMAN","sp|Q92520|FAM3C_HUMAN;tr|C9JP35|C9JP35_HUMAN;tr|C9JMN4|C9JMN4_HUMAN",3484,"Q92520","FAM3C_HUMAN","Protein FAM3C",null,"FAM3C"]
["21.5326","19.4097","21.5595","20.7175",{"$nulls":3},"canonical glycolysis;carbohydrate phosphorylation;cellular glucose homeostasis;establishment of protein localization to mitochondrion;glycolytic process;maintenance of protein location in mitochondrion;positive regulation of cytokine secretion involved in immune response;positive regulation of interleukin-1 beta secretion","ATP binding;fructokinase activity;glucokinase activity;glucose binding;hexokinase activity;mannokinase activity;peptidoglycan binding","cytosol;membrane raft;mitochondrial outer membrane;mitochondrion;sperm principal piece","Amino sugar and nucleotide sugar metabolism;Carbohydrate digestion and absorption;Carbon metabolism;Central carbon metabolism in cancer;Fructose and mannose metabolism;Galactose metabolism;Glycolysis / Gluconeogenesis;HIF-1 signaling pathway;Insulin signaling pathway;Metabolic pathways;Neomycin, kanamycin and gentamicin biosynthesis;Starch and sucrose metabolism;Type II diabetes mellitus",null,null,26,26,19,"29.6","29.6","23.7","102.48",0,"113.62",975510000,97,"0.208966",1,"-0.667351","-0.584446","sp|P19367|HXK1_HUMAN;tr|B1AR63|B1AR63_HUMAN;tr|B1AR62|B1AR62_HUMAN;tr|B1AR61|B1AR61_HUMAN","sp|P19367|HXK1_HUMAN",1132,"P19367","HXK1_HUMAN","Hexokinase-1",null,"HK1"]
["21.1819","20.4867","21.339","21.6707",{"$nulls":5},"integral component of membrane;mitochondrial proton-transporting ATP synthase complex",{"$nulls":3},2,2,2,"24.1","24.1","24.1","6.662","0.0065295","2.5562",247480000,35,"0.650099",1,"-0.67054","-1.74094","sp|P56378|68MP_HUMAN;tr|A0A0A0MTQ5|A0A0A0MTQ5_HUMAN;tr|G3V556|G3V556_HUMAN","sp|P56378|68MP_HUMAN;tr|A0A0A0MTQ5|A0A0A0MTQ5_HUMAN;tr|G3V556|G3V556_HUMAN",1780,"P56378","68MP_HUMAN","6.8 kDa mitochondrial proteolipid",null,"MP68"]
["19.3537","19.571","20.2246","20.0521",{"$nulls":3},"protein folding in endoplasmic reticulum",null,"ER membrane protein complex;integral component of membrane",{"$nulls":3},8,8,8,"11.4","11.4","11.4","111.76",0,"20.538",445690000,34,"1.40206",1,"-0.675979","-4.87321","sp|Q8N766|EMC1_HUMAN","sp|Q8N766|EMC1_HUMAN",3259,"Q8N766","EMC1_HUMAN","ER membrane protein complex subunit 1",null,"EMC1"]
["17.8013","17.5724","18.0613","18.6731",{"$nulls":5},"Golgi apparatus;integral component of membrane",{"$nulls":3},4,4,4,"9.7","9.7","9.7","48.864","0.00025297","6.6041",82507000,11,"0.762849",1,"-0.680361","-2.08315","sp|Q6P4E1|CASC4_HUMAN;tr|H0YM51|H0YM51_HUMAN;tr|H0YMR0|H0YMR0_HUMAN","sp|Q6P4E1|CASC4_HUMAN;tr|H0YM51|H0YM51_HUMAN;tr|H0YMR0|H0YMR0_HUMAN",2868,"Q6P4E1","CASC4_HUMAN","Protein CASC4",null,"CASC4"]
["17.0266","17.6083","17.5742","18.4281",{"$nulls":3},"O-glycan processing","magnesium ion binding;manganese ion binding;UDP-xylosyltransferase activity","integral component of endoplasmic reticulum membrane",{"$nulls":3},3,3,3,"10.7","10.7","10.7","43.806","0.00024402","5.8069",61766000,10,"0.499328",1,"-0.683709","-1.32343","sp|Q8NBI6|XXLT1_HUMAN","sp|Q8NBI6|XXLT1_HUMAN",3282,"Q8NBI6","XXLT1_HUMAN","Xyloside xylosyltransferase 1 {ECO:0000303|PubMed:22117070}",null,"XXYLT1"]
["16.5038","14.2829","16.6153","15.545",{"$nulls":5},"mucus layer",{"$nulls":3},4,4,4,"2.2","2.2","2.2","303.38",0,"9.9789",52415000,11,"0.198294",1,"-0.686808","-0.557174","tr|A0A0G2JR65|A0A0G2JR65_HUMAN;sp|Q02817|MUC2_HUMAN;tr|Q9UMI9|Q9UMI9_HUMAN;tr|A0A0G2JM87|A0A0G2JM87_HUMAN","tr|A0A0G2JR65|A0A0G2JR65_HUMAN;sp|Q02817|MUC2_HUMAN",2072,"A0A0G2JR65","A0A0G2JR65_HUMAN",null,null,"MUC2"]
["15.6035","17.2479","17.0355","17.2027",{"$nulls":3},"5S class rRNA transcription from RNA polymerase III type 1 promoter;transcription from RNA polymerase III promoter;transcription initiation from RNA polymerase III promoter;transcription, DNA-templated;tRNA transcription from RNA polymerase III promoter","DNA binding;enzyme activator activity;histone acetyltransferase activity","mitochondrion;nucleoplasm;nucleus;transcription factor TFIIIC complex",{"$nulls":3},6,6,6,"10.2","10.2","10.2","91.981",0,"19.475",162550000,31,"0.309996",1,"-0.693396","-0.838972","sp|Q9UKN8|TF3C4_HUMAN;tr|F2Z356|F2Z356_HUMAN","sp|Q9UKN8|TF3C4_HUMAN",4790,"Q9UKN8","TF3C4_HUMAN","General transcription factor 3C polypeptide 4",null,"GTF3C4"]
["21.0509","20.2552","21.3212","21.3726",{"$nulls":3},"mRNA splicing, via spliceosome;protein folding","peptidyl-prolyl cis-trans isomerase activity","catalytic step 2 spliceosome",{"$nulls":3},3,3,3,"24.2","24.2","24.2","18.154",0,"46.905",196670000,16,"0.649916",1,"-0.693861","-1.74041","sp|Q9H2H8|PPIL3_HUMAN;tr|C9K058|C9K058_HUMAN;tr|B8ZZ77|B8ZZ77_HUMAN;tr|H7BZ14|H7BZ14_HUMAN;tr|F8WC82|F8WC82_HUMAN;tr|C9J4N2|C9J4N2_HUMAN","sp|Q9H2H8|PPIL3_HUMAN;tr|C9K058|C9K058_HUMAN;tr|B8ZZ77|B8ZZ77_HUMAN;tr|H7BZ14|H7BZ14_HUMAN",4170,"Q9H2H8","PPIL3_HUMAN","Peptidyl-prolyl cis-trans isomerase-like 3","PIase","PPIL3"]
["16.451","16.3826","16.821","17.4212",{"$nulls":9},1,1,1,"3.4","3.4","3.4","47.956","0.00046729","4.9102",18580000,1,"0.838805",1,"-0.704339","-2.33203","tr|E7ESJ7|E7ESJ7_HUMAN;sp|Q9NRY5|F1142_HUMAN","tr|E7ESJ7|E7ESJ7_HUMAN;sp|Q9NRY5|F1142_HUMAN",4432,"E7ESJ7","E7ESJ7_HUMAN",null,null,"FAM114A2"]
["20.5993","17.1611","20.7839","18.3867",{"$nulls":3},"blood coagulation;inositol phosphate metabolic process;inositol trisphosphate metabolic process;neural tube development;signal transduction","ATP binding;catalytic activity;inositol tetrakisphosphate 1-kinase activity;inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity;inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity;inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity;inositol-1,3,4-trisphosphate 5-kinase activity;inositol-1,3,4-trisphosphate 6-kinase activity;inositol-3,4,6-trisphosphate 1-kinase activity;isomerase activity;magnesium ion binding","apical plasma membrane;cytosol","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,5,5,5,"20.8","20.8","20.8","45.621",0,"50.87",188730000,11,"0.114322",1,"-0.705071","-0.336439","sp|Q13572|ITPK1_HUMAN;tr|G3V4M9|G3V4M9_HUMAN;tr|G3V588|G3V588_HUMAN;tr|G3V5A3|G3V5A3_HUMAN;tr|G3V3C0|G3V3C0_HUMAN","sp|Q13572|ITPK1_HUMAN;tr|G3V4M9|G3V4M9_HUMAN",2281,"Q13572","ITPK1_HUMAN","Inositol-tetrakisphosphate 1-kinase",null,"ITPK1"]
["20.7695","19.6309","21.4823","20.3491",{"$nulls":3},"defense response",null,"cytoplasm;membrane;nucleus",{"$nulls":3},3,3,3,"15.7","15.7","15.7","28.147",0,"8.8559",140170000,15,"0.330635",1,"-0.715464","-0.890746","sp|Q15773|MLF2_HUMAN;tr|F5H0Y3|F5H0Y3_HUMAN;tr|F5H7L5|F5H7L5_HUMAN;tr|F5H800|F5H800_HUMAN","sp|Q15773|MLF2_HUMAN;tr|F5H0Y3|F5H0Y3_HUMAN",2520,"Q15773","MLF2_HUMAN","Myeloid leukemia factor 2",null,"MLF2"]
["16.5269","16.7486","17.5906","17.1243",{"$nulls":3},"maintenance of translational fidelity;tRNA modification","4 iron, 4 sulfur cluster binding;metal ion binding;N6-threonylcarbomyladenosine methylthiotransferase activity;tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;rough endoplasmic reticulum",{"$nulls":3},3,3,3,"6.4","6.4","6.4","65.111","0.00025826","7.0656",67725000,16,"0.965904",1,"-0.719746","-2.78811","sp|Q5VV42|CDKAL_HUMAN","sp|Q5VV42|CDKAL_HUMAN",2760,"Q5VV42","CDKAL_HUMAN","Threonylcarbamoyladenosine tRNA methylthiotransferase",null,"CDKAL1"]
["14.3702","14.1756","14.4855","15.5057",{"$nulls":3},"blood coagulation;positive regulation of GTPase activity;small GTPase mediated signal transduction","cadherin binding;guanyl-nucleotide exchange factor activity","cytosol;endomembrane system;membrane",{"$nulls":3},10,10,10,"6.8","6.8","6.8","236.44",0,"22.997",89688000,21,"0.524924",1,"-0.722682","-1.39169","sp|Q9BZ29|DOCK9_HUMAN;tr|A0A088AWN3|A0A088AWN3_HUMAN;tr|A0A0A0MRA7|A0A0A0MRA7_HUMAN;tr|A0A0A0MSY4|A0A0A0MSY4_HUMAN;tr|A0A0A0MT38|A0A0A0MT38_HUMAN;tr|H0Y3S1|H0Y3S1_HUMAN;tr|X6RGR3|X6RGR3_HUMAN;tr|Q5JUD8|Q5JUD8_HUMAN;tr|A0A0D9SFH5|A0A0D9SFH5_HUMAN;tr|A0A0D9SF41|A0A0D9SF41_HUMAN;tr|Q5JUD3|Q5JUD3_HUMAN;tr|H7BZ79|H7BZ79_HUMAN","sp|Q9BZ29|DOCK9_HUMAN;tr|A0A088AWN3|A0A088AWN3_HUMAN;tr|A0A0A0MRA7|A0A0A0MRA7_HUMAN;tr|A0A0A0MSY4|A0A0A0MSY4_HUMAN;tr|A0A0A0MT38|A0A0A0MT38_HUMAN",4070,"Q9BZ29","DOCK9_HUMAN","Dedicator of cytokinesis protein 9 {ECO:0000305}",null,"DOCK9"]
["17.9551","18.6286","18.6158","19.4237",{"$nulls":3},"cellular amino acid metabolic process;response to toxic substance;xenobiotic metabolic process","alpha-amino-acid esterase activity;hydrolase activity","extracellular exosome;mitochondrial outer membrane;mitochondrion",{"$nulls":3},1,1,1,"4.5","4.5","4.5","32.542","0.00469","2.8866",61811000,4,"0.522087",1,"-0.727913","-1.38408","sp|Q86WA6|BPHL_HUMAN","sp|Q86WA6|BPHL_HUMAN",3069,"Q86WA6","BPHL_HUMAN","Valacyclovir hydrolase","ACVase;alacyclovirase","BPHL"]
["15.9346","16.7588","16.3591","17.7988",{"$nulls":3},"cellular zinc ion homeostasis;negative regulation of B cell apoptotic process;positive regulation of B cell proliferation;positive regulation of B cell receptor signaling pathway;positive regulation of protein tyrosine phosphatase activity;zinc II ion transmembrane import","zinc ion transmembrane transporter activity","integral component of plasma membrane",{"$nulls":3},7,7,7,11,11,11,"94.131",0,"10.648",52584000,11,"0.327505",1,"-0.732307","-0.88289","sp|Q9ULF5|S39AA_HUMAN;tr|E7ENT5|E7ENT5_HUMAN;tr|E7EV45|E7EV45_HUMAN","sp|Q9ULF5|S39AA_HUMAN",4813,"Q9ULF5","S39AA_HUMAN","Zinc transporter ZIP10",null,"SLC39A10"]
["18.5983","15.3733","18.41","17.0341",{"$nulls":3},"DNA replication;DNA replication initiation;G1/S transition of mitotic cell cycle","ATP binding;DNA replication origin binding;nucleotide binding","cytosol;nuclear chromosome, telomeric region;nuclear origin of replication recognition complex;nucleoplasm;nucleus;origin recognition complex","Cell cycle",null,null,12,12,12,"29.9","29.9","29.9","50.282",0,"32.03",582790000,44,"0.145497",1,"-0.736249","-0.419969","sp|O43913|ORC5_HUMAN;tr|G3V0H0|G3V0H0_HUMAN","sp|O43913|ORC5_HUMAN",450,"O43913","ORC5_HUMAN","Origin recognition complex subunit 5",null,"ORC5"]
["19.99","20.9505","21.3218","21.0996",{"$nulls":3},"cellular response to drug;'de novo' pyrimidine nucleobase biosynthetic process;'de novo' UMP biosynthetic process;female pregnancy;lactation;pyrimidine nucleoside biosynthetic process;UMP biosynthetic process","identical protein binding;orotate phosphoribosyltransferase activity;orotidine-5'-phosphate decarboxylase activity","cytoplasm;cytosol;nucleus","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,12,12,12,"32.7","32.7","32.7","52.221",0,"41.884",508690000,30,"0.565598",1,"-0.740494","-1.50218","sp|P11172|UMPS_HUMAN;tr|E9PFD2|E9PFD2_HUMAN;tr|F2Z3P2|F2Z3P2_HUMAN;tr|F2Z303|F2Z303_HUMAN;tr|F8WDG4|F8WDG4_HUMAN","sp|P11172|UMPS_HUMAN;tr|E9PFD2|E9PFD2_HUMAN",986,"P11172","UMPS_HUMAN","Uridine 5'-monophosphate synthase","MP synthase","UMPS"]
["22.119","20.8156","22.5658","21.8607",{"$nulls":3},"locomotory exploration behavior;pigmentation",null,"extracellular exosome;mitochondrion;nucleoplasm;nucleus",{"$nulls":3},10,10,10,"37.8","37.8","37.8","42.449",0,"144.13",708830000,42,"0.376688",1,"-0.745961","-1.00675","sp|Q9HB07|MYG1_HUMAN;tr|F8VR84|F8VR84_HUMAN;tr|F8VQQ3|F8VQQ3_HUMAN;tr|H3BPH3|H3BPH3_HUMAN","sp|Q9HB07|MYG1_HUMAN;tr|F8VR84|F8VR84_HUMAN;tr|F8VQQ3|F8VQQ3_HUMAN",4301,"Q9HB07","MYG1_HUMAN","UPF0160 protein MYG1, mitochondrial",null,"C12orf10"]
["16.3222","16.5438","16.1898","18.1813",{"$nulls":3},"positive regulation of stress fiber assembly;regulation of Rho protein signal transduction;SREBP signaling pathway","GTPase activator activity;Rho guanyl-nucleotide exchange factor activity","cytosol",{"$nulls":3},19,19,18,22,22,"21.2","115.57",0,"69.858",1063100000,98,"0.274974",1,"-0.752556","-0.751155","tr|Q5VXI4|Q5VXI4_HUMAN;sp|Q9HCE6|ARGAL_HUMAN;tr|E9PB39|E9PB39_HUMAN","tr|Q5VXI4|Q5VXI4_HUMAN;sp|Q9HCE6|ARGAL_HUMAN",4327,"Q5VXI4","Q5VXI4_HUMAN",null,null,"ARHGEF10L"]
["19.6052","18.2155","20.0873","19.2549",{"$nulls":5},"cytosol;mitochondrion",{"$nulls":3},1,1,1,"22.9","22.9","22.9","11.66","0.00026137","7.2992",42733000,6,"0.349936",1,"-0.760777","-0.939257","tr|H3BRW3|H3BRW3_HUMAN;tr|H3BRD2|H3BRD2_HUMAN;sp|P55789|ALR_HUMAN","tr|H3BRW3|H3BRW3_HUMAN;tr|H3BRD2|H3BRD2_HUMAN;sp|P55789|ALR_HUMAN",1770,"H3BRW3","H3BRW3_HUMAN",null,null,"GFER"]
["19.2782","17.6337","19.3752","19.0695",{"$nulls":3},"Golgi organization;protein transport",null,"membrane",{"$nulls":3},9,9,9,23,23,23,"76.078",0,"30.623",222240000,23,"0.340837",1,"-0.766404","-0.916372","tr|B7Z2Y2|B7Z2Y2_HUMAN;sp|Q14746|COG2_HUMAN","tr|B7Z2Y2|B7Z2Y2_HUMAN;sp|Q14746|COG2_HUMAN",2393,"B7Z2Y2","B7Z2Y2_HUMAN",null,null,"COG2"]
["21.1286","19.29","21.4301","20.527",{"$nulls":3},"activation of protein kinase activity;cellular hypotonic response;intracellular signal transduction;negative regulation of potassium ion transmembrane transporter activity;negative regulation of rubidium ion transmembrane transporter activity;peptidyl-threonine phosphorylation;protein phosphorylation;regulation of apoptotic process;regulation of mitotic cell cycle;response to oxidative stress;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;identical protein binding;magnesium ion binding;protein serine/threonine kinase activity;signal transducer, downstream of receptor, with serine/threonine kinase activity","cytoplasm;cytosol;extracellular exosome",{"$nulls":3},11,11,10,"27.5","27.5",26,"58.022",0,"35.304",367120000,51,"0.274929",1,"-0.769228","-0.751041","sp|O95747|OXSR1_HUMAN;tr|C9JIG9|C9JIG9_HUMAN","sp|O95747|OXSR1_HUMAN;tr|C9JIG9|C9JIG9_HUMAN",758,"O95747","OXSR1_HUMAN","Serine/threonine-protein kinase OSR1",null,"OXSR1"]
["20.6661","20.9472","21.2042","21.9575",{"$nulls":3},"L-serine biosynthetic process;L-serine metabolic process;response to mechanical stimulus;response to nutrient levels;response to testosterone","calcium ion binding;magnesium ion binding;phosphoserine phosphatase activity;protein homodimerization activity","cytosol;neuron projection","Biosynthesis of amino acids;Carbon metabolism;Glycine, serine and threonine metabolism;Metabolic pathways",null,null,8,8,8,"47.1","47.1","47.1","25.007",0,"44.733",426820000,38,"0.712204",1,"-0.774163","-1.92572","sp|P78330|SERB_HUMAN;tr|C9JBI3|C9JBI3_HUMAN","sp|P78330|SERB_HUMAN;tr|C9JBI3|C9JBI3_HUMAN",1970,"P78330","SERB_HUMAN","Phosphoserine phosphatase","SP;SPase","PSPH"]
["19.5212","18.3849","20.3724","19.09",{"$nulls":3},"negative regulation of intracellular estrogen receptor signaling pathway;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of transcription from RNA polymerase II promoter;response to estradiol","armadillo repeat domain binding;calmodulin binding;DNA binding transcription factor activity;protein complex binding;protein phosphatase 2A binding","cytoplasm;dendrite;Golgi apparatus;neuronal cell body;nucleoplasm;nucleus;plasma membrane;protein complex",{"$nulls":3},9,9,9,"18.1","18.1","18.1","87.208",0,"23.992",195750000,28,"0.337642",1,"-0.778172","-0.908344","sp|Q13033|STRN3_HUMAN;tr|G3V340|G3V340_HUMAN;tr|G3V3G7|G3V3G7_HUMAN;tr|H0YJZ4|H0YJZ4_HUMAN;tr|H0YJT2|H0YJT2_HUMAN","sp|Q13033|STRN3_HUMAN;tr|G3V340|G3V340_HUMAN",2195,"Q13033","STRN3_HUMAN","Striatin-3",null,"STRN3"]
["24.0773","23.2988","25.0416","23.8961",{"$nulls":3},"covalent chromatin modification;histone exchange;nucleocytoplasmic transport;nucleosome assembly;regulation of apoptotic process","histone binding;phosphatase inhibitor activity","cytoplasmic vesicle;nucleus;Swr1 complex",{"$nulls":3},5,5,3,"22.8","22.8","13.4","30.692",0,"100.65",1397700000,23,"0.424075",1,"-0.780765","-1.12742","sp|Q9BTT0|AN32E_HUMAN;tr|Q5TB19|Q5TB19_HUMAN;tr|E9PLC4|E9PLC4_HUMAN","sp|Q9BTT0|AN32E_HUMAN;tr|Q5TB19|Q5TB19_HUMAN;tr|E9PLC4|E9PLC4_HUMAN",3969,"Q9BTT0","AN32E_HUMAN","Acidic leucine-rich nuclear phosphoprotein 32 family member E",null,"ANP32E"]
["20.1286","19.4085","20.7905","20.3418",{"$nulls":3},"cell division;cell separation after cytokinesis;ESCRT III complex disassembly;establishment of protein localization;mitotic metaphase plate congression;multivesicular body assembly;nucleus organization;protein transport;regulation of centrosome duplication;regulation of mitotic spindle assembly;vacuolar transport;viral budding via host ESCRT complex","identical protein binding;protein domain specific binding","cytosol;endosome membrane;ESCRT III complex;extracellular exosome;late endosome membrane;membrane coat;midbody;nucleus","Endocytosis;Necroptosis",null,null,2,2,2,"8.5","8.5","8.5","22.109","0.00068556","4.4929",100970000,11,"0.697185",1,"-0.797647","-1.88024","sp|Q7LBR1|CHM1B_HUMAN","sp|Q7LBR1|CHM1B_HUMAN",2979,"Q7LBR1","CHM1B_HUMAN","Charged multivesicular body protein 1b",null,"CHMP1B"]
["13.889",1,"15.5",1,{"$nulls":3},"actin cytoskeleton organization;brain development;cellular response to lipopolysaccharide;definitive hemopoiesis;homeostasis of number of cells;inner ear morphogenesis;intracellular protein transmembrane transport;intracellular signal transduction;negative regulation of blood vessel remodeling;negative regulation of cellular extravasation;negative regulation of inflammatory response;negative regulation of neutrophil degranulation;negative regulation of reactive oxygen species metabolic process;negative regulation of respiratory burst;neuromuscular process controlling balance;platelet-derived growth factor receptor signaling pathway;positive regulation of GTPase activity;positive regulation of phagocytosis;protein autophosphorylation;protein phosphorylation;regulation of cell cycle;regulation of nitrogen compound metabolic process;regulation of Rho protein signal transduction;regulation of small GTPase mediated signal transduction;regulation of vascular permeability;renal system process;signal transduction","ATP binding;GTPase activator activity;kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity;Rho guanyl-nucleotide exchange factor activity","cell junction;cytosol;extracellular exosome;membrane;postsynaptic density;postsynaptic membrane;protein complex","Chronic myeloid leukemia;Pathways in cancer",null,null,4,3,3,"3.9","3.1","3.1","142.82",0,"8.2415",62235000,13,"0.0262331",1,"-0.805487","-0.083038","sp|P11274|BCR_HUMAN;tr|H0Y554|H0Y554_HUMAN;tr|A9UF01|A9UF01_HUMAN","sp|P11274|BCR_HUMAN;tr|H0Y554|H0Y554_HUMAN;tr|A9UF01|A9UF01_HUMAN",992,"P11274","BCR_HUMAN","Breakpoint cluster region protein",null,"BCR"]
["20.1245","19.0621","20.2966","20.5168",{"$nulls":3},"translation","structural constituent of ribosome","ribosome",{"$nulls":3},2,2,2,"26.9","26.9","26.9","10.474","0.00068571","4.4941",86049000,8,"0.564559",1,"-0.813405","-1.49933","tr|D6RAN8|D6RAN8_HUMAN;tr|H7C5U8|H7C5U8_HUMAN;sp|Q9P0M9|RM27_HUMAN","tr|D6RAN8|D6RAN8_HUMAN;tr|H7C5U8|H7C5U8_HUMAN;sp|Q9P0M9|RM27_HUMAN",4619,"D6RAN8","D6RAN8_HUMAN"]
["19.2535","17.8087","19.7303","18.9668",{"$nulls":3},"cell-cell signaling;protein transport;signal transduction","receptor binding","endoplasmic reticulum;endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment;endoplasmic reticulum-Golgi intermediate compartment membrane;Golgi apparatus;integral component of membrane;intracellular membrane-bounded organelle;plasma membrane",{"$nulls":3},2,2,2,"9.7","9.7","9.7","25.206","0.001506","3.6059",26400000,5,"0.374233",1,"-0.817494","-1.00054","sp|Q13445|TMED1_HUMAN;tr|K7EIN4|K7EIN4_HUMAN;tr|K7EQ63|K7EQ63_HUMAN","sp|Q13445|TMED1_HUMAN;tr|K7EIN4|K7EIN4_HUMAN;tr|K7EQ63|K7EQ63_HUMAN",2259,"Q13445","TMED1_HUMAN","Transmembrane emp24 domain-containing protein 1",null,"TMED1"]
["16.9752","15.1942","17.3344","16.493",{"$nulls":3},"intracellular signal transduction;negative regulation of GTPase activity;regulation of small GTPase mediated signal transduction","GTPase activator activity;metal ion binding","cytosol;intracellular;nucleoplasm;plasma membrane",{"$nulls":3},3,3,3,"4.9","4.9","4.9","106.68","0.00026144","7.3005",46499000,14,"0.31109",1,"-0.828994","-0.841715","sp|Q9P107|GMIP_HUMAN","sp|Q9P107|GMIP_HUMAN",4624,"Q9P107","GMIP_HUMAN","GEM-interacting protein","MIP","GMIP"]
[1,"18.8861",1,"20.5632",{"$nulls":3},"amino acid transport;transport","amino acid transmembrane transporter activity;arginine transmembrane transporter activity","integral component of plasma membrane;membrane;plasma membrane","MicroRNAs in cancer",null,null,4,4,4,"7.6","7.6","7.6","67.638",0,"9.7183",77814000,5,"0.0198574",1,"-0.838553","-0.0632699","sp|P30825|CTR1_HUMAN;tr|Q5JR49|Q5JR49_HUMAN","sp|P30825|CTR1_HUMAN",1319,"P30825","CTR1_HUMAN","High affinity cationic amino acid transporter 1","AT1;AT-1 {ECO:0000303|PubMed:10485994}","SLC7A1"]
["16.5552","18.1109","18.4118","17.9482",{"$nulls":3},"cell cycle G2/M phase transition;mitotic chromosome condensation;mRNA processing;nuclear envelope disassembly;positive regulation of histone deacetylation;positive regulation of transcription from RNA polymerase II promoter;regulation of histone phosphorylation;regulation of mRNA export from nucleus;RNA splicing;transcription, DNA-templated","DEAD/H-box RNA helicase binding;DNA binding;histone deacetylase binding;lamin binding;metal ion binding;protein kinase A regulatory subunit binding;RNA binding","chromatin;cytoplasm;intracellular ribonucleoprotein complex;nuclear matrix;nuclear speck;nucleus;PML body",{"$nulls":3},5,5,5,"12.5","12.5","12.5","71.648",0,"14.693",132870000,17,"0.391166",1,"-0.846942","-1.04344","sp|Q9ULX6|AKP8L_HUMAN;tr|V9GZ50|V9GZ50_HUMAN;tr|M0R1Y5|M0R1Y5_HUMAN;tr|M0QYT7|M0QYT7_HUMAN","sp|Q9ULX6|AKP8L_HUMAN",4830,"Q9ULX6","AKP8L_HUMAN","A-kinase anchor protein 8-like","KAP8-like protein","AKAP8L"]
["18.2757","16.1243","17.8397","18.2827",{"$nulls":3},"actin cytoskeleton reorganization;cell adhesion;cell projection assembly;establishment or maintenance of cell polarity regulating cell shape;lamellipodium assembly","actin binding","cytoskeleton;cytosol;focal adhesion;lamellipodium;plasma membrane;Z disc","Focal adhesion",null,null,6,4,4,"17.9","12.1","12.1","41.714",0,"8.7896",39762000,10,"0.288118",1,"-0.861193","-0.784127","sp|Q9HBI1|PARVB_HUMAN;tr|A0A087WZB5|A0A087WZB5_HUMAN;tr|B0QYP8|B0QYP8_HUMAN","sp|Q9HBI1|PARVB_HUMAN;tr|A0A087WZB5|A0A087WZB5_HUMAN",4310,"Q9HBI1","PARVB_HUMAN","Beta-parvin",null,"PARVB"]
["18.7531","22.9422","21.3396","22.102",{"$nulls":3},"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay;maturation of SSU-rRNA;mRNA splicing, via spliceosome;RNA splicing;tRNA processing","RNA binding","cytosol;extracellular exosome;nucleolus;nucleoplasm;P-body;small nuclear ribonucleoprotein complex;small nucleolar ribonucleoprotein complex;spliceosomal complex;U4/U6 x U5 tri-snRNP complex;U6 snRNP","RNA degradation;Spliceosome",null,null,4,4,4,"42.5","42.5","42.5","9.1275","0.000258","7.0409",188130000,12,"0.141786",1,"-0.873167","-0.410142","sp|P62312|LSM6_HUMAN","sp|P62312|LSM6_HUMAN",1890,"P62312","LSM6_HUMAN","U6 snRNA-associated Sm-like protein LSm6",null,"LSM6"]
["18.4905","16.3857","18.6143","18.0306",{"$nulls":3},"phosphatidylinositol dephosphorylation","hydrolase activity",{"$nulls":4},6,6,6,"7.2","7.2","7.2","126.52",0,"12.557",152870000,16,"0.298334",1,"-0.884302","-0.809738","tr|A0A0A0MTP6|A0A0A0MTP6_HUMAN;sp|O15357|SHIP2_HUMAN;tr|F5GY16|F5GY16_HUMAN","tr|A0A0A0MTP6|A0A0A0MTP6_HUMAN;sp|O15357|SHIP2_HUMAN",355,"A0A0A0MTP6","A0A0A0MTP6_HUMAN",null,null,"INPPL1"]
["18.63","14.076","18.0916","16.4102",{"$nulls":3},"mRNA splicing, via spliceosome;positive regulation of G1/S transition of mitotic cell cycle;protein localization to nucleus",null,"catalytic step 2 spliceosome;Cul4-RING E3 ubiquitin ligase complex;fibrillar center;nuclear membrane;nuclear speck;nucleoplasm;precatalytic spliceosome;Prp19 complex","Spliceosome",null,null,8,8,8,"27.2","27.2","27.2","57.193",0,"90.506",552730000,71,"0.126713",1,"-0.897883","-0.369919","sp|O43660|PLRG1_HUMAN;tr|D6RA26|D6RA26_HUMAN;tr|H0YA24|H0YA24_HUMAN;tr|H0YAA2|H0YAA2_HUMAN;tr|B7Z982|B7Z982_HUMAN","sp|O43660|PLRG1_HUMAN",415,"O43660","PLRG1_HUMAN","Pleiotropic regulator 1",null,"PLRG1"]
["21.0136","19.5981","21.3927","21.028",{"$nulls":3},"mitochondrial translational elongation;mitochondrial translational termination;mitotic cell cycle arrest;viral process",null,"mitochondrial matrix;mitochondrial ribosome;mitochondrion;nucleus",{"$nulls":3},5,5,5,"31.5","31.5","31.5","25.384",0,"14.718",250030000,35,"0.466671",1,"-0.904482","-1.23758","sp|Q8TAE8|G45IP_HUMAN","sp|Q8TAE8|G45IP_HUMAN",3357,"Q8TAE8","G45IP_HUMAN","Growth arrest and DNA damage-inducible proteins-interacting protein 1",null,"GADD45GIP1"]
["13.8295",1,1,"15.6396",{"$nulls":3},"regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity","cytosol",{"$nulls":3},13,13,13,"18.3","18.3","18.3","116.93",0,"43.393",306150000,44,"0.0294725",1,"-0.905049","-0.0929889","sp|O94988|FA13A_HUMAN;tr|E9PGM7|E9PGM7_HUMAN;tr|D6RD35|D6RD35_HUMAN;tr|D6RIY4|D6RIY4_HUMAN","sp|O94988|FA13A_HUMAN;tr|E9PGM7|E9PGM7_HUMAN",682,"O94988","FA13A_HUMAN","Protein FAM13A",null,"FAM13A"]
["19.7952","18.6122","20.8444","19.4011",{"$nulls":3},"retrograde protein transport, ER to cytosol;ubiquitin-dependent ERAD pathway","ubiquitin binding;ubiquitin-protein transferase activator activity","extracellular exosome;Hrd1p ubiquitin ligase ERAD-L complex;integral component of endoplasmic reticulum membrane;membrane",{"$nulls":3},5,5,5,13,13,13,"53.028",0,"23.652",396770000,60,"0.368086",1,"-0.919113","-0.985006","sp|Q9Y679|AUP1_HUMAN","sp|Q9Y679|AUP1_HUMAN",5080,"Q9Y679","AUP1_HUMAN","Ancient ubiquitous protein 1",null,"AUP1"]
["18.4497","19.8399","19.3216","20.8278",{"$nulls":3},"cilium assembly;histone H3 acetylation;histone H3-K4 methylation;histone H4-K16 acetylation;histone H4-K5 acetylation;histone H4-K8 acetylation;neuron projection development;positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter;post-translational protein modification;regulation of megakaryocyte differentiation;skeletal system development;transcription, DNA-templated","histone-lysine N-methyltransferase activity;methylated histone binding","Ada2/Gcn5/Ada3 transcription activator complex;ciliary basal body;histone acetyltransferase complex;histone methyltransferase complex;MLL1 complex;MLL3/4 complex;nucleoplasm;nucleus;Set1C/COMPASS complex","Cushing syndrome",null,null,5,5,5,"22.5","22.5","22.5","36.588",0,"14.975",211220000,32,"0.337252",1,"-0.929901","-0.907364","sp|P61964|WDR5_HUMAN;tr|V9GZ59|V9GZ59_HUMAN;tr|V9GYQ5|V9GYQ5_HUMAN","sp|P61964|WDR5_HUMAN",1863,"P61964","WDR5_HUMAN","WD repeat-containing protein 5",null,"WDR5"]
["15.7198","15.621","16.6815","16.5281",{"$nulls":3},"basal protein localization;cell adhesion;cell cycle;cell growth;cellular response to tumor necrosis factor;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;establishment or maintenance of epithelial cell apical/basal polarity;integrin-mediated signaling pathway;intermediate filament cytoskeleton organization;negative regulation of monocyte chemotactic protein-1 production;negative regulation of NF-kappaB transcription factor activity;negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;protein targeting;response to lipopolysaccharide;response to muramyl dipeptide;signal transduction","ErbB-2 class receptor binding;integrin binding;receptor binding;structural constituent of cytoskeleton","basal plasma membrane;basement membrane;basolateral plasma membrane;cell junction;cytoplasm;hemidesmosome;nuclear membrane;nuclear speck;nucleus;plasma membrane","NOD-like receptor signaling pathway",null,null,8,8,8,"8.7","8.7","8.7","158.3",0,"11.456",67385000,12,"2.02661",1,"-0.934402","-10.2382","sp|Q96RT1|LAP2_HUMAN;tr|B4DIP2|B4DIP2_HUMAN","sp|Q96RT1|LAP2_HUMAN",3809,"Q96RT1","ERBIN_HUMAN","Erbin {ECO:0000303|PubMed:10878805}",null,"ERBIN"]
["18.9656","19.0095","19.9476","19.91",{"$nulls":3},"protein transport",null,"integral component of membrane;mitochondrial inner membrane",{"$nulls":3},7,7,7,"50.7","50.7","50.7","16.383",0,"21.256",327000000,35,"3.02588",1,"-0.941257","-32.556","sp|Q9Y5T4|DJC15_HUMAN","sp|Q9Y5T4|DJC15_HUMAN",5055,"Q9Y5T4","DJC15_HUMAN","DnaJ homolog subfamily C member 15",null,"DNAJC15"]
["16.6204","18.5528","19.086","17.9905",{"$nulls":3},"execution phase of apoptosis;neurotransmitter receptor metabolic process;positive regulation of deacetylase activity;positive regulation of tubulin deacetylation;protein farnesylation;protein geranylgeranylation;regulation of rhodopsin mediated signaling pathway;skeletal muscle acetylcholine-gated channel clustering;transforming growth factor beta receptor signaling pathway","acetylcholine receptor regulator activity;alpha-tubulin binding;CAAX-protein geranylgeranyltransferase activity;microtubule binding;protein farnesyltransferase activity;protein geranylgeranyltransferase activity;Rab geranylgeranyltransferase activity;receptor tyrosine kinase binding","CAAX-protein geranylgeranyltransferase complex;cytoplasm;cytosol;microtubule associated complex;plasma membrane;protein farnesyltransferase complex","Terpenoid backbone biosynthesis",null,null,7,7,7,"24.3","24.3","24.3","44.408",0,"13.395",350610000,14,"0.317113",1,"-0.951648","-0.856818","sp|P49354|FNTA_HUMAN;tr|B3KVN2|B3KVN2_HUMAN;tr|E9PQP6|E9PQP6_HUMAN;tr|H0YCW1|H0YCW1_HUMAN;tr|E9PPM9|E9PPM9_HUMAN","sp|P49354|FNTA_HUMAN;tr|B3KVN2|B3KVN2_HUMAN;tr|E9PQP6|E9PQP6_HUMAN",1566,"P49354","FNTA_HUMAN","Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha",null,"FNTA"]
["20.0189","20.5929","20.5268","22.007",{"$nulls":4},"RNA binding","cytosol",{"$nulls":3},12,12,10,"28.2","28.2","25.2","54.945",0,"42.102",627650000,63,"0.456324",1,"-0.96103","-1.21065","tr|A0A087X1A5|A0A087X1A5_HUMAN;sp|O95793|STAU1_HUMAN;tr|Q5JW30|Q5JW30_HUMAN;tr|Q5JW28|Q5JW28_HUMAN;tr|F6UDC6|F6UDC6_HUMAN","tr|A0A087X1A5|A0A087X1A5_HUMAN;sp|O95793|STAU1_HUMAN;tr|Q5JW30|Q5JW30_HUMAN",764,"A0A087X1A5","A0A087X1A5_HUMAN",null,null,"STAU1"]
["20.7964","18.546","20.8568","20.4232",{"$nulls":3},"guanine catabolic process;guanine metabolic process;nervous system development;nucleobase-containing compound metabolic process;purine nucleotide catabolic process","guanine deaminase activity;zinc ion binding","cytosol;extracellular exosome;intracellular","Metabolic pathways;Purine metabolism",null,null,7,7,7,"22.5","22.5","22.5","51.002",0,"149.45",331280000,29,"0.312582",1,"-0.968813","-0.845456","sp|Q9Y2T3|GUAD_HUMAN;tr|Q5SZC6|Q5SZC6_HUMAN;tr|H0YDZ7|H0YDZ7_HUMAN;tr|Q5SZC3|Q5SZC3_HUMAN;tr|Q5SZC5|Q5SZC5_HUMAN","sp|Q9Y2T3|GUAD_HUMAN;tr|Q5SZC6|Q5SZC6_HUMAN;tr|H0YDZ7|H0YDZ7_HUMAN;tr|Q5SZC3|Q5SZC3_HUMAN",4938,"Q9Y2T3","GUAD_HUMAN","Guanine deaminase","uanase;uanine aminase","GDA"]
["17.1344","14.3727","17.4396","16.0129",{"$nulls":9},7,7,7,"6.4","6.4","6.4","224.47",0,"13.756",108670000,15,"0.225247",1,"-0.972695","-0.625832","tr|H0Y764|H0Y764_HUMAN;sp|Q6ZNJ1|NBEL2_HUMAN;tr|H7C3Y7|H7C3Y7_HUMAN;tr|H7C408|H7C408_HUMAN","tr|H0Y764|H0Y764_HUMAN;sp|Q6ZNJ1|NBEL2_HUMAN;tr|H7C3Y7|H7C3Y7_HUMAN",2930,"H0Y764","H0Y764_HUMAN",null,null,"NBEAL2"]
["21.4395","21.4183","21.5584","23.2522",{"$nulls":3},"neutrophil degranulation;post-Golgi vesicle-mediated transport;protein transport",null,"clathrin-coated vesicle;integral component of membrane;plasma membrane;recycling endosome membrane;specific granule membrane;synaptic vesicle membrane;trans-Golgi network;zymogen granule membrane",{"$nulls":3},8,8,8,"34.3","34.3","34.3","37.92",0,"44.081",596890000,27,"0.433979",1,"-0.976434","-1.15287","sp|O15126|SCAM1_HUMAN;tr|A0A087WXB0|A0A087WXB0_HUMAN;tr|A0A087WZA6|A0A087WZA6_HUMAN;tr|A0A087WTX8|A0A087WTX8_HUMAN;tr|A0A087WU14|A0A087WU14_HUMAN","sp|O15126|SCAM1_HUMAN;tr|A0A087WXB0|A0A087WXB0_HUMAN;tr|A0A087WZA6|A0A087WZA6_HUMAN",327,"O15126","SCAM1_HUMAN","Secretory carrier-associated membrane protein 1","ecretory carrier membrane protein 1","SCAMP1"]
["18.7498","17.2249","18.7456","19.1934",{"$nulls":3},"histone H3-K27 trimethylation;histone H3-K4 trimethylation;negative regulation of transcription from RNA polymerase II promoter;nucleosome assembly;nucleosome positioning","chromatin DNA binding;RNA binding","nuclear chromatin;nuclear euchromatin;nucleosome",{"$nulls":3},7,1,1,"27.1","7.2","7.2","22.35",0,"10.166",406620000,13,"0.466026",1,"-0.982147","-1.2359","sp|P16402|H13_HUMAN;sp|P22492|H1T_HUMAN;sp|Q02539|H11_HUMAN","sp|P16402|H13_HUMAN",1080,"P16402","H13_HUMAN","Histone H1.3",null,"HIST1H1D"]
["21.0725","21.0691","21.6211","22.5076",{"$nulls":3},"actin cytoskeleton organization;chemical synaptic transmission;ephrin receptor signaling pathway;intracellular signal transduction;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of receptor internalization;neutrophil degranulation;positive regulation of cell growth;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of epithelial to mesenchymal transition;positive regulation of exosomal secretion;positive regulation of extracellular exosome assembly;positive regulation of JNK cascade;positive regulation of pathway-restricted SMAD protein phosphorylation;positive regulation of phosphorylation;positive regulation of transforming growth factor beta receptor signaling pathway;protein targeting to membrane;regulation of mitotic cell cycle;substrate-dependent cell migration, cell extension","cadherin binding;cytoskeletal adaptor activity;frizzled binding;identical protein binding;interleukin-5 receptor binding;phosphatidylinositol-4,5-bisphosphate binding;protein heterodimerization activity;protein N-terminus binding;syndecan binding","adherens junction;azurophil granule lumen;blood microparticle;cytoplasm;cytoskeleton;cytosol;endoplasmic reticulum membrane;extracellular exosome;extracellular region;extracellular space;extracellular vesicle;focal adhesion;interleukin-5 receptor complex;intracellular membrane-bounded organelle;melanosome;membrane;membrane raft;nuclear membrane;nucleoplasm;nucleus;plasma membrane",{"$nulls":3},7,7,1,45,45,6,"32.444",0,"159.38",752480000,76,"0.811807",1,"-0.993585","-2.2417","sp|O00560|SDCB1_HUMAN;tr|B4DHN5|B4DHN5_HUMAN;tr|E9PBU7|E9PBU7_HUMAN","sp|O00560|SDCB1_HUMAN;tr|B4DHN5|B4DHN5_HUMAN;tr|E9PBU7|E9PBU7_HUMAN",242,"O00560","SDCB1_HUMAN","Syntenin-1",null,"SDCBP"]
[1,"16.5397",1,"18.5311",{"$nulls":3},"aging;cerebellum development;in utero embryonic development;mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly;response to ethanol;response to hypoxia;response to nicotine","NADH dehydrogenase (ubiquinone) activity","integral component of membrane;mitochondrial inner membrane;mitochondrial respiratory chain complex I","Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,2,2,2,"5.7","5.7","5.7","51.58","0.0023119","3.3083",6379700,1,"0.0268712",1,"-0.995683","-0.085003","sp|P03905|NU4M_HUMAN","sp|P03905|NU4M_HUMAN",826,"P03905","NU4M_HUMAN","NADH-ubiquinone oxidoreductase chain 4",null,"MT-ND4"]
