##Databases: Gene Ontology (GO) pathway and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway ##GO_id: the id of GO term gene_id FoldChange log2FoldChange p-value Regulation Expression_C1 Expression_C2 Expression_C3 Expression_Ma1 Expression_Ma2 Expression_Ma3 description GO_id GO_term KEGG pathway KEGG pathway description Abcc4 0.772166024 -0.373017018 0.047142366 Down 1.83547164 1.36403276 1.544775876 1.278214604 1.302758885 1.067672565 "ATP-binding cassette, sub-family C (CFTR/MRP), member 4" "GO:0000166,GO:0001409,GO:0005524,GO:0005886,GO:0005929,GO:0006855,GO:0008559,GO:0015132,GO:0015143,GO:0015216,GO:0015431,GO:0015432,GO:0015562,GO:0015721,GO:0015732,GO:0015747,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016887,GO:0031088,GO:0032310,GO:0034634,GO:0042626,GO:0042910,GO:0048661,GO:0055085,GO:0060271,GO:0070730,GO:0071716,GO:0098591,GO:0140115" nucleotide binding|guanine nucleotide transmembrane transporter activity|ATP binding|plasma membrane|cilium|drug transmembrane transport|ABC-type xenobiotic transporter activity|prostaglandin transmembrane transporter activity|urate transmembrane transporter activity|purine nucleotide transmembrane transporter activity|ABC-type glutathione S-conjugate transporter activity|ABC-type bile acid transporter activity|efflux transmembrane transporter activity|bile acid and bile salt transport|prostaglandin transport|urate transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|ATPase|platelet dense granule membrane|prostaglandin secretion|glutathione transmembrane transporter activity|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|positive regulation of smooth muscle cell proliferation|transmembrane transport|cilium assembly|cAMP transport|leukotriene transport|external side of apical plasma membrane|export across plasma membrane "mmu01523,mmu02010,mmu04024,mmu04976" Antifolate resistance|ABC transporters|cAMP signaling pathway|Bile secretion Acer2 0.71660238 -0.48075526 0.014171568 Down 2.576064845 2.216151694 2.925227996 1.945804958 1.60285329 1.965180719 alkaline ceramidase 2 "GO:0001953,GO:0005794,GO:0006629,GO:0006665,GO:0006672,GO:0006919,GO:0006974,GO:0008284,GO:0010506,GO:0010942,GO:0016020,GO:0016021,GO:0016787,GO:0016811,GO:0017040,GO:0030173,GO:0030330,GO:0032526,GO:0033629,GO:0042981,GO:0046512,GO:0046514,GO:0046872,GO:0071633,GO:0090285,GO:0102121" "negative regulation of cell-matrix adhesion|Golgi apparatus|lipid metabolic process|sphingolipid metabolic process|ceramide metabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|positive regulation of cell population proliferation|regulation of autophagy|positive regulation of cell death|membrane|integral component of membrane|hydrolase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|N-acylsphingosine amidohydrolase activity|integral component of Golgi membrane|DNA damage response, signal transduction by p53 class mediator|response to retinoic acid|negative regulation of cell adhesion mediated by integrin|regulation of apoptotic process|sphingosine biosynthetic process|ceramide catabolic process|metal ion binding|dihydroceramidase activity|negative regulation of protein glycosylation in Golgi|ceramidase activity" "mmu00600,mmu04071" Sphingolipid metabolism|Sphingolipid signaling pathway Adcyap1 1.27652132 0.352217633 0.005331677 Up 3.875155097 4.315932404 3.568384084 4.971693533 5.261728022 4.729432996 adenylate cyclase activating polypeptide 1 "GO:0001541,GO:0001662,GO:0001821,GO:0001932,GO:0002865,GO:0002878,GO:0005102,GO:0005179,GO:0005184,GO:0005576,GO:0005615,GO:0007186,GO:0007189,GO:0007190,GO:0007204,GO:0007218,GO:0007399,GO:0008277,GO:0008284,GO:0010628,GO:0010656,GO:0010976,GO:0016521,GO:0019233,GO:0019933,GO:0030073,GO:0031175,GO:0031858,GO:0032755,GO:0032880,GO:0034260,GO:0043005,GO:0043195,GO:0043204,GO:0043267,GO:0043547,GO:0043950,GO:0045786,GO:0045860,GO:0045944,GO:0046034,GO:0051428,GO:0051968,GO:0060078,GO:0060124,GO:0060253,GO:0070374,GO:0070445,GO:0071651,GO:0090274,GO:0120162" "ovarian follicle development|behavioral fear response|histamine secretion|regulation of protein phosphorylation|negative regulation of acute inflammatory response to antigenic stimulus|negative regulation of acute inflammatory response to non-antigenic stimulus|signaling receptor binding|hormone activity|neuropeptide hormone activity|extracellular region|extracellular space|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|nervous system development|regulation of G protein-coupled receptor signaling pathway|positive regulation of cell population proliferation|positive regulation of gene expression|negative regulation of muscle cell apoptotic process|positive regulation of neuron projection development|pituitary adenylate cyclase activating polypeptide activity|sensory perception of pain|cAMP-mediated signaling|insulin secretion|neuron projection development|pituitary adenylate cyclase-activating polypeptide receptor binding|positive regulation of interleukin-6 production|regulation of protein localization|negative regulation of GTPase activity|neuron projection|terminal bouton|perikaryon|negative regulation of potassium ion transport|positive regulation of GTPase activity|positive regulation of cAMP-mediated signaling|negative regulation of cell cycle|positive regulation of protein kinase activity|positive regulation of transcription by RNA polymerase II|ATP metabolic process|peptide hormone receptor binding|positive regulation of synaptic transmission, glutamatergic|regulation of postsynaptic membrane potential|positive regulation of growth hormone secretion|negative regulation of glial cell proliferation|positive regulation of ERK1 and ERK2 cascade|regulation of oligodendrocyte progenitor proliferation|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of somatostatin secretion|positive regulation of cold-induced thermogenesis" "mmu04024,mmu04080,mmu04713,mmu04911,mmu04924" cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Insulin secretion|Renin secretion Adipor2 0.731641986 -0.450790226 9.24E-06 Down 17.19916359 17.39807322 23.91741223 14.19515922 13.48116199 14.62982234 adiponectin receptor 2 "GO:0001934,GO:0005515,GO:0005886,GO:0006629,GO:0006631,GO:0009755,GO:0010629,GO:0016020,GO:0016021,GO:0019395,GO:0030308,GO:0031226,GO:0033211,GO:0038023,GO:0042593,GO:0042802,GO:0046326,GO:0046872,GO:0055100,GO:0061042,GO:0061871,GO:0097003,GO:0120162" positive regulation of protein phosphorylation|protein binding|plasma membrane|lipid metabolic process|fatty acid metabolic process|hormone-mediated signaling pathway|negative regulation of gene expression|membrane|integral component of membrane|fatty acid oxidation|negative regulation of cell growth|intrinsic component of plasma membrane|adiponectin-activated signaling pathway|signaling receptor activity|glucose homeostasis|identical protein binding|positive regulation of glucose import|metal ion binding|adiponectin binding|vascular wound healing|negative regulation of hepatic stellate cell migration|adipokinetic hormone receptor activity|positive regulation of cold-induced thermogenesis "mmu04152,mmu04211,mmu04920,mmu04932" AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease Alpl 1.426373378 0.512351682 0.012677185 Up 3.114805757 2.953165663 2.020044486 3.555247849 3.75840714 4.063418889 "alkaline phosphatase, liver/bone/kidney" "GO:0001958,GO:0003006,GO:0003824,GO:0004035,GO:0005515,GO:0005615,GO:0005886,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016791,GO:0031012,GO:0031225,GO:0046677,GO:0046872,GO:0051384,GO:0065010,GO:0071407" endochondral ossification|developmental process involved in reproduction|catalytic activity|alkaline phosphatase activity|protein binding|extracellular space|plasma membrane|membrane|dephosphorylation|pyrophosphatase activity|hydrolase activity|phosphatase activity|extracellular matrix|anchored component of membrane|response to antibiotic|metal ion binding|response to glucocorticoid|extracellular membrane-bounded organelle|cellular response to organic cyclic compound "mmu00730,mmu00790" Thiamine metabolism|Folate biosynthesis Anln 1.227806177 0.296082833 0.003031842 Up 5.367939837 5.733343206 6.300279216 6.921329886 7.130049027 7.250025841 "anillin, actin binding protein" "GO:0000281,GO:0000915,GO:0002244,GO:0003779,GO:0005634,GO:0005654,GO:0005737,GO:0005826,GO:0005856,GO:0007049,GO:0015629,GO:0030496,GO:0031106,GO:0032059,GO:0042995,GO:0051301,GO:0090521,GO:0099738,GO:1904172" mitotic cytokinesis|actomyosin contractile ring assembly|hematopoietic progenitor cell differentiation|actin binding|nucleus|nucleoplasm|cytoplasm|actomyosin contractile ring|cytoskeleton|cell cycle|actin cytoskeleton|midbody|septin ring organization|bleb|cell projection|cell division|glomerular visceral epithelial cell migration|cell cortex region|positive regulation of bleb assembly Ano2 0.637702503 -0.649044551 0.015946601 Down 1.331392573 1.927363536 2.245151416 1.309241352 1.018101243 1.124854887 anoctamin 2 "GO:0005229,GO:0005254,GO:0005515,GO:0005654,GO:0005886,GO:0006811,GO:0006821,GO:0016020,GO:0016021,GO:0017128,GO:0034707,GO:0042802,GO:0046983,GO:0055085,GO:0097730,GO:1902476" intracellular calcium activated chloride channel activity|chloride channel activity|protein binding|nucleoplasm|plasma membrane|ion transport|chloride transport|membrane|integral component of membrane|phospholipid scramblase activity|chloride channel complex|identical protein binding|protein dimerization activity|transmembrane transport|non-motile cilium|chloride transmembrane transport mmu04740 Olfactory transduction Apaf1 0.798728509 -0.324222886 0.044781782 Down 2.414283136 2.97544576 3.184107617 2.258946831 2.23767204 2.303377698 apoptotic peptidase activating factor 1 "GO:0000166,GO:0001843,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0007275,GO:0007420,GO:0008635,GO:0008656,GO:0010659,GO:0030900,GO:0031072,GO:0032991,GO:0042802,GO:0042981,GO:0043293,GO:0043531,GO:0051402,GO:0070059,GO:0071560,GO:0097190,GO:1902510,GO:2001235" nucleotide binding|neural tube closure|ATP binding|nucleus|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|multicellular organism development|brain development|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|cysteine-type endopeptidase activator activity involved in apoptotic process|cardiac muscle cell apoptotic process|forebrain development|heat shock protein binding|protein-containing complex|identical protein binding|regulation of apoptotic process|apoptosome|ADP binding|neuron apoptotic process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to transforming growth factor beta stimulus|apoptotic signaling pathway|regulation of apoptotic DNA fragmentation|positive regulation of apoptotic signaling pathway "mmu01524,mmu04115,mmu04210,mmu04215,mmu05010,mmu05012,mmu05014,mmu05016,mmu05020,mmu05022,mmu05134,mmu05152,mmu05160,mmu05161,mmu05162,mmu05164,mmu05168,mmu05169,mmu05200,mmu05222,mmu05417" Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Legionellosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Small cell lung cancer|Lipid and atherosclerosis Apoc1 2.199259204 1.13701765 0.049767699 Up 1.386482129 1.882621011 0.854849507 3.513226617 2.756591814 2.517311367 apolipoprotein C-I "GO:0004859,GO:0005504,GO:0005576,GO:0006641,GO:0006869,GO:0008203,GO:0010916,GO:0032375,GO:0034361,GO:0034364,GO:0034447,GO:0042157,GO:0050995,GO:0051005" phospholipase inhibitor activity|fatty acid binding|extracellular region|triglyceride metabolic process|lipid transport|cholesterol metabolic process|negative regulation of very-low-density lipoprotein particle clearance|negative regulation of cholesterol transport|very-low-density lipoprotein particle|high-density lipoprotein particle|very-low-density lipoprotein particle clearance|lipoprotein metabolic process|negative regulation of lipid catabolic process|negative regulation of lipoprotein lipase activity mmu04979 Cholesterol metabolism Apol9a 0.093411564 -3.420255028 0.016937498 Down 0.158373423 0.282954976 0.298365 0 0.054289082 0.026624484 apolipoprotein L 9a GO:0008289 lipid binding Apol9b 0.233756685 -2.096920469 0.029025405 Down 0.196649027 0.231883993 0.424360777 0.040402033 0.060668674 0.099177227 apolipoprotein L 9b GO:0008289 lipid binding Apold1 0.63977977 -0.644352721 0.017029648 Down 2.572844731 2.12285161 1.570289938 1.489683492 1.202658552 1.258258219 apolipoprotein L domain containing 1 "GO:0001525,GO:0008289,GO:0045601" angiogenesis|lipid binding|regulation of endothelial cell differentiation Arhgef19 1.292104372 0.369722611 0.032057161 Up 4.317369378 3.436198138 2.995429238 3.941142463 4.903434027 4.950945803 Rho guanine nucleotide exchange factor (GEF) 19 "GO:0005085,GO:0005096,GO:0032956,GO:0042060,GO:0043547,GO:0090630" guanyl-nucleotide exchange factor activity|GTPase activator activity|regulation of actin cytoskeleton organization|wound healing|positive regulation of GTPase activity|activation of GTPase activity Arl4d 0.624675693 -0.678820702 9.35E-07 Down 18.08192072 20.85308557 22.12203169 10.50546413 12.87931859 14.91240843 ADP-ribosylation factor-like 4D "GO:0000166,GO:0005525,GO:0005634,GO:0005737,GO:0005886,GO:0006886,GO:0016020,GO:0016192" nucleotide binding|GTP binding|nucleus|cytoplasm|plasma membrane|intracellular protein transport|membrane|vesicle-mediated transport Asb4 1.779230367 0.831253317 0.048094751 Up 0.33892672 0.900407517 0.378566448 0.968811689 1.045631145 0.668868344 ankyrin repeat and SOCS box-containing 4 "GO:0004842,GO:0019899,GO:0031462,GO:0031466,GO:0031625,GO:0035556,GO:0051865,GO:0061630,GO:2001214" ubiquitin-protein transferase activity|enzyme binding|Cul2-RING ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|ubiquitin protein ligase binding|intracellular signal transduction|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of vasculogenesis Atp10a 0.672343244 -0.572730151 0.003301851 Down 2.327609393 1.802515247 3.127806004 1.575384478 1.569084857 1.62539685 "ATPase, class V, type 10A" "GO:0000166,GO:0000287,GO:0005524,GO:0005783,GO:0005886,GO:0005887,GO:0006869,GO:0015914,GO:0016020,GO:0016021,GO:0045332,GO:0046872,GO:0140326,GO:0140345,GO:0140351,GO:1903527,GO:1990531" nucleotide binding|magnesium ion binding|ATP binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|lipid transport|phospholipid transport|membrane|integral component of membrane|phospholipid translocation|metal ion binding|ATPase-coupled intramembrane lipid transporter activity|phosphatidylcholine flippase activity|glycosylceramide flippase activity|positive regulation of membrane tubulation|phospholipid-translocating ATPase complex B2m 0.701056189 -0.512398015 0.037126758 Down 169.378345 154.1873768 106.2840746 94.47775303 95.9917015 105.2895959 beta-2 microglobulin "GO:0001916,GO:0002237,GO:0002376,GO:0002474,GO:0002481,GO:0002726,GO:0003254,GO:0005515,GO:0005576,GO:0005615,GO:0005794,GO:0005829,GO:0005886,GO:0006826,GO:0006955,GO:0006968,GO:0007275,GO:0007611,GO:0009897,GO:0010977,GO:0019731,GO:0019885,GO:0030670,GO:0032092,GO:0033077,GO:0034756,GO:0042026,GO:0042612,GO:0042802,GO:0042803,GO:0042824,GO:0045087,GO:0045646,GO:0048260,GO:0050680,GO:0050768,GO:0050829,GO:0050830,GO:0051289,GO:0055072,GO:0061844,GO:0071222,GO:0071281,GO:0071283,GO:0071316,GO:0090647,GO:1900121,GO:1900122,GO:1904434,GO:1904437,GO:1990000,GO:1990712,GO:2000774,GO:2000978" "positive regulation of T cell mediated cytotoxicity|response to molecule of bacterial origin|immune system process|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|positive regulation of T cell cytokine production|regulation of membrane depolarization|protein binding|extracellular region|extracellular space|Golgi apparatus|cytosol|plasma membrane|iron ion transport|immune response|cellular defense response|multicellular organism development|learning or memory|external side of plasma membrane|negative regulation of neuron projection development|antibacterial humoral response|antigen processing and presentation of endogenous peptide antigen via MHC class I|phagocytic vesicle membrane|positive regulation of protein binding|T cell differentiation in thymus|regulation of iron ion transport|protein refolding|MHC class I protein complex|identical protein binding|protein homodimerization activity|MHC class I peptide loading complex|innate immune response|regulation of erythrocyte differentiation|positive regulation of receptor-mediated endocytosis|negative regulation of epithelial cell proliferation|negative regulation of neurogenesis|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|protein homotetramerization|iron ion homeostasis|antimicrobial humoral immune response mediated by antimicrobial peptide|cellular response to lipopolysaccharide|cellular response to iron ion|cellular response to iron(III) ion|cellular response to nicotine|modulation of age-related behavioral decline|negative regulation of receptor binding|positive regulation of receptor binding|positive regulation of ferrous iron binding|positive regulation of transferrin receptor binding|amyloid fibril formation|HFE-transferrin receptor complex|positive regulation of cellular senescence|negative regulation of forebrain neuron differentiation" "mmu04612,mmu05163,mmu05166,mmu05168,mmu05169,mmu05170" Antigen processing and presentation|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection Baiap2l2 0.597412277 -0.74320121 0.040206874 Down 1.046418056 0.891638052 1.006369859 0.771756102 0.496666159 0.514214565 BAI1-associated protein 2-like 2 "GO:0005543,GO:0005654,GO:0005829,GO:0005886,GO:0007009,GO:0008289,GO:0012506,GO:0016020,GO:0030054,GO:0030838,GO:0031410,GO:0042802,GO:0044291,GO:0051017,GO:0051764,GO:0061024,GO:0071439,GO:2000251" phospholipid binding|nucleoplasm|cytosol|plasma membrane|plasma membrane organization|lipid binding|vesicle membrane|membrane|cell junction|positive regulation of actin filament polymerization|cytoplasmic vesicle|identical protein binding|cell-cell contact zone|actin filament bundle assembly|actin crosslink formation|membrane organization|clathrin complex|positive regulation of actin cytoskeleton reorganization Banp 0.776141208 -0.36560894 0.026055296 Down 5.18009593 6.266354482 7.18983717 4.397478197 4.883157012 5.079880565 BTG3 associated nuclear protein "GO:0002039,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0007049,GO:0007275,GO:0016604,GO:0034504,GO:0042177,GO:0042802,GO:0045893" "p53 binding|DNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|cell cycle|multicellular organism development|nuclear body|protein localization to nucleus|negative regulation of protein catabolic process|identical protein binding|positive regulation of transcription, DNA-templated" BC147527 0.132245458 -2.918709916 0.0246247 Down 0.168722921 0.120578287 0.144483076 0.072217802 0 0.01418218 cDNA sequence BC147527 Bst2 0.243583573 -2.037511252 3.95E-18 Down 20.47028756 14.60650004 17.64878656 4.947848992 4.496990384 3.388031552 bone marrow stromal cell antigen 2 "GO:0002376,GO:0005737,GO:0005768,GO:0005794,GO:0005886,GO:0008191,GO:0009615,GO:0009986,GO:0016020,GO:0016021,GO:0016324,GO:0031225,GO:0032956,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0045087,GO:0051607,GO:1901253" immune system process|cytoplasm|endosome|Golgi apparatus|plasma membrane|metalloendopeptidase inhibitor activity|response to virus|cell surface|membrane|integral component of membrane|apical plasma membrane|anchored component of membrane|regulation of actin cytoskeleton organization|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|innate immune response|defense response to virus|negative regulation of intracellular transport of viral material "mmu05168,mmu05170" Herpes simplex virus 1 infection|Human immunodeficiency virus 1 infection Btbd16 0.439711087 -1.185372184 0.023133576 Down 0.519872149 0.703947831 0.421753163 0.323237853 0.281380759 0.137994924 BTB (POZ) domain containing 16 C1qc 0.80863948 -0.306431453 0.002636882 Down 55.22367383 50.97930695 45.44518136 40.31993277 41.86549461 39.95855785 "complement component 1, q subcomponent, C chain" "GO:0002376,GO:0005576,GO:0005581,GO:0005615,GO:0006958,GO:0030853,GO:0045087,GO:0045202,GO:0045650,GO:0098794,GO:0098883" "immune system process|extracellular region|collagen trimer|extracellular space|complement activation, classical pathway|negative regulation of granulocyte differentiation|innate immune response|synapse|negative regulation of macrophage differentiation|postsynapse|synapse pruning" "mmu04610,mmu05020,mmu05133,mmu05142,mmu05150,mmu05171,mmu05322" Complement and coagulation cascades|Prion disease|Pertussis|Chagas disease|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus C4b 0.73124279 -0.4515776 0.000890309 Down 7.303320779 5.643701304 4.708575747 4.447661805 4.548643813 3.75407176 complement component 4B (Chido blood group) "GO:0001848,GO:0001849,GO:0005576,GO:0005615,GO:0006956,GO:0016064,GO:0030246,GO:0030424,GO:0030425,GO:0043025,GO:0045202,GO:0106139" complement binding|complement component C1q complex binding|extracellular region|extracellular space|complement activation|immunoglobulin mediated immune response|carbohydrate binding|axon|dendrite|neuronal cell body|synapse|symbiont cell surface "mmu04610,mmu05133,mmu05150,mmu05171,mmu05322" Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus Cables1 0.805821681 -0.311467472 0.014123707 Down 8.639239409 8.834153967 9.664711963 7.332697094 7.057093417 7.431759332 CDK5 and Abl enzyme substrate 1 "GO:0000082,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0007399,GO:0042995,GO:0051301,GO:0051726" G1/S transition of mitotic cell cycle|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell cycle|nervous system development|cell projection|cell division|regulation of cell cycle Cacng5 0.82524465 -0.277106215 0.049348082 Down 7.960600633 6.178367912 4.420939929 6.340547215 4.203584844 4.586892327 "calcium channel, voltage-dependent, gamma subunit 5" "GO:0005245,GO:0005886,GO:0006816,GO:0014069,GO:0016020,GO:0016021,GO:0016247,GO:0019226,GO:0030054,GO:0032281,GO:0045202,GO:0045211,GO:0051968,GO:0098839,GO:0098943,GO:0098962,GO:0098970,GO:0098978,GO:0099055,GO:0099590,GO:2000311" "voltage-gated calcium channel activity|plasma membrane|calcium ion transport|postsynaptic density|membrane|integral component of membrane|channel regulator activity|transmission of nerve impulse|cell junction|AMPA glutamate receptor complex|synapse|postsynaptic membrane|positive regulation of synaptic transmission, glutamatergic|postsynaptic density membrane|neurotransmitter receptor transport, postsynaptic endosome to lysosome|regulation of postsynaptic neurotransmitter receptor activity|postsynaptic neurotransmitter receptor diffusion trapping|glutamatergic synapse|integral component of postsynaptic membrane|neurotransmitter receptor internalization|regulation of AMPA receptor activity" "mmu04010,mmu04260,mmu04261,mmu04921,mmu05410,mmu05412,mmu05414" MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy Car12 1.221710258 0.288902175 0.025680506 Up 4.296682239 4.586559701 3.606579348 4.915602112 5.63720331 4.662412373 carbonic anhydrase 12 "GO:0004089,GO:0005886,GO:0006730,GO:0006885,GO:0008270,GO:0015670,GO:0016020,GO:0016021,GO:0016829,GO:0016836,GO:0046872,GO:0055064" carbonate dehydratase activity|plasma membrane|one-carbon metabolic process|regulation of pH|zinc ion binding|carbon dioxide transport|membrane|integral component of membrane|lyase activity|hydro-lyase activity|metal ion binding|chloride ion homeostasis mmu00910 Nitrogen metabolism Car2 1.228553744 0.296960971 0.000175525 Up 109.3581905 109.7865305 89.29579494 116.9055552 132.0161566 128.37268 carbonic anhydrase 2 "GO:0002009,GO:0004064,GO:0004089,GO:0005615,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0006730,GO:0006885,GO:0008270,GO:0015670,GO:0016020,GO:0016323,GO:0016829,GO:0016836,GO:0030424,GO:0032230,GO:0032849,GO:0038166,GO:0043209,GO:0044070,GO:0045177,GO:0045672,GO:0045780,GO:0046872,GO:0046903,GO:0051453,GO:2001150,GO:2001225" "morphogenesis of an epithelium|arylesterase activity|carbonate dehydratase activity|extracellular space|cytoplasm|cytosol|plasma membrane|microvillus|one-carbon metabolic process|regulation of pH|zinc ion binding|carbon dioxide transport|membrane|basolateral plasma membrane|lyase activity|hydro-lyase activity|axon|positive regulation of synaptic transmission, GABAergic|positive regulation of cellular pH reduction|angiotensin-activated signaling pathway|myelin sheath|regulation of anion transport|apical part of cell|positive regulation of osteoclast differentiation|positive regulation of bone resorption|metal ion binding|secretion|regulation of intracellular pH|positive regulation of dipeptide transmembrane transport|regulation of chloride transport" "mmu00910,mmu04964,mmu04966,mmu04971,mmu04972,mmu04976" Nitrogen metabolism|Proximal tubule bicarbonate reclamation|Collecting duct acid secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion Cartpt 1.848239285 0.88615155 0.007026866 Up 10.82670883 14.61729235 12.08773485 14.78908344 42.18851063 19.18484282 CART prepropeptide "GO:0000186,GO:0001678,GO:0005184,GO:0005576,GO:0005615,GO:0007186,GO:0007218,GO:0007268,GO:0008343,GO:0009267,GO:0030141,GO:0032099,GO:0032812,GO:0032922,GO:0045671,GO:0045777,GO:0045779,GO:0046850,GO:0050796,GO:0051971,GO:0070093,GO:0070253" activation of MAPKK activity|cellular glucose homeostasis|neuropeptide hormone activity|extracellular region|extracellular space|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|adult feeding behavior|cellular response to starvation|secretory granule|negative regulation of appetite|positive regulation of epinephrine secretion|circadian regulation of gene expression|negative regulation of osteoclast differentiation|positive regulation of blood pressure|negative regulation of bone resorption|regulation of bone remodeling|regulation of insulin secretion|positive regulation of transmission of nerve impulse|negative regulation of glucagon secretion|somatostatin secretion Cbln4 1.267984225 0.342536797 0.013954104 Up 7.830214377 7.609355813 7.294335722 8.551114136 10.36651855 9.946466039 cerebellin 4 precursor protein "GO:0005515,GO:0005576,GO:0005615,GO:0009306,GO:0030054,GO:0045202,GO:0098982,GO:1904862" protein binding|extracellular region|extracellular space|protein secretion|cell junction|synapse|GABA-ergic synapse|inhibitory synapse assembly Ccdc190 1.258874524 0.332134492 0.038149297 Up 5.692314645 7.884942951 5.969781612 7.339456262 9.322771425 7.797344449 coiled-coil domain containing 190 Ccl28 3.240962683 1.69642241 0.035782467 Up 0.096006387 1.106355944 0.110988195 0.825973977 1.172425326 0.44788036 chemokine (C-C motif) ligand 28 "GO:0001954,GO:0005125,GO:0005576,GO:0005615,GO:0006935,GO:0006955,GO:0007204,GO:0008009,GO:0030141,GO:0031640,GO:0051715,GO:0060326,GO:0061844,GO:1903237" positive regulation of cell-matrix adhesion|cytokine activity|extracellular region|extracellular space|chemotaxis|immune response|positive regulation of cytosolic calcium ion concentration|chemokine activity|secretory granule|killing of cells of other organism|cytolysis in other organism|cell chemotaxis|antimicrobial humoral immune response mediated by antimicrobial peptide|negative regulation of leukocyte tethering or rolling "mmu04060,mmu04061,mmu04062,mmu04672" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Intestinal immune network for IgA production Ccn2 0.792804051 -0.334963761 0.009388871 Down 15.40697253 16.72154397 17.5840413 15.03893808 11.11062315 13.41262419 cellular communication network factor 2 "GO:0001502,GO:0001503,GO:0001525,GO:0001894,GO:0001934,GO:0001968,GO:0005178,GO:0005520,GO:0005576,GO:0005615,GO:0005801,GO:0005829,GO:0005938,GO:0007155,GO:0007160,GO:0007165,GO:0007229,GO:0008022,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0010628,GO:0010629,GO:0010942,GO:0016477,GO:0030154,GO:0030324,GO:0031012,GO:0032330,GO:0032967,GO:0035556,GO:0035988,GO:0043280,GO:0045597,GO:0046330,GO:0048471,GO:0050867,GO:0051496,GO:0060401,GO:0060452,GO:0060548,GO:0061448,GO:0070278,GO:0070318,GO:0070374,GO:0071897,GO:0072593" cartilage condensation|ossification|angiogenesis|tissue homeostasis|positive regulation of protein phosphorylation|fibronectin binding|integrin binding|insulin-like growth factor binding|extracellular region|extracellular space|cis-Golgi network|cytosol|cell cortex|cell adhesion|cell-matrix adhesion|signal transduction|integrin-mediated signaling pathway|protein C-terminus binding|growth factor activity|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell death|cell migration|cell differentiation|lung development|extracellular matrix|regulation of chondrocyte differentiation|positive regulation of collagen biosynthetic process|intracellular signal transduction|chondrocyte proliferation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of cell differentiation|positive regulation of JNK cascade|perinuclear region of cytoplasm|positive regulation of cell activation|positive regulation of stress fiber assembly|cytosolic calcium ion transport|positive regulation of cardiac muscle contraction|negative regulation of cell death|connective tissue development|extracellular matrix constituent secretion|positive regulation of G0 to G1 transition|positive regulation of ERK1 and ERK2 cascade|DNA biosynthetic process|reactive oxygen species metabolic process "mmu04371,mmu04390" Apelin signaling pathway|Hippo signaling pathway Ccn4 0.626061598 -0.675623485 0.045772269 Down 0.957147788 0.993296309 0.64873447 0.753121534 0.481682008 0.41082919 cellular communication network factor 4 "GO:0001649,GO:0001817,GO:0005178,GO:0005520,GO:0005576,GO:0005615,GO:0005737,GO:0005829,GO:0007155,GO:0007165,GO:0008201,GO:0014911,GO:0016055,GO:0030177,GO:0030316,GO:0031012,GO:0032331,GO:0042593,GO:0045599,GO:0045669,GO:0048661,GO:0050729,GO:0060348,GO:0060548,GO:0061051,GO:0090303" osteoblast differentiation|regulation of cytokine production|integrin binding|insulin-like growth factor binding|extracellular region|extracellular space|cytoplasm|cytosol|cell adhesion|signal transduction|heparin binding|positive regulation of smooth muscle cell migration|Wnt signaling pathway|positive regulation of Wnt signaling pathway|osteoclast differentiation|extracellular matrix|negative regulation of chondrocyte differentiation|glucose homeostasis|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of inflammatory response|bone development|negative regulation of cell death|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of wound healing mmu04310 Wnt signaling pathway Cd274 0.526399321 -0.925770466 0.005951068 Down 1.101234551 1.019523011 1.285941747 0.719890773 0.437549832 0.656372921 CD274 antigen "GO:0002250,GO:0002376,GO:0002845,GO:0005515,GO:0005654,GO:0005768,GO:0005886,GO:0006955,GO:0007165,GO:0007166,GO:0009897,GO:0009986,GO:0015629,GO:0016020,GO:0016021,GO:0030335,GO:0031295,GO:0031901,GO:0032689,GO:0032693,GO:0032733,GO:0034097,GO:0042102,GO:0042130,GO:0046007,GO:0055038,GO:0070062,GO:0071222,GO:1901998,GO:1903556,GO:1905404,GO:2000562,GO:2001186" "adaptive immune response|immune system process|positive regulation of tolerance induction to tumor cell|protein binding|nucleoplasm|endosome|plasma membrane|immune response|signal transduction|cell surface receptor signaling pathway|external side of plasma membrane|cell surface|actin cytoskeleton|membrane|integral component of membrane|positive regulation of cell migration|T cell costimulation|early endosome membrane|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|positive regulation of interleukin-10 production|response to cytokine|positive regulation of T cell proliferation|negative regulation of T cell proliferation|negative regulation of activated T cell proliferation|recycling endosome membrane|extracellular exosome|cellular response to lipopolysaccharide|toxin transport|negative regulation of tumor necrosis factor superfamily cytokine production|positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process|negative regulation of CD4-positive, alpha-beta T cell proliferation|negative regulation of CD8-positive, alpha-beta T cell activation" "mmu04514,mmu05235" Cell adhesion molecules|PD-L1 expression and PD-1 checkpoint pathway in cancer Cdc42ep1 1.211590405 0.276902059 0.039833441 Up 12.55004498 10.5597194 8.590718162 13.01635259 12.26395051 12.69952299 CDC42 effector protein (Rho GTPase binding) 1 "GO:0005515,GO:0005737,GO:0005856,GO:0005886,GO:0007266,GO:0008360,GO:0016020,GO:0030838,GO:0031274" protein binding|cytoplasm|cytoskeleton|plasma membrane|Rho protein signal transduction|regulation of cell shape|membrane|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly Cdhr1 0.411508671 -1.281005264 0.003186749 Down 15.09084633 7.576282463 2.8492795 6.351199613 1.771525284 2.011314166 cadherin-related family member 1 "GO:0005509,GO:0005515,GO:0005886,GO:0005887,GO:0007155,GO:0007156,GO:0008594,GO:0009987,GO:0016020,GO:0016021,GO:0035845,GO:0042622,GO:0045494" calcium ion binding|protein binding|plasma membrane|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|photoreceptor cell morphogenesis|cellular process|membrane|integral component of membrane|photoreceptor cell outer segment organization|photoreceptor outer segment membrane|photoreceptor cell maintenance Cdkn1a 0.617768423 -0.694861964 6.11E-06 Down 10.41250803 10.08353694 12.58659066 6.304145929 6.750671309 7.306302539 cyclin-dependent kinase inhibitor 1A (P21) "GO:0000079,GO:0000082,GO:0000086,GO:0000307,GO:0004860,GO:0004861,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006606,GO:0006974,GO:0006977,GO:0006978,GO:0007049,GO:0007095,GO:0007346,GO:0007507,GO:0008285,GO:0009411,GO:0010629,GO:0010942,GO:0016604,GO:0019901,GO:0019912,GO:0030308,GO:0030332,GO:0030890,GO:0031625,GO:0031668,GO:0032091,GO:0032991,GO:0034198,GO:0042060,GO:0042246,GO:0042326,GO:0042771,GO:0043066,GO:0043068,GO:0044877,GO:0045736,GO:0045860,GO:0046872,GO:0048146,GO:0048471,GO:0051726,GO:0070557,GO:0071479,GO:0071480,GO:0071493,GO:0072331,GO:0090398,GO:0140311,GO:1902806,GO:1904030,GO:1904706,GO:1905179,GO:2000134,GO:2000278,GO:2000279,GO:2000379" "regulation of cyclin-dependent protein serine/threonine kinase activity|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|cyclin-dependent protein kinase holoenzyme complex|protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein import into nucleus|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle|mitotic G2 DNA damage checkpoint signaling|regulation of mitotic cell cycle|heart development|negative regulation of cell population proliferation|response to UV|negative regulation of gene expression|positive regulation of cell death|nuclear body|protein kinase binding|cyclin-dependent protein kinase activating kinase activity|negative regulation of cell growth|cyclin binding|positive regulation of B cell proliferation|ubiquitin protein ligase binding|cellular response to extracellular stimulus|negative regulation of protein binding|protein-containing complex|cellular response to amino acid starvation|wound healing|tissue regeneration|negative regulation of phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of apoptotic process|positive regulation of programmed cell death|protein-containing complex binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of protein kinase activity|metal ion binding|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|regulation of cell cycle|PCNA-p21 complex|cellular response to ionizing radiation|cellular response to gamma radiation|cellular response to UV-B|signal transduction by p53 class mediator|cellular senescence|protein sequestering activity|regulation of cell cycle G1/S phase transition|negative regulation of cyclin-dependent protein kinase activity|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of cardiac muscle tissue regeneration|negative regulation of G1/S transition of mitotic cell cycle|regulation of DNA biosynthetic process|negative regulation of DNA biosynthetic process|positive regulation of reactive oxygen species metabolic process" "mmu01522,mmu01524,mmu04012,mmu04066,mmu04068,mmu04110,mmu04115,mmu04151,mmu04218,mmu04630,mmu04921,mmu04928,mmu04934,mmu05160,mmu05161,mmu05163,mmu05165,mmu05166,mmu05167,mmu05169,mmu05200,mmu05202,mmu05203,mmu05205,mmu05206,mmu05210,mmu05211,mmu05212,mmu05213,mmu05214,mmu05215,mmu05216,mmu05217,mmu05218,mmu05219,mmu05220,mmu05222,mmu05223,mmu05224,mmu05225,mmu05226" "Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|JAK-STAT signaling pathway|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer" Cebpd 0.60747733 -0.719097525 0.003158878 Down 3.376063535 3.546202092 4.749836375 2.374137881 2.283504467 2.354028535 "CCAAT/enhancer binding protein (C/EBP), delta" "GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0002244,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0042802,GO:0043565,GO:0045444,GO:0045595,GO:0045669,GO:0045892,GO:0045944,GO:0048839,GO:1990837" "transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|hematopoietic progenitor cell differentiation|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|identical protein binding|sequence-specific DNA binding|fat cell differentiation|regulation of cell differentiation|positive regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|inner ear development|sequence-specific double-stranded DNA binding" Ch25h 0.318656833 -1.649924496 0.014605761 Down 1.312049218 0.884078943 0.963044222 0.192545561 0.501160555 0.340310029 cholesterol 25-hydroxylase "GO:0000254,GO:0001567,GO:0004497,GO:0005506,GO:0005783,GO:0005789,GO:0006629,GO:0006694,GO:0008202,GO:0008203,GO:0008395,GO:0008610,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0035754,GO:0046872" C-4 methylsterol oxidase activity|cholesterol 25-hydroxylase activity|monooxygenase activity|iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|lipid metabolic process|steroid biosynthetic process|steroid metabolic process|cholesterol metabolic process|steroid hydroxylase activity|lipid biosynthetic process|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|B cell chemotaxis|metal ion binding mmu00120 Primary bile acid biosynthesis Chdh 1.421309029 0.507220267 0.029818406 Up 0.999635336 1.024997314 0.982563401 1.410854635 1.510712807 1.350251398 choline dehydrogenase "GO:0005739,GO:0005743,GO:0008812,GO:0016020,GO:0016491,GO:0016614,GO:0019285,GO:0050660" "mitochondrion|mitochondrial inner membrane|choline dehydrogenase activity|membrane|oxidoreductase activity|oxidoreductase activity, acting on CH-OH group of donors|glycine betaine biosynthetic process from choline|flavin adenine dinucleotide binding" mmu00260 "Glycine, serine and threonine metabolism" Chrm4 0.755308615 -0.404861854 0.000355296 Down 11.5768439 11.16019218 12.33855704 9.083327691 8.864763912 8.49890497 "cholinergic receptor, muscarinic 4" "GO:0004930,GO:0004993,GO:0005085,GO:0005737,GO:0005886,GO:0005887,GO:0007165,GO:0007186,GO:0007187,GO:0007197,GO:0007268,GO:0014069,GO:0016020,GO:0016021,GO:0016907,GO:0030054,GO:0030425,GO:0030594,GO:0032279,GO:0040012,GO:0042383,GO:0043025,GO:0043679,GO:0045202,GO:0045211,GO:0098978,GO:0099056,GO:0099061" "G protein-coupled receptor activity|G protein-coupled serotonin receptor activity|guanyl-nucleotide exchange factor activity|cytoplasm|plasma membrane|integral component of plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway|chemical synaptic transmission|postsynaptic density|membrane|integral component of membrane|G protein-coupled acetylcholine receptor activity|cell junction|dendrite|neurotransmitter receptor activity|asymmetric synapse|regulation of locomotion|sarcolemma|neuronal cell body|axon terminus|synapse|postsynaptic membrane|glutamatergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane" "mmu04080,mmu04725,mmu04810" Neuroactive ligand-receptor interaction|Cholinergic synapse|Regulation of actin cytoskeleton Chrna3 2.448701212 1.292016749 0.001111309 Up 0.376525049 0.504533688 0.217640913 0.773580106 1.040623894 0.783317783 "cholinergic receptor, nicotinic, alpha polypeptide 3" "GO:0004888,GO:0005216,GO:0005230,GO:0005515,GO:0005886,GO:0005887,GO:0005892,GO:0006811,GO:0006937,GO:0006940,GO:0007165,GO:0007171,GO:0007268,GO:0007271,GO:0007399,GO:0007626,GO:0014056,GO:0014069,GO:0015464,GO:0016020,GO:0016021,GO:0022848,GO:0030054,GO:0030425,GO:0030594,GO:0032991,GO:0034220,GO:0035095,GO:0042166,GO:0042391,GO:0042493,GO:0043005,GO:0043025,GO:0044853,GO:0044877,GO:0045202,GO:0045211,GO:0048814,GO:0050877,GO:0060079,GO:0060084,GO:0095500,GO:0098691,GO:0098981,GO:0099060,GO:1904315,GO:1905144,GO:2000300" "transmembrane signaling receptor activity|ion channel activity|extracellular ligand-gated ion channel activity|protein binding|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|ion transport|regulation of muscle contraction|regulation of smooth muscle contraction|signal transduction|activation of transmembrane receptor protein tyrosine kinase activity|chemical synaptic transmission|synaptic transmission, cholinergic|nervous system development|locomotory behavior|regulation of acetylcholine secretion, neurotransmission|postsynaptic density|acetylcholine receptor activity|membrane|integral component of membrane|acetylcholine-gated cation-selective channel activity|cell junction|dendrite|neurotransmitter receptor activity|protein-containing complex|ion transmembrane transport|behavioral response to nicotine|acetylcholine binding|regulation of membrane potential|response to drug|neuron projection|neuronal cell body|plasma membrane raft|protein-containing complex binding|synapse|postsynaptic membrane|regulation of dendrite morphogenesis|nervous system process|excitatory postsynaptic potential|synaptic transmission involved in micturition|acetylcholine receptor signaling pathway|dopaminergic synapse|cholinergic synapse|integral component of postsynaptic specialization membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|response to acetylcholine|regulation of synaptic vesicle exocytosis" "mmu04080,mmu04725" Neuroactive ligand-receptor interaction|Cholinergic synapse Chrnb3 1.590887368 0.669831699 0.045503685 Up 0.695272978 0.461387359 0.771165963 0.816260387 1.07817648 1.146574243 "cholinergic receptor, nicotinic, beta polypeptide 3" "GO:0004888,GO:0005216,GO:0005230,GO:0005886,GO:0005887,GO:0005892,GO:0006811,GO:0007165,GO:0007268,GO:0007271,GO:0015464,GO:0016020,GO:0016021,GO:0022848,GO:0030054,GO:0030594,GO:0032991,GO:0034220,GO:0035094,GO:0042166,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050877,GO:0098691,GO:2000300" "transmembrane signaling receptor activity|ion channel activity|extracellular ligand-gated ion channel activity|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|ion transport|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|acetylcholine receptor activity|membrane|integral component of membrane|acetylcholine-gated cation-selective channel activity|cell junction|neurotransmitter receptor activity|protein-containing complex|ion transmembrane transport|response to nicotine|acetylcholine binding|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|nervous system process|dopaminergic synapse|regulation of synaptic vesicle exocytosis" mmu04080 Neuroactive ligand-receptor interaction Ciart 0.672318609 -0.572783013 0.003522668 Down 5.720894924 5.993826181 8.119388486 4.790195864 4.329165169 4.072019595 circadian associated repressor of transcription "GO:0000976,GO:0000978,GO:0005515,GO:0005634,GO:0032922,GO:0045475,GO:0045892,GO:0048511,GO:0070888" "transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|protein binding|nucleus|circadian regulation of gene expression|locomotor rhythm|negative regulation of transcription, DNA-templated|rhythmic process|E-box binding" Cldn11 0.832445861 -0.264571646 3.90E-05 Down 152.8289428 145.0918144 145.0724466 120.2123649 128.2753556 119.8579677 claudin 11 "GO:0005198,GO:0005515,GO:0005811,GO:0005883,GO:0005886,GO:0005887,GO:0005923,GO:0007155,GO:0007283,GO:0008366,GO:0016020,GO:0016021,GO:0030054,GO:0030424,GO:0042802,GO:0043209,GO:0045178,GO:0070160,GO:0070830,GO:0120192" structural molecule activity|protein binding|lipid droplet|neurofilament|plasma membrane|integral component of plasma membrane|bicellular tight junction|cell adhesion|spermatogenesis|axon ensheathment|membrane|integral component of membrane|cell junction|axon|identical protein binding|myelin sheath|basal part of cell|tight junction|bicellular tight junction assembly|tight junction assembly "mmu04514,mmu04530,mmu04670,mmu05160" Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Hepatitis C Clk1 0.825929515 -0.275909429 0.024082702 Down 16.31361643 20.87743859 23.08986407 15.34985836 15.2801515 18.8542087 CDC-like kinase 1 "GO:0000166,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0016301,GO:0016310,GO:0016740,GO:0018105,GO:0018107,GO:0018108,GO:0043484,GO:0046777" nucleotide binding|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|kinase activity|phosphorylation|transferase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|regulation of RNA splicing|protein autophosphorylation mmu05134 Legionellosis Cmpk2 0.824620058 -0.278198541 0.020764215 Down 9.971715122 10.93045577 13.03555399 8.758993556 9.329925106 9.734258838 "cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial" "GO:0000166,GO:0004127,GO:0004550,GO:0004798,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0006165,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0009041,GO:0009142,GO:0016301,GO:0016740,GO:0033862,GO:0050145,GO:0071222" nucleotide binding|cytidylate kinase activity|nucleoside diphosphate kinase activity|thymidylate kinase activity|ATP binding|nucleoplasm|cytoplasm|mitochondrion|nucleoside diphosphate phosphorylation|pyrimidine nucleotide biosynthetic process|dUDP biosynthetic process|dTDP biosynthetic process|dTTP biosynthetic process|uridylate kinase activity|nucleoside triphosphate biosynthetic process|kinase activity|transferase activity|UMP kinase activity|nucleoside monophosphate kinase activity|cellular response to lipopolysaccharide mmu00240 Pyrimidine metabolism Cmtm3 0.730707512 -0.452634056 0.037282368 Down 3.834745278 3.425638717 5.094897313 2.765461104 3.126960754 3.027981272 CKLF-like MARVEL transmembrane domain containing 3 "GO:0001835,GO:0005125,GO:0005515,GO:0005615,GO:0005737,GO:0005829,GO:0006935,GO:0016020,GO:0016021,GO:0031410,GO:0031965,GO:0050861" blastocyst hatching|cytokine activity|protein binding|extracellular space|cytoplasm|cytosol|chemotaxis|membrane|integral component of membrane|cytoplasmic vesicle|nuclear membrane|positive regulation of B cell receptor signaling pathway Ctxn2 1.321486265 0.402161431 0.049513375 Up 7.209707072 7.976367967 7.171237529 9.590159142 9.505489014 10.39556361 cortexin 2 "GO:0016020,GO:0016021" membrane|integral component of membrane Cxcl10 0.262613529 -1.928986856 0.028615412 Down 0.744158498 1.196583439 0.477935843 0.382223049 0.191318471 0.093826521 chemokine (C-X-C motif) ligand 10 "GO:0002690,GO:0005125,GO:0005576,GO:0005615,GO:0006935,GO:0006952,GO:0006954,GO:0006955,GO:0007186,GO:0007189,GO:0008009,GO:0008201,GO:0008284,GO:0009617,GO:0009897,GO:0010818,GO:0010819,GO:0016525,GO:0030335,GO:0030593,GO:0031640,GO:0042056,GO:0042118,GO:0042127,GO:0042981,GO:0045236,GO:0045662,GO:0048248,GO:0051281,GO:0051607,GO:0061844,GO:0070098,GO:0071222,GO:0090026,GO:1901509,GO:1901740,GO:2000406" positive regulation of leukocyte chemotaxis|cytokine activity|extracellular region|extracellular space|chemotaxis|defense response|inflammatory response|immune response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|chemokine activity|heparin binding|positive regulation of cell population proliferation|response to bacterium|external side of plasma membrane|T cell chemotaxis|regulation of T cell chemotaxis|negative regulation of angiogenesis|positive regulation of cell migration|neutrophil chemotaxis|killing of cells of other organism|chemoattractant activity|endothelial cell activation|regulation of cell population proliferation|regulation of apoptotic process|CXCR chemokine receptor binding|negative regulation of myoblast differentiation|CXCR3 chemokine receptor binding|positive regulation of release of sequestered calcium ion into cytosol|defense response to virus|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide|positive regulation of monocyte chemotaxis|regulation of endothelial tube morphogenesis|negative regulation of myoblast fusion|positive regulation of T cell migration "mmu04060,mmu04061,mmu04062,mmu04620,mmu04622,mmu04623,mmu04657,mmu04668,mmu05160,mmu05164,mmu05169,mmu05171" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|Toll-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|IL-17 signaling pathway|TNF signaling pathway|Hepatitis C|Influenza A|Epstein-Barr virus infection|Coronavirus disease - COVID-19 Cxcl12 1.227248538 0.295427448 0.006372015 Up 12.01346783 9.336684414 8.318206046 11.9222727 11.36894184 12.70911085 chemokine (C-X-C motif) ligand 12 "GO:0001569,GO:0001667,GO:0001764,GO:0001938,GO:0005125,GO:0005178,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005886,GO:0006935,GO:0006952,GO:0006955,GO:0007281,GO:0007411,GO:0007420,GO:0008009,GO:0008045,GO:0008083,GO:0008284,GO:0008285,GO:0008344,GO:0008354,GO:0009897,GO:0010818,GO:0022029,GO:0030334,GO:0030335,GO:0031100,GO:0031640,GO:0033603,GO:0033622,GO:0038146,GO:0042098,GO:0042379,GO:0045236,GO:0045666,GO:0045785,GO:0048842,GO:0050921,GO:0050930,GO:0050965,GO:0050966,GO:0051897,GO:0051924,GO:0060326,GO:0061844,GO:0070098,GO:0070374,GO:0071542,GO:0090026,GO:0090280,GO:0098609,GO:1901741,GO:1902230,GO:1903237,GO:1990869,GO:2000406,GO:2000669" branching involved in blood vessel morphogenesis|ameboidal-type cell migration|neuron migration|positive regulation of endothelial cell proliferation|cytokine activity|integrin binding|extracellular region|extracellular space|nucleus|cytoplasm|plasma membrane|chemotaxis|defense response|immune response|germ cell development|axon guidance|brain development|chemokine activity|motor neuron axon guidance|growth factor activity|positive regulation of cell population proliferation|negative regulation of cell population proliferation|adult locomotory behavior|germ cell migration|external side of plasma membrane|T cell chemotaxis|telencephalon cell migration|regulation of cell migration|positive regulation of cell migration|animal organ regeneration|killing of cells of other organism|positive regulation of dopamine secretion|integrin activation|chemokine (C-X-C motif) ligand 12 signaling pathway|T cell proliferation|chemokine receptor binding|CXCR chemokine receptor binding|positive regulation of neuron differentiation|positive regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of chemotaxis|induction of positive chemotaxis|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|positive regulation of protein kinase B signaling|regulation of calcium ion transport|cell chemotaxis|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|dopaminergic neuron differentiation|positive regulation of monocyte chemotaxis|positive regulation of calcium ion import|cell-cell adhesion|positive regulation of myoblast fusion|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of leukocyte tethering or rolling|cellular response to chemokine|positive regulation of T cell migration|negative regulation of dendritic cell apoptotic process "mmu04060,mmu04061,mmu04062,mmu04064,mmu04360,mmu04670,mmu04672,mmu04810,mmu05163,mmu05200,mmu05323" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|NF-kappa B signaling pathway|Axon guidance|Leukocyte transendothelial migration|Intestinal immune network for IgA production|Regulation of actin cytoskeleton|Human cytomegalovirus infection|Pathways in cancer|Rheumatoid arthritis D17H6S56E-5 0.523779451 -0.932968634 0.011483025 Down 1.321187538 0.944190209 1.498099254 0.561602639 0.780848297 0.612710556 "DNA segment, Chr 17, human D6S56E 5" Ddit4 0.722207273 -0.469515145 4.37E-05 Down 32.27434175 28.66829284 42.0341312 22.41500004 24.9707222 26.1782676 DNA-damage-inducible transcript 4 "GO:0001666,GO:0001764,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0007420,GO:0009968,GO:0010801,GO:0030182,GO:0032006,GO:0032007,GO:0032984,GO:0033137,GO:0042771,GO:0045820,GO:0048011,GO:0051607,GO:0071549,GO:0071889,GO:0072593,GO:1901216,GO:1902532" response to hypoxia|neuron migration|cytoplasm|mitochondrion|cytosol|apoptotic process|brain development|negative regulation of signal transduction|negative regulation of peptidyl-threonine phosphorylation|neuron differentiation|regulation of TOR signaling|negative regulation of TOR signaling|protein-containing complex disassembly|negative regulation of peptidyl-serine phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of glycolytic process|neurotrophin TRK receptor signaling pathway|defense response to virus|cellular response to dexamethasone stimulus|14-3-3 protein binding|reactive oxygen species metabolic process|positive regulation of neuron death|negative regulation of intracellular signal transduction "mmu04140,mmu04150,mmu04151,mmu05206" Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|MicroRNAs in cancer Ddx58 0.419892995 -1.251906374 2.91E-07 Down 2.102144297 1.86492792 3.798908566 0.936117968 1.096869998 1.086300503 DEAD/H box helicase 58 "GO:0000166,GO:0002230,GO:0002376,GO:0002735,GO:0003677,GO:0003690,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0004386,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005923,GO:0008270,GO:0009597,GO:0009615,GO:0010628,GO:0015629,GO:0016020,GO:0016787,GO:0030054,GO:0030334,GO:0031625,GO:0032587,GO:0032725,GO:0032727,GO:0032728,GO:0032755,GO:0032757,GO:0032760,GO:0039529,GO:0042802,GO:0042995,GO:0043330,GO:0045087,GO:0045944,GO:0046872,GO:0051091,GO:0051607,GO:0060760,GO:0071360,GO:0140374,GO:1990904" nucleotide binding|positive regulation of defense response to virus by host|immune system process|positive regulation of myeloid dendritic cell cytokine production|DNA binding|double-stranded DNA binding|RNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|helicase activity|protein binding|ATP binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|bicellular tight junction|zinc ion binding|detection of virus|response to virus|positive regulation of gene expression|actin cytoskeleton|membrane|hydrolase activity|cell junction|regulation of cell migration|ubiquitin protein ligase binding|ruffle membrane|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|RIG-I signaling pathway|identical protein binding|cell projection|response to exogenous dsRNA|innate immune response|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of DNA-binding transcription factor activity|defense response to virus|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA|antiviral innate immune response|ribonucleoprotein complex "mmu04064,mmu04622,mmu04623,mmu05160,mmu05161,mmu05162,mmu05164,mmu05168,mmu05169,mmu05171" NF-kappa B signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 Ddx60 0.407027897 -1.296800416 0.008640323 Down 0.34075437 0.272018163 0.357609421 0.134059472 0.126748826 0.131633442 DExD/H box helicase 60 "GO:0003690,GO:0003723,GO:0003725,GO:0003727,GO:0005515,GO:0005737,GO:0005829,GO:0009615,GO:0045111,GO:0051607,GO:1900245,GO:1900246" double-stranded DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|protein binding|cytoplasm|cytosol|response to virus|intermediate filament cytoskeleton|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway Dhx58 0.280674313 -1.833031056 2.01E-05 Down 1.358737158 1.115161691 2.159806341 0.436181154 0.392988128 0.428287727 DEXH (Asp-Glu-X-His) box polypeptide 58 "GO:0000166,GO:0002376,GO:0003677,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0004386,GO:0005524,GO:0005737,GO:0008270,GO:0009615,GO:0009617,GO:0016787,GO:0032480,GO:0032481,GO:0032728,GO:0039534,GO:0039536,GO:0045087,GO:0045088,GO:0045824,GO:0046872,GO:0051607,GO:1900245,GO:1900246" nucleotide binding|immune system process|DNA binding|RNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|helicase activity|ATP binding|cytoplasm|zinc ion binding|response to virus|response to bacterium|hydrolase activity|negative regulation of type I interferon production|positive regulation of type I interferon production|positive regulation of interferon-beta production|negative regulation of MDA-5 signaling pathway|negative regulation of RIG-I signaling pathway|innate immune response|regulation of innate immune response|negative regulation of innate immune response|metal ion binding|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway mmu04622 RIG-I-like receptor signaling pathway Dlk1 1.276386667 0.352065444 0.006490049 Up 5.415963788 6.659593566 6.296591632 8.20360686 8.518274394 6.726906249 delta like non-canonical Notch ligand 1 "GO:0001503,GO:0001649,GO:0001819,GO:0005509,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0009790,GO:0009791,GO:0009897,GO:0010468,GO:0016020,GO:0016021,GO:0030154,GO:0030279,GO:0030282,GO:0035264,GO:0045599,GO:0045668,GO:0045672,GO:0045746,GO:0045780,GO:0046850,GO:0048706,GO:1905563" ossification|osteoblast differentiation|positive regulation of cytokine production|calcium ion binding|protein binding|extracellular space|cytoplasm|plasma membrane|embryo development|post-embryonic development|external side of plasma membrane|regulation of gene expression|membrane|integral component of membrane|cell differentiation|negative regulation of ossification|bone mineralization|multicellular organism growth|negative regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|negative regulation of Notch signaling pathway|positive regulation of bone resorption|regulation of bone remodeling|embryonic skeletal system development|negative regulation of vascular endothelial cell proliferation Dlx1 0.763182507 -0.389899992 0.004355034 Down 11.600921 9.215657671 6.27351844 8.14862807 6.135884384 5.990401042 distal-less homeobox 1 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0009790,GO:0009954,GO:0021544,GO:0021766,GO:0021879,GO:0021892,GO:0021893,GO:0030154,GO:0030514,GO:0042475,GO:0043524,GO:0045597,GO:0045746,GO:0045944,GO:0046533,GO:0048706,GO:0048715,GO:0071560,GO:0071773,GO:1902871,GO:1903845,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|chromatin binding|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|embryo development|proximal/distal pattern formation|subpallium development|hippocampus development|forebrain neuron differentiation|cerebral cortex GABAergic interneuron differentiation|cerebral cortex GABAergic interneuron fate commitment|cell differentiation|negative regulation of BMP signaling pathway|odontogenesis of dentin-containing tooth|negative regulation of neuron apoptotic process|positive regulation of cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|negative regulation of photoreceptor cell differentiation|embryonic skeletal system development|negative regulation of oligodendrocyte differentiation|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|positive regulation of amacrine cell differentiation|negative regulation of cellular response to transforming growth factor beta stimulus|sequence-specific double-stranded DNA binding" Dlx2 0.713445939 -0.48712398 0.015642409 Down 6.31551113 5.371682245 3.234270893 4.466932433 3.279297617 2.736088349 distal-less homeobox 2 "GO:0000122,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0003727,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0009790,GO:0009954,GO:0021544,GO:0021766,GO:0021772,GO:0021879,GO:0021892,GO:0021893,GO:0030154,GO:0042475,GO:0045597,GO:0045746,GO:0045944,GO:0046533,GO:0048701,GO:0048706,GO:0048715,GO:0048755,GO:0051216,GO:1902871,GO:1990837" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|single-stranded RNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|embryo development|proximal/distal pattern formation|subpallium development|hippocampus development|olfactory bulb development|forebrain neuron differentiation|cerebral cortex GABAergic interneuron differentiation|cerebral cortex GABAergic interneuron fate commitment|cell differentiation|odontogenesis of dentin-containing tooth|positive regulation of cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription by RNA polymerase II|negative regulation of photoreceptor cell differentiation|embryonic cranial skeleton morphogenesis|embryonic skeletal system development|negative regulation of oligodendrocyte differentiation|branching morphogenesis of a nerve|cartilage development|positive regulation of amacrine cell differentiation|sequence-specific double-stranded DNA binding" Dlx5 0.690724193 -0.533818338 0.030003921 Down 8.010838895 6.262671577 5.912442282 4.864795893 4.688005308 4.28569057 distal-less homeobox 5 "GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001503,GO:0001649,GO:0001958,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006357,GO:0007275,GO:0007409,GO:0007411,GO:0008283,GO:0009790,GO:0010628,GO:0021889,GO:0030154,GO:0030326,GO:0030509,GO:0030855,GO:0042472,GO:0043583,GO:0045669,GO:0045893,GO:0045944,GO:0048646,GO:0050679,GO:0060021,GO:0060166,GO:0060322,GO:0060325,GO:0060349,GO:0071773,GO:0071837,GO:0090263,GO:0097376,GO:1901522,GO:1990837" "chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|ossification|osteoblast differentiation|endochondral ossification|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|axonogenesis|axon guidance|cell population proliferation|embryo development|positive regulation of gene expression|olfactory bulb interneuron differentiation|cell differentiation|embryonic limb morphogenesis|BMP signaling pathway|epithelial cell differentiation|inner ear morphogenesis|ear development|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|anatomical structure formation involved in morphogenesis|positive regulation of epithelial cell proliferation|roof of mouth development|olfactory pit development|head development|face morphogenesis|bone morphogenesis|cellular response to BMP stimulus|HMG box domain binding|positive regulation of canonical Wnt signaling pathway|interneuron axon guidance|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|sequence-specific double-stranded DNA binding" mmu04550 Signaling pathways regulating pluripotency of stem cells Doc2g 0.390110914 -1.358043734 0.027105332 Down 22.13978068 11.82739645 3.126357275 8.058079954 2.148635162 2.846933065 "double C2, gamma" "GO:0016020,GO:0046872,GO:0061669" membrane|metal ion binding|spontaneous neurotransmitter secretion Dtx3l 0.726580117 -0.460806207 0.047324881 Down 1.531972212 1.5786714 2.092235414 1.299602632 1.189204375 1.256145336 "deltex 3-like, E3 ubiquitin ligase" "GO:0002230,GO:0002376,GO:0004842,GO:0004857,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005829,GO:0006281,GO:0006302,GO:0006325,GO:0006511,GO:0006974,GO:0007219,GO:0008047,GO:0008333,GO:0010390,GO:0015031,GO:0016020,GO:0016567,GO:0016740,GO:0019899,GO:0032092,GO:0032991,GO:0033522,GO:0033523,GO:0035563,GO:0042393,GO:0044389,GO:0045087,GO:0045893,GO:0046872,GO:0051444,GO:0051607,GO:0051865,GO:0061630,GO:0070936,GO:0097677,GO:1900182,GO:1901666,GO:1902966,GO:2000646,GO:2001034" "positive regulation of defense response to virus by host|immune system process|ubiquitin-protein transferase activity|enzyme inhibitor activity|nucleus|nucleoplasm|cytoplasm|lysosome|endosome|early endosome|cytosol|DNA repair|double-strand break repair|chromatin organization|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|Notch signaling pathway|enzyme activator activity|endosome to lysosome transport|histone monoubiquitination|protein transport|membrane|protein ubiquitination|transferase activity|enzyme binding|positive regulation of protein binding|protein-containing complex|histone H2A ubiquitination|histone H2B ubiquitination|positive regulation of chromatin binding|histone binding|ubiquitin-like protein ligase binding|innate immune response|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of ubiquitin-protein transferase activity|defense response to virus|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|STAT family protein binding|positive regulation of protein localization to nucleus|positive regulation of NAD+ ADP-ribosyltransferase activity|positive regulation of protein localization to early endosome|positive regulation of receptor catabolic process|positive regulation of double-strand break repair via nonhomologous end joining" mmu04330 Notch signaling pathway Dusp5 0.671259556 -0.575057373 0.005114 Down 7.561203845 7.893742277 6.146333938 5.013992486 4.178015931 5.264753433 dual specificity phosphatase 5 "GO:0000188,GO:0001706,GO:0004721,GO:0004722,GO:0004725,GO:0005634,GO:0005737,GO:0006470,GO:0008138,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0045892,GO:0045906,GO:0051019,GO:0106306,GO:0106307,GO:0120277" "inactivation of MAPK activity|endoderm formation|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|nucleus|cytoplasm|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|negative regulation of transcription, DNA-templated|negative regulation of vasoconstriction|mitogen-activated protein kinase binding|protein serine phosphatase activity|protein threonine phosphatase activity|positive regulation of cerebral blood circulation" mmu04010 MAPK signaling pathway Ebf3 1.57457142 0.654959197 0.019884132 Up 0.733798674 0.597828752 0.37400959 0.741742979 1.020246377 0.8585885 early B cell factor 3 "GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0045893,GO:0045944,GO:0046872,GO:0046983" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|protein dimerization activity" Eif2ak2 0.529256203 -0.917961822 9.89E-07 Down 2.169805366 2.825642028 3.468410114 1.469462272 1.404938725 1.532036014 eukaryotic translation initiation factor 2-alpha kinase 2 "GO:0000166,GO:0000186,GO:0001819,GO:0002376,GO:0003723,GO:0003725,GO:0004672,GO:0004674,GO:0004694,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0006468,GO:0009615,GO:0009636,GO:0016301,GO:0016310,GO:0016740,GO:0017148,GO:0030968,GO:0032496,GO:0032722,GO:0032874,GO:0033197,GO:0033689,GO:0034198,GO:0035455,GO:0042802,GO:0043065,GO:0043066,GO:0045071,GO:0045087,GO:0046777,GO:0048471,GO:0051092,GO:0051607,GO:0106310,GO:0106311,GO:1900225,GO:1901224,GO:1901532,GO:1902033,GO:1902036" nucleotide binding|activation of MAPKK activity|positive regulation of cytokine production|immune system process|RNA binding|double-stranded RNA binding|protein kinase activity|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|translation|protein phosphorylation|response to virus|response to toxic substance|kinase activity|phosphorylation|transferase activity|negative regulation of translation|endoplasmic reticulum unfolded protein response|response to lipopolysaccharide|positive regulation of chemokine production|positive regulation of stress-activated MAPK cascade|response to vitamin E|negative regulation of osteoblast proliferation|cellular response to amino acid starvation|response to interferon-alpha|identical protein binding|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of viral genome replication|innate immune response|protein autophosphorylation|perinuclear region of cytoplasm|positive regulation of NF-kappaB transcription factor activity|defense response to virus|protein serine kinase activity|protein threonine kinase activity|regulation of NLRP3 inflammasome complex assembly|positive regulation of NIK/NF-kappaB signaling|regulation of hematopoietic progenitor cell differentiation|regulation of hematopoietic stem cell proliferation|regulation of hematopoietic stem cell differentiation "mmu04141,mmu04217,mmu05010,mmu05160,mmu05162,mmu05164,mmu05165,mmu05167,mmu05168,mmu05169,mmu05171,mmu05203" Protein processing in endoplasmic reticulum|Necroptosis|Alzheimer disease|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Viral carcinogenesis Entpd4b 0.306185941 -1.707520055 0.031015586 Down 6.70735313 4.507525439 6.962451147 0.682026077 3.904013044 2.197936166 ectonucleoside triphosphate diphosphohydrolase 4B "GO:0000139,GO:0000421,GO:0004382,GO:0017110,GO:0017111,GO:0030173,GO:0036384,GO:0043273,GO:0045134,GO:0097637" Golgi membrane|autophagosome membrane|guanosine-diphosphatase activity|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|integral component of Golgi membrane|cytidine-diphosphatase activity|CTPase activity|uridine-diphosphatase activity|integral component of autophagosome membrane "mmu00230,mmu00240,mmu04142" Purine metabolism|Pyrimidine metabolism|Lysosome Eps8l1 1.585041551 0.66452066 0.01491194 Up 1.142021016 0.677694633 1.005892211 1.256952143 1.331714847 1.861593286 EPS8-like 1 "GO:0001726,GO:0003779,GO:0005085,GO:0005737,GO:0005829,GO:0005886,GO:0007266,GO:0016601,GO:0032587,GO:0032991,GO:0035023,GO:0042608,GO:0051015,GO:1900029" ruffle|actin binding|guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|plasma membrane|Rho protein signal transduction|Rac protein signal transduction|ruffle membrane|protein-containing complex|regulation of Rho protein signal transduction|T cell receptor binding|actin filament binding|positive regulation of ruffle assembly Epsti1 0.490219361 -1.028500631 0.049076815 Down 0.683647548 0.969260928 0.883810817 0.49839614 0.385541324 0.355910421 epithelial stromal interaction 1 (breast) Ermn 1.234176789 0.303549067 0.000435571 Up 17.79582919 22.63477381 18.27441022 22.87325209 24.72432029 24.39887881 "ermin, ERM-like protein" "GO:0001763,GO:0003779,GO:0005737,GO:0005856,GO:0005938,GO:0007015,GO:0008360,GO:0030175,GO:0031344,GO:0033269,GO:0033270,GO:0043025,GO:0043209,GO:0051015" morphogenesis of a branching structure|actin binding|cytoplasm|cytoskeleton|cell cortex|actin filament organization|regulation of cell shape|filopodium|regulation of cell projection organization|internode region of axon|paranode region of axon|neuronal cell body|myelin sheath|actin filament binding Fabp7 0.623341946 -0.681904296 6.94E-06 Down 42.74004019 40.34150728 24.16962954 27.06109094 20.59422824 18.16614432 "fatty acid binding protein 7, brain" "GO:0001964,GO:0005504,GO:0005634,GO:0005737,GO:0005829,GO:0005911,GO:0008289,GO:0021846,GO:0022008,GO:0042995,GO:0043025,GO:0044297,GO:0050673,GO:0060134,GO:0071944" startle response|fatty acid binding|nucleus|cytoplasm|cytosol|cell-cell junction|lipid binding|cell proliferation in forebrain|neurogenesis|cell projection|neuronal cell body|cell body|epithelial cell proliferation|prepulse inhibition|cell periphery mmu03320 PPAR signaling pathway Fam83d 0.498635629 -1.003942123 0.015221088 Down 0.618964469 0.65075698 1.039693767 0.452423883 0.318263747 0.360191771 "family with sequence similarity 83, member D" "GO:0001837,GO:0005737,GO:0005819,GO:0005829,GO:0005856,GO:0007049,GO:0007165,GO:0008017,GO:0008283,GO:0015630,GO:0016477,GO:0019894,GO:0019901,GO:0032006,GO:0042176,GO:0045171,GO:0051301,GO:0051310,GO:0070372,GO:0072686,GO:0097431,GO:1902480,GO:1902808" epithelial to mesenchymal transition|cytoplasm|spindle|cytosol|cytoskeleton|cell cycle|signal transduction|microtubule binding|cell population proliferation|microtubule cytoskeleton|cell migration|kinesin binding|protein kinase binding|regulation of TOR signaling|regulation of protein catabolic process|intercellular bridge|cell division|metaphase plate congression|regulation of ERK1 and ERK2 cascade|mitotic spindle|mitotic spindle pole|protein localization to mitotic spindle|positive regulation of cell cycle G1/S phase transition Fcgr1 0.554799996 -0.849960318 0.009104309 Down 2.709700544 1.802212262 2.865787493 1.280037533 1.789925069 1.037419079 "Fc receptor, IgG, high affinity I" "GO:0001788,GO:0001798,GO:0001805,GO:0002376,GO:0004888,GO:0005886,GO:0005887,GO:0006898,GO:0006910,GO:0006911,GO:0007166,GO:0009617,GO:0009897,GO:0016020,GO:0016021,GO:0019770,GO:0019864,GO:0019884,GO:0031774,GO:0042590,GO:0042742,GO:0045087,GO:0045121,GO:0050766,GO:0050776,GO:0060100,GO:0061098" "antibody-dependent cellular cytotoxicity|positive regulation of type IIa hypersensitivity|positive regulation of type III hypersensitivity|immune system process|transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|phagocytosis, recognition|phagocytosis, engulfment|cell surface receptor signaling pathway|response to bacterium|external side of plasma membrane|membrane|integral component of membrane|IgG receptor activity|IgG binding|antigen processing and presentation of exogenous antigen|leukotriene receptor binding|antigen processing and presentation of exogenous peptide antigen via MHC class I|defense response to bacterium|innate immune response|membrane raft|positive regulation of phagocytosis|regulation of immune response|positive regulation of phagocytosis, engulfment|positive regulation of protein tyrosine kinase activity" "mmu04145,mmu04380,mmu04613,mmu04640,mmu04666,mmu05140,mmu05150,mmu05152,mmu05202,mmu05221,mmu05322" Phagosome|Osteoclast differentiation|Neutrophil extracellular trap formation|Hematopoietic cell lineage|Fc gamma R-mediated phagocytosis|Leishmaniasis|Staphylococcus aureus infection|Tuberculosis|Transcriptional misregulation in cancer|Acute myeloid leukemia|Systemic lupus erythematosus Fdps 1.20201738 0.265457756 0.012726416 Up 29.02103538 37.04637888 35.26057553 41.08181604 41.34256624 38.67675625 farnesyl diphosphate synthetase "GO:0004161,GO:0004337,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005829,GO:0006629,GO:0006694,GO:0006695,GO:0008202,GO:0008203,GO:0008299,GO:0016126,GO:0016740,GO:0045337,GO:0045542,GO:0046872,GO:0061051" dimethylallyltranstransferase activity|geranyltranstransferase activity|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|peroxisome|cytosol|lipid metabolic process|steroid biosynthetic process|cholesterol biosynthetic process|steroid metabolic process|cholesterol metabolic process|isoprenoid biosynthetic process|sterol biosynthetic process|transferase activity|farnesyl diphosphate biosynthetic process|positive regulation of cholesterol biosynthetic process|metal ion binding|positive regulation of cell growth involved in cardiac muscle cell development "mmu00900,mmu05164,mmu05166" Terpenoid backbone biosynthesis|Influenza A|Human T-cell leukemia virus 1 infection Fgd2 0.693726809 -0.527560456 0.049785716 Down 2.147463695 2.358183233 1.991442799 1.434802514 1.526128461 1.532110634 "FYVE, RhoGEF and PH domain containing 2" "GO:0001726,GO:0005085,GO:0005634,GO:0005737,GO:0005768,GO:0005769,GO:0005856,GO:0005886,GO:0007010,GO:0016020,GO:0042995,GO:0043507,GO:0046847,GO:0046872,GO:1901981" ruffle|guanyl-nucleotide exchange factor activity|nucleus|cytoplasm|endosome|early endosome|cytoskeleton|plasma membrane|cytoskeleton organization|membrane|cell projection|positive regulation of JUN kinase activity|filopodium assembly|metal ion binding|phosphatidylinositol phosphate binding Fndc9 1.624830679 0.700289385 0.019124211 Up 1.583967505 3.274675568 1.13937962 3.231055748 3.234554516 2.510678298 fibronectin type III domain containing 9 "GO:0016020,GO:0016021" membrane|integral component