The KEGG enrichment analysis of the differentially risk-related DEGs ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count hsa04916 hsa04916 Melanogenesis 6/75 101/8189 0.000306964 0.051876998 0.043944389 7475/80326/8326/1638/816/810 6 hsa04966 hsa04966 Collecting duct acid secretion 3/75 27/8189 0.001842905 0.135935431 0.115149291 525/50617/495 3 hsa04974 hsa04974 Protein digestion and absorption 5/75 103/8189 0.00245486 0.135935431 0.115149291 486/1280/136227/57642/1302 5 hsa04720 hsa04720 Long-term potentiation 4/75 67/8189 0.003217407 0.135935431 0.115149291 5502/2905/816/810 4 hsa04721 hsa04721 Synaptic vesicle cycle 4/75 78/8189 0.005552155 0.154882351 0.131199002 6530/774/525/50617 4 hsa04080 hsa04080 Neuroactive ligand-receptor interaction 9/75 362/8189 0.005556604 0.154882351 0.131199002 7425/9127/5020/4985/283869/3972/2905/2797/796 9 hsa04728 hsa04728 Dopaminergic synapse 5/75 132/8189 0.007069344 0.154882351 0.131199002 2792/816/50632/810/774 5 hsa04976 hsa04976 Bile secretion 4/75 89/8189 0.008814239 0.154882351 0.131199002 6822/6579/486/343 4 hsa04550 hsa04550 Signaling pathways regulating pluripotency of stem cells 5/75 143/8189 0.009821608 0.154882351 0.131199002 7475/80326/8326/2103/1852 5 hsa04912 hsa04912 GnRH signaling pathway 4/75 93/8189 0.010255985 0.154882351 0.131199002 3972/2797/816/810 4 hsa05224 hsa05224 Breast cancer 5/75 147/8189 0.010983269 0.154882351 0.131199002 7475/80326/8326/9965/10683 5 hsa04713 hsa04713 Circadian entrainment 4/75 97/8189 0.011842876 0.154882351 0.131199002 2905/2792/816/810 4 hsa04261 hsa04261 Adrenergic signaling in cardiomyocytes 5/75 150/8189 0.011914027 0.154882351 0.131199002 6331/5502/486/816/810 5 hsa04934 hsa04934 Cushing syndrome 5/75 155/8189 0.013582535 0.158445995 0.134217723 7475/80326/8326/1029/816 5 hsa04024 hsa04024 cAMP signaling pathway 6/75 221/8189 0.015470254 0.158445995 0.134217723 5020/3972/2905/486/816/810 6 hsa04964 hsa04964 Proximal tubule bicarbonate reclamation 2/75 23/8189 0.018492308 0.158445995 0.134217723 10991/486 2 hsa05225 hsa05225 Hepatocellular carcinoma 5/75 168/8189 0.018643777 0.158445995 0.134217723 7475/80326/3481/8326/1029 5 hsa04310 hsa04310 Wnt signaling pathway 5/75 170/8189 0.019519378 0.158445995 0.134217723 7475/80326/343637/8326/816 5 hsa04725 hsa04725 Cholinergic synapse 4/75 113/8189 0.019735827 0.158445995 0.134217723 3785/2792/816/774 4 hsa05217 hsa05217 Basal cell carcinoma 3/75 63/8189 0.019786882 0.158445995 0.134217723 7475/80326/8326 3 hsa04977 hsa04977 Vitamin digestion and absorption 2/75 24/8189 0.02005519 0.158445995 0.134217723 9227/338 2 hsa04929 hsa04929 GnRH secretion 3/75 64/8189 0.020626106 0.158445995 0.134217723 3972/3780/2797 3 hsa04020 hsa04020 Calcium signaling pathway 6/75 240/8189 0.02228406 0.163739395 0.138701699 9127/2905/9965/816/810/774 6 hsa05031 hsa05031 Amphetamine addiction 3/75 69/8189 0.025113299 0.176839478 0.149798624 2905/816/810 3 hsa04744 hsa04744 Phototransduction 2/75 29/8189 0.028648765 0.187701276 0.158999523 