##Databases: KEGG PATHWAY ##ListHits: The number of DEGs in this entry id Term Classification ListHits p-value Gene mmu00230 Purine metabolism Metabolism 2 0.278905518 Papss2;Xdh mmu00232 Caffeine metabolism Metabolism 1 0.045005232 Xdh mmu00260 "Glycine, serine and threonine metabolism" Metabolism 1 0.264794151 Alas2 mmu00450 Selenocompound metabolism Metabolism 1 0.122393432 Papss2 mmu00480 Glutathione metabolism Metabolism 1 0.421310054 Nat8f3 mmu00511 Other glycan degradation Metabolism 1 0.129114485 Hexdc mmu00513 Various types of N-glycan biosynthesis Metabolism 1 0.264794151 Hexdc mmu00515 Mannose type O-glycan biosynthesis Metabolism 1 0.161966763 B3galnt2 mmu00564 Glycerophospholipid metabolism Metabolism 1 0.526892916 Pla2g4e mmu00565 Ether lipid metabolism Metabolism 1 0.303427425 Pla2g4e mmu00590 Arachidonic acid metabolism Metabolism 1 0.480756567 Pla2g4e mmu00591 Linoleic acid metabolism Metabolism 1 0.314093421 Pla2g4e mmu00592 alpha-Linolenic acid metabolism Metabolism 1 0.16838922 Pla2g4e mmu00760 Nicotinate and nicotinamide metabolism Metabolism 1 0.264794151 Sirt7 mmu00860 Porphyrin and chlorophyll metabolism Metabolism 1 0.281603049 Alas2 mmu00920 Sulfur metabolism Metabolism 1 0.080981007 Papss2 mmu00983 Drug metabolism - other enzymes Metabolism 1 0.508181879 Xdh mmu01521 EGFR tyrosine kinase inhibitor resistance Human Diseases 1 0.456054425 Kdr mmu01522 Endocrine resistance Human Diseases 1 0.511981481 Fos mmu03013 RNA transport Genetic Information Processing 2 0.393513058 Eif2s3y;Thoc1 mmu03015 mRNA surveillance pathway Genetic Information Processing 1 0.544902479 Pcf11 mmu03040 Spliceosome Genetic Information Processing 1 0.639615656 Thoc1 mmu03320 PPAR signaling pathway Organismal Systems 2 0.14795417 Fabp7;Plin4 mmu04010 MAPK signaling pathway Environmental Information Processing 5 0.073511815 Dusp1;Fgf15;Fos;Kdr;Pla2g4e mmu04014 Ras signaling pathway Environmental Information Processing 3 0.259043275 Fgf15;Kdr;Pla2g4e mmu04015 Rap1 signaling pathway Environmental Information Processing 3 0.224288771 Fgf15;Kdr;Vav3 mmu04020 Calcium signaling pathway Environmental Information Processing 3 0.277751088 Fgf15;Kdr;Ret mmu04024 cAMP signaling pathway Environmental Information Processing 4 0.08168384 Fos;Nfkbia;Oxt;Vav3 mmu04060 Cytokine-cytokine receptor interaction Environmental Information Processing 3 0.384980272 Ccl27b;Cxcl12;Inhba mmu04061 Viral protein interaction with cytokine and cytokine receptor Environmental Information Processing 2 0.161307438 Ccl27b;Cxcl12 mmu04062 Chemokine signaling pathway Organismal Systems 4 0.057917487 Ccl27b;Cxcl12;Nfkbia;Vav3 mmu04064 NF-kappa B signaling pathway Environmental Information Processing 2 0.191389358 Cxcl12;Nfkbia mmu04068 FoxO signaling pathway Environmental Information Processing 3 0.078408096 Klf2;Sgk1;Skp2 mmu04072 Phospholipase D signaling pathway Environmental Information Processing 1 0.684367804 Pla2g4e mmu04080 Neuroactive ligand-receptor interaction Environmental Information Processing 5 0.137675923 Apln;Chrng;Oxt;Sctr;Vipr1 mmu04110 Cell cycle Cellular Processes 1 0.613450497 Skp2 mmu04114 Oocyte meiosis Cellular Processes 1 0.60122926 Cpeb1 mmu04120 Ubiquitin mediated proteolysis Genetic Information Processing 1 0.674357537 Skp2 mmu04140 Autophagy - animal Cellular Processes 1 