{"text_format":"3","workbook":"xlsx","n_sheets":6,"sheets":["Legend","Haplotypes by patient","Allele 1 field ","1 field haplo","Allele 2 field","2 field haplo"],"read":"whole","date_system":"1900"}

{"sheet":"Legend","index":0,"n_rows":3,"n_cols":1,"rows_kept":3}
["Supplemental Table 4. HLA class II genotyping (1 and 2 field) and comparison to the in-house control cohort (n=873 controls)"]
["Statistical analysis is provided under 3 different models (ADD, additive; DOM, dominant; REC, recessive)  "]
["AF : allele frequency"]

{"sheet":"Haplotypes by patient","index":1,"n_rows":48,"n_cols":10,"rows_kept":48}
["1 field"]
["Patient ","DRB1_1","DQA1_1","DQB1_1","DRB1_2","DQA1_2","DQB1_2","h1","h2","Phase certainty"]
[1,"DRB1*07","DQA1*02","DQB1*02","DRB1*07","DQA1*02","DQB1*02","DRB1*07_DQA1*02_DQB1*02","DRB1*07_DQA1*02_DQB1*02",1]
[2,"DRB1*01","DQA1*01","DQB1*05","DRB1*13","DQA1*01","DQB1*06","DRB1*01_DQA1*01_DQB1*05","DRB1*13_DQA1*01_DQB1*06",1]
[3,"DRB1*01","DQA1*01","DQB1*05","DRB1*04","DQA1*03","DQB1*03","DRB1*01_DQA1*01_DQB1*05","DRB1*04_DQA1*03_DQB1*03",1]
[4,"DRB1*13","DQA1*01","DQB1*06","DRB1*15","DQA1*01","DQB1*06","DRB1*13_DQA1*01_DQB1*06","DRB1*15_DQA1*01_DQB1*06",1]
[5,"DRB1*01","DQA1*01","DQB1*05","DRB1*04","DQA1*03","DQB1*03","DRB1*01_DQA1*01_DQB1*05","DRB1*04_DQA1*03_DQB1*03",1]
[6,"DRB1*03","DQA1*05","DQB1*02","DRB1*13","DQA1*01","DQB1*06","DRB1*03_DQA1*05_DQB1*02","DRB1*13_DQA1*01_DQB1*06",1]
[7,"DRB1*07","DQA1*02","DQB1*02","DRB1*13","DQA1*01","DQB1*06","DRB1*07_DQA1*02_DQB1*02","DRB1*13_DQA1*01_DQB1*06",1]
[8,"DRB1*03","DQA1*05","DQB1*02","DRB1*13","DQA1*01","DQB1*06","DRB1*03_DQA1*05_DQB1*02","DRB1*13_DQA1*01_DQB1*06",1]
[9,"DRB1*04","DQA1*03","DQB1*03","DRB1*13","DQA1*05","DQB1*03","DRB1*04_DQA1*03_DQB1*03","DRB1*13_DQA1*05_DQB1*03",0.999]
[10,"DRB1*04","DQA1*03","DQB1*03","DRB1*16","DQA1*01","DQB1*05","DRB1*04_DQA1*03_DQB1*03","DRB1*16_DQA1*01_DQB1*05",1]
[11,"DRB1*01","DQA1*01","DQB1*05","DRB1*04","DQA1*03","DQB1*03","DRB1*01_DQA1*01_DQB1*05","DRB1*04_DQA1*03_DQB1*03",1]
[12,"DRB1*04","DQA1*03","DQB1*03","DRB1*09","DQA1*03","DQB1*03","DRB1*04_DQA1*03_DQB1*03","DRB1*09_DQA1*03_DQB1*03",1]
[13,"DRB1*08","DQA1*04","DQB1*04","DRB1*08","DQA1*04","DQB1*04","DRB1*08_DQA1*04_DQB1*04","DRB1*08_DQA1*04_DQB1*04",1]
[14,"DRB1*07","DQA1*01","DQB1*02","DRB1*07","DQA1*02","DQB1*02","DRB1*07_DQA1*01_DQB1*02","DRB1*07_DQA1*02_DQB1*02",1]
[15,"DRB1*11","DQA1*05","DQB1*03","DRB1*11","DQA1*05","DQB1*03","DRB1*11_DQA1*05_DQB1*03","DRB1*11_DQA1*05_DQB1*03",1]
[16,"DRB1*11","DQA1*05","DQB1*03","DRB1*11","DQA1*05","DQB1*03","DRB1*11_DQA1*05_DQB1*03","DRB1*11_DQA1*05_DQB1*03",1]
[17,"DRB1*11","DQA1*05","DQB1*03","DRB1*13","DQA1*01","DQB1*06","DRB1*11_DQA1*05_DQB1*03","DRB1*13_DQA1*01_DQB1*06",0.998]
