{"text_format":"3","workbook":"xls","n_sheets":9,"sheets":["Supplementary Table S1","Supplementary Table S2","Supplementary Table S3","Supplementary Table S4","Supplementary Table S5","Supplementary Table S6","Supplementary Table S7","Supplementary Table S8","Supplementary Table S9"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supplementary Table S1","index":0,"n_rows":69,"n_cols":25,"rows_kept":69,"flags":["formulas_cached_only"]}
["Supplementary Table S1.Information about 66 mitochondria-related proteins"]
[]
["id","trait","ncase","group_name","year","author","consortium","sex","pmid","population","unit","sample_size","build","ncontrol","category","subcategory","ontology","note","mr","nsnp","coverage","study_design","doi","priority","sd"]
["prot-a-1942","39S ribosomal protein L33, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-637","Cytochrome c oxidase subunit 4 isoform 2, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-332","Carbonic anhydrase 5A, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2235","[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1945","Ribosome-recycling factor, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-308","ES1 protein homolog, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-825","Dihydrolipoyl dehydrogenase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1281","GrpE protein homolog 1, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1356","Hydroxymethylglutaryl-CoA synthase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1997","N-acetylglutamate synthase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1964","Poly(A) RNA polymerase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1368","4-hydroxy-2-oxoglutarate aldolase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2190","Pyruvate carboxylase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1055","Phenylalanine--tRNA ligase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-640","Cytochrome c oxidase subunit 7A1, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-818","Diablo homolog, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-612","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2866","Steroidogenic acute regulatory protein, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-992","Persulfide dioxygenase ETHE1, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-641","Cytochrome c oxidase subunit 8A, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2129","ADP-ribose pyrophosphatase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2575","rRNA methyltransferase 3, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1220","Glutaredoxin-2, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1783","Leucine-rich PPR motif-containing protein, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1941","39S ribosomal protein L32, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-64","Apoptosis-inducing factor 1, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-534","Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1943","39S ribosomal protein L34, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2776","Essential MCU regulator, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1907","Malonyl-CoA decarboxylase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-63","Apoptosis-inducing factor 1, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2657","Succinate dehydrogenase assembly factor 2, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1944","39S ribosomal protein L52, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2737","NAD-dependent protein deacylase sirtuin-5, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2024","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2025","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2653","Protein SCO1 homolog, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2799","Superoxide dismutase [Mn], mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-3015","Transmembrane protein 70, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1965","Peptide chain release factor 1-like, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-385","Coiled-coil domain-containing protein 90B, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-896","Calcium uptake protein 3, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2454","tRNA pseudouridine synthase A, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2026","NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1572","Iron-sulfur cluster assembly enzyme ISCU, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-300","Complement component 1 Q subcomponent-binding protein, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1392","Serine protease HTRA2, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-638","Cytochrome c oxidase subunit 5B, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2236","[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1761","Lon protease homolog, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1339","Histidine triad nucleotide-binding protein 2, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2022","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2627","Serine--tRNA ligase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1940","39S ribosomal protein L14, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2526","Oligoribonuclease, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2128","Nucleoside diphosphate-linked moiety X motif 8, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1864","Methylmalonyl-CoA epimerase, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-203","ATP synthase subunit beta, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2041","NFU1 iron-sulfur cluster scaffold homolog, mitochondrial","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1970","Mitochondrial ubiquitin ligase activator of NFKB 1","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1961","Mitochondrial fission regulator 1","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2749","Mitochondrial glutamate carrier 2","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1953","Mitochondrial peptide methionine sulfoxide reductase","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-2764","Mitochondrial sodium/hydrogen exchanger 9B2","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-847","Mitochondrial import inner membrane translocase subunit TIM14","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]
["prot-a-1969","Mitochondrial ubiquitin ligase activator of NFKB 1","NA","public",2018,"Sun BB","NA","Males and Females",29875488,"European","NA",3301,"HG19/GRCh37","NA","Immune system","Protein","NA","NA",1,10534735,"NA","NA","NA",0,"NA"]

{"sheet":"Supplementary Table S2","index":1,"n_rows":12,"n_cols":6,"rows_kept":12,"merged":[[0,0,0,1],[2,0,3,0],[2,3,3,3]],"flags":["formulas_cached_only"]}
["Supplementary Table S2.Baseline characteristics of study participants."]