0.656081815 Ddit4 mmu04141 Protein processing in endoplasmic reticulum Genetic Information Processing 1 0.736313377 Cryaa mmu04146 Peroxisome Cellular Processes 1 0.484764762 Xdh mmu04150 mTOR signaling pathway Environmental Information Processing 5 0.006651605 Ddit4;Fzd4;Fzd7;Sgk1;Skp2 mmu04151 PI3K-Akt signaling pathway Environmental Information Processing 7 0.019185564 Col4a5;Col6a1;Ddit4;Fgf15;Kdr;Sgk1;Tnxb mmu04152 AMPK signaling pathway Environmental Information Processing 1 0.622373634 Adipor2 mmu04210 Apoptosis Cellular Processes 2 0.278905518 Fos;Nfkbia mmu04211 Longevity regulating pathway Organismal Systems 1 0.500495063 Adipor2 mmu04217 Necroptosis Cellular Processes 1 0.740410382 Pla2g4e mmu04270 Vascular smooth muscle contraction Organismal Systems 1 0.666645269 Pla2g4e mmu04310 Wnt signaling pathway Environmental Information Processing 4 0.039242243 Fzd4;Fzd7;Sfrp5;Tcf7l2 mmu04350 TGF-beta signaling pathway Environmental Information Processing 1 0.519494162 Inhba mmu04360 Axon guidance Organismal Systems 1 0.75426225 Cxcl12 mmu04370 VEGF signaling pathway Environmental Information Processing 2 0.072374255 Kdr;Pla2g4e mmu04371 Apelin signaling pathway Environmental Information Processing 2 0.281748812 Apln;Klf2 mmu04380 Osteoclast differentiation Organismal Systems 3 0.06890994 Fos;Junb;Nfkbia mmu04390 Hippo signaling pathway Environmental Information Processing 3 0.11822421 Fzd4;Fzd7;Tcf7l2 mmu04510 Focal adhesion Cellular Processes 5 0.018453612 Col4a5;Col6a1;Kdr;Tnxb;Vav3 mmu04512 ECM-receptor interaction Environmental Information Processing 3 0.029526655 Col4a5;Col6a1;Tnxb mmu04514 Cell adhesion molecules Environmental Information Processing 1 0.72579019 Cldn5 mmu04520 Adherens junction Cellular Processes 1 0.421310054 Tcf7l2 mmu04530 Tight junction Cellular Processes 1 0.723636453 Cldn5 mmu04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes 3 0.091415142 Fzd4;Fzd7;Inhba mmu04611 Platelet activation Organismal Systems 1 0.616447709 Pla2g4e mmu04620 Toll-like receptor signaling pathway Organismal Systems 2 0.174874582 Fos;Nfkbia mmu04621 NOD-like receptor signaling pathway Organismal Systems 1 0.791595736 Nfkbia mmu04622 RIG-I-like receptor signaling pathway Organismal Systems 1 0.416816168 Nfkbia mmu04623 Cytosolic DNA-sensing pathway Organismal Systems 1 0.384382123 Nfkbia mmu04625 C-type lectin receptor signaling pathway Organismal Systems 2 0.21091038 Egr2;Nfkbia mmu04650 Natural killer cell mediated cytotoxicity Organismal Systems 1 0.67180651 Vav3 mmu04657 IL-17 signaling pathway Organismal Systems 2 0.153267523 Fos;Nfkbia mmu04658 Th1 and Th2 cell differentiation Organismal Systems 2 0.142680868 Fos;Nfkbia mmu04659 Th17 cell differentiation Organismal Systems 2 0.185859175 Fos;Nfkbia mmu04660 T cell receptor signaling pathway Organismal Systems 3 0.043925134 Fos;Nfkbia;Vav3 mmu04662 B cell receptor signaling pathway Organismal Systems 3 0.020877646 Fos;Nfkbia;Vav3 mmu04664 Fc epsilon RI signaling pathway Organismal Systems 2 0.090385429 Pla2g4e;Vav3 mmu04666 Fc gamma R-mediated phagocytosis Organismal Systems 2 0.155938469 Pla2g4e;Vav3 mmu04668 TNF signaling pathway Environmental Information Processing 3 0.055144306 Fos;Junb;Nfkbia mmu04670 Leukocyte transendothelial migration Organismal Systems 3 0.061221093 Cldn5;Cxcl12;Vav3 mmu04672 