"Chemical Name"	"Chemical ID"	"CAS RN"	"Gene Symbol"	"Gene ID"	"Interaction"	"Interaction Actions"	"Reference Count"	"Organism Count"
"1,2-Dimethylhydrazine"	"D019813"	"540-73-8"	"SIRT5"	"23408"	"1,2-Dimethylhydrazine results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"2,6-dinitrotoluene"	"C023514"	"606-20-2"	"SIRT5"	"23408"	"2,6-dinitrotoluene affects the expression of SIRT5 mRNA"	"affects^expression"	"1"	"1"
"4-aminophenylarsenoxide"	"C032642"	"1122-90-3"	"SIRT5"	"23408"	"4-aminophenylarsenoxide binds to SIRT5 protein"	"affects^binding"	"1"	"1"
"4-aminophenylarsenoxide"	"C032642"	"1122-90-3"	"SIRT5"	"23408"	"Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SIRT5 protein]"	"affects^binding|decreases^reaction"	"1"	"1"
"abrine"	"C496492"	""	"SIRT5"	"23408"	"abrine results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Acetaminophen"	"D000082"	"103-90-2"	"SIRT5"	"23408"	"Acetaminophen affects the expression of SIRT5 mRNA"	"affects^expression"	"1"	"1"
"Acetaminophen"	"D000082"	"103-90-2"	"SIRT5"	"23408"	"Acetaminophen results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Air Pollutants"	"D000393"	""	"SIRT5"	"23408"	"Air Pollutants results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Arsenic Trioxide"	"D000077237"	"1327-53-3"	"SIRT5"	"23408"	"Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SIRT5 protein]"	"affects^binding|decreases^reaction"	"1"	"1"
"Atrazine"	"D001280"	"1912-24-9"	"SIRT5"	"23408"	"Atrazine results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Benzo(a)pyrene"	"D001564"	"50-32-8"	"SIRT5"	"23408"	"AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SIRT5 mRNA]"	"affects^expression|affects^reaction"	"1"	"1"
"Benzo(a)pyrene"	"D001564"	"50-32-8"	"SIRT5"	"23408"	"[Benzo(a)pyrene co-treated with Ethinyl Estradiol] results in decreased expression of SIRT5 mRNA"	"affects^cotreatment|decreases^expression"	"1"	"1"
"Benzo(a)pyrene"	"D001564"	"50-32-8"	"SIRT5"	"23408"	"Benzo(a)pyrene results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"2"	"1"
"Benzo(a)pyrene"	"D001564"	"50-32-8"	"SIRT5"	"23408"	"Benzo(a)pyrene results in decreased methylation of SIRT5 promoter"	"decreases^methylation"	"1"	"1"
"Benzo(a)pyrene"	"D001564"	"50-32-8"	"SIRT5"	"23408"	"Benzo(a)pyrene results in increased expression of SIRT5 mRNA"	"increases^expression"	"2"	"2"
"beta-methylcholine"	"C044887"	"7562-87-0"	"SIRT5"	"23408"	"beta-methylcholine affects the expression of SIRT5 mRNA"	"affects^expression"	"1"	"1"
"bisphenol A"	"C006780"	"80-05-7"	"SIRT5"	"23408"	"bisphenol A results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"6"	"4"
"bisphenol A"	"C006780"	"80-05-7"	"SIRT5"	"23408"	"bisphenol A results in increased expression of SIRT5 mRNA"	"increases^expression"	"2"	"2"
"bisphenol A"	"C006780"	"80-05-7"	"SIRT5"	"23408"	"bisphenol A results in increased methylation of SIRT5 gene"	"increases^methylation"	"1"	"1"
"Buspirone"	"D002065"	"36505-84-7"	"SIRT5"	"23408"	"Buspirone results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"butyraldehyde"	"C018475"	"123-72-8"	"SIRT5"	"23408"	"butyraldehyde results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"BZD9L1"	"C000719634"	""	"SIRT5"	"23408"	"BZD9L1 results in increased expression of SIRT5 protein"	"increases^expression"	"1"	"1"
"Carbon Tetrachloride"	"D002251"	"56-23-5"	"SIRT5"	"23408"	"Carbon Tetrachloride results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Cellulose"	"D002482"	"9004-34-6"	"SIRT5"	"23408"	"[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SIRT5 mRNA"	"affects^cotreatment|increases^expression"	"1"	"1"
"CGP 52608"	"C092451"	"87958-67-6"	"SIRT5"	"23408"	"CGP 52608 promotes the reaction [RORA protein binds to SIRT5 gene]"	"affects^binding|increases^reaction"	"1"	"1"
"Cisplatin"	"D002945"	"15663-27-1"	"SIRT5"	"23408"	"[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of SIRT5 mRNA"	"decreases^response to substance|increases^expression"	"1"	"1"
"Clofibric Acid"	"D002995"	"882-09-7"	"SIRT5"	"23408"	"Clofibric Acid affects the expression of SIRT5 mRNA"	"affects^expression"	"1"	"1"
