{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["Supplementary material 7A","Supplementary material 7B","Supplementary material 7C","Supplementary material 7D"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supplementary material 7A","index":0,"n_rows":30,"n_cols":7,"rows_kept":30,"merged":[[0,0,0,10]],"flags":["formulas_cached_only"]}
["Supplementary material 7A  Total set of the top 20 KEGG enrichment pathways for differentially expressed lncRNA targets in MM_F_P vs MM_L_P. "]
["pathway_term","rich_factor","qvalue","gene_number","Pvalue","-Log10(Pvalue)","regulation"]
["Cell adhesion molecules (CAMs)",0.102564102564103,0.0483842335766,16,0.000215041038118,3.667478652049675,"up"]
["Staphylococcus aureus infection",0.138461538461538,0.0596332219219,9,0.000768332911152,3.114450563628799,"up"]
["Glutathione metabolism",0.150943396226415,0.0596332219219,8,0.000903412013926,3.044114138318487,"up"]
["Bile secretion",0.120481927710843,0.0596332219219,10,0.0010601461675,2.974634252317916,"up"]
["Metabolism of xenobiotics by cytochrome P450",0.112903225806452,0.358724541761,7,0.00797165648358,2.0984514242841454,"up"]
["Chemical carcinogenesis",0.0958904109589041,0.644946587473,7,0.017198575666,1.7645075185581696,"up"]
["Drug metabolism - cytochrome P450",0.1,0.684040809558,6,0.0224065838544,1.6496243516878213,"up"]
["Systemic lupus erythematosus",0.0689655172413793,0.684040809558,10,0.0349360375964,1.4567263537206676,"up"]
["Tuberculosis",0.0621761658031088,0.684040809558,12,0.0423359085947,1.3732911151546363,"up"]
["Phenylalanine metabolism",0.142857142857143,0.684040809558,3,0.0442627061174,1.3539620378573056,"up"]
["Sulfur relay system",0.222222222222222,0.684040809558,2,0.0498975300859,1.3019209513027103,"up"]
["Adipocytokine signaling pathway",0.0810810810810811,0.684040809558,6,0.0504951570389,1.2967502728148106,"up"]
["Small cell lung cancer",0.074468085106383,0.684040809558,7,0.0517712347263,1.28591147711928,"up"]
["Tight junction",0.0666666666666667,0.684040809558,9,0.051894135998,1.2848817143594986,"up"]
["Viral myocarditis",0.08,0.684040809558,6,0.0530705446156,1.275146455571364,"up"]
["Asthma",0.102564102564103,0.684040809558,4,0.0540915322729,1.2668707159467356,"up"]
["Ascorbate and aldarate metabolism",0.130434782608696,0.684040809558,3,0.0541695446318,1.266244815229259,"up"]
["Arachidonic acid metabolism",0.0779220779220779,0.684040809558,6,0.0584567151418,1.233165592602799,"up"]
["Intestinal immune network for IgA production",0.0862068965517241,0.684040809558,5,0.0584582616626,1.2331541031346744,"up"]
["Leishmaniasis",0.0769230769230769,0.684040809558,6,0.0612678134277,1.2127676188230858,"up"]
["Prion diseases",0.0303030303030303,0.0470990687758,1,0.0122850561572,1.9106228539412193,"down"]
["Primary immunodeficiency",0.0303030303030303,0.0470990687758,1,0.0122850561572,1.9106228539412193,"down"]
["Aminoacyl-tRNA biosynthesis",0.0208333333333333,0.0470990687758,1,0.0176621507909,1.7529564117582146,"down"]
["Olfactory transduction",0.00240384615384615,0.0696397473889,2,0.0348198736945,1.458172808574264,"down"]
["FoxO signaling pathway",0.00757575757575758,0.074153802276,1,0.0472958529895,1.3251769375440745,"down"]
["Cell adhesion molecules (CAMs)",0.00641025641025641,0.074153802276,1,0.055615351707,1.2548053119903737,"down"]
["MicroRNAs in cancer",0.00543478260869565,0.0745597324318,1,0.0652397658779,1.185487606155958,"down"]
["MAPK signaling pathway",0.00392156862745098,0.0892548406269,1,0.0892548406269,1.0493682211480502,"down"]