[]
["Characteristic","Subcohort 1 (n=2481)","Subcohort 2 (n=820)","p-value*",null,"Olink cohort (n=4,998)"]
[null,"Mean (SD) or %","Mean (SD) or %",null,null,"Mean (SD) or %"]
["Age (years)","43.6 (14.3)","44.1 (14.2)",0.37,null,"61.0 (6.7)"]
["Sex (% male)",{"v":0.516,"d":"51.6%"},{"v":0.495,"d":"49.5%"},0.31,null,{"v":0.593,"d":"59.3%"}]
["BMI","26.3 (4.8)","26.6 (4.9)",0.15,null,"26.6(4.7)"]
["Current smokers (%)",{"v":0.086,"d":"8.6%"},{"v":0.085,"d":"8.5%"},0.96,null,{"v":0.1,"d":"10.0%"}]
["Current alcohol use (%)",{"v":0.926,"d":"92.6%"},{"v":0.91,"d":"91.0%"},0.14,null,{"v":0.942,"d":"94.2%"}]
["*Age and BMI: p-values from two-sided t-test for difference between subcohorts."]
["Sex, smoking and alcohol use: p-values from two-sided Chi-squared test for difference between subcohorts."]
["BMI calculated from self-reported weight and height"]

{"sheet":"Supplementary Table S3","index":2,"n_rows":7,"n_cols":4,"rows_kept":7,"flags":["formulas_cached_only"]}
["Supplementary Table S3.Details of studies and datasets used for analyses"]
[]
["Exposure/Outcome","Consortium or cohort study","Participants","PMID/Web Source"]
["66 mitochondria-related proteins","SUN BB et al.GWAS","3,301 participants (2,481 and 820 in the two subcohorts)",29875488]
["NAFLD","Ghodsian N et al.GWAS","778,641 participants (8,434 cases and 770,180 controls)",34841290]
["Liver cirrhosis","FinnGen","377,277 participants(3,970 cases and 373,307 controls)","https://www.finngen.fi/en"]
["HCC","FinnGen","287,590 participants (453 cases and 287,137 controls)","https://www.finngen.fi/en"]

{"sheet":"Supplementary Table S4","index":3,"n_rows":26,"n_cols":35,"rows_kept":26,"merged":[[3,1,10,1],[3,2,10,2],[11,1,15,1],[11,2,15,2],[16,1,25,1],[16,2,25,2],[27,1,36,1],[27,2,36,2],[37,1,47,1],[37,2,47,2],[48,1,58,1],[48,2,58,2],[59,1,73,1],[59,2,73,2]],"flags":["formulas_cached_only"]}
["Supplementary Table S4.Detailed information on genetic instruments of NAFLD."]