"cobaltous chloride"	"C018021"	"7646-79-9"	"SIRT5"	"23408"	"cobaltous chloride results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Copper Sulfate"	"D019327"	"7758-98-7"	"SIRT5"	"23408"	"Copper Sulfate results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Cyclophosphamide"	"D003520"	"50-18-0"	"SIRT5"	"23408"	"Cyclophosphamide results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Cyclosporine"	"D016572"	"59865-13-3"	"SIRT5"	"23408"	"Cyclosporine results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"decamethrin"	"C017180"	"52820-00-5"	"SIRT5"	"23408"	"decamethrin results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Dexamethasone"	"D003907"	"50-02-2"	"SIRT5"	"23408"	"Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SIRT5 mRNA]"	"affects^expression|decreases^reaction"	"1"	"1"
"Dibutyl Phthalate"	"D003993"	"84-74-2"	"SIRT5"	"23408"	"Dibutyl Phthalate results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"diisobutyl phthalate"	"C025605"	"84-69-5"	"SIRT5"	"23408"	"diisobutyl phthalate results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"diisononyl phthalate"	"C012125"	"28553-12-0"	"SIRT5"	"23408"	"diisononyl phthalate results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Diquat"	"D004178"	"2764-72-9"	"SIRT5"	"23408"	"Diquat affects the expression of SIRT5 mRNA"	"affects^expression"	"1"	"1"
"Estradiol"	"D004958"	"50-28-2"	"SIRT5"	"23408"	"Estradiol affects the expression of SIRT5 mRNA"	"affects^expression"	"1"	"1"
"Estradiol"	"D004958"	"50-28-2"	"SIRT5"	"23408"	"Estradiol results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Ethinyl Estradiol"	"D004997"	"57-63-6"	"SIRT5"	"23408"	"[Benzo(a)pyrene co-treated with Ethinyl Estradiol] results in decreased expression of SIRT5 mRNA"	"affects^cotreatment|decreases^expression"	"1"	"1"
"Ethinyl Estradiol"	"D004997"	"57-63-6"	"SIRT5"	"23408"	"Ethinyl Estradiol results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"2"	"2"
"Gentamicins"	"D005839"	""	"SIRT5"	"23408"	"Gentamicins results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"GSK-J4"	"C000593030"	""	"SIRT5"	"23408"	"GSK-J4 results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Indomethacin"	"D007213"	"53-86-1"	"SIRT5"	"23408"	"Indomethacin results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"jinfukang"	"C544151"	""	"SIRT5"	"23408"	"jinfukang results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Ketone Bodies"	"D007657"	""	"SIRT5"	"23408"	"Ketone Bodies results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Mercury"	"D008628"	"7439-97-6"	"SIRT5"	"23408"	"Mercury analog results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Metformin"	"D008687"	"657-24-9"	"SIRT5"	"23408"	"Metformin results in decreased expression of SIRT5 protein"	"decreases^expression"	"1"	"1"
"Methamphetamine"	"D008694"	"537-46-2"	"SIRT5"	"23408"	"Methamphetamine results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"methylmercuric chloride"	"C004925"	"115-09-3"	"SIRT5"	"23408"	"methylmercuric chloride results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"mono-(2-ethylhexyl)phthalate"	"C016599"	"4376-20-9"	"SIRT5"	"23408"	"mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"mono-(2-ethylhexyl)phthalate"	"C016599"	"4376-20-9"	"SIRT5"	"23408"	"mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT5 protein"	"decreases^expression"	"1"	"1"
"Nanotubes, Carbon"	"D037742"	""	"SIRT5"	"23408"	"Nanotubes, Carbon results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride"	"C434926"	""	"SIRT5"	"23408"	"N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ABB protein results in increased expression of SIRT5 mRNA]"	"decreases^reaction|increases^expression"	"1"	"1"
"N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide"	"C560620"	""	"SIRT5"	"23408"	"N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide results in increased expression of SIRT5 protein"	"increases^expression"	"1"	"1"
"Pentachlorophenol"	"D010416"	"87-86-5"	"SIRT5"	"23408"	"Pentachlorophenol results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"pentanal"	"C046012"	"110-62-3"	"SIRT5"	"23408"	"pentanal results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"perfluorooctane sulfonic acid"	"C076994"	"1763-23-1"	"SIRT5"	"23408"	"[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SIRT5 mRNA"	"affects^cotreatment|increases^expression"	"1"	"1"
