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[]
[null,"gRNA 1",{"$nulls":8},"Control",{"$nulls":8},"Percentage Change (%)"]
[null,"CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average","CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average"]
[null,1,12.649999999999999,10.94,19.36,11.275,11.175,14.614999999999998,12.14,{"$f":"AVERAGE(C4:I4)","v":13.164999999999997},1,13.55,13.065,12.685,9.94,11.105,7.465,8.475,{"$f":"AVERAGE(L4:R4)","v":10.897857142857143},{"$f":"J4-S4","v":2.2671428571428542}]
[null,2,12.705,22.785,24.11,15.05,15.42,21.6,26.63,{"$f":"AVERAGE(C5:I5)","v":19.75714285714286},2,15.425,15.185,12.135,15.49,12.275,17.505,19.47,{"$f":"AVERAGE(L5:R5)","v":15.355},{"$f":"J5-S5","v":4.402142857142859}]
[null,3,19.495,19.785,22.634999999999998,22.16,21.215,17.775,20.25,20.47357142857143,3,20.075,19.98,19.465,20.69,20.07,15.97,16.88,19.018571428571427,1.4550000000000018]
[null,4,25.634999999999998,23.04,29.125,27.78,27.5,27.64,30.29,27.28714285714285,4,24.395,22.955,21.55,23.725,25.945,19.28,22.365,22.887857142857143,4.399285714285707]
[null,5,23.355,21.28,25.59,24.53,25.82,21.585,21.33,23.35571428571429,5,24.195,24.205,23.75,23.56,23.195,18.43,18.78,22.302142857142858,1.0535714285714306]
[null,6,20.869999999999997,20.175,21.425,19.895,20.505,19.215,19.18,20.180714285714284,6,20.59,21.165,19.085,19.725,20.455,14.39,16.205,18.802142857142858,1.3785714285714263]
[null,7,18.435000000000002,19.05,26.445,25.18,21.869999999999997,23.43,24.674999999999997,22.726428571428567,7,17.655,16.295,18.76,20.105,17.815,18.15,19.14,18.274285714285714,4.452142857142853]
[null,8,22.72,24,31.84,30.32,27.32,27.645,30.86,27.814999999999998,8,21.375,19.94,26.295,27.025,22.39,22.735,23.97,23.389999999999997,4.425000000000001]
[null,9,8.52,6.645,12.475,12.295,9.21,8.26,9.87,9.610714285714286,9,7.475,6.73,10.145,7.9,7.58,6.64,7.905,7.767857142857143,1.8428571428571425]
[null,10,18.84,17.815,24.645,22.4,23.855,23.93,26.4,22.555,10,15.2,14.685,18.455,21.335,18.49,17.74,20.895,18.11428571428571,4.440714285714289]
[null,11,10.379999999999999,10.989999999999998,19.465,16.67,14.405,17.814999999999998,17.485,15.315714285714284,11,4.975,5.46,7.66,8.54,7.425,5.81,7.76,6.804285714285713,8.51142857142857]
[null,12,2.61,2.355,4.98,4.074999999999999,3.38,4.494999999999999,5.33,3.8892857142857133,12,1.27,1.245,2.6,2.195,2.625,2.055,1.79,1.9685714285714286,1.9207142857142847]
[null,13,7.654999999999999,7.35,16.509999999999998,13.705,11.09,14.05,12.239999999999998,11.799999999999999,13,3.13,3.1,5.685,6.955,5.795,6.48,6.105,5.321428571428571,6.478571428571428]
[null,14,10.145,10.325,15.785,18.015,9.969999999999999,19.765,16.835,14.405714285714286,14,5.45,5.67,4.89,7.505,3.83,9.825,8.34,6.501428571428572,7.904285714285714]
[null,15,4.74,5.055,8.545,8.58,5.455,9.655000000000001,5.6899999999999995,6.817142857142857,15,1.585,1.685,2.455,2.46,2.125,2.67,2.5,2.2114285714285713,4.605714285714285]
[null,16,4.4350000000000005,4.52,8.815,9.865,5.4350000000000005,8.59,8.955,7.230714285714285,16,2.32,2.68,2.97,3.365,3.085,4.555,3.415,3.198571428571429,4.032142857142857]