["20.2423","18.0386","20.7363","19.5622",{"$nulls":3},"antigen processing and presentation of exogenous peptide antigen via MHC class II;antigen processing and presentation of peptide antigen via MHC class I;cargo loading into COPII-coated vesicle;COPII vesicle coating;ER to Golgi vesicle-mediated transport;IRE1-mediated unfolded protein response;protein transport;response to calcium ion","calcium-dependent protein binding","COPII vesicle coat;COPII-coated ER to Golgi transport vesicle;cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum exit site;endoplasmic reticulum membrane;ER to Golgi transport vesicle membrane;Golgi membrane;intracellular membrane-bounded organelle;perinuclear region of cytoplasm;vesicle coat","Protein processing in endoplasmic reticulum",null,null,18,18,18,"18.5","18.5","18.5","133.01",0,"63.504",1111700000,47,"0.297668",1,"-1.00884","-0.808068","sp|O94979|SC31A_HUMAN;tr|D6REX3|D6REX3_HUMAN;tr|H7BXG7|H7BXG7_HUMAN;tr|D6RHZ5|D6RHZ5_HUMAN;tr|H0Y8W8|H0Y8W8_HUMAN;tr|H0YAB3|H0YAB3_HUMAN;tr|H0YAF5|H0YAF5_HUMAN;tr|H0Y9T9|H0Y9T9_HUMAN;tr|H0Y9K1|H0Y9K1_HUMAN;tr|H0Y8V7|H0Y8V7_HUMAN;tr|D6RE64|D6RE64_HUMAN;tr|D6RCQ9|D6RCQ9_HUMAN;tr|H0Y9V3|H0Y9V3_HUMAN;tr|D6RBT0|D6RBT0_HUMAN;tr|D6RHE8|D6RHE8_HUMAN","sp|O94979|SC31A_HUMAN;tr|D6REX3|D6REX3_HUMAN;tr|H7BXG7|H7BXG7_HUMAN;tr|D6RHZ5|D6RHZ5_HUMAN",681,"O94979","SC31A_HUMAN","Protein transport protein Sec31A",null,"SEC31A"]
["14.8153",1,"16.8717",1,{"$nulls":3},"histone H3 acetylation;transcription from RNA polymerase II promoter","DNA binding transcription factor activity;transcription coactivator activity","cytoplasmic ribonucleoprotein granule;nuclear speck;nucleus;STAGA complex;transcription factor TFTC complex","Basal transcription factors",null,null,7,7,7,"14.9","14.9","14.9","66.155",0,"20.846",239900000,29,"0.0310217",1,"-1.02819","-0.0977264","sp|O75529|TAF5L_HUMAN","sp|O75529|TAF5L_HUMAN",582,"O75529","TAF5L_HUMAN","TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L",null,"TAF5L"]
["15.9256","13.6849","15.8484","15.8354",{"$nulls":5},"mitochondrion",{"$nulls":3},3,3,3,"0.5","0.5","0.5","780.6","0.0079906","2.3765",140140000,8,"0.344392",1,"-1.03669","-0.92531","sp|Q5CZC0|FSIP2_HUMAN;tr|J3QTJ6|J3QTJ6_HUMAN","sp|Q5CZC0|FSIP2_HUMAN;tr|J3QTJ6|J3QTJ6_HUMAN",2681,"Q5CZC0","FSIP2_HUMAN","Fibrous sheath-interacting protein 2",null,"FSIP2"]
["17.6996","15.4854","18.8246","16.4603",{"$nulls":3},"mRNA splicing, via spliceosome;RNA processing;RNA splicing;RNA splicing, via transesterification reactions","U4 snRNA binding;U6 snRNA binding","Cajal body;nuclear speck;nucleoplasm;nucleus;spliceosomal complex;spliceosomal snRNP complex;U4/U6 snRNP;U4/U6 x U5 tri-snRNP complex","Spliceosome",null,null,12,12,12,"29.1","29.1","29.1","58.449",0,"39.321",639480000,59,"0.234104",1,"-1.04995","-0.648257","sp|O43172|PRP4_HUMAN","sp|O43172|PRP4_HUMAN",378,"O43172","PRP4_HUMAN","U4/U6 small nuclear ribonucleoprotein Prp4",null,"PRPF4"]
["19.7668","20.3954","20.3206","21.9502",{"$nulls":3},"actin filament depolymerization;actin filament fragmentation;muscle cell cellular homeostasis;positive regulation of actin filament depolymerization;sarcomere organization;skeletal muscle tissue development","actin filament binding","actin cytoskeleton;extracellular exosome;extracellular space;I band;nuclear matrix;Z disc","Axon guidance;Fc gamma R-mediated phagocytosis;Human immunodeficiency virus 1 infection;Pertussis;Regulation of actin cytoskeleton",null,null,7,3,3,"46.4","25.3","25.3","18.736",0,"60.534",146540000,14,"0.454999",1,"-1.05428","-1.20721","sp|Q9Y281|COF2_HUMAN;tr|F8WDN3|F8WDN3_HUMAN","sp|Q9Y281|COF2_HUMAN",4901,"Q9Y281","COF2_HUMAN","Cofilin-2",null,"CFL2"]
["20.7883","18.6081","20.8843","20.6554",{"$nulls":3},"metabolic process","calcium ion binding;transferase activity, transferring acyl groups",{"$nulls":4},6,6,6,"23.3","23.3","23.3","54.472",0,"27.247",268120000,19,"0.365203",1,"-1.07165","-0.97773","tr|A0A0G2JQ62|A0A0G2JQ62_HUMAN;sp|Q8NF37|PCAT1_HUMAN;tr|A0A0G2JRI7|A0A0G2JRI7_HUMAN","tr|A0A0G2JQ62|A0A0G2JQ62_HUMAN;sp|Q8NF37|PCAT1_HUMAN;tr|A0A0G2JRI7|A0A0G2JRI7_HUMAN",3332,"A0A0G2JQ62","A0A0G2JQ62_HUMAN",null,null,"LPCAT1"]
["16.2323","15.2986","18.8423","14.88",{"$nulls":3},"anaphase-promoting complex-dependent catabolic process;cell division;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;proteasome-mediated ubiquitin-dependent protein catabolic process;protein K11-linked ubiquitination;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle",null,"anaphase-promoting complex;cytosol;nucleoplasm","Cell cycle;Human T-cell leukemia virus 1 infection;Oocyte meiosis;Progesterone-mediated oocyte maturation;Ubiquitin mediated proteolysis",null,null,3,3,3,"2.6","2.6","2.6","216.5",0,"9.7338",87566000,8,"0.190943",1,"-1.09569","-0.538316","sp|Q9H1A4|APC1_HUMAN;tr|H0Y564|H0Y564_HUMAN","sp|Q9H1A4|APC1_HUMAN",4152,"Q9H1A4","APC1_HUMAN","Anaphase-promoting complex subunit 1","PC1","ANAPC1"]
["19.08","20.4848","20.8025","20.9612",{"$nulls":3},"methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione","hydroxyacylglutathione hydrolase activity",{"$nulls":4},4,4,4,"25.1","25.1","25.1","26.305",0,"11.126",162750000,5,"0.584812",1,"-1.09939","-1.55532","tr|H3BPK3|H3BPK3_HUMAN;tr|H3BPQ4|H3BPQ4_HUMAN;sp|Q16775|GLO2_HUMAN;tr|H3BQW8|H3BQW8_HUMAN;tr|H3BV79|H3BV79_HUMAN","tr|H3BPK3|H3BPK3_HUMAN;tr|H3BPQ4|H3BPQ4_HUMAN;sp|Q16775|GLO2_HUMAN;tr|H3BQW8|H3BQW8_HUMAN",2572,"H3BPK3","H3BPK3_HUMAN",null,null,"HAGH"]
["17.754","15.4735","18.1649","17.3001",{"$nulls":4},"ATP binding;transmembrane receptor protein tyrosine kinase activity","cytosol;integral component of membrane;plasma membrane",{"$nulls":3},5,4,4,"7.9","6.6","6.6","107.57","0.00025733","6.9934",67431000,3,"0.341238",1,"-1.11874","-0.91738","tr|B4DTR1|B4DTR1_HUMAN;sp|P04626|ERBB2_HUMAN;tr|J3QLU9|J3QLU9_HUMAN;tr|J3QRX1|J3QRX1_HUMAN;tr|F5H1T4|F5H1T4_HUMAN","tr|B4DTR1|B4DTR1_HUMAN;sp|P04626|ERBB2_HUMAN;tr|J3QLU9|J3QLU9_HUMAN",843,"B4DTR1","B4DTR1_HUMAN","Receptor protein-tyrosine kinase {ECO:0000256|SAAS:SAAS00593197}",null,"ERBB2"]
["17.2832",1,"19.5533",1,{"$nulls":3},"intestinal epithelial cell development","identical protein binding","cis-Golgi network;COPII-coated ER to Golgi transport vesicle;endoplasmic reticulum;Golgi medial cisterna;Golgi membrane;Golgi trans cisterna;integral component of membrane;trans-Golgi network",{"$nulls":3},3,3,3,"12.7","12.7","12.7","26.256",0,"9.3231",82953000,12,"0.0291366",1,"-1.13503","-0.0919601","sp|Q96EC8|YIPF6_HUMAN;tr|B1AV70|B1AV70_HUMAN","sp|Q96EC8|YIPF6_HUMAN",3660,"Q96EC8","YIPF6_HUMAN","Protein YIPF6",null,"YIPF6"]
["16.8052","13.8411","17.339","15.6182",{"$nulls":3},"androgen receptor signaling pathway;intracellular steroid hormone receptor signaling pathway;positive regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","catalytic activity;receptor activity;thyroid hormone receptor binding;thyroid hormone receptor coactivator activity;transcription coactivator activity;transcription cofactor activity;vitamin D receptor binding","mediator complex;membrane;nucleoplasm;nucleus","Thyroid hormone signaling pathway",null,null,8,8,8,"11.1","11.1","11.1","96.792",0,"26.657",202450000,23,"0.244386",1,"-1.15543","-0.674222","sp|Q9Y2X0|MED16_HUMAN;tr|K7EKS6|K7EKS6_HUMAN;tr|U3KQ43|U3KQ43_HUMAN;tr|U3KQB4|U3KQB4_HUMAN;tr|B9TWZ6|B9TWZ6_HUMAN;tr|A0A0J9YYC6|A0A0J9YYC6_HUMAN;tr|A0A0J9YXE6|A0A0J9YXE6_HUMAN;tr|A0A0J9YXA0|A0A0J9YXA0_HUMAN;tr|B9TX03|B9TX03_HUMAN;tr|A0A0J9YXK9|A0A0J9YXK9_HUMAN;tr|A0A0J9YXL6|A0A0J9YXL6_HUMAN;tr|A0A0J9YW49|A0A0J9YW49_HUMAN;tr|A0A0J9YXE7|A0A0J9YXE7_HUMAN;tr|A0A0J9YY02|A0A0J9YY02_HUMAN;tr|B9TX12|B9TX12_HUMAN;tr|B9TX11|B9TX11_HUMAN","sp|Q9Y2X0|MED16_HUMAN;tr|K7EKS6|K7EKS6_HUMAN;tr|U3KQ43|U3KQ43_HUMAN;tr|U3KQB4|U3KQB4_HUMAN;tr|B9TWZ6|B9TWZ6_HUMAN",4946,"Q9Y2X0","MED16_HUMAN","Mediator of RNA polymerase II transcription subunit 16",null,"MED16"]
["17.8918","16.9164","19.5057","17.687",{"$nulls":3},"mRNA splicing, via spliceosome;protein folding","peptidyl-prolyl cis-trans isomerase activity","catalytic step 2 spliceosome;nucleoplasm",{"$nulls":3},5,5,5,"17.4","17.4","17.4","53.846","0.00024552","5.9284",44422000,5,"0.434959",1,"-1.19225","-1.15539","sp|Q6UX04|CWC27_HUMAN;tr|D6REK3|D6REK3_HUMAN","sp|Q6UX04|CWC27_HUMAN;tr|D6REK3|D6REK3_HUMAN",2908,"Q6UX04","CWC27_HUMAN","Peptidyl-prolyl cis-trans isomerase CWC27 homolog","PIase CWC27","CWC27"]
["18.9968","17.2569","19.6587","18.9894",{"$nulls":4},"transmembrane transporter activity","integral component of membrane",{"$nulls":3},2,2,2,11,11,11,"41.211","0.00023998","5.4988",64893000,3,"0.484547",1,"-1.19718","-1.28441","sp|Q8IXU6|S35F2_HUMAN;tr|E9PKZ2|E9PKZ2_HUMAN;tr|E9PRY2|E9PRY2_HUMAN;tr|E9PJD1|E9PJD1_HUMAN","sp|Q8IXU6|S35F2_HUMAN;tr|E9PKZ2|E9PKZ2_HUMAN;tr|E9PRY2|E9PRY2_HUMAN;tr|E9PJD1|E9PJD1_HUMAN",3151,"Q8IXU6","S35F2_HUMAN","Solute carrier family 35 member F2",null,"SLC35F2"]
["19.4925","16.9644","20.31","18.6203",{"$nulls":3},"cognition;magnesium ion transport;neutrophil degranulation;protein N-linked glycosylation;protein N-linked glycosylation via asparagine;transmembrane transport","magnesium ion transmembrane transporter activity","azurophil granule membrane;endoplasmic reticulum;integral component of plasma membrane;membrane;oligosaccharyltransferase complex;plasma membrane",{"$nulls":3},10,10,10,"26.6","26.6","26.6","38.036",0,"30.233",1224700000,70,"0.299789",1,"-1.23666","-0.813385","sp|Q9H0U3|MAGT1_HUMAN;tr|A0A087WU53|A0A087WU53_HUMAN","sp|Q9H0U3|MAGT1_HUMAN;tr|A0A087WU53|A0A087WU53_HUMAN",4144,"Q9H0U3","MAGT1_HUMAN","Magnesium transporter protein 1","agT1","MAGT1"]
["14.1524","14.0741","15.5535","15.1572",{"$nulls":3},"chondrocyte differentiation involved in endochondral bone morphogenesis;Golgi organization;inner ear receptor stereocilium organization;intraciliary transport involved in cilium assembly;protein glycosylation;transcription from RNA polymerase II promoter;ventricular septum development","transcription coactivator activity","cilium;cis-Golgi network;cytoskeleton;Golgi apparatus;Golgi membrane;inner acrosomal membrane;nuclear speck;nucleus;outer acrosomal membrane;transport vesicle",{"$nulls":3},4,4,4,"2.7","2.7","2.7","227.58",0,"13.433",43198000,12,"1.59449",1,"-1.24209","-6.14939","sp|Q15643|TRIPB_HUMAN;tr|H0YJ97|H0YJ97_HUMAN","sp|Q15643|TRIPB_HUMAN;tr|H0YJ97|H0YJ97_HUMAN",2507,"Q15643","TRIPB_HUMAN","Thyroid receptor-interacting protein 11","R-interacting protein 11;RIP-11","TRIP11"]
["19.2283","19.3325","21.3793","19.6773",{"$nulls":3},"activation of phospholipase A2 activity by calcium-mediated signaling;activation of phospholipase C activity;astrocyte activation;cell proliferation;cell surface receptor signaling pathway;cell-cell adhesion;cellular response to amino acid stimulus;cellular response to cadmium ion;cellular response to dexamethasone stimulus;cellular response to drug;cellular response to epidermal growth factor stimulus;cellular response to estradiol stimulus;cellular response to mechanical stimulus;cellular response to reactive oxygen species;cerebral cortex cell migration;circadian rhythm;digestive tract morphogenesis;diterpenoid metabolic process;embryonic placenta development;epidermal growth factor receptor signaling pathway;ERBB2 signaling pathway;eyelid development in camera-type eye;hair follicle development;hydrogen peroxide metabolic process;learning or memory;liver regeneration;lung development;magnesium ion homeostasis;MAPK cascade;membrane organization;midgut development;morphogenesis of an epithelial fold;negative regulation of apoptotic process;negative regulation of cardiocyte differentiation;negative regulation of epidermal growth factor receptor signaling pathway;negative regulation of ERBB signaling pathway;negative regulation of mitotic cell cycle;negative regulation of protein catabolic process;neuron projection morphogenesis;ossification;ovulation cycle;peptidyl-tyrosine autophosphorylation;peptidyl-tyrosine phosphorylation;positive regulation of blood vessel diameter;positive regulation of bone resorption;positive regulation of catenin import into nucleus;positive regulation of cell growth;positive regulation of cell migration;positive regulation of cell proliferation;positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;positive regulation of DNA repair;positive regulation of DNA replication;positive regulation of epithelial cell proliferation;positive regulation of ERK1 and ERK2 cascade;positive regulation of fibroblast proliferation;positive regulation of inflammatory response;positive regulation of MAP kinase activity;positive regulation of NIK/NF-kappaB signaling;positive regulation of nitric oxide biosynthetic process;positive regulation of peptidyl-serine phosphorylation;positive regulation of phosphorylation;positive regulation of production of miRNAs involved in gene silencing by miRNA;positive regulation of prolactin secretion;positive regulation of protein kinase B signaling;positive regulation of protein kinase C activity;positive regulation of protein localization to plasma membrane;positive regulation of protein phosphorylation;positive regulation of smooth muscle cell proliferation;positive regulation of superoxide anion generation;positive regulation of synaptic transmission, glutamatergic;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;positive regulation of vasoconstriction;protein autophosphorylation;protein insertion into membrane;regulation of cell motility;regulation of ERK1 and ERK2 cascade;regulation of JNK cascade;regulation of nitric-oxide synthase activity;regulation of peptidyl-tyrosine phosphorylation;regulation of phosphatidylinositol 3-kinase signaling;regulation of transcription from RNA polymerase II promoter;response to calcium ion;response to cobalamin;response to hydroxyisoflavone;response to osmotic stress;response to stress;response to UV-A;salivary gland morphogenesis;signal transduction;tongue development;translation;wound healing","actin filament binding;ATP binding;cadherin binding;calmodulin binding;chromatin binding;double-stranded DNA binding;enzyme binding;epidermal growth factor binding;epidermal growth factor-activated receptor activity;identical protein binding;integrin binding;MAP kinase kinase kinase activity;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;protein heterodimerization activity;protein kinase binding;protein phosphatase binding;protein tyrosine kinase activity;Ras guanyl-nucleotide exchange factor activity;signal transducer, downstream of receptor, with protein tyrosine kinase activity;transmembrane receptor protein tyrosine kinase activity;transmembrane signaling receptor activity;ubiquitin protein ligase binding;virus receptor activity","apical plasma membrane;basolateral plasma membrane;cell surface;clathrin-coated vesicle membrane;cytoplasm;early endosome membrane;endocytic vesicle;endoplasmic reticulum membrane;endosome;endosome membrane;extracellular space;focal adhesion;Golgi membrane;integral component of membrane;membrane;membrane raft;multivesicular body, internal vesicle lumen;nuclear membrane;nucleus;perinuclear region of cytoplasm;plasma membrane;protein complex;receptor complex;Shc-EGFR complex;synapse","Adherens junction;Bladder cancer;Breast cancer;Calcium signaling pathway;Central carbon metabolism in cancer;Choline metabolism in cancer;Colorectal cancer;Cushing syndrome;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Endocytosis;Endometrial cancer;Epithelial cell signaling in Helicobacter pylori infection;ErbB signaling pathway;Estrogen signaling pathway;Focal adhesion;FoxO signaling pathway;Gap junction;Gastric cancer;Glioma;GnRH signaling pathway;Hepatitis C;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Jak-STAT signaling pathway;MAPK signaling pathway;Melanoma;MicroRNAs in cancer;Non-small cell lung cancer;Oxytocin signaling pathway;Pancreatic cancer;Parathyroid hormone synthesis, secretion and action;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway",null,null,13,13,12,"14.2","14.2","13.2","134.28",0,"38.477",847160000,46,"0.551535",1,"-1.2479","-1.46369","sp|P00533|EGFR_HUMAN;tr|E9PFD7|E9PFD7_HUMAN;tr|Q504U8|Q504U8_HUMAN;tr|A0A0B4J1Y5|A0A0B4J1Y5_HUMAN;tr|C9JYS6|C9JYS6_HUMAN;tr|J3KTI5|J3KTI5_HUMAN;tr|H3BLT0|H3BLT0_HUMAN;tr|A0A0A0MSE1|A0A0A0MSE1_HUMAN;sp|Q15303|ERBB4_HUMAN","sp|P00533|EGFR_HUMAN;tr|E9PFD7|E9PFD7_HUMAN;tr|Q504U8|Q504U8_HUMAN",805,"P00533","EGFR_HUMAN","Epidermal growth factor receptor",null,"EGFR"]
["15.7922",1,"18.2973",1,{"$nulls":3},"translation","GTP binding;GTPase activity","mitochondrial inner membrane",{"$nulls":3},8,8,8,"17.5","17.5","17.5","74.327",0,"29.052",186640000,26,"0.0350784",1,"-1.25256","-0.110068","sp|Q8N442|GUF1_HUMAN","sp|Q8N442|GUF1_HUMAN",3221,"Q8N442","GUF1_HUMAN","Translation factor GUF1, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03137}",null,"GUF1"]
["21.4987","19.1998","21.8105","21.4783",{"$nulls":3},"negative regulation of nucleic acid-templated transcription;neuron differentiation;positive regulation of transcription, DNA-templated","identical protein binding;transcription factor binding","cytoplasm;mitochondrion;nucleus",{"$nulls":3},5,5,5,"18.6","18.6","18.6","41.968",0,"23.755",385360000,21,"0.419307",1,"-1.29515","-1.1152","sp|Q9GZT8|NIF3L_HUMAN;tr|E7EXA3|E7EXA3_HUMAN;tr|Q6X734|Q6X734_HUMAN;tr|B8ZZI0|B8ZZI0_HUMAN;tr|C9JN42|C9JN42_HUMAN","sp|Q9GZT8|NIF3L_HUMAN;tr|E7EXA3|E7EXA3_HUMAN;tr|Q6X734|Q6X734_HUMAN;tr|B8ZZI0|B8ZZI0_HUMAN",4118,"Q9GZT8","NIF3L_HUMAN","NIF3-like protein 1 {ECO:0000305|PubMed:11124544}",null,"NIF3L1"]
["16.8805","17.8709","17.8988","19.4783",{"$nulls":3},"DNA replication","3'-5' exonuclease activity;4 iron, 4 sulfur cluster binding;DNA binding;DNA-directed DNA polymerase activity;metal ion binding;nucleoside binding;nucleotide binding","cytosol;nucleoplasm",{"$nulls":3},11,11,11,"10.7","10.7","10.7","165.77",0,"29.539",505700000,25,"0.531155",1,"-1.31289","-1.40846","tr|A0A087WU64|A0A087WU64_HUMAN;sp|P09884|DPOLA_HUMAN;tr|A6NMQ1|A6NMQ1_HUMAN","tr|A0A087WU64|A0A087WU64_HUMAN;sp|P09884|DPOLA_HUMAN;tr|A6NMQ1|A6NMQ1_HUMAN",956,"A0A087WU64","A0A087WU64_HUMAN","DNA polymerase {ECO:0000256|RuleBase:RU000442}",null,"POLA1"]
["21.3943","18.7525","21.7158","21.0744",{"$nulls":3},"vesicle-mediated transport",null,"integral component of membrane",{"$nulls":3},2,2,2,"20.3","20.3","20.3","8.2139","0.00069316","4.7159",66241000,1,"0.36307",1,"-1.32167","-0.972348","tr|G3V1U5|G3V1U5_HUMAN;tr|F5H6U7|F5H6U7_HUMAN;sp|Q9Y3E0|GOT1B_HUMAN","tr|G3V1U5|G3V1U5_HUMAN;tr|F5H6U7|F5H6U7_HUMAN;sp|Q9Y3E0|GOT1B_HUMAN",4987,"G3V1U5","G3V1U5_HUMAN"]
[1,"14.1664",1,"16.8595",{"$nulls":3},"intracellular signal transduction","ATP binding;protein serine/threonine kinase activity","intracellular",{"$nulls":3},2,2,2,"1.2","1.2","1.2","187.3","0.0006772","4.2995",19799000,3,"0.0419115",1,"-1.34656","-0.130654","tr|H7BYJ3|H7BYJ3_HUMAN;sp|O14578|CTRO_HUMAN","tr|H7BYJ3|H7BYJ3_HUMAN;sp|O14578|CTRO_HUMAN",262,"H7BYJ3","H7BYJ3_HUMAN",null,null,"CIT"]
["15.0299","17.2738","17.0446","17.9678",{"$nulls":5},"nucleus",{"$nulls":3},6,6,6,"18.6","18.6","18.6","54.813",0,"44.381",191590000,33,"0.419772",1,"-1.35437","-1.11639","sp|Q12894|IFRD2_HUMAN;tr|H7C444|H7C444_HUMAN;tr|H7C2Z4|H7C2Z4_HUMAN;tr|F8WEI6|F8WEI6_HUMAN","sp|Q12894|IFRD2_HUMAN;tr|H7C444|H7C444_HUMAN",2173,"Q12894","IFRD2_HUMAN","Interferon-related developmental regulator 2",null,"IFRD2"]
["13.4596",1,"16.2099",1,{"$nulls":3},"snRNA processing;snRNA transcription from RNA polymerase II promoter;U2 snRNA 3'-end processing",null,"integral component of membrane;integrator complex;membrane;nuclear membrane;nucleoplasm",{"$nulls":3},8,8,8,"6.5","6.5","6.5","244.29",0,"24.417",173570000,12,"0.0450008",1,"-1.37515","-0.139881","sp|Q8N201|INT1_HUMAN","sp|Q8N201|INT1_HUMAN",3205,"Q8N201","INT1_HUMAN","Integrator complex subunit 1","nt1","INTS1"]
["16.1052",1,"18.913",1,{"$nulls":9},1,1,1,"10.2","10.2","10.2","13.847","0.0029252","3.2349",50221000,4,"0.0383079",1,"-1.40389","-0.119828","tr|A6NCC9|A6NCC9_HUMAN;tr|E9PME3|E9PME3_HUMAN;tr|C9JHT9|C9JHT9_HUMAN;tr|C9JJV1|C9JJV1_HUMAN;sp|Q9Y5U2|TSSC4_HUMAN","tr|A6NCC9|A6NCC9_HUMAN;tr|E9PME3|E9PME3_HUMAN;tr|C9JHT9|C9JHT9_HUMAN;tr|C9JJV1|C9JJV1_HUMAN;sp|Q9Y5U2|TSSC4_HUMAN",5057,"A6NCC9","A6NCC9_HUMAN",null,null,"TSSC4"]
["14.3269","14.5893","14.706","17.0323",{"$nulls":3},"cellular calcium ion homeostasis","ATP binding;calcium-transporting ATPase activity;metal ion binding","integral component of plasma membrane;intracellular membrane-bounded organelle;membrane",{"$nulls":3},2,2,2,"1.7","1.7","1.7","138.04","0.0037229","3.0952",15241000,2,"0.454316",1,"-1.41102","-1.20543","sp|Q9H7F0|AT133_HUMAN;tr|A0A087WYY3|A0A087WYY3_HUMAN","sp|Q9H7F0|AT133_HUMAN;tr|A0A087WYY3|A0A087WYY3_HUMAN",4244,"Q9H7F0","AT133_HUMAN","Probable cation-transporting ATPase 13A3",null,"ATP13A3"]
["16.5264","17.2528","18.6544","18.0286",{"$nulls":3},"intracellular protein transport","SNAP receptor activity","intracellular;membrane",{"$nulls":3},4,4,4,"18.5","18.5","18.5","35.42",0,"10.837",66789000,14,"1.02728",1,"-1.45191","-3.0287","tr|D6RF48|D6RF48_HUMAN;sp|Q9P2W9|STX18_HUMAN;tr|D6RC71|D6RC71_HUMAN","tr|D6RF48|D6RF48_HUMAN;sp|Q9P2W9|STX18_HUMAN;tr|D6RC71|D6RC71_HUMAN",4651,"D6RF48","D6RF48_HUMAN",null,null,"STX18"]
["15.3204","14.6502","16.8124","16.0831",{"$nulls":3},"actin cytoskeleton reorganization;actomyosin structure organization;cell migration;cytoskeleton organization;establishment or maintenance of cell polarity;intracellular signal transduction;protein phosphorylation;signal transduction","ATP binding;magnesium ion binding;protein kinase activity;protein serine/threonine kinase activity;Rho GTPase binding","actomyosin;cell leading edge;cell-cell junction;cytoplasm;cytoskeleton;extracellular exosome;lamellipodium;plasma membrane",{"$nulls":3},12,7,7,"8.5","5.6","5.6","194.31",0,"25.803",209290000,33,"1.00834",1,"-1.46246","-2.95291","sp|Q9Y5S2|MRCKB_HUMAN;tr|H0YLY0|H0YLY0_HUMAN","sp|Q9Y5S2|MRCKB_HUMAN;tr|H0YLY0|H0YLY0_HUMAN",5053,"Q9Y5S2","MRCKB_HUMAN","Serine/threonine-protein kinase MRCK beta",null,"CDC42BPB"]
["21.0062","20.2801","21.6145","22.6165",{"$nulls":3},"calcineurin-NFAT signaling cascade;calcium ion transport;cardiac muscle hypertrophy in response to stress;cellular response to drug;cellular response to glucose stimulus;dephosphorylation;excitatory postsynaptic potential;Fc-epsilon receptor signaling pathway;G1/S transition of mitotic cell cycle;modulation of chemical synaptic transmission;multicellular organismal response to stress;negative regulation of chromatin binding;negative regulation of dendrite morphogenesis;negative regulation of insulin secretion;negative regulation of production of miRNAs involved in gene silencing by miRNA;positive regulation of cardiac muscle hypertrophy in response to stress;positive regulation of connective tissue replacement;positive regulation of DNA binding transcription factor activity;positive regulation of endocytosis;positive regulation of NFAT protein import into nucleus;positive regulation of transcription from RNA polymerase II promoter;protein dephosphorylation;protein import into nucleus;response to amphetamine;response to calcium ion;skeletal muscle fiber development;T cell activation;transition between fast and slow fiber;Wnt signaling pathway, calcium modulating pathway","calcium ion binding;calmodulin binding;calmodulin-dependent protein phosphatase activity;cyclosporin A binding;drug binding;enzyme binding;protein dimerization activity;protein heterodimerization activity;protein serine/threonine phosphatase activity","calcineurin complex;cytosol;mitochondrion;nucleoplasm;postsynapse;sarcolemma;Z disc","Alzheimer disease;Amphetamine addiction;Amyotrophic lateral sclerosis (ALS);Axon guidance;B cell receptor signaling pathway;Calcium signaling pathway;Cellular senescence;cGMP-PKG signaling pathway;C-type lectin receptor signaling pathway;Dopaminergic synapse;Glucagon signaling pathway;Glutamatergic synapse;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human T-cell leukemia virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Long-term potentiation;MAPK signaling pathway;Natural killer cell mediated cytotoxicity;Oocyte meiosis;Osteoclast differentiation;Oxytocin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;Renin secretion;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Tuberculosis;VEGF signaling pathway;Wnt signaling pathway",null,null,11,11,10,"23.2","23.2","21.5","58.687",0,"29.127",522750000,34,"0.852793",1,"-1.47234","-2.37968","sp|Q08209|PP2BA_HUMAN;tr|E7ETC2|E7ETC2_HUMAN;tr|Q5F2F8|Q5F2F8_HUMAN;sp|P16298|PP2BB_HUMAN;tr|E9PPC8|E9PPC8_HUMAN;tr|E9PK68|E9PK68_HUMAN;tr|Q5F2G0|Q5F2G0_HUMAN;tr|H0YC26|H0YC26_HUMAN","sp|Q08209|PP2BA_HUMAN;tr|E7ETC2|E7ETC2_HUMAN;tr|Q5F2F8|Q5F2F8_HUMAN;sp|P16298|PP2BB_HUMAN",2125,"Q08209","PP2BA_HUMAN","Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform",null,"PPP3CA"]
["16.8775","15.4286","16.5933","18.7306",{"$nulls":3},"chromatin remodeling;covalent chromatin modification;mitotic cell cycle;negative regulation of cell proliferation;regulation of transcription, DNA-templated;transcription, DNA-templated","chromatin binding;DNA binding","nuclear chromosome;nucleoplasm;RSC-type complex","Hepatocellular carcinoma",null,null,40,40,40,"31.9","31.9","31.9","192.95",0,"133.77",1507300000,180,"0.440148",1,"-1.50895","-1.16877","sp|Q86U86|PB1_HUMAN;tr|E7EVG2|E7EVG2_HUMAN;tr|H0Y5B5|H0Y5B5_HUMAN;tr|C9JPI5|C9JPI5_HUMAN;tr|C9JQF1|C9JQF1_HUMAN;tr|C9J409|C9J409_HUMAN;tr|C9JCJ2|C9JCJ2_HUMAN;tr|C9J053|C9J053_HUMAN","sp|Q86U86|PB1_HUMAN;tr|E7EVG2|E7EVG2_HUMAN;tr|H0Y5B5|H0Y5B5_HUMAN",3043,"Q86U86","PB1_HUMAN","Protein polybromo-1","PB1","PBRM1"]
["19.3191","17.9558","20.19","20.2473",{"$nulls":3},"axonogenesis;brain morphogenesis;cell-cell adhesion;dendrite morphogenesis;positive regulation of muscle cell differentiation;prepulse inhibition;radial glia guided migration of Purkinje cell;regulation of synapse structural plasticity","actin filament binding;cadherin binding;identical protein binding;structural constituent of cytoskeleton","actin cytoskeleton;adherens junction;axon;basolateral plasma membrane;cell-cell adherens junction;cytoplasm;cytosol;lamellipodium;nucleus;postsynaptic density","Adherens junction;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Bacterial invasion of epithelial cells;Endometrial cancer;Gastric cancer;Hippo signaling pathway;Leukocyte transendothelial migration;Pathways in cancer",null,null,7,1,1,10,"1.9","1.9","105.31",0,"41.657",324610000,11,"0.834556",1,"-1.58122","-2.31767","sp|P26232|CTNA2_HUMAN;tr|C9IZ88|C9IZ88_HUMAN;tr|C9J144|C9J144_HUMAN","sp|P26232|CTNA2_HUMAN",1236,"P26232","CTNA2_HUMAN","Catenin alpha-2",null,"CTNNA2"]
["18.7708","19.5245","21.2955","20.3053",{"$nulls":3},"autophagosome assembly;autophagosome maturation;autophagy;autophagy of mitochondrion;cellular response to nitrogen starvation;intra-Golgi vesicle-mediated transport;macroautophagy;negative regulation of proteasomal protein catabolic process;positive regulation of ATPase activity;protein transport","ATPase binding;beta-tubulin binding;GABA receptor binding;microtubule binding;SNARE binding;ubiquitin protein ligase binding","autophagosome;autophagosome membrane;cytoplasm;cytoplasmic vesicle;cytosol;Golgi apparatus;Golgi membrane;intracellular","Apelin signaling pathway;Autophagy - animal;Autophagy - other;FoxO signaling pathway;GABAergic synapse;Kaposi sarcoma-associated herpesvirus infection;Mitophagy - animal;NOD-like receptor signaling pathway",null,null,4,4,4,35,35,35,"13.667","0.00024697","6.1439",79393000,16,"0.930712",1,"-1.65275","-2.65641","sp|P60520|GBRL2_HUMAN;tr|H3BSM5|H3BSM5_HUMAN;tr|H3BQ50|H3BQ50_HUMAN;tr|F5GZY7|F5GZY7_HUMAN;tr|H6UMI1|H6UMI1_HUMAN;sp|Q9H0R8|GBRL1_HUMAN;sp|O95166|GBRAP_HUMAN","sp|P60520|GBRL2_HUMAN;tr|H3BSM5|H3BSM5_HUMAN;tr|H3BQ50|H3BQ50_HUMAN",1809,"P60520","GBRL2_HUMAN","Gamma-aminobutyric acid receptor-associated protein-like 2",null,"GABARAPL2"]
["14.0762","12.8625","14.0701","16.1974",{"$nulls":3},"exocytosis;intracellular protein transport;negative regulation of phosphatase activity;positive regulation of mucus secretion;protein localization to plasma membrane;vesicle docking involved in exocytosis;vesicle fusion;vesicle-mediated transport","calcium ion binding;calcium-dependent phospholipid binding;clathrin binding;neurexin family protein binding;phosphatase binding;phosphatidylinositol-4,5-bisphosphate binding;phosphatidylserine binding;Rab GTPase binding;syntaxin binding","cytoplasm;exocytic vesicle;extrinsic component of plasma membrane;melanosome;membrane;plasma membrane",{"$nulls":3},13,13,13,"21.4","21.4","21.4","104.93",0,"43.281",307750000,51,"0.512764",1,"-1.66444","-1.35915","sp|Q9HCH5|SYTL2_HUMAN;tr|E9PS29|E9PS29_HUMAN;tr|E9PS39|E9PS39_HUMAN;tr|E9PK22|E9PK22_HUMAN;tr|E9PRW5|E9PRW5_HUMAN;tr|E9PQL8|E9PQL8_HUMAN;tr|E9PPL3|E9PPL3_HUMAN","sp|Q9HCH5|SYTL2_HUMAN",4328,"Q9HCH5","SYTL2_HUMAN","Synaptotagmin-like protein 2",null,"SYTL2"]
["16.2174","18.9651","16.7399","21.8908",{"$nulls":3},"cell cycle;cell division;nervous system development;regulation of cell cycle",null,"cytosol;nucleus",{"$nulls":3},6,6,6,"15.2","15.2","15.2","67.598",0,"21.09",347620000,31,"0.211406",1,"-1.72412","-0.590662","sp|Q8TDN4|CABL1_HUMAN;tr|V9GYB4|V9GYB4_HUMAN","sp|Q8TDN4|CABL1_HUMAN",3386,"Q8TDN4","CABL1_HUMAN","CDK5 and ABL1 enzyme substrate 1",null,"CABLES1"]
["13.7184","15.7492","16.4345","16.5103",{"$nulls":3},"histone H3-K36 demethylation;negative regulation of histone H3-K9 trimethylation","histone demethylase activity (H3-K9 specific);metal ion binding","cytosol;nuclear pericentric heterochromatin;nucleus",{"$nulls":3},4,4,4,"6.8","6.8","6.8","121.9",0,"12.516",105950000,19,"0.639803",1,"-1.73861","-1.71111","tr|A0A0C4DFL8|A0A0C4DFL8_HUMAN;sp|O94953|KDM4B_HUMAN;tr|F5GX28|F5GX28_HUMAN;tr|K7EQ54|K7EQ54_HUMAN","tr|A0A0C4DFL8|A0A0C4DFL8_HUMAN;sp|O94953|KDM4B_HUMAN;tr|F5GX28|F5GX28_HUMAN;tr|K7EQ54|K7EQ54_HUMAN",677,"A0A0C4DFL8","A0A0C4DFL8_HUMAN",null,null,"KDM4B"]
["15.2083","22.1086","20.5153","20.2857",{"$nulls":4},"4 iron, 4 sulfur cluster binding;metal ion binding;NADH dehydrogenase (ubiquinone) activity;quinone binding",{"$nulls":4},4,4,4,"21.4","21.4","21.4","19.77",0,"22.25",206550000,21,"0.177884",1,"-1.74203","-0.50464","tr|F5H5N1|F5H5N1_HUMAN;sp|O75251|NDUS7_HUMAN;tr|F5GXJ1|F5GXJ1_HUMAN;tr|A0A087WXF6|A0A087WXF6_HUMAN;tr|A0A087WTI3|A0A087WTI3_HUMAN","tr|F5H5N1|F5H5N1_HUMAN;sp|O75251|NDUS7_HUMAN;tr|F5GXJ1|F5GXJ1_HUMAN;tr|A0A087WXF6|A0A087WXF6_HUMAN;tr|A0A087WTI3|A0A087WTI3_HUMAN",541,"F5H5N1","F5H5N1_HUMAN",null,null,"NDUFS7"]
["19.3415","14.669","18.8167","18.6835",{"$nulls":3},"ammonia assimilation cycle;cell proliferation;cellular amino acid biosynthetic process;cellular response to starvation;glutamate catabolic process;glutamine biosynthetic process;neurotransmitter uptake;positive regulation of epithelial cell proliferation;positive regulation of insulin secretion;positive regulation of synaptic transmission, glutamatergic;protein homooligomerization;response to glucose","ATP binding;dynein light chain binding;glutamate binding;glutamate decarboxylase activity;glutamate-ammonia ligase activity;identical protein binding;magnesium ion binding;manganese ion binding","axon terminus;cytosol;extracellular exosome;glial cell projection;mitochondrion;myelin sheath;nucleus;perikaryon;protein complex;rough endoplasmic reticulum","Alanine, aspartate and glutamate metabolism;Arginine biosynthesis;Biosynthesis of amino acids;GABAergic synapse;Glutamatergic synapse;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Necroptosis;Nitrogen metabolism",null,null,7,7,7,"21.7","21.7","21.7","42.064",0,"14.121",84423000,8,"0.273142",1,"-1.74485","-0.746555","sp|P15104|GLNA_HUMAN;tr|A0A087WYJ1|A0A087WYJ1_HUMAN","sp|P15104|GLNA_HUMAN",1056,"P15104","GLNA_HUMAN","Glutamine synthetase","S","GLUL"]
["12.9795",1,"16.4849",1,{"$nulls":3},"cellular response to angiotensin;chromatin-mediated maintenance of transcription;covalent chromatin modification;dendritic cell dendrite assembly;dendritic spine development;neuron-neuron synaptic transmission;response to ischemia;transcription, DNA-templated","DNA binding;transcription coactivator activity","cytosol;nBAF complex;nucleoplasm;plasma membrane;SWI/SNF complex","Hepatocellular carcinoma;Thermogenesis",null,null,19,16,16,"12.1","10.3","10.3","236.12",0,"60.812",376890000,62,"0.0582917",1,"-1.75269","-0.179049","sp|Q8NFD5|ARI1B_HUMAN;tr|H0Y7H8|H0Y7H8_HUMAN;tr|H0Y2R3|H0Y2R3_HUMAN;tr|H0Y3S9|H0Y3S9_HUMAN;tr|A0A0J9YY80|A0A0J9YY80_HUMAN","sp|Q8NFD5|ARI1B_HUMAN;tr|H0Y7H8|H0Y7H8_HUMAN",3336,"Q8NFD5","ARI1B_HUMAN","AT-rich interactive domain-containing protein 1B","RID domain-containing protein 1B","ARID1B"]
["19.1963","16.2472","19.7573","19.1948",{"$nulls":4},"methyltransferase activity",{"$nulls":4},3,3,3,"15.2","15.2","15.2","27.775",0,"31.729",134690000,10,"0.440106",1,"-1.75429","-1.16866","sp|Q6UX53|MET7B_HUMAN;tr|A0A087WZT2|A0A087WZT2_HUMAN","sp|Q6UX53|MET7B_HUMAN;tr|A0A087WZT2|A0A087WZT2_HUMAN",2910,"Q6UX53","MET7B_HUMAN","Methyltransferase-like protein 7B",null,"METTL7B"]
["16.0172","15.5097","18.4632","16.7655",{"$nulls":3},"apoptotic process;cell cycle arrest;cell growth;cellular protein localization;cellular response to amino acid starvation;cellular response to amino acid stimulus;positive regulation of TOR signaling;regulation of autophagy;regulation of macroautophagy;regulation of TOR signaling;regulation of TORC1 signaling;response to amino acid;RNA splicing;small GTPase mediated signal transduction;transcription, DNA-templated","GDP binding;GTP binding;GTPase activity;GTPase binding;magnesium ion binding;protein heterodimerization activity","cytoplasm;cytosol;EGO complex;Gtr1-Gtr2 GTPase complex;intracellular membrane-bounded organelle;lysosome;nucleus","Autophagy - animal;mTOR signaling pathway",null,null,2,2,2,"5.8","5.8","5.8","44.223","0.003538","3.1671",80348000,1,"0.764741",1,"-1.85095","-2.08916","sp|Q9HB90|RRAGC_HUMAN;sp|Q9NQL2|RRAGD_HUMAN","sp|Q9HB90|RRAGC_HUMAN;sp|Q9NQL2|RRAGD_HUMAN",4306,"Q9HB90","RRAGC_HUMAN","Ras-related GTP-binding protein C","ag C;agC","RRAGC"]
["15.1856","12.0387","15.5757","15.3881",{"$nulls":5},"cytoskeleton",{"$nulls":3},4,4,4,"2.6","2.6","2.6","204.49",0,"8.01",33689000,8,"0.446896",1,"-1.86973","-1.18621","tr|K7EKI8|K7EKI8_HUMAN;sp|O60437|PEPL_HUMAN;tr|K7EQ71|K7EQ71_HUMAN","tr|K7EKI8|K7EKI8_HUMAN;sp|O60437|PEPL_HUMAN;tr|K7EQ71|K7EQ71_HUMAN",471,"K7EKI8","K7EKI8_HUMAN",null,null,"PPL"]
