{"text_format":"3","workbook":"xlsx","n_sheets":5,"sheets":["Table 1 Clinical data","Table 2 Treatment outcome"," Table 3 Histology classificati","Table 4 Pathology notes","Table 5 Cytology data"],"read":"whole","date_system":"1900"}

{"sheet":"Table 1 Clinical data","index":0,"n_rows":191,"n_cols":22,"rows_kept":191}
["ID","Country of origin","Age of Patient* ","Infertility in family","Comment on infertility in family","Genetic abnormalities in family","Comment on genetic abnormalities in family","Urological history","Medical history","Testicular volume left (cc)","Testicular volume right (cc)","Inhibin B (ng/L)","FSH (U/L)","Normal scrotal ultrasound","Semen pH","Semen volume (mL)","Semen concentration (x106/mL)","% progressively motile","VCM","% abnormal morfology","Conclusion semen analysis","Probable cause azoospermia"]
["Proband_001","Netherlands",35,"Yes","Mother exposed to Diethylstilbestrol (DES) use and had 3 miscarriage and 1 stillborn","No",null,"Cryptorchidism with orchidectomy right","None",8,"Absent",19,23,"Yes",7.7,0.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_002","Netherlands",36,"No",null,"No",null,"Cryptorchidism bilateral with orchidopexy","None",12,12,22,11,"No: inguinal hernia bilateral",7.8,3.6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_003","Netherlands",39,"No",null,"No",null,"Orchidectomy right, orchitis right, coiling varicocele","Meningitis at age 3, bilateral inguinal hernia ",15,10,21.3,15,"Yes",7.5,4,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_004","Netherlands",35,"No",null,"No",null,"None","None",5,5,"NA",16.5,"No: varicocele left",7.7,4.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_005","Netherlands",35,"Yes","Brother from grandfather had male factor infertility","No",null,"Varicocele right; retrograde ejaculation","None",8,8,28.4,25,"No: epididymis cyst",7.7,0.6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_006","Netherlands",30,"Yes","Parents had difficulties conceiving; age gap of 5 years between patient and his brother, no fertility treatment necessary","Yes","Two sisters of mother are known with intellectual disability","Cryptorchidism with orchidopexy bilateral; hernia inguinalis bilateral; hydrocele","None",20,15,33.4,11,"No: varicocele left",7.8,1.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_007","Netherlands",41,"No","Mother had 2 miscarriages","No",null,"None","None",8,8,13,25,"Yes",7.5,1.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_008","Netherlands",26,"No",null,"No",null,"None","None",15,15,24.6,6.3,"No: microcalcifications bilateral",7.1,3.4,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_009","Netherlands",35,"No",null,"No",null,"Torsio testis unilateral; orchidopexy unilateral","None",10,12,11,25,"Yes",7.5,3.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_010","Netherlands",37,"Yes","Parents had a hard time conceiving, mother had 1 miscarriage","No",null,"None","None",14,12,15.1,16,"Yes",7.5,8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_011","Netherlands",41,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy twice ","Normocytair anemia, parotitis",14,14,10.7,31,"No: inhomogenous lesion left",7.7,3.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_012","Netherlands",31,"No",null,"Possible","1 stillborn sibling, cause unknown","Absence of vas deferens","None",20,20,"ND",3,"Yes",7,1,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_013","Netherlands",28,"Yes","Brother has male factor infertility, also known with cryptorchidism and orchidopexy","No",null,"Cryptorchidism with orchidopexy right","None",12,12,20.3,11,"Yes",7.3,4.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_014","Netherlands",30,"No","Mother had 1 or 2 miscarriages","No",null,"None","None",20,22,13,16,"No: microcalcifications left",7.5,1.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_015","Netherlands",29,"No",null,"No",null,"Cryptorchidism bilateral with orchidopexy","None",16,15,26.6,15,"No: inguinal hernia left",7.5,7.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_016","Netherlands",36,"Unknown",null,"Unknown",null,"None","None",15,15,20.6,25,"Yes",7.5,4.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_017","Netherlands",35,"No",null,"No",null,"None","None",18,18,35,26,"Yes",7.5,4.1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_018","Netherlands",32,"No",null,"No",null,"None","None",20,20,96.7,12,"No: varicocele left; microcalcifications right",7.5,3.4,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_019","Netherlands",31,"Yes","Male cousin has infertility, exact cause unknown","No",null,"Cryptorchidism bilateral with orchidopexy","Congenital muscle dystrophy",14,14,13.9,22,"No: atrophy/shrunk testis bilateral",7.7,1.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_020","Netherlands",31,"No",null,"No",null,"None","None",9,9,18,28,"No: cyst right testis","Unknown","Unknown",0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_021","Netherlands",38,"Yes","Brother of mother conceived a twin with IVF ","No",null,"None","None",15,12,26.6,25.1,"No: varicocele left; microcalcifications right",7.7,4.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_022","Netherlands",38,"Unknown",null,"Unknown",null,"None","None",18,18,19,14,"NA",7.5,4.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_023","Netherlands",29,"No",null,"No",null,"Testis carcinoma; orchidectomy right","None",20,"Absent",31,3.4,"Yes (1 side left)",7.3,3.1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_024","Netherlands",30,"No",null,"No",null,"Cryptorchidism with orchidopexy left; varicocele unilateral","None",8,10,43,31,"No: varicocele left",7.5,5.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_025","Netherlands",31,"No",null,"No",null,"Cryptorchidism bilateral with orchidopexy","None",13,15,9,33,"No: cyst testis left, cyst epididymis right",7.3,2.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_026","Netherlands",32,"No",null,"No",null,"Cryptorchidism bilateral with orchidopexy","None",6,5,24,8.7,"No: varicocele left",7.5,1.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_027","Netherlands",34,"No",null,"Yes","One cousin with intellectual disability","Cryptorchidism with orchidopexy unilateral; hydrocele unilateral; atrophic testis ","None",25,"Not palpable",133,3.1,"No: rough calcifications left",7.7,2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_028","Netherlands",39,"Yes","Brother with fertility problems, also on fathers side of the family ","No",null,"None","None",15,13,"NA",11,"No: inhomogenous lesions bilateral","Unknown","Unknown","Unknown","ND","ND","ND","Extreme oligozoospermia"]
["Proband_029","Netherlands",32,"Yes","Parents had difficulties conceiving, several miscarriages. A brother of mother has children but is known with male factor infertility","No",null,"None","None",10,12,45.8,9.2,"No: microcalcifications left",7.2,4.4,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_030","Netherlands",44,"No",null,"Unknown",null,"None","None",25,15,50,13,"No: varicocele bilateral",7.6,4.5,0,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_031","Netherlands",29,"No",null,"No",null,"Inguinal hernia bilteral","None",15,18,25,"Unknown","No: indefinable tumour left, epididymis cyst right",7.7,2.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_032","Netherlands",27,"No",null,"No",null,"None","None",10,10,22.5,16,"No: varicocele left, microcalcifactions right",7.5,6.1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_033","Netherlands",31,"No",null,"No",null,"None","None",18,18,135,23.8,"No: microcalcifications left",7.6,3.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_034","Unknown",31,"No",null,"No",null,"None","None",15,20,26,11.9,"No: Indefinable tumor left",7.5,1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_035","Netherlands",27,"No",null,"No",null,"Inguinal hernia; cryptorchidism with orchidopexy bilateral","None",15,15,43,11,"NA",7.5,2.1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_036","Netherlands",36,"No","Parents had 4 miscarriages","No",null,"None","None",14,10,15.7,28.2,"No: varicocele left, cyst right",7.7,7.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_037","Netherlands",32,"No",null,"No",null,"Cryptorchidism unilateral; orchidectomy due to non-seminoma ","None","Absent",15,"ND",19,"Yes (1 side left)",7.6,3.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_038","Netherlands",29,"No",null,"No",null,"Cryptorchidism bilateral with orchidpexy ","None",18,18,12,27.1,"Yes",8,1.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_039","Netherlands",30,"Yes","Several uncles and cousins from mothers side of the familie with male factor infertility","No",null,"None","None",12,10,13.4,14.9,"No: epididymis cyst left",7.6,1.6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_040","Netherlands",36,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy","None",6,6,26,37,"No: varicocele left",7.7,2.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_041","Netherlands",35,"No",null,"No",null,"Inguinal hernia unilateral","None",20,15,109,5.2,"No: indefinable tumour bilateral",7.7,1.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_042","Netherlands",33,"No",null,"Yes","Cousin and niece with cystic fibrosis ","None","None",10,10,10.3,28,"No: varicocele left",7.5,9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_043","Netherlands",37,"No",null,"No",null,"None","None",12,15,"NA",17,"Yes",7.5,6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_044","Netherlands",37,"No",null,"No",null,"None","None",10,10,"NA",7.4,"NA","Unknown","Unknown","Unknown","ND","ND","ND","Azoospermia","NOA"]
["Proband_045","Netherlands",32,"No",null,"No",null,"None","None",15,15,16,23,"NA","Unknown","Unknown",0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_046","Netherlands",31,"No",null,"No",null,"Cryptorchidism bilateral with orhidopexy ; inguinal hernia unilateral","None","Not palpable",20,74.9,13,"No: varicocele right",7.5,3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_047","Netherlands",40,"No",null,"No",null,"None","None",13,13,21.7,21,"No: varicocele left",7.5,1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_048","Netherlands",32,"Yes","Brother underwent ICSI treatment 5 times, unsuccessful  ","No",null,"None","None",20,20,"ND",26,"Yes",8.3,4.8,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_049","Netherlands",20,"No",null,"No",null,"Cryptorchidism bilateral with orchidopexy; hydrocele unilateral ","None",15,1,18.8,16,"Yes",7.7,1.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_050","Netherlands",26,"No",null,"No",null,"None","None",15,15,82,10,"No: varicocele left, cyst right",7.7,3.8,0.1,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_051","Netherlands",27,"Yes","Yes uncle and aunt could not conceive, they adopted children, unknown cause","No",null,"Torsio testis unilateral","None","Absent",12,46.3,11,"No: atrophy/shrunk testis left",8,2.1,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_052","Netherlands",28,"Yes","Parents had difficulties conceiving, no fertility treatment","No",null,"Cryptorchidism bilateral with orchidopexy ","None",15,15,76.9,8.2,"Yes",7.7,1.9,1.7,30,0.969,99,"Severe oligoasthenoteratozoospermia"]
["Proband_053","Netherlands",30,"No",null,"No",null,"None","None",12,12,53.85,10,"NA",7.7,3.3,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_054","Netherlands",30,"Yes","Father and brother also known with cryptorchidism","No",null,"Cryptorchidism bilateral with orchidopexy","None",10,10,46.87,15,"No: hydrocele right",7.5,5,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_055","Netherlands",30,"No","Brother and partner had difficulties conceiving and several miscarriages, female factor infertility","No",null,"None","None",15,15,199,3,"No: microcalcifications bilateral",7.5,2.8,0,"ND","ND","ND","Azoospermia","Unclear OA or NOA"]