2792/810 2 hsa05022 hsa05022 Pathways of neurodegeneration - multiple diseases 9/75 476/8189 0.029051522 0.187701276 0.158999523 7475/80326/7345/112714/2905/8326/816/810/774 9 hsa05214 hsa05214 Glioma 3/75 75/8189 0.031137529 0.187701276 0.158999523 1029/816/810 3 hsa05165 hsa05165 Human papillomavirus infection 7/75 331/8189 0.031302063 0.187701276 0.158999523 7475/80326/84667/8326/1280/525/50617 7 hsa04971 hsa04971 Gastric acid secretion 3/75 76/8189 0.032209095 0.187701276 0.158999523 816/810/495 3 hsa05205 hsa05205 Proteoglycans in cancer 5/75 205/8189 0.039396587 0.221934107 0.187997748 7475/80326/3481/8326/816 5 hsa04911 hsa04911 Insulin secretion 3/75 86/8189 0.043971384 0.239714964 0.203059702 3780/486/816 3 hsa05226 hsa05226 Gastric cancer 4/75 149/8189 0.04738384 0.242322035 0.205268121 7475/80326/8326/9965 4 hsa04727 hsa04727 GABAergic synapse 3/75 89/8189 0.047865121 0.242322035 0.205268121 10991/2792/774 3 hsa04145 hsa04145 Phagosome 4/75 152/8189 0.050332381 0.242322035 0.205268121 112714/6441/525/50617 4 hsa00260 hsa00260 "Glycine, serine and threonine metabolism" 2/75 40/8189 0.051618895 0.242322035 0.205268121 875/635 2 hsa05033 hsa05033 Nicotine addiction 2/75 40/8189 0.051618895 0.242322035 0.205268121 2905/774 2 hsa04150 hsa04150 mTOR signaling pathway 4/75 156/8189 0.054418462 0.248560002 0.210552229 7475/80326/8326/525 4 hsa04070 hsa04070 Phosphatidylinositol signaling system 3/75 97/8189 0.059046004 0.26226792 0.222164043 139189/1607/810 3 hsa04750 hsa04750 Inflammatory mediator regulation of TRP channels 3/75 98/8189 0.060523366 0.26226792 0.222164043 816/810/55515 3 hsa05110 hsa05110 Vibrio cholerae infection 2/75 50/8189 0.076508248 0.318577922 0.269863578 525/50617 2 hsa00270 hsa00270 Cysteine and methionine metabolism 2/75 51/8189 0.079173211 0.318577922 0.269863578 875/635 2 hsa04979 hsa04979 Cholesterol metabolism 2/75 51/8189 0.079173211 0.318577922 0.269863578 4036/338 2 hsa04724 hsa04724 Glutamatergic synapse 3/75 114/8189 0.086438255 0.339722442 0.28777485 10991/2905/2792 3 hsa04978 hsa04978 Mineral absorption 2/75 60/8189 0.104372964 0.400887064 0.339586676 7018/486 2 hsa00561 hsa00561 Glycerolipid metabolism 2/75 62/8189 0.110239488 0.41401052 0.350703399 139189/1607 2 hsa00190 hsa00190 Oxidative phosphorylation 3/75 134/8189 0.124253161 0.453566005 0.384210381 525/50617/495 3 hsa00603 hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/75 15/8189 0.129015451 0.453566005 0.384210381 10317 1 hsa04924 hsa04924 Renin secretion 2/75 69/8189 0.131413865 0.453566005 0.384210381 22802/810 2 hsa05120 hsa05120 Epithelial cell signaling in Helicobacter pylori infection 2/75 70/8189 0.134512244 0.453566005 0.384210381 525/50617 2 hsa05010 hsa05010 Alzheimer disease 6/75 384/8189 0.138886417 0.453566005 0.384210381 7475/80326/112714/2905/8326/810 6 hsa05218 hsa05218 Melanoma 2/75 72/8189 0.140758376 0.453566005 0.384210381 9965/1029 2 hsa04115 hsa04115 p53 signaling pathway 2/75 73/8189 0.143905031 0.453566005 0.384210381 56475/1029 