{"sheet":"Supplementary material 7B","index":1,"n_rows":42,"n_cols":7,"rows_kept":42,"merged":[[0,0,0,13]],"flags":["formulas_cached_only"]}
["Supplementary material 7B  Total set of the top 20 KEGG enrichment pathways for differentially expressed lncRNA targets in MM_F_P vs ww_F_P. "]
["pathway_term","rich_factor","qvalue","gene_number","Pvalue","-Log10(Pvalue)","regulation"]
["Phosphatidylinositol signaling system",0.0375,0.625042711214,3,0.012641499835,1.8982013966689628,"up"]
["Chagas disease (American trypanosomiasis)",0.0260869565217391,0.625042711214,3,0.0317340483338,1.4984745211274455,"up"]
["Platelet activation",0.0223880597014925,0.625042711214,3,0.0460723287373,1.3365598356700663,"up"]
["Inositol phosphate metabolism",0.0327868852459016,0.625042711214,2,0.0521736164424,1.2825490588777084,"up"]
["RNA transport",0.0179640718562874,0.625042711214,3,0.0772060108413,1.112348886534901,"up"]
["Apoptosis",0.0227272727272727,0.625042711214,2,0.096814663506,1.0140588596601148,"up"]
["Nitrogen metabolism",0.0555555555555556,0.625042711214,1,0.10501880938,0.9787329097075712,"up"]
["Epstein-Barr virus infection",0.0153061224489796,0.625042711214,3,0.11035614791,0.9572034674047794,"up"]
["Inflammatory mediator regulation of TRP channels",0.02,0.625042711214,2,0.119158693035,0.9238742688910353,"up"]
["Melanogenesis",0.0198019801980198,0.625042711214,2,0.121075103437,0.9169451512543808,"up"]
["Estrogen signaling pathway",0.0196078431372549,0.625042711214,2,0.122999147619,0.9100978982000123,"up"]
["Rap1 signaling pathway",0.0141509433962264,0.625042711214,3,0.130620185303,0.8839897044673666,"up"]
["TNF signaling pathway",0.0181818181818182,0.625042711214,2,0.138648371952,0.8580852256635726,"up"]
["Amoebiasis",0.0176991150442478,0.625042711214,2,0.144625005127,0.8397566126443236,"up"]
["Cholinergic synapse",0.0175438596491228,0.625042711214,2,0.146629206495,0.8337795156684895,"up"]
["Thyroid hormone signaling pathway",0.0169491525423729,0.625042711214,2,0.154702371792,0.810503027940699,"up"]
["AMPK signaling pathway",0.0158730158730159,0.625042711214,2,0.171092318737,0.7667694878581857,"up"]
["Vascular smooth muscle contraction",0.0158730158730159,0.625042711214,2,0.171092318737,0.7667694878581857,"up"]
["FoxO signaling pathway",0.0151515151515152,0.625042711214,2,0.183566873003,0.7362056900741492,"up"]
["Tyrosine metabolism",0.0294117647058824,0.625042711214,1,0.184906315162,0.7330482559951088,"up"]
["Prostate cancer",0.0459770114942529,0.810754138839,4,0.0133886936175,1.873261796579441,"down"]
["TNF signaling pathway",0.0363636363636364,0.810754138839,4,0.0280192000751,1.5525442676201584,"down"]
["MicroRNAs in cancer",0.0271739130434783,0.810754138839,5,0.0422761511491,1.3739045580437523,"down"]
["p53 signaling pathway",0.0384615384615385,0.810754138839,3,0.0480984211987,1.3178691788433357,"down"]
["Progesterone-mediated oocyte maturation",0.032258064516129,0.810754138839,3,0.0723652651737,1.1404698421342763,"down"]
["Small cell lung cancer",0.0319148936170213,0.810754138839,3,0.0741458503839,1.1299131495014474,"down"]
["PI3K-Akt signaling pathway",0.0196629213483146,0.810754138839,7,0.0743116702389,1.1289429773247543,"down"]
["Fatty acid degradation",0.0465116279069767,0.810754138839,2,0.0749168555642,1.1254204592703079,"down"]
["Viral carcinogenesis",0.0227272727272727,0.810754138839,5,0.0769584004815,1.1137439673381904,"down"]
