{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["Supplementary material 8A ","Supplementary material 8B","Supplementary material 8C","Supplementary material 8D"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supplementary material 8A ","index":0,"n_rows":42,"n_cols":7,"rows_kept":42,"merged":[[0,0,0,11]],"flags":["formulas_cached_only"]}
["Supplementary material 8A  Total set of the top 20 KEGG enrichment pathways for differentially expressed mRNAs in MM_F_P vs MM_L_P. "]
["pathway_term","rich_factor","qvalue","gene_number","Pvalue","-Log10(Pvalue)","regulation"]
["Protein processing in endoplasmic reticulum",0.0625,0.156706045924,11,0.00126881320174,2.8966023112583397,"up"]
["Carbon metabolism",0.073394495412844,0.156706045924,8,0.00225566224468,2.646725929623643,"up"]
["RNA transport",0.0598802395209581,0.156706045924,10,0.00278842016887,2.5546417846368397,"up"]
["Butanoate metabolism",0.142857142857143,0.156706045924,4,0.003463117037,2.4605328311001533,"up"]
["Legionellosis",0.08,0.192358703741,6,0.00531377634644,2.2745967287272166,"up"]
["Glyoxylate and dicarboxylate metabolism",0.111111111111111,0.540577506575,3,0.0208323236355,1.6812622861831372,"up"]
["RNA degradation",0.0657894736842105,0.540577506575,5,0.0219880987061,1.657812322123883,"up"]
["Synthesis and degradation of ketone bodies",0.181818181818182,0.540577506575,2,0.0261961240988,1.5817629608567498,"up"]
["Non-small cell lung cancer",0.0740740740740741,0.540577506575,4,0.0274265875935,1.561828223802814,"up"]
["Systemic lupus erythematosus",0.0482758620689655,0.540577506575,7,0.0313761266332,1.5034006708719503,"up"]
["Non-homologous end-joining",0.153846153846154,0.540577506575,2,0.0343642251488,1.4638934442005582,"up"]
["Endocytosis",0.0398230088495575,0.540577506575,9,0.0441971552776,1.354605682845465,"up"]
["Metabolic pathways",0.0270700636942675,0.540577506575,34,0.0530626490366,1.2752110726111319,"up"]
["2-Oxocarboxylic acid metabolism",0.117647058823529,0.540577506575,2,0.0531593169907,1.2744206076592464,"up"]
["Renal cell carcinoma",0.0588235294117647,0.540577506575,4,0.0538378420141,1.2689123562906006,"up"]
["Primary bile acid biosynthesis",0.111111111111111,0.540577506575,2,0.0583146639102,1.2342222230367963,"up"]
["Glycine, serine and threonine metabolism",0.0714285714285714,0.540577506575,3,0.0587648658222,1.230882251135,"up"]
["Complement and coagulation cascades",0.0547945205479452,0.540577506575,4,0.0657099029827,1.182369174022529,"up"]
["Chronic myeloid leukemia",0.0533333333333333,0.540577506575,4,0.0708095803062,1.1499079797022922,"up"]
["Biosynthesis of amino acids",0.0533333333333333,0.540577506575,4,0.0708095803062,1.1499079797022922,"up"]
["Endometrial cancer",0.115384615384615,0.244564692143,6,0.0022269961524,2.652280533299546,"down"]
["Amyotrophic lateral sclerosis (ALS)",0.103448275862069,0.244564692143,6,0.00367107113874,2.4352071995704114,"down"]
["Renal cell carcinoma",0.0882352941176471,0.244564692143,6,0.00747424827508,2.126432480114105,"down"]
["Colorectal cancer",0.0857142857142857,0.244564692143,6,0.00848659174422,2.0712666894808303,"down"]
["Thyroid cancer",0.129032258064516,0.244564692143,4,0.00852959354213,2.0690716636291806,"down"]
["Thyroid hormone signaling pathway",0.0677966101694915,0.244564692143,8,0.00930096617893,2.031471934845758,"down"]
["MAPK signaling pathway",0.0509803921568627,0.244564692143,13,0.0103388141598,1.9855292710475965,"down"]
["Chronic myeloid leukemia",0.08,0.244564692143,6,0.0114416230242,1.9415123653631143,"down"]
["Acute myeloid leukemia",0.0862068965517241,0.293992608123,5,0.0154732951644,1.8104171898994774,"down"]