of membrane Fosl2 0.830063454 -0.268706468 0.039825368 Down 5.336967392 6.093222214 4.235816932 4.353286266 4.194389317 4.310978172 fos-like antigen 2 "GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001666,GO:0003334,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006366,GO:0032355,GO:0043565,GO:0045893,GO:0045944,GO:0048146" "transcription cis-regulatory region binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|response to hypoxia|keratinocyte development|DNA binding|chromatin binding|double-stranded DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|response to estradiol|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of fibroblast proliferation" mmu04380 Osteoclast differentiation Foxd3 0.160917492 -2.635606933 0.037698654 Down 0.582638002 0.208191904 0.022174773 0.110837436 0 0.021766329 forkhead box D3 "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001701,GO:0001829,GO:0001892,GO:0003677,GO:0003690,GO:0003700,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0006357,GO:0007275,GO:0009653,GO:0030154,GO:0043565,GO:0045944,GO:1990830,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|transcription cis-regulatory region binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|in utero embryonic development|trophectodermal cell differentiation|embryonic placenta development|DNA binding|double-stranded DNA binding|DNA-binding transcription factor activity|nucleus|transcription regulator complex|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding" Frmd7 0.406700603 -1.297960964 0.044513841 Down 1.375962981 1.10625258 0.180208001 0.595876773 0.187280169 0.170085287 FERM domain containing 7 "GO:0005085,GO:0005515,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0007399,GO:0010592,GO:0010975,GO:0030426,GO:0032091,GO:0042995,GO:0043005,GO:0043025,GO:0051057,GO:0051497" guanyl-nucleotide exchange factor activity|protein binding|nucleoplasm|cytosol|cytoskeleton|plasma membrane|nervous system development|positive regulation of lamellipodium assembly|regulation of neuron projection development|growth cone|negative regulation of protein binding|cell projection|neuron projection|neuronal cell body|positive regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly Fzd4 0.796206638 -0.328785196 0.045654435 Down 2.540500496 2.12239759 2.625203031 1.953675699 1.890111692 1.932636498 frizzled class receptor 4 "GO:0001540,GO:0001553,GO:0001568,GO:0001570,GO:0004888,GO:0004896,GO:0004930,GO:0005515,GO:0005615,GO:0005886,GO:0005911,GO:0007165,GO:0007166,GO:0007186,GO:0007223,GO:0007275,GO:0007605,GO:0009986,GO:0010812,GO:0016020,GO:0016021,GO:0016055,GO:0017147,GO:0019955,GO:0030165,GO:0030425,GO:0030947,GO:0031625,GO:0031987,GO:0034446,GO:0035426,GO:0035567,GO:0038023,GO:0042701,GO:0042803,GO:0042813,GO:0043507,GO:0044877,GO:0045202,GO:0045893,GO:0046982,GO:0051091,GO:0060070,GO:0061299,GO:0061301,GO:0061304,GO:0090090,GO:0098978,GO:0110135,GO:0150012,GO:1990830" "amyloid-beta binding|luteinization|blood vessel development|vasculogenesis|transmembrane signaling receptor activity|cytokine receptor activity|G protein-coupled receptor activity|protein binding|extracellular space|plasma membrane|cell-cell junction|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|multicellular organism development|sensory perception of sound|cell surface|negative regulation of cell-substrate adhesion|membrane|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|cytokine binding|PDZ domain binding|dendrite|regulation of vascular endothelial growth factor receptor signaling pathway|ubiquitin protein ligase binding|locomotion involved in locomotory behavior|substrate adhesion-dependent cell spreading|extracellular matrix-cell signaling|non-canonical Wnt signaling pathway|signaling receptor activity|progesterone secretion|protein homodimerization activity|Wnt-activated receptor activity|positive regulation of JUN kinase activity|protein-containing complex binding|synapse|positive regulation of transcription, DNA-templated|protein heterodimerization activity|positive regulation of DNA-binding transcription factor activity|canonical Wnt signaling pathway|retina vasculature morphogenesis in camera-type eye|cerebellum vasculature morphogenesis|retinal blood vessel morphogenesis|negative regulation of canonical Wnt signaling pathway|glutamatergic synapse|Norrin signaling pathway|positive regulation of neuron projection arborization|cellular response to leukemia inhibitory factor" "mmu04150,mmu04310,mmu04390,mmu04550,mmu04916,mmu04934,mmu05010,mmu05022,mmu05165,mmu05200,mmu05205,mmu05217,mmu05224,mmu05225,mmu05226" mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer Galnt15 0.581979869 -0.780958843 0.046938512 Down 0.849347034 0.646148655 1.1965657 0.49254164 0.507162849 0.525082128 polypeptide N-acetylgalactosaminyltransferase 15 "GO:0004653,GO:0005794,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030133,GO:0030246,GO:0046872" polypeptide N-acetylgalactosaminyltransferase activity|Golgi apparatus|membrane|integral component of membrane|transferase activity|glycosyltransferase activity|transport vesicle|carbohydrate binding|metal ion binding "mmu00512,mmu00514" Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis Gbp2 0.370950728 -1.430700524 3.29E-08 Down 3.233054187 4.047120575 3.558062007 1.264196898 1.437167989 1.304437064 guanylate binding protein 2 "GO:0000166,GO:0003924,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0009617,GO:0016020,GO:0016787,GO:0020005,GO:0031410,GO:0034504,GO:0035458,GO:0042802,GO:0042803,GO:0042832,GO:0044406,GO:0048471,GO:0050830,GO:0071222,GO:0071346" nucleotide binding|GTPase activity|GTP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|response to bacterium|membrane|hydrolase activity|symbiont-containing vacuole membrane|cytoplasmic vesicle|protein localization to nucleus|cellular response to interferon-beta|identical protein binding|protein homodimerization activity|defense response to protozoan|adhesion of symbiont to host|perinuclear region of cytoplasm|defense response to Gram-positive bacterium|cellular response to lipopolysaccharide|cellular response to interferon-gamma mmu04621 NOD-like receptor signaling pathway Gbp3 0.242352274 -2.044822478 1.03E-18 Down 4.510159504 4.503167707 4.032304436 0.986837324 1.004650095 1.166059298 guanylate binding protein 3 "GO:0000166,GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0016020,GO:0016787,GO:0020005,GO:0031410,GO:0035458,GO:0042802,GO:0042803,GO:0042832,GO:0044406,GO:0048471,GO:0050830,GO:0071346" nucleotide binding|GTPase activity|GTP binding|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|membrane|hydrolase activity|symbiont-containing vacuole membrane|cytoplasmic vesicle|cellular response to interferon-beta|identical protein binding|protein homodimerization activity|defense response to protozoan|adhesion of symbiont to host|perinuclear region of cytoplasm|defense response to Gram-positive bacterium|cellular response to interferon-gamma mmu04621 NOD-like receptor signaling pathway Gbp4 0.355575176 -1.491773488 1.45E-05 Down 1.122215624 1.333044744 0.914239841 0.342727297 0.353495343 0.499688745 guanylate binding protein 4 "GO:0000122,GO:0001933,GO:0003924,GO:0005515,GO:0005525,GO:0031397,GO:0031410,GO:0032687,GO:0042308,GO:0042832,GO:0050688,GO:0050830,GO:0071346" negative regulation of transcription by RNA polymerase II|negative regulation of protein phosphorylation|GTPase activity|protein binding|GTP binding|negative regulation of protein ubiquitination|cytoplasmic vesicle|negative regulation of interferon-alpha production|negative regulation of protein import into nucleus|defense response to protozoan|regulation of defense response to virus|defense response to Gram-positive bacterium|cellular response to interferon-gamma Gbp5 0.42419839 -1.237188949 1.19E-05 Down 2.1866122 3.234359886 2.212126286 1.149231219 1.028455524 1.00875157 guanylate binding protein 5 "GO:0000166,GO:0002376,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0006954,GO:0009617,GO:0016020,GO:0016787,GO:0031410,GO:0032731,GO:0032741,GO:0034067,GO:0042802,GO:0042803,GO:0045089,GO:0048471,GO:0051289,GO:0071346,GO:1900017,GO:1900227" nucleotide binding|immune system process|GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|inflammatory response|response to bacterium|membrane|hydrolase activity|cytoplasmic vesicle|positive regulation of interleukin-1 beta production|positive regulation of interleukin-18 production|protein localization to Golgi apparatus|identical protein binding|protein homodimerization activity|positive regulation of innate immune response|perinuclear region of cytoplasm|protein homotetramerization|cellular response to interferon-gamma|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly mmu04621 NOD-like receptor signaling pathway Gbp6 0.366539437 -1.447959666 0.000343266 Down 0.803728378 0.861579954 0.780655946 0.384544658 0.215125301 0.310952913 guanylate binding protein 6 "GO:0003924,GO:0005525,GO:0009617,GO:0020005,GO:0031410,GO:0035458,GO:0042832,GO:0044406,GO:0050830,GO:0071222,GO:0071346" GTPase activity|GTP binding|response to bacterium|symbiont-containing vacuole membrane|cytoplasmic vesicle|cellular response to interferon-beta|defense response to protozoan|adhesion of symbiont to host|defense response to Gram-positive bacterium|cellular response to lipopolysaccharide|cellular response to interferon-gamma Gbp7 0.464165781 -1.107287926 6.97E-06 Down 1.46645188 1.796577874 2.3961061 0.954384847 0.711880308 0.92792627 guanylate binding protein 7 "GO:0003924,GO:0005525,GO:0020005,GO:0031410,GO:0042832,GO:0044406,GO:0050830,GO:0071346" GTPase activity|GTP binding|symbiont-containing vacuole membrane|cytoplasmic vesicle|defense response to protozoan|adhesion of symbiont to host|defense response to Gram-positive bacterium|cellular response to interferon-gamma mmu04621 NOD-like receptor signaling pathway Gbp9 0.535795211 -0.90024641 0.00012928 Down 1.564213386 1.657192181 1.908183185 0.958476529 0.799595351 0.987265182 guanylate-binding protein 9 "GO:0003924,GO:0005525,GO:0020005,GO:0031410,GO:0042832,GO:0044406,GO:0050830,GO:0071346" GTPase activity|GTP binding|symbiont-containing vacuole membrane|cytoplasmic vesicle|defense response to protozoan|adhesion of symbiont to host|defense response to Gram-positive bacterium|cellular response to interferon-gamma Gck 2.010241498 1.007368829 0.024467724 Up 0.336217629 0.47011075 0.300432408 0.690767505 0.826812019 0.678266913 glucokinase "GO:0000166,GO:0000287,GO:0001678,GO:0003824,GO:0004340,GO:0004396,GO:0005515,GO:0005524,GO:0005536,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005884,GO:0005938,GO:0005975,GO:0005978,GO:0006002,GO:0006003,GO:0006006,GO:0006013,GO:0006096,GO:0006739,GO:0007204,GO:0008152,GO:0008865,GO:0016301,GO:0016310,GO:0016740,GO:0016773,GO:0019158,GO:0019903,GO:0019932,GO:0030141,GO:0032024,GO:0032811,GO:0032869,GO:0042149,GO:0042327,GO:0042593,GO:0043266,GO:0043531,GO:0044320,GO:0045180,GO:0045721,GO:0045725,GO:0045821,GO:0046835,GO:0050796,GO:0051156,GO:0051594,GO:0055088,GO:0070509" "nucleotide binding|magnesium ion binding|cellular glucose homeostasis|catalytic activity|glucokinase activity|hexokinase activity|protein binding|ATP binding|glucose binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|actin filament|cell cortex|carbohydrate metabolic process|glycogen biosynthetic process|fructose 6-phosphate metabolic process|fructose 2,6-bisphosphate metabolic process|glucose metabolic process|mannose metabolic process|glycolytic process|NADP metabolic process|positive regulation of cytosolic calcium ion concentration|metabolic process|fructokinase activity|kinase activity|phosphorylation|transferase activity|phosphotransferase activity, alcohol group as acceptor|mannokinase activity|protein phosphatase binding|second-messenger-mediated signaling|secretory granule|positive regulation of insulin secretion|negative regulation of epinephrine secretion|cellular response to insulin stimulus|cellular response to glucose starvation|positive regulation of phosphorylation|glucose homeostasis|regulation of potassium ion transport|ADP binding|cellular response to leptin stimulus|basal cortex|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of glycolytic process|carbohydrate phosphorylation|regulation of insulin secretion|glucose 6-phosphate metabolic process|detection of glucose|lipid homeostasis|calcium ion import" "mmu00010,mmu00052,mmu00500,mmu00520,mmu00524,mmu04910,mmu04911,mmu04917,mmu04922,mmu04930,mmu04950,mmu05230" "Glycolysis / Gluconeogenesis|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|Insulin signaling pathway|Insulin secretion|Prolactin signaling pathway|Glucagon signaling pathway|Type II diabetes mellitus|Maturity onset diabetes of the young|Central carbon metabolism in cancer" Glra1 2.036547963 1.026125792 0.017306279 Up 0.742751443 0.773464989 0.348914953 1.351601212 1.222123047 1.070275588 "glycine receptor, alpha 1 subunit" "GO:0001508,GO:0001964,GO:0002087,GO:0004888,GO:0005216,GO:0005230,GO:0005254,GO:0005622,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006821,GO:0006936,GO:0007165,GO:0007218,GO:0007268,GO:0007340,GO:0007601,GO:0007628,GO:0008270,GO:0009897,GO:0016020,GO:0016021,GO:0016594,GO:0016933,GO:0016934,GO:0022824,GO:0030054,GO:0030594,GO:0030977,GO:0034220,GO:0034707,GO:0042391,GO:0042802,GO:0042995,GO:0043005,GO:0043025,GO:0043200,GO:0043231,GO:0043576,GO:0044305,GO:0044877,GO:0045202,GO:0045211,GO:0046872,GO:0050877,GO:0050884,GO:0050905,GO:0051970,GO:0060012,GO:0060013,GO:0060077,GO:0060080,GO:0071230,GO:0071294,GO:0071361,GO:0097305,GO:0098690,GO:0099056,GO:0099060,GO:1902476,GO:1904315,GO:2000344" "action potential|startle response|regulation of respiratory gaseous exchange by nervous system process|transmembrane signaling receptor activity|ion channel activity|extracellular ligand-gated ion channel activity|chloride channel activity|intracellular anatomical structure|plasma membrane|integral component of plasma membrane|ion transport|anion transport|chloride transport|muscle contraction|signal transduction|neuropeptide signaling pathway|chemical synaptic transmission|acrosome reaction|visual perception|adult walking behavior|zinc ion binding|external side of plasma membrane|membrane|integral component of membrane|glycine binding|extracellularly glycine-gated ion channel activity|extracellularly glycine-gated chloride channel activity|transmitter-gated ion channel activity|cell junction|neurotransmitter receptor activity|taurine binding|ion transmembrane transport|chloride channel complex|regulation of membrane potential|identical protein binding|cell projection|neuron projection|neuronal cell body|response to amino acid|intracellular membrane-bounded organelle|regulation of respiratory gaseous exchange|calyx of Held|protein-containing complex binding|synapse|postsynaptic membrane|metal ion binding|nervous system process|neuromuscular process controlling posture|neuromuscular process|negative regulation of transmission of nerve impulse|synaptic transmission, glycinergic|righting reflex|inhibitory synapse|inhibitory postsynaptic potential|cellular response to amino acid stimulus|cellular response to zinc ion|cellular response to ethanol|response to alcohol|glycinergic synapse|integral component of presynaptic membrane|integral component of postsynaptic specialization membrane|chloride transmembrane transport|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|positive regulation of acrosome reaction" mmu04080 Neuroactive ligand-receptor interaction Gm12185 0.100753457 -3.311098755 0.022510575 Down 0.067798723 0.093444181 0.099528535 0.019899167 0.009960357 0 predicted gene 12185 "GO:0003924,GO:0005789,GO:0006952,GO:0035458" GTPase activity|endoplasmic reticulum membrane|defense response|cellular response to interferon-beta Gm12250 0.181109126 -2.465068851 0.000617281 Down 0.530646701 0.345368434 0.856888378 0.175215035 0.038978837 0.114696151 predicted gene 12250 Gm2115 1.223412394 0.290910797 0.028786332 Up 5.420944355 4.792452935 5.049016242 5.768408379 6.052282366 6.851284992 predicted gene 2115 "GO:0016020,GO:0016021" membrane|integral component of membrane Gm4951 0.280276231 -1.835078692 0.003877151 Down 0.296159609 0.408184567 0.666635602 0.130385851 0.087018027 0.15647659 predicted gene 4951 "GO:0003924,GO:0005789,GO:0006952,GO:0035458" GTPase activity|endoplasmic reticulum membrane|defense response|cellular response to interferon-beta Gm5431 0.243825804 -2.036077281 0.038072839 Down 0.120650234 0.221716319 0.460497861 0.088528184 0.053174429 0.034770448 predicted gene 5431 "GO:0003924,GO:0005789,GO:0006952,GO:0035458" GTPase activity|endoplasmic reticulum membrane|defense response|cellular response to interferon-beta mmu04668 TNF signaling pathway Gm5741 30.84582124 4.947003152 0.001670109 Up 0 0.167357516 0 1.92451636 2.408250418 1.102318595 predicted gene 5741 "GO:0005834,GO:0007186,GO:0031680,GO:0031681" heterotrimeric G-protein complex|G protein-coupled receptor signaling pathway|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding "mmu04010,mmu04014,mmu04062,mmu04151,mmu04371,mmu04713,mmu04723,mmu04724,mmu04725,mmu04726,mmu04727,mmu04728,mmu04810,mmu04926,mmu05032,mmu05034,mmu05163,mmu05167,mmu05170,mmu05200" MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Regulation of actin cytoskeleton|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer Gng4 0.770910121 -0.375365427 0.000160409 Down 36.2502417 29.31357809 18.00992883 25.22504485 20.58440123 16.96280406 "guanine nucleotide binding protein (G protein), gamma 4" "GO:0003924,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0016020,GO:0030308,GO:0031680,GO:0031681" GTPase activity|heterotrimeric G-protein complex|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|membrane|negative regulation of cell growth|G-protein beta/gamma-subunit complex|G-protein beta-subunit binding "mmu04014,mmu04062,mmu04151,mmu04371,mmu04713,mmu04723,mmu04724,mmu04725,mmu04726,mmu04727,mmu04728,mmu04926,mmu05032,mmu05034,mmu05163,mmu05167,mmu05170,mmu05200" Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer Gpr151 2.8890743 1.530607307 0.000227779 Up 0.780248295 1.115213064 0.534522152 1.692097341 2.31800898 2.973167601 G protein-coupled receptor 151 "GO:0004930,GO:0005886,GO:0005887,GO:0007165,GO:0007186,GO:0010447,GO:0016020,GO:0016021,GO:0042802" G protein-coupled receptor activity|plasma membrane|integral component of plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|response to acidic pH|membrane|integral component of membrane|identical protein binding Gpsm1 0.791853995 -0.336693649 0.001166277 Down 12.49339929 11.09889104 8.937102308 8.951892443 8.242884598 8.328641179 "G-protein signalling modulator 1 (AGS3-like, C. elegans)" "GO:0000139,GO:0001965,GO:0005092,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005938,GO:0007275,GO:0007399,GO:0008277,GO:0016020,GO:0016239,GO:0030154,GO:0030695,GO:0032991,GO:0034260,GO:1905098" Golgi membrane|G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cell cortex|multicellular organism development|nervous system development|regulation of G protein-coupled receptor signaling pathway|membrane|positive regulation of macroautophagy|cell differentiation|GTPase regulator activity|protein-containing complex|negative regulation of GTPase activity|negative regulation of guanyl-nucleotide exchange factor activity mmu05030 Cocaine addiction Gpt2 0.803007805 -0.316514084 0.004311717 Down 9.001560495 10.01212794 12.65829862 8.536822535 8.455311994 8.167212607 glutamic pyruvate transaminase (alanine aminotransferase) 2 "GO:0003824,GO:0004021,GO:0005615,GO:0005739,GO:0006103,GO:0008483,GO:0009058,GO:0016740,GO:0030170,GO:0042851,GO:0045722" catalytic activity|L-alanine:2-oxoglutarate aminotransferase activity|extracellular space|mitochondrion|2-oxoglutarate metabolic process|transaminase activity|biosynthetic process|transferase activity|pyridoxal phosphate binding|L-alanine metabolic process|positive regulation of gluconeogenesis "mmu00220,mmu00250" "Arginine biosynthesis|Alanine, aspartate and glutamate metabolism" Gpx3 1.278378955 0.354315563 0.048813616 Up 8.29192864 12.92604083 10.37454566 15.02026736 15.65491767 9.83230035 glutathione peroxidase 3 "GO:0004601,GO:0004602,GO:0005576,GO:0005615,GO:0006749,GO:0006979,GO:0008430,GO:0016491,GO:0042744,GO:0042802" peroxidase activity|glutathione peroxidase activity|extracellular region|extracellular space|glutathione metabolic process|response to oxidative stress|selenium binding|oxidoreductase activity|hydrogen peroxide catabolic process|identical protein binding "mmu00480,mmu00590,mmu04918,mmu05014,mmu05016,mmu05022" Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases Grm2 0.829645662 -0.269432796 0.006645297 Down 20.57234061 16.30443961 17.10213518 15.49767523 14.46853853 14.57992985 "glutamate receptor, metabotropic 2" "GO:0001640,GO:0001641,GO:0004930,GO:0005246,GO:0005886,GO:0005887,GO:0007165,GO:0007186,GO:0007216,GO:0007268,GO:0010467,GO:0014047,GO:0014048,GO:0014059,GO:0016020,GO:0016021,GO:0030054,GO:0030424,GO:0033554,GO:0035095,GO:0042220,GO:0042734,GO:0042995,GO:0043005,GO:0045202,GO:0051896,GO:0051966,GO:0090461,GO:0097110,GO:0097449,GO:0099055,GO:2001023" "adenylate cyclase inhibiting G protein-coupled glutamate receptor activity|group II metabotropic glutamate receptor activity|G protein-coupled receptor activity|calcium channel regulator activity|plasma membrane|integral component of plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|G protein-coupled glutamate receptor signaling pathway|chemical synaptic transmission|gene expression|glutamate secretion|regulation of glutamate secretion|regulation of dopamine secretion|membrane|integral component of membrane|cell junction|axon|cellular response to stress|behavioral response to nicotine|response to cocaine|presynaptic membrane|cell projection|neuron projection|synapse|regulation of protein kinase B signaling|regulation of synaptic transmission, glutamatergic|glutamate homeostasis|scaffold protein binding|astrocyte projection|integral component of postsynaptic membrane|regulation of response to drug" "mmu04072,mmu04080,mmu04724,mmu05030" Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse|Cocaine addiction Gstm4 0.748127321 -0.418644278 0.04097883 Down 5.13219646 4.838466781 4.543983046 3.577505132 3.746310985 3.512764198 "glutathione S-transferase, mu 4" "GO:0004364,GO:0004464,GO:0005737,GO:0005829,GO:0006629,GO:0006749,GO:0016740,GO:0016829,GO:0018916,GO:0019899,GO:0042178,GO:0042759,GO:0042803,GO:0043295,GO:0045171" glutathione transferase activity|leukotriene-C4 synthase activity|cytoplasm|cytosol|lipid metabolic process|glutathione metabolic process|transferase activity|lyase activity|nitrobenzene metabolic process|enzyme binding|xenobiotic catabolic process|long-chain fatty acid biosynthetic process|protein homodimerization activity|glutathione binding|intercellular bridge "mmu00480,mmu00980,mmu00982,mmu00983,mmu01524,mmu05200,mmu05204,mmu05225,mmu05418" Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis Gvin1 0.240625207 -2.055140315 0.003427785 Down 0.130284331 0.170023388 0.157163704 0.040732758 0.029126332 0.03999563 "GTPase, very large interferon inducible 1" Gvin2 0.347880145 -1.523337756 0.022667566 Down 0.147326831 0.121485593 0.163038687 0.052388074 0.040790402 0.057155582 "GTPase, very large interferon inducible, family member 2" H2-Q4 0.541632757 -0.884613101 0.001519612 Down 6.454475126 4.469836435 2.934787301 2.317720205 2.584559958 2.275777184 "histocompatibility 2, Q region locus 4" "GO:0001916,GO:0002476,GO:0002486,GO:0005102,GO:0005615,GO:0005783,GO:0005794,GO:0005797,GO:0005886,GO:0006955,GO:0009897,GO:0009986,GO:0030881,GO:0042277,GO:0042605,GO:0042608,GO:0042610,GO:0042612,GO:0042824,GO:0044877,GO:0046977,GO:0062061,GO:0070971" "positive regulation of T cell mediated cytotoxicity|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|signaling receptor binding|extracellular space|endoplasmic reticulum|Golgi apparatus|Golgi medial cisterna|plasma membrane|immune response|external side of plasma membrane|cell surface|beta-2-microglobulin binding|peptide binding|peptide antigen binding|T cell receptor binding|CD8 receptor binding|MHC class I protein complex|MHC class I peptide loading complex|protein-containing complex binding|TAP binding|TAP complex binding|endoplasmic reticulum exit site" "mmu04144,mmu04145,mmu04218,mmu04514,mmu04612,mmu04650,mmu04940,mmu05163,mmu05165,mmu05166,mmu05167,mmu05168,mmu05169,mmu05170,mmu05203,mmu05320,mmu05330,mmu05332,mmu05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis H2-T23 0.589407453 -0.76266279 1.44E-06 Down 20.14080231 18.00599134 18.21948045 9.625991473 12.31541839 11.33430787 "histocompatibility 2, T region locus 23" "GO:0001815,GO:0001916,GO:0002250,GO:0002376,GO:0002474,GO:0002476,GO:0002477,GO:0002486,GO:0002489,GO:0002519,GO:0002639,GO:0002715,GO:0002717,GO:0002729,GO:0005102,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0019731,GO:0030670,GO:0030881,GO:0032398,GO:0032736,GO:0032753,GO:0032759,GO:0032760,GO:0032819,GO:0036037,GO:0042270,GO:0042288,GO:0042605,GO:0042608,GO:0042612,GO:0045953,GO:0045954,GO:0046703,GO:0048839,GO:0050830,GO:0071556,GO:2000566,GO:2001187" "positive regulation of antibody-dependent cellular cytotoxicity|positive regulation of T cell mediated cytotoxicity|adaptive immune response|immune system process|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class Ib|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|natural killer cell tolerance induction|positive regulation of immunoglobulin production|regulation of natural killer cell mediated immunity|positive regulation of natural killer cell mediated immunity|positive regulation of natural killer cell cytokine production|signaling receptor binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|cell surface|membrane|integral component of membrane|antibacterial humoral response|phagocytic vesicle membrane|beta-2-microglobulin binding|MHC class Ib protein complex|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of TRAIL production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell proliferation|CD8-positive, alpha-beta T cell activation|protection from natural killer cell mediated cytotoxicity|MHC class I protein binding|peptide antigen binding|T cell receptor binding|MHC class I protein complex|negative regulation of natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding|inner ear development|defense response to Gram-positive bacterium|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of CD8-positive, alpha-beta T cell proliferation|positive regulation of CD8-positive, alpha-beta T cell activation" "mmu04144,mmu04145,mmu04218,mmu04514,mmu04612,mmu04650,mmu04940,mmu05163,mmu05165,mmu05166,mmu05167,mmu05168,mmu05169,mmu05170,mmu05203,mmu05320,mmu05330,mmu05332,mmu05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis H2-T24 0.342514878 -1.545761438 0.000532936 Down 1.971320879 0.729562187 2.459814438 0.554481799 0.506814203 0.544447524 "histocompatibility 2, T region locus 24" "GO:0001916,GO:0002476,GO:0002486,GO:0005102,GO:0005615,GO:0006955,GO:0009897,GO:0042605" "positive regulation of T cell mediated cytotoxicity|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|signaling receptor binding|extracellular space|immune response|external side of plasma membrane|peptide antigen binding" "mmu04144,mmu04145,mmu04218,mmu04514,mmu04612,mmu04650,mmu04940,mmu05163,mmu05165,mmu05166,mmu05167,mmu05168,mmu05169,mmu05170,mmu05203,mmu05320,mmu05330,mmu05332,mmu05416" Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis Hba-a1 1.556437097 0.638247272 7.68E-06 Up 43.87897635 28.08492641 65.04638424 83.84556607 46.25449175 78.35504814 "hemoglobin alpha, adult chain 1" "GO:0001701,GO:0004601,GO:0005344,GO:0005615,GO:0005833,GO:0009617,GO:0019825,GO:0020037,GO:0022627,GO:0031720,GO:0031838,GO:0035634,GO:0042744,GO:0043177,GO:0043209,GO:0044877,GO:0048821" in utero embryonic development|peroxidase activity|oxygen carrier activity|extracellular space|hemoglobin complex|response to bacterium|oxygen binding|heme binding|cytosolic small ribosomal subunit|haptoglobin binding|haptoglobin-hemoglobin complex|response to stilbenoid|hydrogen peroxide catabolic process|organic acid binding|myelin sheath|protein-containing complex binding|erythrocyte development "mmu05143,mmu05144" African trypanosomiasis|Malaria Hba-a2 1.405263759 0.490840941 0.014785288 Up 14.8255902 10.33514408 19.90802279 18.68683736 14.12383975 31.65145198 "hemoglobin alpha, adult chain 2" "GO:0001701,GO:0004601,GO:0005615,GO:0005833,GO:0009617,GO:0019825,GO:0020037,GO:0022627,GO:0031720,GO:0031838,GO:0043177,GO:0044877,GO:0048821" in utero embryonic development|peroxidase activity|extracellular space|hemoglobin complex|response to bacterium|oxygen binding|heme binding|cytosolic small ribosomal subunit|haptoglobin binding|haptoglobin-hemoglobin complex|organic acid binding|protein-containing complex binding|erythrocyte development "mmu05143,mmu05144" African trypanosomiasis|Malaria Hbb-bs 1.395850834 0.481144778 4.58E-06 Up 67.71558468 41.06256775 84.07789009 88.66027013 64.03307965 112.6794849 "hemoglobin, beta adult s chain" "GO:0004601,GO:0005615,GO:0005833,GO:0019825,GO:0030492,GO:0031720,GO:0031721,GO:0031722,GO:0031838,GO:0044877" peroxidase activity|extracellular space|hemoglobin complex|oxygen binding|hemoglobin binding|haptoglobin binding|hemoglobin alpha binding|hemoglobin beta binding|haptoglobin-hemoglobin complex|protein-containing complex binding "mmu05143,mmu05144" African trypanosomiasis|Malaria Hbb-bt 1.454250887 0.540276184 0.017769275 Up 16.25631957 6.622044698 21.29886946 17.36748732 15.38018299 27.79342613 "hemoglobin, beta adult t chain" "GO:0004601,GO:0005344,GO:0005615,GO:0005833,GO:0019825,GO:0020037,GO:0030492,GO:0031720,GO:0031721,GO:0031722,GO:0031838,GO:0042744,GO:0043177,GO:0044877" peroxidase activity|oxygen carrier activity|extracellular space|hemoglobin complex|oxygen binding|heme binding|hemoglobin binding|haptoglobin binding|hemoglobin alpha binding|hemoglobin beta binding|haptoglobin-hemoglobin complex|hydrogen peroxide catabolic process|organic acid binding|protein-containing complex binding "mmu05143,mmu05144" African trypanosomiasis|Malaria Hck 0.565425321 -0.822591602 0.031360034 Down 1.860307316 1.521897412 1.609812201 0.854931742 1.107580307 0.864150333 hemopoietic cell kinase "GO:0000166,GO:0001784,GO:0002376,GO:0004672,GO:0004713,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005764,GO:0005794,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005901,GO:0005925,GO:0006468,GO:0006887,GO:0006909,GO:0006954,GO:0007169,GO:0008284,GO:0008360,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0018108,GO:0030054,GO:0030154,GO:0031234,GO:0031410,GO:0042995,GO:0043066,GO:0043231,GO:0045087,GO:0046777,GO:0050764,GO:0050830,GO:0051090,GO:0071801,GO:2000251" nucleotide binding|phosphotyrosine residue binding|immune system process|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signaling receptor binding|protein binding|ATP binding|nucleus|cytoplasm|lysosome|Golgi apparatus|cytosol|cytoskeleton|actin filament|plasma membrane|caveola|focal adhesion|protein phosphorylation|exocytosis|phagocytosis|inflammatory response|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of cell population proliferation|regulation of cell shape|membrane|kinase activity|phosphorylation|transferase activity|peptidyl-tyrosine phosphorylation|cell junction|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|cell projection|negative regulation of apoptotic process|intracellular membrane-bounded organelle|innate immune response|protein autophosphorylation|regulation of phagocytosis|defense response to Gram-positive bacterium|regulation of DNA-binding transcription factor activity|regulation of podosome assembly|positive regulation of actin cytoskeleton reorganization "mmu04062,mmu04666,mmu05167" Chemokine signaling pathway|Fc gamma R-mediated phagocytosis|Kaposi sarcoma-associated herpesvirus infection Helz2 0.448454631 -1.156966058 1.84E-05 Down 0.736224615 0.575915353 1.191046392 0.352597421 0.327401028 0.40141053 "helicase with zinc finger 2, transcriptional coactivator" "GO:0000166,GO:0000184,GO:0003677,GO:0003723,GO:0003724,GO:0004386,GO:0004540,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0016787,GO:0030374,GO:0045944,GO:0046872" "nucleotide binding|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|DNA binding|RNA binding|RNA helicase activity|helicase activity|ribonuclease activity|ATP binding|nucleus|nucleoplasm|cytoplasm|hydrolase activity|nuclear receptor coactivator activity|positive regulation of transcription by RNA polymerase II|metal ion binding" Hif3a 0.395132689 -1.339590892 0.000115569 Down 0.612179294 0.551841004 1.758551981 0.278703225 0.372006694 0.364879499 "hypoxia inducible factor 3, alpha subunit" "GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001525,GO:0001666,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006366,GO:0006915,GO:0007275,GO:0016607,GO:0045944,GO:0046983,GO:0071456" "chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|angiogenesis|response to hypoxia|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|apoptotic process|multicellular organism development|nuclear speck|positive regulation of transcription by RNA polymerase II|protein dimerization activity|cellular response to hypoxia" Hmgcs2 0.724672242 -0.464599462 0.017375376 Down 3.420045374 3.732875355 4.536821224 2.858535836 2.66979002 2.885208251 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 "GO:0004421,GO:0005739,GO:0005743,GO:0005759,GO:0006084,GO:0006629,GO:0006694,GO:0006695,GO:0008202,GO:0008203,GO:0008299,GO:0010142,GO:0016126,GO:0016740,GO:0016746,GO:0042802,GO:0046951" "hydroxymethylglutaryl-CoA synthase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|acetyl-CoA metabolic process|lipid metabolic process|steroid biosynthetic process|cholesterol biosynthetic process|steroid metabolic process|cholesterol metabolic process|isoprenoid biosynthetic process|farnesyl diphosphate biosynthetic process, mevalonate pathway|sterol biosynthetic process|transferase activity|acyltransferase activity|identical protein binding|ketone body biosynthetic process" "mmu00072,mmu00280,mmu00650,mmu00900,mmu03320" "Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism|Terpenoid backbone biosynthesis|PPAR signaling pathway" Hsf4 1.272623276 0.347805414 0.049649732 Up 6.543315799 6.275950141 5.716686303 7.184330085 8.744951543 7.668898329 heat shock transcription factor 4 "GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0001654,GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0007601,GO:0008284,GO:0016607,GO:0019903,GO:0033169,GO:0042802,GO:0043010,GO:0043565,GO:0045597,GO:0045944,GO:0048468,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|eye development|DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|visual perception|positive regulation of cell population proliferation|nuclear speck|protein phosphatase binding|histone H3-K9 demethylation|identical protein binding|camera-type eye development|sequence-specific DNA binding|positive regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|cell development|sequence-specific double-stranded DNA binding" Ifi204 0.134230339 -2.897217305 2.39E-05 Down 0.646783446 0.502072548 1.420943228 0.114554545 0.091742873 0.112481489 interferon activated gene 204 "GO:0000978,GO:0001227,GO:0002218,GO:0003690,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006357,GO:0007275,GO:0008134,GO:0009617,GO:0016607,GO:0032731,GO:0035457,GO:0035458,GO:0042405,GO:0042771,GO:0042802,GO:0045669,GO:0048839" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|activation of innate immune response|double-stranded DNA binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|multicellular organism development|transcription factor binding|response to bacterium|nuclear speck|positive regulation of interleukin-1 beta production|cellular response to interferon-alpha|cellular response to interferon-beta|nuclear inclusion body|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|positive regulation of osteoblast differentiation|inner ear development" mmu04621 NOD-like receptor signaling pathway Ifi206 0.031689206 -4.979864667 0.001099369 Down 0.143760266 0.092464793 0.295456127 0 0 0.014500702 interferon activated gene 206 "GO:0000978,GO:0001227,GO:0003690,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0008134,GO:0035458,GO:0042802" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|double-stranded DNA binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription factor binding|cellular response to interferon-beta|identical protein binding" mmu04621 NOD-like receptor signaling pathway Ifi209 0.101716823 -3.297369785 0.000228031 Down 0.175718868 0.361036632 0.601895754 0.04512735 0.030117477 0.029540463 interferon activated gene 209 "GO:0000978,GO:0001227,GO:0002218,GO:0003690,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0008134,GO:0035458,GO:0042802" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|activation of innate immune response|double-stranded DNA binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription factor binding|cellular response to interferon-beta|identical protein binding" Ifi213 0.185497497 -2.430528371 0.036182508 Down 0.042954086 0.052623861 0.119807548 0.006303589 0.031552073 0.006189515 