﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU YESAVAGE, JA
AF YESAVAGE, JA
TI TECHNIQUES FOR COGNITIVE TRAINING OF MEMORY IN AGE-ASSOCIATED MEMORY
   IMPAIRMENT
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
RP YESAVAGE, JA (corresponding author), STANFORD UNIV,VET ADM MED CTR,SCH MED,GERIATR PSYCHIAT CLIN RES CTR,STANFORD,CA 94305, USA.
CR [Anonymous], HDB PSYCHOL AGING
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NR 9
TC 8
Z9 9
U1 0
U2 3
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0167-4943
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PY 1989
SU 1
BP 185
EP 190
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA U5681
UT WOS:A1989U568100015
PM 2757731
DA 2023-08-17
ER

PT J
AU McPhee, GM
   Downey, LA
   Noble, A
   Stough, C
AF McPhee, Grace M.
   Downey, Luke A.
   Noble, Anthony
   Stough, Con
TI Cognitive training and Bacopa monnieri: Evidence for a combined
   intervention to alleviate age associated cognitive decline
SO MEDICAL HYPOTHESES
LA English
DT Article
ID PROTEIN-KINASE-II; ELEMENT-BINDING PROTEIN; HEALTHY OLDER-ADULTS; NERVE
   GROWTH-FACTOR; QUALITY-OF-LIFE; NF-KAPPA-B; DOUBLE-BLIND;
   HIPPOCAMPAL-NEURONS; MEMORY COMPLAINTS; WORKING-MEMORY
AB As the elderly population grows the impact of age associated cognitive decline as well as neurodegenerative diseases such as Alzheimer's disease and dementia will increase. Ageing is associated with consistent impairments in cognitive processes (e.g., processing speed, memory, executive function and learning) important for work, well-being, life satisfaction and overall participation in society. Recently, there has been increased effort to conduct research examining methods to improve cognitive function in older citizens. Cognitive training has been shown to improve performance in some cognitive domains; including memory, processing speed, executive function and attention in older adults. These cognitive changes are thought to be related to improvements in brain connectivity and neural circuitry. Bacopa monnieri has also been shown to improve specific domains of cognition, sensitive to age associated cognitive decline (particularly processing speed and memory). These Bacopa monnieri dependent improvements may be due to the increase in specific neuro-molecular mechanisms implicated in the enhancement of neural connections in the brain (i.e. synaptogenesis). in particular, a number of animal studies have shown Bacopa monnieri consumption upregulates calcium dependent kinases in the synapse and post-synaptic cell, crucial for strengthening and growing connections between neurons. These effects have been shown to occur in areas important for cognitive processes, such as the hippocampus. As Bacopa monnieri has shown neuro-molecular mechanisms that encourage synaptogenesis, while cognitive training enhances brain connectivity, Bacopa monnieri supplementation could theoretically enhance and strengthen synaptic changes acquired through cognitive training. Therefore, the current paper hypothesises that the combination of these two interventions could improve cognitive outcomes, over and above the effects of administrating these interventions independently, as an effective treatment to ameliorate age associated cognitive decline. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [McPhee, Grace M.; Downey, Luke A.; Stough, Con] Swinburne Univ Technol, Ctr Human Psychopharmacol, Melbourne, Vic, Australia.
   [Downey, Luke A.] Austin Hlth, Inst Breathing & Sleep, Melbourne, Vic, Australia.
   [Noble, Anthony] SFI Res Pty Ltd, Level 4,156 Pacific Highway, St Leonards, NSW 2065, Australia.
C3 Swinburne University of Technology; Austin Research Institute; Florey
   Institute of Neuroscience & Mental Health; Institute for Breathing &
   Sleep (IBAS)
RP Stough, C (corresponding author), Swinburne Univ Technol, Ctr Human Psychopharmacol, POB 218, Hawthorn, Vic 3122, Australia.
EM Anthony.Noble@sfihealth.com; cstough@swin.edu.au
RI Downey, Luke/AAG-8854-2020
OI Downey, Luke/0000-0001-5670-3192
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NR 83
TC 3
Z9 3
U1 0
U2 18
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD OCT
PY 2016
VL 95
BP 71
EP 76
DI 10.1016/j.mehy.2016.09.002
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DY7RB
UT WOS:000385325900017
PM 27692172
DA 2023-08-17
ER

PT J
AU Liu, XY
   Li, L
   Xiao, JQ
   He, CZ
   Lyu, XL
   Gao, L
   Yang, XW
   Cui, XG
   Fan, LH
AF Liu Xin Yan
   Li Li
   Xiao Jia Qing
   He Chang Zhi
   Lyu Xiu Lin
   Gao Lei
   Yang Xiao Wei
   Cui Xin Gang
   Fan Li Hua
TI Cognitive Training in Older Adults with Mild Cognitive Impairment
SO BIOMEDICAL AND ENVIRONMENTAL SCIENCES
LA English
DT Article
DE Older adults; Rural; Mild cognitive impairment; Cognitive training;
   Efficacy
ID ASSESSMENT LOTCA; INTERVENTIONS; PERFORMANCE; MCI; REHABILITATION;
   DEMENTIA; IMPACT
AB Objective We investigated the feasibility and efficacy of cognitive training for older adults in rural settings and with low education levels, who have mild cognitive impairment (MCI).
   Methods Forty-five older adults (ages >65 years) with MCI were assigned to treatment or control groups, at a 2:1 ratio. Cognitive training occurred in the treatment group for 2 months. The cognitive abilities of the participants were assessed at pre-training, metaphase, and post-training time points, using the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Loewenstein Occupational Therapy Cognitive Assessment (LOTCA), and Hamilton Depression Scale (HAM-D).
   Results Following training, cognitive abilities improved in the treatment group, based on the total scores of all 4 measures, as well as specifically on the MoCA and LOTCA. There were differences in the main effects of group and time point on some subscales, but these differences had little, if any, effect on the overall analyses.
   Conclusion The present study demonstrated that cognitive training has beneficial effects on attention, language, orientation, visual perception, organization of visual movement, and logical questioning in patients with MCI. Furthermore, the observed effects are long-term changes.
C1 [Liu Xin Yan; Li Li; Gao Lei; Fan Li Hua] Harbin Med Univ, Coll Publ Hlth, Harbin 150086, Heilongjiang, Peoples R China.
   [Xiao Jia Qing] Heilongjiang Prov Ctr Dis Control & Prevent, Harbin 150040, Heilongjiang, Peoples R China.
   [He Chang Zhi] Harbin Med Univ, Coll Management Postgrad, Harbin 150086, Heilongjiang, Peoples R China.
   [Lyu Xiu Lin] Heilongjiang Prov Hosp, Harbin 150040, Heilongjiang, Peoples R China.
   [Yang Xiao Wei; Cui Xin Gang] Mudanjiang Med Coll, Dept Publ Hlth, Mudanjiang 157000, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Mudanjiang Medical
   University
RP Fan, LH (corresponding author), Harbin Med Univ, Coll Publ Hlth, Harbin 150086, Heilongjiang, Peoples R China.
EM lihuafan2012@163.com
FU Department of Health, Heilongjiang Province, China
FX This work was supported by the Department of Health, Heilongjiang
   Province, China. The authors thank the Department of Health,
   Heilongjiang Province for this support. The authors also thank Chunjie
   Dai (nurse at the health center in Si Duan village), Yuwen Zou
   (teacher), and Shulin Wang (director of the health center in Si Duan
   village) for their contributions to this work.
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NR 36
TC 17
Z9 18
U1 7
U2 45
PU CHINESE CENTER DISEASE CONTROL & PREVENTION
PI BEIJING
PA 155 CHANGBAI RD, CHANGPING DISTRICT, BEIJING, 102206, PEOPLES R CHINA
SN 0895-3988
J9 BIOMED ENVIRON SCI
JI Biomed. Environ. Sci.
PD MAY
PY 2016
VL 29
IS 5
BP 356
EP 364
DI 10.3967/bes2016.046
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA DV4OU
UT WOS:000382905700006
PM 27353710
DA 2023-08-17
ER

PT J
AU Lee, JY
AF Lee, Jun-Young
TI Memory training with metamemory concept in mild cognitive impairment and
   healthy elders
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Meeting Abstract
C1 [Lee, Jun-Young] Seoul Natl Univ, Seoul 151, South Korea.
C3 Seoul National University (SNU)
NR 0
TC 0
Z9 0
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD OCT
PY 2013
VL 25
SU 1
MA SY03-02
BP S13
EP S13
PG 1
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA AJ5UB
UT WOS:000337753100028
DA 2023-08-17
ER

PT J
AU Mudar, R
   Chiang, HS
   Eroh, J
   Rackley, A
   Venza, E
   Martin-Cook, K
   Womack, K
   Hart, J
   Chapman, S
AF Mudar, Raksha
   Chiang, Hsueh-Sheng
   Eroh, Justin
   Rackley, Audette
   Venza, Erin
   Martin-Cook, Kristin
   Womack, Kyle
   Hart, John, Jr.
   Chapman, Sandra
TI BENEFITS OF COGNITIVE TRAINING IN INDIVIDUALS WITH MILD COGNITIVE
   IMPAIRMENT
SO JOURNAL OF COGNITIVE NEUROSCIENCE
LA English
DT Meeting Abstract
CT 20th Annual Meeting of the Cognitive-Neuroscience-Society
CY APR 13-16, 2013
CL San Francisco, CA
SP Cognit Neuroscience Soc
C1 [Mudar, Raksha] Univ Illinois, Urbana, IL 61801 USA.
   [Mudar, Raksha; Chiang, Hsueh-Sheng; Eroh, Justin; Rackley, Audette; Venza, Erin; Hart, John, Jr.; Chapman, Sandra] Univ Texas Dallas, Dallas, TX 75230 USA.
   [Martin-Cook, Kristin; Womack, Kyle; Hart, John, Jr.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Texas System; University of Texas Dallas; University of
   Texas System; University of Texas Southwestern Medical Center Dallas
RI Womack, Kyle B/O-5422-2018
OI Womack, Kyle B/0000-0002-6060-9075
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MIT PRESS
PI CAMBRIDGE
PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA
SN 0898-929X
J9 J COGNITIVE NEUROSCI
JI J. Cogn. Neurosci.
PY 2013
SU S
BP 149
EP 149
PG 1
WC Neurosciences; Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Psychology
GA 118MV
UT WOS:000317030500600
DA 2023-08-17
ER

PT J
AU Tseriotis, V
   Spilioti, M
   Eleftheriadou, K
   Malliou, F
   Tsolaki, M
AF Tseriotis, V.
   Spilioti, M.
   Eleftheriadou, K.
   Malliou, F.
   Tsolaki, M.
TI Criticality in Electroencephalograms of patients with Mild Cognitive
   Impairment after Prospective Memory training
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Meeting Abstract
C1 [Tseriotis, V.] Aristotle Univ Thessaloniki, Lab Physiol, Thessaloniki, Greece.
   [Eleftheriadou, K.] Agios Pavlos Gen Hosp Thessaloniki, Thessaloniki, Greece.
   [Tsolaki, M.] Greek Assoc Alzheimers Dis & Related Disorders Al, Thessaloniki, Greece.
   [Spilioti, M.] Aristotle Univ Thessaloniki, AHEPA Gen Hosp, Thessaloniki, Greece.
   [Malliou, F.] Aristotle Univ Thessaloniki, Lab Clin Pharmacol, Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Ahepa University Hospital; Aristotle University of
   Thessaloniki
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-5101
EI 1468-1331
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD JUL
PY 2022
VL 29
SU 1
MA EPO-492
BP 696
EP 696
PG 1
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 2I8XE
UT WOS:000815254003177
DA 2023-08-17
ER

PT J
AU Olchik, MR
   Farina, J
   Steibel, N
   Teixeira, AR
   Yassuda, MS
AF Olchik, Maira Rozenfeld
   Farina, Jeanette
   Steibel, Nicole
   Teixeira, Adriane Ribeiro
   Yassuda, Monica Sanches
TI Memory training (MT) in mild cognitive impairment (MCI) generates change
   in cognitive performance
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Aging; MCI; MT; Cognitive training; Cognition
ID ALZHEIMERS-DISEASE; OLDER-ADULTS; INTERVENTION; DEMENTIA; EDUCATION;
   OUTCOMES; FLUENCY; AGE
AB Background: Longevity can be accompanied by several challenges, among them cognitive decline. The early identification of cognitive impairment offers the opportunity to act with the aim of preventing or delaying dementia. One potential intervention measure is MT.
   Objectives: To test the effect of MT in a sample of older individuals previously identified as having MCI.
   Methods: A randomized controlled clinical trial was carried out. Subjects were recruited by the local media for a memory study and were submitted to a battery of cognitive tests. Subjects meeting inclusion criteria (n = 112) were classified as normal controls (n = 65) and MCI (n = 47), according to Gauthier and Touchon's criteria (Gauthier & Touchon, 2005). The study sample was randomly assigned to three different intervention groups: MT group, educational intervention (EI) group, and control group (CG). The MT group received eight training sessions to learn mnemonic strategies based on ecological tasks. They also completed tasks which recruited attention and executive functions. Educational content on memory and aging was also offered. The EI participated in the same number of sessions, yet, only the educational content was offered. The CG completed pre- and post-test evaluations, and received training afterwards.
   Results: Training effects were modest and for certain variables they were equivalent to retest effects. However, after training, individuals with MCI in the MT group exhibited cognitive performance typical of individuals without cognitive impairment, suggesting cognitive plasticity.
   Conclusion: MT is a feasible non-pharmacological intervention which might bring positive performance change in older adults facing cognitive impairment. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Olchik, Maira Rozenfeld] Univ Fed Rio Grande do Sul, Sch Dent, Dept Surg & Orthoped, BR-90046900 Porto Alegre, RS, Brazil.
   [Farina, Jeanette; Steibel, Nicole] Moinhos de Vento Hosp, Porto Alegre, RS, Brazil.
   [Teixeira, Adriane Ribeiro] Univ Fed Rio Grande do Sul, Dept Dev Psychol & Personal, BR-90046900 Porto Alegre, RS, Brazil.
   [Yassuda, Monica Sanches] Univ Sao Paulo, Sch Arts Sci & Humanities, BR-05508 Sao Paulo, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Universidade de Sao Paulo
RP Yassuda, MS (corresponding author), Univ Sao Paulo, Sch Arts Sci & Humanities, BR-05508 Sao Paulo, Brazil.
RI olchik, maira/W-3999-2019; Teixeira, Adriane Ribeiro/W-4024-2019;
   Yassuda, Monica S/C-9693-2012; Yassuda, Monica Sanches/AAC-6219-2022
OI Teixeira, Adriane Ribeiro/0000-0003-4242-1666; Yassuda, Monica
   Sanches/0000-0002-9182-2450; Rozenfeld Olchik, Maira/0000-0002-8732-9225
CR Albert MS, 2011, ALZHEIMERS DEMENT, V7, P270, DOI 10.1016/j.jalz.2011.03.008
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NR 30
TC 46
Z9 49
U1 2
U2 108
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD MAY-JUN
PY 2013
VL 56
IS 3
BP 442
EP 447
DI 10.1016/j.archger.2012.11.007
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 088ZU
UT WOS:000314878100007
PM 23260332
DA 2023-08-17
ER

PT J
AU Gates, NJ
   Vernooij, RWM
   Di Nisio, M
   Karim, S
   March, E
   Martinez, G
   Rutjes, AWS
AF Gates, Nicola J.
   Vernooij, Robin W. M.
   Di Nisio, Marcello
   Karim, Salman
   March, Evrim
   Martinez, Gabriel
   Rutjes, Anne W. S.
TI Computerised cognitive training for preventing dementia people with mild
   cognitive impairment
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID HEALTHY OLDER-ADULTS; RANDOMIZED-CONTROLLED-TRIAL; GAMES ENHANCES
   ASPECTS; WORKING-MEMORY; ALZHEIMERS-DISEASE; EXERCISE PROGRAM;
   PHYSICAL-ACTIVITY; LEISURE ACTIVITIES; SINGLE-BLIND; RISK-FACTOR
AB Background
   The number of people living with dementia is increasing rapidly. Clinical dementia does not develop suddenly, but rather is preceded by a period of cognitive decline beyond normal age-related change. People at this intermediate stage between normal cognitive function and clinical dementia are often described as having mild cognitive impairment (MCI). Considerable research and clinical efforts have been directed toward finding disease-modifying interventions that may prevent or delay progression from MCI to clinical dementia.
   Objectives
   To evaluate the effects of at least 12 weeks of computerised cognitive training (CCT) on maintaining or improving cognitive function and preventing dementia in people with mild cognitive impairment.
   Search methods
   We searched to 31 May 2018 in ALOIS (www.medicine.ox.ac.uk/alois) and ran additional searches in MEDLINE, Embase, PsycINFO, CINAHL, ClinicalTrials.gov, and the WHO portal/ICTRP ( www.apps.who.int/trialsearch) to identify published, unpublished, and ongoing trials.
   Selection criteria
   We included randomised controlled trials (RCTs) and quasi-RCTs in which cognitive training via interactive computerised technology was compared with an active or inactive control intervention. Experimental computerised cognitive training (CCT) interventions had to adhere to the following criteria: minimum intervention duration of 12 weeks; any form of interactive computerised cognitive training, including computer exercises, computer games, mobile devices, gaming console, and virtual reality. Participants were adults with a diagnosis of mild cognitive impairment (MCI) or mild neurocognitive disorder (MND), or otherwise at high risk of cognitive decline.
   Data collection and analysis
   Two review authors independently extracted data and assessed risk of bias of the included RCTs. We expressed treatment effects as mean differences (MDs) or standardised mean differences (SMDs) for continuous outcomes and as risk ratios (RRs) for dichotomous outcomes. We used the GRADE approach to describe the overall quality of evidence for each outcome.
   Main results
   Eight RCTs with a total of 660 participants met review inclusion criteria. Duration of the included trials varied from 12 weeks to 18 months. Only one trial used an inactive control. Most studies were at unclear or high risk of bias in several domains. Overall, our ability to draw conclusions was hampered by very low-quality evidence. Almost all results were very imprecise; there were also problems related to risk of bias, inconsistency between trials, and indirectness of the evidence.
   No trial provided data on incident dementia. For comparisons of CCT with both active and inactive controls, the quality of evidence on our other primary outcome of global cognitive function immediately after the intervention period was very low. Therefore, we were unable to draw any conclusions about this outcome.
   Due to very low quality of evidence, we were also unable to determine whether there was any effect of CCT compared to active control on our secondary outcomes of episodic memory, working memory, executive function, depression, functional performance, and mortality. We found low-quality evidence suggesting that there is probably no effect on speed of processing (SMD 0.20, 95% confidence interval (CI) -0.16 to 0.56; 2 studies; 119 participants), verbal fluency (SMD -0.16, 95% CI -0.76 to 0.44; 3 studies; 150 participants), or quality of life (mean difference (MD) 0.40, 95% CI -1.85 to 2.65; 1 study; 19 participants).
   When CCT was compared with inactive control, we obtained data on five secondary outcomes, including episodic memory, executive function, verbal fluency, depression, and functional performance. We found very low-quality evidence; therefore, we were unable to draw any conclusions about these outcomes.
   Authors' conclusions
   Currently available evidence does not allow us to determine whether or not computerised cognitive training will prevent clinical dementia or improve or maintain cognitive function in those who already have evidence of cognitive impairment. Small numbers of trials, small samples, risk of bias, inconsistency between trials, and highly imprecise results mean that it is not possible to derive any implications for clinical practice, despite some observed large effect sizes from individual studies. Direct adverse events are unlikely to occur, although the time and sometimes the money involved in computerised cognitive training programmes may represent significant burdens. Further research is necessary and should concentrate on improving methodological rigour, selecting suitable outcomes measures, and assessing generalisability and persistence of any effects. Trials with long-term follow-up are needed to determine the potential of this intervention to reduce the risk of dementia.
C1 [Gates, Nicola J.] Univ New South Wales, Ctr Healthy Brain Ageing CHeBA, Suite 407,185 Elizabeth St, Sydney, NSW 2000, Australia.
   [Vernooij, Robin W. M.] Iberoamer Cochrane Ctr, Barcelona, Spain.
   [Di Nisio, Marcello] Univ G dAnnunzio, Dept Med & Ageing Sci, Chieti, Italy.
   [Karim, Salman] Lancashire Care NHS Fdn Trust, Psychiat, UK 5 St Vincents Adult Mental Hlth, Preston, Lancs, England.
   [March, Evrim] St Vincents Hosp Melbourne, St Vincents Adult Mental Hlth, Fitzroy, Vic, Australia.
   [Martinez, Gabriel] Univ Antofagasta, Fac Med & Dent, Antofagasta, Chile.
   [Rutjes, Anne W. S.] Univ Bern, ISPM, Bern, Switzerland.
   [Rutjes, Anne W. S.] Univ Bern, Inst Primary Hlth Care BIHAM, Bern, Switzerland.
C3 University of New South Wales Sydney; G d'Annunzio University of
   Chieti-Pescara; St Vincent's Hospital Melbourne; Universidad de
   Antofagasta; University of Bern; University of Bern
RP Gates, NJ (corresponding author), Univ New South Wales, Ctr Healthy Brain Ageing CHeBA, Suite 407,185 Elizabeth St, Sydney, NSW 2000, Australia.
EM n.gates@unsw.edu.au
RI Vernooij, Robin/N-3652-2018; Rutjes, Anne/L-8750-2017
OI Vernooij, Robin/0000-0001-5734-4566; Rutjes, Anne/0000-0001-9782-779X
FU National Institute for Health Research, UK; National Institute for
   Health Research, via a Cochrane Programme Grant; SERI; Horizon 2020;
   grant for the project 'OPERAM: OPtimising therapy to prevent Avoidable
   hospital admissions in the Multi-morbid elderly' - European Union's
   Horizon 2020 research and innovation programme [6342388]; Swiss State
   Secretariat for Education, Research, and Innovation (SERI) [15.0137]
FX National Institute for Health Research, UK.; This protocol was supported
   by the National Institute for Health Research, via a Cochrane Programme
   Grant to the Cochrane Dementia and Cognitive Improvement Group. The
   views and opinions expressed herein are those of the authors and do not
   necessarily reflect those of the Systematic Reviews Programme, NIHR,
   National Health Service (NHS), or the Department of Health.; SERI and
   Horizon 2020, Other.; The review authors AR and MdN are partially funded
   by a grant for the project 'OPERAM: OPtimising therapy to prevent
   Avoidable hospital admissions in the Multi-morbid elderly', supported by
   the European Union's Horizon 2020 research and innovation programme,
   under the grant agreement No. 6342388, and by the Swiss State
   Secretariat for Education, Research, and Innovation (SERI), under
   contract number 15.0137. The opinions expressed and the arguments
   employed herein are those of the review authors and do not necessarily
   reflect the official views of the EC and the Swiss government.
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   Youn JH, 2011, PSYCHIAT INVEST, V8, P354, DOI 10.4306/pi.2011.8.4.354
   Zelinski EM, 2011, ENHANCING COGNITIVE FITNESS IN ADULTS: A GUIDE TO THE USE AND DEVELOPMENT OF COMMUNITY-BASED PROGRAMS, P45, DOI 10.1007/978-1-4419-0636-6_3
   Zelinski EM, 2011, J AM GERIATR SOC, V59, P258, DOI 10.1111/j.1532-5415.2010.03277.x
   Zhuang JP, 2013, J ALZHEIMERS DIS, V36, P245, DOI 10.3233/JAD-130158
   Zimmermann N, 2014, NEUROREHABILITATION, V35, P159, DOI 10.3233/NRE-141104
NR 363
TC 60
Z9 61
U1 8
U2 59
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2019
IS 3
AR CD012279
DI 10.1002/14651858.CD012279.pub2
PG 120
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HR1ZM
UT WOS:000462935200024
PM 30864747
OA Green Published
DA 2023-08-17
ER

PT J
AU Hol, HR
   Flak, MM
   Chang, LD
   Lohaugen, GCC
   Bjuland, KJ
   Rimol, LM
   Engvig, A
   Skranes, J
   Ernst, T
   Madsen, BO
   Hernes, SS
AF Hol, Haakon R.
   Flak, Marianne M.
   Chang, Linda
   Lohaugen, Gro Christine Christensen
   Bjuland, Knut Jorgen
   Rimol, Lars M.
   Engvig, Andreas
   Skranes, Jon
   Ernst, Thomas
   Madsen, Bengt-Ove
   Hernes, Susanne S.
TI Cortical Thickness Changes After Computerized Working Memory Training in
   Patients With Mild Cognitive Impairment
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE cortical thickness; MCI; APOE genotype; LMX1A; working memory training
ID BRAIN PLASTICITY; IMPROVEMENT; CHILDREN; MCI; INTERVENTION; ACTIVATION;
   DIAGNOSIS; DOPAMINE; PATTERNS; VOLUME
AB BackgroundAdaptive computerized working memory (WM) training has shown favorable effects on cerebral cortical thickness as compared to non-adaptive training in healthy individuals. However, knowledge of WM training-related morphological changes in mild cognitive impairment (MCI) is limited. ObjectiveThe primary objective of this double-blind randomized study was to investigate differences in longitudinal cortical thickness trajectories after adaptive and non-adaptive WM training in patients with MCI. We also investigated the genotype effects on cortical thickness trajectories after WM training combining these two training groups using longitudinal structural magnetic resonance imaging (MRI) analysis in Freesurfer. MethodMagnetic resonance imaging acquisition at 1.5 T were performed at baseline, and after four- and 16-weeks post training. A total of 81 individuals with MCI accepted invitations to undergo 25 training sessions over 5 weeks. Longitudinal Linear Mixed effect models investigated the effect of adaptive vs. non-adaptive WM training. The LME model was fitted for each location (vertex). On all statistical analyzes, a threshold was applied to yield an expected false discovery rate (FDR) of 5%. A secondary LME model investigated the effects of LMX1A and APOE-epsilon 4 on cortical thickness trajectories after WM training. ResultsA total of 62 participants/patients completed the 25 training sessions. Structural MRI showed no group difference between the two training regimes in our MCI patients, contrary to previous reports in cognitively healthy adults. No significant structural cortical changes were found after training, regardless of training type, across all participants. However, LMX1A-AA carriers displayed increased cortical thickness trajectories or lack of decrease in two regions post-training compared to those with LMX1A-GG/GA. No training or training type effects were found in relation to the APOE-epsilon 4 gene variants. ConclusionThe MCI patients in our study, did not have improved cortical thickness after WM training with either adaptive or non-adaptive training. These results were derived from a heterogeneous population of MCI participants. The lack of changes in the cortical thickness trajectory after WM training may also suggest the lack of atrophy during this follow-up period. Our promising results of increased cortical thickness trajectory, suggesting greater neuroplasticity, in those with LMX1A-AA genotype need to be validated in future trials.
C1 [Hol, Haakon R.] Sorlandet Hosp, Dept Radiol, Arendal, Norway.
   [Hol, Haakon R.] Oslo Univ Hosp, Dept Radiol, Oslo, Norway.
   [Hol, Haakon R.; Hernes, Susanne S.] Univ Bergen, Dept Clin Sci, Bergen, Norway.
   [Flak, Marianne M.; Lohaugen, Gro Christine Christensen; Skranes, Jon] Sorlandet Hosp, Dept Pediat, Arendal, Norway.
   [Chang, Linda; Ernst, Thomas] Univ Maryland Sch Med, Dept Diagnost Radiol & Nucl Med, Baltimore, MD USA.
   [Chang, Linda] Univ Maryland, Dept Neurol, Sch Med, Baltimore, MD USA.
   [Chang, Linda; Ernst, Thomas] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD USA.
   [Bjuland, Knut Jorgen; Rimol, Lars M.; Skranes, Jon] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [Engvig, Andreas] Diakonhjemmet Hosp, Dept Med, Oslo, Norway.
   [Madsen, Bengt-Ove; Hernes, Susanne S.] Sorlandet Hosp, Dept Geriatr & Internal Med, Arendal, Norway.
C3 University of Oslo; University of Bergen; University System of Maryland;
   University of Maryland Baltimore; University System of Maryland;
   University of Maryland Baltimore; Johns Hopkins University; Norwegian
   University of Science & Technology (NTNU); Diakonhjemmet Hospital
RP Hol, HR (corresponding author), Sorlandet Hosp, Dept Radiol, Arendal, Norway.; Hol, HR (corresponding author), Oslo Univ Hosp, Dept Radiol, Oslo, Norway.; Hol, HR (corresponding author), Univ Bergen, Dept Clin Sci, Bergen, Norway.
EM haakon.ramsland.hol@ous-hf.no
RI Engvig, Andreas/HMV-2110-2023; Hernes, Susanne/H-7653-2019
OI Hernes, Susanne/0000-0001-6018-652X; Hol, Haakon
   Ramsland/0000-0001-5625-8308
FU South Eastern Norway Regional Health Authority [2015046, 2013059];
   Sorlandet Hospital HF; University of Maryland, School of Medicine; John
   A. Burns School of Medicine at the University of Hawai'i at Manoa
FX This study was funded by research grants from the South Eastern Norway
   Regional Health Authority (Grant Nos: 2015046 and 2013059), and
   Sorlandet Hospital HF. Chang's effort was supported by the University of
   Maryland, School of Medicine, and the John A. Burns School of Medicine
   at the University of Hawai`i at Manoa.
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NR 69
TC 0
Z9 0
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD APR 4
PY 2022
VL 14
AR 796110
DI 10.3389/fnagi.2022.796110
PG 11
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 0Y6MV
UT WOS:000790503900001
PM 35444526
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Belleville, S
AF Belleville, Sylvie
TI Cognitive training for persons with mild cognitive impairment
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article; Proceedings Paper
CT Conference on MCI in the Elderly and Populations at Risk
CY JAN 21-23, 2005
CL Bethesda, MD
SP Int Psychogeriatr Assoc
DE mild cognitive impairment; cognition; memory; cognitive training;
   cognitive intervention; memory training
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; MEMORY; REHABILITATION; INTERVENTION;
   PERFORMANCE; IMPROVEMENT; DEMENTIA; OUTCOMES; PROGRAM
AB Recent randomized control trials and meta-analyses of experimental studies indicate positive effects of non-pharmacological cognitive training on the cognitive function of healthy older adults. Furthermore, a large-scale randomized control trial with older adults, independent at entry, indicated that training delayed their cognitive and functional decline over a five-year follow-up. This supports cognitive training as a potentially efficient method to postpone cognitive decline in persons with mild cognitive impairment (MCI). Most of the research on the effect of cognitive training in MCI has reported increased performance following training on objective measures of memory whereas a minority reported no effect of training on objective cognitive measures. Interestingly, some of the studies that reported a positive effect of cognitive training in persons with MCI have observed large to moderate effect size. However, all of these studies have limited power and few have used long-term follow-ups or functional impact measures. Overall, this review highlights a need for a well-controlled randomized trial to assess the efficacy of cognitive training in MCI. It also raises a number of unresolved issues including proper outcome measures, issues of generalization and choice of intervention format.
C1 Inst Univ Geriatr Montreal, Res Ctr, Montreal, PQ, Canada.
C3 Universite de Montreal
RP Belleville, S (corresponding author), Inst Univ Geriatr Montreal, Res Ctr, 4565 Queen Mary, Montreal, PQ, Canada.
EM Sylvie.belleville@umontreal.ca
CR Adam S, 2000, NEUROPSYCHOL REHABIL, V10, P485, DOI 10.1080/09602010050143568
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   Belleville S, 2006, DEMENT GERIATR COGN, V22, P486, DOI 10.1159/000096316
   Brooks J O 3rd, 1999, Int Psychogeriatr, V11, P75
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NR 30
TC 160
Z9 169
U1 3
U2 64
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD FEB
PY 2008
VL 20
IS 1
BP 57
EP 66
DI 10.1017/S104161020700631X
PG 10
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Conference Proceedings Citation Index - Science (CPCI-S)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 352SX
UT WOS:000259518800007
PM 17958927
DA 2023-08-17
ER

PT J
AU Duff, K
   Ying, J
   Suhrie, KR
   Dalley, BCA
   Atkinson, TJ
   Porter, SM
   Dixon, AM
   Hammers, DB
   Wolinsky, FD
AF Duff, Kevin
   Ying, Jian
   Suhrie, Kayla R.
   Dalley, Bonnie C. A.
   Atkinson, Taylor J.
   Porter, Sariah M.
   Dixon, Ava M.
   Hammers, Dustin B.
   Wolinsky, Fredric D.
TI Computerized Cognitive Training in Amnestic Mild Cognitive Impairment: A
   Randomized Clinical Trial
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Article
DE mild cognitive impairment; clinical trial; computerized cognitive
   training; memory
AB Objective:
   Computerized cognitive training has been successful in healthy older adults, but its efficacy has been mixed in patients with amnestic Mild Cognitive Impairment (MCI).
   Methods:
   In a randomized, placebo-controlled, double-blind, parallel clinical trial, we examined the short- and long-term efficacy of a brain-plasticity computerized cognitive training in 113 participants with amnestic MCI.
   Results:
   Immediately after 40-hours of training, participants in the active control group who played computer games performed better than those in the experimental group on the primary cognitive outcome (p = 0.02), which was an auditory memory/attention composite score. There were no group differences on 2 secondary outcomes (global cognitive composite and rating of daily functioning). After 1 year, there was no difference between the 2 groups on primary or secondary outcomes. No adverse events were noted.
   Conclusions:
   Although the experimental cognitive training program did not improve outcomes in those with MCI, the short-term effects of the control group should not be dismissed, which may alter treatment recommendations for these patients.
C1 [Duff, Kevin; Suhrie, Kayla R.; Dalley, Bonnie C. A.; Atkinson, Taylor J.; Porter, Sariah M.; Dixon, Ava M.; Hammers, Dustin B.] Univ Utah, Dept Neurol, Ctr Alzheimers Care Imaging & Res, Salt Lake City, UT 84112 USA.
   [Ying, Jian] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.
   [Atkinson, Taylor J.] Univ S Florida, Sch Aging Studies, Tampa, FL 33620 USA.
   [Wolinsky, Fredric D.] Univ Iowa, Coll Publ Hlth, Iowa City, IA 52242 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah; State University System of
   Florida; University of South Florida; University of Iowa
RP Duff, K (corresponding author), Univ Utah, Dept Neurol, Ctr Alzheimers Care Imaging & Res, Salt Lake City, UT 84112 USA.
EM kevin.duff@hsc.utah.edu
RI Atkinson, Taylor/AAZ-9741-2021; Duff, Kevin/JAD-0032-2023
OI Atkinson, Taylor/0000-0003-4403-3704; Duff, Kevin/0000-0002-9336-2400
FU National Institutes on Aging [R01AG045163]; NCATS/NIH [8UL1TR000105];
   U.S. National Institutes of Health as part of the Clinical Translational
   Science Award (CTSA) program; NIA Alzheimer's Disease Cooperative Study
   (NIA) [AG10483]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   project described was supported by research grants from the National
   Institutes on Aging: R01AG045163, and it was registered at
   clinicaltrials. gov (NCT02301546). The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institute on Aging or the National
   Institutes of Health. This project also utilized REDCap, which is
   supported by 8UL1TR000105 (formerly UL1RR025764) NCATS/NIH. Recruitment
   for the study included ResearchMatch, a national health volunteer
   registry that was created by several academic institutions and supported
   by the U.S. National Institutes of Health as part of the Clinical
   Translational Science Award (CTSA) program. The ADCS-ADL-MCI was used
   with permission from the NIA Alzheimer's Disease Cooperative Study (NIA
   Grant AG10483).
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NR 33
TC 5
Z9 5
U1 3
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
EI 1552-5708
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD MAY
PY 2022
VL 35
IS 3
BP 400
EP 409
AR 08919887211006472
DI 10.1177/08919887211006472
EA MAR 2021
PG 10
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA 0I8MY
UT WOS:000635305700001
PM 33783254
DA 2023-08-17
ER

PT J
AU Bhatti, GK
   Reddy, AP
   Reddy, PH
   Bhatti, JS
AF Bhatti, Gurjit Kaur
   Reddy, Arubala P.
   Reddy, P. Hemachandra
   Bhatti, Jasvinder Singh
TI Lifestyle Modifications and Nutritional Interventions in
   Aging-Associated Cognitive Decline and Alzheimer's Disease
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE Alzheimer's disease; oxidative stress; inflammation; diet; exercise;
   lifestyle; nutraceuticals; antioxidants
ID ACTIVATED PROTEIN-KINASE; MEDITERRANEAN DIET; AMYLOID-BETA; CALORIE
   RESTRICTION; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; DNA
   METHYLATION; RISK-FACTORS; NEURODEGENERATIVE DISEASES; EPIGENETIC
   MODIFICATIONS
AB Alzheimer's disease (AD) is a type of incurable neurodegenerative disease that is characterized by the accumulation of amyloid-beta (A beta; plaques) and tau hyperphosphorylation as neurofibrillary tangles (NFTs) in the brain followed by neuronal death, cognitive decline, and memory loss. The high prevalence of AD in the developed world has become a major public health challenge associated with social and economic burdens on individuals and society. Due to there being limited options for early diagnosis and determining the exact pathophysiology of AD, finding effective therapeutic strategies has become a great challenge. Several possible risk factors associated with AD pathology have been identified; however, their roles are still inconclusive. Recent clinical trials of the drugs targeting A beta and tau have failed to find a cure for the AD pathology. Therefore, effective preventive strategies should be followed to reduce the exponential increase in the prevalence of cognitive decline and dementia, especially AD. Although the search for new therapeutic targets is a great challenge for the scientific community, the roles of lifestyle interventions and nutraceuticals in the prevention of many metabolic and neurodegenerative diseases are highly appreciated in the literature. In this article, we summarize the molecular mechanisms involved in AD pathology and the possible ameliorative action of lifestyle and nutritional interventions including diet, exercise, Calorie restriction (CR), and various bioactive compounds on cognitive decline and dementia. This article will provide insights into the role of non-pharmacologic interventions in the modulation of AD pathology, which may offer the benefit of improving quality of life by reducing cognitive decline and incident AD.
C1 [Bhatti, Gurjit Kaur] Chandigarh Univ, Univ Inst Appl Hlth Sci, Dept Med Lab Technol, Mohali, India.
   [Reddy, Arubala P.] Texas Tech Univ, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Internal Med, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Neurosci & Pharmacol, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Dept Sch Med, Neurol, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Publ Hlth Dept, Grad Sch Biomed Sci, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Sch Hlth Profess, Speech Language & Hearing Sci Dept, Lubbock, TX 79430 USA.
   [Bhatti, Jasvinder Singh] Sri Guru Gobind Singh Coll, Dept Biotechnol & Microbial Biotechnol, Chandigarh, India.
C3 Chandigarh University; Texas Tech University System; Texas Tech
   University; Texas Tech University Health Science Center; Texas Tech
   University System; Texas Tech University; Texas Tech University Health
   Science Center; Texas Tech University System; Texas Tech University;
   Texas Tech University Health Science Center; Texas Tech University
   System; Texas Tech University; Texas Tech University Health Science
   Center; Texas Tech University System; Texas Tech University; Texas Tech
   University Health Science Center; Texas Tech University System; Texas
   Tech University; Texas Tech University Health Science Center
RP Bhatti, JS (corresponding author), Sri Guru Gobind Singh Coll, Dept Biotechnol & Microbial Biotechnol, Chandigarh, India.
EM jasvinderbhatti@yahoo.com
RI Bhatti, Gurjit Kaur/AAU-6478-2020
OI Bhatti, Dr. Jasvinder Singh/0000-0001-5480-2584; Bhatti, Gurjit
   Kaur/0000-0003-0575-7427
FU National Institutes of Health (NIH) [AG042178, AG047812, NS105473];
   Garrison Family Foundation at Texas Tech University; CH Foundation;
   Alzheimer's Association through a SAGA grant; Alzheimer's Association
   New Investigator Research Grant [2016-NIRG-39787]; Center of Excellence
   for Translational Neuroscience and Therapeutics [PN-CTNT20115-AR]
FX The research presented in this article was supported by National
   Institutes of Health (NIH) grants AG042178, AG047812, and NS105473; the
   Garrison Family Foundation at Texas Tech University; the CH Foundation;
   and Alzheimer's Association through a SAGA grant (to PR). This research
   was also supported by the Alzheimer's Association New Investigator
   Research Grant 2016-NIRG-39787, the Center of Excellence for
   Translational Neuroscience and Therapeutics (PN-CTNT20115-AR), and
   Alzheimer's Association through a SAGA grant (to AR).
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NR 202
TC 55
Z9 57
U1 1
U2 36
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JAN 10
PY 2020
VL 11
AR 369
DI 10.3389/fnagi.2019.00369
PG 15
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA KF6LN
UT WOS:000509351300001
PM 31998117
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Antonenko, D
   Thams, F
   Uhrich, J
   Dix, A
   Thurm, F
   Li, SC
   Grittner, U
   Floel, A
AF Antonenko, Daria
   Thams, Friederike
   Uhrich, Jessica
   Dix, Annika
   Thurm, Franka
   Li, Shu-Chen
   Grittner, Ulrike
   Floeel, Agnes
TI Effects of a Multi-Session Cognitive Training Combined With Brain
   Stimulation (TrainStim-Cog) on Age-Associated Cognitive Decline - Study
   Protocol for a Randomized Controlled Phase IIb (Monocenter) Trial
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE transcranial direct current stimulation; aging; cognitive training;
   working memory; decision-making; spatial learning; transfer
ID TRANSCRANIAL ELECTRICAL-STIMULATION; WORKING-MEMORY; DIFFUSION MRI;
   FUNCTIONAL CONNECTIVITY; CORTICAL STIMULATION; ALZHEIMERS-DISEASE; TDCS;
   PLASTICITY; BDNF; POLYMORPHISMS
AB Background: With increasing aging populations worldwide, developing interventions against age-associated cognitive decline is particularly important. Evidence suggests that combination of brain stimulation with cognitive training intervention may enhance training effects in terms of performance gain or transfer to untrained domains. This protocol describes a Phase IIb clinical trial that investigates the intervention effects of training combined with brain stimulation in older adults.
   Methods: The TrainStim-Cog study is a monocentric, randomized, single-blind, placebo-controlled intervention. The study will investigate cognitive training with concurrent anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (target intervention) compared to cognitive training with sham stimulation (control intervention) over nine sessions in 3 weeks, consisting of a letter updating task, and a three-stage Markov decision-making task. Fifty-six older adults will be recruited from the general population. Baseline assessment will be performed including neuropsychological screening and performance on training tasks. Participants will be allocated to one of the two study arms using block-wise randomization stratified by age and baseline performance with a 1:1 allocation ratio. Primary outcome is performance in the letter updating task after training under anodal tDCS compared to sham stimulation. Secondary outcomes include performance changes in the decision-making task and transfer tasks, as well as brain structure and functional networks assessed by structural, and functional magnetic resonance imaging (MRI) that are acquired pre- and post-intervention.
   Significance: The main aim of the TrainStim-Cog study is to provide evidence for behavioral and neuronal effects of tDCS-accompanied cognitive training and to elucidate the underlying mechanisms in older adults. Our findings will contribute toward developing efficient interventions for age-associated cognitive decline.
C1 [Antonenko, Daria; Thams, Friederike; Uhrich, Jessica; Floeel, Agnes] Univ Med Greifswald, Dept Neurol, Greifswald, Germany.
   [Dix, Annika; Thurm, Franka; Li, Shu-Chen] Tech Univ Dresden, Chair Lifespan Dev Neurosci, Fac Psychol, Dresden, Germany.
   [Grittner, Ulrike] BIH, Berlin, Germany.
   [Grittner, Ulrike] Charite Univ Med Berlin, Berlin, Germany.
   [Grittner, Ulrike] Free Univ Berlin, Berlin, Germany.
   [Grittner, Ulrike] Humboldt Univ, Berlin, Germany.
   [Grittner, Ulrike] Berlin Inst Hlth, Inst Biometry & Clin Epidemiol, Berlin, Germany.
   [Floeel, Agnes] German Ctr Neurodegenerat Dis DZNE Standort Greif, Greifswald, Germany.
C3 Greifswald Medical School; Technische Universitat Dresden; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin;
   Humboldt University of Berlin; Berlin Institute of Health
RP Antonenko, D; Floel, A (corresponding author), Univ Med Greifswald, Dept Neurol, Greifswald, Germany.; Floel, A (corresponding author), German Ctr Neurodegenerat Dis DZNE Standort Greif, Greifswald, Germany.
EM daria.antonenko@uni-greifswald.de; agnes.floeel@med.uni-greifswald.de
RI Li, Shu-Chen/K-7838-2012; Grittner, Ulrike/I-2026-2019
OI Li, Shu-Chen/0000-0002-5520-5789; Grittner, Ulrike/0000-0003-2595-0224;
   Glockner, Franka/0000-0001-9684-7705; Li, Shu-Chen/0000-0001-8409-5390
FU Bundesministerium fur Bildung und Forschung [FKZ 01GQ1424A]
FX Funding for this study was provided by the "Bundesministerium fur
   Bildung und Forschung" (FKZ 01GQ1424A).
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NR 67
TC 11
Z9 11
U1 3
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD AUG 16
PY 2019
VL 11
AR 200
DI 10.3389/fnagi.2019.00200
PG 12
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA IR4XC
UT WOS:000481436600001
PM 31474848
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Finn, M
   McDonald, S
AF Finn, M.
   McDonald, S.
TI Improvement in visual sustained attention following cognitive training
   in mild cognitive impairment
SO AUSTRALASIAN JOURNAL ON AGEING
LA English
DT Meeting Abstract
C1 [Finn, M.; McDonald, S.] Univ New S Wales, Sydney, NSW, Australia.
   [Finn, M.] Royal N Shore Hosp, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; Royal North Shore Hospital;
   University of Sydney
NR 0
TC 3
Z9 3
U1 0
U2 2
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1440-6381
J9 AUSTRALAS J AGEING
JI Australas. Ageing
PD NOV
PY 2010
VL 29
SU 2
BP 15
EP 15
PG 1
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 666YN
UT WOS:000283159100033
DA 2023-08-17
ER

PT J
AU Orgeta, V
   McDonald, KR
   Poliakoff, E
   Hindle, JV
   Clare, L
   Leroi, I
AF Orgeta, Vasiliki
   McDonald, Kathryn R.
   Poliakoff, Ellen
   Hindle, John Vincent
   Clare, Linda
   Leroi, Iracema
TI Cognitive training interventions for dementia and mild cognitive
   impairment in Parkinson's disease
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; RANDOMIZED-TRIAL; DIFFERENTIATE
   ALZHEIMERS; DIAGNOSTIC-CRITERIA; DOUBLE-BLIND; TEST BATTERY; TASK-FORCE;
   REHABILITATION; MEMORY
AB Background
   Approximately 60% to 80% of people with Parkinson's disease (PD) experience cognitive impairment that impacts on their quality of life. Cognitive decline is a core feature of the disease and can often present before the onset of motor symptoms. Cognitive training may be a useful non-pharmacological intervention that could help to maintain or improve cognition and quality of life for people with PD dementia (PDD) or PD-related mild cognitive impairment (PD-MCI).
   Objectives
   To determine whether cognitive training (targeting single or multiple domains) improves cognition in people with PDD and PD-MCI or other clearly defined forms of cognitive impairment in people with PD.
   Search methods
   We searched the Cochrane Dementia and Cognitive Improvement Group Trials Register (8 August 2019), the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, and PsycINFO. We searched reference lists and trial registers, searched relevant reviews in the area and conference proceedings. We also contacted experts for clarifications on data and ongoing trials.
   Selection criteria
   We included randomised controlled trials where the participants had PDD or PD-MCI, and where the intervention was intended to train general or specific areas of cognitive function, targeting either a single domain or multiple domains of cognition, and was compared to a control condition. Multicomponent interventions that also included motor or other elements were considered eligible.
   Data collection and analysis
   Two review authors independently screened titles, abstracts, and full-text articles for inclusion in the review. Two review authors also independently undertook extraction of data and assessment of methodological quality. We used GRADE methods to assess the overall quality of the evidence.
   Main results
   Seven studies with a total of 225 participants met the inclusion criteria for this review. All seven studies compared the effects of a cognitive training intervention to a control intervention at the end of treatment periods lasting four to eight weeks. Six studies included people with PD living in the community. These six studies recruited people with single-domain (executive) or multiple-domain mild cognitive impairment in PD. Four of these studies identified participants with MCI using established diagnostic criteria, and two included both people with PD-MCI and people with PD who were not cognitively impaired. One study recruited people with a diagnosis of PD dementia who were living in long-term care settings. The cognitive training intervention in three studies targeted a single cognitive domain, whilst in four studies multiple domains of cognitive function were targeted. The comparison groups either received no intervention or took part in recreational activities (sports, music, arts), speech or language exercises, computerised motor therapy, or motor rehabilitation combined with recreational activity.
   We found no clear evidence that cognitive training improved global cognition. Although cognitive training was associated with higher scores on global cognition at the end of treatment, the result was imprecise and not statistically significant (6 trials, 178 participants, standardised mean difference (SMD) 0.28, 95% confidence interval (CI) -0.03 to 0.59; low-certainty evidence). There was no evidence of a difference at the end of treatment between cognitive training and control interventions on executive function (5 trials, 112 participants; SMD 0.10, 95% CI -0.28 to 0.48; low-certainty evidence) or visual processing (3 trials, 64 participants; SMD 0.30, 95% CI -0.21 to 0.81; low-certainty evidence). The evidence favoured the cognitive training group on attention (5 trials, 160 participants; SMD 0.36, 95% CI 0.03 to 0.68; low-certainty evidence) and verbal memory (5 trials, 160 participants; SMD 0.37, 95% CI 0.04 to 0.69; low-certainty evidence), but these effects were less certain in sensitivity analyses that excluded a study in which only a minority of the sample were cognitively impaired. There was no evidence of differences between treatment and control groups in activities of daily living (3 trials, 67 participants; SMD 0.03, 95% CI -0.47 to 0.53; low-certainty evidence) or quality of life (5 trials, 147 participants; SMD -0.01, 95% CI -0.35 to 0.33; low-certainty evidence). There was very little information on adverse events. We considered the certainty of the evidence for all outcomes to be low due to risk of bias in the included studies and imprecision of the results.
   We identified six ongoing trials recruiting participants with PD-MCI, but no ongoing trials of cognitive training for people with PDD.
   Authors' conclusions
   This review found no evidence that people with PD-MCI or PDD who receive cognitive training for four to eight weeks experience any important cognitive improvements at the end of training. However, this conclusion was based on a small number of studies with few participants, limitations of study design and execution, and imprecise results. There is a need for more robust, adequately powered studies of cognitive training before conclusions can be drawn about the effectiveness of cognitive training for people with PDD and PD-MCI. Studies should use formal criteria to diagnose cognitive impairments, and there is a particular need for more studies testing the efficacy of cognitive training in people with PDD.
C1 [Orgeta, Vasiliki] UCL, Div Psychiat, 6th Floor,Maple House,149 Tottenham Court Rd, London W1T 7NF, England.
   [McDonald, Kathryn R.] Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Neurosci & Expt Psychol, Manchester, Lancs, England.
   [Poliakoff, Ellen] Sch Biol Sci, Div Neurosci & Expt Psychol, Manchester, Lancs, England.
   [Hindle, John Vincent] Betsi Cadwaladr Univ Hlth Board, Llandudno Hosp, Care Elderly Dept, Llandudno, Wales.
   [Clare, Linda] Univ Exeter, REACH Ctr Res Ageing & Cognit Hlth, Exeter, Devon, England.
   [Leroi, Iracema] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland.
C3 University of London; University College London; N8 Research
   Partnership; University of Manchester; N8 Research Partnership;
   University of Manchester; University of Exeter; Trinity College Dublin
RP Orgeta, V (corresponding author), UCL, Div Psychiat, 6th Floor,Maple House,149 Tottenham Court Rd, London W1T 7NF, England.
EM v.orgeta@ucl.ac.uk
RI Poliakoff, Ellen/N-9910-2015
OI Poliakoff, Ellen/0000-0003-4975-7787; Orgeta,
   Vasiliki/0000-0001-8643-5061; Leroi, Iracema/0000-0003-1822-3643; Clare,
   Linda/0000-0003-3989-5318
FU National Institute for Health Research (NIHR), UK; National Institute
   for Health Research (NIHR) via the Cochrane Infrastructure Funding
FX External sources; National Institute for Health Research (NIHR), UK.
   This review was supported by the National Institute for Health Research
   (NIHR) via the Cochrane Infrastructure Funding to the Cochrane Dementia
   and Cognitive Improvement Group. The views and opinions expressed
   therein are those of the authors and do not necessarily reflect those of
   the Systematic Reviews Programme, NIHR, National Health Service (NHS),
   or the Department of Health.
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NR 186
TC 50
Z9 50
U1 4
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2020
IS 2
AR CD011961
DI 10.1002/14651858.CD011961.pub2
PG 65
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA KQ8MZ
UT WOS:000517176800001
PM 32101639
OA Green Published
DA 2023-08-17
ER

PT J
AU Werheid, K
   Ziegler, M
   Klapper, A
   Kuhl, KP
AF Werheid, Katja
   Ziegler, Matthias
   Klapper, Annina
   Kuehl, Klaus-Peter
TI Awareness of Memory Failures and Motivation for Cognitive Training in
   Mild Cognitive Impairment
SO DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
LA English
DT Article
DE Awareness; Cognitive training; Therapy motivation; Mild cognitive
   impairment; Subjective memory complaints; Cognitive deficits;
   Anosognosia
ID STAGE ALZHEIMERS-DISEASE; FUNCTIONING QUESTIONNAIRE; OBJECTIVE MEMORY;
   COMPLAINTS; SELF; ANOSOGNOSIA; PERFORMANCE; DEMENTIA; VALIDITY
AB Background: Awareness of cognitive deficits is considered to be decisive for the effectiveness of cognitive training in mild cognitive impairment (MCI). However, it is unclear in what way awareness influences motivation to participate in cognitive training. Methods: Thirty-two elderly adults with MCI and 72 controls completed the 5-scale Memory Functioning Questionnaire (MFQ) and a motivation questionnaire. The predictive value of the MFQ scales on motivation was analyzed using regression analysis. Results: In the MCI group, but not in controls, higher perceived frequency of memory failures was associated with a lower motivation score. Conclusion: Our findings indicate that, in MCI, greater awareness of cognitive deficits does not necessarily increase motivation to participate in cognitive trainings, and suggest that success expectancy may be a moderating factor. Copyright (C) 2010 S. Karger AG, Basel
C1 [Werheid, Katja; Ziegler, Matthias] Humboldt Univ, Dept Psychol, DE-12489 Berlin, Germany.
   [Kuehl, Klaus-Peter] Charite, Dept Psychiat, D-13353 Berlin, Germany.
   [Klapper, Annina] Univ Giessen, Dept Psychol, Giessen, Germany.
C3 Humboldt University of Berlin; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Justus Liebig
   University Giessen
RP Werheid, K (corresponding author), Humboldt Univ, Dept Psychol, Rudower Chaussee 18, DE-12489 Berlin, Germany.
EM katja.werheid@cms.hu-berlin.de
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BP 155
EP 160
DI 10.1159/000318755
PG 6
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA 651YR
UT WOS:000281965700007
PM 20733308
DA 2023-08-17
ER

PT J
AU Nwosu, A
   Qian, M
   Phillips, J
   Hellegers, CA
   Rushia, S
   Sneed, J
   Petrella, JR
   Goldberg, TE
   Devanand, DP
   Doraiswamy, PM
AF Nwosu, Adaora
   Qian, M.
   Phillips, J.
   Hellegers, C. A.
   Rushia, S.
   Sneed, J.
   Petrella, J. R.
   Goldberg, T. E.
   Devanand, D. P.
   Doraiswamy, P. M.
TI Computerized Cognitive Training in Mild Cognitive Impairment: Findings
   in African Americans and Caucasians
SO JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
LA English
DT Article; Early Access
DE Race; ethnicity; health disparities; brain health; Alzheimer's
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; DEMENTIA; MEMORY; PROGRAM;
   INTERVENTIONS; IMPACT
AB BACKGROUND: African Americans with MCI may be at increased risk for dementia compared to Caucasians. The effect of race on the efficacy of cognitive training in MCI is unclear.
   METHODS: We used data from a two-site, 78-week randomized trial of MCI comparing intensive, home-based, computerized training with Web-based cognitive games or Web-based crossword puzzles to examine the effect of race on outcomes. The study outcomes were changes from baseline in cognitive and functional scales as well as MRI-measured changes in hippocampal volume and cortical thickness. Analyses used linear models adjusted for baseline scores. This was an exploratory study.
   RESULTS: A total of 105 subjects were included comprising 81 whites ( 77.1%) and 24 African Americans ( 22.8%). The effect of race on the change from baseline in ADAS-Cog-11 was not significant. The effect of race on change from baseline to week 78 in the Functional Activities Questionnaire (FAQ) was significant with African American participants' FAQ scores showing greater improvements at weeks 52 and 78 (P = 0.009, P = 0.0002, respectively) than white subjects. Within the CCT cohort, FAQ scores for African American participants showed greater improvement between baseline and week 78, compared to white participants randomized to CCT (P = 0.006). There was no effect of race on the UPSA. There was no effect of race on hippocampal or cortical thickness outcomes.
   CONCLUSIONS: Our preliminary findings suggest that web-based cognitive training programs may benefit African Americans with MCI at least as much as Caucasians, and highlight the need to further study underrepresented minorities in AD prevention trials.
C1 [Nwosu, Adaora; Hellegers, C. A.; Doraiswamy, P. M.] Duke Univ, Dept Psychiat & Behav Sci, Neurocognit Disorders Program, Sch Med, Durham, NC 27708 USA.
   [Qian, M.] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, Med Ctr, New York, NY USA.
   [Phillips, J.; Goldberg, T. E.; Devanand, D. P.] New York State Psychiat Inst & Hosp, Area Brain Aging & Mental Hlth, New York, NY USA.
   [Phillips, J.; Goldberg, T. E.; Devanand, D. P.] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA.
   [Rushia, S.] Univ Massachusetts, Dept Psychiat, Chan Med Sch, Worcester, MA USA.
   [Sneed, J.] City Univ New York, Queens Coll, New York, NY USA.
   [Petrella, J. R.] Duke Univ, Dept Radiol, Sch Med, Durham, NC USA.
   [Doraiswamy, P. M.] Duke Sch Med, Ctr Study Aging & Human Dev, Durham, NC USA.
   [Doraiswamy, P. M.] Duke Sch Med, Div Geriatr, Durham, NC USA.
C3 Duke University; Columbia University; New York State Psychiatry
   Institute; Columbia University; University of Massachusetts System;
   University of Massachusetts Worcester; City University of New York
   (CUNY) System; Queens College NY (CUNY); Duke University; Duke
   University; Duke University
RP Nwosu, A (corresponding author), Duke Univ, Dept Psychiat & Behav Sci, Neurocognit Disorders Program, Sch Med, Durham, NC 27708 USA.
EM adaora.nwosu@duke.edu
CR [Anonymous], 2023, ALZHEIMERS DEMENT, V19, P1598, DOI 10.1002/alz.13016
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 2274-5807
EI 2426-0266
J9 JPAD-J PREV ALZHEIM
JI JPAD-J. Prev. Alzheimers Dis.
PD 2023 JUN 13
PY 2023
DI 10.14283/jpad.2023.80
EA JUN 2023
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA I6SS7
UT WOS:001004068900003
DA 2023-08-17
ER

PT J
AU Villar, V
   Rojas, G
   Harris, P
   Serrano, C
   Dillon, C
   Iturry, M
   Bartoloni, L
   Allegri, R
AF Villar, Veronica
   Rojas, Galeno
   Harris, Paula
   Serrano, Cecilia
   Dillon, Carol
   Iturry, Monica
   Bartoloni, Leonardo
   Allegri, Ricardo
TI Cognitive Training and Long Term Follow-Up in Patients with Mild
   Cognitive Impairment
SO NEUROLOGY
LA English
DT Meeting Abstract
CT 62nd Annual Meeting of the American-Academy-of-Neurology
CY APR 10-17, 2010
CL Toronto, CANADA
SP Amer Acad Neurol
RI ALLEGRI, RICARDO FRANCISCO/AAY-4898-2021
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD MAR 2
PY 2010
VL 74
IS 9
SU 2
BP A151
EP A151
PG 1
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology
GA 565FG
UT WOS:000275274000590
DA 2023-08-17
ER

PT J
AU Herrera, C
   Chambon, C
   Michel, BF
   Paban, V
   Alescio-Lautier, B
AF Herrera, C.
   Chambon, C.
   Michel, B. F.
   Paban, V.
   Alescio-Lautier, B.
TI Positive effects of computer-based cognitive training in adults with
   mild cognitive impairment
SO NEUROPSYCHOLOGIA
LA English
DT Article
DE Memory and attention training; Neuroplasticity; Aging; Episodic recall;
   Recognition
ID SHORT-TERM-MEMORY; ENVIRONMENTAL ENRICHMENT; REHABILITATION PROGRAM;
   CHOLINERGIC DAMAGE; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX;
   WORKING-MEMORY; BRAIN RESERVE; OLDER-ADULTS; LIFE-SPAN
AB Considering the high risk for individuals with amnestic Mild Cognitive Impairment (A-MCI) to progress towards Alzheimer's disease (AD), we investigated the efficacy of a non-pharmacological intervention, that is, cognitive training that could reduce cognitive difficulties and delay the cognitive decline. For this, we evaluated the efficacy of a 12-week computer-based memory-attention training program based on recognition in subjects with A-MCI and compared their performances with those of A-MCI controls trained in cognitively stimulating activities. The effect of training was assessed by comparing outcome measures in pre- and post-tests 15 days before and after training. To evaluate the duration of training benefits, a follow-up test session was performed 6 months after memory and attention training or cognitively stimulating activities.
   Outcome measures showed that the trained group, compared to control group, improved episodic recall and recognition. Six months after training, scores remained at the level of the post-test.
   Since the training program was exclusively based on recognition, our results showed a generalization from recognition to recall processes, which are memory components that represent part of the core cognitive impairments in individuals at risk of converting to AD. Thus, cognitive training based on recognition holds promise as a preventive therapeutic method and could be proposed as a nonpharmacological early-intervention strategy. Future investigations need to focus on methodological constraints and delineating possible neuroplastic mechanisms of action. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Herrera, C.; Chambon, C.; Paban, V.; Alescio-Lautier, B.] Univ Provence, Univ Aix Marseille, CNRS, Lab Neurobiol Integrat & Adaptat,UMR 6149, F-13331 Marseille 03, France.
   [Herrera, C.; Michel, B. F.] Hop St Marguerite, Unite Neurol Comportementale, F-13009 Marseille, France.
C3 Centre National de la Recherche Scientifique (CNRS); UDICE-French
   Research Universities; Aix-Marseille Universite; UDICE-French Research
   Universities; Aix-Marseille Universite; Assistance Publique-Hopitaux de
   Marseille
RP Alescio-Lautier, B (corresponding author), Univ Provence, Univ Aix Marseille, CNRS, Lab Neurobiol Integrat & Adaptat,UMR 6149, 3 Pl Victor Hugo, F-13331 Marseille 03, France.
EM beatrice.alescio-lautier@univ-provence.fr
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NR 77
TC 91
Z9 97
U1 0
U2 55
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3932
EI 1873-3514
J9 NEUROPSYCHOLOGIA
JI Neuropsychologia
PD JUL
PY 2012
VL 50
IS 8
BP 1871
EP 1881
DI 10.1016/j.neuropsychologia.2012.04.012
PG 11
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA 982ES
UT WOS:000307025600017
PM 22525705
DA 2023-08-17
ER

PT J
AU Peter, J
   Schumacher, LV
   Landerer, V
   Abdulkadir, A
   Kaller, CP
   Lahr, J
   Kloppel, S
AF Peter, Jessica
   Schumacher, Lena V.
   Landerer, Verena
   Abdulkadir, Ahmed
   Kaller, Christoph P.
   Lahr, Jacob
   Kloeppel, Stefan
TI Biological Factors Contributing to the Response to Cognitive Training in
   Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Cognitive training; entorhinal cortex; episodic memory; mild cognitive
   impairment; response prediction
ID SUBJECTIVE MEMORY IMPAIRMENT; ALZHEIMERS-DISEASE; ENTORHINAL CORTEX;
   OLDER-ADULTS; HIPPOCAMPAL VOLUMES; CLINICAL-TRIAL; PLASTICITY; PROGRAM;
   DECLINE; AGE
AB In mild cognitive impairment (MCI), small benefits from cognitive training were observed for memory functions but there appears to be great variability in the response to treatment. Our study aimed to improve the characterization and selection of those participants who will benefit from cognitive intervention. We evaluated the predictive value of disease-specific biological factors for the outcome after cognitive training in MCI (n = 25) and also considered motivation of the participants. We compared the results of the cognitive intervention group with two independent control groups of MCI patients (local memory clinic, n = 20; ADNI cohort, n = 302). The primary outcome measure was episodic memory as measured by verbal delayed recall of a 10-word list. Episodic memory remained stable after treatment and slightly increased 6 months after the intervention. In contrast, in MCI patients who did not receive an intervention, episodic memory significantly decreased during the same time interval. A larger left entorhinal cortex predicted more improvement in episodic memory after treatment and so did higher levels of motivation. Adding disease-specific biological factors significantly improved the prediction of training-related change compared to a model based simply on age and baseline performance. Bootstrapping with resampling (n = 1000) verified the stability of our finding. Cognitive training might be particularly helpful in individuals with a bigger left entorhinal cortex as individuals who did not benefit from intervention showed 17% less volume in this area. When extended to alternative treatment options, stratification based on disease-specific biological factors is a useful step towards individualized medicine.
C1 [Peter, Jessica; Abdulkadir, Ahmed; Kloeppel, Stefan] Univ Bern, Univ Hosp Old Age Psychiat & Psychotherapy, Bern, Switzerland.
   [Peter, Jessica; Landerer, Verena; Lahr, Jacob] Univ Freiburg, Fac Med, Dept Psychiat & Psychotherapy, Freiburg, Germany.
   [Schumacher, Lena V.] Univ Freiburg, Fac Med, Med Psychol & Med Sociol, Freiburg, Germany.
   [Abdulkadir, Ahmed] Univ Freiburg, Dept Comp Sci, Freiburg, Germany.
   [Kaller, Christoph P.] Univ Freiburg, Dept Neurol, Fac Med, Freiburg, Germany.
   [Kaller, Christoph P.] Univ Freiburg, BrainLinks BrainTools Cluster Excellence, Freiburg, Germany.
   [Kloeppel, Stefan] Univ Freiburg, Fac Med, Ctr Geriatr Med & Gerontol, Freiburg, Germany.
C3 University of Bern; University Hospital of Bern; University of Freiburg;
   University of Freiburg; University of Freiburg; University of Freiburg;
   University of Freiburg; University of Freiburg
RP Peter, J (corresponding author), Univ Old Age Psychiat & Psychotherapy, Bolligenstrasse 111, D-3000 Bern 60, Germany.
EM jessica.peter@puk.unibe.ch
OI Schumacher, Lena/0000-0003-3785-9866; Kaller,
   Christoph/0000-0003-1206-889X; Kloppel, Stefan/0000-0001-6452-9964;
   Peter, Jessica/0000-0002-0817-8431; Abdulkadir,
   Ahmed/0000-0003-4679-8081
FU University Medical Centre Freiburg; Alzheimer's Disease Neuroimaging
   Initiative (ADNI) (National Institutes of Health) [U01AG024904]; DODADNI
   (Department of Defense) [W81XWH-12-2-0012]; National Institute on Aging;
   National Institute of Biomedical Imaging and Bioengineering; AbbVie;
   Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Araclon
   Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company;
   CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli
   Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd; Canadian
   Institutes of Health Research; Genentech, Inc.; Fujirebio; GE
   Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research &
   Development, LLC.; Johnson & Johnson Pharmaceutical Research &
   Development LLC.; Lumosity; Lundbeck; Merck Co., Inc.; Meso Scale
   Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis
   Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier;
   Takeda Pharmaceutical Company; Transition Therapeutics
FX JP was funded from the University Medical Centre Freiburg.; Data
   collection and sharing for the ADNI project was funded by the
   Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes
   of Health Grant U01AG024904) and DODADNI (Department of Defense award
   number W81XWH-12-2-0012). ADNI is funded by the National Institute on
   Aging, the National Institute of Biomedical Imaging and Bioengineering,
   and through generous contributions from the following: AbbVie,
   Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Araclon
   Biotech; BioClinica, Inc.; Biogen; Bristol-Myers Squibb Company;
   CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli
   Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its
   affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO
   Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.;
   Johnson & Johnson Pharmaceutical Research & Development LLC.; Lumosity;
   Lundbeck; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx
   Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation;
   Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company;
   and Transition Therapeutics. The Canadian Institutes of Health Research
   is providing funds to support ADNI clinical sites in Canada. Private
   sector contributions are facilitated by the Foundation for the National
   Institutes of Health (http://www.fnih.org). The grantee organization is
   the Northern California Institute for Research and Education, and the
   study is coordinated by the Alzheimer's Therapeutic Research Institute
   at the University of Southern California. ADNI data are disseminated by
   the Laboratory for Neuro Imaging at the University of Southern
   California.
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NR 47
TC 9
Z9 9
U1 2
U2 13
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2018
VL 61
IS 1
BP 333
EP 345
DI 10.3233/JAD-170580
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FN9OX
UT WOS:000416369700029
PM 29154279
OA Green Published, Bronze
DA 2023-08-17
ER

PT J
AU Rahe, J
   Liesk, J
   Rosen, JB
   Petrelli, A
   Kaesberg, S
   Onur, OA
   Kessler, J
   Fink, GR
   Kalbe, E
AF Rahe, Julia
   Liesk, Jennifer
   Rosen, Jan B.
   Petrelli, Annette
   Kaesberg, Stephanie
   Onur, Oezguer A.
   Kessler, Josef
   Fink, Gereon R.
   Kalbe, Elke
TI Sex differences in cognitive training effects of patients with amnestic
   mild cognitive impairment
SO AGING NEUROPSYCHOLOGY AND COGNITION
LA English
DT Article
DE mild cognitive impairment; sex difference; cognitive training effects;
   prevention of dementia; cognitive plasticity
ID HEALTHY OLDER-ADULTS; GENDER-DIFFERENCES; EPISODIC MEMORY; VERBAL
   MEMORY; ALZHEIMERS-DISEASE; SCREENING-TEST; RISK-FACTORS; AGE; BRAIN;
   WOMEN
AB Cognitive training has been shown to be effective in improving cognitive functions in patients with Mild Cognitive Impairment (MCI). However, data on factors that may influence training gains including sociodemographic variables such as sex or age is rare. In this study, the impact of sex on cognitive training effects was examined in N=32 age- and education-matched female (n=16) and male (n=16) amnestic MCI patients (total sample: age M=74.97, SD=5.21; education M=13.50, SD=3.11). Patients participated in a six-week multidomain cognitive training program including 12 sessions each 90 min twice weekly in mixed groups with both women and men. Various cognitive domains were assessed before and after the intervention. Despite comparable baseline performance in women and men, we found significant interaction effects Time x Sex in immediate (p = .04) and delayed verbal episodic memory (p= .045) as well as in working memory (p = .042) favoring the female MCI patients. In contrast, the overall analyses with the total sample did not reveal any significant within-subject effects Time. In conclusion, our results give preliminary evidence for stronger cognitive training improvements of female compared to male MCI patients. More generally, they emphasize the importance of sex-sensitive evaluations of cognitive training effects. Possible underlying mechanisms of the found sex differences are discussed and directions for future research are given.
C1 [Rahe, Julia; Liesk, Jennifer; Rosen, Jan B.; Petrelli, Annette; Kalbe, Elke] Univ Vechta, Inst Gerontol, Vechta, Germany.
   [Rahe, Julia; Liesk, Jennifer; Rosen, Jan B.; Petrelli, Annette; Kalbe, Elke] Univ Vechta, Ctr Neuropsychol Diagnost & Intervent CeNDI, Vechta, Germany.
   [Petrelli, Annette; Kaesberg, Stephanie; Onur, Oezguer A.; Kessler, Josef; Fink, Gereon R.; Kalbe, Elke] Univ Hosp Cologne, Dept Neurol, Cologne, Germany.
   [Kaesberg, Stephanie; Onur, Oezguer A.; Fink, Gereon R.] Res Ctr Julich, Inst Neurosci & Med INM 3, Cognit Neurosci, Julich, Germany.
C3 University of Cologne; Helmholtz Association; Research Center Julich
RP Kalbe, E (corresponding author), Univ Vechta, Inst Gerontol, Vechta, Germany.
EM elke.kalbe@uni-vechta.de
RI Fink, Gereon R./AFW-9377-2022; Fink, Gereon R./E-1616-2012
OI Fink, Gereon R./0000-0002-8230-1856; Fink, Gereon
   R./0000-0002-8230-1856; Onur, Oezguer/0000-0001-8336-7075
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NR 75
TC 15
Z9 15
U1 0
U2 41
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1382-5585
EI 1744-4128
J9 AGING NEUROPSYCHOL C
JI Aging Neuropsychol. Cogn.
PD SEP 3
PY 2015
VL 22
IS 5
BP 620
EP 638
DI 10.1080/13825585.2015.1028883
PG 19
WC Psychology, Developmental; Psychology, Experimental
WE Social Science Citation Index (SSCI)
SC Psychology
GA CK5VZ
UT WOS:000356295400007
PM 25818876
DA 2023-08-17
ER

PT J
AU Vermeij, A
   Claassen, JAHR
   Dautzenberg, PLJ
   Kessels, RPC
AF Vermeij, Anouk
   Claassen, Jurgen A. H. R.
   Dautzenberg, Paul L. J.
   Kessels, Roy P. C.
TI Transfer and maintenance effects of online working-memory training in
   normal ageing and mild cognitive impairment
SO NEUROPSYCHOLOGICAL REHABILITATION
LA English
DT Article
DE Cognitive ageing; Cognitive training; Computerised training; Mild
   cognitive impairment; Working memory
ID VERBAL-LEARNING-TEST; MINI-MENTAL-STATE; OLDER-ADULTS;
   ALZHEIMERS-DISEASE; AGE; PLASTICITY; DEFICITS; PERFORMANCE; DEMENTIA;
   GAINS
AB Working memory (WM) is one of the cognitive functions that is susceptible to ageing-related decline. Interventions that are able to improve WM functioning at older age are thus highly relevant. In this pilot study, we explored the transfer effects of core WM training on the WM domain and other cognitive domains in 23 healthy older adults and 18 patients with amnestic mild cognitive impairment (MCI). Performance on neuropsychological tests was assessed before and after completion of the online five-week adaptive WM training, and after a three-month follow-up period. After training, both groups improved on the Digit Span and Spatial Span, gains that were maintained at follow-up. At an individual level, a limited number of participants showed reliable training gain. Healthy older adults, and to a lesser extent MCI patients, additionally improved on figural fluency at group level, but not at individual level. Results furthermore showed that global brain atrophy and hippocampal atrophy, as assessed by MRI, may negatively affect training outcome. Our study examined core WM training, showing gains on trained and untrained tasks within the WM domain, but no broad generalisation to other cognitive domains. More research is needed to evaluate the clinical relevance of these findings and to identify participant characteristics that are predictive of training gain.
C1 [Vermeij, Anouk; Claassen, Jurgen A. H. R.; Kessels, Roy P. C.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
   [Vermeij, Anouk; Claassen, Jurgen A. H. R.] Radboud Univ Nijmegen, Med Ctr, Dept Geriatr Med, Route 925,POB 9101, NL-6500 HB Nijmegen, Netherlands.
   [Dautzenberg, Paul L. J.] Jeroen Bosch Hosp, Dept Geriatr Med, Shertogenbosch, Netherlands.
   [Kessels, Roy P. C.] Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Jeroen Bosch
   Ziekenhuis; Radboud University Nijmegen
RP Vermeij, A (corresponding author), Radboud Univ Nijmegen, Med Ctr, Dept Geriatr Med, Route 925,POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM Anouk.Vermeij@radboudumc.nl
RI Kessels, Roy P.C./D-1902-2010; Claassen, Jurgen A.H.R./A-9806-2008;
   Vermeij, Anouk/J-5934-2012
OI Kessels, Roy P.C./0000-0001-9500-9793; Claassen, Jurgen
   A.H.R./0000-0002-1778-8151; 
FU Donders TopTalent Grant - Netherlands Organisation for Scientific
   Research (NWO) [022-001-026]; Alzheimer Nederland [WE03-2010-03]; VIDI
   innovational grant from NWO [452-08-005]
FX This project was funded by a Donders TopTalent Grant supported by the
   Netherlands Organisation for Scientific Research (NWO) [no. 022-001-026]
   awarded to AV, and a grant from Alzheimer Nederland [no. WE03-2010-03]
   awarded to JC. RPCK was funded by a VIDI innovational grant from NWO
   [no. 452-08-005].
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NR 72
TC 42
Z9 45
U1 0
U2 41
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0960-2011
EI 1464-0694
J9 NEUROPSYCHOL REHABIL
JI Neuropsychol. Rehabil.
PD OCT-DEC
PY 2016
VL 26
IS 5-6
SI SI
BP 783
EP 809
DI 10.1080/09602011.2015.1048694
PG 27
WC Neurosciences; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychology
GA DR9WF
UT WOS:000380246100006
PM 26010573
DA 2023-08-17
ER

PT J
AU Reynolds, GO
   Willment, K
   Gale, SA
AF Reynolds, Gretchen O.
   Willment, Kim
   Gale, Seth A.
TI Mindfulness and Cognitive Training Interventions in Mild Cognitive
   Impairment: Impact on Cognition and Mood
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Review
DE Cognitive training; Mild cognitive impairment; Mindfulness
ID RANDOMIZED CONTROLLED-TRIAL; OLDER-ADULTS; STRESS REDUCTION;
   ALZHEIMERS-DISEASE; WORKING-MEMORY; MEDITATIONS IMPACT;
   PHYSICAL-EXERCISE; AEROBIC EXERCISE; RISK-FACTORS; DECLINE
AB With the lack of disease-modifying pharmacologic treatments for mild cognitive impairment and dementia, there has been an increasing clinical and research focus on nonpharmacological interventions for these disorders. Many treatment approaches, such as mindfulness and cognitive training, aim to mitigate or delay cognitive decline, particularly in early disease stages, while also offering potential benefits for mood and quality of life. In this review, we highlight the potential of mindfulness and cognitive training to improve cognition and mood in mild cognitive impairment. Emerging research suggests that these approaches are feasible and safe in this population, with preliminary evidence of positive effects on aspects of cognition (attention, psychomotor function, memory, executive function), depression, and anxiety, though some findings have been unclear or limited by methodological weaknesses. Even so, mindfulness and cognitive training warrant inclusion as current treatments for adults with mild cognitive impairment, even if there is need for additional research to clarify treatment outcomes and questions related to dose, mechanisms, and transfer and longevity of treatment effects. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Reynolds, Gretchen O.; Willment, Kim; Gale, Seth A.] Brigham & Womens Hosp, Dept Neurol, 60 Fenwood Rd, Boston, MA 02115 USA.
C3 Harvard University; Brigham & Women's Hospital
RP Reynolds, GO (corresponding author), Brigham & Womens Hosp, Dept Neurol, 60 Fenwood Rd, Boston, MA 02115 USA.
EM goreynolds@bwh.harvard.edu
OI Gale, Seth/0000-0003-2880-2112; Reynolds, Gretchen/0000-0003-4838-5096
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NR 122
TC 10
Z9 11
U1 8
U2 38
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD APR
PY 2021
VL 134
IS 4
BP 444
EP 455
DI 10.1016/j.amjmed.2020.10.041
EA APR 2021
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA RP7XN
UT WOS:000641938300011
PM 33385339
DA 2023-08-17
ER

PT J
AU McDougall, GJ
   McDonough, IM
   LaRocca, M
AF McDougall, Graham J.
   McDonough, Ian M.
   LaRocca, Michael
TI Memory training for adults with probable mild cognitive impairment: a
   pilot study
SO AGING & MENTAL HEALTH
LA English
DT Article
DE Memory training; randomized trial; mild cognitive impairment;
   minorities; Senior WISE
ID OLDER-ADULTS; FUNCTIONAL STATUS; ALZHEIMERS-DISEASE; AFRICAN-AMERICANS;
   TEST BATTERY; INTERVENTIONS; PERFORMANCE; DEPRESSION; HISPANICS;
   FRAMEWORK
AB Background & Objectives: This pilot study aimed to evaluate the efficacy of memory training and health training intervention over a 24-month period in people with probable mild cognitive impairment (MCI). Research Design & Methods: Based on the accepted criteria, and the neuropsychiatric measures used in the trial, MCI was defined as a subjective change in cognition, impairment in episodic memory, preservation of independence of functional abilities, and no dementia. Without a neurological assessment, laboratory tests, and psychometric evaluation combined, some of our participants may have had dementia that we were unable to detect through neuropsychological testing. Of the 263 total participants, 39 met criteria for a diagnosis of MCI. There were 19 adults in the memory and 20 in health training conditions. Both groups received twenty hours of classroom content that included eight hours of booster sessions at three months post intervention. Hierarchical linear models (HLM) and standardized regression-based (SBR) analyses were used to test the efficacy of the intervention on immediate recall, delayed recall, subjective memory complaints, and memory self-efficacy. Age, education, depression, racial group, ethnic group, MMSE score, and baseline performance were included as covariates. Results: Over 24 months, the MCI group in the memory training condition showed better objective and subjective memory outcomes compared with the MCI group in the health training condition. Conclusions: Senior WISE Memory training delivered to individuals with MCI was able to forestall the participants' declining cognitive ability and sustain the benefit over two years in both subjective and objective memory function.
C1 [McDougall, Graham J.] Florida State Univ, Coll Nursing, Tallahassee, FL 32306 USA.
   [McDonough, Ian M.] Univ Alabama, Dept Psychol, Box 870348, Tuscaloosa, AL 35487 USA.
   [LaRocca, Michael] Vet Adm Palo Alto Hlth Care Syst, War Related Illness & Injury Study Ctr, Livermore, CA USA.
C3 State University System of Florida; Florida State University; University
   of Alabama System; University of Alabama Tuscaloosa
RP McDougall, GJ (corresponding author), Florida State Univ, Coll Nursing, Tallahassee, FL 32306 USA.
EM gmcdougall@fsu.edu
RI McDonough, Ian M/O-9949-2015
OI McDonough, Ian M/0000-0003-0907-8931
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NR 47
TC 3
Z9 4
U1 1
U2 36
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD OCT 3
PY 2019
VL 23
IS 10
BP 1433
EP 1441
DI 10.1080/13607863.2018.1484884
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA IQ3FF
UT WOS:000480636100020
PM 30303394
OA Green Accepted
DA 2023-08-17
ER

PT J
AU De Marco, M
   Meneghello, F
   Pilosio, C
   Rigon, J
   Venneri, A
AF De Marco, Matteo
   Meneghello, Francesca
   Pilosio, Cristina
   Rigon, Jessica
   Venneri, Annalena
TI Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via
   Network based Cognitive Training
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Article
DE Mild cognitive impairment; cognitive stimulation; fMRI;
   neurodegenerative diseases; neuroplasticity; Alzheimer's disease;
   neuronal network remodelling
ID DEFAULT-MODE NETWORK; ALZHEIMERS-DISEASE; FUNCTIONAL CONNECTIVITY; BRAIN
   PLASTICITY; RESTING-STATE; MEMORY; STIMULATION; SUBTYPES; EXERCISE;
   ATROPHY
AB Background: Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network.
   Objective: In this study, the programme was administered to patients with a diagnosis of mild cognitive impairment to test its effects in a clinical sample.
   Method: Twenty-three patients with mild cognitive impairment (mean age: 73.74 years, standard deviation 5.13, female/male ratio 13/10) allocated to the experimental condition, underwent one month of computerised training, while fourteen patients (mean age: 73.14 years, standard deviation 6.16, female/male ratio 7/7) assigned to the control condition underwent a regime of intense social engagement. Patients were in the prodromal stage of Alzheimer's disease (AD) as confirmed by clinical follow ups for at least two years. The DMN was computed at baseline and retest, together with other, control patterns of connectivity, grey matter maps and neuropsychological profiles.
   Results: A condition-by-timepoint interaction indicating increased connectivity triggered by the programme was found in left parietal DMN regions. No decreases as well as no changes in the other networks or morphology were found. Although between-condition cognitive changes did not reach statistical significance, they correlated positively with changes in DMN connectivity in the left parietal region, supporting the hypothesis that parietal changes were beneficial.
   Conclusion: This programme of cognitive training up-regulates a pattern of connectivity which is pathologically down-regulated in AD. We argue that, when cognitive interventions are conceptualised as tools to induce co-activation repeatedly, they can lead to clinically relevant improvements in brain functioning, and can be of aid in support of pharmacological and other interventions in the earliest stages of AD.
C1 [De Marco, Matteo; Venneri, Annalena] Univ Sheffield, Dept Neurosci, Sheffield, S Yorkshire, England.
   [Meneghello, Francesca; Pilosio, Cristina; Rigon, Jessica] IRCCS Fdn Osped San Camillo, Venice Lido, Italy.
C3 N8 Research Partnership; White Rose University Consortium; University of
   Sheffield; IRCCS Ospedale San Camillo
RP Venneri, A (corresponding author), Univ Sheffield, Med Sch, Dept Neurosci, Royal Hallamshire Hosp, Beech Hill Rd, Sheffield S10 2RX, S Yorkshire, England.
EM a.venneri@sheffield.ac.uk
RI De Marco, Matteo/K-5698-2016; De Marco, Matteo/HLQ-7637-2023
OI De Marco, Matteo/0000-0002-9240-8067; De Marco,
   Matteo/0000-0002-9240-8067
FU Italian Ministry of Health [42/RF-2010-2321718]; European Union [601055]
FX This study was partially supported by grant No 42/RF-2010-2321718 by the
   Italian Ministry of Health and partial funding from the European Union
   Seventh Framework Programme (FP7/2007 2013) under grant agreement no.
   601055, VPH-DARE@IT to AV. As part of the STEPS procedures of
   hippocampal segmentation, the GPU card used for this research was
   donated by the NVIDIA Corporation. This is a summary of independent
   research canied out at the National Institute for Health Research (NIHR)
   Sheffield Biomedical Research Centre (Translational Neuroscience). The
   views expressed are those of the author(s) and not necessarily those of
   the NIHR or the Department of Health.
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NR 61
TC 18
Z9 18
U1 1
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PY 2018
VL 15
IS 6
BP 578
EP 589
DI 10.2174/1567205015666171212103323
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA GB9BD
UT WOS:000429368100008
PM 29231140
OA Green Accepted, Green Published, Green Submitted
DA 2023-08-17
ER

PT J
AU Yang, HY
   Leaver, AM
   Siddarth, P
   Paholpak, P
   Ercoli, L
   Cyr, NMS
   Eyre, HA
   Narr, KL
   Khalsa, DS
   Lavretsky, H
AF Yang, Hongyu
   Leaver, Amber M.
   Siddarth, Prabha
   Paholpak, Pattharee
   Ercoli, Linda
   Cyr, Natalie M. St.
   Eyre, Harris A.
   Narr, Katherine L.
   Khalsa, Dharma S.
   Lavretsky, Helen
TI Neurochemical and Neuroanatomical Plasticity Following Memory Training
   and Yoga Interventions in Older Adults with Mild Cognitive Impairment
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE proton magnetic resonance spectroscopy; structural magnetic resonance
   imaging; memory enhancement training; yogic meditation; dorsal anterior
   cingulate cortex; hippocampus
ID MAGNETIC-RESONANCE-SPECTROSCOPY; ALZHEIMERS-DISEASE;
   CEREBROSPINAL-FLUID; CORTICAL THICKNESS; BLOOD-FLOW; H-1 MRS; BRAIN;
   DEMENTIA; CHOLINE; PERFORMANCE
AB Behavioral interventions are becoming increasingly popular approaches to ameliorate age-related cognitive decline, but their underlying neurobiological mechanisms and clinical efficiency have not been fully elucidated. The present study explored brain plasticity associated with two behavioral interventions, memory enhancement training (MET) and a mind-body practice (yogic meditation), in healthy seniors with mild cognitive impairment (MCI) using structural magnetic resonance imaging (s-MRI) and proton magnetic resonance spectroscopy (H-1-MRS). Senior participants (age >55 years) with MCI were randomized to the MET or yogic meditation interventions. For both interventions, participants completed either MET training or Kundalini Yoga (KY) for 60-min sessions over 12 weeks, with 12-min daily homework assignments. Gray matter volume and metabolite concentrations in the dorsal anterior cingulate cortex (dACC) and bilateral hippocampus were measured by structural MRI and H-1-MRS at baseline and after 12 weeks of training. Metabolites measured included glutamate-glutamine (Glx), choline-containing compounds (Cho, including glycerophosphocholine and phosphocholine), gamma-aminobutyric acid (GABA), and N-acetyl aspartate and N-acetylaspartyl-glutamate (NM-NAAG). In total, 11 participants completed MET and 14 completed yogic meditation for this study. Structural MRI analysis showed an interaction between time and group in dACC, indicating a trend towards increased gray matter volume after the MET intervention. H-1-MRS analysis showed an interaction between time and group in choline-containing compounds in bilateral hippocampus, induced by significant decreases after the MET intervention. Though preliminary, our results suggest that memory training induces structural and neurochemical plasticity in seniors with MCI. Further research is needed to determine whether mind-body interventions like yoga yield similar neuroplastic changes.
C1 [Yang, Hongyu; Siddarth, Prabha; Paholpak, Pattharee; Ercoli, Linda; Cyr, Natalie M. St.; Eyre, Harris A.; Lavretsky, Helen] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA.
   [Leaver, Amber M.; Narr, Katherine L.] Univ Calif Los Angeles, Dept Neurol, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90024 USA.
   [Paholpak, Pattharee] Khon Kaen Univ, Fac Med, Dept Psychiat, Khon Kaen, Thailand.
   [Eyre, Harris A.] Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.
   [Eyre, Harris A.] Deakin Univ, Sch Med, IMPACT SRC, Geelong, Vic, Australia.
   [Eyre, Harris A.] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Khalsa, Dharma S.] Alzheimers Res & Prevent Fdn, Tucson, AZ USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   Khon Kaen University; University of Adelaide; Deakin University;
   University of Melbourne
RP Lavretsky, H (corresponding author), Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA.
EM hlavretsky@mednet.ucla.edu
RI Eyre, Harris/AAT-2457-2021
OI Eyre, Harris/0000-0003-4827-8258
FU Alzheimer's Research and Prevention Foundation (ARPF); National Alliance
   for Research on Schizophrenia and Depression (NARSAD) Young Investigator
   Grant from the Brain and Behavior Research Foundation [22325]
FX This study was supported by the Alzheimer's Research and Prevention
   Foundation (ARPF), and 2014 National Alliance for Research on
   Schizophrenia and Depression (NARSAD) Young Investigator Grant from the
   Brain and Behavior Research Foundation (22325).
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NR 78
TC 31
Z9 33
U1 1
U2 50
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD NOV 21
PY 2016
VL 8
AR 277
DI 10.3389/fnagi.2016.00277
PG 9
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA EC4TS
UT WOS:000388127500001
PM 27917121
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Burgio, F
   Delazer, M
   Meneghello, F
   Pertl, MT
   Semenza, C
   Zamarian, L
AF Burgio, Francesca
   Delazer, Margarete
   Meneghello, Francesca
   Pertl, Marie-Theres
   Semenza, Carlo
   Zamarian, Laura
TI Cognitive Training Improves Ratio Processing and Decision Making in
   Patients with Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Executive functions; intervention; medical information; neuropsychology;
   numerical processing
ID EXPLICIT RISK CONDITIONS; EXECUTIVE FUNCTIONS; ALZHEIMERS-DISEASE;
   OLDER-ADULTS; DICE TASK; NUMERACY; FEEDBACK; MEMORY; STRATEGIES;
   ABILITIES
AB Background: Patients with mild cognitive impairment (MCI) show lower decision making and ratio processing abilities as compared to healthy peers.
   Objective: To evaluate whether cognitive training on number processing and/or executive functions improves performance on ratio processing and decision making under risk.
   Methods: In a controlled cross-over study, patients with MCI (n= 23; mean MMSE 26.48, SD 2.43) underwent a week of numerical training followed by a week of executive-functions training (subgroup A), or vice versa (subgroup B). Before training (T1), patients performed experimental tasks of decision making (Game of Dice Task, GDT; Probability-Associated Gambling task, PAG-60 task) and of ratio processing as well as a neuropsychological background assessment. Experimental tasks were also administered after the first (T2) and the second (T3) training week.
   Results: The numerical training and the training of executive functions had a differential effect on experimental tasks of ratio processing. Only the numerical training proved to be effective. The effects of the two training types on decision making under risk were less clear-cut. While no changes over time were observed in the GDT, performance on the PAG-60 task improved in both training subgroups. These improvements were apparent in one subgroup after a period of executive-functions training, in the other subgroup after both training weeks. That means, improvements are not attributable to one specific training type.
   Conclusion: Patients with MCI can profit from a cognitive training on number processing and executive functions. Improvements are reflected in higher ratio processing abilities and more advantageous decisions after training. These results are consistent with assumptions of current cognitive models.
C1 [Burgio, Francesca; Meneghello, Francesca; Semenza, Carlo] San Camillo Hosp IRCCS, Venice, Italy.
   [Delazer, Margarete; Pertl, Marie-Theres; Zamarian, Laura] Med Univ Innsbruck, Dept Neurol, Anichstr 35, A-6020 Innsbruck, Austria.
   [Semenza, Carlo] Univ Padua, Padova Neurosci Ctr, Dept Neurosci, Padua, Italy.
C3 IRCCS Ospedale San Camillo; Medical University of Innsbruck; ARQUS;
   University of Padua
RP Zamarian, L (corresponding author), Med Univ Innsbruck, Dept Neurol, Anichstr 35, A-6020 Innsbruck, Austria.
EM laura.zamarian@i-med.ac.at
RI Zamarian, Laura/J-9575-2018; Burgio, Francesca/J-9562-2018
OI Zamarian, Laura/0000-0002-1640-4179; Burgio,
   Francesca/0000-0003-2730-228X; Delazer, Margarete/0000-0001-6482-4445
FU San Camillo Hospital IRCCS, Venice, Italy; Medical University of
   Innsbruck, Austria [2014-05-001]
FX This work was supported by San Camillo Hospital IRCCS, Venice, Italy,
   and by Medical University of Innsbruck, Austria (MUI-Start 2014-05-001).
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NR 59
TC 13
Z9 13
U1 0
U2 13
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2018
VL 64
IS 4
BP 1213
EP 1226
DI 10.3233/JAD-180461
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA GO0CM
UT WOS:000439588200014
PM 30010137
DA 2023-08-17
ER

PT J
AU Li, BY
   Tang, HD
   He, GY
   Jin, ZJ
   He, YX
   Huang, P
   He, NY
   Chen, SD
AF Li, Binyin
   Tang, Huidong
   He, Guiying
   Jin, Zhijia
   He, Yixi
   Huang, Pei
   He, Naying
   Chen, Shengdi
TI Tai Chi enhances cognitive training effects on delaying cognitive
   decline in mild cognitive impairment
SO ALZHEIMERS & DEMENTIA
LA English
DT Article
DE cognitive training; mild cognitive impairment; mixed training; Tai Chi
   exercise
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; WORKING-MEMORY; DEMENTIA;
   INTERVENTION; PERFORMANCE; FRAMEWORK; PROGRAM; IMPACT
AB Introduction Cognitive training and physical exercise have shown positive effects on delaying progression of mild cognitive impairment (MCI) to dementia. Methods We explored the enhancing effect from Tai Chi when it was provided with cognitive training for MCI. In the first 12 months, the cognitive training group (CT) had cognitive training, and the mixed group (MixT) had additional Tai Chi training. In the second 12 months, training was only provided for a subgroup of MixT. Results In the first 12 months, MixT and CT groups were benefited from training. Compared to the CT group, MixT had additional positive effects with reference to baseline. In addition, Compared to short-time training, prolonged mixed training further delayed decline in global cognition and memory. Functional magnetic resonance imaging showed more increased regional activity in both CT and MixT. Discussion Tai Chi enhanced cognitive training effects in MCI. Moreover, Tai Chi and cognitive mixed training showed effects on delaying cognitive decline.
C1 [Li, Binyin; Tang, Huidong; He, Guiying; He, Yixi; Huang, Pei; Chen, Shengdi] Shanghai Jiao Tong Univ, Dept Neurol, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China.
   [Li, Binyin; Tang, Huidong; He, Guiying; He, Yixi; Huang, Pei; Chen, Shengdi] Shanghai Jiao Tong Univ, Inst Neurol, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China.
   [Jin, Zhijia; He, Naying] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Radiol, Sch Med, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University
RP Chen, SD (corresponding author), Shanghai Jiao Tong Univ, Dept Neurol, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China.; Chen, SD (corresponding author), Shanghai Jiao Tong Univ, Inst Neurol, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China.
EM chensd@rjh.com.cn
FU Shanghai Municipal Science and Technology Major Project Grant
   [2018SHZDZX05]; Innovation Program of Shanghai Municipal Education
   Commission [2017-01-07-00-01-E00046]; Clinical Research Center, Shanghai
   Jiao Tong University School of Medicine [DLY201603]; National Key R&D
   Program of China [2016YFC1305804]; Shanghai Rising-Star Program
   [21QA1405800]
FX We thank all the patients who participated in this study. We also thank
   all the coaches of Sino Taiji of Fuxing International for their Tai Chi
   training courses to the patients. The trial is supported by the Shanghai
   Municipal Science and Technology Major Project Grant (2018SHZDZX05),
   Innovation Program of Shanghai Municipal Education Commission
   (2017-01-07-00-01-E00046), Clinical Research Center, Shanghai Jiao Tong
   University School of Medicine (DLY201603), National Key R&D Program of
   China (2016YFC1305804), and Shanghai Rising-Star Program (21QA1405800).
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NR 46
TC 3
Z9 3
U1 28
U2 55
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-5260
EI 1552-5279
J9 ALZHEIMERS DEMENT
JI Alzheimers. Dement.
PD JAN
PY 2023
VL 19
IS 1
BP 136
EP 149
DI 10.1002/alz.12658
EA MAR 2022
PG 14
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 8K3KB
UT WOS:000769058800001
PM 35290704
DA 2023-08-17
ER

PT J
AU Li, BY
   He, NY
   Qiao, Y
   Xu, HM
   Lu, YZ
   Cu, PJ
   Ling, HW
   Yan, FH
   Tang, HD
   Chen, SD
AF Li, Bin-Yin
   He, Na-Ying
   Qiao, Yuan
   Xu, Hong-Min
   Lu, Yi-Zhou
   Cu, Pei-Jing
   Ling, Hua-Wei
   Yan, Fu-Hua
   Tang, Hui-Dong
   Chen, Sheng-Di
TI Computerized cognitive training for Chinese mild cognitive impairment
   patients: A neuropsychological and fMRI study
SO NEUROIMAGE-CLINICAL
LA English
DT Article
DE Mild cognitive impairment; Cognitive therapy; Neuroimaging;
   Neuropsychology
ID FREQUENCY FLUCTUATION ALFF; ALZHEIMERS-DISEASE; OLDER-ADULTS; INSULAR
   CORTEX; MEMORY; INTERVENTION; AMPLITUDE; DEMENTIA; IMPACT;
   REPRESENTATIONS
AB Background: Computerized multi-model training has been widely studied for its effect on delaying cognitive decline. In this study, we designed the first Chinese-version computer-based multi-model cognitive training for mild cognitive impairment (MCI) patients. Neuropsychological effects and neural activity changes assessed by functional MRI were both evaluated.
   Method: MCI patients in the training group were asked to take training 3-4 times per week for 6 months. Neuropsychological and resting-state fMRI assessment were performed at baseline and at 6 months. Patients in both groups were continuously followed up for another 12 months and assessed by neuropsychological tests again.
   Results: 78 patients in the training group and 63 patients in the control group accomplished 6-month follow-up. Training group improved 0.23 standard deviation (SD) of mini-mental state examination, while control group had 0.5 SD decline. Addenbrooke's cognitive examination-revised scores in attention (p = 0.002) and memory (p = 0.006), as well as stroop color-word WA interference index (p = 0.038) and complex figure test-copy score (p = 0.035) were also in favor of the training effect. Difference between the changes of two groups after training was not statistically significant. The fMRI showed increased regional activity at bilateral temporal poles, insular cortices and hippocampus. However, difference between the changes of two groups after another 12 months was not statistically significant.
   Conclusions: Multi-model cognitive training help MCI patients to gained cognition benefit, especially in memory, attention and executive function. Functional neuroimaging provided consistent neural activation evidence. Nevertheless, after one-year follow up after last training, training effects were not significant. The study provided new evidence of beneficial effect of multi-model cognitive training.
C1 [Li, Bin-Yin; Qiao, Yuan; Lu, Yi-Zhou; Tang, Hui-Dong; Chen, Sheng-Di] Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Dept Neurol, Shanghai 200025, Peoples R China.
   [Li, Bin-Yin; Qiao, Yuan; Lu, Yi-Zhou; Tang, Hui-Dong; Chen, Sheng-Di] Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Inst Neurol, Shanghai 200025, Peoples R China.
   [He, Na-Ying; Xu, Hong-Min; Ling, Hua-Wei; Yan, Fu-Hua] Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Dept Radiol, Shanghai 200025, Peoples R China.
   [Cu, Pei-Jing] Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Dept Geriatr, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University; Shanghai Jiao Tong University
RP Yan, FH; Tang, HD; Chen, SD (corresponding author), 197 Rui Jin Rd 2, Shanghai, Peoples R China.
EM yfh11655@rjh.com.cn; funground@163.com; chensd@rjh.com.cn
FU Clinical Research Center, Shanghai Jiao Tong University School of
   Medicine [DLY201603]; National Natural Science Foundation of China
   [81501086, 81400888, 91332107]; National Key R&D Program of China
   [2016YFC1305804]; Innovation Program of Shanghai Municipal Education
   Commission [2017-01-07-00-01-E00046]
FX This work was supported by grants from Clinical Research Center,
   Shanghai Jiao Tong University School of Medicine [DLY201603]; the
   National Natural Science Foundation of China [81501086, 81400888,
   91332107]; National Key R&D Program of China [2016YFC1305804]; and
   Innovation Program of Shanghai Municipal Education Commission
   [2017-01-07-00-01-E00046].
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NR 53
TC 22
Z9 25
U1 3
U2 31
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-1582
J9 NEUROIMAGE-CLIN
JI NeuroImage-Clin.
PY 2019
VL 22
AR 101691
DI 10.1016/j.nicl.2019.101691
PG 8
WC Neuroimaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA IB2UA
UT WOS:000470123000008
PM 30708349
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Sheng, Y
   Li, Z
   Hao, Y
   Li, A
   Jing, J
AF Sheng, Y.
   Li, Z.
   Hao, Y.
   Li, A.
   Jing, J.
TI IMPACT OF MEMORY FOR AMNESTIC MILD COGNITIVE IMPAIRMENT ELDERLY PEOPLE
   BY MEMORY TRAINING
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Sheng, Y.; Li, Z.; Jing, J.] Peking Union Med Coll, Sch Nursing, Basic Nursing, Beijing 100021, Peoples R China.
   [Hao, Y.; Li, A.] Fang Zhuang Hlth Community Serv Ctr, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; School of Nursing - PUMC
RI SHENG, Yu/GXZ-8269-2022
NR 0
TC 0
Z9 0
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
EI 1758-5341
J9 GERONTOLOGIST
JI Gerontologist
PD NOV
PY 2015
VL 55
SU 2
BP 422
EP 422
PG 1
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA DJ5BV
UT WOS:000374222702154
DA 2023-08-17
ER

PT J
AU Smith, L
   Argentina, V
AF Smith, Lenora
   Argentina, Vinny
TI The Usability of Physical Activity and Cognitive Training Applications
   in People With Mild Cognitive Impairment
SO RESEARCH IN GERONTOLOGICAL NURSING
LA English
DT Article
ID DWELLING OLDER-ADULTS; QUALITY-OF-LIFE; AEROBIC EXERCISE; ASSISTIVE
   TECHNOLOGIES; DEMENTIA; HEALTH; ACCEPTABILITY; INTERVENTIONS;
   PERFORMANCE; OUTCOMES
AB The aim of the current study is to identify key issues with utility, effectiveness, and appeal of specific electronic applications (apps) for people with mild cognitive impairment (MCI) to guide the design and development of a mobile app, which integrates physical activity and cognitive activities. Sixteen partici- pants age >= 6 were recruited from three assisted living facilities in Alabama. Participants were observed playing a physical activity app and cognitive training app via a tablet on two separate occasions. Most participants agreed that Sworki (R), Elevate (R), and 7-Minute Workout (R) were easy to use and fun, less frustrating, and they would recommend them to a friend. Most participants had questions regarding clarification about how to play the games. All (100%) participants smiled and appeared happy when playing the physical activity games, whereas only 35% smiled during the cognitive training games. The current study was instrumental in revealing that people with MCI can use technology and provide feedback regarding use of that technology. Individuals with impaired cognition should be recruited for participation in research for the knowledge they can provide researchers.
C1 [Smith, Lenora] Univ Alabama, Coll Nursing, 309 Sparkman Dr,NB 209D, Huntsville, AL 35899 USA.
   [Argentina, Vinny] Univ Alabama, Coll Arts Humanities & Social Sci, Huntsville, AL 35899 USA.
C3 University of Alabama System; University of Alabama Huntsville;
   University of Alabama System; University of Alabama Huntsville
RP Smith, L (corresponding author), Univ Alabama, Coll Nursing, 309 Sparkman Dr,NB 209D, Huntsville, AL 35899 USA.
EM lws0003@uah.edu
FU University of Alabama in Huntsville, New Faculty Research Grant
FX The authors have disclosed no potential conflicts of interest, financial
   or otherwise. Funding for this study was provided by the University of
   Alabama in Huntsville, New Faculty Research Grant.
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NR 61
TC 4
Z9 4
U1 1
U2 23
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 1940-4921
EI 1938-2464
J9 RES GERONTOL NURS
JI Res. Gerontol. Nurs.
PD MAR-APR
PY 2020
VL 13
IS 2
BP 64
EP 72
DI 10.3928/19404921-20190930-04
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA KW0LA
UT WOS:000520864000002
PM 31584688
OA Green Published
DA 2023-08-17
ER

PT J
AU Zhang, H
   Wang, J
   Wang, Z
   Wang, X
   Yu, X
   Wang, H
AF Zhang, H.
   Wang, J.
   Wang, Z.
   Wang, X.
   Yu, X.
   Wang, H.
TI EFFECT OF TABLET-BASED MULTI-DOMAIN COGNITIVE TRAINING ON BRAIN FUNCTION
   IN MILD COGNITIVE IMPAIRMENT
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Zhang, H.; Wang, J.; Wang, Z.; Wang, X.; Yu, X.; Wang, H.] Peking Univ, Inst Mental Hlth, Hosp 6, Dementia Care & Res Ctr, Beijing 100871, Peoples R China.
   [Zhang, H.; Wang, J.; Wang, Z.; Wang, X.; Yu, X.; Wang, H.] Natl Clin Res Ctr Mental Disorders, Beijing Municipal Key Lab Translat Res Diag & Tre, Beijing, Peoples R China.
C3 Peking University
NR 0
TC 0
Z9 0
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2016
VL 50
SU 1
BP 27
EP 27
PG 1
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DL4GI
UT WOS:000375591600054
DA 2023-08-17
ER

PT J
AU Finn, M
   McDonald, S
AF Finn, Maurice
   McDonald, Skye
TI A single case study of computerised cognitive training for older persons
   with mild cognitive impairment
SO NEUROREHABILITATION
LA English
DT Article
DE Aged; cognitive training; mild cognitive impairment; single case study
ID REHABILITATION PROGRAM; ALZHEIMERS-DISEASE; OUTCOMES; MEMORY; ADULTS
AB The results of a multiple baseline single case study using computerised cognitive training in older adults with Amnestic Mild Cognitive Impairment (aMCI) are reported. Two participants each completed 40 sessions of training in two phases: an initial phase that trained attention, processing speed and cognitive flexibility, followed by a mixed memory and execution functions phase. It was hypothesised that participants would improve with practice on the trained tasks, that the benefits of training would generalise to non-trained neuropsychological probe measures, and that training would result in improved perceptions of memory and mood. Results indicated that one participant showed improved performance on untrained measures of attention and reasoning. On pre/post measures both participants reported less frequent cognitive failures in everyday life and improved mood following training. The results are discussed along with suggestions for future research.
C1 [Finn, Maurice; McDonald, Skye] Univ New S Wales, Sch Psychol, Sydney, NSW, Australia.
C3 University of New South Wales Sydney
RP Finn, M (corresponding author), Royal N Shore Hosp, Aged Care Memory Clin, 2C Herbert St, St Leonards, NSW 2065, Australia.
EM mefinn@nsccahs.health.nsw.gov.au
RI McDonald, Skye/G-4118-2014
OI McDonald, Skye/0000-0003-0723-6094
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   Winblad B, 2004, J INTERN MED, V256, P240, DOI 10.1111/j.1365-2796.2004.01380.x
NR 26
TC 7
Z9 7
U1 0
U2 16
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1053-8135
EI 1878-6448
J9 NEUROREHABILITATION
JI Neurorehabilitation
PY 2014
VL 35
IS 2
BP 261
EP 270
DI 10.3233/NRE-141121
PG 10
WC Clinical Neurology; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Rehabilitation
GA AQ7OE
UT WOS:000343007000011
PM 24990031
DA 2023-08-17
ER

PT J
AU Nakawiro, D
   Chansirikarnjana, S
   Srisuwan, P
   Aebthaisong, O
   Sudsakorn, P
   Vidhyachak, C
   Visajan, P
AF Nakawiro, D.
   Chansirikarnjana, S.
   Srisuwan, P.
   Aebthaisong, O.
   Sudsakorn, P.
   Vidhyachak, C.
   Visajan, P.
TI Cognitive stimulation and cognitive training program in mild cognitive
   impairment (MCI)
SO ASIA-PACIFIC PSYCHIATRY
LA English
DT Meeting Abstract
C1 [Nakawiro, D.; Vidhyachak, C.; Visajan, P.] Mahidol Univ, Ramathibodi Hosp, Dept Psychiat, Bangkok 10700, Thailand.
   [Chansirikarnjana, S.] Mahidol Univ, Ramathibodi Hosp, Dept Med, Bangkok 10700, Thailand.
   [Srisuwan, P.] Phramongkutklao Coll Med, Dept Family Med, Bangkok, Thailand.
   [Aebthaisong, O.] Srithanya Hosp, Nonthaburi, Thailand.
   [Sudsakorn, P.] Mahidol Univ, Siriraj Hosp, Dept Psychiat, Bangkok, Thailand.
C3 Mahidol University; Mahidol University; Phramongkutklao College of
   Medicine; Mahidol University
NR 0
TC 0
Z9 0
U1 2
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1758-5864
EI 1758-5872
J9 ASIA-PAC PSYCHIAT
JI Asia-Pac. Psychiatry
PD JUN
PY 2015
VL 7
SU 1
SI SI
MA 80
BP 23
EP 23
PG 1
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CT0SD
UT WOS:000362505800037
DA 2023-08-17
ER

PT J
AU Araujo, JA
   Studzinski, CM
   Head, E
   Cotman, CW
   Milgram, NW
AF Araujo, Joseph A.
   Studzinski, Christa M.
   Head, Elizabeth
   Cotman, Carl W.
   Milgram, Norton W.
TI Assessment of nutritional interventions for modification of
   age-associated cognitive decline using a canine model of human aging
SO AGE
LA English
DT Review
DE aging; Alzheimer's disease; antioxidants; brain pathology; canine model;
   cognitive dysfunction; docosahexaenoic acid; mitochondrial cofactors;
   nutritional interventions; phospholipids
ID NEURONAL SIGNAL-TRANSDUCTION; BETA-AMYLOID ACCUMULATION; DOCOSAHEXAENOIC
   ACID; ALZHEIMERS-DISEASE; OXIDATIVE DAMAGE; LEARNING-ABILITY; BEAGLE
   DOGS; VITAMIN-E; NEURODEGENERATIVE DISEASES; ANTIOXIDANT SUPPLEMENTS
AB The present review focuses on the utility of a canine model in evaluating nutritional interventions for age-related cognitive dysfunction. Aged dogs demonstrate progressive cognitive decline with concurrent amyloid-beta pathology that parallels the pathology observed in aging humans. Dogs, therefore, provide a natural model of human pathological aging. We have and are in the process of evaluating several nutritional-based interventions aimed at preventing cognitive decline and brain aging. In a three-year longitudinal study, we examined the effects of a diet enriched with antioxidants and mitochondrial cofactors on several measures of cognition and brain aging. Compared to controls, aged dogs on the enriched diet demonstrated both short- and long-term cognitive benefits, as well decreased deposition of amyloid-beta protein. The diet also reduced behavioral signs associated with canine Cognitive Dysfunction Syndrome when assessed in veterinary clinical trials. We also have preliminary evidence suggesting a beneficial effect of a proprietary blend of docosahexaenoic acid and phospholipids on both cognitive and physiological measures. Collectively, our data indicate (1) that the dog, either in the laboratory or in the clinic, provides an important tool for assessing nutritional interventions and (2) that combination interventions aimed at several mechanisms of pathological aging may prove more effective than single nutritive components in human trials.
C1 Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
   Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA.
   Univ Toronto, Div Life Sci, Scarborough, ON M1C 1A4, Canada.
C3 University of Toronto; University of California System; University of
   California Irvine; University of Toronto; University Toronto Scarborough
RP Milgram, NW (corresponding author), Univ Toronto, Dept Pharmacol, Med Sci Bldg, Toronto, ON, Canada.
EM milgram@utsc.utoronto.ca
OI Studzinski, Christa/0009-0004-8513-0337
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NR 90
TC 21
Z9 25
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
J9 AGE
JI Age
PD MAR
PY 2005
VL 27
IS 1
BP 27
EP 37
DI 10.1007/s11357-005-4001-z
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 121FO
UT WOS:000243143700005
PM 23598601
OA Green Published
DA 2023-08-17
ER

PT J
AU Ge, SQ
   Zhu, Z
   Wu, B
   McConnell, ES
AF Ge, Shaoqing
   Zhu, Zheng
   Wu, Bei
   McConnell, Eleanor S.
TI Technology-based cognitive training and rehabilitation interventions for
   individuals with mild cognitive impairment: a systematic review
SO BMC GERIATRICS
LA English
DT Review
DE Technology; Cognition; Cognitive training; Cognitive rehabilitation;
   Systematic review
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; PROGRAM; DEMENTIA; MEMORY; RISK;
   EFFICACY; DEFICITS; HEALTHY
AB Background: Individuals with mild cognitive impairment (MCI) are at heightened risk of developing dementia. Rapid advances in computing technology have enabled researchers to conduct cognitive training and rehabilitation interventions with the assistance of technology. This systematic review aims to evaluate the effects of technology-based cognitive training or rehabilitation interventions to improve cognitive function among individuals with MCI.
   Methods: We conducted a systematic review using the following criteria: individuals with MCI, empirical studies, and evaluated a technology-based cognitive training or rehabilitation intervention. Twenty-six articles met the criteria.
   Results: Studies were characterized by considerable variation in study design, intervention content, and technologies applied. The major types of technologies applied included computerized software, tablets, gaming consoles, and virtual reality. Use of technology to adjust the difficulties of tasks based on participants' performance was an important feature. Technology-based cognitive training and rehabilitation interventions had significant effect on global cognitive function in 8 out of 22 studies; 8 out of 18 studies found positive effects on attention, 9 out of 16 studies on executive function, and 16 out of 19 studies on memory. Some cognitive interventions improved non-cognitive symptoms such as anxiety, depression, and ADLs.
   Conclusion: Technology-based cognitive training and rehabilitation interventions show promise, but the findings were inconsistent due to the variations in study design. Future studies should consider using more consistent methodologies. Appropriate control groups should be designed to understand the additional benefits of cognitive training and rehabilitation delivered with the assistance of technology.
C1 [Ge, Shaoqing; McConnell, Eleanor S.] Duke Univ, Sch Nursing, 307 Trent Dr, Durham, NC 27708 USA.
   [Zhu, Zheng] Fudan Univ, Sch Nursing, Shanghai, Peoples R China.
   [Zhu, Zheng] Fudan Univ, Ctr Evidence Based Nursing, Shanghai, Peoples R China.
   [Wu, Bei] NYU, Rory Meyers Coll Nursing, New York, NY USA.
   [Wu, Bei] NYU, Hartford Inst Geriatr Nursing, New York, NY USA.
   [McConnell, Eleanor S.] Dept Vet Affairs Med Ctr, GRECC, Durham, NC USA.
C3 Duke University; Fudan University; Fudan University; New York
   University; New York University; Geriatric Research Education & Clinical
   Center
RP Ge, SQ (corresponding author), Duke Univ, Sch Nursing, 307 Trent Dr, Durham, NC 27708 USA.
EM shaoqing.ge@duke.edu
RI McConnell, Eleanor/AAO-5920-2020; Wu, Bei/X-2404-2019; Zhu,
   Zheng/AGE-0902-2022
OI McConnell, Eleanor/0000-0002-2896-8596; Wu, Bei/0000-0002-6891-244X;
   Zhu, Zheng/0000-0001-9651-8311; Ge, Shaoqing/0000-0003-2436-5760
CR [Anonymous], 2016, WORLD ALZH REP 2016
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NR 47
TC 70
Z9 74
U1 6
U2 55
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD SEP 15
PY 2018
VL 18
AR 213
DI 10.1186/s12877-018-0893-1
PG 19
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GT6TY
UT WOS:000444654400001
PM 30219036
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Hung, SCW
   Ho, AYN
   Lai, IHW
   Lee, CSW
   Pong, ASK
   Lai, FHY
AF Hung, Sarah Chui-Wai
   Ho, Annie Yin-Ni
   Lai, Idy Hiu-Wai
   Lee, Carol Sze-Wing
   Pong, Angela Shuk-Kwan
   Lai, Frank Ho-Yin
TI Meta-Analysis on the Effectiveness of Virtual Reality Cognitive Training
   (VRCT) and Computer-Based Cognitive Training (CBCT) for Individuals with
   Mild Cognitive Impairment (MCI)
SO ELECTRONICS
LA English
DT Review
DE mild cognitive impairment; virtual reality; computer; cognitive
   training; meta-analysis
ID OLDER-ADULTS; EXECUTIVE FUNCTION; WORKING-MEMORY; DEMENTIA; PROGRAM;
   LANGUAGE
AB This meta-analysis aims to assess the effectiveness of virtual reality cognitive training (VRCT) and conventional computer-based cognitive training (CBCT) in five specific cognitive domains (i.e., global cognitive function (GCF), memory (Mem), executive function (EF), language (Lang) and visuospatial skills (VS)) of individuals with mild cognitive impairment. A total of 320 studies were yielded from five electronic databases. Eighteen randomized controlled trials met the PRISMA criteria, with 10 related to VRCT and 8 related to CBCT. A random-effect model was used in determining the main effect of cognitive training in five specific cognitive domains. VRCT provided the largest effect size on VS and Lang while the smallest on EF. CBCT provided the largest effect size on Mem and Lang while the smallest on EF. VRCT and CBCT generate an opposite effect on VS. VRCT outweighs CBCT in treatment effectiveness of GCF, EF, Lang and VS. More immersive and interactive experiences in VRCT may help individuals with MCI better engage in real-life experiences, which supports skill generalization and reduces external distractions. CBCT tends to improve Mem but no definite conclusions can be made. Further investigation with more stringent research design and specific protocol are required to reach consensus about the optimum intervention regime.
C1 [Hung, Sarah Chui-Wai; Ho, Annie Yin-Ni; Lai, Idy Hiu-Wai; Lee, Carol Sze-Wing; Pong, Angela Shuk-Kwan; Lai, Frank Ho-Yin] Hong Kong Polytech Univ, Dept Rehabil Sci, Hung Hom, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University
RP Lai, FHY (corresponding author), Hong Kong Polytech Univ, Dept Rehabil Sci, Hung Hom, Hong Kong, Peoples R China.
EM 17052851d@connect.polyu.hk; 17052478d@connect.polyu.hk;
   17057306d@connect.polyu.hk; 17049607d@connect.polyu.hk;
   17049927d@connect.polyu.hk; frank.hy.lai@polyu.edu.hk
RI Lai, Frank Ho-yin/AAD-8723-2021; Ho, Annie/IRZ-2047-2023
OI Lai, Frank Ho-yin/0000-0003-0365-7000; Hung, Sarah Chui
   Wai/0000-0002-6606-597X; Ho, Yin Ni/0000-0002-3448-1397; Pong, Shuk
   Kwan/0000-0002-6169-0864
FU Innovation and Technology Fund for Better Living in the Hong Kong
   Special Administrative Region [ITB/FBL/2004/19/P]
FX This study was supported by Innovation and Technology Fund for Better
   Living in the Hong Kong Special Administrative Region
   (ITB/FBL/2004/19/P).
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NR 47
TC 3
Z9 3
U1 5
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-9292
J9 ELECTRONICS-SWITZ
JI Electronics
PD DEC
PY 2020
VL 9
IS 12
AR 2185
DI 10.3390/electronics9122185
PG 17
WC Computer Science, Information Systems; Engineering, Electrical &
   Electronic; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Computer Science; Engineering; Physics
GA PK0IT
UT WOS:000602139900001
OA gold, Green Accepted
DA 2023-08-17
ER

PT J
AU Park, E
   Yun, BJ
   Min, YS
   Lee, YS
   Moon, SJ
   Huh, JW
   Cha, H
   Chang, Y
   Jung, TD
AF Park, Eunhee
   Yun, Byoung-Ju
   Min, Yu-Sun
   Lee, Yang-Soo
   Moon, Sung-Jun
   Huh, Jae-Won
   Cha, Hyunsil
   Chang, Yongmin
   Jung, Tae-Du
TI Effects of a Mixed Reality-based Cognitive Training System Compared to a
   Conventional Computer-assisted Cognitive Training System on Mild
   Cognitive Impairment: A Pilot Study
SO COGNITIVE AND BEHAVIORAL NEUROLOGY
LA English
DT Article
DE mixed reality; virtual reality; cognitive rehabilitation; mild cognitive
   impairment
ID VIRTUAL-REALITY; OLDER-ADULTS; DEMENTIA; REHABILITATION; MEMORY;
   BENEFITS; PEOPLE; STROKE
AB Background: Mixed reality (MR) technology, which combines the best features of augmented reality and virtual reality, has recently emerged as a promising tool in cognitive rehabilitation therapy. Objective: To investigate the effectiveness of an MR-based cognitive training system for individuals with mild cognitive impairment (MCI). Methods: Twenty-one individuals aged 65 years and older who had been diagnosed with MCI were recruited for this study and were divided into two groups. Participants in the MR group (n=10, aged 70.5 +/- 4.2 years) received 30 minutes of training 3 times a week for 6 weeks using a newly developed MR-based cognitive training system. Participants in the control group (n=11, aged 72.6 +/- 5.3 years) received the same amount of training using a conventional computer-assisted cognitive training system. Both groups took the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) both before and after intervention. To determine the effect of the intervention on cognitive function, we compared the difference in each group's CERAD-K scores. Results: There was a statistically significant interaction between intervention (MR group vs control group) and time (before vs after intervention) as assessed by the Constructional Recall Test. The individuals with MCI who participated in the MR training showed significantly improved performance in visuospatial working memory compared with the individuals with MCI who participated in the conventional training. Conclusion: An MR-based cognitive training system can be used as a cognitive training tool to improve visuospatial working memory in individuals with MCI.
C1 [Park, Eunhee; Min, Yu-Sun; Lee, Yang-Soo; Moon, Sung-Jun; Huh, Jae-Won; Jung, Tae-Du] Kyungpook Natl Univ, Dept Rehabil Med, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea.
   [Park, Eunhee; Min, Yu-Sun] Kyungpook Natl Univ, Dept Rehabil Med, Sch Med, Daegu, South Korea.
   [Chang, Yongmin] Kyungpook Natl Univ, Dept Radiol, Sch Med, Daegu, South Korea.
   [Chang, Yongmin] Kyungpook Natl Univ, Dept Mol Med, Sch Med, Daegu, South Korea.
   [Yun, Byoung-Ju] Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu, South Korea.
   [Cha, Hyunsil; Chang, Yongmin] Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu, South Korea.
   [Lee, Yang-Soo; Huh, Jae-Won; Jung, Tae-Du] Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu, South Korea.
C3 Kyungpook National University; Kyungpook National University; Kyungpook
   National University; Kyungpook National University; Kyungpook National
   University; Kyungpook National University; Kyungpook National
   University; Kyungpook National University Hospital
RP Jung, TD (corresponding author), Kyungpook Natl Univ, Dept Rehabil Med, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea.
EM teeed0522@hanmail.net
OI Moon, Sung-Jun/0000-0003-4232-8680
CR [Anonymous], J KOREAN NEUROPSYCHI
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NR 43
TC 22
Z9 23
U1 4
U2 33
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1543-3633
EI 1543-3641
J9 COGN BEHAV NEUROL
JI Cogn. Behav. Neurol.
PD SEP
PY 2019
VL 32
IS 3
BP 172
EP 178
DI 10.1097/WNN.0000000000000197
PG 7
WC Behavioral Sciences; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA JE1VK
UT WOS:000490483700003
PM 31517700
DA 2023-08-17
ER

PT J
AU Oh, MW
   Ki, YJ
   Jeon, BH
   Kim, SY
   Oh, Y
   Yoo, S
   Cho, A
   Seo, JH
   Lee, GJ
AF Oh, Min Woo
   Ki, Young Jin
   Jeon, Byoung Hyun
   Kim, Si Yeon
   Oh, Youngmin
   Yoo, Suwon
   Cho, Aeri
   Seo, Joo Han
   Lee, Goo Joo
TI Nurse-Led Computerized Cognitive Training for Mild Cognitive Impairment:
   A Preliminary Study
SO REHABILITATION NURSING
LA English
DT Article
DE Attention; cognitive dysfunction; memory; nurses; rehabilitation
ID OLDER-ADULTS; DEMENTIA; QUESTIONNAIRE; VERSION; BLIND; TRIAL; SCALE
AB Purpose
   This preliminary study aimed to compare the outcomes of an occupational therapist-led and a nurse-led computerized cognitive training (CCT) for mild cognitive impairment (MCI) in older adults. Design
   A single-blind randomized controlled trial was performed. Methods
   Participants 65 years of age and older with MCI were randomly assigned to a group led by an occupational therapist or by a nurse. Both groups received CCT for 4 weeks. Findings
   Six participants in the occupational therapist-led group and nine in the nurse-led group completed CCT. The nurse-led group showed significant improvement in scores on the Seoul Verbal Learning Test-Elderly's version immediate recall scores (p = .030) and the Korean-Boston Naming Test (p = .012). Conclusions
   Nurse-led CCT demonstrated improvement in some language and memory areas in older adults with MCI.
C1 [Oh, Min Woo; Kim, Si Yeon; Oh, Youngmin; Yoo, Suwon; Cho, Aeri; Lee, Goo Joo] Chungbuk Natl Univ Hosp, Dept Rehabil Med, 776,1 Sunhwan Ro, Cheongju 28644, Chungcheongbuk, South Korea.
   [Oh, Min Woo; Lee, Goo Joo] Chungbuk Natl Univ, Dept Rehabil Med, Coll Med, Cheongju, South Korea.
   [Ki, Young Jin; Jeon, Byoung Hyun] CNC Yullyang Hosp, Cheongju, South Korea.
   [Seo, Joo Han] M3 Solut Co Ltd, Daegu Si, South Korea.
C3 Chungbuk National University; Chungbuk National University Hospital;
   Chungbuk National University
RP Lee, GJ (corresponding author), Chungbuk Natl Univ Hosp, Dept Rehabil Med, 776,1 Sunhwan Ro, Cheongju 28644, Chungcheongbuk, South Korea.
EM omo11017@naver.com; soulover7@hanmail.net; bh-jun@daum.net;
   clear0818@naver.com; avm5126@naver.com; sw1181@naver.com;
   and07@naver.com; joohwan.seo@m3solutions.co.kr; gjlee1225@gmail.com
RI Lee, Goo Joo/AFP-4054-2022
OI Lee, Goo Joo/0000-0002-8436-4463
FU National Research Foundation of Korea - Korea government (MSIT)
   [2017R1E1A1A01074950]; National Research Foundation of Korea
   [2017R1E1A1A01074950] Funding Source: Korea Institute of Science &
   Technology Information (KISTI), National Science & Technology
   Information Service (NTIS)
FX This work was supported by a National Research Foundation of Korea grant
   funded by the Korea government (MSIT; No. 2017R1E1A1A01074950).
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NR 41
TC 4
Z9 4
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0278-4807
EI 2048-7940
J9 REHABIL NURS
JI Rehabil. Nurs.
PD MAY-JUN
PY 2021
VL 46
IS 3
BP 163
EP 171
DI 10.1097/rnj.0000000000000264
PG 9
WC Nursing; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Rehabilitation
GA SD9VG
UT WOS:000651723600006
PM 32304482
DA 2023-08-17
ER

PT J
AU Hampstead, BM
   Stringer, AY
   Iordan, AD
   Ploutz-Snyder, R
   Sathian, K
AF Hampstead, Benjamin M.
   Stringer, Anthony Y.
   Iordan, Alexandru D.
   Ploutz-Snyder, Robert
   Sathian, K.
TI Toward rational use of cognitive training in those with mild cognitive
   impairment
SO ALZHEIMERS & DEMENTIA
LA English
DT Article
DE aging; Alzheimer's disease; cognitive rehabilitation; cognitive
   training; dementia; fMRI; MCI
ID FACE-NAME PAIRS; EFFECTIVE CONNECTIVITY; BRAIN PLASTICITY; MEMORY;
   METAANALYSIS; ACTIVATION; FMRI; REHABILITATION; MODEL
AB The term cognitive training includes a range of techniques that hold potential for treating cognitive impairment caused by neurologic injury and disease. Our central premise is that these techniques differ in their mechanisms of action and therefore engage distinct brain regions (or neural networks). We support this premise using data from a single-blind randomized-controlled trial in which patients with mild cognitive impairment were randomized to either mnemonic strategy training (MST) or spaced retrieval training (SRT) as they learned ecologically relevant object-location associations. Both training approaches were highly effective in the short term, but MST demonstrated a clear advantage after days to weeks. MST also increased activation in and functional connectivity between frontal, temporal, and parietal regions as well as the hippocampus. In contrast, patterns of reduced activation and functional connectivity were evident following SRT. These findings support the rational development of cognitive training techniques.
C1 [Hampstead, Benjamin M.] VA Ann Arbor Healthcare Syst, Mental Hlth Serv, Ann Arbor, MI USA.
   [Hampstead, Benjamin M.; Iordan, Alexandru D.] Univ Michigan, Dept Psychiat, Res Program Cognit & Neuromodulat Based Intervent, Ann Arbor, MI 48109 USA.
   [Hampstead, Benjamin M.; Stringer, Anthony Y.] Emory Univ, Dept Rehabil Med, Atlanta, GA 30322 USA.
   [Stringer, Anthony Y.] Emory Univ, Psychol, Atlanta, GA 30322 USA.
   [Iordan, Alexandru D.] Univ Michigan, Dept Psychol, Ann Arbor, MI USA.
   [Ploutz-Snyder, Robert] Univ Michigan, Syst Populat & Leadership, Ann Arbor, MI 48109 USA.
   [Ploutz-Snyder, Robert] Univ Michigan, Appl Biostat Lab, Ann Arbor, MI 48109 USA.
   [Sathian, K.] Penn State Hlth Milton S Hershey Med Ctr, Dept Neurol, Hershey, PA USA.
   [Sathian, K.] Penn State Univ, Dept Neural & Behav Sci, Hershey, PA USA.
   [Sathian, K.] Penn State Univ, Dept Psychol, Hershey, PA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Ann Arbor Healthcare System; University of Michigan System;
   University of Michigan; Emory University; Emory University; University
   of Michigan System; University of Michigan; University of Michigan
   System; University of Michigan; University of Michigan System;
   University of Michigan; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Penn State Health;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Hampstead, BM (corresponding author), Suite 2400,Bldg 1,4251 Plymouth Rd, Ann Arbor, MI 48105 USA.
EM bhampste@med.umich.edu
RI Ploutz-Snyder, Robert/GSN-2585-2022
OI Hampstead, Benjamin/0000-0003-2717-6375
FU Department of Veterans Affairs, VeteransHealthAdministration, Office of
   Research andDevelopment, and Rehabilitation Research and Development
   Service [IRX001534, B6366W]; Emory Alzheimer's Disease Research Center
   [NIA: P50AG025688]; National Institute on Aging (NIA) [R35AG072262]
FX This work was supported by the Department of Veterans Affairs,
   VeteransHealthAdministration, Office of Research andDevelopment, and
   Rehabilitation Research and Development Service (IRX001534 and B6366W to
   BMH) and by the Emory Alzheimer's Disease Research Center (NIA:
   P50AG025688). Support toBMHfrom the National Institute on Aging (NIA)
   R35AG072262 (effort and analytic infrastructure) is also acknowledged.
   The contents of this manuscript are solely the responsibility of the
   authors and do not represent the views of the National Institutes of
   Health, the Department of Veterans Affairs, or the United States
   Government.
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NR 34
TC 1
Z9 1
U1 7
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-5260
EI 1552-5279
J9 ALZHEIMERS DEMENT
JI Alzheimers. Dement.
PD MAR
PY 2023
VL 19
IS 3
BP 933
EP 945
DI 10.1002/alz.12718
EA JUL 2022
PG 13
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA C3LN8
UT WOS:000820961400001
PM 35791724
OA hybrid
DA 2023-08-17
ER

PT J
AU Laiz, NM
   Diaz, SD
   Collado, NR
   Gomez-Pilar, J
   Hornero, R
AF Mendoza Laiz, Nuria
   Del Valle Diaz, Sagrario
   Rioja Collado, Natalia
   Gomez-Pilar, Javier
   Hornero, Roberto
TI Potential benefits of a cognitive training program in mild cognitive
   impairment (MCI)
SO RESTORATIVE NEUROLOGY AND NEUROSCIENCE
LA English
DT Article
DE MCI; BCI; Neuro-feedback; Luria-DNA; independence ageing; autonomy
   ageing
ID OLDER-ADULTS; INTERVENTIONS; EFFICACY; PEOPLE
AB Background: Dementia is a disease that is constantly evolving in older people. Its diverse symptoms appear with varying degrees of severity affecting the daily life of those who suffer from it. The rate in which dementia progresses depends on different aspects of the treatment, chosen to try to control and slow down the development of the illness.
   Objective: The aim of this study is to assess the effectiveness of cognitive training through a Brain Computer Interface (BCI) and the NeuronUp platform in two age groups whose MMSE is between 18-23 MCI (mild dementia).
   Method: 32 subjects took part in the study. There were 22 subjects in Group 1 (61-69 years of age) and 10 subjects in Group 2 (70-81 years of age). The criterium for the selection of the groups was to identify the age range with greater improvements due to the training. In order to estimate neuropsychological performance, the subjects were evaluated with the Luria-DNA neuropsychological battery before and after training. This design enables us to evaluate five cognitive areas: visuospatial, spoken language, memory, intellectual processes and attention.
   Results: After training, Group 1 showed significant improvements in almost all the variables measured when compared with Group 2. This reveals a significant increase in cognitive ability, the degree of which depends on the age.
   Conclusion: People with mild dementia may delay cognitive impairment with a suitable cognitive training program.
C1 [Mendoza Laiz, Nuria; Del Valle Diaz, Sagrario; Rioja Collado, Natalia] UCLM, Dept Phys Act & Sport Sci, Toledo, Spain.
   [Gomez-Pilar, Javier; Hornero, Roberto] Univ Valladolid, Biomed Engn Grp, Valladolid, Spain.
C3 Universidad de Castilla-La Mancha; Universidad de Valladolid
RP Diaz, SD (corresponding author), UCLM, Avda Carlos III S-N, Toledo 45571, Spain.
EM sagrariodel.valle@uclm.es
RI Hornero, Roberto/M-5313-2019; Gomez-Pilar, Javier/B-9123-2018
OI Hornero, Roberto/0000-0001-9915-2570; Gomez-Pilar,
   Javier/0000-0001-7882-7890
FU Ministerio de Economia y Competitividad [TEC2014-53196-R]; FEDER
   [TEC2014-53196-R]; European Commission [POCTEP 0378_AD_EEGWA_2_P];
   Consejeria de Educacion de la Junta de Castilla y Leon [VA037U16];
   University of Valladolid
FX This research project was supported in part by "Ministerio de Economia y
   Competitividad" and FEDER under project TEC2014-53196-R, by 'European
   Commission' (POCTEP 0378_AD_EEGWA_2_P), and by 'Consejeria de Educacion
   de la Junta de Castilla y Leon' (VA037U16). J. Gomez-Pilar was in
   receipt of a grant from University of Valladolid.
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NR 30
TC 14
Z9 14
U1 1
U2 18
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 0922-6028
EI 1878-3627
J9 RESTOR NEUROL NEUROS
JI Restor. Neurol. Neurosci.
PY 2018
VL 36
IS 2
BP 207
EP 213
DI 10.3233/RNN-170754
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FY7GK
UT WOS:000427029600006
PM 29526855
DA 2023-08-17
ER

PT J
AU Rosen, AC
   Sugiura, L
   Kramer, JH
   Whitfield-Gabrieli, S
   Gabrieli, JD
AF Rosen, Allyson C.
   Sugiura, Lisa
   Kramer, Joel H.
   Whitfield-Gabrieli, Susan
   Gabrieli, John D.
TI Cognitive Training Changes Hippocampal Function in Mild Cognitive
   Impairment: A Pilot Study
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE MRI; dementia; cognition; MCI; mild cognitive impairment; fMRI;
   functional MRI; cognitive training; hippocampus; medial temporal lobe
ID MEDIAL TEMPORAL-LOBE; ALZHEIMERS-DISEASE; MEMORY PERFORMANCE; BRAIN
   PLASTICITY; LEISURE ACTIVITIES; ELDERLY SUBJECTS; FRONTAL-CORTEX;
   OLDER-ADULTS; LIFE-STYLE; FMRI
AB A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.
C1 [Rosen, Allyson C.; Sugiura, Lisa] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA.
   [Rosen, Allyson C.] Palo Alto Vet Affairs Hlth Care Syst, Palo Alto, CA USA.
   [Rosen, Allyson C.; Sugiura, Lisa; Whitfield-Gabrieli, Susan; Gabrieli, John D.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
   [Kramer, Joel H.] UCSF Med Ctr, Memory & Aging Ctr, San Francisco, CA USA.
   [Whitfield-Gabrieli, Susan; Gabrieli, John D.] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.
C3 Stanford University; Stanford University; University of California
   System; University of California San Francisco; UCSF Medical Center;
   Massachusetts Institute of Technology (MIT)
RP Rosen, AC (corresponding author), Palo Alto VA Med Ctr, 3801 Miranda Ave,151Y, Palo Alto, CA 94304 USA.
EM rosena@psych.stanford.edu
RI Gabrieli, John/AAJ-2869-2020
FU NIA [K01AG025157, AG12995, AG09466, AG05865 01]; NIMH [MH35182,
   MH59940]; NCRR [RR09784]; Posit Science Corporation
FX Grant Support: NIA (K01AG025157, AG12995, AG09466, AG05865 01), NIMH
   (MH35182, MH59940), NCRR (RR09784) and Posit Science. Thanks to Natalia
   Belfor.; This study received funding from Posit Science Corporation
   through research grants to Stanford University and the University of
   California, San Francisco. Posit Science Corporation is the developer of
   the experimental training program and holds patents for and a
   proprietary interest in this software. No authors hold stock or stock
   options in Posit Science Corporation or were directly compensated by
   Posit Science Corporation. Ultimate responsibility for the design and
   conduct of the brain imaging portion of the trial and the analysis of
   the data resided with the principal investigators, Drs. A. Rosen and J.
   Gabrieli, who had complete and unrestricted access to the dataset.
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NR 45
TC 104
Z9 112
U1 2
U2 47
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2011
VL 26
SU 3
BP 349
EP 357
DI 10.3233/JAD-2011-0009
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 858ZM
UT WOS:000297842800027
PM 21971474
OA Green Accepted, Green Submitted, Green Published
DA 2023-08-17
ER

PT J
AU Tian, R
   Jiang, YJ
   Zhang, YC
   Yan, XY
   Zhou, YW
   Chen, DQ
AF Tian, Rui
   Jiang, Yujuan
   Zhang, Yanchun
   Yan, Xinyue
   Zhou, Yingwen
   Chen, Deqiang
TI Cognitive training program improves cognitive ability and daily living
   ability in elderly patients with mild cognitive impairment
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Cognitive training program; Mild cognitive impairment; Cognitive
   function; S100 beta; NSE
ID NEURON-SPECIFIC ENOLASE; OLDER-ADULTS; ALZHEIMERS-DISEASE; DEMENTIA;
   DECLINE; S100B
AB Background Mild cognitive impairment (MCI) is a clinical syndrome of mild memory or other cognitive impairment without dementia and is a clinical transition state between normal aging and dementia. Careful and meticulous nursing intervention can improve the clinical symptoms of MCI and delay the progression of the disease.
   Aims This research aimed to evaluate the efficacy of cognitive function training interventions in elderly patients with MCI.
   Methods 106 patients were randomized into the intervention group or the control group. They received conventional nursing intervention and those in the intervention group received additional cognitive training program for 6 weeks. The Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), activities of daily living (ADL) scales, and Barthel index (BI) were evaluated before and 6 weeks after the intervention, as well as the serum levels of S100 beta and neuron-specific enolase (NSE) at two time points.
   Results After intervention, the MMSE scores and MoCA scores in both groups were significantly increased and the score in the intervention group was significantly higher. In the intervention group, the performance of conventional nursing intervention and cognitive training program significantly increased the scores of ADL and BI (p < 0.001). The serum levels of NSE and S100 beta in the intervention group were significantly lower.
   Discussion The performance of cognitive training program alleviated the brain tissue damage in elderly patients with MCI.
   Conclusions The performance of cognitive training program in elderly patients with MCI improved their cognitive ability and daily living ability.
C1 [Tian, Rui; Jiang, Yujuan; Zhang, Yanchun; Yan, Xinyue] Cangzhou Cent Hosp, Dept Rehabil, Cangzhou 061000, Hebei, Peoples R China.
   [Zhou, Yingwen] Cangzhou Cent Hosp, Dept Magnet Resonance, Cangzhou 061000, Hebei, Peoples R China.
   [Chen, Deqiang] Cangzhou Cent Hosp, Dept Comp Tomog, Cangzhou 061000, Hebei, Peoples R China.
RP Tian, R (corresponding author), Cangzhou Cent Hosp, Dept Rehabil, Cangzhou 061000, Hebei, Peoples R China.
EM qingmei_2002@163.com
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NR 35
TC 2
Z9 3
U1 10
U2 21
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD MAY
PY 2022
VL 34
IS 5
SI SI
BP 997
EP 1005
DI 10.1007/s40520-021-02015-6
EA NOV 2021
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 1U7OF
UT WOS:000717918700001
PM 34767246
DA 2023-08-17
ER

PT J
AU Vermeij, A
   Kessels, RPC
   Heskamp, L
   Simons, EMF
   Dautzenberg, PLJ
   Claassen, JAHR
AF Vermeij, Anouk
   Kessels, Roy P. C.
   Heskamp, Linda
   Simons, Esther M. F.
   Dautzenberg, Paul L. J.
   Claassen, Jurgen A. H. R.
TI Prefrontal activation may predict working-memory training gain in normal
   aging and mild cognitive impairment
SO BRAIN IMAGING AND BEHAVIOR
LA English
DT Article
DE Alzheimer's disease; Cognitive training; Neuroimaging; Optical imaging;
   Plasticity; Working memory
ID NEAR-INFRARED SPECTROSCOPY; CEREBRAL BLOOD-VOLUME; MINI-MENTAL-STATE;
   OLDER-ADULTS; BRAIN ACTIVATION; AGE-DIFFERENCES; PLASTICITY;
   PERFORMANCE; MAINTENANCE; TASK
AB Cognitive training has been shown to result in improved behavioral performance in normal aging and mild cognitive impairment (MCI), yet little is known about the neural correlates of cognitive plasticity, or about individual differences in responsiveness to cognitive training. In this study, 21 healthy older adults and 14 patients with MCI received five weeks of adaptive computerized working-memory (WM) training. Before and after training, functional Near-Infrared Spectroscopy (fNIRS) was used to assess the hemodynamic response in left and right prefrontal cortex during performance of a verbal n-back task with varying levels of WM load. After training, healthy older adults demonstrated decreased prefrontal activation at high WM load, which may indicate increased processing efficiency. Although MCI patients showed improved behavioral performance at low WM load after training, no evidence was found for training-related changes in prefrontal activation. Whole-group analyses showed that a relatively strong hemodynamic response at low WM load was related to worse behavioral performance, while a relatively strong hemodynamic response at high WM load was related to higher training gain. Therefore, a 'youth-like' prefrontal activation pattern at older age may be associated with better behavioral outcome and cognitive plasticity.
C1 [Vermeij, Anouk; Kessels, Roy P. C.; Claassen, Jurgen A. H. R.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
   [Vermeij, Anouk; Heskamp, Linda; Simons, Esther M. F.; Claassen, Jurgen A. H. R.] Radboud Univ Nijmegen, Dept Geriatr Med, Med Ctr, Route 925,POB 9101, NL-6500 HB Nijmegen, Netherlands.
   [Kessels, Roy P. C.] Radboud Univ Nijmegen, Dept Med Psychol, Med Ctr, Nijmegen, Netherlands.
   [Dautzenberg, Paul L. J.] Jeroen Bosch Hosp, Dept Geriatr Med, Shertogenbosch, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Radboud
   University Nijmegen; Jeroen Bosch Ziekenhuis
RP Claassen, JAHR (corresponding author), Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.; Claassen, JAHR (corresponding author), Radboud Univ Nijmegen, Dept Geriatr Med, Med Ctr, Route 925,POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM Jurgen.Claassen@radboudumc.nl
RI Vermeij, Anouk/J-5934-2012; Heskamp, Linda/P-4762-2018; Kessels, Roy
   P.C./D-1902-2010; Claassen, Jurgen A.H.R./A-9806-2008
OI Heskamp, Linda/0000-0002-6828-9336; Kessels, Roy
   P.C./0000-0001-9500-9793; Claassen, Jurgen A.H.R./0000-0002-1778-8151
FU Donders TopTalent Grant - Netherlands Organisation for Scientific
   Research (NWO) [022-001-026]; Alzheimer Nederland [WE03-2010-03]
FX This project was funded by a Donders TopTalent Grant supported by The
   Netherlands Organisation for Scientific Research (NWO) (no. 022-001-026)
   awarded to AV, and a grant from Alzheimer Nederland (no. WE03-2010-03)
   awarded to JC. The authors would like to thank Maurice Rijnaard, Karima
   Helweh-Abidi and Laura Versteeg for their help in recruiting and
   coaching the participants.
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NR 70
TC 74
Z9 79
U1 2
U2 35
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1931-7557
EI 1931-7565
J9 BRAIN IMAGING BEHAV
JI Brain Imaging Behav.
PD FEB
PY 2017
VL 11
IS 1
BP 141
EP 154
DI 10.1007/s11682-016-9508-7
PG 14
WC Neuroimaging
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA ET8TT
UT WOS:000400575300012
PM 26843001
OA hybrid, Green Published
DA 2023-08-17
ER

PT J
AU Peng, ZR
   Jiang, H
   Wang, XM
   Huang, KY
   Zuo, YK
   Wu, XM
   Abdullah, A
   Yang, L
AF Peng, Zhenren
   Jiang, Hu
   Wang, Xiaomin
   Huang, Kaiyong
   Zuo, Yukun
   Wu, Xiangmin
   Abdullah, Abu S.
   Yang, Li
TI The Efficacy of Cognitive Training for Elderly Chinese Individuals with
   Mild Cognitive Impairment
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; ASSESSMENT MOCA; CLINICAL-TRIAL;
   DEMENTIA; RISK; PREVALENCE; COMMUNITY; INTERVENTIONS; POPULATION
AB The age of the population is shifting toward the elderly range, which may lead to an increased risk of mild cognitive impairment (MCI). The aims of this study are to evaluate the cognitive function in elderly people using the Montreal Cognitive Assessment (MoCA), to identify the relationship between cognitive function and different characteristics, and to evaluate the efficacy of the intervention after six months of cognitive training. In this study, we included 2886 subjects aged >= 60 years in the baseline survey, and 140 subjects with MCI who participated in the baseline survey were randomly divided into an intervention group (N = 70) and a control group (N = 70). The control group was not provided any intervention measures, and the intervention group was administered cognitive training. The education level, monthly income, sleep time, exercise time, reading times, and time spent engaging in community activities and performing housework were positively correlated with MoCA scores, but age was negatively correlated with MoCA scores. The total MoCA score of the intervention group increased from 19.77 +/- 2.24 points to 21.09 +/- 2.20 points after six months of cognitive training, but the score of the control group decreased from 20.41 +/- 2.10 points to 19.17 +/- 2.57 points. The two-way repeated-measures ANOVA revealed a very significant effect of the interaction between time and cognitive training on the total MoCA score. Seventeen participants in the intervention group improved to normal levels, and no participants progressed to dementia after six months of cognitive training. Thus, the efficacy of the intervention was statistically significant. Our study concludes that older age is associated with a cognitive decline. Factors that are more likely to protect against cognitive decline included a higher education level and monthly income, sufficient sleep time, regular physical exercise and reading, frequently engaging in community activities, and continuing to perform housework. Moreover, the cognitive training intervention is effective and may help to decrease the deterioration of cognitive function in patients with MCI, and the interaction between intervention time and cognitive training significantly improves cognitive function.
C1 [Peng, Zhenren; Jiang, Hu; Huang, Kaiyong; Zuo, Yukun; Wu, Xiangmin; Yang, Li] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Nanning 530021, Peoples R China.
   [Wang, Xiaomin] Guangxi Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Nanning 530021, Peoples R China.
   [Abdullah, Abu S.] Duke Kunshan Univ, Global Hlth Res Ctr, Kunshan 215316, Peoples R China.
   [Abdullah, Abu S.] Boston Univ, Sch Med, Boston Med Ctr, Boston, MA 02118 USA.
C3 Guangxi Medical University; Guangxi Medical University; Duke Kunshan
   University; Boston Medical Center; Boston University
RP Yang, L (corresponding author), Guangxi Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Nanning 530021, Peoples R China.
EM yangli8290@hotmail.com
OI Abdullah, Abu/0000-0002-9841-0344; Peng, Zhenren/0000-0003-3163-5386;
   Huang, Kai Yong/0000-0001-8206-7513
FU Scientific and Technological Tackling Plan of Scientific Research and
   Technological Development Projects in Guangxi [1598012-14]; Innovation
   Project of Guangxi Graduate Education [YCBZ2019034]; Nature Science
   Foundation of Guangxi [2016GXNSFBA380023]
FX This research was funded by the Scientific and Technological Tackling
   Plan of Scientific Research and Technological Development Projects in
   Guangxi (Grant no. 1598012-14), the Innovation Project of Guangxi
   Graduate Education (Grant no. YCBZ2019034), and the Nature Science
   Foundation of Guangxi (Grant no. 2016GXNSFBA380023).
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NR 51
TC 19
Z9 20
U1 1
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD NOV 30
PY 2019
VL 2019
AR 4347281
DI 10.1155/2019/4347281
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA JU6DQ
UT WOS:000501765600004
PM 31886216
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Belleville, S
   Hudon, C
   Bier, N
   Brodeur, C
   Gilbert, B
   Grenier, S
   Ouellet, MC
   Viscogliosi, C
   Gauthier, S
AF Belleville, Sylvie
   Hudon, Carol
   Bier, Nathalie
   Brodeur, Catherine
   Gilbert, Brigitte
   Grenier, Sebastien
   Ouellet, Marie-Christine
   Viscogliosi, Chantal
   Gauthier, Serge
TI MEMO plus : Efficacy, Durability and Effect of Cognitive Training and
   Psychosocial Intervention in Individuals with Mild Cognitive Impairment
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE cognitive training; mild cognitive impairment; cognition; psychosocial
   intervention
ID HEALTHY OLDER-ADULTS; ALZHEIMERS-DISEASE; PSYCHOMETRIC PROPERTIES;
   ATTENTIONAL CONTROL; CONTROLLED-TRIAL; DEPRESSION; VALIDATION; DEMENTIA;
   IMPACT; REHABILITATION
AB Background/ObjectivesThere is no consensus on the efficacy of cognitive training in persons with mild cognitive impairment (MCI) because of the paucity of well-designed randomized controlled trials. The objective was to assess the effect of memory training on the cognitive functioning of persons with MCI and its durability and to evaluate whether this effect generalizes to daily life and whether positive effects could be obtained from psychosocial intervention.
   DesignSingle-blind randomized controlled trial.
   SettingResearch centers of the Institut Universitaire de Geriatrie de Montreal and Institut Universitaire en Sante Mentale de Quebec.
   ParticipantsOlder adults meeting criteria for amnestic MCI (N=145).
   InterventionParticipants were randomized to cognitive training, a psychosocial intervention, or a no-contact control condition. Interventions were provided in small groups in eight 2-hour sessions.
   MeasurementOutcome measures were immediate and delayed composite performance memory scores, psychological health (depression, anxiety, well-being), and generalization effects of the intervention (strategy use in everyday life, difficulties in complex activities of daily living, memory complaints). Testing was administered before training and immediately, 3months, and 6months after training.
   ResultsParticipants in the cognitive training condition improved on the delayed composite memory score and on strategy use in everyday life. Improvement was maintained at the 3- and 6-month follow-up assessments. Participants in the psychosocial and no-contact conditions did not show any significant improvement.
   ConclusionCognitive training improves the memory of persons with amnestic MCI. The effect persists over a 6-month period, and learned strategies are used in everyday life. Cognitive training is a valid way to promote cognition in MCI.
   See related editorial by .
C1 [Belleville, Sylvie; Bier, Nathalie; Brodeur, Catherine; Gilbert, Brigitte; Grenier, Sebastien] Inst Univ Geriatrie Montreal, Montreal, PQ, Canada.
   [Belleville, Sylvie; Bier, Nathalie; Brodeur, Catherine; Gilbert, Brigitte; Grenier, Sebastien] Univ Montreal, Montreal, PQ, Canada.
   [Hudon, Carol] CERVO Res Ctr, Quebec City, PQ, Canada.
   [Hudon, Carol; Ouellet, Marie-Christine] Univ Laval, Quebec City, PQ, Canada.
   [Ouellet, Marie-Christine] Ctr Interdisciplinaire Rech Readaptat & Integrat, Quebec City, PQ, Canada.
   [Viscogliosi, Chantal] Res Ctr Aging CIUSSS Estrie CHUS, Sherbrooke, PQ, Canada.
   [Viscogliosi, Chantal] Univ Sherbrooke, Sherbrooke, PQ, Canada.
   [Gauthier, Serge] McGill Univ, Ctr Studies Aging, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; Laval University;
   University of Sherbrooke; McGill University
RP Belleville, S (corresponding author), Inst Univ Geriatrie Montreal, Ctr Rech, 4565 Queen Mary, Montreal, PQ H3W 1W5, Canada.
EM sylvie.belleville@umontreal.ca
RI Grenier, Sébastien/AAA-4573-2021
OI Hudon, Carol/0000-0002-7554-3187; Ouellet,
   Marie-Christine/0000-0003-3477-1893; Brodeur,
   Catherine/0000-0001-9885-9478
FU Canadian Institutes for Health Research [MOP115086]; Fonds de recherche
   du Quebec-Sante
FX This work was supported by a grant from the Canadian Institutes for
   Health Research (MOP115086). CH, MCO, SGre, and NB were supported by
   salary awards from the Fonds de recherche du Quebec-Sante. The sponsors
   were not involved in the design, methods, recruitment, data collection,
   analysis or preparation of the paper.
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NR 49
TC 49
Z9 55
U1 2
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD APR
PY 2018
VL 66
IS 4
BP 655
EP 663
DI 10.1111/jgs.15192
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GD1ZW
UT WOS:000430300800005
PM 29313875
OA hybrid
DA 2023-08-17
ER

PT J
AU Heo, S
   Park, JH
AF Heo, Seoyoon
   Park, Jin-Hyuck
TI Cognition-Specific Computerized Cognitive Training in Older Adults with
   Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Review
DE mild cognitive impairment; computerized cognitive training; cognition;
   meta-analysis
ID ALZHEIMERS-DISEASE; INTERVENTIONS; DEMENTIA; EFFICACY; OUTCOMES; RISK
AB To date, previous meta-analyses reported that computerized cognitive training (CCT) was a clinically beneficial intervention for cognitive function in older adults with mild cognitive impairment (MCI). However, little is known about the efficacy of narrowly defined cognition-specific CCT excluding commercial video games on cognitive function in patients with MCI. Randomized controlled trials (RCTs) of CCT in older adults with MCI were searched through CINAHL, Embase, Medline, PubMed, and PsychINFO. The overall cognitive domains, global cognitive function, attention, memory, working memory, and executive function were pooled separately for MCI. The overall effect on cognitive function in MCI across 8 trials was moderate (Hedges' g = 0.48, 95% confidence interval (CI) = 0.003-0.974). There was no significant publication bias. Moderate to large effects were found for global cognitive function, memory, and working memory, with the exception of attention, and executive function. Cognition-specific CCT was beneficial in improving global cognitive function, memory, and working memory in older adults with MCI. Therefore, this intervention warrants long-term trials with a larger number of subjects to investigate the effect on conversion from MCI to dementia. Copyright (C) 2021, Taiwan Society of Geriatric Emergency & Critical Care Medicine.
C1 [Heo, Seoyoon] Kyungbok Univ, Dept Occupat Therapy, Namyangju, South Korea.
   [Park, Jin-Hyuck] Soonchunhyang Univ, Coll Med Sci, Dept Occupat Therapy, Asan, South Korea.
C3 Soonchunhyang University
RP Park, JH (corresponding author), Coll Med Sci, Room 1401,22 Soonchunhyang Ro, Asan 31538, Chungcheongnam, South Korea.
EM roophy@naver.com
RI Heo, Seoyoon/ACL-4933-2022
OI Heo, Seoyoon/0000-0003-0763-8245; Park, Jin-Hyuck/0000-0002-0222-8901
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [2019R1F1A1060719]; Soonchunhyang University Research Fund; National
   Research Foundation of Korea [2019R1F1A1060719] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIT) (No.
   2019R1F1A1060719).; This work was supported by the Soonchunhyang
   University Research Fund.
CR [Anonymous], 2017, COGNITIVE NEUROSCIEN
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NR 32
TC 0
Z9 0
U1 3
U2 28
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD APR
PY 2021
VL 15
IS 2
BP 90
EP 96
DI 10.6890/IJGE.202104_15(2).0001
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA RP4FE
UT WOS:000641684600002
DA 2023-08-17
ER

PT J
AU Biundo, R
   Weis, L
   Fiorenzato, E
   Gentile, G
   Giglio, M
   Campo, M
   Schifano, R
   Antonini, A
AF Biundo, R.
   Weis, L.
   Fiorenzato, E.
   Gentile, G.
   Giglio, M.
   Campo, M.
   Schifano, R.
   Antonini, A.
TI Brain connectivity changes associated with t-DCS and cognitive training
   plus cognitive training in Parkinson's disease with mild cognitive
   impairment
SO MOVEMENT DISORDERS
LA English
DT Meeting Abstract
CT 19th International Congress of Parkinson's Disease and Movement
   Disorders
CY JUN 14-18, 2015
CL San Diego, CA
SP Int Parkinson Movement Disorders Soc
RI Antonini, Angelo/H-9726-2019; Weis, Luca/J-2805-2018; Fiorenzato,
   Eleonora/ABF-5939-2021
OI Antonini, Angelo/0000-0003-1040-2807; Weis, Luca/0000-0002-2286-0795;
   Fiorenzato, Eleonora/0000-0001-7947-5903
NR 0
TC 0
Z9 0
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-3185
EI 1531-8257
J9 MOVEMENT DISORD
JI Mov. Disord.
PD JUN
PY 2015
VL 30
SU 1
MA 972
BP S376
EP S377
PG 2
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology
GA CK9ZN
UT WOS:000356598201316
DA 2023-08-17
ER

PT J
AU Bernini, S
   Alloni, A
   Panzarasa, S
   Picascia, M
   Quaglini, S
   Tassorelli, C
   Sinforiani, E
AF Bernini, Sara
   Alloni, Anna
   Panzarasa, Silvia
   Picascia, Marta
   Quaglini, Silvana
   Tassorelli, Cristina
   Sinforiani, Elena
TI A computer-based cognitive training in Mild Cognitive Impairment in
   Parkinson's Disease
SO NEUROREHABILITATION
LA English
DT Article
DE Cognitive training; executive dysfunctions; Parkinson's Disease;
   randomized controlled trial
ID NORMATIVE VALUES; OLDER-PEOPLE; EFFICACY; STIMULATION; PREDICTORS;
   BATTERY; PROGRAM; DECLINE; SCORE; MOCA
AB BACKGROUND: There is no successful pharmacological treatment for cognitive impairment in Parkinson's Disease, therefore treatments capable of slowing down the progression of cognitive dysfunction are needed.
   OBJECTIVE: To evaluate the effectiveness of a cognitive training, supported by the CoRe computerized tool, in patients with Parkinson's Disease Mild Cognitive Impairment.
   METHODS: This is a prospective, open-unblinded, randomized, controlled study. After baseline cognitive assessment (T0), enrolled patients were randomized to receive motor rehabilitation plus cognitive intervention (G1) or motor rehabilitation only (G2). Follow-up assessments were scheduled 4 weeks (T1) and 6 months after (T2). Global cognitive functioning scores (MOCA and MMSE) were considered as primary outcome. Outcome measures at T0, T1 and T2 were compared within-and between-groups. A percentage change score between TO and next assessments was calculated to identify patients who improved, remain stable or worsened.
   RESULTS: Differently from G2, G1 showed a medium/large effect size improvement in primary (MoCA) and secondary outcome, both between T0 and T1 and T0 and T2. Moreover, within G1, most patients improved their cognitive state compared to the baseline.
   CONCLUSIONS: Patients trained with CoRe showed a better evolution of cognitive decline, while untreated patients tended to get worse over time.
C1 [Bernini, Sara; Picascia, Marta; Sinforiani, Elena] IRCCS Mondino Fdn, Neuropsychol Alzheimers Dis Assessment Unit, Via Mondino 2, I-27100 Pavia, Italy.
   [Alloni, Anna; Panzarasa, Silvia; Quaglini, Silvana] Univ Pavia, Dept Elect Comp & Biomed Engn, Pavia, Italy.
   [Tassorelli, Cristina] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy.
   [Tassorelli, Cristina] IRCCS Mondino Fdn, Neurorehabil Unit, Pavia, Italy.
C3 IRCCS Fondazione Casimiro Mondino; University of Pavia; University of
   Pavia; IRCCS Fondazione Casimiro Mondino
RP Bernini, S (corresponding author), IRCCS Mondino Fdn, Neuropsychol Alzheimers Dis Assessment Unit, Via Mondino 2, I-27100 Pavia, Italy.
EM sara.bernini@mondino.it
RI quaglini, silvana/AAC-2687-2022; Bernini, Sara/K-5971-2016; Sinforiani,
   Elena/AAB-6052-2020; Tassorelli, Cristina/AAC-1483-2019
OI quaglini, silvana/0000-0002-4288-2561; Bernini,
   Sara/0000-0001-8615-0242; Tassorelli, Cristina/0000-0003-1513-2113
FU Italian Ministry of Health
FX This work was supported by grants of the Italian Ministry of Health to
   2017.
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NR 41
TC 19
Z9 22
U1 1
U2 7
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1053-8135
EI 1878-6448
J9 NEUROREHABILITATION
JI Neurorehabilitation
PY 2019
VL 44
IS 4
BP 555
EP 567
DI 10.3233/NRE-192714
PG 13
WC Clinical Neurology; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Rehabilitation
GA IK4NR
UT WOS:000476564100009
PM 31256092
DA 2023-08-17
ER

PT J
AU Zhang, HF
   Huntley, J
   Bhome, R
   Holmes, B
   Cahill, J
   Gould, RL
   Wang, HL
   Yu, X
   Howard, R
AF Zhang, Haifeng
   Huntley, Jonathan
   Bhome, Rohan
   Holmes, Benjamin
   Cahill, Jack
   Gould, Rebecca L.
   Wang, Huali
   Yu, Xin
   Howard, Robert
TI Effect of computerised cognitive training on cognitive outcomes in mild
   cognitive impairment: a systematic review and meta-analysis
SO BMJ OPEN
LA English
DT Article
DE mild cognitive training (MCI); computerised; cognitive training;
   cognitive outcomes; meta-analysis
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; RISK; REHABILITATION; INTERVENTIONS;
   EFFICACY; PROGRAM; INDIVIDUALS; STIMULATION; HEALTHY
AB Objectives To determine the effect of computerised cognitive training (CCT) on improving cognitive function for older adults with mild cognitive impairment (MCI).
   Design Systematic review and meta-analysis.
   Data sources PubMed, Embase, Web of Science and the Cochrane Library were searched through January 2018.
   Eligibility criteria Randomised controlled trials comparing CCT with control conditions in those with MCI aged 55+ were included.
   Data extraction and synthesis Two independent reviewers extracted data and assessed the risk of bias. Effect sizes (Hedges' g and 95% CIs) were calculated and random-effects meta-analyses were performed where three or more studies investigated a comparable intervention and outcome. Heterogeneity was quantified using the I-2 statistic.
   Results 18 studies met the inclusion criteria and were included in the analyses, involving 690 participants. Meta-analysis revealed small to moderate positive treatment effects compared with control interventions in four domains as follows: global cognitive function (g=0.23, 95%CI 0.03 to 0.44), memory (g=0.30, 95%CI 0.11 to 0.50), working memory (g=0.39, 95%CI 0.12 to 0.66) and executive function (g=0.20, 95%CI -0.03 to 0.43). Statistical significance was reached in all domains apart from executive function.
   Conclusions This meta-analysis provides evidence that CCT improves cognitive function in older people with MCI. However, the long-term transfer of these improvements and the potential to reduce dementia prevalence remains unknown. Various methodological issues such as heterogeneity in outcome measures, interventions and MCI symptoms and lack of intention-to-treat analyses limit the quality of the literature and represent areas for future research.
C1 [Zhang, Haifeng; Huntley, Jonathan; Bhome, Rohan; Holmes, Benjamin; Gould, Rebecca L.; Howard, Robert] UCL, Div Psychiat, London, England.
   [Zhang, Haifeng; Wang, Huali; Yu, Xin] Peking Univ, NHC Key Lab Mental Hlth, Natl Clin Res Ctr Mental Disorders, Inst Mental Hlth,Hosp 6,Beijing Dementia Key Lab, Beijing, Peoples R China.
   [Cahill, Jack] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
C3 University of London; University College London; Peking University;
   University of London; King's College London
RP Huntley, J (corresponding author), UCL, Div Psychiat, London, England.
EM j.huntley@ucl.ac.uk
RI Howard, Robert/E-4890-2010
OI Huntley, Jonathan/0000-0001-6304-6231; Howard,
   Robert/0000-0002-3071-2338
FU Beijing Municipal Science and Technology Commission [Z161100000516001,
   D171100008217007]; China Scholarship Council (CSC) [201706010329]; NIHR
   Academic Clinical Fellowship; NIHR UCLH BRC
FX We acknowledge the funding provided by Beijing Municipal Science and
   Technology Commission (no Z161100000516001, D171100008217007). HZ is
   supported by the China Scholarship Council (CSC) (no 201706010329) to be
   a visiting PhD student at University College London, UK. RB is supported
   by an NIHR Academic Clinical Fellowship. JH, RLG and RH are supported by
   the NIHR UCLH BRC.
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NR 71
TC 63
Z9 68
U1 2
U2 20
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD AUG
PY 2019
VL 9
IS 8
AR e027062
DI 10.1136/bmjopen-2018-027062
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA JV7JK
UT WOS:000502537200093
PM 31427316
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Sukontapol, C
   Kemsen, S
   Chansirikarn, S
   Nakawiro, D
   Kuha, O
   Taemeeyapradit, U
AF Sukontapol, Chalermpong
   Kemsen, Sasithorn
   Chansirikarn, Sirintorn
   Nakawiro, Daochompu
   Kuha, Orawan
   Taemeeyapradit, Unchulee
TI The effectiveness of a cognitive training program in people with mild
   cognitive impairment: A study in urban community
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Cognitive training program; Mild cognitive impairment; Community mental
   health
ID INTERVENTION; STIMULATION; RISK; MCI; AGE
AB Objective: To assess the effectiveness of a cognitive training program on global cognition among people with mild cognitive impairment.
   Methods: In this experimental study, using purposive sampling, 60 participants age 50 years and over who complained of subjective memory impairment were screened in their communities by public health volunteers with the Abbreviated Mental Test. Those with dementia were excluded as well as those with depression, which were screened out by the Thai Geriatric Depression Scale (TGDS-15). Mild cognitive impairment was diagnosed and confirmed by the Montreal Cognitive Assessment (MoCA) and joint agreement between a psychiatrist and a neurologist. The participants were alternately assigned to receive a cognitive training program (intervention group) while the other half received their normal usual therapy (control group). The program involved training of 4 aspects of cognition through 6 sessions; 2 sessions per month for 3 months. The MoCA and TGDS-15 scales were given at baseline and again at week 13, and at months 6 and 9.
   Independent t-tests were used to compare changes in global cognition among the two groups.
   Results: MoCA scores at 9 months were significantly higher than at baseline in both groups. However, the mean difference in intervention group was significantly higher than control group. TGDS-15 scores at 6 months was significantly lower than at baseline among the intervention group but not the control group.
   Conclusion: This cognitive training program helped to improve global cognition and reduce depressive symptoms.
C1 [Sukontapol, Chalermpong] Vachira Phuket Hosp, Community Mental Hlth Care Leadership, Thai Board Community Mental Hlth, Expert Level, Phuket 83000, Thailand.
   [Kemsen, Sasithorn; Taemeeyapradit, Unchulee] Songkhlarajanakarindra Psychiat Hosp, Geriatr Psychiat Clin, Muang Dist 90000, Songkhla, Thailand.
   [Chansirikarn, Sirintorn] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Med, Bangkok 10400, Thailand.
   [Nakawiro, Daochompu] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Psychiat, Bangkok 10400, Thailand.
   [Kuha, Orawan] Minist Publ Hlth, Dept Med Serv, Inst Geriatr Med, Muang Dist 11000, Nonthaburi, Thailand.
C3 Mahidol University; Mahidol University
RP Taemeeyapradit, U (corresponding author), Songkhlarajanakarindra Psychiat Hosp, Geriatr Psychiat Clin, Muang Dist 90000, Songkhla, Thailand.
EM chalermpongs@hotmail.com; sasit3124@hotmail.co.th; rascs@mahidol.ac.th;
   pinkstar1973@gmail.com; orawan_pook@yahoo.com; unchulee44@gmail.com
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NR 38
TC 5
Z9 5
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2018
VL 35
BP 18
EP 23
DI 10.1016/j.ajp.2018.04.028
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA GK7PB
UT WOS:000436398300009
PM 29723721
DA 2023-08-17
ER

PT J
AU Savulich, G
   Piercy, T
   Fox, C
   Suckling, J
   Rowe, JB
   O'Brien, JT
   Sahakian, BJ
AF Savulich, George
   Piercy, Thomas
   Fox, Chris
   Suckling, John
   Rowe, James B.
   O'Brien, John T.
   Sahakian, Barbara J.
TI Cognitive Training Using a Novel Memory Game on an iPad in Patients with
   Amnestic Mild Cognitive Impairment (aMCI)
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE mild cognitive impairment; episodic memory; paired associates learning;
   cognitive training; motivation
ID ALZHEIMERS-DISEASE; OLDER-ADULTS; DIAGNOSIS; DEMENTIA; INTERVENTION;
   NEUROSCIENCE; ASSOCIATION; DEPRESSION
AB Background: Cognitive training is effective in patients with mild cognitive impairment but does not typically address the motivational deficits associated with older populations with memory difficulties.
   Methods: We conducted a randomized controlled trial of cognitive training using a novel memory game on an iPad in 42 patients with a diagnosis of amnestic mild cognitive impairment assigned to either the cognitive training (n = 21; 8 hours of gameplay over 4 weeks) or control (n = 21; clinic visits as usual) groups.
   Results: Significant time-by-pattern-by-group interactions were found for cognitive performance in terms of the number of errors made and trials needed on the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning task (P = .044; P = .027). Significant time-by-group interactions were also found for the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning first trial memory score (P = .002), Mini-Mental State Examination (P = .036), the Brief Visuospatial Memory Test (P = .032), and the Apathy Evaluation Scale (P = .026). Within-group comparisons revealed highly specific effects of cognitive training on episodic memory. The cognitive training group maintained high levels of enjoyment and motivation to continue after each hour of gameplay, with self-confidence and self-rated memory ability improving over time.
   Conclusions: Episodic memory robustly improved in the cognitive training group. "Gamified" cognitive training may also enhance visuospatial abilities in patients with amnestic mild cognitive impairment. Gamification maximizes engagement with cognitive training by increasing motivation and could complement pharmacological treatments for amnestic mild cognitive impairment and mild Alzheimer's disease. Larger, more controlled trials are needed to replicate and extend these findings.
C1 [Savulich, George; Piercy, Thomas; Suckling, John; O'Brien, John T.; Sahakian, Barbara J.] Univ Cambridge, Dept Psychiat, Herchel Smith Bldg Brain & Mind Sci,Forvie Site, Cambridge CB2 0SZ, England.
   [Savulich, George; Piercy, Thomas; Suckling, John; Rowe, James B.; Sahakian, Barbara J.] Univ Cambridge, MRC, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge, England.
   [Fox, Chris] Univ East Anglia, Dept Psychol Sci, Norwich, Norfolk, England.
   [Rowe, James B.] Univ Cambridge, Dept Clin Neurosci, Cambridge, England.
   [Rowe, James B.] Univ Cambridge, MRC Cognit & Brain Sci Unit, Cambridge, England.
C3 University of Cambridge; University of Cambridge; University of East
   Anglia; University of Cambridge; University of Cambridge
RP Sahakian, BJ (corresponding author), Univ Cambridge, Dept Psychiat, Herchel Smith Bldg Brain & Mind Sci,Forvie Site, Cambridge CB2 0SZ, England.
EM bjs1001@medschl.cam.ac.uk
RI Savulich, George/O-1376-2018; Sahakian, Barbara/AAW-1198-2020; Tick,
   Beata/ABA-1728-2020; Suckling, John/ABD-7246-2021; Rowe,
   James/C-3661-2013
OI Savulich, George/0000-0002-6513-5454; Sahakian,
   Barbara/0000-0001-7352-1745; Suckling, John/0000-0002-5098-1527; Fox,
   Chris/0000-0001-9480-5704; O'Brien, John/0000-0002-0837-5080; Rowe,
   James/0000-0001-7216-8679
FU Janssen Pharmaceutica/Johnson Johnson [71418]; NIHR Biomedical Research
   Centre (Neurodegeneration; Mental Health), Cambridge; Wellcome Trust
   [103838]; Eton College; Wallitt Foundation; Medical Research Council
   [MC_U105597119, MC_UU_00005/12] Funding Source: researchfish; Wellcome
   Trust [103838/Z/14/Z] Funding Source: researchfish; MRC [MC_U105597119,
   MC_UU_00005/12] Funding Source: UKRI
FX This work was supported by a grant from Janssen Pharmaceutica/Johnson &
   Johnson (71418) awarded to Barbara J. Sahakian and the NIHR Biomedical
   Research Centre (Neurodegeneration; Mental Health), Cambridge. James B.
   Rowe is supported by the Wellcome Trust (103838). George Savulich is
   currently funded by a grant from Eton College and the Wallitt
   Foundation.
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NR 49
TC 60
Z9 65
U1 3
U2 50
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD AUG
PY 2017
VL 20
IS 8
BP 624
EP 633
DI 10.1093/ijnp/pyx040
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA FF2GR
UT WOS:000408716400003
PM 28898959
OA gold, Green Published, Green Accepted, Green Submitted
DA 2023-08-17
ER

