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["Table S1. All intestinal microbiota taxa instrumental variables. "]
["exposure","level","SNP","effect_allele.exposure","other_allele.exposure","effect_allele.outcome","other_allele.outcome","beta.exposure","beta.outcome","eaf.exposure","eaf.outcome","se.outcome","pval.outcome","se.exposure","pval.exposure"]
["class.Actinobacteria.id.419","class","rs10841473","G","C","G","C",-0.058376469,0.0331,"NA",0.2317,0.0197,0.0927598,0.012335331,{"v":2.59e-06,"d":"2.59E-06"}]
["class.Actinobacteria.id.419","class","rs11655079","T","C","T","C",-0.056067443,0.0169,"NA",0.1868,0.0215,0.432,0.01242856,{"v":5.93e-06,"d":"5.93E-06"}]
["class.Actinobacteria.id.419","class","rs11745923","G","T","G","T",0.056375863,-0.0342,"NA",0.3936,0.0171,0.0453002,0.011552908,{"v":1.58e-06,"d":"1.58E-06"}]
["class.Actinobacteria.id.419","class","rs12049045","A","G","A","G",0.05104521,0.0075,"NA",0.383,0.0171,0.6586,0.01143249,{"v":8.63e-06,"d":"8.63E-06"}]
["class.Actinobacteria.id.419","class","rs12899991","A","T","A","T",0.071992324,-0.0122,"NA",0.2442,0.0196,0.5327,0.015466108,{"v":4.03e-06,"d":"4.03E-06"}]
["class.Actinobacteria.id.419","class","rs134366","G","A","G","A",0.111876589,0.0755,"NA",0.0688,0.0333,0.0232498,0.023500975,{"v":1.5e-06,"d":"1.50E-06"}]
["class.Actinobacteria.id.419","class","rs1376754","G","A","G","A",0.050924155,-0.0108,"NA",0.4932,0.0167,0.5194,0.011250292,{"v":6.71e-06,"d":"6.71E-06"}]
["class.Actinobacteria.id.419","class","rs1515761","T","C","T","C",0.076231731,-0.0445,"NA",0.0750999999999999,0.032,0.1645,0.016988402,{"v":4.96e-06,"d":"4.96E-06"}]
["class.Actinobacteria.id.419","class","rs182549","C","T","C","T",0.111489458,-0.0041,"NA",0.4024,0.017,0.808,0.012065989,{"v":3.79e-20,"d":"3.79E-20"}]
["class.Actinobacteria.id.419","class","rs4945008","A","G","A","G",0.054074066,0.0215,"NA",0.3909,0.0171,0.2085,0.012139345,{"v":5.39e-06,"d":"5.39E-06"}]
["class.Actinobacteria.id.419","class","rs6660520","A","G","A","G",0.071148271,-0.0135,"NA",0.2713,0.0187,0.4716,0.013449539,{"v":1.11e-07,"d":"1.11E-07"}]
["class.Actinobacteria.id.419","class","rs72767435","T","C","T","C",-0.126352156,-0.0275,"NA",0.05497,0.0368,0.4543,0.027362598,{"v":2.57e-06,"d":"2.57E-06"}]
["class.Actinobacteria.id.419","class","rs7322849","T","C","T","C",0.094446681,0.0508,"NA",0.09186,0.0291,0.0804192,0.019297598,{"v":6.21e-07,"d":"6.21E-07"}]
["class.Actinobacteria.id.419","class","rs7700479","T","A","T","A",-0.076965305,0.0024,"NA",0.1054,0.0277,0.9323,0.017393272,{"v":8.62e-06,"d":"8.62E-06"}]
["class.Actinobacteria.id.419","class","rs80083040","T","G","T","G",0.155783797,0.0416,"NA",0.04419,0.0409,0.3094,0.034801661,{"v":8.62e-06,"d":"8.62E-06"}]
["class.Actinobacteria.id.419","class","rs8047955","A","G","A","G",0.05758155,-0.016,"NA",0.382,0.0171,0.3509,0.011676216,{"v":8.34e-07,"d":"8.34E-07"}]
["class.Actinobacteria.id.419","class","rs857444","C","T","C","T",0.050955263,-0.0067,"NA",0.3684,0.0173,0.6996,0.011539048,{"v":8.92e-06,"d":"8.92E-06"}]
["class.Actinobacteria.id.419","class","rs961091","G","A","G","A",0.050125533,0.0265,"NA",0.3718,0.0173,0.1264,0.01125498,{"v":8.68e-06,"d":"8.68E-06"}]