["Proband_056","Netherlands",27,"No",null,"No",null,"None","None",8,10,45,19,"Yes",7.5,5.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_057","Netherlands",25,"No",null,"No",null,"None","None",15,12,78,21,"No: varicocele left",7.7,3,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_058","Netherlands",32,"Unknown",null,"Unknown",null,"None","None","Unknown","Unknown","NA",8.3,"NA",7.2,4.1,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_059","Netherlands",31,"No",null,"No",null,"None","None",10,10,21.2,24,"No: varicocele left",7.7,1.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_060","Netherlands",29,"No",null,"No",null,"Varicocelectomy left","None",22,22,"ND",4.9,"No: microcalcifications left, hydrocele right",7.5,3.4,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_061","Netherlands",31,"No",null,"No",null,"Cryptorchidism unilateral; orchidopexy unilateral","None",12,15,22.7,29,"Yes",7.3,8.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_062","Netherlands",31,"Yes","Parents had difficulties conceiving, only one child","No",null,"None","None",10,10,91.1,6.6,"Yes",7.5,2.3,0.2,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_063","Netherlands",31,"No",null,"No",null,"None","None",10,10,20,19.3,"No: varicocele left",7.5,4.5,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_064","Netherlands",30,"Unknown",null,"Unknown",null,"None","None","Unknown","Unknown","ND","ND","NA",8,3.7,0.9,18,0.5994,99,"Severe oligozoospermia"]
["Proband_065","Netherlands",32,"No",null,"Yes","Cousin (fathers side) deceased a couple months after birth. Cousin (mothers side) is known with intellectual disability ","None","None",12,12,42.3,7.2,"No: varicocele left, hydrocele right",7.5,2.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_066","Sint Maarten (Caribbean)",30,"Yes","Cousin (mothers side) known with male factor infertility, brother of grandfather (mothers side) childless, cause unknown","No",null,"None","None",15,12,34,9.1,"No: hydrocele right",7.5,3.2,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_067","Netherlands",34,"Unknown",null,"Unknown",null,"Unknown","Did not receive a full consultation in Radboudumc","Unknown","Unknown","NA",0,"NA",7.4,3.3,0.4,47,0.62,99,"Severe oligoteratozoospermia"]
["Proband_068","Netherlands",33,"No",null,"Yes","Cousin has a chromosomal abnormality","None","None",20,20,171,1.7,"Yes",7.7,7.8,0.3,24,0.56,99,"Severe oligoasthenoteratozoospermia"]
["Proband_069","Netherlands",34,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy; inguinal hernia unilateral","None",8,8,13.2,21,"No: varicocele left",7.3,1.7,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_070","Netherlands",29,"No",null,"No",null,"Orchitis, epididymitis both sides","None",15,18,5,44,"Yes",7.5,4.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_071","Netherlands",34,"Unknown",null,"Unknown",null,"None","None","Unknown","Unknown","NA","Unknown","NA",7.2,7.1,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_072","Netherlands",34,"Unknown",null,"Unknown",null,"Unknown","None","Unknown","Unknown","NA","Unknown","NA",7.6,2,1.3,38,0.988,97,"Severe oligoteratozoospermia"]
["Proband_073","Netherlands",34,"No",null,"No",null,"None","None",20,15,"NA",15,"No: epididymis cyst bilateral",7.5,1.1,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_074","Netherlands",30,"No",null,"No",null,"Cryptorchidism with orchidopexy bilateral; glandulair hypospadie correction","None","Unknown","Unknown","ND","ND","NA",7.5,2.8,0.2,19,0.1064,"ND","Severe oligoasthenozoospermia"]
["Proband_075","Netherlands",31,"Yes","Cousin is known with male factor infertility","Yes","Cousin is known with intellectual disability. Brother is known with autism due to asphyxia","None","None",10,10,5,32,"Yes",7.5,1.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_076","Netherlands",35,"No",null,"No",null,"None","None",15,15,86.6,7.4,"Yes","<6.4",0.3,0,"ND","ND","ND","Azoospermia","Unclear OA or NOA"]
["Proband_077","Netherlands",35,"No",null,"No",null,"Cryptorchism right, conservative treatment","None","Unknown","Unknown",24.3,32,"No: varicocele left, inguinal hernia right",7.6,1.3,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_078","Netherlands",35,"No",null,"Yes","Sister with Turners syndrome (45X)","Hypogonadotrope hypogonadism","Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS); progressive hearingloss",null,null,"NA",8.6,"NA",8.8,4.7,0.4,20,0.376,99,"Severe oligoasthenozoospermia"]
["Proband_079","Netherlands",32,"No",null,"No",null,"Cryptorchism bilateral with orchidpexy","None",14,14,17.6,0.73,"NA",7.7,1.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_080","Netherlands",33,"Yes","Two brothers also have cryptorchidism, one of them is known with male factor infertility and is starting fertility treatment","No",null,"Inguinal hernia unilateral; cryptorchidism bilateral with orchidopexy","None",12,12,33.3,20,"Yes",7.4,7.2,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_081","Netherlands",35,"No",null,"No",null,"Cryptchism unilateral with orchidopexy; inguinal hernia unilateral","None","Unknown","Unknown","NA","Unknown","NA",8,4.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_082","Netherlands",30,"No",null,"No",null,"Varicocele bilateral","None",12,10,45,10,"NA",7.2,6.5,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_083","Netherlands",34,"Yes","Parents known with female and male factor infertility and received fertility treatment","No",null,"Inguinal hernia unilateral; cryptorchidism with orchidopexy unilateral; hydrocele unilateral","None",25,20,189,5.8,"Yes",7.4,3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_084","Netherlands",36,"No",null,"No",null,"Spermatocele unilateral","None",15,15,189,4.2,"No: cyst left",7.2,0.7,0,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_085","Netherlands",29,"No",null,"Yes","Cousin with intellectual disability","None","None","Unknown","Unknown","ND","ND","NA",7.7,5.4,0.5,17,0.459,99,"Severe oligoasthenoteratozoospermia"]
["Proband_086","Netherlands",37,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy; inguinal hernia unilateral","None",25,25,251,2.9,"No: cyst left, epididiymis cyst right",7.5,2.5,0,"ND","ND","ND","Azoospermia","Unclear OA or NOA"]
["Proband_087","Netherlands",27,"No",null,"Yes","Cousin with a congenital muscle disease","None","None","Unknown","Unknown","ND",16.7,"NA",8.5,4.8,0.7,20,0.672,"ND","Severe oligoasthenozoospermia"]
["Proband_088","Netherlands",30,"No",null,"No",null,"Cryptochidism bilateral with orchidopexy","None",10,12,18,40,"Yes",7.4,5.8,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_089","Netherlands",36,"Yes","Parents had two miscarriages and never managed to have a third child","No","Younger brother died due to a braintumor","None","None",15,18,"NA",14,"Yes",7.5,1.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_090","Unknown",33,"No",null,"No",null,"None","None",15,10,"ND",11,"No: cyst epidydimis right ",7.7,2,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_091","Netherlands",31,"Yes","Brother and partner are known with infertility","Unknown",null,"Cryptorchidism conservative treatment","Nose cancer with radiotherapy",10,10,33,9,"Yes",7.5,5.2,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_092","Netherlands",35,"No",null,"No",null,"None","None",16,14,33.3,28.5,"Yes",7.5,2.6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_093","Netherlands",31,"Yes","Brother has male factor infertility","No",null,"None","None","Unknown","Unknown",77,4.5,"Yes",7.7,3,0.1,15,0.045,"ND","Severe oligoasthenozoospermia"]
["Proband_094","Netherlands",34,"Yes","Father has male factor infertility (teratozoospermia)","No",null,"Cryptorchidism unilateral with orchidopexy ","None",12,10,"ND",14.7,"No: hydrocele left",7.7,3.2,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_095","Netherlands",31,"No",null,"Yes","Cousin deceased shortly after birth due to a genetic blistering skin disease","None","None","Unknown","Unknown",266,2.8,"No: varicocele left",7.5,3.3,0,"ND","ND","ND","Azoospermia","Unclear OA or NOA"]
["Proband_096","Netherlands",35,"No",null,"No",null,"None","None",10,10,5,25,"Yes",7.7,2.2,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_097","Netherlands",37,"No",null,"No",null,"None","None",20,20,161,3.8,"NA",7.2,3.8,0,"ND","ND","ND","Azoospermia","Unclear OA or NOA"]
["Proband_098","Netherlands",32,"No",null,"No",null,"Cryptorchidism bilateral with orchidopexy","None",20,20,85,8.3,"Yes",7.2,5.1,1,36,1.84,99,"Severe oligoteratozoospermia"]
["Proband_099","Netherlands",29,"Unknown",null,"Unknown",null,"None","None","Unknown","Unknown","ND","ND","NA",7.7,3.9,0.7,6,0.16,"ND","Severe oligoasthenozoospermia"]
["Proband_100","Netherlands",30,"Yes","Uncle and two cousins are known with infertility, cause unknown ","No",null,"Cryptorchidism with orchidopexy unilateral","None","Unknown","Unknown","ND","ND","NA",7.6,4.7,2.5,6,0.71,99,"Severe oligoasthenoteratozoospermia"]
["Proband_101","Netherlands",38,"Unknown",null,"Unknown",null,"Unknown","Did not receive a full consultation in Radboudumc","Unknown","Unknown","NA","Unknown","NA",7.2,2.7,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_102","Netherlands",31,"No",null,"No",null,"None","None",20,20,39,18,"NA",7.7,3.5,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_103","Unknown",39,"No",null,"No",null,"None","None","Unknown","Unknown","NA",0,"NA",7.7,4.4,2.6,51,"ND",99,"Severe oligoteratozoospermia"]
["Proband_104","Netherlands",39,"No",null,"No",null,"None","None","Unknown","Unknown","NA",12,"NA",7.5,2.8,1.2,25,0.84,99,"Severe oligoasthenoteratozoospermia"]
["Proband_105","Netherlands",36,"No",null,"No",null,"None","None",18,15,111,5,"NA",7.4,5.5,0.1,12,0.07,"ND","Severe oligoasthenozoospermia"]
["Proband_106","Netherlands",33,"Yes","Parents had difficulties with conceiving, 7 year age gap between patient and his brother. Mother had 2 miscarriages","No",null,"Inguinal hernia bilateral","None",20,15,24.3,12,"No:  testicular and epididymis cyst left",7.5,3.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_107","Netherlands",40,"No",null,"No",null,"None","None","Unknown","Unknown","NA",0,"NA",7.5,2.7,0.8,23,0.5,98,"Severe oligoasthenoteratozoospermia"]
["Proband_108","Netherlands",40,"Unknown",null,"Unknown",null,"Unknown","Did not receive a full consultation in Radboudumc","Unknown","Unknown","NA",0,"NA",7.5,3.2,0.5,14,0.22,98,"Severe oligoasthenoteratozoospermia"]
["Proband_109","Netherlands",31,"Unknown",null,"Unknown",null,"None","None",20,20,164,7,"Yes",7.5,3.9,0.1,9,0.04,98,"Severe oligoasthenoteratozoospermia"]
["Proband_110","Netherlands",32,"No",null,"No",null,"None","None",8,8,24,35.2,"Yes",7.2,9.1,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_111","Netherlands",32,"No",null,"No",null,"None","None",15,15,5,17.9,"NA",7.5,3.5,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_112","Netherlands",35,"Yes","Uncle with infertility and is childless","No",null,"None","None","Unknown","Unknown","ND","ND","Yes",7.2,5.2,0.4,51,1.1,99,"Severe oligoteratozoospermia"]
["Proband_113","Netherlands",41,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy; inguinal hernia bilateral","None",15,15,78,16,"No: microcalcifications left",7.2,5.6,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_114","Netherlands",33,"No",null,"No",null,"None","None","Unknown","Unknown","ND","ND","NA",7.7,3.9,4,2,0.31,98,"Severe oligoasthenoteratozoospermia"]
["Proband_115","Netherlands",35,"Yes","Uncle with male factor infertility (asthenozoospermia)","No",null,"None","Bof, unknown if orchitis",25,25,136,2.4,"NA",6.7,0.9,3.1,0,0,"ND","Severe oligoasthenozoospermia"]