PT J
AU Hernes, SS
   Flak, MM
   Lohaugen, GCC
   Skranes, J
   Hol, HR
   Madsen, BO
   Knapskog, AB
   Engvig, A
   Pripp, A
   Ulstein, I
   Lona, T
   Zhang, X
   Chang, LD
AF Hernes, Susanne S.
   Flak, Marianne M.
   Lohaugen, Gro C. C.
   Skranes, Jon
   Hol, Haakon R.
   Madsen, Bengt-Ove
   Knapskog, Anne-Brita
   Engvig, Andreas
   Pripp, Are
   Ulstein, Ingun
   Lona, Trine
   Zhang, Xin
   Chang, Linda
TI Working Memory Training in Amnestic and Non-amnestic Patients With Mild
   Cognitive Impairment: Preliminary Findings From Genotype Variants on
   Training Effects
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE MCI; Alzheimer; working memory training; APOE genotype; LMX1A
AB Working memory training (WMT) effects may be modulated by mild cognitive impairment (MCI) subtypes, and variations in APOE-epsilon (APOE-epsilon) and LMX1A genotypes. Sixty-one individuals (41 men/20 women, mean age 66 years) diagnosed with MCI (31 amnestic/30 non-amnestic) and genotyped for APOE-epsilon and LMX1A completed 4 weeks/20-25 sessions of WMT. Cognitive functions were assessed before, 4 weeks and 16 weeks after WMT. Except for Processing Speed, the non-amnestic MCI group (naMCI) outperformed the amnestic MCI (aMCI) group in all cognitive domains across all time-points. At 4 weeks, working memory function improved in both groups (p < 0.0001), but at 16 weeks the effects only remained in the naMCI group. Better performance was found after training for the naMCI patients with LMX1A-AA genotype and for the APOE-epsilon 4 carriers. Only the naMCI-APOE-epsilon 4 group showed improved Executive Function at 16 weeks. WMT improved working memory and some non-trained cognitive functions in individuals with MCI. The naMCI group had greater training gain than aMCI group, especially in those with LMX1A-AA genotype and among APOE-epsilon 4-carriers. Further research with larger sample sizes for the subgroups and longer follow-up evaluations is warranted.
C1 [Hernes, Susanne S.; Madsen, Bengt-Ove] Sorlandet Hosp, Dept Geriatr & Internal Med, Arendal, Norway.
   [Hernes, Susanne S.; Hol, Haakon R.] Univ Bergen, Dept Clin Sci, Bergen, Norway.
   [Flak, Marianne M.; Skranes, Jon] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [Flak, Marianne M.; Lohaugen, Gro C. C.; Skranes, Jon] Sorlandet Hosp HF, Dept Pediat, Arendal, Norway.
   [Hol, Haakon R.] Sorlandet Hosp HF, Dept Radiol, Arendal, Norway.
   [Knapskog, Anne-Brita; Ulstein, Ingun] Oslo Univ Hosp, Dept Geriatr Med, Memory Clin, Oslo, Norway.
   [Engvig, Andreas] Diakonhjemmet Hosp, Dept Med, Oslo, Norway.
   [Pripp, Are] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol Res Support Serv, Oslo, Norway.
   [Lona, Trine] Hosp Telemark, Dept Psychiat, Age Psychiat, Skien, Norway.
   [Zhang, Xin; Chang, Linda] Univ Maryland, Sch Med, Dept Diagnost Radiol & Nucl Med, Baltimore, MD 21201 USA.
   [Zhang, Xin; Chang, Linda] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA.
   [Chang, Linda] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
   [Chang, Linda] Univ Hawaii Manoa, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA.
C3 University of Bergen; Norwegian University of Science & Technology
   (NTNU); University of Oslo; Diakonhjemmet Hospital; University of Oslo;
   Telemark Hospital Trust; University System of Maryland; University of
   Maryland Baltimore; University System of Maryland; University of
   Maryland Baltimore; Johns Hopkins University; University of Hawaii
   System; University of Hawaii Manoa
RP Hernes, SS (corresponding author), Sorlandet Hosp, Dept Geriatr & Internal Med, Arendal, Norway.; Hernes, SS (corresponding author), Univ Bergen, Dept Clin Sci, Bergen, Norway.; Chang, LD (corresponding author), Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA.; Chang, LD (corresponding author), Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.; Chang, LD (corresponding author), Univ Hawaii Manoa, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA.
EM Susanne.sorensen.hernes@sshf.no; LChang@som.umaryland.edu
RI Hol, Haakon Ramsland/AAC-7388-2022; Engvig, Andreas/HMV-2110-2023
OI Hol, Haakon Ramsland/0000-0001-5625-8308
FU South Eastern Norway Regional Health Authority [2013059]; Fulbright
   Norway Foundation; University of Maryland, School of Medicine; John A.
   Burns School of Medicine at the University of Hawai'i at Manoa
FX This study was funded by a research grant from the South Eastern Norway
   Regional Health Authority (2013059) and by the Fulbright Norway
   Foundation (fe7e0da15bfc05ab6e075c6f97cfb65c). Dr. Chang's effort was
   supported by the University of Maryland, School of Medicine, and the
   John A. Burns School of Medicine at the University of Hawai'i at Manoa.
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NR 57
TC 3
Z9 3
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD FEB 15
PY 2021
VL 13
AR 624253
DI 10.3389/fnagi.2021.624253
PG 14
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA QO5VD
UT WOS:000623208900001
PM 33658917
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Hill, NTM
   Mowszowski, L
   Naismith, SL
   Chadwick, VL
   Valenzuela, M
   Lampit, A
AF Hill, Nicole T. M.
   Mowszowski, Loren
   Naismith, Sharon L.
   Chadwick, Verity L.
   Valenzuela, Michael
   Lampit, Amit
TI Computerized Cognitive Training in Older Adults With Mild Cognitive
   Impairment or Dementia: A Systematic Review and Meta-Analysis
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID ALZHEIMERS ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL
   INSTITUTE; EXECUTIVE FUNCTION; HONG-KONG; DISEASE; EFFICACY; MEMORY;
   RISK; REHABILITATION
AB Objective: Previous meta-analyses indicate that computerized cognitive training (CCT) is a safe and efficacious intervention for cognition in older adults. However, efficacy varies across populations and cognitive domains, and little is known about the efficacy of CCT in people with mild cognitive impairment or dementia.
   Method: The authors searched Medline, Embase, PsychINFO, CINAHL, and CENTRAL through July 1, 2016, for randomized controlled trials of CCT in older adults with mild cognitive impairment or dementia. Overall cognition, individual cognitive domains, psychosocial function, and activities of daily living were pooled separately for mild cognitive impairment and dementia trials.
   Results: The overall effect on cognition in mild cognitive impairment across 17 trials was moderate (Hedges' g=0.35, 95% CI=0.20-0.51). There was no evidence of publication bias or difference between active-and passive-controlled trials. Small to moderate effects were found for global cognition, attention, working memory, learning, and memory, with the exception of nonverbal memory, and for psychosocial functioning, including depressive symptoms. In dementia, statistically significant effects were found on overall cognition (k=11, g=0.26, 95% CI=0.01-0.52) and visuospatial skills, but these were driven by three trials of virtual reality or Nintendo Wii.
   Conclusions: CCT is efficacious on global cognition, select cognitive domains, and psychosocial functioning in people with mild cognitive impairment. This intervention therefore warrants longer-term and larger-scale trials to examine effects on conversion to dementia. Conversely, evidence for efficacy in people with dementia is weak and limited to trials of immersive technologies.
C1 [Lampit, Amit] Univ New South Wales, Black Dog Inst, Sydney, NSW, Australia.
   Univ Sydney, Brain & Mind Ctr, Regenerat Neurosci Grp, Sydney, NSW, Australia.
   Univ Sydney, Brain & Mind Ctr, Hlth Brain Ageing Program, Sydney, NSW, Australia.
   Univ Sydney, Sch Psychol, Sydney, NSW, Australia.
   Univ Sydney, Sch Med Sci, Sydney, NSW, Australia.
C3 Black Dog Institute; University of New South Wales Sydney; University of
   Sydney; University of Sydney; University of Sydney; University of Sydney
RP Lampit, A (corresponding author), Univ New South Wales, Black Dog Inst, Sydney, NSW, Australia.
EM amit.lampit@sydney.edu.au
OI Mowszowski, Loren/0000-0002-7534-5017; Lampit, Amit/0000-0001-6522-8397;
   chadwick, verity/0000-0003-4213-7219; Valenzuela,
   Michael/0000-0001-7162-6607; Hill, Nicole T.M./0000-0003-1987-5299;
   Naismith, Sharon/0000-0001-9076-2778
FU National Health and Medical Research Council of Australia/Australian
   Research Council (NHMRC-ARC) Dementia Research Development Fellowship;
   NHMRC/ARC Dementia Research Development Fellowship
FX Dr. Mowszowski is supported by a National Health and Medical Research
   Council of Australia/Australian Research Council (NHMRC-ARC) Dementia
   Research Development Fellowship. Dr. Naismith is an NHMRC Career
   Development Fellow. Ms. Chadwick is a former employee of Synaptikon. Dr.
   Valenzuela receives in-kind research support in the form of no-cost
   software from Brain Train and Synaptikon for projects unrelated to this
   study; he is also an NHMRC Career Development Fellow. Dr. Lampit is
   supported by an NHMRC/ARC Dementia Research Development Fellowship. Ms.
   Hill reports no financial relationships with commercial interests.
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NR 67
TC 336
Z9 365
U1 12
U2 211
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD APR
PY 2017
VL 174
IS 4
BP 329
EP 340
DI 10.1176/appi.ajp.2016.16030360
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EQ2SU
UT WOS:000397921800009
PM 27838936
OA Bronze
DA 2023-08-17
ER

PT J
AU Moon, SK
   Chung, S
   Han, MI
AF Moon, Seong Keun
   Chung, S.
   Han, M. -Il
TI The effectiveness of self-efficacy based memory training program for the
   elderly with mild cognitive impairment
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Meeting Abstract
C1 [Moon, Seong Keun] Jeongeup Geriatr Hosp, Jeongeup, South Korea.
   [Chung, S.] Jeonbuk Natl Univ Hosp, Jeongeup, South Korea.
   [Han, M. -Il] Maeumsarang Hosp, Wanjoo, South Korea.
C3 Jeonbuk National University; Jeonbuk National University Hospital
NR 0
TC 3
Z9 3
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD OCT
PY 2013
VL 25
SU 1
MA PS02-032
BP S141
EP S142
PG 2
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA AJ5UB
UT WOS:000337753100320
DA 2023-08-17
ER

PT J
AU Irazoki, E
   Contreras-Somoza, LM
   Toribio-Guzman, JM
   Jenaro-Rio, C
   van der Roest, H
   Franco-Martin, MA
AF Irazoki, Eider
   Contreras-Somoza, Leslie Maria
   Toribio-Guzman, Jose Miguel
   Jenaro-Rio, Cristina
   van der Roest, Henriette
   Franco-Martin, Manuel A.
TI Technologies for Cognitive Training and Cognitive Rehabilitation for
   People With Mild Cognitive Impairment and Dementia. A Systematic Review
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE cognitive training; cognitive rehabilitation; software; cognitive
   impairment; dementia; systematic review
ID STIMULATION THERAPY CST; ALZHEIMERS-DISEASE; OLDER-ADULTS; EFFICACY;
   PROGRAM; INTERVENTION; HEALTHY; RESERVE; RISK
AB Due to the growing number of older adults with cognitive impairment, it is essential to delay the onset and progression of cognitive decline and promote a healthy lifestyle. The rapid growth of technology has considerably advanced the field of computerized cognitive interventions. Consequently, traditional cognitive interventions are being adapted and new multimedia systems are being developed to encourage health and independent living in old age. The primary objective of this review was to identify cognitive stimulation, training and rehabilitation programs aimed at older people with mild cognitive impairment (MCI) and dementia. PsycINFO, Medline, CINAHL, Web of Science, PubMed, and CORDIS databases were searched from January 2008 to August 2018. Two researchers reviewed the potential studies individually for eligibility. Studies of computerized cognitive interventions for people with dementia and cognitive impairment were included if they clearly described objectives, users and functioning. A systematic review of the studies was carried out, providing a qualitative synthesis of the features and study characteristics of each software. Nineteen studies met the inclusion criteria, and 11 different cognitive stimulation, training, and rehabilitation programs were identified. The studies found on cognitive intervention software indicate the existence of various technological programs for people with MCI and dementia. On the overall, the programs were aimed at people with different clinical conditions, able to create specific treatments and personalized training, optimized for portable devices, and user-friendly. However, the selected programs differ from each other in terms of objectives, usage mode and characteristics, even if they were used for the same purposes. Therefore, the information obtained in the review may be relevant to distinguish between programs and select the one that best suits each user. Thus, more information about the features and context of use is needed as well as more clinical studies to be able to compare among computerized cognitive programs.
C1 [Irazoki, Eider; Contreras-Somoza, Leslie Maria; Jenaro-Rio, Cristina; Franco-Martin, Manuel A.] Univ Salamanca, Fac Psychol, Salamanca, Spain.
   [Irazoki, Eider; Contreras-Somoza, Leslie Maria; Toribio-Guzman, Jose Miguel] INTRAS Fdn, Iberian Res Psychosci Inst, Dept Res & Dev, Zamora, Spain.
   [van der Roest, Henriette] Netherlands Inst Mental Hlth & Addict, Dept Aging, Trimbos Inst, Utrecht, Netherlands.
   [Franco-Martin, Manuel A.] Univ Rio Hortega Hosp, Dept Psychiat, Valladolid, Spain.
   [Franco-Martin, Manuel A.] Zamora Hosp, Zamora, Spain.
C3 University of Salamanca; Trimbos Institute; Hospital del Rio Hortega
RP Irazoki, E (corresponding author), Univ Salamanca, Fac Psychol, Salamanca, Spain.; Irazoki, E (corresponding author), INTRAS Fdn, Iberian Res Psychosci Inst, Dept Res & Dev, Zamora, Spain.
EM eider.irazoki@usal.es
RI Jenaro, Cristina/H-6386-2013; Toribio-Guzmán, José Miguel/HMP-7789-2023;
   Franco-Martin, Manuel/D-1752-2011
OI Jenaro, Cristina/0000-0003-2060-1658; Franco-Martin,
   Manuel/0000-0002-3639-2523; Toribio-Guzman, Jose
   Miguel/0000-0002-5678-3150; Irazoki, Eider/0000-0002-7716-3989;
   Contreras Somoza, Leslie Maria/0000-0002-9232-6918
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NR 69
TC 39
Z9 40
U1 11
U2 42
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD APR 9
PY 2020
VL 11
AR 648
DI 10.3389/fpsyg.2020.00648
PG 15
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA LJ1XW
UT WOS:000529966000001
PM 32373018
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Beishon, L
   Intharakham, K
   Swienton, D
   Panerai, RB
   Robinson, TG
   Haunton, VJ
AF Beishon, Lucy
   Intharakham, Kannakorn
   Swienton, David
   Panerai, Ronney B.
   Robinson, Thompson G.
   Haunton, Victoria J.
TI Neuroimaging Outcomes in Studies of Cognitive Training in Mild Cognitive
   Impairment and Early Alzheimer's Disease: A Systematic Review
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Review
DE Cognitive impairment; brain training; brain imaging; MCI; Alzheimer's
   disease; vascular cognitive impairment
ID HEMISPHERIC-ASYMMETRY REDUCTION; OLDER-ADULTS; FUNCTIONAL CONNECTIVITY;
   SCAFFOLDING THEORY; BRAIN; DEMENTIA; DIAGNOSIS; NETWORKS; MODEL; MRI
AB Background: Cognitive Training (CT) has demonstrated some benefits to cognitive and psychosocial function in Mild Cognitive Impairment (MCI) and early dementia, but the certainty related to those findings remains unclear. Therefore, understanding the mechanisms by which CT improves cognitive functioning may help to understand the relationships between CT and cognitive function.
   The purpose of this review was to identify the evidence for neuroimaging outcomes in studies of CT in MCI and early Alzheimer's Disease (AD).
   Methods: Medline, Embase, Web of Science, PsycINFO, CINAHL, and The Cochrane Library were searched with a predefined search strategy, which yielded 1778 articles. Studies were suitable for inclusion where a CT program was used in patients with MCI or AD, with a structural or functional Magnetic Resonance Imaging (MRI) outcome. Studies were assessed for quality using the Downs and Black criteria.
   Results: A total of 19 studies met the inclusion criteria. Quality of the included studies was variable and there was significant heterogeneity for studies included in this review. Task activation was generally increased post-training, but functional connectivity was both increased and decreased after training. Re-suits varied by diagnosis, type of CT program, and brain networks examined. No effects were seen on hippocampal volumes post-training, but cortical thickening and increased grey matter volumes were demonstrated.
   Conclusions: CT resulted in variable functional and structural changes in dementia, and conclusions are limited by heterogeneity and study quality. Larger, more robust studies are required to correlate these findings with clinical benefits from CT.
C1 [Beishon, Lucy; Intharakham, Kannakorn; Panerai, Ronney B.; Robinson, Thompson G.; Haunton, Victoria J.] Univ Leicester, Dept Cardiovasc Sci, Leicester LE1 7RH, Leics, England.
   [Panerai, Ronney B.; Robinson, Thompson G.; Haunton, Victoria J.] Glenfield Hosp, British Heart Fdn Cardiovasc Res Ctr, NIHR Leicester Biomed Res Ctr, Leicester LE1 7RH, Leics, England.
   [Swienton, David] Univ Hosp Leicester NHS Trust, Dept Radiol, Leicester LE1 7RH, Leics, England.
C3 University of Leicester; University Hospitals of Leicester NHS Trust;
   University of Leicester; Glenfield Hospital; University Hospitals of
   Leicester NHS Trust; University of Leicester
RP Beishon, L (corresponding author), Univ Leicester, Dept Cardiovasc Sci, Leicester LE1 7RH, Leics, England.
EM Lb330@le.ac.uk
OI Ladthavorlaphatt, Kannaphob/0000-0003-3588-3619; Robinson,
   Thompson/0000-0003-2144-2468; Haunton, Victoria/0000-0001-6078-5469
FU Dunhill Medical Trust [RTF1806\27]
FX LB is a research training fellow funded by the Dunhill Medical Trust
   (RTF1806\27). TGR is an NIHR Senior Investigator.
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NR 78
TC 7
Z9 7
U1 3
U2 13
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PY 2020
VL 17
IS 5
BP 472
EP 486
DI 10.2174/1567205017666200624202425
PG 15
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA ND0US
UT WOS:000561623900006
PM 32579501
DA 2023-08-17
ER

PT J
AU Sun, JX
   Zeng, H
   Pan, L
   Wang, XS
   Liu, MJ
AF Sun, Jingxian
   Zeng, Hui
   Pan, Lu
   Wang, Xiaosong
   Liu, Mengjiao
TI Acupressure and Cognitive Training Can Improve Cognitive Functions of
   Older Adults With Mild Cognitive Impairment: A Randomized Controlled
   Trial
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE older adult; mild cognitive impairment; acupressure; cognitive training;
   cognitive function
ID ALZHEIMERS-DISEASE; CONNECTIVITY; INTERVENTION; METAANALYSIS;
   ACUPUNCTURE; DEMENTIA; EFFICACY; STRESS; HOME
AB Background: Given the limited effectiveness of pharmacological treatments in mitigating cognitive decline in individuals with mild cognitive impairment (MCI), there is a pressing need for developing effective non-pharmacological intervention programs to counteract MCI-related cognitive decline. Acupressure and cognitive training are safe and cost-effective; however, evidence of the effect of acupressure or the combined effect of acupressure and cognitive training on cognitive functions of older adults with MCI is limited.Objective: To evaluate both the individual and combined effects of acupressure and cognitive training on cognitive functions of older adults with MCI.Methods: One hundred and eighty older adults with MCI were recruited and randomly assigned to combined acupressure and cognitive training group (n = 45), acupressure group (n = 45), cognitive training group (n = 45), or control group (n = 45). Participants in the experimental groups received self-administered and group-based training sessions, while those in the control group received routine community education. The intervention lasted for 6 months. The cognitive functions of all the participants were assessed at multiple stages, including pre-intervention, at the end of the third and sixth months.Results: One hundred and fifty-one participants completed the study, and all participants analyzed in intervention groups completed at least 85% of all practice sessions recommended. Repeated measures analysis of variance of the scores of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at different time points among the four groups revealed that the group effect, time effect, and interaction effect were all significant (p < 0.01). Pairwise comparisons with Bonferroni correction showed that the scores of MMSE and MoCA in acupressure group, cognitive training group, and combined group were significantly raised compared with control group (p < 0.01). Compared with acupressure or cognitive training groups, the scores of MMSE and MoCA in combined group were significantly higher (p < 0.05). The scores of MMSE and MoCA in acupressure group had no significant differences with those in cognitive training group (p > 0.05).Conclusion: Acupressure and cognitive training both could improve the cognitive functions of older adults with MCI, and when used together, the effects were enhanced.
C1 [Sun, Jingxian] Nanjing Univ Chinese Med, Sch Nursing, Nanjing, Peoples R China.
   [Zeng, Hui] Cent South Univ, Xiangya Sch Nursing, Changsha, Peoples R China.
   [Pan, Lu; Liu, Mengjiao] Cent South Univ, Xiangya Hosp 2, Changsha, Peoples R China.
   [Wang, Xiaosong] Jiangxi Prov Canc Hosp, Nanchang, Jiangxi, Peoples R China.
C3 Nanjing University of Chinese Medicine; Central South University;
   Central South University
RP Zeng, H (corresponding author), Cent South Univ, Xiangya Sch Nursing, Changsha, Peoples R China.
EM zenghui@csu.edu.cn
RI Sun, Jingxian/ABE-8640-2020; 刘, 梦姣/HRM-5532-2023
OI Sun, Jingxian/0000-0001-7557-156X; 
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NR 61
TC 5
Z9 5
U1 2
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD NOV 17
PY 2021
VL 12
AR 726083
DI 10.3389/fpsyg.2021.726083
PG 12
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA XH9MA
UT WOS:000725748500001
PM 34867607
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Nousia, A
   Martzoukou, M
   Siokas, V
   Aretouli, E
   Aloizou, AM
   Folia, V
   Peristeri, E
   Messinis, L
   Nasios, G
   Dardiotis, E
AF Nousia, Anastasia
   Martzoukou, Maria
   Siokas, Vasileios
   Aretouli, Eleni
   Aloizou, Athina-Maria
   Folia, Vasiliki
   Peristeri, Eleni
   Messinis, Lambros
   Nasios, Grigorios
   Dardiotis, Efthimios
TI Beneficial effect of computer-based multidomain cognitive training in
   patients with mild cognitive impairment
SO APPLIED NEUROPSYCHOLOGY-ADULT
LA English
DT Article
DE Computer-based cognitive training; mild cognitive impairment;
   multidomain; RehaCom software; neuropsychological performance
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; REHABILITATION PROGRAM; NORMATIVE
   DATA; GREEK POPULATION; VERBAL FLUENCY; MEMORY; EFFICACY; DEMENTIA; MCI
AB The purpose of the present study was to explore the effects of computer-based multidomain cognitive training program on Greek patients with Mild Cognitive Impairment (MCI). Forty-six patients with MCI were randomly divided into two groups; (a) the training group, which received a computer-based multidomain cognitive training program with the use of the RehaCom software and (b) the control group, which underwent standard-clinical care. The duration of the computer-based training program was 15 weeks, administered twice a week for approximately one hour per session. Analysis of the baseline versus endpoint performance of each group demonstrated that in the control group delayed memory and executive function had deteriorated over the observation period of 15 weeks, while improvement was observed in the training group's performance on delayed memory, word recognition, Boston Naming Test (BNT), Clock Drawing Test (CDT), Semantic Fluency (SF), Trail Making Test-A (TMT-A) and Trail Making Test-B (TMT-B). Comparison between the two groups presented asignificant effect of the intervention for most cognitive domains. These findings are promising for the development of training methods designed to delay cognitive decline in patients with MCI, which is considered to be the prodromal stage of Alzheimer's Disease (AD).
C1 [Nousia, Anastasia; Martzoukou, Maria; Nasios, Grigorios] Univ Ioannina, Dept Speech & Language Therapy, 4th Km Ioannina Athens, GR-45500 Ioannina, Greece.
   [Siokas, Vasileios; Aloizou, Athina-Maria; Folia, Vasiliki; Peristeri, Eleni; Dardiotis, Efthimios] Univ Hosp Larissa, Dept Neurol, Larisa, Greece.
   [Siokas, Vasileios; Aloizou, Athina-Maria; Folia, Vasiliki; Peristeri, Eleni; Dardiotis, Efthimios] Univ Thessaly, Sch Hlth Sci, Fac Med, Larisa, Greece.
   [Aretouli, Eleni] Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Greece.
   [Messinis, Lambros] Univ Patras, Sch Med, Dept Neurol, Neuropsychol Sect, Patras, Greece.
C3 University of Ioannina; General University Hospital of Larissa;
   University of Thessaly; Aristotle University of Thessaloniki; University
   of Patras
RP Nousia, A (corresponding author), Univ Ioannina, Dept Speech & Language Therapy, 4th Km Ioannina Athens, GR-45500 Ioannina, Greece.
EM sialogo@gmail.com
RI Aretouli, eleni/HMV-0909-2023; Messinis, Lambros/HIK-2587-2022
OI Aloizou, Athina Maria/0000-0001-9354-774X; Dardiotis,
   Efthimios/0000-0003-2957-641X; Folia, Vasiliki/0000-0002-2159-7032
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NR 83
TC 14
Z9 15
U1 0
U2 14
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 2327-9095
EI 2327-9109
J9 APPL NEUROPSYCH-ADUL
JI Appl. Neuropsychol.-Adult
PD NOV 2
PY 2021
VL 28
IS 6
BP 717
EP 726
DI 10.1080/23279095.2019.1692842
EA NOV 2019
PG 10
WC Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychology
GA WC3NK
UT WOS:000504626700001
PM 31885287
DA 2023-08-17
ER

PT J
AU Lawrence, BJ
   Gasson, N
   Johnson, AR
   Booth, L
   Loftus, AM
AF Lawrence, Blake J.
   Gasson, Natalie
   Johnson, Andrew R.
   Booth, Leon
   Loftus, Andrea M.
TI Cognitive Training and Transcranial Direct Current Stimulation for Mild
   Cognitive Impairment in Parkinson's Disease: A Randomized Controlled
   Trial
SO PARKINSONS DISEASE
LA English
DT Article
ID QUALITY-OF-LIFE; MEMORY; VALIDATION; NETWORKS; EFFICACY; CRITERIA;
   SCALE; TDCS
AB This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group. Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up.) e trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673). While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge's g range = 0.01 to 1.75). More outcomes improved for the groups that received standard or tailored cognitive training combined with tDCS. Participants with PD-MCI receiving cognitive training (standard or tailored) or tDCS demonstrated significant improvements on cognitive and functional outcomes, and combining these interventions provided greater therapeutic effects.
C1 [Lawrence, Blake J.; Gasson, Natalie; Johnson, Andrew R.; Booth, Leon; Loftus, Andrea M.] Curtin Univ, Sch Psychol & Speech Pathol, Curtin Neurosci Lab, Bentley, WA 6102, Australia.
   [Lawrence, Blake J.; Gasson, Natalie; Johnson, Andrew R.; Booth, Leon; Loftus, Andrea M.] Curtin Univ, ParkC Collaborat Res Grp, Bentley, WA 6102, Australia.
   [Lawrence, Blake J.] Ear Sci Inst Australia, Subiaco, WA, Australia.
   [Lawrence, Blake J.] Univ Western Australia, Sch Surg, Ear Sci Ctr, Crawley, WA, Australia.
C3 Curtin University; Curtin University; Ear Science Institute Australia;
   University of Western Australia
RP Lawrence, BJ (corresponding author), Curtin Univ, Sch Psychol & Speech Pathol, Curtin Neurosci Lab, Bentley, WA 6102, Australia.; Lawrence, BJ (corresponding author), Curtin Univ, ParkC Collaborat Res Grp, Bentley, WA 6102, Australia.; Lawrence, BJ (corresponding author), Ear Sci Inst Australia, Subiaco, WA, Australia.; Lawrence, BJ (corresponding author), Univ Western Australia, Sch Surg, Ear Sci Ctr, Crawley, WA, Australia.
EM blake.lawrence@earscience.org.au
RI Lawrence, Blake/C-6069-2016; Booth, Leon/HKE-4858-2023; Loftus,
   Andrea/IQV-5269-2023
OI Lawrence, Blake/0000-0002-8772-8226; Booth, Leon/0000-0002-6326-1908;
   Johnson, Andrew/0000-0001-7000-8065
FU Parkinson's Western Australia Inc.
FX The authors thank the participants for giving up their time to take part
   in the research and Parkinson's Western Australia Inc. for providing
   funding to support this research.
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NR 45
TC 41
Z9 44
U1 1
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-8083
EI 2042-0080
J9 PARKINSONS DIS-US
JI Parkinsons Dis.
PY 2018
VL 2018
AR 4318475
DI 10.1155/2018/4318475
PG 12
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GC4AZ
UT WOS:000429726300001
PM 29780572
OA Green Published, gold, Green Submitted
DA 2023-08-17
ER

PT J
AU Finn, M
   McDonald, S
AF Finn, Maurice
   McDonald, Skye
TI Computerised Cognitive Training for Older Persons With Mild Cognitive
   Impairment: A Pilot Study Using a Randomised Controlled Trial Design
SO BRAIN IMPAIRMENT
LA English
DT Article
DE human; aged; cognition; cognitive training; mild cognitive impairment;
   randomised controlled trial
ID TEMPORAL-LOBE EXCISIONS; MEMORY FUNCTIONING QUESTIONNAIRE;
   AMYGDALO-HIPPOCAMPECTOMY; REHABILITATION PROGRAM; ALZHEIMERS-DISEASE;
   DEMENTIA; OUTCOMES; ADULTS; BRAIN; INTERVENTIONS
AB The results of a pilot randomised controlled trial of computerised cognitive training in older adults with mild cognitive impairment (MCI) are reported. Participants (N = 25) were randomised into either the treatment or waitlist training groups. Sixteen participants completed the 30-session computerised cognitive training program using exercises that target a range of cognitive functions including attention, processing speed, visual memory and executive functions. It was hypothesised that participants would improve with practice on the trained tasks, that the benefits of training would generalise to nontrained neuropsychological measures, and that training would result in improved perceptions of memory and memory functioning when compared with waitlist controls. Results indicated that participants were able to improve their performance across a range of tasks with training. There was some evidence of generalisation of training to a measure of visual sustained attention. There were no significant effects of training on self-reported everyday memory functioning or mood. The results are discussed along with suggestions for future research.
C1 [McDonald, Skye] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia.
C3 University of New South Wales Sydney
RP Finn, M (corresponding author), Royal N Shore Hosp, 2C Herbert St, St Leonards, NSW 2065, Australia.
EM mefinn@nsccahs.health.nsw.gov.au
RI McDonald, Skye/G-4118-2014
OI McDonald, Skye/0000-0003-0723-6094; Finn, Maurice/0000-0001-9491-2366
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NR 47
TC 85
Z9 88
U1 0
U2 66
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1443-9646
EI 1839-5252
J9 BRAIN IMPAIR
JI Brain Impair.
PD DEC
PY 2011
VL 12
IS 3
BP 187
EP 199
PG 13
WC Clinical Neurology; Neurosciences; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Rehabilitation
GA 887FJ
UT WOS:000299912000003
DA 2023-08-17
ER

PT J
AU Yang, HL
   Chu, H
   Kao, CC
   Chiu, HL
   Tseng, IJ
   Tseng, P
   Chou, KR
AF Yang, Hui-Ling
   Chu, Hsin
   Kao, Ching-Chiu
   Chiu, Huei-Ling
   Tseng, Ing-Jy
   Tseng, Philip
   Chou, Kuei-Ru
TI Development and effectiveness of virtual interactive working memory
   training for older people with mild cognitive impairment: a single-blind
   randomised controlled trial
SO AGE AND AGEING
LA English
DT Article
DE Memory training; mild cognitive impairment; working memory; randomised
   controlled trial; older people
ID PERFORMANCE; ADULTS; METAANALYSIS; AGE
AB Background: memory training is a potential intervention for retaining memory and reducing dementia risk in older adults with mild cognitive impairment (MCI).
   Objective: this study examined the effect of virtual interactive working memory training (VIMT) in older adults with MCI.
   Design: single-blind, two-arm parallel-group, randomised controlled design.
   Setting: retirement homes, institutions, and communities.
   Subjects: a total of 66 older adults with MCI were recruited (mean age: 78.5 +/- 7.6 years).
   Methods: participants were randomly assigned to the experimental group (VIMT, n = 33) or active control group (n = 33). The VIMT program used the CogniPlus (includes four training modules). Both groups attended 45 min sessions 3 times per week, a total of 36 sessions. The primary outcome was working memory; secondary outcomes were immediate memory, delayed memory, subjective memory complaints and global cognitive function. All variables were measured at pre-test, post-test, and 3-month follow-up.
   Results: between group, the effect of working memory adjusted mean difference by 1.75 (95% CI: 0.56 to 2.94; P < 0.01) at post-test. The results were analysed by a generalised estimating equation, which indicated that VIMT group significantly improved working memory at post-test (P = 0.01) relative to the active control group.
   Conclusions: the applied VIMT program can enable older adults with MCI to maintain their working memory and reduce the rate of cognitive deterioration.
C1 [Yang, Hui-Ling; Kao, Ching-Chiu; Chou, Kuei-Ru] Taipei Med Univ, Sch Nursing, Coll Nursing, 250 Wu Hsing St, Taipei 110, Taiwan.
   [Chu, Hsin] Natl Def Med Ctr, Inst Aerosp & Undersea Med, Sch Med, Taipei, Taiwan.
   [Chu, Hsin] Triserv Gen Hosp, Natl Def Med Ctr, Dept Neurol, Taipei, Taiwan.
   [Kao, Ching-Chiu] Taipei Med Univ, Wan Fang Hosp, Dept Nursing, Taipei, Taiwan.
   [Chiu, Huei-Ling; Tseng, Ing-Jy] Taipei Med Univ, Sch Gerontol Hlth Management, Coll Nursing, Taipei, Taiwan.
   [Tseng, Philip] Taipei Med Univ, Grad Inst Humanities Med, Taipei, Taiwan.
   [Tseng, Philip] Taipei Med Univ, Grad Inst Mind Brain & Consciousness, Taipei, Taiwan.
   [Tseng, Philip] TMU Shuang Ho Hosp, Brain & Consciousness Res Ctr, New Taipei, Taiwan.
   [Chou, Kuei-Ru] Taipei Med Univ Hosp, Psychiat Res Ctr, Taipei, Taiwan.
   [Chou, Kuei-Ru] Taipei Med Univ, Shuang Ho Hosp, Dept Nursing, Taipei, Taiwan.
C3 Taipei Medical University; National Defense Medical Center; National
   Defense Medical Center; Tri-Service General Hospital; Taipei Medical
   University; Taipei Municipal WanFang Hospital; Taipei Medical
   University; Taipei Medical University; Taipei Medical University; Taipei
   Medical University; Taipei Medical University Hospital; Taipei Medical
   University; Shuang Ho Hospital
RP Chou, KR (corresponding author), Taipei Med Univ, Sch Nursing, Coll Nursing, 250 Wu Hsing St, Taipei 110, Taiwan.
EM kueiru@tmu.edu.tw
RI Tseng, Philip/AAG-4849-2021; Chiu, Huei-Ling/AAC-8161-2020
OI Tseng, Philip/0000-0001-5120-5979; 
FU Ministry of Science and Technology, Taiwan [NSC102-2628-B-038-006-MY3]
FX This study was supported by research grants from the Ministry of Science
   and Technology, Taiwan [NSC102-2628-B-038-006-MY3]. The study funders
   had no role in the design or conduct of the study; collection,
   management, analysis, or interpretation of data; preparation, review, or
   approval of the manuscript; or the decision to submit the manuscript for
   publication.
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NR 30
TC 12
Z9 13
U1 3
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-0729
EI 1468-2834
J9 AGE AGEING
JI Age Ageing
PD JUL
PY 2019
VL 48
IS 4
BP 519
EP 525
DI 10.1093/ageing/afz029
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA JI3NL
UT WOS:000493371900013
PM 30989165
OA Bronze
DA 2023-08-17
ER

PT J
AU Hwang, HR
   Choi, SH
   Yoon, DH
   Yoon, BN
   Suh, YJ
   Lee, D
   Han, IT
   Hong, CG
AF Hwang, Hye Ran
   Choi, Seong Hye
   Yoon, Dae Hyun
   Yoon, Byung-Nam
   Suh, Young Ju
   Lee, DaeHyung
   Han, Im-Tae
   Hong, Chang-Gi
TI The Effect of Cognitive Training in Patients with Mild Cognitive
   Impairment and Early Alzheimer's Disease: A Preliminary Study
SO JOURNAL OF CLINICAL NEUROLOGY
LA English
DT Article
DE Alzheimer's disease; cognitive therapy; memory; mild cognitive
   impairment; training
ID OLDER-ADULTS; MEMORY; REHABILITATION; INTERVENTION; INDIVIDUALS;
   BENEFITS; MCI
AB Background and Purpose The objective of this study was to determine the benefits of cognitive training in patients with amnestic mild cognitive impairment (aMCI) and those with early Alzheimer's disease (AD).
   Methods Eleven patients with aMCI and nine with early AD (stage 4 on the Global Deterioration Scale) participated in this study. Six participants with aMCI and six with AD were allocated to the cognitive training group, while five participants with aMCI and three with AD were allocated to a wait-list control group. Multicomponent cognitive training was administered in 18 weekly, individual sessions. Outcome measures were undertaken at baseline, and at 2 weeks and 3 months of follow-up.
   Results In the trained MCI group, there were significant improvements in the delayed-recall scores on the Seoul Verbal Learning Test at both the 2-week and 3-month follow-ups compared with baseline (baseline, 1.6 +/- 1.5; 2 weeks, 4.4 +/- 1.5, p=0.04; 3 months, 4.6 +/- 2.3, p=0.04). The phonemic fluency scores (1.0 +/- 0.8 vs. 5.0 +/- 1.8, p=0.07) and Korean Mini-Mental State Examination scores (18.8 +/- 0.5 vs. 23.8 +/- 2.2, p=0.07) also showed a tendency toward improvement at the 2-week follow-up compared to baseline in the trained AD group.
   Conclusions This study provides evidence of the effectiveness of cognitive training in aMCI and early AD. The efficacy of cognitive training programs remains to be verified in studies with larger samples and a randomized design. J Clin Neurol 2012;8:190-197
C1 [Hwang, Hye Ran; Choi, Seong Hye; Yoon, Byung-Nam; Han, Im-Tae; Hong, Chang-Gi] Inha Univ, Sch Med, Dept Neurol, Inchon 400711, South Korea.
   [Yoon, Dae Hyun] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr,Dept Psychiat, Seoul, South Korea.
   [Yoon, Byung-Nam] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea.
   [Suh, Young Ju] Inha Univ, Sch Med, Clin Res Inst, Inchon 400711, South Korea.
   [Lee, DaeHyung] Inha Univ Hosp, Clin Trial Ctr, Inchon 400711, South Korea.
C3 Inha University; Seoul National University (SNU); Seoul National
   University Hospital; Seoul National University (SNU); Seoul National
   University Hospital; Inha University; Inha University; Inha University
   Hospital
RP Choi, SH (corresponding author), Inha Univ, Sch Med, Dept Neurol, 27 Inhang Ro, Inchon 400711, South Korea.
EM seonghye@inha.ac.kr
RI Suh, Young Ju/AAD-5737-2021; Yoon, Dae Hyun/C-4302-2013
FU Korea Healthcare technology RD Project; Ministry of Health and Welfare,
   Republic of Korea [A102065]; Mita University
FX This study was supported by grants of the Korea Healthcare technology
   R&D Project, the Ministry of Health and Welfare, Republic of Korea
   (A102065), and Mita University.
CR Ahn HJ, 2010, J KOREAN MED SCI, V25, P1071, DOI 10.3346/jkms.2010.25.7.1071
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NR 32
TC 25
Z9 27
U1 0
U2 18
PU KOREAN NEUROLOGICAL ASSOC
PI SEOUL
PA 1111 DAEIL BLD, 43 INSA-DONG, JONGNO-GU, SEOUL, 110-741, SOUTH KOREA
SN 1738-6586
EI 2005-5013
J9 J CLIN NEUROL
JI J. Clin. Neurol.
PD SEP
PY 2012
VL 8
IS 3
BP 190
EP 197
DI 10.3988/jcn.2012.8.3.190
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 016BG
UT WOS:000309491700005
PM 23091528
OA gold, Green Published, Green Submitted
DA 2023-08-17
ER

PT J
AU Hampstead, BM
   Stringer, AY
   Stilla, RF
   Deshpande, G
   Hu, XP
   Moore, AB
   Sathian, K
AF Hampstead, Benjamin M.
   Stringer, Anthony Y.
   Stilla, Randall F.
   Deshpande, Gopikrishna
   Hu, Xiaoping
   Moore, Anna Bacon
   Sathian, K.
TI Activation and Effective Connectivity Changes Following Explicit-Memory
   Training for Face-Name Pairs in Patients With Mild Cognitive Impairment:
   A Pilot Study
SO NEUROREHABILITATION AND NEURAL REPAIR
LA English
DT Article
DE cognitive rehabilitation; mnemonic strategy; Alzheimer disease; aging;
   functional magnetic resonance imaging (fMRI); Granger causality analysis
ID GRANGER CAUSALITY ANALYSIS; ALZHEIMERS-DISEASE; EPISODIC MEMORY;
   FUNCTIONAL MRI; PARIETAL CORTEX; WORKING-MEMORY; OLDER-ADULTS;
   REHABILITATION; FMRI; REGIONS
AB Background. Mild cognitive impairment (MCI) is often a precursor to Alzheimer disease. Little research has examined the efficacy of cognitive rehabilitation in patients with MCI, and the relevant neural mechanisms have not been explored. The authors previously showed the behavioral efficacy of cognitive rehabilitation using mnemonic strategies for face-name associations in patients with MCI. Here, the authors used functional magnetic resonance imaging (fMRI) to test whether there were training-specific changes in activation and connectivity within memory-related areas. Methods. A total of 6 patients with amnestic, multidomain MCI underwent pretraining and posttraining fMRI scans, during which they encoded 90 novel face-name pairs and completed a 4-choice recognition memory test immediately after scanning. Patients were taught mnemonic strategies for half the face-name pairs during 3 intervening training sessions. Results. Training-specific effects comprised significantly increased activation within a widespread cerebral cortical network involving medial frontal, parietal, and occipital regions; the left frontal operculum and angular gyrus; and regions in the left lateral temporal cortex. Increased activation common to trained and untrained stimuli was found in a separate network involving inferior frontal, lateral parietal, and occipital cortical regions. Effective connectivity analysis using multivariate, correlation-purged Granger causality analysis revealed generally increased connectivity after training, particularly involving the middle temporal gyrus and foci in the occipital cortex and the precuneus. Conclusion. The authors' findings suggest that the effectiveness of explicit-memory training in patients with MCI is associated with training-specific increases in activation and connectivity in a distributed neural system that includes areas involved in explicit memory.
C1 [Sathian, K.] Emory Univ, Sch Med, Dept Rehabil Med, Atlanta, GA 30322 USA.
   [Stringer, Anthony Y.; Sathian, K.] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA.
   [Stilla, Randall F.; Sathian, K.] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA.
   [Deshpande, Gopikrishna; Hu, Xiaoping] Emory Univ, Coulter Dept Biomed Engn, Atlanta, GA 30322 USA.
   [Deshpande, Gopikrishna; Hu, Xiaoping] Georgia Inst Technol, Atlanta, GA 30332 USA.
   [Hampstead, Benjamin M.; Moore, Anna Bacon; Sathian, K.] Atlanta VAMC, Rehabil R&D Ctr Excellence, Decatur, GA USA.
C3 Emory University; Emory University; Emory University; Emory University;
   University System of Georgia; Georgia Institute of Technology; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Atlanta VA Health Care System
RP Sathian, K (corresponding author), Emory Univ, Sch Med, Dept Rehabil Med, WMB 6000,101 Woodruff Circle, Atlanta, GA 30322 USA.
EM krish.sathian@emory.edu
OI Deshpande, Gopikrishna/0000-0001-7471-5357; Hu,
   Xiaoping/0000-0001-7014-5983; Hampstead, Benjamin/0000-0003-2717-6375;
   Sathian, Krish/0000-0001-9495-2499
FU Department of Veterans Affairs; Veterans Health Administration; Office
   of Research and Development; Rehabilitation Research and Development
   Service [B4602H, B6366W, B3323K, B4954N]; Atlanta VAMC RR&D Center of
   Excellence; Atlanta VAMC; National Institutes of Health (NIH) [K24
   EY017332, R01EB002009]; Georgia Research Alliance
FX The author(s) disclosed receipt of the following financial support for
   the research and/or authorship of this article: This material is based
   on work supported by the Department of Veterans Affairs, Veterans Health
   Administration, Office of Research and Development, and Rehabilitation
   Research and Development Service through grants B4602H and B6366W to BH,
   and B3323K and B4954N to AM. This work was also funded by the Atlanta
   VAMC RR&D Center of Excellence. Support to KS from the Atlanta VAMC and
   from National Institutes of Health (NIH) grant K24 EY017332 and to XH
   from Georgia Research Alliance and NIH grant R01EB002009 is also
   gratefully acknowledged.
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NR 61
TC 104
Z9 106
U1 0
U2 29
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1545-9683
J9 NEUROREHAB NEURAL RE
JI Neurorehabil. Neural Repair
PD MAR-APR
PY 2011
VL 25
IS 3
BP 210
EP 222
DI 10.1177/1545968310382424
PG 13
WC Clinical Neurology; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Rehabilitation
GA 726NQ
UT WOS:000287730200001
PM 20935339
OA Green Accepted, Green Submitted
DA 2023-08-17
ER

PT J
AU Phatak, VS
   Smith, GE
   Locke, D
   Shandera-Ochsner, A
   Dean, PM
   Ball, C
   Gutierrez, G
   Chandler, MJ
AF Phatak, Vaishali S.
   Smith, Glenn E.
   Locke, Dona
   Shandera-Ochsner, Anne
   Dean, Pamela M.
   Ball, Colleen
   Gutierrez, Gianna
   Chandler, Melanie J.
TI Computerized Cognitive Training (CCT) versus Yoga Impact on 12 Month
   Post Intervention Cognitive Outcome in Individuals with Mild Cognitive
   Impairment
SO BRAIN SCIENCES
LA English
DT Article
DE behavioral interventions; computerized cognitive training (CCT);
   physical exercise; yoga; mild cognitive impairment (MCI); cognitive
   enrichment; clinical trial
ID OLDER-ADULTS; PHYSICAL-EXERCISE; MEMORY; DEMENTIA; METAANALYSIS;
   PERFORMANCE
AB There is currently limited and mixed evidence for the cognitive benefits of Computerized Cognitive Training (CCT) and yoga in persons with Mild Cognitive Impairment (pwMCI). The objective of this study was to investigate the benefit of computerized cognitive training (CCT) vs. physical (yoga) intervention on cognitive abilities. Participants in this study were part of the larger Mayo Clinic's Healthy Action to Benefit Independence and Thinking (HABIT) program comparative effectiveness trial. The HABIT program is designed for pwMCI and their care partner and consists of five behavioral interventions: CCT, Memory Support System-Calendar (MSS-Calendar), wellness education, support groups, and yoga. The subtractive study design randomly withheld one of the interventions for a total of five study arms. Longitudinal mixed-effects regression models were used to investigate the hypothesis that CCT and yoga has a greater positive impact on psychomotor and basic attention abilities at 12 months post-intervention as compared to the other HABIT interventions. Findings showed CCT had a positive impact compared to yoga on the Cogstate psychomotor/attention composite at 12 months post-intervention (ES = 0.54; unadjusted p value = 0.007, adjusted p value = 0.021). The impact of yoga or combining CCT with yoga did not show statistically significant improvement. Continued CCT practice at home showed further benefit on psychomotor/attention at 12 months post-intervention. There was no significant benefit of CCT or yoga on Cogstate learning/working memory composite.
C1 [Phatak, Vaishali S.] Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE 68131 USA.
   [Smith, Glenn E.; Gutierrez, Gianna] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA.
   [Locke, Dona] Mayo Clin Arizona, Dept Psychiat & Psychol, Scottsdale, AZ 85259 USA.
   [Shandera-Ochsner, Anne] Mayo Clin Hlth Syst, Dept Psychiat & Psychol, La Crosse, WI 54601 USA.
   [Dean, Pamela M.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98108 USA.
   [Ball, Colleen] Mayo Clin Florida, Div Clin Trials & Biostat, Jacksonville, FL 32224 USA.
   [Chandler, Melanie J.] Mayo Clin Florida, Dept Psychiat & Psychol, Jacksonville, FL 32224 USA.
C3 University of Nebraska System; University of Nebraska Medical Center;
   State University System of Florida; University of Florida; Mayo Clinic;
   Mayo Clinic Phoenix; University of Washington; University of Washington
   Seattle; Mayo Clinic; Mayo Clinic
RP Phatak, VS (corresponding author), Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE 68131 USA.
EM vaishali.phatak@unmc.edu; glennsmith@phhp.ufl.edu; Locke.Dona@mayo.edu;
   Shandera-Ochsner.Anne@mayo.edu; Pamela.Dean@va.gov;
   Thomas.Colleen@mayo.edu; gianna.gutierrez@ufl.edu;
   Chandler.Melanie@mayo.edu
OI Smith, Glenn/0000-0003-1506-9484
FU PCORI [CER-1306-01897]; NIH [P30AG062677, P30AG066506, P30AG019610]
FX This research was funded by PCORI award CER-1306-01897. The statements
   in this publication are solely the responsibility of the authors and do
   not necessarily represent the views of the Patient-Centered Outcomes
   Research Institute (PCORI), its Board of Governors or Methodology
   Committee. Supplemental support provided by NIH grants P30AG062677,
   P30AG066506 and P30AG019610.
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NR 32
TC 1
Z9 1
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD AUG
PY 2021
VL 11
IS 8
AR 988
DI 10.3390/brainsci11080988
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA UG0VX
UT WOS:000688982300001
PM 34439607
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU D'Antonio, J
   Simon-Pearson, L
   Goldberg, T
   Sneed, JR
   Rushia, S
   Kerner, N
   Andrews, H
   Hellegers, C
   Tolbert, S
   Perea, E
   Petrella, J
   Doraiswamy, M
   Devanand, D
AF D'Antonio, Jessica
   Simon-Pearson, Laura
   Goldberg, Terry
   Sneed, Joel R.
   Rushia, Sara
   Kerner, Nancy
   Andrews, Howard
   Hellegers, Caroline
   Tolbert, Sierra
   Perea, Elena
   Petrella, Jeffrey
   Doraiswamy, Murali
   Devanand, Davangere
TI Cognitive training and neuroplasticity in mild cognitive impairment
   (COG-IT): protocol for a two-site, blinded, randomised, controlled
   treatment trial
SO BMJ OPEN
LA English
DT Article
DE clinical trials; delirium and cognitive disorders; dementia; magnetic
   resonance imaging
ID OLDER-ADULTS; WORKING-MEMORY; DEPRESSION; DEMENTIA; REMEDIATION;
   PLASTICITY; DISEASE; BRAIN
AB Introduction Mild cognitive impairment (MCI) is common in older adults and represents a high-risk group for progression to Alzheimer's disease (AD). Medication trials in MCI have generally failed, but new discoveries with brain plasticity in ageing have led to the study of cognitive training as a potential treatment to improve cognitive abilities. Computerised cognitive training (CCT) involves computerised cognitive exercises that target specific cognitive abilities and neural networks to potentially improve cognitive functioning through neuroplasticity.
   Methods and analysis In a two-site study (New York State Psychiatric Institute/Columbia University Medical Center and Duke University Medical Center), we will randomise 100 patients with MCI (Wechsler Memory Scale-III Logical Memory II score 0-11; Folstein Mini Mental State Examination >= 23) to home-based CCT (suite of exercises: memory, matching, spatial recognition, processing speed) or a home-based active control condition (computerised crossword puzzle training (CPT)) with 12 weeks of intensive training followed by regular booster sessions up to 78 weeks. All patients will receive standard neuropsychological and functional assessments in clinic as well as structural/functional brain MRI scans at study entry and endpoint. We will test if CCT, versus CPT, leads to improved cognitive functioning, transfers to functional ability and tasks of everyday life and impacts hippocampal volume changes and changes in the default mode network of the brain measured by resting-state functional MRI.
   Ethics and dissemination The study will be conducted following ethics approval and written informed consent will be obtained from all subjects. Study results will be disseminated via publication, clinicaltrials.gov, media and conference presentations. This will be the first controlled long-term trial to evaluate the effects of home-based CCT versus computerised CPT on cognitive abilities and functional measures and neural outcomes as determined by MRI indices in patients with MCI. Positive results from trial may support further development of home-based CCT.
   Trial registration number ClinicalTrials.gov identifier (NCT03205709).
C1 [D'Antonio, Jessica; Simon-Pearson, Laura; Goldberg, Terry; Sneed, Joel R.; Devanand, Davangere] New York State Psychiat Inst & Hosp, Div Geriatr Psychiat, New York, NY 10032 USA.
   [Goldberg, Terry; Kerner, Nancy; Devanand, Davangere] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY 10027 USA.
   [Sneed, Joel R.; Rushia, Sara] CUNY, Queens Coll, Dept Psychol, Flushing, NY USA.
   [Rushia, Sara] CUNY, Grad Ctr, Dept Psychol, New York, NY USA.
   [Andrews, Howard] Columbia Univ, Med Ctr, Dept Biostat, Mailman Sch Publ Hlth, New York, NY USA.
   [Hellegers, Caroline; Tolbert, Sierra; Perea, Elena; Doraiswamy, Murali] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA.
   [Petrella, Jeffrey] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA.
C3 New York State Psychiatry Institute; Columbia University; City
   University of New York (CUNY) System; Queens College NY (CUNY); City
   University of New York (CUNY) System; Columbia University; Duke
   University; Duke University
RP Devanand, D (corresponding author), New York State Psychiat Inst & Hosp, Div Geriatr Psychiat, New York, NY 10032 USA.; Devanand, D (corresponding author), Columbia Univ, Dept Psychiat, Med Ctr, New York, NY 10027 USA.
EM dpd3@cumc.columbia.edu
OI Pence, Sierra/0000-0002-1073-3473
FU National Institute on Aging, National Institutes of Health
   [1R01AG052440-01A1]
FX This work is supported by National Institute on Aging, National
   Institutes of Health, grant number 1R01AG052440-01A1. We thank Lumos
   Labs for providing the gaming platform at no cost; however, they will
   not have any involvement in the final design, conduct or analyses of the
   study.
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NR 38
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Z9 18
U1 3
U2 24
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD AUG
PY 2019
VL 9
IS 8
DI 10.1136/bmjopen-2018-028536
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JV7JK
UT WOS:000502537200178
PM 31471436
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Kounti, F
   Bakoglidou, E
   Agogiatou, C
   Lombardo, NBE
   Serper, LL
   Tsolaki, M
AF Kounti, Fotini
   Bakoglidou, Evaggelia
   Agogiatou, Christina
   Lombardo, Nancy B. Emerson
   Serper, Lynn Lazarus
   Tsolaki, Magda
TI RHEA, a Nonpharmacological Cognitive Training Intervention in Patients
   With Mild Cognitive Impairment A Pilot Study
SO TOPICS IN GERIATRIC REHABILITATION
LA English
DT Article
DE cognition; cognitive motion therapy; cognitive training; kinetic
   exercises; MCI; neural plasticity; nonpharmacological intervention; RHEA
ID WORKING-MEMORY CAPACITY; ALZHEIMERS-DISEASE; CORTICAL PLASTICITY;
   EXECUTIVE ATTENTION; OLDER-ADULTS; DEMENTIA; SCALE; MCI; REHABILITATION;
   RELIABILITY
AB Objective: This study aimed to examine the effectiveness of RHEA, a cognitive training through kinetic exercises, on patients with mild cognitive impairment.
   Subjects and Method: Participants, completing study, were 58 mild cognitive impairment patients with MMSE = 27.69, assigned to 2 groups of 29 each (experimental, 20-weekly RHEA sessions, and no-therapy control), matched for age, gender, education, cholinesterase inhibitors, cognitive abilities. Neuropsychological assessments were performed at baseline and after 5 months.
   Results: Between groups difference to the benefit of the experimental group were demonstrated in attention (P = .002), language (P = .015), visual-spatial abilities (P = .013), MMSE (P = .047), and daily function (P = .009). Experimental participants improved cognitive and functional performances while control participants remained stable.
C1 [Kounti, Fotini; Bakoglidou, Evaggelia; Agogiatou, Christina; Tsolaki, Magda] Hellen Greek Alzheimer Assoc, Thessaloniki, Greece.
   [Tsolaki, Magda] Aristotle Univ Thessaloniki, Sch Med, Dept Neurol 3, Thessaloniki, Macedonia, Greece.
   [Kounti, Fotini; Bakoglidou, Evaggelia; Agogiatou, Christina; Tsolaki, Magda] Alzheimer Assoc Kalamaria, Thessaloniki, Greece.
   [Serper, Lynn Lazarus] Brain Enhancement Serv, Waltham, MA USA.
   [Lombardo, Nancy B. Emerson] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.
C3 Aristotle University of Thessaloniki; Boston University
RP Tsolaki, M (corresponding author), Aristotle Univ Thessaloniki, Sch Med, Dept Neurol 3, Petrou Sindika 13, Thessaloniki, Macedonia, Greece.
EM tsolakim1@ath.forthnet.gr
OI Tsolaki, Magda/0000-0002-2072-8010
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NR 74
TC 20
Z9 21
U1 1
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0882-7524
EI 1550-2414
J9 TOP GERIATR REHABIL
JI Top. Geriatr. Rehabil.
PD OCT-DEC
PY 2011
VL 27
IS 4
BP 289
EP 300
DI 10.1097/TGR.0b013e31821e59a9
PG 12
WC Gerontology; Rehabilitation
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Rehabilitation
GA 852DZ
UT WOS:000297330400005
DA 2023-08-17
ER

PT J
AU Lim, MHX
   Liu, KPY
   Cheung, GSF
   Kuo, MCC
   Li, RJ
   Tong, CY
AF Lim, Michelle H. X.
   Liu, Karen P. Y.
   Cheung, Gloria S. F.
   Kuo, Michael C. C.
   Li, Ruijie
   Tong, Choy-Ying
TI Effectiveness of a Multifaceted Cognitive Training Programme for People
   with Mild Cognitive Impairment: A One-Group Pre- and Posttest Design
SO HONG KONG JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
DE cognitive training; community-based participatory research; geriatrics;
   memory
ID ALZHEIMERS-DISEASE; CONSORTIUM; EDUCATION; ESTABLISH; REGISTRY; PROFILE;
   AGE
AB Objectives: The effectiveness of a cognitive training programme in enhancing the functional abilities of elderly persons with mild cognitive impairments was tested in an integrated home and institutional training programme focused on performing daily tasks.
   Methods: Twenty elderly participants were taught cognitive stimulation and memory encoding strategies for 10 weeks by an occupational therapist, or by nonprofessionals and community caregivers. The programme consisted of attention and memory stimulation, association-based and imagery-based strategies. Functional assessment (Chinese version of the disability assessment for dementia instrument and the instrumental activities of daily living scale) and neuropsychological tests (digit span forward test, word list memory subtest of the neuropsychological test battery developed by the Consortium to Establish a Registry for Alzheimer's Disease, Cognistat) were administered before and after the programme.
   Results: After the 10-week programme the participants showed significant improvements in average attention and memory. The participants showed improved memory (word list memory: p <= .001) and other cognitive function as measured by the naming (p <= .001), construction (p <= .001), memory (p <= .001) and similarities (p <= .001) subtests of the Cognistat.
   Conclusion: These results provide initial evidence supporting the use of daily tasks as the context in teaching cognitive stimulation and memory encoding strategies to mildly impaired elderly people. Copyright (C) 2012, Elsevier (Singapore) Pte. Ltd. All rights reserved.
C1 [Liu, Karen P. Y.] Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 2751, Australia.
   [Lim, Michelle H. X.] Singapore Gen Hosp, Dept Occupat Therapy, Singapore 0316, Singapore.
   [Cheung, Gloria S. F.; Tong, Choy-Ying] Christian Family Serv Ctr, Hong Kong, Hong Kong, Peoples R China.
   [Liu, Karen P. Y.; Kuo, Michael C. C.] Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Hong Kong, Peoples R China.
   [Li, Ruijie] Natl Healthcare Grp, Singapore, Singapore.
C3 Western Sydney University; Singapore General Hospital; Hong Kong
   Polytechnic University
RP Liu, KPY (corresponding author), Univ Western Sydney, Sch Sci & Hlth, Locked Bag 1797, Penrith, NSW 2751, Australia.
EM Karen.Liu@uws.edu.au
RI Liu, Karen/ABG-1646-2020
OI Liu, Karen/0000-0001-7397-5149; Li, Ruijie/0000-0001-8219-1733; Kuo,
   Michael/0000-0002-0802-1207
FU Research Grants Council of the Hong Kong Special Administrative Region,
   China [PolyU 5620/07 M]
FX The work described in this paper was supported by a grant from the
   Research Grants Council of the Hong Kong Special Administrative Region,
   China (Project No. PolyU 5620/07 M) awarded to K.P.Y. Liu, The Hong Kong
   Polytechnic University.
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NR 20
TC 10
Z9 11
U1 0
U2 31
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1569-1861
EI 1876-4398
J9 HONG KONG J OCCUP TH
JI Hong Kong J. Occup. Ther.
PD JUN
PY 2012
VL 22
IS 1
BP 3
EP 8
DI 10.1016/j.hkjot.2012.04.002
PG 6
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA 006XU
UT WOS:000308853900002
OA gold
DA 2023-08-17
ER

PT J
AU Zhang, HF
   Wang, ZJ
   Wang, J
   Lyu, XZ
   Wang, X
   Liu, Y
   Zeng, XZ
   Yuan, HS
   Wang, HL
   Yu, X
AF Zhang, Haifeng
   Wang, Zhijiang
   Wang, Jing
   Lyu, Xiaozhen
   Wang, Xiao
   Liu, Ying
   Zeng, Xiangzhu
   Yuan, Huishu
   Wang, Huali
   Yu, Xin
TI Computerized multi-domain cognitive training reduces brain atrophy in
   patients with amnestic mild cognitive impairment
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID WORKING-MEMORY; OLDER-ADULTS; ALZHEIMERS-DISEASE; NORMATIVE DATA;
   NETWORK HUBS; INTERVENTION; CONNECTIVITY; PLASTICITY; PROGRESSION;
   DEMENTIA
AB The present study aimed to explore the effect of computerized multi-domain cognitive training (MDCT) on brain gray matter volume and neuropsychological performance in patients with amnestic mild cognitive impairment (amnestic MCI). Twenty-one patients with amnestic MCI participated in a computerized MDCT program. The program targeted a broad set of cognitive domains via programs focused on reasoning, memory, visuospatial, language, calculation, and attention. Seventeen Participants completed the intervention and all completed a battery of neuropsychological tests to evaluate cognitive function while 12 out of 17 underwent 3 T MRI scanning before and after the intervention to measure gray matter (GM) volume. We examined correlations between the changes in neuropsychological scores and GM volumes across participants after the intervention. After training, we observed significant increases in GM volume in the right angular gyrus (AG) and other parietal subareas near the intraparietal sulcus (p < 0.05, FWE-corrected, 10000 permutations). However, we found no significant changes in neuropsychological test scores (p > 0.05). A correlation analysis revealed positive correlations between the changes in GM volume in the right AG and scores in the immediate recall component of the Hopkins Verbal Learning Test-Revised (HVLT-R) (r=0.64, p=0.024) and the Brief Visuospatial Memory Test-Revised (BVMT-R) (r=0.67, p=0.016). Our findings indicate that a computerized MDCT program may protect patients with amnestic MCI against brain GM volume loss and has potential in preserving general cognition. Thus, our non-pharmacological intervention may slow the rate of disease progression.
C1 [Zhang, Haifeng; Wang, Zhijiang; Wang, Jing; Lyu, Xiaozhen; Wang, Xiao; Wang, Huali; Yu, Xin] Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China.
   [Zhang, Haifeng; Wang, Zhijiang; Wang, Jing; Lyu, Xiaozhen; Wang, Xiao; Wang, Huali; Yu, Xin] Peking Univ, Minist Hlth, Nat Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China.
   [Zhang, Haifeng; Wang, Zhijiang; Wang, Jing; Lyu, Xiaozhen; Wang, Xiao; Wang, Huali; Yu, Xin] Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China.
   [Zhang, Haifeng; Wang, Zhijiang; Wang, Jing; Lyu, Xiaozhen; Wang, Xiao; Wang, Huali; Yu, Xin] Beijing Municipal Key Lab Translat Res Diag & Tre, Beijing 100191, Peoples R China.
   [Liu, Ying; Zeng, Xiangzhu; Yuan, Huishu] Peking Univ, Hosp 3, Beijing 100191, Peoples R China.
C3 Peking University; Peking University; Peking University; Peking
   University
RP Wang, ZJ; Wang, HL (corresponding author), Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China.; Wang, ZJ; Wang, HL (corresponding author), Peking Univ, Minist Hlth, Nat Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China.; Wang, ZJ; Wang, HL (corresponding author), Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China.
EM wang.zj.ross@gmail.com; huali_wang@bjmu.edu.cn
RI Wang, Huali/S-9848-2018; Yu, Xinchi/ABC-7745-2020
OI Yu, Xinchi/0000-0002-6165-7909
FU Beijing Municipal Science & Technology Commission [Z161100000516001,
   D171100008217007]; National Natural Science Foundation of China
   [81701777, 81500918]; China Scholarship Council (CSC) [201706010329]
FX We acknowledge Beijing Neowave Technology Co., Ltd, who co-developed the
   training system, and the funding provided by Beijing Municipal Science &
   Technology Commission (No. Z161100000516001, D171100008217007) and
   National Natural Science Foundation of China (No. 81701777 and No.
   81500918). H.Z. thanks the China Scholarship Council (CSC) for the
   financial support (No. 201706010329) to be a visiting PhD student at
   University College London, UK. We thank Sydney Koke, MFA, from Edanz
   Group (www.edanzediting.com/ac) for editing a draft of this manuscript.
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NR 59
TC 17
Z9 18
U1 1
U2 25
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JAN 31
PY 2019
VL 9
AR 48
DI 10.1038/s41398-019-0385-x
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HM9VN
UT WOS:000459833200002
PM 30705261
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Barnes, D
   Yaffe, K
   Belfor, N
   Reed, B
   Jagust, W
   DeCarli, C
   Kramer, J
AF Barnes, D
   Yaffe, K
   Belfor, N
   Reed, B
   Jagust, W
   DeCarli, C
   Kramer, J
TI Computer-based cognitive training for mild cognitive impairment: Results
   from a pilot randomized controlled trial
SO NEUROLOGY
LA English
DT Meeting Abstract
CT 58th Annual Meeting of the American-Academy-of-Neurology
CY APR 01-08, 2006
CL San Diego, CA
SP Amer Acad Neruol
RI DeCarli, Charles/B-5541-2009
NR 0
TC 5
Z9 5
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD MAR 14
PY 2006
VL 66
IS 5
SU 2
BP A249
EP A249
PG 1
WC Clinical Neurology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 022PM
UT WOS:000236068103036
DA 2023-08-17
ER

PT J
AU Motter, JN
   Rushia, SN
   Qian, M
   Ndouli, C
   Nwosu, A
   Petrella, JR
   Doraiswamy, PM
   Goldberg, TE
   Devanand, DP
AF Motter, Jeffrey N.
   Rushia, S. N.
   Qian, M.
   Ndouli, C.
   Nwosu, A.
   Petrella, J. R.
   Doraiswamy, P. M.
   Goldberg, T. E.
   Devanand, D. P.
TI Expectancy Does Not Predict 18-month Treatment Outcomes with Cognitive
   Training in Mild Cognitive Impairment
SO JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
LA English
DT Article; Early Access
DE Expectancy; age; mild cognitive impairment; computerized cognitive
   training; crossword puzzles
ID SURFACE-BASED ANALYSIS; SEGMENTATION; MRI
AB BackgroundComputerized cognitive training (CCT) has emerged as a potential treatment option for mild cognitive impairment (MCI). It remains unclear whether CCT's effect is driven in part by expectancy of improvement.ObjectivesThis study aimed to determine factors associated with therapeutic expectancy and the influence of therapeutic expectancy on treatment effects in a randomized clinical trial of CCT versus crossword puzzle training (CPT) for older adults with MCI.DesignRandomized clinical trial of CCT vs CPT with 78-week follow-up.SettingTwo-site study - New York State Psychiatric Institute and Duke University Medical Center.Participants107 patients with MCI.Intervention12 weeks of intensive training with CCT or CPT with follow-up booster training over 78 weeks.MeasurementsPatients rated their expectancies for CCT and CPT prior to randomization.ResultsPatients reported greater expectancy for CCT than CPT. Lower patient expectancy was associated with lower global cognition at baseline and older age. Expectancy did not differ by sex or race. There was no association between expectancy and measures of everyday functioning, hippocampus volume, or apolipoprotein E genotype. Expectancy was not associated with change in measures of global cognition, everyday functioning, and hippocampus volume from baseline to week 78, nor did expectancy interact with treatment condition.ConclusionsWhile greater cognitive impairment and increased age was associated with low expectancy of improvement, expectancy was not associated with the likelihood of response to treatment with CPT or CCT.
C1 [Motter, Jeffrey N.; Ndouli, C.; Goldberg, T. E.; Devanand, D. P.] Columbia Univ, Dept Psychiat, Irving Med Ctr, New York, NY USA.
   [Motter, Jeffrey N.; Ndouli, C.; Goldberg, T. E.; Devanand, D. P.] New York State Psychiat Inst & Hosp, Div Geriatr Psychiat, New York, NY USA.
   [Rushia, S. N.] Univ Massachusetts, Chan Med Sch, Worcester, MA USA.
   [Qian, M.] Columbia Univ, Dept Biostat, Mailman Sch Publ Hlth, Irving Med Ctr, New York, NY USA.
   [Nwosu, A.; Petrella, J. R.; Doraiswamy, P. M.] Duke Univ, Sch Med, Durham, NC USA.
   [Nwosu, A.; Petrella, J. R.; Doraiswamy, P. M.] Duke Inst Brain Sci, Durham, NC USA.
   [Motter, Jeffrey N.] Columbia Univ, Dept Psychiat, Irving Med Ctr, 1051 Riverside Dr, New York, NY 10032 USA.
C3 Columbia University; NewYork-Presbyterian Hospital; New York State
   Psychiatry Institute; University of Massachusetts System; University of
   Massachusetts Worcester; Columbia University; NewYork-Presbyterian
   Hospital; Duke University; Columbia University; NewYork-Presbyterian
   Hospital
RP Motter, JN (corresponding author), Columbia Univ, Dept Psychiat, Irving Med Ctr, 1051 Riverside Dr, New York, NY 10032 USA.
EM jm5077@cumc.columbia.edu
FU National Institute on Aging [1R01AG052440-01A1]; National Institute of
   Mental Health [2T32MH020004-21]
FX This work is supported by National Institute on Aging grant number
   1R01AG052440-01A1 and National Institute of Mental Health grant number
   <EM><STRONG> </STRONG></EM>2T32MH020004-21. Lumos Labs provided the
   gaming platform at no cost. Lumos Labs had no role in the design and
   conduct of the study; in the collection, analysis, and interpretation of
   data; in the preparation of the manuscript; or in the review or approval
   of the manuscript.
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NR 29
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 2274-5807
EI 2426-0266
J9 JPAD-J PREV ALZHEIM
JI JPAD-J. Prev. Alzheimers Dis.
PD 2023 MAY 26
PY 2023
DI 10.14283/jpad.2023.62
EA MAY 2023
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA H2YT5
UT WOS:000994681500001
DA 2023-08-17
ER

PT J
AU Palestra, G
   Pino, O
AF Palestra, Giuseppe
   Pino, Olimpia
TI Detecting emotions during a memory training assisted by a social robot
   for individuals with Mild Cognitive Impairment (MCI)
SO MULTIMEDIA TOOLS AND APPLICATIONS
LA English
DT Article
DE Facial expression recognition; Social robot; Memory training; Mild
   Cognitive Impairment
ID TELEPRESENCE; DEMENTIA
AB The attention towards robot-assisted therapies (RAT) had grown steadily in recent years particularly for patients with dementia. However, rehabilitation practice using humanoid robots for individuals with Mild Cognitive Impairment (MCI) is still a novel method for which the adherence mechanisms, indications and outcomes remain unclear. An effective computing represents a wide range of technological opportunities towards the employment of emotions to improve human-computer interaction. Therefore, the present study addresses the effectiveness of a system in automatically decode facial expression from video-recorded sessions of a robot-assisted memory training lasted two months involving twenty-one participants. We explored the robot's potential to engage participants in the intervention and its effects on their emotional state. Our analysis revealed that the system is able to recognize facial expressions from robot-assisted group therapy sessions handling partially occluded faces. Results indicated reliable facial expressiveness recognition for the proposed software adding new evidence base to factors involved in Human-Robot Interaction (HRI). The use of a humanoid robot as a mediating tool appeared to promote the engagement of participants in the training program. Our findings showed positive emotional responses for females. Tasks affects differentially affective involvement. Further studies should investigate the training components and robot responsiveness.
C1 [Palestra, Giuseppe] HERO Srl, Res Dept, Bari, Italy.
   [Pino, Olimpia] Univ Parma, Dept Med & Surg, Parma, Italy.
C3 University of Parma
RP Pino, O (corresponding author), Univ Parma, Dept Med & Surg, Parma, Italy.
EM giuseppepalestra@gmail.com; olimpia.pino@unipr.it
RI Pino, Olimpia/AFY-8034-2022; Palestra, Giuseppe/HLW-6307-2023
OI Pino, Olimpia/0000-0003-3035-8401; PALESTRA,
   GIUSEPPE/0000-0002-0159-2672
FU Universita degli Studi di Parma within the CRUI-CARE Agreement
FX Open access funding provided by Universita degli Studi di Parma within
   the CRUI-CARE Agreement.
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NR 50
TC 6
Z9 6
U1 1
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1380-7501
EI 1573-7721
J9 MULTIMED TOOLS APPL
JI Multimed. Tools Appl.
PD DEC
PY 2020
VL 79
IS 47-48
BP 35829
EP 35844
DI 10.1007/s11042-020-10092-4
EA NOV 2020
PG 16
WC Computer Science, Information Systems; Computer Science, Software
   Engineering; Computer Science, Theory & Methods; Engineering, Electrical
   & Electronic
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Computer Science; Engineering
GA PA9WZ
UT WOS:000587107900001
OA hybrid
DA 2023-08-17
ER

PT J
AU Barnes, DE
   Yaffe, K
   Belfor, N
   Jagust, WJ
   DeCarli, C
   Reed, BR
   Kramer, JH
AF Barnes, Deborah E.
   Yaffe, Kristine
   Belfor, Nataliya
   Jagust, William J.
   DeCarli, Charles
   Reed, Bruce R.
   Kramer, Joel H.
TI Computer-based Cognitive Training for Mild Cognitive Impairment Results
   from a Pilot Randomized, Controlled Trial
SO ALZHEIMER DISEASE & ASSOCIATED DISORDERS
LA English
DT Article; Proceedings Paper
CT 10th International Conference on Alzheimers Disease and Related
   Disorders
CY JUL 15-16, 2006-2007
CL Madrid, SPAIN
DE human; aged; cognition; cognitive rehabilitation; memory;
   neuropsychologic tests; randomized controlled trial; mild cognitive
   impairment
ID HEALTHY OLDER-ADULTS; ALZHEIMERS-DISEASE; MEMORY ENHANCEMENT;
   REHABILITATION; STIMULATION; INTERVENTION; DEMENTIA; EFFICACY; PROGRAM;
   PEOPLE
AB We performed a pilot randomized, controlled trial of intensive, computer-based cognitive training in 47 subjects with mild cognitive impairment. The intervention group performed exercises specifically designed to improve auditory processing speed and accuracy for 100 min/d, 5 d/wk for 6 weeks; the control group performed more passive computer activities (reading, listening, visuospatial game) for similar amounts of time. Subjects had a mean age of 74 years and 60% were men; 77% successfully completed training. On our primary outcome, Repeatable Battery for Assessment of Neuropsychological Status total scores improved 0.36 standard deviations (SD) in the intervention group (P = 0.097) compared with 0.03 SD in the control group (P = 0.88) for a nonsignificant difference between the groups of 0.33 SD (P = 0.26). On 12 secondary outcome measures, most differences between the groups were not statistically significant. However, we observed a pattern in which effect sizes for verbal learning and memory measures tended to favor the intervention group whereas effect sizes for language and visuospatial function measures tended to favor the control group, which raises the possibility that these training programs may have domain-specific effects. We conclude that intensive, computer-based mental activity is feasible in subjects with mild cognitive impairment and that larger trials are warranted.
C1 [Barnes, Deborah E.; Yaffe, Kristine; Belfor, Nataliya] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94121 USA.
   [Yaffe, Kristine; Kramer, Joel H.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94121 USA.
   [Barnes, Deborah E.; Yaffe, Kristine] San Francisco VA Med Ctr, Mental Hlth Res Serv, San Francisco, CA USA.
   [DeCarli, Charles; Reed, Bruce R.] Univ Calif Davis, Dept Neurol, Davis, CA 95616 USA.
   [Jagust, William J.] Univ Calif Berkeley, Dept Neurosci, Berkeley, CA 94720 USA.
   [Jagust, William J.] Univ Calif Berkeley, Dept Publ Hlth, Berkeley, CA 94720 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   San Francisco VA Medical Center; University of California System;
   University of California Davis; University of California System;
   University of California Berkeley; University of California System;
   University of California Berkeley
RP Barnes, DE (corresponding author), Univ Calif San Francisco, Dept Psychiat, 4150 Clement St 151R, San Francisco, CA 94121 USA.
EM Deborah.Barnes@ucsf.edu
RI Jagust, William/ABE-6426-2020; DeCarli, Charles/B-5541-2009
FU NIA NIH HHS [K01 AG024069, P30 AG010129, P30 AG010129-17, K01 AG 024069,
   K01 AG024069-04, P30 AG010129-18] Funding Source: Medline
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NR 37
TC 194
Z9 205
U1 2
U2 82
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0893-0341
J9 ALZ DIS ASSOC DIS
JI Alzheimer Dis. Assoc. Dis.
PD JUL-SEP
PY 2009
VL 23
IS 3
BP 205
EP 210
DI 10.1097/WAD.0b013e31819c6137
PG 6
WC Clinical Neurology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Pathology
GA 495QO
UT WOS:000269909300005
PM 19812460
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Stypulkowski, K
   Anquillare, E
   Twamley, EW
   Thayer, RE
AF Stypulkowski, Katie
   Anquillare, Elizabeth
   Twamley, Elizabeth W.
   Thayer, Rachel E.
TI Feasibility of a Telehealth Compensatory Cognitive Training Program for
   Older Adults with Mild Cognitive Impairment
SO CLINICAL GERONTOLOGIST
LA English
DT Article; Early Access
DE Cognitive training; mild cognitive impairment; older adults; telehealth
ID REHABILITATION; DEMENTIA; VETERANS; COGSMART
AB ObjectivesOlder adults experiencing mild cognitive impairment (MCI) may benefit from compensatory cognitive training (CCT). This study investigated the feasibility of telehealth CCT among older adults with MCI.MethodsAdults age 55+ with MCI (n = 28) and a care partner (n = 18) participated in telehealth CCT. Participants rated sessions' technological interference on an adapted 0-100 session rating scale (higher scores=less interference). Clinicians provided ratings and qualitative feedback on types of interference experienced. Feasibility was assessed by enrollment and completion rates, and through ratings and feedback.Results6% of contacts declined participation due to telehealth delivery. 24 of 28 participants completed the program, with no dropouts due to telehealth. Participants (M = 81.32, SD = 25.61) and clinicians (M = 76.24, SD = 33.37) rated technological interference as infrequent. Clinicians indicated most interference did not impact sessions, though 4% required rescheduling due to interference.ConclusionsTelehealth delivery was not a barrier to recruitment, enrollment, or completion of CCT. Technological problems were mostly minor. Telehealth CCT could support access to and intervention among older adults with MCI.Clinical ImplicationsTelehealth CCT for older adults with MCI was feasible, with mild issues not impacting session completion. Clinicians should be prepared to offer support as technological issues arise, or have dedicated technological support services.
C1 [Stypulkowski, Katie; Anquillare, Elizabeth; Thayer, Rachel E.] Univ Colorado Colorado Springs, Psychol Dept, Colorado Springs, CO USA.
   [Twamley, Elizabeth W.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA.
   [Twamley, Elizabeth W.] VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
   [Stypulkowski, Katie] Cleveland Clin Lou Ruvo Ctr Brain Hlth, 888 W Bonneville Ave, Las Vegas, NV 89106 USA.
C3 University of Colorado System; University of Colorado at Colorado
   Springs; University of California System; University of California San
   Diego; US Department of Veterans Affairs; Veterans Health Administration
   (VHA); VA San Diego Healthcare System; Cleveland Clinic Foundation
RP Stypulkowski, K (corresponding author), Cleveland Clin Lou Ruvo Ctr Brain Hlth, 888 W Bonneville Ave, Las Vegas, NV 89106 USA.
EM stypulk@ccf.org
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NR 30
TC 0
Z9 0
U1 1
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-7115
EI 1545-2301
J9 CLIN GERONTOLOGIST
JI Clin. Gerontol.
PD 2023 MAY 18
PY 2023
DI 10.1080/07317115.2023.2213694
EA MAY 2023
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA G4TV9
UT WOS:000989107100001
PM 37195804
DA 2023-08-17
ER

PT J
AU Das, N
   Spence, JS
   Aslan, S
   Vanneste, S
   Mudar, R
   Rackley, A
   Quiceno, M
   Chapman, SB
AF Das, Namrafa
   Spence, Jeffrey S.
   Aslan, Sina
   Vanneste, Sven
   Mudar, Raksha
   Rackley, Audette
   Quiceno, Mary
   Chapman, Sandra Bond
TI Cognitive Training and Transcranial Direct Current Stimulation in Mild
   Cognitive Impairment: A Randomized Pilot Trial
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE mild cognitive impairment; Alzheimer's disease; transcranial direct
   current stimulation; cerebral blood flow; fMRI; cognitive training;
   strategic memory advanced reasoning training; brain modulation
ID TRAUMATIC BRAIN-INJURY; DISEASE; MEMORY; INHIBITION; ACTIVATION;
   DEMENTIA; RISK; TDCS
AB Background: Transcranial direct current stimulation (tDCS), a non-invasive stimulation, represents a potential intervention to enhance cognition across clinical populations including Alzheimer's disease and mild cognitive impairment (MCI). This randomized clinical trial in MCI investigated the effects of anodal tDCS (a-tDCS) delivered to left inferior frontal gyrus (IFG) combined with gist-reasoning training (SMART) versus sham tDCS (s-tDCS) plus SMART on measures of cognitive and neural changes in resting cerebral blood flow (rCBF). We were also interested in SMART effects on cognitive performance regardless of the tDCS group.
   Methods: Twenty-two MCI participants, who completed the baseline cognitive assessment (T1), were randomized into one of two groups: a-tDCS + SMART and s-tDCS + SMART. Of which, 20 participants completed resting pCASL MRI scan to measure rCBF. Eight SMART sessions were administered over 4 weeks with a-tDCS or s-tDCS stimulation for 20 min before each session. Participants were assessed immediately (T2) and 3-months after training (T3).
   Results: Significant group x time interactions showed cognitive gains at T2 in executive function (EF) measure of inhibition [DKEFS- Color word (p = 0.047)], innovation [TOSL (p = 0.01)] and on episodic memory [TOSL (p = 0.048)] in s-tDCS + SMART but not in a-tDCS + SMART group. Nonetheless, the gains did not persist for 3 months (T3) after the training. A voxel-based analysis showed significant increase in regional rCBF in the right middle frontal cortex (MFC) (cluster-wise p = 0.05, k = 1,168 mm(3)) in a-tDCS + SMART compared to s-tDCS + SMART. No significant relationship was observed between the increased CBF with cognition. Irrespective of group, the combined MCI showed gains at T2 in EF of conceptual reasoning [DKEFS card sort (p = 0.033)] and category fluency [COWAT (p = 0.055)], along with gains at T3 in EF of verbal fluency [COWAT (p = 0.009)].
   Conclusion: One intriguing finding is a-tDCS to left IFG plus SMART increased blood flow to right MFC, however, the stimulation seemingly blocked cognitive benefits of SMART on EF (inhibition and innovation) and episodic memory compared to s-tDCS + SMART group. Although the sample size is small, this paper contributes to growing evidence that cognitive training provides a way to significantly enhance cognitive performance in adults showing memory loss, where the role of a-tDCS in augmenting these effects need further study.
C1 [Das, Namrafa; Spence, Jeffrey S.; Aslan, Sina; Vanneste, Sven; Rackley, Audette; Chapman, Sandra Bond] Univ Texas Dallas, Ctr BrainHlth, Dallas, TX 75080 USA.
   [Aslan, Sina] Adv MRI LLC, Frisco, TX USA.
   [Mudar, Raksha] Univ Illinois, Dept Speech & Hearing Sci, Champaign, IL USA.
   [Quiceno, Mary] Univ North Texas, Hlth Sci Ctr, Ft Worth, TX USA.
   [Quiceno, Mary] Univ North Texas, Dept Internal Med & Geriatr, Ft Worth, TX USA.
   [Quiceno, Mary] Univ North Texas, TCU UNTHSC, Sch Med, Dept Med Educ, Ft Worth, TX USA.
C3 University of Texas System; University of Texas Dallas; University of
   Illinois System; University of Illinois Urbana-Champaign; University of
   North Texas System; University of North Texas Denton; University of
   North Texas System; University of North Texas Denton; University of
   North Texas System; University of North Texas Denton
RP Chapman, SB (corresponding author), Univ Texas Dallas, Ctr BrainHlth, Dallas, TX 75080 USA.
EM schapman@utdallas.edu
OI Vanneste, Sven/0000-0003-1513-5752
FU BvB Dallas; Sammons Enterprises; Barbara Wallace and Kelly King
   Charitable Foundation Trust; Dallas Foundation; Golden Rule Family
   Foundation
FX This research project was supported by BvB Dallas, Sammons Enterprises,
   Barbara Wallace and Kelly King Charitable Foundation Trust, the AWARE
   fund of the Dallas Foundation, and the Golden Rule Family Foundation.
   ClinicalTrials.gov ID: NCT02588209.
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NR 70
TC 28
Z9 30
U1 2
U2 32
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD APR 12
PY 2019
VL 13
AR 307
DI 10.3389/fnins.2019.00307
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HT3GB
UT WOS:000464451200001
PM 31031581
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Flak, MM
   Hol, HR
   Hernes, SS
   Chang, LD
   Engvig, A
   Bjuland, KJ
   Pripp, A
   Madsen, BO
   Knapskog, AB
   Ulstein, I
   Lona, T
   Skranes, J
   Lohaugen, GCC
AF Flak, Marianne M.
   Hol, Haakon R.
   Hernes, Susanne S.
   Chang, Linda
   Engvig, Andreas
   Bjuland, Knut Jorgen
   Pripp, Are
   Madsen, Bengt-Ove
   Knapskog, Anne-Brita
   Ulstein, Ingun
   Lona, Trine
   Skranes, Jon
   Lohaugen, Gro C. C.
TI Adaptive Computerized Working Memory Training in Patients With Mild
   Cognitive Impairment. A Randomized Double-Blind Active Controlled Trial
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE computerized cognitive training; working memory; mild cognitive
   impairment (MCI); neuropsychological outcomes; randomized controlled
   trial (RCT)
ID OLDER-ADULTS; DEMENTIA; PLASTICITY; PROGRAM; REHABILITATION;
   INTERVENTIONS; IMPROVEMENT; EFFICACY; DISEASE; MCI
AB Objective: We investigated if a 5-week computerized adaptive working memory training program (CogmedR (R)) of 20 to 25 sessions would be effective in improving the working memory capacity and other neuropsychological functions compared to a non-adaptive working memory training program (active-controlled) in adult patients with mild cognitive impairment (MCI).
   Methods: This randomized double-blinded active control trial included 68 individuals aged 43 to 88 years, 45 men and 23 women, who were diagnosed with MCI at four Memory clinics. The study sample was randomized by block randomization to either adaptive or non-adaptive computerized working memory training. All participants completed the training, and were assessed with a comprehensive neuropsychological test battery before the intervention, and at 1 and 4 months after training.
   Results: Compared to the non-adaptive training group, the adaptive training group did not show significantly greater improvement on the main outcome of working memory performance at 1 and 4 months after training.
   Conclusion: No difference were found between the two types of training on the primary outcome of working memory, or on secondary outcomes of cognitive function domains, in this sample of MCI patients. Hence, the hypothesis that the adaptive training program would lead to greater improvements compared to the non-adaptive training program was not supported. Within group analyses was not performed due to the stringent RCT design.
C1 [Flak, Marianne M.; Skranes, Jon] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [Flak, Marianne M.; Skranes, Jon; Lohaugen, Gro C. C.] Sorlandet Hosp HF, Dept Pediat, Arendal, Norway.
   [Hol, Haakon R.] Sorlandet Hosp HF, Dept Radiol, Arendal, Norway.
   [Hol, Haakon R.; Hernes, Susanne S.] Univ Bergen, Dept Clin Sci, Bergen, Norway.
   [Hernes, Susanne S.; Madsen, Bengt-Ove] Sorlandet Hosp, Dept Med, Memory Clin Geriatr Unit, Arendal, Norway.
   [Chang, Linda] Univ Maryland, Sch Med, Dept Diagnost Radiol & Nucl Med, Baltimore, MD 21201 USA.
   [Chang, Linda] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA.
   [Chang, Linda] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA.
   [Engvig, Andreas] Diakonhjemmet Hosp, Dept Med, Oslo, Norway.
   [Bjuland, Knut Jorgen] Sorlandet Hosp, Dept Res, Arendal, Norway.
   [Pripp, Are] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol Res Support Serv, Oslo, Norway.
   [Knapskog, Anne-Brita; Ulstein, Ingun] Oslo Univ Hosp, Memory Clin, Dept Geriatr Med, Oslo, Norway.
   [Lona, Trine] Hosp Telemark, Dept Psychiat, Age Psychiat, Skien, Norway.
C3 Norwegian University of Science & Technology (NTNU); University of
   Bergen; University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; Diakonhjemmet Hospital; University of Oslo;
   University of Oslo; Telemark Hospital Trust
RP Flak, MM (corresponding author), Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.; Flak, MM (corresponding author), Sorlandet Hosp HF, Dept Pediat, Arendal, Norway.
EM marianne.moretro.flak@sshf.no
RI Engvig, Andreas/HMV-2110-2023; Hernes, Susanne/H-7653-2019; Hol, Haakon
   Ramsland/AAC-7388-2022; Bjuland, Knut Jorgen/AAJ-1383-2020
OI Hernes, Susanne/0000-0001-6018-652X; Hol, Haakon
   Ramsland/0000-0001-5625-8308; Bjuland, Knut Jorgen/0000-0001-7573-4728
FU South-Eastern Norway Regional Health Authority [2013059]; Sorlandet
   Hospital HF
FX This work was funded by the South-Eastern Norway Regional Health
   Authority (Grant No. 2013059) and Sorlandet Hospital HF.
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NR 57
TC 22
Z9 23
U1 1
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD APR 12
PY 2019
VL 10
AR 807
DI 10.3389/fpsyg.2019.00807
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA HT1XL
UT WOS:000464357700001
PM 31031677
OA Green Published, gold, Green Accepted
DA 2023-08-17
ER

PT J
AU Simon, SS
   Yokomizo, JE
   Bottino, CMC
AF Simon, Sharon Sanz
   Yokomizo, Juliana Emy
   Bottino, Cassio M. C.
TI Cognitive intervention in amnestic Mild Cognitive Impairment: A
   systematic review
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Aging; Mild Cognitive Impairment; Memory; Neuropsychology; Cognitive
   interventions; Training; Rehabilitation; Functional neuroimaging
ID ALZHEIMERS-DISEASE PATIENTS; OLDER-ADULTS; PHYSICAL-ACTIVITY;
   REHABILITATION PROGRAM; EPISODIC MEMORY; BRAIN; DEMENTIA; RESERVE;
   METAANALYSIS; MCI
AB Mild Cognitive Impairment (MCI) represents a transitional state between normal aging and early dementia and is commonly associated with memory impairment (amnestic or A-MCI). Several studies have investigated therapeutic approaches to A-MCI, including cholinestherase inhibitors (I-ChEs), although this practice is still controversial. Thus, there is a current need to determine the effects of cognitive interventions either in combination with I-ChEs or alone. To assess the efficacy of such treatments, neuropsychological instruments and self-evaluated scoring of memory, mood, daily life activities and quality of life are employed. Recently, some studies have used functional magnetic resonance imaging (fMRI) in order to understand the neurobiological effects of these interventions. The aim of this systematic review is to investigate the effectiveness of cognitive interventions on the enhancement of learning abilities as well as their impacts on cognitive measurements of mood, everyday functioning and functional neuroimaging. This review also focused on the methodological aspects of such studies and attempted to introduce new perspectives on cognitive interventions in this population. The authors concluded that a-MCI patients are capable to learn new information and memory strategies. Although findings in standardized neuropsychological tests are limited, non-standardized cognitive measures and subjective measures show significant changes. Furthermore, fMRI reveals changes in the patterns of brain activation and increase of connectivity. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Simon, Sharon Sanz] Univ Sao Paulo, Old Age Res Grp PROTER, Inst Psychiat, Fac Med, BR-05403010 Sao Paulo, Brazil.
   Univ Sao Paulo, Old Age Res Grp PROTER, Dept Psychiat, Fac Med, BR-05403010 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Simon, SS (corresponding author), Univ Sao Paulo, Old Age Res Grp PROTER, Inst Psychiat, Fac Med, Rua Dr Ovidio Pires de Campos 785,3rd Floor, BR-05403010 Sao Paulo, Brazil.
EM sharon.sanzsimon@gmail.com; julianayokomizo@yahoo.com.br;
   cbottino@usp.br
RI Simon, Sharon Sanz/I-8457-2012; Bottino, Cassio MC/G-4052-2012
OI Simon, Sharon Sanz/0000-0003-2603-6215; 
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NR 96
TC 157
Z9 172
U1 2
U2 100
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD APR
PY 2012
VL 36
IS 4
BP 1163
EP 1178
DI 10.1016/j.neubiorev.2012.01.007
PG 16
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 928GJ
UT WOS:000302970900006
PM 22322184
DA 2023-08-17
ER

PT J
AU Lipardo, DS
   Tsang, WWN
AF Lipardo, Donald S.
   Tsang, William W. N.
TI Falls prevention through physical and cognitive training (falls PACT) in
   older adults with mild cognitive impairment: a randomized controlled
   trial protocol
SO BMC GERIATRICS
LA English
DT Article
DE Accidental falls; Older adults; Mild cognitive impairment; Physical
   exercise; Cognitive training; Falls rate
ID EXERCISE INTERVENTIONS; EXECUTIVE FUNCTION; ELDERLY-PEOPLE; INCREASED
   RISK; PERFORMANCE; MEMORY; EFFICACY; HEALTHY; BALANCE; GAIT
AB Background: The presence of mild cognitive impairment (MCI) in older adults increases their fall risk. While physical exercise is effective in reducing falls rate and risk of falls, and cognitive training in improving cognitive functioning in healthy older adults, their effectiveness in preventing falls and reducing risks of falls in MCI when administered simultaneously is not yet established. Therefore, this study aims to determine the effectiveness of combined physical and cognitive training in preventing falls and decreasing risks of falls among community-dwelling older persons with MCI.
   Methods/design: This is a single-blind, multicentre, randomized controlled trial. At least ninety-three community-dwelling older adults with MCI aged 60 or above will be recruited. They will be randomly allocated into four groups: Physical Training alone (PT), Cognitive Training alone (CT), combined Physical And Cognitive Training (PACT) and Waitlist Group (WG). The PT group will perform exercises (flexibility, endurance, strengthening, and balance training) for 60-90 min three times per week for 12 weeks. The CT group will be involved in a paper-based training focusing on orientation, memory, attention and executive functioning for 60-90 min per session, once a week for 12 weeks. The PACT group will undergo cognitive training incorporated in physical exercise for 60-90 min three times per week for 12 weeks. The WG will receive the intervention, combined physical and cognitive training, at a later date. Assessors blinded to participant allocation will conduct pre-intervention, post-intervention, and 6-month follow-up assessments. The primary outcome measure will be falls rate. The secondary outcome measures will be Physiologic Profile Assessment and Falls Risk for Older Persons in the Community, and assessments that evaluate cognitive, physical and psychological factors related to falls.
   Discussion: Considering the possible physical, social, financial and psychological consequences of a fall, we hope to provide insights on the effectiveness of combining physical and cognitive training on falls and fall-related factors for older adults with MCI. It is projected that the combined interventions will lead to significantly lower falls rate and reduced risk of falls compared to using single or no intervention.
C1 [Lipardo, Donald S.; Tsang, William W. N.] Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.
   [Lipardo, Donald S.] Univ Santo Tomas, Dept Phys Therapy, Coll Rehabil Sci, Manila, Philippines.
C3 Hong Kong Polytechnic University; University of Santo Tomas
RP Tsang, WWN (corresponding author), Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.
EM William.Tsang@polyu.edu.hk
RI Lipardo, Donald/AAV-3757-2020; Lipardo, Donald/N-3982-2015
OI Lipardo, Donald/0000-0001-8094-579X
FU Research Studentship Scholarship of The Hong Kong Polytechnic
   University.
FX There is no external funding for this project. The source of financial
   support will come from the Associated Money from the Research
   Studentship Scholarship of The Hong Kong Polytechnic University.
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NR 80
TC 16
Z9 16
U1 1
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD AUG 24
PY 2018
VL 18
AR 193
DI 10.1186/s12877-018-0868-2
PG 12
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GR6RB
UT WOS:000442784900004
PM 30143002
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Park, J
   Kim, SE
   Kim, EJ
   Lee, BI
   Jeong, JH
   Na, HR
   Choi, SH
   Kang, DY
   Park, KW
AF Park, Jinse
   Kim, Si-Eun
   Kim, Eun-Joo
   Lee, Byung In
   Jeong, Jee Hyang
   Na, Hae Ri
   Choi, Seong Hye
   Kang, Do-Young
   Park, Kyung Won
TI Effect of 12-week home-based cognitive training on cognitive function
   and brain metabolism in patients with amnestic mild cognitive impairment
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE mild cognitive impairment; cognitive training; brain PET
ID HEALTHY OLDER-ADULTS; PHARMACOLOGICAL-TREATMENT; ALZHEIMERS-DISEASE;
   INTERVENTION; DEMENTIA; PROGRAM; UPDATE; MEMORY
AB Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI).
   Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks.
   Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed.
   Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.
C1 [Park, Jinse; Kim, Si-Eun; Lee, Byung In] Inje Univ, Haueundae Paik Hosp, Dept Neurol, Busan, South Korea.
   [Kim, Eun-Joo] Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Neurol, Sch Med, Busan, South Korea.
   [Kim, Eun-Joo] Med Res Inst, Busan, South Korea.
   [Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Dept Neurol, Mokdong Hosp, Seoul, South Korea.
   [Na, Hae Ri] Bobath Mem Hosp, Dept Neurol, Seongnam, South Korea.
   [Choi, Seong Hye] Inha Univ, Dept Neurol, Sch Med, Incheon, South Korea.
   [Kang, Do-Young] Dong A Univ, Dept Nucl Med, Coll Med, Busan, South Korea.
   [Park, Kyung Won] Dong A Univ, Dept Neurol, Cognit Disorders & Dementia Ctr, Coll Med, Busan, South Korea.
   [Park, Kyung Won] Inst Convergence Biohlth, Busan, South Korea.
C3 Inje University; Pusan National University; Pusan National University
   Hospital; Ewha Womans University; Inha University; Dong A University;
   Dong A University
RP Park, KW (corresponding author), Dong A Univ, Dept Neurol, Coll Med, Daesingongwon Ro 26, Busan 602715, South Korea.
EM neuropark@dau.ac.kr
OI Kim, Eun Joo/0000-0002-8460-1377
FU Original Technology Research Program for Brain Science through the
   National Research Foundation of Korea (NRF) - Korean government (MSIP)
   [2014M3C7A1064752]; Eisai Korea Inc.
FX This study was supported by a grant from the Original Technology
   Research Program for Brain Science through the National Research
   Foundation of Korea (NRF) funded by the Korean government (MSIP)
   [2014M3C7A1064752] and Eisai Korea Inc. The abstract of this paper was
   presented at the Alzheimer's Association International Conference (AAIC)
   in Chicago (July 22-26, 2018) as a poster presentation with interim
   findings. The poster's abstract was published in "Poster Abstracts" in
   Alzheimer's & Dementia.
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NR 28
TC 11
Z9 13
U1 2
U2 10
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2019
VL 14
BP 1167
EP 1175
DI 10.2147/CIA.S200269
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA IF8RZ
UT WOS:000473362100001
PM 31303750
OA gold, Green Published, Green Submitted
DA 2023-08-17
ER

PT J
AU Li, R
   Geng, JW
   Yang, RZ
   Ge, YM
   Hesketh, T
AF Li, Ran
   Geng, Jiawei
   Yang, Runze
   Ge, Yumeng
   Hesketh, Therese
TI Effectiveness of Computerized Cognitive Training in Delaying Cognitive
   Function Decline in People With Mild Cognitive Impairment: Systematic
   Review and Meta-analysis
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE computerized cognitive training; mild cognitive impairment
ID OLDER-ADULTS; WORKING-MEMORY; PROGRAM
AB Background: With no current cure for mild cognitive impairment (MCI), delaying its progression could significantly reduce the disease burden and improve the quality of life for patients with MCI. Computerized cognitive training (CCT) has recently become a potential instrument for improvement of cognition. However, the evidence for its effectiveness remains limited.
   Objective: This systematic review aims to (1) analyze the efficacy of CCT on cognitive impairment or cognitive decline in patients with MCI and (2) analyze the relationship between the characteristics of CCT interventions and cognition-related health outcomes.
   Methods: A systematic search was performed using MEDLINE, Cochrane, Embase, Web of Science, and Google Scholar. Full texts of randomized controlled trials of CCT interventions in adults with MCI and published in English language journals between 2010 and 2021 were included. Overall global cognitive function and domain-specific cognition were pooled using a random-effects model. Sensitivity analyses were performed to determine the reasons for heterogeneity and to test the robustness of the results. Subgroup analyses were performed to identify the relationship between the characteristics of CCT interventions and cognition-related effectiveness.
   Results: A total of 18 studies with 1059 participants were included in this review. According to the meta-analysis, CCT intervention provided a significant but small increase in global cognitive function compared to that in the global cognitive function of the control groups (standardized mean difference=0.54, 95% CI 0.35-0.73; I-2=38%). CCT intervention also resulted in a marginal improvement in domain-specific cognition compared to that in the control groups, with moderate heterogeneity. Subgroup analyses showed consistent improvement in global cognitive behavior in the CCT intervention groups.
   Conclusions: This systematic review suggests that CCT interventions could improve global cognitive function in patients with MCI. Considering the relatively small sample size and the short treatment duration in all the included studies, more comprehensive trials are needed to quantify both the impact of CCT on cognitive decline, especially in the longer term, and to establish whether CCT should be recommended for use in clinical practice.
C1 [Li, Ran; Yang, Runze; Hesketh, Therese] UCL, Inst Global Hlth, London, England.
   [Li, Ran; Geng, Jiawei; Ge, Yumeng; Hesketh, Therese] Zhejiang Univ, Ctr Global Hlth, Sch Publ Hlth, Hangzhou, Zhejiang, Peoples R China.
   [Hesketh, Therese] UCL, Inst Global Hlth, 30 Guilford St, London WC1N 1EH, England.
C3 University of London; University College London; Zhejiang University;
   University of London; University College London
RP Hesketh, T (corresponding author), UCL, Inst Global Hlth, 30 Guilford St, London WC1N 1EH, England.
EM t.hesketh@ucl.ac.uk
OI Hesketh, Therese/0000-0002-7564-9221; Li, Ran/0000-0002-8432-9326; Geng,
   Jiawei/0000-0002-7622-2692
FU Centre of Global Health, Zhejiang University
FX This study was funded by the Centre of Global Health, Zhejiang
   University. The authors would like to thank Ranghao Bao for proofreading
   and RY's family for their spiritual support, particularly his
   grandmother, a brave and optimistic old lady with Alzheimer disease.
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NR 54
TC 6
Z9 7
U1 2
U2 2
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD OCT 27
PY 2022
VL 24
IS 10
AR e38624
DI 10.2196/38624
PG 15
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Medical Informatics
GA C8UX8
UT WOS:000964617700001
PM 36301590
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Hwang, HF
   Tseng, KC
   Chen, SJ
   Yu, WY
   Chen, CY
   Lin, MR
AF Hwang, Hei-Fen
   Tseng, Kuang-Chih
   Chen, Sy-Jou
   Yu, Wen-Yu
   Chen, Chih-Yi
   Lin, Mau-Roung
TI Effects of home-based computerized cognitive training and tai chi
   exercise on cognitive functions in older adults with mild cognitive
   impairment
SO AGING & MENTAL HEALTH
LA English
DT Article; Early Access
DE Cognitive decline; cognitive training; dementia; older adults; physical
   activity
ID PHYSICAL-ACTIVITY; AEROBIC EXERCISE; HEALTH-EDUCATION; DEMENTIA;
   PERFORMANCE; FALLS; SCALE; RISK; VALIDITY; DISEASE
AB BackgroundA randomized trial was conducted to investigate the effects of computerized cognitive training (CCT) and tai chi exercise (TCE) vs. health education (HE) on cognitive functions in 189 older adults with mild cognitive impairment (MCI).MethodsCognitive functions were assessed by the five-domain Mattis Dementia Rating Scale (MDRS) (attention, initiation/perseveration, construction, conceptualization, and memory) and the modified Telephone Interview of Cognitive Status (TICS-M), while the timed up and go (TUG), Tinetti's balance, activities of daily living (ADLs), and Activities-specific Balance Confidence (ABC) were also evaluated. Each intervention was delivered once a week for 6 months. All outcomes were followed up at 6 and 12 months of the study.ResultsCompared to HE, CCT increased scores on the MDRS's total, initiation/perseveration, construction, and conceptualization domains and on the TICS-M at 6 months and those on the MDRS's total, attention, construction, conceptualization, and memory domains and on the TICS-M at 12 months; TCE increased scores on the MDRS's total and construction domains and on the TICS-M at 6 months and those on the MDRS's total, attention, initiation/perseveration, and conceptualization domains and on the TICS-M at 12 months. Moreover, CCT improved the TUG at 6 and 12 months and Tinetti's balance at 12 months, and TCE improved the TUG at 6 and 12 months, Tinetti's balance, and ABC at 6 and 12 months, and ADLs at 12 months.ConclusionsThe effects of CCT and TCE on improving global cognition and certain cognitive domains for older MCI adults may have been small but they lasted for at least 12 months.
C1 [Hwang, Hei-Fen] Natl Taipei Univ Nursing & Hlth Sci, Dept Nursing, Taipei, Taiwan.
   [Hwang, Hei-Fen; Tseng, Kuang-Chih; Chen, Chih-Yi; Lin, Mau-Roung] Taipei Med Univ, Inst Injury Prevent & Control, Coll Publ Hlth, Taipei, Taiwan.
   [Chen, Sy-Jou] Triserv Gen Hosp, Natl Def Med Ctr, Dept Emergency Med, Taipei, Taiwan.
   [Yu, Wen-Yu] Taipei Med Univ Hosp, Dept Emergency Med, Taipei, Taiwan.
C3 National Taipei University of Nursing & Health Science (NTUNHS); Taipei
   Medical University; National Defense Medical Center; Tri-Service General
   Hospital; Taipei Medical University; Taipei Medical University Hospital
RP Lin, MR (corresponding author), Taipei Med Univ, Inst Injury Prevent & Control, Coll Publ Hlth, Taipei, Taiwan.
EM mrlin@tmu.edu.tw
RI Tseng, Kuang-Chih Josephine/IYS-1580-2023
OI Tseng, Kuang-Chih Josephine/0009-0002-0182-5250
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NR 56
TC 0
Z9 0
U1 1
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD 2023 JUN 17
PY 2023
DI 10.1080/13607863.2023.2225430
EA JUN 2023
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA K3LW4
UT WOS:001015498200001
PM 37365961
DA 2023-08-17
ER

PT J
AU Pallanti, S
   Grassi, E
   Knotkova, H
   Galli, G
AF Pallanti, Stefano
   Grassi, Eleonora
   Knotkova, Helena
   Galli, Giulia
TI Transcranial direct current stimulation in combination with cognitive
   training in individuals with mild cognitive impairment: a controlled
   3-parallel-arm study
SO CNS SPECTRUMS
LA English
DT Article; Early Access
DE Noninvasive brain stimulation; cognitive enhancement; neuromodulation;
   mild cognitive impairment; tDCS
ID NONINVASIVE BRAIN-STIMULATION; PREVALENCE; CORTEX
AB Objective Several studies showed that transcranial direct current stimulation (tDCS) enhances cognition in patients with mild cognitive impairment (MCI), however, whether tDCS leads to additional gains when combined with cognitive training remains unclear. This study aims to compare the effects of a concurrent tDCS-cognitive training intervention with either tDCS or cognitive training alone on a group of patients with MCI. Methods The study was a 3-parallel-arm study. The intervention consisted of 20 daily sessions of 20 minutes each. Patients (n = 62) received anodal tDCS to the left dorsolateral prefrontal cortex, cognitive training on 5 cognitive domains (orientation, attention, memory, language, and executive functions), or both. To examine intervention gains, we examined global cognitive functioning, verbal short-term memory, visuospatial memory, and verbal fluency pre- and post-intervention. Results All outcome measures improved after the intervention in the 3 groups. The improvement in global cognitive functioning and verbal fluency was significantly larger in patients who received the combined intervention. Instead, the intervention gain in verbal short-term memory and visuospatial memory was similar across the 3 groups. Discussion tDCS, regardless of the practicalities, could be an efficacious treatment in combination with cognitive training given the increased effectiveness of the combined treatment. Conclusions Future studies will need to consider individual differences at baseline, including genetic factors and anatomical differences that impact the electric field generated by tDCS and should also consider the feasibility of at-home treatments consisting of the application of tDCS with cognitive training.
C1 [Pallanti, Stefano; Knotkova, Helena] Albert Einstein Coll Med, Dept Family & Social Med, New York, NY 10461 USA.
   [Pallanti, Stefano; Grassi, Eleonora] Inst Neurosci, Florence, Italy.
   [Knotkova, Helena] MJHS Inst Innovat Palliat Care, New York, NY USA.
   [Galli, Giulia] Kingston Univ, Dept Psychol, Kingston, England.
C3 Yeshiva University; Kingston University
RP Pallanti, S (corresponding author), Albert Einstein Coll Med, Dept Family & Social Med, New York, NY 10461 USA.; Pallanti, S (corresponding author), Inst Neurosci, Florence, Italy.
EM stefanopallanti@yahoo.it
RI Pallanti, Stefano/HIR-2040-2022; Pallanti, Stefano/HTM-4081-2023
OI Galli, Giulia/0000-0001-9894-3514
CR Bennett DA, 2002, NEUROLOGY, V59, P198, DOI 10.1212/WNL.59.2.198
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NR 37
TC 0
Z9 0
U1 6
U2 10
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD 2022 SEP 12
PY 2022
AR PII S1092852922000979
DI 10.1017/S1092852922000979
EA SEP 2022
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 4W4YD
UT WOS:000860169200001
PM 36093863
OA Green Published
DA 2023-08-17
ER

PT J
AU Maeng, S
   Hong, JP
   Kim, WH
   Kim, H
   Cho, SE
   Kang, JM
   Na, KS
   Oh, SH
   Park, JW
   Bae, JN
   Cho, SJ
AF Maeng, Seri
   Hong, Jin Pyo
   Kim, Won-Hyoung
   Kim, Hyeyoung
   Cho, Seo-Eun
   Kang, Jae Myeong
   Na, Kyoung-Sae
   Oh, Seok-Hee
   Park, Jung Woon
   Bae, Jae Nam
   Cho, Seong-Jin
TI Effects of Virtual Reality-Based Cognitive Training in the Elderly with
   and without Mild Cognitive Impairment
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Virtual reality; Virtual reality-based cognitive therapy; Mild cognitive
   impairment
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; DEMENTIA; THERAPY
AB Objective This study aimed to introduce a 4-week long fully immersive virtual reality-based cognitive training (VRCT) program that could be applied for both a cognitively normal elderly population and patients with mild cognitive impairment (MCI). In addition, we attempted to investigate the neuropsychological effects of the VRCT program in each group. Methods A total of 56 participants, 31 in the MCI group and 25 in the cognitively normal elderly group, underwent eight sessions of VRCT for 4 weeks. In order to evaluate the effects of the VRCT, the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet was administered before and after the program. The program' s safety was assessed using a simulator sickness questionnaire (SSQ), and availability was assessed using the presence questionnaire. Results After the eighth session of the VRCT program, cognitive improvement was observed in the ability to learn new information, visuospatial constructional ability, and frontal lobe function in both groups. At the baseline evaluation, based on the SSQ, the MCI group complained of disorientation and nausea significantly more than the cognitively normal elderly group did. However, both groups showed a reduction in discomfort as the VRCT program progressed. Conclusion We conclude that our VRCT program helps improve cognition in both the MCI group and cognitively normal elderly group. Therefore, the VRCT is expected to help improve cognitive function in elderly populations with and without MCI.
C1 [Maeng, Seri; Kim, Won-Hyoung; Kim, Hyeyoung; Bae, Jae Nam] Inha Univ Hosp, Dept Psychiat, Incheon, South Korea.
   [Hong, Jin Pyo] Sungkyunkwan Univ, Samsung Med Ctr, Dept Psychiat, Sch Med, Seoul, South Korea.
   [Cho, Seo-Eun; Kang, Jae Myeong; Na, Kyoung-Sae; Cho, Seong-Jin] Gachon Univ, Dept Psychiat, Gil Med Ctr, 21 Nam Dong Daero 774beon Gil, Incheon 21565, South Korea.
   [Oh, Seok-Hee] Gachon Univ, Dept Comp Engn, Seongnam, South Korea.
   [Park, Jung Woon] Gachon Univ, Dept IT Convergence Engn, Grad Sch, Seongnam, South Korea.
C3 Inha University; Inha University Hospital; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Gachon University; Gachon University;
   Gachon University
RP Cho, SJ (corresponding author), Gachon Univ, Dept Psychiat, Gil Med Ctr, 21 Nam Dong Daero 774beon Gil, Incheon 21565, South Korea.; Bae, JN (corresponding author), Inha Univ, Dept Psychiat, Coll Med, 27 Inhang Ro, Incheon 22332, South Korea.
EM jnbae@inha.ac.kr; sjcho@gilhospital.com
OI Bae, Jae Nam/0000-0002-5024-6231; Maeng, Seri/0000-0001-6850-5548; Park,
   Jung woon/0000-0001-6271-4904; OH, SEOKHEE/0000-0001-7122-0463; Na,
   Kyoung-Sae/0000-0002-0148-9827; Kim, Won-Hyoung/0000-0002-6650-3685;
   Kim, Hyeyoung/0000-0002-2313-8892; Cho, Seo-Eun/0000-0002-3991-2192
FU Institute of Information & Communications Technology Planning &
   Evaluation (IITP) - Korean government (MSIT) [2017-0-00180]; Ministry of
   Science and ICT (MSIT), Korea, under the Information Technology Research
   Center (ITRC) support program [IITP-2020-2017-0-01630]
FX This work was supported by the Institute of Information & Communications
   Technology Planning & Evaluation (IITP) grant funded by the Korean
   government (MSIT) (No. 2017-0-00180, Development of complex biosignal
   response information-based intelligent VR (Virtual Reality) life care
   technology).; This research was supported by the Ministry of Science and
   ICT (MSIT), Korea, under the Information Technology Research Center
   (ITRC) support program (IITP-2020-2017-0-01630) supervised by the
   Institute for Information & Communications Technology Promotion (IITP).
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NR 32
TC 6
Z9 8
U1 10
U2 34
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUL
PY 2021
VL 18
IS 7
BP 619
EP 627
DI 10.30773/pi.2020.0446
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TT6CW
UT WOS:000680435700003
PM 34265200
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Gonzalez, PC
   Fong, KNK
   Brown, T
AF Gonzalez, Pablo Cruz
   Fong, Kenneth N. K.
   Brown, Ted
TI Transcranial direct current stimulation as an adjunct to cognitive
   training for older adults with mild cognitive impairment: A randomized
   controlled trial
SO ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
LA English
DT Article
DE Mild Cognitive Impairment; Cognitive Rehabilitation; Cognitive Training;
   Non-invasive Brain Stimulation; Transcranial Direct Current Stimulation
ID WORKING-MEMORY; DIAGNOSIS; DEMENTIA; MCI
AB Background: Cognitive training (CT) for individuals with mild cognitive impairment (MCI) may not be optimal for enhancing cognitive functioning. Coupling CT with transcranial direct current stimulation (tDCS) may maximize the strength of transmission across synaptic circuits in pathways that are stimulated by CT. The synergistic effects arising from this combination could be superior to those with administration of CT alone.
   Objectives: To investigate whether the receiving tDCS combined with CT is superior to CT alone on domain-specific and task-specific cognitive outcomes in older adults with MCI.
   Methods: This double-blind, sham-controlled randomized trial included 67 older adults with MCI assigned to 3 groups: 1) tDCS combined with CT (tDCS + CT), 2) sham tDCS combined with CT (sham tDCS + CT) and 3) CT alone. Nine sessions of computerized CT were administered to the 3 groups for 3 weeks. In addition, tDCS and sham tDCS was delivered to the left dorsolateral prefrontal cortex to the tDCS + CT and sham tDCS + CT groups, respectively, simultaneously with CT. Standardized cognitive assessments were performed at baseline, post-intervention, and at 6-week follow-up. Participants' performance in the CT tasks was rated every session.
   Results: The 3 groups showed improvements in global cognition and everyday memory (P < 0.017) after the intervention and at follow-up, with larger effect sizes in the tDCS + CT than other groups (d > 0.94) but with no significant differences between groups. Regarding CT outcomes, the groups showed significant differences in favour of the tDCS + CT group in decreasing the completion and reaction times of working memory and attention activities (P < 0.017).
   Conclusions: tDCS combined with CT was not superior to sham tDCS with CT and CT alone in its effects on domain-specific cognitive outcomes, but it did provide comparatively larger effect sizes and improve the processing speed of task-specific outcomes. (C) 2021 Elsevier Masson SAS. All rights reserved.
C1 [Gonzalez, Pablo Cruz; Fong, Kenneth N. K.] Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.
   [Brown, Ted] Monash Univ, Dept Occupat Therapy, Peninsula Campus, Frankston, Vic 3199, Australia.
C3 Hong Kong Polytechnic University; Monash University
RP Fong, KNK (corresponding author), Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.
EM rsnkfong@polyu.edu.hk
RI ; Fong, Kenneth N. K./F-9608-2014
OI Cruz, Pablo/0000-0001-9073-3061; Fong, Kenneth N. K./0000-0001-5909-4847
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NR 49
TC 3
Z9 5
U1 4
U2 10
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 1877-0657
EI 1877-0665
J9 ANN PHYS REHABIL MED
JI Ann. Phys. Rehabil. Med.
PD SEP
PY 2021
VL 64
IS 5
SI SI
AR 101536
DI 10.1016/j.rehab.2021.101536
EA JUL 2021
PG 10
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA WG9RK
UT WOS:000707327800008
PM 33957292
OA Bronze, Green Accepted
DA 2023-08-17
ER

PT J
AU Weng, WQ
   Liang, JM
   Xue, J
   Zhu, TF
   Jiang, YX
   Wang, JY
   Chen, SL
AF Weng, Wenqi
   Liang, Jiaming
   Xue, Jiang
   Zhu, Tingfei
   Jiang, Yuxing
   Wang, Jiayu
   Chen, Shulin
TI The Transfer Effects of Cognitive Training on Working Memory Among
   Chinese Older Adults With Mild Cognitive Impairment: A Randomized
   Controlled Trial
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE mild cognitive impairment; cognitive training; working memory; transfer
   effects; maintaining effects
ID ALZHEIMERS-DISEASE; INTERVENTION; GAIT; IMPACT; SPEED; DIAGNOSIS; MOCA;
   MCI; AGE
AB Objectives: To explore the transfer effects of cognitive training on working memory among older Chinese adults with mild cognitive impairment (MCI).
   Methods: Sixty-two MCI participants aged more than 60 years old were recruited by holding recruitment sessions in communities in China [33 for cognitive training, and 29 for mental leisure activities (MLA) control]. Cognitive functions, including working memory, execution function, reasoning ability, verbal ability, ability of daily living, were measured at three time-points (baseline, post-training and 3 months after training).
   Results: Compared to the MLA control, the cognitive training group showed significant effects in both the trained (working memory) and untrained (execution function and ability of daily living) domains. The effects of cognitive training on overall cognitive function, working memory and daily life ability of daily living of MCI could be maintained for at least 3 months, even without the cognitive training. Besides, complete mediating effects of cognitive training were found in executive function through working memory and working memory in ability of daily living though executive function, which suggests the presence of transfer effect of cognitive training.
   Conclusions: The present study supported that cognitive training could effectively improve working memory in elders with MCI. The training effects on working memory could transfer to other untrained areas (such as executive function), which also improved the comprehensive ability (ability of daily living). And the effects of training could largely persist for 3 months.
C1 [Weng, Wenqi; Liang, Jiaming; Xue, Jiang; Zhu, Tingfei; Jiang, Yuxing; Wang, Jiayu; Chen, Shulin] Zhejiang Univ, Dept Psychol, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Chen, SL (corresponding author), Zhejiang Univ, Dept Psychol, Hangzhou, Zhejiang, Peoples R China.
EM chenshulin@zju.edu.cn
RI Xue, Jiang/IUN-8749-2023
OI Xue, Jiang/0000-0002-3237-2330
FU Natural Science Foundation of Zhejiang Province [LY16H090011]
FX The project was supported by the Natural Science Foundation of Zhejiang
   Province (LY16H090011).
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NR 45
TC 25
Z9 28
U1 3
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD AUG 14
PY 2019
VL 11
AR 212
DI 10.3389/fnagi.2019.00212
PG 11
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA IQ4IJ
UT WOS:000480714000001
PM 31474850
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Martin, DM
   Mohan, A
   Alonzo, A
   Gates, N
   Gbadeyan, O
   Meinzer, M
   Sachdev, P
   Brodaty, H
   Loo, C
AF Martin, Donel M.
   Mohan, Adith
   Alonzo, Angelo
   Gates, Nicola
   Gbadeyan, Oyetunde
   Meinzer, Marcus
   Sachdev, Perminder
   Brodaty, Henry
   Loo, Colleen
TI A Pilot Double-Blind Randomized Controlled Trial of Cognitive Training
   Combined with Transcranial Direct Current Stimulation for Amnestic Mild
   Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE cognitive training; memory; mild cognitive impairment; randomized
   controlled trial; transcranial direct current stimulation; treatment
ID WORKING-MEMORY; OLDER-ADULTS; DIAGNOSIS; TDCS; QUESTIONNAIRE;
   PERFORMANCE; PREDICTORS
AB Background: There is currently no effective intervention for improving memory in people at increased risk for dementia. Cognitive training (CT) has been promising, though effects are modest, particularly at follow-up.
   Objective: To investigate whether adjunctive non-invasive brain stimulation (transcranial direct current stimulation, tDCS) could enhance the memory benefits of CT in amnestic mild cognitive impairment (aMCI).
   Methods: Participants with aMCI were randomized to receive CT with either Active tDCS (2 mA for 30 min and 0.016 mA for 30 min) or Sham tDCS (0.016 mA for 60 min) for 15 sessions over a period of 5 weeks in a double-blind, sham-controlled, parallel group clinical trial. The primary outcome measure was the California Verbal Learning Task 2nd Edition.
   Results: 68 participants commenced the intervention. Intention-to-treat (ITT) analysis showed that the CT+Active tDCS group significantly improved at post treatment (p = 0.033), and the CT+Sham tDCS group did not (p = 0.050), but there was no difference between groups. At the 3-month follow-up, both groups showed large-sized memory improvements compared to pre-treatment (CT+Active tDCS: p < 0.01, d = 0.99; CT+Sham tDCS: p < 0.01, d = 0.74), although there was no significant difference between groups.
   Conclusion: This study found that CT+Active tDCS did not produce greater memory improvement compared to CT+Sham tDCS. Large-sized memory improvements occurred in both conditions at follow-up. One possible interpretation, based on recent novel findings, is that low intensity tDCS (used as 'sham') may have contributed biological effects. Further work should use a completely inert tDCS sham condition.
C1 [Martin, Donel M.; Alonzo, Angelo; Loo, Colleen] Black Dog Inst, Sydney, NSW, Australia.
   [Martin, Donel M.; Mohan, Adith; Alonzo, Angelo; Gates, Nicola; Sachdev, Perminder; Brodaty, Henry; Loo, Colleen] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Gbadeyan, Oyetunde; Meinzer, Marcus] Univ Queensland, Ctr Clin Res, Brisbane, Qld, Australia.
   [Meinzer, Marcus] Univ Med Greifswald, Dept Neurol, Greifswald, Germany.
   [Sachdev, Perminder; Brodaty, Henry] Univ New South Wales, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.
   [Loo, Colleen] St George Hosp, South Eastern Sydney Hlth, Sydney, NSW, Australia.
C3 Black Dog Institute; University of New South Wales Sydney; University of
   Queensland; Greifswald Medical School; University of New South Wales
   Sydney; St George Hospital
RP Martin, DM (corresponding author), Black Dog Inst, Hosp Rd, Randwick, NSW 2031, Australia.
EM donel.martin@unsw.edu.au
RI Sachdev, Perminder/ABC-1137-2020; Loo, Colleen/HLX-9585-2023; Brodaty,
   Henry/E-2753-2010
OI Sachdev, Perminder/0000-0002-9595-3220; Brodaty,
   Henry/0000-0001-9487-6617
FU Dementia Australia Research Foundation; Thomas Foundation; Centre for
   Healthy Brain Ageing (CHeBA)
FX This work was funded by the Dementia Australia Research Foundation, the
   Thomas Foundation and the Centre for Healthy Brain Ageing (CHeBA). The
   authors would like to thank the research assistants Bronwyn Hegarty,
   Jessica Elmasry, Kevin Yeung and Nicholas Chand for their assistance
   with data collection. We thank all participants for their contribution
   to the study.
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NR 44
TC 15
Z9 18
U1 0
U2 9
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2019
VL 71
IS 2
BP 503
EP 512
DI 10.3233/JAD-190306
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA IZ4TF
UT WOS:000487075400011
PM 31424410
DA 2023-08-17
ER

PT J
AU Goumopoulos, C
   Skikos, G
   Frounta, M
AF Goumopoulos, Christos
   Skikos, Georgios
   Frounta, Maria
TI Feasibility and Effects of Cognitive Training with the COGNIPLAT Game
   Platform in Elderly with Mild Cognitive Impairment: Pilot Randomized
   Controlled Trial
SO GAMES FOR HEALTH JOURNAL
LA English
DT Article; Early Access
DE Mild cognitive impairment; Games; Multi-domain cognitive training;
   Randomized controlled trial; Pilot study; Multimodal interaction
ID MINI-MENTAL-STATE; VERBAL-LEARNING TEST; INSTRUMENTAL-ACTIVITIES;
   OLDER-ADULTS; SPACED RETRIEVAL; MEMORY; VALIDATION; DEPRESSION;
   ALZHEIMERS; DEMENTIA
AB This study examines the effectiveness of a new multi-domain multimodal cognitive training game platform, COGNIPLAT, in improving cognitive performance in elderly with mild cognitive impairment (MCI). The platform combines standard serious games and cognitive stimulation leveraging virtual and augmented reality technologies. A double-arm, evaluator-blinded randomized controlled trial was conducted with 21 elderly participants in the MCI spectrum, with 11 in the intervention group (INT) and 10 in the control group (CTL). Feasibility was assessed in terms of adherence, effective learning, and perceived usefulness. The INT attended 24 training sessions, 60 minutes long, twice a week, whereas the CTL engaged in normal daily activities and usual care. Results showed that the INT had a statistically significant change in the Montreal Cognitive Assessment score, stages List B Recall, Short-term delayed Recall, and Long-term delayed Recall of the Rey Auditory Verbal Learning Test (RAVLT), Trail Making Test-A and B test scores, Digit Span Test (DST) Forward Span, and Functional Activities Questionnaire score. A trend level difference was also found for the RAVLT Recognition and the DST Backward Span. No significant differences were found for the CTL in any of the metrics. The completion rate of the INT was 91%, and the attendance rate was 100% for participants who completed the follow-up segment of the study. The engagement level was high, and effective learning was observed between the participants. The perceived usability and usefulness of the game platform was assessed as high. This study provides evidence of a positive effect of a multi-domain multimodal-based cognitive training program in elderly with MCI, with broader benefits on cognition by inducing more cooperative transfer effects over different domains.
C1 [Goumopoulos, Christos; Skikos, Georgios] Univ Aegean, Informat & Commun Syst Engn Dept, GR-83200 Samos, Greece.
   [Frounta, Maria] Frontida Zois Ltd, Patras, Greece.
C3 University of Aegean
RP Goumopoulos, C (corresponding author), Univ Aegean, Informat & Commun Syst Engn Dept, GR-83200 Samos, Greece.
EM goumop@aegean.gr
OI Goumopoulos, Christos/0000-0003-1096-4439
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NR 64
TC 0
Z9 0
U1 2
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2161-783X
EI 2161-7856
J9 GAMES HEALTH J
JI Games Health J.
PD 2023 JUN 5
PY 2023
DI 10.1089/g4h.2023.0029
EA JUN 2023
PG 12
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Rehabilitation
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Rehabilitation
GA H9WE0
UT WOS:000999373800001
PM 37276027
DA 2023-08-17
ER

PT J
AU Zygouris, S
   Ntovas, K
   Giakoumis, D
   Votis, K
   Doumpoulakis, S
   Segkouli, S
   Karagiannidis, C
   Tzovaras, D
   Tsolaki, M
AF Zygouris, Stelios
   Ntovas, Konstantinos
   Giakoumis, Dimitrios
   Votis, Konstantinos
   Doumpoulakis, Stefanos
   Segkouli, Sofia
   Karagiannidis, Charalampos
   Tzovaras, Dimitrios
   Tsolaki, Magda
TI A Preliminary Study on the Feasibility of Using a Virtual Reality
   Cognitive Training Application for Remote Detection of Mild Cognitive
   Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Aging; Alzheimer's disease; computers; dementia; diagnosis; memory
   disorders; mild cognitive impairment; new technologies; practice effect;
   tablet PC
ID ALZHEIMERS-DISEASE; DEMENTIA; SUPERMARKET; ADULTS; TOOL
AB Background: It has been demonstrated that virtual reality (VR) applications can be used for the detection of mild cognitive impairment (MCI).
   Objective: The aim of this study is to provide a preliminary investigation on whether a VR cognitive training application can be used to detect MCI in persons using the application at home without the help of an examiner.
   Methods: Two groups, one of healthy older adults (n = 6) and one of MCI patients (n = 6) were recruited from Thessaloniki day centers for cognitive disorders and provided with a tablet PC with custom software enabling the self-administration of the Virtual Super Market (VSM) cognitive training exercise. The average performance (from 20 administrations of the exercise) of the two groups was compared and was also correlated with performance in established neuropsychological tests.
   Results: Average performance in terms of duration to complete the given exercise differed significantly between healthy (mu = 247.41 s/sd = 89.006) and MCI (mu = 454.52 s/sd = 177.604) groups, yielding a correct classification rate of 91.8% with a sensitivity and specificity of 94% and 89% respectively for MCI detection. Average performance also correlated significantly with performance in Functional Cognitive Assessment Scale (FUCAS), Test of Everyday Attention (TEA), and Rey Osterrieth Complex Figure test (ROCFT).
   Discussion: The VR application exhibited very high accuracy in detecting MCI while all participants were able to operate the tablet and application on their own. Diagnostic accuracy was improved compared to a previous study using data from only one administration of the exercise. The results of the present study suggest that remote MCI detection through VR applications can be feasible.
C1 [Zygouris, Stelios; Tsolaki, Magda] Aristotle Univ Thessaloniki, Dept Neurol 3, Sevillis 6, Thessaloniki 54633, Greece.
   [Zygouris, Stelios; Tsolaki, Magda] Heidelberg Univ, Network Aging Res, Bergheimer Str 58, D-69115 Heidelberg, Germany.
   [Zygouris, Stelios; Giakoumis, Dimitrios; Votis, Konstantinos] Cannot Not Design CND Design Res Org, Thessaloniki, Greece.
   [Ntovas, Konstantinos; Tsolaki, Magda] Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki, Greece.
   [Doumpoulakis, Stefanos; Segkouli, Sofia; Tzovaras, Dimitrios; Tsolaki, Magda] Ctr Res & Technol Hellas, Informat Technol Inst, Thessaloniki, Greece.
   [Segkouli, Sofia; Karagiannidis, Charalampos] Univ Thessaly, Dept Special Educ, Volos, Greece.
C3 Aristotle University of Thessaloniki; Ruprecht Karls University
   Heidelberg; Centre for Research & Technology Hellas; University of
   Thessaly
RP Zygouris, S (corresponding author), Aristotle Univ Thessaloniki, Dept Neurol 3, Sevillis 6, Thessaloniki 54633, Greece.
EM szygouris@gmail.com
RI Tzovaras, Dimitrios/ABB-9576-2021
OI Tzovaras, Dimitrios/0000-0001-6915-6722; Giakoumis,
   Dimitrios/0000-0003-1844-186X; Zygouris, Stelios/0000-0001-9384-1826;
   Tsolaki, Magda/0000-0002-2072-8010; votis,
   konstantinos/0000-0001-6381-8326
FU EU [690140]; Robert Bosch Foundation Stuttgart within the Graduate
   Program People with Dementia in General Hospitals (GPPDGH) at the
   Network Aging Research (NAR), University of Heidelberg, Germany; H2020
   Societal Challenges Programme [690140] Funding Source: H2020 Societal
   Challenges Programme
FX The work of authors from CERTH/ITI is partially supported by the EU
   H2020 funded project Frailsafe (Grant agreement no: 690140). Stelios
   Zygouris is a PhD/doctoral candidate at the Aristotle University of
   Thessaloniki, Greece/University of Heidelberg, Germany (joint program)
   and receives funding by the Robert Bosch Foundation Stuttgart within the
   Graduate Program People with Dementia in General Hospitals (GPPDGH),
   located at the Network Aging Research (NAR), University of Heidelberg,
   Germany. The authors wish to thank all the participants who volunteered
   in this study.
CR [Anonymous], 2012, DEM PUBL HLTH PRIOR
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NR 28
TC 46
Z9 49
U1 4
U2 51
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2017
VL 56
IS 2
BP 619
EP 627
DI 10.3233/JAD-160518
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EM1KT
UT WOS:000395077200017
PM 28035922
DA 2023-08-17
ER

PT J
AU Basak, C
   Qin, S
   O'Connell, MA
AF Basak, Chandramallika
   Qin, Shuo
   O'Connell, Margaret A.
TI Differential Effects of Cognitive Training Modules in Healthy Aging and
   Mild Cognitive Impairment: A Comprehensive Meta-Analysis of Randomized
   Controlled Trials
SO PSYCHOLOGY AND AGING
LA English
DT Article
DE cognitive training; MCI; healthy aging; far transfer; everyday
   functioning
ID ADULT AGE-DIFFERENCES; VISUOSPATIAL WORKING-MEMORY; EARLY
   ALZHEIMERS-DISEASE; OLDER-ADULTS; INDIVIDUAL-DIFFERENCES; EXECUTIVE
   FUNCTIONS; FLUID INTELLIGENCE; BRAIN PLASTICITY; VERBAL FLUENCY;
   ENHANCEMENT PROGRAM
AB This meta-analysis was designed to compare the effectiveness of 2 cognitive training modules. single-component training, which targets 1 specific cognitive ability, versus multicomponent training, which trains multiple cognitive abilities, on both trained abilities (near transfer) and untrained abilities (far transfer) in older adults. The meta-analysis also assessed whether individual differences in mental status interacted with the extent of transfer. Eligible randomized controlled trials (215 training studies) examined the immediate effects of cognitive training in either healthy aging (HA) or mild cognitive impairment (MCI). Results yielded an overall net-gain effect size (8) for the cognitive training of 0.28 (p < .001). These effects were similar across mental status and training modules, and were significant for both near (g = 0.37) and far (g = 0.22) transfer. Although all training modules yielded significant near transfer, only a few yielded significant far transfer. Single-component training of executive functions was most effective on near and far transfer, with processing speed training improving everyday functioning. All modules of multicomponent training (specific and nonspecific) yielded significant near and far transfer, including everyday functioning. Training effects on cognition were moderated by educational attainment and number of cognitive outcomes, but only in HA. These findings suggest that, in older adults, all modules of multicomponent training are more effective in engendering near and far transfer, including everyday functioning. when compared with single-component training modules.
C1 [Basak, Chandramallika; Qin, Shuo; O'Connell, Margaret A.] Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Richardson, TX 75080 USA.
C3 University of Texas System; University of Texas Dallas
RP Basak, C (corresponding author), Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Richardson, TX 75080 USA.
EM cbasak@utdallas.edu
OI Basak, Chandramallika/0000-0002-0364-0324; Qin, Shuo/0000-0003-0743-9254
FU National Institute on Aging [R56AG060052]; Annual Meeting for
   Psychonomic Society
FX This research was supported by a grant from National Institute on Aging
   (titled "Strategic Training to Optimize Neurocognitive Functions in
   Older Adults" under Award R56AG060052) to Chandramallika Basak.
   Preliminary results from this meta-analyses on a reduced dataset were
   presented at the Cognitive Aging Conference, Atlanta, 2018 and Annual
   Meeting for Psychonomic Society, 2017.
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NR 246
TC 40
Z9 43
U1 1
U2 26
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0882-7974
EI 1939-1498
J9 PSYCHOL AGING
JI Psychol. Aging
PD MAR
PY 2020
VL 35
IS 2
BP 220
EP 249
DI 10.1037/pag0000442
PG 30
WC Gerontology; Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA KQ1TK
UT WOS:000516712500008
PM 32011155
OA Bronze, Green Accepted
DA 2023-08-17
ER

PT J
AU Kim, H
   Hong, JP
   Kang, JM
   Kim, WH
   Maeng, S
   Cho, SE
   Na, KS
   Oh, SH
   Park, JW
   Cho, SJ
   Bae, JN
AF Kim, Hyeyoung
   Hong, Jin Pyo
   Kang, Jae Myeong
   Kim, Won-Hyoung
   Maeng, Seri
   Cho, Seo-Eun
   Na, Kyoung-Sae
   Oh, Seok Hee
   Park, Jung Woon
   Cho, Seong-Jin
   Bae, Jae Nam
TI Cognitive reserve and the effects of virtual reality-based cognitive
   training on elderly individuals with mild cognitive impairment and
   normal cognition
SO PSYCHOGERIATRICS
LA English
DT Article
DE cognitive dysfunction; cognitive reserve; virtual reality
ID ALZHEIMERS-DISEASE; SEX-DIFFERENCES; INTERVENTION; EDUCATION; DEMENTIA;
   MCI; EFFICACY; DECLINE; RISK
AB Background Cognitive reserve (CR) is a concept proposed to account for discrepancies between the extent of brain pathology and clinical manifestations of that pathology. This study aimed to explore the associations between CR and the effects of cognitive training using fully immersive virtual reality (VR).
   Methods A total of 44 older adults (22 cognitively normal, 22 with mild cognitive impairment) underwent eight cognitive training sessions using VR for a period of 4 weeks. CR was assessed using the Cognitive Reserve Index questionnaire (CRIq). To evaluate baseline cognitive function and the effects of VR training, the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery was administered to all participants before and after the training.
   Results Greater improvement in the total CERAD score was seen for cognitively normal participants with higher versus lower scores on the Education subdomain of the CRIq. Among patients with mild cognitive impairment, none of the CRIq subdomain scores (Education, Working Activity, Leisure Time) were related to a change in CERAD total scores. The CRIq total score did not predict the improvement of global cognition in either group.
   Conclusions This study revealed different impacts of CR on cognitive training according to the participants' cognitive status. It also suggests that employing three proxies of CR rather than using a composite score would provide a more accurate understanding of one's CR.
C1 [Kim, Hyeyoung; Kim, Won-Hyoung; Maeng, Seri; Bae, Jae Nam] Inha Univ Hosp, Dept Psychiat, Incheon, South Korea.
   [Kim, Hyeyoung] Gachon Univ, Coll Med, Gil Med Ctr, Dept Psychiat, Incheon, South Korea.
   [Hong, Jin Pyo] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea.
   [Kang, Jae Myeong; Cho, Seo-Eun; Na, Kyoung-Sae; Cho, Seong-Jin] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Psychiat, Seoul, South Korea.
   [Oh, Seok Hee] Gachon Univ, Dept Comp Engn, Seongnam, South Korea.
   [Park, Jung Woon] Gachon Univ, Grad Sch, Dept IT Convergence Engn, Seongnam, South Korea.
C3 Inha University; Inha University Hospital; Gachon University; Seoul
   National University (SNU); Sungkyunkwan University (SKKU); Samsung
   Medical Center; Gachon University; Gachon University
RP Bae, JN (corresponding author), Inha Univ Hosp, Dept Psychiat, Incheon, South Korea.; Cho, SJ (corresponding author), Gachon Univ, Coll Med, Gil Med Ctr, Dept Psychiat, Incheon, South Korea.
EM sjcho@gilhospital.com; jnbae@inha.ac.kr
OI Kim, Hyeyoung/0000-0002-2313-8892; Kim, Won-Hyoung/0000-0002-6650-3685
FU Institute of Information & Communications Technology Planning &
   Evaluation (IITP) - Korean government (MSIT) [2017-0-00180]; IITP grant
   under the IRTC (Information Technology Research Center) - Korean
   government (MSIT) [IITP-2020-2017-0-01 630]
FX This research was supported by the Institute of Information &
   Communications Technology Planning & Evaluation (IITP) grant funded by
   the Korean government (MSIT) (No. 2017-0-00180, Development of Complex
   biosignal response information based intelligent VR(Virtual Reality)
   life care technology) and an IITP grant under the IRTC (Information
   Technology Research Center) support program funded by the Korean
   government (MSIT) (IITP-2020-2017-0-01 630).
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NR 40
TC 7
Z9 7
U1 2
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1346-3500
EI 1479-8301
J9 PSYCHOGERIATRICS
JI Psychogeriatrics
PD JUL
PY 2021
VL 21
IS 4
BP 552
EP 559
DI 10.1111/psyg.12705
EA MAY 2021
PG 8
WC Geriatrics & Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Psychiatry
GA TC8WO
UT WOS:000645955900001
PM 33934441
DA 2023-08-17
ER

PT J
AU Lissek, VJ
   Ben Abdallah, H
   Praetorius, A
   Ohmann, T
   Suchan, B
AF Lissek, Vanessa J.
   Ben Abdallah, Heithem
   Praetorius, Arthur
   Ohmann, Tobias
   Suchan, Boris
TI go4cognition: Combined Physiological and Cognitive Intervention in Mild
   Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Cognitive training; mild cognitive impairment; multi- component
   intervention; physiological intervention; simultaneous stimulation of
   physical and cognitive abilities
ID ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; OLDER-ADULTS; EXERCISE
   INTERVENTION; LEISURE ACTIVITIES; BRAIN RESERVE; DEMENTIA; RISK; MEMORY;
   REHABILITATION
AB Background: While cognitive interventions in mild cognitive impairment (MCI) show positive effects on cognitive performance, physical activity appear to slow down cognitive decline, suggesting a relationship between both factors. However, previous combined programs that have shown significant improvement in cognitive function in MCI have typically trained cognition and physical functioning separately.
   Objective: This project aimed at evaluating two group interventions combining the stimulation of physical and cognitive domains in individuals with MCI: Simultaneous stimulation of physical and cognitive skills in comparison to a standardized training, which stimulates cognitive and physical functions separately.
   Methods: The study was designed as a randomized controlled trial. The first group was trained on the SpeedCourt (R) system while the second group completed the standardized Fitfor100 program. Training was completed by a total of 39 subjects with diagnosed MCI as determined by the CERAD (SpeedCourt (R): 24 subjects, Fitfor100:15 individuals).
   Results: There were significant improvements of physical factors (e.g., hand strength and balance) in both groups. Improvement in the CERAD total score allowed for a post interventional classification of all participants into non-MCI and MCI. This effect persisted over a period of three months. Both forms of intervention were found to be effective in improving various cognitive functions which persisted for a period of three months.
   Conclusion: Both evaluated non-pharmacological, multicomponent interventions, which combined physical and cognitive training in a social setting showed improvement of cognitive functions leading to a persistent classification of former MCI patients in non-MCI patients.
C1 [Lissek, Vanessa J.; Suchan, Boris] Ruhr Univ Bochum, Inst Cognit Neurosci, Clin Neuropsychol Neuropsychol Therapy Ctr, Univ Str 150, D-44780 Bochum, Germany.
   [Ben Abdallah, Heithem; Ohmann, Tobias] BG Klinikum Duisburg gGmbH, Res Dept, Duisburg, Germany.
   [Praetorius, Arthur] BG Klinikum Duisburg gGmbH, Dept Arthroscop Surg Sports Traumatol & Sports Me, Duisburg, Germany.
C3 Ruhr University Bochum
RP Lissek, VJ (corresponding author), Ruhr Univ Bochum, Inst Cognit Neurosci, Clin Neuropsychol Neuropsychol Therapy Ctr, Univ Str 150, D-44780 Bochum, Germany.
EM Vanessa.Lissek@ruhr-uni-bochum.de
FU Leitmarkt Agentur.NRW; European Union; state government of North
   Rhine-Westfalia, Germany
FX This work was supported by the Leitmarkt Agentur.NRW, the European Union
   and the state government of North Rhine-Westfalia, Germany. Authors'
   disclosures available online
   (https://www.j-alz.com/manuscript-disclosures/22-0145r2).
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NR 83
TC 1
Z9 2
U1 4
U2 6
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2022
VL 89
IS 2
BP 449
EP 462
DI 10.3233/JAD-220145
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 4P9KB
UT WOS:000855706900007
PM 35871331
DA 2023-08-17
ER

PT J
AU Chen, YF
   Zhou, W
   Hong, ZJ
   Hu, RR
   Guo, ZB
   Liu, S
   Zhang, L
AF Chen, Yifan
   Zhou, Wei
   Hong, Zijing
   Hu, Rongrong
   Guo, Zhibin
   Liu, Shen
   Zhang, Lin
TI The effects of combined cognitive training on prospective memory in
   older adults with mild cognitive impairment
SO SCIENTIFIC REPORTS
LA English
DT Article
ID WORKING-MEMORY; AGE-DIFFERENCES; FAR TRANSFER; PLASTICITY; SYMPTOMS;
   CHILDREN; PROGRAM
AB This study aimed to assess the effects of combined cognitive training on prospective memory ability of older adults with mild cognitive impairment (MCI). A total of 113 participants were divided into a control group and three intervention groups. Over three months, the control group received only community education without any training, whereas for the first six weeks, an executive function training group received executive function training, a memory strategy training group received semantic encoding strategy training, and the combined cognitive training group received executive function training twice a week for the first six weeks, and semantic encoding strategy training twice a week for the next six weeks. The combined cognitive training group showed improvement on the objective neuropsychological testing (Montreal Cognitive Assessment scale). The memory strategy training group showed improvement on the self-evaluation scales (PRMQ-PM). Combined cognitive training improved the prospective memory and cognitive function of older adults with MCI.
C1 [Chen, Yifan; Zhou, Wei; Hong, Zijing; Hu, Rongrong; Guo, Zhibin; Zhang, Lin] Ningbo Univ, Dept & Inst Psychol, 616 Fenghua Rd, Ningbo 315211, Peoples R China.
   [Zhou, Wei; Hong, Zijing] Jinan Univ, Sch Management, Guangzhou, Peoples R China.
   [Liu, Shen] Univ Sci & Technol China, Sch Humanities & Social Sci, 96 Jinzhai Rd, Hefei 230022, Peoples R China.
C3 Ningbo University; Jinan University; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS
RP Zhang, L (corresponding author), Ningbo Univ, Dept & Inst Psychol, 616 Fenghua Rd, Ningbo 315211, Peoples R China.; Liu, S (corresponding author), Univ Sci & Technol China, Sch Humanities & Social Sci, 96 Jinzhai Rd, Hefei 230022, Peoples R China.
EM liushenpsy@ustc.edu.cn; zhanglin1@nbu.edu.cn
FU China Postdoctoral Science Foundation [2020M682054]; Youth Project of
   Philosophy and Social Science Foundation in Anhui Province of 2020
   [AHSKQ2020D180]; K. C. Wong Magna Fund at Ningbo University
FX This work was supported by Project Funded by China Postdoctoral Science
   Foundation (2020M682054), the Youth Project of Philosophy and Social
   Science Foundation in Anhui Province of 2020 (AHSKQ2020D180) and the K.
   C. Wong Magna Fund at Ningbo University.
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NR 50
TC 3
Z9 3
U1 3
U2 26
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 2
PY 2021
VL 11
IS 1
AR 15659
DI 10.1038/s41598-021-95126-z
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA UA5KY
UT WOS:000685201500016
PM 34341403
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Jean, L
   Simard, M
   Wiederkehr, S
   Bergeron, ME
   Turgeon, Y
   Hudon, C
   Tremblay, I
   van Reekum, R
AF Jean, Leonie
   Simard, Martine
   Wiederkehr, Sandra
   Bergeron, Marie-Eve
   Turgeon, Yves
   Hudon, Carol
   Tremblay, Isabelle
   van Reekum, Robert
TI Efficacy of a cognitive training programme for mild cognitive
   impairment: Results of a randomised controlled study
SO NEUROPSYCHOLOGICAL REHABILITATION
LA English
DT Article
DE Errorless learning; Spaced retrieval; Memory disorders; Preclinical
   dementia; Non-pharmacological intervention
ID EXECUTIVE FUNCTION SYSTEM; FACE-NAME ASSOCIATIONS; ALZHEIMERS-DISEASE;
   OLDER-ADULTS; MEMORY IMPAIRMENT; EPISODIC MEMORY; NEUROPSYCHOLOGICAL
   PREDICTION; PSYCHOMETRIC PROPERTIES; REHABILITATION PROGRAM; EARLY
   INTERVENTION
AB This study aimed to determine the efficacy of cognitive training in a 10-week randomised controlled study involving 22 individuals presenting with mild cognitive impairment of the amnestic type (MCI-A). Participants in the experimental group (n = 11) learned face-name associations using a paradigm combining errorless (EL) learning and spaced retrieval (SR) whereas participants in the control group (n = 11) were trained using an errorful (EF) learning paradigm. Psycho-educational sessions on memory were also provided to all participants. After neuropsychological screening and baseline evaluations, the cognitive training took place in 6 sessions over a 3-week period. The post-training and follow-up evaluations, at one and four weeks respectively, were performed by research assistants blind to the participant's study group. The results showed that regardless of the training condition, all participants improved their capacity to learn face-name associations. A significant amelioration was also observed in participant satisfaction regarding their memory functioning and in the frequency with which the participants used strategies to support memory functions in daily life. The absence of difference between groups on all variables might be partly explained by the high variability of scores within the experimental group. Other studies are needed in order to verify the efficacy of EL learning and SR over EF in MCI-A.
C1 [Jean, Leonie; Simard, Martine; Bergeron, Marie-Eve; Hudon, Carol; van Reekum, Robert] Univ Laval, Sch Psychol, Quebec City, PQ G1V 0A6, Canada.
   [Jean, Leonie; Simard, Martine; Wiederkehr, Sandra; Bergeron, Marie-Eve; Hudon, Carol; Tremblay, Isabelle] Univ Laval Robert Giffard, Ctr Rech, Quebec City, PQ, Canada.
   [Turgeon, Yves] Restigouche Hlth Author, Healthy Aging & Wellness Ctr, Campbellton, NB, Canada.
   [van Reekum, Robert] Univ Toronto, Div Geriatr Psychiat, Toronto, ON M5S 1A1, Canada.
C3 Laval University; Laval University; University of Toronto
RP Jean, L (corresponding author), Univ Laval, Sch Psychol, Quebec City, PQ G1V 0A6, Canada.
EM Leonie.Jean.1@ulaval.ca
RI Simard/Q-9675-2019
OI Simard/0000-0003-1257-8275; Hudon, Carol/0000-0002-7554-3187
FU Alzheimer Society of Canada (ASC); Fonds de la Recherche en Sante du
   Quebec (FRSQ); Canadian Institutes of Health Research (CIHR)-Institute
   of Aging (IA); FORMSAV; ASC; Fonds Quebecois de la Recherche sur la
   Nature et les Technologies (FQRNT)
FX Leonie Jean was supported by doctoral training grants awarded by the
   Alzheimer Society of Canada (ASC) co-funded by the Fonds de la Recherche
   en Sante du Quebec (FRSQ) and the Canadian Institutes of Health Research
   (CIHR)-Institute of Aging (IA). Marie-Eve Bergeron is supported by a
   doctoral training grant awarded by FORMSAV. Martine Simard and Carol
   Hudon are supported by research grants from the ASC, and were involved
   in research funded by the CIHR-IA. Sandra Wiederkehr was supported by
   doctoral training grants awarded by the Fonds Quebecois de la Recherche
   sur la Nature et les Technologies (FQRNT) and FORMSAV.
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NR 96
TC 70
Z9 75
U1 0
U2 36
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0960-2011
EI 1464-0694
J9 NEUROPSYCHOL REHABIL
JI Neuropsychol. Rehabil.
PY 2010
VL 20
IS 3
BP 377
EP 405
AR PII 918012391
DI 10.1080/09602010903343012
PG 29
WC Neurosciences; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychology
GA 598RZ
UT WOS:000277857200004
PM 20029715
DA 2023-08-17
ER

PT J
AU Zygouris, S
   Giakoumis, D
   Votis, K
   Doumpoulakis, S
   Ntovas, K
   Segkouli, S
   Karagiannidis, C
   Tzovaras, D
   Tsolaki, M
AF Zygouris, Stelios
   Giakoumis, Dimitrios
   Votis, Konstantinos
   Doumpoulakis, Stefanos
   Ntovas, Konstantinos
   Segkouli, Sofia
   Karagiannidis, Charalampos
   Tzovaras, Dimitrios
   Tsolaki, Magda
TI Can a Virtual Reality Cognitive Training Application Fulfill a Dual
   Role? Using the Virtual Supermarket Cognitive Training Application as a
   Screening Tool for Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Aging; Alzheimer's disease; computers; dementia; diagnosis; memory
   disorders; mild cognitive impairment; user-computer interface
ID ALZHEIMERS-DISEASE; OLDER-ADULTS; PRIMARY-CARE; VALIDATION; PERFORMANCE;
   GUIDELINES; VALIDITY; MOCA; MCI
AB Background: Recent research advocates the potential of virtual reality (VR) applications in assessing cognitive functions highlighting the possibility of using a VR application for mild cognitive impairment (MCI) screening.
   Objective: The aim of this study is to investigate whether a VR cognitive training application, the virtual supermarket (VSM), can be used as a screening tool for MCI.
   Methods: Two groups, one of healthy older adults (n=21) and one of MCI patients (n=34), were recruited from day centers for cognitive disorders and administered the VSM and a neuropsychological test battery. The performance of the two groups in the VSM was compared and correlated with performance in established neuropsychological tests. At the same time, the effectiveness of a combination of traditional neuropsychological tests and the VSM was examined.
   Results: VSM displayed a correct classification rate (CCR) of 87.30% when differentiating between MCI patients and healthy older adults, while it was unable to differentiate between MCI subtypes. At the same time, the VSM correlates with various established neuropsychological tests. A limited number of tests were able to improve the CCR of the VSM when combined with the VSM for screening purposes.
   Discussion: VSM appears to be a valid method of screening for MCI in an older adult population though it cannot be used for MCI subtype assessment. VSM's concurrent validity is supported by the large number of correlations between the VSM and established tests. It is considered a robust test on its own as the inclusion of other tests failed to improve its CCR significantly.
C1 [Zygouris, Stelios; Ntovas, Konstantinos; Tsolaki, Magda] Aristotle Univ Thessaloniki, Dept Neurol 3, Thessaloniki 54632, Greece.
   [Giakoumis, Dimitrios; Votis, Konstantinos; Doumpoulakis, Stefanos; Tzovaras, Dimitrios] Ctr Res & Technol Hellas, Informat Technol Inst, Thessaloniki, Greece.
   [Segkouli, Sofia; Tsolaki, Magda] Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki, Greece.
   [Karagiannidis, Charalampos] Univ Thessaly, Dept Special Educ, Volos, Greece.
C3 Aristotle University of Thessaloniki; Centre for Research & Technology
   Hellas; University of Thessaly
RP Zygouris, S (corresponding author), Aristotle Univ Thessaloniki, Dept Neurol 3, Sevillis 6, Thessaloniki 54632, Greece.
EM szygouris@gmail.com
RI Tzovaras, Dimitrios/ABB-9576-2021
OI Tzovaras, Dimitrios/0000-0001-6915-6722; Tsolaki,
   Magda/0000-0002-2072-8010; Zygouris, Stelios/0000-0001-9384-1826; votis,
   konstantinos/0000-0001-6381-8326; Giakoumis,
   Dimitrios/0000-0003-1844-186X
FU Greek Government; European Union
FX The authors received financial and material support from the Greek
   Government and the European Union under the umbrella of the project "E
   upsilon-NOH Sigma H Sigma - Ambient Intelligence System for the
   Prognosis, Diagnosis, Monitoring and Empowerment of Patients with
   Cognitive Disorders". This study was completed in collaboration with the
   Aristotle University of Thessaloniki, the Greek Association of
   Alzheimer's Disease and Relative Disorders (GAADRD) and the Information
   Technologies Institute (ITI).
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NR 28
TC 82
Z9 86
U1 4
U2 35
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2015
VL 44
IS 4
BP 1333
EP 1347
DI 10.3233/JAD-141260
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA CC0BW
UT WOS:000350001000026
PM 25428251
DA 2023-08-17
ER

PT J
AU Klados, MA
   Styliadis, C
   Frantzidis, CA
   Paraskevopoulos, E
   Bamidis, PD
AF Klados, Manousos A.
   Styliadis, Charis
   Frantzidis, Christos A.
   Paraskevopoulos, Evangelos
   Bamidis, Panagiotis D.
TI Beta-Band Functional Connectivity is Reorganized in Mild Cognitive
   Impairment after Combined Computerized Physical and Cognitive Training
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE aging; brain plasticity; cognitive training; electroencephalography;
   mild cognitive impairment; graph theory; physical exercise; resting
   states
ID RESTING-STATE NETWORKS; DEFAULT-MODE NETWORK; ALZHEIMERS-DISEASE;
   OLDER-ADULTS; BRAIN PLASTICITY; EEG SYNCHRONIZATION; WORKING-MEMORY;
   AGING BRAIN; LIFE-STYLE; HEALTHY
AB Physical and cognitive idleness constitute significant risk factors for the clinical manifestation of age-related neurodegenerative diseases. In contrast, a physically and cognitively active lifestyle may restructure age-declined neuronal networks enhancing neuroplasticity. The present study, investigated the changes of brain's functional network in a group of elderly individuals at risk for dementia that were induced by a combined cognitive and physical intervention scheme. Fifty seniors meeting Petersen's criteria of Mild Cognitive Impairment were equally divided into an experimental (LLM), and an active control (AC) group. Resting state electroencephalogram (EEG) was measured before and after the intervention. Functional networks were estimated by computing the magnitude square coherence between the time series of all available cortical sources as computed by standardized low resolution brain electromagnetic tomography (sLORETA). A statistical model was used to form groups' characteristic weighted graphs. The introduced modulation was assessed by networks' density and nodes' strength. Results focused on the beta band (12-30 Hz) in which the difference of the two networks' density is maximum, indicating that the structure of the LLM cortical network changes significantly due to the intervention, in contrast to the network of AC. The node strength of LLM participants in the beta band presents a higher number of bilateral connections in the occipital, parietal, temporal and prefrontal regions after the intervention. Our results show that the combined training scheme reorganizes the beta band functional connectivity of MCI patients. ClinicalTrials.gov Identifier: NCT02313935 https://clinicaltrials.gov/ct2/show/NCT02313935.
C1 [Klados, Manousos A.; Styliadis, Charis; Frantzidis, Christos A.; Paraskevopoulos, Evangelos; Bamidis, Panagiotis D.] Aristotle Univ Thessaloniki, Sch Med, Fac Hlth Sci, Med Phys Lab, GR-54006 Thessaloniki, Greece.
   [Klados, Manousos A.] Max Planck Inst Human Cognit & Brain Sci, Res Grp Neuroanat & Connect, Leipzig, Germany.
C3 Aristotle University of Thessaloniki; Max Planck Society
RP Bamidis, PD (corresponding author), Aristotle Univ Thessaloniki, Sch Med, Fac Hlth Sci, Med Phys Lab, GR-54006 Thessaloniki, Greece.
EM bamidis@med.auth.gr
RI Styliadis, Charis/ABD-8111-2020; Bamidis, Panagiotis/AAK-3556-2020;
   Klados, Manousos/M-4994-2013
OI Styliadis, Charis/0000-0001-7383-2439; Bamidis,
   Panagiotis/0000-0002-9936-5805; Klados, Manousos/0000-0002-1629-6446;
   Paraskevopoulos, Evangelos/0000-0003-4063-4182
FU European Long Lasting memories (LLM) project [CIP-ICTPSP. 2008.1.4,
   238904]
FX This study was funded by the European CIP-ICTPSP. 2008.1.4 Long Lasting
   memories (LLM) project (Project No. 238904)
   (http://www.longlastingmemories.eu/). LLM run from June 2009 to March
   2012 under the co-ordination of the author PR and it was a partnership
   of 5 EU Member countries (Austria, France, Greece, Spain, and the
   Cyprus). The authors would like to thank Vicky Zilidou, Anastasia
   Semertzidou, for efficiently supporting EEG data acquisition, Antonis
   Billis, Giorgos Bamparopoulos and Evdokimos Konstantinidis for software
   development and technical support, Evangelia Romanopoulou, Maria
   Karagianni, Eirini Grigoriadou, Aristea Ladas, Athina Kyrillidou,
   Anthoula Tsolaki, Ana B. Vivas, and Magda Tsolaki for pilot execution
   and neuropsychologicalineurological assessments.
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NR 94
TC 38
Z9 40
U1 0
U2 43
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD FEB 29
PY 2016
VL 10
AR 55
DI 10.3389/fnins.2016.00055
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DF1IW
UT WOS:000371094100001
PM 26973445
OA gold, Green Accepted, Green Published
DA 2023-08-17
ER

PT J
AU Lipardo, DS
   Aseron, AMC
   Kwan, MM
   Tsang, WW
AF Lipardo, Donald S.
   Aseron, Anne Marie C.
   Kwan, Marcella M.
   Tsang, William W.
TI Effect of Exercise and Cognitive Training on Falls and Fall-Related
   Factors in Older Adults With Mild Cognitive Impairment: A Systematic
   Review
SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
LA English
DT Review
DE Cognitive dysfunction; Cognitive therapy; Exercise; Frail elderly;
   Rehabilitation
ID MULTICOMPONENT EXERCISE; EXECUTIVE FUNCTION; RISK; GAIT; PREVENTION;
   PEOPLE; PERFORMANCE; BALANCE; MEMORY; TRIAL
AB Objective: To evaluate the effect of exercise and cognitive training on falls reduction and on factors known to be associated with falls among community-dwelling older adults with mild cognitive impairment (MCI).
   Data Sources: Seven databases (PubMed, CINAHL, Cochrane Library, Web of Science, ProQuest, ProQuest Dissertations and Theses, Digital Dissertation Consortium) and reference lists of pertinent articles were searched.
   Study Selection: Randomized controlled trials (RCTs) on the effect of exercise, cognitive training, or a combination of both on falls and factors associated with falls such as balance, lower limb muscle strength, gait, and cognitive function among community-dwelling older adults with MCI were included.
   Data Extraction: Data were extracted using the modified Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) tool. Study quality was assessed using the JBI-MAStARI appraisal instrument.
   Data Synthesis: Seventeen RCTs (1679 participants; mean age +/- SD, 74.4 +/- 2.4y) were included. Exercise improved gait speed and global cognitive function in MCI; both are known factors associated with falls. Cognitive training alone had no significant effect on cognitive function, while combined exercise and cognitive training improved balance in MCI. Neither fall rate nor the number of fallers was reported in any of the studies included.
   Conclusions: This review suggests that exercise, and combined exercise and cognitive training improve specific factors associated with falls such as gait speed, cognitive function, and balance in MCI. Further research on the direct effect of exercise and cognitive training on the fall rate and incidence in older adults with MCI with larger sample sizes is highly recommended. (C) 2017 by the American Congress of Rehabilitation Medicine.
C1 [Lipardo, Donald S.; Tsang, William W.] Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Hong Kong, Peoples R China.
   [Lipardo, Donald S.; Aseron, Anne Marie C.] Univ Santo Tomas, Coll Rehabil Sci, Manila, Philippines.
   [Kwan, Marcella M.] Univ Queensland, Sch Med, Rural Clin Sch, Brisbane, Qld, Australia.
C3 Hong Kong Polytechnic University; University of Santo Tomas; University
   of Queensland
RP Tsang, WW (corresponding author), Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.
EM William.Tsang@polyu.edu.hk
RI Lipardo, Donald/AAV-3757-2020; Kwan, Marcella Mun-San/J-3555-2013;
   Lipardo, Donald/N-3982-2015
OI Kwan, Marcella Mun-San/0000-0002-3317-5056; Tsang, William Wai
   Nam/0000-0002-3549-2346; Lipardo, Donald/0000-0001-8094-579X; Aseron,
   Anne Marie/0000-0003-0858-6299
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NR 64
TC 50
Z9 54
U1 4
U2 57
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0003-9993
EI 1532-821X
J9 ARCH PHYS MED REHAB
JI Arch. Phys. Med. Rehabil.
PD OCT
PY 2017
VL 98
IS 10
BP 2079
EP 2096
DI 10.1016/j.apmr.2017.04.021
PG 18
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation; Sport Sciences
GA FJ5LZ
UT WOS:000412794300020
PM 28554873
DA 2023-08-17
ER

PT J
AU Xing, Y
   Zhu, ZD
   Du, YF
   Zhang, JJ
   Qu, QM
   Sun, L
   Li, Y
   Guo, YJ
   Peng, GP
   Liu, Y
   Yu, YY
   Qiao, YC
   Xie, BJ
   Shi, XR
   Lu, J
   Jia, JP
   Tang, Y
AF Xing, Yi
   Zhu, Zude
   Du, Yifeng
   Zhang, Junjian
   Qu, Qiumin
   Sun, Li
   Li, Yang
   Guo, Yanjun
   Peng, Guoping
   Liu, Yong
   Yu, Yueyi
   Qiao, Yuchen
   Xie, Beijia
   Shi, Xinrui
   Lu, Jie
   Jia, Jianping
   Tang, Yi
TI The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild
   coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center
   Randomized Controlled Trial
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Cognitive training; mild cognitive impairment; non-pharmacological
   intervention; randomized controlled clinical trial
ID DEMENTIA; PREVALENCE; SHANGHAI; SCALE
AB Background: Amnestic mild cognitive impairment (aMCI) is often the prodromal stage of Alzheimer's disease (AD). Although previous studies have suggested that computerized cognitive training is an effective non-pharmacological intervention for aMCI, large-sample, randomized controlled studies are warranted to provide a high level of evidence.
   Objective: To identify the efficacy of computerized cognitive training for aMCI.
   Methods: This study will include 260 patients diagnosed with aMCI from 8 centers in China. A computerized multi-domain adaptive training program will be used in this study, and the targeted cognitive domains include memory, attention, language, and executive function. The patients will be randomized into either a cognitive-training group or an active-control group. The intervention is a 12-week internet-based cognitive training performed for 40 minutes per day, 4 days a week. Neuropsychological assessments and structural and functional MRI will be obtained at baseline, at the end of the intervention, and 6 months after randomization. The primary outcome will be the global cognitive function score assessed by Montreal Cognitive Assessment. The secondary outcomes include changes in other neuropsychological assessments and neuroplasticity changes measured by structural and functional MRI.
   Results: The trial is currently ongoing, and it is anticipated that recruitment will be completed in December 2020.
   Conclusion: This multi-center, large-sample, randomized controlled trial will investigate the short and long-term effects of computerized cognitive training in patients with aMCI. Furthermore, the combination of functional and structural MRI results will also reveal the underlying mechanisms of the effect of intervention.
C1 [Xing, Yi; Yu, Yueyi; Qiao, Yuchen; Xie, Beijia; Shi, Xinrui; Jia, Jianping; Tang, Yi] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Disorders, Innovat Ctr Neurol Disorders,Dept Neurol, Beijing, Peoples R China.
   [Xing, Yi; Yu, Yueyi; Qiao, Yuchen; Xie, Beijia; Shi, Xinrui; Jia, Jianping; Tang, Yi] Minist Educ Peoples Republ China, Key Lab Neurodegenerat Dis, Beijing, Peoples R China.
   [Zhu, Zude] Jiangsu Normal Univ, Collaborat Innovat Ctr Language Abil, Xuzhou, Jiangsu, Peoples R China.
   [Du, Yifeng] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China.
   [Zhang, Junjian] Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan, Peoples R China.
   [Qu, Qiumin] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Neurol, Xian, Peoples R China.
   [Sun, Li] First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China.
   [Sun, Li] First Hosp Jilin Univ, Neurosci Ctr, Changchun, Peoples R China.
   [Li, Yang] Shanxi Med Univ, Hosp 1, Dept Neurol, Taiyuan, Peoples R China.
   [Guo, Yanjun] Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China.
   [Peng, Guoping] Zhejiang Univ, Affiliated Hosp 1, Dept Neurol, Hangzhou, Peoples R China.
   [Liu, Yong] Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China.
   [Lu, Jie] Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China.
C3 Capital Medical University; Jiangsu Normal University; Shandong First
   Medical University & Shandong Academy of Medical Sciences; Shandong
   University; Wuhan University; Xi'an Jiaotong University; Jilin
   University; Jilin University; Shanxi Medical University; Capital Medical
   University; Zhejiang University; Chinese Academy of Sciences; Institute
   of Automation, CAS; Capital Medical University
RP Tang, Y (corresponding author), Capital Med Univ, Xuanwu Hosp, Innovat Ctr Neurol, 45 Changchun St, Beijing 100053, Peoples R China.; Tang, Y (corresponding author), Capital Med Univ, Xuanwu Hosp, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China.
EM tangyi@xwhosp.org
RI Liu, Yong/F-2682-2011; Lu, Jie/GNW-3367-2022
OI Liu, Yong/0000-0002-1862-3121; Jia, Jianping/0000-0003-4624-0336
FU National Key R&D Program of China [2017YFC1310102, 2019YFC0118200];
   National Natural Science Foundation of China [81671040, 81970996,
   81701044]; Beijing Natural Science Foundation [JQ19024]
FX This study was funded by National Key R&D Program of China
   (2017YFC1310102 and 2019YFC0118200), National Natural Science Foundation
   of China (81671040, 81970996 and 81701044), and Beijing Natural Science
   Foundation (JQ19024).
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NR 38
TC 1
Z9 1
U1 3
U2 24
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2020
VL 75
IS 3
BP 779
EP 787
DI 10.3233/JAD-191314
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA LZ3IG
UT WOS:000541120800009
PM 32333590
DA 2023-08-17
ER

PT J
AU Zhang, K
   Wang, JY
   Peng, GP
   Liu, P
   He, FP
   Zhu, ZD
   Luo, BY
AF Zhang, Kan
   Wang, Junyang
   Peng, Guoping
   Liu, Ping
   He, Fangping
   Zhu, Zude
   Luo, Benyan
TI Effect of cognitive training on episodic memory retrieval in amnestic
   mild cognitive impairment patients: study protocol for a clinical
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE Cognitive control training; MRI; Neural plasticity; aMCI; Clinical
   randomized trial
ID WORKING-MEMORY; OLDER-ADULTS; BRAIN PLASTICITY; WHITE-MATTER; TASK;
   METAANALYSIS; HEALTHY; GAME
AB Background: Mild cognitive impairment (MCI) is a transition state between asymptomatic stage and dementia. Amnestic MCI (aMCI) patients who mainly present with memory deficits are highly likely to progress to Alzheimer's disease (AD). At present, no broadly effective drug therapy is available to prevent the progression from memory deficit to dementia. Cognitive control training, which has transfer effects on multiple cognitive capacities including memory function in healthy old adults, has not yet been applied to aMCI.
   Methods/Design: In this single-center, randomized double-blind placebo-controlled study, 70 aMCI patients will be recruited and randomly assigned to the training and control groups. The intervention is an Internet-based cognitive control training program performed for 30 min daily, five days per week, for 12 consecutive weeks. Neuropsychological assessment and structural and functional magnetic resonance imaging (MRI) will be performed at baseline and outcome. Primary outcomes are changes of episodic memory retrieval function. Secondary outcome measures are neuroplasticity changes measured by functional and structural MRI.
   Discussion: In this study, an Internet-based cognitive control training program is adopted to investigate whether cognitive control training can enhance the retrieval of episodic memory in aMCI patients. The combination of multi-modal MRI and neuropsychological tests could have a good sensitivity in evaluating the effects of cognitive control training and could also uncover the underlying neural underpinning.
C1 [Zhang, Kan; Wang, Junyang; Peng, Guoping; Liu, Ping; He, Fangping; Luo, Benyan] Zhejiang Univ, Dept Neurol, Affiliated Hosp 1, Med Sch, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Zhu, Zude] Jiangsu Normal Univ, Collaborat Innovat Ctr Language Competence, Sch Linguist & Arts, Xuzhou 221116, Jiangsu, Peoples R China.
   [Luo, Benyan] Collaborat Innovat Ctr Brain Sci, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University; Jiangsu Normal University
RP Luo, BY (corresponding author), Zhejiang Univ, Dept Neurol, Affiliated Hosp 1, Med Sch, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.; Zhu, ZD (corresponding author), Jiangsu Normal Univ, Collaborat Innovat Ctr Language Competence, Sch Linguist & Arts, Xuzhou 221116, Jiangsu, Peoples R China.; Luo, BY (corresponding author), Collaborat Innovat Ctr Brain Sci, Hangzhou 310003, Zhejiang, Peoples R China.
EM zhuzude@163.com; luobenyan@zju.edu.cn
FU National Natural Science Foundation of China [31571156]; Ministry of
   Science and Technology of the People's Republic of China
   [2016YFC1306402]; Science Technology Department of Zhejiang Province
   [2017C03011]; Medical Science and Technology Project [2016152769]
FX This experiment is financially supported by the National Natural Science
   Foundation of China (31571156), the Ministry of Science and Technology
   of the People's Republic of China (2016YFC1306402), the Science
   Technology Department of Zhejiang Province (2017C03011), and the Medical
   Science and Technology Project co-founded by Zhejiang Province and the
   Ministry of Health of China (2016152769).
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NR 43
TC 7
Z9 8
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JAN 8
PY 2019
VL 20
AR 26
DI 10.1186/s13063-018-3143-0
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA HX9AZ
UT WOS:000467700200002
PM 30621794
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Park, JH
AF Park, Jin-Hyuck
TI Effects of Spatial Cognitive Training Using Virtual Reality on
   Hippocampal Functions and Prefrontal Cortex Activity in Older Adults
   with Mild Cognitive Impairment
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Article
DE cognition; spatial memory; spatial navigation; prefrontal cortex;
   hippocampus
ID ALZHEIMERS-DISEASE; NEUROPSYCHOLOGICAL PERFORMANCE; ENTORHINAL CORTEX;
   MEMORY; NAVIGATION; TASKS
AB Background: The effects of spatial cognitive training on hippocampal functions and prefrontal cortex (PFC) activity in older adults with mild cognitive impairment (MCI) are unclear yet. The purpose of this study was to investigate the effects of spatial cognitive training using virtual reality (VR) on hippocampal function and PFC activity in older adults with MCI.
   Methods: Fifty older adults with MCI were randomly assigned to the experimental group (EG) performing spatial cognitive training using VR or the control group (CG) receiving computerized spatial cognitive training for a total of 24 sessions. To confirm the effects of spatial cognitive training using VR, the Weschsler Adult Intelligence Scale-Revised Block Design Test (WAIS-BDT) and the Seoul Verbal Learning Test (SVLT) were performed and oxygenated hemoglobin (HbO2) was measured using a functional infrared spectroscopy (fNIRS) system.
   Results: After 24 sessions, the EG showed significantly greater improvements in WAIS-BDT scores (p < .001, eta(2) = .495), the SVLT scores (p < .05, eta(2) = .110), and HbO(2) values (p < .05; c(2) = 0.244), compared to the CG.
   Conclusion: Spatial cognitive training using VR could be clinically effective for improving hippocampal functions and PFC activity in older adults with MCI. Copyright (c) 2022, Taiwan Society of Geriatric Emergency & Critical Care Medicine.
C1 [Park, Jin-Hyuck] Soonchunhyang Univ, Coll Med Sci, Dept Occupat Therapy, Asan, South Korea.
C3 Soonchunhyang University
RP Park, JH (corresponding author), Soonchunhyang Univ, Coll Med Sci, Dept Occupat Therapy, Asan, South Korea.
EM roophy@naver.com
OI Park, Jin-Hyuck/0000-0002-0222-8901
FU National Research Foundation of Korea (NRF) - Ministry of Education
   [2021R1I1A3041487]; Soonchunhyang University Research Fund; National
   Research Foundation of Korea [2021R1I1A3041487] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by Ministry of
   Education (No. 2021R1I1A3041487) .; This work was supported by the
   Soonchunhyang University Research Fund.
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NR 30
TC 1
Z9 1
U1 8
U2 12
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD JUL
PY 2022
VL 16
IS 3
BP 242
EP 246
DI 10.6890/IJGE.202207_16(3).0014
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 3L7YI
UT WOS:000834979200016
DA 2023-08-17
ER

PT J
AU Li, HJ
   Li, JA
   Li, NX
   Li, B
   Wang, PY
   Zhou, T
AF Li, Huijie
   Li, Juan
   Li, Nanxin
   Li, Bing
   Wang, Pengyun
   Zhou, Ting
TI Cognitive intervention for persons with mild cognitive impairment: A
   meta-analysis
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Mild cognitive impairment; Cognitive intervention; Meta-analysis
ID ALZHEIMERS-DISEASE; REHABILITATION PROGRAM; EVERYDAY FUNCTION;
   OLDER-ADULTS; EPISODIC MEMORY; PLASTICITY; PERFORMANCE; MCI; DEMENTIA;
   PEOPLE
AB Cognitive training for persons with mild cognitive impairment (MCI) has become a hot topic. However to date it remains controversial whether persons with MCI can really benefit from cognitive intervention. We aim to further investigate this by using meta-analysis of seventeen clinical studies of cognitive intervention for MCI. The results demonstrate that after training, patients with MCI improve significantly both in overall cognition and overall self-ratings. Specifically, persons with MCI obtain moderate benefits in language, self-rated anxiety and functional ability, and receive mild benefits in episodic memory, semantic memory, executive functioning/working memory, visuo-spatial ability, attention/processing speed, MMSE, self-rated memory problem, quality of life, activities of daily life and self-rated depression. The results also suggest that persons with MCI benefit from the cognitive intervention in the follow-up data. The present meta-analysis demonstrates that cognitive intervention can be a potential efficient method to enhance cognitive and functional abilities in persons with MCI, although the improvements may be domain-specific. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Li, Huijie; Li, Juan; Li, Bing; Wang, Pengyun; Zhou, Ting] Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
   [Li, Nanxin] Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06520 USA.
   [Li, Bing; Wang, Pengyun; Zhou, Ting] Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Psychology, CAS; Yale
   University; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS
RP Li, HJ (corresponding author), Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
EM lihj@psych.ac.cn
RI Li, Nanxin/D-9755-2011; li, bing/GWQ-9617-2022
FU Institute of Psychology, Chinese Academy of Sciences [Y0CX041S01];
   Chinese Academy of Sciences [Y0CX262B01]
FX This study was supported by Project for Young Scientists Fund, Institute
   of Psychology, Chinese Academy of Sciences (Y0CX041S01) and the Special
   Initiating Funds for Winners of Excellent Doctorate Degree Paper and
   Presidential Prizes of Chinese Academy of Sciences (Y0CX262B01).
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NR 78
TC 172
Z9 196
U1 10
U2 111
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD APR
PY 2011
VL 10
IS 2
SI SI
BP 285
EP 296
DI 10.1016/j.arr.2010.11.003
PG 12
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA 744YU
UT WOS:000289131900012
PM 21130185
DA 2023-08-17
ER