interferon activated gene 213 "GO:0000978,GO:0001227,GO:0003690,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0008134,GO:0035458,GO:0042802" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|double-stranded DNA binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription factor binding|cellular response to interferon-beta|identical protein binding" Ifi27 0.495572826 -1.012831014 0.001005841 Down 63.17039053 53.32935457 33.73124122 22.58001721 24.05475479 25.45786177 "interferon, alpha-inducible protein 27" "GO:0000122,GO:0005521,GO:0005637,GO:0005739,GO:0046825,GO:0061629,GO:0097190" negative regulation of transcription by RNA polymerase II|lamin binding|nuclear inner membrane|mitochondrion|regulation of protein export from nucleus|RNA polymerase II-specific DNA-binding transcription factor binding|apoptotic signaling pathway Ifi27l2a 0.13662727 -2.871682632 8.65E-05 Down 11.71449167 8.081681182 3.33721544 0.536161976 1.312037374 1.052918458 "interferon, alpha-inducible protein 27 like 2A" "GO:0005634,GO:0005739,GO:0007568,GO:0009615,GO:0016020,GO:0016021,GO:0097190" nucleus|mitochondrion|aging|response to virus|membrane|integral component of membrane|apoptotic signaling pathway Ifi35 0.409283064 -1.288829127 0.000193006 Down 3.16281041 3.551917164 4.333472402 1.740555237 1.355231117 1.405224629 interferon-induced protein 35 "GO:0002281,GO:0002376,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0008285,GO:0016020,GO:0034145,GO:0042802,GO:0045087,GO:0045089,GO:0050729,GO:1901223,GO:1901224" macrophage activation involved in immune response|immune system process|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|negative regulation of cell population proliferation|membrane|positive regulation of toll-like receptor 4 signaling pathway|identical protein binding|innate immune response|positive regulation of innate immune response|positive regulation of inflammatory response|negative regulation of NIK/NF-kappaB signaling|positive regulation of NIK/NF-kappaB signaling Ifi44 0.148632735 -2.750176208 1.74E-10 Down 1.342851573 1.151606964 3.017412851 0.183928137 0.294603687 0.28895944 interferon-induced protein 44 "GO:0005737,GO:0006955,GO:0009617" cytoplasm|immune response|response to bacterium Ifi47 0.274637907 -1.864397328 5.81E-07 Down 2.264013508 1.854317952 3.215275989 0.601032929 0.654004088 0.718451067 interferon gamma inducible protein 47 "GO:0003924,GO:0005783,GO:0005789,GO:0006952,GO:0035458" GTPase activity|endoplasmic reticulum|endoplasmic reticulum membrane|defense response|cellular response to interferon-beta mmu04668 TNF signaling pathway Ifih1 0.624862183 -0.678390066 0.002803362 Down 1.626641666 1.548896038 2.147785155 1.138885635 1.03732128 1.118275597 interferon induced with helicase C domain 1 "GO:0000166,GO:0002376,GO:0003677,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0008270,GO:0009615,GO:0016787,GO:0016925,GO:0032727,GO:0032728,GO:0032755,GO:0032760,GO:0039530,GO:0042802,GO:0043021,GO:0045071,GO:0045087,GO:0046872,GO:0051607,GO:0060760,GO:0071360" nucleotide binding|immune system process|DNA binding|RNA binding|RNA helicase activity|double-stranded RNA binding|single-stranded RNA binding|helicase activity|protein binding|ATP binding|nucleus|cytoplasm|mitochondrion|zinc ion binding|response to virus|hydrolase activity|protein sumoylation|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|MDA-5 signaling pathway|identical protein binding|ribonucleoprotein complex binding|negative regulation of viral genome replication|innate immune response|metal ion binding|defense response to virus|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA "mmu04622,mmu05161,mmu05162,mmu05164,mmu05168,mmu05171" RIG-I-like receptor signaling pathway|Hepatitis B|Measles|Influenza A|Herpes simplex virus 1 infection|Coronavirus disease - COVID-19 Ifit1 0.147830128 -2.757987774 6.74E-06 Down 4.600513788 5.84723561 12.72631909 1.236320593 1.117885865 0.763612015 interferon-induced protein with tetratricopeptide repeats 1 "GO:0002376,GO:0003723,GO:0005515,GO:0005737,GO:0005829,GO:0009615,GO:0009617,GO:0035457,GO:0035458,GO:0045087,GO:0051607" immune system process|RNA binding|protein binding|cytoplasm|cytosol|response to virus|response to bacterium|cellular response to interferon-alpha|cellular response to interferon-beta|innate immune response|defense response to virus mmu05160 Hepatitis C Ifit2 0.691365599 -0.532479276 0.003262982 Down 3.710511465 4.178987403 6.202031291 3.449801856 2.825621586 3.268932348 interferon-induced protein with tetratricopeptide repeats 2 "GO:0002376,GO:0003723,GO:0005737,GO:0005783,GO:0005829,GO:0006915,GO:0009615,GO:0032091,GO:0035457,GO:0043065,GO:0045087,GO:0051607" immune system process|RNA binding|cytoplasm|endoplasmic reticulum|cytosol|apoptotic process|response to virus|negative regulation of protein binding|cellular response to interferon-alpha|positive regulation of apoptotic process|innate immune response|defense response to virus Ifit3 0.298913121 -1.742201867 3.00E-08 Down 10.363859 10.8843629 19.3152292 4.419632418 3.382221946 3.876755593 interferon-induced protein with tetratricopeptide repeats 3 "GO:0002376,GO:0003723,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0009617,GO:0035457,GO:0035458,GO:0035634,GO:0042802,GO:0045087,GO:0051607" immune system process|RNA binding|protein binding|cytoplasm|mitochondrion|cytosol|response to bacterium|cellular response to interferon-alpha|cellular response to interferon-beta|response to stilbenoid|identical protein binding|innate immune response|defense response to virus Ifit3b 0.458504584 -1.124991937 3.80E-07 Down 4.519650138 5.853314127 8.416488737 2.757438763 2.713237926 2.892669125 interferon-induced protein with tetratricopeptide repeats 3B "GO:0003723,GO:0005737,GO:0005739,GO:0005829,GO:0042802,GO:0051607" RNA binding|cytoplasm|mitochondrion|cytosol|identical protein binding|defense response to virus Ifitm3 0.354416096 -1.496483969 4.62E-22 Down 43.77917173 41.42408443 47.18001203 16.31681 15.84688238 14.66647528 interferon induced transmembrane protein 3 "GO:0002376,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0005783,GO:0005886,GO:0006898,GO:0008285,GO:0009615,GO:0009986,GO:0016020,GO:0016021,GO:0031410,GO:0031901,GO:0032897,GO:0032991,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0045087,GO:0045177,GO:0046597,GO:0051607,GO:0060337" immune system process|nucleus|cytoplasm|lysosome|lysosomal membrane|endosome|endoplasmic reticulum|plasma membrane|receptor-mediated endocytosis|negative regulation of cell population proliferation|response to virus|cell surface|membrane|integral component of membrane|cytoplasmic vesicle|early endosome membrane|negative regulation of viral transcription|protein-containing complex|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|innate immune response|apical part of cell|negative regulation of viral entry into host cell|defense response to virus|type I interferon signaling pathway Igsf1 1.298364346 0.376695289 0.02747652 Up 2.221677816 2.624611585 2.329588113 3.372135272 3.441064454 2.542786784 "immunoglobulin superfamily, member 1" "GO:0005576,GO:0006355,GO:0015026,GO:0016020,GO:0016021,GO:0032926,GO:0034711,GO:0038102" "extracellular region|regulation of transcription, DNA-templated|coreceptor activity|membrane|integral component of membrane|negative regulation of activin receptor signaling pathway|inhibin binding|activin receptor antagonist activity" Igtp 0.403409249 -1.309683932 1.35E-09 Down 5.973775564 6.159550773 6.65887716 2.652274648 2.316745632 2.604277305 interferon gamma induced GTPase "GO:0003924,GO:0005789,GO:0005829,GO:0006952,GO:0035458" GTPase activity|endoplasmic reticulum membrane|cytosol|defense response|cellular response to interferon-beta mmu05145 Toxoplasmosis Iigp1 0.2057382 -2.281118405 3.39E-10 Down 1.71281983 1.709478849 3.201549989 0.455047121 0.546647846 0.312768598 interferon inducible GTPase 1 "GO:0000166,GO:0002376,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0006952,GO:0009617,GO:0010506,GO:0016020,GO:0016787,GO:0019003,GO:0019221,GO:0020005,GO:0035458,GO:0042802,GO:0042832,GO:0045087,GO:0050829" nucleotide binding|immune system process|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|defense response|response to bacterium|regulation of autophagy|membrane|hydrolase activity|GDP binding|cytokine-mediated signaling pathway|symbiont-containing vacuole membrane|cellular response to interferon-beta|identical protein binding|defense response to protozoan|innate immune response|defense response to Gram-negative bacterium Irf2bp2 0.8062849 -0.310638391 0.004020334 Down 8.759692199 8.655414463 8.928951712 6.689335999 7.245989367 7.29018217 interferon regulatory factor 2 binding protein 2 "GO:0000122,GO:0002327,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0046872" negative regulation of transcription by RNA polymerase II|immature B cell differentiation|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding Irf7 0.103422328 -3.273380416 4.49E-12 Down 10.05417075 7.14586885 15.48334737 0.905492367 1.388036604 0.972459654 interferon regulatory factor 7 "GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0002376,GO:0002819,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0010468,GO:0016064,GO:0032481,GO:0032606,GO:0032727,GO:0032728,GO:0034124,GO:0034127,GO:0045087,GO:0045088,GO:0045893,GO:0045944,GO:0051607,GO:0060337,GO:0060340,GO:1990837" "transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|immune system process|regulation of adaptive immune response|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|regulation of gene expression|immunoglobulin mediated immune response|positive regulation of type I interferon production|type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of MyD88-dependent toll-like receptor signaling pathway|regulation of MyD88-independent toll-like receptor signaling pathway|innate immune response|regulation of innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|defense response to virus|type I interferon signaling pathway|positive regulation of type I interferon-mediated signaling pathway|sequence-specific double-stranded DNA binding" "mmu04620,mmu04621,mmu04622,mmu04623,mmu05160,mmu05161,mmu05162,mmu05164,mmu05167,mmu05168,mmu05169,mmu05203,mmu05417" Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Viral carcinogenesis|Lipid and atherosclerosis Irf9 0.31917271 -1.647590792 8.24E-21 Down 10.32530298 8.25032707 9.024612886 2.583204995 2.938638903 3.266649919 interferon regulatory factor 9 "GO:0000976,GO:0000978,GO:0000981,GO:0002376,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005829,GO:0006355,GO:0006357,GO:0032606,GO:1990837" "transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|immune system process|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|type I interferon production|sequence-specific double-stranded DNA binding" "mmu04217,mmu04380,mmu04621,mmu04625,mmu04630,mmu05160,mmu05162,mmu05164,mmu05165,mmu05167,mmu05168,mmu05169,mmu05171,mmu05203" Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Viral carcinogenesis Irgm1 0.504657975 -0.986622142 1.36E-09 Down 7.553654786 7.454392903 9.649703107 4.255256891 3.83580579 4.27278147 immunity-related GTPase family M member 1 "GO:0000045,GO:0000166,GO:0002376,GO:0003924,GO:0005525,GO:0005764,GO:0005768,GO:0005770,GO:0005776,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006914,GO:0006952,GO:0009617,GO:0016020,GO:0016787,GO:0031410,GO:0035458,GO:0042995,GO:0044754,GO:0045087,GO:0045335,GO:0060335,GO:0071346,GO:0075044,GO:1901098" autophagosome assembly|nucleotide binding|immune system process|GTPase activity|GTP binding|lysosome|endosome|late endosome|autophagosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|autophagy|defense response|response to bacterium|membrane|hydrolase activity|cytoplasmic vesicle|cellular response to interferon-beta|cell projection|autolysosome|innate immune response|phagocytic vesicle|positive regulation of interferon-gamma-mediated signaling pathway|cellular response to interferon-gamma|positive regulation by symbiont of host autophagy|positive regulation of autophagosome maturation mmu05145 Toxoplasmosis Irgm2 0.321578266 -1.63675819 2.09E-12 Down 4.065699047 3.592900117 4.881718849 1.362240664 1.558532314 1.102408222 immunity-related GTPase family M member 2 "GO:0000045,GO:0000139,GO:0001934,GO:0003924,GO:0005739,GO:0005789,GO:0005794,GO:0005829,GO:0006952,GO:0009617,GO:0010508,GO:0010800,GO:0019901,GO:0020003,GO:0031648,GO:0033138,GO:0034341,GO:0035458,GO:0042742,GO:0042832,GO:0043254,GO:0043539,GO:0045087,GO:0050700,GO:0050821,GO:0050829,GO:0051434,GO:0060335,GO:0061635,GO:0061739,GO:0061762,GO:0070431,GO:0071222,GO:0071902,GO:0075044,GO:0098586,GO:1901098" autophagosome assembly|Golgi membrane|positive regulation of protein phosphorylation|GTPase activity|mitochondrion|endoplasmic reticulum membrane|Golgi apparatus|cytosol|defense response|response to bacterium|positive regulation of autophagy|positive regulation of peptidyl-threonine phosphorylation|protein kinase binding|symbiont-containing vacuole|protein destabilization|positive regulation of peptidyl-serine phosphorylation|response to interferon-gamma|cellular response to interferon-beta|defense response to bacterium|defense response to protozoan|regulation of protein-containing complex assembly|protein serine/threonine kinase activator activity|innate immune response|CARD domain binding|protein stabilization|defense response to Gram-negative bacterium|BH3 domain binding|positive regulation of interferon-gamma-mediated signaling pathway|regulation of protein complex stability|protein lipidation involved in autophagosome assembly|CAMKK-AMPK signaling cascade|nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to lipopolysaccharide|positive regulation of protein serine/threonine kinase activity|positive regulation by symbiont of host autophagy|cellular response to virus|positive regulation of autophagosome maturation mmu05145 Toxoplasmosis Irx2 1.838729757 0.878709459 0.029052959 Up 0.311916552 0.227654807 0.177311968 0.429499374 0.368540966 0.502055792 Iroquois homeobox 2 "GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001656,GO:0003677,GO:0005634,GO:0006355,GO:0006357,GO:0030182,GO:0043565,GO:0048468,GO:0072086,GO:0072272" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|metanephros development|DNA binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|neuron differentiation|sequence-specific DNA binding|cell development|specification of loop of Henle identity|proximal/distal pattern formation involved in metanephric nephron development" Isg15 0.158228789 -2.659915976 6.27E-15 Down 9.753791741 8.277555873 17.40103714 1.948275821 1.880728898 1.503085976 ISG15 ubiquitin-like modifier "GO:0005178,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0007229,GO:0009615,GO:0009617,GO:0016567,GO:0019941,GO:0022627,GO:0030501,GO:0031386,GO:0031397,GO:0031625,GO:0032020,GO:0032461,GO:0032649,GO:0032728,GO:0032729,GO:0032733,GO:0034340,GO:0042742,GO:0045071,GO:0045648,GO:0051607,GO:0060339,GO:0070585" integrin binding|protein binding|extracellular region|nucleus|cytoplasm|integrin-mediated signaling pathway|response to virus|response to bacterium|protein ubiquitination|modification-dependent protein catabolic process|cytosolic small ribosomal subunit|positive regulation of bone mineralization|protein tag|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|ISG15-protein conjugation|positive regulation of protein oligomerization|regulation of interferon-gamma production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|response to type I interferon|defense response to bacterium|negative regulation of viral genome replication|positive regulation of erythrocyte differentiation|defense response to virus|negative regulation of type I interferon-mediated signaling pathway|protein localization to mitochondrion "mmu04622,mmu05165,mmu05169,mmu05171" RIG-I-like receptor signaling pathway|Human papillomavirus infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 Islr2 0.728994364 -0.456020434 8.31E-08 Down 15.88180002 15.93544057 16.71057328 12.01165711 11.36042586 11.95716414 immunoglobulin superfamily containing leucine-rich repeat 2 "GO:0005515,GO:0005886,GO:0007275,GO:0007399,GO:0009986,GO:0016020,GO:0016021,GO:0045773" protein binding|plasma membrane|multicellular organism development|nervous system development|cell surface|membrane|integral component of membrane|positive regulation of axon extension Itgad 0.351361414 -1.508972328 0.038970618 Down 0.170976316 0.183283023 0.677681794 0.138000935 0.087913872 0.073911042 "integrin, alpha D" "GO:0007155,GO:0007229,GO:0008305,GO:0016020,GO:0016021,GO:0034113,GO:0044877,GO:0046872,GO:0050798" cell adhesion|integrin-mediated signaling pathway|integrin complex|membrane|integral component of membrane|heterotypic cell-cell adhesion|protein-containing complex binding|metal ion binding|activated T cell proliferation mmu04810 Regulation of actin cytoskeleton Itih3 1.227635267 0.295881997 0.012782422 Up 10.92021467 14.51573878 11.49783805 16.18833119 15.91215119 13.04844321 "inter-alpha trypsin inhibitor, heavy chain 3" "GO:0004867,GO:0005576,GO:0010466,GO:0030212,GO:0030414,GO:0062023" serine-type endopeptidase inhibitor activity|extracellular region|negative regulation of peptidase activity|hyaluronan metabolic process|peptidase inhibitor activity|collagen-containing extracellular matrix Kcna5 0.661515843 -0.596152387 0.006158206 Down 3.288861724 4.073610034 4.20265448 2.800849101 2.611115129 2.217318964 "potassium voltage-gated channel, shaker-related subfamily, member 5" "GO:0005102,GO:0005216,GO:0005244,GO:0005249,GO:0005251,GO:0005267,GO:0005515,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006811,GO:0006813,GO:0007219,GO:0008076,GO:0009986,GO:0014704,GO:0015271,GO:0016020,GO:0016021,GO:0019229,GO:0019870,GO:0019901,GO:0030018,GO:0034705,GO:0034765,GO:0042391,GO:0043266,GO:0043267,GO:0045121,GO:0046691,GO:0048471,GO:0051259,GO:0051260,GO:0051393,GO:0051481,GO:0055075,GO:0055085,GO:0060081,GO:0060372,GO:0071805,GO:0086014,GO:0086050,GO:0086052,GO:0086087,GO:0086089,GO:0086090,GO:0086091,GO:0097110,GO:0097623,GO:0098914,GO:1900087,GO:2000288" signaling receptor binding|ion channel activity|voltage-gated ion channel activity|voltage-gated potassium channel activity|delayed rectifier potassium channel activity|potassium channel activity|protein binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|ion transport|potassium ion transport|Notch signaling pathway|voltage-gated potassium channel complex|cell surface|intercalated disc|outward rectifier potassium channel activity|membrane|integral component of membrane|regulation of vasoconstriction|potassium channel inhibitor activity|protein kinase binding|Z disc|potassium channel complex|regulation of ion transmembrane transport|regulation of membrane potential|regulation of potassium ion transport|negative regulation of potassium ion transport|membrane raft|intracellular canaliculus|perinuclear region of cytoplasm|protein complex oligomerization|protein homooligomerization|alpha-actinin binding|negative regulation of cytosolic calcium ion concentration|potassium ion homeostasis|transmembrane transport|membrane hyperpolarization|regulation of atrial cardiac muscle cell membrane repolarization|potassium ion transmembrane transport|atrial cardiac muscle cell action potential|membrane repolarization during bundle of His cell action potential|membrane repolarization during SA node cell action potential|voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization|voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|voltage-gated potassium channel activity involved in SA node cell action potential repolarization|regulation of heart rate by cardiac conduction|scaffold protein binding|potassium ion export across plasma membrane|membrane repolarization during atrial cardiac muscle cell action potential|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of myoblast proliferation Kcng2 0.770585131 -0.375973746 0.049705994 Down 3.875418045 3.754574191 4.398946924 3.014953749 3.184970914 3.042171938 "potassium voltage-gated channel, subfamily G, member 2" "GO:0005249,GO:0008076,GO:0016021,GO:0071805" voltage-gated potassium channel activity|voltage-gated potassium channel complex|integral component of membrane|potassium ion transmembrane transport Kcnh3 0.821901098 -0.282963294 0.001716404 Down 36.66659228 29.88972649 31.75052772 24.86287177 27.19689188 28.45980882 "potassium voltage-gated channel, subfamily H (eag-related), member 3" "GO:0005216,GO:0005244,GO:0005249,GO:0005267,GO:0005887,GO:0006811,GO:0006813,GO:0016020,GO:0016021,GO:0034765,GO:0042391,GO:0055085,GO:0071805" ion channel activity|voltage-gated ion channel activity|voltage-gated potassium channel activity|potassium channel activity|integral component of plasma membrane|ion transport|potassium ion transport|membrane|integral component of membrane|regulation of ion transmembrane transport|regulation of membrane potential|transmembrane transport|potassium ion transmembrane transport Kcnh4 0.748988731 -0.416984082 0.03896048 Down 3.314306608 3.317966822 2.955430496 2.293223292 2.197117899 2.693779748 "potassium voltage-gated channel, subfamily H (eag-related), member 4" "GO:0005249,GO:0005887,GO:0042391,GO:0071805" voltage-gated potassium channel activity|integral component of plasma membrane|regulation of membrane potential|potassium ion transmembrane transport Kcnj10 1.212236446 0.277671123 0.005605779 Up 23.58626204 20.75194414 17.71300567 23.92451103 25.46066711 25.30205282 "potassium inwardly-rectifying channel, subfamily J, member 10" "GO:0000166,GO:0005102,GO:0005242,GO:0005244,GO:0005267,GO:0005515,GO:0005524,GO:0005886,GO:0005887,GO:0005902,GO:0006811,GO:0006813,GO:0007601,GO:0007628,GO:0014003,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0022010,GO:0034765,GO:0042391,GO:0042802,GO:0044297,GO:0048169,GO:0051930,GO:0051935,GO:0051938,GO:0055075,GO:0060075,GO:0060081,GO:0071805,GO:0097449,GO:0097546,GO:1905515,GO:1990573" nucleotide binding|signaling receptor binding|inward rectifier potassium channel activity|voltage-gated ion channel activity|potassium channel activity|protein binding|ATP binding|plasma membrane|integral component of plasma membrane|microvillus|ion transport|potassium ion transport|visual perception|adult walking behavior|oligodendrocyte development|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|central nervous system myelination|regulation of ion transmembrane transport|regulation of membrane potential|identical protein binding|cell body|regulation of long-term neuronal synaptic plasticity|regulation of sensory perception of pain|glutamate reuptake|L-glutamate import|potassium ion homeostasis|regulation of resting membrane potential|membrane hyperpolarization|potassium ion transmembrane transport|astrocyte projection|ciliary base|non-motile cilium assembly|potassium ion import across plasma membrane "mmu04971,mmu05016" Gastric acid secretion|Huntington disease Kcnj16 1.205000953 0.269034287 0.027429618 Up 7.130595781 6.321119748 6.327655733 7.812513819 8.174808647 7.790807792 "potassium inwardly-rectifying channel, subfamily J, member 16" "GO:0005242,GO:0005244,GO:0005886,GO:0006811,GO:0006813,GO:0006885,GO:0010037,GO:0016020,GO:0016021,GO:0016323,GO:0034765,GO:1990573" inward rectifier potassium channel activity|voltage-gated ion channel activity|plasma membrane|ion transport|potassium ion transport|regulation of pH|response to carbon dioxide|membrane|integral component of membrane|basolateral plasma membrane|regulation of ion transmembrane transport|potassium ion import across plasma membrane mmu04971 Gastric acid secretion Kcnj4 0.818527091 -0.288897928 7.49E-05 Down 27.53390107 22.68835117 22.44709109 20.36708199 19.51768776 19.28621148 "potassium inwardly-rectifying channel, subfamily J, member 4" "GO:0005242,GO:0005244,GO:0005886,GO:0006811,GO:0006813,GO:0016020,GO:0016021,GO:0016323,GO:0030054,GO:0030165,GO:0030425,GO:0031410,GO:0034765,GO:0043025,GO:0045202,GO:0045211,GO:1990573" inward rectifier potassium channel activity|voltage-gated ion channel activity|plasma membrane|ion transport|potassium ion transport|membrane|integral component of membrane|basolateral plasma membrane|cell junction|PDZ domain binding|dendrite|cytoplasmic vesicle|regulation of ion transmembrane transport|neuronal cell body|synapse|postsynaptic membrane|potassium ion import across plasma membrane "mmu04725,mmu04921" Cholinergic synapse|Oxytocin signaling pathway Kdr 1.393691457 0.478911205 0.005331772 Up 2.317815805 1.770750492 1.529711574 2.575509845 2.41044076 2.74622918 kinase insert domain protein receptor "GO:0000166,GO:0001525,GO:0001541,GO:0001569,GO:0001570,GO:0001666,GO:0001934,GO:0001936,GO:0001938,GO:0001945,GO:0002042,GO:0002053,GO:0002244,GO:0003157,GO:0003158,GO:0003416,GO:0004672,GO:0004713,GO:0004714,GO:0005021,GO:0005178,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005768,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006468,GO:0007169,GO:0007204,GO:0007275,GO:0008284,GO:0008360,GO:0008584,GO:0009897,GO:0009986,GO:0010595,GO:0010629,GO:0014068,GO:0016020,GO:0016021,GO:0016239,GO:0016301,GO:0016310,GO:0016477,GO:0016740,GO:0018108,GO:0019838,GO:0030054,GO:0030097,GO:0030154,GO:0030324,GO:0030335,GO:0030513,GO:0030949,GO:0031410,GO:0032008,GO:0033674,GO:0035162,GO:0035584,GO:0035924,GO:0036324,GO:0038033,GO:0038083,GO:0038084,GO:0038085,GO:0042493,GO:0042802,GO:0043005,GO:0043025,GO:0043066,GO:0043129,GO:0043235,GO:0043410,GO:0043491,GO:0043524,GO:0043536,GO:0045121,GO:0045165,GO:0045296,GO:0045446,GO:0045766,GO:0046777,GO:0048010,GO:0048170,GO:0048286,GO:0048469,GO:0048597,GO:0048754,GO:0048812,GO:0050679,GO:0050850,GO:0050927,GO:0051770,GO:0051894,GO:0051901,GO:0055074,GO:0060837,GO:0061042,GO:0070371,GO:0070374,GO:0071944,GO:0090050,GO:0090141,GO:0097443,GO:1901532,GO:1903010,GO:1904881,GO:2000352,GO:2001214" nucleotide binding|angiogenesis|ovarian follicle development|branching involved in blood vessel morphogenesis|vasculogenesis|response to hypoxia|positive regulation of protein phosphorylation|regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|lymph vessel development|cell migration involved in sprouting angiogenesis|positive regulation of mesenchymal cell proliferation|hematopoietic progenitor cell differentiation|endocardium development|endothelium development|endochondral bone growth|protein kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|vascular endothelial growth factor-activated receptor activity|integrin binding|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|endosome|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of cytosolic calcium ion concentration|multicellular organism development|positive regulation of cell population proliferation|regulation of cell shape|male gonad development|external side of plasma membrane|cell surface|positive regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|integral component of membrane|positive regulation of macroautophagy|kinase activity|phosphorylation|cell migration|transferase activity|peptidyl-tyrosine phosphorylation|growth factor binding|cell junction|hemopoiesis|cell differentiation|lung development|positive regulation of cell migration|positive regulation of BMP signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|cytoplasmic vesicle|positive regulation of TOR signaling|positive regulation of kinase activity|embryonic hemopoiesis|calcium-mediated signaling using intracellular calcium source|cellular response to vascular endothelial growth factor stimulus|vascular endothelial growth factor receptor-2 signaling pathway|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|peptidyl-tyrosine autophosphorylation|vascular endothelial growth factor signaling pathway|vascular endothelial growth factor binding|response to drug|identical protein binding|neuron projection|neuronal cell body|negative regulation of apoptotic process|surfactant homeostasis|receptor complex|positive regulation of MAPK cascade|protein kinase B signaling|negative regulation of neuron apoptotic process|positive regulation of blood vessel endothelial cell migration|membrane raft|cell fate commitment|cadherin binding|endothelial cell differentiation|positive regulation of angiogenesis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|lung alveolus development|cell maturation|post-embryonic camera-type eye morphogenesis|branching morphogenesis of an epithelial tube|neuron projection morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of positive chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of focal adhesion assembly|positive regulation of mitochondrial depolarization|calcium ion homeostasis|blood vessel endothelial cell differentiation|vascular wound healing|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cell periphery|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of mitochondrial fission|sorting endosome|regulation of hematopoietic progenitor cell differentiation|regulation of bone development|cellular response to hydrogen sulfide|negative regulation of endothelial cell apoptotic process|positive regulation of vasculogenesis "mmu01521,mmu04010,mmu04014,mmu04015,mmu04020,mmu04151,mmu04370,mmu04510,mmu05205,mmu05418" EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|VEGF signaling pathway|Focal adhesion|Proteoglycans in cancer|Fluid shear stress and atherosclerosis Klf15 0.751996675 -0.411201811 0.001094081 Down 4.69651753 4.633521543 6.109909369 3.843174223 3.819854857 3.847750351 Kruppel-like factor 15 "GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0001678,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0010001,GO:0010468,GO:0014898,GO:0016607,GO:0030111,GO:0032868,GO:0043231,GO:0045893,GO:0045944,GO:0046326,GO:0046872,GO:0072112,GO:1990837,GO:2000757" "transcription cis-regulatory region binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|cellular glucose homeostasis|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|glial cell differentiation|regulation of gene expression|cardiac muscle hypertrophy in response to stress|nuclear speck|regulation of Wnt signaling pathway|response to insulin|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|metal ion binding|glomerular visceral epithelial cell differentiation|sequence-specific double-stranded DNA binding|negative regulation of peptidyl-lysine acetylation" Klf2 0.608996173 -0.715494932 0.000797134 Down 7.500644365 6.559382468 10.9240185 3.649798648 5.915596621 5.60316381 Kruppel-like factor 2 (lung) "GO:0000122,GO:0000785,GO:0000902,GO:0000978,GO:0000981,GO:0001701,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0032715,GO:0034101,GO:0035264,GO:0036003,GO:0040029,GO:0042311,GO:0043249,GO:0045429,GO:0045893,GO:0045944,GO:0046872,GO:0048386,GO:0051247,GO:0060509,GO:0071498,GO:0071499,GO:0097533,GO:1903671,GO:1990837" "negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|in utero embryonic development|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|negative regulation of interleukin-6 production|erythrocyte homeostasis|multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of gene expression, epigenetic|vasodilation|erythrocyte maturation|positive regulation of nitric oxide biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|positive regulation of retinoic acid receptor signaling pathway|positive regulation of protein metabolic process|type I pneumocyte differentiation|cellular response to fluid shear stress|cellular response to laminar fluid shear stress|cellular stress response to acid chemical|negative regulation of sprouting angiogenesis|sequence-specific double-stranded DNA binding" "mmu04068,mmu04371,mmu05418" FoxO signaling pathway|Apelin signaling pathway|Fluid shear stress and atherosclerosis Klhl4 1.224967984 0.292744043 0.032429966 Up 5.50631823 6.511777041 5.060488247 6.754366005 7.192980587 6.85047634 kelch-like 4 "GO:0015630,GO:0034451" microtubule cytoskeleton|centriolar satellite Krt12 0.754748226 -0.405932633 0.023280947 Down 8.442230873 7.353039138 7.970374278 5.50154548 6.348550097 6.067255011 keratin 12 "GO:0002009,GO:0005198,GO:0005882,GO:0060429,GO:0061303" morphogenesis of an epithelium|structural molecule activity|intermediate filament|epithelium development|cornea development in camera-type eye "mmu04915,mmu05150" Estrogen signaling pathway|Staphylococcus aureus infection Ksr1 0.818806109 -0.28840623 0.001856664 Down 10.57526307 10.12310458 10.73130214 8.436241771 8.08853009 9.200267164 kinase suppressor of ras 1 "GO:0000166,GO:0000185,GO:0004672,GO:0004674,GO:0005078,GO:0005515,GO:0005524,GO:0005737,GO:0005783,GO:0005886,GO:0006468,GO:0007165,GO:0007265,GO:0008022,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0019901,GO:0019933,GO:0031434,GO:0032991,GO:0035556,GO:0042127,GO:0042995,GO:0043405,GO:0043410,GO:0046872,GO:0051087,GO:0051879,GO:0071889,GO:0106310,GO:0106311" nucleotide binding|activation of MAPKKK activity|protein kinase activity|protein serine/threonine kinase activity|MAP-kinase scaffold activity|protein binding|ATP binding|cytoplasm|endoplasmic reticulum|plasma membrane|protein phosphorylation|signal transduction|Ras protein signal transduction|protein C-terminus binding|membrane|kinase activity|phosphorylation|transferase activity|protein kinase binding|cAMP-mediated signaling|mitogen-activated protein kinase kinase binding|protein-containing complex|intracellular signal transduction|regulation of cell population proliferation|cell projection|regulation of MAP kinase activity|positive regulation of MAPK cascade|metal ion binding|chaperone binding|Hsp90 protein binding|14-3-3 protein binding|protein serine kinase activity|protein threonine kinase activity "mmu04014,mmu04625,mmu05152" Ras signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis Lcn2 0.16896671 -2.565189058 1.42E-07 Down 4.802570376 4.054250541 3.763030381 1.23337508 0.370413194 0.666080303 lipocalin 2 "GO:0002020,GO:0002376,GO:0005506,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0006811,GO:0006915,GO:0009615,GO:0009617,GO:0009635,GO:0010628,GO:0015891,GO:0031346,GO:0031410,GO:0036094,GO:0042493,GO:0042742,GO:0042802,GO:0045087,GO:0055072,GO:0070301,GO:0097192,GO:0097577,GO:0120162,GO:1903981" protease binding|immune system process|iron ion binding|protein binding|extracellular region|extracellular space|cytosol|ion transport|apoptotic process|response to virus|response to bacterium|response to herbicide|positive regulation of gene expression|siderophore transport|positive regulation of cell projection organization|cytoplasmic vesicle|small molecule binding|response to drug|defense response to bacterium|identical protein binding|innate immune response|iron ion homeostasis|cellular response to hydrogen peroxide|extrinsic apoptotic signaling pathway in absence of ligand|sequestering of iron ion|positive regulation of cold-induced thermogenesis|enterobactin binding mmu04657 IL-17 signaling pathway Ldb2 1.205745414 0.269925323 0.010467779 Up 12.87023377 15.12381219 12.10114206 15.88307626 15.76703282 16.43786839 LIM domain binding 2 "GO:0000122,GO:0001942,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005886,GO:0006357,GO:0007399,GO:0010669,GO:0019899,GO:0030274,GO:0030334,GO:0031252,GO:0035019,GO:0043549,GO:0044089,GO:0045944,GO:0061629" negative regulation of transcription by RNA polymerase II|hair follicle development|transcription coregulator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|plasma membrane|regulation of transcription by RNA polymerase II|nervous system development|epithelial structure maintenance|enzyme binding|LIM domain binding|regulation of cell migration|cell leading edge|somatic stem cell population maintenance|regulation of kinase activity|positive regulation of cellular component biogenesis|positive regulation of transcription by RNA polymerase II|RNA polymerase II-specific DNA-binding transcription factor binding Lgals3bp 0.287530023 -1.798215492 1.03E-14 Down 43.70114477 31.39827917 21.12611553 9.266809964 9.414279319 7.885896678 "lectin, galactoside-binding, soluble, 3 binding protein" "GO:0005044,GO:0005515,GO:0005576,GO:0005615,GO:0007155,GO:0016020" scavenger receptor activity|protein binding|extracellular region|extracellular space|cell adhesion|membrane Lgals9 0.517395372 -0.950660944 7.93E-06 Down 7.845775418 6.783783097 10.81611604 4.709766393 3.917987565 4.331430949 "lectin, galactose binding, soluble 9" "GO:0001819,GO:0002376,GO:0005102,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006935,GO:0007157,GO:0007565,GO:0010628,GO:0010629,GO:0010819,GO:0010862,GO:0016936,GO:0019899,GO:0030246,GO:0032496,GO:0032689,GO:0032722,GO:0032732,GO:0032733,GO:0032755,GO:0032760,GO:0032815,GO:0032823,GO:0033081,GO:0034138,GO:0043032,GO:0043322,GO:0043539,GO:0045089,GO:0045185,GO:0045591,GO:0050728,GO:0051353,GO:0062023,GO:0098586,GO:1900426,GO:2000316,GO:2000406,GO:2000562,GO:2000679" "positive regulation of cytokine production|immune system process|signaling receptor binding|protein binding|extracellular region|nucleus|cytoplasm|cytosol|chemotaxis|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|female pregnancy|positive regulation of gene expression|negative regulation of gene expression|regulation of T cell chemotaxis|positive regulation of pathway-restricted SMAD protein phosphorylation|galactoside binding|enzyme binding|carbohydrate binding|response