["Proband_116","Netherlands",32,"Unknown",null,"Unknown",null,"None","None","Unknown","Unknown","ND","ND","NA",7.7,0.8,5,9,0.36,98,"Severe oligoasthenoteratozoospermia"]
["Proband_117","Netherlands",42,"Unknown",null,"Unknown",null,"Unknown","Did not receive a full consultation in Radboudumc","Unknown","Unknown","NA","Unknown","NA",7.2,8.2,0,"ND","ND","ND","Azoospermia","Unclear OA or NOA"]
["Proband_118","Netherlands",37,"No",null,"No",null,"None","None",15,15,15,15,"No: post-epididymitis right",7.5,5.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_119","Netherlands",36,"No",null,"No",null,"Varicocele unilateral","None","Unknown","Unknown","ND","ND","NA",7.5,3.4,2.5,17,1.4,99,"Severe oligoasthenoteratozoospermia"]
["Proband_120","Netherlands",44,"No",null,"No",null,"Unknown","None","Unknown","Unknown","NA","Unknown","NA",7.7,2.3,1.7,9,"ND","ND","Severe oligoasthenozoospermia"]
["Proband_121","Netherlands",44,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy","None",20,20,"NA",5.4,"No: varicocele left",7.6,3.5,0,"ND","ND","ND","Azoospermia","Unclear OA or NOA"]
["Proband_122","Netherlands",41,"No",null,"Unknown",null,"None","None",20,20,196,5,"No; varicocele left",7.5,5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_123","Netherlands",45,"No",null,"No",null,"None","None",10,15,"NA",7,"NA",7.8,4.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_124","Netherlands",44,"No",null,"No",null,"None","Previously 4x ICSI in Germany; no pregnancy","Unknown","Unknown","ND","ND","NA",7.5,3.5,2,12,0.84,99,"Severe oligoasthenoteratozoospermia"]
["Proband_125","Netherlands",38,"No",null,"No",null,"Cryptorchidism unilateral, conservative treatment","None",15,15,80,13,"Yes",7.5,2.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_126","Netherlands",39,"Unknown",null,"Unknown",null,"None","None",18,15,"ND",15,"NA",7.6,1.9,0.4,5,0.04,99,"Severe oligoasthenoteratozoospermia"]
["Proband_127","Netherlands",49,"No",null,"No",null,"None","None",20,20,150,8,"NA",7.4,1.8,"<0.1","ND","ND","ND","Extreme oligozoospermia"]
["Proband_128","Netherlands",28,"No",null,"Yes","Second cousin with Down's syndrome","Retractile testis as a child","None",6,6,43.5,16,"Yes",8,1.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_129","Netherlands",31,"Yes","Uncle from mothers side had fertility problems and no children","No",null,"Cryptorchism unilateral with orchidopexy, unilateral absence of testicle, atrophic kidney unilateral, inguinal hernia bilateral","None",6,"Absent",5,41.3,"Yes",7.2,3.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_130","Netherlands",34,"No",null,"Possible","Cousin with cleft palate","Epididymitis","None",15,12,52.3,9.4,"Yes",7.7,3.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_131","Netherlands",30,"No",null,"Yes","Cousin with intellectual disability","None","None",15,15,19.9,14,"Yes",8,3.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_132","Netherlands",33,"No",null,"No",null,"Testicular trauma","None",10,10,5,21,"Yes",7.7,5.4,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_133","Netherlands",30,"No",null,"No",null,"Testicular trauma bilateral","None",15,15,225,5,"Yes",7.5,1.7,0,"ND","ND","ND","Azoospermia","Unclear OA or NOA"]
["Proband_134","Netherlands",27,"No",null,"No",null,"None","None",12,10,18.9,17.5,"No: varicocele left",8,1.2,0,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_135","Netherlands",31,"No",null,"No",null,"None","Attention-deficit hyperactivity disorder (ADHD)",6,6,"<10",19,"Yes",7.7,2.2,"<0.1",50,"ND","ND","Severe oligozoospermia"]
["Proband_136","Netherlands",39,"No",null,"No",null,"None","None",10,15,92.5,3.3,"No: varicocele bilateral",7.7,5.3,0.4,28,0.6,"ND","Severe oligoasthenozoospermia"]
["Proband_137","Netherlands",32,"No",null,"No",null,"None","None",12,12,82.5,5.8,"Yes",7.8,0.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_138","Netherlands",35,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy; inguinal hernia bilateral; excision of cyste in left testicle","None",6,12,48.6,13,"No: cyst left",7.5,4.2,0.1,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_139","Netherlands",32,"No",null,"No",null,"Cryptorchism bilateral with orchidopexy","None",5,5,46.6,12,"No: varicocele bilateral, cyst left",7.9,3,0,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_140","Netherlands",39,"No",null,"No",null,"None","Gynaecomastia",12,12,14.9,16,"No: hydrocele bilateral",7.5,3.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_141","Netherlands",34,"No",null,"No",null,"None","None",10,10,37.4,26,"No: inhomogenous lesion bilateral",7.2,2.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_142","Netherlands",28,"No",null,"No",null,"None","None",10,10,39.7,15,"Yes",7.2,3.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_143","Netherlands",31,"Yes","Father had male factor infertility","No",null,"None","Migraine",15,15,"NA",22,"No: cyst right",7.5,3.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_144","Unknown",31,"No",null,"No",null,"None","None",8,8,"ND",14.2,"No: varicocele left",7.5,4.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_145","Netherlands",38,"Yes","Sisters received hormonal treatment due to infertility, she now has 3 children","No",null,"None","None",12,12,"NA",4,"Yes",7.7,3.2,0.01,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_146","Unknown",33,"No",null,"No",null,"None","None",10,10,"ND",9.7,"No: varicocele left, epididymis cyst bilateral",7.7,6.7,0.6,30,1.206,"ND","Severe oligoasthenozoospermia"]
["Proband_147","Netherlands",30,"No",null,"Yes"," Congenital cardiomyopathie ","None","None",15,12,"NA",17,"Yes",7.7,4.3,0.01,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_148","Netherlands",31,"No",null,"No",null,"None","None",8,8,"NA",11,"No: varicocele left",8,0.6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_149","Netherlands",34,"No",null,"No",null,"None","None",8,8,"NA",26,"Yes",7.5,3.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_150","Netherlands",38,"No",null,"No",null,"None","Cystoscopy without abnormalities (symptoms of pain)",8,8,"NA",26,"Yes",7.7,4.1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_151","Netherlands",37,"Yes","No infertility but a brother and cousin with cryptorchidism","No",null,"Cryptorchidism bilateral with orchidopexy ","None",10,6,"ND",20,"No: varicocele left",8,2.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_152","United Arab Emirates",36,"Yes","Youngest brother with male factor infertility (azoospermia)","No",null,"None","None",10,10,"ND",4.8,"No: hydrocele left, cyst right",8,2.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_153","Netherlands",29,"Yes","Brother is known with male factor infertility, conceived after insemination treatment","No",null,"None","None",10,10,"ND",27,"Yes",7.2,2.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_154","Netherlands",30,"No",null,"No",null,"None","None",16,16,"NA",2,"No: microcalcifications right",7.7,12.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_155","Netherlands",27,"Yes","Uncle with fertility problems, unknown cause","No",null,"None","None",12,10,"NA",11,"No: hydrocele bilateral",7.7,6.1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_156","Netherlands",45,"No",null,"No",null,"None","None",10,12,"NA",19,"No: microcalcifications right",7.5,2.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_157","Netherlands",35,"No",null,"No",null,"Inguinal hernia unilateral","None",5,6,"NA",28,"No: varicocele left, cyst right",8,1.6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_158","Netherlands",26,"No",null,"No",null,"None","None",15,15,"NA",5,"Yes",7.7,2.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_159","Netherlands",27,"No",null,"No",null,"Cryptorchism bilateral with orchidopexy","None",5,5,"NA",33,"No: cyst left, hypovascularisation right",7.7,4.3,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_160","Netherlands",32,"Yes","Cousin with male factor infertility (oligozoospermia)","No",null,"Inguinal hernia unilateral","None",15,10,"NA",10,"Yes",7.5,2.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_161","Netherlands",32,"Yes","Two sisters, both with irregulair menstrual cycle","No",null,"None","None",8,10,"NA",16,"No: varicocele left",7.5,6.1,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_162","Netherlands",34,"Yes","Brother fertility problems and cryptorchism","No",null,"Cryptorchism unilateral with orchidopexy","None",10,20,"NA",8.3,"No: hydrocele right",7.5,2.1,0.1,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_163","Netherlands",37,"No",null,"No",null,"None","None",8,6,"NA",13,"No: microcalcifications left, epididymis cyst right",7.5,3.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_164","Netherlands",37,"No",null,"No",null,"None","Patent ductus arteriosus",6,6,"NA",19,"No: microcalcifications left",7.7,1.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_165","Netherlands",35,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy; orchidectomy unilateral due to torsio","None",null,10,"NA",23,"Yes",7.9,4.4,0,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_166","Netherlands",30,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy; intra-abdominal gonade unilateral; hypoplastic prostate; mullerian duct remnants; disorders of sexual development (DSD)","None",3,"Unknown","NA",33,"No: atrophic testis left",7.5,2.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_167","Netherlands",33,"No",null,"No",null,"None","None",15,15,"NA",2.7,"No: microcalcifications bilateral",7.5,2.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_168","Netherlands",37,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy","None",6,10,"NA",10,"Yes",7.5,3.6,0,"ND","ND","ND","Extreme oligozoospermia"]
["Proband_169","Netherlands",34,"No",null,"No",null,"Correction of hypospadia","None",12,8,"NA",18.3,"No: cyst left",7.7,4,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_170","Netherlands",43,"No",null,"No",null,"Cryptorchism unilateral; inguinal hernia unilateral","Colitis ulcerosa",10,10,"NA",33,"Yes",7.7,2.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_171","United Kingdom",27,"No",null,"No",null,"None","Right ear surgery - deaf",15,15,"NA",7.4,"NA",8,2.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_172","United Kingdom",36,"No",null,"No",null,"None","Cholecystectomy and gastric bypass (2011)",15,15,"NA",11.3,"NA",8,9.9,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_173","United Kingdom",30,"No",null,"No",null,"None","Asthma",20,20,"NA",18.4,"NA",7.5,2.6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_174","United Kingdom",32,"Yes","Cousin has CF ","No",null,"Left varicocele embolisation","Right strangulated hernia as a baby;",20,20,"NA",20.8,"NA",8,4.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_175","United Kingdom",35,"No",null,"No",null,"Cryptorchism bilateral with orchidopexy; Seminoma","Anxiety/depression;",8,8,"NA",49.2,"NA",8.5,3.2,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_176","United Kingdom",34,"No",null,"No",null,"Varicocele","None",15,15,"NA",19.3,"NA",7.5,3.6,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_177","United Kingdom",23,"No",null,"No",null,"None","None",8,6,"NA",11.4,"NA","Unknown",5.2,"<2",49,5.1,99,"Severe oligozoospermia"]
["Proband_178","United Kingdom",33,"No",null,"No",null,"Cryptorchism bilateral with orchidopexy","Undescended Testes",10,12,"NA",19,"NA","Unknown",4.3,"<2",30,0.6,100,"Severe oligozoospermia"]
["Proband_179","United Kingdom",31,"Yes","Brother x2 required ICSI treatment for very poor sperm quality. Paternal Uncle and Aunt are infertile as well.","No",null,"Cryptorchism bilateral with orchidopexy","Gastic reflux",12,12,"NA",28.4,"NA",8,3.5,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_180","United Kingdom",40,"No",null,"No",null,"Cryptorchism bilateral with orchidopexy","RTA fractured pelvis",10,10,"NA",25.8,"NA",8,6.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_181","United Kingdom",38,"No",null,"No",null,"Cryptorchism unilateral with orchidopexy","None",30,30,"NA",5.4,"NA","Unknown",7.1,"<2",20,2.8,99,"Severe oligozoospermia"]