["19.4558","16.1064","19.811","19.5241",{"$nulls":3},"cell proliferation;cellular response to cytokine stimulus;DNA repair;negative regulation of cell cycle arrest;negative regulation of mRNA polyadenylation;phosphorylation of RNA polymerase II C-terminal domain;positive regulation of cardiac muscle hypertrophy;positive regulation of histone H2B ubiquitination;positive regulation of histone phosphorylation;positive regulation of mRNA 3'-UTR binding;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral transcription;protein phosphorylation;regulation of DNA repair;regulation of histone modification;regulation of muscle cell differentiation;replication fork processing;response to drug;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","7SK snRNA binding;ATP binding;chromatin binding;cyclin binding;cyclin-dependent protein serine/threonine kinase activity;DNA binding;kinase activity;protein kinase activity;protein kinase binding;protein serine/threonine kinase activity;RNA polymerase II carboxy-terminal domain kinase activity;RNA polymerase II core promoter sequence-specific DNA binding;transcription coactivator binding;transcription regulatory region DNA binding","chromosome;cyclin/CDK positive transcription elongation factor complex;cytoplasmic ribonucleoprotein granule;membrane;nucleoplasm;PML body;transcription elongation factor complex","Transcriptional misregulation in cancer",null,null,12,11,11,36,"33.9","33.9","42.777",0,"83.119",522190000,39,"0.422099",1,"-1.88647","-1.12235","sp|P50750|CDK9_HUMAN;tr|X6RE90|X6RE90_HUMAN","sp|P50750|CDK9_HUMAN",1635,"P50750","CDK9_HUMAN","Cyclin-dependent kinase 9",null,"CDK9"]
["20.1762","15.8379","20.4053","19.3894",{"$nulls":3},"cell proliferation;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);Notch signaling pathway;ribosomal large subunit biogenesis;rRNA processing",null,"nucleolus;nucleoplasm;PeBoW complex;preribosome, large subunit precursor",{"$nulls":3},15,15,15,"48.5","48.5","48.5","47.707",0,"167.63",1774200000,136,"0.313789",1,"-1.89026","-0.848483","sp|Q9GZL7|WDR12_HUMAN","sp|Q9GZL7|WDR12_HUMAN",4106,"Q9GZL7","WDR12_HUMAN","Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}",null,"WDR12"]
["16.5975","16.104","16.4949","20.0228",{"$nulls":3},"cell division;mitotic cell cycle checkpoint;sister chromatid cohesion",null,"condensed chromosome kinetochore;cytosol;kinetochore;RZZ complex",{"$nulls":3},3,3,3,"5.6","5.6","5.6","67.213",0,"10.578",58680000,3,"0.402101",1,"-1.90808","-1.07125","sp|Q9H900|ZWILC_HUMAN;tr|H3BSG1|H3BSG1_HUMAN","sp|Q9H900|ZWILC_HUMAN",4264,"Q9H900","ZWILC_HUMAN","Protein zwilch homolog","Zwilch","ZWILCH"]
["16.9765","16.2867","18.6705","18.4429",{"$nulls":3},"ossification;positive regulation of interferon-alpha secretion;positive regulation of telomere maintenance;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;response to exogenous dsRNA;response to virus;RNA processing;RNA secondary structure unwinding;telomerase RNA stabilization;transcription, DNA-templated","ATP binding;ATP-dependent RNA helicase activity;core promoter binding;DNA-dependent ATPase activity;double-stranded RNA binding;G-quadruplex DNA binding;G-quadruplex RNA binding;histone deacetylase binding;RNA binding;single-stranded DNA binding;telomerase RNA binding;transcription regulatory region DNA binding","chromosome, telomeric region;cytoplasm;cytosol;extracellular exosome;nucleus","RNA degradation",null,null,8,8,8,"11.8","11.8","11.8","114.76",0,"16.686",139510000,9,"1.47116",1,"-1.92513","-5.30091","sp|Q9H2U1|DHX36_HUMAN;tr|E7EWK3|E7EWK3_HUMAN;tr|A0A0G2JRP3|A0A0G2JRP3_HUMAN;tr|H7C5F5|H7C5F5_HUMAN;tr|A0A0G2JQU7|A0A0G2JQU7_HUMAN","sp|Q9H2U1|DHX36_HUMAN;tr|E7EWK3|E7EWK3_HUMAN",4176,"Q9H2U1","DHX36_HUMAN","ATP-dependent RNA helicase DHX36",null,"DHX36"]
["18.9662","18.0377","19.5503","21.3744",{"$nulls":3},"protein folding","heat shock protein binding;metal ion binding;unfolded protein binding",{"$nulls":4},4,4,4,"23.7","23.7","23.7","24.377","0.00026638","7.7036",81249000,12,"0.708855",1,"-1.96039","-1.91554","tr|F5H170|F5H170_HUMAN;sp|Q8WW22|DNJA4_HUMAN;tr|C9JDE6|C9JDE6_HUMAN;tr|F8WF76|F8WF76_HUMAN","tr|F5H170|F5H170_HUMAN;sp|Q8WW22|DNJA4_HUMAN;tr|C9JDE6|C9JDE6_HUMAN;tr|F8WF76|F8WF76_HUMAN",3450,"F5H170","F5H170_HUMAN",null,null,"DNAJA4"]
["16.3186","15.7758","18.496","17.5211",{"$nulls":3},"chromosome segregation;covalent chromatin modification;DNA methylation;maintenance of DNA methylation;negative regulation of cell proliferation;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;nucleosome positioning;positive regulation of gene expression;positive regulation of transcription, DNA-templated;protein localization to chromosome, centromeric region;regulation of centromeric sister chromatid cohesion;regulation of gene expression by genetic imprinting;regulation of gene expression, epigenetic;regulation of histone acetylation;regulation of histone methylation;regulation of molecular function, epigenetic","chromatin insulator sequence binding;DNA binding transcription factor activity;RNA polymerase II proximal promoter sequence-specific DNA binding;sequence-specific DNA binding;transcription corepressor activity;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding;zinc ion binding","chromosome, centromeric region;condensed chromosome;nucleolus;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"8.3","8.3","8.3","82.785",0,"57.881",364170000,26,"1.1411",1,"-1.96134","-3.51534","sp|P49711|CTCF_HUMAN;tr|V9GY73|V9GY73_HUMAN;sp|Q8NI51|CTCFL_HUMAN","sp|P49711|CTCF_HUMAN",1589,"P49711","CTCF_HUMAN","Transcriptional repressor CTCF",null,"CTCF"]
[1,"12.6415",1,"16.6589",{"$nulls":3},"defense response to virus;innate immune response;positive regulation of innate immune response;positive regulation of interferon-beta production;positive regulation of type I interferon production;transcription from RNA polymerase III promoter","DNA binding;DNA-directed 5'-3' RNA polymerase activity;metal ion binding;ribonucleoside binding","cytosol;DNA-directed RNA polymerase III complex;nucleoplasm","Cytosolic DNA-sensing pathway;RNA polymerase",null,null,2,2,2,"2.9","2.9","2.9","127.78","0.00067144","4.1707",186770000,2,"0.0675597",1,"-2.00866","-0.205888","sp|Q9NW08|RPC2_HUMAN","sp|Q9NW08|RPC2_HUMAN",4508,"Q9NW08","RPC2_HUMAN","DNA-directed RNA polymerase III subunit RPC2","NA polymerase III subunit C2","POLR3B"]
["15.3812","16.2303","18.1881","17.4739",{"$nulls":3},"intracellular transport of virus;mitotic nuclear envelope disassembly;mRNA export from nucleus;nuclear pore complex assembly;nuclear pore distribution;protein sumoylation;protein transport;regulation of cellular response to heat;regulation of gene silencing by miRNA;regulation of glycolytic process;spermatogenesis;synapsis;tRNA export from nucleus;viral process;viral transcription","structural constituent of nuclear pore","actin cytoskeleton;cytoplasm;host cell;integral component of membrane;membrane;nuclear envelope;nuclear membrane;nuclear pore;nuclear pore transmembrane ring;plasma membrane","RNA transport",null,null,4,4,4,"9.3","9.3","9.3","76.304",0,"8.6134",95624000,15,"1.17057",1,"-2.02526","-3.65077","sp|Q9BTX1|NDC1_HUMAN","sp|Q9BTX1|NDC1_HUMAN",3974,"Q9BTX1","NDC1_HUMAN","Nucleoporin NDC1","NDC1","NDC1"]
["15.238","14.1588","16.9127","16.7157",{"$nulls":3},"activation of MAPKK activity;cell adhesion;cell adhesion mediated by integrin;cell migration;cell-cell adhesion mediated by integrin;cell-matrix adhesion;cellular response to lipopolysaccharide;integrin-mediated signaling pathway;keratinocyte differentiation;membrane protein ectodomain proteolysis;monocyte activation;PMA-inducible membrane protein ectodomain proteolysis;positive regulation of cell adhesion mediated by integrin;positive regulation of keratinocyte migration;positive regulation of macrophage fusion;positive regulation of membrane protein ectodomain proteolysis;positive regulation of protein secretion;response to calcium ion;response to glucocorticoid;response to hydrogen peroxide;response to laminar fluid shear stress;response to manganese ion;response to tumor necrosis factor;transforming growth factor beta receptor signaling pathway","collagen binding;integrin binding;laminin binding;metal ion binding;metalloendopeptidase activity;metallopeptidase activity;protein kinase C binding;SH3 domain binding","basolateral plasma membrane;cell surface;extracellular exosome;extracellular space;focal adhesion;integral component of membrane;intrinsic component of external side of plasma membrane",{"$nulls":3},3,3,3,"4.3","4.3","4.3","90.555","0.00025202","6.5237",53603000,8,"1.21386",1,"-2.11585","-3.8573","sp|Q13443|ADAM9_HUMAN;tr|F8WC54|F8WC54_HUMAN;tr|A0AVL1|A0AVL1_HUMAN;tr|A0A0J9YY58|A0A0J9YY58_HUMAN","sp|Q13443|ADAM9_HUMAN;tr|F8WC54|F8WC54_HUMAN;tr|A0AVL1|A0AVL1_HUMAN",2257,"Q13443","ADAM9_HUMAN","Disintegrin and metalloproteinase domain-containing protein 9","DAM 9","ADAM9"]
["16.0021","17.3186","17.2918","20.2778",{"$nulls":3},"rRNA 2'-O-methylation","RNA binding;rRNA (guanosine-2'-O-)-methyltransferase activity","mitochondrial matrix;mitochondrion",{"$nulls":3},4,4,4,"11.4","11.4","11.4","47.019",0,"8.7622",43874000,4,"0.491225",1,"-2.12444","-1.302","sp|Q9HC36|MRM3_HUMAN;tr|I3L0T6|I3L0T6_HUMAN;tr|I3L443|I3L443_HUMAN","sp|Q9HC36|MRM3_HUMAN",4318,"Q9HC36","MRM3_HUMAN","rRNA methyltransferase 3, mitochondrial {ECO:0000303|PubMed:25009282}",null,"MRM3"]
["16.8189","20.3514","20.811","20.6209",{"$nulls":3},"autophagy;cell-cell signaling;epithelial cell differentiation;inflammatory response;innate immune response;intracellular signal transduction;leukocyte activation;neutrophil degranulation;phosphorylation;positive regulation of protein sumoylation;protein localization to endosome;signal transduction;ubiquitin-dependent protein catabolic process","interleukin-1, Type I receptor binding;kinase binding;signal transducer activity;SUMO binding;Toll-like receptor binding;ubiquitin binding;ubiquitin conjugating enzyme binding;ubiquitin protein ligase binding","azurophil granule lumen;cytoplasm;cytosol;extracellular exosome;extracellular region;interleukin-1 receptor complex;interleukin-18 receptor complex;nuclear body;perinuclear region of cytoplasm;specific granule lumen","Toll-like receptor signaling pathway",null,null,4,4,4,"16.1","16.1","16.1","30.281","0.0002661","7.677",166230000,5,"0.454009",1,"-2.13078","-1.20464","sp|Q9H0E2|TOLIP_HUMAN;tr|F2Z2Y8|F2Z2Y8_HUMAN;tr|E9PNS3|E9PNS3_HUMAN;tr|E9PP67|E9PP67_HUMAN;tr|E9PQ25|E9PQ25_HUMAN;tr|E7EN89|E7EN89_HUMAN","sp|Q9H0E2|TOLIP_HUMAN;tr|F2Z2Y8|F2Z2Y8_HUMAN;tr|E9PNS3|E9PNS3_HUMAN;tr|E9PP67|E9PP67_HUMAN;tr|E9PQ25|E9PQ25_HUMAN;tr|E7EN89|E7EN89_HUMAN",4133,"Q9H0E2","TOLIP_HUMAN","Toll-interacting protein",null,"TOLLIP"]
["14.7663","18.9892","19.0203","19.2096",{"$nulls":9},2,2,2,"6.8","6.8","6.8","34.815","0.00024266","5.7218",37736000,7,"0.397082",1,"-2.23717","-1.05848","tr|Q9UFM8|Q9UFM8_HUMAN;sp|Q9Y639|NPTN_HUMAN;tr|H3BQ94|H3BQ94_HUMAN;tr|H3BU51|H3BU51_HUMAN","tr|Q9UFM8|Q9UFM8_HUMAN;sp|Q9Y639|NPTN_HUMAN;tr|H3BQ94|H3BQ94_HUMAN;tr|H3BU51|H3BU51_HUMAN",5076,"Q9UFM8","Q9UFM8_HUMAN",null,null,"DKFZp566H1924"]
["15.8996","15.8309","17.545","18.703",{"$nulls":3},"angiogenesis involved in wound healing;cell-matrix adhesion;glycosaminoglycan catabolic process;heparan sulfate proteoglycan catabolic process;neutrophil degranulation;positive regulation of blood coagulation;positive regulation of hair follicle development;positive regulation of osteoblast proliferation;positive regulation of protein kinase B signaling;positive regulation of vascular endothelial growth factor production;proteoglycan metabolic process;regulation of hair follicle development;vascular wound healing","beta-glucuronidase activity;heparanase activity;protein dimerization activity;syndecan binding","extracellular region;intracellular membrane-bounded organelle;lysosomal lumen;lysosomal membrane;lysosome;membrane raft;nucleoplasm;nucleus;proteinaceous extracellular matrix;specific granule lumen","Glycosaminoglycan degradation;Metabolic pathways;Proteoglycans in cancer",null,null,10,10,10,"20.1","20.1","20.1","61.148",0,"28.268",476520000,44,"1.22144",1,"-2.25877","-3.8944","sp|Q9Y251|HPSE_HUMAN","sp|Q9Y251|HPSE_HUMAN",4894,"Q9Y251","HPSE_HUMAN","Heparanase",null,"HPSE"]
["15.7111","17.3632","20.1104","17.6663",{"$nulls":9},10,8,8,"16.1","14.5","14.5","69.948",0,"16.427",133640000,14,"0.598655",1,"-2.35122","-1.594","tr|J9JID7|J9JID7_HUMAN;sp|Q03252|LMNB2_HUMAN","tr|J9JID7|J9JID7_HUMAN;sp|Q03252|LMNB2_HUMAN",2082,"J9JID7"]
["17.4884","17.2192","19.9499","19.5609",{"$nulls":3},"apoptotic chromosome condensation;cellular response to DNA damage stimulus;chromosome segregation;DNA ligation;DNA topological change;embryonic cleavage;hematopoietic progenitor cell differentiation;mitotic DNA integrity checkpoint;negative regulation of DNA duplex unwinding;positive regulation of apoptotic process;positive regulation of single stranded viral RNA replication via double stranded DNA intermediate;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral genome replication;protein sumoylation;regulation of circadian rhythm;resolution of meiotic recombination intermediates;rhythmic process;sister chromatid segregation","ATP binding;chromatin binding;DNA binding;DNA binding, bending;DNA topoisomerase type II (ATP-hydrolyzing) activity;DNA-dependent ATPase activity;drug binding;enzyme binding;histone deacetylase binding;magnesium ion binding;protein C-terminus binding;protein heterodimerization activity;protein homodimerization activity;protein kinase C binding;RNA binding;ubiquitin binding","condensed chromosome;cytoplasm;DNA topoisomerase complex (ATP-hydrolyzing);intracellular ribonucleoprotein complex;nucleolus;nucleoplasm;nucleus;protein complex","Platinum drug resistance",null,null,50,36,36,38,"29.7","29.7","174.38",0,"251.71",2058700000,195,"2.01941",1,"-2.40159","-10.1525","sp|P11388|TOP2A_HUMAN;tr|J3KTB7|J3KTB7_HUMAN","sp|P11388|TOP2A_HUMAN",996,"P11388","TOP2A_HUMAN","DNA topoisomerase 2-alpha",null,"TOP2A"]
["13.7407","16.8246","17.0959","18.4572",{"$nulls":3},"cellular zinc ion homeostasis;nucleotide-excision repair;positive regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;zinc II ion transport","cation transmembrane transporter activity;chromatin binding;DNA binding transcription factor activity;ligand-dependent nuclear receptor binding;ligand-dependent nuclear receptor transcription coactivator activity","cytoplasmic vesicle;cytoskeleton;endoplasmic reticulum;integral component of membrane;nucleus",{"$nulls":3},7,7,7,"12.9","12.9","12.9","63.514",0,"12.611",148040000,22,"0.55736",1,"-2.49384","-1.47959","sp|Q6PML9|ZNT9_HUMAN;tr|D6R9M6|D6R9M6_HUMAN","sp|Q6PML9|ZNT9_HUMAN",2890,"Q6PML9","ZNT9_HUMAN","Zinc transporter 9","nT-9","SLC30A9"]
["15.8133","12.8636","20.1313","13.6663",{"$nulls":3},"nucleotide-excision repair;transcription, DNA-templated",null,"core TFIIH complex",{"$nulls":3},7,7,7,32,32,32,"28.483",0,"19.087",307050000,31,"0.262815",1,"-2.56038","-0.720616","tr|D6RID8|D6RID8_HUMAN;sp|Q6P1K8|T2H2L_HUMAN;sp|Q13888|TF2H2_HUMAN;tr|D6RJD3|D6RJD3_HUMAN;tr|D6RIT7|D6RIT7_HUMAN;tr|D6RGC9|D6RGC9_HUMAN;tr|R4GMS9|R4GMS9_HUMAN;tr|D6RAW1|D6RAW1_HUMAN;tr|R4GMV2|R4GMV2_HUMAN","tr|D6RID8|D6RID8_HUMAN;sp|Q6P1K8|T2H2L_HUMAN;sp|Q13888|TF2H2_HUMAN;tr|D6RJD3|D6RJD3_HUMAN",2314,"D6RID8","D6RID8_HUMAN",null,null,"GTF2H2C"]
["13.4307","13.8895","16.3982","16.1615",{"$nulls":4},"calcium ion binding",{"$nulls":4},5,5,5,5,5,5,"130.01","0.00025793","7.033",29857000,4,"2.01912",1,"-2.61972","-10.1491","tr|F8W7U0|F8W7U0_HUMAN;sp|Q15811|ITSN1_HUMAN;tr|A8CTZ0|A8CTZ0_HUMAN;CON__ENSEMBL:ENSBTAP00000001528;tr|H7C429|H7C429_HUMAN;tr|C9JXS9|C9JXS9_HUMAN;tr|C9J1A4|C9J1A4_HUMAN;tr|H0Y523|H0Y523_HUMAN;tr|C9JQZ7|C9JQZ7_HUMAN","tr|F8W7U0|F8W7U0_HUMAN;sp|Q15811|ITSN1_HUMAN;tr|A8CTZ0|A8CTZ0_HUMAN",2524,"F8W7U0","F8W7U0_HUMAN",null,null,"ITSN1"]
["15.9799",1,"21.2455",1,{"$nulls":3},"cell aging;maintenance of protein location in nucleus;negative regulation of fibroblast proliferation;peptidyl-serine phosphorylation;post-embryonic development;protein phosphorylation;protein stabilization;viral process","RNA binding;zinc ion binding","nuclear matrix;nucleoplasm;PML body",{"$nulls":3},2,2,2,"2.2","2.2","2.2","107.11","0.00068524","4.4857",145070000,3,"0.0686692",1,"-2.63278","-0.209077","sp|Q14149|MORC3_HUMAN","sp|Q14149|MORC3_HUMAN",2335,"Q14149","MORC3_HUMAN","MORC family CW-type zinc finger protein 3",null,"MORC3"]
["17.4965","18.7438","22.1517","19.54",{"$nulls":3},"antigen receptor-mediated signaling pathway","CD4 receptor binding","cytosol;endosome membrane;intracellular membrane-bounded organelle;trans-Golgi network transport vesicle","Endocytosis",null,null,3,3,3,13,13,13,"34.96",0,"8.2643",114550000,5,"0.698277",1,"-2.72568","-1.88353","sp|Q9NZD8|SPG21_HUMAN;tr|H0YML6|H0YML6_HUMAN;tr|H0YLD7|H0YLD7_HUMAN;tr|H0YLW1|H0YLW1_HUMAN;tr|H0YLT5|H0YLT5_HUMAN;tr|H0YKM6|H0YKM6_HUMAN;tr|H0YMB7|H0YMB7_HUMAN;tr|H0YKB0|H0YKB0_HUMAN;tr|H3BRR0|H3BRR0_HUMAN","sp|Q9NZD8|SPG21_HUMAN;tr|H0YML6|H0YML6_HUMAN;tr|H0YLD7|H0YLD7_HUMAN;tr|H0YLW1|H0YLW1_HUMAN;tr|H0YLT5|H0YLT5_HUMAN;tr|H0YKM6|H0YKM6_HUMAN;tr|H0YMB7|H0YMB7_HUMAN;tr|H0YKB0|H0YKB0_HUMAN",4588,"Q9NZD8","SPG21_HUMAN","Maspardin",null,"SPG21"]
["19.1702","15.053","20.3264","19.6309",{"$nulls":3},"fibroblast growth factor receptor signaling pathway;platelet aggregation","fibroblast growth factor binding","endomembrane system;extracellular exosome;membrane;mitochondrion;nuclear speck;nucleus",{"$nulls":3},16,16,16,"51.6","51.6","51.6","41.878",0,"113.34",743750000,71,"0.518039",1,"-2.86704","-1.37324","sp|O43427|FIBP_HUMAN;tr|E9PSD3|E9PSD3_HUMAN;tr|H0YCE7|H0YCE7_HUMAN;tr|E9PJW6|E9PJW6_HUMAN","sp|O43427|FIBP_HUMAN;tr|E9PSD3|E9PSD3_HUMAN;tr|H0YCE7|H0YCE7_HUMAN",399,"O43427","FIBP_HUMAN","Acidic fibroblast growth factor intracellular-binding protein","FGF intracellular-binding protein","FIBP"]
["22.2301","16.5775","22.2951","22.4301",{"$nulls":5},"cytosol;nucleus",{"$nulls":3},4,4,4,"41.4","41.4","41.4","14.665",0,"138.14",241400000,10,"0.392403",1,"-2.95879","-1.04659","tr|C9J8R4|C9J8R4_HUMAN;tr|C9JVE2|C9JVE2_HUMAN;sp|Q96GG9|DCNL1_HUMAN;tr|C9JRU6|C9JRU6_HUMAN;tr|C9J0B2|C9J0B2_HUMAN;tr|C9JUW4|C9JUW4_HUMAN","tr|C9J8R4|C9J8R4_HUMAN;tr|C9JVE2|C9JVE2_HUMAN;sp|Q96GG9|DCNL1_HUMAN;tr|C9JRU6|C9JRU6_HUMAN;tr|C9J0B2|C9J0B2_HUMAN;tr|C9JUW4|C9JUW4_HUMAN",3703,"C9J8R4","C9J8R4_HUMAN","DCN1-like protein {ECO:0000256|RuleBase:RU363131}",null,"DCUN1D1"]
[1,"17.6049",1,"24.7587",{"$nulls":3},"rRNA processing;tRNA 5'-leader removal","ribonuclease P activity","fibrillar center;nucleolar ribonuclease P complex;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes;RNA transport",null,null,3,3,3,"9.9","9.9","9.9","31.834","0.00067583","4.2459",515610000,4,"0.0819252",1,"-3.57689","-0.246799","sp|P78345|RPP38_HUMAN;tr|Q5VUC9|Q5VUC9_HUMAN;tr|Q5VUC3|Q5VUC3_HUMAN","sp|P78345|RPP38_HUMAN",1972,"P78345","RPP38_HUMAN","Ribonuclease P protein subunit p38","NaseP protein p38","RPP38"]
["14.5136","12.0315","17.5258","16.3848",{"$nulls":3},"chromatin remodeling;DNA-templated transcription, initiation;histone H3 acetylation;regulation of DNA binding transcription factor activity;regulation of transcription from RNA polymerase II promoter","DNA binding;protein heterodimerization activity;transcription coactivator activity","extracellular exosome;histone deacetylase complex;nucleoplasm;nucleus;STAGA complex","Basal transcription factors",null,null,14,14,14,"34.1","34.1","34.1","67.814",0,"59.368",445700000,54,"0.941464",1,"-3.68274","-2.69618","sp|Q9Y6J9|TAF6L_HUMAN;tr|E9PP94|E9PP94_HUMAN","sp|Q9Y6J9|TAF6L_HUMAN",5101,"Q9Y6J9","TAF6L_HUMAN","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L",null,"TAF6L"]
[1,"13.9294","12.1853","12.4413",{"$nulls":3},"chromatin silencing by small RNA;RNA interference",null,"catalytic step 2 spliceosome",{"$nulls":3},9,9,9,"10.7","10.7","10.7","132.67",0,"32.046",239060000,36,"0.274457",1,"-4.84856","-0.749856","sp|Q9H7Z3|NRDE2_HUMAN;tr|H0YJT6|H0YJT6_HUMAN","sp|Q9H7Z3|NRDE2_HUMAN",4247,"Q9H7Z3","NRDE2_HUMAN","Protein NRDE2 homolog",null,"NRDE2"]
[1,"15.5568","13.0618","14.4433",{"$nulls":3},"protein deubiquitination;translesion synthesis;ubiquitin-dependent protein catabolic process","ISG15-specific protease activity;thiol-dependent ubiquitin-specific protease activity","nucleoplasm;nucleus",{"$nulls":3},9,9,9,11,11,11,"122.81",0,"23.669",136880000,30,"0.274013",1,"-5.47414","-0.748743","sp|Q70EL4|UBP43_HUMAN;tr|V9GXZ5|V9GXZ5_HUMAN;tr|V9GZ20|V9GZ20_HUMAN","sp|Q70EL4|UBP43_HUMAN;tr|V9GXZ5|V9GXZ5_HUMAN",2944,"Q70EL4","UBP43_HUMAN","Ubiquitin carboxyl-terminal hydrolase 43",null,"USP43"]
["16.8441",1,"14.157","14.7771",{"$nulls":3},"nuclear-transcribed mRNA poly(A) tail shortening;RNA 3'-end processing","RNA binding;RNA uridylyltransferase activity;zinc ion binding","cytosol;nucleoplasm",{"$nulls":3},5,5,5,"4.3","4.3","4.3","171.23",0,"9.4748",35565000,8,"0.254382",1,"-5.54497","-0.699404","sp|Q5VYS8|TUT7_HUMAN;tr|X6R3Q3|X6R3Q3_HUMAN","sp|Q5VYS8|TUT7_HUMAN",2768,"Q5VYS8","TUT7_HUMAN","Terminal uridylyltransferase 7","UTase 7","ZCCHC6"]
["18.2326",1,"15.8701","14.8945",{"$nulls":3},"hematopoietic progenitor cell differentiation",null,"mitochondrion",{"$nulls":3},3,3,3,"9.6","9.6","9.6","48.886","0.0096154","2.2326",21963000,3,"0.241971",1,"-5.76602","-0.668128","tr|X5D289|X5D289_HUMAN;sp|Q9NPH0|PPA6_HUMAN;tr|A0A087WW36|A0A087WW36_HUMAN;tr|A0A087WYU6|A0A087WYU6_HUMAN;tr|A0A0A0MS36|A0A0A0MS36_HUMAN;tr|V9GZ71|V9GZ71_HUMAN","tr|X5D289|X5D289_HUMAN;sp|Q9NPH0|PPA6_HUMAN;tr|A0A087WW36|A0A087WW36_HUMAN;tr|A0A087WYU6|A0A087WYU6_HUMAN;tr|A0A0A0MS36|A0A0A0MS36_HUMAN",4369,"X5D289","X5D289_HUMAN"]
[1,"17.959","13.8998","16.8104",{"$nulls":3},"head development;negative regulation of Wnt signaling pathway;positive regulation of protein oligomerization;positive regulation of protein oxidation;proteolysis;Wnt signaling pathway","endopeptidase activity;metal ion binding;metalloendopeptidase activity;Wnt-protein binding","integral component of organelle membrane;integral component of plasma membrane",{"$nulls":3},9,9,9,"28.9","28.9","28.9","57.676",0,"17.727",134810000,24,"0.247844",1,"-5.87564","-0.68294","sp|Q86V40|TIKI1_HUMAN;tr|C9IYB5|C9IYB5_HUMAN;sp|A6NFA1|TIKI2_HUMAN","sp|Q86V40|TIKI1_HUMAN;tr|C9IYB5|C9IYB5_HUMAN",3056,"Q86V40","TIKI1_HUMAN","Metalloprotease TIKI1",null,"TRABD2A"]
["16.9166",1,"17.1001","12.7288",{"$nulls":3},"cell migration;glycosaminoglycan biosynthetic process;glycosaminoglycan catabolic process;glycosaminoglycan metabolic process;inner ear receptor stereocilium organization;leukocyte migration;negative regulation of T cell proliferation;neural tube closure;positive regulation of exosomal secretion;positive regulation of extracellular exosome assembly;positive regulation of focal adhesion assembly;positive regulation of protein kinase activity;positive regulation of stress fiber assembly;regulation of fibroblast migration;retinoid metabolic process;ureteric bud development;wound healing","fibronectin binding;identical protein binding;protein kinase C binding;thrombospondin receptor activity","cell surface;costamere;extracellular exosome;focal adhesion;Golgi lumen;integral component of plasma membrane;lysosomal lumen;membrane raft;plasma membrane","Cell adhesion molecules (CAMs);ECM-receptor interaction;Fluid shear stress and atherosclerosis;Proteoglycans in cancer",null,null,1,1,1,"6.1","6.1","6.1","21.641","0.0023143","3.3305",5786200,4,"0.263246",1,"-5.95616","-0.721698","sp|P31431|SDC4_HUMAN","sp|P31431|SDC4_HUMAN",1331,"P31431","SDC4_HUMAN","Syndecan-4","YND4","SDC4"]
["14.8079",1,"14.1535","13.6484",{"$nulls":4},"RNA binding",{"$nulls":4},3,3,3,3,3,3,"171.15","0.0066995","2.5199",19554000,3,"0.321592",1,"-5.99699","-0.868053","tr|H7C5R8|H7C5R8_HUMAN;sp|Q460N5|PAR14_HUMAN","tr|H7C5R8|H7C5R8_HUMAN;sp|Q460N5|PAR14_HUMAN",2624,"H7C5R8","H7C5R8_HUMAN",null,null,"PARP14"]
["15.6188",1,"15.9339","12.6999",{"$nulls":3},"androgen receptor signaling pathway;axis elongation involved in somitogenesis;canonical Wnt signaling pathway;embryonic brain development;embryonic neurocranium morphogenesis;endoderm development;heart development;intracellular steroid hormone receptor signaling pathway;negative regulation of Wnt signaling pathway;neural tube closure;oligodendrocyte development;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;post-anal tail morphogenesis;Schwann cell development;spinal cord development;stem cell population maintenance;transcription initiation from RNA polymerase II promoter;Wnt signaling pathway, planar cell polarity pathway","beta-catenin binding;chromatin binding;ligand-dependent nuclear receptor transcription coactivator activity;protein C-terminus binding;protein domain specific binding;receptor activity;RNA polymerase II distal enhancer sequence-specific DNA binding;RNA polymerase II transcription coactivator activity;RNA polymerase II transcription cofactor activity;thyroid hormone receptor binding;transcription coactivator activity;transcription cofactor activity;ubiquitin protein ligase activity;vitamin D receptor binding","mediator complex;membrane;nucleoplasm;nucleus;ubiquitin ligase complex","Thyroid hormone signaling pathway",null,null,12,12,12,"8.3","8.3","8.3","243.08",0,"47.13",287060000,28,"0.295438",1,"-6.00748","-0.802479","sp|Q93074|MED12_HUMAN;tr|Q7Z3Z5|Q7Z3Z5_HUMAN;tr|H7C191|H7C191_HUMAN;tr|F8WAE6|F8WAE6_HUMAN;sp|Q86YW9|MD12L_HUMAN","sp|Q93074|MED12_HUMAN;tr|Q7Z3Z5|Q7Z3Z5_HUMAN",3571,"Q93074","MED12_HUMAN","Mediator of RNA polymerase II transcription subunit 12",null,"MED12"]
["19.784",1,"20.0107","12.976",{"$nulls":3},"RNA secondary structure unwinding;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;membrane;nucleolus;nucleoplasm",{"$nulls":3},10,10,10,"24.7","24.7","24.7","67.497",0,"128.29",611530000,27,"0.218366",1,"-6.10137","-0.60837","sp|Q9Y2R4|DDX52_HUMAN;tr|A0A087X121|A0A087X121_HUMAN","sp|Q9Y2R4|DDX52_HUMAN",4929,"Q9Y2R4","DDX52_HUMAN","Probable ATP-dependent RNA helicase DDX52",null,"DDX52"]
["19.5365",1,"16.9612","15.981",{"$nulls":3},"oxidative phosphorylation;regulation of transcription, DNA-templated;transcription from mitochondrial promoter","DNA polymerase processivity factor activity;RNA binding","intracellular ribonucleoprotein complex;mitochondrial matrix;mitochondrial nucleoid;mitochondrion",{"$nulls":3},9,9,9,"34.2","34.2","34.2","41.676",0,"59.042",499180000,33,"0.242049",1,"-6.20286","-0.668326","sp|Q96QE5|TEFM_HUMAN;tr|J3KTG7|J3KTG7_HUMAN","sp|Q96QE5|TEFM_HUMAN",3795,"Q96QE5","TEFM_HUMAN","Transcription elongation factor, mitochondrial",null,"TEFM"]
[1,"14.1473","13.5868","14.0602",{"$nulls":3},"apoptotic DNA fragmentation;conversion of ds siRNA to ss siRNA;conversion of ds siRNA to ss siRNA involved in RNA interference;miRNA loading onto RISC involved in gene silencing by miRNA;miRNA metabolic process;negative regulation of Schwann cell proliferation;negative regulation of transcription from RNA polymerase II promoter;nerve development;neuron projection morphogenesis;peripheral nervous system myelin formation;positive regulation of myelination;positive regulation of Schwann cell differentiation;pre-miRNA processing;production of miRNAs involved in gene silencing by miRNA;production of siRNA involved in RNA interference;RNA phosphodiester bond hydrolysis, endonucleolytic;siRNA loading onto RISC involved in RNA interference;targeting of mRNA for destruction involved in RNA interference","ATP binding;deoxyribonuclease I activity;DNA binding;double-stranded RNA binding;endoribonuclease activity;helicase activity;metal ion binding;pre-miRNA binding;protein domain specific binding;ribonuclease III activity;siRNA binding","ARC complex;axon;cytoplasm;cytosol;dendrite;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;growth cone;micro-ribonucleoprotein complex;nucleus;RISC-loading complex","MicroRNAs in cancer",null,null,2,2,2,"1.4","1.4","1.4","218.68","0.00088086","3.9612",12899000,1,"0.354256",1,"-6.24987","-0.950132","sp|Q9UPY3|DICER_HUMAN","sp|Q9UPY3|DICER_HUMAN",4875,"Q9UPY3","DICER_HUMAN","Endoribonuclease Dicer",null,"DICER1"]
[1,"13.0469","13.3904","13.252",{"$nulls":3},"negative regulation of G0 to G1 transition;transcription, DNA-templated","DNA binding;DNA binding transcription factor activity;protein dimerization activity","MLL1 complex;nucleoplasm",{"$nulls":3},11,11,11,6,6,6,"331.83",0,"27.955",127000000,35,"0.391967",1,"-6.29778","-1.04548","sp|Q8IWI9|MGAP_HUMAN;tr|H3BU53|H3BU53_HUMAN;tr|H3BP52|H3BP52_HUMAN;tr|H3BTF4|H3BTF4_HUMAN;tr|H3BTN2|H3BTN2_HUMAN","sp|Q8IWI9|MGAP_HUMAN",3129,"Q8IWI9","MGAP_HUMAN","MAX gene-associated protein",null,"MGA"]
["14.9614",1,"13.4906","15.1166",{"$nulls":3},"DNA repair;microtubule-based movement","ATP binding;DNA binding;microtubule binding;microtubule motor activity","cytosol;microtubule;nuclear speck",{"$nulls":3},13,13,13,"29.5","29.5","29.5","67.752",0,"35.896",238730000,38,"0.334197",1,"-6.32291","-0.899689","tr|H3BRB3|H3BRB3_HUMAN;sp|Q14807|KIF22_HUMAN;tr|H3BTH5|H3BTH5_HUMAN;tr|I3L306|I3L306_HUMAN","tr|H3BRB3|H3BRB3_HUMAN;sp|Q14807|KIF22_HUMAN",2399,"H3BRB3","H3BRB3_HUMAN","Kinesin-like protein {ECO:0000256|RuleBase:RU000394}",null,"KIF22"]
[1,"17.4522","16.652","14.4842",{"$nulls":3},"dephosphorylation of RNA polymerase II C-terminal domain;snRNA transcription;snRNA transcription from RNA polymerase II promoter","CTD phosphatase activity;metal ion binding;protein serine/threonine phosphatase activity","cytoplasm;cytosol;DNA-directed RNA polymerase II, holoenzyme;nucleolus;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"9.8","9.8","9.8","69.508",0,"15.722",118000000,19,"0.280235",1,"-6.34201","-0.764356","sp|Q8IXW5|RPAP2_HUMAN","sp|Q8IXW5|RPAP2_HUMAN",3152,"Q8IXW5","RPAP2_HUMAN","Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2",null,"RPAP2"]
[1,"16.5475","14.7758","15.505",{"$nulls":3},"aging;base-excision repair, gap-filling;cellular response to glucose stimulus;DNA metabolic process;DNA-dependent DNA replication;mitochondrial DNA replication;response to gamma radiation;response to hyperoxia;response to light stimulus","3'-5' exonuclease activity;chromatin binding;DNA binding;DNA-directed DNA polymerase activity;protease binding","extracellular exosome;gamma DNA polymerase complex;mitochondrial nucleoid;mitochondrion;protein complex;terminal bouton",{"$nulls":3},5,5,5,"5.5","5.5","5.5","139.56","0.00026008","7.2074",32733000,6,"0.301668",1,"-6.36665","-0.818096","sp|P54098|DPOG1_HUMAN;tr|H0YD36|H0YD36_HUMAN;tr|H0YE43|H0YE43_HUMAN;tr|H0YCV2|H0YCV2_HUMAN;tr|A0A0D9SFM1|A0A0D9SFM1_HUMAN","sp|P54098|DPOG1_HUMAN",1730,"P54098","DPOG1_HUMAN","DNA polymerase subunit gamma-1",null,"POLG"]
[1,"14.8064","13.4571","15.1891",{"$nulls":3},"intermediate filament organization;negative regulation of cell migration;negative regulation of epithelial cell proliferation;negative regulation of keratinocyte migration;negative regulation of keratinocyte proliferation;negative regulation of wound healing;regulation of epithelium regeneration;wound healing","cytoskeletal protein binding;intermediate filament binding;RNA binding","apicolateral plasma membrane;basolateral plasma membrane;bicellular tight junction;cell periphery;cell projection;cytoplasm;cytoskeleton;hemidesmosome;keratin filament;perinucleolar compartment",{"$nulls":3},100,3,3,"59.4","2.1","2.1","555.61",0,"14.383",31896000,6,"0.343378",1,"-6.41993","-0.922761","sp|P58107|EPIPL_HUMAN","sp|P58107|EPIPL_HUMAN",1799,"P58107","EPIPL_HUMAN","Epiplakin {ECO:0000303|PubMed:11278896}",null,"EPPK1"]
[1,"19.5336","15.208","18.1781",{"$nulls":3},"glucose homeostasis;intracellular protein transport;positive regulation of protein modification process;regulation of glucose import",null,"cytoplasmic side of plasma membrane;cytosol;endomembrane system;endoplasmic reticulum-Golgi intermediate compartment membrane;extrinsic component of membrane;intracellular membrane-bounded organelle;nucleoplasm;perinuclear region of cytoplasm;plasma membrane;vesicle membrane","Transcriptional misregulation in cancer",null,null,4,4,4,11,11,11,"60.182",0,"8.0051",35979000,5,"0.248558",1,"-6.42628","-0.684739","sp|Q9BZE9|ASPC1_HUMAN;tr|J3KRY8|J3KRY8_HUMAN;tr|J3QR12|J3QR12_HUMAN;tr|C9JAL9|C9JAL9_HUMAN;tr|J3QR50|J3QR50_HUMAN;tr|J3KRF7|J3KRF7_HUMAN;tr|J3QRW3|J3QRW3_HUMAN;tr|J3QL04|J3QL04_HUMAN","sp|Q9BZE9|ASPC1_HUMAN;tr|J3KRY8|J3KRY8_HUMAN;tr|J3QR12|J3QR12_HUMAN",4075,"Q9BZE9","ASPC1_HUMAN","Tether containing UBX domain for GLUT4",null,"ASPSCR1"]
[1,"16.3342","15.5732","14.8698",{"$nulls":5},"integral component of membrane",{"$nulls":3},10,10,10,"29.3","29.3","29.3","59.372",0,"24.935",162720000,29,"0.315982",1,"-6.55443","-0.853982","tr|E9PC87|E9PC87_HUMAN;sp|O94876|TMCC1_HUMAN;tr|Q6N039|Q6N039_HUMAN","tr|E9PC87|E9PC87_HUMAN;sp|O94876|TMCC1_HUMAN;tr|Q6N039|Q6N039_HUMAN",663,"E9PC87","E9PC87_HUMAN",null,null,"TMCC1"]
[1,"16.2423","16.261","14.1352",{"$nulls":3},"actin cytoskeleton organization;activation of protein kinase activity;apoptotic process;cell migration;cytoskeleton organization;regulation of apoptotic process;regulation of MAPK cascade;regulation of mitotic cell cycle;regulation of transcription, DNA-templated;Rho protein signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;cadherin binding;protein serine/threonine kinase activity;Rac GTPase binding","cell junction;cytoplasm;fibrillar center;nucleus","Axon guidance;ErbB signaling pathway;Focal adhesion;Human immunodeficiency virus 1 infection;Ras signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma;T cell receptor signaling pathway",null,null,8,8,8,"18.4","18.4","18.4","74.868",0,"18.979",160910000,22,"0.316274",1,"-6.57695","-0.854713","sp|Q9NQU5|PAK6_HUMAN;tr|H0YL16|H0YL16_HUMAN;tr|H0YM99|H0YM99_HUMAN;tr|H0YK74|H0YK74_HUMAN;tr|H0YK91|H0YK91_HUMAN;tr|H0YLZ9|H0YLZ9_HUMAN;tr|H0YMS4|H0YMS4_HUMAN","sp|Q9NQU5|PAK6_HUMAN",4396,"Q9NQU5","PAK6_HUMAN","Serine/threonine-protein kinase PAK 6",null,"PAK6"]
[1,"13.6725","14.5486","13.3055",{"$nulls":5},"cytosol;microtubule organizing center",{"$nulls":3},2,2,2,"2.5","2.5","2.5","90.309","0.00023568","5.1407",210190000,5,"0.387919",1,"-6.5908","-1.0352","tr|E9PG22|E9PG22_HUMAN;sp|Q8IW35|CEP97_HUMAN","tr|E9PG22|E9PG22_HUMAN;sp|Q8IW35|CEP97_HUMAN",3120,"E9PG22","E9PG22_HUMAN",null,null,"CEP97"]
["15.6914",1,"16.1924","13.694",{"$nulls":5},"intracellular membrane-bounded organelle",{"$nulls":3},2,2,2,"2.2","2.2","2.2","105.55","0.0094303","2.2422",29884000,5,"0.328517",1,"-6.59749","-0.885429","tr|B1AKL4|B1AKL4_HUMAN;sp|Q9NRA8|4ET_HUMAN;tr|B0QYZ7|B0QYZ7_HUMAN","tr|B1AKL4|B1AKL4_HUMAN;sp|Q9NRA8|4ET_HUMAN;tr|B0QYZ7|B0QYZ7_HUMAN",4413,"B1AKL4","B1AKL4_HUMAN",null,null,"EIF4ENIF1"]
["14.6526",1,"14.6719","14.2863",{"$nulls":3},"endosomal transport;endosome organization;protein transport",null,"early endosome;endosome;WASH complex","Endocytosis",null,null,2,2,2,"3.2","3.2","3.2","136.4","0.00068792","4.5645",9641400,3,"0.363799",1,"-6.65276","-0.974188","sp|Q2M389|WASH7_HUMAN;tr|A0A087X256|A0A087X256_HUMAN;tr|F8VYH7|F8VYH7_HUMAN","sp|Q2M389|WASH7_HUMAN;tr|A0A087X256|A0A087X256_HUMAN;tr|F8VYH7|F8VYH7_HUMAN",2594,"Q2M389","WASC4_HUMAN","WASH complex subunit 4 {ECO:0000312|HGNC:HGNC:29174}",null,"WASHC4"]