["class.Betaproteobacteria.id.2867","class","rs11128180","A","G","A","G",0.059294412,-0.0124,"NA",0.2322,0.0197,0.5273,0.012876923,{"v":3.67e-06,"d":"3.67E-06"}]
["class.Betaproteobacteria.id.2867","class","rs12467854","G","C","G","C",0.06413625,-0.0074,"NA",0.2111,0.0205,0.7183,0.013176625,{"v":1.1e-06,"d":"1.10E-06"}]
["class.Betaproteobacteria.id.2867","class","rs1511453","A","G","A","G",0.092349246,0.053,"NA",0.05809,0.0357,0.1371,0.019915827,{"v":4.76e-06,"d":"4.76E-06"}]
["class.Betaproteobacteria.id.2867","class","rs1928341","A","G","A","G",0.052558097,{"v":0.0008,"d":"8.00E-04"},"NA",0.405,0.017,0.9641,0.011040784,{"v":2.02e-06,"d":"2.02E-06"}]
["class.Betaproteobacteria.id.2867","class","rs2321387","G","A","G","A",-0.049459619,0.036,"NA",0.4303,0.0168,0.0326197,0.010942399,{"v":5.8e-06,"d":"5.80E-06"}]
["class.Betaproteobacteria.id.2867","class","rs2367850","G","C","G","C",0.064005972,0.0067,"NA",0.2221,0.0204,0.743201,0.013037436,{"v":9.12e-07,"d":"9.12E-07"}]
["class.Betaproteobacteria.id.2867","class","rs2613606","C","T","C","T",-0.051310589,-0.0282,"NA",0.4189,0.0169,0.0954399,0.010909103,{"v":2.2e-06,"d":"2.20E-06"}]
["class.Betaproteobacteria.id.2867","class","rs320161","A","G","A","G",0.057228557,-0.0483,"NA",0.2308,0.02,0.0157,0.012619964,{"v":7.33e-06,"d":"7.33E-06"}]
["class.Betaproteobacteria.id.2867","class","rs4033856","C","T","C","T",0.083242265,0.0356,"NA",0.0866,0.0294,0.2256,0.016723677,{"v":5.17e-07,"d":"5.17E-07"}]
["class.Betaproteobacteria.id.2867","class","rs56386628","C","T","C","T",-0.062225169,0.0138,"NA",0.2569,0.019,0.4677,0.013568762,{"v":5.87e-06,"d":"5.87E-06"}]
["class.Betaproteobacteria.id.2867","class","rs6087811","T","G","T","G",-0.097817738,-0.0162,"NA",0.1015,0.0276,0.5566,0.019852201,{"v":7.44e-07,"d":"7.44E-07"}]
["class.Betaproteobacteria.id.2867","class","rs62395635","T","C","T","C",0.109740893,0.0045,"NA",0.06223,0.0344,0.8966,0.02360002,{"v":2.94e-06,"d":"2.94E-06"}]
["class.Betaproteobacteria.id.2867","class","rs72747231","C","G","C","G",-0.137280671,-0.0316,"NA",0.04776,0.0399,0.4287,0.029033768,{"v":2.06e-06,"d":"2.06E-06"}]
["class.Betaproteobacteria.id.2867","class","rs75242906","C","T","C","T",-0.121083253,0.0487,"NA",0.08367,0.0304,0.1094,0.028074987,{"v":9.27e-06,"d":"9.27E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs1035691","A","G","A","G",-0.055175977,-0.0169,"NA",0.4036,0.0171,0.3209,0.012160175,{"v":9.65e-06,"d":"9.65E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs112381107","C","T","C","T",0.206594184,0.0704,"NA",0.05988,0.0349,0.0438904,0.045690815,{"v":4.63e-06,"d":"4.63E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs11599763","T","C","T","C",-0.054421883,{"v":-0.0006,"d":"-6.00E-04"},"NA",0.408,0.0171,0.9732,0.011739659,{"v":3.94e-06,"d":"3.94E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs16851319","G","C","G","C",-0.07055156,0.0209,"NA",0.1775,0.022,0.3427,0.015084942,{"v":5.68e-06,"d":"5.68E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs17084793","G","A","G","A",-0.071076166,0.0483,"NA",0.1465,0.0237,0.04132,0.015953009,{"v":5.69e-06,"d":"5.69E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs17791387","A