PT J
AU Feng, W
   Wang, D
   Tang, L
   Cheng, Y
   Wang, GP
   Hu, GD
   Gong, XL
   Cao, XY
   Jiang, LJ
   Li, CB
AF Feng, Wei
   Wang, Dan
   Tang, Long
   Cheng, Yan
   Wang, Guopu
   Hu, Gengdan
   Gong, Xiaoliang
   Cao, Xinyi
   Jiang, Lijuan
   Li, Chunbo
TI Effects of Different Cognitive Trainings on Amnestic Mild Cognitive
   Impairment in the Elderly: A One-Year Longitudinal Functional Magnetic
   Resonance Imaging (MRI) Study
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Cognitive Therapy; Magnetic Resonance Imaging; Mild Cognitive Impairment
ID OLDER-ADULTS; REGIONAL HOMOGENEITY; ALZHEIMERS-DISEASE; MEMORY;
   INDIVIDUALS; FMRI; MCI; PLASTICITY; COMMUNITY; DEMENTIA
AB Background: Cognitive training has been focused on the interventions of amnestic mild cognitive impairment (aMCI) in recent years, with poor understanding.
   Material/Methods: The study participants with aMCI were screened in a previous intervention trial. Functional magnetic resonance imaging (fMRI) was adopted to investigate effects of single-domain cognitive training (SDCT) and multi-domain cognitive training (MDCT) on aMCI and to explore potential mechanisms.
   Results: There were significant differences in the grey matter volume of the middle frontal gyrus, superior parietal inferior temporal gyrus, fusiform gyrus, and ventral V3 between the MDCT/SDCT group and the control group (P0.05). Regional homogeneity (ReHo) increased significantly in the right and left inferior frontal gyrus as well as in the left and right precentral gyrus after intervention in the MDCT group and the SDCT group. ReHo increased significantly in the right and left lingual gyrus of the MDCT group and the control group. ReHo reduced significantly in the right middle temporal gyrus of the MDCT group but increased significantly in the left middle temporal gyrus in the SDCT group and the control group. The voxel of grey matter in the precuneus was positively related to the language scores on RBANS (Repeatable Battery for the Assessment of Neuropsychological Status), and amygdala, fusiform gyrus, and hippocampus also had a positive relationship with delayed memory scores in RBANS of the MDCT group. In the MDCT group, the attention and reasoning scores were also positively related to the ReHo of middle temporal gyrus.
   Conclusions: Both MDCT and SDCT may improve the aMCI at brain functional and structural levels; however, the MDCT group exhibited higher ReHo values in middle temporal gyrus and superior occipital gyrus. Also, it was confirmed that MDCT leads to better results than SDCT, showing a significant correlation of cognitive functions such as attention, memory, reasoning, and visual-spatial ability.
C1 [Feng, Wei] Shanghai Jiao Tong Univ, Dept Psychol Med, Renji Hosp, Sch Med, Shanghai, Peoples R China.
   [Wang, Dan; Wang, Guopu] Tongji Univ, Dept Phys Educ, Shanghai, Peoples R China.
   [Tang, Long] Univ Shiga Prefecture, Sch Human Cultures, Hikone, Shiga, Japan.
   [Tang, Long] Osaka Univ, Suita, Osaka, Japan.
   [Cheng, Yan] Tongji Univ, Sch Med, Dept Psychiat, Tongji Hosp, Shanghai, Peoples R China.
   [Hu, Gengdan] Tongji Univ, Ctr Psych & Cognit Sci Res, Shanghai, Peoples R China.
   [Hu, Gengdan] Tongji Univ, Dept Psychol, Shanghai, Peoples R China.
   [Gong, Xiaoliang] Tongji Univ, Minist Educ, Key Lab Embedded Syst & Serv Comp, Shanghai, Peoples R China.
   [Cao, Xinyi; Jiang, Lijuan; Li, Chunbo] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China.
   [Cao, Xinyi; Jiang, Lijuan; Li, Chunbo] Shanghai Jiao Tong Univ, Brain Sci & Technol Res Ctr, Shanghai, Peoples R China.
   [Cao, Xinyi; Jiang, Lijuan; Li, Chunbo] Shanghai Jiao Tong Univ, BioX Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Tongji University; University Shiga
   Prefecture; Osaka University; Tongji University; Tongji University;
   Tongji University; Tongji University; Shanghai Jiao Tong University;
   Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Feng, W (corresponding author), Shanghai Jiao Tong Univ, Dept Psychol Med, Renji Hosp, Sch Med, Shanghai, Peoples R China.; Gong, XL (corresponding author), Tongji Univ, Minist Educ, Key Lab Embedded Syst & Serv Comp, Shanghai, Peoples R China.
EM ffww06@163.com; gxllshsh@163.com
RI Cao, Xinyi/G-1047-2013; zhang, jungong/ABE-9041-2021
OI Cao, Xinyi/0000-0002-3476-9833; 
FU National Nature Science Foundation of China [81371505, 81200831,
   30770769]; Nature Science Foundation of Shanghai [17ZR1426400];
   Fundamental Research Funds for the Central Universities [22120170037];
   Top Priority of Clinical Center and Key Discipline Construction in
   Shanghai [2017ZZ02020]; Science and Technology Commission of Shanghai
   Municipality [134119a2501, 13dz2260500]; Humanities and Social Sciences
   Interdisciplinary Project of Tongji University [1430219044, 1430219042];
   Shanghai Municipal Commission of Health and Family Planning [2015ZB0502]
FX This work was supported by the National Nature Science Foundation of
   China (81371505, 81200831, 30770769); the Nature Science Foundation of
   Shanghai (17ZR1426400); the Fundamental Research Funds for the Central
   Universities (22120170037); the Top Priority of Clinical Center and Key
   Discipline Construction in Shanghai(2017ZZ02020); the Science and
   Technology Commission of Shanghai Municipality (134119a2501,
   13dz2260500); Humanities and Social Sciences Interdisciplinary Project
   of Tongji University (1430219044, 1430219042) and Shanghai Municipal
   Commission of Health and Family Planning (2015ZB0502)
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NR 38
TC 11
Z9 11
U1 3
U2 17
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD AUG 8
PY 2018
VL 24
BP 5517
EP 5527
DI 10.12659/MSM.908315
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GP9GN
UT WOS:000441225600003
PM 30089102
OA Green Published, Green Submitted
DA 2023-08-17
ER

PT J
AU Wadley, VG
   Crowe, M
   Marsiske, M
   Cook, SE
   Unverzagt, FW
   Rosenberg, AL
   Rexroth, D
AF Wadley, Virginia G.
   Crowe, Micbael
   Marsiske, Micbael
   Cook, Sarab E.
   Unverzagt, Frederick W.
   Rosenberg, Adrienne L.
   Rexroth, Daniel
TI Changes in everyday function in individuals with psychometrically
   defined mild cognitive impairment in the advanced cognitive training for
   independent and vital elderly study
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE mild cognitive impairment; functional change; ADL; IADL
ID ALZHEIMER-DISEASE; OLDER-ADULTS; DEMENTIA; PERFORMANCE; CONVERSION;
   HEALTH; MEMORY; PREVALENCE; VALIDATION; DRIVERS
AB Objectives: To examine trajectories of change in everyday function for individuals with cognitive deficits suggestive of mild cognitive impairment (MCI).
   Design: Using data from the longitudinal, multisite Advanced Cognitive Training for Independent and Vital Elderly Study allowed for post hoc classification of MCI status at baseline using psychometric definitions for amnestic MCI, nonamnestic MCI, multidomain MCI, and no MCI.
   Setting: Six U.S. cities. PARTICIPANTS: Two thousand eight hundred thirty-two volunteers (mean age 74; 26% African American) living independently, recruited from senior housing, community centers, hospitals, and clinics.
   Measurements: Mixed-effect models examined changes in self-reported activities of daily living and instrumental activities of daily living (IADLs) from the Minimum Data Set Home Care Interview in 2,358 participants over a 3-year period.
   Results: In models for IADL performance, IADL difficulty, and a daily functioning composite, there was a significant time by MCI classification interaction for each MCI subtype, indicating that all MCI groups showed faster rates of decline in everyday function than cognitively normal participants with no MCI.
   Conclusion: Results demonstrate the importance of MCI as a clinical entity that not only predicts progression to dementia, but also predicts functional declines in activities that are key to autonomy and quality of life. MCI classification guidelines should allow for functional changes in MCI, and clinicians should monitor for such changes. Preservation of function may serve as a meaningful outcome for intervention efforts.
C1 Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.
   Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL USA.
   Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46204 USA.
   Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46204 USA.
   Harvard Univ, Hebrew Rehabil Ctr Aged, Boston, MA 02115 USA.
C3 University of Alabama System; University of Alabama Birmingham; State
   University System of Florida; University of Florida; Indiana University
   System; Indiana University-Purdue University Indianapolis; Indiana
   University System; Indiana University-Purdue University Indianapolis;
   Harvard University
RP Wadley, VG (corresponding author), Univ Alabama Birmingham, Dept Med, CH19,218T,1530 3rd Ave, Birmingham, AL 35294 USA.
EM vwadley@uab.edu
RI Cook, Sarah/AAT-1705-2020; Abellan Vidal, Maria Teresa/HLX-5905-2023
OI Marsiske, Michael/0000-0001-5973-2116; Cook, Sarah/0000-0003-0861-3090
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NR 41
TC 77
Z9 79
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD AUG
PY 2007
VL 55
IS 8
BP 1192
EP 1198
DI 10.1111/j.1532-5415.2007.01245.x
PG 7
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 197HE
UT WOS:000248544400005
PM 17661957
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Sukontapol, C
   Kemsen, S
   Chansirikarn, S
   Nakawiro, D
   Kuha, O
   Taemeeyapradit, U
AF Sukontapol, Chalermpong
   Kemsen, Sasithorn
   Chansirikarn, Sirintorn
   Nakawiro, Daochompu
   Kuha, Orawan
   Taemeeyapradit, Unchulee
TI The effectiveness of a cognitive training program in people with mild
   cognitive impairment: A study in urban community
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Cognitive training program; Mild cognitive impairment; Community mental
   health
ID INTERVENTION; STIMULATION; RISK; MCI; AGE
AB Objective: To assess the effectiveness of a cognitive training program on global cognition among people with mild cognitive impairment.
   Methods: In this experimental study, using purposive sampling, 60 participants age 50 years and over who complained of subjective memory impairment were screened in their communities by public health volunteers with the Abbreviated Mental Test. Those with dementia were excluded as well as those with depression, which were screened out by the Thai Geriatric Depression Scale (TGDS-15). Mild cognitive impairment was diagnosed and confirmed by the Montreal Cognitive Assessment (MoCA) and joint agreement between a psychiatrist and a neurologist. The participants were alternately assigned to receive a cognitive training program (intervention group) while the other half received their normal usual therapy (control group). The program involved training of 4 aspects of cognition through 6 sessions; 2 sessions per month for 3 months. The MoCA and TGDS-15 scales were given at baseline and again at week 13, and at months 6 and 9.
   Independent t-tests were used to compare changes in global cognition among the two groups.
   Results: MoCA scores at 9 months were significantly higher than at baseline in both groups. However, the mean difference in intervention group was significantly higher than control group. TGDS-15 scores at 6 months was significantly lower than at baseline among the intervention group but not the control group.
   Conclusion: This cognitive training program helped to improve global cognition and reduce depressive symptoms.
C1 [Sukontapol, Chalermpong] Vachira Phuket Hosp, Phuket 83000, Thailand.
   [Kemsen, Sasithorn; Taemeeyapradit, Unchulee] Songkhlarajanakarindra Psychiat Hosp, Muang Dist 90000, Songkhla, Thailand.
   [Chansirikarn, Sirintorn] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Med, Bangkok 10400, Thailand.
   [Nakawiro, Daochompu] Mahidol Univ, Ramathibodi Hosp, Dept Psychiat, Fac Med, Bangkok 10400, Thailand.
   [Kuha, Orawan] Minist Publ Hlth, Dept Med Serv, Inst Geriatr Med, Muang Dist 11000, Nonthaburi, Thailand.
C3 Mahidol University; Mahidol University
RP Taemeeyapradit, U (corresponding author), Songkhlarajanakarindra Psychiat Hosp, Muang Dist 90000, Songkhla, Thailand.
EM chalermpongs@hotmail.com; sasit3124@hotmail.co.th;
   sirintorn.cha@mahidol.ac.th; daochompu.nak@mahidol.ac.th;
   orawan.k@dms.mail.go.th; unchulee44@gmail.com
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NR 38
TC 1
Z9 1
U1 1
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2018
VL 35
BP 61
EP 66
DI 10.1016/j.ajp.2018.05.019
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA GK7PB
UT WOS:000436398300022
PM 29787954
DA 2023-08-17
ER

PT J
AU Rojas, GJ
   Villar, V
   Iturry, M
   Harris, P
   Serrano, CM
   Herrera, JA
   Allegri, RF
AF Rojas, Galeno J.
   Villar, Veronica
   Iturry, Monica
   Harris, Paula
   Serrano, Cecilia M.
   Herrera, Jorge A.
   Allegri, Ricardo F.
TI Efficacy of a cognitive intervention program in patients with mild
   cognitive impairment
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE cognitive training; cognitive strategies; cognitive intervention;
   controlled trial; placebo; mild cognitive impairment
ID MEMORY; DEMENTIA; ADULTS
AB Background: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Identifying this condition would allow early interventions that may reduce the rate of progression to Alzheimer's disease (AD). We examined the efficacy of a six-month cognitive intervention program (CIP) in patients with MCI and to assess patients' condition at one-year follow-up.
   Methods: Forty-six MCI participants assessed with neuropsychological, neurological, neuropsychiatry, and functional procedures were included in this study and followed up during a year. The sample was randomized into two subgroups: 24 participants (the "trained group") underwent the CIP during six months while 22 (control group) received no treatment. Sixteen participants dropped out of the study. The intervention focused on teaching cognitive strategies, cognitive training, and use of external aids, in sessions of two hours, twice per week for six months. Cognitive and functional measures were used as primary outcome and all were followed up at one year.
   Results: The intervention effect (mean change from baseline) was significant (p < 0.05) on the Mini-Mental State Examination (1.74), the Clinical Dementia Rating Scale (0.14), the Boston Naming Test (2.92), block design (-13.66), matrix reasoning (-3.07), and semantic fluency (-3.071) tasks. Four patients (one trained and three controls) progressed to dementia after one year of follow-up.
   Conclusions: These results suggest that persons with MCI can improve their performance on cognitive and functional measures when provided with early cognitive training and it could persist in a long-term follow-up.
C1 [Rojas, Galeno J.; Villar, Veronica; Iturry, Monica; Serrano, Cecilia M.; Allegri, Ricardo F.] Hosp Zubizarreta GCBA, Dept Neurol, Memory Res Ctr, Buenos Aires, DF, Argentina.
   [Rojas, Galeno J.] British Hosp, Ctr Cognit Neurol, Buenos Aires, DF, Argentina.
   [Harris, Paula; Allegri, Ricardo F.] Serv Cognit Neurol FLENI, Buenos Aires, DF, Argentina.
   [Herrera, Jorge A.] Neurobehav Inst Miami, Miami, FL USA.
C3 Hospital Britanico de Buenos Aires
RP Rojas, GJ (corresponding author), Hosp Britn Buenos Aires, Dept Neurol, Perdriel 74 CP 1280AEB, Buenos Aires, DF, Argentina.
EM grojas@anmat.gov.ar
RI ALLEGRI, RICARDO FRANCISCO/AAY-4898-2021
OI Allegri, Ricardo Francisco/0000-0001-7166-1234
FU Ministry of Health of the city of Buenos Aires, Argentina; CONICET
FX The authors thank Dr Fabian Roman and Dr Andrea Pujol for their helpful
   comments on this paper. This research was jointly supported by a
   grant-in-aid for scientific research (CIS) from the Ministry of Health
   of the city of Buenos Aires, Argentina (VV, CMS, and RFA) and CONICET
   (RFA, and GJR).
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NR 32
TC 45
Z9 52
U1 2
U2 39
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD MAY
PY 2013
VL 25
IS 5
BP 825
EP 831
DI 10.1017/S1041610213000045
PG 7
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 114SD
UT WOS:000316761800014
PM 23414646
DA 2023-08-17
ER

PT J
AU Zhong, DM
   Chen, LY
   Feng, YS
   Song, R
   Huang, LK
   Liu, J
   Zhang, LF
AF Zhong, Dongmei
   Chen, Liangying
   Feng, Yongshen
   Song, Rui
   Huang, Likui
   Liu, Jun
   Zhang, Lifeng
TI Effects of virtual reality cognitive training in individuals with mild
   cognitive impairment: A systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE cognitive training; meta-analysis; mild cognitive impairment; virtual
   reality
ID OLDER-ADULTS; IMPLEMENTATION; RISK
AB Background Virtual reality (VR) is used to improve specific health needs by combining multiple technologies; it is increasingly being used in the medical field, showing satisfactory effects, especially in the management of chronic disease. The aim of this study was to assess the effects of VR cognitive training for individuals with mild cognitive impairment (MCI). Methods Peer-reviewed articles were searched from the PubMed, Embase, Web of Science, the Cochrane Library, Science Direct, and EBSCOhost databases, as well as CNKI, Sinomed, Vip. and Wan Fang, through 23 May 2021. We only included randomized controlled trials (RCTs) enrolling participants with MCI. Results Seventeen RCTs were included, with a total of 744 participants. Evidence of moderate quality showed that VR cognitive training significantly enhanced MCI patients' global cognitive function, as measured by the Montreal Cognitive Assessment (standardized mean difference [SMD] = 0.42; 95% confidence interval [CI], 0.04-0.79; p = 0.03) and executive function, as measured by trail making test A (SMD = -0.58; 95% CI, -0.80 to -0.35; p < 0.001). The meta-analysis indicated that the effects of VR cognitive training on delayed memory, immediate memory, attention and instrumental activities of daily living were not statistically significant (p > 0.05). Conclusion The available data showed that VR cognitive training might be beneficial for improving global cognitive function and executive function in individuals with MCI, although the effects were short term.
C1 [Zhong, Dongmei; Feng, Yongshen; Zhang, Lifeng] Sun Yat Sen Univ, Sch Nursing, 74 Zhongshan Rd 2, Guangzhou, Peoples R China.
   [Chen, Liangying; Song, Rui; Huang, Likui; Liu, Jun] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Neurol, Guangzhou 510080, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Zhang, LF (corresponding author), Sun Yat Sen Univ, Sch Nursing, 74 Zhongshan Rd 2, Guangzhou, Peoples R China.; Liu, J (corresponding author), Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Neurol, Guangzhou 510080, Peoples R China.
EM liujun6@mail.sysu.edu.cn; zhlfeng@mail.sysu.edu.cn
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NR 52
TC 18
Z9 20
U1 5
U2 41
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD DEC
PY 2021
VL 36
IS 12
BP 1829
EP 1847
DI 10.1002/gps.5603
EA AUG 2021
PG 19
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA WQ2NS
UT WOS:000682517300001
PM 34318524
DA 2023-08-17
ER

PT J
AU Park, JH
AF Park, Jin-Hyuck
TI Effects of virtual reality-based spatial cognitive training on
   hippocampal function of older adults with mild cognitive impairment
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE spatial cognition; navigation; virtual reality; cognitive impairment;
   hippocampus
ID ALZHEIMERS-DISEASE; EPISODIC MEMORY; NAVIGATION; DIFFERENTIATION; AGE
AB Background:To date, there is a controversy on effects of cognitive intervention to maintain or improve hippocampal function for older adults with mild cognitive impairment (MCI). Objective:The main objective of this study was to exam effects of virtual reality-based spatial cognitive training (VR-SCT) using VR on hippocampal function of older adults with MCI. Method:Fifty-six older adults with MCI were randomly allocated to the experimental group (EG) that received the VR-SCT or the waitlist control group (CG) for a total of 24 sessions. To investigate effects of the VR-SCT on spatial cognition and episodic memory, the Weschsler Adult Intelligence Scale-Revised Block Design Test (WAIS-BDT) and the Seoul Verbal Learning Test (SVLT) were used. Results:During the sessions, the training performances gradually increased (p < .001). After the intervention, the EG showed significant greater improvements in the WAIS-BDT (p < .001, eta(2) = .667) and recall of the SVLT (p < .05, eta(2) =.094) compared to the CG but in recognition of the SVLT (p > .05, eta(2) =.001). Conclusion:These results suggest that the VR-SCT might be clinically beneficial to enhance spatial cognition and episodic memory of older adults with MCI.
C1 [Park, Jin-Hyuck] Soonchunhyang Univ, Coll Med Sci, Dept Occupat Therapy, Asan, South Korea.
   [Park, Jin-Hyuck] Coll Med Sci, Room 1401,22 Soonchunhyang Ro, Asan 31538, Chungcheongnam, South Korea.
C3 Soonchunhyang University; Soonchunhyang University
RP Park, JH (corresponding author), Coll Med Sci, Room 1401,22 Soonchunhyang Ro, Asan 31538, Chungcheongnam, South Korea.
EM roophy@naver.com
FU Soonchunhyang University Research Fund [20191017]; National Research
   Foundation of Korea - Korea Government (Ministry of Science and ICT,
   MSIT) [2019R1F1A1060719]; National Research Foundation of Korea
   [2019R1F1A1060719] Funding Source: Korea Institute of Science &
   Technology Information (KISTI), National Science & Technology
   Information Service (NTIS)
FX This work was supported by the Soonchunhyang University Research Fund
   (No. 20191017). This work was supported by the National Research
   Foundation of Korea grant funded by the Korea Government (Ministry of
   Science and ICT, MSIT) (No. 2019R1F1A1060719).
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NR 34
TC 6
Z9 6
U1 17
U2 19
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD FEB
PY 2022
VL 34
IS 2
SI SI
BP 157
EP 163
AR PII S1041610220001131
DI 10.1017/S1041610220001131
PG 7
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 6N0MS
UT WOS:000889256200010
PM 32616109
DA 2023-08-17
ER

PT J
AU Zhao, X
   Ji, CF
   Zhang, C
   Huang, C
   Zhou, YY
   Wang, LA
AF Zhao, Xia
   Ji, Caifang
   Zhang, Chen
   Huang, Cheng
   Zhou, Yuanyuan
   Wang, Lina
TI Transferability and sustainability of process-based multi-task adaptive
   cognitive training in community-dwelling older adults with mild
   cognitive impairment: a randomized controlled trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Mild cognitive impairment; Process-based adaptive cognitive training;
   Executive function; Transfer effects
ID EXECUTIVE FUNCTION; WORKING-MEMORY; INTERVENTION; IMPACT; YOUNG
AB Background Cognitive training shows promising effects for improving cognitive domains in individuals with mild cognitive impairment (MCI), including the crucial predictive factor of executive function (EF) for dementia prognosis. Few studies have paid sufficient emphasis on the training-induced effects of cognitive training programs, particularly with regards to targeting EF. A process-based multi-task adaptive cognitive training (P-bM-tACT) program targeting EF is required to examine direct, transfer, and sustainability effects in older adults with MCI.
   Objective This study aimed to evaluate the direct effects of a P-bM-tACT program on EF, the transfer effects on untrained cognitive domains, and further explore the sustainability of training gains for older adults with MCI in the community.
   Methods In a single-blind, randomized controlled trial, 92 participants with MCI were randomly assigned to either the intervention group, participating in a P-bM-tACT program (3 training sessions/week, 60 min/session for 10 weeks) or the wait-list control group, accepting a health education program on MCI (1 education session/ twice a week, 40-60 min/session for 10 weeks). The direct and transfer effects of the P-bM-tACT program were assessed at baseline, immediately after 10 weeks of training, and the 3-month follow-up. Repeated measures analysis of variance and a simple effect test were used to compare the direct and transfer effects over the 3-time points between the two groups.
   Results The P-bM-tACT program yielded a greater benefit of direct and transfer effects in the intervention group participants than in the wait-list control group. Combined with the results of simple effect tests, the direct and transfer effects of participants in the intervention group significantly increased immediately after 10 weeks of training compared to the baseline (F = 14.702 similar to 62.905, p < 0.05), and these effects were maintained at the 3-month follow-up (F = 19.595 similar to 122.22, p < 0.05). Besides, the acceptability of the cognitive training program was established with a high adherence rate of 83.4%.
   Conclusions The P-bM-tACT program exerted positive direct and transfer effects on the improvement of cognitive function, and these effects were sustained for 3 months. The findings provided a viable and potential approach to improving cognitive function in older adults with MCI in the community.
C1 [Zhao, Xia; Ji, Caifang] Suzhou Guangji Hosp, Dept Geriatr Psychiat, Suzhou, Jiangsu, Peoples R China.
   [Zhao, Xia; Huang, Cheng; Wang, Lina] Huzhou Univ, Sch Med, Huzhou, Zhejiang, Peoples R China.
   [Zhang, Chen] Community Hlth Serv Ctr, Dept Gen Med, Binhu St, Hangzhou, Zhejiang, Peoples R China.
   [Zhou, Yuanyuan] Jiangsu Coll Nursing, Sch Nursing, Huaian, Jiangsu, Peoples R China.
C3 Huzhou University
RP Wang, LA (corresponding author), Huzhou Univ, Sch Med, Huzhou, Zhejiang, Peoples R China.
EM aring2000@163.com
FU National Natural Science Foundation [72174061, 71704053]; Suzhou Youth
   Science and Technology Project [KJXW2020051]; Suzhou Science and
   Technology Development Project [SYSD2020164]; Suzhou medical key support
   disciplines [SZFCXK202103]; Zhejiang Health and Science and Technology
   Project [2022KY370]
FX <STRONG> </STRONG>This work was supported by the National Natural
   Science Foundation (No. 72174061, NO.71704053); Suzhou Youth Science and
   Technology Project (NO. KJXW2020051); Suzhou Science and Technology
   Development Project (NO. SYSD2020164); Suzhou medical key support
   disciplines (NO.SZFCXK202103) and Zhejiang Health and Science and
   Technology Project (NO.2022KY370). The funding organizations did not
   participate in the design of the study, data analysis, and manuscript
   formation.
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NR 62
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JUN 12
PY 2023
VL 23
IS 1
AR 418
DI 10.1186/s12888-023-04917-3
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA J1UZ3
UT WOS:001007544900002
PM 37308857
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Lipardo, DS
   Tsang, WWN
AF Lipardo, Donald S.
   Tsang, William W. N.
TI Effects of combined physical and cognitive training on fall prevention
   and risk reduction in older persons with mild cognitive impairment: a
   randomized controlled study
SO CLINICAL REHABILITATION
LA English
DT Article
DE Mild cognitive impairment; older persons; fall incidence; risk of falls
ID CONTROLLED-TRIAL; ADULTS; EXERCISE; PEOPLE; INTERVENTIONS; PROGRAMS;
   BALANCE; GAIT
AB Objective:
   The aim of this study is to investigate the effects of combined physical and cognitive training on fall rate and risks of falling in older adults with mild cognitive impairment.
   Design:
   The design of this study was an assessor-blinded, randomized controlled trial.
   Setting:
   The setting for this study is the community from Manila, Philippines.
   Subjects:
   In total, 92 community-dwelling older persons with mild cognitive impairment (aged 60-83) were randomly allocated to three intervention groups and one waitlist control group.
   Interventions:
   The physical training, cognitive training, and combined physical and cognitive training intervention programs were delivered for 60 to 90 minutes, one to three times per week for 12 weeks with six-month follow-up.
   Main measures:
   Participants were assessed at baseline, 12 weeks after baseline, and 36 weeks after baseline for fall incidence, overall fall risk, dynamic balance, walking speed, and lower limb strength.
   Results:
   No significant difference was observed across time and groups on fall incidence rate at 12 weeks (P = 0.152) and at 36 weeks (P = 0.954). The groups did not statistically differ in other measures except for a significant improvement in dynamic balance based on Timed Up and Go Test in the combined physical and cognitive training group (9.0 seconds with P = 0.001) and in the cognitive training alone group (8.6 seconds with P = 0.012) compared to waitlist group (11.1 seconds) at 36 weeks.
   Conclusion:
   There was no significant difference among groups on fall rate and risks of falling post-intervention. Dynamic balance was improved with combined physical and cognitive training and cognitive training alone. Further research with a larger sample size is needed to establish whether or not the interventions are effective.
C1 [Lipardo, Donald S.; Tsang, William W. N.] Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China.
   [Lipardo, Donald S.] Univ Santo Tomas, Dept Phys Therapy, Coll Rehabil Sci, Manila, Philippines.
   [Tsang, William W. N.] Open Univ Hong Kong, Sch Nursing & Hlth Studies, Dept Physiotherapy, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University; University of Santo Tomas; Hong Kong
   Metropolitan University
RP Tsang, WWN (corresponding author), Open Univ Hong Kong, Sch Nursing & Hlth Studies, Dept Physiotherapy, Kowloon, Hong Kong, Peoples R China.
EM wntsang@ouhk.edu.hk
RI Lipardo, Donald/AAV-3757-2020; Lipardo, Donald/N-3982-2015
OI Lipardo, Donald/0000-0001-8094-579X
FU Research Studentship Scholarship-Associated Money of the Hong Kong
   Polytechnic University
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research did not receive any specific grant from funding agencies in the
   public, commercial, or not-for-profit sectors. Financial support came
   from the Research Studentship Scholarship-Associated Money of the Hong
   Kong Polytechnic University.
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NR 26
TC 18
Z9 19
U1 2
U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-2155
EI 1477-0873
J9 CLIN REHABIL
JI Clin. Rehabil.
PD JUN
PY 2020
VL 34
IS 6
BP 773
EP 782
AR 0269215520918352
DI 10.1177/0269215520918352
EA MAY 2020
PG 10
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA LT2SD
UT WOS:000533110400001
PM 32380917
DA 2023-08-17
ER

PT J
AU Scheerbaum, P
   Book, S
   Jank, M
   Hanslian, E
   DellO'ro, M
   Schneider, J
   Scheuermann, JS
   Bosl, S
   Jeitler, M
   Kessler, C
   Graessel, E
AF Scheerbaum, Petra
   Book, Stephanie
   Jank, Michael
   Hanslian, Etienne
   DellO'ro, Melanie
   Schneider, Julia
   Scheuermann, Julia-Sophia
   Boesl, Sophia
   Jeitler, Michael
   Kessler, Christian
   Graessel, Elmar
TI Computerised cognitive training tools and online nutritional group
   counselling for people with mild cognitive impairment: study protocol of
   a completely digital, randomised, controlled trial
SO BMJ OPEN
LA English
DT Article
ID MINI-MENTAL-STATE; DIETARY PATTERNS; OLDER-ADULTS; HIGHER RISK;
   DEMENTIA; MOCA; INFLAMMATION; INDIVIDUALS; CONSUMPTION; VALIDATION
AB Introduction People with mild cognitive impairment (MCI) are at increased risk of decreasing cognitive functioning. Computerised cognitive training (CCT) and nutrition have been shown to improve the cognitive capacities of people with MCI. For each variable, we developed two kinds of interventions specialised for people with MCI (CCT: 'individualised' CCT; nutrition: a whole-food, plant-based diet). Additionally, there are two kinds of active control measures (CCT: 'basic' CCT; nutrition: a healthy diet following the current guidelines of the German Nutrition Society). The aim of this study is to investigate the effects of the two interventions on cognition in people with MCI in a 2x2 randomised controlled trial with German participants.
   Methods and analysis Participants will be community-dwelling individuals with a psychometric diagnosis of MCI based on the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination. With N=200, effects with an effect size of f >= 0.24 (comparable to Cohen's d >= 0.48) can be detected. Screening, baseline, t6 and t12 testing will be conducted via a videoconferencing assessment, telephone, and online survey. Participants will be randomly allocated to one of four groups and will receive a combination of CCT and online nutritional counselling. The CCT can be carried out independently at home on a computer, laptop, or tablet. Nutrition counselling includes 12 online group sessions every fortnight for 1.5 hours. The treatment phase is 6 months with follow-ups after six and 12 months after baseline.
   Ethics and dissemination All procedures were approved by the Friedrich-Alexander-Universitat Erlangen-Nurnberg Ethics Committee (Ref. 21-318-1-B). Written informed consent will be obtained from all participants. Results will be published in peer-reviewed scientific journals, conference presentations.
C1 [Scheerbaum, Petra; Book, Stephanie; Jank, Michael; Scheuermann, Julia-Sophia; Boesl, Sophia; Graessel, Elmar] Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Ctr Hlth Serv Res Med, Dept Psychiat & Psychotherapy, Erlangen, Germany.
   [Jank, Michael] Genesis Mediware GmbH, Hersbruck, Germany.
   [Hanslian, Etienne; DellO'ro, Melanie; Schneider, Julia; Jeitler, Michael; Kessler, Christian] Charite, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
C3 University of Erlangen Nuremberg; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Scheerbaum, P (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Ctr Hlth Serv Res Med, Dept Psychiat & Psychotherapy, Erlangen, Germany.
EM petra.scheerbaum@uk-erlangen.de
RI Hanslian, Etienne/HJI-1501-2023
OI Hanslian, Etienne/0000-0002-8683-5011; Kessler,
   Christian/0000-0001-7794-8375; Scheerbaum, Petra/0000-0001-7794-1165;
   Scheuermann, Julia-Sophia/0000-0001-5764-346X; Jeitler,
   Michael/0000-0003-3277-9090
FU Karl and Veronica Carstens--Stiftung [45 276]
FX This work is supported by the Karl and Veronica Carstens--Stiftung (Am
   Deimelsberg 36, 45 276 Essen).
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NR 85
TC 0
Z9 1
U1 1
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUL
PY 2022
VL 12
IS 7
AR e060473
DI 10.1136/bmjopen-2021-060473
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2Q8VO
UT WOS:000820695600005
PM 35777882
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Chandler, MJ
   Parks, AC
   Marsiske, M
   Rotblatt, LJ
   Smith, GE
AF Chandler, M. J.
   Parks, A. C.
   Marsiske, M.
   Rotblatt, L. J.
   Smith, G. E.
TI Cognitive interventions in Mild Cognitive Impairment: A systematic
   review and meta-analysis
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
RI Parks, Andrew/T-3480-2019
NR 0
TC 0
Z9 0
U1 0
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PY 2017
VL 31
IS 4
MA 2
BP 709
EP 709
PG 1
WC Psychology, Clinical; Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA ES6HB
UT WOS:000399646200042
DA 2023-08-17
ER

PT J
AU Loetscher, T
AF Loetscher, Tobias
TI Cognitive training interventions for dementia and mild cognitive
   impairment in Parkinson's disease - A cochrane review summary with
   commentary
SO NEUROREHABILITATION
LA English
DT Review
DE Parkinson's disease; cognitive training; training; dementia; mild
   cognitive impairment
AB BACKGROUND: The majority of people living with Parkinson's disease will develop impairments in cognition. These impairments are associated with a reduced quality of life.
   OBJECTIVE: The Cochrane Review aimed to investigate whether cognitive training improves cognition in people with Parkinson's disease and mild cognitive impairments or dementia.
   METHODS: A Cochrane Review by Orgeta et al. was summarized with comments.
   RESULTS: The review included seven studies with a total of 225 participants. There was no evidence for improvements in global cognition when cognitive training was compared to control conditions. Observed improvements in attention and verbal memory measures after cognitive training could not be confirmed in a subsequent sensitivity analysis. There was no evidence for benefits in other cognitive domains or quality of life measures. The certainty of the evidence was low for all comparisons.
   CONCLUSIONS: The effectiveness of cognitive training for people with Parkinson's disease and cognitive impairments remains inconclusive. There is a pressing need for adequately powered trials with higher methodological quality.
C1 [Loetscher, Tobias] Univ South Australia, Sch Psychol Social Work & Social Policy, Cognit Ageing & Impairment Neurosci Lab, Adelaide, SA, Australia.
C3 University of South Australia
RP Loetscher, T (corresponding author), Univ South Australia, Sch Psychol Social Work & Social Policy, Cognit Ageing & Impairment Neurosci Lab, Adelaide, SA, Australia.
EM tobias.loetscher@unisa.edu.au
OI Loetscher, Tobias/0000-0003-1967-2926
FU National Health and Medical Research Council (NHMRC) Dementia Research
   Leadership Fellowship [GNT1136269]
FX The author thanks Cochrane Rehabilitation and Cochrane Dementia and
   Cognitive Improvement Group for reviewing the contents of the Cochrane
   Corner. He was supported by a National Health and Medical Research
   Council (NHMRC) Dementia Research Leadership Fellowship (GNT1136269).
CR Gavelin HM, 2020, NEUROPSYCHOL REV, V30, P167, DOI 10.1007/s11065-020-09434-8
   Hill NTM, 2017, AM J PSYCHIAT, V174, P329, DOI 10.1176/appi.ajp.2016.16030360
   Leung IHK, 2015, NEUROLOGY, V85, P1843, DOI 10.1212/WNL.0000000000002145
   Orgeta V, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011961.pub2
   Walton CC, 2017, NEUROREHAB NEURAL RE, V31, P207, DOI 10.1177/1545968316680489
NR 5
TC 2
Z9 2
U1 4
U2 21
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1053-8135
EI 1878-6448
J9 NEUROREHABILITATION
JI Neurorehabilitation
PY 2021
VL 48
IS 3
BP 385
EP 387
DI 10.3233/NRE-218001
PG 3
WC Clinical Neurology; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Rehabilitation
GA RX5OB
UT WOS:000647271700015
PM 33780379
OA Bronze, Green Accepted
DA 2023-08-17
ER

PT J
AU Kanemaru, A
   Kato, T
   Sugawara, Y
   Kawaji, Y
   Hiraoka, T
   Honda, T
   Nagajima, R
   Makita, A
   Itakura, A
   Yamazaki, R
   Ota, T
AF Kanemaru, A.
   Kato, T.
   Sugawara, Y.
   Kawaji, Y.
   Hiraoka, T.
   Honda, T.
   Nagajima, R.
   Makita, A.
   Itakura, A.
   Yamazaki, R.
   Ota, T.
TI The effects of the intervention using physical exercise and cognitive
   training on the mental status of the elderly with mild cognitive
   impairment or mild dementia
SO JOURNAL OF THE NEUROLOGICAL SCIENCES
LA English
DT Meeting Abstract
CT 23rd World Congress of Neurology (WCN)
CY SEP 16-21, 2017
CL Kyoto, JAPAN
SP World Federat Neurol
C1 [Kanemaru, A.; Kato, T.; Sugawara, Y.; Kawaji, Y.; Hiraoka, T.; Honda, T.; Nagajima, R.; Makita, A.; Itakura, A.; Ota, T.] Tokyo Metropolitan Geriatr Hosp, Rehabil, Itabashi Ku, Tokyo, Japan.
   [Yamazaki, R.] Japan Inst Leisure Serv & Educ Co, Tokyo, Japan.
NR 0
TC 0
Z9 0
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-510X
EI 1878-5883
J9 J NEUROL SCI
JI J. Neurol. Sci.
PD OCT 15
PY 2017
VL 381
SU S
MA 1846
BP 667
EP 667
DI 10.1016/j.jns.2017.08.1876
PG 1
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology
GA FZ2YT
UT WOS:000427450302298
DA 2023-08-17
ER

PT J
AU Hampstead, BM
   Sathian, K
   Moore, AB
   Nalisnick, C
   Stringer, AY
AF Hampstead, Benjamin M.
   Sathian, K.
   Moore, Anna Bacon
   Nalisnick, Carrie
   Stringer, Anthony Y.
TI Explicit memory training leads to improved memory for face-name pairs in
   patients with mild cognitive impairment: Results of a pilot
   investigation
SO JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the International-Neuropsychological-Society
CY FEB09, 2008
CL Waikoloa, HI
SP Int Neuropsychol Soc
DE cognitive rehabilitation; Alzheimer's disease; dementia; aging;
   associative memory; multi-domain MCI
ID ALZHEIMERS-DISEASE; OLDER-ADULTS; REHABILITATION; ACTIVATION; DEMENTIA
AB Relatively few studies have examined the use of cognitive rehabilitation in patients with mild cognitive impairment (MCI), largely due to the assumption that training will not improve functioning in patients with progressive conditions. Face-name association, an ecologically valid task, is both dependent on the explicit memory system and difficult for MCI patients. During three hour-long sessions, eight patients diagnosed with MCI were trained in the use of explicit memory strategies with 45 face-name pairs. For each pair, they were taught to visually identify a facial feature, link a phonological cue to that feature, and recall the associated name. There was significant improvement in recognition accuracy, along with faster reaction times, for trained face-name pairs. Improved accuracy persisted when tested one month after training. Significant, but less, improvement was also found on untrained stimuli, raising the possibility of generalization of training strategies. preliminary results suggest strategy-based cognitive rehabilitation may be beneficial in patients with MCI, though these results must be replicated with a control group to rule out practice effects.
C1 [Hampstead, Benjamin M.; Moore, Anna Bacon; Stringer, Anthony Y.] Emory Univ, Dept Rehabil Med, Atlanta, GA 30322 USA.
   [Hampstead, Benjamin M.; Sathian, K.; Moore, Anna Bacon; Nalisnick, Carrie] Atlanta VAMC, Rehabil R&D Ctr Excellence, Decatur, GA USA.
   [Sathian, K.; Nalisnick, Carrie] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA.
   [Sathian, K.; Stringer, Anthony Y.] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA.
C3 Emory University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; Emory University;
   Emory University
RP Hampstead, BM (corresponding author), Emory Univ, Dept Rehabil Med, 1441 Clifton Rd NE,Room 150, Atlanta, GA 30322 USA.
EM bhampst@emory.edu
OI Sathian, Krish/0000-0001-9495-2499; Hampstead,
   Benjamin/0000-0003-2717-6375
FU NEI NIH HHS [K24 EY017332] Funding Source: Medline
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NR 25
TC 72
Z9 74
U1 0
U2 28
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1355-6177
EI 1469-7661
J9 J INT NEUROPSYCH SOC
JI J. Int. Neuropsychol. Soc.
PD SEP
PY 2008
VL 14
IS 5
BP 883
EP 889
DI 10.1017/S1355617708081009
PG 7
WC Clinical Neurology; Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA 354DZ
UT WOS:000259620400019
PM 18764984
OA Bronze
DA 2023-08-17
ER

PT J
AU Casoli, T
   Giuli, C
   Balietti, M
   Giorgetti, B
   Solazzi, M
   Fattoretti, P
AF Casoli, Tiziana
   Giuli, Cinzia
   Balietti, Marta
   Giorgetti, Belinda
   Solazzi, Moreno
   Fattoretti, Patrizia
TI Effect of Cognitive Training on the Expression of Brain-Derived
   Neurotrophic Factor in Lymphocytes of Mild Cognitive Impairment Patients
SO REJUVENATION RESEARCH
LA English
DT Article
ID ALZHEIMERS-DISEASE; SERUM BDNF; DEMENTIA; PLASTICITY; EXERCISE
AB To identify biomarkers associated with cognitive stimulation of mild cognitive impairment (MCI) patients, we performed quantitative real-time reverse transcriptase polymerase chain reaction for brain-derived neurotrophic factor (BDNF) mRNA in peripheral lymphocytes of MCI and healthy subjects undergoing a multi-component cognitive training (CT) program. CT determined a significant decrease of BDNF mRNA levels in MCI (fold change=0.31) as compared to healthy subjects (fold change=0.86). It has been reported that in MCI there is an increase of BDNF serum levels, and our findings could indicate a positive effect of CT in restoring pre-disease levels of expression.
C1 [Casoli, Tiziana; Balietti, Marta; Giorgetti, Belinda; Solazzi, Moreno; Fattoretti, Patrizia] INRCA IRCCS, Ctr Neurobiol Aging, I-60121 Ancona, Italy.
   [Balietti, Marta; Solazzi, Moreno; Fattoretti, Patrizia] INRCA IRCCS, Cellular Bioenerget Lab, I-60121 Ancona, Italy.
   [Giuli, Cinzia] INRCA IRCCS Hosp, Unit Geriatr, Fermo, Italy.
RP Casoli, T (corresponding author), INRCA IRCCS, Ctr Neurobiol Aging, Via Birarelli 8, I-60121 Ancona, Italy.
EM t.casoli@inrca.it
RI Fattoretti, Patrizia/A-8152-2011; Giuli, Cinzia/K-1172-2016; Balietti,
   Marta/AAD-9098-2020; Casoli, Tiziana/AAC-2787-2019
OI Giuli, Cinzia/0000-0001-8826-2467; Balietti, Marta/0000-0002-3123-7903;
   Casoli, Tiziana/0000-0002-0512-2934; Fattoretti,
   Patrizia/0000-0003-1998-0080
FU Italian Ministry of Health and Marche Region under "My Mind Project"
   [154/GR-2009-1584108]
FX This work was funded by Italian Ministry of Health and Marche Region
   under "My Mind Project" (code number 154/GR-2009-1584108). The authors
   would like to thank Laura Costarelli, Robertina Giacconi, and Nazzarena
   Gasparini for their contribution in laboratory procedures.
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NR 19
TC 11
Z9 13
U1 1
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD APR 1
PY 2014
VL 17
IS 2
BP 235
EP 238
DI 10.1089/rej.2013.1516
PG 4
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AF2LM
UT WOS:000334543600029
PM 24127698
DA 2023-08-17
ER

PT J
AU Hong, YJ
   Jang, EH
   Hwang, J
   Roh, JH
   Lee, JH
AF Hong, Yun Jeong
   Jang, Eun Hye
   Hwang, Jihye
   Roh, Jee Hoon
   Lee, Jae-Hong
TI The Efficacy of Cognitive Intervention Programs for Mild Cognitive
   Impairment: A Systematic Review
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Article
DE Alzheimer's disease; cognitive intervention; cognitive outcome;
   functional brain imaging; mild cognitive impairment; progression
ID LIST CONTROLLED-TRIAL; FACE-NAME PAIRS; ALZHEIMERS-DISEASE; SIGNIFICANT
   OTHERS; REHABILITATION PROGRAM; GROUP-THERAPY; OLDER-ADULTS; BRAIN
   METABOLISM; FUTURE-RESEARCH; MEMORY
AB Mild cognitive impairment (MCI) describes a transitional state in progression from normal aging to dementia, especially Alzheimer's disease (AD). Currently, there is no effective pharmacological treatment that offers a long-term beneficial effect to delay the progression to dementia. There is growing evidence that supports an important role of non-pharmacological cognitive interventions. Therefore, it is warranted to clarify the distinct forms of cognitive interventions and their effects based on previous clinical trials. We aimed to provide a review of clinical trials of non-pharmacological cognitive interventions for MCI and to address the characteristics of the study patients, cognitive intervention programs and short-term / long-term benefits of the interventions. A total of 32 articles were identified according to the inclusion criteria. The results showed positive effects for both objective and subjective outcome variables, and these effects persisted from 1 month up to 5 years. Although many of the positive effects were related to improvement in trained tasks, alterations in neuroimaging and the transfer effects shown by some studies are encouraging. Future research in this area requires a larger sample size with a wider spectrum of MCI, more instructive outcome measures and a longer follow up duration.
C1 [Hong, Yun Jeong; Jang, Eun Hye; Hwang, Jihye; Roh, Jee Hoon; Lee, Jae-Hong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Lee, JH (corresponding author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, 88 Olymp Ro 43 Gil, Seoul 138736, South Korea.
EM jhlee@amc.seoul.kr
RI JH, Roh/F-4078-2014
OI JH, Roh/0000-0002-3243-0529; Hong, Yun Jeong/0000-0002-4996-4981
FU Korea Healthcare Technology R&D Project, Ministry of Health and Welfare,
   Republic of Korea [HI10C2020]; Korea Health Industry Development
   Institute Grant [HI14C3319]; Korea Institute of Science and Technology
   Institutional Program [2E24242-13-110]; Asan Institute for Life Sciences
   [2015-590]
FX This work was supported by a grant from the Korea Healthcare Technology
   R&D Project, Ministry of Health and Welfare, Republic of Korea (no.
   HI10C2020), the Korea Health Industry Development Institute Grant
   (HI14C3319), the Korea Institute of Science and Technology Institutional
   Program (2E24242-13-110), and a grant (2015-590) from the Asan Institute
   for Life Sciences (to J.H. Roh).
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NR 67
TC 15
Z9 17
U1 2
U2 36
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PY 2015
VL 12
IS 6
BP 527
EP 542
DI 10.2174/1567205012666150530201636
PG 16
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA CN3CZ
UT WOS:000358302800005
PM 26027815
DA 2023-08-17
ER

PT J
AU He, WB
   Wang, M
   Jiang, LL
   Li, MX
   Han, XM
AF He, Wenbo
   Wang, Meng
   Jiang, Lili
   Li, Meixuan
   Han, Xuemei
TI Cognitive interventions for mild cognitive impairment and dementia: An
   overview of systematic reviews
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Cognitive interventions; Mild cognitive impairment; Dementia; Overview
ID ALZHEIMERS-DISEASE; METAANALYSIS; OUTCOMES; PEOPLE; IMPACT
AB Purpose: Conducting an overview of systematic reviews (SRs)/Meta analyses (MAs) to assess the effectiveness of cognitive interventions on participants with mild cognitive impairment (MCI) or dementia and evaluate the methodological quality of SRs/MAs.
   Methods: PubMed, EMBASE, Cochrane library, Web of science, China National Knowledge Infrastructure (CNKI) and Chinese Biomedical Databases (CBM) were systematically searched from inception to January 1, 2019 to identify SRs/MAs. Three reviewers independently screened the articles, extracted data and assessed the quality of the included studies according to the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2), the Grading of Recommendations Assessment Development and Evaluation (GRADE) was used to evaluate the quality of evidence.
   Results: A total of 22 reviews were included. New meta-analyses (36 RCTs) showed that cognitive interventions were more effective than routine therapies for the alleviation of MCI and dementia symptoms (SMD: 0.62; 95%CI: 0.47, 0.78; I-2 = 53.9%). The results of AMSTAR-2 showed that the methodological quality of most included studies was critically low, and two reviews were low quality. The lowest score was item 10, none of reviews reported on the sources of funding for the included studies. Followed by the "provide a list of excluded studies and justify the exclusions" item with only one (4.5%) reviews conforming to this item. Results of GRADE manifested that moderate quality evidence was provided in 11 reviews (39.3%), 12 (42.9%) were low quality and 5 (17.8%) were very low.
   Conclusion: The present SRs/MAs indicated that persons with MCI or dementia could benefit from cognitive interventions. Future trial designs should focus on measuring changes in individual specific cognitive functions. More high-quality evidence is needed to further determine the effectiveness of cognitive interventions.
C1 [He, Wenbo; Wang, Meng; Jiang, Lili; Li, Meixuan; Han, Xuemei] Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China.
   [Li, Meixuan] Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China.
   [Li, Meixuan] Evidence Based Social Sci Res Ctr, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Han, XM (corresponding author), Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China.
EM xmhan123@163.com
OI He, Wenbo/0000-0001-6243-1496
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NR 39
TC 9
Z9 9
U1 3
U2 26
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD DEC
PY 2019
VL 47
AR 102199
DI 10.1016/j.ctim.2019.102199
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA JU4JI
UT WOS:000501643500009
PM 31780033
DA 2023-08-17
ER

PT J
AU Hassandra, M
   Galanis, E
   Hatzigeorgiadis, A
   Goudas, M
   Mouzakidis, C
   Karathanasi, EM
   Petridou, N
   Tsolaki, M
   Zikas, P
   Evangelou, G
   Papagiannakis, G
   Bellis, G
   Kokkotis, C
   Panagiotopoulos, SR
   Giakas, G
   Theodorakis, Y
AF Hassandra, Mary
   Galanis, Evangelos
   Hatzigeorgiadis, Antonis
   Goudas, Marios
   Mouzakidis, Christos
   Karathanasi, Eleni Maria
   Petridou, Niki
   Tsolaki, Magda
   Zikas, Paul
   Evangelou, Giannis
   Papagiannakis, George
   Bellis, George
   Kokkotis, Christos
   Panagiotopoulos, Spyridon Rafail
   Giakas, Giannis
   Theodorakis, Yannis
TI A Virtual Reality App for Physical and Cognitive Training of Older
   People With Mild Cognitive Impairment: Mixed Methods Feasibility Study
SO JMIR SERIOUS GAMES
LA English
DT Article
DE virtual reality; elderly; mild cognitive impairment; combined physical
   and cognitive function; dual task
ID SELF-DETERMINATION THEORY; DUAL-TASK GAIT; EXERCISE; DEMENTIA;
   MOTIVATION; INTERVENTION; SYMPTOMS; DISEASE; ADULTS; MCI
AB Background: Therapeutic virtual reality (VR) has emerged as an effective treatment modality for cognitive and physical training in people with mild cognitive impairment (MCI). However, to replace existing nonpharmaceutical treatment training protocols, VR platforms need significant improvement if they are to appeal to older people with symptoms of cognitive decline and meet their specific needs.
   Objective: This study aims to design and test the acceptability, usability, and tolerability of an immersive VR platform that allows older people with MCI symptoms to simultaneously practice physical and cognitive skills on a dual task.
   Methods: On the basis of interviews with 20 older people with MCI symptoms (15 females; mean age 76.25, SD 5.03 years) and inputs from their health care providers (formative study VR1), an interdisciplinary group of experts developed a VR system called VRADA (VR Exercise App for Dementia and Alzheimer's Patients). Using an identical training protocol, the VRADA system was first tested with a group of 30 university students (16 females; mean age 20.86, SD 1.17 years) and then with 27 older people (19 females; mean age 73.22, SD 9.26 years) who had been diagnosed with MCI (feasibility studies VR2a and VR2b). Those in the latter group attended two Hellenic Association Day Care Centers for Alzheimer's Disease and Related Disorders. Participants in both groups were asked to perform a dual task training protocol that combined physical and cognitive exercises in two different training conditions. In condition A, participants performed a cycling task in a lab environment while being asked by the researcher to perform oral math calculations (single-digit additions and subtractions). In condition B, participants performed a cycling task in the virtual environment while performing calculations that appeared within the VR app. Participants in both groups were assessed in the same way; this included questionnaires and semistructured interviews immediately after the experiment to capture perceptions of acceptability, usability, and tolerability, and to determine which of the two training conditions each participant preferred.
   Results: Participants in both groups showed a significant preference for the VR condition (students: mean 0.66, SD 0.41, t(29)=8.74, P<.001; patients with MCI: mean 0.72, SD 0.51, t(26)=7.36, P<.001), as well as high acceptance scores for intended future use, attitude toward VR training, and enjoyment. System usability scale scores (82.66 for the students and 77.96 for the older group) were well above the acceptability threshold (75/100). The perceived adverse effects were minimal, indicating a satisfactory tolerability.
   Conclusions: The findings suggest that VRADA is an acceptable, usable, and tolerable system for physical and cognitive training of older people with MCI and university students. Randomized controlled trial studies are needed to assess the efficacy of VRADA as a tool to promote physical and cognitive health in patients with MCI.
C1 [Hassandra, Mary; Galanis, Evangelos; Hatzigeorgiadis, Antonis; Goudas, Marios; Kokkotis, Christos; Giakas, Giannis; Theodorakis, Yannis] Univ Thessaly, Sch Phys Educ Sport Sci & Dietet, Dept Phys Educ & Sport Sci, Trikala, Greece.
   [Mouzakidis, Christos; Karathanasi, Eleni Maria; Petridou, Niki; Tsolaki, Magda] Alzheimer Hellas, Greek Assoc Alzheimers Dis Related Disorders, Thessaloniki, Makedonia, Greece.
   [Tsolaki, Magda] Aristotle Univ Thessaloniki, Sch Med, Dept Neurol 1, Fac Hlth Sci, Thessaloniki, Makedonia, Greece.
   [Zikas, Paul; Evangelou, Giannis; Papagiannakis, George] ORamaVR SA, Sci & Technol Pk Crete, Iraklion, Crete, Greece.
   [Papagiannakis, George] Univ Crete, Inst Comp Sci, Fdn Res & Technol Hellas FORTH, Iraklion, Crete, Greece.
   [Bellis, George; Kokkotis, Christos; Panagiotopoulos, Spyridon Rafail] Biomech Solut Engn BME, Kardhitsa, Greece.
C3 University of Thessaly; Aristotle University of Thessaloniki; University
   of Crete
RP Hassandra, M (corresponding author), Univ Thessaly, Sch Phys Educ Sport Sci & Dietet, Dept Phys Educ & Sport Sci, Karies 42100, Trikala, Greece.
EM mxasad@uth.gr
RI Theodorakis, Yannis/HMO-5490-2023; Hassandra, Mary/N-3038-2016;
   Hatzigeorgiadis, Antonis/AAN-2725-2020
OI Theodorakis, Yannis/0000-0002-5768-2060; Hassandra,
   Mary/0000-0001-8046-3547; Hatzigeorgiadis, Antonis/0000-0001-7062-479X;
   Tsolaki, Magda/0000-0002-2072-8010; Galanis,
   Evangelos/0000-0001-6525-2012; Petridou, Niki/0000-0001-5993-0024;
   Goudas, Marios/0000-0001-9181-9924; Zikas, Paul/0000-0003-2422-1169
FU European Regional Development Fund of the EU; Greek national funds
   through the Operational Program Competitiveness, Entrepreneurship, and
   Innovation [T1EDK-01448]
FX This research is cofunded by the European Regional Development Fund of
   the EU and Greek national funds through the Operational Program
   Competitiveness, Entrepreneurship, and Innovation, under the call
   RESEARCH-CREATE-INNOVATE (project code: T1EDK-01448). The funding agency
   played no role in the design or execution of the study, analysis or
   interpretation of the data, or decision to submit the results. Data are
   available upon request from YT.
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NR 78
TC 18
Z9 18
U1 14
U2 60
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY E, STE 1102, TORONTO, ON M5A 0P6, CANADA
SN 2291-9279
J9 JMIR SERIOUS GAMES
JI JMIR Serious Games
PD JAN-MAR
PY 2021
VL 9
IS 1
AR E24170
DI 10.2196/24170
PG 21
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Medical Informatics
GA RJ7UP
UT WOS:000637807900004
PM 33759797
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Sung, CM
   Jen, HJ
   Liu, D
   Kustanti, CY
   Chu, H
   Chen, R
   Lin, HC
   Chang, CY
   Chou, KR
AF Sung, Chien-Mei
   Jen, Hsiu-Ju
   Liu, Doresses
   Kustanti, Christina Yeni
   Chu, Hsin
   Chen, Ruey
   Lin, Hui-Chen
   Chang, Ching-Yi
   Chou, Kuei-Ru
TI The effect of cognitive training on domains of attention in older adults
   with mild cognitive impairment and mild dementia: A meta-analysis of
   randomised controlled trials
SO JOURNAL OF GLOBAL HEALTH
LA English
DT Article
ID DOUBLE-BLIND; PEOPLE; MEMORY
AB Background Attention is essential to daily life and cognitive func-tioning, and attention deficits can affect daily functional and social behaviour, such as falls, risky driving, and accidental injuries. How-ever, attention function is important yet easily overlooked in older adults with mild cognitive impairment, and evidence is limited. We aimed to explore the pooled effect of cognitive training on domains of attention in older adults with mild cognitive impairment and mild dementia using a meta-analysis of randomised controlled trials.Methods We searched PubMed, Embase, Scopus, Web of Science, CINAHL, PsycINFO, and Cochrane Library for randomised con-trolled trials (RCTs) up to 3 November 2022. We included partic-ipants aged & GE;50 years diagnosed with cognitive impairment, with various cognitive training interventions as the intervention measures. The primary outcome was overall attention and the secondary out-comes were attention in different domains and global cognitive func-tion. We calculated the Hedges' g and confidence intervals (CIs) us-ing a random-effects model to evaluate the effect size of the outcome measures and evaluated heterogeneity using the & chi;2 test and I2 value.Results We included 17 RCTs and found that cognitive training interventions improve overall attention (Hedges' g = 0.41; 95% CI = 0.13, 0.70), selective attention (Hedges' g = 0.37; 95% CI = 0.19, 0.55), divided attention (Hedges' g = 0.38; 95% CI = 0.03, 0.72), and global cognitive function (Hedges' g = 0.30; 95% CI = 0.02, 0.58) in older adults with mild cognitive impairment, but with relatively low effectiveness.Conclusions Cognitive training intervention can improve some at-tention functions in older adults with mild cognitive impairment. Attention function training should also be incorporated into routine activities and long-term sustainability planning to delay the deteri-oration of attention function in older adults. Besides reducing their risk of abnormal events in daily life (such as falls), it can also improve their quality of life and help reduce the progression of cognitive im-pairment, achieving early detection of secondary prevention.Registration PROSPERO (CRD42022385211).
C1 [Sung, Chien-Mei; Jen, Hsiu-Ju; Liu, Doresses; Kustanti, Christina Yeni; Chen, Ruey; Lin, Hui-Chen; Chang, Ching-Yi; Chou, Kuei-Ru] Taipei Med Univ, Coll Nursing, Sch Nursing, Taipei, Taiwan.
   [Sung, Chien-Mei] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Nursing, New Taipei City, Taiwan.
   [Jen, Hsiu-Ju; Chen, Ruey; Chang, Ching-Yi; Chou, Kuei-Ru] Taipei Med Univ, Shuang Ho Hosp, Dept Nursing, New Taipei City, Taiwan.
   [Liu, Doresses] Taipei Med Univ, Wan Fang Hosp, Dept Nursing, Taipei, Taiwan.
   [Liu, Doresses; Lin, Hui-Chen; Chou, Kuei-Ru] Taipei Med Univ, Res Ctr Nursing Clin Practice, Wan Fang Hosp, Taipei, Taiwan.
   [Kustanti, Christina Yeni] Sekolah Tinggi Ilmu Kesehatan Bethesda Yakkum Yogy, Yogyakarta, Indonesia.
   [Chu, Hsin] Triserv Gen Hosp, Natl Def Med Ctr, Dept Neurol, Taipei, Taiwan.
   [Chu, Hsin] Natl Def Med Ctr, Inst Aerosp & Undersea Med, Sch Med, Taipei, Taiwan.
   [Chen, Ruey] Taipei Med Univ, Coll Nursing, Postbaccalaureate Program Nursing, Taipei, Taiwan.
   [Chou, Kuei-Ru] Taipei Med Univ Hosp, Psychiat Res Ctr, Taipei, Taiwan.
   [Chou, Kuei-Ru] Taipei Med Univ, Neurosci Res Ctr, Taipei, Taiwan.
C3 Taipei Medical University; Fu Jen Catholic University; Fu Jen Catholic
   University Hospital; Taipei Medical University; Taipei Medical
   University; Taipei Municipal WanFang Hospital; Taipei Medical
   University; Taipei Municipal WanFang Hospital; National Defense Medical
   Center; Tri-Service General Hospital; National Defense Medical Center;
   Taipei Medical University; Taipei Medical University; Taipei Medical
   University Hospital; Taipei Medical University
RP Chou, KR (corresponding author), Taipei Med Univ, Coll Nursing, Sch Nursing, Taipei, Taiwan.
EM kueiru@tmu.edu.tw
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NR 37
TC 0
Z9 0
U1 1
U2 1
PU INT SOC GLOBAL HEALTH
PI EDINBURGH
PA CALEDONIAN EXCHANGE, 19A CANNING ST, EDINBURGH, Lothian, ENGLAND
SN 2047-2978
EI 2047-2986
J9 J GLOB HEALTH
JI J. Glob. Health
PY 2023
VL 13
AR 04078
DI 10.7189/jogh.13.04078
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA L6MW2
UT WOS:001024393700001
PM 37387539
OA Green Accepted, gold
DA 2023-08-17
ER

PT J
AU Jean, L
   Bergeron, ME
   Thivierge, S
   Simard, M
AF Jean, Leonie
   Bergeron, Marie-Eve
   Thivierge, Stephanie
   Simard, Martine
TI Cognitive Intervention Programs for Individuals With Mild Cognitive
   Impairment: Systematic Review of the Literature
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE Cognitive intervention; mild cognitive impairment; systematic review
ID REHABILITATION PROGRAM; ALZHEIMER-DISEASE; OLDER-ADULTS; MEMORY
   PERFORMANCE; GENERAL-POPULATION; EVERYDAY FUNCTION; CONVERSION;
   OUTCOMES; BENEFITS; MCI
AB This systematic literature review addressed the efficacy of 15 cognitive intervention programs that have been tested in individuals presenting with mild cognitive impairment of the amnestic type (MCI-A) possibly at risk to progress toward dementia. MEDLINE, PsycINFO, and Current Content databases were searched using the following key terms: cognitive training, cognitive stimulation, cognitive rehabilitation, neuropsychological intervention, memory training, memory stimulation, and Mild Cognitive Impairment. The data showed statistically significant improvements at the end of training on 44% of objective measures of memory, when compared with 12% of objective measures of cognition other than memory. Statistically significant improvements after treatment were obtained on 49% of subjective measures of memory, quality of life, or mood. Samples sizes ranged from 1 to 193 patients with MCI-A but were usually <= 30. Five studies were randomized controlled trials, eight were quasiexperimental designs, and two were single-case investigations. Some programs focused only on memory, whereas other programs used multifaceted approaches targeting two or more cognitive functions. Eight were offered in groups, and seven took place on an individual basis. Recommendations to improve cognitive interventions in MCI-A are proposed, such as using large samples and a robust experimental design, as well as the implementation of a standardized cognitive training manual. Well standardized and validated direct and indirect measures of efficacy and noncognitive outcomes are also a crucial issue. A consensus meeting among all the experts working on cognitive training in this population should occur to provide guidelines to improve this treatment option. (Am J Geriatr Psychiatry 2010; 18:281-296)
C1 [Jean, Leonie] Univ Laval, Ecole Psychol, Sch Psychol, Quebec City, PQ G1V 0A6, Canada.
   Inst Univ Sante Mentale Quebec, Quebec City, PQ, Canada.
C3 Laval University; Laval University
RP Jean, L (corresponding author), Univ Laval, Ecole Psychol, Sch Psychol, 2325 Rue Bibliotheques, Quebec City, PQ G1V 0A6, Canada.
EM leonie.jean.1@ulaval.ca
RI Simard/Q-9675-2019
OI Simard/0000-0003-1257-8275
FU Alzheimer Society of Canada (ASC); Fonds de la Recherche en Santedu
   Quebec (FRSQ); Canadian Institutes of Health Research (CIHR)-Institute
   of Aging (IA); FORMSAV (MEB); FRSQ
FX This work was supported by doctoral training grants awarded by the
   Alzheimer Society of Canada (ASC) co-funded by the Fonds de la Recherche
   en Santedu Quebec (FRSQ) and the Canadian Institutes of Health Research
   (CIHR)-Institute of Aging (IA) (to LJ), by doctoral training grants
   awarded by FORMSAV (MEB) and the ASC cofunded by the FRSQ (to ST), by a
   2005 NARSAD Young Investigator Award and the CIHR-IA (to MS), and by a
   research grant from the ASC (to MS).
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NR 55
TC 207
Z9 217
U1 3
U2 88
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD APR
PY 2010
VL 18
IS 4
BP 281
EP 296
DI 10.1097/JGP.0b013e3181c37ce9
PG 16
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 576RI
UT WOS:000276164700002
PM 20220584
DA 2023-08-17
ER

PT J
AU Mirzal, RA
   Yaqoob, I
AF Mirzal, Raana Ali
   Yaqoob, Irum
TI Effects of Combined Aerobic and Virtual Reality-Based Cognitive Training
   on 76 Years Old Diabetic Male with Mild Cognitive Impairment
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Cognition; Diabetes; Virtual reality
ID METAANALYSIS; ADULTS
AB Aging, along with Type 2 Diabetes Mellitus (T2DM), is a risk factor for the development of mild cognitive impairment (MCI) among older adults. Physical activity is found beneficial for improving the cognitive status among adults with MCI and in even those having dementia. Combined aerobic-cognitive interventions are an engaging substitute or add-on to existing pharmacological management regimens. A 76-year diabetic male having MCI, followed 12 weeks of aerobics-virtual reality (VR)-based cognitive training programme (3days/week). The session comprised of 30 minutes of interactive gaming via xbox-360 Kinect followed by the aerobic phase of 30 minutes using stationary cycle, maintaining the intensity of 40-60% of heart rate reserve (HRR). The cognitive testing included tools for assessing global cognition and executive function. Random plasma glucose level was also noted at baseline, after 6 weeks and 12 weeks post-interventions while vitals including pulse rate, oxygen saturation and blood pressure were documented at baseline and at the end of intervension. Results depict that 12 weeks of aerobic-VR training was effective in improving the cognitive status along with random plasma glucose levels of the patient.
C1 [Mirzal, Raana Ali] Univ Lahore, Dept Rehabil, Islamabad, Pakistan.
   [Yaqoob, Irum] Riphah Int Univ, RCRS, Dept Rehablitat, Islamabad, Pakistan.
RP Yaqoob, I (corresponding author), Riphah Int Univ, RCRS, Dept Rehablitat, Islamabad, Pakistan.
EM irum.memo@gmail.com
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NR 16
TC 6
Z9 8
U1 3
U2 28
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD SEP
PY 2018
VL 28
IS 9
SU 3
SI SI
BP S210
EP S212
DI 10.29271/jcpsp.2018.09.S210
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HT7LY
UT WOS:000464747600022
PM 30173701
DA 2023-08-17
ER

PT J
AU Yu, F
   Lin, FV
   Salisbury, DL
   Shah, KN
   Chow, L
   Vock, D
   Nelson, NW
   Porsteinsson, AP
   Jack, C
AF Yu, Fang
   Lin, Feng Vankee
   Salisbury, Dereck L.
   Shah, Krupa N.
   Chow, Lisa
   Vock, David
   Nelson, Nathaniel W.
   Porsteinsson, Anton P.
   Jack, Clifford, Jr.
TI Efficacy and mechanisms of combined aerobic exercise and cognitive
   training in mild cognitive impairment: study protocol of the ACT trial
SO TRIALS
LA English
DT Article
DE Aerobic exercise; Alzheimer's disease; Cognitive training; Neuroimaging;
   Executive function; Memory; Aerobic fitness
ID ALZHEIMERS ASSOCIATION WORKGROUPS; RANDOMIZED-CONTROLLED-TRIAL;
   OLDER-ADULTS; PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; DIAGNOSTIC
   GUIDELINES; NATIONAL INSTITUTE; PROCESSING SPEED; DISEASE; RISK
AB BackgroundDeveloping non-pharmacological interventions with strong potential to prevent or delay the onset of Alzheimer's disease (AD) in high-risk populations is critical. Aerobic exercise and cognitive training are two promising interventions. Aerobic exercise increases aerobic fitness, which in turn improves brain structure and function, while cognitive training improves selective brain function intensively. Hence, combined aerobic exercise and cognitive training may have a synergistic effect on cognition by complementary strengthening of different neural functions. Few studies have tested the effects of such a combined intervention, and the findings have been discrepant, largely due to varying doses and formats of the interventions.Methods/designThe purpose of this single-blinded, 2x2 factorial phase II randomized controlled trial is to test the efficacy and synergistic effects of a 6-month combined cycling and speed of processing training intervention on cognition and relevant mechanisms (aerobic fitness, cortical thickness, and functional connectivity in the default mode network) in older adults with amnestic mild cognitive impairment. This trial will randomize 128 participants equally to four arms: cycling and speed of processing, cycling only, speed of processing only, or attention control for 6months, and then follow them for another 12months. Cognition and aerobic fitness will be assessed at baseline and at 3, 6, 12, and 18months; cortical thickness and functional connectivity at baseline and at 6, 12, and 18months; Alzheimer's disease (AD) conversion at 6, 12, and 18months. The specific aims are to (1) determine the efficacy and synergistic effects of the combined intervention on cognition over 6months, (2) examine the underlying mechanisms of the combined intervention, and (3) calculate the long-term effect sizes of the combined intervention on cognition and AD conversion. The analysis will use intention-to-treat and linear mixed-effects modeling.DiscussionThis trial will be among the first to test the synergistic effects on cognition and mechanisms (relevant to Alzheimer's-associated neurodegeneration) of a uniquely conceptualized and rigorously designed aerobic exercise and cognitive training intervention in older adults with mild cognitive impairment. It will advance Alzheimer's prevention research by providing precise effect-size estimates of the combined intervention.Trial registrationClinicalTrials.gov, NCT03313895. Registered on 18 October 2017.
C1 [Yu, Fang; Salisbury, Dereck L.] Univ Minnesota, Sch Nursing, 5-160 WDH 1331,308 Harvard St SE, Minneapolis, MN 55455 USA.
   [Lin, Feng Vankee; Shah, Krupa N.; Porsteinsson, Anton P.] Univ Rochester, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA.
   [Chow, Lisa] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA.
   [Vock, David] Univ Minnesota, Div Biostat, Minneapolis, MN USA.
   [Nelson, Nathaniel W.] Univ St Thomas, Minneapolis, MN USA.
   [Jack, Clifford, Jr.] Mayo Clin, Dept Radiol, Rochester, MN USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Rochester; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; University of St Thomas Minnesota; Mayo Clinic
RP Yu, F (corresponding author), Univ Minnesota, Sch Nursing, 5-160 WDH 1331,308 Harvard St SE, Minneapolis, MN 55455 USA.; Lin, FV (corresponding author), Univ Rochester, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM yuxxx244@umn.edu; vankee_lin@urmc.rochester.edu
RI Jack, Clifford R/F-2508-2010; Chow, Lisa/ABD-3140-2020; Chow,
   Lisa/G-8070-2015
OI Jack, Clifford R/0000-0001-7916-622X; Chow, Lisa/0000-0002-6210-2307;
   Chow, Lisa/0000-0002-6210-2307; Vock, David M/0000-0002-5459-9579; Lin,
   Feng Vankee/0000-0003-1945-0362; Porsteinsson,
   Anton/0000-0002-0166-1738; Salisbury, Dereck/0000-0002-0117-2643; Yu,
   Fang/0000-0002-9399-1987
FU National Institute on Aging of the NIH [R01AG055469-01A1]
FX The research study reported in this publication was supported by the
   National Institute on Aging of the NIH, Award Number R01AG055469-01A1.
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NR 67
TC 12
Z9 13
U1 3
U2 32
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD DEC 22
PY 2018
VL 19
AR 700
DI 10.1186/s13063-018-3054-0
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA HF5KF
UT WOS:000454270500005
PM 30577848
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Schmidt, N
   Todt, I
   Berg, D
   Schlenstedt, C
   Folkerts, AK
   Ophey, A
   Dimenshteyn, K
   Elben, S
   Wojtecki, L
   Liepelt-Scarfone, I
   Schulte, C
   Sulzer, P
   Eggers, C
   Kalbe, E
   Witt, K
AF Schmidt, Nele
   Todt, Inken
   Berg, Daniela
   Schlenstedt, Christian
   Folkerts, Ann-Kristin
   Ophey, Anja
   Dimenshteyn, Karina
   Elben, Saskia
   Wojtecki, Lars
   Liepelt-Scarfone, Inga
   Schulte, Claudia
   Sulzer, Patricia
   Eggers, Carsten
   Kalbe, Elke
   Witt, Karsten
TI Memory enhancement by multidomain group cognitive training in patients
   with Parkinson's disease and mild cognitive impairment: long-term
   effects of a multicenter randomized controlled trial
SO JOURNAL OF NEUROLOGY
LA English
DT Article
DE Parkinson&#8217; s disease; Mild cognitive impairment; Cognition;
   Cognitive training; Non-pharmacological intervention; Long-term effects
ID DIAGNOSTIC-CRITERIA; VERBAL MEMORY; OLDER-ADULTS; DEMENTIA; IMPACT;
   EFFICACY; SYSTEM; RECALL
AB Background Meta-analyses indicate positive effects of cognitive training (CT) in patients with Parkinson's disease (PD), however, most previous studies had small sample sizes and did not evaluate long-term follow-up. Therefore, a multicenter randomized controlled, single-blinded trial (Train-ParC study) was conducted to examine CT effects in PD patients with mild cognitive impairment (PD-MCI). Immediately after CT, an enhancement of executive functions was demonstrated. Here, we present the long-term results 6 and 12 months after CT. Methods At baseline, 64 PD-MCI patients were randomized to a multidomain CT group (n = 33) or to a low-intensity physical activity training control group (PT) (n = 31). Both interventions included 90 min training sessions twice a week for 6 weeks. 54 patients completed the 6 months (CT: n = 28, PT: n = 26) and 49 patients the 12 months follow-up assessment (CT: n = 25, PT: n = 24). Primary study outcomes were memory and executive functioning composite scores. Mixed repeated measures ANOVAs, post-hoc t tests and multiple regression analyses were conducted. Results We found a significant time x group interaction effect for the memory composite score (p = 0.006, eta(2) = 0.214), but not for the executive composite score (p = 0.967, eta(2) = 0.002). Post-hoc t tests revealed significant verbal and nonverbal memory improvements from pre-intervention to 6 months, but not to 12 months follow-up assessment in the CT group. No significant predictors were found for predicting memory improvement after CT. Conclusions This study provides Class 1 evidence that multidomain CT enhances memory functioning in PD-MCI after 6 months but not after 12 months, whereas executive functioning did not change in the long-term.
C1 [Schmidt, Nele; Witt, Karsten] Carl von Ossietzky Univ Oldenburg, Dept Neurol, Steinweg 13-17, D-26122 Oldenburg, Germany.
   [Schmidt, Nele; Todt, Inken; Berg, Daniela; Schlenstedt, Christian] Univ Kiel, Univ Hosp Schleswig Holstein, Dept Neurol, Kiel, Germany.
   [Folkerts, Ann-Kristin; Ophey, Anja; Kalbe, Elke] Univ Cologne, Fac Med, Ctr Neuropsychol Diagnost & Intervent CeNDI, Med Psychol Neuropsychol & Gender Studies, Cologne, Germany.
   [Folkerts, Ann-Kristin; Ophey, Anja; Eggers, Carsten; Kalbe, Elke] Univ Cologne, Univ Hosp Cologne, Cologne, Germany.
   [Dimenshteyn, Karina; Elben, Saskia; Wojtecki, Lars] Heinrich Heine Univ Duesseldorf, Ctr Movement Disorders & Neuromodulat, Dept Neurol, Dusseldorf, Germany.
   [Dimenshteyn, Karina; Elben, Saskia; Wojtecki, Lars] Heinrich Heine Univ Duesseldorf, Med Fac, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany.
   [Liepelt-Scarfone, Inga; Schulte, Claudia; Sulzer, Patricia] Univ Tubingen, German Ctr Neurodegenerat Dis DZNE, Dept Neurodegenerat Dis, Tubingen, Germany.
   [Liepelt-Scarfone, Inga; Schulte, Claudia; Sulzer, Patricia] Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany.
   [Liepelt-Scarfone, Inga] IB Hsch Gesundheit & Sozi, Stuttgart, Germany.
   [Eggers, Carsten] Univ Marburg, Univ Hosp Marburg, Ctr Mind Brain & Behav CMBB, Dept Neurol, Marburg, Germany.
   [Eggers, Carsten] Univ Giessen, Marburg, Germany.
   [Eggers, Carsten] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany.
   [Witt, Karsten] Carl Von Ossietzky Univ Oldenburg, Res Ctr Neurosensory Sci, Oldenburg, Germany.
C3 Carl von Ossietzky Universitat Oldenburg; University of Kiel; Schleswig
   Holstein University Hospital; University of Cologne; University of
   Cologne; Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE); Eberhard Karls University of
   Tubingen; Eberhard Karls University Hospital; Philipps University
   Marburg; University Hospital of Giessen & Marburg; Justus Liebig
   University Giessen; University of Cologne; Carl von Ossietzky
   Universitat Oldenburg
RP Witt, K (corresponding author), Carl von Ossietzky Univ Oldenburg, Dept Neurol, Steinweg 13-17, D-26122 Oldenburg, Germany.; Witt, K (corresponding author), Carl Von Ossietzky Univ Oldenburg, Res Ctr Neurosensory Sci, Oldenburg, Germany.
EM karsten.witt@uni-oldenburg.de
RI Wojtecki, Lars/AAT-6604-2021; Ophey, Anja/ABE-2010-2021; Ophey,
   Anja/HTQ-7893-2023; Berg, Daniela/A-8728-2019
OI Wojtecki, Lars/0000-0002-6205-4405; Ophey, Anja/0000-0001-5858-7762;
   Berg, Daniela/0000-0001-5796-5442; Schlenstedt,
   Christian/0000-0002-3838-6848
FU Parkinson-Fonds Germany; German Centre for Neurodegenerative diseases
   (DZNE) e.V.; Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. This study
   was partly supported by a grant from the Parkinson-Fonds Germany. Design
   of the database was supported by the German Centre for Neurodegenerative
   diseases (DZNE) e.V.
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NR 60
TC 5
Z9 6
U1 1
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5354
EI 1432-1459
J9 J NEUROL
JI J. Neurol.
PD DEC
PY 2021
VL 268
IS 12
BP 4655
EP 4666
DI 10.1007/s00415-021-10568-9
EA APR 2021
PG 12
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA WQ8VN
UT WOS:000644754900001
PM 33904966
OA hybrid, Green Published
DA 2023-08-17
ER

PT J
AU Chan, JYC
   Chan, TK
   Kwok, TCY
   Wong, SYS
   Lee, ATC
   Tsoi, KKF
AF Chan, Joyce Y. C.
   Chan, Tak Kit
   Kwok, Timothy C. Y.
   Wong, Samuel Y. S.
   Lee, Allen T. C.
   Tsoi, Kelvin K. F.
TI Cognitive training interventions and depression in mild cognitive
   impairment and dementia: a systematic review and meta-analysis of
   randomized controlled trials
SO AGE AND AGEING
LA English
DT Review
DE cognitive training interventions; depression; mild cognitive impairment
   (MCI); dementia; older people
ID ALZHEIMERS-DISEASE; SOCIAL SUPPORT; SYMPTOMS; THERAPY; PEOPLE;
   PERSONALITY; ANXIETY; DECLINE
AB Background: Depression is common in people with cognitive impairment but the effect of cognitive training in the reduction of depression is still uncertain.
   Aims: The purpose of this paper is to evaluate the effect of cognitive training interventions in the reduction of depression rating scale score in people with cognitive impairment.
   Methods: Literature searches were conducted via OVID databases. Randomized controlled trials (RCTs) evaluated the effect of cognitive training interventions for the reduction of depression rating scale score in people with mild cognitive impairment (MCI) or dementia were included. Mean difference (MD) with 95% confidence interval (CI) was used to combine the results of Geriatric Depression Scale (GDS). Standardized mean difference (SMD) was used to combine the results of different depression rating scales. Subgroup analyses were conducted according to the types of cognitive training and severity of cognitive impairment, i.e. MCI and dementia.
   Results: A total of 2551 people with MCI or dementia were extracted from 36 RCTs. The baseline mean score of GDS-15 was 4.83. Participants received cognitive training interventions had a significant decrease in depression rating scale score than the control group (MD of GDS-15=-1.30, 95% CI=-2.14--0.47; and SMD of eight depression scales was -0.54 (95% CI=-0.77--0.31). In subgroup analyses, the effect size of computerized cognitive training and cognitive stimulation therapy were medium-to-large and statistically significant in the reduction of depression rating scale score.
   Conclusions: Cognitive training interventions show to be a potential treatment to ameliorate depression in people with cognitive impairment.
C1 [Chan, Joyce Y. C.; Kwok, Timothy C. Y.] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.
   [Chan, Tak Kit; Wong, Samuel Y. S.; Tsoi, Kelvin K. F.] Prince Wales Hosp, Jockey Club Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China.
   [Lee, Allen T. C.] Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China.
   [Tsoi, Kelvin K. F.] Chinese Univ Hong Kong, Stanley Ho Big Data Decis Analyt Res Ctr, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong; Prince
   of Wales Hospital; Chinese University of Hong Kong; Chinese University
   of Hong Kong
RP Tsoi, KKF (corresponding author), Prince Wales Hosp, Jockey Club Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China.; Tsoi, KKF (corresponding author), Chinese Univ Hong Kong, Stanley Ho Big Data Decis Analyt Res Ctr, Hong Kong, Peoples R China.
EM kelvintsoi@cuhk.edu.hk
RI Lee, Allen/AEP-1064-2022; Kwok, Timothy/C-3725-2008
OI Kwok, Timothy/0000-0001-9253-3549; Chan, Joyce YC/0000-0001-6329-7727;
   Lee, Allen/0000-0003-4196-5442
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NR 29
TC 14
Z9 19
U1 8
U2 38
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-0729
EI 1468-2834
J9 AGE AGEING
JI Age Ageing
PD SEP
PY 2020
VL 49
IS 5
BP 738
EP 747
DI 10.1093/ageing/afaa063
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA OF1IX
UT WOS:000580971800014
PM 32378715
OA Bronze
DA 2023-08-17
ER

PT J
AU Book, S
   Jank, M
   Pendergrass, A
   Graessel, E
AF Book, Stephanie
   Jank, Michael
   Pendergrass, Anna
   Graessel, Elmar
TI Individualised computerised cognitive training for community-dwelling
   people with mild cognitive impairment: study protocol of a completely
   virtual, randomised, controlled trial
SO TRIALS
LA English
DT Article
DE Community-dwelling; Computerised cognitive training; Mild cognitive
   impairment; Nonpharmacological intervention; Randomised controlled trial
ID MINI-MENTAL-STATE; DEMENTIA; INTERVENTIONS; DEPRESSION; VALIDITY;
   THERAPY; PHQ-9; RISK; MOCA; TOOL
AB Background: People with mild cognitive impairment (MCI) are at increased risk of converting to dementia. Cognitive training can improve the cognitive abilities of people with MCI. Computerised cognitive training (CCT) offers several advantages over traditional paper-and-pencil cognitive training and has the potential to be more individualised by matching task difficulty with individual performance. Recent systematic reviews have reported promising effects of CCT on improving the cognitive capacities of people with MCI. However, the quality of existing studies has been limited, and it is still unclear whether CCT can influence the progression to dementia. We developed an 'individualised' CCT (MAKSCog) specialised for people with MCI that automatically matches task difficulty with individual performance and an active control training ('basic' CCT). The aims of the present study are (a) to evaluate MAKSCog and (b) to investigate whether it can be applied to maintain the cognitive abilities of people with MCI.
   Methods: The present study investigates the effects of CCT on cognition in a randomised controlled intervention study in Germany. Participants are community-dwelling people with a psychometric diagnosis of MCI based on the Montreal Cognitive Assessment (MoCA) and Mini-Mental Status Test (MMSE). Screening and baseline testing are conducted via a videoconferencing assessment and telephone. Participants are randomly allocated. The treatment phase is 6 months with an open phase in which participants can freely decide to continue to use the CCTs. Additionally, both CCTs contain a monthly computerised cognitive assessment that measures different cognitive abilities: information processing speed, memory span, short term memory, and logical reasoning.
   Discussion: This is the first study to investigate the effect of MAKSCog, an individualised CCT, specifically developed for people with different subtypes of MCI. A methodological strength is the double-blind, randomised, controlled design and the use of basic co - as an active control group. The study is conducted entirely virtually with valid telehealth assessments for cognitive function. Methodological limitations might include a restriction to participants who feel comfortable with the use of technology and who own a computer, laptop, or tablet.
C1 [Book, Stephanie; Jank, Michael; Pendergrass, Anna; Graessel, Elmar] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Ctr Hlth Serv Res Med, Dept Psychiat & Psychotherapy, Schwabachanlage 6, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Book, S (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Ctr Hlth Serv Res Med, Dept Psychiat & Psychotherapy, Schwabachanlage 6, D-91054 Erlangen, Germany.
EM stephanie.book@uk-erlangem.de
FU Reinhard Frank-Stiftung (Hamburg, Germany)
FX This work was supported by the Reinhard Frank-Stiftung (Monckebergerstr.
   11 20095 Hamburg, Germany). The funding body has no role in the study
   design, the collection, analysis, or interpretation of the data, or in
   writing the manuscript.
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NR 51
TC 0
Z9 0
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD MAY 5
PY 2022
VL 23
IS 1
AR 371
DI 10.1186/s13063-022-06152-9
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 0Z7VP
UT WOS:000791281600001
PM 35513855
DA 2023-08-17
ER

PT J
AU Singh, MAF
   Gates, N
   Saigal, N
   Wilson, GC
   Meiklejohn, J
   Brodaty, H
   Wen, W
   Singh, N
   Baune, BT
   Suo, C
   Baker, MK
   Foroughi, N
   Wang, Y
   Sachdev, PS
   Valenzuela, M
AF Singh, Maria A. Fiatarone
   Gates, Nicola
   Saigal, Nidhi
   Wilson, Guy C.
   Meiklejohn, Jacinda
   Brodaty, Henry
   Wen, Wei
   Singh, Nalin
   Baune, Bernhard T.
   Suo, Chao
   Baker, Michael K.
   Foroughi, Nasim
   Wang, Yi
   Sachdev, Perminder S.
   Valenzuela, Michael
TI The Study of Mental and Resistance Training (SMART) Study-Resistance
   Training and/or Cognitive Training in Mild Cognitive Impairment: A
   Randomized, Double-Blind, Double-Sham Controlled Trial
SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
LA English
DT Article
DE Mild cognitive impairment; resistance training; cognitive training
ID OLDER-ADULTS; PHYSICAL-ACTIVITY; ALZHEIMERS-DISEASE; AEROBIC EXERCISE;
   BRAIN RESERVE; RISK; METAANALYSIS; DEMENTIA; STRENGTH; HEALTH
AB Background: Mild cognitive impairment (MCI) increases dementia risk with no pharmacologic treatment available.
   Methods: The Study of Mental and Resistance Training was a randomized, double-blind, double-sham controlled trial of adults with MCI. Participants were randomized to 2 supervised interventions: active or sham physical training (high intensity progressive resistance training vs seated calisthenics) plus active or sham cognitive training (computerized, multidomain cognitive training vs watching videos/quizzes), 2-3 days/week for 6 months with 18-month follow-up. Primary outcomes were global cognitive function (Alzheimer's Disease Assessment Scale-cognitive subscale; ADAS-Cog) and functional independence (Bayer Activities of Daily Living). Secondary outcomes included executive function, memory, and speed/attention tests, and cognitive domain scores.
   Results: One hundred adults with MCI [70.1 (6.7) years; 68% women] were enrolled and analyzed. Resistance training significantly improved the primary outcome ADAS-Cog; [relative effect size (95% confidence interval) -0.33 (-0.73, 0.06); P <.05] at 6 months and executive function (Wechsler Adult Intelligence Scale Matrices; P = .016) across 18 months. Normal ADAS-Cog scores occurred in 48% (24/ 49) after resistance training vs 27% (14/ 51) without resistance training [P <.03; odds ratio (95% confidence interval) 3.50 (1.18, 10.48)].
   Cognitive training only attenuated decline in Memory Domain at 6 months (P < . 02). Resistance training 18-month benefit was 74% higher (P = .02) for Executive Domain compared with combined training [z-score change -0.42 (0.22, 0.63) resistance training vs 0.11 (-0.60, 0.28) combined] and 48% higher (P <.04) for Global Domain [z-score change -.0.45 (0.29, 0.61) resistance training vs 0.23 (0.10, 0.36) combined]. Conclusions: Resistance training significantly improved global cognitive function, with maintenance of executive and global benefits over 18 months. (C) 2014 AMDA e The Society for Post-Acute and Long-Term Care Medicine.
C1 [Singh, Maria A. Fiatarone] Univ Sydney, Fac Hlth Sci, Hlth & Performance Fac Res Grp, Sydney Med Sch, Lidcombe, NSW 2141, Australia.
   [Singh, Maria A. Fiatarone] Hebrew SeniorLife, Boston, MA USA.
   [Singh, Maria A. Fiatarone] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Gates, Nicola] Private Neuropsychol Practice, Mosman, NSW, Australia.
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C3 University of Sydney; Harvard University; Hebrew SeniorLife; Tufts
   University; United States Department of Agriculture (USDA); University
   of Sydney; University of New South Wales Sydney; University of Sydney;
   University of Adelaide; Monash University; Australian Catholic
   University; University of Sydney; University of California System;
   University of California San Francisco; University of Sydney
RP Singh, MAF (corresponding author), Univ Sydney, Fac Hlth Sci, Hlth & Rehabil Fac Res Grp, 75 East St, Lidcombe, NSW 2141, Australia.
EM maria.fiataronesingh@sydney.edu.au
RI Brodaty, Henry/E-2753-2010; Baker, Michael K/E-9514-2010; Wilson, Guy
   Charles/AAE-8365-2022; Sachdev, Perminder/ABC-1137-2020; Wen,
   Wei/J-7837-2015
OI Brodaty, Henry/0000-0001-9487-6617; Wilson, Guy
   Charles/0000-0001-5730-162X; Sachdev, Perminder/0000-0002-9595-3220;
   Wen, Wei/0000-0003-4720-3027; Baker, Michael/0000-0002-0551-4209; Wang,
   Yi/0000-0002-6074-0532; Valenzuela, Michael/0000-0001-7162-6607; Wen,
   Wei/0000-0003-2753-3870
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NR 40
TC 163
Z9 169
U1 3
U2 99
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1525-8610
EI 1538-9375
J9 J AM MED DIR ASSOC
JI J. Am. Med. Dir. Assoc.
PD DEC
PY 2014
VL 15
IS 12
BP 873
EP 880
DI 10.1016/j.jamda.2014.09.010
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AU3GD
UT WOS:000345499500005
PM 25444575
DA 2023-08-17
ER

PT J
AU Unverzagt, FW
   Smith, DM
   Rebok, GW
   Marsiske, M
   Morris, JN
   Jones, R
   Willis, SL
   Ball, K
   King, JW
   Koepke, KM
   Stoddard, A
   Tennstedt, SL
AF Unverzagt, Frederick W.
   Smith, David M.
   Rebok, George W.
   Marsiske, Michael
   Morris, John N.
   Jones, Richard
   Willis, Sherry L.
   Ball, Karlene
   King, Jonathan W.
   Koepke, Kathy Mann
   Stoddard, Anne
   Tennstedt, Sharon L.
TI The Indiana Alzheimer Disease Center's Symposium on Mild Cognitive
   Impairment. Cognitive Training in Older Adults: Lessons from the ACTIVE
   Study
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Article
ID TRIAL; PERFORMANCE; TASKS
AB This paper is based on a presentation made during the Indiana Alzheimer Disease Center's Symposium on Mild Cognitive Impairment on April 19, 2008. The results of the ACTIVE study (Advanced Cognitive Training for Independent and Vital Elderly) were presented at the symposium including review of previously published study findings. The ACTIVE study is a multicenter, randomized, controlled clinical trial that has been examining the long-term effectiveness of cognitive training on enhancing mental abilities (memory, reasoning, and attention) and preserving activities of daily living (managing finances, taking medication, using the telephone, and driving) in older adults. Six centers across the eastern United States enrolled nearly 3000 people initially. Participants underwent detailed assessments of mental and functional ability on multiple occasions over several years of follow-up. ACTIVE has shown positive effects of cognitive training at 5 years post-intervention for basic mental abilities, health-related quality of life, and improved ability to perform instrumental activities of daily living (IADL). A subgroup analysis through 2 years of follow-up suggested that subjects with mild cognitive impairment (MCI) did not benefit from memory training; however, they did benefit, to the same degree as cognitively normal participants, from training in reasoning and speed of processing. This finding suggests that MCI may interfere with a person's ability to benefit from some forms of cognitive enhancement. Limitations of ACTIVE and directions for future research are reviewed.
C1 [Unverzagt, Frederick W.] Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
   [Smith, David M.] Indiana Univ, Sch Med, Dept Med, Bloomington, IN 47405 USA.
   [Rebok, George W.] Johns Hopkins Univ, Dept Mental Hlth, Baltimore, MD 21218 USA.
   [Marsiske, Michael] Univ Florida, Inst Aging, Gainesville, FL 32611 USA.
   [Marsiske, Michael] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32611 USA.
   [Willis, Sherry L.] Penn State Univ, Dept Human Dev & Family Studies, University Pk, PA 16802 USA.
   [Ball, Karlene] Univ Alabama, Dept Psychol, Birmingham, AL USA.
   [King, Jonathan W.] NIA, Bethesda, MD 20892 USA.
   [Koepke, Kathy Mann] NINR, Bethesda, MD USA.
C3 Indiana University System; Indiana University-Purdue University
   Indianapolis; Indiana University System; Indiana University Bloomington;
   Johns Hopkins University; State University System of Florida; University
   of Florida; State University System of Florida; University of Florida;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; University of Alabama System; University of Alabama
   Birmingham; National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH
   National Institute of Nursing Research (NINR)
RP Unverzagt, FW (corresponding author), Indiana Univ, Sch Med, Dept Psychiat, 1111 W 10th St,Suite PB 218A, Indianapolis, IN 46202 USA.
EM funverza@iupui.edu
RI Jones, Richard Norman/J-3488-2013; Abellan Vidal, Maria
   Teresa/HLX-5905-2023
OI Jones, Richard Norman/0000-0002-1049-218X; Ball,
   Karlene/0000-0003-1811-9870; Marsiske, Michael/0000-0001-5973-2116
FU National Institutes of Health [R01 NR04508, R01 AG026096, P30 AG10133];
   Hebrew Senior Life, Boston [R01 NR04507]; Johns Hopkins University [R01
   AG14260]; New England Research Institutes [R01 AG14282]; Pennsylvania
   State University [R01 AG14263]; University of Alabama at Birmingham [R01
   AG14289]; University of Florida [R01 AG014276]; Posit Science
FX Supported by grants from the National Institutes of Health to six field
   sites and the coordinating center, including: Indiana University School
   of Medicine (R01 NR04508; R01 AG026096; and P30 AG10133), Hebrew Senior
   Life, Boston (R01 NR04507), Johns Hopkins University (R01 AG14260), New
   England Research Institutes (R01 AG14282), Pennsylvania State University
   (R01 AG14263), University of Alabama at Birmingham (R01 AG14289), and
   University of Florida (R01 AG014276). Dr. Rebok is an investigator with
   Compact Disc Incorporated for the development of an electronic version
   of the ACTIVE memory intervention. Dr. Marsiske has received support
   from Posit Science in the form of site licenses for the Insight program
   for a different research project. Karlene Ball owns stock in the Visual
   Awareness Research Group (formerly Visual Awareness, Inc.), and Posit
   Science, Inc., the companies that market the Useful Field of View Test
   and speed of processing training software (now called Insight). Posit
   Science acquired Visual Awareness, and Dr. Ball continues to collaborate
   on the design and testing of these assessment and training programs as a
   member of the Posit Science Scientific Advisory Board.
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NR 23
TC 21
Z9 23
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PD AUG
PY 2009
VL 6
IS 4
BP 375
EP 383
DI 10.2174/156720509788929345
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 513SS
UT WOS:000271344300010
PM 19689237
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Baquero, AAD
   Bartolome, MVP
   Toribio-Guzman, JM
   Martinez-Abad, F
   Vidales, EP
   Aguado, YB
   van der Roest, HG
   Franco-Martin, MA
AF Diaz Baquero, Angie A.
   Perea Bartolome, Maria, V
   Miguel Toribio-Guzman, Jose
   Martinez-Abad, Fernando
   Parra Vidales, Esther
   Bueno Aguado, Yolanda
   van der Roest, Henriette G.
   Franco-Martin, Manuel A.
TI Determinants of Adherence to a "GRADIOR" Computer-Based Cognitive
   Training Program in People with Mild Cognitive Impairment (MCI) and Mild
   Dementia
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE dementia; rehabilitation; software; computer-based; cognition;
   psychology
ID EXECUTIVE FUNCTION DEFICITS; MINI-MENTAL STATE; OLDER-ADULTS;
   ALZHEIMERS-DISEASE; PATIENT ADHERENCE; MEMORY; REHABILITATION;
   INTERVENTION; PERSISTENCE; PREDICTORS
AB Background: Computer-based programs have been implemented from a psychosocial approach for the care of people with dementia (PwD). However, several factors may determine adherence of older PwD to this type of treatment. The aim of this paper was to identify the sociodemographic, cognitive, psychological, and physical-health determinants that helped predict adherence or not to a "GRADIOR" computerized cognitive training (CCT) program in people with mild cognitive impairment (MCI) and mild dementia. Method: This study was part of a randomized clinical trial (RCT) (ISRCTN: 15742788). However, this study will only focus on the experimental group (n = 43) included in the RCT. This group was divided into adherent people (compliance: >= 60% of the sessions and persistence in treatment up to 4 months) and non-adherent. The participants were 60-90 age and diagnosed with MCI and mild dementia. We selected from the evaluation protocol for the RCT, tests that evaluated cognitive aspects (memory and executive functioning), psychological and physical health. The CCT with GRADIOR consisted of attending 2-3 weekly sessions for 4 months with a duration of 30 min Data analysis: Phi and Biserial-point correlations, a multiple logical regression analysis was obtained to find the adherence model and U Mann-Whitney was used. Results: The adherence model was made up of the Digit Symbol and Arithmetic of Wechsler Adult Intelligence Scale (WAIS-III) and Lexical Verbal Fluency (LVF) -R tests. This model had 90% sensitivity, 50% specificity and 75% precision. The goodness-of-fit p-value of the model was 0.02. Conclusions: good executive functioning in attention, working memory (WM), phonological verbal fluency and cognitive flexibility predicted a greater probability that a person would be adherent.
C1 [Diaz Baquero, Angie A.; Franco-Martin, Manuel A.] Univ Salamanca, Inst Biomed Res Salamanca, Salamanca 37001, Spain.
   [Diaz Baquero, Angie A.; Miguel Toribio-Guzman, Jose] INTRAS Fdn, Dept Res & Dev, Zamora 49001, Spain.
   [Perea Bartolome, Maria, V] Salamanca Univ, Basic Psychol Psychobiol & Methodol Dept, Salamanca 37001, Spain.
   [Martinez-Abad, Fernando] Univ Salamanca, Univ Inst Educ Sci, Salamanca 37008, Spain.
   [Parra Vidales, Esther] INTRAS Fdn, IBIP Ctr Clin Care Mental Hlth & Aging, Zamora 49024, Spain.
   [Bueno Aguado, Yolanda] INTRAS Fdn, Gradior Dept, Valladolid 47016, Spain.
   [Bueno Aguado, Yolanda] INTRAS Fdn, Cognit Res, Valladolid 47016, Spain.
   [van der Roest, Henriette G.] Netherlands Inst Mental Hlth & Addict, Dept Aging, TrimbosI Inst, NL-1013 GM Utrecht, Netherlands.
   [Franco-Martin, Manuel A.] Rio Hortega Univ Hosp, Psychiat Dept, Valladolid 47012, Spain.
   [Franco-Martin, Manuel A.] Zamora Healthcare Complex, Psychiat Dept, Zamora 49071, Spain.
C3 University of Salamanca; University of Salamanca; Trimbos Institute;
   Hospital del Rio Hortega
RP Baquero, AAD (corresponding author), Univ Salamanca, Inst Biomed Res Salamanca, Salamanca 37001, Spain.; Baquero, AAD (corresponding author), INTRAS Fdn, Dept Res & Dev, Zamora 49001, Spain.
EM alejadiaz93@usal.es; vperea@usal.es; jmtg@intras.es; fma@usal.es;
   epv@intras.es; yba@intras.es; hroest@trimbos.nl; mfm@intras.es
RI Toribio-Guzmán, José Miguel/HMP-7789-2023; Franco-Martin,
   Manuel/D-1752-2011; Martinez-Abad, Fernando/H-3129-2015
OI Franco-Martin, Manuel/0000-0002-3639-2523; DIAZ BAQUERO, ANGIE
   ALEJANDRA/0000-0002-0815-4480; van der Roest,
   Henriette/0000-0001-9898-923X; Toribio-Guzman, Jose
   Miguel/0000-0002-5678-3150; PARRA VIDALES, ESTHER/0000-0001-7061-5148;
   Martinez-Abad, Fernando/0000-0002-1783-8198
FU Marie Curie Initial Training Network (ITN) action, H2020-MSCA-ITN-2015
   [676265]; INDUCT: Interdisciplinary Network for Dementia Using Current
   Technology; H2020 Marie Sklodowska Curie Actions-Innovative Training
   Networks, 2015
FX The research presented in this paper was carried out as part of the
   Marie Curie Initial Training Network (ITN) action, H2020-MSCA-ITN-2015,
   under grant agreement number 676265. INDUCT: Interdisciplinary Network
   for Dementia Using Current Technology. H2020 Marie Sklodowska Curie
   Actions-Innovative Training Networks, 2015.
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NR 74
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2022
VL 11
IS 6
AR 1714
DI 10.3390/jcm11061714
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 0C2SI
UT WOS:000775169000001
PM 35330040
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Tang, Y
   Xing, Y
   Zhu, ZD
   He, Y
   Li, F
   Yang, JW
   Liu, Q
   Li, FY
   Teipel, SJ
   Zhao, GG
   Jia, JP
AF Tang, Yi
   Xing, Yi
   Zhu, Zude
   He, Yong
   Li, Fang
   Yang, Jianwei
   Liu, Qing
   Li, Fangyu
   Teipel, Stefan J.
   Zhao, Guoguang
   Jia, Jianping
TI The effects of 7-week cognitive training in patients with vascular
   cognitive impairment, no dementia (the Cog-VACCINE study): A randomized
   controlled trial
SO ALZHEIMERS & DEMENTIA
LA English
DT Article
DE Vascular cognitive impairment no dementia; Computerized cognitive
   training; Randomized controlled trial; Brain plasticity
ID FUNCTIONAL CONNECTIVITY; ALZHEIMERS-DISEASE; BRAIN; PLASTICITY;
   PREVALENCE; OUTCOMES; MRI
AB Introduction: Evidence for the efficacy of cognitive training in patients with subcortical vascular cognitive impairment no dementia is still lacking.
   Methods: A randomized, active controlled design using multidomain, adaptive, computerized cognitive training for 30 minutes, 5 days/week for 7 weeks. Assessments included global cognitive function and executive function (primary outcomes) and brain functional connectivity and structural changes (secondary outcomes).
   Results: Sixty patients were randomized across three medical centers in Beijing. At the end of the intervention, the cognitive training group showed significant improvement in Montreal Cognitive Assessment relative to the active control group (P = .013) and significantly increased functional connectivity between the left dorsolateral prefrontal cortex and medial prefrontal cortex, which was significantly correlated with Montreal Cognitive Assessment change (P = .017).
   Discussion: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
C1 [Tang, Yi; Xing, Yi; Yang, Jianwei; Liu, Qing; Li, Fangyu; Jia, Jianping] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China.
   [Tang, Yi; Xing, Yi; Yang, Jianwei; Liu, Qing; Li, Fangyu; Jia, Jianping] Capital Med Univ, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Beijing, Peoples R China.
   [Tang, Yi; Xing, Yi; Yang, Jianwei; Li, Fangyu; Jia, Jianping] Minist Educ Peoples Republ China, Key Lab Neurodegenerat Dis, Beijing, Peoples R China.
   [Zhu, Zude] Jiangsu Normal Univ, Collaborat Innovat Ctr Language Abil, Xuzhou, Jiangsu, Peoples R China.
   [He, Yong] State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China.
   [He, Yong] Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China.
   [He, Yong] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China.
   [Li, Fang] Capital Med Univ, Fu Xing Hosp, Dept Geriatr, Beijing, Peoples R China.
   [Teipel, Stefan J.] Univ Med Rostock, Dept Psychosomat Med, Rostock, Germany.
   [Teipel, Stefan J.] German Ctr Neurodegenerat Dis, DZNE, Rostock, Germany.
   [Zhao, Guoguang] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China.
   [Jia, Jianping] Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China.
   [Jia, Jianping] Beijing Key Lab Geriatr Cognit Disorders, Beijing, Peoples R China.
   [Jia, Jianping] Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China.
   [Jia, Jianping] Capital Med Univ, Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Jiangsu Normal
   University; Beijing Normal University; Capital Medical University;
   University of Rostock; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE); Capital Medical University; Capital
   Medical University
RP Tang, Y; Jia, JP (corresponding author), Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China.; Tang, Y; Jia, JP (corresponding author), Capital Med Univ, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Beijing, Peoples R China.; Tang, Y; Jia, JP (corresponding author), Minist Educ Peoples Republ China, Key Lab Neurodegenerat Dis, Beijing, Peoples R China.; Zhao, GG (corresponding author), Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China.; Jia, JP (corresponding author), Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China.; Jia, JP (corresponding author), Beijing Key Lab Geriatr Cognit Disorders, Beijing, Peoples R China.; Jia, JP (corresponding author), Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China.; Jia, JP (corresponding author), Capital Med Univ, Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China.
EM tangyi@xwhosp.org; ggzhao@vip.sina.com; jiajp@vip.126.com
RI He, Yong/Q-5756-2018
OI Jia, Jianping/0000-0003-4624-0336; He, Yong/0000-0002-7039-2850
FU National Key R&D Program of China [2017YFC1310102]; National Natural
   Science Foundation of China [81671040, 31571156, 31871133, 81701044];
   Beijing Municipal Administration of Hospital's Youth Program
   [QML20170801]; Beijing Municipal Science & Technology Commission
   [Z151100004015078]
FX This study was funded by the National Key R&D Program of China
   (2017YFC1310102), National Natural Science Foundation of China
   (81671040, 31571156, 31871133, and 81701044), Beijing Municipal
   Administration of Hospital's Youth Program (QML20170801), and Beijing
   Municipal Science & Technology Commission (Z151100004015078).
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NR 32
TC 29
Z9 39
U1 3
U2 68
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1552-5260
EI 1552-5279
J9 ALZHEIMERS DEMENT
JI Alzheimers. Dement.
PD MAY
PY 2019
VL 15
IS 5
BP 605
EP 614
DI 10.1016/j.jalz.2019.01.009
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA HX2KN
UT WOS:000467220800001
PM 30894299
DA 2023-08-17
ER

PT J
AU Amoyal, N
   Fallon, E
AF Amoyal, Nicole
   Fallon, Elizabeth
TI Physical Exercise and Cognitive Training Clinical Interventions Used in
   Slowing Degeneration Associated With Mild Cognitive Impairment A Review
   of the Recent Literature
SO TOPICS IN GERIATRIC REHABILITATION
LA English
DT Review
DE Alzheimer disease; cognitive training; mild cognitive impairment;
   nonpharmacologic interventions; physical exercise; plasticity
ID PLASMINOGEN-ACTIVATOR; AEROBIC EXERCISE; PLASTICITY; DEMENTIA;
   EXCITABILITY; PREVALENCE
AB Recent literature provides empirical evidence for nonpharmacologic interventions' potential to slow degeneration associated with mild cognitive impairment. Physical exercise and cognitive training interventions have showed trending toward slowing degenerative processes associated with dementia, specifically related to plasticity. A review of 6 clinical trials (2 physical exercise and 4 cognitive training) showing trending toward slowing degenerative processes in mild cognitive impairment is provided. Brain and metabolic changes associated with plasticity were associated with neuropsychological test performance. Several strengths, limitations, and suggestions for future empirical research were offered. Nonpharmacologic interventions should continue to be developed and tested via clinical trials with mild cognitive impairment patients.
C1 [Amoyal, Nicole; Fallon, Elizabeth] Univ Rhode Isl, Canc Prevent Res Ctr, Kingston, RI 02881 USA.
C3 University of Rhode Island
RP Amoyal, N (corresponding author), Univ Rhode Isl, Canc Prevent Res Ctr, 2 Chafee Rd, Kingston, RI 02881 USA.
EM nnamoyal@gmail.com
RI Fallon, Elizabeth/D-9126-2016
OI Fallon, Elizabeth/0000-0002-9083-6682
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NR 37
TC 10
Z9 10
U1 3
U2 35
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0882-7524
EI 1550-2414
J9 TOP GERIATR REHABIL
JI Top. Geriatr. Rehabil.
PD JUL-SEP
PY 2012
VL 28
IS 3
BP 208
EP 216
DI 10.1097/TGR.0b013e31825fc8d3
PG 9
WC Gerontology; Rehabilitation
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Rehabilitation
GA 979WK
UT WOS:000306853200011
DA 2023-08-17
ER

PT J
AU Han, E
   Park, J
   Kim, H
   Jo, G
   Do, HK
   Lee, BI
AF Han, Eunyoung
   Park, Jinse
   Kim, Haeyu
   Jo, Geunyeol
   Do, Hwan-Kwon
   Lee, Byung In
TI Cognitive Intervention with Musical Stimuli Using Digital Devices on
   Mild Cognitive Impairment: A Pilot Study
SO HEALTHCARE
LA English
DT Article
DE mild cognitive impairment; music therapy; executive function; technology
ID ALZHEIMERS-DISEASE; DEMENTIA; THERAPY; MULTICENTER; PERSPECTIVE;
   DONEPEZIL; BEHAVIOR; BLIND; RISK
AB The effect of music therapy on cognitive function has been widely reported; however, its clinical implications remain controversial. Performing therapeutic musical activities in groups using individualized instruments can help overcome the issues of engagement and compliance. We aimed to evaluate the effect of a cognitive intervention with musical stimuli using digital devices on mild cognitive impairment (MCI). In this prospective study, 24 patients with MCI (intervention group, 12; and control group, 12) were enrolled. We developed an electronic device with musical instruments and the Song-based Cognitive Stimulation Therapy protocol (SongCST). Patients in the intervention group underwent a 10-week cognitive intervention involving musical stimuli generated by our device. Effect of the intervention on cognitive function was evaluated by the Mini-Mental State Examination-Dementia Screening (MMSE-DS), Montreal Cognitive Assessment-Korean (MOCA-K), and Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB). In the intervention group, MMSE-DS and MOCA-K scores improved significantly after the 10-week intervention. The changes in MOCA-K and CDR-SB scores were significantly different between the intervention and control groups. Our study showed that music therapy with digital devices has a positive effect on the executive function and overall disease severity in patients with MCI. Our study can facilitate individualization of music therapy using digital devices in groups.
C1 [Han, Eunyoung] Ewha Womans Univ, Grad Sch, Dept Mus Therapy, Seoul 52, South Korea.
   [Han, Eunyoung; Park, Jinse; Lee, Byung In] Inje Univ, Haeundae Paik Hosp, Dept Neurol, Busan 50834, South Korea.
   [Kim, Haeyu] Inje Univ, Haeundae Paik Hosp, Dept Neurol Surg, Busan 50834, South Korea.
   [Jo, Geunyeol; Do, Hwan-Kwon] Inje Univ, Haeundae Paik Hosp, Dept Phys Med & Rehabil, Busan 50834, South Korea.
C3 Ewha Womans University; Inje University; Inje University; Inje
   University
RP Park, J (corresponding author), Inje Univ, Haeundae Paik Hosp, Dept Neurol, Busan 50834, South Korea.
EM heyewha@gmail.com; loca99@paik.ac.kr; hykim080356@gmail.com;
   hprm@paik.ac.kr; satirev83@gmail.com; BILEE@paik.ac.kr
OI Park, Jinse/0000-0001-8738-5422; Kim, Hae Yu/0000-0002-6588-050X; HAN,
   EUN-YOUNG/0000-0001-5627-7664
FU Ministry of Trade, Industry and Energy [100777706]
FX Ministry of Trade, Industry and Energy: 100777706.
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NR 49
TC 7
Z9 7
U1 7
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAR
PY 2020
VL 8
IS 1
AR 45
DI 10.3390/healthcare8010045
PG 13
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA LA1MZ
UT WOS:000523720400062
PM 32106559
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Chandler, MJ
   Parks, AC
   Marsiske, M
   Rotblatt, LJ
   Smith, GE
AF Chandler, M. J.
   Parks, A. C.
   Marsiske, M.
   Rotblatt, L. J.
   Smith, G. E.
TI Everyday Impact of Cognitive Interventions in Mild Cognitive Impairment:
   a Systematic Review and Meta-Analysis
SO NEUROPSYCHOLOGY REVIEW
LA English
DT Review
DE Mild Cognitive Impairment; Cognitive intervention; Activities of daily
   living; Quality of life; systematic review; meta-analysis
ID RANDOMIZED CONTROLLED-TRIAL; HEALTHY OLDER-ADULTS; DAILY LIVING SCALE;
   ALZHEIMERS-DISEASE; NONPHARMACOLOGICAL INTERVENTIONS; INSTRUMENTAL
   ACTIVITIES; CHINESE VERSION; WORKING GROUP; DOUBLE-BLIND; MEMORY
AB Cognitive interventions in Mild Cognitive Impairment (MCI) seek to ameliorate cognitive symptoms in the condition. Cognitive interventions may or may not generalize beyond cognitive outcomes to everyday life. This systematic review and meta-analysis sought to assess the effect of cognitive interventions compared to a control group in MCI on generalizability outcome measures [activities of daily living (ADLs), mood, quality of life (QOL), and metacognition] rather than cognitive outcomes alone. PRISMA guidelines were followed. MEDLINE and PsychInfo were utilized as data sources to locate references related to cognitive interventions in individuals with MCI. The cognitive intervention study was required to have a control or alternative treatment comparison group to be included. Thirty articles met criteria, including six computerized cognitive interventions, 14 therapist-based interventions, and 10 multimodal (i.e., cognitive intervention plus an additional intervention) studies. Small, but significant overall median effects were seen for ADLs (d = 0.23), mood (d = 0.16), and metacognitive outcomes (d = 0.30), but not for QOL (d = 0.10). Computerized studies appeared to benefit mood (depression, anxiety, and apathy) compared to controls, while therapist-based interventions and multimodal interventions had more impact on ADLs and metacognitive outcomes than control conditions. The results are encouraging that cognitive interventions in MCI may impact everyday life, but considerably more research is needed. The current review and meta-analysis is limited by our use of only PsychInfo and MEDLINE databases, our inability to read full text non-English articles, and our reliance on only published data to complete effect sizes.
C1 [Chandler, M. J.; Parks, A. C.] Mayo Clin, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
   [Marsiske, M.; Rotblatt, L. J.; Smith, G. E.] Univ Florida, Gainesville, FL USA.
C3 Mayo Clinic; State University System of Florida; University of Florida
RP Chandler, MJ (corresponding author), Mayo Clin, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
EM chandler.melanie@mayo.edu
OI Rotblatt, Lindsay/0000-0002-2854-577X
FU Patient-Centered Outcomes Research Institute (PCORI) Award
   [CER-1306-01,897]
FX Research reported in this manuscript was partially funded through a
   Patient-Centered Outcomes Research Institute (PCORI) Award
   (CER-1306-01,897). The statements in this publication are solely the
   responsibility of the authors and do not necessarily represent the views
   of the Patient-Centered Outcomes Research Institute (PCORI), its Board
   of Governors or Methodology Committee.
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NR 123
TC 88
Z9 92
U1 6
U2 61
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1040-7308
EI 1573-6660
J9 NEUROPSYCHOL REV
JI Neuropsychol. Rev.
PD SEP
PY 2016
VL 26
IS 3
SI SI
BP 225
EP 251
DI 10.1007/s11065-016-9330-4
PG 27
WC Psychology, Clinical; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA DY6AF
UT WOS:000385187000002
PM 27632385
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Bray, NW
   Pieruccini-Faria, F
   Witt, ST
   Bartha, R
   Doherty, TJ
   Nagamatsu, LS
   Almeida, QJ
   Liu-Ambrose, T
   Middleton, LE
   Bherer, L
   Montero-Odasso, M
AF Bray, Nick W.
   Pieruccini-Faria, Frederico
   Witt, Suzanne T.
   Bartha, Robert
   Doherty, Timothy J.
   Nagamatsu, Lindsay S.
   Almeida, Quincy J.
   Liu-Ambrose, Teresa
   Middleton, Laura E.
   Bherer, Louis
   Montero-Odasso, Manuel
TI Combining exercise with cognitive training and vitamin D-3 to improve
   functional brain connectivity (FBC) in older adults with mild cognitive
   impairment (MCI). Results from the SYNERGIC trial
SO GEROSCIENCE
LA English
DT Article; Early Access
DE fMRI; Mild Cognitive Impairment; Intervention; Physical Exercise;
   Randomized Controlled Trial
ID DEFAULT MODE NETWORK; ALZHEIMERS-DISEASE; PHYSICAL PERFORMANCE; ANGULAR
   GYRUS; DEMENTIA; INTERVENTION; ASSOCIATION; RESISTANCE; STRENGTH;
   REGIONS
AB Changes in functional brain connectivity (FBC) may indicate how lifestyle modifications can prevent the progression to dementia; FBC identifies areas that are spatially separate but temporally synchronized in their activation and is altered in those with mild cognitive impairment (MCI), a prodromal state between healthy cognitive aging and dementia. Participants with MCI were randomly assigned to one of five study arms. Three times per week for 20-weeks, participants performed 30-min of (control) cognitive training, followed by 60-min of (control) physical exercise. Additionally, a vitamin D-3 (10,000 IU/pill) or a placebo capsule was ingested three times per week for 20-weeks. Using the CONN toolbox, we measured FBC change (Post-Pre) across four statistical models that collapsed for and/or included some or all study arms. We conducted Pearson correlations between FBC change and changes in physical and cognitive functioning. Our sample included 120 participants (mean age: 73.89 +/- 6.50). Compared to the pure control, physical exercise (model one; p-False Discovery Rate (FDR) < 0.01 & < 0.05) with cognitive training (model two; p-FDR = < 0.001), and all three interventions combined (model four; p-FDR = < 0.01) demonstrated an increase in FBC between regions of the Default-Mode Network (i.e., hippocampus and angular gyrus). After controlling for false discovery rate, there were no significant correlations between change in connectivity and change in cognitive or physical function. Physical exercise alone appears to be as efficacious as combined interventional strategies in altering FBC, but implications for behavioral outcomes remain unclear.
C1 [Bray, Nick W.] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB T2N 1N4, Canada.
   [Bray, Nick W.] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 1N4, Canada.
   [Bray, Nick W.; Pieruccini-Faria, Frederico; Montero-Odasso, Manuel] Parkwood Inst, Lawson Hlth Res Inst, Gait & Brain Lab, 550 Wellington Rd, Room A3-116, London, ON N6C 0A7, Canada.
   [Pieruccini-Faria, Frederico; Montero-Odasso, Manuel] Western Univ, Schulich Sch Med & Dent, Dept Med, Div Geriatr Med, London, ON N6A 5C1, Canada.
   [Witt, Suzanne T.] Western Univ, BrainsCAN, London, ON N6A 3K7, Canada.
   [Bartha, Robert] Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON N6A 5C1, Canada.
   [Bartha, Robert] Western Univ, Robarts Res Inst, London, ON N6A 5B7, Canada.
   [Doherty, Timothy J.] Western Univ, Schulich Sch Med & Dent, Dept Clin Neurol Sci, London, ON N6A 5C1, Canada.
   [Doherty, Timothy J.] Western Univ, Schulich Sch Med & Dent, Dept Phys Med & Rehabil, London, ON N6A 5C1, Canada.
   [Nagamatsu, Lindsay S.] Western Univ, Fac Hlth Sci, Sch Kinesiol, London, ON N6G 2V4, Canada.
   [Almeida, Quincy J.] Wilfrid Laurier Univ, Fac Sci, Dept Kinesiol & Phys Educ, Waterloo, ON N2L 3C5, Canada.
   [Liu-Ambrose, Teresa] Univ British Columbia, Dept Phys Therapy, Vancouver, BC V6T 1Z3, Canada.
   [Liu-Ambrose, Teresa] Vancouver Coastal Hlth Res Inst, Ctr Aging SMART Vancouver Coastal Hlth, Vancouver, BC, Canada.
   [Middleton, Laura E.] Univ Waterloo, Dept Kinesiol & Hlth Sci, Waterloo, ON N2L 3G1, Canada.
   [Bherer, Louis] Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.
   [Bherer, Louis] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada.
   [Montero-Odasso, Manuel] Western Univ, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON N6A 5C1, Canada.
C3 University of Calgary; University of Calgary; Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Western University (University of Western Ontario);
   Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Western University (University of Western Ontario);
   Western University (University of Western Ontario); Wilfrid Laurier
   University; University of British Columbia; Vancouver Coastal Health
   Research Institute; University of Waterloo; Universite de Montreal;
   Universite de Montreal; Western University (University of Western
   Ontario)
RP Bray, NW (corresponding author), Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB T2N 1N4, Canada.; Bray, NW (corresponding author), Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 1N4, Canada.; Bray, NW; Montero-Odasso, M (corresponding author), Parkwood Inst, Lawson Hlth Res Inst, Gait & Brain Lab, 550 Wellington Rd, Room A3-116, London, ON N6C 0A7, Canada.; Montero-Odasso, M (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Med, Div Geriatr Med, London, ON N6A 5C1, Canada.; Montero-Odasso, M (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON N6A 5C1, Canada.
EM nicholas.bray@ucalgary.ca; mmontero@uwo.ca
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NR 110
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD 2023 MAY 10
PY 2023
DI 10.1007/s11357-023-00805-6
EA MAY 2023
PG 19
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA F7OJ9
UT WOS:000984199000001
PM 37162700
OA Green Published
DA 2023-08-17
ER

PT J
AU Park, EA
   Jung, AR
   Lee, KA
AF Park, Eun-A
   Jung, Ae-Ri
   Lee, Kyoung-A
TI The Humanoid Robot Sil-Bot in a Cognitive Training Program for
   Community-Dwelling Elderly People with Mild Cognitive Impairment during
   the COVID-19 Pandemic: A Randomized Controlled Trial
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE mild cognitive impairment (MCI); humanoid robots; randomized controlled
   trial; cognition; depression
ID SUBJECTIVE MEMORY COMPLAINTS; OLDER-ADULTS; CORTICAL THICKNESS;
   VIRTUAL-REALITY; DEPRESSION; DEMENTIA; CARE; PREVENTION; SUPPORT;
   DECLINE
AB Background: Mild cognitive impairment (MCI) is a stage preceding dementia, and early intervention is critical. This study investigated whether multi-domain cognitive training programs, especially robot-assisted training, conducted 12 times, twice a week for 6 weeks can improve cognitive function and depression decline in community-dwelling older adults with mild cognitive impairment (MCI). Methods: A randomized controlled trial was conducted with 135 volunteers without cognitive impairment aged 60 years old or older. Participants were first randomized into two groups. One group consisted of 90 participants who would receive cognitive training and 45 who would not receive any training (NI). The cognitive training group was randomly divided into two groups, 45 who received traditional cognitive training (TCT) and 45 who received robot-assisted cognitive training (RACT). The training for both groups consisted of a daily 60 min session, twice a week for six weeks. Results: RACT participants had significantly greater post-intervention improvement in cognitive function (t = 4.707, p < 0.001), memory (t = -2.282, p = 0.007), executive function (t = 4.610, p < 0.001), and depression (t = -3.307, p = 0.004). TCT participants had greater post-intervention improvement in memory (t = -6.671, p < 0.001) and executive function (t = 5.393, p < 0.001). Conclusions: A 6-week robot-assisted, multi-domain cognitive training program can improve the efficiency of global cognitive function and depression during cognitive tasks in older adults with MCI, which is associated with improvements in memory and executive function.
C1 [Park, Eun-A; Jung, Ae-Ri] Bucheon Univ, Coll Nursing, Bucheon 14774, South Korea.
   [Lee, Kyoung-A] Seoul Natl Univ, Res Inst Nursing Sci, Seoul 03080, South Korea.
   [Lee, Kyoung-A] Korea Healthcare & Policy Assoc, Seoul 04555, South Korea.
C3 Seoul National University (SNU)
RP Jung, AR (corresponding author), Bucheon Univ, Coll Nursing, Bucheon 14774, South Korea.
EM pea0701@bc.ac.kr; aeri83@bc.ac.kr; tj720221@snu.ac.kr
OI Lee, Kyounga/0000-0003-0550-6070
FU Korea Institute for Robot Industry Advancement (KIRIA), Korea
FX This research received no external funding, but the research unit
   supporting this project was funded by the Korea Institute for Robot
   Industry Advancement (KIRIA), Korea.
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NR 50
TC 8
Z9 9
U1 3
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2021
VL 18
IS 15
AR 8198
DI 10.3390/ijerph18158198
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA TV6WG
UT WOS:000681860700001
PM 34360490
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Yun, SJ
   Kang, MG
   Yang, D
   Choi, Y
   Kim, H
   Oh, BM
   Seo, HG
AF Yun, Seo Jung
   Kang, Min-Gu
   Yang, Dongseok
   Choi, Younggeun
   Kim, Heejae
   Oh, Byung-Mo
   Seo, Han Gil
TI Cognitive Training Using Fully Immersive, Enriched Environment Virtual
   Reality for Patients With Mild Cognitive Impairment and Mild Dementia:
   Feasibility and Usability Study
SO JMIR SERIOUS GAMES
LA English
DT Article
DE mild cognitive impairment; dementia; virtual reality; enriched
   environment
ID ADULTS; INTERVENTION; MEMORY
AB Background: Cognitive training using virtual reality (VR) may result in motivational and playful training for patients with mild cognitive impairment and mild dementia. Fully immersive VR sets patients free from external interference and thus encourages patients with cognitive impairment to maintain selective attention. The enriched environment, which refers to a rich and stimulating environment, has a positive effect on cognitive function and mood.
   Objective: The aim of this study was to investigate the feasibility and usability of cognitive training using fully immersive VR programs in enriched environments with physiatrists, occupational therapists (OTs), and patients with mild cognitive impairment and mild dementia.
   Methods: The VR interface system consisted of a commercialized head-mounted display and a custom-made hand motion tracking module. We developed the virtual harvest and cook programs in enriched environments representing rural scenery. Physiatrists, OTs, and patients with mild cognitive impairment and mild dementia received 30 minutes of VR training to evaluate the feasibility and usability of the test for cognitive training. At the end of the test, the usability and feasibility were assessed by a self-report questionnaire based on a 7-point Likert-type scale. Response time and finger tapping were measured in patients before and after the test.
   Results: Participants included 10 physiatrists, 6 OTs, and 11 patients with mild cognitive impairment and mild dementia. The mean scores for overall satisfaction with the program were 5.75 (SD 1.00) for rehabilitation specialists and 5.64 (SD 1.43) for patients. The response time of the dominant hand in patients decreased after the single session of cognitive training using VR, but this was not statistically significant (P=.25). There was no significant change in finger tapping in either the right or left hand (P=.48 and P=.42, respectively). None of the participants reported headaches, dizziness, or any other motion sickness after the test.
   Conclusions: A fully immersive VR cognitive training program may be feasible and usable in patients with mild cognitive impairment and mild dementia based on the positive satisfaction and willingness to use the program reported by physiatrists, OTs, and patients. Although not statistically significant, decreased response time without a change in finger tapping rate may reflect a temporary increase in attention after the test. Additional clinical trials are needed to investigate the effect on cognitive function, mood, and physical outcomes.
C1 [Yun, Seo Jung; Kang, Min-Gu; Kim, Heejae; Oh, Byung-Mo; Seo, Han Gil] Seoul Natl Univ Hosp, Dept Rehabil Med, 101 Daehak Ro, Seoul 03080, South Korea.
   [Yang, Dongseok; Choi, Younggeun] Dankook Univ, Dept Comp Engn, Gyeonggi, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Dankook University
RP Seo, HG (corresponding author), Seoul Natl Univ Hosp, Dept Rehabil Med, 101 Daehak Ro, Seoul 03080, South Korea.
EM hgseo80@gmail.com
RI 최, 용근[SW융합대학 컴퓨터공학과]/HKN-2233-2023; CHOI, YOUNG GEUN/HKN-2205-2023
OI yang, dong seok/0000-0001-5891-919X; Choi,
   Younggeun/0000-0002-5634-908X; Seo, Han Gil/0000-0001-6904-7542; Yun,
   Seo Jung/0000-0002-2142-0472; Kang, Min-Gu/0000-0002-0680-9607; Oh,
   Byung-Mo/0000-0001-9353-7541; Kim, Heejae/0000-0001-6062-5246
FU Korea Radio Promotion Association
FX This study was supported by the Korea Radio Promotion Association. The
   sponsor has no role in the design, methods, data collections, analysis,
   and preparation of the paper. The authors thank Neofect (Gyeonggi-do,
   Korea) and Wysiwyg studios (Seoul, Korea) for creating the VR cognitive
   training system to meet the specifications.
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NR 33
TC 17
Z9 18
U1 10
U2 32
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY E, STE 1102, TORONTO, ON M5A 0P6, CANADA
SN 2291-9279
J9 JMIR SERIOUS GAMES
JI JMIR Serious Games
PD JUL-SEP
PY 2020
VL 8
IS 3
AR e18127
DI 10.2196/18127
PG 11
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Medical Informatics
GA OH2JX
UT WOS:000582396700003
PM 33052115
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Shin, M
   Lee, A
   Cho, AY
   Son, M
   Kim, YH
AF Shin, Minyoung
   Lee, Ahee
   Cho, A. Young
   Son, Minam
   Kim, Yun-Hee
TI Effects of Process-Based Cognitive Training on Memory in the Healthy
   Elderly and Patients with Mild Cognitive Impairment: A Randomized
   Controlled Trial
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Aging; Mild cognitive impairment; Process-based cognitive training;
   Working memory; Cognitive control
ID OLDER-ADULTS; HIPPOCAMPAL-FORMATION; KOREAN VERSION; DEPRESSION;
   PERFORMANCE; DEMENTIA; RISK; MCI; INTERVENTIONS; INTERFERENCE
AB Objective This study investigated the effects of process-based cognitive training that targets working memory and cognitive control on memory improvement in healthy elderly individuals and patients with mild cognitive impairment (MCI).
   Methods Forty healthy subjects and 40 patients with MCI were randomly assigned to either the intervention or control group. The intervention group received 12 sessions of designated cognitive training. The control group did not receive cognitive training. A memory test was administered pre-intervention, post-intervention, and 4 weeks after the intervention. Additional comprehensive neuropsychological tests were also administered including a depression scale questionnaire.
   Results Performance in attention and working memory, which are directly related to the training domains, and global cognitive function were improved in the intervention group after training. In memory tests, interference by irrelevant stimuli was reduced and recognition memory was improved after the intervention. Furthermore, cognitive training ameliorated depressive symptoms. These training effects were not dependent on MCI status.
   Conclusion Process-based cognitive training that targets working memory and cognitive control effectively improves memory processes including retrograde interference and recognition, as well as depressive symptoms associated with aging in healthy elderly individuals and patients with MCI.
C1 [Shin, Minyoung; Lee, Ahee; Cho, A. Young; Son, Minam; Kim, Yun-Hee] Sungkyunkwan Univ, Ctr Prevent & Rehabil, Samsung Med Ctr, Heart Vasc & Stroke Inst,Sch Med,Dept Phys & Reha, 81 Irwon Ro, Seoul 06351, South Korea.
   [Shin, Minyoung] Yongmoon Grad Sch Counseling Psychol, Dept Counseling Psychol, Seoul, South Korea.
   [Lee, Ahee; Kim, Yun-Hee] Sungkyunkwan Univ, Dept Hlth Sci & Technol, Seoul, South Korea.
   [Kim, Yun-Hee] Sungkyunkwan Univ, Dept Med Device Management, Digital Healthcare, SAIHST, 81 Irwon Ro, Seoul 06351, South Korea.
   [Kim, Yun-Hee] Sungkyunkwan Univ, Dept Res, Digital Healthcare, SAIHST, 81 Irwon Ro, Seoul 06351, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Sungkyunkwan University (SKKU); Sungkyunkwan
   University (SKKU)
RP Kim, YH (corresponding author), Sungkyunkwan Univ, Ctr Prevent & Rehabil, Samsung Med Ctr, Heart Vasc & Stroke Inst,Sch Med,Dept Phys & Reha, 81 Irwon Ro, Seoul 06351, South Korea.; Kim, YH (corresponding author), Sungkyunkwan Univ, Dept Med Device Management, Digital Healthcare, SAIHST, 81 Irwon Ro, Seoul 06351, South Korea.; Kim, YH (corresponding author), Sungkyunkwan Univ, Dept Res, Digital Healthcare, SAIHST, 81 Irwon Ro, Seoul 06351, South Korea.
EM yun1225.kim@samsung.com
RI Kim, Yun Hee/F-4600-2014; Kim, Yun-Hee/GVS-6426-2022
OI Shin, Minyoung/0000-0002-9742-9510
FU Institute for Information & Communications Technology Promotion (IITP) -
   Korea government (MSIT); Korea Evaluation Institute of Industrial
   Technology (KEIT) - Korean government (MOTIE) [10067221]; Korea
   Evaluation Institute of Industrial Technology (KEIT) [10067221] Funding
   Source: Korea Institute of Science & Technology Information (KISTI),
   National Science & Technology Information Service (NTIS)
FX This work was supported by Institute for Information & Communications
   Technology Promotion (IITP) grant funded by the Korea government (MSIT)
   (Development for Humancare Contents) and Korea Evaluation Institute of
   Industrial Technology (KEIT) grant funded by the Korean government
   (MOTIE) (No.10067221).
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NR 48
TC 2
Z9 2
U1 3
U2 20
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD AUG
PY 2020
VL 17
IS 8
BP 751
EP 761
DI 10.30773/pi.2019.0225
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA NR5BK
UT WOS:000571577300004
PM 32777923
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Barban, F
   Mancini, M
   Cercignani, M
   Adriano, F
   Perri, R
   Annicchiarico, R
   Carlesimo, GA
   Ricci, C
   Lombardi, MG
   Teodonno, V
   Serra, L
   Giulietti, G
   Fadda, L
   Federici, A
   Caltagirone, C
   Bozzali, M
AF Barban, Francesco
   Mancini, Matteo
   Cercignani, Mara
   Adriano, Fulvia
   Perri, Roberta
   Annicchiarico, Roberta
   Carlesimo, Giovanni Augusto
   Ricci, Claudia
   Lombardi, Maria Giovanna
   Teodonno, Valeria
   Serra, Laura
   Giulietti, Giovanni
   Fadda, Lucia
   Federici, Alessia
   Caltagirone, Carlo
   Bozzali, Marco
TI A Pilot Study on Brain Plasticity of Functional Connectivity Modulated
   by Cognitive Training in Mild Alzheimer's Disease and Mild Cognitive
   Impairment
SO BRAIN SCIENCES
LA English
DT Article
DE Alzheimer's disease; mild cognitive impairment; neural plasticity; DMN;
   connectomics; fMRI; graph theory; cognitive training
ID DEFAULT-MODE NETWORK; RESTING-STATE NETWORKS; TEMPORAL-LOBE ATROPHY;
   NORMATIVE DATA; ANATOMY; ASSOCIATION; BIOMARKERS; PEOPLE; SCALE; SPAN
AB Alzheimer's disease (AD) alters the functional connectivity of the default mode network (DMN) but also the topological properties of the functional connectome. Cognitive training (CT) is a tool to slow down AD progression and is likely to impact on functional connectivity. In this pilot study, we aimed at investigating brain functional changes after a period of CT and active control (AC) in a group of 26 subjects with mild AD (mAD), 26 with amnestic mild cognitive impairment (aMCI), and a control group of 29 healthy elderly (HE) people. They all underwent a CT and AC in a counterbalanced order following a crossover design. Resting-state functional MRI and neuropsychological testing were acquired before and after each period. We tested post-CT and post-AC changes of cognitive abilities, of the functional connectivity of the DMN, and of topological network properties derived from graph theory and network-based statistics. Only CT produced functional changes, increasing the functional connectivity of the posterior DMN in all three groups. mAD also showed functional changes in the medial temporal lobe and topological changes in the anterior cingulum, whereas aMCI showed more widespread topological changes involving the frontal lobes, the cerebellum and the thalamus. Our results suggest specific functional connectivity changes after CT for aMCI and mAD.
C1 [Barban, Francesco; Adriano, Fulvia; Perri, Roberta; Annicchiarico, Roberta; Carlesimo, Giovanni Augusto; Ricci, Claudia; Lombardi, Maria Giovanna; Teodonno, Valeria; Fadda, Lucia; Federici, Alessia; Caltagirone, Carlo] IRCCS Santa Lucia Fdn, Clin & Behav Neurol Lab, I-00179 Rome, Italy.
   [Barban, Francesco; Adriano, Fulvia; Serra, Laura; Giulietti, Giovanni; Bozzali, Marco] IRCCS Santa Lucia Fdn, Neuroimaging Lab, I-00179 Rome, Italy.
   [Barban, Francesco] Humboldt Univ, Berlin Sch Mind & Brain, D-10117 Berlin, Germany.
   [Mancini, Matteo] Univ Rome Roma Tre, Dept Engn, I-00146 Rome, Italy.
   [Cercignani, Mara] Brighton & Sussex & Med Sch, Clin Imaging Sci Ctr, Brighton BN1 9RR, E Sussex, England.
   [Carlesimo, Giovanni Augusto; Fadda, Lucia; Caltagirone, Carlo] Univ Tor Vergata, Dept Syst Med, I-00173 Rome, Italy.
C3 IRCCS Santa Lucia; IRCCS Santa Lucia; Humboldt University of Berlin;
   Roma Tre University; University of Brighton; University of Sussex;
   University of Rome Tor Vergata
RP Barban, F (corresponding author), IRCCS Santa Lucia Fdn, Clin & Behav Neurol Lab, I-00179 Rome, Italy.; Barban, F (corresponding author), IRCCS Santa Lucia Fdn, Neuroimaging Lab, I-00179 Rome, Italy.; Barban, F (corresponding author), Humboldt Univ, Berlin Sch Mind & Brain, D-10117 Berlin, Germany.
EM francesco.barban@gmail.com; ingmatteomancini@gmail.com;
   m.cercignani@bsms.ac.uk; f.adriano@hsantalucia.it;
   r.perri@hsantalucia.it; r.annicchiarico@hsantalucia.it;
   memolab@hsantalucia.it; c.ricci@hsantalucia.it;
   mg.lombardi@hsantalucia.it; vteodonno@gmail.com; l.serra@hsantalucia.it;
   g.giulietti@hsantalucia.it; l.fadda@hsantalucia.it;
   a.federici@hsantalucia.it; c.caltagirone@hsantalucia.it;
   m.bozzali@hsantalucia.it
RI Mancini, Matteo/K-6627-2016; Adriano, Fulvia/E-6805-2017; Bozzali,
   Marco/AAC-1031-2022; Giulietti, Giovanni/D-2771-2009; Serra,
   Laura/K-5637-2016
OI Mancini, Matteo/0000-0001-7194-4568; Adriano,
   Fulvia/0000-0001-5423-3254; Serra, Laura/0000-0002-2717-1286;
   Cercignani, Mara/0000-0002-4550-2456; Bozzali, Marco/0000-0002-0568-2026
FU Italian Ministry of Health grant for young researchers to Francesco
   Barban [GR-2010-2313174]
FX This work was supported by an Italian Ministry of Health grant for young
   researchers to Francesco Barban (# GR-2010-2313174). The authors
   acknowledge all the participants and their caregivers for their
   collaboration in this project.
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NR 84
TC 34
Z9 35
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD MAY
PY 2017
VL 7
IS 5
AR 50
DI 10.3390/brainsci7050050
PG 22
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EZ0FT
UT WOS:000404377500006
PM 28468232
OA Green Published, Green Submitted, Green Accepted, gold
DA 2023-08-17
ER

PT J
AU Donnezan, LC
   Perrot, A
   Belleville, S
   Bloch, F
   Kemoun, G
AF Donnezan, Laure Combourieu
   Perrot, Alexandra
   Belleville, Sylvie
   Bloch, Frederic
   Kemoun, Gilles
TI Effects of simultaneous aerobic and cognitive training on executive
   functions, cardiovascular fitness and functional abilities in older
   adults with mild cognitive impairment
SO MENTAL HEALTH AND PHYSICAL ACTIVITY
LA English
DT Article
DE MCI; Simultaneous training; Aerobic and cognitive training; Executive
   function; Gait
ID ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; INTERVENTIONS; DEMENTIA;
   EXERCISE; RISK; PLASTICITY; WALKING; PEOPLE
AB People with Mild Cognitive Impairment (MCI) experience cognitive decline and reduction in their motor capacities. Several programs have used physical or cognitive stimulation with encouraging results for the cognitive performances; however, none have studied both together. The goal of this study is to compare the benefits of simultaneous training with the results of single cognitive and physical training on executive, cardiorespiratory and walking measures in order to assess a potential sur-additive effect.
   Sixty-nine older adults diagnosed with MCI were randomized to simultaneous cognitive and physical training (PCT), physical training only (PT), cognitive training only (CT) or a no-intervention control group (C). Training was provided through 24 1-h sessions. Participants completed a battery of neuropsychological tests that targeted executive functions both before and after training sessions. They also underwent the Rockport test to measure cardiorespiratory fitness, along with a battery of walking tests. The tests were repeated six months after the training programs had ended to assess long-term effects.
   A repeated measure ANOVA and planned comparisons revealed significant improvements in executive control and walking capacities in the three training programs. In particular, the PCT groups showed significant improvements in a larger number of outcomes: 8 tests showed increased gains in the PCT group compared with 2 in the PT group and 2 in the CT group.
   It is more advantageous to provide cognitive and physical activity training simultaneously than in isolation. Gains in cognitive and motor domains could allow a better adaption to situations that require the recruitment of multiple resources.
C1 [Donnezan, Laure Combourieu; Perrot, Alexandra] Univ Paris Sud, EA 4532, F-91405 Orsay, France.
   [Belleville, Sylvie] Inst Univ Geriatrie Montreal, Ctr Rech, Montreal, PQ, Canada.
   [Bloch, Frederic] Univ Picardie Jules Verne, Univ Hosp Amiens Picardie, Dept Geriatr Med, Amiens, France.
   [Kemoun, Gilles] Univ Poitiers, Lab Mobilite Vieillissement Exercice MOVE, EA 3813, Poitiers, France.
C3 UDICE-French Research Universities; Universite Paris Saclay; Universite
   de Montreal; Picardie Universites; Universite de Picardie Jules Verne
   (UPJV); CHU Amiens; Universite de Poitiers
RP Donnezan, LC (corresponding author), 35 Rue Paris, F-92110 Clichy, France.
EM laurecombourieu@yahoo.fr
OI Perrot, Alexandra/0000-0003-1246-2221
FU Broca Hospital; seniors' club of the Mairie de Paris (Paris City Hall);
   SBT; Decathlon
FX The authors would like to thank the Broca Hospital, the seniors' club of
   the Mairie de Paris (Paris City Hall), SBT and Decathlon for supporting
   this study.
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NR 46
TC 43
Z9 44
U1 5
U2 36
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1755-2966
EI 1878-0199
J9 MENT HEALTH PHYS ACT
JI Ment. Health Phys. Act.
PD OCT
PY 2018
VL 15
BP 78
EP 87
DI 10.1016/j.mhpa.2018.06.001
PG 10
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA HE0CA
UT WOS:000452933200014
OA Green Submitted
DA 2023-08-17
ER

PT J
AU Lin, FV
   Heffner, K
   Gevirtz, R
   Zhang, ZW
   Tadin, D
   Porsteinsson, A
AF Lin, Feng, V
   Heffner, Kathi
   Gevirtz, Richard
   Zhang, Zhengwu
   Tadin, Duje
   Porsteinsson, Anton
TI Targeting autonomic flexibility to enhance cognitive training outcomes
   in older adults with mild cognitive impairment: study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE Autonomic nervous system; Central autonomic network; Mild cognitive
   impairment; Biofeedback training
ID HEART-RATE-VARIABILITY; DIRECT-CURRENT STIMULATION; VERBAL-LEARNING
   TEST; ALZHEIMERS-DISEASE; NEUROVISCERAL INTEGRATION; SELECTIVE
   ATTENTION; BRAIN; BIOFEEDBACK; STRESS; ASSOCIATION
AB Importance: Cognitive training with components that can further enhance the transferred and long-term effects and slow the progress of dementia is needed for preventing dementia.
   Objective: The goal of the study is to test whether improving autonomic nervous system (ANS) flexibility via a resonance frequency breathing (RFB) training will strengthen the effects of a visual speed of processing (VSOP) cognitive training on cognitive and brain function, and slow the progress of dementia in older adults with mild cognitive impairment (MCI).
   Design: Stage II double-blinded randomized controlled trial. The study was prospectively registered at ClinicalTrials.gov , with registration approved on 21 August 2020 (No. NCT04522791).
   Setting: Study-related appointments will be conducted on-site at University of Rochester Medical Center locations. Data collection will be conducted from August 2020 to February 2025.
   Participants: Older adults with MCI (n = 114) will be randomly assigned to an 8-week combined intervention (RFB+VSOP), VSOP with guided imagery relaxation (IR) control, and a IR-only control, with periodical booster training sessions at follow-ups. Mechanistic and distal outcomes include ANS flexibility, measured by heart rate variability, and multiple markers of dementia progress. Data will be collected across a 14-month period.
   Discussion: This will be among the first RCTs to examine in older persons with MCI a novel, combined intervention targeting ANS flexibility, an important contributor to overall environmental adaptation, with an ultimate goal for slowing neurodegeneration.
C1 [Lin, Feng, V] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA USA.
   [Lin, Feng, V] Stanford Univ, Wu Tsai Neurosci Inst, Stanford, CA 94305 USA.
   [Lin, Feng, V; Heffner, Kathi] Univ Rochester, Med Ctr, Sch Nursing, Elaine C Hubbard Ctr Nursing Res Aging, Rochester, NY 14642 USA.
   [Lin, Feng, V; Tadin, Duje] Univ Rochester, Dept Brain & Cognit Sci, Rochester, NY USA.
   [Heffner, Kathi] Univ Rochester, Med Ctr, Dept Med, Sch Med & Dent, Rochester, NY 14642 USA.
   [Heffner, Kathi; Porsteinsson, Anton] Univ Rochester, Med Ctr, Sch Med & Dent, Dept Psychiat, Rochester, NY 14642 USA.
   [Gevirtz, Richard] Alliant Int Univ, San Diego, CA USA.
   [Zhang, Zhengwu] Univ North Carolina Chapel Hill, Chapel Hill, NC USA.
   [Tadin, Duje] Univ Rochester, Med Ctr, Dept Neurosci, Sch Med & Dent, Rochester, NY 14642 USA.
C3 Stanford University; Stanford University; University of Rochester;
   University of Rochester; University of Rochester; University of
   Rochester; Alliant International University; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine; University of Rochester
RP Heffner, K (corresponding author), Univ Rochester, Med Ctr, Sch Nursing, Elaine C Hubbard Ctr Nursing Res Aging, Rochester, NY 14642 USA.; Heffner, K (corresponding author), Univ Rochester, Med Ctr, Dept Med, Sch Med & Dent, Rochester, NY 14642 USA.; Heffner, K (corresponding author), Univ Rochester, Med Ctr, Sch Med & Dent, Dept Psychiat, Rochester, NY 14642 USA.
EM Kathi_heffner@urmc.rochester.edu
OI Heffner, Kathi/0000-0003-1095-1873; Lin, Feng Vankee/0000-0003-1945-0362
FU National Institute of Nursing Research (NINR) of the National Institute
   of Health [R01NR015452]
FX This research is funded by the National Institute of Nursing Research
   (NINR) of the National Institute of Health under grant number:
   R01NR015452 to Heffner and Lin. The funding body did not participate in
   the design of the study; in the collection, analysis, and interpretation
   of the data; or in writing the manuscript. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health. Dr. Yeates Conwell
   from the University of Rochester is the independent safety monitor
   overseeing the data safety and management of the trial, approved by the
   funder.
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NR 72
TC 4
Z9 4
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD AUG 23
PY 2021
VL 22
IS 1
AR 560
DI 10.1186/s13063-021-05530-z
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA UE1QW
UT WOS:000687671800002
PM 34425878
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Tang, Y
   Zhu, ZD
   Liu, Q
   Li, F
   Yang, JW
   Li, FY
   Xing, Y
   Jia, JP
AF Tang, Yi
   Zhu, Zude
   Liu, Qing
   Li, Fang
   Yang, Jianwei
   Li, Fangyu
   Xing, Yi
   Jia, Jianping
TI The efficacy of Cognitive training in patients with VAsCular Cognitive
   Impairment, No dEmentia (the Cog-VACCINE study): study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE Cognitive training; Magnetic resonance imaging; Neuroplasticity; No
   dementia; Protocol; Randomized controlled clinical trial; Vascular
   cognitive impairment
ID SMALL VESSEL DISEASE; ALZHEIMERS-DISEASE; PREVALENCE; MEMORY;
   PLASTICITY; DISORDERS; STATEMENT; ADULTS; BRAIN
AB Background: Vascular cognitive impairment, no dementia (VCIND) refers to cognitive deficits associated with underlying vascular causes that fall short of a dementia diagnosis. There is currently no treatment for VCIND. Computerized cognitive training, which has significantly improved cognitive function in healthy older adults and patients with cognitive impairment has not yet been applied to VCIND.
   Methods/Design: The proposed study is a three-center, double-blinded, randomized controlled trial that will include 60 patients with VCIND. The patients will be randomized to either a training or a control group. The intervention is internet-based cognitive training performed for 30 min over 35 sessions. Neuropsychological assessment and functional and structural MRI will be performed before and after 7 weeks training. Primary outcomes are global cognitive function and executive function. Secondary outcome measures are neuroplasticity changes measured by functional and structural MRI.
   Discussion: Applying an internet-based, multi-domain, adaptive program, this study aims to assess whether cognitive training improves cognitive abilities and neural plasticity in patients with subcortical VCIND. In addition to the comprehensive assessment of the participants by neuropsychological tests, cerebrovascular risk factors and apolipoprotein E genotyping, neuroplasticity will be used as an evaluation outcome in this study for, to our knowledge, the first time. The combination of functional and structural MRI and neuropsychological tests will have strong sensitivity in evaluating the effects of cognitive training and will also reveal the underlying mechanisms at work.
C1 [Tang, Yi; Liu, Qing; Yang, Jianwei; Li, Fangyu; Xing, Yi; Jia, Jianping] Capital Med Univ, Xuan Wu Hosp, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China.
   [Zhu, Zude] Jiangsu Normal Univ, Collaborat Innovat Ctr Language Competence, Xuzhou, Jiangsu, Peoples R China.
   [Li, Fang] Capital Med Univ, Fu Xing Hosp, Dept Geriatr Med, Beijing, Peoples R China.
   [Jia, Jianping] Capital Med Univ, Beijing Friendship Hosp, Dept Neurol, Beijing, Peoples R China.
C3 Capital Medical University; Jiangsu Normal University; Capital Medical
   University; Capital Medical University
RP Tang, Y; Jia, JP (corresponding author), Capital Med Univ, Xuan Wu Hosp, Dept Neurol, 45 Changchun St, Beijing 100053, Peoples R China.
EM tangyixw@163.com; jiajp@vip.126.com
OI Jia, Jianping/0000-0003-4624-0336
FU Beijing Municipal Science & Technology Commission [Z151100004015078];
   Beijing Talents Fund [2014000021223ZK31]; National Natural Science
   Foundation of China [31571156]
FX This trial is supported by Beijing Municipal Science & Technology
   Commission (Z151100004015078), Beijing Talents Fund (2014000021223ZK31),
   and the National Natural Science Foundation of China (31571156).
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NR 38
TC 11
Z9 12
U1 1
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD AUG 5
PY 2016
VL 17
AR 392
DI 10.1186/s13063-016-1523-x
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DS9BS
UT WOS:000381077700001
PM 27496126
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Tappen, RM
   Hain, D
AF Tappen, Ruth M.
   Hain, Debra
TI The Effect of In-Home Cognitive Training on Functional Performance of
   Individuals with Mild Cognitive Impairment and Early-Stage Alzheimer's
   Disease
SO RESEARCH IN GERONTOLOGICAL NURSING
LA English
DT Article
ID MINI-MENTAL-STATE; PROSPECTIVE MEMORY; OLDER-ADULTS; DEMENTIA;
   EDUCATION; SCORES; SCALE; AGE
AB This intervention study compared an in-home cognitive training program to life story interview in 68 individuals with mild cognitive impairment or early-stage Alzheimer's disease. Family caregivers participated in sessions and reinforced learning between sessions. Analyses of covariance controlling for baseline levels were conducted. In comparison with the life story group, participants in the cognitive training group demonstrated significant improvement in all face-name association measures, several of the money-related tasks, and one of two event-related memory tasks. There were no differences in language outcomes or caregiver ratings of functional tasks except shopping. Caregivers in the life story group reported higher perceived satisfaction from being a caregiver. Comparison with earlier studies suggests in-home training is modestly more effective than office-based intervention. Results suggest that improvements are related to specific training and do not generalize to other tasks. Focusing on tasks of critical significance to participant and caregiver is recommended.
C1 [Tappen, Ruth M.; Hain, Debra] Florida Atlantic Univ, Christine E Lynn Coll Nursing, Boca Raton, FL 33431 USA.
   [Hain, Debra] Cleveland Clin Florida, Dept Nephrol, Weston, FL USA.
C3 State University System of Florida; Florida Atlantic University;
   Cleveland Clinic Foundation
RP Tappen, RM (corresponding author), Florida Atlantic Univ, Christine E Lynn Coll Nursing, 777 Glades Rd,NU84,Room 307, Boca Raton, FL 33431 USA.
EM rtappen@fau.edu
FU Alzheimer's Association
FX The authors have disclosed no potential conflicts of interest, financial
   or otherwise. The study entitled "The Effect of In-Home Cognitive
   Training on Functional Performance of Individuals with Mild Cognitive
   Impairment and Early-Stage Alzheimer's Disease" was funded by the
   Alzheimer's Association.
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NR 38
TC 22
Z9 23
U1 1
U2 33
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 1940-4921
EI 1938-2464
J9 RES GERONTOL NURS
JI Res. Gerontol. Nurs.
PD JAN-FEB
PY 2014
VL 7
IS 1
BP 14
EP 24
DI 10.3928/19404921-20131009-01
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AH2UB
UT WOS:000335975700004
PM 24131045
DA 2023-08-17
ER

PT J
AU Zhao, XY
   Huang, XX
   Cai, Y
   Cao, T
   Wan, QQ
AF Zhao, Xiaoyan
   Huang, Xiuxiu
   Cai, Ying
   Cao, Ting
   Wan, Qiaoqin
TI The relative effectiveness of different combination modes for exercise
   and cognitive training on cognitive function in people with mild
   cognitive impairment or Alzheimer's disease: a network meta-analysis
SO AGING & MENTAL HEALTH
LA English
DT Review
DE Exercise; cognitive training; cognitive function; cognitive impairment;
   network meta-analysis
ID NEUROTROPHIC FACTOR BDNF; QUALITY-OF-LIFE; PHYSICAL-EXERCISE;
   OLDER-ADULTS; DEMENTIA; INTERVENTIONS; DIAGNOSIS; BALANCE; SENIORS;
   MEMORY
AB Objectives To compare and rank the relative effectiveness of different modes for exercise combined cognitive training (ECT) in people with Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI). Methods We searched PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, SPORTDiscus, PsycInfo, and OpenGrey systematically from inception to May 2020. Studies were included that met the inclusion criteria: randomized controlled trials, involving people with MCI or dementia, performing ECT without other interventions, and assessing global cognitive function, memory function, and executive function. Pairwise and network meta-analyses were performed using a random effects model. Results We included 20 articles from 16 studies with 1180 participants. For global cognition, separate modality had the highest probability of being the optimal approach (the surface under the cumulative ranking curve (SUCRA) value = 77.5%). For memory function, the interactive mode had the greatest probability of being the best choice (SUCRA = 84.7%). Concerning executive function, the dual-task modality and separate modality had similar SUCRA values. Subgroup analysis revealed no differences for the relative effectiveness of ECT among people with MCI or among all participants. Conclusions Separate and interactive combination modality had the highest probability of being the most effective mode for overall cognition and memory performance. However, the evidence is insufficient to reveal the best combination mode for executive function. Supplemental data for this article is available online at https://doi.org/10.1080/13607863.2022.2026879 .
C1 [Zhao, Xiaoyan; Huang, Xiuxiu; Cai, Ying; Cao, Ting; Wan, Qiaoqin] Peking Univ, Sch Nursing, Beijing, Peoples R China.
C3 Peking University
RP Wan, QQ (corresponding author), Peking Univ, Sch Nursing, Beijing, Peoples R China.
EM qqwan05@163.com
RI Huang, Xiuxiu/AAM-4920-2021
OI Huang, Xiuxiu/0000-0002-5065-9087
FU National Natural Science Foundation of China [81871854]
FX This work was supported by the National Natural Science Foundation of
   China (81871854).
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NR 70
TC 3
Z9 3
U1 3
U2 25
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD DEC 2
PY 2022
VL 26
IS 12
BP 2328
EP 2338
DI 10.1080/13607863.2022.2026879
EA JAN 2022
PG 11
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 6D6VY
UT WOS:000744352200001
PM 35037809
DA 2023-08-17
ER

PT J
AU Martin, D
   Mohan, A
   Alonzo, A
   Sachdev, P
   Brodaty, H
   Loo, C
AF Martin, Donel
   Mohan, Adith
   Alonzo, Angelo
   Sachdev, Perminder
   Brodaty, Henry
   Loo, Colleen
TI Transcranial Direct Current Stimulation (tDCS) Combined with
   Computerized Cognitive Training to Enhance Memory in People with
   Amnestic Mild Cognitive Impairment (aMCI): Preliminary Results from a
   Pilot Randomized Controlled Trial
SO BIOLOGICAL PSYCHIATRY
LA English
DT Meeting Abstract
CT 72nd Annual Scientific Convention and Meeting of the
   Society-of-Biological-Psychiatry (SOBP)
CY MAY 18-20, 2017
CL San Diego, CA
SP Soc Biol Psychiat
DE memory; amnestic mild cognitive impairment; transcranial direct current
   stimulation; cognitive training; clinical trial
C1 [Martin, Donel] UNSW, Sydney, NSW, Australia.
   [Mohan, Adith; Alonzo, Angelo; Loo, Colleen] UNSW, Sch Psychiat, Sydney, NSW, Australia.
   [Sachdev, Perminder; Brodaty, Henry] Ctr Hlth Brain Ageing, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; University of New South Wales
   Sydney
RI Loo, Colleen/HLX-9585-2023; Sachdev, Perminder/ABC-1137-2020; Brodaty,
   Henry/E-2753-2010
OI Sachdev, Perminder/0000-0002-9595-3220; Brodaty,
   Henry/0000-0001-9487-6617
FU Center for Healthy Brain and Ageing; Alzheimer's Australia
FX Supported By: Center for Healthy Brain and Ageing, Alzheimer's Australia
NR 0
TC 1
Z9 1
U1 1
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 15
PY 2017
VL 81
IS 10
SU S
MA 168
BP S69
EP S70
DI 10.1016/j.biopsych.2017.02.181
PG 2
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Psychiatry
GA ET5SZ
UT WOS:000400348700169
DA 2023-08-17
ER

PT J
AU Giebel, C
   Challis, D
AF Giebel, Clarissa
   Challis, David
TI Translating cognitive and everyday activity deficits into cognitive
   interventions in mild dementia and mild cognitive impairment
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE Dementia; Mild Cognitive Impairment; Cognitive Impairment; Activities of
   Daily Living; Cognitive Interventions; Translation
ID MINI-MENTAL-STATE; FACE-NAME ASSOCIATIONS; RANDOMIZED CONTROLLED-TRIAL;
   EARLY ALZHEIMERS-DISEASE; INSTRUMENTAL ACTIVITIES; OLDER-ADULTS;
   EARLY-STAGE; FINANCIAL CAPACITY; REHABILITATION; MEMORY
AB ObjectiveMild dementia is marked by deficits in cognition and everyday activities. However, few studies have translated findings from both areas of functioning into effective cognitive rehabilitation. The purpose of this review was to critically evaluate the existing literature on the type and success of interventions and on their extent of use of cognitive theory. Given the limited evidence base in this population, further insights were obtained from studies on mild cognitive impairment (MCI), which involves fewer cognitive and everyday functioning problems than dementia.
   MethodsFrom the literature searches, 11 studies on mild dementia and three studies on MCI were obtained. Studies were only included if the interventions either targeted instrumental activities of daily living or activities of daily living directly or as an outcome measure or if the interventions focused on real-life aspects not captured in the standardised daily activities. For inclusion, patients needed a diagnosis of dementia or MCI, and Mini-Mental State Examination scores had to be above 17 for mild dementia.
   ResultsThe majority of interventions indicated improved everyday activity performance in early dementia and MCI. Focusing on individual, as opposed to global, daily activities appeared to be an important determinant of intervention success in mild dementia but not in MCI. However, few attempts had been made to develop interventions grounded in evidence-based models.
   ConclusionsThis review highlights the need for further translation of the understanding of cognitive and everyday activity deficits into successful interventions for daily activities in MCI and early dementia. Hence, research is first required to link individual activities with cognitive domains. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Giebel, Clarissa; Challis, David] Univ Manchester, Manchester, Lancs, England.
C3 N8 Research Partnership; University of Manchester
RP Giebel, C (corresponding author), Univ Manchester, Manchester, Lancs, England.
EM Clarissa.giebel@manchester.ac.uk
RI Challis, David/B-9262-2008
OI Challis, David/0000-0002-6464-2286; Giebel, Clarissa/0000-0002-0746-0566
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NR 60
TC 15
Z9 15
U1 0
U2 46
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD JAN
PY 2015
VL 30
IS 1
BP 21
EP 31
DI 10.1002/gps.4170
PG 11
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA AW4WM
UT WOS:000346278300003
PM 24990546
DA 2023-08-17
ER

PT J
AU Yong, LM
   Liu, L
   Ding, T
   Yang, G
   Su, HB
   Wang, JB
   Yang, M
   Chang, JD
AF Yong, Liming
   Liu, Lei
   Ding, Ting
   Yang, Gao
   Su, Haibing
   Wang, Jibing
   Yang, Ming
   Chang, Jindong
TI Evidence of Effect of Aerobic Exercise on Cognitive Intervention in
   Older Adults With Mild Cognitive Impairment
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE aerobic exercise; mild cognitive impairment; RCTs; systematic review;
   meta-analysis
ID RANDOMIZED-CONTROLLED-TRIAL; NONPHARMACOLOGICAL INTERVENTIONS;
   METAANALYSIS; PREVALENCE; EFFICACY; MANAGEMENT; DIAGNOSIS; DISEASE;
   PEOPLE
AB This study aimed to evaluate the effectiveness of aerobic exercise as a cognitive intervention for older adults with mild cognitive impairment (MCI). The PubMed, EMBASE (Ovid), Cochrane Library, Web of Science, and Medline databases were searched from their inception until 30 April 2021. Randomized controlled trials (RCTs) examining the effects of aerobic exercise on global cognitive function in older adults with MCI were included. Ten eligible trials with acceptable methodological quality were identified. The meta-analysis results showed that aerobic exercise significantly improved the MMSE (N = 956, MD = 0.60, 95% CI: 0.28-0.92, p = 0.0003, I-2 = 31%, fixed effects model) and MoCA scores (N = 398, MD = 1.67, 95% CI. 1.18-2.15, p < 0.0001, I-2 = 37%, fixed-effects model) and overall cognitive performance in patients with MCI. The results of this study suggest that participation in regular aerobic exercise can improve cognitive function in older adults with MCI. These findings should be used with caution considering the limitations of the study.
C1 [Yong, Liming; Yang, Gao; Su, Haibing; Yang, Ming; Chang, Jindong] Southwest Univ, Sch Phys Educ, Chongqing, Peoples R China.
   [Yong, Liming; Yang, Ming; Chang, Jindong] Southwest Univ, Inst Motor Quotient, Chongqing, Peoples R China.
   [Liu, Lei; Ding, Ting] Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China.
   [Wang, Jibing] Tongji Univ, Int Coll Football, Shanghai, Peoples R China.
C3 Southwest University - China; Southwest University - China; Qingdao
   University; Tongji University
RP Yang, M; Chang, JD (corresponding author), Southwest Univ, Sch Phys Educ, Chongqing, Peoples R China.; Yang, M; Chang, JD (corresponding author), Southwest Univ, Inst Motor Quotient, Chongqing, Peoples R China.; Wang, JB (corresponding author), Tongji Univ, Int Coll Football, Shanghai, Peoples R China.
EM benwangking@126.com; yangm_swu@163.com; changlai@163.com
OI Yang, Gao/0009-0004-9117-1477; Chang, Jindong/0000-0001-6313-6245
FU Graduate Students Innovation Program of Chongqing [CYS21086];
   Fundamental Research Funds for the Central Universities of Southwest
   University [SWU1709240]; Medical Research Program Project of Chongqing
   Municipal Health and Family Planning Commission [2015ZDXM034];
   Fundamental Research Funds for the Central Universities of Tongji
   University [22120180511]
FX This study was supported by the Graduate Students Innovation Program of
   Chongqing (CYS21086), the Fundamental Research Funds for the Central
   Universities of Southwest University (SWU1709240), the Medical Research
   Program Project of Chongqing Municipal Health and Family Planning
   Commission (2015ZDXM034), and the Fundamental Research Funds for the
   Central Universities of Tongji University (22120180511).
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NR 37
TC 8
Z9 9
U1 15
U2 42
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 20
PY 2021
VL 12
AR 713671
DI 10.3389/fpsyt.2021.713671
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TT9XZ
UT WOS:000680697900001
PM 34354619
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Papaioannou, T
   Voinescu, A
   Petrini, K
   Fraser, DS
   Tuena, C
AF Papaioannou, Themis
   Voinescu, Alexandra
   Petrini, Karin
   Fraser, Danae Stanton
   Tuena, Cosimo
TI Efficacy and Moderators of Virtual Reality for Cognitive Training in
   People with Dementia and Mild Cognitive Impairment: A Systematic Review
   and Meta-Analysis
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Cognition; cognitive rehabilitation; cognitive training; dementia; mild
   cognitive impairment; virtual reality
ID QUALITY-OF-LIFE; OLDER-ADULTS; INSTRUMENTAL ACTIVITIES;
   ALZHEIMERS-DISEASE; REHABILITATION; ENVIRONMENTS; HEALTH; MEMORY; SCALE;
   FRAMEWORK
AB Background: Mild cognitive impairment (MCI) and dementia result in cognitive decline which can negatively impact everyday functional abilities and quality of life. Virtual reality (VR) interventions could benefit the cognitive abilities of people with MCI and dementia, but evidence is inconclusive.
   Objective: To investigate the efficacy of VR training on global and domain-specific cognition, activities of daily living and quality of life. To explore the influence of priori moderators (e.g., immersion type, training type) on the effects of VR training. Adverse effects of VR training were also considered.
   Methods: A systematic literature search was conducted on all major databases for randomized control trial studies. Two separate meta-analyses were performed on studies with people with MCI and dementia.
   Results: Sixteen studies with people with MCI and four studies with people with dementia were included in each meta-analysis. Results showed moderate to large effects of VR training on global cognition, attention, memory, and construction and motor performance in people with MCI. Immersion and training type were found to be significant moderators of the effect of VR training on global cognition. For people with dementia, results showed moderate to large improvements after VR training on global cognition, memory, and executive function, but a subgroup analysis was not possible.
   Conclusion: Our findings suggest that VR training is an effective treatment for both people with MCI and dementia. These results contribute to the establishment of practical guidelines for VR interventions for patients with cognitive decline.
C1 [Papaioannou, Themis; Voinescu, Alexandra; Petrini, Karin; Fraser, Danae Stanton; Tuena, Cosimo] Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England.
   [Petrini, Karin] Univ Bath, Ctr Anal Mot Entertainment Res & Applicat, Bath, Avon, England.
C3 University of Bath; University of Bath
RP Voinescu, A (corresponding author), Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England.
EM a.voinescu@bath.ac.uk
OI Voinescu, Alexandra/0000-0001-7689-335X; Petrini,
   Karin/0000-0001-5354-5600; Stanton Fraser, Danae/0000-0002-3062-731X
FU University of Bath; Centre for the Analysis of Motion, Entertainment
   Research and Applications (CAMERA 2.0) [EP/T022523/1]
FX This research was supported by the University of Bath as part of a +3
   PhD studentship held by TP. KP's research is partly funded by the Centre
   for the Analysis of Motion, Entertainment Research and Applications
   (CAMERA 2.0; EP/T022523/1).; Authors' disclosures available online
   (https://www.j-alz.com/manuscript-disclosures/21-0672r2).
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NR 134
TC 4
Z9 5
U1 15
U2 35
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2022
VL 88
IS 4
BP 1341
EP 1370
DI 10.3233/JAD-210672
PG 30
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 3V9XW
UT WOS:000842012100009
PM 35811514
OA Green Submitted
DA 2023-08-17
ER

PT J
AU Faucounau, V
   Wu, YH
   Boulay, M
   De Rotrou, J
   Rigaud, AS
AF Faucounau, V.
   Wu, Y. -H.
   Boulay, M.
   De Rotrou, J.
   Rigaud, A. -S.
TI COGNITIVE INTERVENTION PROGRAMMES ON PATIENTS AFFECTED BY MILD COGNITIVE
   IMPAIRMENT: A PROMISING INTERVENTION TOOL FOR MCI?
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Mild cognitive impairment; computer-based cognitive intervention;
   cognitive training; cognitive stimulation
ID HEALTHY OLDER-ADULTS; REHABILITATION PROGRAM; ALZHEIMERS-DISEASE;
   MEMORY; PEOPLE
AB Purpose: This paper examines and reviews studies on the efficacy of computer-based cognitive intervention programmes in the elderly affected by Mild Cognitive Impairment (MCI). MCI patients are at higher risk to progress to dementia. Recent effort has been made to slow the cognitive decline and delay the onset of dementia in this population. Method: MEDLINE sources were searched with the following subject headings: computer-based cognitive intervention, cognitive stimulation, cognitive training, aging, elderly, cognitive impairment. Selected studies were quality assessed and data extracted by two reviewers. Results: Several studies reported encouraging results on cognitive interventions programmes as a means to improve cognitive abilities and emotional states and to decrease subjective memory complaints in MCI patients. Conclusion: Though both traditional and computer-based cognitive intervention programmes seem to be effective, the computer-based ones present more advantages: 1) they could individualize the programme tailored to the patient's neuropsychological pattern and needs. 2) they permit the user to make an immediate objective comparison with data collected earlier and thus help in setting up a systematic training plan by providing instant value-free feedback. 3) they offer a possibility of a widescale dissemination.
C1 [Faucounau, V.; Wu, Y. -H.; Boulay, M.; De Rotrou, J.; Rigaud, A. -S.] Hop Broca, F-75013 Paris, France.
C3 UDICE-French Research Universities; Universite Paris Cite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Broca - APHP
RP Faucounau, V (corresponding author), Hop Broca, 54-56 Rue Pascal, F-75013 Paris, France.
EM veronique.faucounau@brc.aphp.fr
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NR 42
TC 56
Z9 59
U1 3
U2 42
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD JAN
PY 2010
VL 14
IS 1
BP 31
EP 35
DI 10.1007/s12603-010-0006-0
PG 5
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 555JE
UT WOS:000274505700006
PM 20082051
DA 2023-08-17
ER

PT J
AU Lissek, V
   Suchan, B
AF Lissek, Vanessa
   Suchan, Boris
TI Preventing dementia? Interventional approaches in mild cognitive
   impairment
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Article
DE Mild cognitive impairment (MCI); Intervention; Pharmacological
   approaches; Non-pharmacological approaches; Cognitive interventions;
   Physiological training; Nutritional supplementation; Electric
   stimulation; Psychosocial therapeutic interventions
ID GINKGO-BILOBA EXTRACT; RANDOMIZED-CONTROLLED-TRIAL; GAMMA-SECRETASE
   MODULATOR; APOLIPOPROTEIN-E GENOTYPE; PLACEBO-CONTROLLED TRIAL; EARLY
   ALZHEIMERS-DISEASE; TRANSGENIC MOUSE MODEL; MINI-MENTAL-STATE;
   QUALITY-OF-LIFE; N-3 FATTY-ACIDS
AB Mild cognitive impairment (MCI) is defined as an intermediate state between normal cognitive aging and dementia. It describes a status of the subjective impression of cognitive decline and objectively detectible memory impairment beyond normal age-related changes. Activities of daily living are not affected. As the population ages, there is a growing need for early, proactive programs that can delay the consequences of dementia and improve the well-being of people with MCI and their caregivers. Various forms and approaches of intervention for older people with MCI have been suggested to delay cognitive decline. Pharmacological as well as non pharmacological approaches (cognitive, physiological, nutritional supplementation, electric stimulation, psychosocial therapeutic) and multicomponent interventions have been proposed. Interventional approaches in MCI from 2009 to April 2019 concerning the cognitive performance are presented in this review.
C1 [Lissek, Vanessa; Suchan, Boris] Ruhr Univ Bochum, Fac Psychol, Neuropsychol Therapy Ctr, Inst Cognit Neurosci Clin Neuropsychol, Univ Str 150, D-44780 Bochum, Germany.
C3 Ruhr University Bochum
RP Lissek, V (corresponding author), Ruhr Univ Bochum, Fac Psychol, Neuropsychol Therapy Ctr, Inst Cognit Neurosci Clin Neuropsychol, Univ Str 150, D-44780 Bochum, Germany.
EM Vanessa.Lissek@ruhr-uni-bochum.de
FU Leitmarkt Agentur.NRW; European Union; state government of North
   Rhine-Westfalia, Germany
FX This work was supported by the Leitmarkt Agentur.NRW, the European Union
   and the state government of North Rhine-Westfalia, Germany. The authors
   would like to thank Dr. Patriza Thoma for very helpful comments on this
   manuscript.
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TC 26
Z9 28
U1 4
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAR
PY 2021
VL 122
BP 143
EP 164
DI 10.1016/j.neubiorev.2020.12.022
EA JAN 2021
PG 22
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA UO7EL
UT WOS:000694856000004
PM 33440197
DA 2023-08-17
ER

