{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Additional file 2 Table S1","Additional file 5 Table S2","Additional file 6 Table S3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Additional file 2 Table S1","index":0,"n_rows":11,"n_cols":7,"rows_kept":11,"merged":[[1,0,2,0],[1,1,2,1],[1,2,1,6]],"flags":["formulas_cached_only"]}
["Additional file 2: Table S1. Parameters of PCA and PLS-DA models based on the date."]
["Figure","Groups","Parameters"]
[null,null,"Model","Type","R2X","R2Y","Q2"]
["Fig 3 A","QC-C0-R4-R8","ESI+","PCA",0.577,null,0.0513]
["Fig 3 B","QC-C0-R4-R8","ESI–","PCA",0.405,null,0.0668]
["Fig 4 A","QC-C0-R4-R8","ESI+","PLS-DA",0.567,0.97,0.814]
["Fig 4 B","QC-C0-R4-R8","ESI–","PLS-DA",0.608,0.978,0.747]
["Fig 5 A","C0-R4","ESI+","PCA",0.556,null,-0.0517]
["Fig 5 B","C0-R8","ESI+","PCA",0.589,null,-0.0192]
["Fig S1 A","C0-R4","ESI–","PCA",0.464,null,0.121]
["Fig S1 B","C0-R8","ESI–","PCA",0.517,null,0.0936]

{"sheet":"Additional file 5 Table S2","index":1,"n_rows":156,"n_cols":16,"rows_kept":156,"merged":[[1,1,1,8],[1,9,1,17]],"flags":["formulas_cached_only"]}
["Additional file 5: Table S2. List of metabolites identified in throughout the entire infection process."]
[null,"POS Models",{"$nulls":7},"NEG Models"]
["infection time","Metabolites","VIP","FC","q-value","m/z","rt(s)",null,null,"infection time","Metabolites","VIP","FC","q-value","m/z","rt(s)"]
["4w","Uracil",1.45277,0.6942134418025468,6.72577222154196e-05,113.0346,145.483,null,null,"4w","Xanthosine",2.58849,0.768426402830338,0.000116928678458684,283.06671,373.7045]
[null,"Indole-2-carboxylic acid",1.28821,2.3615837885374096,9.584295568568705e-05,162.05468,43.995,{"$nulls":3},"pregnenolone sulfate",4.64259,0.435465252706569,0.000321747466477809,395.18541,40.112]
[null,"All-trans-retinoic acid (Vitamin A acid)",2.91149,0.5918387649443286,0.00017008464508217586,301.21597,74.888,{"$nulls":3},"D-Glucuronate",1.10842,0.771481232298243,0.000923547126705857,193.03549,692.62]
[null,"Hydroxyproline",2.27718,0.40605857573840914,0.0009622040390812343,114.05506,453.669,{"$nulls":3},"D-gluconate",2.84971,0.73980034440665,0.00138700491029353,195.05121,635.8795]
[null,"Anthranilic acid (Vitamin L1)",4.95363,0.7963144695201283,0.0013044600461604371,138.05511,495.334,{"$nulls":3},"ketoisocaproic acid",2.73837,0.607864454301605,0.00148827054631188,129.05722,76.208]
[null,"Deoxyadenosine",1.12288,0.7436789031258751,0.0014984887323835725,252.10861,241.029,{"$nulls":3},"Xylitol",1.10948,0.706795285273977,0.00299981316160694,151.06225,419.3615]
[null,"Val-Ile",1.15501,1.608381899810396,0.0015613501104000196,231.1699,335.424,{"$nulls":3},"Alpha-D-Glucose",2.46119,0.710599293991887,0.00303460837778235,179.05654,493.179]
[null,"Isopentenyladenosine",1.88373,0.48750705662177285,0.0018641550788318993,336.16645,107.672,{"$nulls":3},"D-Ribose",1.67129,0.480478506664821,0.00350470293118671,209.06646,501.277]
[null,"Palmitoyl ethanolamide",1.07834,0.7856409347365892,0.0019400643399182522,300.28937,59.177,{"$nulls":3},"all cis-(6,9,12)-Linolenic acid",5.28758,0.834327199829172,0.00442142526093148,277.21575,70.6825]