["14.2504",1,"14.4629","14.1405",{"$nulls":3},"rRNA modification;rRNA processing","cadherin binding;histone methyltransferase binding;RNA binding;snoRNA binding","box C/D snoRNP complex;cytoplasm;fibrillar center;membrane;nucleolus;nucleoplasm;pre-snoRNP complex;small nucleolar ribonucleoprotein complex;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,15,15,15,"35.2","35.2","35.2","66.049",0,"84.907",530850000,77,"0.376964",1,"-6.67651","-1.00745","sp|O00567|NOP56_HUMAN;tr|Q5JXT2|Q5JXT2_HUMAN;tr|H0Y653|H0Y653_HUMAN;tr|H0YDU4|H0YDU4_HUMAN","sp|O00567|NOP56_HUMAN",244,"O00567","NOP56_HUMAN","Nucleolar protein 56",null,"NOP56"]
["16.6821",1,"15.8647","15.1808",{"$nulls":3},"autophagosome maturation;endosome to lysosome transport;lysosome localization;melanosome localization;platelet formation;protein transport;regulation of developmental pigmentation;regulation of lysosomal lumen pH;vesicle docking involved in exocytosis;vesicle-mediated transport",null,"autophagosome;clathrin-coated vesicle;early endosome;HOPS complex;late endosome;late endosome membrane;lysosomal membrane;perinuclear region of cytoplasm",{"$nulls":3},4,4,4,"12.2","12.2","12.2","67.61","0.00024661","6.0998",18998000,5,"0.314926",1,"-6.68169","-0.851334","sp|Q96AX1|VP33A_HUMAN;tr|H3BMM5|H3BMM5_HUMAN;tr|F5H2X5|F5H2X5_HUMAN","sp|Q96AX1|VP33A_HUMAN;tr|H3BMM5|H3BMM5_HUMAN;tr|F5H2X5|F5H2X5_HUMAN",3605,"Q96AX1","VP33A_HUMAN","Vacuolar protein sorting-associated protein 33A","VPS33A","VPS33A"]
["15.8247",1,"16.2953","14.0295",{"$nulls":3},"cytoskeleton organization;microtubule cytoskeleton organization;neuron projection development;regulation of cell morphogenesis;regulation of microtubule polymerization","calmodulin binding;microtubule binding;microtubule minus-end binding;spectrin binding","cytoplasm;microtubule",{"$nulls":3},4,4,4,"4.6","4.6","4.6","177.97","0.0002624","7.3979",29204000,8,"0.334396",1,"-6.75001","-0.900189","sp|Q5T5Y3|CAMP1_HUMAN","sp|Q5T5Y3|CAMP1_HUMAN",2731,"Q5T5Y3","CAMP1_HUMAN","Calmodulin-regulated spectrin-associated protein 1",null,"CAMSAP1"]
[1,"15.6159","15.5345","14.6638",{"$nulls":3},"adaptive immune response;immune response;mucosal immune response;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interleukin-8 production;negative regulation of protein localization to nucleus;negative regulation of transcription from RNA polymerase II promoter;protein deubiquitination;protein deubiquitination involved in ubiquitin-dependent protein catabolic process;protein K11-linked deubiquitination;protein K48-linked deubiquitination;protein K63-linked deubiquitination","cysteine-type peptidase activity;DNA binding;K63-linked polyubiquitin modification-dependent protein binding;Lys48-specific deubiquitinase activity;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;zinc ion binding","cytoplasm;cytosol;nucleus",{"$nulls":3},2,2,2,"3.8","3.8","3.8","92.525","0.0058046","2.664",5810900,1,"0.345321",1,"-6.79122","-0.927646","sp|Q6GQQ9|OTU7B_HUMAN;tr|Q5SZ59|Q5SZ59_HUMAN","sp|Q6GQQ9|OTU7B_HUMAN;tr|Q5SZ59|Q5SZ59_HUMAN",2811,"Q6GQQ9","OTU7B_HUMAN","OTU domain-containing protein 7B",null,"OTUD7B"]
["14.9913",1,"15.152","14.4407",{"$nulls":3},"actin cytoskeleton organization;cell-cell junction organization;ectoderm development;hippocampus development;lens fiber cell differentiation;mesoderm formation;negative regulation of cell migration;negative regulation of cell proliferation;negative regulation of cell-cell adhesion;negative regulation of cell-matrix adhesion;negative regulation of DNA replication;negative regulation of JAK-STAT cascade;negative regulation of MAPK cascade;negative regulation of protein kinase activity;negative regulation of tyrosine phosphorylation of STAT protein;odontogenesis of dentin-containing tooth;positive regulation of cell differentiation;positive regulation of stress fiber assembly;regulation of apoptotic process;regulation of cell cycle;regulation of gliogenesis;regulation of hippo signaling;regulation of neural precursor cell proliferation;regulation of protein localization to nucleus;regulation of protein stability;regulation of stem cell proliferation;Schwann cell proliferation","actin binding","adherens junction;apical part of cell;cell body;cleavage furrow;cortical actin cytoskeleton;cytoplasm;cytoskeleton;cytosol;early endosome;filopodium membrane;lamellipodium;membrane;neuron projection;nucleolus;nucleus;perinuclear region of cytoplasm;plasma membrane;ruffle membrane","Hippo signaling pathway;Hippo signaling pathway - multiple species;Tight junction",null,null,5,5,5,"8.4","8.4","8.4","69.689",0,"10.77",24382000,4,"0.362488",1,"-6.80071","-0.97088","sp|P35240|MERL_HUMAN","sp|P35240|MERL_HUMAN",1376,"P35240","MERL_HUMAN","Merlin",null,"NF2"]
["14.4705",1,"14.5817","14.5031",{"$nulls":3},"G-protein coupled acetylcholine receptor signaling pathway;receptor clustering","calcium ion binding;laminin binding","plasma membrane",{"$nulls":3},2,2,2,"1.2","1.2","1.2","202.29","0.00068306","4.4148",15238000,1,"0.378235",1,"-6.80717","-1.01066","tr|A0A087X208|A0A087X208_HUMAN;sp|O00468|AGRIN_HUMAN;tr|H0Y5U1|H0Y5U1_HUMAN","tr|A0A087X208|A0A087X208_HUMAN;sp|O00468|AGRIN_HUMAN;tr|H0Y5U1|H0Y5U1_HUMAN",231,"A0A087X208","A0A087X208_HUMAN",null,null,"AGRN"]
[1,"18.9417","16.9282","16.6609",{"$nulls":5},"extracellular region;integral component of membrane;plasma membrane",{"$nulls":3},9,9,9,"10.5","10.5","10.5","92.931",0,"19.044",169150000,17,"0.278728",1,"-6.82375","-0.760575","sp|Q9H5V8|CDCP1_HUMAN","sp|Q9H5V8|CDCP1_HUMAN",4222,"Q9H5V8","CDCP1_HUMAN","CUB domain-containing protein 1",null,"CDCP1"]
["15.5631",1,"13.9505","16.3367",{"$nulls":3},"snRNA processing;snRNA transcription from RNA polymerase II promoter",null,"integrator complex;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"10.5","10.5","10.5","108.17","0.00068509","4.4855",27854000,7,"0.346251",1,"-6.86203","-0.929986","sp|Q96HW7|INT4_HUMAN","sp|Q96HW7|INT4_HUMAN",3724,"Q96HW7","INT4_HUMAN","Integrator complex subunit 4","nt4","INTS4"]
["20.3117",1,"17.7776","17.3386",{"$nulls":3},"mRNA splicing, via spliceosome","RNA binding",{"$nulls":4},16,1,1,"46.2","3.7","3.7","39.933","0.00066726","4.0982",73625000,6,"0.260439",1,"-6.90227","-0.714642","tr|M0QZM1|M0QZM1_HUMAN","tr|M0QZM1|M0QZM1_HUMAN",5290,"M0QZM1","M0QZM1_HUMAN",null,null,"HNRNPM"]
[1,"17.9305","16.0341","16.7697",{"$nulls":3},"mitochondrial tRNA thio-modification;tRNA wobble position uridine thiolation","ATP binding;sulfurtransferase activity;tRNA binding","mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,"5.2","5.2","5.2","47.744","0.002335","3.412",16339000,2,"0.301891",1,"-6.93665","-0.818655","sp|O75648|MTU1_HUMAN","sp|O75648|MTU1_HUMAN",597,"O75648","MTU1_HUMAN","Mitochondrial tRNA-specific 2-thiouridylase 1",null,"TRMU"]
[1,"15.5242","14.2919","16.1271",{"$nulls":3},"adipose tissue development;adrenal gland development;cell development;cellular response to leukemia inhibitory factor;face morphogenesis;fat cell differentiation;fat pad development;female gonad development;fibroblast migration;kidney development;liver development;male gonad development;multicellular organism growth;muscle organ morphogenesis;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;palate development;platelet-derived growth factor receptor signaling pathway;positive regulation of DNA binding transcription factor activity;post-embryonic development;skeletal system morphogenesis;transcription, DNA-templated","DNA binding;histone demethylase activity;RNA polymerase II regulatory region sequence-specific DNA binding;transcription coactivator activity;transcription regulatory region DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding","nucleoplasm;nucleus",{"$nulls":3},4,4,4,"5.9","5.9","5.9","132.37","0.00025413","6.7063",81192000,13,"0.353852",1,"-6.94738","-0.949114","sp|Q14865|ARI5B_HUMAN","sp|Q14865|ARI5B_HUMAN",2401,"Q14865","ARI5B_HUMAN","AT-rich interactive domain-containing protein 5B","RID domain-containing protein 5B","ARID5B"]
["15.2174",1,"16.2727","13.8759",{"$nulls":3},"alternative mRNA splicing, via spliceosome;hemopoiesis;multicellular organism development;negative regulation of stem cell differentiation;neutrophil degranulation;phosphorylation of RNA polymerase II C-terminal domain;positive regulation of cell proliferation;positive regulation of transcription from RNA polymerase II promoter;regulation of mitotic nuclear division;transcription elongation from RNA polymerase II promoter;viral process","ATP binding;cyclin binding;cyclin-dependent protein serine/threonine kinase activity;protein kinase activity;protein kinase binding;RNA binding;RNA polymerase II carboxy-terminal domain kinase activity;transcription factor binding;transcription regulatory region DNA binding","chromosome;cyclin K-CDK13 complex;cyclin/CDK positive transcription elongation factor complex;cytosol;extracellular region;extracellular space;ficolin-1-rich granule lumen;Golgi apparatus;nuclear cyclin-dependent protein kinase holoenzyme complex;nuclear speck;nucleoplasm",{"$nulls":3},11,8,8,"11.6","8.9","8.9","164.92",0,"25.826",157610000,27,"0.360647",1,"-6.96562","-0.966237","sp|Q14004|CDK13_HUMAN","sp|Q14004|CDK13_HUMAN",2320,"Q14004","CDK13_HUMAN","Cyclin-dependent kinase 13",null,"CDK13"]
["16.5739",1,"15.5186","16.007",{"$nulls":3},"DNA replication;DNA synthesis involved in DNA repair;DNA topological change;meiotic cell cycle;regulation of signal transduction by p53 class mediator;strand displacement","DNA binding;DNA topoisomerase type I activity;zinc ion binding","chromosome;nucleoplasm;nucleus;PML body","Fanconi anemia pathway;Homologous recombination",null,null,4,4,3,"6.1","6.1",5,"112.37","0.00046653","4.8776",39333000,2,"0.332486",1,"-6.97582","-0.895393","sp|Q13472|TOP3A_HUMAN;tr|K7ELI7|K7ELI7_HUMAN;tr|H7C4B0|H7C4B0_HUMAN","sp|Q13472|TOP3A_HUMAN",2264,"Q13472","TOP3A_HUMAN","DNA topoisomerase 3-alpha",null,"TOP3A"]
["17.7318",1,"18.8306","13.8996",{"$nulls":3},"negative regulation of lipid kinase activity;negative regulation of protein localization to plasma membrane;positive regulation of protein dephosphorylation;protein dephosphorylation;signal transduction","kinase binding;phosphoprotein phosphatase activity;protein phosphatase regulator activity","centrosome;chromosome, centromeric region;cytoplasm;cytosol;M band;nucleus;protein phosphatase type 2A complex;Z disc","Adrenergic signaling in cardiomyocytes;AMPK signaling pathway;Dopaminergic synapse;Human papillomavirus infection;mRNA surveillance pathway;Oocyte meiosis;PI3K-Akt signaling pathway;Sphingolipid signaling pathway",null,null,4,4,3,"9.1","9.1","7.4","56.193","0.00026042","7.2226",36717000,7,"0.295452",1,"-6.99922","-0.802514","sp|Q15172|2A5A_HUMAN","sp|Q15172|2A5A_HUMAN",2458,"Q15172","2A5A_HUMAN","Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform",null,"PPP2R5A"]
["13.8825",1,"13.9357","15.0013",{"$nulls":3},"protein deubiquitination;ubiquitin-dependent protein catabolic process","thiol-dependent ubiquitinyl hydrolase activity","nucleoplasm",{"$nulls":3},8,8,8,"3.5","3.5","3.5","294.36",0,"11.002",57306000,7,"0.408378",1,"-7.02722","-1.08726","sp|Q9UPU5|UBP24_HUMAN","sp|Q9UPU5|UBP24_HUMAN",4872,"Q9UPU5","UBP24_HUMAN","Ubiquitin carboxyl-terminal hydrolase 24",null,"USP24"]
["15.2788",1,"14.1608","16.2302",{"$nulls":3},"double-strand break repair via homologous recombination;positive regulation of mitotic cell cycle spindle assembly checkpoint;regulation of centrosome duplication;resolution of mitotic recombination intermediates;resolution of recombination intermediates","crossover junction endodeoxyribonuclease activity;DNA binding;endodeoxyribonuclease activity;metal ion binding","centrosome;extracellular exosome;nucleoplasm",{"$nulls":3},6,6,6,"7.9","7.9","7.9","102.88",0,"11.63",127310000,23,"0.365354",1,"-7.0561","-0.97811","sp|Q17RS7|GEN_HUMAN;tr|A0A087WXY3|A0A087WXY3_HUMAN","sp|Q17RS7|GEN_HUMAN",2584,"Q17RS7","GEN_HUMAN","Flap endonuclease GEN homolog 1",null,"GEN1"]
[1,"18.3346","16.4417","17.0093",{"$nulls":3},"DNA-templated transcription, initiation;negative regulation of cell cycle;negative regulation of cell proliferation;regulation of DNA binding transcription factor activity;regulation of signal transduction by p53 class mediator;snRNA transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter","aryl hydrocarbon receptor binding;DNA binding;DNA binding transcription factor activity;protein heterodimerization activity","cytosol;MLL1 complex;nucleoplasm;nucleus;protein complex;transcription factor TFIID complex;transcription factor TFTC complex","Basal transcription factors",null,null,17,17,17,36,36,36,"72.668",0,"74.378",418640000,57,"0.299998",1,"-7.05819","-0.813909","sp|P49848|TAF6_HUMAN;tr|J3KR72|J3KR72_HUMAN;tr|C9JFL8|C9JFL8_HUMAN;tr|C9JTY6|C9JTY6_HUMAN;tr|C9JIS2|C9JIS2_HUMAN;tr|E5RHA1|E5RHA1_HUMAN;tr|C9J088|C9J088_HUMAN;tr|E5RKA5|E5RKA5_HUMAN;tr|F8WEJ7|F8WEJ7_HUMAN;tr|C9J7C4|C9J7C4_HUMAN;tr|C9JHQ8|C9JHQ8_HUMAN","sp|P49848|TAF6_HUMAN;tr|J3KR72|J3KR72_HUMAN",1609,"P49848","TAF6_HUMAN","Transcription initiation factor TFIID subunit 6",null,"TAF6"]
["17.6798",1,"15.2362","17.5959",{"$nulls":3},"cellular calcium ion homeostasis;mRNA splicing, via spliceosome;negative regulation of cell proliferation;nervous system development;positive regulation of NFAT protein import into nucleus;release of sequestered calcium ion into cytosol","ion channel binding;RNA binding","cytoplasm;membrane;nucleoplasm;perinuclear region of cytoplasm;sarcoplasmic reticulum membrane","Spliceosome",null,null,13,13,13,"17.6","17.6","17.6","103.7",0,"69.577",446810000,41,"0.310447",1,"-7.07614","-0.840103","sp|Q8IWX8|CHERP_HUMAN;tr|J3QK89|J3QK89_HUMAN","sp|Q8IWX8|CHERP_HUMAN;tr|J3QK89|J3QK89_HUMAN",3137,"Q8IWX8","CHERP_HUMAN","Calcium homeostasis endoplasmic reticulum protein",null,"CHERP"]
["14.5434",1,"15.4985","14.2868",{"$nulls":9},2,2,2,"3.3","3.3","3.3","103.69","0.00066578","4.0658",14596000,6,"0.392722",1,"-7.12096","-1.04739","sp|Q7Z3E2|CC186_HUMAN;tr|A0A0C4DFU7|A0A0C4DFU7_HUMAN;tr|H0Y7V5|H0Y7V5_HUMAN","sp|Q7Z3E2|CC186_HUMAN;tr|A0A0C4DFU7|A0A0C4DFU7_HUMAN;tr|H0Y7V5|H0Y7V5_HUMAN",2993,"Q7Z3E2","CC186_HUMAN","Coiled-coil domain-containing protein 186",null,"CCDC186"]
["18.0767",1,"15.7748","17.6467",{"$nulls":3},"autophagosome maturation;endocytic recycling",null,"cytoplasm",{"$nulls":3},2,2,2,"0.9","0.9","0.9","292.48","0.0015038","3.576",135300000,4,"0.308422",1,"-7.17245","-0.835027","sp|Q9HCE0|EPG5_HUMAN;tr|K7ENK5|K7ENK5_HUMAN;tr|K7EM87|K7EM87_HUMAN;tr|K7EPN4|K7EPN4_HUMAN","sp|Q9HCE0|EPG5_HUMAN;tr|K7ENK5|K7ENK5_HUMAN;tr|K7EM87|K7EM87_HUMAN;tr|K7EPN4|K7EPN4_HUMAN",4325,"Q9HCE0","EPG5_HUMAN","Ectopic P granules protein 5 homolog",null,"EPG5"]
["15.8833",1,"16.7541","14.5732",{"$nulls":3},"cilium assembly;in utero embryonic development;inositol phosphate metabolic process;lipid metabolic process;membrane organization;phosphatidylinositol biosynthetic process;phosphatidylinositol dephosphorylation;regulation of GTPase activity;regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity;inositol phosphate phosphatase activity;inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;inositol-1,4,5-trisphosphate 5-phosphatase activity;phosphatidylinositol phosphate 4-phosphatase activity;phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;Rac GTPase binding","clathrin-coated pit;clathrin-coated vesicle;cytoplasm;cytosol;early endosome;early endosome membrane;extracellular exosome;Golgi stack;Golgi-associated vesicle;nucleus;phagocytic vesicle membrane;photoreceptor outer segment;plasma membrane;trans-Golgi network","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,13,13,13,"16.5","16.5","16.5","104.2",0,"33.637",452910000,52,"0.358262",1,"-7.22199","-0.960226","sp|Q01968|OCRL_HUMAN","sp|Q01968|OCRL_HUMAN",2059,"Q01968","OCRL_HUMAN","Inositol polyphosphate 5-phosphatase OCRL-1",null,"OCRL"]
[1,"20.2383","16.0593","19.669",{"$nulls":3},"brain development;covalent chromatin modification;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);rRNA processing","RNA binding","nucleolus;nucleoplasm;nucleus;small-subunit processome",{"$nulls":3},9,9,9,"27.6","27.6","27.6","54.557",0,"69.007",644200000,60,"0.270637",1,"-7.24499","-0.740266","sp|Q9NQZ2|SAS10_HUMAN","sp|Q9NQZ2|SAS10_HUMAN",4401,"Q9NQZ2","SAS10_HUMAN","Something about silencing protein 10",null,"UTP3"]
[1,"16.4792","16.4737","15.5163",{"$nulls":4},"GTP binding",{"$nulls":4},8,8,8,"22.3","22.3","22.3","56.897",0,"24.816",244710000,45,"0.348502",1,"-7.25538","-0.935648","tr|H0Y2S1|H0Y2S1_HUMAN;sp|O43824|GTPB6_HUMAN","tr|H0Y2S1|H0Y2S1_HUMAN;sp|O43824|GTPB6_HUMAN",443,"H0Y2S1","H0Y2S1_HUMAN",null,null,"GTPBP6"]
["16.5064",1,"16.0805","15.9583",{"$nulls":5},"cytosol;Golgi apparatus;Golgi membrane;plasma membrane",{"$nulls":3},3,3,3,"4.9","4.9","4.9","87.81","0.00046882","4.9784",27200000,5,"0.349102",1,"-7.26619","-0.937157","sp|Q96CN9|GCC1_HUMAN","sp|Q96CN9|GCC1_HUMAN",3638,"Q96CN9","GCC1_HUMAN","GRIP and coiled-coil domain-containing protein 1",null,"GCC1"]
[1,"18.167","17.0831","16.6413",{"$nulls":3},"actin filament bundle assembly;auditory receptor cell differentiation;brush border assembly;cellular protein complex assembly;equilibrioception;G2/M transition of mitotic cell cycle;inner ear morphogenesis;inner ear receptor stereocilium organization;parallel actin filament bundle assembly;photoreceptor cell maintenance;protein localization to microvillus;regulation of microvillus length;sensory perception of light stimulus;sensory perception of sound","actin filament binding;spectrin binding","apical part of cell;brush border;cytoplasm;cytoskeleton;cytosol;microvillus;photoreceptor inner segment;photoreceptor outer segment;plasma membrane;stereocilium;synapse",{"$nulls":3},4,4,4,"8.7","8.7","8.7","62.21",0,"9.435",38860000,4,"0.31348",1,"-7.2787","-0.847708","sp|Q9Y6N9|USH1C_HUMAN","sp|Q9Y6N9|USH1C_HUMAN",5111,"Q9Y6N9","USH1C_HUMAN","Harmonin",null,"USH1C"]
[1,"15.4367","15.3341","15.6857",{"$nulls":5},"integral component of membrane",{"$nulls":3},4,4,4,"13.6","13.6","13.6","42.403",0,"8.0823",98088000,12,"0.377908",1,"-7.29152","-1.00984","sp|Q9H1X3|DJC25_HUMAN;tr|F2Z3D1|F2Z3D1_HUMAN;tr|J3QR79|J3QR79_HUMAN;tr|A0A024R161|A0A024R161_HUMAN","sp|Q9H1X3|DJC25_HUMAN",4160,"Q9H1X3","DJC25_HUMAN","DnaJ homolog subfamily C member 25",null,"DNAJC25"]
["20.6446",1,"18.4015","17.8562",{"$nulls":3},"protein import into mitochondrial inner membrane;protein targeting to mitochondrion","mitochondrion targeting sequence binding;protein channel activity","integral component of membrane;mitochondrial inner membrane;mitochondrial inner membrane protein insertion complex",{"$nulls":3},2,2,2,"25.8","25.8","25.8","20.031","0.00025361","6.6551",33683000,4,"0.271962",1,"-7.30658","-0.743592","sp|Q9Y584|TIM22_HUMAN","sp|Q9Y584|TIM22_HUMAN",5033,"Q9Y584","TIM22_HUMAN","Mitochondrial import inner membrane translocase subunit Tim22",null,"TIMM22"]
[1,"16.0117","16.5187","15.1261",{"$nulls":3},"actin cytoskeleton organization;activation of JUN kinase activity;activation of MAPK activity;activation of MAPKK activity;activation of protein kinase activity;apoptotic process;axonogenesis;cell migration;cellular response to DNA damage stimulus;dendrite arborization;focal adhesion assembly;mitotic G2 DNA damage checkpoint;nervous system development;positive regulation of dendrite morphogenesis;positive regulation of JNK cascade;positive regulation of neuron projection development;positive regulation of protein autophosphorylation;positive regulation of stress-activated MAPK cascade;protein autophosphorylation;protein targeting to membrane;regulation of actin cytoskeleton organization;regulation of apoptotic process;regulation of cell growth;regulation of cell shape;regulation of mitotic cell cycle;response to stress;stress-activated MAPK cascade","ATP binding;MAP kinase kinase kinase activity;mitogen-activated protein kinase kinase binding;neuropilin binding;protein serine/threonine kinase activity","actin cytoskeleton;axon;axonal growth cone;cytoplasmic vesicle;cytoplasmic vesicle membrane;cytosol;dendritic growth cone;integral component of membrane;intracellular;neuron projection;nucleolus;nucleus;receptor complex","MAPK signaling pathway",null,null,16,13,13,"18.1","16.2","16.2","138.25",0,"38.766",593870000,71,"0.362383",1,"-7.31655","-0.970614","sp|Q9UL54|TAOK2_HUMAN","sp|Q9UL54|TAOK2_HUMAN",4805,"Q9UL54","TAOK2_HUMAN","Serine/threonine-protein kinase TAO2",null,"TAOK2"]
[1,"17.2665","16.7528","16.1813",{"$nulls":3},"phosphatidylglycerol acyl-chain remodeling;phospholipid biosynthetic process;positive regulation of fatty acid biosynthetic process","1-acylglycerol-3-phosphate O-acyltransferase activity;2-acylglycerol-3-phosphate O-acyltransferase activity","cytoplasm;endoplasmic reticulum membrane;integral component of membrane;membrane","Glycerophospholipid metabolism",null,null,3,3,3,"10.8","10.8","10.8","43.089","0.00025484","6.7817",45970000,6,"0.33478",1,"-7.33382","-0.901155","sp|Q92604|LGAT1_HUMAN","sp|Q92604|LGAT1_HUMAN",3504,"Q92604","LGAT1_HUMAN","Acyl-CoA:lysophosphatidylglycerol acyltransferase 1",null,"LPGAT1"]
["18.0837",1,"17.3633","16.4985",{"$nulls":3},"actin cytoskeleton organization;axon guidance;ossification;positive regulation of osteoblast differentiation;receptor-mediated endocytosis","metal ion binding","actin cytoskeleton;cell-cell adherens junction;cytosol;focal adhesion;nucleus;ruffle;stress fiber",{"$nulls":3},3,3,3,7,7,7,"49.844","0.0042962","2.926",70375000,5,"0.319952",1,"-7.38908","-0.863938","sp|Q9NR12|PDLI7_HUMAN;tr|D6RF83|D6RF83_HUMAN;tr|D6RH06|D6RH06_HUMAN;tr|H7BYK4|H7BYK4_HUMAN","sp|Q9NR12|PDLI7_HUMAN;tr|D6RF83|D6RF83_HUMAN;tr|D6RH06|D6RH06_HUMAN",4403,"Q9NR12","PDLI7_HUMAN","PDZ and LIM domain protein 7",null,"PDLIM7"]
[1,"18.9376","17.9272","16.8261",{"$nulls":9},1,1,1,"5.3","5.3","5.3","29.411","0.00023787","5.3398",30034000,7,"0.304185",1,"-7.40784","-0.824405","sp|Q6PID6|TTC33_HUMAN","sp|Q6PID6|TTC33_HUMAN",2881,"Q6PID6","TTC33_HUMAN","Tetratricopeptide repeat protein 33","PR repeat protein 33","TTC33"]
["17.1491",1,"16.448","16.5449",{"$nulls":3},"interleukin-1-mediated signaling pathway","ATP binding;protein serine/threonine kinase activity",{"$nulls":4},3,3,3,"11.2","11.2","11.2","42.111","0.00025853","7.103",30181000,8,"0.341944",1,"-7.42189","-0.919155","tr|H7C224|H7C224_HUMAN;tr|D3YTB5|D3YTB5_HUMAN;sp|P51617|IRAK1_HUMAN;tr|H7C2I6|H7C2I6_HUMAN;tr|H7C3C1|H7C3C1_HUMAN;tr|F8WAB6|F8WAB6_HUMAN","tr|H7C224|H7C224_HUMAN;tr|D3YTB5|D3YTB5_HUMAN;sp|P51617|IRAK1_HUMAN;tr|H7C2I6|H7C2I6_HUMAN",1661,"H7C224","H7C224_HUMAN",null,null,"IRAK1"]
["16.3145",1,"16.4479","15.802",{"$nulls":3},"cellular response to DNA damage stimulus;copper ion homeostasis;inhibition of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of apoptotic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of canonical Wnt signaling pathway;positive regulation of protein linear polyubiquitination;positive regulation of protein ubiquitination;regulation of BMP signaling pathway;regulation of cell proliferation;regulation of inflammatory response;regulation of innate immune response;regulation of nucleotide-binding oligomerization domain containing signaling pathway;Wnt signaling pathway","cysteine-type endopeptidase inhibitor activity involved in apoptotic process;identical protein binding;metal ion binding;ubiquitin protein ligase activity;ubiquitin-protein transferase activity","cytoplasm;cytosol;nucleoplasm;nucleus","Apoptosis;Apoptosis - multiple species;Focal adhesion;Human T-cell leukemia virus 1 infection;Necroptosis;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Pathways in cancer;Platinum drug resistance;Small cell lung cancer;Toxoplasmosis;Ubiquitin mediated proteolysis",null,null,3,3,3,"8.2","8.2","8.2","56.684","0.00046512","4.8338",36681000,5,"0.363878",1,"-7.46774","-0.974386","sp|P98170|XIAP_HUMAN;tr|B1AKU2|B1AKU2_HUMAN","sp|P98170|XIAP_HUMAN;tr|B1AKU2|B1AKU2_HUMAN",2019,"P98170","XIAP_HUMAN","E3 ubiquitin-protein ligase XIAP",null,"XIAP"]
["16.0319",1,"15.7375","16.3777",{"$nulls":3},"cellular response to fluid shear stress;chromatin organization;circadian rhythm;negative regulation of apoptotic process;negative regulation of JNK cascade;negative regulation of transcription from RNA polymerase II promoter;negative regulation of transcription, DNA-templated;positive regulation of protein phosphorylation;positive regulation of TOR signaling;positive regulation of transcription factor import into nucleus;positive regulation of transcription from RNA polymerase II promoter;protein deacetylation;regulation of lipid metabolic process;regulation of protein stability;spindle assembly;transcription, DNA-templated","chromatin binding;cyclin binding;enzyme binding;histone deacetylase activity;histone deacetylase binding;NAD-dependent histone deacetylase activity (H3-K14 specific);NF-kappaB binding;protein deacetylase activity;transcription corepressor activity;transcription factor binding","cytoplasm;cytosol;Golgi apparatus;histone deacetylase complex;nucleoplasm;nucleus;plasma membrane;spindle microtubule;transcriptional repressor complex","Alcoholism;Thyroid hormone signaling pathway;Viral carcinogenesis",null,null,3,3,3,"8.2","8.2","8.2","48.847","0.000693","4.7099",46786000,2,"0.375012",1,"-7.54165","-1.00251","sp|O15379|HDAC3_HUMAN","sp|O15379|HDAC3_HUMAN",358,"O15379","HDAC3_HUMAN","Histone deacetylase 3","D3","HDAC3"]
["15.624",1,"15.5353","16.2016",{"$nulls":5},"centrosome;cytoplasm;midbody;spindle pole",{"$nulls":3},2,2,2,"9.7","9.7","9.7","44.139","0.0036946","2.9727",18403000,3,"0.386799",1,"-7.55644","-1.03236","sp|Q9C0F1|CEP44_HUMAN;tr|D6RGX6|D6RGX6_HUMAN","sp|Q9C0F1|CEP44_HUMAN;tr|D6RGX6|D6RGX6_HUMAN",4102,"Q9C0F1","CEP44_HUMAN","Centrosomal protein of 44 kDa","ep44","CEP44"]
["16.0399",1,"15.7405","16.4341",{"$nulls":9},2,2,2,"3.6","3.6","3.6","60.659","0.0087057","2.2995",12926000,3,"0.376087",1,"-7.56733","-1.00523","tr|H7C022|H7C022_HUMAN;sp|Q8WVS4|WDR60_HUMAN","tr|H7C022|H7C022_HUMAN;sp|Q8WVS4|WDR60_HUMAN",3444,"H7C022","H7C022_HUMAN",null,null,"WDR60"]
["18.17",1,"17.5863","16.7231",{"$nulls":3},"neutrophil degranulation","nucleic acid binding;transferase activity;zinc ion binding","extracellular region;ficolin-1-rich granule lumen",{"$nulls":3},2,2,2,"4.7","4.7","4.7","41.945","0.00024759","6.1734",25324000,2,"0.326603",1,"-7.5697","-0.880626","sp|Q9P0J7|KCMF1_HUMAN","sp|Q9P0J7|KCMF1_HUMAN",4617,"Q9P0J7","KCMF1_HUMAN","E3 ubiquitin-protein ligase KCMF1",null,"KCMF1"]
[1,"16.1751","16.4155","15.9498",{"$nulls":3},"muscle contraction;muscle filament sliding;skeletal muscle tissue development","calcium ion binding;motor activity;structural constituent of muscle","cytosol;extracellular exosome;muscle myosin complex;myosin complex;unconventional myosin complex","Oxytocin signaling pathway;Tight junction;Vascular smooth muscle contraction",null,null,4,2,2,"23.1","11.5","11.5","22.764","0.00088048","3.9557",16332000,4,"0.374224",1,"-7.59507","-1.00052","sp|P14649|MYL6B_HUMAN;tr|F8W1I5|F8W1I5_HUMAN","sp|P14649|MYL6B_HUMAN;tr|F8W1I5|F8W1I5_HUMAN",1048,"P14649","MYL6B_HUMAN","Myosin light chain 6B",null,"MYL6B"]
["15.9068",1,"16.4446","15.6529",{"$nulls":3},"actin filament capping;actin filament severing;actin nucleation;calcium ion regulated exocytosis;negative regulation of cell proliferation;positive regulation of actin nucleation;positive regulation of apoptotic process;positive regulation of megakaryocyte differentiation;positive regulation of secretion;regulation of chondrocyte differentiation;sequestering of actin monomers","1-phosphatidylinositol binding;actin binding;actin filament binding;calcium ion binding;phosphatidylinositol-4,5-bisphosphate binding;phosphatidylserine binding","brush border;cell cortex;cell junction;cell projection;cytoplasm;extracellular exosome;podosome","Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Viral carcinogenesis",null,null,3,3,3,"5.6","5.6","5.6","80.488","0.0046872","2.8825",13401000,2,"0.380977",1,"-7.59533","-1.0176","sp|Q9Y6U3|ADSV_HUMAN","sp|Q9Y6U3|ADSV_HUMAN",5114,"Q9Y6U3","ADSV_HUMAN","Adseverin",null,"SCIN"]
[1,"16.022","16.0763","16.1917",{"$nulls":3},"mitochondrial translational initiation;regulation of translational initiation;ribosome disassembly","GTP binding;GTPase activity;ribosomal small subunit binding;RNA binding;translation factor activity, RNA binding;translation initiation factor activity","mitochondrion;nucleoplasm",{"$nulls":3},2,2,2,"4.8","4.8","4.8","81.316","0.00067919","4.3382",11854000,5,"0.379899",1,"-7.62296","-1.01488","sp|P46199|IF2M_HUMAN;tr|H7C213|H7C213_HUMAN","sp|P46199|IF2M_HUMAN;tr|H7C213|H7C213_HUMAN",1508,"P46199","IF2M_HUMAN","Translation initiation factor IF-2, mitochondrial","F2(mt);F-2(Mt);F-2Mt","MTIF2"]
["16.6237",1,"17.7943","15.0788",{"$nulls":5},"tRNA-splicing ligase complex",{"$nulls":3},3,3,3,"15.5","15.5","15.5","37.329",0,"8.1798",21921000,5,"0.358818",1,"-7.6247","-0.961626","sp|Q17RN3|FA98C_HUMAN;tr|K7EQL1|K7EQL1_HUMAN;tr|K7EQT7|K7EQT7_HUMAN","sp|Q17RN3|FA98C_HUMAN;tr|K7EQL1|K7EQL1_HUMAN;tr|K7EQT7|K7EQT7_HUMAN",2583,"Q17RN3","FA98C_HUMAN","Protein FAM98C",null,"FAM98C"]
["16.0273",1,"16.9938","15.2831",{"$nulls":3},"apoptotic process;cell proliferation;G2/M transition of mitotic cell cycle;hemopoiesis;intracellular signal transduction;intrinsic apoptotic signaling pathway in response to oxidative stress;neural precursor cell proliferation;positive regulation of apoptotic process;protein autophosphorylation","ATP binding;calcium ion binding;lipid binding;non-membrane spanning protein tyrosine kinase activity;protein serine/threonine kinase activity","cell cortex;membrane;nucleus;plasma membrane",{"$nulls":3},11,11,11,"22.4","22.4","22.4","74.641",0,"30.751",221210000,45,"0.377293",1,"-7.62479","-1.00828","sp|Q14680|MELK_HUMAN;tr|A0A0D9SGI4|A0A0D9SGI4_HUMAN","sp|Q14680|MELK_HUMAN",2379,"Q14680","MELK_HUMAN","Maternal embryonic leucine zipper kinase","MELK","MELK"]
["15.6605",1,"15.947","15.9701",{"$nulls":3},"regulation of actin cytoskeleton organization;regulation of actin filament polymerization;regulation of cell motility;regulation of cell shape;regulation of small GTPase mediated signal transduction;small GTPase mediated signal transduction","cadherin binding;GTPase activator activity","cytoplasm;cytosol;nuclear speck;plasma membrane",{"$nulls":3},2,2,2,"3.9","3.9","3.9","74.976","0.00024237","5.7134",32330000,4,"0.390068",1,"-7.62827","-1.04065","sp|Q8N392|RHG18_HUMAN","sp|Q8N392|RHG18_HUMAN",3212,"Q8N392","RHG18_HUMAN","Rho GTPase-activating protein 18",null,"ARHGAP18"]
["16.4973",1,"16.5353","16.2366",{"$nulls":3},"mRNA methylation;tRNA methylation;tRNA modification","RNA binding","nucleoplasm;tRNA (m1A) methyltransferase complex",{"$nulls":3},3,3,3,"8.5","8.5","8.5","55.799",0,"10.688",32250000,7,"0.368259",1,"-7.63729","-0.985443","sp|Q9UJA5|TRM6_HUMAN","sp|Q9UJA5|TRM6_HUMAN",4763,"Q9UJA5","TRM6_HUMAN","tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6",null,"TRMT6"]
["17.8377",1,"18.0751","16.0706",{"$nulls":3},"actin cytoskeleton organization;actin filament bundle assembly;anatomical structure morphogenesis;cell migration;cell motility;cell proliferation;cell-cell junction assembly;establishment of apical/basal cell polarity;microspike assembly;positive regulation of extracellular matrix disassembly;positive regulation of filopodium assembly;positive regulation of lamellipodium assembly;positive regulation of podosome assembly;regulation of actin cytoskeleton organization;regulation of microvillus assembly","actin binding;actin filament binding;cadherin binding;drug binding;protein binding, bridging;RNA binding","actin cytoskeleton;cell projection membrane;cell-cell junction;cytoplasm;cytoskeleton;cytosol;extracellular exosome;filamentous actin;filopodium;growth cone;invadopodium;lamellipodium;microspike;microvillus;myelin sheath;podosome;ruffle;stress fiber","MicroRNAs in cancer",null,null,4,4,4,"11.4","11.4","11.4","54.529",0,"8.8767",71763000,12,"0.335427",1,"-7.65402","-0.902779","sp|Q16658|FSCN1_HUMAN;tr|C9JPH9|C9JPH9_HUMAN;tr|C9JFC0|C9JFC0_HUMAN;tr|A0A0A0MSB2|A0A0A0MSB2_HUMAN","sp|Q16658|FSCN1_HUMAN",2561,"Q16658","FSCN1_HUMAN","Fascin",null,"FSCN1"]
["16.4168",1,"16.8295","15.8997",{"$nulls":3},"heme biosynthetic process","ferrochelatase activity",{"$nulls":4},2,2,2,"10.4","10.4","10.4","37.01",0,"11.452",39796000,3,"0.370628",1,"-7.6562","-0.991429","tr|K7ELX4|K7ELX4_HUMAN;sp|P22830|HEMH_HUMAN;tr|K7EJM8|K7EJM8_HUMAN;tr|K7EJX5|K7EJX5_HUMAN;tr|K7EKP7|K7EKP7_HUMAN","tr|K7ELX4|K7ELX4_HUMAN;sp|P22830|HEMH_HUMAN;tr|K7EJM8|K7EJM8_HUMAN;tr|K7EJX5|K7EJX5_HUMAN;tr|K7EKP7|K7EKP7_HUMAN",1188,"K7ELX4","K7ELX4_HUMAN",null,null,"FECH"]
["15.7355",1,"16.6718","15.404",{"$nulls":3},"mRNA processing;regulation of alternative mRNA splicing, via spliceosome;RNA splicing",null,"cytoplasm;nuclear speck",{"$nulls":3},3,3,3,"7.4","7.4","7.4","57.543","0.00024777","6.1811",26539000,2,"0.388708",1,"-7.6701","-1.0372","sp|Q2TAY7|SMU1_HUMAN","sp|Q2TAY7|SMU1_HUMAN",2604,"Q2TAY7","SMU1_HUMAN","WD40 repeat-containing protein SMU1",null,"SMU1"]
[1,"18.6445","17.1596","17.8528",{"$nulls":3},"angiogenesis;signal transduction","receptor tyrosine kinase binding",{"$nulls":4},3,3,3,"18.5","18.5","18.5","32.507",0,"8.4126",50375000,10,"0.322487",1,"-7.68391","-0.870299","tr|H0Y539|H0Y539_HUMAN;tr|X6R6D0|X6R6D0_HUMAN;sp|P29353|SHC1_HUMAN;tr|Q5T188|Q5T188_HUMAN","tr|H0Y539|H0Y539_HUMAN;tr|X6R6D0|X6R6D0_HUMAN;sp|P29353|SHC1_HUMAN",1283,"H0Y539","H0Y539_HUMAN",null,null,"SHC1"]
["17.6298",1,"17.3618","16.6472",{"$nulls":9},2,2,2,"10.1","10.1","10.1","27.637","0.00069477","4.7531",15219000,4,"0.343851",1,"-7.68963","-0.92395","tr|C9J2Z9|C9J2Z9_HUMAN;sp|O15047|SET1A_HUMAN","tr|C9J2Z9|C9J2Z9_HUMAN;sp|O15047|SET1A_HUMAN",317,"C9J2Z9","C9J2Z9_HUMAN",null,null,"SETD1A"]