","G","A","G",-0.073588121,0.0132,"NA",0.0952,0.0284,0.643899,0.015424623,{"v":1.6e-06,"d":"1.60E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs2692012","A","G","A","G",0.1103349,-0.0102,"NA",0.0551,0.0364,0.7798,0.025333574,{"v":3.14e-06,"d":"3.14E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs2838334","G","A","G","A",0.056172159,0.0286,"NA",0.3438,0.0175,0.1021,0.012412391,{"v":5.45e-06,"d":"5.45E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs3935584","C","T","C","T",-0.052348451,0.0083,"NA",0.5312,0.0167,0.6193,0.011566041,{"v":7.5e-06,"d":"7.50E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs4506934","C","T","C","T",-0.093651362,-0.0362,"NA",0.1182,0.026,0.1635,0.020120034,{"v":3.59e-06,"d":"3.59E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs55744759","A","G","A","G",-0.077969339,-0.0337,"NA",0.1122,0.0266,0.2047,0.017073844,{"v":7.31e-06,"d":"7.31E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs6058181","C","T","C","T",0.082571565,-0.0329,"NA",0.1627,0.0226,0.1459,0.016595819,{"v":3.4e-07,"d":"3.40E-07"}]
["class.Deltaproteobacteria.id.3087","class","rs62020470","A","G","A","G",-0.058541133,-0.0146,"NA",0.1797,0.0218,0.5044,0.012935848,{"v":4.85e-06,"d":"4.85E-06"}]
["class.Deltaproteobacteria.id.3087","class","rs9928243","C","A","C","A",-0.053845737,-0.0013,"NA",0.4706,0.0167,0.9391,0.011771796,{"v":5.02e-06,"d":"5.02E-06"}]
["class.Methanobacteria.id.119","class","rs10202904","T","G","T","G",-0.121753579,0.0015,"NA",0.4085,0.017,0.9305,0.023535682,{"v":3.01e-07,"d":"3.01E-07"}]
["class.Methanobacteria.id.119","class","rs10424197","G","A","G","A",-0.111274175,0.0121,"NA",0.2577,0.0193,0.5294,0.024751678,{"v":9.28e-06,"d":"9.28E-06"}]
["class.Methanobacteria.id.119","class","rs11018665","A","T","A","T",0.111465287,0.0012,"NA",0.2416,0.0195,0.9521,0.025051554,{"v":6.52e-06,"d":"6.52E-06"}]
["class.Methanobacteria.id.119","class","rs12825290","C","G","C","G",-0.216781075,-0.062,"NA",0.06134,0.0347,0.0738992,0.049349641,{"v":6.08e-06,"d":"6.08E-06"}]
["class.Methanobacteria.id.119","class","rs4257531","G","A","G","A",0.164498365,0.0235,"NA",0.1058,0.0274,0.3905,0.03649593,{"v":7.44e-06,"d":"7.44E-06"}]
["class.Methanobacteria.id.119","class","rs56131665","G","A","G","A",0.178661188,-0.0139,"NA",0.1072,0.0269,0.6058,0.039297982,{"v":6.18e-06,"d":"6.18E-06"}]
["class.Methanobacteria.id.119","class","rs62241835","G","T","G","T",-0.203385443,0.0484,"NA",0.0206,0.06,0.4196,0.041793099,{"v":1.63e-06,"d":"1.63E-06"}]
["class.Methanobacteria.id.119","class","rs6508769","T","C","T","C",0.15351913,-0.0333,"NA",0.1465,0.0236,0.1585,0.034451866,{"v":8.23e-06,"d":"8.23E-06"}]
["class.Methanobacteria.id.119","class","rs73068003","G","T","G","T",-0.158140381,0.0023,"NA",0.09661,0.0285,0.9367,0.035180317,{"v":8.45e-06,"d":"8.45E-06"}]
["class.Methanobacteria.id.119","class","rs73457410","A","G","A","G",0.215339755,-0.0171,"NA",0.06377,0.0346,0.6215,0.04366952,{"v":1.41e-06,"d":"1.41E-06"}]
["class.Methanobacteria.id.119","class","rs75208022","C","T","C","T",-0.227244713,-0.0136,"NA",0.09314,0.0289,0.639,0.048763001,{"v":5.92e-06,"d":"5.92E-06"}]