Intestinal immune network for IgA production Organismal Systems 1 0.276042571 Cxcl12 mmu04710 Circadian rhythm Organismal Systems 4 7.35E-05 Bhlhe40;Nr1d1;Per1;Per2 mmu04713 Circadian entrainment Organismal Systems 3 0.03879628 Fos;Per1;Per2 mmu04722 Neurotrophin signaling pathway Organismal Systems 1 0.607386708 Nfkbia mmu04724 Glutamatergic synapse Organismal Systems 1 0.582180613 Pla2g4e mmu04725 Cholinergic synapse Organismal Systems 1 0.578919873 Fos mmu04726 Serotonergic synapse Organismal Systems 2 0.264684633 Dusp1;Pla2g4e mmu04728 Dopaminergic synapse Organismal Systems 1 0.647943533 Fos mmu04730 Long-term depression Organismal Systems 1 0.369943905 Pla2g4e mmu04740 Olfactory transduction Organismal Systems 1 0.999922281 Ano2 mmu04750 Inflammatory mediator regulation of TRP channels Organismal Systems 1 0.625302691 Pla2g4e mmu04810 Regulation of actin cytoskeleton Cellular Processes 3 0.236450694 Cxcl12;Fgf15;Vav3 mmu04912 GnRH signaling pathway Organismal Systems 1 0.500495063 Pla2g4e mmu04913 Ovarian steroidogenesis Organismal Systems 1 0.384382123 Pla2g4e mmu04914 Progesterone-mediated oocyte maturation Organismal Systems 1 0.500495063 Cpeb1 mmu04915 Estrogen signaling pathway Organismal Systems 1 0.645188853 Fos mmu04916 Melanogenesis Organismal Systems 3 0.040808744 Fzd4;Fzd7;Tcf7l2 mmu04917 Prolactin signaling pathway Organismal Systems 1 0.43458808 Fos mmu04919 Thyroid hormone signaling pathway Organismal Systems 1 0.60431978 Med12 mmu04920 Adipocytokine signaling pathway Organismal Systems 2 0.102244153 Adipor2;Nfkbia mmu04921 Oxytocin signaling pathway Organismal Systems 3 0.111669061 Fos;Oxt;Pla2g4e mmu04922 Glucagon signaling pathway Organismal Systems 1 0.551915727 Sik1 mmu04926 Relaxin signaling pathway Organismal Systems 3 0.075637686 Col4a5;Fos;Nfkbia mmu04928 "Parathyroid hormone synthesis, secretion and action" Organismal Systems 1 0.565624421 Fos mmu04931 Insulin resistance Human Diseases 1 0.572323027 Nfkbia mmu04932 Non-alcoholic fatty liver disease Human Diseases 2 0.310120595 Adipor2;Fos mmu04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases 1 0.541355427 Col4a5 mmu04934 Cushing syndrome Human Diseases 3 0.126617343 Fzd4;Fzd7;Tcf7l2 mmu04935 "Growth hormone synthesis, secretion and action" Organismal Systems 2 0.222158655 Fos;Junb mmu04960 Aldosterone-regulated sodium reabsorption Organismal Systems 1 0.253373648 Sgk1 mmu04971 Gastric acid secretion Organismal Systems 1 0.438947055 Kcnj10 mmu04972 Pancreatic secretion Organismal Systems 1 0.582180613 Sctr mmu04974 Protein digestion and absorption Organismal Systems 4 0.009207514 Col4a5;Col5a1;Col6a1;Eln mmu04976 Bile secretion Organismal Systems 1 0.537781151 Sctr mmu05010 Alzheimer disease Human Diseases 2 0.762751127 Fzd4;Fzd7 mmu05012 Parkinson disease Human Diseases 1 0.838001871 Dusp1 mmu05016 Huntington disease Human Diseases 1 0.895165667 Kcnj10 mmu05022 Pathways of neurodegeneration - multiple diseases Human Diseases 2 0.873056957 Fzd4;Fzd7 mmu05031 Amphetamine addiction Human Diseases 1 0.412287917 Fos mmu05132 Salmonella infection Human Diseases 3 0.302905847 Fos;Nfkbia;Tcf7l2 mmu05133 Pertussis Human Diseases 1 0.443272931 Fos mmu05134 Legionellosis Human Diseases 3 0.010702739 Clk1;Clk4;Nfkbia mmu05135 Yersinia infection Human Diseases 3 0.082646758 Fos;Nfkbia;Vav3 