PT J
AU Gaitan, A
   Garolera, M
   Cerulla, N
   Chico, G
   Rodriguez-Querol, M
   Canela-Soler, J
AF Gaitan, Adrian
   Garolera, Maite
   Cerulla, Noemi
   Chico, Gloria
   Rodriguez-Querol, Mariona
   Canela-Soler, Jaume
TI Efficacy of an adjunctive computer-based cognitive training program in
   amnestic mild cognitive impairment and Alzheimer's disease: a
   single-blind, randomized clinical trial
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE cognitive training; computer-based cognitive training; dementia; mild
   cognitive impairment
ID DECISION-MAKING; REHABILITATION PROGRAM; OLDER-ADULTS; MEMORY;
   IMPROVEMENT; STIMULATION; ASSOCIATION; PERFORMANCE; DEMENTIA; OUTCOMES
AB Objective This study evaluates the efficacy at 12?months of a computer-based cognitive training (CBCT) program, adjunctive to traditional cognitive training (TCT), on the basis of pen-and-paper exercises.
   Methods Sixty patients with multi-domain mild cognitive impairment and mild Alzheimer's disease who were already receiving cognitive training, recruited from a day hospital, were assigned into two groups following a simple randomization procedure (computerized random numbers): (i) a group that received CBCT during 3?months and TCT (CBCT?+?TCT), n?=?37, and (ii) a group that received only TCT, n?=?23. Patients were assessed at baseline and after 3 and 12?months of treatment by a neuropsychologist blinded to group assignment, with a neuropsychological battery (primary outcomes) and measures of decision making, memory complaints, and emotional disturbances.
   Results With the use of repeated-measures analyses of covariance, the CBCT?+?TCT group showed less anxiety symptoms (F?=?5.13, p?=?0.03, d?=?1.12) and less disadvantageous choices (F?=?4.70, p?=?0.04, d?=?0.89) in decision making than the TCT group at 12?months. No significant improvement or worsening was observed in the other measures examined. However, positive effect sizes favoring the CBCT?+?TCT group were observed in all variables.
   Conclusions The addition of a CBCT program was effective in anxiety and decision making but had no significant effects on outcomes in basic cognitive functions in patients who were already receiving cognitive training, possibly due to a ceiling effect. Future studies should compare the efficacy of CBCT with TCT in naive patients. Copyright (c) 2012 John Wiley & Sons, Ltd.
C1 [Gaitan, Adrian; Garolera, Maite; Cerulla, Noemi; Chico, Gloria] Hosp Terrassa, Neuropsychol Unit, Consorci Sanitari Terrassa, Barcelona, Spain.
   [Gaitan, Adrian; Garolera, Maite] Consorci Sanitari Terrassa, Dept Mental Hlth, Barcelona, Spain.
   [Garolera, Maite] Univ Barcelona, Grp Recerca Consolidat Neuropsicol SGR0941, Barcelona, Spain.
   [Cerulla, Noemi; Chico, Gloria; Rodriguez-Querol, Mariona] St Jordi Day Hosp Cognit Impairment, Consorci Sanitari Terrassa, Barcelona, Spain.
   [Canela-Soler, Jaume] Univ Barcelona, Dept Publ Hlth, Barcelona, Spain.
   [Canela-Soler, Jaume] Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA.
C3 University of Barcelona; University of Barcelona; State University
   System of Florida; University of South Florida
RP Garolera, M (corresponding author), Hosp Terrassa, Neuropsychol Unit, Consorci Sanitari Terrassa, Barcelona, Spain.
EM mgarolera@cst.cat
RI Garolera, Maite/A-3109-2015; Garolera, Maite/D-7811-2012; Cerulla
   Torrente, Noemi/I-7291-2016
OI Garolera, Maite/0000-0001-7443-8249; Garolera,
   Maite/0000-0001-7443-8249; Cerulla Torrente, Noemi/0000-0002-2066-3536
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NR 53
TC 48
Z9 52
U1 2
U2 56
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD JAN
PY 2013
VL 28
IS 1
BP 91
EP 99
DI 10.1002/gps.3794
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 051QB
UT WOS:000312141000011
PM 22473855
DA 2023-08-17
ER

PT J
AU Flak, MM
   Hernes, SS
   Skranes, J
   Lohaugen, GCC
AF Flak, Marianne M.
   Hernes, Susanne S.
   Skranes, Jon
   Lohaugen, Gro C. C.
TI The Memory Aid study: protocol for a randomized controlled clinical
   trial evaluating the effect of computer-based working memory training in
   elderly patients with mild cognitive impairment (MCI)
SO TRIALS
LA English
DT Article
ID FLUID INTELLIGENCE; PROCESSING SPEED; CHILDREN; DOPAMINE; BRAIN;
   INTERVENTIONS; PLASTICITY; DEFICITS; IMPACTS; GAINS
AB Background: Mild cognitive impairment (MCI) is a condition characterized by memory problems that are more severe than the normal cognitive changes due to aging, but less severe than dementia. Reduced working memory (WM) is regarded as one of the core symptoms of an MCI condition. Recent studies have indicated that WM can be improved through computer-based training. The objective of this study is to evaluate if WM training is effective in improving cognitive function in elderly patients with MCI, and if cognitive training induces structural changes in the white and gray matter of the brain, as assessed by structural MRI.
   Methods/Designs: The proposed study is a blinded, randomized, controlled trail that will include 90 elderly patients diagnosed with MCI at a hospital-based memory clinic. The participants will be randomized to either a training program or a placebo version of the program. The intervention is computerized WM training performed for 45 minutes of 25 sessions over 5 weeks. The placebo version is identical in duration but is non-adaptive in the difficulty level of the tasks. Neuropsychological assessment and structural MRI will be performed before and 1 month after training, and at a 5-month folllow-up.
   Discussion: If computer-based training results in positive changes to memory functions in patients with MCI this may represent a new, cost-effective treatment for MCI. Secondly, evaluation of any training-induced structural changes to gray or white matter will improve the current understanding of the mechanisms behind effective cognitive interventions in patients with MCI.
C1 [Flak, Marianne M.; Hernes, Susanne S.] Sorlandet Hosp, Memory Clin, Dept Med, Geriatr Unity, Arendal, Norway.
   [Flak, Marianne M.; Skranes, Jon; Lohaugen, Gro C. C.] Sorlandet Hosp, Dept Pediat, Arendal, Norway.
   [Skranes, Jon; Lohaugen, Gro C. C.] Norwegian Univ Sci & Technol, Dept Lab Med Childrens & Womens Hlth, N-7034 Trondheim, Norway.
C3 Norwegian University of Science & Technology (NTNU)
RP Flak, MM (corresponding author), Sorlandet Hosp, Memory Clin, Dept Med, Geriatr Unity, Arendal, Norway.
EM marianne.moretro.flak@sshf.no
RI Hernes, Susanne/H-7653-2019
OI Hernes, Susanne/0000-0001-6018-652X; Douet, Vanessa/0000-0002-5162-8944
FU South-Eastern Norway Regional Health Authority; Sorlandet Hospital HF
FX We are grateful for the funding from the South-Eastern Norway Regional
   Health Authority and Sorlandet Hospital HF.
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NR 49
TC 28
Z9 29
U1 1
U2 43
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD MAY 3
PY 2014
VL 15
AR 156
DI 10.1186/1745-6215-15-156
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA AG7OK
UT WOS:000335607200001
PM 24886034
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Hyer, L
   Atkinson, M
   Dalibwala, J
   Yeager, C
AF Hyer, L.
   Atkinson, M.
   Dalibwala, J.
   Yeager, C.
TI Cognitive Intervention: Cogmed Applied to Older Adults with Mild
   Cognitive Impairment
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
U1 1
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2011
VL 26
IS 6
BP 507
EP 507
PG 1
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 818XH
UT WOS:000294789500104
DA 2023-08-17
ER

PT J
AU Anderson, MS
   Morris, DL
   McDougall, GJ
   Wykle, M
AF Anderson, M. S.
   Morris, D. L.
   McDougall, G. J.
   Wykle, M.
TI TARGETED INTERVENTIONS IN OLDER ADULTS EXPERIENCING MILD COGNITIVE
   IMPAIRMENT
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Anderson, M. S.] Carilion Clin Ctr Healthy Aging, Roanoke, VA USA.
   [Morris, D. L.; McDougall, G. J.; Wykle, M.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
C3 Case Western Reserve University
NR 0
TC 0
Z9 0
U1 0
U2 2
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 126
EP 126
PG 1
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 519UI
UT WOS:000271793900591
DA 2023-08-17
ER

PT J
AU Li, DN
   Mielke, MM
   Bell, WR
   Reilly, C
   Zhang, L
   Lin, FV
   Yu, F
AF Li, Danni
   Mielke, Michelle M.
   Bell, W. Robert
   Reilly, Cavan
   Zhang, Lin
   Lin, Feng Vankee
   Yu, Fang
TI Blood biomarkers as surrogate endpoints of treatment responses to
   aerobic exercise and cognitive training (ACT) in amnestic mild cognitive
   impairment: the blood biomarkers study protocol of a randomized
   controlled trial (the ACT Trial)
SO TRIALS
LA English
DT Article
DE Aerobic exercise; Alzheimer's disease; Cognitive training; Blood
   biomarkers; Neuropathological biomarkers; Neurodegenerative biomarkers;
   Neurotrophic biomarkers; Surrogate endpoints; Treatment responses and
   amnestic mild cognitive impairment
ID PLASMA NEUROFILAMENT LIGHT; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE;
   MULTIPLEX ASSAY; GROWTH-FACTOR; TOTAL TAU; BRAIN; DECLINE; RISK;
   PERFORMANCE
AB Background Alzheimer's disease (AD) is an epidemic with tremendous public health impacts because there are currently no disease-modifying therapeutics. Randomized controlled trials (RCTs) for prevention of AD dementia often use clinical endpoints that take years to manifest (e.g., cognition) or surrogate endpoints that are costly or invasive (e.g., magnetic resonance imaging [MRI]). Blood biomarkers represent a clinically applicable alternative surrogate endpoint for RCTs that would be both cost-effective and minimally invasive, but little is known about their value as surrogate endpoints for treatment responses in the prevention of AD dementia. Methods The objective of this study is to investigate blood neuropathological, neurodegenerative, and neurotrophic biomarkers as surrogate endpoints for treatment responses to three interventions in older adults with amnestic mild cognitive impairment (aMCI, a prodromal stage of AD): aerobic exercise, cognitive training, and combined aerobic exercise and cognitive training (ACT). We chose these three sets of biomarkers for their unique mechanistic associations with AD pathology, neurodegeneration and neurogenesis. This study is built on the ACT Trial (1R01AG055469), a single-blinded, multi-site, 2 x 2 factorial phase II RCT that examines the synergistic effects of a 6-month ACT intervention on cognition and MRI biomarkers (AD-signature cortical thickness and hippocampal volume) (n = 128). In this ACT Trial blood biomarkers study, we will enroll 120 ACT Trial participants with aMCI and measure blood biomarkers at baseline and at 3, 6, 12, and 18 months. The goals are to (1) determine the effect of interventions on blood biomarkers over 6 months, (2) evaluate blood biomarkers as surrogate endpoints for predicting cognitive responses to interventions over 18 months, and (3, exploratory) examine blood biomarkers as surrogate endpoints for predicting brain MRI biomarker responses to interventions over 18 months. Discussion This study aims to identify new blood biomarkers that can track cognitive decline or AD-related brain atrophy among patients with aMCI subjected to a regimen of aerobic exercise and cognitive training. Findings from this study will drive the further use of blood biomarkers in developing effective prevention and treatment strategies for AD dementia.
C1 [Li, Danni; Bell, W. Robert] Univ Minnesota, Dept Lab Med & Pathol, 420 Delaware St SE,MMC 609, Minneapolis, MN 55455 USA.
   [Mielke, Michelle M.] Mayo Clin, Dept Neurol & Hlth Sci Res, Coll Med, Rochester, MN 55902 USA.
   [Reilly, Cavan; Zhang, Lin] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA.
   [Lin, Feng Vankee] Univ Rochester, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA.
   [Yu, Fang] Univ Minnesota, Sch Nursing, 5-140 WDH,308 Harvard St SE, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Mayo Clinic; University of Minnesota System; University of Minnesota
   Twin Cities; University of Rochester; University of Minnesota System;
   University of Minnesota Twin Cities
RP Li, DN (corresponding author), Univ Minnesota, Dept Lab Med & Pathol, 420 Delaware St SE,MMC 609, Minneapolis, MN 55455 USA.; Yu, F (corresponding author), Univ Minnesota, Sch Nursing, 5-140 WDH,308 Harvard St SE, Minneapolis, MN 55455 USA.
EM dannili@umn.edu; yuxxx244@umn.edu
OI Yu, Fang/0000-0002-9399-1987; Li, Danni/0000-0002-0608-2831; Lin, Feng
   Vankee/0000-0003-1945-0362
FU NIH's National Institute on Aging [R01AG05965401, 8/1/2018-5/31/2022]
FX This study is funded by the NIH's National Institute on Aging
   (R01AG05965401, 8/1/2018-5/31/2022).
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NR 43
TC 2
Z9 2
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JAN 6
PY 2020
VL 21
IS 1
AR 19
DI 10.1186/s13063-019-3798-1
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KN2BY
UT WOS:000514647500020
PM 31907024
OA Green Published, gold, Green Submitted
DA 2023-08-17
ER

PT J
AU Kalbe, E
   Folkerts, AK
   Ophey, A
   Eggers, C
   Elben, S
   Dimenshteyn, K
   Sulzer, P
   Schulte, C
   Schmidt, N
   Schlenstedt, C
   Berg, D
   Witt, K
   Wojtecki, L
   Liepelt-Scarfone, I
AF Kalbe, Elke
   Folkerts, Ann-Kristin
   Ophey, Anja
   Eggers, Carsten
   Elben, Saskia
   Dimenshteyn, Karina
   Sulzer, Patricia
   Schulte, Claudia
   Schmidt, Nele
   Schlenstedt, Christian
   Berg, Daniela
   Witt, Karsten
   Wojtecki, Lars
   Liepelt-Scarfone, Inga
TI Enhancement of Executive Functions but Not Memory by Multidomain Group
   Cognitive Training in Patients with Parkinson's Disease and Mild
   Cognitive Impairment: A Multicenter Randomized Controlled Trial
SO PARKINSONS DISEASE
LA English
DT Article
ID QUALITY-OF-LIFE; VERBAL FLUENCY; EFFICACY; INTERVENTIONS; METAANALYSIS;
   IMPACT; MCI
AB Background. Meta-analyses have demonstrated cognitive training (CT) benefits in Parkinson's disease (PD) patients. However, the patients' cognitive status has only rarely been based on established criteria. Also, prediction analyses of CT success have only sparsely been conducted. Objective. To determine CT effects in PD patients with mild cognitive impairment (PD-MCI) on cognitive and noncognitive outcomes compared to an active control group (CG) and to analyze CT success predictors. Methods. Sixty-four PD-MCI patients (age: 67.61 +/- 7.70; UPDRS-III: 26.58 +/- 13.54; MoCA: 24.47 +/- 2.78) were randomized to either a CT group or a low-intensity physical activity CG for six weeks (twice weekly, 90 minutes). Outcomes were assessed before and after training. MANOVAs with follow-up ANOVAs and multiple regression analyses were computed. Results. Both interventions were highly feasible (participation, motivation, and evaluation); the overall dropout rate was 4.7%. Time x group interaction effects favoring CT were observed for phonemic fluency as a specific executive test (p=0.018, eta(2)(p)=0.092) and a statistical trend for overall executive functions (p=0.095, eta(2)(p)=0.132). A statistical trend for a time x group interaction effect favoring CG was shown for the digit span backward as a working memory test (p=0.098, eta(2)(p)=0.043). Regression analyses revealed cognitive baseline levels, education, levodopa equivalent daily dose, motor scores, and ApoE status as significant predictors for CT success. Conclusions. CT is a safe and feasible therapy option in PD-MCI, yielding executive functions improvement. Data indicate that vulnerable individuals may show the largest cognitive gains. Longitudinal studies are required to determine whether CT may also attenuate cognitive decline in the long term. This trial is registered with DRKS00010186.
C1 [Kalbe, Elke; Folkerts, Ann-Kristin; Ophey, Anja] Univ Cologne, Med Psychol Neuropsychol & Gender Studies, Cologne, Germany.
   [Kalbe, Elke; Folkerts, Ann-Kristin; Ophey, Anja] Univ Cologne, Ctr Neuropsychol Diagnost & Intervent CeNDI, Fac Med, Cologne, Germany.
   [Kalbe, Elke; Folkerts, Ann-Kristin; Ophey, Anja; Eggers, Carsten] Univ Cologne, Univ Hosp Cologne, Cologne, Germany.
   [Eggers, Carsten] Univ Marburg & Giessen, Ctr Mind Brain & Behav CMBB, Univ Hosp Marburg, Dept Neurol, Marburg, Germany.
   [Eggers, Carsten] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany.
   [Elben, Saskia; Dimenshteyn, Karina] Heinrich Heine Univ Duesseldorf, Med Fac, Ctr Movement Disorders & Neuromodulat, Dept Neurol, Dusseldorf, Germany.
   [Elben, Saskia; Dimenshteyn, Karina] Heinrich Heine Univ Duesseldorf, Med Fac, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany.
   [Sulzer, Patricia; Schulte, Claudia; Liepelt-Scarfone, Inga] Univ Tubingen, German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany.
   [Sulzer, Patricia; Schulte, Claudia; Liepelt-Scarfone, Inga] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany.
   [Schmidt, Nele; Schlenstedt, Christian; Berg, Daniela; Witt, Karsten] Univ Kiel, Univ Hosp Schleswig Holstein, Dept Neurol, Kiel, Germany.
   [Witt, Karsten] Carl von Ossietzky Univ Oldenburg, Res Ctr Neurosensory Sci, Oldenburg, Germany.
   [Wojtecki, Lars] Hosp Zum Heiligen Geist, Dept Neurol, Frankfurt, Germany.
C3 University of Cologne; University of Cologne; University of Cologne;
   University Hospital of Giessen & Marburg; University of Cologne;
   Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE); Eberhard Karls University of
   Tubingen; Eberhard Karls University Hospital; Helmholtz Association;
   German Center for Neurodegenerative Diseases (DZNE); University of Kiel;
   Schleswig Holstein University Hospital; Carl von Ossietzky Universitat
   Oldenburg
RP Kalbe, E (corresponding author), Univ Cologne, Med Psychol Neuropsychol & Gender Studies, Cologne, Germany.; Kalbe, E (corresponding author), Univ Cologne, Ctr Neuropsychol Diagnost & Intervent CeNDI, Fac Med, Cologne, Germany.
EM elke.kalbe@uk-koeln.de; ann-kristin.folkerts@uk-koeln.de;
   anja.ophey@uk-koeln.de; carsten.eggers@uk-gm.de;
   saskia.elben@med.uni-duesseldorf.de;
   karina.dimenshteyn@med.uni-duesseldorf.de;
   patricia.sulzer@med.uni-tuebingen.de; claudia.schulte@uni-tuebingen.de;
   n.schmidt@neurologie.uni-kiel.de; c.schlenstedt@neurologie.uni-kiel.de;
   daniela.berg@uksh.de; karsten.witt@uni-oldenburg.de;
   lars.wojtecki@med.uni-duesseldorf.de; inga.liepelt@uni-tuebingen.de
RI Wojtecki, Lars/AAT-6604-2021; Berg, Daniela/A-8728-2019; Ophey,
   Anja/ABE-2010-2021; Ophey, Anja/HTQ-7893-2023
OI Wojtecki, Lars/0000-0002-6205-4405; Berg, Daniela/0000-0001-5796-5442;
   Ophey, Anja/0000-0001-5858-7762; Schlenstedt,
   Christian/0000-0002-3838-6848; Folkerts, Ann-Kristin/0000-0003-2168-140X
FU ParkinsonFonds Germany GmbH
FX The authors thank the German Parkinson's Disease Association (dPV) for
   supporting the recruitment of the patients as well as the German Center
   for Neurodegenerative Diseases (DZNE), especially Silke Greuel, for
   helping with data management. Besides, the authors give their thanks to
   the physiotherapists and move gerontologists who conducted the physical
   activity program and Sara Becker, Richard Dano, Sarah Dolker, Andrea
   Greuel, Luise Liebig, Juliane Spath, Paula Trauberg, and Carlos Trenado
   for supporting the data acquisition. This work was financially supported
   by the ParkinsonFonds Germany GmbH.
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NR 62
TC 7
Z9 8
U1 1
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-8083
EI 2042-0080
J9 PARKINSONS DIS-US
JI Parkinsons Dis.
PD NOV 30
PY 2020
VL 2020
AR 4068706
DI 10.1155/2020/4068706
PG 15
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA PG7OR
UT WOS:000599921000001
PM 33312495
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Kinsella, GJ
   Mullaly, E
   Rand, E
   Ong, B
   Burton, C
   Price, S
   Phillips, M
   Storey, E
AF Kinsella, G. J.
   Mullaly, E.
   Rand, E.
   Ong, B.
   Burton, C.
   Price, S.
   Phillips, M.
   Storey, E.
TI Early intervention for mild cognitive impairment: a randomised
   controlled trial
SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
LA English
DT Article
ID ALZHEIMERS-DISEASE; PROSPECTIVE MEMORY; RESEARCH CRITERIA; WORKING
   GROUP; OLDER-ADULTS; REHABILITATION; MCI; RETRIEVAL; DIAGNOSIS; DEMENTIA
AB Background: Positive effects are reported for memory training for healthy older adults, and yet there is limited information about the benefit of cognitive intervention for older adults with increasing memory difficulties-mild cognitive impairment.
   Objective: To investigate the usefulness of an early cognitive intervention for the memory difficulties experienced by people with amnestic mild cognitive impairment.
   Methods: Using a randomised control design, 52 participants with amnestic mild cognitive impairment and their family partners were randomly assigned to a cognitive intervention (memory rehabilitation group) or waitlist (control group). Participants were assessed on primary measures of everyday memory (prospective memory) and memory strategies at 2 weeks' and 4 months' follow-up; secondary measures of contentment with memory and the family participants' knowledge of memory strategies were also assessed.
   Results: Everyday memory, measured by performance on prospective memory tasks, significantly improved following intervention, although self-appraisal of everyday memory did not demonstrate a similar intervention effect. Knowledge and use of memory strategies also significantly increased following intervention. Furthermore, family knowledge of memory strategies increased following intervention. There was a strong trend towards improvement in contentment with memory immediately following intervention, but this effect was not significant.
   Conclusions: Early intervention for memory difficulties in amnestic mild cognitive impairment, using cognitive rehabilitation in compensatory strategies, can assist in minimising everyday memory failures as evaluated by performance on prospective memory tasks and knowledge of memory strategies.
C1 [Kinsella, G. J.; Ong, B.; Burton, C.; Price, S.] La Trobe Univ, Melbourne, Vic 3086, Australia.
   [Kinsella, G. J.; Mullaly, E.] Caulfield Hosp, Psychol Serv, Melbourne, Vic, Australia.
   [Mullaly, E.; Rand, E.; Storey, E.] Caulfield Hosp, Cognit Dementia & Memory Serv, Melbourne, Vic, Australia.
   [Phillips, M.] Bundoora Extended Care Ctr, Cognit Dementia & Memory Serv, Melbourne, Vic, Australia.
   [Storey, E.] Monash Univ, Dept Med Neurosci, Melbourne, Vic 3004, Australia.
C3 La Trobe University; Monash University
RP Kinsella, GJ (corresponding author), La Trobe Univ, Melbourne, Vic 3086, Australia.
EM g.kinsella@latrobe.edu.au
RI Storey, Elsdon/A-9889-2013; Kinsella, Glynda/O-6347-2017
OI Kinsella, Glynda/0000-0002-5859-0934
FU Alzheimer's Australia Research; Caulfield Hospital; La Trobe University
FX The research was supported by grants from Alzheimer's Australia
   Research, Caulfield Hospital and La Trobe University.
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NR 47
TC 157
Z9 162
U1 1
U2 55
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-3050
EI 1468-330X
J9 J NEUROL NEUROSUR PS
JI J. Neurol. Neurosurg. Psychiatry
PD JUL
PY 2009
VL 80
IS 7
BP 730
EP 736
DI 10.1136/jnnp.2008.148346
PG 7
WC Clinical Neurology; Psychiatry; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry; Surgery
GA 458TQ
UT WOS:000267046800007
PM 19332424
DA 2023-08-17
ER

PT J
AU Buschert, VC
   Friese, U
   Teipel, SJ
   Schneider, P
   Merensky, W
   Rujescu, D
   Moller, HJ
   Hampel, H
   Buerger, K
AF Buschert, Verena C.
   Friese, Uwe
   Teipel, Stefan J.
   Schneider, Philine
   Merensky, Wibke
   Rujescu, Dan
   Moeller, Hans-Juergen
   Hampel, Harald
   Buerger, Katharina
TI Effects of a Newly Developed Cognitive Intervention in Amnestic Mild
   Cognitive Impairment and Mild Alzheimer's Disease: A Pilot Study
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Alzheimer's disease; cognitive intervention; cognitive stimulation;
   cognitive training; mild cognitive impairment; stage-specific
ID FACE-NAME ASSOCIATIONS; QUALITY-OF-LIFE; STIMULATION THERAPY;
   CHOLINERGIC DRUGS; BRAIN RESERVE; OLDER-ADULTS; REHABILITATION;
   DEMENTIA; MEMORY; DEPRESSION
AB Recent studies have shown that patients with Alzheimer's disease (AD) and its possible prodromal stage mild cognitive impairment (MCI) benefit from cognitive interventions. Few studies so far have used an active control condition and determined effects in different stages of disease. We evaluated a newly developed 6-month group-based multicomponent cognitive intervention in a randomized controlled pilot study on subjects with amnestic mild cognitive impairment (aMCI) and mild AD patients. Forty-three subjects with aMCI and mild AD were recruited. Primary outcome measures were change in global cognitive function as determined by the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and the Mini Mental Status Examination (MMSE). Secondary outcomes were specific cognitive and psychopathological ratings. Thirty-nine patients were randomized to intervention groups (IGs: 12 aMCI, 8 AD) and active control groups (CGs: 12 aMCI, 7 AD). At the end of the study, we found significant improvements in the IG(MCI) compared to the CG(MCI) in the ADAS-cog (p = 0.02) and for the secondary endpoint Montgomery Asberg Depression Rating Scale (MADRS) (p < 0.01) Effects on the MMSE score showed a non-significant trend (p = 0.07). In AD patients, we found no significant effect of intervention on the primary outcome measures. In conclusion, these results suggest that participation in a 6-month cognitive intervention can improve cognitive and non-cognitive functions in aMCI subjects. In contrast, AD patients showed no significant benefit from intervention. The findings in this small sample support the use of the intervention in larger scales studies with extended follow-up period to determine long-term effects.
C1 [Buschert, Verena C.] Univ Munich, Dept Psychiat, Alzheimer Mem Ctr, Dementia Res Sect, D-80336 Munich, Germany.
   Univ Rostock, Dept Psychiat, Rostock, Germany.
   [Friese, Uwe] Univ Osnabrueck, Inst Psychol, Osnabruck, Germany.
   [Teipel, Stefan J.] German Ctr Neurodegenerat Disorders, DZNE, Rostock, Germany.
   [Hampel, Harald] Goethe Univ Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany.
   [Buerger, Katharina] Univ Munich, Klinikum Grosshadern, Inst Stroke & Dementia Res, Munich, Germany.
C3 University of Munich; University of Rostock; University Osnabruck;
   Helmholtz Association; German Center for Neurodegenerative Diseases
   (DZNE); Goethe University Frankfurt; University of Munich
RP Buschert, VC (corresponding author), Univ Munich, Dept Psychiat, Alzheimer Mem Ctr, Dementia Res Sect, Nussbaumstr 7, D-80336 Munich, Germany.
EM verena.buschert@med.uni-muenchen.de
RI Lista, Simone/AAC-6473-2021; Rujescu, Dan/GRS-3875-2022
OI Lista, Simone/0000-0001-6804-7858; Hampel, Harald/0000-0003-0894-8982
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NR 76
TC 101
Z9 108
U1 1
U2 33
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2011
VL 25
IS 4
BP 679
EP 694
DI 10.3233/JAD-2011-100999
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 803QI
UT WOS:000293595400010
PM 21483095
DA 2023-08-17
ER

PT J
AU Liao, YY
   Chen, IH
   Lin, YJ
   Chen, Y
   Hsu, WC
AF Liao, Ying-Yi
   Chen, I-Hsuan
   Lin, Yi-Jia
   Chen, Yue
   Hsu, Wei-Chun
TI Effects of Virtual Reality-Based Physical and Cognitive Training on
   Executive Function and Dual-Task Gait Performance in Older Adults With
   Mild Cognitive Impairment: A Randomized Control Trial
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE dual-task gait; MCI; virtual reality; executive function; combined
   physical and cognitive training
ID MULTICOMPONENT EXERCISE; WALKING; ATTENTION; RISK; DEMENTIA; DEFICITS;
   DECLINE; DISEASE; PROFILE; VERSION
AB Background: Walking while performing cognitive and motor tasks simultaneously interferes with gait performance and may lead to falls in older adults with mild cognitive impairment (MCI). Executive function, which seems to play a key role in dual-task gait performance, can be improved by combined physical and cognitive training. Virtual reality (VR) has the potential to assist rehabilitation, and its effect on physical and cognitive function requires further investigation. The purpose of this study was to assess the effects of VR-based physical and cognitive training on executive function and dual-task gait performance in older adults with MCI, as well as to compare VR-based physical and cognitive training with traditional combined physical and cognitive training.
   Method: Thirty-four community-dwelling older adults with MCI were randomly assigned into either a VR-based physical and cognitive training (VR) group or a combined traditional physical and cognitive training (CPC) group for 36 sessions over 12 weeks. Outcome measures included executive function [Stroop Color and Word Test (SCWT) and trail making test (TMT) A and B], gait performance (gait speed, stride length, and cadence) and dual-task costs (DTCs). Walking tasks were performed during single-task walking, walking while performing serial subtraction (cognitive dual task), and walking while carrying a tray (motor dual task). The GAIT Up system was used to evaluate gait parameters including speed, stride length, cadence and DTCs. DTC were defined as 100 * (single-task gait parameters dual-task gait parameters)/single-task gait parameters.
   Results: Both groups showed significant improvements in the SCWT and single-task and motor dual-task gait performance measures. However, only the VR group showed improvements in cognitive dual-task gait performance and the DTC of cadence. Moreover, the VR group showed more improvements than the CPC group in the TMT-B and DTC of cadence with borderline significances.
   Conclusion: A 12-week VR-based physical and cognitive training program led to significant improvements in dual-task gait performance in older adults with MCI, which may be attributed to improvements in executive function.
C1 [Liao, Ying-Yi] Natl Taipei Univ Nursing & Hlth Sci, Dept Gerontol Hlth Care, Taipei, Taiwan.
   [Chen, I-Hsuan] Fooyin Univ, Dept Phys Therapy, Kaohsiung, Taiwan.
   [Lin, Yi-Jia; Chen, Yue; Hsu, Wei-Chun] Natl Taiwan Univ Sci & Technol, Grad Inst Biomed Engn, Taipei, Taiwan.
C3 National Taipei University of Nursing & Health Science (NTUNHS); Fooyin
   University; National Taiwan University of Science & Technology
RP Hsu, WC (corresponding author), Natl Taiwan Univ Sci & Technol, Grad Inst Biomed Engn, Taipei, Taiwan.
EM wchsu@mail.ntust.edu.tw
FU Ministry of Science and Technology [MOST 106-2314-B-227-008, MOST
   108-2622-H-011-001-CC3, MOST 104-2628-E-011-006-MY3]
FX This work was supported by grants from the Ministry of Science and
   Technology (MOST 106-2314-B-227-008, MOST 108-2622-H-011-001-CC3 and
   MOST 104-2628-E-011-006-MY3).
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NR 52
TC 79
Z9 87
U1 14
U2 70
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JUL 16
PY 2019
VL 11
AR 162
DI 10.3389/fnagi.2019.00162
PG 10
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA IJ4XB
UT WOS:000475906200001
PM 31379553
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Kinsella, G
   Ong, B
   Mullaly, E
   Rand, E
   Storey, E
AF Kinsella, G.
   Ong, B.
   Mullaly, E.
   Rand, E.
   Storey, E.
TI PROSPECTIVE MEMORY AS AN OUTCOME MEASURE OF COGNITIVE INTERVENTION FOR
   MILD COGNITIVE IMPAIRMENT
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Kinsella, G.; Ong, B.] La Trobe Univ, Melbourne, Vic, Australia.
   [Mullaly, E.; Rand, E.] Caulfield Gen Med Ctr, Melbourne, Vic, Australia.
   [Storey, E.] Monash Univ, Melbourne, Vic 3004, Australia.
C3 La Trobe University; Monash University
RI Kinsella, Glynda/O-6347-2017
OI Kinsella, Glynda/0000-0002-5859-0934
NR 0
TC 0
Z9 0
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
EI 1758-5341
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2008
VL 48
SI 3
BP 503
EP 503
PG 1
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 399PA
UT WOS:000262810602010
DA 2023-08-17
ER

PT J
AU Granland, KA
   Thompson, CL
   Dong, YH
AF Granland, Kim A.
   Thompson, Claire L.
   Dong, Yanhong
TI "Train Your Brain" Cognitive Intervention Group Program for Singaporean
   Older Adult Patients With Mild Cognitive Impairment: A Pilot Feasibility
   Study
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Article
DE cognitive intervention; cognitive training; older adults; mild cognitive
   impairment
ID MENTAL-DISORDERS; POPULATION; RESERVE; RISK
AB The "Train Your Brain" (TYB) cognitive intervention group program was developed based on previous research with the goal of remediating cognitive impairments for elderly Singaporean people with mild cognitive impairment (MCI). This study reports a pilot evaluation of feasibility (defined as participant attendance, retention rate, satisfaction and usefulness) and preliminary efficacy of the TYB program. Nineteen participants with MCI aged >= 50 years were recruited from a memory clinic in Singapore, with 14 receiving the TYB intervention. Participants were allocated in order of recruitment into consecutive identical groups for a 9-session program on brain health and cognitive training. Participants received pre- and post-intervention measures of cognition and completed feedback forms reporting on satisfaction with, and utility of, the TYB program. TYB was well attended (85% attendance for the first 6 sessions; 83% for the full 9-session TYB program). Participant satisfaction was high, with positive participant feedback reporting that TYB offered useful cognitive strategies which participants could implement in their daily life. Despite the small sample size and absence of control group, repeated-measures t-tests revealed significant pre- to post-intervention intra-individual improvement in global cognition measured by the Montreal Cognitive Assessment, and in executive function on the Brixton Spatial Anticipation Test. This pilot study provides supportive preliminary evidence for feasibility of TYB, with suggestions of efficacy of this program as a culturally and linguistically appropriate intervention for English-speaking older adults with MCI in Singapore.
C1 [Granland, Kim A.] James Cook Univ, Dept Psychol, Singapore, Singapore.
   [Thompson, Claire L.] Cent Queensland Univ, Coll Psychol, Rockhampton, Qld, Australia.
   [Dong, Yanhong] Natl Univ Singapore, Yong Loo Lin Sch Med, Alice Lee Ctr Nursing Studies, Singapore, Singapore.
C3 James Cook University; Central Queensland University; National
   University of Singapore
RP Dong, YH (corresponding author), Yong Loo Lin Sch Med, Alice Lee Ctr Nursing Studies, Clin Res Ctr, Level 2,MD11,10 Med Dr, Singapore 117597, Singapore.
EM nurdy@nus.edu.sg
RI Thompson, Claire/AAR-3726-2021; Thompson, Claire/H-5181-2011
OI Thompson, Claire/0000-0001-9538-3371
FU Singapore National University Health System Clinician Scientist Program
   Award; Singapore National Medical Research Council (NMRC) Transition
   Award [NMRC/TA/0060/2017]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Yanhong
   Dong was a recipient of Singapore National University Health System
   Clinician Scientist Program Award and Singapore National Medical
   Research Council (NMRC) Transition Award [NMRC/TA/0060/2017] during this
   study.
CR [Anonymous], 1997, HAYLING BRIXTON TEST
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NR 28
TC 0
Z9 0
U1 4
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
EI 1552-5708
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD MAY
PY 2022
VL 35
IS 3
BP 442
EP 449
AR 08919887211002661
DI 10.1177/08919887211002661
EA MAR 2021
PG 8
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA 0I8MY
UT WOS:000630568600001
PM 33733903
DA 2023-08-17
ER

PT J
AU Gomez-Soria, I
   Peralta-Marrupe, P
   Calatayud-Sanz, E
   Latorre, E
AF Gomez-Soria, I
   Peralta-Marrupe, P.
   Calatayud-Sanz, E.
   Latorre, E.
TI Efficacy of cognitive intervention programs in amnesic mild cognitive
   impairment: A systematic review
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Review
DE Cognition; Cognitive training; Cognitive rehabilitation; Cognitive
   stimulation; Mini-mental state examination
ID RANDOMIZED CONTROLLED-TRIAL; ALZHEIMERS-DISEASE; WORKING-MEMORY;
   REHABILITATION PROGRAM; BRAIN METABOLISM; OLDER-ADULTS; MCI; PEOPLE;
   STIMULATION; OUTCOMES
AB Background: : Amnesic mild cognitive impairment (aMCI) is considered a prodromal stage of Alzheimer's disease. Given the absence of an effective pharmacological treatment for aMCI, increasing numbers of studies are attempting to understand how cognitive interventions could benefit aMCI patients. The aim of this systematic review was to evaluate the current evidence regarding the efficacy on cognition of cognitive intervention programs in older adults with aMCI. Methods: : We searched for randomized controlled trials and clinical trials published until March 2020 on PubMed, Web of Science, Cochrane Library, SCOPUS, and OTseeker. A total of 454 works were identified and 7 studies that met the inclusion criteria, were included in this review. PRISMA guidelines were followed and PEDro scale was included for the measurement of the quality of the selected studies. Results: : Cognitive interventions showed positive effects on cognition. Cognitive training programs considerably enhanced the Mini Mental State Examination scores. However, no relevant differences in global cognition were found using other assessment tools as DRS-2 or ADAS-Cog Scale. Cognitive training and cognitive rehabilitation programs seemed to improve several cognitive domains as memory, language or executive function in aMCI patients in both post-training and at follow-up analysis. Conclusions: : Our findings support that cognitive interventions can be an effective option for people with aMCI. Cognitive interventions improved global cognitive function post-intervention, but also seemed to enhance some cognitive domains post-intervention and at follow-up. However, more studies are needed to analyze the potential benefits of cognitive intervention on aMCI.
C1 [Gomez-Soria, I; Calatayud-Sanz, E.] Univ Zaragoza, Fac Hlth Sci, Dept Physiatry & Nursery, Zaragoza, Spain.
   [Peralta-Marrupe, P.] Reyes de Aragon Orpea Care Home, San Juan de la Cruz 22, Zaragoza 50006, Spain.
   [Latorre, E.] Univ Zaragoza, Dept Biochem & Cell Biol, Fac Sci, Zaragoza, Spain.
   [Latorre, E.] Inst Hlth Res Aragon IIS Aragon, Zaragoza, Spain.
C3 University of Zaragoza; University of Zaragoza
RP Peralta-Marrupe, P (corresponding author), Reyes de Aragon Orpea Care Home, San Juan de la Cruz 22, Zaragoza 50006, Spain.
EM peraltamarrupe@hotmail.com
RI SANZ, ESTELA CALATAYUD/AFC-4477-2022; Gómez-Soria, Isabel/HOH-7752-2023;
   Gómez-Soria, Isabel/ITU-7980-2023
OI Gómez-Soria, Isabel/0000-0002-0061-3312; Gómez-Soria,
   Isabel/0000-0002-0061-3312; , Patricia/0000-0002-7210-5704; Calatayud
   Sanz, Estela/0000-0002-4307-796X
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NR 53
TC 3
Z9 5
U1 4
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD MAY-JUN
PY 2021
VL 94
AR 104332
DI 10.1016/j.archger.2020.104332
EA JAN 2021
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA UU3CL
UT WOS:000698677200007
PM 33486120
DA 2023-08-17
ER

PT J
AU Booth, V
   Harwood, RH
   Hood-Moore, V
   Bramley, T
   Hancox, JE
   Robertson, K
   Hall, J
   Van der Wardt, V
   Logan, PA
AF Booth, Vicky
   Harwood, Rowan H.
   Hood-Moore, Victoria
   Bramley, Trevor
   Hancox, Jennie E.
   Robertson, Kate
   Hall, Judith
   Van der Wardt, Veronika
   Logan, Pip A.
TI Promoting activity, independence and stability in early dementia and
   mild cognitive impairment (PrAISED): development of an intervention for
   people with mild cognitive impairment and dementia
SO CLINICAL REHABILITATION
LA English
DT Article
DE Dementia; falls; rehabilitation interventions; activities of daily
   living; physical activity
ID EXERCISE PROGRAM; OLDER-ADULTS; ALZHEIMERS-DISEASE; FALLS PREVENTION;
   RISK; BALANCE; GAIT
AB Introduction: Older adults with dementia are at a high risk of falls. Standard interventions have not been shown to be effective in this patient population potentially due to poor consideration of dementia-specific risk factors. An intervention is required that addresses the particular needs of older people with dementia in a community setting.
   Methods: We followed guidelines for the development of an intervention, which recommend a structured approach considering theory, evidence and practical issues. The process used 15 information sources. Data from literature reviews, clinician workshops, expert opinion meetings, patient-relative interviews, focus groups with people with dementia and clinicians, a cross-sectional survey of risk factors, a pre-post intervention study and case studies were included. Data were synthesized using triangulation to produce an intervention suitable for feasibility testing. Practical consideration of how an intervention could be delivered and implemented were considered from the outset.
   Results: Elements of the intervention included individually tailored, dementia-appropriate, balance, strength and dual-task exercises, functional training, and activities aimed at improving environmental access, delivered using a motivational approach to support adherence and long-term continuation of activity. We focussed on promoting safe activity rather than risk or prevention of falls.
   Conclusion: We used a systematic process to develop a dementia-specific intervention to promote activity and independence while reducing falls risk in older adults with mild dementia.
C1 [Booth, Vicky; Hood-Moore, Victoria; Bramley, Trevor; Hancox, Jennie E.; Robertson, Kate; Van der Wardt, Veronika; Logan, Pip A.] Univ Nottingham, Nottingham NG7 2UH, England.
   [Booth, Vicky; Harwood, Rowan H.; Hall, Judith] Nottingham Univ Hosp NHS Trust, Nottingham, England.
   [Bramley, Trevor] Nottinghamshire Healthcare NHS Fdn Trust, Nottingham, England.
C3 University of Nottingham; Nottingham University Hospital NHS Trust
RP Booth, V (corresponding author), Univ Nottingham, Nottingham NG7 2UH, England.
EM Victoria.Booth@nottingham.ac.uk
RI van der Wardt, Veronika/ABF-3836-2021; Hancox, Jennie/T-6596-2019;
   Hancox, Jennie/F-4551-2015
OI van der Wardt, Veronika/0000-0003-3995-7056; Harwood,
   Rowan/0000-0002-4920-6718; Hancox, Jennie/0000-0001-5938-5265; Booth,
   Vicky/0000-0002-5338-0196; Logan, Philippa/0000-0002-6657-2381
FU United Kingdom National Institute for Health Research under its
   Programme Development Grants for Applied Research funding scheme
   [RP-DG-0611-10013]; Nottingham University Hospitals NHS Trust Charity
   under its Intervention Development Support scheme; Nottingham University
   Hospitals NHS Trust Research and Innovation directorate Research
   Capability Funding; Alzheimer's Society, UK; Healthcare Management Trust
   through a Clinical Training Fellowship [206]; National Institute for
   Health Research [RP-PG-0614-20007] Funding Source: researchfish;
   National Institutes of Health Research (NIHR) [RP-PG-0614-20007,
   RP-DG-0611-10013] Funding Source: National Institutes of Health Research
   (NIHR)
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship and/or publication of this article: This paper
   presents independent research funded by the United Kingdom National
   Institute for Health Research under its Programme Development Grants for
   Applied Research funding scheme (RP-DG-0611-10013); Nottingham
   University Hospitals NHS Trust Charity under its Intervention
   Development Support scheme; Nottingham University Hospitals NHS Trust
   Research and Innovation directorate Research Capability Funding; and
   Alzheimer's Society, UK, with the Healthcare Management Trust through a
   Clinical Training Fellowship (grant number 206) for lead author V.B. The
   views expressed are those of the authors and not necessarily those of
   the National Health Service, the NIHR or the Department of Health.
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   Suttanon P, 2012, INT PSYCHOGERIATR, V24, P1172, DOI 10.1017/S1041610211002729
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   Tian Y, 2013, EXPLORING SYSTEM WID
   Tiedemann A, 2011, J SCI MED SPORT, V14, P489, DOI 10.1016/j.jsams.2011.04.001
   Trombetti A, 2011, ARCH INTERN MED, V171, P525, DOI 10.1001/archinternmed.2010.446
   Van Der Wardt V, 2014, EUR GERIATR MED S1, V5, pS238
   van der Wardt V, 2015, DEMENT GERIATR COGN, V40, P178, DOI 10.1159/000433523
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NR 57
TC 12
Z9 13
U1 0
U2 22
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-2155
EI 1477-0873
J9 CLIN REHABIL
JI Clin. Rehabil.
PD JUL
PY 2018
VL 32
IS 7
BP 855
EP 864
DI 10.1177/0269215518758149
PG 10
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA GM9IR
UT WOS:000438561100002
PM 29436253
OA Green Published, Green Accepted, hybrid
DA 2023-08-17
ER

PT J
AU O'Sullivan, M
   Coen, R
   Hora, DO
   Shiel, A
AF O'Sullivan, M.
   Coen, R.
   Hora, D. O'
   Shiel, A.
TI Cognitive rehabilitation for mild cognitive impairment: developing and
   piloting an intervention
SO AUSTRALASIAN JOURNAL ON AGEING
LA English
DT Meeting Abstract
C1 [O'Sullivan, M.] Hlth Serv, Cork, Ireland.
   [Coen, R.] St James Hosp, Mercers Inst Res Ageing, Memory Clin, Dublin, Ireland.
   [Hora, D. O'] NUIG, Dept Psychol, Galway, Ireland.
   [Shiel, A.] NUIG, Dept Occupat Therapy, Galway, Ireland.
C3 CHARMEU; Trinity College Dublin; Ollscoil na Gaillimhe-University of
   Galway; Ollscoil na Gaillimhe-University of Galway
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-6381
J9 AUSTRALAS J AGEING
JI Australas. Ageing
PD DEC
PY 2012
VL 31
SU 2
SI SI
BP 42
EP 42
PG 1
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 035TT
UT WOS:000310972700105
DA 2023-08-17
ER

PT J
AU Tompkins, C
   Ihara, E
   Liebreich, R
   Fredericksen, J
   Bradley, L
AF Tompkins, Catherine
   Ihara, Emily
   Liebreich, Rob
   Fredericksen, Jessica
   Bradley, Lauren
TI THE STRONGERMEMORY PROGRAM: A BRAIN HEALTH INTERVENTION FOR MILD
   COGNITIVE IMPAIRMENT
SO INNOVATION IN AGING
LA English
DT Meeting Abstract
C1 [Tompkins, Catherine; Ihara, Emily] George Mason Univ, Fairfax, VA 22030 USA.
   [Liebreich, Rob; Fredericksen, Jessica; Bradley, Lauren] Goodwin House, Falls Church, VA USA.
C3 George Mason University
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2399-5300
J9 INNOV AGING
JI Innov. Aging
PY 2021
VL 5
SU 1
BP 143
EP 143
PG 1
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 3V9XA
UT WOS:000842009900554
DA 2023-08-17
ER

PT J
AU Zhao, X
   Wang, LN
   Ge, CX
   Liu, XS
   Chen, M
   Zhang, C
AF Zhao, Xia
   Wang, Lina
   Ge, Chenxi
   Liu, Xiaoshen
   Chen, Mei
   Zhang, Chen
TI Effect of Process-Based Multi-Task Cognitive Training Program on
   Executive Function in Older Adults With Mild Cognitive Impairment: Study
   Rationale and Protocol Design for a Randomized Controlled Trial
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE mild cognitive impairment; process-based training; executive function;
   cognitive assessment; transfer effects
ID ALZHEIMERS-DISEASE; INTERVENTION; DEMENTIA; EEG; METAANALYSIS;
   PROGRESSION; MEMORY; YOUNG
AB Introduction: Recent research from both human and animal studies confirms that cognitive training gains a considerable effect on multiple cognitive domains in older adults with mild cognitive impairment. Previous studies have yet paid scant attention to executive function training. Little is known about whether this specific benefit translates to maintaining long-term effectiveness and transfer effects are. This study is designed as an effort to address this issue.
   Objective: The program aimed to evaluate the effect of process-based multi-task cognitive training on executive function and further explore its long-term effects and transfer effects in older adults with MCI. Furthermore, we will explore the neural correlates latent the changed performances underlying the cognitive intervention.
   Methods: This program is a single-blinded, randomized, prospective clinical trial to test the effect of process-based multi-task cognitive training in older adults with MCI. Ninety participants with MCI will be recruited and randomly assigned to the cognitive training group (n=45) and the wait-list control group (n=45). The cognitive training group will receive 10 weeks of process-based multi-task cognitive training and health education twice a week, at 40 similar to 60 min per session. While the wait-list control group will only receive 10 weeks of health education during the research period. The effect is measured using the executive function, neuropsychological assessment performance and related brain activity assessed with electroencephalogram parameters (slowness and complexity of the EEG) at baseline, after 10 weeks of training, and a 3-month follow-up.
   Results: The study is currently ongoing. Recruitment began in March 2019 and will conclude at the end of 2020. Effects of the process-based multi-task cognitive training on executive function in older adults with MCI will be described in intention-to-treat analysis and protocol set principle. We will also explore the potential long-term effects and transfer effects.
   Discussion: If a process-based multi-task cognitive training program results in positive changes to executive function in older adults with MCI, this might provide a viable and potential approach to delay the cognitive decline.
C1 [Zhao, Xia; Wang, Lina; Ge, Chenxi; Liu, Xiaoshen] Huzhou Univ, Huzhou Ctr Hosp, Sch Med, Huzhou, Peoples R China.
   [Chen, Mei] Huzhou Rehabil Hosp, Dept Nursing, Huzhou, Peoples R China.
   [Zhang, Chen] Community Hlth Serv Ctr Renhuangshan, Dept Gen Med, Huzhou, Peoples R China.
C3 Huzhou University
RP Wang, LN (corresponding author), Huzhou Univ, Huzhou Ctr Hosp, Sch Med, Huzhou, Peoples R China.
EM aring2000@163.com
FU National Natural Science Foundation of China [71704053]; China
   Scholarship Council Foundation [201908330251]; Zhejiang provincial
   Natural Science Foundation of China [LQ17G030002]; Zhejiang Provincial
   College Students Scientific and Technological Innovation Activities
   [2019R431044]
FX This work was supported by the National Natural Science Foundation of
   China (NO.71704053), China Scholarship Council Foundation
   (NO.201908330251), the Zhejiang provincial Natural Science Foundation of
   China (NO. LQ17G030002) and the Zhejiang Provincial College Students
   Scientific and Technological Innovation Activities (2019R431044). The
   funding bodies did not participate neither in the design of the study
   nor in the data analysis and manuscript elaboration.
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NR 52
TC 5
Z9 6
U1 2
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 23
PY 2020
VL 11
AR 655
DI 10.3389/fpsyt.2020.00655
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA NB5AR
UT WOS:000560525500001
PM 32848901
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Buschert, VC
   Giegling, I
   Merensky, W
   Jolk, S
   Teipel, SJ
   Hampel, H
   Rujescu, D
   Buerger, K
AF Buschert, V. C.
   Giegling, I.
   Merensky, W.
   Jolk, S.
   Teipel, S. J.
   Hampel, H.
   Rujescu, D.
   Buerger, K.
TI Long-term observation of a multicomponent cognitive intervention in
   amnestic mild cognitive impairment (aMCI)
SO PHARMACOPSYCHIATRY
LA English
DT Meeting Abstract
CT 27th Symposium of the AGNP
CY OCT 05-08, 2011
CL Munich, GERMANY
C1 [Buschert, V. C.; Giegling, I.; Merensky, W.; Jolk, S.; Rujescu, D.] Univ Munich, Dept Psychiat, D-80539 Munich, Germany.
   [Teipel, S. J.] Univ Rostock, Dept Psychiat, D-2500 Rostock 1, Germany.
   [Hampel, H.] Goethe Univ, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany.
   [Buerger, K.] Univ Munich, Inst Stroke & Dementia Res, D-80539 Munich, Germany.
C3 University of Munich; University of Rostock; Goethe University
   Frankfurt; University of Munich
RI Giegling, Ina/ABA-3677-2021; Rujescu, Dan/GRS-3875-2022
NR 0
TC 0
Z9 0
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0176-3679
J9 PHARMACOPSYCHIATRY
JI Pharmacopsychiatry
PD SEP
PY 2011
VL 44
IS 6
DI 10.1055/s-0031-1292455
PG 1
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Psychiatry
GA 836CP
UT WOS:000296086300039
DA 2023-08-17
ER

PT J
AU Fields, JA
   Lunde, AM
   Hanna, SM
   Smith, GE
   Greenaway, MC
AF Fields, Julie A.
   Lunde, Angela M.
   Hanna, Sherrie M.
   Smith, Glenn E.
   Greenaway, Melanie C.
TI Effects of Behavioral Intervention on Caregivers of Individuals with
   Mild Cognitive Impairment
SO JOURNAL OF WOMENS HEALTH
LA English
DT Meeting Abstract
C1 [Fields, Julie A.; Lunde, Angela M.; Hanna, Sherrie M.; Smith, Glenn E.] Emory Univ, Sch Med, Dept Psychiat & Psychol, Mayo Clin, Atlanta, GA 30322 USA.
   [Greenaway, Melanie C.] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA.
C3 Emory University; Mayo Clinic; Emory University
NR 0
TC 0
Z9 0
U1 0
U2 6
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD OCT
PY 2011
VL 20
IS 10
BP 1391
EP 1391
PG 1
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 833IQ
UT WOS:000295877900020
DA 2023-08-17
ER

PT J
AU Lim, YM
AF Lim, YM
TI Nursing intervention for grooming of elders with mild cognitive
   impairments in Korea
SO GERIATRIC NURSING
LA English
DT Article
ID DEMENTIA; BEHAVIOR
C1 Yonsei Univ, Wonju Coll Med, Dept Nursing, Kangwon Do, South Korea.
C3 Yonsei University
RP Lim, YM (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Nursing, Kangwon Do, South Korea.
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PU MOSBY, INC
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PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0197-4572
J9 GERIATR NURS
JI Geriatr. Nurs.
PD JAN-FEB
PY 2003
VL 24
IS 1
BP 11
EP 15
DI 10.1067/mgn.2003.9
PG 5
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA 651ZH
UT WOS:000181353500013
PM 12598860
DA 2023-08-17
ER

PT J
AU Torossian, M
   Fiske, SM
   Jacelon, CS
AF Torossian, Maral
   Fiske, Sarah Marie
   Jacelon, Cynthia S.
TI Sleep, Mild Cognitive Impairment, and Interventions for Sleep
   Improvement: An Integrative Review
SO WESTERN JOURNAL OF NURSING RESEARCH
LA English
DT Review
DE sleep quality; sleep disturbances; sleep interventions; mild cognitive
   impairment (MCI); Alzheimer&#8217; s disease; cognitive impairment;
   older adults
ID AMYLOID-BETA; DISTURBANCE; PATTERNS; DISEASE
AB Sleep disturbance in mild cognitive impairment (MCI) is associated with progression to Alzheimer's disease (AD), more severe AD symptoms, and worse health outcomes. The aim of this review was to examine the relationship between sleep and MCI, and the effectiveness of sleep improvement interventions for older adults with MCI or AD. An integrative review was conducted using four databases, and findings were analyzed using an iterative process. Findings from 24 studies showed that alterations in sleep increased the risk of MCI and that the sleep quality of individuals with MCI or AD was poorer than healthy controls. Changes in brain anatomy were also observed in healthy older adults with sleep disturbances. Examined interventions were shown to be effective in improving sleep. Screening for sleep disturbances in individuals with MCI/AD is crucial to mitigate neurodegenerative or neurobehavioral risks in this population.
C1 [Torossian, Maral; Fiske, Sarah Marie; Jacelon, Cynthia S.] Univ Massachusetts Amherst, 651 N Pleasant St, Amherst, MA 01003 USA.
C3 University of Massachusetts System; University of Massachusetts Amherst
RP Torossian, M (corresponding author), Univ Massachusetts Amherst, 651 N Pleasant St, Amherst, MA 01003 USA.
EM mtorossian@umass.edu
OI Torossian, Maral R/0000-0002-7463-735X
FU National Institute of Nursing Research of the National Institutes of
   Health [P20NR016599]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Research
   reported in this publication was supported by the National Institute of
   Nursing Research of the National Institutes of Health under Award Number
   P20NR016599. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health.
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NR 57
TC 5
Z9 5
U1 0
U2 25
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0193-9459
EI 1552-8456
J9 WESTERN J NURS RES
JI West. J. Nurs. Res.
PD NOV
PY 2021
VL 43
IS 11
BP 1051
EP 1060
AR 0193945920986907
DI 10.1177/0193945920986907
EA JAN 2021
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA WC6IG
UT WOS:000626676400001
PM 33455559
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Tan, RS
   Pu, SJ
   Culberson, JW
AF Tan, RS
   Pu, SJ
   Culberson, JW
TI Role of androgens in mild cognitive impairment and possible
   interventions during andropause
SO MEDICAL HYPOTHESES
LA English
DT Article
ID DEHYDROEPIANDROSTERONE-SULFATE CONCENTRATIONS; CEREBRAL
   GLUCOSE-METABOLISM; ALZHEIMERS-DISEASE; AMYLOID PROTEIN; TESTOSTERONE;
   MEMORY; DHEAS; BRAIN; PRECURSOR; NEUROSTEROIDS
AB Mild cognitive impairment (MCI) is becoming fashionable as a diagnosis, representing a state of cognitive decline associated with negligible functional loss. MCI is important as it often precedes Alzheimer's disease (AD). Recognizing MCI may lead to preventive strategies that can delay the onset of AD. Many patients who transition into andropause report problems with their memory. There is strong evidence from basic sciences and epidemiological studies that both estrogens and androgens play a protective role in neurodegeneration. The evidence from small prospective clinical trials lends support to the role of hormones in improving cognitive function. The improvement in cognitive function with hormones is subtle and often not measurable on standard neuropsychological batteries. Patients have reported memory improvements in both declarative and procedural domains after being on hormonal replacement. Functional changes and vascular changes can be detected after hormonal replacement with more sophisticated imaging of the brain like PET scans. We hypothesize androgens and perhaps selective androgen receptor modulators as future treatment options for MCI in aging mates. (C) 2003 Published by Elsevier Ltd.
C1 Univ Texas, Sch Med, Dept Family & Community Med, Geriatr Med Program, Houston, TX 77030 USA.
   Univ Texas, Sch Med, Dept Family & Community Med, Androl Program, Houston, TX 77030 USA.
   Garden Terrace Alzheimers Ctr, Houston, TX 77030 USA.
C3 University of Texas System; University of Texas System
RP Tan, RS (corresponding author), Univ Texas, Sch Med, Dept Family & Community Med, Geriatr Med Program, 6431 Fannin St,JJL Suite 308, Houston, TX 77030 USA.
EM robert.s.tan@uth.tmc.edu
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NR 46
TC 7
Z9 8
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2004
VL 62
IS 1
BP 14
EP 18
DI 10.1016/S0306-9877(03)00224-X
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 775DE
UT WOS:000189024800004
PM 14728998
DA 2023-08-17
ER

PT J
AU Agarwal, A
   Chauhan, K
AF Agarwal, Aditika
   Chauhan, Komal
TI Vitamin B12 Supplementation for Assuaging Mild Cognitive Impairment: an
   Elders' Interventional Study
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Meeting Abstract
DE Mild Cognitive impairment; Vitamin B12; Elderly
C1 [Agarwal, Aditika] Maharaja Sayajirao Univ Baroda, Dept Nutr & Foods, Vadodara, Gujarat, India.
   [Chauhan, Komal] Maharaja Sayajirao Univ Baroda, Dept Food & Nutr, Vadodara, Gujarat, India.
C3 Maharaja Sayajirao University Baroda; Maharaja Sayajirao University
   Baroda
OI Agarwal, Aditika/0000-0002-0007-024X
NR 0
TC 0
Z9 0
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2015
VL 67
SU 1
MA 149/921
BP 417
EP 418
PG 2
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DK5VM
UT WOS:000374988802053
DA 2023-08-17
ER

PT J
AU Chen, P
   Pan, ZM
   Yi, X
   Li, CH
AF Chen, Ping
   Pan, Zhengmao
   Yi, Xiang
   Li, Canhui
TI EVALUATION SCALE AND INTERVENTION EFFECT OF MILD COGNITIVE IMPAIRMENT IN
   THE ELDERLY
SO PSYCHIATRIA DANUBINA
LA English
DT Meeting Abstract
C1 [Chen, Ping; Yi, Xiang; Li, Canhui] Yueyang Vocat Tech Coll, Sch Nursing, Yueyang 414000, Peoples R China.
   [Pan, Zhengmao] Yueyang Vocat Tech Coll, Off Party & Govt, Yueyang 414000, Peoples R China.
NR 0
TC 0
Z9 0
U1 0
U2 5
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
EI 1849-0867
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2022
VL 34
SU 1
BP S776
EP S777
PG 2
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 0O6ZV
UT WOS:000783672900539
DA 2023-08-17
ER

PT J
AU Lin, YQ
   Li, BY
   Tang, HD
   Xu, Q
   Wu, YC
   Cheng, Q
   Li, CB
   Xiao, SF
   Shen, L
   Tang, WG
   Yu, H
   He, NY
   Lin, HW
   Yan, FH
   Cao, WW
   Yang, SL
   Liu, Y
   Zhao, W
   Lu, D
   Jiao, B
   Xiao, XW
   Zhou, L
   Chen, SD
AF Lin, Yiqi
   Li, Binyin
   Tang, Huidong
   Xu, Qun
   Wu, Yuncheng
   Cheng, Qi
   Li, Chunbo
   Xiao, Shifu
   Shen, Lu
   Tang, Weiguo
   Yu, Hui
   He, Naying
   Lin, Huawei
   Yan, Fuhua
   Cao, Wenwei
   Yang, Shilin
   Liu, Ye
   Zhao, Wei
   Lu, Dong
   Jiao, Bin
   Xiao, Xuewen
   Zhou, Lin
   Chen, Shengdi
TI Shanghai cognitive intervention of mild cognitive impairment for
   delaying progress with longitudinal evaluation-a prospective, randomized
   controlled study (SIMPLE): rationale, design, and methodology
SO BMC NEUROLOGY
LA English
DT Article
DE Mild cognitive impairment; Cognitive training; China; Longitude
   evaluation; Randomized controlled trial
ID PROBABLE ALZHEIMERS-DISEASE; MEDIAL TEMPORAL-LOBES; DIAGNOSTIC-VALUE;
   OLDER-ADULTS; DEMENTIA; INDIVIDUALS; PREVALENCE; ATROPHY; MEMORY; CHINA
AB Background: Mild cognitive impairment is an early stage of Alzheimer's disease. Increasing evidence has indicated that cognitive training could improve cognitive abilities of MCI patients in multiple cognitive domains, making it a promising therapeutic approach for MCI. However, the effect of long-time training has not been widely explored. It is also necessary to evaluate the extent how it could reduce the convertion rate from MCI to AD.
   Methods/design: The SIMPLE study is a multicenter, randomized, single-blind prospective clinical trial assessing the effects of computerized cognitive training on different cognitive domains in MCI patients. It is carried out in 7 centers in China. The study population includes patients aged 50-85, and they are randomly allocated to the training or control group. The primary outcome is to compare the conversion rate of MCI within 36-month follow-up. Structural and functional MRI will be used to interpret the effect of cognitive training. The cognitive training comprises a variety of games related with cognitive domains such as attention, memory, visualspatial ability and executive function. We cautiously set 50% reduction in the rate of conversion as estimated effect. With 80-90% statistical power and 12% as the overall probability of conversion within the study period, 600-800 patients are finally required in the study. The first patent has been recruited in April 2017.
   Discussion: Previous studies suggested the benefit of cognitive training for MCI, but neither long-time nor Chinese culture were investigated. The SIMPLE designs and utilizes an improved computerized cognitive training approach and assesses its effects on MCI progress. In addition, neural activities explaining the effects on cognition function changes will be revealed, which could in turn to imply more useful therapeutic approaches.
C1 [Chen, Shengdi] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Neurol, Shanghai 200025, Peoples R China.
   Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Inst Neurol, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Chen, SD (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Neurol, Shanghai 200025, Peoples R China.
EM chen_sd@medmail.com.cn
RI Jiao, Bin/HHZ-6629-2022; Lin, Huawei/ABE-5171-2021
OI Lin, Huawei/0000-0002-2965-3158; Lin, Yiqi/0000-0003-1914-7726
FU Clinical Research Center, Shanghai Jiao Tong University School of
   Medicine [DLY201603]; National Key R&D Program of China [2016YFC1305804]
FX The SIMPLE trial is supported by the Clinical Research Center, Shanghai
   Jiao Tong University School of Medicine (DLY201603) and National Key R&D
   Program of China (2016YFC1305804), which has no influence on the study
   design, data collection, data analysis, and final drafting of this
   manuscript.
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NR 29
TC 5
Z9 5
U1 3
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2377
J9 BMC NEUROL
JI BMC Neurol.
PD JUL 24
PY 2018
VL 18
AR 103
DI 10.1186/s12883-018-1100-x
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GO1UU
UT WOS:000439744800001
PM 30041656
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Reijnders, J
   van Heugten, C
   van Boxtel, M
AF Reijnders, Jennifer
   van Heugten, Caroline
   van Boxtel, Martin
TI Cognitive interventions in healthy older adults and people with mild
   cognitive impairment: A systematic review
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Systematic review; Cognitive interventions; Healthy older adults; Mild
   cognitive impairment; Randomized controlled trials
ID MEMORY TRAINING-PROGRAM; PERFORMANCE; AGE; PLASTICITY; EFFICACY;
   IMPROVE; IMPACT
AB Given that the research area of cognitive intervention studies in the aging population is growing rapidly, it is important to review and gauge more recent intervention studies, in order to determine the evidence for the effectiveness of cognitive interventions. The purpose of the present review was to update the recent systematic reviews of Papp et al. (2009) and Martin et al. (2011), to evaluate the effectiveness of cognitive interventions in healthy older adults and people with MCI, by taking into account the methodological quality of the interventions studies. A systematic review of randomized controlled trials (RCT) and clinical studies published between August 2007 and February 2012 in Pubmed and PsychINFO was performed. The quality of the included RCTs was assessed according to the CONSORT criteria for RCTs. A total of thirty-five studies were included; twenty-seven RTCs and eight clinical studies. The content of the intervention studies differed widely, as did the methodological quality of the included RCTs, but was considerably low with an average of 44% of the Consort items included. The results show evidence that cognitive training can be effective in improving various aspects of objective cognitive functioning; memory performance, executive functioning, processing speed, attention, fluid intelligence, and subjective cognitive performance. However, the issue whether the effects of cognitive interventions generalize to improvement in everyday life activities is still unresolved and needs to be addressed more explicitly in future research. (c) 2012 Elsevier B.V. All rights reserved.
C1 [Reijnders, Jennifer; van Heugten, Caroline; van Boxtel, Martin] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Med Ctr, NL-6200 MD Maastricht, Netherlands.
   [van Heugten, Caroline; van Boxtel, Martin] Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University; Maastricht University
RP Reijnders, J (corresponding author), Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM jennifer.reijnders@maastrichtuniversity.nl
FU National Initiative Brain & Cognition (NIBC); Netherlands Organization
   for Scientific Research (NWO)
FX This study was funded by the National Initiative Brain & Cognition
   (NIBC) and the Netherlands Organization for Scientific Research (NWO).
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NR 47
TC 285
Z9 294
U1 6
U2 169
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD JAN
PY 2013
VL 12
IS 1
BP 263
EP 275
DI 10.1016/j.arr.2012.07.003
PN 2013
PG 13
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA 092MD
UT WOS:000315125800025
PM 22841936
OA Green Published
DA 2023-08-17
ER

PT J
AU Joo, SH
   Yun, SH
   Kang, DW
   Hahn, CT
   Lim, HK
   Lee, CU
AF Joo, Soo Hyun
   Yun, Se Hee
   Kang, Dong Woo
   Hahn, Chang Tae
   Lim, Hyun Kook
   Lee, Chang Uk
TI Body Mass Index in Mild Cognitive Impairment According to Age, Sex,
   Cognitive Intervention, and Hypertension and Risk of Progression to
   Alzheimer's Disease
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE body mass index; mild cognitive impairment; Alzheimer's disease;
   intervention; CERAD
ID RANDOMIZED CONTROLLED-TRIAL; WEIGHT-LOSS; LATE-LIFE; REPLACEMENT
   THERAPY; DEMENTIA; OBESITY; MIDLIFE; METAANALYSIS; CLASSIFICATION;
   ASSOCIATION
AB Introduction: Mild cognitive impairment (MCI) is a prodromal stage of dementia. The association of body mass index (BMI) and progression to Alzheimer's disease (AD) in MCI subjects according to age, sex, and cognitive intervention remains unknown. We investigated the relationship between BMI and the risk of progression to AD in subjects with MCI, as well as the effect of BMI on progression to AD depending on age, sex, cognitive intervention, and chronic diseases.
   Methods: Three hundred and eighty-eight MCI subjects were followed for 36.3 +/- 18.4 months, prospectively. They underwent neuropsychological testing more than twice during the follow-up period. The MCI subjects were categorized into underweight, normal weight, overweight, and obese subgroups. The associations between baseline BMI and progression to AD over the follow-up period were estimated using Cox proportional hazard regression models. Data were analyzed after stratification by age, sex, cognitive intervention, and chronic diseases.
   Results: After adjustment for the covariates, the underweight MCI group had a higher risk of progression to AD [hazard ratio (HR): 2.38, 95% confidence interval (CI): 1.17-4.82] relative to the normal weight group. After stratifying by age, sex, cognitive intervention, and chronic diseases, this effect remained significant among females (HR: 3.15, 95% CI: 1.40-7.10), the older elderly >= 75 years old (HR: 3.52, 95% CI: 1.42-8.72), the non-intervention group (HR: 3.06, 95%CI: 1.18-7.91), and the hypertensive group (HR: 4.71, 95% CI: 1.17-18.99).
   Conclusion: These data indicate that underweight could be a useful marker for identifying individuals at increased risk for AD in MCI subjects. This association is even stronger in females, older elderly subjects, the non-cognitive intervention group, and the hypertensive group.
C1 [Joo, Soo Hyun; Kang, Dong Woo; Lee, Chang Uk] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Psychiat, Seoul, South Korea.
   [Yun, Se Hee] Seocho Ctr Dementia, Seoul, South Korea.
   [Hahn, Chang Tae] Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Psychiat, Seoul, South Korea.
   [Lim, Hyun Kook] Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Psychiat, Seoul, South Korea.
C3 Catholic University of Korea; Seoul St. Mary's Hospital; Catholic
   University of Korea; Catholic University of Korea
RP Lee, CU (corresponding author), Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Psychiat, Seoul, South Korea.
EM jihan@catholic.ac.kr
RI Lee, Chang/HME-1129-2023; Kang, Dong woo/AAK-2043-2021
OI Kang, Dong Woo/0000-0003-3289-075X
FU Ministry of Trade, Industry and Energy (MOTIE, Korea) under Industrial
   Technology Innovation Program [10062378]; Korea Evaluation Institute of
   Industrial Technology (KEIT) [10062378] Funding Source: Korea Institute
   of Science & Technology Information (KISTI), National Science &
   Technology Information Service (NTIS)
FX This research was supported by the Ministry of Trade, Industry and
   Energy (MOTIE, Korea) under Industrial Technology Innovation Program No.
   10062378.
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NR 36
TC 35
Z9 35
U1 4
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 17
PY 2018
VL 9
AR 142
DI 10.3389/fpsyt.2018.00142
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GD0QR
UT WOS:000430205800001
PM 29719518
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Sherman, DS
   Durbin, KA
   Ross, DM
AF Sherman, Dale S.
   Durbin, Kelly A.
   Ross, David M.
TI Meta-Analysis of Memory-Focused Training and Multidomain Interventions
   in Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Cognitive dysfunction; cognitive remediation; meta-analysis;
   neuropsychology; rehabilitation
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; CHOLINESTERASE-INHIBITORS;
   STIMULATION; RISK; MCI; INDIVIDUALS; HEALTHY; PROGRAMS; EFFICACY
AB Background: Meta-analysis examining the efficacy of cognitive interventions on neuropsychological outcomes have suggested interventions that focus on memory may actually provide greater benefit against the cognitive declines associated with mild cognitive impairment (MCI). However, it remains unclear if memory-based training would be more effective at addressing the cognitive deficits associated with MCI than multidomain forms of intervention.
   Objective: A meta-analytic review and subgroup analysis was conducted to examine the effects of cognitive training in individuals diagnosed with MCI and to compare the efficacy of memory-based training with multidomain interventions.
   Methods: A total of 32 randomized controlled trials met inclusion criteria for the meta-analysis, which included 9 studies on memory-focused training and 17 studies on multidomain interventions.
   Results: We found significant, large effects for memory-focused training (Hedges' g observed = 0.947; 95% CI [-1.668, 3.562]; Z = 2.517; p = 0.012) and significant, moderate effects for multidomain interventions (Hedges' g observed = 0.420; 95% CI [-0.4491, 1.2891]; Z = 3.525; p < 0.001). A subgroup analysis found significant point estimates for memory-based forms of training and multidomain interventions, with memory-based forms of content yielding significantly greater summary effects than multidomain interventions (SMD Z = 2.162; p = 0.031, two-tailed; all outcomes). There was no difference between effect sizes when comparing outcomes limited to its respective domain.
   Conclusion: Overall, these findings suggest that, while both interventions were beneficial, treatment interventions that were strictly memory-based were more effective at improving cognition in individuals diagnosed with MCI than interventions that targeted multiple cognitive domains.
C1 [Sherman, Dale S.; Durbin, Kelly A.; Ross, David M.] Cedars Sinai Med Ctr, Dept Phys Med & Rehabil, 444 S San Vicente Blvd,Suite 103, Los Angeles, CA 90048 USA.
   [Sherman, Dale S.] Univ Southern Calif, Rossier Sch Educ, Los Angeles, CA 90007 USA.
   [Durbin, Kelly A.] Univ Southern Calif, Dept Psychol, Los Angeles, CA 90007 USA.
   [Ross, David M.] Loma Linda Univ, Dept Psychol, Loma Linda, CA 92350 USA.
C3 Cedars Sinai Medical Center; University of Southern California;
   University of Southern California; Loma Linda University
RP Sherman, DS (corresponding author), Cedars Sinai Med Ctr, Dept Phys Med & Rehabil, 444 S San Vicente Blvd,Suite 103, Los Angeles, CA 90048 USA.
EM dale.sherman@cshs.org
RI Durbin, Kelly/AAF-7224-2019
OI Durbin, Kelly/0000-0002-8129-8288
FU National Institute on Aging [F31AG057174]
FX This work was supported by the National Institute on Aging under Grant
   F31AG057174.
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NR 103
TC 4
Z9 4
U1 1
U2 14
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2020
VL 76
IS 1
BP 399
EP 421
DI 10.3233/JAD-200261
PG 23
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA MF4TV
UT WOS:000545337600035
PM 32508325
DA 2023-08-17
ER

PT J
AU Wright, KD
   Klatt, MD
   Adams, IR
   Nguyen, C
   Tan, A
   Scharre, D
   Lorraine, M
   Monroe, TB
AF Wright, Kathy D.
   Klatt, Maryanna D.
   Adams, Ingrid R.
   Nguyen, Christopher
   Tan, Alai
   Scharre, Douglas
   Lorraine, Mion
   Monroe, Todd B.
TI DESIGNING A BEHAVIORAL INTERVENTION FOR AFRICAN AMERICANS WITH MILD
   COGNITIVE IMPAIRMENT AND HYPERTENSION
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Meeting Abstract
C1 [Wright, Kathy D.; Tan, Alai; Lorraine, Mion; Monroe, Todd B.] Ohio State Univ, Coll Nursing, Columbus, OH 43210 USA.
   [Klatt, Maryanna D.] Ohio State Univ, Clin Family Med, Columbus, OH 43210 USA.
   [Adams, Ingrid R.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
   [Nguyen, Christopher] Ohio State Univ, Wexner Med Ctr, Dept Psychiat & Behav Hlth, Columbus, OH 43210 USA.
   [Scharre, Douglas] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University; University System of Ohio; Ohio State University; University
   System of Ohio; Ohio State University
EM wright.2104@osu.edu
RI Wright, Kathy/IAR-2883-2023; Monroe, Todd/AAK-7816-2021
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD MAY
PY 2020
VL 54
SU 1
MA B104
BP S260
EP S260
PG 1
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA MG8ED
UT WOS:000546262400546
DA 2023-08-17
ER

PT J
AU Martin, M
   Clare, L
   Altgassen, AM
   Cameron, MH
   Zehnder, F
AF Martin, Mike
   Clare, Linda
   Altgassen, Anne Mareike
   Cameron, Michelle H.
   Zehnder, Franzisca
TI Cognition-based interventions for healthy older people and people with
   mild cognitive impairment
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID MEMORY ENHANCEMENT PROGRAM; 3-YEAR FOLLOW-UP; REHABILITATION PROGRAM;
   DIAGNOSTIC-CRITERIA; LEARNING MNEMONICS; ALZHEIMERS-DISEASE; FLUID
   INTELLIGENCE; TRAINING-PROGRAM; EVERYDAY MEMORY; FREE-RECALL
AB Background
   Evidence from some, but not all non-randomised studies suggest the possibility that cognitive training may influence cognitive functioning in older people. Due to the differences among cognitive training interventions reported in the literature, giving a general overview of the current literature remains difficult.
   Objectives
   To systematically review the literature and summarize the effect of cognitive training interventions on various domains of cognitive function (ie memory, executive function, attention and speed) in healthy older people and in people with mild cognitive impairment.
   Search strategy
   The CDCIG Specialized Register was searched on 30 September 2007 for all years up to December 2005. The Cochrane Library, MEDLINE, EMBASE, PsycINFO and CINAHL were searched separately on 30 September 2007 to find trials with healthy people. These results were supplemented by searches from January 1970 to September 2007 in PsychInfo/Psyndex, ISI Web of Knowledge and PubMed.
   Selection criteria
   RCTs of interventions evaluating the effectiveness of cognitive training for healthy older people and people with mild cognitive impairment from 1970 to 2007 that met inclusion criteria were selected.
   Data collection and analysis
   Authors independently extracted data and assessed trial quality. Meta-analysis was performed when appropriate.
   Main results
   Only data on memory training could be pooled for analysis. Within this domain, training interventions were grouped according to several outcome variables. Results showed that for healthy older adults, immediate and delayed verbal recall improved significantly through training compared to a no-treatment control condition. We did not find any specific memory training effects though as the improvements observed did not exceed the improvement in the active control condition. For individuals with mild cognitive impairment, our analyses demonstrate the same pattern. Thus, there is currently little evidence on the effectiveness and specificity of memory interventions for healthy older adults and individuals with mild cognitive impairment.
   Authors' conclusions
   There is evidence that cognitive interventions do lead to performance gains but none of the effects observed could be attributable specifically to cognitive training, as the improvements observed did not exceed the improvement in active control conditions. This does not mean that longer, more intense or different interventions might not be effective, but that those which have been reported thus far have only limited effect. We therefore suggest more standardized study protocols in order to maximize comparability of studies and to maximize the possibility of data pooling - also in other cognitive domains than memory.
C1 [Martin, Mike; Zehnder, Franzisca] Univ Zurich, Inst Psychol, Lehrstuhl Gerontopsychol, CH-8050 Zurich, Switzerland.
   [Clare, Linda] Univ Wales Bangor, Sch Psychol, Bangor, Gwynedd, Wales.
   [Altgassen, Anne Mareike] Univ Dresden, Dresden, Germany.
   [Cameron, Michelle H.] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA.
C3 University of Zurich; Bangor University; Technische Universitat Dresden;
   Oregon Health & Science University
RP Martin, M (corresponding author), Univ Zurich, Inst Psychol, Lehrstuhl Gerontopsychol, Binzmuhlestr 14-24, CH-8050 Zurich, Switzerland.
EM m.martin@psychologie.uzh.ch
RI Altgassen, Mareike/AAN-1767-2020; Altgassen, Mareike/J-3048-2012
OI Altgassen, Mareike/0000-0002-2644-8298; Cameron,
   Michelle/0000-0001-7971-4679; Clare, Linda/0000-0003-3989-5318
FU Institute of Psychology, University of Zurich, Switzerland; School of
   Psychology, University of Wales, Bangor, UK
FX Institute of Psychology, University of Zurich, Switzerland.; School of
   Psychology, University of Wales, Bangor, UK.
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NR 138
TC 235
Z9 241
U1 3
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2011
IS 1
AR CD006220
DI 10.1002/14651858.CD006220.pub2
PG 48
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 708VQ
UT WOS:000286392800030
PM 21249675
DA 2023-08-17
ER

PT J
AU Li, F
   Parsons, J
   Peri, K
   Yu, A
   Cheung, G
AF Li, Fei
   Parsons, John
   Peri, Kathy
   Yu, An
   Cheung, Gary
TI Effects of cognitive interventions on quality of life among adults with
   mild cognitive impairment: A systematic review and meta-analysis of
   randomised controlled trials
SO GERIATRIC NURSING
LA English
DT Review
DE Mild cognitive impairment; Cognitive interventions; Quality of life;
   Meta-analysis
ID ALZHEIMERS-DISEASE; HEALTH; INDIVIDUALS; OUTCOMES; RISK; REHABILITATION;
   DEMENTIA; PROGRAMS; EXERCISE; EFFICACY
AB Background: There is considerable research exploring the impact of cognitive interventions on cognition in people with mild cognitive impairment (MCI). However, the impact on quality of life (QOL) is not routinely reported. As QOL is a key predictor of health outcomes, it is important to determine the evidence supporting cognitive interventions for improving QOL in people with MCI.
   Objective: To evaluate the evidence on the effectiveness of cognitive interventions for improving QOL among people with MCI.
   Design: Systematic review and meta-analysis.
   Methods: A systematic database search was conducted from inception to December 11, 2021, using four databases. Quality assessment was conducted, and data on the characteristics of the studies and the effects on QOL were extracted. Subgroup analyses and meta-regression were conducted to elucidate the effects of potential moderator variables on QOL measures.
   Results: Of the 1550 records initially identified, 17 studies met the criteria for the final meta-analysis. The findings revealed that cognitive interventions produced moderate gains in overall QOL compared to the control group at the posttest (standardized mean difference (SMD): 0.53, 95% confidence interval (CI): [0.23, 0.84]), but no statistically significant differences were found at the end of follow-up (SMD: 0.40, 95% CI: [-0.15,0.94]). Furthermore, the effects of cognitive interventions were moderated by intervention duration, session duration, and study location. However, intervention types, session frequency, intervention components, control condition, total number of sessions, types of QOL measures, and responders to QOL-AD had no statistically significant effects on QOL outcome.
   Conclusions: Cognitive interventions have positive effects on QOL among adults with MCI. However, the high heterogeneity of the included studies calls for more well-designed cognitive intervention trials to examine the association between QOL and relevant moderators. (C) 2022 Elsevier Inc. All rights reserved.
C1 [Li, Fei; Parsons, John; Peri, Kathy] Univ Auckland, Fac Med & Hlth Sci, Sch Nursing, Level 2,Bldg 505,85 Pk Rd, Auckland 1142, New Zealand.
   [Li, Fei] Guangxi Med Univ, Sch Nursing, Nanning, Guangxi, Peoples R China.
   [Cheung, Gary] Univ Auckland, Fac Med & Hlth Sci, Sch Med, Dept Psychol Med, Auckland, New Zealand.
   [Yu, An] Univ Waikato, Te Huataki Waiora Sch Hlth, Div Hlth Engn Comp & Sci, Hamilton, New Zealand.
C3 University of Auckland; Guangxi Medical University; University of
   Auckland; University of Waikato
RP Li, F (corresponding author), Univ Auckland, Fac Med & Hlth Sci, Sch Nursing, Level 2,Bldg 505,85 Pk Rd, Auckland 1142, New Zealand.
EM fli745@aucklanduni.ac.nz
OI Yu, An/0000-0001-9290-1516
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NR 54
TC 0
Z9 0
U1 3
U2 13
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4572
EI 1528-3984
J9 GERIATR NURS
JI Geriatr. Nurs.
PD SEP-OCT
PY 2022
VL 47
BP 39
EP 50
DI 10.1016/j.gerinurse.2022.06.009
EA JUL 2022
PG 12
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA 3G3MK
UT WOS:000831259000006
PM 35816984
DA 2023-08-17
ER

PT J
AU Al Mahmud, A
   Slikboer, R
   Stargatt, J
   Bhar, S
AF Al Mahmud, Abdullah
   Slikboer, Reneta
   Stargatt, Jennifer
   Bhar, Sunil
TI Computer-based cognitive interventions for mild cognitive impairment and
   dementia in older adults: protocol for a systematic review of published
   studies and meta-analysis
SO SYSTEMATIC REVIEWS
LA English
DT Review
DE Dementia; Cognition; Impairment; Computer-based intervention;
   Technology; Stimulation; Therapy
ID PREVALENCE
AB Background A growing number of older adults experience mild cognitive impairment (MCI) and dementia. Recent technological advances allow for traditional cognitive interventions to be administered via computers and other devices. The aim of the proposed systematic review and meta-analyses is to determine the efficacy of computerised cognitive interventions for MCI and dementia in older adults. Methods We will systematically search electronic databases and reference lists to identify randomised controlled trials. We will include studies that examine the use of computer-based cognitive interventions for adults aged over 60 with MCI or dementia. Primarily outcomes are global and domain-specific cognitive function. Secondary outcomes are attitudes (usability, understandability, acceptability of the intervention), mood and quality of life. Risk of bias will be assessed. Finally, the summary effect sizes will be reported. Discussion This systematic review will summarise existing high-quality primary studies on computerised-cognitive interventions for MCI and dementia. Results from this review will provide the basis for future research in developing computer-based interventions for this population.
C1 [Al Mahmud, Abdullah; Slikboer, Reneta; Stargatt, Jennifer; Bhar, Sunil] Swinburne Univ Technol, Melbourne, Vic, Australia.
C3 Swinburne University of Technology
RP Al Mahmud, A (corresponding author), Swinburne Univ Technol, Melbourne, Vic, Australia.
EM aalmahmud@swin.edu.au
RI Mahmud, Abdullah Al/C-7023-2008; Bhar, Sunil/AAX-9183-2021
OI Mahmud, Abdullah Al/0000-0002-2801-723X; Bhar,
   Sunil/0000-0001-9260-7368; Stargatt, Jennifer/0000-0002-2517-3202
FU Barbara Dicker Brain Science Foundation
FX This project was funded by the Barbara Dicker Brain Science Foundation.
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NR 17
TC 2
Z9 2
U1 2
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2046-4053
J9 SYST REV-LONDON
JI Syst. Rev.
PD SEP 6
PY 2019
VL 8
IS 1
AR 231
DI 10.1186/s13643-019-1146-x
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IV9JT
UT WOS:000484580900001
PM 31492180
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU McGrattan, AM
   McEvoy, CT
   McGuinness, B
   McKinley, MC
   Woodside, JV
AF McGrattan, A. M.
   McEvoy, C. T.
   McGuinness, B.
   McKinley, M. C.
   Woodside, J. V.
TI The effect of diet, lifestyle and/or cognitive interventions in Mild
   Cognitive Impairment: a systematic review
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Meeting Abstract
ID SUPPLEMENTATION IMPROVES MEMORY; RANDOMIZED CONTROLLED-TRIAL;
   OLDER-ADULTS
C1 [McGrattan, A. M.; McEvoy, C. T.; McGuinness, B.; McKinley, M. C.; Woodside, J. V.] Queens Univ, Ctr Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland.
C3 Queens University Belfast
RI McGrattan, Andrea/AAW-8235-2020
OI McGrattan, Andrea/0000-0003-1521-213X; McGuinness,
   Bernadette/0000-0002-7028-5633; Woodside, Jayne/0000-0002-5691-4659;
   McKinley, Michelle/0000-0003-3386-1504
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NR 12
TC 3
Z9 3
U1 1
U2 9
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PY 2017
VL 76
IS OCE3
BP E114
EP E114
DI 10.1017/S0029665117001872
PG 1
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FX9NJ
UT WOS:000426427700070
OA Bronze
DA 2023-08-17
ER

PT J
AU Jeong, JH
   Na, HR
   Choi, SH
   Kim, J
   Na, DL
   Seo, SW
   Chin, J
   Park, SA
   Kim, EJ
   Han, HJ
   Han, SH
   Yoon, SJ
   Lee, JH
   Park, KW
   Moon, SY
   Park, MH
   Choi, MS
   Han, IW
   Lee, JH
   Lee, JS
   Shim, YS
   Kim, JY
AF Jeong, Jee Hyang
   Na, Hae Ri
   Choi, Seong Hye
   Kim, Jungeun
   Na, Duk L.
   Seo, Sang Won
   Chin, Juhee
   Park, Sun Ah
   Kim, Eun-Joo
   Han, Hyun Jeong
   Han, Seol-Heui
   Yoon, Soo Jin
   Lee, Jae-Hong
   Park, Kyung Won
   Moon, So Young
   Park, Moon Ho
   Choi, Mun Seong
   Han, Il-Woo
   Lee, Jun Hong
   Lee, Jung Seok
   Shim, Yong S.
   Kim, Jeong Yeon
TI Group- and Home-Based Cognitive Intervention for Patients with Mild
   Cognitive Impairment: A Randomized Controlled Trial
SO PSYCHOTHERAPY AND PSYCHOSOMATICS
LA English
DT Article
DE Brain-derived neurotrophic factor; Brain plasticity; Cognition training;
   Conitive intervention; Mild cognitive impairment
ID QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; NEUROTROPHIC FACTOR; KOREAN
   VERSION; OLDER-ADULTS; DEMENTIA; MEMORY; BRAIN; REHABILITATION;
   VALIDATION
AB Background: We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neurotrophic factor (BDNF). Methods: In this randomized and rater-blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week. They were assessed at baseline, postintervention (PI) and at the 6-month follow-up after the intervention. The primary endpoint was the change from baseline to PI in the modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). Results: In comparison to the controls (a 0.8-point decrease), the subjects receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 0.02) showed significant improvements in the modified ADAS-Cog at PI, respectively. By the 6-month follow-up, those receiving GCI or HCI had better scores in the modified ADAS-Cog than the controls. The changes in BDNF levels significantly correlated with the changes in the modified ADAS-Cog in the GCI (r = -0.29, p = 0.02 at PI) and HCI (r = -0.27, p = 0.03 at 6-month follow-up) groups, respectively. Conclusions: The GCI and HCI resulted in cognitive improvements in aMCI. An enhanced brain plasticity may be a component of the mechanism underpinning the cognitive improvements associated with the cognitive interventions. (C) 2016 The Author(s) Published by S. Karger AG, Basel
C1 [Jeong, Jee Hyang; Kim, Jungeun] Ewha Womans Univ, Sch Med, Mokdong Hosp, Dept Neurol, Seoul, South Korea.
   [Na, Hae Ri] Bobath Mem Hosp, Dept Neurol, Songnam, South Korea.
   [Choi, Seong Hye] Inha Univ, Sch Med, Inha Univ Hosp, Dept Neurol, Inchon, South Korea.
   [Na, Duk L.; Seo, Sang Won; Chin, Juhee] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea.
   [Park, Sun Ah] Soonchunhyang Univ, Bucheon Hosp, Dept Neurol, Bucheon, South Korea.
   [Kim, Eun-Joo] Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Neurol, Busan, South Korea.
   [Kim, Eun-Joo] Pusan Natl Univ, Med Res Inst, Busan, South Korea.
   [Han, Hyun Jeong] Myongji Hosp, Dept Neurol, Goyang, South Korea.
   [Han, Seol-Heui] Konkuk Univ, Sch Med, Dept Neurol, Seoul, South Korea.
   [Yoon, Soo Jin] Eulji Univ, Sch Med, Dept Neurol, Daejeon, South Korea.
   [Lee, Jae-Hong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea.
   [Park, Kyung Won] Dong A Univ, Dong A Med Ctr, Coll Med, Dept Neurol, Busan, South Korea.
   [Moon, So Young] Ajou Univ, Sch Med, Dept Neurol, Suwon 441749, South Korea.
   [Park, Moon Ho] Korea Univ, Ansan Hosp, Coll Med, Dept Neurol, Ansan, South Korea.
   [Choi, Mun Seong] Hallym Hosp, Dept Neurol, Inchon, South Korea.
   [Han, Il-Woo] Hyoja Geriatr Hosp, Dept Neurol, Yongin, South Korea.
   [Lee, Jun Hong] Natl Hlth Insurance Corp, Ilsan Hosp, Dept Neurol, Goyang, South Korea.
   [Lee, Jung Seok] Jeju Natl Univ, Coll Med, Dept Neurol, Jeju, South Korea.
   [Shim, Yong S.] Catholic Univ Korea, Bucheon St Marys Hosp, Dept Neurol, Bucheon, South Korea.
   [Kim, Jeong Yeon] Inje Univ, Sanggye Paik Hosp, Coll Med, Dept Neurol, Seoul, South Korea.
C3 Ewha Womans University; Inha University; Inha University Hospital;
   Sungkyunkwan University (SKKU); Samsung Medical Center; Soonchunhyang
   University; Pusan National University; Pusan National University
   Hospital; Pusan National University; Myongji Hospital; Konkuk
   University; Konkuk University Medical Center; Eulji University;
   University of Ulsan; Asan Medical Center; Dong A University; Ajou
   University; Korea University; Korea University Medicine (KU Medicine);
   NHIS Ilsan Hospital; Jeju National University; Catholic University of
   Korea; Inje University
RP Choi, SH (corresponding author), Inha Univ Hosp, Dept Neurol, 7-206 3 Ga, Inchon 400711, South Korea.
EM seonghye@inha.ac.kr
OI Park, Moon Ho/0000-0002-4892-3475
FU Korea Healthcare Technology RD Project; Ministry of Health and Welfare,
   South of Korea [HI10C2020]; Original Technology Research Program for
   Brain Science through the National Research Foundation of Korea - Korean
   Government (MSIP) [2014M3C7A1064752]; Eisai Korea Inc.; National
   Research Foundation of Korea [2014M3C7A1064752] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
FX Statistical assistance was provided by Dae Hyung Lee and Young Ju Suh of
   the Clinical Research Institute, Inha University Hospital. This study
   was supported by grants from the Korea Healthcare Technology R&D
   Project, the Ministry of Health and Welfare, South of Korea (HI10C2020),
   the Original Technology Research Program for Brain Science through the
   National Research Foundation of Korea funded by the Korean Government
   (MSIP; No. 2014M3C7A1064752) and Eisai Korea Inc.
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NR 42
TC 47
Z9 49
U1 4
U2 26
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0033-3190
EI 1423-0348
J9 PSYCHOTHER PSYCHOSOM
JI Psychother. Psychosom.
PY 2016
VL 85
IS 4
BP 198
EP 207
DI 10.1159/000442261
PG 10
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA DP1OK
UT WOS:000378259100002
PM 27230861
OA hybrid
DA 2023-08-17
ER

PT J
AU Bachurin, SO
   Gavrilova, SI
   Samsonova, A
   Barreto, GE
   Aliev, G
AF Bachurin, Sergey O.
   Gavrilova, Svetlana I.
   Samsonova, Anna
   Barreto, George E.
   Aliev, Gjumrakch
TI Mild cognitive impairment due to Alzheimer disease: Contemporary
   approaches to diagnostics and pharmacological intervention
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Neurodegenerative disease; Alzheimer's disease; Multitargeting
   compounds; Disease-modifying drugs; Repositioning of old drugs; Clinical
   trial and AD treatment
ID OXIDASE INHIBITOR; DRUG; TOMM40; PROTEIN
AB Alzheimer disease (AD) and related forms of dementia are among the main medical and social problems in the economically developed countries. It is connected with significant increase in human life span in these regions and with the absence of efficient medicines for treatment and prevention of such diseases. Lack of positive results in the developing of novel drugs for AD treatment stimulates special attention on problem of early diagnosis and drug discovery for pharmacotherapy on the very early stages of dementia, in particular, on mild cognitive impairments (MCI) due to AD. Here we review the state of art in the field of MCI diagnostics and analyze the data on the pharmacological agents developed for MCI treatment, which currently are in preclinical and clinical trials. The conclusion was made that only the agents that act on the very early pathogenetic stages of the disease, when the damage of cholinergic neurons is not observed, can be efficient for pharmacotherapeutic intervention of MCI. Therefore, the focused search and design of "disease-modifying" medicines should be accepted as the most (and may be the only) efficient strategy for treatment and prevention of MCI. (C) 2017 Published by Elsevier Ltd.
C1 [Bachurin, Sergey O.; Samsonova, Anna; Aliev, Gjumrakch] Russian Acad Sci, Inst Physiologically Act Cpds, Chernogolovka 1142432, Moscow Region, Russia.
   [Gavrilova, Svetlana I.] Mental Hlth Res Ctr, 34Kashirskoyeshosse, Moscow 115522, Russia.
   [Barreto, George E.] Pontificia Univ Javeriana, Fac Ciencias, Dept Nutr & Bioquim, Bogota, Colombia.
   [Barreto, George E.] Univ Autonoma Chile, Inst Ciencias Biomed, Santiago, Chile.
   [Aliev, Gjumrakch] GALLY Int Biomed Res Consulting LLC, San Antonio, TX 78229 USA.
   [Aliev, Gjumrakch] Univ Atlanta, Sch Hlth Sci & Healthcare Adm, Johns Creek, GA 30097 USA.
C3 Russian Academy of Sciences; Institute of Physiologically Active
   Compounds of the Russian Academy of Sciences; Pontificia Universidad
   Javeriana; Universidad Autonoma de Chile
RP Bachurin, SO (corresponding author), Russian Acad Sci, Inst Physiologically Act Cpds, Severny Pr 1, Chernogolovka 142432, Russia.
EM aliev03@gmail.com
RI Barreto, George E./AAD-7420-2020; Sergey, Bachurin/I-1708-2018; Aliev,
   Gjumrakch/AAE-7734-2020; Gavrilova, Svetlana/B-4548-2016
OI Barreto, George E./0000-0002-6644-1971; Aliev,
   Gjumrakch/0000-0001-7373-3182; Gavrilova, Svetlana/0000-0001-6683-0240
FU Russian Science Foundation [17-23-00013] Funding Source: Russian Science
   Foundation
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NR 72
TC 46
Z9 53
U1 0
U2 31
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2018
VL 129
BP 216
EP 226
DI 10.1016/j.phrs.2017.11.021
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GA1UJ
UT WOS:000428102600022
PM 29170097
DA 2023-08-17
ER

PT J
AU Barton, K
   Johnson, I
   Mountford, A
AF Barton, Karen
   Johnson, Ian
   Mountford, Amy
TI Development of a psychosocial group intervention for individuals with
   mild cognitive impairment (innovative practice)
SO DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
LA English
DT Article
DE mild cognitive impairment; mild cognitive disorder; mild cognitive
   impairment; recovery model; group intervention
ID DEMENTIA
AB A diagnosis of mild cognitive impairment is associated with an increase in anxiety and depression and a decrease in psychological well-being. Despite this, individuals with mild cognitive impairment may not receive the appropriate support needed to manage the emotional and practical elements of their diagnosis. A psychosocial group intervention based on the 'Recovery Model' was developed in order to meet these needs. Outcome data from a trial of this group intervention indicated it was successful in meeting its aims.
C1 [Barton, Karen; Johnson, Ian; Mountford, Amy] Birmingham Solihull Mental Hlth Natl Hlth Serv Fd, Birmingham, W Midlands, England.
RP Johnson, I (corresponding author), Birmingham Solihull Mental Hlth Natl Hlth Serv Fd, Birmingham, W Midlands, England.
EM ian.m.joh@gmail.com
CR [Anonymous], WELL WHAT DO YOU THI
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NR 17
TC 2
Z9 2
U1 2
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1471-3012
EI 1741-2684
J9 DEMENTIA-LONDON
JI Dement.-Int. J. soc. Res. Pract.
PD MAY
PY 2020
VL 19
IS 4
BP 1325
EP 1332
DI 10.1177/1471301217741007
PG 8
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA LG3DJ
UT WOS:000527985400027
PM 29145738
DA 2023-08-17
ER

PT J
AU Gonzalez, PC
   Fong, KNK
   Chung, RCK
   Ting, KH
   Law, LLF
   Brown, T
AF Gonzalez, Pablo Cruz
   Fong, Kenneth N. K.
   Chung, Raymond C. K.
   Ting, Kin-Hung
   Law, Lawla L. F.
   Brown, Ted
TI Can Transcranial Direct-Current Stimulation Alone or Combined With
   Cognitive Training Be Used as a Clinical Intervention to Improve
   Cognitive Functioning in Persons With Mild Cognitive Impairment and
   Dementia? A Systematic Review and Meta-Analysis
SO FRONTIERS IN HUMAN NEUROSCIENCE
LA English
DT Review
DE tDCS (transcranial direct-current stimulation); neuromodulation; MCI
   (mild cognitive impairment); dementia; cognitive rehabilitation;
   cognitive training; systematic review; meta-analysis
ID NONINVASIVE BRAIN-STIMULATION; OF-THE-ART; ALZHEIMERS-DISEASE;
   ELECTRICAL-STIMULATION; MEMORY; TDCS; HIPPOCAMPUS; DIAGNOSIS; EFFICACY;
   CORTEX
AB Background: Transcranial direct-current stimulation (tDCS) facilitates cognitive improvement in healthy and pathological populations. It has been increasingly used in cases of mild cognitive impairment (MCI) and dementia. Our research question is: Can tDCS serve as a clinical intervention for improving the cognitive functions of persons with MCI (PwMCI) and dementia (PwD)?
   Objective: This systematic review evaluated the evidence to determine the efficacy of tDCS in improving cognitive outcomes in PwD and PwMCI.
   Methods: A systematic review was conducted of studies published up to November 2017 involving tDCS in cases of MCI and dementia. Studies were ranked according to the level of evidence (Oxford Center for Evidence-Based Medicine) and assessed for methodological quality (Risk of Bias Tool in the Cochrane Handbook for Systematic Reviews of Interventions). Data was extracted on all protocol variables to establish a reference framework for clinical interventions. Different modalities, tDCS alone or combined with cognitive training, compared with sham tDCS were examined in both short and long-term effects. Four randomized control trials (RCTs) with memory outcomes were pooled using the fixed-effect model for the meta-analysis.
   Results: Twelve studies with 195 PwD and four with 53 PwMCI met the inclusion criteria. Eleven articles were ranked as Level 1b. The results on the meta-analysis on pooled effects of memory indicated a statistically significant medium effect size of 0.39 (p = 0.04) for immediate effects. This improvement was not maintained in the long term 0.15 (p = 0.44).
   Conclusion: tDCS improves memory in PwD in the short term, it also seems to have a mild positive effect on memory and language in PwMCI. However, there is no conclusive advantage in coupling tDCS with cognitive training. More rigorous evidence is needed to establish whether tDCS can serve as an evidence-based intervention for both populations.
C1 [Gonzalez, Pablo Cruz; Fong, Kenneth N. K.; Chung, Raymond C. K.] Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.
   [Fong, Kenneth N. K.; Ting, Kin-Hung] Hong Kong Polytech Univ, Univ Res Facil Behav & Syst Neurosci, Kowloon, Hong Kong, Peoples R China.
   [Law, Lawla L. F.] Tung Wah Coll, Sch Med & Hlth Sci, Kowloon, Hong Kong, Peoples R China.
   [Brown, Ted] Monash Univ, Dept Occupat Therapy, Melbourne, Vic, Australia.
C3 Hong Kong Polytechnic University; Hong Kong Polytechnic University;
   Monash University
RP Fong, KNK (corresponding author), Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.; Fong, KNK (corresponding author), Hong Kong Polytech Univ, Univ Res Facil Behav & Syst Neurosci, Kowloon, Hong Kong, Peoples R China.
EM rsnkfong@polyu.edu.hk
RI Law, Lawla LF/ITT-3564-2023; Ting, Kin-Hung/A-2677-2017; Fong, Kenneth
   N. K./F-9608-2014
OI Ting, Kin-Hung/0000-0002-6071-3569; Cruz, Pablo/0000-0001-9073-3061;
   Fong, Kenneth N. K./0000-0001-5909-4847
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NR 46
TC 32
Z9 32
U1 2
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5161
J9 FRONT HUM NEUROSCI
JI Front. Hum. Neurosci.
PD OCT 16
PY 2018
VL 12
AR 416
DI 10.3389/fnhum.2018.00416
PG 14
WC Neurosciences; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychology
GA GX1AW
UT WOS:000447445400003
PM 30386223
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Xu, ZJ
   Zhang, DX
   Lee, ATC
   Sit, RWS
   Wong, C
   Lee, EKP
   Yip, BHK
   Tiu, JYS
   Lam, LCW
   Wong, SYS
AF Xu, Zijun
   Zhang, Dexing
   Lee, Allen T. C.
   Sit, Regina W. S.
   Wong, Carmen
   Lee, Eric K. P.
   Yip, Benjamin H. K.
   Tiu, Jennifer Y. S.
   Lam, Linda C. W.
   Wong, Samuel Y. S.
TI A pilot feasibility randomized controlled trial on combining mind-body
   physical exercise, cognitive training, and nurse-led risk factor
   modification to reduce cognitive decline among older adults with mild
   cognitive impairment in primary care
SO PEERJ
LA English
DT Article
DE Dementia prevention; Mild cognitive impairment; Primary care;
   Multi-component intervention
ID HONG-KONG; DEMENTIA; RELIABILITY; POPULATION; PREVENTION; VALIDITY;
   VERSION; TARGET; SCALE
AB Objectives. To examine the feasibility and preliminary effectiveness of (1) combining cognitive training, mind-body physical exercise, and nurse-led risk factor modification (CPR), (2) nurse-led risk factor modification (RFM), and (3) health advice (HA) on reducing cognitive decline among older adults with mild cognitive impairment (MCI).
   Methods. It was a 3-arm open-labeled pilot randomized controlled trial in the primary care setting in Hong Kong. Nineteen older adults with MCI were randomized to either CPR (n = 6), RFM (n = 7), or HA (n = 6) for 6 months. The primary outcome was the feasibility of the study. Secondary outcomes included the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), the Montreal Cognitive Assessment Hong Kong version (HK-MoCA), the Clinical Dementia Rating (CDR), the Disability Assessment for Dementia (DAD), quality of life, depression, anxiety, physical activity, health service utilization, and diet.
   Results. Nineteen out the 98 potential patients were recruited, with a recruitment rate of 19% (95% CI [12-29]%, P = 0.243). The adherence rate of risk factor modification was 89% (95% CI [65-98]%, P = 0.139) for CPR group and 86% (95% CI [63-96]%, P = 0.182) for RFM group. In the CPR group, 53% (95% CI [36-70]%, P = 0.038) of the Tai Chi exercise sessions and 54% (95% CI [37-71]%, P = 0.051) of cognitive sessions were completed. The overall dropout rate was 11% (95% CI [2-34]%, P = 0.456). Significant within group changes were observed in HK-MoCA in RFM (4.50 +/- 2.59, P = 0.008), cost of health service utilization in CPR (-4000, quartiles: -6800 to -200, P = 0.043), fish and seafood in HA (-1.10 +/- 1.02, P = 0.047), and sugar in HA (2.69 +/- 1.80, P = 0 .015) . Group x time interactions were noted on HK-MoCA favoring the RFM group (P = 0.000), DAD score favoring CPR group (P = 0.027), GAS-20 favoring CPR group (P = 0 .026) , number of servings of fish and seafood (P = 0 .004) , and sugar (P < 0.001) ate per day.
   Conclusions. In this pilot study, RFM and the multi-domain approach CPR were feasible and had preliminary beneficial effects in older adults with MCI in primary care setting in Hong Kong.
C1 [Xu, Zijun; Zhang, Dexing; Sit, Regina W. S.; Wong, Carmen; Lee, Eric K. P.; Yip, Benjamin H. K.; Tiu, Jennifer Y. S.; Wong, Samuel Y. S.] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Div Family Med & Primary Hlth Care, Hong Kong, Peoples R China.
   [Lee, Allen T. C.; Lam, Linda C. W.] Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong
RP Wong, SYS (corresponding author), Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Div Family Med & Primary Hlth Care, Hong Kong, Peoples R China.
EM yeungshanwong@cuhk.edu.hk
RI Lee, Allen/AEP-1064-2022; Lee, Kam Pui Eric/I-3685-2018; Yip,
   Benjamin/AAC-7845-2019
OI Lee, Kam Pui Eric/0000-0001-8267-9384; Yip,
   Benjamin/0000-0002-4749-7611; Lee, Allen/0000-0003-4196-5442
FU Hong Kong Jockey Club Charities Trust
FX The nurses who worked on this pilot project are supported by The Hong
   Kong Jockey Club Charities Trust. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 34
TC 11
Z9 12
U1 8
U2 34
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD SEP 7
PY 2020
VL 8
AR e9845
DI 10.7717/peerj.9845
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA NK3VF
UT WOS:000566661300003
PM 33194354
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Farhang, M
   Miranda-Castillo, C
   Rubio, M
   Furtado, G
AF Farhang, Maryam
   Miranda-Castillo, Claudia
   Rubio, Miriam
   Furtado, Guilherme
TI Impact of mind-body interventions in older adults with mild cognitive
   impairment: a systematic review
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Review
DE mind-body intervention; mild cognitive impairment; mindfulness; aging
ID MINDFULNESS-BASED INTERVENTIONS; RANDOMIZED CONTROLLED-TRIAL; TAI-CHI
   EXERCISE; DEPRESSIVE SYMPTOMS; ALZHEIMERS-DISEASE; PHYSICAL-EXERCISE;
   YOGA INTERVENTION; MEMORY; MEDITATION; DEMENTIA
AB Background: Mind-body interventions have been associated with a range of positive outcomes in older adults with mild cognitive impairment (MCI). The aim of the present study was to review the impact of different non-pharmacological programs based on mind-body intervention for older adults with MCI. Methods: A comprehensive search method as required by the Cochrane Collaboration has been performed through the following databases: Google Scholar, Science Direct, PubMed, PsycINFO, MEDLINE, EMBASE, CINHAL, Cochrane, Ebsco. We included the studies that evaluated the impact of mind-body interventions such as mindfulness or meditation, yoga, Tai Chi and Qigong on cognitive function and everyday functionality of non-hospitalized adults aged 55 years or over with MCI. Results: Nine studies met the inclusion criteria. Results indicated that mind-body interventions improved cognitive function, everyday activities functioning, and mindfulness, as well as resulting in a moderate reduction in fall risk, depression and stress and lower risk of dementia at one year. Conclusion: Several mind-body interventions focused broadly on mindfulness, yoga and Tai Chi training have been studied. This review shows that mind-body interventions improved cognitive function and everyday activities functioning, memory, resilience and mindfulness in older adults with MCI. However, the conclusions faced limitations, such as small sample size, heterogeneity of outcome measures, lack of an active control group and absence of long-term follow up. Further high-quality evidence is needed in order to determine whether mind-body interventions are cost-effective for improving cognitive decline in older adults with MCI and for delaying the rapid progression from MCI to Alzheimer or other types of dementia.
C1 [Farhang, Maryam; Miranda-Castillo, Claudia] Pontificia Univ Catolica Chile, Millennium Inst Res Depress & Personal MIDAP, Avda Vicuna Mackenna 4860, Santiago, Chile.
   [Rubio, Miriam] Pontificia Univ Catolica Chile, Sch Nursing, Santiago, Chile.
   [Furtado, Guilherme] Univ Coimbra, Fac Sport Sci & Phys Educ, Ctr Res Unit Sport & Phys Act CIDAF, Coimbra, Portugal.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; Universidade de Coimbra
RP Farhang, M (corresponding author), Pontificia Univ Catolica Chile, Millennium Inst Res Depress & Personal MIDAP, Avda Vicuna Mackenna 4860, Santiago, Chile.
EM Maryam.farhang@uc.cl
RI Furtado, Guilherme/AAR-1200-2020; Castillo, Claudia Miranda/F-5360-2013
OI Furtado, Guilherme/0000-0001-8327-1567; Miranda-Castillo,
   Claudia/0000-0002-0282-5845; farhang, maryam/0000-0001-6345-6329
FU Fund for Innovation and Competitiveness (FIC) of the Chilean Ministry of
   Economy, Development and Tourism, through the Millennium Scientific
   Initiative [IS130005-MIDAP]; National Fund for Scientific and
   Technological Development (FONDECYT) [1141279, 11100457]; CAPES/CNPQ -
   Ministry of Education - Brazil [BEX: 11929/13-8]
FX This research was supported by the Fund for Innovation and
   Competitiveness (FIC) of the Chilean Ministry of Economy, Development
   and Tourism, through the Millennium Scientific Initiative [Grant number
   IS130005-MIDAP] and the National Fund for Scientific and Technological
   Development (FONDECYT) Project No 1141279 and 11100457. Guilherme
   Furtado was financed by a grant from CAPES/CNPQ - Ministry of Education
   - Brazil, reference BEX: 11929/13-8.
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NR 80
TC 53
Z9 55
U1 5
U2 49
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD MAY
PY 2019
VL 31
IS 5
SI SI
BP 643
EP 666
AR PII S1041610218002302
DI 10.1017/S1041610218002302
PG 24
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA IE2ER
UT WOS:000472197800005
PM 30712518
DA 2023-08-17
ER

PT J
AU Laffer, A
   Breda, A
   Bevan, A
   Gardiner, P
   Watts, A
AF Laffer, Alexandra
   Breda, Aili
   Bevan, Andrea
   Gardiner, Paul
   Watts, Amber
TI FEASIBILITY OF AN INTERVENTION TO REDUCE SEDENTARY TIME IN OLDER ADULTS
   WITH MILD COGNITIVE IMPAIRMENT
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Meeting Abstract
C1 [Laffer, Alexandra; Breda, Aili; Bevan, Andrea; Watts, Amber] Univ Kansas, Lawrence, KS 66045 USA.
   [Gardiner, Paul] Univ Queensland, Woolloongabba, Qld, Australia.
C3 University of Kansas; University of Queensland
EM alex.laffer@ku.edu
RI Watts, Amber/AAL-5754-2020
OI Watts, Amber/0000-0002-8385-1091
NR 0
TC 0
Z9 0
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD MAR
PY 2019
VL 53
SU 1
MA D309
BP S803
EP S803
PG 1
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IF8NR
UT WOS:000473349401829
DA 2023-08-17
ER

PT J
AU Ishizaki, J
   Meguro, K
   Ishii, H
   Yamaguchi, S
   Shimada, M
   Yamadori, A
   Ohe, K
   Tsuchiya, E
   Kimura, E
   Meguro, M
   Sekita, Y
AF Ishizaki, J
   Meguro, K
   Ishii, H
   Yamaguchi, S
   Shimada, M
   Yamadori, A
   Ohe, K
   Tsuchiya, E
   Kimura, E
   Meguro, M
   Sekita, Y
TI Therapeutic psychosocial intervention for mild cognitive impairment
   subjects in a community: Tajiri-MCI project (6)
SO NEUROBIOLOGY OF AGING
LA English
DT Meeting Abstract
C1 Tohoku Univ, Dept Dis Med, Div Neuropsychol, Sendai, Miyagi 980, Japan.
   Tajiri SKIP Ctr, Tajiri, Japan.
   Tohoku Univ, Grad Sch Econ, Div Hlth Care Sys Sci, Sendai, Miyagi 980, Japan.
C3 Tohoku University; Tohoku University
CR Ishizaki J, 2000, INT J GERIATR PSYCH, V15, P532, DOI 10.1002/1099-1166(200006)15:6<532::AID-GPS144>3.0.CO;2-9
   MEGURO, 2001, J GERONTOL PSYCHOL B, V56, P314
NR 2
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD JUL-AUG
PY 2002
VL 23
IS 1
SU 1
MA 1973
BP S539
EP S539
PG 1
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 584KG
UT WOS:000177465301936
DA 2023-08-17
ER

PT J
AU Greenaway, MC
   Duncan, NL
   Smith, GE
AF Greenaway, M. C.
   Duncan, N. L.
   Smith, G. E.
TI The memory support system for mild cognitive impairment: randomized
   trial of a cognitive rehabilitation intervention
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE mild cognitive impairment; rehabilitation; behavioral intervention;
   activities of daily living; quality of life; caregivers
ID OLDER-ADULTS; DISEASE; LIFE
AB Objective Individuals with amnestic mild cognitive impairment (MCI) have few empirically based treatment options for combating their memory loss. This study sought to examine the efficacy of a calendar/notebook rehabilitation intervention, the memory support system (MSS), for individuals with amnestic MCI. Methods Forty individuals with single domain amnestic MCI and their program partners were randomized to receive the MSS, either with training or without (controls). Measures of adherence, activities of daily living, and emotional impact were completed at the first and last intervention sessions and again at 8weeks and 6months post intervention. Results Training in use of a notebook/calendar system significantly improved adherence over those who received the calendars but no training. Functional ability and memory self-efficacy significantly improved for those who received MSS training. Change in functional ability remained significantly better in the intervention group than in the control group out to 8-week follow-up. Care partners in the intervention group demonstrated improved mood by 8-week and 6-month follow-ups, whereas control care partners reported worse caregiver burden by 6-month follow-up. Conclusions Memory support system training resulted in improvement in activities of daily living and sense of memory self-efficacy for individuals with MCI. Although activities of daily living benefits were maintained out to 8weeks post intervention, future inclusion of booster sessions may help extend the therapeutic effect out even further. Improved mood of care partners of trained individuals and worsening sense of caregiver burden over time for partners of untrained individuals further support the efficacy of the MSS for MCI. Copyright (c) 2012 John Wiley & Sons, Ltd.
C1 [Greenaway, M. C.; Duncan, N. L.] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA.
   [Smith, G. E.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
C3 Emory University; Mayo Clinic
RP Greenaway, MC (corresponding author), Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA.
EM mcgree3@emory.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Smith,
   Glenn/0000-0003-1506-9484
FU Alzheimer's Association [NIRG-07-58843]; Emory Alzheimer's Disease
   Research Center [AG025688]
FX This project was funded in part by the Alzheimer's Association,
   NIRG-07-58843 and the Emory Alzheimer's Disease Research Center,
   AG025688.
CR [Anonymous], COCHRANE DATABASE SY
   [Anonymous], 1990, MEMORY BEHAV PROBLEM
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NR 27
TC 104
Z9 109
U1 1
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD APR
PY 2013
VL 28
IS 4
BP 402
EP 409
DI 10.1002/gps.3838
PG 8
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 103ZR
UT WOS:000315958800010
PM 22678947
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Bao, WR
   Qu, Y
   Gong, GM
   Zhang, JF
AF Bao, Wuren
   Qu, Ying
   Gong, Guomei
   Zhang, Jifeng
TI Study on risk prediction and intervention coping of mild cognitive
   impairment in patients with hypertension
SO CNS SPECTRUMS
LA English
DT Meeting Abstract
C1 [Bao, Wuren; Qu, Ying] Inner Mongolia Minzu Univ, Tongliao 028000, Peoples R China.
   [Gong, Guomei] Quanzhou Med Coll, Quanzhou 362000, Peoples R China.
   [Zhang, Jifeng] Tongliao City Hosp, Tongliao 028000, Peoples R China.
FU Study of the Effect of Health Education Based on Teach-back and PRECEDE
   Model on Elderly Hypertensive Patients in the Community - Fundamental
   Research Funds for Universities of Inner Mongolia Autonomous Region;
   Construction of Human Care Training Courses for Nursing Students Based
   on Health Care of Elderly Patients with Chronic Diseases - Higher
   Education Teaching Reform Project of National Ethnic Affairs Commission,
   2021 [21083]; An Exploration of the Ideological and Political
   Construction in Human Care Training Courses of Higher Education for
   Nursing Students in the New Era - Education and Science Project of Inner
   Mongolia Autonomous Region during the 14th FiveYear Plan Period, 20
   [NGJGH2021145]
FX The research is supported by: The Study of the Effect of Health
   Education Based on Teach-back and PRECEDE Model on Elderly Hypertensive
   Patients in the Community, supported by Fundamental Research Funds for
   Universities of Inner Mongolia Autonomous Region; The Construction of
   Human Care Training Courses for Nursing Students Based on Health Care of
   Elderly Patients with Chronic Diseases, supported by Higher Education
   Teaching Reform Project of National Ethnic Affairs Commission, 2021
   (No.21083); An Exploration of the Ideological and Political Construction
   in Human Care Training Courses of Higher Education for Nursing Students
   in the New Era, supported by a grant from the Education and Science
   Project of Inner Mongolia Autonomous Region during the 14th FiveYear
   Plan Period, 2021 (No.NGJGH2021145).
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD MAR
PY 2023
VL 28
SU 1
BP S20
EP S21
PG 2
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA L4GO4
UT WOS:001022860700001
DA 2023-08-17
ER

PT J
AU Montgomery, V
   Harris, K
   Murphy, J
   Stabler, A
   Clingerman, S
AF Montgomery, V.
   Harris, K.
   Murphy, J.
   Stabler, A.
   Clingerman, S.
TI Revisiting early screenings as a preventive intervention in patients at
   risk for mild cognitive impairment
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
U1 0
U2 2
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PY 2016
VL 30
IS 3
MA 26 S
BP 385
EP 385
PG 1
WC Psychology, Clinical; Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA DL2NJ
UT WOS:000375471800027
DA 2023-08-17
ER

PT J
AU Sherman, DS
   Mauser, J
   Nuno, M
   Sherzai, D
AF Sherman, Dale S.
   Mauser, Justin
   Nuno, Miriam
   Sherzai, Dean
TI The Efficacy of Cognitive Intervention in Mild Cognitive Impairment
   (MCI): a Meta-Analysis of Outcomes on Neuropsychological Measures
SO NEUROPSYCHOLOGY REVIEW
LA English
DT Review
DE Mild cognitive impairment (MCI): Cognitive interventions; Cognitive
   training; Cognitive strategies; Cognitive rehabilitation; Treatment
   efficacy; Neuropsychological outcomes; Meta-analysis
ID HEALTHY OLDER-ADULTS; ALZHEIMERS-DISEASE; FOCUSED INTERVENTIONS;
   LIFE-STYLE; MEMORY ENHANCEMENT; BRAIN PLASTICITY; WORKING-MEMORY;
   REHABILITATION; STIMULATION; INDIVIDUALS
AB Cognitive training in MCI may stimulate pre-existing neural reserves or recruit neural circuitry as "compensatory scaffolding" prompting neuroplastic reorganization to meet task demands (Reuter-Lorenz & Park, 2014). However, existing systematic reviews and meta-analytic studies exploring the benefits of cognitive interventions in MCI have been mixed. An updated examination regarding the efficacy of cognitive intervention in MCI is needed given improvements in adherence to MCI diagnostic criteria in subject selection, better defined interventions and strategies applied, increased use of neuropsychological measures pre- and post-intervention, as well as identification of moderator variables which may influence treatment. As such, this meta-analytic review was conducted to examine the efficacy of cognitive intervention in individuals diagnosed with mild cognitive impairment (MCI) versus MCI controls based on performance of neuropsychological outcome measures in randomized controlled trials (RCT). RCT studies published from January 1995 to June 2017 were obtained through source databases of MEDLINE-R, PubMed, Healthstar, Global Health, PSYCH-INFO, and Health and Psychological Instruments using search parameters for MCI diagnostic category (mild cognitive impairment, MCI, pre-Alzheimer's disease, early cognitive decline, early onset Alzheimer's disease, and preclinical Alzheimer's disease) and the intervention or training conducted (intervention, training, stimulation, rehabilitation, or treatment). Other inclusion and exclusion criteria included subject selection based on established MCI criteria, RCT design in an outpatient setting, MCI controls (active or passive), and outcomes based on objective neuropsychological measures. From the 1199 abstracts identified, 26 articles met inclusion criteria for the meta-analyses completed across eleven (11) countries; 92.31% of which have been published within the past 7 years. A series of meta-analyses were performed to examine the effects of cognitive intervention by cognitive domain, type of training, and intervention content (cognitive domain targeted). We found significant, moderate effects for multicomponent training (Hedges' g observed = 0.398; CI [0.164, 0.631]; Z = 3.337; p = 0.001; Q = 55.511; df = 15; p = 0.000; I (2) = 72.978%; tau (2) = 0.146) as well as multidomain-focused strategies (Hedges' g = 0.230; 95% CI [0.108, 0.352]; Z = 3.692; p < 0.001; Q = 12.713; df = 12; p = 0.390; I (2) = 5.612; tau (2) = 0.003). The effects for other interventions explored by cognitive domain, training type, or intervention content were indeterminate due to concerns for heterogeneity, bias, and small cell sizes. In addition, subgroup and meta-regression analyses were conducted with the moderators of MCI category, mode of intervention, training type, intervention content, program duration (total hours), type of control group (active or passive), post-intervention follow-up assessment period, and control for repeat administration. We found significant overall effects for intervention content with memory focused interventions appearing to be more effective than multidomain approaches. There was no evidence of an influence on outcomes for the other covariates examined. Overall, these findings suggest individuals with MCI who received multicomponent training or interventions targeting multiple domains (including lifestyle changes) were apt to display an improvement on outcome measures of cognition post-intervention.
   As such, multicomponent and multidomain forms of intervention may prompt recruitment of alternate neural processes as well as support primary networks to meet task demands simultaneously. In addition, interventions with memory and multidomain forms of content appear to be particularly helpful, with memory-based approaches possibly being more effective than multidomain methods. Other factors, such as program duration, appear to have less of an influence on intervention outcomes. Given this, although the creation of new primary network paths appears strained in MCI, interventions with memory-based or multidomain forms of content may facilitate partial activation of compensatory scaffolding and neuroplastic reorganization. The positive benefit of memory-based strategies may also reflect transfer effects indicative of compensatory network activation and the multiple-pathways involved in memory processes. Limitations of this review are similar to other meta-analysis in MCI, including a modest number studies, small sample sizes, multiple forms of interventions and types of training applied (some overlapping), and, while greatly improved in our view, a large diversity of instruments used to measure outcome. This is apt to have contributed to the presence of heterogeneity and publication bias precluding a more definitive determination of the outcomes observed.
C1 [Sherman, Dale S.] Cedars Sinai Med Ctr, 444 S San Vicente Blvd,Suite 103, Los Angeles, CA 90048 USA.
   [Sherman, Dale S.] Univ Southern Calif, Los Angeles, CA 90007 USA.
   [Mauser, Justin] Virginia Commonwealth Univ, Sch Med, Richmond, VA USA.
   [Nuno, Miriam] Univ Calif Davis, Davis, CA 95616 USA.
   [Sherzai, Dean] Loma Linda Univ Hlth, 11370 Anderson St B100, Loma Linda, CA 92354 USA.
C3 Cedars Sinai Medical Center; University of Southern California; Virginia
   Commonwealth University; University of California System; University of
   California Davis; Loma Linda University
RP Sherman, DS (corresponding author), Cedars Sinai Med Ctr, 444 S San Vicente Blvd,Suite 103, Los Angeles, CA 90048 USA.; Sherman, DS (corresponding author), Univ Southern Calif, Los Angeles, CA 90007 USA.
EM dale.sherman@cshs.org; mauserja@vcu.edu; mnuno@ucdavis.edu;
   dsherzai@llu.edu
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NR 137
TC 117
Z9 129
U1 9
U2 64
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1040-7308
EI 1573-6660
J9 NEUROPSYCHOL REV
JI Neuropsychol. Rev.
PD DEC
PY 2017
VL 27
IS 4
SI SI
BP 440
EP 484
DI 10.1007/s11065-017-9363-3
PG 45
WC Psychology, Clinical; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA FS0QF
UT WOS:000419478100008
PM 29282641
OA Green Published, hybrid
DA 2023-08-17
ER

PT J
AU Tremont, G
   Davis, J
   Ott, BR
   Uebelacker, L
   Kenney, L
   Gillette, T
   Britton, K
   Sanborn, V
AF Tremont, Geoffrey
   Davis, Jennifer
   Ott, Brian R.
   Uebelacker, Lisa
   Kenney, Lauren
   Gillette, Tom
   Britton, Karysa
   Sanborn, Victoria
TI Feasibility of a Yoga Intervention for Individuals with Mild Cognitive
   Impairment: A Randomized Controlled Trial
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE yoga; mild cognitive impairment; feasibility
ID ALZHEIMERS-DISEASE; SHORT-FORM; STRESS; VALIDATION
AB Background: Yoga is a potentially low risk intervention for cognitive impairment that combines mental and physical practice and includes instruction on breathing, stress reduction, and mindfulness meditation. Previous research documents that yoga can target modifiable risk factors for mild cognitive impairment (MCI) progression. The authors describe a randomized feasibility trial of yoga for individuals with MCI.Methods: Participants were 37 individuals with amnestic MCI who were randomly assigned to receive 12 weeks of twice-weekly yoga intervention (YI) or healthy living education (HLE) classes. Acceptability and feasibility were assessed by tracking adverse events, class attendance, and participant satisfaction. Participants completed neuropsychological and mood measures as well as measures of potential intervention mechanisms at baseline and immediately postintervention.Results: Participants in both conditions reported high levels of satisfaction and reasonable class attendance rates. Home practice rates were low. There were no adverse events deemed related to the YI. Results showed a medium effect size in favor of the YI in visuospatial skills. The yoga group also showed a large effect size indicating decline in perceived stress compared with the HLE group, whereas HLE resulted in greater reductions in depressive symptoms after the intervention (large effect size).Conclusions: Study findings indicated that the YI was safe, modestly feasible, and acceptable to older adults with MCI. The authors found preliminary evidence that yoga may improve visuospatial functioning in individuals with MCI. Results support stress reduction as a possible mechanism for the YI. Future studies should address a YI in a larger sample and include strategies to enhance engagement and home practice.
C1 [Tremont, Geoffrey; Davis, Jennifer; Ott, Brian R.; Kenney, Lauren; Britton, Karysa; Sanborn, Victoria] Rhode Isl Hosp, Dept Psychiat, Providence, RI USA.
   [Tremont, Geoffrey; Davis, Jennifer; Uebelacker, Lisa] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI USA.
   [Ott, Brian R.] Brown Univ, Warren Alpert Med Sch, Dept Neurol, Providence, RI USA.
   [Uebelacker, Lisa] Butler Hosp, Providence, RI USA.
   [Gillette, Tom] Eyes World Yoga Ctr, Providence, RI USA.
   [Tremont, Geoffrey] Rhode Isl Hosp, Dept Psychiat, 593 Eddy St, Providence, RI 02903 USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Brown University; Butler Hospital Rhode Island; Lifespan Health Rhode
   Island; Rhode Island Hospital
RP Tremont, G (corresponding author), Rhode Isl Hosp, Dept Psychiat, 593 Eddy St, Providence, RI 02903 USA.
EM gtremont@lifespan.org
OI Tremont, Geoffrey/0000-0002-1506-0722
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NR 54
TC 3
Z9 3
U1 8
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD MAR 1
PY 2022
VL 28
IS 3
BP 250
EP 260
DI 10.1089/jicm.2021.0204
EA JAN 2022
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 8M4QR
UT WOS:000844452500001
PM 35294301
DA 2023-08-17
ER

PT J
AU Yang, QH
   Lyu, X
   Lin, QR
   Wang, ZW
   Tang, L
   Zhao, Y
   Lyu, QY
AF Yang, Qiao-hong
   Lyu, Xia
   Lin, Qing-ran
   Wang, Zi-wen
   Tang, Li
   Zhao, Yu
   Lyu, Qi-yuan
TI Effects of a multicomponent intervention to slow mild cognitive
   impairment progression: A randomized controlled trial
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Cognitive function; Dementia; Depression; Elderly; Mild cognitive
   impairment; Patients; Physical function
ID SCALE GDS-15; OLDER-ADULTS; DEMENTIA; SAMPLE; RISK; INDIVIDUALS;
   EXERCISE; QUALITY; LIFE
AB Background: Mild cognitive impairment affects 36% of people aged >65 years in China, around 50% of whom will develop dementia within 3 years. Early intervention can slow disease progression and delay the onset of dementia; however, whether a multicomponent intervention can decelerate the progression of mild cognitive impairment remains unknown. Objective: To evaluate the effects of a multicomponent intervention to slow mild cognitive impairment progression in Chinese patients. Design: Randomized controlled trial. Setting(s) and participants: This study was conducted in two large regional communities in Guangzhou, China. Patients aged > 65 years diagnosed with mild cognitive impairment were included. Methods: A total of 112 eligible participants were assigned to receive either a 6-month multicomponent intervention or usual care from September 2019 until January 2021. Data were collected at the beginning of the study and at 1, 3, and 6 months thereafter. The primary outcomes were cognitive function, comprehensive physical capacity, depression, and quality of life. Analysis followed the intention-to-treat principle. A generalized estimating equation was used to determine intervention effects. Results: At baseline, clinical characteristics did not differ significantly between groups. Significant interaction effects between time and group were detected ( p < 0.001), indicating that the scores of five outcomes (cognitive function, short physical performance battery, timed up and go test, quality of life, and depression) of intervention and control groups changed differently over time. Participants in the intervention group were found to have a significantly greater improvement in cognitive function, physical function, quality of life, and fewer depression symptoms compared with the control group at baseline and follow-up periods. Conclusions: This study demonstrates the beneficial effects of a multicomponent intervention on cognitive function, physical function, depression symptoms, and quality of life in people with mild cognitive impairment in the East Asia region. The effectiveness and feasibility of this intervention program suggest that its application should be promoted in community settings to delay the progression of disease in people with mild cognitive impairment. Registration number: ChiCTR190 0 026042 Tweetable abstract: The multicomponent intervention improves cognitive/physical function, depression, and quality of life, slowing cognitive impairment progression. (c) 2021 Elsevier Ltd. All rights reserved.
C1 [Yang, Qiao-hong; Wang, Zi-wen; Tang, Li; Zhao, Yu; Lyu, Qi-yuan] Jinan Univ, Sch Nursing, Guangzhou, Peoples R China.
   [Lin, Qing-ran] Jinan Univ, Nursing Dept, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Lyu, Xia] Shenzhen Peoples Hosp, Nursing Dept, Shenzhen, Peoples R China.
C3 Jinan University; Jinan University; Jinan University
RP Lyu, QY (corresponding author), Jinan Univ, Sch Nursing, Guangzhou, Peoples R China.
EM yuanqlv@163.com
FU National Natural Science Foundation of China [71804204]; Natural Science
   Foundation of Guangdong Province of China [2019A1515011672]; Ministry of
   Education Humanities and Social Sciences Research Youth Foundation
   [18YJCZH122]
FX Funding sources This study was funded by the National Natural Science
   Foundation of China (71804204) , the Natural Science Foundation of
   Guangdong Province of China (2019A1515011672) , and the Ministry of
   Education Humanities and Social Sciences Research Youth Foundation
   (18YJCZH122) .
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD JAN
PY 2022
VL 125
AR 104110
DI 10.1016/j.ijnurstu.2021.104110
EA OCT 2021
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA WX1DX
UT WOS:000718345300001
PM 34736073
DA 2023-08-17
ER

PT J
AU Dominguez-Chavez, CJ
   Murrock, CJ
   Guerrero, PIC
   Salazar-Gonzalez, BC
AF Jennifer Dominguez-Chavez, Claudia
   Murrock, Carolyn J.
   Cavazos Guerrero, Patricia I.
   Cecilia Salazar-Gonzalez, Bertha
TI Music therapy intervention in community-dwelling older adults with mild
   cognitive impairment: A pilot study
SO GERIATRIC NURSING
LA English
DT Article
DE Music therapy; Older adults; Mild cognitive impairment; Gait
ID GAIT VARIABILITY; DEMENTIA; DEPRESSION; MOVEMENT; PEOPLE; HEALTH; BRAIN;
   CONVERSION; RISK; QUESTIONNAIRE
AB The purpose of the pilot study was twofold, seeking to investigate both the feasibility and preliminary effects of a music therapy intervention on the global cognitive state (attention, immediate and delayed memory, and executive function) and gait parameters (gait velocity, cadence, and right and left stride length) in older adults with mild cognitive impairment (MCI). Sixteen participants attended the one-hour music therapy sessions three times a week for 12 weeks. The intervention was feasible, achieving a retention rate of 84%. Significant effects were found in global cognitive state (p = .001), attention (p = .007), immediate memory (p < .001), delayed memory (p = .001), executive function (p = .002), gait velocity (p = .021), right stride length (p = .007), and left stride length (p = .014). These results suggest that music therapy intervention is a potentially innovative strategy for improving cognition and gait parameters in older adults with MCI. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Jennifer Dominguez-Chavez, Claudia; Cecilia Salazar-Gonzalez, Bertha] Univ Autanoma Nuevo Leon, Fac Enfermeria, Mitras Ctr, Dr Jose Eleuterio Gonzalez 1500 St, Monterrey 64460, Nuevo Leon, Mexico.
   [Murrock, Carolyn J.] Univ Akron, Sch Nursing, 209 Carroll St, Akron, OH 44325 USA.
   [Cavazos Guerrero, Patricia I.] Univ Autonoma Nuevo Leon, Fac Mus, Unidad Mederos, Monterrey 64980, Nuevo Leon, Mexico.
C3 University System of Ohio; University of Akron; Universidad Autonoma de
   Nuevo Leon
RP Dominguez-Chavez, CJ (corresponding author), Univ Autanoma Nuevo Leon, Fac Enfermeria, Mitras Ctr, Dr Jose Eleuterio Gonzalez 1500 St, Monterrey 64460, Nuevo Leon, Mexico.
EM cjennifer_dguez23@hotmail.com
RI Domínguez-Chávez, Claudia Jennifer/ADG-6301-2022
OI Dominguez-Chavez, Claudia Jennifer/0000-0001-6230-8308;
   Salazar-Gonzalez, Bertha Cecilia/0000-0002-6610-8052
FU Consejo Nacional de Ciencia y Tecnologia de Mexico, National
   Postgraduate Program [328670]
FX This study was funded by Consejo Nacional de Ciencia y Tecnologia de
   Mexico, National Postgraduate Program (Scholarship number 328670, years
   2016-2019).
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NR 61
TC 11
Z9 13
U1 6
U2 47
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4572
EI 1528-3984
J9 GERIATR NURS
JI Geriatr. Nurs.
PD NOV-DEC
PY 2019
VL 40
IS 6
BP 614
EP 619
DI 10.1016/j.gerinurse.2019.06.004
PG 6
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA JZ4XH
UT WOS:000505105600011
PM 31277962
DA 2023-08-17
ER

PT J
AU Levine, H
   Randhawa, P
   Park, J
   Hung, LL
AF Levine, Hannah
   Randhawa, Paavan
   Park, JuYoung
   Hung, Lillian
TI TECHNOLOGY AND GROUP EXERCISE INTERVENTIONS FOR PEOPLE WITH DEMENTIA OR
   MILD COGNITIVE IMPAIRMENT: A SCOPING REVIEW
SO INNOVATION IN AGING
LA English
DT Meeting Abstract
C1 [Levine, Hannah] Florida Atlantic Univ, Charles E Schmidt Coll Med, Boca Raton, FL USA.
   [Randhawa, Paavan] Langara Coll, Vancouver, BC, Canada.
   [Park, JuYoung] Florida Atlantic Univ, Coll Social Work & Criminal Justice, Boca Raton, FL USA.
   [Hung, Lillian] Univ British Columbia, Vancouver, BC, Canada.
C3 State University System of Florida; Florida Atlantic University; State
   University System of Florida; Florida Atlantic University; University of
   British Columbia
RI Park, Juyoung/F-7065-2014
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2399-5300
J9 INNOV AGING
JI Innov. Aging
PD NOV
PY 2022
VL 6
SU 1
BP 68
EP 68
PG 1
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 7V8DU
UT WOS:000913044000264
DA 2023-08-17
ER

PT J
AU Dwolatzky, T
   Feuerstein, RS
   Manor, D
   Cohen, S
   Devisheim, H
   Inspector, M
   Eran, A
   Tzuriel, D
AF Dwolatzky, Tzvi
   Feuerstein, Refael S.
   Manor, David
   Cohen, Shlomit
   Devisheim, Haim
   Inspector, Michael
   Eran, Ayelet
   Tzuriel, David
TI Changes in Brain Volume Resulting from Cognitive Intervention by Means
   of the Feuerstein Instrumental Enrichment Program in Older Adults with
   Mild Cognitive Impairment (MCI): A Pilot Study
SO BRAIN SCIENCES
LA English
DT Article
DE brain morphometry; magnetic resonance imaging; cognition; mild cognitive
   impairment; Feuerstein Instrumental Enrichment; structural cognitive
   modifiability; mediated learning experience
ID FUNCTIONAL CONNECTIVITY; DEMENTIA; MATTER; MEMORY; STIMULATION;
   CONSENSUS; NETWORKS; MOCA
AB There is increasing interest in identifying biological and imaging markers for the early detection of neurocognitive decline. In addition, non-pharmacological strategies, including physical exercise and cognitive interventions, may be beneficial for those developing cognitive impairment. The Feuerstein Instrumental Enrichment (FIE) Program is a cognitive intervention based on structural cognitive modifiability and the mediated learning experience (MLE) and aims to promote problem-solving strategies and metacognitive abilities. The FIE program uses a variety of instruments to enhance the cognitive capacity of the individual as a result of mediation. A specific version of the FIE program was developed for the cognitive enhancement of older adults, focusing on strengthening orientation skills, categorization skills, deductive reasoning, and memory. We performed a prospective interventional pilot observational study on older subjects with MCI who participated in 30 mediated FIE sessions (two sessions weekly for 15 weeks). Of the 23 subjects who completed the study, there was a significant improvement in memory on the NeuroTrax cognitive assessment battery. Complete sets of anatomical MRI data for voxel-based morphometry, taken at the beginning and the end of the study, were obtained from 16 participants (mean age 83.5 years). Voxel-based morphometry showed an interesting and unexpected increase in grey matter (GM) in the anterolateral occipital border and the middle cingulate cortex. These initial findings of our pilot study support the design of randomized trials to evaluate the effect of cognitive training using the FIE program on brain volumes and cognitive function.
C1 [Dwolatzky, Tzvi; Manor, David; Inspector, Michael; Eran, Ayelet] Rambam Hlth Care Campus, IL-3525433 Haifa, Israel.
   [Dwolatzky, Tzvi] Ruth & Bruce Rappaport Fac Med, Techn Israel Inst Technol, IL-3109601 Haifa, Israel.
   [Feuerstein, Refael S.; Cohen, Shlomit; Devisheim, Haim; Tzuriel, David] Feuerstein Inst, IL-91077 Jerusalem, Israel.
   [Manor, David] Univ Haifa, Fac Life Sci, IL-3498838 Haifa, Israel.
   [Tzuriel, David] Bar Ilan Univ, Sch Educ, IL-5290002 Ramat Gan, Israel.
C3 Rambam Health Care Campus; Technion Israel Institute of Technology;
   Rappaport Faculty of Medicine; University of Haifa; Bar Ilan University
RP Dwolatzky, T (corresponding author), Rambam Hlth Care Campus, IL-3525433 Haifa, Israel.; Dwolatzky, T (corresponding author), Ruth & Bruce Rappaport Fac Med, Techn Israel Inst Technol, IL-3109601 Haifa, Israel.
EM tzvidov@gmail.com; Rafifu@icelp.org.il; da_manor@rambam.health.gov.il;
   cohensb@gmail.com; haimd@icelp.org.il; minspector212@gmail.com;
   a_eran@rambam.health.gov.il; David.tzuriel@biu.ac.il
RI Dwolatzky, Tzvi/P-4752-2019; Tzuriel, David/I-2961-2017
OI Dwolatzky, Tzvi/0000-0002-3861-2278; Tzuriel, David/0000-0003-4291-4495;
   Eran, Ayelet/0000-0003-1439-7881
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NR 54
TC 1
Z9 1
U1 6
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD DEC
PY 2021
VL 11
IS 12
AR 1637
DI 10.3390/brainsci11121637
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA XW4LN
UT WOS:000735592900001
PM 34942939
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Sale, A
   Noale, M
   Cintoli, S
   Tognoni, G
   Braschi, C
   Berardi, N
   Maggi, S
   Maffei, L
AF Sale, Alessandro
   Noale, Marianna
   Cintoli, Simona
   Tognoni, Gloria
   Braschi, Chiara
   Berardi, Nicoletta
   Maggi, Stefania
   Maffei, Lamberto
CA Train Brain Consortium
TI Long-term beneficial impact of the randomised trial 'Train the Brain', a
   motor/cognitive intervention in mild cognitive impairment people:
   effects at the 14-month follow-up
SO AGE AND AGEING
LA English
DT Article
DE mild cognitive impairment; cognitive rehabilitation; memory loss;
   behavioural interventions; motor-cognitive stimulation; older people
ID OCCUPATIONAL COMPLEXITY; RESERVE; DEMENTIA; INFLAMMATION; DISEASE;
   MEMORY; RISK; MCI; SEX
AB No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild cognitive impairment (MCI). The 'Train the Brain' programme is a combined motor and cognitive intervention previously shown to markedly improve cognitive functions in MCI individuals compared to non-trained MCI controls, as assessed at the end of the 7-month intervention. Here, we extended the previous analyses to include the long-term effects of the intervention and performed a data disaggregation by gender, education and age of the enrolled participants. We report that the beneficial impact on cognitive functions was preserved at the 14-month follow-up, with greater effects in low-educated compared to high-educated individuals, and in women than in men.
C1 [Sale, Alessandro; Braschi, Chiara; Berardi, Nicoletta; Maffei, Lamberto] CNR, Neurosci Inst, Natl Res Council, Via Moruzzi 1, I-56124 Pisa, Italy.
   [Noale, Marianna; Maggi, Stefania] CNR, Natl Res Council, Neurosci Inst, Via Giustiniani 2, I-35128 Padua, Italy.
   [Cintoli, Simona; Tognoni, Gloria] Univ Pisa, Dept Clin & Expt Med, Neurol Unit, Pisa, Italy.
   [Cintoli, Simona; Tognoni, Gloria] AOU Pisa, Pisa, Italy.
   [Berardi, Nicoletta] Florence Univ, Dept Neurosci Psychol Drug Res & Child Hlth, Via San Salvi, I-50100 Florence, Italy.
   [Sale, Alessandro] Neurosci Inst CNR, Via Moruzzi 1, I-56124 Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Consiglio Nazionale delle
   Ricerche (CNR); University of Pisa; University of Pisa; Azienda
   Ospedaliero Universitaria Pisana; University of Florence
RP Sale, A (corresponding author), Neurosci Inst CNR, Via Moruzzi 1, I-56124 Pisa, Italy.
EM sale@in.cnr.it
RI Noale, Marianna/IXD-2540-2023; Mainardi, Marco/ACQ-5409-2022
OI Mainardi, Marco/0000-0003-2001-1287
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NR 39
TC 0
Z9 0
U1 7
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-0729
EI 1468-2834
J9 AGE AGEING
JI Age Ageing
PD MAY 1
PY 2023
VL 52
IS 5
AR afad067
DI 10.1093/ageing/afad067
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA F9QK6
UT WOS:000985619100001
PM 37167616
OA Bronze
DA 2023-08-17
ER

PT J
AU Takeda, M
AF Takeda, M
TI Mild cognitive impairment-intervention to dementia prevention
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Meeting Abstract
C1 Osaka Univ, Grad Sch Med, Dept Psychiat & Behav Proteom, Osaka, Japan.
C3 Osaka University
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 1041-6102
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PY 2005
VL 17
SU 2
BP 4
EP 4
PG 1
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 984RQ
UT WOS:000233322400005
DA 2023-08-17
ER

PT J
AU Ansari, Z
AF Ansari, Z.
TI HOMOCYSTEINE AND MILD COGNITIVE IMPAIRMENT: ARE THESE THE TOOLS FOR
   EARLY INTERVENTION IN THE DEMENTIA SPECTRUM?
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Mild cognitive impairment; dementia; hyperhomocysteinaemia; B vitamins;
   early intervention
ID ALZHEIMERS-DISEASE; FOLIC-ACID; RISK; MECHANISMS; DECLINE;
   SUPPLEMENTATION; NEUROTOXICITY; ASSOCIATION; PROGRESSION; VITAMINS
AB Dementia, being a neurodegenerative disease, has devastating consequences not just for the ailing but also for the carers as it has a tremendous negative impact on the quality of life. The pathophysiology of dementia commences far earlier than its diagnosis. Mild cognitive impairment (MCI) is a stage prior to definite dementia. The progression from MCI to dementia is insidious with no definite demarcation, thus making diagnosis clinically difficult at an early stage. This paper attempts to throw light on the epidemiology, risk factors and the aetiopathogenesis of MCI. It further attempts to elaborate on the rate of conversion of MCI to definite dementia and the factors influencing the same. Many established as well as probable, modifiable as well as non-modifiable risk factors influence the progress of MCI to definite dementia. Homocysteine, a sulphur containing amino-acid has been identified as a probable risk factor for the dementia spectrum. Various existing clinical evidences and biological plausibility towards probable link between homocysteine and dementia are discussed in this paper. B vitamin mediated homocysteine reduction and cognitive outcomes demonstrate mixed results. This review attempts to evaluate hyperhomocysteinaemia and MCI as a brain risk marker and assess their potential for future research with a view to attempt early intervention.
C1 [Ansari, Z.] Cipla Ltd, Dept Med Serv, Cipla House,Peninsula Business Pk, Bombay 400013, Maharashtra, India.
RP Ansari, Z (corresponding author), Cipla Ltd, Dept Med Serv, Cipla House,Peninsula Business Pk, Bombay 400013, Maharashtra, India.
EM zarrin.ansari@cipla.com
OI Ansari, Zarrin/0000-0001-5002-3129
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NR 54
TC 8
Z9 10
U1 0
U2 9
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD FEB
PY 2016
VL 20
IS 2
BP 155
EP 160
DI 10.1007/s12603-015-0576-y
PG 6
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA DK1UW
UT WOS:000374701200009
PM 26812511
DA 2023-08-17
ER

PT J
AU Tsolaki, AC
   Tsolaki, M
   Pandria, N
   Lazarou, E
   Gkatzima, O
   Zilidou, V
   Karagianni, M
   Iakovidou-Kritsi, Z
   Kimiskidis, VK
   Bamidis, PD
AF Tsolaki, Anthoula C.
   Tsolaki, Magda
   Pandria, Niki
   Lazarou, Eftychia
   Gkatzima, Olymbia
   Zilidou, Vasiliki
   Karagianni, Maria
   Iakovidou-Kritsi, Zafiroula
   Kimiskidis, Vasilios K.
   Bamidis, Panagiotis D.
TI Web-Based Intervention Effects on Mild Cognitive Impairment Based on
   Apolipoprotein E Genotype: Quasi-Experimental Study
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE mild cognitive impairment; APOE epsilon 4; computerized training;
   exergaming; Alzheimer disease
ID VERBAL-LEARNING TEST; ALZHEIMERS-DISEASE; INSTRUMENTAL ACTIVITIES; APOE
   EPSILON-4; OLDER-ADULTS; DEMENTIA; HEALTHY; RISK; INDIVIDUALS;
   RELIABILITY
AB Background: Apolipoprotein E (APOE) epsilon 4 allele is a major genetic risk factor for Alzheimer disease and mild cognitive impairment (MCI). Computer-based training programs can improve cognitive performance in elderly populations. However, the effects of computer-based interventions on MCI APOE epsilon 4 carriers have never been studied before.
   Objective: The effects of different web-based interventions and the APOE isoform-specific differences in training outcomes are investigated.
   Methods: Using a quasi-experimental study design, 202 participants with MCI aged 60 years and older took part in three different intervention programs (physical and cognitive [Long-Lasting Memories, or LLM], cognitive [Active Control, or AC], or physical intervention [Physical Training Control, or PTC]) via an innovative information and communication technologies exergaming platform. Participants in each interventional group were subdivided into APOE epsilon 4 carriers and non-APOE epsilon 4 carriers. All participants underwent an extensive neuropsychological evaluation before and after the training, blood tests, and brain imaging.
   Results: All interventions resulted in multiple statistically significant cognitive benefits after the intervention. Verbal learning (California Verbal Learning Test: immediate recall test score-LLM: P=.04; AC: P<.001), working memory (digit span forward and backward test scores-AC: P=.03; PTC: P=.02 and P=.006, respectively), and long-term memory (California Verbal Learning Test: delayed recall test score-LLM: P=.02; AC: P=.002; and PTC: P=.02) were improved. There was no statistically significant difference among the intervention effects. APOE epsilon 4 presence moderates intervention effects as the LLM intervention improved only their task-switching processing speed (Trail Making Test, Part B: P=.03) and the PTC intervention improved only the working memory (digit span backward: P=.03). No significant performance alteration was noted for the APOE epsilon 4+ cognitive AC training group.
   Conclusions: None of the applied interventions could be identified as the optimal one; it is suggested, however, that combined cognitive and physical training and physical training via exergaming may be more effective for the high-risk MCI APOE epsilon 4+ subgroup.
C1 [Tsolaki, Anthoula C.; Pandria, Niki; Zilidou, Vasiliki; Karagianni, Maria; Bamidis, Panagiotis D.] Aristotle Univ Thessaloniki, Sch Med, Med Phys Lab, POB 376, Thessaloniki, Greece.
   [Tsolaki, Anthoula C.] Agios Pavlos Gen Hosp, Dept Neurol, Thessaloniki, Greece.
   [Tsolaki, Magda; Lazarou, Eftychia] Aristotle Univ Thessaloniki, Amer Hellen Educ Progress Assoc Hosp, Dept Neurol 1, Thessaloniki, Greece.
   [Gkatzima, Olymbia] Panhellen Inst Neurodegenerat Dis, Thessaloniki, Greece.
   [Iakovidou-Kritsi, Zafiroula] Aristotle Univ Thessaloniki, Sch Med, Lab Med Biol Genet Dept, Thessaloniki, Greece.
   [Kimiskidis, Vasilios K.] Aristotle Univ Thessaloniki, Amer Hellen Educ Progress Assoc Hosp, Lab Clin Neurophysiol, Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki; Aristotle University
   of Thessaloniki
RP Bamidis, PD (corresponding author), Aristotle Univ Thessaloniki, Sch Med, Med Phys Lab, POB 376, Thessaloniki, Greece.
EM pdbamidis@gmail.com
RI Zilidou, Vasiliki/AGY-4557-2022
OI Tsolaki, Magda/0000-0002-2072-8010; Tsolaki,
   Anthoula/0000-0002-5563-7776; Kimiskidis, Vasilios/0000-0002-3335-3019;
   Zilidou, Vasiliki/0000-0002-4859-6996; Pandria,
   Niki/0000-0002-7130-5739; Bamidis, Panagiotis/0000-0002-9936-5805
FU LLM Care - ICT-CIP-PSP (Information and Communication
   Technologies-Competitiveness and Innovation Framework Programme-Policy
   Support Programme) Program of the European Commission
FX This research did not receive any specific grant from funding agencies
   in the public, commercial, or not-for-profit sectors. However, parts of
   this work were supported by the LLM Care [58] self-funded initiative
   that emerged as the not-for-profit business exploitation of the
   Long-Lasting Memories (LLM Project) [78] originally funded by the
   ICT-CIP-PSP (Information and Communication Technologies-Competitiveness
   and Innovation Framework Programme-Policy Support Programme) Program of
   the European Commission.
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NR 76
TC 3
Z9 3
U1 0
U2 9
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD MAY 7
PY 2020
VL 22
IS 5
AR e14617
DI 10.2196/14617
PG 20
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Medical Informatics
GA LK3HN
UT WOS:000530752900001
PM 32379048
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Chang, LH
   Chen, PY
   Wang, J
   Shih, BH
   Tseng, YH
   Mao, HF
AF Chang, Ling-Hui
   Chen, Po-Yen
   Wang, Jye
   Shih, Bin-Huei
   Tseng, Yu-Hsuan
   Mao, Hui-Fen
TI High-Ecological Cognitive Intervention to Improve Cognitive Skills and
   Cognitive-Functional Performance for Older Adults With Mild Cognitive
   Impairment
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Article
ID MEMORY
AB Importance: Evidence of the effectiveness of cognitive activity and preparatory tasks in improving the cognitive skills and functional performance of people with cognitive decline is limited.
   Objective: To examine the efficacy of a high-ecological cognitive intervention.
   Design: Quasi-experimental, pretest-posttest design with nonequivalent control.
   Setting: Community.
   Participants: Older adults with mild cognitive impairment from two senior centers.
   Intervention: Twelve 90-min weekly group sessions of a high-ecological cognitive intervention using simulated everyday cognitive tasks (experimental group) and of nutrition education (active control group).
   Outcomes and Measures: Cognitive skills were measured with the Color Trails Test (CTT), the Contextual Memory Test (CMT; Immediate Recall [CMT-Im] and Delayed Recall [CMT-De] tasks), and the Wechsler Adult Intelligence Scale-Fourth Edition Digit Span subtest (Digits Forward and Digits Backward). Cognitive-functional performance was measured with the Rivermead Behavioural Memory Test-Third Edition (RBMT-3; Immediate Recall [RBMT-3-Im] and Delayed Recall [RBMT-3-De] tasks) and the Cognitive Failures Questionnaire (CFQ).
   Results: Thirty-seven participants (M age = 70.84 yr; 70.3% women) met the inclusion criteria for analysis (20 participants in the intervention group, 17 participants in the control group). Multivariate linear regression showed that the intervention group improved significantly more than the control group on the CTT, CMT-Im, and RBMT-3-Im but not on the CMT-De, RBMT-3-De, and CFQ.
   Conclusions and Relevance: Twelve 90-min weekly group sessions of a high-ecological cognitive intervention improved attention, executive function, immediate memory, and objective cognitive-functional performance with immediate-memory task demands.
   What This Article Adds: Carefully designed and structured simulated everyday cognitive tasks can be used as a cognitive training agent to improve both cognitive skills and objective cognitive-functional performance. The effectiveness of group-based cognitive interventions depends on the skills of occupational therapy practitioners in activity analysis and grading.
C1 [Chang, Ling-Hui; Tseng, Yu-Hsuan] Natl Cheng Kung Univ, Coll Med, Dept Occupat Therapy, Tainan, Taiwan.
   [Chang, Ling-Hui; Shih, Bin-Huei] Natl Cheng Kung Univ, Coll Med, Inst Allied Hlth Sci, Tainan, Taiwan.
   [Chen, Po-Yen] Jianan Psychiat Ctr, Dept Occupat Therapy, Tainan, Taiwan.
   [Wang, Jye] Chang Jung Christian Univ, Dept Hlth Care Adm, Tainan, Taiwan.
   [Mao, Hui-Fen] Natl Taiwan Univ, Sch Occupat Therapy, Coll Med, Taipei, Taiwan.
   [Mao, Hui-Fen] Natl Taiwan Univ Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; Chang
   Jung Christian University; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital
RP Mao, HF (corresponding author), Natl Taiwan Univ, Sch Occupat Therapy, Coll Med, Taipei, Taiwan.; Mao, HF (corresponding author), Natl Taiwan Univ Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
EM huifen02@gmail.com
OI Chang, Ling Hui/0000-0003-4129-6947
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NR 25
TC 2
Z9 2
U1 3
U2 4
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
EI 1943-7676
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2021
VL 75
IS 5
AR 7505205050
DI 10.5014/ajot.2021.041996
PG 8
WC Rehabilitation
WE Social Science Citation Index (SSCI)
SC Rehabilitation
GA YK3ER
UT WOS:000745101100016
PM 34780638
DA 2023-08-17
ER

PT J
AU Won, J
   Callow, DD
   Pena, GS
   Jordan, LS
   Arnold-Nedimala, NA
   Nielson, KA
   Smith, JC
AF Won, Junyeon
   Callow, Daniel D.
   Pena, Gabriel S.
   Jordan, Leslie S.
   Arnold-Nedimala, Naomi A.
   Nielson, Kristy A.
   Smith, J. Carson
TI Hippocampal Functional Connectivity and Memory Performance After
   Exercise Intervention in Older Adults with Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Exercise training; functional connectivity; hippocampus; memory; mild
   cognitive impairment; older adults
ID ALZHEIMERS-DISEASE; CARDIORESPIRATORY FITNESS; SYNAPTIC PLASTICITY;
   AEROBIC EXERCISE; ACTIVATION; BRAIN; VOLUME; RISK; DYSFUNCTION;
   POSTERIOR
AB Background: Exercise training (ET) has neuroprotective effects in the hippocampus, a key brain region for memory that is vulnerable to age-related dysfunction.
   Objective: We investigated the effects of ET on functional connectivity (FC) of the hippocampus in older adults with mild cognitive impairment (MCI) and a cognitively normal (CN) control group. We also assessed whether the ET-induced changes in hippocampal FC (Delta hippocampal-FC) are associated with changes in memory task performance (Delta memory performance).
   Methods: 32 older adults (77.0 +/- 7.6 years; 16 MCI and 16 CN) participated in the present study. Cardiorespiratory fitness tests, memory tasks (Rey Auditory Verbal Learning Test (RAVLT) and Logical Memory Test (LM)), and resting-state fMRI were administered before and after a 12-week walking ET intervention. We utilized a seed-based correlation analysis using the bilateral anterior and posterior hippocampi as priori seed regions of interest. The associations of residualized ET-induced Delta hippocampal-FC and Delta memory performance were assessed using linear regression.
   Results: There were significant improvements in RAVLT Trial 1 and LM test performance after ET across participants. At baseline, MCI, compared to CN, demonstrated significantly lower posterior hippocampal FC. ET was associated with increased hippocampal FC across groups. Greater ET-related anterior and posterior hippocampal FC with right posterior cingulate were associated with improved LM recognition performance in MCI participants.
   Conclusion: Our findings indicate that hippocampal FC is significantly increased following 12-weeks of ET in older adults and, moreover, suggest that increased hippocampal FC may reflect neural network plasticity associated with ET-related improvements in memory performance in individuals diagnosed with MCI.
C1 [Won, Junyeon; Callow, Daniel D.; Pena, Gabriel S.; Jordan, Leslie S.; Arnold-Nedimala, Naomi A.; Smith, J. Carson] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA.
   [Callow, Daniel D.; Jordan, Leslie S.; Smith, J. Carson] Univ Maryland, Program Neurosci & Cognit Sci, College Pk, MD 20742 USA.
   [Nielson, Kristy A.] Marquette Univ, Dept Psychol, Milwaukee, WI 53233 USA.
   [Nielson, Kristy A.] Med Coll Wisconsin, Dept Neuropsychol, Milwaukee, WI 53226 USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   Marquette University; Medical College of Wisconsin
RP Smith, JC (corresponding author), Univ Maryland, Sch Publ Hlth, Dept Kinesiol, 2351 SPH Bldg 255, College Pk, MD 20742 USA.
EM carson@umd.edu
RI Callow, Daniel/IZE-6605-2023
OI Callow, Daniel/0000-0003-0843-6602; Nielson, Kristy/0000-0001-8977-3138;
   Won, Junyeon/0000-0001-7900-9355; Jordan, Leslie/0000-0002-8236-0426;
   Pena, Gabriel S./0000-0003-4151-1141
FU University of Wisconsin-Milwaukee Graduate School Research Growth
   Initiative; National Center for Advancing Translational Sciences, NIH
   [8UL1TR000055, 8KL2TR000056]
FX We thank the participants for their dedication while participating in
   this study, Drs. Nathan Hantke and Alissa Butts for their assistance
   with participant assessment, and Dr. Piero Antuono for his role in
   diagnosis of MCI. This study was supported by the University of
   Wisconsin-Milwaukee Graduate School Research Growth Initiative; and the
   National Center for Advancing Translational Sciences, NIH grant numbers
   8UL1TR000055, 8KL2TR000056. The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   NIH.
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NR 72
TC 12
Z9 12
U1 2
U2 11
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2021
VL 82
IS 3
BP 1015
EP 1031
DI 10.3233/JAD-210051
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA TX3YV
UT WOS:000683026700013
PM 34151792
OA hybrid, Green Published
DA 2023-08-17
ER

PT J
AU Couch, E
   Lawrence, V
   Co, M
   Prina, M
AF Couch, Elyse
   Lawrence, Vanessa
   Co, Melissa
   Prina, Matthew
TI Outcomes tested in non-pharmacological interventions in mild cognitive
   impairment and mild dementia: a scoping review
SO BMJ OPEN
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; OLDER-ADULTS;
   ALZHEIMERS-DISEASE; WORKING-MEMORY; MULTICOMPONENT INTERVENTION;
   SINGLE-BLIND; INDIVIDUALS; EXERCISE; RISK
AB Objectives Non-pharmacological treatments are an important aspect of dementia care. A wide range of interventions have been trialled for mild dementia and mild cognitive impairment (MCI). However, the variety of outcome measures used in these trials makes it difficult to make meaningful comparisons. The objective of this study is to map trends in which outcome measures are used in trials of non-pharmacological treatments in MCI and mild dementia.
   Design Scoping review.
   Data sources EMBASE, PsychINFO, Medline and the Cochrane Register of Controlled Trials were searched from inception until February 2018. An additional search was conducted in April 2019
   Eligibility We included randomised controlled trials (RCTs) testing non-pharmacological interventions for people diagnosed with MCI or mild dementia. Studies were restricted to full RCTs; observational, feasibility and pilot studies were not included.
   Charting methods All outcome measures used by included studies were extracted and grouped thematically. Trends in the types of outcome measures used were explored by type of intervention, country and year of publication.
   Results 91 studies were included in this review. We extracted 358 individual outcome measures, of which 78 (22%) were used more than once. Cognitive measures were the most frequently used, with the Mini-Mental State Examination being the most popular.
   Conclusions Our findings highlight an inconsistency in the use of outcome measures. Cognition has been prioritised over other domains, despite previous research highlighting the importance of quality of life and caregiver measures. To ensure a robust evidence base, more research is needed to highlight which outcome measures should be used over others.
C1 [Couch, Elyse; Lawrence, Vanessa; Co, Melissa; Prina, Matthew] Kings Coll London, Hlth Serv & Populat Re s, London, England.
C3 University of London; King's College London
RP Couch, E (corresponding author), Kings Coll London, Hlth Serv & Populat Re s, London, England.
EM elyse.couch@kcl.ac.uk
RI Prina, Matthew/B-4188-2013; Lawrence, Vanessa/E-8391-2017
OI Prina, Matthew/0000-0001-6698-3263; Lawrence,
   Vanessa/0000-0001-7852-2018; Couch, Elyse/0000-0003-4692-5837
FU ESRC LISS-DTP; Economic and Social Research Council [1916656] Funding
   Source: researchfish; ESRC [1916656] Funding Source: UKRI
FX EC is supported by a studentship from the ESRC LISS-DTP.
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NR 118
TC 16
Z9 16
U1 1
U2 10
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD APR
PY 2020
VL 10
IS 4
AR e035980
DI 10.1136/bmjopen-2019-035980
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA LV0RG
UT WOS:000538150800107
PM 32317262
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Clynes, J
   Blackman, J
   Swirski, M
   Leng, Y
   Harding, S
   Coulthard, E
AF Clynes, J.
   Blackman, J.
   Swirski, M.
   Leng, Y.
   Harding, S.
   Coulthard, E.
CA ReMemBr Grp
TI INTERVENTIONS TO ENHANCE SLEEP IN MILD COGNITIVE IMPAIRMENT AND MILD
   ALZHEIMER'S DEMENTIA: A SYSTEMATIC REVIEW
SO SLEEP MEDICINE
LA English
DT Meeting Abstract
C1 [Clynes, J.] Univ Bath, Hlth, Bath, Avon, England.
   [Blackman, J.; Swirski, M.; Harding, S.; Coulthard, E.] Univ Bristol, Bristol, Avon, England.
   [Leng, Y.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
C3 University of Bath; University of Bristol; University of California
   System; University of California San Francisco
OI Harding, Sam/0000-0002-5870-2094
FU North Bristol NHS Trust; National Institute of Health Research through
   Research Capability Funding
FX North Bristol NHS Trust and National Institute of Health Research
   through Research Capability Funding.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD DEC
PY 2019
VL 64
SU 1
BP S77
EP S77
PG 1
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA MY9UT
UT WOS:000558768400211
DA 2023-08-17
ER

PT J
AU DeFeis, B
   Ying, GL
   Kurasz, AM
   De Wit, L
   Amofa, P
   Chandler, M
   Locke, D
   Shandera-Ochsner, A
   Phatak, V
   Smith, G
AF DeFeis, Brittany
   Ying, Gelan
   Kurasz, Andrea M.
   De Wit, Liselotte
   Amofa, Priscilla
   Chandler, Melanie
   Locke, Dona
   Shandera-Ochsner, Anne
   Phatak, Vaishali
   Smith, Glenn
TI Latent Factor Structure of Outcome Measures Used in the HABIT (R) Mild
   Cognitive Impairment Intervention Programs
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Behavioral intervention; caregiver burden; factor analysis; functional
   status; mild cognitive impairment
ID FUNCTIONAL-ACTIVITIES; ZARIT BURDEN; OLDER-ADULTS; VERSION; SCALE;
   INTERVIEW; VALIDITY; UTILITY; DESIGN
AB Background: In Alzheimer's disease and related disorders (ADRD) research, common outcome measures include cognitive and functional impairment, as well as persons with mild cognitive impairment (pwMCI) and care partner self-reported mood and quality of life. Studies commonly analyze these measures separately, which potentially leads to issues of multiple comparisons and/or multicollinearity among measures while ignoring the latent constructs they may be measuring.
   Objective: This study sought to examine the latent factor structure of a battery of 12-13 measures of domains mentioned above, used in a multicomponent behavioral intervention (The HABIT (R) program) for pwMCI and their partners.
   Methods: Exploratory factor analysis (EFA) involved 214 pwMCI-partner pairs. Subsequent Confirmatory factor analyses (CFA) used 730 pairs in both pre- and post-intervention conditions.
   Results: EFA generated a three-factor model. Factors could be characterized as partner adjustment (29.9%), pwMCI adjustment (18.1%), and pwMCI impairment (12.8%). The subsequent CFA confirmed our findings, and the goodness-of-fit for this model was adequate in both the pre- (CFI = 0.937; RMSEA= 0.057, p = 0.089) and post-intervention (CFI = 0.942; RMSEA= 0.051, p = 0.430) groups.
   Conclusion: Results demonstrated a stable factor structure across cohorts and intervention conditions suggesting that three broad factors may provide a straightforward and meaningful model to assess intervention outcome, at least during the MCI phase of ADRD.
C1 [DeFeis, Brittany; Ying, Gelan; Kurasz, Andrea M.; De Wit, Liselotte; Amofa, Priscilla; Smith, Glenn] Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
   [Chandler, Melanie] Mayo Clin Florida, Dept Psychiat & Psychol, Jacksonville, FL USA.
   [Locke, Dona] Mayo Clin Arizona, Dept Psychiat & Psychol, Scottsdale, AZ USA.
   [Shandera-Ochsner, Anne] Mayo Clin Midwest, Dept Psychiat & Psychol, La Crosse, WI USA.
   [Phatak, Vaishali] Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE USA.
C3 State University System of Florida; University of Florida; Mayo Clinic;
   Mayo Clinic; Mayo Clinic Phoenix; University of Nebraska System;
   University of Nebraska Medical Center
RP Smith, G (corresponding author), Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
EM glennsmith@ufl.edu
RI Ying, Gelan/GXG-3491-2022
OI DeFeis, Brittany/0000-0003-2763-7098; Mejia Kurasz,
   Andrea/0000-0002-6523-4081
FU Patient-Centered Outcomes Research Institute (PCORI) Award
   [CER-1306-01897]; National Institute of Nursing Research [R01NR012419];
   Alzheimer's Association [NIRG-07-58843]; Florida Department of Health Ed
   and Ethel Moore Alzheimer's Disease Research Program [7AZ-01]; Ralph C
   Wilson Foundation from the Alzheimer's Disease Research Centers at Mayo
   Clinic [P30AG06267, AZ P30AG01961]; University of Washington
   [P30AG005036]; University of Florida [P30AG066506]
FX Research reported in this manuscript was partially funded through a
   Patient-Centered Outcomes Research Institute (PCORI) Award
   (CER-1306-01897), the National Institute of Nursing Research
   (R01NR012419), the Alzheimer's Association (NIRG-07-58843), The Florida
   Department of Health Ed and Ethel Moore Alzheimer's Disease Research
   Program (7AZ-01) and the Ralph C Wilson Foundation Additional support
   was received from the Alzheimer's Disease Research Centers at Mayo
   Clinic (MN and Jax; P30AG06267 and AZ P30AG01961) the University of
   Washington (P30AG005036) and the University of Florida (P30AG066506).
   The statements in this publication are solely the responsibility of the
   authors and do not represent the views of any of the sources of funding.
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NR 51
TC 0
Z9 0
U1 0
U2 0
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2021
VL 84
IS 1
BP 193
EP 205
DI 10.3233/JAD-210582
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA XD3VD
UT WOS:000722639900016
PM 34511501
DA 2023-08-17
ER

PT J
AU Li, M
   Liu, L
   Tian, G
AF Li, Min
   Liu, Lei
   Tian, Gang
TI EFFECT OF LONG-TERM LIFESTYLE INTERVENTION ON MILD COGNITIVE IMPAIRMENT
   IN HYPERTENSIVE OCCUPATIONAL POPULATION IN CHINA
SO JOURNAL OF HYPERTENSION
LA English
DT Meeting Abstract
CT 27th Scientific Meeting of the International-Society-of-Hypertension
CY SEP 20-23, 2018
CL Beijing, PEOPLES R CHINA
SP Int Soc Hypertens
DE Lifestyle Intervention; MCI; Hypertension; Occupational Population
C1 [Li, Min; Liu, Lei; Tian, Gang] Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD OCT
PY 2018
VL 36
SU 3
MA A9796
BP E311
EP E311
DI 10.1097/01.hjh.0000549269.67051.5f
PG 1
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA HH3BV
UT WOS:000455594806050
DA 2023-08-17
ER