[]
["outcome","id","protein","SNP","effect_allele.exposure","other_allele.exposure","effect_allele.outcome","other_allele.outcome","beta.exposure","beta.outcome","eaf.exposure","eaf.outcome","remove","palindromic","ambiguous","id.outcome","se.outcome","pval.outcome","outcome","mr_keep.outcome","pval_origin.outcome","data_source.outcome","pos.exposure","samplesize.exposure","pval.exposure","se.exposure","chr.exposure","id.exposure","exposure","mr_keep.exposure","pval_origin.exposure","data_source.exposure","action","mr_keep","samplesize.outcome"]
["NAFLD","prot-a-1942","39S ribosomal protein L33, mitochondrial（MRPL33）","rs114415646","T","C","T","C",0.3065,0.0069642,0.04158,0.027833,false,false,false,"ESx5q8",0.0470165,0.8822,"outcome",true,"reported","textfile",175225993,3301,{"v":1.58489e-06,"d":"1.58E-06"},0.0639,3,"prot-a-1942"," || id:prot-a-1942",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs17090693","C","T","C","T",0.5466,-0.0112946,0.25344,0.236581,false,false,false,"ESx5q8",0.0188841,0.5498,"outcome",true,"reported","textfile",94841331,3301,{"v":1.51356e-93,"d":"1.51E-93"},0.0266,14,"prot-a-1942"," || id:prot-a-1942",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs2829567","C","T","C","T",0.1201,0.0088713,0.48485,0.472167,false,false,false,"ESx5q8",0.0164431,0.5895,"outcome",true,"reported","textfile",26525097,3301,{"v":2.23872e-06,"d":"2.24E-06"},0.0254,21,"prot-a-1942"," || id:prot-a-1942",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs28929474","T","C","T","C",1.7387,0.22823,0.02269,0.016899,false,false,false,"ESx5q8",0.0593052,0.0001189,"outcome",true,"reported","textfile",94844947,3301,{"v":4.2658e-109,"d":"4.27E-109"},0.0784,14,"prot-a-1942"," || id:prot-a-1942",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs4547300","C","T","C","T",0.1221,0.0066849,0.45176,0.408549,false,false,false,"ESx5q8",0.0162445,0.6807,"outcome",true,"reported","textfile",83920383,3301,{"v":1.1749e-06,"d":"1.17E-06"},0.0251,15,"prot-a-1942"," || id:prot-a-1942",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs58352951","A","G","A","G",-0.2924,-0.0161097,0.05403,0.04672,false,false,false,"ESx5q8",0.0329971,0.6254,"outcome",true,"reported","textfile",94588271,3301,{"v":1e-07,"d":"1.00E-07"},0.0549,14,"prot-a-1942"," || id:prot-a-1942",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs59878806","A","G","A","G",0.301,0.0479163,0.03847,0.038767,false,false,false,"ESx5q8",0.0449741,0.2867,"outcome",true,"reported","textfile",105405737,3301,{"v":2.88403e-06,"d":"2.88E-06"},0.0643,7,"prot-a-1942"," || id:prot-a-1942",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs9934962","T","C","T","C",0.1453,0.0151437,0.22152,0.214712,false,false,false,"ESx5q8",0.020094,0.4511,"outcome",true,"reported","textfile",59040910,3301,{"v":1.47911e-06,"d":"1.48E-06"},0.0302,16,"prot-a-1942"," || id:prot-a-1942",true,"reported","igd",2,true,"NA"]