mmu05140 Leishmaniasis Human Diseases 2 0.097449565 Fos;Nfkbia mmu05142 Chagas disease Human Diseases 2 0.185859175 Fos;Nfkbia mmu05143 African trypanosomiasis Human Diseases 1 0.247598058 Hbb-bt mmu05144 Malaria Human Diseases 1 0.345135645 Hbb-bt mmu05145 Toxoplasmosis Human Diseases 1 0.56898654 Nfkbia mmu05146 Amoebiasis Human Diseases 1 0.55882251 Col4a5 mmu05160 Hepatitis C Human Diseases 2 0.352248432 Cldn5;Nfkbia mmu05161 Hepatitis B Human Diseases 3 0.128321626 Egr2;Fos;Nfkbia mmu05162 Measles Human Diseases 2 0.298789325 Fos;Nfkbia mmu05163 Human cytomegalovirus infection Human Diseases 2 0.574074953 Cxcl12;Nfkbia mmu05164 Influenza A Human Diseases 1 0.727927394 Nfkbia mmu05165 Human papillomavirus infection Human Diseases 6 0.052627729 Col4a5;Col6a1;Fzd4;Fzd7;Tcf7l2;Tnxb mmu05166 Human T-cell leukemia virus 1 infection Human Diseases 3 0.277751088 Egr2;Fos;Nfkbia mmu05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases 3 0.234414989 Fos;Nfkbia;Tcf7l2 mmu05168 Herpes simplex virus 1 infection Human Diseases 5 0.258374883 Gm6710;Nfkbia;Zfp189;Zfp40;Zfp568 mmu05169 Epstein-Barr virus infection Human Diseases 3 0.242577258 Nfkbia;Sap30;Skp2 mmu05170 Human immunodeficiency virus 1 infection Human Diseases 2 0.537870019 Fos;Nfkbia mmu05171 Coronavirus disease - COVID-19 Human Diseases 2 0.558485796 Fos;Nfkbia mmu05200 Pathways in cancer Human Diseases 11 0.002463566 Col4a5;Cxcl12;Fgf15;Fos;Fzd4;Fzd7;Nfkbia;Ret;Skp2;Tcf7l2;Zbtb16 mmu05202 Transcriptional misregulation in cancer Human Diseases 3 0.228328467 Hmga2;Per2;Zbtb16 mmu05203 Viral carcinogenesis Human Diseases 3 0.242577258 Egr2;Nfkbia;Skp2 mmu05205 Proteoglycans in cancer Human Diseases 4 0.068278552 Fzd4;Fzd7;Kdr;Vav3 mmu05206 MicroRNAs in cancer Human Diseases 4 0.035041348 Ddit4;Hmga2;Igf2bp1;Tnxb mmu05210 Colorectal cancer Human Diseases 2 0.145312361 Fos;Tcf7l2 mmu05213 Endometrial cancer Human Diseases 1 0.360133684 Tcf7l2 mmu05215 Prostate cancer Human Diseases 2 0.174874582 Nfkbia;Tcf7l2 mmu05216 Thyroid cancer Human Diseases 2 0.032273372 Ret;Tcf7l2 mmu05217 Basal cell carcinoma Human Diseases 3 0.012220691 Fzd4;Fzd7;Tcf7l2 mmu05218 Melanoma Human Diseases 1 0.425769831 Fgf15 mmu05220 Chronic myeloid leukemia Human Diseases 1 0.443272931 Nfkbia mmu05221 Acute myeloid leukemia Human Diseases 3 0.0162223 Per2;Tcf7l2;Zbtb16 mmu05222 Small cell lung cancer Human Diseases 3 0.033995371 Col4a5;Nfkbia;Skp2 mmu05223 Non-small cell lung cancer Human Diseases 1 0.425769831 Ret mmu05224 Breast cancer Human Diseases 5 0.005187217 Fgf15;Fos;Fzd4;Fzd7;Tcf7l2 mmu05225 Hepatocellular carcinoma Human Diseases 3 0.145808117 Fzd4;Fzd7;Tcf7l2 mmu05226 Gastric cancer Human Diseases 4 0.026885081 Fgf15;Fzd4;Fzd7;Tcf7l2 mmu05230 Central carbon metabolism in cancer Human Diseases 1 0.412287917 Ret mmu05231 Choline metabolism in cancer Human Diseases 2 0.172145721 Fos;Pla2g4e mmu05235 PD-L1 expression and PD-1 checkpoint pathway in cancer Human Diseases 2 0.145312361 Fos;Nfkbia mmu05323 Rheumatoid arthritis Human Diseases 2 0.140059999 Cxcl12;Fos mmu05412 Arrhythmogenic right ventricular cardiomyopathy Human Diseases 1 0.447565954 Tcf7l2 mmu05417 Lipid and atherosclerosis Human Diseases 3 0.228328467 Fos;Nfkbia;Vav3 mmu05418 Fluid shear stress and atherosclerosis Human Diseases 4 0.025743884 Dusp1;Fos;Kdr;Klf2