["VEGF signaling pathway",0.0819672131147541,0.318071098997,5,0.0186006490642,1.7304719009389515,"down"]
["Apoptosis",0.0681818181818182,0.333096519704,6,0.0223742718671,1.6502510891627094,"down"]
["Signaling pathways regulating pluripotency of stem cells",0.0567375886524823,0.333096519704,8,0.0233751943652,1.6312447692732888,"down"]
["Long-term potentiation",0.0746268656716418,0.342527887169,5,0.0260401317731,1.5843568224008735,"down"]
["B cell receptor signaling pathway",0.072463768115942,0.34930891253,5,0.028886774602,1.539300947278446,"down"]
["Ubiquitin mediated proteolysis",0.0536912751677852,0.34930891253,8,0.0306479693215,1.5135982957518754,"down"]
["Spliceosome",0.0529801324503311,0.34930891253,8,0.0326838748566,1.4856664610416659,"down"]
["Dopaminergic synapse",0.0534351145038168,0.427586229957,7,0.0425085725688,1.3715234783286157,"down"]
["Non-small cell lung cancer",0.0740740740740741,0.434170256036,4,0.0457021322143,1.3400635376259242,"down"]
["cGMP-PKG signaling pathway",0.0467836257309941,0.468128757663,8,0.0582193105319,1.2349329420432797,"down"]
["Ras signaling pathway",0.0429184549356223,0.468128757663,10,0.0584982320729,1.2328572589192899,"down"]

{"sheet":"Supplementary material 8B","index":1,"n_rows":42,"n_cols":7,"rows_kept":42,"merged":[[0,0,0,15]],"flags":["formulas_cached_only"]}
["Supplementary material 8B  Total set of the top 20 KEGG enrichment pathways for differentially expressed mRNAs in MM_F_P vs ww_F_P. "]
["pathway_term","rich_factor","qvalue","gene_number","Pvalue","-Log10(Pvalue)","regulation"]
["Endocrine and other factor-regulated calcium reabsorption",0.0454545454545455,0.612307714445,2,0.0265539979479,1.575870082642836,"up"]
["Viral carcinogenesis",0.0181818181818182,0.612307714445,4,0.0354687877922,1.4501536540472177,"up"]
["Hedgehog signaling pathway",0.0377358490566038,0.612307714445,2,0.0369027027499,1.4329418249958885,"up"]
["Wnt signaling pathway",0.0212765957446809,0.612307714445,3,0.0453308593828,1.3436060475049554,"up"]
["Inositol phosphate metabolism",0.0327868852459016,0.612307714445,2,0.0471805858065,1.3262366711030096,"up"]
["Hippo signaling pathway",0.0196078431372549,0.612307714445,3,0.0550945982007,1.2588909798529522,"up"]
["Synaptic vesicle cycle",0.0298507462686567,0.612307714445,2,0.0554901129984,1.2557843908006905,"up"]
["Thyroid hormone synthesis",0.0285714285714286,0.612307714445,2,0.0598234193042,1.223128767792383,"up"]
["Phosphatidylinositol signaling system",0.025,0.612307714445,2,0.0750529813263,1.1246320516173212,"up"]
["Insulin secretion",0.0232558139534884,0.612307714445,2,0.0847185313362,1.0720215816790506,"up"]
["Calcium signaling pathway",0.0161290322580645,0.612307714445,3,0.0865381477781,1.0627924044730812,"up"]
["Selenocompound metabolism",0.0588235294117647,0.612307714445,1,0.0945539661513,1.0243202495635417,"up"]
["Epstein-Barr virus infection",0.0153061224489796,0.612307714445,3,0.0972874104501,1.0119433562969469,"up"]
["Herpes simplex infection",0.0140845070422535,0.612307714445,3,0.116721549438,0.9328489559680395,"up"]
["Steroid biosynthesis",0.0454545454545455,0.612307714445,1,0.119205895756,0.9237022644701349,"up"]
["T cell receptor signaling pathway",0.0185185185185185,0.612307714445,2,0.122935641309,0.9103221888807433,"up"]
["Dorso-ventral axis formation",0.04,0.612307714445,1,0.133676019266,0.8739464957639093,"up"]
["Chagas disease (American trypanosomiasis)",0.0173913043478261,0.612307714445,2,0.135843431379,0.8669613567663224,"up"]