[null,"1-Stearoyl-sn-glycerol 3-phosphocholine",6.41949,0.7655343255072703,0.002042777440314378,546.35104,318.84,{"$nulls":3},"alpha-Ketocaproic acid",3.03901,0.617075019900944,0.0066960519818433,129.05719,91.633]
[null,"Xanthosine",1.33882,0.7905624166693687,0.0023213487549566337,285.0829,373.538,{"$nulls":3},"Capric acid",2.23532,1.52673089108478,0.0101922167281878,171.13938,77.042]
[null,"7-Oxocholesterol",1.67515,0.690414822292051,0.002388599839216911,401.34155,55.114,{"$nulls":3},"Pantetheine",1.18415,0.750849186823161,0.0109479203472457,277.12081,67.913]
[null,"15-Deoxy-delta-12,14-PGJ2",1.4479,0.6321300756964731,0.002475521056681958,317.21111,196.3695,{"$nulls":3},"Glycocholic acid",2.04751,0.473268725284972,0.0128552570589158,464.29561,447.926]
[null,"Trimethylamine N-oxide",1.21314,0.5287590689561085,0.0026301992991391307,76.07674,576.994,{"$nulls":3},"Indoxyl sulfate",3.81981,0.645278052395383,0.0244369398488176,212.00212,40.702]
[null,"Choline",9.16767,1.450231162092905,0.0026732709445116804,104.1074,474.993,{"$nulls":3},"Taurochenodeoxycholate",10.5615,0.694679579131851,0.0257826869245682,498.28351,194.676]
[null,"S-Methyl-5'-thioadenosine",13.8546,0.6297874843443932,0.004838671036693709,298.09698,169.444,{"$nulls":3},"Glycochenodeoxycholate",5.84669,0.433200774476876,0.0265315925004325,448.3015,353.424]
[null,"L-Pipecolic acid",1.49732,1.8299359470126846,0.006079129897935682,130.08613,537.962,{"$nulls":3},"Tetrahydrocorticosterone",3.7516,0.769389583191098,0.0276575335593377,349.23514,231.8655]
[null,"Acetylcholine",3.58849,1.1244545644298045,0.006758038976693844,146.11758,673.384,{"$nulls":3},"Glycolithocholic acid",1.62636,0.397282541676133,0.029357616479659,432.30655,275.6335]
[null,"all cis-(6,9,12)-Linolenic acid",2.73225,0.7586125605511185,0.00944874311344314,279.2317,75.672,{"$nulls":3},"Linoleic acid",10.611,0.935948241272775,0.0333583818171553,279.23162,70.669]
[null,"N-Oleoylglycine",1.03391,0.5345106519677361,0.011692669701653972,340.28424,174.299,{"$nulls":3},"Maltotriose",5.7871,0.771114882871992,0.0350938670601791,503.15516,823.7565]
[null,"Maltotriose",1.16709,0.8641261463815306,0.012610537334279665,487.1658,912.756,{"$nulls":3},"Uracil",1.59678,0.709515979772467,0.036689401820742,111.02188,172.7375]
[null,"L-Glutamine",1.68907,1.4323309763100172,0.01626819133316621,147.0762,710.1265,{"$nulls":3},"2-Methyl-3-hydroxybutyric acid",1.03138,1.47017048882649,0.0384778610364442,117.05744,238.353]
[null,"Isomaltose",1.34348,0.5731419696101969,0.01726419907861425,325.11311,745.124,{"$nulls":3},"Phosphorylcholine",2.62893,1.35296407056325,0.038856593440306,242.07898,884.096]
[null,"Adenine",1.65515,0.7467290270841739,0.017993732259109538,136.06142,168.762,{"$nulls":3},"2-Oxoadipic acid",5.30564,1.03800482021589,0.0411000140178572,141.01892,627.455]
[null,"Stachyose",1.21213,0.8859148710267725,0.01952029585951335,649.21823,912.996,{"$nulls":3},"S-Methyl-5'-thioadenosine",1.34303,0.772696262670575,0.0411222545741145,356.09951,170.7575]