to lipopolysaccharide|negative regulation of interferon-gamma production|positive regulation of chemokine production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|negative regulation of natural killer cell activation|regulation of natural killer cell differentiation|regulation of T cell differentiation in thymus|toll-like receptor 3 signaling pathway|positive regulation of macrophage activation|negative regulation of natural killer cell degranulation|protein serine/threonine kinase activator activity|positive regulation of innate immune response|maintenance of protein location|positive regulation of regulatory T cell differentiation|negative regulation of inflammatory response|positive regulation of oxidoreductase activity|collagen-containing extracellular matrix|cellular response to virus|positive regulation of defense response to bacterium|regulation of T-helper 17 type immune response|positive regulation of T cell migration|negative regulation of CD4-positive, alpha-beta T cell proliferation|positive regulation of transcription regulatory region DNA binding" Lgr6 0.626949307 -0.673579299 0.015327123 Down 2.280341433 1.441206993 0.694587613 0.991941998 0.718027047 0.824146357 leucine-rich repeat-containing G protein-coupled receptor 6 "GO:0004930,GO:0005615,GO:0005886,GO:0007165,GO:0007186,GO:0016020,GO:0016021,GO:0016055,GO:0016500,GO:0030177,GO:0030335,GO:0031012,GO:0031982,GO:0042246,GO:1990523" G protein-coupled receptor activity|extracellular space|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|membrane|integral component of membrane|Wnt signaling pathway|protein-hormone receptor activity|positive regulation of Wnt signaling pathway|positive regulation of cell migration|extracellular matrix|vesicle|tissue regeneration|bone regeneration mmu04310 Wnt signaling pathway Lhx9 1.486302558 0.571727827 0.013512864 Up 0.710210858 0.709715465 0.667964213 0.995434297 1.145060612 0.965278383 LIM homeobox protein 9 "GO:0000977,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008283,GO:0008584,GO:0008585,GO:0030182,GO:0035262,GO:0046872,GO:1990837" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cell population proliferation|male gonad development|female gonad development|neuron differentiation|gonad morphogenesis|metal ion binding|sequence-specific double-stranded DNA binding" LOC118567843 8.400116585 3.070409351 0.017238442 Up 0 0.050709714 0.04861038 0.218674838 0.535117321 0.095430023 Lrg1 0.449464938 -1.153719519 0.002812906 Down 3.406257648 2.393719623 3.266919327 1.516285617 1.634691193 0.954388394 leucine-rich alpha-2-glycoprotein 1 "GO:0001938,GO:0005160,GO:0005615,GO:0009617,GO:0030511,GO:0043231,GO:0045766,GO:0050873" positive regulation of endothelial cell proliferation|transforming growth factor beta receptor binding|extracellular space|response to bacterium|positive regulation of transforming growth factor beta receptor signaling pathway|intracellular membrane-bounded organelle|positive regulation of angiogenesis|brown fat cell differentiation Ly6a 0.443493587 -1.17301485 3.57E-19 Down 37.05126728 34.23981117 46.94904018 15.48704283 17.23813792 19.43374796 "lymphocyte antigen 6 complex, locus A" "GO:0005515,GO:0005622,GO:0005886,GO:0009617,GO:0009897,GO:0016020,GO:0030550,GO:0031225,GO:0033130,GO:0095500" protein binding|intracellular anatomical structure|plasma membrane|response to bacterium|external side of plasma membrane|membrane|acetylcholine receptor inhibitor activity|anchored component of membrane|acetylcholine receptor binding|acetylcholine receptor signaling pathway Ly6c1 0.698733603 -0.517185571 0.00019413 Down 22.80258853 19.70444235 31.30482598 16.6116149 17.09672656 16.92189884 "lymphocyte antigen 6 complex, locus C1" "GO:0005886,GO:0009897,GO:0009986,GO:0016020,GO:0030550,GO:0031225,GO:0033130,GO:0095500" plasma membrane|external side of plasma membrane|cell surface|membrane|acetylcholine receptor inhibitor activity|anchored component of membrane|acetylcholine receptor binding|acetylcholine receptor signaling pathway Ly6e 0.797247142 -0.326901074 1.63E-06 Down 89.88345791 82.39261904 89.71603063 66.95167902 70.40269834 71.15723343 "lymphocyte antigen 6 complex, locus E" "GO:0001701,GO:0005886,GO:0016020,GO:0030325,GO:0030550,GO:0031225,GO:0033130,GO:0035265,GO:0042415,GO:0046597,GO:0048242,GO:0055010,GO:0095500" in utero embryonic development|plasma membrane|membrane|adrenal gland development|acetylcholine receptor inhibitor activity|anchored component of membrane|acetylcholine receptor binding|organ growth|norepinephrine metabolic process|negative regulation of viral entry into host cell|epinephrine secretion|ventricular cardiac muscle tissue morphogenesis|acetylcholine receptor signaling pathway Mab21l2 2.430039842 1.280979968 0.013579639 Up 0.893952041 0.319432609 0.329762895 0.918323384 1.272901564 1.225393686 mab-21-like 2 "GO:0001654,GO:0005634,GO:0005737,GO:0007275,GO:0008284,GO:0010172,GO:0043010" eye development|nucleus|cytoplasm|multicellular organism development|positive regulation of cell population proliferation|embryonic body morphogenesis|camera-type eye development Mal 0.827711354 -0.272800348 8.58E-07 Down 156.6268302 159.6607571 159.1313195 128.4789018 132.7883967 131.7317771 "myelin and lymphocyte protein, T cell differentiation protein" "GO:0002175,GO:0005783,GO:0005794,GO:0005886,GO:0016020,GO:0016021,GO:0016324,GO:0019898,GO:0019911,GO:0042552,GO:0044853,GO:0045121,GO:0098737,GO:0120003,GO:1902043" protein localization to paranode region of axon|endoplasmic reticulum|Golgi apparatus|plasma membrane|membrane|integral component of membrane|apical plasma membrane|extrinsic component of membrane|structural constituent of myelin sheath|myelination|plasma membrane raft|membrane raft|protein insertion into plasma membrane|hinge region between urothelial plaques of apical plasma membrane|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Mertk 0.773705893 -0.370142832 0.00227596 Down 6.072332571 4.861171962 7.557814347 4.709344171 4.408405635 4.988618642 MER proto-oncogene tyrosine kinase "GO:0000166,GO:0001750,GO:0001779,GO:0001818,GO:0004672,GO:0004713,GO:0004714,GO:0005524,GO:0005615,GO:0005737,GO:0005887,GO:0006468,GO:0006909,GO:0007169,GO:0007275,GO:0007283,GO:0007399,GO:0016020,GO:0016021,GO:0016028,GO:0016301,GO:0016310,GO:0016477,GO:0016740,GO:0030168,GO:0032940,GO:0033674,GO:0034446,GO:0043235,GO:0043277,GO:0043491,GO:0050766,GO:0051250,GO:0060041,GO:0060068,GO:0097350,GO:2000107" nucleotide binding|photoreceptor outer segment|natural killer cell differentiation|negative regulation of cytokine production|protein kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|ATP binding|extracellular space|cytoplasm|integral component of plasma membrane|protein phosphorylation|phagocytosis|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|spermatogenesis|nervous system development|membrane|integral component of membrane|rhabdomere|kinase activity|phosphorylation|cell migration|transferase activity|platelet activation|secretion by cell|positive regulation of kinase activity|substrate adhesion-dependent cell spreading|receptor complex|apoptotic cell clearance|protein kinase B signaling|positive regulation of phagocytosis|negative regulation of lymphocyte activation|retina development in camera-type eye|vagina development|neutrophil clearance|negative regulation of leukocyte apoptotic process Mpz 0.247217308 -2.016148344 0.02602102 Down 1.685944101 0.134872888 0.103431423 0.180945519 0.103509404 0.025381572 myelin protein zero "GO:0005515,GO:0005764,GO:0005791,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016323,GO:0042552,GO:0043066,GO:0043209,GO:0045217,GO:0098742,GO:0098743" protein binding|lysosome|rough endoplasmic reticulum|plasma membrane|integral component of plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|myelination|negative regulation of apoptotic process|myelin sheath|cell-cell junction maintenance|cell-cell adhesion via plasma-membrane adhesion molecules|cell aggregation mmu04514 Cell adhesion molecules Ms4a15 0.122271056 -3.031845161 8.11E-07 Down 4.384093638 1.758374834 0.306469052 1.041652419 0.122680045 0 "membrane-spanning 4-domains, subfamily A, member 15" "GO:0016020,GO:0016021" membrane|integral component of membrane Myo16 0.77893364 -0.360427669 0.000480905 Down 8.866112366 6.327753921 5.798896128 6.075925541 5.05661335 5.007367309 myosin XVI "GO:0000166,GO:0003774,GO:0003779,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0014065,GO:0016459,GO:0019903,GO:0048471,GO:0048812,GO:0051015,GO:2000134" nucleotide binding|motor activity|actin binding|protein binding|ATP binding|nucleoplasm|cytoplasm|phosphatidylinositol 3-kinase signaling|myosin complex|protein phosphatase binding|perinuclear region of cytoplasm|neuron projection morphogenesis|actin filament binding|negative regulation of G1/S transition of mitotic cell cycle Myo7b 9.910356894 3.308937013 0.047404958 Up 0.007769292 0.008328518 0 0.039905513 0.039948725 0.078366712 myosin VIIB "GO:0000146,GO:0000166,GO:0003774,GO:0003779,GO:0005524,GO:0005737,GO:0005856,GO:0005902,GO:0005903,GO:0007015,GO:0007423,GO:0007605,GO:0015629,GO:0016459,GO:0030050,GO:0030154,GO:0031982,GO:0042995,GO:0051015,GO:0090651,GO:1904970" microfilament motor activity|nucleotide binding|motor activity|actin binding|ATP binding|cytoplasm|cytoskeleton|microvillus|brush border|actin filament organization|sensory organ development|sensory perception of sound|actin cytoskeleton|myosin complex|vesicle transport along actin filament|cell differentiation|vesicle|cell projection|actin filament binding|apical cytoplasm|brush border assembly Myoc 1.221053972 0.28812697 0.021252273 Up 13.51580108 13.61775234 11.10601117 15.09820094 16.55764787 14.84980622 myocilin "GO:0001649,GO:0001952,GO:0001953,GO:0001968,GO:0005109,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005783,GO:0005794,GO:0005929,GO:0014068,GO:0014734,GO:0016020,GO:0022011,GO:0030335,GO:0030971,GO:0031175,GO:0031410,GO:0032027,GO:0033268,GO:0035024,GO:0035748,GO:0038031,GO:0038133,GO:0042995,GO:0043220,GO:0043408,GO:0045162,GO:0046872,GO:0051492,GO:0051496,GO:0051497,GO:0051894,GO:0051897,GO:0051901,GO:0060348,GO:0062023,GO:0097453,GO:1900026" osteoblast differentiation|regulation of cell-matrix adhesion|negative regulation of cell-matrix adhesion|fibronectin binding|frizzled binding|protein binding|extracellular region|extracellular space|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum|Golgi apparatus|cilium|positive regulation of phosphatidylinositol 3-kinase signaling|skeletal muscle hypertrophy|membrane|myelination in peripheral nervous system|positive regulation of cell migration|receptor tyrosine kinase binding|neuron projection development|cytoplasmic vesicle|myosin light chain binding|node of Ranvier|negative regulation of Rho protein signal transduction|myelin sheath abaxonal region|non-canonical Wnt signaling pathway via JNK cascade|ERBB2-ERBB3 signaling pathway|cell projection|Schmidt-Lanterman incisure|regulation of MAPK cascade|clustering of voltage-gated sodium channels|metal ion binding|regulation of stress fiber assembly|positive regulation of stress fiber assembly|negative regulation of stress fiber assembly|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|positive regulation of mitochondrial depolarization|bone development|collagen-containing extracellular matrix|mesaxon|positive regulation of substrate adhesion-dependent cell spreading Nab2 0.81498139 -0.295160979 0.014542731 Down 14.97443775 18.33328471 14.34553666 12.66568437 12.61804755 13.29900755 Ngfi-A binding protein 2 "GO:0001958,GO:0003712,GO:0005634,GO:0006355,GO:0008134,GO:0014037,GO:0016480,GO:0042552,GO:0042802,GO:0045682,GO:0045892,GO:1902949" "endochondral ossification|transcription coregulator activity|nucleus|regulation of transcription, DNA-templated|transcription factor binding|Schwann cell differentiation|negative regulation of transcription by RNA polymerase III|myelination|identical protein binding|regulation of epidermis development|negative regulation of transcription, DNA-templated|positive regulation of tau-protein kinase activity" Nav2 0.777278971 -0.363495609 0.001231379 Down 0.515286767 0.442861935 0.439262029 0.335552208 0.366327671 0.381455386 neuron navigator 2 "GO:0003025,GO:0005614,GO:0005654,GO:0007399,GO:0007605,GO:0007608,GO:0007626,GO:0008201,GO:0021554,GO:0021563,GO:0021564,GO:0021695,GO:0031012,GO:0043138" regulation of systemic arterial blood pressure by baroreceptor feedback|interstitial matrix|nucleoplasm|nervous system development|sensory perception of sound|sensory perception of smell|locomotory behavior|heparin binding|optic nerve development|glossopharyngeal nerve development|vagus nerve development|cerebellar cortex development|extracellular matrix|3'-5' DNA helicase activity Nectin3 1.23358138 0.302852895 0.017521059 Up 3.152582202 2.5084963 2.652745434 3.200372931 3.31365708 3.704446134 nectin cell adhesion molecule 3 "GO:0002089,GO:0005515,GO:0005886,GO:0005911,GO:0005912,GO:0007155,GO:0007156,GO:0007157,GO:0007286,GO:0009566,GO:0016020,GO:0016021,GO:0030054,GO:0030424,GO:0030425,GO:0042802,GO:0042803,GO:0043296,GO:0044291,GO:0045202,GO:0045211,GO:0050839,GO:0060042,GO:0061951,GO:0098609,GO:0098686,GO:0099061,GO:1902414" lens morphogenesis in camera-type eye|protein binding|plasma membrane|cell-cell junction|adherens junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|spermatid development|fertilization|membrane|integral component of membrane|cell junction|axon|dendrite|identical protein binding|protein homodimerization activity|apical junction complex|cell-cell contact zone|synapse|postsynaptic membrane|cell adhesion molecule binding|retina morphogenesis in camera-type eye|establishment of protein localization to plasma membrane|cell-cell adhesion|hippocampal mossy fiber to CA3 synapse|integral component of postsynaptic density membrane|protein localization to cell junction "mmu04514,mmu04520" Cell adhesion molecules|Adherens junction Nefh 1.25350663 0.325969626 3.88E-05 Up 25.83448282 23.04857432 23.24060562 29.77876667 30.52299628 29.88648379 "neurofilament, heavy polypeptide" "GO:0000226,GO:0001552,GO:0005200,GO:0005634,GO:0005737,GO:0005739,GO:0005856,GO:0005882,GO:0005883,GO:0007420,GO:0014069,GO:0015643,GO:0019901,GO:0030424,GO:0030674,GO:0031103,GO:0033693,GO:0042995,GO:0043025,GO:0043204,GO:0043209,GO:0044877,GO:0045104,GO:0045110,GO:0048936,GO:0060052,GO:0061564,GO:0097418,GO:0097440,GO:0098685,GO:0099160,GO:0099184,GO:0150017,GO:1902513,GO:1903935,GO:1990830" microtubule cytoskeleton organization|ovarian follicle atresia|structural constituent of cytoskeleton|nucleus|cytoplasm|mitochondrion|cytoskeleton|intermediate filament|neurofilament|brain development|postsynaptic density|toxic substance binding|protein kinase binding|axon|protein-macromolecule adaptor activity|axon regeneration|neurofilament bundle assembly|cell projection|neuronal cell body|perikaryon|myelin sheath|protein-containing complex binding|intermediate filament cytoskeleton organization|intermediate filament bundle assembly|peripheral nervous system neuron axonogenesis|neurofilament cytoskeleton organization|axon development|neurofibrillary tangle|apical dendrite|Schaffer collateral - CA1 synapse|postsynaptic intermediate filament cytoskeleton|structural constituent of postsynaptic intermediate filament cytoskeleton|basal proximal dendrite|regulation of organelle transport along microtubule|response to sodium arsenite|cellular response to leukemia inhibitory factor "mmu05014,mmu05022" Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases Neurl1b 0.811612623 -0.301136791 0.003520702 Down 7.893760915 7.58687406 7.851587627 6.59115407 6.052631115 6.274261584 neuralized E3 ubiquitin protein ligase 1B "GO:0005515,GO:0005737,GO:0005769,GO:0005829,GO:0007219,GO:0015629,GO:0016740,GO:0046872,GO:0061630,GO:0070086" protein binding|cytoplasm|early endosome|cytosol|Notch signaling pathway|actin cytoskeleton|transferase activity|metal ion binding|ubiquitin protein ligase activity|ubiquitin-dependent endocytosis Nfkbia 0.709357177 -0.495415855 0.002415933 Down 13.8152978 10.77701851 16.56270167 8.728374389 9.571587981 10.56582297 "nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha" "GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006606,GO:0007249,GO:0007253,GO:0008139,GO:0010468,GO:0010745,GO:0010875,GO:0010888,GO:0019899,GO:0031072,GO:0031625,GO:0031663,GO:0032088,GO:0032270,GO:0032495,GO:0032496,GO:0032991,GO:0033209,GO:0034142,GO:0035994,GO:0042127,GO:0042802,GO:0042994,GO:0043330,GO:0044877,GO:0045638,GO:0045746,GO:0045893,GO:0045944,GO:0050729,GO:0051059,GO:0070427,GO:0070431,GO:0071216,GO:0071345,GO:0071356,GO:0071407" "protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein import into nucleus|I-kappaB kinase/NF-kappaB signaling|cytoplasmic sequestering of NF-kappaB|nuclear localization sequence binding|regulation of gene expression|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of lipid storage|enzyme binding|heat shock protein binding|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of cellular protein metabolic process|response to muramyl dipeptide|response to lipopolysaccharide|protein-containing complex|tumor necrosis factor-mediated signaling pathway|toll-like receptor 4 signaling pathway|response to muscle stretch|regulation of cell population proliferation|identical protein binding|cytoplasmic sequestering of transcription factor|response to exogenous dsRNA|protein-containing complex binding|negative regulation of myeloid cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|positive regulation of inflammatory response|NF-kappaB binding|nucleotide-binding oligomerization domain containing 1 signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to biotic stimulus|cellular response to cytokine stimulus|cellular response to tumor necrosis factor|cellular response to organic cyclic compound" "mmu04024,mmu04062,mmu04064,mmu04210,mmu04380,mmu04620,mmu04621,mmu04622,mmu04623,mmu04625,mmu04657,mmu04658,mmu04659,mmu04660,mmu04662,mmu04668,mmu04722,mmu04920,mmu04926,mmu04931,mmu05132,mmu05134,mmu05135,mmu05140,mmu05142,mmu05145,mmu05160,mmu05161,mmu05162,mmu05163,mmu05164,mmu05166,mmu05167,mmu05168,mmu05169,mmu05170,mmu05171,mmu05200,mmu05203,mmu05215,mmu05220,mmu05222,mmu05235,mmu05417" cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Salmonella infection|Legionellosis|Yersinia infection|Leishmaniasis|Chagas disease|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Coronavirus disease - COVID-19|Pathways in cancer|Viral carcinogenesis|Prostate cancer|Chronic myeloid leukemia|Small cell lung cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Lipid and atherosclerosis Nlrc5 0.221086768 -2.17731541 1.55E-05 Down 0.317173926 0.298370675 0.452308187 0.086442272 0.053252847 0.097936101 "NLR family, CARD domain containing 5" "GO:0000166,GO:0000978,GO:0002376,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0009617,GO:0032088,GO:0035556,GO:0043549,GO:0045087,GO:0045345,GO:0045944,GO:0060335,GO:0060339,GO:0060340" nucleotide binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|immune system process|ATP binding|nucleus|cytoplasm|centrosome|cytosol|response to bacterium|negative regulation of NF-kappaB transcription factor activity|intracellular signal transduction|regulation of kinase activity|innate immune response|positive regulation of MHC class I biosynthetic process|positive regulation of transcription by RNA polymerase II|positive regulation of interferon-gamma-mediated signaling pathway|negative regulation of type I interferon-mediated signaling pathway|positive regulation of type I interferon-mediated signaling pathway Nmb 0.505291593 -0.984811917 0.010270069 Down 9.397891103 6.028740115 2.35728732 3.800827108 2.511262285 1.940663291 neuromedin B "GO:0005184,GO:0005576,GO:0007204,GO:0007218,GO:0008284,GO:0031710,GO:0042593,GO:0043005,GO:0046887,GO:0046888,GO:0050482" neuropeptide hormone activity|extracellular region|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|positive regulation of cell population proliferation|neuromedin B receptor binding|glucose homeostasis|neuron projection|positive regulation of hormone secretion|negative regulation of hormone secretion|arachidonic acid secretion mmu04080 Neuroactive ligand-receptor interaction Nr1d1 0.699624853 -0.515346556 6.41E-09 Down 50.91055211 50.31882649 57.17738702 40.2340134 36.61424824 33.89161823 "nuclear receptor subfamily 1, group D, member 1" "GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0001222,GO:0001227,GO:0001678,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005978,GO:0006355,GO:0007623,GO:0008270,GO:0009755,GO:0010498,GO:0016604,GO:0019216,GO:0020037,GO:0030054,GO:0030154,GO:0030425,GO:0031648,GO:0032922,GO:0034144,GO:0042632,GO:0042749,GO:0042752,GO:0042753,GO:0042995,GO:0043025,GO:0043124,GO:0043197,GO:0043565,GO:0044321,GO:0045202,GO:0045598,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048511,GO:0050728,GO:0060086,GO:0061178,GO:0061469,GO:0061889,GO:0070859,GO:0070888,GO:0071222,GO:0071347,GO:0071356,GO:0120163,GO:0150079,GO:1903979,GO:1990837,GO:2000489" "negative regulation of transcription by RNA polymerase II|chromatin|transcription cis-regulatory region binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription corepressor binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|cellular glucose homeostasis|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|glycogen biosynthetic process|regulation of transcription, DNA-templated|circadian rhythm|zinc ion binding|hormone-mediated signaling pathway|proteasomal protein catabolic process|nuclear body|regulation of lipid metabolic process|heme binding|cell junction|cell differentiation|dendrite|protein destabilization|circadian regulation of gene expression|negative regulation of toll-like receptor 4 signaling pathway|cholesterol homeostasis|regulation of circadian sleep/wake cycle|regulation of circadian rhythm|positive regulation of circadian rhythm|cell projection|neuronal cell body|negative regulation of I-kappaB kinase/NF-kappaB signaling|dendritic spine|sequence-specific DNA binding|response to leptin|synapse|regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|rhythmic process|negative regulation of inflammatory response|circadian temperature homeostasis|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of type B pancreatic cell proliferation|negative regulation of astrocyte activation|positive regulation of bile acid biosynthetic process|E-box binding|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|negative regulation of cold-induced thermogenesis|negative regulation of neuroinflammatory response|negative regulation of microglial cell activation|sequence-specific double-stranded DNA binding|regulation of hepatic stellate cell activation" mmu04710 Circadian rhythm Nr4a1 0.6393748 -0.645266211 0.043805433 Down 19.84124579 24.68750403 16.20837827 10.53506477 12.02667942 16.39378076 "nuclear receptor subfamily 4, group A, member 1" "GO:0000978,GO:0000981,GO:0001228,GO:0001938,GO:0002042,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005739,GO:0005829,GO:0006355,GO:0006357,GO:0006915,GO:0008134,GO:0008270,GO:0010035,GO:0031965,GO:0035259,GO:0035767,GO:0035914,GO:0035924,GO:0042802,GO:0043065,GO:0043154,GO:0043565,GO:0044344,GO:0045444,GO:0045786,GO:0045893,GO:0045944,GO:0046872,GO:0046982,GO:0061469,GO:0071310,GO:0071376,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|mitochondrion|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|apoptotic process|transcription factor binding|zinc ion binding|response to inorganic substance|nuclear membrane|glucocorticoid receptor binding|endothelial cell chemotaxis|skeletal muscle cell differentiation|cellular response to vascular endothelial growth factor stimulus|identical protein binding|positive regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|sequence-specific DNA binding|cellular response to fibroblast growth factor stimulus|fat cell differentiation|negative regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|metal ion binding|protein heterodimerization activity|regulation of type B pancreatic cell proliferation|cellular response to organic substance|cellular response to corticotropin-releasing hormone stimulus|sequence-specific double-stranded DNA binding" "mmu04010,mmu04151,mmu04925,mmu04927,mmu04934" MAPK signaling pathway|PI3K-Akt signaling pathway|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome Ntng1 1.226705286 0.294788685 0.005093817 Up 3.809824318 4.354817575 4.351895817 5.492138928 4.775109444 5.061541259 netrin G1 "GO:0005515,GO:0005886,GO:0007275,GO:0007399,GO:0007409,GO:0009887,GO:0009888,GO:0010975,GO:0016020,GO:0016477,GO:0030154,GO:0031225,GO:0034446,GO:0043256,GO:0046658,GO:0050804,GO:0050839,GO:0070831,GO:0098632,GO:0098685,GO:0098978,GO:0099029,GO:0099560,GO:0150011,GO:2001222" protein binding|plasma membrane|multicellular organism development|nervous system development|axonogenesis|animal organ morphogenesis|tissue development|regulation of neuron projection development|membrane|cell migration|cell differentiation|anchored component of membrane|substrate adhesion-dependent cell spreading|laminin complex|anchored component of plasma membrane|modulation of chemical synaptic transmission|cell adhesion molecule binding|basement membrane assembly|cell-cell adhesion mediator activity|Schaffer collateral - CA1 synapse|glutamatergic synapse|anchored component of presynaptic active zone membrane|synaptic membrane adhesion|regulation of neuron projection arborization|regulation of neuron migration "mmu04360,mmu04514" Axon guidance|Cell adhesion molecules Oas1a 0.244747133 -2.030636137 4.17E-05 Down 1.1835302 1.043169396 2.351311792 0.270176924 0.378657282 0.424460194 2'-5' oligoadenylate synthetase 1A "GO:0001730,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005840,GO:0006164,GO:0009615,GO:0016020,GO:0045071,GO:0048525,GO:0051607,GO:0060700" 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|ribosome|purine nucleotide biosynthetic process|response to virus|membrane|negative regulation of viral genome replication|negative regulation of viral process|defense response to virus|regulation of ribonuclease activity "mmu04621,mmu05160,mmu05162,mmu05164,mmu05168,mmu05169,mmu05171" NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 Oas2 0.347599604 -1.524501657 0.02818157 Down 0.288881617 0.242354372 0.361388427 0.090317422 0.103331683 0.114020971 2'-5' oligoadenylate synthetase 2 "GO:0000166,GO:0001730,GO:0002376,GO:0003723,GO:0003725,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006401,GO:0009615,GO:0009617,GO:0016020,GO:0016740,GO:0016779,GO:0032728,GO:0032760,GO:0042742,GO:0045071,GO:0045087,GO:0046872,GO:0048471,GO:0051607,GO:0060337,GO:0060700,GO:0070106,GO:1903487" nucleotide binding|2'-5'-oligoadenylate synthetase activity|immune system process|RNA binding|double-stranded RNA binding|ATP binding|nucleoplasm|cytoplasm|cytosol|RNA catabolic process|response to virus|response to bacterium|membrane|transferase activity|nucleotidyltransferase activity|positive regulation of interferon-beta production|positive regulation of tumor necrosis factor production|defense response to bacterium|negative regulation of viral genome replication|innate immune response|metal ion binding|perinuclear region of cytoplasm|defense response to virus|type I interferon signaling pathway|regulation of ribonuclease activity|interleukin-27-mediated signaling pathway|regulation of lactation "mmu04621,mmu05160,mmu05162,mmu05164,mmu05168,mmu05169,mmu05171" NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19 Oasl1 0.161152634 -2.633500323 0.000779047 Down 0.497598474 0.242461419 1.650208603 0.023234738 0.162819286 0.159699867 2'-5' oligoadenylate synthetase-like 1 "GO:0001730,GO:0002376,GO:0003677,GO:0003723,GO:0003725,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0009615,GO:0016020,GO:0016779,GO:0045071,GO:0045087,GO:0051607,GO:0060700,GO:0070106,GO:1900246" 2'-5'-oligoadenylate synthetase activity|immune system process|DNA binding|RNA binding|double-stranded RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|response to virus|membrane|nucleotidyltransferase activity|negative regulation of viral genome replication|innate immune response|defense response to virus|regulation of ribonuclease activity|interleukin-27-mediated signaling pathway|positive regulation of RIG-I signaling pathway mmu05165 Human papillomavirus infection Oasl2 0.184108714 -2.441370182 4.67E-30 Down 6.037912734 5.047858741 7.216172746 1.162972719 1.113613266 1.059178466 2'-5' oligoadenylate synthetase-like 2 "GO:0000166,GO:0001730,GO:0002376,GO:0003723,GO:0003725,GO:0005524,GO:0005654,GO:0005829,GO:0006164,GO:0009615,GO:0016020,GO:0016740,GO:0016779,GO:0045071,GO:0045087,GO:0046872,GO:0051607,GO:0060700,GO:0070106" nucleotide binding|2'-5'-oligoadenylate synthetase activity|immune system process|RNA binding|double-stranded RNA binding|ATP binding|nucleoplasm|cytosol|purine nucleotide biosynthetic process|response to virus|membrane|transferase activity|nucleotidyltransferase activity|negative regulation of viral genome replication|innate immune response|metal ion binding|defense response to virus|regulation of ribonuclease activity|interleukin-27-mediated signaling pathway mmu05165 Human papillomavirus infection Ogfr 0.817798418 -0.290182823 0.007644747 Down 19.82979607 18.21385542 17.81077027 15.17364962 15.82665902 14.59763107 opioid growth factor receptor "GO:0004985,GO:0005634,GO:0005737,GO:0016020,GO:0038023,GO:0040008" G protein-coupled opioid receptor activity|nucleus|cytoplasm|membrane|signaling receptor activity|regulation of growth Otop2 0.405435903 -1.302454243 0.015476954 Down 1.03036923 0.854450978 0.39955001 0.399418733 0.279895872 0.215704821 otopetrin 2 "GO:0005886,GO:0006811,GO:0015252,GO:0016020,GO:0016021,GO:1902600" plasma membrane|ion transport|proton channel activity|membrane|integral component of membrane|proton transmembrane transport Papss2 1.28928944 0.366576179 0.016067914 Up 3.934927054 4.175262687 4.838530846 5.53576261 5.528039823 5.556673471 3'-phosphoadenosine 5'-phosphosulfate synthase 2 "GO:0000103,GO:0000166,GO:0003824,GO:0004020,GO:0004781,GO:0005524,GO:0007596,GO:0008152,GO:0016301,GO:0016310,GO:0016740,GO:0016779,GO:0050428,GO:0060348" sulfate assimilation|nucleotide binding|catalytic activity|adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|ATP binding|blood coagulation|metabolic process|kinase activity|phosphorylation|transferase activity|nucleotidyltransferase activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|bone development "mmu00230,mmu00450,mmu00920" Purine metabolism|Selenocompound metabolism|Sulfur metabolism Parp12 0.589482551 -0.762478986 0.000109135 Down 3.901214628 4.641022427 6.437036495 2.883496485 2.870310315 2.895299313 "poly (ADP-ribose) polymerase family, member 12" "GO:0003950,GO:0005634,GO:0006471,GO:0016740,GO:0046872,GO:0070213,GO:0140289,GO:1990404" NAD+ ADP-ribosyltransferase activity|nucleus|protein ADP-ribosylation|transferase activity|metal ion binding|protein auto-ADP-ribosylation|protein mono-ADP-ribosylation|protein ADP-ribosylase activity Parp14 0.333569238 -1.583941846 3.12E-09 Down 0.987487654 0.91301321 2.19438047 0.393083491 0.399856066 0.479349824 "poly (ADP-ribose) polymerase family, member 14" "GO:0002376,GO:0003714,GO:0003950,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006471,GO:0010629,GO:0016740,GO:0016757,GO:0019899,GO:0042531,GO:0042532,GO:0045087,GO:0060336,GO:0070212,GO:0070403,GO:0140289,GO:1902216,GO:1990404" immune system process|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein ADP-ribosylation|negative regulation of gene expression|transferase activity|glycosyltransferase activity|enzyme binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|innate immune response|negative regulation of interferon-gamma-mediated signaling pathway|protein poly-ADP-ribosylation|NAD+ binding|protein mono-ADP-ribosylation|positive regulation of interleukin-4-mediated signaling pathway|protein ADP-ribosylase activity Parp9 0.398638519 -1.326846977 4.42E-06 Down 1.714329228 1.627298433 2.797115551 0.752822142 0.847842008 0.778798491 "poly (ADP-ribose) polymerase family, member 9" "GO:0000122,GO:0002230,GO:0002376,GO:0003714,GO:0003950,GO:0004857,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006281,GO:0006302,GO:0006471,GO:0006974,GO:0010608,GO:0010629,GO:0016740,GO:0019899,GO:0032991,GO:0035563,GO:0042393,GO:0042531,GO:0043086,GO:0044389,GO:0045087,GO:0045893,GO:0051607,GO:0060330,GO:0060335,GO:0070212,GO:0072570,GO:0090734,GO:0097677,GO:0140289,GO:1900182,GO:1990404,GO:2001034" "negative regulation of transcription by RNA polymerase II|positive regulation of defense response to virus by host|immune system process|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|enzyme inhibitor activity|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|DNA repair|double-strand break repair|protein ADP-ribosylation|cellular response to DNA damage stimulus|posttranscriptional regulation of gene expression|negative regulation of gene expression|transferase activity|enzyme binding|protein-containing complex|positive regulation of chromatin binding|histone binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of catalytic activity|ubiquitin-like protein ligase binding|innate immune response|positive regulation of transcription, DNA-templated|defense response to virus|regulation of response to interferon-gamma|positive regulation of interferon-gamma-mediated signaling pathway|protein poly-ADP-ribosylation|ADP-D-ribose binding|site of DNA damage|STAT family protein binding|protein mono-ADP-ribosylation|positive regulation of protein localization to nucleus|protein ADP-ribosylase activity|positive regulation of double-strand break repair via nonhomologous end joining" Pcsk9 0.672998705 -0.571324365 0.047513932 Down 1.633038025 1.703691889 1.648143791 0.853757542 1.289520269 1.250107486 proprotein convertase subtilisin/kexin type 9 "GO:0001822,GO:0001889,GO:0001920,GO:0002092,GO:0004252,GO:0005576,GO:0005615,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005783,GO:0005788,GO:0005791,GO:0005794,GO:0005886,GO:0006508,GO:0006629,GO:0006641,GO:0006644,GO:0006915,GO:0007041,GO:0008202,GO:0008203,GO:0008233,GO:0008236,GO:0009267,GO:0009986,GO:0010469,GO:0010989,GO:0016485,GO:0016540,GO:0016787,GO:0019871,GO:0022008,GO:0030134,GO:0030169,GO:0030182,GO:0030547,GO:0032799,GO:0032802,GO:0032803,GO:0032805,GO:0032869,GO:0034185,GO:0034189,GO:0034190,GO:0042157,GO:0042632,GO:0043523,GO:0043525,GO:0043621,GO:0048471,GO:0050750,GO:0070326,GO:1905596,GO:1905598,GO:1905601,GO:1990666,GO:1990667,GO:2000650" kidney development|liver development|negative regulation of receptor recycling|positive regulation of receptor internalization|serine-type endopeptidase activity|extracellular region|extracellular space|cytoplasm|lysosome|endosome|early endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum lumen|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|proteolysis|lipid metabolic process|triglyceride metabolic process|phospholipid metabolic process|apoptotic process|lysosomal transport|steroid metabolic process|cholesterol metabolic process|peptidase activity|serine-type peptidase activity|cellular response to starvation|cell surface|regulation of signaling receptor activity|negative regulation of low-density lipoprotein particle clearance|protein processing|protein autoprocessing|hydrolase activity|sodium channel inhibitor activity|neurogenesis|COPII-coated ER to Golgi transport vesicle|low-density lipoprotein particle binding|neuron differentiation|signaling receptor inhibitor activity|low-density lipoprotein receptor particle metabolic process|low-density lipoprotein particle receptor catabolic process|regulation of low-density lipoprotein particle receptor catabolic process|positive regulation of low-density lipoprotein particle receptor catabolic process|cellular response to insulin stimulus|apolipoprotein binding|very-low-density lipoprotein particle binding|apolipoprotein receptor binding|lipoprotein metabolic process|cholesterol homeostasis|regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|protein self-association|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|very-low-density lipoprotein particle receptor binding|negative regulation of low-density lipoprotein particle receptor binding|negative regulation of low-density lipoprotein receptor activity|negative regulation of receptor-mediated endocytosis involved in cholesterol transport|PCSK9-LDLR complex|PCSK9-AnxA2 complex|negative regulation of sodium ion transmembrane transporter activity mmu04979 Cholesterol metabolism Pdia6 1.200884612 0.264097535 0.000572709 Up 42.4501288 44.43131489 41.26780019 50.10319014 52.48863706 51.04978158 protein disulfide isomerase associated 6 "GO:0003756,GO:0005615,GO:0005783,GO:0005788,GO:0005790,GO:0005793,GO:0005829,GO:0005886,GO:0015035,GO:0016020,GO:0016853,GO:0034663,GO:1903895" protein disulfide isomerase activity|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|protein-disulfide reductase activity|membrane|isomerase activity|endoplasmic reticulum chaperone complex|negative regulation of IRE1-mediated unfolded protein response mmu04141 Protein processing in endoplasmic reticulum Per1 0.677235437 -0.56227063 0.025564901 Down 8.931383882 12.31438485 