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["The limits of inductive reasoning for clinical evidence appraisal - a simulation study"]
["Steffen Mickenautsch, Veerasamy Yengopal"]
[]
["Additional file",{"$nulls":5},"TP = True positive; FP = False positive; FN = False negative; TN = True negative"]
[{"$nulls":7},"Correctly identified error"]
["Section 1: Randomly generated data"]
[]
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["Appraisal of error domains: ",null,null,3,13,18,23,46,{"$nulls":3},"Appraisal of error domains: ",null,null,3,13,18,23,46,{"$nulls":3},"Appraisal of error domains: ",null,null,3,13,18,23,46]
["Run Nr",23,{"$nulls":9},"Run Nr",24,{"$nulls":9},"Run Nr",25]
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[5,5,1,2,36,37,48,null,null,1,null,5,1,27,{"$nulls":6},1,null,5,0,{"$nulls":8},1]
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[18,2,8,34,{"$nulls":5},1,null,18,1,39,{"$nulls":6},1,null,18,3,4,24,35,{"$nulls":4},1]
[19,5,14,25,30,33,37,null,null,1,null,19,3,46,55,64,null,null,1,{"$nulls":3},19,1,8,{"$nulls":6},1]
[20,5,16,23,30,34,45,1,{"$nulls":3},20,4,3,22,54,64,null,1,{"$nulls":3},20,0,{"$nulls":8},1]
[21,0,{"$nulls":8},1,21,2,25,42,{"$nulls":5},1,null,21,1,65,{"$nulls":6},1]
[22,5,14,30,33,46,55,1,{"$nulls":3},22,0,{"$nulls":8},1,22,5,15,24,26,42,46,1]
[23,4,24,39,43,56,{"$nulls":3},1,null,23,4,13,27,29,53,null,1,{"$nulls":3},23,1,7,{"$nulls":6},1]
[24,2,19,60,{"$nulls":5},1,null,24,2,61,64,{"$nulls":5},1,null,24,0,{"$nulls":8},1]
[25,0,{"$nulls":8},1,25,3,6,7,31,{"$nulls":4},1,null,25,1,14,{"$nulls":6},1]
[26,0,{"$nulls":8},1,26,1,12,{"$nulls":6},1,null,26,5,12,18,25,28,44,1]
[27,1,14,{"$nulls":6},1,null,27,2,9,16,{"$nulls":5},1,null,27,1,23,{"$nulls":4},1]
[28,4,29,36,49,52,{"$nulls":3},1,null,28,5,23,32,40,55,56,1,{"$nulls":3},28,5,5,10,28,31,36,null,null,1]
[29,2,10,33,{"$nulls":5},1,null,29,1,21,{"$nulls":6},1,null,29,4,20,36,55,62,{"$nulls":3},1]
[30,0,{"$nulls":8},1,30,0,{"$nulls":8},1,30,3,29,30,58,{"$nulls":4},1]
[31,5,7,28,33,52,63,null,null,1,null,31,5,1,10,24,61,64,null,null,1,null,31,5,3,4,27,45,46,1]
[32,1,{"$nulls":8},1,32,4,6,15,20,44,{"$nulls":3},1,null,32,4,3,17,38,61,null,1]
[33,3,6,41,63,{"$nulls":4},1,null,33,1,13,{"$nulls":4},1,{"$nulls":3},33,0,{"$nulls":8},1]
[34,1,54,{"$nulls":6},1,null,34,4,12,50,60,62,{"$nulls":3},1,null,34,4,12,19,23,31,null,1]
[35,3,5,40,51,{"$nulls":4},1,null,35,4,8,11,27,57,{"$nulls":3},1,null,35,2,9,56,{"$nulls":5},1]
[36,1,7,{"$nulls":6},1,null,36,5,14,33,38,40,53,null,null,1,null,36,1,61,{"$nulls":6},1]
[37,0,{"$nulls":8},1,37,2,1,21,{"$nulls":5},1,null,37,4,1,33,50,53,{"$nulls":3},1]
[38,4,7,42,46,63,null,1,{"$nulls":3},38,1,51,{"$nulls":6},1,null,38,5,13,33,56,61,62,1]