["Type II diabetes mellitus",0.0444444444444444,0.810754138839,2,0.0807600594333,1.0928033701203654,"down"]
["Glycerophospholipid metabolism",0.0297029702970297,0.810754138839,3,0.0871427223741,1.0597688766520303,"down"]
["Fatty acid metabolism",0.0416666666666667,0.810754138839,2,0.0897770934495,1.0468344590733378,"down"]
["Ether lipid metabolism",0.0408163265306122,0.810754138839,2,0.0928461977851,1.0322358766819935,"down"]
["Endometrial cancer",0.0384615384615385,0.810754138839,2,0.102230860694,0.9904179828122143,"down"]
["Non-small cell lung cancer",0.037037037037037,0.810754138839,2,0.108626199814,0.964065413583813,"down"]
["ABC transporters",0.0363636363636364,0.810754138839,2,0.111862947501,0.9513137415377638,"down"]
["Cholinergic synapse",0.0263157894736842,0.810754138839,3,0.113579258238,0.944700971928272,"down"]
["VEGF signaling pathway",0.0327868852459016,0.810754138839,2,0.131778799403,0.8801544534968395,"down"]
["Pancreatic cancer",0.03125,0.810754138839,2,0.142020064054,0.8476502958113937,"down"]
["Glycosphingolipid biosynthesis - globo series",0.0666666666666667,0.810754138839,1,0.149034534745,0.8267130838606604,"down"]

{"sheet":"Supplementary material 7C","index":2,"n_rows":42,"n_cols":7,"rows_kept":42,"merged":[[0,0,0,13]],"flags":["formulas_cached_only"]}
["Supplementary material 7C  Total set of the top 20 KEGG enrichment pathways for differentially expressed lncRNA targets in MM_L_P vs ww_L_P. "]
["pathway_term","rich_factor","qvalue","gene_number","Pvalue","-Log10(Pvalue)","regulation"]
["Olfactory transduction",0.0504807692307692,{"v":4.24483384769e-08,"d":"4.24E-08"},42,2.49696108688e-10,9.602588225724332,"up"]
["Dorso-ventral axis formation",0.12,0.554154101227,3,0.00985336163507,2.0064155775743022,"up"]
["Thyroid hormone signaling pathway",0.0508474576271186,0.554154101227,6,0.0147772168522,1.8304073534614103,"up"]
["Insulin secretion",0.0581395348837209,0.554154101227,5,0.0153932651284,1.8126692504190467,"up"]
["Gap junction",0.0561797752808989,0.554154101227,5,0.0174860863388,1.7573073815823146,"up"]
["Prion diseases",0.0909090909090909,0.554154101227,3,0.0195583800433,1.7086671192514242,"up"]
["Long-term potentiation",0.0597014925373134,0.654600412173,4,0.0269541346189,1.5693746069356809,"up"]
["MicroRNAs in cancer",0.0380434782608696,0.707282895115,7,0.0342913535848,1.4648153716127588,"up"]
["TNF signaling pathway",0.0454545454545455,0.707282895115,5,0.0374443885649,1.4266132566800434,"up"]
["GnRH signaling pathway",0.0459770114942529,0.869885358396,4,0.0581103186182,1.2357467433231137,"up"]
["Vascular smooth muscle contraction",0.0396825396825397,0.869885358396,5,0.0593655161152,1.2264657521513402,"up"]
["Rap1 signaling pathway",0.0330188679245283,0.869885358396,7,0.0627380730349,1.2024688245474484,"up"]
["Progesterone-mediated oocyte maturation",0.043010752688172,0.869885358396,4,0.0700683764969,1.154477945109622,"up"]
["Inositol phosphate metabolism",0.0491803278688525,0.869885358396,3,0.0827054881248,1.0824656708194649,"up"]
["Inflammatory mediator regulation of TRP channels",0.04,0.869885358396,4,0.0854813072847,1.068128844694794,"up"]
["Melanogenesis",0.0396039603960396,0.869885358396,4,0.0878076924215,1.0564674359176929,"up"]
["Estrogen signaling pathway",0.0392156862745098,0.869885358396,4,0.0901644726551,1.0449645530261635,"up"]
["Toll-like receptor signaling pathway",0.0384615384615385,0.869885358396,4,0.0949681440238,1.0224220493932052,"up"]