PT J
AU Li, M
   Liu, L
   Song, SW
   Shi, AS
   Ma, YL
   Zhang, SL
   Wang, ZW
   Zhu, DJ
   Tian, G
AF Li, Min
   Liu, Lei
   Song, Shaowu
   Shi, Anshi
   Ma, Yunlong
   Zhang, Songlin
   Wang, Zengwu
   Zhu, Danjun
   Tian, Gang
TI Effect of long-term lifestyle intervention on mild cognitive impairment
   in hypertensive occupational population in China
SO MEDICINE
LA English
DT Article
DE hypertension; lifestyle intervention; mild cognitive impairment;
   occupational population
ID BLOOD-PRESSURE; WORKING POPULATION; DEMENTIA; PREVALENCE; DISEASE;
   DECLINE; HEALTH; RISK
AB Background: The incidence of hypertension in China is high, which seriously affects people's health, including occupational population in mining areas. Cognitive dysfunction has a serious impact on the work and life of patients. Lifestyle intervention can improve diabetes and cardiovascular diseases. However, there are few studies on the effects of lifestyle interventions on cognitive function in hypertensive patients. So the aim of this study was to analyze the effect of long-term lifestyle intervention on mild cognitive impairment in hypertensive occupational population in China.
   Methods: In September 2013, a cluster sampling was conducted for the workers in the Shaanxi Jinduicheng (intervention group) and Hancheng (control group) mining areas. In both groups, according to the blood pressure (BP) level, they were divided into hypertension stage 1 to 3 subgroups; according to their age, they were divided into between 45 and 59 and under 45 years subgroups; and according to whether or not taking medicine, they were divided into Lifestyle intervention, Lifestyle intervention plus medication, Medication, and No lifestyle intervention nor medication subgroups. The intervention group received regular lifestyle intervention for 2 years, which included diet, smoke, drink, and exercise intervention. Mild cognitive impairment was measured by the Montreal Cognitive Assessment (MoCA). The arterial stiffness was measured by Omron Automatic Atherosclerosis Tester. We conducted BP measurement and MoCA questionnaire at baseline, 6, 12, and 24 months.
   Results: We analyzed a total of 510 mine workers, whose average age was 45.6 +/- 13.4 years old. With the increase of BP level, the MoCA scores decreased significantly both in control and lifestyle intervention groups (P<.05). There was no obvious difference between the hypertensive patients whose age was between 45 and 59 to those under 45 in MoCA scores (P>.05). After 2 years, the BP, total cholesterol, glucose, and brachial-ankle pulse wave velocity of the Lifestyle intervention subgroup and Lifestyle intervention plus medication subgroup decreased (P<.05), and the MoCA scores and ankle-brachial index increased (P<.05), and the latter improved more significantly. Compared with the No lifestyle intervention nor medication subgroup, the BP and MoCA scores had no obvious changes at 6 months (P>.05), but the BP decreased and the MoCA scores increased significantly in the Lifestyle intervention and Lifestyle intervention plus medication subgroups after 1 and 2 years of lifestyle intervention (P<.05).
   Conclusion: Long-term lifestyle intervention can be used as adjunctive therapy to improve the BP and cognitive function of hypertensive occupational population in China.
C1 [Li, Min; Liu, Lei; Ma, Yunlong; Zhang, Songlin; Zhu, Danjun; Tian, Gang] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiol, 277 Yanta W Rd, Xian 710061, Shaanxi, Peoples R China.
   [Song, Shaowu] Jinduicheng Molybdenum Co Employees Hosp, Weinan, Shaanxi, Peoples R China.
   [Shi, Anshi] Hancheng Min Bur Gen Hosp, Weinan, Shaanxi, Peoples R China.
   [Wang, Zengwu] Chinese Acad Med Sci, Hypertens Ctr, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China.
   [Wang, Zengwu] Peking Union Med Coll, Beijing, Peoples R China.
C3 Xi'an Jiaotong University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Fu Wai Hospital - CAMS; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Peking Union Medical
   College
RP Zhu, DJ; Tian, G (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiol, 277 Yanta W Rd, Xian 710061, Shaanxi, Peoples R China.
EM zhudanjun9@hotmail.com; tiangang@xjtu.edu.cn
RI wang, zengwu/AAS-9504-2021
OI wang, zengwu/0000-0003-1613-5076
FU National "12th Five-Year" science and technology support program
   "China's major cardiovascular disease investigation and key technology
   research" [2011BAI11B01]; Natural Science Foundation of China [30871042,
   81600574]; Shaanxi Province Science and Technology Research and
   Development Program International Science and Technology Cooperation and
   Exchange Project [2012 kw-40-01]; Shaanxi Province Science and
   Technology Research and Development Plan of Natural Science Basic
   Research Program [2014 JM2-8145]
FX This work was supported by the National "12th Five-Year" science and
   technology support program "China's major cardiovascular disease
   investigation and key technology research" (No. 2011BAI11B01), the
   Natural Science Foundation of China (No. 30871042 and 81600574), the
   Shaanxi Province Science and Technology Research and Development Program
   International Science and Technology Cooperation and Exchange Project
   (No. 2012 kw-40-01), and the Shaanxi Province Science and Technology
   Research and Development Plan of Natural Science Basic Research Program
   (No. 2014 JM2-8145).
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NR 31
TC 6
Z9 8
U1 2
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2018
VL 97
IS 34
AR e11975
DI 10.1097/MD.0000000000011975
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GW0XD
UT WOS:000446592300079
PM 30142828
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Yuan, YX
   Li, XF
   Liu, WX
AF Yuan, Yuxin
   Li, Xiaofen
   Liu, Wanxu
TI Dance activity interventions targeting cognitive functioning in older
   adults with mild cognitive impairment: A meta-analysis
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE dance activity; dance exercise; MCI; cognitive function; meta-analysis
ID MUSIC-THERAPY; EXERCISE; MEMORY; PLASTICITY; EXPERIENCE; DEMENTIA;
   PEOPLE
AB ObjectivesTo comprehensively determine the effect of dance activities on the cognitive functions and its sub-domains of older adults with mild cognitive impairment (MCI).MethodsWe obtained data from PubMed, Web of Science, EBSCO, China national knowledge infrastructure, Wanfang data, and VIP databases from 2017/01/01 to 2022/03/01. We included trials of older adults with MCI that underwent dance activity intervention and fulfilled the inclusion criteria. Two researchers independently assessed the quality of the study using the Cochrane risk of the bias assessment tool. Meta-analysis was performed when data were available, with further subgroup analysis, using Review Manager 5.4, and sensitivity analysis was performed using Stata software 15.1.ResultsSearch terms yielded 183 articles, of which 12 fulfilled the inclusion criteria. This included 7 high-quality studies and 5 medium-quality studies. A total of 820 older adults were analyzed. Results showed that dance activity had beneficial effects for global cognition [SMDMMSE = 0.65, 95% CIMMSE (0.20, 1.09), p(MMSE) = 0.004; SMDMoCA = 0.87, 95% CIMoCA (0.44, 1.29), p(MoCA) < 0.0001], memory [SMD = 0.61, 95% CI (0.35, 0.88), p < 0.00001], visuospatial function [SMD = -0.39, 95% CI (-0.60, -0.19), p = 0.0002], cognitive flexibility [SMD = -0.31, 95% CI (-0.52, -0.11), p = 0.003], attention [SMD = 0.34, 95% CI (0.07, 0.61), p = 0.01], and balance [SMD = 1.25, 95% CI (0.06, 2.44), p = 0.04]. Further subgroup analysis showed that open-skill dance activity (OSDA) was more effective in promoting global cognition in older adults with MCI than closed-skill dance activity (CSDA) because of the different stimulation provided by the two types of dance activities in the brain regions of the older adults (p = 0.0002). It could be speculated that dance activity improved cognitive function mainly by affecting the microstructure and function of the cingulate tract, hippocampus, cardiovascular function, and other brain areas of older adults with MCI.ConclusionDance activities can significantly improve global cognition, memory, visuospatial function, cognitive flexibility, attention, and balance in older adults with MCI. However, more trials with rigorous study designs are necessary to provide more concrete evidence in the future.
C1 [Yuan, Yuxin; Li, Xiaofen; Liu, Wanxu] Beijing Sport Univ, Sch Art, Beijing, Peoples R China.
C3 Beijing Sport University
RP Li, XF (corresponding author), Beijing Sport Univ, Sch Art, Beijing, Peoples R China.
EM Lixf@bsu.edu.cn
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NR 71
TC 1
Z9 1
U1 15
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD SEP 27
PY 2022
VL 13
AR 966675
DI 10.3389/fpsyg.2022.966675
PG 16
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 5T0OK
UT WOS:000875577300001
PM 36237681
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Power, R
   Nolan, JM
   Prado-Cabrero, A
   Coen, R
   Roche, W
   Power, T
   Howard, AN
   Mulcahy, R
AF Power, Rebecca
   Nolan, John M.
   Prado-Cabrero, Alfonso
   Coen, Robert
   Roche, Warren
   Power, Tommy
   Howard, Alan N.
   Mulcahy, Riona
TI Targeted Nutritional Intervention for Patients with Mild Cognitive
   Impairment: The Cognitive impAiRmEnt Study (CARES) Trial 1
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE mild cognitive impairment; nutrition; omega-3 fatty acids; antioxidant;
   carotenoids; vitamin E; cognition; episodic memory; older adults; ageing
ID ALZHEIMERS-DISEASE; MEDITERRANEAN DIET; DOCOSAHEXAENOIC ACID; MACULAR
   PIGMENT; OMEGA-3-FATTY-ACID SUPPLEMENTATION; OLDER-ADULTS; DOUBLE-BLIND;
   DEMENTIA; CAROTENOIDS; MEMORY
AB Omega-3 fatty acids (omega-3FAs), carotenoids, and vitamin E are important constituents of a healthy diet. While they are present in brain tissue, studies have shown that these key nutrients are depleted in individuals with mild cognitive impairment (MCI) in comparison to cognitively healthy individuals. Therefore, it is likely that these individuals will benefit from targeted nutritional intervention, given that poor nutrition is one of the many modifiable risk factors for MCI. Evidence to date suggests that these nutritional compounds can work independently to optimize the neurocognitive environment, primarily due to their antioxidant and anti-inflammatory properties. To date, however, no interventional studies have examined the potential synergistic effects of a combination of omega-3FAs, carotenoids and vitamin E on the cognitive function of patients with MCI. Individuals with clinically confirmed MCI consumed an omega-3FA plus carotenoid plus vitamin E formulation or placebo for 12 months. Cognitive performance was determined from tasks that assessed global cognition and episodic memory. omega-3FAs, carotenoids, and vitamin E were measured in blood. Carotenoid concentrations were also measured in tissue (skin and retina). Individuals consuming the active intervention (n= 6; median [IQR] age 73.5 [69.5-80.5] years; 50% female) exhibited statistically significant improvements (p< 0.05, for all) in tissue carotenoid concentrations, and carotenoid and omega-3FA concentrations in blood. Trends in improvements in episodic memory and global cognition were also observed in this group. In contrast, the placebo group (n= 7; median [IQR] 72 (69.5-75.5) years; 89% female) remained unchanged or worsened for all measurements (p> 0.05). Despite a small sample size, this exploratory study is the first of its kind to identify trends in improved cognitive performance in individuals with MCI following supplementation with omega-3FAs, carotenoids, and vitamin E.
C1 [Power, Rebecca; Nolan, John M.; Prado-Cabrero, Alfonso; Roche, Warren; Power, Tommy] Waterford Inst Technol, Sch Hlth Sci, Nutr Res Ctr Ireland, Carriganore House,West Campus, Waterford X91 K0EK, Ireland.
   [Coen, Robert] St James Hosp, Mercers Inst Res Ageing, Dublin D08 NHY1, Ireland.
   [Howard, Alan N.] Howard Fdn, 7 Marfleet Close, Cambridge CB22 5LA, England.
   [Mulcahy, Riona] Univ Hosp Waterford, Age Related Care Unit, Dunmore Rd, Waterford X91 ER8E, Ireland.
   [Mulcahy, Riona] Royal Coll Surgeons Ireland, 123 Stephens Green, Dublin D02 YN77, Ireland.
C3 South East Technological University (SETU); Trinity College Dublin;
   Royal College of Surgeons - Ireland
RP Power, R (corresponding author), Waterford Inst Technol, Sch Hlth Sci, Nutr Res Ctr Ireland, Carriganore House,West Campus, Waterford X91 K0EK, Ireland.; Mulcahy, R (corresponding author), Univ Hosp Waterford, Age Related Care Unit, Dunmore Rd, Waterford X91 ER8E, Ireland.; Mulcahy, R (corresponding author), Royal Coll Surgeons Ireland, 123 Stephens Green, Dublin D02 YN77, Ireland.
EM rpower@wit.ie; jmnolan@wit.ie; aprado-cabrero@wit.ie; rcoen@stjames.ie;
   warren.roche@ucdconnect.ie; tbpower@wit.ie;
   alan.howard@howard-foundation.com; drriona.mulcahy@hse.ie
RI Prado-Cabrero, Alfonso/M-2504-2019
OI Prado-Cabrero, Alfonso/0000-0001-8268-5362; Power,
   Rebecca/0000-0002-8493-6417
FU Howard Foundation [285822]
FX This research was funded by the Howard Foundation (Registered UK Charity
   Number: 285822).
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NR 93
TC 12
Z9 12
U1 2
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD JUN
PY 2020
VL 10
IS 2
AR 43
DI 10.3390/jpm10020043
PG 29
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA MO5SK
UT WOS:000551585300026
PM 32466168
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Bernini, S
   Panzarasa, S
   Barbieri, M
   Sinforiani, E
   Quaglini, S
   Tassorelli, C
   Bottiroli, S
AF Bernini, Sara
   Panzarasa, Silvia
   Barbieri, Marica
   Sinforiani, Elena
   Quaglini, Silvana
   Tassorelli, Cristina
   Bottiroli, Sara
TI A double-blind randomized controlled trial of the efficacy of cognitive
   training delivered using two different methods in mild cognitive
   impairment in Parkinson's disease: preliminary report of benefits
   associated with the use of a computerized tool
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Computer-based cognitive training; Randomized controlled trial;
   Neurodegenerative disease; Mild cognitive impairment; Parkinson's
   disease; Multi-domain stimulation
ID NORMATIVE VALUES; DIAGNOSTIC-CRITERIA; OLDER-ADULTS; REHABILITATION;
   INDIVIDUALS
AB Background The effectiveness of computer-based cognitive training (CCT) remains controversial, especially in older adults with neurodegenerative diseases. Aims To evaluate the efficacy of CCT in patients with Parkinson's disease and mild cognitive impairment (PD-MCI). Methods In this randomized controlled trial, 53 patients were randomized to receive CCT delivered by means of CoRe software, traditional paper-and-pencil cognitive training (PCT), or an unstructured activity intervention (CG). In each group, the intervention lasted 3 consecutive weeks (4 individual face-to-face sessions/week). Neuropsychological assessment was administered at baseline (T0) and post-intervention (T1). Outcome measures at T0 and T1 were compared within and between groups. The Montreal Overall Cognitive Assessment (MoCA) was taken as the primary outcome measure. Results Unlike the PCT group and the CG, the patients receiving CCT showed significant medium/large effect size improvements in MoCA performance, global cognition, executive functions, and attention/processing speed. No baseline individual/demographic variables were associated with greater gains from the intervention, although a negative correlation with baseline MoCA performance was found. Conclusion CCT proved effective in PD-MCI patients when compared with traditional PCT. Further follow-up assessments are being conducted to verify the retention of the gains and the potential ability of the tool to delay conversion to PD-dementia.
C1 [Bernini, Sara; Barbieri, Marica; Sinforiani, Elena; Tassorelli, Cristina; Bottiroli, Sara] IRCCS Mondino Fdn, Pavia, Italy.
   [Panzarasa, Silvia; Quaglini, Silvana] Univ Pavia, Dept Elect Comp & Biomed Engn, Pavia, Italy.
   [Tassorelli, Cristina] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy.
   [Bottiroli, Sara] Giustino Fortunato Univ, Benevento, Italy.
C3 IRCCS Fondazione Casimiro Mondino; University of Pavia; University of
   Pavia; Universita Telematica Giustino Fortunato
RP Bottiroli, S (corresponding author), IRCCS Mondino Fdn, Pavia, Italy.; Bottiroli, S (corresponding author), Giustino Fortunato Univ, Benevento, Italy.
EM sara.bernini@mondino.it
RI quaglini, silvana/AAC-2687-2022; Bottiroli, Sara/K-7548-2016; Bernini,
   Sara/K-5971-2016
OI quaglini, silvana/0000-0002-4288-2561; Bottiroli,
   Sara/0000-0002-0151-3962; Bernini, Sara/0000-0001-8615-0242
FU Italian Ministry of Health
FX This work was supported by a grant from the Italian Ministry of Health
   (Ricerca Corrente 2017-2019).
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NR 39
TC 12
Z9 13
U1 3
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD JUN
PY 2021
VL 33
IS 6
SI SI
BP 1567
EP 1575
DI 10.1007/s40520-020-01665-2
EA SEP 2020
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA SS1NP
UT WOS:000566878200001
PM 32895890
DA 2023-08-17
ER

PT J
AU Scholey, AB
   Camfield, DA
   Hughes, ME
   Woods, W
   Stough, CKK
   White, DJ
   Gondalia, SV
   Frederiksen, PD
AF Scholey, Andrew B.
   Camfield, David A.
   Hughes, Matthew E.
   Woods, Will
   Stough, Con K. K.
   White, David J.
   Gondalia, Shakuntla V.
   Frederiksen, Pernille D.
TI A randomized controlled trial investigating the neurocognitive effects
   of Lacprodan (R) PL-20, a phospholipid-rich milk protein concentrate, in
   elderly participants with age-associated memory impairment: the
   Phospholipid Intervention for Cognitive Ageing Reversal (PLICAR): study
   protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
ID LECITHIN TRANSPHOSPHATIDYLATED PHOSPHATIDYLSERINE; SCOPOLAMINE-INDUCED
   AMNESIA; DOUBLE-BLIND; ALZHEIMERS-DISEASE; GUT MICROBIOTA; OXIDATIVE
   STRESS; IMPROVES MEMORY; BRAIN PHOSPHATIDYLSERINE; HOMOCYSTEINE
   METABOLISM; ACETYLCHOLINE-RELEASE
AB Background: Age-related cognitive decline (ARCD) is of major societal concern in an ageing population, with the development of dietary supplements providing a promising avenue for amelioration of associated deficits. Despite initial interest in the use of phospholipids (PLs) for ARCD, in recent years there has been a hiatus in such research. Because of safety concerns regarding PLs derived from bovine cortex, and the equivocal efficacy of soybean-derived PLs, there is an important need for the development of new PL alternatives. Phospholipids derived from milk proteins represent one potential candidate treatment.
   Methods: In order to reduce the effects of age-associated memory impairment (AAMI) the Phospholipid Intervention for Cognitive Ageing Reversal (PLICAR) was developed to test the efficacy of a milk protein concentrate rich in natural, non-synthetic milk phospholipids (Lacprodan(R) PL-20). PLICAR is a randomized, double-blind, placebo-controlled parallel-groups study where 150 (N = 50/group) AAMI participants aged >55 years will be randomized to receive a daily supplement of Lacprodan(R) PL-20 or one of two placebos (phospholipid-free milk protein concentrate or inert rice starch) over a 6-month (180-day) period. Participants will undergo testing at baseline, 90 days and 180 days. The primary outcome is a composite memory score from the Rey Auditory Verbal Learning Test. Secondary outcomes include cognitive (verbal learning, working memory, prospective and retrospective memory, processing speed and attention), mood (depression, anxiety, stress and visual analogue scales), cardiovascular (blood pressure, blood velocity and pulse wave pressure), gastrointestinal microbiota and biochemical measures (oxidative stress, inflammation, B vitamins and Homocysteine, glucoregulation and serum choline). Allelic differences in the Apolipoprotein E and (APOE) and Methylenetetrahydrofolate reductase (MTHFR) gene will be included for subgroup analysis. A subset (N = 60; 20/group)) will undergo neuroimaging using functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) in order to further explore in vivo central mechanisms of action of Lacprodan(R) PL-20. This study will enable evaluation of the efficacy of milk-derived phospholipids for AAMI, and their mechanisms of action.
C1 [Scholey, Andrew B.; Camfield, David A.; Stough, Con K. K.; White, David J.; Gondalia, Shakuntla V.] Swinburne Univ Technol, Ctr Human Psychopharmacol, Melbourne, Vic 3122, Australia.
   [Hughes, Matthew E.; Woods, Will] Swinburne Univ Technol, Brain & Psychol Sci Res Ctr, Melbourne, Vic 3122, Australia.
   [Frederiksen, Pernille D.] Arla Food Ingredients, DK-J Viby J, Denmark.
C3 Swinburne University of Technology; Swinburne University of Technology
RP Scholey, AB (corresponding author), Swinburne Univ Technol, Ctr Human Psychopharmacol, Melbourne, Vic 3122, Australia.
EM andrew@scholeylab.com
RI Gondalia, Shakuntla/ABH-9045-2020; Scholey, Andrew/C-5940-2015; Stough,
   Con/A-6492-2015; Scholey, Andrew/GWV-0066-2022
OI Gondalia, Shakuntla/0000-0002-9658-0307; Scholey,
   Andrew/0000-0003-4484-5462; Hughes, Matthew/0000-0001-5057-5556; Woods,
   William/0000-0001-6653-6105; White, David/0000-0001-8694-1474; stough,
   con/0000-0002-3628-3220; Camfield, David/0000-0001-7925-2566
FU Arla Foods, Denmark
FX This study is funded by Arla Foods, Denmark. Author PF is an employee of
   Arla Foods and contributed to the study design and to the manuscript.
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NR 136
TC 11
Z9 11
U1 0
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD NOV 26
PY 2013
VL 14
AR 404
DI 10.1186/1745-6215-14-404
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 276MX
UT WOS:000328755500001
PM 24279904
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Gilbert, B
   Belleville, S
   Mellah, S
   Gauthier, S
AF Gilbert, B
   Belleville, S
   Mellah, S
   Gauthier, S
TI Effect of a multifactorial memory intervention on the subjective
   complaint of persons with mild cognitive impairment
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Meeting Abstract
C1 Univ Montreal, Res Ctr, Inst Univ Geriatr Montreal, Montreal, PQ, Canada.
   McGill Ctr Studies Aging, Montreal, PQ, Canada.
C3 Universite de Montreal; McGill University
NR 0
TC 0
Z9 0
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 1041-6102
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PY 2005
VL 17
SU 2
BP 241
EP 241
PG 1
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 984RQ
UT WOS:000233322400455
DA 2023-08-17
ER

PT J
AU Cassidy-Eagle, EL
   Siebern, A
   Unti, L
   Glassman, J
   Dunn, LB
AF Cassidy-Eagle, Erin L.
   Siebern, Allison
   Unti, Lisa
   Glassman, Jill
   Dunn, Laura B.
TI Non-Pharmacologic Insomnia Intervention for Older Adults with Mild
   Cognitive Impairment: Improvements in Actigraphy-Assessed Sleep
   Parameters
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Association-for-Geriatric-Psychiatry
   (AAGP)
CY MAR 17-20, 2016
CL Washington, DC
SP Amer Assoc Geriatr Psychiat
C1 [Cassidy-Eagle, Erin L.; Siebern, Allison; Dunn, Laura B.] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
   [Cassidy-Eagle, Erin L.; Unti, Lisa; Glassman, Jill] ETR, Scotts Valley, CA USA.
   [Siebern, Allison] Fayetteville NC VA Med Ctr, Fayetteville, NC USA.
C3 Stanford University
FU Retirement Research Foundation [2012-199]
FX This study is supported by Grant #2012-199 from the Retirement Research
   Foundation.
NR 0
TC 0
Z9 0
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD MAR
PY 2016
VL 24
IS 3
SU S
MA NR 32
BP S162
EP S162
DI 10.1016/j.jagp.2016.02.035
PG 1
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Geriatrics & Gerontology; Psychiatry
GA FE9RU
UT WOS:000408541600155
DA 2023-08-17
ER

PT J
AU Kirkpatrick, A
   Vincent, AS
   Ross, ED
   Guthery, L
   Prodan, CI
AF Kirkpatrick, Angelia
   Vincent, Andrea S.
   Ross, Elliott D.
   Guthery, Leslie
   Prodan, Calin I.
TI Early Intervention in Vascular Mild Cognitive Impairment Improves
   Treatment of Vascular Risk Factors and Decreases Hospitalization Rates
SO STROKE
LA English
DT Meeting Abstract
CT American-Heart-Association/American-Stroke-Association International
   Stroke Conference / State-of-the-Science Stroke Nursing Symposium
CY JAN 24-26, 2018
CL Los Angeles, CA
SP Amer Stroke Assoc, Amer Heart Assoc
DE Adherence; Physician patient education; Quality improvement; Behavior
   change
FU American Heart Association, SouthWest - Arkansas; American Heart
   Association, SouthWest - Colorado; American Heart Association, SouthWest
   - New Mexico; American Heart Association, SouthWest - Oklahoma; American
   Heart Association, SouthWest - Texas; American Heart Association,
   SouthWest - Wyoming
FX This research has received full or partial funding support from the
   American Heart Association, SouthWest - Arkansas, Colorado, New Mexico,
   Oklahoma, Texas, Wyoming.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0039-2499
EI 1524-4628
J9 STROKE
JI Stroke
PD JAN
PY 2018
VL 49
SU 1
MA TMP93
PG 2
WC Clinical Neurology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA GC3ZX
UT WOS:000429723400088
DA 2023-08-17
ER

PT J
AU Booth, V
   Harwood, RH
   Hood-Moore, V
   Bramley, T
   Hancox, JE
   Robertson, K
   Hall, J
   Van Der Wardt, V
   Logan, PA
AF Booth, V.
   Harwood, R. H.
   Hood-Moore, V.
   Bramley, T.
   Hancox, J. E.
   Robertson, K.
   Hall, J.
   Van Der Wardt, V.
   Logan, P. A.
TI DEVELOPMENT OF THE PROMOTING ACTIVITY, INDEPENDENCE AND STABILITY IN
   EARLY DEMENTIA AND MILD COGNITIVE IMPAIRMENT (PrAISED) INTERVENTION
SO AGE AND AGEING
LA English
DT Meeting Abstract
C1 [Booth, V.; Harwood, R. H.; Hood-Moore, V.; Bramley, T.; Hancox, J. E.; Robertson, K.; Van Der Wardt, V.; Logan, P. A.] Univ Nottingham, Nottingham, England.
   [Booth, V.; Harwood, R. H.; Hall, J.] Nottingham Univ Hosp NHS Trust, Nottingham, England.
   [Bramley, T.] Nottinghamshire Healthcare NHS Fdn, Nottingham, England.
C3 University of Nottingham; Nottingham University Hospital NHS Trust
RI van der Wardt, Veronika/ABF-3836-2021; Hancox, Jennie/T-6596-2019
OI van der Wardt, Veronika/0000-0003-3995-7056; 
CR [Anonymous], 2008, DEV EVALUATING COMPL
   Delbaere K, 2012, AM J GERIAT PSYCHIAT, V20, P845, DOI 10.1097/JGP.0b013e31824afbc4
   Farmer T, 2006, QUAL HEALTH RES, V16, P377, DOI 10.1177/1049732305285708
NR 3
TC 0
Z9 0
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-0729
EI 1468-2834
J9 AGE AGEING
JI Age Ageing
PD AUG
PY 2018
VL 47
SU 3
MA 34
DI 10.1093/ageing/afy124.14
PG 1
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GU6DE
UT WOS:000445394700034
OA Bronze
DA 2023-08-17
ER

PT J
AU Jung, AR
   Kim, D
   Park, EA
AF Jung, Ae-Ri
   Kim, Dasom
   Park, Eun-A
TI Cognitive Intervention Using Information and Communication Technology
   for Older Adults with Mild Cognitive Impairment: A Systematic Review and
   Meta-Analysis
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE systematic review; meta-analysis; cognitive dysfunction; dementia;
   cognitive aging; memory disorders; aged; technology; mobile health;
   virtual reality
ID CORTICAL THICKNESS; PHYSICAL-EXERCISE; SINGLE-BLIND; DEMENTIA; MEMORY;
   STIMULATION; PLASTICITY; OUTCOMES
AB Background: Outside activities have decreased due to the spread of the COVID-19 since 2019; therefore, the need for education using information and communication technology (ICT) for older adults with mild cognitive impairment (MCI) has increased. This study systematically evaluated the effects of cognitive enhancement interventions using ICT on older adults with MCI. Methods: Six electronic databases (CINAHL, Cochrane CENTRAL, EMBASE, PubMed, RISS, and KISS) were searched for relevant articles published from 25 January to 10 February, 2021. Results: As a result of the systematic literature review, 12 research papers were finally selected as the literature for quality evaluation, and 11 final papers were selected, excluding one in the quality evaluation. From the synthesis in this study, it was found that cognitive intervention using ICT showed a statistically significant positive effect on cognitive function when compared with various control groups (SMD = 0.4547; p < 0.001; 95% CI: 0.1980-0.7113). Conclusions: Through this study, cognitive intervention using ICT showed a small effect size for older adults with mild cognitive impairment, and statistically significant results were found.
C1 [Jung, Ae-Ri; Park, Eun-A] Bucheon Univ, Coll Nursing, Bucheon 14774, South Korea.
   [Kim, Dasom] Nowon Gu Publ Hlth Ctr, 437 Nohae Ro, Seoul 01689, South Korea.
RP Kim, D (corresponding author), Nowon Gu Publ Hlth Ctr, 437 Nohae Ro, Seoul 01689, South Korea.
EM dudurdaram@naver.com
OI Kim, Dasom/0000-0003-4029-0877
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2021
VL 18
IS 21
AR 11535
DI 10.3390/ijerph182111535
PG 18
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA WX3LC
UT WOS:000718500600001
PM 34770049
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Coe, A
   Stapleton, T
   Martin, M
AF Coe, Aine
   Stapleton, Tadhg
   Martin, Mary
TI OUTCOMES OF A MEMORY STRATEGY EDUCATION GROUP INTERVENTION FOR CLIENTS
   WITH MILD COGNITIVE IMPAIRMENT AND EARLY DEMENTIA
SO AGE AND AGEING
LA English
DT Meeting Abstract
C1 [Coe, Aine; Stapleton, Tadhg] Trinity Coll Dublin, Dublin, Ireland.
   [Martin, Mary] Naas Gen Hosp, Naas, Kildare, Ireland.
C3 CHARMEU; Trinity College Dublin
RI Stapleton, Tadhg/G-4181-2017
OI Stapleton, Tadhg/0000-0001-9139-6060
NR 0
TC 0
Z9 0
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-0729
EI 1468-2834
J9 AGE AGEING
JI Age Ageing
PD SEP
PY 2016
VL 45
SU 2
MA 044
BP 2
EP 2
PG 1
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DY4ZW
UT WOS:000385109600008
DA 2023-08-17
ER

PT J
AU Belleville, S
   Gilbert, B
   Fontaine, F
   Gagnon, L
   Menard, E
   Gauthier, S
AF Belleville, Sylvie
   Gilbert, Brigitte
   Fontaine, Francine
   Gagnon, Lise
   Menard, Edith
   Gauthier, Serge
TI Improvement of episodic memory in persons with mild cognitive impairment
   and healthy older adults: Evidence from a cognitive intervention program
SO DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
LA English
DT Review
DE cognitive intervention; memory training; mild cognitive impairment;
   episodic memory; Alzheimer's disease; normal aging
ID ALZHEIMERS-DISEASE; DEMENTIA; PREDICTORS; TASK; AD
AB The efficacy of cognitive training was assessed in persons with mild cognitive impairment (MCI) and persons with normal cognitive aging. Forty-seven participants were included in this study: 28 with MCI and 17 controls. Twenty-one participants received intervention ( 20 MCI and 9 controls) and 16 participants ( 8 MCI and 8 controls) received no intervention (waiting-list group). The intervention focused on teaching episodic memory strategies. Three tasks of episodic memory ( list recall, face-name association, text memory) were used as primary outcome measures. Results were analyzed using analyses of variance. The intervention effect (pre- and post-intervention difference) was significant on two of the primary outcome measures ( delayed list recall and face-name association). A significant pre- post-effect was also found on measures of subjective memory and wellbeing. There was no improvement in the performance of groups of individuals with MCI and normal elderly persons who did not receive the intervention. These results suggest that persons with MCI can improve their performance on episodic memory when provided with cognitive training. Copyright (C) 2006 S. Karger AG, Basel.
C1 Inst Univ Geriatrie Montreal, Res Ctr, Montreal, PQ H3W 1W5, Canada.
   Univ Montreal, Dept Psychol, Ctr Rech Neuropsychol & Cognit, Montreal, PQ H3C 3J7, Canada.
   Inst Univ Geriatrie Sherbrooke, Res Ctr, Sherbrooke, PQ, Canada.
   McGill Ctr Studies Aging, Alzheimer & Related Disorders Clin, Verdun, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; University of
   Sherbrooke; McGill University
RP Belleville, S (corresponding author), Inst Univ Geriatrie Montreal, Res Ctr, 4565 Queen Mary, Montreal, PQ H3W 1W5, Canada.
EM sylvie.belleville@umontreal.ca
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NR 63
TC 249
Z9 269
U1 3
U2 54
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-8008
EI 1421-9824
J9 DEMENT GERIATR COGN
JI Dement. Geriatr. Cogn. Disord.
PY 2006
VL 22
IS 5-6
BP 486
EP 499
DI 10.1159/000096316
PG 14
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA 107JS
UT WOS:000242167600015
PM 17050952
DA 2023-08-17
ER

PT J
AU Vlachos, GS
   Scarmeas, N
AF Vlachos, George S.
   Scarmeas, Nikolaos
TI Dietary interventions in mild cognitive impairment and dementia
SO DIALOGUES IN CLINICAL NEUROSCIENCE
LA English
DT Article
DE Alzheimer disease; controlled clinical trial; diet; mild cognitive
   impairment; nutrition; treatment
ID PLACEBO-CONTROLLED TRIAL; ACETYL-L-CARNITINE; BODY-MASS INDEX;
   QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; DOUBLE-BLIND; MEDITERRANEAN DIET;
   ACID SUPPLEMENTATION; VITAMIN-E; CHOLINESTERASE-INHIBITORS
AB Dietary intervention is an enticing approach in the fight against cognitive impairment. Nutritional supplements and dietetic counseling are relatively easy and benign interventions, but research has not yet yielded irrefutable evidence as to their clinical utility. Heterogeneity in the results of available clinical studies, as well as methodological and practical issues, does not allow replication and generalization of findings. The paper at hand reviews only randomized clinical trials of single nutrients, multi-nutrient formulations and dietary counseling in mild cognitive impairment and dementia of the Alzheimer's type focusing on both cognitive and functional outcomes. Thus far, folate, vitamin E, Omega-3 fatty acids, and certain multi-nutrient formulations have shown some preliminary promising results; larger, well-designed trials are needed to confirm these findings before nutritional elements can be incorporated in recommended clinical guidelines. (C) 2019. AICH-Servier Group
C1 [Vlachos, George S.; Scarmeas, Nikolaos] Natl & Kapodistrian Univ Athens, Med Sch, Dept Neurol 1, Aiginit Hosp, Athens, Greece.
   [Scarmeas, Nikolaos] Columbia Univ, Dept Neurol, Gertrude B Sergievsky Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA.
C3 CIVIS; National & Kapodistrian University of Athens; Columbia University
RP Scarmeas, N (corresponding author), Aiginit Hosp, 72 Vassilissis Sofias Ave, Athens 11528, Greece.
EM ns257@columbia.edu
RI Scarmeas, Nikolaos/AAD-2517-2020; Scarmeas, Nikolaos/AAD-2512-2020
OI Scarmeas, Nikolaos/0000-0001-6453-8908; Scarmeas,
   Nikolaos/0000-0001-6453-8908; Vlachos, George/0000-0002-0757-2808
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NR 54
TC 30
Z9 32
U1 3
U2 18
PU INST CONFERENCE HIPPOCRATE
PI SURESNESS-CEDEX
PA 50 RUE CARNOT, SURESNESS-CEDEX, 92284, FRANCE
SN 1294-8322
EI 1958-5969
J9 DIALOGUES CLIN NEURO
JI Dialogues Clin. Neurosci.
PD MAR
PY 2019
VL 21
IS 1
BP 69
EP 82
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA HR1RY
UT WOS:000462913500009
PM 31607782
DA 2023-08-17
ER

PT J
AU Rodakowski, J
   Saghafi, E
   Butters, MA
   Skidmore, ER
AF Rodakowski, Juleen
   Saghafi, Ester
   Butters, Meryl A.
   Skidmore, Elizabeth R.
TI Non-pharmacological interventions for adults with mild cognitive
   impairment and early stage dementia: An updated scoping review
SO MOLECULAR ASPECTS OF MEDICINE
LA English
DT Review
DE Mild cognitive impairment; Dementia; Alzheimer's disease; Cognitive
   rehabilitation; Non-pharmacological interventions; Behavioral
   interventions
ID RANDOMIZED CONTROLLED-TRIAL; HEALTHY OLDER-ADULTS; ALZHEIMERS-DISEASE;
   NEUROPSYCHIATRIC SYMPTOMS; WORKING GROUP; MEMORY; REHABILITATION;
   PEOPLE; MCI; EXERCISE
AB The purpose of this scoping review was to examine the science related to non-pharmacological interventions designed to-slow decline for older adults with Mild Cognitive Impairment or early-stage dementia. We reviewed 32 unique randomized controlled trials that employed cognitive training (remediation or compensation approaches), physical exercise, or psychotherapeutic interventions that were published before November 2014. Evidence suggests that cognitive training focused on remediation and physical exercise interventions may promote small improvements in selected cognitive abilities. Cognitive training focused on compensation interventions and selected psychotherapeutic interventions may influence how cognitive changes impact daily living. However, confidence in these findings is limited due to methodological limitations. To better assess the value of non-pharmacological interventions for this population, we recommend: (1) adoption of universal criteria for "early stage cognitive decline" among studies, (2) adherence to guidelines for the conceptualization, operationalization, and implementation of complex interventions, (3) consistent characterization of the impact of interventions on daily life, and (4) long-term follow-up of clinical outcomes to assess maintenance and meaningfulness of reported effects over time. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Rodakowski, Juleen; Skidmore, Elizabeth R.] Univ Pittsburgh Rodakowski Skidmore, Dept Occupat Therapy, Sch Hlth & Rehabil Sci, Pittsburgh, PA USA.
   [Rodakowski, Juleen; Skidmore, Elizabeth R.] Univ Pittsburgh, Clin & Translat Sci Inst, Pittsburgh, PA 15260 USA.
   [Saghafi, Ester] Univ Pittsburgh Saghafi, Hlth Sci Lib Syst, Pittsburgh, PA USA.
   [Butters, Meryl A.] Univ Pittsburgh Butters, Dept Psychiat Sch Med, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Skidmore, ER (corresponding author), Univ Pittsburgh, Dept Occupat Therapy, 5012 Forbes Tower, Pittsburgh, PA 15260 USA.
EM skidmore@pitt.edu
RI Rodakowski, Juleen/J-3536-2019; Butters, Meryl/AAR-2863-2021
OI Rodakowski, Juleen/0000-0002-6397-8124; 
FU National Institutes of Health [KL2TR000146, P30 MH090333, 8315, UL1
   TR000005]
FX This work was supported by the National Institutes of Health grants
   KL2TR000146, P30 MH090333, P30 MH090333 Sub-project ID: 8315, and UL1
   TR000005.
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NR 81
TC 105
Z9 116
U1 3
U2 78
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0098-2997
EI 1872-9452
J9 MOL ASPECTS MED
JI Mol. Asp. Med.
PD JUN-OCT
PY 2015
VL 43-44
SI SI
BP 38
EP 53
DI 10.1016/j.mam.2015.06.003
PG 16
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA CV4VC
UT WOS:000364263600005
PM 26070444
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Uemura, K
   Shimada, H
   Makizako, H
   Doi, T
   Yoshida, D
   Tsutsumimoto, K
   Anan, Y
   Suzuki, T
AF Uemura, Kazuki
   Shimada, Hiroyuki
   Makizako, Hyuma
   Doi, Takehiko
   Yoshida, Daisuke
   Tsutsumimoto, Kota
   Anan, Yuya
   Suzuki, Takao
TI Cognitive function affects trainability for physical performance in
   exercise intervention among older adults with mild cognitive impairment
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE exercise; mobility; rehabilitation; Timed Up and Go test
ID MINI-MENTAL-STATE; USUAL GAIT SPEED; LIFE-SPACE; MOBILITY; DECLINE;
   BALANCE; RISK; GO; ADHERENCE; FALLS
AB Background: Although much evidence supports the hypothesis that cognitive function and physical function are interrelated, it is unclear whether cognitive decline with mild cognitive impairment influences trainability of physical performance in exercise intervention. The purpose of this study was to examine the association between cognitive function at baseline and change in physical performance after exercise intervention in older adults with mild cognitive impairment.
   Methods: Forty-four older adults diagnosed with mild cognitive impairment based on the Peterson criteria (mean age 74.8 years) consented to and completed a 6-month twice weekly exercise intervention. The Timed Up and Go (TUG) test was used as a measure of physical performance. The Mini-Mental State Examination (MMSE), Trail Making Test Part B, Geriatric Depression Scale, baseline muscle strength of knee extension, and attendance rate of intervention, were measured as factors for predicting trainability.
   Results: In the correlation analysis, the change in TUG showed modest correlations with attendance rate in the exercise program (r = -0.354, P = 0.027) and MMSE at baseline (r = -0.321, P = 0.034). A multiple regression analysis revealed that change in TUG was independently associated with attendance rate (beta = -0.322, P = 0.026) and MMSE score (beta = -0.295, P = 0.041), controlling for age and gender.
   Conclusion: General cognitive function was associated with improvements in physical performance after exercise intervention in subjects with mild cognitive impairment. Further research is needed to examine the effects of exercise programs designed to address cognitive obstacles in older adults with mild cognitive impairment.
C1 [Uemura, Kazuki; Shimada, Hiroyuki; Makizako, Hyuma; Doi, Takehiko; Yoshida, Daisuke; Tsutsumimoto, Kota; Anan, Yuya] Natl Ctr Geriatr & Gerontol, Ctr Gerontol & Social Sci, Dept Res & Dev Support Independent Life Elderly, Sect Hlth Promot, Obu, Aichi 4748511, Japan.
   [Suzuki, Takao] Natl Ctr Geriatr & Gerontol, Res Inst, Obu, Aichi 4748511, Japan.
   [Uemura, Kazuki; Makizako, Hyuma] Japan Soc Promot Sci, Tokyo, Japan.
C3 National Center for Geriatrics & Gerontology; National Center for
   Geriatrics & Gerontology; Japan Society for the Promotion of Science
RP Uemura, K (corresponding author), Natl Ctr Geriatr & Gerontol, Ctr Gerontol & Social Sci, Dept Res & Dev Support Independent Life Elderly, Sect Hlth Promot, 35 Gengo Morioka, Obu, Aichi 4748511, Japan.
EM uemura@ncgg.go.jp
RI Uemura, Kazuki/AAU-3382-2020
OI Uemura, Kazuki/0000-0003-1101-3424; Shimada,
   Hiroyuki/0000-0001-8111-6440
FU Japanese Ministry of Health, Labour, and Welfare [B-3]; Grants-in-Aid
   for Scientific Research [11J02998] Funding Source: KAKEN
FX We would like to thank the Obu City Office for assisting with
   recruitment of participants, and the speech therapists of the Ukai
   Rehabilitation Hospital for their assistance with data collection. This
   work was supported by a grant from the Japanese Ministry of Health,
   Labour, and Welfare (programs minimizing long-term care B-3, to TS).
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NR 31
TC 30
Z9 33
U1 1
U2 37
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2013
VL 8
BP 97
EP 102
DI 10.2147/CIA.S39434
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 081AO
UT WOS:000314286700001
PM 23390362
OA Green Submitted, Green Published, gold
DA 2023-08-17
ER

PT J
AU Shim, M
   Tilley, JL
   Im, S
   Price, K
   Gonzalez, A
AF Shim, Minjung
   Tilley, Jacqueline L.
   Im, Sungjin
   Price, Kevin
   Gonzalez, Adam
TI A Systematic Review of Mindfulness-Based Interventions for Patients with
   Mild Cognitive Impairment or Dementia and Caregivers
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Review
DE mindfulness-based interventions; dementia; caregiver burden; geriatric
   psychiatry; systematic review; mild cognitive impairment
ID RANDOMIZED CONTROLLED-TRIALS; FAMILY CAREGIVERS; ALZHEIMERS-DISEASE;
   STRESS REDUCTION; OLDER-ADULTS; AUTOBIOGRAPHICAL MEMORY; PSYCHOLOGICAL
   STRESS; INFORMAL CAREGIVERS; MENTAL-HEALTH; MEDITATION
AB The aim of this article was to systematically review the quality and efficacy of the current evidence for mindfulness-based interventions (MBIs) in patients with mild cognitive impairment (MCI), patients with dementia (PwD), and their caregivers. We identified 20 randomized controlled trials (RCTs) (11 for patients, 9 for caregivers) published in the last 15 years. Evidence suggested that MBIs are highly acceptable and credible treatments for patients with MCI, PwD and caregivers. Specifically, for PwD, the results indicated that the magnitude of post-treatment effects of MBIs are in the medium to large range for psychosocial outcomes, and in the small to medium range for cognitive functioning; however, treatment effects on dementia biomarkers were mixed, ranging from small to large, depending on the outcome measure. Findings also evidenced salutary effects of MBIs for caregivers of PwD, with post-treatment effects ranging from medium to large for caregiver stress and burden and large effects for quality of life, and mixed outcomes for cognitive functioning, with effects in the small to large range. However, confidence in these findings is relatively limited due to methodological limitations, especially in terms of poor consistency in intervention strategies, outcome measures, and other key criteria across studies. To better assess the value of MBIs for these populations and optimize treatment outcomes, we recommend further research with improved study methodology (e.g., multi-method assessment, universal criterion and outcome measures, use of active control groups, larger sample sizes, long-term follow-up) to replicate current findings and enhance our understanding of underlying treatment mechanisms of MBIs.
C1 [Shim, Minjung] Drexel Univ, Dept Creat Arts Therapies, 1601 Cherry St,Suite 7113, Philadelphia, PA 19102 USA.
   [Tilley, Jacqueline L.; Price, Kevin; Gonzalez, Adam] SUNY Stony Brook, Dept Psychiat & Behav Hlth, Stony Brook, NY 11794 USA.
   [Im, Sungjin] Western Kentucky Univ, Dept Psychol, Bowling Green, KY 42101 USA.
C3 Drexel University; State University of New York (SUNY) System; State
   University of New York (SUNY) Stony Brook; Western Kentucky University
RP Shim, M (corresponding author), Drexel Univ, Dept Creat Arts Therapies, 1601 Cherry St,Suite 7113, Philadelphia, PA 19102 USA.
EM Ms344@drexel.edu
RI Tilley, Jacqueline/ABA-1233-2021; Tilley, Jacqueline/AFU-5911-2022
OI Tilley, Jacqueline/0000-0002-2701-5064; Im, Sungjin/0000-0001-9272-8346;
   shim, minjung/0000-0003-0277-6497
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NR 106
TC 21
Z9 22
U1 4
U2 26
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
EI 1552-5708
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD NOV
PY 2021
VL 34
IS 6
SI SI
BP 528
EP 554
AR 0891988720957104
DI 10.1177/0891988720957104
EA SEP 2020
PG 27
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA WZ4KM
UT WOS:000571052300001
PM 32935611
DA 2023-08-17
ER

PT J
AU Kim, J
   Cuevas, H
   Wood, ST
AF Kim, Jeeyeon
   Cuevas, Heather
   Wood, Shenell Tiara
TI Effect of Music Interventions on Cognitive Function in Older Adults With
   Mild Cognitive Impairment A Systematic Review
SO RESEARCH IN GERONTOLOGICAL NURSING
LA English
DT Review; Early Access
ID DEMENTIA; CONNECTIVITY; DYSFUNCTION; PROGRESSION
AB The purpose of the current systematic review was to examine the effects of music interventions on cognitive function in older adults with mild cognitive impairment (MCI). A systematic search of CINAHL, PubMed, PsycINFO, and Web of Science databases was performed. Studies examining the effects of music interventions on cognitive function in older adults with MCI were included. Narrative synthesis for cognitive outcomes postintervention was performed. A total of 11 articles met inclusion criteria. Music interventions significantly improved global cognitive function, verbal fluency, executive function, and spatial function in older adults with MCI. Included studies were heterogeneous in terms of the type of intervention, cognitive assessment tool, and intervention duration. Six studies were at risk of bias due to missing data and confounding factors. Our findings suggest that music interventions can be an effective strategy to improve cognitive function for older adults with MCI. However, findings should be interpreted with caution. More rigorous studies with various types of music interventions investigating cognitive domain-specific effects are needed. [Research in Gerontological Nursing, xx(x), xx-xx.]
C1 [Kim, Jeeyeon; Cuevas, Heather; Wood, Shenell Tiara] Univ Texas Austin, Sch Nursing, Austin, TX USA.
   [Kim, Jeeyeon] Univ Texas Austin, Sch Nursing, 1710 Red River St, Austin, TX 78712 USA.
C3 University of Texas System; University of Texas Austin; University of
   Texas System; University of Texas Austin
RP Kim, J (corresponding author), Univ Texas Austin, Sch Nursing, 1710 Red River St, Austin, TX 78712 USA.
EM jeeyeonkim@utexas.edu
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NR 55
TC 0
Z9 0
U1 1
U2 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 1940-4921
EI 1938-2464
J9 RES GERONTOL NURS
JI Res. Gerontol. Nurs.
PD 2023 JUN 16
PY 2023
DI 10.3928/19404921-20230609-01
EA JUN 2023
PG 16
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA K3BH7
UT WOS:001015220000001
PM 37335894
DA 2023-08-17
ER

PT J
AU LIN, R
   LUO, YT
   YAN, YJ
   HUANG, CS
   CHEN, LL
   CHEN, MF
   LIN, MJ
   LI, H
AF LIN, R. O. N. G.
   LUO, YU-TING
   YAN, YUAN-JIAO
   HUANG, CHEN-SHAN
   CHEN, LI-LI
   CHEN, MING-FENG
   LIN, MO-JUN
   LI, H. O. N. G.
TI Effects of an art-based intervention in older adults with mild cognitive
   impairment: a randomised controlled trial
SO AGE AND AGEING
LA English
DT Article
DE art; mild cognitive impairment; non-pharmacological intervention;
   prevention; randomised controlled trial; storytelling; older people
ID CREATIVE EXPRESSION THERAPY; ALZHEIMERS-DISEASE; DEMENTIA; QUALITY;
   RISK; LIFE
AB Background Art-based interventions may delay cognitive decline and improve health-related outcomes in older adults with mild cognitive impairment (MCI). Objective To examine the effects of the Creative Expressive Arts-based Storytelling (CrEAS) program compared to active and waitlist controls on neurocognitive and other health-related outcomes in older people with MCI. Design Three-arm parallel-group, randomised controlled design. Participants One-hundred and thirty-five adults with MCI (mean age: 70.93 +/- 6.91 years). Methods Participants were randomly assigned to intervention (CrEAS, n = 45), active control (n = 45) or waitlist control (n = 45) groups. Interventions were applied once per week for 24 weeks. The primary outcome was global cognitive function; secondary outcomes were specific cognition domains (memory, executive function, language and attention) and other health-related outcomes (anxiety, depression and quality of life [QoL]). All variables were measured at baseline (T0), 24-week follow-up (T1) and 48-week follow-up (T2). Results Participants in the CrEAS group showed significantly higher global cognitive function (adjusted mean difference [MD] = -0.905, 95% confidence interval [CI] -1.748 to -0.062; P = 0.038) and QoL (adjusted MD = -4.150, 95% CI -6.447 to -1.853; P = 0.001) and lower depression symptoms (adjusted MD = 2.902, 95% CI 0.699-5.104; P = 0.011) post-intervention at the 24-week follow-up compared with the active control group. At 48-week follow-up, only the Auditory Verbal Learning Test Immediate recall score was significantly improved compared with the active control group (adjusted MD = -2.941, 95% CI -5.262 to -0.620; P = 0.014). Conclusions Older adults with MCI who participated in the CrEAS program improved their neuropsychological outcomes and QoL and reduced their rate of cognitive deterioration.
C1 [LIN, R. O. N. G.; CHEN, LI-LI; LI, H. O. N. G.] Fujian Med Univ, Fujian Provincial Hosp, Res Ctr Nursing Theory & Practice, Shengli Clin Med Coll, Fuzhou, Peoples R China.
   [LIN, R. O. N. G.; LUO, YU-TING; YAN, YUAN-JIAO; HUANG, CHEN-SHAN; CHEN, LI-LI; LI, H. O. N. G.] Fujian Med Univ, Sch Nursing, Fuzhou, Peoples R China.
   [CHEN, MING-FENG] Fujian Provincial Hosp, Neurol Dept, Fuzhou, Peoples R China.
   [LIN, MO-JUN] Fujian Med Univ, Sch Basic Med, Fuzhou, Peoples R China.
C3 Fujian Medical University; Fujian Provincial Hospital; Fujian Medical
   University; Fujian Provincial Hospital; Fujian Medical University
RP LI, H (corresponding author), Fujian Provincial Hosp, Res Ctr Nursing Theory & Practice, 134 East Str, Fuzhou, Fujian, Peoples R China.; LIN, MJ (corresponding author), Fujian Med Univ, Sch Basic Med Sci, 1XueYuan Road,Univ Town, Fuzhou, Fujian, Peoples R China.
EM mjlin@mail.fjmu.edu.cn; ydluoyt@126.com; yuanjiao1994@126.com;
   610706089@qq.com; 13799422295@139.com; mjlin@mail.fjmu.edu.cn;
   leehong99@126.com
RI Chen, Lili/HDO-4932-2022
OI Chen, Lili/0000-0003-3844-4320
FU National Natural Science Foundation of China [82071222]; Startup Fund
   for Scientific Research, Fujian Medical University, China [2018QH2023];
   Joint Funds for the Innovation of Science and Technology, Fujian
   Province [2020Y9021]
FX This study was funded by the National Natural Science Foundation of
   China (82071222); Startup Fund for Scientific Research, Fujian Medical
   University, China (2018QH2023); Joint Funds for the Innovation of
   Science and Technology, Fujian Province (Grant number: 2020Y9021). In
   this study, research funding was mainly used for data collection,
   material purchase, data analysis and labour fees.
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NR 42
TC 1
Z9 1
U1 11
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-0729
EI 1468-2834
J9 AGE AGEING
JI Age Ageing
PD JUL 1
PY 2022
VL 51
IS 7
AR afac144
DI 10.1093/ageing/afac144
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 3D7YJ
UT WOS:000829513300004
PM 35871420
DA 2023-08-17
ER

PT J
AU Fink, HA
   Jutkowitz, E
   McCarten, JR
   Hemmy, LS
   Butler, M
   Davila, H
   Ratner, E
   Calvert, C
   Barclay, TR
   Brasure, M
   Nelson, VA
   Kane, RL
AF Fink, Howard A.
   Jutkowitz, Eric
   McCarten, J. Riley
   Hemmy, Laura S.
   Butler, Mary
   Davila, Heather
   Ratner, Edward
   Calvert, Collin
   Barclay, Terry R.
   Brasure, Michelle
   Nelson, Victoria A.
   Kane, Robert L.
TI Pharmacologic Interventions to Prevent Cognitive Decline, Mild Cognitive
   Impairment, and Clinical Alzheimer-Type Dementia A Systematic Review
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Review
ID QUALITY-OF-LIFE; POSTMENOPAUSAL HORMONE-THERAPY; ESTROGEN PLUS
   PROGESTIN; CONJUGATED EQUINE ESTROGENS; ISOLATED SYSTOLIC HYPERTENSION;
   HEALTH INITIATIVE MEMORY; PLACEBO-CONTROLLED TRIAL; WOMENS HEALTH;
   DOUBLE-BLIND; RANDOMIZED-TRIAL
AB Background: Optimal treatment to prevent or delay cognitive decline, mild cognitive impairment (MCI), or dementia is uncertain.
   Purpose: To summarize current evidence on the efficacy and harms of pharmacologic interventions to prevent or delay cognitive decline, MCI, or dementia in adults with normal cognition or MCI.
   Data Sources: Several electronic databases from January 2009 to July 2017, bibliographies, and expert recommendations.
   Study Selection: English-language trials of at least 6 months' duration enrolling adults without dementia and comparing pharmacologic interventions with placebo, usual care, or active control on cognitive outcomes.
   Data Extraction: Two reviewers independently rated risk of bias and strength of evidence; 1 extracted data, and a second checked accuracy.
   Data Synthesis: Fifty-one unique trials were rated as having low to moderate risk of bias (including 3 that studied dementia medications, 16 antihypertensives, 4 diabetes medications, 2 nonsteroidal anti-inflammatory drugs [NSAIDs] or aspirin, 17 hormones, and 7 lipid-lowering agents). In persons with normal cognition, estrogen and estrogen-progestin increased risk for dementia or a combined outcome of MCI or dementia (1 trial, low strength of evidence); high-dose raloxifene decreased risk for MCI but not for dementia (1 trial, low strength of evidence); and antihypertensives (4 trials), NSAIDs (1 trial), and statins (1 trial) did not alter dementia risk (low to insufficient strength of evidence). In persons with MCI, cholinesterase inhibitors did not reduce dementia risk (1 trial, low strength of evidence). In persons with normal cognition and those with MCI, these pharmacologic treatments neither improved nor slowed decline in cognitive test performance (low to insufficient strength of evidence). Adverse events were inconsistently reported but were increased for estrogen (stroke), estrogen-progestin (stroke, coronary heart disease, invasive breast cancer, and pulmonary embolism), and raloxifene (venous thromboembolism).
   Limitation: High attrition, short follow-up, inconsistent cognitive outcomes, and possible selective reporting and publication.
   Conclusion: Evidence does not support use of the studied pharmacologic treatments for cognitive protection in persons with normal cognition or MCI.
C1 Minneapolis VA Hlth Care Syst, Minneapolis, MN USA.
   [Butler, Mary; Davila, Heather; Brasure, Michelle; Nelson, Victoria A.] Univ Minnesota, Div Hlth Policy & Management, 420 Delaware St Southeast,Mayo Mem Bldg D351, Minneapolis, MN 55455 USA.
   [Calvert, Collin] Univ Minnesota, Div Epidemiol, 1300 South 2nd St,Room 300,West Bank Off Bldg, Minneapolis, MN 55455 USA.
   [Jutkowitz, Eric] Brown Univ, Sch Publ Hlth, Box G S121-6,121 South Main St,6th Floor, Providence, RI 02912 USA.
   HealthPartners, Minneapolis, MN USA.
   [Fink, Howard A.; McCarten, J. Riley; Hemmy, Laura S.; Ratner, Edward] VA Hlth Care Syst, Geriatr Res Educ & Clin Ctr, One Vet Dr,11-G, Minneapolis, MN 55417 USA.
   [Barclay, Terry R.] Univ Minnesota, Dept Neurol, 295 Phalen Blvd,Mailstop 41203C, St Paul, MN 55130 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Minneapolis VA Health Care System; University of Minnesota System;
   University of Minnesota Twin Cities; University of Minnesota System;
   University of Minnesota Twin Cities; Brown University; Geriatric
   Research Education & Clinical Center; University of Minnesota System;
   University of Minnesota Twin Cities
RP Fink, HA (corresponding author), VA Hlth Care Syst, One Vet Dr,11-G, Minneapolis, MN 55417 USA.
EM Howard.fink@va.gov
RI Fink, Howard A/F-3933-2012; Calvert, Collin/IZQ-5088-2023
OI , Collin/0000-0003-1834-5245; Davila, Heather/0000-0003-1832-7901
FU AHRQ [290-2015-00008-I]
FX This manuscript is based on research conducted by the Minnesota
   Evidence-based Practice Center under AHRQ contract 290-2015-00008-I.
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NR 121
TC 107
Z9 114
U1 0
U2 52
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572,
   UNITED STATES
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD JAN 2
PY 2018
VL 168
IS 1
BP 39
EP +
DI 10.7326/M17-1529
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FR5SO
UT WOS:000419126700006
PM 29255847
DA 2023-08-17
ER

PT J
AU Vidovich, MR
   Lautenschlager, NT
   Flicker, L
   Clare, L
   Almeida, OP
AF Vidovich, Mandy R.
   Lautenschlager, Nicola T.
   Flicker, Leon
   Clare, Linda
   Almeida, Osvaldo P.
TI Treatment fidelity and acceptability of a cognition-focused intervention
   for older adults with mild cognitive impairment (MCI)
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE acceptability; fidelity; cognitive activity; mild cognitive impairment
ID BEHAVIORAL INTERVENTIONS
AB Background: Acceptability and fidelity assessments are an integral part of research, although few published trials comment on these processes in detail.
   Methods: We designed a randomized controlled trial (RCT) to identify the benefits of a cognition-focused intervention for older adults with mild cognitive impairment. Participants completed a six-item feedback questionnaire identifying level of satisfaction with their allocated intervention; this formed the acceptability assessment. Audio recordings of all sessions were reviewed and systematically assessed and rated for consistency of delivery (fidelity assessment).
   Results: Mean attendance (standard deviation) was 8.1 sessions (2.8) for the cognitive activity (CA) group and 8.4 (2.6) for the control general education group. There were no differences between groups regarding clarity and interest, willingness to attend the program in the community and pay a fee. Both groups reported the interventions to be relevant to their needs; however, this was rated more highly by the CA group (p < 0.01). There was high adherence to delivery of program content across both groups, yielding consistency scores above 95%.
   Conclusion: This study illustrates a systematic approach to assess acceptability and fidelity. The results show that the intervention was well received and met the needs of all participants. The manualized structure of the sessions facilitated the systematic implementation and reproducibility of the interventions. Acceptability and fidelity assessments have implications for the validity of assumptions made regarding trial outcomes and should therefore be included as standard process in RCTs.
C1 [Vidovich, Mandy R.; Lautenschlager, Nicola T.; Flicker, Leon; Almeida, Osvaldo P.] Univ Western Australia, Western Australian Inst Med Res, CMR, Western Australia Ctr Hlth & Ageing, Perth, WA 6009, Australia.
   [Lautenschlager, Nicola T.; Almeida, Osvaldo P.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia.
   [Lautenschlager, Nicola T.] Univ Melbourne, Dept Psychiat, St Vincents Hlth, Acad Unit Psychiat Old Age, Melbourne, Vic, Australia.
   [Clare, Linda] Bangor Univ, Sch Psychol, Bangor, Gwynedd, Wales.
   [Almeida, Osvaldo P.] Royal Perth Hosp, Dept Psychiat, Perth, WA, Australia.
C3 University of Western Australia; University of Western Australia;
   University of Melbourne; Bangor University; Royal Perth Hospital;
   University of Western Australia
RP Vidovich, MR (corresponding author), Univ Western Australia, WA Ctr Hlth & Ageing M573, 35 Stirling Highway, Perth, WA 6009, Australia.
EM mandy.vidovich@uwa.edu.au
RI Flicker, Leon/AAE-1530-2022; Almeida, Osvaldo P./A-4925-2008
OI Flicker, Leon/0000-0002-3650-0475; Almeida, Osvaldo
   P./0000-0002-8689-6199; Clare, Linda/0000-0003-3989-5318;
   Lautenschlager, Nicola/0000-0003-4850-7794
FU Centre of Excellence in Alzheimer's Disease Research and Care [L0602];
   National Health and Medical Research Council [513772]
FX We are most grateful to all volunteers taking part in the study and to
   our research staff. This project is supported by grants from the Centre
   of Excellence in Alzheimer's Disease Research and Care (L0602) and the
   National Health and Medical Research Council (513772).
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NR 10
TC 9
Z9 9
U1 1
U2 10
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD MAY
PY 2013
VL 25
IS 5
BP 815
EP 823
DI 10.1017/S1041610212002402
PG 9
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 114SD
UT WOS:000316761800013
PM 23425352
DA 2023-08-17
ER

PT J
AU Jordan, C
   Lawlor, B
   Loughrey, D
AF Jordan, Catherine
   Lawlor, Brian
   Loughrey, David
TI A systematic review of music interventions for the cognitive and
   behavioural symptoms of mild cognitive impairment (non-dementia)
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Review
DE Music interventions; Behavioural symptoms; Cognitive symptoms; Mild
   cognitive impairment
ID ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; DEPRESSIVE SYMPTOMS;
   THERAPY; PREVENTION; PROGRESSION; PREDICTORS; ANXIETY; MEMORY; ADULTS
AB Music interventions may represent an effective approach to improving symptoms and delaying progression of MCI to dementia. This review identified nine studies (8 RCT's, 1 observational study) that explored the benefits of music interventions to those with MCI. Studies included five music-playing interventions (sample size (n) ranged from 35 to 201, age ranged from 62 to 94), one music listening intervention (n = 100, mean age = 77 (music intervention) mean age = 76 (dance intervention), one music with movement intervention (n = 16, age range 65-84 years) and two music reminiscence interventions (n = 68; 72, age range = 60-85 years). Only individuals with a clinical diagnosis of MCI were included, no individuals with a diagnosis of dementia were included. Studies were limited due to their sample size, failure to consider confounding variables (i.e. socialization), inconsistency with therapist led sessions, failure to match conditions across interventions, limited followup period post-intervention and the tendency to focus on depression exclusively as a measure of behavioural symptoms. Different types of music interventions have differential results on cognitive and behavioural symptoms. The different pattern of brain activation and cognitive abilities which support each type of music activity (e.g. listening vs playing music) may offer some explanation towards these differences. A standardised protocol is needed for each type of music intervention to address how music interventions are studied, taking these limitations into consideration.
C1 [Jordan, Catherine; Lawlor, Brian; Loughrey, David] Global Brain Hlth Inst, Trinity Coll Dublin, Dublin, Ireland.
C3 Trinity College Dublin
RP Jordan, C (corresponding author), Global Brain Hlth Inst, Trinity Coll Dublin, Dublin, Ireland.
EM catherine.jordan@gbhi.org
FU Alzheimer's Association; Alzheimer's Society [GBHI ALZ UK-19-591069];
   GBHI
FX Dr Catherine Jordan is an Atlantic Fellow for Equity in brain Health at
   the Global Brain Health Institute (GBHI) and is supported with funding
   from GBHI, Alzheimer's Association, and Alzheimer's Society (GBHI ALZ
   UK-19-591069).
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NR 49
TC 3
Z9 4
U1 8
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JUL
PY 2022
VL 151
BP 382
EP 390
DI 10.1016/j.jpsychires.2022.04.028
EA MAY 2022
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 2A7SF
UT WOS:000809696400001
PM 35576664
OA hybrid
DA 2023-08-17
ER

PT J
AU Chen, HL
   Xiao, M
   Lin, YR
   Hamalainen, J
   Hagedon, A
   Yin, Y
AF Chen, Honglin
   Xiao, Meng
   Lin, Yiran
   Hamalainen, Juha
   Hagedon, Aaron
   Yin, You
TI Current development of a nonpharmacological intervention approach for
   mild cognitive impairment patients and a clinical trial in China
SO JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
LA English
DT Article
ID QUALITY
C1 [Chen, Honglin; Hamalainen, Juha] Univ Eastern Finland, Dept Social Sci, Kuopio 70150, Finland.
   [Chen, Honglin; Hamalainen, Juha] Fudan Univ, Sch Social Dev & Publ Policy, Shanghai 200433, Peoples R China.
   [Xiao, Meng] Tianjin Normal Univ, Tianjin 300387, Peoples R China.
   [Lin, Yiran] Nanjing Agr Univ, Fac Publ Adm, Nanjing 210095, Jiangsu, Peoples R China.
   [Hagedon, Aaron] Univ Texas Arlington, Sch Social Work, Arlington, TX 76019 USA.
   [Yin, You] Naval Med Univ, Affiliated Hosp 2, Changzheng Hosp, Dept Neurol, Shanghai 200003, Peoples R China.
C3 University of Eastern Finland; Fudan University; Tianjin Normal
   University; Nanjing Agricultural University; University of Texas System;
   University of Texas Arlington; Naval Medical University
RP Yin, Y (corresponding author), Navy Med Univ, Changzheng Hosp, Dept Neurol, 415 Fengyang Rd, Shanghai 200003, Peoples R China.
EM yinyou179@163.com
OI YIN, YOU/0000-0001-9657-9720
FU National Social Science Foundation project of China [21BSH130]; Science
   and Technology Support Projects in Biomedicine Field of Shanghai Science
   and Technology Commission
FX The work is supported by the National Social Science Foundation project
   of China (No. 21BSH130) and the funding of Science and Technology
   Support Projects in Biomedicine Field of Shanghai Science and Technology
   Commission.
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NR 18
TC 0
Z9 0
U1 2
U2 4
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 2450-131X
EI 2224-4018
J9 J TRANSL INTERN MED
JI J. TRANSL. INTERN. MED.
PD APR 2
PY 2022
VL 10
IS 1
BP 5
EP 8
DI 10.2478/jtim-2022-0007
EA APR 2022
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 0J0NT
UT WOS:000778658800001
PM 35702185
OA Green Published, hybrid
DA 2023-08-17
ER

PT J
AU Regan, B
   Varanelli, L
AF Regan, Bridget
   Varanelli, Laura
TI Adjustment, depression, and anxiety in mild cognitive impairment and
   early dementia: a systematic review of psychological intervention
   studies
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Review
DE MCI; dementia; psychosocial; interventions
ID ALZHEIMERS-DISEASE; PSYCHOSOCIAL INTERVENTION; MAJOR DEPRESSION; PEOPLE;
   PSYCHOTHERAPY; THERAPY; LIFE; MULTICENTER; OUTCOMES; QUALITY
AB Background: Many people with mild cognitive impairment (MCI) or early dementia suffer from concomitant depression and anxiety disorders, which in some cases, may be related difficulties adjusting to their diagnosis and associated cognitive problems. Successful adjustment and alleviation of depression and anxiety symptoms in these people is of critical importance for quality of life and may also help prevent, or delay, further cognitive decline. A variety of psychosocial intervention approaches has been trialed with this group.
   Method: The literature was systematically searched for community-based intervention studies that aim to improve depression, anxiety, or adjustment. Studies were included or excluded using a priori criteria. Once included, the quality of studies was evaluated using pre-set criteria.
   Results: Seventeen of 925 studies identified through literature databases and manual searches met the inclusion criteria. Of these, 16 were considered to be of at least "adequate quality." These included seven randomized controlled trials and eight pre-post studies. A diverse range of psychotherapeutic approaches, formats (individual or group), outcome measures, inclusion criteria, and cultural contexts were apparent, making comparisons between studies challenging.
   Conclusions: Several studies have demonstrated positive findings in the treatment of depression in older adults with early dementia using problem solving and modified cognitive behavior therapy (CBT) approaches. Amongst the large range of approaches trialed to improve adjustment and quality of life for patients with MCI and early dementia, some approaches, such as modified CBT, have shown promise. There is a need for replication studies using more rigorous methodology before clear clinical recommendations can be made.
C1 [Regan, Bridget; Varanelli, Laura] La Trobe Univ, Lincoln Ctr Res Ageing, Australian Inst Primary Care & Ageing, Bundoora, Vic 3086, Australia.
   [Regan, Bridget] Monash Univ, Monash Ageing Res Ctr MONARC, Clayton, Vic 3800, Australia.
C3 La Trobe University; Monash University
RP Regan, B (corresponding author), La Trobe Univ, Lincoln Ctr Res Ageing, Australian Inst Primary Care & Ageing, Plenty Rd, Bundoora, Vic 3086, Australia.
EM B.Regan@latrobe.edu.au
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NR 53
TC 39
Z9 40
U1 0
U2 72
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD DEC
PY 2013
VL 25
IS 12
BP 1963
EP 1984
DI 10.1017/S104161021300152X
PG 22
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 251NH
UT WOS:000326935600006
PM 24125507
DA 2023-08-17
ER

PT J
AU Forster, S
   Buschert, VC
   Buchholz, HG
   Teipel, SJ
   Friese, U
   Zach, C
   la Fougere, C
   Rominger, A
   Drzezga, A
   Hampel, H
   Bartenstein, P
   Buerger, K
AF Foerster, Stefan
   Buschert, Verena C.
   Buchholz, Hans-Georg
   Teipel, Stefan J.
   Friese, Uwe
   Zach, Christian
   la Fougere, Christian
   Rominger, Axel
   Drzezga, Alexander
   Hampel, Harald
   Bartenstein, Peter
   Buerger, Katharina
TI Effects of a 6-Month Cognitive Intervention Program on Brain Metabolism
   in Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Alzheimer's disease; cognitive intervention; cognitive stimulation;
   cognitive training; FDG PET; mild cognitive impairment
ID ANTERIOR CINGULATE CORTEX; GLOBAL MEAN NORMALIZATION; RATING-SCALE;
   FOLLOW-UP; FDG-PET; DEMENTIA; ACTIVATION; RESERVE
AB The effect of cognitive intervention on brain metabolism in Alzheimer's disease (AD) is largely unexplored. Therefore, we aimed to investigate clinical cognitive parameters and (18)FDG PET to test for effects of a cognitive intervention in patients with amnestic mild cognitive impairment (aMCI) or mild AD. Patients with aMCI (n = 24) or mild AD(n = 15) were randomly assigned either to cognitive intervention groups (IGs), receiving weekly sessions of group-based multicomponent cognitive intervention, or active control groups (CGs), receiving pencil-paper exercises for self-study. We obtained resting-state FDG-PET scans and neuropsychological testing at baseline and after six-months. Normalized FDG-PET images were analyzed using voxel-based SPM5 approaches to determine longitudinal changes, group-by-time interactions, and correlations with neuropsychological outcome parameters. Primary global cognitive outcome was determined by analyses of covariance with MMSE and ADAS-cog scores as dependent measures. Both, aMCI and AD subgroups of CGs showed widespread bilateral cortical declines in FDG uptake, while the AD subgroup of IGs showed discrete decline or rather no decline in case of the aMCI subgroup. Group by time analyses revealed strongest attenuation of metabolic decline in the aMCI subgroup of the IGs, involving left superior temporal-and anterior cingulate gyrus. However, correlation analyses revealed only weak non-significant associations betweenincreased FDG uptake and improvement in primary or secondary outcome parameters. Concurrently, there was significant improvement in global cognitive status in the aMCI subgroup of the IGs. A six-month cognitive intervention imparted cognitive benefits in patients with aMCI, which were concurrent with an attenuated decline of glucose metabolism in cortical regions affected by neurodegenerative AD.
C1 [Foerster, Stefan] Tech Univ Munich, Nukl Med Klin & Poliklin, Dept Nucl Med, D-81675 Munich, Germany.
   [Foerster, Stefan; Zach, Christian; la Fougere, Christian; Rominger, Axel; Bartenstein, Peter] Univ Munich, Dept Nucl Med, Munich, Germany.
   [Buschert, Verena C.; Buerger, Katharina] Univ Munich, Alzheimer Mem Ctr, Dementia Res Sect, Munich, Germany.
   [Buschert, Verena C.; Buerger, Katharina] Univ Munich, Alzheimer Mem Ctr, Memory Clin, Munich, Germany.
   [Buschert, Verena C.; Buerger, Katharina] Univ Munich, Dept Psychiat, Geriatr Psychiat Branch, D-8000 Munich, Germany.
   [Teipel, Stefan J.; Friese, Uwe] Univ Rostock, Dept Psychiat, Rostock, Germany.
   [Teipel, Stefan J.] German Ctr Neurodegenerat Disorders, DZNE, Rostock, Germany.
   [Hampel, Harald] Univ Dublin, Trinity Coll, Lab Neuroimaging & Biomarker Res, Sch Med,Discipline Psychiat, Dublin, Ireland.
   [Hampel, Harald] Univ Dublin, Trinity Coll, TCIN, Dublin, Ireland.
   [Buchholz, Hans-Georg] Johannes Gutenberg Univ Mainz, Dept Nucl Med, Mainz, Germany.
   [Friese, Uwe] Univ Osnabrueck, Inst Psychol, Osnabruck, Germany.
   [Buerger, Katharina] Univ Munich, Klinikum Grosshadern, Inst Stroke & Dementia Res, D-8000 Munich, Germany.
C3 Technical University of Munich; University of Munich; University of
   Munich; University of Munich; University of Munich; University of
   Munich; University of Rostock; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE); Trinity College Dublin; Trinity
   College Dublin; Johannes Gutenberg University of Mainz; University
   Osnabruck; University of Munich
RP Forster, S (corresponding author), Tech Univ Munich, Nukl Med Klin & Poliklin, Dept Nucl Med, Ismaninger Str 22, D-81675 Munich, Germany.
EM stefan-foerster@gmx.de
RI la Fougere, Christian/G-6514-2012; Lista, Simone/AAC-6473-2021;
   Rominger, Axel/K-5891-2019; la Fougère, Christian/AAN-2811-2021
OI Lista, Simone/0000-0001-6804-7858; Rominger, Axel/0000-0002-1954-736X;
   la Fougère, Christian/0000-0001-7519-0417; Drzezga,
   Alexander/0000-0001-6018-716X; Hampel, Harald/0000-0003-0894-8982
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NR 39
TC 16
Z9 16
U1 0
U2 22
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2011
VL 25
IS 4
BP 695
EP 706
DI 10.3233/JAD-2011-100996
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 803QI
UT WOS:000293595400011
PM 21498904
DA 2023-08-17
ER

PT J
AU Demurtas, J
   Schoene, D
   Torbahn, G
   Marengoni, A
   Grande, G
   Zou, LY
   Petrovic, M
   Maggi, S
   Cesari, M
   Lamb, S
   Soysal, P
   Kemmler, W
   Sieber, C
   Mueller, C
   Shenkin, SD
   Schwingshackl, L
   Smith, L
   Veronese, N
AF Demurtas, Jacopo
   Schoene, Daniel
   Torbahn, Gabriel
   Marengoni, Alessandra
   Grande, Giulia
   Zou, Liye
   Petrovic, Mirko
   Maggi, Stefania
   Cesari, Matteo
   Lamb, Sarah
   Soysal, Pinar
   Kemmler, Wolfgang
   Sieber, Cornel
   Mueller, Christoph
   Shenkin, Susan D.
   Schwingshackl, Lukas
   Smith, Lee
   Veronese, Nicola
CA European Soc Geriatric Med Special
TI Physical Activity and Exercise in Mild Cognitive Impairment and
   Dementia: An Umbrella Review of Intervention and Observational Studies
SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
LA English
DT Review
DE Physical activity; physical exercise; dementia; mild cognitive
   impairment; cognition; umbrella review
ID OUTCOMES; IMPACT; RISK
AB Objectives: The aim of this umbrella review was to determine the effect of physical activity/exercise on improving cognitive and noncognitive outcomes in people with MCI (mild cognitive impairment) and dementia.
   Design: Umbrella review of systematic reviews (SR), with or without meta-analyses (MAs), of randomized controlled trials (RCTs) and observational studies.
   Settings and Participants: People with MCI or dementia, confirmed through validated assessment measures. Any form of physical activity/exercise was included. As controls, we included participants not following any prespecified physical activity/exercise intervention or following the same standard protocol with the intervention group.
   Methods: The protocol was registered in PROSPERO (CDR 164197). Major databases were searched until December 31, 2019. The certainty of evidence of statistically significant outcomes was evaluated using the Grading of Recommendations Assessment, Development and Evaluation approach. SRs' findings, without a formal MA, were reported descriptively.
   Results: Among 1160 articles initially evaluated, 27 SRs (all of RCTs, 9 without MA) for a total of 28,205 participants with MCI/dementia were included. In patients with MCI, mind-body intervention (standardized mean difference [SMD] = 0.36; 95% confidence intervals [CI] 0.20-0.52; low certainty) and mixed physical activity interventions (SMD = 0.30; 95% CI 0.11-0.49; moderate certainty) had a small effect on global cognition, whereas resistance training (SMD = 0.80; 95% CI 0.29-1.31; very low certainty) had a large effect on global cognition. In people affected by dementia, physical activity/exercise was effective in improving global cognition in Alzheimer disease (SMD = 1.10; 95% CI 0.65-1.64; very low certainty) and in all types of dementia (SMD = 0.48; 95% CI 0.22-0.74; low certainty). Finally, physical activity/exercise improved noncognitive outcomes in people with dementia including falls, and neuropsychiatric symptoms.
   Conclusions and Implications: Supported by very low-to-moderate certainty of evidence, physical activity/exercise has a positive effect on several cognitive and noncognitive outcomes in people with MCI and dementia, but RCTs, with low risk of bias/confounding, are still needed to confirm these relationships. (C) 2020 The Author(s). Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Demurtas, Jacopo] Azienda USL Toscana Sud Est, Primary Care Dept, Grosseto, Italy.
   [Demurtas, Jacopo] Univ Modena & Reggio Emilia, Clin & Expt Med PhD Program, Modena, Italy.
   [Schoene, Daniel] Friedrich Alexander Univ Erlangen Nurnberg, Inst Med Phys, Erlangen, Germany.
   [Schoene, Daniel] Robert Bosch Krankenhaus, Dept Geriatr Rehabil, Stuttgart, Germany.
   [Torbahn, Gabriel; Sieber, Cornel] Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging, Nurnberg, Germany.
   [Marengoni, Alessandra] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.
   [Grande, Giulia] Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Grande, Giulia] Stockholm Univ, Stockholm, Sweden.
   [Zou, Liye] Shenzhen Univ, Exercise & Mental Hlth Lab, Shenzhen, Peoples R China.
   [Petrovic, Mirko] Univ Ghent, Dept Internal Med & Paediat, Sect Geriatr, Ghent, Belgium.
   [Maggi, Stefania] CNR, Neurosci Inst, Aging Branch, Padua, Italy.
   [Cesari, Matteo] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.
   [Lamb, Sarah] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Soysal, Pinar] Bezmialem Vakif Univ, Fac Med, Dept Geriatr Med, Istanbul, Turkey.
   [Kemmler, Wolfgang] Friedrich Alexander Univ Erlangen Nurnberg, Inst Med Phys, Nurnberg, Germany.
   [Mueller, Christoph] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Shenkin, Susan D.] Univ Edinburgh, Usher Inst, Geriatr Med, Edinburgh, Midlothian, Scotland.
   [Schwingshackl, Lukas] Univ Freiburg, Fac Med, Med Ctr, Inst Evidence Med, Freiburg, Germany.
   [Smith, Lee] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England.
   [Veronese, Nicola] Unite Locale Socio Sanit 3 Serenissima, Primary Care Dept, Venice, Italy.
   [Veronese, Nicola] Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, Palermo, Italy.
C3 Universita di Modena e Reggio Emilia; University of Erlangen Nuremberg;
   Bosch; Robert Bosch Krankenhaus; University of Erlangen Nuremberg;
   University of Brescia; Karolinska Institutet; Stockholm University;
   Shenzhen University; Ghent University; Consiglio Nazionale delle
   Ricerche (CNR); University of Milan; University of Oxford; Bezmialem
   Vakif University; University of Erlangen Nuremberg; University of
   London; King's College London; University of Edinburgh; University of
   Freiburg; Anglia Ruskin University; University of Palermo
RP Veronese, N (corresponding author), Azienda ULSS 3 Unity Locale Socio Sanit Serenissi, Primary Care Dept, Venice, Italy.
EM ilmannato@gmail.com
RI SOYSAL, Pinar/AAA-8894-2021; Shenkin, Susan/GWZ-3174-2022; Veronese,
   Nicola/K-4343-2018; Grande, Giulia/K-4276-2018; Demurtas,
   Jacopo/AAA-8814-2019; Demurtas, Jacopo/ACH-2667-2022; Cesari,
   Matteo/A-4649-2008; Torbahn, Gabriel/R-9991-2019; Schwingshackl,
   Lukas/AAC-4119-2019
OI Veronese, Nicola/0000-0002-9328-289X; Demurtas,
   Jacopo/0000-0003-3001-8546; Demurtas, Jacopo/0000-0003-3001-8546;
   Cesari, Matteo/0000-0002-0348-3664; Torbahn,
   Gabriel/0000-0003-1463-3119; Schwingshackl, Lukas/0000-0003-3407-7594;
   Lamb, Sarah/0000-0003-4349-7195; Shenkin, Susan/0000-0001-7375-4776;
   marengoni, alessandra/0000-0002-4851-1825; Zou, Liye/0000-0001-6411-5710
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NR 32
TC 60
Z9 64
U1 5
U2 36
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1525-8610
EI 1538-9375
J9 J AM MED DIR ASSOC
JI J. Am. Med. Dir. Assoc.
PD OCT
PY 2020
VL 21
IS 10
BP 1415
EP +
DI 10.1016/j.jamda.2020.08.031
PG 14
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA NY9IM
UT WOS:000576698600013
PM 32981668
OA Green Accepted, Green Published, hybrid, Green Submitted
DA 2023-08-17
ER

PT J
AU Tulliani, N
   Bissett, M
   Bye, R
   Chaudhary, K
   Fahey, P
   Liu, KRPY
AF Tulliani, Nikki
   Bissett, Michelle
   Bye, Rosalind
   Chaudhary, Katrina
   Fahey, Paul
   Liu, Karen P. Y.
TI The efficacy of cognitive interventions on the performance of
   instrumental activities of daily living in individuals with mild
   cognitive impairment or mild dementia: protocol for a systematic review
   and meta-analysis
SO SYSTEMATIC REVIEWS
LA English
DT Review
DE Cognitive interventions; Instrumental activities of daily living; Mild
   cognitive impairment; Mild dementia; Protocol for systematic review
ID CLINICAL-DIAGNOSIS; ALZHEIMERS-DISEASE; OLDER-ADULTS; DECLINE;
   PREDICTORS; ASSOCIATION; COMMUNITY; PROGRAMS; OUTCOMES
AB Background Cognitive changes associated with mild cognitive impairment or mild dementia can lead to difficulties in completing instrumental activities of daily living. The ability to live independently at home and in the community is often compromised due to the inability to complete these activities. Cognitive interventions have been reported as beneficial in maintaining or improving cognitive functions among this group of adults. However, the effectiveness of different types of cognitive interventions on the performance of instrumental activities of daily living in older adults with mild cognitive impairment and mild dementia is not well established. The aim of this paper is to develop a protocol for a systematic review and meta-analysis to investigate the effectiveness of cognitive interventions in maintaining or improving the performance of instrumental activities of daily living in individuals with mild cognitive impairment or mild dementia. Methods Randomised control studies which investigate the effectiveness of cognitive interventions on the performance in instrumental activities of daily living for older adults with mild cognitive impairment and mild dementia will be sought. A systematic search will be conducted in five databases: CINAHL, MEDLINE, EMBASE, PsycINFO and Cochrane Central Register of Controlled Trials. The search strategy was developed with assistance from a health science librarian. Two independent reviewers will perform the study selection and data extraction. Quality assessment will be implemented using the Physiotherapy Evidence Database (PEDro) scale. A narrative synthesis of the findings will be used to report outcomes of all included studies. If appropriate, a meta-analysis will combine the results of individual studies. Discussion This systematic review and meta-analysis will determine the effectiveness of cognitive interventions in maintaining or improving the performance of IADL in individuals with MCI or mild dementia. It is anticipated that the results will inform rehabilitation professionals of the most effective cognitive interventions to be implemented into clinical practice. It will potentially provide substantial benefit to both the persons with MCI or dementia and the health care system by keeping more people out of full-time care and allowing those in full-time care to require less intensive support. Systematic review registration PROSPERO CRD42016042364
C1 [Tulliani, Nikki; Bye, Rosalind; Chaudhary, Katrina; Fahey, Paul; Liu, Karen P. Y.] Western Sydney Univ, Sch Sci & Hlth, Penrith, NSW, Australia.
   [Liu, Karen P. Y.] Western Sydney Univ, Translat Hlth Res Inst, Penrith, NSW, Australia.
   [Bissett, Michelle] Griffith Univ, Sch Allied Hlth Sci, Gold Coast, Qld, Australia.
C3 Western Sydney University; Western Sydney University; Griffith
   University
RP Liu, KRPY (corresponding author), Western Sydney Univ, Sch Sci & Hlth, Penrith, NSW, Australia.; Liu, KRPY (corresponding author), Western Sydney Univ, Translat Hlth Res Inst, Penrith, NSW, Australia.
EM karen.liu@westernsydney.edu.au
RI Bissett, Michelle/ABD-7529-2020; Bye, Rosalind/U-7799-2019; Liu,
   Karen/ABG-1646-2020; Fahey, Paul P/B-7985-2013
OI Bissett, Michelle/0000-0001-7676-4662; Bye,
   Rosalind/0000-0001-7539-5930; Liu, Karen/0000-0001-7397-5149; Fahey,
   Paul P/0000-0002-6351-9876; Tulliani, Nikki/0000-0002-8574-9285
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NR 63
TC 9
Z9 9
U1 3
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2046-4053
J9 SYST REV-LONDON
JI Syst. Rev.
PD AUG 28
PY 2019
VL 8
IS 1
AR 222
DI 10.1186/s13643-019-1135-0
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IU1US
UT WOS:000483362600001
PM 31462306
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Spargo, C
   Laver, K
   Berndt, A
   Adey-Wakeling, Z
   George, S
AF Spargo, Claire
   Laver, Kate
   Berndt, Angela
   Adey-Wakeling, Zoe
   George, Stacey
TI Occupational Therapy Interventions to ImproveDriving Performance inOlder
   People With Mild Cognitive Impairment or Early-Stage Dementia: A
   Systematic Review
SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Review
ID ALZHEIMERS-DISEASE; DRIVING CESSATION; OLDER-ADULTS; DRIVER
   REHABILITATION; SAFETY; SIMULATOR; ERRORS; ROAD; METAANALYSIS; BEHAVIORS
AB Importance: For a person with mild cognitive impairment (MCI) or early-stage dementia, driving is important for independence. However, driving presents safety concerns for both the person and family members. It is important to determine whether occupational therapy interventions can prolong safe driving for this population.
   Objective: To determine the effectiveness of occupational therapy interventions to improve driving performance in older people with MCI or early-stage dementia.
   Data Sources: We conducted a search of MEDLINE, PsycINFO, CINAHL, and gray literature using Google Scholar.
   Study Selection and Data Collection: Studies were included if they evaluated interventions that (1) aimed to improve the driving performance of older people (M age >= 60 yr) with MCI or early-stage dementia and (2) could be designed or delivered by an occupational therapy practitioner who specializes in driving. Citations were reviewed independently by two authors, and quality appraisal was conducted using the Cochrane risk-of-bias guidelines.
   Findings: One Level I randomized controlled trial (RCT) and 4 Level III quasi-experimental studies were included; these studies had 231 participants in total with reported M ages of 65.6-72.5 yr. One study evaluated a compensatory approach, whereas the others evaluated a remedial approach. The studies used different measures to assess outcomes and reported mixed effects.
   Conclusions and Relevance: Low strength of evidence suggests that occupational therapy interventions may improve the driving performance of older people with MCI or early-stage dementia. More RCTs are needed that include long-term follow-up measures and address clinically important outcomes.
   What This Article Adds: In the absence of conclusive evidence from research studies and best practice guidelines, occupational therapy practitioners must rely on their clinical experience and their clients' abilities. Development of evidence and guidelines in this area is critical. It is also important for practitioners to work closely with clients, families, and interdisciplinary team members to carefully monitor fitness to drive.
C1 [Spargo, Claire] Flinders Univ S Australia, Caring Futures Inst, Coll Nursing & Hlth Sci, Adelaide, SA, Australia.
   [Laver, Kate; Adey-Wakeling, Zoe] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Coll Med & Publ Hlth, Adelaide, SA, Australia.
   [Berndt, Angela] Univ South Australia, Allied Hlth & Human Performance, Adelaide, SA, Australia.
   [Adey-Wakeling, Zoe] Flinders Med Ctr, Rehabil Aged & Palliat Care, Adelaide, SA, Australia.
   [George, Stacey] Flinders Univ S Australia, Caring Futures Inst, Coll Nursing & Hlth Sci, Occupat Therapy, Adelaide, SA, Australia.
C3 Flinders University South Australia; Flinders University South
   Australia; University of South Australia; Flinders Medical Centre;
   Flinders University South Australia
RP George, S (corresponding author), Flinders Univ S Australia, Caring Futures Inst, Coll Nursing & Hlth Sci, Occupat Therapy, Adelaide, SA, Australia.
EM stacey.george@flinders.edu.au
RI Laver, Kate/AFM-0623-2022; Spargo, Claire/HKP-0981-2023; Berndt,
   Angela/F-3853-2013; George, Stacey/H-2240-2018
OI Laver, Kate/0000-0003-0259-2209; Berndt, Angela/0000-0002-5473-5155;
   George, Stacey/0000-0002-0859-0215; Spargo, Claire/0000-0002-1003-0911
FU Dementia Australia Research Foundation PhD scholarship
FX This systematic review was registered on PROSPERO on February 20, 2019
   (CRD42019111294). This work was supported by a Dementia Australia
   Research Foundation PhD scholarship.
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NR 56
TC 1
Z9 1
U1 4
U2 11
PU AMER OCCUPATIONAL THERAPY ASSOC, INC
PI BETHESDA
PA 4720 MONTGOMERY LANE, BETHESDA, MD 20814-3425 USA
SN 0272-9490
EI 1943-7676
J9 AM J OCCUP THER
JI Am. J. Occup. Ther.
PD SEP-OCT
PY 2021
VL 75
IS 5
AR 7505205070
DI 10.5014/ajot.2021.042820
PG 14
WC Rehabilitation
WE Social Science Citation Index (SSCI)
SC Rehabilitation
GA YK3ER
UT WOS:000745101100013
PM 34780644
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Greenaway, MC
   Hanna, SM
   Lepore, SW
   Smith, GE
AF Greenaway, Melanie C.
   Hanna, Sherrie M.
   Lepore, Susan W.
   Smith, Glenn E.
TI A Behavioral Rehabilitation Intervention for Amnestic Mild Cognitive
   Impairment
SO AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
LA English
DT Article; Proceedings Paper
CT 10th International Conference on Alzheimers Disease and Related
   Disorders
CY JUL 15-16, 2006-2007
CL Madrid, SPAIN
DE mild cognitive impairment; cognitive rehabilitation; memory loss;
   functional ability; behavioral interventions; memory notebook
AB Individuals with amnestic mild cognitive impairment (MCI) Currently have few treatment options for combating their memory loss. The Memory Support System (MSS) is a calendar and organization system with accompanying 6-week Curriculum designed for individuals with progressive memory impairment. Ability to learn the MSS and its utility were assessed in 20 participants. Participants were significantly more likely to Successfully use the calendar system after training. Ninety-five percent were compliant with the MSS at training completion, and 89% continued to be compliant at follow-up. Outcome measures revealed a medium effect size for improvement in functional ability Subjects further reported improved independence, self-confidence, and mood. This initial examination of the MSS suggests that with appropriate training, individuals with amnestic MCI can and will use a memory notebook system to help compensate for memory loss. These results are encouraging that the MSS may help with the symptoms of memory decline in MCI.
C1 [Greenaway, Melanie C.] Emory Univ, Wesley Woods Hlth Ctr Neurol, Sch Med, Atlanta, GA 30329 USA.
   [Hanna, Sherrie M.; Lepore, Susan W.; Smith, Glenn E.] Mayo Clin, Rochester, MN USA.
C3 Emory University; Mayo Clinic
RP Greenaway, MC (corresponding author), Emory Univ, Wesley Woods Hlth Ctr Neurol, Sch Med, 1841 Clifton Rd NE, Atlanta, GA 30329 USA.
EM mcgree3@emory.edu
OI Smith, Glenn/0000-0003-1506-9484
FU NIA NIH HHS [P50 AG016574-05, P50 AG016574, P50 AG16574] Funding Source:
   Medline
CR [Anonymous], 1990, MEMORY BEHAV PROBLEM
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NR 11
TC 65
Z9 68
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1533-3175
EI 1938-2731
J9 AM J ALZHEIMERS DIS
JI Am. J. Alzheimers Dis. Other Dement.
PD OCT-NOV
PY 2008
VL 23
IS 5
BP 451
EP 461
DI 10.1177/1533317508320352
PG 11
WC Geriatrics & Gerontology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 364BY
UT WOS:000260312400007
PM 18955724
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Di Lorito, C
   Bosco, A
   Booth, V
   Goldberg, S
   Harwood, RH
   Van der Wardt, V
AF Di Lorito, Claudio
   Bosco, Alessandro
   Booth, Vicky
   Goldberg, Sarah
   Harwood, Rowan H.
   Van der Wardt, Veronika
TI Adherence to exercise interventions in older people with mild cognitive
   impairment and dementia: A systematic review and meta-analysis
SO PREVENTIVE MEDICINE REPORTS
LA English
DT Review
DE Systematic review; Mild cognitive impairment; Dementia; Adherence;
   Physical exercise; Physical activity
ID NURSING-HOME RESIDENTS; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY;
   TRAINING-PROGRAM; AEROBIC EXERCISE; ELDERLY PERSONS; PERFORMANCE;
   ADULTS; BALANCE; REHABILITATION
AB Adherence to physical exercise is associated with multiple benefits in people with mild cognitive impairment (MCI) and dementia. Given the gap in research, this systematic literature review aimed to determine in the context of exercise intervention studies for people with MCI and dementia: 1. How adherence is defined, monitored and recorded; 2. Adherence rates; 3. Attrition, compliance and adverse events and 4. Intervention characteristics associated with adherence. Embase, Medline, PsychInfo, SPORTDiscus, AMED, CINAHL and the International Bibliography of Social Sciences were searched in November 2018. The data were analyzed through descriptive and correlation/inferential statistics. Forty-one studies were included, 34 involving participants with dementia (n = 2149) and seven participants with MCI (n = 970). Half of the studies operationally defined adherence. Mean adherence rate was 70% [CI, 69-73%]. Adherence was significantly associated with endurance/resistance training, and interventions not including walking. The review found a lack of consistency around reporting of adherence and of key variables mediating adherence, including compliance, attrition and adverse events. Further research using more reliable measures is needed to confirm whether a correlation exists between length of interventions and adherence in participants with MCI and dementia and to identify the factors or strategies that mediate adherence in this population. Relevant implications for practice include a consideration in the development of new interventions of elements associated with higher adherence in this review, such as endurance/resistance training, and the provision of exercise in group formats.
C1 [Di Lorito, Claudio; Booth, Vicky] Univ Nottingham, Queens Med Ctr, Sch Med, Div Rehabil Ageing & Wellbeing, Room B109, Nottingham NG7 2UH, England.
   [Bosco, Alessandro] Univ Nottingham, Sch Med, Inst Mental Hlth, Div Psychiat & Appl Psychol, Triumph Rd, Nottingham NG7 2TU, England.
   [Goldberg, Sarah; Harwood, Rowan H.] Univ Nottingham, Queens Med Ctr, Sch Hlth Sci, Nottingham NG7 2UH, England.
   [Van der Wardt, Veronika] Philipps Univ Marburg, Zentrum Methodenwissensch, Karl von Frisch Str 4, D-35032 Marburg, Germany.
   [Van der Wardt, Veronika] Philipps Univ Marburg, Gesundheitsforsch Abt Allgemeinmed Pravent & Reha, Karl von Frisch Str 4, D-35032 Marburg, Germany.
C3 University of Nottingham; University of Nottingham; University of
   Nottingham; Philipps University Marburg; Philipps University Marburg
RP Di Lorito, C (corresponding author), Univ Nottingham, Queens Med Ctr, Sch Med, Div Rehabil Ageing & Wellbeing, Room B109, Nottingham NG7 2UH, England.
EM Claudio.dilorito@nottingham.ac.uk
RI van der Wardt, Veronika/ABF-3836-2021
OI van der Wardt, Veronika/0000-0003-3995-7056; Di Lorito,
   Claudio/0000-0002-8953-0117; Bosco, Alessandro/0000-0002-2374-3427;
   Booth, Vicky/0000-0002-5338-0196; Goldberg, Sarah/0000-0001-5109-798X;
   Harwood, Rowan/0000-0002-4920-6718
FU National Institute for Health Research (NIHR) under its Program Grants
   for Applied Research Program [RP-PG-0614-20007]
FX This work was funded by the National Institute for Health Research
   (NIHR) under its Program Grants for Applied Research Program (Reference
   Number RP-PG-0614-20007).
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TC 21
Z9 21
U1 2
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2211-3355
J9 PREV MED REP
JI Prev. Med. Rep.
PD SEP
PY 2020
VL 19
AR 101139
DI 10.1016/j.pmedr.2020.101139
PG 22
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA RV0ZB
UT WOS:000645565500040
PM 32793408
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Schaham, NG
   Vitek, H
   Donda, N
   Golan, IE
   Buckman, Z
   Rand, D
AF Givon Schaham, Noa
   Vitek, Hila
   Donda, Noam
   Elbo Golan, Inbal
   Buckman, Zvi
   Rand, Debbie
TI The Development and Feasibility of TECH: Tablet Enhancement of Cognition
   and Health, a Novel Cognitive Intervention for People with Mild
   Cognitive Impairment
SO GAMES FOR HEALTH JOURNAL
LA English
DT Article
DE Cognitive training; iPad; Puzzle games
ID OLDER-ADULTS; TECHNOLOGY; INDIVIDUALS; ENGAGEMENT; PROGRAMS; DECLINE
AB Objectives:Cognitive training using technology has potential to be an effective treatment method for people with mild cognitive impairment (MCI). Touchscreen tablet applications might provide a fun and motivating way to engage in cognitive training for people with MCI. This study presents the development of TECH: "Tablet Enhancement of Cognition and Health," a novel cognitive intervention utilizing touchscreen tablet applications for self-training, and we aimed to examine TECH's feasibility and satisfaction for older adults with MCI.
   Materials and Methods:TECH development was based on the review of research evidence to identify important demands for effective cognitive training, and discussions with occupational therapists with experience using touchscreen tablets for treating individuals with cognitive impairments. Feasibility of TECH was assessed in terms of adherence (session attendance), compliance (total self-training hours), and satisfaction from the intervention.
   Results:Twenty-eight community-dwelling older adults with MCI participated in the study and received TECH. Participants attended at least 80% of group sessions, they self-trained a mean (standard deviation [SD]) 20.9 (7.2) sessions for 5 weeks, mean (SD) total training time of 24.4 (11.9) hours, 4.9 h/week. Very high satisfaction with the intervention was reported by 78% of the 23 participants who filled in the questionnaire.
   Conclusions:The newly developed TECH intervention was found to be feasible for older adults with MCI. Participants were willing and able to perform the self-training at home, which provided a motivating cognitive leisure activity facilitated by weekly group sessions. Data are now collected to establish the effectiveness of TECH as a cognitive intervention, compared with a control group, for people with MCI.
C1 [Givon Schaham, Noa; Vitek, Hila; Donda, Noam; Rand, Debbie] Tel Aviv Univ, Steyer Sch Hlth Profess, Dept Occupat Therapy, Sackler Fac Med, Tel Aviv, Israel.
   [Givon Schaham, Noa; Elbo Golan, Inbal; Buckman, Zvi] Maccabi Healthcare Serv, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine
RP Rand, D (corresponding author), Tel Aviv Univ, Dept Occupat Therapy, Sackler Fac Med, Sch Hlth Profess, POB 39040, IL-6997801 Tel Aviv, Israel.
EM drand@tauex.tau.ac.il
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NR 30
TC 1
Z9 1
U1 2
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2161-783X
EI 2161-7856
J9 GAMES HEALTH J
JI Games Health J.
PD OCT 1
PY 2020
VL 9
IS 5
BP 346
EP 352
DI 10.1089/g4h.2019.0157
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Rehabilitation
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Rehabilitation
GA NZ7IY
UT WOS:000577278500004
PM 33054487
DA 2023-08-17
ER

PT J
AU Xu, ZJ
   Sun, W
   Zhang, DX
   Chung, VCH
   Wong, SYS
AF Xu, Zijun
   Sun, Wen
   Zhang, Dexing
   Chung, Vincent Chi-Ho
   Wong, Samuel Yeung-Shan
TI Comparative effectiveness of non-pharmacological interventions for
   depressive symptoms in mild cognitive impairment: systematic review with
   network meta-analysis
SO AGING & MENTAL HEALTH
LA English
DT Review
DE systematic review; network meta-analysis; mild cognitive impairment;
   depressive symptoms; non-pharmacological interventions
ID OLDER-ADULTS; DEMENTIA; HEALTH; DECLINE; CARE
AB Objectives Depressive symptoms are common among mild cognitive impairment (MCI) patients. It is unknown how different the effects on depressive symptoms are among various pharmacological MCI interventions. This systematic review aimed to evaluate the comparative effectiveness of non-pharmacological MCI interventions on depressive symptoms among MCI patients. Methods A systematic review and network meta-analysis was conducted on randomized controlled trials (RCT) comparing the effect of different non-pharmacological MCI interventions on changes in depressive symptoms among MCI patients. RCTs were identified from MEDLINE, EMBASE, Cochrane Library, CINAHL, PsycINFO, and PsycARTICLES. Results were summarized as standardized mean differences (SMD) and 95% confidence intervals (CI). The surface under the cumulative ranking (SUCRA) was used to rank the effect of different interventions. Results Twenty-two RCTs were included in the network meta-analysis. Compared with non-active control, cognition-based intervention (SMD=-0.25, 95% CI: -0.46, -0.04) and physical exercise (SMD=-0.33, 95% CI: -0.56, -0.10) had significant positive effects to reduce depressive symptoms. Health education, psychosocial intervention, and the combination of physical exercise and cognition-based intervention had non-significant overall effects. The SUCRA demonstrated that physical exercise had the highest SUCRA for the reduction in depression symptoms (0.815). In subgroup analysis, health education, cognition-based intervention, physical exercise, and the combination of physical exercise and cognition-based intervention showed significant longer-term effects (6-12 months). Conclusion Physical exercise and cognition-based intervention were effective interventions for depressive symptoms in MCI patients. This study can provide additional evidence for healthcare providers to make decisions for selecting available and appropriate interventions for MCI patients.
C1 [Xu, Zijun; Sun, Wen; Zhang, Dexing; Chung, Vincent Chi-Ho; Wong, Samuel Yeung-Shan] Chinese Univ Hong Kong, Fac Med, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Wong, SYS (corresponding author), Chinese Univ Hong Kong, Fac Med, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China.
EM yeungshanwong@cuhk.edu.hk
RI Chung, Vincent CH/K-2447-2013
OI Chung, Vincent CH/0000-0002-5947-4492; Sun, Wen/0000-0001-9951-405X;
   ZHANG, Dexing/0000-0003-0073-4752
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NR 49
TC 4
Z9 4
U1 3
U2 15
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD OCT 28
PY 2022
VL 26
IS 11
BP 2129
EP 2135
DI 10.1080/13607863.2021.1998356
EA OCT 2021
PG 7
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 5N4LD
UT WOS:000723540700001
PM 34841997
DA 2023-08-17
ER

PT J
AU Kwag, E
   Stuckenschneider, T
   Schneider, S
   Abeln, V
AF Kwag, Eunyoung
   Stuckenschneider, Tim
   Schneider, Stefan
   Abeln, Vera
TI The effect of a psychomotor intervention on electroencephalography and
   neuropsychological performances in older adults with and without mild
   cognitive impairment
SO PSYCHOGERIATRICS
LA English
DT Article
DE affect; aged; ageing; cognitive dysfunction; electroencephalography;
   memory
ID VERBAL LEARNING TEST; EPISODIC MEMORY; NEGATIVE AFFECT; EXERCISE;
   PROGRESSION; MOOD; EEG; DEPRESSION; PROTOCOL; ANXIETY
AB Aim The aim of this pilot study was to examine the acute effect of a psychomotor intervention (PMI) on auditory-verbal memory, emotional state, and electrocortical activity recorded by electroencephalography on subjectively healthy older adults (sHE) and older adults diagnosed with mild cognitive impairment (MCIs).
   Methods Eleven MCIs and 11 sHE underwent a single 45-min PMI. Resting state electroencephalography, the Rey Auditory-Verbal Learning Test, MoodMeter (R), and the Positive and Negative Affect Schedule were compared between groups and pre- and post-PMI.
   Results Electroencephalography current source density and activity within the theta frequency band were higher in MCIs than in sHE at baseline, and brain frequency had a tendency to decrease in MCIs after training. Both groups showed improvement on the auditory-verbal memory test. Only among MCIs were there increases in perceived physical state and psychological strain and an improvement in negative affect.
   Conclusions Our findings suggest that acute psychomotor activity may be more effective for MCIs than for sHE. It supports the notion that PMI does have functional influences on the central nervous level and therefore might prevent and treat cognitive, psychological, and psychiatric symptoms of people with mild cognitive impairment.
C1 [Kwag, Eunyoung] German Sport Univ Cologne, Inst Movement & Sport Gerontol, Cologne, Germany.
   [Stuckenschneider, Tim; Schneider, Stefan; Abeln, Vera] German Sport Univ Cologne, Inst Movement & Neurosci, Sportpk Muengersdorf 6, D-50933 Cologne, Germany.
C3 German Sport University Cologne; German Sport University Cologne
RP Abeln, V (corresponding author), German Sport Univ Cologne, Inst Movement & Neurosci, Sportpk Muengersdorf 6, D-50933 Cologne, Germany.
EM v.abeln@dshs-koeln.de
RI Stuckenschneider, Tim/AAK-1267-2021; Abeln, Vera/HNQ-7050-2023
OI Stuckenschneider, Tim/0000-0002-0972-4377; Kwag,
   Eunyoung/0000-0002-9243-3895; Abeln, Vera/0000-0003-4054-438X
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NR 56
TC 1
Z9 1
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1346-3500
EI 1479-8301
J9 PSYCHOGERIATRICS
JI Psychogeriatrics
PD JUL
PY 2021
VL 21
IS 4
BP 528
EP 539
DI 10.1111/psyg.12702
EA MAY 2021
PG 12
WC Geriatrics & Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Psychiatry
GA TC8WO
UT WOS:000647883900001
PM 33960574
OA hybrid
DA 2023-08-17
ER

PT J
AU Blackman, J
   Swirski, M
   Clynes, J
   Harding, S
   Leng, Y
   Coulthard, E
AF Blackman, Jonathan
   Swirski, Marta
   Clynes, James
   Harding, Sam
   Leng, Yue
   Coulthard, Elizabeth
TI Pharmacological and non-pharmacological interventions to enhance sleep
   in mild cognitive impairment and mild Alzheimer's disease: A systematic
   review
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Review
DE AD; Alzheimer&apos; s dementia; Alzheimer&apos; s disease; MCI; mild
   cognitive impairment; sleep
ID BETA DYNAMICS; DOUBLE-BLIND; REM-SLEEP; DONEPEZIL; DEMENTIA;
   STIMULATION; DISTURBANCE; BIOMARKERS; DISORDERS; INSOMNIA
AB Suboptimal sleep causes cognitive decline and probably accelerates Alzheimer's Disease (AD) progression. Several sleep interventions have been tested in established AD dementia cases. However early intervention is needed in the course of AD at Mild Cognitive Impairment (MCI) or mild dementia stages to help prevent decline and maintain good quality of life. This systematic review aims to summarize evidence on sleep interventions in MCI and mild AD dementia. Seven databases were systematically searched for interventional studies where >= 75% of participants met diagnostic criteria for MCI/mild AD dementia, with a control group and validated sleep outcome measures. Studies with a majority of participants diagnosed with Moderate to Severe AD were excluded. After removal of duplicates, 22,133 references were returned in two separate searches (August 2019 and September 2020). 325 full papers were reviewed with 18 retained. Included papers reported 16 separate studies, total sample (n = 1,056), mean age 73.5 years. 13 interventions were represented: Cognitive Behavioural Therapy - Insomnia (CBT-I), A Multi-Component Group Based Therapy, A Structured Limbs Exercise Programme, Aromatherapy, Phase Locked Loop Acoustic Stimulation, Transcranial Stimulation, Suvorexant, Melatonin, Donepezil, Galantamine, Rivastigmine, Tetrahydroaminoacridine and Continuous Positive Airway Pressure (CPAP). Psychotherapeutic approaches utilising adapted CBT-I and a Structured Limbs Exercise Programme each achieved statistically significant improvements in the Pittsburgh Sleep Quality Index with one study reporting co-existent improved actigraphy variables. Suvorexant significantly increased Total Sleep Time and Sleep Efficiency whilst reducing Wake After Sleep Onset time. Transcranial Stimulation enhanced cortical slow oscillations and spindle power during daytime naps. Melatonin significantly reduced sleep latency in two small studies and sleep to wakefulness transitions in a small sample. CPAP demonstrated efficacy in participants with Obstructive Sleep Apnoea. Evidence to support other interventions was limited. Whilst new evidence is emerging, there remains a paucity of evidence for sleep interventions in MCI and mild AD highlighting a pressing need for high quality experimental studies exploring alternative sleep interventions.
C1 [Blackman, Jonathan; Swirski, Marta; Harding, Sam] North Bristol NHS Trust, Bristol, Avon, England.
   [Blackman, Jonathan; Coulthard, Elizabeth] Univ Bristol, Bristol Med Sch, Bristol, Avon, England.
   [Clynes, James] Univ Bath, Bath, Avon, England.
   [Leng, Yue] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
C3 North Bristol NHS Trust; University of Bristol; University of Bath;
   University of California System; University of California San Francisco
RP Coulthard, E (corresponding author), Univ Bristol, Learning & Res, Bristol BS10 5NB, Southmead, England.
EM Elizabeth.coulthard@bristol.ac.uk
OI Harding, Sam/0000-0002-5870-2094; Blackman,
   Jonathan/0000-0001-9579-9860; coulthard, elizabeth/0000-0002-0017-9595
FU North Bristol NHS Trust Research Capability Funding; Bristol Research
   into Alzheimer's Care of the Elderly (BRACE)
FX North Bristol NHS Trust Research Capability Funding; Bristol Research
   into Alzheimer's Care of the Elderly (BRACE)
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NR 71
TC 23
Z9 25
U1 8
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD AUG
PY 2021
VL 30
IS 4
AR e13229
DI 10.1111/jsr.13229
EA DEC 2020
PG 20
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA TD3HV
UT WOS:000594725100001
PM 33289311
OA hybrid, Green Published, Green Submitted
DA 2023-08-17
ER

PT J
AU Lu, YYF
   Haase, JE
   Weaver, M
AF Lu, Yvonne Yueh-Feng
   Haase, Joan E.
   Weaver, Michael
TI Pilot Testing a Couples-Focused Intervention for Mild Cognitive
   Impairment
SO JOURNAL OF GERONTOLOGICAL NURSING
LA English
DT Article
ID CAREGIVERS; ENVIRONMENT; DEPRESSION; VALIDITY; BURDEN; SPOUSE; LIFE
AB The purpose of this pilot study was to evaluate the acceptability, feasibility, and potential benefits of the multicomponent Daily Enhancement of Meaningful Activity (DEMA) intervention, which was tailored to help couples facing mild cognitive impairment (MCI) work together to meet goals, remain engaged in meaningful activities, and adapt to changes over time. Using a single- group design, 10 individuals with MCI and their family caregivers were recruited to participate in the DEMA intervention over 6 biweekly sessions. Data were collected pre- and at 1 week and 3 months postintervention. Consent, session, and questionnaire completion rates indicated the program and study procedures were well accepted. Qualitative and quantitative findings indicated positive trends in meaningful activity performance and maintenance of health-related outcomes, as well as high program satisfaction. The DEMA intervention is potentially promising but needs further testing in a randomized clinical trial.
C1 [Lu, Yvonne Yueh-Feng; Haase, Joan E.; Weaver, Michael] Indiana Univ Sch Nursing, Ctr Nursing Res & Scholarship, Dept Environm Hlth, Indianapolis, IN 46202 USA.
   [Weaver, Michael] Indiana Univ Sch Nursing, Ctr Nursing Res & Scholarship, Dept Environm Hlth, Stat Serv, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University-Purdue University
   Indianapolis; Indiana University System; Indiana University-Purdue
   University Indianapolis
RP Lu, YYF (corresponding author), Indiana Univ Sch Nursing, 1111 Middle Dr,NU W407, Indianapolis, IN 46202 USA.
EM yuelu@iupui.edu
OI Weaver, Michael/0000-0002-6630-4758
FU National Institutes of Health, National Institute of Nursing Research
   [1K01 NR010854- 01]
FX The authors have disclosed no potential conflicts of interest, financial
   or otherwise. Funding for this study was received from the National
   Institutes of Health, National Institute of Nursing Research (1K01
   NR010854- 01).
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NR 31
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Z9 9
U1 0
U2 19
PU SLACK INC
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PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0098-9134
EI 1938-243X
J9 J GERONTOL NURS
JI J. Gerontol. Nurs.
PD MAY
PY 2013
VL 39
IS 5
BP 16
EP 23
DI 10.3928/00989134-20130403-01
PG 8
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA 164XZ
UT WOS:000320447200003
PM 23767062
OA Green Accepted, Green Submitted
DA 2023-08-17
ER

PT J
AU Cheng, ST
   Li, KK
   Or, PPL
   Losada, A
AF Cheng, Sheung-Tak
   Li, Kin-Kit
   Or, Peggy P. L.
   Losada, Andres
TI Do Caregiver Interventions Improve Outcomes in Relatives With Dementia
   and Mild Cognitive Impairment? A Comprehensive Systematic Review and
   Meta-Analysis
SO PSYCHOLOGY AND AGING
LA English
DT Review; Early Access
DE dementia; Alzheimer's disease; family caregiving; caregiver
   interventions; meta-analysis
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; HONG-KONG CHINESE;
   SKILL-BUILDING PROGRAM; ALZHEIMERS-DISEASE; FAMILY CAREGIVERS;
   BEHAVIORAL-PROBLEMS; SUPPORT PROGRAM; NONPHARMACOLOGICAL INTERVENTIONS;
   COST-EFFECTIVENESS
AB Some reviews suggest benefits of nonpharmacological interventions for informal caregivers of people with dementia and mild cognitive impairment. These benefits may transfer to the care-recipients (CRs) through increased caregiving capability, reduced burden and depression among caregivers, and decreased negative mood contagion. However, large-scale review on these effects on the CRs is lacking. We searched PsycINFO, CINAHL with Full Text, MEDLINE, and PubMed from inception to end of 2020 and found 142 articles that reported randomized controlled trials (RCTs) of caregiver interventions using CR outcomes. Interventions were found to reduce neuropsychiatric symptoms (NPS) in general and behavioral and mood disturbance specifically, enhance cognition and quality of life, and delay institutionalization and mortality, with care coordination/case management, educational intervention with psychotherapeutic components (psychoeducation-b), and direct training of the CR (with caregiver involvement) being the more potent interventions. The kinds of benefit depend on the types of intervention. NPS was reduced by psychoeducation-b, care coordination/case management, and CR training. Cognition and quality of life were enhanced by CR training and care coordination/case management, respectively. Institutionalization was delayed by multicomponent interventions and respite (based on one study). However, the effects were generally small to very small. Together with existing findings on caregiver outcomes, a tripartite scaffolding model of caregiver support is proposed. The model is composed of three components: (a) care coordination/case management (i.e., enhanced usual care), (b) psychoeducation-b, and (c) CR training. Future directions in terms of developing consensual guidelines, a registry of intervention manuals, and family-centered programs with flexibility in delivery are discussed.
   Public Significance Statement Beyond the benefits for the caregivers themselves, psychosocial interventions targeting mainly caregivers also improve the conditions of the persons with dementia, though to a lesser degree. Such findings provide further support for the value of caregiver interventions as societies confront a rising dementia population. Long-term enhanced care alongside education with psychotherapeutic content and individualized training for the families may be an optimal approach.
C1 [Cheng, Sheung-Tak; Or, Peggy P. L.] Educ Univ Hong Kong, Dept Hlth & Phys Educ, Hong Kong, Peoples R China.
   [Cheng, Sheung-Tak] Univ East Anglia, Norwich Med Sch, Dept Clin Psychol, Norwich, Norfolk, England.
   [Li, Kin-Kit] City Univ Hong Kong, Dept Social & Behav Sci, 83 Tat Chee Ave, Hong Kong, Peoples R China.
   [Losada, Andres] Univ Rey Juan Carlos, Dept Psychol, Madrid, Spain.
C3 Education University of Hong Kong (EdUHK); University of East Anglia;
   City University of Hong Kong; Universidad Rey Juan Carlos
RP Li, KK (corresponding author), City Univ Hong Kong, Dept Social & Behav Sci, 83 Tat Chee Ave, Hong Kong, Peoples R China.; Cheng, ST (corresponding author), Educ Univ Hong Kong, Dept Hlth & Phys Educ, Tai Po, 10 Ping Rd, Hong Kong, Peoples R China.
EM takcheng@eduhk.hk; ben.li@cityu.edu.hk
FU Humanities and Social Sciences Prestigious Fellowship from the Research
   Grants Council of Hong Kong [38000720]; Spanish Ministry of Science and
   Innovation [PID2019-106714RB-C21]
FX Sheung-Tak Cheng was supported by a Humanities and Social Sciences
   Prestigious Fellowship from the Research Grants Council of Hong Kong
   Grant No. 38000720. Andres Losada was supported in part by funding from
   the Spanish Ministry of Science and Innovation (PID2019-106714RB-C21).
   The funding bodies played no role in the conceptualization or execution
   of the study, or the analysis or interpretation of data.
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NR 202
TC 2
Z9 2
U1 5
U2 12
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0882-7974
EI 1939-1498
J9 PSYCHOL AGING
JI Psychol. Aging
PD 2022 JUN 30
PY 2022
DI 10.1037/pag0000696
EA JUN 2022
PG 26
WC Gerontology; Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA 2N0IA
UT WOS:000818072500001
PM 35771500
DA 2023-08-17
ER

PT J
AU Stuckenschneider, T
   Sanders, ML
   Devenney, KE
   Aaronson, JA
   Abeln, V
   Claassen, JAHR
   Guinan, E
   Lawlor, B
   Meeusen, R
   Montag, C
   Rikkert, MGMO
   Polidori, MC
   Reuter, M
   Schulz, RJ
   Vogt, T
   Weber, B
   Kessels, RPC
   Schneider, S
AF Stuckenschneider, Tim
   Sanders, Marit L.
   Devenney, Kate E.
   Aaronson, Justine A.
   Abeln, Vera
   Claassen, Jurgen A. H. R.
   Guinan, Emer
   Lawlor, Brian
   Meeusen, Romain
   Montag, Christian
   Olde Rikkert, Marcel G. M.
   Polidori, M. Cristina
   Reuter, Martin
   Schulz, Ralf-Joachim
   Vogt, Tobias
   Weber, Bernd
   Kessels, Roy P. C.
   Schneider, Stefan
CA NeuroExercise Study Grp
TI NeuroExercise: The Effect of a 12-Month Exercise Intervention on
   Cognition in Mild Cognitive Impairment-A Multicenter Randomized
   Controlled Trial
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE Alzheimer's disease; non-pharmacological treatment; aerobic exercise;
   cognition; quality of life
ID ALZHEIMERS ASSOCIATION WORKGROUPS; CARDIORESPIRATORY FITNESS;
   OLDER-ADULTS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE;
   PHYSICAL-EXERCISE; DEMENTIA; DISEASE; RECOMMENDATIONS; OUTCOMES
AB Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(-0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [-1.76 (-3.39, -0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO(2)peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations.
C1 [Stuckenschneider, Tim; Abeln, Vera; Schneider, Stefan] German Sport Univ Cologne, Inst Movement & Neurosci, Cologne, Germany.
   [Stuckenschneider, Tim; Schneider, Stefan] Univ Sunshine Coast, Sch Hlth & Sport Sci, VasoAct Res Grp, Maroochydore, Qld, Australia.
   [Sanders, Marit L.; Claassen, Jurgen A. H. R.; Olde Rikkert, Marcel G. M.] Radboud Univ Nijmegen Med Ctr, Dept Geriatr Med, Radboudumc Alzheimer Ctr, Nijmegen, Netherlands.
   [Sanders, Marit L.; Aaronson, Justine A.; Claassen, Jurgen A. H. R.; Olde Rikkert, Marcel G. M.; Kessels, Roy P. C.] Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
   [Devenney, Kate E.; Guinan, Emer] Trinity Coll Dublin, Discipline Physiotherapy, Dublin, Ireland.
   [Aaronson, Justine A.; Kessels, Roy P. C.] Radboud Univ Nijmegen Med Ctr, Dept Med Psychol, Nijmegen, Netherlands.
   [Lawlor, Brian] Trinity Coll Dublin, Mercers Inst Successful Aging, St Jamess Hosp, Dublin, Ireland.
   [Lawlor, Brian] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland.
   [Meeusen, Romain] Vrije Univ Brussel, Dept Human Physiol & Sports Med, Brussels, Belgium.
   [Montag, Christian] Ulm Univ, Inst Psychol & Educ, Dept Mol Psychol, Ulm, Germany.
   [Polidori, M. Cristina] Univ Cologne, Aging Clin Res, Dept Internal Med 2, Cologne, Germany.
   [Polidori, M. Cristina] Univ Cologne, Ctr Mol Med Cologne, Fac Med, Cologne, Germany.
   [Polidori, M. Cristina] Univ Cologne, Univ Hosp Cologne, Cologne, Germany.
   [Reuter, Martin; Weber, Bernd] Univ Bonn, Ctr Econ & Neurosci, Bonn, Germany.
   [Reuter, Martin] Univ Bonn, Dept Psychol, Bonn, Germany.
   [Schulz, Ralf-Joachim] Univ Cologne, Dept Geriatr, Fac Med, Cologne, Germany.
   [Vogt, Tobias] German Sport Univ Cologne, Inst Profess Sport Educ & Sport Qualificat, Cologne, Germany.
   [Vogt, Tobias] Waseda Univ, Fac Sport Sci, Tokorozawa, Saitama, Japan.
C3 German Sport University Cologne; University of the Sunshine Coast;
   Radboud University Nijmegen; Radboud University Nijmegen; Trinity
   College Dublin; Radboud University Nijmegen; Trinity College Dublin;
   Trinity College Dublin; Vrije Universiteit Brussel; Ulm University;
   University of Cologne; University of Cologne; University of Cologne;
   University of Bonn; University of Bonn; University of Cologne; German
   Sport University Cologne; Waseda University
RP Schneider, S (corresponding author), German Sport Univ Cologne, Inst Movement & Neurosci, Cologne, Germany.; Schneider, S (corresponding author), Univ Sunshine Coast, Sch Hlth & Sport Sci, VasoAct Res Grp, Maroochydore, Qld, Australia.
EM schneider@dshs-koeln.de
RI Stuckenschneider, Tim/AAK-1267-2021; Sanders, Marit L/A-2827-2016;
   Abeln, Vera/HNQ-7050-2023; Montag, Christian/H-6536-2019; Kessels, Roy
   P.C./D-1902-2010; Weber, Bernd/H-5244-2012; Claassen, Jurgen
   A.H.R./A-9806-2008
OI Stuckenschneider, Tim/0000-0002-0972-4377; Montag,
   Christian/0000-0001-8112-0837; Kessels, Roy P.C./0000-0001-9500-9793;
   Weber, Bernd/0000-0002-7811-9605; Claassen, Jurgen
   A.H.R./0000-0002-1778-8151; Schulz, Ralf-Joachim/0000-0001-8844-8894;
   Abeln, Vera/0000-0003-4054-438X; Guinan, Emer/0000-0001-9715-146X
FU EU Joint Programme-Neurodegenerative Disease Research (JPND) [BMBF
   01ED1510A]; Health Research Board Ireland [JPND-2014-1, ZonMw
   733051044]; Health Research Board (HRB) [JPND-2014-1] Funding Source:
   Health Research Board (HRB)
FX The project has been supported by The EU Joint
   Programme-Neurodegenerative Disease Research (JPND). JPND had no role in
   study design, data collection and analysis, decision to publish or
   preparation of the manuscript. German Grant Number BMBF 01ED1510A (SS).
   Health Research Board Ireland Grant Number JPND-2014-1 (BL). Dutch Grant
   Number: ZonMw 733051044 (MO).
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NR 60
TC 10
Z9 10
U1 5
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JAN 14
PY 2021
VL 12
AR 621947
DI 10.3389/fnagi.2020.621947
PG 12
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA PY8UH
UT WOS:000612316000001
PM 33519425
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Fong, ZH
   Tan, SH
   Mahendran, R
   Kua, EH
   Chee, TT
AF Fong, Zhi Hui
   Tan, Ser Hong
   Mahendran, Rathi
   Kua, Ee Heok
   Chee, Tji Tjian
TI Arts-based interventions to improve cognition in older persons with mild
   cognitive impairment: A systematic review of randomized controlled
   trials
SO AGING & MENTAL HEALTH
LA English
DT Review
DE Arts; mild cognitive impairment; mild neurocognitive disorder; cognitive
   functioning; systematic review
ID ALZHEIMERS-DISEASE; LEISURE ACTIVITIES; MUSIC-THERAPY; DEMENTIA; ADULTS;
   PEOPLE; RISK
AB Objectives As the global burden of dementia rises, the search for preventive measures such as interventions for mild cognitive impairment (MCI) remains a research priority. While arts-based interventions have demonstrated some success in improving cognitive functioning among older adults and those with dementia, its effectiveness for older persons with MCI remains unexplored. We conducted a systematic review to examine the effects of arts-based interventions on cognition in older persons with MCI. Method The following databases were searched in November 2019: PubMed, EMBASE, PsycINFO, and CINAHL Plus, supplemented by Google Scholar and ALOIS. Study inclusion criteria were older persons aged >= 60 with MCI; arts-based interventions such as dance, drama, music, or visual arts; and randomized controlled trial with cognitive outcome. Database search, study selection, and data extraction were conducted independently by 2 reviewers. Results Eleven randomized controlled trials examining 13 interventions (817 participants) were identified, of which 4 involved visual arts, 4 dance/movement, 3 music, and 2 storytelling. Significant improvement on at least one cognitive outcome was reported in 10 of the 13 interventions. These included improvements in global cognition (6/7 interventions), learning and memory (5/9), complex attention (4/10), executive functioning (2/6), language (2/3), and perceptual-motor function (1/4). Conclusion This review found that arts-based interventions can potentially improve various aspects of cognitive functioning in older persons with MCI, although our confidence was dampened by methodological limitations such as the moderate-to-high risk of bias present in studies and heterogeneity in the way MCI was defined. Recommendations for future research are discussed.
C1 [Fong, Zhi Hui; Tan, Ser Hong; Mahendran, Rathi; Kua, Ee Heok; Chee, Tji Tjian] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
   [Mahendran, Rathi; Kua, Ee Heok; Chee, Tji Tjian] Natl Univ Singapore Hosp, Dept Psychol Med, Singapore, Singapore.
   [Mahendran, Rathi] Duke NUS Med Sch, Acad Dev Dept, Singapore, Singapore.
   [Tan, Ser Hong] Nanyang Technol Univ, Natl Inst Educ, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; Nanyang Technological University &
   National Institute of Education (NIE) Singapore; Nanyang Technological
   University; National Institute of Education (NIE) Singapore
RP Fong, ZH; Chee, TT (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.; Chee, TT (corresponding author), Natl Univ Singapore Hosp, Dept Psychol Med, Singapore, Singapore.
EM pcmfzh@nus.edu.sg; tji_tjian_chee@nuhs.edu.sg
FU National University of Singapore Mind Science Centre
FX This review was supported by grants from the National University of
   Singapore Mind Science Centre, awarded to T.T.
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NR 55
TC 13
Z9 14
U1 6
U2 34
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD AUG 23
PY 2021
VL 25
IS 9
BP 1605
EP 1617
DI 10.1080/13607863.2020.1786802
EA JUL 2020
PG 13
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA UE7VD
UT WOS:000547137400001
PM 32643397
DA 2023-08-17
ER

PT J
AU Lu, YYF
   Bakas, T
   Haase, JE
AF Lu, Yvonne Yueh-Feng
   Bakas, Tamilyn
   Haase, Joan E.
TI Cost Template for Meaningful Activity Intervention for Mild Cognitive
   Impairment
SO CLINICAL NURSE SPECIALIST
LA English
DT Article
DE cognitive impairment; cost; intervention studies
ID CARE; CAREGIVERS; DEMENTIA; THERAPY
AB Purpose:
   The objective of the study was to describe and compare cost estimates for a pilot study of the Daily Enhancement of Meaningful Activity intervention for persons with mild cognitive impairment-caregiver dyads.
   Background:
   The increasing complexity of the healthcare system and rising healthcare costs have forced nurse scientists to find ways to effectively improve healthcare quality and control cost, but no studies have examined costs for new programs that target persons with mild cognitive impairment-caregiver dyads.
   Description of the Project:
   Pilot study data were used to develop a cost template and calculate the cost of implementing the Daily Enhancement of Meaningful Activity.
   Outcomes:
   Mean cost per dyad was estimated to be $1327.97 in the clinical setting, compared with $1069.06 if a telephone delivery mode had been used for 4 of the 6 face-to-face sessions. This difference was largely due to transportation-related expenses and staff cost.
   Implications:
   Daily Enhancement of Meaningful Activity should be evaluated further with larger and more diverse samples as a technology-delivered health promotion program that could reduce costs.
C1 [Lu, Yvonne Yueh-Feng; Bakas, Tamilyn] Indiana Univ, Dept Adult Hlth, Indianapolis, IN 46202 USA.
   [Haase, Joan E.] Indiana Univ, Sch Nursing, Res Palliat & End Of Life Commun & Training RESPE, Dept Family Hlth, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University-Purdue University
   Indianapolis; Indiana University System; Indiana University-Purdue
   University Indianapolis
RP Lu, YYF (corresponding author), Indiana Univ, Sch Nursing, 111 Middle Dr,NU E407, Indianapolis, IN 46202 USA.
EM yuelu@iupui.edu
RI Bakas, Tamilyn/ABC-5664-2020
OI Haase, Joan/0000-0002-8655-9926
FU National Institutes of Health, National Institute of Nursing Research
   [1k01 NR010854-01]
FX Funding was received from the National Institutes of Health, National
   Institute of Nursing Research (1k01 NR010854-01).
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NR 24
TC 2
Z9 2
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0887-6274
EI 1538-9782
J9 CLIN NURSE SPEC
JI Clin. Nurse Spec.
PD MAR-APR
PY 2013
VL 27
IS 2
BP 88
EP 95
DI 10.1097/NUR.0b013e3182819171
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 088YK
UT WOS:000314873600202
PM 23392066
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Perez, A
AF Perez, Adriana
TI Physical Activity and Sleep Patterns in Latinos 55 Years and Older with
   Mild Cognitive Impairment: Baseline Characteristics and Intervention
   Design
SO NURSING RESEARCH
LA English
DT Meeting Abstract
C1 [Perez, Adriana] Univ Penn, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-6562
EI 1538-9847
J9 NURS RES
JI Nurs. Res.
PD MAR-APR
PY 2019
VL 68
IS 2
BP E65
EP E65
PG 1
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HP1RL
UT WOS:000461444300117
DA 2023-08-17
ER

PT J
AU Li, PWC
   Yu, DSF
   Siu, PM
   Wong, SCK
   Chan, BS
AF Li, Polly W. C.
   Yu, Doris S. F.
   Siu, Parco M.
   Wong, Schwinger C. K.
   Chan, Bernice S.
TI Peer-supported exercise intervention for persons with mild cognitive
   impairment: a waitlist randomised controlled trial (the BRAin Vitality
   Enhancement trial)
SO AGE AND AGEING
LA English
DT Article
DE older people; mobile health; volunteers; cognitive function; mild
   cognitive impairment; exercise
ID PHYSICAL-EXERCISE; ALZHEIMERS-DISEASE; OLDER-ADULTS; DECLINE; MEMORY;
   GUIDELINES; ADHERENCE; PROGRAMS; DEFICITS; TESTS
AB Background motivating older people with cognitive impairment to remain physically active is challenging. Objective this study aimed to examine the effects of a peer-supported exercise intervention on the cognitive function and health-related quality of life (HRQoL) of persons with mild cognitive impairment (MCI). Design a two-arm randomised controlled trial. Setting and participants community-dwelling persons with MCI were recruited from community centres for older adults in Hong Kong. Methods participants randomised to the intervention group received an 8-week group-based peer-supported multicomponent exercise intervention, while the waitlist control group received usual care. A battery of neuropsychological tests and the Short Form-36 were administered at baseline, immediately post-intervention and 3 months post-intervention. Results two hundred and twenty-nine participants were randomised to the intervention (n = 116) or control (n = 113) group. Compared with the control group, participants in the intervention group showed significantly greater improvements in processing speed and attention measured by the Colour Trails Test 1 (beta = 7.213, 95% confidence interval [CI] = 2.870-11.557, P = 0.001) and working memory measured by the Digit Span Backward Test (beta = 0.540, 95% CI = 0.199-0.881, P = 0.002) immediately post-intervention. The effects were sustained at 3 months post-intervention. Similarly, significantly greater improvements in sequencing and mental flexibility measured by the Colour Trails Test 2 were observed in the intervention group 3 months post-intervention (beta = 6.979, 95% CI = 3.375-10.584, P < 0.001). Changes in global cognition, short-term memory and HRQoL were not significant. Conclusion the peer-supported exercise intervention was effective at sustaining improvements in executive function, attention and working memory in persons with MCI.
C1 [Li, Polly W. C.; Yu, Doris S. F.; Chan, Bernice S.] Univ Hong Kong, Sch Nursing, LKS Fac Med, Hong Kong, Peoples R China.
   [Siu, Parco M.] Univ Hong Kong, Sch Publ Hlth, LKS Fac Med, Hong Kong, Peoples R China.
   [Wong, Schwinger C. K.] Evangelical Lutheran Church Social Serv, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong
RP Li, PWC (corresponding author), Univ Hong Kong, Sch Nursing, LKS Fac Med, Hong Kong, Peoples R China.
EM pwcli@hku.hk; dyu1@hku.hk; pmsiu@hku.hk; schwingerwong@elchk.org.hk;
   berncs@hku.hk
RI ; Li, Polly/N-9480-2015
OI Chan, Bernice S./0000-0002-9033-4690; Li, Polly/0000-0001-6309-5906
FU Health Care and Promotion Scheme , Food and Health Bureau , Hong Kong
   [01170728]
FX Health Care and Promotion Scheme , Food and Health Bureau , Hong Kong,
   01170728.
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NR 41
TC 0
Z9 0
U1 7
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-0729
EI 1468-2834
J9 AGE AGEING
JI Age Ageing
PD OCT 6
PY 2022
VL 51
IS 10
AR afac213
DI 10.1093/ageing/afac213
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 5C6JH
UT WOS:000864363200003
PM 36201330
DA 2023-08-17
ER

PT J
AU Lu, YYF
   Haase, JE
AF Lu, Yvonne Yueh-Feng
   Haase, Joan E.
TI Content Validity and Acceptability of the Daily Enhancement of
   Meaningful Activity Program: Intervention for Mild Cognitive Impairment
   Patient-Spouse Dyads
SO JOURNAL OF NEUROSCIENCE NURSING
LA English
DT Article
ID ALZHEIMER-DISEASE; PHYSICAL-ACTIVITY; DEMENTIA; RISK; RECRUITMENT;
   PREVALENCE; AWARENESS; MEMORY; REHABILITATION; STRATEGIES
AB Persons with mild cognitive impairment (PwMCI) are at greater risk for developing Alzheimer disease and experience various difficulties that decrease their quality of life. Very few interventions focus on helping PwMCI improve or maintain functional performance and enhance quality of life through meaningful activity engagement. The purpose of the study was to explore PwMCI and their spouses' perspectives on the content validity, usefulness, and acceptability of the Daily Enhancement of Meaningful Activity (DEMA) program, which included 6 biweekly face-to-face sessions between session assignments and a self-management tool kit of written educational handouts. Nine PwMCI-care partner dyads participated in 3 focus groups (PwMCI alone, spouses alone, and couples) to capture their perspectives on DEMA. The transcribed focus group data were analyzed through content analysis. The three groups provided support for content validity and acceptability of the program, and they suggested additional content areas important to couples experiencing MCI. They also attested to the usefulness of the tool kit and gave suggestions for its further improvement. The findings provide evidence of the content validity and acceptability of the DEMA program. A pilot study to assess feasibility and preliminary efficacy of the DEMA on health-related outcomes is the recommended next research step for this program.
C1 [Lu, Yvonne Yueh-Feng] Indiana Univ, Sch Nursing, Dept Adult Hlth Nursing, Indianapolis, IN 46204 USA.
   [Haase, Joan E.] Indiana Univ, Sch Nursing, Dept Pediat Oncol Nursing, Indianapolis, IN 46204 USA.
C3 Indiana University System; Indiana University-Purdue University
   Indianapolis; Indiana University System; Indiana University-Purdue
   University Indianapolis
RP Lu, YYF (corresponding author), Indiana Univ, Sch Nursing, Dept Adult Hlth Nursing, Indianapolis, IN 46204 USA.
EM yuelu@iupui.edu
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NR 61
TC 17
Z9 17
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0888-0395
EI 1945-2810
J9 J NEUROSCI NURS
JI J. Neurosci. Nurs.
PD DEC
PY 2011
VL 43
IS 6
BP 317
EP 328
DI 10.1097/JNN.0b013e318234e9dd
PG 12
WC Clinical Neurology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Nursing
GA 850PL
UT WOS:000297207700006
PM 22089409
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Lee, KT
   Wang, WL
   Lin, WC
   Yang, YC
   Tsai, CL
AF Lee, Kuan-Ting
   Wang, Wei-Li
   Lin, Wen-Chin
   Yang, Yi-Ching
   Tsai, Chia-Liang
TI The Effects of a Magic Intervention Program on Cognitive Function and
   Neurocognitive Performance in Elderly Individuals With Mild Cognitive
   Impairment
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE magic; mild cognitive impairment; executive function; cognition;
   event-related potential (ERP)
ID MINI-MENTAL-STATE; VISUOSPATIAL ATTENTION; INHIBITION; DEMENTIA;
   INTERFERENCE; CONFLICT; MEMORY; ADULTS; MOCA; FMRI
AB ObjectivesCognitive training is one of the management options for elderly individuals who suffer from mild cognitive impairment (MCI) and an effective way to improve executive function. This study aimed to evaluate the effectiveness of a magic intervention program as a method of cognitive training in improving cognitive function and neurocognitive performance in this group. MethodsTwenty-four participants aged 60-80 years with MCI were recruited and randomly assigned to a magic intervention group or a control group. The magic intervention group received a 6-week magic intervention program. The primary endpoints were the scores for the cognitive assessment tests [e.g., Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)] for general cognitive function. The secondary endpoints were the behavioral [e.g., accuracy and reaction times] and the electroencephalographic [e.g., event-related potential (ERP) P3 amplitudes] performance during the Flanker task to assess attention and inhibitory control. All variables were measured before and after the magic intervention. ResultsThe results showed that the 6-week magic intervention significantly improved the MoCA scores in the cognitive assessment tests although no significant pre-post intervention difference was observed in the MMSE scores. In terms of neurocognitive performance, the magic intervention had significantly positive effects on the accuracy, reaction times, and P3 amplitudes when performing the Flanker task. ConclusionThe results of the present study showed that the 6-week magic intervention had beneficial effects on the cognitive and electrophysiological performance in the elderly subjects with MCI. For such a group, lifestyle intervention programs that encourage participation such as the magic practice and performance may be a viable suggestion to prevent the progression of MCI to Alzheimer's disease.
EM yiching@mail.ncku.edu.tw; andytsai@mail.ncku.edu.tw
RI Tsai, Chia-Liang/A-9261-2011
OI Tsai, Chia-Liang/0000-0001-6173-2879; Lee,
   Kuan-Ting/0000-0003-4350-0470; WANG, WEI-LI/0000-0001-5115-7196
FU National Health Research Institute [NHRI-11A1-CG-CO-04-2225-1]
FX We are grateful to the participants and their family caregivers who gave
   their precious time to participate in this research and facilitate the
   work reported here. We also thank the National Health Research Institute
   (#NHRI-11A1-CG-CO-04-2225-1) for the support.
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U1 3
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD APR 13
PY 2022
VL 14
AR 854984
DI 10.3389/fnagi.2022.854984
PG 11
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 1Y4GV
UT WOS:000808100900001
PM 35493940
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Satchidanand, N
AF Satchidanand, N.
TI ThinkFIT: A Community-based, Dual-Task Intervention to Improve Attention
   and Physical Function in Older Adults with Mild Cognitive Impairment
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Meeting Abstract
CT Annual Scientific Meeting of the American-Geriatrics-Society (AGS)
CY MAY 06-09, 2020
CL Long Beach, CA
SP Amer Geriatr Soc
C1 [Satchidanand, N.] Univ Buffalo, Med, Buffalo, NY USA.
C3 State University of New York (SUNY) System; State University of New York
   (SUNY) Buffalo
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD APR
PY 2020
VL 68
SU 1
SI SI
MA C219
BP S257
EP S257
PG 1
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Geriatrics & Gerontology
GA KY5JB
UT WOS:000522602100740
DA 2023-08-17
ER

PT J
AU Liu, C
   Yang, H
   Jiao, YC
   Liu, YY
   Chang, J
   Ji, Y
AF Liu, Chang
   Yang, Hong
   Jiao, Yuchen
   Liu, Yunyue
   Chang, Jing
   Ji, Yan
TI Preferences of people with mild cognitive impairment for physical
   activity interventions in China: protocol for a discrete choice
   experiment study
SO BMJ OPEN
LA English
DT Article
DE protocols & guidelines; dementia; change management; sports medicine
ID OLDER-ADULTS; ACTIVITY PROGRAM; EXERCISE; HEALTH; ADHERENCE; IMPACT;
   MODEL; CARE
AB Introduction Exercise interventions are important non-pharmacological interventions for patients with mild cognitive impairment (MCI), but patients with MCI have poor compliance and there is no consistent strategy for exercise interventions. Understanding the needs and preferences of MCI patients allows for the development of effective and acceptable exercise intervention programmes that achieve the goals of patient-centred care. This study uses a discrete choice experiment (DCE) to measure and quantify MCI patients' preferences for exercise interventions, and aims at (1) identifying and exploring which elements of exercise intervention programmes are essential for MCI patients; (2) measuring MCI patients' preferences for exercise interventions and summarising relevant characteristics that may influence preference choices and (3) determining whether these preferences vary by participant characteristics and classifying the population types based on the sociodemographic characteristics of the participants. Methods and analysis A DCE will be conducted to explore MCI patients' preferences for exercise interventions. We conducted a systematic literature review and extensive qualitative work to select the best attributes to develop the design of DCE. A partial factorial survey design was generated through an orthogonal experimental design. We will conduct a questionnaire survey in one city each in the eastern (Nanjing), western (Xining), southern (Zhuhai) and northern (Beijing) parts of China and reach the planned sample size (n=278). Final data will be analysed using a mixed logit model and a latent class model. Ethics and dissemination This study was approved by the Ethics Committee of Nanjing Medical University (2021-666). All participants will be required to provide informed consent. Our findings will be disseminated and shared with interested patient groups and the general public through online blogs, policy briefs, national and international conferences and peer-reviewed journals.
C1 [Liu, Chang; Jiao, Yuchen; Liu, Yunyue; Chang, Jing; Ji, Yan] Nanjing Med Univ, Sch Nursing, Nanjing, Peoples R China.
   [Yang, Hong] Peking Union Med Coll Hosp, Dept Gen Surg, Beijing, Peoples R China.
C3 Nanjing Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College Hospital
RP Ji, Y (corresponding author), Nanjing Med Univ, Sch Nursing, Nanjing, Peoples R China.
EM yanji@njmu.edu.cn
RI jiao, yuchen/H-6313-2011
OI Liu, Chang/0000-0001-7950-1630
FU National Natural Science Foundation of China [72204122]; 'Nursing'
   project of superior discipline construction in Jiangsu Universities [87]
FX y This work was supported by National Natural Science Foundation of
   China (72204122) and 'Nursing' project of superior discipline
   construction in Jiangsu Universities (szbf [2018] No. 87).
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NR 32
TC 0
Z9 0
U1 1
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD OCT
PY 2022
VL 12
IS 10
AR e064153
DI 10.1136/bmjopen-2022-064153
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5K0CV
UT WOS:000869403600024
PM 36241356
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Huang, XX
   Zhao, XY
   Cai, Y
   Wan, QQ
AF Huang, Xiuxiu
   Zhao, Xiaoyan
   Cai, Ying
   Wan, Qiaoqin
TI The cerebral changes induced by exercise interventions in people with
   mild cognitive impairment and Alzheimer's disease: A systematic review
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Review
DE Cognitive impairment; Exercise; Neuroimaging; Electroencephalography;
   Systematic review
ID FUNCTIONAL BRAIN NETWORKS; DEFAULT MODE NETWORK; PHYSICAL-EXERCISE;
   BLOOD-FLOW; INDIVIDUALS
AB Objectives: This study aimed to summarize the effects of exercise on the brain structure and function measured by imaging and electroencephalography methods in people with mild cognitive impairment and Alzheimer's disease. Methods: We systematically searched different electronic databases, including PubMed, Web of Science, Embase, Cochrane Central Register of controlled trials, SPORTDiscus, PsycINFO up to September 2021. Randomized controlled trials with exercise interventions in people with mild cognitive impairment and Alzheimer's disease were included. The outcomes included all the structural and functional brain changes measured by neuroimaging and electroencephalography approaches. All the outcomes were summarized and tabulated. The protocol has been registered on the PROSPERO (CDR42020192579). Results: Nineteen articles from 12 trials were included. Most studies focused on people with mild cognitive impairment and revealed positive effects on the volumes of hippocampus and cingulate cortex, the resting state functional connectivity between the hippocampus and other brain regions, the brain activity in several regions, the cerebral blood flow, electroencephalogram, and P300 latency and amplitude. Different types of exercise could produce distinct effects and intensity was a factor affecting the effects of aerobic and resistance exercise interventions. Meanwhile, limited studies paid attention to people with Alzheimer's disease and showed insignificant results. Conclusions: Exercise has positive effects on the brain structures and functions in people with mild cognitive impairment, while for people with Alzheimer's disease, limited studies revealed insignificant effects.
C1 [Huang, Xiuxiu; Zhao, Xiaoyan; Cai, Ying; Wan, Qiaoqin] Peking Univ, Sch Nursing, 38 Xueyuan Rd, Beijing 100191, Peoples R China.
C3 Peking University
RP Wan, QQ (corresponding author), Peking Univ, Sch Nursing, 38 Xueyuan Rd, Beijing 100191, Peoples R China.
EM qqwan05@163.com
RI Huang, Xiuxiu/AAM-4920-2021
OI Huang, Xiuxiu/0000-0002-5065-9087
FU National Natural Science Foundation of China [81,871,854]
FX This research was founded by the National Natural Science Foundation of
   China (81,871,854) . The sponsor had no any involvement in this study.
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NR 52
TC 4
Z9 4
U1 2
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD JAN-FEB
PY 2022
VL 98
AR 104547
DI 10.1016/j.archger.2021.104547
EA OCT 2021
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA WK4XM
UT WOS:000709730200002
PM 34634494
DA 2023-08-17
ER

PT J
AU Liang, JH
   Xu, Y
   Lin, L
   Jia, RX
   Zhang, HB
   Hang, L
AF Liang, Jing-hong
   Xu, Yong
   Lin, Lu
   Jia, Rui-xia
   Zhang, Hong-bo
   Hang, Lei
TI Comparison of multiple interventions for older adults with Alzheimer
   disease or mild cognitive impairment: A PRISMA-compliant network
   meta-analysis
SO MEDICINE
LA English
DT Review
DE Alzheimer disease; cognitive interventions; mild cognitive impairment;
   network meta-analysis
ID ESTROGEN REPLACEMENT THERAPY; EXERCISE PROGRAM; ELDERLY-PATIENTS;
   MUSIC-THERAPY; DEMENTIA; EFFICACY; PEOPLE; PSYCHOTHERAPY; STIMULATION;
   SYMPTOMS
AB Background:The increasing prevalence of Alzheimer disease (AD) emphasizes the need for effective treatments. Both pharmacological therapies such as nutrition therapy (NT) and nonpharmacologic therapies including traditional treatment or personalized treatment (e.g., physical exercise, music therapy, computerized cognitive training) have been approved for the treatment of AD or mild cognitive impairment (MCI) in numerous areas.Methods:The aim of this study was to compare 4 types of interventions, physical exercise (PE), music therapy (MT), computerized cognitive training (CCT), and NT, in older adults with mild to moderate AD or MCI and identify the most effective intervention for their cognitive function. We used a system of search strategies to identify relevant studies and include randomized controlled trials (RCTs), placebo-controlled trials evaluating the efficacy and safety of 4 interventions in patients with AD or MCI. We updated the relevant studies which were published before March 2017 as a full-text article. Using Bayesian network meta-analysis (NMA), we ranked cognitive ability based objectively on Mini-Mental State Examination (MMSE), and assessed neuropsychiatric symptoms based on Neuropsychiatric Inventory (NPI). Pairwise and network meta-analyses were sequentially performed for efficacy and safety of intervention compared to control group through RCTs included.Results:We included 17 RCTs. Fifteen trials (n=1747) were pooled for cognition and no obvious heterogeneity was found (I-2=21.7%, P=.212) in NMA, the mean difference (MD) of PE (MD=2.1, confidence interval [CI]: 0.44-3.8) revealed that PE was significantly efficacious in the treatment group in terms of MMSE. Five trials (n=660) assessed neuropsychiatric symptoms with an obvious heterogeneity (I-2=61.6%, P=.034), the MD of CCT (MD=-7.7, CI: -14 to -2.4), revealing that CCT was significantly efficacious in NPI.Conclusions:As the first NMA comparing different interventions for AD and MCI, our study suggests that PE and CCT might have a significant improvement in cognition and neuropsychiatric symptoms respectively. Moreover, nonpharmacological therapies might be better than pharmacological therapies.
C1 [Liang, Jing-hong; Xu, Yong; Jia, Rui-xia; Zhang, Hong-bo; Hang, Lei] Soochow Univ, Sch Publ Hlth, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, Dept Child Hlth, Suzhou, Peoples R China.
   [Lin, Lu] Soochow Univ, Coll Med, Sch Nursing, Suzhou, PR, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Xu, Y (corresponding author), Soochow Univ, Sch Publ Hlth, Coll Med, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.
EM childhealth@suda.edu.cn
RI Lin, Lu/AAZ-3475-2021; Liang, Jinghong/AAE-7171-2022
OI Lin, Lu/0000-0002-2049-4605; Liang, Jinghong/0000-0001-9237-7291
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NR 74
TC 60
Z9 66
U1 5
U2 83
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY
PY 2018
VL 97
IS 20
AR e10744
DI 10.1097/MD.0000000000010744
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GI3XR
UT WOS:000434305900029
PM 29768349
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Lyu, QY
   Cheung, DSK
   Lai, HL
   Wang, XM
   Qiu, J
   Huang, YQ
   Zeng, YC
AF Lyu, Qiyuan
   Cheung, Daphne S. K.
   Lai, Huilan
   Wang, Xiaomeng
   Qiu, Jing
   Huang, Yuanqiu
   Zeng, Yingchun
TI A multicomponent integrative intervention to slow down the progression
   of mild cognitive impairment: A protocol for a randomized controlled
   trial
SO RESEARCH IN NURSING & HEALTH
LA English
DT Article
DE cognitive function; dementia; quality of life; randomized controlled
   trial
ID QUALITY-OF-LIFE; SCALE GDS-15; DEMENTIA; INDIVIDUALS; EXERCISE;
   VALIDATION; VALIDITY; SAMPLE; ADULTS
AB Mild cognitive impairment affects 36% of people aged 65 years and over in China, and around 50% transition from mild cognitive impairment to dementia within 3 years. Early intervention can slow down disease progression and thus delay dementia onset. The purpose of this article is to outline the protocol of an ongoing randomized controlled trial in mainland China that will evaluate the effects and feasibility of a 6-month multicomponent integrative intervention on the speed of progression of mild cognitive impairment to dementia. Ninety-six community-dwelling older adults, aged 65 years and older, will be recruited (recruitment will be completed in May 2020), using strict inclusion/exclusion criteria, from two community health service centers in Guangzhou, Guangdong province. Participants will be allocated to receive either the multicomponent integrative intervention or usual care. The core components of the intervention are cognitive training, dietary instruction, physical activity, and management of vascular risk factors. Data are collected at the beginning of the study, then at 1, 3, and 6 months. The primary outcome is cognitive function. The main secondary outcomes are exercise capacity, comprehensive physical capacity, depression, and quality of life. An intention-to-treat analysis will be conducted. The study will be completed in 2021. The multicomponent integrative intervention detailed in this protocol could be incorporated into dementia prevention programs in community health service centers, or other similar settings, to delay the onset of dementia.
C1 [Lyu, Qiyuan] Jinan Univ, Sch Nursing, Guangzhou, Peoples R China.
   [Cheung, Daphne S. K.] Hong Kong Polytech Univ, Sch Nursing, Guangzhou, Peoples R China.
   [Lai, Huilan; Wang, Xiaomeng; Qiu, Jing; Huang, Yuanqiu] Peoples St Community Hlth Serv Ctr, Dept Nursing, Guangzhou, Peoples R China.
   [Zeng, Yingchun] Guangzhou Med Univ, Affiliated Hosp 3, Res Inst Gynecol & Obstet, Guangzhou 510150, Guangdong, Peoples R China.
C3 Jinan University; Hong Kong Polytechnic University; Guangzhou Medical
   University
RP Zeng, YC (corresponding author), Guangzhou Med Univ, Affiliated Hosp 3, Res Inst Gynecol & Obstet, Guangzhou 510150, Guangdong, Peoples R China.
EM chloezengyc@hotmail.co.uk
RI Cheung, Daphne Sze Ki/M-4528-2015; Cheung, Daphne Sze Ki/AAY-2152-2020;
   Zeng, Yingchun/AAI-9775-2021
OI Cheung, Daphne Sze Ki/0000-0001-5651-9352; Cheung, Daphne Sze
   Ki/0000-0001-5651-9352; Zeng, Yingchun/0000-0001-9250-4086
FU Natural Science Foundation of Guangdong Province of China
   [2019A1515011672]; Fundamental Research Funds for the Central
   Universities [N2017Y05]; National Natural Science Foundation of China
   [71804204]
FX Natural Science Foundation of Guangdong Province of China, Grant/Award
   Number: 2019A1515011672; Fundamental Research Funds for the Central
   Universities, Grant/Award Number: N2017Y05; National Natural Science
   Foundation of China, Grant/Award Number: 71804204
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NR 41
TC 1
Z9 1
U1 5
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-6891
EI 1098-240X
J9 RES NURS HEALTH
JI Res. Nurs. Health
PD AUG
PY 2020
VL 43
IS 4
BP 307
EP 316
DI 10.1002/nur.22050
EA JUL 2020
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA ML4WZ
UT WOS:000545345800001
PM 32627231
DA 2023-08-17
ER

PT J
AU Li, FZ
   Harmer, P
   Fitzgerald, K
   Winters-Stone, K
AF Li, Fuzhong
   Harmer, Peter
   Fitzgerald, Kathleen
   Winters-Stone, Kerri
TI A cognitively enhanced online Tai Ji Quan training intervention for
   community-dwelling older adults with mild cognitive impairment: A
   feasibility trial
SO BMC GERIATRICS
LA English
DT Article
DE Cognitive impairment; Dual-task; Elderly; Exercise; Tai Chi; Telehealth
ID DUAL-TASK; PREVENTION INTERVENTION; HEALTH; CHI; PERFORMANCE; EXERCISE;
   DISEASE; BRAIN
AB Background: This study examines the feasibility, acceptability, and safety of a newly developed cognitive-enhancing Tai Ji Quan training intervention, delivered via remote videoconferencing, for older adults with mild cognitive impairment (MCI).
   Methods: In a three-arm feasibility trial, community-dwelling older adults with MCI (N = 69; mean age = 74.6 years, 57% women) were randomized to a cognitively enhanced Tai Ji Quan (n = 23), standard Tai Ji Quan (n = 22), or stretching group (n = 24) and participated in a 60-minute online exercise session via Zoom, twice weekly for 16 weeks. Participants were recruited primarily in the state of Oregon through mass mailing and word of mouth. The primary outcomes were intervention feasibility (with respect to recruitment, online intervention delivery, fidelity and compliance, and attrition and retention rates), acceptability, and safety. We also assessed feasibility of online data collection and test-retest reliability and explored preliminary trends on secondary outcomes that included global cognitive function, dual-task cost, and domain-specific cognition function.
   Results: The study had an average recruitment rate of 55%. Feasibility was demonstrated by the overall successful online program implementation, with good fidelity, acceptable compliance (76%), and excellent retention (94%). The cognitively enhanced Tai Ji Quan intervention was shown to be acceptable to participants as well as safe, with no major intervention-related moderate/severe events. At week 16, the group receiving cognitively enhanced Tai Ji Quan training showed a positive trend in the cognitive function and dual-task outcome measures whereas the group receiving standard Tai Ji Quan training exhibited positive trends on global and domain-specific cognitive measures.
   Conclusions: Preliminary findings of this pilot study indicate the feasibility, acceptability, and safety of a tailored, cognitively enhanced Tai Ji Quan training intervention delivered remotely to home settings via videoconferencing for community-dwelling older adults with MCI.
C1 [Li, Fuzhong] Oregon Res Inst, Eugene, OR 97403 USA.
   [Harmer, Peter] Willamette Univ, Dept Exercise & Hlth Sci, Salem, OR 97301 USA.
   [Fitzgerald, Kathleen] McKenzie Willamette Med Ctr, Springfield, OR 97477 USA.
   [Winters-Stone, Kerri] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97239 USA.
C3 Oregon Research Institute; Willamette University; Oregon Health &
   Science University
RP Li, FZ (corresponding author), Oregon Res Inst, Eugene, OR 97403 USA.
EM fuzhongl@ori.org
FU National Institute on Aging [3R01AG059546-02S1]
FX The study reported in this manuscript was supported by the National
   Institute on Aging (3R01AG059546-02S1). The opinions expressed are those
   of the authors and do not necessarily represent the official views of
   the National Institute on Aging.
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NR 46
TC 14
Z9 15
U1 9
U2 26
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD JAN 25
PY 2022
VL 22
IS 1
AR 76
DI 10.1186/s12877-021-02747-0
PG 13
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA YQ3RJ
UT WOS:000749229100001
PM 35078407
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Ba, HM
   Kim, J
AF Mai Ba, Hai
   Kim, Jiyun
TI The Effects of Combined Physical and Cognitive Interventions on Direct
   and Indirect Fall Outcomes for the Elderly with Mild Cognitive
   Impairment: A Systematic Review
SO HEALTHCARE
LA English
DT Review
DE cognitive therapy; elderly; falls; mild cognitive impairment; physical
   training
ID OLDER-ADULTS; EXERCISE PROGRAM; VIRTUAL-REALITY; RISK; IMPROVE;
   COMBINATION; HEALTHY; DECLINE; BALANCE; SENIORS
AB This review was intended to determine the effectiveness of physical and cognitive training (PCT) on falls and fall-related factors and cognitive function among community-dwelling elderly people with mild cognitive impairment (MCI). A systematic literature search was performed of the MEDLINE, CINAHL, Web of Sciences, Scopus, ProQuest, Embase, and Google Scholar databases for articles published from 2010 to 2020. The studies that combined PCT to assess their impacts on fall outcomes both directly and indirectly were included. Study quality was assessed using the standardized JBI Critical Appraisal Tool for RCTs. The standardized data extraction tool from JBI-MAStARI was used to extract data of included studies. Seven RCTs involving 740 participants were included. The overall fall incidence did not significantly decrease after the interventions. However, PCT significantly impacted the cognitive function and physical activities of elderly people with MCI, particularly improving their balancing ability, gait speed, muscular strength, and executive functions. This study indicated that combining PCT improves balance ability, gait speed, and executive functioning in the elderly with MCI, which may help to minimize fall occurrence.
C1 [Mai Ba, Hai] Hue Univ, Hue Univ Med & Pharm, Fac Nursing, Hue 49000, Vietnam.
   [Kim, Jiyun] Gachon Univ, Sch Nursing, Incheon 21936, South Korea.
C3 Hue University; Gachon University
RP Kim, J (corresponding author), Gachon Univ, Sch Nursing, Incheon 21936, South Korea.
EM mbhai@huemed-univ.edu.vn; jkim@gachon.ac.kr
RI Kim, Jiyun/ADP-0374-2022
OI Kim, Jiyun/0000-0001-5182-0242; Mai Ba, Hai/0000-0002-1987-5697
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [2020R1F1A1076167]; National Research Foundation of Korea
   [2020R1F1A1076167] Funding Source: Korea Institute of Science &
   Technology Information (KISTI), National Science & Technology
   Information Service (NTIS)
FX This work was supported by the National Research Foundation of Korea
   (NRF), grant funded by the Korea government (MSIT) (No.
   2020R1F1A1076167).
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NR 68
TC 2
Z9 2
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAY
PY 2022
VL 10
IS 5
AR 862
DI 10.3390/healthcare10050862
PG 17
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 1P2XB
UT WOS:000801876900001
PM 35628001
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Wang, R
   Zhang, HY
   Li, HJ
   Ren, H
   Sun, TT
   Xu, LY
   Liu, Y
   Hou, X
AF Wang, Rong
   Zhang, Hanyue
   Li, Hongjuan
   Ren, Hong
   Sun, Tingting
   Xu, Liya
   Liu, Yang
   Hou, Xiao
TI The influence of exercise interventions on cognitive functions in
   patients with amnestic mild cognitive impairment: A systematic review
   and meta-analysis
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE exercise; cognitive function; mild cognitive impairment; amnestic;
   meta-analysis; physical activity
ID OLDER-ADULTS; CHOLINESTERASE-INHIBITORS; AEROBIC EXERCISE; TAI CHI;
   NEUROGENESIS; ACTIVATION; DEMENTIA; HIPPOCAMPUS; PERFORMANCE; CONVERSION
AB Introduction: Patients with amnestic mild cognitive impairment (aMCI) are more likely to develop dementia compared to patients with non-aMCI (naMCI). Among the mixed samples of aMCI and naMCI, exercise interventions are effective for patients with MCI to improve cognitive functions. However, the influence of exercise interventions on patients with aMCI is still unclear. Objective: The objective of this systematic review and meta-analysis is to evaluate the influence of exercise interventions on cognitive functions in patients with aMCI. Methods: Four literature databases (PubMed, Web of Science, EBSCO, and Cochrane Library) and three Chinese databases (China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Database) were searched from their inception to August 31, 2022. Based on the preliminary search of seven databases and their cited references, a total of 2,290 records were identified. Finally, 10 studies with a total of 28 data points involving 575 participants with aMCI were included in this meta-analysis. If the measurements of outcomes were different among studies, the effect size was synthesized using the standardized mean difference (SMD) with a 95% confidence interval (CI). If the measurements were the same, the weight mean difference (WMD) with a 95% CI was used to integrate the effect size. Data synthesis: The results showed that exercise interventions had no significant effects on improving several specific domains of cognitive functions including working memory (WMD = -0.05; 95% CI = -0.74 to 0.63; p = 0.88; I-2 = 78%) and attention (SMD = 0.20; 95% CI = -0.31 to 0.72; p = 0.44; I-2 = 60%). Additionally, exercise interventions had a significant effect on global cognitive function (SMD = 0.70; 95% CI = 0.50-0.90; p < 0.00001; I-2 = 29%) and some specific cognitive domains including immediate recall (SMD = 0.55; 95% CI = 0.28-0.81; p < 0.0001; I-2 = 0%), delayed recall (SMD = 0.66; 95% CI = 0.45-0.87; p < 0.00001; I-2 = 37%), and executive function (SMD = 0.38; 95% CI = 0.16-0.60; p= 0.0006; I-2 = 4%). Furthermore, subgroup analysis based on the intervention forms indicated that multi-component interventions (SMD = 0.44; 95% CI = 0.11-0.77; p = 0.009; I-2 = 0%) appeared to be less effective than the single-component intervention (SMD = 0.85; 95% CI = 0.60-1.10; p < 0.00001; I-2 = 10%) in terms of boosting global cognitive function. Conclusion: This meta-analysis suggests that the exercise can help patients with aMCI improve global cognitive function. And exercise interventions have positive influence on enhancing several specific cognitive domains such as immediate recall, delayed recall, and executive function.
C1 [Wang, Rong; Li, Hongjuan; Ren, Hong; Xu, Liya; Hou, Xiao] Beijing Sport Univ, Sch Sport Sci, Dept Phys Fitness & Hlth, Beijing, Peoples R China.
   [Zhang, Hanyue; Sun, Tingting; Xu, Liya; Hou, Xiao] Beijing Sport Univ, Key Lab Sports & Phys Hlth, Minist Educ, Beijing, Peoples R China.
   [Zhang, Hanyue] Northeast Normal Univ, Sch Phys Educ, Changchun, Peoples R China.
   [Liu, Yang] Shandong Jianzhu Univ, Dept Phys Educ, Jinan, Peoples R China.
C3 Beijing Sport University; Beijing Sport University; Northeast Normal
   University - China; Shandong Jianzhu University
RP Hou, X (corresponding author), Beijing Sport Univ, Sch Sport Sci, Dept Phys Fitness & Hlth, Beijing, Peoples R China.; Hou, X (corresponding author), Beijing Sport Univ, Key Lab Sports & Phys Hlth, Minist Educ, Beijing, Peoples R China.
EM houxiao0327@bsu.edu.cn
RI Xu, Liya/AAV-5387-2021; Hou, Xiao/HIR-3041-2022
FU Fundamental Research Funds for the Central Universities;  [2015YB002]
FX Funding This study was supported by the Fundamental Research Funds for
   the Central Universities (Grant Number: 2015YB002).
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NR 66
TC 2
Z9 2
U1 3
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD NOV 15
PY 2022
VL 10
AR 1046841
DI 10.3389/fpubh.2022.1046841
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 6Q7VY
UT WOS:000891820200001
PM 36457329
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Brydges, CR
   Liu-Ambrose, T
   Bielak, AAM
AF Brydges, Christopher R.
   Liu-Ambrose, Teresa
   Bielak, Allison A. M.
TI Using Intraindividual Variability as an Indicator of Cognitive
   Improvement in a Physical Exercise Intervention of Older Women With Mild
   Cognitive Impairment
SO NEUROPSYCHOLOGY
LA English
DT Article
DE intraindividual variability; aging; mild cognitive impairment;
   intervention; cognitive change
ID WITHIN-PERSON VARIABILITY; AEROBIC EXERCISE; EXECUTIVE FUNCTIONS;
   TASK-DIFFICULTY; ADULTS; PERFORMANCE; METAANALYSIS; INCREASES; DEMENTIA;
   MEMORY
AB Objectives: Intervention programs designed to improve cognitive ability in older adults with mild cognitive impairment (MCI) have often focused on physical exercise as a means to improve traditional measures of cognition, with mixed success. Individuals with MCI show high levels of intraindividual variability (IIV) in response speed, and IN may be sensitive to intervention-related changes. The current study evaluated if participants who participated in a physical activity intervention (aerobic or resistance training) showed a reduction in IIV, compared to a balance and tone control group. Method: This study was a secondary analysis of the EXercise for Cognition and Everyday living (EXCEL) Study. Women Aged 70-80 years with probable MCI (n = 86) participated in a 6-month randomized controlled trial designed to investigate the effects of different physical exercises on cognitive ability. Participants completed 1-back, task switching, and spatial working memory tasks at baseline, 13 weeks (midpoint) and upon completion of the program. Results: Analyses were conducted following both the intent-to-treat principle and complier average casual effect (CACE) modeling. Participants in the intervention group who complied with the program showed reduced IIV on task switching in the CACE models. The intent-to-treat analyses were all nonsignificant. Conclusions: Physical exercise resulted in improved IIV in older adults with probable MCI, showing that IIV is modifiable by lifestyle engagement. IIV may be a useful complementary index of cognitive plasticity particularly among those with cognitive impairment.
C1 [Brydges, Christopher R.; Bielak, Allison A. M.] Colorado State Univ, Dept Human Dev & Family Studies, 1570 Campus Delivery, Ft Collins, CO 80523 USA.
   [Liu-Ambrose, Teresa] Univ British Columbia, Vancouver Coastal Res Inst, Dept Phys Therapy, Vancouver, BC, Canada.
C3 Colorado State University; University of British Columbia; Vancouver
   Coastal Health Research Institute
RP Brydges, CR (corresponding author), Colorado State Univ, Dept Human Dev & Family Studies, 1570 Campus Delivery, Ft Collins, CO 80523 USA.
EM chris.hrydges@colostate.edu
RI Bielak, Allison A. M./H-2388-2012
OI Bielak, Allison A. M./0000-0003-2925-0372; Brydges,
   Christopher/0000-0001-5901-638X
FU National Institutes of Health [R03AG055748, R03AG055748-01S1]; Pacific
   Alzheimer's Research Foundation
FX This work was supported by the National Institutes of Health (Grants
   R03AG055748 and R03AG055748-01S1 to AAMB). The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health. The Pacific
   Alzheimer's Research Foundation provided funding for the EXercise for
   Cognition and Everyday Living (EXCEL) Study to TLA. Teresa Liu-Ambrose
   is a Canada Research Chair (Tier 2) in Physical Activity, Mobility, and
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NR 67
TC 2
Z9 2
U1 2
U2 11
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
EI 1931-1559
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD NOV
PY 2020
VL 34
IS 8
BP 825
EP 834
DI 10.1037/neu0000638
PG 10
WC Psychology, Clinical; Neurosciences; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA OW2JR
UT WOS:000592720400001
PM 32338944
OA Green Accepted, Bronze
DA 2023-08-17
ER

PT J
AU Rodakowski, J
   Reynolds, CF
   Lopez, OL
   Butters, MA
   Dew, MA
   Skidmore, ER
AF Rodakowski, Juleen
   Reynolds, Charles F., III
   Lopez, Oscar L.
   Butters, Meryl A.
   Dew, Mary Amanda
   Skidmore, Elizabeth R.
TI Developing a Non-Pharmacological Intervention for Individuals With Mild
   Cognitive Impairment
SO JOURNAL OF APPLIED GERONTOLOGY
LA English
DT Article
DE strategy training; non-pharmacological intervention; mild cognitive
   impairment; dementia; cognition
ID SELF-IDENTIFIED GOALS; LATE-LIFE FUNCTION; OLDER-ADULTS; DEPRESSION;
   EXERCISE; METAANALYSIS; PERFORMANCE; VERSION; MEMORY
AB The purpose of this study is to describe one potential intervention model that is designed to slow decline to disability for individuals at-risk for dementia due to Mild Cognitive Impairment. Strategy training is a treatment model that focuses on behavioral activation through addressing barriers to daily activities. Strategy training encourages development of goals and plans to address self-identified impaired processes, and it maintains or improves individuals' ability to perform desired activities. Progression to dementia may be slowed due to the link between engagement in daily activities and production of biological factors associated with neurocognitive health. We demonstrated that an older adult with mild cognitive impairment is able to develop goals, establish effective plans, and engage in daily activities through the strategy training intervention model.
C1 [Rodakowski, Juleen; Skidmore, Elizabeth R.] Univ Pittsburgh, Occupat Therapy, Pittsburgh, PA USA.
   [Reynolds, Charles F., III; Butters, Meryl A.; Dew, Mary Amanda] Univ Pittsburgh, Psychait, Pittsburgh, PA USA.
   [Lopez, Oscar L.] Univ Pittsburgh, Neurol, Pittsburgh, PA USA.
   [Lopez, Oscar L.] Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Rodakowski, J (corresponding author), Univ Pittsburgh, Dept Occupat Therapy, 5012 Forbes Tower, Pittsburgh, PA 15260 USA.
EM Jur17@pitt.edu
RI Rodakowski, Juleen/J-3536-2019; Butters, Meryl/AAR-2863-2021
OI Rodakowski, Juleen/0000-0002-6397-8124; 
FU National Institutes of Health [KL2 TR000146, P30 MH090333, P50 AG05133,
   UL1 TR000005]; UPMC Endowed Chair in Geriatric Psychiatry
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by the National Institutes of Health under grant numbers KL2
   TR000146, P30 MH090333, P50 AG05133, UL1 TR000005, and the UPMC Endowed
   Chair in Geriatric Psychiatry.
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NR 46
TC 10
Z9 10
U1 6
U2 35
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0733-4648
EI 1552-4523
J9 J APPL GERONTOL
JI J. Appl. Gerontol.
PD MAY
PY 2018
VL 37
IS 5
SI SI
BP 665
EP 676
DI 10.1177/0733464816645808
PG 12
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GC5VQ
UT WOS:000429858700007
PM 27106884
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Liu, XY
   Wang, GP
   Cao, YJ
AF Liu, Xueyan
   Wang, Guangpeng
   Cao, Yingjuan
TI Association of nonpharmacological interventions for cognitive function
   in older adults with mild cognitive impairment: a systematic review and
   network meta-analysis
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Review
DE Mild cognitive impairment; MCI; Nonpharmacological interventions;
   Elderly; Systematic review; Network meta-analysis
ID ACUPRESSURE; DEMENTIA; QUALITY; STRESS
AB Background Understanding the effectiveness of nonpharmacological interventions to improve cognitive function in older adults with MCI and identifying the best intervention may help inform ideas for future RCT studies and clinical decision-making.Aim The main focus of this study was to assess the comparative effectiveness of nonpharmacological interventions on cognitive function in older adults with MCI and to rank the interventions.Methods RCT studies until September 2022 were searched from six databases, including PubMed, the Cochrane Library, Embase, Web of Science, PsycINFO and CINAHL. The risk of bias in eligible trials was evaluated using the Cochrane Risk of Bias tool. Both pairwise and network meta-analyses were used, and pooled effect sizes were reported using SMD and the corresponding 95% confidence intervals.Results A total of 28 RCT studies were included in this study, pooling 18 categories of nonpharmacological interventions. MBE (mind-body exercise) (SMD (standard mean difference): 0.24, 95% CI: 0.08-0.41, P= 0.004), DTE (dual-task exer-cise) (SMD: 0.61, 95% CI: 0.09-1.13, P= 0.02), PE (physical exercise) (SMD: 0.58, 95% CI: 0.04-1.12, P = 0.03) may be effective in improving cognitive function in older adults with MCI. Acupressure + CT (cognitive training) was the top-ranked intervention among all interventions. No greater benefits of MA (mindful awareness) on cognitive function were found.Conclusions Overall, nonpharmacological interventions significantly improved cognitive function in older adults with MCI. Acupressure + CT(cognitive training) was the most effective intervention for managing cognitive impairment. Future studies with high quality and large sample size RCT studies are needed to confirm our results.
C1 [Liu, Xueyan] Shandong Univ, Cheeloo Coll Med, Sch Nursing & Rehabil, 44 Wenhuaxi Rd, Jinan, Shandong, Peoples R China.
   [Wang, Guangpeng] Cent South Univ, Xiangya Sch Nursing, 172 Tongzipo Rd, Changsha, Hunan, Peoples R China.
   [Cao, Yingjuan] Shandong Univ, Qilu Hosp, Dept Nursing, 107 Wenhuaxi Rd, Jinan, Shandong, Peoples R China.
C3 Shandong University; Central South University; Shandong University
RP Cao, YJ (corresponding author), Shandong Univ, Qilu Hosp, Dept Nursing, 107 Wenhuaxi Rd, Jinan, Shandong, Peoples R China.
EM caoyj@sdu.edu.cn
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NR 65
TC 2
Z9 2
U1 3
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD MAR
PY 2023
VL 35
IS 3
BP 463
EP 478
DI 10.1007/s40520-022-02333-3
EA JAN 2023
PG 16
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 9V7NI
UT WOS:000909164500001
PM 36607554
DA 2023-08-17
ER

PT J
AU Gomez-Soria, I
   Marin-Puyalto, J
   Peralta-Marrupe, P
   Latorre, E
   Calatayud, E
AF Gomez-Soria, Isabel
   Marin-Puyalto, Jorge
   Peralta-Marrupe, Patricia
   Latorre, Eva
   Calatayud, Estela
TI Effects of multi-component non-pharmacological interventions on
   cognition in participants with mild cognitive impairment: A systematic
   review and meta-analysis
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Review
DE Cognitive training; Cognitive rehabilitation; Cognitive stimulation;
   Cognitive intervention; Physical training; Mini-mental state examination
ID ALZHEIMERS-DISEASE; OLDER-ADULTS; PEDRO SCALE; DEMENTIA; EFFICACY;
   QUALITY; HEALTHY; PEOPLE; RISK
AB Background and purpose: Mild cognitive impairment (MCI) describes a stage of intermediate cognitive dysfunction where the risk of conversion to dementia is elevated. Given the absence of effective pharmacological treatments for MCI, increasing numbers of studies are attempting to understand how multicomponent non-pharmacological interventions (MNPI) could benefit MCI. The purpose of this systematic review and meta-analysis were to assess the effects of two-component MNPI (simultaneous cognitive intervention based on cognitive stimulation, cognitive training and/or cognitive rehabilitation or combined cognitive and physical interventions) on global cognition and cognitive functions in older adults with MCI and to compare the degree of efficacy between the two interventions.
   Methods: After searching electronic databases (PubMed, Web of Science, Scopus and Cochrane Central) for randomized controlled trials and clinical trials published from 2010 to 18 January 2021, 562 studies were found. 8 studies were included in this review, with a fair to good quality according to the PEDro scale.
   Results: From a random-effects model meta-analysis, the pooled standardized MMSE mean difference between the intervention and control groups showed a significant small-to-medium effect in global cognition in MMSE score (0.249; 95% CI = [0.067, 0.431]), which seemed to be greater for combined physical and cognitive interventions. However, the meta-analyses did not show any effects regarding specific cognitive functions.
   Conclusion: Our analyses support that MNPI could improve the global cognition in older adults with MCI. However, more studies are needed to analyze the potential benefits of MNPI on older adults with MCI.
C1 [Gomez-Soria, Isabel; Peralta-Marrupe, Patricia; Calatayud, Estela] Univ Zaragoza, Fac Hlth Sci, Dept Physiatry & Nursing, Zaragoza, Spain.
   [Marin-Puyalto, Jorge] Univ Zaragoza, Fac Hlth & Sport Sci, Dept Physiatry & Nursing, C Pedro Cerbuna 12, E-50009 Zaragoza, Spain.
   [Marin-Puyalto, Jorge] Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain.
   [Marin-Puyalto, Jorge] Inst Agroalimentario Aragon IA2, Zaragoza, Spain.
   [Latorre, Eva] Univ Zaragoza, Fac Sci, Dept Biochem & Mol & Cell Biol, Zaragoza, Spain.
   [Gomez-Soria, Isabel; Latorre, Eva; Calatayud, Estela] Inst Hlth Res Aragon IIS Aragon, Zaragoza, Spain.
C3 University of Zaragoza; University of Zaragoza; University of Zaragoza;
   University of Zaragoza
RP Marin-Puyalto, J (corresponding author), Univ Zaragoza, Fac Hlth & Sport Sci, Dept Physiatry & Nursing, C Pedro Cerbuna 12, E-50009 Zaragoza, Spain.
EM isabelgs@unizar.es; jmarinp@unizar.es; peraltamarrupe@hotmail.com;
   evalatorre@unizar.es; estelacs@unizar.es
RI Gómez-Soria, Isabel/ITU-7980-2023; SANZ, ESTELA CALATAYUD/AFC-4477-2022;
   Gómez-Soria, Isabel/HOH-7752-2023; Marin-Puyalto, Jorge/G-5259-2015
OI Gómez-Soria, Isabel/0000-0002-0061-3312; Gómez-Soria,
   Isabel/0000-0002-0061-3312; Marin-Puyalto, Jorge/0000-0002-1042-542X
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NR 59
TC 3
Z9 3
U1 7
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD NOV-DEC
PY 2022
VL 103
AR 104751
DI 10.1016/j.archger.2022.104751
EA JUL 2022
PG 14
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 4L8NE
UT WOS:000852885300001
PM 35839574
DA 2023-08-17
ER

