{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["Table S1","Table S2","Table S3","Table S4"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table S1","index":0,"n_rows":35,"n_cols":34,"rows_kept":35,"merged":[[0,0,0,11]],"flags":["formulas_cached_only"]}
["Table S1. Matrix of rho values from spearman rank correlation corresponing to Figure 4a."]
[null,"IL-1β","TNFa","Body Weight","Methylguanidine","IFN-γ","Bacterial Load","Carnosine","Deoxyuridine","Glycerophosphocholine","p-Hydroxyphenylacetic-acid","Taurine","L-Allothreonine","Mannitol","N-Acetylgalactosamine","Hypoxanthine","L-Histidine","Creatine","N-Acetyl-L-alanine","3-Methylxanthine","Propionylglycine","N-Acetylneuraminic acid","Betaine","D-Glucuronic acid","7-Methylxanthine","Palmitoylcarnitine","2-Hydroxybutyric acid","Tryptamine","Caffeine","FAD","Dimethylglycine","Putrescine","L-Threonine","Guanidoacetic acid"]
["IL-1β",{"v":1,"d":"1.00"},{"v":0.775980490695951,"d":"0.78"},{"v":0.192379784409469,"d":"0.19"},{"v":0.263372666535847,"d":"0.26"},{"v":0.0992385984878035,"d":"0.10"},{"v":0.215258797446269,"d":"0.22"},{"v":-0.381544621867243,"d":"-0.38"},{"v":-0.461757993569168,"d":"-0.46"},{"v":0.0235268542742646,"d":"0.02"},{"v":-0.0266907955092052,"d":"-0.03"},{"v":-0.131951633295046,"d":"-0.13"},{"v":-0.03781844957575,"d":"-0.04"},{"v":-0.155993644017746,"d":"-0.16"},{"v":-0.0214150435061246,"d":"-0.02"},{"v":-0.358058409181256,"d":"-0.36"},{"v":-0.207220853812573,"d":"-0.21"},{"v":-0.188111380262358,"d":"-0.19"},{"v":0.0272998694072543,"d":"0.03"},{"v":0.141962742533938,"d":"0.14"},{"v":0.0617385780247199,"d":"0.06"},{"v":-0.102712118667134,"d":"-0.10"},{"v":-0.162798255802979,"d":"-0.16"},{"v":-0.101594985762101,"d":"-0.10"},{"v":-0.0576949449888966,"d":"-0.06"},{"v":-0.342240636186163,"d":"-0.34"},{"v":-0.352244079649142,"d":"-0.35"},{"v":-0.116232589285252,"d":"-0.12"},{"v":-0.228008787474529,"d":"-0.23"},{"v":-0.182984535706825,"d":"-0.18"},{"v":0.169576479486383,"d":"0.17"},{"v":-0.195219793917882,"d":"-0.20"},{"v":-0.117360744145935,"d":"-0.12"},{"v":-0.224289529280142,"d":"-0.22"}]
["TNFa",null,{"v":1,"d":"1.00"},{"v":0.0428340597488408,"d":"0.04"},{"v":0.0902767006441299,"d":"0.09"},{"v":0.5563534936813,"d":"0.56"},{"v":0.2546309532693,"d":"0.25"},{"v":-0.532024921463811,"d":"-0.53"},{"v":-0.57983935151619,"d":"-0.58"},{"v":0.188297840154808,"d":"0.19"},{"v":0.219161046684438,"d":"0.22"},{"v":0.0481698078485654,"d":"0.05"},{"v":0.137167187703973,"d":"0.14"},{"v":0.0428878546807361,"d":"0.04"},{"v":0.189831732196086,"d":"0.19"},{"v":-0.109448163623547,"d":"-0.11"},{"v":-0.110078927383702,"d":"-0.11"},{"v":0.0245260668159261,"d":"0.02"},{"v":-0.00266081270181732,"d":"-0.00"},{"v":0.298999852415084,"d":"0.30"},{"v":0.179002668564993,"d":"0.18"},{"v":0.0796463280356737,"d":"0.08"},{"v":0.0253748520104782,"d":"0.03"},{"v":-0.0582300837003803,"d":"-0.06"},{"v":0.00432380109743084,"d":"0.00"},{"v":-0.190564776168702,"d":"-0.19"},{"v":-0.300841018730594,"d":"-0.30"},{"v":-0.0357181135145853,"d":"-0.04"},{"v":-0.119520360395443,"d":"-0.12"},{"v":-0.0916933311547601,"d":"-0.09"},{"v":0.46290031506049,"d":"0.46"},{"v":-0.0215613173248097,"d":"-0.02"},{"v":0.108071616546337,"d":"0.11"},{"v":0.00277119628186954,"d":"0.00"}]
["Body Weight",null,null,{"v":1,"d":"1.00"},{"v":0.962033867510097,"d":"0.96"},{"v":0.28017996477667,"d":"0.28"},{"v":0.499168524545129,"d":"0.50"},{"v":-0.736127354011461,"d":"-0.74"},{"v":-0.743909187818223,"d":"-0.74"},{"v":-0.505066817909247,"d":"-0.51"},{"v":-0.779048710319997,"d":"-0.78"},{"v":-0.92108388484519,"d":"-0.92"},{"v":-0.9232284971975,"d":"-0.92"},{"v":-0.931368978323076,"d":"-0.93"},{"v":-0.869534300748471,"d":"-0.87"},{"v":-0.955241020286405,"d":"-0.96"},{"v":-0.912821940073099,"d":"-0.91"},{"v":-0.848909013949316,"d":"-0.85"},{"v":-0.752184630364763,"d":"-0.75"},{"v":-0.709166529238999,"d":"-0.71"},{"v":-0.827593368326429,"d":"-0.83"},{"v":-0.930251494808484,"d":"-0.93"},{"v":-0.938539762886345,"d":"-0.94"},{"v":-0.9161217018285,"d":"-0.92"},{"v":-0.900876735345827,"d":"-0.90"},{"v":-0.96130868764399,"d":"-0.96"},{"v":-0.909723885764537,"d":"-0.91"},{"v":-0.868679223085568,"d":"-0.87"},{"v":-0.905359677469231,"d":"-0.91"},{"v":-0.918118556376405,"d":"-0.92"},{"v":-0.790778978113171,"d":"-0.79"},{"v":-0.948277802649971,"d":"-0.95"},{"v":-0.928884546311351,"d":"-0.93"},{"v":-0.941095401160313,"d":"-0.94"}]
["Methylguanidine",{"$nulls":3},{"v":1,"d":"1.00"},{"v":0.315154372583697,"d":"0.32"},{"v":0.56869788679726,"d":"0.57"},{"v":-0.758786203610907,"d":"-0.76"},{"v":-0.757369265544668,"d":"-0.76"},{"v":-0.52655742838508,"d":"-0.53"},{"v":-0.829845743902311,"d":"-0.83"},{"v":-0.976324038209894,"d":"-0.98"},{"v":-0.960138568034179,"d":"-0.96"},{"v":-0.967298768457938,"d":"-0.97"},{"v":-0.909326978131071,"d":"-0.91"},{"v":-0.947932313212419,"d":"-0.95"},{"v":-0.910401343073848,"d":"-0.91"},{"v":-0.845954736875458,"d":"-0.85"},{"v":-0.830029570206124,"d":"-0.83"},{"v":-0.781635168010896,"d":"-0.78"},{"v":-0.895684368224947,"d":"-0.90"},{"v":-0.969462039160736,"d":"-0.97"},{"v":-0.983102043649565,"d":"-0.98"},{"v":-0.955481929509956,"d":"-0.96"},{"v":-0.947699031814556,"d":"-0.95"},{"v":-0.978543547886379,"d":"-0.98"},{"v":-0.948460097557327,"d":"-0.95"},{"v":-0.926874163145634,"d":"-0.93"},{"v":-0.936134347076279,"d":"-0.94"},{"v":-0.96454050669705,"d":"-0.96"},{"v":-0.806253281744237,"d":"-0.81"},{"v":-0.970189300474845,"d":"-0.97"},{"v":-0.943570394602109,"d":"-0.94"},{"v":-0.976617603707451,"d":"-0.98"}]