[1,"15.8092","15.9088","16.2985",{"$nulls":3},"anatomical structure morphogenesis;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;cellular response to cadmium ion;cellular response to reactive oxygen species;cellular response to tumor necrosis factor;cellular response to virus;Fc-epsilon receptor signaling pathway;I-kappaB kinase/NF-kappaB signaling;I-kappaB phosphorylation;immune response;inflammatory response;innate immune response;MyD88-independent toll-like receptor signaling pathway;negative regulation of NF-kappaB transcription factor activity;NIK/NF-kappaB signaling;nucleotide-binding oligomerization domain containing signaling pathway;peptidyl-serine phosphorylation;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of interferon-alpha secretion;positive regulation of NF-kappaB transcription factor activity;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription, DNA-templated;protein kinase B signaling;protein phosphorylation;regulation of tumor necrosis factor-mediated signaling pathway;response to acetate;response to amino acid;response to drug;response to hydroperoxide;response to lipopolysaccharide;response to toxic substance;response to virus;Rho protein signal transduction;skeletal muscle contraction;stimulatory C-type lectin receptor signaling pathway;stress-activated MAPK cascade;striated muscle cell differentiation;T cell receptor signaling pathway;TRIF-dependent toll-like receptor signaling pathway;tumor necrosis factor-mediated signaling pathway","ATP binding;IkappaB kinase activity;protein heterodimerization activity;protein homodimerization activity;protein kinase activity;scaffold protein binding","CD40 receptor complex;cytoplasm;cytoplasmic side of plasma membrane;cytosol;IkappaB kinase complex;intracellular membrane-bounded organelle;nucleoplasm","Acute myeloid leukemia;Adipocytokine signaling pathway;Antifolate resistance;Apoptosis;B cell receptor signaling pathway;Chagas disease (American trypanosomiasis);Chemokine signaling pathway;Chronic myeloid leukemia;C-type lectin receptor signaling pathway;Cytosolic DNA-sensing pathway;Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;Fluid shear stress and atherosclerosis;FoxO signaling pathway;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Human T-cell leukemia virus 1 infection;IL-17 signaling pathway;Influenza A;Kaposi sarcoma-associated herpesvirus infection;MAPK signaling pathway;Measles;mTOR signaling pathway;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Osteoclast differentiation;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Prostate cancer;Ras signaling pathway;RIG-I-like receptor signaling pathway;Shigellosis;Small cell lung cancer;T cell receptor signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Yersinia infection",null,null,1,1,1,"2.1","2.1","2.1","84.639","0.0050363","2.7449",14410000,0,"0.389574",1,"-7.69904","-1.0394","sp|O15111|IKKA_HUMAN","sp|O15111|IKKA_HUMAN",323,"O15111","IKKA_HUMAN","Inhibitor of nuclear factor kappa-B kinase subunit alpha","kappaB kinase;-kappa-B kinase alpha;kBKA;KK-A;KK-alpha","CHUK"]
["16.8139",1,"16.7651","16.4533",{"$nulls":3},"apoptotic process;axonal transport of mitochondrion;cellular response to glucose stimulus;cellular response to hypoxia;cellular response to L-glutamate;cellular senescence;cochlea development;dynamin family protein polymerization involved in mitochondrial fission;GTP metabolic process;inner mitochondrial membrane organization;intracellular distribution of mitochondria;membrane tubulation;mitochondrial calcium uptake;mitochondrial fission;mitochondrial fusion;mitochondrial genome maintenance;mitochondrion morphogenesis;mitochondrion organization;negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;negative regulation of release of cytochrome c from mitochondria;positive regulation of dendritic spine morphogenesis;positive regulation of glucose import in response to insulin stimulus;positive regulation of mitochondrial fusion;positive regulation of neuron maturation;protein oligomerization;regulation of apoptotic process;response to electrical stimulus;response to muscle activity;response to nutrient levels;retina development in camera-type eye;visual perception","cardiolipin binding;GTP binding;GTPase activity;kinase binding;magnesium ion binding;microtubule binding;phosphatidic acid binding","axon cytoplasm;cytosol;dendrite;extrinsic component of mitochondrial inner membrane;integral component of membrane;membrane;mitochondrial crista;mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial outer membrane;mitochondrion;nucleoplasm",{"$nulls":3},25,1,1,"34.2","1.5","1.5","111.63","0.0036953","2.9739",32980000,1,"0.363694",1,"-7.70226","-0.973923","sp|O60313|OPA1_HUMAN;tr|C9JY58|C9JY58_HUMAN","sp|O60313|OPA1_HUMAN",463,"O60313","OPA1_HUMAN","Dynamin-like 120 kDa protein, mitochondrial",null,"OPA1"]
[1,"17.0705","15.8022","17.6789",{"$nulls":3},"endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);hematopoietic progenitor cell differentiation;mitotic metaphase plate congression;protein localization to nucleolus;regulation of signal transduction by p53 class mediator;ribosomal large subunit assembly;ribosomal large subunit biogenesis;ribosomal large subunit export from nucleus","5S rRNA binding;RNA binding","condensed nuclear chromosome;endoplasmic reticulum;fibrillar center;nucleolus;nucleus;preribosome, large subunit precursor",{"$nulls":3},3,3,3,"10.7","10.7","10.7","41.193",0,"26.547",79999000,9,"0.35518",1,"-7.70527","-0.952459","sp|Q15050|RRS1_HUMAN","sp|Q15050|RRS1_HUMAN",2438,"Q15050","RRS1_HUMAN","Ribosome biogenesis regulatory protein homolog",null,"RRS1"]
["17.2417",1,"17.0091","16.6447",{"$nulls":3},"cellular protein modification process;endocytosis;peptidyl-serine phosphorylation;regulation of cell shape;signal transduction;Wnt signaling pathway","ATP binding;protein kinase activity;protein serine/threonine kinase activity","cytoplasm;nucleus","Hedgehog signaling pathway",null,null,9,9,1,"22.6","22.6","3.8","51.388",0,"16.757",159940000,27,"0.353679",1,"-7.70603","-0.948679","sp|Q9Y6M4|KC1G3_HUMAN;tr|K7ESB6|K7ESB6_HUMAN;tr|A0A087WWF5|A0A087WWF5_HUMAN;tr|A0A087WZK4|A0A087WZK4_HUMAN;tr|A0A087WXD7|A0A087WXD7_HUMAN;tr|K7EP38|K7EP38_HUMAN","sp|Q9Y6M4|KC1G3_HUMAN",5105,"Q9Y6M4","KC1G3_HUMAN","Casein kinase I isoform gamma-3","KI-gamma 3","CSNK1G3"]
["17.8792",1,"17.3699","16.9492",{"$nulls":3},"early endosome to Golgi transport;endocytosis;intracellular protein transport;vesicle organization","identical protein binding;phosphatidylinositol binding","cytosol;early endosome membrane;extrinsic component of membrane;intracellular membrane-bounded organelle",{"$nulls":3},4,4,4,11,11,11,"52.569",0,"10.651",72041000,12,"0.340071",1,"-7.71996","-0.914446","sp|Q9Y5X2|SNX8_HUMAN;tr|C9J8E6|C9J8E6_HUMAN;tr|C9J014|C9J014_HUMAN;tr|C9J271|C9J271_HUMAN;tr|C9IYC5|C9IYC5_HUMAN;tr|C9JCB9|C9JCB9_HUMAN","sp|Q9Y5X2|SNX8_HUMAN;tr|C9J8E6|C9J8E6_HUMAN;tr|C9J014|C9J014_HUMAN;tr|C9J271|C9J271_HUMAN",5061,"Q9Y5X2","SNX8_HUMAN","Sorting nexin-8",null,"SNX8"]
["17.0522",1,"16.6527","16.8669",{"$nulls":4},"protein-cysteine S-palmitoyltransferase activity","integral component of membrane",{"$nulls":3},3,3,3,"16.8","16.8","16.8","33.743","0.00026759","7.8317",21084000,6,"0.359555",1,"-7.73371","-0.963485","tr|B4DRN8|B4DRN8_HUMAN;sp|Q5W0Z9|ZDH20_HUMAN","tr|B4DRN8|B4DRN8_HUMAN;sp|Q5W0Z9|ZDH20_HUMAN",2774,"B4DRN8","B4DRN8_HUMAN","Palmitoyltransferase {ECO:0000256|RuleBase:RU079119}",null,"ZDHHC20"]
["15.9726",1,"16.385","16.1085",{"$nulls":3},"arachidonic acid metabolic process;arachidonic acid secretion;cardiolipin acyl-chain remodeling;cellular response to antibiotic;icosanoid biosynthetic process;icosanoid metabolic process;phosphatidic acid biosynthetic process;phosphatidylcholine acyl-chain remodeling;phosphatidylethanolamine acyl-chain remodeling;phosphatidylglycerol acyl-chain remodeling;phosphatidylinositol acyl-chain remodeling;phosphatidylserine acyl-chain remodeling;phospholipid catabolic process;phospholipid metabolic process;platelet activating factor biosynthetic process;regulation of cell proliferation","calcium ion binding;calcium-dependent phospholipase A2 activity;calcium-dependent phospholipid binding;lysophospholipase activity;phosphatidylcholine 1-acylhydrolase activity;phospholipase A2 activity;phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine);phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)","cytoplasmic vesicle;cytosol;endoplasmic reticulum membrane;Golgi apparatus;lipid droplet;mitochondrial inner membrane","alpha-Linolenic acid metabolism;Arachidonic acid metabolism;Choline metabolism in cancer;Ether lipid metabolism;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Glutamatergic synapse;Glycerophospholipid metabolism;GnRH signaling pathway;Inflammatory mediator regulation of TRP channels;Linoleic acid metabolism;Long-term depression;MAPK signaling pathway;Metabolic pathways;Necroptosis;Ovarian steroidogenesis;Oxytocin signaling pathway;Phospholipase D signaling pathway;Platelet activation;Ras signaling pathway;Serotonergic synapse;Vascular smooth muscle contraction;VEGF signaling pathway",null,null,2,2,2,"4.8","4.8","4.8","85.238","0.00068012","4.3584",16074000,4,"0.388409",1,"-7.76043","-1.03644","sp|P47712|PA24A_HUMAN","sp|P47712|PA24A_HUMAN",1526,"P47712","PA24A_HUMAN","Cytosolic phospholipase A2","PLA2","PLA2G4A"]
["18.267",1,"19.4606","15.4764",{"$nulls":3},"extrinsic apoptotic signaling pathway via death domain receptors;mRNA processing;RNA secondary structure unwinding;RNA splicing;rRNA processing","ATP binding;ATP-dependent RNA helicase activity;RNA binding","cytoplasm;membrane;nucleolus;nucleoplasm",{"$nulls":3},14,14,14,"36.3","36.3","36.3","50.646",0,"121.57",990310000,96,"0.328059",1,"-7.83502","-0.884281","sp|Q9H0S4|DDX47_HUMAN;tr|F5H1N9|F5H1N9_HUMAN","sp|Q9H0S4|DDX47_HUMAN",4143,"Q9H0S4","DDX47_HUMAN","Probable ATP-dependent RNA helicase DDX47",null,"DDX47"]
["16.7336",1,"17.391","16.0365",{"$nulls":3},"rRNA processing;spliceosomal snRNP assembly",null,"cytosol;nuclear body;SMN complex",{"$nulls":3},17,17,17,"21.8","21.8","21.8","118.82",0,"89.834",371480000,36,"0.371566",1,"-7.84692","-0.993799","tr|I3L2C7|I3L2C7_HUMAN;sp|P57678|GEMI4_HUMAN;tr|I3L399|I3L399_HUMAN;tr|I3L4A4|I3L4A4_HUMAN;tr|E7EN12|E7EN12_HUMAN;tr|I3L4M4|I3L4M4_HUMAN","tr|I3L2C7|I3L2C7_HUMAN;sp|P57678|GEMI4_HUMAN",1793,"I3L2C7","I3L2C7_HUMAN",null,null,"GEMIN4"]
["16.6293",1,"16.7444","16.6716",{"$nulls":9},5,5,5,"6.4","6.4","6.4","117.13",0,"11.847",82909000,7,"0.377998",1,"-7.89337","-1.01006","sp|Q9Y2H5|PKHA6_HUMAN;tr|Q5VTI5|Q5VTI5_HUMAN","sp|Q9Y2H5|PKHA6_HUMAN;tr|Q5VTI5|Q5VTI5_HUMAN",4916,"Q9Y2H5","PKHA6_HUMAN","Pleckstrin homology domain-containing family A member 6","H domain-containing family A member 6","PLEKHA6"]
["15.9268",1,"16.5042","16.244",{"$nulls":3},"mitochondrial ornithine transport;mitochondrial transport;urea cycle","L-ornithine transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane",{"$nulls":3},3,3,3,"12.3","12.3","12.3","32.736","0.00024284","5.7389",32086000,4,"0.397587",1,"-7.91064","-1.05976","sp|Q9Y619|ORNT1_HUMAN;tr|Q5VZD9|Q5VZD9_HUMAN","sp|Q9Y619|ORNT1_HUMAN",5073,"Q9Y619","ORNT1_HUMAN","Mitochondrial ornithine transporter 1",null,"SLC25A15"]
["16.4742",1,"16.953","16.4219",{"$nulls":5},"integral component of membrane",{"$nulls":3},5,5,5,"6.9","6.9","6.9","128.57",0,"14.408",129280000,17,"0.384666",1,"-7.95034","-1.02695","sp|Q68CR1|SE1L3_HUMAN","sp|Q68CR1|SE1L3_HUMAN",2791,"Q68CR1","SE1L3_HUMAN","Protein sel-1 homolog 3",null,"SEL1L3"]
["17.6454",1,"17.9753","16.6328",{"$nulls":3},"cellular respiration;mitochondrial large ribosomal subunit assembly","protein kinase activity;RNA binding;rRNA binding","intercellular bridge;mitochondrial nucleoid;mitochondrion;nucleus;ribonucleoprotein granule",{"$nulls":3},5,5,5,"10.6","10.6","10.6","81.462",0,"15.406",108920000,14,"0.356539",1,"-7.98138","-0.955885","sp|Q9NYY8|FAKD2_HUMAN","sp|Q9NYY8|FAKD2_HUMAN",4577,"Q9NYY8","FAKD2_HUMAN","FAST kinase domain-containing protein 2, mitochondrial",null,"FASTKD2"]
["13.9824",1,"14.3354","16.7215",{"$nulls":3},"cell division;centrosome localization;flagellated sperm motility;mitotic spindle organization;protein localization to nuclear envelope;regulation of fertilization;regulation of mitotic cell cycle;snRNA transcription from RNA polymerase II promoter",null,"cytoplasm;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"3.8","3.8","3.8","80.224","0.00488","2.8541",11180000,2,"0.459069",1,"-8.03725","-1.21778","sp|Q9NVM9|ASUN_HUMAN;tr|H0YH12|H0YH12_HUMAN","sp|Q9NVM9|ASUN_HUMAN;tr|H0YH12|H0YH12_HUMAN",4495,"Q9NVM9","INT13_HUMAN","Integrator complex subunit 13 {ECO:0000312|HGNC:HGNC:20174}",null,"INTS13"]
["16.8589",1,"17.2986","16.6455",{"$nulls":3},"aging;cellular response to cAMP;cellular response to fructose stimulus;cellular response to glucagon stimulus;cellular response to hypoxia;cellular response to insulin stimulus;cellular response to interleukin-1;cellular response to potassium ion starvation;cellular response to retinoic acid;cellular response to tumor necrosis factor;gluconeogenesis;glucose homeostasis;glucose metabolic process;glycerol biosynthetic process from pyruvate;internal protein amino acid acetylation;oxaloacetate metabolic process;positive regulation of transcription from RNA polymerase II promoter in response to acidic pH;response to activity;response to insulin;response to interleukin-6;response to lipopolysaccharide;response to methionine","carboxylic acid binding;GDP binding;GTP binding;magnesium ion binding;manganese ion binding;phosphoenolpyruvate carboxykinase (GTP) activity","cytoplasm;cytosol;extracellular exosome","Adipocytokine signaling pathway;AMPK signaling pathway;Citrate cycle (TCA cycle);FoxO signaling pathway;Glucagon signaling pathway;Glycolysis / Gluconeogenesis;Insulin resistance;Insulin signaling pathway;Metabolic pathways;PI3K-Akt signaling pathway;PPAR signaling pathway;Proximal tubule bicarbonate reclamation;Pyruvate metabolism",null,null,2,1,1,5,"2.3","2.3","69.194","0.00069428","4.7407",18997000,4,"0.379321",1,"-8.04261","-1.01341","sp|P35558|PCKGC_HUMAN","sp|P35558|PCKGC_HUMAN",1387,"P35558","PCKGC_HUMAN","Phosphoenolpyruvate carboxykinase, cytosolic [GTP]","EPCK-C","PCK1"]
["15.9119",1,"16.5086","16.4993",{"$nulls":3},"negative regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of translation;response to endoplasmic reticulum stress",null,"cytoplasm;cytosol;extracellular exosome;membrane;plasma membrane",{"$nulls":3},1,1,1,"1.4","1.4","1.4","103.13","0.00026344","7.4537",23000000,5,"0.405302",1,"-8.04801","-1.07941","sp|Q9BZQ8|NIBAN_HUMAN","sp|Q9BZQ8|NIBAN_HUMAN",4086,"Q9BZQ8","NIBAN_HUMAN","Protein Niban",null,"FAM129A"]
["17.7862",1,"17.6321","17.2825",{"$nulls":3},"chromatin remodeling;negative regulation of transcription, DNA-templated;peptidyl-arginine hydroxylation;ribosome biogenesis;transcription, DNA-templated","histone demethylase activity;histone demethylase activity (H3-K36 specific);histone demethylase activity (H3-K4 specific);identical protein binding;metal ion binding;transcriptional repressor activity, RNA polymerase II transcription factor binding","cytosol;nucleolus;nucleoplasm;nucleus;transcription factor complex",{"$nulls":3},3,3,3,"10.8","10.8","10.8","52.8","0.00023866","5.3885",36180000,3,"0.358411",1,"-8.06418","-0.960602","sp|Q8IUF8|MINA_HUMAN;tr|D6RCB6|D6RCB6_HUMAN;tr|H0Y9L8|H0Y9L8_HUMAN","sp|Q8IUF8|MINA_HUMAN;tr|D6RCB6|D6RCB6_HUMAN",3103,"Q8IUF8","RIOX2_HUMAN","Ribosomal oxygenase 2 {ECO:0000312|HGNC:HGNC:19441}",null,"RIOX2"]
[1,"18.5669","17.9453","17.7584",{"$nulls":9},1,1,1,"5.7","5.7","5.7","24.322","0.00087912","3.9302",25777000,1,"0.341698",1,"-8.06838","-0.918535","tr|B7ZBC9|B7ZBC9_HUMAN;tr|B7ZBC8|B7ZBC8_HUMAN;sp|O75449|KTNA1_HUMAN","tr|B7ZBC9|B7ZBC9_HUMAN;tr|B7ZBC8|B7ZBC8_HUMAN;sp|O75449|KTNA1_HUMAN",573,"B7ZBC9","B7ZBC9_HUMAN",null,null,"KATNA1"]
[1,"17.3557","17.0777","17.4621",{"$nulls":3},"phosphatidylinositol biosynthetic process;phosphatidylinositol dephosphorylation;regulation of phosphatidylinositol dephosphorylation","phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;phosphatidylinositol-3-phosphatase activity;protein homodimerization activity;protein tyrosine phosphatase activity","cytoplasm;cytosol;plasma membrane","Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system",null,null,16,16,16,"29.8","29.8","29.8","74.677",0,"38.023",423030000,58,"0.369759",1,"-8.09204","-0.989234","sp|Q13613|MTMR1_HUMAN;tr|F8WA39|F8WA39_HUMAN;tr|Q8NEC6|Q8NEC6_HUMAN;tr|H0YDX3|H0YDX3_HUMAN;tr|E9PIH9|E9PIH9_HUMAN;tr|E9PPP8|E9PPP8_HUMAN;tr|H7BZJ1|H7BZJ1_HUMAN;tr|H7C406|H7C406_HUMAN;tr|F8W764|F8W764_HUMAN;tr|F8W8S8|F8W8S8_HUMAN","sp|Q13613|MTMR1_HUMAN;tr|F8WA39|F8WA39_HUMAN;tr|Q8NEC6|Q8NEC6_HUMAN;tr|H0YDX3|H0YDX3_HUMAN",2290,"Q13613","MTMR1_HUMAN","Myotubularin-related protein 1",null,"MTMR1"]
["18.5544",1,"18.829","16.9333",{"$nulls":4},"zinc ion binding",{"$nulls":4},4,4,4,"13.5","13.5","13.5","42.542",0,"12.35",53547000,12,"0.341469",1,"-8.10396","-0.91796","tr|H7C0E5|H7C0E5_HUMAN;sp|O75312|ZPR1_HUMAN;tr|H7BZM7|H7BZM7_HUMAN","tr|H7C0E5|H7C0E5_HUMAN;sp|O75312|ZPR1_HUMAN;tr|H7BZM7|H7BZM7_HUMAN",543,"H7C0E5","H7C0E5_HUMAN",null,null,"ZPR1"]
[1,"17.8221","18.4755","16.5834",{"$nulls":3},"aging;apoptotic process;behavioral fear response;cell migration;cellular response to dexamethasone stimulus;cellular response to growth factor stimulus;cellular response to insulin stimulus;G1/S transition of mitotic cell cycle;germ cell development;long-term memory;negative regulation of apoptotic process;negative regulation of extrinsic apoptotic signaling pathway;negative regulation of insulin receptor signaling pathway;phosphatidylinositol-mediated signaling;positive regulation of mitotic cell cycle;positive regulation of skeletal muscle tissue growth;positive regulation of smooth muscle cell migration;positive regulation of smooth muscle cell proliferation;positive regulation of translation;positive regulation of translational initiation;protein kinase B signaling;regulation of glucose import;response to drug;response to electrical stimulus involved in regulation of muscle adaptation;response to ethanol;response to glucagon;response to glucose;response to heat;response to leucine;response to lipopolysaccharide;response to mechanical stimulus;response to nutrient;response to testosterone;response to toxic substance;response to tumor necrosis factor;response to wounding;signal transduction;skeletal muscle atrophy;skeletal muscle contraction;TOR signaling","ATP binding;identical protein binding;kinase activity;PDZ domain binding;peptide binding;protein kinase activity;protein phosphatase 2A binding;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;ribosomal protein S6 kinase activity","cell junction;cell surface;cytoplasm;cytosol;mitochondrial outer membrane;mitochondrion;neuron projection;nucleoplasm;nucleus;perinuclear region of cytoplasm;synapse","Acute myeloid leukemia;AMPK signaling pathway;Apelin signaling pathway;Autophagy - animal;Breast cancer;Choline metabolism in cancer;Colorectal cancer;EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;ErbB signaling pathway;Fc gamma R-mediated phagocytosis;Gastric cancer;Hepatocellular carcinoma;HIF-1 signaling pathway;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Insulin resistance;Insulin signaling pathway;Longevity regulating pathway;Longevity regulating pathway - multiple species;mTOR signaling pathway;Pancreatic cancer;Pathways in cancer;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Proteoglycans in cancer;TGF-beta signaling pathway;Thermogenesis",null,null,2,2,2,"6.3","6.3","6.3","59.139","0.0002656","7.6254",28390000,3,"0.35784",1,"-8.11841","-0.95916","sp|P23443|KS6B1_HUMAN","sp|P23443|KS6B1_HUMAN",1200,"P23443","KS6B1_HUMAN","Ribosomal protein S6 kinase beta-1","6K1;6K-beta-1","RPS6KB1"]
["17.8171",1,"18.2765","16.8062",{"$nulls":5},"membrane;nucleus",{"$nulls":3},3,3,3,2,2,2,"118.58","0.0085387","2.336",90117000,3,"0.359575",1,"-8.13284","-0.963536","sp|Q5M775|CYTSB_HUMAN;tr|J3KS18|J3KS18_HUMAN;tr|J3QSD6|J3QSD6_HUMAN;tr|J3KRD8|J3KRD8_HUMAN;tr|J3KRB9|J3KRB9_HUMAN;tr|J3KTI9|J3KTI9_HUMAN;tr|J3QRQ9|J3QRQ9_HUMAN;tr|J3QS22|J3QS22_HUMAN;tr|J3KSG2|J3KSG2_HUMAN","sp|Q5M775|CYTSB_HUMAN",2706,"Q5M775","CYTSB_HUMAN","Cytospin-B",null,"SPECC1"]
[1,"18.0949","17.1136","18.3123",{"$nulls":3},"cell proliferation;glucose metabolic process;hypoxia-inducible factor-1alpha signaling pathway;intrinsic apoptotic signaling pathway in response to oxidative stress;regulation of acetyl-CoA biosynthetic process from pyruvate;regulation of glucose metabolic process","ATP binding;protein kinase activity;pyruvate dehydrogenase (acetyl-transferring) kinase activity","mitochondrial matrix;mitochondrial pyruvate dehydrogenase complex;mitochondrion;nucleolus;nucleus","Axon guidance;Central carbon metabolism in cancer;HIF-1 signaling pathway",null,null,4,4,3,"13.5","13.5","10.3","49.244",0,"8.5693",45086000,6,"0.355384",1,"-8.16549","-0.952973","sp|Q15118|PDK1_HUMAN;tr|C9JKT3|C9JKT3_HUMAN;tr|C9IYB4|C9IYB4_HUMAN","sp|Q15118|PDK1_HUMAN",2451,"Q15118","PDK1_HUMAN","[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial",null,"PDK1"]
["18.8071",1,"18.8132","17.3656",{"$nulls":3},"apoptotic process;cellular response to oxidative stress;nucleobase-containing compound metabolic process","bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity;GTP binding","mitochondrial matrix","Metabolic pathways;Purine metabolism;Pyrimidine metabolism",null,null,4,4,4,32,32,32,"16.829","0.00023485","5.0427",25944000,3,"0.340839",1,"-8.18591","-0.916377","sp|P50583|AP4A_HUMAN","sp|P50583|AP4A_HUMAN",1632,"P50583","AP4A_HUMAN","Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]",null,"NUDT2"]
["17.0693",1,"16.2788","18.1654",{"$nulls":3},"muscle contraction","actin binding;calmodulin binding;PDZ domain binding;structural molecule activity","cytoplasm;cytoskeleton;dystrophin-associated glycoprotein complex;focal adhesion;protein complex;sarcolemma;synapse",{"$nulls":3},3,3,3,"10.8","10.8","10.8","58.06","0.00068839","4.5731",35471000,5,"0.378789",1,"-8.18744","-1.01207","sp|Q13884|SNTB1_HUMAN;tr|E5RIX7|E5RIX7_HUMAN","sp|Q13884|SNTB1_HUMAN",2311,"Q13884","SNTB1_HUMAN","Beta-1-syntrophin",null,"SNTB1"]
["18.4926",1,"18.0964","17.8012",{"$nulls":4},"metal ion binding","cytosol;plasma membrane",{"$nulls":3},2,2,2,16,16,16,"20.885","0.00069444","4.7464",24225000,5,"0.349315",1,"-8.2025","-0.937694","tr|A0A096LNV3|A0A096LNV3_HUMAN;tr|A0A096LP02|A0A096LP02_HUMAN;sp|Q9Y508|RN114_HUMAN;tr|A0A096LNT1|A0A096LNT1_HUMAN;tr|A0A096LNN8|A0A096LNN8_HUMAN;tr|A0A096LPF9|A0A096LPF9_HUMAN","tr|A0A096LNV3|A0A096LNV3_HUMAN;tr|A0A096LP02|A0A096LP02_HUMAN;sp|Q9Y508|RN114_HUMAN;tr|A0A096LNT1|A0A096LNT1_HUMAN;tr|A0A096LNN8|A0A096LNN8_HUMAN;tr|A0A096LPF9|A0A096LPF9_HUMAN",5026,"A0A096LNV3","A0A096LNV3_HUMAN",null,null,"RNF114"]
[1,"17.1324","17.3408","17.2565",{"$nulls":3},"cell division;protein ubiquitination",null,"Cul3-RING ubiquitin ligase complex",{"$nulls":3},1,1,1,"7.1","7.1","7.1","26.012","0.0088752","2.2702",7913000,4,"0.382159",1,"-8.23248","-1.0206","tr|C9J191|C9J191_HUMAN;sp|Q53GT1|KLH22_HUMAN","tr|C9J191|C9J191_HUMAN;sp|Q53GT1|KLH22_HUMAN",2655,"C9J191","C9J191_HUMAN",null,null,"KLHL22"]
[1,"21.1915","18.4974","20.1735",{"$nulls":3},"DNA recombination;double-strand break repair;protein deubiquitination;regulation of transcription, DNA-templated;transcription, DNA-templated;UV-damage excision repair",null,"cytoplasm;Ino80 complex;nucleoplasm;nucleus",{"$nulls":3},6,6,6,"19.9","19.9","19.9","68.297",0,"22.75",236150000,14,"0.299776",1,"-8.23968","-0.813354","sp|Q9H9F9|ARP5_HUMAN","sp|Q9H9F9|ARP5_HUMAN",4277,"Q9H9F9","ARP5_HUMAN","Actin-related protein 5","ARP5","ACTR5"]
["16.8301",1,"17.0644","17.2733",{"$nulls":3},"N-terminal peptidyl-methionine acetylation","peptide alpha-N-acetyltransferase activity","cytoplasm;cytosol;NatC complex;nucleus",{"$nulls":3},3,3,3,"11.3","11.3","11.3","39.319","0.00026267","7.419",21844000,8,"0.390878",1,"-8.25383","-1.04271","sp|Q147X3|NAA30_HUMAN;tr|J3KNC2|J3KNC2_HUMAN","sp|Q147X3|NAA30_HUMAN;tr|J3KNC2|J3KNC2_HUMAN",2397,"Q147X3","NAA30_HUMAN","N-alpha-acetyltransferase 30",null,"NAA30"]
["17.9047",1,"17.8833","17.6121",{"$nulls":5},"integral component of membrane",{"$nulls":3},1,1,1,"6.9","6.9","6.9","28.437","0.00067981","4.3513",7299000,4,"0.366618",1,"-8.29535","-0.981302","tr|E9PJ68|E9PJ68_HUMAN;sp|O75387|LAT3_HUMAN","tr|E9PJ68|E9PJ68_HUMAN;sp|O75387|LAT3_HUMAN",559,"E9PJ68","E9PJ68_HUMAN",null,null,"SLC43A1"]
[1,"16.6253","17.9801","16.2442",{"$nulls":3},"tRNA modification;tRNA thio-modification;tRNA wobble position uridine thiolation;tRNA wobble uridine modification","sulfurtransferase activity;tRNA binding","cytosol;protein complex","Sulfur relay system",null,null,3,3,3,"7.2","7.2","7.2","56.107","0.00023923","5.4188",23947000,8,"0.396038",1,"-8.29951","-1.05582","sp|Q2VPK5|CTU2_HUMAN;tr|H3BSW6|H3BSW6_HUMAN","sp|Q2VPK5|CTU2_HUMAN;tr|H3BSW6|H3BSW6_HUMAN",2606,"Q2VPK5","CTU2_HUMAN","Cytoplasmic tRNA 2-thiolation protein 2 {ECO:0000255|HAMAP-Rule:MF_03054}",null,"CTU2"]
["16.5542",1,"17.9582","16.1989",{"$nulls":3},"acylglycerol catabolic process;long term synaptic depression;negative regulation of cell migration;phospholipid catabolic process;positive regulation of lipid biosynthetic process;regulation of endocannabinoid signaling pathway","acylglycerol lipase activity;phospholipase activity","AMPA glutamate receptor complex;extracellular exosome;integral component of membrane;mitochondrion;plasma membrane","Retrograde endocannabinoid signaling",null,null,3,3,3,"11.3","11.3","11.3","38.33","0.00024073","5.5662",19518000,1,"0.397941",1,"-8.30148","-1.06066","sp|Q9BV23|ABHD6_HUMAN;tr|A0A087X2C5|A0A087X2C5_HUMAN;tr|C9JNE7|C9JNE7_HUMAN","sp|Q9BV23|ABHD6_HUMAN;tr|A0A087X2C5|A0A087X2C5_HUMAN",3997,"Q9BV23","ABHD6_HUMAN","Monoacylglycerol lipase ABHD6 {ECO:0000305}",null,"ABHD6"]
["17.4931",1,"17.2144","17.9098",{"$nulls":9},1,1,1,7,7,7,"26.937",0,"8.4946",18414000,6,"0.376972",1,"-8.31552","-1.00747","tr|H7BYW5|H7BYW5_HUMAN;tr|C9JSK5|C9JSK5_HUMAN;sp|P31321|KAP1_HUMAN","tr|H7BYW5|H7BYW5_HUMAN;tr|C9JSK5|C9JSK5_HUMAN;sp|P31321|KAP1_HUMAN",1328,"H7BYW5","H7BYW5_HUMAN",null,null,"PRKAR1B"]
["15.6462",1,"16.9076","16.3939",{"$nulls":3},"endoplasmic reticulum unfolded protein response;mannose trimming involved in glycoprotein ERAD pathway;N-glycan processing;protein glycosylation","calcium ion binding;mannosyl-oligosaccharide 1,2-alpha-mannosidase activity","endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum quality control compartment;membrane","Protein processing in endoplasmic reticulum",null,null,2,2,2,"2.7","2.7","2.7","104.66","0.00087989","3.9422",19400000,4,"0.427607",1,"-8.32768","-1.13648","sp|Q9BZQ6|EDEM3_HUMAN","sp|Q9BZQ6|EDEM3_HUMAN",4085,"Q9BZQ6","EDEM3_HUMAN","ER degradation-enhancing alpha-mannosidase-like protein 3",null,"EDEM3"]
[1,"17.6429","17.0313","18.3722",{"$nulls":9},2,2,2,21,21,21,"15.583","0.0023182","3.3545",7553900,1,"0.37553",1,"-8.38032","-1.00382","tr|H7C0A0|H7C0A0_HUMAN;tr|H7BZV3|H7BZV3_HUMAN;tr|C9JWL4|C9JWL4_HUMAN;tr|C9IZL5|C9IZL5_HUMAN;sp|O00189|AP4M1_HUMAN;tr|C9JC87|C9JC87_HUMAN;tr|C9JMG3|C9JMG3_HUMAN","tr|H7C0A0|H7C0A0_HUMAN;tr|H7BZV3|H7BZV3_HUMAN;tr|C9JWL4|C9JWL4_HUMAN;tr|C9IZL5|C9IZL5_HUMAN;sp|O00189|AP4M1_HUMAN;tr|C9JC87|C9JC87_HUMAN;tr|C9JMG3|C9JMG3_HUMAN",198,"H7C0A0","H7C0A0_HUMAN",null,null,"AP4M1"]
["19.0554",1,"19.8784","16.9821",{"$nulls":3},"apoptotic DNA fragmentation;nucleosome assembly","AT DNA binding;chromatin DNA binding;RNA binding","actin cytoskeleton;Golgi apparatus;nuclear body;nuclear chromatin;nuclear euchromatin;nucleoplasm;nucleosome;nucleus",{"$nulls":3},7,7,7,"27.8","27.8","27.8","20.863",0,"29.941",774170000,44,"0.341882",1,"-8.40253","-0.918999","sp|P07305|H10_HUMAN","sp|P07305|H10_HUMAN",894,"P07305","H10_HUMAN","Histone H1.0",null,"H1F0"]
[1,"18.1967","18.2977","17.7116",{"$nulls":4},"transferase activity, transferring glycosyl groups","endoplasmic reticulum membrane",{"$nulls":3},1,1,1,"7.7","7.7","7.7","24.198","0.00024432","5.8208",22187000,8,"0.364953",1,"-8.40632","-0.977098","tr|H0YCW6|H0YCW6_HUMAN;sp|Q9H6U8|ALG9_HUMAN;tr|A0A087WZ62|A0A087WZ62_HUMAN","tr|H0YCW6|H0YCW6_HUMAN;sp|Q9H6U8|ALG9_HUMAN;tr|A0A087WZ62|A0A087WZ62_HUMAN",4233,"H0YCW6","H0YCW6_HUMAN","Mannosyltransferase {ECO:0000256|RuleBase:RU363075}",null,"ALG9"]
["19.5615",1,"19.1555","18.2193",{"$nulls":9},1,1,1,"21.1","21.1","21.1","10.364","0.0050444","2.7562",16910000,1,"0.336175",1,"-8.4066","-0.904658","tr|A0A0A0MS96|A0A0A0MS96_HUMAN;tr|X6RJS7|X6RJS7_HUMAN;sp|P46736|BRCC3_HUMAN","tr|A0A0A0MS96|A0A0A0MS96_HUMAN;tr|X6RJS7|X6RJS7_HUMAN;sp|P46736|BRCC3_HUMAN",1512,"A0A0A0MS96","A0A0A0MS96_HUMAN",null,null,"BRCC3"]
["16.2839",1,"16.8012","17.3032",{"$nulls":3},"mRNA cis splicing, via spliceosome;mRNA splicing, via spliceosome","nucleic acid binding;proline-rich region binding;zinc ion binding","nuclear speck;nucleoplasm;spliceosomal complex",{"$nulls":3},2,2,2,"5.9","5.9","5.9","42.506","0.0099962","2.224",14034000,2,"0.413345",1,"-8.41025","-1.09994","sp|O75554|WBP4_HUMAN","sp|O75554|WBP4_HUMAN",586,"O75554","WBP4_HUMAN","WW domain-binding protein 4","BP-4","WBP4"]
["18.1101",1,"18.0871","17.9172",{"$nulls":4},"catalytic activity;iron-sulfur cluster binding",{"$nulls":4},2,2,2,"16.1","16.1","16.1","27.509","0.00024108","5.5933",23552000,4,"0.369006",1,"-8.44711","-0.987332","tr|D6RCP8|D6RCP8_HUMAN;sp|O43766|LIAS_HUMAN","tr|D6RCP8|D6RCP8_HUMAN;sp|O43766|LIAS_HUMAN",432,"D6RCP8","D6RCP8_HUMAN",null,null,"LIAS"]
["16.8956",1,"17.4306","17.3951",{"$nulls":3},"ribosomal large subunit biogenesis;rRNA processing",null,"cytoplasm;nucleolus",{"$nulls":3},2,2,2,"8.6","8.6","8.6","42.07","0.0002482","6.2172",18387000,5,"0.399679",1,"-8.4651","-1.06509","sp|Q9H6Y2|WDR55_HUMAN;tr|D6RGJ8|D6RGJ8_HUMAN","sp|Q9H6Y2|WDR55_HUMAN;tr|D6RGJ8|D6RGJ8_HUMAN",4236,"Q9H6Y2","WDR55_HUMAN","WD repeat-containing protein 55",null,"WDR55"]
["18.2014",1,"17.9476","18.1914",{"$nulls":3},"urea cycle","identical protein binding","cytosol;nucleus;perinuclear region of cytoplasm",{"$nulls":3},4,4,4,"23.7","23.7","23.7","33.344",0,"9.8625",87645000,14,"0.367912",1,"-8.46882","-0.984569","sp|Q9HBL8|NMRL1_HUMAN;tr|I3L3Z0|I3L3Z0_HUMAN;tr|I3L1Y8|I3L1Y8_HUMAN;tr|I3L543|I3L543_HUMAN;tr|I3L3I6|I3L3I6_HUMAN","sp|Q9HBL8|NMRL1_HUMAN;tr|I3L3Z0|I3L3Z0_HUMAN;tr|I3L1Y8|I3L1Y8_HUMAN;tr|I3L543|I3L543_HUMAN;tr|I3L3I6|I3L3I6_HUMAN",4312,"Q9HBL8","NMRL1_HUMAN","NmrA-like family domain-containing protein 1",null,"NMRAL1"]
[1,"19.1444","18.1895","18.9407",{"$nulls":3},"iron ion homeostasis","ion transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane",{"$nulls":3},2,2,2,"7.7","7.7","7.7","37.998",0,"11.521",115420000,18,"0.348379",1,"-8.49288","-0.935339","sp|Q6P4A7|SFXN4_HUMAN","sp|Q6P4A7|SFXN4_HUMAN",2867,"Q6P4A7","SFXN4_HUMAN","Sideroflexin-4",null,"SFXN4"]
["18.1306",1,"18.0207","18.1325",{"$nulls":3},"acyl-CoA metabolic process;CDP-diacylglycerol biosynthetic process;defense response to virus;fatty acid homeostasis;fatty acid metabolic process;interleukin-2 secretion;negative regulation of activation-induced cell death of T cells;phosphatidic acid biosynthetic process;phospholipid homeostasis;positive regulation of activated T cell proliferation;positive regulation of multicellular organism growth;regulation of cholesterol biosynthetic process;regulation of cytokine secretion;regulation of intracellular estrogen receptor signaling pathway;response to glucose;triglyceride biosynthetic process","glycerol-3-phosphate O-acyltransferase activity;sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity","integral component of membrane;mitochondrial inner membrane;mitochondrial outer membrane;plasma membrane","Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways",null,null,12,12,12,"25.2","25.2","25.2","93.794",0,"59.082",316010000,45,"0.371516",1,"-8.51127","-0.993672","sp|Q9HCL2|GPAT1_HUMAN;tr|Q5VW52|Q5VW52_HUMAN","sp|Q9HCL2|GPAT1_HUMAN;tr|Q5VW52|Q5VW52_HUMAN",4331,"Q9HCL2","GPAT1_HUMAN","Glycerol-3-phosphate acyltransferase 1, mitochondrial","PAT-1","GPAM"]
[1,"17.5285","17.8376","17.7262",{"$nulls":3},"activation of cysteine-type endopeptidase activity;activation of cysteine-type endopeptidase activity involved in apoptotic process;activation of innate immune response;apoptotic process;cellular response to interleukin-1;cellular response to lipopolysaccharide;cellular response to tumor necrosis factor;defense response to Gram-negative bacterium;defense response to virus;inflammatory response;innate immune response;interleukin-1 beta production;intrinsic apoptotic signaling pathway by p53 class mediator;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;macropinocytosis;myeloid dendritic cell activation;myeloid dendritic cell activation involved in immune response;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of interferon-beta production;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein serine/threonine kinase activity;neutrophil degranulation;positive regulation of actin filament polymerization;positive regulation of activated T cell proliferation;positive regulation of adaptive immune response;positive regulation of antigen processing and presentation of peptide antigen via MHC class II;positive regulation of apoptotic process;positive regulation of chemokine secretion;positive regulation of cysteine-type endopeptidase activity;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of defense response to virus by host;positive regulation of DNA binding transcription factor activity;positive regulation of ERK1 and ERK2 cascade;positive regulation of extrinsic apoptotic signaling pathway;positive regulation of interferon-gamma production;positive regulation of interleukin-1 beta secretion;positive regulation of interleukin-10 secretion;positive regulation of interleukin-6 production;positive regulation of interleukin-6 secretion;positive regulation of interleukin-8 secretion;positive regulation of JNK cascade;positive regulation of NF-kappaB transcription factor activity;positive regulation of phagocytosis;positive regulation of release of cytochrome c from mitochondria;positive regulation of T cell activation;positive regulation of T cell migration;positive regulation of tumor necrosis factor production;regulation of autophagy;regulation of GTPase activity;regulation of inflammatory response;regulation of intrinsic apoptotic signaling pathway;regulation of protein stability;regulation of tumor necrosis factor-mediated signaling pathway;signal transduction;tumor necrosis factor-mediated signaling pathway","BMP receptor binding;cysteine-type endopeptidase activator activity involved in apoptotic process;cysteine-type endopeptidase activity involved in apoptotic process;enzyme binding;identical protein binding;interleukin-6 receptor binding;ion channel binding;myosin I binding;protease binding;protein homodimerization activity;Pyrin domain binding;tropomyosin binding","AIM2 inflammasome complex;azurophil granule lumen;cytoplasm;cytosol;endoplasmic reticulum;extracellular region;IkappaB kinase complex;mitochondrion;neuronal cell body;NLRP1 inflammasome complex;NLRP3 inflammasome complex;nucleolus;nucleus;secretory granule lumen","C-type lectin receptor signaling pathway;Cytosolic DNA-sensing pathway;Influenza A;Legionellosis;Necroptosis;NOD-like receptor signaling pathway;Pertussis;Salmonella infection;Yersinia infection",null,null,2,2,2,"12.3","12.3","12.3","21.627","0.0085453","2.3435",19871000,3,"0.38612",1,"-8.51764","-1.03064","sp|Q9ULZ3|ASC_HUMAN","sp|Q9ULZ3|ASC_HUMAN",4831,"Q9ULZ3","ASC_HUMAN","Apoptosis-associated speck-like protein containing a CARD","ASC","PYCARD"]