[18,"DRB1*03","DQA1*05","DQB1*02","DRB1*15","DQA1*01","DQB1*06","DRB1*03_DQA1*05_DQB1*02","DRB1*15_DQA1*01_DQB1*06",1]
[19,"DRB1*04","DQA1*03","DQB1*03","DRB1*13","DQA1*01","DQB1*06","DRB1*04_DQA1*03_DQB1*03","DRB1*13_DQA1*01_DQB1*06",1]
[20,"DRB1*04","DQA1*03","DQB1*02","DRB1*07","DQA1*02","DQB1*03","NA","NA",0.011]
[21,"DRB1*10","DQA1*01","DQB1*05","DRB1*13","DQA1*01","DQB1*06","DRB1*10_DQA1*01_DQB1*05","DRB1*13_DQA1*01_DQB1*06",1]
[]
[]
["2 field"]
["Patient","DRB1_1","DQA1_1","DQB1_1","DRB1_2","DQA1_2","DQB1_2","h1","h2","Phase certainty"]
[1,"DRB1*07:01","DQA1*02:01","DQB1*02:01","DRB1*07:01","DQA1*02:01","DQB1*02:01","DRB1*07:01_DQA1*02:01_DQB1*02:01","DRB1*07:01_DQA1*02:01_DQB1*02:01",1]
[2,"DRB1*01:01","DQA1*01:01","DQB1*05:01","DRB1*13:02","DQA1*01:02","DQB1*06:04","DRB1*03:01_DQA1*03:01_DQB1*02:01","DRB1*13:02_DQA1*01:02_DQB1*06:04",1]
[3,"DRB1*01:01","DQA1*01:01","DQB1*05:01","DRB1*04:02","DQA1*03:01","DQB1*03:02","DRB1*11:12_DQA1*05:01_DQB1*03:01","DRB1*04:02_DQA1*03:01_DQB1*03:02",1]
[4,"DRB1*13:02","DQA1*01:02","DQB1*06:04","DRB1*15:01","DQA1*01:02","DQB1*06:02","DRB1*13:01_DQA1*01:02_DQB1*05:01","DRB1*15:01_DQA1*01:02_DQB1*06:02",1]
[5,"DRB1*01:01","DQA1*01:01","DQB1*05:01","DRB1*04:02","DQA1*03:01","DQB1*03:02","DRB1*03:01_DQA1*01:02_DQB1*02:01","DRB1*04:02_DQA1*03:01_DQB1*03:02",1]
[6,"DRB1*03:01","DQA1*05:01","DQB1*02:01","DRB1*13:02","DQA1*01:02","DQB1*06:04","DRB1*01:02_DQA1*01:01_DQB1*06:02","DRB1*13:02_DQA1*01:02_DQB1*06:04",1]
[7,"DRB1*07:01","DQA1*02:01","DQB1*02:01","DRB1*13:01","DQA1*01:03","DQB1*06:03","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*13:01_DQA1*01:03_DQB1*06:03",1]
[8,"DRB1*03:01","DQA1*05:01","DQB1*02:01","DRB1*13:02","DQA1*01:02","DQB1*06:04","DRB1*04:01_DQA1*01:01_DQB1*03:02","DRB1*13:02_DQA1*01:02_DQB1*06:04",1]
[9,"DRB1*04:05","DQA1*03:01","DQB1*03:02","DRB1*13:03","DQA1*05:01","DQB1*03:01","DRB1*07:01_DQA1*03:01_DQB1*03:01","DRB1*13:03_DQA1*05:01_DQB1*03:01",1]
[10,"DRB1*04:03","DQA1*03:01","DQB1*03:02","DRB1*16:02","DQA1*01:02","DQB1*05:02","DRB1*04:01_DQA1*03:01_DQB1*03:01","DRB1*16:02_DQA1*01:02_DQB1*05:02",1]
[11,"DRB1*01:01","DQA1*01:01","DQB1*05:01","DRB1*04:07","DQA1*03:01","DQB1*03:01","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*04:07_DQA1*03:01_DQB1*03:01",1]
[12,"DRB1*04:03","DQA1*03:01","DQB1*03:02","DRB1*09:01","DQA1*03:01","DQB1*03:03","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*09:01_DQA1*03:01_DQB1*03:03",0.999]
[13,"DRB1*08:01","DQA1*04:01","DQB1*04:02","DRB1*08:01","DQA1*04:01","DQB1*04:02","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*08:01_DQA1*04:01_DQB1*04:02",1]
[14,"DRB1*07:01","DQA1*01:03","DQB1*02:01","DRB1*07:01","DQA1*02:01","DQB1*02:01","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*07:01_DQA1*02:01_DQB1*02:01",1]