["IFN-γ",{"$nulls":4},{"v":1,"d":"1.00"},{"v":0.535654033343512,"d":"0.54"},{"v":-0.731344129156284,"d":"-0.73"},{"v":-0.668218108216941,"d":"-0.67"},{"v":-0.0443966126167336,"d":"-0.04"},{"v":-0.0792159015876325,"d":"-0.08"},{"v":-0.266766316070775,"d":"-0.27"},{"v":-0.240374341273923,"d":"-0.24"},{"v":-0.228840296509371,"d":"-0.23"},{"v":-0.125927558507028,"d":"-0.13"},{"v":-0.198570633690489,"d":"-0.20"},{"v":-0.357280055516231,"d":"-0.36"},{"v":-0.152763412210054,"d":"-0.15"},{"v":-0.535107095808381,"d":"-0.54"},{"v":-0.109169635196481,"d":"-0.11"},{"v":-0.248996628157295,"d":"-0.25"},{"v":-0.23363520187735,"d":"-0.23"},{"v":-0.275292126083315,"d":"-0.28"},{"v":-0.470647195198122,"d":"-0.47"},{"v":-0.418646582105471,"d":"-0.42"},{"v":-0.378583275731247,"d":"-0.38"},{"v":-0.511050383863027,"d":"-0.51"},{"v":-0.422353390173637,"d":"-0.42"},{"v":-0.379323988070132,"d":"-0.38"},{"v":-0.426289426078002,"d":"-0.43"},{"v":0.0462859760336772,"d":"0.05"},{"v":-0.340251932374509,"d":"-0.34"},{"v":-0.163188036908425,"d":"-0.16"},{"v":-0.200810911726791,"d":"-0.20"}]
["Bacterial Load",{"$nulls":5},{"v":1,"d":"1.00"},{"v":-0.749671574272597,"d":"-0.75"},{"v":-0.677778331599519,"d":"-0.68"},{"v":-0.116964670859072,"d":"-0.12"},{"v":-0.460794190581304,"d":"-0.46"},{"v":-0.584214841989428,"d":"-0.58"},{"v":-0.572042867620034,"d":"-0.57"},{"v":-0.514438637729375,"d":"-0.51"},{"v":-0.504445561212961,"d":"-0.50"},{"v":-0.485502671928448,"d":"-0.49"},{"v":-0.457490385457269,"d":"-0.46"},{"v":-0.441238377000633,"d":"-0.44"},{"v":-0.57816236195098,"d":"-0.58"},{"v":-0.557082559875386,"d":"-0.56"},{"v":-0.57741411091926,"d":"-0.58"},{"v":-0.538021540267035,"d":"-0.54"},{"v":-0.536663036057614,"d":"-0.54"},{"v":-0.68462262947998,"d":"-0.68"},{"v":-0.655435224548108,"d":"-0.66"},{"v":-0.555419225149211,"d":"-0.56"},{"v":-0.636093397505159,"d":"-0.64"},{"v":-0.578822674995576,"d":"-0.58"},{"v":-0.436280161939328,"d":"-0.44"},{"v":-0.548515468933951,"d":"-0.55"},{"v":-0.276381713741251,"d":"-0.28"},{"v":-0.619386262545875,"d":"-0.62"},{"v":-0.383261113927206,"d":"-0.38"},{"v":-0.48493334293046,"d":"-0.48"}]
["Carnosine",{"$nulls":6},{"v":1,"d":"1.00"},{"v":0.987992407389916,"d":"0.99"},{"v":0.0964756175049604,"d":"0.10"},{"v":0.405230097120167,"d":"0.41"},{"v":0.668092725099788,"d":"0.67"},{"v":0.636431413024226,"d":"0.64"},{"v":0.627839132946832,"d":"0.63"},{"v":0.515088851564244,"d":"0.52"},{"v":0.689187999271344,"d":"0.69"},{"v":0.663180844742667,"d":"0.66"},{"v":0.514841338560718,"d":"0.51"},{"v":0.645672703158073,"d":"0.65"},{"v":0.416610933182018,"d":"0.42"},{"v":0.599765292444901,"d":"0.60"},{"v":0.663325067214017,"d":"0.66"},{"v":0.685385990860909,"d":"0.69"},{"v":0.7997865647595,"d":"0.80"},{"v":0.755212639772286,"d":"0.76"},{"v":0.802907455916589,"d":"0.80"},{"v":0.87127866040145,"d":"0.87"},{"v":0.710013138735795,"d":"0.71"},{"v":0.687553369325975,"d":"0.69"},{"v":0.732270095951981,"d":"0.73"},{"v":0.29418843484925,"d":"0.29"},{"v":0.773605464387512,"d":"0.77"},{"v":0.584271189712443,"d":"0.58"},{"v":0.668487107826629,"d":"0.67"}]
["Deoxyuridine",{"$nulls":7},{"v":1,"d":"1.00"},{"v":0.0602238483080806,"d":"0.06"},{"v":0.368638111693814,"d":"0.37"},{"v":0.646195495460672,"d":"0.65"},{"v":0.605918984943347,"d":"0.61"},{"v":0.611061307636799,"d":"0.61"},{"v":0.483902583177273,"d":"0.48"},{"v":0.706918865343475,"d":"0.71"},{"v":0.652130198172607,"d":"0.65"},{"v":0.50283767798121,"d":"0.50"},{"v":0.578016216897885,"d":"0.58"},{"v":0.354135107419331,"d":"0.35"},{"v":0.556776820966097,"d":"0.56"},{"v":0.646978841849015,"d":"0.65"},{"v":0.671811854689793,"d":"0.67"},{"v":0.760600459269193,"d":"0.76"},{"v":0.718482242155509,"d":"0.72"},{"v":0.812060802651983,"d":"0.81"},{"v":0.867504579352985,"d":"0.87"},{"v":0.681492358531132,"d":"0.68"},{"v":0.686331491331016,"d":"0.69"},{"v":0.710273074233666,"d":"0.71"},{"v":0.271291112818081,"d":"0.27"},{"v":0.763433448747777,"d":"0.76"},{"v":0.590412673718828,"d":"0.59"},{"v":0.677963773577909,"d":"0.68"}]
["Glycerophosphocholine",{"$nulls":8},{"v":1,"d":"1.00"},{"v":0.83456297092925,"d":"0.83"},{"v":0.618251204912465,"d":"0.62"},{"v":0.610854122623364,"d":"0.61"},{"v":0.692211568739206,"d":"0.69"},{"v":0.725271212366989,"d":"0.73"},{"v":0.601968589929444,"d":"0.60"},{"v":0.768888057765122,"d":"0.77"},{"v":0.826360547876853,"d":"0.83"},{"v":0.601847749916479,"d":"0.60"},{"v":0.646425759098799,"d":"0.65"},{"v":0.471133203435879,"d":"0.47"},{"v":0.513402060561348,"d":"0.51"},{"v":0.548272320666768,"d":"0.55"},{"v":0.532588751095435,"d":"0.53"},{"v":0.468433413968413,"d":"0.47"},{"v":0.464675595828266,"d":"0.46"},{"v":0.390713518518486,"d":"0.39"},{"v":0.500455570434824,"d":"0.50"},{"v":0.583852078282868,"d":"0.58"},{"v":0.608172747512297,"d":"0.61"},{"v":0.624092488291039,"d":"0.62"},{"v":0.436872193833211,"d":"0.44"},{"v":0.515942598350829,"d":"0.52"},{"v":0.464533513437949,"d":"0.46"}]