[1,"16.7749","17.665","17.1633",{"$nulls":4},"hydrolase activity",{"$nulls":4},2,1,1,"11.1","5.6","5.6","21.809","0.0063656","2.6179",11975000,1,"0.405729",1,"-8.5267","-1.0805","tr|K7EIN2|K7EIN2_HUMAN;sp|Q9BRJ7|SDOS_HUMAN;tr|K7ENA3|K7ENA3_HUMAN","tr|K7EIN2|K7EIN2_HUMAN;sp|Q9BRJ7|SDOS_HUMAN;tr|K7ENA3|K7ENA3_HUMAN",3933,"K7EIN2","K7EIN2_HUMAN",null,null,"NUDT16L1"]
[1,"17.3704","18.8518","16.5944",{"$nulls":3},"heparan sulfate proteoglycan biosynthetic process;IRE1-mediated unfolded protein response;N-acetylglucosamine metabolic process;UDP-N-acetylgalactosamine metabolic process","alpha-1,4-N-acetylgalactosaminyltransferase activity;glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;glycosaminoglycan binding;manganese ion binding","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane","Glycosaminoglycan biosynthesis - heparan sulfate / heparin;Metabolic pathways",null,null,3,3,3,"12.4","12.4","12.4","37.465","0.00025419","6.7149",62277000,8,"0.387173",1,"-8.5379","-1.03331","sp|Q9UBQ6|EXTL2_HUMAN;tr|C9IYF5|C9IYF5_HUMAN;tr|F5GZK1|F5GZK1_HUMAN;tr|C9JEG3|C9JEG3_HUMAN","sp|Q9UBQ6|EXTL2_HUMAN;tr|C9IYF5|C9IYF5_HUMAN;tr|F5GZK1|F5GZK1_HUMAN;tr|C9JEG3|C9JEG3_HUMAN",4672,"Q9UBQ6","EXTL2_HUMAN","Exostosin-like 2",null,"EXTL2"]
["19.4934",1,"19.4817","18.0897",{"$nulls":3},"alcohol metabolic process;cellular ketone metabolic process;oxidation-reduction process;protein tetramerization;steroid metabolic process","3-keto sterol reductase activity;alcohol dehydrogenase [NAD(P)+] activity;carbonyl reductase (NADPH) activity;NADP-retinol dehydrogenase activity;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;receptor binding","endoplasmic reticulum membrane;extracellular exosome;mitochondrion;nucleus;peroxisomal membrane;peroxisome","Metabolic pathways;Peroxisome;Retinol metabolism",null,null,4,4,3,"21.9","21.9","18.7","29.537","0.00023855","5.3859",52853000,6,"0.342621",1,"-8.53898","-0.920858","sp|Q9BTZ2|DHRS4_HUMAN;tr|F5GWZ1|F5GWZ1_HUMAN;tr|F6TD35|F6TD35_HUMAN;tr|E9PFL3|E9PFL3_HUMAN;sp|Q6PKH6|DR4L2_HUMAN;tr|H0YN69|H0YN69_HUMAN;tr|D3YTE6|D3YTE6_HUMAN;tr|A0A087WXI8|A0A087WXI8_HUMAN","sp|Q9BTZ2|DHRS4_HUMAN;tr|F5GWZ1|F5GWZ1_HUMAN;tr|F6TD35|F6TD35_HUMAN;tr|E9PFL3|E9PFL3_HUMAN;sp|Q6PKH6|DR4L2_HUMAN;tr|H0YN69|H0YN69_HUMAN;tr|D3YTE6|D3YTE6_HUMAN",3976,"Q9BTZ2","DHRS4_HUMAN","Dehydrogenase/reductase SDR family member 4",null,"DHRS4"]
["19.5171",1,"19.9235","17.6949",{"$nulls":3},"cell-cell signaling;leukocyte migration;neutrophil degranulation;positive regulation of cell migration;positive regulation of cell proliferation;signal transduction",null,"anchored component of membrane;azurophil granule membrane;extracellular space;integral component of plasma membrane;plasma membrane",{"$nulls":3},3,3,2,"15.7","15.7","9.9","37.194",0,"28.815",58966000,7,"0.341054",1,"-8.5506","-0.916917","sp|P40199|CEAM6_HUMAN;tr|M0QYM2|M0QYM2_HUMAN","sp|P40199|CEAM6_HUMAN",1435,"P40199","CEAM6_HUMAN","Carcinoembryonic antigen-related cell adhesion molecule 6",null,"CEACAM6"]
["16.4938",1,"16.2232","18.3822",{"$nulls":3},"rRNA processing","RNA binding","nucleolus;nucleus;preribosome, large subunit precursor;preribosome, small subunit precursor",{"$nulls":3},10,10,10,"26.7","26.7","26.7","52.839",0,"63.911",1046100000,108,"0.41096",1,"-8.55581","-1.09385","sp|P56182|RRP1_HUMAN;tr|D6RE82|D6RE82_HUMAN","sp|P56182|RRP1_HUMAN",1777,"P56182","RRP1_HUMAN","Ribosomal RNA processing protein 1 homolog A",null,"RRP1"]
["17.4514",1,"17.2752","18.3273",{"$nulls":5},"extracellular exosome",{"$nulls":3},3,3,3,"17.3","17.3","17.3","23.297","0.0044944","2.9154",21178000,3,"0.389971",1,"-8.57557","-1.04041","sp|Q8NB37|PDDC1_HUMAN;tr|H0YER3|H0YER3_HUMAN;tr|H0YE25|H0YE25_HUMAN;tr|H0YF25|H0YF25_HUMAN;tr|E9PQD8|E9PQD8_HUMAN;tr|E9PLI5|E9PLI5_HUMAN","sp|Q8NB37|PDDC1_HUMAN;tr|H0YER3|H0YER3_HUMAN;tr|H0YE25|H0YE25_HUMAN;tr|H0YF25|H0YF25_HUMAN",3277,"Q8NB37","GALD1_HUMAN","Glutamine amidotransferase-like class 1 domain-containing protein 1 {ECO:0000312|HGNC:HGNC:26616}",null,"GATD1"]
["18.2886",1,"18.6193","17.8365",{"$nulls":3},"autophagosome assembly;macroautophagy;negative stranded viral RNA replication;protein homooligomerization;protein lipidation involved in autophagosome assembly;protein localization to phagophore assembly site;protein transport;xenophagy","GTPase binding;identical protein binding;ubiquitin-like protein transferase activity","autophagosome;autophagosome membrane;axoneme;cytosol;phagophore assembly site membrane","Autophagy - animal;Autophagy - other;NOD-like receptor signaling pathway",null,null,1,1,1,"1.8","1.8","1.8","68.264","0.00025272","6.5697",54662000,4,"0.370838",1,"-8.58359","-0.99196","sp|Q676U5|A16L1_HUMAN;tr|E7EVC7|E7EVC7_HUMAN","sp|Q676U5|A16L1_HUMAN;tr|E7EVC7|E7EVC7_HUMAN",2787,"Q676U5","A16L1_HUMAN","Autophagy-related protein 16-1",null,"ATG16L1"]
["17.8671",1,"17.7605","18.2838",{"$nulls":5},"extracellular space",{"$nulls":3},3,1,1,"17.5","7.9","7.9","21.846","0.00068337","4.4258",7022400,3,"0.38109",1,"-8.58859","-1.01789","tr|H7BXK7|H7BXK7_HUMAN;sp|P50452|SPB8_HUMAN;tr|C9JVA8|C9JVA8_HUMAN","tr|H7BXK7|H7BXK7_HUMAN;sp|P50452|SPB8_HUMAN;tr|C9JVA8|C9JVA8_HUMAN",1625,"H7BXK7","H7BXK7_HUMAN",null,null,"SERPINB8"]
[1,"20.4605","19.5879","19.0828",{"$nulls":3},"protein K69-linked ufmylation;protein ufmylation;response to endoplasmic reticulum stress","UFM1 transferase activity","cytoplasm;extracellular exosome",{"$nulls":3},2,2,2,"10.8","10.8","10.8","19.458","0.0036969","2.9758",37055000,5,"0.327973",1,"-8.60507","-0.884063","sp|Q9Y3C8|UFC1_HUMAN","sp|Q9Y3C8|UFC1_HUMAN",4982,"Q9Y3C8","UFC1_HUMAN","Ubiquitin-fold modifier-conjugating enzyme 1","fm1-conjugating enzyme 1","UFC1"]
["18.503",1,"19.2703","17.4804",{"$nulls":3},"cellular protein modification process;endomitotic cell cycle;negative regulation of transcription, DNA-templated;NIK/NF-kappaB signaling;post-translational protein modification;protein neddylation;proteolysis;regulation of cell cycle","acid-amino acid ligase activity;ATP binding;identical protein binding;ligand-dependent nuclear receptor binding;NEDD8 activating enzyme activity;NEDD8 transferase activity;protein heterodimerization activity","cytoplasm;cytosol;nucleus","Ubiquitin mediated proteolysis",null,null,6,6,6,"14.7","14.7","14.7","51.852",0,"39.638",97119000,15,"0.366218",1,"-8.62379","-0.980293","sp|Q8TBC4|UBA3_HUMAN;tr|F8W8D4|F8W8D4_HUMAN;tr|F8WF86|F8WF86_HUMAN","sp|Q8TBC4|UBA3_HUMAN;tr|F8W8D4|F8W8D4_HUMAN",3366,"Q8TBC4","UBA3_HUMAN","NEDD8-activating enzyme E1 catalytic subunit",null,"UBA3"]
["13.456",1,"14.5433","17.2474",{"$nulls":3},"cell redox homeostasis",null,"cytosol;integral component of membrane",{"$nulls":3},10,10,10,"16.6","16.6","16.6","90.59",0,"31.792",184260000,44,"0.513082",1,"-8.66735","-1.36","sp|Q9Y2G8|DJC16_HUMAN;tr|Q5TDG9|Q5TDG9_HUMAN;tr|Q5TDH4|Q5TDH4_HUMAN","sp|Q9Y2G8|DJC16_HUMAN;tr|Q5TDG9|Q5TDG9_HUMAN;tr|Q5TDH4|Q5TDH4_HUMAN",4913,"Q9Y2G8","DJC16_HUMAN","DnaJ homolog subfamily C member 16",null,"DNAJC16"]
["18.5051",1,"18.9713","17.8827",{"$nulls":3},"calcium ion regulated exocytosis;endocytosis;endosome to lysosome transport;eosinophil degranulation;ER to Golgi vesicle-mediated transport;Golgi to plasma membrane protein transport;membrane organization;natural killer cell degranulation;neutrophil degranulation;phagocytosis, engulfment;positive regulation of dendrite morphogenesis;positive regulation of histamine secretion by mast cell;post-Golgi vesicle-mediated transport;regulation of protein targeting to vacuolar membrane;SNARE complex assembly;triglyceride transport;vesicle fusion;vesicle fusion with Golgi apparatus;vesicle transport along microtubule;vesicle-mediated transport","SNAP receptor activity;SNARE binding;syntaxin binding","apical part of cell;azurophil granule membrane;cell junction;cell surface;clathrin-coated vesicle membrane;cytoplasm;endoplasmic reticulum membrane;extracellular exosome;integral component of synaptic vesicle membrane;intracellular membrane-bounded organelle;lamellipodium;late endosome membrane;lysosomal membrane;membrane;neuron projection;perinuclear region of cytoplasm;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane;platelet alpha granule;pseudopodium;secretory granule;secretory granule membrane;SNARE complex;trans-Golgi network","SNARE interactions in vesicular transport",null,null,3,3,3,15,15,15,"24.935","0.00025452","6.7485",43896000,5,"0.369734",1,"-8.67446","-0.989169","sp|P51809|VAMP7_HUMAN","sp|P51809|VAMP7_HUMAN",1667,"P51809","VAMP7_HUMAN","Vesicle-associated membrane protein 7","AMP-7","VAMP7"]
[1,"18.9317","18.7421","18.6125",{"$nulls":9},2,2,2,31,31,31,"6.447","0.0015044","3.5782",19801000,4,"0.362772",1,"-8.71143","-0.971596","tr|H7C0D5|H7C0D5_HUMAN;sp|Q9BSR8|YIPF4_HUMAN","tr|H7C0D5|H7C0D5_HUMAN;sp|Q9BSR8|YIPF4_HUMAN",3953,"H7C0D5","H7C0D5_HUMAN",null,null,"YIPF4"]
["17.4755",1,"17.8407","18.1307",{"$nulls":3},"endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ribosome assembly;rRNA processing","ATP binding;GTP binding;GTPase activity;RNA binding;U3 snoRNA binding","90S preribosome;nucleolus;nucleoplasm;nucleus","Ribosome biogenesis in eukaryotes",null,null,4,4,4,"3.4","3.4","3.4","145.81","0.00024558","5.9357",86696000,9,"0.398378",1,"-8.74798","-1.06177","sp|Q14692|BMS1_HUMAN","sp|Q14692|BMS1_HUMAN",2386,"Q14692","BMS1_HUMAN","Ribosome biogenesis protein BMS1 homolog",null,"BMS1"]
["21.0515",1,"21.171","18.4681",{"$nulls":4},"ATP binding;calmodulin binding;calmodulin-dependent protein kinase activity",{"$nulls":4},7,5,5,"20.8",15,15,"60.201",0,"8.6662",147080000,6,"0.322073",1,"-8.7938","-0.869259","tr|A0A0A0MS52|A0A0A0MS52_HUMAN;tr|A0A0A0MT11|A0A0A0MT11_HUMAN;sp|Q13555|KCC2G_HUMAN;tr|Q8WU40|Q8WU40_HUMAN;tr|Q5SWX3|Q5SWX3_HUMAN;tr|H0Y6G2|H0Y6G2_HUMAN","tr|A0A0A0MS52|A0A0A0MS52_HUMAN;tr|A0A0A0MT11|A0A0A0MT11_HUMAN;sp|Q13555|KCC2G_HUMAN;tr|Q8WU40|Q8WU40_HUMAN;tr|Q5SWX3|Q5SWX3_HUMAN;tr|H0Y6G2|H0Y6G2_HUMAN",2277,"A0A0A0MS52","A0A0A0MS52_HUMAN"]
["20.2008",1,"20.2326","18.559",{"$nulls":4},"fatty-acyl-CoA binding",{"$nulls":4},3,3,3,"37.9","37.9","37.9","15.64",0,"8.8336",34554000,7,"0.339369",1,"-8.79536","-0.912683","tr|F8WAW4|F8WAW4_HUMAN;tr|F1LLU7|F1LLU7_HUMAN;tr|C9JB63|C9JB63_HUMAN;tr|A0A0C4DGA2|A0A0C4DGA2_HUMAN;sp|O75521|ECI2_HUMAN;tr|F8W6J1|F8W6J1_HUMAN","tr|F8WAW4|F8WAW4_HUMAN;tr|F1LLU7|F1LLU7_HUMAN;tr|C9JB63|C9JB63_HUMAN;tr|A0A0C4DGA2|A0A0C4DGA2_HUMAN;sp|O75521|ECI2_HUMAN",580,"F8WAW4","F8WAW4_HUMAN",null,null,"ECI2"]
["18.8197",1,"18.4013","19.0263",{"$nulls":4},"catalytic activity",{"$nulls":4},1,1,1,"11.9","11.9","11.9","18.537","0.007986","2.3744",13612000,1,"0.369073",1,"-8.8039","-0.987499","tr|C9JRA9|C9JRA9_HUMAN;tr|C9JCM6|C9JCM6_HUMAN;tr|C9JWU9|C9JWU9_HUMAN;tr|C9JSW2|C9JSW2_HUMAN;tr|C9JW74|C9JW74_HUMAN;sp|Q5EB52|MEST_HUMAN","tr|C9JRA9|C9JRA9_HUMAN;tr|C9JCM6|C9JCM6_HUMAN;tr|C9JWU9|C9JWU9_HUMAN;tr|C9JSW2|C9JSW2_HUMAN;tr|C9JW74|C9JW74_HUMAN;sp|Q5EB52|MEST_HUMAN",2682,"C9JRA9","C9JRA9_HUMAN",null,null,"MEST"]
["18.923",1,"18.9845","18.5524",{"$nulls":3},"histone H3-K4 methylation;histone H3-K4 trimethylation","chromatin binding","chromatin;histone methyltransferase complex;nucleolus;PTW/PP1 phosphatase complex;Set1C/COMPASS complex","mRNA surveillance pathway",null,null,2,2,2,"10.9","10.9","10.9","35.079","0.00046685","4.8935",46669000,6,"0.36708",1,"-8.80692","-0.982467","sp|Q6UXN9|WDR82_HUMAN","sp|Q6UXN9|WDR82_HUMAN",2913,"Q6UXN9","WDR82_HUMAN","WD repeat-containing protein 82",null,"WDR82"]
[1,"19.3144","18.1143","19.9209",{"$nulls":3},"detection of light stimulus involved in visual perception;regulation of intracellular transport",null,"apical part of cell;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;nucleus;photoreceptor inner segment;rod spherule",{"$nulls":3},2,2,2,"12.5","12.5","12.5","20.733","0.00046674","4.8878",32411000,5,"0.359327",1,"-8.86037","-0.96291","sp|Q96HR9|REEP6_HUMAN;tr|A8MXN1|A8MXN1_HUMAN;tr|A8MWX0|A8MWX0_HUMAN","sp|Q96HR9|REEP6_HUMAN;tr|A8MXN1|A8MXN1_HUMAN;tr|A8MWX0|A8MWX0_HUMAN",3722,"Q96HR9","REEP6_HUMAN","Receptor expression-enhancing protein 6",null,"REEP6"]
[1,"20.4181","18.1868","21.0354",{"$nulls":3},"regulation of ATPase activity;vacuolar proton-transporting V-type ATPase complex assembly",null,"endoplasmic reticulum membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;ER to Golgi transport vesicle membrane;integral component of membrane;lysosome",{"$nulls":3},2,2,2,"21.8","21.8","21.8","11.354","0.0013123","3.8488",32242000,4,"0.337176",1,"-8.90207","-0.907173","sp|Q3ZAQ7|VMA21_HUMAN","sp|Q3ZAQ7|VMA21_HUMAN",2620,"Q3ZAQ7","VMA21_HUMAN","Vacuolar ATPase assembly integral membrane protein VMA21 {ECO:0000255|HAMAP-Rule:MF_03058}",null,"VMA21"]
["18.1419",1,"19.3601","17.6122",{"$nulls":3},"ceramide metabolic process;L-fucose catabolic process;protein glycosylation","3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity;alpha-(1->3)-fucosyltransferase activity;fucosyltransferase activity","extracellular exosome;Golgi apparatus;Golgi cisterna membrane;Golgi membrane;integral component of membrane","Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways",null,null,3,3,3,"11.4","11.4","11.4","41.859","0.00026688","7.7401",79350000,7,"0.387763",1,"-8.91524","-1.03481","sp|P51993|FUT6_HUMAN;sp|P21217|FUT3_HUMAN;tr|K7ENC0|K7ENC0_HUMAN;sp|Q11128|FUT5_HUMAN","sp|P51993|FUT6_HUMAN;sp|P21217|FUT3_HUMAN;tr|K7ENC0|K7ENC0_HUMAN;sp|Q11128|FUT5_HUMAN",1158,"P51993","FUT6_HUMAN","Alpha-(1,3)-fucosyltransferase 6",null,"FUT6"]
[1,"17.1325","18.3035","17.6792",{"$nulls":3},"coenzyme A biosynthetic process","ATP binding;dephospho-CoA kinase activity",{"$nulls":4},7,7,7,44,44,44,"24.177",0,"21.456",149000000,22,"0.415577",1,"-8.92512","-1.10565","tr|K7ESP4|K7ESP4_HUMAN;sp|Q8WVC6|DCAKD_HUMAN","tr|K7ESP4|K7ESP4_HUMAN;sp|Q8WVC6|DCAKD_HUMAN",3437,"K7ESP4","K7ESP4_HUMAN",null,null,"DCAKD"]
["18.1549",1,"18.5106","18.5115",{"$nulls":3},"mitochondrial transport","transmembrane transporter activity","integral component of membrane;mitochondrial inner membrane",{"$nulls":3},3,3,3,"10.4","10.4","10.4","38.124",0,"8.8954",196870000,16,"0.39041",1,"-8.93362","-1.04152","sp|Q8TBP6|S2540_HUMAN","sp|Q8TBP6|S2540_HUMAN",3369,"Q8TBP6","S2540_HUMAN","Solute carrier family 25 member 40",null,"SLC25A40"]
[1,"19.028","19.2332","18.7141",{"$nulls":9},6,1,1,"32.7","7.2","7.2","32.136",0,"9.6981",48017000,0,"0.371473",1,"-8.95967","-0.993563","tr|C9JA93|C9JA93_HUMAN","tr|C9JA93|C9JA93_HUMAN",5185,"C9JA93","C9JA93_HUMAN",null,null,"TBC1D15"]
["19.7061",1,"20.1906","18.4621",{"$nulls":3},"cell growth;rRNA modification;rRNA processing;snoRNA localization","ATPase binding;RNA binding;snoRNA binding;TFIID-class transcription factor binding","box C/D snoRNP complex;Cajal body;cytosol;fibrillar center;membrane;nucleolus;nucleoplasm;nucleus;pre-snoRNP complex;small nucleolar ribonucleoprotein complex;small-subunit processome","Ribosome biogenesis in eukaryotes",null,null,20,20,20,"44.6","44.6","44.6","59.578",0,"127.32",1913900000,182,"0.35632",1,"-8.97332","-0.955332","sp|Q9Y2X3|NOP58_HUMAN;tr|H7BZ72|H7BZ72_HUMAN;tr|F8WED0|F8WED0_HUMAN","sp|Q9Y2X3|NOP58_HUMAN",4947,"Q9Y2X3","NOP58_HUMAN","Nucleolar protein 58",null,"NOP58"]
["20.5333",1,"20.8082","18.7064",{"$nulls":3},"cell proliferation;multicellular organism development;neutrophil degranulation;regulation of growth;regulation of transcription from RNA polymerase II promoter","cofactor binding;transcription corepressor activity;transcription factor binding","azurophil granule lumen;extracellular exosome;extracellular region;extracellular space;transcription factor complex",{"$nulls":3},1,1,1,"9.5","9.5","9.5","24.074","0.00026838","7.8984",50922000,1,"0.340398",1,"-8.99069","-0.915269","sp|O75629|CREG1_HUMAN","sp|O75629|CREG1_HUMAN",595,"O75629","CREG1_HUMAN","Protein CREG1",null,"CREG1"]
["19.4248",1,"18.756","19.6542",{"$nulls":3},"ergosterol biosynthetic process","protein binding, bridging","endoplasmic reticulum membrane;integral component of membrane;transport vesicle",{"$nulls":3},2,2,2,"13.6","13.6","13.6","15.864","0.0013046","3.77",50347000,4,"0.364118",1,"-8.9927","-0.974993","sp|Q9UKR5|ERG28_HUMAN","sp|Q9UKR5|ERG28_HUMAN",4791,"Q9UKR5","ERG28_HUMAN","Probable ergosterol biosynthetic protein 28",null,"ERG28"]
["17.2267",1,"17.8857","18.3442",{"$nulls":3},"bicarbonate transport;morphogenesis of an epithelium;one-carbon metabolic process;regulation of transcription from RNA polymerase II promoter in response to hypoxia;response to drug;response to testosterone;secretion","carbonate dehydratase activity;zinc ion binding","basolateral plasma membrane;integral component of membrane;microvillus membrane;nucleolus;plasma membrane","Metabolic pathways;Nitrogen metabolism",null,null,2,2,2,"6.5","6.5","6.5","49.697","0.00025582","6.8882",98682000,9,"0.416903",1,"-9.00161","-1.10904","sp|Q16790|CAH9_HUMAN","sp|Q16790|CAH9_HUMAN",2574,"Q16790","CAH9_HUMAN","Carbonic anhydrase 9",null,"CA9"]
["16.5587",1,"18.99","16.6051",{"$nulls":3},"myelination;negative regulation of transcription, DNA-templated;positive regulation of transcription from RNA polymerase II promoter","DNA binding;sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding;zinc ion binding","nucleus",{"$nulls":3},9,9,9,38,38,38,"42.155",0,"77.514",643110000,49,"0.43126",1,"-9.01823","-1.14587","sp|P17028|ZNF24_HUMAN;tr|K7EQP8|K7EQP8_HUMAN;tr|K7EPZ8|K7EPZ8_HUMAN;tr|K7EPL1|K7EPL1_HUMAN","sp|P17028|ZNF24_HUMAN",1090,"P17028","ZNF24_HUMAN","Zinc finger protein 24",null,"ZNF24"]
["18.9142",1,"18.9877","18.9816",{"$nulls":3},"mitochondrial respiratory chain complex I assembly",null,"integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},2,2,2,"13.9","13.9","13.9","25.943","0.00025654","6.941",106190000,16,"0.37713",1,"-9.02756","-1.00787","sp|Q8IUX1|T126B_HUMAN;tr|H0YEG5|H0YEG5_HUMAN;tr|E9PKZ9|E9PKZ9_HUMAN;tr|E9PJQ6|E9PJQ6_HUMAN;tr|E9PKZ7|E9PKZ7_HUMAN;tr|H0YD74|H0YD74_HUMAN","sp|Q8IUX1|T126B_HUMAN;tr|H0YEG5|H0YEG5_HUMAN;tr|E9PKZ9|E9PKZ9_HUMAN;tr|E9PJQ6|E9PJQ6_HUMAN;tr|E9PKZ7|E9PKZ7_HUMAN;tr|H0YD74|H0YD74_HUMAN",3107,"Q8IUX1","T126B_HUMAN","Complex I assembly factor TMEM126B, mitochondrial",null,"TMEM126B"]
["16.9395",1,"17.5709","18.4486",{"$nulls":3},"cellular response to interferon-gamma;phagosome acidification;phagosome-lysosome fusion;protein transport;regulation of endocytosis","GTP binding;GTPase activity","early endosome;Golgi apparatus;intracellular membrane-bounded organelle;phagocytic vesicle;phagocytic vesicle membrane;plasma membrane",{"$nulls":3},2,2,2,"11.1","11.1","11.1","26.277","0.00024618","6.0208",74072000,11,"0.426084",1,"-9.04001","-1.13257","sp|Q9NX57|RAB20_HUMAN","sp|Q9NX57|RAB20_HUMAN",4534,"Q9NX57","RAB20_HUMAN","Ras-related protein Rab-20",null,"RAB20"]
["20.1972",1,"20.1154","19.2144",{"$nulls":3},"apoptotic process;autophagy;endoplasmic reticulum membrane fusion;endoplasmic reticulum organization;execution phase of apoptosis;negative regulation of apoptotic process;retrograde vesicle-mediated transport, Golgi to ER","SNAP receptor activity","cytoplasm;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;intracellular membrane-bounded organelle;mitochondrion;nuclear envelope;SNARE complex","SNARE interactions in vesicular transport",null,null,5,5,5,"25.9","25.9","25.9","26.132","0.00025183","6.5036",115280000,7,"0.351623",1,"-9.0663","-0.943504","sp|Q12981|SEC20_HUMAN","sp|Q12981|SEC20_HUMAN",2190,"Q12981","SEC20_HUMAN","Vesicle transport protein SEC20",null,"BNIP1"]
["20.2207",1,"19.9324","19.4529",{"$nulls":3},"cell division;centriole replication;ciliary basal body-plasma membrane docking;G2/M transition of mitotic cell cycle;global genome nucleotide-excision repair;mitotic cell cycle;nucleotide-excision repair;nucleotide-excision repair, DNA damage recognition;nucleotide-excision repair, DNA duplex unwinding;nucleotide-excision repair, preincision complex assembly;regulation of cytokinesis;regulation of G2/M transition of mitotic cell cycle;spermatogenesis","calcium ion binding;G-protein beta/gamma-subunit complex binding;heterotrimeric G-protein binding;microtubule binding","centriole;centrosome;ciliary basal body;cytosol;intracellular;nucleoplasm;photoreceptor connecting cilium;XPC complex","Nucleotide excision repair",null,null,6,6,6,"48.3","48.3","48.3","19.738",0,"201.26",591810000,44,"0.352124",1,"-9.08234","-0.944765","sp|P41208|CETN2_HUMAN;sp|Q12798|CETN1_HUMAN","sp|P41208|CETN2_HUMAN",1450,"P41208","CETN2_HUMAN","Centrin-2",null,"CETN2"]
["18.5837",1,"18.8584","18.9545",{"$nulls":3},"positive regulation of translation","RNA binding","cytoplasmic stress granule;cytosol;membrane;nucleolus;polysomal ribosome",{"$nulls":3},7,7,7,"14.8","14.8","14.8","80.551",0,"34.235",149750000,26,"0.388508",1,"-9.11459","-1.0367","sp|Q92615|LAR4B_HUMAN;tr|H0Y641|H0Y641_HUMAN;tr|H0Y4V9|H0Y4V9_HUMAN;tr|X6RCG6|X6RCG6_HUMAN;tr|B5MCU2|B5MCU2_HUMAN;tr|V9GYI5|V9GYI5_HUMAN","sp|Q92615|LAR4B_HUMAN",3508,"Q92615","LAR4B_HUMAN","La-related protein 4B",null,"LARP4B"]
["18.5666",1,"19.077","18.7632",{"$nulls":3},"regulation of small GTPase mediated signal transduction;signal transduction","GTPase activator activity;SH3 domain binding","bicellular tight junction;cytosol;nucleus;plasma membrane","Tight junction",null,null,7,7,7,"13.5","13.5","13.5","95.436",0,"24.524",88959000,16,"0.389844",1,"-9.13683","-1.04009","sp|Q68EM7|RHG17_HUMAN;tr|C9IZD3|C9IZD3_HUMAN;tr|I3L4P0|I3L4P0_HUMAN;tr|I3L1S9|I3L1S9_HUMAN;tr|I3L4P6|I3L4P6_HUMAN;tr|I3L3P1|I3L3P1_HUMAN;tr|I3L4Y5|I3L4Y5_HUMAN;tr|J3KRS3|J3KRS3_HUMAN;tr|I3L460|I3L460_HUMAN;tr|F5H6L3|F5H6L3_HUMAN;tr|E7ERK8|E7ERK8_HUMAN;sp|Q17R89|RHG44_HUMAN","sp|Q68EM7|RHG17_HUMAN;tr|C9IZD3|C9IZD3_HUMAN",2798,"Q68EM7","RHG17_HUMAN","Rho GTPase-activating protein 17",null,"ARHGAP17"]
["15.4773",1,"15.7863","18.988",{"$nulls":3},"cell adhesion","cadherin binding","cytosol;focal adhesion;plasma membrane",{"$nulls":3},16,16,14,24,24,"21.8","114.02",0,"85.255",486000000,66,"0.465307",1,"-9.14851","-1.23402","sp|Q86W92|LIPB1_HUMAN;tr|F5GZP6|F5GZP6_HUMAN;tr|H0YFE4|H0YFE4_HUMAN;tr|A0A0A0MTP2|A0A0A0MTP2_HUMAN;tr|H0YGH8|H0YGH8_HUMAN;tr|F5H6Q7|F5H6Q7_HUMAN;tr|F5H0E0|F5H0E0_HUMAN;tr|F5H495|F5H495_HUMAN","sp|Q86W92|LIPB1_HUMAN;tr|F5GZP6|F5GZP6_HUMAN",3068,"Q86W92","LIPB1_HUMAN","Liprin-beta-1",null,"PPFIBP1"]
["19.5337",1,"19.5309","19.3138",{"$nulls":3},"adaptive immune response;complement activation, classical pathway;innate immune response;interleukin-10 production;negative regulation of gene expression;positive regulation of gene expression;positive regulation of interleukin-10 production;positive regulation of memory T cell differentiation;positive regulation of regulatory T cell differentiation;positive regulation of T cell proliferation;positive regulation of transforming growth factor beta production;regulation of complement activation;regulation of Notch signaling pathway;sequestering of extracellular ligand from receptor;single fertilization;T cell mediated immunity","cadherin binding;receptor activity;virus receptor activity","cell surface;extracellular exosome;focal adhesion;inner acrosomal membrane;integral component of plasma membrane;plasma membrane","Complement and coagulation cascades;Measles",null,null,2,2,2,"3.1","3.1","3.1","43.747","0.0023197","3.3554",115220000,7,"0.369238",1,"-9.15553","-0.987918","sp|P15529|MCP_HUMAN","sp|P15529|MCP_HUMAN",1062,"P15529","MCP_HUMAN","Membrane cofactor protein",null,"CD46"]
["19.3483",1,"20.2446","18.4301",{"$nulls":3},"response to ionizing radiation","beta-catenin binding",{"$nulls":4},3,3,1,"27.9","27.9","5.8","21.494","0.00025602","6.8968",51090000,7,"0.371628",1,"-9.16318","-0.993954","sp|Q8WZA0|LZIC_HUMAN","sp|Q8WZA0|LZIC_HUMAN",3475,"Q8WZA0","LZIC_HUMAN","Protein LZIC",null,"LZIC"]
["18.7099",1,"19.0806","18.9823",{"$nulls":5},"integral component of membrane",{"$nulls":3},7,1,1,"36.6","4.6","4.6","28.549","0.00023557","5.1203",40977000,5,"0.38835",1,"-9.1765","-1.0363","tr|E9PIE4|E9PIE4_HUMAN","tr|E9PIE4|E9PIE4_HUMAN",5214,"E9PIE4","E9PIE4_HUMAN",null,null,"MTCH2"]
[1,"18.5323","18.4737","19.4121",{"$nulls":3},"actin cytoskeleton organization","actin binding",{"$nulls":4},9,1,1,"46.2","8.4","8.4","28.634","0.00026434","7.5172",32360000,4,"0.391914",1,"-9.17675","-1.04534","tr|Q5T0R9|Q5T0R9_HUMAN;tr|Q5T0S3|Q5T0S3_HUMAN;tr|Q5T0R8|Q5T0R8_HUMAN","tr|Q5T0R9|Q5T0R9_HUMAN",5294,"Q5T0R9","Q5T0R9_HUMAN",null,null,"CAP1"]
["17.597",1,"17.2048","19.7758",{"$nulls":3},"glutaminyl-tRNAGln biosynthesis via transamidation;mitochondrial translation","ATP binding;glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity","glutamyl-tRNA(Gln) amidotransferase complex;mitochondrion",{"$nulls":3},6,6,6,"15.1","15.1","15.1","57.653",0,"28.271",91039000,12,"0.411248",1,"-9.19175","-1.09458","tr|D6REA0|D6REA0_HUMAN;sp|O75879|GATB_HUMAN;tr|D6RDU9|D6RDU9_HUMAN","tr|D6REA0|D6REA0_HUMAN;sp|O75879|GATB_HUMAN;tr|D6RDU9|D6RDU9_HUMAN",620,"D6REA0","D6REA0_HUMAN","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial {ECO:0000256|HAMAP-Rule:MF_03147}","lu-AdT subunit B {ECO:0000256|HAMAP-Rule:MF_03147}"]
["21.5811",1,"21.5588","19.4205",{"$nulls":3},"mitochondrial translation;mitochondrial translational elongation;mitochondrial translational termination","structural constituent of ribosome","mitochondrial inner membrane;mitochondrial ribosome",{"$nulls":3},1,1,1,"12.7","12.7","12.7","12.266","0.0037283","3.1087",37561000,5,"0.329999",1,"-9.19909","-0.88915","sp|Q9BQC6|RT63_HUMAN","sp|Q9BQC6|RT63_HUMAN",3917,"Q9BQC6","RT63_HUMAN","Ribosomal protein 63, mitochondrial","MRP63","MRPL57"]
["18.671",1,"18.768","19.4032",{"$nulls":5},"extracellular region",{"$nulls":3},4,4,4,"23.1","23.1","23.1","23.865",0,"9.6252",94443000,13,"0.39227",1,"-9.25012","-1.04625","sp|Q8WUY1|THEM6_HUMAN;tr|H0YAR9|H0YAR9_HUMAN","sp|Q8WUY1|THEM6_HUMAN",3430,"Q8WUY1","THEM6_HUMAN","Protein THEM6",null,"THEM6"]
["17.8088",1,"18.3051","19.0118",{"$nulls":3},"COPII vesicle coating;G1/S transition of mitotic cell cycle;innate immune response;protein dephosphorylation","metal ion binding;protein serine/threonine phosphatase activity","cytosol;Golgi membrane;mitochondrion",{"$nulls":3},4,4,4,"15.7","15.7","15.7","35.144",0,"10.074",67454000,9,"0.413417",1,"-9.25405","-1.10013","sp|O00743|PPP6_HUMAN;tr|Q5T1S7|Q5T1S7_HUMAN","sp|O00743|PPP6_HUMAN",251,"O00743","PPP6_HUMAN","Serine/threonine-protein phosphatase 6 catalytic subunit","P6C","PPP6C"]
["19.0612",1,"19.2491","19.3505",{"$nulls":5},"nucleolus;nucleus",{"$nulls":3},1,1,1,"7.9","7.9","7.9","33.441",0,"9.8493",57353000,4,"0.384451",1,"-9.26922","-1.02641","tr|K7EN33|K7EN33_HUMAN;tr|A0A0A0MRH0|A0A0A0MRH0_HUMAN;sp|Q9NVX2|NLE1_HUMAN","tr|K7EN33|K7EN33_HUMAN;tr|A0A0A0MRH0|A0A0A0MRH0_HUMAN;sp|Q9NVX2|NLE1_HUMAN",4506,"K7EN33","K7EN33_HUMAN",null,null,"NLE1"]
["18.7041",1,"19.1068","19.2028",{"$nulls":3},"Cajal body organization",{"$nulls":5},1,1,1,"5.8","5.8","5.8","30.813","0.00024752","6.1734",52435000,8,"0.3941",1,"-9.30273","-1.0509","tr|G3V179|G3V179_HUMAN;tr|E9PMJ2|E9PMJ2_HUMAN;tr|J3KP39|J3KP39_HUMAN;sp|Q9BPY3|F118B_HUMAN","tr|G3V179|G3V179_HUMAN;tr|E9PMJ2|E9PMJ2_HUMAN;tr|J3KP39|J3KP39_HUMAN;sp|Q9BPY3|F118B_HUMAN",3905,"G3V179","G3V179_HUMAN",null,null,"FAM118B"]
["18.9957",1,"19.5288","19.0762",{"$nulls":5},"nucleus",{"$nulls":3},1,1,1,"5.8","5.8","5.8","25.977",0,"11.837",116820000,17,"0.387357",1,"-9.30468","-1.03378","sp|Q8IYL3|CA174_HUMAN","sp|Q8IYL3|CA174_HUMAN",3168,"Q8IYL3","CA174_HUMAN","UPF0688 protein C1orf174",null,"C1orf174"]
["18.7894",1,"18.4661","19.9332",{"$nulls":5},"centrosome;cytosol;gamma-tubulin ring complex;microtubule organizing center;nucleoplasm;spindle",{"$nulls":3},3,3,3,"35.4","35.4","35.4","16.22","0.0002594","7.1833",45432000,5,"0.390826",1,"-9.30493","-1.04258","sp|Q6P582|MZT2A_HUMAN;sp|Q6NZ67|MZT2B_HUMAN;tr|B8ZZ87|B8ZZ87_HUMAN;tr|H7BZ50|H7BZ50_HUMAN;tr|H7C173|H7C173_HUMAN;tr|H7C202|H7C202_HUMAN","sp|Q6P582|MZT2A_HUMAN;sp|Q6NZ67|MZT2B_HUMAN;tr|B8ZZ87|B8ZZ87_HUMAN;tr|H7BZ50|H7BZ50_HUMAN;tr|H7C173|H7C173_HUMAN;tr|H7C202|H7C202_HUMAN",2843,"Q6P582","MZT2A_HUMAN","Mitotic-spindle organizing protein 2A",null,"MZT2A"]
[1,"20.4661","20.0682","20.0927",{"$nulls":9},3,3,3,"54.8","54.8","54.8","6.8649","0.00025113","6.4508",57329000,5,"0.358321",1,"-9.34739","-0.960374","tr|E9PN66|E9PN66_HUMAN;tr|E9PKN9|E9PKN9_HUMAN;tr|E9PS55|E9PS55_HUMAN;tr|E9PMW4|E9PMW4_HUMAN;tr|E9PQ46|E9PQ46_HUMAN;tr|E9PIN5|E9PIN5_HUMAN;tr|E9PIK4|E9PIK4_HUMAN;tr|U3KQ32|U3KQ32_HUMAN;tr|E9PKZ4|E9PKZ4_HUMAN;sp|O14683|P5I11_HUMAN;tr|E9PPM1|E9PPM1_HUMAN;tr|E9PNB3|E9PNB3_HUMAN;tr|E9PMY0|E9PMY0_HUMAN","tr|E9PN66|E9PN66_HUMAN;tr|E9PKN9|E9PKN9_HUMAN;tr|E9PS55|E9PS55_HUMAN;tr|E9PMW4|E9PMW4_HUMAN;tr|E9PQ46|E9PQ46_HUMAN;tr|E9PIN5|E9PIN5_HUMAN;tr|E9PIK4|E9PIK4_HUMAN;tr|U3KQ32|U3KQ32_HUMAN;tr|E9PKZ4|E9PKZ4_HUMAN;sp|O14683|P5I11_HUMAN;tr|E9PPM1|E9PPM1_HUMAN;tr|E9PNB3|E9PNB3_HUMAN;tr|E9PMY0|E9PMY0_HUMAN",274,"E9PN66","E9PN66_HUMAN",null,null,"TP53I11"]
["19.0727",1,"19.5158","19.3091",{"$nulls":3},"activation of protein kinase activity;apoptotic process;cell growth involved in cardiac muscle cell development;cellular response to mechanical stimulus;cellular response to sorbitol;Fc-epsilon receptor signaling pathway;JNK cascade;negative regulation of motor neuron apoptotic process;positive regulation of DNA replication;positive regulation of neuron apoptotic process;positive regulation of nitric-oxide synthase biosynthetic process;positive regulation of smooth muscle cell apoptotic process;proteolysis in other organism;regulation of apoptotic process;regulation of mitotic cell cycle;response to wounding;signal transduction;signal transduction by protein phosphorylation;stress-activated protein kinase signaling cascade","ATP binding;JUN kinase kinase activity;mitogen-activated protein kinase kinase kinase binding;protein kinase activity;protein serine/threonine kinase activity;protein tyrosine kinase activity","axon;cytoplasm;cytosol;dendrite cytoplasm;nucleus;perikaryon","Chagas disease (American trypanosomiasis);Epithelial cell signaling in Helicobacter pylori infection;Epstein-Barr virus infection;ErbB signaling pathway;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;GnRH signaling pathway;Hepatitis B;Human T-cell leukemia virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;MAPK signaling pathway;Relaxin signaling pathway;TNF signaling pathway;Toll-like receptor signaling pathway;Yersinia infection",null,null,7,6,6,"20.6","18.8","18.8","44.287",0,"34.35",110750000,10,"0.388836",1,"-9.37609","-1.03753","sp|P45985|MP2K4_HUMAN;tr|R4GN37|R4GN37_HUMAN","sp|P45985|MP2K4_HUMAN",1500,"P45985","MP2K4_HUMAN","Dual specificity mitogen-activated protein kinase kinase 4","AP kinase kinase 4;APKK 4","MAP2K4"]
["18.3617",1,"18.5171","19.6046",{"$nulls":9},3,3,3,"31.1","31.1","31.1","15.131","0.00026157","7.3059",44835000,8,"0.404914",1,"-9.37996","-1.07842","tr|F8WDS8|F8WDS8_HUMAN;tr|C9J0U9|C9J0U9_HUMAN;tr|D3YTH5|D3YTH5_HUMAN;sp|Q53HC9|TSSC1_HUMAN;tr|A8MUM1|A8MUM1_HUMAN;tr|F8WDX0|F8WDX0_HUMAN;tr|F8WB12|F8WB12_HUMAN","tr|F8WDS8|F8WDS8_HUMAN;tr|C9J0U9|C9J0U9_HUMAN;tr|D3YTH5|D3YTH5_HUMAN;sp|Q53HC9|TSSC1_HUMAN;tr|A8MUM1|A8MUM1_HUMAN;tr|F8WDX0|F8WDX0_HUMAN;tr|F8WB12|F8WB12_HUMAN",2659,"F8WDS8","F8WDS8_HUMAN",null,null,"EIPR1"]
["20.1672",1,"20.633","19.4031",{"$nulls":3},"activation of MAPKK activity;cellular response to cAMP;cellular response to drug;cellular response to glucose stimulus;cellular response to nerve growth factor stimulus;establishment of endothelial barrier;liver regeneration;negative regulation of collagen biosynthetic process;negative regulation of synaptic vesicle exocytosis;nerve growth factor signaling pathway;neutrophil degranulation;positive regulation of ERK1 and ERK2 cascade;positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;positive regulation of glucose import;positive regulation of GTPase activity;positive regulation of neuron projection development;positive regulation of protein kinase activity;positive regulation of vasculogenesis;protein transport;Rap protein signal transduction;regulation of cell junction assembly;regulation of insulin secretion;response to antineoplastic agent;signal transduction","GTP binding;GTPase activity;protein complex binding;protein transporter activity;Rap guanyl-nucleotide exchange factor activity","cell junction;cytoplasm;cytosol;early endosome;extracellular exosome;guanyl-nucleotide exchange factor complex;late endosome;myelin sheath;neuron projection;perinuclear region of cytoplasm;phagocytic vesicle;plasma membrane;specific granule membrane","cAMP signaling pathway;Chemokine signaling pathway;Cushing syndrome;Focal adhesion;Leukocyte transendothelial migration;Long-term potentiation;MAPK signaling pathway;Neurotrophin signaling pathway;Pancreatic secretion;Platelet activation;Rap1 signaling pathway;Ras signaling pathway;Renal cell carcinoma;Tight junction",null,null,7,1,1,"39.7","7.1","7.1","20.987","0.00023844","5.3838",59708000,4,"0.36706",1,"-9.43443","-0.982416","sp|P62834|RAP1A_HUMAN;tr|A0A075B6Q0|A0A075B6Q0_HUMAN;tr|F5H4H0|F5H4H0_HUMAN;tr|F5GYH7|F5GYH7_HUMAN;tr|F8WBC0|F8WBC0_HUMAN","sp|P62834|RAP1A_HUMAN;tr|A0A075B6Q0|A0A075B6Q0_HUMAN;tr|F5H4H0|F5H4H0_HUMAN;tr|F5GYH7|F5GYH7_HUMAN",1911,"P62834","RAP1A_HUMAN","Ras-related protein Rap-1A",null,"RAP1A"]
["17.9662",1,"18.9224","18.9587",{"$nulls":3},"calcium ion regulated exocytosis;cellular response to acidic pH;cytoplasmic microtubule organization;hyaluronan catabolic process;membrane docking;membrane fusion;membrane organization;microtubule bundle formation;negative regulation of calcineurin-NFAT signaling cascade;negative regulation of NF-kappaB transcription factor activity;negative regulation of phosphatase activity;negative regulation of protein autophosphorylation;negative regulation of protein import into nucleus;negative regulation of protein kinase activity;negative regulation of protein phosphorylation;negative regulation of protein ubiquitination;positive regulation of protein glycosylation;positive regulation of protein targeting to membrane;positive regulation of protein transport;positive regulation of sodium:proton antiporter activity;potassium ion transport;protein export from nucleus;protein oligomerization;protein stabilization;regulation of intracellular pH;regulation of neuron death;small GTPase mediated signal transduction","calcium ion binding;calcium-dependent protein binding;kinase binding;microtubule binding;potassium channel regulator activity;protein kinase inhibitor activity;transporter activity","cytoplasm;cytosol;endoplasmic reticulum;endoplasmic reticulum-Golgi intermediate compartment;extracellular exosome;focal adhesion;Golgi membrane;microtubule cytoskeleton;nucleus;plasma membrane;transport vesicle",{"$nulls":3},2,2,2,"13.8","13.8","13.8","22.456","0.00024378","5.7892",49682000,6,"0.419171",1,"-9.45741","-1.11485","sp|Q99653|CHP1_HUMAN;tr|H0YLY7|H0YLY7_HUMAN;tr|H0YKE7|H0YKE7_HUMAN;tr|F5GX29|F5GX29_HUMAN;tr|H0YNG9|H0YNG9_HUMAN","sp|Q99653|CHP1_HUMAN;tr|H0YLY7|H0YLY7_HUMAN;tr|H0YKE7|H0YKE7_HUMAN;tr|F5GX29|F5GX29_HUMAN;tr|H0YNG9|H0YNG9_HUMAN",3872,"Q99653","CHP1_HUMAN","Calcineurin B homologous protein 1",null,"CHP1"]