2 hsa00120 hsa00120 Primary bile acid biosynthesis 1/75 17/8189 0.144926416 0.453566005 0.384210381 1109 1 hsa00910 hsa00910 Nitrogen metabolism 1/75 17/8189 0.144926416 0.453566005 0.384210381 765 1 hsa04918 hsa04918 Thyroid hormone synthesis 2/75 75/8189 0.150242834 0.461655254 0.391062688 4036/486 2 hsa04921 hsa04921 Oxytocin signaling pathway 3/75 154/8189 0.166968378 0.495139336 0.419426657 5020/816/810 3 hsa00670 hsa00670 One carbon pool by folate 1/75 20/8189 0.168256612 0.495139336 0.419426657 10841 1 hsa04014 hsa04014 Ras signaling pathway 4/75 236/8189 0.169929476 0.495139336 0.419426657 3481/2792/9965/810 4 hsa04390 hsa04390 Hippo signaling pathway 3/75 157/8189 0.17372068 0.495431641 0.419674264 7475/80326/8326 3 hsa00770 hsa00770 Pantothenate and CoA biosynthesis 1/75 21/8189 0.17589289 0.495431641 0.419674264 8876 1 hsa00340 hsa00340 Histidine metabolism 1/75 22/8189 0.183459985 0.506980874 0.429457483 10841 1 hsa04742 hsa04742 Taste transduction 2/75 86/8189 0.185992983 0.506980874 0.429457483 6326/255022 2 hsa00515 hsa00515 Mannose type O-glycan biosynthesis 1/75 23/8189 0.190958516 0.512253797 0.433924114 146664 1 hsa04022 hsa04022 cGMP-PKG signaling pathway 3/75 167/8189 0.196766476 0.519586474 0.440135537 4985/486/810 3 hsa05032 hsa05032 Morphine addiction 2/75 91/8189 0.20262991 0.524303255 0.444131066 2792/774 2 hsa04970 hsa04970 Salivary secretion 2/75 92/8189 0.205978942 0.524303255 0.444131066 486/810 2 hsa05323 hsa05323 Rheumatoid arthritis 2/75 93/8189 0.209334251 0.524303255 0.444131066 525/50617 2 hsa00601 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 1/75 27/8189 0.220279174 0.524303255 0.444131066 10317 1 hsa01522 hsa01522 Endocrine resistance 2/75 98/8189 0.226191553 0.524303255 0.444131066 10683/1029 2 hsa04925 hsa04925 Aldosterone synthesis and secretion 2/75 98/8189 0.226191553 0.524303255 0.444131066 816/810 2 hsa05231 hsa05231 Choline metabolism in cancer 2/75 98/8189 0.226191553 0.524303255 0.444131066 139189/1607 2 hsa05012 hsa05012 Parkinson disease 4/75 266/8189 0.226286667 0.524303255 0.444131066 7345/112714/816/810 4 hsa05152 hsa05152 Tuberculosis 3/75 180/8189 0.227766421 0.524303255 0.444131066 816/810/50617 3 hsa00564 hsa00564 Glycerophospholipid metabolism 2/75 99/8189 0.229576573 0.524303255 0.444131066 139189/1607 2 hsa04972 hsa04972 Pancreatic secretion 2/75 102/8189 0.239752363 0.530219373 0.44914254 486/22802 2 hsa00030 hsa00030 Pentose phosphate pathway 1/75 30/8189 0.241579241 0.530219373 0.44914254 9104 1 hsa00053 hsa00053 Ascorbate and aldarate metabolism 1/75 30/8189 0.241579241 0.530219373 0.44914254 9104 1 hsa05034 hsa05034 Alcoholism 3/75 187/8189 0.244842555 0.530492203 0.44937365 2905/2792/810 3 hsa04922 hsa04922 Glucagon signaling pathway 2/75 107/8189 0.256761051 0.549273642 0.465283184 816/810 2 hsa05167 hsa05167 Kaposi sarcoma-associated herpesvirus infection 3/75 194/8189 0.262125092 0.549926522 0.465836231 2792/344807/810 3 hsa04066 hsa04066 HIF-1 signaling pathway 2/75 109/8189 