[null,"His-Ile",1.03143,1.396591727422391,0.026368031479347003,269.16075,514.977,{"$nulls":3},"Myristic acid",5.35593,1.14497418843467,0.0482463272213709,227.20097,73.894]
[null,"Nicotinamide",1.04967,0.906432755887826,0.02868460188267404,123.05533,668.076,{"$nulls":3},"1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine",2.041,0.861723575720491,0.0490349290820834,452.27242,337.7125]
[null,"Cytosine",1.95201,0.8780080162083828,0.028896604178620562,112.05077,411.379,{"$nulls":3},"L-Arabinose",2.65065,1.72485753723093,0.0493855915625585,149.0464,173.972]
[null,"Argininosuccinic acid",1.43032,1.2908014146215965,0.029349786375058997,291.12951,850.626,{"$nulls":3},"Palmitic acid",8.87217,0.944395029066891,0.0596468933265342,255.23199,72.5985]
[null,"Glycolithocholic acid",1.14081,0.3825222692895877,0.03086154122981864,434.32651,275.6805,{"$nulls":3},"Inosine",4.64431,1.00655808734921,0.950448406932126,267.07229,369.8915]
[null,"L-Histidine",3.93739,0.7718875426699552,0.03286821548934399,156.07669,676.634,{"$nulls":3},"Adenine",1.2396,0.820534525843386,0.065697889798397,134.04843,170.759]
[null,"Linoleoyl ethanolamide",1.06276,0.7789198951343214,0.03693722389300621,324.28965,58.517,{"$nulls":3},"Taurolithocholic acid",1.47033,0.541106156494129,0.0676614815883744,482.2882,372.328]
[null,"Ile-Ala",2.03177,1.4115744106675527,0.037034449494918194,203.13847,74.379,{"$nulls":3},"Purine",1.14692,0.787806468941472,0.0687031867501614,119.03781,192.5005]
[null,"L-Leucine",5.00514,0.807497316844382,0.03835615379308912,132.10188,450.5,{"$nulls":3},"Oleic acid",1.28932,0.731918511625576,0.0708344551711537,281.24668,154.497]
[null,"Adenosine",2.60648,0.29419581764129726,0.0405815644407602,250.09254,210.36,{"$nulls":3},"3-Methoxy-4-Hydroxyphenylglycol Sulfate",1.40877,1.29334180582242,0.0719706796714083,263.02151,62.245]
[null,"Glycocholic acid",1.93696,0.475427121153832,0.0106171563225371,430.2952,402.612,{"$nulls":3},"Taurocholate",10.1391,1.37020181856071,0.0729707265232168,514.27793,337.113]
[null,"Glycochenodeoxycholate",3.22985,0.5185809129540059,0.04450807796310802,450.32166,352.9275,{"$nulls":3},"Dodecanoic acid",3.0841,1.30990204644437,0.0747704381202445,199.17031,75.215]
[null,"Val-Ala",1.539,1.4185915607205737,0.044672185089833616,189.1228,77.112,{"$nulls":3},"Thymidine",1.65801,0.87395479170925,0.0857881605332991,241.08194,170.596]
[null,"Maltopentaose",2.6281,0.836642430121659,0.047266974556127876,846.30927,950.648,{"$nulls":3},"Eicosapentaenoic acid",1.99045,0.895705351,0.3889767,301.21503,69.3715]
[null,"sn-Glycerol 3-phosphoethanolamine",3.23237,1.2549811621237434,0.04867120441877194,216.06299,707.431,{"$nulls":3},"L-Valine",1.30001,1.07556029308927,0.0938190788410202,116.07379,521.6175]
[null,"Taurocholate",3.00319,1.457215846678911,0.049301322511898046,498.28859,337.003,null,null,"8w","all cis-(6,9,12)-Linolenic acid",8.92907,0.67147250294576,1.30631462596924e-07,277.21575,70.6825]
[null,"Eicosapentaenoic acid",2.90576,1.3171965848046105,0.049312589575689646,303.23164,75.186,{"$nulls":3},"Glycitein",1.94002,2.7074489595155,7.99949071803619e-07,283.05909,75.0875]