["17.9141",1,"19.1184","18.8619",{"$nulls":9},2,2,2,"9.9","9.9","9.9","39.241",0,"14.075",51353000,9,"0.423953",1,"-9.53308","-1.12711","tr|B2WTI3|B2WTI3_HUMAN;tr|B2WTI4|B2WTI4_HUMAN;tr|K7EJU9|K7EJU9_HUMAN;sp|Q6NYC1|JMJD6_HUMAN","tr|B2WTI3|B2WTI3_HUMAN;tr|B2WTI4|B2WTI4_HUMAN;tr|K7EJU9|K7EJU9_HUMAN;sp|Q6NYC1|JMJD6_HUMAN",2842,"B2WTI3","B2WTI3_HUMAN"]
["17.9811",1,"19.1301","18.9415",{"$nulls":3},"DNA biosynthetic process;DNA metabolic process;nucleobase-containing compound metabolic process;protein homotetramerization;pyrimidine nucleoside salvage;thymidine metabolic process","ATP binding;identical protein binding;nucleoside kinase activity;thymidine kinase activity;zinc ion binding","cytosol","Drug metabolism - other enzymes;Metabolic pathways;Pyrimidine metabolism",null,null,2,2,2,"9.8","9.8","9.8","25.468","0.00069461","4.7527",47822000,2,"0.422799",1,"-9.54521","-1.12414","sp|P04183|KITH_HUMAN;tr|K7ES52|K7ES52_HUMAN;tr|K7ERJ1|K7ERJ1_HUMAN;tr|K7ERV3|K7ERV3_HUMAN","sp|P04183|KITH_HUMAN;tr|K7ES52|K7ES52_HUMAN;tr|K7ERJ1|K7ERJ1_HUMAN;tr|K7ERV3|K7ERV3_HUMAN",838,"P04183","KITH_HUMAN","Thymidine kinase, cytosolic",null,"TK1"]
["21.1839",1,"21.1499","20.1763",{"$nulls":3},"chromosome segregation","metal ion binding","cytosol;nucleoplasm;nucleus",{"$nulls":3},4,4,4,"28.1","28.1","28.1","18.355",0,"14.821",100350000,3,"0.353127",1,"-9.57113","-0.94729","sp|Q9H5X1|FA96A_HUMAN;tr|H0YKV4|H0YKV4_HUMAN;tr|H0YLH6|H0YLH6_HUMAN","sp|Q9H5X1|FA96A_HUMAN;tr|H0YKV4|H0YKV4_HUMAN;tr|H0YLH6|H0YLH6_HUMAN",4224,"Q9H5X1","FA96A_HUMAN","MIP18 family protein FAM96A",null,"FAM96A"]
["19.9797",1,"20.4027","19.7234",{"$nulls":3},"intra-Golgi vesicle-mediated transport;mitotic cell cycle;regulation of centrosome duplication;response to drug;retrograde transport, endosome to Golgi;retrograde vesicle-mediated transport, Golgi to ER;small GTPase mediated signal transduction","GTP binding;GTPase activity","centrosome;cytosol;Golgi apparatus;intracellular;nucleus",{"$nulls":3},2,1,1,"12.2","8.7","8.7","28.355",0,"17.457",77778000,1,"0.377238",1,"-9.57322","-1.00814","sp|Q9H0N0|RAB6C_HUMAN","sp|Q9H0N0|RAB6C_HUMAN",4138,"Q9H0N0","RAB6C_HUMAN","Ras-related protein Rab-6C",null,"RAB6C"]
["16.9001",1,"17.9618","19.1749",{"$nulls":3},"cellular response to stimulus;hippocampus development;negative regulation of translational initiation in response to stress;oligodendrocyte development;response to glucose;response to heat;response to peptide hormone;translational initiation","guanyl-nucleotide exchange factor activity;nucleotidyltransferase activity;translation initiation factor activity","cytoplasm;cytosol;eukaryotic translation initiation factor 2B complex","Herpes simplex virus 1 infection;RNA transport",null,null,12,12,12,"31.4","31.4","31.4","50.24",0,"32.534",289620000,41,"0.454666",1,"-9.61833","-1.20634","sp|Q9NR50|EI2BG_HUMAN;tr|A0A0D9SEN0|A0A0D9SEN0_HUMAN;tr|H0Y580|H0Y580_HUMAN","sp|Q9NR50|EI2BG_HUMAN",4410,"Q9NR50","EI2BG_HUMAN","Translation initiation factor eIF-2B subunit gamma",null,"EIF2B3"]
["18.1056",1,"18.9753","19.5069",{"$nulls":3},"acetate biosynthetic process;acetyl-CoA biosynthetic process;acetyl-CoA biosynthetic process from acetate;ethanol oxidation;propionate biosynthetic process","acetate-CoA ligase activity;AMP binding;ATP binding","mitochondrial matrix","Carbon metabolism;Glycolysis / Gluconeogenesis;Glyoxylate and dicarboxylate metabolism;Metabolic pathways;Propanoate metabolism;Pyruvate metabolism",null,null,6,6,6,"17.1","17.1","17.1","74.856",0,"25.099",144180000,16,"0.425942",1,"-9.68825","-1.13221","sp|Q9NUB1|ACS2L_HUMAN","sp|Q9NUB1|ACS2L_HUMAN",4459,"Q9NUB1","ACS2L_HUMAN","Acetyl-coenzyme A synthetase 2-like, mitochondrial",null,"ACSS1"]
["18.587",1,"22.0959","16.8894",{"$nulls":3},"exocytosis;Golgi to plasma membrane transport;post-Golgi vesicle-mediated transport;protein transport;vesicle docking","protein N-terminus binding;Ral GTPase binding","cytoplasm;cytosol;exocyst;midbody",{"$nulls":3},17,17,17,"30.2","30.2","30.2","81.852",0,"139.25",929130000,91,"0.396747",1,"-9.69919","-1.05763","sp|O00471|EXOC5_HUMAN;tr|A0A0A0MSI8|A0A0A0MSI8_HUMAN;tr|F8W9B8|F8W9B8_HUMAN;tr|G3V377|G3V377_HUMAN","sp|O00471|EXOC5_HUMAN;tr|A0A0A0MSI8|A0A0A0MSI8_HUMAN;tr|F8W9B8|F8W9B8_HUMAN",232,"O00471","EXOC5_HUMAN","Exocyst complex component 5",null,"EXOC5"]
["21.1644",1,"21.3014","20.3769",{"$nulls":3},"post-translational protein modification;protein catabolic process;protein deubiquitination;protein ubiquitination;ubiquitin-dependent protein catabolic process","NEDD8-specific protease activity;peptidase activity;thiol-dependent ubiquitin-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitin binding","cytoplasm;cytosol;extracellular exosome;nucleus",{"$nulls":3},4,4,4,"22.6","22.6","22.6","26.182",0,"12.92",122130000,6,"0.360841",1,"-9.75696","-0.966728","sp|P15374|UCHL3_HUMAN;tr|A0A087WTB8|A0A087WTB8_HUMAN;tr|Q5TBK7|Q5TBK7_HUMAN","sp|P15374|UCHL3_HUMAN;tr|A0A087WTB8|A0A087WTB8_HUMAN;tr|Q5TBK7|Q5TBK7_HUMAN",1061,"P15374","UCHL3_HUMAN","Ubiquitin carboxyl-terminal hydrolase isozyme L3","CH-L3","UCHL3"]
["18.7099",1,"19.588","19.6473",{"$nulls":3},"antimicrobial humoral immune response mediated by antimicrobial peptide;cellular response to reactive oxygen species;cytolysis in other organism;defense response to bacterium;defense response to Gram-negative bacterium;defense response to Gram-positive bacterium;killing of cells of other organism;positive regulation of cell proliferation;positive regulation of reactive oxygen species metabolic process;replicative cell aging",null,"integral component of membrane;mitochondrial inner membrane;mitochondrion",{"$nulls":3},1,1,1,"21.5","21.5","21.5","8.1828","0.00069686","4.8262",17355000,8,"0.414351",1,"-9.76274","-1.10251","sp|P60602|ROMO1_HUMAN","sp|P60602|ROMO1_HUMAN",1810,"P60602","ROMO1_HUMAN","Reactive oxygen species modulator 1","OS modulator 1","ROMO1"]
[1,"21.5594","20.703","21.4963",{"$nulls":4},"actin binding",{"$nulls":4},4,4,4,"5.3","5.3","5.3","130.17","0.00023952","5.4605",1259200000,11,"0.356016",1,"-9.81996","-0.954566","tr|A0A0D9SG04|A0A0D9SG04_HUMAN;sp|Q53SF7|COBL1_HUMAN;tr|A0A0B4J1Z0|A0A0B4J1Z0_HUMAN","tr|A0A0D9SG04|A0A0D9SG04_HUMAN;sp|Q53SF7|COBL1_HUMAN",2665,"A0A0D9SG04","A0A0D9SG04_HUMAN",null,null,"COBLL1"]
["19.7086",1,"19.9704","20.3891",{"$nulls":3},"SRP-dependent cotranslational protein targeting to membrane","7S RNA binding","signal recognition particle",{"$nulls":3},2,2,2,"22.5","22.5","22.5","13.654",0,"9.7723",59773000,11,"0.393788",1,"-9.82546","-1.0501","tr|A0A087WYR0|A0A087WYR0_HUMAN;sp|P09132|SRP19_HUMAN","tr|A0A087WYR0|A0A087WYR0_HUMAN;sp|P09132|SRP19_HUMAN",941,"A0A087WYR0","A0A087WYR0_HUMAN",null,null,"SRP19"]
["20.0833",1,"19.9102","20.8994",{"$nulls":5},"mitochondrion;nuclear body",{"$nulls":3},2,2,2,"24.8","24.8","24.8","11.909","0.00025329","6.6407",51754000,5,"0.386779",1,"-9.86317","-1.03231","tr|Q5TAQ0|Q5TAQ0_HUMAN;tr|V5IRT4|V5IRT4_HUMAN;sp|Q9BRT2|UQCC2_HUMAN","tr|Q5TAQ0|Q5TAQ0_HUMAN;tr|V5IRT4|V5IRT4_HUMAN;sp|Q9BRT2|UQCC2_HUMAN",3940,"Q5TAQ0","Q5TAQ0_HUMAN",null,null,"UQCC2"]
["20.1094",1,"20.3028","20.5342",{"$nulls":3},"ceramide metabolic process;negative regulation of sphingolipid biosynthetic process",null,"endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane",{"$nulls":3},2,2,1,"24.1","24.1","13.9","12.157",0,"8.6678",135490000,13,"0.386765",1,"-9.86382","-1.03228","tr|F6WST4|F6WST4_HUMAN;tr|A0A0K0K1C5|A0A0K0K1C5_HUMAN;sp|Q9P0S3|ORML1_HUMAN;sp|Q53FV1|ORML2_HUMAN","tr|F6WST4|F6WST4_HUMAN;tr|A0A0K0K1C5|A0A0K0K1C5_HUMAN;sp|Q9P0S3|ORML1_HUMAN;sp|Q53FV1|ORML2_HUMAN",2649,"F6WST4","F6WST4_HUMAN",null,null,"ORMDL1"]
[1,"17.6623","19.2909","19.1372",{"$nulls":4},"ATP binding",{"$nulls":4},1,1,1,"10.7","10.7","10.7","17.87","0.0085321","2.3243",15814000,2,"0.446896",1,"-9.88292","-1.18621","tr|I3L531|I3L531_HUMAN;sp|P53384|NUBP1_HUMAN","tr|I3L531|I3L531_HUMAN;sp|P53384|NUBP1_HUMAN",1711,"I3L531","I3L531_HUMAN",null,null,"NUBP1"]
["20.6465",1,"21.0072","20.5736",{"$nulls":3},"ATP biosynthetic process;cristae formation;mitochondrial ATP synthesis coupled proton transport;proton transport","transmembrane transporter activity","extracellular exosome;integral component of membrane;mitochondrial inner membrane;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);mitochondrion;nucleoplasm;nucleus","Metabolic pathways;Oxidative phosphorylation;Thermogenesis",null,null,3,1,1,"39.4","13.8","13.8","10.918","0.0015106","3.6461",160550000,10,"0.379711",1,"-9.96712","-1.0144","sp|P56134|ATPK_HUMAN;tr|C9JJT5|C9JJT5_HUMAN;tr|C9JU26|C9JU26_HUMAN","sp|P56134|ATPK_HUMAN;tr|C9JJT5|C9JJT5_HUMAN;tr|C9JU26|C9JU26_HUMAN",1775,"P56134","ATPK_HUMAN","ATP synthase subunit f, mitochondrial",null,"ATP5J2"]
["21.3773",1,"21.3956","21.0126",{"$nulls":4},"RNA binding;zinc ion binding",{"$nulls":4},5,5,5,"42.3","42.3","42.3","15.763",0,"17.09",296190000,25,"0.367221",1,"-10.0154","-0.982824","tr|A0A0B4J1Z1|A0A0B4J1Z1_HUMAN;tr|C9JAB2|C9JAB2_HUMAN;sp|Q16629|SRSF7_HUMAN","tr|A0A0B4J1Z1|A0A0B4J1Z1_HUMAN;tr|C9JAB2|C9JAB2_HUMAN;sp|Q16629|SRSF7_HUMAN",2557,"A0A0B4J1Z1","A0A0B4J1Z1_HUMAN",null,null,"SRSF7"]
[1,"20.1489","20.9932","20.1905",{"$nulls":3},"vacuolar transport",null,"intracellular",{"$nulls":3},1,1,1,"11.5","11.5","11.5","12.939","0.0006728","4.1966",50146000,5,"0.391914",1,"-10.0174","-1.04534","tr|I3L3E4|I3L3E4_HUMAN;tr|I3L4G8|I3L4G8_HUMAN;sp|Q96FZ7|CHMP6_HUMAN;tr|I3L4A1|I3L4A1_HUMAN","tr|I3L3E4|I3L3E4_HUMAN;tr|I3L4G8|I3L4G8_HUMAN;sp|Q96FZ7|CHMP6_HUMAN;tr|I3L4A1|I3L4A1_HUMAN",3689,"I3L3E4","I3L3E4_HUMAN",null,null,"CHMP6"]
["20.9087",1,"21.5167","20.4956",{"$nulls":3},"lipid storage",null,"integral component of membrane",{"$nulls":3},1,1,1,"23.2","23.2","23.2","11.124","0.00023524","5.0819",21092000,1,"0.377364",1,"-10.0518","-1.00846","tr|E9PRU2|E9PRU2_HUMAN;tr|F8W7Q8|F8W7Q8_HUMAN;sp|Q96G97|BSCL2_HUMAN","tr|E9PRU2|E9PRU2_HUMAN;tr|F8W7Q8|F8W7Q8_HUMAN;sp|Q96G97|BSCL2_HUMAN",3695,"E9PRU2","E9PRU2_HUMAN",null,null,"BSCL2"]
["20.849",1,"21.2323","21.0997",{"$nulls":9},1,1,1,"7.1","7.1","7.1","11.269","0.0080016","2.3925",118820000,6,"0.386626",1,"-10.2415","-1.03192","tr|C9JP03|C9JP03_HUMAN;tr|Q5T6P2|Q5T6P2_HUMAN;tr|C9JD09|C9JD09_HUMAN;tr|C9JUW9|C9JUW9_HUMAN;tr|X6RDJ2|X6RDJ2_HUMAN;tr|Q5T6P1|Q5T6P1_HUMAN;tr|X6RGK9|X6RGK9_HUMAN;tr|A0A0C4DFN6|A0A0C4DFN6_HUMAN;sp|Q8ND83|SLAI1_HUMAN;tr|A0A0A0MSS3|A0A0A0MSS3_HUMAN","tr|C9JP03|C9JP03_HUMAN;tr|Q5T6P2|Q5T6P2_HUMAN;tr|C9JD09|C9JD09_HUMAN;tr|C9JUW9|C9JUW9_HUMAN;tr|X6RDJ2|X6RDJ2_HUMAN;tr|Q5T6P1|Q5T6P1_HUMAN;tr|X6RGK9|X6RGK9_HUMAN;tr|A0A0C4DFN6|A0A0C4DFN6_HUMAN;sp|Q8ND83|SLAI1_HUMAN;tr|A0A0A0MSS3|A0A0A0MSS3_HUMAN",3314,"C9JP03","C9JP03_HUMAN",null,null,"SLAIN1"]
["21.2619",1,"21.3189","21.483",{"$nulls":3},"alpha-linolenic acid metabolic process;fatty acid elongation, monounsaturated fatty acid;fatty acid elongation, polyunsaturated fatty acid;fatty acid elongation, saturated fatty acid;linoleic acid metabolic process;long-chain fatty-acyl-CoA biosynthetic process;positive regulation of fatty acid biosynthetic process;sphingolipid biosynthetic process;unsaturated fatty acid biosynthetic process;very long-chain fatty acid biosynthetic process","3-oxo-arachidoyl-CoA synthase activity;3-oxo-cerotoyl-CoA synthase activity;3-oxo-lignoceronyl-CoA synthase activity;fatty acid elongase activity;very-long-chain 3-ketoacyl-CoA synthase activity","dendrite;dendritic tree;endoplasmic reticulum;endoplasmic reticulum membrane;integral component of endoplasmic reticulum membrane;membrane;neuronal cell body","Biosynthesis of unsaturated fatty acids;Fatty acid elongation;Fatty acid metabolism;Metabolic pathways",null,null,2,2,2,"12.7","12.7","12.7","35.293",0,"53.521",410850000,12,"0.379432",1,"-10.27","-1.01369","sp|Q9NYP7|ELOV5_HUMAN;tr|A0A0A0MTI6|A0A0A0MTI6_HUMAN","sp|Q9NYP7|ELOV5_HUMAN;tr|A0A0A0MTI6|A0A0A0MTI6_HUMAN",4572,"Q9NYP7","ELOV5_HUMAN","Elongation of very long chain fatty acids protein 5 {ECO:0000255|HAMAP-Rule:MF_03205, ECO:0000305}",null,"ELOVL5"]
["21.4779",1,"21.5529","21.59",{"$nulls":3},"chemotaxis;cytokine-mediated signaling pathway;ion transport","chemokine binding;ion transmembrane transporter activity","endoplasmic reticulum;endoplasmic reticulum membrane;extracellular exosome;integral component of membrane;membrane;plasma membrane",{"$nulls":3},1,1,1,"8.6","8.6","8.6","16.691",0,"14.675",90886000,5,"0.377629",1,"-10.3325","-1.00913","sp|Q04941|PLP2_HUMAN","sp|Q04941|PLP2_HUMAN",2097,"Q04941","PLP2_HUMAN","Proteolipid protein 2",null,"PLP2"]
["21.1108",1,"21.1553","21.6294",{"$nulls":3},"cristae formation",null,"cytosol;MICOS complex;mitochondrion",{"$nulls":3},3,3,3,"28.7","28.7","28.7","20.08",0,"15.085",152300000,9,"0.384966",1,"-10.337","-1.02771","tr|H7C1U8|H7C1U8_HUMAN;sp|Q9BUR5|MIC26_HUMAN;tr|G3V1B6|G3V1B6_HUMAN;tr|A0A0J9YXS4|A0A0J9YXS4_HUMAN","tr|H7C1U8|H7C1U8_HUMAN;sp|Q9BUR5|MIC26_HUMAN;tr|G3V1B6|G3V1B6_HUMAN",3994,"H7C1U8","H7C1U8_HUMAN","MICOS complex subunit {ECO:0000256|RuleBase:RU363021}",null,"APOO"]
["17.8248",1,"20.3124","19.2674",{"$nulls":3},"axon guidance;microtubule-based process;mitotic cell cycle","GTP binding;GTPase activity;peptide binding;structural constituent of cytoskeleton","axon;cell periphery;cytoplasm;dendrite;extracellular exosome;microtubule;microtubule cytoskeleton;neuronal cell body;nucleus","Gap junction;Pathogenic Escherichia coli infection;Phagosome",null,null,18,5,3,46,"20.2","15.6","50.432",0,"15.462",74166000,9,"0.464234",1,"-10.3775","-1.23123","sp|Q13509|TBB3_HUMAN;tr|A0A0B4J269|A0A0B4J269_HUMAN;tr|G3V2A3|G3V2A3_HUMAN;tr|G3V5W4|G3V5W4_HUMAN;tr|G3V2R8|G3V2R8_HUMAN;tr|G3V3R4|G3V3R4_HUMAN;tr|G3V2N6|G3V2N6_HUMAN;tr|G3V3J6|G3V3J6_HUMAN;tr|G3V3W7|G3V3W7_HUMAN","sp|Q13509|TBB3_HUMAN;tr|A0A0B4J269|A0A0B4J269_HUMAN",2270,"Q13509","TBB3_HUMAN","Tubulin beta-3 chain",null,"TUBB3"]
["16.3602",1,"22.603","15.968",{"$nulls":3},"chromatin silencing","DNA binding;protein heterodimerization activity","extracellular exosome;nuclear chromatin;nucleosome;nucleus","Alcoholism;Necroptosis;Systemic lupus erythematosus",null,null,5,1,1,55,"22.5","22.5","13.988",0,"28.196",202870000,19,"0.478177",1,"-10.6054","-1.26768","sp|Q16777|H2A2C_HUMAN;sp|Q6FI13|H2A2A_HUMAN","sp|Q16777|H2A2C_HUMAN;sp|Q6FI13|H2A2A_HUMAN",2573,"Q16777","H2A2C_HUMAN","Histone H2A type 2-C",null,"HIST2H2AC"]
["22.3879",1,"22.9148","22.3106",{"$nulls":3},"ATP biosynthetic process;ATP synthesis coupled proton transport;cristae formation;mitochondrial ATP synthesis coupled proton transport;oxidative phosphorylation;response to copper ion","ATPase activity;proton-transporting ATP synthase activity, rotational mechanism;transmembrane transporter activity;transporter activity","mitochondrial inner membrane;mitochondrial matrix;mitochondrial proton-transporting ATP synthase complex;mitochondrial proton-transporting ATP synthase complex, catalytic core F(1);mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Oxidative phosphorylation;Parkinson disease;Thermogenesis",null,null,2,2,2,"13.7","13.7","13.7","17.49",0,"16.755",195080000,5,"0.382164",1,"-10.9188","-1.02061","sp|P30049|ATPD_HUMAN","sp|P30049|ATPD_HUMAN",1298,"P30049","ATPD_HUMAN","ATP synthase subunit delta, mitochondrial",null,"ATP5D"]
[1,"15.2651","19.4487","18.8577",{"$nulls":3},"protein tetramerization;UDP-D-xylose biosynthetic process","NAD+ binding;protein homodimerization activity;UDP-glucuronate decarboxylase activity","cytoplasm;extracellular exosome;Golgi cisterna membrane;integral component of membrane;mitochondrion","Amino sugar and nucleotide sugar metabolism;Metabolic pathways",null,null,10,10,10,"39.8","39.8","39.8","47.576",0,"52.643",421500000,44,"0.580665",1,"-11.0206","-1.54379","sp|Q8NBZ7|UXS1_HUMAN;tr|C9JCB7|C9JCB7_HUMAN;tr|C9JFU6|C9JFU6_HUMAN;tr|C9JE50|C9JE50_HUMAN;tr|C9JW33|C9JW33_HUMAN;tr|C9J3T9|C9J3T9_HUMAN","sp|Q8NBZ7|UXS1_HUMAN",3297,"Q8NBZ7","UXS1_HUMAN","UDP-glucuronic acid decarboxylase 1",null,"UXS1"]
["19.1562",1,"19.7025","24.7597",{"$nulls":5},"Golgi apparatus;nucleolus",{"$nulls":3},2,2,2,"6.4","6.4","6.4","49.038",0,"11.898",727130000,4,"0.486527",1,"-12.153","-1.28962","tr|B4DJV5|B4DJV5_HUMAN;sp|Q13610|PWP1_HUMAN","tr|B4DJV5|B4DJV5_HUMAN;sp|Q13610|PWP1_HUMAN",2289,"B4DJV5","B4DJV5_HUMAN",null,null,"PWP1"]
[1,1,"13.7502","13.8112",{"$nulls":4},"chromatin binding","cytosol;mitochondrion;nuclear membrane;nucleus",{"$nulls":3},5,5,5,"2.6","2.6","2.6","314.46","0.00025767","7.0243",67700000,5,"5.24464",1,"-12.7807","-419.099","tr|H9KVB4|H9KVB4_HUMAN;sp|O15417|TNC18_HUMAN;tr|H7C0N9|H7C0N9_HUMAN","tr|H9KVB4|H9KVB4_HUMAN;sp|O15417|TNC18_HUMAN",363,"H9KVB4","H9KVB4_HUMAN",null,null,"TNRC18"]
[1,1,"13.6911","15.5546",{"$nulls":3},"chromosome separation;female meiosis chromosome segregation;meiotic spindle assembly checkpoint;mitotic spindle assembly checkpoint;mitotic spindle organization;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of cell proliferation;positive regulation of pathway-restricted SMAD protein phosphorylation;protein autophosphorylation;protein localization to kinetochore;protein localization to meiotic spindle midzone;spindle organization","ATP binding;protein homodimerization activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity","cytoplasm;kinetochore;membrane;spindle","Cell cycle",null,null,8,8,8,"15.5","15.5","15.5","97.071",0,"19.63",154050000,19,"2.33298",1,"-13.6228","-14.6209","sp|P33981|TTK_HUMAN;tr|D6RF82|D6RF82_HUMAN;tr|D6REX1|D6REX1_HUMAN;tr|D6RIC6|D6RIC6_HUMAN","sp|P33981|TTK_HUMAN",1360,"P33981","TTK_HUMAN","Dual specificity protein kinase TTK",null,"TTK"]
[1,1,"15.2979","14.9874",{"$nulls":3},"cation transport;cellular response to heat;chloride transmembrane transport;chloride transport;detection of temperature stimulus involved in sensory perception of pain;iodide transport;ion transmembrane transport;multicellular organism development;phospholipase C-activating G-protein coupled receptor signaling pathway;positive regulation of insulin secretion involved in cellular response to glucose stimulus","calcium activated cation channel activity;chloride channel activity;intracellular calcium activated chloride channel activity;iodide transmembrane transporter activity;protein dimerization activity;voltage-gated chloride channel activity","apical plasma membrane;chloride channel complex;cytoplasm;extracellular exosome;plasma membrane",{"$nulls":3},8,8,8,"6.7","6.7","6.7","114.08",0,"10.625",126860000,11,"3.91889",1,"-14.1426","-91.0763","sp|Q5XXA6|ANO1_HUMAN;tr|E9PP68|E9PP68_HUMAN;tr|H0YDD9|H0YDD9_HUMAN;tr|E9PNA7|E9PNA7_HUMAN;tr|E9PS90|E9PS90_HUMAN","sp|Q5XXA6|ANO1_HUMAN;tr|E9PP68|E9PP68_HUMAN;tr|H0YDD9|H0YDD9_HUMAN",2777,"Q5XXA6","ANO1_HUMAN","Anoctamin-1",null,"ANO1"]
[1,1,"14.8811","15.4392",{"$nulls":9},2,2,2,"1.3","1.3","1.3","237.3","0.0006643","4.0461",215350000,11,"3.41103",1,"-14.1602","-50.7442","sp|Q5THK1|PR14L_HUMAN;tr|C9J9V0|C9J9V0_HUMAN;tr|H7C1B0|H7C1B0_HUMAN;tr|H3BLU3|H3BLU3_HUMAN;sp|Q9BWN1|PRR14_HUMAN","sp|Q5THK1|PR14L_HUMAN;tr|C9J9V0|C9J9V0_HUMAN;tr|H7C1B0|H7C1B0_HUMAN;tr|H3BLU3|H3BLU3_HUMAN;sp|Q9BWN1|PRR14_HUMAN",2747,"Q5THK1","PR14L_HUMAN","Protein PRR14L",null,"PRR14L"]
[1,1,"15.2558","15.4471",{"$nulls":3},"cell cycle;cellular response to ATP;cellular response to DNA damage stimulus;cellular response to UV;DNA-templated transcription, initiation;midbrain development;negative regulation of gene expression;negative regulation of protein autoubiquitination;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of androgen receptor activity;positive regulation of cell proliferation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein binding;positive regulation of transcription from RNA polymerase I promoter;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription initiation from RNA polymerase II promoter;protein autophosphorylation;protein phosphorylation;protein polyubiquitination;protein stabilization;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of cell cycle G1/S phase transition;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage;regulation of transcription initiation from RNA polymerase II promoter;RNA polymerase II transcriptional preinitiation complex assembly;transcription elongation from RNA polymerase II promoter;transcription factor catabolic process;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;viral process","ATP binding;histone acetyltransferase activity;kinase activity;lysine-acetylated histone binding;p53 binding;protein heterodimerization activity;protein serine/threonine kinase activity;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly;sequence-specific DNA binding;TBP-class protein binding;transcription coactivator activity;transcription factor binding;ubiquitin conjugating enzyme activity","MLL1 complex;nuclear chromatin;nucleoplasm;nucleus;transcription factor complex;transcription factor TFIID complex","Basal transcription factors",null,null,14,14,6,"11.3","11.3","4.6","212.67",0,"43.093",335250000,55,"4.35286",1,"-14.3514","-150.111","sp|P21675|TAF1_HUMAN;tr|H7BY98|H7BY98_HUMAN;tr|H7C2K9|H7C2K9_HUMAN;tr|H0Y9L7|H0Y9L7_HUMAN","sp|P21675|TAF1_HUMAN",1167,"P21675","TAF1_HUMAN","Transcription initiation factor TFIID subunit 1",null,"TAF1"]
[1,1,"15.8264","15.8635",{"$nulls":3},"actin filament organization;negative regulation of small GTPase mediated signal transduction","motor activity","bicellular tight junction;myosin complex","Tight junction",null,null,2,2,2,"1.8","1.8","1.8","149.08","0.0090559","2.2554",18223000,3,"5.80741",1,"-14.845","-801.136","sp|Q0VF96|CGNL1_HUMAN","sp|Q0VF96|CGNL1_HUMAN",2146,"Q0VF96","CGNL1_HUMAN","Cingulin-like protein 1",null,"CGNL1"]
[1,1,"16.2211","16.3152",{"$nulls":3},"negative regulation of transmembrane transport;negative regulation of transporter activity;protein dephosphorylation","protein phosphatase 2A binding","actin cytoskeleton;cytoplasm",{"$nulls":3},2,2,2,"6.6","6.6","6.6","70.157","0.0037244","3.0981",49557000,4,"5.02238",1,"-15.2681","-324.479","sp|Q9P2B4|CT2NL_HUMAN","sp|Q9P2B4|CT2NL_HUMAN",4638,"Q9P2B4","CT2NL_HUMAN","CTTNBP2 N-terminal-like protein",null,"CTTNBP2NL"]
[1,1,"15.9386","17.1153",{"$nulls":4},"zinc ion binding","nucleoplasm",{"$nulls":3},4,4,3,"10.6","10.6","7.8","50.403",0,"8.4553",67203000,4,"2.84381",1,"-15.527","-26.3899","tr|B3KPJ4|B3KPJ4_HUMAN;tr|A0A0A0MSI2|A0A0A0MSI2_HUMAN;sp|Q8IXK0|PHC2_HUMAN","tr|B3KPJ4|B3KPJ4_HUMAN;tr|A0A0A0MSI2|A0A0A0MSI2_HUMAN;sp|Q8IXK0|PHC2_HUMAN",3147,"B3KPJ4","B3KPJ4_HUMAN",null,null,"PHC2"]
[1,1,"16.6392","16.9374",{"$nulls":3},"histone H3-K4 methylation",null,"Set1C/COMPASS complex",{"$nulls":3},1,1,1,"3.9","3.9","3.9","55.324","0.00066269","3.9991",49469000,5,"4.04965",1,"-15.7883","-105.876","tr|F5H8F7|F5H8F7_HUMAN;sp|Q9UBL3|ASH2L_HUMAN","tr|F5H8F7|F5H8F7_HUMAN;sp|Q9UBL3|ASH2L_HUMAN",4665,"F5H8F7","F5H8F7_HUMAN",null,null,"ASH2L"]
[1,1,"16.5096","17.3986",{"$nulls":3},"negative regulation of phosphatase activity","phosphatase binding","cytosol",{"$nulls":3},1,1,1,"2.6","2.6","2.6","52.726","0.004881","2.859",10423000,2,"3.1105",1,"-15.9541","-35.8921","sp|Q9H788|SH24A_HUMAN","sp|Q9H788|SH24A_HUMAN",4238,"Q9H788","SH24A_HUMAN","SH2 domain-containing protein 4A",null,"SH2D4A"]
[1,1,"17.2085","17.981",{"$nulls":3},"intracellular signal transduction;Wnt signaling pathway",null,"aggresome;nuclear body;nucleoplasm",{"$nulls":3},3,3,3,"5.6","5.6","5.6","78.375","0.00025753","7.0218",43727000,5,"3.26656",1,"-16.5947","-42.9641","tr|I3L2N2|I3L2N2_HUMAN;sp|O14641|DVL2_HUMAN;tr|I3L2W9|I3L2W9_HUMAN;tr|I3L0Z8|I3L0Z8_HUMAN","tr|I3L2N2|I3L2N2_HUMAN;sp|O14641|DVL2_HUMAN;tr|I3L2W9|I3L2W9_HUMAN",269,"I3L2N2","I3L2N2_HUMAN",null,null,"DVL2"]
[1,1,"17.3632","17.9644",{"$nulls":3},"cellular hyperosmotic response;cellular response to glucose starvation;cellular response to mechanical stimulus;cerebral cortex development;female pregnancy;glucose transmembrane transport;glucose transport;lactose biosynthetic process;L-ascorbic acid metabolic process;protein complex assembly;regulation of glucose transport;regulation of insulin secretion;response to insulin;response to Thyroglobulin triiodothyronine","dehydroascorbic acid transmembrane transporter activity;D-glucose transmembrane transporter activity;glucose transmembrane transporter activity;identical protein binding;kinase binding;protein self-association;xenobiotic transmembrane transporter activity","apical plasma membrane;basolateral plasma membrane;blood microparticle;caveola;cortical actin cytoskeleton;cytosol;extracellular exosome;female pronucleus;Golgi membrane;integral component of plasma membrane;intercalated disc;melanosome;membrane;midbody;plasma membrane;sarcolemma;Z disc","Adipocytokine signaling pathway;Bile secretion;Central carbon metabolism in cancer;Glucagon signaling pathway;HIF-1 signaling pathway;Human T-cell leukemia virus 1 infection;Insulin resistance;Insulin secretion;Pathways in cancer;Renal cell carcinoma;Thyroid hormone signaling pathway",null,null,2,2,2,"5.1","5.1","5.1","54.083","0.00087893","3.9267",13571000,2,"3.4878",1,"-16.6638","-55.4365","sp|P11166|GTR1_HUMAN","sp|P11166|GTR1_HUMAN",984,"P11166","GTR1_HUMAN","Solute carrier family 2, facilitated glucose transporter member 1",null,"SLC2A1"]
[1,1,"17.548","17.8671",{"$nulls":3},"base-excision repair","catalytic activity;DNA binding",{"$nulls":4},1,1,1,"7.8","7.8","7.8","23.717","0.0023212","3.3581",12980000,2,"4.04011",1,"-16.7076","-104.718","tr|H3BRL9|H3BRL9_HUMAN;sp|P78549|NTH_HUMAN","tr|H3BRL9|H3BRL9_HUMAN;sp|P78549|NTH_HUMAN",1983,"H3BRL9","H3BRL9_HUMAN",null,null,"NTHL1"]
[1,1,"18.2713","17.534",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","metal ion binding;RNA binding;rRNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit","Ribosome",null,null,2,2,2,"17.5","17.5","17.5","11.078","0.0015009","3.5444",49955000,10,"3.3231",1,"-16.9026","-45.8558","sp|P61927|RL37_HUMAN;tr|D6RG19|D6RG19_HUMAN","sp|P61927|RL37_HUMAN;tr|D6RG19|D6RG19_HUMAN",1859,"P61927","RL37_HUMAN","60S ribosomal protein L37",null,"RPL37"]
[1,1,"18.9579","17.1951",{"$nulls":3},"ribosomal large subunit biogenesis","RNA binding","intracellular membrane-bounded organelle;nucleolus;nucleus",{"$nulls":3},9,9,9,"50.6","50.6","50.6","21.188",0,"36.431",563520000,77,"2.57619",1,"-17.0765","-19.3744","sp|Q9Y3C1|NOP16_HUMAN;tr|D6RIC3|D6RIC3_HUMAN;tr|A0A0C4DGU5|A0A0C4DGU5_HUMAN;tr|A0A087X2G6|A0A087X2G6_HUMAN;tr|A0A087X1T1|A0A087X1T1_HUMAN;tr|D6RC60|D6RC60_HUMAN;tr|A0A087WU10|A0A087WU10_HUMAN","sp|Q9Y3C1|NOP16_HUMAN;tr|D6RIC3|D6RIC3_HUMAN;tr|A0A0C4DGU5|A0A0C4DGU5_HUMAN;tr|A0A087X2G6|A0A087X2G6_HUMAN;tr|A0A087X1T1|A0A087X1T1_HUMAN",4978,"Q9Y3C1","NOP16_HUMAN","Nucleolar protein 16",null,"NOP16"]
[1,1,"18.1188","19.6573",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,2,2,2,"18.2","18.2","18.2","16.402","0.00023992","5.4976",10157000,3,"2.7342",1,"-17.8881","-23.2541","sp|P17568|NDUB7_HUMAN","sp|P17568|NDUB7_HUMAN",1101,"P17568","NDUB7_HUMAN","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7",null,"NDUFB7"]
[1,1,"19.3172","18.6729",{"$nulls":3},"one-carbon metabolic process;phosphatidylinositol-mediated signaling","carbonate dehydratase activity;zinc ion binding","cytoplasm","Metabolic pathways;Nitrogen metabolism",null,null,2,2,2,11,11,11,"32.973","0.00025517","6.8187",31542000,5,"3.49444",1,"-17.9951","-55.8616","sp|P35219|CAH8_HUMAN","sp|P35219|CAH8_HUMAN",1370,"P35219","CAH8_HUMAN","Carbonic anhydrase-related protein","ARP","CA8"]
[1,1,"19.0832","19.3124",{"$nulls":4},"GTP binding",{"$nulls":4},5,5,5,"30.9","30.9","30.9","26.422",0,"9.3518",117790000,14,"4.4019",1,"-18.1978","-158.832","sp|Q5HYI8|RABL3_HUMAN;tr|C9JXM3|C9JXM3_HUMAN;tr|F8WF50|F8WF50_HUMAN;tr|F8WDC7|F8WDC7_HUMAN;tr|H7C533|H7C533_HUMAN;tr|F8WAX9|F8WAX9_HUMAN","sp|Q5HYI8|RABL3_HUMAN;tr|C9JXM3|C9JXM3_HUMAN",2689,"Q5HYI8","RABL3_HUMAN","Rab-like protein 3",null,"RABL3"]
[1,1,"19.9049","18.6078",{"$nulls":3},"proteasome assembly",{"$nulls":5},1,1,1,"23.1","23.1","23.1","11.655","0.00046838","4.9495",29255000,7,"2.89973",1,"-18.2563","-28.1485","tr|D6RB92|D6RB92_HUMAN;sp|Q5JS54|PSMG4_HUMAN","tr|D6RB92|D6RB92_HUMAN;sp|Q5JS54|PSMG4_HUMAN",2696,"D6RB92","D6RB92_HUMAN",null,null,"PSMG4"]
[1,1,"18.7576","19.9066",{"$nulls":9},2,2,2,"21.1","21.1","21.1","13.148","0.0002471","6.1509",23881000,5,"3.00848",1,"-18.3321","-31.9095","tr|M0R2P8|M0R2P8_HUMAN;tr|M0R3A4|M0R3A4_HUMAN;tr|M0QYA2|M0QYA2_HUMAN;sp|Q9NWS0|PIHD1_HUMAN;tr|M0QYF4|M0QYF4_HUMAN;tr|M0QXD5|M0QXD5_HUMAN","tr|M0R2P8|M0R2P8_HUMAN;tr|M0R3A4|M0R3A4_HUMAN;tr|M0QYA2|M0QYA2_HUMAN;sp|Q9NWS0|PIHD1_HUMAN;tr|M0QYF4|M0QYF4_HUMAN;tr|M0QXD5|M0QXD5_HUMAN",4516,"M0R2P8","M0R2P8_HUMAN",null,null,"PIH1D1"]
[1,1,"18.2896","20.5724",{"$nulls":3},"mRNA transport;negative regulation of vascular endothelial growth factor production;positive regulation of protein import into nucleus;protein export from nucleus;protein import into nucleus;protein import into nucleus, translocation;protein localization to nuclear pore","identical protein binding;nucleocytoplasmic transporter activity;protein transporter activity;Ran GTPase binding","cytosol;extracellular exosome;nuclear inner membrane;nuclear membrane;nuclear outer membrane;nuclear pore central transport channel;nucleoplasm",{"$nulls":3},2,2,2,"17.3","17.3","17.3","14.478","0.00069109","4.6529",17361000,2,"2.41872",1,"-18.431","-16.1479","sp|P61970|NTF2_HUMAN;tr|H3BRV9|H3BRV9_HUMAN","sp|P61970|NTF2_HUMAN;tr|H3BRV9|H3BRV9_HUMAN",1865,"P61970","NTF2_HUMAN","Nuclear transport factor 2 {ECO:0000303|PubMed:7744965}","TF-2","NUTF2"]
[1,1,"20.1302","21.0102",{"$nulls":9},1,1,1,"64.3","64.3","64.3","2.9523","0.0015138","3.6755",15381000,4,"3.29656",1,"-19.5702","-44.4748","tr|F8W6F4|F8W6F4_HUMAN;tr|B1AHC2|B1AHC2_HUMAN;tr|B1AHF8|B1AHF8_HUMAN;tr|F8WCV8|F8WCV8_HUMAN;sp|P85298|RHG08_HUMAN","tr|F8W6F4|F8W6F4_HUMAN;tr|B1AHC2|B1AHC2_HUMAN;tr|B1AHF8|B1AHF8_HUMAN;tr|F8WCV8|F8WCV8_HUMAN;sp|P85298|RHG08_HUMAN",2016,"F8W6F4","F8W6F4_HUMAN",null,null,"ARHGAP8"]

{"sheet":"LS174T_Signproteins_3DsiKvssiC","index":5,"n_rows":52,"n_cols":36,"rows_kept":52}
["3D siKRAS 2 ","3D siKRAS 1","3D NT  2","3D NT 1","C: Only identified by site","C: Reverse","C: Potential contaminant","C: GOBP name","C: GOMF name","C: GOCC name","C: KEGG pathway name","C: Student's T-test Significant 3D siKRAS_2D siKRAS","C: Student's T-test significant","N: Peptides","N: Razor + unique peptides","N: Unique peptides","N: Sequence coverage [%]","N: Unique + razor sequence coverage [%]","N: Unique sequence coverage [%]","N: Mol. weight [kDa]","N: Q-value","N: Score","N: Intensity","N: MS/MS Count","N: -Log Student's T-test p-value 3D siKRAS_2D siKRAS","N: Student's T-test q-value 3D siKRAS_2D siKRAS","N: Student's T-test Difference 3D siKRAS_2D siKRAS","N: Student's T-test Test statistic 3D siKRAS_2D siKRAS","T: Protein IDs","T: Majority protein IDs","T: id","T: Uniprot IDs","T: Uniprot name","T: Uniprot full protein name","T: Uniprot short protein name","T: Gene name"]
["20.1228","19.9216",1,1,{"$nulls":3},"cellular defense response",{"$nulls":5},1,1,1,"30.2","30.2","30.2","12.763","0.008168","2.3581",11502000,3,"4.5534",1,"19.0222","189.099","sp|Q9UEU5|GGE2D_HUMAN;sp|Q6NT46|GAG2A_HUMAN;sp|Q4V326|GAG2E_HUMAN;sp|Q13066|GAG2B_HUMAN;tr|A0A087X111|A0A087X111_HUMAN","sp|Q9UEU5|GGE2D_HUMAN;sp|Q6NT46|GAG2A_HUMAN;sp|Q4V326|GAG2E_HUMAN;sp|Q13066|GAG2B_HUMAN;tr|A0A087X111|A0A087X111_HUMAN",2199,"Q9UEU5","GGE2D_HUMAN","G antigen 2D","AGE-2D","GAGE2D;GAGE8"]
["20.2477","19.4158",1,1,{"$nulls":3},"chromosome segregation;histone methylation;N-terminal peptidyl-alanine methylation;N-terminal peptidyl-alanine trimethylation;N-terminal peptidyl-glycine methylation;N-terminal peptidyl-proline dimethylation;N-terminal peptidyl-serine dimethylation;N-terminal peptidyl-serine trimethylation;spindle organization","histone methyltransferase activity;N-terminal protein N-methyltransferase activity;protein methyltransferase activity","cytoplasm;cytosol;nucleoplasm;nucleus",{"$nulls":3},2,2,2,"11.2","11.2","11.2","25.387",0,"14.264",43686000,3,"3.312",1,"18.8318","45.2733","sp|Q9BV86|NTM1A_HUMAN;tr|S4R344|S4R344_HUMAN;tr|S4R3J7|S4R3J7_HUMAN","sp|Q9BV86|NTM1A_HUMAN;tr|S4R344|S4R344_HUMAN;tr|S4R3J7|S4R3J7_HUMAN",4003,"Q9BV86","NTM1A_HUMAN","N-terminal Xaa-Pro-Lys N-methyltransferase 1",null,"NTMT1"]
["18.998","19.5824",1,1,{"$nulls":4},"structural constituent of myelin sheath",{"$nulls":4},2,2,2,"38.4","38.4","38.4","17.442","0.002924","3.233",10702000,3,"3.59321",1,"18.2902","62.5927","tr|J3KS94|J3KS94_HUMAN;tr|J3QQK6|J3QQK6_HUMAN;sp|P02686|MBP_HUMAN","tr|J3KS94|J3KS94_HUMAN;tr|J3QQK6|J3QQK6_HUMAN;sp|P02686|MBP_HUMAN",822,"J3KS94","J3KS94_HUMAN",null,null,"MBP"]
["17.1793","18.2731",1,1,{"$nulls":3},"CDP-diacylglycerol biosynthetic process;phosphatidic acid biosynthetic process;phospholipid biosynthetic process","1-acylglycerol-3-phosphate O-acyltransferase activity","endoplasmic reticulum;endoplasmic reticulum membrane;Golgi membrane;integral component of membrane;membrane;nuclear envelope;plasma membrane","Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phospholipase D signaling pathway",null,null,1,1,1,"2.7","2.7","2.7","43.38","0.0029264","3.2356",26286000,2,"2.97171",1,"16.7262","30.585","sp|Q9NRZ7|PLCC_HUMAN","sp|Q9NRZ7|PLCC_HUMAN",4433,"Q9NRZ7","PLCC_HUMAN","1-acyl-sn-glycerol-3-phosphate acyltransferase gamma",null,"AGPAT3"]
["17.3185","18.0756",1,1,{"$nulls":4},"hydrolase activity;metal ion binding","extracellular exosome",{"$nulls":3},2,2,2,"12.9","12.9","12.9","31.371","0.00024278","5.7365",19870000,4,"3.2894",1,"16.697","44.1093","sp|Q68D91|MBLC2_HUMAN","sp|Q68D91|MBLC2_HUMAN",2794,"Q68D91","MBLC2_HUMAN","Metallo-beta-lactamase domain-containing protein 2",null,"MBLAC2"]