["Proband_182","United Kingdom",30,"No",null,"No",null,"Cryptorchism bilateral with orchidopexy","None",15,15,"NA",36.2,"NA",8,3.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_183","United Kingdom",38,"No",null,"No",null,"Cryptorchism","Gout",15,15,"NA",16,"NA",10,4.7,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_184","United Kingdom",30,"No",null,"No",null,"Small R+L varicoceles","Asthma; Lesion at cervicomedullary junction = asymptomatic; Peanut allergy",25,25,"NA",20,"NA","Unknown",2.8,0,"ND","ND","ND","Azoospermia","NOA"]
["Proband_185","United Kingdom",31,"No",null,"No",null,"None","None",10,10,"NA",21.2,"NA",9,2.4,0,"ND","ND","ND","Azoospermia","NOA"]
[]
["NA =not available"]
["ND = not determined"]
["NOA = non-obstructive azoospermia"]
["* At diagnosis of infertility"]

{"sheet":"Table 2 Treatment outcome","index":1,"n_rows":117,"n_cols":9,"rows_kept":117}
["ID","TESE performed","TESE side","Sperm found","Sperm motility","TESE Malignancy","ICSI treatment ","Pregnancy","Live birth"]
["Proband_001","Yes","Left","No","No sperm","No","No","No","No"]
["Proband_002","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_003","Yes","Both","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_004","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_005","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_006","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_007","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_008","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_009","Yes","Left","No","No sperm","No","No","No","No"]
["Proband_010","Yes","Left","No","No sperm","No","No","No","No"]
["Proband_011","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_012","Yes","Right","Yes","Non-motile","No","Yes","Yes","Yes"]
["Proband_013","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_014","Yes","Right","No","No sperm","No","No","No","No"]
["Proband_015","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_016","Yes","Right","No","No sperm","No","No","No","No"]
["Proband_017","Yes","Both, sperm both sides","Yes","Motile","No","Yes","No","No"]
["Proband_018","Yes","Left","Yes","Non-motile","No","Yes","No","No"]
["Proband_019","Yes","Left","No","No sperm","No","No","No","No"]
["Proband_020","Yes","Right","Yes","Motile","Unknown","Yes","Yes","Yes"]
["Proband_021","Yes","Left","No","No sperm","No","No","No","No"]
["Proband_022","Yes","Right","No","No sperm","Unknown","No","No","No"]
["Proband_023","Yes","Left","Yes","Motile","No","Yes","No","No"]
["Proband_024","Yes","Right","Yes","Motile","Unknown","Yes","No","No"]
["Proband_025","Yes","Both, sperm right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_026","Yes","Right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_027","Yes","Left","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_028","Yes","Both, sperm right","Yes","Non-motile","No","Yes","No","No"]
["Proband_029","Yes","Right","No","No sperm","No","No","No","No"]
["Proband_030","Yes","Left","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_031","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_032","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_033","Yes","Right","No","No sperm","Unknown","No","No","No"]
["Proband_034","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_035","Yes","Both, sperm right","Yes","Motile","No","Yes","No","No"]
["Proband_036","Yes","Left","No","No sperm","No","No","No","No"]
["Proband_037","Yes","Right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_038","Yes","Unknown","Unknown","Unknown","Unknown","Yes","Yes","Yes"]
["Proband_039","Yes","Both, sperm right","Yes","Non-motile","No","No","No","No"]
["Proband_040","Yes","Right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_042","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_043","Yes","Left","Yes","Non-motile","No","Yes","No","No"]
["Proband_044","Yes","Left","No","No sperm","No","No","No","No"]
["Proband_045","Yes","Right","No","No sperm","Unknown","No","No","No"]
["Proband_046","Yes","Both, sperm right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_047","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_048","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_053","Yes","Right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_059","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_060","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_061","Yes","Both, sperm right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_063","Yes","Both, sperm right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_065","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_069","Yes","Right","Yes","Motile","No","Yes","No","No"]
["Proband_070","Yes","Both","Yes","Motile","No","No","No","No"]
["Proband_077","Yes","Left","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_079","Yes","Right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_083","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_086","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_089","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_090","Yes","Unknown","Yes","Motile","Unknown","Yes","Yes","Yes"]
["Proband_092","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_095","Yes","Right","Yes","Motile","Unknown","Yes","Yes","Yes"]
["Proband_096","Yes","Both, sperm both sides","Yes","Non-motile","No","Yes","Yes","Yes"]
["Proband_097","Yes","Left","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_106","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_115","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_121","Yes","Right","Yes","Non-motile","No","Yes","No","No"]
["Proband_122","Yes","Right","Yes","Unknown","No","Yes, zero oocytes","No","No"]
["Proband_123","Yes","Unknown","Yes","Non-motile","No","Yes","No","No"]
["Proband_125","Yes, elsewhere","Unknown, elsewhere","Unknown","Unknown, elsewhere","Unknown, elsewhere","Yes, elsewhere","Yes","Yes"]
["Proband_128","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","No"]
["Proband_129","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_131","Yes","Both, sperm left","Yes","Non-motile","No","Yes","Yes","Yes"]
["Proband_132","Yes","Both, sperm both sides","Yes","Non-motile","No","Yes","Yes","Yes"]
["Proband_134","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_137","Yes","Both, sperm right","Yes","Motile","No","Yes","No","No"]
["Proband_138","Yes","Right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_140","Yes","Both, sperm both sides","Yes","Motile","No","Yes","No","No"]
["Proband_141","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_142","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","No"]
["Proband_143","Yes","Both, sperm both sides","Yes","Motile","No","Yes","No","No"]
["Proband_144","Yes","Both, sperm both sides","Yes","Motile","Unknown","Yes","Yes","Yes"]
["Proband_148","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_149","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_150","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_151","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_152","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_153","Yes","Both, sperm right","No","Motile","No","Yes","Yes","Yes"]
["Proband_155","Yes","Both, sperm right","Yes","Motile","No","Yes","No","No"]
["Proband_156","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_157","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_159","Yes","Both, sperm right","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_160","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_161","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_162","Yes","Right, no sperm","No","No sperm","No","No","No","No"]
["Proband_163","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_164","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_165","Yes","Right","Yes","Non-motile","No","Yes","Yes","Yes"]
["Proband_166","Yes","Both, no sperm","No","No sperm","No","No","No","No"]
["Proband_167","Yes","Both, sperm both sides","Yes","Motile","No","Yes","Yes","Yes"]
["Proband_168","Yes","Both, sperm both sides","Yes","Motile","No","Yes","No","No"]
["Proband_169","Yes","Both, sperm both sides","Yes","Motile","No","Yes","No","No"]
["Proband_170","Yes","Both, sperm both sides","Yes","Motile","No","No","No","No"]
["Proband_171","Yes","Both, no sperm","No","No sperm","Unknown","No","No","No"]
["Proband_172","Yes","Both, sperm both sides","No","Non-motile","Unknown","No","No","No"]
["Proband_173","Yes","Both, sperm right","Yes","Motile","Unknown","Yes","Unknown","Unknown"]
["Proband_174","Yes","Right, no sperm","No","No sperm","Unknown","No","No","No"]
["Proband_175","Yes","Left","Yes","Motile","Unknown","Yes","Yes","No, miscarriage"]
["Proband_176","Yes","Both, sperm both sides","Yes","Non-motile","Unknown","Yes","No","No"]
["Proband_179","Yes","Both","Yes","Motile","Unknown","Yes","No","No"]
["Proband_180","Yes","Both, sperm right","Yes","Non-motile","Unknown","No","No","No"]
["Proband_182","Yes","Both","Yes","Non-motile","Unknown","No","No","No"]
["Proband_183","Yes","Both, no sperm","No","No sperm","Unknown","No","No","No"]
["Proband_184","Yes","Both, no sperm","No","No sperm","Unknown","No","No","No"]
["Proband_185","Yes","Both, no sperm","No","No sperm","Unknown","No","No","No"]

{"sheet":" Table 3 Histology classificati","index":2,"n_rows":13,"n_cols":2,"rows_kept":13,"merged":[[4,1,7,1],[8,1,10,1]]}
["Classification","Definition"]
["Tubular shadow (TS)","The complete absence of Sertoli and germ cells in the seminiferous epithelium."]
["Sertoli cell only (SCO)","Only Sertoli cells are present in tubules. Germ cells are completely absent."]
["SCO/minimal-Germ Cell Arrest(mCGCA)","Predominantly tubules in which only Sertoli cells are present. In addition, some tubules that do contain germ cells are observed. These germ cells are arrested prior to finalization of spermatogenesis."]
["Germ Cell Arrest (GCA)","Spermatogenesis is blocked at a certain stage prior to its finalization."]
["GCA in spermatogonia"]
["GCA in meiosis"]
["GCA in spermiogenesis"]
["Hypospermatogenesis (HS)","Tubules that only contain Sertoli cells are present in addition to tubules that contain all stages of spermatogenesis."]
["HS-mild"]
["HS-severe"]
["HS-partial Germ Cell Arrest","Tubules that show normal, unperturbed spermatogenesis are present, in addition to tubules that show a germ cell arrest."]
["Complete Spermatogenesis (CS)","The majority of tubules contains all stages of spermatogenesis."]

{"sheet":"Table 4 Pathology notes","index":3,"n_rows":118,"n_cols":12,"rows_kept":118}
["ID","Conclusion histology left","Conclusion histology right","Overall conclusion histology","Conclusion cytology left","Conclusion cytology right","Overall conclusion cytology","Spermatozoa in cell suspension biopsy","Diagnosis semen analysis ","Description of spermatogenesis in proband","Overall conclusion","Detailed conclusion"]
["Proband_001","HS-severe","NP","HS-severe","HS","NP","HS","No","Azoospermia","Both histological sections and cytological preparations indicated hypospermatogenesis. Predominantly (~95%) tubules containing Sertoli cells only were present, occasionally tubules did contain complete spermatogenesis. ","HS","HS-severe"]
["Proband_002","SCO","SCO","SCO","SCO/minimal GCA","SCO/minimal GCA","SCO/minimal GCA","No","Azoospermia","No tubules containing germ cells were observed in the histological sections. However a small number of spermatocytes were observed in the cytological preparations. No spermatozoa were observed in any of the three types of testicular preparations.","SCO/minimal GCA","SCO/minimal GCA"]
