{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["Table 1","Table 2","Table 3","Table 4"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table 1","index":0,"n_rows":8,"n_cols":7,"rows_kept":8,"merged":[[6,0,6,6],[7,0,7,6]],"flags":["formulas_cached_only"]}
["  ","Category","Dataset","SNPs","Sample size","Sex","Population"]
["Female infertility_1","anovulation origin","finn-b-N14_FIANOV",{"v":16379640,"d":"16,379,640"},{"v":119206,"d":"119,206"},"Female","European"]
["Female infertility_2","tubal origin","finn-b-N14_FITUB",{"v":16379641,"d":"16,379,641"},{"v":118644,"d":"118,644"},"Female","European"]
["Female infertility_3","other origin","finn-b-N14_FIOTHNAS",{"v":16379757,"d":"16,379,757"},{"v":128432,"d":"128,432"},"Female","European"]
["Male infertility","Male origin","finn-b-N14_MALEINFERT",{"v":16377329,"d":"16,377,329"},{"v":74159,"d":"74,159"},"Male","European"]
["Telomere length","Aging","ieu-b-4879",{"v":20134421,"d":"20,134,421"},{"v":472174,"d":"472,174"},"Male and female","European"]
["Table 1: Internal detail informations of the GWAS datasets in the text."]
["GWAS, genome-wide association study; SNPs, single‐nucleotide polymorphisms"]

{"sheet":"Table 2","index":1,"n_rows":25,"n_cols":8,"rows_kept":25,"merged":[[0,0,1,0],[0,1,1,1],[0,2,1,2],[0,3,1,3],[0,4,1,4],[0,5,1,5],[0,6,1,6],[0,7,1,7],[23,0,23,6],[24,0,24,6]],"flags":["formulas_cached_only"]}
["Exposure","Outcome","Method","nsnp","OR","Or_lci95","Or_uci95","P-value"]
[]
["Telomere length","Female infertility_1","MR-Egger",137,{"v":1.3265414271365,"d":"1.33"},{"v":0.733843502865678,"d":"0.73"},{"v":2.39793927593228,"d":"2.40"},{"v":0.351202067810153,"d":"0.35"}]
[null,null,"Weighted median",137,{"v":1.02288140892695,"d":"1.02"},{"v":0.602715729302948,"d":"0.60"},{"v":1.73595332900706,"d":"1.74"},{"v":0.933189039221806,"d":"0.93"}]
[null,null,"IVW*",137,{"v":0.927249143206741,"d":"0.93"},{"v":0.664879206636757,"d":"0.66"},{"v":1.29315365106216,"d":"1.29"},{"v":0.65625429748074,"d":"0.66"}]
[null,null,"Simple mode",137,{"v":0.477368093290057,"d":"0.48"},{"v":0.176932742448032,"d":"0.18"},{"v":1.28794870490586,"d":"1.29"},{"v":0.146518944671519,"d":"0.15"}]
[null,null,"Weighted mode",137,{"v":1.06653066374397,"d":"1.07"},{"v":0.557714694231986,"d":"0.56"},{"v":2.03955116920947,"d":"2.04"},{"v":0.845896766906516,"d":"0.85"}]
["Telomere length","Female infertility_2","MR-Egger",137,{"v":1.24658166239318,"d":"1.25"},{"v":0.594180703960232,"d":"0.59"},{"v":2.61530849227805,"d":"2.62"},{"v":0.560861810572948,"d":"0.56"}]
[null,null,"Weighted median",137,{"v":1.63374374433486,"d":"1.63"},{"v":0.847860355649218,"d":"0.85"},{"v":3.14806395224071,"d":"3.15"},{"v":0.142422404002111,"d":"0.14"}]
[null,null,"IVW*",137,{"v":1.12619259567406,"d":"1.13"},{"v":0.744209064653941,"d":"0.74"},{"v":1.70423853025876,"d":"1.70"},{"v":0.573937767041808,"d":"0.57"}]
[null,null,"Simple mode",137,{"v":2.35371497117689,"d":"2.35"},{"v":0.572430137901789,"d":"0.57"},{"v":9.67799177354407,"d":"9.68"},{"v":0.237436233864431,"d":"0.24"}]
[null,null,"Weighted mode",137,{"v":1.75939525201512,"d":"1.76"},{"v":0.756946382390837,"d":"0.76"},{"v":4.08941997058789,"d":"4.09"},{"v":0.191428384129472,"d":"0.19"}]
["Telomere length","Female infertility_3","MR-Egger",137,{"v":1.26346093183348,"d":"1.26"},{"v":0.972500509976977,"d":"0.97"},{"v":1.64147320221695,"d":"1.64"},{"v":0.0821845295663415,"d":"0.08"}]
[null,null,"Weighted median",137,{"v":1.11429965001942,"d":"1.11"},{"v":0.879780738202506,"d":"0.88"},{"v":1.41133313803877,"d":"1.41"},{"v":0.369370651538339,"d":"0.37"}]
[null,null,"IVW*",137,{"v":1.0821463807099,"d":"1.08"},{"v":0.934303896820767,"d":"0.93"},{"v":1.25338317999993,"d":"1.25"},{"v":0.292186961511057,"d":"0.29"}]
[null,null,"Simple mode",137,{"v":0.763226503036047,"d":"0.76"},{"v":0.485091004962212,"d":"0.49"},{"v":1.20083590290859,"d":"1.20"},{"v":0.24464293210436,"d":"0.24"}]
[null,null,"Weighted mode",137,{"v":1.0789073741261,"d":"1.08"},{"v":0.835867103578432,"d":"0.84"},{"v":1.39261506639069,"d":"1.39"},{"v":0.560706183239495,"d":"0.56"}]
["Telomere length","Male infertility","MR-Egger",137,{"v":1.35388952476355,"d":"1.35"},{"v":0.65057995467053,"d":"0.65"},{"v":2.81751202462542,"d":"2.82"},{"v":0.419196056866354,"d":"0.42"}]
[null,null,"Weighted median",137,{"v":1.03751491699936,"d":"1.04"},{"v":0.522232573537928,"d":"0.52"},{"v":2.06122187228525,"d":"2.06"},{"v":0.916255416002734,"d":"0.92"}]
[null,null,"IVW*",137,{"v":1.2559397756797,"d":"1.26"},{"v":0.831554601189183,"d":"0.83"},{"v":1.8969105791473,"d":"1.90"},{"v":0.278715843777275,"d":"0.28"}]
[null,null,"Simple mode",137,{"v":0.451212541671395,"d":"0.45"},{"v":0.117394136768632,"d":"0.12"},{"v":1.73426683278752,"d":"1.73"},{"v":0.248691903687548,"d":"0.25"}]
[null,null,"Weighted mode",137,{"v":1.3854985956226,"d":"1.39"},{"v":0.638448923215077,"d":"0.64"},{"v":3.00667177697712,"d":"3.01"},{"v":0.41089701876942,"d":"0.41"}]
[]
["Table 2: Genetically predicted telomere length and its association with four infertility group by using 137 instrumental variables"]
["MR, Mendelian randomization; IVW, inverse-variance weighted; MR-Egger, Mendelian randomization Egger."]