11.40095254 8.485828687 6.419424432 7.131491017 period circadian clock 1 "GO:0000122,GO:0000976,GO:0000978,GO:0001222,GO:0002028,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007623,GO:0008134,GO:0009416,GO:0010608,GO:0019900,GO:0031490,GO:0031625,GO:0032922,GO:0042634,GO:0042752,GO:0043124,GO:0043153,GO:0043966,GO:0043967,GO:0045892,GO:0045944,GO:0046329,GO:0048511,GO:0051591,GO:0070888,GO:0070932,GO:0097167,GO:1900015,GO:1900744,GO:2000323" "negative regulation of transcription by RNA polymerase II|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|transcription corepressor binding|regulation of sodium ion transport|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|circadian rhythm|transcription factor binding|response to light stimulus|posttranscriptional regulation of gene expression|kinase binding|chromatin DNA binding|ubiquitin protein ligase binding|circadian regulation of gene expression|regulation of hair cycle|regulation of circadian rhythm|negative regulation of I-kappaB kinase/NF-kappaB signaling|entrainment of circadian clock by photoperiod|histone H3 acetylation|histone H4 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|rhythmic process|response to cAMP|E-box binding|histone H3 deacetylation|circadian regulation of translation|regulation of cytokine production involved in inflammatory response|regulation of p38MAPK cascade|negative regulation of glucocorticoid receptor signaling pathway" "mmu04710,mmu04713" Circadian rhythm|Circadian entrainment Phf11b 0.234180608 -2.094306478 0.001534266 Down 0.696225787 0.895607319 1.717060056 0.178801656 0.250593381 0.316018694 PHD finger protein 11B "GO:0005634,GO:0005654,GO:0031965" nucleus|nucleoplasm|nuclear membrane Phf11d 0.26728959 -1.903524443 0.002587612 Down 0.591001342 0.347425729 1.253807566 0.137090145 0.215660648 0.173069061 PHD finger protein 11D "GO:0005634,GO:0005654,GO:0031965,GO:0046872" nucleus|nucleoplasm|nuclear membrane|metal ion binding Pik3ip1 0.796091317 -0.328994167 0.006849956 Down 17.69315209 16.81305093 21.86470184 15.24397711 14.69702012 14.62269391 phosphoinositide-3-kinase interacting protein 1 "GO:0004252,GO:0005886,GO:0014067,GO:0016020,GO:0016021,GO:0036313,GO:0043553" serine-type endopeptidase activity|plasma membrane|negative regulation of phosphatidylinositol 3-kinase signaling|membrane|integral component of membrane|phosphatidylinositol 3-kinase catalytic subunit binding|negative regulation of phosphatidylinositol 3-kinase activity Pim3 0.81828066 -0.289332341 0.012184064 Down 22.43896281 19.3567405 20.38264982 15.2656552 18.00337261 17.57304027 proviral integration site 3 "GO:0000166,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007049,GO:0007346,GO:0016301,GO:0016310,GO:0016572,GO:0016740,GO:0043066,GO:0046777,GO:0061179,GO:0106310,GO:0106311" nucleotide binding|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|apoptotic process|cell cycle|regulation of mitotic cell cycle|kinase activity|phosphorylation|histone phosphorylation|transferase activity|negative regulation of apoptotic process|protein autophosphorylation|negative regulation of insulin secretion involved in cellular response to glucose stimulus|protein serine kinase activity|protein threonine kinase activity Pla2g4e 0.645222116 -0.632132206 0.012218621 Down 1.762457675 1.465652473 1.734267071 1.108249513 1.153388185 0.937355129 "phospholipase A2, group IVE" "GO:0004620,GO:0004623,GO:0005509,GO:0005544,GO:0005546,GO:0005547,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0005829,GO:0005886,GO:0006629,GO:0009395,GO:0010314,GO:0016020,GO:0016042,GO:0016410,GO:0016740,GO:0016787,GO:0031901,GO:0032266,GO:0043325,GO:0046475,GO:0046872,GO:0047498,GO:0070273,GO:0070292,GO:0080025,GO:0102567,GO:0102568,GO:2001137" "phospholipase activity|phospholipase A2 activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|lysosome|lysosomal membrane|endosome|cytosol|plasma membrane|lipid metabolic process|phospholipid catabolic process|phosphatidylinositol-5-phosphate binding|membrane|lipid catabolic process|N-acyltransferase activity|transferase activity|hydrolase activity|early endosome membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-3,4-bisphosphate binding|glycerophospholipid catabolic process|metal ion binding|calcium-dependent phospholipase A2 activity|phosphatidylinositol-4-phosphate binding|N-acylphosphatidylethanolamine metabolic process|phosphatidylinositol-3,5-bisphosphate binding|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|positive regulation of endocytic recycling" "mmu00564,mmu00565,mmu00590,mmu00591,mmu00592,mmu04010,mmu04014,mmu04072,mmu04217,mmu04270,mmu04370,mmu04611,mmu04664,mmu04666,mmu04724,mmu04726,mmu04730,mmu04750,mmu04912,mmu04913,mmu04921,mmu05231" Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer Plat 0.816960012 -0.29166263 0.0115989 Down 14.72429758 13.05703562 14.18007045 11.60166355 11.0592805 11.54723031 "plasminogen activator, tissue" "GO:0001666,GO:0004252,GO:0005102,GO:0005576,GO:0005615,GO:0005737,GO:0006508,GO:0008233,GO:0008236,GO:0009986,GO:0014909,GO:0016787,GO:0030141,GO:0031639,GO:0035249,GO:0045177,GO:0045202,GO:0045861,GO:0048008,GO:0051219,GO:0060279,GO:0098685,GO:0098794,GO:0098978,GO:0098992,GO:0099183,GO:0099544" "response to hypoxia|serine-type endopeptidase activity|signaling receptor binding|extracellular region|extracellular space|cytoplasm|proteolysis|peptidase activity|serine-type peptidase activity|cell surface|smooth muscle cell migration|hydrolase activity|secretory granule|plasminogen activation|synaptic transmission, glutamatergic|apical part of cell|synapse|negative regulation of proteolysis|platelet-derived growth factor receptor signaling pathway|phosphoprotein binding|positive regulation of ovulation|Schaffer collateral - CA1 synapse|postsynapse|glutamatergic synapse|neuronal dense core vesicle|trans-synaptic signaling by BDNF, modulating synaptic transmission|perisynaptic space" "mmu04371,mmu04610,mmu05202,mmu05215,mmu05418" Apelin signaling pathway|Complement and coagulation cascades|Transcriptional misregulation in cancer|Prostate cancer|Fluid shear stress and atherosclerosis Plekha1 0.830868019 -0.267308768 0.001217916 Down 19.78073631 20.73405176 19.36174591 17.58341258 15.88104425 16.23568175 "pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1" "GO:0001553,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007283,GO:0008209,GO:0008210,GO:0008289,GO:0008585,GO:0009791,GO:0014065,GO:0016020,GO:0030165,GO:0031529,GO:0032587,GO:0033327,GO:0035264,GO:0043325,GO:0045184,GO:0048008,GO:0048705,GO:0050853,GO:0051898,GO:0060021,GO:0060325,GO:0070301" "luteinization|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|spermatogenesis|androgen metabolic process|estrogen metabolic process|lipid binding|female gonad development|post-embryonic development|phosphatidylinositol 3-kinase signaling|membrane|PDZ domain binding|ruffle organization|ruffle membrane|Leydig cell differentiation|multicellular organism growth|phosphatidylinositol-3,4-bisphosphate binding|establishment of protein localization|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|B cell receptor signaling pathway|negative regulation of protein kinase B signaling|roof of mouth development|face morphogenesis|cellular response to hydrogen peroxide" Plekhf1 0.613540392 -0.704769768 0.023482507 Down 2.528171916 1.73858502 3.700852903 1.543557137 1.496173711 1.659969023 "pleckstrin homology domain containing, family F (with FYVE domain) member 1" "GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0006915,GO:0007032,GO:0010314,GO:0010508,GO:0016050,GO:0032266,GO:0035091,GO:0046872,GO:0046902,GO:0070273,GO:0072659,GO:2001244" nucleus|cytoplasm|lysosome|endosome|apoptotic process|endosome organization|phosphatidylinositol-5-phosphate binding|positive regulation of autophagy|vesicle organization|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|metal ion binding|regulation of mitochondrial membrane permeability|phosphatidylinositol-4-phosphate binding|protein localization to plasma membrane|positive regulation of intrinsic apoptotic signaling pathway Pou4f1 3.210159312 1.682644896 0.003783938 Up 0.218835071 0.197546614 0.071013139 0.319454133 0.580377878 0.627346153 "POU domain, class 4, transcription factor 1" "GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001967,GO:0003223,GO:0003677,GO:0003682,GO:0003697,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0007275,GO:0007399,GO:0007498,GO:0007507,GO:0010628,GO:0010629,GO:0021535,GO:0021559,GO:0021953,GO:0021986,GO:0030182,GO:0031175,GO:0043005,GO:0043065,GO:0043066,GO:0043069,GO:0043524,GO:0043565,GO:0045672,GO:0045944,GO:0048665,GO:0048880,GO:0048934,GO:0048935,GO:0050767,GO:0051020,GO:0051090,GO:0051355,GO:0051726,GO:0060384,GO:0061629,GO:0071345,GO:0071392,GO:0072332,GO:0090575,GO:1990837,GO:2000679,GO:2001208" "negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|suckling behavior|ventricular compact myocardium morphogenesis|DNA binding|chromatin binding|single-stranded DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|nervous system development|mesoderm development|heart development|positive regulation of gene expression|negative regulation of gene expression|cell migration in hindbrain|trigeminal nerve development|central nervous system neuron differentiation|habenula development|neuron differentiation|neuron projection development|neuron projection|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of programmed cell death|negative regulation of neuron apoptotic process|sequence-specific DNA binding|positive regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|neuron fate specification|sensory system development|peripheral nervous system neuron differentiation|peripheral nervous system neuron development|regulation of neurogenesis|GTPase binding|regulation of DNA-binding transcription factor activity|proprioception involved in equilibrioception|regulation of cell cycle|innervation|RNA polymerase II-specific DNA-binding transcription factor binding|cellular response to cytokine stimulus|cellular response to estradiol stimulus|intrinsic apoptotic signaling pathway by p53 class mediator|RNA polymerase II transcription regulator complex|sequence-specific double-stranded DNA binding|positive regulation of transcription regulatory region DNA binding|negative regulation of transcription elongation by RNA polymerase I" Ppfibp1 0.829583689 -0.269540566 0.034042589 Down 4.038167973 4.106249569 4.745578148 3.670178991 3.158740984 3.856529774 "PTPRF interacting protein, binding protein 1 (liprin beta 1)" "GO:0007528,GO:0048786,GO:0050808" neuromuscular junction development|presynaptic active zone|synapse organization Ppp1r3g 0.679787431 -0.556844408 0.018217385 Down 2.796465358 2.195075364 3.784421799 1.679668412 2.027213601 2.157925988 "protein phosphatase 1, regulatory subunit 3G" "GO:0000164,GO:0005737,GO:0005979,GO:0008157,GO:0019903,GO:0042593,GO:0045725,GO:2000467,GO:2001069" protein phosphatase type 1 complex|cytoplasm|regulation of glycogen biosynthetic process|protein phosphatase 1 binding|protein phosphatase binding|glucose homeostasis|positive regulation of glycogen biosynthetic process|positive regulation of glycogen (starch) synthase activity|glycogen binding Prdm16 1.256522561 0.329436575 0.038770721 Up 1.642347299 1.561694387 1.502648623 1.972979585 1.83483791 2.102383906 PR domain containing 16 "GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0001228,GO:0003677,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0008168,GO:0016235,GO:0016740,GO:0017053,GO:0019827,GO:0022008,GO:0030154,GO:0030512,GO:0030853,GO:0032259,GO:0035019,GO:0043457,GO:0043565,GO:0043586,GO:0045892,GO:0045893,GO:0046332,GO:0046872,GO:0046974,GO:0048468,GO:0050872,GO:0050873,GO:0060021,GO:0070828,GO:0090336,GO:0120162,GO:0140297" "negative regulation of transcription by RNA polymerase II|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|methyltransferase activity|aggresome|transferase activity|transcription repressor complex|stem cell population maintenance|neurogenesis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of granulocyte differentiation|methylation|somatic stem cell population maintenance|regulation of cellular respiration|sequence-specific DNA binding|tongue development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|SMAD binding|metal ion binding|histone methyltransferase activity (H3-K9 specific)|cell development|white fat cell differentiation|brown fat cell differentiation|roof of mouth development|heterochromatin organization|positive regulation of brown fat cell differentiation|positive regulation of cold-induced thermogenesis|DNA-binding transcription factor binding" "mmu00310,mmu04714" Lysine degradation|Thermogenesis Psmb8 0.525070064 -0.929418149 0.001382061 Down 4.815087296 4.982136095 5.120087997 2.752756026 2.454328145 2.618473421 "proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)" "GO:0000502,GO:0002376,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006508,GO:0008233,GO:0010499,GO:0016787,GO:0019882,GO:0030154,GO:0043161,GO:0045444,GO:0051603,GO:0052548,GO:1990111" proteasome complex|immune system process|endopeptidase activity|threonine-type endopeptidase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|proteolysis|peptidase activity|proteasomal ubiquitin-independent protein catabolic process|hydrolase activity|antigen processing and presentation|cell differentiation|proteasome-mediated ubiquitin-dependent protein catabolic process|fat cell differentiation|proteolysis involved in cellular protein catabolic process|regulation of endopeptidase activity|spermatoproteasome complex mmu03050 Proteasome Psmb9 0.48372092 -1.047753161 0.015905024 Down 2.491171134 2.571576391 2.559927712 1.563886267 1.091161631 1.070256304 "proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)" "GO:0000502,GO:0002376,GO:0004175,GO:0004298,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006508,GO:0008233,GO:0009617,GO:0010499,GO:0016787,GO:0019882,GO:0043161,GO:0051603,GO:0070628,GO:1990111,GO:2000116" proteasome complex|immune system process|endopeptidase activity|threonine-type endopeptidase activity|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|proteolysis|peptidase activity|response to bacterium|proteasomal ubiquitin-independent protein catabolic process|hydrolase activity|antigen processing and presentation|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process|proteasome binding|spermatoproteasome complex|regulation of cysteine-type endopeptidase activity mmu03050 Proteasome Rasgrp3 1.283751498 0.36036596 0.027927393 Up 3.350113298 2.654881984 2.745613373 3.84259578 3.973572915 3.379166961 "RAS, guanyl releasing protein 3" "GO:0005085,GO:0005096,GO:0005737,GO:0007265,GO:0019900,GO:0031267,GO:0032045,GO:0043087,GO:0048471" guanyl-nucleotide exchange factor activity|GTPase activator activity|cytoplasm|Ras protein signal transduction|kinase binding|small GTPase binding|guanyl-nucleotide exchange factor complex|regulation of GTPase activity|perinuclear region of cytoplasm "mmu04010,mmu04014,mmu04015,mmu04662,mmu05200" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|B cell receptor signaling pathway|Pathways in cancer Rasl11b 0.819411169 -0.287340537 0.00263575 Down 41.01226686 35.64336455 36.19163764 30.46715493 30.32143467 31.40574795 "RAS-like, family 11, member B" "GO:0000166,GO:0003924,GO:0005160,GO:0005515,GO:0005525,GO:0007165,GO:0016020,GO:0016787,GO:0030512" nucleotide binding|GTPase activity|transforming growth factor beta receptor binding|protein binding|GTP binding|signal transduction|membrane|hydrolase activity|negative regulation of transforming growth factor beta receptor signaling pathway Rem2 0.772626517 -0.372156903 0.041307667 Down 6.574107378 7.833574724 7.313863614 4.911515492 5.810803767 6.055693091 rad and gem related GTP binding protein 2 "GO:0000166,GO:0003924,GO:0005246,GO:0005525,GO:0005886,GO:0007165,GO:0016020" nucleotide binding|GTPase activity|calcium channel regulator activity|GTP binding|plasma membrane|signal transduction|membrane Resp18 1.206562185 0.270902272 0.00127346 Up 88.2132925 106.7856987 84.19317809 106.1186874 124.5594211 105.0247164 regulated endocrine-specific protein 18 "GO:0001701,GO:0005783,GO:0005794,GO:0030141,GO:0031410,GO:0043204,GO:0048237" in utero embryonic development|endoplasmic reticulum|Golgi apparatus|secretory granule|cytoplasmic vesicle|perikaryon|rough endoplasmic reticulum lumen Ret 1.371150843 0.455387294 0.011253841 Up 2.790214229 2.243288323 1.964048733 2.622648368 3.350008319 3.595411585 ret proto-oncogene "GO:0000165,GO:0000166,GO:0000187,GO:0001657,GO:0001755,GO:0001838,GO:0004672,GO:0004713,GO:0004714,GO:0005509,GO:0005515,GO:0005524,GO:0005768,GO:0005769,GO:0005886,GO:0005887,GO:0006468,GO:0006919,GO:0007155,GO:0007156,GO:0007158,GO:0007169,GO:0007275,GO:0007399,GO:0009653,GO:0010008,GO:0010628,GO:0010976,GO:0014042,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0030155,GO:0030182,GO:0030335,GO:0030424,GO:0030425,GO:0033139,GO:0033141,GO:0033619,GO:0033630,GO:0033674,GO:0035799,GO:0035860,GO:0042551,GO:0043025,GO:0043235,GO:0043410,GO:0045121,GO:0045793,GO:0045893,GO:0048265,GO:0048484,GO:0050770,GO:0051897,GO:0060384,GO:0061146,GO:0071300,GO:0072300,GO:0098797,GO:2001241" "MAPK cascade|nucleotide binding|activation of MAPK activity|ureteric bud development|neural crest cell migration|embryonic epithelial tube formation|protein kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|calcium ion binding|protein binding|ATP binding|endosome|early endosome|plasma membrane|integral component of plasma membrane|protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|neuron cell-cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|nervous system development|anatomical structure morphogenesis|endosome membrane|positive regulation of gene expression|positive regulation of neuron projection development|positive regulation of neuron maturation|membrane|integral component of membrane|kinase activity|phosphorylation|transferase activity|regulation of cell adhesion|neuron differentiation|positive regulation of cell migration|axon|dendrite|regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of peptidyl-serine phosphorylation of STAT protein|membrane protein proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of kinase activity|ureter maturation|glial cell-derived neurotrophic factor receptor signaling pathway|neuron maturation|neuronal cell body|receptor complex|positive regulation of MAPK cascade|membrane raft|positive regulation of cell size|positive regulation of transcription, DNA-templated|response to pain|enteric nervous system development|regulation of axonogenesis|positive regulation of protein kinase B signaling|innervation|Peyer's patch morphogenesis|cellular response to retinoic acid|positive regulation of metanephric glomerulus development|plasma membrane protein complex|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand" "mmu04020,mmu05200,mmu05216,mmu05223,mmu05230" Calcium signaling pathway|Pathways in cancer|Thyroid cancer|Non-small cell lung cancer|Central carbon metabolism in cancer Rnf213 0.335664775 -1.574906949 1.67E-06 Down 2.011237888 1.606003581 3.437550677 0.777034775 0.729635807 0.736357693 ring finger protein 213 "GO:0001525,GO:0002040,GO:0004842,GO:0005730,GO:0005737,GO:0005829,GO:0006511,GO:0016567,GO:0016740,GO:0016787,GO:0016887,GO:0046872,GO:0051260,GO:0051865,GO:0140603,GO:2000051" angiogenesis|sprouting angiogenesis|ubiquitin-protein transferase activity|nucleolus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|transferase activity|hydrolase activity|ATPase|metal ion binding|protein homooligomerization|protein autoubiquitination|ATP hydrolysis activity|negative regulation of non-canonical Wnt signaling pathway Rsad2 0.280340526 -1.83474778 1.90E-06 Down 1.095852031 0.739645054 3.044634412 0.430834046 0.30608428 0.436683751 radical S-adenosyl methionine domain containing 2 "GO:0001503,GO:0001650,GO:0002376,GO:0003824,GO:0005515,GO:0005739,GO:0005741,GO:0005743,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0009615,GO:0016020,GO:0016829,GO:0030278,GO:0034157,GO:0034165,GO:0035710,GO:0043367,GO:0043621,GO:0045071,GO:0045087,GO:0046872,GO:0050709,GO:0050778,GO:0051536,GO:0051539,GO:0051607,GO:2000553" "ossification|fibrillar center|immune system process|catalytic activity|protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|response to virus|membrane|lyase activity|regulation of ossification|positive regulation of toll-like receptor 7 signaling pathway|positive regulation of toll-like receptor 9 signaling pathway|CD4-positive, alpha-beta T cell activation|CD4-positive, alpha-beta T cell differentiation|protein self-association|negative regulation of viral genome replication|innate immune response|metal ion binding|negative regulation of protein secretion|positive regulation of immune response|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding|defense response to virus|positive regulation of T-helper 2 cell cytokine production" "mmu05160,mmu05164" Hepatitis C|Influenza A Rsph3b 1.420166387 0.506059967 0.02709442 Up 4.251420378 4.693476212 4.010130462 4.921388181 6.166553486 7.488507419 radial spoke 3B homolog (Chlamydomonas) "GO:0005737,GO:0005856,GO:0005929,GO:0042995" cytoplasm|cytoskeleton|cilium|cell projection Rsph4a 1.40951433 0.495198145 0.044889808 Up 1.360854368 1.684396085 1.398414088 2.104137887 2.45267659 1.726433695 radial spoke head 4 homolog A (Chlamydomonas) "GO:0001534,GO:0001535,GO:0003341,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005856,GO:0005929,GO:0005930,GO:0030030,GO:0035082,GO:0042995,GO:0060271,GO:0060294,GO:0062177,GO:0120221" radial spoke|radial spoke head|cilium movement|protein binding|nucleoplasm|nucleolus|cytoplasm|cytoskeleton|cilium|axoneme|cell projection organization|axoneme assembly|cell projection|cilium assembly|cilium movement involved in cell motility|radial spoke assembly|maintenance of ciliary planar beating movement pattern Rspo2 1.353227572 0.436404477 0.006551511 Up 1.367967175 1.482314039 1.202730688 1.750235247 1.889253756 1.823169926 R-spondin 2 "GO:0001649,GO:0005102,GO:0005576,GO:0007275,GO:0008201,GO:0009986,GO:0016055,GO:0030177,GO:0030282,GO:0035115,GO:0035116,GO:0042489,GO:0050896,GO:0060173,GO:0060437,GO:0060441,GO:0060535,GO:0071542,GO:0090263" osteoblast differentiation|signaling receptor binding|extracellular region|multicellular organism development|heparin binding|cell surface|Wnt signaling pathway|positive regulation of Wnt signaling pathway|bone mineralization|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|negative regulation of odontogenesis of dentin-containing tooth|response to stimulus|limb development|lung growth|epithelial tube branching involved in lung morphogenesis|trachea cartilage morphogenesis|dopaminergic neuron differentiation|positive regulation of canonical Wnt signaling pathway mmu04310 Wnt signaling pathway Rsrp1 0.814374446 -0.296235802 0.000237515 Down 67.96290436 82.24291332 88.06070924 54.53657739 62.03880002 78.11604931 arginine/serine rich protein 1 Rtp4 0.21333858 -2.22878321 7.98E-21 Down 3.721013589 3.970208998 5.699835274 0.768063915 0.876183378 1.210170965 receptor transporter protein 4 "GO:0001580,GO:0005515,GO:0005737,GO:0006612,GO:0016020,GO:0016021,GO:0031849,GO:0051205,GO:0051607" detection of chemical stimulus involved in sensory perception of bitter taste|protein binding|cytoplasm|protein targeting to membrane|membrane|integral component of membrane|olfactory receptor binding|protein insertion into membrane|defense response to virus S100a5 0.078593875 -3.669439297 0.00859943 Down 7.04573654 2.83233064 0.452512474 3.295793374 0.064693377 0 S100 calcium binding protein A5 "GO:0005507,GO:0005509,GO:0005634,GO:0008270,GO:0042803,GO:0043025,GO:0046872,GO:0046914,GO:0048306" copper ion binding|calcium ion binding|nucleus|zinc ion binding|protein homodimerization activity|neuronal cell body|metal ion binding|transition metal ion binding|calcium-dependent protein binding Sall3 0.680880107 -0.554527312 0.031125039 Down 1.411951156 1.088535005 0.596268967 0.69045129 0.601691171 0.71209811 spalt like transcription factor 3 "GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0021891,GO:0035136,GO:0035137,GO:0045879,GO:0046872" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|olfactory bulb interneuron development|forelimb morphogenesis|hindlimb morphogenesis|negative regulation of smoothened signaling pathway|metal ion binding" Samd9l 0.603623333 -0.728279522 0.001903598 Down 1.721571866 1.634862459 2.403651393 1.355213969 0.991051003 1.104188834 sterile alpha motif domain containing 9-like "GO:0002244,GO:0005515,GO:0005737,GO:0005769,GO:0017145,GO:0034058,GO:0035726,GO:0042176,GO:0048536" hematopoietic progenitor cell differentiation|protein binding|cytoplasm|early endosome|stem cell division|endosomal vesicle fusion|common myeloid progenitor cell proliferation|regulation of protein catabolic process|spleen development Samhd1 0.748392303 -0.418133373 0.00912162 Down 4.142255187 3.624587154 4.72581135 2.914968092 3.119374554 3.267971755 "SAM domain and HD domain, 1" "GO:0000166,GO:0000724,GO:0002376,GO:0003676,GO:0003697,GO:0003723,GO:0003824,GO:0005525,GO:0005634,GO:0005654,GO:0005694,GO:0005886,GO:0006203,GO:0006260,GO:0006281,GO:0006974,GO:0008152,GO:0008270,GO:0008832,GO:0009264,GO:0016446,GO:0016787,GO:0016793,GO:0032567,GO:0035861,GO:0042802,GO:0045087,GO:0045088,GO:0046061,GO:0046872,GO:0051289,GO:0051607,GO:0060339,GO:0097197,GO:0110025" nucleotide binding|double-strand break repair via homologous recombination|immune system process|nucleic acid binding|single-stranded DNA binding|RNA binding|catalytic activity|GTP binding|nucleus|nucleoplasm|chromosome|plasma membrane|dGTP catabolic process|DNA replication|DNA repair|cellular response to DNA damage stimulus|metabolic process|zinc ion binding|dGTPase activity|deoxyribonucleotide catabolic process|somatic hypermutation of immunoglobulin genes|hydrolase activity|triphosphoric monoester hydrolase activity|dGTP binding|site of double-strand break|identical protein binding|innate immune response|regulation of innate immune response|dATP catabolic process|metal ion binding|protein homotetramerization|defense response to virus|negative regulation of type I interferon-mediated signaling pathway|tetraspanin-enriched microdomain|DNA strand resection involved in replication fork processing mmu05170 Human immunodeficiency virus 1 infection Scara3 0.797558963 -0.326336914 0.007476707 Down 8.15973242 7.571902624 8.698506178 6.698783717 6.601437296 6.144373966 "scavenger receptor class A, member 3" "GO:0005201,GO:0005581,GO:0005615,GO:0005783,GO:0005794,GO:0016020,GO:0016021,GO:0030198,GO:0031012" extracellular matrix structural constituent|collagen trimer|extracellular space|endoplasmic reticulum|Golgi apparatus|membrane|integral component of membrane|extracellular matrix organization|extracellular matrix Scrt2 0.816414649 -0.292626026 0.028649391 Down 8.144918876 8.01975245 8.369719471 6.027316923 6.51468979 7.53092561 scratch family zinc finger 2 "GO:0000122,GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0006355,GO:0046872,GO:1990837,GO:2001222" "negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription, DNA-templated|metal ion binding|sequence-specific double-stranded DNA binding|regulation of neuron migration" Sema4d 0.814622473 -0.29579648 0.000495562 Down 15.18917085 13.50829661 13.70887385 11.47417742 11.6726529 11.31413807 "sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D" "GO:0000122,GO:0001755,GO:0001934,GO:0004888,GO:0005102,GO:0005515,GO:0005615,GO:0005886,GO:0005887,GO:0007162,GO:0007275,GO:0007399,GO:0007411,GO:0008360,GO:0010693,GO:0014068,GO:0016020,GO:0016021,GO:0030154,GO:0030215,GO:0030335,GO:0031344,GO:0038023,GO:0042802,GO:0043547,GO:0043931,GO:0045499,GO:0045668,GO:0048672,GO:0048814,GO:0048843,GO:0050731,GO:0050732,GO:0050772,GO:0050919,GO:0070486,GO:0071526,GO:1900220,GO:1905704" negative regulation of transcription by RNA polymerase II|neural crest cell migration|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|signaling receptor binding|protein binding|extracellular space|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|multicellular organism development|nervous system development|axon guidance|regulation of cell shape|negative regulation of alkaline phosphatase activity|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|integral component of membrane|cell differentiation|semaphorin receptor binding|positive regulation of cell migration|regulation of cell projection organization|signaling receptor activity|identical protein binding|positive regulation of GTPase activity|ossification involved in bone maturation|chemorepellent activity|negative regulation of osteoblast differentiation|positive regulation of collateral sprouting|regulation of dendrite morphogenesis|negative regulation of axon extension involved in axon guidance|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of peptidyl-tyrosine phosphorylation|positive regulation of axonogenesis|negative chemotaxis|leukocyte aggregation|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|positive regulation of inhibitory synapse assembly mmu04360 Axon guidance Serpina3f 0.048209058 -4.374551958 0.041367185 Down 0.134167878 0.167796007 0.022978487 0 0 0 "serine (or cysteine) peptidase inhibitor, clade A, member 3F" "GO:0004867,GO:0005615,GO:0009617,GO:0010466,GO:0010951,GO:0030414,GO:0034097,GO:0043434" serine-type endopeptidase inhibitor activity|extracellular space|response to bacterium|negative regulation of peptidase activity|negative regulation of endopeptidase activity|peptidase inhibitor activity|response to cytokine|response to peptide hormone Sfrp5 1.674572163 0.743792548 0.003498176 Up 2.479516532 2.715772071 2.049439204 3.654555278 4.711720817 3.751529992 secreted frizzled-related sequence protein 5 "GO:0005576,GO:0005615,GO:0007275,GO:0008285,GO:0016055,GO:0017147,GO:0030111,GO:0030154,GO:0030178,GO:0030510,GO:0035567,GO:0036342,GO:0043433,GO:0043508,GO:0048546,GO:0051898,GO:0060028,GO:0060070,GO:0090090,GO:0090175,GO:0090179,GO:2000041,GO:2000057" extracellular region|extracellular space|multicellular organism development|negative regulation of cell population proliferation|Wnt signaling pathway|Wnt-protein binding|regulation of Wnt signaling pathway|cell differentiation|negative regulation of Wnt signaling pathway|regulation of BMP signaling pathway|non-canonical Wnt signaling pathway|post-anal tail morphogenesis|negative regulation of DNA-binding transcription factor activity|negative regulation of JUN kinase activity|digestive tract morphogenesis|negative regulation of protein kinase B signaling|convergent extension involved in axis elongation|canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of establishment of planar polarity|planar cell polarity pathway involved in neural tube closure|negative regulation of planar cell polarity pathway involved in axis elongation|negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis mmu04310 Wnt signaling pathway Shisa3 0.49742967 -1.007435532 0.00934248 Down 1.909706161 1.242921563 0.336413871 1.163049045 0.350695319 0.247663026 shisa family member 3 "GO:0005783,GO:0007275,GO:0016020,GO:0016021,GO:0090090" endoplasmic reticulum|multicellular organism development|membrane|integral component of membrane|negative regulation of canonical Wnt signaling pathway Shisa5 0.832983296 -0.26364053 0.00841226 Down 27.7803045 24.64261423 25.13317047 20.24114746 23.2279135 21.06888176 shisa family member 5 "GO:0005634,GO:0005635,GO:0005783,GO:0006915,GO:0016020,GO:0016021,GO:0042771,GO:0050699,GO:0072332" nucleus|nuclear envelope|endoplasmic reticulum|apoptotic process|membrane|integral component of membrane|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|WW domain binding|intrinsic apoptotic signaling pathway by p53 class mediator mmu04115 p53 signaling pathway Shisa8 0.454740812 -1.136883606 2.13E-06 Down 7.057057179 4.08469248 1.897862547 2.716047387 1.659382672 1.196181281 shisa family member 8 "GO:0014069,GO:0016020,GO:0016021,GO:0032281,GO:0032591,GO:0045211,GO:0048172,GO:2000311" postsynaptic density|membrane|integral component of membrane|AMPA glutamate receptor complex|dendritic spine membrane|postsynaptic membrane|regulation of short-term neuronal synaptic plasticity|regulation of AMPA receptor activity Shox2 1.495758517 0.580877278 0.002054972 Up 1.971411228 1.806881301 1.671303463 2.652955373 2.615281147 2.863451775 short stature homeobox 2 "GO:0000122,GO:0000981,GO:0001649,GO:0002027,GO:0002053,GO:0002062,GO:0002063,GO:0003163,GO:0003170,GO:0003209,GO:0003213,GO:0003677,GO:0005634,GO:0006355,GO:0006357,GO:0007275,GO:0030326,GO:0032330,GO:0035115,GO:0043565,GO:0045880,GO:0045944,GO:0048557,GO:0048598,GO:0048743,GO:0050772,GO:0060272,GO:0060351,GO:0060415,GO:0060920,GO:0060931,GO:1990837,GO:2000172" "negative regulation of transcription by RNA polymerase II|DNA-binding transcription factor activity, RNA polymerase II-specific|osteoblast differentiation|regulation of heart rate|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|chondrocyte development|sinoatrial node development|heart valve development|cardiac atrium morphogenesis|cardiac right atrium morphogenesis|DNA binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|multicellular organism development|embryonic limb morphogenesis|regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|sequence-specific DNA binding|positive regulation of smoothened signaling pathway|positive regulation of transcription by RNA polymerase II|embryonic digestive tract morphogenesis|embryonic morphogenesis|positive regulation of skeletal muscle fiber development|positive regulation of axonogenesis|embryonic skeletal joint morphogenesis|cartilage development involved in endochondral bone morphogenesis|muscle tissue morphogenesis|cardiac pacemaker cell differentiation|sinoatrial node cell development|sequence-specific double-stranded DNA binding|regulation of branching morphogenesis of a nerve" Sik1 0.705869442 -0.502526729 0.002583298 Down 4.138200669 4.763314914 3.973568518 2.892086188 2.825453614 3.352956716 salt inducible kinase 1 "GO:0000122,GO:0000166,GO:0000287,GO:0002028,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0007049,GO:0007275,GO:0007346,GO:0008140,GO:0010830,GO:0010868,GO:0016301,GO:0016310,GO:0016740,GO:0019901,GO:0030154,GO:0032792,GO:0035556,GO:0042149,GO:0042826,GO:0043153,GO:0043276,GO:0045595,GO:0045721,GO:0046872,GO:0048511,GO:0055007,GO:0106310,GO:0106311" negative regulation of transcription by RNA polymerase II|nucleotide binding|magnesium ion binding|regulation of sodium ion transport|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|cell cycle|multicellular organism development|regulation of mitotic cell cycle|cAMP response element binding protein binding|regulation of myotube differentiation|negative regulation of triglyceride biosynthetic process|kinase activity|phosphorylation|transferase activity|protein kinase binding|cell differentiation|negative regulation of CREB transcription factor activity|intracellular signal transduction|cellular response to glucose starvation|histone deacetylase binding|entrainment of circadian clock by photoperiod|anoikis|regulation of cell differentiation|negative regulation of gluconeogenesis|metal ion binding|rhythmic process|cardiac muscle cell differentiation|protein serine kinase activity|protein threonine kinase activity mmu04922 Glucagon signaling pathway Slc17a6 1.410845562 0.496560073 2.63E-08 Up 15.81405205 18.78699988 16.20362245 25.58674804 24.21815607 21.72861671 "solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6" "GO:0001504,GO:0005313,GO:0005326,GO:0005769,GO:0006811,GO:0006814,GO:0006820,GO:0006836,GO:0008021,GO:0015293,GO:0016020,GO:0016021,GO:0022857,GO:0030054,GO:0030285,GO:0031410,GO:0035249,GO:0043005,GO:0045202,GO:0050803,GO:0055085,GO:0060076,GO:0098700,GO:0098793,GO:1990030,GO:1990384" "neurotransmitter uptake|L-glutamate transmembrane transporter activity|neurotransmitter transmembrane transporter activity|early endosome|ion transport|sodium ion transport|anion transport|neurotransmitter transport|synaptic vesicle|symporter activity|membrane|integral component of membrane|transmembrane transporter activity|cell junction|integral component of synaptic vesicle membrane|cytoplasmic vesicle|synaptic transmission, glutamatergic|neuron projection|synapse|regulation of synapse structure or activity|transmembrane transport|excitatory synapse|neurotransmitter loading into synaptic vesicle|presynapse|pericellular basket|hyaloid vascular plexus regression" "mmu04721,mmu04723,mmu04724,mmu05033" Synaptic vesicle cycle|Retrograde endocannabinoid signaling|Glutamatergic synapse|Nicotine addiction Slc18a2 1.568130204 0.649045354 0.005634205 Up 1.885100428 1.587762077 1.895619478 2.060981759 3.157132075 3.327535491 "solute carrier family 18 (vesicular monoamine), member 2" "GO:0001975,GO:0005275,GO:0005335,GO:0005515,GO:0005737,GO:0005813,GO:0006836,GO:0007568,GO:0007626,GO:0008021,GO:0009636,GO:0009791,GO:0015842,GO:0015844,GO:0016020,GO:0016021,GO:0019899,GO:0022857,GO:0030073,GO:0030285,GO:0030672,GO:0031045,GO:0031072,GO:0031410,GO:0035690,GO:0042593,GO:0042908,GO:0042910,GO:0042995,GO:0043005,GO:0043025,GO:0043195,GO:0043231,GO:0043679,GO:0044297,GO:0051589,GO:0051610,GO:0055085,GO:0098691,GO:0098700,GO:0098794,GO:0098992,GO:0099066" response