0.26357425 0.549926522 0.465836231 7018/816 2 hsa00350 hsa00350 Tyrosine metabolism 1/75 36/8189 0.282471706 0.568060678 0.48119746 1638 1 hsa04010 hsa04010 MAPK signaling pathway 4/75 294/8189 0.282652794 0.568060678 0.48119746 3481/9965/1852/774 4 hsa04726 hsa04726 Serotonergic synapse 2/75 115/8189 0.284016266 0.568060678 0.48119746 2792/774 2 hsa00250 hsa00250 "Alanine, aspartate and glutamate metabolism" 1/75 37/8189 0.289072298 0.568060678 0.48119746 339983 1 hsa04960 hsa04960 Aldosterone-regulated sodium reabsorption 1/75 37/8189 0.289072298 0.568060678 0.48119746 486 1 hsa04722 hsa04722 Neurotrophin signaling pathway 2/75 119/8189 0.297624249 0.578143657 0.489738632 816/810 2 hsa05417 hsa05417 Lipid and atherosclerosis 3/75 215/8189 0.314759575 0.591276235 0.500863083 816/810/338 3 hsa04216 hsa04216 Ferroptosis 1/75 41/8189 0.314880835 0.591276235 0.500863083 7018 1 hsa05219 hsa05219 Bladder cancer 1/75 41/8189 0.314880835 0.591276235 0.500863083 1029 1 hsa04940 hsa04940 Type I diabetes mellitus 1/75 43/8189 0.327436205 0.601486072 0.509511714 5798 1 hsa04975 hsa04975 Fat digestion and absorption 1/75 43/8189 0.327436205 0.601486072 0.509511714 338 1 hsa04114 hsa04114 Oocyte meiosis 2/75 131/8189 0.338178115 0.611275532 0.51780425 816/810 2 hsa05163 hsa05163 Human cytomegalovirus infection 3/75 225/8189 0.339999409 0.611275532 0.51780425 2792/1029/810 3 hsa04930 hsa04930 Type II diabetes mellitus 1/75 46/8189 0.345844762 0.613015805 0.519278415 774 1 hsa04270 hsa04270 Vascular smooth muscle contraction 2/75 134/8189 0.348221996 0.613015805 0.519278415 810/796 2 hsa04973 hsa04973 Carbohydrate digestion and absorption 1/75 47/8189 0.35186977 0.613051456 0.519308614 486 1 hsa05030 hsa05030 Cocaine addiction 1/75 49/8189 0.363756 0.622827646 0.527589909 2905 1 hsa04371 hsa04371 Apelin signaling pathway 2/75 139/8189 0.364851698 0.622827646 0.527589909 2792/810 2 hsa00510 hsa00510 N-Glycan biosynthesis 1/75 50/8189 0.369618199 0.624654756 0.529137632 146664 1 hsa04913 hsa04913 Ovarian steroidogenesis 1/75 51/8189 0.375427099 0.628189898 0.532132209 3972 1 hsa04961 hsa04961 Endocrine and other factor-regulated calcium reabsorption 1/75 53/8189 0.386886909 0.640864722 0.542868901 486 1 hsa04072 hsa04072 Phospholipase D signaling pathway 2/75 148/8189 0.39437829 0.640864722 0.542868901 139189/1607 2 hsa04723 hsa04723 Retrograde endocannabinoid signaling 2/75 148/8189 0.39437829 0.640864722 0.542868901 2792/774 2 hsa04340 hsa04340 Hedgehog signaling pathway 1/75 56/8189 0.403688695 0.646287103 0.547462137 4036 1 hsa04151 hsa04151 PI3K-Akt signaling pathway 4/75 354/8189 0.408225269 0.646287103 0.547462137 3481/2792/9965/1280 4 hsa05134 hsa05134 Legionellosis 1/75 57/8189 0.409187693 0.646287103 0.547462137 1917 1 hsa04330 hsa04330 Notch signaling pathway 1/75 59/8189 0.420036017 0.651365578 0.551764052 10683 1 hsa04218 hsa04218 Cellular senescence 2/75 156/8189 0.420111527 0.651365578 0.551764052 1029/810 2 hsa00140 hsa00140 Steroid hormone biosynthesis 1/75 