[15,"DRB1*11:01","DQA1*05:01","DQB1*03:01","DRB1*11:01","DQA1*05:01","DQB1*03:01","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*11:01_DQA1*05:01_DQB1*03:01",1]
[16,"DRB1*11:01","DQA1*05:01","DQB1*03:01","DRB1*11:01","DQA1*05:01","DQB1*03:01","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*11:01_DQA1*05:01_DQB1*03:01",1]
[17,"DRB1*11:01","DQA1*05:01","DQB1*03:01","DRB1*13:01","DQA1*01:03","DQB1*06:03","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*13:01_DQA1*01:03_DQB1*06:03",1]
[18,"DRB1*03:01","DQA1*05:01","DQB1*02:01","DRB1*15:01","DQA1*01:02","DQB1*06:02","DRB1*04:01_DQA1*03:01_DQB1*03:02","DRB1*15:01_DQA1*01:02_DQB1*06:02",1]
[19,"DRB1*04:01","DQA1*03:01","DQB1*03:01","DRB1*13:01","DQA1*01:03","DQB1*06:03","DRB1*13:01_DQA1*01:02_DQB1*03:03","DRB1*13:01_DQA1*01:03_DQB1*06:03",1]
[20,"DRB1*04:01","DQA1*03:01","DQB1*03:02","DRB1*07:01","DQA1*02:01","DQB1*02:01","DRB1*03:01_DQA1*05:01_DQB1*02:01","DRB1*07:01_DQA1*02:01_DQB1*02:01",1]
[21,"DRB1*10:01","DQA1*01:01","DQB1*05:01","DRB1*13:02","DQA1*01:02","DQB1*06:04","DRB1*04:05_DQA1*03:01_DQB1*03:02","DRB1*13:02_DQA1*01:02_DQB1*06:04",1]

{"sheet":"Allele 1 field ","index":2,"n_rows":23,"n_cols":10,"rows_kept":23}
["ALLELE","HARDY WEINBERG EQUILIBRIUM (p)","AF IN PATIENTS","AF IN CONTROLS","ADD OR [95% CI]","P-Value ADD","DOM OR [95% CI]","P-Value DOM","REC OR [95 CI]","P-Value REC"]
["DQA1_DQA1*01",0.02344,0.40476190476190477,0.4209621993127148,"0,891051 [0,37709;2,10552]",0.792613,"0,991682 [0,284008;3,4627]",0.989554,"0,334646 [0,0161117;6,95074]",0.479396]
["DQB1_DQB1*03",0.7018,0.35714285714285715,0.34421534936998854,"0,955548 [0,454222;2,01019]",0.904615,"0,686919 [0,117071;4,03052]",0.677427,"0,344372 [0,0000809857;1464,36]",0.802533]
["DQB1_DQB1*06",0.9272,0.23809523809523808,0.2411225658648339,"0,885467 [0,367486;2,13356]",0.786317,"1,00713 [0,349929;2,8986]",0.989496,"0,469373 [0,0546778;4,02925]",0.490493]
["DRB1_DRB1*13",0.215,0.21428571428571427,0.13974799541809851,"1,8278 [0,637895;5,23728]",0.261477,"1,97248 [0,662411;5,87351]",0.222406,"0,357712 [0,000687978;185,991]",0.747308]
["DQA1_DQA1*03",0.5394,0.21428571428571427,0.13688430698739978,"1,82502 [0,656925;5,07014]",0.248513,"1,55736 [0,390391;6,21264]",0.530314,"0,357162 [0,000245498;519,615]",0.781715]
["DQB1_DQB1*02",0.1404,0.21428571428571427,0.20847651775486828,"1,14944 [0,382394;3,45512]",0.80411,"1,89568 [0,523168;6,86894]",0.330214,"0,350875 [0,000102586;1200,1]",0.800844]
["DQA1_DQA1*05",0.3046,0.21428571428571427,0.26804123711340205,"0,671094 [0,268504;1,67732]",0.393453,"0,540553 [0,168915;1,72985]",0.299952,"0,919103 [0,121792;6,93603]",0.934801]