[null,"prot-a-1943","39S ribosomal protein L34, mitochondrial（MRPL34）","rs10734281","C","G","C","G",-0.1707,-0.0021389,0.87526,0.871769,false,true,false,"GwpsgA",0.0228377,0.9254,"outcome",true,"reported","textfile",19768375,3301,{"v":4.57088e-06,"d":"4.57E-06"},0.0372,11,"prot-a-1943"," || id:prot-a-1943",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs2319329","A","T","A","T",-0.1237,-0.0007859,0.31329,0.299205,false,true,false,"GwpsgA",0.0172813,0.9637,"outcome",true,"reported","textfile",147464988,3301,{"v":2.29087e-06,"d":"2.29E-06"},0.0262,3,"prot-a-1943"," || id:prot-a-1943",true,"reported","igd",2,true,"NA"]
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[{"$nulls":3},"rs5761606","T","G","T","G",-0.2298,0.0485783,0.08803,0.068588,false,false,false,"GwpsgA",0.0311731,0.1192,"outcome",true,"reported","textfile",26963743,3301,{"v":1.77828e-07,"d":"1.78E-07"},0.044,22,"prot-a-1943"," || id:prot-a-1943",true,"reported","igd",2,true,"NA"]
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[null,"prot-a-1055","Phenylalanine--tRNA ligase, mitochondrial（FARS2）","rs12453825","T","C","T","C",-0.1412,0.0448936,0.30662,0.373757,false,false,false,"voE0rx",0.0168482,0.007708,"outcome",true,"reported","textfile",17819635,3301,{"v":2.0893e-07,"d":"2.09E-07"},0.0272,17,"prot-a-1055"," || id:prot-a-1055",true,"reported","igd",2,true,"NA"]
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[{"$nulls":3},"rs2468789","G","T","G","T",-0.8031,0.0267298,0.97392,0.975149,false,false,false,"voE0rx",0.0604851,0.6585,"outcome",true,"reported","textfile",18231749,3301,{"v":3.01995e-25,"d":"3.02E-25"},0.0774,11,"prot-a-1055"," || id:prot-a-1055",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs34227891","G","A","G","A",0.1275,-0.0033844,0.28582,0.297217,false,false,false,"voE0rx",0.0184729,0.8546,"outcome",true,"reported","textfile",59810563,3301,{"v":3.54813e-06,"d":"3.55E-06"},0.0275,18,"prot-a-1055"," || id:prot-a-1055",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs34272872","C","T","C","T",-0.1244,0.0008845,0.33893,0.361829,false,false,false,"voE0rx",0.0177438,0.9602,"outcome",true,"reported","textfile",48316312,3301,{"v":3.31131e-06,"d":"3.31E-06"},0.0267,19,"prot-a-1055"," || id:prot-a-1055",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs34909003","T","A","T","A",0.1442,-0.0167493,0.22427,0.238569,false,true,false,"voE0rx",0.0204842,0.4135,"outcome",true,"reported","textfile",148726438,3301,{"v":1.47911e-06,"d":"1.48E-06"},0.03,7,"prot-a-1055"," || id:prot-a-1055",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs62153403","C","T","C","T",0.3138,-0.0417435,0.04918,0.035785,false,false,false,"voE0rx",0.0393887,0.2892,"outcome",true,"reported","textfile",106245470,3301,{"v":6.16595e-08,"d":"6.17E-08"},0.058,2,"prot-a-1055"," || id:prot-a-1055",true,"reported","igd",2,true,"NA"]
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[{"$nulls":3},"rs9536760","A","G","A","G",0.3447,-0.0818061,0.02757,0.025845,false,false,false,"voE0rx",0.0490258,0.09519,"outcome",true,"reported","textfile",55140850,3301,{"v":4.46684e-06,"d":"4.47E-06"},0.0752,13,"prot-a-1055"," || id:prot-a-1055",true,"reported","igd",2,true,"NA"]

{"sheet":"Supplementary Table S5","index":4,"n_rows":31,"n_cols":37,"rows_kept":31,"merged":[[3,1,20,1],[3,2,20,2],[21,1,30,1],[21,2,30,2]],"flags":["formulas_cached_only"]}
["Supplementary Table S5.Detailed information on genetic instruments of liver cirrhosis."]