["Thyroid cancer",0.0645161290322581,0.869885358396,2,0.0972224812325,1.012233299412142,"up"]
["Renal cell carcinoma",0.0441176470588235,0.890944641695,3,0.10481701667,0.979568205463372,"up"]
["Regulation of autophagy",0.09375,0.337141133922,3,0.00344600541092,2.462684044957969,"down"]
["Adipocytokine signaling pathway",0.0540540540540541,0.337141133922,4,0.00478214374357,2.3203773738285625,"down"]
["Cell adhesion molecules (CAMs)",0.032051282051282,0.630866769367,5,0.0134226972206,1.8721602061995877,"down"]
["Viral myocarditis",0.04,0.781478266483,3,0.0305463654073,1.5150404573513336,"down"]
["Hypertrophic cardiomyopathy (HCM)",0.038961038961039,0.781478266483,3,0.0325802060956,1.4870461727623552,"down"]
["Antigen processing and presentation",0.0365853658536585,0.781478266483,3,0.0379659680429,1.420605522156936,"down"]
["Adrenergic signaling in cardiomyocytes",0.0264900662251656,0.781478266483,4,0.0465456396633,1.3321209969353474,"down"]
["Oxytocin signaling pathway",0.0254777070063694,0.781478266483,4,0.0521738420737,1.282547180721212,"down"]
["Fanconi anemia pathway",0.0392156862745098,0.781478266483,2,0.0775652774506,1.110332649700334,"down"]
["Cytosolic DNA-sensing pathway",0.0344827586206897,0.781478266483,2,0.0958465177163,1.0184236612321158,"down"]
["AMPK signaling pathway",0.0238095238095238,0.781478266483,3,0.102474166142,0.9893856069602432,"down"]
["Autoimmune thyroid disease",0.0317460317460317,0.781478266483,2,0.109574960066,0.9602886789502432,"down"]
["Pancreatic cancer",0.03125,0.781478266483,2,0.112380214996,0.9493101413860993,"down"]
["Fatty acid biosynthesis",0.0769230769230769,0.781478266483,1,0.11499403805,0.9393246753777431,"down"]
["Non-homologous end-joining",0.0769230769230769,0.781478266483,1,0.11499403805,0.9393246753777431,"down"]
["Synaptic vesicle cycle",0.0298507462686567,0.781478266483,2,0.120905350448,0.9175544797957506,"down"]
["Herpes simplex infection",0.0187793427230047,0.781478266483,4,0.12104520035,0.9170524264026346,"down"]
["B cell receptor signaling pathway",0.0289855072463768,0.781478266483,2,0.126674707646,0.897310089349314,"down"]
["Glycosaminoglycan biosynthesis - keratan sulfate",0.0666666666666667,0.781478266483,1,0.130309666702,0.885023366024817,"down"]
["Gastric acid secretion",0.0277777777777778,0.781478266483,2,0.135447566255,0.8682287940381193,"down"]

{"sheet":"Supplementary material 7D","index":3,"n_rows":42,"n_cols":7,"rows_kept":42,"merged":[[0,0,0,16]],"flags":["formulas_cached_only"]}
["Supplementary material 7D  Total set of the top 20 KEGG enrichment pathways for differentially expressed lncRNA targets in ww_F_P vs ww_L_P. "]
["pathway_term","rich_factor","qvalue","gene_number","Pvalue","-Log10(Pvalue)","regulation"]
["Cell adhesion molecules (CAMs)",0.128205128205128,0.00091544718663,20,4.01511923961e-06,5.3963015526678175,"up"]
["Staphylococcus aureus infection",0.138461538461538,0.126054474958,9,0.00110574100841,2.956346583510516,"up"]
["Glutathione metabolism",0.132075471698113,0.371334625054,7,0.0048859819086,2.3110481454284306,"up"]
["Viral myocarditis",0.106666666666667,0.453888380945,8,0.00862148770279,2.0644177869172373,"up"]
["Graft-versus-host disease",0.122448979591837,0.453888380945,6,0.0122976063738,1.910179412122601,"up"]
["Bile secretion",0.0963855421686747,0.453888380945,8,0.0145842047011,1.8361172486362487,"up"]
["Allograft rejection",0.111111111111111,0.453888380945,6,0.0183521724227,1.7363125191313757,"up"]
["Asthma",0.128205128205128,0.453888380945,5,0.0183868982787,1.7354915265562518,"up"]