[null,"3.alpha.-Mannobiose",1.30754,0.72825634124924,0.04993625817850356,343.12369,821.54,{"$nulls":3},"Adenosine",1.48041,0.342955274057449,2.72324062350922e-06,326.10743,288.154]
[null,"Phosphorylcholine",2.88771,1.6348837117427808,0.050608217753412385,184.07319,990.768,{"$nulls":3},"pregnenolone sulfate",4.91205,0.368418481892319,4.90002790230655e-06,395.18541,40.112]
[null,"L-Pyroglutamic acid",1.64076,0.8556528583707588,0.051644534714851274,130.04991,710.196,{"$nulls":3},"Taurocholate",11.227,0.619422112229029,1.8004291806309e-05,514.27634,289.064]
[null,"1-Oleoyl-sn-glycero-3-phosphocholine",2.36829,0.7845973776333338,0.05241034737244412,544.33996,337.592,{"$nulls":3},"Thymine",1.64438,0.588374592280579,2.54884293483972e-05,125.03737,126.283]
[null,"L-Glutamate",2.95555,0.8286967003172008,0.052820657706557826,148.06034,710.224,{"$nulls":3},"Linoleic acid",14.4381,0.842850430633364,0.00038510801599269,279.23162,70.669]
[null,"Ribothymidine",1.38394,0.799419954672849,0.05508055157717877,259.09238,619.512,{"$nulls":3},"Hypoxanthine",5.43223,0.872806273943083,0.00049420113008851,135.03335,282.4155]
[null,"Creatinine",4.76574,1.1950776372025218,0.05525959384361664,114.06633,283.068,{"$nulls":3},"D-gluconate",2.58154,0.757147079086517,0.000513459075680937,195.05121,635.8795]
[null,"1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine",1.89724,0.6213791789666572,0.05613011930966227,524.36996,434.0715,{"$nulls":3},"Eicosapentaenoic acid",5.22078,0.783592053118879,0.000915526842039055,301.21503,69.3715]
[null,"Glycerophosphocholine",16.295,1.2623946892017588,0.05944315058674621,258.11021,694.726,{"$nulls":3},"S-Methyl-5'-thioadenosine",1.61757,0.703216458333796,0.00136209836805225,356.09951,170.7575]
[null,"Betaine aldehyde",1.91887,1.38782894271772,0.06071293647090059,102.09178,667.174,{"$nulls":3},"Alpha-D-Glucose",2.61295,0.628709688458576,0.00233932437409527,179.05654,493.179]
[null,"Taurine",5.26206,1.3618214754495344,0.06073351703351809,126.02206,511.665,{"$nulls":3},"Pantetheine",1.49072,0.646251192083048,0.00400217232106354,277.12081,67.913]
[null,"L-Carnitine",5.33999,0.8320648329930921,0.06140911566729987,162.11249,623.447,{"$nulls":3},"Hippuric acid",1.30998,1.33737225198034,0.00454286870298418,178.05125,316.712]
[null,"L-Phenylalanine",3.9008,1.1296410575212459,0.0614386159596677,166.08596,460.023,{"$nulls":3},"D-Ribose",1.46061,0.516987966832395,0.00465716659193007,209.06646,501.277]
[null,"Inosine",1.54859,1.3374673306952738,0.06168515779626985,251.07703,215.434,{"$nulls":3},"Thymidine",2.97509,0.720236950164842,0.00486640688140855,241.08194,170.596]
[null,"Betaine",3.08658,0.8133992006483995,0.06268582785298771,118.0865,502.7005,{"$nulls":3},"Arachidonic Acid (peroxide free)",27.6432,1.30486717538694,0.00965523083335974,303.23089,66.7935]
[null,"Cytidine",1.71513,0.9086576366281729,0.08211354782875258,244.09263,411.319,{"$nulls":3},"2'-Deoxyuridine",1.78067,0.58311149912006,0.0102942756778131,227.06656,193.141]
[null,"1-Palmitoyl-sn-glycero-3-phosphocholine",2.39822,0.8122292215319669,0.08358986067264858,518.32373,312.99,{"$nulls":3},"Cholic acid",1.78615,0.515330400680039,0.021269531869813,407.27572,328.511]