["p-Hydroxyphenylacetic acid",{"$nulls":9},{"v":1,"d":"1.00"},{"v":0.911324687059313,"d":"0.91"},{"v":0.910020284780683,"d":"0.91"},{"v":0.921781630987088,"d":"0.92"},{"v":0.966877705200853,"d":"0.97"},{"v":0.824514184897805,"d":"0.82"},{"v":0.871594550987241,"d":"0.87"},{"v":0.944182827518637,"d":"0.94"},{"v":0.759904791569824,"d":"0.76"},{"v":0.917655434319736,"d":"0.92"},{"v":0.820187162037855,"d":"0.82"},{"v":0.832040362758133,"d":"0.83"},{"v":0.840379789294192,"d":"0.84"},{"v":0.832015576964653,"d":"0.83"},{"v":0.789997447002142,"d":"0.79"},{"v":0.735302008764679,"d":"0.74"},{"v":0.66308669614017,"d":"0.66"},{"v":0.747108247918856,"d":"0.75"},{"v":0.746723525482154,"d":"0.75"},{"v":0.820358743465314,"d":"0.82"},{"v":0.833871138306082,"d":"0.83"},{"v":0.779176075169778,"d":"0.78"},{"v":0.775036001265221,"d":"0.78"},{"v":0.790259991755376,"d":"0.79"}]
["Taurine",{"$nulls":10},{"v":1,"d":"1.00"},{"v":0.991174999415798,"d":"0.99"},{"v":0.985527914945812,"d":"0.99"},{"v":0.966516297338457,"d":"0.97"},{"v":0.907604923917849,"d":"0.91"},{"v":0.902921289537234,"d":"0.90"},{"v":0.873079566523083,"d":"0.87"},{"v":0.8655864572643,"d":"0.87"},{"v":0.883353322866324,"d":"0.88"},{"v":0.940892974318417,"d":"0.94"},{"v":0.975289449101936,"d":"0.98"},{"v":0.981276265358991,"d":"0.98"},{"v":0.961292663071595,"d":"0.96"},{"v":0.956216102521797,"d":"0.96"},{"v":0.923205247718793,"d":"0.92"},{"v":0.888327730097302,"d":"0.89"},{"v":0.927785485676102,"d":"0.93"},{"v":0.906417271474786,"d":"0.91"},{"v":0.958663059804827,"d":"0.96"},{"v":0.866687448531758,"d":"0.87"},{"v":0.942666343933766,"d":"0.94"},{"v":0.928313389393508,"d":"0.93"},{"v":0.952222608256235,"d":"0.95"}]
["L-Allothreonine",{"$nulls":11},{"v":1,"d":"1.00"},{"v":0.980413795090754,"d":"0.98"},{"v":0.975202178349835,"d":"0.98"},{"v":0.885928100091285,"d":"0.89"},{"v":0.887577090302079,"d":"0.89"},{"v":0.863276570382963,"d":"0.86"},{"v":0.87212412843075,"d":"0.87"},{"v":0.906256338598188,"d":"0.91"},{"v":0.957496927151766,"d":"0.96"},{"v":0.980816393951581,"d":"0.98"},{"v":0.976396823661636,"d":"0.98"},{"v":0.960738907819666,"d":"0.96"},{"v":0.960631580837315,"d":"0.96"},{"v":0.89960264739424,"d":"0.90"},{"v":0.862782213560556,"d":"0.86"},{"v":0.915984868737724,"d":"0.92"},{"v":0.885279883372383,"d":"0.89"},{"v":0.945466602918332,"d":"0.95"},{"v":0.891508445986852,"d":"0.89"},{"v":0.936278354031149,"d":"0.94"},{"v":0.929020448888328,"d":"0.93"},{"v":0.941946395444908,"d":"0.94"}]
["Mannitol",{"$nulls":12},{"v":1,"d":"1.00"},{"v":0.970895544856521,"d":"0.97"},{"v":0.928202474380217,"d":"0.93"},{"v":0.939413050529426,"d":"0.94"},{"v":0.908269672537071,"d":"0.91"},{"v":0.860704783148727,"d":"0.86"},{"v":0.860709613124955,"d":"0.86"},{"v":0.903718236566593,"d":"0.90"},{"v":0.967883917025279,"d":"0.97"},{"v":0.976689028283441,"d":"0.98"},{"v":0.939623120571625,"d":"0.94"},{"v":0.92863027296887,"d":"0.93"},{"v":0.922626252661104,"d":"0.92"},{"v":0.877332370817111,"d":"0.88"},{"v":0.911082817099445,"d":"0.91"},{"v":0.921165833083736,"d":"0.92"},{"v":0.964900266241916,"d":"0.96"},{"v":0.868691708321161,"d":"0.87"},{"v":0.91543684905897,"d":"0.92"},{"v":0.931313179378146,"d":"0.93"},{"v":0.934061006015598,"d":"0.93"}]
["N-Acetylgalactosamine",{"$nulls":13},{"v":1,"d":"1.00"},{"v":0.863297350047441,"d":"0.86"},{"v":0.889895927041663,"d":"0.89"},{"v":0.912060769862234,"d":"0.91"},{"v":0.823948564059933,"d":"0.82"},{"v":0.948022365206736,"d":"0.95"},{"v":0.923641074248756,"d":"0.92"},{"v":0.932883755429686,"d":"0.93"},{"v":0.925359659097565,"d":"0.93"},{"v":0.908547692702924,"d":"0.91"},{"v":0.893789036066774,"d":"0.89"},{"v":0.822453797499042,"d":"0.82"},{"v":0.773821974200485,"d":"0.77"},{"v":0.842246644340728,"d":"0.84"},{"v":0.827829350058165,"d":"0.83"},{"v":0.894407422158684,"d":"0.89"},{"v":0.880058896434542,"d":"0.88"},{"v":0.85648821700498,"d":"0.86"},{"v":0.869906199536908,"d":"0.87"},{"v":0.88693767523692,"d":"0.89"}]
["Hypoxanthine",{"$nulls":14},{"v":1,"d":"1.00"},{"v":0.935680896478738,"d":"0.94"},{"v":0.912419559713182,"d":"0.91"},{"v":0.694902778771371,"d":"0.69"},{"v":0.683445166055872,"d":"0.68"},{"v":0.752287798891024,"d":"0.75"},{"v":0.87971428436294,"d":"0.88"},{"v":0.907419099244047,"d":"0.91"},{"v":0.873817458924057,"d":"0.87"},{"v":0.835393629406553,"d":"0.84"},{"v":0.948815743224831,"d":"0.95"},{"v":0.879401137466523,"d":"0.88"},{"v":0.821535472877368,"d":"0.82"},{"v":0.889815211782193,"d":"0.89"},{"v":0.890645340691495,"d":"0.89"},{"v":0.748853324801674,"d":"0.75"},{"v":0.925240665578748,"d":"0.93"},{"v":0.887164279832786,"d":"0.89"},{"v":0.912315807372028,"d":"0.91"}]
["L-Histidine",{"$nulls":15},{"v":1,"d":"1.00"},{"v":0.946704431186725,"d":"0.95"},{"v":0.817721067773388,"d":"0.82"},{"v":0.737661161086566,"d":"0.74"},{"v":0.760386931181999,"d":"0.76"},{"v":0.853199791432139,"d":"0.85"},{"v":0.883354882754715,"d":"0.88"},{"v":0.896867887165946,"d":"0.90"},{"v":0.843569020248379,"d":"0.84"},{"v":0.896747648611446,"d":"0.90"},{"v":0.858990518204717,"d":"0.86"},{"v":0.837339449234888,"d":"0.84"},{"v":0.90956471189,"d":"0.91"},{"v":0.925717753774152,"d":"0.93"},{"v":0.735358451955909,"d":"0.74"},{"v":0.856320952925939,"d":"0.86"},{"v":0.842447294397068,"d":"0.84"},{"v":0.845336803545426,"d":"0.85"}]
["Creatine",{"$nulls":16},{"v":1,"d":"1.00"},{"v":0.695007929311492,"d":"0.70"},{"v":0.790548941072218,"d":"0.79"},{"v":0.713203122631235,"d":"0.71"},{"v":0.78982381690606,"d":"0.79"},{"v":0.813386917747864,"d":"0.81"},{"v":0.827439575961011,"d":"0.83"},{"v":0.751386756347152,"d":"0.75"},{"v":0.793831964336406,"d":"0.79"},{"v":0.715094354498935,"d":"0.72"},{"v":0.705882481764318,"d":"0.71"},{"v":0.772812104681696,"d":"0.77"},{"v":0.818498614193863,"d":"0.82"},{"v":0.727563893141036,"d":"0.73"},{"v":0.79698159194567,"d":"0.80"},{"v":0.758980965446072,"d":"0.76"},{"v":0.782273157699166,"d":"0.78"}]