["Glycosphingolipid biosynthesis - lacto and neolacto series",0.0384615384615385,0.612307714445,1,0.138446755875,0.8587172163148886,"up"]
["Thyroid hormone signaling pathway",0.0169491525423729,0.612307714445,2,0.141465151801,0.8493505300652111,"up"]
["2-Oxocarboxylic acid metabolism",0.117647058823529,0.590069590035,2,0.00546360731514,2.262520522173578,"down"]
["RNA transport",0.0239520958083832,0.689068271937,4,0.0183404097735,1.7365909652645917,"down"]
["Fanconi anemia pathway",0.0392156862745098,0.689068271937,2,0.0386902162856,1.4123988424839748,"down"]
["Axon guidance",0.0236220472440945,0.689068271937,3,0.0411639161868,1.3854833147305032,"down"]
["Lysine degradation",0.037037037037037,0.689068271937,2,0.0427527214232,1.3690362350536796,"down"]
["ABC transporters",0.0363636363636364,0.689068271937,2,0.0441409048312,1.355158768610486,"down"]
["Inositol phosphate metabolism",0.0327868852459016,0.689068271937,2,0.0528103718653,1.2772807744073733,"down"]
["Legionellosis",0.0266666666666667,0.689068271937,2,0.0750857809694,1.1244422977654107,"down"]
["Biosynthesis of amino acids",0.0266666666666667,0.689068271937,2,0.0750857809694,1.1244422977654107,"down"]
["cGMP-PKG signaling pathway",0.0175438596491228,0.689068271937,3,0.0827722508845,1.0821152345628282,"down"]
["Phosphatidylinositol signaling system",0.025,0.689068271937,2,0.0836511060647,1.0775283122673955,"down"]
["Protein processing in endoplasmic reticulum",0.0170454545454545,0.689068271937,3,0.088328160174,1.0539008155791818,"down"]
["Influenza A",0.0166666666666667,0.689068271937,3,0.0928833866449,1.0320619580586914,"down"]
["Apoptosis",0.0227272727272727,0.689068271937,2,0.0979307236134,1.009081036465573,"down"]
["Pantothenate and CoA biosynthesis",0.0555555555555556,0.689068271937,1,0.105701370397,0.9759193821154964,"down"]
["Pentose and glucuronate interconversions",0.0344827586206897,0.689068271937,1,0.161744239646,0.7911711773331602,"down"]
["AMPK signaling pathway",0.0158730158730159,0.689068271937,2,0.172907742777,0.7621855586634096,"down"]
["Citrate cycle (TCA cycle)",0.0303030303030303,0.689068271937,1,0.181246656691,0.7417299957585779,"down"]
["Tight junction",0.0148148148148148,0.689068271937,2,0.191828184396,0.7170875836700049,"down"]
["Measles",0.0147058823529412,0.689068271937,2,0.193947803644,0.7123151341907207,"down"]

{"sheet":"Supplementary material 8C","index":2,"n_rows":42,"n_cols":7,"rows_kept":42,"merged":[[0,0,0,13]],"flags":["formulas_cached_only"]}
["Supplementary material 8C  Total set of the top 20 KEGG enrichment pathways for differentially expressed mRNAs in MM_L_P vs ww_L_P."]
["pathway_term","rich_factor","qvalue","gene_number","Pvalue","-Log10(Pvalue)","regualtion"]
["MicroRNAs in cancer",0.0271739130434783,0.00889897794153,5,0.000171134191183,3.7666632133773654,"up"]
["Vasopressin-regulated water reabsorption",0.0425531914893617,0.146027579741,2,0.00799544762105,2.0971572174824464,"up"]
["Ubiquitin mediated proteolysis",0.0201342281879195,0.146027579741,3,0.00842466806198,2.074447201636489,"up"]
["Non-homologous end-joining",0.0769230769230769,0.37509774925,1,0.0376678686432,1.4240289527376484,"up"]
["Cell cycle",0.0149253731343284,0.37509774925,2,0.0536365192542,1.2705394134778345,"up"]
["Biosynthesis of unsaturated fatty acids",0.0434782608695652,0.37509774925,1,0.0637140728522,1.1957646322323516,"up"]
["Dorso-ventral axis formation",0.04,0.37509774925,1,0.0688393378813,1.162163315507183,"up"]
["Homologous recombination",0.0384615384615385,0.37509774925,1,0.0713915941199,1.1463529204682648,"up"]