[null,"trans-2-Hydroxycinnamic acid",1.58318,1.170485847978976,0.08660065639080533,165.05428,535.4995,{"$nulls":3},"Chenodeoxycholate",1.83836,0.354469757369431,0.0232096618126439,391.28083,284.346]
[null,"D-Alanyl-D-alanine (D-Ala-D-Ala)",1.26893,1.597458845573088,0.08849074359194017,161.09138,113.401,{"$nulls":3},"Pantothenate",1.46741,0.924326744455445,0.0329256657371885,218.10343,473.8585]
[null,"Dopamine",1.19229,1.1563217943051634,0.09036023245329589,136.07539,535.518,{"$nulls":3},"Uracil",1.71356,0.673958683637758,0.0346525980204334,111.02188,172.7375]
[null,"Purine",1.51952,0.733492862252123,0.09119589156731654,121.05081,192.0145,{"$nulls":3},"Inosine",4.0962,0.867962181187436,0.0413180002247332,267.07229,369.8915]
[null,"1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine (SOPC)",9.14178,0.8182264229284493,0.09293625335351251,854.57027,211.545,{"$nulls":3},"L-Glutamate",1.76597,0.888630441476464,0.0425745201217621,146.04738,710.008]
[null,"Tyramine",3.05425,1.1811441126259623,0.09600823002979293,120.08074,460.126,{"$nulls":3},"Capric acid",1.799,1.47365841200473,0.0432116758512554,171.13938,77.042]
[null,"Ser-Ala",1.26422,1.719920720655973,0.09828729725091682,177.08652,143.75,{"$nulls":3},"Myristic acid",5.47587,1.15627058172379,0.0437282647895211,227.20097,73.894]
["8w","Pro-Thr",1.01453,0.4582963874118836,2.3268054685438087e-08,217.11787,506.41,{"$nulls":3},"sn-Glycerol 3-phosphoethanolamine",2.90095,1.1463013118334,0.0443853436958982,214.04851,706.3005]
[null,"Daidzein",9.81888,2.732459769293522,1.9384412547294148e-07,255.06492,76.146,{"$nulls":3},"Adenine",1.2766,0.813625403945287,0.046689151248143,134.04843,170.759]
[null,"Deoxyadenosine",1.27625,0.589838845102152,6.766460839639366e-07,252.10861,241.029,{"$nulls":3},"Phenylpyruvate",1.36268,0.58331840369149,0.0516802787818379,163.04062,173.1275]
[null,"Indole-2-carboxylic acid",1.0913,2.2212427336314984,1.6352229123908506e-06,162.05468,43.995,{"$nulls":3},"Cytidine",1.38684,0.904035762866355,0.051843922959056,242.0774,411.6325]
[null,"5-Methylcytosine",1.25263,0.7079133955478122,3.172223873206142e-06,126.06597,333.7515,{"$nulls":3},"ketoisocaproic acid",2.38914,0.673007888348512,0.0535898460263691,129.05722,76.208]
[null,"Glycitein",4.19681,3.0724583849324874,1.8363327692808164e-05,285.07557,75.649,{"$nulls":3},"Glycocholic acid",3.26466,0.605635235195063,0.0571527094997511,464.29549,403.078]
[null,"Palmitoyl ethanolamide",1.39096,0.6571678612742393,1.90762153675882e-05,300.28937,59.177,{"$nulls":3},"L-Histidine",1.1281,0.693863977887717,0.0639059507858844,154.06335,979.842]
[null,"Adenosine",4.6084,0.77670321407786,4.876510933985389e-05,268.10398,286.812,{"$nulls":3},"Prostaglandin E2",1.24923,1.45299801016322,0.0684030807600061,351.21442,131.543]
[null,"Genistein",5.76525,4.752624867042258,5.272389894666971e-05,271.05964,67.105,{"$nulls":3},"2-Oxoadipic acid",4.57873,1.04383280150621,0.0767763517898383,141.01892,627.455]