PT J
AU McGrattan, AM
   McEvoy, CT
   McGuinness, B
   McKinley, MC
   Woodside, JV
AF McGrattan, Andrea M.
   McEvoy, Claire T.
   McGuinness, Bernadette
   McKinley, Michelle C.
   Woodside, Jayne V.
TI Effect of dietary interventions in mild cognitive impairment: a
   systematic review
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Diet; Lifestyle; Interventions; Mild cognitive impairment; Systematic
   reviews
ID SUPPLEMENTATION IMPROVES MEMORY; FISH-OIL SUPPLEMENTATION;
   ALZHEIMERS-DISEASE; MEDITERRANEAN DIET; OLDER-ADULTS; CALORIC
   RESTRICTION; WORKING GROUP; DOUBLE-BLIND; B VITAMINS; DECLINE
AB Diet has been investigated in relation to its ability to promote cognitive function. However, evidence is currently limited and has rarely been systematically reviewed, particularly in a mild cognitive impairment (MCI) population. This review examined the effect of diet on cognitive outcomes in MCI patients. A total of five databases were searched to find randomised controlled trial (RCT) studies, with diet as the main focus, in MCI participants. The primary outcome was incident dementia and/or Alzheimer's disease (AD) and secondary outcomes included cognitive function across different domains using validated neuropsychological tests. Sixteen studies met the inclusion criteria. There was a high degree of heterogeneity relating to the nature of the dietary intervention and cognitive outcomes measured, thus making study comparisons difficult. Supplementation with vitamin E (one study, n 516), ginkgo biloba (one study, n 482) or Fortasyn Connect (one study, n 311) had no significant effect on progression from MCI to dementia and/or AD. For cognitive function, the findings showed some improvements in performance, particularly in memory, with the most consistent results shown by B vitamins, including folic acid (one study, n 266), folic acid alone (one study, n 180), DHA and EPA (two studies, n 36 and n 86), DHA (one study, n 240) and flavonol supplementation (one study, n 90). The findings indicate that dietary factors may have a potential benefit for cognitive function in MCI patients. Further well-designed trials are needed, with standardised and robust measures of cognition to investigate the influence of diet on cognitive status.
C1 [McGrattan, Andrea M.; McEvoy, Claire T.; McGuinness, Bernadette; McKinley, Michelle C.; Woodside, Jayne V.] Queens Univ Belfast, Ctr Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland.
   [McEvoy, Claire T.] Univ Calif San Francisco, Global Brain Hlth Inst, Vet Affairs Med Ctr 116 H, 4150 Clement St, San Francisco, CA 94121 USA.
C3 Queens University Belfast; University of California System; University
   of California San Francisco
RP McGrattan, AM (corresponding author), Queens Univ Belfast, Ctr Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland.
EM amcgrattan02@qub.ac.uk
RI McGrattan, Andrea/ABB-4286-2020; McGuinness, Bernadette/AAH-2755-2021;
   McGrattan, Andrea/AAW-8235-2020
OI McGuinness, Bernadette/0000-0002-7028-5633; McGrattan,
   Andrea/0000-0003-1521-213X; McEvoy, Claire/0000-0001-8512-3293;
   Woodside, Jayne/0000-0002-5691-4659; McKinley,
   Michelle/0000-0003-3386-1504
FU Wellcome Trust [202097] Funding Source: Medline
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NR 85
TC 43
Z9 44
U1 2
U2 45
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 28
PY 2018
VL 120
IS 12
BP 1388
EP 1405
DI 10.1017/S0007114518002945
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HI4QZ
UT WOS:000456436800008
PM 30409231
OA Green Accepted, Bronze, Green Published
DA 2023-08-17
ER

PT J
AU Lu, YYF
   Ellis, J
   Yang, ZY
   Weaver, MT
   Bakas, T
   Austrom, MG
   Haase, JE
AF Lu, Yvonne Yueh-Feng
   Ellis, Jennifer
   Yang, Ziyi
   Weaver, Michael T.
   Bakas, Tamilyn
   Austrom, Mary Guerriero
   Haase, Joan E.
TI Satisfaction With a Family-Focused Intervention for Mild Cognitive
   Impairment Dyads
SO JOURNAL OF NURSING SCHOLARSHIP
LA English
DT Article
DE Cognitive impairment; satisfaction; tailored intervention; dyad;
   meaningful activities; family caregivers
ID LATE-LIFE DEPRESSION; MEANINGFUL ACTIVITY; ALZHEIMERS-DISEASE; CONTENT
   VALIDITY; CAREGIVER; DEMENTIA; AWARENESS; SPOUSE
AB PurposeThis article describes satisfaction that persons with mild cognitive impairment (PwMCI) and their caregivers had with the Daily Enhancement of Meaningful Activity (DEMA) intervention.
   MethodsThis randomized controlled pilot study compared satisfaction (usefulness, ease of use, and acceptability) with DEMA (n = 17 dyads) to an information support (IS) control group (n = 19 dyads). Six biweekly sessions (two in person and four by telephone) were delivered by trained nurses. Data analysis included descriptive statistics, independent-sample t tests, and content analysis.
   FindingsPwMCI receiving DEMA rated their satisfaction significantly higher (p = .033) than did the control group; there was no difference in satisfaction between caregivers across groups. Qualitative interview data supported the usefulness, ease of use, and acceptability of DEMA for both PwMCI and caregivers.
   ConclusionsResults documented PwMCI's satisfaction with DEMA as implemented by nurses to support PwMCI-caregiver dyads' engagement in meaningful activity. DEMA may need revision to increase satisfaction for caregivers.
   Clinical RelevanceThe DEMA intervention was evaluated as useful, easy to use, and acceptable to PwMCI and their caregivers based on positive mean ratings. The study findings provide preliminary support of DEMA as a means to improve quality of life by helping to support patient and caregiver engagement in meaningful activities and problem solving.
C1 [Lu, Yvonne Yueh-Feng] Indiana Univ, Sch Nursing, Dept Sci Nursing Care, 1111 Middle Dr,NU W407, Indianapolis, IN 46202 USA.
   [Ellis, Jennifer] Indiana Univ, Sch Hlth & Rehabil, Indianapolis, IN 46204 USA.
   [Yang, Ziyi] Indiana Univ Sch Med, Dept Biostat, Indianapolis, IN 46202 USA.
   [Weaver, Michael T.] Univ Florida, Coll Nursing, Res & Scholarship, Gainesville, FL 32611 USA.
   [Bakas, Tamilyn] Indiana Univ, Sch Nursing, Indianapolis, IN 46204 USA.
   [Bakas, Tamilyn] Univ Cincinnati, Coll Nursing, Cincinnati, OH USA.
   [Austrom, Mary Guerriero] Indiana Univ Sch Med, Dept Psychiat, Alzheimers Dis Educ, Indianapolis, IN 46202 USA.
   [Austrom, Mary Guerriero] Indiana Univ Sch Med, Divers Affairs, Indianapolis, IN 46202 USA.
   [Austrom, Mary Guerriero] IADC, Outreach Recruitment & Educ Core, Indianapolis, IN USA.
   [Haase, Joan E.] Indiana Univ, Sch Nursing, Dept Sci Nursing Care, Pediat Oncol Nursing, Indianapolis, IN 46204 USA.
C3 Indiana University System; Indiana University-Purdue University
   Indianapolis; Indiana University System; Indiana University-Purdue
   University Indianapolis; Indiana University System; Indiana University
   Bloomington; State University System of Florida; University of Florida;
   Indiana University System; Indiana University-Purdue University
   Indianapolis; University System of Ohio; University of Cincinnati;
   Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington; Indiana University
   System; Indiana University-Purdue University Indianapolis
RP Lu, YYF (corresponding author), Indiana Univ, Sch Nursing, Dept Sci Nursing Care, 1111 Middle Dr,NU W407, Indianapolis, IN 46202 USA.
EM yuelu@iu.edu
RI Bakas, Tamilyn/ABC-5664-2020
OI Weaver, Michael/0000-0002-6630-4758
FU NIH, NINR [1R21 NR013755-01]; NIH [O30AG10133]
FX This research was supported by the NIH, NINR 1R21 NR013755-01 (PI: Dr.
   Lu). M.G. Austrom was also supported in part by NIH O30AG10133.
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NR 31
TC 13
Z9 13
U1 1
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6546
EI 1547-5069
J9 J NURS SCHOLARSHIP
JI J. Nurs. Scholarsh.
PD JUL
PY 2016
VL 48
IS 4
BP 334
EP 344
DI 10.1111/jnu.12214
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA DR5CI
UT WOS:000379920200002
PM 27121662
OA Green Accepted, Green Submitted
DA 2023-08-17
ER

PT J
AU O'Sullivan, M
   Coen, R
   O'Hora, D
   Shiel, A
AF O'Sullivan, Maria
   Coen, Robert
   O'Hora, Denis
   Shiel, Agnes
TI Cognitive rehabilitation for mild cognitive impairment: developing and
   piloting an intervention
SO AGING NEUROPSYCHOLOGY AND COGNITION
LA English
DT Article
DE cognitive rehabilitation; mild cognitive impairment; goal attainment
   scaling; family dyads
ID ALZHEIMERS-DISEASE; MEMORY; PLASTICITY; PEOPLE
AB This was an exploratory study, with the purpose of developing and piloting an intervention for people with mild cognitive impairment (MCI) and their family members using cognitive rehabilitation. A case series design was used with pre- and post-intervention and 3-month follow-up outcome measures. Five participants (two males, three females; mean age 75years) with a diagnosis of MCI attended the memory clinic with a family member. Intervention consisted of six to eight individual sessions of cognitive rehabilitation consisting of personalized interventions to address individually relevant goals delivered weekly. The main rehabilitation strategies utilized were external aids, personal diary, face-name association, relaxation, and encouraging participants to develop habits and routines. The primary outcome measure was goal attainment as assessed by Goal Attainment Scaling. Secondary outcome measures included measures of memory, anxiety, depression, and activities of daily living. Qualitative data were collected post-intervention by interview. Post-intervention 84% of the goals were attained, with 68% maintained at a 3-month follow-up. Mean anxiety and depression scores decreased during the intervention. No significant changes were recorded on a test of memory. The findings suggest that the strongest effect was in relation to compensatory strategies for prospective and episodic memory deficits. Feedback from participants during qualitative interviews indicated that they found strategies useful and implemented them in their daily routines. The findings support the use of a dyadic cognitive rehabilitation intervention for people with MCI and memory difficulties.
C1 [O'Sullivan, Maria] St Finbarrs Hosp, Dept Clin Psychol, HSE South, Cork, Ireland.
   [Coen, Robert] St James Hosp, Mercers Inst Res Ageing, Memory Clin, Dublin 8, Ireland.
   [O'Hora, Denis] Natl Univ Ireland Galway, Dept Psychol, Galway, Ireland.
   [Shiel, Agnes] Natl Univ Ireland Galway, Dept Occupat Therapy, Galway, Ireland.
C3 Trinity College Dublin; Ollscoil na Gaillimhe-University of Galway;
   Ollscoil na Gaillimhe-University of Galway
RP O'Sullivan, M (corresponding author), St Finbarrs Hosp, Dept Clin Psychol, HSE South, Cork, Ireland.
EM maria.osullivan5@hse.ie
RI Shiel, Agnes/AAA-4211-2019; O'hora, Denis/I-4227-2016
OI O'hora, Denis/0000-0003-3776-6782
CR Albert MS, 2011, ALZHEIMERS DEMENT, V7, P270, DOI 10.1016/j.jalz.2011.03.008
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NR 36
TC 14
Z9 14
U1 3
U2 40
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1382-5585
EI 1744-4128
J9 AGING NEUROPSYCHOL C
JI Aging Neuropsychol. Cogn.
PD MAY 4
PY 2015
VL 22
IS 3
BP 280
EP 300
DI 10.1080/13825585.2014.927818
PG 21
WC Psychology, Developmental; Psychology, Experimental
WE Social Science Citation Index (SSCI)
SC Psychology
GA CB2KB
UT WOS:000349454900002
PM 24955493
DA 2023-08-17
ER

PT J
AU Bayer-Carter, JL
   Green, PS
   Montine, TJ
   VanFossen, B
   Baker, LD
   Watson, S
   Bonner, LM
   Callaghan, M
   Leverenz, JB
   Walter, BK
   Tsai, E
   Plymate, SR
   Postupna, N
   Wilkinson, CW
   Zhang, J
   Lampe, J
   Kahn, SE
   Craft, S
AF Bayer-Carter, Jennifer L.
   Green, Pattie S.
   Montine, Thomas J.
   VanFossen, Brian
   Baker, Laura D.
   Watson, Stennis
   Bonner, Laura M.
   Callaghan, Maureen
   Leverenz, James B.
   Walter, Brooke K.
   Tsai, Elaine
   Plymate, Stephen R.
   Postupna, Nadia
   Wilkinson, Charles W.
   Zhang, Jing
   Lampe, Johanna
   Kahn, Steven E.
   Craft, Suzanne
TI Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild
   Cognitive Impairment
SO ARCHIVES OF NEUROLOGY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; ALZHEIMERS-DISEASE; A-BETA; INSULIN-RESISTANCE;
   MOUSE MODEL; MEDITERRANEAN DIET; BRAIN; PLASMA; DEMENTIA; RISK
AB Objective: To compare the effects of a 4-week high-saturated fat/high-glycemic index (HIGH) diet with a low-saturated fat/low-glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers of Alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (aMCI).
   Design: Randomized controlled trial.
   Setting: Veterans Affairs Medical Center clinical research unit.
   Participants: Forty-nine older adults (20 healthy adults with a mean [SD] age of 69.3 [7.4] years and 29 adults with aMCI with a mean [SD] age of 67.6 [6.8] years).
   Intervention: Participants received the HIGH diet (fat, 45% [saturated fat, >25%]; carbohydrates, 35%-40% [glycemic index, >70]; and protein, 15%-20%) or the LOW diet (fat, 25%; [saturated fat, <7%]; carbohydrates, 55%-60% [glycemic index, <55]; and protein, 15%-20%) for 4 weeks. Cognitive tests, an oral glucose tolerance test, and lumbar puncture were conducted at baseline and during the fourth week of the diet.
   Main Outcome Measures: The CSF concentrations of beta-amyloid (A beta 42 and A beta 40), tau protein, insulin, F2-isoprostanes, and apolipoprotein E, plasma lipids and insulin, and measures of cognition.
   Results: For the aMCI group, the LOW diet increased CSF A beta 42 concentrations, contrary to the pathologic pattern of lowered CSF A beta 42 typically observed in Alzheimer disease. The LOW diet had the opposite effect for healthy adults, ie, decreasing CSF A beta 42, whereas the HIGH diet increased CSF A beta 42. The CSF apolipoprotein E concentration was increased by the LOW diet and decreased by the HIGH diet for both groups. For the aMCI group, the CSF insulin concentration increased with the LOW diet, but the HIGH diet lowered the CSF insulin concentration for healthy adults. The HIGH diet increased and the LOW diet decreased plasma lipids, insulin, and CSF F2-isoprostane concentrations. Delayed visual memory improved for both groups after completion of 4 weeks of the LOW diet.
   Conclusion: Our results suggest that diet may be a powerful environmental factor that modulates Alzheimer disease risk through its effects on central nervous system concentrations of A beta 42, lipoproteins, oxidative stress, and insulin.
C1 [Walter, Brooke K.] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Dept Neurol, Seattle, WA 98108 USA.
   [Leverenz, James B.] Vet Affairs Puget Sound Hlth Care Syst, Parkinsons Dis Res Educ & Clin Ctr, Seattle, WA 98108 USA.
   [Kahn, Steven E.] Vet Affairs Puget Sound Hlth Care Syst, Dept Med, Seattle, WA 98108 USA.
   [Bayer-Carter, Jennifer L.; VanFossen, Brian; Baker, Laura D.; Watson, Stennis; Bonner, Laura M.; Wilkinson, Charles W.; Craft, Suzanne] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Green, Pattie S.; Tsai, Elaine; Plymate, Stephen R.; Kahn, Steven E.] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA.
   [Montine, Thomas J.; Postupna, Nadia; Zhang, Jing] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA.
   [Leverenz, James B.; Walter, Brooke K.] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98195 USA.
   [Lampe, Johanna] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
C3 Geriatric Research Education & Clinical Center; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Vet Affairs
   Puget Sound Health Care System; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Vet Affairs Puget Sound Health
   Care System; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Vet Affairs Puget Sound Health Care System;
   University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle; Fred Hutchinson Cancer Center
RP Craft, S (corresponding author), Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr S 182, 1660 S Columbian Way, Seattle, WA 98108 USA.
EM scraft@u.washington.edu
RI Wilkinson, Charles W/N-5969-2017
OI Wilkinson, Charles W/0000-0002-5390-0294; Kahn,
   Steven/0000-0001-7307-9002; Leverenz, James/0000-0002-0896-0749
FU National Institute on Aging [R37 AG-10880, P50 AG-05136, 5T32
   AG-000258]; Nancy and Buster Alvord Endowment; Veterans Affairs Puget
   Sound Health Care System, Seattle, Washington
FX This research was supported by grant R37 AG-10880 from the National
   Institute on Aging to Dr Craft, grant P50 AG-05136 to Dr Montine, and
   grant 5T32 AG-000258 to Dr Postupna and supported by funding from the
   Nancy and Buster Alvord Endowment to Dr Montine. This article results
   from work supported by resources from the Veterans Affairs Puget Sound
   Health Care System, Seattle, Washington.
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NR 59
TC 107
Z9 116
U1 0
U2 29
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0003-9942
J9 ARCH NEUROL-CHICAGO
JI Arch. Neurol.
PD JUN
PY 2011
VL 68
IS 6
BP 743
EP 752
DI 10.1001/archneurol.2011.125
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 776ON
UT WOS:000291546100008
PM 21670398
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Hu, MY
   Hu, HY
   Shao, ZF
   Gao, YY
   Zeng, XM
   Shu, XH
   Huang, JD
   Shen, SS
   Wu, IXY
   Xiao, LD
   Feng, H
AF Hu, Mingyue
   Hu, Hengyu
   Shao, Zhanfang
   Gao, Yinyan
   Zeng, Xianmei
   Shu, Xinhui
   Huang, Jundan
   Shen, Shanshan
   Wu, Irene X. Y.
   Xiao, Lily Dongxia
   Feng, Hui
TI Effectiveness and acceptability of non-pharmacological interventions in
   people with mild cognitive impairment: Overview of systematic reviews
   and network meta-analysis
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Overview of systematic review; Network meta-analysis;
   Non-pharmacological intervention
ID PHYSICAL-EXERCISE; OLDER-ADULTS; DEMENTIA; HOMOCYSTEINE; MEMORY; MODEL
AB Background: To explore effectiveness and acceptability of non-pharmacological interventions in mild cognitive impairment (MCI).
   Methods: Overview of systematic reviews and network meta-analysis were conducted. Systematic reviews (SRs) were searched via seven databases from June 2015 to June 2020. Randomized controlled trials (RCTs) were retrieved. The Methodological quality was assessed by AMSTAR 2 and RoB 2. Outcomes were effectiveness and acceptability measured by standardized mean differences (SMDs) and odd ratios (ORs) with 95% confidence interval (CI). Pairwise meta-analysis was first conducted, followed by network meta-analysis.
   Results: A total of 22 SRs and 42 RCTs with 4401 participants were included. The methodological quality of included SRs and RCTs were moderate. There were four interventions, with three types of physical activity (aerobic, muscle-strengthening, and mind-body), three types of cognitive (rehearsal-based, compensatory, and mixed), multicomponent (physical and cognitive component), and nutrition intervention. No significant inconsistency was identified. Regarding intervention effectiveness, muscle-strengthening (SMDs 0.87, 95% CI 0.31-1.43; rank 1), mind-body (0.76, 0.38-1.14; rank 2) and aerobic (0.34, 0.13-0.50; rank 3) were significantly better than the control group and there was no significant difference among these types of intervention . Cognitive intervention of rehearsal-based (1.33, 0.30-2.35; rank 1) and mixed (0.55, 0.00-1.11; rank 2) were significantly better than the control group and there was no significant difference among these types of intervention. Multicomponent intervention (0.32, 0.02-0.62) were significantly better than the control group but not better than the single component group. Regarding acceptability, there was no significant difference among types of intervention.
   Conclusion: Physical activity, cognitive, and multicomponent intervention could be provided regardless of their types and acceptability due to their effectiveness on improved cognitive function for people with MCI.
C1 [Hu, Mingyue; Hu, Hengyu; Gao, Yinyan; Zeng, Xianmei; Huang, Jundan; Feng, Hui] Cent South Univ, Xiangya Nursing Sch, 172 Tongzipo Rd, Changsha, Peoples R China.
   [Shao, Zhanfang; Wu, Irene X. Y.] Cent South Univ, Xiangya Sch Publ Hlth, 238 Shang Ma Yuan Ling Alley, Changsha, Hunan, Peoples R China.
   [Shu, Xinhui] Kaifeng Cent Hosp, Kaifeng, Peoples R China.
   [Shen, Shanshan] Zhejiang Hosp, Hangzhou, Zhejiang, Peoples R China.
   [Xiao, Lily Dongxia] Flinders Univ S Australia, Coll Nursing & Hlth Sci, Adelaide, SA, Australia.
   [Feng, Hui] Cent South Univ, Oceanwide Hlth Management Inst, Changsha, Peoples R China.
   [Feng, Hui] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
C3 Central South University; Central South University; Flinders University
   South Australia; Central South University; Central South University
RP Feng, H (corresponding author), Cent South Univ, Xiangya Nursing Sch, 172 Tongzipo Rd, Changsha, Peoples R China.; Wu, IXY (corresponding author), Cent South Univ, Xiangya Sch Publ Hlth, 238 Shang Ma Yuan Ling Alley, Changsha, Hunan, Peoples R China.; Xiao, LD (corresponding author), Flinders Univ S Australia, Coll Nursing & Hlth Sci, Adelaide, SA, Australia.
EM irenexywu@csu.edu.cn; lily.xiao@flinders.edu.au; feng.hui@csu.edu.cn
RI Xiao, Lily Dongxia/N-8144-2014
OI Xiao, Lily Dongxia/0000-0002-4631-2443
FU Central South University Innovation-driven project [2021zzts0337];
   Chinese Scholarship Council [202006360116]; Con-struction of Innovative
   Provinces in Hunan [2020SK2055]; Special Funding for the Construction of
   Innovative Provinces in Hunan; National Key RAMP;D Program of China
   [2020YFC2008603, 2020YFC2008602]; China Oceanwide Holdings Group Project
   Fund [143010100]
FX This work was supported by the Central South University
   Innovation-driven project (Grant No. 2021zzts0337) , the Chinese
   Scholarship Council (Grant No. 202006360116) , the Special Funding for
   the Construction of Innovative Provinces in Hunan (Grant No. 2020SK2055)
   , the National Key R&D Program of China (Grant No. 2020YFC2008603,
   2020YFC2008602) , and the China Oceanwide Holdings Group Project Fund
   (Grant No. 143010100) .
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NR 47
TC 0
Z9 0
U1 5
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 15
PY 2022
VL 311
BP 383
EP 390
DI 10.1016/j.jad.2022.05.043
EA MAY 2022
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 2E6TF
UT WOS:000812359100033
PM 35597472
DA 2023-08-17
ER

PT J
AU Nagaoka, M
   Hashimoto, Z
   Takeuchi, H
   Sado, M
AF Nagaoka, Maki
   Hashimoto, Zenta
   Takeuchi, Hiroyoshi
   Sado, Mitsuhiro
TI Effectiveness of mindfulness-based interventions for people with
   dementia and mild cognitive impairment: A meta-analysis and implications
   for future research
SO PLOS ONE
LA English
DT Article
ID STRESS REDUCTION; OLDER-ADULTS; THERAPY; DEPRESSION; ANXIETY; SCALE;
   VALIDATION; PROGRAM; BIAS
AB Objective To assess the effectiveness of mindfulness-based interventions on people with dementia and mild cognitive impairment. Methods We searched several electronic databases, namely Cochrane Library, EMBASE, and MEDLINE with no limitations for language or document type (last search: 1 February 2020). Randomized controlled trials of mindfulness-based interventions for people with dementia and mild cognitive impairment compared to active-control interventions, waiting lists, or treatment as usual were included. Predefined outcomes were anxiety symptoms, depressive symptoms, cognitive function, quality of life, mindfulness, ADL and attrition. We used the random effects model (DerSimonian-Laird method) for meta-analysis, reporting effect sizes as Standardized Mean Difference. Heterogeneity was assessed with the I-2 statistics. Results Eight randomized controlled trials, involving 276 patients, met the eligibility criteria and were included in the meta-analysis. We found no significant effects for mindfulness-based interventions in either the short-term or the medium- to long-term on any outcomes, when compared with control conditions. The number of included studies and sample sizes were too small. Additionally, the quality of evidence was low for each randomized controlled trial included in the analysis. This is primarily due to lack of intent-to-treat analysis, high risk of bias, and imprecise study results. The limited statistical power and weak body of evidence prevented us from reaching firm conclusions. Conclusions We found no significant effects of mindfulness-based interventions on any of the outcomes when compared with control conditions. The evidence concerning the efficacy of mindfulness-based interventions in this population is scarce in terms of both quality and quantity. More well-designed, rigorous, and large-scale randomized controlled trials are needed.
C1 [Nagaoka, Maki; Hashimoto, Zenta; Takeuchi, Hiroyoshi; Sado, Mitsuhiro] Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan.
   [Hashimoto, Zenta] Yokohama Municipal Citizens Hosp, Dept Neuropsychiat, Yokohama, Kanagawa, Japan.
   [Sado, Mitsuhiro] Keio Univ, Ctr Stress Res, Tokyo, Japan.
C3 Keio University; Keio University
RP Sado, M (corresponding author), Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan.; Sado, M (corresponding author), Keio Univ, Ctr Stress Res, Tokyo, Japan.
EM mitsusado@keio.jp
OI Nagaoka, Maki/0000-0001-9555-0467; Sado, Mitsuhiro/0000-0002-2626-8123
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NR 46
TC 5
Z9 5
U1 1
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2021
VL 16
IS 8
AR e0255128
DI 10.1371/journal.pone.0255128
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA TT3IC
UT WOS:000680243400023
PM 34339428
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Jeong, MK
   Park, KW
   Ryu, JK
   Kim, GM
   Jung, HH
   Park, H
AF Jeong, Min-Ki
   Park, Kyung-Won
   Ryu, Je-Kwang
   Kim, Gwon-Min
   Jung, Hyun-Hun
   Park, Hyuntae
TI Multi-Component Intervention Program on Habitual Physical Activity
   Parameters and Cognitive Function in Patients with Mild Cognitive
   Impairment: A Randomized Controlled Trial
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE multi-component intervention; mild cognitive impairment; dementia;
   habitual physical activity parameters; cognitive function
ID OLDER-ADULTS; DEPRESSIVE SYMPTOMS; ALZHEIMERS-DISEASE; ELDERLY JAPANESE;
   AEROBIC EXERCISE; BRAIN VOLUME; RISK-FACTORS; WALKING; DEMENTIA; HEALTH
AB Age-related dementia refers to a state in which someone experiences multiple cognitive function impairment due to degenerative brain disease, and which causes difficulties in their daily life or social life. Dementia is the most common and serious obstacle in later life. Early intervention in the case of patients who are in the mild cognitive impairment (MCI) stage among the high-risk group can maintain and improve their cognitive function. The purpose of the current trial is aimed at investigating the association between a multi-component (exercise with cognitive) intervention program and habitual physical activity parameters on cognitive functions in MCI patients. Neuropsychological cognitive and depression assessments were performed by neuropsychologists according to normalized methods, including the Korean mini-mental State examination (K-MMSE) and modified Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog) and cognitive assessment tool (attention, processing speed), and the Korean version of the geriatric depression scale (SGDS-K), both at baseline and at a 12 weeks follow-up. The 12-week multi-component intervention improved cognitive function and habitual physical activity parameters in patients with MCI relative to controls. A multi-component intervention program for patients with MCI is considered to be an effective method of dementia prevention by improving global (ADAS-Cog) and frontal (trail-making test, digit symbol substitution test) cognition and habitual physical activity parameters such as moderate to vigorous physical activity and step count. In addition, it is important to encourage habitual physical activities to ensure that exercise intervention strategies are carried out at the duration and intensity required for improving physical and cognitive wellbeing and obtaining health benefits.
C1 [Jeong, Min-Ki; Jung, Hyun-Hun] Dong A Univ, Coll Arts & Sports, Busan 49315, South Korea.
   [Park, Kyung-Won] Busan Metropolitan Dementia Ctr, Busan 49201, South Korea.
   [Park, Kyung-Won] Dong A Univ, Dept Neurol, Coll Med, Busan 49201, South Korea.
   [Ryu, Je-Kwang; Park, Hyuntae] Dong A Univ, Dept Hlth Sci, Grad Sch, Busan 49201, South Korea.
   [Kim, Gwon-Min] Pusan Natl Univ Hosp, Biomed Res Inst, Hlth Convergence Med Lab, Busan 49241, South Korea.
   [Park, Hyuntae] Natl Ctr Geriatr & Gerontol, Ctr Gerontol & Social Sci, Obu 4748511, Japan.
C3 Dong A University; Dong A University; Dong A University; Pusan National
   University; Pusan National University Hospital; National Center for
   Geriatrics & Gerontology
RP Park, H (corresponding author), Dong A Univ, Dept Hlth Sci, Grad Sch, Busan 49201, South Korea.; Park, H (corresponding author), Natl Ctr Geriatr & Gerontol, Ctr Gerontol & Social Sci, Obu 4748511, Japan.
EM prof.mkjeong@gmail.com; neuropark@dau.ac.kr; ljk080617@gmail.com;
   rlarnjsals47@gmail.com; jhh320@gmail.com; htpark@dau.ac.kr
RI Hyun-Hun, JUNG/GLR-2887-2022; Park, Hyuntae/AAE-4672-2019
OI Park, Hyuntae/0000-0002-1976-0005; Kim, Gwon Min/0000-0001-7901-3506;
   Park, Kyung Won/0000-0002-6788-5267; JUNG, Hyun-Hun/0000-0001-7211-083X;
   Jeong, Min-Ki/0000-0003-0640-3866
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NR 52
TC 8
Z9 8
U1 3
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUN
PY 2021
VL 18
IS 12
AR 6240
DI 10.3390/ijerph18126240
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA TA6SA
UT WOS:000667377100001
PM 34207701
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Huckans, M
   Hutson, L
   Twamley, E
   Jak, A
   Kaye, J
   Storzbach, D
AF Huckans, Marilyn
   Hutson, Lee
   Twamley, Elizabeth
   Jak, Amy
   Kaye, Jeffrey
   Storzbach, Daniel
TI Efficacy of Cognitive Rehabilitation Therapies for Mild Cognitive
   Impairment (MCI) in Older Adults: Working Toward a Theoretical Model and
   Evidence-Based Interventions
SO NEUROPSYCHOLOGY REVIEW
LA English
DT Review
DE Mild cognitive impairment; Cognitive rehabilitation therapy; Cognitive
   training; Systematic review; Neuropsychological; Dementia
ID QUALITY-OF-LIFE; RISK-FACTORS; ALZHEIMERS-DISEASE; PREDICT CONVERSION;
   PHARMACOLOGICAL-TREATMENT; DEPRESSIVE SYMPTOMS; MEDITERRANEAN DIET;
   PHYSICAL-ACTIVITY; CLINICAL-TRIALS; DEMENTIA
AB To evaluate the efficacy of cognitive rehabilitation therapies (CRTs) for mild cognitive impairment (MCI). Our review revealed a need for evidence-based treatments for MCI and a lack of a theoretical rehabilitation model to guide the development and evaluation of these interventions. We have thus proposed a theoretical rehabilitation model of MCI that yields key intervention targets-cognitive compromise, functional compromise, neuropsychiatric symptoms, and modifiable risk and protective factors known to be associated with MCI and dementia. Our model additionally defines specific cognitive rehabilitation approaches that may directly or indirectly target key outcomes-restorative cognitive training, compensatory cognitive training, lifestyle interventions, and psychotherapeutic techniques. Fourteen randomized controlled trials met inclusion criteria and were reviewed. Studies markedly varied in terms of intervention approaches and selected outcome measures and were frequently hampered by design limitations. The bulk of the evidence suggested that CRTs can change targeted behaviors in individuals with MCI and that CRTs are associated with improvements in objective cognitive performance, but the pattern of effects on specific cognitive domains was inconsistent across studies. Other important outcomes (i.e., daily functioning, quality of life, neuropsychiatric symptom severity) were infrequently assessed across studies. Few studies evaluated long-term outcomes or the impact of CRTs on conversion rates from MCI to dementia or normal cognition. Overall, results from trials are promising but inconclusive. Additional well-designed and adequately powered trials are warranted and required before CRTs for MCI can be considered evidence-based.
C1 [Huckans, Marilyn; Storzbach, Daniel] Portland VA Med Ctr, Res & Dev Serv, Portland, OR 97239 USA.
   [Huckans, Marilyn; Hutson, Lee; Storzbach, Daniel] Portland VA Med Ctr, Behav Hlth & Clin Neurosci Div, Portland, OR 97239 USA.
   [Huckans, Marilyn; Storzbach, Daniel] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA.
   [Twamley, Elizabeth] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92093 USA.
   [Twamley, Elizabeth] Univ Calif San Diego, Stein Inst Res Aging, San Diego, CA 92093 USA.
   [Twamley, Elizabeth] VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA 92161 USA.
   [Jak, Amy] VA San Diego Healthcare Syst, Dept Psychol Serv, San Diego, CA 92161 USA.
   [Kaye, Jeffrey] Portland VA Med Ctr, Dept Neurol, Portland, OR 97239 USA.
   [Kaye, Jeffrey] Oregon Hlth & Sci Univ, Layton Aging & Alzheimers Dis Ctr, Portland, OR 97239 USA.
   [Kaye, Jeffrey] Oregon Hlth & Sci Univ, Oregon Ctr Aging & Technol ORATECH, Portland, OR 97239 USA.
   [Huckans, Marilyn] Portland VA Med Ctr MHN, Portland, OR 97239 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Portland VA Medical Center; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Portland VA Medical Center; Oregon Health &
   Science University; University of California System; University of
   California San Diego; University of California System; University of
   California San Diego; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA San Diego Healthcare System; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA San Diego
   Healthcare System; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Portland VA Medical Center; Oregon Health &
   Science University; Oregon Health & Science University
RP Huckans, M (corresponding author), Portland VA Med Ctr MHN, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA.
EM marilyn.huckans@va.gov
OI Kaye, Jeffrey/0000-0002-9971-3478
FU VA Merit Review awards; National Institute on Drug Abuse
   [2P50DA018165-06A1]; National Institute on Aging [P30AG08017,
   P30AG024978]
FX This material is the result of work supported with resources and the use
   of facilities at the Portland Veterans Affairs Medical Center, Portland,
   Oregon and Oregon Health & Science University, Portland Oregon. This
   work is in part supported by VA Merit Review awards to DS and JK, a
   grant from the National Institute on Drug Abuse to MH
   (2P50DA018165-06A1), and grants from the National Institute on Aging to
   JK (P30AG08017; P30AG024978). All authors read and approved the final
   contents of the manuscript.
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NR 84
TC 111
Z9 116
U1 8
U2 95
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1040-7308
EI 1573-6660
J9 NEUROPSYCHOL REV
JI Neuropsychol. Rev.
PD MAR
PY 2013
VL 23
IS 1
SI SI
BP 63
EP 80
DI 10.1007/s11065-013-9230-9
PG 18
WC Psychology, Clinical; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA 107MR
UT WOS:000316222200005
PM 23471631
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Tadokoro, K
   Morihara, R
   Ohta, Y
   Hishikawa, N
   Kawano, S
   Sasaki, R
   Matsumoto, N
   Nomura, E
   Nakano, Y
   Takahashi, Y
   Takemoto, M
   Yamashita, T
   Ueno, S
   Wakutani, Y
   Takao, Y
   Morimoto, N
   Kutoku, Y
   Sunada, Y
   Taomoto, K
   Manabe, Y
   Deguchi, K
   Higashi, Y
   Inufusa, H
   You, F
   Yoshikawa, T
   von Greiffenclau, MM
   Abe, K
AF Tadokoro, Koh
   Morihara, Ryuta
   Ohta, Yasuyuki
   Hishikawa, Nozomi
   Kawano, Satoko
   Sasaki, Ryo
   Matsumoto, Namiko
   Nomura, Emi
   Nakano, Yumiko
   Takahashi, Yoshiaki
   Takemoto, Mami
   Yamashita, Toru
   Ueno, Setsuko
   Wakutani, Yosuke
   Takao, Yoshiki
   Morimoto, Nobutoshi
   Kutoku, Yumiko
   Sunada, Yoshihide
   Taomoto, Katsushi
   Manabe, Yasuhiro
   Deguchi, Kentaro
   Higashi, Yasuto
   Inufusa, Haruhiko
   You, Fukka
   Yoshikawa, Toshikazu
   von Greiffenclau, Markus Matuschka
   Abe, Koji
TI Clinical Benefits of Antioxidative Supplement Twendee X for Mild
   Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and
   Placebo-Controlled Prospective Interventional Study
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Dementia; dietary supplement; mild cognitive impairment; oxidative
   stress; randomized controlled trial
ID MENTAL-STATE-EXAMINATION; OXIDATIVE STRESS; VITAMIN-E;
   ALZHEIMERS-DISEASE; ROSMARINIC ACID; DYSFUNCTION; DEMENTIA; CURCUMIN;
   DECLINE
AB Oxidative stress is part of the entire pathological process that underlies the development of Alzheimer's disease (AD), including the mild cognitive impairment (MCI) stage. Twendee X (TwX) is a supplement containing a strong antioxidative mix of eight antioxidants, which has been shown to have a clinical and therapeutic benefit in AD model mice. Here, we conducted a multicenter, randomized, double-blind, and placebo-controlled prospective interventional study to evaluate the efficacy of TwX in mitigating MCI. The primary outcomes were differences in Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-revised (HDS-R) scores between baseline and six months for placebo and TwX groups. Seventy-eight subjects with MCI were randomized into placebo (n= 37) and TwX (n= 41) groups. MMSE scores at six months differed significantly between the TwX and placebo groups (p = 0.018), and HDS-R scores for the TwX group exhibited a significant improvement at six months relative to baseline (p = 0.025). The TwX group did not show any change in affective or activities of daily living scores at six months. The present study indicates that strong antioxidative supplement TwX is clinical beneficial for cognitive function in subjects with MCI.
C1 [Tadokoro, Koh; Morihara, Ryuta; Ohta, Yasuyuki; Hishikawa, Nozomi; Kawano, Satoko; Sasaki, Ryo; Matsumoto, Namiko; Nomura, Emi; Nakano, Yumiko; Takahashi, Yoshiaki; Takemoto, Mami; Yamashita, Toru; Abe, Koji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama, Japan.
   [Ueno, Setsuko; Wakutani, Yosuke; Takao, Yoshiki] Kurashiki Heisei Hosp, Dept Neurol, Kurashiki, Okayama, Japan.
   [Morimoto, Nobutoshi] Kagawa Prefectural Cent Hosp, Dept Neurol, Takamatsu, Kagawa, Japan.
   [Kutoku, Yumiko; Sunada, Yoshihide] Kawasaki Med Sch, Dept Neurol, Kurashiki, Okayama, Japan.
   [Taomoto, Katsushi] Ohnishi Neurol Ctr, Dept Neurosurg, Akashi, Hyogo, Japan.
   [Manabe, Yasuhiro] Natl Hosp Org Okayama Med Ctr, Dept Neurol, Okayama, Japan.
   [Deguchi, Kentaro] Okayama City Hosp, Dept Neurol, Okayama, Japan.
   [Higashi, Yasuto] Himeji Cent Hosp, Dept Neurol, Himeji, Hyogo, Japan.
   [Inufusa, Haruhiko] Gifu Univ, Life Sci Res Ctr, Div Antioxidant Res, Gifu, Japan.
   [You, Fukka] Gifu Univ, Life Sci Res Ctr, Div Anaerobe Res, Gifu, Japan.
   [Yoshikawa, Toshikazu] Louis Pasteur Ctr Med Res, Kyoto, Japan.
   [von Greiffenclau, Markus Matuschka] European Med Fdn, TIMA Est, Balzers, Liechtenstein.
C3 Okayama University; Kawasaki Medical School; Gifu University; Gifu
   University
RP Abe, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM p86m6fma@okayama-u.ac.jp
OI Yamashita, Toru/0000-0003-3634-5679
FU Japan Agency for Medical Research and Development [17H0419611,
   15K0931607, 17H0975609, 17K1082709, 7211800049, 7211800130, 7211700121]
FX This work was partly supported by a Grant-in-Aid for Scientific Research
   (B) 17H0419611, (C) 15K0931607, 17H0975609, and 17K1082709, and by
   Grants-in-Aid from the Research Committees (Kaji R, Toba K, and Tsuji S)
   from the Japan Agency for Medical Research and Development 7211800049,
   7211800130, and 7211700121. We want to thank Adam Phillips, PhD, from
   Edanz Group (http://www.edanzediting.com/ac) for editing a draft of this
   manuscript.
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NR 41
TC 9
Z9 9
U1 2
U2 9
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2019
VL 71
IS 3
BP 1063
EP 1069
DI 10.3233/JAD-190644
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA JB8KW
UT WOS:000488819100031
PM 31476161
DA 2023-08-17
ER

PT J
AU Johnson, M
   Lin, F
AF Johnson, Melissa
   Lin, Feng
TI Communication Difficulty and Relevant Interventions in Mild Cognitive
   Impairment Implications for Neuroplasticity
SO TOPICS IN GERIATRIC REHABILITATION
LA English
DT Article
DE compensatory scaffolding; cognitive intervention; mild cognitive
   impairment; communication difficulty; neuroplasticity
ID EARLY ALZHEIMER-DISEASE; OLDER-ADULTS; REHABILITATION PROGRAM; SEMANTIC
   MEMORY; FLUENCY; DEMENTIA; LANGUAGE; STIMULATION; PERFORMANCE; DIAGNOSIS
AB Mild cognitive impairment (MCI) represents a critical point for controlling cognitive decline. Patterns of communication difficulty have been observed in patients with MCI and warrant examination and management. This systematic review examined (1) characteristics of communication difficulty in MCI by focusing on 2 domains, expressive and receptive communication, and (2) cognitive interventions that addressed communication difficulties in individuals with MCI. Of the 28 observational studies reviewed, expressive and receptive communications were generally impaired in individuals with MCI compared with their healthy counterparts. However, only 1 of the 7 interventions effectively improved communication-related outcomes. We summarize the article with a discussion about how neuroplasticity influences communication abilities in individuals with MCI to inform the future development of interventions for communication difficulty.
C1 [Johnson, Melissa; Lin, Feng] Univ Rochester, Med Ctr, Sch Nursing, Rochester, NY 14642 USA.
   [Lin, Feng] Univ Rochester, Med Ctr, Sch Med & Dent, Dept Psychiat, Rochester, NY 14642 USA.
C3 University of Rochester; University of Rochester
RP Lin, F (corresponding author), Univ Rochester, Med Ctr, Sch Nursing, 601 Elmwood Ave,HWH 2w128, Rochester, NY 14642 USA.
EM vankee_lin@urmc.rochester.edu
RI Johnson, Melissa/AAO-7200-2020
OI Lin, Feng Vankee/0000-0003-1945-0362
FU NCATS NIH HHS [KL2 TR000095] Funding Source: Medline
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NR 68
TC 16
Z9 19
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0882-7524
EI 1550-2414
J9 TOP GERIATR REHABIL
JI Top. Geriatr. Rehabil.
PD JAN-MAR
PY 2014
VL 30
IS 1
BP 18
EP 34
DI 10.1097/TGR.0000000000000001
PG 17
WC Gerontology; Rehabilitation
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Rehabilitation
GA AG6YF
UT WOS:000335564300005
PM 25356002
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Sham, R
   Nair, V
   Chertkow, H
   Gauthier, S
   Kurdi, V
   Bherer, L
   Bohbot, V
AF Sham, R.
   Nair, V.
   Chertkow, H.
   Gauthier, S.
   Kurdi, V.
   Bherer, L.
   Bohbot, V.
TI SPATIAL MEMORY INTERVENTION PROGRAM IMPROVES MEMORY IN PATIENTS WITH
   MILD COGNITIVE IMPAIRMENT
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Sham, R.; Nair, V.; Gauthier, S.; Kurdi, V.; Bohbot, V.] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Bherer, L.] Univ Montreal, Dept Psychol, CRIUGM, Montreal, PQ H3C 3J7, Canada.
   [Chertkow, H.] McGill Univ, Jewish Gen Hosp, Dept Neurol & Neurosurg, Montreal, PQ H3T 1E2, Canada.
C3 McGill University; Universite de Montreal; McGill University
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD NOV
PY 2011
VL 51
SU 2
BP 488
EP 488
PG 1
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 936PH
UT WOS:000303602003199
DA 2023-08-17
ER

PT J
AU Yu, JH
   Rawtaer, I
   Feng, L
   Fam, J
   Kumar, AP
   Cheah, IKM
   Honer, WG
   Su, W
   Lee, YK
   Tan, EC
   Kua, EH
   Mahendran, R
AF Yu, Junhong
   Rawtaer, Iris
   Feng, Lei
   Fam, Johnson
   Kumar, Alan Prem
   Cheah, Irwin Kee-Mun
   Honer, William G.
   Su, Wayne
   Lee, Yuan Kun
   Tan, Ene Choo
   Kua, Ee Heok
   Mahendran, Rathi
TI Mindfulness intervention for mild cognitive impairment led to
   attention-related improvements and neuroplastic changes: Results from a
   9-month randomized control trial
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Mindfulness; Meditation; RCT; Cognitive enhancement; Attention; Cortical
   thickness; Neuroplasticity; Mild cognitive impairment
AB Mindfulness-based interventions can enhance cognitive abilities among older adults, thereby effectively delaying cognitive decline. These cognitive enhancements are theorized to accompany neuroplastic changes in the brain. However, this mindfulness-associated neuroplasticity has yet to be documented adequately. A randomized controlled trial was carried out among participants with mild cognitive impairment (MCI) to examine the effects of a mindfulness-based intervention on various cognitive outcomes and cortical thickness (CT) in the context of age-related cognitive impairment. Participants were assigned to a mindfulness awareness program (MAP)(n = 27) and an active control condition - health education program (n = 27). In both, they attended weekly sessions for three months and subsequently, monthly sessions for six months. Cognitive assessments and structural scans were carried out across three time-points. Whole brain analyses on CT were carried out and were supplemented with region of interest-based analyses. ROI values and cognitive outcomes were analyzed with mixed MANOVAs and followed up with univariate ANOVAs. Nine-month MAP-associated gains in working memory span and divided attention, along with an increased CT in the right frontal pole and decreased CT in the left anterior cingulate were observed. Three-month MAP-associated CT increase was observed in the left inferior temporal gyrus but did not sustain thereafter. MAP led to significant cognitive gains and various CT changes. Most of these neurobehavioral changes, may require sustained effort across nine months, albeit at a reduced intensity. MAP can remediate certain cognitive impairments and engender neuroplastic effects even among those with MCI.
C1 [Yu, Junhong; Feng, Lei; Fam, Johnson; Kua, Ee Heok; Mahendran, Rathi] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Mind Sci Ctr, Singapore, Singapore.
   [Rawtaer, Iris] Sengkang Gen Hosp, Singhealth Duke Nus Acad Med Ctr, Dept Psychiat, Singapore, Singapore.
   [Mahendran, Rathi] Duke NUS Med Sch, Acad Dev Dept, 8 Coll Rd, Singapore, Singapore.
   [Kumar, Alan Prem] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore.
   [Kumar, Alan Prem] Natl Univ Singapore, Yong Loo Lin Sch Med, Med Sci Cluster, Singapore, Singapore.
   [Cheah, Irwin Kee-Mun] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore.
   [Honer, William G.; Su, Wayne] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
   [Lee, Yuan Kun] Natl Univ Singapore Hosp, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore, Singapore.
   [Tan, Ene Choo] KK Womens & Childrens Hosp, KK Res Lab, Singapore, Singapore.
   [Tan, Ene Choo] SingHlth Duke NUS Paediat Acad Clin Program, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; National University of Singapore;
   National University of Singapore; University of British Columbia;
   National University of Singapore; KK Women's & Children's Hospital
RP Yu, JH (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Res Dry Labs North MD1, 12-01,12 Sci Dr 2, Singapore 117549, Singapore.; Mahendran, R (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, NUHS Tower Block,Level 9,1E Kent Ridge Rd, Singapore 119228, Singapore.
EM pcmyj@nus.edu.sg; pcmrathi@nus.edu.sg
RI Yu, Junhong/AFL-7994-2022; Cheah, Irwin K/ABQ-9004-2022; Kumar, Alan
   Prem/ABE-7492-2020
OI Yu, Junhong/0000-0002-2563-9658; Cheah, Irwin K/0000-0001-9817-468X;
   Kumar, Alan Prem/0000-0002-3754-5712; Rawtaer, Iris/0000-0002-8214-6454;
   Su, Wayne/0000-0001-9127-9008
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NR 30
TC 18
Z9 18
U1 3
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD MAR
PY 2021
VL 135
BP 203
EP 211
DI 10.1016/j.jpsychires.2021.01.032
EA JAN 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA QL9RR
UT WOS:000621418500001
PM 33497874
DA 2023-08-17
ER

PT J
AU Yao, XY
   Wang, YD
   Zhou, Y
   Li, Z
AF Yao, Xiuyu
   Wang, Yidan
   Zhou, Ying
   Li, Zheng
TI A nurse-led positive psychological intervention among elderly
   community-dwelling adults with mild cognitive impairment and depression:
   A non-randomized controlled trial
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE community; depression; intervention; mild cognitive impairment; positive
   psychology
ID PROBLEM ADAPTATION THERAPY; OLDER-ADULTS; NEUROPSYCHIATRIC SYMPTOMS;
   MAJOR DEPRESSION; METAANALYSIS; DEMENTIA; ANXIETY; PEOPLE; RISK
AB Background: Older adults with mild cognitive impairment (MCI) and depression have a higher dementia conversion rate, which requires timely intervention.
   Objectives: A non-randomized controlled trial was conducted to explore the effect of a nurse-led positive psychological intervention (PPI) in relieving depression and promoting cognition in this population.
   Methods: A total of 70 older adults were enrolled, with 35 each in the intervention and control groups. The control group received one-to-one health education, and the intervention group received a 40- to 60-minute PPI for eight successive weeks.
   Results: During the intervention, most participants reached the standard of active participation, and 2.86% continued to complete homework every day during follow-up. The Patient Health Questionnaire-9 (PHQ-9) score in the intervention group was significantly lower than that in the control group at the end of intervention (t = -3.64, p < 0.05) and at 3-month follow-up (t = -4.48, p < 0.05). Interaction effects of time and group on PHQ-9 scores (F = 8.11, p < 0.001), with significant differences between the groups in scores (F = 9.11, p < 0.05) and times (F = 23.58, p < 0.05) was observed. In the Montreal Cognitive Assessment (MoCA) scale, the intervention group had significantly higher scores than controls at the end of intervention (t = 7.28, p < 0.05) and 3-month follow-up (t = 8.01, p < 0.05). Cognition in the two groups was significantly affected by intergroup effects (F = 42.80, p < 0.001), interaction effects (F = 30.38, p < 0.001), and time effects (F = 33.67, p < 0.05).
   Conclusions: Although the effects tended to decrease in follow-up, the nurse-led PPI was feasible and valid in relieving depression and promoting cognition among older participants with MCI and depression. The present findings warrant further exploration.
   Tweetable abstract: A nurse-led positive psychological intervention was applicable among elderly MCI adults with depression and effective in relieving depression and promoting cognition.
C1 [Yao, Xiuyu; Wang, Yidan; Zhou, Ying; Li, Zheng] Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, Beijing, Peoples R China.
   [Li, Zheng] Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, 33 Ba Da Chu Rd, Beijing 100144, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College
RP Li, Z (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, 33 Ba Da Chu Rd, Beijing 100144, Peoples R China.
EM zhengli@pumc.edu.cn
OI Zhou, Ying/0000-0002-0959-9529
FU Peking Union Medical College
FX Peking Union Medical College
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NR 54
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD JUN
PY 2023
VL 38
IS 6
AR e5951
DI 10.1002/gps.5951
PG 14
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA K5IW2
UT WOS:001016784100001
PM 37345351
DA 2023-08-17
ER

PT J
AU Oh, H
   Park, J
   Seo, W
AF Oh, HyunSoo
   Park, JongSuk
   Seo, WhaSook
TI Development of an Evidence-Based Intervention Program for Patients With
   Mild Cognitive Impairment After Stroke: A Home-Based, Online Cognitive
   Rehabilitation Program
SO TOPICS IN GERIATRIC REHABILITATION
LA English
DT Article
DE cognitive impairment; home cares; rehabilitation; stroke
ID NO DEMENTIA; PROFILE; TOOL
AB This study was conducted to develop a home-based, online cognitive rehabilitation program that can be easily and repeatedly implemented and integrates cognitive training into daily activities. A program was devised in 3 stages: analysis, design, and development. Specific program contents were determined on the basis of needs assessment and systematic literature review. The developed program consists of general information about stroke, outlines of cognitive impairments, strategies and guidelines of the cognitive rehabilitation program, and a cognitive training workbook. The program appeared to be helpful as determined by validity testing and was found to be satisfactory by users.
C1 [Oh, HyunSoo; Seo, WhaSook] Inha Univ, Coll Med, Dept Nursing, YongHyun Dong 253, Incheon 402751, South Korea.
   [Park, JongSuk] Inha Univ Hosp, Clin Planning & Business Team, Incheon, South Korea.
C3 Inha University; Inha University; Inha University Hospital
RP Seo, W (corresponding author), Inha Univ, Coll Med, Dept Nursing, YongHyun Dong 253, Incheon 402751, South Korea.
EM wschang@inha.ac.kr
FU Inha University; National Research Foundation of Korea [49786]
FX This work was supported by Inha University Research Grant and
   Fundamental Research Fund (No. 49786) of the National Research
   Foundation of Korea.
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Z9 3
U1 3
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0882-7524
EI 1550-2414
J9 TOP GERIATR REHABIL
JI Top. Geriatr. Rehabil.
PD APR-JUN
PY 2017
VL 33
IS 2
BP 140
EP 151
DI 10.1097/TGR.0000000000000149
PG 12
WC Gerontology; Rehabilitation
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Rehabilitation
GA EV4MU
UT WOS:000401735400010
DA 2023-08-17
ER

PT J
AU Levy, SA
   Smith, G
   De Wit, L
   DeFeis, B
   Ying, G
   Amofa, P
   Locke, D
   Shandera-Ochsner, A
   McAlister, C
   Phatak, V
   Chandler, M
AF Levy, Shellie-Anne
   Smith, Glenn
   De Wit, Liselotte
   DeFeis, Brittany
   Ying, Gelan
   Amofa, Priscilla
   Locke, Dona
   Shandera-Ochsner, Anne
   McAlister, Courtney
   Phatak, Vaishali
   Chandler, Melanie
TI Behavioral Interventions in Mild Cognitive Impairment (MCI): Lessons
   from a Multicomponent Program
SO NEUROTHERAPEUTICS
LA English
DT Review
DE Behavioral interventions; Mild cognitive impairment; HABIT (R);
   Comparative effectiveness
ID FUNCTIONAL-ACTIVITIES; ALZHEIMERS-DISEASE; OLDER-ADULTS; MEMORY;
   FACTORIAL; DEMENTIA; OUTCOMES; VERSION; SCALE; ASSOCIATION
AB Comparative effectiveness of behavioral interventions to mitigate the impacts of degeneration-based cognitive decline is not well understood. To better address this gap, we summarize the studies from the Healthy Action to Benefit Independence & Thinking (HABIT (R)) program, developed for persons with mild cognitive impairment (pwMCI) and their partners. HABIT (R) includes memory compensation training, computerized cognitive training (CCT), yoga, patient and partner support groups, and wellness education. Studies cited include (i) a survey of clinical program completers to establish outcome priorities; (ii) a five-arm, multi-site cluster randomized, comparative effectiveness trial; (iii) and a three-arm ancillary study. PwMCI quality of life (QoL) was considered a high-priority outcome. Across datasets, findings suggest that quality of life was most affected in groups where wellness education was included and CCT withheld. Wellness education also had greater impact on mood than CCT. Yoga had a greater impact on memory-dependent functional status than support groups. Yoga was associated with better functional status and improved caregiver burden relative to wellness education. CCT had the greatest impact on cognition compared to yoga. Taken together, comparisons of groups of program components suggest that knowledge-based interventions like wellness education benefit patient well-being (e.g., QoL and mood). Skill-based interventions like yoga and memory compensation training aid the maintenance of functional status. Notably, better adherence produced better outcomes. Future personalized intervention approaches for pwMCI may include different combinations of behavioral strategies selected to optimize outcomes prioritized by patient values and preferences.
C1 [Levy, Shellie-Anne; Smith, Glenn; De Wit, Liselotte; DeFeis, Brittany; Ying, Gelan; Amofa, Priscilla] Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32653 USA.
   [Locke, Dona] Mayo Clin, Div Neuropsychol, Scottsdale, AZ USA.
   [Shandera-Ochsner, Anne; McAlister, Courtney] Mayo Clin Hlth Syst, Dept Psychiat & Psychol, La Crosse, WI USA.
   [Phatak, Vaishali] Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE USA.
   [Chandler, Melanie] Mayo Clin, Dept Psychiat & Psychol, Jacksonville, FL 32224 USA.
C3 State University System of Florida; University of Florida; Mayo Clinic;
   Mayo Clinic Phoenix; University of Nebraska System; University of
   Nebraska Medical Center; Mayo Clinic
RP Levy, SA (corresponding author), Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32653 USA.
EM stlevy@phhp.ufl.edu
RI Ying, Gelan/GXG-3491-2022
OI DeFeis, Brittany/0000-0003-2763-7098
FU Patient-Centered Outcomes Research Institute (PCORI) Award
   [CER-1306-01897]
FX Research reported in this manuscript was partially funded through a
   Patient-Centered Outcomes Research Institute (PCORI) Award
   (CER-1306-01897). The statements in this publication are solely the
   responsibility of the authors and do not necessarily represent the views
   of the Patient-Centered Outcomes Research Institute (PCORI), its Board
   of Governors or Methodology Committee. Trial Registration:
   ClinicalTrials.gov Identifier, NCT02265757, and peace of mind studies.
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NR 60
TC 1
Z9 1
U1 6
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1933-7213
EI 1878-7479
J9 NEUROTHERAPEUTICS
JI Neurotherapeutics
PD JAN
PY 2022
VL 19
IS 1
SI SI
BP 117
EP 131
DI 10.1007/s13311-022-01225-8
EA APR 2022
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 1M4AL
UT WOS:000781699900002
PM 35415779
OA Bronze, Green Published
DA 2023-08-17
ER

PT J
AU Li, FZ
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AF Li, Fuzhong
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   Voit, Jan
   Chou, Li-Shan
TI Implementing an Online Virtual Falls Prevention Intervention During a
   Public Health Pandemic for Older Adults with Mild Cognitive Impairment:
   A Feasibility Trial
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE cognitive function; dual-task; incidental falls; elderly; exercise;
   e-health
ID TAI-JI-QUAN; PHYSICAL PERFORMANCE; RISK; STABILITY; DEMENTIA; BALANCE;
   GAIT
AB Purpose: This study evaluates the feasibility of delivering a virtual (online) falls prevention intervention for older adults with mild cognitive impairment (MCI).
   Methods: Community-dwelling older adults with MCI (mean age = 76.2 years, 72% women) were randomized to either a Tai Ji Quan (n = 15) or stretching group (n = 15) and participated in 60-minute virtual exercise sessions, via Zoom, twice weekly for 24 weeks. The primary outcome was the incidence of falls. Secondary outcomes were the number of fallers and changes from baseline in the 4-Stage Balance Test, 30-second chair stands, and Timed Up and Go Test under both single- and dual-task conditions.
   Results: The intervention was implemented with good fidelity, an overall attendance rate of 79%, and 13% attrition. Compared with stretching, Tai Ji Quan did not reduce falls (incidence rate ratio = 0.58; 95% confidence interval [CI], 0.32 to 1.03) or the number of fallers (relative risk ratio = 0.75; 95% CI, 0.46 to 1.22) at week 24. The Tai Ji Quan group, however, performed consistently better than the stretching group in balance (between-group difference in change from baseline, 0.68 points; 95% CI, 0.12 to 1.24), 30-second chair stands (1.87 stands; 95% CI, 1.15 to 2.58), and Timed Up and Go under single-task (-1.15 seconds; 95% CI, -1.85 to -0.44) and dual-task (-2.35; 95% CI, -3.06 to -1.64) conditions. No serious intervention-related adverse events were observed.
   Conclusion: Findings from this study suggest the feasibility, with respect to intervention fidelity, compliance, and potential efficacy, of implementing an at-home, virtual, interactive Tai Ji Quan program, delivered in real-time, as a potential balance training and falls prevention intervention for older adults with MCI. The study provides preliminary data to inform future trials.
C1 [Li, Fuzhong] Oregon Res Inst, 1776 Millrace Dr, Eugene, OR 97403 USA.
   [Harmer, Peter] Willamette Univ, Dept Exercise & Hlth Sci, Salem, OR USA.
   [Voit, Jan] Voit Better Balance, Seattle, WA USA.
   [Chou, Li-Shan] Iowa State Univ, Dept Kinesiol, Ames, IA USA.
C3 Oregon Research Institute; Willamette University; Iowa State University
RP Li, FZ (corresponding author), Oregon Res Inst, 1776 Millrace Dr, Eugene, OR 97403 USA.
EM fuzhongl@ori.org
OI Chou, Li-Shan/0000-0002-2777-7034; Li, Fuzhong/0000-0001-6644-4702
FU National Institute on Aging [3R01AG059546-02S1]
FX The study reported in this manuscript was supported by the National
   Institute on Aging (3R01AG059546-02S1). The opinions expressed are those
   of the authors and do not necessarily represent the official views of
   the National Institute on Aging. The authors of this paper reported no
   other conflicts of interest.
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NR 42
TC 20
Z9 21
U1 5
U2 17
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2021
VL 16
BP 973
EP 983
DI 10.2147/CIA.S306431
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA SH7XU
UT WOS:000654347700001
PM 34079243
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Li, MY
   Li, W
   Gao, YM
   Chen, YJ
   Bai, D
   Weng, JX
   Du, Y
   Ma, F
   Wang, XY
   Liu, H
   Huang, GW
AF Li, Mengyue
   Li, Wen
   Gao, Yiming
   Chen, Yongjie
   Bai, Dong
   Weng, Jinxi
   Du, Yue
   Ma, Fei
   Wang, Xinyan
   Liu, Huan
   Huang, Guowei
TI Effect of folic acid combined with docosahexaenoic acid intervention on
   mild cognitive impairment in elderly: a randomized double-blind,
   placebo-controlled trial
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Folic acid; Docosahexaenoic acid; Mild cognitive impairment; Randomized
   double-blind; placebo-controlled trial; Liner mixed models; Inflammatory
   cytokines
ID ONSET ALZHEIMERS-DISEASE; NITRIC-OXIDE; SERUM-LEVELS; DHA;
   NEUROINFLAMMATION; SUPPLEMENTATION; PREVENTION; PATHOLOGY; VITAMINS;
   DECLINE
AB Purpose This study aimed to assess the effects of folic acid (FA) combined with a docosahexaenoic acid (DHA) intervention on the cognitive function and inflammatory cytokines in elderly subjects with mild cognitive impairment (MCI). Methods This randomized, double-blind, placebo-controlled trial recruited 240 individuals with MCI in Tianjin, China, and randomly allocated into 4 groups: FA + DHA (FA 800 mu g/d + DHA 800 mg/d), FA (FA 800 mu g/d), DHA (DHA 800 mg/d), and placebo. Cognitive function, serum folate and homocysteine (Hcy), plasma DHA and inflammatory cytokines levels were measured at baseline and 6 months. Results Daily oral FA, DHA and their combined use for 6 months significantly improved the full-scale intelligence quotient (FSIQ) and some subtests of Wechsler Adult Intelligence Scale compared to the placebo. The increases of FSIQ, arithmetic, picture completion scores in the FA group and picture completion, block design scores in the DHA group were significantly less than that in the FA combined DHA group (P < 0.05). Meanwhile, daily oral FA, DHA and their combined use for 6 months significantly decreased plasma inflammatory cytokines compared to the placebo. The changes of interleukin-1 beta levels in the FA group and interleukin-6 levels in the DHA group were significantly less than that in the FA + DHA group (P < 0.05). Conclusions Daily oral FA, DHA and their combined use for 6 months can significantly improve cognitive function and decrease plasma inflammatory cytokines in MCI individuals. The combination of FA and DHA was more beneficial than each individual nutrient on their own.
C1 [Li, Mengyue; Li, Wen; Gao, Yiming; Bai, Dong; Wang, Xinyan; Liu, Huan; Huang, Guowei] Tianjin Med Univ, Sch Publ Hlth, Dept Nutr & Food Sci, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China.
   [Gao, Yiming] Hujiayuan Community Hlth Serv Ctr Binhai New Area, Tianjin, Peoples R China.
   [Chen, Yongjie; Ma, Fei] Tianjin Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Tianjin, Peoples R China.
   [Bai, Dong] Tianjin First Cent Hosp, Dept Nutr, Tianjin, Peoples R China.
   [Weng, Jinxi] Xinkaihe Community Hlth Serv Ctr, Tianjin, Peoples R China.
   [Du, Yue] Tianjin Med Univ, Sch Publ Hlth, Dept Social Med & Hlth Management, Tianjin, Peoples R China.
   [Li, Mengyue; Li, Wen; Chen, Yongjie; Du, Yue; Ma, Fei; Wang, Xinyan; Liu, Huan; Huang, Guowei] Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Tianjin Medical
   University; Tianjin Medical University
RP Liu, H; Huang, GW (corresponding author), Tianjin Med Univ, Sch Publ Hlth, Dept Nutr & Food Sci, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China.; Liu, H; Huang, GW (corresponding author), Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin, Peoples R China.
EM liuhuan@tmu.edu.cn; huangguowei@tmu.edu.cn
RI Bai, Dong/K-2622-2018
OI Bai, Dong/0000-0001-7116-721X
FU Nutritional science research foundation from BY-HEALTH [TY0151102];
   National Natural Science Foundation of China [81730091]
FX Supported by Nutritional science research foundation from BY-HEALTH (No.
   TY0151102) and National Natural Science Foundation of China (No.
   81730091). The intervention used in the study was produced by BY-HEALTH.
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NR 43
TC 16
Z9 16
U1 3
U2 22
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2021
VL 60
IS 4
BP 1795
EP 1808
DI 10.1007/s00394-020-02373-3
EA AUG 2020
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SF0TU
UT WOS:000563227500001
PM 32856190
DA 2023-08-17
ER

PT J
AU Wang, C
   Yu, JT
   Wang, HF
   Tan, CC
   Meng, XF
   Tan, L
AF Wang, Chong
   Yu, Jin-Tai
   Wang, Hui-Fu
   Tan, Chen-Chen
   Meng, Xiang-Fei
   Tan, Lan
TI Non-Pharmacological Interventions for Patients with Mild Cognitive
   Impairment: A Meta-Analysis of Randomized Controlled Trials of
   Cognition-Based and Exercise Interventions
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Cognition-based intervention; cognitive function; exercise;
   meta-analysis; mild cognitive impairment; non-pharmacological
   interventions
ID OLDER-ADULTS; ALZHEIMERS-DISEASE; EXECUTIVE FUNCTIONS;
   PHYSICAL-ACTIVITY; AEROBIC EXERCISE; CLINICAL-TRIALS; MEMORY; DEMENTIA;
   HETEROGENEITY; DEFICITS
AB Background: Non-pharmacological interventions, including cognition-based intervention and physical exercise, are available for mild cognitive impairment (MCI), but their efficacy remains uncertain.
   Objective: To evaluate efficacy of cognition-based intervention and physical exercise on cognitive domains in patients with MCI.
   Methods: We searched MEDLINE, EMBASE, the Cochrane library, and BIOSIS previews to identify randomized controlled trials (RCTs) that involved cognition-based intervention and physical exercise for persons who were diagnosed with MCI. The pooled weight mean difference or standard mean difference (SMD) were calculated using a random-effect model.
   Results: We found significant effects of cognition-based intervention on global cognitive function (SMD 0.37 [0.07, 0.68] p = 0.02). Besides, cognition-based intervention produced significant effects on executive function reported with TMT-B (SMD 0.8 [0.09, 1.5] p = 0.03) and delayed memory (SMD 0.31 [0.01, 0.61] p = 0.05). A beneficial improvement in global cognitive function was also seen in the exercise group compared to the control group (SMD 0.25 [0.08, 0.41] p = 0.003).
   Conclusions: Both of cognition-based intervention and physical exercise had the potential to improve global cognitive function. Weak evidence of improvements was also observed for the domains of executive function and delayed memory following cognition-based intervention. Nevertheless, future standard RCTs are still needed to identify the clinical value of our results.
C1 [Wang, Chong; Yu, Jin-Tai; Tan, Chen-Chen; Meng, Xiang-Fei; Tan, Lan] Qingdao Univ, Qingdao Municipal Hosp, Sch Med, Dept Neurol, Qingdao 266071, Shandong, Peoples R China.
   [Yu, Jin-Tai; Wang, Hui-Fu; Tan, Lan] Nanjing Med Univ, Qingdao Municipal Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China.
C3 Qingdao Municipal Hospital; Qingdao University; Nanjing Medical
   University
RP Tan, L (corresponding author), Qingdao Univ, Qingdao Municipal Hosp, Sch Med, Dept Neurol, 5 Donghai Middle Rd, Qingdao 266071, Shandong, Peoples R China.
EM yu-jintai@163.com; dr.tanlan@163.com
RI Meng, Xiangfei/I-6715-2019; Yu, Jin-Tai/HDL-7766-2022
OI Yu, Jin-Tai/0000-0002-7686-0547
FU National Natural Science Foundation of China [81000544, 81171209,
   81371406]; Shandong Provincial Natural Science Foundation, China
   [ZR2010HQ004, ZR2011HZ001]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81000544, 81171209, 81371406) and Shandong
   Provincial Natural Science Foundation, China (ZR2010HQ004, ZR2011HZ001).
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NR 46
TC 57
Z9 62
U1 2
U2 37
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2014
VL 42
IS 2
BP 663
EP 678
DI 10.3233/JAD-140660
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA AO7ZP
UT WOS:000341572000028
PM 24927709
DA 2023-08-17
ER

PT J
AU Tan, RS
   Pu, SJ
   Culberson, JW
AF Tan, RS
   Pu, SJ
   Culberson, JW
TI Role of androgens in mild cognitive impairment and possible
   interventions during andropause
SO MEDICAL HYPOTHESES
LA English
DT Article
ID DEHYDROEPIANDROSTERONE-SULFATE CONCENTRATIONS; CEREBRAL
   GLUCOSE-METABOLISM; ALZHEIMERS-DISEASE; AMYLOID PROTEIN; TESTOSTERONE;
   MEMORY; DHEAS; BRAIN; PRECURSOR; NEUROSTEROIDS
AB Mild cognitive impairment (MCI) is becoming fashionable as a diagnosis, representing a state of cognitive decline associated with negligible functional loss. MCI is important as it often precedes Alzheimer's disease (AD). Recognizing MCI may lead to preventive strategies that can delay the onset of AD. Many patients who transition into andropause report problems with their memory. There is strong evidence from basic sciences and epidemiological studies that both estrogens and-androgens play a protective role in neurodegeneration. The evidence from small prospective clinical trials lends support to the role of hormones in improving cognitive function. The improvement in cognitive function with hormones is subtle and often not measurable on standard neuropsychological batteries. Patients have reported memory improvements in both declarative and procedural domains after being on hormonal replacement. Functional changes and vascular changes can be detected after hormonal replacement with more sophisticated imaging of the brain like positron emission tomography (PET) scans. We hypothesize androgens and perhaps selective androgen receptor modulators as future treatment options for MCI in aging males. (C) 2003 Elsevier Science Ltd. All rights reserved.
C1 Univ Texas, Dept Family & Community Med, Geriatr Med Program, Houston, TX 77030 USA.
   Univ Texas, Dept Family & Community Med, Mens Hlth Program, Houston, TX 77030 USA.
C3 University of Texas System; University of Texas System
RP Tan, RS (corresponding author), Univ Texas, Dept Family & Community Med, Geriatr Med Program, 6431 Fannin St,JJL Suite 308, Houston, TX 77030 USA.
EM robert.s.tan@uth.tmc.edu
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NR 46
TC 14
Z9 17
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAR
PY 2003
VL 60
IS 3
BP 448
EP 452
DI 10.1016/S0306-9877(02)00447-4
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 648LD
UT WOS:000181152100028
PM 12581627
DA 2023-08-17
ER

PT J
AU Meng, QY
   Yin, HR
   Wang, S
   Shang, BH
   Meng, XF
   Yan, ML
   Li, GC
   Chu, JF
   Chen, L
AF Meng, Qiuyan
   Yin, Huiru
   Wang, Shuo
   Shang, Binghan
   Meng, Xiangfei
   Yan, Mingli
   Li, Guichen
   Chu, Jianfeng
   Chen, Li
TI The effect of combined cognitive intervention and physical exercise on
   cognitive function in older adults with mild cognitive impairment: a
   meta-analysis of randomized controlled trials
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Cognitive dysfunction; Older adults; Cognitive intervention; Exercise;
   Cognition
ID AEROBIC EXERCISE; DEMENTIA; DISORDERS; EFFICACY
AB Background The state of mild cognitive impairment (MCI) provides an optimal window for preventing progression to dementia. Combined cognitive intervention and physical exercise may yield additive and synergistic effects on cognition in older adults with MCI. Objectives The purpose of this study was to assess the efficacy of a combined intervention to improve cognition in older adults with MCI by comparing a control group that underwent only cognitive intervention, a control group that underwent only physical exercise, and a control group that did not undergo cognitive intervention or physical exercise. Design Meta-analysis of randomized controlled trials (RCTs). Data sources The online databases of PubMed, Web of Science, Embase, the Cochrane Library, PsycINFO, and CINAHL were systematically searched. Review methods The outcomes were global cognition, memory, and executive function/attention. A sensitivity analysis was conducted when the I-2 statistic was > 50%. Results A total of 16 studies were included. The results showed that the combined intervention had positive effects on global cognition compared to the effects of the other control group [SMD = 0.27, 95% CI (0.09, 0.44), p = 0.003]. Regarding memory, the combined intervention had positive effects compared to the effects observed in the single physical exercise group [SMD = 0.25, 95% CI (0.07, 0.44), p = 0.006] and the other control group [SMD = 0.29, 95% CI (0.12, 0.47), p = 0.001]. For executive function/attention, the combined intervention had also positive effects compared to the effects of the single cognitive intervention group [SMD = 0.28, 95% CI (0.09, 0.47), p = 0.004], the single physical exercise group [SMD = 0.32, 95% CI (0.16, 0.49), p = 0.0002], and the other control group [SMD = 0.23, 95% CI (0.05, 0.41), p = 0.01]. Conclusions The combined intervention resulted in cognitive benefits in older adults with MCI and exhibited limited superiority over the single cognitive intervention and the single physical exercise on cognitive subdomains.
C1 [Meng, Qiuyan; Yin, Huiru; Wang, Shuo; Meng, Xiangfei; Yan, Mingli; Li, Guichen; Chen, Li] Jilin Univ, Sch Nursing, 965 Xinjiang Rd, Changchun 130021, Peoples R China.
   [Shang, Binghan] Henan Prov Peoples Hosp, Zhengzhou, Peoples R China.
   [Chu, Jianfeng] Jilin Univ, Sch Comp Sci & Technol, 2699 Qianjin St, Changchun 130012, Peoples R China.
   [Chen, Li] Jilin Univ, Coll Basic Med Sci, Dept Pharmacol, 126 Xinmin St, Changchun 130000, Peoples R China.
C3 Jilin University; Zhengzhou University; Jilin University; Jilin
   University
RP Chen, L (corresponding author), Jilin Univ, Sch Nursing, 965 Xinjiang Rd, Changchun 130021, Peoples R China.; Chu, JF (corresponding author), Jilin Univ, Sch Comp Sci & Technol, 2699 Qianjin St, Changchun 130012, Peoples R China.; Chen, L (corresponding author), Jilin Univ, Coll Basic Med Sci, Dept Pharmacol, 126 Xinmin St, Changchun 130000, Peoples R China.
EM chujf@jlu.edu.cn; chen_care@126.com
RI liang, liang/IAO-8518-2023
OI Li, Guichen/0000-0003-3872-5296
FU Health and Family Planning Committee of Jilin Province, China
   [2020J036]; Education Department of Jilin Province, China [2015J505]
FX This work was supported by the Health and Family Planning Committee of
   Jilin Province, China [grant numbers 2020J036] and the Education
   Department of Jilin Province, China [grant numbers 2015J505]. I would
   like to thank the organizations for funding my research.
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NR 46
TC 16
Z9 16
U1 4
U2 24
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD FEB
PY 2022
VL 34
IS 2
SI SI
BP 261
EP 276
DI 10.1007/s40520-021-01877-0
EA AUG 2021
PG 16
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA ZA0SI
UT WOS:000684497700001
PM 34383248
DA 2023-08-17
ER

PT J
AU Xu, SF
   Meng, GL
   Chen, PF
   Fang, M
   Jin, AP
AF Xu, Shaofang
   Meng, Guilin
   Chen, Pengfei
   Fang, Min
   Jin, Aiping
TI Multidimensional intervention in individuals with mild cognitive
   impairment: a pilot nonrandomized study
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE International Classification of Functioning; Disability and Health
   (ICF); mild cognitive impairment; multidimensional intervention;
   short-term effect
ID ALZHEIMERS-DISEASE; DEMENTIA; DIAGNOSIS; SHANGHAI
AB Background: There is an increasing need for non-pharmacological treatments that can enhance the cognitive function of individuals with mild cognitive impairment. We firstly performed multidimensional intervention based on the concept of the International Classification of Functioning, Disability and Health, and aimed to explore its short-term effect on the improvement of cognitive function in individuals with mild cognitive impairment.
   Methods: Twenty-four individuals with mild cognitive impairment in this pilot study were recruited from the memory clinic and neurology ward in Shanghai Tenth People's Hospital from August 2018 to August 2019. According to participants' personal wishes, 13 and 11 participants were enrolled into an intervention group and a control group, respectively. Based on the International Classification of Functioning, Disability and Health, we performed baseline assessments to all participants. According to the assessment results and the wishes and hobbies of the patients, then doctors, therapists, nurses, patients and their families together chose the appropriate multidimensional interventions to the intervention group in seven 1-hour sessions and health education to the both groups. After one week, all participants underwent reevaluation of cognitive function.
   Results: There were significant differences between the two groups on the improvement of cognitive function. The intervention group (mean +/- SD, 3.460 +/- 1.613) scored higher than the control group (1.360 +/- 0.924) on the change score of the total score in the Montreal Cognitive Assessment (t =3.808, P<0.001, 95% CI: 0.955-3.240), though not on the change score of any cognitive domain score. Regression results showed that the change score of the total score was negatively correlated with the baseline score of Abstraction score (aR2 =0.583, beta =-0.506, P=0.031) and the modified Barthel index score (beta =-0.464, P=0.045) in the intervention group.
   Conclusions: The pilot study demonstrated that the short-term multidimensional intervention may produce cognitive benefits in individuals with mild cognitive impairment.
C1 [Xu, Shaofang; Meng, Guilin; Chen, Pengfei; Jin, Aiping] Tongji Univ, Shanghai Peoples Hosp 10, Neurol Rehabil Ctr, Dept Neurol,Sch Med, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.
   [Fang, Min] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Neurol, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.
C3 Tongji University; Tongji University
RP Jin, AP (corresponding author), Tongji Univ, Shanghai Peoples Hosp 10, Neurol Rehabil Ctr, Dept Neurol,Sch Med, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.; Fang, M (corresponding author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Neurol, 301 Yanchang Middle Rd, Shanghai 200072, Peoples R China.
EM fangmin_dr@126.com; 13402140058@163.com
FU Science and Technology Commission of Shanghai Municipality [17411950101,
   18411961700, 19441908500]; Shanghai Municipal Key Clinical Specialty
   [shslczdzk06102]
FX This study was supported by the Science and Technology Commission of
   Shanghai Municipality (17411950101; 18411961700; 19441908500) and
   Shanghai Municipal Key Clinical Specialty (shslczdzk06102).
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NR 22
TC 2
Z9 2
U1 0
U2 8
PU AME PUBL CO
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD FEB
PY 2021
VL 10
IS 2
BP 1539
EP 1547
DI 10.21037/apm-20-346
PG 9
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA QQ5FV
UT WOS:000624549600059
PM 33183051
OA gold
DA 2023-08-17
ER

PT J
AU Siu, MY
   Lee, DTF
AF Siu, Mei-Yi
   Lee, Diana T. F.
TI Is Tai Chi an effective intervention for enhancing health-related
   quality of life in older people with mild cognitive impairment? An
   interventional study
SO INTERNATIONAL JOURNAL OF OLDER PEOPLE NURSING
LA English
DT Article
DE health-related quality of life; mild cognitive impairment;
   neuropsychiatric symptoms; Tai Chi
ID NEUROPSYCHIATRIC SYMPTOMS; SOCIAL RELATIONSHIPS; CHRONIC PAIN; STRESS;
   ADULTS; PROGRESSION; PREVALENCE; DEPRESSION; DEMENTIA
AB Background: Many neuropsychiatric symptoms in persons of MCI cause negative impacts on their HRQOL. There is limited HRQOL research investigating the effect of Tai Chi on older people with MCI.
   Objective: To determine the effectiveness of a Tai Chi program in enhancing healthrelated quality of life (HRQOL) among community-dwelling older people with mild cognitive impairment (MCI) in Hong Kong.
   Methods: This was a quasi-experimental study using a nonequivalent control group (CG) design. Four social centres for older people participated in the study, of which two centres were randomised for Tai Chi intervention and the other two were treated as control. Participants in the intervention group (IG) were arranged for a 1-hour Tai Chi class twice weekly for 16 weeks, whereas participants in the CG were advised to join various recreational activities in the social centres as usual. For outcome evaluation, the Chinese version of the Short Form-12 Health Survey-Standard 1 (SF-12) was employed to assess participants' perceived HRQOL.
   Results: One hundred and sixty participants were recruited (IG = 80, CG = 80). Data were collected at baseline (TO) and 16-week post-intervention (T1).The IG reported significant improvement in the physical health component (PCS) (p = .036), the mental health component (MCS) (p = .014), as well as several subscales of SF-12, namely, the role-physical (RP) (p = .044), the bodily pain (BP) (p < .001) and the vitality (VT) (p = .004) subscales, in comparison with the CG.
   Conclusion: The current study results extended our knowledge about Tai Chi of which the mind-body exercise could enhance the physical and psychosocial well-being in older people with MCI.
   Implications for practice: The findings have the potential to inform health and social care professionals to promote Tai Chi in community settings, as it may represent a non-intensive and age-fitting strategy to promote HRQOL in older people with MCI.
C1 [Siu, Mei-Yi] Union Hosp, Sch Nursing, Hong Kong, Peoples R China.
   [Lee, Diana T. F.] Chinese Univ Hong Kong, Nethersole Sch Nursing, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Siu, MY (corresponding author), 21-F Citimark,28 Yuen Shun Circuit, Hong Kong, Peoples R China.
EM minniesiu@union.org
OI Siu, Mei Yi/0000-0002-3847-3263
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NR 72
TC 3
Z9 3
U1 2
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-3735
EI 1748-3743
J9 INT J OLDER PEOPLE N
JI Int. J. Older People Nurs.
PD SEP
PY 2021
VL 16
IS 5
AR e12400
DI 10.1111/opn.12400
EA JUL 2021
PG 12
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA ZI1HM
UT WOS:000672464500001
PM 34254731
DA 2023-08-17
ER

PT J
AU Horr, T
   Messinger-Rapport, B
   Pillai, JA
AF Horr, T.
   Messinger-Rapport, B.
   Pillai, J. A.
TI Systematic review of strengths and limitations of Randomized Controlled
   Trials for non-pharmacological interventions in mild cognitive
   impairment: Focus on Alzheimer's disease
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Review
DE Mild cognitive impairment; Alzheimer's disease; non-pharmacologic
   interventions; physical activity; cognitive interventions;
   socialization; randomized controlled trial; CONSORT score
ID OLDER-ADULTS; PHYSICAL-ACTIVITY; AEROBIC EXERCISE; BRAIN PLASTICITY;
   CLINICAL-TRIALS; ELDERLY-PEOPLE; WORKING-MEMORY; SAMPLE-SIZES; DEMENTIA;
   DECLINE
AB Non-pharmacological interventions may improve cognition and quality of life, reduce disruptive behaviors, slow progression from Mild Cognitive Impairment (MCI) to dementia, and delay institutionalization. It is important to look at their trial designs as well as outcomes to understand the state of the evidence supporting non-pharmacological interventions in Alzheimer's disease (AD). An analysis of trial design strengths and limitations may help researchers clarify treatment effect and design future studies of non-pharmacological interventions for MCI related to AD.
   A systematic review of the methodology of Randomized Controlled Trials (RCTs) targeting physical activity, cognitive interventions, and socialization among subjects with MCI in AD reported until March 2014 was undertaken. The primary outcome was CONSORT 2010 reporting quality. Secondary outcomes were qualitative assessments of specific methodology problems.
   23 RCT studies met criteria for this review. Eight focused on physical activity, fourteen on cognitive interventions, and one on the effects of socialization. Most studies found a benefit with the intervention compared to control. CONSORT reporting quality of physical activity interventions was higher than that of cognitive interventions. Reporting quality of recent studies was higher than older studies, particularly with respect to sample size, control characteristics, and methodology of intervention training and delivery. However, the heterogeneity of subjects identified as having MCI and variability in interventions and outcomes continued to limit generalizability.
   The role for non-pharmacological interventions targeting MCI is promising. Future studies of RCTs for non-pharmacological interventions targeting MCI related to AD may benefit by addressing design limitations.
RP Pillai, JA (corresponding author), Case Western Reserve Univ, Cleveland Clin Lerner Coll Med, Lou Ruvo Ctr Brain Hlth, 9500 Euclid Ave U10, Cleveland, OH 44195 USA.
EM pillaij@ccf.org
RI Pillai, Jagan/AAW-9673-2020
OI Pillai, Jagan/0000-0001-6784-824X
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NR 78
TC 41
Z9 41
U1 2
U2 67
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD FEB
PY 2015
VL 19
IS 2
BP 141
EP 153
DI 10.1007/s12603-014-0565-6
PG 13
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA CC4DH
UT WOS:000350300500004
PM 25651439
DA 2023-08-17
ER

PT J
AU Shao, ZF
   Hu, MY
   Zhang, D
   Zeng, XM
   Shu, XH
   Wu, XY
   Kwok, TCY
   Feng, H
AF Shao, Zhanfang
   Hu, Mingyue
   Zhang, Dou
   Zeng, Xianmei
   Shu, Xinhui
   Wu, Xinyin
   Kwok, Timothy C. Y.
   Feng, Hui
TI Dose-response relationship in non-pharmacological interventions for
   individuals with mild cognitive impairment: A systematic review and
   meta-analysis of randomised controlled trials
SO JOURNAL OF CLINICAL NURSING
LA English
DT Review
DE cognitive function; meta-analysis; mild cognitive impairment;
   non-pharmacological interventions; randomised controlled trials
ID POLYUNSATURATED FATTY-ACIDS; PHYSICAL-ACTIVITY; OLDER-ADULTS; DEMENTIA;
   EXERCISE; MANAGEMENT; DIAGNOSIS; QUALITY; DISEASE; RISK
AB Background Non-pharmacological interventions (NPIs) are important in cognitive decline prevention in individuals with mild cognitive impairment (MCI). However, the dose-response relationship remains unclear. Design Systematic review and meta-analysis of randomised controlled trials. Methods Seven databases were searched until April 2020. RCTs of NPIs in individuals with MCI were eligible for inclusion. Hedge's g was used to calculate the effect size. A random-effect meta-analysis was used to explore the impact of NPIs on cognition. Subgroup analysis was used to investigate the moderates. The dose was measured by prescription (frequency, intensity, type, time and volume) and intervention characteristics (period, energy expenditure, delivery mode and setting) in NPIs. Results Forty-two studies with 4401 participants were included. In the NPIs, cognitive intervention (g = 0.167), physical exercise (g = 0.536) and multicomponent intervention (g = 0.386) had significant effect on cognition in individuals with MCI. Dose-response results showed cognition could be significantly improved in 1-2 times/week (p < .05), 60-120 min/session (p < .05), >= 12 weeks (p < .05), supervised (p < .05), clinical setting (p < .05) in cognitive intervention. In physical exercise, cognition could be improved in >= 3 times/week (p < .05), vigorous-intensity (p < .05), muscle-strengthening activity (p < .05), 30-60 min/session (p < .05), 6-12 weeks (p < .05), unsupervised (p < .05), community setting (p < .05). In the multicomponent intervention, cognition could be improved in 1-2 times/week (p < .05), 30-60 min/session (p < .05), 8-16 weeks (p < .05), clinical (p < .05). In nutrition intervention, cognition could be better improved DHA (p < .05), >1000 mg/day (p < .05). Conclusions The effectiveness of cognitive intervention is significantly influenced by frequency, time, period, delivery mode and setting. The effectiveness of physical exercise is significantly influenced by frequency, intensity, type, time, period, delivery mode and setting. The effectiveness of multicomponent intervention is significantly influenced by frequency, time, period and setting. The effectiveness of nutrition intervention is significantly influenced by dose and type. Relevance to Clinical Practice The research summarised the evidence to guide the best prescription of NPIs and helped clinicians design more effective interventions in individuals with MCI.
C1 [Shao, Zhanfang; Hu, Mingyue; Zhang, Dou; Zeng, Xianmei; Feng, Hui] Cent South Univ, Xiangya Sch Nursing, Changsha 410083, Peoples R China.
   [Shu, Xinhui] Zhengzhou Univ, Affiliated Tumor Hosp, Tumor Hosp Henan Prov, Dept Hematol, Zhengzhou, Peoples R China.
   [Wu, Xinyin] Cent South Univ, XiangYa Sch Med, Dept Publ Hlth, Changsha, Peoples R China.
   [Kwok, Timothy C. Y.] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China.
C3 Central South University; Zhengzhou University; Central South
   University; Chinese University of Hong Kong
RP Feng, H (corresponding author), Cent South Univ, Xiangya Sch Nursing, Changsha 410083, Peoples R China.
EM feng.hui@csu.edu.cn
OI Shao, Zhanfang/0000-0001-6051-8889; Zhang, Dou/0000-0001-6604-6894
FU Special Funding for the Construction of Innovative Provinces in Hunan
   [2020SK2055]; Central South University Innovation-driven project
   [2021zzts0337, 2021zzts1017]; National Key R&D Program of China
   [2020YFC2008602, 2020YFC2008503]; China Oceanwide Holding Group Project
   Fund [143010100]
FX This work was supported by the Special Funding for the Construction of
   Innovative Provinces in Hunan (Grant No. 2020SK2055), the Central South
   University Innovation-driven project (grant number 2021zzts0337,
   2021zzts1017), the National Key R&D Program of China (grant number:
   2020YFC2008602, 2020YFC2008503), and the China Oceanwide Holding Group
   Project Fund (grant number 143010100).
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NR 49
TC 3
Z9 3
U1 3
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD DEC
PY 2022
VL 31
IS 23-24
BP 3390
EP 3401
DI 10.1111/jocn.16240
EA JAN 2022
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 6S4KD
UT WOS:000749657300001
PM 35098610
DA 2023-08-17
ER

PT J
AU Zhang, Q
   Zhu, ML
   Huang, LL
   Zhu, M
   Liu, XL
   Zhou, P
   Meng, T
AF Zhang, Qiang
   Zhu, Menglong
   Huang, Lili
   Zhu, Miao
   Liu, Xiaolei
   Zhou, Ping
   Meng, Tao
TI A Study on the Effect of Traditional Chinese Exercise Combined With
   Rhythm Training on the Intervention of Older Adults With Mild Cognitive
   Impairment
SO AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
LA English
DT Article
DE traditional Chinese exercise; rhythm training; cognitive impairment;
   cognitive function; older adults
ID PHYSICAL-ACTIVITY; ELDERLY PERSONS; MUSIC-THERAPY; DEMENTIA; PEOPLE;
   DISEASE; WALKING; MEMORY; STATE
AB BackgroundTo examine the effect of combination exercise program on cognitive function of older adults with mild cognitive impairment (MCI), and identify biomarkers associated with improvement of cognitive functions.MethodsSubjects were 42 older adults (ages, 60-80 years) with MCI. The subjects were randomly classified to traditional Chinese exercise combined with rhythm training group (TCE + RTG, n = 14), walking group (WG, n = 14), and control group (CG, n = 14), according to their level of MMSE scores. These groups exercised for 60 minutes at 1 session, 3 sessions a week for 12 weeks. The intervention program was conducted under multitask conditions to stimulate attention and memory, and the control group attended 3 education classes. Measurements were administered before, after the 6-week, and after the 12-week intervention period; Measurements: The Mini-mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Symbol Digit Modalities Test (SDMT), Activities of Daily Living Scale (ADL), and the 17-item Hamilton Depression Scale (HAMD-17), along with the brain-derived neurotrophic factor (BDNF). A repeated-measures analysis of variance was used to examine differences among the 3 groups and between the 3 testing times (pre-test vs middle-test vs post-test).Results(1) The TCE + RTG showed significant improvement in the MMSE, MoCA, SDMT, and ADL scale test results (P < .01) and HAMD-17 scale test results (P < .05). The WG also showed significant improvement in the MMSE, MoCA, and HAMD-17 scale test results (P < .05) and the ADL scale test results (P < .01). While there was no significant change in the CG after the intervention. (2) The TCE + RTG and WG showed positive improvement in peripheral blood BDNF levels, while the CG showed a decrease in these test results. There were significant differences between the TCE + RTG and CG before and after the intervention.ConclusionThe results suggested that a TCE + RT is beneficial for improving memory and maintaining general cognitive function and peripheral blood BDNF levels in older adults with MCI. Peripheral blood BDNF levels may predict improvement of cognitive functions in older adults with MCI. Further studies are required to determine the positive effects of TCE + RT on cognitive function in older adults with MCI. Trial Registration: ChiCTR2200058545, Registered 10 April 2022.
C1 [Zhang, Qiang; Zhu, Miao] Capital Univ Phys Educ & Sports, Grad Sch, Beijing, Peoples R China.
   [Zhu, Menglong] Beijing Hosp Integrated Tradit Chinese & Western M, Encephalopathy Ctr, Beijing, Peoples R China.
   [Huang, Lili] Beijing Sport Univ, Chinese Wushu Acad, Beijing, Peoples R China.
   [Liu, Xiaolei] Beijing Sport Univ, Chinese Tradit Regimen Exercise Intervent Res Ctr, Beijing, Peoples R China.
   [Zhou, Ping] Beijing Sport Univ, Sch Art, Beijing, Peoples R China.
   [Meng, Tao] Capital Univ Phys Educ & Sports, Sch Wushu & Performance, Beijing, Peoples R China.
   [Meng, Tao] Capital Univ Phys Educ & Sports, 11 North Third Ring West Rd, Beijing 100191, Peoples R China.
   [Zhou, Ping] Beijing Sport Univ, 48 Informat Rd, Beijing 100084, Peoples R China.
C3 CAPITAL UNIVERSITY OF PHYSICAL EDUCATION AND SPORTS; Beijing Sport
   University; Beijing Sport University; Beijing Sport University; CAPITAL
   UNIVERSITY OF PHYSICAL EDUCATION AND SPORTS; CAPITAL UNIVERSITY OF
   PHYSICAL EDUCATION AND SPORTS; Beijing Sport University
RP Meng, T (corresponding author), Capital Univ Phys Educ & Sports, 11 North Third Ring West Rd, Beijing 100191, Peoples R China.; Zhou, P (corresponding author), Beijing Sport Univ, 48 Informat Rd, Beijing 100084, Peoples R China.
EM zhouping0588@163.com; 1536930960@qq.com
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NR 64
TC 0
Z9 0
U1 1
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1533-3175
EI 1938-2731
J9 AM J ALZHEIMERS DIS
JI Am. J. Alzheimers Dis. Other Dement.
PD JUL
PY 2023
VL 38
AR 15333175231190626
DI 10.1177/15333175231190626
PG 12
WC Geriatrics & Gerontology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA N0LC0
UT WOS:001034024400001
PM 37489602
OA gold
DA 2023-08-17
ER

PT J
AU Gomez-Caceres, B
   Cano-Lopez, I
   Alino, M
   Puig-Perez, S
AF Gomez-Caceres, Barbara
   Cano-Lopez, Irene
   Alino, Marta
   Puig-Perez, Sara
TI Effectiveness of virtual reality-based neuropsychological interventions
   in improving cognitive functioning in patients with mild cognitive
   impairment: A systematic review and meta-analysis
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Review; Early Access
DE Mild cognitive impairment; neuropsychological intervention; virtual
   reality; cognition
ID MEMORY TRAINING-PROGRAM; OLDER-ADULTS; DEMENTIA; REHABILITATION;
   EFFICACY; BATTERY; VERSION; LIFE
AB Objective: Increased prevalence of mild cognitive impairment (MCI) has led to a need for new neuropsychological intervention tools in this population. This meta-analysis aimed to learn about the efficacy of virtual reality (VR)-based neuropsychological interventions in improving cognitive functioning in patients with MCI. Method: This review followed the recommendations of the PRISMA statement, and it was registered in PROSPERO. The studies examined were collected from the PsycINFO, Web of Science, Pubmed/MEDLINE, Embase, Scopus, and Cochrane Library databases. Results: The systematic search yielded 258 articles, of which 13 randomized controlled trials were selected. VR-based neuropsychological interventions had moderate effects on global cognition (g = 0.30; 95% CI = 0.05, 0.56; p = 0.02), small effects on attention (g = 0.27; 95% CI = 0.04, 0.49; p = 0.02), and large effects on executive function (g = 0.60; 95% CI = 0.38, 0.81; p < 0.0001), but non-significant effects on working memory, episodic memory, language, or visuoconstruction. When the length of the intervention was considered, VR-based interventions of 15 or more hours had moderate effects on working memory (g = 0.55; 95% CI = 0.11, 0.99; p = 0.01), and large effects on language (g = 0.60; 95% CI = 0.01, 1.20; p = 0.05) and visuoconstruction (g = 1.13; 95% CI = 0.58, 1.67; p < 0.0001). Conclusions: Results suggest that VR-based interventions are beneficial for improving cognitive functioning in patients with MCI, and allow us to make recommendations that could have implications for clinical decision-making in this population.
C1 [Gomez-Caceres, Barbara; Cano-Lopez, Irene; Alino, Marta; Puig-Perez, Sara] Valencian Int Univ, Fac Hlth Sci, Valencia, Spain.
   [Cano-Lopez, Irene; Alino, Marta; Puig-Perez, Sara] Valencian Int Univ, VIU NED Chair Global Neurosci & Social Change, Valencia, Spain.
   [Cano-Lopez, Irene; Alino, Marta; Puig-Perez, Sara] Valencian Int Univ, Res Grp Psychol & Qual Life PsiCal, Valencia, Spain.
C3 Universidad Internacional de Valencia VIU; Universidad Internacional de
   Valencia VIU; Universidad Internacional de Valencia VIU
RP Cano-Lopez, I (corresponding author), Valencian Int Univ, C Pintor Sorolla 21, Valencia 46002, Spain.
EM irene.cano@campusviu.es
OI Cano-Lopez, Irene/0000-0001-9447-3244; Puig Perez,
   Sara/0000-0003-0635-905X
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NR 95
TC 0
Z9 0
U1 6
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PD 2022 NOV 14
PY 2022
DI 10.1080/13854046.2022.2148283
EA NOV 2022
PG 34
WC Psychology, Clinical; Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA 6N9SD
UT WOS:000889887400001
PM 36416175
DA 2023-08-17
ER

PT J
AU Forster, S
   Buschert, VC
   Buchholz, H
   Teipel, SJ
   Zach, C
   Hampel, H
   Bartenstein, P
   Burger, K
AF Foerster, S.
   Buschert, V. C.
   Buchholz, H.
   Teipel, S. J.
   Zach, C.
   Hampel, H.
   Bartenstein, P.
   Buerger, K.
TI Effects of a 6-months stage-specific cognitive intervention program on
   brain metabolism in subjects with amnestic mild cognitive impairment
   (aMCI) and mild Alzheimer's disease (AD)
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Meeting Abstract
C1 [Foerster, S.; Zach, C.; Bartenstein, P.] Univ Munich, Dept Nucl Med LMU, Munich, Germany.
   [Buschert, V. C.; Buerger, K.] Univ Munich, Alzheimer Mem Ctr, Munich, Germany.
   [Buschert, V. C.; Buerger, K.] Univ Munich, Geriatr Psychiat Branch LMU, Munich, Germany.
   [Buchholz, H.] Johannes Gutenberg Univ Mainz, Dept Nucl Med, Mainz, Germany.
   [Teipel, S. J.] Univ Rostock, Dept Psychiat, D-18055 Rostock, Germany.
   [Hampel, H.] Univ Dublin Trinity Coll, Lab Neuroimaging & Biomarker Res, Discipline Psychiat, Dublin 2, Ireland.
C3 University of Munich; University of Munich; University of Munich;
   Johannes Gutenberg University of Mainz; University of Rostock; CHARMEU;
   Trinity College Dublin
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD SEP
PY 2009
VL 36
SU 2
BP S166
EP S167
PG 2
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA V28OT
UT WOS:000208690800045
DA 2023-08-17
ER

PT J
AU Kim, MS
   Gang, M
   Lee, J
   Park, E
AF Kim, Myung-Suk
   Gang, Moonhee
   Lee, Jihye
   Park, Eunyoung
TI The Effects of Self-Care Intervention Programs for Elderly with Mild
   Cognitive Impairment
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID DEMENTIA; HEALTH; DIAGNOSIS; VALIDATION; MANAGEMENT; VERSION
AB This study examined the effects of a self-care intervention program on self-efficacy, dementia-preventive behavior, cognitive function, depression, and quality of life in elderly with mild cognitive impairment. The study employed a quasi-experimental study design using a nonequivalent control group pre-post. Data were analyzed using the chi-square test, independent t-test, and repeated-measures ANOVA. The results of the study showed that the program reduced dementia risk and strengthened self-care ability in older adults with MCI.
C1 [Kim, Myung-Suk] Howon Univ, Dept Nursing Sci, Gunsan, Jeonbuk, South Korea.
   [Gang, Moonhee; Park, Eunyoung] Chungnam Natl Univ, Coll Nursing, Munhwa Ro 266, Daejeon 301747, South Korea.
   [Lee, Jihye] Ulsan Coll, Dept Nursing Sci, Ulsan, South Korea.
C3 Howon University; Chungnam National University; University of Ulsan
RP Gang, M (corresponding author), Chungnam Natl Univ, Coll Nursing, Munhwa Ro 266, Daejeon 301747, South Korea.
EM mhgang1014@gmail.com
RI Kim, Myung Suk/Q-3215-2019
OI Park, Eunyoung/0000-0002-2251-3582
CR American Psychiatric Association, 2000, DIAGN STAT MAN MENT, V1, DOI [10.1176/appi.books.9780890423349, 10.1176/appi.books.9780890425596]
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NR 31
TC 1
Z9 1
U1 1
U2 16
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD NOV 2
PY 2019
VL 40
IS 11
BP 973
EP 980
DI 10.1080/01612840.2019.1619202
EA JUL 2019
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA JJ5XW
UT WOS:000477280600001
PM 31322472
DA 2023-08-17
ER

PT J
AU Torpil, B
   Sahin, S
   Pekcetin, S
   Uyanik, M
AF Torpil, Berkan
   Sahin, Sedef
   Pekcetin, Serkan
   Uyanik, Mine
TI The Effectiveness of a Virtual Reality-Based Intervention on Cognitive
   Functions in Older Adults with Mild Cognitive Impairment: A
   Single-Blind, Randomized Controlled Trial
SO GAMES FOR HEALTH JOURNAL
LA English
DT Article
DE Aged; Cognition; Kinect; Rehabilitation; Virtual reality
ID MEMORY; REHABILITATION; EXERCISE
AB Objective: Mild cognitive impairment (MCI) is a broad term for people at a stage between normal age-related cognitive decline and dementia, where cognitive problems are present but do not impair activities of daily living. This study aimed at evaluating the effectiveness of a virtual reality (VR)-based rehabilitation program on cognitive functions in MCI.
   Materials and Methods: Sixty-one older adults (25 men, 36 women) with MCI were randomized to the intervention group (n = 30; 70.12 +/- 2.57 years) or control (n = 31; 70.30 +/- 2.73 years) group. The intervention group received a VR (computer-generated interactive environments) intervention in addition to a conventional cognitive rehabilitation (CR) intervention, whereas the control group received only the CR intervention. Cognitive functions were assessed in both groups before and after the 12-week interventions by using the Loewenstein Occupational Therapy Cognitive Assessment-Geriatric.
   Results: Between-group comparisons revealed significantly greater improvements in orientation, visual-spatial perception, visuomotor organization, thinking operation, and attention/concentration functions in the VR group than in the control group (P < 0.001 for all).
   Conclusion: Our results showed that 12 weeks of VR-based rehabilitation enhanced cognitive functions in older adults with MCI. Using VR applications in CR is recommended to improve cognitive functions of older adults with MCI.
C1 [Torpil, Berkan; Pekcetin, Serkan] Univ Hlth Sci Turkey, Fac Gulhane Hlth Sci, Dept Occupat Therapy, TR-06532 Ankara, Turkey.
   [Sahin, Sedef; Uyanik, Mine] Hacettepe Univ, Dept Occupat Therapy, Fac Hlth Sci, Ankara, Turkey.
C3 Hacettepe University
RP Torpil, B (corresponding author), Univ Hlth Sci Turkey, Fac Gulhane Hlth Sci, Dept Occupat Therapy, TR-06532 Ankara, Turkey.
EM berkantorpil@gmail.com
RI ŞAHİN, SEDEF/ABH-2312-2020; Pekçetin, Serkan/ADE-8723-2022; Pekçetin,
   Serkan/AAI-6455-2020; şahin, sedef/F-6307-2016; Torpil,
   Berkan/AAQ-6758-2021
OI ŞAHİN, SEDEF/0000-0002-6483-072X; Pekçetin, Serkan/0000-0001-5110-633X;
   Pekçetin, Serkan/0000-0001-5110-633X; şahin, sedef/0000-0002-6483-072X;
   Torpil, Berkan/0000-0002-0322-5163
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NR 31
TC 13
Z9 14
U1 10
U2 62
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2161-783X
EI 2161-7856
J9 GAMES HEALTH J
JI Games Health J.
PD MAR 1
PY 2021
VL 10
IS 2
BP 109
EP 114
DI 10.1089/g4h.2020.0086
EA OCT 2020
PG 6
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Rehabilitation
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Rehabilitation
GA RI3GU
UT WOS:000581557800001
PM 33058735
DA 2023-08-17
ER

PT J
AU Stott, J
   Spector, A
AF Stott, Joshua
   Spector, Aimee
TI A review of the effectiveness of memory interventions in mild cognitive
   impairment (MCI)
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Review
DE MCI; dementia; cognitive disorders; memory
ID REHABILITATION PROGRAM; ALZHEIMERS-DISEASE; OLDER-ADULTS; NO DEMENTIA;
   QUESTIONNAIRE; PERFORMANCE; BENEFITS; EFFICACY; QUALITY; PEOPLE
AB Background: Mild cognitive impairment (MCI) is commonly associated with memory impairment. There have been a number of studies attempting to ameliorate this through memory interventions including memory rehabilitation and training. The current paper reviews the evidence for the effectiveness of such interventions in enhancing learning of specific information, their impact on untrained material, compensation for memory impairment and improving everyday functioning.
   Methods: The literature was systematically searched for studies focusing on interventions targeting memory impairment in MCI using relevant search terms. Studies were screened for inclusion or exclusion using a priori criteria and, once identified, studies were examined for quality using pre-specified criteria.
   Results: A total of 226 studies were identified in the search, ten of which were included in the final review. Only one study was an RCT of "adequate" methodology. It was tentatively suggested that people with MCI can learn specific information, although there was little evidence to suggest that memory training can generalize. There was some limited evidence of ability to learn to compensate for memory difficulties and contradictory findings regarding improvement in everyday life.
   Conclusions: The poor methodological quality of the included studies implies that the ability to draw conclusions is limited. MCI is a controversial concept and there is a need for good quality trials examining the efficacy of memory interventions. There are some indications that memory impairment in MCI might best be targeted by interventions developing compensatory strategies and targeting the learning of specific information relevant to the individual.
C1 [Stott, Joshua; Spector, Aimee] UCL, Res Dept Clin Educ & Hlth Psychol, London WC1E 6BR, England.
C3 University of London; University College London
RP Stott, J (corresponding author), UCL, Res Dept Clin Educ & Hlth Psychol, 1-19 Torrington Pl, London WC1E 6BR, England.
EM j.stott@ucl.ac.uk
RI stott, josh/AAX-6275-2021
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NR 56
TC 45
Z9 46
U1 2
U2 46
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD APR
PY 2011
VL 23
IS 4
BP 526
EP 538
DI 10.1017/S1041610210001973
PG 13
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 743EC
UT WOS:000288999200003
PM 20946704
DA 2023-08-17
ER

PT J
AU Scott, TM
   Bhadelia, RA
   Qiu, WQ
   Folstein, MF
   Rosenberg, IH
AF Scott, Tammy M.
   Bhadelia, Rafeeque A.
   Qiu, Wei Qiao
   Folstein, Marshal F.
   Rosenberg, Irwin H.
TI Small Vessel Cerebrovascular Pathology Identified by Magnetic Resonance
   Imaging Is Prevalent in Alzheimer's Disease and Mild Cognitive
   Impairment: A Potential Target for Intervention
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Aging; Alzheimer's disease; cerebrovascular disease; dementia;
   homocysteine; magnetic resonance imaging; neuropsychological testing;
   small vessel pathology
ID TOTAL HOMOCYSTEINE LEVELS; WHITE-MATTER LESIONS; RANDOMIZED
   CONTROLLED-TRIAL; VASCULAR RISK-FACTORS; CARDIOVASCULAR HEALTH; PLASMA
   HOMOCYSTEINE; INVESTIGATE MEMORY; OXFORD PROJECT; AGING OPTIMA;
   OLDER-ADULTS
AB Background: There is evidence that Alzheimer's disease (AD) has significant cerebrovascular etiopathogenesis. Understanding potentially modifiable risk factors for vascular disease can help design long-term intervention strategies for controlling or preventing cognitive dysfunction attributable to cerebrovascular disease.
   Objective: To evaluate the presence and severity of markers of cerebrovascular pathology, its relationship to diagnostic categories of dementia, including AD, and association with the metabolic biomarker homocysteine.
   Methods: In a cross-sectional observational study, 340 community-dwelling elders received a clinical evaluation including brain MRI and neuropsychological tests. Dementia and mild cognitive impairment (MCI) were diagnosed by consensus committee. Fasting total plasma homocysteine was measured. Statistical analyses were adjusted for demographics and cerebrovascular risk factors.
   Results: Nearly 25% of those diagnosed with AD had small vessel infarcts (SVI). Periventricular white matter hyperintensity (pvWMHI) was prevalent in participants with AD (61%) or MCI (amnesic 61% and non-amnesic 54%, respectively). Participants with SVI and/or pvWMHI also had greater brain atrophy. Homocysteine concentrations were higher in individuals with cerebrovascular findings than in those without. In individuals with cerebrovascular disease, homocysteine was inversely related to executive function (p = 0.022) and directly related to degree of brain atrophy (p = 0.009).
   Conclusions: We demonstrated a significant prevalence of small vessel markers of cerebrovascular pathology in individuals diagnosed with AD, with a significant concurrence between cerebrovascular disease and brain and ventricular atrophy. While current research on AD has focused on amyloid-beta peptide deposition, tau-pathology, and microglial activation and inflammation, greater attention to the cerebrovascular contribution to this neurodegenerative disease presents an additional target for therapeutic prevention and intervention.
C1 [Scott, Tammy M.; Rosenberg, Irwin H.] Friedman Sch Nutr Sci & Policy, Boston, MA USA.
   [Scott, Tammy M.; Folstein, Marshal F.; Rosenberg, Irwin H.] Tufts Univ, Sch Med, Boston, MA 02111 USA.
   [Bhadelia, Rafeeque A.] Harvard Med Sch, Boston, MA USA.
   [Qiu, Wei Qiao] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Rosenberg, Irwin H.] USDA Jean Mayer Human Nutr Res Ctr Aging, Boston, MA USA.
C3 Tufts University; Harvard University; Harvard Medical School; Boston
   University; United States Department of Agriculture (USDA)
RP Scott, TM; Rosenberg, IH (corresponding author), 711 Washington St, Boston, MA 02111 USA.
EM tammy.scott@tufts.edu; irwin.rosenberg@tufts.edu
FU USDA [58-1950-0-014]; National Institute on Aging [R01AG21790-01];
   General Clinical Research Center - National Center for Research
   Resources of the NIH [MO1-RR00054]
FX Supported by the USDA (agreement 58-1950-0-014), the National Institute
   on Aging (R01AG21790-01), and General Clinical Research Center funded by
   the National Center for Research Resources of the NIH, MO1-RR00054. The
   sponsors had no role in the design and conduct of the study; in the
   collection, analysis, and interpretation of data; in the preparation of
   the manuscript; or in the review or approval of the manuscript. We thank
   Gayle Petty and the Nutrition Evaluation laboratory at the Jean Mayer
   USDA Human Nutrition Research Center on Aging at Tufts University for
   analytical contributions.
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NR 52
TC 8
Z9 10
U1 1
U2 6
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2018
VL 65
IS 1
BP 293
EP 302
DI 10.3233/JAD-180366
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GQ0TG
UT WOS:000441331600024
PM 30040728
DA 2023-08-17
ER

PT J
AU Fei, YZ
   Wang, RR
   Lu, JC
   Peng, SH
   Yang, S
   Wang, YT
   Zheng, KX
   Li, R
   Lin, L
   Li, MQ
AF Fei, Yuzhe
   Wang, Ruiru
   Lu, Jiachun
   Peng, Songhao
   Yang, Song
   Wang, Yiting
   Zheng, Kaixuan
   Li, Ran
   Lin, Lin
   Li, Maoquan
TI Probiotic intervention benefits multiple neural behaviors in older
   adults with mild cognitive impairment
SO GERIATRIC NURSING
LA English
DT Article
DE Probiotic; MCI; Gut microbiome; Gut-brain axis; Neural behaviors
ID NEUROINFLAMMATION
AB Probiotic supplements were shown to improve cognitive function in Alzheimer's disease (AD) patients. However, it is still unclear whether this applies to older individuals with mild cognitive impairment (MCI). We aimed to explore the effects of probiotic supplementation on multiple neural behaviors in older adults with MCI. Forty-two MCI patients (age > 60 years) were randomly divided into two groups and consumed either probiotics (n=21) or placebo (n=21) for 12 weeks. Various scale scores, gut microbiota measures and serological indicators were recorded pre-and posttreatment. After 12 weeks of intervention, cognitive function and sleep quality were improved in the probiotic group compared with those in the control group, and the underlying mechanisms were associated with changes in the intestinal microbiota. In conclusion, our study demonstrated that probiotic treatment enhanced cognitive function and sleep quality in older MCI patients, thus providing important insights into the clinical prevention and treatment of MCI. & COPY; 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
C1 [Fei, Yuzhe; Wang, Ruiru; Yang, Song; Wang, Yiting; Li, Ran; Li, Maoquan] Chengdu Med Coll, Sch Publ Hlth, Chengdu, Sichuan, Peoples R China.
   [Lin, Lin; Li, Maoquan] Sichuan Collaborat Innovat Ctr Elderly Care & Hlth, Chengdu, Sichuan, Peoples R China.
   [Zheng, Kaixuan; Li, Maoquan] Chengdu Qingbaijiang Dist Tradit Chinese Med Hosp, Chengdu, Sichuan, Peoples R China.
   [Lin, Lin] Geriatr Hlth Acad, Chengdu Med Coll, Chengdu, Sichuan, Peoples R China.
   [Lu, Jiachun; Peng, Songhao; Lin, Lin] Chengdu Eighth Peoples Hosp, Chengdu, Sichuan, Peoples R China.
C3 Chengdu Medical College; Chengdu Medical College
RP Li, MQ (corresponding author), Chengdu Med Coll, Sch Publ Hlth, Chengdu, Sichuan, Peoples R China.; Lin, L; Li, MQ (corresponding author), Sichuan Collaborat Innovat Ctr Elderly Care & Hlth, Chengdu, Sichuan, Peoples R China.; Li, MQ (corresponding author), Chengdu Qingbaijiang Dist Tradit Chinese Med Hosp, Chengdu, Sichuan, Peoples R China.; Lin, L (corresponding author), Geriatr Hlth Acad, Chengdu Med Coll, Chengdu, Sichuan, Peoples R China.; Lin, L (corresponding author), Chengdu Eighth Peoples Hosp, Chengdu, Sichuan, Peoples R China.
EM 617866353@qq.com; limquan@cmc.edu.cn
FU Soft Science of the Sichuan Provincial Science and Technology Department
   [18Z081]; Sichuan Traditional Chinese Medicine Administration
   [2018KF016]; Sichuan Health Services Subsidy Project [304946]; Sichuan
   Social Science Key Research Base - Research Center for Aging Cause and
   Industrial Development [XJLL2022018]; Sichuan Philosophy and Social
   Sciences Key Research Base - China Panxi Health Care Industry Research
   Center [PXKY-YB-202218]
FX This study was supported by the Soft Science of the Sichuan Provincial
   Science and Technology Department (No. 18Z081) , the Sichuan Traditional
   Chinese Medicine Administration (No. 2018KF016) , the Sichuan Health
   Services Subsidy Project (No. 304946) , the Sichuan Social Science Key
   Research Base - Research Center for Aging Cause and Industrial
   Development (No. XJLL2022018) , and the Sichuan Philosophy and Social
   Sciences Key Research Base - China Panxi Health Care Industry Research
   Center (No. PXKY-YB-202218) .
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NR 48
TC 0
Z9 0
U1 3
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4572
EI 1528-3984
J9 GERIATR NURS
JI Geriatr. Nurs.
PD MAY-JUN
PY 2023
VL 51
BP 167
EP 175
DI 10.1016/j.gerinurse.2023.03.006
EA MAR 2023
PG 9
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA L6IM2
UT WOS:001024279600001
PM 36990042
OA hybrid
DA 2023-08-17
ER

PT J
AU Wu, YJ
   Xu, HY
   Sui, X
   Zeng, T
   Leng, X
   Li, YW
   Li, F
AF Wu, Yuejin
   Xu, Haiyan
   Sui, Xin
   Zeng, Ting
   Leng, Xin
   Li, Yuewei
   Li, Feng
TI Effects of group reminiscence interventions on depressive symptoms and
   life satisfaction in older adults with intact cognition and mild
   cognitive impairment: A systematic review
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Review
DE Reminiscence interventions; Life review; Group intervention; Dementia;
   Depression; Life satisfaction
ID QUALITY-OF-LIFE; SELF-ESTEEM; STRUCTURED REMINISCENCE; DECREASE
   DEPRESSION; THERAPY; LONELINESS; PROGRAM; PEOPLE; CARE
AB Objective: Reminiscence interventions have been extensively used to improve the psychological health of people with dementia. However, there is uncertainty about the effectiveness of group reminiscence interventions for older adults with intact cognition and mild cognitive impairment. Based on the large number of older adults and strained health care resources in China, we conducted a systematic review of the evidence on the effectiveness of group reminiscence interventions for older adults with intact cognition or mild cognitive impairment.Materials and methods: Five English databases were searched from inception to 21 August 2022. The quality of the included articles was assessed by using the Cochrane Risk of Bias Scale or Criteria (2020) and the Australian Evidence-Based Health Care Centre (2020). Data related to study and intervention characteristics were extracted.Results: Twenty-four articles were included, of which eight were quasiexperimental studies and sixteen were randomized controlled studies. The overall study quality was high, but most studies did not blind the participants. Group reminiscence interventions were beneficial in improving depressive symptoms and life satisfaction in older adults with intact cognition or mild cognitive impairment, but no valid conclusions could be drawn about the effect on quality of life.Conclusions: Group reminiscence interventions are an effective type of psychological intervention to improve the psychological health of older people. In addition, group reminiscence interventions are simple and easy to implement and can be considered a routine care activity to meet the spiritual needs of cognitively intact and mildly cognitively impaired older people.
C1 [Wu, Yuejin; Xu, Haiyan; Sui, Xin; Zeng, Ting; Leng, Xin; Li, Yuewei; Li, Feng] Jilin Univ, Sch Nursing, Changchun, Peoples R China.
C3 Jilin University
RP Li, F (corresponding author), Jilin Univ, Sch Nursing, Changchun, Peoples R China.
EM fli@jlu.edu.cn
OI Li, Feng/0000-0001-7423-8730
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NR 68
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD NOV
PY 2023
VL 114
AR 105103
DI 10.1016/j.archger.2023.105103
EA JUN 2023
PG 18
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA L9CJ6
UT WOS:001026167800001
PM 37354738
OA hybrid
DA 2023-08-17
ER

PT J
AU Zhu, SZ
   Sui, YX
   Shen, Y
   Zhu, Y
   Ali, N
   Guo, C
   Wang, T
AF Zhu, Shizhe
   Sui, Youxin
   Shen, Ying
   Zhu, Yi
   Ali, Nawab
   Guo, Chuan
   Wang, Tong
TI Effects of Virtual Reality Intervention on Cognition and Motor Function
   in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic
   Review and Meta-Analysis
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE meta-analysis; cognition; motor; virtual reality; mild cognitive
   impairment; dementia
ID ALZHEIMERS-DISEASE; ASSESSMENT BATTERY; BALANCE; DIAGNOSIS; MOBILITY;
   RISK; RELIABILITY; MANAGEMENT; SCALE; TOOL
AB Background: Virtual reality (VR) intervention is an innovative and efficient rehabilitative tool for patients affected by stroke, Parkinson's disease, and other neurological disorders. This meta-analysis aims to evaluate the effects of VR intervention on cognition and motor function in older adults with mild cognitive impairment or dementia.
   Methods: Seven databases were systematically searched for relevant articles published from inception to April 2020. Randomized controlled trials examining VR intervention in adults with mild cognitive impairment or dementia aged >60 years were included. The primary outcome of the study was cognitive function, including overall cognition, global cognition, attention, executive function, memory, and visuospatial ability. The secondary outcome was motor function, consisting of overall motor function, balance, and gait. A subgroup analysis was also performed based on study characteristics to identify the potential factors for heterogeneity.
   Results: Eleven studies including 359 participants were included for final analysis. Primary analysis showed a significant moderate positive effect size (ES) of VR on overall cognition (g = 0.45; 95% confidence interval (CI) = 0.31-0.59; P < 0.001), attention/execution (g = 0.49; 95% CI = 0.26-0.72; P < 0.001), memory (g = 0.57; 95% CI = 0.29-0.85; P < 0.001), and global cognition (g = 0.32; 95% CI = 0.06-0.58; P = 0.02). Secondary analysis showed a significant small positive ES on overall motor function (g = 0.28; 95% CI = 0.05-0.51; P = 0.018). The ES on balance (g = 0.43; 95% CI = 0.06-0.80; P = 0.02) was significant and moderate. The ES on visuospatial ability and gait was not significant. In the subgroup analysis, heterogeneity was detected in type of immersion and population diagnosis.
   Conclusions: VR intervention is a beneficial non-pharmacological approach to improve cognitive and motor function in older adults with mild cognitive impairment or dementia, especially in attention/execution, memory, global cognition, and balance. VR intervention does not show superiority on visuospatial ability and gait performance.
C1 [Zhu, Shizhe; Sui, Youxin; Shen, Ying; Zhu, Yi; Ali, Nawab; Guo, Chuan; Wang, Tong] Nanjing Med Univ, Dept Rehabil, Affiliated Hosp 1, Nanjing, Peoples R China.
   [Zhu, Shizhe; Sui, Youxin; Wang, Tong] Nanjing Med Univ, Sch Rehabil Med, Nanjing, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University
RP Guo, C; Wang, T (corresponding author), Nanjing Med Univ, Dept Rehabil, Affiliated Hosp 1, Nanjing, Peoples R China.; Wang, T (corresponding author), Nanjing Med Univ, Sch Rehabil Med, Nanjing, Peoples R China.
EM guochuanrehab@126.com; wangtong60621@163.com
OI Sui, Youxin/0000-0002-5010-0320; Guo, Chuan/0000-0001-9181-4293
FU National Key R&D Program of China [2018YFC2001600, 2018YFC2001603]
FX This work was supported by the National Key R&D Program of China [Grant
   No.: 2018YFC2001600 and 2018YFC2001603].
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NR 70
TC 20
Z9 21
U1 10
U2 58
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD MAY 5
PY 2021
VL 13
AR 586999
DI 10.3389/fnagi.2021.586999
PG 15
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA SE7XI
UT WOS:000652282500001
PM 34025384
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Amofa, PA
   DeFeis, B
   De Wit, L
   O'Shea, D
   Mejia, A
   Chandler, M
   Locke, DEC
   Fields, J
   Phatak, V
   Dean, PM
   Crook, J
   Smith, G
AF Amofa, Priscilla A., Sr.
   DeFeis, Brittany
   De Wit, Liselotte
   O'Shea, Deirdre
   Mejia, Andrea
   Chandler, Melanie
   Locke, Dona E. C.
   Fields, Julie
   Phatak, Vaishali
   Dean, Pamela M.
   Crook, Julia
   Smith, Glenn
TI Functional ability is associated with higher adherence to behavioral
   interventions in mild cognitive impairment
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Article
DE MCI; cognitive intervention; multimodal behavioral intervention;
   post-intervention adherence; aging
ID OLDER-ADULTS; PHYSICAL-ACTIVITY; SHORT-VERSION; PROGRAM; DISABILITY;
   DECLINE; PEOPLE; EDUCATION; DISEASE; IMPACT
AB Objective: Behavioral interventions during early memory decline hold promise in delaying the development of dementia. In the present study, participants in a multimodal behavioral intervention study were assessed for post-intervention adherence and predictors of adherence. Methods: Participants (N?=?272, mean age?=?75.04???7.54) diagnosed with amnestic Mild Cognitive Impairment (aMCI) were assigned to intervention groups receiving four out of five behavioral intervention components, including yoga, memory compensation training, computerized cognitive training, support groups, and/or wellness education. Length of the intervention was 10?days, 4?h per day, with post-intervention follow-up at 6, 12, and 18?months. Results: Two-hundred and thirty-seven participants completed the 6-month post-intervention follow-up measures, 228 participants completed the 12-month measures, and 218 participants completed the 18-month measures. Participants fully adhered to a mean of 2 out of the 4 taught intervention components. Eighty-nine percent of participants were at least partially adherent to one or more taught intervention components at 6-, 12-, and 18-month post-intervention follow-up. Physical activity was the most adhered to intervention while group support was the least adhered to intervention across all three follow-up time-points. Higher educational level, higher baseline depressive symptoms, higher baseline global cognitive functioning, and better baseline and concurrent functional abilities were associated post-intervention adherence. Conclusion: Changes in functional abilities are associated with disease progression among persons with aMCI. In the present study, individuals with aMCI who have higher education, higher depressive symptoms, and better baseline functioning abilities are more likely to adhere to behavioral intervention components over time. Post-intervention adherence also associates with concurrent daily function.
C1 [Amofa, Priscilla A., Sr.; DeFeis, Brittany; De Wit, Liselotte; O'Shea, Deirdre; Mejia, Andrea; Smith, Glenn] Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
   [Chandler, Melanie] Mayo Clin Florida, Dept Psychiat & Psychol, Jacksonville, FL USA.
   [Locke, Dona E. C.] Mayo Clin Arizona, Dept Psychiat & Psychol, Scottsdale, AZ USA.
   [Fields, Julie; Smith, Glenn] Mayo Clin Minnesota, Dept Psychiat & Psychol, Rochester, MN USA.
   [Phatak, Vaishali] Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE USA.
   [Dean, Pamela M.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Crook, Julia] Mayo Clin Florida, Div Biomed Stat & Informat, Jacksonville, FL USA.
C3 State University System of Florida; University of Florida; Mayo Clinic;
   Mayo Clinic; Mayo Clinic Phoenix; University of Nebraska System;
   University of Nebraska Medical Center; University of Washington;
   University of Washington Seattle; Mayo Clinic
RP Smith, G (corresponding author), Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
EM glennsmith@phhp.ufl.edu
RI OShea, Deirdre/AAA-5141-2022
OI DeFeis, Brittany/0000-0003-2763-7098
FU Patient-Centered Outcomes Research Institute (PCORI) Award
   [CER-1306-01897]
FX Research reported in this manuscript was partially funded through The
   Patient-Centered Outcomes Research Institute (PCORI) Award
   (CER-1306-01897).
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NR 43
TC 14
Z9 15
U1 3
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PD JUL 3
PY 2020
VL 34
IS 5
BP 937
EP 955
DI 10.1080/13854046.2019.1672792
EA OCT 2019
PG 19
WC Psychology, Clinical; Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA ME2MY
UT WOS:000490023300001
PM 31608773
OA hybrid, Green Accepted
DA 2023-08-17
ER

PT J
AU Zhou, XL
   Wang, LN
   Wang, J
   Shen, XH
   Zhao, X
AF Zhou, Xiang-Lian
   Wang, Li-Na
   Wang, Jie
   Shen, Xin-Hua
   Zhao, Xia
TI Effects of exercise interventions for specific cognitive domains in old
   adults with mild cognitive impairment A protocol of subgroup
   meta-analysis of randomized controlled trials
SO MEDICINE
LA English
DT Review
DE aged; cognitive; exercise; meta-analysis; mild cognitive impairment
ID AEROBIC EXERCISE; TAI CHI; IMPLEMENTATION SUBCOMMITTEE; GUIDELINE
   DEVELOPMENT; ALZHEIMERS-DISEASE; AMERICAN ACADEMY; DISSEMINATION;
   NEUROGENESIS; DEMENTIA; QUALITY
AB Background: Mild cognitive impairment (MCI) is the clinical prognosis that leads to dementia. Early intervention of MCI is critical to protect against dementia. Exercise intervention has gained popularity for the management of MCI. Most current studies have focused only on improvements made by exercise interventions on the global/general cognitive function and/or a specific cognitive function. However, no studies have been performed on a subgroup analysis of the effects of exercise interventions on different cognitive domains of the elderly with MCI. The exploration of this issue will help to clarify the influence and through a preliminary analysis identify the level of influence of exercise interventions on particular cognitive domains, and it will provide the theoretical framework for the construction of precise exercise intervention strategies for MCI patients. Methods: A systematic review of electronic databases (MEDLINE, Embase, The Cochrane Library, Web of Science, CNKI, the Wan Fang Database, and CBM), supplemented by expert contact, reference and citation checking, and gray literature searches have been conducted. There is no restriction on language or publication status. Cochrane Handbook for Systematic Reviews of Interventions and add another 3 items according to PEDpro, including "the type of statistical analyses used (true intention-to-treat vs other)," "eligibility criteria," and "baseline comparability," are used to assess the risk of bias. Primary outcomes of interest are standardized measurements of executive functions, memory, language, processing speed, and attention. If possible, we conduct a meta-analysis to synthesize the evidence for each outcome. Results: This study will provide a high-quality synthesis of current evidence of exercise for MCI patients. Conclusion: The conclusion of this systematic review will provide evidence to judge whether exercise is an effective intervention for patient with MCI and preliminary ranking of the effects of exercise on specific cognitive domains. Prospero registration number: CRD42018093902
C1 [Zhou, Xiang-Lian; Wang, Li-Na; Wang, Jie] Huzhou Univ, Sch Nursing, Med Coll, Huzhou 313000, Zhejiang, Peoples R China.
   [Shen, Xin-Hua] Naval Med Univ, Changhai Hosp, Dept Gynecol Tradit Chinese Med, Shanghai, Peoples R China.
   [Zhao, Xia] Huzhou Third Peoples Hosp, Dept Psychosomat Dis, Huzhou, Zhejiang, Peoples R China.
C3 Huzhou University; Naval Medical University
RP Wang, LN (corresponding author), Huzhou Univ, Sch Nursing, Med Coll, Huzhou 313000, Zhejiang, Peoples R China.
EM aring2000@163.com
FU National Natural Science Foundation [71704053]; China Scholarship
   Council [201908330251]; Zhejiang Province Natural Science [LQ17G030002]
FX This work was supported by the National Natural Science Foundation
   (NO.71704053);r China Scholarship Council (NO.201908330251); and
   Zhejiang Province Natural Sciencer Foundation (NO. LQ17G030002). Thank
   statistician Xueqiang Wang for providing statistical guidance to this
   study.
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NR 56
TC 14
Z9 15
U1 4
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 31
PY 2020
VL 99
IS 31
DI 10.1097/MD.0000000000020105
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA NE6EZ
UT WOS:000562693800003
PM 32756073
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Lam, LCW
   Chan, WC
   Leung, T
   Fung, AWT
   Leung, EMF
AF Lam, Linda Chiu-wa
   Chan, Wai Chi
   Leung, Tony
   Fung, Ada Wai-tung
   Leung, Edward Man-fuk
TI Would Older Adults with Mild Cognitive Impairment Adhere to and Benefit
   from a Structured Lifestyle Activity Intervention to Enhance Cognition?:
   A Cluster Randomized Controlled Trial
SO PLOS ONE
LA English
DT Article
ID PHYSICAL-ACTIVITY; ALZHEIMERS-DISEASE; DEMENTIA; EXERCISE; VALIDATION;
   MEMORY; PREVALENCE; HEALTH; RISK
AB Background
   Epidemiologic evidence suggests that cognitive and physical activities are associated with better cognition in late life. The present study was conducted to examine the possible benefits of four structured lifestyle activity interventions and compare their effectiveness in optimizing cognition for older adults with mild cognitive impairment (MCI).
   Method and Findings
   This was a 12-month cluster randomized controlled trial. 555 community-dwelling Chinese older adults with MCI (295 with multiple-domain deficits (mdMCI), 260 with single-domain deficit (sdMCI)) were recruited. Participants were randomized into physical exercise (P), cognitive activity (C), integrated cognitive and physical exercise (CP), and social activity (S, active control) groups. Interventions comprised of one-hour structured activities three times per week. Primary outcome was Clinical Dementia Rating sum of boxes (CDR-SOB) scores. Secondary outcomes included Chinese versions of Alzheimer's Disease Assessment Scale Cognitive subscale (ADAS-Cog), delayed recall, Mini-Mental State Examination, Category Verbal Fluency Test (CVFT) and Disability Assessment for Dementia - Instrumental Activities of Daily Living (DAD-IADL). Percentage adherence to programs and factors affecting adherence were also examined. At 12th month, 423 (76.2%) completed final assessment. There was no change in CDR-SOB and DAD-IADL scores across time and intervention groups. Multilevel normal model and linear link function showed improvement in ADAS-Cog, delayed recall and CVFT with time (p<0.05). Post-hoc subgroup analyses showed that the CP group, compared with other intervention groups, had more significant improvements of ADAS-Cog, delayed recall and CVFT performance with sdMCI participants (p<0.05). Overall adherence rate was 73.3%. Improvements in ADAS-Cog and delayed recall scores were associated with adherence after controlling for age, education, and intervention groups (univariate analyses).
   Conclusions
   Structured lifestyle activity interventions were not associated with changes in everyday functioning, albeit with some improvements in cognitive scores across time. Higher adherence was associated with greater improvement in cognitive scores. Factors to enhance adherence should be specially considered in the design of psychosocial interventions for older adults with cognitive decline.
C1 [Lam, Linda Chiu-wa; Leung, Tony; Fung, Ada Wai-tung] Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
   [Chan, Wai Chi] Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
   [Leung, Edward Man-fuk] United Christian Hosp, Dept Med & Geriatr, Hong Kong, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; University of Hong Kong; United
   Christian Hospital
RP Lam, LCW (corresponding author), Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China.
EM cwlam@cuhk.edu.hk
RI Chan, Wai Chi/J-6947-2012; FUNG, Ada Wai-Tung/K-7383-2019
OI FUNG, Ada Wai-Tung/0000-0001-7439-3503
FU Simon KY Lee Fund for the Elderly in Hong Kong
FX This project was funded by a donation from the Simon KY Lee Fund for the
   Elderly in Hong Kong. The funder had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 30
TC 92
Z9 95
U1 1
U2 42
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 31
PY 2015
VL 10
IS 3
AR e0118173
DI 10.1371/journal.pone.0118173
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CE8IF
UT WOS:000352084800002
PM 25826620
OA gold, Green Published, Green Submitted
DA 2023-08-17
ER

PT J
AU Smith, JC
   Nielson, KA
   Antuono, P
   Lyons, JA
   Hanson, RJ
   Butts, AM
   Hantke, NC
   Verber, MD
AF Smith, J. Carson
   Nielson, Kristy A.
   Antuono, Piero
   Lyons, Jeri-Annette
   Hanson, Ryan J.
   Butts, Alissa M.
   Hantke, Nathan C.
   Verber, Matthew D.
TI Semantic Memory Functional MRI and Cognitive Function after Exercise
   Intervention in Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Alzheimer's disease; dementia; exercise; magnetic resonance imaging;
   memory; non-pharmacologic treatment; physical activity; physical fitness
ID ALZHEIMERS ASSOCIATION WORKGROUPS; PHYSICAL-ACTIVITY; OLDER-ADULTS;
   DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; AMYLOID LOAD; ACTIVATION;
   DISEASE; RISK; DEMENTIA
AB Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants and 18 cognitively intact controls, similar in sex, age, education, genetic risk, and medication use, volunteered for a 12-week exercise intervention consisting of supervised treadmill walking at a moderate intensity. Both MCI and control participants significantly increased their cardiorespiratory fitness by approximately 10% on a treadmill exercise test. Before and after the exercise intervention, participants completed an fMRI famous name discrimination task and a neuropsychological battery, Performance on Trial 1 of a list-learning task significantly improved in the MCI participants. Eleven brain regions activated during the semantic memory task showed a significant decrease in activation intensity following the intervention that was similar between groups (p-values ranged 0.048 to 0.0001). These findings suggest exercise may improve neural efficiency during semantic memory retrieval in MCI and cognitively intact older adults, and may lead to improvement in cognitive function. Clinical trials are needed to determine if exercise is effective to delay conversion to AD.
C1 [Smith, J. Carson; Verber, Matthew D.] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA.
   [Nielson, Kristy A.; Butts, Alissa M.; Hantke, Nathan C.] Marquette Univ, Dept Psychol, Milwaukee, WI 53233 USA.
   [Smith, J. Carson; Nielson, Kristy A.; Antuono, Piero] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA.
   [Lyons, Jeri-Annette] Univ Wisconsin, Dept Biomed Sci, Milwaukee, WI 53201 USA.
   [Hanson, Ryan J.] Univ Wisconsin, Dept Psychol, Milwaukee, WI 53201 USA.
C3 University System of Maryland; University of Maryland College Park;
   Marquette University; Medical College of Wisconsin; University of
   Wisconsin System; University of Wisconsin Milwaukee; University of
   Wisconsin System; University of Wisconsin Milwaukee
RP Smith, JC (corresponding author), Univ Maryland, Dept Kinesiol, 2351 SPH Bldg, College Pk, MD 20742 USA.
EM carson@umd.edu
RI Smith, J. Carson/G-6404-2013
OI Smith, J. Carson/0000-0001-6142-0920; Nielson,
   Kristy/0000-0001-8977-3138
FU Graduate School Research Growth Initiative at the University of
   Wisconsin-Milwaukee; Clinical and Translational Science Award (CTSA)
   program of the National Center for Research Resources, National
   Institutes of Health [UL1RR031973]
FX We thank all of the participants for their time and effort, and
   gratefully acknowledge the cooperation and collaboration of the
   community and commercial fitness centers where the participants
   exercised. We also appreciate the dedication of our excellent research
   staff, including study coordinator Karen Outzen; exercise physiologists
   and personal fitness trainers Andrew Mattes, Karlee Sweere, Lynn
   Wheeler, Rebecca Ohmen, Bethany Brooks, Ed Possing, Bradley Kohl, David
   Cornell, Jacqueline Geib, David Johnson, Rong Tang, and William Massey;
   and the nurses and MRI technicians at the CTSI Translational Research
   Unit at the Medical College of Wisconsin. Additionally, we acknowledge
   Kevin Regner, M. D., Jeanne Palmer, M. D., Elizabeth Cogbill, M. D.,
   Tinoy Kizhakekuttu, M. D., and Kodlipet Dharmashankar, M. D., for their
   collegial provision of medical coverage during exercise and MRI test
   sessions; Danielle Kauffman for help with data processing; and Erin
   Browning for her technical expertise and help in MRI data collection.
   Technical support for APOE genotyping was provided by Stacy Meyer and
   Erin Koester. This work was supported by a grant from the Graduate
   School Research Growth Initiative at the University of
   Wisconsin-Milwaukee; and by the Clinical and Translational Science Award
   (CTSA) program of the National Center for Research Resources, National
   Institutes of Health [grant number UL1RR031973].
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NR 80
TC 95
Z9 102
U1 2
U2 59
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2013
VL 37
IS 1
BP 197
EP 215
DI 10.3233/JAD-130467
PG 19
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 206AJ
UT WOS:000323487300018
PM 23803298
OA Green Published, Green Accepted
DA 2023-08-17
ER

PT J
AU Quinn, C
   Toms, G
   Anderson, D
   Clare, L
AF Quinn, Catherine
   Toms, Gill
   Anderson, Daniel
   Clare, Linda
TI A Review of Self-Management Interventions for People With Dementia and
   Mild Cognitive Impairment
SO JOURNAL OF APPLIED GERONTOLOGY
LA English
DT Review
DE Alzheimer's disease; group intervention; psychosocial intervention;
   self-efficacy; self-care
ID EARLY-STAGE DEMENTIA; CHRONIC DISEASE; SIGNIFICANT OTHERS;
   CONTROLLED-TRIAL; HEALTH-STATUS; GROUP-THERAPY; SINGLE-BLIND; MEMORY
   CLUB; PROGRAM; CARE
AB Self-management offers a way of helping people with dementia or mild cognitive impairment (MCI) to play an active role in managing their condition. Barlow, Wright, Sheasby, Turner, and Hainsworth have defined self-management as the individual's ability to manage the symptoms, treatment, physical and psychosocial consequences and life style changes inherent in living with a chronic condition. Although commonly used in other chronic health conditions, there has been relatively little exploration of the role of self-management in dementia or MCI. This review aimed to identify group-based psychosocial interventions for people with dementia or MCI that incorporate significant elements of self-management. Fifteen interventions were included in the review: 12 for people with dementia and 3 for participants with MCI. In both the dementia and MCI interventions, the most commonly included self-management components were information, communication, and social support, and skills training. The review findings indicate that components of self-management have been incorporated into group-based interventions for people with dementia and MCI. Further studies are needed to address the methodological limitations of the included studies and to determine the effectiveness of self-management interventions with these populations.
C1 [Quinn, Catherine; Toms, Gill; Clare, Linda] Bangor Univ, Bangor LL57 2AS, Gwynedd, Wales.
   [Anderson, Daniel] Retreat, York, N Yorkshire, England.
C3 Bangor University
RP Quinn, C (corresponding author), Bangor Univ, Sch Psychol, Bangor LL57 2AS, Gwynedd, Wales.
EM catherine.quinn@bangor.ac.uk
RI Quinn, Catherine/H-6498-2019; Anderson, Daniel/AAD-6587-2020
OI Quinn, Catherine/0000-0001-9553-853X; Anderson,
   Daniel/0000-0003-2915-5367; Clare, Linda/0000-0003-3989-5318
FU National Institute for Social Care and Health Research (NISCHR)
   [RFS-12-35]; Health and Care Research Wales [RFS-12-35] Funding Source:
   researchfish
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by the National Institute for Social Care and Health Research
   (NISCHR) (Grant RFS-12-35).
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NR 79
TC 51
Z9 53
U1 2
U2 34
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0733-4648
EI 1552-4523
J9 J APPL GERONTOL
JI J. Appl. Gerontol.
PD NOV
PY 2016
VL 35
IS 11
BP 1154
EP 1188
DI 10.1177/0733464814566852
PG 35
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA DZ6GP
UT WOS:000385960000003
PM 25608870
DA 2023-08-17
ER

PT J
AU Teixeira, CVL
   Gobbi, LTB
   Corazza, DI
   Stella, F
   Costa, JLR
   Gobbi, S
AF Ligo Teixeira, Camila Vieira
   Bucken Gobbi, Lilian Teresa
   Corazza, Danilla Icassatti
   Stella, Florindo
   Riani Costa, Jose Luiz
   Gobbi, Sebastiao
TI Non-pharmacological interventions on cognitive functions in older people
   with mild cognitive impairment (MCI)
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Mild cognitive impairment; Cognitive functions; Physical activity;
   Cognitive intervention; Systemic review
ID ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; REHABILITATION PROGRAM; DEMENTIA;
   MEMORY; EXERCISE; ADULTS; HEALTH; IMPROVEMENT; CONVERSION
AB Mild cognitive impairment (MCI) can be a stage of pre-dementia. There is no consensus about pharmacological treatment for this population, so it is important to structure non-pharmacological interventions for increasing their cognitive reserve. We intended to analyze the effects of non-pharmacological interventions in the cognitive functions in older people with MC, in form of a systemic review. Data sources were the Web of Science, Biological Abstracts, Medline, Pub Med, EBSCHost, Scirus and Google Scholar. All studies were longitudinal trials, with MCI sample, aged > 60 years, community-dwelling, and having cognitive functions as dependent variable. Seven studies, from 91 previously selected ones, were identified according to the inclusion criteria. Six studies used cognitive intervention, improving memory and one study used physical activity as intervention, improving executive functions. The results show evidence that physical activity and cognitive exercise may improve memory and executive functions in older people with MCI. But yet, more controlled studies are needed to establish a protocol of recommendations regarding the systemization of exercise, necessary to produce benefits in the cognitive functioning in older people with MCI. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Ligo Teixeira, Camila Vieira; Bucken Gobbi, Lilian Teresa; Corazza, Danilla Icassatti; Stella, Florindo; Riani Costa, Jose Luiz; Gobbi, Sebastiao] Univ Estadual Paulista, Inst Biosci, Dept Phys Educ, Phys Act & Aging Lab LAFE, BR-13506900 Rio Claro, SP, Brazil.
   [Stella, Florindo] Univ Estadual Campinas, UNICAMP, Clin Geriatr Psychiat, BR-13083887 Campinas, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual de Campinas
RP Teixeira, CVL (corresponding author), Univ Estadual Paulista, Inst Biosci, Dept Phys Educ, Phys Act & Aging Lab LAFE, 1515 24A Ave, BR-13506900 Rio Claro, SP, Brazil.
EM cateixeira98@yahoo.com.br
RI Gobbi, Lilian T B/C-9879-2010
OI Gobbi, Lilian T B/0000-0003-3984-3403
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
FX Financial support from the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) is acknowledged.
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NR 48
TC 83
Z9 86
U1 1
U2 39
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD JAN-FEB
PY 2012
VL 54
IS 1
BP 175
EP 180
DI 10.1016/j.archger.2011.02.014
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 841VB
UT WOS:000296542200031
PM 21397960
DA 2023-08-17
ER

PT J
AU Belleville, S
   Gilbert, B
   Mellah, S
   Fontaine, S
   Blanchet, S
   Gauthier, S
AF Belleville, S
   Gilbert, B
   Mellah, S
   Fontaine, S
   Blanchet, S
   Gauthier, S
TI Cognitive improvement and neural substrate of memory intervention in
   persons with mild cognitive impairment
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Meeting Abstract
C1 Inst Univ Geriatr Montreal, Res Ctr, Montreal, PQ, Canada.
   IRDPQ, Quebec City, PQ, Canada.
   McGill Ctr Studies Aging, Montreal, PQ, Canada.
C3 Universite de Montreal; Laval University; McGill University
RI Blanchet, Simon/AAA-5871-2019
OI Blanchet, Simon/0000-0002-3843-589X
NR 0
TC 0
Z9 0
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 40 WEST 20TH ST, NEW YORK, NY 10011-4211 USA
SN 1041-6102
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PY 2005
VL 17
SU 2
BP 70
EP 70
PG 1
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 984RQ
UT WOS:000233322400128
DA 2023-08-17
ER

PT J
AU Zhou, XL
   Wang, LN
   Wang, J
   Shen, XH
   Zhao, X
AF Zhou, Xiang-Lian
   Wang, Li-Na
   Wang, Jie
   Shen, Xin-Hua
   Zhao, Xia
TI Effects of exercise interventions for specific cognitive domains in old
   adults with mild cognitive impairment A protocol of subgroup
   meta-analysis of randomized controlled trials
SO MEDICINE
LA English
DT Review
DE aged; cognitive; exercise; meta-analysis; mild cognitive impairment
ID AEROBIC EXERCISE; PERFORMANCE; DEMENTIA
AB Background: Mild cognitive impairment (MCI) is the clinical prognosis that leads to dementia. Early intervention of MCI is critical to protect against dementia. Exercise intervention has gained popularity for the management of MCI. Most current studies have focused only on improvements made by exercise interventions on the global/general cognitive function and/or a specific cognitive function. However, no studies have been performed on a subgroup analysis of the effects of exercise interventions on different cognitive domains of the elderly with MCI. The exploration of this issue will help to clarify the influence and through a preliminary analysis identify the level of influence of exercise interventions on particular cognitive domains, and it will provide the theoretical framework for the construction of precise exercise intervention strategies for MCI patients.
   Methods: A systematic review of electronic databases (MEDLINE, Embase, The Cochrane Library, Web of Science, CNKI, the Wan Fang Database, and CBM), supplemented by expert contact, reference and citation checking, and gray literature searches have been conducted. There is no restriction on language or publication status. Cochrane Handbook for Systematic Reviews of Interventions and add another 3 items according to PEDpro, including "the type of statistical analyses used (true intention-to-treat vs other)," "eligibility criteria," and "baseline comparability," are used to assess the risk of bias. Primary outcomes of interest are standardized measurements of executive functions, memory, language, processing speed, and attention. If possible, we conduct a meta-analysis to synthesize the evidence for each outcome.
   Results: This study will provide a high-quality synthesis of current evidence of exercise for MCI patients.
   Conclusion: The conclusion of this systematic review will provide evidence to judge whether exercise is an effective intervention for patient with MCI and preliminary ranking of the effects of exercise on specific cognitive domains.
C1 [Zhou, Xiang-Lian; Wang, Li-Na; Wang, Jie; Zhao, Xia] Huzhou Univ, Med Coll, Sch Nursing, Huzhou 313000, Zhejiang, Peoples R China.
   [Shen, Xin-Hua] Huzhou Third Peoples Hosp, Dept Psychosomat Dis, Huzhou, Zhejiang, Peoples R China.
C3 Huzhou University
RP Wang, LN (corresponding author), Huzhou Univ, Med Coll, Sch Nursing, Huzhou 313000, Zhejiang, Peoples R China.
EM aring2000@163.com
FU National Natural Science Foundation of China [7170 4053]; Zhejiang
   Provincial Natural Science Foundation of China [LQ17G030002]
FX This work was supported by the National Natural Science Foundation of
   China (no: 7170 4053), and Zhejiang Provincial Natural Science
   Foundation of China (no: LQ17G030002).
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NR 32
TC 4
Z9 4
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2018
VL 97
IS 48
AR e13244
DI 10.1097/MD.0000000000013244
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HD4AE
UT WOS:000452467000029
PM 30508909
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Shin, J
   Jang, J
   Afaya, A
AF Shin, Jinhee
   Jang, Jiyoon
   Afaya, Agani
TI Effectiveness of eHealth interventions targeted to improve medication
   adherence among older adults with mild cognitive impairment: a protocol
   for a systematic review and meta-analysis
SO BMJ OPEN
LA English
DT Review
DE Dementia; Adult psychiatry; Delirium & cognitive disorders
ID PROSPECTIVE MEMORY; MANAGEMENT; COMMUNITY; RISK
AB IntroductionMedication adherence is a vital component of successful healthcare, yet poor adherence exists, especially in older adults with mild cognitive impairment. Therefore, this study seeks to conduct a systematic review of eHealth-based interventions aimed at improving medication adherence among older adults with mild cognitive impairment.Methods and analysisAn open electronic database search will be conducted in PubMed, CINAHL, PsycINFO, EMBASE and Cochrane library to identify potential studies till 2022. Two authors will independently screen the titles and abstracts, after which studies that will be eligible for full-text review will be independently assessed by two reviewers for inclusion. Studies will be selected if they evaluate eHealth interventions aiming to improve medication adherence among older adults with mild cognitive impairment. Data will be analysed by using the Comprehensive Meta-Analysis software V.3 and Review Manager (RevMan) software V.5. The authors will separately analyse each outcome measure, compute intervention effects and present them as relative risks with 95% CIs for dichotomous data. Continuous data will be presented as mean differences and standardised mean differences (if required) with 95% CIs. If substantive statistical heterogeneity is identified, we will consider the use of random-effects models that can be incorporated into the statistical analysis. We envisage that this review will adduce evidence on eHealth interventions that will improve medication adherence among older adults with mild cognitive impairment. The findings can also inform health professionals and other relevant stakeholders on current eHealth-based interventions that are used to improve medication adherence among older adults with mild cognitive impairment.Ethics and disseminationEthical approval is not required for systematic reviews. Findings will be disseminated widely through peer-reviewed publication and at conferences.PROSPERO registration numberCRD42021268665.
C1 [Shin, Jinhee] Woosuk Univ, Coll Nursing, Jeollabuk Do, South Korea.
   [Jang, Jiyoon; Afaya, Agani] Yonsei Univ, MoIm Kim Nursing Res Inst, Coll Nursing, Seoul, South Korea.
   [Jang, Jiyoon] Yonsei Univ, Coll Nursing, Seoul, South Korea.
   [Jang, Jiyoon] Yonsei Univ, Brain Korea FOUR Project 21, Seoul, South Korea.
   [Afaya, Agani] Univ Hlth & Allied Sci, Sch Nursing & Midwifery, Dept Nursing, Ho, Ghana.
C3 Woosuk University; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System; Yonsei University
RP Afaya, A (corresponding author), Yonsei Univ, MoIm Kim Nursing Res Inst, Coll Nursing, Seoul, South Korea.; Afaya, A (corresponding author), Univ Hlth & Allied Sci, Sch Nursing & Midwifery, Dept Nursing, Ho, Ghana.
OI Shin, Jinhee/0000-0001-5715-3815; Afaya, Agani/0000-0002-7918-2999
FU Information Specialist at Yonsei University, Seoul, South Korea
FX We acknowledge the help and support of the Information Specialist at
   Yonsei University, Seoul, South Korea.
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NR 29
TC 0
Z9 0
U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD NOV
PY 2022
VL 12
IS 11
DI 10.1136/bmjopen-2021-060590
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6F0NO
UT WOS:000883767400031
PM 36323471
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Landry, GJ
   Liu-Ambrose, T
AF Landry, Glenn J.
   Liu-Ambrose, Teresa
TI Buying time: a rationale for examining the use of circadian rhythm and
   sleep interventions to delay progression of mild cognitive impairment to
   Alzheimer's disease
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE circadian; sleep; chronotherapy; bright light therapy; aging; mild
   cognitive impairment; Alzheimer's; dementia
ID PHASE RESPONSE CURVE; APOLIPOPROTEIN-E POLYMORPHISM; BRIGHT LIGHT
   THERAPY; RANDOMIZED-CONTROLLED-TRIAL; REST-ACTIVITY RHYTHM; HUMAN
   SUPRACHIASMATIC NUCLEUS; SEASONAL AFFECTIVE-DISORDER; GENOME-WIDE
   ASSOCIATION; NIGHT-SHIFT WORK; DAYTIME SLEEPINESS
AB As of 2010, the worldwide economic impact of dementia was estimated at $604 billion USD; and without discovery of a cure or effective interventions to delay disease progression, dementia's annual global economic impact is expected to surpass $1 trillion USD as early as 2030. Alzheimer's disease (AD) is the leading cause of dementia accounting for over 75% of all cases. Toxic accumulation of amyloid beta (A beta), either by overproduction or some clearance failure, is thought to be an underlying mechanism of the neuronal cell death characteristic of AD-though this amyloid hypothesis has been increasingly challenged in recent years. A compelling alternative hypothesis points to chronic neuroinflammation as a common root in late-life degenerative diseases including AD. Apolipoprotein-E (APOE) genotype is the strongest genetic risk factor for AD: APOE-epsilon 4 is proinflammatory and individuals with this genotype accumulate more A beta are at high risk of developing AD, and almost half of all AD patients have atleast one epsilon 4 allele. Recent studies suggest a bidirectional relationship exists between sleep and AD pathology. Sleep may play an important role in A beta clearance, and getting good quality sleep vs. poor quality sleep might reduce the AD risk associated with neuroinflammation and the epsilon 4 allele. Taken together, these findings are particularly important given the sleep disruptions commonly associated with AD and the increased burden disrupted sleep poses for AD caregivers. The current review aims to:(1) identify individuals at high risk for dementia who may benefit most from sleep interventions;(2) explore the role poor sleep quality plays in exacerbating AD type dementia;(3) examine the science of sleep interventions to date; and (4) provide a road map in pursuit of comprehensive sleep interventions, specifically targeted to promote cognitive function and delay progression of dementia.
C1 [Landry, Glenn J.; Liu-Ambrose, Teresa] Univ British Columbia, Fac Med, Aging Mobil & Cognit Neurosci Lab, Dept Phys Therapy, Vancouver, BC V6T 1Z3, Canada.
   [Landry, Glenn J.; Liu-Ambrose, Teresa] Univ British Columbia, Djavad Mowafaghian Ctr Brain Hlth, Vancouver, BC V6T 1Z3, Canada.
   [Liu-Ambrose, Teresa] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 1Z3, Canada.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia
RP Liu-Ambrose, T (corresponding author), Univ British Columbia, Fac Med, Aging Mobil & Cognit Neurosci Lab, Dept Phys Therapy, 212-2177 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
EM teresa.ambrose@ubc.ca
RI Liu-Ambrose, Teresa/W-2332-2019; Landry, Glenn J/L-2133-2015
OI Liu-Ambrose, Teresa/0000-0002-8297-5308; Landry, Glenn
   J/0000-0002-6946-3914
FU Jack Brown and Family Alzheimer Research Foundation
FX Funding for this work was provided to Teresa Liu-Ambrose by the Jack
   Brown and Family Alzheimer Research Foundation. Glenn J. Landry is a
   Canadian Institutes of Health Research Post-Doctoral Fellow. Teresa
   Liu-Ambrose is a Canada Research Chair Tier II in Physical Activity,
   Mobility, and Cognitive Neuroscience. We wish to thank Dr. Ralph
   Mistlberger and Dr. John Best for helpful discussions while preparing
   this review.
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NR 249
TC 60
Z9 62
U1 0
U2 38
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD DEC 8
PY 2014
VL 6
AR 325
DI 10.3389/fnagi.2014.00325
PG 21
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA AY9RY
UT WOS:000347889200001
PM 25538616
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Park, H
   Park, JH
   Na, HR
   Hiroyuki, S
   Kim, GM
   Jung, MK
   Kim, WK
   Park, KW
AF Park, Hyuntae
   Park, Jong Hwan
   Na, Hae Ri
   Hiroyuki, Shimada
   Kim, Gwon Min
   Jung, Mm Ki
   Kim, Woo Kyung
   Park, Kyung Won
TI Combined Intervention of Physical Activity, Aerobic Exercise, and
   Cognitive Exercise Intervention to Prevent Cognitive Decline for
   Patients with Mild Cognitive Impairment: A Randomized Controlled
   Clinical Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE dual-task; randomized controlled trial; dementia; older adults
ID ENERGY-EXPENDITURE; ALZHEIMER-DISEASE; OLDER-ADULTS; HEALTH;
   PERFORMANCE; PROGRESSION; VALIDATION; JAPANESE; OUTCOMES; RISK
AB This study aimed to investigate the association between a dual-task intervention program and cognitive and physical functions. In a randomized controlled trial, we enrolled 49 individuals with MCI. The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the MMSE and modified Alzheimer's disease Assessment Scale-Cognitive Subscale (ADAS-Cog), both at baseline and at 3 months follow-up. The program comprised physical activity and behavior modification, aerobic exercise, and a cognitive and exercise combined intervention program. Analysis of the subjects for group-time interactions revealed that the exercise group exhibited a significantly improved ADAS-Cog, working memory, and executive function. Total physical activity levels were associated with improvements in working memory function and the modified ADAS-Cog score, and the associations were stronger for daily moderate intensity activity than for daily step count. The 24-week combined intervention improved cognitive function and physical function in patients with MCI relative to controls. Encouraging participants to perform an additional 10 min of moderate physical activity under supervision, during ongoing intervention, may be more beneficial to prevent cognitive decline and improve exercise adherence.
C1 [Park, Hyuntae; Kim, Gwon Min; Jung, Mm Ki] Dong A Univ, Dept Hlth Care Sci, Busan 49315, South Korea.
   [Park, Hyuntae; Hiroyuki, Shimada] Natl Ctr Geriatr & Gerontol, Ctr Gerontol & Social Sci, Obu 4748511, Japan.
   [Park, Jong Hwan] Pusan Natl Univ Hosp, Biomed Res Inst, Hlth Convergence Med Res Grp, Busan 49241, South Korea.
   [Na, Hae Ri] Seongnam Ctr Senior Hlth, Dept Neurol, Gyeonggi Do 13552, South Korea.
   [Na, Hae Ri] Bobath Mem Hosp, Gyeonggi Do 13552, South Korea.
   [Kim, Woo Kyung; Park, Kyung Won] Busan Metropolitan Dementia Ctr, Busan 49201, South Korea.
   [Park, Kyung Won] Dong A Univ, Coll Med, Dept Neurol, Busan 49201, South Korea.
C3 Dong A University; National Center for Geriatrics & Gerontology; Pusan
   National University; Pusan National University Hospital; Dong A
   University
RP Park, KW (corresponding author), Busan Metropolitan Dementia Ctr, Busan 49201, South Korea.; Park, KW (corresponding author), Dong A Univ, Coll Med, Dept Neurol, Busan 49201, South Korea.
EM neuropark@dau.ac.kr
RI Park, Hyuntae/AAE-4672-2019
OI Park, Hyuntae/0000-0002-1976-0005; Park, Jong-Hwan/0000-0003-2815-7248
FU Dong-A University research grant
FX This research was funded by the Dong-A University research grant.
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NR 48
TC 46
Z9 47
U1 4
U2 45
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2019
VL 8
IS 7
AR 940
DI 10.3390/jcm8070940
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA IN9MO
UT WOS:000479003300027
PM 31261796
OA Green Published, gold, Green Submitted
DA 2023-08-17
ER

PT J
AU Martinez-Soldevila, J
   Pastells-Peiro, R
   Climent-Sanz, C
   Pinol-Ripoll, G
   Rocaspana-Garcia, M
   Gea-Sanchez, M
AF Martinez-Soldevila, Jordi
   Pastells-Peiro, Roland
   Climent-Sanz, Carolina
   Pinol-Ripoll, Gerard
   Rocaspana-Garcia, Mariona
   Gea-Sanchez, Montserrat
TI Effectiveness of technology-based interventions in detection,
   prevention, monitoring and treatment of patients at risk or diagnosed
   with mild cognitive impairment: protocol for a systematic review
SO BMJ OPEN
LA English
DT Review
DE health informatics; geriatric medicine; mental health; dementia;
   preventive medicine
ID OLDER-PEOPLE
AB Introduction The gradual changes over the decades in the longevity and ageing of European society as a whole can be directly related to the prolonged decline in the birth rate and increase in the life expectancy. According to the WHO, there is an increased risk of dementia or other cognitive disorders as the population ages, which have a major impact on public health. Mild cognitive impairment (MCI) is described as a greater than expected cognitive decline for an individual's age and level of education, but that does not significantly interfere with activities of daily living. Patients with MCI exhibit a higher risk of dementia compared with others in the same age group, but without a cognitive decline, have impaired walking and a 50% greater risk of falling. The urban lifestyle and advent of smartphones, mobility and immediate access to all information via the internet, including health information, has led to a totally disruptive change in most general aspects. This systematic review protocol is aimed at evaluating the effectiveness of technology-based interventions in the detection, prevention, monitoring and treatment of patients at risk or diagnosed with MCI. Methods and analysis This review protocol follows the recommendations of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols reporting guidelines. The search will be performed on MEDLINE (PubMed), CENTRAL, CINAHL Plus, ISI Web of Science and Scopus databases from 2010 to 2020. Studies of interventions either randomised clinical trials or pre-post non-randomised quasi-experimental designs, published in English and Spanish will be included. Articles that provide relevant information on the use of technology and its effectiveness in interventions that assess improvements in early detection, prevention, follow-up and treatment of the patients at risk or diagnosed with MCI will be included. Ethics and dissemination Ethics committee approval not required. The results will be disseminated in publications and congresses.
C1 [Martinez-Soldevila, Jordi; Pastells-Peiro, Roland; Climent-Sanz, Carolina; Rocaspana-Garcia, Mariona; Gea-Sanchez, Montserrat] Univ Lleida, Dept Nursing & Physiotherapy, Lleida, Spain.
   [Martinez-Soldevila, Jordi; Pastells-Peiro, Roland; Climent-Sanz, Carolina; Rocaspana-Garcia, Mariona; Gea-Sanchez, Montserrat] IRBLLEIDA, Lleida Inst Biomed Res Dr Pifarre Fdn, Hlth Care Res Grp GRECS, Lleida 25198, Spain.
   [Martinez-Soldevila, Jordi; Pastells-Peiro, Roland; Climent-Sanz, Carolina; Rocaspana-Garcia, Mariona; Gea-Sanchez, Montserrat] Univ Lleida, Grp dEstudis Societat Salut Educacio Cultura G, Lleida, Spain.
   [Pinol-Ripoll, Gerard] Clin Neurosci Res, Inst Recerca Biomed Lleida Fundacio Doctor Pifarr, Cognit Disorders Unit, Lleida, Spain.
C3 Universitat de Lleida; Universitat de Lleida
RP Climent-Sanz, C (corresponding author), Univ Lleida, Dept Nursing & Physiotherapy, Lleida, Spain.; Climent-Sanz, C (corresponding author), IRBLLEIDA, Lleida Inst Biomed Res Dr Pifarre Fdn, Hlth Care Res Grp GRECS, Lleida 25198, Spain.; Climent-Sanz, C (corresponding author), Univ Lleida, Grp dEstudis Societat Salut Educacio Cultura G, Lleida, Spain.
EM carol.climent@udl.cat
RI Gea-Sánchez, Montserrat/B-4043-2017; Climent-Sanz,
   Carolina/AAB-3457-2022; Pastells-Peiró, Roland/AAZ-2167-2020;
   Martínez-Soldevila, Jordi/ABD-4639-2021
OI Gea-Sánchez, Montserrat/0000-0001-5143-3314; Climent-Sanz,
   Carolina/0000-0001-6911-2164; Pastells-Peiró,
   Roland/0000-0002-9561-9038; Martínez-Soldevila,
   Jordi/0000-0001-9475-816X
FU European Commission [876487]; Agencia Estatal de Investigacion
   [AEI/10.13039/501100011033]; Ministry of Science and Innovation (MICINN)
   [PCI2020-112270]; CERCA Programme/Generalitat de Catalunya; IRBLleida
   Fundacio Dr. Pifarre
FX This paper is a result of the NEXTPERCEPTION project
   (www.nextperception.eu), which is jointly funded by the European
   Commission and national funding agencies under the ECSEL joint
   undertaking (grant agreement: 876487). This research was funded by the
   Agencia Estatal de Investigacion (AEI/10.13039/501100011033) Ministry of
   Science and Innovation (MICINN) (PCI2020-112270) CERCA
   Programme/Generalitat de Catalunya. IRBLleida Fundacio Dr. Pifarre.
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TC 0
Z9 0
U1 0
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2021
VL 11
IS 8
AR e045978
DI 10.1136/bmjopen-2020-045978
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UL9NB
UT WOS:000692968300036
PM 34408030
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Bajwa, RK
   Goldberg, SE
   Van der Wardt, V
   Burgon, C
   Di Lorito, C
   Godfrey, M
   Dunlop, M
   Logan, P
   Masud, T
   Gladman, J
   Smith, H
   Hood-Moore, V
   Booth, V
   Das Nair, R
   Pollock, K
   Vedhara, K
   Edwards, RT
   Jones, C
   Hoare, Z
   Brand, A
   Harwood, RH
AF Bajwa, Rupinder K.
   Goldberg, Sarah E.
   Van der Wardt, Veronika
   Burgon, Clare
   Di Lorito, Claudio
   Godfrey, Maureen
   Dunlop, Marianne
   Logan, Pip
   Masud, Tahir
   Gladman, John
   Smith, Helen
   Hood-Moore, Vicky
   Booth, Vicky
   Das Nair, Roshan
   Pollock, Kristian
   Vedhara, Kavita
   Edwards, Rhiannon Tudor
   Jones, Carys
   Hoare, Zoe
   Brand, Andrew
   Harwood, Rowan H.
TI A randomised controlled trial of an exercise intervention promoting
   activity, independence and stability in older adults with mild cognitive
   impairment and early dementia (PrAISED) - A Protocol
SO TRIALS
LA English
DT Article
DE Dementia; Cognitive impairment; Activities of daily living;
   Physiotherapy; Occupational therapy; Falls prevention; Tailoring;
   Strength training; Balance training; Dual-task training
ID QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; ELDERLY PERSONS;
   FALL RISK; BALANCE; PEOPLE; PERFORMANCE; PREVENTION; INSTRUMENT
AB Background: People with dementia progressively lose cognitive and functional abilities. Interventions promoting exercise and activity may slow decline. We developed a novel intervention to promote activity and independence and prevent falls in people with mild cognitive impairment (MCI) or early dementia. We successfully undertook a feasibility randomised controlled trial (RCT) to refine the intervention and research delivery. We are now delivering a multi-centred RCT to evaluate its clinical and cost-effectiveness.
   Methods: We will recruit 368 people with MCI or early dementia (Montreal Cognitive Assessment score 13-25) and a family member or carer from memory assessment clinics, other community health or social care venues or an online register (the National Institute for Health Research Join Dementia Research). Participants will be randomised to an individually tailored activity and exercise programme delivered using motivational theory to promote adherence and continued engagement, with up to 50 supervised sessions over one year, or a brief falls prevention assessment (control). The intervention will be delivered in participants' homes by trained physiotherapists, occupational therapists and therapy assistants. We will measure disabilities in activities of daily living, physical activity, balance, cognition, mood, quality of life, falls, carer strain and healthcare and social care use. We will use a mixed methods approach to conduct a process evaluation to assess staff training and delivery of the intervention, and to identify individual- and context-level mechanisms affecting intervention engagement and activity maintenance. We will undertake a health economic evaluation to determine if the intervention is cost-effective.
   Discussion: We describe the protocol for a multi-centre RCT that will evaluate the clinical and cost-effectiveness of a therapy programme designed to promote activity and independence amongst people living with dementia.
C1 [Bajwa, Rupinder K.; Van der Wardt, Veronika; Burgon, Clare; Di Lorito, Claudio; Logan, Pip; Masud, Tahir; Gladman, John; Booth, Vicky] Univ Nottingham, Divison Rehabil Ageing & Wellbeing, Nottingham NG7 2UH, England.
   [Goldberg, Sarah E.; Burgon, Clare; Hood-Moore, Vicky; Pollock, Kristian; Harwood, Rowan H.] Univ Nottingham, Sch Hlth Sci, Nottingham NG7 2UH, England.
   [Godfrey, Maureen; Dunlop, Marianne] Patient & Publ Involvement Collaborator, Nottingham, England.
   [Masud, Tahir; Gladman, John; Booth, Vicky; Harwood, Rowan H.] Nottingham Univ Hosp NHS Trust, Queens Med Ctr, Healthcare Older People, Nottingham NG7 2UH, England.
   [Smith, Helen] Nottinghamshire Healthcare NHS Fdn Trust, Highbury Hosp, Mental Hlth Serv Older People, Nottingham NG6 9RD, England.
   [Das Nair, Roshan] Univ Nottingham, Inst Mental Hlth, Nottingham NG8 1BB, England.
   [Vedhara, Kavita] Univ Nottingham, Div Primary Care, Nottingham NG7 2RD, England.
   [Edwards, Rhiannon Tudor; Jones, Carys] Bangor Univ, Ctr Hlth Econ & Med Evaluat, Bangor LL57 2PZ, Gwynedd, Wales.
   [Hoare, Zoe; Brand, Andrew] Bangor Univ, North Wales Org Randomised Trials Hlth Clin Trial, Bangor LL57 2PZ, Gwynedd, Wales.
C3 University of Nottingham; University of Nottingham; Nottingham
   University Hospital NHS Trust; University of Nottingham; University of
   Nottingham; University of Nottingham; Bangor University; Bangor
   University
RP Bajwa, RK (corresponding author), Univ Nottingham, Divison Rehabil Ageing & Wellbeing, Nottingham NG7 2UH, England.
EM Rupinder.Bajwa@nottingham.ac.uk
RI van der Wardt, Veronika/ABF-3836-2021; Pollock, Kristian/B-9734-2008
OI van der Wardt, Veronika/0000-0003-3995-7056; Pollock,
   Kristian/0000-0002-6836-8595; Harwood, Rowan/0000-0002-4920-6718; Logan,
   Philippa/0000-0002-6657-2381; Di Lorito, Claudio/0000-0002-8953-0117;
   Stringer, Carys/0000-0001-6159-1842; Goldberg,
   Sarah/0000-0001-5109-798X; Booth, Vicky/0000-0002-5338-0196
FU UK National Institute for Health Research (NIHR) [RP-PG-0614-20007];
   National Institutes of Health Research (NIHR) [RP-PG-0614-20007] Funding
   Source: National Institutes of Health Research (NIHR)
FX This protocol presents independent research funded by the UK National
   Institute for Health Research (NIHR) under its Programme Grants for
   Applied Research funding scheme (RP-PG-0614-20007). The views expressed
   are those of the authors and not necessarily those of the NHS, the NIHR
   or the Department of Health and Social Care. The study underwent peer
   review as part of the funding application procedure, with feedback being
   incorporated into the final protocol. The sponsor and funders had no
   further role in study design; data collection, management, analysis, or
   interpretation of data; writing of the report; or the decision to submit
   the report for publication.
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NR 65
TC 14
Z9 14
U1 7
U2 47
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD DEC 30
PY 2019
VL 20
IS 1
AR 815
DI 10.1186/s13063-019-3871-9
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA KC0QI
UT WOS:000506892200027
PM 31888709
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Cuc, AV
   Locke, DEC
   Duncan, N
   Fields, JA
   Snyder, CH
   Hanna, S
   Lunde, A
   Smith, GE
   Chandler, M
AF Cuc, Andrea V.
   Locke, Dona E. C.
   Duncan, Noah
   Fields, Julie A.
   Snyder, Charlene Hoffman
   Hanna, Sherrie
   Lunde, Angela
   Smith, Glenn E.
   Chandler, Melanie
TI A pilot randomized trial of two cognitive rehabilitation interventions
   for mild cognitive impairment: caregiver outcomes
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE mild cognitive impairment; caregivers; behavioral intervention;
   cognitive rehabilitation
ID EARLY-STAGE DEMENTIA; CARE PARTNERS; MEMORY CLUB; FAMILY; IMPACT
AB ObjectiveThis study aims to provide effect size estimates of the impact of two cognitive rehabilitation interventions provided to patients with mild cognitive impairment: computerized brain fitness exercise and memory support system on support partners' outcomes of depression, anxiety, quality of life, and partner burden.
   MethodsA randomized controlled pilot trial was performed.
   ResultsAt 6months, the partners from both treatment groups showed stable to improved depression scores, while partners in an untreated control group showed worsening depression over 6months. There were no statistically significant differences on anxiety, quality of life, or burden outcomes in this small pilot trial; however, effect sizes were moderate, suggesting that the sample sizes in this pilot study were not adequate to detect statistical significance.
   ConclusionEither form of cognitive rehabilitation may help partners' mood, compared with providing no treatment. However, effect size estimates related to other partner outcomes (i.e., burden, quality of life, and anxiety) suggest that follow-up efficacy trials will need sample sizes of at least 30-100 people per group to accurately determine significance. Copyright (c) 2017 John Wiley & Sons, Ltd.
C1 [Cuc, Andrea V.; Locke, Dona E. C.] Mayo Clin Arizona, Div Psychol, Phoenix, AZ 85054 USA.
   [Duncan, Noah] Naval Hosp Jacksonville, Jacksonville, FL USA.
   [Fields, Julie A.; Hanna, Sherrie; Lunde, Angela] Mayo Clin Rochester, Div Neurocognit Disorders, Rochester, MN USA.
   [Snyder, Charlene Hoffman] Mayo Clin Arizona, Dept Neurol, Phoenix, AZ 85054 USA.
   [Smith, Glenn E.] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL USA.
   [Chandler, Melanie] Mayo Clin Florida, Div Psychol, Jacksonville, FL USA.
C3 Mayo Clinic; Mayo Clinic Phoenix; Mayo Clinic; Mayo Clinic; Mayo Clinic
   Phoenix; State University System of Florida; University of Florida; Mayo
   Clinic
RP Locke, DEC (corresponding author), Mayo Clin Arizona, Div Psychol, Phoenix, AZ 85054 USA.
EM locke.dona@mayo.edu
FU NINR [R01 NR012419]; PCORI [CER-1306-01897]; NIA [P30AG19610,
   R01AG031581]; Arizona Alzheimer's Research Consortium; Mayo Clinic
   Rochester; Mayo Alzheimer's Disease Research Center [P50 AG16574]; Emory
   University; Alzheimer's Association [NIRG-07-58843]; Emory Alzheimer's
   Disease Research Center [AG025688]; REDCap database grant support [UL1
   TR000135]
FX This study was supported by NINR (R01 NR012419) and PCORI
   (CER-1306-01897) for all sites. The following are also acknowledged:
   additional Arizona support, NIA (P30AG19610 and R01AG031581) and the
   Arizona Alzheimer's Research Consortium; additional Mayo Clinic
   Rochester support, Mayo Alzheimer's Disease Research Center (P50
   AG16574); additional Emory University support, Alzheimer's Association
   (NIRG-07-58843) and Emory Alzheimer's Disease Research Center
   (AG025688); and REDCap database grant support (UL1 TR000135).
CR Albert MS, 2011, ALZHEIMERS DEMENT, V7, P270, DOI 10.1016/j.jalz.2011.03.008
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NR 24
TC 7
Z9 7
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD DEC
PY 2017
VL 32
IS 12
BP E180
EP E187
DI 10.1002/gps.4689
PG 8
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA FO0HV
UT WOS:000416425200022
PM 28233343
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Farhang, M
   Rojas, G
   Martinez, P
   Behrens, MI
   Langer, AI
   Diaz, M
   Miranda-Castillo, C
AF Farhang, Maryam
   Rojas, Graciela
   Martinez, Pablo
   Isabel Behrens, Maria
   Langer, Alvaro, I
   Diaz, Marcela
   Miranda-Castillo, Claudia
TI The Impact of a Yoga-Based Mindfulness Intervention versus
   Psycho-Educational Session for Older Adults with Mild Cognitive
   Impairment: The Protocol of a Randomized Controlled Trial
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE older people; mild cognitive impairment; yoga; mindfulness; mind-body
   intervention
ID ALZHEIMERS-DISEASE; DEPRESSIVE SYMPTOMS; ANXIETY INVENTORY; HATHA YOGA;
   DEMENTIA; RISK; ASSOCIATION; BALANCE; HEALTH; CARE
AB Background: There is a global agreement in the medical community that a significant proportion of dementia cases could be prevented or postponed. One of the factors behind this agreement comes from scientific evidence showing that mind-body interventions such as mindfulness and yoga for the elderly have been related to a range of positive outcomes, including improved cognition performance in seniors with mild cognitive impairment (MCI). Objective: This study aims to evaluate the effectiveness of a yoga-based mindfulness intervention (YBM) versus psychoeducational sessions for older adults with MCI attending Hospital Clinic Universidad de Chile in Santiago. Method: Two-arm, individually randomized controlled trial (RCT) will be carried out at Clinical Hospital Universidad de Chile in Santiago. Older people over 60 years with any type of MCI using a score < 21 in the Montreal Cognitive Assessment (MoCA) test and a score of 0.05 in the Clinical Dementia Rating (CDR) Scale; and with preserved activities of daily living will be randomly assigned with an allocation ratio of 1:1 in either the yoga-based mindfulness intervention or the active control group based on the psycho-educational program. People who have performed yoga and/or mindfulness in the last 6 months or/and people with a psychiatric clinical diagnosis will be excluded from the study. Montreal Cognitive Assessment, the Lawton Instrumental Activities of Daily Living Scale (IADL), the Barthel Index (BI), the Pemberton happiness index, the Geriatric Anxiety Inventory (GAI) as well as the Geriatric Depression Scale (GDS-5) will be administered by blinded outcomes assessors before random assignment (Pre-test), the week following the last session of the intervention (post-test), and then after 3- and 6-months follow-up. Results: The YBM intervention protocol based on a video recording has been adapted and designed. This is the first RCT to examine the effects of a yoga-based mindfulness intervention in improving cognitive and physical functions and mental health outcomes for Chilean elderly diagnosed with MCI. It is expected to be implemented as an acceptable and effective non-pharmacological option for older people with MCI. Conclusion: Providing evidence-based programs such as preventive therapy for Alzheimer's disease has relevant implications for public mental health services in Chile.
C1 [Farhang, Maryam] Univ Amer, Fac Salud & Ciencias Sociales, Escuela Enfermeria, Santiago 8370040, Chile.
   [Farhang, Maryam; Rojas, Graciela; Langer, Alvaro, I; Miranda-Castillo, Claudia] Millennium Inst Res Depress & Personal MIDAP, Santiago 8380453, Chile.
   [Farhang, Maryam; Miranda-Castillo, Claudia] Millennium Inst Care Res MICARE, Santiago 8370134, Chile.
   [Farhang, Maryam; Rojas, Graciela] Hosp Clin Univ Chile, Dept Psiquiatria & Salud Mental, Santiago 8380456, Chile.
   [Farhang, Maryam; Rojas, Graciela; Langer, Alvaro, I] Millennium Nucleus Improve Mental Hlth Adolescent, Santiago 8380455, Chile.
   [Martinez, Pablo] Univ Sherbrooke, Fac Med & Sci Sante, 150 Pl Charles Moyne, Longueuil, PQ J4K A08, Canada.
   [Isabel Behrens, Maria] Hosp Clin Univ Chile, Ctr Invest Clin Avanzada CICA, Santiago 8380456, Chile.
   [Isabel Behrens, Maria] Hosp Clin Univ Chile, Dept Neurol & Neurocirugia, Santiago 8380456, Chile.
   [Isabel Behrens, Maria] Univ Chile, Fac Med, Dept Neurociencia, Santiago 7800284, Chile.
   [Isabel Behrens, Maria] Univ Desarrollo, Dept Neurol & Psiquiatria, Clin Alemana Santiago, Santiago 7800284, Chile.
   [Langer, Alvaro, I] Austral Univ, Inst Psychol Studies, Mind Body Lab, Valdivia 5110566, Chile.
   [Diaz, Marcela] Univ Chile, Clin Psiquiatr Univ, Hosp Clin, Santiago 7800284, Chile.
   [Miranda-Castillo, Claudia] Univ Andres Bello, Fac Nursing, Santiago 7550000, Chile.
C3 Universidad de Las Americas - Chile; Universidad de Chile; University of
   Sherbrooke; Universidad de Chile; Universidad de Chile; Universidad de
   Chile; Clinica Alemana; Universidad del Desarrollo; Universidad Austral
   de Chile; Universidad de Chile; Universidad Andres Bello
RP Farhang, M (corresponding author), Univ Amer, Fac Salud & Ciencias Sociales, Escuela Enfermeria, Santiago 8370040, Chile.; Farhang, M (corresponding author), Millennium Inst Res Depress & Personal MIDAP, Santiago 8380453, Chile.; Farhang, M (corresponding author), Millennium Inst Care Res MICARE, Santiago 8370134, Chile.; Farhang, M (corresponding author), Hosp Clin Univ Chile, Dept Psiquiatria & Salud Mental, Santiago 8380456, Chile.; Farhang, M (corresponding author), Millennium Nucleus Improve Mental Hlth Adolescent, Santiago 8380455, Chile.
EM mfarhang@udla.cl
RI Behrens, Maria I I/I-1083-2013; Castillo, Claudia Miranda/F-5360-2013
OI Behrens, Maria I I/0000-0003-0964-426X; Langer,
   Alvaro/0000-0003-2983-5274
FU National Fund for Scientific and Technological Development [ANID
   FONDECYT 3190275, ANID FONDECYT 1180224]; ANID Millennium Science
   Initiative Program [ICS13_005, ICS2019_024, NCS17_035]; Millennium
   Science Initiative Program [ICS2019_024]; ANID FONDECYT [1191726,
   1190958]
FX M.F. received funding from National Fund for Scientific and
   Technological Development through the grant ANID FONDECYT 3190275 as
   well as supported by the ANID Millennium Science Initiative
   Program-ICS13_005 and Millennium Science Initiative Program ICS2019_024
   to perform this study. Additionally, C.M.-C. received funding from ANID
   Millennium Science Initiative Program-ICS2019_024 and ICS13_005, as well
   as ANID FONDECYT 1191726. Moreover, M.I.B. received funding from ANID
   FONDECYT 1190958. Furthermore, P.M. received funding from ANID
   Millennium Science Initiative Program-NCS17_035, and the ANID Millennium
   Science Initiative Program-ICS13_005, and the National Fund for
   Scientific and Technological Development through the grant ANID FONDECYT
   1180224. Finally, G.R. and A.I.L. received funding from ANID-Millennium
   Science Initiative Program-ICS13_005. Funding parties have no role in
   the design, management, analysis, and reporting of the study.
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NR 85
TC 1
Z9 1
U1 10
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2022
VL 19
IS 22
AR 15374
DI 10.3390/ijerph192215374
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 6K0FR
UT WOS:000887190100001
PM 36430097
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Cammisuli, D
   Pinori, F
   Verdiani, C
   Sportiello, MT
AF Cammisuli, D.
   Pinori, F.
   Verdiani, C.
   Sportiello, Timpano M.
TI Cognitive activation intervention on mild cognitive impairment subjects
   and mild demented patients: A pilot-study
SO PSYCHOLOGY & HEALTH
LA English
DT Meeting Abstract
C1 [Cammisuli, D.] Univ Pisa, I-56100 Pisa, Italy.
C3 University of Pisa
NR 0
TC 0
Z9 0
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0887-0446
EI 1476-8321
J9 PSYCHOL HEALTH
JI Psychol. Health
PY 2009
VL 24
SU 1
SI SI
BP 118
EP 118
PG 1
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA V26IN
UT WOS:000208539400302
DA 2023-08-17
ER