["Systemic lupus erythematosus",0.0758620689655172,0.453888380945,11,0.0218414291713,1.6607189474278303,"up"]
["Intestinal immune network for IgA production",0.103448275862069,0.453888380945,6,0.0244649860137,1.6114550281842248,"up"]
["Type I diabetes mellitus",0.101694915254237,0.453888380945,6,0.0261819460147,1.5819980769587993,"up"]
["Small cell lung cancer",0.0851063829787234,0.453888380945,8,0.0270344432901,1.5680825692556202,"up"]
["Leishmaniasis",0.0897435897435897,0.453888380945,7,0.0296657532132,1.5277446204536576,"up"]
["Toxoplasmosis",0.0746268656716418,0.453888380945,10,0.0306295018649,1.5138600661736539,"up"]
["Metabolism of xenobiotics by cytochrome P450",0.0967741935483871,0.453888380945,6,0.0318062677803,1.4974872890038047,"up"]
["Tight junction",0.0740740740740741,0.453888380945,10,0.0319087754269,1.4960898625424626,"up"]
["Autoimmune thyroid disease",0.0952380952380952,0.453888380945,6,0.0338425547196,1.4705368602090532,"up"]
["Antigen processing and presentation",0.0853658536585366,0.466257416248,7,0.0368097960196,1.4340365891767397,"up"]
["Leukocyte transendothelial migration",0.0731707317073171,0.516434769446,9,0.0430362307872,1.3661657721930132,"up"]
["Phenylalanine metabolism",0.142857142857143,0.536762592691,3,0.050309270451,1.2983519804560497,"up"]
["Spliceosome",0.0132450331125828,0.175540481957,2,0.0103424211545,1.9853777812660103,"down"]
["Vitamin digestion and absorption",0.0454545454545455,0.175540481957,1,0.0229475799299,1.6392631087545704,"down"]
["Cocaine addiction",0.0204081632653061,0.175540481957,1,0.049241194876,1.3076714171185198,"down"]
["Fat digestion and absorption",0.0196078431372549,0.175540481957,1,0.0511616088754,1.2910558067515974,"down"]
["Glutathione metabolism",0.0188679245283019,0.175540481957,1,0.0530782987374,1.2750830055664584,"down"]
["Drug metabolism - cytochrome P450",0.0166666666666667,0.175540481957,1,0.0597574854922,1.2236076852863254,"down"]
["Metabolism of xenobiotics by cytochrome P450",0.0161290322580645,0.175540481957,1,0.0616575022134,1.2100140728127142,"down"]
["Thyroid hormone synthesis",0.0142857142857143,0.175540481957,1,0.0692207753749,1.1597635402751405,"down"]
["Chemical carcinogenesis",0.0136986301369863,0.175540481957,1,0.0720418864822,1.1424149233083252,"down"]
["Legionellosis",0.0133333333333333,0.175540481957,1,0.0739180649629,1.1312494106588162,"down"]
["Antigen processing and presentation",0.0121951219512195,0.175540481957,1,0.0804560542305,1.094441270148306,"down"]
["Glutamatergic synapse",0.00884955752212389,0.214280451391,1,0.108881163617,0.96304724645882,"down"]
["Neurotrophin signaling pathway",0.00813008130081301,0.214280451391,1,0.117869214647,0.9285996101277367,"down"]
["Dopaminergic synapse",0.00763358778625954,0.214280451391,1,0.124996929978,0.9031006534718409,"down"]
["Hippo signaling pathway",0.0065359477124183,0.223283460904,1,0.144314206625,0.8406909138465862,"down"]
["Phagosome",0.00591715976331361,0.223283460904,1,0.158105281211,0.8010536230311817,"down"]
["Protein processing in endoplasmic reticulum",0.00568181818181818,0.223283460904,1,0.16407154713,0.784966726660658,"down"]
["Influenza A",0.00555555555555556,0.223283460904,1,0.167462595678,0.7760821814909425,"down"]
["Huntington\" \"s disease",0.00480769230769231,0.234882995517,1,0.190832857532,0.7193468465277428,"down"]
["Proteoglycans in cancer",0.00467289719626168,0.234882995517,1,0.195758179388,0.7082800827113452,"down"]