[null,"gRNA 2",{"$nulls":8},"Control",{"$nulls":8},"Percentage Change (%)"]
[null,"CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average","CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average"]
[null,1,24.119999999999997,16.555,16.455000000000002,18.955,13.47,19.745,11.89,{"$f":"AVERAGE(C22:I22)","v":17.312857142857144},1,13.55,13.065,12.685,9.94,11.105,7.465,8.475,{"$f":"AVERAGE(L22:R22)","v":10.897857142857143},{"$f":"J22-S22","v":6.415000000000001}]
[null,2,18.115000000000002,12.65,16,12.350000000000001,14.614999999999998,13.735,14.375,{"$f":"AVERAGE(C23:I23)","v":14.54857142857143},2,15.425,15.185,12.135,15.49,12.275,17.505,19.47,{"$f":"AVERAGE(L23:R23)","v":15.355},{"$f":"J23-S23","v":-0.8064285714285706}]
[null,3,19.475,19.095,19.32,18.33,22.965,14.795,16.405,18.62642857142857,3,20.075,19.98,19.465,20.69,20.07,15.97,16.88,19.018571428571427,-0.3921428571428578]
[null,4,23.45,25.595,23.98,23.745,25.66,20.56,21.549999999999997,23.505714285714287,4,24.395,22.955,21.55,23.725,25.945,19.28,22.365,22.887857142857143,0.6178571428571438]
[null,5,24.405,25.03,24.42,23.735,25.66,20.385,20.09,23.389285714285712,5,24.195,24.205,23.75,23.56,23.195,18.43,18.78,22.302142857142858,1.0871428571428545]
[null,6,31.495,33.35,32.735,32.775,35.7,30.215,31.22,32.49857142857143,6,20.59,21.165,19.085,19.725,20.455,14.39,16.205,18.802142857142858,13.696428571428573]
[null,7,52.075,53.45,55.385000000000005,55.105000000000004,61.07,54.62,59.97,55.953571428571436,7,17.655,16.295,18.76,20.105,17.815,18.15,19.14,18.274285714285714,37.679285714285726]
[null,8,57.415000000000006,59.525,61.04,59.025,63.82,57.435,64.28,60.36285714285714,8,21.375,19.94,26.295,27.025,22.39,22.735,23.97,23.389999999999997,36.97285714285714]
[null,9,29.57,33.535,39.955,43.785,33.540000000000006,33.735,37.11,35.89,9,7.475,6.73,10.145,7.9,7.58,6.64,7.905,7.767857142857143,28.122142857142858]
[null,10,41.705,46.455,44.335,47.64,47.84,43.019999999999996,46.705,45.385714285714286,10,15.2,14.685,18.455,21.335,18.49,17.74,20.895,18.11428571428571,27.271428571428576]
[null,11,15.14,17.525,19.595,19.6,20.165,18.475,18.985,18.497857142857146,11,4.975,5.46,7.66,8.54,7.425,5.81,7.76,6.804285714285713,11.693571428571433]
[null,12,2.605,2.42,4.140000000000001,4.4350000000000005,5.5,4.5649999999999995,5.145,4.115714285714286,12,1.27,1.245,2.6,2.195,2.625,2.055,1.79,1.9685714285714286,2.147142857142857]
[null,13,8.879999999999999,10.52,15.01,16.21,12.825,10.735,11.16,12.19142857142857,13,3.13,3.1,5.685,6.955,5.795,6.48,6.105,5.321428571428571,6.869999999999999]
[null,14,15.475000000000001,19.725,22.25,22.174999999999997,16.91,21.28,20.96,19.825,14,5.45,5.67,4.89,7.505,3.83,9.825,8.34,6.501428571428572,13.323571428571427]
[null,15,12.965,13.89,15.785,15.825,10.605,12.754999999999999,11.42,13.320714285714287,15,1.585,1.685,2.455,2.46,2.125,2.67,2.5,2.2114285714285713,11.109285714285715]
[null,16,15.049999999999999,17.42,19.52,22.115000000000002,18.125,20.305,20.725,19.037142857142857,16,2.32,2.68,2.97,3.365,3.085,4.555,3.415,3.198571428571429,15.838571428571429]