[]
["outcome","id","protein","SNP","effect_allele.exposure","other_allele.exposure","effect_allele.outcome","other_allele.outcome","beta.exposure","beta.outcome","eaf.exposure","eaf.outcome","remove","palindromic","ambiguous","id.outcome","chr.outcome","pos.outcome","pval.outcome","se.outcome","outcome","mr_keep.outcome","pval_origin.outcome","data_source.outcome","samplesize.exposure","se.exposure","pos.exposure","chr.exposure","pval.exposure","id.exposure","exposure","mr_keep.exposure","pval_origin.exposure","data_source.exposure","action","mr_keep","samplesize.outcome"]
["Liver cirrhosis","prot-a-896","Calcium uptake protein 3, mitochondrial（MICU1）","rs111476850","A","G","A","G",-0.2543,-0.0238469,0.06217,0.0815338,false,false,false,"6DthrG",7,54008844,0.566738,0.0416276,"outcome",true,"reported","textfile",3301,0.0519,54076537,7,{"v":9.33254e-07,"d":"9.33E-07"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,true,"NA"]
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[{"$nulls":3},"rs355936","C","T","C","T",0.2237,0.0153507,0.0702,0.0939142,false,false,false,"6DthrG",16,66607215,0.693685,0.0389749,"outcome",true,"reported","textfile",3301,0.0486,66641118,16,{"v":4.2658e-06,"d":"4.27E-06"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs4527404","C","G","C","G",0.1244,0.00179155,0.40559,0.426553,false,true,true,"6DthrG",3,22004246,0.937699,0.0229211,"outcome",true,"reported","textfile",3301,0.0257,22045738,3,{"v":1.25893e-06,"d":"1.26E-06"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,false,"NA"]
[{"$nulls":3},"rs62336604","G","A","G","A",-0.1953,-0.033908,0.09655,0.0543781,false,false,false,"6DthrG",4,183157076,0.499843,0.0502537,"outcome",true,"reported","textfile",3301,0.0426,184078229,4,{"v":4.46684e-06,"d":"4.47E-06"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs6830019","T","A","T","A",0.3539,-0.0649154,0.03037,0.0199027,false,true,false,"6DthrG",4,3082156,0.425882,0.0815256,"outcome",true,"reported","textfile",3301,0.071,3083883,4,{"v":6.16595e-07,"d":"6.17E-07"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs7221257","A","G","A","G",0.2378,0.062819,0.06918,0.0586125,false,false,false,"6DthrG",17,6220135,0.194947,0.0484683,"outcome",true,"reported","textfile",3301,0.0512,6123455,17,{"v":3.46737e-06,"d":"3.47E-06"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs78843487","A","C","A","C",-0.2826,-0.00922817,0.04861,0.0260644,false,false,false,"6DthrG",10,4422788,0.896979,0.0712721,"outcome",true,"reported","textfile",3301,0.0595,4464980,10,{"v":2.04174e-06,"d":"2.04E-06"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs79146746","A","G","A","G",0.574,-0.127122,0.01228,0.00984116,false,false,false,"6DthrG",7,31070917,0.273075,0.115986,"outcome",true,"reported","textfile",3301,0.1145,31110532,7,{"v":5.37032e-07,"d":"5.37E-07"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs80331736","G","A","G","A",0.5324,-0.058584,0.01339,0.00853385,false,false,false,"6DthrG",7,144011401,0.637842,0.124456,"outcome",true,"reported","textfile",3301,0.1163,143708494,7,{"v":4.67735e-06,"d":"4.68E-06"},"prot-a-896"," || id:prot-a-896",true,"reported","igd",2,true,"NA"]
[null,"prot-a-2128","Nucleoside diphosphate-linked moiety X motif 8, mitochondrial（NUDT8）","rs10454231","A","G","A","G",0.2016,-0.0298652,0.09784,0.0612649,false,false,false,"dPWbcn",3,59477311,0.529641,0.0475141,"outcome",true,"reported","textfile",3301,0.0422,59463037,3,{"v":1.8197e-06,"d":"1.82E-06"},"prot-a-2128"," || id:prot-a-2128",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs115691841","T","C","T","C",-0.2382,-0.0225007,0.06306,0.0898326,false,false,false,"dPWbcn",4,150824709,0.570853,0.0396981,"outcome",true,"reported","textfile",3301,0.0504,151745861,4,{"v":2.34423e-06,"d":"2.34E-06"},"prot-a-2128"," || id:prot-a-2128",true,"reported","igd",2,true,"NA"]
[{"$nulls":3},"rs11943860","T","G","T","G",-0.1285,0.00355275,0.28591,0.315985,false,false,false,"dPWbcn",4,37989851,0.884318,0.0244179,"outcome",true,"reported","textfile",3301,0.028,37991472,4,{"v":4.57088e-06,"d":"4.57E-06"},"prot-a-2128"," || id:prot-a-2128",true,"reported","igd",2,true,"NA"]
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[{"$nulls":3},"rs77576460","G","C","G","C",0.4477,0.178032,0.01927,0.00894852,false,true,false,"dPWbcn",2,63017084,0.141309,0.121033,"outcome",true,"reported","textfile",3301,0.093,63244219,2,{"v":1.47911e-06,"d":"1.48E-06"},"prot-a-2128"," || id:prot-a-2128",true,"reported","igd",2,true,"NA"]

{"sheet":"Supplementary Table S6","index":5,"n_rows":50,"n_cols":37,"rows_kept":50,"merged":[[3,1,12,1],[3,2,12,2],[13,1,23,1],[13,2,23,2],[24,1,34,1],[24,2,34,2],[35,1,49,1],[35,2,49,2]],"flags":["formulas_cached_only"]}
["Supplementary Table S6.Detailed information on genetic instruments of HCC."]