[null,"Uracil",1.10812,0.7058568652101539,7.772060271333305e-05,113.0346,145.483,{"$nulls":3},"D-Glucosamine 1-phosphate (Glucosamine-1P)",1.48024,2.36165587704665,0.0793251093243447,258.0371,749.5215]
[null,"Deoxycytidine",3.93133,0.8146487347490731,8.153323330119415e-05,455.18891,350.271,{"$nulls":3},"L-Methionine",1.34993,1.09740784562336,0.088448954808143,148.04525,486.933]
[null,"Hydroxyproline",2.20149,0.29350436529948004,0.00014205834021036086,114.05506,453.669,{"$nulls":3},"Taurolithocholic acid",1.58328,0.586425080733508,0.0936231723552161,482.2882,372.328]
[null,"Linoleoyl ethanolamide",1.82477,0.5283364577945522,0.0002943409903183061,324.28965,58.517,{"$nulls":3},"Glycochenodeoxycholate",5.43141,0.57990749075248,0.0997329536356751,448.3015,353.424]
[null,"L-Pipecolic acid",1.29932,1.6822451995674101,0.00035189985580287683,130.08613,537.962]
[null,"Choline",8.87087,1.5402891739690434,0.00035809825561206325,104.1074,474.993]
[null,"Linoleic acid",1.01727,0.4715662230562867,0.00039140404741362184,263.23609,77.373]
[null,"Ile-Ala",2.73358,1.8357716283332968,0.0006958817043363548,203.13847,74.379]
[null,"Cytosine",2.00943,0.8221309811873966,0.0007339334300647108,112.05077,411.379]
[null,"S-Methyl-5'-thioadenosine",13.869,0.5607653058085549,0.000818364464712038,298.09698,169.444]
[null,"1-Palmitoyl-sn-glycero-3-phosphocholine",2.8002,0.7027757104756907,0.000980635557821345,518.32373,312.99]
[null,"N1-Methyl-2-pyridone-5-carboxamide",1.25976,0.5805902260816264,0.0011922555298362523,153.0654,138.1445]
[null,"7-Oxocholesterol",1.66313,0.625816249748649,0.0013680471424729265,401.34155,55.114]
[null,"Cytidine",2.34934,0.8511886266874905,0.0015660421316985172,244.09263,411.319]
[null,"Cyclohexylamine",2.47225,0.6138046254345197,0.0016919164547912298,160.13299,688.692]
[null,"Betaine",2.73199,0.7579280598878956,0.002032763591133261,118.0865,502.7005]
[null,"Xanthosine",1.75938,1.1746702486648313,0.0028663104333323444,285.08304,542.779]
[null,"Adenosine 3'-monophosphate",1.4172,0.8572937190319734,0.003238929128736208,348.07081,723.623]
[null,"L-Glutamine",1.63725,1.5836575783746052,0.00400180680568339,147.0762,710.1265]
[null,"Ile-Gly",1.02406,2.20783103981528,0.004245511962099272,189.12295,453.989]
[null,"Isopentenyladenosine",1.36514,0.5475866353580051,0.005167745547795822,336.16645,107.672]
[null,"Allopurinol riboside",2.08396,0.7480803024010568,0.005305221451660721,537.1688,369.361]
[null,"Phe-Ala",1.38852,2.053170117789597,0.005382460006651313,237.12267,67.83]
[null,"Glycerophosphocholine",19.7846,1.4654030711493966,0.005736651227670363,258.11021,694.726]
[null,"Gly-Leu",1.04401,1.6379901482116175,0.006223292886003734,189.12301,493.5675]
[null,"Pro-Ala",1.63917,1.5949822160081484,0.006505673827627355,187.10724,131.45]
[null,"PC(16:0/16:0)",8.96511,0.6092529076542589,0.006968691614056776,756.55367,237.182]
[null,"sn-Glycerol 3-phosphoethanolamine",3.52469,1.3882543929152213,0.00868219945125791,216.06299,707.431]
[null,"Nicotinamide",1.11948,0.950688639891066,0.370476240160297,123.05533,668.076]
[null,"1-Oleoyl-sn-glycero-3-phosphocholine",8.95333,0.7008643287648542,0.008874691240935855,522.35552,321.9175]