["N-Acetyl-L-alanine",{"$nulls":17},{"v":1,"d":"1.00"},{"v":0.787266674488905,"d":"0.79"},{"v":0.869017838370919,"d":"0.87"},{"v":0.861755007682545,"d":"0.86"},{"v":0.871460788084548,"d":"0.87"},{"v":0.902987159835786,"d":"0.90"},{"v":0.916247446286363,"d":"0.92"},{"v":0.798247626274549,"d":"0.80"},{"v":0.843854632548843,"d":"0.84"},{"v":0.923103887451579,"d":"0.92"},{"v":0.87413938458938,"d":"0.87"},{"v":0.926814399046051,"d":"0.93"},{"v":0.744820249889843,"d":"0.74"},{"v":0.802047422633839,"d":"0.80"},{"v":0.809472304412609,"d":"0.81"},{"v":0.787218164935105,"d":"0.79"}]
["3-Methylxanthine",{"$nulls":18},{"v":1,"d":"1.00"},{"v":0.922942609789185,"d":"0.92"},{"v":0.842926084643366,"d":"0.84"},{"v":0.813960178222465,"d":"0.81"},{"v":0.841161069977589,"d":"0.84"},{"v":0.833920413258713,"d":"0.83"},{"v":0.651919968526311,"d":"0.65"},{"v":0.636344545701458,"d":"0.64"},{"v":0.746567095966158,"d":"0.75"},{"v":0.667614968502369,"d":"0.67"},{"v":0.773262158711166,"d":"0.77"},{"v":0.806614581153816,"d":"0.81"},{"v":0.735139712499963,"d":"0.74"},{"v":0.725598717085906,"d":"0.73"},{"v":0.764914451960675,"d":"0.76"}]
["Propionylglycine",{"$nulls":19},{"v":1,"d":"1.00"},{"v":0.955160040707225,"d":"0.96"},{"v":0.930755659211892,"d":"0.93"},{"v":0.925077641723763,"d":"0.93"},{"v":0.958065797248591,"d":"0.96"},{"v":0.814005045868995,"d":"0.81"},{"v":0.81817923924926,"d":"0.82"},{"v":0.902294520372221,"d":"0.90"},{"v":0.822918320908751,"d":"0.82"},{"v":0.889194296129643,"d":"0.89"},{"v":0.85745257259206,"d":"0.86"},{"v":0.870775714991623,"d":"0.87"},{"v":0.877998976407017,"d":"0.88"},{"v":0.905191710449835,"d":"0.91"}]
["N-Acetylneuraminic acid",{"$nulls":20},{"v":1,"d":"1.00"},{"v":0.99319785684767,"d":"0.99"},{"v":0.943644208018709,"d":"0.94"},{"v":0.968104801326931,"d":"0.97"},{"v":0.928807452272534,"d":"0.93"},{"v":0.901186007856764,"d":"0.90"},{"v":0.94275945590078,"d":"0.94"},{"v":0.91599793396683,"d":"0.92"},{"v":0.956631654304219,"d":"0.96"},{"v":0.882253490686647,"d":"0.88"},{"v":0.939488151193096,"d":"0.94"},{"v":0.961798169727687,"d":"0.96"},{"v":0.964647079172374,"d":"0.96"}]
["Betaine",{"$nulls":21},{"v":1,"d":"1.00"},{"v":0.9482191060996,"d":"0.95"},{"v":0.963929028946132,"d":"0.96"},{"v":0.955299736465651,"d":"0.96"},{"v":0.922860823810162,"d":"0.92"},{"v":0.955868806264419,"d":"0.96"},{"v":0.943623822574241,"d":"0.94"},{"v":0.975857583344717,"d":"0.98"},{"v":0.87537992481777,"d":"0.88"},{"v":0.95450687854301,"d":"0.95"},{"v":0.96861114108755,"d":"0.97"},{"v":0.970571188544738,"d":"0.97"}]
["D-Glucuronic acid",{"$nulls":22},{"v":1,"d":"1.00"},{"v":0.980760733196325,"d":"0.98"},{"v":0.919070745819569,"d":"0.92"},{"v":0.924105804326903,"d":"0.92"},{"v":0.926074178226184,"d":"0.93"},{"v":0.892284593511581,"d":"0.89"},{"v":0.955613656384044,"d":"0.96"},{"v":0.761676727465658,"d":"0.76"},{"v":0.94781366672277,"d":"0.95"},{"v":0.872827806772194,"d":"0.87"},{"v":0.906509875993561,"d":"0.91"}]
["7-Methylxanthine",{"$nulls":23},{"v":1,"d":"1.00"},{"v":0.915330421315981,"d":"0.92"},{"v":0.927444450411839,"d":"0.93"},{"v":0.963530836424091,"d":"0.96"},{"v":0.911562632615674,"d":"0.91"},{"v":0.958119999278417,"d":"0.96"},{"v":0.812594894014759,"d":"0.81"},{"v":0.943647261260296,"d":"0.94"},{"v":0.914391431038484,"d":"0.91"},{"v":0.929420273880596,"d":"0.93"}]
["Palmitoylcarnitine",{"$nulls":24},{"v":1,"d":"1.00"},{"v":0.973083911054813,"d":"0.97"},{"v":0.925129330207196,"d":"0.93"},{"v":0.954089915536368,"d":"0.95"},{"v":0.954090791655976,"d":"0.95"},{"v":0.750183083894701,"d":"0.75"},{"v":0.962972542319274,"d":"0.96"},{"v":0.934892146301646,"d":"0.93"},{"v":0.951876273023701,"d":"0.95"}]
["2-Hydroxybutyric acid",{"$nulls":25},{"v":1,"d":"1.00"},{"v":0.937343331392547,"d":"0.94"},{"v":0.943110039295462,"d":"0.94"},{"v":0.947603656081861,"d":"0.95"},{"v":0.661014861400869,"d":"0.66"},{"v":0.926096610929209,"d":"0.93"},{"v":0.881884658467543,"d":"0.88"},{"v":0.914307399021895,"d":"0.91"}]
["Tryptamine",{"$nulls":26},{"v":1,"d":"1.00"},{"v":0.961441355743092,"d":"0.96"},{"v":0.971086787528928,"d":"0.97"},{"v":0.826501814602875,"d":"0.83"},{"v":0.909509905180299,"d":"0.91"},{"v":0.933312270488416,"d":"0.93"},{"v":0.917075291835605,"d":"0.92"}]
["Caffeine",{"$nulls":27},{"v":1,"d":"1.00"},{"v":0.973918400101697,"d":"0.97"},{"v":0.802026715988706,"d":"0.80"},{"v":0.897575257529599,"d":"0.90"},{"v":0.94788823985736,"d":"0.95"},{"v":0.923690975934775,"d":"0.92"}]
["FAD",{"$nulls":28},{"v":1,"d":"1.00"},{"v":0.812411477795642,"d":"0.81"},{"v":0.923434898573397,"d":"0.92"},{"v":0.933969767676796,"d":"0.93"},{"v":0.926748453950606,"d":"0.93"}]
["Dimethylglycine",{"$nulls":29},{"v":1,"d":"1.00"},{"v":0.798965236765916,"d":"0.80"},{"v":0.912604255727723,"d":"0.91"},{"v":0.853329721773826,"d":"0.85"}]
["Putrescine",{"$nulls":30},{"v":1,"d":"1.00"},{"v":0.927161716582158,"d":"0.93"},{"v":0.955582424948397,"d":"0.96"}]
["L-Threonine",{"$nulls":31},{"v":1,"d":"1.00"},{"v":0.970527211250761,"d":"0.97"}]
["Guanidoacetic acid",{"$nulls":32},{"v":1,"d":"1.00"}]

{"sheet":"Table S2","index":1,"n_rows":35,"n_cols":34,"rows_kept":35,"merged":[[0,0,0,11]],"flags":["formulas_cached_only"]}
["Table S2. Matrix of P values from spearman rank correlation corresponing to Figure 4a."]