["Proband_003","HS-severe","HS-mild","HS-mild","SCO","CS","SCO/CS","Yes","Extreme oligozoospermia","Both biopsies used for histology showed a reduced level of spermatogenesis and extensive hyalinization. In the left biopsy only ~10% of the tubules showed elongating spermatids whereas on the right side this was ~30%. ","HS","HS-mild"]
["Proband_004","SCO","SCO","SCO","SCO","SCO","SCO","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_005","SCO","SCO","SCO","SCO","SCO","SCO","No","Azoospermia","No germ cells were observed in any of the three types of testicular preparations. ","SCO","SCO"]
["Proband_006","GCA in meiosis","GCA in meiosis","GCA in meiosis","SCO/minimal GCA","SCO/minimal GCA","SCO/minimal GCA","No","Azoospermia","Histology preparations showed a complete maturation arrest at the spermatocyte stage. The number of germ cells with respect to Sertoli cells was decreased according to cytology, though histological sections did not indicate tubules completely devoid of germ cells.","GCA","GCA-meiosis"]
["Proband_007","SCO","SCO","SCO","SCO","NA","SCO","No","Azoospermia","No germ cells were observed in  any of the three types of testicular preparations. Cytological preparation of one biopsy was unavailable.","SCO","SCO"]
["Proband_008","SCO","SCO","SCO","SCO","SCO","SCO","No","Azoospermia","No germ cells were observed in  any of the three types of testicular preparations.","SCO","SCO"]
["Proband_009","SCO","NP","SCO","SCO","NP","SCO","no","Azoospermia","A complete lack of germ cells was observed in this biopsy while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_010","SCO","NP","SCO","NA","NP","-","No","Azoospermia","No germ cells were observed in histological preparations nor in the biopsy-derived cell suspension. Cytological preparations were unavailable.","SCO","SCO"]
["Proband_011","SCO","SCO","SCO","SCO","SCO","SCO","no","Azoospermia","A complete lack of germ cells was observed in both biopies while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_012","NP","CS","CS","NP","pGCA","pGCA","Yes","Extreme oligozoospermia","Histological sections showed that 75% of the tubules contained ES. Frequently germ cell devoid patches in the epithelium were observed. The cytological analysis indicated a partial maturation arrest.  ","CS","CS"]
["Proband_013","SCO","SCO","SCO","SCO","SCO","SCO","No","Azoospermia","No germ cells were observed in any of the three types of testicular preparations. ","SCO","SCO"]
["Proband_014","NP","SCO","SCO","NP","SCO","SCO","No","Azoospermia","No germ cells were observed in any of the three types of testicular preparations. ","SCO","SCO"]
["Proband_015","SCO","SCO","SCO","SCO","SCO","SCO","No","Azoospermia","No germ cells were observed in any of the three types of testicular preparations. ","SCO","SCO"]
["Proband_016","NP","SCO","SCO","NP","SCO","SCO","no","Azoospermia","A complete lack of germ cells was observed in this biopsy while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_017","HS-severe","NA","HS-severe","HS + pGCA","NA","HS + pGCA","Yes","Azoospermia","Only a crushed biopsy from the left testis was available for analysis. In these histological sections a mix of tubules devoid of germ cells (~90%) and tubules containing complete spermatogenesis was observed. Cytological analysis also indicated a starkly decreased number of germ cells (spermatocytes and spermatozoa) in respect to Sertoli cells, which fits with the observed HS in histological sections. In addition the spermatocyte/spermatozoa ratio was suggestive for a partial maturation arrest.  ","HS","HS-severe"]
["Proband_018","HS-severe","NP","HS-severe + tubular hyalinization ","SCO/minimal GCA","NP","SCO/minimal GCA","Yes","Extreme oligozoospermia","Limited power of histological analysis due to poor structural conservation of biopsy. Some germ cells were observed in histological sections and cytological preparations. Spermatozoa were present in the cell suspension.","HS","HS-severe"]
["Proband_019","SCO","NP","SCO","SCO","NP","SCO","No","Azoospermia","Quality of histological sections was poor due to crushing of biopsy. No germ cells were observed in any of the three types of testicular preparations. ","SCO","SCO"]
["Proband_020","NP","NA","-","NP","SCO","SCO","Yes","Azoospermia","No biopsy was availbale for histological analysis. The cytological preparation showed presence of only Sertoli cells suggesting SCO. However, some spermatozoa were seen during inspection of the biopsy-derived cell suspension though, indicative of hypospermatogenesis.","HS","HS-severe"]
["Proband_021","SCO","NP","SCO","SCO","NP","SCO","No","Azoospermia","No germ cells were observed in testicular preparations or in the biopsy-derived cell suspension.","SCO","SCO"]
["Proband_022","NP","NA","-","NP","SCO","SCO","No","Azoospermia","No biopsy was availbale for histological evaluation. Germ cells were absent from the cytological preparation and the biopsy-derived cell suspension.","SCO","SCO"]
["Proband_023","HS-severe","NP","HS-severe","NA","NP","-","Yes","Azoospermia","Apart from numerous (~90%) tubules devoid of any germ cells, some tubules containing complete or incomplete spermatogenesis were also observed. When arrest occurred this was in spermatocytes. Cytological preparations were unavailable.","HS","HS-severe"]
["Proband_024","NA","NA","-","HS","NA","HS","Yes","Azoospermia","Histological sections were not available. Spermatozoa and meiotic cells were observed in the cytological preparation though both their numbers were low.","HS","HS-severe"]
["Proband_025","HS-severe","SCO","HS-severe","SCO/minimal GCA","SCO","SCO/minimal GCA","Yes","Azoospermia","Only histological sections of crushed biopsies available. The left biopsy predominantly (~95%) showed germ cell-devoid tubules. However, pockets of tubules containing complete spermatogenesis were observed. In the sections from the right bipsy no germ cells were observed. In the cytological preparation of the left biopsy a small number of spermatocytes was observed, though no spermatozoa. Spermatozoa were observed in the cell suspension. In the cytological preparation of the 2nd testicle no germ cells were observed.","HS","HS-severe"]
["Proband_026","NP","HS-pGCA","HS-pGCA","NP","HS","HS","Yes","Azoospermia","Histological evaluation showed both tubules with complete spermatogenesis (45%) as well as tubules in which meiotic cells and spermatids were absent. The cytological evaluation indicated a loss of germ cells in relation to Sertoli cells.  ","HS","HS-pGCA"]
["Proband_027","HS-pGCA","NP","HS-pGCA","pGCA","NP","pGCA","Yes","Azoospermia","Histological examination indicated that ~45% of the tubules contained complete spermatogenesis. However several tubules showed an absence of spermatids. Patches without germ cells were frequently present in the epithelium. Spermatocyte-spermatozoa ratio in the cytological prepartion was also indicative for a partial maturation arrest.","HS","HS-pGCA"]
["Proband_028","GCA-spermatogonia","GCA-spermatogonia","GCA-spermatogonia","SCO/minimal GCA","SCO/minimal GCA","SCO/minimal GCA","yes","Extreme oligozoospermia","Extensive hyalinization was observed in both biopsies. In all tubules germ cells were present but in most of them only as spermatogonia. Infrequently some spermatocytes but no spermatids were observed. This was confirmed by cytology. In the TESE sample analysed for cryopreservation, however, spermatozoa were observed.","HS","HS-severe"]
["Proband_029","NP","SCO","SCO","NP","SCO/minimal GCA","SCO/minimal GCA","No","Azoospermia","None of the tubules observed in the histological sections contained germ cells. However, a small number of spermatocytes was observed in the cytological preparations. No spermatozoa were detected in any of the three types of testicular preparations.","SCO/minimal GCA","SCO/minimal GCA"]
["Proband_030","HS","NP","HS-mild","CS","NP","CS","yes","Extreme oligozoospermia","Only testis scrapes were available for analysis. Disorted tubules with and without content were observed. Cytology indicated complete spermatogenesis.","HS","HS-mild"]
["Proband_031","SCO","SCO","SCO","SCO/minimal GCA","NA","SCO/minimal GCA","yes","Azoospermia","Only testis scrapes were available for analysis. No germ cells were observed in the distorted tubules while in the cytology sample some spermatocytes were observed. In the TESE sample analysed for cryopreservation, however, spermatozoa were observed.","HS","HS-severe"]
["Proband_032","SCO/minimal GCA","CS","CS","HS","CS","CS","Yes","Azoospermia","Status of spermatogenesis varied greatly between the two testes. The right biopsy consisted mainly (~75%) of tubules that contained ES whereas in the biopsy of the left side, predominantly germ cell-devoid tubules, sometimes with spermatogonia and less frequently with spermatocytes were observed. The cytological preparation confirmed complete spermatogenesis in the right biopsy. In cytological slide of the left biopsy one spermatozoa was detected, indicating HS instead of GCA.","CS","CS"]
["Proband_033","NP","NA","-","NP","SCO","SCO","No","Azoospermia","Histology preparations were unavailable. No germ cells were observed in testicular preparation (based on cytology only) or in the biopsy-derived cell suspension.","SCO","SCO"]
["Proband_034","SCO","NA","SCO","SCO","SCO","SCO","No","Azoospermia","No germ cells were observed in any of the three types of testicular preparations. Histological sections of the right biopsy were absent.","SCO","SCO"]
["Proband_035","HS-pGCA","NA","HS-pGCA + tubular hyalinization","HS","NA","HS","Yes","Azoospermia","Only one testis biopsy was available for analysis. Histological sections showed extensive hyalinization of the tubules. A mix of tubules devoid of germ cells and tubules containing complete or incomplete spermatogenesis was observed. When the germ cell population was arrested this was during meiosis. Cytological analysis indicated a starkly decreased number of germ cells in respect to Sertoli cells. Number of spermatocytes and spermatozoa were too low to distinguish HS from pGCA.","HS","HS-pGCA"]
["Proband_036","SCO","NP","SCO","SCO","NP","SCO","no","Azoospermia","A complete lack of germ cells was observed in this biopsy while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_037","NP","HS-pGCA","HS-pGCA","NP","pGCA","pGCA","Yes","Azoospermia","Frequently tubules that show meiotic arrest in addition to tubules with complete spermatogenesis were observed in the histological sections. The cytological data also indicated a p-MA.","HS","HS-pGCA"]
["Proband_038","NA","NP","-","HS","NP","HS","Yes","Azoospermia","No biopsy was available for histological analysis. The cytological preparation predominantly showed Sertoli cells, though a small number of spermatocytes and one spermatozoa were observed.","HS","HS-severe"]
["Proband_039","SCO","SCO","SCO","SCO","NA","SCO","Yes","Azoospermia","No germ cells were observed in either histological or cytological preparations.  However, some spermatozoa were seen during inspection of the biopsy-derived cell suspension, though indicative of hypospermatogenesis.","HS","HS-severe"]
["Proband_040","NP","NA","-","NP","HS + pGCA","HS","yes","Azoospermia","No histology sample was available. In the cytology sample spermatoza were observed to such an extend that suggested HS-mild. This was also the case in the biopsy analysed for cryopreservation.","HS","HS-mild"]
["Proband_041","HS-severe","NP","HS-severe","HS + pGCA","NP","HS + pGCA","yes","Azoospermia","The biopsy was damaged during processing. In some tubules germ cells are present and in a subset of these as elongating spermatids. Predominantly tubules with only Sertoli cells were present. In addition, extensive hyalinization was noted. A limited number of spermatozoa was observed in the cytology preparation.","HS","HS-severe"]