[null,"D-Alanyl-D-alanine (D-Ala-D-Ala)",1.91765,2.645655563920528,0.009545442223534387,161.09138,113.401]
[null,"all cis-(6,9,12)-Linolenic acid",2.10974,0.773842006121534,0.00971166935548254,279.2317,75.672]
[null,"Prostaglandin D2(PGD2)",1.66537,1.8069138296447667,0.00997937850443903,335.2218,194.186]
[null,"Prostaglandin B1",1.48454,1.4178018785964321,0.010237521834501195,337.23735,293.9225]
[null,"Anthranilic acid (Vitamin L1)",3.12278,0.8589575579929841,0.012929772255793144,138.05511,495.334]
[null,"Hypoxanthine",3.16153,0.8420181836583153,0.013964490845464162,137.0459,369.352]
[null,"All-trans-retinoic acid (Vitamin A acid)",1.66843,0.7315408846812623,0.016019381626770503,301.21597,74.888]
[null,"Phe-Thr",1.08323,2.2496777346534054,0.018442033430832578,267.13375,363.108]
[null,"Dopamine",1.0828,1.1655834438327521,0.01869200302926791,136.07539,535.518]
[null,"trans-2-Hydroxycinnamic acid",1.42731,1.1761542488229,0.021310545332389148,165.05428,535.4995]
[null,"Val-Ile",1.46846,2.2346939185680936,0.0214403698625085,231.1699,335.424]
[null,"Argininosuccinic acid",1.21154,1.2795079926328772,0.02225011844047347,291.12951,850.626]
[null,"L-Tyrosine",2.23642,1.1894342405287142,0.02339861090951274,182.0809,535.687]
[null,"L-Glutamate",2.75952,0.8002160853808283,0.02386499950152768,148.06034,710.224]
[null,"Glycocholic acid",1.36668,0.5147906405773209,0.024010932610892606,430.2952,402.612]
[null,"L-Leucine",4.10908,0.8079647891168762,0.025599824063225935,132.10188,450.5]
[null,"His-Ala",1.17248,1.684791116799771,0.025806094398222037,227.11345,606.2585]
[null,"N-Acetyl-D-glucosamine",1.95261,1.1733563560164433,0.02642059010187205,204.08641,447.085]
[null,"Oxypurinol",1.21847,1.125801871301296,0.028294666563955493,153.0405,542.887]
[null,"Ile-Thr",1.84115,1.798838305490848,0.031218573121006937,233.14957,80.196]
[null,"Arg-Glu",1.36993,2.0339609742504425,0.03187886531158545,304.16159,818.449]
[null,"1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine (SOPC)",5.88988,0.8252757257131761,0.03297757234614926,854.57027,211.545]
[null,"L-Pyroglutamic acid",1.32017,0.848390632174859,0.03506860312795484,130.04991,710.196]
[null,"Arg-Ala",1.40412,1.4115879621854677,0.041111205285092496,246.15597,750.92]
[null,"Arachidonic Acid (peroxide free)",1.21199,1.378349523073032,0.04454475972953486,269.22582,53.71]
[null,"His-Ile",1.37835,1.9340637878975442,0.04513820955551144,269.16075,514.977]
[null,"Val-Ala",2.34642,2.1152455112922075,0.045291101340143414,189.1228,77.112]
[null,"Val-Thr",1.10522,2.0044690191305965,0.046801185014732634,260.16119,115.8]
[null,"D-Mannose",1.16334,0.7079616235726598,0.04893443771908794,198.09682,520.501]
[null,"trans-Vaccenic acid",1.76175,1.5411405639485125,0.05018761861038408,265.25215,56.469]
[null,"Stachyose",1.11433,0.9173407969859636,0.050875017748479,667.22943,911.6505]
[null,"His-Glu",1.11495,1.5402858599272713,0.05205462462938974,285.11941,741.629]
[null,"1,2-dioleoyl-sn-glycero-3-phosphatidylcholine",4.60553,0.8275619931884021,0.06284921453980462,830.56997,219.089]