["DRB1_DRB1*04",1,0.19047619047619047,0.13287514318442153,"1,61619 [0,553445;4,71966]",0.379942,"0,330281 [0,0237522;4,59265]",0.409447,"0,361601 [0,00000000526569;24831600]",0.912024]
["DRB1_DRB1*07",1,0.14285714285714285,0.1420389461626575,"0,926916 [0,291254;2,94992]",0.897763,"1,03993 [0,0770125;14,0426]",0.976481,"7,8434 [0,483749;127,171]",0.147321]
["DQB1_DQB1*05",1,0.14285714285714285,0.17583046964490265,"0,893844 [0,323557;2,46929]",0.828631,"0,35805 [0,0000732268;1750,72]",0.812678,"0,334313 [0,0168947;6,61538]",0.471889]
["DRB3_DRB3*03",1,0.14285714285714285,0.06758304696449026,"1,53096 [0,566118;4,14018]",0.401435,"0,35994 [0,0000000527404;2456490]",0.898727,"2,17345 [0,23797;19,8507]",0.491526]
["DQA1_DQA1*02",0.6493,0.11904761904761904,0.1420389461626575,"0,76469 [0,22179;2,63651]",0.670962,"0,881326 [0,286812;2,70817]",0.825437,"0,530883 [0,0530459;5,31308]",0.590021]
["DRB1_DRB1*11",0.1579,0.11904761904761904,0.13802978235967928,"0,777321 [0,292791;2,06368]",0.613098,"0,572829 [0,162786;2,01574]",0.385414,"1,73198 [0,141905;21,1393]",0.66698]
["DRB1_DRB1*01",0.3725,0.09523809523809523,0.11053837342497136,"0,817448 [0,260296;2,56716]",0.729924,"1,03686 [0,257731;4,17129]",0.959357,"0,332712 [0,00418957;26,4221]",0.621983]
["DRB1_DRB1*03",1,0.07142857142857142,0.1036655211912944,"0,682547 [0,125094;3,72416]",0.659092,"0,352666 [0,00141887;87,6565]",0.711119,"0,356224 [0,00000417074;30425,2]",0.858596]
["DQA1_DQA1*04",0.1891,0.047619047619047616,0.029782359679266894,"2,1157 [0,359119;12,4643]",0.407568,"1,16945 [0,124105;11,0199]",0.891209,"76,9731 [0,823159;7197,7]",0.101017]
["DRB1_DRB1*08",1,0.047619047619047616,0.03150057273768614,"2,04293 [0,351824;11,8626]",0.426034,"0,325866 [0,00331519;32,031]",0.631938,"12,2958 [0,120444;1255,25]",0.10873]
["DRB1_DRB1*15",1,0.047619047619047616,0.12142038946162657,"0,414251 [0,137034;1,25227]",0.118431,"0,357367 [0,000000773097;165194]",0.877124,"0,265231 [0,0150725;4,66727]",0.36438]
["DQB1_DQB1*04",1,0.047619047619047616,0.030355097365406643,"2,06651 [0,35401;12,0632]",0.420032,"0,361769 [0,0000316567;4134,25]",0.831113,"0,364748 [0,0000000827412;1607920]",0.897195]
["DRB1_DRB1*10",0.0739,0.023809523809523808,0.009163802978235968,"6,90781 [0,221813;215,127]",0.270636,"7,70897 [0,22807;260,57]",0.255514,"0,365552 [0,000000000000440396;303428000000]",0.942707]
["DRB1_DRB1*16",1,0.023809523809523808,0.019473081328751432,"1,77535 [0,12485;25,2451]",0.671718,"0,361717 [0,000000000777472;168288000]",0.920453,"NA [NA;NA]","NA"]
["DRB1_DRB1*09",1,0.023809523809523808,0.006872852233676976,"5,45676 [0,200646;148,402]",0.313995,"0,363274 [0,00000000000415995;31723400000]",0.937209,"NA [NA;NA]","NA"]

{"sheet":"1 field haplo","index":3,"n_rows":14,"n_cols":10,"rows_kept":14}