[39,4,13,17,42,57,null,1,{"$nulls":3},39,4,20,22,37,65,{"$nulls":3},1,null,39,2,13,28,{"$nulls":3},1]
[40,2,10,16,{"$nulls":5},1,null,40,5,30,44,46,48,62,1,{"$nulls":3},40,0,{"$nulls":8},1]
[41,3,19,21,40,{"$nulls":4},1,null,41,4,20,32,39,42,{"$nulls":3},1,null,41,4,6,19,24,50,{"$nulls":3},1]
[42,1,57,{"$nulls":6},1,null,42,4,22,24,48,56,{"$nulls":3},1,null,42,3,1,39,60,{"$nulls":4},1]
[43,1,6,{"$nulls":6},1,null,43,1,28,{"$nulls":6},1,null,43,2,29,47,{"$nulls":5},1]
[44,3,36,54,63,{"$nulls":4},1,null,44,1,19,{"$nulls":6},1,null,44,3,16,17,49,{"$nulls":4},1]
[45,4,7,35,38,41,{"$nulls":3},1,null,45,2,17,57,{"$nulls":5},1,null,45,4,19,22,44,62,{"$nulls":3},1]
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{"sheet":"Sheet2","index":1,"n_rows":29,"n_cols":14,"rows_kept":29,"flags":["formulas_cached_only"]}
["Section 2: Stepwise meta-analysis"]
["TP = True positive; FP = False positive; FN = False negative; TN = True negative; NLR/-LR = Negative likelihood ratio; LCL = Lower confidence level; UCL = Upper confidence level Var = Variability; n = Number of pooled runs; CI = Confidence interval"]
[]
["Run","TP","FP","FN","TN",null,null,"n","Pooled","Pooled",null,"Pooled","Pooled",{"v":0.95,"d":"95%"}]
[1,8,0,27,10,null,null,1,"Runs","NLR","Var","LCL","UCL","CI-width"]
[2,6,0,33,6,null,null,2,"1+2",0.844,0,0.716,0.996,0.28]
[3,8,0,27,10,null,null,3,"1to3",0.828,-0.016,0.725,0.946,0.221]
[4,6,0,32,7,null,null,4,"1to4",0.843,0.015,0.752,0.946,0.194]
[5,4,0,34,7,null,null,5,"1to5",0.865,0.022,0.782,0.957,0.175]
[6,5,0,32,8,null,null,6,"1to6",0.873,0.008,0.797,0.956,0.159]
[7,9,0,26,10,null,null,7,"1to7",0.859,-0.014,0.789,0.935,0.146]
[8,10,0,27,8,null,null,8,"1to8",0.849,-0.01,0.784,0.92,0.136]
[9,8,0,31,6,null,null,9,"1to9",0.849,0,0.786,0.917,0.131]
[10,6,0,30,9,null,null,10,"1to10",0.851,0.002,0.792,0.915,0.123]
[11,6,0,29,10,null,null,11,"1to11",0.852,0.001,0.796,0.912,0.116]
[12,8,0,31,6,null,null,12,"1to12",0.852,0,0.798,0.909,0.111]
[13,13,0,23,9,null,null,13,"1to13",0.841,-0.011,0.789,0.897,0.108]
[14,8,0,29,8,null,null,14,"1to14",0.84,-0.001,0.79,0.893,0.103]
[15,12,0,28,5,null,null,15,"1to15",0.837,-0.003,0.788,0.889,0.101]
[16,10,0,30,5,null,null,16,"1to16",0.836,-0.001,0.788,0.887,0.099]
[17,10,0,30,5,null,null,17,"1to17",0.835,-0.001,0.788,0.885,0.097]
[18,6,0,33,6,null,null,18,"1to18",0.838,0.003,0.792,0.887,0.095]
[19,7,0,28,10,null,null,19,"1to19",0.838,0,0.793,0.885,0.092]
[20,7,0,31,7,null,null,20,"1to20",0.839,0.001,0.796,0.885,0.089]
[21,9,0,26,10,null,null,21,"1to21",0.836,-0.003,0.793,0.88,0.087]
[22,4,0,31,10,null,null,22,"1to22",0.842,0.006,0.801,0.885,0.084]
[23,5,0,31,9,null,null,23,"1to23",0.845,0.003,0.805,0.887,0.082]
[24,8,0,31,6,null,null,24,"1to24",0.845,0,0.806,0.886,0.08]
[25,10,0,26,9,null,null,25,"1to25",0.841,-0.004,0.803,0.882,0.079]