["Transcriptional misregulation in cancer",0.0119047619047619,0.37509774925,2,0.0791635285949,1.101474856012633,"up"]
["Phagosome",0.0118343195266272,0.37509774925,2,0.0799632332582,1.0971096538009717,"up"]
["Protein processing in endoplasmic reticulum",0.0113636363636364,0.37509774925,2,0.0856315256013,1.067366318569318,"up"]
["Galactose metabolism",0.03125,0.37509774925,1,0.0865610190577,1.0626776393847943,"up"]
["Nicotine addiction",0.0238095238095238,0.394902238455,1,0.111302604952,0.95349467121749,"up"]
["Fatty acid metabolism",0.0208333333333333,0.394902238455,1,0.125829363293,0.900218000956911,"up"]
["Starch and sucrose metabolism",0.0204081632653061,0.394902238455,1,0.128227636645,0.8920183621112908,"up"]
["Glycerolipid metabolism",0.0169491525423729,0.394902238455,1,0.151856631925,0.8185662367023288,"up"]
["MAPK signaling pathway",0.00784313725490196,0.394902238455,2,0.156397128763,0.8057712242546333,"up"]
["Inositol phosphate metabolism",0.0163934426229508,0.394902238455,1,0.156506138379,0.8054686241760153,"up"]
["Steroid hormone biosynthesis",0.0151515151515152,0.394902238455,1,0.168020315489,0.7746382041589249,"up"]
["mTOR signaling pathway",0.0151515151515152,0.394902238455,1,0.168020315489,0.7746382041589249,"up"]
["Insulin secretion",0.0348837209302326,0.712030727057,3,0.0286127113732,1.543440986003716,"down"]
["Ribosome",0.0208333333333333,0.712030727057,5,0.0362244407778,1.440998310314766,"down"]
["Tuberculosis",0.0207253886010363,0.712030727057,4,0.0593693879341,1.226437428389305,"down"]
["ABC transporters",0.0363636363636364,0.712030727057,2,0.0669319417322,1.1743665756935322,"down"]
["Endocytosis",0.0176991150442478,0.712030727057,4,0.0923494908046,1.034565494824304,"down"]
["Amphetamine addiction",0.0298507462686567,0.712030727057,2,0.0929648133607,1.0316813982726598,"down"]
["Gastric acid secretion",0.0277777777777778,0.712030727057,2,0.104548489673,0.980682236700157,"down"]
["Hippo signaling pathway",0.0196078431372549,0.712030727057,3,0.110019489313,0.9585303752839153,"down"]
["Glycosphingolipid biosynthesis - globo series",0.0666666666666667,0.712030727057,1,0.112285996785,0.9496744013360625,"down"]
["Oxytocin signaling pathway",0.0191082802547771,0.712030727057,3,0.116328990018,0.9343120424862317,"down"]
["Hypertrophic cardiomyopathy (HCM)",0.025974025974026,0.712030727057,2,0.116498696644,0.9336789333803236,"down"]
["2-Oxocarboxylic acid metabolism",0.0588235294117647,0.712030727057,1,0.125409285162,0.9016703076413803,"down"]
["Dilated cardiomyopathy",0.0240963855421687,0.712030727057,2,0.131263986488,0.8818544103529767,"down"]
["Bile secretion",0.0240963855421687,0.712030727057,2,0.131263986488,0.8818544103529767,"down"]
["Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate",0.0555555555555556,0.712030727057,1,0.131898387682,0.8797605132109523,"down"]
["GnRH signaling pathway",0.0229885057471264,0.712030727057,2,0.141333745258,0.8497541323508756,"down"]
["HTLV-I infection",0.0145454545454545,0.712030727057,4,0.153819869862,0.8129875604120638,"down"]
["Mismatch repair",0.0454545454545455,0.712030727057,1,0.157379418577,0.8030520634818866,"down"]
["Circadian entrainment",0.0208333333333333,0.712030727057,2,0.164544704779,0.7837160891961862,"down"]
["Calcium signaling pathway",0.0161290322580645,0.712030727057,3,0.165712673205,0.7806442767796179,"down"]

{"sheet":"Supplementary material 8D","index":3,"n_rows":42,"n_cols":7,"rows_kept":42,"merged":[[0,0,0,17]],"flags":["formulas_cached_only"]}
["Supplementary material 8D  Total set of the top 20 KEGG enrichment pathways for differentially expressed mRNAs in ww_F_P vs ww_L_P."]