["Proband_042","SCO + hyalinization","SCO + hyalinization","SCO + hyalinization","SCO","SCO","SCO","No","Azoospermia","No germ cells were observed in any of the three types of testicular preparations. ","SCO","SCO"]
["Proband_043","NA","NP","-","HS + pGCA","NP","HS + pGCA","yes","Azoospermia","No histology sample was available. In the cytology sample spermatoza were observed to such an extend that suggested HS-severe. This was also the case in the biopsy analysed for cryopreservation.","HS","HS-severe"]
["Proband_044","NA","NP","-","HS","NP","HS","no","Azoospermia","No histology sample was available. In the cytology sample spermatoza were observed to such an extend that suggested HS-severe. In the biopsy analysed for cryopreservation no spermatozoa were detected.","HS","HS-severe"]
["Proband_045","NP","NA","-","NP","SCO","SCO","No","Azoospermia","Only the cytological preparation was available, herein no germ cells were observed. During inspection of the biopsy-derived cell suspension no spermatozoa were observed either.","SCO","SCO"]
["Proband_046","NA","CS","CS","SCO/minimal GCA","CS","CS","Yes","Azoospermia","No histological sections of left testes available. Quality of histological sections of right side was low due to crushing of the biopsy. In this biopsy 80% of the tubules contained ES. In addition, also tubules in which germ cells were absent were observed. This was confirmed by the cytological preparation. In the cytological preparation of the left bipsy only a small number of spermatocytes were observed.","CS","CS"]
["Proband_047","SCO","SCO","SCO","SCO","SCO","SCO","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_048","HS-pGCA","GCA","HS-pGCA","HS","HS","HS","No","Extreme oligozoospermia","Predominantly germ cell devoid-tubules were observed in the histological sections. Pockets of tubules containing complete or incomplete spermatogenesis were observed in the left biopsy. Only arrested spermatogenesis was observed in the right biopsy. The arrest of spermatogenesis was predominantly occuring prior to meiosis. The number of spermatocytes and spermatozoa counted in the cytological preparations were too low to distinguish HS from p-MA.","HS","HS-pGCA"]
["Proband_053","NP","HS-severe","HS-severe","NP","HS-pGCA","HS-pGCA","Yes","Extreme oligozoospermia","Histological sections showed ~95% of tubules to contain only Sertoli cells. Occasionally, the epithelium did contain the complete germ cell compartment. The spermatocyte-spermatozoa ratio in the cytological preparations indicated a mild partial arrest and reduced number of spermatozoa per Sertoli cell.","HS","HS-severe"]
["Proband_059","SCO","SCO","SCO","SCO","SCO","SCO","No","Azoospermia","No germ cells were observed in any of the three types of testicular preparations. ","SCO","SCO"]
["Proband_060","GCA-spermiogenesis","GCA-spermiogenesis","GCA-spermiogenesis","NA","NA","-","No","Azoospermia","Cytological preparations were absent. Histological sections consistantly showed an arrest prior to spermatid elongation.","GCA","GCA-spermiogenesis"]
["Proband_061","SCO/minimal GCA","HS-pGCA","HS-pGCA","NA","NA","-","Yes","Azoospermia","Cytological preparations were absent. In the histological sections tubules devoid of germ cells were observed in both biopsies although not in equal degree. In the right side biopsy, tubules with complete spermatogenesis and tubules with a maturation arrest predominantly in early meiosis were obsered whereas the left side biopsy showed predominantly Sertoli cell only tubules and occasionally tubules with spermatogenesis arrested in meiosis.","HS","HS-pGCA"]
["Proband_063","HS-severe","HS-severe","HS-severe","SCO","HS","HS","Yes","Extreme oligozoospermia","Histological sections showed frequent presence of tubules that contained only Sertoli cells (>95%). However, patches of complete spermatogenesis  were occasionally observed.","HS","HS-severe"]
["Proband_065","HS-pGCA","HS-pGCA","HS-pGCA","SCO","SCO","SCO","Yes","Azoospermia","In histological sections tubules the germ cell population consisted predominantly of spermatogonia or very early meiotic cells. However, in both biopsies 1-2 tubules with signs of complete spermatogenesis were seen. No spermatocytes or spermatozoa were seen in the cytology preparations. The biopsy-derived cell suspension, however, contained spermatozoa. ","HS","HS-pGCA"]
["Proband_069","NA","NA","-","NA","NA","-","yes","Extreme oligozoospermia","No histology or cytology samples were available. The TESE biopsy contained enough spermatozoa for the ICSI procedure but not enough for cryopreservation. Based on this the sample was classified as HS-severe.","HS","HS-severe"]
["Proband_070","HS-severe","CS","CS","NA","NA","-","Yes","Azoospermia","The left biopsy showed many hyalinzed tubules. In tubules with active spermatogenesis the density of cells was greatly reduced. The right-side biopsy predominantly contained tubules that showed normal spermatogenesis. However, frequently a reduced density of cells was in the epithelium was observed. Number of cells on the cytology slides was too low for quantification","CS","CS"]
["Proband_077","HS-mild","NP","HS-mild","HS + pGCA","NP","HS + pGCA","yes","Extreme oligozoospermia","Less than 30 tubules are available for analysis. Several of these show all stages of germ cells while other tubules only contain Sertoli cells. The cytology preparation indicated presence of all stages of germ cells. ","HS","HS-mild"]
["Proband_079","NP","HS-mild","HS-mild","NP","SCO/minimal GCA","SCO/minimal GCA","Yes","Azoospermia","Around 40% of the tubules contained complete spermatogenesis while  the remaining ones showed a lack of germ cells. The cytological preparation indicated an extremely reduced germ cell number with respect to Sertoli cells. ","HS","HS-mild"]
["Proband_083","CS","CS","CS","p-GCA","p-GCA","p-GCA","Yes","Azoospermia","In the histological sections 75% of the tubules contained ES. However, patches in the seminiferous epithelium with reduced numbers of germ cells were also observed. The cytological analysis indicated a loss of spermatozoa numbers.","CS","CS"]
["Proband_086","HS-pGCA","HS-pGCA","HS-pGCA","HS + pGCA","HS + pGCA","HS + pGCA","yes","Azoospermia","Histology showed severly thinned epithelium in both biopsies. All types of germ cells were present, though tubules showing spermatocytes and spermatids were starkly reduced. The arrest phenotype was also observed in the cytology preparations.","HS","HS-pGCA"]
["Proband_089","SCO/minimal GCA","SCO/minimal GCA","SCO/minimal GCA","SCO","SCO/minimal GCA","SCO/minimal GCA","no","Azoospermia","In both biopsies most tubules only contained Sertoli cells. Some tubules, however contained spermatogonia though spermatocytes were not observed. In the cytology preparation of the right side some spermatocytes were detected. A striking increased width of the basal lamine in many tubules was noted.","SCO/minimal GCA","SCO/minimal GCA"]
["Proband_090","NA","NA","-","NA","NA","-","Yes","Extreme oligozoospermia","No biopsy for histology was taken and no cytological slides were made. Spermatozoa were observed in the biopsy-derived cell suspension.","Unknown","Unknown"]
["Proband_092","SCO","SCO","SCO","SCO","SCO","SCO","No","Azoospermia","No germ cells were observed in any of the three types of testicular preparations. ","SCO","SCO"]
["Proband_095","NP","NA","-","NP","pGCA","pGCA","Yes","Azoospermia","No biopsy was availbale for histological analysis. The cytological preparation showed a normal ratio of spermatozoa and Sertoli cells but the spermatocyte/spermatozoa ratio was suggestive for a mild partial maturation arrest.","HS","HS-pGCA"]
["Proband_096","HS-pGCA","HS-pGCA","HS-pGCA","HS","HS","HS","Yes","Extreme oligozoospermia","Histological evaluation showed that the majority of the tubules were arrested the spermatocyte state.  Some tubules, however, did contain complete spermatogenesis. Cytological evaluation indicated a loss of germ cells in respect to Sertoli cells. Germ cells number were too low to distinguish p-MA from HS.","HS","HS-pGCA"]
["Proband_097","CS","NP","CS","CS","NP","CS","yes","Azoospermia","Most tubules contain elongating spermatids. Several tubules show a thinned epitithelium. This was confirmed by the cytology preparations.","CS","CS"]
["Proband_106","SCO","SCO","SCO","NA","NA","-","No","Azoospermia","All observed tubules in both biopsies were devoid of germ cells, also in the biopsy-derived cell suspension no spermatozoa were observed. Cytological preparations were unavailable.","SCO","SCO"]
["Proband_115","CS","NA","CS","CS","CS","CS","Yes","Severe oligoasthenozoospermia","The majority (90%) of the tubules observed in the histological sections contained complete spermatogenesis. The cytological preparations also indicated complete spermatogenesis.","CS","CS"]
["Proband_121","NP","NA","-","NP","pGCA","pGCA","yes","Azoospermia","Only cytology was availble for the description. Based on the number of spermatozoa observed the sample was classified as HS-mild","HS","HS-mild"]
["Proband_122","NP","GCA","GCA","NP","GCA","GCA","Yes","Azoospermia","In histology and cytology preparations spermatocytes were identified as being the most progressed germ cell stage. However, some spermatozoa were seen during inspection of the biopsy-derived cell suspension.","HS","HS-pGCA"]
["Proband_123","NA","NA","-","HS + pGCA","NA","HS + pGCA","yes","Azoospermia","No histology sample was available. In the cytology sample spermatoza were observed to such an extend that suggested HS-mild. This was also the case in the biopsy analysed for cryopreservation.","HS","HS-mild"]
["Proband_125","NA","NA","-","NA","NA","-","Yes","Azoospermia","TESE biopsy was performed elsewhere. ","Unknown","Unknown"]
["Proband_128","HS-pGCA","HS-pGCA","HS-pGCA","pGCA","HS + pGCA","pGCA","Yes","Azoospermia","Histological sections frequently showed tubules with meiotic arrest in addition to tubules with complete spermatogenesis. This was supported by the cytological analysis. ","HS","HS-pGCA"]
["Proband_129","SCO","SCO","SCO","SCO","NA","SCO","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_131","HS-severe","SCO","HS-severe","HS","SCO","HS","Yes","Azoospermia","Predominantly (95%) germ cell-devoid tubules were observed in the histological sections of the left biopsy, which showed pockets of tubules that contained complete spermatogenesis. In the biopsy from the other side no germ cells were seen. The frequency of spermatocytes and spermatozoa in the cytological preparation of the left biopsy were indicative for hypospermatogenesis. In the cytological preparation of the right biopsy no germ cells were observed.","HS","HS-severe"]
["Proband_132","HS-severe","HS-severe","HS-severe","HS + pGCA","HS","HS","Yes","Azoospermia","Both the histological sections as well as cytological preparations indicated hypospermatogenesis. Predominantly (~75%) tubules without germ cells were present in addition to some tubules that contained complete spermatogenesis. This was confirmed by the cytology preparations.  The spermatocyte/spermatozoa ratio of the left biopsy indicated a partial maturation arrest.","HS","HS-severe"]
["Proband_134","HS-severe","HS-severe","HS-severe","HS","HS","HS","yes","Extreme oligozoospermia","The majority of tubules both in the left and right biopsy showed only Sertoli cells. Occasionaly tubules with germ cells were present. In a subset of these elongating spermatids were observed. The hypospermatogenesis was confirmed by the cytology preparations","HS","HS-severe"]
["Proband_137","HS-pGCA","HS-pGCA","HS-pGCA","SCO/minimal GCA","SCO/minimal GCA","SCO/minimal GCA","yes","Azoospermia","Histology showed severly thinned epithelium in both biopsies. Frequently tubules with spermatcytes as most progressed state were present. Occasionally elongating spermatids were observed. In comparison, the cytology preparation showed a lower number of germ cells and no spermatozoa were detected.","HS","HS-pGCA"]