"perfluorooctane sulfonic acid"	"C076994"	"1763-23-1"	"SIRT5"	"23408"	"perfluorooctane sulfonic acid results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"perfluorooctanoic acid"	"C023036"	"335-67-1"	"SIRT5"	"23408"	"perfluorooctanoic acid results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"perfluoroundecanoic acid"	"C586085"	""	"SIRT5"	"23408"	"perfluoroundecanoic acid results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"pirinixic acid"	"C006253"	"50892-23-4"	"SIRT5"	"23408"	"pirinixic acid results in increased expression of SIRT5 mRNA"	"increases^expression"	"2"	"1"
"Plant Extracts"	"D010936"	""	"SIRT5"	"23408"	"[Plant Extracts co-treated with Resveratrol] results in increased expression of SIRT5 mRNA"	"affects^cotreatment|increases^expression"	"1"	"1"
"Potassium Dichromate"	"D011192"	"7778-50-9"	"SIRT5"	"23408"	"Potassium Dichromate results in increased expression of SIRT5 protein"	"increases^expression"	"1"	"1"
"Resveratrol"	"D000077185"	""	"SIRT5"	"23408"	"[Plant Extracts co-treated with Resveratrol] results in increased expression of SIRT5 mRNA"	"affects^cotreatment|increases^expression"	"1"	"1"
"Resveratrol"	"D000077185"	""	"SIRT5"	"23408"	"Resveratrol results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Resveratrol"	"D000077185"	""	"SIRT5"	"23408"	"SIRT5 protein affects the reaction [Resveratrol results in decreased acetylation of CYP11A1 protein]"	"affects^reaction|decreases^acetylation"	"1"	"1"
"Resveratrol"	"D000077185"	""	"SIRT5"	"23408"	"SIRT5 protein affects the reaction [Resveratrol results in increased expression of CYP11A1 protein]"	"affects^reaction|increases^expression"	"1"	"1"
"Sesame Oil"	"D012715"	"8008-74-0"	"SIRT5"	"23408"	"Sesame Oil results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Silver"	"D012834"	"7440-22-4"	"SIRT5"	"23408"	"Silver results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Smoke"	"D012906"	""	"SIRT5"	"23408"	"Smoke results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Sunitinib"	"D000077210"	""	"SIRT5"	"23408"	"Sunitinib results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Tetrachlorodibenzodioxin"	"D013749"	"1746-01-6"	"SIRT5"	"23408"	"Tetrachlorodibenzodioxin affects the expression of SIRT5 mRNA"	"affects^expression"	"1"	"1"
"Tetrachlorodibenzodioxin"	"D013749"	"1746-01-6"	"SIRT5"	"23408"	"Tetrachlorodibenzodioxin results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Thioacetamide"	"D013853"	"62-55-5"	"SIRT5"	"23408"	"Thioacetamide results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"2"
"Thiram"	"D013893"	"137-26-8"	"SIRT5"	"23408"	"Thiram results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Tobacco Smoke Pollution"	"D014028"	""	"SIRT5"	"23408"	"Tobacco Smoke Pollution results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Tretinoin"	"D014212"	"302-79-4"	"SIRT5"	"23408"	"Tretinoin results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"tributyltin"	"C011559"	"688-73-3"	"SIRT5"	"23408"	"tributyltin results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Trichloroethylene"	"D014241"	"79-01-6"	"SIRT5"	"23408"	"Trichloroethylene results in increased expression of SIRT5 mRNA"	"increases^expression"	"1"	"1"
"Triclosan"	"D014260"	"3380-34-5"	"SIRT5"	"23408"	"Triclosan results in decreased expression of SIRT5 protein"	"decreases^expression"	"1"	"1"
"tris(1,3-dichloro-2-propyl)phosphate"	"C016805"	"13674-87-8"	"SIRT5"	"23408"	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Urethane"	"D014520"	"51-79-6"	"SIRT5"	"23408"	"Urethane results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"valdecoxib"	"C406224"	""	"SIRT5"	"23408"	"valdecoxib results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"
"Valproic Acid"	"D014635"	"99-66-1"	"SIRT5"	"23408"	"Valproic Acid affects the expression of SIRT5 mRNA"	"affects^expression"	"1"	"1"
"Valproic Acid"	"D014635"	"99-66-1"	"SIRT5"	"23408"	"Valproic Acid results in decreased expression of SIRT5 mRNA"	"decreases^expression"	"1"	"1"