[null,"gRNA 3",{"$nulls":8},"Control",{"$nulls":8},"Percentage Change (%)"]
[null,"CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average","CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average"]
[null,1,12.13,13.585,16.95,11.25,11.735,11.215,13.635,{"$f":"AVERAGE(C40:I40)","v":12.92857142857143},1,13.55,13.065,12.685,9.94,11.105,7.465,8.475,{"$f":"AVERAGE(L40:R40)","v":10.897857142857143},{"$f":"J40-S40","v":2.0307142857142875}]
[null,2,18.585,18.205,17.745,16.385,16.1,25.715,20.495,{"$f":"AVERAGE(C41:I41)","v":19.032857142857146},2,15.425,15.185,12.135,15.49,12.275,17.505,19.47,{"$f":"AVERAGE(L41:R41)","v":15.355},{"$f":"J41-S41","v":3.677857142857146}]
[null,3,24.175,26.875,23.325,25.255,25.95,22.29,22.725,24.370714285714286,3,20.075,19.98,19.465,20.69,20.07,15.97,16.88,19.018571428571427,5.352142857142859]
[null,4,31.665,35.17,34.39,33.945,37.535,33.805,36.925,34.776428571428575,4,24.395,22.955,21.55,23.725,25.945,19.28,22.365,22.887857142857143,11.888571428571431]
[null,5,23.35,24.815,24.22,24.625,26.485,20.2,23.29,23.854999999999997,5,24.195,24.205,23.75,23.56,23.195,18.43,18.78,22.302142857142858,1.552857142857139]
[null,6,22.155,23.535,19.645,19.295,24.23,18.155,23.035,21.435714285714287,6,20.59,21.165,19.085,19.725,20.455,14.39,16.205,18.802142857142858,2.633571428571429]
[null,7,15.235,15.125,15.97,14.895,16.205,39.295,16.42,19.020714285714284,7,17.655,16.295,18.76,20.105,17.815,18.15,19.14,18.274285714285714,0.7464285714285701]
[null,8,17.125,17.995,16.47,21.22,19.35,53.709999999999994,19.06,23.56142857142857,8,21.375,19.94,26.295,27.025,22.39,22.735,23.97,23.389999999999997,0.17142857142857437]
[null,9,5.085,5.755,5.205,5.01,5.27,4.14,4.81,5.039285714285714,9,7.475,6.73,10.145,7.9,7.58,6.64,7.905,7.767857142857143,-2.7285714285714295]
[null,10,13.02,14.27,14.29,14.395,15.845,11.649999999999999,13.63,13.87142857142857,10,15.2,14.685,18.455,21.335,18.49,17.74,20.895,18.11428571428571,-4.24285714285714]
[null,11,15.505,17.96,20.36,21.39,18.25,18.604999999999997,21.09,19.02285714285714,11,4.975,5.46,7.66,8.54,7.425,5.81,7.76,6.804285714285713,12.218571428571428]
[null,12,2.515,2.165,3.73,3.895,3.755,2.895,5.115,3.4385714285714286,12,1.27,1.245,2.6,2.195,2.625,2.055,1.79,1.9685714285714286,1.47]
[null,13,12.58,15.485,20.585,20.27,16.05,17.055,19.635,17.380000000000003,13,3.13,3.1,5.685,6.955,5.795,6.48,6.105,5.321428571428571,12.058571428571431]
[null,14,19.22,23.95,17.91,17.38,18.445,23.53,25.565,20.857142857142858,14,5.45,5.67,4.89,7.505,3.83,9.825,8.34,6.501428571428572,14.355714285714285]
[null,15,7.69,9.445,8.99,8.995,8.03,9.93,8.085,8.737857142857143,15,1.585,1.685,2.455,2.46,2.125,2.67,2.5,2.2114285714285713,6.526428571428571]
[null,16,7.61,9.355,10.325,9.485,8.94,10.120000000000001,12.735,9.795714285714284,16,2.32,2.68,2.97,3.365,3.085,4.555,3.415,3.198571428571429,6.597142857142856]
[null,"gRNA 4",{"$nulls":8},"Control",{"$nulls":8},"Percentage Change (%)"]