62/8189 0.435941006 0.669763909 0.56734906 1109 1 hsa05020 hsa05020 Prion disease 3/75 273/8189 0.458997653 0.69521455 0.588907997 112714/2905/774 3 hsa04530 hsa04530 Tight junction 2/75 169/8189 0.460733903 0.69521455 0.588907997 112714/9074 2 hsa00830 hsa00830 Retinol metabolism 1/75 68/8189 0.466470917 0.697642345 0.590964553 9227 1 hsa05204 hsa05204 Chemical carcinogenesis - DNA adducts 1/75 69/8189 0.471398227 0.698827196 0.591968226 6822 1 hsa04917 hsa04917 Prolactin signaling pathway 1/75 70/8189 0.476280632 0.699070496 0.592174323 3972 1 hsa05223 hsa05223 Non-small cell lung cancer 1/75 72/8189 0.485912343 0.699070496 0.592174323 1029 1 hsa01524 hsa01524 Platinum drug resistance 1/75 73/8189 0.490662444 0.699070496 0.592174323 1029 1 hsa04360 hsa04360 Axon guidance 2/75 182/8189 0.499700198 0.699070496 0.592174323 6585/816 2 hsa01230 hsa01230 Biosynthesis of amino acids 1/75 75/8189 0.500033106 0.699070496 0.592174323 875 1 hsa05133 hsa05133 Pertussis 1/75 76/8189 0.504654441 0.699070496 0.592174323 810 1 hsa05212 hsa05212 Pancreatic cancer 1/75 76/8189 0.504654441 0.699070496 0.592174323 1029 1 hsa05220 hsa05220 Chronic myeloid leukemia 1/75 76/8189 0.504654441 0.699070496 0.592174323 1029 1 hsa05140 hsa05140 Leishmaniasis 1/75 77/8189 0.509233625 0.69967872 0.592689542 1917 1 hsa00980 hsa00980 Metabolism of xenobiotics by cytochrome P450 1/75 78/8189 0.513771036 0.700220202 0.593148225 6822 1 hsa05130 hsa05130 Pathogenic Escherichia coli infection 2/75 197/8189 0.542415157 0.724007353 0.613298038 112714/9074 2 hsa04012 hsa04012 ErbB signaling pathway 1/75 85/8189 0.544394443 0.724007353 0.613298038 816 1 hsa04610 hsa04610 Complement and coagulation cascades 1/75 86/8189 0.548610931 0.724007353 0.613298038 2266 1 hsa04260 hsa04260 Cardiac muscle contraction 1/75 87/8189 0.552788912 0.724007353 0.613298038 486 1 hsa04512 hsa04512 ECM-receptor interaction 1/75 88/8189 0.556928733 0.724007353 0.613298038 1280 1 hsa04540 hsa04540 Gap junction 1/75 88/8189 0.556928733 0.724007353 0.613298038 112714 1 hsa04658 hsa04658 Th1 and Th2 cell differentiation 1/75 92/8189 0.573113252 0.734764476 0.622410269 10683 1 hsa04015 hsa04015 Rap1 signaling pathway 2/75 210/8189 0.577386561 0.734764476 0.622410269 9965/810 2 hsa05170 hsa05170 Human immunodeficiency virus 1 infection 2/75 212/8189 0.582594318 0.734764476 0.622410269 2792/810 2 hsa05207 hsa05207 Chemical carcinogenesis - receptor activation 2/75 212/8189 0.582594318 0.734764476 0.622410269 10683/774 2 hsa05150 hsa05150 Staphylococcus aureus infection 1/75 96/8189 0.588714179 0.736300287 0.623711237 2266 1 hsa05215 hsa05215 Prostate cancer 1/75 97/8189 0.592525675 0.736300287 0.623711237 3645 1 hsa04810 hsa04810 Regulation of actin cytoskeleton 2/75 218/8189 0.597939543 0.737604254 0.624815812 3645/9965 2 hsa04625 hsa04625 C-type lectin receptor signaling pathway 1/75 104/8189 0.618247609 0.757129318 0.641355262 810 1 hsa03013 hsa03013 Nucleocytoplasmic transport 1/75 108/8189 0.632219487 0.768669736 0.651131012 