The potential substrates targeted by the risk-related E3RGs					
Species	SUBGENE	E3GENE	SOURCE	SOURCEID	SENTENCE
H.sapiens	DYNC1I1	TRIM58	MEDLINE	25241935	UbiNet 2.0
H.sapiens	DYNC1LI2	TRIM58	MEDLINE	22199232	E3Net
H.sapiens	TAB3	RBCK1	MEDLINE	17449468	<span class="match term0">RBCK1</span> negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.
H.sapiens	IRF3	RBCK1	MEDLINE	18711448	"Furthermore, viral infection leads to induction of <span class=""match term0"">RBCK1</span> and subsequent degradation of <span class=""match term1"">IRF3</span>"
H.sapiens	TRIM25	RBCK1	MEDLINE	21292167	UbiNet 2.0
H.sapiens	RIPK1	RBCK1	MEDLINE	22199232	E3Net
H.sapiens	PRKCA	RBCK1	MEDLINE	25118570	UbiNet 2.0
H.sapiens	TAB2	RBCK1	MEDLINE	17449468	<span class="match term0">RBCK1</span> negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting <span class="match term1">TAB2</span>/3 for degradation
H.sapiens	IREB2	RBCK1	MEDLINE	16275334	"Through studies analyzing iron-mediated degradation of iron regulatory protein 2 (<span class=""match term1"">IRP2</span>), a central regulator of iron metabolism in mammalian cells, we have identified a RING finger protein, <span class=""match term0"">HOIL-1</span>, as an ubiquitin ligase recognizing <span class=""match term1"">IRP2</span> through a signal created by heme-mediated oxidative modification of the protein"
H.sapiens	RBCK1	RBCK1	MEDLINE	18303026	UbiNet 2.0
H.sapiens	BACH1	RBCK1	MEDLINE	17682061	UbiNet 2.0
H.sapiens	IKBKG	RBCK1	MEDLINE	19675569	UbiNet 2.0
H.sapiens	NR1I2	RBCK1	MEDLINE	23160820	UbiNet 2.0