{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["de novo MDS","t-MDS only","de novo AML","t-AML only"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"de novo MDS","index":0,"n_rows":29,"n_cols":13,"rows_kept":29,"flags":["formulas_cached_only"]}
["no. ","gender (M1F2)","date of NPC diagnosis","age of diagnosis","diagnosis","alive? (~2023/04)","cause of death","diagnosis to death (mo)","follow-up period (mo)","treatment ","cytogenetic mutation","IPSS-R","prognostic factor"]
[1,1,"2015-08-01",61,"MDS","yes",null,72,72,"Ruxolitinib","JAK2 V617F Mutation",1.5,"Very low "]
[2,1,"2018-09-01",56,"MDS","death 2019/11/24","pneumonia with septic shock",14,14,"Vidaza",null,3.5,"intermediate"]
[3,1,"2011-10-01",62,"MDS","yes",null,123,123,"no (plt transfusion, w/ PD and AML transformation , without treatment)",null,1.5,"Very low "]
[4,1,"2017-10-01",61,"MDS","yes",null,"-- ",78,"no",null,1,"Very low "]
[5,1,"2018-05-01",60,"MDS","yes",null,"-- ",60,"no",null,1.5,"Very low "]
[6,1,"2016 (林新)",66,"MDS","yes",null,"-- ",85,"Etoposiode, Vidaza",null,1.5,"Very low "]
[7,1,"2019-08-01",57,"MDS with leukemic change","death 2020/04/17","Synovitis of knee with septic shock",8,8,"vidaza","JAK2 V617F Mutation",1,"Very low "]
[8,1,"2020-05-01",52,"MDS","yes",null,"-- ",35,"no",null,1.5,"Very low "]
[9,1,"2017-05-01",43,"MDS","death 2019/10/27","spontaneous ICH",17,17,"Vidaza, haplo-allo-HSCT",null,2,"Low  "]
[10,1,"2019-05-20",42,"MDS","death 2021/05/20","respiratory failure",23,23,"Vidaza, haplo-allo-HSCT","39~43,X,-Y,rea(5q),-7,add(11)(p15),-13,add(13)(p11.2),-16,-18,-19,-21,+1~4mar[cp19]/46,XY[1]",7,"Very high"]
[11,1,"2018-09-01",45,"MDS with leukemic change","death 2019/06/15","spontaneous ICH",8,8,"Vidaza",null,3,"Low  "]
[12,1,"2019-05-01",48,"MDS","yes",null,"-- ",47,"no","45,X,-Y[3]/46,XY[17]",0,"Very low "]
[13,2,"2010-04-01",52,"MDS","yes",null,"-- ",90,"no (blood transfusion)",null,2.5,"Low  "]
[14,2,"2008-10-01",51,"MDS","yes",null,"-- ",174,"no (blood transfusion)",null,4,"Intermediate "]
[15,2,"2019-10-01",55,"MDS","death 2020/04/01","spontaneous ICH",6,6,"Vidaza",null,7,"Very high"]
[16,2,"2013-11-01",58,"MDS with CMMoL feature","yes",null,"-- ",113,"Vidaza, haplo-allo-HSCT",null,3.5,"Intermediate "]
[17,2,"2020-03-01",58,"MDS with leukemic change","death 2020/05/20","respiratory failure",2,2,"hydroxyurea",null,3.5,"Intermediate "]
[18,2,"2009-08-01",56,"MDS","yes",null,"-- ",164,"no (blood transfusion)",null,1.5,"Very low "]
[19,2,"2012-11-01",42,"MDS","yes",null,"-- ",125,"no (blood transfusion)",null,2,"Low  "]
[20,2,"2014-04-01",41,"MDS","yes",null,"-- ",108,"Vidaza, haplo-allo-HSCT","no",2.5,"Low  "]
[21,1,"2019-09-01",66,"MDS","yes",null,"-- ",43,"no (blood transfusion)",null,2,"Very low "]
[22,1,"2015-10-01",68,"MDS","yes",null,"-- ",90,"no (blood transfusion)","no",2,"Low  "]
[23,1,"2016-07-01",67,"MDS","yes",null,"-- ",81,"JAKAVI, blood transfusion","JAK2 V617F Mutation, t(11;12)",1,"Very low "]
[24,1,"2019-08-12",68,"MDS","yes",null,"-- ",44,"Vidaza","no",4,"Intermediate "]
[]
["Average all",null,null,55.625,{"$nulls":3},11.14,67.083]
["Average male",null,null,57.62,{"$nulls":3},14,51.75]
["Average female",null,null,51.63,{"$nulls":3},4,97.75]