[null,"IL-1β","TNFa","Body Weight","Methylguanidine","IFN-γ","Bacterial Load","Carnosine","Deoxyuridine","Glycerophosphocholine","p-Hydroxyphenylacetic-acid","Taurine","L-Allothreonine","Mannitol","N-Acetylgalactosamine","Hypoxanthine","L-Histidine","Creatine","N-Acetyl-L-alanine","3-Methylxanthine","Propionylglycine","N-Acetylneuraminic acid","Betaine","D-Glucuronic acid","7-Methylxanthine","Palmitoylcarnitine","2-Hydroxybutyric acid","Tryptamine","Caffeine","FAD","Dimethylglycine","Putrescine","L-Threonine","Guanidoacetic acid"]
["IL-1β",{"v":0,"d":"0.00E+00"},{"v":1.12281320861234e-07,"d":"1.12E-07"},{"v":0.283457736413714,"d":"2.83E-01"},{"v":0.138629795743812,"d":"1.39E-01"},{"v":0.582689606023003,"d":"5.83E-01"},{"v":0.228955684315162,"d":"2.29E-01"},{"v":0.0284567490447807,"d":"2.85E-02"},{"v":0.00682865694988273,"d":"6.83E-03"},{"v":0.896599609320533,"d":"8.97E-01"},{"v":0.882783969690923,"d":"8.83E-01"},{"v":0.464176556041432,"d":"4.64E-01"},{"v":0.83448868854912,"d":"8.34E-01"},{"v":0.386003912775416,"d":"3.86E-01"},{"v":0.905837892314433,"d":"9.06E-01"},{"v":0.040759059359074,"d":"4.08E-02"},{"v":0.247228797590367,"d":"2.47E-01"},{"v":0.294479178500935,"d":"2.94E-01"},{"v":0.880128152720619,"d":"8.80E-01"},{"v":0.430654244956756,"d":"4.31E-01"},{"v":0.732868845549284,"d":"7.33E-01"},{"v":0.569496481296844,"d":"5.69E-01"},{"v":0.365357132434312,"d":"3.65E-01"},{"v":0.573724764094205,"d":"5.74E-01"},{"v":0.749788298567325,"d":"7.50E-01"},{"v":0.0512306131096904,"d":"5.12E-02"},{"v":0.044386825556231,"d":"4.44E-02"},{"v":0.519478969786893,"d":"5.19E-01"},{"v":0.201886383494598,"d":"2.02E-01"},{"v":0.308073141562555,"d":"3.08E-01"},{"v":0.345456682185273,"d":"3.45E-01"},{"v":0.276273707918123,"d":"2.76E-01"},{"v":0.515405240567261,"d":"5.15E-01"},{"v":0.209542122591435,"d":"2.10E-01"}]
["TNFa",null,{"v":0,"d":"0.00E+00"},{"v":0.812902236155353,"d":"8.13E-01"},{"v":0.617338418916659,"d":"6.17E-01"},{"v":0.000773461707043403,"d":"7.73E-04"},{"v":0.152706044471682,"d":"1.53E-01"},{"v":0.00143922973826919,"d":"1.44E-03"},{"v":0.000405342430672888,"d":"4.05E-04"},{"v":0.293992095617507,"d":"2.94E-01"},{"v":0.220422846059882,"d":"2.20E-01"},{"v":0.790085749107833,"d":"7.90E-01"},{"v":0.446542687288844,"d":"4.47E-01"},{"v":0.812671411929039,"d":"8.13E-01"},{"v":0.29000466392538,"d":"2.90E-01"},{"v":0.544305646997397,"d":"5.44E-01"},{"v":0.541974040527285,"d":"5.42E-01"},{"v":0.892233041390291,"d":"8.92E-01"},{"v":0.98827484522993,"d":"9.88E-01"},{"v":0.0909684435117001,"d":"9.10E-02"},{"v":0.318898950019438,"d":"3.19E-01"},{"v":0.659507892648563,"d":"6.60E-01"},{"v":0.888526275718437,"d":"8.89E-01"},{"v":0.747542384631041,"d":"7.48E-01"},{"v":0.980947779208384,"d":"9.81E-01"},{"v":0.288111359602304,"d":"2.88E-01"},{"v":0.0888999892866768,"d":"8.89E-02"},{"v":0.843564524046749,"d":"8.44E-01"},{"v":0.507651172931938,"d":"5.08E-01"},{"v":0.611804568517959,"d":"6.12E-01"},{"v":0.00667464422740527,"d":"6.67E-03"},{"v":0.905197601393682,"d":"9.05E-01"},{"v":0.549410425076332,"d":"5.49E-01"},{"v":0.987788463608645,"d":"9.88E-01"}]
["Body Weight",null,null,{"v":0,"d":"0.00E+00"},{"v":4.85409320415352e-19,"d":"4.85E-19"},{"v":0.114274312744988,"d":"1.14E-01"},{"v":0.00310430558302313,"d":"3.10E-03"},{"v":1.04810579768988e-06,"d":"1.05E-06"},{"v":6.99668544600874e-07,"d":"7.00E-07"},{"v":0.0027191927991666,"d":"2.72E-03"},{"v":9.2797616367485e-08,"d":"9.28E-08"},{"v":3.07023729730318e-14,"d":"3.07E-14"},{"v":2.03364499923266e-14,"d":"2.03E-14"},{"v":3.78987185508122e-15,"d":"3.79E-15"},{"v":5.14493224251546e-11,"d":"5.14E-11"},{"v":5.93797192230042e-18,"d":"5.94E-18"},{"v":1.35531698029551e-13,"d":"1.36E-13"},{"v":4.30840092267405e-10,"d":"4.31E-10"},{"v":4.4802960879908e-07,"d":"4.48E-07"},{"v":3.84108493396576e-06,"d":"3.84E-06"},{"v":2.84964968925859e-09,"d":"2.85E-09"},{"v":4.82989906831476e-15,"d":"4.83E-15"},{"v":7.20460298604247e-16,"d":"7.20E-16"},{"v":7.62858765577269e-14,"d":"7.63E-14"},{"v":9.11157215437067e-13,"d":"9.11E-13"},{"v":6.47576341596056e-19,"d":"6.48E-19"},{"v":2.27807922134681e-13,"d":"2.28E-13"},{"v":5.65808657467182e-11,"d":"5.66E-11"},{"v":4.59101899680216e-13,"d":"4.59E-13"},{"v":5.32577254973799e-14,"d":"5.33E-14"},{"v":4.35171126050093e-08,"d":"4.35E-08"},{"v":5.32035048650307e-17,"d":"5.32E-17"},{"v":6.46271232832227e-15,"d":"6.46E-15"},{"v":3.79733825421317e-16,"d":"3.80E-16"}]
["Methylguanidine",{"$nulls":3},{"v":0,"d":"0.00E+00"},{"v":0.0740256288360019,"d":"7.40E-02"},{"v":0.000554060784210267,"d":"5.54E-04"},{"v":3.10053927331752e-07,"d":"3.10E-07"},{"v":3.35871158150338e-07,"d":"3.36E-07"},{"v":0.00164440789526124,"d":"1.64E-03"},{"v":2.3630740628735e-09,"d":"2.36E-09"},{"v":3.54886359947516e-22,"d":"3.55E-22"},{"v":1.01936468826437e-18,"d":"1.02E-18"},{"v":4.97771404106207e-20,"d":"4.98E-20"},{"v":2.43151387978544e-13,"d":"2.43E-13"},{"v":5.88450024178782e-17,"d":"5.88E-17"},{"v":2.0368076437027e-13,"d":"2.04E-13"},{"v":5.69240898914817e-10,"d":"5.69E-10"},{"v":2.3269601369959e-09,"d":"2.33E-09"},{"v":7.88395232802994e-08,"d":"7.88E-08"},{"v":1.93732370719396e-12,"d":"1.94E-12"},{"v":1.74902812111887e-20,"d":"1.75E-20"},{"v":1.99517948295137e-24,"d":"2.00E-24"},{"v":5.47060750135634e-18,"d":"5.47E-18"},{"v":6.29644714317227e-17,"d":"6.30E-17"},{"v":7.83610563409246e-23,"d":"7.84E-23"},{"v":5.04341627191521e-17,"d":"5.04E-17"},{"v":9.81584661743938e-15,"d":"9.82E-15"},{"v":1.28447186504962e-15,"d":"1.28E-15"},{"v":1.71338975377407e-19,"d":"1.71E-19"},{"v":1.4847531003522e-08,"d":"1.48E-08"},{"v":1.2098326063755e-20,"d":"1.21E-20"},{"v":1.9862723945038e-16,"d":"1.99E-16"},{"v":2.9307468944345e-22,"d":"2.93E-22"}]
