Table-S5: KEGG analysis results 								
ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
hsa04110	Cell cycle	34/421	127/8191	4.37E-16	1.34E-13	1.10E-13	SFN/CCNB1/CDC25B/PKMYT1/MCM3/ESPL1/CHEK1/CDKN2A/BUB1/CDC7/CDC6/CDC20/E2F3/CCNA2/BUB1B/MCM7/TTK/DBF4/E2F1/CDC45/PTTG1/MAD2L1/CDK1/RBL1/MCM6/CCNB2/PLK1/MCM4/MCM5/CDC25A/ORC1/CDC25C/CDKN2C/MCM2	34
hsa03030	DNA replication	11/421	36/8191	1.09E-06	0.000166646	0.000136563	RNASEH2A/POLA1/MCM3/RFC4/MCM7/POLD1/FEN1/MCM6/MCM4/MCM5/MCM2	11
hsa04145	Phagosome	23/421	152/8191	2.67E-06	0.000272981	0.000223701	TUBB6/ITGAV/MSR1/TUBA1C/FCGR3A/FCGR2A/ITGB2/HLA-DMB/TLR2/TAP1/TUBB2B/HLA-DQA2/MRC2/HLA-DOA/CD209/ITGAM/CYBB/TUBA1B/TUBA3C/ITGA2/NCF2/HLA-DOB/COMP	23
hsa00010	Glycolysis / Gluconeogenesis	14/421	67/8191	5.79E-06	0.000444258	0.000364058	HK2/ENO2/PCK1/PKM/PFKP/HKDC1/ALDOA/ADH1B/FBP1/ACSS1/ENO1/ALDH3A1/ALDH3B1/HK3	14
hsa00051	Fructose and mannose metabolism	9/421	33/8191	2.94E-05	0.001804132	0.001478442	HK2/AKR1B1/AKR1B10/PFKP/HKDC1/ALDOA/FBP1/PFKFB3/HK3	9
hsa05323	Rheumatoid arthritis	15/421	93/8191	7.00E-05	0.003579799	0.002933557	CCL20/MMP1/ITGB2/HLA-DMB/CXCL8/TLR2/CXCL6/CD86/CSF1/HLA-DQA2/HLA-DOA/CXCL1/CXCL5/IL18/HLA-DOB	15
hsa05140	Leishmaniasis	13/421	77/8191	0.00013129	0.005128231	0.004202459	FCGR3A/FCGR2A/ITGB2/HLA-DMB/TLR2/HLA-DQA2/HLA-DOA/ITGAM/CYBB/MAPK13/NCF2/HLA-DOB/MARCKSL1	13
hsa04512	ECM-receptor interaction	14/421	88/8191	0.000141462	0.005128231	0.004202459	COL9A2/ITGAV/ITGA3/SPP1/NPNT/HMMR/ITGB4/RELN/TNC/CD44/ITGA2/LAMC2/COMP/COL4A5	14
hsa00980	Metabolism of xenobiotics by cytochrome P450	13/421	78/8191	0.000150339	0.005128231	0.004202459	CYP3A4/CYP2C9/CYP2A7/GSTP1/CYP2B6/ADH1B/CYP2A6/CYP2S1/CYP1A2/CYP2E1/ALDH3A1/CYP2A13/ALDH3B1	13
hsa00982	Drug metabolism - cytochrome P450	12/421	72/8191	0.000268639	0.008247211	0.006758386	CYP3A4/CYP2C9/CYP2A7/GSTP1/CYP2B6/ADH1B/CYP2A6/CYP2C8/CYP1A2/CYP2E1/ALDH3A1/ALDH3B1	12
hsa04976	Bile secretion	13/421	89/8191	0.000573172	0.015996715	0.013108914	AQP8/CYP3A4/SLC2A1/SCTR/SLC27A5/NCEH1/SLC22A1/SLCO1B3/ABCC4/FXYD2/ATP1B3/CFTR/SLC10A1	13
hsa00591	Linoleic acid metabolism	7/421	30/8191	0.000654474	0.016011173	0.013120762	CYP3A4/CYP2C9/PLAAT2/CYP2C8/CYP1A2/CYP2E1/PLA2G2D	7
hsa04914	Progesterone-mediated oocyte maturation	14/421	102/8191	0.000677998	0.016011173	0.013120762	CCNB1/AURKA/CDC25B/PKMYT1/BUB1/SPDYC/CCNA2/MAD2L1/CDK1/CCNB2/PLK1/CDC25A/MAPK13/CDC25C	14
hsa05230	Central carbon metabolism in cancer	11/421	70/8191	0.000805236	0.017657676	0.014470031	HK2/G6PD/PKM/SLC2A1/PFKP/SLC1A5/GLS2/HKDC1/SLC16A3/FGFR1/HK3	11