{"sheet":"t-MDS only","index":1,"n_rows":11,"n_cols":11,"rows_kept":11,"flags":["formulas_cached_only"]}
["no. ","gender (M1F2)","diagnosis","age of NPC diagnosis","Latency of NPC & MN-pCT (y)","alive? (~2023/4)","t-MN to death (mo)","cause of death","treatment ","cytogenetic mutation","IPSS-R"]
[4,2,"t-MDS",48,10,"death",8,"NA","I3A7*2","N/A ","High "]
[5,1,"t-MDS",30,5,"death",25,"pneumonia with respiratory failure","Vidaza*14, Hydrea, I3A7, HiDAC*4","N/A ","Low "]
[6,1,"t-MDS",60,4,"death",0.37,"colitis with septic shock","Vidaza approved but hold ","Rearrangement 6q","High "]
[7,2,"t-MDS",38,3,"death",25,"peumonia with septic shock","Vidaza*7, Hydrea, I2A5","Loss of chromosome 7","Very High"]
[8,1,"t-MDS",61,8,"death",23,"NA","Supportive care","Not detected","Low "]
[9,1,"t-MDS",65,8,"death",2,"peumonia with septic shock","Azacytidine*2","Rearrangement of chromosome 5","Very High"]
[]
["Average all",null,null,50.333333333333336,null,null,13.9]
["Average male",null,null,54,null,null,12.6]
["Average female",null,null,43,null,null,16.5]

{"sheet":"de novo AML","index":2,"n_rows":14,"n_cols":10,"rows_kept":14,"flags":["formulas_cached_only"]}
["no. ","gender (M1F2)","date of diagnosis","age of diagnosis","diagnosis","diagnosis to death (mo)","follow-up period (mo)","treatment ","cytogenetic mutation","IPSS-R"]
[1,1,"2012-11-01",54,"AML",56,56,"I3A7, HiDAC, haplo-identical HSCT","FLT3/ITD(+), NPM1(+)","Intermediate "]
[2,1,"2012-02-29",52,"AML",52,52,"I3A7, HiDAC,FLAG-IDA,Nexavar","FLT3/ITD(+), NPM1(-)","Adverse "]
[3,1,"2013-05-13",55,"AML",6,6,"I3A7, HiDAC, allo-HSCT","FLT3/ITD(-), NPM1(-)","Intermediate"]
[4,1,"2013-05-13",57,"AML","--",119,"I3A7, HiDAC, allo-HSCT","FLT3/ITD(+), NPM1(-)","Adverse "]
[5,1,"2014-10-16",54,"AML","--",102,"I3A7, HiDAC, haplo-identical HSCT","FLT3/ITD(-), NPM1(-)","Intermediate"]
[6,1,"2007-10-31",55,"AML",1,1,"I2A5, HiDAC","AML M2 type","Intermediate"]
[7,1,"2005-09-22",50,"AML","--",212,"HiDAC, Auto-PBSCT ","AML M4 type","Intermediate"]
[8,1,"2008-12-03",54,"AML",5,5,"I3A7, HIDAC, Hydrea","AML M1 or 2 type","Intermediate"]
[9,1,"2006-04-04",81,"AML",4,4,"Hydrea","AML M4 type","Intermediate"]
[10,1,"2012-05-30",82,"AML",5,5,"no (blood transfusion)","46,XY,del(5)(q12q33)","Adverse "]
[11,1,"2006-01-06",82,"AML",0.17,0.17,"Hydrea","AML M2 type","Intermediate"]
[12,1,"2007-11-07",77,"AML",4,4,"Hydrea","AML M2 type","Intermediate"]
["Average all",null,null,62.75,null,14.8,47.18083333333333]

{"sheet":"t-AML only","index":3,"n_rows":4,"n_cols":10,"rows_kept":4,"flags":["formulas_cached_only"]}
["no. ","gender (M1F2)","diagnosis","age of NPC diagnosis","Latency of NPC & MN-pCT (y)","alive? (~2023/4)","t-MN to death (mo)","treatment ","cytogenetic mutation","ELN risk stratification "]
[1,1,"t-AML",51,9,"death",1,"Vincristine , prednisolone","FLT3/ITD (+)","Adverse "]
[2,1,"t-AML",53,5,"death",1,"I3A7*1 ","TP53 (+), Deletion 7q ","Adverse"]
[3,1,"t-AML",78,7,"death",1,"Supportive care","Deletion 5,rea(7q)","Adverse"]