["IFN-γ",{"$nulls":4},{"v":0,"d":"0.00E+00"},{"v":0.00131575241903565,"d":"1.32E-03"},{"v":1.33447162020622e-06,"d":"1.33E-06"},{"v":2.142381155782e-05,"d":"2.14E-05"},{"v":0.806203976896769,"d":"8.06E-01"},{"v":0.661238349448774,"d":"6.61E-01"},{"v":0.133429567038946,"d":"1.33E-01"},{"v":0.177833328563673,"d":"1.78E-01"},{"v":0.200201669438496,"d":"2.00E-01"},{"v":0.484993844006623,"d":"4.85E-01"},{"v":0.267950622695454,"d":"2.68E-01"},{"v":0.0412303744691903,"d":"4.12E-02"},{"v":0.39603741215334,"d":"3.96E-01"},{"v":0.00133374541591504,"d":"1.33E-03"},{"v":0.545336728478076,"d":"5.45E-01"},{"v":0.162309831344209,"d":"1.62E-01"},{"v":0.19067703165062,"d":"1.91E-01"},{"v":0.1210000648184,"d":"1.21E-01"},{"v":0.00570638668131462,"d":"5.71E-03"},{"v":0.0153183937962028,"d":"1.53E-02"},{"v":0.0298156755122834,"d":"2.98E-02"},{"v":0.00237157674946735,"d":"2.37E-03"},{"v":0.0143460178542022,"d":"1.43E-02"},{"v":0.0294708984209981,"d":"2.95E-02"},{"v":0.0133706818916139,"d":"1.34E-02"},{"v":0.798122822424823,"d":"7.98E-01"},{"v":0.0526862518216814,"d":"5.27E-02"},{"v":0.364194668842577,"d":"3.64E-01"},{"v":0.26247838486934,"d":"2.62E-01"}]
["Bacterial Load",{"$nulls":5},{"v":0,"d":"0.00E+00"},{"v":5.13898158946485e-07,"d":"5.14E-07"},{"v":1.46922201595247e-05,"d":"1.47E-05"},{"v":0.516833649612945,"d":"5.17E-01"},{"v":0.00696095089530013,"d":"6.96E-03"},{"v":0.000357414301383192,"d":"3.57E-04"},{"v":0.000505024913125455,"d":"5.05E-04"},{"v":0.00219241745413075,"d":"2.19E-03"},{"v":0.00275769874407032,"d":"2.76E-03"},{"v":0.00418243171665527,"d":"4.18E-03"},{"v":0.00743116794841747,"d":"7.43E-03"},{"v":0.0101579170545282,"d":"1.02E-02"},{"v":0.000425171365508268,"d":"4.25E-04"},{"v":0.000758643489699364,"d":"7.59E-04"},{"v":0.000434292904442563,"d":"4.34E-04"},{"v":0.0012402974019266,"d":"1.24E-03"},{"v":0.00128311617219196,"d":"1.28E-03"},{"v":1.11198008377355e-05,"d":"1.11E-05"},{"v":3.47532790335683e-05,"d":"3.48E-05"},{"v":0.000792823340547264,"d":"7.93E-04"},{"v":6.93331340968368e-05,"d":"6.93E-05"},{"v":0.000417263365413463,"d":"4.17E-04"},{"v":0.0111419789971046,"d":"1.11E-02"},{"v":0.000949636174154016,"d":"9.50E-04"},{"v":0.119475873292294,"d":"1.19E-01"},{"v":0.000121364929920635,"d":"1.21E-04"},{"v":0.0276925684493138,"d":"2.77E-02"},{"v":0.00423359761300715,"d":"4.23E-03"}]
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["L-Allothreonine",{"$nulls":11},{"v":0,"d":"0.00E+00"},{"v":1.93092376314569e-23,"d":"1.93E-23"},{"v":7.21732542826404e-22,"d":"7.22E-22"},{"v":7.2231740464769e-12,"d":"7.22E-12"},{"v":5.83235562490057e-12,"d":"5.83E-12"},{"v":1.01642842451537e-10,"d":"1.02E-10"},{"v":3.84180759818768e-11,"d":"3.84E-11"},{"v":3.98653403613906e-13,"d":"3.99E-13"},{"v":2.70592210618359e-18,"d":"2.71E-18"},{"v":1.40331640097378e-23,"d":"1.40E-23"},{"v":3.38517095146315e-22,"d":"3.39E-22"},{"v":8.09066257262787e-19,"d":"8.09E-19"},{"v":8.43408094207222e-19,"d":"8.43E-19"},{"v":1.10058428252446e-12,"d":"1.10E-12"},{"v":1.07106476262135e-10,"d":"1.07E-10"},{"v":7.81620910418113e-14,"d":"7.82E-14"},{"v":7.84968461806527e-12,"d":"7.85E-12"},{"v":1.18495086544601e-16,"d":"1.18E-16"},{"v":3.45508876751171e-12,"d":"3.46E-12"},{"v":1.24155863818969e-15,"d":"1.24E-15"},{"v":6.27991121606019e-15,"d":"6.28E-15"},{"v":3.0486211170634e-16,"d":"3.05E-16"}]
["Mannitol",{"$nulls":12},{"v":0,"d":"0.00E+00"},{"v":8.38388404379433e-21,"d":"8.38E-21"},{"v":7.45737994426891e-15,"d":"7.46E-15"},{"v":5.80671417400077e-16,"d":"5.81E-16"},{"v":2.88840139159241e-13,"d":"2.89E-13"},{"v":1.33174033507299e-10,"d":"1.33E-10"},{"v":1.33107143466549e-10,"d":"1.33E-10"},{"v":5.92366098945916e-13,"d":"5.92E-13"},{"v":3.77782849766007e-20,"d":"3.78E-20"},{"v":2.79639093647604e-22,"d":"2.80E-22"},{"v":5.5104671890102e-16,"d":"5.51E-16"},{"v":6.81810834945491e-15,"d":"6.82E-15"},{"v":2.28576306904883e-14,"d":"2.29E-14"},{"v":2.09381618747744e-11,"d":"2.09E-11"},{"v":1.81825167619282e-13,"d":"1.82E-13"},{"v":3.02293845688336e-14,"d":"3.02E-14"},{"v":1.46653476428809e-19,"d":"1.47E-19"},{"v":5.65026441837045e-11,"d":"5.65E-11"},{"v":8.61149668565027e-14,"d":"8.61E-14"},{"v":3.83640995070325e-15,"d":"3.84E-15"},{"v":2.07716753341469e-15,"d":"2.08E-15"}]
["N-Acetylgalactosamine",{"$nulls":13},{"v":0,"d":"0.00E+00"},{"v":1.01418940351996e-10,"d":"1.01E-10"},{"v":4.2930100262168e-12,"d":"4.29E-12"},{"v":1.54247421225439e-13,"d":"1.54E-13"},{"v":3.83651472403331e-09,"d":"3.84E-09"},{"v":5.73231197137124e-17,"d":"5.73E-17"},{"v":1.87613850489887e-14,"d":"1.88E-14"},{"v":2.71022805510496e-15,"d":"2.71E-15"},{"v":1.33440839490622e-14,"d":"1.33E-14"},{"v":2.76109585782463e-13,"d":"2.76E-13"},{"v":2.52656524104441e-12,"d":"2.53E-12"},{"v":4.32567102222089e-09,"d":"4.33E-09"},{"v":1.28165056754884e-07,"d":"1.28E-07"},{"v":8.010017647125e-10,"d":"8.01E-10"},{"v":2.79464691537531e-09,"d":"2.79E-09"},{"v":2.31815529456212e-12,"d":"2.32E-12"},{"v":1.50713472793214e-11,"d":"1.51E-11"},{"v":2.050498769596e-10,"d":"2.05E-10"},{"v":4.93549928279281e-11,"d":"4.94E-11"},{"v":6.33914882371825e-12,"d":"6.34E-12"}]