["class.Methanobacteria.id.119","class","rs894996","C","A","C","A",0.216999069,0.0548,"NA",0.0703,0.033,0.0967498,0.044907554,{"v":1.88e-06,"d":"1.88E-06"}]
["class.Alphaproteobacteria.id.2379","class","rs10803434","A","T","A","T",-0.069274224,-0.0186,"NA",0.4741,0.0167,0.2646,0.01488663,{"v":3.55e-06,"d":"3.55E-06"}]
["class.Alphaproteobacteria.id.2379","class","rs12977163","G","C","G","C",0.069023356,-0.0026,"NA",0.3903,0.0171,0.8814,0.015382895,{"v":7.14e-06,"d":"7.14E-06"}]
["class.Alphaproteobacteria.id.2379","class","rs140912403","C","T","C","T",-0.160677133,0.0103,"NA",0.05784,0.0355,0.7718,0.031770756,{"v":6.2e-07,"d":"6.20E-07"}]
["class.Alphaproteobacteria.id.2379","class","rs17061716","G","C","G","C",0.092734145,0.0075,"NA",0.1571,0.0229,0.744399,0.020756923,{"v":9.33e-06,"d":"9.33E-06"}]
["class.Alphaproteobacteria.id.2379","class","rs34569731","A","G","A","G",0.070514454,-0.0171,"NA",0.4243,0.0173,0.3244,0.015756373,{"v":7.38e-06,"d":"7.38E-06"}]
["class.Alphaproteobacteria.id.2379","class","rs55876211","C","T","C","T",-0.080810954,0.0234,"NA",0.2537,0.0191,0.2206,0.01841593,{"v":7.54e-06,"d":"7.54E-06"}]
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["class.Alphaproteobacteria.id.2379","class","rs9813022","A","G","A","G",-0.075127704,0.0256,"NA",0.3755,0.0172,0.1367,0.015386652,{"v":1.05e-06,"d":"1.05E-06"}]
["class.Bacilli.id.1673","class","rs11110282","A","G","A","G",-0.101189316,-0.0184,"NA",0.04838,0.0392,0.6388,0.021737883,{"v":4.85e-06,"d":"4.85E-06"}]
["class.Bacilli.id.1673","class","rs111552159","C","G","C","G",0.128031637,-0.0382,"NA",0.04487,0.041,0.351,0.028692104,{"v":9.13e-06,"d":"9.13E-06"}]
["class.Bacilli.id.1673","class","rs11730038","G","A","G","A",-0.063074683,0.0044,"NA",0.2932,0.0184,0.8115,0.012871737,{"v":1.96e-06,"d":"1.96E-06"}]
["class.Bacilli.id.1673","class","rs12797734","T","C","T","C",0.057215761,-0.0305,"NA",0.262,0.0194,0.1161,0.012679292,{"v":7.21e-06,"d":"7.21E-06"}]
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["class.Bacilli.id.1673","class","rs1595463","C","A","C","A",0.04768644,-0.0214,"NA",0.5388,0.0168,0.2038,0.010854727,{"v":7.97e-06,"d":"7.97E-06"}]
["class.Bacilli.id.1673","class","rs1962325","C","G","C","G",0.055421868,-0.0161,"NA",0.3374,0.0177,0.3612,0.011478925,{"v":1.38e-06,"d":"1.38E-06"}]
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["class.Bacilli.id.1673","class","rs2952251","A","G","A","G",-0.059886787,0.0096,"NA",0.2289,0.0218,0.6617,0.012390272,{"v":1.08e-06,"d":"1.08E-06"}]
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["class.Bacilli.id.1673","class","rs77558518","A","G","A","G",-0.107254772,{"v":0.0007,"d":"7.00E-04"},"NA",0.09593,0.0283,0.9796,0.022287875,{"v":1.34e-06,"d":"1.34E-06"}]
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["SNP, single nucleotide polymorphism；effect_allele= effect alleles; other_allele=minor allele; beta.exposure=effect size of SNP on exposure; beta.outcome=effect size of SNP on outcome; eaf.exposure=Effect allele frequency for exposure; eaf.outcome=Effect allele frequency for outcome；se.outcome=standard error for outcome; se.exposure=standard error for exposure; pval.outcome=p-value for outcome; pval.exposure=p-value for exposure; "]