hsa00360	Phenylalanine metabolism	5/421	16/8191	0.000954399	0.019533357	0.016007106	IL4I1/ALDH3A1/HPD/ALDH3B1/TAT	5
hsa04114	Oocyte meiosis	16/421	131/8191	0.001061774	0.020372791	0.016695001	CCNB1/AURKA/PKMYT1/ESPL1/BUB1/CDC20/SPDYC/PTTG1/MAD2L1/CDK1/CCNB2/FBXO5/PLK1/MAPK13/CDC25C/ITPR3	16
hsa05150	Staphylococcus aureus infection	13/421	96/8191	0.001187178	0.021439043	0.017568768	KRT20/FCGR3A/FCGR2A/ITGB2/HLA-DMB/KRT19/HLA-DQA2/HLA-DOA/ITGAM/KRT17/PTAFR/KRT23/HLA-DOB	13
hsa04610	Complement and coagulation cascades	12/421	86/8191	0.001395112	0.023794416	0.019498939	C6/ITGAX/CFHR3/SERPINE2/ITGB2/C7/F9/ITGAM/PLAU/PLAUR/VSIG4/CFHR4	12
hsa04640	Hematopoietic cell lineage	13/421	99/8191	0.00158231	0.025566791	0.020951356	ITGA3/HLA-DMB/KITLG/CSF1/CD24/HLA-DQA2/CD7/HLA-DOA/ITGAM/CD44/EPO/ITGA2/HLA-DOB	13
hsa05152	Tuberculosis	19/421	180/8191	0.002197798	0.030790078	0.025231712	ITGAX/FCGR3A/FCER1G/FCGR2A/ITGB2/HLA-DMB/TLR2/RIPK2/SPHK1/HLA-DQA2/SRC/MRC2/HLA-DOA/SYK/CD209/ITGAM/MAPK13/IL18/HLA-DOB	19
hsa01200	Carbon metabolism	14/421	115/8191	0.002210407	0.030790078	0.025231712	HK2/G6PD/ENO2/PKM/PFKP/HKDC1/ME1/ALDOA/SDS/FBP1/ACSS1/ENO1/TKT/HK3	14
hsa05166	Human T-cell leukemia virus 1 infection	22/421	222/8191	0.002296754	0.030790078	0.025231712	SPI1/SLC2A1/IL2RG/ESPL1/CHEK1/CDKN2A/CDC20/E2F3/CCNA2/ITGB2/BUB1B/HLA-DMB/E2F1/PTTG1/HLA-DQA2/MAD2L1/HLA-DOA/CCNB2/CDKN2C/MMP7/HLA-DOB/CREB3L1	22
hsa00830	Retinol metabolism	10/421	68/8191	0.002306749	0.030790078	0.025231712	RDH16/CYP3A4/CYP2C9/CYP2A7/CYP2B6/ADH1B/CYP2A6/CYP2S1/CYP2C8/CYP1A2	10
hsa04218	Cellular senescence	17/421	156/8191	0.002637949	0.033743763	0.027652184	CCNB1/CHEK1/LIN9/MYBL2/CDKN2A/E2F3/CCNA2/CXCL8/E2F1/CDK1/RBL1/CCNB2/FOXM1/CDC25A/MAPK13/ITPR3/SQSTM1	17
hsa00565	Ether lipid metabolism	8/421	50/8191	0.003649344	0.044376212	0.036365214	PLA2G7/PLPP2/LPCAT1/PLAAT2/LPCAT4/PLA2G2D/PAFAH1B3/GAL3ST1	8
hsa04066	HIF-1 signaling pathway	13/421	109/8191	0.003758246	0.044376212	0.036365214	HK2/ENO2/SLC2A1/PFKP/HKDC1/ALDOA/PFKFB3/CYBB/HMOX1/ENO1/EPO/EGLN3/HK3	13
hsa00052	Galactose metabolism	6/421	31/8191	0.004374495	0.047192331	0.038672954	HK2/AKR1B1/AKR1B10/PFKP/HKDC1/HK3	6
hsa05219	Bladder cancer	7/421	41/8191	0.004437763	0.047192331	0.038672954	CDKN2A/MMP1/E2F3/CXCL8/MMP9/E2F1/SRC	7
hsa00340	Histidine metabolism	5/421	22/8191	0.004457907	0.047192331	0.038672954	ALDH3A1/FTCD/CNDP1/ALDH3B1/UROC1	5
hsa01230	Biosynthesis of amino acids	10/421	75/8191	0.004778936	0.048904447	0.040075991	ENO2/PKM/PFKP/PYCR1/ALDOA/ASNS/SDS/CTH/ENO1/TKT	10
hsa03460	Fanconi anemia pathway	8/421	54/8191	0.005914582	0.058573444	0.047999497	FANCI/FANCG/UBE2T/FANCE/FAAP24/RAD51/FANCD2/RMI2	8