[null,"CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average","CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average"]
[null,1,15.38,15.285,22.44,13.215,13.305,10.26,15.455,{"$f":"AVERAGE(C58:I58)","v":15.04857142857143},1,13.55,13.065,12.685,9.94,11.105,7.465,8.475,{"$f":"AVERAGE(L58:R58)","v":10.897857142857143},{"$f":"J58-S58","v":4.150714285714287}]
[null,2,19.3,14.67,18.515,19.53,13.63,24.89,21.235,{"$f":"AVERAGE(C59:I59)","v":18.82428571428571},2,15.425,15.185,12.135,15.49,12.275,17.505,19.47,{"$f":"AVERAGE(L59:R59)","v":15.355},{"$f":"J59-S59","v":3.4692857142857108}]
[null,3,23.82,23.16,22.055,22.05,22.36,18.69,20.56,21.81357142857143,3,20.075,19.98,19.465,20.69,20.07,15.97,16.88,19.018571428571427,2.7950000000000017]
[null,4,31.68,30.745,29.345,28.94,30.375,28.335,31.365,30.112142857142857,4,24.395,22.955,21.55,23.725,25.945,19.28,22.365,22.887857142857143,7.224285714285713]
[null,5,26.025,24.7,24.34,24.47,25.735,21.365,23.2,24.262142857142855,5,24.195,24.205,23.75,23.56,23.195,18.43,18.78,22.302142857142858,1.9599999999999973]
[null,6,24.155,23.565,23.035,22.255,23.48,20.8,21.495,22.68357142857143,6,20.59,21.165,19.085,19.725,20.455,14.39,16.205,18.802142857142858,3.8814285714285717]
[null,7,26.415,28.615,24.405,30.77,29.16,28.715,31.295,28.482142857142858,7,17.655,16.295,18.76,20.105,17.815,18.15,19.14,18.274285714285714,10.207857142857144]
[null,8,33.725,35.69,25.585,39.695,36.17,35.215,38.58,34.95142857142857,8,21.375,19.94,26.295,27.025,22.39,22.735,23.97,23.389999999999997,11.561428571428575]
[null,9,29.48,33.29,32.5,34.64,29.13,30.9,33.52,31.922857142857143,9,7.475,6.73,10.145,7.9,7.58,6.64,7.905,7.767857142857143,24.155]
[null,10,47.22,52.33,51.43,54.755,48.755,51.35,51.8,51.09142857142857,10,15.2,14.685,18.455,21.335,18.49,17.74,20.895,18.11428571428571,32.977142857142866]
[null,11,10.54,12.07,13.535,14.86,12.875,12.14,12.455,12.639285714285714,11,4.975,5.46,7.66,8.54,7.425,5.81,7.76,6.804285714285713,5.835000000000001]
[null,12,2.77,4.575,5.95,5.62,4.075,4.31,4.095,4.485,12,1.27,1.245,2.6,2.195,2.625,2.055,1.79,1.9685714285714286,2.5164285714285715]
[null,13,9.21,10.4,13.255,14.67,10.635,11.49,12.745,11.772142857142857,13,3.13,3.1,5.685,6.955,5.795,6.48,6.105,5.321428571428571,6.450714285714286]
[null,14,15.69,18.23,18.345,14.29,14.165,16.07,19.66,16.635714285714283,14,5.45,5.67,4.89,7.505,3.83,9.825,8.34,6.501428571428572,10.13428571428571]
[null,15,3.755,4.515,5.38,4.78,4.055,4.11,5.765,4.622857142857143,15,1.585,1.685,2.455,2.46,2.125,2.67,2.5,2.2114285714285713,2.4114285714285715]
[null,16,4.565,5.665,7.165,5.765,5.235,4.84,5.73,5.566428571428572,16,2.32,2.68,2.97,3.365,3.085,4.555,3.415,3.198571428571429,2.3678571428571433]
[null,"gRNA 5",{"$nulls":8},"Control",{"$nulls":8},"Percentage Change (%)"]
[null,"CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average","CpG Site","Biol. 1","Biol. 2","Biol. 3","Biol. 4","Biol. 5","Biol. 6","Biol. 7","Average"]
[null,1,18.634999999999998,14.7,16.48,13.895,13.9,17.955,11.969999999999999,{"$f":"AVERAGE(C76:I76)","v":15.362142857142857},1,13.55,13.065,12.685,9.94,11.105,7.465,8.475,{"$f":"AVERAGE(L76:R76)","v":10.897857142857143},{"$f":"J76-S76","v":4.4642857142857135}]