["pathway_term","rich_factor","qvalue","gene_number","Pvalue","-Log10(Pvalue)","regulation"]
["Signaling pathways regulating pluripotency of stem cells",0.0425531914893617,0.714776090364,6,0.019486926218,1.710256659180909,"up"]
["Colorectal cancer",0.0571428571428571,0.714776090364,4,0.0217532056974,1.6624767334632167,"up"]
["Ras signaling pathway",0.0343347639484979,0.714776090364,8,0.0234192809467,1.630426443408591,"up"]
["Adherens junction",0.0547945205479452,0.714776090364,4,0.0247537239958,1.6063594557540544,"up"]
["RNA degradation",0.0526315789473684,0.714776090364,4,0.0279920823794,1.5529647924147543,"up"]
["Bacterial invasion of epithelial cells",0.05,0.714776090364,4,0.0326848392644,1.4856536464409351,"up"]
["Leukocyte transendothelial migration",0.040650406504065,0.714776090364,5,0.0373219443283,1.428035739280949,"up"]
["Rap1 signaling pathway",0.0330188679245283,0.714776090364,7,0.0390396146852,1.4084944774017916,"up"]
["Hepatitis C",0.0378787878787879,0.714776090364,5,0.0476058756225,1.3223394423855641,"up"]
["Tight junction",0.037037037037037,0.714776090364,5,0.0513712438199,1.2892799188468245,"up"]
["Endocytosis",0.0309734513274336,0.714776090364,7,0.0513891306797,1.2891287289620852,"up"]
["Inositol phosphate metabolism",0.0491803278688525,0.817560879247,3,0.0641224219017,1.1929900827202602,"up"]
["Pancreatic cancer",0.046875,0.837174577902,3,0.0715016101388,1.1456841782475566,"up"]
["Hippo signaling pathway",0.0326797385620915,0.837174577902,5,0.0775127120563,1.1106270675172074,"up"]
["Focal adhesion",0.0285714285714286,0.837174577902,6,0.0914034657782,1.0390373366533525,"up"]
["Chagas disease (American trypanosomiasis)",0.0347826086956522,0.837174577902,4,0.0920559342517,1.03594821009644,"up"]
["Transcriptional misregulation in cancer",0.0297619047619048,0.837174577902,5,0.103831825661,0.9836695097777193,"up"]
["Viral carcinogenesis",0.0272727272727273,0.837174577902,6,0.107363461018,0.9691434968323897,"up"]
["Leishmaniasis",0.0384615384615385,0.837174577902,3,0.110484982675,0.9566967480838261,"up"]
["Phosphatidylinositol signaling system",0.0375,0.837174577902,3,0.116607791801,0.9332724287955504,"up"]
["Spliceosome",0.105960264900662,{"v":1.1762007013e-06,"d":"1.18E-06"},16,7.30559441799e-09,8.13634444202257,"down"]
["Herpes simplex infection",0.0469483568075117,0.20174191249,10,0.00250611071416,2.6009997467949204,"down"]
["Epstein-Barr virus infection",0.0459183673469388,0.249421516813,9,0.00464760590335,2.332770705328737,"down"]
["Notch signaling pathway",0.0769230769230769,0.434819545761,4,0.010802970081,1.9664568266929638,"down"]
["RNA polymerase",0.1,0.451160792725,3,0.014011204743,1.8535245206212692,"down"]
["SNARE interactions in vesicular transport",0.0882352941176471,0.511893395018,3,0.0190767724852,1.7194950997804688,"down"]
["Ubiquitin mediated proteolysis",0.0402684563758389,0.687371702569,6,0.0330946704358,1.4802419393567456,"down"]
["Glutamatergic synapse",0.0442477876106195,0.687371702569,5,0.0359176501252,1.4446920843388613,"down"]
["Cocaine addiction",0.0612244897959184,0.687371702569,3,0.045906314759,1.3381275698798138,"down"]
["RNA transport",0.0359281437125748,0.687371702569,6,0.0516703463268,1.2867586275328342,"down"]
["Proximal tubule bicarbonate reclamation",0.0909090909090909,0.687371702569,2,0.0521591973104,1.282669100680015,"down"]
["GABAergic synapse",0.0454545454545455,0.687371702569,4,0.0537380986441,1.2697177037938738,"down"]
["NF-kappa B signaling pathway",0.0449438202247191,0.687371702569,4,0.0555020629404,1.2556908744091824,"down"]
["Protein processing in endoplasmic reticulum",0.0340909090909091,0.695345616814,6,0.0629389889505,1.2010802378566332,"down"]
["Small cell lung cancer",0.0425531914893617,0.695345616814,4,0.0647837531193,1.1885338956005136,"down"]
["mRNA surveillance pathway",0.0404040404040404,0.752905593708,4,0.0748229161449,1.1259653696347585,"down"]
["Phototransduction",0.0689655172413793,0.757057713262,2,0.081979423113,1.0862951421273763,"down"]
["Pathways in cancer",0.0267857142857143,0.757057713262,9,0.0870030451355,1.0604655466641366,"down"]
["Circadian rhythm",0.0625,0.757057713262,2,0.0960227402285,1.0176259046037213,"down"]
["Hippo signaling pathway",0.0326797385620915,0.757057713262,5,0.0975806285844,1.0106363886232497,"down"]