["Hypoxanthine",{"$nulls":14},{"v":0,"d":"0.00E+00"},{"v":1.42879426126414e-15,"d":"1.43E-15"},{"v":1.45144784964173e-13,"d":"1.45E-13"},{"v":7.21466179298201e-06,"d":"7.21E-06"},{"v":1.16718424664736e-05,"d":"1.17E-05"},{"v":4.4549851196566e-07,"d":"4.45E-07"},{"v":1.57176864950016e-11,"d":"1.57E-11"},{"v":3.31257222050449e-13,"d":"3.31E-13"},{"v":3.16306852348512e-11,"d":"3.16E-11"},{"v":1.47251490016569e-09,"d":"1.47E-09"},{"v":4.54140167350844e-17,"d":"4.54E-17"},{"v":1.63272102783614e-11,"d":"1.63E-11"},{"v":4.65407124468133e-09,"d":"4.65E-09"},{"v":4.33954165276617e-12,"d":"4.34E-12"},{"v":3.88255522340976e-12,"d":"3.88E-12"},{"v":5.37184961634712e-07,"d":"5.37E-07"},{"v":1.36662006403392e-14,"d":"1.37E-14"},{"v":6.15504665194935e-12,"d":"6.16E-12"},{"v":1.47724305611063e-13,"d":"1.48E-13"}]
["L-Histidine",{"$nulls":15},{"v":0,"d":"0.00E+00"},{"v":8.37325227616911e-17,"d":"8.37E-17"},{"v":6.27961566986681e-09,"d":"6.28E-09"},{"v":9.68932709852761e-07,"d":"9.69E-07"},{"v":2.83082355510772e-07,"d":"2.83E-07"},{"v":2.84426645037818e-10,"d":"2.84E-10"},{"v":1.00200158412599e-11,"d":"1.00E-11"},{"v":1.63705024348452e-12,"d":"1.64E-12"},{"v":7.09858610621108e-10,"d":"7.10E-10"},{"v":1.66545472569986e-12,"d":"1.67E-12"},{"v":1.58983054321904e-10,"d":"1.59E-10"},{"v":1.24227150384234e-09,"d":"1.24E-09"},{"v":2.33849737139961e-13,"d":"2.34E-13"},{"v":1.24168415692323e-14,"d":"1.24E-14"},{"v":1.08997897140564e-06,"d":"1.09E-06"},{"v":2.08531785354851e-10,"d":"2.09E-10"},{"v":7.86509625461582e-10,"d":"7.87E-10"},{"v":6.02952360768897e-10,"d":"6.03E-10"}]
["Creatine",{"$nulls":16},{"v":0,"d":"0.00E+00"},{"v":7.18215342745671e-06,"d":"7.18E-06"},{"v":4.41883290598519e-08,"d":"4.42E-08"},{"v":3.1918674494044e-06,"d":"3.19E-06"},{"v":4.63669250678129e-08,"d":"4.64E-08"},{"v":8.75309250708579e-09,"d":"8.75E-09"},{"v":2.88603160979348e-09,"d":"2.89E-09"},{"v":4.68053226312237e-07,"d":"4.68E-07"},{"v":3.54528134417935e-08,"d":"3.55E-08"},{"v":2.92351678773658e-06,"d":"2.92E-06"},{"v":4.45547204779801e-06,"d":"4.46E-06"},{"v":1.36282380443252e-07,"d":"1.36E-07"},{"v":5.91095901784462e-09,"d":"5.91E-09"},{"v":1.60944501865573e-06,"d":"1.61E-06"},{"v":2.85930771315723e-08,"d":"2.86E-08"},{"v":3.0665101429909e-07,"d":"3.07E-07"},{"v":7.5706970722733e-08,"d":"7.57E-08"}]
["N-Acetyl-L-alanine",{"$nulls":17},{"v":0,"d":"0.00E+00"},{"v":5.48620493604233e-08,"d":"5.49E-08"},{"v":5.44945444468242e-11,"d":"5.45E-11"},{"v":1.19339521079103e-10,"d":"1.19E-10"},{"v":4.14270623884966e-11,"d":"4.14E-11"},{"v":6.62599510641419e-13,"d":"6.63E-13"},{"v":7.45987252839657e-14,"d":"7.46E-14"},{"v":2.61977225014791e-08,"d":"2.62E-08"},{"v":6.9147699877551e-10,"d":"6.91E-10"},{"v":2.08358317542871e-14,"d":"2.08E-14"},{"v":3.04734214216257e-11,"d":"3.05E-11"},{"v":9.93674980689023e-15,"d":"9.94E-15"},{"v":6.66712039386725e-07,"d":"6.67E-07"},{"v":2.00724516056362e-08,"d":"2.01E-08"},{"v":1.17294536770474e-08,"d":"1.17E-08"},{"v":5.5036205945016e-08,"d":"5.50E-08"}]
["3-Methylxanthine",{"$nulls":18},{"v":0,"d":"0.00E+00"},{"v":2.14991122746914e-14,"d":"2.15E-14"},{"v":7.52902023812702e-10,"d":"7.53E-10"},{"v":8.38105621698384e-09,"d":"8.38E-09"},{"v":8.83781238082621e-10,"d":"8.84E-10"},{"v":1.67238782881883e-09,"d":"1.67E-09"},{"v":3.95428715209828e-05,"d":"3.95E-05"},{"v":6.87348168967044e-05,"d":"6.87E-05"},{"v":6.07459414146273e-07,"d":"6.07E-07"},{"v":2.19298189628303e-05,"d":"2.19E-05"},{"v":1.32608310387194e-07,"d":"1.33E-07"},{"v":1.44629923041903e-08,"d":"1.45E-08"},{"v":1.10216712071021e-06,"d":"1.10E-06"},{"v":1.77195008400805e-06,"d":"1.77E-06"},{"v":2.18001284603903e-07,"d":"2.18E-07"}]
["Propionylglycine",{"$nulls":19},{"v":0,"d":"0.00E+00"},{"v":6.10325798809545e-18,"d":"6.10E-18"},{"v":4.33153932647825e-15,"d":"4.33E-15"},{"v":1.41192682289131e-14,"d":"1.41E-14"},{"v":2.20457614651409e-18,"d":"2.20E-18"},{"v":8.35256183871347e-09,"d":"8.35E-09"},{"v":6.05989890226884e-09,"d":"6.06E-09"},{"v":7.3620734979712e-13,"d":"7.36E-13"},{"v":4.16782263873708e-09,"d":"4.17E-09"},{"v":4.71346094230943e-12,"d":"4.71E-12"},{"v":1.86002288242322e-10,"d":"1.86E-10"},{"v":4.47627493205105e-11,"d":"4.48E-11"},{"v":1.93349359983436e-11,"d":"1.93E-11"},{"v":4.71332066829374e-13,"d":"4.71E-13"}]
["N-Acetylneuraminic acid",{"$nulls":20},{"v":0,"d":"0.00E+00"},{"v":1.60170208474625e-30,"d":"1.60E-30"},{"v":1.94738440891247e-16,"d":"1.95E-16"},{"v":3.39975407510135e-20,"d":"3.40E-20"},{"v":6.56860075828932e-15,"d":"6.57E-15"},{"v":8.69990104703307e-13,"d":"8.70E-13"},{"v":2.46392454416871e-16,"d":"2.46E-16"},{"v":7.79811083516222e-14,"d":"7.80E-14"},{"v":3.67595540554682e-18,"d":"3.68E-18"},{"v":1.14999194381058e-11,"d":"1.15E-11"},{"v":5.69914146007431e-16,"d":"5.70E-16"},{"v":5.33408595144114e-19,"d":"5.33E-19"},{"v":1.6364941423843e-19,"d":"1.64E-19"}]
["Betaine",{"$nulls":21},{"v":0,"d":"0.00E+00"},{"v":5.41249450902303e-17,"d":"5.41E-17"},{"v":2.22387574964837e-19,"d":"2.22E-19"},{"v":5.82074904094971e-18,"d":"5.82E-18"},{"v":2.18429295291688e-14,"d":"2.18E-14"},{"v":4.79123773251286e-18,"d":"4.79E-18"},{"v":1.9580527724603e-16,"d":"1.96E-16"},{"v":4.78660916492332e-22,"d":"4.79E-22"},{"v":2.63710776424368e-11,"d":"2.64E-11"},{"v":7.60218260024809e-18,"d":"7.60E-18"},{"v":2.662226093776e-20,"d":"2.66E-20"},{"v":9.93295709329176e-21,"d":"9.93E-21"}]
["D-Glucuronic acid",{"$nulls":22},{"v":0,"d":"0.00E+00"},{"v":1.46721152842389e-23,"d":"1.47E-23"},{"v":4.47265633843724e-14,"d":"4.47E-14"},{"v":1.71235310791312e-14,"d":"1.71E-14"},{"v":1.1553774212715e-14,"d":"1.16E-14"},{"v":3.10842259969979e-12,"d":"3.11E-12"},{"v":5.22980073165885e-18,"d":"5.23E-18"},{"v":2.62932561791827e-07,"d":"2.63E-07"},{"v":6.09076801144612e-17,"d":"6.09E-17"},{"v":3.54484203484952e-11,"d":"3.54E-11"},{"v":3.82954536544872e-13,"d":"3.83E-13"}]