to amphetamine|amine transmembrane transporter activity|serotonin:sodium symporter activity|protein binding|cytoplasm|centrosome|neurotransmitter transport|aging|locomotory behavior|synaptic vesicle|response to toxic substance|post-embryonic development|aminergic neurotransmitter loading into synaptic vesicle|monoamine transport|membrane|integral component of membrane|enzyme binding|transmembrane transporter activity|insulin secretion|integral component of synaptic vesicle membrane|synaptic vesicle membrane|dense core granule|heat shock protein binding|cytoplasmic vesicle|cellular response to drug|glucose homeostasis|xenobiotic transport|xenobiotic transmembrane transporter activity|cell projection|neuron projection|neuronal cell body|terminal bouton|intracellular membrane-bounded organelle|axon terminus|cell body|negative regulation of neurotransmitter transport|serotonin uptake|transmembrane transport|dopaminergic synapse|neurotransmitter loading into synaptic vesicle|postsynapse|neuronal dense core vesicle|integral component of neuronal dense core vesicle membrane "mmu04721,mmu04726,mmu04728,mmu05012,mmu05030,mmu05031,mmu05034" Synaptic vesicle cycle|Serotonergic synapse|Dopaminergic synapse|Parkinson disease|Cocaine addiction|Amphetamine addiction|Alcoholism Slc2a1 0.747560386 -0.419737975 1.66E-05 Down 47.03194426 41.50668566 55.60039295 35.44626395 37.07499548 34.41483477 "solute carrier family 2 (facilitated glucose transporter), member 1" "GO:0001917,GO:0001939,GO:0005324,GO:0005355,GO:0005515,GO:0005622,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005901,GO:0005911,GO:0007417,GO:0008643,GO:0014704,GO:0015911,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019900,GO:0022857,GO:0030018,GO:0030496,GO:0030864,GO:0031982,GO:0033300,GO:0042149,GO:0042383,GO:0042802,GO:0042908,GO:0042910,GO:0043621,GO:0045121,GO:0045202,GO:0055056,GO:0055085,GO:0065003,GO:0070837,GO:0098708,GO:0098793,GO:0150104,GO:1904659" photoreceptor inner segment|female pronucleus|long-chain fatty acid transporter activity|glucose transmembrane transporter activity|protein binding|intracellular anatomical structure|cytoplasm|cytosol|plasma membrane|integral component of plasma membrane|caveola|cell-cell junction|central nervous system development|carbohydrate transport|intercalated disc|long-chain fatty acid import across plasma membrane|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|kinase binding|transmembrane transporter activity|Z disc|midbody|cortical actin cytoskeleton|vesicle|dehydroascorbic acid transmembrane transporter activity|cellular response to glucose starvation|sarcolemma|identical protein binding|xenobiotic transport|xenobiotic transmembrane transporter activity|protein self-association|membrane raft|synapse|D-glucose transmembrane transporter activity|transmembrane transport|protein-containing complex assembly|dehydroascorbic acid transport|glucose import across plasma membrane|presynapse|transport across blood-brain barrier|glucose transmembrane transport "mmu04066,mmu04911,mmu04919,mmu04920,mmu04922,mmu04931,mmu04976,mmu05166,mmu05200,mmu05211,mmu05230,mmu05415" HIF-1 signaling pathway|Insulin secretion|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Bile secretion|Human T-cell leukemia virus 1 infection|Pathways in cancer|Renal cell carcinoma|Central carbon metabolism in cancer|Diabetic cardiomyopathy Slc7a11 1.285019012 0.361789704 0.000766886 Up 4.853132885 5.461109812 4.226338855 6.190960425 6.079237636 6.300177595 "solute carrier family 7 (cationic amino acid transporter, y+ system), member 11" "GO:0003333,GO:0005791,GO:0005856,GO:0005886,GO:0006749,GO:0006865,GO:0007420,GO:0008542,GO:0009636,GO:0009986,GO:0014070,GO:0015179,GO:0016020,GO:0016021,GO:0021591,GO:0021756,GO:0022857,GO:0030534,GO:0031526,GO:0033029,GO:0033554,GO:0034599,GO:0034775,GO:0042127,GO:0043231,GO:0045177,GO:0048021,GO:0048286,GO:0050804,GO:0050807,GO:0051223,GO:0051775,GO:0055085,GO:0060173,GO:0070527,GO:0071702,GO:0090461,GO:0097449,GO:0098712,GO:0140206,GO:1900407,GO:1901494,GO:1903204,GO:1903786,GO:1904717,GO:2000211" amino acid transmembrane transport|rough endoplasmic reticulum|cytoskeleton|plasma membrane|glutathione metabolic process|amino acid transport|brain development|visual learning|response to toxic substance|cell surface|response to organic cyclic compound|L-amino acid transmembrane transporter activity|membrane|integral component of membrane|ventricular system development|striatum development|transmembrane transporter activity|adult behavior|brush border membrane|regulation of neutrophil apoptotic process|cellular response to stress|cellular response to oxidative stress|glutathione transmembrane transport|regulation of cell population proliferation|intracellular membrane-bounded organelle|apical part of cell|regulation of melanin biosynthetic process|lung alveolus development|modulation of chemical synaptic transmission|regulation of synapse organization|regulation of protein transport|response to redox state|transmembrane transport|limb development|platelet aggregation|organic substance transport|glutamate homeostasis|astrocyte projection|L-glutamate import across plasma membrane|dipeptide import across plasma membrane|regulation of cellular response to oxidative stress|regulation of cysteine metabolic process|negative regulation of oxidative stress-induced neuron death|regulation of glutathione biosynthetic process|regulation of AMPA glutamate receptor clustering|regulation of glutamate metabolic process mmu04216 Ferroptosis Slfn2 0.269013209 -1.894251083 1.07E-06 Down 2.861952414 2.342200621 4.458848449 0.695478268 1.107640817 0.744973556 schlafen 2 "GO:0008285,GO:0009617" negative regulation of cell population proliferation|response to bacterium Slfn3 0.275249319 -1.861189099 0.029174079 Down 0.338374934 0.362730828 0.869285291 0.202766592 0.057996045 0.170654735 schlafen 3 GO:0008285 negative regulation of cell population proliferation Slfn5 0.438836505 -1.188244554 0.003783433 Down 2.080880597 1.685964203 3.804208216 0.836816533 1.269025452 1.065734208 schlafen 5 "GO:0000166,GO:0005524,GO:0005634,GO:0030154" nucleotide binding|ATP binding|nucleus|cell differentiation Slfn8 0.285447161 -1.808704382 9.30E-06 Down 0.797460251 0.75676189 1.571770781 0.214872391 0.2823254 0.369221853 schlafen 8 "GO:0000049,GO:0000166,GO:0002376,GO:0004518,GO:0004519,GO:0004521,GO:0005524,GO:0005737,GO:0008270,GO:0016075,GO:0016078,GO:0016787,GO:0046872,GO:0051607" tRNA binding|nucleotide binding|immune system process|nuclease activity|endonuclease activity|endoribonuclease activity|ATP binding|cytoplasm|zinc ion binding|rRNA catabolic process|tRNA catabolic process|hydrolase activity|metal ion binding|defense response to virus Smim3 0.653828393 -0.613016066 0.006133374 Down 3.889711189 3.780212341 5.863829964 2.744336768 2.945114701 2.99647683 small integral membrane protein 3 "GO:0016020,GO:0016021,GO:0042802" membrane|integral component of membrane|identical protein binding Smox 0.820037363 -0.286238451 0.020760556 Down 8.111744441 6.599663637 9.024730256 5.884481548 6.896203784 6.560343549 spermine oxidase "GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006598,GO:0016491,GO:0031965,GO:0043231,GO:0046208,GO:0046592,GO:0052894,GO:0052895,GO:0052901" nucleus|nucleoplasm|cytoplasm|cytosol|polyamine catabolic process|oxidoreductase activity|nuclear membrane|intracellular membrane-bounded organelle|spermine catabolic process|polyamine oxidase activity|norspermine:oxygen oxidoreductase activity|N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity|spermine:oxygen oxidoreductase (spermidine-forming) activity "mmu00330,mmu00410" Arginine and proline metabolism|beta-Alanine metabolism Sncg 1.682548107 0.750647754 0.005224913 Up 6.645769987 6.149245562 4.672606366 9.054691727 12.22987644 8.185210365 "synuclein, gamma" "GO:0005515,GO:0005737,GO:0005813,GO:0005856,GO:0005886,GO:0007268,GO:0008344,GO:0009306,GO:0014059,GO:0030424,GO:0043014,GO:0043025,GO:0043679,GO:0046928,GO:0048471,GO:0048487,GO:0048488,GO:0050808,GO:1901214,GO:1901215,GO:1903136" protein binding|cytoplasm|centrosome|cytoskeleton|plasma membrane|chemical synaptic transmission|adult locomotory behavior|protein secretion|regulation of dopamine secretion|axon|alpha-tubulin binding|neuronal cell body|axon terminus|regulation of neurotransmitter secretion|perinuclear region of cytoplasm|beta-tubulin binding|synaptic vesicle endocytosis|synapse organization|regulation of neuron death|negative regulation of neuron death|cuprous ion binding Sox9 1.209139383 0.27398056 0.022431493 Up 8.003473107 7.268789828 6.384040126 8.691114645 9.221287273 8.172547981 SRY (sex determining region Y)-box 9 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0001501,GO:0001502,GO:0001503,GO:0001658,GO:0001708,GO:0001837,GO:0001894,GO:0001934,GO:0001942,GO:0002009,GO:0002053,GO:0002062,GO:0002063,GO:0002683,GO:0003170,GO:0003179,GO:0003180,GO:0003188,GO:0003203,GO:0003413,GO:0003415,GO:0003430,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006334,GO:0006338,GO:0006355,GO:0006357,GO:0007010,GO:0007165,GO:0007173,GO:0007219,GO:0007283,GO:0007417,GO:0007507,GO:0008013,GO:0008284,GO:0008285,GO:0008584,GO:0010468,GO:0010564,GO:0010628,GO:0010629,GO:0010634,GO:0014032,GO:0014068,GO:0019100,GO:0019933,GO:0030154,GO:0030155,GO:0030198,GO:0030238,GO:0030279,GO:0030502,GO:0030850,GO:0030857,GO:0030858,GO:0030879,GO:0030903,GO:0030916,GO:0031018,GO:0032331,GO:0032332,GO:0032808,GO:0032991,GO:0034236,GO:0034504,GO:0035019,GO:0035622,GO:0042127,GO:0043066,GO:0043425,GO:0043491,GO:0043565,GO:0045165,GO:0045595,GO:0045662,GO:0045668,GO:0045732,GO:0045892,GO:0045893,GO:0045944,GO:0046322,GO:0046533,GO:0048709,GO:0048873,GO:0050679,GO:0050680,GO:0051216,GO:0060008,GO:0060009,GO:0060018,GO:0060041,GO:0060174,GO:0060221,GO:0060350,GO:0060441,GO:0060487,GO:0060512,GO:0060517,GO:0060532,GO:0060534,GO:0060729,GO:0060784,GO:0061036,GO:0061046,GO:0061138,GO:0061145,GO:0065003,GO:0070168,GO:0070371,GO:0070384,GO:0070542,GO:0071260,GO:0071300,GO:0071364,GO:0071504,GO:0071560,GO:0071599,GO:0072034,GO:0072170,GO:0072189,GO:0072190,GO:0072193,GO:0072197,GO:0072289,GO:0090090,GO:0090103,GO:0090184,GO:0090190,GO:0097065,GO:0097157,GO:0098609,GO:1901203,GO:1902732,GO:1902894,GO:1904864,GO:1990837,GO:2000020,GO:2000138,GO:2000741,GO:2000794,GO:2001054" "negative regulation of transcription by RNA polymerase II|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|cartilage condensation|ossification|branching involved in ureteric bud morphogenesis|cell fate specification|epithelial to mesenchymal transition|tissue homeostasis|positive regulation of protein phosphorylation|hair follicle development|morphogenesis of an epithelium|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|chondrocyte development|negative regulation of immune system process|heart valve development|heart valve morphogenesis|aortic valve morphogenesis|heart valve formation|endocardial cushion morphogenesis|chondrocyte differentiation involved in endochondral bone morphogenesis|chondrocyte hypertrophy|growth plate cartilage chondrocyte growth|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleosome assembly|chromatin remodeling|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|cytoskeleton organization|signal transduction|epidermal growth factor receptor signaling pathway|Notch signaling pathway|spermatogenesis|central nervous system development|heart development|beta-catenin binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|male gonad development|regulation of gene expression|regulation of cell cycle process|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial cell migration|neural crest cell development|positive regulation of phosphatidylinositol 3-kinase signaling|male germ-line sex determination|cAMP-mediated signaling|cell differentiation|regulation of cell adhesion|extracellular matrix organization|male sex determination|negative regulation of ossification|negative regulation of bone mineralization|prostate gland development|negative regulation of epithelial cell differentiation|positive regulation of epithelial cell differentiation|mammary gland development|notochord development|otic vesicle formation|endocrine pancreas development|negative regulation of chondrocyte differentiation|positive regulation of chondrocyte differentiation|lacrimal gland development|protein-containing complex|protein kinase A catalytic subunit binding|protein localization to nucleus|somatic stem cell population maintenance|intrahepatic bile duct development|regulation of cell population proliferation|negative regulation of apoptotic process|bHLH transcription factor binding|protein kinase B signaling|sequence-specific DNA binding|cell fate commitment|regulation of cell differentiation|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of fatty acid oxidation|negative regulation of photoreceptor cell differentiation|oligodendrocyte differentiation|homeostasis of number of cells within a tissue|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|cartilage development|Sertoli cell differentiation|Sertoli cell development|astrocyte fate commitment|retina development in camera-type eye|limb bud formation|retinal rod cell differentiation|endochondral bone morphogenesis|epithelial tube branching involved in lung morphogenesis|lung epithelial cell differentiation|prostate gland morphogenesis|epithelial cell proliferation involved in prostatic bud elongation|bronchus cartilage development|trachea cartilage development|intestinal epithelial structure maintenance|regulation of cell proliferation involved in tissue homeostasis|positive regulation of cartilage development|regulation of branching involved in lung morphogenesis|morphogenesis of a branching epithelium|lung smooth muscle development|protein-containing complex assembly|negative regulation of biomineral tissue development|ERK1 and ERK2 cascade|Harderian gland development|response to fatty acid|cellular response to mechanical stimulus|cellular response to retinoic acid|cellular response to epidermal growth factor stimulus|cellular response to heparin|cellular response to transforming growth factor beta stimulus|otic vesicle development|renal vesicle induction|metanephric tubule development|ureter development|ureter urothelium development|ureter smooth muscle cell differentiation|ureter morphogenesis|metanephric nephron tubule formation|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|positive regulation of kidney development|positive regulation of branching involved in ureteric bud morphogenesis|anterior head development|pre-mRNA intronic binding|cell-cell adhesion|positive regulation of extracellular matrix assembly|positive regulation of chondrocyte proliferation|negative regulation of pri-miRNA transcription by RNA polymerase II|negative regulation of beta-catenin-TCF complex assembly|sequence-specific double-stranded DNA binding|positive regulation of male gonad development|positive regulation of cell proliferation involved in heart morphogenesis|positive regulation of mesenchymal stem cell differentiation|regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell apoptotic process" mmu04024 cAMP signaling pathway Sp100 0.47092838 -1.086420426 0.000328469 Down 1.190141561 1.264615489 2.006132047 0.73998733 0.719316496 0.58970112 nuclear antigen Sp100 "GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0016605" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|PML body" "mmu05168,mmu05203" Herpes simplex virus 1 infection|Viral carcinogenesis Sp7 0.564825558 -0.824122723 0.008889072 Down 2.326899539 1.841494108 0.994963602 1.235274606 0.786935056 0.803362761 Sp7 transcription factor 7 "GO:0000978,GO:0000981,GO:0001228,GO:0001649,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0017151,GO:0045944,GO:0046872,GO:0060218,GO:2000738" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|osteoblast differentiation|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|DEAD/H-box RNA helicase binding|positive regulation of transcription by RNA polymerase II|metal ion binding|hematopoietic stem cell differentiation|positive regulation of stem cell differentiation" Sp8 0.637485788 -0.649534916 0.021688572 Down 2.468852523 1.387161483 0.594881142 1.224352885 0.65661358 0.695556358 trans-acting transcription factor 8 "GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0009953,GO:0009954,GO:0030326,GO:0046872,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|dorsal/ventral pattern formation|proximal/distal pattern formation|embryonic limb morphogenesis|metal ion binding|sequence-specific double-stranded DNA binding" Stab1 1.290656699 0.36810531 0.034313628 Up 1.659586931 1.305532988 1.478438432 1.925227826 1.719655998 2.074970914 stabilin 1 "GO:0005041,GO:0005044,GO:0005509,GO:0005540,GO:0005737,GO:0005887,GO:0006954,GO:0007155,GO:0007267,GO:0016020,GO:0016021,GO:0016525,GO:0030169,GO:0042742" low-density lipoprotein particle receptor activity|scavenger receptor activity|calcium ion binding|hyaluronic acid binding|cytoplasm|integral component of plasma membrane|inflammatory response|cell adhesion|cell-cell signaling|membrane|integral component of membrane|negative regulation of angiogenesis|low-density lipoprotein particle binding|defense response to bacterium Stat1 0.427249323 -1.226849891 5.30E-30 Down 15.07267715 12.66575113 17.000361 6.368543195 5.979225661 6.641916539 signal transducer and activator of transcription 1 "GO:0000785,GO:0000978,GO:0000979,GO:0000981,GO:0001937,GO:0002230,GO:0003677,GO:0003690,GO:0003700,GO:0005164,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006357,GO:0006919,GO:0006952,GO:0007165,GO:0007259,GO:0007584,GO:0008015,GO:0008284,GO:0009612,GO:0009617,GO:0010742,GO:0016525,GO:0016922,GO:0019221,GO:0019899,GO:0030424,GO:0030425,GO:0031663,GO:0031730,GO:0032496,GO:0032727,GO:0032869,GO:0032991,GO:0033209,GO:0034097,GO:0034240,GO:0034340,GO:0035035,GO:0035456,GO:0035458,GO:0042127,GO:0042393,GO:0042493,GO:0042802,GO:0042803,GO:0043124,GO:0043330,GO:0043434,GO:0043565,GO:0044389,GO:0045648,GO:0045893,GO:0045944,GO:0046725,GO:0048471,GO:0048661,GO:0051591,GO:0051607,GO:0051721,GO:0051770,GO:0060333,GO:0060337,GO:0061326,GO:0070106,GO:0071222,GO:0071345,GO:0071346,GO:0071407,GO:0140297,GO:1990841" "chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|negative regulation of endothelial cell proliferation|positive regulation of defense response to virus by host|DNA binding|double-stranded DNA binding|DNA-binding transcription factor activity|tumor necrosis factor receptor binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|activation of cysteine-type endopeptidase activity involved in apoptotic process|defense response|signal transduction|receptor signaling pathway via JAK-STAT|response to nutrient|blood circulation|positive regulation of cell population proliferation|response to mechanical stimulus|response to bacterium|macrophage derived foam cell differentiation|negative regulation of angiogenesis|nuclear receptor binding|cytokine-mediated signaling pathway|enzyme binding|axon|dendrite|lipopolysaccharide-mediated signaling pathway|CCR5 chemokine receptor binding|response to lipopolysaccharide|positive regulation of interferon-alpha production|cellular response to insulin stimulus|protein-containing complex|tumor necrosis factor-mediated signaling pathway|response to cytokine|negative regulation of macrophage fusion|response to type I interferon|histone acetyltransferase binding|response to interferon-beta|cellular response to interferon-beta|regulation of cell population proliferation|histone binding|response to drug|identical protein binding|protein homodimerization activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|response to peptide hormone|sequence-specific DNA binding|ubiquitin-like protein ligase binding|positive regulation of erythrocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation by virus of viral protein levels in host cell|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|response to cAMP|defense response to virus|protein phosphatase 2A binding|positive regulation of nitric-oxide synthase biosynthetic process|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|renal tubule development|interleukin-27-mediated signaling pathway|cellular response to lipopolysaccharide|cellular response to cytokine stimulus|cellular response to interferon-gamma|cellular response to organic cyclic compound|DNA-binding transcription factor binding|promoter-specific chromatin binding" "mmu04062,mmu04217,mmu04380,mmu04620,mmu04621,mmu04625,mmu04630,mmu04658,mmu04659,mmu04917,mmu04919,mmu04933,mmu04935,mmu05140,mmu05145,mmu05152,mmu05160,mmu05161,mmu05162,mmu05164,mmu05165,mmu05167,mmu05168,mmu05169,mmu05171,mmu05200,mmu05212,mmu05235,mmu05321" "Chemokine signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Growth hormone synthesis, secretion and action|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer|Pancreatic cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Inflammatory bowel disease" Stat2 0.657221939 -0.605547455 1.94E-05 Down 6.177837262 5.862149418 7.335866724 4.254344924 4.282481887 4.131196819 signal transducer and activator of transcription 2 "GO:0000978,GO:0000981,GO:0001932,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006357,GO:0006952,GO:0007165,GO:0007259,GO:0019221,GO:0042127,GO:0042802,GO:0043434,GO:0044389,GO:0051607,GO:0060337,GO:0060339,GO:0090140" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|regulation of protein phosphorylation|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|defense response|signal transduction|receptor signaling pathway via JAK-STAT|cytokine-mediated signaling pathway|regulation of cell population proliferation|identical protein binding|response to peptide hormone|ubiquitin-like protein ligase binding|defense response to virus|type I interferon signaling pathway|negative regulation of type I interferon-mediated signaling pathway|regulation of mitochondrial fission" "mmu04062,mmu04217,mmu04380,mmu04621,mmu04625,mmu04630,mmu05160,mmu05161,mmu05162,mmu05164,mmu05165,mmu05167,mmu05168,mmu05169,mmu05171,mmu05200" Chemokine signaling pathway|Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|JAK-STAT signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Coronavirus disease - COVID-19|Pathways in cancer Steap3 1.373659849 0.458024803 0.049918943 Up 1.835999214 1.935074431 1.712274637 2.630964818 2.411684902 2.474416536 STEAP family member 3 "GO:0000293,GO:0005515,GO:0005737,GO:0005768,GO:0005771,GO:0005886,GO:0006811,GO:0006826,GO:0006915,GO:0007049,GO:0008823,GO:0009306,GO:0015677,GO:0016020,GO:0016021,GO:0016491,GO:0033212,GO:0042802,GO:0043065,GO:0046872,GO:0052851,GO:0055072,GO:0098706,GO:1902167,GO:1990182" ferric-chelate reductase activity|protein binding|cytoplasm|endosome|multivesicular body|plasma membrane|ion transport|iron ion transport|apoptotic process|cell cycle|cupric reductase activity|protein secretion|copper ion import|membrane|integral component of membrane|oxidoreductase activity|iron import into cell|identical protein binding|positive regulation of apoptotic process|metal ion binding|ferric-chelate reductase (NADPH) activity|iron ion homeostasis|iron ion import across cell outer membrane|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|exosomal secretion "mmu04115,mmu04216" p53 signaling pathway|Ferroptosis Sun2 0.822391025 -0.282103575 0.003495397 Down 17.04951134 14.70468016 18.11295522 13.4986082 13.64642012 13.6818873 Sad1 and UNC84 domain containing 2 "GO:0000781,GO:0000794,GO:0005515,GO:0005521,GO:0005634,GO:0005635,GO:0005637,GO:0005639,GO:0005768,GO:0006998,GO:0016020,GO:0016021,GO:0021817,GO:0030335,GO:0031022,GO:0031965,GO:0034993,GO:0042802,GO:0043495,GO:0051321,GO:0051642,GO:0090292,GO:0140444" "chromosome, telomeric region|condensed nuclear chromosome|protein binding|lamin binding|nucleus|nuclear envelope|nuclear inner membrane|integral component of nuclear inner membrane|endosome|nuclear envelope organization|membrane|integral component of membrane|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|positive regulation of cell migration|nuclear migration along microfilament|nuclear membrane|meiotic nuclear membrane microtubule tethering complex|identical protein binding|protein-membrane adaptor activity|meiotic cell cycle|centrosome localization|nuclear matrix anchoring at nuclear membrane|cytoskeleton-nuclear membrane anchor activity" Synpo2 1.25254778 0.324865638 0.048379516 Up 1.691659482 1.76932806 2.293141837 2.873408501 1.95116889 2.396123401 synaptopodin 2 "GO:0000045,GO:0001725,GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0015629,GO:0030018,GO:0030054,GO:0030335,GO:0030674,GO:0031005,GO:0032233,GO:0043231,GO:0051371,GO:0051393,GO:0061684,GO:0071889,GO:0099023,GO:2000298" autophagosome assembly|stress fiber|actin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|focal adhesion|actin cytoskeleton|Z disc|cell junction|positive regulation of cell migration|protein-macromolecule adaptor activity|filamin binding|positive regulation of actin filament bundle assembly|intracellular membrane-bounded organelle|muscle alpha-actinin binding|alpha-actinin binding|chaperone-mediated autophagy|14-3-3 protein binding|vesicle tethering complex|regulation of Rho-dependent protein serine/threonine kinase activity Tafa3 0.152756562 -2.710693739 0.03348809 Down 0.202274579 0.159772498 0.021879724 0.054681338 0 0.010738358 TAFA chemokine like family member 3 "GO:0005576,GO:0005615,GO:0014016,GO:0048018,GO:1902692,GO:1903979,GO:1903980" extracellular region|extracellular space|neuroblast differentiation|receptor ligand activity|regulation of neuroblast proliferation|negative regulation of microglial cell activation|positive regulation of microglial cell activation Tap1 0.381475208 -1.390338796 6.58E-07 Down 3.198229514 2.604844409 2.570447691 0.972778332 0.973831711 1.243528783 "transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)" "GO:0000166,GO:0002250,GO:0002376,GO:0002479,GO:0005524,GO:0005739,GO:0005783,GO:0006952,GO:0015031,GO:0015433,GO:0015440,GO:0015833,GO:0016020,GO:0016021,GO:0016887,GO:0019885,GO:0023029,GO:0030176,GO:0030670,GO:0034451,GO:0042270,GO:0042287,GO:0042288,GO:0042605,GO:0042626,GO:0042803,GO:0042824,GO:0042825,GO:0043231,GO:0043531,GO:0044877,GO:0046872,GO:0046967,GO:0046978,GO:0046979,GO:0046980,GO:0055085,GO:1904680" "nucleotide binding|adaptive immune response|immune system process|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP binding|mitochondrion|endoplasmic reticulum|defense response|protein transport|ABC-type peptide antigen transporter activity|ABC-type peptide transporter activity|peptide transport|membrane|integral component of membrane|ATPase|antigen processing and presentation of endogenous peptide antigen via MHC class I|MHC class Ib protein binding|integral component of endoplasmic reticulum membrane|phagocytic vesicle membrane|centriolar satellite|protection from natural killer cell mediated cytotoxicity|MHC protein binding|MHC class I protein binding|peptide antigen binding|ATPase-coupled transmembrane transporter activity|protein homodimerization activity|MHC class I peptide loading complex|TAP complex|intracellular membrane-bounded organelle|ADP binding|protein-containing complex binding|metal ion binding|cytosol to endoplasmic reticulum transport|TAP1 binding|TAP2 binding|tapasin binding|transmembrane transport|peptide transmembrane transporter activity" "mmu02010,mmu04145,mmu04612,mmu05163,mmu05168,mmu05169,mmu05170,mmu05340" ABC transporters|Phagosome|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Primary immunodeficiency Tap2 0.72606853 -0.461822371 0.017409602 Down 5.429219017 5.687735919 4.459026249 3.464644714 4.018264151 3.775330514 "transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)" "GO:0000166,GO:0001916,GO:0002237,GO:0002250,GO:0002376,GO:0002481,GO:0002485,GO:0002489,GO:0002591,GO:0005515,GO:0005524,GO:0005783,GO:0015031,GO:0015433,GO:0015440,GO:0015833,GO:0016020,GO:0016021,GO:0016607,GO:0016887,GO:0019885,GO:0023029,GO:0030176,GO:0042270,GO:0042287,GO:0042288,GO:0042605,GO:0042626,GO:0042802,GO:0042803,GO:0042824,GO:0042825,GO:0043231,GO:0043531,GO:0044877,GO:0046872,GO:0046967,GO:0046968,GO:0046978,GO:0046979,GO:0046980,GO:0055085,GO:0065003,GO:1904680" "nucleotide binding|positive regulation of T cell mediated cytotoxicity|response to molecule of bacterial origin|adaptive immune response|immune system process|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|protein binding|ATP binding|endoplasmic reticulum|protein transport|ABC-type peptide antigen transporter activity|ABC-type peptide transporter activity|peptide transport|membrane|integral component of membrane|nuclear speck|ATPase|antigen processing and presentation of endogenous peptide antigen via MHC class I|MHC class Ib protein binding|integral component of endoplasmic reticulum membrane|protection from natural killer cell mediated cytotoxicity|MHC protein binding|MHC class I protein binding|peptide antigen binding|ATPase-coupled transmembrane transporter activity|identical protein binding|protein homodimerization activity|MHC class I peptide loading complex|TAP complex|intracellular membrane-bounded organelle|ADP binding|protein-containing complex binding|metal ion binding|cytosol to endoplasmic reticulum transport|peptide antigen transport|TAP1 binding|TAP2 binding|tapasin binding|transmembrane transport|protein-containing complex assembly|peptide transmembrane transporter activity" "mmu02010,mmu04145,mmu04612,mmu05163,mmu05168,mmu05169,mmu05170,mmu05340" ABC transporters|Phagosome|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Primary immunodeficiency Tapbp 0.831977124 -0.265384234 0.041623447 Down 14.71049136 12.71527635 12.45676339 10.3485327 12.77254287 10.10491162 TAP binding protein "GO:0000139,GO:0002398,GO:0002479,GO:0005515,GO:0005783,GO:0005789,GO:0005887,GO:0006952,GO:0010468,GO:0016020,GO:0016021,GO:0019885,GO:0030670,GO:0042824,GO:0046978,GO:0046979,GO:0050823,GO:0061635,GO:0062061,GO:0065003" "Golgi membrane|MHC class Ib protein complex assembly|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|defense response|regulation of gene expression|membrane|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|phagocytic vesicle membrane|MHC class I peptide loading complex|TAP1 binding|TAP2 binding|peptide antigen stabilization|regulation of protein complex stability|TAP complex binding|protein-containing complex assembly" "mmu04612,mmu05163,mmu05168,mmu05169,mmu05170" Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection Tbc1d8b 1.351609299 0.434678181 0.044125475 Up 1.210576989 1.992916587 1.679385201 2.327271726 1.974098417 2.189214197 "TBC1 domain family, member 8B" "GO:0003094,GO:0005096,GO:0005509,GO:0005737,GO:0005829,GO:0006886,GO:0016192,GO:0090630" glomerular filtration|GTPase activator activity|calcium ion binding|cytoplasm|cytosol|intracellular protein transport|vesicle-mediated transport|activation of GTPase activity Tbx21 0.176110111 -2.505450352 0.001027462 Down 1.264132687 0.731336606 0.103097054 0.432865357 0.041269913 0.020239616 T-box 21 "GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0001708,GO:0001947,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0010628,GO:0030217,GO:0032703,GO:0043025,GO:0043161,GO:0043565,GO:0045580,GO:0045892,GO:0045893,GO:0048304,GO:0050776,GO:0071310,GO:0072676,GO:1990837,GO:2000320,GO:2000329,GO:2000552" "negative regulation of transcription by RNA polymerase II|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|cell fate specification|heart looping|DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|positive regulation of gene expression|T cell differentiation|negative regulation of interleukin-2 production|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|sequence-specific DNA binding|regulation of T cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of isotype switching to IgG isotypes|regulation of immune response|cellular response to organic substance|lymphocyte migration|sequence-specific double-stranded DNA binding|negative regulation of T-helper 17 cell differentiation|negative regulation of T-helper 17 cell lineage commitment|negative regulation of T-helper 2 cell cytokine production" "mmu04658,mmu04659,mmu05321" Th1 and Th2 cell differentiation|Th17 cell differentiation|Inflammatory bowel disease Tcf7l2 1.278476813 0.354425996 0.001668491 Up 5.227575674 5.359065393 4.869031342 7.104271891 6.784881508 5.881640774 "transcription factor 7 like 2, T cell specific, HMG box" "GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001568,GO:0001678,GO:0001701,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0005977,GO:0006006,GO:0006111,GO:0006355,GO:0006357,GO:0008013,GO:0008134,GO:0009267,GO:0009749,GO:0009791,GO:0010867,GO:0010909,GO:0014003,GO:0016055,GO:0016922,GO:0019901,GO:0021915,GO:0021983,GO:0030282,GO:0030514,GO:0030538,GO:0031641,GO:0032024,GO:0032092,GO:0032252,GO:0032350,GO:0032993,GO:0035019,GO:0035264,GO:0040037,GO:0042475,GO:0042593,GO:0043065,GO:0043433,GO:0043565,GO:0043570,GO:0043588,GO:0044334,GO:0045295,GO:0045444,GO:0045599,GO:0045722,GO:0045892,GO:0045893,GO:0045944,GO:0046621,GO:0046827,GO:0046889,GO:0048557,GO:0048619,GO:0048625,GO:0048641,GO:0048660,GO:0048713,GO:0050679,GO:0051726,GO:0051897,GO:0060070,GO:0060325,GO:0061178,GO:0061629,GO:0070016,GO:0070369,GO:0071664,GO:0090090,GO:1901142,GO:1990907,GO:2000675,GO:2001237" "negative regulation of transcription by RNA polymerase II|chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|blood vessel development|cellular glucose homeostasis|in utero embryonic development|DNA binding|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytosol|glycogen metabolic process|glucose metabolic process|regulation of gluconeogenesis|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|beta-catenin binding|transcription factor binding|cellular response to starvation|response to glucose|post-embryonic development|positive regulation of triglyceride biosynthetic process|positive regulation of heparan sulfate proteoglycan biosynthetic process|oligodendrocyte development|Wnt signaling pathway|nuclear receptor binding|protein kinase binding|neural tube development|pituitary gland development|bone mineralization|negative regulation of BMP signaling pathway|embryonic genitalia morphogenesis|regulation of myelination|positive regulation of insulin secretion|positive regulation of protein binding|secretory granule localization|regulation of hormone metabolic process|protein-DNA complex|somatic stem cell population maintenance|multicellular organism growth|negative regulation of fibroblast growth factor receptor signaling pathway|odontogenesis of dentin-containing tooth|glucose homeostasis|positive regulation of apoptotic process|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|maintenance of DNA repeat elements|skin development|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|gamma-catenin binding|fat cell differentiation|negative regulation of fat cell differentiation|positive regulation of gluconeogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|negative regulation of organ growth|positive regulation of protein export from nucleus|positive regulation of lipid biosynthetic process|embryonic digestive tract morphogenesis|embryonic hindgut morphogenesis|myoblast fate commitment|regulation of skeletal muscle tissue development|regulation of smooth muscle cell proliferation|regulation of oligodendrocyte differentiation|positive regulation of epithelial cell proliferation|regulation of cell cycle|positive regulation of protein kinase B signaling|canonical Wnt signaling pathway|face morphogenesis|regulation of insulin secretion involved in cellular response to glucose stimulus|RNA polymerase II-specific DNA-binding transcription factor binding|armadillo repeat domain binding|beta-catenin-TCF7L2 complex|catenin-TCF7L2 complex|negative regulation of canonical Wnt signaling pathway|insulin metabolic process|beta-catenin-TCF complex|negative regulation of type B pancreatic cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway" "mmu04310,mmu04390,mmu04520,mmu04916,mmu04934,mmu05132,mmu05165,mmu05167,mmu05200,mmu05210,mmu05213,mmu05215,mmu05216,mmu05217,mmu05221,mmu05224,mmu05225,mmu05226,mmu05412" Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Salmonella infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy Tek 1.267182055 0.34162381 0.047360376 Up 3.71582486 3.043409733 2.39185165 3.720627022 3.9393335 3.769106596 TEK receptor tyrosine kinase "GO:0000166,GO:0001525,GO:0001569,GO:0001570,GO:0001666,GO:0001725,GO:0001934,GO:0001935,GO:0001936,GO:0002040,GO:0002720,GO:0004672,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005856,GO:0005884,GO:0005886,GO:0005887,GO:0005902,GO:0005911,GO:0006468,GO:0007160,GO:0007169,GO:0007275,GO:0007507,GO:0009925,GO:0009986,GO:0010595,GO:0014068,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016323,GO:0016324,GO:0016525,GO:0016740,GO:0018108,GO:0019838,GO:0030054,GO:0030097,GO:0030334,GO:0030949,GO:0032526,GO:0032878,GO:0033138,GO:0033674,GO:0034446,GO:0034451,GO:0038023,GO:0042307,GO:0042802,GO:0043066,GO:0043235,GO:0043410,GO:0043552,GO:0043627,GO:0045121,GO:0045765,GO:0045766,GO:0045785,GO:0046777,GO:0048014,GO:0048471,GO:0051894,GO:0051897,GO:0060347,GO:0070374,GO:0072012,GO:0098609,GO:1901222,GO:1902533,GO:2000251,GO:2000352" nucleotide