["16.2506","17.8763",1,1,{"$nulls":3},"protein glycosylation","galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;metal ion binding","Golgi membrane",{"$nulls":3},6,6,6,"21.6","21.6","21.6","34.963",0,"17.818",264170000,15,"2.59328",1,"16.0634","19.7609","tr|G3V150|G3V150_HUMAN;sp|O94766|B3GA3_HUMAN;tr|E9PNA1|E9PNA1_HUMAN","tr|G3V150|G3V150_HUMAN;sp|O94766|B3GA3_HUMAN",650,"G3V150","G3V150_HUMAN","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase {ECO:0000256|RuleBase:RU363127}"]
["16.1279","17.2266",1,1,{"$nulls":3},"adult walking behavior;brain development;cell chemotaxis;chemical synaptic transmission, postsynaptic;desensitization of G-protein coupled receptor protein signaling pathway by arrestin;detection of temperature stimulus involved in sensory perception of pain;dopamine receptor signaling pathway;follicle-stimulating hormone signaling pathway;G-protein coupled receptor internalization;G-protein coupled receptor signaling pathway;membrane organization;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of GTPase activity;negative regulation of interleukin-1 beta production;negative regulation of interleukin-12 production;negative regulation of interleukin-6 production;negative regulation of natural killer cell mediated cytotoxicity;negative regulation of NF-kappaB transcription factor activity;negative regulation of protein kinase B signaling;negative regulation of protein phosphorylation;negative regulation of protein ubiquitination;negative regulation of release of cytochrome c from mitochondria;negative regulation of smooth muscle cell apoptotic process;negative regulation of toll-like receptor signaling pathway;negative regulation of tumor necrosis factor production;platelet activation;positive regulation of calcium ion transport;positive regulation of cardiac muscle cell differentiation;positive regulation of DNA biosynthetic process;positive regulation of ERK1 and ERK2 cascade;positive regulation of gene expression;positive regulation of peptidyl-serine phosphorylation;positive regulation of peptidyl-tyrosine phosphorylation;positive regulation of protein kinase B signaling;positive regulation of protein ubiquitination;positive regulation of receptor internalization;positive regulation of synaptic transmission, dopaminergic;proteasome-mediated ubiquitin-dependent protein catabolic process;protein deubiquitination;protein transport;protein ubiquitination;receptor internalization;regulation of androgen receptor signaling pathway;transcription from RNA polymerase II promoter;transforming growth factor beta receptor signaling pathway;Wnt signaling pathway, planar cell polarity pathway","14-3-3 protein binding;alpha-1A adrenergic receptor binding;alpha-1B adrenergic receptor binding;angiotensin receptor binding;arrestin family protein binding;D1 dopamine receptor binding;enzyme binding;follicle-stimulating hormone receptor binding;G-protein coupled receptor binding;identical protein binding;mitogen-activated protein kinase binding;platelet activating factor receptor binding;protein complex binding;protein complex scaffold activity;protein domain specific binding;protein kinase B binding;receptor binding;type 1 angiotensin receptor binding;type 2A serotonin receptor binding;ubiquitin protein ligase binding","basolateral plasma membrane;clathrin-coated pit;cytoplasm;cytoplasmic vesicle;cytosol;dendritic spine;endocytic vesicle;intracellular membrane-bounded organelle;nucleus;plasma membrane;postsynaptic density;postsynaptic membrane","Chemokine signaling pathway;Dopaminergic synapse;Endocytosis;Hedgehog signaling pathway;MAPK signaling pathway;Morphine addiction;Olfactory transduction;Parathyroid hormone synthesis, secretion and action;Relaxin signaling pathway",null,null,10,10,9,"25.4","25.4","23.7","46.105",0,"24.219",258990000,40,"2.91163",1,"15.6772","28.5375","sp|P32121|ARRB2_HUMAN;tr|Q68DZ5|Q68DZ5_HUMAN;tr|K7ENA6|K7ENA6_HUMAN;tr|I3L412|I3L412_HUMAN;tr|K7EL17|K7EL17_HUMAN;tr|I3L0V6|I3L0V6_HUMAN","sp|P32121|ARRB2_HUMAN;tr|Q68DZ5|Q68DZ5_HUMAN;tr|K7ENA6|K7ENA6_HUMAN",1346,"P32121","ARRB2_HUMAN","Beta-arrestin-2",null,"ARRB2"]
["17.2717","14.7765",1,1,{"$nulls":4},"ATP binding",{"$nulls":4},2,2,2,"2.7","2.7","2.7","117.85","0.0065347","2.5632",10991000,2,"2.16592",1,"15.0241","12.0428","tr|A0A0G2JMG8|A0A0G2JMG8_HUMAN;tr|A0A0G2JLX3|A0A0G2JLX3_HUMAN;tr|J3KN39|J3KN39_HUMAN;tr|A0A0G2JPQ2|A0A0G2JPQ2_HUMAN;sp|Q9NX02|NALP2_HUMAN;tr|K7EMK2|K7EMK2_HUMAN;tr|A0A0G2JPB6|A0A0G2JPB6_HUMAN;tr|A0A0G2JLQ8|A0A0G2JLQ8_HUMAN;tr|A0A0G2JP37|A0A0G2JP37_HUMAN;tr|A0A0G2JNC8|A0A0G2JNC8_HUMAN","tr|A0A0G2JMG8|A0A0G2JMG8_HUMAN;tr|A0A0G2JLX3|A0A0G2JLX3_HUMAN;tr|J3KN39|J3KN39_HUMAN;tr|A0A0G2JPQ2|A0A0G2JPQ2_HUMAN;sp|Q9NX02|NALP2_HUMAN;tr|K7EMK2|K7EMK2_HUMAN;tr|A0A0G2JPB6|A0A0G2JPB6_HUMAN;tr|A0A0G2JLQ8|A0A0G2JLQ8_HUMAN;tr|A0A0G2JP37|A0A0G2JP37_HUMAN;tr|A0A0G2JNC8|A0A0G2JNC8_HUMAN",4528,"A0A0G2JMG8","A0A0G2JMG8_HUMAN",null,null,"NLRP2"]
["15.8213","16.0145",1,1,{"$nulls":3},"apoptotic process;intracellular signal transduction;regulation of JNK cascade;viral process","ATP binding;guanylate kinase activity;protein complex scaffold activity","bicellular tight junction;cell junction;membrane;nucleus;plasma membrane","Rap1 signaling pathway",null,null,4,4,4,4,4,4,"165.61","0.00024349","5.7752",29209000,5,"4.37707",1,"14.9179","154.356","sp|Q5TCQ9|MAGI3_HUMAN","sp|Q5TCQ9|MAGI3_HUMAN",2741,"Q5TCQ9","MAGI3_HUMAN","Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3",null,"MAGI3"]
["15.0591","16.407",1,1,{"$nulls":3},"cellular glucuronidation;flavonoid glucuronidation;metabolic process;negative regulation of cellular glucuronidation;negative regulation of fatty acid metabolic process;negative regulation of glucuronosyltransferase activity;retinoic acid metabolic process;xenobiotic glucuronidation","enzyme binding;glucuronosyltransferase activity;protein heterodimerization activity;protein homodimerization activity;retinoic acid binding","endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane","Ascorbate and aldarate metabolism;Chemical carcinogenesis;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Metabolism of xenobiotics by cytochrome P450;Pentose and glucuronate interconversions;Porphyrin and chlorophyll metabolism;Retinol metabolism;Steroid hormone biosynthesis",null,null,8,2,2,"24.7","4.7","4.7","60.338","0.00023935","5.4263",35396000,4,"2.68071",1,"14.733","21.8613","sp|P35503|UD13_HUMAN","sp|P35503|UD13_HUMAN",1385,"P35503","UD13_HUMAN","UDP-glucuronosyltransferase 1-3","DPGT 1-3;GT1*3;GT1.3;GT1-03","UGT1A3"]
["15.0855","15.8462",1,1,{"$nulls":3},"endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)","RNA binding","90S preribosome;nucleolus",{"$nulls":3},8,8,8,"17.5","17.5","17.5","82.597",0,"56.327",167870000,40,"3.16071",1,"14.4658","38.0304","sp|Q8N9T8|KRI1_HUMAN;tr|H0YFD2|H0YFD2_HUMAN;tr|F8WFC1|F8WFC1_HUMAN;tr|H0YH26|H0YH26_HUMAN","sp|Q8N9T8|KRI1_HUMAN",3271,"Q8N9T8","KRI1_HUMAN","Protein KRI1 homolog",null,"KRI1"]
["15.099","15.3616",1,1,{"$nulls":3},"cytoskeleton-dependent intracellular transport;microtubule-based movement;retrograde vesicle-mediated transport, Golgi to ER","ATP binding;ATPase activity;microtubule binding;microtubule motor activity;motor activity;RNA binding","endoplasmic reticulum;Golgi apparatus;kinesin complex;microtubule",{"$nulls":3},4,2,2,"5.7","3.4","3.4","122.95","0.0054119","2.6697",12388000,3,"4.06988",1,"14.2303","108.371","sp|O43896|KIF1C_HUMAN","sp|O43896|KIF1C_HUMAN",449,"O43896","KIF1C_HUMAN","Kinesin-like protein KIF1C",null,"KIF1C"]
["15.1149","15.3291",1,1,{"$nulls":3},"cellular response to UV;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of protein ubiquitination",null,"nucleolus;PML body",{"$nulls":3},1,1,1,"1.8","1.8","1.8","100.38","0.0036991","2.9842",11271000,3,"4.24663",1,"14.222","132.83","sp|O75113|N4BP1_HUMAN","sp|O75113|N4BP1_HUMAN",522,"O75113","N4BP1_HUMAN","NEDD4-binding protein 1","4BP1","N4BP1"]
["14.6389","15.2473",1,1,{"$nulls":4},"metal ion binding;metalloendopeptidase activity",{"$nulls":4},4,4,4,"4.7","4.7","4.7","125.12","0.0037159","3.0757",13161000,3,"3.32283",1,"13.9431","45.8417","tr|G3V1R5|G3V1R5_HUMAN;sp|O43847|NRDC_HUMAN;tr|B1AKJ5|B1AKJ5_HUMAN;tr|H0Y5G9|H0Y5G9_HUMAN;tr|A0A087WYK8|A0A087WYK8_HUMAN;tr|F5H7V1|F5H7V1_HUMAN","tr|G3V1R5|G3V1R5_HUMAN;sp|O43847|NRDC_HUMAN;tr|B1AKJ5|B1AKJ5_HUMAN;tr|H0Y5G9|H0Y5G9_HUMAN;tr|A0A087WYK8|A0A087WYK8_HUMAN;tr|F5H7V1|F5H7V1_HUMAN",446,"G3V1R5","G3V1R5_HUMAN",null,null,"NRDC"]
["13.5111","15.7033",1,1,{"$nulls":4},"nucleic acid binding","cytosol;nucleoplasm;plasma membrane",{"$nulls":3},5,5,5,"5.8","5.8","5.8","145.44",0,"10.9",51204000,11,"2.19205",1,"13.6072","12.4144","tr|S4R3H4|S4R3H4_HUMAN;tr|E7EQT4|E7EQT4_HUMAN;sp|Q9UKV3|ACINU_HUMAN;tr|G3V3B0|G3V3B0_HUMAN;tr|G3V3T3|G3V3T3_HUMAN","tr|S4R3H4|S4R3H4_HUMAN;tr|E7EQT4|E7EQT4_HUMAN;sp|Q9UKV3|ACINU_HUMAN;tr|G3V3B0|G3V3B0_HUMAN",5306,"S4R3H4","S4R3H4_HUMAN",null,null,"ACIN1"]
["12.6145","14.162",1,1,{"$nulls":3},"activation of protein kinase activity;cell division;cell proliferation in forebrain;cerebellar cortex development;cerebellar granular layer structural organization;cerebellar Purkinje cell layer structural organization;cerebral cortex development;establishment of protein localization;hippocampus development;microtubule-based movement;mitotic metaphase plate congression;negative regulation of apoptotic process;negative regulation of integrin activation;negative regulation of neuron apoptotic process;olfactory bulb development;positive regulation of cell proliferation;positive regulation of cytokinesis;proteasome-mediated ubiquitin-dependent protein catabolic process;regulation of cell adhesion;regulation of cell growth;regulation of cell maturation;regulation of cell migration;regulation of G1/S transition of mitotic cell cycle;regulation of G2/M transition of mitotic cell cycle;regulation of myelination;regulation of neuron apoptotic process;regulation of Rap protein signal transduction;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;substrate adhesion-dependent cell spreading","ATP binding;ATPase activity;ATP-dependent microtubule motor activity, plus-end-directed;microtubule binding;microtubule motor activity;PDZ domain binding;protein kinase binding;tubulin binding","cytosol;kinesin complex;membrane;microtubule;midbody;nucleus;spindle midzone",{"$nulls":3},6,6,6,"4.7","4.7","4.7","186.49",0,"9.0421",45599000,10,"2.41138",1,"12.3883","16.0112","sp|Q15058|KIF14_HUMAN","sp|Q15058|KIF14_HUMAN",2443,"Q15058","KIF14_HUMAN","Kinesin-like protein KIF14 {ECO:0000305}",null,"KIF14"]
["16.0643","15.952","14.2412","14.2561",{"$nulls":3},"mRNA 3'-end processing;mRNA export from nucleus;poly(A)+ mRNA export from nucleus;RNA export from nucleus;termination of RNA polymerase II transcription","metal ion binding;RNA binding","nucleoplasm",{"$nulls":3},4,4,4,"8.1","8.1","8.1","89.13",0,"25.651",78527000,30,"2.98532",1,"1.75948","31.0689","sp|O75152|ZC11A_HUMAN;tr|E9PQ61|E9PQ61_HUMAN;tr|E9PBY7|E9PBY7_HUMAN","sp|O75152|ZC11A_HUMAN;tr|E9PQ61|E9PQ61_HUMAN",530,"O75152","ZC11A_HUMAN","Zinc finger CCCH domain-containing protein 11A",null,"ZC3H11A"]
["16.3277","16.5988","14.5688","15.0662",{"$nulls":3},"negative regulation of protein localization to nucleolus;positive regulation of gene expression, epigenetic;termination of RNA polymerase I transcription;transcription elongation from RNA polymerase I promoter;transcription initiation from RNA polymerase I promoter","chromatin binding;DNA binding;RNA polymerase I activity;zinc ion binding","DNA-directed RNA polymerase I complex;nucleoplasm","RNA polymerase",null,null,34,34,33,"26.5","26.5","25.9","194.81",0,"123.73",1228900000,151,"1.54713",1,"1.64572","5.8099","sp|O95602|RPA1_HUMAN;tr|B9ZVN9|B9ZVN9_HUMAN","sp|O95602|RPA1_HUMAN;tr|B9ZVN9|B9ZVN9_HUMAN",746,"O95602","RPA1_HUMAN","DNA-directed RNA polymerase I subunit RPA1","NA polymerase I subunit A1","POLR1A"]
["16.0958","15.9456","14.6755","14.885",{"$nulls":3},"animal organ development;apoptotic process;establishment of mitotic spindle orientation;Golgi organization;negative regulation of extrinsic apoptotic signaling pathway;positive regulation of aggrephagy;positive regulation of apoptotic process;positive regulation of autophagy of mitochondrion;positive regulation of cilium assembly;positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;positive regulation of lipophagy;protein destabilization;regulation of phosphoprotein phosphatase activity;retrograde vesicle-mediated transport, Golgi to ER;vesicle transport along microtubule;vocal learning","beta-tubulin binding;dynactin binding;dynein intermediate chain binding;heat shock protein binding;identical protein binding;ion channel binding;kinase binding;lipid transporter activity;p53 binding;profilin binding;transcription factor binding","autophagosome;axon;centriole;cytoplasm;cytoplasmic vesicle membrane;cytosol;dendrite;endoplasmic reticulum;Golgi apparatus;inclusion body;late endosome;nucleoplasm;nucleus;perinuclear region of cytoplasm;protein complex","Huntington disease",null,null,9,9,9,4,4,4,"347.6",0,"19.931",62838000,12,"1.97356",1,"1.2404","9.62269","sp|P42858|HD_HUMAN","sp|P42858|HD_HUMAN",1482,"P42858","HD_HUMAN","Huntingtin",null,"HTT"]
["18.1927","18.0154","17.1291","16.6809",{"$nulls":3},"NAD biosynthesis via nicotinamide riboside salvage pathway","ADP-dependent NAD(P)H-hydrate dehydratase activity;ATP binding;ATP-dependent NAD(P)H-hydrate dehydratase activity","mitochondrial matrix",{"$nulls":3},2,2,2,"10.4","10.4","10.4","36.576","0.00087873","3.9219",33460000,3,"1.41904",1,"1.19908","4.97537","sp|Q8IW45|NNRD_HUMAN","sp|Q8IW45|NNRD_HUMAN",3121,"Q8IW45","NNRD_HUMAN","ATP-dependent (S)-NAD(P)H-hydrate dehydratase {ECO:0000255|HAMAP-Rule:MF_03157}",null,"NAXD"]
["17.2437","17.5578","16.1696","16.4206",{"$nulls":3},"adherens junction organization;axonogenesis;lateral ventricle development;negative regulation of protein localization to plasma membrane;neuroblast division in subventricular zone;positive regulation of cell migration;positive regulation of neurogenesis","alpha-catenin binding;beta-catenin binding;cadherin binding","apical part of cell;basolateral plasma membrane;clathrin-coated vesicle;early endosome;extrinsic component of plasma membrane;focal adhesion;nucleus;plasma membrane","Notch signaling pathway",null,null,17,17,17,"47.6","47.6","47.6","70.803",0,"70.864",555160000,85,"1.50167",1,"1.10564","5.50024","sp|P49757|NUMB_HUMAN;tr|G3V3Z8|G3V3Z8_HUMAN;tr|G3V3R1|G3V3R1_HUMAN;tr|G3V3M5|G3V3M5_HUMAN;tr|G3V4S6|G3V4S6_HUMAN;tr|G3V433|G3V433_HUMAN","sp|P49757|NUMB_HUMAN;tr|G3V3Z8|G3V3Z8_HUMAN",1597,"P49757","NUMB_HUMAN","Protein numb homolog",{"$error":"#NAME?"},"NUMB"]
[]
["14.1524","14.0741","15.5535","15.1572",{"$nulls":3},"chondrocyte differentiation involved in endochondral bone morphogenesis;Golgi organization;inner ear receptor stereocilium organization;intraciliary transport involved in cilium assembly;protein glycosylation;transcription from RNA polymerase II promoter;ventricular septum development","transcription coactivator activity","cilium;cis-Golgi network;cytoskeleton;Golgi apparatus;Golgi membrane;inner acrosomal membrane;nuclear speck;nucleus;outer acrosomal membrane;transport vesicle",{"$nulls":3},4,4,4,"2.7","2.7","2.7","227.58",0,"13.433",43198000,12,"1.59449",1,"-1.24209","-6.14939","sp|Q15643|TRIPB_HUMAN;tr|H0YJ97|H0YJ97_HUMAN","sp|Q15643|TRIPB_HUMAN;tr|H0YJ97|H0YJ97_HUMAN",2507,"Q15643","TRIPB_HUMAN","Thyroid receptor-interacting protein 11","R-interacting protein 11;RIP-11","TRIP11"]
["17.7688","18.027","19.2994","18.9956",{"$nulls":3},"cell-cell signaling;transmembrane receptor protein tyrosine kinase signaling pathway","structural molecule activity","cell surface;focal adhesion;integral component of plasma membrane","Cell adhesion molecules (CAMs)",null,null,3,3,3,"14.1","14.1","14.1","29.082","0.00023878","5.3985",45839000,8,"1.61044",1,"-1.24961","-6.26783","sp|O95297|MPZL1_HUMAN;tr|Q9UEL6|Q9UEL6_HUMAN","sp|O95297|MPZL1_HUMAN",712,"O95297","MPZL1_HUMAN","Myelin protein zero-like protein 1",null,"MPZL1"]
["17.1444","16.8756","18.3726","18.2323",{"$nulls":3},"platelet degranulation","ATP binding","extracellular region;integral component of membrane;platelet alpha granule lumen",{"$nulls":3},11,11,11,"30.5","30.5","30.5","46.914",0,"24.288",386200000,48,"1.87023",1,"-1.29248","-8.52487","sp|Q9NXH8|TOR4A_HUMAN","sp|Q9NXH8|TOR4A_HUMAN",4547,"Q9NXH8","TOR4A_HUMAN","Torsin-4A",null,"TOR4A"]
["14.0753","14.5582","15.7404","16.0991",{"$nulls":3},"intracellular signal transduction","actin binding;ATP binding;GTPase activator activity;motor activity","cytosol;myosin complex",{"$nulls":3},39,39,38,"22.5","22.5","22.2","234.07",0,"129.72",847970000,110,"1.47564",1,"-1.60303","-5.32976","tr|M0R300|M0R300_HUMAN;tr|M0R0P8|M0R0P8_HUMAN;sp|Q13459|MYO9B_HUMAN;tr|M0QZY4|M0QZY4_HUMAN;tr|M0R332|M0R332_HUMAN;tr|M0QXP0|M0QXP0_HUMAN","tr|M0R300|M0R300_HUMAN;tr|M0R0P8|M0R0P8_HUMAN;sp|Q13459|MYO9B_HUMAN",2261,"M0R300","M0R300_HUMAN",null,null,"MYO9B"]
["16.9765","16.2867","18.6705","18.4429",{"$nulls":3},"ossification;positive regulation of interferon-alpha secretion;positive regulation of telomere maintenance;positive regulation of transcription from RNA polymerase II promoter;positive regulation of type I interferon production;response to exogenous dsRNA;response to virus;RNA processing;RNA secondary structure unwinding;telomerase RNA stabilization;transcription, DNA-templated","ATP binding;ATP-dependent RNA helicase activity;core promoter binding;DNA-dependent ATPase activity;double-stranded RNA binding;G-quadruplex DNA binding;G-quadruplex RNA binding;histone deacetylase binding;RNA binding;single-stranded DNA binding;telomerase RNA binding;transcription regulatory region DNA binding","chromosome, telomeric region;cytoplasm;cytosol;extracellular exosome;nucleus","RNA degradation",null,null,8,8,8,"11.8","11.8","11.8","114.76",0,"16.686",139510000,9,"1.47116",1,"-1.92513","-5.30091","sp|Q9H2U1|DHX36_HUMAN;tr|E7EWK3|E7EWK3_HUMAN;tr|A0A0G2JRP3|A0A0G2JRP3_HUMAN;tr|H7C5F5|H7C5F5_HUMAN;tr|A0A0G2JQU7|A0A0G2JQU7_HUMAN","sp|Q9H2U1|DHX36_HUMAN;tr|E7EWK3|E7EWK3_HUMAN",4176,"Q9H2U1","DHX36_HUMAN","ATP-dependent RNA helicase DHX36",null,"DHX36"]
["17.4884","17.2192","19.9499","19.5609",{"$nulls":3},"apoptotic chromosome condensation;cellular response to DNA damage stimulus;chromosome segregation;DNA ligation;DNA topological change;embryonic cleavage;hematopoietic progenitor cell differentiation;mitotic DNA integrity checkpoint;negative regulation of DNA duplex unwinding;positive regulation of apoptotic process;positive regulation of single stranded viral RNA replication via double stranded DNA intermediate;positive regulation of transcription from RNA polymerase II promoter;positive regulation of viral genome replication;protein sumoylation;regulation of circadian rhythm;resolution of meiotic recombination intermediates;rhythmic process;sister chromatid segregation","ATP binding;chromatin binding;DNA binding;DNA binding, bending;DNA topoisomerase type II (ATP-hydrolyzing) activity;DNA-dependent ATPase activity;drug binding;enzyme binding;histone deacetylase binding;magnesium ion binding;protein C-terminus binding;protein heterodimerization activity;protein homodimerization activity;protein kinase C binding;RNA binding;ubiquitin binding","condensed chromosome;cytoplasm;DNA topoisomerase complex (ATP-hydrolyzing);intracellular ribonucleoprotein complex;nucleolus;nucleoplasm;nucleus;protein complex","Platinum drug resistance",null,null,50,36,36,38,"29.7","29.7","174.38",0,"251.71",2058700000,195,"2.01941",1,"-2.40159","-10.1525","sp|P11388|TOP2A_HUMAN;tr|J3KTB7|J3KTB7_HUMAN","sp|P11388|TOP2A_HUMAN",996,"P11388","TOP2A_HUMAN","DNA topoisomerase 2-alpha",null,"TOP2A"]
["13.4307","13.8895","16.3982","16.1615",{"$nulls":4},"calcium ion binding",{"$nulls":4},5,5,5,5,5,5,"130.01","0.00025793","7.033",29857000,4,"2.01912",1,"-2.61972","-10.1491","tr|F8W7U0|F8W7U0_HUMAN;sp|Q15811|ITSN1_HUMAN;tr|A8CTZ0|A8CTZ0_HUMAN;CON__ENSEMBL:ENSBTAP00000001528;tr|H7C429|H7C429_HUMAN;tr|C9JXS9|C9JXS9_HUMAN;tr|C9J1A4|C9J1A4_HUMAN;tr|H0Y523|H0Y523_HUMAN;tr|C9JQZ7|C9JQZ7_HUMAN","tr|F8W7U0|F8W7U0_HUMAN;sp|Q15811|ITSN1_HUMAN;tr|A8CTZ0|A8CTZ0_HUMAN",2524,"F8W7U0","F8W7U0_HUMAN",null,null,"ITSN1"]
[1,1,"13.7502","13.8112",{"$nulls":4},"chromatin binding","cytosol;mitochondrion;nuclear membrane;nucleus",{"$nulls":3},5,5,5,"2.6","2.6","2.6","314.46","0.00025767","7.0243",67700000,5,"5.24464",1,"-12.7807","-419.099","tr|H9KVB4|H9KVB4_HUMAN;sp|O15417|TNC18_HUMAN;tr|H7C0N9|H7C0N9_HUMAN","tr|H9KVB4|H9KVB4_HUMAN;sp|O15417|TNC18_HUMAN",363,"H9KVB4","H9KVB4_HUMAN",null,null,"TNRC18"]
[1,1,"13.6911","15.5546",{"$nulls":3},"chromosome separation;female meiosis chromosome segregation;meiotic spindle assembly checkpoint;mitotic spindle assembly checkpoint;mitotic spindle organization;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of cell proliferation;positive regulation of pathway-restricted SMAD protein phosphorylation;protein autophosphorylation;protein localization to kinetochore;protein localization to meiotic spindle midzone;spindle organization","ATP binding;protein homodimerization activity;protein serine/threonine kinase activity;protein serine/threonine/tyrosine kinase activity;protein tyrosine kinase activity","cytoplasm;kinetochore;membrane;spindle","Cell cycle",null,null,8,8,8,"15.5","15.5","15.5","97.071",0,"19.63",154050000,19,"2.33298",1,"-13.6228","-14.6209","sp|P33981|TTK_HUMAN;tr|D6RF82|D6RF82_HUMAN;tr|D6REX1|D6REX1_HUMAN;tr|D6RIC6|D6RIC6_HUMAN","sp|P33981|TTK_HUMAN",1360,"P33981","TTK_HUMAN","Dual specificity protein kinase TTK",null,"TTK"]
[1,1,"15.2979","14.9874",{"$nulls":3},"cation transport;cellular response to heat;chloride transmembrane transport;chloride transport;detection of temperature stimulus involved in sensory perception of pain;iodide transport;ion transmembrane transport;multicellular organism development;phospholipase C-activating G-protein coupled receptor signaling pathway;positive regulation of insulin secretion involved in cellular response to glucose stimulus","calcium activated cation channel activity;chloride channel activity;intracellular calcium activated chloride channel activity;iodide transmembrane transporter activity;protein dimerization activity;voltage-gated chloride channel activity","apical plasma membrane;chloride channel complex;cytoplasm;extracellular exosome;plasma membrane",{"$nulls":3},8,8,8,"6.7","6.7","6.7","114.08",0,"10.625",126860000,11,"3.91889",1,"-14.1426","-91.0763","sp|Q5XXA6|ANO1_HUMAN;tr|E9PP68|E9PP68_HUMAN;tr|H0YDD9|H0YDD9_HUMAN;tr|E9PNA7|E9PNA7_HUMAN;tr|E9PS90|E9PS90_HUMAN","sp|Q5XXA6|ANO1_HUMAN;tr|E9PP68|E9PP68_HUMAN;tr|H0YDD9|H0YDD9_HUMAN",2777,"Q5XXA6","ANO1_HUMAN","Anoctamin-1",null,"ANO1"]
[1,1,"14.8811","15.4392",{"$nulls":9},2,2,2,"1.3","1.3","1.3","237.3","0.0006643","4.0461",215350000,11,"3.41103",1,"-14.1602","-50.7442","sp|Q5THK1|PR14L_HUMAN;tr|C9J9V0|C9J9V0_HUMAN;tr|H7C1B0|H7C1B0_HUMAN;tr|H3BLU3|H3BLU3_HUMAN;sp|Q9BWN1|PRR14_HUMAN","sp|Q5THK1|PR14L_HUMAN;tr|C9J9V0|C9J9V0_HUMAN;tr|H7C1B0|H7C1B0_HUMAN;tr|H3BLU3|H3BLU3_HUMAN;sp|Q9BWN1|PRR14_HUMAN",2747,"Q5THK1","PR14L_HUMAN","Protein PRR14L",null,"PRR14L"]
[1,1,"15.2558","15.4471",{"$nulls":3},"cell cycle;cellular response to ATP;cellular response to DNA damage stimulus;cellular response to UV;DNA-templated transcription, initiation;midbrain development;negative regulation of gene expression;negative regulation of protein autoubiquitination;negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding;peptidyl-serine phosphorylation;peptidyl-threonine phosphorylation;positive regulation of androgen receptor activity;positive regulation of cell proliferation;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of protein binding;positive regulation of transcription from RNA polymerase I promoter;positive regulation of transcription from RNA polymerase II promoter;positive regulation of transcription initiation from RNA polymerase II promoter;protein autophosphorylation;protein phosphorylation;protein polyubiquitination;protein stabilization;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of cell cycle G1/S phase transition;regulation of signal transduction by p53 class mediator;regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage;regulation of transcription initiation from RNA polymerase II promoter;RNA polymerase II transcriptional preinitiation complex assembly;transcription elongation from RNA polymerase II promoter;transcription factor catabolic process;transcription from RNA polymerase II promoter;transcription initiation from RNA polymerase II promoter;viral process","ATP binding;histone acetyltransferase activity;kinase activity;lysine-acetylated histone binding;p53 binding;protein heterodimerization activity;protein serine/threonine kinase activity;RNA polymerase II core promoter sequence-specific DNA binding;RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly;sequence-specific DNA binding;TBP-class protein binding;transcription coactivator activity;transcription factor binding;ubiquitin conjugating enzyme activity","MLL1 complex;nuclear chromatin;nucleoplasm;nucleus;transcription factor complex;transcription factor TFIID complex","Basal transcription factors",null,null,14,14,6,"11.3","11.3","4.6","212.67",0,"43.093",335250000,55,"4.35286",1,"-14.3514","-150.111","sp|P21675|TAF1_HUMAN;tr|H7BY98|H7BY98_HUMAN;tr|H7C2K9|H7C2K9_HUMAN;tr|H0Y9L7|H0Y9L7_HUMAN","sp|P21675|TAF1_HUMAN",1167,"P21675","TAF1_HUMAN","Transcription initiation factor TFIID subunit 1",null,"TAF1"]
[1,1,"15.8264","15.8635",{"$nulls":3},"actin filament organization;negative regulation of small GTPase mediated signal transduction","motor activity","bicellular tight junction;myosin complex","Tight junction",null,null,2,2,2,"1.8","1.8","1.8","149.08","0.0090559","2.2554",18223000,3,"5.80741",1,"-14.845","-801.136","sp|Q0VF96|CGNL1_HUMAN","sp|Q0VF96|CGNL1_HUMAN",2146,"Q0VF96","CGNL1_HUMAN","Cingulin-like protein 1",null,"CGNL1"]
[1,1,"16.2211","16.3152",{"$nulls":3},"negative regulation of transmembrane transport;negative regulation of transporter activity;protein dephosphorylation","protein phosphatase 2A binding","actin cytoskeleton;cytoplasm",{"$nulls":3},2,2,2,"6.6","6.6","6.6","70.157","0.0037244","3.0981",49557000,4,"5.02238",1,"-15.2681","-324.479","sp|Q9P2B4|CT2NL_HUMAN","sp|Q9P2B4|CT2NL_HUMAN",4638,"Q9P2B4","CT2NL_HUMAN","CTTNBP2 N-terminal-like protein",null,"CTTNBP2NL"]
[1,1,"15.9386","17.1153",{"$nulls":4},"zinc ion binding","nucleoplasm",{"$nulls":3},4,4,3,"10.6","10.6","7.8","50.403",0,"8.4553",67203000,4,"2.84381",1,"-15.527","-26.3899","tr|B3KPJ4|B3KPJ4_HUMAN;tr|A0A0A0MSI2|A0A0A0MSI2_HUMAN;sp|Q8IXK0|PHC2_HUMAN","tr|B3KPJ4|B3KPJ4_HUMAN;tr|A0A0A0MSI2|A0A0A0MSI2_HUMAN;sp|Q8IXK0|PHC2_HUMAN",3147,"B3KPJ4","B3KPJ4_HUMAN",null,null,"PHC2"]
[1,1,"16.6392","16.9374",{"$nulls":3},"histone H3-K4 methylation",null,"Set1C/COMPASS complex",{"$nulls":3},1,1,1,"3.9","3.9","3.9","55.324","0.00066269","3.9991",49469000,5,"4.04965",1,"-15.7883","-105.876","tr|F5H8F7|F5H8F7_HUMAN;sp|Q9UBL3|ASH2L_HUMAN","tr|F5H8F7|F5H8F7_HUMAN;sp|Q9UBL3|ASH2L_HUMAN",4665,"F5H8F7","F5H8F7_HUMAN",null,null,"ASH2L"]
[1,1,"16.5096","17.3986",{"$nulls":3},"negative regulation of phosphatase activity","phosphatase binding","cytosol",{"$nulls":3},1,1,1,"2.6","2.6","2.6","52.726","0.004881","2.859",10423000,2,"3.1105",1,"-15.9541","-35.8921","sp|Q9H788|SH24A_HUMAN","sp|Q9H788|SH24A_HUMAN",4238,"Q9H788","SH24A_HUMAN","SH2 domain-containing protein 4A",null,"SH2D4A"]
[1,1,"17.2085","17.981",{"$nulls":3},"intracellular signal transduction;Wnt signaling pathway",null,"aggresome;nuclear body;nucleoplasm",{"$nulls":3},3,3,3,"5.6","5.6","5.6","78.375","0.00025753","7.0218",43727000,5,"3.26656",1,"-16.5947","-42.9641","tr|I3L2N2|I3L2N2_HUMAN;sp|O14641|DVL2_HUMAN;tr|I3L2W9|I3L2W9_HUMAN;tr|I3L0Z8|I3L0Z8_HUMAN","tr|I3L2N2|I3L2N2_HUMAN;sp|O14641|DVL2_HUMAN;tr|I3L2W9|I3L2W9_HUMAN",269,"I3L2N2","I3L2N2_HUMAN",null,null,"DVL2"]
[1,1,"17.3632","17.9644",{"$nulls":3},"cellular hyperosmotic response;cellular response to glucose starvation;cellular response to mechanical stimulus;cerebral cortex development;female pregnancy;glucose transmembrane transport;glucose transport;lactose biosynthetic process;L-ascorbic acid metabolic process;protein complex assembly;regulation of glucose transport;regulation of insulin secretion;response to insulin;response to Thyroglobulin triiodothyronine","dehydroascorbic acid transmembrane transporter activity;D-glucose transmembrane transporter activity;glucose transmembrane transporter activity;identical protein binding;kinase binding;protein self-association;xenobiotic transmembrane transporter activity","apical plasma membrane;basolateral plasma membrane;blood microparticle;caveola;cortical actin cytoskeleton;cytosol;extracellular exosome;female pronucleus;Golgi membrane;integral component of plasma membrane;intercalated disc;melanosome;membrane;midbody;plasma membrane;sarcolemma;Z disc","Adipocytokine signaling pathway;Bile secretion;Central carbon metabolism in cancer;Glucagon signaling pathway;HIF-1 signaling pathway;Human T-cell leukemia virus 1 infection;Insulin resistance;Insulin secretion;Pathways in cancer;Renal cell carcinoma;Thyroid hormone signaling pathway",null,null,2,2,2,"5.1","5.1","5.1","54.083","0.00087893","3.9267",13571000,2,"3.4878",1,"-16.6638","-55.4365","sp|P11166|GTR1_HUMAN","sp|P11166|GTR1_HUMAN",984,"P11166","GTR1_HUMAN","Solute carrier family 2, facilitated glucose transporter member 1",null,"SLC2A1"]
[1,1,"17.548","17.8671",{"$nulls":3},"base-excision repair","catalytic activity;DNA binding",{"$nulls":4},1,1,1,"7.8","7.8","7.8","23.717","0.0023212","3.3581",12980000,2,"4.04011",1,"-16.7076","-104.718","tr|H3BRL9|H3BRL9_HUMAN;sp|P78549|NTH_HUMAN","tr|H3BRL9|H3BRL9_HUMAN;sp|P78549|NTH_HUMAN",1983,"H3BRL9","H3BRL9_HUMAN",null,null,"NTHL1"]
[1,1,"18.2713","17.534",{"$nulls":3},"nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;rRNA processing;SRP-dependent cotranslational protein targeting to membrane;translation;translational initiation;viral transcription","metal ion binding;RNA binding;rRNA binding;structural constituent of ribosome","cytosol;cytosolic large ribosomal subunit","Ribosome",null,null,2,2,2,"17.5","17.5","17.5","11.078","0.0015009","3.5444",49955000,10,"3.3231",1,"-16.9026","-45.8558","sp|P61927|RL37_HUMAN;tr|D6RG19|D6RG19_HUMAN","sp|P61927|RL37_HUMAN;tr|D6RG19|D6RG19_HUMAN",1859,"P61927","RL37_HUMAN","60S ribosomal protein L37",null,"RPL37"]
[1,1,"18.9579","17.1951",{"$nulls":3},"ribosomal large subunit biogenesis","RNA binding","intracellular membrane-bounded organelle;nucleolus;nucleus",{"$nulls":3},9,9,9,"50.6","50.6","50.6","21.188",0,"36.431",563520000,77,"2.57619",1,"-17.0765","-19.3744","sp|Q9Y3C1|NOP16_HUMAN;tr|D6RIC3|D6RIC3_HUMAN;tr|A0A0C4DGU5|A0A0C4DGU5_HUMAN;tr|A0A087X2G6|A0A087X2G6_HUMAN;tr|A0A087X1T1|A0A087X1T1_HUMAN;tr|D6RC60|D6RC60_HUMAN;tr|A0A087WU10|A0A087WU10_HUMAN","sp|Q9Y3C1|NOP16_HUMAN;tr|D6RIC3|D6RIC3_HUMAN;tr|A0A0C4DGU5|A0A0C4DGU5_HUMAN;tr|A0A087X2G6|A0A087X2G6_HUMAN;tr|A0A087X1T1|A0A087X1T1_HUMAN",4978,"Q9Y3C1","NOP16_HUMAN","Nucleolar protein 16",null,"NOP16"]
[1,1,"18.1188","19.6573",{"$nulls":3},"mitochondrial electron transport, NADH to ubiquinone;mitochondrial respiratory chain complex I assembly","NADH dehydrogenase (ubiquinone) activity","mitochondrial inner membrane;mitochondrial intermembrane space;mitochondrial respiratory chain complex I;mitochondrion","Alzheimer disease;Huntington disease;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Oxidative phosphorylation;Parkinson disease;Retrograde endocannabinoid signaling;Thermogenesis",null,null,2,2,2,"18.2","18.2","18.2","16.402","0.00023992","5.4976",10157000,3,"2.7342",1,"-17.8881","-23.2541","sp|P17568|NDUB7_HUMAN","sp|P17568|NDUB7_HUMAN",1101,"P17568","NDUB7_HUMAN","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7",null,"NDUFB7"]
[1,1,"19.3172","18.6729",{"$nulls":3},"one-carbon metabolic process;phosphatidylinositol-mediated signaling","carbonate dehydratase activity;zinc ion binding","cytoplasm","Metabolic pathways;Nitrogen metabolism",null,null,2,2,2,11,11,11,"32.973","0.00025517","6.8187",31542000,5,"3.49444",1,"-17.9951","-55.8616","sp|P35219|CAH8_HUMAN","sp|P35219|CAH8_HUMAN",1370,"P35219","CAH8_HUMAN","Carbonic anhydrase-related protein","ARP","CA8"]
[1,1,"19.0832","19.3124",{"$nulls":4},"GTP binding",{"$nulls":4},5,5,5,"30.9","30.9","30.9","26.422",0,"9.3518",117790000,14,"4.4019",1,"-18.1978","-158.832","sp|Q5HYI8|RABL3_HUMAN;tr|C9JXM3|C9JXM3_HUMAN;tr|F8WF50|F8WF50_HUMAN;tr|F8WDC7|F8WDC7_HUMAN;tr|H7C533|H7C533_HUMAN;tr|F8WAX9|F8WAX9_HUMAN","sp|Q5HYI8|RABL3_HUMAN;tr|C9JXM3|C9JXM3_HUMAN",2689,"Q5HYI8","RABL3_HUMAN","Rab-like protein 3",null,"RABL3"]
[1,1,"19.9049","18.6078",{"$nulls":3},"proteasome assembly",{"$nulls":5},1,1,1,"23.1","23.1","23.1","11.655","0.00046838","4.9495",29255000,7,"2.89973",1,"-18.2563","-28.1485","tr|D6RB92|D6RB92_HUMAN;sp|Q5JS54|PSMG4_HUMAN","tr|D6RB92|D6RB92_HUMAN;sp|Q5JS54|PSMG4_HUMAN",2696,"D6RB92","D6RB92_HUMAN",null,null,"PSMG4"]
[1,1,"18.7576","19.9066",{"$nulls":9},2,2,2,"21.1","21.1","21.1","13.148","0.0002471","6.1509",23881000,5,"3.00848",1,"-18.3321","-31.9095","tr|M0R2P8|M0R2P8_HUMAN;tr|M0R3A4|M0R3A4_HUMAN;tr|M0QYA2|M0QYA2_HUMAN;sp|Q9NWS0|PIHD1_HUMAN;tr|M0QYF4|M0QYF4_HUMAN;tr|M0QXD5|M0QXD5_HUMAN","tr|M0R2P8|M0R2P8_HUMAN;tr|M0R3A4|M0R3A4_HUMAN;tr|M0QYA2|M0QYA2_HUMAN;sp|Q9NWS0|PIHD1_HUMAN;tr|M0QYF4|M0QYF4_HUMAN;tr|M0QXD5|M0QXD5_HUMAN",4516,"M0R2P8","M0R2P8_HUMAN",null,null,"PIH1D1"]
[1,1,"18.2896","20.5724",{"$nulls":3},"mRNA transport;negative regulation of vascular endothelial growth factor production;positive regulation of protein import into nucleus;protein export from nucleus;protein import into nucleus;protein import into nucleus, translocation;protein localization to nuclear pore","identical protein binding;nucleocytoplasmic transporter activity;protein transporter activity;Ran GTPase binding","cytosol;extracellular exosome;nuclear inner membrane;nuclear membrane;nuclear outer membrane;nuclear pore central transport channel;nucleoplasm",{"$nulls":3},2,2,2,"17.3","17.3","17.3","14.478","0.00069109","4.6529",17361000,2,"2.41872",1,"-18.431","-16.1479","sp|P61970|NTF2_HUMAN;tr|H3BRV9|H3BRV9_HUMAN","sp|P61970|NTF2_HUMAN;tr|H3BRV9|H3BRV9_HUMAN",1865,"P61970","NTF2_HUMAN","Nuclear transport factor 2 {ECO:0000303|PubMed:7744965}","TF-2","NUTF2"]
[1,1,"20.1302","21.0102",{"$nulls":9},1,1,1,"64.3","64.3","64.3","2.9523","0.0015138","3.6755",15381000,4,"3.29656",1,"-19.5702","-44.4748","tr|F8W6F4|F8W6F4_HUMAN;tr|B1AHC2|B1AHC2_HUMAN;tr|B1AHF8|B1AHF8_HUMAN;tr|F8WCV8|F8WCV8_HUMAN;sp|P85298|RHG08_HUMAN","tr|F8W6F4|F8W6F4_HUMAN;tr|B1AHC2|B1AHC2_HUMAN;tr|B1AHF8|B1AHF8_HUMAN;tr|F8WCV8|F8WCV8_HUMAN;sp|P85298|RHG08_HUMAN",2016,"F8W6F4","F8W6F4_HUMAN",null,null,"ARHGAP8"]