1917 1 hsa04670 hsa04670 Leukocyte transendothelial migration 1/75 114/8189 0.652236472 0.785630029 0.665497875 9074 1 hsa01200 hsa01200 Carbon metabolism 1/75 115/8189 0.655466474 0.785630029 0.665497875 9104 1 hsa04071 hsa04071 Sphingolipid signaling pathway 1/75 119/8189 0.668093109 0.795124897 0.673540866 4985 1 hsa04919 hsa04919 Thyroid hormone signaling pathway 1/75 121/8189 0.674234093 0.79682211 0.674978555 486 1 hsa04611 hsa04611 Platelet activation 1/75 124/8189 0.683235951 0.801853304 0.679240419 2266 1 hsa04110 hsa04110 Cell cycle 1/75 126/8189 0.689100377 0.80315837 0.680345926 1029 1 hsa04926 hsa04926 Relaxin signaling pathway 1/75 129/8189 0.697696715 0.807607841 0.684115019 2792 1 hsa04142 hsa04142 Lysosome 1/75 132/8189 0.706058447 0.811079105 0.687055486 50617 1 hsa04210 hsa04210 Apoptosis 1/75 136/8189 0.716853379 0.811079105 0.687055486 112714 1 hsa04910 hsa04910 Insulin signaling pathway 1/75 137/8189 0.719490408 0.811079105 0.687055486 810 1 hsa04915 hsa04915 Estrogen signaling pathway 1/75 138/8189 0.722103202 0.811079105 0.687055486 810 1 hsa05418 hsa05418 Fluid shear stress and atherosclerosis 1/75 139/8189 0.724691981 0.811079105 0.687055486 810 1 hsa05017 hsa05017 Spinocerebellar ataxia 1/75 143/8189 0.734811271 0.816994111 0.692066017 2905 1 hsa01240 hsa01240 Biosynthesis of cofactors 1/75 153/8189 0.75853177 0.83590566 0.708085766 9104 1 hsa04514 hsa04514 Cell adhesion molecules 1/75 157/8189 0.767422485 0.83590566 0.708085766 9074 1 hsa05160 hsa05160 Hepatitis C 1/75 157/8189 0.767422485 0.83590566 0.708085766 9074 1 hsa04217 hsa04217 Necroptosis 1/75 159/8189 0.771745929 0.83590566 0.708085766 816 1 hsa05016 hsa05016 Huntington disease 2/75 306/8189 0.776551412 0.83590566 0.708085766 112714/774 2 hsa05206 hsa05206 MicroRNAs in cancer 2/75 310/8189 0.782755201 0.837250816 0.709225232 131405/1029 2 hsa04613 hsa04613 Neutrophil extracellular trap formation 1/75 190/8189 0.829452789 0.878954731 0.744552123 2266 1 hsa04062 hsa04062 Chemokine signaling pathway 1/75 192/8189 0.832636154 0.878954731 0.744552123 2792 1 hsa04510 hsa04510 Focal adhesion 1/75 201/8189 0.846250822 0.878954731 0.744552123 1280 1 hsa05415 hsa05415 Diabetic cardiomyopathy 1/75 203/8189 0.849124575 0.878954731 0.744552123 816 1 hsa05203 hsa05203 Viral carcinogenesis 1/75 204/8189 0.850541511 0.878954731 0.744552123 1029 1 hsa05014 hsa05014 Amyotrophic lateral sclerosis 2/75 364/8189 0.852950153 0.878954731 0.744552123 112714/2905 2 hsa05166 hsa05166 Human T-cell leukemia virus 1 infection 1/75 222/8189 0.873913177 0.8909152 0.754683694 1029 1 hsa05208 hsa05208 Chemical carcinogenesis - reactive oxygen species 1/75 223/8189 0.875100137 0.8909152 0.754683694 1109 1 hsa05171 hsa05171 Coronavirus disease - COVID-19 1/75 232/8189 0.885298534 0.895900912 0.758907032 2266 1 hsa05132 hsa05132 Salmonella infection 1/75 249/8189 0.902371084 0.90774234 0.768937765 112714 1 hsa04740 hsa04740 Olfactory transduction 2/75 439/8189 0.916761289 0.916761289 0.77657761 816/810 2