PT J
AU Roy, M
   Edde, M
   Fortier, M
   Croteau, E
   Castellano, CA
   St-Pierre, V
   Vandenberghe, C
   Rheault, F
   Dadar, M
   Duchesne, S
   Bocti, C
   Fulop, T
   Cunnane, SC
   Descoteaux, M
AF Roy, Maggie
   Edde, Manon
   Fortier, Melanie
   Croteau, Etienne
   Castellano, Christian-Alexandre
   St-Pierre, Valerie
   Vandenberghe, Camille
   Rheault, Francois
   Dadar, Mahsa
   Duchesne, Simon
   Bocti, Christian
   Fulop, Tamas
   Cunnane, Stephen C.
   Descoteaux, Maxime
TI A ketogenic intervention improves dorsal attention network functional
   and structural connectivity in mild cognitive impairment
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Mild cognitive impairment; Functional connectivity; Structural
   connectivity; Dorsal attention network; Ketone; Medium chain
   triglyceride
ID DEFAULT-MODE NETWORK; DUAL-TRACER PET; ALZHEIMERS-DISEASE; BRAIN
   GLUCOSE; DIET; MEMORY; METABOLISM; FAILURE; RESERVE; SYSTEMS
AB Ketones, the brain's alternative fuel to glucose, bypass the brain glucose deficit and improve cognition in mild cognitive impairment (MCI). Our goal was to assess the impact of a 6-month ketogenic inter-vention on the functional connectivity within eight major brain resting-state networks, and its possible relationship to improved cognitive outcomes in the BENEFIC trial. MCI participants were randomized to a placebo ( n = 15) or ketogenic medium chain triglyceride (kMCT; n = 17) intervention. kMCT was associ-ated with increased functional connectivity within the dorsal attention network (DAN), which correlated to improvement in cognitive tests targeting attention. Ketone uptake ( 11 C-acetoacetate PET) specifically in DAN cortical regions was highly increased in the kMCT group and was directly associated with the improved DAN functional connectivity. Analysis of the structural connectome revealed increased fiber density within the DAN following kMCT. Our findings suggest that ketones in MCI may prove beneficial for cognition at least in part because they improve brain network energy status, functional connectivity and axonal integrity. (c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
C1 [Roy, Maggie; Fortier, Melanie; St-Pierre, Valerie; Vandenberghe, Camille; Bocti, Christian; Fulop, Tamas; Cunnane, Stephen C.; Descoteaux, Maxime] CHUS, CIUSSS Estrie, Res Ctr Aging, Sherbrooke, PQ, Canada.
   [Roy, Maggie; Cunnane, Stephen C.] Univ Sherbrooke, Dept Pharmacol & Physiol, Sherbrooke, PQ, Canada.
   [Roy, Maggie; Edde, Manon; Fortier, Melanie; Croteau, Etienne; Castellano, Christian-Alexandre; St-Pierre, Valerie; Vandenberghe, Camille; Rheault, Francois] Univ Laval, Dept Radiol & Nucl Med, Quebec City, PQ, Canada.
   [Croteau, Etienne] CERVO Brain Res Ctr, Quebec City, PQ, Canada.
   [Roy, Maggie; Edde, Manon; Fortier, Melanie; Croteau, Etienne; Castellano, Christian-Alexandre; St-Pierre, Valerie; Vandenberghe, Camille; Rheault, Francois] Univ Sherbrooke, Dept Med, Sherbrooke, PQ, Canada.
   [Dadar, Mahsa; Duchesne, Simon] Univ Sherbrooke, Dept Comp Sci, Sherbrooke, PQ, Canada.
   [Dadar, Mahsa; Duchesne, Simon] Ctr Rech, CHUS, CIUSSS Estrie CHUS, Sherbrooke, PQ, Canada.
   [Bocti, Christian] Quebec Heart & Lung Inst, Quebec City, PQ, Canada.
   [Roy, Maggie] Imeka Solut Inc, 195 Belvedere North, Sherbrooke, PQ J1H 4A7, Canada.
C3 University of Sherbrooke; University of Sherbrooke; Laval University;
   University of Sherbrooke; University of Sherbrooke; University of
   Sherbrooke; Quebec Heart & Lung Institute
RP Roy, M (corresponding author), Imeka Solut Inc, 195 Belvedere North, Sherbrooke, PQ J1H 4A7, Canada.
EM Maggie.roy@imeka.ca
RI Duchesne, Simon/O-4852-2016; Roy, Maggie/ABC-6221-2020
OI Duchesne, Simon/0000-0002-6326-0745; Roy, Maggie/0000-0002-6503-6747;
   Fortier, Melanie/0000-0002-4323-7521
FU Alzheimer Association USA [PCTR-15-328047]; FRQS [FR40072]; Universite
   de Sherbrooke, MITACS; Nestle Health Science; Sanofi; Pfizer; Universite
   de Sherbrooke Institutional Chair in Neuroinformatics; NSERC
FX The authors wish to acknowledge the PET and MRI clinical teams at the
   Sherbrooke Molecular Imaging Center, Dr Sebastien Tremblay, Francis
   Langlois and Marie-Christine Morin for technical assistance and the
   Sherbrooke Connectivity Imaging Lab team for their help on data
   processing. We would also like to acknowledge the participants of the
   BENEFIC trial.; Financial support for the BENEFIC trial was provided by
   the Alzheimer Association USA (PCTR-15-328047) , FRQS (FR40072) ,
   Universite de Sherbrooke, MITACS (MR) and Nestle Health Science. TF was
   funded by Sanofi and Pfizer. The Universite de Sherbrooke Institutional
   Chair in Neuroinformatics and NSERC also provided funding support.
   Abitec provided the kMCT (Captex 355) and placebo oil. The intervention
   drinks for both arms were prepared under contract at INAF, Universite
   Laval, Quebec, QC, Canada.
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NR 89
TC 6
Z9 6
U1 1
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0197-4580
EI 1558-1497
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD JUL
PY 2022
VL 115
BP 77
EP 87
DI 10.1016/j.neurobiolaging.2022.04.005
EA APR 2022
PG 11
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 1M5RJ
UT WOS:000800025900002
PM 35504234
OA hybrid
DA 2023-08-17
ER

PT J
AU Han, A
AF Han, Areum
TI Mindfulness-Based Interventions for Older Adults with Dementia or Mild
   Cognitive Impairment: A Meta-Analysis
SO CLINICAL GERONTOLOGIST
LA English
DT Article
DE Aged; anxiety; cognitive dysfunction; dementia; depression;
   meta-analysis; memory; mindfulness; systematic review; quality of life
ID STRESS REDUCTION; MEDITATION; BENEFITS; HEALTH; YOGA
AB Objectives This systematic review and meta-analysis examined the effects of mindfulness-based interventions (MBIs) on psychological symptoms, cognitive functions, and quality of life in older adults with dementia or mild cognitive impairment (MCI). Methods A comprehensive search was conducted within four databases to identify relevant randomized controlled trials (RCTs). Heterogeneity was assessed using the I-2 statistic. Depending on I-2 statistic values, either a random effects model or fixed effects model was used. Results 10 RCTs published in 11 articles met the eligibility criteria. The present meta-analysis study found no significant effect of MBIs on depressive symptoms, anxiety, quality of life, memory, and overall cognitive functions compared to control groups. Conclusions Future high-quality studies involving different types of MBIs are needed to better understand the effects of MBIs on psychological symptoms, quality of life, and cognitive functions in older adults with MCI and dementia and examine effective intervention features. Clinical Implications There is insufficient evidence to determine whether or not practitioners should be routinely providing MBIs to older adults with MCI and dementia due to the lack of studies currently.
C1 [Han, Areum] Univ Alabama Birmingham, Dept Occupat Therapy, SHPB 340,1720 2nd Ave South, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Han, A (corresponding author), Univ Alabama Birmingham, Dept Occupat Therapy, SHPB 340,1720 2nd Ave South, Birmingham, AL 35294 USA.
EM ahan@uab.edu
OI Han, Areum/0000-0003-1369-9052
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NR 40
TC 10
Z9 10
U1 4
U2 17
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-7115
EI 1545-2301
J9 CLIN GERONTOLOGIST
JI Clin. Gerontol.
PD AUG 8
PY 2022
VL 45
IS 4
BP 763
EP 776
DI 10.1080/07317115.2021.1995561
EA OCT 2021
PG 14
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 2D9QH
UT WOS:000710401600001
PM 34693892
DA 2023-08-17
ER

PT J
AU Chien, YC
   Chao, AA
   Chieh, LC
   Yen, YC
   Kao, HSR
   Shen, YT
AF Chien, Yueh-Chuan
   Chao, An An
   Chieh, Lin C.
   Yen, Yu-Chun
   Kao, Henry S. R.
   Shen, Yu-Ting
TI PSYCHO-EMOTIONAL EFFECTS OF CHINESE CALLIGRAPHY HANDWRITING (CCH)
   INTERVENTION IN PERSONS WITH MILD COGNITIVE IMPAIRMENT
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Meeting Abstract
C1 [Chien, Yueh-Chuan] Natl Univ Tainan, Tainan, Taiwan.
   [Chao, An An] Chung Yuan Christian Univ, Taoyuan 325, Taiwan.
   [Chieh, Lin C.] Triserv Gen Hosp, Taipei, Taiwan.
   [Yen, Yu-Chun; Shen, Yu-Ting] Taipei Med Univ, Taipei, Taiwan.
   [Kao, Henry S. R.] Univ Hong Kong, Taipei, Taiwan.
C3 National University Tainan; Chung Yuan Christian University; Tri-Service
   General Hospital; Taipei Medical University; University of Hong Kong
EM crjpf@gm2.nutn.edu.tw
NR 0
TC 0
Z9 0
U1 2
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD MAY
PY 2020
VL 54
SU 1
MA B103
BP S259
EP S259
PG 1
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA MG8ED
UT WOS:000546262400545
DA 2023-08-17
ER

PT J
AU Jenkins, E
   Koirala, B
   Rodney, T
   Lee, JW
   Cotter, VT
   Szanton, SL
   Taylor, JL
AF Jenkins, Emerald
   Koirala, Binu
   Rodney, Tamar
   Lee, Ji Won
   Cotter, Valerie T.
   Szanton, Sarah L.
   Taylor, Janiece L.
TI Home/community-based interventions to improve function in persons with
   mild cognitive impairment/early dementia
SO GERIATRIC NURSING
LA English
DT Article
DE Physical function; Executive function; Mild cognitive impairment; Early
   dementia; Intervention; Home
ID ADAPTATION THERAPY PATH; NURSING-HOME RESIDENTS; OLDER-ADULTS;
   PHYSICAL-ACTIVITY; IMPACT; EXERCISE; HEALTH; METAANALYSIS; DECLINE;
   DISEASE
AB Persons with mild cognitive impairment/early dementia have a possible 20-year trajectory of disability and dependence with little information on the effectiveness of interventions to improve function. This review investigates the literature of home/community-based interventions for physical and executive function in persons with mild cognitive impairment/early dementia. A 2007-2020 systematic literature search was conducted through PubMed, CINAHL Plus with Full Text and PsycINFO. Of the 1749 articles retrieved, 18 eligible studies were identified and consisted of three types of interventions: cognitive training-only (n = 7), multicomponent (n = 9), and physical activity-only (n = 2). Results showed that the interventions impacting function in persons with cognitive impairment incorporated a visual/written element, technology-based training, caregiver support, and modified duration/increased frequency of interventions. In studies improving function, participants simulated Instrumental Activities of Daily Living. They addressed cognitive function using both objective and subjective cognitive measures. We found gaps in the literature in incorporating race/ethnicity and appropriate socioeconomic status measures. (C) 2021 Elsevier Inc. All rights reserved.
C1 [Jenkins, Emerald; Koirala, Binu; Rodney, Tamar; Lee, Ji Won; Cotter, Valerie T.; Taylor, Janiece L.] Johns Hopkins Univ, Sch Nursing, 525 N Wolfe St,929 N Wolfe St,Room 403,Room 422, Baltimore, MD 21205 USA.
   [Szanton, Sarah L.] Johns Hopkins Sch Nursing, Johns Hopkins Bloomberg Sch Publ Hlth, Hlth Equity & Social Justice Endowed, Ctr Innovat Care Aging,Dept Hlth Policy & Managem, 525 North Wolfe St 424, Baltimore, MD 21205 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health
RP Jenkins, E (corresponding author), Johns Hopkins Univ, Sch Nursing, 525 N Wolfe St,929 N Wolfe St,Room 403,Room 422, Baltimore, MD 21205 USA.
EM erivers5@jhmi.edu
RI Cotter, Valerie T/A-1083-2007; Rodney, Tamar/S-2223-2018
OI Cotter, Valerie T/0000-0002-0222-9867; Jenkins,
   Emerald/0000-0002-5569-6709; Rodney, Tamar/0000-0002-0187-985X; Lee, Ji
   Won/0000-0001-8680-8673
FU National Center for Advancing Translational Science (NCATS) a component
   of the National Institutes of Health (NIH) [TL1 TR003100]; NIH Roadmap
   for Medical Research; NIH NIA [R36AG07210-01]; Rita and Alex Hillman
   Foundation; NIDILRR
FX This publication was made possible by the Johns Hopkins Institute for
   Clinical and Translational Research (ICTR) which is funded in part by
   TL1 TR003100 from the National Center for Advancing Translational
   Science (NCATS) a component of the National Institutes of Health (NIH),
   and NIH Roadmap for Medical Research. Its contents are solely the
   responsibility of the authors and do not necessarily represent the
   official view of the Johns Hopkins ICTR, NCATS or NIH. NIH NIA
   (R36AG07210-01), the Rita and Alex Hillman Foundation, and NIDILRR also
   provided funding for the authors.
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NR 77
TC 2
Z9 2
U1 5
U2 23
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4572
EI 1528-3984
J9 GERIATR NURS
JI Geriatr. Nurs.
PD SEP-OCT
PY 2021
VL 42
IS 5
BP 1109
EP 1124
DI 10.1016/j.gerinurse.2021.06.023
EA JUL 2021
PG 16
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA WE9FD
UT WOS:000705922500021
PM 34280736
OA Green Accepted
DA 2023-08-17
ER

PT J
AU James, CE
   Stucker, C
   Junker-Tschopp, C
   Fernandes, AM
   Revol, A
   Mili, ID
   Kliegel, M
   Frisoni, GB
   Guevara, AB
   Marie, D
AF James, C. E.
   Stucker, C.
   Junker-Tschopp, C.
   Fernandes, A. M.
   Revol, A.
   Mili, I. D.
   Kliegel, M.
   Frisoni, G. B.
   Guevara, A. Brioschi
   Marie, D.
TI Musical and psychomotor interventions for cognitive, sensorimotor, and
   cerebral decline in patients with Mild Cognitive Impairment (COPE): a
   study protocol for a multicentric randomized controlled study
SO BMC GERIATRICS
LA English
DT Article
DE Mild cognitive impairment; Randomized controlled trial; Non-medical
   interventions; Cognitive performance; Sensorimotor performance;
   Experience induced functional and structural brain plasticity; Music
   instrumental practice; Psychomotor therapy; Passive control group;
   Multivariate data-driven analyses
ID MINI-MENTAL-STATE; WORKING-MEMORY; OLDER-ADULTS; EXECUTIVE FUNCTIONS;
   PHYSICAL-ACTIVITY; INHIBITORY CONTROL; BRAIN PLASTICITY; HEALTHY;
   EXERCISE; BENEFITS
AB BackgroundRegular cognitive training can boost or maintain cognitive and brain functions known to decline with age. Most studies administered such cognitive training on a computer and in a lab setting. However, everyday life activities, like musical practice or physical exercise that are complex and variable, might be more successful at inducing transfer effects to different cognitive domains and maintaining motivation. "Body-mind exercises", like Tai Chi or psychomotor exercise, may also positively affect cognitive functioning in the elderly. We will compare the influence of active music practice and psychomotor training over 6 months in Mild Cognitive Impairment patients from university hospital memory clinics on cognitive and sensorimotor performance and brain plasticity. The acronym of the study is COPE (Countervail cOgnitive imPairmEnt), illustrating the aim of the study: learning to better "cope" with cognitive decline.MethodsWe aim to conduct a randomized controlled multicenter intervention study on 32 Mild Cognitive Impairment (MCI) patients (60-80 years), divided over 2 experimental groups: 1) Music practice; 2) Psychomotor treatment. Controls will consist of a passive test-retest group of 16 age, gender and education level matched healthy volunteers.The training regimens take place twice a week for 45 min over 6 months in small groups, provided by professionals, and patients should exercise daily at home. Data collection takes place at baseline (before the interventions), 3, and 6 months after training onset, on cognitive and sensorimotor capacities, subjective well-being, daily living activities, and via functional and structural neuroimaging. Considering the current constraints of the COVID-19 pandemic, recruitment and data collection takes place in 3 waves.DiscussionWe will investigate whether musical practice contrasted to psychomotor exercise in small groups can improve cognitive, sensorimotor and brain functioning in MCI patients, and therefore provoke specific benefits for their daily life functioning and well-being.
C1 [James, C. E.; Stucker, C.; Fernandes, A. M.; Marie, D.] Univ Appl Sci & Arts Western Switzerland HES so, Geneva Sch Hlth Sci, Geneva Mus Minds Lab, GEMMI lab, Ave Champel 47, CH-1206 Geneva, Switzerland.
   [James, C. E.] Univ Geneva, Fac Psychol & Educ Sci, Blvd Carl Vogt 101, CH-1205 Geneva, Switzerland.
   [Junker-Tschopp, C.; Revol, A.] Univ Appl Sci & Arts Western Switzerland HES SO, Geneva Sch Social Work, Dept Psychomotr, Rue Prevost Martin 28, CH-1205 Geneva, Switzerland.
   [Mili, I. D.] Univ Geneva, Fac Psychol & Educ Sci, Didact Arts & Movement Lab, Blvd Carl Vogt 101, CH-1205 Geneva, Switzerland.
   [Kliegel, M.] Univ Geneva, Fac Psychol & Educ Sci, Ctr Interdisciplinary Study Gerontol & Vulnerabil, Blvd Pont Arve 28, CH-1205 Geneva, Switzerland.
   [Frisoni, G. B.] Univ Geneva, Univ Hosp, Rue Gabrielle Perret Gentil 6, CH-1205 Geneva, Switzerland.
   [Frisoni, G. B.] Univ Geneva, Memory Ctr, Rue Gabrielle Perret Gentil 6, CH-1205 Geneva, Switzerland.
   [Guevara, A. Brioschi] Lausanne Univ Hosp, Leenaards Memory Ctr, Chemin Mont Paisible 16, CH-1011 Lausanne, Switzerland.
   [Marie, D.] Univ Hosp, Univ Geneva, Memory Ctr, Rue Gabrielle-Perret-Gentil 6, CH-1205 Geneva, Switzerland.
C3 University of Geneva; University of Geneva; University of Geneva;
   University of Geneva; University of Geneva; University of Lausanne;
   Centre Hospitalier Universitaire Vaudois (CHUV); University of Geneva
RP James, CE (corresponding author), Univ Appl Sci & Arts Western Switzerland HES so, Geneva Sch Hlth Sci, Geneva Mus Minds Lab, GEMMI lab, Ave Champel 47, CH-1206 Geneva, Switzerland.; James, CE (corresponding author), Univ Geneva, Fac Psychol & Educ Sci, Blvd Carl Vogt 101, CH-1205 Geneva, Switzerland.
EM clara.james@hesge.ch
OI James, Clara/0000-0001-7480-0682
FU Swiss Alzheimer Association (Association Alzheimer Suisse); Gebauer
   Stiftung (Swiss private foundation); Swiss Psychomotor Association
   (Association Psychomotricite Suisse); Private foundation (desiring to
   stay anonymous)
FX Swiss Alzheimer Association (Association Alzheimer Suisse). Gebauer
   Stiftung (Swiss private foundation). Swiss Psychomotor Association
   (Association Psychomotricite Suisse). Private foundation (desiring to
   stay anonymous). These funding bodies played no role in the design of
   the study and will not have any influence on its execution, analyses,
   interpretation of the results, or the submission of results to
   scientific journals or other kinds of dissemination. The Principal
   Investigator's host institution, the University of Applied Sciences and
   Arts, Western Switzerland HES-SO, provided all infrastructure and
   covered additional costs (COVID) necessaryto perform the study.
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NR 164
TC 0
Z9 0
U1 21
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD FEB 6
PY 2023
VL 23
IS 1
AR 76
DI 10.1186/s12877-022-03678-0
PG 20
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 8P5GK
UT WOS:000926551500001
PM 36747142
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Guerriero, F
   Botarelli, E
   Mele, G
   Polo, L
   Zoncu, D
   Renati, P
   Sgarlata, C
   Rollone, M
   Ricevuti, G
   Maurizi, N
   Francis, M
   Rondanelli, M
   Perna, S
   Guido, D
   Mannu, P
AF Guerriero, Fabio
   Botarelli, Emanuele
   Mele, Gianni
   Polo, Lorenzo
   Zoncu, Daniele
   Renati, Paolo
   Sgarlata, Carmelo
   Rollone, Marco
   Ricevuti, Giovanni
   Maurizi, Niccolo
   Francis, Matthew
   Rondanelli, Mariangela
   Perna, Simone
   Guido, Davide
   Mannu, Piero
TI An innovative intervention for the treatment of cognitive
   impairment-Emisymmetric bilateral stimulation improves cognitive
   functions in Alzheimer's disease and mild cognitive impairment: an
   open-label study
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE pulsed electromagnetic fields; cognitive decline; Alzheimer's disease;
   Emisymmetric bilateral stimulation
ID TRANSCRANIAL MAGNETIC STIMULATION; NONINVASIVE BRAIN-STIMULATION;
   MINI-MENTAL-STATE; NORMATIVE DATA; RELIABILITY; PERFORMANCE; STRENGTH;
   BATTERY
AB Background and aims: In the last decade, the development of different methods of brain stimulation by electromagnetic fields (EMF) provides a promising therapeutic tool for subjects with impaired cognitive functions. Emisymmetric bilateral stimulation (EBS) is a novel and innovative EMF brain stimulation, whose working principle is to introduce very weak noise-like stimuli through EMF to trigger self-arrangements in the cortex of treated subjects, thereby improving cognitive faculties. The aim of this pilot study was to investigate in patients with cognitive impairment the effectiveness of EBS treatment with respect to global cognitive function, episodic memory, and executive functions.
   Methods: Fourteen patients with cognitive decline (six with mild cognitive impairment and eight with Alzheimer's disease) underwent three EBS applications per week to both the cerebral cortex and auricular-specific sites for a total of 5 weeks. At baseline, after 2 weeks and 5 weeks, a neuropsychological assessment was performed through mini-mental state examination, free and cued selective reminding tests, and trail making test. As secondary outcomes, changes in behavior, functionality, and quality of life were also evaluated.
   Results: After 5 weeks of standardized EBS therapy, significant improvements were observed in all neurocognitive assessments. Mini-mental state examination score significantly increased from baseline to end treatment (+3.19, P=0.002). Assessment of episodic memory showed an improvement both in immediate and delayed recalls (immediate recall =+7.57, P=0.003; delayed recall =+4.78, P<0.001). Executive functions significantly improved from baseline to end stimulation (trail making test A -53.35 seconds; P=0.001). Of note, behavioral disorders assessed through neuropsychiatric inventory significantly decreased (-28.78, P<0.001). The analysis concerning the Alzheimer's disease and mild cognitive impairment group confirmed a significant improvement of cognitive functions and behavior after EBS treatment.
   Conclusion: This pilot study has shown EBS to be a promising, effective, and safe tool to treat cognitive impairment, in addition to the drugs presently available. Further investigations and controlled clinical trials are warranted.
C1 [Guerriero, Fabio; Sgarlata, Carmelo; Ricevuti, Giovanni; Francis, Matthew] Univ Pavia, Dept Internal Med & Med Therapy, Sect Geriatr, I-27100 Pavia, Italy.
   [Guerriero, Fabio; Rollone, Marco; Ricevuti, Giovanni; Guido, Davide] Santa Margherita Hosp, Agcy Elderly People Serv, Pavia, Italy.
   [Guerriero, Fabio; Botarelli, Emanuele; Mele, Gianni; Polo, Lorenzo; Zoncu, Daniele; Renati, Paolo; Mannu, Piero] Ambra Elektron, Italian Assoc Biophys Study Electromagnet Fields, Turin, Italy.
   [Renati, Paolo] Alberto Sorti Res Inst, Med & Metamol Biol, Turin, Italy.
   [Rondanelli, Mariangela; Perna, Simone] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Sect Human Nutr, Endocrinol & Nutr Unit, I-27100 Pavia, Italy.
   [Guido, Davide] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Biostat & Clin Epidemiol Unit, I-27100 Pavia, Italy.
C3 University of Pavia; University of Pavia; University of Pavia
RP Guerriero, F (corresponding author), Univ Pavia, Dept Internal Med & Med Therapy, Sect Geriatr, Via Emilia 12, I-27100 Pavia, Italy.
EM fabio_guerriero@yahoo.it
RI Perna, Simone/Y-8892-2018; Mannu, Piero/AAM-5396-2020; Rondanelli,
   Mariangela/AGD-6274-2022; Guerriero, Fabio/L-6393-2016; Ricevuti,
   Giovanni/AAK-7707-2021
OI Perna, Simone/0000-0002-2720-1473; Guerriero, Fabio/0000-0002-9926-2494;
   Ricevuti, Giovanni/0000-0003-3422-2747; Guido,
   Davide/0000-0002-3291-3686; Sgarlata, Carmelo/0000-0002-2667-4455
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U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2015
VL 11
BP 2391
EP 2404
DI 10.2147/NDT.S90966
PG 14
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA CS7YP
UT WOS:000362303200001
PM 26425094
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Casten, R
   Leiby, BE
   Kelley, M
   Rovner, BW
AF Casten, Robin
   Leiby, Benjamin E.
   Kelley, Megan
   Rovner, Barry W.
TI A randomized controlled trial to test the efficacy of a diabetes
   behavioral intervention to prevent memory decline in older
   blacks/African Americans with diabetes and mild cognitive impairment
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Dementia; Alzheimer?s disease; Diabetes; Health disparities
ID ALZHEIMERS ASSOCIATION WORKGROUPS; COHERENCE TOMOGRAPHY ANGIOGRAPHY;
   APOLIPOPROTEIN-E EPSILON-4; STRUCTURAL BRAIN CHANGES; VERBAL-LEARNING
   TEST; AFRICAN-AMERICANS; DIAGNOSTIC GUIDELINES; DEMENTIA PREVENTION;
   NATIONAL INSTITUTE; LONGITUDINAL DATA
AB Background: The prevalence of dementia in Blacks/African Americans (AAs) is almost twice that of Whites. In-equities in access to health care, socioeconomic conditions, and diabetes contribute to this disparity. Poorly controlled diabetes, which is more prevalent in Blacks/AAs, causes microvascular disease and neurodegeneration and increases dementia risk. Improving glycemic control, therefore, may prevent cognitive decline. To address this issue, we developed Diabetes Regulation for Eyesight and Memory (DREAM), a community health worker (CHW)-led behavioral intervention to improve diabetes self-management and thereby prevent cognitive decline. DREAM consists of home-based diabetes education, goal setting, and telehealth visits with a diabetes nurse educator. Exploratory aims will investigate whether APOE genotype moderates and retinal biomarkers mediate treatment effects. This report describes the trial's rationale, methodology, and study procedures. (clinicaltrials. gov identifier NCT04259047).Methods: This randomized controlled trial will test the efficacy of DREAM to prevent decline in memory (primary outcome) in Blacks/AAs aged 65+ with poorly controlled diabetes and Mild Cognitive Impairment (MCI). Two hundred participants will be randomized to DREAM or an attention control condition, and will receive 11 in -home treatment sessions over two years. Outcome data are collected at 6, 12, 18, and 24 months. The pri-mary outcome is verbal learning as measured by Hopkins Verbal Learning Test (HVLT) Total Recall scores. Participants will have retinal imaging at baseline, 12, and 24 months.Conclusions: This research aims to prevent cognitive decline in older Blacks/AAs with diabetes and MCI. If successful, this research will preserve health in an underserved population and reduce racial health disparities.
C1 [Casten, Robin] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Psychiat & Human Behav, 1015 Walnut St,Suite 709, Philadelphia, PA 19107 USA.
   [Leiby, Benjamin E.] Thomas Jefferson Univ, Dept Pharmacol Physiol & Canc Biol, Div Biostat, Kimmel Med Coll, 130 S 19 th St, 17 th Floor, Philadelphia, PA 19107 USA.
   [Kelley, Megan] Thomas Jefferson Univ, Dept Neurol, Sidney Kimmel Med Coll, 1015,Walnut St,Suite 709, Philadelphia, PA 19107 USA.
   [Rovner, Barry W.] Thomas Jefferson Univ, Dept Neurol Psychiat & Ophthalmol, Sidney Kimmel Med Coll, 900 Walnut St, Philadelphia, PA 19107 USA.
C3 Jefferson University; Jefferson University; Jefferson University;
   Jefferson University
RP Casten, R (corresponding author), Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Psychiat & Human Behav, 1015 Walnut St,Suite 709, Philadelphia, PA 19107 USA.
EM Robin.Casten@Jefferson.edu; Benjamin.Leiby@Jefferson.edu;
   Megan.Kelley@Jefferson.edu; Barry.Rovner@jefferson.edu
FU National Institute on Aging;  [R01AG065467]
FX Acknowledgements This study is funded by the National Institute on Aging
   (R01AG065467) . The sponsor had no role in the study design, data
   collection, in the analysis and interpretation of data, in the writing
   of this manuscript, or the decision to submit this manuscript for
   publication.
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NR 77
TC 1
Z9 1
U1 2
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD DEC
PY 2022
VL 123
AR 106977
DI 10.1016/j.cct.2022.106977
EA NOV 2022
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 6C6TN
UT WOS:000882144100002
PM 36341847
DA 2023-08-17
ER

PT J
AU Wu, VX
   Chi, YC
   Lee, JK
   Goh, HS
   Chen, DYM
   Haugan, G
   Chao, FFT
   Klainin-Yobas, P
AF Wu, Vivien Xi
   Chi, Yuchen
   Lee, Jeong Kyu
   Goh, Hongli Sam
   Chen, Delphine Yu Mei
   Haugan, Gorill
   Chao, Felicia Fang Ting
   Klainin-Yobas, Piyanee
TI The effect of dance interventions on cognition, neuroplasticity,
   physical function, depression, and quality of life for older adults with
   mild cognitive impairment: A systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Review
DE Dance intervention; Older adults; Mild cognitive impairment; Cognition;
   Neuroplasticity; Physical function; Quality of life; Depression; Memory;
   Visuospatial function
ID MINI-MENTAL-STATE; HEALTH SURVEY; EXERCISE; MCI; DEMENTIA; PROGRESSION;
   OUTCOMES; THERAPY; DISEASE; RISK
AB Background: Mild cognitive impairment is an age-related cognitive disorder which is associated with fre-quent memory lapses, impaired judgement, and progressive functional decline. If untreated early, 39.2% of people with mild cognitive impairment could progress to develop dementia. However, there are currently no approved pharmacological interventions to treat the condition, which lead researchers to explore non-pharmacological options, such as dance therapy. Objectives: This systematic review aimed to examine the effectiveness of dance interventions on cogni-tion, neuroplasticity, physical function, depression, and quality of life in older adults with mild cognitive impairment. Methods: Seven databases were systematically searched from their respective inception dates to 31 March 2020. Relevant randomized controlled trials (RCTs) were screened and assessed for risk of bias. Eight RCTs evaluating dance interventions were included. Results: Results showed that dance interventions had a significant moderate effect on global cognition (SMD = 0.54, Z = 3.55, p < 0.001), significantly improved memory (SMD = 0.33, Z = 3.97, p < 0.001), visu-ospatial function (SMD = 0.42, Z = 2.41, p = 0.02), and language (SMD = 0.39, Z = 2.69, p = 0.007). We found that dance interventions produced a significant moderate effect on physical function (SMD = 0.55, Z = 3.43, p < 0.001), and a significant effect on quality of life (SMD = 0.93, Z = 5.04, p < 0.0.001). Conclusion: Dance is a non-pharmacological and inexpensive intervention that can be implemented for older adults on a large scale. It can slow down the cognitive deterioration of older adults with mild cognitive impairment. However, the findings should be interpreted with caution due to the heterogene -ity in intervention designs. Rigorous design studies with long-term follow-ups, neuroimaging, biological markers, and comprehensive neuropsychological assessment are required to understand the mechanism of dance interventions and demonstrate its efficacy for older adults with mild cognitive impairment. The protocol was registered on PROSPERO (CRD42020173659). (c) 2021 Elsevier Ltd. All rights reserved.
C1 [Wu, Vivien Xi; Chi, Yuchen; Goh, Hongli Sam; Chao, Felicia Fang Ting; Klainin-Yobas, Piyanee] Natl Univ Singapore, Yong Loo Lin Sch Med, Alice Lee Ctr Nursing Studies, Clin Res Ctr, Level 2,Block MD 11,10 Med Dr, Singapore 117597, Singapore.
   [Lee, Jeong Kyu] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Tahir Fdn Bldg,12 Sci Dr 2,09-01Y, Singapore 117549, Singapore.
   [Lee, Jeong Kyu] Natl Univ Hlth Syst, Tahir Fdn Bldg,12 Sci Dr 2,09-01Y, Singapore 117549, Singapore.
   [Chen, Delphine Yu Mei] Tan Tock Seng Hosp, Gen Med, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
   [Haugan, Gorill] Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, Postbox 8905, N-7491 Trondheim, Norway.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; Tan Tock Seng Hospital; Norwegian
   University of Science & Technology (NTNU)
RP Wu, VX (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Alice Lee Ctr Nursing Studies, Clin Res Ctr, Level 2,Block MD 11,10 Med Dr, Singapore 117597, Singapore.
EM nurwux@nus.edu.sg; sirius.chi.ly@gmail.com; ephljk@nus.edu.sg;
   nurgoh@nus.edu.sg; yu_mei_chen@ttsh.com.sg; gorill.haugan@ntnu.no;
   chaofeliciaft.fc@gmail.com; nurpk@nus.edu.sg
RI Goh, Hongli Sam/AAC-9338-2022
OI Chao, Felicia Fang Ting/0000-0002-2184-0936; WU, Xi
   Vivien/0000-0002-9264-3630
FU National University of Singapore Start Up Grant
   [NUHSRO/2019/081/Startup/06]
FX This research is supported by funding from National University of
   Singapore Start Up Grant (NUHSRO/2019/081/Startup/06).
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NR 81
TC 17
Z9 17
U1 15
U2 48
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD OCT
PY 2021
VL 122
AR 104025
DI 10.1016/j.ijnurstu.2021.104025
EA JUL 2021
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA UR7NK
UT WOS:000696931100018
PM 34298320
DA 2023-08-17
ER

PT J
AU Schmitter-Edgecombe, M
   Dyck, DG
AF Schmitter-Edgecombe, Maureen
   Dyck, Dennis G.
TI Cognitive Rehabilitation Multi-family Group Intervention for Individuals
   with Mild Cognitive Impairment and Their Care-Partners
SO JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
LA English
DT Article
DE Non-pharmacological interventions; Randomized controlled trial; Memory;
   Compensatory strategies; Cognitive training; Caregivers
ID RANDOMIZED CONTROLLED-TRIAL; FAMILY GROUP TREATMENT; HEALTHY
   OLDER-ADULTS; ALZHEIMERS-DISEASE; MEMORY; DEMENTIA; SCHIZOPHRENIA;
   VALIDITY; RISK; RELIABILITY
AB There is increasing need for early, pro-active programs that can delay dementia diagnosis and enhance well-being of individuals with mild cognitive impairment (MCI) and their care-partners (i.e., care-dyads). This randomized controlled trial evaluated the efficacy of a combined cognitive rehabilitation and multi-family group treatment (CR-MFG) that was designed to facilitate adoption of newly learned cognitive strategies into the care-dyads everyday lives. Analyzed data included 23 care-dyads who participated in CR-MFG treatment and 23 care-dyads in standard care (SC). The 3-month intervention consisted of individual joining sessions, an educational workshop, and 20/twice weekly multifamily memory strategy training and problem-solving sessions. Everyday functioning, memory, and psychological functioning (i.e., quality-of-life, depression, coping) were assessed. The CR-MFG intervention was associated with significant post-test group differences and improved post-test performances by the MCI participants on performance-based measures of everyday functioning and neuropsychological tests of memory. There was also some suggestion that CR-MFG care-partners perceived positive change in the everyday functioning of the MCI participants. In contrast, no post-test group differences were found for either care-dyad member on the self-report psychological measures; care-partners in the treatment group did self-report improved coping behaviors at post-test. These 3-month results are preliminary but suggestive that CR-MFG may produce modest, practical everyday functional benefits for persons with MCI.
C1 [Schmitter-Edgecombe, Maureen] Washington State Univ, Dept Psychol, Pullman, WA 99164 USA.
   [Dyck, Dennis G.] Washington State Univ, Dept Psychol, Spokane, WA USA.
C3 Washington State University; Washington State University
RP Schmitter-Edgecombe, M (corresponding author), Washington State Univ, Dept Psychol, POB 644820, Pullman, WA 99164 USA.
EM schmitter-e@wsu.edu
FU Alzheimer's Association [NPSASA-10-173354]
FX This study was supported by a grant from the Alzheimer's Association
   (grant number NPSASA-10-173354). No conflicts of interest exist. We
   thank Chad Sanders, Christina Low, and Diane Norell for their assistance
   in treatment development and implementation. We thank Lauren Warren,
   Rachael Jones, Kaci Johnson, and Jennifer Walker for their assistance in
   coordinating data collection. We thank the many WSU doctoral students in
   Clinical Psychology and community professionals who assisted in
   development of the workbook materials, tested participants and served as
   therapists for the groups. We also thank members of the WSU Cognitive
   Aging and Dementia laboratory for their help in coding the data and data
   entry.
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NR 49
TC 43
Z9 45
U1 1
U2 30
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1355-6177
EI 1469-7661
J9 J INT NEUROPSYCH SOC
JI J. Int. Neuropsychol. Soc.
PD OCT
PY 2014
VL 20
IS 9
BP 897
EP 908
DI 10.1017/S1355617714000782
PG 12
WC Clinical Neurology; Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA AT4YD
UT WOS:000344947600003
PM 25222630
DA 2023-08-17
ER

PT J
AU Wenisch, E
   Cantegreil-Kallen, I
   De Rotrou, J
   Garrigue, P
   Moulin, F
   Batouche, F
   Richard, A
   De Sant'Anna, M
   Rigaud, AS
AF Wenisch, Emilie
   Cantegreil-Kallen, Inge
   De Rotrou, Jocelyne
   Garrigue, Pia
   Moulin, Florence
   Batouche, Feriel
   Richard, Aurore
   De Sant'Anna, Martha
   Rigaud, Anne Sophie
TI Cognitive stimulation intervention for elders with mild cognitive
   impairment compared to normal aged subjects: preliminary results
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 18th World Congress of the International-Association-of-Gerontology
CY JUN 26-30, 2005
CL Rio de Janeiro, BRAZIL
SP Int Assoc Gerontol
DE cognitive reserve; cognitive stimulation intervention; mild cognitive
   impairment; prevention
ID RANDOMIZED CONTROLLED-TRIAL; ALZHEIMERS-DISEASE; OLDER-ADULTS; DEMENTIA;
   RESERVE; MCI; CONVERSION; EDUCATION; CRITERIA; DECLINE
AB Background and aims: Cognitive training programs have been developed for Alzheimer's disease patients and the healthy elderly population. Collective cognitive stimulation programs have been shown to be efficient for subjects with memory complaint, The aim of this study was to evaluate the benefit of such cognitive programs in populations with Mild Cognitive Impairment (MCI).
   Methods: Twelve patients with MCI and twelve cognitively normal elders were administered a cognitive stimulation program. Cognitive performance (Logical Memory, Word paired associative learning task, Trail Making Test, verbal fluency test) were collected before and after the intervention. A gain score [(post-score-prescore)/pre-score] was calculated for each variable and compared between groups.
   Results: The analysis revealed a larger intervention size effect in MCI than in normal elders' performances on the associative learning task (immediate recall: p < 0.05, delayed recall: p < 0.01). The intervention was more beneficial in improving associative memory abilities in MCI than in normal subjects. At the end of the intervention, the MCI group had lower results than the normal group only for the delayed recall of Logical Memory.
   Conclusions: Although further studies are needed for more details on the impact of cognitive stimulation programs on MCI patients, this intervention is effective in compensating associative memory difficulties of these patients. Among non-pharmacological interventions, cognitive stimulation therapy is a repeatable and inexpensive collective method that can easily be provided to various populations with the aim of slowing down the rate of decline in elderly persons with cognitive impairment.
C1 Broca Hosp, Dept Gerontol, F-75013 Paris, France.
C3 UDICE-French Research Universities; Universite Paris Cite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Broca - APHP
RP Wenisch, E (corresponding author), Broca Hosp, Dept Gerontol, 54-56 Rue Pascal, F-75013 Paris, France.
EM emilie.wenisch@brc.aphp.fr
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NR 35
TC 68
Z9 71
U1 4
U2 44
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD AUG
PY 2007
VL 19
IS 4
BP 316
EP 322
DI 10.1007/BF03324708
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Geriatrics & Gerontology
GA 212IN
UT WOS:000249590000010
PM 17726363
DA 2023-08-17
ER

PT J
AU Bittner, DM
   Bittner, V
   Hausmann, J
   Reinhold, D
   Machts, J
   Westphal, S
   Heinze, HJ
   Schott, B
   Kaufmann, J
   Muller, NJ
AF Bittner, D. M.
   Bittner, V
   Hausmann, J.
   Reinhold, D.
   Machts, J.
   Westphal, S.
   Heinze, H. -J
   Schott, B.
   Kaufmann, J.
   Mueller, N. J.
TI Training Intervention Improves Memory in Mild Cognitive Impairment and
   Healthy Controls, but Plasma BDNF Acts Differentially
SO JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
C1 [Bittner, D. M.; Bittner, V; Hausmann, J.; Machts, J.; Heinze, H. -J; Kaufmann, J.] Univ Magdeburg, Dept Neurol, D-39106 Magdeburg, Germany.
   [Reinhold, D.] Univ Magdeburg, Inst Mol & Clin Immunol, D-39106 Magdeburg, Germany.
   [Westphal, S.] Univ Magdeburg, Inst Clin Chem & Biochem, D-39106 Magdeburg, Germany.
   [Heinze, H. -J; Mueller, N. J.] German Ctr Neurodegenerat Dis DZNE, Munich, Germany.
   [Schott, B.] Charite, Dep Psychiat, Berlin, Germany.
C3 Otto von Guericke University; Otto von Guericke University; Otto von
   Guericke University; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE); Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RI Schott, Björn H/U-5626-2017
OI Schott, Björn H/0000-0002-8237-4481
NR 0
TC 3
Z9 3
U1 0
U2 5
PU HOGREFE & HUBER PUBLISHERS
PI GOTTINGEN
PA ROHNSWEG 25, D-37085 GOTTINGEN, GERMANY
SN 0269-8803
J9 J PSYCHOPHYSIOL
JI J. Psychophysiol.
PY 2013
VL 27
SU 1
BP 49
EP 50
PG 2
WC Psychology, Biological; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA 130ZI
UT WOS:000317959400108
DA 2023-08-17
ER

PT J
AU Denboer, J
AF Denboer, J.
TI Strategic Memory Alzheimers Rehabilitation Training (SMART): Cognitive
   Protection and Intervention for Amnestic-type Mild Cognitive Impairment
   (MCI)
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PY 2017
VL 31
IS 4
MA 22
BP 718
EP 718
PG 1
WC Psychology, Clinical; Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA ES6HB
UT WOS:000399646200062
DA 2023-08-17
ER

PT J
AU Mattos, MK
   Manning, CA
   Quigg, M
   Davis, EM
   Barnes, L
   Sollinger, A
   Eckstein, M
   Ritterband, LM
AF Mattos, Meghan K.
   Manning, Carol A.
   Quigg, Mark
   Davis, Eric M.
   Barnes, Laura
   Sollinger, Ann
   Eckstein, Michelle
   Ritterband, Lee M.
TI Feasibility and Preliminary Efficacy of an Internet-Delivered
   Intervention for Insomnia in Individuals with Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Aged; behavioral intervention; cognitive dysfunction; insomnia;
   Internet; mild cognitive impairment; research
ID SEVERITY INDEX; SLEEP; PREVALENCE; VALIDATION; THERAPY
AB Background: Approximately 50% of older adults with cognitive impairment suffer from insomnia. When untreated, preexisting cognitive problems may be exacerbated and potentially contribute to further cognitive decline. One promising approach to maintain cognitive health is to improve sleep quantity and quality.
   Objective: To determine feasibility, acceptability, and preliminary efficacy of Sleep Health Using the Internet for Older Adult Sufferers of Insomnia and Sleeplessness (SHUTi OASIS), an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) program in older adults with mild cognitive impairment (MCI).
   Methods: Older adults with MCI and insomnia were recruited from hospital-based memory and sleep disorders clinics and enrolled in a single-arm pilot study. Participants completed the six cores of SHUTi OASIS, over nine weeks with two-week baseline and post-assessments using self-reported sleep diaries. Feasibility and acceptability were informed by usage statistics and qualitative interviews; preliminary efficacy was informed by patient-generated sleep data.
   Results: Twelve participants enrolled and, on average, were 75.8 years of age. Ten participants completed the study and logged in most days. Most participants reported a positive overall experience, and interviews revealed successful and independent program management and completion. There were significant changes on all baseline to post-assessment sleep measures, including clinically meaningful improvements on the Insomnia Severity Index (13.5 to 8.3, p < 0.01), sleep efficiency, wake after sleep onset, and sleep onset latency (ps < 0.02). There was no statistically significant change in cognitive measures (p > 0.05).
   Conclusion: This study supports that older adults with cognitive impairment can independently complete CBT-I via the Internet and achieve clinical sleep improvements.
C1 [Mattos, Meghan K.; Manning, Carol A.] Univ Virginia, Sch Nursing, Charlottesville, VA 22903 USA.
   [Manning, Carol A.; Quigg, Mark; Davis, Eric M.; Ritterband, Lee M.] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA.
   [Barnes, Laura] Univ Virginia, Sch Engn & Appl Sci, Charlottesville, VA USA.
   [Sollinger, Ann] Virginia Tech Carilion, Sch Med, Roanoke, VA USA.
   [Eckstein, Michelle] MedStar Georgetown Univ Hosp, Washington, DC USA.
C3 University of Virginia; University of Virginia; University of Virginia;
   Georgetown University
RP Mattos, MK (corresponding author), Univ Virginia, Sch Nursing, Acute & Specialty Care, McLeod Hall Room 5012,POB 800782, Charlottesville, VA 22903 USA.
EM ms2bv@virginia.edu
RI Ritterband, Lee M/G-7810-2011
OI Ritterband, Lee M/0000-0001-7624-5213; Quigg, Mark/0000-0003-3035-9260
FU National Center for Advancing Translational Sciences of the National
   Institutes of Health [UL1TR003015, KL2TR003016]; National Institute of
   Aging [5R01AG047885]
FX This work is supported in part by the National Center for Advancing
   Translational Sciences of the National Institutes of Health under Award
   Numbers UL1TR003015 and KL2TR003016; National Institute of Aging
   5R01AG047885 (PI: Ritterband). The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the National Institutes of Health. We want to acknowledge Christina
   Frederick, Jacqueline Le, Gabriel Heath, and the rest of the UVA Center
   for Behavioral Health and Technology team for their significant
   contributions to this study. We also want to recognize Reanna Panagides
   for her contributions to the qualitative analysis for this work.
CR Alzheimer's Society, 2014, DEMENTIA UK
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NR 39
TC 2
Z9 2
U1 4
U2 10
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2021
VL 84
IS 4
BP 1539
EP 1550
DI 10.3233/JAD-210657
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA XL4BT
UT WOS:000728091100014
PM 34690141
DA 2023-08-17
ER

PT J
AU Lydon, EA
   Nguyen, LT
   Nie, Q
   Rogers, WA
   Mudar, RA
AF Lydon, Elizabeth A.
   Nguyen, Lydia T.
   Nie, Qiong
   Rogers, Wendy A.
   Mudar, Raksha A.
TI An Integrative Framework to Guide Social Engagement Interventions and
   Technology Design for Persons With Mild Cognitive Impairment
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE mild cognitive impairment; social engagement; social isolation;
   loneliness; technology; social activity; social network
ID OLDER-ADULTS; LATE-LIFE; LONELINESS; HEALTH; NETWORK; RISK;
   PARTICIPATION; METAANALYSIS; DEMENTIA; RESERVE
AB Social isolation and loneliness in older adults are associated with poor health outcomes and have been linked to an increased risk of cognitive impairment and incident dementia. Social engagement has been identified as a key factor in promoting positive health behaviors and quality of life and preventing social isolation and loneliness. Studies involving cognitively healthy older adults have shown the protective effects of both in-person and technology-based social engagement. However, the benefits of social engagement for people who are already at-risk of developing dementia, namely those with mild cognitive impairment (MCI), have yet to be elucidated. We present a narrative review of the literature, summarizing the research on social engagement in MCI. First, we identified social networks (quality, size, frequency, and closeness) and social activities (frequency, format, purpose, type, and content) as two overarching dimensions of an integrative framework for social engagement derived from literature examining typical cognitive aging. We then used this framework as a lens to examine studies of social engagement in MCI to explore (i) the relationship between in-person and technology-based social engagement and cognitive, emotional, and physical health, and (ii) interventions that target social engagement including technology-based approaches. Overall, we found that persons with MCI (PwMCI) may have different levels of social engagement than those experiencing typical cognitive aging. Moreover, in-person social engagement can have a positive impact on cognitive, emotional, and physical health for PwMCI. With respect to activity and network dimensions in our framework, we found that cognitive health has been more widely examined in PwMCI relative to physical and emotional health. Very few intervention studies have targeted social engagement, but both in-person and technology-based interventions appear to have promising health and well-being outcomes. Our multidimensional framework of social engagement provides guidance for research on characterizing the protective benefits of social engagement for PwMCI and informs the development of novel interventions including technology-based approaches.
C1 [Lydon, Elizabeth A.; Mudar, Raksha A.] Univ Illinois, Dept Speech & Hearing Sci, Champaign, IL 61820 USA.
   [Nguyen, Lydia T.] iN2L, Greenwood Village, CO USA.
   [Nie, Qiong; Rogers, Wendy A.] Univ Illinois, Dept Kinesiol & Community Hlth, Champaign, IL USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign
RP Mudar, RA (corresponding author), Univ Illinois, Dept Speech & Hearing Sci, Champaign, IL 61820 USA.
EM raksha@illinois.edu
RI Nguyen, Lydia/GSN-2623-2022
OI Nguyen, Lydia/0000-0002-9023-7081
FU National Institutes of Health (National Institute on Aging) [R44
   AG059450]; MCI through Social Engagement over Video Technology; National
   Institute on Disability, Independent Living, and Rehabilitation Research
   (NIDILRR) [90REGE0012]; Rehabilitation and Engineering Research Center
   on Enhancing Neurocognitive Health, Abilities, Networks, and Community
   Engagement (ENHANCE)
FX This research was supported in part by the National Institutes of Health
   (National Institute on Aging) Grant R44 AG059450, entitled Enhancing
   Quality of Life for Older Adults with and without MCI through Social
   Engagement over Video Technology, as well as by a grant from the
   National Institute on Disability, Independent Living, and Rehabilitation
   Research (NIDILRR Grant Number 90REGE0012) under the auspices of the
   Rehabilitation and Engineering Research Center on Enhancing
   Neurocognitive Health, Abilities, Networks, and Community Engagement
   (ENHANCE; www.enhance-rerc.org).
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NR 77
TC 3
Z9 3
U1 2
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JAN 14
PY 2022
VL 9
AR 750340
DI 10.3389/fpubh.2021.750340
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA YO8BS
UT WOS:000748160300001
PM 35096730
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Costanzo, MC
   Arcidiacono, C
   Rodolico, A
   Panebianco, M
   Aguglia, E
   Signorelli, MS
AF Costanzo, Maria Cristina
   Arcidiacono, Chiara
   Rodolico, Alessandro
   Panebianco, Mariangela
   Aguglia, Eugenio
   Signorelli, Maria Salvina
TI Diagnostic and interventional implications of telemedicine in
   Alzheimer's disease and mild cognitive impairment: A literature review
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE Alzheimer disease; smartphone; tablet; technology; telemedicine
ID VERBAL-INSTRUCTION TECHNOLOGY; CAREGIVER BURDEN; FAMILY CAREGIVERS;
   TRACKING TECHNOLOGY; SPOUSAL CAREGIVERS; MODERATE; DEMENTIA; PEOPLE;
   SUPPORT; HEALTH
AB Introduction Worldwide, life expectancy, and aging-related disorders as mild cognitive impairment (MCI) and Alzheimer disease (AD) are increasing, having a rising impact on patients' quality of life and caregivers' distress. Telemedicine offers many possibilities, such as remote diagnosing and monitoring of patients. Objective The purpose of this study is to provide a narrative synthesis of the literature about the implementation of telemedicine for diagnosis, treatment, and follow-up of patients with AD and MCI and their caregivers. Methods A systematic literature review was conducted on MEDLINE, EMBASE, and the Cochrane Library databases up to September 2018. MCI or AD diagnoses were the conditions of interest. We excluded other dementias. Results Fifty-six articles met inclusion criteria. We identified two main categories: diagnosis group (DG) and follow-up/interventional group (FIG). Fifteen articles suggested how to make a remote or earlier diagnosis: four were case-control accuracy studies, nine were paired comparative accuracy studies, and two were prospective single-arm accuracy studies. Among these, four focused on MCI, six on AD, and five on both. Forty one focused on supporting patients during the stages of the disease (28 articles), patient's caregivers (nine articles), or both (four articles). Conclusions The rising use of telemedicine could actively improve AD and MCI patients' lives, reduce caregivers' burden, and facilitate an early diagnosis if patients live in remote places. However, as some studies report, it is relevant to take into account the emotional impact of telemedicine on patients and not only on the effectiveness.
C1 [Costanzo, Maria Cristina; Arcidiacono, Chiara; Rodolico, Alessandro; Aguglia, Eugenio; Signorelli, Maria Salvina] Univ Catania, Inst Psychiat, Dept Clin & Expt Med, Catania, Italy.
   [Panebianco, Mariangela] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England.
C3 University of Catania; N8 Research Partnership; University of Liverpool
RP Signorelli, MS (corresponding author), Univ Catania, Inst Psychiat, Via Santa Sofia 78, I-95121 Catania, Italy.
EM maria.signorelli@unict.it
RI Panebianco, Mariangela/AAB-8723-2022; Rodolico,
   Alessandro/GQQ-5888-2022; Signorelli, Maria/E-6155-2010; Signorelli,
   Maria Salvina/E-6155-2010
OI Rodolico, Alessandro/0000-0003-2196-0601; Signorelli,
   Maria/0000-0002-6941-9454; Signorelli, Maria
   Salvina/0000-0001-5835-4176; Panebianco, Mariangela/0000-0001-8956-5486
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NR 84
TC 34
Z9 35
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD JAN
PY 2020
VL 35
IS 1
BP 12
EP 28
DI 10.1002/gps.5219
EA NOV 2019
PG 17
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA QF1KN
UT WOS:000496552500001
PM 31617247
DA 2023-08-17
ER

PT J
AU Hickman, L
   Ferguson, C
   Davidson, PM
   Allida, S
   Inglis, S
   Parker, D
   Agar, M
AF Hickman, Louise
   Ferguson, Caleb
   Davidson, Patricia M.
   Allida, Sabine
   Inglis, Sally
   Parker, Deborah
   Agar, Meera
TI Key elements of interventions for heart failure patients with mild
   cognitive impairment or dementia: A systematic review
SO EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Review
DE Mild cognitive impairment; heart failure; dementia; nurse led
   interventions
ID SELF-CARE; MEMORY; ASSOCIATION; PERFORMANCE; MANAGEMENT; PROGRAM;
   SUPPORT; MCI
AB Background: The purpose of this systematic review was to (a) examine the effects of interventions delivered by a heart failure professional for mild cognitive impairment and dementia on cognitive function, memory, working memory, instrumental activities of daily living, heart failure knowledge, self-care, quality of life and depression; and (b) identify the successful elements of these strategies for heart failure patients with mild cognitive impairment or dementia. Methods and results: During March 2018, an electronic search of databases including CINAHL, MEDLINE, EMBASE and PsycINFO was conducted. All randomised controlled trials, which examined an intervention strategy to help heart failure patients with mild cognitive impairment or dementia cope with self-care, were included. An initial search yielded 1622 citations, six studies were included (N= 595 participants, mean age 68 years). There were no significant improvements in cognitive function and depression. However, significant improvements were seen in memory (p=0.015), working memory (p=0.029) and instrumental activities of daily living (p=0.006). Nurse led interventions improved the patient's heart failure knowledge (p=0.001), self-care (p<0.05) and quality of life (p=0.029). Key elements of these interventions include brain exercises, for example, syllable stacks, individualised assessment and customised education, personalised self-care schedule development, interactive problem-solving training on scenarios and association techniques to prompt self-care activities. Conclusions: Modest evidence for nurse led interventions among heart failure patients with mild cognitive impairment or dementia was identified. These results must be interpreted with caution in light of the limited number of available included studies.
C1 [Hickman, Louise; Allida, Sabine; Inglis, Sally; Parker, Deborah; Agar, Meera] Univ Technol Sydney, Level 7,235 Jones St, Sydney, NSW 2007, Australia.
   [Ferguson, Caleb] Western Sydney Univ, Penrith, NSW, Australia.
   [Davidson, Patricia M.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
   [Ferguson, Caleb] Western Sydney Local Hlth Dist, North Parramatta, NSW, Australia.
C3 University of Technology Sydney; Western Sydney University; Johns
   Hopkins University
RP Hickman, L (corresponding author), Univ Technol Sydney, Level 7,235 Jones St, Sydney, NSW 2007, Australia.
EM louise.hickman@uts.edu.au
RI Agar, Meera/AAI-4002-2021; Ferguson, Caleb/G-4972-2015; Parker,
   Deborah/B-1962-2009; Hickman, Louise D/AAV-1449-2020; Allida,
   Sabine/IAP-6917-2023
OI Agar, Meera/0000-0002-6756-6119; Ferguson, Caleb/0000-0002-2417-2216;
   Hickman, Louise D/0000-0002-5116-6559; Allida,
   Sabine/0000-0003-0161-8649; Davidson, Patricia M./0000-0003-2050-1534
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NR 30
TC 4
Z9 5
U1 3
U2 14
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1474-5151
EI 1873-1953
J9 EUR J CARDIOVASC NUR
JI Eur. J. Cardiovasc. Nurs.
PD JAN
PY 2020
VL 19
IS 1
BP 8
EP 19
AR 1474515119865755
DI 10.1177/1474515119865755
EA JUL 2019
PG 12
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA JX3OR
UT WOS:000479422100001
PM 31347402
OA Bronze
DA 2023-08-17
ER

PT J
AU Larouche, E
   Hudon, C
   Goulet, S
AF Larouche, Eddy
   Hudon, Carol
   Goulet, Sonia
TI Potential benefits of mindfulness-based interventions in mild cognitive
   impairment and Alzheimer's disease: An interdisciplinary perspective
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Mild cognitive impairment; Alzheimer's disease; Mindfulness-based
   intervention; Stress; Depression; Metabolic syndrome
ID WHITE-MATTER LESIONS; QUALITY-OF-LIFE; LEUKOCYTE TELOMERE LENGTH;
   GROWTH-FACTOR EXPRESSION; CORPUS-CALLOSUM ATROPHY; VOXEL-BASED
   MORPHOMETRY; BREAST-CANCER PATIENTS; CENTRAL-NERVOUS-SYSTEM; STRESS
   REDUCTION MBSR; VASCULAR RISK-FACTORS
AB The present article is based on the premise that the risk of developing Alzheimer's disease (AD) from its prodromal phase (mild cognitive impairment; MCI) is higher when adverse factors (e.g., stress, depression, and metabolic syndrome) are present and accumulate. Such factors augment the likelihood of hippocampal damage central in MCI/AD aetiology, as well as compensatory mechanisms failure triggering a switch toward neurodegeneration. Because of the devastating consequences of AD, there is a need for early interventions that can delay, perhaps prevent, the transition from MCI to AD. We hypothesize that mindfulness-based interventions (MBI) show promise with regard to this goal. The present review discusses the associations between modifiable adverse factors and MCI/AD decline, MBI's impacts on adverse factors, and the mechanisms that could underlie the benefits of MBI. A schematic model is proposed to illustrate the course of neurodegeneration specific to MCI/AD, as well as the possible preventive mechanisms of MBI. Whereas regulation of glucocorticosteroids, inflammation, and serotonin could mediate MBI's effects on stress and depression, resolution of the metabolic syndrome might happen through a reduction of inflammation and white matter hyperintensities, and normalization of insulin and oxidation. The literature reviewed in this paper suggests that the main reach of MBI over MCI/AD development involves the management of stress, depressive symptoms, and inflammation. Future research must focus on achieving deeper understanding of MBI's mechanisms of action in the context of MCI and AD. This necessitates bridging the gap between neuroscientific subfields and a cross-domain integration between basic and clinical knowledge. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Larouche, Eddy; Hudon, Carol; Goulet, Sonia] Univ Laval, Ecole Psychol, CRIUSMQ, Quebec City, PQ G1J 2G3, Canada.
C3 Laval University
RP Goulet, S (corresponding author), Univ Laval, Ecole Psychol, CRIUSMQ, 2601 Canardiere F-2400, Quebec City, PQ G1J 2G3, Canada.
EM sonia.goulet@psy.ulaval.ca
OI Hudon, Carol/0000-0002-7554-3187
FU Fonds de recherche du Quebec - Sante [26809]
FX The authors wish to thank Modesto R. Peralta III for text editing. C.
   Hudon is supported by a salary award (Chercheur-boursier Senior; No.
   26809) from the Fonds de recherche du Quebec - Sante.
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NR 231
TC 52
Z9 53
U1 1
U2 84
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JAN 1
PY 2015
VL 276
SI SI
BP 199
EP 212
DI 10.1016/j.bbr.2014.05.058
PG 14
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA AU2XP
UT WOS:000345478200022
PM 24893317
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Shandera-Ochsner, AL
   Chandler, MJ
   Locke, DE
   Ball, CT
   Crook, JE
   Phatak, VS
   Smith, GE
AF Shandera-Ochsner, Anne L.
   Chandler, Melanie J.
   Locke, Dona E.
   Ball, Colleen T.
   Crook, Julia E.
   Phatak, Vaishali S.
   Smith, Glenn E.
TI Comparative Effects of Physical Exercise and Other Behavioral
   Interventions on Functional Status Outcomes in Mild Cognitive Impairment
SO JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
LA English
DT Article
DE Yoga; Lifestyle; Quality of life; Neurodegenerative diseases; Activities
   of daily living; Cognitive dysfunction
ID ALZHEIMERS-DISEASE; OLDER-ADULTS; LIFE
AB Objectives: Lifestyle modifications for those with mild cognitive impairment (MCI) may promote functional stability, lesson disease severity, and improve well-being outcomes such as quality of life. The current analysis of our larger comparative effectiveness study evaluated which specific combinations of lifestyle modifications offered as part of the Mayo Clinic Healthy Action to Benefit Independence in Thinking (HABIT) program contributed to the least functional decline in people with MCI (pwMCI) over 18 months. Methods: We undertook to compare evidence-based interventions with one another rather than to a no-treatment control group. The interventions were five behavioral treatments: computerized cognitive training (CCT), yoga, Memory Support System (MSS) training, peer support group (SG), and wellness education (WE), each delivered to both pwMCI and care partners, in a group-based program. To compare interventions, we randomly withheld one of the five HABIT (R) interventions in each of the group sessions. We conducted 24 group sessions with between 8 and 20 pwMCI-partner dyads in a session. Results: Withholding yoga led to the greatest declines in functional ability as measured by the Functional Activities Questionnaire and Clinical Dementia Rating. In addition, memory compensation (calendar) training and cognitive exercise appeared to have associations (moderate effect sizes) with better functional outcomes. Withholding SG or WE appeared to have little effect on functioning at 18 months. Conclusions: Overall, these results add to the growing literature that physical exercise can play a significant and lasting role in modifying outcomes in a host of medical conditions, including neurodegenerative diseases.
C1 [Shandera-Ochsner, Anne L.] Mayo Clin Hlth Syst, Dept Psychiat & Psychol, 700 West Ave S, La Crosse, WI 54601 USA.
   [Chandler, Melanie J.] Mayo Clin, Dept Psychiat & Psychol, 4500 San Pablo Rd S, Jacksonville, FL 32224 USA.
   [Ball, Colleen T.; Crook, Julia E.] Mayo Clin, Div Biomed Stat & Informat, 13400 East Shea Blvd, Scottsdale, AZ 85259 USA.
   [Locke, Dona E.] Mayo Clin, Div Psychol, 13400 East Shea Blvd, Scottsdale, AZ 85259 USA.
   [Phatak, Vaishali S.] Univ Nebraska Med Ctr, Dept Neurol Sci, 42nd & Emile, Omaha, NE 68198 USA.
   [Smith, Glenn E.] Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic Phoenix; Mayo Clinic; Mayo Clinic
   Phoenix; University of Nebraska System; University of Nebraska Medical
   Center; State University System of Florida; University of Florida
RP Smith, GE (corresponding author), Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
EM glennsmith@phhp.ufl.edu
FU Patient-Centered Outcomes Research Institute (PCORI) Award
   [CER-130601897]
FX The institutions that employ the authors generate revenue from the HABIT
   clinical programs; the authors do not derive any direct financial
   benefit. Research reported in this manuscript was partially funded
   through a Patient-Centered Outcomes Research Institute (PCORI) Award
   (CER-130601897). The statements in this publication are solely the
   responsibility of the authors and do not necessarily represent the views
   of the PCORI, its Board of Governors, or Methodology Committee.
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NR 32
TC 3
Z9 3
U1 2
U2 6
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1355-6177
EI 1469-7661
J9 J INT NEUROPSYCH SOC
JI J. Int. Neuropsychol. Soc.
PD SEP
PY 2021
VL 27
IS 8
BP 805
EP 812
DI 10.1017/S1355617721000485
PG 8
WC Clinical Neurology; Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA UT9OA
UT WOS:000698436000007
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Bier, N
   Grenier, S
   Brodeur, C
   Gauthier, S
   Gilbert, B
   Hudon, C
   Lepage, E
   Ouellet, MC
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   Belleville, S
AF Bier, Nathalie
   Grenier, Sebastien
   Brodeur, Catherine
   Gauthier, Serge
   Gilbert, Brigitte
   Hudon, Carol
   Lepage, Emilie
   Ouellet, Marie-Christine
   Viscogliosi, Chantal
   Belleville, Sylvie
TI Measuring the impact of cognitive and psychosocial interventions in
   persons with mild cognitive impairment with a randomized single-blind
   controlled trial: rationale and design of the MEMO plus study
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE mild cognitive impairment; cognitive training; psychosocial
   intervention; randomized clinical trial; memory; psychosocial aspects;
   neuropsychological testing
ID GENERALIZED ANXIETY DISORDER; FREE-RECALL PERFORMANCE; HEALTHY
   OLDER-ADULTS; ALZHEIMERS-DISEASE; BEHAVIORAL TREATMENT; ANTIDEPRESSANT
   MEDICATION; INSTRUMENTAL ACTIVITIES; PSYCHOMETRIC PROPERTIES;
   REHABILITATION PROGRAM; ATTENTIONAL CONTROL
AB Background: Several studies have suggested that cognitive training is a potentially effective way to improve cognition and postpone cognitive decline in older adults with mild cognitive impairment (MCI). The MEMO+ study is a randomized, controlled, single-blind trial designed to test the efficacy, specificity, and long-term effect of a cognitive training intervention and a psychosocial intervention in persons with MCI.
   Methods: One hundred and sixty-two participants with MCI will be recruited. They will be randomized into three groups: cognitive training, psychosocial intervention, and no-contact. Each intervention will last for eight weeks (one session per week) and a booster training session will be provided three months after the end of the intervention. Various proximal and distal outcomes will be measured at pre-intervention as well as at one week, three months, and six months post-training. Proximal outcomes include memory and psychological health measures. Distal outcomes focus on self-rated functioning in complex daily activities and strategies used in daily life to enhance function. Socio-demographic factors (age, gender, and education), general cognition, personality traits, engagement in activities, and self-efficacy will be used as moderators. Enrolment began in April 2012 and will be completed by December 2014.
   Conclusions: This study is likely to have a significant impact on the well-being of persons with MCI by contributing to the development of adapted and scientifically supported cognitive and psychosocial interventions.
C1 [Bier, Nathalie; Grenier, Sebastien; Gilbert, Brigitte; Lepage, Emilie; Belleville, Sylvie] Inst Univ Geriatrie Montreal, Ctr Rech, Montreal, PQ H3W 1W4, Canada.
   [Bier, Nathalie] Univ Montreal, Ecole Readaptat, Montreal, PQ H3C 3J7, Canada.
   [Brodeur, Catherine] McGill Hlth Ctr, Montreal, PQ H3G 1A4, Canada.
   [Brodeur, Catherine; Gauthier, Serge] McGill Univ, Fac Med, Montreal, PQ H3G 1Y6, Canada.
   [Gauthier, Serge] McGill Ctr Studies Aging, Verdun, PQ H4H 1R2, Canada.
   [Hudon, Carol] Inst Univ Sante Mentale Quebec, Quebec City, PQ G1J 2G3, Canada.
   [Hudon, Carol; Ouellet, Marie-Christine] Univ Laval, Programme Psychol, Quebec City, PQ G1V 0A6, Canada.
   [Ouellet, Marie-Christine] Ctr Interdisciplinaire Rech Readaptat & Integrat, Quebec City, PQ G1M 2S8, Canada.
   [Viscogliosi, Chantal] Univ Sherbrooke, Programme Gerontol, Sherbrooke, PQ J1K 2R1, Canada.
   [Grenier, Sebastien; Belleville, Sylvie] Univ Montreal, Dept Psychol, Montreal, PQ H3C 3J7, Canada.
C3 Universite de Montreal; Universite de Montreal; McGill University;
   McGill University; McGill University; Laval University; Laval
   University; University of Sherbrooke; Universite de Montreal
RP Belleville, S (corresponding author), Inst Univ Geriatrie Montreal, Ctr Rech, 4545 Chemin Queen Mary, Montreal, PQ H3W 1W5, Canada.
EM sylvie.belleville@umontreal.ca
RI Grenier, Sébastien/AAA-4573-2021
OI Hudon, Carol/0000-0002-7554-3187; Ouellet,
   Marie-Christine/0000-0003-3477-1893; Bier, Nathalie/0000-0002-2940-694X;
   Brodeur, Catherine/0000-0001-9885-9478
FU Canadian Institutes of Health Research (CIHR); Fonds de recherche du
   Quebec - Sante; CIHR
FX The Canadian Institutes of Health Research (CIHR) funded this project.
   Carol Hudon and Marie-Christine Ouellet received a salary award from the
   Fonds de recherche du Quebec - Sante. Sebastien Grenier received a
   postdoctoral fellowship from CIHR. We particularly want to thank Samira
   Mellah who coordinated the pilot study.
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NR 104
TC 12
Z9 14
U1 0
U2 30
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD MAR
PY 2015
VL 27
IS 3
BP 511
EP 525
DI 10.1017/S1041610214001902
PG 15
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA CD4MM
UT WOS:000351057100017
PM 25268968
DA 2023-08-17
ER

PT J
AU Lee, J
AF Lee, Junga
TI Effects of Aerobic and Resistance Exercise Interventions on Cognitive
   and Physiologic Adaptations for Older Adults with Mild Cognitive
   Impairment: A Systematic Review and Meta-Analysis of Randomized Control
   Trials
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE mild cognitive impairment; aerobic exercise; resistance exercise;
   randomized controlled trials; meta-analysis
ID PHYSICAL-EXERCISE; STRENGTH; ASSOCIATION; PERFORMANCE; DISEASE; WALKING;
   WOMEN; CARE
AB (1) Background: The purpose of this meta-analysis is to investigate the effects of exercise intervention for older adults with mild cognitive impairment (MCI). (2) Methods: Databases including PubMed, Medline, and Cochrane were used to search for studies that reported effects of exercise for older adults with MCI and randomized controlled trials up to July 2020. Exercise interventions of all selected studies were summarized, and effect sizes of exercise interventions were calculated. (3) Results: A total of 14 studies, including 1178 older adults with MCI were included. Exercise participation in older adults with MCI improved cognitive functions (d = 0.88, 95% confidence interval [CI]; 0.10-1.65, p = 0.01; k = 5]) and handgrip strength (d = 0.62, 95% CI; 0.23-1.01, p = 0.00; k = 4) compared with control groups. Aerobic exercise or resistance exercise at moderate to vigorous levels for at least 150 min, 1 time/week, for 6 weeks was the minimum level to obtain beneficial effects from exercise for older adults with MCI. (4) Conclusions: Older adults with MCI who participated in exercise received beneficial effects, including improvement in cognitive functions and handgrip strength, but further studies to confirm the effects are needed.
C1 [Lee, Junga] Kyung Hee Univ, Sports Med & Sci, Yongin, Gyeonggi Do, South Korea.
C3 Kyung Hee University
RP Lee, J (corresponding author), Kyung Hee Univ, Sports Med & Sci, Yongin, Gyeonggi Do, South Korea.
EM jalee@khu.ac.kr
RI Lee, Junga/AGL-1462-2022
FU National Research Foundation of Korea [NRF-2020S1A5A8044129]; National
   Research Foundation of Korea [2020S1A5A8044129] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
FX This research was supported by the National Research Foundation of Korea
   (NRF-2020S1A5A8044129).
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NR 38
TC 13
Z9 13
U1 6
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2020
VL 17
IS 24
AR 9216
DI 10.3390/ijerph17249216
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA PK9IC
UT WOS:000602748200001
PM 33317169
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Chow, G
   Gan, JKE
   Chan, JKY
   Wu, XV
   Klainin-Yobas, P
AF Chow, Gigi
   Gan, Javeil Ke En
   Chan, Janice Kuang Yeung
   Wu, Xi Vivien
   Klainin-Yobas, Piyanee
TI Effectiveness of psychosocial interventions among older adults with mild
   cognitive impairment: a systematic review and meta-analysis
SO AGING & MENTAL HEALTH
LA English
DT Review
DE Behavior therapy; cognitive therapy; cognitive function; older adults;
   mild cognitive impairment
ID RANDOMIZED CONTROLLED-TRIAL; DEPRESSIVE SYMPTOMS; ALZHEIMERS-DISEASE;
   REHABILITATION; PEOPLE; INDIVIDUALS; THERAPY; MEMORY; LIFE
AB Objectives
   This review aimed to examine available evidence concerning the effectiveness of psychosocial interventions in improving memory, executive function, depression and activities of daily living (ADL) in older adults with MCI.
   Methods
   Eight electronic databases were used to conduct a comprehensive literature search for published and unpublished studies. A primary outcome was cognitive function, including memory and executive function. Secondary outcomes were depression and ADL. Two researchers independently appraised quality of included studies and extracted data. Meta-analysis, heterogeneity test, subgroup analysis and sensitivity analyses were performed.
   Results
   Ten studies (out of 1,265 records) were included in this review. Psychosocial interventions contributed to a significant improvement in memory, not executive function, depression and ADL. Subgroup analyses suggested that interventions with a longer duration, more therapeutic sessions, and individual format had larger effect sizes. Strategies found to enhance memory entailed behavior modification and activation, memory training, visual imagery, storytelling, memory aids, journaling, and exercise.
   Conclusion
   Healthcare providers may offer psychosocial interventions to client with MCI in clinical settings. Higher quality trials should be conducted to increase solid evidence in this domain.
C1 [Chow, Gigi; Gan, Javeil Ke En] Khoo Teck Puat Hosp, Singapore, Singapore.
   [Chan, Janice Kuang Yeung] Changi Gen Hosp, Singapore, Singapore.
   [Wu, Xi Vivien; Klainin-Yobas, Piyanee] Natl Univ Singapore, Clin Res Ctr, Alice Lee Ctr Nursing Studies, Level 2, Singapore, Singapore.
C3 Changi General Hospital; National University of Singapore
RP Klainin-Yobas, P (corresponding author), Natl Univ Singapore, Clin Res Ctr, Alice Lee Ctr Nursing Studies, Level 2, Singapore, Singapore.
EM nurpk@nus.edu.sg
OI Chow, Gigi/0000-0001-5165-7019
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NR 57
TC 15
Z9 15
U1 2
U2 14
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD NOV 2
PY 2021
VL 25
IS 11
BP 1986
EP 1997
DI 10.1080/13607863.2020.1839861
EA NOV 2020
PG 12
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA WI2PY
UT WOS:000589851200001
PM 33200623
DA 2023-08-17
ER

PT J
AU Passmore, PA
AF Passmore, P. A.
TI A minimum data set for intervention studies on cognitive decline (mild
   cognitive impairment, early Alzheimer) in the elderly
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
ID RATING-SCALE; DEMENTIA; DISEASE; INVENTORY; DEPRESSION; VALIDATION;
   DIAGNOSIS; MEMORY; HEALTH
C1 Queenis Univ Belfast, Dept Geriatr Med, Belfast BT9 7BL, Antrim, North Ireland.
RP Passmore, PA (corresponding author), Queenis Univ Belfast, Dept Geriatr Med, Whitla Med Bldg,97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland.
EM p.passmore@qub.ac.uk
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NR 36
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD MAY-JUN
PY 2007
VL 11
IS 3
BP 278
EP 281
PG 4
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 175ZR
UT WOS:000247053000013
PM 17508108
DA 2023-08-17
ER

PT J
AU Leung, P
   Orrell, M
   Orgeta, V
AF Phuong Leung
   Orrell, Martin
   Orgeta, Vasiliki
TI Social support group interventions in people with dementia and mild
   cognitive impairment: a systematic review of the literature
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE dementia; mild cognitive impairment; social support groups; psychosocial
   interventions; RCTs
ID EARLY-STAGE DEMENTIA; RANDOMIZED CONTROLLED-TRIAL; ALZHEIMERS-DISEASE;
   MEMORY CLUB; CAREGIVERS; PROGRAM; DEPRESSION; BEHAVIOR; OUTCOMES; EVENTS
AB ObjectivesDespite the large number of studies evaluating social support groups for people with dementia, there are no systematic reviews of current evidence. The aim of this study was to evaluate the effectiveness of social support group interventions for people with dementia and mild cognitive impairment.
   MethodsA systematic review was performed. We searched electronic databases for randomised controlled trials. Two reviewers worked independently to select trials, extract data and assess risk of bias.
   ResultsA total of 546 studies were identified of which two met the inclusion criteria. We were not able to pool data for further analyses, as the interventions tested in the studies meeting the inclusion criteria were too dissimilar in content. The first trial (n=136) showed a benefit of early-stage memory loss social support groups for depression and quality of life in people with dementia. The second trial (n=33) showed that post-treatment self-reported self-esteem was higher in the group receiving a multicomponent intervention of social support compared with that in the no intervention control group.
   ConclusionsLimited data from two studies suggest that support groups may be of psychological benefit to people with dementia by reducing depression and improving quality of life and self-esteem. These findings need to be viewed in light of the small number, small sample size and heterogeneous characteristics of current trials, indicating that it is difficult to draw any conclusions. More multicentre randomised controlled trials in social support group interventions for people with dementia are needed. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Phuong Leung; Orrell, Martin; Orgeta, Vasiliki] UCL, Div Psychiat, London, England.
C3 University of London; University College London
RP Orgeta, V (corresponding author), UCL, Div Psychiat, London, England.
EM v.orgeta@ucl.ac.uk
OI Orrell, Martin/0000-0002-1169-3530; Orgeta, Vasiliki/0000-0001-8643-5061
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NR 61
TC 59
Z9 60
U1 2
U2 61
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD JAN
PY 2015
VL 30
IS 1
BP 1
EP 9
DI 10.1002/gps.4166
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA AW4WM
UT WOS:000346278300001
PM 24990344
DA 2023-08-17
ER

PT J
AU Salzman, T
   Sarquis-Adamson, Y
   Son, S
   Montero-Odasso, M
   Fraser, S
AF Salzman, Talia
   Sarquis-Adamson, Yanina
   Son, Surim
   Montero-Odasso, Manuel
   Fraser, Sarah
TI Associations of Multidomain Interventions With Improvements in Cognition
   in Mild Cognitive Impairment A Systematic Review and Meta-analysis
SO JAMA NETWORK OPEN
LA English
DT Review
ID OLDER-ADULTS; DOUBLE-BLIND; MULTICOMPONENT INTERVENTION; EXERCISE
   PROGRAM; IMPACT; RISK; GAIT; DEMENTIA; DISEASE; SENIORS
AB IMPORTANCE Older adults with mild cognitive impairment (MCI) have the highest risk of progressing to dementia. Evidence suggests that nonpharmacological, single-domain interventions can prevent or delay progressive declines, but it is unclear whether greater cognitive benefits arise from multidomain interventions.
   OBJECTIVE To determine whether multidomain interventions, composed of 2 or more interventions, are associated with greater improvements in cognition among older adults with MCI than a single intervention on its own.
   DATA SOURCES MEDLINE, Embase, PsycInfo, Ageline, CINAHL, and Cochrane Central Register of Controlled Trials were systematically searched from database inception to December 20. 2021.
   STUDY SELECTION Included studies contained (1) an MCI diagnosis; (2) nonpharmacological, multidomain interventions that were compared with a single active control; (3) older adults aged 65 years and older; and (4) randomized clinical trials.
   DATA EXTRACTION AND SYNTHESIS Data were screened and extracted by 3 independent reviewers. Following Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, random-effects meta-analyses were used to calculate effect sizes from the standardized mean difference (SMD) and 95% CIs.
   MAIN OUTCOMES AND MEASURES Postintervention cognitive test scores in 7 cognitive domains were compared between single-domain and multidomain groups. Exposure to the intervention was analyzed.
   RESULTS A total of 28 studies published between 2011 and 2021, including 2711 older adults with MCI, reported greater effect sizes in the multidomain group for global cognition (SMD, 0.41; 95% CI, 0.23-0.59; P < .001). executive function (SMD. 0.20; 95% Cl. 0.04-0.36; P = .01), memory (SMD. 0.29; 95% CI, 0.14-0.45; P < .001), and verbal fluency (SMD, 0.30; 95% Cl. 0.12-0.49; P = .001). The Mini-Mental State Examination (SMD, 0.40; 95% CI, 0.17-0.64; P < .001), category verbal fluency test (SMD, 0.34; 95% CI, 0.13-0.56; P = .002), Trail Making Test-B (SMD. 0.46; 95% CI, 0.13-0.80; P = .007), and Wechsler Memory Scale-Logical Memory I (SMD, 0.47; 95% Cl. 0.15-0.80; P < .001) and II (SMD, 0.26; 95% CI, 0.07-0.45; P < .001) favored the multidomain group. Exposure to the intervention varied between studies: the mean (SD) duration was 71.3 (36.0) minutes for 19.8 (14.6) weeks with sessions taking place 2.5 (1.1) times per week, and all interventions lasted less than 1 year.
   CONCLUSIONS AND RELEVANCE In this study, short-term multidomain interventions (<1 year) were associated with improvements in global cognition, executive function, memory, and verbal fluency compared with single interventions in older adults with MCI.
C1 [Salzman, Talia] Univ Ottawa, Fac Hlth Sci, Sch Human Kinet, Ottawa, ON, Canada.
   [Sarquis-Adamson, Yanina; Son, Surim; Montero-Odasso, Manuel] Parkwood Inst, Lawson Hlth Res Inst, Gait & Brain Lab, London, ON, Canada.
   [Son, Surim; Montero-Odasso, Manuel] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada.
   [Montero-Odasso, Manuel] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med & Div Geriatr Med, London, ON, Canada.
   [Fraser, Sarah] Univ Ottawa, Fac Hlth Sci, Interdisciplinary Sch Hlth Sci, London, ON, Canada.
C3 University of Ottawa; Western University (University of Western
   Ontario); Western University (University of Western Ontario); Western
   University (University of Western Ontario); University of Ottawa
RP Fraser, S (corresponding author), Univ Ottawa, Interdisciplinary Sch Hlth Sci, 25 Univ Private, Ottawa, ON K1N 7K4, Canada.
EM Sarah.Fraser@uottawa.ca
FU Canadian Institute of Health Research [MOP 211220, PJT 153100]; Ontario
   Ministry of Research and Innovation [ER11-08-101]; Ontario
   Neurodegenerative Diseases Research Initiative [OBI 34739]; Canadian
   Consortium on Neurodegeneration in Aging [FRN CNA 137794]; Department of
   Medicine Program of Experimental Medicine Research Award [POEM 768915];
   University of Western Ontario; Schulich Clinician-Scientist Award
FX Dr Montero-Odasso's program in Gait and Brain Health is supported by
   grants from the Canadian Institute of Health Research (MOP 211220; PJT
   153100), the Ontario Ministry of Research and Innovation (ER11-08-101),
   the Ontario Neurodegenerative Diseases Research Initiative (OBI 34739),
   the Canadian Consortium on Neurodegeneration in Aging (FRN CNA 137794),
   and Department of Medicine Program of Experimental Medicine Research
   Award (POEM 768915), University ofWestern Ontario. He is also the first
   recipient of the Schulich Clinician-Scientist Award.
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NR 64
TC 10
Z9 10
U1 3
U2 13
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD MAY 3
PY 2022
VL 5
IS 5
AR e226744
DI 10.1001/jamanetworkopen.2022.6744
PG 22
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 1A0WP
UT WOS:000791487600001
PM 35503222
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Hung, L
   Levine, H
   Randhawa, P
   Park, J
AF Hung, Lillian
   Levine, Hannah
   Randhawa, Paavan
   Park, Juyoung
TI Technology-based group exercise interventions for people living with
   dementia or mild cognitive impairment: a scoping review protocol
SO BMJ OPEN
LA English
DT Review
DE dementia; telemedicine; world wide web technology; geriatric medicine
ID OLDER-ADULTS; PSYCHOLOGICAL SYMPTOMS; LONELINESS; MANAGEMENT; STRENGTH;
   BALANCE
AB Introduction More than 50 million people worldwide are living with dementia in 2020, and this number is expected to double every 20 years. Physical exercise is a growing field in non-pharmacological interventions for dementia care. Due to public health measures during the COVID-19 pandemic, more people have considered adapting to technology-based exercise via digital devices. This scoping review will explore evidence relating to the use of technology-based group exercise by people with dementia or mild cognitive impairment. Methods and analysis This review will follow the Joanna Briggs Institute scoping review methodology to review literature published between June and December 2021. This review is designed to identify existing types of technology-based group exercise interventions for people with dementia. The review will provide a synthesis of current evidence on the outcome and impacts of technology-based group exercise. The context of this review will include homes, assisted living facilities and memory care services but exclude hospitals. The review will include a three-step search strategy: (a) identify keywords from MEDLINE and Embase, (b) search using the identified keywords in databases (MEDLINE/PubMed, CINAHL, Web of Science, Embase, Cochrane Library, PsychInfo and Google) and (c) review references from included studies to identify additional studies. Only studies in English will be included. Four researchers will independently assess titles and abstracts and then review the full text of the selected articles, applying the inclusion criteria. The extracted data will be presented in tables and summarised narratively. Ethics and dissemination Scoping review data will be collected from publicly available articles; research ethics approval is not required. The findings will be disseminated to healthcare practitioners and the public through a peer-reviewed publication and conference presentations.
C1 [Hung, Lillian] Univ British Columbia, Sch Nursing, Vancouver, BC, Canada.
   [Hung, Lillian] Vancouver Gen Hosp, Sch Nursing, Vancouver, BC, Canada.
   [Levine, Hannah] Florida Atlantic Univ, Charles E Schmidt Coll Med, Marcus Inst Integrat Hlth, FAU Med, Boca Raton, FL 33431 USA.
   [Randhawa, Paavan] Langara Coll, Fac Gen Sci, Vancouver, BC, Canada.
   [Park, Juyoung] Florida Atlantic Univ, Coll Social Work & Criminal Justice, Phyllis & Harvey Sandler Sch Social Work, Boca Raton, FL 33431 USA.
C3 University of British Columbia; University of British Columbia; State
   University System of Florida; Florida Atlantic University; State
   University System of Florida; Florida Atlantic University
RP Levine, H (corresponding author), Florida Atlantic Univ, Charles E Schmidt Coll Med, Marcus Inst Integrat Hlth, FAU Med, Boca Raton, FL 33431 USA.
EM hlevine2016@health.fau.edu
RI Hung, Lillian/ABC-9937-2020
OI Hung, Lillian/0000-0002-7916-2939; Levine, Hannah/0000-0003-3441-8395;
   Park, Juyoung/0000-0001-6737-3109
FU Marcus Institute of Integrative Health at FAU Medicine [2485]
FX This work was supported by the Marcus Institute of Integrative Health at
   FAU Medicine, grant number 2485.
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NR 32
TC 4
Z9 4
U1 2
U2 7
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAR
PY 2022
VL 12
IS 3
AR e055990
DI 10.1136/bmjopen-2021-055990
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 0C1ZT
UT WOS:000775120600026
PM 35351717
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Baron, S
   Ulstein, I
   Werheid, K
AF Baron, Stefanie
   Ulstein, Ingun
   Werheid, Katja
TI Psychosocial interventions in Alzheimer's disease and amnestic mild
   cognitive impairment: evidence for gender bias in clinical trials
SO AGING & MENTAL HEALTH
LA English
DT Article
DE Alzheimer`s disease; dementia; psychosocial interventions; gender
   differences; mild cognitive impairment
ID NURSING-HOME RESIDENTS; RANDOMIZED CONTROLLED-TRIAL; EMOTION-ORIENTED
   CARE; SEX-DIFFERENCES; EXERCISE PROGRAM; OLDER-ADULTS; NEUROPSYCHIATRIC
   SYMPTOMS; BEHAVIORAL-MANAGEMENT; VASCULAR DEMENTIA; MUSIC-THERAPY
AB Background: Alzheimer's disease (AD) affects twice as many women as men. Gender differences in symptom profile, living conditions, coping style and response might affect the outcome of psychosocial interventions (PSIs).
   Objectives: Our aim was to review gender differences in the available high-quality phase III trials on PSI in AD and amnestic mild cognitive impairment (aMCI) by considering the gender ratio in the investigated samples.
   Design: Randomized controlled trials published in 2000-2012 were stepwise analyzed by statistically testing the representativeness of the gender ratio and examining reported gender differences.
   Results: Forty-five studies (62% of 73 studies) reported gender ratios for each subsample and were included. In these studies, females were underrepresented in the control groups. In the 14 studies (19%) reporting analyses of gender differences, women were underrepresented in both intervention and control groups. However, in the six studies (8%) reporting significant gender differences in outcome, gender distribution was in accordance with prevalence rates.
   Conclusion: Current evidence is insufficient for reliable conclusions on gender differences in PSI outcome in AD and aMCI, as 81% of the available clinical trials either not reported the gender ratio of their samples, or underrepresent females. Further research is needed addressing gender differences, and clinical trials should routinely control for gender bias.
C1 [Baron, Stefanie; Werheid, Katja] Humboldt Univ, Dept Psychol, D-10099 Berlin, Germany.
   [Ulstein, Ingun] Oslo Univ Hosp, Dept Old Age Psychiat, Oslo, Norway.
C3 Humboldt University of Berlin; University of Oslo
RP Werheid, K (corresponding author), Humboldt Univ, Dept Psychol, D-10099 Berlin, Germany.
EM katja.werheid@cms.hu-berlin.de
FU Humboldt University
FX The study was supported by the Humboldt University Fund for Gender
   Equality 2011.
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NR 105
TC 15
Z9 15
U1 0
U2 40
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD APR 3
PY 2015
VL 19
IS 4
BP 290
EP 305
DI 10.1080/13607863.2014.938601
PG 16
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA AZ6EP
UT WOS:000348311900001
PM 25048626
DA 2023-08-17
ER

PT J
AU Locke, DE
   Cuc, AV
   Snyder, CH
   Fields, JA
   Smith, GE
   Chandler, M
AF Locke, D. E.
   Cuc, A. V.
   Snyder, C. H.
   Fields, J. A.
   Smith, G. E.
   Chandler, M.
TI Preliminary patient and partner outcomes in a randomized trial of two
   cognitive rehabilitation interventions for Mild Cognitive Impairment
SO CLINICAL NEUROPSYCHOLOGIST
LA English
DT Meeting Abstract
NR 0
TC 0
Z9 0
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1385-4046
EI 1744-4144
J9 CLIN NEUROPSYCHOL
JI Clin. Neuropsychol.
PY 2016
VL 30
IS 3
MA 30
BP 387
EP 387
PG 1
WC Psychology, Clinical; Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA DL2NJ
UT WOS:000375471800031
DA 2023-08-17
ER

PT J
AU Davis, KK
   Mintzer, M
   Himmelfarb, CRD
   Hayat, MJ
   Rotman, S
   Allen, J
AF Davis, Karen K.
   Mintzer, Miriam
   Himmelfarb, Cheryl R. Dennison
   Hayat, Matthew J.
   Rotman, Stacey
   Allen, Jerilyn
TI Targeted intervention improves knowledge but not self-care or
   readmissions in heart failure patients with mild cognitive impairment
SO EUROPEAN JOURNAL OF HEART FAILURE
LA English
DT Article
DE Heart failure; Cognitive impairment; Self-care; Cognitive training
ID GUIDELINES; DIAGNOSIS; EDUCATION; OUTCOMES; DISEASE
AB Mild cognitive impairment (MCI) is prevalent in heart failure, and can contribute to poor self-care and higher hospital readmissions. Strategies to improve self-care in patients with MCI have not been studied. This randomized controlled trial aimed to test the effect of a targeted intervention on self-care, heart failure knowledge, and 30-day readmissions.
   The study included 125 patients hospitalized for exacerbation of heart failure who screened positive for MCI. The treatment group received a targeted self-care teaching intervention using principles of cognitive training. Self-care, heart failure knowledge, depression, and social support were assessed at baseline and 30 days post-discharge. Mean heart failure knowledge scores improved significantly in the intervention group, but decreased in the control group (P 0.001). When controlling for other variables, patients in the intervention group showed a greater increase in heart failure knowledge than patients in the control group (P 0.027). Black race was significantly associated with lower heart failure knowledge scores (P 0.030). Mean change scores for self-care showed greater improvement in the intervention group when compared with the control group; however, this was not statistically significant. There was no difference in readmission rates between the groups.
   It is feasible to conduct a randomized controlled trial in patients with MCI. Patients in the treatment group had greater heart failure knowledge at 30 days post-discharge; however, this did not impact readmission rates. Further research is needed to describe how MCI affects self-care and knowledge, and how race and other factors may influence outcomes in this population.
C1 [Davis, Karen K.; Rotman, Stacey] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.
   [Mintzer, Miriam; Allen, Jerilyn] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Davis, Karen K.; Himmelfarb, Cheryl R. Dennison; Allen, Jerilyn] Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA.
   [Hayat, Matthew J.] Rutgers State Univ, Coll Nursing, Newark, NJ 07102 USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins
   University; Johns Hopkins University; Rutgers State University Newark;
   Rutgers State University New Brunswick
RP Davis, KK (corresponding author), Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA.
EM Kdavis4@jhmi.edu
RI Himmelfarb, Cheryl Dennison/V-5660-2019
OI Himmelfarb, Cheryl Dennison/0000-0003-1918-4316
FU Health Service Cost Review Commission
FX The Nursing Support Program I (a grant sponsored by the Health Service
   Cost Review Commission).
CR Albert MS, 2011, ALZHEIMERS DEMENT, V7, P270, DOI 10.1016/j.jalz.2011.03.008
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NR 38
TC 73
Z9 74
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1388-9842
EI 1879-0844
J9 EUR J HEART FAIL
JI Eur. J. Heart Fail.
PD SEP
PY 2012
VL 14
IS 9
BP 1041
EP 1049
DI 10.1093/eurjhf/hfs096
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 995LR
UT WOS:000308010100011
PM 22736737
OA Bronze
DA 2023-08-17
ER

PT J
AU Bayly, M
   Morgan, D
   Kosteniuk, J
   Elliot, V
   Chow, AF
   Peacock, S
   McLean, A
   O'Connell, ME
AF Bayly, Melanie
   Morgan, Debra
   Kosteniuk, Julie
   Elliot, Valerie
   Chow, Amanda Froehlich
   Peacock, Shelley
   McLean, Allen
   O'Connell, Megan E.
TI Protocol for a systematic review on interventions for caregivers of
   persons with mild cognitive impairment and early dementia: does early
   stage intervention improve caregiver well-being and ability to provide
   care?
SO BMJ OPEN
LA English
DT Article
ID PEOPLE; BURDEN; IMPACT; DIAGNOSIS; ANXIETY; SCALE
AB Introduction Caregivers of persons with dementia and mild cognitive impairment (MCI) are at risk of decreased well-being. While many interventions for caregivers exist, evidence is sparse regarding intervention timing and effectiveness at an early stage of cognitive decline. Our systematic review aims to answer the following questions: (1) Do interventions for caregivers of persons with early stage dementia or MCI affect their well-being and ability to provide care? (2) Are particular types of caregiver interventions most effective during early stage cognitive decline? (3) How does effectiveness differ when early and later interventions are directly compared? (4) Do effects of early stage caregiver intervention vary based on care recipient and caregiver characteristics (eg, sex, type of dementia)?
   Methods and analysis The databases MEDLINE, EMBASE, PSYCINFO and CINAHL, as well as grey literature databases, will be searched for English language studies using search terms related to caregiver interventions and dementia/MCI. Abstracts and full texts will be screened by two independent reviewers; included studies must assess the effects of an intervention for caregivers of persons with early stage dementia or MCI on caregiver well-being or ability to provide care. Intervention, study and participant characteristics will be extracted by two independent reviewers, along with outcome data. Risk of bias will be assessed using the Cochrane risk of bias tool (for controlled trials with and without randomisation). Interventions will be grouped by type (eg, psychoeducational) and a narrative synthesis is planned due to expected heterogeneity, but a meta-analysis will be performed where possible. The Grading of Recommendations, Assessment, Development and Evaluations approach will be used to inform conclusions regarding the quality of evidence for each type of intervention.
   Ethics and dissemination Findings from this review will be disseminated via conferences and peer-reviewed publication, and a summary will be provided to the Alzheimer Society.
C1 [Bayly, Melanie; Kosteniuk, Julie; Elliot, Valerie; Chow, Amanda Froehlich] Univ Saskatchewan, Canadian Ctr Hlth & Safety Agr, Saskatoon, SK, Canada.
   [Morgan, Debra] Univ Saskatchewan, Ctr Hlth & Safety Agr, Saskatoon, SK, Canada.
   [Peacock, Shelley] Univ Saskatchewan, Nursing, Saskatoon, SK, Canada.
   [McLean, Allen] Univ Saskatchewan, Coll Med, Saskatoon, SK, Canada.
   [O'Connell, Megan E.] Univ Saskatchewan, Psychol, Saskatoon, SK, Canada.
C3 University of Saskatchewan; University of Saskatchewan; University of
   Saskatchewan; University of Saskatchewan; University of Saskatchewan
RP Bayly, M (corresponding author), Univ Saskatchewan, Canadian Ctr Hlth & Safety Agr, Saskatoon, SK, Canada.
EM mke177@mail.usask.ca
OI Bayly, Melanie/0000-0001-5285-839X; O'Connell, Megan
   E/0000-0001-6159-4322
FU Saskatchewan Health Research Foundation through Canadian Institutes of
   Health Research; Canadian Consortium on Neurodegeneration in Aging
   (CCNA) [3431]
FX This work was supported by the Saskatchewan Health Research Foundation
   through a partnership with the Canadian Institutes of Health Research,
   in support of the Canadian Consortium on Neurodegeneration in Aging
   (CCNA) (grant number 3431).
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NR 46
TC 3
Z9 3
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2019
VL 9
IS 5
AR e028441
DI 10.1136/bmjopen-2018-028441
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA IC7YG
UT WOS:000471192800353
PM 31079088
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Banningh, LWAJW
   Vernooij-Dassen, MJFJ
   Vullings, M
   Prins, JB
   Rikkert, MGMO
   Kessels, RPC
AF Banningh, Liesbeth W. A. Joosten-Weyn
   Vernooij-Dassen, Myrra J. F. J.
   Vullings, Marjon
   Prins, Judith B.
   Rikkert, Marcel G. M. Olde
   Kessels, Roy P. C.
TI Learning to Live With a Loved One With Mild Cognitive Impairment:
   Effectiveness of a Waiting List Controlled Trial of a Group Intervention
   on Significant Others' Sense of Competence and Well-being
SO AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
LA English
DT Article
DE mild cognitive impairment; caregivers; psychotherapy; psychoeducation;
   group therapy; qualitative study
ID GROUP-THERAPY; DEMENTIA; BURDEN; MEMORY; CARE; QUESTIONNAIRE;
   CAREGIVERS; ILLNESS; PEOPLE; ADULTS
AB This controlled study examines the efficacy of a comprehensive group program aimed at care partners of patients with mild cognitive impairment (MCI), which comprises elements of psychoeducation, cognitive rehabilitation, and cognitive behavioral therapy. Pre- and posttreatment quantitative and qualitative data were collected in the significant others of 84 patients with MCI, 27 of whom had first been assigned to a waiting list, thus serving as their own control group. Also, the significant others rated their sense of competence, well-being, distress, acceptance, helplessness, and awareness. Quantitative data analysis did not reveal statistically significant differences between the control and the intervention condition, but qualitative results suggest that at program completion the significant others reported gains in knowledge, insight, acceptance, and coping skills. In the present sample of significant others, the group intervention was not proven effective. Suggestions for program adjustments and alternative outcome measures are discussed.
C1 [Banningh, Liesbeth W. A. Joosten-Weyn; Vullings, Marjon; Prins, Judith B.; Kessels, Roy P. C.] Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, NL-6500 HB Nijmegen, Netherlands.
   [Banningh, Liesbeth W. A. Joosten-Weyn; Vernooij-Dassen, Myrra J. F. J.; Rikkert, Marcel G. M. Olde; Kessels, Roy P. C.] Radboud Univ Nijmegen, Med Ctr, Dept Geriatr, NL-6500 HB Nijmegen, Netherlands.
   [Banningh, Liesbeth W. A. Joosten-Weyn; Vernooij-Dassen, Myrra J. F. J.; Rikkert, Marcel G. M. Olde; Kessels, Roy P. C.] Radboud Univ Nijmegen, Med Ctr, Radboud Alzheimer Ctr, NL-6500 HB Nijmegen, Netherlands.
   [Vernooij-Dassen, Myrra J. F. J.] Radboud Univ Nijmegen, Sci Inst Qual Healthcare, NL-6500 HB Nijmegen, Netherlands.
   [Vernooij-Dassen, Myrra J. F. J.] Kalorama Fdn, Beek Ubbergen, Netherlands.
   [Vernooij-Dassen, Myrra J. F. J.] Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, NL-6500 HB Nijmegen, Netherlands.
   [Vullings, Marjon] VieCurie Hosp, Dept Med Psychol, Venlo, Netherlands.
   [Kessels, Roy P. C.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Radboud
   University Nijmegen; Radboud University Nijmegen; Radboud University
   Nijmegen; VieCuri Medical Center; Radboud University Nijmegen
RP Kessels, RPC (corresponding author), Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM r.kessels@mps.umcn.nl
RI Rikkert, M.G.M. Olde/H-8078-2014; Kessels, Roy P.C./D-1902-2010; Prins,
   Judith B/C-8522-2013; Vernooij-Dassen, M.J.F.J./H-8107-2014
OI Rikkert, M.G.M. Olde/0000-0003-1397-1677; Kessels, Roy
   P.C./0000-0001-9500-9793; 
FU Alzheimer Nederland; Innovatiefonds Zorgverzekeraars (RVVZ); Stichting
   RCOAK [NCT00285753]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: this study was
   supported in part by grants from Alzheimer Nederland, Innovatiefonds
   Zorgverzekeraars (RVVZ), and Stichting RCOAK. Trial registration number:
   NCT00285753 (Clinical Trials.gov).
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NR 41
TC 21
Z9 21
U1 1
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1533-3175
EI 1938-2731
J9 AM J ALZHEIMERS DIS
JI Am. J. Alzheimers Dis. Other Dement.
PD MAY
PY 2013
VL 28
IS 3
BP 228
EP 238
DI 10.1177/1533317513481093
PG 11
WC Geriatrics & Gerontology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 138RG
UT WOS:000318525500004
PM 23528880
DA 2023-08-17
ER

PT J
AU Sun, X
   Wang, LA
   Shen, XH
   Huang, C
   Wei, ZQ
   Su, LM
   Wang, SM
   Liu, XS
   Zhen, XT
AF Sun, Xue
   Wang, Lina
   Shen, Xinhua
   Huang, Cheng
   Wei, Zhuqin
   Su, Liming
   Wang, Simeng
   Liu, Xiaoshen
   Zhen, Xueting
TI Correlates of Adherence of Multimodal Non-pharmacological Interventions
   in Older Adults With Mild Cognitive Impairment: A Cross-Sectional Study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE mild cognitive impairment; adherence; multimodal interventions;
   non-pharmacological interventions; cognitive function
ID HEALTH BELIEF MODEL; ALZHEIMERS-DISEASE; EXERCISE PROGRAMS;
   PHYSICAL-ACTIVITY; PEOPLE; AMERICAN
AB Background: Non-pharmacological interventions are promising for delaying cognitive decline in older adults with mild cognitive impairment (MCI). Although some studies have demonstrated adherence rates and factors influencing participation in single modality non-pharmacological interventions, little is known about the level and correlates of adherence to multimodal non-pharmacological interventions (MNPIs) in older adults with MCI. Objective: This study aimed to explore the adherence level and the correlates of adherence to MNPIs in older adults with MCI. Methods: A cross-sectional design was employed. Community-dwelling older adults aged 60 years and over were recruited from senior community centers and healthcare centers in Huzhou from March 2019 to December 2020. Data were collected by a general information questionnaire and the adherence scale of cognitive dysfunction management (AS-CDM) in older adults with MCI. Hierarchical regression analyses were applied to explore the correlates of adherence to MNPIs. Results: A total of 216 completed questionnaires were finally analyzed. Of these, 68.52% were female, and 45.4% of the participants had no less than 6 years of education. The overall mean score for adherence was 117.58 (SD = 10.51) out of 160, equivalent to 73.49 in the hundred-mark system, indicating a medium-level adherence to MNPIs in older adults with MCI. Of the five dimensions of adherence (AS-CDM), self-efficacy scored the highest, and the lowest was perceived barriers. The univariate analysis showed that the factors associated with the adherence to MNPIs were: regular physical exercise, meat-vegetable balance, absence of multimorbidity, high level of education, living alone, and living in urban (p < 0.05). In the hierarchical regression analysis, the final model explained 18.8% of variance in overall adherence (p < 0.01), which high school (Beta = 0.161, p < 0.05), college and above more (Beta = 0.171, p < 0.05), meat-vegetarian balance (Beta = 0.228, p < 0.05), regular physical exercise (Beta = 0.234, p < 0.05), and presence of multimorbidity (Beta = -0.128, p < 0.05) significantly contributed to adherence. In addition, nearly 80% of older adults with MCI preferred MNPIs. Conclusion: Early assessment and management of adherence to MNPIs were essential in older adults with MCI. Furthermore, the findings shed light on several critical areas of intervention to improve adherence to MNPIs in older adults with MCI.
C1 [Sun, Xue; Wang, Lina; Huang, Cheng; Wei, Zhuqin; Su, Liming; Wang, Simeng] Huzhou Univ, Sch Med, Huzhou, Peoples R China.
   [Shen, Xinhua] Third Peoples Hosp Huzhou, Dept Neurosis & Psychosomat Dis, Huzhou, Peoples R China.
   [Liu, Xiaoshen] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Orthoped, Sch Med, Hangzhou, Peoples R China.
   [Zhen, Xueting] Tongxiang City Hlth Sch, Sch Med, Jiaxing, Peoples R China.
C3 Huzhou University; Zhejiang University
RP Wang, LA (corresponding author), Huzhou Univ, Sch Med, Huzhou, Peoples R China.
EM aring2000@163.com
RI OMOSIGHO, BLESSING/ISS-7818-2023; wang, lin/HZK-4145-2023; wang,
   lina/HGC-1592-2022
FU National Natural Science Foundation of China [72174061, 71704053]; China
   Scholarship Council Foundation [201908330251]; Zhejiang Provincial
   College Students Scientific and Technological Innovation
   Activities-Zhejiang Xinmiao Talents Program [2021R431031]
FX Funding This study was supported by the National Natural Science
   Foundation of China (Nos. 72174061 and 71704053), the China Scholarship
   Council Foundation (No. 201908330251), and the Zhejiang Provincial
   College Students Scientific and Technological Innovation
   Activities-Zhejiang Xinmiao Talents Program (No. 2021R431031).
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NR 53
TC 0
Z9 0
U1 6
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 3
PY 2022
VL 13
AR 833767
DI 10.3389/fpsyt.2022.833767
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 2G9AV
UT WOS:000813893500001
PM 35747098
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Won, J
   Nielson, KA
   Smith, JC
AF Won, Junyeon
   Nielson, Kristy A.
   Smith, J. Carson
TI Subjective Well-Being and Bilateral Anterior Insula Functional
   Connectivity After Exercise Intervention in Older Adults With Mild
   Cognitive Impairment
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE MCI (mild cognitive impairment); exercise; subjective well-being;
   functional connectivity (FC); anterior insula (AI)
ID SEMANTIC MEMORY ACTIVATION; PHYSICAL-ACTIVITY; ALZHEIMERS-DISEASE; LIFE
   SATISFACTION; ASSOCIATION; NETWORKS; DEMENTIA; AGE; METAANALYSIS;
   DEPRESSION
AB While it is well known that exercise training is associated with improvement in subjective well-being among older adults, it is unclear if individuals with cognitive impairment experience the same effects elicited by exercise on subjective well-being. We further explored whether the bilateral anterior insula network may be an underlying neural mechanism for the exercise training-related improvements in subjective well-being. We investigated the effects of exercise training on subjective well-being in older adults (78.4 +/- 7.1 years) with mild cognitive impairment (MCI; n = 14) and a cognitively normal (CN; n = 14) control group. We specifically assessed the relationship between changes in subjective well-being and changes in functional connectivity (FC) with the bilateral anterior insula from before to after exercise training. Cardiorespiratory fitness, subjective well-being, and resting-state fMRI were measured before and after a 12-week moderate-intensity walking intervention. A seed-based correlation analysis was conducted using the bilateral anterior insula as a priori seed regions of interest. The associations between bilateral anterior insula FC with other brain regions and subjective well-being were computed before and after exercise training, respectively, and the statistical difference between the correlations (before vs after exercise training) was evaluated. There was a significant Group (MCI vs CN) x Time (before vs after exercise training) interaction for subjective well-being, such that while those with MCI demonstrated significantly increased subjective well-being after exercise training, no changes in subjective well-being were observed in CN. Participants with MCI also showed an exercise training-related increase in the bilateral anterior insula FC. While there was no significant correlation between subjective well-being and bilateral anterior insula FC before exercise training, a positive association between subjective well-being and bilateral anterior insula FC was found in the MCI group after exercise training. Our findings indicate that 12 weeks of exercise training may enhance subjective well-being in older adults diagnosed with MCI and, further, suggest that increased bilateral anterior insula FC with other cortical regions may reflect neural network plasticity associated with exercise training-related improvements in subjective well-being.
C1 [Won, Junyeon; Smith, J. Carson] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA.
   [Nielson, Kristy A.] Marquette Univ, Dept Psychol, Milwaukee, WI 53233 USA.
   [Nielson, Kristy A.] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 USA.
   [Smith, J. Carson] Univ Maryland, Program Neurosci & Cognit Sci, College Pk, MD 20742 USA.
C3 University System of Maryland; University of Maryland College Park;
   Marquette University; Medical College of Wisconsin; University System of
   Maryland; University of Maryland College Park
RP Smith, JC (corresponding author), Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA.; Smith, JC (corresponding author), Univ Maryland, Program Neurosci & Cognit Sci, College Pk, MD 20742 USA.
EM carson@umd.edu
OI Won, Junyeon/0000-0001-7900-9355
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NR 91
TC 1
Z9 1
U1 4
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAY 10
PY 2022
VL 16
AR 834816
DI 10.3389/fnins.2022.834816
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 1L3PW
UT WOS:000799204800001
PM 35620672
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Lai, X
   Wen, H
   Li, Y
   Lu, LM
   Tang, CZ
AF Lai, Xin
   Wen, Hao
   Li, Yu
   Lu, Liming
   Tang, Chunzhi
TI The Comparative Efficacy of Multiple Interventions for Mild Cognitive
   Impairment in Alzheimer's Disease: A Bayesian Network Meta-Analysis
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE acupuncture; Alzheimer's disease; mild cognitive impairment; multiple
   interventions; music therapy; network meta-analysis
ID MUSIC-THERAPY; VITAMIN-E; DEMENTIA; DONEPEZIL; DECLINE; SUPPLEMENTATION;
   ACUPUNCTURE; SAFETY
AB Background:Mild cognitive impairment (MCI) is the early phase of Alzheimer's disease (AD). The aim of early intervention for MCI is to decrease the rate of conversion from MCI to AD. However, the efficacy of multiple interventions in MCI, and the optimal methods of delivery, remain controversial. We aimed to compare and rank the treatment methods for MCI in AD, in order to find an optimal intervention for MCI and a way to prevent or delay the occurrence of AD. Methods:Pair-wise and network meta-analysis were conducted to integrate the treatment effectiveness through direct and indirect evidence. Four English databases and three Chinese databases were searched for international registers of eligible published, single or double blind, randomized controlled trials up to September 31st 2019. We included nine comparative interventions: pharmacological therapies which incorporated cholinesterase inhibitors (ChEI), ginkgo, nimodipine, and Chinese medicine; non-pharmacological therapies comprising of acupuncture, music therapy, exercise therapy, and nutrition therapy; and a placebo group. The primary outcome was the Mini-Mental State Examination (MMSE) score. The secondary outcome was the AD Assessment Scale-cognitive subscale (ADAS-cog). Results:Twenty-eight trials were eligible, including 6,863 participants. In the direct meta-analysis, as for the Mini-Mental State Examination scale, the ChEIs (MD: -0.38; 95% CI: -0.74, -0.01), Chinese medicine (MD: -0.31; 95% CI: -0.75, 0.13), exercise therapy (MD: -0.50; 95% CI: -0.65, -0.35), music therapy (MD: -1.71; 95% CI: -4.49, 1.07), were statistically more efficient than placebo. For AD Assessment Scalecognitive subscale outcome, ChEIs (MD: 1.20; 95% CI: 0.73, 1.68), Acupuncture (MD: 1.36; 95% CI: 1.28, 1.44), Chinese medicine (MD: 0.61; 95% CI: 0.49, 0.73) and exercise (MD: 0.61; 95% CI: 0.49, 0.73) were better than placebo. In the network meta-analysis, the MMSE outcome ranked music therapy (59%) as the best and Acupuncture (26%) as second. Nutrition and Ginkgo treatment had the lowest rank among all interventions. For ADAS-cog outcome, acupuncture (52) ranked the best. Conclusion:Among the nine treatments studied, music therapy appears to be the best treatment for MCI, followed by acupuncture. Our study provides new insights into potential clinical treatments for MCI due to AD, and may aid the development of guidelines for MCI in AD.
C1 [Lai, Xin; Wen, Hao; Li, Yu; Lu, Liming; Tang, Chunzhi] Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine
RP Tang, CZ (corresponding author), Guangzhou Univ Chinese Med, Med Coll Acu Moxi & Rehabil, Guangzhou, Peoples R China.
EM jordan664@163.com
FU National Natural Science Foundation of China [81873375]
FX This work was funded by grants from National Natural Science Foundation
   of China (No. 81873375).
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NR 57
TC 18
Z9 18
U1 3
U2 39
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JUN 5
PY 2020
VL 12
AR 121
DI 10.3389/fnagi.2020.00121
PG 12
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA MC0GJ
UT WOS:000542975700001
PM 32581760
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Bohnen, JLB
   Albin, RL
   Bohnen, NI
AF Bohnen, Jeffrey L. B.
   Albin, Roger L.
   Bohnen, Nicolaas I.
TI Ketogenic interventions in mild cognitive impairment, Alzheimer's
   disease, and Parkinson's disease: A systematic review and critical
   appraisal
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE Alzheimer's disease; mild cognitive impairment; Parkinson's disease;
   ketogenic; effectiveness
ID ENERGY-METABOLISM; BETA-HYDROXYBUTYRATE; HYPERKETONEMIA; ROLES
AB Background. There is increasing interest in therapeutic ketosis as a potential therapy for neurodegenerative disorders-in particular, mild cognitive impairment (MCI), Alzheimer's disease (AD), and Parkinson's disease (PD)-following a proof-of-concept study in Parkinson's disease published in 2005.Methods. To provide an objective assessment of emerging clinical evidence and targeted recommendations for future research, we reviewed clinical trials involving ketogenic interventions in mild cognitive impairment, Alzheimer's disease, and Parkinson's disease reported since 2005. Levels of clinical evidence were systematically reviewed using the American Academy of Neurology criteria for rating therapeutic trials.Results. 10 AD, 3 MCI, and 5 PD therapeutic ketogenic trials were identified. Respective grades of clinical evidence were objectively assessed using the American Academy of Neurology criteria for rating therapeutic trials. We found class "B " evidence (probably effective) for cognitive improvement in subjects with mild cognitive impairment and subjects with mild-to-moderate Alzheimer's disease negative for the apolipoprotein epsilon 4 allele (APO epsilon 4-). We found class "U " evidence (unproven) for cognitive stabilization in individuals with mild-to-moderate Alzheimer's disease positive for the apolipoprotein epsilon 4 allele (APO epsilon 4+). We found class "C " evidence (possibly effective) for improvement of non-motor features and class "U " evidence (unproven) for motor features in individuals with Parkinson's disease. The number of trials in Parkinson's disease is very small with best evidence that acute supplementation holds promise for improving exercise endurance.Conclusions. Limitations of the literature to date include the range of ketogenic interventions currently assessed in the literature (i.e., primarily diet or medium-chain triglyceride interventions), with fewer studies using more potent formulations (e.g., exogenous ketone esters). Collectively, the strongest evidence to date exists for cognitive improvement in individuals with mild cognitive impairment and in individuals with mild-to-moderate Alzheimer's disease negative for the apolipoprotein epsilon 4 allele. Larger-scale, pivotal trials are justified in these populations. Further research is required to optimize the utilization of ketogenic interventions in differing clinical contexts and to better characterize the response to therapeutic ketosis in patients who are positive for the apolipoprotein epsilon 4 allele, as modified interventions may be necessary.
C1 [Bohnen, Jeffrey L. B.; Albin, Roger L.; Bohnen, Nicolaas I.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Albin, Roger L.; Bohnen, Nicolaas I.] VA Ann Arbor Healthcare Syst, Neurol Serv, GRECC, Ann Arbor, MI 48105 USA.
   [Albin, Roger L.; Bohnen, Nicolaas I.] Univ Michigan, Morris K Udall Ctr Excellence Parkinsons Dis Res, Ann Arbor, MI 48109 USA.
   [Albin, Roger L.; Bohnen, Nicolaas I.] Univ Michigan, Parkinsons Fdn Res Ctr Excellence, Ann Arbor, MI 48109 USA.
   [Bohnen, Nicolaas I.] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; Geriatric
   Research Education & Clinical Center; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Ann Arbor Healthcare System;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan
RP Bohnen, NI (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.; Bohnen, NI (corresponding author), VA Ann Arbor Healthcare Syst, Neurol Serv, GRECC, Ann Arbor, MI 48105 USA.; Bohnen, NI (corresponding author), Univ Michigan, Morris K Udall Ctr Excellence Parkinsons Dis Res, Ann Arbor, MI 48109 USA.; Bohnen, NI (corresponding author), Univ Michigan, Parkinsons Fdn Res Ctr Excellence, Ann Arbor, MI 48109 USA.; Bohnen, NI (corresponding author), Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA.
EM nbohnen@umich.edu
FU Farmer Family Foundation
FX This work was funded by the Farmer Family Foundation.
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NR 62
TC 2
Z9 2
U1 8
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD FEB 9
PY 2023
VL 14
AR 1123290
DI 10.3389/fneur.2023.1123290
PG 18
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 9E9OA
UT WOS:000937106300001
PM 36846143
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Baumel, BS
   Doraiswamy, PM
   Sabbagh, M
   Wurtman, R
AF Baumel, Barry S.
   Doraiswamy, P. Murali
   Sabbagh, Marwan
   Wurtman, Richard
TI Potential Neuroregenerative and Neuroprotective Effects of
   Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild
   Cognitive Impairment: A Narrative Review
SO NEUROLOGY AND THERAPY
LA English
DT Review
DE Alzheimer disease; Choline; Docosahexaenoic acid; Mild cognitive
   impairment; Multinutrient; Uridine
ID MEMBRANE PHOSPHOLIPID ALTERATIONS; ETHANOLAMINE PLASMALOGEN DEFICIENCY;
   ALZHEIMERS ASSOCIATION WORKGROUPS; MULTI-NUTRIENT DIET;
   CEREBROSPINAL-FLUID; DOUBLE-BLIND; DOCOSAHEXAENOIC ACID; OLDER-ADULTS;
   FATTY-ACIDS; DIAGNOSTIC GUIDELINES
AB In mild cognitive impairment (MCI) due to Alzheimer disease (AD), also known as prodromal AD, there is evidence for a pathologic shortage of uridine, choline, and docosahexaenoic acid [DHA]), which are key nutrients needed by the brain. Preclinical and clinical evidence shows the importance of nutrient bioavailability to support the development and maintenance of brain structure and function in MCI and AD. Availability of key nutrients is limited in MCI, creating a distinct nutritional need for uridine, choline, and DHA. Evidence suggests that metabolic derangements associated with ageing and disease-related pathology can affect the body's ability to generate and utilize nutrients. This is reflected in lower levels of nutrients measured in the plasma and brains of individuals with MCI and AD dementia, and progressive loss of cognitive performance. The uridine shortage cannot be corrected by normal diet, making uridine a conditionally essential nutrient in affected individuals. It is also challenging to correct the choline shortfall through diet alone, because brain uptake from the plasma significantly decreases with ageing. There is no strong evidence to support the use of single-agent supplements in the management of MCI due to AD. As uridine and choline work synergistically with DHA to increase phosphatidylcholine formation, there is a compelling rationale to combine these nutrients. A multinutrient enriched with uridine, choline, and DHA developed to support brain function has been evaluated in randomized controlled trials covering a spectrum of dementia from MCI to moderate AD. A randomized controlled trial in subjects with prodromal AD showed that multinutrient intervention slowed brain atrophy and improved some measures of cognition. Based on the available clinical evidence, nutritional intervention should be considered as a part of the approach to the management of individuals with MCI due to AD, including adherence to a healthy, balanced diet, and consideration of evidence-based multinutrient supplements.
C1 [Baumel, Barry S.] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.
   [Doraiswamy, P. Murali] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Durham, NC USA.
   [Sabbagh, Marwan] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA.
   [Wurtman, Richard] MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA.
C3 University of Miami; Duke University; Cleveland Clinic Foundation;
   Massachusetts Institute of Technology (MIT)
RP Baumel, BS (corresponding author), Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.
EM b.baumel@miami.edu
OI Baumel, bernard/0000-0003-2903-3861
FU Nutricia
FX This manuscript is based on the proceedings of a round table funded by
   Nutricia and attended by the authors. Nutricia funded the rapid service
   fee for publication.
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NR 149
TC 9
Z9 9
U1 4
U2 19
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 2193-8253
EI 2193-6536
J9 NEUROL THER
JI Neurol. Ther.
PD JUN
PY 2021
VL 10
IS 1
BP 43
EP 60
DI 10.1007/s40120-020-00227-y
EA DEC 2020
PG 18
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SF9AL
UT WOS:000602292300001
PM 33368017
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Johari, SM
   Shahar, S
   Ng, TP
   Rajikan, R
AF Johari, Sa'ida Munira
   Shahar, Suzana
   Ng, Tze Pin
   Rajikan, Roslee
TI A Preliminary Randomized Controlled Trial of Multifaceted Educational
   Intervention for Mild Cognitive Impairment Among Elderly Malays in Kuala
   Lumpur
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Article
DE elderly; lifestyle; mild cognitive impairment; nutrition
ID QUALITY-OF-LIFE; OLDER-ADULTS; NUTRITION EDUCATION; ALZHEIMER-DISEASE;
   PHYSICAL-ACTIVITY; DOUBLE-BLIND; RISK-FACTORS; FATTY-ACIDS; PERFORMANCE;
   VITAMIN
AB Background: The aim of this study was to determine the effect of health education in changing nutritional, lifestyle, and cognitive function of elderly individuals with mild cognitive impairment (MCI).
   Methods: Thirty-five elderly individuals with MCI (mean age 65.7 +/- 3.8 years, 45.7% men) were randomly assigned to intervention (n = 17) and control (n = 18) groups. The intervention group participated in monthly sessions on nutrition and lifestyle education for 12 months, based on a booklet ('7 Guides to Enhance Elderly Memory'). Outcomes (cognitive performance, biomarkers, dietary intake, and knowledge, attitude and practice, knowledge, attitude, and practice score) were measured at 6 and 12 months.
   Results: Repeated-measure analysis of covariance showed significant improvements in serum B-12 (eta p(2) = 0.094, p = 0.049), homocysteine (eta p(2) = 0.113, p = 0.022), vitamin C (eta p(2) = 0.140, p = 0.019), sodium (eta p(2) = 0.321, p = 0.000), potassium (eta p(2) 0.321, p = 0.006), knowledge (eta p(2) = 0.220, p = 0.001), and attitude (eta p(2) = 0.105, p = 0.040) in the intervention group over the control group. Individuals in the intervention group showed a significantly higher percentage of improvement in block design (+53.7%) compared to the control group (+8.0%), (p < 0.05).
   Conclusion: A 12-month educational intervention on nutritional, lifestyle, and cognitive exercise significantly improved nutritional status, knowledge, and attitude score. The study lacked power to demonstrate a statistically significant positive effect on cognitive functioning; thus, the preliminary findings should be confirmed in a larger trial. Copyright (C) 2014, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Johari, Sa'ida Munira; Shahar, Suzana; Rajikan, Roslee] Univ Kebangsaan Malaysia, Sch Healthcare Sci, Fac Hlth Sci, Dietet Program, Kuala Lumpur, Malaysia.
   [Ng, Tze Pin] Natl Univ Singapore Hosp, Dept Psychol Med, Singapore 117548, Singapore.
C3 Universiti Kebangsaan Malaysia; National University of Singapore
RP Shahar, S (corresponding author), Univ Kebangsaan Malaysia, Sch Healthcare Sci, Fac Hlth Sci, Dietet Program, Kuala Lumpur, Malaysia.
EM suzana.shahar@gmail.com
RI rajikan, roslee/J-2293-2017
OI Rajikan, Roslee/0000-0003-0572-2654
FU Universiti Kebangsaan Malaysia [UKM-GUP-SK-07-21-041]
FX This project was funded by UKM-GUP-SK-07-21-041 research grant,
   Universiti Kebangsaan Malaysia. The authors also acknowledge the
   invaluable assistance of co-researchers. Many thanks are extended to the
   patients, fieldworkers, and Clinical Trial Ward UKMMC staff.
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NR 63
TC 9
Z9 9
U1 1
U2 16
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD JUN
PY 2014
VL 8
IS 2
BP 74
EP 80
DI 10.1016/j.ijge.2013.07.002
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AL4FL
UT WOS:000339088200006
OA hybrid
DA 2023-08-17
ER

PT J
AU Tamura, MK
   Gaussoin, SA
   Pajewski, NM
   Chelune, GJ
   Freedman, BI
   Gure, TR
   Haley, WE
   Killeen, AA
   Oparil, S
   Rapp, SR
   Rifkin, DE
   Supiano, M
   Williamson, JD
   Weiner, DE
AF Kurella Tamura, Manjula
   Gaussoin, Sarah A.
   Pajewski, Nicholas M.
   Chelune, Gordon J.
   Freedman, Barry I.
   Gure, Tanya R.
   Haley, William E.
   Killeen, Anthony A.
   Oparil, Suzanne
   Rapp, Stephen R.
   Rifkin, Dena E.
   Supiano, Mark
   Williamson, Jeff D.
   Weiner, Daniel E.
TI Kidney Disease, Intensive Hypertension Treatment, and Risk for Dementia
   and Mild Cognitive Impairment: The Systolic Blood Pressure Intervention
   Trial
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
DE systolic blood pressure; Epidemiology and outcomes; glomerular
   filtration rate; hypertension
ID CLINICAL-TRIAL; RENAL-FUNCTION; HEALTH; ONSET; ORGAN
AB Background Intensively treating hypertension may benefit cardiovascular disease and cognitive function, but at the short-term expense of reduced kidney function.
   Methods We investigated markers of kidney function and the effect of intensive hypertension treatment on incidence of dementia and mild cognitive impairment (MCI) in 9361 participants in the randomized Systolic Blood Pressure Intervention Trial, which compared intensive versus standard systolic BP lowering (targeting <120 mm Hg versus <140 mm Hg, respectively). We categorized participants according to baseline and longitudinal changes in eGFR and urinary albumin-to-creatinine ratio. Primary outcomes were occurrence of adjudicated probable dementia and MCI.
   Results Among 8563 participants who completed at least one cognitive assessment during follow-up (median 5.1 years), probable dementia occurred in 325 (3.8%) and MCI in 640 (7.6%) participants. In multivariable adjusted analyses, there was no significant association between baseline eGFR <60 ml/min per 1.73m(2) and risk for dementia or MCI. In time-varying analyses, eGFR decline >= 30% was associated with a higher risk for probable dementia. Incident eGFR <60 ml/min per 1.73m(2) was associated with a higher risk for MCI and a composite of dementia or MCI. Although these kidney events occurred more frequently in the intensive treatment group, there was no evidence that they modified or attenuated the effect of intensive treatment on dementia and MCI incidence. Baseline and incident urinary ACR >= 30 mg/g were not associated with probable dementia or MCI, nor did the urinary ACR modify the effect of intensive treatment on cognitive outcomes.
   Conclusions Among hypertensive adults, declining kidney function measured by eGFR is associated with increased risk for probable dementia and MCI, independent of the intensity of hypertension treatment.
C1 [Kurella Tamura, Manjula] Palo Alto VA Hlth Care Syst, Geriatr Res & Educ Clin Ctr, Palo Alto, CA USA.
   [Kurella Tamura, Manjula] Stanford Univ, Sch Med, Div Nephrol, Palo Alto, CA 94304 USA.
   [Gaussoin, Sarah A.; Pajewski, Nicholas M.] Wake Forest Sch Med, Dept Biostat & Data Sci, Winston Salem, NC 27101 USA.
   [Chelune, Gordon J.] Univ Utah, Sch Med, Ctr Alzheimers Care Imaging & Res, Salt Lake City, UT USA.
   [Freedman, Barry I.] Wake Forest Sch Med, Dept Internal Med, Sect Nephrol, Winston Salem, NC 27101 USA.
   [Gure, Tanya R.] Ohio State Univ, Div Gen Internal Med & Geriatr, Columbus, OH 43210 USA.
   [Haley, William E.] Mayo Clin, Div Nephrol & Hypertens, Jacksonville, FL 32224 USA.
   [Killeen, Anthony A.] Univ Minnesota, Dept Lab Med, Minneapolis, MN 55455 USA.
   [Killeen, Anthony A.] Univ Minnesota, Dept Pathol, Minneapolis, MN 55455 USA.
   [Oparil, Suzanne] Univ Alabama Birmingham, Div Cardiovasc Dis, Vasc Biol & Hypertens Program, Birmingham, AL USA.
   [Rapp, Stephen R.] Wake Forest Sch Med, Dept Psychiat & Behav Med, Winston Salem, NC 27101 USA.
   [Rifkin, Dena E.] Univ Calif San Diego, Div Nephrol, La Jolla, CA 92093 USA.
   [Supiano, Mark] Univ Utah, Sch Med, Div Geriatr, Salt Lake City, UT USA.
   [Williamson, Jeff D.] Wake Forest Sch Med, Sticht Ctr Hlth Aging & Alzheimers Prevent, Winston Salem, NC USA.
   [Williamson, Jeff D.] Wake Forest Sch Med, Div Geriatr Med, Winston Salem, NC USA.
   [Weiner, Daniel E.] Tufts Med Ctr, Div Nephrol, Boston, MA 02111 USA.
C3 Geriatric Research Education & Clinical Center; Stanford University;
   Wake Forest University; Utah System of Higher Education; University of
   Utah; Wake Forest University; University System of Ohio; Ohio State
   University; Mayo Clinic; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; University of Alabama System; University of
   Alabama Birmingham; Wake Forest University; University of California
   System; University of California San Diego; Utah System of Higher
   Education; University of Utah; Wake Forest University; Wake Forest
   University; Tufts Medical Center
RP Tamura, MK (corresponding author), Vet Affairs Palo Alto Hlth Care Syst, 3801 Miranda Ave, Palo Alto, CA 94304 USA.
RI Killeen, Anthony A/E-4697-2010; Rapp, Stephen R/J-3367-2016; Pajewski,
   Nicholas/J-1096-2019; Tamura, Manjula Kurella/C-8284-2014
OI Killeen, Anthony A/0000-0003-1629-9468; Tamura, Manjula
   Kurella/0000-0001-5227-2479; Supiano, Mark/0000-0002-5438-5087; haley,
   william/0000-0002-5312-8660
FU National Institutes of Health (NIH) [R01DK092241, R01AG055606];
   Alzheimer's Association; Federal funds from the NIH, including the
   National Heart, Lung, and Blood Institute; National Institute of
   Diabetes and Digestive and Kidney Diseases; National Institute on Aging;
   National Institute of Neurological Disorders and Stroke
   [HHSN268200900040C, HHSN268200900046C, HHSN268200900047C,
   HHSN268200900048C, HHSN268200900049C, A-HL-13-002-001]
FX This study was supported by National Institutes of Health (NIH) grants
   R01DK092241 (to M. Kurella Tamura) and R01AG055606 (to PI: Dr.
   Reboussin), as well as funding from the Alzheimer's Association (to J.D.
   Williamson). The Systolic Blood Pressure Intervention Trial is funded
   with Federal funds from the NIH, including the National Heart, Lung, and
   Blood Institute, the National Institute of Diabetes and Digestive and
   Kidney Diseases, the National Institute on Aging, and the National
   Institute of Neurological Disorders and Stroke, under contract numbers
   HHSN268200900040C, HHSN268200900046C, HHSN268200900047C,
   HHSN268200900048C, and HHSN268200900049C, and interagency agreement
   number A-HL-13-002-001.
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NR 28
TC 20
Z9 20
U1 0
U2 5
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD SEP
PY 2020
VL 31
IS 9
BP 2122
EP 2132
DI 10.1681/ASN.2020010038
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA NR8KY
UT WOS:000571810200015
PM 32591439
OA Bronze, Green Published
DA 2023-08-17
ER

PT J
AU Bayliss, EA
   Shetterly, SM
   Drace, ML
   Norton, J
   Green, AR
   Reeve, E
   Weffald, LA
   Wright, L
   Maciejewski, ML
   Sheehan, OC
   Wolff, JL
   Gleason, KS
   Kraus, C
   Maiyani, M
   Du Vall, M
   Boyd, CM
AF Bayliss, E. A.
   Shetterly, S. M.
   Drace, M. L.
   Norton, J.
   Green, A. R.
   Reeve, E.
   Weffald, L. A.
   Wright, L.
   Maciejewski, M. L.
   Sheehan, O. C.
   Wolff, J. L.
   Gleason, K. S.
   Kraus, C.
   Maiyani, M.
   Du Vall, M.
   Boyd, C. M.
TI The OPTIMIZE patient- and family-centered, primary care-based
   deprescribing intervention for older adults with dementia or mild
   cognitive impairment and multiple chronic conditions: study protocol for
   a pragmatic cluster randomized controlled trial
SO TRIALS
LA English
DT Article
DE Polypharmacy; Multimorbidity; Deprescribing; Dementia
ID ALZHEIMERS-DISEASE; DRUG-USE; HEALTH; POLYPHARMACY; MEDICATIONS;
   ATTITUDES; PEOPLE; HOSPITALIZATIONS; PERCEPTIONS; WITHDRAWAL
AB Background Most individuals with dementia or mild cognitive impairment (MCI) have multiple chronic conditions (MCC). The combination leads to multiple medications and complex medication regimens and is associated with increased risk for significant treatment burden, adverse drug events, cognitive changes, hospitalization, and mortality. Optimizing medications through deprescribing (the process of reducing or stopping the use of inappropriate medications or medications unlikely to be beneficial) may improve outcomes for MCC patients with dementia or MCI. Methods With input from patients, family members, and clinicians, we developed and piloted a patient-centered, pragmatic intervention (OPTIMIZE) to educate and activate patients, family members, and primary care clinicians about deprescribing as part of optimal medication management for older adults with dementia or MCI and MCC. The clinic-based intervention targets patients on 5 or more medications, their family members, and their primary care clinicians using a pragmatic, cluster-randomized design at Kaiser Permanente Colorado. The intervention has two components: a patient/ family component focused on education and activation about the potential value of deprescribing, and a clinician component focused on increasing clinician awareness about options and processes for deprescribing. Primary outcomes are total number of chronic medications and total number of potentially inappropriate medications (PIMs). We estimate that approximately 2400 patients across 9 clinics will receive the intervention. A comparable number of patients from 9 other clinics will serve as wait-list controls. We have > 80% power to detect an average decrease of - 0.70 (< 1 medication). Secondary outcomes include the number of PIM starts, dose reductions for selected PIMs (benzodiazepines, opiates, and antipsychotics), rates of adverse drug events (falls, hemorrhagic events, and hypoglycemic events), ability to perform activities of daily living, and skilled nursing facility, hospital, and emergency department admissions. Discussion The OPTIMIZE trial will examine whether a primary care-based, patient- and family-centered intervention educating patients, family members, and clinicians about deprescribing reduces numbers of chronic medications and PIMs for older adults with dementia or MCI and MCC.
C1 [Bayliss, E. A.; Shetterly, S. M.; Drace, M. L.; Wright, L.; Sheehan, O. C.; Gleason, K. S.; Kraus, C.; Maiyani, M.] Kaiser Permanente Colorado, Inst Hlth Res, Aurora, CO 80045 USA.
   [Bayliss, E. A.] Univ Colorado, Dept Family Med, Sch Med, Aurora, CO USA.
   [Norton, J.; Green, A. R.; Boyd, C. M.] Johns Hopkins Univ, Div Geriatr Med & Gerontol, Sch Med, Baltimore, MD USA.
   [Reeve, E.] Univ South Australia, Qual Use Med & Pharm Res Ctr, UniSA Clin & Hlth Sci, Adelaide, SA, Australia.
   [Reeve, E.] Dalhousie Univ, Fac Med, Geriatr Med Res, Halifax, NS, Canada.
   [Reeve, E.] Dalhousie Univ, Coll Pharm, Halifax, NS, Canada.
   [Reeve, E.] Nova Scotia Hlth Author, Halifax, NS, Canada.
   [Weffald, L. A.; Du Vall, M.] Kaiser Permanente Colorado, Dept Clin Pharm, Aurora, CO USA.
   [Maciejewski, M. L.] Vet Affairs Med Ctr, Durham Ctr Innovat Accelerate Discovery & Practic, Durham, NC USA.
   [Maciejewski, M. L.] Duke Univ, Dept Populat Hlth Sci, Med Ctr, Durham, NC USA.
   [Wolff, J. L.] Johns Hopkins Sch Med, Sch Publ Hlth, Baltimore, MD USA.
C3 Kaiser Permanente; University of Colorado System; University of Colorado
   Anschutz Medical Campus; Johns Hopkins University; University of South
   Australia; Dalhousie University; Dalhousie University; Kaiser
   Permanente; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Duke University; Johns Hopkins University; Johns
   Hopkins Medicine
RP Bayliss, EA (corresponding author), Kaiser Permanente Colorado, Inst Hlth Res, Aurora, CO 80045 USA.
EM Elizabeth.Bayliss@kp.org
RI Reeve, Emily/AFL-3604-2022
OI Reeve, Emily/0000-0002-1405-999X; Norton, Jonathan/0000-0003-0044-7163
FU National Institute on Aging [R33-AG057289]
FX National Institute on Aging (R33-AG057289). The funder had no role in
   the study design, data collection or analysis, data interpretation, or
   writing the manuscript.
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NR 60
TC 19
Z9 19
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUN 18
PY 2020
VL 21
IS 1
AR 542
DI 10.1186/s13063-020-04482-0
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA MC6QT
UT WOS:000543409700001
PM 32552857
OA Green Accepted, gold, Green Published
DA 2023-08-17
ER

PT J
AU Yang, SY
   Lin, YC
   Lee, YC
   Hsieh, PL
   Lin, YL
AF Yang, Shang -Yu
   Lin, Yu -Chen
   Lee, Ya-Chen
   Hsieh, Pei-Lun
   Lin, Ying-Lien
TI Board Game Intervention to Improve Cognitive and Daily Functioning in
   Elderly People with Mild Cognitive Impairment: A Randomized Controlled
   Trial
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Article
DE board game; cognitive functioning; daily functioning; mild cognitive
   impairment
ID INSTRUMENTAL ACTIVITIES; OLDER-ADULTS; DEMENTIA; MCI
AB Objective: To examine the effectiveness of a 12-week board game intervention for seniors with mild cognitive impairment (MCI) in improving cognitive functioning and scores on the instrumental activities of daily living (IADL) scale.Methods: A single-blind randomized controlled trial was conducted to collect data from a long-term care facility in central Taiwan. Sixty-eight MCI seniors were recruited and randomized into a board game group (trial group) and a health promotion group (control group). Participants in both groups received a 2-hour intervention once a week for 12 weeks, with the trial group receiving 12 weeks of board games and the control group receiving 12 weeks of health promotion activities. Before and after the inter-vention, the primary assessment was conducted using the Saint Louis University Mental Status Exam, Contextual Memory Test, and Trail Making Test part-A; the secondary assessment was conducted using the IADL scale.Results: The results of the primary assessment indicated that the participants in the trial group showed significant differences in immediate recall and delayed recall compared to the control group (p < 0.01). The results of the secondary assessment indicated that participants in the trial group differed signifi-cantly (p < 0.01) only on the item of using the telephone compared to the control group.Conclusions: Compared to the health-promoted MCI seniors, those who participated in the board game had significant improvements in memory (immediate recall and delayed recall), but not in IADL (except for using the telephone).Copyright (c) 2022, Taiwan Society of Geriatric Emergency & Critical Care Medicine.
C1 [Yang, Shang -Yu; Lin, Yu -Chen] Asia Univ, Coll Med & Hlth Sci, Dept Healthcare Adm, 500 Lioufeng Rd, Taichung 41354, Taiwan.
   [Lee, Ya-Chen] Asia Univ, Coll Med & Hlth Sci, Dept Occupat Therapy, Taichung, Taiwan.
   [Hsieh, Pei-Lun] Natl Taichung Univ Sci & Technol, Coll Hlth, Dept Nursing, Taichung, Taiwan.
   [Lin, Ying-Lien] Natl Cheng Kung Univ, Dept Ind & Informat Management, Tainan, Taiwan.
C3 Asia University Taiwan; Asia University Taiwan; National Taichung
   University of Science & Technology; National Cheng Kung University
RP Yang, SY (corresponding author), Asia Univ, Coll Med & Hlth Sci, Dept Healthcare Adm, 500 Lioufeng Rd, Taichung 41354, Taiwan.
EM henry879019@yahoo.com.tw
FU Ministry of Scienceand Technology, Taiwan;  [MOST
   109-2314-B-468-009-MY2]
FX Acknowledgments This work was funded by grants from the Ministry of
   Scienceand Technology, Taiwan (grant no. MOST 109-2314-B-468-009-MY2) .
   We thank all the participants and research assistants for their
   contribution to the study.
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NR 40
TC 0
Z9 0
U1 7
U2 9
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD OCT
PY 2022
VL 16
IS 4
BP 348
EP 354
DI 10.6890/IJGE.202210_16(4).0007
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 6L2OL
UT WOS:000888027600008
DA 2023-08-17
ER

PT J
AU Rondao, CAD
   Mota, MPG
   Esteves, D
AF Rondao, Catarina Alexandra de Melo
   Mota, Maria Paula Goncalves
   Esteves, Dulce
TI Development of a Combined Exercise and Cognitive Stimulation
   Intervention for People with Mild Cognitive Impairment-Designing the
   MEMO_MOVE PROGRAM
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE exercise program design; multimodal exercise for MCI; dementia; exercise
   characteristics for MCI; dementia
ID NURSING-HOME RESIDENTS; DWELLING OLDER-ADULTS; PHYSICAL-EXERCISE;
   ALZHEIMERS-DISEASE; AEROBIC EXERCISE; NEUROTROPHIC FACTOR; IMPROVE
   COGNITION; VASCULAR HEALTH; EARLY DEMENTIA; GAIT
AB Dementia patients are at high risk for the decline of both physical and cognitive capacities, resulting in an increased risk of the loss of autonomy. Exercise is regarded as a non-pharmacological therapy for dementia, considering the potential benefits of preventing cognitive decline and improving physical fitness. In this paper, we aim to describe the different design stages for an exercise program combined with cognitive stimulation for a population with mild cognitive impairment, i.e., the MEMO_MOVE program. Methods: The intervention design followed the Medical Research Council's guidelines for complex interventions and was structured according to the six steps in quality intervention development (6SQuID). The intervention was described considering the Template for Intervention Description and Replication (TIDieR). In order to establish the intervention characteristics, a literature review was conducted to collate and analyze previous work, which provided a summary the type of exercise that should be implemented among this population. Results: The MEMO_MOVE program was structured and described, regarding (i) inclusion of a cognitive stimulation component; (ii) the kind of cognitive stimulation; and (iii) the type of exercise, duration, frequency, intensity, and program length. Conclusions: A systematic step-by-step process design was followed to create a specific intervention to promote physical fitness and cognitive stimulation in individuals with mild dementia.
C1 [Rondao, Catarina Alexandra de Melo; Esteves, Dulce] Univ Beira Interior, Dept Sports, P-6201001 Covilha, Portugal.
   [Rondao, Catarina Alexandra de Melo] Fdn City Council, P-6230338 Fundao, Portugal.
   [Mota, Maria Paula Goncalves; Esteves, Dulce] Res Ctr Sports Sci Hlth Sci & Human Dev CIDESD, P-5001801 Vila Real, Portugal.
   [Mota, Maria Paula Goncalves] Univ Tras Os Montes & Alto Douro, Dept Sports, P-5000801 Vila Real, Portugal.
C3 Universidade da Beira Interior; University of Tras-os-Montes & Alto
   Douro
RP Rondao, CAD; Esteves, D (corresponding author), Univ Beira Interior, Dept Sports, P-6201001 Covilha, Portugal.; Rondao, CAD (corresponding author), Fdn City Council, P-6230338 Fundao, Portugal.; Esteves, D (corresponding author), Res Ctr Sports Sci Hlth Sci & Human Dev CIDESD, P-5001801 Vila Real, Portugal.
EM cr.sport11@gmail.com; desteves@ubi.pt
OI Esteves, Dulce/0000-0002-6368-2577; Rondao, Catarina/0000-0002-1204-2473
FU  [NORTE-01-0145-FEDER-000083]
FX This work was supported by CIDESD (NORTE-01-0145-FEDER-000083).
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NR 106
TC 1
Z9 1
U1 11
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2022
VL 19
IS 16
AR 10221
DI 10.3390/ijerph191610221
PG 19
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 4C6VB
UT WOS:000846587200001
PM 36011852
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Torpil, B
   Pekcetin, E
   Pekcetin, S
AF Torpil, Berkan
   Pekcetin, Emel
   Pekcetin, Serkan
TI The effectiveness of cognitive rehabilitation intervention with the
   telerehabilitation method for amnestic mild cognitive impairment: A
   feasibility randomized controlled trial
SO JOURNAL OF TELEMEDICINE AND TELECARE
LA English
DT Article; Early Access
DE Telerehabilitation; telemedicine; cognitive skills; mild cognitive
   impairment; rehabilitation
ID ALZHEIMERS-DISEASE
AB Introduction Although different cognitive rehabilitation (CR) approaches have been developed for mild cognitive impairment (MCI), a standard method has not been determined for interventions, especially with the telerehabilitation (TR) method, which is one of the alternative solutions to the problems of accessing rehabilitation services. The study was planned to compare the effectiveness of the CR intervention applied in the older adults with amnestic-MCI with face-to-face and TR methods. Methods A total of 68 participants were randomly assigned to the TR and face-to-face groups. TR method was delivered by teleconference method in the participant's own home. A 12-week CR intervention was applied to both groups. Pre- and post-intervention cognitive skills of the participants were evaluated using the Loewenstein occupational therapy cognitive assessment-geriatric (LOTCA-G). Results Cognitive skills were increased in both groups (p < 0.001). A statistically significant difference was observed between the groups in the post-intervention visual-spatial perception, praxis, and total LOTCA-G scores (p < 0.01). Discussion It was determined that a 12-week CR program had positive effects on cognitive functions in the older adults with amnestic MCI. Both TR and face-to-face methods can be used in CR interventions for amnestic MCI. In addition, the TR method can be advantageous in terms of time and accessibility.
C1 [Torpil, Berkan; Pekcetin, Serkan] Univ Hlth Sci Turkey, Fac Gulhane Hlth Sci, Dept Occupat Therapy, TR-34668 Ankara, Turkiye.
   [Pekcetin, Emel] Hacettepe Univ, Fac Hlth Sci, Dept Occupat Therapy, Ankara, Turkiye.
C3 Hacettepe University
RP Torpil, B (corresponding author), Univ Hlth Sci Turkey, Fac Gulhane Hlth Sci, Dept Occupat Therapy, TR-34668 Ankara, Turkiye.
EM berkantorpil@gmail.com
RI Torpil, Berkan/AAQ-6758-2021
OI Torpil, Berkan/0000-0002-0322-5163
CR Marzaleh MA, 2022, DISASTER MED PUBLIC, V17, DOI 10.1017/dmp.2022.219
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NR 36
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1357-633X
EI 1758-1109
J9 J TELEMED TELECARE
JI J. Telemed. Telecare
PD 2023 AUG 3
PY 2023
DI 10.1177/1357633X231189541
EA AUG 2023
PG 8
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA O2SG6
UT WOS:001042363900001
PM 37537894
DA 2023-08-17
ER

PT J
AU Kim, HH
   Jung, NH
AF Kim, Hwan-Hee
   Jung, Nam-Hae
TI Effects of Assistive Technology Application in Dementia Intervention for
   People with Mild Cognitive Impairment & Mild Alzheimer Type Dementia and
   Caregiver
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID CARE; ASSOCIATION; ANXIETY
AB Background . Dementia, a degenerative disease, requires alternative treatment to maintain function, but previous studies suggest only the therapeutic effect of a temporary program.
   Primary Study Objective . The current study aimed to examine the effects of assistive technologies on cognitive function, daily living ability, and psychosocial symptoms in elderlies with mild cognitive impairment, elderlies with mild dementia and their caregivers.
   Design . The research team designed an experimental study that used application as the intervention.
   Setting . To recruit participants living in the local community, research participation was supported through local public health centers, welfare centers, and social welfare organizations. Evaluation and intervention were conducted by visiting the participant's home.
   Participant . The study participants were 29 Mild Cognitive Impairment (MCI) and 16 mild Alzheimer type dementia (AD) patients over the age of 75 with a total of 45 patients, 10 MCI caregivers and 11 AD caregivers with a total of 21 caregivers.
   Intervention . The assistive technologies used for intervention are 3 area (8 daily living assistive devices, 7 safety assistive technologies, and 7 cognitive assistive technologies). Up to 5 assistive technologies were provided to one subject, and they were instructed to use them every day for 8 weeks.
   Outcome measure . Participants were evaluated at baseline and postintervention using specific scales appropriate to an area: cognitive function, activities of daily living, depression, anxiety, quality of life, satisfaction.
   Results . Cognitive function showed statistically significant changes in the MCI group. Basic activities of daily living, depression, anxiety, quality of life, satisfaction showed statistically significant positive effects in both MCI and AD groups. Instrumental activities of daily living did not show any statistically significant differences.
   Conclusion . As an alternative to dementia care in the future, the application and management of assistive technologies for each area should be provided at the government level. (Altern Ther Health Med. 2023;29(2):104111)
C1 [Kim, Hwan-Hee] Semyung Univ, Dept Occupat Therapy, Jecheon, Chungbuk, South Korea.
   [Jung, Nam-Hae] Dongseo Univ, Dept Occupat Therapy, Busan, South Korea.
C3 Semyung University; Dongseo University
RP Jung, NH (corresponding author), Dongseo Univ, Dept Occupat Therapy, Busan, South Korea.
EM ot123443@dongseo.ac.kr
FU National Research Foundation of Korea [2018R1C1B5045630]; National
   Research Foundation of Korea [2018R1C1B5045630] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
FX This research was supported by National Research Foundation of Korea
   (2018R1C1B5045630).
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NR 51
TC 0
Z9 0
U1 1
U2 1
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD MAR
PY 2023
VL 29
IS 2
BP 104
EP 111
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA D4MS0
UT WOS:000968494500015
PM 35751894
DA 2023-08-17
ER

PT J
AU Butler, M
   Nelson, VA
   Davila, H
   Ratner, E
   Fink, HA
   Hemmy, LS
   McCarten, JR
   Barclay, TR
   Brasure, M
   Kane, RL
AF Butler, Mary
   Nelson, Victoria A.
   Davila, Heather
   Ratner, Edward
   Fink, Howard A.
   Hemmy, Laura S.
   McCarten, J. Riley
   Barclay, Terry R.
   Brasure, Michelle
   Kane, Robert L.
TI Over-the-Counter Supplement Interventions to Prevent Cognitive Decline,
   Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia A
   Systematic Review
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Review
ID SOY ISOFLAVONE SUPPLEMENTATION; PLACEBO-CONTROLLED TRIAL; GINKGO-BILOBA
   EXTRACT; DOUBLE-BLIND; OLDER-ADULTS; B-VITAMINS; POSTMENOPAUSAL WOMEN;
   FATTY-ACIDS; FISH-OIL; PERFORMANCE
AB Background: Optimal interventions to prevent or delay cognitive decline, mild cognitive impairment (MCI), or dementia are uncertain.
   Purpose: To summarize the evidence on efficacy and harms of over-the-counter (OTC) supplements to prevent or delay cognitive decline, MCI, or clinical Alzheimer-type dementia in adults with normal cognition or MCI but no dementia diagnosis.
   Data Sources: Multiple electronic databases from 2009 to July 2017 and bibliographies of systematic reviews.
   Study Selection: English-language trials of at least 6 months' duration that enrolled adults without dementia and compared cognitive outcomes with an OTC supplement versus placebo or active controls.
   Data Extraction: Extraction performed by a single reviewer and confirmed by a second reviewer; dual-reviewer assessment of risk of bias; consensus determination of strength of evidence.
   Data Synthesis: Thirty-eight trials with low to medium risk of bias compared omega-3 fatty acids, soy, ginkgo biloba, B vitamins, vitamin D plus calcium, vitamin C or beta-carotene, multi-ingredient supplements, or other OTC interventions with placebo or other supplements. Few studies examined effects on clinical Alzheimer-type dementia or MCI, and those that did suggested no benefit. Daily folic acid plus vitamin B-12 was associated with improvements in performance on some objectively measured memory tests that were statistically significant but of questionable clinical significance. Moderate-strength evidence showed that vitamin E had no benefit on cognition. Evidence about effects of omega-3 fatty acids, soy, ginkgo biloba, folic acid alone or with other B vitamins, beta-carotene, vitamin C, vitamin D plus calcium, and multivitamins or multi-ingredient supplements was either insufficient or low-strength, suggesting that these supplements did not reduce risk for cognitive decline. Adverse events were rarely reported.
   Limitation: Studies had high attrition and short follow-up and used a highly variable set of cognitive outcome measures.
   Conclusion: Evidence is insufficient to recommend any OTC supplement for cognitive protection in adults with normal cognition or MCI.
C1 [Butler, Mary; Nelson, Victoria A.; Davila, Heather; Brasure, Michelle] Univ Minnesota, Div Hlth Policy & Management, 420 Delaware St Southeast,Mayo Mem Bldg D351, Minneapolis, MN 55455 USA.
   [Ratner, Edward; Fink, Howard A.; Hemmy, Laura S.; McCarten, J. Riley] Minneapolis VA Hlth Care Syst, Geriatr Res Educ & Clin Ctr, One Vet Dr,11-G, Minneapolis, MN 55417 USA.
   HealthPartners, Minneapolis, MN USA.
   [Barclay, Terry R.] Univ Minnesota, Dept Neurol, 295 Phalen Blvd,Mailstop 41203C, St Paul, MN 55130 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Geriatric Research Education & Clinical Center; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Minneapolis VA
   Health Care System; University of Minnesota System; University of
   Minnesota Twin Cities
RP Butler, M (corresponding author), Univ Minnesota, Div Hlth Policy & Management, 420 Delaware St Southeast,Mayo Mem Bldg D351, Minneapolis, MN 55455 USA.
EM butl0092@umn.edu
RI Fink, Howard A/F-3933-2012
OI Davila, Heather/0000-0003-1832-7901
FU Agency for Healthcare Research and Quality [290-2015-00008-I]
FX This manuscript is based on research conducted by the Minnesota
   Evidence-based Practice Center under AHRQ contract 290-2015-00008-I.
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NR 57
TC 81
Z9 84
U1 0
U2 46
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD JAN 2
PY 2018
VL 168
IS 1
BP 52
EP +
DI 10.7326/M17-1530
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FR5SO
UT WOS:000419126700007
PM 29255909
DA 2023-08-17
ER

PT J
AU Chandler, MJ
   Locke, DE
   Crook, JE
   Fields, JA
   Ball, CT
   Phatak, VS
   Dean, PM
   Morris, M
   Smith, GE
AF Chandler, Melanie J.
   Locke, Dona E.
   Crook, Julia E.
   Fields, Julie A.
   Ball, Colleen T.
   Phatak, Vaishali S.
   Dean, Pamela M.
   Morris, Miranda
   Smith, Glenn E.
TI Comparative Effectiveness of Behavioral Interventions on Quality of Life
   for Older Adults With Mild Cognitive Impairment A Randomized Clinical
   Trial
SO JAMA NETWORK OPEN
LA English
DT Article
AB IMPORTANCE Recommendations to engage in behavioral strategies to combat clinically significant cognitive and behavioral symptoms are routinely given to persons with mild cognitive impairment (MCI). The comparative effectiveness of these behavioral interventions is not well understood.
   OBJECTIVE To compare the incremental effects of combinations of 5 behavioral interventions on outcomes of highest importance to patients with MCI.
   DESIGN, SETTING, AND PARTICIPANTS In this multisite, cluster randomized, multicomponent comparative effectiveness trial, 272 patients from 4 academic medical outpatient centers (Mayo Clinic, Rochester, Minnesota; Mayo Clinic, Scottsdale, Arizona; Mayo Clinic, Jacksonville, Florida; and University of Washington, Seattle) were recruited from September 1, 2014, to August 31, 2016, with last follow-up March 31, 2019. All participants met the National Institute on Aging-Alzheimer's Association criteria for MCI.
   INTERVENTIONS The intervention program was modeled on the Mayo Clinic Healthy Action to Benefit Independence and Thinking (HABIT) program, a 50-hour group intervention conducted during 2 weeks, including memory compensation training, computerized cognitive training, yoga, patient and partner support groups, and wellness education. In our study, 1 of 5 interventions was randomly selected to be withheld for each intervention group. Participants and their partners had 1-day booster sessions at 6 and 12 months after intervention.
   MAIN OUTCOMES AND MEASURES Quality-of-life measurement of participants with MCI at 12 months was the primary outcome, selected based on the preference rankings of previous program participants. Mood, self-efficacy, and memory-based activities of daily living were also highly ranked.
   RESULTS A total of 272 participants (mean [SD] age, 75 [8] years; 160 [58.8%] male and 112 [41.2%] female) were enrolled in this study, with 56 randomized to the no yoga group, 54 to no computerized cognitive training, 52 to no wellness, 53 to no support, and 57 to no memory support system. The greatest effect size for quality of life was between the no computerized cognitive training and no wellness education groups at 0.34 (95% CI, 0.05-0.64). In secondary analyses, wellness education had a greater effect on mood than computerized cognitive training (effect size, 0.53; 95% CI, 0.21-0.86), and yoga had a greater effect on memory-related activities of daily living than support groups (effect size, 0.43; 95% CI, 0.13-0.72).
   CONCLUSIONS AND RELEVANCE These results provide further support for behavioral interventions for persons with MCI. Different outcomes were optimized by different combinations of interventions. These findings provide an initial exploration of the effect of behavioral interventions on patient-advocated outcomes in persons with MCI.
C1 [Chandler, Melanie J.] Mayo Clin, Div Psychol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
   [Locke, Dona E.] Mayo Clin, Div Psychol, Scottsdale, AZ USA.
   [Crook, Julia E.; Ball, Colleen T.] Mayo Clin, Div Biomed Stat & Informat, Jacksonville, FL 32224 USA.
   [Fields, Julie A.] Mayo Clin, Div Neurocognit Disorders, Rochester, MN USA.
   [Phatak, Vaishali S.] Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE USA.
   [Phatak, Vaishali S.; Dean, Pamela M.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Morris, Miranda] Mayo Clin, Hlth Studies Unit, Jacksonville, FL 32224 USA.
   [Smith, Glenn E.] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic Phoenix; Mayo Clinic; Mayo Clinic;
   University of Nebraska System; University of Nebraska Medical Center;
   University of Washington; University of Washington Seattle; Mayo Clinic;
   State University System of Florida; University of Florida
RP Chandler, MJ (corresponding author), Mayo Clin, Div Psychol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
EM chandler.melanie@mayo.edu
FU PCORI [CER-1306-01897]
FX Research reported in this article was primarily funded through PCORI
   award CER-1306-01897.
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NR 27
TC 38
Z9 39
U1 3
U2 18
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD MAY
PY 2019
VL 2
IS 5
AR e193016
DI 10.1001/jamanetworkopen.2019.3016
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IK7XE
UT WOS:000476806200010
PM 31099860
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Chan, JSY
   Wu, JM
   Deng, KF
   Yan, JH
AF Chan, John S. Y.
   Wu, Jiamin
   Deng, Kanfeng
   Yan, Jin H.
TI The effectiveness of dance interventions on cognition in patients with
   mild cognitive impairment: A meta-analysis of randomized controlled
   trials
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Article
DE Cognition; Dance; Meta-analysis; Mild cognitive impairment; Randomized
   controlled trials
ID OLDER-ADULTS; INSTRUMENTAL ACTIVITIES; PHYSICAL-ACTIVITY; PEDRO SCALE;
   EXERCISE; PLASTICITY; HIPPOCAMPUS; PERFORMANCE; MANAGEMENT; DEMENTIA
AB This meta-analysis of randomized controlled trials (published or unpublished RCTs in English) examined the effectiveness of dance interventions compared to waitlist/active controls on cognitive functions in patients with mild cognitive impairment (MCI). Literature search was conducted on MEDLINE, EMBASE, CINAHL and related databases through 3 August 2019. Risk of bias was assessed with the PEDro scale regarding randomization, allocation concealment, group comparability, blinding, attrition and selective reporting. Five included RCTs (N = 358) used Latin, ballroom and aerobic dances (frequency: 1-3 session/week; intensity: light to moderate; time: 25-60 min/session; type: aerobic). Results show that dance interventions improve global cognition (SMD [95 % CI] = 0.48 [0.21, 0.74]), attention (SMD [95 % CI] = 0.33 [0.12, 0.54]), immediate (SMD [95 % CI] = 0.54 [0.38, 0.71]) and delayed recall (SMD [95 % CI] = 0.33 [0.01, 0.64]), and visuospatial ability (SMD [95 % CI] = 0.16 [0.01, 0.32]). Study limitations include a small number of RCTs and high heterogeneity in some cognitive domains. In summary, dance interventions improve some cognitive domains in MCI.
C1 [Chan, John S. Y.; Wu, Jiamin; Deng, Kanfeng; Yan, Jin H.] Shenzhen Univ, Lab Neuromotor Control & Learning, 3688 Nan Hai Ave, Shenzhen 518060, Guangdong, Peoples R China.
C3 Shenzhen University
RP Yan, JH (corresponding author), Shenzhen Univ, Lab Neuromotor Control & Learning, 3688 Nan Hai Ave, Shenzhen 518060, Guangdong, Peoples R China.
EM j-h-yan@qq.com
OI Chan, John/0000-0003-0265-3147
FU Basic Research of Knowledge Innovation Program of Shenzhen
   [JCYJ20190808115817044]
FX This work was supported by the Basic Research of Knowledge Innovation
   Program of Shenzhen to JHY [grant number JCYJ20190808115817044].
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NR 61
TC 14
Z9 15
U1 5
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD NOV
PY 2020
VL 118
BP 80
EP 88
DI 10.1016/j.neubiorev.2020.07.017
PG 9
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA QK1TN
UT WOS:000620164200007
PM 32687886
DA 2023-08-17
ER

PT J
AU Regan, B
   Varanelli, L
AF Regan, Bridget
   Varanelli, Laura
TI A systematic review of psychological intervention studies in Mild
   Cognitive Impairment and early dementia: impact on adjustment,
   depression and anxiety
SO AUSTRALASIAN JOURNAL ON AGEING
LA English
DT Meeting Abstract
C1 [Regan, Bridget] Monash Univ, Monash Ageing Res Ctr, Melbourne, Vic 3004, Australia.
   [Regan, Bridget] Monash Hlth, Melbourne, Vic, Australia.
   [Regan, Bridget; Varanelli, Laura] La Trobe Univ, Lincoln Ctr Res Ageing, Melbourne, Vic, Australia.
C3 Monash University; La Trobe University
NR 0
TC 0
Z9 0
U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-6381
EI 1741-6612
J9 AUSTRALAS J AGEING
JI Australas. Ageing
PD JUN
PY 2014
VL 33
SU 1
SI SI
MA FP19
BP 60
EP 60
PG 1
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AJ8PT
UT WOS:000337969400115
DA 2023-08-17
ER

PT J
AU Di Lorito, C
   Bosco, A
   Rai, H
   Craven, M
   McNally, D
   Todd, C
   Booth, V
   Cowley, A
   Howe, L
   Harwood, RH
AF Di Lorito, Claudio
   Bosco, Alessandro
   Rai, Harleen
   Craven, Michael
   McNally, Donal
   Todd, Chris
   Booth, Vicky
   Cowley, Alison
   Howe, Louise
   Harwood, Rowan H.
TI A systematic literature review and meta-analysis on digital health
   interventions for people living with dementia and Mild Cognitive
   Impairment
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE dementia; digital health; effectiveness; information technology;
   literature review; meta-analysis; Mild Cognitive Impairment;
   rehabilitation
ID ALZHEIMERS-DISEASE; OLDER-ADULTS; FALLS; BALANCE; CARE; PROGRAM;
   TELEREHABILITATION; TECHNOLOGIES; FEASIBILITY; TELEHEALTH
AB Objectives: Digital health interventions enable services to support people living with dementia and Mild Cognitive Impairment (MCI) remotely. This literature review gathers evidence on the effectiveness of digital health interventions on physical, cognitive, behavioural and psychological outcomes, and Activities of Daily Living in people living with dementia and MCI.
   Methods/Design: Searches, using nine databases, were run in November 2021. Two authors carried out study selection/appraisal using the Critical Appraisal Skills Programme checklist. Study characteristics were extracted through the Cochrane handbook for systematic reviews of interventions data extraction form. Data on digital health interventions were extracted through the template for intervention description and replication (TIDieR) checklist and guide. Intervention effectiveness was determined through effect sizes. Meta-analyses were performed to pool data on intervention effectiveness.
   Results: Twenty studies were included in the review, with a diverse range of interventions, modes of delivery, activities, duration, length, frequency, and intensity. Compared to controls, the interventions produced a moderate effect on cognitive abilities (SMD = 0.36; 95% CI = -0.03 to 0.76; I-2 = 61%), and a negative moderate effect on basic ADLs (SMD = -0.40; 95% CI = -0.86 to 0.05; I-2 = 69%). Stepping exergames generated the largest effect sizes on physical and cognitive abilities. Supervised training produced larger effect sizes than unsupervised interventions.
   Conclusion: Supervised intervention delivery is linked to greatest benefits. A mix of remote and face-to-face delivery could maximise benefits and optimise costs. Accessibility, acceptability and sustainability of digital interventions for end-users must be pre-requisites for the development of future successful services.
C1 [Di Lorito, Claudio; Booth, Vicky; Howe, Louise] Univ Nottingham, Sch Med, Nottingham, England.
   [Bosco, Alessandro; Todd, Chris] Univ Manchester, Sch Hlth Sci, Manchester, Lancs, England.
   [Rai, Harleen] Univ Strathclyde, Comp & Informat Sci, Glasgow, Lanark, Scotland.
   [Craven, Michael] Inst Mental Hlth, Mindtech, Nottingham, England.
   [McNally, Donal] Univ Nottingham, Fac Engn, Nottingham, England.
   [Cowley, Alison] Nottingham Univ Hosp NHS Trust, Nottingham, England.
   [Harwood, Rowan H.] Univ Nottingham, Sch Hlth Sci, Nottingham, England.
C3 University of Nottingham; N8 Research Partnership; University of
   Manchester; University of Strathclyde; University of Nottingham;
   Nottingham University Hospital NHS Trust; University of Nottingham
RP Di Lorito, C (corresponding author), Queens Med Ctr, Room B109, Nottingham NG7 2TU, England.
EM Claudio.dilorito@nottingham.ac.uk
RI Todd, Chris/A-7904-2010; Craven, Michael P./B-5305-2012
OI Todd, Chris/0000-0001-6645-4505; Craven, Michael P./0000-0001-5682-6360;
   Cowley, Alison/0000-0001-6858-475X; Harwood, Rowan/0000-0002-4920-6718;
   Di Lorito, Claudio/0000-0002-8953-0117; Booth, Vicky/0000-0002-5338-0196
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NR 66
TC 4
Z9 4
U1 5
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD JUN
PY 2022
VL 37
IS 6
DI 10.1002/gps.5730
PG 25
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 2C8XN
UT WOS:000811144000001
PM 35588315
OA hybrid, Green Published, Green Accepted
DA 2023-08-17
ER