{"sheet":"Table 3","index":2,"n_rows":8,"n_cols":7,"rows_kept":8,"merged":[[0,0,1,0],[0,1,1,1],[0,2,0,4],[0,5,0,6],[7,0,7,6],[24,1,24,3]],"flags":["formulas_cached_only"]}
["Exposure","Outcome","MR-Egger intercept test",null,null,"MR-PRESSO global test"]
[null,null,"Intercept","Beta(SE)","P-value","RSSobs","P-value"]
["Telomere length","Female infertility_1",-0.0124189972296658,0.00866572982390823,{"v":0.15413644244781,"d":"0.15"},138.531233975935,{"v":0.609,"d":"0.61"}]
["Telomere length","Female infertility_2",-0.00351644294942374,0.0108360927390823,{"v":0.746052669335458,"d":"0.75"},167.648219515174,{"v":0.071,"d":"0.07"}]
["Telomere length","Female infertility_3",-0.00536596408927716,0.0038285357613617,{"v":0.163338310392121,"d":"0.16"},140.462505571372,{"v":0.527,"d":"0.53"}]
["Telomere length","Male infertility",-0.00260642723527106,0.0107285813212497,{"v":0.808418757941238,"d":"0.81"},108.421227401006,{"v":0.983,"d":"0.98"}]
[]
["Table 3: Pleiotropy analysis of the telomere length-related genetic variants by MR-Egger intercept test and MR-PRESSO global test."]

{"sheet":"Table 4","index":3,"n_rows":17,"n_cols":6,"rows_kept":17,"merged":[[16,0,16,6]],"flags":["formulas_cached_only"]}
[]
[]
[]
[]
[]
[]
["Exposure","Outcome","method","Q statistic","Q_df","Q_pval"]
["Telomere length","Female infertility_1","MR-Egger",{"v":126.511230654211,"d":"126.51"},135,{"v":0.686888780707625,"d":"0.69"}]
[null,null,"IVM",{"v":128.565052509772,"d":"128.57"},136,{"v":0.662272609969007,"d":"0.66"}]
["Telomere length","Female infertility_2","MR-Egger",{"v":156.592825213026,"d":"156.59"},135,{"v":0.0985261176721565,"d":"0.10"}]
[null,null,"IVM",{"v":156.714976997653,"d":"156.71"},136,{"v":0.10798154223029,"d":"0.11"}]
["Telomere length","Female infertility_3","MR-Egger",{"v":126.021903655088,"d":"126.02"},135,{"v":0.697833339977992,"d":"0.70"}]
[null,null,"IVM",{"v":127.986304479206,"d":"127.99"},136,{"v":0.675498928335947,"d":"0.68"}]
["Telomere length","Male infertility","MR-Egger",{"v":105.132505917319,"d":"105.13"},135,{"v":0.973248644066245,"d":"0.97"}]
[null,null,"IVM",{"v":105.191526924342,"d":"105.19"},136,{"v":0.976706239218971,"d":"0.98"}]
[]
["Table 4:  Heterogeneity analysis of the telomere length-related genetic variants in the four infertility group GWAS datasets."]