[null,"20-Hydroxyarachidonic acid",5.13227,1.4848578974951319,0.06461667944361821,362.26936,68.0395]
[null,"Retinene",1.08441,1.320316057338867,0.0720287650730862,285.22123,74.536]
[null,"1-Myristoyl-sn-glycero-3-phosphocholine",2.60475,0.7370684982413509,0.07607578856131733,468.30853,333.867]
[null,"L-Histidine",1.71857,0.7055586154366158,0.07846538961562889,156.07668,812.155]
[null,"Phosphorylcholine",8.84522,0.800706534701725,0.0784660865217777,184.07339,885.9015]
[null,"D-Proline",1.54868,0.908422484935152,0.07848333532637179,116.07094,542.629]
[null,"1-Palmitoylglycerol",1.14462,1.322004869919996,0.08285975352806665,313.27359,254.938]
[null,"Glycochenodeoxycholate",2.0079,0.5224513822103442,0.08553945512951111,432.31102,353.3385]
[null,"Thr-Ala",1.65732,3.1860118971439717,0.08730374662077478,191.10204,108.746]
[null,"NG,NG-dimethyl-L-arginine(ADMA)",1.3692,0.8485087360466692,0.08736393326638765,203.15027,928.838]
[null,"Ser-Ala",2.22565,3.5483128264800823,0.09046452643411243,177.08652,143.75]
[null,"Thr-Thr",1.22909,2.6250873701544335,0.09242842041855229,221.11279,162.099]
[null,"Taurocholate",2.45452,1.391940649,0.024234046,498.28859,337.003]
[null,"Adenine",1.26163,0.813488017895399,0.157564151695311,136.06142,168.762]
[null,"15-Deoxy-delta-12,14-PGJ2",1.249,1.197143992403917,0.09335017619882131,317.21116,98.884]

{"sheet":"Additional file 6 Table S3","index":2,"n_rows":23,"n_cols":7,"rows_kept":23,"flags":["formulas_cached_only"]}
["Additional file 6: Table S3. Summary of the top 10 pathway analysis using MetaboAnalyst during different infection groups."]
["Infection group","Metabolic pathway","Total","Hits","Raw P-value","-log(p)","Impact"]
["4W","Glycerophospholipid metabolism",36,5,0.0035543,5.6396,0.09305]
[null,"Pentose and glucuronate interconversions",18,3,0.014785,4.2141,0.29688]
[null,"Valine, leucine and isoleucine biosynthesis",8,2,0.021724,3.8294,0]
[null,"Primary bile acid biosynthesis",46,4,0.045187,3.097,0.0914]
[null,"Arginine biosynthesis",14,2,0.063041,2.764,0.11675]
[null,"Biosynthesis of unsaturated fatty acids",36,3,0.089246,2.4164,0]
[null,"Pantothenate and CoA biosynthesis",19,2,0.10791,2.2264,0.04286]
[null,"Ether lipid metabolism",20,2,0.1177,2.1396,0.18072]
[null,"beta-Alanine metabolism",21,2,0.12771,2.058,0]
[null,"Pentose phosphate pathway",21,2,0.12771,2.058,0.05183]
["8W","Glycerophospholipid metabolism",36,6,0.0027919,5.881,0.23804]
[null,"Pyrimidine metabolism",39,6,0.0042453,5.4619,0.23377]
[null,"Linoleic acid metabolism",5,2,0.015335,4.1776,1]
[null,"Arginine biosynthesis",14,3,0.017395,4.0516,0.2335]
[null,"Nitrogen metabolism",6,2,0.022397,3.7988,0]
[null,"D-Glutamine and D-glutamate metabolism",6,2,0.022397,3.7988,0.5]
[null,"Pantothenate and CoA biosynthesis",19,3,0.040018,3.2184,0.05]
[null,"Biosynthesis of unsaturated fatty acids",36,4,0.056863,2.8671,0]
[null,"Phenylalanine metabolism",12,2,0.084127,2.4754,0]
[null,"alpha-Linolenic acid metabolism",13,2,0.096863,2.3345,0.33333]
["RT, retention time; m/z, mass-to-charge ratio; VIP, variable importance for projection; FC, Fold change;  "]