["Proband_138","CS","CS","CS","NA","CS","CS","yes","Severe oligozoospermia","Most tubules contained elongating spermatids though several tubules showed a thinned epitithelium. Overall this was confirmed by the cytology preparation.","CS","CS"]
["Proband_140","HS-severe","HS-severe","HS-severe","HS + pGCA","HS","HS","yes","Azoospermia","The majority of tubules both in the left and right biopsy showed only Sertoli cells. Occasionaly tubules with all germ cells stages were present. Overall this was confirmed by the cytology preparations.","HS","HS-severe"]
["Proband_141","HS-pGCA","HS-pGCA","HS-pGCA","CS","CS","CS","yes","Azoospermia","Both biopsies showed numerous tubules that contained spermatocytes as most progressed stages. In some tubules further maturation occured and in a subset of these tubules elongated spermatids were also present. Extensive hyalinisation was noted. The cytology preparations indicated a complete spermatogenesis","HS","HS-pGCA"]
["Proband_142","CS","NA","CS","HS","NA","HS","yes","Azoospermia","Less than 30 tubules were available for analysis. Most of these showed normal to mildly reduced spermatogenesis. In some cases the epithelium was severely thinned and lacking in spermatids. The cytology preparation indicated a hypospermatogenesis.","CS","CS"]
["Proband_143","HS-severe","SCO/minimal GCA","HS-severe","SCO","SCO","SCO","yes","Azoospermia","Both biopsies predominantly showed tubules that only contained Sertoli cells. However, in the left biopsy some patches of complete spermatogenesis were observed whereas in the right biopsy in rare instances incomplete spermatogenesis was observed. In the cytology preparations no germ cells were observed.","HS","HS-severe"]
["Proband_144","CS","HS-severe","CS","HS","HS + pGCA","HS","Yes","Azoospermia","Quality of spermatogenesis varied largely between left and right biopsies. In the left biopsy the majority of the tubules contained complete spermatogenesis although germ cell number did appear reduced in the epithelium. In the right biopsy germ cell-devoid tubules were predominantly observed while pockets of tubules containing spermatogenesis only occasionally.","CS","CS"]
["Proband_148","SCO","SCO","SCO","SCO","SCO","SCO","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_149","SCO","SCO","SCO","NA","NA","-","yes","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. No cytology preparations were available. Spermatozoa were obseved in the sample prepared for cryopreservation.","HS","HS-severe"]
["Proband_150","SCO","SCO","SCO","SCO/minimal GCA","SCO/minimal GCA","SCO/minimal GCA","no","Azoospermia","A complete lack of germ cells was observed in this biopsy while Sertoli cells were present. However, some spermatocytes were observed in the cytology preparations.","SCO/minimal GCA","SCO/minimal GCA"]
["Proband_151","SCO/minimal-GCA","SCO/minimal-GCA","SCO/minimal GCA","SCO/minimal MA","SCO/minimal MA","SCO/minimal MA","No","Azoospermia","In the histological sections tubules devoid of germ cells were predominantly present. However, occasionally spermatocytes were observed. This was corroborated by the cytological analysis. ","SCO/minimal GCA","SCO/minimal GCA"]
["Proband_152","GCA in spermiogenesis","GCA in spermiogenesis","GCA-round spermatid","CS, spermatid morphology aberrant","CS, spermatid morphology aberrant","CS, spermatid morphology aberrant","No","Azoospermia","Uniform maturation arrest in spermiogenesis. Spermatids arrested prior to elongation.","GCA","GCA-spermiogenesis"]
["Proband_153","SCO","SCO","SCO","SCO","SCO/minimal MA","SCO/minimal MA","Yes","Azoospermia","No germ cells were obsered in the histological preparations. The cytological analysis showed that spermatocytes were present in the right-side biopsy but a completely lacked in the left-side biopsy. Howevere, spermatozoa were seen during inspection of the biopsy-derived cell suspension, indicating hypospermatogenesis.","HS","HS-severe"]
["Proband_155","SCO","SCO","SCO","SCO","SCO","SCO","yes","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. This was confirmed by the cytology preparations. However, spermatozoa were obseved in the sample prepared for cryopreservation.","HS","HS-severe"]
["Proband_156","SCO","SCO","SCO","HS","SCO/minimal GCA","HS","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. The cytology preparations, however, indicated hypospermatogenesis. No spermatozoa were obseved in the sample prepared for cryopreservation.","HS","HS-severe"]
["Proband_157","SCO","SCO","SCO","SCO/minimal GCA","SCO/minimal GCA","SCO/minimal GCA","no","Azoospermia","A complete lack of germ cells was observed in this biopsy while Sertoli cells were present. However, some spermatocytes were observed in the cytology preparations.","SCO/minimal GCA","SCO/minimal GCA"]
["Proband_159","SCO","SCO","SCO","NA","NA","-","yes","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. No cytology preparations were available. Spermatozoa were obseved in the sample prepared for cryopreservation.","HS","HS-severe"]
["Proband_160","GCA-meiotic","GCA-meiotic","GCA-meiotic","SCO","SCO/minimal GCA","SCO/minimal GCA","no","Azoospermia","In both biopsies the epithelium of all tubules was severely thinned. In most tubules some spermatocytes were observed though in some only spermatogonia. The reduced numbers were confirmed by the cytology preparations.","GCA","GCA-meiotic"]
["Proband_161","SCO","SCO","SCO","SCO","SCO","SCO","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_162","GCA-round spermatid","NP","GCA-round spermatid","NA","CS","CS (abberent spermatid morphology)","no","Extreme oligozoospermia","In this biopsy spermatogenesis was arrested at the round spermatid stage. No elongated spermatids were observed in the cytology preparations, instead condensed round spermatids were quantified. ","GCA","GCA-round spermatid"]
["Proband_163","HS-severe","HS-severe","HS-severe","HS","HS","HS","yes","Azoospermia","Both biopsies predominantly showed tubules that only contained Sertoli cells. In some tubules all stages of spermatogenesis were observed but always in diminished density. Several tubules were completely hyalinised. This was overall confirmed by the cytology preparations.","HS","HS-severe"]
["Proband_164","HS-severe","HS-severe","HS-severe","HS","HS","HS","yes","Azoospermia","Both biopsies predominantly showed tubules that only contained Sertoli cells. In some tubules all stages of spermatogenesis were observed but always in diminished density. In another small subset of tubules only spermatogonia were present in addition to Sertoli cells. This was overall confirmed by the cytology preparations. ","HS","HS-severe"]
["Proband_165","NP","HS-pGCA","HS-pGCA","NP","HS + pGCA","HS + pGCA","yes","Extreme oligozoospermia","In the biopsy all tubules contained germ cells. Some tubules presented with a meiotic arrest whereas in other tubules a round spermatid arrest was observed. However, patches of complete spermatogenesis were also infrequently observed. This was overall confirmed by the cytology preparations. ","HS","HS-pGCA"]
["Proband_166","SCO","SCO","SCO","SCO","SCO","SCO","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present. This was confirmed by cytology.","SCO","SCO"]
["Proband_167","CS","HS-severe","CS","CS","HS","CS","yes","Azoospermia","In the left biopsy the majority of the tubules contain all stages of spermatogenesis. The density of germ cells in the epithelium is somewhat reduced. In the biopsy form the right side only a minority of the tubules contain traces of spermatogenesis. In addition, numurous tubules have undergone extensive hyalinization. This was overall confirmed by the cytology preparations. ","CS","CS"]
["Proband_168","SCO","HS-mild","HS-mild","HS","CS","CS","yes","Extreme oligozoospermia","In the left biopsy no germ cells were present in the tubules whereas in the right biopsy a significant part of the tubules contained complete spermatogenesis. The cytology preparation of the left biopsy did not confirm the SCO phenotype. For the right side histology and cytology were congruent. ","CS","CS"]
["Proband_169","HS-mild","HS-mild","HS-mild","HS + pGCA","HS + pGCA","HS + pGCA","yes","Azoospermia","In both biopsies elongating spermatids were regularly observed. The cytology preparations suggested a maturation arrest.","HS","HS-mild"]
["Proband_170","HS-mild","GCA-spermatogonia","HS-mild","HS + pGCA","HS","HS + pGCA","yes","Azoospermia","A stark difference was observed between both testis. The left biopsy showed normal spermatogenesis in ~45% of the tubules. The remainder of the tubules predominantly showed spermatogonia as most progressed stage. In the right biopsy only tubules with incomplete spermatogenesis were observed. Most tubules showed spermatogonia as the sole germ cell type, though spermatocytes were occasionally detected. These findings were reflected in the cytology preparations","HS","HS-Mild"]
["Proband_171","SCO","SCO","SCO","NA","NA","-","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present.  Reduced tubule calibre and mild basal lamina thickening was noted.","SCO","SCO"]
["Proband_172","GCA-round spermatid","GCA-round spermatid","GCA-round spermatid","NA","NA","-","no","Azoospermia","In both biopsies spermatogenesis was arrested at the round spermatid stage in all viable tubules.","GCA","GCA-round spermatid"]
["Proband_173","SCO","SCO","SCO","NA","NA","-","yes","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present.  Reduced tubule calibre and mild basal lamina thickening in most tubules was noted.","HS","HS-severe"]
["Proband_174","SCO","SCO","SCO","NA","NA","-","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present.","SCO","SCO"]
["Proband_175","100% hyalinised tubules","100% hyalinised tubules","SCO","NA","NA","-","no","Azoospermia","Right no viable tubules.  Left germ cell neoplasia in situ in 3% tubules, remainder of tubules hyalinised.","TS","Tubular shadows"]
["Proband_176","SCO","SCO","SCO","NA","NA","-","yes","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present.  Reduced tubule calibre and basal lamina thickening was noted.","HS","HS-severe"]
["Proband_179","SCO","SCO/Minimal GCA","SCO/minimal GCA","NA","NA","-","yes","Azoospermia","In both biopsies most tubules contained only Sertoli cells. Some tubules, however contained spermatogonia through to round spermatids; no elongated spermatids were identified.","HS","HS-severe"]
["Proband_180","SCO","SCO/Minimal GCA ","SCO/minimal GCA","NA","NA","-","yes","Azoospermia","In both biopsies most tubules contained only Sertoli cells. Some tubules, however contained spermatogonia through to rounded spermatids; no elongated spermatids were identified.","HS","HS-severe"]
["Proband_182","SCO/Minimal GCA","SCO/Minimal GCA","SCO/minimal GCA","NA","NA","-","yes","Azoospermia","In both biopsies most tubules contained only Sertoli cells. Some tubules, however contained spermatogonia though to rounded spermatids; no elongated spermatids were identified.","HS","HS-severe"]
["Proband_183","HS-mild","GCA-round spermatid","HS-mild","NA","NA","-","no","Azoospermia","Germ cells are present in all tubules and in a subset of these as elongating spermatids (50%)","HS","HS-mild"]
["Proband_184","GCA-round spermatid","GCA-round spermatid","GCA-round spermatid","NA","NA","-","no","Azoospermia","Approximately 50% of the tubels lacked germ cells. In the tubules that contained germ cells the majority of these showed round spermatids. However, also tubules with earlier arrest were observed.","GCA","GCA-round spermatid"]