["7-Methylxanthine",{"$nulls":23},{"v":0,"d":"0.00E+00"},{"v":8.77441730464819e-14,"d":"8.77E-14"},{"v":8.72906556637203e-15,"d":"8.73E-15"},{"v":2.62915935696563e-19,"d":"2.63E-19"},{"v":1.67767629157904e-13,"d":"1.68E-13"},{"v":2.16163301927007e-18,"d":"2.16E-18"},{"v":9.29217294698847e-09,"d":"9.29E-09"},{"v":1.94579122136971e-16,"d":"1.95E-16"},{"v":1.03412765967457e-13,"d":"1.03E-13"},{"v":5.76964017273898e-15,"d":"5.77E-15"}]
["Palmitoylcarnitine",{"$nulls":24},{"v":0,"d":"0.00E+00"},{"v":2.53403926063788e-21,"d":"2.53E-21"},{"v":1.39741266277301e-14,"d":"1.40E-14"},{"v":8.73164114539931e-18,"d":"8.73E-18"},{"v":8.72911192266242e-18,"d":"8.73E-18"},{"v":4.99813897024498e-07,"d":"5.00E-07"},{"v":3.31442737813445e-19,"d":"3.31E-19"},{"v":1.71638686417996e-15,"d":"1.72E-15"},{"v":1.78402654464103e-17,"d":"1.78E-17"}]
["2-Hydroxybutyric acid",{"$nulls":25},{"v":0,"d":"0.00E+00"},{"v":9.632816173776e-16,"d":"9.63E-16"},{"v":2.24561625058854e-16,"d":"2.25E-16"},{"v":6.47248700151592e-17,"d":"6.47E-17"},{"v":2.82166360428275e-05,"d":"2.82E-05"},{"v":1.15013677122728e-14,"d":"1.15E-14"},{"v":1.2039176021511e-11,"d":"1.20E-11"},{"v":1.04934940295432e-13,"d":"1.05E-13"}]
["Tryptamine",{"$nulls":26},{"v":0,"d":"0.00E+00"},{"v":6.14566414093375e-19,"d":"6.15E-19"},{"v":7.57948825235988e-21,"d":"7.58E-21"},{"v":3.11731173629606e-09,"d":"3.12E-09"},{"v":2.35964297115505e-13,"d":"2.36E-13"},{"v":2.46147591187146e-15,"d":"2.46E-15"},{"v":6.43288226443465e-14,"d":"6.43E-14"}]
["Caffeine",{"$nulls":27},{"v":0,"d":"0.00E+00"},{"v":1.56425066068156e-21,"d":"1.56E-21"},{"v":2.01019140679388e-08,"d":"2.01E-08"},{"v":1.47885075207701e-12,"d":"1.48E-12"},{"v":5.96034964248755e-17,"d":"5.96E-17"},{"v":1.8578774753708e-14,"d":"1.86E-14"}]
["FAD",{"$nulls":28},{"v":0,"d":"0.00E+00"},{"v":9.42129882384386e-09,"d":"9.42E-09"},{"v":1.95337176784915e-14,"d":"1.95E-14"},{"v":2.12080811119373e-15,"d":"2.12E-15"},{"v":1.00717651567202e-14,"d":"1.01E-14"}]
["Dimethylglycine",{"$nulls":29},{"v":0,"d":"0.00E+00"},{"v":2.49234043827615e-08,"d":"2.49E-08"},{"v":1.40656186024022e-13,"d":"1.41E-13"},{"v":2.80815252918012e-10,"d":"2.81E-10"}]
["Putrescine",{"$nulls":30},{"v":0,"d":"0.00E+00"},{"v":9.2530318280762e-15,"d":"9.25E-15"},{"v":5.28598281185986e-18,"d":"5.29E-18"}]
["L-Threonine",{"$nulls":31},{"v":0,"d":"0.00E+00"},{"v":1.01624550418431e-20,"d":"1.02E-20"}]
["Guanidoacetic acid",{"$nulls":32},{"v":0,"d":"0.00E+00"}]

{"sheet":"Table S3","index":2,"n_rows":20,"n_cols":4,"rows_kept":20,"merged":[[0,0,0,3]],"flags":["formulas_cached_only"]}
["Table S3. The predicted pathways correspondingto Figure 4b."]
["Pathway Name","P-Value","fdr-adjusted P-Value","Impact"]
["Glycine, serine and threonine metabolism",{"v":9.3197e-05,"d":"9.32E-05"},{"v":0.0078286,"d":"7.83E-03"},{"v":0.09694,"d":"0.097"}]
["Histidine metabolism",{"v":0.020832,"d":"2.08E-02"},{"v":0.82669,"d":"8.27E-01"},{"v":0.28061,"d":"0.281"}]
["beta-Alanine metabolism",{"v":0.029525,"d":"2.95E-02"},{"v":0.82669,"d":"8.27E-01"},{"v":0.06218,"d":"0.062"}]
["Riboflavin metabolism",{"v":0.059908,"d":"5.99E-02"},{"v":1,"d":"1.00E+00"},{"v":0,"d":"0.000"}]
["Taurine and hypotaurine metabolism",{"v":0.10257,"d":"1.03E-01"},{"v":1,"d":"1.00E+00"},{"v":0.2,"d":"0.200"}]
["Arginine and proline metabolism",{"v":0.11294,"d":"1.13E-01"},{"v":1,"d":"1.00E+00"},{"v":0.03541,"d":"0.035"}]
["Valine, leucine and isoleucine biosynthesis",{"v":0.11638,"d":"1.16E-01"},{"v":1,"d":"1.00E+00"},{"v":0,"d":"0.000"}]
["Ascorbate and aldarate metabolism",{"v":0.12998,"d":"1.30E-01"},{"v":1,"d":"1.00E+00"},0.625]
["Caffeine metabolism",{"v":0.15659,"d":"1.57E-01"},{"v":1,"d":"1.00E+00"},{"v":0,"d":"0.000"}]
["Aminoacyl-tRNA biosynthesis",{"v":0.16553,"d":"1.66E-01"},{"v":1,"d":"1.00E+00"},{"v":0,"d":"0.000"}]
["Pentose and glucuronate interconversions",{"v":0.25547,"d":"2.55E-01"},{"v":1,"d":"1.00E+00"},{"v":0.18182,"d":"0.182"}]
["Propanoate metabolism",{"v":0.30066,"d":"3.01E-01"},{"v":1,"d":"1.00E+00"},{"v":0,"d":"0.000"}]
["Inositol phosphate metabolism",{"v":0.36356,"d":"3.64E-01"},{"v":1,"d":"1.00E+00"},{"v":0,"d":"0.000"}]
["Fatty acid degradation",{"v":0.44789,"d":"4.48E-01"},{"v":1,"d":"1.00E+00"},{"v":0,"d":"0.000"}]
["Amino sugar and nucleotide sugar metabolism",{"v":0.45657,"d":"4.57E-01"},{"v":1,"d":"1.00E+00"},{"v":0,"d":"0.000"}]
["Tryptophan metabolism",{"v":0.45657,"d":"4.57E-01"},{"v":1,"d":"1.00E+00"},{"v":0.02824,"d":"0.028"}]
["Pyrimidine metabolism",{"v":0.47355,"d":"4.74E-01"},{"v":1,"d":"1.00E+00"},{"v":0.06224,"d":"0.062"}]
["Purine metabolism",{"v":0.64732,"d":"6.47E-01"},{"v":1,"d":"1.00E+00"},{"v":0.02445,"d":"0.024"}]

{"sheet":"Table S4","index":3,"n_rows":7,"n_cols":4,"rows_kept":7,"merged":[[0,0,0,3]],"flags":["formulas_cached_only"]}
["Table S4. The predicted pathways correspondingto Figure 4b."]
["Pathway Name","P-Value","fdr-adjusted P-Value","Impact"]
["Glycine, serine and threonine metabolism",{"v":0.00036323,"d":"3.63E-04"},{"v":0.030511,"d":"0.031"},{"v":0.06888,"d":"0.069"}]
["Glycerophospholipid metabolism",{"v":0.013155,"d":"1.32E-02"},{"v":0.55251,"d":"0.553"},{"v":0.06971,"d":"0.070"}]
["Ether lipid metabolism",{"v":0.093638,"d":"9.36E-02"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"}]
["Arginine and proline metabolism",{"v":0.17138,"d":"1.71E-01"},{"v":1,"d":"1.000"},{"v":0.01206,"d":"0.012"}]
["Tyrosine metabolism",{"v":0.18786,"d":"1.88E-01"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"}]