[]
["outcome","id","protein","SNP","effect_allele.exposure","other_allele.exposure","effect_allele.outcome","other_allele.outcome","beta.exposure","beta.outcome","eaf.exposure","eaf.outcome","remove","palindromic","ambiguous","id.outcome","chr.outcome","pos.outcome","pval.outcome","se.outcome","outcome","mr_keep.outcome","pval_origin.outcome","data_source.outcome","se.exposure","chr.exposure","pos.exposure","pval.exposure","samplesize.exposure","id.exposure","exposure","mr_keep.exposure","pval_origin.exposure","data_source.exposure","action","mr_keep","samplesize.outcome"]
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{"sheet":"Supplementary Table S7","index":6,"n_rows":6,"n_cols":6,"rows_kept":6,"flags":["formulas_cached_only"]}
["Supplementary Table S7.Multivariable MR analysis between MRPs and NAFLD."]
[]
["id","exposure   ","SNP (N)","Beta ","SE ","Pval"]
["prot-a-1055","MRPL33",1,-0.000935954907696073,0.219423672801446,0.996596621976309]
["prot-a-1942","MRPL34",2,0.0456490192515756,0.0750914141766256,0.5432454209309]
["prot-a-1943","FARS2",1,-0.207457298241943,0.332896777596862,0.533160944612417]

{"sheet":"Supplementary Table S8","index":7,"n_rows":6,"n_cols":7,"rows_kept":6,"flags":["formulas_cached_only"]}
["Supplementary Table S8.Results of the inverse causal association between MRPs and liver cirrhosis."]
[]
["expourse","outcome(protein)","id","SNP (N)","Beta ","SE ","P "]
["Liver cirrhosis","GRPEL1","prot-a-1281",18,0.120477891422702,0.0423203647413398,0.00441601891000408]
["Liver cirrhosis","HMCSD","prot-a-1356",18,0.0828524802056577,0.0399943580837034,0.0383023678732493]
["Liver cirrhosis","GLRX2","prot-a-1220",18,0.0931770712436677,0.0447070249361413,0.0371446433365139]

{"sheet":"Supplementary Table S9","index":8,"n_rows":23,"n_cols":1,"rows_kept":23,"flags":["formulas_cached_only"]}
["Supplementary Table S9.20 target proteins for the PPI network."]
[]
["proteins"]
["MRPL33"]
["MRPL34"]
["FARS2"]
["MPC1"]
["SNX8"]
["MTORC1"]
["WDR6"]
["LPL"]
["SWAP70"]
["THBS1"]
["LDLR"]
["HMGCR"]
["NPC1L1"]
["PCSK9"]
["APOB"]
["ABCG5"]
["ABCG8"]
["PPARA"]
["ANGPTL3"]
["APOC3"]