PT J
AU Bramley, T
AF Bramley, T.
TI The development of an occupational therapy component of a complex
   intervention for people with mild cognitive impairment (MCI) and
   dementia
SO BRITISH JOURNAL OF OCCUPATIONAL THERAPY
LA English
DT Meeting Abstract
DE Dementia; Occupational therapy; Older people
C1 [Bramley, T.] Nottingham Univ & Nottinghamshire Healthcare, Nottingham, England.
EM msatb5@exmail.nottingham.ac.uk
CR Craig P, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1655
   Fisher AG, 1998, AM J OCCUP THER, V52, P509, DOI 10.5014/ajot.52.7.509
NR 2
TC 0
Z9 0
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0308-0226
EI 1477-6006
J9 BRIT J OCCUP THER
JI Br. J. Occup. Ther.
PD AUG
PY 2017
VL 80
SU 8
MA Poster P44
BP 82
EP 82
PG 1
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA FC8AU
UT WOS:000407064700165
DA 2023-08-17
ER

PT J
AU Forster, S
   Buschert, VC
   Teipel, SJ
   Friese, U
   Buchholz, HG
   Drzezga, A
   Hampel, H
   Bartenstein, P
   Buerger, K
AF Foerster, Stefan
   Buschert, Verena C.
   Teipel, Stefan J.
   Friese, Uwe
   Buchholz, Hans-Georg
   Drzezga, Alexander
   Hampel, Harald
   Bartenstein, Peter
   Buerger, Katharina
TI Effects of a 6-Month Cognitive Intervention on Brain Metabolism in
   Patients with Amnestic MCI and Mild Alzheimer's Disease
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE FDG PET; cognitive intervention; cognitive training; cognitive
   stimulation; Alzheimer's disease; mild cognitive impairment
ID ANTERIOR CINGULATE CORTEX; GLOBAL MEAN NORMALIZATION; RATING-SCALE;
   FOLLOW-UP; FDG-PET; IMPAIRMENT; DEMENTIA; ACTIVATION; EFFICACY; RESERVE
AB The effect of cognitive intervention on brain metabolism in AD is largely unexplored. Therefore, we aimed to investigate cognitive parameters and (18)FDG PET to test for effects of a cognitive intervention in patients with aMCI or mild AD. Patients with aMCI (N = 24) or mild AD (N = 15) were randomly assigned either to cognitive intervention groups (IGs), receiving weekly sessions of group-based multicomponent cognitive intervention, or active control groups (CGs), receiving pencil-paper exercises for self-study. We obtained resting-state FDG-PET scans and neuropsychological testing at baseline and after six-months. Normalized FDG-PET images were analyzed using voxel-based SPM5 approaches to determine longitudinal changes, group-by-time interactions and correlations with neuropsychological outcome parameters. Primary global cognitive outcome was determined by analyses of covariance with MMSE and ADAS-cog scores as dependent measures. Both, aMCI and AD subgroups of CGs showed widespread bilateral cortical declines in FDG uptake, while the AD subgroup of IGs showed discrete decline or rather no decline in case of the aMCI subgroup. Group by time analyses revealed strongest attenuation of metabolic decline in the aMCI subgroup of the IGs, involving left anterior temporal pole and anterior cingulate gyrus. However, correlation analyses revealed only weak non-significant associations between increased FDG uptake and improvement in primary or secondary outcome parameters. Concurrently, there was significant improvement in global cognitive status in the aMCI subgroup of the IGs. A six-month cognitive intervention imparted cognitive benefits in patients with aMCI, which were concurrent with an attenuated decline of glucose metabolism in cortical regions affected by neurodegenerative AD.
C1 [Foerster, Stefan] Tech Univ Munich, Nukl Med Klin & Poliklin, Dept Nucl Med, D-81675 Munich, Germany.
   [Foerster, Stefan; Bartenstein, Peter] Univ Munich, Dept Nucl Med, Munich, Germany.
   [Buschert, Verena C.; Buerger, Katharina] Univ Munich, Dementia Res Sect, Munich, Germany.
   [Buschert, Verena C.; Buerger, Katharina] Univ Munich, Alzheimer Mem Ctr, Memory Clin, Munich, Germany.
   [Buschert, Verena C.; Buerger, Katharina] Univ Munich, Dept Psychiat, Geriatr Psychiat Branch, Munich, Germany.
   [Teipel, Stefan J.; Friese, Uwe] Univ Rostock, Dept Psychiat, Rostock, Germany.
   [Teipel, Stefan J.] German Ctr Neurodegenerat Disorders, DZNE, Rostock, Germany.
   [Hampel, Harald] Univ Dublin, Trinity Coll, Sch Med, Discipline Psychiat, Dublin, Ireland.
   [Hampel, Harald] Univ Dublin, Trinity Coll, Lab Neuroimaging & Biomarker Res, TCIN, Dublin, Ireland.
   [Buchholz, Hans-Georg] Johannes Gutenberg Univ Mainz, Dept Nucl Med, Mainz, Germany.
   [Friese, Uwe] Univ Osnabruck, Inst Psychol, Osnabruck, Germany.
   [Buerger, Katharina] Univ Munich, Klinikum Grosshadern, Inst Stroke & Dementia Res, D-8000 Munich, Germany.
C3 Technical University of Munich; University of Munich; University of
   Munich; University of Munich; University of Munich; University of
   Munich; University of Rostock; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE); Trinity College Dublin; Trinity
   College Dublin; Johannes Gutenberg University of Mainz; University
   Osnabruck; University of Munich
RP Forster, S (corresponding author), Tech Univ Munich, Nukl Med Klin & Poliklin, Dept Nucl Med, Ismaninger Str 22, D-81675 Munich, Germany.
EM stefan-foerster@gmx.de
RI Lista, Simone/AAC-6473-2021
OI Lista, Simone/0000-0001-6804-7858; Hampel, Harald/0000-0003-0894-8982;
   Drzezga, Alexander/0000-0001-6018-716X
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NR 40
TC 38
Z9 38
U1 0
U2 29
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2011
VL 26
SU 3
BP 337
EP 348
DI 10.3233/JAD-2011-0025
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 858ZM
UT WOS:000297842800026
PM 21971473
DA 2023-08-17
ER

PT J
AU Dieckelmann, M
   Gonzalez-Gonzalez, AI
   Banzer, W
   Berghold, A
   Jeitler, K
   Pantel, J
   Schall, A
   Tesky, VA
   Siebenhofer, A
AF Dieckelmann, Mirjam
   Gonzalez-Gonzalez, Ana Isabel
   Banzer, Winfried
   Berghold, Andrea
   Jeitler, Klaus
   Pantel, Johannes
   Schall, Arthur
   Tesky, Valentina A.
   Siebenhofer, Andrea
TI Effectiveness of exercise and physical activity interventions to improve
   long-term patient-relevant cognitive and non-cognitive outcomes in
   people living with mild cognitive impairment: a protocol of a systematic
   review and meta-analysis
SO BMJ OPEN
LA English
DT Review
DE dementia; preventive medicine; primary care; sports medicine
ID ALZHEIMERS ASSOCIATION WORKGROUPS; QUALITY-OF-LIFE; DIAGNOSTIC
   GUIDELINES; NATIONAL INSTITUTE; DEMENTIA; CONSENSUS; DISEASE;
   RECOMMENDATIONS; INVENTORY
AB Introduction Mild cognitive impairment (MCI) is a clinical syndrome characterised by persistent cognitive deficits that do not yet fulfil the criteria of dementia. Delaying the onset of dementia using secondary preventive measures such as physical activity and exercise can be a safe way of reducing the risk of further cognitive decline and maintaining independence and improving quality of life. The aim is to systematically review the literature to assess the effectiveness of physical activity and exercise interventions to improve long-term patient-relevant cognitive and non-cognitive outcomes in people living with MCI, including meta-analyses if applicable. Methods and analysis We will systematically search five electronic databases from 1995 onward to identify trials reporting on the effectiveness of physical activity and exercise interventions to improve long-term (12+ months) patient-relevant cognitive and non-cognitive outcomes in adults (50+ years) with MCI. Screening procedures, selection of eligible full-texts, data extraction and risk of bias assessment will be performed in dual-review mode. Additionally, the reporting quality of the exercise interventions will be assessed using the Consensus on Exercise Reporting Template. A quantitative synthesis will only be conducted if studies are homogeneous enough for effect sizes to be pooled. Where quantitative analysis is not applicable, data will be represented in a tabular form and synthesised narratively. People living with MCI will be involved in defining outcome measures most relevant to them in order to assess in how far randomised controlled trials report endpoints that matter to those concerned. Ethics and dissemination Results will be disseminated to both scientific and lay audiences by creating a patient-friendly video abstract. This work will inform professionals in primary care about the effectiveness of physical activity and exercise interventions and support them to make evidence-based exercise recommendations for the secondary prevention of dementia in people living with MCI. No ethical approval required. PROSPERO registration number CRD42021287166.
C1 [Dieckelmann, Mirjam; Gonzalez-Gonzalez, Ana Isabel; Pantel, Johannes; Schall, Arthur; Tesky, Valentina A.; Siebenhofer, Andrea] Goethe Univ Frankfurt Main, Inst Gen Practice, Frankfurt, Germany.
   [Gonzalez-Gonzalez, Ana Isabel] Red Invest Cronicidad, Atenc Primaria & Promot Salud RICAPPS, Madrid, Spain.
   [Banzer, Winfried] Goethe Univ, Inst Occupat Social & Environm Med, Frankfurt, Germany.
   [Berghold, Andrea; Jeitler, Klaus] Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria.
   [Jeitler, Klaus; Siebenhofer, Andrea] Med Univ Graz, Inst Gen Practice & Evidence Based Hlth Serv Res, Graz, Austria.
C3 Goethe University Frankfurt; Goethe University Frankfurt; Medical
   University of Graz; Medical University of Graz
RP Siebenhofer, A (corresponding author), Goethe Univ Frankfurt Main, Inst Gen Practice, Frankfurt, Germany.; Siebenhofer, A (corresponding author), Med Univ Graz, Inst Gen Practice & Evidence Based Hlth Serv Res, Graz, Austria.
EM andrea.siebenhofer@medunigraz.at
OI Dieckelmann, Mirjam/0000-0002-5243-7840; Berghold,
   Andrea/0000-0001-5187-9105
FU German Federal Ministry of Education and Research [01KG2103]
FX This work is supported by the German Federal Ministry of Education and
   Research, grant number 01KG2103. The funder was not involved in
   developing the protocol.
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NR 41
TC 0
Z9 0
U1 1
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD AUG
PY 2022
VL 12
IS 8
AR e063396
DI 10.1136/bmjopen-2022-063396
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4C9LY
UT WOS:000846766300009
PM 35998967
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Pisot, R
   Paravlic, A
   Marusic, U
   Simunic, B
AF Pisot, Rado
   Paravlic, Armin
   Marusic, Uros
   Simunic, Bostjan
TI Physical Activity Intervention In Older Adults: Greater Gains In
   Functional Performance In Older Adults At Higher Risk For Mild Cognitive
   Impairment
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
CT Annual Meeting of the American-College-of-Sports-Medicine (ACSM)
CY MAY 30-JUN 03, 2017
CL Denver, CO
SP Amer Coll Sports Med
C1 [Pisot, Rado; Paravlic, Armin; Marusic, Uros; Simunic, Bostjan] Univ Primorska, Koper, Slovenia.
C3 University of Primorska
EM rado.pisot@zrs.upr.si
RI Paravlic, Armin/AFH-5347-2022
OI Paravlic, Armin/0000-0002-7748-8097; Marusic, Uros/0000-0002-7420-2137
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2017
VL 49
IS 5
SU 1
MA 1276
BP 345
EP 345
DI 10.1249/01.mss.0000517820.25334.99
PG 1
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Sport Sciences
GA FM6ZK
UT WOS:000415214600227
DA 2023-08-17
ER

PT J
AU Farrand, P
   Matthews, J
   Dickens, C
   Anderson, M
   Woodford, J
AF Farrand, Paul
   Matthews, Justin
   Dickens, Chris
   Anderson, Martin
   Woodford, Joanne
TI Psychological interventions to improve psychological well-being in
   people with dementia or mild cognitive impairment: systematic review and
   meta-analysis protocol
SO BMJ OPEN
LA English
DT Review
ID PHYSICAL HEALTH CONDITIONS; RANDOM-EFFECTS MODELS; BEHAVIORAL SELF-HELP;
   QUALITY-OF-LIFE; OLDER-ADULTS; NEUROPSYCHIATRIC SYMPTOMS; DEPRESSIVE
   SYMPTOMS; DIAGNOSTIC-CRITERIA; CONTROLLED-TRIALS; PUBLICATION BIAS
AB Introduction: Dementia and mild cognitive impairment are associated with an increased risk of depression, anxiety, psychological distress and poor mental health-related quality of life. However, there is a lack of research examining the evidence base for psychological interventions targeting general psychological well-being within this population. Furthermore, there is little research relating to the design of randomised controlled trials examining psychological interventions for dementia and mild cognitive impairment, such as effective recruitment techniques, trial eligibility and appropriate comparators.
   Methods and analysis: Systematic review of electronic databases (CINAHL; EMBASE; PsychInfo; MEDLINE; ASSIA and CENTRAL), supplemented by expert contact, reference and citation checking, and grey literature searches. Published and unpublished studies will be eligible for inclusion with no limitations placed on year of publication. Primary outcomes of interest will be standardised measurements of depression, anxiety, psychological distress or mental health-related quality of life. Eligibility and randomisation proportions will be calculated as secondary outcomes. If data permits, meta-analytical techniques will examine: (1) overall effectiveness of psychological interventions for people with dementia or mild cognitive impairment in relation to outcomes of depression, anxiety, psychological distress or mental health-related quality of life; (2) clinical and methodological moderators associated with effectiveness; (3) proportions eligible, recruited and randomised.
   Ethics and dissemination: Ethical approval is not required for the present systematic review. Results will inform the design of a feasibility study examining a new psychological intervention for people with dementia and depression, with dissemination through publication in peer-reviewed journals and presentations at relevant conferences.
C1 [Farrand, Paul; Anderson, Martin; Woodford, Joanne] Univ Exeter, Psychol Coll Life & Environm Sci, Clin Educ Dev & Res CEDAR Grp, Exeter, Devon, England.
   [Farrand, Paul; Dickens, Chris] Univ Exeter, Sch Med, Mental Hlth Res Grp, Exeter, Devon, England.
   [Matthews, Justin] Univ Exeter, Sch Med, Hlth Stat Grp, NIHR PenCLAHRC, Exeter, Devon, England.
C3 University of Exeter; University of Exeter; University of Exeter
RP Farrand, P (corresponding author), Univ Exeter, Psychol Coll Life & Environm Sci, Clin Educ Dev & Res CEDAR Grp, Exeter, Devon, England.
EM p.a.farrand@exeter.ac.uk
RI Matthews, Justin/AAM-8972-2020; Woodford, Joanne/J-4056-2015
OI Matthews, Justin/0000-0002-3743-1627; Woodford,
   Joanne/0000-0001-5062-6798; Dickens, Chris/0000-0001-6326-7544
FU Cornwall Partnership NHS Foundation Trust (CFT); South West Peninsula
   Academic Health Sciences Network (SWAHSN); University of Exeter;
   National Institute for Health Research (NIHR) Collaboration for
   Leadership in Applied Health Research and Care South West Peninsula
FX This paper is supported by funding provided by Cornwall Partnership NHS
   Foundation Trust (CFT), South West Peninsula Academic Health Sciences
   Network (SWAHSN), and the University of Exeter. JM was supported by the
   National Institute for Health Research (NIHR) Collaboration for
   Leadership in Applied Health Research and Care South West Peninsula.
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NR 81
TC 9
Z9 9
U1 1
U2 18
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2016
VL 6
IS 1
AR e009713
DI 10.1136/bmjopen-2015-009713
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA DD5VX
UT WOS:000369993900122
PM 26817638
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU D'Cunha, NM
   Nguyen, D
   Naumovski, N
   McKune, AJ
   Kellett, J
   Georgousopoulou, EN
   Frost, J
   Isbel, S
AF D'Cunha, Nathan M.
   Dung Nguyen
   Naumovski, Nenad
   McKune, Andrew J.
   Kellett, Jane
   Georgousopoulou, Ekavi N.
   Frost, Jane
   Isbel, Stephen
TI A Mini-Review of Virtual Reality-Based Interventions to Promote
   Well-Being for People Living with Dementia and Mild Cognitive Impairment
SO GERONTOLOGY
LA English
DT Review
DE Virtual reality; Dementia; Mild cognitive impairment; Alzheimer's
   disease; Feasibility studies
ID MEMORY TRAINING-PROGRAM; OLDER-ADULTS; FEASIBILITY; TECHNOLOGY;
   ATTITUDES; EXERCISE
AB Assistive technology including virtual reality and augmented reality has gained interest as a novel intervention in a range of clinical settings. This technology has the potential to provide mental stimulation, a connection to autobiographical memory through reminiscence, and enhanced quality of life (QoL) to people living with dementia (PLWD) and mild cognitive impairment (MCI). In this mini-review, we examine the available evidence from studies reporting on the potential benefits of virtual and augmented reality to provide enjoyable, leisurely activities that may promote QoL and psychological well-being and facilitate social interaction. In total, 10 studies of varying study designs and durations (5 min to 6 months) using virtual (n = 9) and augmented reality (n = 1) were examined in PLWD (n = 6) and MCI (n= 3), in addition to 1 study that included participants with both conditions. Overall, the virtual experiences were enjoyed by the participants, improved their mood and apathy, and were preferred when compared with nonvirtual experiences. However, small sample sizes and variations in study design limit the generalizability of the results. Nevertheless, the use of virtual and augmented reality technology for PLWD and MCI is a novel and emerging method which may provide cognitive stimulation and improve well-being. Future research should explore the potential application of this technology to promote social interaction in both the community and aged care settings. We suggest future studies in PLWD and MCI assess the effects of more sustained use of virtual and augmented reality technology on psychological outcomes including QoL, apathy, and depressive symptoms, with the incorporation of physiological biomarker outcomes.
C1 [D'Cunha, Nathan M.; Dung Nguyen; Naumovski, Nenad; McKune, Andrew J.; Kellett, Jane; Frost, Jane; Isbel, Stephen] Univ Canberra, Fac Hlth, Canberra, ACT, Australia.
   [D'Cunha, Nathan M.; Naumovski, Nenad; McKune, Andrew J.; Kellett, Jane; Georgousopoulou, Ekavi N.; Isbel, Stephen] Univ Canberra, Collaborat Res Bioact & Biomarkers CRIBB Grp, Canberra, ACT, Australia.
   [McKune, Andrew J.] Univ Canberra, Res Inst Sport & Exercise, Fac Hlth, Discipline Sport & Exercise Sci, Canberra, ACT, Australia.
   [McKune, Andrew J.] Univ KwaZulu Natal, Sch Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, Durban, South Africa.
   [Georgousopoulou, Ekavi N.] Australian Natl Univ, Med Sch, Canberra, ACT, Australia.
   [Georgousopoulou, Ekavi N.] Univ Notre Dame, Sch Med, Sydney, NSW, Australia.
C3 University of Canberra; University of Canberra; University of Canberra;
   University of Kwazulu Natal; Australian National University; University
   of Notre Dame Australia
RP D'Cunha, NM (corresponding author), Univ Canberra, Fac Hlth, Univ Canberra Hosp, 20 Guraguma St, Bruce, ACT 2617, Australia.
EM nathan.dcunha@canberra.edu.au
RI Georgousopoulou, Ekavi/AAC-2563-2019; McKune, Andrew/AAM-3086-2020;
   D'Cunha, Nathan M/P-5518-2017; Naumovski, Nenad/O-5617-2015
OI McKune, Andrew/0000-0002-5479-1544; D'Cunha, Nathan
   M/0000-0002-4616-9931; Naumovski, Nenad/0000-0002-2841-4497; Frost,
   Jane/0000-0002-2717-4727; Kellett, Jane/0000-0003-0586-3203
FU Dementia Australia Research Foundation PhD scholarship
FX Nathan M. D'Cunha is supported by a Dementia Australia Research
   Foundation PhD scholarship.
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NR 43
TC 76
Z9 79
U1 12
U2 78
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0304-324X
EI 1423-0003
J9 GERONTOLOGY
JI Gerontology
PY 2019
VL 65
IS 4
BP 430
EP 440
DI 10.1159/000500040
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA II6LV
UT WOS:000475306300013
PM 31108489
OA Bronze
DA 2023-08-17
ER

PT J
AU Tonga, JB
   Benth, JS
   Arnevik, EA
   Werheid, K
   Korsnes, MS
   Ulstein, ID
AF Tonga, Johanne B.
   Benth, Jurate Saltyte
   Arnevik, Espen A.
   Werheid, Katja
   Korsnes, Maria S.
   Ulstein, Ingun D.
TI Managing depressive symptoms in people with mild cognitive impairment
   and mild dementia with a multicomponent psychotherapy intervention: a
   randomized controlled trial
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE dementia; mild cognitive impairment; cognitive rehabilitation; cognitive
   behavioral therapy; reminiscence therapy; psychosocial intervention;
   depressive symptoms; MADRS
ID ALZHEIMERS-DISEASE; REMINISCENCE THERAPY; PSYCHOSOCIAL INTERVENTIONS;
   INSTRUMENTAL ACTIVITIES; DETECTING DEPRESSION; HOSPITAL ANXIETY; SCALE;
   REHABILITATION; VALIDITY; METAANALYSIS
AB Objective:
   To evaluate the feasibility and effectiveness of the CORDIAL program, a psychosocial intervention consisting of cognitive behavioral therapy (CBT), cognitive rehabilitation, and reminiscence to manage depressive symptoms for people with mild cognitive impairment (MCI) or dementia.
   Design:
   We conducted a randomized controlled trial, based on a two-group (intervention and control), pre-/post-intervention design.
   Setting:
   Participants were recruited from five different old age psychiatry and memory clinics at outpatients' hospitals.
   Participants:
   Hundred and ninety-eight people with MCI or early-stage dementia were included.
   Intervention:
   The intervention group (n = 100) received 11 individual weekly sessions of the CORDIAL program. This intervention includes elements from CBT, cognitive rehabilitation, and reminiscence therapy. The control group (n = 98) received treatment-as-usual.
   Measurements:
   We assessed Montgomery-angstrom sberg Depression Rating Scale (MADRS) (main outcome), Neuropsychiatric Inventory Questionnaire, and Quality of Life in Alzheimer's disease (secondary outcomes) over the course of 4 months and at a 10-month follow-up visit.
   Results:
   A linear mixed model demonstrated that the depressive symptoms assessed by MADRS were significantly more reduced in the intervention groups as compared to the control group (p < 0.001). The effect persisted for 6 months after the intervention. No significant differences between groups were found in neuropsychiatric symptoms or quality of life.
   Conclusion:
   Our multicomponent intervention, which comprised 11 individual sessions of CBT, cognitive rehabilitation, and reminiscence therapy, reduced depressive symptoms in people with MCI and dementia.
C1 [Tonga, Johanne B.; Korsnes, Maria S.] Oslo Univ Hosp, Dept Old Age Psychiat, Postbox 4956, N-0424 Oslo, Norway.
   [Tonga, Johanne B.] Norwegian Hlth Assoc, Postbox 7139 Majorstuen, N-0207 Oslo, Norway.
   [Tonga, Johanne B.] Univ Oslo, Inst Psychol, Postbox 1094, N-0317 Oslo, Norway.
   [Benth, Jurate Saltyte] Univ Oslo, Inst Clin Med, Campus Ahus,POB 1171, N-0318 Blindern, Norway.
   [Benth, Jurate Saltyte] Akershus Univ Hosp, Hlth Serv Res Unit, Postbox 1000, N-1000 Lorenskog, Norway.
   [Arnevik, Espen A.] Oslo Univ Hosp, Div Mental Hlth & Addict, Postbox 4956, N-0424 Oslo, Norway.
   [Werheid, Katja] Humboldt Univ, Dept Psychol, Clin Neuropsychol, Rudower Chaussee 18, D-12489 Berlin, Germany.
   [Ulstein, Ingun D.] Oslo Univ Hosp, Dept Geriatr Med, Postbox 4956, N-0424 Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; University
   of Oslo; University of Oslo; Humboldt University of Berlin; University
   of Oslo
RP Tonga, JB (corresponding author), Oslo Univ Hosp, Dept Old Age Psychiat, Postbox 4956, N-0424 Oslo, Norway.
EM jotbjo@ous-hf.no
RI Benth, Jurate Saltyte/A-5046-2008
OI Saltyte Benth, Jurate/0000-0003-4199-2272
FU Norwegian Health Association; Old Age Psychiatry Research Network;
   Telemark Hospital Trust; Vestfold Trust (TeVe); Department of Old Age
   Psychiatry; Oslo University Hospital; Civitan Norway Research Foundation
   of Alzheimer's Disease
FX The CORDIAL study was funded by the Norwegian Health Association, the
   Old Age Psychiatry Research Network, Telemark Hospital Trust and
   Vestfold Trust (TeVe), the Department of Old Age Psychiatry, Oslo
   University Hospital, and the Civitan Norway Research Foundation of
   Alzheimer's Disease. The authors did not enter into an agreement with a
   funding organization. The research team would like to thank all the
   participants and caregivers that participated in this study, and the
   health staff that helped with the study. Thanks to A.I. Thone-Otto, who
   conjointly developed the CORDIAL program with K. Werheid. We would also
   like to thank the following hospitals for participating: Department of
   Geriatric Medicine, Institute of Clinical Medicine, Oslo University
   Hospital, Ulleval, Norway; Department of Old Age Psychiatry, Oslo
   University Hospital, Gronland, Norway; Department of Old Age Psychiatry,
   Akershus University Hospital, Skytta, Norway; Department of Old Age
   Psychiatry, Innlandet Hospital Trust, Sanderud, Norway; and Department
   of Old Age Psychiatry, Vestfold Hospital Trust, Granli, Norway.
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NR 65
TC 16
Z9 17
U1 3
U2 29
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD MAR
PY 2021
VL 33
IS 3
SI SI
BP 217
EP 231
AR PII S1041610220000216
DI 10.1017/S1041610220000216
PG 15
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA RF0KP
UT WOS:000634537500007
PM 32131911
OA Green Published, hybrid
DA 2023-08-17
ER

PT J
AU Thapa, N
   Park, HJ
   Yang, JG
   Son, H
   Jang, M
   Lee, J
   Kang, SW
   Park, KW
   Park, H
AF Thapa, Ngeemasara
   Park, Hye Jin
   Yang, Ja-Gyeong
   Son, Haeun
   Jang, Minwoo
   Lee, Jihyeon
   Kang, Seung Wan
   Park, Kyung Won
   Park, Hyuntae
TI The Effect of a Virtual Reality-Based Intervention Program on Cognition
   in Older Adults with Mild Cognitive Impairment: A Randomized Control
   Trial
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE virtual reality; dementia; mild cognitive impairment;
   electroencephalogram
ID DEMENTIA; DECLINE; MEMORY; INDIVIDUALS; VALIDITY; DISEASE; TRAIL; SPEED
AB This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group-time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline.
C1 [Thapa, Ngeemasara; Park, Hye Jin; Yang, Ja-Gyeong; Son, Haeun; Jang, Minwoo; Lee, Jihyeon; Park, Hyuntae] Dong A Univ, Grad Sch, Dept Hlth Sci, Busan 49315, South Korea.
   [Thapa, Ngeemasara; Park, Hye Jin; Yang, Ja-Gyeong; Son, Haeun; Jang, Minwoo; Park, Hyuntae] Dong A Univ, Lab Smart Healthcare, Busan 49315, South Korea.
   [Kang, Seung Wan] Seoul Natl Univ, Coll Nursing, Data Ctr Korean EEG, Seoul 03080, South Korea.
   [Park, Kyung Won] Dong A Univ, Dept Neurol, Coll Med, Busan 49201, South Korea.
C3 Dong A University; Dong A University; Seoul National University (SNU);
   Dong A University
RP Park, H (corresponding author), Dong A Univ, Grad Sch, Dept Hlth Sci, Busan 49315, South Korea.; Park, H (corresponding author), Dong A Univ, Lab Smart Healthcare, Busan 49315, South Korea.
EM ngeemasara@gmail.com; mihd3987@hanmail.net; sky940702@naver.com;
   haundl123@naver.com; mtow0620@gmail.com; lose0918@naver.com;
   drdemian@snu.ac.kr; neuropark@dau.ac.kr; htpark@dau.ac.kr
RI Park, Hyuntae/AAE-4672-2019
OI Park, Hyuntae/0000-0002-1976-0005; Thapa,
   Ngeemasara/0000-0001-9394-2539; Park, Kyung Won/0000-0002-6788-5267
FU Dong-A University research grant
FX This research was funded by the Dong-A University research grant.
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NR 50
TC 65
Z9 67
U1 15
U2 55
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2020
VL 9
IS 5
AR 1283
DI 10.3390/jcm9051283
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LY0OO
UT WOS:000540223800040
PM 32365533
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Hammink, JHW
   Moor, JA
   Mohammadi, M
AF Hammink, J. H. W. (Coosje)
   Moor, J. A. (Nienke)
   Mohammadi, M. (Masi)
TI Influencing health behaviour using smart building interventions for
   people with dementia and mild cognitive impairment: expert interviews
   and a systematic literature review
SO DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
LA English
DT Review; Early Access
DE Smart building intervention; dementia; behaviour change mechanisms;
   social cognitive theory; systematic literature review; expert interviews
ID NURSING-HOME RESIDENTS; PHYSICAL-ACTIVITY; SELF-EFFICACY; ASSISTIVE
   TECHNOLOGY; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; CARE; SUPPORT;
   REMEDIATION; PREVENTION
AB Purpose Behaviour can have an influence on (coping with) chronic conditions such as dementia. Assistive technology can stimulate the daily behaviour of people with dementia, but the mechanisms through which this happens are unclear. Therefore, this paper focuses on potential behaviour change mechanisms, that can be employed in smart building interventions for people with dementia or MCI. Methods This research uses expert interviews with medical experts (n = 9) and a systematic literature review of smart building interventions stimulating health behaviour (n = 12). Results Results show how facilitation, incentive motivation (i.e., feedback), observational learning and self-efficacy are most promising according to medical experts; if they are appropriately personalised towards needs, preferences as well as abilities. The literature review shows how most of the examined research uses facilitation and incentive motivation to stimulate behaviour. Although positive results are reported in all studies, methodological quality could be improved. Conclusion For the design of smart building interventions for people with MCI or dementia, facilitation and incentive motivation seem to be promising behaviour change mechanisms. Outcome expectation, observational learning and self-efficacy could reinforcing the aforementioned mechanisms. Future research should focus on how different (environmental, digital) cues can be personalized and can adapt over time, as dementia progresses.
C1 [Hammink, J. H. W. (Coosje); Moor, J. A. (Nienke); Mohammadi, M. (Masi)] HAN Univ Appl Sci, Res Grp Architecture Hlth, Ruitenberglaan 26, NL-6826 CC Arnhem, Netherlands.
   [Mohammadi, M. (Masi)] Eindhoven Univ Technol, Smart Architectural Technol, Eindhoven, Netherlands.
C3 Eindhoven University of Technology
RP Hammink, JHW (corresponding author), HAN Univ Appl Sci, Res Grp Architecture Hlth, Ruitenberglaan 26, NL-6826 CC Arnhem, Netherlands.
EM coosje.hammink@han.nl
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NR 78
TC 0
Z9 0
U1 1
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1748-3107
EI 1748-3115
J9 DISABIL REHABIL-ASSI
JI Disabil. Rehabil.-Assist. Technol.
PD 2021 NOV 2
PY 2021
DI 10.1080/17483107.2021.1994032
EA NOV 2021
PG 17
WC Rehabilitation
WE Social Science Citation Index (SSCI)
SC Rehabilitation
GA WR1IU
UT WOS:000714261500001
PM 34731590
DA 2023-08-17
ER

PT J
AU Regan, B
   Wells, Y
   O'Halloran, P
AF Regan, Bridget
   Wells, Yvonne
   O'Halloran, Paul
TI "I'm more aware now": perspectives from people with mild cognitive
   impairment (MCI), supporters and counsellors about the MAXCOG cognitive
   rehabilitation intervention
SO AGING & MENTAL HEALTH
LA English
DT Article
DE Mild cognitive impairment; cognitive rehabilitation; thematic analysis
ID MAXIMIZING COGNITION
AB Objectives: Cognitive Rehabilitation interventions have the potential to improve quality of life for people with MCI. We recently developed, trialled, and evaluated the use of the MAXCOG (Maximising Cognition) intervention-a very brief (four-session) face-to-face program focussing on individualised goals to improve function in daily life. Although the program assisted people reach their practical goals, we could not demonstrate broader changes to quality of life, mood, or carer burden. The aim of this study was to explore qualitatively the experiences of clients, supporters, and counsellors who participated. Method: Fifteen clients, fourteen supporters, and three counsellors were interviewed using the Most Significant Change technique. Subsequently, thirty-five narrative accounts were transcribed and subjected to thematic analysis following Braun and Clarke's (2006) model. Results: Key themes identified changes at two levels: specific changes (Putting strategies in place; and Doing it differently) and meta changes (More aware now; Facing up to life; and on top of anxiety and stress). Participants also mentioned supports and hindrances. Conclusion: The analysis provided a new perspective on the experiences of participants, supporters, and counsellors with the MAXCOG intervention, including identification of psychological changes that were not apparent from the quantitative analyses.
C1 [Regan, Bridget; Wells, Yvonne] La Trobe Univ, Lincoln Ctr Res Ageing, Australian Inst Primary Care & Ageing, Melbourne, Vic, Australia.
   [O'Halloran, Paul] La Trobe Univ, Sch Psychol & Publ Hlth, Melbourne, Vic, Australia.
C3 La Trobe University; La Trobe University
RP Regan, B (corresponding author), La Trobe Univ, Lincoln Ctr Res Ageing, Australian Inst Primary Care & Ageing, Melbourne, Vic, Australia.
EM 18348146@students.latrobe.edu.au
RI Wells, Yvonne/J-4597-2015
OI Wells, Yvonne/0000-0002-9678-5580
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NR 15
TC 1
Z9 1
U1 0
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD JUN 2
PY 2020
VL 24
IS 6
BP 965
EP 970
DI 10.1080/13607863.2019.1574712
PG 6
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA LS9RR
UT WOS:000536716600014
PM 30739472
DA 2023-08-17
ER

PT J
AU Bakker, A
   Albert, MS
   Krauss, G
   Speck, CL
   Gallagher, M
AF Bakker, Arnold
   Albert, Marilyn S.
   Krauss, Gregory
   Speck, Caroline L.
   Gallagher, Michela
TI Response of the medial temporal lobe network in amnestic mild cognitive
   impairment to therapeutic intervention assessed by fMRI and memory task
   performance
SO NEUROIMAGE-CLINICAL
LA English
DT Article
DE Mild cognitive impairment; Levetiracetam; Memory; fMRI; Dentate gyrus;
   Entorhinal cortex
ID COMPLEMENTARY-LEARNING-SYSTEMS; HIGH-RESOLUTION FMRI; PATTERN
   SEPARATION; ALZHEIMERS-DISEASE; AGED RATS; PLACE CELLS; HIPPOCAMPAL
   ACTIVATION; ENTORHINAL CORTEX; TRANSGENIC MICE; DENTATE GYRUS
AB Studies of individuals with amnestic mild cognitive impairment (aMCI) have detected hyperactivity in the hippocampus during task-related functional magnetic resonance imaging (fMRI). Such elevated activation has been localized to the hippocampal dentate gyrus/CA3 (DG/CA3) during performance of a task designed to detect the computational contributions of those hippocampal circuits to episodic memory. The current investigation was conducted to test the hypothesis that greater hippocampal activation in aMCI represents a dysfunctional shift in the normal computational balance of the DG/CA3 regions, augmenting CA3-driven pattern completion at the expense of pattern separationmediated by the dentate gyrus. We tested this hypothesis using an intervention based on animal research demonstrating a beneficial effect on cognition by reducing excess hippocampal neural activity with low doses of the atypical anti-epileptic levetiracetam. In a within-subject design we assessed the effects of levetiracetam in three cohorts of aMCI participants, each receiving a different dose of levetiracetam. Elevated activation in the DG/CA3 region, together with impaired task performance, was detected in each aMCI cohort relative to an aged control group. We observed significant improvement in memory task performance under drug treatment relative to placebo in the aMCI cohorts at the 62.5 and 125 mg BID doses of levetiracetam. Drug treatment in those cohorts increased accuracy dependent on pattern separation processes and reduced errors attributable to an over-riding effect of pattern completion while normalizing fMRI activation in the DG/CA3 and entorhinal cortex. Similar to findings in animal studies, higher dosing at 250 mg BID had no significant benefit on either task performance or fMRI activation. Consistent with predictions based on the computational functions of the DG/CA3 elucidated in basic animal research, these data support a dysfunctional encoding mechanism detected by fMRI in individuals with aMCI and therapeutic intervention using fMRI to detect target engagement in response to treatment. (C) 2015 The Authors. Published by Elsevier Inc.
C1 [Bakker, Arnold; Speck, Caroline L.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 600 N Wolfe St Phipps 300, Baltimore, MD 21287 USA.
   [Albert, Marilyn S.; Krauss, Gregory] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA.
   [Gallagher, Michela] Johns Hopkins Sch Arts & Sci, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   University
RP Bakker, A (corresponding author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 600 N Wolfe St Phipps 300, Baltimore, MD 21287 USA.
EM abakker@jhu.edu
RI Bakker, Arnold B./F-8494-2010
OI Bakker, Arnold B./0000-0003-1489-1847; Gallagher,
   Michela/0000-0002-9585-6500
FU NIH [RC2AG036419]
FX We would like to thank Dr. Jason Brandt and Dr. Paul Dash for their help
   with participant recruitment. We would like to thank the staff of the
   F.M. Kirby Center for Functional Brain Imaging for their assistance with
   data collection. This work was supported by the NIH grant RC2AG036419 to
   M.G.
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NR 55
TC 183
Z9 192
U1 3
U2 20
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-1582
J9 NEUROIMAGE-CLIN
JI NeuroImage-Clin.
PY 2015
VL 7
BP 688
EP 698
DI 10.1016/j.nicl.2015.02.009
PG 11
WC Neuroimaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DI0GE
UT WOS:000373172600074
PM 25844322
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Hanson, AJ
   Banks, WA
   Bettcher, LF
   Pepin, R
   Raftery, D
   Navarro, SL
   Craft, S
AF Hanson, Angela J.
   Banks, William A.
   Bettcher, Lisa F.
   Pepin, Robert
   Raftery, Daniel
   Navarro, Sandi L.
   Craft, Suzanne
TI Cerebrospinal Fluid Metabolomics: Pilot Study of Using Metabolomics to
   Assess Diet and Metabolic Interventions in Alzheimer's Disease and Mild
   Cognitive Impairment
SO METABOLITES
LA English
DT Article
DE metabolomics; ketone bodies; cerebrospinal fluid; Alzheimer's; blood
   brain barrier
ID BETA-HYDROXYBUTYRATE; INSULIN-RESISTANCE; ENERGY-METABOLISM; OXIDATIVE
   STRESS; APOLIPOPROTEIN-E; HIGH-FAT; BRAIN; PLASMA; MODEL; BREAKFAST
AB Brain glucose hypometabolism is an early sign of Alzheimer's disease (AD), and interventions which offset this deficit, such as ketogenic diets, show promise as AD therapeutics. Conversely, high-fat feeding may exacerbate AD risk. We analyzed the metabolomic profile of cerebrospinal fluid (CSF) in a pilot study of older adults who underwent saline and triglyceride (TG) infusions. Older adults (12 cognitively normal (CN), age 65.3 +/- 8.1, and 9 with cognitive impairment (CI), age 70.9 +/- 8.6) underwent a 5 h TG or saline infusion on different days using a random crossover design; CSF was collected at the end of infusion. Aqueous metabolites were measured using a targeted mass spectroscopy (MS) platform focusing on 215 metabolites from over 35 different metabolic pathways. Data were analyzed using MetaboAnalyst 4.0 and SAS. Of the 215 targeted metabolites, 99 were detectable in CSF. Only one metabolite significantly differed by treatment: the ketone body 3-hydroxybutyrate (HBA). Post hoc analyses showed that HBA levels were associated with age and markers of metabolic syndrome and demonstrated different correlation patterns for the two treatments. When analyzed by cognitive diagnosis group, TG-induced increases in HBA were over 3 times higher for those with cognitive impairment (change score CN +9.8 uM +/- 8.3, CI +32.4 +/- 7.4, p = 0.0191). Interestingly, individuals with cognitive impairment had higher HBA levels after TG infusion than those with normal cognition. These results suggest that interventions that increase plasma ketones may lead to higher brain ketones in groups at risk for AD and should be confirmed in larger intervention studies.
C1 [Hanson, Angela J.; Banks, William A.] Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98104 USA.
   [Banks, William A.] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA 98102 USA.
   [Bettcher, Lisa F.; Pepin, Robert; Raftery, Daniel] Univ Washington, Northwest Metabol Res Ctr, Dept Anesthesiol & Pain Med, Seattle, WA 98109 USA.
   [Navarro, Sandi L.] Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
   [Craft, Suzanne] Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC 27109 USA.
C3 University of Washington; University of Washington Seattle; Geriatric
   Research Education & Clinical Center; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Vet Affairs Puget Sound Health
   Care System; University of Washington; University of Washington Seattle;
   Fred Hutchinson Cancer Center; Wake Forest University
RP Hanson, AJ (corresponding author), Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98104 USA.
EM hansonaj@uw.edu
OI Raftery, Daniel/0000-0003-2467-8118; Navarro, Sandi/0000-0002-4260-2486
FU National Institutes of Health [K23AG047978, P30DK035816, S10OD021562];
   Veterans Affairs Medical Center; Chair of Medicine Scholars Award from
   the University of Washington School of Medicine.
FX This study was funded by K23AG047978, P30DK035816, and S10OD021562 from
   the National Institutes of Health, the Veterans Affairs Medical Center,
   and the Chair of Medicine Scholars Award from the University of
   Washington School of Medicine.
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2023
VL 13
IS 4
AR 569
DI 10.3390/metabo13040569
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA E9UW0
UT WOS:000978915200001
PM 37110227
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Young, KW
   Ng, P
   Kwok, T
   Cheng, D
AF Young, Kim-wan
   Ng, Petrus
   Kwok, Timothy
   Cheng, Daphne
TI The effects of holistic health group interventions on improving the
   cognitive ability of persons with mild cognitive impairment: a
   randomized controlled trial
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE mild cognitive impairment; cognitive training; cognitive ability;
   short-term memory; Montreal Cognitive Assessment; holistic health group
ID OLDER-ADULTS; NONPHARMACOLOGICAL INTERVENTIONS; ALZHEIMERS-DISEASE;
   PEOPLE; TOOL
AB Purpose: Persons with mild cognitive impairment (PwMCI) are at a higher risk of developing dementia than those without cognitive impairment. This research study aims to evaluate the effectiveness of a holistic health group intervention, which is based on the holistic brain health approach as well as an Eastern approach to health care, on improving the cognitive ability of Chinese PwMCI.
   Research methods: In a randomized controlled trial (RCT), 38 Chinese PwMCI were randomly assigned to either a 10-session holistic health intervention group or the control group. The holistic health treatment group attempted to promote the acceptance of their illness, enhance memory and coping skills, develop a positive lifestyle, maintain positive emotions, and facilitate emotional support among participants. The 10-session holistic health group intervention was structured, with each session conducted once per week and similar to 90 minutes in length. Control group patients and their family caregivers received standardized basic educational materials that provided basic information on cognitive decline for them to read at home. The Montreal Cognitive Assessment (MoCA) test was used to assess the cognitive ability of PwMCI in the pre- and posttreatment periods by a research assistant who was blind to the group assignment of the participants.
   Results: The paired-samples t-test indicated that the treatment group (n=18) showed significant improvement in the MoCA score, whereas the control group (n=20) did not. Moreover, 2x2 (group x time) repeated-measures analysis of covariance (ANCOVA) demonstrated that the holistic health group treatment was significantly more effective than the control intervention in improving the MoCA score, with a moderate effect size, and improving the delayed recall (ie, short-term memory), with a strong effect size, after controlling for age, sex, education, and marital status.
   Conclusion: This present RCT provides evidence to support the feasibility and effectiveness of the holistic health group intervention in improving the cognitive and short-term memory abilities of PwMCI.
C1 [Young, Kim-wan; Ng, Petrus; Cheng, Daphne] Hong Kong Baptist Univ, Dept Social Work, AAB1025, Kowloon Tong, Hong Kong, Peoples R China.
   [Kwok, Timothy] Chinese Univ Hong Kong, Dept Med, Geriatr Div, Hong Kong, Hong Kong, Peoples R China.
C3 Hong Kong Baptist University; Chinese University of Hong Kong
RP Young, KW (corresponding author), Hong Kong Baptist Univ, Dept Social Work, AAB1025, Kowloon Tong, Hong Kong, Peoples R China.
EM danielyoung@hkbu.edu.hk
RI Young, Daniel/HKW-1747-2023; Kwok, Timothy/C-3725-2008
OI Kwok, Timothy/0000-0001-9253-3549; YOUNG, Kim Wan/0000-0002-6136-7389
FU Faculty of Social Sciences, Hong Kong Baptist University
   [FRG1/14-15/050]
FX This research work was financially supported by the Faculty of Social
   Sciences, Hong Kong Baptist University (FRG1/14-15/050).
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NR 40
TC 8
Z9 8
U1 1
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2017
VL 12
BP 1543
EP 1552
DI 10.2147/CIA.S142109
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA FI0MP
UT WOS:000411620500001
PM 29026292
OA gold, Green Submitted, Green Published
DA 2023-08-17
ER

PT J
AU Lu, YYF
   Bakas, T
   Yang, ZY
   Weaver, MT
   Austrom, MG
   Haase, JE
AF Lu, Yvonne Yueh-Feng
   Bakas, Tamilyn
   Yang, Ziyi
   Weaver, Michael T.
   Austrom, Mary Guerriero
   Haase, Joan E.
TI Feasibility and Effect Sizes of the Revised Daily Engagement of
   Meaningful Activities Intervention for Individuals With Mild Cognitive
   Impairment and Their Caregivers
SO JOURNAL OF GERONTOLOGICAL NURSING
LA English
DT Article
ID LATE-LIFE DEPRESSION; ALZHEIMERS-DISEASE; TREATMENT FIDELITY;
   PERSPECTIVES; VALIDITY; OUTCOMES; PEOPLE; SCALE
AB A nurse-led intervention, Daily Engagement of Meaningful Activities (DEMA), was evaluated for feasibility and effect sizes in a two-group randomized pilot study with 36 patient-caregiver dyads (17 DEMA and 19 attention control). Effect sizes were estimated on 10 outcomes: dyad functional ability awareness congruence; patients' meaningful activity performance and satisfaction, confidence, depressive symptoms, communication satisfaction, physical function, and life satisfaction; and caregivers' depressive symptoms and life changes. High feasibility of DEMA was supported by the following indicators: consent (97.7%), session completion (91.7%), and Time 3 measure completion (97.2%). Compared to the attention control group, the DEMA group had higher dyad congruence in functional ability awareness and life satisfaction 3 months post-intervention and improved physical function at 2 weeks post-intervention. Although DEMA showed high feasibility and benefits on some health-related outcomes, further testing of DEMA in a larger randomized controlled clinical trial is needed.
C1 [Lu, Yvonne Yueh-Feng] Indiana Univ, Sch Nursing, Dept Sci Nursing Care, 600 Barnhill Dr,NU W407, Indianapolis, IN 46202 USA.
   [Bakas, Tamilyn] Univ Cincinnati, Coll Nursing, Cincinnati, OH USA.
   [Yang, Ziyi] Indiana Univ, Sch Nursing, Dept Biostat, Indianapolis, IN 46204 USA.
   [Austrom, Mary Guerriero] Indiana Univ, Sch Nursing, Dept Psychiat, Alzheimers Dis Educ, Indianapolis, IN 46204 USA.
   [Austrom, Mary Guerriero] Indiana Univ, Sch Nursing, Divers Affairs, Indianapolis, IN 46204 USA.
   [Haase, Joan E.] Indiana Univ, Sch Nursing, Dept Nursing Sci Care, Pediat Oncol Nursing, Indianapolis, IN 46204 USA.
   [Haase, Joan E.] RESPECT Signature Ctr, Indiana Alzheimer Dis Ctr, Indianapolis, IN USA.
   [Weaver, Michael T.] Univ Florida, Coll Nursing, Res & Scholarship, Gainesville, FL 32611 USA.
C3 Indiana University System; Indiana University-Purdue University
   Indianapolis; University System of Ohio; University of Cincinnati;
   Indiana University System; Indiana University-Purdue University
   Indianapolis; Indiana University System; Indiana University-Purdue
   University Indianapolis; Indiana University System; Indiana
   University-Purdue University Indianapolis; Indiana University System;
   Indiana University-Purdue University Indianapolis; State University
   System of Florida; University of Florida
RP Lu, YYF (corresponding author), Indiana Univ, Sch Nursing, Dept Sci Nursing Care, 600 Barnhill Dr,NU W407, Indianapolis, IN 46202 USA.
EM yuelu@iu.edu
RI Bakas, Tamilyn/ABC-5664-2020
OI Weaver, Michael/0000-0002-6630-4758
FU National Institutes of Health (NIH); National Institute of Nursing
   Research [5R21NR01375-02]; NIH [O30AG10133]
FX The authors have disclosed no potential conflicts of interest, financial
   or otherwise. This research was supported by the National Institutes of
   Health (NIH) and National Institute of Nursing Research (5R21NR01375-02;
   Y.Y.-F.L.) and in part by NIH O30AG10133.
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NR 33
TC 17
Z9 17
U1 1
U2 19
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0098-9134
EI 1938-243X
J9 J GERONTOL NURS
JI J. Gerontol. Nurs.
PD MAR
PY 2016
VL 42
IS 3
BP 45
EP 58
DI 10.3928/00989134-20160212-08
PG 14
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA DK9ZB
UT WOS:000375289800006
PM 26934973
OA Green Accepted, Green Submitted
DA 2023-08-17
ER

PT J
AU Qi, M
   Zhu, Y
   Zhang, L
   Wu, T
   Wang, J
AF Qi, Ming
   Zhu, Yi
   Zhang, Ling
   Wu, Ting
   Wang, Jie
TI The effect of aerobic dance intervention on brain spontaneous activity
   in older adults with mild cognitive impairment: A resting-state
   functional MRI study
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE mild cognitive impairment; aerobic dance; resting-state functional
   magnetic resonance imaging; amplitude of low-frequency fluctuation
ID LOW-FREQUENCY FLUCTUATION; MEASURED PHYSICAL-ACTIVITY;
   ALZHEIMERS-DISEASE; RISK; AMPLITUDE; EXERCISE; AGE; CONNECTIVITY;
   ASSOCIATION; PLASTICITY
AB The current study aimed to evaluate the effect of a specially designed moderate-intensity aerobic dance (SDMIAD) on brain spontaneous activity in older adults with mild cognitive impairment (MCI) using resting-state functional magnetic resonance imaging (RS-fMRI). A total of 38 subjects with MCI were recruited to the current study and were randomized into two groups: Exercise (EG, n=19) and control (CG, n=19). The EG was treated with a SDMIAD and usual care for 3 months. The CG only received usual care. None of the patients were administered medicine that affected cognition during the intervention. The cognitive assessments and RS-fMRI examination were performed on the two groups at recruitment and after 3 months. The cognitive functions were assessed by various neuropsychological tests. The brain spontaneous activity change was assessed using an index, the amplitude of low-frequency fluctuation (ALFF) of fMRI signal. Cognitive assessments demonstrated that EG had significantly improved results in the Mini-Mental State Examination, the Montreal Cognitive Assessment, Wechsler Memory Scale-Revised Logical Memory (WMS-R LM) and the Symbol Digit Modalities Test (all P<0.05), and the difference in changes in WMS-R LM from baseline to 3 months between the EG and the CG was also statistically significant (P<0.05) after 3 months of SDMIAD. The performance of all the cognitive assessments did not demonstrate significant differences in CG. Compared with baseline, EG exhibited significantly increased ALFF in several areas, including the bilateral fronto-temporal, entorhinal, anterior cingulate and parohippocampal cortex after 3 months of SDMIAD (P<0.05); whereas the CG exhibited significantly increased ALFF only in a few areas, including right temporal and posterior cingulate cortex (P<0.05). The SDMIAD may effectively improve the cognitive function in older adults with MCI. RS-fMRI provided a quantitative method for evaluating the effect of aerobic exercise on cognitive function.
C1 [Qi, Ming; Zhang, Ling; Wang, Jie] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China.
   [Zhu, Yi] Nanjing Med Univ, Affiliated Hosp 1, Dept Rehabil, Nanjing 210029, Jiangsu, Peoples R China.
   [Wu, Ting] Nanjing Med Univ, Affiliated Hosp 1, Dept Neurol, Nanjing 210029, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University
RP Wang, J (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Dept Radiol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM jiewang33@126.com
FU Science and Technology Department of Jiangsu Province [2013-DB13]
FX The current study was supported by the Science and Technology Department
   of Jiangsu Province (grant no. 2013-DB13).
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NR 55
TC 31
Z9 36
U1 6
U2 36
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JAN
PY 2019
VL 17
IS 1
BP 715
EP 722
DI 10.3892/etm.2018.7006
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HG3AN
UT WOS:000454841500099
PM 30651855
OA gold, Green Published, Green Submitted
DA 2023-08-17
ER

PT J
AU Powell, C
   Tomlinson, J
   Quinn, C
   Fylan, B
AF Powell, Catherine
   Tomlinson, Justine
   Quinn, Catherine
   Fylan, Beth
TI Interventions for self-management of medicines for community-dwelling
   people with dementia and mild cognitive impairment and their family
   carers: a systematic review
SO AGE AND AGEING
LA English
DT Article
DE dementia; mild cognitive impairment; medicine; community dwelling;
   systematic review; older people
ID ALZHEIMERS-DISEASE; MEDICATION; ADHERENCE; CAREGIVERS; EDUCATION;
   OUTCOMES; PROGRAM; MODEL
AB Background people with dementia or mild cognitive impairment (MCI) and their family carers face challenges in managing medicines. How medicine self-management could be supported for this population is unclear. This review identifies interventions to improve medicine self-management for people with dementia and MCI and their family carers, and the core components of medicine self-management that they address. Methods a database search was conducted for studies with all research designs and ongoing citation search from inception to December 2021. The selection criteria included community-dwelling people with dementia and MCI and their family carers, and interventions with a minimum of one medicine self-management component. The exclusion criteria were wrong population, not focusing on medicine management, incorrect medicine self-management components, not in English and wrong study design. The results are presented and analysed through narrative synthesis. The review is registered [PROSPERO (CRD42020213302)]. Quality assessment was carried out independently applying the QATSDD quality assessment tool. Results 13 interventions were identified. Interventions primarily addressed adherence. A limited number focused on a wider range of medicine self-management components. Complex psychosocial interventions with frequent visits considered the person's knowledge and understanding, supply management, monitoring effects and side effects and communicating with healthcare professionals, and addressed more resilience capabilities. However, these interventions were delivered to family carers alone. None of the interventions described patient and public involvement. Conclusion interventions, and measures to assess self-management, need to be developed which can address all components of medicine self-management to better meet the needs of people with dementia and MCI and their family carers.
C1 [Powell, Catherine; Tomlinson, Justine; Fylan, Beth] Univ Bradford, Sch Pharm & Med Sci, Room M24,Richmond Bldg,Richmond Rd, Bradford BD7 1DP, W Yorkshire, England.
   [Powell, Catherine; Tomlinson, Justine; Quinn, Catherine; Fylan, Beth] Wolfson Ctr Appl Hlth Res, Bradford, W Yorkshire, England.
   [Tomlinson, Justine] Leeds Teaching Hosp NHS Trust, Med Management & Pharm Serv, Leeds, W Yorkshire, England.
   [Quinn, Catherine] Univ Bradford, Ctr Appl Dementia Studies, Bradford, W Yorkshire, England.
   [Fylan, Beth] Bradford Inst Hlth Res, NIHR Yorkshire & Humber Patient Safety Translat R, Bradford, W Yorkshire, England.
C3 University of Bradford; N8 Research Partnership; White Rose University
   Consortium; University of Leeds; University of Bradford
RP Powell, C (corresponding author), Univ Bradford, Sch Pharm & Med Sci, Room M24,Richmond Bldg,Richmond Rd, Bradford BD7 1DP, W Yorkshire, England.
EM c.powell2@bradford.ac.uk
RI Powell, Catherine E/Q-5375-2018
OI Tomlinson, Justine/0000-0003-3911-0701; Powell,
   Catherine/0000-0001-7590-0247; Fylan, Beth/0000-0003-0599-4537; Quinn,
   Catherine/0000-0001-9553-853X
FU Wolfson Centre for Applied Health Research
FX We would like to thank the patient public involvement members, and
   librarians Maureen Pinder and Jennifer Rowland for their advice on
   carrying out our literature search. This research is supported by the
   Wolfson Centre for Applied Health Research.
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NR 47
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Z9 1
U1 1
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-0729
EI 1468-2834
J9 AGE AGEING
JI Age Ageing
PD MAY 1
PY 2022
VL 51
IS 5
AR afac089
DI 10.1093/ageing/afac089
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 1R3VA
UT WOS:000803299400002
PM 35639800
OA Green Published, hybrid
DA 2023-08-17
ER

PT J
AU Miao, Y
   Cui, L
   Li, JP
   Chen, YX
   Xie, XQ
   Guo, QH
AF Miao, Ya
   Cui, Liang
   Li, Junpeng
   Chen, Yixin
   Xie, Xiangqing
   Guo, Qihao
TI Cognitive Improvement After Multi-Domain Lifestyle Interventions in an
   APOE epsilon 4 Homozygous Carrier with Mild Cognitive Impairment: A Case
   Report and Literature Review
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Alzheimer's disease; APOE; diet; genetic risk effect; mild cognitive
   impairment; nutrition; physical activities; social contacts
ID TO-MODERATE DEMENTIA; GENE-ENVIRONMENT INTERACTION; RANDOMIZED
   CONTROLLED-TRIAL; ALZHEIMERS-DISEASE; APOLIPOPROTEIN-E; MEDITERRANEAN
   DIET; PHYSICAL-ACTIVITY; CHINESE VERSION; RISK; EXERCISE
AB Alzheimer's disease (AD) is a degenerative disease of the central nervous system with insidious onset and chronic progression. The pathogenesis of AD is complex, which is currently considered to be the result of the interaction between genetic and environmental factors. The APOE epsilon 4 is the strongest genetic risk factor for sporadic AD and a risk factor for progression from mild cognitive impairment (MCI) to AD. So far, no effective drugs have been found for the progression of MCI. However, the effects of nonpharmacological interventions such as nutrition, cognitive, and physical exercises on early ADhave received increasing attention. We followed up cognitive assessment scales, A beta-PET and MRI examination of a patient with MCI for 4 years, who carried APOE epsilon 4 homozygous with a clear family history. After 4 years of multi-domain lifestyle interventions including nutrition, socialization, and physical exercises, the patient's cognitive function, especially memory function, improved significantly. Intracerebral amyloid deposition was decreased, and hippocampal atrophy improved. Based on this case, this study reviewed and discussed the interaction of APOE epsilon 4 with the environment in AD research in recent years, as well as the impact and mechanisms of non-pharmaceutical multi-domain lifestyle interventions on MCI or early AD. Both the literature review and this case showed that multi-domain lifestyle interventions may reduce the risk of disease progression by reducing A beta deposition in the brain and other different pathologic mechanisms, which offers promise in brain amyloid-positivity or APOE epsilon 4 carriers.
C1 [Miao, Ya; Cui, Liang; Chen, Yixin; Xie, Xiangqing; Guo, Qihao] Shanghai Jiao Tong Univ, Dept Geriatr, Affiliated Peoples Hosp 6, Shanghai, Peoples R China.
   [Li, Junpeng] Fudan Univ, PET Ctr, Huashan Hosp, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Fudan University
RP Guo, QH (corresponding author), Shanghai Jiao Tong Univ, Dept Geriatr, Affiliated Peoples Hosp 6, Shanghai, Peoples R China.
EM qhguo@sjtu.edu.cn
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NR 73
TC 0
Z9 0
U1 5
U2 7
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2022
VL 89
IS 4
BP 1131
EP 1142
DI 10.3233/JAD-220374
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5K4IE
UT WOS:000869690400001
PM 35988223
DA 2023-08-17
ER

PT J
AU Yang, CC
   Moore, A
   Mpofu, E
   Dorstyn, D
   Li, QW
   Yin, C
AF Yang, Chenchen
   Moore, Ami
   Mpofu, Elias
   Dorstyn, Diana
   Li, Qiwei
   Yin, Cheng
TI Effectiveness of Combined Cognitive and Physical Interventions to
   Enhance Functioning in Older Adults With Mild Cognitive Impairment: A
   Systematic Review of Randomized Controlled Trials
SO GERONTOLOGIST
LA English
DT Review
DE Cognition; Exercise; Dementia; Aged
ID EXERCISE; DEMENTIA; INDIVIDUALS; PERFORMANCE; PROGRESSION; DECLINE; RISK
AB Background and Objectives: Cognitive training delivered in conjunction with physical activity, may help to optimize aging and delay or prevent dementia in individuals with mild cognitive impairment (MCI). However, their efficacy is less well studied compared to pharmaceutical treatments. This systematic review synthesizes the emerging evidence on combined cognitive-physical interventions for enhancing functioning in older adults with MCI, with implications for practice and research.
   Research Design and Methods: We searched the PubMed, PsycINFO, Ageline, Medline, Web of Science and ProQuest databases, and hand-searched articles published between July 2013 and November 2018. Only randomized controlled trials which incorporated cognitive and physical components targeted to individuals with MCI over the age of 50 were eligible. Our search yielded 10 eligible, independent articles.
   Results: Intervention participants with MCI self-reported, or demonstrated, improved functioning across a range of cognitive (global cognitive function, executive function, processing speed, memory, attention, mood, emotion, motivation, brain cortex, orientation), and physical (gait, balance, mobility) outcomes. Interventions which combined cognitive-physical training were comparable to those which isolated these same elements, in terms of their effects on executive function, processing speed, attention, mood, and cardiorespiratory fitness.
   Discussion and Implications: There is preliminary evidence to support the positive effects of multicomponent interventions to improve cognitive-motor abilities in older adults at risk of developing dementia. The strength of this research evidence is, however, limited. Longitudinal studies are needed to determine whether these effects are maintained over time. The optimal intervention intensity and length also need to be established.
C1 [Yang, Chenchen; Moore, Ami; Mpofu, Elias; Li, Qiwei; Yin, Cheng] Univ North Texas, Dept Rehabil & Hlth Serv, 1155 Union Circle 311456, Denton, TX 76203 USA.
   [Mpofu, Elias] Univ Sydney, Clin & Rehabil Sci, Sydney, NSW, Australia.
   [Mpofu, Elias] Univ Johannesburg, Educ Psychol & Inclus Educ, Johannesburg, South Africa.
   [Dorstyn, Diana] Univ Adelaide, Fac Hlth & Med Sci, Sch Psychol, Adelaide, SA, Australia.
C3 University of North Texas System; University of North Texas Denton;
   University of Sydney; University of Johannesburg; University of Adelaide
RP Yang, CC (corresponding author), Univ North Texas, Dept Rehabil & Hlth Serv, 1155 Union Circle 311456, Denton, TX 76203 USA.
EM Chenchen.Yang@unt.edu
OI Dorstyn, Diana/0000-0002-7799-8177
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NR 48
TC 44
Z9 44
U1 2
U2 32
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
EI 1758-5341
J9 GERONTOLOGIST
JI Gerontologist
PD DEC
PY 2020
VL 60
IS 8
BP E633
EP E642
DI 10.1093/geront/gnz149
PG 10
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA PA4IG
UT WOS:000595600900008
PM 31697831
DA 2023-08-17
ER

PT J
AU Lin, MR
   Ma, CY
   Zhu, JF
   Gao, JH
   Huang, L
   Huang, J
   Liu, ZZ
   Tao, J
   Chen, LD
AF Lin, Miaoran
   Ma, Chuyi
   Zhu, Jingfang
   Gao, Jiahui
   Huang, Li
   Huang, Jia
   Liu, Zhizhen
   Tao, Jing
   Chen, Lidian
TI Effects of exercise interventions on executive function in old adults
   with mild cognitive impairment: A systematic review and meta-analysis of
   randomized controlled trials
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Exercise; Mild cognitive impairment; Executive function; Meta -analysis;
   Systematic review; Randomized control trial
ID PHYSICAL-ACTIVITY; INHIBITORY CONTROL; TAI CHI; ALZHEIMERS-DISEASE;
   ELDERLY-WOMEN; DEMENTIA; FITNESS; INDIVIDUALS; PERFORMANCE; DECLINE
AB Aims: To assess the effect of exercise interventions on subdomains of executive function (EF) in older adults with mild cognitive impairment (MCI).Methods: Nine electronic databases were comprehensively searched from their inception to February 2021. Randomized controlled trials examining the effect of exercise training on EF in MCI were included. Results: Twenty-four eligible articles involving 2278 participants were identified. The results showed that ex-ercise interventions had positive benefits on working memory, switching and inhibition in MCI. Subgroup analysis based on exercise prescriptions revealed that both aerobatic exercise and mind-body exercise had similar positive effect size on working memory. However, only mind-body exercise had significant effect on switching. Exercise training with moderate frequency (3-4 times/week) had larger effect size than low frequency (1-2 times/week) and only moderate frequency had positive benefits on switching. Both short (4-12 weeks), medium (13-24 weeks) and long (more than 24 weeks) exercise duration significantly ameliorate working memory and switching, however with short duration having slight larger effect sizes than medium and long.Conclusion: Exercise significantly improves three subdomains of EF in MCI, especially mind-body exercise. Ex-ercise training sticking to at least 4 weeks with 3-4 times a week tends to have larger effect size.
C1 [Lin, Miaoran; Ma, Chuyi; Zhu, Jingfang; Gao, Jiahui; Huang, Li; Huang, Jia; Tao, Jing; Chen, Lidian] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Fujian, Peoples R China.
   [Liu, Zhizhen; Tao, Jing; Chen, Lidian] Fujian Univ Tradit Chinese Med, Natl Local Joint Engn Res Ctr Rehabil Med Technol, Fuzhou, Fujian, Peoples R China.
   [Huang, Jia; Liu, Zhizhen; Tao, Jing; Chen, Lidian] Fujian Key Lab Rehabil Technol, Fuzhou, Fujian, Peoples R China.
   [Huang, Jia; Liu, Zhizhen; Tao, Jing; Chen, Lidian] Fujian Univ Tradit Chinese Med, Minist Educ, Key Lab Orthoped & Traumatol Tradit Chinese Med &, Fuzhou, Fujian, Peoples R China.
   [Chen, Lidian] Fujian Univ Tradit Chinese Med, Fuzhou, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine; Fujian University of Traditional Chinese
   Medicine; Fujian University of Traditional Chinese Medicine
RP Chen, LD (corresponding author), Fujian Univ Tradit Chinese Med, Fuzhou, Fujian, Peoples R China.
EM linmiaoran@163.com; 1217461016@qq.com; 346286192@qq.com;
   1018738674@qq.com; 1114034780@qq.com; jasmine1874@163.com;
   lzz@fjtcm.edu.cn; taojing01@fjtcm.edu.cn; cld@fjtcm.edu.cn
RI Chen, Lidian/GSN-6461-2022; Liu, Zhizhen/AGQ-4570-2022; Tao,
   Jing/GVS-6340-2022
OI Chen, Lidian/0000-0002-8699-0839; Liu, Zhizhen/0000-0001-8934-2805; Tao,
   Jing/0000-0002-4895-2065
FU National Natural Science Foundation of China;  [82030123]
FX Funding This study was supported by the Fundings from the National
   Natural Science Foundation of China (Grant No: 82030123) .
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NR 114
TC 2
Z9 2
U1 21
U2 29
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD DEC
PY 2022
VL 82
AR 101776
DI 10.1016/j.arr.2022.101776
EA NOV 2022
PG 14
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 6H4RC
UT WOS:000885427900005
PM 36332758
DA 2023-08-17
ER

PT J
AU Huang, XX
   Zhao, XY
   Li, B
   Cai, Y
   Zhang, SF
   Wan, QQ
   Yu, F
AF Huang, Xiuxiu
   Zhao, Xiaoyan
   Li, Bei
   Cai, Ying
   Zhang, Shifang
   Wan, Qiaoqin
   Yu, Fang
TI Comparative efficacy of various exercise interventions on cognitive
   function in patients with mild cognitive impairment or dementia: A
   systematic review and network meta-analysis
SO JOURNAL OF SPORT AND HEALTH SCIENCE
LA English
DT Review
DE Cognitive function; Cognitive impairment; Exercise; Network
   meta-analysis
ID OLDER-ADULTS; AEROBIC EXERCISE; ALZHEIMERS-DISEASE; INSTITUTIONALIZED
   PATIENTS; RESISTANCE EXERCISE; WALKING PROGRAM; PEOPLE; ASSOCIATION;
   PERFORMANCE; BALANCE
AB Background: Exercise is a promising nonpharmacological therapy for cognitive dysfunction, but it is unclear which type of exercise is most effective. The objective of this study was to compare and rank the effectiveness of various exercise interventions on cognitive function in patients with mild cognitive impairment (MCI) or dementia and to examine the effects of exercise on the symptoms relevant to cognitive impairment.
   Methods: We searched PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, SPORTDiscus, and PsycInfo through September 2019 and included randomized controlled trials that examined the effectiveness of exercise interventions in patients with MCI or dementia. Primary outcomes included global cognition, executive cognition, and memory cognition. Secondary outcomes included activities of daily living, neuropsychiatric symptoms, and quality of life. Pairwise analyses and network meta-analyses were performed using a random effects model.
   Results: A total of 73 articles from 71 trials with 5606 participants were included. All types of exercise were effective in increasing or maintaining global cognition, and resistance exercise had the highest probability of being the most effective intervention in slowing the decrease in global cognition (standard mean difference (SMD) = 1.05, 95% confidence interval (95%CI): 0.56-1.54), executive function (SMD = 0.85, 95%CI: 0.21-1.49), and memory function (SMD = 0.32, 95%CI: 0.01-0.63) in patients with cognitive dysfunction. Subgroup analyses for patients with MCI revealed different effects, and multicomponent exercise was most likely to be the optimal exercise therapy for preventing the decline of global cognition (SMD = 0.99, 95%CI: 0.44-1.54) and executive function (SMD = 0.72, 95%CI: 0.06-1.38). However, only resistance exercise showed significant effects on memory function for patients with MCI (SMD = 0.35, 95%CI: 0.01-0.69). Exercise interventions also showed various effects on the secondary outcomes.
   Conclusion: Resistance exercise has the highest probability of being the optimal exercise type for slowing cognitive decline in patients with cognitive dysfunction, especially in patients with dementia. Multicomponent exercise tends to be most effective in protecting global cognition and executive function in patients with MCI.
C1 [Huang, Xiuxiu; Zhao, Xiaoyan; Li, Bei; Cai, Ying; Zhang, Shifang; Wan, Qiaoqin] Peking Univ, Sch Nursing, Beijing 100191, Peoples R China.
   [Yu, Fang] Arizona State Univ, Edson Coll Nursing & Hlth Innovat, Phoenix, AZ 85004 USA.
C3 Peking University; Arizona State University; Arizona State
   University-Downtown Phoenix
RP Wan, QQ (corresponding author), Peking Univ, Sch Nursing, Beijing 100191, Peoples R China.
EM qqwan05@163.com
RI Huang, Xiuxiu/AAM-4920-2021
OI Huang, Xiuxiu/0000-0002-5065-9087
FU National Natural Science Foundation of China - National Natural Science
   Foundation of China [81871854]
FX We thank all the experts who provided us with their guid-ance and advice
   on the search strategy. We thank Guohuan Cao for helping us search and
   export literature from the SPORTDiscus database. We also greatly
   appreciate financial support from the National Natural Science
   Foundation of China. This systematic review was funded by the National
   Natural Science Foundation of China (81871854) . The funder did not play
   any role in the preparation or production of the systematic review.
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NR 119
TC 48
Z9 51
U1 40
U2 104
PU SHANGHAI UNIV SPORT
PI SHANGHAI
PA EDITORIAL BOARD, 650 QINGYUANHUAN RD, SHANGHAI, 200438, PEOPLES R CHINA
SN 2095-2546
EI 2213-2961
J9 J SPORT HEALTH SCI
JI J. Sport Health Sci.
PD MAR
PY 2022
VL 11
IS 2
BP 212
EP 223
DI 10.1016/j.jshs.2021.05.003
EA MAR 2022
PG 12
WC Hospitality, Leisure, Sport & Tourism; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics; Sport Sciences
GA 0H3YI
UT WOS:000778670600010
PM 34004389
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Xu, ZJ
   Sun, W
   Zhang, DX
   Chung, VCH
   Sit, RWS
   Wong, SYS
AF Xu, Zijun
   Sun, Wen
   Zhang, Dexing
   Chung, Vincent Chi-Ho
   Sit, Regina Wing-Shan
   Wong, Samuel Yeung-Shan
TI Comparative Effectiveness of Interventions for Global Cognition in
   Patients With Mild Cognitive Impairment: A Systematic Review and Network
   Meta-Analysis of Randomized Controlled Trials
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE cognition; mild cognitive impairment; network meta-analysis; randomized
   controlled trial; systematic review
ID PSYCHOLOGICAL OUTCOMES; STATEMENT; ADHERENCE; EXERCISE; DEMENTIA;
   DECLINE
AB Background: There is a lack of study comprehensively comparing the effects of all existing types of interventions on global cognition among patients with mild cognitive impairment (MCI). Aims: To conduct a network meta-analysis to evaluate the effectiveness of different types of interventions in improving global cognition among MCI patients. Methods: Randomized controlled trials (RCTs) assessing the effects of pharmacological or non-pharmacological interventions on the Mini-Mental State Examination (MMSE) in MCI patients were included. Two authors independently screened the studies and extracted the data. Random-effects network meta-analysis was used to synthesize the data. Results were summarized as mean difference (MD) and corresponding 95% CIs of MMSE in forest plots. Results: Fifty RCTs with 5,944 MCI patients met the inclusion criteria and 49 were included in the network meta-analysis. Compared with the control group, cognition-based intervention (MD = 0.80, 95% CI 0.04-1.57), physical exercise (MD = 1.92, 95% CI 1.19-2.64), combined physical exercise and cognition-based intervention (MD = 1.86, 95% CI 0.60-3.12), and antioxidants (MD = 0.94, 95% CI 0.04-1.83) had positive effects on MMSE in participants with MCI. There was no significant difference between all other interventions included and the control group. Conclusions: This study suggested that cognition-based intervention, physical exercise, combined physical exercise and cognition-based intervention, and antioxidants could be among the most effective interventions on global cognition in older adults with MCI. The availability, acceptability, and cost-effectiveness of interventions should also be taken into consideration when selecting interventions. Registration: PROSPERO CRD42020171985.
C1 [Xu, Zijun; Sun, Wen; Zhang, Dexing; Chung, Vincent Chi-Ho; Sit, Regina Wing-Shan; Wong, Samuel Yeung-Shan] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Wong, SYS (corresponding author), Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China.
EM yeungshanwong@cuhk.edu.hk
RI Chung, Vincent CH/K-2447-2013
OI Chung, Vincent CH/0000-0002-5947-4492; Sun, Wen/0000-0001-9951-405X
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NR 41
TC 4
Z9 4
U1 3
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JUN 18
PY 2021
VL 13
AR 653340
DI 10.3389/fnagi.2021.653340
PG 10
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA TC5ZS
UT WOS:000668721900001
PM 34220484
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Bae, S
   Lee, S
   Lee, S
   Jung, S
   Makino, K
   Harada, K
   Harada, K
   Shinkai, Y
   Chiba, I
   Shimada, H
AF Bae, Seongryu
   Lee, Sangyoon
   Lee, Sungchul
   Jung, Songee
   Makino, Keitaro
   Harada, Kazuhiro
   Harada, Kenji
   Shinkai, Yohei
   Chiba, Ippei
   Shimada, Hiroyuki
TI The effect of a multicomponent intervention to promote community
   activity on cognitive function in older adults with mild cognitive
   impairment: A randomized controlled trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Cognitive function; Community activity; Cognitive activity; Physical
   activity; Social activity
ID SPATIAL WORKING-MEMORY; LEISURE ACTIVITIES; ALZHEIMER-DISEASE; DEMENTIA;
   RISK; TASK; LIFE
AB Objectives: This study aimed to examine the effectiveness of a multicomponent intervention combining physical, cognitive, and social activities developed to promote community activity in improving cognitive function in older adults with mild cognitive impairment (MCI).
   Design: Single-blind randomized controlled trial.
   Setting A total of 83 Japanese older adults with MCI participated in the study from April to September 2017.
   Interventions: Participants were randomly assigned to either the multicomponent intervention group (n = 41), attending 90-minute physical, cognitive, or social activity sessions using community resources twice weekly, or the health education control group (n = 42).
   Outcomes: The primary outcomes were cognitive functions, and the secondary outcomes were grip strength, walking speed, depressive symptoms, physical activities, number of outdoor activities, and conversation time.
   Results: Analysis using linear mixed models revealed significantly greater improvements in the intervention group in spatial working memory (p = 0.024) following intervention compared with the control group. Time spent in moderate-to-vigorous physical activity (p = 0.048) and step count (p = 0.059) decreased from the baseline post-intervention in the control group, whereas the baseline was maintained in the intervention group. No significant between-group differences were found post-intervention in the other primary and secondary outcomes.
   Conclusions: This study showed that a 24-week multicomponent intervention program was effective in improving spatial working memory and maintaining physical activity in older adults with MCI. A follow-up investigation is required to determine whether continuation of physical, cognitive, and social activity can prevent dementia or reverse MCI in older adults.
C1 [Bae, Seongryu; Lee, Sangyoon; Lee, Sungchul; Jung, Songee; Makino, Keitaro; Harada, Kazuhiro; Harada, Kenji; Shinkai, Yohei; Chiba, Ippei; Shimada, Hiroyuki] Natl Ctr Geriatr & Gerontol, Dept Prevent Gerontol, Ctr Gerontol & Social Sci, 7-430 Morioka, Obu, Aichi 4748511, Japan.
   [Bae, Seongryu] Japan Soc Promot Sci, Chiyoda Ku, 5-3-1 Kojimachi, Tokyo 1020083, Japan.
   [Harada, Kazuhiro] Kobe Univ, Grad Sch Human Dev & Environm, 3-11 Tsurukabuto, Kobe, Hyogo 6578501, Japan.
   [Harada, Kenji] Chukyo Univ, Grad Sch Hlth & Sport Sci, 101 Tokodachi, Toyota, Aichi 4700348, Japan.
C3 National Center for Geriatrics & Gerontology; Japan Society for the
   Promotion of Science; Kobe University; Chukyo University
RP Bae, S (corresponding author), Natl Ctr Geriatr & Gerontol, Dept Prevent Gerontol, 7-430 Morioka, Obu, Aichi 4748511, Japan.
EM bae-sr@ncgg.go.jp
RI Makino, Keitaro/AHA-7480-2022; Harada, Kazuhiro/K-2427-2016
OI Makino, Keitaro/0000-0001-9252-8256; Harada,
   Kazuhiro/0000-0002-5798-3912; Shimada, Hiroyuki/0000-0001-8111-6440;
   Chiba, Ippei/0000-0003-1966-3595; jung, songee/0000-0002-9086-8334
FU Japan Society for the Promotion of Science [26242059]; National Center
   for Geriatrics and Gerontology [29-32];  [17F17009]; Grants-in-Aid for
   Scientific Research [26242059] Funding Source: KAKEN
FX Grant-in-aid for scientific research (no. 26242059) from the Japan
   Society for the Promotion of Science; Research Funding for Longevity
   Sciences (29-32) from the National Center for Geriatrics and
   Gerontology; Grant-in-Aid for the Japan Society for the Promotion of
   Science Fellows (17F17009).
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NR 32
TC 46
Z9 51
U1 2
U2 44
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD FEB
PY 2019
VL 42
BP 164
EP 169
DI 10.1016/j.ctim.2018.11.011
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA HK1MV
UT WOS:000457669900028
PM 30670238
DA 2023-08-17
ER

PT J
AU Xue, B
   Xiao, AO
   Luo, XW
   Li, R
AF Xue, Bing
   Xiao, Ao
   Luo, Xianwu
   Li, Rui
TI The effect of a game training intervention on cognitive functioning and
   depression symptoms in the elderly with mild cognitive impairment: A
   randomized controlled trial
SO INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
LA English
DT Article
DE depression; game training; MCI; the elderly
ID LATE-LIFE DEPRESSION; OLDER-ADULTS; PREVALENCE; HEALTH; DEMENTIA;
   EFFICACY; ANXIETY; RISK
AB Objectives This study aimed to explore whether game training could improve cognitive functioning and depression symptoms in the elderly affected by mild cognitive impairment (MCI). Methods A non-blinded randomized controlled trial was conducted. Participants were 72 patients with MCI and depression from a nursing home in Wuhan. Participants were randomized to either the intervention group or the control group (n = 36 each). The intervention group received regular nursing care plus game training for 50 min, three times per week for 8 weeks, whereas the control group received only regular nursing care during the same research period. Cognitive functioning and depression symptoms were tested in both groups at baseline and at the end of the 8-week intervention. We used the Montreal Cognitive Assessment and the 15-item Geriatric Depression Scale to assess cognitive functioning and depression symptoms, respectively. Results The 8-week game training intervention significantly improved the cognitive and depression scores when compared with the control group and baseline scores (p < 0.05). No significant difference was observed in the control group (p > 0.05). Conclusions Our results suggest that the implementation of game training can improve the cognitive functioning and depression symptoms of the elderly with MCI, indicated that can be widely used.
C1 [Xue, Bing; Xiao, Ao; Luo, Xianwu] Wuhan Univ, Sch Hlth Sci, Dept Nursing, 115 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
   [Luo, Xianwu; Li, Rui] Wuhan Univ, Sch Hlth Sci, Dept Hlthcare Management, 115 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Luo, XW (corresponding author), Wuhan Univ, Sch Hlth Sci, Dept Nursing, 115 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.; Li, R (corresponding author), Wuhan Univ, Sch Hlth Sci, Dept Hlthcare Management, 115 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM Luoxw187@126.com; Luoxw187@126.com
OI Xue, Bing/0000-0002-7606-9501
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NR 51
TC 4
Z9 6
U1 10
U2 51
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1049-8931
EI 1557-0657
J9 INT J METH PSYCH RES
JI Int. J. Methods Psychiatr. Res.
PD DEC
PY 2021
VL 30
IS 4
AR e1887
DI 10.1002/mpr.1887
EA JUL 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XF5HA
UT WOS:000675341900001
PM 34291527
OA Green Published
DA 2023-08-17
ER

PT J
AU Dissanayaka, N
   Brooks, D
   Worthy, P
   Mitchell, L
   Pachana, NA
   Byrne, G
   Keramat, SA
   Comans, T
   Bennett, S
   Liddle, J
   Chatfield, MD
   Broome, A
   Oram, J
   Appadurai, K
   Beattie, E
   Au, T
   King, T
   Welsh, K
   Pietsch, A
AF Dissanayaka, Nadeeka
   Brooks, Deborah
   Worthy, Peter
   Mitchell, Leander
   Pachana, Nancy A.
   Byrne, Gerard
   Keramat, Syed Afroz
   Comans, Tracy
   Bennett, Sally
   Liddle, Jacki
   Chatfield, Mark D.
   Broome, Annette
   Oram, Joanne
   Appadurai, Kanaganayagam
   Beattie, Elizabeth
   Au, Tiffany
   King, Teagan
   Welsh, Kimberley
   Pietsch, Ann
TI A single-blind, parallel-group randomised trial of a Technology-assisted
   and remotely delivered Cognitive Behavioural Therapy intervention
   (Tech-CBT) versus usual care to reduce anxiety in people with mild
   cognitive impairment and dementia: study protocol for a randomised trial
SO TRIALS
LA English
DT Article
DE Dementia; Mild cognitive impairment; Anxiety; Psychotherapy; Cognitive
   behavioural therapy; Telehealth; Technology; Digital voice assistant;
   Randomised controlled trial
ID TREATING ANXIETY; STRESS SCALES; DEPRESSION; SYMPTOMS; VALIDATION;
   PREDICTORS; COST; RELIABILITY; INSTRUMENT; INTERVIEW
AB BackgroundAnxiety is commonly experienced by people living with mild cognitive impairment (MCI) and dementia. Whilst there is strong evidence for late-life anxiety treatment using cognitive behavioural therapy (CBT) and delivery via telehealth, there is little evidence for the remote delivery of psychological treatment for anxiety in people living with MCI and dementia. This paper reports the protocol for the Tech-CBT study which aims to investigate the efficacy, cost-effectiveness, usability and acceptability of a technology-assisted and remotely delivered CBT intervention to enhance delivery of anxiety treatment for people living with MCI and dementia of any aetiology.MethodsA hybrid II single-blind, parallel-group randomised trial of a Tech-CBT intervention (n = 35) versus usual care (n = 35), with in-built mixed methods process and economic evaluations to inform future scale-up and implementation into clinical practice. The intervention (i) consists of six weekly sessions delivered by postgraduate psychology trainees via telehealth video-conferencing, (ii) incorporates voice assistant app technology for home-based practice, and (iii) utilises a purpose-built digital platform, My Anxiety Care. The primary outcome is change in anxiety as measured by the Rating Anxiety in Dementia scale. Secondary outcomes include change in quality of life and depression, and outcomes for carers. The process evaluation will be guided by evaluation frameworks. Qualitative interviews will be conducted with a purposive sample of participants (n = 10) and carers (n = 10), to evaluate acceptability and feasibility, as well as factors influencing participation and adherence. Interviews will also be conducted with therapists (n = 18) and wider stakeholders (n = 18), to explore contextual factors and barriers/facilitators to future implementation and scalability. A cost-utility analysis will be undertaken to determine the cost-effectiveness of Tech-CBT compared to usual care.DiscussionThis is the first trial to evaluate a novel technology-assisted CBT intervention to reduce anxiety in people living with MCI and dementia. Other potential benefits include improved quality of life for people with cognitive impairment and their care partners, improved access to psychological treatment regardless of geographical location, and upskilling of the psychological workforce in anxiety treatment for people living with MCI and dementia.
C1 [Dissanayaka, Nadeeka; Brooks, Deborah; Worthy, Peter; Byrne, Gerard; Chatfield, Mark D.; Au, Tiffany; King, Teagan; Welsh, Kimberley] Univ Queensland, Fac Med, UQ Ctr Clin Res, Brisbane, Australia.
   [Dissanayaka, Nadeeka; Mitchell, Leander; Pachana, Nancy A.; Broome, Annette; King, Teagan] Univ Queensland, Fac Hlth & Behav Sci, Sch Psychol, Brisbane, Australia.
   [Byrne, Gerard; Appadurai, Kanaganayagam] Metro North Hosp & Hlth Serv, Brisbane, Australia.
   [Keramat, Syed Afroz; Comans, Tracy] Univ Queensland, Fac Med, Ctr Hlth Serv Res, Brisbane, Australia.
   [Bennett, Sally; Liddle, Jacki] Univ Queensland, Fac Hlth & Behav Sci, Sch Rehabil & Behav Sci, Brisbane, Australia.
   [Liddle, Jacki; Broome, Annette; Oram, Joanne] Metro South Hosp & Hlth Serv, Brisbane, Australia.
   [Beattie, Elizabeth] Queensland Univ Technol, Fac Hlth, Sch Nursing, Brisbane, Australia.
   [Pietsch, Ann] Univ Queensland, Fac Med, UQ Ctr Clin Res, Consumer & Community Involvement Grp, Brisbane, Australia.
C3 University of Queensland; University of Queensland; University of
   Queensland; University of Queensland; Queensland University of
   Technology (QUT); University of Queensland
RP Dissanayaka, N (corresponding author), Univ Queensland, Fac Med, UQ Ctr Clin Res, Brisbane, Australia.; Dissanayaka, N (corresponding author), Univ Queensland, Fac Hlth & Behav Sci, Sch Psychol, Brisbane, Australia.
EM n.dissanayaka@uq.edu.au
RI Keramat, Syed Afroz/AAN-2755-2020; Comans, Tracy/D-9308-2018
OI Keramat, Syed Afroz/0000-0001-8747-9891; Comans,
   Tracy/0000-0003-2840-3496
FU Australian Government MRFF Dementia Aging and Aged Care Mission Grant
   2020; NHMRC Boosting Dementia Research Leadership Fellowship
FX Australian Government MRFF Dementia Aging and Aged Care Mission Grant
   2020. A/Prof Nadeeka Dissanayaka is supported by the NHMRC Boosting
   Dementia Research Leadership Fellowship.The funders played no part in
   study design; and will play no part in the collection, management,
   analysis, and interpretation of data; writing of the report; and the
   decision to submit the report for publication.
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NR 65
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUN 20
PY 2023
VL 24
IS 1
AR 420
DI 10.1186/s13063-023-07381-2
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA J8DI6
UT WOS:001011870200002
PM 37340492
OA gold, Green Submitted, Green Accepted
DA 2023-08-17
ER

PT J
AU Leow, Y
   Rashid, NLBA
   Klainin-Yobas, P
   Zhang, ZM
   Wu, XV
AF Leow, Yihong
   Rashid, Nur Lidiya Binte Abdul
   Klainin-Yobas, Piyanee
   Zhang, Zemiao
   Wu, Xi Vivien
TI Effectiveness of mindfulness-based interventions on mental, cognitive
   outcomes and neuroplastic changes in older adults with mild cognitive
   impairment: A systematic review and meta-analysis
SO JOURNAL OF ADVANCED NURSING
LA English
DT Review; Early Access
DE anxiety; brain neuroplasticity; cognition; cognitive impairment;
   depression; meta-analysis; nurses/midwives/nursing; mild cognitive
   impairment; mindfulness-based interventions; systematic review
ID EMOTION REGULATION; MEDITATION; DEPRESSION; MECHANISMS; REVERSION;
   ANXIETY; STRESS; IMPACT
AB Aims: To evaluate the effectiveness of mindfulness-based interventions (MBIs) on mental and cognitive outcomes including, anxiety, depression, attention, memory, global cognition and neuroplastic changes in older adults with mild cognitive impairment (MCI).Design: Systematic review and meta-analysis.Data source: A three-step search strategy was conducted on eight electronic databases, grey literature and reference lists from inception to February 2022.Review methods: Randomized controlled trials (RCTs) examining MBIs on older adults with MCI were screened and assessed for risk of bias using the Cochrane Risk of Bias Tool. Meta-analysis was conducted using RevMan using a random-effect model. Narrative synthesis was performed for studies where results could not be pooled statistically.Results: Ten RCTs were included in the review. Results suggested that right frontal parietal and left inferior temporal gyrus of the brain showed increased cortical thickness after receiving MBIs. There were significant interaction effects for global efficiency and significant interactions in the insular and gyrus regions. Functional connectivity between the posterior cingulate cortex, bilateral medial prefrontal cortex and left hippocampus were increased in participants undergoing MBIs. Nevertheless, meta-analysis showed non-significant pooled effects, favouring control groups on anxiety, depression, attention, memory and global cognition.Conclusion: This review suggested the potential effects of MBIs in improving cortical thickness and connectivity in regions associated with memory and attention. Nevertheless, the effects of MBIs compared to active control groups on depression, anxiety, attention, memory and global cognition are inconclusive due to the lack of studies and non-significant results.Impact: The review advocates for more rigorous studies with larger sample size and utilizing wait-list controls to evaluate the effects of MBIs. MBIs can be considered as an adjunct with other therapies to further enhance the effect on psychological and cognitive outcomes for older adults with MCI.No Patient or Public Contribution as this is a meta-analysis.
C1 [Leow, Yihong] Woodlands Hlth, Emergency Med, Singapore, Singapore.
   [Rashid, Nur Lidiya Binte Abdul] Woodlands Hlth, Major Operating Theatre, Singapore, Singapore.
   [Klainin-Yobas, Piyanee; Wu, Xi Vivien] Natl Univ Singapore, Alice Lee Ctr Nursing Studies, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Zhang, Zemiao] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Wuhan, Peoples R China.
   [Wu, Xi Vivien] Natl Univ Singapore, NUSMED Hlth Longev Translat Res Programme, Singapore, Singapore.
   [Wu, Xi Vivien] Natl Univ Singapore, Alice Lee Ctr Nursing Studies, Clin Res Ctr, Yong Loo Lin Sch Med, Level 2,Block MD 11,10 Med Dr, Singapore 117597, Singapore.
C3 National University of Singapore; Huazhong University of Science &
   Technology; National University of Singapore; National University of
   Singapore
RP Wu, XV (corresponding author), Natl Univ Singapore, Alice Lee Ctr Nursing Studies, Clin Res Ctr, Yong Loo Lin Sch Med, Level 2,Block MD 11,10 Med Dr, Singapore 117597, Singapore.
EM nurwux@nus.edu.sg
OI WU, Xi Vivien/0000-0002-9264-3630
FU Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine,
   National University of Singapore
FX We would like to thank the generous support from Alice Lee Centre for
   Nursing Studies, Yong Loo Lin School of Medicine, National University of
   Singapore.
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NR 55
TC 0
Z9 0
U1 5
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD 2023 MAY 29
PY 2023
DI 10.1111/jan.15720
EA MAY 2023
PG 17
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA H9XF4
UT WOS:000999401500001
PM 37248564
DA 2023-08-17
ER

PT J
AU Hopkins, J
   Hill, K
   Jacques, A
   Burton, E
AF Hopkins, Jane
   Hill, Keith
   Jacques, Angela
   Burton, Elissa
TI Prevalence, risk factors and effectiveness of falls prevention
   interventions for adults living with Mild Cognitive Impairment in the
   community: A systematic review and meta-analysis
SO CLINICAL REHABILITATION
LA English
DT Review
DE Mild Cognitive Disorder; community-dwelling; accidental fall
ID OLDER-ADULTS; EXECUTIVE FUNCTION; GAIT; DEMENTIA; TIME; FEAR;
   VARIABILITY; PERFORMANCE; MOBILITY; OUTCOMES
AB Objectives: To identify falls prevalence, falls risk factors and evaluate the effectiveness of falls prevention interventions for community-dwelling people with Mild Cognitive Impairment.
   Data sources: Peer-reviewed articles (inception to 4 August 2022) from PubMed, CINAHL, Psyclnfo, EMBASE, Scopus, SportDiscus and the Cochrane library.
   Review methods: All types of methodological approaches were considered. Inclusion criteria were community-dwelling; diagnosis of Mild Cognitive Impairment; aged 50+ years. Interventions needed to include falls prevention programs aiming to reduce falls and/or risk of falls. Outcomes of interest included number and/or rate of falls, falls prevalence and falls risk factors. For controlled trials, any control group was included. Quality assessment was completed using Cochrane's Risk of Bias Tool for randomized controlled trials and the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields for all other studies. Where statistical data pooling was not possible, narrative synthesis was used to present data in tables and figures.
   Results: Forty-seven studies were included. Prevalence of falls was 43% when data were gathered prospectively for 12 months. Confirmed falls risk factors included slow gait, dual-tasking, postural control and non-amnesic Mild Cognitive Impairment. Few studies evaluated interventions to reduce falls. Six meta-analyses were conducted, no significant reduction in falls was found.
   Conclusions: Until further high-quality, adequately powered studies are available to guide practice, best practice guidelines recommend balance training as a core component of falls prevention programs for older people generally, as well as people with Mild Cognitive Impairment.
C1 [Hopkins, Jane; Jacques, Angela; Burton, Elissa] Curtin Univ, Curtin Sch Allied Hlth, GPO Box U1987, Perth, WA 6845, Australia.
   [Hill, Keith] Monash Univ, Sch Primary & Allied Hlth Care, Rehabil Ageing & Independent Living RAIL Res Ctr, Frankston, Vic, Australia.
   [Jacques, Angela] Univ Notre Dame Australia, Inst Hlth Res, Fremantle, WA, Australia.
   [Burton, Elissa] Curtin Univ, enAble Inst, Perth, WA, Australia.
C3 Curtin University; Monash University; University of Notre Dame
   Australia; Curtin University
RP Hopkins, J (corresponding author), Curtin Univ, Curtin Sch Allied Hlth, GPO Box U1987, Perth, WA 6845, Australia.
EM jane.hopkins@postgrad.curtin.edu.au
OI Jacques, Angela/0000-0002-0461-681X
FU Australian Postgraduate Award; Curtin University; National Health and
   Medical Research Council [APP1174739]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by an Australian Postgraduate Award and Curtin University to
   JH; and the National Health and Medical Research Council [APP1174739] to
   EB.
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NR 80
TC 0
Z9 0
U1 2
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-2155
EI 1477-0873
J9 CLIN REHABIL
JI Clin. Rehabil.
PD FEB
PY 2023
VL 37
IS 2
BP 215
EP 243
DI 10.1177/02692155221129832
EA OCT 2022
PG 29
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA 7E1OJ
UT WOS:000863456700001
PM 36189497
DA 2023-08-17
ER

PT J
AU Han, KY
   Tang, ZQ
   Bai, ZR
   Su, WL
   Zhang, H
AF Han, Kaiyue
   Tang, Zhiqing
   Bai, Zirong
   Su, Wenlong
   Zhang, Hao
TI Effects of combined cognitive and physical intervention on enhancing
   cognition in older adults with and without mild cognitive impairment: A
   systematic review and meta-analysis
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE combined cognitive and physical intervention; cognition; older adults;
   mild cognitive impairment; systematic review; meta-analysis
ID ALZHEIMERS-DISEASE; EXERCISE PROGRAM; CONTROLLED-TRIAL; DEPRESSION;
   DEMENTIA; PERFORMANCE
AB Background: Combined cognitive and physical intervention is commonly used as a non-pharmacological therapy to improve cognitive function in older adults, but it is uncertain whether combined intervention can produce stronger cognitive gains than either single cognitive or sham intervention. To address this uncertainty, we performed a systematic review and meta-analysis to evaluate the effects of combined intervention on cognition in older adults with and without mild cognitive impairment (MCI). Methods: We systematically searched eight databases for relevant articles published from inception to November 1, 2021. Randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) were used to compare the effects of the combined intervention with a single cognitive or sham intervention on cognition in older adults with and without MCI aged & GE; 50 years. We also searched Google Scholar, references of the included articles, and relevant reviews. Two independent reviewers performed the article screening, data extraction, and bias assessment. GRADEpro was used to rate the strength of evidence, and RevMan software was used to perform the meta-analysis. Results: Seventeen studies were included in the analysis, comprising eight studies of cognitively healthy older adults and nine studies of older adults with MCI. The meta-analysis showed that the combined intervention significantly improved most cognitive functions and depression (SMD = 0.99, 95% CI 0.54-1.43, p < 0.0001) in older adults compared to the control groups, but the intervention effects varied by cognition domains. However, there was no statistically significant difference in the maintenance between the combined and sham interventions (SMD = 1.34, 95% CI -0.58-3.27, p = 0.17). The subgroup analysis also showed that there was no statistical difference in the combined intervention to improve global cognition, memory, attention, and executive function between cognitive healthy older adults and older adults with MCI. Conclusions: Combined intervention improves cognitive functions in older adults with and without MCI, especially in global cognition, memory, and executive function. However, there was no statistical difference in the efficacy of the combined intervention to improve cognition between cognitive healthy older adults and older adults with MCI. Moreover, the maintenance of the combined intervention remains unclear due to the limited follow-up data and high heterogeneity. In the future, more stringent study designs with more follow-ups are needed further to explore the effects of combined intervention in older adults.Systematic review registration, identifier: CRD42021292490.
C1 [Han, Kaiyue; Tang, Zhiqing; Su, Wenlong; Zhang, Hao] Capital Med Univ, Sch Rehabil, Beijing, Peoples R China.
   [Han, Kaiyue; Tang, Zhiqing; Su, Wenlong; Zhang, Hao] Beijing Boai Hosp, China Rehabil Res Ctr, Beijing, Peoples R China.
   [Bai, Zirong] Univ Melbourne, Fac Med Dent & Hlth Sci, Parkville, Vic, Australia.
   [Su, Wenlong; Zhang, Hao] Univ Hlth & Rehabil Sci, Qingdao, Peoples R China.
   [Zhang, Hao] Shandong Univ, Cheeloo Coll Med, Jinan, Peoples R China.
C3 Capital Medical University; University of Melbourne; University of
   Health & Rehabilitation Sciences; Shandong University
RP Zhang, H (corresponding author), Capital Med Univ, Sch Rehabil, Beijing, Peoples R China.; Zhang, H (corresponding author), Beijing Boai Hosp, China Rehabil Res Ctr, Beijing, Peoples R China.; Zhang, H (corresponding author), Univ Hlth & Rehabil Sci, Qingdao, Peoples R China.; Zhang, H (corresponding author), Shandong Univ, Cheeloo Coll Med, Jinan, Peoples R China.
EM crrczh2020@163.com
FU National Key Research and Development Program of China [2018YFC2001703];
   Capital Health Research and Development of Special Fund [2020-1-6011];
   China Rehabilitation Research Center Key Project [2021ZX-02]
FX This work was supported by the National Key Research and Development
   Program of China (Grant No. 2018YFC2001703), Capital Health Research and
   Development of Special Fund (Grant No. 2020-1-6011), and China
   Rehabilitation Research Center Key Project (Grant No. 2021ZX-02).
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NR 64
TC 3
Z9 3
U1 4
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JUL 19
PY 2022
VL 14
AR 878025
DI 10.3389/fnagi.2022.878025
PG 16
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 3M1CC
UT WOS:000835194500001
PM 35928994
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Dannhauser, TM
   Cleverley, M
   Whitfield, TJ
   Fletcher, B
   Stevens, T
   Walker, Z
AF Dannhauser, Thomas M.
   Cleverley, Martin
   Whitfield, Tim J.
   Fletcher, Ben (C)
   Stevens, Tim
   Walker, Zuzana
TI A complex multimodal activity intervention to reduce the risk of
   dementia in mild cognitive impairment-ThinkingFit: pilot and feasibility
   study for a randomized controlled trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Mild cognitive impairment; Alzheimer's dementia; Dementia prevention;
   Complex activity intervention; Physical activity; Cognitive stimulation;
   Social stimulation
ID OLDER-ADULTS; PHYSICAL-ACTIVITY; ALZHEIMERS-DISEASE; LIFE-STYLE;
   EXERCISE; PROGRAM; WALKING; WEIGHT; HEALTH; LEVEL
AB Background: Dementia affects 35 million people worldwide and is currently incurable. Many cases may be preventable because regular participation in physical, mental and social leisure activities during middle age is associated with up to 47% dementia risk reduction. However, the majority of middle-aged adults are not active enough. MCI is therefore a clear target for activity interventions aimed at reducing dementia risk. An active lifestyle during middle age reduces dementia risk but it remains to be determined if increased activity reduces dementia risk when MCI is already evident. Before this can be investigated conclusively, complex multimodal activity programmes are required that (1) combine multiple health promoting activities, (2) engage people with MCI, and (3) result in sufficient adherence rates.
   Methods: We designed the ThinkingFit programme to engage people with MCI in a complex intervention comprised of three activity components: physical activity, group-based cognitive stimulation (GCST) and individual cognitive stimulation (ICST). Engagement and adherence was promoted by applying specific psychological techniques to enhance behavioural flexibility in an early pre-phase and during the course of the intervention. To pilot the intervention, participants served as their own controls during a 6- to 12-week run-in period, which was followed by 12 weeks of activity intervention.
   Results: Out of 212 MCI patients screened, 163 were eligible, 70 consented and 67 completed the intervention (mean age 74 years). Activity adherence rates were high: physical activity = 71%; GCST = 83%; ICST = 67%. Significant treatment effects (p < .05) were evident on physical health outcomes (decreased BMI and systolic blood pressure, [pre/post values of 26.3/25.9 kg/m(2) and 145/136 mmHg respectively]), fitness (decreased resting and recovery heart rate [68/65 bpm and 75/69 bpm]), and cognition (improved working memory [5.3/6.3 items]).
   Conclusions: We found satisfactory recruitment, retention and engagement rates, coupled with significant treatment effects in elderly MCI patients. It appears feasible to conduct randomized controlled trials of the dementia prevention potential of complex multimodal activity programmes like ThinkingFit.
C1 [Dannhauser, Thomas M.; Walker, Zuzana] UCL, London, England.
   [Dannhauser, Thomas M.; Cleverley, Martin; Whitfield, Tim J.; Stevens, Tim; Walker, Zuzana] North Essex Partnership Univ NHS Fdn Trust, Chelmsford, Essex, England.
   [Fletcher, Ben (C)] Univ Hertfordshire, Hatfield AL10 9AB, Herts, England.
   [Fletcher, Ben (C)] Istanbul Bilgi Univ, Istanbul, Turkey.
C3 University of London; University College London; University of
   Hertfordshire; Istanbul Bilgi University
RP Dannhauser, TM (corresponding author), UCL, London, England.
EM t.dannhauser@ucl.ac.uk
RI Whitfield, Tim/GSI-5806-2022; Dannhauser, Thomas M/C-1263-2011; Walker,
   Zuzana/B-8339-2009
OI Walker, Zuzana/0000-0001-7346-8200; Whitfield, Tim/0000-0002-0305-646X
FU Essex County Council [NEPFT 76/2008/01]; North Essex Partnership
   University NHS Foundation Trust; University College London; UK Dementia
   and Neurodegenerative Diseases Research Network (DeNDRoN)
FX This study was supported by an unrestricted grant from Essex County
   Council (NEPFT 76/2008/01). TD, ZW, TS and MC are employees of the North
   Essex Partnership University NHS Foundation Trust that sponsored the
   study. ZW and TD have academic appointments at University College London
   that supported the study. TW is sponsored by the UK Dementia and
   Neurodegenerative Diseases Research Network (DeNDRoN). We would like to
   thank all the participants and their carers, research staff and staff at
   the Memory and Assessment Service for Mid Essex and the West Essex
   Neurocognitive Clinic, and Essex Adult Community Learning service for
   their contributions to this project.
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NR 52
TC 40
Z9 41
U1 8
U2 52
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 5
PY 2014
VL 14
AR 129
DI 10.1186/1471-244X-14-129
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AI1RP
UT WOS:000336629800001
PM 24886353
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Steiner, GZ
   Mathersul, DC
   MacMillan, F
   Camfield, DA
   Klupp, NL
   Seto, SW
   Huang, Y
   Hohenberg, MI
   Chang, DH
AF Steiner, Genevieve Z.
   Mathersul, Danielle C.
   MacMillan, Freya
   Camfield, David A.
   Klupp, Nerida L.
   Seto, Sai W.
   Huang, Yong
   Hohenberg, Mark I.
   Chang, Dennis H.
TI A Systematic Review of Intervention Studies Examining Nutritional and
   Herbal Therapies for Mild Cognitive Impairment and Dementia Using
   Neuroimaging Methods: Study Characteristics and Intervention Efficacy
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID EVENT-RELATED POTENTIALS; ALZHEIMERS ASSOCIATION WORKGROUPS; VASCULAR
   DEMENTIA; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; SENILE-DEMENTIA;
   GINKGO-BILOBA; DOUBLE-BLIND; DISEASE; MEMORY
AB Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain. This is important for identifying the potential treatment options for target disease cohorts with complex pathophysiologies. The aim of this systematic review was to evaluate study characteristics, intervention efficacy, and the structural and functional neuroimaging methods used in research assessing nutritional and herbal medicines for mild cognitive impairment (MCI) and dementia. Six databases were searched for articles reporting on CMs, dementia, and neuroimaging methods. Data were extracted from 21/2,742 eligible full text articles and risk of bias was assessed. Nine studies examined people with Alzheimer's disease, 7 MCI, 4 vascular dementia, and 1 all-cause dementia. Ten studies tested herbal medicines, 8 vitamins and supplements, and 3 nootropics. Ten studies used electroencephalography (EEG), 5 structural magnetic resonance imaging (MRI), 2 functional MRI (fMRI), 3 cerebral blood flow (CBF), 1 single photon emission tomography (SPECT), and 1 positron emission tomography (PET). Four studies had a low risk of bias, with the majority consistently demonstrating inadequate reporting on randomisation, allocation concealment, blinding, and power calculations. A narrative synthesis approach was assumed due to heterogeneity in study methods, interventions, target cohorts, and quality. Eleven key recommendations are suggested to advance future work in this area.
C1 [Steiner, Genevieve Z.; Klupp, Nerida L.; Seto, Sai W.; Chang, Dennis H.] Univ Western Sydney, NICM, Penrith, NSW 2751, Australia.
   [Steiner, Genevieve Z.; MacMillan, Freya; Klupp, Nerida L.; Seto, Sai W.; Chang, Dennis H.] Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 2751, Australia.
   [Mathersul, Danielle C.] Vet Affairs Palo Alto Hlth Care Syst, War Related Illness & Injury Study Ctr, Palo Alto, CA 94304 USA.
   [Mathersul, Danielle C.] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
   [Mathersul, Danielle C.] Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA.
   [Camfield, David A.] Univ Wollongong, Sch Psychol, Wollongong, NSW 2252, Australia.
   [Camfield, David A.] Univ Wollongong, IHMRI, Wollongong, NSW 2252, Australia.
   [Camfield, David A.] Swinburne Univ Technol, Ctr Human Psychopharmacol, Hawthorn, Vic 3122, Australia.
   [Huang, Yong] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
   [Hohenberg, Mark I.] Univ Western Sydney, Sch Med, Penrith, NSW 2751, Australia.
   [Hohenberg, Mark I.] Campbelltown Hosp, South Western Sydney Area Hlth Serv, Dept Med, Campbelltown, NSW 2560, Australia.
C3 Western Sydney University; Western Sydney University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto
   Health Care System; Stanford University; University of Pennsylvania;
   University of Wollongong; University of Wollongong; Swinburne University
   of Technology; Southern Medical University - China; Western Sydney
   University
RP Steiner, GZ (corresponding author), Univ Western Sydney, NICM, Penrith, NSW 2751, Australia.; Steiner, GZ (corresponding author), Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 2751, Australia.
EM g.steiner@westernsydney.edu.au
RI Steiner-Lim, Genevieve Zara/AFG-5291-2022; Steiner-Lim, Genevieve
   Zara/AAF-1473-2022; Mathersul, Danielle/IQU-8382-2023; Macmillan,
   Freya/AAT-2472-2021
OI Steiner-Lim, Genevieve Zara/0000-0002-8708-6104; Steiner-Lim, Genevieve
   Zara/0000-0002-8708-6104; Mathersul, Danielle/0000-0003-2372-8654;
   Macmillan, Freya/0000-0003-3176-2465; Seto, Sai Wang/0000-0003-0236-4935
FU National Health and Medical Research Council (NHMRC)-Australian Research
   Council (ARC) Dementia Research Development Fellowship [APP1102532]
FX This manuscript was supported by funding from a National Health and
   Medical Research Council (NHMRC)-Australian Research Council (ARC)
   Dementia Research Development Fellowship (APP1102532).
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NR 55
TC 11
Z9 11
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2017
VL 2017
AR 6083629
DI 10.1155/2017/6083629
PG 21
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA EN8IX
UT WOS:000396245200001
PM 28303161
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Yan, ML
   Zhao, YW
   Meng, QY
   Wang, S
   Ding, YW
   Liu, Q
   Yin, HR
   Chen, L
AF Yan, Mingli
   Zhao, Yawei
   Meng, Qiuyan
   Wang, Shuo
   Ding, Yiwen
   Liu, Qian
   Yin, Huiru
   Chen, Li
TI Effects of virtual reality combined cognitive and physical interventions
   on cognitive function in older adults with mild cognitive impairment: A
   systematic review and meta-analysis
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Cognitive dysfunction; Aged; Virtual reality; Meta-analysis
ID DEMENTIA
AB Objective: Combined cognitive and physical interventions based on virtual reality may help delay the progression of MCI to dementia or prevent dementia. However, their efficacy is less well studied compared to pharmaceutical treatments. The purpose of this review was to evaluate the effects of cognitive and physical interventions based on virtual reality on cognitive function (global cognition, memory or executive function/attention) of older adults with mild cognitive impairment.
   Methods: We searched the PubMed, Web of Science, Scopus, Embase, Cochrane Library, PsycINFO, CINAHL and IEEE from inception to 13 May 2021. Only randomized controlled trials which incorporated virtual reality cognitive and physical components targeted to individuals with mild cognitive impairment were eligible. Two researchers independently conducted document retrieval, study selection, data extraction, and methodological quality evaluation.
   Result: 7 randomized controlled trials were included in a total of 8 articles. No studies were rated as having a "high" risk of overall bias. The results of a meta-analysis showed that VR combined cognitive and physical interventions enhanced the global cognitive (MD = 2.66, 95% CI = 1.79-3.54, P = 0.03, I 2 = 68%) abilities of older adults with mild cognitive impairment. The meta-analysis indicated that after virtual reality combined cognitive and physical interventions, effects on memory (SMD = 0.03, 95% CI = 0.60 to 0.55, P = 0.78, I 2 = 0%) and executive function/attention (SMD = 0.19, 95% CI = 0.74 to 0.36, P = 0.09, I 2 = 53%) were not statistically significant.
   Conclusions: The present meta-analysis verifies the potential rehabilitative effects of virtual reality combined cognitive and physical interventions for older adults with mild cognitive impairment. More research is also needed to determine the optimal intensity and timing of interventions in the future.
C1 [Yan, Mingli; Ding, Yiwen; Liu, Qian; Yin, Huiru; Chen, Li] Jilin Univ, Sch Nursing, Changchun 130021, Peoples R China.
   [Zhao, Yawei] Jilin Univ, Coll Basic Med Sci, Dept Pharmacol, Nanomed Engn Lab Jilin Prov, Changchun 130021, Peoples R China.
   [Meng, Qiuyan] China Japan Friendship Hosp, Dept Endocrinol, East Yinghuayuan St, Beijing 100029, Peoples R China.
   [Wang, Shuo] Xuzhou Med Univ, Sch Nursing, Xuzhou 221000, Jiangsu, Peoples R China.
C3 Jilin University; Jilin University; China-Japan Friendship Hospital;
   Xuzhou Medical University
RP Yin, HR; Chen, L (corresponding author), Jilin Univ, Sch Nursing, Changchun 130021, Peoples R China.
EM yanmly@126.com; zhaoyawei@jlu.edu.cn; mengqiuyan407@126.com;
   wangshuo16@mails.jlu.edu.cn; dingyiwen1204@126.com; shiliuqiana@163.com;
   yinhr@jlu.edu.cn; chen_care@126.com
RI liang, liang/IAO-8518-2023
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NR 35
TC 1
Z9 1
U1 16
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD NOV
PY 2022
VL 81
AR 101708
DI 10.1016/j.arr.2022.101708
PG 9
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA D0EO1
UT WOS:000965547200008
PM 35953010
DA 2023-08-17
ER

PT J
AU Gallucci, M
   Mazzetto, M
   Spagnolo, P
   Arico, M
   Bergamelli, C
   Oddo, MG
   Gallo, G
   Astolfo, P
   Di Giorgi, E
   Vanacore, N
AF Gallucci, Maurizio
   Mazzetto, Manuela
   Spagnolo, Pierpaolo
   Arico, Maria
   Bergamelli, Cristina
   Oddo, Maria Grazia
   Gallo, Giovanni
   Astolfo, Paola
   Di Giorgi, Enrico
   Vanacore, Nicola
TI Mild cognitive impairment, from theory to practical intervention:
   "Camminando e leggendo... ricordo" (Walking and reading... I remember),
   an action plan. The Treviso Dementia (TREDEM) Registry
SO ANNALI DELL ISTITUTO SUPERIORE DI SANITA
LA English
DT Article
DE Mild Cognitive Impairment (MCI); Cognitive Frailty (CF); physical
   activity; TREDEM
ID BEING INDEX PGWBI; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; OLDER-ADULTS;
   AEROBIC EXERCISE; WOMENS HEALTH; GRIP STRENGTH; FRAILTY; DECLINE;
   PERFORMANCE
AB Dementia is one of the most disabling health conditions in older people. Increasing attention is paid to the preclinical phase of dementia and to the prevention programs to reduce the number of patients in the future. Aims of the current study are: a) to present Mild Cognitive Impairment (MCI) as a heterogeneous risk factor and to expose the relationship between cognitive impairment and lifestyles such as physical activity, Mediterranean diet, reading and socialization; b) to present a model, called "Camminando e leggendo... ricordo" (CLR), as a practical experience of secondary prevention aimed at MCI older people. The CLR model is composed of a program of physical and reading activities in group to promote healthy lifestyles. Here we present a protocol to evaluate the effectiveness of our intervention model. A multidimensional geriatric assessment will be carried out. A questionnaire for the detection of frailty, disability and for the adherence to the Mediterranean diet will be administered. The Psychological General Well-Being Index (PGWBI) will be used to assess the quality of life. CLR is an intervention model for secondary prevention in MCI subjects. It is the description of a practical proposal aimed at improving lifestyles and reducing the risk of dementia.
C1 [Gallucci, Maurizio; Spagnolo, Pierpaolo; Arico, Maria; Bergamelli, Cristina; Oddo, Maria Grazia] Unita Operat Disturbi Cognitivi & Mem, Ulss 9 Treviso, Treviso, Italy.
   [Mazzetto, Manuela; Gallo, Giovanni] Serv Igiene Sanita Pubbl & Med Comunita, Ulss 9 Treviso, Treviso, Italy.
   [Astolfo, Paola] Med Sport & Esercizio Fis, Ulss 9 Treviso, Treviso, Italy.
   [Gallucci, Maurizio; Spagnolo, Pierpaolo; Arico, Maria; Bergamelli, Cristina; Oddo, Maria Grazia; Di Giorgi, Enrico] Distretto Socio Sanit Sud, Ulss 9 Treviso, Treviso, Italy.
   [Vanacore, Nicola] Ist Super Sanita, Ctr Nazl Epidemiol Sorveglianza & Promoz Salute, Rome, Italy.
C3 ULSS 2 Marca TV; Ospedale Ca' Foncello Treviso; ULSS 2 Marca TV;
   Ospedale Ca' Foncello Treviso; ULSS 2 Marca TV; Ospedale Ca' Foncello
   Treviso; ULSS 2 Marca TV; Ospedale Ca' Foncello Treviso; Istituto
   Superiore di Sanita (ISS)
RP Gallucci, M (corresponding author), Unita Operat Disturbi Cognitivi & Mem, Ulss 9 Treviso, Treviso, Italy.
EM mgallucci@ulss.tv.it
RI Oddo, Mauro/R-3370-2016; Vanacore, Nicola/ABC-7196-2021; Gallucci,
   Maurizio/K-1422-2018
OI Oddo, Mauro/0000-0002-6155-2525; Gallucci, Maurizio/0000-0001-6329-3195
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NR 104
TC 6
Z9 6
U1 0
U2 11
PU PENSIERO SCIENTIFICO
PI ROME
PA VIA SAN GIOVANNI VALDARNO 8, ROME, 00198, ITALY
SN 0021-2571
J9 ANN I SUPER SANITA
JI Ann. Ist. Super. Sanita
PY 2016
VL 52
IS 2
BP 240
EP 248
DI 10.4415/ANN_16_02_16
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA EB2RU
UT WOS:000387210500001
PM 27364399
DA 2023-08-17
ER

PT J
AU Ng, TKS
   Slowey, PD
   Beltran, D
   Ho, RCM
   Kua, EH
   Mahendran, R
AF Ng, Ted Kheng Siang
   Slowey, Paul D.
   Beltran, David
   Ho, Roger C. M.
   Kua, Ee Heok
   Mahendran, Rathi
TI Effect of mindfulness intervention versus health education program on
   salivary All-42 levels in community-dwelling older adults with mild
   cognitive impairment: A randomized controlled trial
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
ID ALZHEIMERS-DISEASE; MICROGLIA; PLASMA; INFLAMMATION; MEDITATION;
   BIOMARKERS
AB Background: Few randomized controlled trials have investigated the effects of mindfulness intervention on older adults diagnosed with mild cognitive impairment (MCI). Specifically, scarce literature exists on the potential benefits of mindfulness intervention on biomarkers representing AD hallmarks. Our previous studies showed the potential of Mindful Awareness Practice (MAP) in improving multiple biomarkers of gut microbiota, systemic inflammation, and synaptic functions. Extending these findings, in this study, we conducted analysis on bio-banked saliva samples, examining whether MAP improved salivary amyloid beta-42 (A beta-42) levels in community-dwelling older adults diagnosed with MCI. We also explored the moderating role of education level, an indicator of cognitive reserve, on intervention effect.
   Methods: A total of 55 community-dwelling older adults diagnosed with MCI were randomized into either the treatment arm, MAP, or the active control arm, the health education program (HEP). Interventions were performed for a total of nine months. Field and laboratory investigators who were blinded to the treatment allocations collected saliva samples at baseline, 3-month, and 9-month follow-ups. Salivary A beta-42 levels were quantified using a commercial assay. Linear-mixed models were used to examine the effect of MAP on salivary A beta-42 levels.
   Results: Compared to the HEP arm, MAP participants had no significantly modified A ss-42 levels throughout the 9-month intervention period, regardless of subgroup analyses stratified by either sex or MCI-subtypes (amnestic and non-amnestic). Exploring the moderating effect of education, participants in the HEP arm with higher education levels had significantly lower salivary A beta-42 at 3-month time-point.
   Discussion: Taken together with our previous findings and other mindfulness interventional studies failing to find a significant effect on peripheral A beta-42, we conclude the non-significant effects of mindfulness intervention on ameliorating peripheral A beta-42 levels. Conversely, participants in the HEP arm with higher cognitive reserve had significantly improved salivary A beta-42, highlighting the role of cognitive reserve in moderating treatment response in MCI.
C1 [Ng, Ted Kheng Siang; Kua, Ee Heok; Mahendran, Rathi] Natl Univ Singapore, Dept Psychol Med, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
   [Slowey, Paul D.; Beltran, David] Oasis Diagnost Corp, Vancouver, WA USA.
   [Slowey, Paul D.] Cent South Univ, Changsha, Peoples R China.
   [Ho, Roger C. M.; Kua, Ee Heok; Mahendran, Rathi] Natl Univ Singapore Hosp, Dept Psychol Med, Singapore, Singapore.
   [Ho, Roger C. M.] Natl Univ Singapore, Biomed Global Inst Healthcare Res & Technol BIGHE, Singapore, Singapore.
   [Ho, Roger C. M.] Nguyen Tat Thanh Univ, Ctr Excellence Behav Med, Ho Chi Minh City, Vietnam.
   [Ho, Roger C. M.] Huaibei Normal Univ, Fac Educ, Huaibei, Peoples R China.
   [Mahendran, Rathi] Duke NUS Med Sch, Acad Dev Dept, 8 Coll Rd, Singapore, Singapore.
C3 National University of Singapore; Central South University; National
   University of Singapore; National University of Singapore; Nguyen Tat
   Thanh University (NTTU); Huaibei Normal University; National University
   of Singapore
RP Ng, TKS (corresponding author), Natl Univ Singapore, Dept Psychol Med, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
EM a0047115@u.nus.edu
RI Ng, Ted Kheng Siang/ABI-1863-2020; Ho, Roger C./ABD-9061-2021; Ho,
   Roger/ABD-8859-2021
OI Ng, Ted Kheng Siang/0000-0001-7348-0410; Ho, Roger
   C./0000-0001-9629-4493; Beltran-Cardona, David/0000-0002-0930-986X;
   Mahendran, Rathi/0000-0003-4213-7163
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NR 36
TC 6
Z9 6
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD APR
PY 2021
VL 136
BP 619
EP 625
DI 10.1016/j.jpsychires.2020.10.038
EA MAR 2021
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RE3ZF
UT WOS:000634095800008
PM 33199051
OA hybrid
DA 2023-08-17
ER

PT J
AU Falck, RS
   Davis, JC
   Best, JR
   Chan, PCY
   Li, LDC
   Wyrough, AB
   Bennett, KJ
   Backhouse, D
   Liu-Ambrose, T
AF Falck, Ryan S.
   Davis, Jennifer C.
   Best, John R.
   Chan, Patrick C. Y.
   Li, Linda C.
   Wyrough, Anne B.
   Bennett, Kimberly J.
   Backhouse, Daniel
   Liu-Ambrose, Teresa
TI Effect of a Multimodal Lifestyle Intervention on Sleep and Cognitive
   Function in Older Adults with Probable Mild Cognitive Impairment and
   Poor Sleep: A Randomized Clinical Trial
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Bright light therapy; chronotherapy; mild cognitive impairment; older
   adults; physical activity; sleep; sleep hygiene
ID CIRCADIAN ACTIVITY RHYTHMS; TEST-RETEST RELIABILITY; PHYSICAL-ACTIVITY;
   BRIGHT LIGHT; QUALITY INDEX; ALZHEIMERS-DISEASE; DAYTIME SLEEPINESS;
   ACTIGRAPHY; VALIDITY; HEALTHY
AB Background: Poor sleep is common among older adults with mild cognitive impairment (MCI) and may contribute to further cognitive decline. Whether multimodal lifestyle intervention that combines bright light therapy (BLT), physical activity (PA), and good sleep hygiene can improve sleep in older adults with MCI and poor sleep is unknown.
   Objective: To assess the effect of a multimodal lifestyle intervention on sleep in older adults with probable MCI and poor sleep.
   Methods: This was a 24-week proof-of-concept randomized trial of 96 community-dwelling older adults aged 65-85 years with probable MCI (<26/30 on the Montreal Cognitive Assessment) and poor sleep (>5 on the Pittsburgh Sleep Quality Index [PSQI]). Participants were allocated to either a multimodal lifestyle intervention (INT); or 2) education + attentional control (CON). INT participants received four once-weekly general sleep hygiene education classes, followed by 20-weeks of: 1) individually-timed BLT; and 2) individually-tailored PA promotion. Our primary outcome was sleep efficiency measured using the MotionWatch8 (c)(MW8). Secondary outcomes were MW8-measured sleep duration, fragmentation index, wake-after-sleep-onset, latency, and PSQI-measured subjective sleep quality.
   Results: There were no significant between-group differences in MW8 measured sleep efficiency at 24-weeks (estimated mean difference [INT - CON]: 1.18%; 95% CI [-0.99, 3.34]), or any other objective-estimate of sleep. However, INT participants reported significantly better subjective sleep quality at 24-weeks (estimated mean difference: -1.39; 95% CI [-2.72, -0.06]) compared to CON.
   Conclusion: Among individuals with probable MCI and poor sleep, a multimodal lifestyle intervention improves subjective sleep quality, but not objectively estimated sleep.
C1 [Falck, Ryan S.; Best, John R.; Chan, Patrick C. Y.; Wyrough, Anne B.; Bennett, Kimberly J.; Backhouse, Daniel; Liu-Ambrose, Teresa] Univ British Columbia, Dept Phys Therapy, Aging Mobil & Cognit Neurosci Lab, Vancouver, BC, Canada.
   [Falck, Ryan S.; Best, John R.; Chan, Patrick C. Y.; Wyrough, Anne B.; Bennett, Kimberly J.; Backhouse, Daniel; Liu-Ambrose, Teresa] Univ British Columbia, Vancouver Coastal Hlth Res Inst, Djavad Mowafaghian Ctr Brain Hlth, Vancouver, BC, Canada.
   [Davis, Jennifer C.] Univ British Columbia, Fac Management, Okanagan Campus, Kelowna, BC, Canada.
   [Li, Linda C.] Univ British Columbia, Arthritis Res Canada, Vancouver, BC, Canada.
   [Falck, Ryan S.; Best, John R.; Chan, Patrick C. Y.; Wyrough, Anne B.; Bennett, Kimberly J.; Backhouse, Daniel; Liu-Ambrose, Teresa] Univ British Columbia, Ctr Hip Hlth & Mobil, Vancouver Coastal Hlth Res Inst, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia;
   Vancouver Coastal Health Research Institute; University of British
   Columbia; Arthritis Research Canada; University of British Columbia;
   University of British Columbia; Vancouver Coastal Health Research
   Institute
RP Liu-Ambrose, T (corresponding author), Univ British Columbia, Dept Phys Therapy, Aging Mobil & Cognit Neurosci Lab, Fac Med,Vancouver Coastal Hlth Res Inst, 212-2177 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
EM teresa.ambrose@ubc.ca
RI Li, Linda C/P-8485-2015
OI Li, Linda C/0000-0001-6280-0511; Wyrough, Anne/0000-0003-0412-0707;
   Best, John R/0000-0001-5775-7053
FU Jack Brown and Family Alzheimer Research Foundation; Vancouver Coastal
   Health Research Institute Innovation and Translational Research Awards
   [F16-01717]; Alzheimer's Society Research Program [15-18]
FX Teresa Liu-Ambrose is a Canada Research Chair (Tier 2) in Physical
   Activity, Mobility, and Cognitive Neuroscience. Funding for this work
   was provided to TLA by the Jack Brown and Family Alzheimer Research
   Foundation, Vancouver Coastal Health Research Institute Innovation and
   Translational Research Awards (F16-01717), and the Alzheimer's Society
   Research Program (15-18). The sponsors had no role in the design,
   methods, data collections, analysis or preparation of this paper.
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NR 70
TC 21
Z9 21
U1 4
U2 19
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2020
VL 76
IS 1
BP 179
EP 193
DI 10.3233/JAD-200383
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA MF4TV
UT WOS:000545337600018
PM 32444553
DA 2023-08-17
ER

PT J
AU Wu, ZY
   Kuang, YX
   Wan, YW
   Shi, J
   Li, SQ
   Xia, R
   Wan, MY
   Chen, SJ
AF Wu, Ziyi
   Kuang, Yuxing
   Wan, Yiwen
   Shi, Jiao
   Li, Shuqian
   Xia, Rui
   Wan, Mingyue
   Chen, Shangjie
TI Effect of a Baduanjin intervention on the risk of falls in the elderly
   individuals with mild cognitive impairment: a study protocol for a
   randomized controlled trial
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Baduanjin; Falls; MCI; Randomized controlled trial; RCT protocol
ID OLDER-ADULTS; BALANCE; PREVENTION
AB Background Falls are a global public problem and may be an important cause of death in older adults. However, older adults with mild cognitive impairment(MCI) are more likely to fall and suffer more damage than older adults with normal cognitive function, which shows the importance of preventing falls. More and more evidence shows that Baduanjin can improve the balance function of the elderly and reduce the risk of falls in the elderly with MCI, but the mechanism is still unclear. The main purpose of this study is to verify the intervention effect of Baduanjin training on the risk of falls in elderly people with MCI and to elucidate the underlying mechanism of Baduanjin training in reducing the risk of falls in MCI patients.
   Methods In this prospective study, outcome assessor-blind, three-arm randomized controlled trial, a total of 72 eligible participants will be randomly allocated (1:1:1) into the 12-week Baduanjin exercise intervention (60 min per session, three sessions per week), the 12-week brisk walking group(60 min per session, three sessions per week) or the 12-week health education group. Primary outcome is the Fall-Risk Self-Assessment Questionnaire(FRQ), and secondary outcomes are fall efficacy index, gait assessment, balance function, lower limb muscle strength, cognitive function, activities of daily living(ADL) and MRI scans. In addition to the MRI scans, which will be measured before and after the intervention,other primary and secondary outcomes will be assessed at baseline, 6 weeks, and 12 weeks (at the end of the intervention) and after an additional 12-week follow-up period. The mixed linear model will be conducted to observe the intervention effects.
   Discussion This trial will investigate the effect of Baduanjin exercise on the prevention of falls in elderly individuals with MCI, explore the imaging mechanism of Baduanjin exercise to reduce the risk of falls in elderly individuals with MCI from the perspective of vestibular neural network, and provide strong evidence for Baduanjin exercise to reduce the risk of falls in elderly individuals with MCI, as well as provide new ideas and approaches for the central mechanism of Traditional Chinese Medicine( TRC) rehabilitation methods to intervene in falls in elderly.
   Trial registration Chictr.org.cn, ID: ChiCTR2200057520. Registered on 14 March 2022, https://www.chictr.org.cn/showproj.html?proj=146592.
C1 [Wu, Ziyi; Kuang, Yuxing; Wan, Mingyue] Southern Med Univ, Sch Clin Med 2, Guangzhou 510515, Peoples R China.
   [Wu, Ziyi; Kuang, Yuxing; Wan, Yiwen; Shi, Jiao; Li, Shuqian; Xia, Rui; Chen, Shangjie] Southern Med Univ, Peoples Hosp Baoan Shenzhen, Sch Clin Med 2, Dept Rehabil, Shenzhen 518101, Peoples R China.
   [Xia, Rui] Guangdong Med Univ, Shunde Maternal & Childrens Hosp, Foshan 528300, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Guangdong Medical University
RP Wan, MY (corresponding author), Southern Med Univ, Sch Clin Med 2, Guangzhou 510515, Peoples R China.; Xia, R; Chen, SJ (corresponding author), Southern Med Univ, Peoples Hosp Baoan Shenzhen, Sch Clin Med 2, Dept Rehabil, Shenzhen 518101, Peoples R China.; Xia, R (corresponding author), Guangdong Med Univ, Shunde Maternal & Childrens Hosp, Foshan 528300, Peoples R China.
EM xiaruitcm@foxmail.com; wanmingyue@smu.edu.cn; csjmesz@sina.com
FU GuangDong Basic and Applied Basic Research Foundation [2021A1515110764];
   Guangzhou Municipal Science and Technology Project [2023A04J0420];
   National Natural Science Foundation of China [81973922]; Shenzhen
   Science and Technology Plan [JCYJ20190809151013581,
   JCYJ20210324110809025, JCYJ20220530142806014]; Sanming Project of
   Medicine in Shenzhen
FX GuangDong Basic and Applied Basic Research Foundation (2021A1515110764).
   Guangzhou Municipal Science and Technology Project (2023A04J0420). The
   National Natural Science Foundation of China (81973922); the Shenzhen
   Science and Technology Plan (JCYJ20190809151013581;
   JCYJ20210324110809025; JCYJ20220530142806014); Sanming Project of
   Medicine in Shenzhen (2017)
CR [Anonymous], FALLS
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NR 39
TC 0
Z9 0
U1 3
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD JUL 13
PY 2023
VL 23
IS 1
AR 233
DI 10.1186/s12906-023-04050-4
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA M4LH1
UT WOS:001029931500001
PM 37442990
OA gold
DA 2023-08-17
ER

PT J
AU Bird, RJ
   Hoggard, N
   Aceves-Martins, M
AF Bird, Rachel Jayne
   Hoggard, Nigel
   Aceves-Martins, Magaly
TI The effect of grape interventions on cognitive and mental performance in
   healthy participants and those with mild cognitive impairment: a
   systematic review of randomized controlled trials
SO NUTRITION REVIEWS
LA English
DT Review
DE cognition; grape; memory; mood; Vitis
ID JUICE; SUPPLEMENTATION; IMPACT; MEMORY
AB Context The prevalence of cognitive and mental health disorders are growing, and existing drug therapies do not treat the underlying cause. Grapes are a flavonoid-rich soft fruit and may therefore be beneficial to cognitive and mental health. Objective To systematically review evidence from randomized controlled trials investigating the acute and chronic effects of grape interventions on measures of cognition and mood in healthy participants and those with mild cognitive impairment. Data Sources MEDLINE, The Cochrane Library and EMBASE were searched. Data Extraction and Analysis Eight studies met the inclusion criteria: one considered acute interventions, 6 assessed chronic effects, and one assessed acute and chronic effects of grapes. The chronic studies found improvements in some cognitive domains (eg, memory, motor skills, or executive function). Acute studies found no consistent effect on memory but saw improvements in reaction time. Conclusions Differences in study design, dosages, and outcome tests hindered between-study comparison. Even so, the results across studies show that grapes can enhance some aspects of cognition, after both acute and chronic interventions. Systematic Review Registration PROSPERO registration no. CRD42020193062.
C1 [Bird, Rachel Jayne; Hoggard, Nigel] Univ Aberdeen, Rowett Inst, Aberdeen, Scotland.
   [Aceves-Martins, Magaly] Univ Aberdeen, Hlth Serv Res Unit, Aberdeen AB25 2ZD, Scotland.
C3 University of Aberdeen; University of Aberdeen
RP Aceves-Martins, M (corresponding author), Univ Aberdeen, Hlth Serv Res Unit, Aberdeen AB25 2ZD, Scotland.
EM magaly.aceves@abdn.ac.uk
RI Aceves-Martins, Magaly/C-2657-2016
OI Aceves-Martins, Magaly/0000-0002-9441-142X
FU Scottish Government Rural and Environment Science and Analytical
   Services (RESAS); University of Aberdeen
FX We are grateful to the Scottish Government Rural and Environment Science
   and Analytical Services (RESAS) and the University of Aberdeen for
   funding.
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NR 24
TC 7
Z9 7
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD FEB 10
PY 2022
VL 80
IS 3
BP 367
EP 380
DI 10.1093/nutrit/nuab025
EA MAY 2021
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA YW7GT
UT WOS:000753584100003
PM 34041549
OA hybrid, Green Published
DA 2023-08-17
ER

PT J
AU Tsatali, M
   Moraitou, D
   Boza, ES
   Tsolaki, M
AF Tsatali, Marianna
   Moraitou, Despina
   Boza, Evgenia Sakka
   Tsolaki, Magdalini
TI Cognition and Functionality Were Not Affected Due to the COVID-19
   Pandemic in People with Mild Cognitive Impairment and AD Dementia
   Attending Digital Non-Pharmacologic Interventions
SO BRAIN SCIENCES
LA English
DT Article
DE COVID-19 pandemic effect; Alzheimer's disease dementia; mild cognitive
   impairment; COVID-19 quarantine
ID DISCRIMINANT VALIDITY; ALZHEIMERS-DISEASE; NORMATIVE DATA; OLDER-ADULTS;
   SCALE
AB Background: The majority of previous studies showed that older adults with mild cognitive impairment (MCI) as well as Alzheimer's disease dementia (ADD) had impaired cognition and mood status, as well as increased behavioral disturbances after the first wave of the COVID-19 pandemic. However, there are still controversial data as regards the multifactorial impact of the restrictive measures on cognition, mood and daily function in older adults with MCI and ADD. Aim: In the current study, the scope is to identify possible deterioration by means of cognitive and functional level due to mood and behavioral alterations during the second quarantine imposed in Greece between November 2020 and May 2021, as well as one year after the second quarantine, in May 2022. Methods: Participants were recruited from the two day centers of the Greek Association of Alzheimer Disease and Related Disorders (GAADRD). They underwent three yearly follow up assessments from May 2020 to May 2022 and participated in cognitive training interventions (through digital online means) during the aforementioned period. Mixed measures analyses of variance as well as path models were used for the study's purposes. Results: The study sample comprised 210 participants (175 people with MCI and 35 people with ADD). The mean age was 71.59 and 77.94 for people with MCI and mild ADD, respectively, whereas the average number of years of education was 12.65 for those with MCI and 9.83 for people with mild ADD. The results show that participants' deterioration rate (D), calculated by means of their performance in neuropsychological and functional assessments between 2020 and 2021 (D1) and 2021 and 2022 (D2), did not change significantly, except for the Rey Auditory Verbal Learning Test (RAVLT), since both groups displayed a larger D2 across the test conditions (immediate recall, fifth trial and delayed recall). Trail Making Test-B (TMT-B) performance, applied only in the MCI group, decreased more in relation to the deterioration rate D2. Additionally, two path models were applied to measure the direct relationships between diagnosis, performance in tests measuring mood and neuropsychiatric disturbances (NPI) and cognition, as measured by the RAVLT, in the 2020-2022 assessments. TMT-B was administered only in the MCI population, and therefore was not included in path models. The results show that participants' scores in RAVLT conditions were related to diagnosis and NPI performance, which was positively affected by diagnosis. No other relationships between RAVLT with mood tests were observed. Conclusions: Our results show that after the second lockdown period, the neuropsychological performance of people with MCI and ADD, calculated by means of their D2, did not change, except from their verbal memory, as well as visual scanning and information processing, measured using the TMT-B. Therefore, it can be assumed that those who were enrolled in digital non-pharmacological interventions during the COVID-19 pandemic home restrictions did not experience increased cognitive and functional deterioration due to mood and behavioral alterations after the pandemic.
C1 [Tsatali, Marianna; Boza, Evgenia Sakka; Tsolaki, Magdalini] Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki 54643, Greece.
   [Tsatali, Marianna; Moraitou, Despina] AUTh, Fac Philosophy, Sch Psychol, Dept Cognit & Expt Psychol, Thessaloniki 54124, Greece.
   [Moraitou, Despina; Tsolaki, Magdalini] AUTh, CIRI, Lab Neurodegenerat Dis, Thessaloniki 54124, Greece.
   [Tsolaki, Magdalini] AUTh, Med Sch, Dept Neurol 1, Thessaloniki 54124, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki
RP Tsatali, M (corresponding author), Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki 54643, Greece.; Tsatali, M (corresponding author), AUTh, Fac Philosophy, Sch Psychol, Dept Cognit & Expt Psychol, Thessaloniki 54124, Greece.
EM mtsatali@yahoo.gr
OI Tsolaki, Magda/0000-0002-2072-8010
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NR 50
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD JUL
PY 2023
VL 13
IS 7
AR 1044
DI 10.3390/brainsci13071044
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA N1YU3
UT WOS:001035058300001
PM 37508975
OA gold
DA 2023-08-17
ER

PT J
AU McPhillips, MV
   Li, JX
   Petrovsky, DV
   Gooneratne, NS
   Aryal, S
   Hodgson, NA
AF McPhillips, Miranda, V
   Li, Junxin
   Petrovsky, Darina, V
   Gooneratne, Nalaka S.
   Aryal, Subhash
   Hodgson, Nancy A.
TI A randomized controlled trial to test a behavioral sleep intervention to
   improve insomnia symptoms in older adults with mild cognitive
   impairment: Multicomponent behavioral sleep intervention (MBSI) protocol
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Insomnia; Older adults; Mild cognitive impairment; Behavioral treatment
ID TELEPHONE INTERVIEW; QUALITY INDEX; VALIDATION; SCALE; PREVALENCE;
   DEPRESSION; EDUCATION; EXERCISE; SF-36
AB Background: Insomnia symptoms in older adults with mild cognitive impairment represent a significant public health burden in terms of impaired quality of life, risks from untreated insomnia, and adverse effects from pharmaceutical insomnia treatment. To address current limitations in the most effective non-pharmacological treatments for insomnia in older adults with mild cognitive impairment, we are conducting a randomized pilot study to test a brief (4-week), tablet-based, personalized, multicomponent behavioral sleep intervention (MBSI) for insomnia, compared to a sleep education control, in a sample of older adults with mild cognitive impairment.Methods: Participants will be randomized in a 1:1 ratio to intervention or control group. Both groups will complete three virtual study data collection visits: baseline, 4-week post-intervention, and 12-week post -intervention follow-up. Key components of the 4-week intervention include sleep hygiene education, stimu-lating meaningful activity during the day and promoting relaxation therapy at night. We will determine pre-liminary immediate (4-week) and sustained efficacy (12-week) of MBSI compared to sleep education on sleep related outcomes and health related quality of life. Additionally, we will explore mechanisms by which the intervention affects sleep and health related quality of life using standardized questionnaires and inflammatory biomarkers.Results: (N/A).Discussion: The findings of the proposed project will inform future, larger scale clinical trials and may provide a novel and innovative way for older adults with mild cognitive impairment to achieve better sleep and health -related quality of life outcomes.
C1 [McPhillips, Miranda, V; Aryal, Subhash; Hodgson, Nancy A.] Univ Penn, Sch Nursing, Philadelphia, PA USA.
   [Li, Junxin] Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA.
   [Petrovsky, Darina, V] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, Sch Nursing, New Brunswick, NJ USA.
   [Gooneratne, Nalaka S.] Univ Penn, Perelman Sch Med, Philadelphia, PA USA.
   [McPhillips, Miranda, V] 418 Curie Blvd 307b, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Johns Hopkins University; Rutgers State
   University New Brunswick; University of Pennsylvania; Pennsylvania
   Medicine
RP McPhillips, MV (corresponding author), Univ Penn, Sch Nursing, Philadelphia, PA USA.; McPhillips, MV (corresponding author), 418 Curie Blvd 307b, Philadelphia, PA 19104 USA.
EM mvarr@upenn.edu
FU National Institute of Nursing Research [K23NR018487]
FX Funding This work was supported by the National Institute of Nursing
   Research (K23NR018487) .
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NR 51
TC 0
Z9 0
U1 7
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD APR
PY 2023
VL 127
AR 107137
DI 10.1016/j.cct.2023.107137
EA MAR 2023
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 9Z5EH
UT WOS:000951163800001
PM 36858255
DA 2023-08-17
ER

PT J
AU Robinson, RAS
   Joshi, G
   Huang, QZ
   Sultana, R
   Baker, AS
   Cai, J
   Pierce, W
   St Clair, DK
   Markesbery, WR
   Butterfield, DA
AF Robinson, Rena A. S.
   Joshi, Gururaj
   Huang, Quanzhen
   Sultana, Rukhsana
   Baker, Austin S.
   Cai, Jian
   Pierce, William
   St Clair, Daret K.
   Markesbery, William R.
   Butterfield, D. Allan
TI Proteomic analysis of brain proteins in APP/PS-1 human double mutant
   knock-in mice with increasing amyloid beta-peptide deposition: Insights
   into the effects of in vivo treatment with N-acetylcysteine as a
   potential therapeutic intervention in mild cognitive impairment and
   Alzheimer's disease
SO PROTEOMICS
LA English
DT Article
DE APP/PS1; Alzheimer disease; Animal proteomics; Mild cognitive
   impairment; N-Acetylcysteine; Oxidative stress; Protein oxidation
ID ACETYL-L-CYSTEINE; OXIDATIVE STRESS; LIPID-PEROXIDATION; GLUTATHIONE
   ELEVATION; MITOCHONDRIAL-DNA; PRECURSOR PROTEIN; TRANSGENIC MICE;
   IDENTIFICATION; DAMAGE; EXPRESSION
AB Proteomics analyses were performed on the brains of wild-type (WT) controls and an Alzheimer's disease (AD) mouse model, APP/PS-1 human double mutant knock-in mice. Mice were given either drinking water or water supplemented with N-acetylcysteine (NAC) (2 mg/kg body weight) for a period of five months. The time periods of treatment correspond to ages prior to A beta deposition (i.e. 4-9 months), resembling human mild cognitive impairment (MCI), and after A beta deposition (i.e. 7-12 months), more closely resembling advancing stages of AD. Substantial differences exist between the proteomes of WT and APP/PS-1 mice at 9 or 12 months, indicating that A beta deposition and oxidative stress lead to downstream changes in protein expression. Altered proteins are involved in energy-related pathways, excitotoxicity, cell cycle signaling, synaptic abnormalities, and cellular defense and structure. Overall, the proteomic results support the notion that NAC may be beneficial for increasing cellular stress responses in WT mice and for influencing the levels of energy-and mitochondria-related proteins in APP/PS-1 mice.
C1 [Butterfield, D. Allan] Univ Kentucky, Dept Chem, Ctr Membrane Sci, Lexington, KY 40506 USA.
   [Cai, Jian; Pierce, William] Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.
   [St Clair, Daret K.] Univ Kentucky, Dept Toxicol, Lexington, KY 40506 USA.
   [Markesbery, William R.; Butterfield, D. Allan] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40506 USA.
   [Markesbery, William R.] Univ Kentucky, Dept Neurol, Lexington, KY 40506 USA.
C3 University of Kentucky; University of Louisville; University of
   Kentucky; University of Kentucky; University of Kentucky
RP Butterfield, DA (corresponding author), Univ Kentucky, Dept Chem, Ctr Membrane Sci, Lexington, KY 40506 USA.
EM dabcns@uky.edu
RI Joshi, Gururaj/G-3819-2012
FU NIH [AG-10836, AG-05119]; University of Kentucky; UNCF-Merck Science
   Initiative
FX This research was supported in part by grants from NIH to D. A. B.
   [AG-10836; AG-05119]. R. A. S. was supported by the University of
   Kentucky Lyman T. Johnson Minority Postdoctoral Fellowship and a
   UNCF-Merck Science Initiative Postdoctoral Fellowship. She is now an
   Assistant Professor of Chemistry at the University of Pittsburgh.
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NR 74
TC 36
Z9 38
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1615-9853
EI 1615-9861
J9 PROTEOMICS
JI Proteomics
PD NOV
PY 2011
VL 11
IS 21
BP 4243
EP 4256
DI 10.1002/pmic.201000523
PG 14
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 850TU
UT WOS:000297223200011
PM 21954051
OA Green Accepted
DA 2023-08-17
ER

PT J
AU Liu, C
   Su, MY
   Jiao, YC
   Ji, Y
   Zhu, SQ
AF Liu, Chang
   Su, Mengyu
   Jiao, Yuchen
   Ji, Yan
   Zhu, Shuqin
TI Effects of Dance Interventions on Cognition, Psycho-Behavioral Symptoms,
   Motor Functions, and Quality of Life in Older Adult Patients With Mild
   Cognitive Impairment: A Meta-Analysis and Systematic Review
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE mild cognitive impairment; dance; elderly; system review; meta-analysis
ID RANDOMIZED-CONTROLLED-TRIAL; DEMENTIA; EXERCISE; BALANCE; AGE; MOBILITY;
   THERAPY
AB Background: Dance interventions are considered beneficial for older patients with mild cognitive impairment in many aspects. We conducted a comprehensive systematic review and meta-analysis to assess the effects of dance on different aspects (cognitive function, emotions, physical function, and quality of life) of this population.</p>
   Methods: A systematic search of PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, Embase, American Psychological Association PsycInfo, ProQuest, Scopus, Cumulative Index to Nursing and Allied Health Literature, the Chinese BioMedical Literature Database, the VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang Data database was performed. Two reviewers independently assessed the study quality.</p>
   Results: Fourteen studies were retrieved from the databases for analysis. The pooled results showed that dance interventions significantly improved global cognition (standardized mean difference [SMD] = 0.73, 95% confidence interval [CI]: 0.47 to 0.99, P < 0.00001), rote memory (mean difference [MD] = -2.12, 95% CI: -4.02 to -0.21, P = 0.03), immediate recall (SMD = 0.54, 95% CI: 0.30 to 0.78, P < 0.0001), delayed recall (SMD = 0.56, 95% CI: 0.26 to 0.86, P = 0.0002) and attention (SMD = 0.38, 95% CI: 0.13 to 0.64, P = 0.003). No significant improvement was found in executive function, language, depression, anxiety, dementia-related behavioral symptoms, motor function, and quality of life.</p>
   Conclusion: Dance interventions benefit most aspects of cognitive functions. The evidence for the effects of dance on psycho-behavioral symptoms, motor function and quality of life remains unclear. More trials with rigorous study designs are necessary to provide this evidence.</p>
C1 [Liu, Chang; Su, Mengyu; Jiao, Yuchen; Ji, Yan; Zhu, Shuqin] Nanjing Med Univ, Sch Nursing, Nanjing, Peoples R China.
C3 Nanjing Medical University
RP Ji, Y; Zhu, SQ (corresponding author), Nanjing Med Univ, Sch Nursing, Nanjing, Peoples R China.
EM kfq5518@163.com; zsq@njmu.edu.cn
RI jiao, yuchen/H-6313-2011
FU Nursing project of superior discipline construction in Jiangsu
   Universities (szbf [2018]) [87]; Nursing science, a key discipline
   project of Jiangsu Province [9]; NSFC [72004099]; Philosophy and Social
   Science Foundation of universities in Jiangsu Province [2017SJB0295]
FX This work was supported by Nursing project of superior discipline
   construction in Jiangsu Universities (szbf [2018] No. 87), Nursing
   science, a key discipline project of Jiangsu Province during the 13th
   Five-Year Plan period (sjy [2016] No. 9), Project Studies on
   Construction of Core Competency Model and Development of Assessment Tool
   for Nurses of Hospice Care supported by NSFC (72004099), and Project
   Comparative study on hospice care mode between China and Canada
   (2017SJB0295) supported by Philosophy and Social Science Foundation of
   universities in Jiangsu Province.
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NR 62
TC 9
Z9 9
U1 11
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD SEP 20
PY 2021
VL 13
AR 706609
DI 10.3389/fnagi.2021.706609
PG 18
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA WA8FL
UT WOS:000703119100001
PM 34616285
OA gold, Green Published
DA 2023-08-17
ER

PT J
AU Bayly, M
   Morgan, D
   Elliot, V
   Kosteniuk, J
   Chow, AF
   Peacock, S
   O'Connell, ME
AF Bayly, Melanie
   Morgan, Debra
   Elliot, Valerie
   Kosteniuk, Julie
   Chow, Amanda Froehlich
   Peacock, Shelley
   O'Connell, Megan E.
TI Does Early-Stage Intervention Improve Caregiver Well-Being or Their
   Ability to Provide Care to Persons With Mild Dementia or Mild Cognitive
   Impairment? A Systematic Review and Meta-Analysis
SO PSYCHOLOGY AND AGING
LA English
DT Review
DE early-stage dementia; mild cognitive impairment; caregiver interventions
ID FAMILY CAREGIVERS; ALZHEIMERS-DISEASE; NONPHARMACOLOGICAL INTERVENTIONS;
   POSITIVE ASPECTS; HEALTH OUTCOMES; PEOPLE; BURDEN; INDIVIDUALS;
   DIAGNOSIS; PROGRAM
AB Interventions for caregivers of persons with dementia are well supported, but it remains unclear whether caregivers benefit from early-stage intervention when caring for persons with mild dementia or mild cognitive impairment (MCI). This systematic review and meta-analysis examined whether early-stage interventions for this population positively affect their well-being and ability to provide care and whether effectiveness varies based on intervention or caregiver/recipient characteristics. Searches of four databases (MEDLINE, EMBASE, PSYCINFO, and CINAHL) yielded 20,722 titles and 1,305 full texts were independently screened. Twenty-two reports representing 18 randomized controlled trial (RCT)/controlled early-stage intervention studies were included for meta-analysis, measuring a variety of outcomes for which effect sizes were calculated using standardized mean differences. Findings suggest that early-stage intervention has a small positive effect on both caregiver well-being and ability to provide care, with the largest effects observed for caregiver anxiety and caring-related distress. Moderator analyses showed no statistically significant difference in effectiveness based on type of intervention (counseling/psychotherapy, psychoeducational, or multicomponent) or individual versus group-based interventions. However, interventions that were caregiver only (vs. dyadic) had larger positive effects on caregiver well-being and ability to provide care. None of the caregiver/recipient characteristics examined (sex, type of relationship, and type of dementia) were related to the effectiveness of early-stage interventions. Although published controlled/RCT trials were limited, findings support efforts to offer early-stage interventions to caregivers of persons with mild dementia or MCI. Further research to determine what intervention types or components are most efficacious would aid the provision of optimal support for caregivers early in their caregiving trajectory.
C1 [Bayly, Melanie; Morgan, Debra; Elliot, Valerie; Kosteniuk, Julie] Univ Saskatchewan, Canadian Ctr Hlth & Safety Agr, Box 23 104 Clin Pl, Saskatoon, SK S7N 5E5, Canada.
   [Chow, Amanda Froehlich] Univ Saskatchewan, Sch Publ Hlth, Saskatoon, SK, Canada.
   [Peacock, Shelley] Univ Saskatchewan, Coll Nursing, Saskatoon, SK, Canada.
   [O'Connell, Megan E.] Univ Saskatchewan, Dept Psychol, Saskatoon, SK, Canada.
C3 University of Saskatchewan; University of Saskatchewan; University of
   Saskatchewan; University of Saskatchewan
RP Bayly, M (corresponding author), Univ Saskatchewan, Canadian Ctr Hlth & Safety Agr, Box 23 104 Clin Pl, Saskatoon, SK S7N 5E5, Canada.
EM melanie.bayly@usask.ca
RI Janson, Patrick/AAC-7581-2022
OI O'Connell, Megan E/0000-0001-6159-4322; Morgan,
   Debra/0000-0002-6344-6822; Bayly, Melanie/0000-0001-5285-839X
FU Canadian Consortium on Neurodegeneration in Aging (CCNA); CIHR;
   Saskatchewan Health Research Foundation; Centre for Aging and Brain
   Health; Alzheimer Society of Canada
FX This research was funded by the Canadian Consortium on Neurodegeneration
   in Aging (CCNA). CCNA is supported by CIHR, with funding from partners
   including the Saskatchewan Health Research Foundation, the Centre for
   Aging and Brain Health, and the Alzheimer Society of Canada.
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NR 79
TC 4
Z9 4
U1 5
U2 12
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0882-7974
EI 1939-1498
J9 PSYCHOL AGING
JI Psychol. Aging
PD NOV
PY 2021
VL 36
IS 7
BP 834
EP 854
DI 10.1037/pag0000642
PG 21
WC Gerontology; Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA WW9BO
UT WOS:000718202900005
PM 34591552
DA 2023-08-17
ER

PT J
AU Ito, E
   Nouchi, R
   Dinet, J
   Cheng, CH
   Husebo, BS
AF Ito, Erika
   Nouchi, Rui
   Dinet, Jerome
   Cheng, Chia-Hsiung
   Husebo, Bettina Sandgathe
TI The Effect of Music-Based Intervention on General Cognitive and
   Executive Functions, and Episodic Memory in People with Mild Cognitive
   Impairment and Dementia: A Systematic Review and Meta-Analysis of Recent
   Randomized Controlled Trials
SO HEALTHCARE
LA English
DT Review
DE music intervention; music therapy; dementia; MCI; nonpharmacological
   therapy; cognitive functions
ID QUALITY-OF-LIFE; ALZHEIMERS-DISEASE; OLDER-ADULTS; THERAPY; MULTICENTER;
   SYMPTOMS; BATTERY
AB Background: Music-based intervention has been used as first-line non-pharmacological treatment to improve cognitive function for people with mild cognitive impairment (MCI) or dementia in clinical practice. However, evidence regarding the effect of music-based intervention on general cognitive function as well as subdomains of cognitive functions in these individuals is scarce. Objective: To evaluate the efficacy of music-based interventions on a wide range of cognitive functions in people with MCI or dementia. Method: We searched the effect of various music therapies using randomized controlled trials on cognitive function using several databases. Studies based on any type of dementia or MCI were combined. The effects of music-based intervention on each cognitive function were pooled by meta-analysis. Results: A total of 19 studies involving n = 1024 participants (mean age ranged from 60 to 87 years old) were included. We found statistically significant improvements in MMSE (general cognitive function), the Frontal Assessment Battery (executive function), and the Auditory Verbal Learning Test (episodic memory). Conclusions: This study provides positive evidence to support music-based interventions for improving a wide range of cognitive functions in older adults with MCI and dementia. Therefore, we recommend increased use of music in people's homes, day care centers and nursing homes. This study was registered with PROSPERO, number 250383.
C1 [Ito, Erika] Tohoku Univ, Sch Med, Sendai, Miyagi 9808575, Japan.
   [Nouchi, Rui] Tohoku Univ, Dept Cognit Hlth Sci, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan.
   [Dinet, Jerome] Univ Lorraine, 2LPN Lab Lorrain Psychol & Neurosci Dynam Comport, F-54000 Nancy, France.
   [Cheng, Chia-Hsiung] Chang Gung Univ, Dept Occupat Therapy, Taoyuan 33302, Taiwan.
   [Cheng, Chia-Hsiung] Chang Gung Univ, Grad Inst Behav Sci, Taoyuan 33302, Taiwan.
   [Cheng, Chia-Hsiung] Chang Gung Univ, Hlth Aging Res Ctr, Taoyuan 33302, Taiwan.
   [Husebo, Bettina Sandgathe] Univ Bergen, Fac Med, Ctr Elderly & Nursing Home Med, Dept Global Publ Hlth & Primary Care, N-5009 Bergen, Norway.
C3 Tohoku University; Tohoku University; Universite de Lorraine; Chang Gung
   University; Chang Gung University; Chang Gung University; University of
   Bergen
RP Nouchi, R (corresponding author), Tohoku Univ, Dept Cognit Hlth Sci, Inst Dev Aging & Canc, Sendai, Miyagi 9808575, Japan.
EM itoeri@hotmail.co.jp; rui@tohoku.ac.jp; jerome.dinet@univ-lorraine.fr;
   ch.cheng@mail.cgu.edu.tw; bettina.husebo@uib.no
OI Cheng, Chia-Hsiung/0000-0001-6654-9387; Dinet,
   Jerome/0000-0002-9546-8604; Ito, Erika/0000-0003-2145-1102
FU Tohoku University-Universite de Lorraine Joint Research Fund 2020; JSPS
   KAKENHI [19H01760, 22H01088]; JSPS Leading Initiative for Excellent
   Young Researchers (LEADER) program
FX This study was supported by a grant from the Tohoku
   University-Universite de Lorraine Joint Research Fund 2020. We were also
   supported by JSPS KAKENHI Grant Numbers 19H01760 and 22H01088
   (Grant-in-Aid for Scientific Research (B). R.N. is supported by the JSPS
   Leading Initiative for Excellent Young Researchers (LEADER) program.
   None of the funding sources had any involvement in the study design,
   collection, analysis, interpretation of data, or writing of the paper.
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NR 73
TC 9
Z9 9
U1 6
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD AUG
PY 2022
VL 10
IS 8
AR 1462
DI 10.3390/healthcare10081462
PG 21
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 4C7DR
UT WOS:000846609600001
PM 36011119
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Cohen, JB
   Marcum, ZA
   Zhang, C
   Derington, CG
   Greene, TH
   Ghazi, L
   Herrick, JS
   King, JB
   Cheung, AK
   Bryan, N
   Supiano, MA
   Sonnen, JA
   Weintraub, WS
   Scharfstein, D
   Williamson, J
   Pajewski, NM
   Bress, AP
AF Cohen, Jordana B.
   Marcum, Zachary A.
   Zhang, Chong
   Derington, Catherine G.
   Greene, Tom H.
   Ghazi, Lama
   Herrick, Jennifer S.
   King, Jordan B.
   Cheung, Alfred K.
   Bryan, Nick
   Supiano, Mark A.
   Sonnen, Joshua A.
   Weintraub, William S.
   Scharfstein, Daniel
   Williamson, Jeff
   Pajewski, Nicholas M.
   Bress, Adam P.
CA Systolic Blood Pressure Interventi
TI Risk of Mild Cognitive Impairment or Probable Dementia in New Users of
   Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme
   Inhibitors A Secondary Analysis of Data From the Systolic Blood Pressure
   Intervention Trial (SPRINT)
SO JAMA NETWORK OPEN
LA English
DT Article
ID INVERSE PROBABILITY; ASSOCIATION; COMBINATION; PREVENTION; CONVERSION;
   ADULTS
AB IMPORTANCE The cardiovascular and renal outcomes of angiotensin-II receptor blocker (ARB) and angiotensin-converting enzyme inhibitor (ACEI) treatment are well-known; however, few studies have evaluated initiation of these agents and cognitive impairment.
   OBJECTIVE To emulate a target trial to evaluate the cognitive outcomes of initiating an ARB- vs ACEI-based antihypertensive regimen in individuals at risk for mild cognitive impairment (MCI) and probable dementia (PD).
   DESIGN, SETTING, AND PARTICIPANTS Active comparator, new-user observational cohort study design using data from the Systolic Blood Pressure Intervention Trial (SPRINT), conducted November 2010 through July 2018. Marginal cause-specific hazard ratios (HRs) and treatment-specific cumulative incidence functions were estimated with inverse probability (IP) weighting to account for confounding. Participants were using neither an ARB nor ACEI at baseline. Data analysis was conducted from April 7, 2021, to April 26, 2022.
   EXPOSURES New users of ARB vs ACEI during the first 12 months of trial follow-up.
   MAIN OUTCOMES AND MEASURES Composite of adjudicated amnestic MCI or PD.
   RESULTS Of 9361 participants, 727 and 1313 new users of an ARB or ACEI, respectively, with well-balanced baseline characteristics between medication exposure groups after inverse probability weighting (mean [SD] age, 67 [9.5] years; 1291 ]63%] male; 240 [33%] Black; 89 [12%] Hispanic; 383 [53%] White; and 15 [2%] other race or ethnicity. In the primary analysis, during a median follow-up of 4.9 years, the inverse probability-weighted rate of amnestic MCI or PD was 4.3 vs 4.6 per 100 person-years among participants initiating ARB vs ACEI (HR, 0.93; 95% CI, 0.76-1.13). In subgroup analyses, new users of an ARB vs ACEI had a lower rate of amnestic MCI or PD among those in the standard systolic blood pressure treatment arm (HR, 0.61; 95% CI, 0.41-0.91) but not in the intensive arm (HR, 1.17; 95% CI, 0.90-1.52) (P = .007 for interaction).
   CONCLUSIONS and Relevance In this observational cohort study of US adults at high cardiovascular disease risk, there was no difference in the rate of amnestic MCI or PD among new users of an ARB compared with ACEI, although 95% CIs were wide.
C1 [Cohen, Jordana B.] Univ Penn, Perelman Sch Med, Renal Electrolyte & Hypertens Div, Dept Med, Philadelphia, PA 19104 USA.
   [Cohen, Jordana B.] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
   [Zhang, Chong; Scharfstein, Daniel] Univ Utah, Spencer Fox Eccles Sch Med, Intermt Healthcare Dept Populat Hlth Sci, Div Biostat, Salt Lake City, UT USA.
   [Derington, Catherine G.; Greene, Tom H.; Herrick, Jennifer S.; King, Jordan B.; Bress, Adam P.] Univ Utah, Spencer Fox Eccles Sch Med, Div Hlth Syst Innovat & Res, Intermt Healthcare Dept Populat Hlth Sci, Salt Lake City, UT USA.
   [Ghazi, Lama] Yale Univ, Sch Med, Clin & Translat Res Accelerator, New Haven, CT USA.
   [Herrick, Jennifer S.; Bress, Adam P.] George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT USA.
   [King, Jordan B.] Kaiser Permanente Colorado, Inst Hlth Res, Aurora, CO USA.
   [Cheung, Alfred K.] Univ Utah, Spencer Fox Eccles Sch Med, Dept Internal Med, Salt Lake City, UT USA.
   [Cheung, Alfred K.] Vet Affairs Salt Lake City Healthcare Syst, Med Serv, Salt Lake City, UT USA.
   [Bryan, Nick] Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA.
   [Supiano, Mark A.] Univ Utah, Spencer Fox Eccles Sch Med, Geriatr Div, Salt Lake City, UT USA.
   [Sonnen, Joshua A.] McGill Univ, Dept Pathol, Montreal, PQ, Canada.
   [Sonnen, Joshua A.] McGill Univ, Dept Neurol, Montreal, PQ, Canada.
   [Sonnen, Joshua A.] McGill Univ, Dept Neurosurg, Montreal, PQ, Canada.
   [Weintraub, William S.] MedStar Hlth Res Inst, Washington, DC USA.
   [Weintraub, William S.] Georgetown Univ, Washington, DC USA.
   [Williamson, Jeff] Wake Forest Univ, Sch Med, Sticht Ctr Hlth Aging & Alzheimers Prevent, Winston Salem, NC 27101 USA.
   [Pajewski, Nicholas M.] Wake Forest Univ, Sch Med, Dept Biostat & Data Sci, Winston Salem, NC 27101 USA.
C3 University of Pennsylvania; Pennsylvania Medicine; University of
   Pennsylvania; Pennsylvania Medicine; Utah System of Higher Education;
   University of Utah; Utah System of Higher Education; University of Utah;
   Yale University; US Department of Veterans Affairs; Kaiser Permanente;
   Utah System of Higher Education; University of Utah; US Department of
   Veterans Affairs; University of Pennsylvania; Pennsylvania Medicine;
   Utah System of Higher Education; University of Utah; McGill University;
   McGill University; McGill University; MedStar Health Research Institute;
   Georgetown University; Wake Forest University; Wake Forest University
RP Cohen, JB (corresponding author), Univ Penn, Perelman Sch Med, 423 Guardian Dr,831 Blockley Hall, Philadelphia, PA 19104 USA.
EM jco@pennmedicine.upenn.edu
RI Cohen, Jordana/S-5435-2016; King, Jordan/GSI-5222-2022; Sonnen,
   Joshua/AAT-5788-2021; Pajewski, Nicholas/J-1096-2019; Sonnen,
   Joshua/H-3738-2016
OI Cohen, Jordana/0000-0003-4649-079X; Ghazi, Lama/0000-0002-9930-3575;
   Sonnen, Joshua/0000-0001-9267-8705; Herrick,
   Jennifer/0000-0001-9257-8843
FU NIA [R01G065805, K76AG059929]; National Heart, Lung, and Blood Institute
   [K23-HL133843, R01-HL153646, R01-HL157108, U01-HL160277]; National
   Center for Advancing Translational Sciences [U01TR003734]; National
   Institute of Diabetes and Digestive and Kidney Diseases [R01DK123104,
   U24DK060990]; American Heart Association Bugher Award; National
   Institute of Neurological Disorders and Stroke [HHSN268200900040C,
   HHSN268200900046C, HHSN268200900047C, HHSN268200900048C,
   HHSN268200900049C, A-HL-13-002-001]; Centers of Biomedical Research
   Excellence award NIGMS [P30GM103337]; National Heart, Lung, and Blood
   Institute; National Institute of Diabetes and Digestive and Kidney
   Diseases; NIA; National Center for Advancing Translational Sciences
   clinical and translational science awards [UL1TR000439, UL1RR025755,
   UL1RR024134, UL1TR000003, UL1RR025771, UL1TR000093, UL1RR025752,
   UL1TR000073, UL1TR001064, UL1TR000050, UL1TR000005, 9U54TR000017-06,
   UL1TR000105-05, UL1 TR000445, UL1TR000075, UL1 TR000064, UL1TR000433]
FX This project was directly supported by NIA grant R01G065805. Dr Marcum
   was supported by grant K76AG059929 from the NIA. Dr Cohen is supported
   by grants K23-HL133843, R01-HL153646, R01-HL157108, and U01-HL160277
   from the National Heart, Lung, and Blood Institute; grant U01TR003734
   from the National Center for Advancing Translational Sciences; grants
   R01DK123104 and U24DK060990 from the National Institute of Diabetes and
   Digestive and Kidney Diseases; and an American Heart Association Bugher
   Award. The Systolic Blood Pressure Intervention Trial was funded by the
   National Heart, Lung, and Blood Institute; the National Institute of
   Diabetes and Digestive and Kidney Diseases; the NIA; and the National
   Institute of Neurological Disorders and Stroke under contracts
   HHSN268200900040C, HHSN268200900046C, HHSN268200900047C,
   HHSN268200900048C, and HHSN268200900049C and interagency agreement
   A-HL-13-002-001. The trial was also supported in part with resources and
   use of facilities through the Department of Veterans Affairs. Additional
   support was provided by the National Institute of General Medical
   Sciences and Centers of Biomedical Research Excellence award NIGMS
   P30GM103337 (awarded to Tulane University) and through the following
   National Center for Advancing Translational Sciences clinical and
   translational science awards: UL1TR000439 (awarded to CaseWestern
   Reserve University); UL1RR025755 (Ohio State University); UL1RR024134
   and UL1TR000003 (University of Pennsylvania); UL1RR025771 (Boston
   University); UL1TR000093 (Stanford University); UL1RR025752,
   UL1TR000073, and UL1TR001064 (Tufts University); UL1TR000050 (University
   of Illinois); UL1TR000005 (University of Pittsburgh); 9U54TR000017-06
   (University of Texas Southwestern Medical Center); UL1TR000105-05
   (University of Utah); UL1 TR000445 (Vanderbilt University); UL1TR000075
   (GeorgeWashington University); UL1 TR000002 (University of California,
   Davis); UL1 TR000064 (University of Florida); and UL1TR000433
   (University of Michigan).
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NR 34
TC 1
Z9 1
U1 0
U2 2
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD JUL 14
PY 2022
VL 5
IS 7
AR e2220680
DI 10.1001/jamanetworkopen.2022.20680
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2Y0GL
UT WOS:000825573100001
PM 35834254
OA Green Published, gold
DA 2023-08-17
ER

PT J
AU Kratzer, A
   Scheel, J
   Wolf-Ostermann, K
   Schmidt, A
   Ratz, K
   Donath, C
   Graessel, E
AF Kratzer, Andre
   Scheel, Jennifer
   Wolf-Ostermann, Karin
   Schmidt, Annika
   Ratz, Katrin
   Donath, Carolin
   Graessel, Elmar
TI The DemWG study: reducing the risk of hospitalisation through a complex
   intervention for people with dementia and mild cognitive impairment
   (MCI) in German shared-housing arrangements: study protocol of a
   prospective, mixed-methods, multicentre, cluster-randomised controlled
   trial
SO BMJ OPEN
LA English
DT Article
DE dementia; delirium; cognitive disorders; geriatric medicine
ID QUALITY-OF-LIFE; MINI-MENTAL-STATE; MANSFIELD AGITATION INVENTORY;
   CHARLSON COMORBIDITY INDEX; NURSING-HOME RESIDENTS; DWELLING
   OLDER-ADULTS; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC INVENTORY; INTERNAL
   CONSISTENCY; CONSTRUCT-VALIDITY
AB Introduction Shared-housing arrangements (SHAs) are small, home-like care environments in Germany. Residents are predominantly people with dementia. The risk for all-cause hospitalisation is consistently higher for people with dementia compared with people without dementia and there is currently no evidence-based intervention to reduce the risk of hospitalisation. Thus, the DemWG study investigates whether a complex intervention is effective in reducing hospitalisation (primary outcome), behavioural and psychological symptoms of dementia and falls and for stabilising cognitive functioning and quality of life in people with dementia and mild cognitive impairment (MCI) in German SHAs. Methods and analysis Based on the UK Medical Research Council framework 'Developing and evaluating complex interventions', a prospective, mixed-methods, multicentre, cluster-randomised controlled trial combining primary and secondary data analyses as well as quantitative and qualitative research methods is being conducted. The intervention consists of three parts: (A) education of nursing staff in SHAs; (B) awareness raising and continuing medical education (CME) of general practitioners; (C) multicomponent non-pharmacological group intervention MAKS-mk+ ('m'=motor training; 'k'=cognitive training; '+'=fall prevention) for people with dementia and MCI. Randomisation is stratified by the German federal states and type of setting (rural vs urban). Neither the trained professionals nor the participants are blinded. Data are collected at baseline and after 6, 12 and 18 months with standardised instruments. Quantitative data will be analysed by multivariate analyses according to the general linear model, qualitative data using qualitative content analysis. Recruitment is still ongoing until 31 December 2020. Ethics and dissemination All procedures were approved by the Ethics Committee of the University of Bremen (Ref. 2019-18-06-3). Informed consent will be obtained before enrolment of participants. Due to findings of previous randomised controlled trials, serious adverse events are not expected. Results will be disseminated in peer-reviewed journal publications and conference presentations.
C1 [Kratzer, Andre; Scheel, Jennifer; Donath, Carolin; Graessel, Elmar] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Ctr Hlth Serv Res Med, Dept Psychiat & Psychotherapy, Erlangen, Germany.
   [Wolf-Ostermann, Karin; Schmidt, Annika; Ratz, Katrin] Univ Bremen, Inst Publ Hlth & Nursing Res IPP, Dept Hlth Care Res, Bremen, Germany.
C3 University of Erlangen Nuremberg; University of Bremen
RP Kratzer, A (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Hosp Erlangen, Ctr Hlth Serv Res Med, Dept Psychiat & Psychotherapy, Erlangen, Germany.
EM andre.kratzer@uk-erlangen.de
OI Kratzer, Andre/0000-0001-7906-3079
FU German Innovation Committee at the Federal Joint Committee; General
   Project Administration by the DLR Project Management Agency [01VSF18054]
FX The DemWG study is supported by grants from the German Innovation
   Committee at the Federal Joint Committee ('Innovationsausschuss beim
   Gemeinsamen Bundesausschuss', Gutenbergstrasse 13, 10587 Berlin) with
   General Project Administration by the DLR Project Management Agency
   (`DLR Projekttrager'; Address: Heinrich-Konen-Strasse 1, 53227 Bonn;
   Phone:+49 228 3821-1020, email:
   innovationsfonds-versorgungsforschung@dlr.de), grant number: 01VSF18054.
   The study protocol has been reviewed by the funding body.
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NR 102
TC 2
Z9 2
U1 1
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 12
AR e041891
DI 10.1136/bmjopen-2020-041891
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA PC7MC
UT WOS:000597179800021
PM 33268431
OA Green Published, gold
DA 2023-08-17
ER

EF