binding|angiogenesis|branching involved in blood vessel morphogenesis|vasculogenesis|response to hypoxia|stress fiber|positive regulation of protein phosphorylation|endothelial cell proliferation|regulation of endothelial cell proliferation|sprouting angiogenesis|positive regulation of cytokine production involved in immune response|protein kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|extracellular region|cytoplasm|cytoskeleton|actin filament|plasma membrane|integral component of plasma membrane|microvillus|cell-cell junction|protein phosphorylation|cell-matrix adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|heart development|basal plasma membrane|cell surface|positive regulation of endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|integral component of membrane|kinase activity|phosphorylation|basolateral plasma membrane|apical plasma membrane|negative regulation of angiogenesis|transferase activity|peptidyl-tyrosine phosphorylation|growth factor binding|cell junction|hemopoiesis|regulation of cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|response to retinoic acid|regulation of establishment or maintenance of cell polarity|positive regulation of peptidyl-serine phosphorylation|positive regulation of kinase activity|substrate adhesion-dependent cell spreading|centriolar satellite|signaling receptor activity|positive regulation of protein import into nucleus|identical protein binding|negative regulation of apoptotic process|receptor complex|positive regulation of MAPK cascade|positive regulation of phosphatidylinositol 3-kinase activity|response to estrogen|membrane raft|regulation of angiogenesis|positive regulation of angiogenesis|positive regulation of cell adhesion|protein autophosphorylation|Tie signaling pathway|perinuclear region of cytoplasm|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|heart trabecula formation|positive regulation of ERK1 and ERK2 cascade|glomerulus vasculature development|cell-cell adhesion|regulation of NIK/NF-kappaB signaling|positive regulation of intracellular signal transduction|positive regulation of actin cytoskeleton reorganization|negative regulation of endothelial cell apoptotic process "mmu04010,mmu04014,mmu04015,mmu04066,mmu04151,mmu05323" MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Rheumatoid arthritis Tet3 0.795862457 -0.329408973 0.001241824 Down 4.76990027 4.926552174 4.504362962 3.713133174 3.586114458 3.988681685 tet methylcytosine dioxygenase 3 "GO:0001939,GO:0001940,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0006211,GO:0006325,GO:0006493,GO:0007275,GO:0008270,GO:0008327,GO:0016491,GO:0035511,GO:0044727,GO:0045944,GO:0046872,GO:0051213,GO:0070579,GO:0070989,GO:0080111,GO:0080182" female pronucleus|male pronucleus|DNA binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|5-methylcytosine catabolic process|chromatin organization|protein O-linked glycosylation|multicellular organism development|zinc ion binding|methyl-CpG binding|oxidoreductase activity|oxidative DNA demethylation|DNA demethylation of male pronucleus|positive regulation of transcription by RNA polymerase II|metal ion binding|dioxygenase activity|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|histone H3-K4 trimethylation Tgm2 0.776234617 -0.365435321 0.015861707 Down 7.603917526 6.341571924 5.990075364 4.891275731 5.534610484 4.977405738 "transglutaminase 2, C polypeptide" "GO:0000166,GO:0000785,GO:0001974,GO:0003810,GO:0005509,GO:0005525,GO:0005576,GO:0005634,GO:0005694,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006508,GO:0007186,GO:0007200,GO:0008233,GO:0008483,GO:0016020,GO:0016740,GO:0016746,GO:0016787,GO:0018149,GO:0018153,GO:0018277,GO:0019904,GO:0031012,GO:0031226,GO:0032471,GO:0042802,GO:0042981,GO:0043065,GO:0043123,GO:0043277,GO:0045785,GO:0046872,GO:0048471,GO:0048661,GO:0050568,GO:0050729,GO:0050769,GO:0051260,GO:0051482,GO:0051561,GO:0060445,GO:0060662,GO:0062023,GO:0071314,GO:0120295,GO:0120297,GO:0120299,GO:1903351,GO:1904015,GO:2000425" nucleotide binding|chromatin|blood vessel remodeling|protein-glutamine gamma-glutamyltransferase activity|calcium ion binding|GTP binding|extracellular region|nucleus|chromosome|cytoplasm|mitochondrion|cytosol|plasma membrane|proteolysis|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|peptidase activity|transaminase activity|membrane|transferase activity|acyltransferase activity|hydrolase activity|peptide cross-linking|isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|protein deamination|protein domain specific binding|extracellular matrix|intrinsic component of plasma membrane|negative regulation of endoplasmic reticulum calcium ion concentration|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|apoptotic cell clearance|positive regulation of cell adhesion|metal ion binding|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|protein-glutamine glutaminase activity|positive regulation of inflammatory response|positive regulation of neurogenesis|protein homooligomerization|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|positive regulation of mitochondrial calcium ion concentration|branching involved in salivary gland morphogenesis|salivary gland cavitation|collagen-containing extracellular matrix|cellular response to cocaine|histone serotonyltransferase activity|histone dopaminyltransferase activity|peptide histaminyltransferase activity|cellular response to dopamine|cellular response to serotonin|regulation of apoptotic cell clearance mmu05016 Huntington disease Tgtp1 0.170005547 -2.556346275 2.25E-08 Down 1.203164414 1.46564432 2.116818513 0.318354789 0.318699521 0.165490744 T cell specific GTPase 1 "GO:0003924,GO:0005525,GO:0005789,GO:0006952,GO:0006955,GO:0009615,GO:0009617,GO:0034341,GO:0035455,GO:0035458" GTPase activity|GTP binding|endoplasmic reticulum membrane|defense response|immune response|response to virus|response to bacterium|response to interferon-gamma|response to interferon-alpha|cellular response to interferon-beta Tgtp2 0.135355492 -2.885174664 3.80E-10 Down 1.200173593 1.520481069 1.625711669 0.149441611 0.187004294 0.256790127 T cell specific GTPase 2 "GO:0003924,GO:0005789,GO:0006952,GO:0035458" GTPase activity|endoplasmic reticulum membrane|defense response|cellular response to interferon-beta Thbs4 0.671430365 -0.574690312 0.028277721 Down 2.638732697 2.314363151 5.209485762 2.250678408 2.137992876 2.016376479 thrombospondin 4 "GO:0001938,GO:0001968,GO:0005178,GO:0005201,GO:0005509,GO:0005515,GO:0005518,GO:0005576,GO:0005604,GO:0005615,GO:0005783,GO:0006986,GO:0007155,GO:0007399,GO:0008083,GO:0008201,GO:0016529,GO:0031012,GO:0031594,GO:0034103,GO:0034976,GO:0042802,GO:0043237,GO:0048266,GO:0048771,GO:0048812,GO:0050731,GO:0051451,GO:0051781,GO:0062023,GO:0071603,GO:0090023" positive regulation of endothelial cell proliferation|fibronectin binding|integrin binding|extracellular matrix structural constituent|calcium ion binding|protein binding|collagen binding|extracellular region|basement membrane|extracellular space|endoplasmic reticulum|response to unfolded protein|cell adhesion|nervous system development|growth factor activity|heparin binding|sarcoplasmic reticulum|extracellular matrix|neuromuscular junction|regulation of tissue remodeling|response to endoplasmic reticulum stress|identical protein binding|laminin-1 binding|behavioral response to pain|tissue remodeling|neuron projection morphogenesis|positive regulation of peptidyl-tyrosine phosphorylation|myoblast migration|positive regulation of cell division|collagen-containing extracellular matrix|endothelial cell-cell adhesion|positive regulation of neutrophil chemotaxis "mmu04145,mmu04151,mmu04510,mmu04512,mmu05144,mmu05165" Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection Tle3 0.823317543 -0.280479128 0.017478321 Down 8.824098214 7.438312544 8.530076953 6.33715391 7.044395517 6.979125178 transducin-like enhancer of split 3 "GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006355,GO:0007275,GO:0007283,GO:0016055,GO:0030154,GO:0090090,GO:0120163,GO:0140297,GO:1990907" "transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription, DNA-templated|multicellular organism development|spermatogenesis|Wnt signaling pathway|cell differentiation|negative regulation of canonical Wnt signaling pathway|negative regulation of cold-induced thermogenesis|DNA-binding transcription factor binding|beta-catenin-TCF complex" "mmu04310,mmu04330" Wnt signaling pathway|Notch signaling pathway Tmem252 0.243525178 -2.037857153 0.000711603 Down 1.143951001 0.86955213 0.726687666 0.085464577 0.29944993 0.314692323 transmembrane protein 252 "GO:0016020,GO:0016021" membrane|integral component of membrane Tmsb10 1.35011318 0.433080354 8.06E-08 Up 77.32698521 90.05289646 87.60822482 111.2314673 117.4388552 114.5315867 "thymosin, beta 10" "GO:0003785,GO:0005737,GO:0030036,GO:0030334,GO:0042989" actin monomer binding|cytoplasm|actin cytoskeleton organization|regulation of cell migration|sequestering of actin monomers Tnfsf10 0.619485146 -0.690858404 0.008426639 Down 1.6054102 1.22133074 1.500712747 1.04270587 0.820156048 0.814890168 "tumor necrosis factor (ligand) superfamily, member 10" "GO:0005125,GO:0005164,GO:0005576,GO:0005615,GO:0005886,GO:0006915,GO:0006955,GO:0008270,GO:0016020,GO:0016021,GO:0032813,GO:0042802,GO:0043065,GO:0043123,GO:0043280,GO:0045569,GO:0046872,GO:0090200,GO:2001238" cytokine activity|tumor necrosis factor receptor binding|extracellular region|extracellular space|plasma membrane|apoptotic process|immune response|zinc ion binding|membrane|integral component of membrane|tumor necrosis factor receptor superfamily binding|identical protein binding|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|TRAIL binding|metal ion binding|positive regulation of release of cytochrome c from mitochondria|positive regulation of extrinsic apoptotic signaling pathway "mmu04060,mmu04061,mmu04068,mmu04210,mmu04217,mmu04650,mmu05132,mmu05164,mmu05417" Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|FoxO signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Salmonella infection|Influenza A|Lipid and atherosclerosis Tob2 0.809112468 -0.305587841 0.019431579 Down 6.692237666 5.910236458 7.342861734 4.452709005 5.744432801 5.981951643 "transducer of ERBB2, 2" "GO:0003714,GO:0005634,GO:0005737,GO:0005829,GO:0008285,GO:0010468,GO:0042809,GO:0045671,GO:0045778" transcription corepressor activity|nucleus|cytoplasm|cytosol|negative regulation of cell population proliferation|regulation of gene expression|vitamin D receptor binding|negative regulation of osteoclast differentiation|positive regulation of ossification mmu03018 RNA degradation Tor3a 0.739463521 -0.435449116 0.039601432 Down 3.588279107 3.023496863 4.814443132 2.720312905 2.884398175 2.702694762 "torsin family 3, member A" "GO:0000166,GO:0005515,GO:0005524,GO:0005635,GO:0005737,GO:0005783,GO:0005788,GO:0016887,GO:0140603" nucleotide binding|protein binding|ATP binding|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|ATPase|ATP hydrolysis activity Trib1 0.712296097 -0.48945101 0.005294183 Down 5.583718707 6.994596393 5.097388763 3.35794484 4.054825343 5.247258683 tribbles pseudokinase 1 "GO:0004672,GO:0004860,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006469,GO:0007254,GO:0008134,GO:0014912,GO:0031434,GO:0031625,GO:0031665,GO:0032436,GO:0032496,GO:0043405,GO:0043433,GO:0045645,GO:0045651,GO:0045659,GO:0048662,GO:0051443,GO:0055106" protein kinase activity|protein kinase inhibitor activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|negative regulation of protein kinase activity|JNK cascade|transcription factor binding|negative regulation of smooth muscle cell migration|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|negative regulation of lipopolysaccharide-mediated signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|response to lipopolysaccharide|regulation of MAP kinase activity|negative regulation of DNA-binding transcription factor activity|positive regulation of eosinophil differentiation|positive regulation of macrophage differentiation|negative regulation of neutrophil differentiation|negative regulation of smooth muscle cell proliferation|positive regulation of ubiquitin-protein transferase activity|ubiquitin-protein transferase regulator activity Trim12a 0.515110501 -0.957046145 0.017083013 Down 1.33996837 1.104936901 1.546422605 0.635307333 0.763194335 0.644604065 tripartite motif-containing 12A "GO:0000209,GO:0004842,GO:0005654,GO:0005737,GO:0005829,GO:0006914,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0046872,GO:0051092,GO:0051607,GO:0061630" protein polyubiquitination|ubiquitin-protein transferase activity|nucleoplasm|cytoplasm|cytosol|autophagy|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|metal ion binding|positive regulation of NF-kappaB transcription factor activity|defense response to virus|ubiquitin protein ligase activity Trim12c 0.517425673 -0.950576458 0.001837064 Down 1.353913107 1.379516614 1.653007423 0.757379475 0.744414161 0.757194763 tripartite motif-containing 12C "GO:0000209,GO:0000932,GO:0003713,GO:0004842,GO:0005654,GO:0005737,GO:0005829,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0030674,GO:0032880,GO:0038187,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0051092,GO:0061630,GO:1990462" protein polyubiquitination|P-body|transcription coactivator activity|ubiquitin-protein transferase activity|nucleoplasm|cytoplasm|cytosol|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|protein-macromolecule adaptor activity|regulation of protein localization|pattern recognition receptor activity|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity|omegasome mmu05170 Human immunodeficiency virus 1 infection Trim14 0.495133293 -1.014111135 0.033452085 Down 0.607888943 0.527521486 0.788269933 0.32709888 0.267916157 0.350377614 tripartite motif-containing 14 "GO:0000209,GO:0002376,GO:0003713,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0008270,GO:0010468,GO:0010508,GO:0016020,GO:0016567,GO:0019901,GO:0031410,GO:0032880,GO:0032897,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0046872,GO:0051091,GO:0051092,GO:0061630" protein polyubiquitination|immune system process|transcription coactivator activity|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|zinc ion binding|regulation of gene expression|positive regulation of autophagy|membrane|protein ubiquitination|protein kinase binding|cytoplasmic vesicle|regulation of protein localization|negative regulation of viral transcription|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|metal ion binding|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity Trim25 0.592120586 -0.756037084 0.000709157 Down 2.414925929 1.637580439 3.38397018 1.672635512 1.241724546 1.347109501 tripartite motif-containing 25 "GO:0002376,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006513,GO:0010494,GO:0016604,GO:0016740,GO:0016874,GO:0030433,GO:0032880,GO:0039552,GO:0043123,GO:0043627,GO:0045087,GO:0046596,GO:0046597,GO:0046872,GO:0051091,GO:0051092,GO:0051607,GO:0061630,GO:1902186,GO:1902187,GO:1990830" immune system process|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cytoplasmic stress granule|nuclear body|transferase activity|ligase activity|ubiquitin-dependent ERAD pathway|regulation of protein localization|RIG-I binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to estrogen|innate immune response|regulation of viral entry into host cell|negative regulation of viral entry into host cell|metal ion binding|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|ubiquitin protein ligase activity|regulation of viral release from host cell|negative regulation of viral release from host cell|cellular response to leukemia inhibitory factor "mmu04064,mmu04622,mmu05164" NF-kappa B signaling pathway|RIG-I-like receptor signaling pathway|Influenza A Trim30a 0.242204529 -2.045702255 1.84E-09 Down 1.385370721 1.553842428 2.899940378 0.408493703 0.554042381 0.388162574 tripartite motif-containing 30A "GO:0000209,GO:0003677,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0009617,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032715,GO:0032720,GO:0032880,GO:0034122,GO:0042803,GO:0043123,GO:0045087,GO:0045732,GO:0046596,GO:0046598,GO:0046872,GO:0051092,GO:0051865,GO:0061630,GO:1900226,GO:2000378" protein polyubiquitination|DNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|zinc ion binding|response to bacterium|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|regulation of protein localization|negative regulation of toll-like receptor signaling pathway|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of protein catabolic process|regulation of viral entry into host cell|positive regulation of viral entry into host cell|metal ion binding|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|ubiquitin protein ligase activity|negative regulation of NLRP3 inflammasome complex assembly|negative regulation of reactive oxygen species metabolic process Trim30d 0.443137944 -1.174172232 0.002569162 Down 0.893763771 0.78902024 1.364141265 0.472566902 0.44604556 0.397727155 tripartite motif-containing 30D "GO:0000209,GO:0005654,GO:0005737,GO:0005829,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0051092,GO:0061630" protein polyubiquitination|nucleoplasm|cytoplasm|cytosol|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity mmu05170 Human immunodeficiency virus 1 infection Trim34a 0.38867672 -1.363357395 9.03E-05 Down 1.437333644 1.499703729 2.422286888 0.590607566 0.571538872 0.908540604 tripartite motif-containing 34A "GO:0000209,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0010468,GO:0010508,GO:0016567,GO:0019901,GO:0032880,GO:0042803,GO:0043123,GO:0045087,GO:0046596,GO:0046872,GO:0051092,GO:0051607,GO:0061630" protein polyubiquitination|nucleoplasm|cytoplasm|cytosol|zinc ion binding|regulation of gene expression|positive regulation of autophagy|protein ubiquitination|protein kinase binding|regulation of protein localization|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|metal ion binding|positive regulation of NF-kappaB transcription factor activity|defense response to virus|ubiquitin protein ligase activity Tsc22d3 0.72938901 -0.455239632 0.024434046 Down 20.09227944 21.19856342 32.79508857 15.98821642 18.49701763 18.25778805 "TSC22 domain family, member 3" "GO:0000122,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0006970,GO:0043426,GO:0048642,GO:0070236" negative regulation of transcription by RNA polymerase II|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|response to osmotic stress|MRF binding|negative regulation of skeletal muscle tissue development|negative regulation of activation-induced cell death of T cells Tshz1 0.79270619 -0.335141853 0.00261139 Down 9.835938037 7.4861826 6.111096149 7.02622876 5.547705631 5.754318989 teashirt zinc finger family member 1 "GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0007275,GO:0009952,GO:0010468,GO:0042474,GO:0046872,GO:0060023" "DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|multicellular organism development|anterior/posterior pattern specification|regulation of gene expression|middle ear morphogenesis|metal ion binding|soft palate development" Tspan11 0.683512342 -0.548960706 0.021096986 Down 1.67131165 1.431168561 1.686952921 1.046379888 0.966152736 1.266848298 tetraspanin 11 "GO:0005887,GO:0016020,GO:0016021,GO:0016477" integral component of plasma membrane|membrane|integral component of membrane|cell migration Tspan6 1.244820973 0.315938273 0.049171582 Up 7.015704017 7.158867456 6.391784354 9.138734467 9.346974691 7.198137461 tetraspanin 6 "GO:0005887,GO:0016020,GO:0016021,GO:0039532,GO:1901223" integral component of plasma membrane|membrane|integral component of membrane|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|negative regulation of NIK/NF-kappaB signaling Tspoap1 0.822691561 -0.28157645 0.000112566 Down 13.11952724 13.14897011 13.82756015 10.42327564 10.43943851 12.14766757 TSPO associated protein 1 "GO:0005737,GO:0005739,GO:0007274,GO:0030156,GO:0044305,GO:0098978,GO:0099626" cytoplasm|mitochondrion|neuromuscular synaptic transmission|benzodiazepine receptor binding|calyx of Held|glutamatergic synapse|voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Tst 1.25943762 0.332779667 0.020946697 Up 25.37136481 24.45788861 16.99907634 27.73375936 27.42928752 27.79431891 "thiosulfate sulfurtransferase, mitochondrial" "GO:0003723,GO:0004792,GO:0005739,GO:0005743,GO:0008097,GO:0016740,GO:0019346,GO:0030855,GO:0035928,GO:0051029" RNA binding|thiosulfate sulfurtransferase activity|mitochondrion|mitochondrial inner membrane|5S rRNA binding|transferase activity|transsulfuration|epithelial cell differentiation|rRNA import into mitochondrion|rRNA transport "mmu00270,mmu00920,mmu04122" Cysteine and methionine metabolism|Sulfur metabolism|Sulfur relay system Tstd3 1.232319054 0.301375826 0.035829961 Up 10.90617734 12.21003317 12.50032614 14.71703248 14.53387473 14.51579644 thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 GO:0004792 thiosulfate sulfurtransferase activity Uba7 0.401095922 -1.317980798 0.000122924 Down 1.894771213 1.336743019 1.963708692 0.665445252 0.816053146 0.588062617 ubiquitin-like modifier activating enzyme 7 "GO:0004839,GO:0004842,GO:0005634,GO:0005737,GO:0006464,GO:0006974,GO:0019782,GO:0019941,GO:0032020,GO:0032446" ubiquitin activating enzyme activity|ubiquitin-protein transferase activity|nucleus|cytoplasm|cellular protein modification process|cellular response to DNA damage stimulus|ISG15 activating enzyme activity|modification-dependent protein catabolic process|ISG15-protein conjugation|protein modification by small protein conjugation "mmu04120,mmu05012,mmu05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases Ube2l6 0.713605044 -0.486802282 0.030254411 Down 6.977793695 5.976123327 6.980688883 4.740757676 4.745891234 4.69220547 ubiquitin-conjugating enzyme E2L 6 "GO:0000151,GO:0000166,GO:0000209,GO:0005515,GO:0005524,GO:0005634,GO:0006511,GO:0016740,GO:0019787,GO:0019941,GO:0031625,GO:0032020,GO:0042296,GO:0043130,GO:0061631" ubiquitin ligase complex|nucleotide binding|protein polyubiquitination|protein binding|ATP binding|nucleus|ubiquitin-dependent protein catabolic process|transferase activity|ubiquitin-like protein transferase activity|modification-dependent protein catabolic process|ubiquitin protein ligase binding|ISG15-protein conjugation|ISG15 transferase activity|ubiquitin binding|ubiquitin conjugating enzyme activity "mmu04120,mmu05012,mmu05022" Ubiquitin mediated proteolysis|Parkinson disease|Pathways of neurodegeneration - multiple diseases Ugt8a 1.215394997 0.281425258 0.000366661 Up 11.94440677 12.31963339 10.39573736 13.86780909 14.6894106 13.4358263 UDP galactosyltransferase 8A "GO:0002175,GO:0003851,GO:0005783,GO:0006629,GO:0006665,GO:0006682,GO:0007010,GO:0008120,GO:0008194,GO:0008489,GO:0009247,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030913,GO:0042552,GO:0043231,GO:0047263,GO:0048812" "protein localization to paranode region of axon|2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|endoplasmic reticulum|lipid metabolic process|sphingolipid metabolic process|galactosylceramide biosynthetic process|cytoskeleton organization|ceramide glucosyltransferase activity|UDP-glycosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity|glycolipid biosynthetic process|membrane|integral component of membrane|transferase activity|glycosyltransferase activity|paranodal junction assembly|myelination|intracellular membrane-bounded organelle|N-acylsphingosine galactosyltransferase activity|neuron projection morphogenesis" "mmu00565,mmu00600" Ether lipid metabolism|Sphingolipid metabolism Usp18 0.159975953 -2.644073038 1.21E-10 Down 2.689039423 2.448654972 5.704789029 0.712864332 0.505492352 0.408312252 ubiquitin specific peptidase 18 "GO:0004197,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0006508,GO:0006511,GO:0008233,GO:0008234,GO:0009617,GO:0016579,GO:0016787,GO:0019785,GO:0035634,GO:0043231,GO:0050727,GO:0060339" cysteine-type endopeptidase activity|thiol-dependent deubiquitinase|protein binding|nucleus|cytosol|proteolysis|ubiquitin-dependent protein catabolic process|peptidase activity|cysteine-type peptidase activity|response to bacterium|protein deubiquitination|hydrolase activity|ISG15-specific protease activity|response to stilbenoid|intracellular membrane-bounded organelle|regulation of inflammatory response|negative regulation of type I interferon-mediated signaling pathway Usp29 1.227419166 0.295628017 0.001884574 Up 6.866631475 8.421012271 7.17119715 9.558454631 9.773485383 8.174651325 ubiquitin specific peptidase 29 "GO:0000082,GO:0004197,GO:0004843,GO:0005634,GO:0005829,GO:0006511,GO:0008233,GO:0008234,GO:0016579,GO:0016787" G1/S transition of mitotic cell cycle|cysteine-type endopeptidase activity|thiol-dependent deubiquitinase|nucleus|cytosol|ubiquitin-dependent protein catabolic process|peptidase activity|cysteine-type peptidase activity|protein deubiquitination|hydrolase activity Vasn 0.745731162 -0.423272465 0.040033484 Down 4.014378068 3.511516498 3.036129031 2.589758923 2.609076401 2.623876758 vasorin "GO:0005515,GO:0005615,GO:0005739,GO:0005886,GO:0009986,GO:0010719,GO:0016020,GO:0016021,GO:0030512,GO:0031012,GO:0050431,GO:0070062,GO:0071456,GO:0071461" protein binding|extracellular space|mitochondrion|plasma membrane|cell surface|negative regulation of epithelial to mesenchymal transition|membrane|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|transforming growth factor beta binding|extracellular exosome|cellular response to hypoxia|cellular response to redox state Vat1l 1.207064494 0.271502763 0.00162335 Up 25.99801773 33.95902863 27.11389545 36.62056738 36.63273045 31.27942567 vesicle amine transport protein 1 like "GO:0008270,GO:0016491" zinc ion binding|oxidoreductase activity Vav3 1.389930965 0.47501323 0.00477259 Up 2.356865851 2.293138253 2.246837354 3.150372807 2.929904464 3.513447682 vav 3 oncogene "GO:0001525,GO:0001772,GO:0005085,GO:0005154,GO:0005515,GO:0005737,GO:0005886,GO:0006906,GO:0006974,GO:0007229,GO:0007264,GO:0016477,GO:0030031,GO:0030032,GO:0030593,GO:0030890,GO:0035556,GO:0042493,GO:0043087,GO:0043552,GO:0045785,GO:0046872,GO:0050853" angiogenesis|immunological synapse|guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|protein binding|cytoplasm|plasma membrane|vesicle fusion|cellular response to DNA damage stimulus|integrin-mediated signaling pathway|small GTPase mediated signal transduction|cell migration|cell projection assembly|lamellipodium assembly|neutrophil chemotaxis|positive regulation of B cell proliferation|intracellular signal transduction|response to drug|regulation of GTPase activity|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of cell adhesion|metal ion binding|B cell receptor signaling pathway "mmu04015,mmu04024,mmu04062,mmu04510,mmu04650,mmu04660,mmu04662,mmu04664,mmu04666,mmu04670,mmu04810,mmu05135,mmu05205,mmu05417" Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Yersinia infection|Proteoglycans in cancer|Lipid and atherosclerosis Vwa5b1 1.411089507 0.496809502 0.018846477 Up 0.71151344 1.103643544 0.803158607 1.284631552 1.430145848 0.962348998 von Willebrand factor A domain containing 5B1 GO:0005576 extracellular region Vwf 0.831561722 -0.266104744 0.037568734 Down 5.055398775 4.079821819 3.504515122 3.485699656 3.465896639 3.439964454 Von Willebrand factor "GO:0001889,GO:0001890,GO:0002020,GO:0005178,GO:0005201,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005737,GO:0005783,GO:0007155,GO:0007596,GO:0007599,GO:0009897,GO:0019865,GO:0030168,GO:0031012,GO:0031589,GO:0033093,GO:0042802,GO:0047485,GO:0051087,GO:0062023,GO:1902533" liver development|placenta development|protease binding|integrin binding|extracellular matrix structural constituent|protein binding|collagen binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum|cell adhesion|blood coagulation|hemostasis|external side of plasma membrane|immunoglobulin binding|platelet activation|extracellular matrix|cell-substrate adhesion|Weibel-Palade body|identical protein binding|protein N-terminus binding|chaperone binding|collagen-containing extracellular matrix|positive regulation of intracellular signal transduction "mmu04151,mmu04510,mmu04512,mmu04610,mmu04611,mmu04613,mmu05165,mmu05171" PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Complement and coagulation cascades|Platelet activation|Neutrophil extracellular trap formation|Human papillomavirus infection|Coronavirus disease - COVID-19 Xaf1 0.504888626 -0.985962919 0.000223279 Down 2.537154539 2.257592192 2.845745778 1.260574835 1.415419028 1.170856539 XIAP associated factor 1 "GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006915,GO:0031333,GO:0035456,GO:0046872" nucleus|nucleoplasm|cytoplasm|mitochondrion|apoptotic process|negative regulation of protein-containing complex assembly|response to interferon-beta|metal ion binding Xdh 0.421935374 -1.24490605 5.47E-06 Down 1.875607222 1.665595392 4.265313259 1.037475876 0.970120238 1.0075065 xanthine dehydrogenase "GO:0000255,GO:0001933,GO:0001937,GO:0004854,GO:0004855,GO:0005506,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005777,GO:0005829,GO:0006147,GO:0006148,GO:0006149,GO:0006154,GO:0006157,GO:0006161,GO:0006196,GO:0006204,GO:0006919,GO:0007595,GO:0009055,GO:0009114,GO:0009115,GO:0010044,GO:0010629,GO:0016226,GO:0016491,GO:0016529,GO:0019428,GO:0030151,GO:0030856,GO:0042802,GO:0042803,GO:0043546,GO:0045602,GO:0046038,GO:0046055,GO:0046059,GO:0046872,GO:0050421,GO:0050660,GO:0051536,GO:0051537,GO:0051898,GO:0070674,GO:0070675,GO:0071949,GO:1900745,GO:1900747,GO:2000379,GO:2001213" "allantoin metabolic process|negative regulation of protein phosphorylation|negative regulation of endothelial cell proliferation|xanthine dehydrogenase activity|xanthine oxidase activity|iron ion binding|protein binding|extracellular region|extracellular space|cytoplasm|peroxisome|cytosol|guanine catabolic process|inosine catabolic process|deoxyinosine catabolic process|adenosine catabolic process|deoxyadenosine catabolic process|deoxyguanosine catabolic process|AMP catabolic process|IMP catabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|lactation|electron transfer activity|hypoxanthine catabolic process|xanthine catabolic process|response to aluminum ion|negative regulation of gene expression|iron-sulfur cluster assembly|oxidoreductase activity|sarcoplasmic reticulum|allantoin biosynthetic process|molybdenum ion binding|regulation of epithelial cell differentiation|identical protein binding|protein homodimerization activity|molybdopterin cofactor binding|negative regulation of endothelial cell differentiation|GMP catabolic process|dGMP catabolic process|dAMP catabolic process|metal ion binding|nitrite reductase (NO-forming) activity|flavin adenine dinucleotide binding|iron-sulfur cluster binding|2 iron, 2 sulfur cluster binding|negative regulation of protein kinase B signaling|hypoxanthine dehydrogenase activity|hypoxanthine oxidase activity|FAD binding|positive regulation of p38MAPK cascade|negative regulation of vascular endothelial growth factor signaling pathway|positive regulation of reactive oxygen species metabolic process|negative regulation of vasculogenesis" "mmu00230,mmu00232,mmu00983,mmu04146" Purine metabolism|Caffeine metabolism|Drug metabolism - other enzymes|Peroxisome Xlr3b 0.327251125 -1.611529941 0.049917256 Down 2.314620501 1.041501685 2.936425017 0.469673636 1.234228339 0.461174106 X-linked lymphocyte-regulated 3B "GO:0000795,GO:0007286,GO:0051321,GO:0051965,GO:0061003" synaptonemal complex|spermatid development|meiotic cell cycle|positive regulation of synapse assembly|positive regulation of dendritic spine morphogenesis Zbp1 0.057662529 -4.116222071 4.17E-08 Down 0.828982069 0.939431459 1.484673874 0.024330919 0.073071798 0.095562442 Z-DNA binding protein 1 "GO:0002218,GO:0002376,GO:0003677,GO:0003692,GO:0003723,GO:0003725,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0012501,GO:0016032,GO:0042802,GO:0043065,GO:0045087,GO:0050727,GO:0050729,GO:0051607,GO:0060340,GO:0060545,GO:0070269,GO:2000659" activation of innate immune response|immune system process|DNA binding|left-handed Z-DNA binding|RNA binding|double-stranded RNA binding|protein binding|nucleus|cytoplasm|cytosol|apoptotic process|programmed cell death|viral process|identical protein binding|positive regulation of apoptotic process|innate immune response|regulation of inflammatory response|positive regulation of inflammatory response|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|positive regulation of necroptotic process|pyroptosis|regulation of interleukin-1-mediated signaling pathway "mmu04217,mmu04623" Necroptosis|Cytosolic DNA-sensing pathway Zfp276 0.768748425 -0.379416545 0.033924542 Down 4.188562673 5.063249319 5.567944252 3.094320422 3.995812458 4.314778968 zinc finger protein (C2H2 type) 276 "GO:0000775,GO:0000776,GO:0003677,GO:0005634,GO:0005694,GO:0006357,GO:0008270,GO:0043035,GO:0046872,GO:1990837" "chromosome, centromeric region|kinetochore|DNA binding|nucleus|chromosome|regulation of transcription by RNA polymerase II|zinc ion binding|chromatin insulator sequence binding|metal ion binding|sequence-specific double-stranded DNA binding" Zfp36 0.668468788 -0.581067895 0.032068509 Down 4.322891552 2.985696014 3.93537518 2.503506835 2.416709994 2.516730306 zinc finger protein 36 "GO:0000122,GO:0000165,GO:0000178,GO:0000288,GO:0000289,GO:0000932,GO:0003677,GO:0003729,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006357,GO:0006402,GO:0007275,GO:0009611,GO:0010494,GO:0010837,GO:0019899,GO:0019901,GO:0019957,GO:0030014,GO:0031072,GO:0031086,GO:0032680,GO:0032703,GO:0032897,GO:0035278,GO:0035556,GO:0035925,GO:0038066,GO:0042594,GO:0043488,GO:0044344,GO:0044877,GO:0045600,GO:0045616,GO:0045638,GO:0045647,GO:0046872,GO:0050728,GO:0050779,GO:0051028,GO:0060213,GO:0061014,GO:0061158,GO:0070063,GO:0070578,GO:0070935,GO:0071222,GO:0071356,GO:0071364,GO:0071385,GO:0071889,GO:0097011,GO:1900153,GO:1901835,GO:1902172,GO:1904246,GO:1904582,GO:1990904,GO:2000637" "negative regulation of transcription by RNA polymerase II|MAPK cascade|exosome (RNase complex)|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|P-body|DNA binding|mRNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|mRNA catabolic process|multicellular organism development|response to wounding|cytoplasmic stress granule|regulation of keratinocyte proliferation|enzyme binding|protein kinase binding|C-C chemokine binding|CCR4-NOT complex|heat shock protein binding|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|regulation of tumor necrosis factor production|negative regulation of interleukin-2 production|negative regulation of viral transcription|miRNA mediated inhibition of translation|intracellular signal transduction|mRNA 3'-UTR AU-rich region binding|p38MAPK cascade|response to starvation|regulation of mRNA stability|cellular response to fibroblast growth factor stimulus|protein-containing complex binding|positive regulation of fat cell differentiation|regulation of keratinocyte differentiation|negative regulation of myeloid cell differentiation|negative regulation of erythrocyte differentiation|metal ion binding|negative regulation of inflammatory response|RNA destabilization|mRNA transport|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|RNA polymerase binding|RISC-loading complex|3'-UTR-mediated mRNA stabilization|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to glucocorticoid stimulus|14-3-3 protein binding|cellular response to granulocyte macrophage colony-stimulating factor stimulus|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|regulation of keratinocyte apoptotic process|negative regulation of polynucleotide adenylyltransferase activity|positive regulation of intracellular mRNA localization|ribonucleoprotein complex|positive regulation of gene silencing by miRNA" "mmu05166,mmu05167" Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection Zfp46 0.820668019 -0.285129362 0.008544396 Down 8.717866505 8.252680529 8.306119368 6.631690041 6.454968956 7.675122474 zinc finger protein 46 "GO:0000122,GO:0000977,GO:0000981,GO:0001227,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0046872" "negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|metal ion binding" mmu05168 Herpes simplex virus 1 infection Zfp941 1.266389926 0.340721685 0.003269042 Up 7.388328817 7.288207897 7.84801465 9.554476208 9.201089649 9.725122517 zinc finger protein 941 "GO:0000978,GO:0000981,GO:0005634,GO:0006357" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II" mmu05168 Herpes simplex virus 1 infection Zfp965 0.459805648 -1.120903906 0.017953561 Down 0.319602399 0.342607065 0.350318355 0.13132622 0.124164626 0.222079958 zinc finger protein 965 "GO:0000978,GO:0001227,GO:0005654,GO:0006357,GO:1990837" "RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|regulation of transcription by RNA polymerase II|sequence-specific double-stranded DNA binding" Zic4 1.54286086 0.625607961 0.012856062 Up 0.386622968 0.52238184 0.347632076 0.682624364 0.621239589 0.609337396 zinc finger protein of the cerebellum 4 "GO:0000977,GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0007417,GO:0046872,GO:1990837" "RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|metal ion binding|sequence-specific double-stranded DNA binding"