[null,2,24.845,35.129999999999995,35.735,41.92,25.615000000000002,42.215,42.775,{"$f":"AVERAGE(C77:I77)","v":35.46214285714286},2,15.425,15.185,12.135,15.49,12.275,17.505,19.47,{"$f":"AVERAGE(L77:R77)","v":15.355},{"$f":"J77-S77","v":20.107142857142858}]
[null,3,36.535,38.805,40.155,43.21,37.86,43.835,39.6,40,3,20.075,19.98,19.465,20.69,20.07,15.97,16.88,19.018571428571427,20.981428571428573]
[null,4,51.32,51.65,52.44,56.105000000000004,50.04,62.47,55.39,54.20214285714285,4,24.395,22.955,21.55,23.725,25.945,19.28,22.365,22.887857142857143,31.31428571428571]
[null,5,36.26,37.31,38.14,39.584999999999994,37.135000000000005,39.989999999999995,34.875,37.61357142857143,5,24.195,24.205,23.75,23.56,23.195,18.43,18.78,22.302142857142858,15.311428571428575]
[null,6,31.490000000000002,31.935000000000002,29.415,31.39,31.314999999999998,33.42,29.799999999999997,31.252142857142864,6,20.59,21.165,19.085,19.725,20.455,14.39,16.205,18.802142857142858,12.450000000000006]
[null,7,35.894999999999996,39.67,40.78,45.325,42.155,49.625,44.365,42.545,7,17.655,16.295,18.76,20.105,17.815,18.15,19.14,18.274285714285714,24.270714285714288]
[null,8,38.14,42.41,45.349999999999994,48.394999999999996,44.165,51.285,48.095,45.40571428571429,8,21.375,19.94,26.295,27.025,22.39,22.735,23.97,23.389999999999997,22.015714285714292]
[null,9,9.495000000000001,8.149999999999999,8.76,13.69,7.465,7.960000000000001,7.984999999999999,9.072142857142858,9,7.475,6.73,10.145,7.9,7.58,6.64,7.905,7.767857142857143,1.3042857142857143]
[null,10,23.384999999999998,24.205,25.77,25.759999999999998,26,26.465,25.59,25.310714285714287,10,15.2,14.685,18.455,21.335,18.49,17.74,20.895,18.11428571428571,7.1964285714285765]
[null,11,15.285,16.13,19.259999999999998,21.229999999999997,15.935,19.965,19.6,18.200714285714287,11,4.975,5.46,7.66,8.54,7.425,5.81,7.76,6.804285714285713,11.396428571428574]
[null,12,3.0549999999999997,3.9050000000000002,5.050000000000001,5.6899999999999995,3.665,4.54,3.965,4.267142857142857,12,1.27,1.245,2.6,2.195,2.625,2.055,1.79,1.9685714285714286,2.298571428571428]
[null,13,31.855,32.94,40.114999999999995,44.295,33.760000000000005,46.58,43.465,39.00142857142857,13,3.13,3.1,5.685,6.955,5.795,6.48,6.105,5.321428571428571,33.68]
[null,14,37.465,38.230000000000004,27.98,33.05,38.49,47.43,46.989999999999995,38.51928571428572,14,5.45,5.67,4.89,7.505,3.83,9.825,8.34,6.501428571428572,32.01785714285715]
[null,15,32.715,33.045,27.880000000000003,32.32,33.019999999999996,44.675,41.495000000000005,35.02142857142858,15,1.585,1.685,2.455,2.46,2.125,2.67,2.5,2.2114285714285713,32.81000000000001]
[null,16,29.43,30.595,28.619999999999997,32.69,29.14,41.7,37.095,32.752857142857145,16,2.32,2.68,2.97,3.365,3.085,4.555,3.415,3.198571428571429,29.554285714285715]
[]
[]
["Additional file 11. dCas9-DNMT3a epigenetic modulation. b-values and mean percentage change at each CpG site per gRNA compared to non-targeting gRNA control."]