["HAPLOTYPE","HARDY WEINBERG EQUILIBRIUM (p)","FREQUENCY IN PATIENTS","FREQUENCY IN CONTROLS","ADD OR [95% CI]","P-Value ADD","DOM OR [95% CI]","P-Value DOM","REC OR [95 CI]","P-Value REC"]
["DRB1*07_DQA1*02_DQB1*02",0.2225,0.1,0.0927710843373494,"1,22369[0,281967;5,31063]",0.787503,"0,788238[0,160045;3,88216]",0.769886,"59,4551[0,557151;6344,61]",0.0864396]
["DRB1*08_DQA1*04_DQB1*04",0.5527,0.05,0.030120481927710843,"2,12073[0,356008;12,6331]",0.409003,"1,15437[0,12136;10,9804]",0.900593,"12,2901[0,120425;1254,29]",0.10881]
["DRB1*15_DQA1*01_DQB1*06",0.5051,0.05,0.11686746987951807,"0,422721[0,136539;1,30873]",0.13535,"0,37252[0,0934122;1,48558]",0.161769,"0,263119[0,0143952;4,80938]",0.36781]
["DRB1*13_DQA1*01_DQB1*06",1,0.2,0.11987951807228915,"2,1228[0,689544;6,53514]",0.189507,"2,33821[0,725952;7,53109]",0.154651,"0,345692[0,000546004;218,868]",0.746893]
["DRB1*10_DQA1*01_DQB1*05",0.07761,0.025,0.00963855421686747,"6,82353[0,218809;212,791]",0.27388,"7,61784[0,22504;257,873]",0.258492,"0,347235[0,00000000000041977;287234000000]",0.939778]
["DRB1*04_DQA1*03_DQB1*03",1,0.175,0.11325301204819277,"1,72368[0,550356;5,39848]",0.349931,"1,92866[0,578002;6,43551]",0.285367,"0,347266[0,00138037;87,3634]",0.70765]
["DRB1*09_DQA1*03_DQB1*03",1,0.025,0.007228915662650603,"5,42332[0,198719;148,01]",0.316265,"5,42332[0,198719;148,01]",0.316265,"NA[NA;NA]","NA"]
["DRB1*07_DQA1*01_DQB1*02",1,0.025,0,"7,1459[0,12025;424,646]",0.345373,"7,1459[0,12025;424,646]",0.345373,"NA[NA;NA]","NA"]
["DRB1*11_DQA1*05_DQB1*03",0.2064,0.125,0.14337349397590363,"0,765879[0,286167;2,04975]",0.59539,"0,556773[0,15592;1,98817]",0.367194,"1,71686[0,140446;20,9874]",0.672179]
["DRB1*01_DQA1*01_DQB1*05",0.1254,0.1,0.11506024096385542,"0,805242[0,25482;2,5446]",0.712137,"0,867662[0,228114;3,30026]",0.835027,"0,331992[0,00888095;12,4107]",0.55064]
["DRB1*03_DQA1*05_DQB1*02",0.4642,0.075,0.10481927710843374,"0,680168[0,125303;3,69209]",0.655195,"0,740567[0,115001;4,76899]",0.751957,"0,322637[0,00252751;41,1846]",0.647517]
["DRB1*16_DQA1*01_DQB1*05",1,0.025,0.019879518072289156,"1,78134[0,122802;25,8398]",0.672217,"1,78134[0,122802;25,8398]",0.672217,"NA[NA;NA]","NA"]
["DRB1*13_DQA1*05_DQB1*03",1,0.025,0.014457831325301205,"1,27206[0,0670757;24,124]",0.872659,"1,27206[0,0670757;24,124]",0.872659,"NA[NA;NA]","NA"]

{"sheet":"Allele 2 field","index":4,"n_rows":36,"n_cols":10,"rows_kept":36}
["ALLELE","HARDY WEINBERG EQUILIBRIUM (p)","AF IN PATIENTS","AF IN CONTROLS","ADD OR [95% CI]","P-Value ADD","DOM OR [95% CI]","P-Value DOM","REC OR [95 CI]","P-Value REC"]
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{"sheet":"2 field haplo","index":5,"n_rows":20,"n_cols":10,"rows_kept":20}
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