["Proband_185","SCO","SCO","SCO","NA","NA","-","no","Azoospermia","A complete lack of germ cells was observed in both biopsies while Sertoli cells were present.  Reduced tubule calibre and mild basal lamina thickening was noted.","SCO","SCO"]

{"sheet":"Table 5 Cytology data","index":4,"n_rows":104,"n_cols":13,"rows_kept":104,"merged":[[0,0,1,0],[0,1,0,3],[0,4,0,6],[0,10,0,11]]}
["Patient ID","Biopsy left side",null,null,"Ratio's left side",{"$nulls":3},"Biopsy right side",null,"Ratio's left side"]
[null,"Nr. Sertoli cells","Nr. spermatocytes","Nr. spermatozoa","Spermatocytes/spermatozoa","Spermatozoa/Sertoli cells*100","Conclusion","Nr. Sertoli cells","Nr. spermatocytes","Nr. spermatozoa","Spermatocytes/spermatozoa","Spermatzoa/Sertoli cells*100","Conclusion"]
["Proband_001",226,3,2,1.5,{"v":0.8849557522123894,"d":"1"},"HS","NP","NP","NP","- ","- ","- "]
["Proband_002",390,12,0,"- ","- ","SCO/minimal GCA",389,11,0,"- ","- ","SCO/minimal GCA"]
["Proband_003",500,0,0,"-","-","SCO",265,55,108,0.5,{"$f":"J5/H5*100","v":{"v":40.75471698113208,"d":"41"}},"CS"]
["Proband_004",400,0,0,"-","-","SCO",400,0,0,"-","-","SCO"]
["Proband_005",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_006",382,18,0,"- ","- ","SCO/minimal GCA",380,24,0,"- ","- ","SCO/minimal GCA"]
["Proband_007",400,0,0,"- ","- ","SCO","NA","NA","NA","- ","- ","- "]
["Proband_008",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_009",400,0,0,"-","-","SCO","NP","NP","NP","-","-","-"]
["Proband_010","NA","NA","NA","- ","- ","- ","NP","NP","NP","- ","- ","NA"]
["Proband_011",400,0,0,"-","-","SCO",400,0,0,"-","-","SCO"]
["Proband_012","NP","NP","NP","- ","- ","- ",151,183,66,2.8,{"v":43.70860927152318,"d":"44"},"pGCA"]
["Proband_013",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_014","NP","NP","NP","- ","- ","- ",400,0,0,"- ","- ","SCO"]
["Proband_015",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_016","NP","NP","NP","-","-","-",400,0,0,"-","-","SCO"]
["Proband_017",379,10,11,0.9,{"v":2.9023746701846966,"d":"3"},"HS + pGCA","NA","NA","NA","- ","- ","- "]
["Proband_018",402,18,0,"- ","- ","SCO/minimal GCA","NP","NP","NP","- ","- ","- "]
["Proband_019",400,0,0,"- ","- ","SCO","NP","NP","NP","- ","- ","- "]
["Proband_020","NP","NP","NP","- ","- ","- ",400,0,0,"- ","- ","SCO"]
["Proband_021",400,0,0,"- ","- ","SCO","NP","NP","NP","- ","- ","- "]
["Proband_022","NP","NP","NP","- ","- ","- ",400,0,0,"- ","- ","SCO"]
["Proband_023","NA","NA","NA","- ","- ","- ","NP","NP","NP","- ","- ","- "]
["Proband_024",389,7,4,1.8,{"v":1.0282776349614395,"d":"1"},"HS","NA","NA","NA","- ","- ","- "]
["Proband_025",398,5,0,"- ","- ","SCO/minimal GCA",200,0,0,"- ","- ","SCO"]
["Proband_026","NP","NP","NP","- ","- ","- ",393,5,3,1.7,{"v":0.7633587786259541,"d":"1"},"HS"]
["Proband_027",132,169,125,1.4,{"v":94.6969696969697,"d":"95"},"pGCA","NP","NP","NP","- ","- ","- "]
["Proband_028",381,19,0,"-","-","SCO/minimal GCA",386,15,0,"-","-","SCO/minimal GCA"]
["Proband_029","NP","NP","NP","- ","- ","- ",398,2,0,"- ","- ","SCO/minimal GCA"]
["Proband_030",219,92,89,{"$f":"C32/D32","v":{"v":1.0337078651685394,"d":"1.0"}},{"$f":"D32/B32*100","v":{"v":40.63926940639269,"d":"41"}},"CS","NP","NP","NP","-","-","-"]
["Proband_031",398,2,0,"-","-","SCO/minimal GCA",399,1,0,"-","-","SCO/minimal GCA"]
["Proband_032",382,17,1,17,{"v":0.2617801047120419,"d":"0"},"HS",269,56,75,0.7,{"v":27.881040892193308,"d":"28"},"CS"]
["Proband_033","NP","NP","NP","- ","- ","- ",400,0,0,"- ","- ","SCO"]
["Proband_034",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_035",385,9,6,1.5,{"v":1.5584415584415585,"d":"2"},"HS","NA","NA","NA","- ","- ","- "]
["Proband_036",400,0,0,"-","-","SCO","NP","NP","NP","-","-","-"]
["Proband_037","NP","NP","NP","- ","- ","- ",271,68,62,1.1,{"v":22.878228782287824,"d":"23"},"pGCA"]
["Proband_038",388,10,1,10,{"v":0.25773195876288657,"d":"0"},"HS","NP","NP","NP","- ","- ","- "]
["Proband_039",400,0,0,"- ","- ","SCO","NA","NA","NA","- ","- ","- "]
["Proband_040","NP","NP","NP","-","-","-",367,36,24,{"$f":"I42/J42","v":1.5},{"$f":"J42/H42*100","v":{"v":6.539509536784741,"d":"7"}},"HS + pGCA"]
["Proband_041",359,30,11,{"$f":"C43/D43","v":{"v":2.727272727272727,"d":"2.7"}},{"$f":"D43/B43*100","v":{"v":3.064066852367688,"d":"3"}},"HS + pGCA","NP","NP","NP","-","-","-"]
["Proband_042",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_043",379,21,1,{"$f":"C45/D45","v":{"v":21,"d":"21.0"}},{"$f":"D45/B45*100","v":{"v":0.2638522427440633,"d":"0.3"}},"HS + pGCA","NP","NP","NP","-","-","-"]
["Proband_044",388,9,3,{"$f":"C46/D46","v":{"v":3,"d":"3.0"}},{"$f":"D46/B46*100","v":{"v":0.7731958762886598,"d":"1"}},"HS","NP","NP","NP","-","-","-"]
["Proband_045","NP","NP","NP","- ","- ","- ",400,0,0,"- ","- ","SCO"]
["Proband_046",412,6,0,"- ","- ","SCO/minimal GCA",199,80,124,0.6,{"$f":"J48/H48*100","v":{"v":62.311557788944725,"d":"62"}},"CS"]
["Proband_047",400,0,0,"-","-","SCO",400,0,0,"-","-","SCO"]
["Proband_048",387,10,4,2.5,{"$f":"D50/B50*100","v":{"v":1.03359173126615,"d":"1"}},"HS",396,3,1,3,{"$f":"J50/H50*100","v":{"v":0.25252525252525254,"d":"0"}},"HS"]
["Proband_053","NP","NP","NP","- ","- ","- ",367,20,17,1.2,{"v":4.632152588555858,"d":"5"},"HS + pGCA"]
["Proband_059",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_060","NA","NA","NA","- ","- ","- ","NA","NA","NA","- ","- ","- "]
["Proband_063",400,0,0,"- ","- ","SCO",394,5,2,2.5,{"v":0.5076142131979695,"d":"1"},"HS"]
["Proband_065",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_069","NA","NA","NA","-","-","-","NA","NA","NA","-","-","-"]
["Proband_070","NA","NA","NA","-","-","-","NA","NA","NA","-","-","-"]
["Proband_077",371,21,8,{"$f":"C58/D58","v":{"v":2.625,"d":"2.6"}},{"$f":"D58/B58*100","v":{"v":2.15633423180593,"d":"2"}},"HS + pGCA","NP","NP","NP","-","-","-"]
["Proband_079","NP","NP","NP","- ","- ","- ",399,1,0,"- ","- ","SCO/minimal GCA"]
["Proband_083",130,143,127,1.1,{"v":97.6923076923077,"d":"98"},"pGCA",143,147,111,1.3,{"v":77.62237762237763,"d":"78"},"pGCA"]
["Proband_086",365,15,20,{"$f":"C61/D61","v":{"v":0.75,"d":"0.8"}},{"$f":"D61/B61*100","v":{"v":5.47945205479452,"d":"5"}},"HS + pGCA",220,29,29,{"$f":"I61/J61","v":{"v":1,"d":"1.0"}},{"$f":"J61/H61*100","v":{"v":13.18181818181818,"d":"13"}},"HS + pGCA"]
["Proband_089",400,0,0,"-","-","SCO",397,3,0,"-","-","SCO/minimal GCA"]
["Proband_090","NA","NA","NA","- ","- ","NA","NA","NA","NA","- ","- ","- "]
["Proband_092",400,0,0,"- ","- ","SCO",400,0,0,"- ","- ","SCO"]
["Proband_095","NP","NP","NP","- ","- ","- ",281,58,61,1,{"v":21.70818505338078,"d":"22"},"pGCA"]
["Proband_096",390,8,2,4,{"v":0.5128205128205128,"d":"1"},"HS",380,13,7,1.9,{"v":1.8421052631578945,"d":"2"},"HS"]
["Proband_097",189,69,143,{"$f":"C67/D67","v":{"v":0.4825174825174825,"d":"0.5"}},{"$f":"D67/B67*100","v":{"v":75.66137566137566,"d":"76"}},"CS","NP","NP","NP","-","-","-"]
["Proband_106","NA","NA","NA","- ","- ","NA","NA","NA","NA","- ","- ","- "]
["Proband_115",166,66,168,0.4,{"v":101.20481927710843,"d":"101"},"CS",137,93,170,0.5,{"v":124.08759124087592,"d":"124"},"CS"]
["Proband_121","NP","NP","NP","-","-","-",262,62,76,{"$f":"I70/J70","v":{"v":0.8157894736842105,"d":"0.8"}},{"$f":"J70/H70*100","v":{"v":29.00763358778626,"d":"29"}},"pGCA"]
["Proband_122","NP","NP","NP","- ","- ","- ",270,130,0,"- ","- ","GCA"]
["Proband_123",311,70,19,{"$f":"C72/D72","v":{"v":3.6842105263157894,"d":"3.7"}},{"$f":"D72/B72*100","v":{"v":6.109324758842444,"d":"6"}},"HS + pGCA","NP","NP","NP","-","-","-"]
["Proband_128",220,117,63,1.9,{"v":28.636363636363637,"d":"29"},"pGCA",309,51,40,1.3,{"v":12.944983818770226,"d":"13"},"HS + pGCA"]
["Proband_129",400,0,0,"-","-","SCO","NA","NA","NA","-","-","-"]
["Proband_131",367,19,14,1.4,{"v":3.8147138964577656,"d":"4"},"HS",400,0,0,"- ","- ","SCO"]
["Proband_132",339,40,21,1.9,{"v":6.1946902654867255,"d":"6"},"HS + pGCA",394,4,2,2,{"v":0.5076142131979695,"d":"1"},"HS"]
["Proband_134",377,4,19,{"$f":"C77/D77","v":{"v":0.21052631578947367,"d":"0.2"}},{"$f":"D77/B77*100","v":{"v":5.039787798408488,"d":"5"}},"HS",383,4,14,{"$f":"I77/J77","v":{"v":0.2857142857142857,"d":"0.3"}},{"$f":"J77/H77*100","v":{"v":3.6553524804177546,"d":"4"}},"HS"]
["Proband_137",388,12,0,"-","-","SCO/minimal GCA",390,13,0,"-","-","SCO/minimal GCA"]
["Proband_138","NP","NP","NP","-","-","-",180,35,185,{"$f":"I79/J79","v":{"v":0.1891891891891892,"d":"0.2"}},{"$f":"J79/H79*100","v":{"v":102.77777777777777,"d":"103"}},"CS"]
["Proband_140",365,25,10,{"$f":"C80/D80","v":2.5},{"$f":"D80/B80*100","v":{"v":2.73972602739726,"d":"3"}},"HS + pGCA",380,12,8,{"$f":"I80/J80","v":1.5},{"$f":"J80/H80*100","v":{"v":2.1052631578947367,"d":"2"}},"HS"]
["Proband_141",264,58,78,{"$f":"C81/D81","v":{"v":0.7435897435897436,"d":"0.7"}},{"$f":"D81/B81*100","v":{"v":29.545454545454547,"d":"30"}},"CS","NA","NA","NA","-","-","-"]
["Proband_142",321,15,64,{"$f":"C82/D82","v":{"v":0.234375,"d":"0.2"}},{"$f":"D82/B82*100","v":{"v":19.937694704049843,"d":"20"}},"HS","NA","NA","NA","-","-","-"]
["Proband_143",400,0,0,"-","-","SCO",400,0,0,"-","-","SCO"]
["Proband_144",389,8,3,2.7,{"v":0.7712082262210797,"d":"1"},"HS",375,13,12,1.1,{"v":3.2,"d":"3"},"HS + pGCA"]
["Proband_148",400,0,0,"-","-","SCO",400,0,0,"-","-","SCO"]
["Proband_149","NA","NA","NA","-","-","-","NA","NA","NA","-","-","-"]
["Proband_150",398,2,0,"-","-","SCO/minimal GCA",399,1,0,"-","-","SCO/minimal GCA"]
["Proband_151",394,6,0,"- ","- ","SCO/minimal GCA",396,4,0,"- ","- ","SCO/minimal GCA"]
["Proband_152",187,107,108,1,{"v":57.75401069518716,"d":"58"},"CS, spermatid morphology aberrant",245,54,103,0.5,{"v":42.04081632653061,"d":"42"},"CS"]
["Proband_153",400,0,0,"- ","- ","SCO",390,10,0,"- ","- ","SCO/minimal GCA"]
["Proband_155",400,0,0,"-","-","SCO",400,0,0,"-","-","SCO"]
["Proband_156",395,4,1,{"$f":"C92/D92","v":{"v":4,"d":"4.0"}},{"$f":"D92/B92*100","v":{"v":0.25316455696202533,"d":"0.3"}},"HS",395,5,0,"-","-","SCO/minimal GCA"]
["Proband_157",395,5,0,"-","-","SCO/minimal GCA",394,6,0,"-","-","SCO/minimal GCA"]
["Proband_159","NA","NA","NA","-","-","-","NA","NA","NA","-","-","-"]
["Proband_160",400,0,0,"-","-","SCO",395,5,0,"-","-","SCO/minimal GCA"]
["Proband_161",400,0,0,"-","-","SCO",400,0,0,"-","-","SCO"]
["Proband_162","NA","NA","NA","-","-","-",263,47,90,{"$f":"I97/J97","v":{"v":0.5222222222222223,"d":"0.5"}},{"$f":"J97/H97*100","v":{"v":34.22053231939163,"d":"34"}},"CS"]
["Proband_163",394,5,4,{"$f":"C98/D98","v":{"v":1.25,"d":"1.3"}},{"$f":"D98/B98*100","v":{"v":1.015228426395939,"d":"1"}},"HS",375,10,11,{"$f":"I98/J98","v":{"v":0.9090909090909091,"d":"0.9"}},{"$f":"J98/H98*100","v":{"v":2.933333333333333,"d":"3"}},"HS"]
["Proband_164",388,7,7,{"$f":"C99/D99","v":{"v":1,"d":"1.0"}},{"$f":"D99/B99*100","v":{"v":1.804123711340206,"d":"2"}},"HS",391,5,4,{"$f":"I99/J99","v":{"v":1.25,"d":"1.3"}},{"$f":"J99/H99*100","v":{"v":1.0230179028132993,"d":"1"}},"HS"]
["Proband_165","NP","NP","NP","-","-","-",337,47,17,{"$f":"I100/J100","v":{"v":2.764705882352941,"d":"2.8"}},{"$f":"J100/H100*100","v":{"v":5.044510385756676,"d":"5"}},"HS + pGCA"]
["Proband_166",400,0,0,"-","-","SCO",400,0,0,"-","-","SCO"]
["Proband_167",239,34,130,{"$f":"C102/D102","v":{"v":0.26153846153846155,"d":"0.3"}},{"$f":"D102/B102*100","v":{"v":54.39330543933054,"d":"54"}},"CS",357,10,33,{"$f":"I102/J102","v":{"v":0.30303030303030304,"d":"0.3"}},{"$f":"J102/H102*100","v":{"v":9.243697478991598,"d":"9"}},"HS"]
["Proband_168",220,43,140,{"$f":"C103/D103","v":{"v":0.30714285714285716,"d":"0.3"}},{"$f":"D103/B103*100","v":{"v":63.63636363636363,"d":"64"}},"CS",378,6,16,{"$f":"I103/J103","v":{"v":0.375,"d":"0.4"}},{"$f":"J103/H103*100","v":{"v":4.232804232804233,"d":"4"}},"HS"]
["Proband_169",290,95,15,{"$f":"C104/D104","v":{"v":6.333333333333333,"d":"6.3"}},{"$f":"D104/B104*100","v":{"v":5.172413793103448,"d":"5"}},"HS + pGCA",306,56,38,{"$f":"I104/J104","v":{"v":1.4736842105263157,"d":"1.5"}},{"$f":"J104/H104*100","v":{"v":12.418300653594772,"d":"12"}},"HS + pGCA"]